id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005228-187d3pxz	Wang, Jian	Role of microbiota on lung homeostasis and diseases	2017-10-09		.txt	text/plain	5001	250	39	In humans, lung microbiota have been identified in healthy donors and in patients with chronic pulmonary disease, and the composition of lung microbiota is similar as the microbiota in the upper respiratory tract, but the number is lower, likely resulting from transient entry rather than independent communities with indistinguishable structure (Charlson et al., 2011) . In our previous studies, we found that the microbiota in upper respiratory tract also provided protection against lethal inflammation in the lungs caused by influenza infection in a TLR2-and alveolar macrophagedependent manner. Priming SPF mice with TLR2-ligand + Staphylococcus aureus, which commonly colonizes the upper respiratory tract in human, promoted the differentiation of M2 macrophages with immunosuppressive function, which then significantly reduced influenza-mediated inflammatory response in the lungs (Wang et al., 2013) (Figure 1C ). aureus), a common microbiota in upper respiratory tract and lung, promote the differentiation of M2 alveolar macrophages then provide protection against lethal inflammation in the lungs caused by influenza infection.	./cache/cord-005228-187d3pxz.txt	./txt/cord-005228-187d3pxz.txt