id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010994-1ynel55w	Abe, Kyoko	Nicorandil, a K(ATP) Channel Opener, Attenuates Ischemia–Reperfusion Injury in Isolated Rat Lungs	2020-02-21		.txt	text/plain	3600	206	58	Therefore, the objective of the present study was to investigate whether nicorandil reduces the risk of IR injury in an isolated buffer perfused rat lung model, and whether nicorandil's beneficial effects are a result of its K ATP channel opener properties and nitric oxide production, or are attributable to activation of the soluble guanylyl cyclase (sGC)/ cyclic guanosine monophosphate (cGMP) pathway. (1) nicorandil administration before ischemia ameliorated increases in pulmonary microvascular permeability after IR in isolated rat lung preparations; (2) the protective effects of nicorandil against IR lung injury was blocked by glibenclamide as a K ATP channel blocker and ODQ as a sGC inhibitor. [6] , isoflurane-sevoflurane administration before ischemia attenuated IR injury without a significant PVR change in isolated rat lungs which was similar to the results in the present study. These results suggest that the protective effects of nicorandil after IR lung injury can be explained by the activation of a K ATP channel opener as well as that of the sGC-cGMP pathway.	./cache/cord-010994-1ynel55w.txt	./txt/cord-010994-1ynel55w.txt