id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257754-pqxkyg8z	Reggiori, Fulvio	Membrane Origin for Autophagy	2006-07-21		.txt	text/plain	9205	481	46	In addition, a study analyzing conditional knock-out mice defective for autophagy has revealed that the mutant animal accumulates numerous ubiquitinated aggregates in the cytosol, suggesting that this covalent protein modification could serve to specifically target to autophagosomes large structures that have to be eliminated (Komatsu et al., 2005) . In contrast to mammalian cells where several isolation membranes can be simultaneously activated, a single perivacuolar site of organization for double-membrane vesicle formation (named the pre-autophagosomal structure, PAS) is observed in the yeast S. Because the three mammalian Atg8 homologs are diVerently expressed in various tissues (Tanida et al., 2004) , another intriguing option is that these proteins are involved in supplying the autophagosome with membranes derived from diVerent compartments depending on the cell type; for example, GATE-16 from the Golgi complex and GABARAP from the same organelle as well as the synaptic cisternae (Kittler et al., 2001; Kneussel et al., 2000; Sagiv et al., 2000) .	./cache/cord-257754-pqxkyg8z.txt	./txt/cord-257754-pqxkyg8z.txt