id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-324840-ug5a9wx6	De Pascale, Gennaro	The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock	2013-10-02		.txt	text/plain	5196	220	34	In a cohort of critically ill pediatric patients, Fidler and coworkers observed that MBL levels less than 1000 ng/mL, consistent with MBL-2 gene exon 1 polymorphisms, significantly increased the risk of developing systemic inflammatory response syndrome (SIRS) and progression to severe sepsis/septic shock [32] . The association between the deficiency of this protein and worse outcome during severe systemic infections (i.e., evolution to refractory septic shock) may be also related to the significant interaction between complement activation, inflammatory cytokines' "storm", and coagulation cascade. Hence MBL, due to its pivotal role in the crosstalking among complement activation, coagulation, and systemic inflammation, may represent a key point for the understanding of the development of systemic severe infections, as interestingly investigated in animal models and clinical studies involving patients with severe sepsis/septic shock.	./cache/cord-324840-ug5a9wx6.txt	./txt/cord-324840-ug5a9wx6.txt