id	sid	tid	token	lemma	pos
cord-283427-fef9qsik	1	1	key	key	JJ
cord-283427-fef9qsik	2	1	:	:	:
cord-283427-fef9qsik	2	2	cord-283427-fef9qsik	cord-283427-fef9qsik	NNP
cord-283427-fef9qsik	2	3	authors	author	NNS
cord-283427-fef9qsik	2	4	:	:	:
cord-283427-fef9qsik	2	5	Kim	Kim	NNP
cord-283427-fef9qsik	2	6	,	,	,
cord-283427-fef9qsik	2	7	Gwang	Gwang	NNP
cord-283427-fef9qsik	2	8	-	-	HYPH
cord-283427-fef9qsik	2	9	Ho	Ho	NNP
cord-283427-fef9qsik	2	10	;	;	:
cord-283427-fef9qsik	2	11	Yi	Yi	NNP
cord-283427-fef9qsik	2	12	,	,	,
cord-283427-fef9qsik	2	13	Sun	Sun	NNP
cord-283427-fef9qsik	2	14	Shin	Shin	NNP
cord-283427-fef9qsik	2	15	title	title	NN
cord-283427-fef9qsik	2	16	:	:	:
cord-283427-fef9qsik	2	17	Verification	verification	NN
cord-283427-fef9qsik	2	18	with	with	IN
cord-283427-fef9qsik	2	19	the	the	DT
cord-283427-fef9qsik	2	20	utility	utility	NN
cord-283427-fef9qsik	2	21	of	of	IN
cord-283427-fef9qsik	2	22	an	an	DT
cord-283427-fef9qsik	2	23	established	establish	VBN
cord-283427-fef9qsik	2	24	rapid	rapid	JJ
cord-283427-fef9qsik	2	25	assessment	assessment	NN
cord-283427-fef9qsik	2	26	of	of	IN
cord-283427-fef9qsik	2	27	brain	brain	NN
cord-283427-fef9qsik	2	28	safety	safety	NN
cord-283427-fef9qsik	2	29	for	for	IN
cord-283427-fef9qsik	2	30	newly	newly	RB
cord-283427-fef9qsik	2	31	developed	develop	VBN
cord-283427-fef9qsik	2	32	vaccines	vaccine	NNS
cord-283427-fef9qsik	2	33	date	date	NN
cord-283427-fef9qsik	2	34	:	:	:
cord-283427-fef9qsik	2	35	2019	2019	CD
cord-283427-fef9qsik	2	36	-	-	HYPH
cord-283427-fef9qsik	2	37	11	11	CD
cord-283427-fef9qsik	2	38	-	-	SYM
cord-283427-fef9qsik	2	39	29	29	CD
cord-283427-fef9qsik	2	40	journal	journal	NN
cord-283427-fef9qsik	2	41	:	:	:
cord-283427-fef9qsik	3	1	Lab	Lab	NNP
cord-283427-fef9qsik	3	2	Anim	anim	NN
cord-283427-fef9qsik	3	3	Res	res	NN
cord-283427-fef9qsik	3	4	DOI	doi	NN
cord-283427-fef9qsik	3	5	:	:	:
cord-283427-fef9qsik	3	6	10.1186	10.1186	CD
cord-283427-fef9qsik	3	7	/	/	SYM
cord-283427-fef9qsik	3	8	s42826	s42826	NNP
cord-283427-fef9qsik	3	9	-	-	HYPH
cord-283427-fef9qsik	3	10	019	019	CD
cord-283427-fef9qsik	3	11	-	-	HYPH
cord-283427-fef9qsik	3	12	0027	0027	CD
cord-283427-fef9qsik	3	13	-	-	SYM
cord-283427-fef9qsik	3	14	8	8	CD
cord-283427-fef9qsik	3	15	sha	sha	NN
cord-283427-fef9qsik	3	16	:	:	:
cord-283427-fef9qsik	4	1	c494cde4f249216cdacd266d37aaf76fa3b7c1c5	c494cde4f249216cdacd266d37aaf76fa3b7c1c5	NNP
cord-283427-fef9qsik	4	2	doc_id	doc_id	CD
cord-283427-fef9qsik	4	3	:	:	:
cord-283427-fef9qsik	4	4	283427	283427	CD
cord-283427-fef9qsik	5	1	cord_uid	cord_uid	NN
cord-283427-fef9qsik	5	2	:	:	:
cord-283427-fef9qsik	5	3	fef9qsik	fef9qsik	NNP
cord-283427-fef9qsik	6	1	In	in	IN
cord-283427-fef9qsik	6	2	the	the	DT
cord-283427-fef9qsik	6	3	twenty	twenty	CD
cord-283427-fef9qsik	6	4	-	-	HYPH
cord-283427-fef9qsik	6	5	first	first	JJ
cord-283427-fef9qsik	6	6	century	century	NN
cord-283427-fef9qsik	6	7	,	,	,
cord-283427-fef9qsik	6	8	high	high	JJ
cord-283427-fef9qsik	6	9	contagious	contagious	JJ
cord-283427-fef9qsik	6	10	infectious	infectious	JJ
cord-283427-fef9qsik	6	11	diseases	disease	NNS
cord-283427-fef9qsik	6	12	such	such	JJ
cord-283427-fef9qsik	6	13	as	as	IN
cord-283427-fef9qsik	6	14	SARS	SARS	NNP
cord-283427-fef9qsik	7	1	(	(	-LRB-
cord-283427-fef9qsik	7	2	Severe	severe	JJ
cord-283427-fef9qsik	7	3	Acute	acute	JJ
cord-283427-fef9qsik	7	4	Respiratory	Respiratory	NNP
cord-283427-fef9qsik	7	5	Syndrome	Syndrome	NNP
cord-283427-fef9qsik	7	6	)	)	-RRB-
cord-283427-fef9qsik	7	7	,	,	,
cord-283427-fef9qsik	7	8	MERS	MERS	NNP
cord-283427-fef9qsik	7	9	(	(	-LRB-
cord-283427-fef9qsik	7	10	Middle	Middle	NNP
cord-283427-fef9qsik	7	11	East	East	NNP
cord-283427-fef9qsik	7	12	Respiratory	Respiratory	NNP
cord-283427-fef9qsik	7	13	Syndrome	Syndrome	NNP
cord-283427-fef9qsik	7	14	)	)	-RRB-
cord-283427-fef9qsik	7	15	,	,	,
cord-283427-fef9qsik	7	16	FMD	FMD	NNP
cord-283427-fef9qsik	7	17	(	(	-LRB-
cord-283427-fef9qsik	7	18	Foot	Foot	NNP
cord-283427-fef9qsik	7	19	-	-	HYPH
cord-283427-fef9qsik	7	20	and	and	CC
cord-283427-fef9qsik	7	21	-	-	HYPH
cord-283427-fef9qsik	7	22	Mouth	Mouth	NNP
cord-283427-fef9qsik	7	23	Disease	Disease	NNP
cord-283427-fef9qsik	7	24	)	)	-RRB-
cord-283427-fef9qsik	7	25	and	and	CC
cord-283427-fef9qsik	7	26	AI	AI	NNP
cord-283427-fef9qsik	7	27	(	(	-LRB-
cord-283427-fef9qsik	7	28	Avian	Avian	NNP
cord-283427-fef9qsik	7	29	Influenza	Influenza	NNP
cord-283427-fef9qsik	7	30	)	)	-RRB-
cord-283427-fef9qsik	7	31	have	have	VBP
cord-283427-fef9qsik	7	32	become	become	VBN
cord-283427-fef9qsik	7	33	very	very	RB
cord-283427-fef9qsik	7	34	prevalent	prevalent	JJ
cord-283427-fef9qsik	7	35	,	,	,
cord-283427-fef9qsik	7	36	causing	cause	VBG
cord-283427-fef9qsik	7	37	treat	treat	JJ
cord-283427-fef9qsik	7	38	harm	harm	NN
cord-283427-fef9qsik	7	39	to	to	IN
cord-283427-fef9qsik	7	40	humans	human	NNS
cord-283427-fef9qsik	7	41	and	and	CC
cord-283427-fef9qsik	7	42	animals	animal	NNS
cord-283427-fef9qsik	7	43	in	in	IN
cord-283427-fef9qsik	7	44	aspect	aspect	NN
cord-283427-fef9qsik	7	45	of	of	IN
cord-283427-fef9qsik	7	46	public	public	JJ
cord-283427-fef9qsik	7	47	health	health	NN
cord-283427-fef9qsik	7	48	,	,	,
cord-283427-fef9qsik	7	49	and	and	CC
cord-283427-fef9qsik	7	50	economical	economical	JJ
cord-283427-fef9qsik	7	51	issues	issue	NNS
cord-283427-fef9qsik	7	52	.	.	.
cord-283427-fef9qsik	8	1	The	the	DT
cord-283427-fef9qsik	8	2	critical	critical	JJ
cord-283427-fef9qsik	8	3	problem	problem	NN
cord-283427-fef9qsik	8	4	is	be	VBZ
cord-283427-fef9qsik	8	5	that	that	IN
cord-283427-fef9qsik	8	6	newly	newly	RB
cord-283427-fef9qsik	8	7	-	-	HYPH
cord-283427-fef9qsik	8	8	reported	report	VBN
cord-283427-fef9qsik	8	9	infectious	infectious	JJ
cord-283427-fef9qsik	8	10	diseases	disease	NNS
cord-283427-fef9qsik	8	11	that	that	WDT
cord-283427-fef9qsik	8	12	humans	human	NNS
cord-283427-fef9qsik	8	13	firstly	firstly	RB
cord-283427-fef9qsik	8	14	experience	experience	NN
cord-283427-fef9qsik	8	15	are	be	VBP
cord-283427-fef9qsik	8	16	expected	expect	VBN
cord-283427-fef9qsik	8	17	to	to	TO
cord-283427-fef9qsik	8	18	continue	continue	VB
cord-283427-fef9qsik	8	19	to	to	TO
cord-283427-fef9qsik	8	20	emerge	emerge	VB
cord-283427-fef9qsik	8	21	,	,	,
cord-283427-fef9qsik	8	22	and	and	CC
cord-283427-fef9qsik	8	23	these	these	DT
cord-283427-fef9qsik	8	24	diseases	disease	NNS
cord-283427-fef9qsik	8	25	will	will	MD
cord-283427-fef9qsik	8	26	be	be	VB
cord-283427-fef9qsik	8	27	spreading	spread	VBG
cord-283427-fef9qsik	8	28	out	out	RP
cord-283427-fef9qsik	8	29	rapidly	rapidly	RB
cord-283427-fef9qsik	8	30	.	.	.
cord-283427-fef9qsik	9	1	Therefore	therefore	RB
cord-283427-fef9qsik	9	2	,	,	,
cord-283427-fef9qsik	9	3	rapid	rapid	JJ
cord-283427-fef9qsik	9	4	and	and	CC
cord-283427-fef9qsik	9	5	safe	safe	JJ
cord-283427-fef9qsik	9	6	supplies	supply	NNS
cord-283427-fef9qsik	9	7	of	of	IN
cord-283427-fef9qsik	9	8	effective	effective	JJ
cord-283427-fef9qsik	9	9	vaccines	vaccine	NNS
cord-283427-fef9qsik	9	10	are	be	VBP
cord-283427-fef9qsik	9	11	most	most	RBS
cord-283427-fef9qsik	9	12	pivotal	pivotal	JJ
cord-283427-fef9qsik	9	13	to	to	TO
cord-283427-fef9qsik	9	14	prevent	prevent	VB
cord-283427-fef9qsik	9	15	the	the	DT
cord-283427-fef9qsik	9	16	rapid	rapid	JJ
cord-283427-fef9qsik	9	17	prevalent	prevalent	NN
cord-283427-fef9qsik	9	18	of	of	IN
cord-283427-fef9qsik	9	19	new	new	JJ
cord-283427-fef9qsik	9	20	infection	infection	NN
cord-283427-fef9qsik	9	21	,	,	,
cord-283427-fef9qsik	9	22	but	but	CC
cord-283427-fef9qsik	9	23	international	international	JJ
cord-283427-fef9qsik	9	24	standards	standard	NNS
cord-283427-fef9qsik	9	25	or	or	CC
cord-283427-fef9qsik	9	26	assessing	assess	VBG
cord-283427-fef9qsik	9	27	protocol	protocol	NN
cord-283427-fef9qsik	9	28	the	the	DT
cord-283427-fef9qsik	9	29	safety	safety	NN
cord-283427-fef9qsik	9	30	of	of	IN
cord-283427-fef9qsik	9	31	urgent	urgent	JJ
cord-283427-fef9qsik	9	32	vaccines	vaccine	NNS
cord-283427-fef9qsik	9	33	are	be	VBP
cord-283427-fef9qsik	9	34	not	not	RB
cord-283427-fef9qsik	9	35	established	establish	VBN
cord-283427-fef9qsik	9	36	well	well	RB
cord-283427-fef9qsik	9	37	.	.	.
cord-283427-fef9qsik	10	1	In	in	IN
cord-283427-fef9qsik	10	2	our	-PRON-	PRP$
cord-283427-fef9qsik	10	3	previous	previous	JJ
cord-283427-fef9qsik	10	4	study	study	NN
cord-283427-fef9qsik	10	5	,	,	,
cord-283427-fef9qsik	10	6	since	since	IN
cord-283427-fef9qsik	10	7	we	-PRON-	PRP
cord-283427-fef9qsik	10	8	established	establish	VBD
cord-283427-fef9qsik	10	9	a	a	DT
cord-283427-fef9qsik	10	10	module	module	NN
cord-283427-fef9qsik	10	11	to	to	TO
cord-283427-fef9qsik	10	12	assess	assess	VB
cord-283427-fef9qsik	10	13	the	the	DT
cord-283427-fef9qsik	10	14	brain	brain	NN
cord-283427-fef9qsik	10	15	safety	safety	NN
cord-283427-fef9qsik	10	16	of	of	IN
cord-283427-fef9qsik	10	17	urgent	urgent	JJ
cord-283427-fef9qsik	10	18	vaccines	vaccine	NNS
cord-283427-fef9qsik	10	19	,	,	,
cord-283427-fef9qsik	10	20	therefore	therefore	RB
cord-283427-fef9qsik	10	21	,	,	,
cord-283427-fef9qsik	10	22	it	-PRON-	PRP
cord-283427-fef9qsik	10	23	is	be	VBZ
cord-283427-fef9qsik	10	24	necessary	necessary	JJ
cord-283427-fef9qsik	10	25	to	to	TO
cord-283427-fef9qsik	10	26	verify	verify	VB
cord-283427-fef9qsik	10	27	that	that	IN
cord-283427-fef9qsik	10	28	this	this	DT
cord-283427-fef9qsik	10	29	established	establish	VBN
cord-283427-fef9qsik	10	30	module	module	NN
cord-283427-fef9qsik	10	31	for	for	IN
cord-283427-fef9qsik	10	32	assessing	assess	VBG
cord-283427-fef9qsik	10	33	brain	brain	NN
cord-283427-fef9qsik	10	34	safety	safety	NN
cord-283427-fef9qsik	10	35	could	could	MD
cord-283427-fef9qsik	10	36	work	work	VB
cord-283427-fef9qsik	10	37	effectively	effectively	RB
cord-283427-fef9qsik	10	38	in	in	IN
cord-283427-fef9qsik	10	39	commercially	commercially	RB
cord-283427-fef9qsik	10	40	available	available	JJ
cord-283427-fef9qsik	10	41	two	two	CD
cord-283427-fef9qsik	10	42	vaccines	vaccine	NNS
cord-283427-fef9qsik	10	43	(	(	-LRB-
cord-283427-fef9qsik	10	44	one	one	CD
cord-283427-fef9qsik	10	45	killed-	killed-	NN
cord-283427-fef9qsik	10	46	and	and	CC
cord-283427-fef9qsik	10	47	on	on	IN
cord-283427-fef9qsik	10	48	live	live	JJ
cord-283427-fef9qsik	10	49	-	-	HYPH
cord-283427-fef9qsik	10	50	vaccines	vaccine	NNS
cord-283427-fef9qsik	10	51	)	)	-RRB-
cord-283427-fef9qsik	10	52	.	.	.
cord-283427-fef9qsik	11	1	We	-PRON-	PRP
cord-283427-fef9qsik	11	2	compared	compare	VBD
cord-283427-fef9qsik	11	3	the	the	DT
cord-283427-fef9qsik	11	4	results	result	NNS
cord-283427-fef9qsik	11	5	of	of	IN
cord-283427-fef9qsik	11	6	Evans	Evans	NNP
cord-283427-fef9qsik	11	7	blue	blue	JJ
cord-283427-fef9qsik	11	8	(	(	-LRB-
cord-283427-fef9qsik	11	9	EB	EB	NNP
cord-283427-fef9qsik	11	10	)	)	-RRB-
cord-283427-fef9qsik	11	11	assay	assay	NN
cord-283427-fef9qsik	11	12	and	and	CC
cord-283427-fef9qsik	11	13	qPCR	qPCR	NNP
cord-283427-fef9qsik	11	14	analysis	analysis	NN
cord-283427-fef9qsik	11	15	by	by	IN
cord-283427-fef9qsik	11	16	injection	injection	NN
cord-283427-fef9qsik	11	17	of	of	IN
cord-283427-fef9qsik	11	18	two	two	CD
cord-283427-fef9qsik	11	19	kinds	kind	NNS
cord-283427-fef9qsik	11	20	of	of	IN
cord-283427-fef9qsik	11	21	vaccines	vaccine	NNS
cord-283427-fef9qsik	11	22	,	,	,
cord-283427-fef9qsik	11	23	PBS	PBS	NNP
cord-283427-fef9qsik	11	24	and	and	CC
cord-283427-fef9qsik	11	25	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-283427-fef9qsik	11	26	(	(	-LRB-
cord-283427-fef9qsik	11	27	LPS	LPS	NNP
cord-283427-fef9qsik	11	28	)	)	-RRB-
cord-283427-fef9qsik	11	29	under	under	IN
cord-283427-fef9qsik	11	30	the	the	DT
cord-283427-fef9qsik	11	31	condition	condition	NN
cord-283427-fef9qsik	11	32	of	of	IN
cord-283427-fef9qsik	11	33	the	the	DT
cord-283427-fef9qsik	11	34	module	module	NN
cord-283427-fef9qsik	11	35	previously	previously	RB
cord-283427-fef9qsik	11	36	reported	report	VBD
cord-283427-fef9qsik	11	37	.	.	.
cord-283427-fef9qsik	12	1	We	-PRON-	PRP
cord-283427-fef9qsik	12	2	confirmed	confirm	VBD
cord-283427-fef9qsik	12	3	that	that	IN
cord-283427-fef9qsik	12	4	the	the	DT
cord-283427-fef9qsik	12	5	brain	brain	NN
cord-283427-fef9qsik	12	6	safety	safety	NN
cord-283427-fef9qsik	12	7	test	test	NN
cord-283427-fef9qsik	12	8	module	module	NN
cord-283427-fef9qsik	12	9	for	for	IN
cord-283427-fef9qsik	12	10	urgent	urgent	JJ
cord-283427-fef9qsik	12	11	vaccine	vaccine	NN
cord-283427-fef9qsik	12	12	we	-PRON-	PRP
cord-283427-fef9qsik	12	13	established	establish	VBD
cord-283427-fef9qsik	12	14	is	be	VBZ
cord-283427-fef9qsik	12	15	very	very	RB
cord-283427-fef9qsik	12	16	reproducible	reproducible	JJ
cord-283427-fef9qsik	12	17	.	.	.
cord-283427-fef9qsik	13	1	Therefore	therefore	RB
cord-283427-fef9qsik	13	2	,	,	,
cord-283427-fef9qsik	13	3	it	-PRON-	PRP
cord-283427-fef9qsik	13	4	is	be	VBZ
cord-283427-fef9qsik	13	5	believed	believe	VBN
cord-283427-fef9qsik	13	6	that	that	IN
cord-283427-fef9qsik	13	7	this	this	DT
cord-283427-fef9qsik	13	8	vaccine	vaccine	NN
cord-283427-fef9qsik	13	9	safety	safety	NN
cord-283427-fef9qsik	13	10	testing	testing	NN
cord-283427-fef9qsik	13	11	method	method	NN
cord-283427-fef9qsik	13	12	can	can	MD
cord-283427-fef9qsik	13	13	be	be	VB
cord-283427-fef9qsik	13	14	used	use	VBN
cord-283427-fef9qsik	13	15	to	to	TO
cord-283427-fef9qsik	13	16	validate	validate	VB
cord-283427-fef9qsik	13	17	brain	brain	NN
cord-283427-fef9qsik	13	18	safety	safety	NN
cord-283427-fef9qsik	13	19	when	when	WRB
cord-283427-fef9qsik	13	20	prompt	prompt	JJ
cord-283427-fef9qsik	13	21	supply	supply	NN
cord-283427-fef9qsik	13	22	of	of	IN
cord-283427-fef9qsik	13	23	a	a	DT
cord-283427-fef9qsik	13	24	newly	newly	RB
cord-283427-fef9qsik	13	25	developed	develop	VBN
cord-283427-fef9qsik	13	26	vaccines	vaccine	NNS
cord-283427-fef9qsik	13	27	is	be	VBZ
cord-283427-fef9qsik	13	28	needed	need	VBN
cord-283427-fef9qsik	13	29	.	.	.
cord-283427-fef9qsik	14	1	Recently	recently	RB
cord-283427-fef9qsik	14	2	,	,	,
cord-283427-fef9qsik	14	3	a	a	DT
cord-283427-fef9qsik	14	4	variety	variety	NN
cord-283427-fef9qsik	14	5	of	of	IN
cord-283427-fef9qsik	14	6	infectious	infectious	JJ
cord-283427-fef9qsik	14	7	diseases	disease	NNS
cord-283427-fef9qsik	14	8	with	with	IN
cord-283427-fef9qsik	14	9	high	high	JJ
cord-283427-fef9qsik	14	10	rates	rate	NNS
cord-283427-fef9qsik	14	11	of	of	IN
cord-283427-fef9qsik	14	12	spread	spread	NN
cord-283427-fef9qsik	14	13	and	and	CC
cord-283427-fef9qsik	14	14	mortality	mortality	NN
cord-283427-fef9qsik	14	15	have	have	VBP
cord-283427-fef9qsik	14	16	been	be	VBN
cord-283427-fef9qsik	14	17	frequent	frequent	JJ
cord-283427-fef9qsik	14	18	.	.	.
cord-283427-fef9qsik	15	1	In	in	IN
cord-283427-fef9qsik	15	2	addition	addition	NN
cord-283427-fef9qsik	15	3	,	,	,
cord-283427-fef9qsik	15	4	it	-PRON-	PRP
cord-283427-fef9qsik	15	5	has	have	VBZ
cord-283427-fef9qsik	15	6	been	be	VBN
cord-283427-fef9qsik	15	7	reported	report	VBN
cord-283427-fef9qsik	15	8	that	that	IN
cord-283427-fef9qsik	15	9	high	high	JJ
cord-283427-fef9qsik	15	10	contagious	contagious	JJ
cord-283427-fef9qsik	15	11	infectious	infectious	JJ
cord-283427-fef9qsik	15	12	diseases	disease	NNS
cord-283427-fef9qsik	15	13	are	be	VBP
cord-283427-fef9qsik	15	14	spreading	spread	VBG
cord-283427-fef9qsik	15	15	through	through	IN
cord-283427-fef9qsik	15	16	various	various	JJ
cord-283427-fef9qsik	15	17	routes	route	NNS
cord-283427-fef9qsik	15	18	and	and	CC
cord-283427-fef9qsik	15	19	carriers	carrier	NNS
cord-283427-fef9qsik	15	20	for	for	IN
cord-283427-fef9qsik	15	21	recent	recent	JJ
cord-283427-fef9qsik	15	22	two	two	CD
cord-283427-fef9qsik	15	23	decades	decade	NNS
cord-283427-fef9qsik	15	24	.	.	.
cord-283427-fef9qsik	16	1	It	-PRON-	PRP
cord-283427-fef9qsik	16	2	is	be	VBZ
cord-283427-fef9qsik	16	3	important	important	JJ
cord-283427-fef9qsik	16	4	to	to	TO
cord-283427-fef9qsik	16	5	prevent	prevent	VB
cord-283427-fef9qsik	16	6	from	from	IN
cord-283427-fef9qsik	16	7	spreading	spread	VBG
cord-283427-fef9qsik	16	8	out	out	RP
cord-283427-fef9qsik	16	9	a	a	DT
cord-283427-fef9qsik	16	10	number	number	NN
cord-283427-fef9qsik	16	11	of	of	IN
cord-283427-fef9qsik	16	12	infectious	infectious	JJ
cord-283427-fef9qsik	16	13	diseases	disease	NNS
cord-283427-fef9qsik	16	14	earlier	early	RBR
cord-283427-fef9qsik	16	15	in	in	IN
cord-283427-fef9qsik	16	16	the	the	DT
cord-283427-fef9qsik	16	17	outbreak	outbreak	NN
cord-283427-fef9qsik	16	18	of	of	IN
cord-283427-fef9qsik	16	19	the	the	DT
cord-283427-fef9qsik	16	20	causing	cause	VBG
cord-283427-fef9qsik	16	21	agents	agent	NNS
cord-283427-fef9qsik	16	22	because	because	IN
cord-283427-fef9qsik	16	23	of	of	IN
cord-283427-fef9qsik	16	24	our	-PRON-	PRP$
cord-283427-fef9qsik	16	25	rapid	rapid	JJ
cord-283427-fef9qsik	16	26	transportation	transportation	NN
cord-283427-fef9qsik	16	27	population	population	NN
cord-283427-fef9qsik	16	28	density	density	NN
cord-283427-fef9qsik	16	29	.	.	.
cord-283427-fef9qsik	17	1	Therefore	therefore	RB
cord-283427-fef9qsik	17	2	,	,	,
cord-283427-fef9qsik	17	3	prompt	prompt	JJ
cord-283427-fef9qsik	17	4	supplying	supplying	NN
cord-283427-fef9qsik	17	5	of	of	IN
cord-283427-fef9qsik	17	6	vaccines	vaccine	NNS
cord-283427-fef9qsik	17	7	should	should	MD
cord-283427-fef9qsik	17	8	be	be	VB
cord-283427-fef9qsik	17	9	secured	secure	VBN
cord-283427-fef9qsik	17	10	within	within	IN
cord-283427-fef9qsik	17	11	a	a	DT
cord-283427-fef9qsik	17	12	limit	limit	NN
cord-283427-fef9qsik	17	13	time	time	NN
cord-283427-fef9qsik	17	14	,	,	,
cord-283427-fef9qsik	17	15	even	even	RB
cord-283427-fef9qsik	17	16	at	at	IN
cord-283427-fef9qsik	17	17	unexpected	unexpected	JJ
cord-283427-fef9qsik	17	18	times	time	NNS
cord-283427-fef9qsik	17	19	and	and	CC
cord-283427-fef9qsik	17	20	places	place	NNS
cord-283427-fef9qsik	17	21	.	.	.
cord-283427-fef9qsik	18	1	The	the	DT
cord-283427-fef9qsik	18	2	speed	speed	NN
cord-283427-fef9qsik	18	3	of	of	IN
cord-283427-fef9qsik	18	4	vaccine	vaccine	NN
cord-283427-fef9qsik	18	5	development	development	NN
cord-283427-fef9qsik	18	6	is	be	VBZ
cord-283427-fef9qsik	18	7	also	also	RB
cord-283427-fef9qsik	18	8	a	a	DT
cord-283427-fef9qsik	18	9	very	very	RB
cord-283427-fef9qsik	18	10	critical	critical	JJ
cord-283427-fef9qsik	18	11	issue	issue	NN
cord-283427-fef9qsik	18	12	.	.	.
cord-283427-fef9qsik	19	1	Thus	thus	RB
cord-283427-fef9qsik	19	2	,	,	,
cord-283427-fef9qsik	19	3	safety	safety	NN
cord-283427-fef9qsik	19	4	of	of	IN
cord-283427-fef9qsik	19	5	the	the	DT
cord-283427-fef9qsik	19	6	vaccines	vaccine	NNS
cord-283427-fef9qsik	19	7	also	also	RB
cord-283427-fef9qsik	19	8	should	should	MD
cord-283427-fef9qsik	19	9	be	be	VB
cord-283427-fef9qsik	19	10	assured	assure	VBN
cord-283427-fef9qsik	19	11	.	.	.
cord-283427-fef9qsik	20	1	Nevertheless	nevertheless	RB
cord-283427-fef9qsik	20	2	,	,	,
cord-283427-fef9qsik	20	3	it	-PRON-	PRP
cord-283427-fef9qsik	20	4	is	be	VBZ
cord-283427-fef9qsik	20	5	difficult	difficult	JJ
cord-283427-fef9qsik	20	6	to	to	TO
cord-283427-fef9qsik	20	7	obtain	obtain	VB
cord-283427-fef9qsik	20	8	sufficient	sufficient	JJ
cord-283427-fef9qsik	20	9	time	time	NN
cord-283427-fef9qsik	20	10	to	to	TO
cord-283427-fef9qsik	20	11	perform	perform	VB
cord-283427-fef9qsik	20	12	a	a	DT
cord-283427-fef9qsik	20	13	complete	complete	JJ
cord-283427-fef9qsik	20	14	safety	safety	NN
cord-283427-fef9qsik	20	15	evaluation	evaluation	NN
cord-283427-fef9qsik	20	16	for	for	IN
cord-283427-fef9qsik	20	17	a	a	DT
cord-283427-fef9qsik	20	18	rapid	rapid	JJ
cord-283427-fef9qsik	20	19	supply	supply	NN
cord-283427-fef9qsik	20	20	of	of	IN
cord-283427-fef9qsik	20	21	urgent	urgent	JJ
cord-283427-fef9qsik	20	22	vaccines	vaccine	NNS
cord-283427-fef9qsik	20	23	.	.	.
cord-283427-fef9qsik	21	1	It	-PRON-	PRP
cord-283427-fef9qsik	21	2	is	be	VBZ
cord-283427-fef9qsik	21	3	very	very	RB
cord-283427-fef9qsik	21	4	unfortunate	unfortunate	JJ
cord-283427-fef9qsik	21	5	that	that	IN
cord-283427-fef9qsik	21	6	we	-PRON-	PRP
cord-283427-fef9qsik	21	7	have	have	VBP
cord-283427-fef9qsik	21	8	already	already	RB
cord-283427-fef9qsik	21	9	mentioned	mention	VBN
cord-283427-fef9qsik	21	10	in	in	IN
cord-283427-fef9qsik	21	11	the	the	DT
cord-283427-fef9qsik	21	12	previous	previous	JJ
cord-283427-fef9qsik	21	13	report	report	NN
cord-283427-fef9qsik	21	14	that	that	IN
cord-283427-fef9qsik	21	15	there	there	EX
cord-283427-fef9qsik	21	16	is	be	VBZ
cord-283427-fef9qsik	21	17	not	not	RB
cord-283427-fef9qsik	21	18	global	global	JJ
cord-283427-fef9qsik	21	19	standard	standard	NN
cord-283427-fef9qsik	21	20	for	for	IN
cord-283427-fef9qsik	21	21	the	the	DT
cord-283427-fef9qsik	21	22	safety	safety	NN
cord-283427-fef9qsik	21	23	assessment	assessment	NN
cord-283427-fef9qsik	21	24	of	of	IN
cord-283427-fef9qsik	21	25	these	these	DT
cord-283427-fef9qsik	21	26	newly	newly	RB
cord-283427-fef9qsik	21	27	develop	develop	VBP
cord-283427-fef9qsik	21	28	urgent	urgent	JJ
cord-283427-fef9qsik	21	29	vaccines	vaccine	NNS
cord-283427-fef9qsik	21	30	.	.	.
cord-283427-fef9qsik	22	1	In	in	IN
cord-283427-fef9qsik	22	2	our	-PRON-	PRP$
cord-283427-fef9qsik	22	3	previous	previous	JJ
cord-283427-fef9qsik	22	4	study	study	NN
cord-283427-fef9qsik	22	5	,	,	,
cord-283427-fef9qsik	22	6	we	-PRON-	PRP
cord-283427-fef9qsik	22	7	established	establish	VBD
cord-283427-fef9qsik	22	8	of	of	IN
cord-283427-fef9qsik	22	9	minimal	minimal	JJ
cord-283427-fef9qsik	22	10	positive	positive	JJ
cord-283427-fef9qsik	22	11	control	control	NN
cord-283427-fef9qsik	22	12	conditions	condition	NNS
cord-283427-fef9qsik	22	13	to	to	TO
cord-283427-fef9qsik	22	14	ensure	ensure	VB
cord-283427-fef9qsik	22	15	brain	brain	NN
cord-283427-fef9qsik	22	16	safety	safety	NN
cord-283427-fef9qsik	22	17	using	use	VBG
cord-283427-fef9qsik	22	18	experimental	experimental	JJ
cord-283427-fef9qsik	22	19	mice	mice	NN
cord-283427-fef9qsik	22	20	models	model	NNS
cord-283427-fef9qsik	22	21	during	during	IN
cord-283427-fef9qsik	22	22	development	development	NN
cord-283427-fef9qsik	22	23	of	of	IN
cord-283427-fef9qsik	22	24	urgent	urgent	JJ
cord-283427-fef9qsik	22	25	vaccines	vaccine	NNS
cord-283427-fef9qsik	22	26	before	before	IN
cord-283427-fef9qsik	22	27	introducing	introduce	VBG
cord-283427-fef9qsik	22	28	to	to	IN
cord-283427-fef9qsik	22	29	markets	market	NNS
cord-283427-fef9qsik	22	30	.	.	.
cord-283427-fef9qsik	23	1	We	-PRON-	PRP
cord-283427-fef9qsik	23	2	conducted	conduct	VBD
cord-283427-fef9qsik	23	3	several	several	JJ
cord-283427-fef9qsik	23	4	experiments	experiment	NNS
cord-283427-fef9qsik	23	5	to	to	TO
cord-283427-fef9qsik	23	6	evaluate	evaluate	VB
cord-283427-fef9qsik	23	7	the	the	DT
cord-283427-fef9qsik	23	8	safety	safety	NN
cord-283427-fef9qsik	23	9	of	of	IN
cord-283427-fef9qsik	23	10	vaccines	vaccine	NNS
cord-283427-fef9qsik	23	11	,	,	,
cord-283427-fef9qsik	23	12	and	and	CC
cord-283427-fef9qsik	23	13	presented	present	VBD
cord-283427-fef9qsik	23	14	the	the	DT
cord-283427-fef9qsik	23	15	ideal	ideal	JJ
cord-283427-fef9qsik	23	16	combination	combination	NN
cord-283427-fef9qsik	23	17	of	of	IN
cord-283427-fef9qsik	23	18	the	the	DT
cord-283427-fef9qsik	23	19	experiments	experiment	NNS
cord-283427-fef9qsik	23	20	:	:	:
cord-283427-fef9qsik	23	21	susceptible	susceptible	JJ
cord-283427-fef9qsik	23	22	mice	mice	NN
cord-283427-fef9qsik	23	23	types	type	NNS
cord-283427-fef9qsik	23	24	according	accord	VBG
cord-283427-fef9qsik	23	25	to	to	IN
cord-283427-fef9qsik	23	26	the	the	DT
cord-283427-fef9qsik	23	27	effective	effective	JJ
cord-283427-fef9qsik	23	28	concentration	concentration	NN
cord-283427-fef9qsik	23	29	of	of	IN
cord-283427-fef9qsik	23	30	lipopolysaccharide	lipopolysaccharide	NN
cord-283427-fef9qsik	23	31	(	(	-LRB-
cord-283427-fef9qsik	23	32	LPS	LPS	NNP
cord-283427-fef9qsik	23	33	)	)	-RRB-
cord-283427-fef9qsik	23	34	destroying	destroy	VBG
cord-283427-fef9qsik	23	35	Bloodbrain	Bloodbrain	NNP
cord-283427-fef9qsik	23	36	barrier	barrier	NN
cord-283427-fef9qsik	23	37	(	(	-LRB-
cord-283427-fef9qsik	23	38	BBB	BBB	NNP
cord-283427-fef9qsik	23	39	)	)	-RRB-
cord-283427-fef9qsik	23	40	,	,	,
cord-283427-fef9qsik	23	41	the	the	DT
cord-283427-fef9qsik	23	42	appropriate	appropriate	JJ
cord-283427-fef9qsik	23	43	LPS	LPS	NNP
cord-283427-fef9qsik	23	44	exposure	exposure	NN
cord-283427-fef9qsik	23	45	time	time	NN
cord-283427-fef9qsik	23	46	destroying	destroy	VBG
cord-283427-fef9qsik	23	47	BBB	BBB	NNP
cord-283427-fef9qsik	23	48	,	,	,
cord-283427-fef9qsik	23	49	origin	origin	NN
cord-283427-fef9qsik	23	50	type	type	NN
cord-283427-fef9qsik	23	51	of	of	IN
cord-283427-fef9qsik	23	52	LPS	LPS	NNP
cord-283427-fef9qsik	23	53	(	(	-LRB-
cord-283427-fef9qsik	23	54	Salmonella	Salmonella	NNP
cord-283427-fef9qsik	23	55	enterica	enterica	NNP
cord-283427-fef9qsik	23	56	)	)	-RRB-
cord-283427-fef9qsik	23	57	,	,	,
cord-283427-fef9qsik	23	58	and	and	CC
cord-283427-fef9qsik	23	59	injection	injection	NN
cord-283427-fef9qsik	23	60	route	route	NN
cord-283427-fef9qsik	23	61	of	of	IN
cord-283427-fef9qsik	23	62	LPS	LPS	NNP
cord-283427-fef9qsik	23	63	.	.	.
cord-283427-fef9qsik	24	1	In	in	IN
cord-283427-fef9qsik	24	2	this	this	DT
cord-283427-fef9qsik	24	3	study	study	NN
cord-283427-fef9qsik	24	4	,	,	,
cord-283427-fef9qsik	24	5	we	-PRON-	PRP
cord-283427-fef9qsik	24	6	tried	try	VBD
cord-283427-fef9qsik	24	7	to	to	TO
cord-283427-fef9qsik	24	8	evaluate	evaluate	VB
cord-283427-fef9qsik	24	9	whether	whether	IN
cord-283427-fef9qsik	24	10	the	the	DT
cord-283427-fef9qsik	24	11	previously	previously	RB
cord-283427-fef9qsik	24	12	established	establish	VBN
cord-283427-fef9qsik	24	13	assessment	assessment	NN
cord-283427-fef9qsik	24	14	method	method	NN
cord-283427-fef9qsik	24	15	could	could	MD
cord-283427-fef9qsik	24	16	be	be	VB
cord-283427-fef9qsik	24	17	available	available	JJ
cord-283427-fef9qsik	24	18	for	for	IN
cord-283427-fef9qsik	24	19	evaluating	evaluate	VBG
cord-283427-fef9qsik	24	20	brain	brain	NN
cord-283427-fef9qsik	24	21	safety	safety	NN
cord-283427-fef9qsik	24	22	rapidly	rapidly	RB
cord-283427-fef9qsik	24	23	with	with	IN
cord-283427-fef9qsik	24	24	two	two	CD
cord-283427-fef9qsik	24	25	commercial	commercial	JJ
cord-283427-fef9qsik	24	26	vaccines	vaccine	NNS
cord-283427-fef9qsik	24	27	easily	easily	RB
cord-283427-fef9qsik	24	28	accessible	accessible	JJ
cord-283427-fef9qsik	24	29	vaccines	vaccine	NNS
cord-283427-fef9qsik	24	30	(	(	-LRB-
cord-283427-fef9qsik	24	31	a	a	DT
cord-283427-fef9qsik	24	32	killed	kill	VBN
cord-283427-fef9qsik	24	33	-	-	:
cord-283427-fef9qsik	24	34	and	and	CC
cord-283427-fef9qsik	24	35	a	a	DT
cord-283427-fef9qsik	24	36	live	live	JJ
cord-283427-fef9qsik	24	37	-	-	HYPH
cord-283427-fef9qsik	24	38	vaccine	vaccine	NN
cord-283427-fef9qsik	24	39	)	)	-RRB-
cord-283427-fef9qsik	24	40	.	.	.
cord-283427-fef9qsik	25	1	We	-PRON-	PRP
cord-283427-fef9qsik	25	2	confirmed	confirm	VBD
cord-283427-fef9qsik	25	3	in	in	IN
cord-283427-fef9qsik	25	4	the	the	DT
cord-283427-fef9qsik	25	5	present	present	JJ
cord-283427-fef9qsik	25	6	study	study	NN
cord-283427-fef9qsik	25	7	that	that	IN
cord-283427-fef9qsik	25	8	the	the	DT
cord-283427-fef9qsik	25	9	pre	pre	NN
cord-283427-fef9qsik	25	10	-	-	JJ
cord-283427-fef9qsik	25	11	established	establish	VBN
cord-283427-fef9qsik	25	12	"	"	``
cord-283427-fef9qsik	25	13	vaccine	vaccine	NN
cord-283427-fef9qsik	25	14	safety	safety	NN
cord-283427-fef9qsik	25	15	module	module	NN
cord-283427-fef9qsik	25	16	for	for	IN
cord-283427-fef9qsik	25	17	the	the	DT
cord-283427-fef9qsik	25	18	brain	brain	NN
cord-283427-fef9qsik	25	19	"	"	``
cord-283427-fef9qsik	25	20	was	be	VBD
cord-283427-fef9qsik	25	21	highly	highly	RB
cord-283427-fef9qsik	25	22	reproducible	reproducible	JJ
cord-283427-fef9qsik	25	23	in	in	IN
cord-283427-fef9qsik	25	24	the	the	DT
cord-283427-fef9qsik	25	25	evaluation	evaluation	NN
cord-283427-fef9qsik	25	26	of	of	IN
cord-283427-fef9qsik	25	27	the	the	DT
cord-283427-fef9qsik	25	28	safety	safety	NN
cord-283427-fef9qsik	25	29	results	result	NNS
cord-283427-fef9qsik	25	30	by	by	IN
cord-283427-fef9qsik	25	31	the	the	DT
cord-283427-fef9qsik	25	32	commercially	commercially	RB
cord-283427-fef9qsik	25	33	available	available	JJ
cord-283427-fef9qsik	25	34	vaccines	vaccine	NNS
cord-283427-fef9qsik	25	35	.	.	.
cord-283427-fef9qsik	26	1	In	in	IN
cord-283427-fef9qsik	26	2	this	this	DT
cord-283427-fef9qsik	26	3	study	study	NN
cord-283427-fef9qsik	26	4	,	,	,
cord-283427-fef9qsik	26	5	we	-PRON-	PRP
cord-283427-fef9qsik	26	6	described	describe	VBD
cord-283427-fef9qsik	26	7	that	that	IN
cord-283427-fef9qsik	26	8	this	this	DT
cord-283427-fef9qsik	26	9	module	module	NN
cord-283427-fef9qsik	26	10	can	can	MD
cord-283427-fef9qsik	26	11	be	be	VB
cord-283427-fef9qsik	26	12	useful	useful	JJ
cord-283427-fef9qsik	26	13	in	in	IN
cord-283427-fef9qsik	26	14	applying	apply	VBG
cord-283427-fef9qsik	26	15	a	a	DT
cord-283427-fef9qsik	26	16	commercially	commercially	RB
cord-283427-fef9qsik	26	17	available	available	JJ
cord-283427-fef9qsik	26	18	vaccine	vaccine	NN
cord-283427-fef9qsik	26	19	to	to	IN
cord-283427-fef9qsik	26	20	a	a	DT
cord-283427-fef9qsik	26	21	rapid	rapid	JJ
cord-283427-fef9qsik	26	22	and	and	CC
cord-283427-fef9qsik	26	23	effective	effective	JJ
cord-283427-fef9qsik	26	24	positive	positive	JJ
cord-283427-fef9qsik	26	25	-	-	HYPH
cord-283427-fef9qsik	26	26	control	control	NN
cord-283427-fef9qsik	26	27	for	for	IN
cord-283427-fef9qsik	26	28	brain	brain	NN
cord-283427-fef9qsik	26	29	safety	safety	NN
cord-283427-fef9qsik	26	30	assessment	assessment	NN
cord-283427-fef9qsik	26	31	of	of	IN
cord-283427-fef9qsik	26	32	an	an	DT
cord-283427-fef9qsik	26	33	urgent	urgent	JJ
cord-283427-fef9qsik	26	34	vaccine	vaccine	NN
cord-283427-fef9qsik	26	35	.	.	.
cord-283427-fef9qsik	27	1	This	this	DT
cord-283427-fef9qsik	27	2	study	study	NN
cord-283427-fef9qsik	27	3	will	will	MD
cord-283427-fef9qsik	27	4	be	be	VB
cord-283427-fef9qsik	27	5	of	of	IN
cord-283427-fef9qsik	27	6	great	great	JJ
cord-283427-fef9qsik	27	7	help	help	NN
cord-283427-fef9qsik	27	8	to	to	TO
cord-283427-fef9qsik	27	9	ensure	ensure	VB
cord-283427-fef9qsik	27	10	that	that	IN
cord-283427-fef9qsik	27	11	vaccines	vaccine	NNS
cord-283427-fef9qsik	27	12	should	should	MD
cord-283427-fef9qsik	27	13	be	be	VB
cord-283427-fef9qsik	27	14	urgently	urgently	RB
cord-283427-fef9qsik	27	15	and	and	CC
cord-283427-fef9qsik	27	16	promptly	promptly	RB
cord-283427-fef9qsik	27	17	distributed	distribute	VBN
cord-283427-fef9qsik	27	18	to	to	IN
cord-283427-fef9qsik	27	19	public	public	NN
cord-283427-fef9qsik	27	20	with	with	IN
cord-283427-fef9qsik	27	21	assured	assured	JJ
cord-283427-fef9qsik	27	22	minimal	minimal	JJ
cord-283427-fef9qsik	27	23	safety	safety	NN
cord-283427-fef9qsik	27	24	of	of	IN
cord-283427-fef9qsik	27	25	brain	brain	NN
cord-283427-fef9qsik	27	26	at	at	IN
cord-283427-fef9qsik	27	27	an	an	DT
cord-283427-fef9qsik	27	28	unexpected	unexpected	JJ
cord-283427-fef9qsik	27	29	outbreak	outbreak	NN
cord-283427-fef9qsik	27	30	of	of	IN
cord-283427-fef9qsik	27	31	certain	certain	JJ
cord-283427-fef9qsik	27	32	infectious	infectious	JJ
cord-283427-fef9qsik	27	33	diseases	disease	NNS
cord-283427-fef9qsik	27	34	in	in	IN
cord-283427-fef9qsik	27	35	human	human	JJ
cord-283427-fef9qsik	27	36	and	and	CC
cord-283427-fef9qsik	27	37	veterinary	veterinary	JJ
cord-283427-fef9qsik	27	38	fields	field	NNS
cord-283427-fef9qsik	27	39	.	.	.
cord-283427-fef9qsik	28	1	Most	Most	JJS
cord-283427-fef9qsik	28	2	of	of	IN
cord-283427-fef9qsik	28	3	experiments	experiment	NNS
cord-283427-fef9qsik	28	4	were	be	VBD
cord-283427-fef9qsik	28	5	performed	perform	VBN
cord-283427-fef9qsik	28	6	based	base	VBN
cord-283427-fef9qsik	28	7	on	on	IN
cord-283427-fef9qsik	28	8	our	-PRON-	PRP$
cord-283427-fef9qsik	28	9	previous	previous	JJ
cord-283427-fef9qsik	28	10	study	study	NN
cord-283427-fef9qsik	28	11	.	.	.
cord-283427-fef9qsik	29	1	Among	among	IN
cord-283427-fef9qsik	29	2	the	the	DT
cord-283427-fef9qsik	29	3	experiments	experiment	NNS
cord-283427-fef9qsik	29	4	,	,	,
cord-283427-fef9qsik	29	5	we	-PRON-	PRP
cord-283427-fef9qsik	29	6	primarily	primarily	RB
cord-283427-fef9qsik	29	7	chose	choose	VBD
cord-283427-fef9qsik	29	8	some	some	DT
cord-283427-fef9qsik	29	9	combinations	combination	NNS
cord-283427-fef9qsik	29	10	that	that	WDT
cord-283427-fef9qsik	29	11	we	-PRON-	PRP
cord-283427-fef9qsik	29	12	'd	'd	MD
cord-283427-fef9qsik	29	13	suggested	suggest	VBN
cord-283427-fef9qsik	29	14	in	in	IN
cord-283427-fef9qsik	29	15	the	the	DT
cord-283427-fef9qsik	29	16	previous	previous	JJ
cord-283427-fef9qsik	29	17	reports	report	NNS
cord-283427-fef9qsik	29	18	by	by	IN
cord-283427-fef9qsik	29	19	Baek	Baek	NNP
cord-283427-fef9qsik	29	20	et	et	NNP
cord-283427-fef9qsik	29	21	al	al	NNP
cord-283427-fef9qsik	29	22	.	.	NNP
cord-283427-fef9qsik	29	23	,	,	,
cord-283427-fef9qsik	29	24	[	[	-LRB-
cord-283427-fef9qsik	29	25	1	1	CD
cord-283427-fef9qsik	29	26	]	]	-RRB-
cord-283427-fef9qsik	29	27	.	.	.
cord-283427-fef9qsik	30	1	In	in	IN
cord-283427-fef9qsik	30	2	brief	brief	NN
cord-283427-fef9qsik	30	3	,	,	,
cord-283427-fef9qsik	30	4	evidences	evidence	NNS
cord-283427-fef9qsik	30	5	for	for	IN
cord-283427-fef9qsik	30	6	the	the	DT
cord-283427-fef9qsik	30	7	BBB	BBB	NNP
cord-283427-fef9qsik	30	8	damage	damage	NN
cord-283427-fef9qsik	30	9	by	by	IN
cord-283427-fef9qsik	30	10	commercially	commercially	RB
cord-283427-fef9qsik	30	11	available	available	JJ
cord-283427-fef9qsik	30	12	vaccines	vaccine	NNS
cord-283427-fef9qsik	30	13	(	(	-LRB-
cord-283427-fef9qsik	30	14	killed	kill	VBN
cord-283427-fef9qsik	30	15	porcine	porcine	JJ
cord-283427-fef9qsik	30	16	genital	genital	JJ
cord-283427-fef9qsik	30	17	respiratory	respiratory	JJ
cord-283427-fef9qsik	30	18	syndrome	syndrome	NN
cord-283427-fef9qsik	30	19	vaccine	vaccine	NN
cord-283427-fef9qsik	30	20	vaccine	vaccine	NN
cord-283427-fef9qsik	30	21	and	and	CC
cord-283427-fef9qsik	30	22	live	live	JJ
cord-283427-fef9qsik	30	23	canine	canine	JJ
cord-283427-fef9qsik	30	24	parvovirus	parvovirus	NN
cord-283427-fef9qsik	30	25	vaccine	vaccine	NN
cord-283427-fef9qsik	30	26	)	)	-RRB-
cord-283427-fef9qsik	30	27	were	be	VBD
cord-283427-fef9qsik	30	28	based	base	VBN
cord-283427-fef9qsik	30	29	on	on	IN
cord-283427-fef9qsik	30	30	Evans	Evans	NNP
cord-283427-fef9qsik	30	31	blue	blue	JJ
cord-283427-fef9qsik	30	32	EB	EB	NNP
cord-283427-fef9qsik	30	33	permeability	permeability	NN
cord-283427-fef9qsik	30	34	into	into	IN
cord-283427-fef9qsik	30	35	brain	brain	NN
cord-283427-fef9qsik	30	36	parenchyma	parenchyma	NN
cord-283427-fef9qsik	30	37	and	and	CC
cord-283427-fef9qsik	30	38	mRNA	mrna	NN
cord-283427-fef9qsik	30	39	expression	expression	NN
cord-283427-fef9qsik	30	40	of	of	IN
cord-283427-fef9qsik	30	41	tight	tight	JJ
cord-283427-fef9qsik	30	42	junctions	junction	NNS
cord-283427-fef9qsik	30	43	(	(	-LRB-
cord-283427-fef9qsik	30	44	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	30	45	and	and	CC
cord-283427-fef9qsik	30	46	Occludin	Occludin	NNP
cord-283427-fef9qsik	30	47	)	)	-RRB-
cord-283427-fef9qsik	30	48	in	in	IN
cord-283427-fef9qsik	30	49	the	the	DT
cord-283427-fef9qsik	30	50	brain	brain	NN
cord-283427-fef9qsik	30	51	.	.	.
cord-283427-fef9qsik	31	1	Experimental	experimental	JJ
cord-283427-fef9qsik	31	2	method	method	NN
cord-283427-fef9qsik	31	3	for	for	IN
cord-283427-fef9qsik	31	4	this	this	DT
cord-283427-fef9qsik	31	5	is	be	VBZ
cord-283427-fef9qsik	31	6	described	describe	VBN
cord-283427-fef9qsik	31	7	in	in	IN
cord-283427-fef9qsik	31	8	detail	detail	NN
cord-283427-fef9qsik	31	9	below	below	RB
cord-283427-fef9qsik	31	10	.	.	.
cord-283427-fef9qsik	32	1	Evans	Evans	NNP
cord-283427-fef9qsik	32	2	blue	blue	JJ
cord-283427-fef9qsik	32	3	(	(	-LRB-
cord-283427-fef9qsik	32	4	EB	EB	NNP
cord-283427-fef9qsik	32	5	)	)	-RRB-
cord-283427-fef9qsik	32	6	assay	assay	NN
cord-283427-fef9qsik	32	7	for	for	IN
cord-283427-fef9qsik	32	8	brain	brain	NN
cord-283427-fef9qsik	32	9	permeability	permeability	NN
cord-283427-fef9qsik	33	1	Seven	seven	CD
cord-283427-fef9qsik	33	2	-	-	HYPH
cord-283427-fef9qsik	33	3	weeks	week	NNS
cord-283427-fef9qsik	33	4	old	old	JJ
cord-283427-fef9qsik	33	5	ICR	ICR	NNP
cord-283427-fef9qsik	33	6	mice	mouse	NNS
cord-283427-fef9qsik	33	7	and	and	CC
cord-283427-fef9qsik	33	8	LPS	LPS	NNP
cord-283427-fef9qsik	33	9	sources	source	NNS
cord-283427-fef9qsik	34	1	Salmonella	Salmonella	NNP
cord-283427-fef9qsik	34	2	enterica	enterica	NNP
cord-283427-fef9qsik	34	3	were	be	VBD
cord-283427-fef9qsik	34	4	used	use	VBN
cord-283427-fef9qsik	34	5	.	.	.
cord-283427-fef9qsik	35	1	LPS	LPS	NNP
cord-283427-fef9qsik	35	2	solutions	solution	NNS
cord-283427-fef9qsik	35	3	concentration	concentration	NN
cord-283427-fef9qsik	35	4	was	be	VBD
cord-283427-fef9qsik	35	5	1.0	1.0	CD
cord-283427-fef9qsik	35	6	mg/4	mg/4	CD
cord-283427-fef9qsik	35	7	ml	ml	NN
cord-283427-fef9qsik	35	8	/	/	SYM
cord-283427-fef9qsik	35	9	kg	kg	NNP
cord-283427-fef9qsik	35	10	,	,	,
cord-283427-fef9qsik	35	11	and	and	CC
cord-283427-fef9qsik	35	12	i.p	i.p	NNP
cord-283427-fef9qsik	35	13	injection	injection	NN
cord-283427-fef9qsik	35	14	was	be	VBD
cord-283427-fef9qsik	35	15	performed	perform	VBN
cord-283427-fef9qsik	35	16	.	.	.
cord-283427-fef9qsik	36	1	The	the	DT
cord-283427-fef9qsik	36	2	LPS	LPS	NNP
cord-283427-fef9qsik	36	3	from	from	IN
cord-283427-fef9qsik	36	4	S.enterica	s.enterica	JJ
cord-283427-fef9qsik	36	5	serotype	serotype	NN
cord-283427-fef9qsik	36	6	enteritidis	enteritidis	NN
cord-283427-fef9qsik	36	7	(	(	-LRB-
cord-283427-fef9qsik	36	8	L6011	L6011	NNP
cord-283427-fef9qsik	36	9	;	;	:
cord-283427-fef9qsik	36	10	Sigma	Sigma	NNP
cord-283427-fef9qsik	36	11	,	,	,
cord-283427-fef9qsik	36	12	USA	USA	NNP
cord-283427-fef9qsik	36	13	)	)	-RRB-
cord-283427-fef9qsik	36	14	was	be	VBD
cord-283427-fef9qsik	36	15	dissolved	dissolve	VBN
cord-283427-fef9qsik	36	16	in	in	IN
cord-283427-fef9qsik	36	17	phosphate	phosphate	NN
cord-283427-fef9qsik	36	18	buffered	buffer	VBN
cord-283427-fef9qsik	36	19	saline	saline	NN
cord-283427-fef9qsik	36	20	(	(	-LRB-
cord-283427-fef9qsik	36	21	PBS	PBS	NNP
cord-283427-fef9qsik	36	22	;	;	:
cord-283427-fef9qsik	36	23	pH	pH	NNP
cord-283427-fef9qsik	36	24	7.4	7.4	CD
cord-283427-fef9qsik	36	25	)	)	-RRB-
cord-283427-fef9qsik	36	26	.	.	.
cord-283427-fef9qsik	37	1	Two	two	CD
cord-283427-fef9qsik	37	2	types	type	NNS
cord-283427-fef9qsik	37	3	of	of	IN
cord-283427-fef9qsik	37	4	commercially	commercially	RB
cord-283427-fef9qsik	37	5	available	available	JJ
cord-283427-fef9qsik	37	6	vaccines	vaccine	NNS
cord-283427-fef9qsik	37	7	were	be	VBD
cord-283427-fef9qsik	37	8	used	use	VBN
cord-283427-fef9qsik	37	9	as	as	IN
cord-283427-fef9qsik	37	10	experimental	experimental	JJ
cord-283427-fef9qsik	37	11	groups	group	NNS
cord-283427-fef9qsik	37	12	.	.	.
cord-283427-fef9qsik	38	1	One	one	CD
cord-283427-fef9qsik	38	2	is	be	VBZ
cord-283427-fef9qsik	38	3	a	a	DT
cord-283427-fef9qsik	38	4	killed	kill	VBN
cord-283427-fef9qsik	38	5	vaccine	vaccine	NN
cord-283427-fef9qsik	38	6	,	,	,
cord-283427-fef9qsik	38	7	a	a	DT
cord-283427-fef9qsik	38	8	porcine	porcine	JJ
cord-283427-fef9qsik	38	9	genital	genital	JJ
cord-283427-fef9qsik	38	10	respiratory	respiratory	JJ
cord-283427-fef9qsik	38	11	syndrome	syndrome	NN
cord-283427-fef9qsik	38	12	vaccine	vaccine	NN
cord-283427-fef9qsik	38	13	(	(	-LRB-
cord-283427-fef9qsik	38	14	Suishot	Suishot	NNP
cord-283427-fef9qsik	38	15	PRRS	PRRS	NNP
cord-283427-fef9qsik	38	16	,	,	,
cord-283427-fef9qsik	38	17	Choongang	Choongang	NNP
cord-283427-fef9qsik	38	18	vaccine	vaccine	NN
cord-283427-fef9qsik	38	19	,	,	,
cord-283427-fef9qsik	38	20	Korea	Korea	NNP
cord-283427-fef9qsik	38	21	)	)	-RRB-
cord-283427-fef9qsik	38	22	.	.	.
cord-283427-fef9qsik	39	1	The	the	DT
cord-283427-fef9qsik	39	2	other	other	JJ
cord-283427-fef9qsik	39	3	one	one	NN
cord-283427-fef9qsik	39	4	is	be	VBZ
cord-283427-fef9qsik	39	5	a	a	DT
cord-283427-fef9qsik	39	6	live	live	JJ
cord-283427-fef9qsik	39	7	vaccine	vaccine	NN
cord-283427-fef9qsik	39	8	,	,	,
cord-283427-fef9qsik	39	9	a	a	DT
cord-283427-fef9qsik	39	10	canine	canine	JJ
cord-283427-fef9qsik	39	11	parvovirus	parvovirus	NN
cord-283427-fef9qsik	39	12	vaccine	vaccine	NN
cord-283427-fef9qsik	39	13	(	(	-LRB-
cord-283427-fef9qsik	39	14	Zoetis	Zoetis	NNP
cord-283427-fef9qsik	39	15	Inc.	Inc.	NNP
cord-283427-fef9qsik	39	16	,	,	,
cord-283427-fef9qsik	39	17	USA	USA	NNP
cord-283427-fef9qsik	39	18	)	)	-RRB-
cord-283427-fef9qsik	39	19	.	.	.
cord-283427-fef9qsik	40	1	The	the	DT
cord-283427-fef9qsik	40	2	concentration	concentration	NN
cord-283427-fef9qsik	40	3	of	of	IN
cord-283427-fef9qsik	40	4	the	the	DT
cord-283427-fef9qsik	40	5	stock	stock	NN
cord-283427-fef9qsik	40	6	solution	solution	NN
cord-283427-fef9qsik	40	7	of	of	IN
cord-283427-fef9qsik	40	8	these	these	DT
cord-283427-fef9qsik	40	9	two	two	CD
cord-283427-fef9qsik	40	10	vaccines	vaccine	NNS
cord-283427-fef9qsik	40	11	is	be	VBZ
cord-283427-fef9qsik	40	12	0.5	0.5	CD
cord-283427-fef9qsik	40	13	×	×	CD
cord-283427-fef9qsik	40	14	10	10	CD
cord-283427-fef9qsik	40	15	7.0	7.0	CD
cord-283427-fef9qsik	40	16	TCID	TCID	NNP
cord-283427-fef9qsik	40	17	50	50	CD
cord-283427-fef9qsik	40	18	/ml	/ml	.
cord-283427-fef9qsik	40	19	.	.	.
cord-283427-fef9qsik	41	1	We	-PRON-	PRP
cord-283427-fef9qsik	41	2	set	set	VBD
cord-283427-fef9qsik	41	3	these	these	DT
cord-283427-fef9qsik	41	4	concentrations	concentration	NNS
cord-283427-fef9qsik	41	5	to	to	TO
cord-283427-fef9qsik	41	6	assess	assess	VB
cord-283427-fef9qsik	41	7	the	the	DT
cord-283427-fef9qsik	41	8	effect	effect	NN
cord-283427-fef9qsik	41	9	of	of	IN
cord-283427-fef9qsik	41	10	these	these	DT
cord-283427-fef9qsik	41	11	vaccines	vaccine	NNS
cord-283427-fef9qsik	41	12	on	on	IN
cord-283427-fef9qsik	41	13	the	the	DT
cord-283427-fef9qsik	41	14	BBB	BBB	NNP
cord-283427-fef9qsik	41	15	,	,	,
cord-283427-fef9qsik	41	16	depending	depend	VBG
cord-283427-fef9qsik	41	17	on	on	IN
cord-283427-fef9qsik	41	18	the	the	DT
cord-283427-fef9qsik	41	19	concentration	concentration	NN
cord-283427-fef9qsik	41	20	.	.	.
cord-283427-fef9qsik	42	1	Through	through	IN
cord-283427-fef9qsik	42	2	the	the	DT
cord-283427-fef9qsik	42	3	previous	previous	JJ
cord-283427-fef9qsik	42	4	studies	study	NNS
cord-283427-fef9qsik	42	5	we	-PRON-	PRP
cord-283427-fef9qsik	42	6	confirmed	confirm	VBD
cord-283427-fef9qsik	42	7	that	that	IN
cord-283427-fef9qsik	42	8	the	the	DT
cord-283427-fef9qsik	42	9	effective	effective	JJ
cord-283427-fef9qsik	42	10	BBB	BBB	NNP
cord-283427-fef9qsik	42	11	destroyed	destroy	VBD
cord-283427-fef9qsik	42	12	concentration	concentration	NN
cord-283427-fef9qsik	42	13	of	of	IN
cord-283427-fef9qsik	42	14	these	these	DT
cord-283427-fef9qsik	42	15	vaccines	vaccine	NNS
cord-283427-fef9qsik	42	16	was	be	VBD
cord-283427-fef9qsik	42	17	2-fold	2-fold	CD
cord-283427-fef9qsik	42	18	concentration	concentration	NN
cord-283427-fef9qsik	42	19	of	of	IN
cord-283427-fef9qsik	42	20	the	the	DT
cord-283427-fef9qsik	42	21	stock	stock	NN
cord-283427-fef9qsik	42	22	solutions	solution	NNS
cord-283427-fef9qsik	42	23	.	.	.
cord-283427-fef9qsik	43	1	Therefore	therefore	RB
cord-283427-fef9qsik	43	2	,	,	,
cord-283427-fef9qsik	43	3	the	the	DT
cord-283427-fef9qsik	43	4	experiment	experiment	NN
cord-283427-fef9qsik	43	5	was	be	VBD
cord-283427-fef9qsik	43	6	conducted	conduct	VBN
cord-283427-fef9qsik	43	7	under	under	IN
cord-283427-fef9qsik	43	8	three	three	CD
cord-283427-fef9qsik	43	9	conditions	condition	NNS
cord-283427-fef9qsik	43	10	:	:	:
cord-283427-fef9qsik	43	11	2-fold	2-fold	CD
cord-283427-fef9qsik	43	12	concentration	concentration	NN
cord-283427-fef9qsik	43	13	of	of	IN
cord-283427-fef9qsik	43	14	the	the	DT
cord-283427-fef9qsik	43	15	stock	stock	NN
cord-283427-fef9qsik	43	16	solution	solution	NN
cord-283427-fef9qsik	43	17	,	,	,
cord-283427-fef9qsik	43	18	reference	reference	NN
cord-283427-fef9qsik	43	19	concentration	concentration	NN
cord-283427-fef9qsik	43	20	of	of	IN
cord-283427-fef9qsik	43	21	the	the	DT
cord-283427-fef9qsik	43	22	stock	stock	NN
cord-283427-fef9qsik	43	23	solution	solution	NN
cord-283427-fef9qsik	43	24	and	and	CC
cord-283427-fef9qsik	43	25	10-fold	10-fold	JJ
cord-283427-fef9qsik	43	26	diluted	diluted	JJ
cord-283427-fef9qsik	43	27	concentration	concentration	NN
cord-283427-fef9qsik	43	28	of	of	IN
cord-283427-fef9qsik	43	29	the	the	DT
cord-283427-fef9qsik	43	30	stock	stock	NN
cord-283427-fef9qsik	43	31	solution	solution	NN
cord-283427-fef9qsik	43	32	.	.	.
cord-283427-fef9qsik	44	1	Including	include	VBG
cord-283427-fef9qsik	44	2	negative	negative	JJ
cord-283427-fef9qsik	44	3	control	control	NN
cord-283427-fef9qsik	44	4	and	and	CC
cord-283427-fef9qsik	44	5	positive	positive	JJ
cord-283427-fef9qsik	44	6	control	control	NN
cord-283427-fef9qsik	44	7	,	,	,
cord-283427-fef9qsik	44	8	the	the	DT
cord-283427-fef9qsik	44	9	groups	group	NNS
cord-283427-fef9qsik	44	10	were	be	VBD
cord-283427-fef9qsik	44	11	divided	divide	VBN
cord-283427-fef9qsik	44	12	8	8	CD
cord-283427-fef9qsik	44	13	groups	group	NNS
cord-283427-fef9qsik	44	14	according	accord	VBG
cord-283427-fef9qsik	44	15	to	to	IN
cord-283427-fef9qsik	44	16	vaccine	vaccine	NN
cord-283427-fef9qsik	44	17	types	type	NNS
cord-283427-fef9qsik	44	18	and	and	CC
cord-283427-fef9qsik	44	19	concentrations	concentration	NNS
cord-283427-fef9qsik	44	20	:	:	:
cord-283427-fef9qsik	44	21	group	group	NN
cord-283427-fef9qsik	44	22	1	1	CD
cord-283427-fef9qsik	44	23	,	,	,
cord-283427-fef9qsik	44	24	PBS	PBS	NNP
cord-283427-fef9qsik	44	25	/	/	SYM
cord-283427-fef9qsik	44	26	EB(n	eb(n	NN
cord-283427-fef9qsik	44	27	=	=	SYM
cord-283427-fef9qsik	44	28	2	2	CD
cord-283427-fef9qsik	44	29	)	)	-RRB-
cord-283427-fef9qsik	44	30	;	;	:
cord-283427-fef9qsik	44	31	group2	group2	NN
cord-283427-fef9qsik	44	32	,	,	,
cord-283427-fef9qsik	44	33	LPS	LPS	NNP
cord-283427-fef9qsik	44	34	/	/	SYM
cord-283427-fef9qsik	44	35	EB(n	eb(n	NN
cord-283427-fef9qsik	44	36	=	=	SYM
cord-283427-fef9qsik	44	37	2	2	CD
cord-283427-fef9qsik	44	38	)	)	-RRB-
cord-283427-fef9qsik	44	39	;	;	:
cord-283427-fef9qsik	44	40	group3	group3	VB
cord-283427-fef9qsik	44	41	,	,	,
cord-283427-fef9qsik	44	42	2-fold	2-fold	CD
cord-283427-fef9qsik	44	43	concentration	concentration	NN
cord-283427-fef9qsik	44	44	of	of	IN
cord-283427-fef9qsik	44	45	the	the	DT
cord-283427-fef9qsik	44	46	porcine	porcine	JJ
cord-283427-fef9qsik	44	47	vaccine	vaccine	NN
cord-283427-fef9qsik	44	48	/	/	SYM
cord-283427-fef9qsik	44	49	EB	EB	NNP
cord-283427-fef9qsik	44	50	(	(	-LRB-
cord-283427-fef9qsik	44	51	P1	P1	NNP
cord-283427-fef9qsik	44	52	,	,	,
cord-283427-fef9qsik	44	53	n	n	NN
cord-283427-fef9qsik	44	54	=	=	SYM
cord-283427-fef9qsik	44	55	5	5	CD
cord-283427-fef9qsik	44	56	)	)	-RRB-
cord-283427-fef9qsik	44	57	;	;	:
cord-283427-fef9qsik	44	58	group4	group4	NN
cord-283427-fef9qsik	44	59	,	,	,
cord-283427-fef9qsik	44	60	reference	reference	NN
cord-283427-fef9qsik	44	61	concentration	concentration	NN
cord-283427-fef9qsik	44	62	of	of	IN
cord-283427-fef9qsik	44	63	the	the	DT
cord-283427-fef9qsik	44	64	porcine	porcine	JJ
cord-283427-fef9qsik	44	65	vaccine	vaccine	NN
cord-283427-fef9qsik	44	66	/	/	SYM
cord-283427-fef9qsik	44	67	EB	EB	NNP
cord-283427-fef9qsik	44	68	(	(	-LRB-
cord-283427-fef9qsik	44	69	P2	P2	NNP
cord-283427-fef9qsik	44	70	,	,	,
cord-283427-fef9qsik	44	71	n	n	NN
cord-283427-fef9qsik	44	72	=	=	SYM
cord-283427-fef9qsik	44	73	5	5	CD
cord-283427-fef9qsik	44	74	)	)	-RRB-
cord-283427-fef9qsik	44	75	;	;	:
cord-283427-fef9qsik	44	76	group5	group5	NN
cord-283427-fef9qsik	44	77	,	,	,
cord-283427-fef9qsik	44	78	10-fold	10-fold	JJ
cord-283427-fef9qsik	44	79	diluted	diluted	JJ
cord-283427-fef9qsik	44	80	concentration	concentration	NN
cord-283427-fef9qsik	44	81	of	of	IN
cord-283427-fef9qsik	44	82	the	the	DT
cord-283427-fef9qsik	44	83	porcine	porcine	JJ
cord-283427-fef9qsik	44	84	vaccine	vaccine	NN
cord-283427-fef9qsik	44	85	/	/	SYM
cord-283427-fef9qsik	44	86	EB	EB	NNP
cord-283427-fef9qsik	44	87	(	(	-LRB-
cord-283427-fef9qsik	44	88	P3	P3	NNP
cord-283427-fef9qsik	44	89	,	,	,
cord-283427-fef9qsik	44	90	n	n	NN
cord-283427-fef9qsik	44	91	=	=	SYM
cord-283427-fef9qsik	44	92	5	5	CD
cord-283427-fef9qsik	44	93	)	)	-RRB-
cord-283427-fef9qsik	44	94	;	;	:
cord-283427-fef9qsik	44	95	group6	group6	NN
cord-283427-fef9qsik	44	96	,	,	,
cord-283427-fef9qsik	44	97	2-fold	2-fold	CD
cord-283427-fef9qsik	44	98	concentration	concentration	NN
cord-283427-fef9qsik	44	99	of	of	IN
cord-283427-fef9qsik	44	100	the	the	DT
cord-283427-fef9qsik	44	101	canine	canine	JJ
cord-283427-fef9qsik	44	102	vaccine	vaccine	NN
cord-283427-fef9qsik	44	103	/	/	SYM
cord-283427-fef9qsik	44	104	EB	EB	NNP
cord-283427-fef9qsik	44	105	(	(	-LRB-
cord-283427-fef9qsik	44	106	C1	C1	NNP
cord-283427-fef9qsik	44	107	,	,	,
cord-283427-fef9qsik	44	108	n	n	NN
cord-283427-fef9qsik	44	109	=	=	SYM
cord-283427-fef9qsik	44	110	5	5	CD
cord-283427-fef9qsik	44	111	)	)	-RRB-
cord-283427-fef9qsik	44	112	;	;	:
cord-283427-fef9qsik	44	113	group7	group7	JJ
cord-283427-fef9qsik	44	114	,	,	,
cord-283427-fef9qsik	44	115	reference	reference	NN
cord-283427-fef9qsik	44	116	concentration	concentration	NN
cord-283427-fef9qsik	44	117	of	of	IN
cord-283427-fef9qsik	44	118	the	the	DT
cord-283427-fef9qsik	44	119	canine	canine	JJ
cord-283427-fef9qsik	44	120	vaccine	vaccine	NN
cord-283427-fef9qsik	44	121	/	/	SYM
cord-283427-fef9qsik	44	122	EB	EB	NNP
cord-283427-fef9qsik	44	123	(	(	-LRB-
cord-283427-fef9qsik	44	124	C2	C2	NNP
cord-283427-fef9qsik	44	125	,	,	,
cord-283427-fef9qsik	44	126	n	n	NN
cord-283427-fef9qsik	44	127	=	=	SYM
cord-283427-fef9qsik	44	128	5	5	CD
cord-283427-fef9qsik	44	129	)	)	-RRB-
cord-283427-fef9qsik	44	130	;	;	:
cord-283427-fef9qsik	44	131	group8	group8	NN
cord-283427-fef9qsik	44	132	,	,	,
cord-283427-fef9qsik	44	133	10fold	10fold	JJ
cord-283427-fef9qsik	44	134	diluted	diluted	JJ
cord-283427-fef9qsik	44	135	concentration	concentration	NN
cord-283427-fef9qsik	44	136	of	of	IN
cord-283427-fef9qsik	44	137	the	the	DT
cord-283427-fef9qsik	44	138	canine	canine	JJ
cord-283427-fef9qsik	44	139	vaccine	vaccine	NN
cord-283427-fef9qsik	44	140	/	/	SYM
cord-283427-fef9qsik	44	141	EB	EB	NNP
cord-283427-fef9qsik	44	142	(	(	-LRB-
cord-283427-fef9qsik	44	143	C3	C3	NNP
cord-283427-fef9qsik	44	144	,	,	,
cord-283427-fef9qsik	44	145	n	n	NN
cord-283427-fef9qsik	44	146	=	=	SYM
cord-283427-fef9qsik	44	147	5	5	CD
cord-283427-fef9qsik	44	148	)	)	-RRB-
cord-283427-fef9qsik	44	149	.	.	.
cord-283427-fef9qsik	45	1	We	-PRON-	PRP
cord-283427-fef9qsik	45	2	performed	perform	VBD
cord-283427-fef9qsik	45	3	the	the	DT
cord-283427-fef9qsik	45	4	EB	EB	NNP
cord-283427-fef9qsik	45	5	assay	assay	NN
cord-283427-fef9qsik	45	6	according	accord	VBG
cord-283427-fef9qsik	45	7	to	to	IN
cord-283427-fef9qsik	45	8	the	the	DT
cord-283427-fef9qsik	45	9	method	method	NN
cord-283427-fef9qsik	45	10	of	of	IN
cord-283427-fef9qsik	45	11	Baek	Baek	NNP
cord-283427-fef9qsik	45	12	et	et	NNP
cord-283427-fef9qsik	45	13	al	al	NNP
cord-283427-fef9qsik	45	14	.	.	.
cord-283427-fef9qsik	46	1	[	[	-LRB-
cord-283427-fef9qsik	46	2	1	1	CD
cord-283427-fef9qsik	46	3	]	]	-RRB-
cord-283427-fef9qsik	46	4	,	,	,
cord-283427-fef9qsik	46	5	used	use	VBN
cord-283427-fef9qsik	46	6	in	in	IN
cord-283427-fef9qsik	46	7	previous	previous	JJ
cord-283427-fef9qsik	46	8	studies	study	NNS
cord-283427-fef9qsik	46	9	.	.	.
cord-283427-fef9qsik	47	1	For	for	IN
cord-283427-fef9qsik	47	2	treatment	treatment	NN
cord-283427-fef9qsik	47	3	,	,	,
cord-283427-fef9qsik	47	4	PBS	PBS	NNP
cord-283427-fef9qsik	47	5	,	,	,
cord-283427-fef9qsik	47	6	LPS	LPS	NNP
cord-283427-fef9qsik	47	7	and	and	CC
cord-283427-fef9qsik	47	8	the	the	DT
cord-283427-fef9qsik	47	9	vaccines	vaccine	NNS
cord-283427-fef9qsik	47	10	were	be	VBD
cord-283427-fef9qsik	47	11	intraperitoneally	intraperitoneally	RB
cord-283427-fef9qsik	47	12	(	(	-LRB-
cord-283427-fef9qsik	47	13	i.p	i.p	NNP
cord-283427-fef9qsik	47	14	)	)	-RRB-
cord-283427-fef9qsik	47	15	injected	inject	VBD
cord-283427-fef9qsik	47	16	into	into	IN
cord-283427-fef9qsik	47	17	each	each	DT
cord-283427-fef9qsik	47	18	mouse	mouse	NN
cord-283427-fef9qsik	47	19	(	(	-LRB-
cord-283427-fef9qsik	47	20	1.0	1.0	CD
cord-283427-fef9qsik	47	21	mg/4	mg/4	CD
cord-283427-fef9qsik	48	1	mL/	mL/	NNP
cord-283427-fef9qsik	48	2	kg	kg	NN
cord-283427-fef9qsik	48	3	body	body	NN
cord-283427-fef9qsik	48	4	weight	weight	NN
cord-283427-fef9qsik	48	5	)	)	-RRB-
cord-283427-fef9qsik	48	6	.	.	.
cord-283427-fef9qsik	49	1	At	at	IN
cord-283427-fef9qsik	49	2	1	1	CD
cord-283427-fef9qsik	49	3	h	h	NN
cord-283427-fef9qsik	49	4	post	post	NN
cord-283427-fef9qsik	49	5	-	-	NN
cord-283427-fef9qsik	49	6	injection	injection	NN
cord-283427-fef9qsik	49	7	(	(	-LRB-
cord-283427-fef9qsik	49	8	PI	PI	NNP
cord-283427-fef9qsik	49	9	)	)	-RRB-
cord-283427-fef9qsik	49	10	of	of	IN
cord-283427-fef9qsik	49	11	PBS	PBS	NNP
cord-283427-fef9qsik	49	12	/	/	SYM
cord-283427-fef9qsik	49	13	LPS/	LPS/	NNP
cord-283427-fef9qsik	49	14	Vaccines	Vaccines	NNPS
cord-283427-fef9qsik	49	15	,	,	,
cord-283427-fef9qsik	49	16	EB	EB	NNP
cord-283427-fef9qsik	49	17	dye	dye	NN
cord-283427-fef9qsik	49	18	(	(	-LRB-
cord-283427-fef9qsik	49	19	2	2	CD
cord-283427-fef9qsik	49	20	%	%	NN
cord-283427-fef9qsik	49	21	w	w	NN
cord-283427-fef9qsik	49	22	/	/	SYM
cord-283427-fef9qsik	49	23	v	v	NN
cord-283427-fef9qsik	49	24	in	in	IN
cord-283427-fef9qsik	49	25	PBS	PBS	NNP
cord-283427-fef9qsik	49	26	,	,	,
cord-283427-fef9qsik	49	27	4	4	CD
cord-283427-fef9qsik	49	28	mL	ml	NN
cord-283427-fef9qsik	49	29	/	/	SYM
cord-283427-fef9qsik	49	30	kg	kg	NNS
cord-283427-fef9qsik	49	31	,	,	,
cord-283427-fef9qsik	49	32	E2129	E2129	NNP
cord-283427-fef9qsik	49	33	;	;	:
cord-283427-fef9qsik	49	34	Sigma	Sigma	NNP
cord-283427-fef9qsik	49	35	)	)	-RRB-
cord-283427-fef9qsik	49	36	was	be	VBD
cord-283427-fef9qsik	49	37	i.p	i.p	NNP
cord-283427-fef9qsik	49	38	injected	inject	VBD
cord-283427-fef9qsik	49	39	into	into	IN
cord-283427-fef9qsik	49	40	each	each	DT
cord-283427-fef9qsik	49	41	mouse	mouse	NN
cord-283427-fef9qsik	49	42	.	.	.
cord-283427-fef9qsik	50	1	All	all	DT
cord-283427-fef9qsik	50	2	mice	mouse	NNS
cord-283427-fef9qsik	50	3	were	be	VBD
cord-283427-fef9qsik	50	4	sacrificed	sacrifice	VBN
cord-283427-fef9qsik	50	5	after	after	IN
cord-283427-fef9qsik	50	6	3	3	CD
cord-283427-fef9qsik	50	7	h	h	NN
cord-283427-fef9qsik	50	8	of	of	IN
cord-283427-fef9qsik	50	9	EB	EB	NNP
cord-283427-fef9qsik	50	10	exposure	exposure	NN
cord-283427-fef9qsik	50	11	(	(	-LRB-
cord-283427-fef9qsik	50	12	4	4	CD
cord-283427-fef9qsik	50	13	h	h	NN
cord-283427-fef9qsik	50	14	PI	pi	NN
cord-283427-fef9qsik	50	15	)	)	-RRB-
cord-283427-fef9qsik	50	16	.	.	.
cord-283427-fef9qsik	51	1	After	after	IN
cord-283427-fef9qsik	51	2	sacrifice	sacrifice	NN
cord-283427-fef9qsik	51	3	,	,	,
cord-283427-fef9qsik	51	4	blood	blood	NN
cord-283427-fef9qsik	51	5	was	be	VBD
cord-283427-fef9qsik	51	6	collected	collect	VBN
cord-283427-fef9qsik	51	7	and	and	CC
cord-283427-fef9qsik	51	8	serum	serum	NN
cord-283427-fef9qsik	51	9	was	be	VBD
cord-283427-fef9qsik	51	10	separated	separate	VBN
cord-283427-fef9qsik	51	11	by	by	IN
cord-283427-fef9qsik	51	12	using	use	VBG
cord-283427-fef9qsik	51	13	centrifugation	centrifugation	NN
cord-283427-fef9qsik	51	14	.	.	.
cord-283427-fef9qsik	52	1	The	the	DT
cord-283427-fef9qsik	52	2	brain	brain	NN
cord-283427-fef9qsik	52	3	was	be	VBD
cord-283427-fef9qsik	52	4	promptly	promptly	RB
cord-283427-fef9qsik	52	5	removed	remove	VBN
cord-283427-fef9qsik	52	6	after	after	IN
cord-283427-fef9qsik	52	7	the	the	DT
cord-283427-fef9qsik	52	8	mouse	mouse	NN
cord-283427-fef9qsik	52	9	had	have	VBD
cord-283427-fef9qsik	52	10	been	be	VBN
cord-283427-fef9qsik	52	11	perfused	perfuse	VBN
cord-283427-fef9qsik	52	12	with	with	IN
cord-283427-fef9qsik	52	13	heparinized	heparinized	JJ
cord-283427-fef9qsik	52	14	PBS	PBS	NNP
cord-283427-fef9qsik	52	15	(	(	-LRB-
cord-283427-fef9qsik	52	16	0.1	0.1	CD
cord-283427-fef9qsik	52	17	mg	mg	NNP
cord-283427-fef9qsik	52	18	/	/	SYM
cord-283427-fef9qsik	52	19	L	L	NNP
cord-283427-fef9qsik	52	20	)	)	-RRB-
cord-283427-fef9qsik	52	21	.	.	.
cord-283427-fef9qsik	53	1	Serum	serum	NN
cord-283427-fef9qsik	53	2	and	and	CC
cord-283427-fef9qsik	53	3	homogenized	homogenized	JJ
cord-283427-fef9qsik	53	4	brain	brain	NN
cord-283427-fef9qsik	53	5	hemisphere	hemisphere	NN
cord-283427-fef9qsik	53	6	of	of	IN
cord-283427-fef9qsik	53	7	each	each	DT
cord-283427-fef9qsik	53	8	mouse	mouse	NN
cord-283427-fef9qsik	53	9	were	be	VBD
cord-283427-fef9qsik	53	10	dissolved	dissolve	VBN
cord-283427-fef9qsik	53	11	in	in	IN
cord-283427-fef9qsik	53	12	a	a	DT
cord-283427-fef9qsik	53	13	50	50	CD
cord-283427-fef9qsik	53	14	%	%	NN
cord-283427-fef9qsik	53	15	(	(	-LRB-
cord-283427-fef9qsik	53	16	w	w	NN
cord-283427-fef9qsik	53	17	/	/	SYM
cord-283427-fef9qsik	53	18	v	v	NN
cord-283427-fef9qsik	53	19	)	)	-RRB-
cord-283427-fef9qsik	53	20	trichloroacetic	trichloroacetic	JJ
cord-283427-fef9qsik	53	21	acid	acid	NN
cord-283427-fef9qsik	53	22	in	in	IN
cord-283427-fef9qsik	53	23	PBS	PBS	NNP
cord-283427-fef9qsik	53	24	solution	solution	NN
cord-283427-fef9qsik	53	25	to	to	TO
cord-283427-fef9qsik	53	26	eliminate	eliminate	VB
cord-283427-fef9qsik	53	27	proteins	protein	NNS
cord-283427-fef9qsik	53	28	and	and	CC
cord-283427-fef9qsik	53	29	then	then	RB
cord-283427-fef9qsik	53	30	subjected	subject	VBN
cord-283427-fef9qsik	53	31	to	to	IN
cord-283427-fef9qsik	53	32	centrifugation	centrifugation	NN
cord-283427-fef9qsik	53	33	at	at	IN
cord-283427-fef9qsik	53	34	5000×g	5000×g	CD
cord-283427-fef9qsik	53	35	for	for	IN
cord-283427-fef9qsik	53	36	20	20	CD
cord-283427-fef9qsik	53	37	min	min	NN
cord-283427-fef9qsik	53	38	.	.	.
cord-283427-fef9qsik	54	1	Supernatant	supernatant	JJ
cord-283427-fef9qsik	54	2	of	of	IN
cord-283427-fef9qsik	54	3	each	each	DT
cord-283427-fef9qsik	54	4	sample	sample	NN
cord-283427-fef9qsik	54	5	was	be	VBD
cord-283427-fef9qsik	54	6	diluted	dilute	VBN
cord-283427-fef9qsik	54	7	1:3	1:3	CD
cord-283427-fef9qsik	54	8	with	with	IN
cord-283427-fef9qsik	54	9	absolute	absolute	JJ
cord-283427-fef9qsik	54	10	ethanol	ethanol	NN
cord-283427-fef9qsik	54	11	.	.	.
cord-283427-fef9qsik	55	1	A	a	DT
cord-283427-fef9qsik	55	2	spectrophotometer	spectrophotometer	NN
cord-283427-fef9qsik	55	3	(	(	-LRB-
cord-283427-fef9qsik	55	4	Infinite	infinite	JJ
cord-283427-fef9qsik	55	5	F200	f200	NN
cord-283427-fef9qsik	55	6	;	;	:
cord-283427-fef9qsik	55	7	Tecan	Tecan	NNP
cord-283427-fef9qsik	55	8	,	,	,
cord-283427-fef9qsik	55	9	Switzerland	Switzerland	NNP
cord-283427-fef9qsik	55	10	)	)	-RRB-
cord-283427-fef9qsik	55	11	was	be	VBD
cord-283427-fef9qsik	55	12	used	use	VBN
cord-283427-fef9qsik	55	13	to	to	TO
cord-283427-fef9qsik	55	14	determine	determine	VB
cord-283427-fef9qsik	55	15	the	the	DT
cord-283427-fef9qsik	55	16	EB	EB	NNP
cord-283427-fef9qsik	55	17	concentrations	concentration	NNS
cord-283427-fef9qsik	55	18	in	in	IN
cord-283427-fef9qsik	55	19	the	the	DT
cord-283427-fef9qsik	55	20	serum	serum	NN
cord-283427-fef9qsik	55	21	and	and	CC
cord-283427-fef9qsik	55	22	brain	brain	NN
cord-283427-fef9qsik	55	23	hemisphere	hemisphere	NN
cord-283427-fef9qsik	55	24	samples	sample	NNS
cord-283427-fef9qsik	55	25	.	.	.
cord-283427-fef9qsik	56	1	The	the	DT
cord-283427-fef9qsik	56	2	fluorescence	fluorescence	NN
cord-283427-fef9qsik	56	3	intensity	intensity	NN
cord-283427-fef9qsik	56	4	was	be	VBD
cord-283427-fef9qsik	56	5	measured	measure	VBN
cord-283427-fef9qsik	56	6	at	at	IN
cord-283427-fef9qsik	56	7	620λ	620λ	NNP
cord-283427-fef9qsik	56	8	ex	ex	NNP
cord-283427-fef9qsik	56	9	and	and	CC
cord-283427-fef9qsik	56	10	680	680	CD
cord-283427-fef9qsik	56	11	em	-PRON-	PRP
cord-283427-fef9qsik	56	12	,	,	,
cord-283427-fef9qsik	56	13	and	and	CC
cord-283427-fef9qsik	56	14	the	the	DT
cord-283427-fef9qsik	56	15	EB	EB	NNP
cord-283427-fef9qsik	56	16	concentration	concentration	NN
cord-283427-fef9qsik	56	17	of	of	IN
cord-283427-fef9qsik	56	18	each	each	DT
cord-283427-fef9qsik	56	19	sample	sample	NN
cord-283427-fef9qsik	56	20	was	be	VBD
cord-283427-fef9qsik	56	21	calculated	calculate	VBN
cord-283427-fef9qsik	56	22	according	accord	VBG
cord-283427-fef9qsik	56	23	to	to	IN
cord-283427-fef9qsik	56	24	a	a	DT
cord-283427-fef9qsik	56	25	standard	standard	JJ
cord-283427-fef9qsik	56	26	curve	curve	NN
cord-283427-fef9qsik	56	27	that	that	WDT
cord-283427-fef9qsik	56	28	had	have	VBD
cord-283427-fef9qsik	56	29	been	be	VBN
cord-283427-fef9qsik	56	30	ordered	order	VBN
cord-283427-fef9qsik	56	31	to	to	TO
cord-283427-fef9qsik	56	32	determine	determine	VB
cord-283427-fef9qsik	56	33	the	the	DT
cord-283427-fef9qsik	56	34	penetration	penetration	NN
cord-283427-fef9qsik	56	35	rate	rate	NN
cord-283427-fef9qsik	56	36	for	for	IN
cord-283427-fef9qsik	56	37	EB	EB	NNP
cord-283427-fef9qsik	56	38	in	in	IN
cord-283427-fef9qsik	56	39	brain	brain	NN
cord-283427-fef9qsik	56	40	to	to	IN
cord-283427-fef9qsik	56	41	EB	EB	NNP
cord-283427-fef9qsik	56	42	in	in	IN
cord-283427-fef9qsik	56	43	blood	blood	NN
cord-283427-fef9qsik	56	44	was	be	VBD
cord-283427-fef9qsik	56	45	calculated	calculate	VBN
cord-283427-fef9qsik	56	46	.	.	.
cord-283427-fef9qsik	57	1	Following	follow	VBG
cord-283427-fef9qsik	57	2	the	the	DT
cord-283427-fef9qsik	57	3	EB	EB	NNP
cord-283427-fef9qsik	57	4	assay	assay	NN
cord-283427-fef9qsik	57	5	,	,	,
cord-283427-fef9qsik	57	6	the	the	DT
cord-283427-fef9qsik	57	7	safety	safety	NN
cord-283427-fef9qsik	57	8	of	of	IN
cord-283427-fef9qsik	57	9	the	the	DT
cord-283427-fef9qsik	57	10	vaccine	vaccine	NN
cord-283427-fef9qsik	57	11	was	be	VBD
cord-283427-fef9qsik	57	12	assessed	assess	VBN
cord-283427-fef9qsik	57	13	by	by	IN
cord-283427-fef9qsik	57	14	mRNA	mrna	NN
cord-283427-fef9qsik	57	15	expression	expression	NN
cord-283427-fef9qsik	57	16	of	of	IN
cord-283427-fef9qsik	57	17	the	the	DT
cord-283427-fef9qsik	57	18	molecules	molecule	NNS
cord-283427-fef9qsik	57	19	forming	form	VBG
cord-283427-fef9qsik	57	20	the	the	DT
cord-283427-fef9qsik	57	21	tight	tight	JJ
cord-283427-fef9qsik	57	22	junction	junction	NN
cord-283427-fef9qsik	57	23	of	of	IN
cord-283427-fef9qsik	57	24	the	the	DT
cord-283427-fef9qsik	57	25	brain	brain	NN
cord-283427-fef9qsik	57	26	.	.	.
cord-283427-fef9qsik	58	1	Groups	group	NNS
cord-283427-fef9qsik	58	2	and	and	CC
cord-283427-fef9qsik	58	3	experimental	experimental	JJ
cord-283427-fef9qsik	58	4	conditions	condition	NNS
cord-283427-fef9qsik	58	5	were	be	VBD
cord-283427-fef9qsik	58	6	used	use	VBN
cord-283427-fef9qsik	58	7	same	same	JJ
cord-283427-fef9qsik	58	8	as	as	IN
cord-283427-fef9qsik	58	9	EB	EB	NNP
cord-283427-fef9qsik	58	10	assay	assay	NN
cord-283427-fef9qsik	58	11	.	.	.
cord-283427-fef9qsik	59	1	The	the	DT
cord-283427-fef9qsik	59	2	LPS	LPS	NNP
cord-283427-fef9qsik	59	3	solution	solution	NN
cord-283427-fef9qsik	59	4	was	be	VBD
cord-283427-fef9qsik	59	5	i.p	i.p	NNP
cord-283427-fef9qsik	59	6	.	.	NNP
cord-283427-fef9qsik	59	7	injected	inject	VBN
cord-283427-fef9qsik	59	8	into	into	IN
cord-283427-fef9qsik	59	9	all	all	DT
cord-283427-fef9qsik	59	10	mice	mouse	NNS
cord-283427-fef9qsik	59	11	and	and	CC
cord-283427-fef9qsik	59	12	sacrificed	sacrifice	VBD
cord-283427-fef9qsik	59	13	at	at	IN
cord-283427-fef9qsik	59	14	the	the	DT
cord-283427-fef9qsik	59	15	4	4	CD
cord-283427-fef9qsik	59	16	h	h	NN
cord-283427-fef9qsik	59	17	PI	pi	NN
cord-283427-fef9qsik	59	18	time	time	NN
cord-283427-fef9qsik	59	19	.	.	.
cord-283427-fef9qsik	60	1	After	after	IN
cord-283427-fef9qsik	60	2	sacrifice	sacrifice	NN
cord-283427-fef9qsik	60	3	,	,	,
cord-283427-fef9qsik	60	4	the	the	DT
cord-283427-fef9qsik	60	5	brains	brain	NNS
cord-283427-fef9qsik	60	6	were	be	VBD
cord-283427-fef9qsik	60	7	removed	remove	VBN
cord-283427-fef9qsik	60	8	from	from	IN
cord-283427-fef9qsik	60	9	each	each	DT
cord-283427-fef9qsik	60	10	mouse	mouse	NN
cord-283427-fef9qsik	60	11	and	and	CC
cord-283427-fef9qsik	60	12	were	be	VBD
cord-283427-fef9qsik	60	13	prepared	prepare	VBN
cord-283427-fef9qsik	60	14	for	for	IN
cord-283427-fef9qsik	60	15	next	next	JJ
cord-283427-fef9qsik	60	16	steps	step	NNS
cord-283427-fef9qsik	60	17	.	.	.
cord-283427-fef9qsik	61	1	RNA	RNA	NNP
cord-283427-fef9qsik	61	2	was	be	VBD
cord-283427-fef9qsik	61	3	extracted	extract	VBN
cord-283427-fef9qsik	61	4	by	by	IN
cord-283427-fef9qsik	61	5	using	use	VBG
cord-283427-fef9qsik	61	6	Trizol	Trizol	NNP
cord-283427-fef9qsik	61	7	reagent	reagent	NN
cord-283427-fef9qsik	61	8	(	(	-LRB-
cord-283427-fef9qsik	61	9	Ambion	Ambion	NNP
cord-283427-fef9qsik	61	10	;	;	:
cord-283427-fef9qsik	61	11	Life	Life	NNP
cord-283427-fef9qsik	61	12	Technologies	Technologies	NNPS
cord-283427-fef9qsik	61	13	,	,	,
cord-283427-fef9qsik	61	14	USA	USA	NNP
cord-283427-fef9qsik	61	15	)	)	-RRB-
cord-283427-fef9qsik	61	16	according	accord	VBG
cord-283427-fef9qsik	61	17	to	to	IN
cord-283427-fef9qsik	61	18	the	the	DT
cord-283427-fef9qsik	61	19	manufacture	manufacture	NN
cord-283427-fef9qsik	61	20	's	's	POS
cord-283427-fef9qsik	61	21	instruction	instruction	NN
cord-283427-fef9qsik	61	22	.	.	.
cord-283427-fef9qsik	62	1	For	for	IN
cord-283427-fef9qsik	62	2	RNA	RNA	NNP
cord-283427-fef9qsik	62	3	extraction	extraction	NN
cord-283427-fef9qsik	62	4	,	,	,
cord-283427-fef9qsik	62	5	the	the	DT
cord-283427-fef9qsik	62	6	homogenized	homogenized	JJ
cord-283427-fef9qsik	62	7	brain	brain	NN
cord-283427-fef9qsik	62	8	tissue	tissue	NN
cord-283427-fef9qsik	62	9	was	be	VBD
cord-283427-fef9qsik	62	10	incubated	incubate	VBN
cord-283427-fef9qsik	62	11	in	in	IN
cord-283427-fef9qsik	62	12	Trizol	Trizol	NNP
cord-283427-fef9qsik	62	13	and	and	CC
cord-283427-fef9qsik	62	14	chloroform	chloroform	NN
cord-283427-fef9qsik	62	15	reagent	reagent	NN
cord-283427-fef9qsik	62	16	and	and	CC
cord-283427-fef9qsik	62	17	then	then	RB
cord-283427-fef9qsik	62	18	subjected	subject	VBN
cord-283427-fef9qsik	62	19	to	to	IN
cord-283427-fef9qsik	62	20	centrifugation	centrifugation	NN
cord-283427-fef9qsik	62	21	.	.	.
cord-283427-fef9qsik	63	1	The	the	DT
cord-283427-fef9qsik	63	2	aqueous	aqueous	JJ
cord-283427-fef9qsik	63	3	phase	phase	NN
cord-283427-fef9qsik	63	4	was	be	VBD
cord-283427-fef9qsik	63	5	removed	remove	VBN
cord-283427-fef9qsik	63	6	and	and	CC
cord-283427-fef9qsik	63	7	incubated	incubate	VBN
cord-283427-fef9qsik	63	8	with	with	IN
cord-283427-fef9qsik	63	9	100	100	CD
cord-283427-fef9qsik	63	10	%	%	NN
cord-283427-fef9qsik	63	11	isopropanol	isopropanol	NN
cord-283427-fef9qsik	63	12	.	.	.
cord-283427-fef9qsik	64	1	After	after	IN
cord-283427-fef9qsik	64	2	centrifugation	centrifugation	NN
cord-283427-fef9qsik	64	3	,	,	,
cord-283427-fef9qsik	64	4	the	the	DT
cord-283427-fef9qsik	64	5	obtained	obtain	VBN
cord-283427-fef9qsik	64	6	RNA	RNA	NNP
cord-283427-fef9qsik	64	7	pellet	pellet	NN
cord-283427-fef9qsik	64	8	was	be	VBD
cord-283427-fef9qsik	64	9	washed	wash	VBN
cord-283427-fef9qsik	64	10	with	with	IN
cord-283427-fef9qsik	64	11	75	75	CD
cord-283427-fef9qsik	64	12	%	%	NN
cord-283427-fef9qsik	64	13	ice	ice	NN
cord-283427-fef9qsik	64	14	-	-	HYPH
cord-283427-fef9qsik	64	15	cold	cold	JJ
cord-283427-fef9qsik	64	16	ethanol	ethanol	NN
cord-283427-fef9qsik	64	17	and	and	CC
cord-283427-fef9qsik	64	18	then	then	RB
cord-283427-fef9qsik	64	19	dissolved	dissolve	VBD
cord-283427-fef9qsik	64	20	in	in	IN
cord-283427-fef9qsik	64	21	RNase	rnase	NN
cord-283427-fef9qsik	64	22	-	-	HYPH
cord-283427-fef9qsik	64	23	free	free	JJ
cord-283427-fef9qsik	64	24	water	water	NN
cord-283427-fef9qsik	64	25	.	.	.
cord-283427-fef9qsik	65	1	The	the	DT
cord-283427-fef9qsik	65	2	obtained	obtain	VBN
cord-283427-fef9qsik	65	3	RNA	RNA	NNP
cord-283427-fef9qsik	65	4	extract	extract	NN
cord-283427-fef9qsik	65	5	solution	solution	NN
cord-283427-fef9qsik	65	6	was	be	VBD
cord-283427-fef9qsik	65	7	stored	store	VBN
cord-283427-fef9qsik	65	8	at	at	IN
cord-283427-fef9qsik	65	9	−	−	CD
cord-283427-fef9qsik	65	10	70	70	CD
cord-283427-fef9qsik	65	11	°	°	NN
cord-283427-fef9qsik	65	12	C	c	NN
cord-283427-fef9qsik	65	13	after	after	IN
cord-283427-fef9qsik	65	14	undergoing	undergo	VBG
cord-283427-fef9qsik	65	15	60	60	CD
cord-283427-fef9qsik	65	16	°	°	NN
cord-283427-fef9qsik	65	17	C	c	NN
cord-283427-fef9qsik	65	18	heat	heat	NN
cord-283427-fef9qsik	65	19	incubation	incubation	NN
cord-283427-fef9qsik	65	20	.	.	.
cord-283427-fef9qsik	66	1	Quantification	quantification	NN
cord-283427-fef9qsik	66	2	of	of	IN
cord-283427-fef9qsik	66	3	mRNA	mRNA	NNP
cord-283427-fef9qsik	66	4	expression	expression	NN
cord-283427-fef9qsik	66	5	of	of	IN
cord-283427-fef9qsik	66	6	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	66	7	and	and	CC
cord-283427-fef9qsik	66	8	occluding	occlude	VBG
cord-283427-fef9qsik	66	9	in	in	IN
cord-283427-fef9qsik	66	10	the	the	DT
cord-283427-fef9qsik	66	11	brain	brain	NN
cord-283427-fef9qsik	67	1	Quantitative	quantitative	JJ
cord-283427-fef9qsik	67	2	real	real	JJ
cord-283427-fef9qsik	67	3	-	-	HYPH
cord-283427-fef9qsik	67	4	time	time	NN
cord-283427-fef9qsik	67	5	polymerase	polymerase	NN
cord-283427-fef9qsik	67	6	chain	chain	NN
cord-283427-fef9qsik	67	7	reaction	reaction	NN
cord-283427-fef9qsik	67	8	(	(	-LRB-
cord-283427-fef9qsik	67	9	qPCR	qPCR	NNP
cord-283427-fef9qsik	67	10	)	)	-RRB-
cord-283427-fef9qsik	67	11	was	be	VBD
cord-283427-fef9qsik	67	12	performed	perform	VBN
cord-283427-fef9qsik	67	13	with	with	IN
cord-283427-fef9qsik	67	14	SYBR	SYBR	NNP
cord-283427-fef9qsik	67	15	Green	Green	NNP
cord-283427-fef9qsik	67	16	dye	dye	NN
cord-283427-fef9qsik	67	17	by	by	IN
cord-283427-fef9qsik	67	18	using	use	VBG
cord-283427-fef9qsik	67	19	a	a	DT
cord-283427-fef9qsik	67	20	Step	Step	NNP
cord-283427-fef9qsik	67	21	One	One	NNP
cord-283427-fef9qsik	67	22	Plus	Plus	NNP
cord-283427-fef9qsik	67	23	Real	real	JJ
cord-283427-fef9qsik	67	24	-	-	HYPH
cord-283427-fef9qsik	67	25	time	time	NN
cord-283427-fef9qsik	67	26	PCR	pcr	NN
cord-283427-fef9qsik	67	27	system	system	NN
cord-283427-fef9qsik	67	28	(	(	-LRB-
cord-283427-fef9qsik	67	29	Life	Life	NNP
cord-283427-fef9qsik	67	30	Technologies	Technologies	NNPS
cord-283427-fef9qsik	67	31	)	)	-RRB-
cord-283427-fef9qsik	67	32	.	.	.
cord-283427-fef9qsik	68	1	For	for	IN
cord-283427-fef9qsik	68	2	relative	relative	JJ
cord-283427-fef9qsik	68	3	quantitation	quantitation	NN
cord-283427-fef9qsik	68	4	of	of	IN
cord-283427-fef9qsik	68	5	gene	gene	NN
cord-283427-fef9qsik	68	6	expression	expression	NN
cord-283427-fef9qsik	68	7	,	,	,
cord-283427-fef9qsik	68	8	we	-PRON-	PRP
cord-283427-fef9qsik	68	9	used	use	VBD
cord-283427-fef9qsik	68	10	the	the	DT
cord-283427-fef9qsik	68	11	comparative	comparative	JJ
cord-283427-fef9qsik	68	12	cycle	cycle	NN
cord-283427-fef9qsik	68	13	threshold	threshold	NN
cord-283427-fef9qsik	68	14	(	(	-LRB-
cord-283427-fef9qsik	68	15	Ct	Ct	NNP
cord-283427-fef9qsik	68	16	)	)	-RRB-
cord-283427-fef9qsik	68	17	method	method	NN
cord-283427-fef9qsik	68	18	(	(	-LRB-
cord-283427-fef9qsik	68	19	2	2	CD
cord-283427-fef9qsik	68	20	-	-	HYPH
cord-283427-fef9qsik	68	21	△	△	NNP
cord-283427-fef9qsik	68	22	△	△	NNP
cord-283427-fef9qsik	68	23	Ct	Ct	NNP
cord-283427-fef9qsik	68	24	)	)	-RRB-
cord-283427-fef9qsik	68	25	.	.	.
cord-283427-fef9qsik	69	1	Results	result	NNS
cord-283427-fef9qsik	69	2	were	be	VBD
cord-283427-fef9qsik	69	3	normalized	normalize	VBN
cord-283427-fef9qsik	69	4	to	to	IN
cord-283427-fef9qsik	69	5	that	that	DT
cord-283427-fef9qsik	69	6	of	of	IN
cord-283427-fef9qsik	69	7	the	the	DT
cord-283427-fef9qsik	69	8	housekeeping	housekeeping	NN
cord-283427-fef9qsik	69	9	/	/	SYM
cord-283427-fef9qsik	69	10	control	control	NN
cord-283427-fef9qsik	69	11	gene	gene	NN
cord-283427-fef9qsik	69	12	glyceraldehyde	glyceraldehyde	NN
cord-283427-fef9qsik	69	13	3-phosphate	3-phosphate	CD
cord-283427-fef9qsik	69	14	dehydrogenase	dehydrogenase	NN
cord-283427-fef9qsik	69	15	(	(	-LRB-
cord-283427-fef9qsik	69	16	GAPDH	GAPDH	NNP
cord-283427-fef9qsik	69	17	)	)	-RRB-
cord-283427-fef9qsik	69	18	.	.	.
cord-283427-fef9qsik	70	1	The	the	DT
cord-283427-fef9qsik	70	2	primer	primer	NN
cord-283427-fef9qsik	70	3	sequences	sequence	NNS
cord-283427-fef9qsik	70	4	for	for	IN
cord-283427-fef9qsik	70	5	zonula	zonula	NN
cord-283427-fef9qsik	70	6	occludens-1	occludens-1	NNP
cord-283427-fef9qsik	70	7	(	(	-LRB-
cord-283427-fef9qsik	70	8	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	70	9	)	)	-RRB-
cord-283427-fef9qsik	70	10	and	and	CC
cord-283427-fef9qsik	70	11	occludin	occludin	NNP
cord-283427-fef9qsik	70	12	have	have	VBP
cord-283427-fef9qsik	70	13	been	be	VBN
cord-283427-fef9qsik	70	14	used	use	VBN
cord-283427-fef9qsik	70	15	in	in	IN
cord-283427-fef9qsik	70	16	our	-PRON-	PRP$
cord-283427-fef9qsik	70	17	previous	previous	JJ
cord-283427-fef9qsik	70	18	studies	study	NNS
cord-283427-fef9qsik	70	19	to	to	TO
cord-283427-fef9qsik	70	20	establish	establish	VB
cord-283427-fef9qsik	70	21	positive	positive	JJ
cord-283427-fef9qsik	70	22	control	control	NN
cord-283427-fef9qsik	70	23	.	.	.
cord-283427-fef9qsik	71	1	These	these	DT
cord-283427-fef9qsik	71	2	primer	primer	NN
cord-283427-fef9qsik	71	3	sequences	sequence	NNS
cord-283427-fef9qsik	71	4	were	be	VBD
cord-283427-fef9qsik	71	5	obtained	obtain	VBN
cord-283427-fef9qsik	71	6	from	from	IN
cord-283427-fef9qsik	71	7	the	the	DT
cord-283427-fef9qsik	71	8	National	National	NNP
cord-283427-fef9qsik	71	9	Center	Center	NNP
cord-283427-fef9qsik	71	10	for	for	IN
cord-283427-fef9qsik	71	11	Biotechnology	Biotechnology	NNP
cord-283427-fef9qsik	71	12	Information	Information	NNP
cord-283427-fef9qsik	71	13	nucleotide	nucleotide	JJ
cord-283427-fef9qsik	71	14	database	database	NN
cord-283427-fef9qsik	71	15	and	and	CC
cord-283427-fef9qsik	71	16	are	be	VBP
cord-283427-fef9qsik	71	17	shown	show	VBN
cord-283427-fef9qsik	71	18	in	in	IN
cord-283427-fef9qsik	71	19	Table	Table	NNP
cord-283427-fef9qsik	71	20	1	1	CD
cord-283427-fef9qsik	71	21	.	.	.
cord-283427-fef9qsik	72	1	Data	datum	NNS
cord-283427-fef9qsik	72	2	are	be	VBP
cord-283427-fef9qsik	72	3	presented	present	VBN
cord-283427-fef9qsik	72	4	as	as	IN
cord-283427-fef9qsik	72	5	mean	mean	JJ
cord-283427-fef9qsik	72	6	±	±	NNP
cord-283427-fef9qsik	72	7	SE	SE	NNP
cord-283427-fef9qsik	72	8	or	or	CC
cord-283427-fef9qsik	72	9	mean	mean	VB
cord-283427-fef9qsik	72	10	±	±	NNP
cord-283427-fef9qsik	72	11	SEM	SEM	NNP
cord-283427-fef9qsik	72	12	values	value	NNS
cord-283427-fef9qsik	72	13	for	for	IN
cord-283427-fef9qsik	72	14	each	each	DT
cord-283427-fef9qsik	72	15	experimental	experimental	JJ
cord-283427-fef9qsik	72	16	group	group	NN
cord-283427-fef9qsik	72	17	.	.	.
cord-283427-fef9qsik	73	1	Differences	difference	NNS
cord-283427-fef9qsik	73	2	between	between	IN
cord-283427-fef9qsik	73	3	means	mean	NNS
cord-283427-fef9qsik	73	4	were	be	VBD
cord-283427-fef9qsik	73	5	analyzed	analyze	VBN
cord-283427-fef9qsik	73	6	by	by	IN
cord-283427-fef9qsik	73	7	using	use	VBG
cord-283427-fef9qsik	73	8	Student	Student	NNP
cord-283427-fef9qsik	73	9	's	's	POS
cord-283427-fef9qsik	73	10	t	t	NN
cord-283427-fef9qsik	73	11	-	-	HYPH
cord-283427-fef9qsik	73	12	test	test	NN
cord-283427-fef9qsik	73	13	for	for	IN
cord-283427-fef9qsik	73	14	single	single	JJ
cord-283427-fef9qsik	73	15	comparisons	comparison	NNS
cord-283427-fef9qsik	73	16	.	.	.
cord-283427-fef9qsik	74	1	P	p	NN
cord-283427-fef9qsik	74	2	values	value	NNS
cord-283427-fef9qsik	74	3	<	<	XX
cord-283427-fef9qsik	74	4	0.05	0.05	CD
cord-283427-fef9qsik	74	5	were	be	VBD
cord-283427-fef9qsik	74	6	considered	consider	VBN
cord-283427-fef9qsik	74	7	statistically	statistically	RB
cord-283427-fef9qsik	74	8	significant	significant	JJ
cord-283427-fef9qsik	74	9	.	.	.
cord-283427-fef9qsik	75	1	After	after	IN
cord-283427-fef9qsik	75	2	i.p	i.p	NNP
cord-283427-fef9qsik	75	3	injection	injection	NN
cord-283427-fef9qsik	75	4	of	of	IN
cord-283427-fef9qsik	75	5	PBS	PBS	NNP
cord-283427-fef9qsik	75	6	,	,	,
cord-283427-fef9qsik	75	7	LPS	LPS	NNP
cord-283427-fef9qsik	75	8	(	(	-LRB-
cord-283427-fef9qsik	75	9	1.0	1.0	CD
cord-283427-fef9qsik	75	10	mg/4	mg/4	CD
cord-283427-fef9qsik	75	11	ml	ml	NN
cord-283427-fef9qsik	75	12	/	/	SYM
cord-283427-fef9qsik	75	13	kg	kg	NNP
cord-283427-fef9qsik	75	14	)	)	-RRB-
cord-283427-fef9qsik	75	15	and	and	CC
cord-283427-fef9qsik	75	16	two	two	CD
cord-283427-fef9qsik	75	17	vaccines	vaccine	NNS
cord-283427-fef9qsik	75	18	at	at	IN
cord-283427-fef9qsik	75	19	three	three	CD
cord-283427-fef9qsik	75	20	concentrations	concentration	NNS
cord-283427-fef9qsik	75	21	,	,	,
cord-283427-fef9qsik	75	22	the	the	DT
cord-283427-fef9qsik	75	23	permeability	permeability	NN
cord-283427-fef9qsik	75	24	of	of	IN
cord-283427-fef9qsik	75	25	EB	EB	NNP
cord-283427-fef9qsik	75	26	dye	dye	NN
cord-283427-fef9qsik	75	27	in	in	IN
cord-283427-fef9qsik	75	28	brain	brain	NN
cord-283427-fef9qsik	75	29	parenchyma	parenchyma	NN
cord-283427-fef9qsik	75	30	was	be	VBD
cord-283427-fef9qsik	75	31	measured	measure	VBN
cord-283427-fef9qsik	75	32	by	by	IN
cord-283427-fef9qsik	75	33	the	the	DT
cord-283427-fef9qsik	75	34	ratio	ratio	NN
cord-283427-fef9qsik	75	35	of	of	IN
cord-283427-fef9qsik	75	36	the	the	DT
cord-283427-fef9qsik	75	37	amount	amount	NN
cord-283427-fef9qsik	75	38	of	of	IN
cord-283427-fef9qsik	75	39	EB	EB	NNP
cord-283427-fef9qsik	75	40	dye	dye	NN
cord-283427-fef9qsik	75	41	in	in	IN
cord-283427-fef9qsik	75	42	brain	brain	NN
cord-283427-fef9qsik	75	43	to	to	IN
cord-283427-fef9qsik	75	44	the	the	DT
cord-283427-fef9qsik	75	45	amount	amount	NN
cord-283427-fef9qsik	75	46	of	of	IN
cord-283427-fef9qsik	75	47	EB	EB	NNP
cord-283427-fef9qsik	75	48	dye	dye	NN
cord-283427-fef9qsik	75	49	in	in	IN
cord-283427-fef9qsik	75	50	blood	blood	NN
cord-283427-fef9qsik	75	51	(	(	-LRB-
cord-283427-fef9qsik	75	52	Fig	Fig	NNP
cord-283427-fef9qsik	75	53	.	.	.
cord-283427-fef9qsik	75	54	1	1	CD
cord-283427-fef9qsik	75	55	)	)	-RRB-
cord-283427-fef9qsik	75	56	.	.	.
cord-283427-fef9qsik	76	1	In	in	IN
cord-283427-fef9qsik	76	2	the	the	DT
cord-283427-fef9qsik	76	3	first	first	JJ
cord-283427-fef9qsik	76	4	injection	injection	NN
cord-283427-fef9qsik	76	5	before	before	IN
cord-283427-fef9qsik	76	6	EB	EB	NNP
cord-283427-fef9qsik	76	7	injection	injection	NN
cord-283427-fef9qsik	76	8	,	,	,
cord-283427-fef9qsik	76	9	the	the	DT
cord-283427-fef9qsik	76	10	result	result	NN
cord-283427-fef9qsik	76	11	of	of	IN
cord-283427-fef9qsik	76	12	the	the	DT
cord-283427-fef9qsik	76	13	group	group	NN
cord-283427-fef9qsik	76	14	injected	inject	VBD
cord-283427-fef9qsik	76	15	PBS	PBS	NNP
cord-283427-fef9qsik	76	16	was	be	VBD
cord-283427-fef9qsik	76	17	negative	negative	JJ
cord-283427-fef9qsik	76	18	control	control	NN
cord-283427-fef9qsik	76	19	,	,	,
cord-283427-fef9qsik	76	20	and	and	CC
cord-283427-fef9qsik	76	21	the	the	DT
cord-283427-fef9qsik	76	22	result	result	NN
cord-283427-fef9qsik	76	23	of	of	IN
cord-283427-fef9qsik	76	24	the	the	DT
cord-283427-fef9qsik	76	25	group	group	NN
cord-283427-fef9qsik	76	26	injected	inject	VBN
cord-283427-fef9qsik	76	27	LPS	LPS	NNP
cord-283427-fef9qsik	76	28	was	be	VBD
cord-283427-fef9qsik	76	29	positive	positive	JJ
cord-283427-fef9qsik	76	30	control	control	NN
cord-283427-fef9qsik	76	31	.	.	.
cord-283427-fef9qsik	77	1	When	when	WRB
cord-283427-fef9qsik	77	2	compared	compare	VBN
cord-283427-fef9qsik	77	3	to	to	IN
cord-283427-fef9qsik	77	4	the	the	DT
cord-283427-fef9qsik	77	5	PBS	PBS	NNP
cord-283427-fef9qsik	77	6	/	/	SYM
cord-283427-fef9qsik	77	7	EB	EB	NNP
cord-283427-fef9qsik	77	8	group	group	NN
cord-283427-fef9qsik	77	9	,	,	,
cord-283427-fef9qsik	77	10	the	the	DT
cord-283427-fef9qsik	77	11	permeability	permeability	NN
cord-283427-fef9qsik	77	12	of	of	IN
cord-283427-fef9qsik	77	13	EB	EB	NNP
cord-283427-fef9qsik	77	14	dye	dye	NN
cord-283427-fef9qsik	77	15	was	be	VBD
cord-283427-fef9qsik	77	16	significantly	significantly	RB
cord-283427-fef9qsik	77	17	increased	increase	VBN
cord-283427-fef9qsik	77	18	in	in	IN
cord-283427-fef9qsik	77	19	mice	mouse	NNS
cord-283427-fef9qsik	77	20	of	of	IN
cord-283427-fef9qsik	77	21	the	the	DT
cord-283427-fef9qsik	77	22	group	group	NN
cord-283427-fef9qsik	77	23	injected	inject	VBN
cord-283427-fef9qsik	77	24	with	with	IN
cord-283427-fef9qsik	77	25	LPS	LPS	NNP
cord-283427-fef9qsik	77	26	/	/	SYM
cord-283427-fef9qsik	77	27	EB	EB	NNP
cord-283427-fef9qsik	77	28	(	(	-LRB-
cord-283427-fef9qsik	77	29	Figs.1a	Figs.1a	NNP
cord-283427-fef9qsik	77	30	and	and	CC
cord-283427-fef9qsik	77	31	b	b	LS
cord-283427-fef9qsik	77	32	)	)	-RRB-
cord-283427-fef9qsik	77	33	.	.	.
cord-283427-fef9qsik	78	1	The	the	DT
cord-283427-fef9qsik	78	2	EB	EB	NNP
cord-283427-fef9qsik	78	3	dye	dye	NN
cord-283427-fef9qsik	78	4	permeability	permeability	NN
cord-283427-fef9qsik	78	5	of	of	IN
cord-283427-fef9qsik	78	6	P1	P1	NNP
cord-283427-fef9qsik	78	7	group	group	NN
cord-283427-fef9qsik	78	8	(;	(;	-LRB-
cord-283427-fef9qsik	78	9	injected	inject	VBN
cord-283427-fef9qsik	78	10	with	with	IN
cord-283427-fef9qsik	78	11	2fold	2fold	CD
cord-283427-fef9qsik	78	12	concentration	concentration	NN
cord-283427-fef9qsik	78	13	of	of	IN
cord-283427-fef9qsik	78	14	porcine	porcine	JJ
cord-283427-fef9qsik	78	15	vaccine	vaccine	NN
cord-283427-fef9qsik	78	16	stock	stock	NN
cord-283427-fef9qsik	78	17	solution	solution	NN
cord-283427-fef9qsik	78	18	)	)	-RRB-
cord-283427-fef9qsik	78	19	and	and	CC
cord-283427-fef9qsik	78	20	P2	P2	NNP
cord-283427-fef9qsik	78	21	group	group	NN
cord-283427-fef9qsik	79	1	(;	(;	-LRB-
cord-283427-fef9qsik	79	2	injected	inject	VBN
cord-283427-fef9qsik	79	3	with	with	IN
cord-283427-fef9qsik	79	4	reference	reference	NN
cord-283427-fef9qsik	79	5	concentration	concentration	NN
cord-283427-fef9qsik	79	6	of	of	IN
cord-283427-fef9qsik	79	7	porcine	porcine	JJ
cord-283427-fef9qsik	79	8	vaccine	vaccine	NN
cord-283427-fef9qsik	79	9	stock	stock	NN
cord-283427-fef9qsik	79	10	solution	solution	NN
cord-283427-fef9qsik	79	11	)	)	-RRB-
cord-283427-fef9qsik	79	12	was	be	VBD
cord-283427-fef9qsik	79	13	increased	increase	VBN
cord-283427-fef9qsik	79	14	than	than	IN
cord-283427-fef9qsik	79	15	PBS/	PBS/	NNP
cord-283427-fef9qsik	79	16	EB	EB	NNP
cord-283427-fef9qsik	79	17	group	group	NN
cord-283427-fef9qsik	79	18	,	,	,
cord-283427-fef9qsik	79	19	but	but	CC
cord-283427-fef9qsik	79	20	not	not	RB
cord-283427-fef9qsik	79	21	significantly	significantly	RB
cord-283427-fef9qsik	79	22	,	,	,
cord-283427-fef9qsik	79	23	and	and	CC
cord-283427-fef9qsik	79	24	EB	EB	NNP
cord-283427-fef9qsik	79	25	dye	dye	NN
cord-283427-fef9qsik	79	26	penetrated	penetrate	VBD
cord-283427-fef9qsik	79	27	through	through	IN
cord-283427-fef9qsik	79	28	the	the	DT
cord-283427-fef9qsik	79	29	brain	brain	NN
cord-283427-fef9qsik	79	30	parenchyma	parenchyma	NN
cord-283427-fef9qsik	79	31	less	less	JJR
cord-283427-fef9qsik	79	32	than	than	IN
cord-283427-fef9qsik	79	33	LPS	LPS	NNP
cord-283427-fef9qsik	79	34	/	/	SYM
cord-283427-fef9qsik	79	35	EB	EB	NNP
cord-283427-fef9qsik	79	36	group	group	NN
cord-283427-fef9qsik	79	37	(	(	-LRB-
cord-283427-fef9qsik	79	38	Fig	Fig	NNP
cord-283427-fef9qsik	79	39	.	.	.
cord-283427-fef9qsik	79	40	1a	1a	CD
cord-283427-fef9qsik	79	41	)	)	-RRB-
cord-283427-fef9qsik	79	42	.	.	.
cord-283427-fef9qsik	80	1	However	however	RB
cord-283427-fef9qsik	80	2	,	,	,
cord-283427-fef9qsik	80	3	the	the	DT
cord-283427-fef9qsik	80	4	permeation	permeation	NN
cord-283427-fef9qsik	80	5	rate	rate	NN
cord-283427-fef9qsik	80	6	of	of	IN
cord-283427-fef9qsik	80	7	EB	EB	NNP
cord-283427-fef9qsik	80	8	dye	dye	NN
cord-283427-fef9qsik	80	9	in	in	IN
cord-283427-fef9qsik	80	10	C1	C1	NNP
cord-283427-fef9qsik	80	11	group	group	NN
cord-283427-fef9qsik	80	12	(;	(;	NN
cord-283427-fef9qsik	80	13	injected	inject	VBN
cord-283427-fef9qsik	80	14	with	with	IN
cord-283427-fef9qsik	80	15	2-fold	2-fold	CD
cord-283427-fef9qsik	80	16	concentration	concentration	NN
cord-283427-fef9qsik	80	17	of	of	IN
cord-283427-fef9qsik	80	18	canine	canine	JJ
cord-283427-fef9qsik	80	19	vaccine	vaccine	NN
cord-283427-fef9qsik	80	20	stock	stock	NN
cord-283427-fef9qsik	80	21	solution	solution	NN
cord-283427-fef9qsik	80	22	)	)	-RRB-
cord-283427-fef9qsik	80	23	was	be	VBD
cord-283427-fef9qsik	80	24	not	not	RB
cord-283427-fef9qsik	80	25	significant	significant	JJ
cord-283427-fef9qsik	80	26	but	but	CC
cord-283427-fef9qsik	80	27	higher	high	JJR
cord-283427-fef9qsik	80	28	than	than	IN
cord-283427-fef9qsik	80	29	LPS	LPS	NNP
cord-283427-fef9qsik	80	30	/	/	SYM
cord-283427-fef9qsik	80	31	EB	EB	NNP
cord-283427-fef9qsik	80	32	group	group	NN
cord-283427-fef9qsik	80	33	(	(	-LRB-
cord-283427-fef9qsik	80	34	Fig	Fig	NNP
cord-283427-fef9qsik	80	35	.	.	.
cord-283427-fef9qsik	80	36	1b	1b	CD
cord-283427-fef9qsik	80	37	)	)	-RRB-
cord-283427-fef9qsik	80	38	.	.	.
cord-283427-fef9qsik	81	1	The	the	DT
cord-283427-fef9qsik	81	2	10-fold	10-fold	JJ
cord-283427-fef9qsik	81	3	diluted	diluted	JJ
cord-283427-fef9qsik	81	4	group	group	NN
cord-283427-fef9qsik	81	5	of	of	IN
cord-283427-fef9qsik	81	6	the	the	DT
cord-283427-fef9qsik	81	7	two	two	CD
cord-283427-fef9qsik	81	8	vaccines	vaccine	NNS
cord-283427-fef9qsik	81	9	had	have	VBD
cord-283427-fef9qsik	81	10	similar	similar	JJ
cord-283427-fef9qsik	81	11	or	or	CC
cord-283427-fef9qsik	81	12	lower	low	JJR
cord-283427-fef9qsik	81	13	EB	EB	NNP
cord-283427-fef9qsik	81	14	dye	dye	NN
cord-283427-fef9qsik	81	15	permeability	permeability	NN
cord-283427-fef9qsik	81	16	than	than	IN
cord-283427-fef9qsik	81	17	the	the	DT
cord-283427-fef9qsik	81	18	PBS	PBS	NNP
cord-283427-fef9qsik	81	19	/	/	SYM
cord-283427-fef9qsik	81	20	EB	EB	NNP
cord-283427-fef9qsik	81	21	group	group	NN
cord-283427-fef9qsik	81	22	.	.	.
cord-283427-fef9qsik	82	1	The	the	DT
cord-283427-fef9qsik	82	2	relative	relative	JJ
cord-283427-fef9qsik	82	3	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	82	4	and	and	CC
cord-283427-fef9qsik	83	1	occludin	occludin	NNP
cord-283427-fef9qsik	83	2	mRNA	mRNA	NNP
cord-283427-fef9qsik	83	3	levels	level	NNS
cord-283427-fef9qsik	83	4	were	be	VBD
cord-283427-fef9qsik	83	5	plotted	plot	VBN
cord-283427-fef9qsik	83	6	on	on	IN
cord-283427-fef9qsik	83	7	the	the	DT
cord-283427-fef9qsik	83	8	graph	graph	NN
cord-283427-fef9qsik	83	9	after	after	IN
cord-283427-fef9qsik	83	10	4	4	CD
cord-283427-fef9qsik	83	11	h	h	NN
cord-283427-fef9qsik	83	12	after	after	IN
cord-283427-fef9qsik	83	13	i.p	i.p	NNP
cord-283427-fef9qsik	83	14	injection	injection	NN
cord-283427-fef9qsik	83	15	with	with	IN
cord-283427-fef9qsik	83	16	PBS	PBS	NNP
cord-283427-fef9qsik	83	17	,	,	,
cord-283427-fef9qsik	83	18	LPS	LPS	NNP
cord-283427-fef9qsik	83	19	,	,	,
cord-283427-fef9qsik	83	20	and	and	CC
cord-283427-fef9qsik	83	21	two	two	CD
cord-283427-fef9qsik	83	22	vaccines	vaccine	NNS
cord-283427-fef9qsik	83	23	at	at	IN
cord-283427-fef9qsik	83	24	three	three	CD
cord-283427-fef9qsik	83	25	concentrations	concentration	NNS
cord-283427-fef9qsik	83	26	(	(	-LRB-
cord-283427-fef9qsik	83	27	Fig	Fig	NNP
cord-283427-fef9qsik	83	28	.	.	NNP
cord-283427-fef9qsik	83	29	2	2	CD
cord-283427-fef9qsik	83	30	)	)	-RRB-
cord-283427-fef9qsik	83	31	.	.	.
cord-283427-fef9qsik	84	1	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	85	1	mRNA	mrna	NN
cord-283427-fef9qsik	85	2	levels	level	NNS
cord-283427-fef9qsik	85	3	were	be	VBD
cord-283427-fef9qsik	85	4	significantly	significantly	RB
cord-283427-fef9qsik	85	5	higher	high	JJR
cord-283427-fef9qsik	85	6	in	in	IN
cord-283427-fef9qsik	85	7	the	the	DT
cord-283427-fef9qsik	85	8	LPS	LPS	NNP
cord-283427-fef9qsik	85	9	group	group	NN
cord-283427-fef9qsik	85	10	(	(	-LRB-
cord-283427-fef9qsik	85	11	positive	positive	JJ
cord-283427-fef9qsik	85	12	control	control	NN
cord-283427-fef9qsik	85	13	)	)	-RRB-
cord-283427-fef9qsik	85	14	than	than	IN
cord-283427-fef9qsik	85	15	in	in	IN
cord-283427-fef9qsik	85	16	the	the	DT
cord-283427-fef9qsik	85	17	PBS	PBS	NNP
cord-283427-fef9qsik	85	18	group	group	NN
cord-283427-fef9qsik	85	19	(	(	-LRB-
cord-283427-fef9qsik	85	20	negative	negative	JJ
cord-283427-fef9qsik	85	21	control	control	NN
cord-283427-fef9qsik	85	22	)	)	-RRB-
cord-283427-fef9qsik	85	23	.	.	.
cord-283427-fef9qsik	86	1	In	in	IN
cord-283427-fef9qsik	86	2	addition	addition	NN
cord-283427-fef9qsik	86	3	,	,	,
cord-283427-fef9qsik	86	4	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	86	5	mRNA	mrna	NN
cord-283427-fef9qsik	86	6	levels	level	NNS
cord-283427-fef9qsik	86	7	were	be	VBD
cord-283427-fef9qsik	86	8	significantly	significantly	RB
cord-283427-fef9qsik	86	9	increased	increase	VBN
cord-283427-fef9qsik	86	10	compared	compare	VBN
cord-283427-fef9qsik	86	11	to	to	IN
cord-283427-fef9qsik	86	12	PBS	PBS	NNP
cord-283427-fef9qsik	86	13	group	group	NN
cord-283427-fef9qsik	86	14	when	when	WRB
cord-283427-fef9qsik	86	15	2-fold	2-fold	CD
cord-283427-fef9qsik	86	16	concentrations	concentration	NNS
cord-283427-fef9qsik	86	17	of	of	IN
cord-283427-fef9qsik	86	18	two	two	CD
cord-283427-fef9qsik	86	19	vaccine	vaccine	NN
cord-283427-fef9qsik	86	20	stock	stock	NN
cord-283427-fef9qsik	86	21	solutions	solution	NNS
cord-283427-fef9qsik	86	22	were	be	VBD
cord-283427-fef9qsik	86	23	injected	inject	VBN
cord-283427-fef9qsik	86	24	.	.	.
cord-283427-fef9qsik	87	1	At	at	IN
cord-283427-fef9qsik	87	2	the	the	DT
cord-283427-fef9qsik	87	3	2-fold	2-fold	CD
cord-283427-fef9qsik	87	4	concentration	concentration	NN
cord-283427-fef9qsik	87	5	of	of	IN
cord-283427-fef9qsik	87	6	the	the	DT
cord-283427-fef9qsik	87	7	stock	stock	NN
cord-283427-fef9qsik	87	8	solution	solution	NN
cord-283427-fef9qsik	87	9	,	,	,
cord-283427-fef9qsik	87	10	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	87	11	mRNA	mrna	NN
cord-283427-fef9qsik	87	12	expression	expression	NN
cord-283427-fef9qsik	87	13	was	be	VBD
cord-283427-fef9qsik	87	14	lower	low	JJR
cord-283427-fef9qsik	87	15	in	in	IN
cord-283427-fef9qsik	87	16	the	the	DT
cord-283427-fef9qsik	87	17	P1	P1	NNP
cord-283427-fef9qsik	87	18	group	group	NN
cord-283427-fef9qsik	87	19	(;	(;	-LRB-
cord-283427-fef9qsik	87	20	porcine	porcine	JJ
cord-283427-fef9qsik	87	21	vaccine	vaccine	NN
cord-283427-fef9qsik	87	22	)	)	-RRB-
cord-283427-fef9qsik	87	23	but	but	CC
cord-283427-fef9qsik	87	24	,	,	,
cord-283427-fef9qsik	87	25	higher	high	JJR
cord-283427-fef9qsik	87	26	in	in	IN
cord-283427-fef9qsik	87	27	the	the	DT
cord-283427-fef9qsik	87	28	C1	C1	NNP
cord-283427-fef9qsik	87	29	group	group	NN
cord-283427-fef9qsik	87	30	(;	(;	-LRB-
cord-283427-fef9qsik	87	31	canine	canine	JJ
cord-283427-fef9qsik	87	32	vaccine	vaccine	NN
cord-283427-fef9qsik	87	33	)	)	-RRB-
cord-283427-fef9qsik	87	34	than	than	IN
cord-283427-fef9qsik	87	35	the	the	DT
cord-283427-fef9qsik	87	36	LPS	LPS	NNP
cord-283427-fef9qsik	87	37	group	group	NN
cord-283427-fef9qsik	87	38	,	,	,
cord-283427-fef9qsik	87	39	but	but	CC
cord-283427-fef9qsik	87	40	not	not	RB
cord-283427-fef9qsik	87	41	significantly	significantly	RB
cord-283427-fef9qsik	87	42	.	.	.
cord-283427-fef9qsik	88	1	The	the	DT
cord-283427-fef9qsik	88	2	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	88	3	mRNA	mrna	NN
cord-283427-fef9qsik	88	4	expressions	expression	NNS
cord-283427-fef9qsik	88	5	were	be	VBD
cord-283427-fef9qsik	88	6	similar	similar	JJ
cord-283427-fef9qsik	88	7	or	or	CC
cord-283427-fef9qsik	88	8	slightly	slightly	RB
cord-283427-fef9qsik	88	9	higher	high	JJR
cord-283427-fef9qsik	88	10	in	in	IN
cord-283427-fef9qsik	88	11	the	the	DT
cord-283427-fef9qsik	88	12	P2	P2	NNP
cord-283427-fef9qsik	88	13	and	and	CC
cord-283427-fef9qsik	88	14	C2	C2	NNP
cord-283427-fef9qsik	88	15	groups	group	NNS
cord-283427-fef9qsik	89	1	(;	(;	JJ
cord-283427-fef9qsik	90	1	reference	reference	NN
cord-283427-fef9qsik	90	2	concentration	concentration	NN
cord-283427-fef9qsik	90	3	of	of	IN
cord-283427-fef9qsik	90	4	two	two	CD
cord-283427-fef9qsik	90	5	vaccines	vaccine	NNS
cord-283427-fef9qsik	90	6	stock	stock	NN
cord-283427-fef9qsik	90	7	solution	solution	NN
cord-283427-fef9qsik	90	8	)	)	-RRB-
cord-283427-fef9qsik	90	9	compared	compare	VBN
cord-283427-fef9qsik	90	10	to	to	IN
cord-283427-fef9qsik	90	11	the	the	DT
cord-283427-fef9qsik	90	12	PBS	PBS	NNP
cord-283427-fef9qsik	90	13	group	group	NN
cord-283427-fef9qsik	90	14	.	.	.
cord-283427-fef9qsik	91	1	And	and	CC
cord-283427-fef9qsik	91	2	the	the	DT
cord-283427-fef9qsik	91	3	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	91	4	mRNA	mrna	NN
cord-283427-fef9qsik	91	5	expression	expression	NN
cord-283427-fef9qsik	91	6	was	be	VBD
cord-283427-fef9qsik	91	7	similar	similar	JJ
cord-283427-fef9qsik	91	8	or	or	CC
cord-283427-fef9qsik	91	9	slightly	slightly	RB
cord-283427-fef9qsik	91	10	lower	low	JJR
cord-283427-fef9qsik	91	11	in	in	IN
cord-283427-fef9qsik	91	12	the	the	DT
cord-283427-fef9qsik	91	13	P3	P3	NNP
cord-283427-fef9qsik	91	14	and	and	CC
cord-283427-fef9qsik	91	15	C3	c3	NN
cord-283427-fef9qsik	91	16	groups	group	NNS
cord-283427-fef9qsik	92	1	(;	(;	VBG
cord-283427-fef9qsik	92	2	10-fold	10-fold	DT
cord-283427-fef9qsik	92	3	diluted	dilute	VBN
cord-283427-fef9qsik	92	4	concentration	concentration	NN
cord-283427-fef9qsik	92	5	of	of	IN
cord-283427-fef9qsik	92	6	two	two	CD
cord-283427-fef9qsik	92	7	vaccines	vaccine	NNS
cord-283427-fef9qsik	92	8	stock	stock	NN
cord-283427-fef9qsik	92	9	solution	solution	NN
cord-283427-fef9qsik	92	10	)	)	-RRB-
cord-283427-fef9qsik	93	1	compared	compare	VBN
cord-283427-fef9qsik	93	2	to	to	IN
cord-283427-fef9qsik	93	3	the	the	DT
cord-283427-fef9qsik	93	4	PBS	PBS	NNP
cord-283427-fef9qsik	93	5	group	group	NN
cord-283427-fef9qsik	93	6	.	.	.
cord-283427-fef9qsik	94	1	Likewise	likewise	RB
cord-283427-fef9qsik	94	2	,	,	,
cord-283427-fef9qsik	94	3	occludin	occludin	NNP
cord-283427-fef9qsik	94	4	mRNA	mrna	NN
cord-283427-fef9qsik	94	5	levels	level	NNS
cord-283427-fef9qsik	94	6	were	be	VBD
cord-283427-fef9qsik	94	7	significantly	significantly	RB
cord-283427-fef9qsik	94	8	higher	high	JJR
cord-283427-fef9qsik	94	9	in	in	IN
cord-283427-fef9qsik	94	10	the	the	DT
cord-283427-fef9qsik	94	11	LPS	LPS	NNP
cord-283427-fef9qsik	94	12	group	group	NN
cord-283427-fef9qsik	94	13	(	(	-LRB-
cord-283427-fef9qsik	94	14	positive	positive	JJ
cord-283427-fef9qsik	94	15	control	control	NN
cord-283427-fef9qsik	94	16	)	)	-RRB-
cord-283427-fef9qsik	94	17	than	than	IN
cord-283427-fef9qsik	94	18	in	in	IN
cord-283427-fef9qsik	94	19	the	the	DT
cord-283427-fef9qsik	94	20	PBS	PBS	NNP
cord-283427-fef9qsik	94	21	group	group	NN
cord-283427-fef9qsik	94	22	(	(	-LRB-
cord-283427-fef9qsik	94	23	negative	negative	JJ
cord-283427-fef9qsik	94	24	control	control	NN
cord-283427-fef9qsik	94	25	)	)	-RRB-
cord-283427-fef9qsik	94	26	.	.	.
cord-283427-fef9qsik	95	1	However	however	RB
cord-283427-fef9qsik	95	2	,	,	,
cord-283427-fef9qsik	95	3	when	when	WRB
cord-283427-fef9qsik	95	4	2-fold	2-fold	JJ
cord-283427-fef9qsik	95	5	concentrations	concentration	NNS
cord-283427-fef9qsik	95	6	of	of	IN
cord-283427-fef9qsik	95	7	two	two	CD
cord-283427-fef9qsik	95	8	vaccines	vaccine	NNS
cord-283427-fef9qsik	95	9	stock	stock	NN
cord-283427-fef9qsik	95	10	solutions	solution	NNS
cord-283427-fef9qsik	95	11	were	be	VBD
cord-283427-fef9qsik	95	12	injected	inject	VBN
cord-283427-fef9qsik	95	13	,	,	,
cord-283427-fef9qsik	95	14	occludin	occludin	NNP
cord-283427-fef9qsik	95	15	mRNA	mRNA	NNP
cord-283427-fef9qsik	95	16	expression	expression	NN
cord-283427-fef9qsik	95	17	was	be	VBD
cord-283427-fef9qsik	95	18	increased	increase	VBN
cord-283427-fef9qsik	95	19	compared	compare	VBN
cord-283427-fef9qsik	95	20	to	to	IN
cord-283427-fef9qsik	95	21	the	the	DT
cord-283427-fef9qsik	95	22	PBS	PBS	NNP
cord-283427-fef9qsik	95	23	group	group	NN
cord-283427-fef9qsik	95	24	,	,	,
cord-283427-fef9qsik	95	25	but	but	CC
cord-283427-fef9qsik	95	26	not	not	RB
cord-283427-fef9qsik	95	27	significantly	significantly	RB
cord-283427-fef9qsik	95	28	.	.	.
cord-283427-fef9qsik	96	1	In	in	IN
cord-283427-fef9qsik	96	2	addition	addition	NN
cord-283427-fef9qsik	96	3	,	,	,
cord-283427-fef9qsik	96	4	the	the	DT
cord-283427-fef9qsik	96	5	increase	increase	NN
cord-283427-fef9qsik	96	6	was	be	VBD
cord-283427-fef9qsik	96	7	smaller	small	JJR
cord-283427-fef9qsik	96	8	than	than	IN
cord-283427-fef9qsik	96	9	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	96	10	mRNA	mrna	NN
cord-283427-fef9qsik	96	11	level	level	NN
cord-283427-fef9qsik	96	12	.	.	.
cord-283427-fef9qsik	97	1	In	in	IN
cord-283427-fef9qsik	97	2	the	the	DT
cord-283427-fef9qsik	97	3	P2	P2	NNP
cord-283427-fef9qsik	97	4	,	,	,
cord-283427-fef9qsik	97	5	C2	C2	NNP
cord-283427-fef9qsik	97	6	,	,	,
cord-283427-fef9qsik	97	7	P3	P3	NNP
cord-283427-fef9qsik	97	8	and	and	CC
cord-283427-fef9qsik	97	9	C3	c3	NN
cord-283427-fef9qsik	97	10	groups	group	NNS
cord-283427-fef9qsik	97	11	injected	inject	VBN
cord-283427-fef9qsik	97	12	with	with	IN
cord-283427-fef9qsik	97	13	reference	reference	NN
cord-283427-fef9qsik	97	14	concentrations	concentration	NNS
cord-283427-fef9qsik	97	15	and	and	CC
cord-283427-fef9qsik	97	16	10-fold	10-fold	JJ
cord-283427-fef9qsik	97	17	diluted	diluted	JJ
cord-283427-fef9qsik	97	18	concentrations	concentration	NNS
cord-283427-fef9qsik	97	19	of	of	IN
cord-283427-fef9qsik	97	20	the	the	DT
cord-283427-fef9qsik	97	21	two	two	CD
cord-283427-fef9qsik	97	22	vaccines	vaccine	NNS
cord-283427-fef9qsik	97	23	,	,	,
cord-283427-fef9qsik	97	24	occludin	occludin	JJ
cord-283427-fef9qsik	97	25	expression	expression	NN
cord-283427-fef9qsik	97	26	was	be	VBD
cord-283427-fef9qsik	97	27	similar	similar	JJ
cord-283427-fef9qsik	97	28	or	or	CC
cord-283427-fef9qsik	97	29	slightly	slightly	RB
cord-283427-fef9qsik	97	30	higher	high	JJR
cord-283427-fef9qsik	97	31	than	than	IN
cord-283427-fef9qsik	97	32	the	the	DT
cord-283427-fef9qsik	97	33	PBS	PBS	NNP
cord-283427-fef9qsik	97	34	group	group	NN
cord-283427-fef9qsik	97	35	.	.	.
cord-283427-fef9qsik	98	1	Humans	human	NNS
cord-283427-fef9qsik	98	2	and	and	CC
cord-283427-fef9qsik	98	3	live	live	JJ
cord-283427-fef9qsik	98	4	stocks	stock	NNS
cord-283427-fef9qsik	98	5	are	be	VBP
cord-283427-fef9qsik	98	6	easily	easily	RB
cord-283427-fef9qsik	98	7	exposed	expose	VBN
cord-283427-fef9qsik	98	8	to	to	IN
cord-283427-fef9qsik	98	9	the	the	DT
cord-283427-fef9qsik	98	10	risk	risk	NN
cord-283427-fef9qsik	98	11	of	of	IN
cord-283427-fef9qsik	98	12	infectious	infectious	JJ
cord-283427-fef9qsik	98	13	diseases	disease	NNS
cord-283427-fef9qsik	98	14	caused	cause	VBN
cord-283427-fef9qsik	98	15	by	by	IN
cord-283427-fef9qsik	98	16	various	various	JJ
cord-283427-fef9qsik	98	17	micro	micro	NNS
cord-283427-fef9qsik	98	18	-	-	HYPH
cord-283427-fef9qsik	98	19	organisms	organism	NNS
cord-283427-fef9qsik	98	20	such	such	JJ
cord-283427-fef9qsik	98	21	as	as	IN
cord-283427-fef9qsik	98	22	bacteria	bacteria	NNS
cord-283427-fef9qsik	98	23	and	and	CC
cord-283427-fef9qsik	98	24	virus	virus	NN
cord-283427-fef9qsik	98	25	on	on	IN
cord-283427-fef9qsik	98	26	a	a	DT
cord-283427-fef9qsik	98	27	daily	daily	JJ
cord-283427-fef9qsik	98	28	basis	basis	NN
cord-283427-fef9qsik	98	29	.	.	.
cord-283427-fef9qsik	99	1	This	this	DT
cord-283427-fef9qsik	99	2	has	have	VBZ
cord-283427-fef9qsik	99	3	become	become	VBN
cord-283427-fef9qsik	99	4	a	a	DT
cord-283427-fef9qsik	99	5	very	very	RB
cord-283427-fef9qsik	99	6	important	important	JJ
cord-283427-fef9qsik	99	7	issue	issue	NN
cord-283427-fef9qsik	99	8	as	as	IN
cord-283427-fef9qsik	99	9	it	-PRON-	PRP
cord-283427-fef9qsik	99	10	affects	affect	VBZ
cord-283427-fef9qsik	99	11	health	health	NN
cord-283427-fef9qsik	99	12	in	in	IN
cord-283427-fef9qsik	99	13	our	-PRON-	PRP$
cord-283427-fef9qsik	99	14	daily	daily	JJ
cord-283427-fef9qsik	99	15	lives	life	NNS
cord-283427-fef9qsik	99	16	[	[	-LRB-
cord-283427-fef9qsik	99	17	1	1	CD
cord-283427-fef9qsik	99	18	]	]	-RRB-
cord-283427-fef9qsik	99	19	.	.	.
cord-283427-fef9qsik	100	1	Once	once	RB
cord-283427-fef9qsik	100	2	a	a	DT
cord-283427-fef9qsik	100	3	high	high	JJ
cord-283427-fef9qsik	100	4	contagious	contagious	JJ
cord-283427-fef9qsik	100	5	infectious	infectious	JJ
cord-283427-fef9qsik	100	6	disease	disease	NN
cord-283427-fef9qsik	100	7	occurs	occur	VBZ
cord-283427-fef9qsik	100	8	,	,	,
cord-283427-fef9qsik	100	9	it	-PRON-	PRP
cord-283427-fef9qsik	100	10	can	can	MD
cord-283427-fef9qsik	100	11	spread	spread	VB
cord-283427-fef9qsik	100	12	to	to	IN
cord-283427-fef9qsik	100	13	other	other	JJ
cord-283427-fef9qsik	100	14	countries	country	NNS
cord-283427-fef9qsik	100	15	in	in	IN
cord-283427-fef9qsik	100	16	an	an	DT
cord-283427-fef9qsik	100	17	instant	instant	NN
cord-283427-fef9qsik	100	18	[	[	-LRB-
cord-283427-fef9qsik	100	19	4	4	CD
cord-283427-fef9qsik	100	20	]	]	-RRB-
cord-283427-fef9qsik	100	21	.	.	.
cord-283427-fef9qsik	101	1	Thus	thus	RB
cord-283427-fef9qsik	101	2	,	,	,
cord-283427-fef9qsik	101	3	it	-PRON-	PRP
cord-283427-fef9qsik	101	4	is	be	VBZ
cord-283427-fef9qsik	101	5	not	not	RB
cord-283427-fef9qsik	101	6	limited	limited	JJ
cord-283427-fef9qsik	101	7	to	to	IN
cord-283427-fef9qsik	101	8	any	any	DT
cord-283427-fef9qsik	101	9	region	region	NN
cord-283427-fef9qsik	101	10	or	or	CC
cord-283427-fef9qsik	101	11	country	country	NN
cord-283427-fef9qsik	101	12	.	.	.
cord-283427-fef9qsik	102	1	Rapid	rapid	JJ
cord-283427-fef9qsik	102	2	supply	supply	NN
cord-283427-fef9qsik	102	3	of	of	IN
cord-283427-fef9qsik	102	4	vaccines	vaccine	NNS
cord-283427-fef9qsik	102	5	that	that	WDT
cord-283427-fef9qsik	102	6	are	be	VBP
cord-283427-fef9qsik	102	7	effective	effective	JJ
cord-283427-fef9qsik	102	8	in	in	IN
cord-283427-fef9qsik	102	9	emergency	emergency	NN
cord-283427-fef9qsik	102	10	situations	situation	NNS
cord-283427-fef9qsik	102	11	is	be	VBZ
cord-283427-fef9qsik	102	12	essential	essential	JJ
cord-283427-fef9qsik	102	13	to	to	TO
cord-283427-fef9qsik	102	14	prevent	prevent	VB
cord-283427-fef9qsik	102	15	the	the	DT
cord-283427-fef9qsik	102	16	spread	spread	NN
cord-283427-fef9qsik	102	17	of	of	IN
cord-283427-fef9qsik	102	18	such	such	JJ
cord-283427-fef9qsik	102	19	infectious	infectious	JJ
cord-283427-fef9qsik	102	20	diseases	disease	NNS
cord-283427-fef9qsik	102	21	[	[	-LRB-
cord-283427-fef9qsik	102	22	15	15	CD
cord-283427-fef9qsik	102	23	]	]	-RRB-
cord-283427-fef9qsik	102	24	.	.	.
cord-283427-fef9qsik	103	1	However	however	RB
cord-283427-fef9qsik	103	2	,	,	,
cord-283427-fef9qsik	103	3	in	in	IN
cord-283427-fef9qsik	103	4	urgent	urgent	JJ
cord-283427-fef9qsik	103	5	situation	situation	NN
cord-283427-fef9qsik	103	6	,	,	,
cord-283427-fef9qsik	103	7	both	both	CC
cord-283427-fef9qsik	103	8	quick	quick	JJ
cord-283427-fef9qsik	103	9	supply	supply	NN
cord-283427-fef9qsik	103	10	of	of	IN
cord-283427-fef9qsik	103	11	vaccine	vaccine	NN
cord-283427-fef9qsik	103	12	and	and	CC
cord-283427-fef9qsik	103	13	safe	safe	JJ
cord-283427-fef9qsik	103	14	vaccine	vaccine	NN
cord-283427-fef9qsik	103	15	are	be	VBP
cord-283427-fef9qsik	103	16	important	important	JJ
cord-283427-fef9qsik	103	17	.	.	.
cord-283427-fef9qsik	104	1	All	all	DT
cord-283427-fef9qsik	104	2	important	important	JJ
cord-283427-fef9qsik	104	3	biological	biological	JJ
cord-283427-fef9qsik	104	4	actions	action	NNS
cord-283427-fef9qsik	104	5	of	of	IN
cord-283427-fef9qsik	104	6	humans	human	NNS
cord-283427-fef9qsik	104	7	and	and	CC
cord-283427-fef9qsik	104	8	live	live	JJ
cord-283427-fef9qsik	104	9	stocks	stock	NNS
cord-283427-fef9qsik	104	10	are	be	VBP
cord-283427-fef9qsik	104	11	regulated	regulate	VBN
cord-283427-fef9qsik	104	12	and	and	CC
cord-283427-fef9qsik	104	13	maintained	maintain	VBN
cord-283427-fef9qsik	104	14	primarily	primarily	RB
cord-283427-fef9qsik	104	15	by	by	IN
cord-283427-fef9qsik	104	16	the	the	DT
cord-283427-fef9qsik	104	17	central	central	JJ
cord-283427-fef9qsik	104	18	nervous	nervous	JJ
cord-283427-fef9qsik	104	19	system	system	NN
cord-283427-fef9qsik	104	20	(	(	-LRB-
cord-283427-fef9qsik	104	21	CNS	CNS	NNP
cord-283427-fef9qsik	104	22	)	)	-RRB-
cord-283427-fef9qsik	104	23	,	,	,
cord-283427-fef9qsik	104	24	especially	especially	RB
cord-283427-fef9qsik	104	25	the	the	DT
cord-283427-fef9qsik	104	26	brain	brain	NN
cord-283427-fef9qsik	104	27	[	[	-LRB-
cord-283427-fef9qsik	104	28	1	1	CD
cord-283427-fef9qsik	104	29	,	,	,
cord-283427-fef9qsik	104	30	14	14	CD
cord-283427-fef9qsik	104	31	,	,	,
cord-283427-fef9qsik	104	32	16	16	CD
cord-283427-fef9qsik	104	33	]	]	-RRB-
cord-283427-fef9qsik	104	34	.	.	.
cord-283427-fef9qsik	105	1	Brain	brain	NN
cord-283427-fef9qsik	105	2	is	be	VBZ
cord-283427-fef9qsik	105	3	a	a	DT
cord-283427-fef9qsik	105	4	complex	complex	JJ
cord-283427-fef9qsik	105	5	network	network	NN
cord-283427-fef9qsik	105	6	of	of	IN
cord-283427-fef9qsik	105	7	numerous	numerous	JJ
cord-283427-fef9qsik	105	8	neurons	neuron	NNS
cord-283427-fef9qsik	105	9	.	.	.
cord-283427-fef9qsik	106	1	It	-PRON-	PRP
cord-283427-fef9qsik	106	2	is	be	VBZ
cord-283427-fef9qsik	106	3	an	an	DT
cord-283427-fef9qsik	106	4	important	important	JJ
cord-283427-fef9qsik	106	5	organ	organ	NN
cord-283427-fef9qsik	106	6	for	for	IN
cord-283427-fef9qsik	106	7	regulating	regulate	VBG
cord-283427-fef9qsik	106	8	body	body	NN
cord-283427-fef9qsik	106	9	homeostasis	homeostasis	NN
cord-283427-fef9qsik	106	10	,	,	,
cord-283427-fef9qsik	106	11	behaviors	behavior	NNS
cord-283427-fef9qsik	106	12	,	,	,
cord-283427-fef9qsik	106	13	memory	memory	NN
cord-283427-fef9qsik	106	14	,	,	,
cord-283427-fef9qsik	106	15	and	and	CC
cord-283427-fef9qsik	106	16	learning	learn	VBG
cord-283427-fef9qsik	106	17	[	[	-LRB-
cord-283427-fef9qsik	106	18	20	20	CD
cord-283427-fef9qsik	106	19	]	]	-RRB-
cord-283427-fef9qsik	106	20	[	[	-LRB-
cord-283427-fef9qsik	106	21	21	21	CD
cord-283427-fef9qsik	106	22	]	]	-RRB-
cord-283427-fef9qsik	106	23	[	[	-LRB-
cord-283427-fef9qsik	106	24	22	22	CD
cord-283427-fef9qsik	106	25	]	]	-RRB-
cord-283427-fef9qsik	106	26	.	.	.
cord-283427-fef9qsik	107	1	This	this	DT
cord-283427-fef9qsik	107	2	important	important	JJ
cord-283427-fef9qsik	107	3	organ	organ	NN
cord-283427-fef9qsik	107	4	is	be	VBZ
cord-283427-fef9qsik	107	5	protected	protect	VBN
cord-283427-fef9qsik	107	6	by	by	IN
cord-283427-fef9qsik	107	7	a	a	DT
cord-283427-fef9qsik	107	8	structure	structure	NN
cord-283427-fef9qsik	107	9	known	know	VBN
cord-283427-fef9qsik	107	10	as	as	IN
cord-283427-fef9qsik	107	11	the	the	DT
cord-283427-fef9qsik	107	12	bloodbrain	bloodbrain	NN
cord-283427-fef9qsik	107	13	barrier	barrier	NN
cord-283427-fef9qsik	107	14	(	(	-LRB-
cord-283427-fef9qsik	107	15	BBB	BBB	NNP
cord-283427-fef9qsik	107	16	)	)	-RRB-
cord-283427-fef9qsik	107	17	[	[	-LRB-
cord-283427-fef9qsik	107	18	8	8	CD
cord-283427-fef9qsik	107	19	]	]	-RRB-
cord-283427-fef9qsik	107	20	.	.	.
cord-283427-fef9qsik	108	1	Neurons	neuron	NNS
cord-283427-fef9qsik	108	2	in	in	IN
cord-283427-fef9qsik	108	3	the	the	DT
cord-283427-fef9qsik	108	4	brain	brain	NN
cord-283427-fef9qsik	108	5	and	and	CC
cord-283427-fef9qsik	108	6	spinal	spinal	JJ
cord-283427-fef9qsik	108	7	cord	cord	NN
cord-283427-fef9qsik	108	8	are	be	VBP
cord-283427-fef9qsik	108	9	in	in	IN
cord-283427-fef9qsik	108	10	directly	directly	RB
cord-283427-fef9qsik	108	11	contact	contact	NN
cord-283427-fef9qsik	108	12	with	with	IN
cord-283427-fef9qsik	108	13	cerebrospinal	cerebrospinal	JJ
cord-283427-fef9qsik	108	14	fluid	fluid	NN
cord-283427-fef9qsik	108	15	Sequences	sequence	NNS
cord-283427-fef9qsik	108	16	of	of	IN
cord-283427-fef9qsik	108	17	primers	primer	NNS
cord-283427-fef9qsik	108	18	used	use	VBN
cord-283427-fef9qsik	108	19	for	for	IN
cord-283427-fef9qsik	108	20	quantitative	quantitative	JJ
cord-283427-fef9qsik	108	21	real	real	JJ
cord-283427-fef9qsik	108	22	-	-	HYPH
cord-283427-fef9qsik	108	23	time	time	NN
cord-283427-fef9qsik	108	24	PCR	PCR	NNP
cord-283427-fef9qsik	108	25	analysis	analysis	NN
cord-283427-fef9qsik	108	26	.	.	.
cord-283427-fef9qsik	109	1	The	the	DT
cord-283427-fef9qsik	109	2	sequence	sequence	NN
cord-283427-fef9qsik	109	3	of	of	IN
cord-283427-fef9qsik	109	4	the	the	DT
cord-283427-fef9qsik	109	5	primers	primer	NNS
cord-283427-fef9qsik	109	6	was	be	VBD
cord-283427-fef9qsik	109	7	used	use	VBN
cord-283427-fef9qsik	109	8	with	with	IN
cord-283427-fef9qsik	109	9	reference	reference	NN
cord-283427-fef9qsik	109	10	to	to	IN
cord-283427-fef9qsik	109	11	the	the	DT
cord-283427-fef9qsik	109	12	previous	previous	JJ
cord-283427-fef9qsik	109	13	description	description	NN
cord-283427-fef9qsik	109	14	of	of	IN
cord-283427-fef9qsik	109	15	Baek	Baek	NNP
cord-283427-fef9qsik	109	16	et	et	NNP
cord-283427-fef9qsik	109	17	al	al	NNP
cord-283427-fef9qsik	109	18	.	.	.
cord-283427-fef9qsik	110	1	[	[	-LRB-
cord-283427-fef9qsik	110	2	1	1	CD
cord-283427-fef9qsik	110	3	]	]	-RRB-
cord-283427-fef9qsik	110	4	.	.	.
cord-283427-fef9qsik	111	1	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	112	1	,	,	,
cord-283427-fef9qsik	113	1	zonula	zonula	NNP
cord-283427-fef9qsik	113	2	occludens-1	occludens-1	NNP
cord-283427-fef9qsik	113	3	;	;	:
cord-283427-fef9qsik	113	4	GAPDH	GAPDH	NNP
cord-283427-fef9qsik	113	5	,	,	,
cord-283427-fef9qsik	113	6	glyceraldehyde	glyceraldehyde	NN
cord-283427-fef9qsik	113	7	3-phosphate	3-phosphate	CD
cord-283427-fef9qsik	113	8	dehydrogenase	dehydrogenase	NN
cord-283427-fef9qsik	113	9	(	(	-LRB-
cord-283427-fef9qsik	113	10	CSF	CSF	NNP
cord-283427-fef9qsik	113	11	)	)	-RRB-
cord-283427-fef9qsik	114	1	[	[	-LRB-
cord-283427-fef9qsik	114	2	19	19	CD
cord-283427-fef9qsik	114	3	]	]	-RRB-
cord-283427-fef9qsik	114	4	.	.	.
cord-283427-fef9qsik	115	1	They	-PRON-	PRP
cord-283427-fef9qsik	115	2	are	be	VBP
cord-283427-fef9qsik	115	3	supplied	supply	VBN
cord-283427-fef9qsik	115	4	with	with	IN
cord-283427-fef9qsik	115	5	oxygen	oxygen	NN
cord-283427-fef9qsik	115	6	and	and	CC
cord-283427-fef9qsik	115	7	nutrients	nutrient	NNS
cord-283427-fef9qsik	115	8	.	.	.
cord-283427-fef9qsik	116	1	When	when	WRB
cord-283427-fef9qsik	116	2	blood	blood	NN
cord-283427-fef9qsik	116	3	and	and	CC
cord-283427-fef9qsik	116	4	CSF	CSF	NNP
cord-283427-fef9qsik	116	5	circulate	circulate	VBP
cord-283427-fef9qsik	116	6	,	,	,
cord-283427-fef9qsik	116	7	the	the	DT
cord-283427-fef9qsik	116	8	material	material	NN
cord-283427-fef9qsik	116	9	can	can	MD
cord-283427-fef9qsik	116	10	selectively	selectively	RB
cord-283427-fef9qsik	116	11	penetrate	penetrate	VB
cord-283427-fef9qsik	116	12	because	because	IN
cord-283427-fef9qsik	116	13	the	the	DT
cord-283427-fef9qsik	116	14	BBB	BBB	NNP
cord-283427-fef9qsik	116	15	limits	limit	VBZ
cord-283427-fef9qsik	116	16	mass	mass	NN
cord-283427-fef9qsik	116	17	transfer	transfer	NN
cord-283427-fef9qsik	116	18	into	into	IN
cord-283427-fef9qsik	116	19	brain	brain	NN
cord-283427-fef9qsik	116	20	parenchyma	parenchyma	NN
cord-283427-fef9qsik	116	21	[	[	-LRB-
cord-283427-fef9qsik	116	22	11	11	CD
cord-283427-fef9qsik	116	23	,	,	,
cord-283427-fef9qsik	116	24	18	18	CD
cord-283427-fef9qsik	116	25	]	]	-RRB-
cord-283427-fef9qsik	116	26	.	.	.
cord-283427-fef9qsik	117	1	It	-PRON-	PRP
cord-283427-fef9qsik	117	2	is	be	VBZ
cord-283427-fef9qsik	117	3	believed	believe	VBN
cord-283427-fef9qsik	117	4	that	that	IN
cord-283427-fef9qsik	117	5	the	the	DT
cord-283427-fef9qsik	117	6	brain	brain	NN
cord-283427-fef9qsik	117	7	can	can	MD
cord-283427-fef9qsik	117	8	examine	examine	VB
cord-283427-fef9qsik	117	9	components	component	NNS
cord-283427-fef9qsik	117	10	of	of	IN
cord-283427-fef9qsik	117	11	blood	blood	NN
cord-283427-fef9qsik	117	12	and	and	CC
cord-283427-fef9qsik	117	13	only	only	RB
cord-283427-fef9qsik	117	14	let	let	VB
cord-283427-fef9qsik	117	15	required	require	VBN
cord-283427-fef9qsik	117	16	substances	substance	NNS
cord-283427-fef9qsik	117	17	selectively	selectively	RB
cord-283427-fef9qsik	117	18	pass	pass	VBP
cord-283427-fef9qsik	117	19	[	[	-LRB-
cord-283427-fef9qsik	117	20	2	2	CD
cord-283427-fef9qsik	117	21	]	]	-RRB-
cord-283427-fef9qsik	117	22	.	.	.
cord-283427-fef9qsik	118	1	If	if	IN
cord-283427-fef9qsik	118	2	the	the	DT
cord-283427-fef9qsik	118	3	BBB	BBB	NNP
cord-283427-fef9qsik	118	4	is	be	VBZ
cord-283427-fef9qsik	118	5	exposed	expose	VBN
cord-283427-fef9qsik	118	6	to	to	IN
cord-283427-fef9qsik	118	7	any	any	DT
cord-283427-fef9qsik	118	8	toxic	toxic	JJ
cord-283427-fef9qsik	118	9	substance	substance	NN
cord-283427-fef9qsik	118	10	,	,	,
cord-283427-fef9qsik	118	11	chronic	chronic	JJ
cord-283427-fef9qsik	118	12	high	high	JJ
cord-283427-fef9qsik	118	13	blood	blood	NN
cord-283427-fef9qsik	118	14	pressure	pressure	NN
cord-283427-fef9qsik	118	15	,	,	,
cord-283427-fef9qsik	118	16	radiation	radiation	NN
cord-283427-fef9qsik	118	17	,	,	,
cord-283427-fef9qsik	118	18	viruses	virus	NNS
cord-283427-fef9qsik	118	19	,	,	,
cord-283427-fef9qsik	118	20	or	or	CC
cord-283427-fef9qsik	118	21	bacteria	bacteria	NNS
cord-283427-fef9qsik	118	22	,	,	,
cord-283427-fef9qsik	118	23	it	-PRON-	PRP
cord-283427-fef9qsik	118	24	can	can	MD
cord-283427-fef9qsik	118	25	lead	lead	VB
cord-283427-fef9qsik	118	26	to	to	IN
cord-283427-fef9qsik	118	27	brain	brain	NN
cord-283427-fef9qsik	118	28	problem	problem	NN
cord-283427-fef9qsik	118	29	[	[	-LRB-
cord-283427-fef9qsik	118	30	3	3	CD
cord-283427-fef9qsik	118	31	,	,	,
cord-283427-fef9qsik	118	32	18	18	CD
cord-283427-fef9qsik	118	33	]	]	-RRB-
cord-283427-fef9qsik	118	34	.	.	.
cord-283427-fef9qsik	119	1	If	if	IN
cord-283427-fef9qsik	119	2	a	a	DT
cord-283427-fef9qsik	119	3	newly	newly	RB
cord-283427-fef9qsik	119	4	developed	develop	VBN
cord-283427-fef9qsik	119	5	vaccine	vaccine	NN
cord-283427-fef9qsik	119	6	or	or	CC
cord-283427-fef9qsik	119	7	urgent	urgent	JJ
cord-283427-fef9qsik	119	8	vaccine	vaccine	NN
cord-283427-fef9qsik	119	9	fails	fail	VBZ
cord-283427-fef9qsik	119	10	to	to	TO
cord-283427-fef9qsik	119	11	secure	secure	VB
cord-283427-fef9qsik	119	12	brain	brain	NN
cord-283427-fef9qsik	119	13	safety	safety	NN
cord-283427-fef9qsik	119	14	,	,	,
cord-283427-fef9qsik	119	15	brain	brain	NN
cord-283427-fef9qsik	119	16	parenchyma	parenchyma	NN
cord-283427-fef9qsik	119	17	might	may	MD
cord-283427-fef9qsik	119	18	become	become	VB
cord-283427-fef9qsik	119	19	damaged	damaged	JJ
cord-283427-fef9qsik	119	20	and	and	CC
cord-283427-fef9qsik	119	21	the	the	DT
cord-283427-fef9qsik	119	22	health	health	NN
cord-283427-fef9qsik	119	23	of	of	IN
cord-283427-fef9qsik	119	24	the	the	DT
cord-283427-fef9qsik	119	25	recipient	recipient	NN
cord-283427-fef9qsik	119	26	may	may	MD
cord-283427-fef9qsik	119	27	not	not	RB
cord-283427-fef9qsik	119	28	be	be	VB
cord-283427-fef9qsik	119	29	assured	assure	VBN
cord-283427-fef9qsik	119	30	[	[	-LRB-
cord-283427-fef9qsik	119	31	1	1	CD
cord-283427-fef9qsik	119	32	]	]	-RRB-
cord-283427-fef9qsik	119	33	.	.	.
cord-283427-fef9qsik	120	1	This	this	DT
cord-283427-fef9qsik	120	2	can	can	MD
cord-283427-fef9qsik	120	3	become	become	VB
cord-283427-fef9qsik	120	4	can	can	MD
cord-283427-fef9qsik	120	5	be	be	VB
cord-283427-fef9qsik	120	6	a	a	DT
cord-283427-fef9qsik	120	7	serious	serious	JJ
cord-283427-fef9qsik	120	8	public	public	JJ
cord-283427-fef9qsik	120	9	health	health	NN
cord-283427-fef9qsik	120	10	hazard	hazard	NN
cord-283427-fef9qsik	120	11	and	and	CC
cord-283427-fef9qsik	120	12	result	result	VB
cord-283427-fef9qsik	120	13	in	in	IN
cord-283427-fef9qsik	120	14	serious	serious	JJ
cord-283427-fef9qsik	120	15	economic	economic	JJ
cord-283427-fef9qsik	120	16	damage	damage	NN
cord-283427-fef9qsik	120	17	to	to	IN
cord-283427-fef9qsik	120	18	industrial	industrial	JJ
cord-283427-fef9qsik	120	19	animals	animal	NNS
cord-283427-fef9qsik	120	20	.	.	.
cord-283427-fef9qsik	121	1	Therefore	therefore	RB
cord-283427-fef9qsik	121	2	,	,	,
cord-283427-fef9qsik	121	3	the	the	DT
cord-283427-fef9qsik	121	4	safety	safety	NN
cord-283427-fef9qsik	121	5	assessment	assessment	NN
cord-283427-fef9qsik	121	6	module	module	NN
cord-283427-fef9qsik	121	7	we	-PRON-	PRP
cord-283427-fef9qsik	121	8	designed	design	VBD
cord-283427-fef9qsik	121	9	was	be	VBD
cord-283427-fef9qsik	121	10	focused	focus	VBN
cord-283427-fef9qsik	121	11	on	on	IN
cord-283427-fef9qsik	121	12	how	how	WRB
cord-283427-fef9qsik	121	13	to	to	TO
cord-283427-fef9qsik	121	14	effectively	effectively	RB
cord-283427-fef9qsik	121	15	measure	measure	VB
cord-283427-fef9qsik	121	16	effects	effect	NNS
cord-283427-fef9qsik	121	17	of	of	IN
cord-283427-fef9qsik	121	18	various	various	JJ
cord-283427-fef9qsik	121	19	vaccines	vaccine	NNS
cord-283427-fef9qsik	121	20	on	on	IN
cord-283427-fef9qsik	121	21	the	the	DT
cord-283427-fef9qsik	121	22	stability	stability	NN
cord-283427-fef9qsik	121	23	of	of	IN
cord-283427-fef9qsik	121	24	BBB	BBB	NNP
cord-283427-fef9qsik	121	25	in	in	IN
cord-283427-fef9qsik	121	26	laboratory	laboratory	NN
cord-283427-fef9qsik	121	27	animals	animal	NNS
cord-283427-fef9qsik	121	28	[	[	-LRB-
cord-283427-fef9qsik	121	29	1	1	CD
cord-283427-fef9qsik	121	30	]	]	-RRB-
cord-283427-fef9qsik	121	31	.	.	.
cord-283427-fef9qsik	122	1	The	the	DT
cord-283427-fef9qsik	122	2	BBB	BBB	NNP
cord-283427-fef9qsik	122	3	is	be	VBZ
cord-283427-fef9qsik	122	4	formed	form	VBN
cord-283427-fef9qsik	122	5	by	by	IN
cord-283427-fef9qsik	122	6	a	a	DT
cord-283427-fef9qsik	122	7	tight	tight	JJ
cord-283427-fef9qsik	122	8	junction	junction	NN
cord-283427-fef9qsik	122	9	between	between	IN
cord-283427-fef9qsik	122	10	endothelial	endothelial	JJ
cord-283427-fef9qsik	122	11	cells	cell	NNS
cord-283427-fef9qsik	122	12	of	of	IN
cord-283427-fef9qsik	122	13	blood	blood	NN
cord-283427-fef9qsik	122	14	vessels	vessel	NNS
cord-283427-fef9qsik	122	15	distributed	distribute	VBN
cord-283427-fef9qsik	122	16	throughout	throughout	IN
cord-283427-fef9qsik	122	17	the	the	DT
cord-283427-fef9qsik	122	18	CNS	CNS	NNP
cord-283427-fef9qsik	122	19	.	.	.
cord-283427-fef9qsik	123	1	It	-PRON-	PRP
cord-283427-fef9qsik	123	2	contains	contain	VBZ
cord-283427-fef9qsik	123	3	junctional	junctional	JJ
cord-283427-fef9qsik	123	4	molecules	molecule	NNS
cord-283427-fef9qsik	123	5	(	(	-LRB-
cord-283427-fef9qsik	123	6	JAM	JAM	NNP
cord-283427-fef9qsik	123	7	)	)	-RRB-
cord-283427-fef9qsik	123	8	,	,	.
cord-283427-fef9qsik	124	1	zonula	zonula	NNP
cord-283427-fef9qsik	124	2	occludens	occludens	NNP
cord-283427-fef9qsik	124	3	(	(	-LRB-
cord-283427-fef9qsik	124	4	ZO	ZO	NNP
cord-283427-fef9qsik	124	5	)	)	-RRB-
cord-283427-fef9qsik	124	6	,	,	,
cord-283427-fef9qsik	124	7	claudin	claudin	NNP
cord-283427-fef9qsik	124	8	,	,	,
cord-283427-fef9qsik	124	9	and	and	CC
cord-283427-fef9qsik	124	10	occluding	occlude	VBG
cord-283427-fef9qsik	124	11	[	[	-LRB-
cord-283427-fef9qsik	124	12	3	3	CD
cord-283427-fef9qsik	124	13	,	,	,
cord-283427-fef9qsik	124	14	[	[	-LRB-
cord-283427-fef9qsik	124	15	5	5	CD
cord-283427-fef9qsik	124	16	]	]	-RRB-
cord-283427-fef9qsik	124	17	[	[	-LRB-
cord-283427-fef9qsik	124	18	6	6	CD
cord-283427-fef9qsik	124	19	]	]	-RRB-
cord-283427-fef9qsik	124	20	[	[	-LRB-
cord-283427-fef9qsik	124	21	7	7	CD
cord-283427-fef9qsik	124	22	]	]	-RRB-
cord-283427-fef9qsik	125	1	[	[	-LRB-
cord-283427-fef9qsik	125	2	9	9	CD
cord-283427-fef9qsik	125	3	]	]	-RRB-
cord-283427-fef9qsik	125	4	[	[	-LRB-
cord-283427-fef9qsik	125	5	10	10	CD
cord-283427-fef9qsik	125	6	]	]	-RRB-
cord-283427-fef9qsik	125	7	[	[	-LRB-
cord-283427-fef9qsik	125	8	11	11	CD
cord-283427-fef9qsik	125	9	]	]	-RRB-
cord-283427-fef9qsik	125	10	[	[	-LRB-
cord-283427-fef9qsik	125	11	12	12	CD
cord-283427-fef9qsik	125	12	]	]	-RRB-
cord-283427-fef9qsik	125	13	.	.	.
cord-283427-fef9qsik	126	1	These	these	DT
cord-283427-fef9qsik	126	2	structures	structure	NNS
cord-283427-fef9qsik	126	3	are	be	VBP
cord-283427-fef9qsik	126	4	key	key	JJ
cord-283427-fef9qsik	126	5	components	component	NNS
cord-283427-fef9qsik	126	6	of	of	IN
cord-283427-fef9qsik	126	7	tight	tight	JJ
cord-283427-fef9qsik	126	8	junction	junction	NN
cord-283427-fef9qsik	126	9	of	of	IN
cord-283427-fef9qsik	126	10	BBB	BBB	NNP
cord-283427-fef9qsik	126	11	[	[	-LRB-
cord-283427-fef9qsik	126	12	3	3	CD
cord-283427-fef9qsik	126	13	,	,	,
cord-283427-fef9qsik	126	14	5	5	CD
cord-283427-fef9qsik	126	15	-	-	SYM
cord-283427-fef9qsik	126	16	7	7	CD
cord-283427-fef9qsik	126	17	,	,	,
cord-283427-fef9qsik	126	18	9	9	CD
cord-283427-fef9qsik	126	19	,	,	,
cord-283427-fef9qsik	126	20	10	10	CD
cord-283427-fef9qsik	126	21	]	]	-RRB-
cord-283427-fef9qsik	126	22	.	.	.
cord-283427-fef9qsik	127	1	In	in	IN
cord-283427-fef9qsik	127	2	our	-PRON-	PRP$
cord-283427-fef9qsik	127	3	previous	previous	JJ
cord-283427-fef9qsik	127	4	study	study	NN
cord-283427-fef9qsik	127	5	,	,	,
cord-283427-fef9qsik	127	6	we	-PRON-	PRP
cord-283427-fef9qsik	127	7	have	have	VBP
cord-283427-fef9qsik	127	8	established	establish	VBN
cord-283427-fef9qsik	127	9	a	a	DT
cord-283427-fef9qsik	127	10	condition	condition	NN
cord-283427-fef9qsik	127	11	for	for	IN
cord-283427-fef9qsik	127	12	positive	positive	JJ
cord-283427-fef9qsik	127	13	control	control	NN
cord-283427-fef9qsik	127	14	that	that	WDT
cord-283427-fef9qsik	127	15	can	can	MD
cord-283427-fef9qsik	127	16	destroy	destroy	VB
cord-283427-fef9qsik	127	17	the	the	DT
cord-283427-fef9qsik	127	18	BBB	BBB	NNP
cord-283427-fef9qsik	127	19	structure	structure	NN
cord-283427-fef9qsik	127	20	by	by	IN
cord-283427-fef9qsik	127	21	damage	damage	NN
cord-283427-fef9qsik	127	22	to	to	IN
cord-283427-fef9qsik	127	23	the	the	DT
cord-283427-fef9qsik	127	24	tight	tight	JJ
cord-283427-fef9qsik	127	25	junction	junction	NN
cord-283427-fef9qsik	127	26	using	use	VBG
cord-283427-fef9qsik	127	27	LPS	LPS	NNP
cord-283427-fef9qsik	127	28	mentioned	mention	VBD
cord-283427-fef9qsik	127	29	earlier	early	RBR
cord-283427-fef9qsik	127	30	[	[	-LRB-
cord-283427-fef9qsik	127	31	1	1	CD
cord-283427-fef9qsik	127	32	]	]	-RRB-
cord-283427-fef9qsik	127	33	.	.	.
cord-283427-fef9qsik	128	1	These	these	DT
cord-283427-fef9qsik	128	2	conditions	condition	NNS
cord-283427-fef9qsik	128	3	include	include	VBP
cord-283427-fef9qsik	128	4	mouse	mouse	NN
cord-283427-fef9qsik	128	5	species	specie	NNS
cord-283427-fef9qsik	128	6	,	,	,
cord-283427-fef9qsik	128	7	age	age	NN
cord-283427-fef9qsik	128	8	,	,	,
cord-283427-fef9qsik	128	9	type	type	NN
cord-283427-fef9qsik	128	10	,	,	,
cord-283427-fef9qsik	128	11	concentration	concentration	NN
cord-283427-fef9qsik	128	12	of	of	IN
cord-283427-fef9qsik	128	13	LPS	LPS	NNP
cord-283427-fef9qsik	128	14	,	,	,
cord-283427-fef9qsik	128	15	injection	injection	NN
cord-283427-fef9qsik	128	16	routes	route	NNS
cord-283427-fef9qsik	128	17	to	to	IN
cord-283427-fef9qsik	128	18	mice	mouse	NNS
cord-283427-fef9qsik	128	19	,	,	,
cord-283427-fef9qsik	128	20	and	and	CC
cord-283427-fef9qsik	128	21	exposure	exposure	NN
cord-283427-fef9qsik	128	22	time	time	NN
cord-283427-fef9qsik	128	23	after	after	IN
cord-283427-fef9qsik	128	24	injection	injection	NN
cord-283427-fef9qsik	128	25	.	.	.
cord-283427-fef9qsik	129	1	EB	EB	NNP
cord-283427-fef9qsik	129	2	assay	assay	NN
cord-283427-fef9qsik	129	3	,	,	,
cord-283427-fef9qsik	129	4	qPCR	qPCR	NNP
cord-283427-fef9qsik	129	5	,	,	,
cord-283427-fef9qsik	129	6	and	and	CC
cord-283427-fef9qsik	129	7	Western	western	JJ
cord-283427-fef9qsik	129	8	blot	blot	NN
cord-283427-fef9qsik	129	9	analysis	analysis	NN
cord-283427-fef9qsik	129	10	can	can	MD
cord-283427-fef9qsik	129	11	be	be	VB
cord-283427-fef9qsik	129	12	conducted	conduct	VBN
cord-283427-fef9qsik	129	13	under	under	IN
cord-283427-fef9qsik	129	14	the	the	DT
cord-283427-fef9qsik	129	15	condition	condition	NN
cord-283427-fef9qsik	129	16	of	of	IN
cord-283427-fef9qsik	129	17	positive	positive	JJ
cord-283427-fef9qsik	129	18	control	control	NN
cord-283427-fef9qsik	129	19	to	to	TO
cord-283427-fef9qsik	129	20	determine	determine	VB
cord-283427-fef9qsik	129	21	whether	whether	IN
cord-283427-fef9qsik	129	22	the	the	DT
cord-283427-fef9qsik	129	23	BBB	BBB	NNP
cord-283427-fef9qsik	129	24	is	be	VBZ
cord-283427-fef9qsik	129	25	destroyed	destroy	VBN
cord-283427-fef9qsik	129	26	[	[	-LRB-
cord-283427-fef9qsik	129	27	2	2	CD
cord-283427-fef9qsik	129	28	,	,	,
cord-283427-fef9qsik	129	29	3	3	CD
cord-283427-fef9qsik	129	30	,	,	,
cord-283427-fef9qsik	129	31	9	9	CD
cord-283427-fef9qsik	129	32	,	,	,
cord-283427-fef9qsik	129	33	11	11	CD
cord-283427-fef9qsik	129	34	,	,	,
cord-283427-fef9qsik	129	35	13	13	CD
cord-283427-fef9qsik	129	36	,	,	,
cord-283427-fef9qsik	129	37	17	17	CD
cord-283427-fef9qsik	129	38	,	,	,
cord-283427-fef9qsik	129	39	18	18	CD
cord-283427-fef9qsik	129	40	]	]	-RRB-
cord-283427-fef9qsik	129	41	.	.	.
cord-283427-fef9qsik	130	1	In	in	IN
cord-283427-fef9qsik	130	2	the	the	DT
cord-283427-fef9qsik	130	3	present	present	JJ
cord-283427-fef9qsik	130	4	study	study	NN
cord-283427-fef9qsik	130	5	,	,	,
cord-283427-fef9qsik	130	6	we	-PRON-	PRP
cord-283427-fef9qsik	130	7	confirmed	confirm	VBD
cord-283427-fef9qsik	130	8	that	that	IN
cord-283427-fef9qsik	130	9	these	these	DT
cord-283427-fef9qsik	130	10	established	establish	VBN
cord-283427-fef9qsik	130	11	conditions	condition	NNS
cord-283427-fef9qsik	130	12	and	and	CC
cord-283427-fef9qsik	130	13	modules	module	NNS
cord-283427-fef9qsik	130	14	of	of	IN
cord-283427-fef9qsik	130	15	the	the	DT
cord-283427-fef9qsik	130	16	positive	positive	JJ
cord-283427-fef9qsik	130	17	control	control	NN
cord-283427-fef9qsik	130	18	that	that	WDT
cord-283427-fef9qsik	130	19	destroyed	destroy	VBD
cord-283427-fef9qsik	130	20	the	the	DT
cord-283427-fef9qsik	130	21	BBB	BBB	NNP
cord-283427-fef9qsik	130	22	could	could	MD
cord-283427-fef9qsik	130	23	be	be	VB
cord-283427-fef9qsik	130	24	used	use	VBN
cord-283427-fef9qsik	130	25	to	to	TO
cord-283427-fef9qsik	130	26	assess	assess	VB
cord-283427-fef9qsik	130	27	brain	brain	NN
cord-283427-fef9qsik	130	28	safety	safety	NN
cord-283427-fef9qsik	130	29	of	of	IN
cord-283427-fef9qsik	130	30	commercial	commercial	JJ
cord-283427-fef9qsik	130	31	vaccines	vaccine	NNS
cord-283427-fef9qsik	130	32	[	[	-LRB-
cord-283427-fef9qsik	130	33	1	1	CD
cord-283427-fef9qsik	130	34	]	]	-RRB-
cord-283427-fef9qsik	130	35	.	.	.
cord-283427-fef9qsik	131	1	Results	result	NNS
cord-283427-fef9qsik	131	2	of	of	IN
cord-283427-fef9qsik	131	3	EB	EB	NNP
cord-283427-fef9qsik	131	4	assay	assay	NN
cord-283427-fef9qsik	131	5	revealed	reveal	VBD
cord-283427-fef9qsik	131	6	that	that	IN
cord-283427-fef9qsik	131	7	EB	EB	NNP
cord-283427-fef9qsik	131	8	dye	dye	NN
cord-283427-fef9qsik	131	9	permeability	permeability	NN
cord-283427-fef9qsik	131	10	of	of	IN
cord-283427-fef9qsik	131	11	P1	P1	NNP
cord-283427-fef9qsik	131	12	group	group	NN
cord-283427-fef9qsik	131	13	was	be	VBD
cord-283427-fef9qsik	131	14	higher	high	JJR
cord-283427-fef9qsik	131	15	than	than	IN
cord-283427-fef9qsik	131	16	that	that	DT
cord-283427-fef9qsik	131	17	of	of	IN
cord-283427-fef9qsik	131	18	the	the	DT
cord-283427-fef9qsik	131	19	PBS	PBS	NNP
cord-283427-fef9qsik	131	20	/	/	SYM
cord-283427-fef9qsik	131	21	EB	EB	NNP
cord-283427-fef9qsik	131	22	group	group	NN
cord-283427-fef9qsik	131	23	but	but	CC
cord-283427-fef9qsik	131	24	lower	low	JJR
cord-283427-fef9qsik	131	25	than	than	IN
cord-283427-fef9qsik	131	26	that	that	DT
cord-283427-fef9qsik	131	27	of	of	IN
cord-283427-fef9qsik	131	28	the	the	DT
cord-283427-fef9qsik	131	29	LPS	LPS	NNP
cord-283427-fef9qsik	131	30	/	/	SYM
cord-283427-fef9qsik	131	31	EB	EB	NNP
cord-283427-fef9qsik	131	32	group	group	NN
cord-283427-fef9qsik	131	33	.	.	.
cord-283427-fef9qsik	132	1	Based	base	VBN
cord-283427-fef9qsik	132	2	on	on	IN
cord-283427-fef9qsik	132	3	this	this	DT
cord-283427-fef9qsik	132	4	,	,	,
cord-283427-fef9qsik	132	5	we	-PRON-	PRP
cord-283427-fef9qsik	132	6	could	could	MD
cord-283427-fef9qsik	132	7	not	not	RB
cord-283427-fef9qsik	132	8	conclude	conclude	VB
cord-283427-fef9qsik	132	9	that	that	IN
cord-283427-fef9qsik	132	10	the	the	DT
cord-283427-fef9qsik	132	11	BBB	BBB	NNP
cord-283427-fef9qsik	132	12	was	be	VBD
cord-283427-fef9qsik	132	13	damaged	damage	VBN
cord-283427-fef9qsik	132	14	in	in	IN
cord-283427-fef9qsik	132	15	the	the	DT
cord-283427-fef9qsik	132	16	vaccine	vaccine	NN
cord-283427-fef9qsik	132	17	concentration	concentration	NN
cord-283427-fef9qsik	132	18	of	of	IN
cord-283427-fef9qsik	132	19	the	the	DT
cord-283427-fef9qsik	132	20	P1	P1	NNP
cord-283427-fef9qsik	132	21	group	group	NN
cord-283427-fef9qsik	132	22	.	.	.
cord-283427-fef9qsik	133	1	On	on	IN
cord-283427-fef9qsik	133	2	the	the	DT
cord-283427-fef9qsik	133	3	other	other	JJ
cord-283427-fef9qsik	133	4	hand	hand	NN
cord-283427-fef9qsik	133	5	,	,	,
cord-283427-fef9qsik	133	6	the	the	DT
cord-283427-fef9qsik	133	7	permeability	permeability	NN
cord-283427-fef9qsik	133	8	of	of	IN
cord-283427-fef9qsik	133	9	EB	EB	NNP
cord-283427-fef9qsik	133	10	dye	dye	NN
cord-283427-fef9qsik	133	11	in	in	IN
cord-283427-fef9qsik	133	12	the	the	DT
cord-283427-fef9qsik	133	13	C1	C1	NNP
cord-283427-fef9qsik	133	14	group	group	NN
cord-283427-fef9qsik	133	15	was	be	VBD
cord-283427-fef9qsik	133	16	similar	similar	JJ
cord-283427-fef9qsik	133	17	or	or	CC
cord-283427-fef9qsik	133	18	higher	high	JJR
cord-283427-fef9qsik	133	19	than	than	IN
cord-283427-fef9qsik	133	20	that	that	DT
cord-283427-fef9qsik	133	21	in	in	IN
cord-283427-fef9qsik	133	22	the	the	DT
cord-283427-fef9qsik	133	23	LPS	LPS	NNP
cord-283427-fef9qsik	133	24	/	/	SYM
cord-283427-fef9qsik	133	25	EB	EB	NNP
cord-283427-fef9qsik	133	26	group	group	NN
cord-283427-fef9qsik	133	27	,	,	,
cord-283427-fef9qsik	133	28	meaning	mean	VBG
cord-283427-fef9qsik	133	29	that	that	IN
cord-283427-fef9qsik	133	30	BBB	BBB	NNP
cord-283427-fef9qsik	133	31	was	be	VBD
cord-283427-fef9qsik	133	32	damaged	damage	VBN
cord-283427-fef9qsik	133	33	at	at	IN
cord-283427-fef9qsik	133	34	vaccine	vaccine	NN
cord-283427-fef9qsik	133	35	concentration	concentration	NN
cord-283427-fef9qsik	133	36	of	of	IN
cord-283427-fef9qsik	133	37	C1	C1	NNP
cord-283427-fef9qsik	133	38	group	group	NN
cord-283427-fef9qsik	133	39	.	.	.
cord-283427-fef9qsik	134	1	The	the	DT
cord-283427-fef9qsik	134	2	same	same	JJ
cord-283427-fef9qsik	134	3	concentration	concentration	NN
cord-283427-fef9qsik	134	4	of	of	IN
cord-283427-fef9qsik	134	5	vaccine	vaccine	NN
cord-283427-fef9qsik	134	6	was	be	VBD
cord-283427-fef9qsik	134	7	injected	inject	VBN
cord-283427-fef9qsik	134	8	.	.	.
cord-283427-fef9qsik	135	1	However	however	RB
cord-283427-fef9qsik	135	2	,	,	,
cord-283427-fef9qsik	135	3	higher	high	JJR
cord-283427-fef9qsik	135	4	permeability	permeability	NN
cord-283427-fef9qsik	135	5	of	of	IN
cord-283427-fef9qsik	135	6	EB	EB	NNP
cord-283427-fef9qsik	135	7	dye	dye	NN
cord-283427-fef9qsik	135	8	was	be	VBD
cord-283427-fef9qsik	135	9	seen	see	VBN
cord-283427-fef9qsik	135	10	in	in	IN
cord-283427-fef9qsik	135	11	the	the	DT
cord-283427-fef9qsik	135	12	C1	C1	NNP
cord-283427-fef9qsik	135	13	group	group	NN
cord-283427-fef9qsik	135	14	.	.	.
cord-283427-fef9qsik	136	1	This	this	DT
cord-283427-fef9qsik	136	2	result	result	NN
cord-283427-fef9qsik	136	3	may	may	MD
cord-283427-fef9qsik	136	4	be	be	VB
cord-283427-fef9qsik	136	5	due	due	JJ
cord-283427-fef9qsik	136	6	to	to	IN
cord-283427-fef9qsik	136	7	different	different	JJ
cord-283427-fef9qsik	136	8	vaccine	vaccine	NN
cord-283427-fef9qsik	136	9	types	type	NNS
cord-283427-fef9qsik	136	10	of	of	IN
cord-283427-fef9qsik	136	11	porcine	porcine	JJ
cord-283427-fef9qsik	136	12	and	and	CC
cord-283427-fef9qsik	136	13	canine	canine	JJ
cord-283427-fef9qsik	136	14	vaccines	vaccine	NNS
cord-283427-fef9qsik	136	15	.	.	.
cord-283427-fef9qsik	137	1	Since	since	IN
cord-283427-fef9qsik	137	2	the	the	DT
cord-283427-fef9qsik	137	3	porcine	porcine	JJ
cord-283427-fef9qsik	137	4	vaccine	vaccine	NN
cord-283427-fef9qsik	137	5	is	be	VBZ
cord-283427-fef9qsik	137	6	a	a	DT
cord-283427-fef9qsik	137	7	killed	kill	VBN
cord-283427-fef9qsik	137	8	-	-	HYPH
cord-283427-fef9qsik	137	9	vaccine	vaccine	NN
cord-283427-fef9qsik	137	10	and	and	CC
cord-283427-fef9qsik	137	11	the	the	DT
cord-283427-fef9qsik	137	12	canine	canine	JJ
cord-283427-fef9qsik	137	13	vaccine	vaccine	NN
cord-283427-fef9qsik	137	14	is	be	VBZ
cord-283427-fef9qsik	137	15	a	a	DT
cord-283427-fef9qsik	137	16	live	live	JJ
cord-283427-fef9qsik	137	17	-	-	HYPH
cord-283427-fef9qsik	137	18	vaccine	vaccine	NN
cord-283427-fef9qsik	137	19	,	,	,
cord-283427-fef9qsik	137	20	the	the	DT
cord-283427-fef9qsik	137	21	canine	canine	JJ
cord-283427-fef9qsik	137	22	vaccine	vaccine	NN
cord-283427-fef9qsik	137	23	is	be	VBZ
cord-283427-fef9qsik	137	24	more	more	RBR
cord-283427-fef9qsik	137	25	damaging	damaging	JJ
cord-283427-fef9qsik	137	26	to	to	IN
cord-283427-fef9qsik	137	27	BBB	BBB	NNP
cord-283427-fef9qsik	137	28	.	.	.
cord-283427-fef9qsik	138	1	This	this	DT
cord-283427-fef9qsik	138	2	was	be	VBD
cord-283427-fef9qsik	138	3	also	also	RB
cord-283427-fef9qsik	138	4	confirmed	confirm	VBN
cord-283427-fef9qsik	138	5	by	by	IN
cord-283427-fef9qsik	138	6	qPCR	qpcr	NN
cord-283427-fef9qsik	138	7	results	result	NNS
cord-283427-fef9qsik	138	8	of	of	IN
cord-283427-fef9qsik	138	9	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	138	10	mRNA	mrna	NN
cord-283427-fef9qsik	138	11	levels	level	NNS
cord-283427-fef9qsik	138	12	.	.	.
cord-283427-fef9qsik	139	1	As	as	IN
cord-283427-fef9qsik	139	2	expected	expect	VBN
cord-283427-fef9qsik	139	3	,	,	,
cord-283427-fef9qsik	139	4	at	at	IN
cord-283427-fef9qsik	139	5	reference	reference	NN
cord-283427-fef9qsik	139	6	concentration	concentration	NN
cord-283427-fef9qsik	139	7	and	and	CC
cord-283427-fef9qsik	139	8	10-fold	10-fold	JJ
cord-283427-fef9qsik	139	9	diluted	diluted	JJ
cord-283427-fef9qsik	139	10	concentration	concentration	NN
cord-283427-fef9qsik	139	11	of	of	IN
cord-283427-fef9qsik	139	12	stock	stock	NN
cord-283427-fef9qsik	139	13	solution	solution	NN
cord-283427-fef9qsik	139	14	of	of	IN
cord-283427-fef9qsik	139	15	two	two	CD
cord-283427-fef9qsik	139	16	vaccines	vaccine	NNS
cord-283427-fef9qsik	139	17	,	,	,
cord-283427-fef9qsik	139	18	EB	eb	NN
cord-283427-fef9qsik	139	19	dye	dye	NN
cord-283427-fef9qsik	139	20	permeability	permeability	NN
cord-283427-fef9qsik	139	21	and	and	CC
cord-283427-fef9qsik	139	22	relative	relative	JJ
cord-283427-fef9qsik	139	23	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	139	24	and	and	CC
cord-283427-fef9qsik	139	25	occludin	occludin	NNP
cord-283427-fef9qsik	139	26	mRNA	mrna	NN
cord-283427-fef9qsik	139	27	levels	level	NNS
cord-283427-fef9qsik	139	28	were	be	VBD
cord-283427-fef9qsik	139	29	comparable	comparable	JJ
cord-283427-fef9qsik	139	30	to	to	IN
cord-283427-fef9qsik	139	31	those	those	DT
cord-283427-fef9qsik	139	32	of	of	IN
cord-283427-fef9qsik	139	33	the	the	DT
cord-283427-fef9qsik	139	34	negative	negative	JJ
cord-283427-fef9qsik	139	35	control	control	NN
cord-283427-fef9qsik	139	36	,	,	,
cord-283427-fef9qsik	139	37	meaning	mean	VBG
cord-283427-fef9qsik	139	38	no	no	DT
cord-283427-fef9qsik	139	39	significant	significant	JJ
cord-283427-fef9qsik	139	40	damage	damage	NN
cord-283427-fef9qsik	139	41	to	to	IN
cord-283427-fef9qsik	139	42	the	the	DT
cord-283427-fef9qsik	139	43	BBB	BBB	NNP
cord-283427-fef9qsik	139	44	.	.	.
cord-283427-fef9qsik	140	1	Occludin	Occludin	NNP
cord-283427-fef9qsik	140	2	mRNA	mrna	NN
cord-283427-fef9qsik	140	3	expression	expression	NN
cord-283427-fef9qsik	140	4	was	be	VBD
cord-283427-fef9qsik	140	5	lower	low	JJR
cord-283427-fef9qsik	140	6	than	than	IN
cord-283427-fef9qsik	140	7	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	140	8	mRNA	mrna	NN
cord-283427-fef9qsik	140	9	expression	expression	NN
cord-283427-fef9qsik	140	10	level	level	NN
cord-283427-fef9qsik	140	11	at	at	IN
cord-283427-fef9qsik	140	12	2-fold	2-fold	CD
cord-283427-fef9qsik	140	13	diluted	diluted	JJ
cord-283427-fef9qsik	140	14	concentration	concentration	NN
cord-283427-fef9qsik	140	15	of	of	IN
cord-283427-fef9qsik	140	16	the	the	DT
cord-283427-fef9qsik	140	17	stock	stock	NN
cord-283427-fef9qsik	140	18	solution	solution	NN
cord-283427-fef9qsik	140	19	which	which	WDT
cord-283427-fef9qsik	140	20	was	be	VBD
cord-283427-fef9qsik	140	21	considered	consider	VBN
cord-283427-fef9qsik	140	22	to	to	TO
cord-283427-fef9qsik	140	23	be	be	VB
cord-283427-fef9qsik	140	24	damaging	damaging	JJ
cord-283427-fef9qsik	140	25	to	to	IN
cord-283427-fef9qsik	140	26	BBB	BBB	NNP
cord-283427-fef9qsik	140	27	[	[	-LRB-
cord-283427-fef9qsik	140	28	1	1	CD
cord-283427-fef9qsik	140	29	]	]	-RRB-
cord-283427-fef9qsik	140	30	.	.	.
cord-283427-fef9qsik	141	1	We	-PRON-	PRP
cord-283427-fef9qsik	141	2	have	have	VBP
cord-283427-fef9qsik	141	3	previously	previously	RB
cord-283427-fef9qsik	141	4	examined	examine	VBN
cord-283427-fef9qsik	141	5	permeability	permeability	NN
cord-283427-fef9qsik	141	6	of	of	IN
cord-283427-fef9qsik	141	7	EB	EB	NNP
cord-283427-fef9qsik	141	8	dye	dye	NN
cord-283427-fef9qsik	141	9	and	and	CC
cord-283427-fef9qsik	141	10	changes	change	NNS
cord-283427-fef9qsik	141	11	in	in	IN
cord-283427-fef9qsik	141	12	mRNA	mrna	NN
cord-283427-fef9qsik	141	13	and	and	CC
cord-283427-fef9qsik	141	14	protein	protein	NN
cord-283427-fef9qsik	141	15	expression	expression	NN
cord-283427-fef9qsik	141	16	of	of	IN
cord-283427-fef9qsik	141	17	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	141	18	and	and	CC
cord-283427-fef9qsik	141	19	occludin	occludin	NN
cord-283427-fef9qsik	141	20	over	over	IN
cord-283427-fef9qsik	141	21	time	time	NN
cord-283427-fef9qsik	141	22	after	after	IN
cord-283427-fef9qsik	141	23	LPS	LPS	NNP
cord-283427-fef9qsik	141	24	injection	injection	NN
cord-283427-fef9qsik	141	25	.	.	.
cord-283427-fef9qsik	142	1	After	after	IN
cord-283427-fef9qsik	142	2	4	4	CD
cord-283427-fef9qsik	142	3	h	h	NN
cord-283427-fef9qsik	142	4	of	of	IN
cord-283427-fef9qsik	142	5	LPS	LPS	NNP
cord-283427-fef9qsik	142	6	injection	injection	NN
cord-283427-fef9qsik	142	7	,	,	,
cord-283427-fef9qsik	142	8	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	142	9	mRNA	mrna	NN
cord-283427-fef9qsik	142	10	levels	level	NNS
cord-283427-fef9qsik	142	11	were	be	VBD
cord-283427-fef9qsik	142	12	dynamic	dynamic	JJ
cord-283427-fef9qsik	142	13	and	and	CC
cord-283427-fef9qsik	142	14	rapidly	rapidly	RB
cord-283427-fef9qsik	142	15	increased	increase	VBD
cord-283427-fef9qsik	142	16	.	.	.
cord-283427-fef9qsik	143	1	The	the	DT
cord-283427-fef9qsik	143	2	level	level	NN
cord-283427-fef9qsik	143	3	of	of	IN
cord-283427-fef9qsik	143	4	occludin	occludin	NN
cord-283427-fef9qsik	143	5	mRNA	mRNA	NNP
cord-283427-fef9qsik	143	6	increased	increase	VBD
cord-283427-fef9qsik	143	7	after	after	IN
cord-283427-fef9qsik	143	8	4	4	CD
cord-283427-fef9qsik	143	9	h	h	NN
cord-283427-fef9qsik	143	10	of	of	IN
cord-283427-fef9qsik	143	11	injection	injection	NN
cord-283427-fef9qsik	143	12	,	,	,
cord-283427-fef9qsik	143	13	but	but	CC
cord-283427-fef9qsik	143	14	increased	increase	VBD
cord-283427-fef9qsik	143	15	rapidly	rapidly	RB
cord-283427-fef9qsik	143	16	after	after	IN
cord-283427-fef9qsik	143	17	24	24	CD
cord-283427-fef9qsik	143	18	h.	h.	NN
cord-283427-fef9qsik	144	1	These	these	DT
cord-283427-fef9qsik	144	2	results	result	NNS
cord-283427-fef9qsik	144	3	are	be	VBP
cord-283427-fef9qsik	144	4	highly	highly	RB
cord-283427-fef9qsik	144	5	correlated	correlate	VBN
cord-283427-fef9qsik	144	6	with	with	IN
cord-283427-fef9qsik	144	7	our	-PRON-	PRP$
cord-283427-fef9qsik	144	8	previous	previous	JJ
cord-283427-fef9qsik	144	9	findings	finding	NNS
cord-283427-fef9qsik	144	10	.	.	.
cord-283427-fef9qsik	145	1	However	however	RB
cord-283427-fef9qsik	145	2	,	,	,
cord-283427-fef9qsik	145	3	in	in	IN
cord-283427-fef9qsik	145	4	order	order	NN
cord-283427-fef9qsik	145	5	Amount	amount	NN
cord-283427-fef9qsik	145	6	of	of	IN
cord-283427-fef9qsik	145	7	EB	EB	NNP
cord-283427-fef9qsik	145	8	dye	dye	NN
cord-283427-fef9qsik	145	9	after	after	IN
cord-283427-fef9qsik	145	10	canine	canine	JJ
cord-283427-fef9qsik	145	11	parvovirus	parvovirus	NN
cord-283427-fef9qsik	145	12	vaccine	vaccine	NN
cord-283427-fef9qsik	145	13	(	(	-LRB-
cord-283427-fef9qsik	145	14	live	live	JJ
cord-283427-fef9qsik	145	15	-	-	HYPH
cord-283427-fef9qsik	145	16	vaccine	vaccine	NN
cord-283427-fef9qsik	145	17	)	)	-RRB-
cord-283427-fef9qsik	145	18	injection	injection	NN
cord-283427-fef9qsik	145	19	.	.	.
cord-283427-fef9qsik	146	1	The	the	DT
cord-283427-fef9qsik	146	2	permeation	permeation	NN
cord-283427-fef9qsik	146	3	rate	rate	NN
cord-283427-fef9qsik	146	4	of	of	IN
cord-283427-fef9qsik	146	5	EB	EB	NNP
cord-283427-fef9qsik	146	6	dye	dye	NN
cord-283427-fef9qsik	146	7	in	in	IN
cord-283427-fef9qsik	146	8	C1	C1	NNP
cord-283427-fef9qsik	146	9	was	be	VBD
cord-283427-fef9qsik	146	10	higher	high	JJR
cord-283427-fef9qsik	146	11	,	,	,
cord-283427-fef9qsik	146	12	but	but	CC
cord-283427-fef9qsik	146	13	not	not	RB
cord-283427-fef9qsik	146	14	significantly	significantly	RB
cord-283427-fef9qsik	146	15	higher	high	JJR
cord-283427-fef9qsik	146	16	than	than	IN
cord-283427-fef9qsik	146	17	that	that	DT
cord-283427-fef9qsik	146	18	in	in	IN
cord-283427-fef9qsik	146	19	LPS	LPS	NNP
cord-283427-fef9qsik	146	20	/	/	SYM
cord-283427-fef9qsik	146	21	EB	EB	NNP
cord-283427-fef9qsik	146	22	group	group	NN
cord-283427-fef9qsik	147	1	(	(	-LRB-
cord-283427-fef9qsik	147	2	*	*	NFP
cord-283427-fef9qsik	147	3	,	,	,
cord-283427-fef9qsik	147	4	P	p	NN
cord-283427-fef9qsik	147	5	<	<	XX
cord-283427-fef9qsik	147	6	0.05	0.05	CD
cord-283427-fef9qsik	147	7	;	;	:
cord-283427-fef9qsik	147	8	*	*	NFP
cord-283427-fef9qsik	147	9	*	*	NFP
cord-283427-fef9qsik	147	10	,	,	,
cord-283427-fef9qsik	147	11	P	p	NN
cord-283427-fef9qsik	147	12	<	<	XX
cord-283427-fef9qsik	147	13	0.01	0.01	CD
cord-283427-fef9qsik	147	14	;	;	:
cord-283427-fef9qsik	148	1	*	*	NFP
cord-283427-fef9qsik	148	2	*	*	NFP
cord-283427-fef9qsik	148	3	*	*	NFP
cord-283427-fef9qsik	148	4	,	,	,
cord-283427-fef9qsik	148	5	P	p	NN
cord-283427-fef9qsik	148	6	<	<	XX
cord-283427-fef9qsik	148	7	0.005	0.005	XX
cord-283427-fef9qsik	148	8	)	)	-RRB-
cord-283427-fef9qsik	148	9	to	to	TO
cord-283427-fef9qsik	148	10	provide	provide	VB
cord-283427-fef9qsik	148	11	a	a	DT
cord-283427-fef9qsik	148	12	rapid	rapid	JJ
cord-283427-fef9qsik	148	13	supply	supply	NN
cord-283427-fef9qsik	148	14	of	of	IN
cord-283427-fef9qsik	148	15	urgent	urgent	JJ
cord-283427-fef9qsik	148	16	vaccines	vaccine	NNS
cord-283427-fef9qsik	148	17	,	,	,
cord-283427-fef9qsik	148	18	rapid	rapid	JJ
cord-283427-fef9qsik	148	19	verification	verification	NN
cord-283427-fef9qsik	148	20	is	be	VBZ
cord-283427-fef9qsik	148	21	required	require	VBN
cord-283427-fef9qsik	148	22	.	.	.
cord-283427-fef9qsik	149	1	Considering	consider	VBG
cord-283427-fef9qsik	149	2	this	this	DT
cord-283427-fef9qsik	149	3	,	,	,
cord-283427-fef9qsik	149	4	4	4	CD
cord-283427-fef9qsik	149	5	h	h	NN
cord-283427-fef9qsik	149	6	after	after	IN
cord-283427-fef9qsik	149	7	injection	injection	NN
cord-283427-fef9qsik	149	8	of	of	IN
cord-283427-fef9qsik	149	9	LPS	LPS	NNP
cord-283427-fef9qsik	149	10	was	be	VBD
cord-283427-fef9qsik	149	11	established	establish	VBN
cord-283427-fef9qsik	149	12	as	as	IN
cord-283427-fef9qsik	149	13	a	a	DT
cord-283427-fef9qsik	149	14	positive	positive	JJ
cord-283427-fef9qsik	149	15	control	control	NN
cord-283427-fef9qsik	149	16	condition	condition	NN
cord-283427-fef9qsik	149	17	of	of	IN
cord-283427-fef9qsik	149	18	the	the	DT
cord-283427-fef9qsik	149	19	module	module	NN
cord-283427-fef9qsik	149	20	for	for	IN
cord-283427-fef9qsik	149	21	evaluating	evaluate	VBG
cord-283427-fef9qsik	149	22	BBB	BBB	NNP
cord-283427-fef9qsik	149	23	damage	damage	NN
cord-283427-fef9qsik	149	24	.	.	.
cord-283427-fef9qsik	150	1	Consistent	consistent	JJ
cord-283427-fef9qsik	150	2	with	with	IN
cord-283427-fef9qsik	150	3	results	result	NNS
cord-283427-fef9qsik	150	4	of	of	IN
cord-283427-fef9qsik	150	5	previous	previous	JJ
cord-283427-fef9qsik	150	6	studies	study	NNS
cord-283427-fef9qsik	150	7	,	,	,
cord-283427-fef9qsik	150	8	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	150	9	levels	level	NNS
cord-283427-fef9qsik	150	10	,	,	,
cord-283427-fef9qsik	150	11	but	but	CC
cord-283427-fef9qsik	150	12	not	not	RB
cord-283427-fef9qsik	150	13	occludin	occludin	JJ
cord-283427-fef9qsik	150	14	levels	level	NNS
cord-283427-fef9qsik	150	15	,	,	,
cord-283427-fef9qsik	150	16	were	be	VBD
cord-283427-fef9qsik	150	17	increased	increase	VBN
cord-283427-fef9qsik	150	18	rapidly	rapidly	RB
cord-283427-fef9qsik	150	19	after	after	IN
cord-283427-fef9qsik	150	20	4	4	CD
cord-283427-fef9qsik	150	21	h	h	NN
cord-283427-fef9qsik	150	22	of	of	IN
cord-283427-fef9qsik	150	23	vaccine	vaccine	NN
cord-283427-fef9qsik	150	24	injection	injection	NN
cord-283427-fef9qsik	150	25	.	.	.
cord-283427-fef9qsik	151	1	Therefore	therefore	RB
cord-283427-fef9qsik	151	2	,	,	,
cord-283427-fef9qsik	151	3	when	when	WRB
cord-283427-fef9qsik	151	4	a	a	DT
cord-283427-fef9qsik	151	5	commercially	commercially	RB
cord-283427-fef9qsik	151	6	available	available	JJ
cord-283427-fef9qsik	151	7	vaccine	vaccine	NN
cord-283427-fef9qsik	151	8	is	be	VBZ
cord-283427-fef9qsik	151	9	applied	apply	VBN
cord-283427-fef9qsik	151	10	to	to	IN
cord-283427-fef9qsik	151	11	our	-PRON-	PRP$
cord-283427-fef9qsik	151	12	positive	positive	JJ
cord-283427-fef9qsik	151	13	control	control	NN
cord-283427-fef9qsik	151	14	and	and	CC
cord-283427-fef9qsik	151	15	rapid	rapid	JJ
cord-283427-fef9qsik	151	16	safety	safety	NN
cord-283427-fef9qsik	151	17	assay	assay	NN
cord-283427-fef9qsik	151	18	modules	module	NNS
cord-283427-fef9qsik	151	19	,	,	,
cord-283427-fef9qsik	151	20	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	152	1	tight	tight	JJ
cord-283427-fef9qsik	152	2	junction	junction	NN
cord-283427-fef9qsik	152	3	primer	primer	NN
cord-283427-fef9qsik	152	4	is	be	VBZ
cord-283427-fef9qsik	152	5	more	more	RBR
cord-283427-fef9qsik	152	6	suitable	suitable	JJ
cord-283427-fef9qsik	152	7	for	for	IN
cord-283427-fef9qsik	152	8	qPCR	qPCR	NNP
cord-283427-fef9qsik	152	9	.	.	.
cord-283427-fef9qsik	153	1	In	in	IN
cord-283427-fef9qsik	153	2	addition	addition	NN
cord-283427-fef9qsik	153	3	,	,	,
cord-283427-fef9qsik	153	4	we	-PRON-	PRP
cord-283427-fef9qsik	153	5	have	have	VBP
cord-283427-fef9qsik	153	6	purposed	purpose	VBN
cord-283427-fef9qsik	153	7	three	three	CD
cord-283427-fef9qsik	153	8	assays	assay	NNS
cord-283427-fef9qsik	153	9	of	of	IN
cord-283427-fef9qsik	153	10	EB	EB	NNP
cord-283427-fef9qsik	153	11	assay	assay	NN
cord-283427-fef9qsik	153	12	,	,	,
cord-283427-fef9qsik	153	13	qPCR	qPCR	NNP
cord-283427-fef9qsik	153	14	,	,	,
cord-283427-fef9qsik	153	15	and	and	CC
cord-283427-fef9qsik	153	16	western	western	JJ
cord-283427-fef9qsik	153	17	blot	blot	NN
cord-283427-fef9qsik	153	18	as	as	IN
cord-283427-fef9qsik	153	19	methods	method	NNS
cord-283427-fef9qsik	153	20	to	to	TO
cord-283427-fef9qsik	153	21	determine	determine	VB
cord-283427-fef9qsik	153	22	damage	damage	NN
cord-283427-fef9qsik	153	23	to	to	IN
cord-283427-fef9qsik	153	24	BBB	BBB	NNP
cord-283427-fef9qsik	153	25	in	in	IN
cord-283427-fef9qsik	153	26	our	-PRON-	PRP$
cord-283427-fef9qsik	153	27	previous	previous	JJ
cord-283427-fef9qsik	153	28	study	study	NN
cord-283427-fef9qsik	153	29	[	[	-LRB-
cord-283427-fef9qsik	153	30	1	1	CD
cord-283427-fef9qsik	153	31	]	]	-RRB-
cord-283427-fef9qsik	153	32	.	.	.
cord-283427-fef9qsik	154	1	However	however	RB
cord-283427-fef9qsik	154	2	,	,	,
cord-283427-fef9qsik	154	3	since	since	IN
cord-283427-fef9qsik	154	4	this	this	DT
cord-283427-fef9qsik	154	5	module	module	NN
cord-283427-fef9qsik	154	6	is	be	VBZ
cord-283427-fef9qsik	154	7	aimed	aim	VBN
cord-283427-fef9qsik	154	8	at	at	IN
cord-283427-fef9qsik	154	9	assessing	assess	VBG
cord-283427-fef9qsik	154	10	the	the	DT
cord-283427-fef9qsik	154	11	safety	safety	NN
cord-283427-fef9qsik	154	12	of	of	IN
cord-283427-fef9qsik	154	13	urgent	urgent	JJ
cord-283427-fef9qsik	154	14	vaccines	vaccine	NNS
cord-283427-fef9qsik	154	15	,	,	,
cord-283427-fef9qsik	154	16	western	western	JJ
cord-283427-fef9qsik	154	17	blot	blot	NN
cord-283427-fef9qsik	154	18	analysis	analysis	NN
cord-283427-fef9qsik	154	19	which	which	WDT
cord-283427-fef9qsik	154	20	requires	require	VBZ
cord-283427-fef9qsik	154	21	a	a	DT
cord-283427-fef9qsik	154	22	relatively	relatively	RB
cord-283427-fef9qsik	154	23	long	long	JJ
cord-283427-fef9qsik	154	24	time	time	NN
cord-283427-fef9qsik	154	25	might	may	MD
cord-283427-fef9qsik	154	26	not	not	RB
cord-283427-fef9qsik	154	27	be	be	VB
cord-283427-fef9qsik	154	28	suitable	suitable	JJ
cord-283427-fef9qsik	154	29	.	.	.
cord-283427-fef9qsik	155	1	Therefore	therefore	RB
cord-283427-fef9qsik	155	2	,	,	,
cord-283427-fef9qsik	155	3	EB	EB	NNP
cord-283427-fef9qsik	155	4	assay	assay	NN
cord-283427-fef9qsik	155	5	and	and	CC
cord-283427-fef9qsik	155	6	qPCR	qpcr	NN
cord-283427-fef9qsik	155	7	would	would	MD
cord-283427-fef9qsik	155	8	be	be	VB
cord-283427-fef9qsik	155	9	more	more	RBR
cord-283427-fef9qsik	155	10	effective	effective	JJ
cord-283427-fef9qsik	155	11	methods	method	NNS
cord-283427-fef9qsik	155	12	for	for	IN
cord-283427-fef9qsik	155	13	rapid	rapid	JJ
cord-283427-fef9qsik	155	14	evaluation	evaluation	NN
cord-283427-fef9qsik	155	15	.	.	.
cord-283427-fef9qsik	156	1	It	-PRON-	PRP
cord-283427-fef9qsik	156	2	is	be	VBZ
cord-283427-fef9qsik	156	3	recommended	recommend	VBN
cord-283427-fef9qsik	156	4	that	that	IN
cord-283427-fef9qsik	156	5	we	-PRON-	PRP
cord-283427-fef9qsik	156	6	refer	refer	VBP
cord-283427-fef9qsik	156	7	to	to	IN
cord-283427-fef9qsik	156	8	an	an	DT
cord-283427-fef9qsik	156	9	illustration	illustration	NN
cord-283427-fef9qsik	156	10	of	of	IN
cord-283427-fef9qsik	156	11	our	-PRON-	PRP$
cord-283427-fef9qsik	156	12	research	research	NN
cord-283427-fef9qsik	156	13	process	process	NN
cord-283427-fef9qsik	156	14	on	on	IN
cord-283427-fef9qsik	156	15	the	the	DT
cord-283427-fef9qsik	156	16	safety	safety	NN
cord-283427-fef9qsik	156	17	assessment	assessment	NN
cord-283427-fef9qsik	156	18	of	of	IN
cord-283427-fef9qsik	156	19	vaccines	vaccine	NNS
cord-283427-fef9qsik	156	20	(	(	-LRB-
cord-283427-fef9qsik	156	21	Fig	Fig	NNP
cord-283427-fef9qsik	156	22	.	.	.
cord-283427-fef9qsik	156	23	3	3	CD
cord-283427-fef9qsik	156	24	)	)	-RRB-
cord-283427-fef9qsik	156	25	.	.	.
cord-283427-fef9qsik	157	1	In	in	IN
cord-283427-fef9qsik	157	2	this	this	DT
cord-283427-fef9qsik	157	3	study	study	NN
cord-283427-fef9qsik	157	4	,	,	,
cord-283427-fef9qsik	157	5	we	-PRON-	PRP
cord-283427-fef9qsik	157	6	confirmed	confirm	VBD
cord-283427-fef9qsik	157	7	that	that	IN
cord-283427-fef9qsik	157	8	the	the	DT
cord-283427-fef9qsik	157	9	safety	safety	NN
cord-283427-fef9qsik	157	10	assessment	assessment	NN
cord-283427-fef9qsik	157	11	module	module	NN
cord-283427-fef9qsik	157	12	for	for	IN
cord-283427-fef9qsik	157	13	urgent	urgent	JJ
cord-283427-fef9qsik	157	14	vaccines	vaccine	NNS
cord-283427-fef9qsik	157	15	could	could	MD
cord-283427-fef9qsik	157	16	be	be	VB
cord-283427-fef9qsik	157	17	used	use	VBN
cord-283427-fef9qsik	157	18	to	to	TO
cord-283427-fef9qsik	157	19	evaluate	evaluate	VB
cord-283427-fef9qsik	157	20	two	two	CD
cord-283427-fef9qsik	157	21	commercial	commercial	JJ
cord-283427-fef9qsik	157	22	vaccines	vaccine	NNS
cord-283427-fef9qsik	157	23	.	.	.
cord-283427-fef9qsik	158	1	However	however	RB
cord-283427-fef9qsik	158	2	,	,	,
cord-283427-fef9qsik	158	3	in	in	IN
cord-283427-fef9qsik	158	4	order	order	NN
cord-283427-fef9qsik	158	5	for	for	IN
cord-283427-fef9qsik	158	6	this	this	DT
cord-283427-fef9qsik	158	7	module	module	NN
cord-283427-fef9qsik	158	8	to	to	TO
cord-283427-fef9qsik	158	9	be	be	VB
cord-283427-fef9qsik	158	10	used	use	VBN
cord-283427-fef9qsik	158	11	in	in	IN
cord-283427-fef9qsik	158	12	practice	practice	NN
cord-283427-fef9qsik	158	13	,	,	,
cord-283427-fef9qsik	158	14	it	-PRON-	PRP
cord-283427-fef9qsik	158	15	is	be	VBZ
cord-283427-fef9qsik	158	16	necessary	necessary	JJ
cord-283427-fef9qsik	158	17	to	to	TO
cord-283427-fef9qsik	158	18	apply	apply	VB
cord-283427-fef9qsik	158	19	more	more	JJR
cord-283427-fef9qsik	158	20	types	type	NNS
cord-283427-fef9qsik	158	21	of	of	IN
cord-283427-fef9qsik	158	22	vaccines	vaccine	NNS
cord-283427-fef9qsik	158	23	to	to	IN
cord-283427-fef9qsik	158	24	the	the	DT
cord-283427-fef9qsik	158	25	module	module	NN
cord-283427-fef9qsik	158	26	.	.	.
cord-283427-fef9qsik	159	1	Since	since	IN
cord-283427-fef9qsik	159	2	there	there	EX
cord-283427-fef9qsik	159	3	are	be	VBP
cord-283427-fef9qsik	159	4	many	many	JJ
cord-283427-fef9qsik	159	5	kinds	kind	NNS
cord-283427-fef9qsik	159	6	of	of	IN
cord-283427-fef9qsik	159	7	vaccines	vaccine	NNS
cord-283427-fef9qsik	159	8	,	,	,
cord-283427-fef9qsik	159	9	they	-PRON-	PRP
cord-283427-fef9qsik	159	10	should	should	MD
cord-283427-fef9qsik	159	11	be	be	VB
cord-283427-fef9qsik	159	12	repeatedly	repeatedly	RB
cord-283427-fef9qsik	159	13	applied	apply	VBN
cord-283427-fef9qsik	159	14	and	and	CC
cord-283427-fef9qsik	159	15	evaluated	evaluate	VBD
cord-283427-fef9qsik	159	16	using	use	VBG
cord-283427-fef9qsik	159	17	this	this	DT
cord-283427-fef9qsik	159	18	module	module	NN
cord-283427-fef9qsik	159	19	.	.	.
cord-283427-fef9qsik	160	1	Taken	take	VBN
cord-283427-fef9qsik	160	2	together	together	RB
cord-283427-fef9qsik	160	3	,	,	,
cord-283427-fef9qsik	160	4	the	the	DT
cord-283427-fef9qsik	160	5	usefulness	usefulness	NN
cord-283427-fef9qsik	160	6	of	of	IN
cord-283427-fef9qsik	160	7	the	the	DT
cord-283427-fef9qsik	160	8	rapid	rapid	JJ
cord-283427-fef9qsik	160	9	brain	brain	NN
cord-283427-fef9qsik	160	10	safety	safety	NN
cord-283427-fef9qsik	160	11	test	test	NN
cord-283427-fef9qsik	160	12	module	module	NN
cord-283427-fef9qsik	160	13	that	that	WDT
cord-283427-fef9qsik	160	14	we	-PRON-	PRP
cord-283427-fef9qsik	160	15	constructed	construct	VBD
cord-283427-fef9qsik	160	16	previously	previously	RB
cord-283427-fef9qsik	160	17	was	be	VBD
cord-283427-fef9qsik	160	18	verified	verify	VBN
cord-283427-fef9qsik	160	19	using	use	VBG
cord-283427-fef9qsik	160	20	vaccines	vaccine	NNS
cord-283427-fef9qsik	160	21	Fig	Fig	NNP
cord-283427-fef9qsik	160	22	.	.	.
cord-283427-fef9qsik	161	1	2	2	LS
cord-283427-fef9qsik	161	2	Quantification	quantification	NN
cord-283427-fef9qsik	161	3	of	of	IN
cord-283427-fef9qsik	161	4	mRNA	mRNA	NNP
cord-283427-fef9qsik	161	5	levels	level	NNS
cord-283427-fef9qsik	161	6	of	of	IN
cord-283427-fef9qsik	161	7	zonula	zonula	NN
cord-283427-fef9qsik	161	8	occludens-1	occludens-1	NNP
cord-283427-fef9qsik	161	9	(	(	-LRB-
cord-283427-fef9qsik	161	10	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	161	11	)	)	-RRB-
cord-283427-fef9qsik	161	12	and	and	CC
cord-283427-fef9qsik	161	13	occludin	occludin	NN
cord-283427-fef9qsik	161	14	in	in	IN
cord-283427-fef9qsik	161	15	mouse	mouse	NN
cord-283427-fef9qsik	161	16	brains	brain	NNS
cord-283427-fef9qsik	161	17	.	.	.
cord-283427-fef9qsik	162	1	BBB	BBB	NNP
cord-283427-fef9qsik	162	2	breakdown	breakdown	NN
cord-283427-fef9qsik	162	3	and	and	CC
cord-283427-fef9qsik	162	4	restoration	restoration	NN
cord-283427-fef9qsik	162	5	were	be	VBD
cord-283427-fef9qsik	162	6	confirmed	confirm	VBN
cord-283427-fef9qsik	162	7	through	through	IN
cord-283427-fef9qsik	162	8	expression	expression	NN
cord-283427-fef9qsik	162	9	level	level	NN
cord-283427-fef9qsik	162	10	analysis	analysis	NN
cord-283427-fef9qsik	162	11	of	of	IN
cord-283427-fef9qsik	162	12	tight	tight	JJ
cord-283427-fef9qsik	162	13	junctions	junction	NNS
cord-283427-fef9qsik	162	14	in	in	IN
cord-283427-fef9qsik	162	15	BBB	BBB	NNP
cord-283427-fef9qsik	162	16	.	.	.
cord-283427-fef9qsik	163	1	a	a	DT
cord-283427-fef9qsik	163	2	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	163	3	mRNA	mrna	NN
cord-283427-fef9qsik	163	4	expression	expression	NN
cord-283427-fef9qsik	163	5	after	after	IN
cord-283427-fef9qsik	163	6	porcine	porcine	JJ
cord-283427-fef9qsik	163	7	genital	genital	JJ
cord-283427-fef9qsik	163	8	respiratory	respiratory	JJ
cord-283427-fef9qsik	163	9	syndrome	syndrome	NN
cord-283427-fef9qsik	163	10	vaccine	vaccine	NN
cord-283427-fef9qsik	163	11	(	(	-LRB-
cord-283427-fef9qsik	163	12	killedvaccine	killedvaccine	NNP
cord-283427-fef9qsik	163	13	)	)	-RRB-
cord-283427-fef9qsik	163	14	injection	injection	NN
cord-283427-fef9qsik	163	15	.	.	.
cord-283427-fef9qsik	164	1	b	b	LS
cord-283427-fef9qsik	164	2	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	164	3	mRNA	mrna	NN
cord-283427-fef9qsik	164	4	expression	expression	NN
cord-283427-fef9qsik	164	5	after	after	IN
cord-283427-fef9qsik	164	6	canine	canine	JJ
cord-283427-fef9qsik	164	7	parvovirus	parvovirus	NN
cord-283427-fef9qsik	164	8	vaccine	vaccine	NN
cord-283427-fef9qsik	164	9	(	(	-LRB-
cord-283427-fef9qsik	164	10	live	live	JJ
cord-283427-fef9qsik	164	11	-	-	HYPH
cord-283427-fef9qsik	164	12	vaccine	vaccine	NN
cord-283427-fef9qsik	164	13	)	)	-RRB-
cord-283427-fef9qsik	164	14	injection	injection	NN
cord-283427-fef9qsik	164	15	.	.	.
cord-283427-fef9qsik	165	1	c	c	NNP
cord-283427-fef9qsik	166	1	Occludin	Occludin	NNP
cord-283427-fef9qsik	166	2	mRNA	mrna	NN
cord-283427-fef9qsik	166	3	expression	expression	NN
cord-283427-fef9qsik	166	4	after	after	IN
cord-283427-fef9qsik	166	5	porcine	porcine	JJ
cord-283427-fef9qsik	166	6	genital	genital	JJ
cord-283427-fef9qsik	166	7	respiratory	respiratory	JJ
cord-283427-fef9qsik	166	8	syndrome	syndrome	NN
cord-283427-fef9qsik	166	9	vaccine	vaccine	NN
cord-283427-fef9qsik	166	10	(	(	-LRB-
cord-283427-fef9qsik	166	11	killed	kill	VBN
cord-283427-fef9qsik	166	12	-	-	HYPH
cord-283427-fef9qsik	166	13	vaccine	vaccine	NN
cord-283427-fef9qsik	166	14	)	)	-RRB-
cord-283427-fef9qsik	166	15	injection	injection	NN
cord-283427-fef9qsik	166	16	.	.	.
cord-283427-fef9qsik	167	1	d	d	NNP
cord-283427-fef9qsik	167	2	Occludin	Occludin	NNP
cord-283427-fef9qsik	167	3	mRNA	mrna	NN
cord-283427-fef9qsik	167	4	expression	expression	NN
cord-283427-fef9qsik	167	5	after	after	IN
cord-283427-fef9qsik	167	6	canine	canine	JJ
cord-283427-fef9qsik	167	7	parvovirus	parvovirus	NN
cord-283427-fef9qsik	167	8	vaccine	vaccine	NN
cord-283427-fef9qsik	167	9	(	(	-LRB-
cord-283427-fef9qsik	167	10	live	live	JJ
cord-283427-fef9qsik	167	11	-	-	HYPH
cord-283427-fef9qsik	167	12	vaccine	vaccine	NN
cord-283427-fef9qsik	167	13	)	)	-RRB-
cord-283427-fef9qsik	167	14	injection	injection	NN
cord-283427-fef9qsik	167	15	(	(	-LRB-
cord-283427-fef9qsik	167	16	*	*	NFP
cord-283427-fef9qsik	167	17	,	,	,
cord-283427-fef9qsik	167	18	P	p	NN
cord-283427-fef9qsik	167	19	<	<	XX
cord-283427-fef9qsik	167	20	0.05	0.05	CD
cord-283427-fef9qsik	167	21	;	;	.
cord-283427-fef9qsik	168	1	*	*	NFP
cord-283427-fef9qsik	168	2	*	*	NFP
cord-283427-fef9qsik	168	3	,	,	,
cord-283427-fef9qsik	168	4	P	p	NN
cord-283427-fef9qsik	168	5	<	<	XX
cord-283427-fef9qsik	168	6	0.01	0.01	CD
cord-283427-fef9qsik	168	7	)	)	-RRB-
cord-283427-fef9qsik	168	8	commercially	commercially	RB
cord-283427-fef9qsik	168	9	available	available	JJ
cord-283427-fef9qsik	168	10	in	in	IN
cord-283427-fef9qsik	168	11	the	the	DT
cord-283427-fef9qsik	168	12	veterinary	veterinary	JJ
cord-283427-fef9qsik	168	13	market	market	NN
cord-283427-fef9qsik	168	14	in	in	IN
cord-283427-fef9qsik	168	15	Korea	Korea	NNP
cord-283427-fef9qsik	168	16	.	.	.
cord-283427-fef9qsik	169	1	Our	-PRON-	PRP$
cord-283427-fef9qsik	169	2	results	result	NNS
cord-283427-fef9qsik	169	3	were	be	VBD
cord-283427-fef9qsik	169	4	highly	highly	RB
cord-283427-fef9qsik	169	5	reproducible	reproducible	JJ
cord-283427-fef9qsik	169	6	.	.	.
cord-283427-fef9qsik	170	1	Therefore	therefore	RB
cord-283427-fef9qsik	170	2	,	,	,
cord-283427-fef9qsik	170	3	this	this	DT
cord-283427-fef9qsik	170	4	evaluation	evaluation	NN
cord-283427-fef9qsik	170	5	module	module	NN
cord-283427-fef9qsik	170	6	can	can	MD
cord-283427-fef9qsik	170	7	be	be	VB
cord-283427-fef9qsik	170	8	utilized	utilize	VBN
cord-283427-fef9qsik	170	9	in	in	IN
cord-283427-fef9qsik	170	10	the	the	DT
cord-283427-fef9qsik	170	11	future	future	NN
cord-283427-fef9qsik	170	12	to	to	TO
cord-283427-fef9qsik	170	13	assess	assess	VB
cord-283427-fef9qsik	170	14	the	the	DT
cord-283427-fef9qsik	170	15	safety	safety	NN
cord-283427-fef9qsik	170	16	of	of	IN
cord-283427-fef9qsik	170	17	various	various	JJ
cord-283427-fef9qsik	170	18	vaccines	vaccine	NNS
cord-283427-fef9qsik	170	19	and	and	CC
cord-283427-fef9qsik	170	20	adjuvants	adjuvant	NNS
cord-283427-fef9qsik	170	21	.	.	.
cord-283427-fef9qsik	171	1	Fig	Fig	NNP
cord-283427-fef9qsik	171	2	.	.	.
cord-283427-fef9qsik	172	1	3	3	LS
cord-283427-fef9qsik	173	1	It	-PRON-	PRP
cord-283427-fef9qsik	173	2	is	be	VBZ
cord-283427-fef9qsik	173	3	a	a	DT
cord-283427-fef9qsik	173	4	safety	safety	NN
cord-283427-fef9qsik	173	5	evaluation	evaluation	NN
cord-283427-fef9qsik	173	6	method	method	NN
cord-283427-fef9qsik	173	7	of	of	IN
cord-283427-fef9qsik	173	8	vaccine	vaccine	NN
cord-283427-fef9qsik	173	9	against	against	IN
cord-283427-fef9qsik	173	10	pre	pre	JJ
cord-283427-fef9qsik	173	11	-	-	JJ
cord-283427-fef9qsik	173	12	established	established	JJ
cord-283427-fef9qsik	173	13	brain	brain	NN
cord-283427-fef9qsik	173	14	parenchyma	parenchyma	NN
cord-283427-fef9qsik	173	15	.	.	.
cord-283427-fef9qsik	174	1	Based	base	VBN
cord-283427-fef9qsik	174	2	on	on	IN
cord-283427-fef9qsik	174	3	the	the	DT
cord-283427-fef9qsik	174	4	results	result	NNS
cord-283427-fef9qsik	174	5	of	of	IN
cord-283427-fef9qsik	174	6	our	-PRON-	PRP$
cord-283427-fef9qsik	174	7	established	establish	VBN
cord-283427-fef9qsik	174	8	experimental	experimental	JJ
cord-283427-fef9qsik	174	9	conditions	condition	NNS
cord-283427-fef9qsik	174	10	according	accord	VBG
cord-283427-fef9qsik	174	11	to	to	IN
cord-283427-fef9qsik	174	12	Baek	Baek	NNP
cord-283427-fef9qsik	174	13	et	et	NNP
cord-283427-fef9qsik	174	14	al	al	NNP
cord-283427-fef9qsik	174	15	.	.	.
cord-283427-fef9qsik	175	1	[	[	-LRB-
cord-283427-fef9qsik	175	2	1	1	CD
cord-283427-fef9qsik	175	3	]	]	-RRB-
cord-283427-fef9qsik	175	4	,	,	,
cord-283427-fef9qsik	175	5	LPS	LPS	NNP
cord-283427-fef9qsik	175	6	(	(	-LRB-
cord-283427-fef9qsik	175	7	S.	S.	NNP
cord-283427-fef9qsik	175	8	enterica	enterica	NN
cord-283427-fef9qsik	175	9	-	-	HYPH
cord-283427-fef9qsik	175	10	derived	derive	VBN
cord-283427-fef9qsik	175	11	)	)	-RRB-
cord-283427-fef9qsik	175	12	and	and	CC
cord-283427-fef9qsik	175	13	commercially	commercially	RB
cord-283427-fef9qsik	175	14	available	available	JJ
cord-283427-fef9qsik	175	15	vaccines	vaccine	NNS
cord-283427-fef9qsik	175	16	are	be	VBP
cord-283427-fef9qsik	175	17	injected	inject	VBN
cord-283427-fef9qsik	175	18	intraperitoneally	intraperitoneally	RB
cord-283427-fef9qsik	175	19	into	into	IN
cord-283427-fef9qsik	175	20	7-week	7-week	JJ
cord-283427-fef9qsik	175	21	-	-	HYPH
cord-283427-fef9qsik	175	22	old	old	JJ
cord-283427-fef9qsik	175	23	ICR	ICR	NNP
cord-283427-fef9qsik	175	24	mice	mouse	NNS
cord-283427-fef9qsik	175	25	(	(	-LRB-
cord-283427-fef9qsik	175	26	1.0	1.0	CD
cord-283427-fef9qsik	175	27	mg	mg	NNP
cord-283427-fef9qsik	175	28	LPS/4	LPS/4	NNP
cord-283427-fef9qsik	175	29	ml	ml	NNP
cord-283427-fef9qsik	175	30	/	/	SYM
cord-283427-fef9qsik	175	31	kg	kg	NNP
cord-283427-fef9qsik	175	32	)	)	-RRB-
cord-283427-fef9qsik	175	33	and	and	CC
cord-283427-fef9qsik	175	34	brain	brain	NN
cord-283427-fef9qsik	175	35	hemispheres	hemisphere	NNS
cord-283427-fef9qsik	175	36	were	be	VBD
cord-283427-fef9qsik	175	37	removed	remove	VBN
cord-283427-fef9qsik	175	38	after	after	IN
cord-283427-fef9qsik	175	39	4	4	CD
cord-283427-fef9qsik	175	40	h	h	NN
cord-283427-fef9qsik	175	41	post	post	NN
cord-283427-fef9qsik	175	42	-	-	NN
cord-283427-fef9qsik	175	43	injection	injection	NN
cord-283427-fef9qsik	175	44	.	.	.
cord-283427-fef9qsik	176	1	The	the	DT
cord-283427-fef9qsik	176	2	mRNA	mrna	NN
cord-283427-fef9qsik	176	3	is	be	VBZ
cord-283427-fef9qsik	176	4	extracted	extract	VBN
cord-283427-fef9qsik	176	5	from	from	IN
cord-283427-fef9qsik	176	6	the	the	DT
cord-283427-fef9qsik	176	7	brain	brain	NN
cord-283427-fef9qsik	176	8	,	,	,
cord-283427-fef9qsik	176	9	and	and	CC
cord-283427-fef9qsik	176	10	sequentially	sequentially	RB
cord-283427-fef9qsik	176	11	performed	perform	VBD
cord-283427-fef9qsik	176	12	real	real	JJ
cord-283427-fef9qsik	176	13	time	time	NN
cord-283427-fef9qsik	176	14	PCR	PCR	NNP
cord-283427-fef9qsik	176	15	(	(	-LRB-
cord-283427-fef9qsik	176	16	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	176	17	and	and	CC
cord-283427-fef9qsik	176	18	occluding	occlude	VBG
cord-283427-fef9qsik	176	19	)	)	-RRB-
cord-283427-fef9qsik	176	20	.	.	.
cord-283427-fef9qsik	177	1	The	the	DT
cord-283427-fef9qsik	177	2	tight	tight	JJ
cord-283427-fef9qsik	177	3	junction	junction	NN
cord-283427-fef9qsik	177	4	mRNA	mrna	NN
cord-283427-fef9qsik	177	5	levels	level	NNS
cord-283427-fef9qsik	177	6	of	of	IN
cord-283427-fef9qsik	177	7	the	the	DT
cord-283427-fef9qsik	177	8	vaccine	vaccine	NN
cord-283427-fef9qsik	177	9	-	-	HYPH
cord-283427-fef9qsik	177	10	treated	treat	VBN
cord-283427-fef9qsik	177	11	group	group	NN
cord-283427-fef9qsik	177	12	with	with	IN
cord-283427-fef9qsik	177	13	those	those	DT
cord-283427-fef9qsik	177	14	of	of	IN
cord-283427-fef9qsik	177	15	the	the	DT
cord-283427-fef9qsik	177	16	LPStreated	lpstreate	VBN
cord-283427-fef9qsik	177	17	group	group	NN
cord-283427-fef9qsik	177	18	were	be	VBD
cord-283427-fef9qsik	177	19	compared	compare	VBN
cord-283427-fef9qsik	177	20	and	and	CC
cord-283427-fef9qsik	177	21	potential	potential	JJ
cord-283427-fef9qsik	177	22	risk	risk	NN
cord-283427-fef9qsik	177	23	to	to	IN
cord-283427-fef9qsik	177	24	the	the	DT
cord-283427-fef9qsik	177	25	BBB	BBB	NNP
cord-283427-fef9qsik	177	26	of	of	IN
cord-283427-fef9qsik	177	27	the	the	DT
cord-283427-fef9qsik	177	28	vaccine	vaccine	NN
cord-283427-fef9qsik	177	29	is	be	VBZ
cord-283427-fef9qsik	177	30	evaluated	evaluate	VBN
cord-283427-fef9qsik	177	31	.	.	.
cord-283427-fef9qsik	178	1	(	(	-LRB-
cord-283427-fef9qsik	178	2	This	this	DT
cord-283427-fef9qsik	178	3	conceptual	conceptual	JJ
cord-283427-fef9qsik	178	4	diagram	diagram	NN
cord-283427-fef9qsik	178	5	is	be	VBZ
cord-283427-fef9qsik	178	6	shown	show	VBN
cord-283427-fef9qsik	178	7	by	by	IN
cord-283427-fef9qsik	178	8	applying	apply	VBG
cord-283427-fef9qsik	178	9	the	the	DT
cord-283427-fef9qsik	178	10	method	method	NN
cord-283427-fef9qsik	178	11	used	use	VBN
cord-283427-fef9qsik	178	12	by	by	IN
cord-283427-fef9qsik	178	13	Baek	Baek	NNP
cord-283427-fef9qsik	178	14	et	et	NNP
cord-283427-fef9qsik	178	15	al	al	NNP
cord-283427-fef9qsik	178	16	.	.	.
cord-283427-fef9qsik	179	1	in	in	IN
cord-283427-fef9qsik	179	2	[	[	-LRB-
cord-283427-fef9qsik	179	3	1	1	CD
cord-283427-fef9qsik	179	4	]	]	-RRB-
cord-283427-fef9qsik	179	5	)	)	-RRB-
cord-283427-fef9qsik	180	1	Establishment	establishment	NN
cord-283427-fef9qsik	180	2	of	of	IN
cord-283427-fef9qsik	180	3	minimal	minimal	JJ
cord-283427-fef9qsik	180	4	positive	positive	JJ
cord-283427-fef9qsik	180	5	-	-	HYPH
cord-283427-fef9qsik	180	6	control	control	NN
cord-283427-fef9qsik	180	7	conditions	condition	NNS
cord-283427-fef9qsik	180	8	to	to	TO
cord-283427-fef9qsik	180	9	ensure	ensure	VB
cord-283427-fef9qsik	180	10	brain	brain	NN
cord-283427-fef9qsik	180	11	safety	safety	NN
cord-283427-fef9qsik	180	12	during	during	IN
cord-283427-fef9qsik	180	13	rapid	rapid	JJ
cord-283427-fef9qsik	180	14	development	development	NN
cord-283427-fef9qsik	180	15	of	of	IN
cord-283427-fef9qsik	180	16	emergency	emergency	NN
cord-283427-fef9qsik	180	17	vaccines	vaccine	NNS
cord-283427-fef9qsik	180	18	The	the	DT
cord-283427-fef9qsik	180	19	blood	blood	NN
cord-283427-fef9qsik	180	20	-	-	HYPH
cord-283427-fef9qsik	180	21	brain	brain	NN
cord-283427-fef9qsik	180	22	barrier	barrier	NN
cord-283427-fef9qsik	180	23	:	:	:
cord-283427-fef9qsik	180	24	an	an	DT
cord-283427-fef9qsik	180	25	overview	overview	NN
cord-283427-fef9qsik	180	26	:	:	:
cord-283427-fef9qsik	180	27	structure	structure	NN
cord-283427-fef9qsik	180	28	,	,	,
cord-283427-fef9qsik	180	29	regulation	regulation	NN
cord-283427-fef9qsik	180	30	,	,	,
cord-283427-fef9qsik	180	31	and	and	CC
cord-283427-fef9qsik	180	32	clinical	clinical	JJ
cord-283427-fef9qsik	180	33	implications	implication	NNS
cord-283427-fef9qsik	181	1	Lipopolysaccharideinduced	Lipopolysaccharideinduced	NNP
cord-283427-fef9qsik	181	2	blood	blood	NN
cord-283427-fef9qsik	181	3	-	-	HYPH
cord-283427-fef9qsik	181	4	brain	brain	NN
cord-283427-fef9qsik	181	5	barrier	barrier	NN
cord-283427-fef9qsik	181	6	disruption	disruption	NN
cord-283427-fef9qsik	181	7	:	:	:
cord-283427-fef9qsik	181	8	roles	role	NNS
cord-283427-fef9qsik	181	9	of	of	IN
cord-283427-fef9qsik	181	10	cyclooxygenase	cyclooxygenase	NN
cord-283427-fef9qsik	181	11	,	,	,
cord-283427-fef9qsik	181	12	oxidative	oxidative	JJ
cord-283427-fef9qsik	181	13	stress	stress	NN
cord-283427-fef9qsik	181	14	,	,	,
cord-283427-fef9qsik	181	15	neuroinflammation	neuroinflammation	NN
cord-283427-fef9qsik	181	16	,	,	,
cord-283427-fef9qsik	181	17	and	and	CC
cord-283427-fef9qsik	181	18	elements	element	NNS
cord-283427-fef9qsik	181	19	of	of	IN
cord-283427-fef9qsik	181	20	the	the	DT
cord-283427-fef9qsik	181	21	neurovascular	neurovascular	JJ
cord-283427-fef9qsik	181	22	unit	unit	NN
cord-283427-fef9qsik	181	23	Infectious	infectious	JJ
cord-283427-fef9qsik	181	24	diseases	disease	NNS
cord-283427-fef9qsik	181	25	epidemiology	epidemiology	NN
cord-283427-fef9qsik	181	26	Tight	tight	JJ
cord-283427-fef9qsik	181	27	junction	junction	NN
cord-283427-fef9qsik	181	28	and	and	CC
cord-283427-fef9qsik	181	29	polarity	polarity	NN
cord-283427-fef9qsik	181	30	interaction	interaction	NN
cord-283427-fef9qsik	181	31	in	in	IN
cord-283427-fef9qsik	181	32	the	the	DT
cord-283427-fef9qsik	181	33	transporting	transport	VBG
cord-283427-fef9qsik	181	34	epithelial	epithelial	JJ
cord-283427-fef9qsik	181	35	phenotype	phenotype	NN
cord-283427-fef9qsik	181	36	Occludin	Occludin	NNP
cord-283427-fef9qsik	181	37	:	:	:
cord-283427-fef9qsik	181	38	one	one	CD
cord-283427-fef9qsik	181	39	protein	protein	NN
cord-283427-fef9qsik	181	40	,	,	.
cord-283427-fef9qsik	182	1	many	many	JJ
cord-283427-fef9qsik	182	2	forms	form	NNS
cord-283427-fef9qsik	182	3	The	the	DT
cord-283427-fef9qsik	182	4	tight	tight	JJ
cord-283427-fef9qsik	182	5	junction	junction	NN
cord-283427-fef9qsik	182	6	in	in	IN
cord-283427-fef9qsik	182	7	inflammatory	inflammatory	JJ
cord-283427-fef9qsik	182	8	disease	disease	NN
cord-283427-fef9qsik	183	1	:	:	:
cord-283427-fef9qsik	183	2	communication	communication	NN
cord-283427-fef9qsik	183	3	breakdown	breakdown	NN
cord-283427-fef9qsik	184	1	The	the	DT
cord-283427-fef9qsik	184	2	knockout	knockout	NN
cord-283427-fef9qsik	184	3	of	of	IN
cord-283427-fef9qsik	184	4	miR-143	miR-143	NNP
cord-283427-fef9qsik	184	5	and	and	CC
cord-283427-fef9qsik	184	6	-145	-145	NNP
cord-283427-fef9qsik	184	7	alters	alter	VBZ
cord-283427-fef9qsik	184	8	smooth	smooth	JJ
cord-283427-fef9qsik	184	9	muscle	muscle	NN
cord-283427-fef9qsik	184	10	cell	cell	NN
cord-283427-fef9qsik	184	11	maintenance	maintenance	NN
cord-283427-fef9qsik	184	12	and	and	CC
cord-283427-fef9qsik	184	13	vascular	vascular	JJ
cord-283427-fef9qsik	184	14	homeostasis	homeostasis	NN
cord-283427-fef9qsik	184	15	in	in	IN
cord-283427-fef9qsik	184	16	mice	mouse	NNS
cord-283427-fef9qsik	184	17	:	:	:
cord-283427-fef9qsik	184	18	correlates	correlate	VBZ
cord-283427-fef9qsik	184	19	with	with	IN
cord-283427-fef9qsik	184	20	human	human	JJ
cord-283427-fef9qsik	184	21	disease	disease	NN
cord-283427-fef9qsik	185	1	The	the	DT
cord-283427-fef9qsik	185	2	tight	tight	JJ
cord-283427-fef9qsik	185	3	junction	junction	NN
cord-283427-fef9qsik	185	4	protein	protein	NN
cord-283427-fef9qsik	185	5	ZO-1	ZO-1	NNP
cord-283427-fef9qsik	185	6	establishes	establish	VBZ
cord-283427-fef9qsik	185	7	a	a	DT
cord-283427-fef9qsik	185	8	link	link	NN
cord-283427-fef9qsik	185	9	between	between	IN
cord-283427-fef9qsik	185	10	the	the	DT
cord-283427-fef9qsik	185	11	transmembrane	transmembrane	NNP
cord-283427-fef9qsik	185	12	protein	protein	NN
cord-283427-fef9qsik	185	13	occludin	occludin	NNP
cord-283427-fef9qsik	185	14	and	and	CC
cord-283427-fef9qsik	185	15	the	the	DT
cord-283427-fef9qsik	185	16	actin	actin	NN
cord-283427-fef9qsik	185	17	cytoskeleton	cytoskeleton	VB
cord-283427-fef9qsik	185	18	Experimental	experimental	JJ
cord-283427-fef9qsik	185	19	methods	method	NNS
cord-283427-fef9qsik	185	20	and	and	CC
cord-283427-fef9qsik	185	21	transport	transport	NN
cord-283427-fef9qsik	185	22	models	model	NNS
cord-283427-fef9qsik	185	23	for	for	IN
cord-283427-fef9qsik	185	24	drug	drug	NN
cord-283427-fef9qsik	185	25	delivery	delivery	NN
cord-283427-fef9qsik	185	26	across	across	IN
cord-283427-fef9qsik	185	27	the	the	DT
cord-283427-fef9qsik	185	28	blood	blood	NN
cord-283427-fef9qsik	185	29	-	-	HYPH
cord-283427-fef9qsik	185	30	brain	brain	NN
cord-283427-fef9qsik	185	31	barrier	barrier	NN
cord-283427-fef9qsik	185	32	Claudins	Claudins	NNP
cord-283427-fef9qsik	185	33	and	and	CC
cord-283427-fef9qsik	185	34	the	the	DT
cord-283427-fef9qsik	185	35	modulation	modulation	NN
cord-283427-fef9qsik	185	36	of	of	IN
cord-283427-fef9qsik	185	37	tight	tight	JJ
cord-283427-fef9qsik	185	38	junction	junction	NN
cord-283427-fef9qsik	185	39	permeability	permeability	NN
cord-283427-fef9qsik	185	40	Molecular	molecular	JJ
cord-283427-fef9qsik	185	41	physiology	physiology	NN
cord-283427-fef9qsik	185	42	and	and	CC
cord-283427-fef9qsik	185	43	pathophysiology	pathophysiology	NN
cord-283427-fef9qsik	185	44	of	of	IN
cord-283427-fef9qsik	185	45	tight	tight	JJ
cord-283427-fef9qsik	185	46	junctions	junction	NNS
cord-283427-fef9qsik	185	47	in	in	IN
cord-283427-fef9qsik	185	48	the	the	DT
cord-283427-fef9qsik	185	49	blood	blood	NN
cord-283427-fef9qsik	185	50	-	-	HYPH
cord-283427-fef9qsik	185	51	brain	brain	NN
cord-283427-fef9qsik	185	52	barrier	barrier	NN
cord-283427-fef9qsik	185	53	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-283427-fef9qsik	185	54	-	-	HYPH
cord-283427-fef9qsik	185	55	induced	induce	VBN
cord-283427-fef9qsik	185	56	blood	blood	NN
cord-283427-fef9qsik	185	57	brain	brain	NN
cord-283427-fef9qsik	185	58	barrier	barrier	NN
cord-283427-fef9qsik	185	59	permeability	permeability	NN
cord-283427-fef9qsik	185	60	is	be	VBZ
cord-283427-fef9qsik	185	61	enhanced	enhance	VBN
cord-283427-fef9qsik	185	62	by	by	IN
cord-283427-fef9qsik	185	63	alpha	alpha	NN
cord-283427-fef9qsik	185	64	-	-	HYPH
cord-283427-fef9qsik	185	65	synuclein	synuclein	NN
cord-283427-fef9qsik	185	66	expression	expression	NN
cord-283427-fef9qsik	185	67	Neonatal	neonatal	JJ
cord-283427-fef9qsik	185	68	influenza	influenza	NN
cord-283427-fef9qsik	185	69	virus	virus	NN
cord-283427-fef9qsik	185	70	infection	infection	NN
cord-283427-fef9qsik	185	71	affects	affect	VBZ
cord-283427-fef9qsik	185	72	myelination	myelination	NN
cord-283427-fef9qsik	185	73	in	in	IN
cord-283427-fef9qsik	185	74	influenza	influenza	NN
cord-283427-fef9qsik	185	75	-	-	HYPH
cord-283427-fef9qsik	185	76	recovered	recover	VBN
cord-283427-fef9qsik	185	77	mouse	mouse	NN
cord-283427-fef9qsik	185	78	brain	brain	NN
cord-283427-fef9qsik	185	79	Influenza	Influenza	NNP
cord-283427-fef9qsik	185	80	and	and	CC
cord-283427-fef9qsik	185	81	the	the	DT
cord-283427-fef9qsik	185	82	work	work	NN
cord-283427-fef9qsik	185	83	of	of	IN
cord-283427-fef9qsik	185	84	the	the	DT
cord-283427-fef9qsik	185	85	World	World	NNP
cord-283427-fef9qsik	185	86	Health	Health	NNP
cord-283427-fef9qsik	185	87	Organization	Organization	NNP
cord-283427-fef9qsik	185	88	Transient	Transient	NNP
cord-283427-fef9qsik	185	89	forebrain	forebrain	NN
cord-283427-fef9qsik	185	90	ischemia	ischemia	NN
cord-283427-fef9qsik	186	1	induces	induce	VBZ
cord-283427-fef9qsik	186	2	impairment	impairment	NN
cord-283427-fef9qsik	186	3	in	in	IN
cord-283427-fef9qsik	186	4	cognitive	cognitive	JJ
cord-283427-fef9qsik	186	5	performance	performance	NN
cord-283427-fef9qsik	186	6	prior	prior	RB
cord-283427-fef9qsik	186	7	to	to	IN
cord-283427-fef9qsik	186	8	extensive	extensive	JJ
cord-283427-fef9qsik	186	9	neuronal	neuronal	JJ
cord-283427-fef9qsik	186	10	cell	cell	NN
cord-283427-fef9qsik	186	11	death	death	NN
cord-283427-fef9qsik	186	12	in	in	IN
cord-283427-fef9qsik	186	13	Mongolian	mongolian	JJ
cord-283427-fef9qsik	186	14	gerbil	gerbil	NN
cord-283427-fef9qsik	186	15	(	(	-LRB-
cord-283427-fef9qsik	186	16	Meriones	Meriones	NNP
cord-283427-fef9qsik	186	17	unguiculatus	unguiculatus	NN
cord-283427-fef9qsik	186	18	)	)	-RRB-
cord-283427-fef9qsik	187	1	LPS	LPS	NNP
cord-283427-fef9qsik	187	2	Induces	induce	VBZ
cord-283427-fef9qsik	187	3	Occludin	Occludin	NNP
cord-283427-fef9qsik	187	4	Dysregulation	Dysregulation	NNP
cord-283427-fef9qsik	187	5	in	in	IN
cord-283427-fef9qsik	187	6	Cerebral	Cerebral	NNP
cord-283427-fef9qsik	187	7	Microvascular	Microvascular	NNP
cord-283427-fef9qsik	187	8	Endothelial	Endothelial	NNP
cord-283427-fef9qsik	187	9	Cells	Cells	NNPS
cord-283427-fef9qsik	187	10	via	via	IN
cord-283427-fef9qsik	187	11	MAPK	MAPK	NNP
cord-283427-fef9qsik	187	12	Signaling	signal	VBG
cord-283427-fef9qsik	187	13	and	and	CC
cord-283427-fef9qsik	188	1	Augmenting	augment	VBG
cord-283427-fef9qsik	188	2	MMP-2	MMP-2	NNP
cord-283427-fef9qsik	188	3	Levels	Levels	NNPS
cord-283427-fef9qsik	188	4	Brain	Brain	NNP
cord-283427-fef9qsik	188	5	endothelial	endothelial	JJ
cord-283427-fef9qsik	188	6	cell	cell	NN
cord-283427-fef9qsik	188	7	-	-	HYPH
cord-283427-fef9qsik	188	8	cell	cell	NN
cord-283427-fef9qsik	188	9	junctions	junction	NNS
cord-283427-fef9qsik	188	10	:	:	:
cord-283427-fef9qsik	188	11	how	how	WRB
cord-283427-fef9qsik	188	12	to	to	TO
cord-283427-fef9qsik	188	13	"	"	``
cord-283427-fef9qsik	188	14	open	open	VB
cord-283427-fef9qsik	188	15	"	"	''
cord-283427-fef9qsik	188	16	the	the	DT
cord-283427-fef9qsik	188	17	blood	blood	NN
cord-283427-fef9qsik	188	18	brain	brain	NN
cord-283427-fef9qsik	188	19	barrier	barrier	NN
cord-283427-fef9qsik	189	1	The	the	DT
cord-283427-fef9qsik	189	2	system	system	NN
cord-283427-fef9qsik	189	3	of	of	IN
cord-283427-fef9qsik	189	4	cerebrospinal	cerebrospinal	JJ
cord-283427-fef9qsik	189	5	fluid	fluid	NN
cord-283427-fef9qsik	189	6	-	-	HYPH
cord-283427-fef9qsik	189	7	contacting	contact	VBG
cord-283427-fef9qsik	189	8	neurons	neuron	NNS
cord-283427-fef9qsik	189	9	.	.	.
cord-283427-fef9qsik	190	1	Its	-PRON-	PRP$
cord-283427-fef9qsik	190	2	supposed	suppose	VBN
cord-283427-fef9qsik	190	3	role	role	NN
cord-283427-fef9qsik	190	4	in	in	IN
cord-283427-fef9qsik	190	5	the	the	DT
cord-283427-fef9qsik	190	6	nonsynaptic	nonsynaptic	JJ
cord-283427-fef9qsik	190	7	signal	signal	NN
cord-283427-fef9qsik	190	8	transmission	transmission	NN
cord-283427-fef9qsik	190	9	of	of	IN
cord-283427-fef9qsik	190	10	the	the	DT
cord-283427-fef9qsik	190	11	brain	brain	NN
cord-283427-fef9qsik	190	12	Neuronal	neuronal	JJ
cord-283427-fef9qsik	190	13	regulation	regulation	NN
cord-283427-fef9qsik	190	14	of	of	IN
cord-283427-fef9qsik	190	15	energy	energy	NN
cord-283427-fef9qsik	190	16	homeostasis	homeostasis	NN
cord-283427-fef9qsik	190	17	:	:	:
cord-283427-fef9qsik	190	18	beyond	beyond	IN
cord-283427-fef9qsik	190	19	the	the	DT
cord-283427-fef9qsik	190	20	hypothalamus	hypothalamus	NN
cord-283427-fef9qsik	190	21	and	and	CC
cord-283427-fef9qsik	190	22	feeding	feed	VBG
cord-283427-fef9qsik	190	23	Time	time	NN
cord-283427-fef9qsik	190	24	-	-	HYPH
cord-283427-fef9qsik	190	25	dependent	dependent	JJ
cord-283427-fef9qsik	190	26	changes	change	NNS
cord-283427-fef9qsik	190	27	of	of	IN
cord-283427-fef9qsik	190	28	calbindin	calbindin	NNS
cord-283427-fef9qsik	190	29	D-28	D-28	NNP
cord-283427-fef9qsik	190	30	K	K	NNP
cord-283427-fef9qsik	190	31	and	and	CC
cord-283427-fef9qsik	190	32	parvalbumin	parvalbumin	VBD
cord-283427-fef9qsik	190	33	immunoreactivity	immunoreactivity	NN
cord-283427-fef9qsik	190	34	in	in	IN
cord-283427-fef9qsik	190	35	the	the	DT
cord-283427-fef9qsik	190	36	hippocampus	hippocampus	NN
cord-283427-fef9qsik	190	37	of	of	IN
cord-283427-fef9qsik	190	38	rats	rat	NNS
cord-283427-fef9qsik	190	39	with	with	IN
cord-283427-fef9qsik	190	40	streptozotocin	streptozotocin	NNS
cord-283427-fef9qsik	190	41	-	-	HYPH
cord-283427-fef9qsik	190	42	induced	induce	VBN
cord-283427-fef9qsik	190	43	type	type	NN
cord-283427-fef9qsik	190	44	1	1	CD
cord-283427-fef9qsik	190	45	diabetes	diabetes	NN
cord-283427-fef9qsik	191	1	Enhanced	enhanced	JJ
cord-283427-fef9qsik	191	2	expressions	expression	NNS
cord-283427-fef9qsik	191	3	of	of	IN
cord-283427-fef9qsik	191	4	arginine	arginine	NN
cord-283427-fef9qsik	191	5	vasopressin	vasopressin	NN
cord-283427-fef9qsik	191	6	(	(	-LRB-
cord-283427-fef9qsik	191	7	Avp	Avp	NNP
cord-283427-fef9qsik	191	8	)	)	-RRB-
cord-283427-fef9qsik	191	9	in	in	IN
cord-283427-fef9qsik	191	10	the	the	DT
cord-283427-fef9qsik	191	11	hypothalamic	hypothalamic	JJ
cord-283427-fef9qsik	191	12	paraventricular	paraventricular	NNP
cord-283427-fef9qsik	191	13	and	and	CC
cord-283427-fef9qsik	191	14	supraoptic	supraoptic	JJ
cord-283427-fef9qsik	191	15	nuclei	nucleus	NNS
cord-283427-fef9qsik	191	16	of	of	IN
cord-283427-fef9qsik	191	17	type	type	NN
cord-283427-fef9qsik	191	18	2	2	CD
cord-283427-fef9qsik	191	19	diabetic	diabetic	JJ
cord-283427-fef9qsik	191	20	rats	rat	NNS
cord-283427-fef9qsik	192	1	All	all	DT
cord-283427-fef9qsik	192	2	authors	author	NNS
cord-283427-fef9qsik	192	3	are	be	VBP
cord-283427-fef9qsik	192	4	appreciated	appreciate	VBN
cord-283427-fef9qsik	192	5	the	the	DT
cord-283427-fef9qsik	192	6	technical	technical	JJ
cord-283427-fef9qsik	192	7	supports	support	NNS
cord-283427-fef9qsik	192	8	of	of	IN
cord-283427-fef9qsik	192	9	Mr.	Mr.	NNP
cord-283427-fef9qsik	192	10	Kyunghyun	Kyunghyun	NNP
cord-283427-fef9qsik	192	11	Lim	Lim	NNP
cord-283427-fef9qsik	192	12	and	and	CC
cord-283427-fef9qsik	192	13	Mr.	Mr.	NNP
cord-283427-fef9qsik	192	14	Ji	Ji	NNP
cord-283427-fef9qsik	192	15	-	-	HYPH
cord-283427-fef9qsik	192	16	Kwang	Kwang	NNP
cord-283427-fef9qsik	192	17	Lee	Lee	NNP
cord-283427-fef9qsik	192	18	at	at	IN
cord-283427-fef9qsik	192	19	department	department	NN
cord-283427-fef9qsik	192	20	of	of	IN
cord-283427-fef9qsik	192	21	biomedical	biomedical	NNP
cord-283427-fef9qsik	192	22	laboratory	laboratory	NN
cord-283427-fef9qsik	192	23	science	science	NN
cord-283427-fef9qsik	192	24	,	,	,
cord-283427-fef9qsik	192	25	Soonchunhyang	Soonchunhyang	NNP
cord-283427-fef9qsik	192	26	University	University	NNP
cord-283427-fef9qsik	192	27	.	.	.
cord-283427-fef9qsik	193	1	Authors	author	NNS
cord-283427-fef9qsik	193	2	'	'	POS
cord-283427-fef9qsik	193	3	contributions	contribution	NNS
cord-283427-fef9qsik	193	4	GHK	GHK	NNP
cord-283427-fef9qsik	193	5	;	;	:
cord-283427-fef9qsik	193	6	performing	perform	VBG
cord-283427-fef9qsik	193	7	experiment	experiment	NN
cord-283427-fef9qsik	193	8	,	,	,
cord-283427-fef9qsik	193	9	analysis	analysis	NN
cord-283427-fef9qsik	193	10	of	of	IN
cord-283427-fef9qsik	193	11	data	datum	NNS
cord-283427-fef9qsik	193	12	and	and	CC
cord-283427-fef9qsik	193	13	writing	writing	NN
cord-283427-fef9qsik	193	14	manuscript	manuscript	NN
cord-283427-fef9qsik	193	15	,	,	,
cord-283427-fef9qsik	193	16	SSY	SSY	NNP
cord-283427-fef9qsik	193	17	;	;	:
cord-283427-fef9qsik	193	18	designing	design	VBG
cord-283427-fef9qsik	193	19	of	of	IN
cord-283427-fef9qsik	193	20	the	the	DT
cord-283427-fef9qsik	193	21	study	study	NN
cord-283427-fef9qsik	193	22	,	,	,
cord-283427-fef9qsik	193	23	analysis	analysis	NN
cord-283427-fef9qsik	193	24	and	and	CC
cord-283427-fef9qsik	193	25	interpretation	interpretation	NN
cord-283427-fef9qsik	193	26	of	of	IN
cord-283427-fef9qsik	193	27	data	datum	NNS
cord-283427-fef9qsik	193	28	and	and	CC
cord-283427-fef9qsik	193	29	final	final	JJ
cord-283427-fef9qsik	193	30	approval	approval	NN
cord-283427-fef9qsik	193	31	of	of	IN
cord-283427-fef9qsik	193	32	the	the	DT
cord-283427-fef9qsik	193	33	version	version	NN
cord-283427-fef9qsik	193	34	to	to	TO
cord-283427-fef9qsik	193	35	be	be	VB
cord-283427-fef9qsik	193	36	submitted	submit	VBN
cord-283427-fef9qsik	193	37	.	.	.
cord-283427-fef9qsik	194	1	Both	both	DT
cord-283427-fef9qsik	194	2	authors	author	NNS
cord-283427-fef9qsik	194	3	read	read	VBP
cord-283427-fef9qsik	194	4	and	and	CC
cord-283427-fef9qsik	194	5	approved	approve	VBD
cord-283427-fef9qsik	194	6	the	the	DT
cord-283427-fef9qsik	194	7	final	final	JJ
cord-283427-fef9qsik	194	8	manuscript	manuscript	NN
cord-283427-fef9qsik	194	9	.	.	.
cord-283427-fef9qsik	195	1	There	there	EX
cord-283427-fef9qsik	195	2	were	be	VBD
cord-283427-fef9qsik	195	3	no	no	DT
cord-283427-fef9qsik	195	4	more	more	RBR
cord-283427-fef9qsik	195	5	related	related	JJ
cord-283427-fef9qsik	195	6	information	information	NN
cord-283427-fef9qsik	195	7	about	about	IN
cord-283427-fef9qsik	195	8	the	the	DT
cord-283427-fef9qsik	195	9	authors	author	NNS
cord-283427-fef9qsik	195	10	.	.	.
cord-283427-fef9qsik	195	11	 	 	_SP
cord-283427-fef9qsik	196	1	There	there	EX
cord-283427-fef9qsik	196	2	was	be	VBD
cord-283427-fef9qsik	196	3	some	some	DT
cord-283427-fef9qsik	196	4	supporting	support	VBG
cord-283427-fef9qsik	196	5	data	datum	NNS
cord-283427-fef9qsik	196	6	available	available	JJ
cord-283427-fef9qsik	196	7	for	for	IN
cord-283427-fef9qsik	196	8	this	this	DT
cord-283427-fef9qsik	196	9	work	work	NN
cord-283427-fef9qsik	196	10	.	.	.
cord-283427-fef9qsik	197	1	The	the	DT
cord-283427-fef9qsik	197	2	datasets	dataset	NNS
cord-283427-fef9qsik	197	3	used	use	VBN
cord-283427-fef9qsik	197	4	and/or	and/or	CC
cord-283427-fef9qsik	197	5	analyzed	analyze	VBN
cord-283427-fef9qsik	197	6	in	in	IN
cord-283427-fef9qsik	197	7	this	this	DT
cord-283427-fef9qsik	197	8	study	study	NN
cord-283427-fef9qsik	197	9	are	be	VBP
cord-283427-fef9qsik	197	10	available	available	JJ
cord-283427-fef9qsik	197	11	from	from	IN
cord-283427-fef9qsik	197	12	the	the	DT
cord-283427-fef9qsik	197	13	corresponding	correspond	VBG
cord-283427-fef9qsik	197	14	author	author	NN
cord-283427-fef9qsik	197	15	on	on	IN
cord-283427-fef9qsik	197	16	reasonable	reasonable	JJ
cord-283427-fef9qsik	197	17	request	request	NN
cord-283427-fef9qsik	197	18	.	.	.
cord-283427-fef9qsik	198	1	The	the	DT
cord-283427-fef9qsik	198	2	authors	author	NNS
cord-283427-fef9qsik	198	3	declare	declare	VBP
cord-283427-fef9qsik	198	4	that	that	IN
cord-283427-fef9qsik	198	5	they	-PRON-	PRP
cord-283427-fef9qsik	198	6	have	have	VBP
cord-283427-fef9qsik	198	7	no	no	DT
cord-283427-fef9qsik	198	8	competing	compete	VBG
cord-283427-fef9qsik	198	9	interests	interest	NNS
cord-283427-fef9qsik	198	10	.	.	.
cord-283427-fef9qsik	198	11	 	 	_SP