id sid tid token lemma pos cord-009753-6rg47f0i 1 1 key key NN cord-009753-6rg47f0i 1 2 : : : cord-009753-6rg47f0i 2 1 cord-009753 cord-009753 NNP cord-009753-6rg47f0i 2 2 - - HYPH cord-009753-6rg47f0i 2 3 6rg47f0i 6rg47f0i CD cord-009753-6rg47f0i 2 4 authors author NNS cord-009753-6rg47f0i 2 5 : : : cord-009753-6rg47f0i 2 6 Legband Legband NNP cord-009753-6rg47f0i 2 7 , , , cord-009753-6rg47f0i 2 8 Nathan Nathan NNP cord-009753-6rg47f0i 2 9 ; ; : cord-009753-6rg47f0i 2 10 Buesing Buesing NNP cord-009753-6rg47f0i 2 11 , , , cord-009753-6rg47f0i 2 12 Keely Keely NNP cord-009753-6rg47f0i 2 13 ; ; : cord-009753-6rg47f0i 2 14 Borden Borden NNP cord-009753-6rg47f0i 2 15 , , , cord-009753-6rg47f0i 2 16 Mark Mark NNP cord-009753-6rg47f0i 2 17 ; ; : cord-009753-6rg47f0i 2 18 Terry Terry NNP cord-009753-6rg47f0i 2 19 , , , cord-009753-6rg47f0i 2 20 Benjamin Benjamin NNP cord-009753-6rg47f0i 2 21 title title NN cord-009753-6rg47f0i 2 22 : : : cord-009753-6rg47f0i 2 23 The the DT cord-009753-6rg47f0i 2 24 Treatment Treatment NNP cord-009753-6rg47f0i 2 25 of of IN cord-009753-6rg47f0i 2 26 Acute acute JJ cord-009753-6rg47f0i 2 27 Respiratory Respiratory NNP cord-009753-6rg47f0i 2 28 Distress Distress NNP cord-009753-6rg47f0i 2 29 Syndrome Syndrome NNP cord-009753-6rg47f0i 2 30 in in IN cord-009753-6rg47f0i 2 31 Rats rat NNS cord-009753-6rg47f0i 2 32 With with IN cord-009753-6rg47f0i 2 33 a a DT cord-009753-6rg47f0i 2 34 Peritoneal Peritoneal NNP cord-009753-6rg47f0i 2 35 Dosing Dosing NNP cord-009753-6rg47f0i 2 36 System System NNP cord-009753-6rg47f0i 2 37 date date NN cord-009753-6rg47f0i 2 38 : : : cord-009753-6rg47f0i 2 39 2015 2015 CD cord-009753-6rg47f0i 2 40 - - HYPH cord-009753-6rg47f0i 2 41 06 06 CD cord-009753-6rg47f0i 2 42 - - HYPH cord-009753-6rg47f0i 2 43 01 01 CD cord-009753-6rg47f0i 2 44 journal journal NN cord-009753-6rg47f0i 2 45 : : : cord-009753-6rg47f0i 2 46 J J NNP cord-009753-6rg47f0i 2 47 Med Med NNP cord-009753-6rg47f0i 2 48 Device Device NNP cord-009753-6rg47f0i 2 49 DOI doi NN cord-009753-6rg47f0i 2 50 : : : cord-009753-6rg47f0i 2 51 10.1115/1.4030140 10.1115/1.4030140 CD cord-009753-6rg47f0i 2 52 sha sha NNP cord-009753-6rg47f0i 2 53 : : : cord-009753-6rg47f0i 2 54 0c68c278f99baaf74df51d2e187fb8f04fdf62db 0c68c278f99baaf74df51d2e187fb8f04fdf62db CD cord-009753-6rg47f0i 2 55 doc_id doc_id CD cord-009753-6rg47f0i 2 56 : : : cord-009753-6rg47f0i 2 57 9753 9753 CD cord-009753-6rg47f0i 2 58 cord_uid cord_uid NNS cord-009753-6rg47f0i 2 59 : : : cord-009753-6rg47f0i 2 60 6rg47f0i 6rg47f0i CD cord-009753-6rg47f0i 2 61 nan nan NNP cord-009753-6rg47f0i 2 62 Current current JJ cord-009753-6rg47f0i 2 63 medical medical JJ cord-009753-6rg47f0i 2 64 treatments treatment NNS cord-009753-6rg47f0i 2 65 for for IN cord-009753-6rg47f0i 2 66 conditions condition NNS cord-009753-6rg47f0i 2 67 involving involve VBG cord-009753-6rg47f0i 2 68 an an DT cord-009753-6rg47f0i 2 69 impaired impaired JJ cord-009753-6rg47f0i 2 70 respiratory respiratory JJ cord-009753-6rg47f0i 2 71 system system NN cord-009753-6rg47f0i 2 72 provide provide VBP cord-009753-6rg47f0i 2 73 inefficient inefficient JJ cord-009753-6rg47f0i 2 74 methods method NNS cord-009753-6rg47f0i 2 75 of of IN cord-009753-6rg47f0i 2 76 delivering deliver VBG cord-009753-6rg47f0i 2 77 oxygen oxygen NN cord-009753-6rg47f0i 2 78 to to IN cord-009753-6rg47f0i 2 79 the the DT cord-009753-6rg47f0i 2 80 patient patient NN cord-009753-6rg47f0i 2 81 . . . cord-009753-6rg47f0i 3 1 Patients patient NNS cord-009753-6rg47f0i 3 2 with with IN cord-009753-6rg47f0i 3 3 these these DT cord-009753-6rg47f0i 3 4 respiratory respiratory JJ cord-009753-6rg47f0i 3 5 dysfunctions dysfunction NNS cord-009753-6rg47f0i 3 6 are be VBP cord-009753-6rg47f0i 3 7 often often RB cord-009753-6rg47f0i 3 8 unable unable JJ cord-009753-6rg47f0i 3 9 to to TO cord-009753-6rg47f0i 3 10 get get VB cord-009753-6rg47f0i 3 11 the the DT cord-009753-6rg47f0i 3 12 required require VBN cord-009753-6rg47f0i 3 13 amount amount NN cord-009753-6rg47f0i 3 14 of of IN cord-009753-6rg47f0i 3 15 oxygen oxygen NN cord-009753-6rg47f0i 3 16 to to IN cord-009753-6rg47f0i 3 17 the the DT cord-009753-6rg47f0i 3 18 brain brain NN cord-009753-6rg47f0i 3 19 and and CC cord-009753-6rg47f0i 3 20 body body NN cord-009753-6rg47f0i 3 21 . . . cord-009753-6rg47f0i 4 1 This this DT cord-009753-6rg47f0i 4 2 can can MD cord-009753-6rg47f0i 4 3 lead lead VB cord-009753-6rg47f0i 4 4 to to IN cord-009753-6rg47f0i 4 5 delayed delay VBN cord-009753-6rg47f0i 4 6 recovery recovery NN cord-009753-6rg47f0i 4 7 from from IN cord-009753-6rg47f0i 4 8 acute acute JJ cord-009753-6rg47f0i 4 9 illness illness NN cord-009753-6rg47f0i 4 10 , , , cord-009753-6rg47f0i 4 11 multisystem multisystem JJ cord-009753-6rg47f0i 4 12 organ organ NN cord-009753-6rg47f0i 4 13 failure failure NN cord-009753-6rg47f0i 4 14 , , , cord-009753-6rg47f0i 4 15 and and CC cord-009753-6rg47f0i 4 16 ultimately ultimately RB cord-009753-6rg47f0i 4 17 death death NN cord-009753-6rg47f0i 4 18 . . . cord-009753-6rg47f0i 5 1 The the DT cord-009753-6rg47f0i 5 2 mortality mortality NN cord-009753-6rg47f0i 5 3 rate rate NN cord-009753-6rg47f0i 5 4 for for IN cord-009753-6rg47f0i 5 5 cases case NNS cord-009753-6rg47f0i 5 6 of of IN cord-009753-6rg47f0i 5 7 respiratory respiratory JJ cord-009753-6rg47f0i 5 8 dysfunctions dysfunction NNS cord-009753-6rg47f0i 5 9 has have VBZ cord-009753-6rg47f0i 5 10 been be VBN cord-009753-6rg47f0i 5 11 recently recently RB cord-009753-6rg47f0i 5 12 reported report VBN cord-009753-6rg47f0i 5 13 in in IN cord-009753-6rg47f0i 5 14 the the DT cord-009753-6rg47f0i 5 15 range range NN cord-009753-6rg47f0i 5 16 of of IN cord-009753-6rg47f0i 5 17 31 31 CD cord-009753-6rg47f0i 5 18 - - SYM cord-009753-6rg47f0i 5 19 75 75 CD cord-009753-6rg47f0i 5 20 % % NN cord-009753-6rg47f0i 5 21 [ [ -LRB- cord-009753-6rg47f0i 5 22 1 1 CD cord-009753-6rg47f0i 5 23 ] ] -RRB- cord-009753-6rg47f0i 5 24 . . . cord-009753-6rg47f0i 6 1 This this DT cord-009753-6rg47f0i 6 2 is be VBZ cord-009753-6rg47f0i 6 3 especially especially RB cord-009753-6rg47f0i 6 4 troubling troubling JJ cord-009753-6rg47f0i 6 5 considering consider VBG cord-009753-6rg47f0i 6 6 there there EX cord-009753-6rg47f0i 6 7 are be VBP cord-009753-6rg47f0i 6 8 many many JJ cord-009753-6rg47f0i 6 9 causes cause NNS cord-009753-6rg47f0i 6 10 of of IN cord-009753-6rg47f0i 6 11 respiratory respiratory JJ cord-009753-6rg47f0i 6 12 failure failure NN cord-009753-6rg47f0i 6 13 leading lead VBG cord-009753-6rg47f0i 6 14 to to IN cord-009753-6rg47f0i 6 15 acute acute JJ cord-009753-6rg47f0i 6 16 respiratory respiratory JJ cord-009753-6rg47f0i 6 17 distress distress NN cord-009753-6rg47f0i 6 18 syndrome syndrome NN cord-009753-6rg47f0i 6 19 ( ( -LRB- cord-009753-6rg47f0i 6 20 ARDS ARDS NNP cord-009753-6rg47f0i 6 21 ) ) -RRB- cord-009753-6rg47f0i 6 22 , , , cord-009753-6rg47f0i 6 23 including include VBG cord-009753-6rg47f0i 6 24 pneumonia pneumonia NN cord-009753-6rg47f0i 6 25 , , , cord-009753-6rg47f0i 6 26 sepsis sepsis NN cord-009753-6rg47f0i 6 27 , , , cord-009753-6rg47f0i 6 28 trauma trauma NN cord-009753-6rg47f0i 6 29 , , , cord-009753-6rg47f0i 6 30 chemical chemical NN cord-009753-6rg47f0i 6 31 inhalation inhalation NN cord-009753-6rg47f0i 6 32 , , , cord-009753-6rg47f0i 6 33 and and CC cord-009753-6rg47f0i 6 34 bacterial bacterial JJ cord-009753-6rg47f0i 6 35 or or CC cord-009753-6rg47f0i 6 36 viral viral JJ cord-009753-6rg47f0i 6 37 infection infection NN cord-009753-6rg47f0i 6 38 . . . cord-009753-6rg47f0i 7 1 Methods method NNS cord-009753-6rg47f0i 7 2 of of IN cord-009753-6rg47f0i 7 3 oxygenation oxygenation NN cord-009753-6rg47f0i 7 4 and and CC cord-009753-6rg47f0i 7 5 ventilation ventilation NN cord-009753-6rg47f0i 7 6 that that WDT cord-009753-6rg47f0i 7 7 bypass bypass VBP cord-009753-6rg47f0i 7 8 the the DT cord-009753-6rg47f0i 7 9 lungs lung NNS cord-009753-6rg47f0i 7 10 have have VBP cord-009753-6rg47f0i 7 11 been be VBN cord-009753-6rg47f0i 7 12 explored explore VBN cord-009753-6rg47f0i 7 13 in in IN cord-009753-6rg47f0i 7 14 an an DT cord-009753-6rg47f0i 7 15 effort effort NN cord-009753-6rg47f0i 7 16 to to TO cord-009753-6rg47f0i 7 17 promote promote VB cord-009753-6rg47f0i 7 18 lung lung NN cord-009753-6rg47f0i 7 19 recovery recovery NN cord-009753-6rg47f0i 7 20 . . . cord-009753-6rg47f0i 8 1 So so RB cord-009753-6rg47f0i 8 2 far far RB cord-009753-6rg47f0i 8 3 , , , cord-009753-6rg47f0i 8 4 only only RB cord-009753-6rg47f0i 8 5 extracorporeal extracorporeal JJ cord-009753-6rg47f0i 8 6 membrane membrane NN cord-009753-6rg47f0i 8 7 oxygenation oxygenation NN cord-009753-6rg47f0i 8 8 ( ( -LRB- cord-009753-6rg47f0i 8 9 ECMO ECMO NNP cord-009753-6rg47f0i 8 10 ) ) -RRB- cord-009753-6rg47f0i 8 11 has have VBZ cord-009753-6rg47f0i 8 12 been be VBN cord-009753-6rg47f0i 8 13 approved approve VBN cord-009753-6rg47f0i 8 14 for for IN cord-009753-6rg47f0i 8 15 medical medical JJ cord-009753-6rg47f0i 8 16 use use NN cord-009753-6rg47f0i 8 17 . . . cord-009753-6rg47f0i 9 1 However however RB cord-009753-6rg47f0i 9 2 , , , cord-009753-6rg47f0i 9 3 ECMO ECMO NNP cord-009753-6rg47f0i 9 4 is be VBZ cord-009753-6rg47f0i 9 5 an an DT cord-009753-6rg47f0i 9 6 unsatisfactory unsatisfactory JJ cord-009753-6rg47f0i 9 7 treatment treatment NN cord-009753-6rg47f0i 9 8 as as IN cord-009753-6rg47f0i 9 9 it -PRON- PRP cord-009753-6rg47f0i 9 10 possesses possess VBZ cord-009753-6rg47f0i 9 11 many many JJ cord-009753-6rg47f0i 9 12 of of IN cord-009753-6rg47f0i 9 13 its -PRON- PRP$ cord-009753-6rg47f0i 9 14 own own JJ cord-009753-6rg47f0i 9 15 risks risk NNS cord-009753-6rg47f0i 9 16 , , , cord-009753-6rg47f0i 9 17 including include VBG cord-009753-6rg47f0i 9 18 hemorrhage hemorrhage NN cord-009753-6rg47f0i 9 19 , , , cord-009753-6rg47f0i 9 20 thrombosis thrombosis NN cord-009753-6rg47f0i 9 21 , , , cord-009753-6rg47f0i 9 22 and and CC cord-009753-6rg47f0i 9 23 cannula cannula NN cord-009753-6rg47f0i 9 24 malfunction malfunction NN cord-009753-6rg47f0i 9 25 . . . cord-009753-6rg47f0i 10 1 These these DT cord-009753-6rg47f0i 10 2 risks risk NNS cord-009753-6rg47f0i 10 3 eliminate eliminate VBP cord-009753-6rg47f0i 10 4 ECMO ECMO NNP cord-009753-6rg47f0i 10 5 as as IN cord-009753-6rg47f0i 10 6 a a DT cord-009753-6rg47f0i 10 7 viable viable JJ cord-009753-6rg47f0i 10 8 treatment treatment NN cord-009753-6rg47f0i 10 9 alternative alternative NN cord-009753-6rg47f0i 10 10 for for IN cord-009753-6rg47f0i 10 11 many many JJ cord-009753-6rg47f0i 10 12 patients patient NNS cord-009753-6rg47f0i 10 13 . . . cord-009753-6rg47f0i 11 1 Therefore therefore RB cord-009753-6rg47f0i 11 2 , , , cord-009753-6rg47f0i 11 3 we -PRON- PRP cord-009753-6rg47f0i 11 4 have have VBP cord-009753-6rg47f0i 11 5 researched research VBN cord-009753-6rg47f0i 11 6 an an DT cord-009753-6rg47f0i 11 7 alternative alternative JJ cord-009753-6rg47f0i 11 8 technology technology NN cord-009753-6rg47f0i 11 9 for for IN cord-009753-6rg47f0i 11 10 delivering deliver VBG cord-009753-6rg47f0i 11 11 oxygen oxygen NN cord-009753-6rg47f0i 11 12 to to IN cord-009753-6rg47f0i 11 13 the the DT cord-009753-6rg47f0i 11 14 body body NN cord-009753-6rg47f0i 11 15 through through IN cord-009753-6rg47f0i 11 16 the the DT cord-009753-6rg47f0i 11 17 peritoneal peritoneal JJ cord-009753-6rg47f0i 11 18 cavity cavity NN cord-009753-6rg47f0i 11 19 . . . cord-009753-6rg47f0i 12 1 We -PRON- PRP cord-009753-6rg47f0i 12 2 have have VBP cord-009753-6rg47f0i 12 3 developed develop VBN cord-009753-6rg47f0i 12 4 a a DT cord-009753-6rg47f0i 12 5 peritoneal peritoneal JJ cord-009753-6rg47f0i 12 6 dosing dosing NN cord-009753-6rg47f0i 12 7 system system NN cord-009753-6rg47f0i 12 8 ( ( -LRB- cord-009753-6rg47f0i 12 9 PDS PDS NNP cord-009753-6rg47f0i 12 10 ) ) -RRB- cord-009753-6rg47f0i 12 11 which which WDT cord-009753-6rg47f0i 12 12 delivers deliver VBZ cord-009753-6rg47f0i 12 13 an an DT cord-009753-6rg47f0i 12 14 infusate infusate JJ cord-009753-6rg47f0i 12 15 solution solution NN cord-009753-6rg47f0i 12 16 to to IN cord-009753-6rg47f0i 12 17 the the DT cord-009753-6rg47f0i 12 18 peritoneal peritoneal JJ cord-009753-6rg47f0i 12 19 cavity cavity NN cord-009753-6rg47f0i 12 20 . . . cord-009753-6rg47f0i 13 1 In in IN cord-009753-6rg47f0i 13 2 order order NN cord-009753-6rg47f0i 13 3 to to TO cord-009753-6rg47f0i 13 4 provide provide VB cord-009753-6rg47f0i 13 5 a a DT cord-009753-6rg47f0i 13 6 patient patient NN cord-009753-6rg47f0i 13 7 with with IN cord-009753-6rg47f0i 13 8 supplemental supplemental JJ cord-009753-6rg47f0i 13 9 oxygenation oxygenation NN cord-009753-6rg47f0i 13 10 , , , cord-009753-6rg47f0i 13 11 phospholipid phospholipid NN cord-009753-6rg47f0i 13 12 shelled shell VBD cord-009753-6rg47f0i 13 13 oxygen oxygen NN cord-009753-6rg47f0i 13 14 microbubbles microbubble NNS cord-009753-6rg47f0i 13 15 ( ( -LRB- cord-009753-6rg47f0i 13 16 OMBs OMBs NNP cord-009753-6rg47f0i 13 17 ) ) -RRB- cord-009753-6rg47f0i 13 18 would would MD cord-009753-6rg47f0i 13 19 be be VB cord-009753-6rg47f0i 13 20 administered administer VBN cord-009753-6rg47f0i 13 21 to to IN cord-009753-6rg47f0i 13 22 the the DT cord-009753-6rg47f0i 13 23 patient patient NN cord-009753-6rg47f0i 13 24 . . . cord-009753-6rg47f0i 14 1 Previously previously RB cord-009753-6rg47f0i 14 2 , , , cord-009753-6rg47f0i 14 3 we -PRON- PRP cord-009753-6rg47f0i 14 4 have have VBP cord-009753-6rg47f0i 14 5 shown show VBN cord-009753-6rg47f0i 14 6 that that IN cord-009753-6rg47f0i 14 7 peritoneal peritoneal JJ cord-009753-6rg47f0i 14 8 membrane membrane NN cord-009753-6rg47f0i 14 9 oxygenation oxygenation NN cord-009753-6rg47f0i 14 10 ( ( -LRB- cord-009753-6rg47f0i 14 11 PMO PMO NNP cord-009753-6rg47f0i 14 12 ) ) -RRB- cord-009753-6rg47f0i 14 13 with with IN cord-009753-6rg47f0i 14 14 OMBs OMBs NNP cord-009753-6rg47f0i 14 15 is be VBZ cord-009753-6rg47f0i 14 16 a a DT cord-009753-6rg47f0i 14 17 possible possible JJ cord-009753-6rg47f0i 14 18 treatment treatment NN cord-009753-6rg47f0i 14 19 method method NN cord-009753-6rg47f0i 14 20 in in IN cord-009753-6rg47f0i 14 21 acute acute JJ cord-009753-6rg47f0i 14 22 lung lung NN cord-009753-6rg47f0i 14 23 injury injury NN cord-009753-6rg47f0i 14 24 models model NNS cord-009753-6rg47f0i 14 25 [ [ -LRB- cord-009753-6rg47f0i 14 26 2 2 CD cord-009753-6rg47f0i 14 27 ] ] -RRB- cord-009753-6rg47f0i 14 28 . . . cord-009753-6rg47f0i 15 1 We -PRON- PRP cord-009753-6rg47f0i 15 2 are be VBP cord-009753-6rg47f0i 15 3 now now RB cord-009753-6rg47f0i 15 4 extending extend VBG cord-009753-6rg47f0i 15 5 the the DT cord-009753-6rg47f0i 15 6 validity validity NN cord-009753-6rg47f0i 15 7 of of IN cord-009753-6rg47f0i 15 8 PMO PMO NNP cord-009753-6rg47f0i 15 9 treatment treatment NN cord-009753-6rg47f0i 15 10 by by IN cord-009753-6rg47f0i 15 11 testing test VBG cord-009753-6rg47f0i 15 12 in in IN cord-009753-6rg47f0i 15 13 long long JJ cord-009753-6rg47f0i 15 14 term term NN cord-009753-6rg47f0i 15 15 disease disease NN cord-009753-6rg47f0i 15 16 models model NNS cord-009753-6rg47f0i 15 17 , , , cord-009753-6rg47f0i 15 18 which which WDT cord-009753-6rg47f0i 15 19 more more RBR cord-009753-6rg47f0i 15 20 accurately accurately RB cord-009753-6rg47f0i 15 21 reflect reflect VBP cord-009753-6rg47f0i 15 22 clinical clinical JJ cord-009753-6rg47f0i 15 23 scenarios scenario NNS cord-009753-6rg47f0i 15 24 . . . cord-009753-6rg47f0i 16 1 ARDS ARDS NNP cord-009753-6rg47f0i 16 2 is be VBZ cord-009753-6rg47f0i 16 3 a a DT cord-009753-6rg47f0i 16 4 medical medical JJ cord-009753-6rg47f0i 16 5 condition condition NN cord-009753-6rg47f0i 16 6 that that WDT cord-009753-6rg47f0i 16 7 has have VBZ cord-009753-6rg47f0i 16 8 been be VBN cord-009753-6rg47f0i 16 9 well well RB cord-009753-6rg47f0i 16 10 established establish VBN cord-009753-6rg47f0i 16 11 in in IN cord-009753-6rg47f0i 16 12 animal animal NN cord-009753-6rg47f0i 16 13 models model NNS cord-009753-6rg47f0i 16 14 . . . cord-009753-6rg47f0i 17 1 Rat rat NN cord-009753-6rg47f0i 17 2 models model NNS cord-009753-6rg47f0i 17 3 of of IN cord-009753-6rg47f0i 17 4 ARDS ARDS NNP cord-009753-6rg47f0i 17 5 have have VBP cord-009753-6rg47f0i 17 6 been be VBN cord-009753-6rg47f0i 17 7 well well RB cord-009753-6rg47f0i 17 8 established establish VBN cord-009753-6rg47f0i 17 9 by by IN cord-009753-6rg47f0i 17 10 tracheal tracheal JJ cord-009753-6rg47f0i 17 11 delivery delivery NN cord-009753-6rg47f0i 17 12 of of IN cord-009753-6rg47f0i 17 13 the the DT cord-009753-6rg47f0i 17 14 endotoxin endotoxin NN cord-009753-6rg47f0i 17 15 , , , cord-009753-6rg47f0i 17 16 lipopolysaccharide lipopolysaccharide NN cord-009753-6rg47f0i 17 17 ( ( -LRB- cord-009753-6rg47f0i 17 18 LPS LPS NNP cord-009753-6rg47f0i 17 19 ) ) -RRB- cord-009753-6rg47f0i 17 20 [ [ -LRB- cord-009753-6rg47f0i 17 21 3 3 CD cord-009753-6rg47f0i 17 22 ] ] -RRB- cord-009753-6rg47f0i 17 23 . . . cord-009753-6rg47f0i 18 1 Our -PRON- PRP$ cord-009753-6rg47f0i 18 2 study study NN cord-009753-6rg47f0i 18 3 involves involve VBZ cord-009753-6rg47f0i 18 4 two two CD cord-009753-6rg47f0i 18 5 phases phase NNS cord-009753-6rg47f0i 18 6 : : : cord-009753-6rg47f0i 18 7 ( ( -LRB- cord-009753-6rg47f0i 18 8 1 1 LS cord-009753-6rg47f0i 18 9 ) ) -RRB- cord-009753-6rg47f0i 18 10 development development NN cord-009753-6rg47f0i 18 11 and and CC cord-009753-6rg47f0i 18 12 characterization characterization NN cord-009753-6rg47f0i 18 13 of of IN cord-009753-6rg47f0i 18 14 the the DT cord-009753-6rg47f0i 18 15 ARDS ARDS NNP cord-009753-6rg47f0i 18 16 disease disease NN cord-009753-6rg47f0i 18 17 model model NN cord-009753-6rg47f0i 18 18 in in IN cord-009753-6rg47f0i 18 19 rats rat NNS cord-009753-6rg47f0i 18 20 ; ; , cord-009753-6rg47f0i 18 21 ( ( -LRB- cord-009753-6rg47f0i 18 22 2 2 LS cord-009753-6rg47f0i 18 23 ) ) -RRB- cord-009753-6rg47f0i 18 24 design design NN cord-009753-6rg47f0i 18 25 and and CC cord-009753-6rg47f0i 18 26 validation validation NN cord-009753-6rg47f0i 18 27 of of IN cord-009753-6rg47f0i 18 28 ambulatory ambulatory JJ cord-009753-6rg47f0i 18 29 infusion infusion NN cord-009753-6rg47f0i 18 30 device device NN cord-009753-6rg47f0i 18 31 . . . cord-009753-6rg47f0i 19 1 In in IN cord-009753-6rg47f0i 19 2 all all DT cord-009753-6rg47f0i 19 3 phases phase NNS cord-009753-6rg47f0i 19 4 , , , cord-009753-6rg47f0i 19 5 male male JJ cord-009753-6rg47f0i 19 6 Wistar Wistar NNP cord-009753-6rg47f0i 19 7 rats rat NNS cord-009753-6rg47f0i 19 8 are be VBP cord-009753-6rg47f0i 19 9 housed house VBN cord-009753-6rg47f0i 19 10 and and CC cord-009753-6rg47f0i 19 11 cared care VBN cord-009753-6rg47f0i 19 12 for for IN cord-009753-6rg47f0i 19 13 according accord VBG cord-009753-6rg47f0i 19 14 to to IN cord-009753-6rg47f0i 19 15 the the DT cord-009753-6rg47f0i 19 16 University University NNP cord-009753-6rg47f0i 19 17 of of IN cord-009753-6rg47f0i 19 18 Nebraska Nebraska NNP cord-009753-6rg47f0i 19 19 IACUC IACUC NNP cord-009753-6rg47f0i 19 20 guidelines guideline NNS cord-009753-6rg47f0i 19 21 . . . cord-009753-6rg47f0i 20 1 Animals animal NNS cord-009753-6rg47f0i 20 2 are be VBP cord-009753-6rg47f0i 20 3 allowed allow VBN cord-009753-6rg47f0i 20 4 to to TO cord-009753-6rg47f0i 20 5 acclimate acclimate VB cord-009753-6rg47f0i 20 6 for for IN cord-009753-6rg47f0i 20 7 4 4 CD cord-009753-6rg47f0i 20 8 days day NNS cord-009753-6rg47f0i 20 9 prior prior RB cord-009753-6rg47f0i 20 10 to to IN cord-009753-6rg47f0i 20 11 the the DT cord-009753-6rg47f0i 20 12 experiments experiment NNS cord-009753-6rg47f0i 20 13 . . . cord-009753-6rg47f0i 21 1 In in IN cord-009753-6rg47f0i 21 2 phase phase NN cord-009753-6rg47f0i 21 3 1 1 CD cord-009753-6rg47f0i 21 4 , , , cord-009753-6rg47f0i 21 5 the the DT cord-009753-6rg47f0i 21 6 model model NN cord-009753-6rg47f0i 21 7 for for IN cord-009753-6rg47f0i 21 8 ARDS ARDS NNP cord-009753-6rg47f0i 21 9 is be VBZ cord-009753-6rg47f0i 21 10 evaluated evaluate VBN cord-009753-6rg47f0i 21 11 and and CC cord-009753-6rg47f0i 21 12 characterized characterize VBN cord-009753-6rg47f0i 21 13 . . . cord-009753-6rg47f0i 22 1 Rats rat NNS cord-009753-6rg47f0i 22 2 are be VBP cord-009753-6rg47f0i 22 3 sedated sedate VBN cord-009753-6rg47f0i 22 4 with with IN cord-009753-6rg47f0i 22 5 ketamine ketamine NN cord-009753-6rg47f0i 22 6 - - HYPH cord-009753-6rg47f0i 22 7 xylazine xylazine NN cord-009753-6rg47f0i 22 8 ( ( -LRB- cord-009753-6rg47f0i 22 9 18 18 CD cord-009753-6rg47f0i 22 10 - - SYM cord-009753-6rg47f0i 22 11 2 2 CD cord-009753-6rg47f0i 22 12 mg mg NNP cord-009753-6rg47f0i 22 13 / / SYM cord-009753-6rg47f0i 22 14 kg kg NNP cord-009753-6rg47f0i 22 15 ) ) -RRB- cord-009753-6rg47f0i 22 16 . . . cord-009753-6rg47f0i 23 1 Healthy healthy JJ cord-009753-6rg47f0i 23 2 baseline baseline JJ cord-009753-6rg47f0i 23 3 measurements measurement NNS cord-009753-6rg47f0i 23 4 of of IN cord-009753-6rg47f0i 23 5 weight weight NN cord-009753-6rg47f0i 23 6 , , , cord-009753-6rg47f0i 23 7 chest chest NN cord-009753-6rg47f0i 23 8 radiographs radiograph NNS cord-009753-6rg47f0i 23 9 ( ( -LRB- cord-009753-6rg47f0i 23 10 PRX PRX NNP cord-009753-6rg47f0i 23 11 90 90 CD cord-009753-6rg47f0i 23 12 , , , cord-009753-6rg47f0i 23 13 Bowie Bowie NNP cord-009753-6rg47f0i 23 14 ) ) -RRB- cord-009753-6rg47f0i 23 15 , , , cord-009753-6rg47f0i 23 16 pulse pulse NN cord-009753-6rg47f0i 23 17 oximetry oximetry NN cord-009753-6rg47f0i 23 18 ( ( -LRB- cord-009753-6rg47f0i 23 19 PhysioSuite PhysioSuite NNP cord-009753-6rg47f0i 23 20 , , , cord-009753-6rg47f0i 23 21 Kent Kent NNP cord-009753-6rg47f0i 23 22 Scientific Scientific NNP cord-009753-6rg47f0i 23 23 Corp. Corp. NNP cord-009753-6rg47f0i 23 24 ) ) -RRB- cord-009753-6rg47f0i 23 25 , , , cord-009753-6rg47f0i 23 26 and and CC cord-009753-6rg47f0i 23 27 venous venous JJ cord-009753-6rg47f0i 23 28 blood blood NN cord-009753-6rg47f0i 23 29 analysis analysis NN cord-009753-6rg47f0i 23 30 are be VBP cord-009753-6rg47f0i 23 31 then then RB cord-009753-6rg47f0i 23 32 done do VBN cord-009753-6rg47f0i 23 33 . . . cord-009753-6rg47f0i 24 1 Analysis analysis NN cord-009753-6rg47f0i 24 2 of of IN cord-009753-6rg47f0i 24 3 venous venous JJ cord-009753-6rg47f0i 24 4 blood blood NN cord-009753-6rg47f0i 24 5 from from IN cord-009753-6rg47f0i 24 6 the the DT cord-009753-6rg47f0i 24 7 tail tail NN cord-009753-6rg47f0i 24 8 vein vein NN cord-009753-6rg47f0i 24 9 was be VBD cord-009753-6rg47f0i 24 10 performed perform VBN cord-009753-6rg47f0i 24 11 with with IN cord-009753-6rg47f0i 24 12 a a DT cord-009753-6rg47f0i 24 13 handheld handheld JJ cord-009753-6rg47f0i 24 14 blood blood NN cord-009753-6rg47f0i 24 15 analyzer analyzer NN cord-009753-6rg47f0i 24 16 ( ( -LRB- cord-009753-6rg47f0i 24 17 VetScan VetScan NNP cord-009753-6rg47f0i 24 18 iSTAT istat NN cord-009753-6rg47f0i 24 19 1 1 CD cord-009753-6rg47f0i 24 20 , , , cord-009753-6rg47f0i 24 21 Abaxis Abaxis NNP cord-009753-6rg47f0i 24 22 ) ) -RRB- cord-009753-6rg47f0i 24 23 to to TO cord-009753-6rg47f0i 24 24 determine determine VB cord-009753-6rg47f0i 24 25 the the DT cord-009753-6rg47f0i 24 26 animal animal NN cord-009753-6rg47f0i 24 27 's 's POS cord-009753-6rg47f0i 24 28 blood blood NN cord-009753-6rg47f0i 24 29 gases gas NNS cord-009753-6rg47f0i 24 30 , , , cord-009753-6rg47f0i 24 31 pH ph NN cord-009753-6rg47f0i 24 32 , , , cord-009753-6rg47f0i 24 33 chemistry chemistry NN cord-009753-6rg47f0i 24 34 , , , cord-009753-6rg47f0i 24 35 and and CC cord-009753-6rg47f0i 24 36 hematocrit hematocrit NN cord-009753-6rg47f0i 24 37 . . . cord-009753-6rg47f0i 25 1 Intratracheal Intratracheal NNP cord-009753-6rg47f0i 25 2 administration administration NN cord-009753-6rg47f0i 25 3 of of IN cord-009753-6rg47f0i 25 4 0.5 0.5 CD cord-009753-6rg47f0i 25 5 ml ml NN cord-009753-6rg47f0i 25 6 saline saline NN cord-009753-6rg47f0i 25 7 with with IN cord-009753-6rg47f0i 25 8 LPS LPS NNP cord-009753-6rg47f0i 25 9 ( ( -LRB- cord-009753-6rg47f0i 25 10 7 7 CD cord-009753-6rg47f0i 25 11 mg mg NNP cord-009753-6rg47f0i 25 12 / / SYM cord-009753-6rg47f0i 25 13 kg kg NNP cord-009753-6rg47f0i 25 14 , , , cord-009753-6rg47f0i 25 15 Sigma Sigma NNP cord-009753-6rg47f0i 25 16 - - HYPH cord-009753-6rg47f0i 25 17 Aldrich Aldrich NNP cord-009753-6rg47f0i 25 18 ) ) -RRB- cord-009753-6rg47f0i 25 19 was be VBD cord-009753-6rg47f0i 25 20 performed perform VBN cord-009753-6rg47f0i 25 21 with with IN cord-009753-6rg47f0i 25 22 the the DT cord-009753-6rg47f0i 25 23 MicroSprayer MicroSprayer NNP cord-009753-6rg47f0i 25 24 V V NNP cord-009753-6rg47f0i 25 25 R R NNP cord-009753-6rg47f0i 25 26 Aerosolizer Aerosolizer NNP cord-009753-6rg47f0i 25 27 ( ( -LRB- cord-009753-6rg47f0i 25 28 Model Model NNP cord-009753-6rg47f0i 25 29 IA-1B IA-1B NNP cord-009753-6rg47f0i 25 30 - - HYPH cord-009753-6rg47f0i 25 31 R R NNP cord-009753-6rg47f0i 25 32 , , , cord-009753-6rg47f0i 25 33 PennCentury PennCentury NNP cord-009753-6rg47f0i 25 34 ) ) -RRB- cord-009753-6rg47f0i 25 35 . . . cord-009753-6rg47f0i 26 1 An an DT cord-009753-6rg47f0i 26 2 additional additional JJ cord-009753-6rg47f0i 26 3 negative negative JJ cord-009753-6rg47f0i 26 4 control control NN cord-009753-6rg47f0i 26 5 ( ( -LRB- cord-009753-6rg47f0i 26 6 NC NC NNP cord-009753-6rg47f0i 26 7 ) ) -RRB- cord-009753-6rg47f0i 26 8 group group NN cord-009753-6rg47f0i 26 9 was be VBD cord-009753-6rg47f0i 26 10 not not RB cord-009753-6rg47f0i 26 11 administered administer VBN cord-009753-6rg47f0i 26 12 with with IN cord-009753-6rg47f0i 26 13 any any DT cord-009753-6rg47f0i 26 14 intratracheal intratracheal NN cord-009753-6rg47f0i 26 15 solution solution NN cord-009753-6rg47f0i 26 16 . . . cord-009753-6rg47f0i 27 1 Observation observation NN cord-009753-6rg47f0i 27 2 and and CC cord-009753-6rg47f0i 27 3 collection collection NN cord-009753-6rg47f0i 27 4 of of IN cord-009753-6rg47f0i 27 5 daily daily JJ cord-009753-6rg47f0i 27 6 blood blood NN cord-009753-6rg47f0i 27 7 samples sample NNS cord-009753-6rg47f0i 27 8 and and CC cord-009753-6rg47f0i 27 9 chest chest NN cord-009753-6rg47f0i 27 10 radiographs radiograph NNS cord-009753-6rg47f0i 27 11 of of IN cord-009753-6rg47f0i 27 12 each each DT cord-009753-6rg47f0i 27 13 animal animal NN cord-009753-6rg47f0i 27 14 were be VBD cord-009753-6rg47f0i 27 15 performed perform VBN cord-009753-6rg47f0i 27 16 until until IN cord-009753-6rg47f0i 27 17 death death NN cord-009753-6rg47f0i 27 18 or or CC cord-009753-6rg47f0i 27 19 at at IN cord-009753-6rg47f0i 27 20 7 7 CD cord-009753-6rg47f0i 27 21 days day NNS cord-009753-6rg47f0i 27 22 post post NN cord-009753-6rg47f0i 27 23 LPS LPS NNP cord-009753-6rg47f0i 27 24 administration administration NN cord-009753-6rg47f0i 27 25 . . . cord-009753-6rg47f0i 28 1 Upon upon IN cord-009753-6rg47f0i 28 2 completion completion NN cord-009753-6rg47f0i 28 3 of of IN cord-009753-6rg47f0i 28 4 the the DT cord-009753-6rg47f0i 28 5 observation observation NN cord-009753-6rg47f0i 28 6 period period NN cord-009753-6rg47f0i 28 7 , , , cord-009753-6rg47f0i 28 8 living live VBG cord-009753-6rg47f0i 28 9 animals animal NNS cord-009753-6rg47f0i 28 10 are be VBP cord-009753-6rg47f0i 28 11 then then RB cord-009753-6rg47f0i 28 12 euthanized euthanize VBN cord-009753-6rg47f0i 28 13 with with IN cord-009753-6rg47f0i 28 14 sodium sodium NN cord-009753-6rg47f0i 28 15 pentobarbital pentobarbital NN cord-009753-6rg47f0i 28 16 . . . cord-009753-6rg47f0i 29 1 Lung lung NN cord-009753-6rg47f0i 29 2 tissue tissue NN cord-009753-6rg47f0i 29 3 was be VBD cord-009753-6rg47f0i 29 4 hematoxylin hematoxylin JJ cord-009753-6rg47f0i 29 5 and and CC cord-009753-6rg47f0i 29 6 eosin eosin NNS cord-009753-6rg47f0i 29 7 stained stain VBD cord-009753-6rg47f0i 29 8 and and CC cord-009753-6rg47f0i 29 9 sent send VBD cord-009753-6rg47f0i 29 10 to to IN cord-009753-6rg47f0i 29 11 an an DT cord-009753-6rg47f0i 29 12 independent independent JJ cord-009753-6rg47f0i 29 13 pathologist pathologist NN cord-009753-6rg47f0i 29 14 for for IN cord-009753-6rg47f0i 29 15 lung lung NN cord-009753-6rg47f0i 29 16 injury injury NN cord-009753-6rg47f0i 29 17 scoring score VBG cord-009753-6rg47f0i 29 18 [ [ -LRB- cord-009753-6rg47f0i 29 19 4 4 CD cord-009753-6rg47f0i 29 20 ] ] -RRB- cord-009753-6rg47f0i 29 21 . . . cord-009753-6rg47f0i 30 1 Phase phase NN cord-009753-6rg47f0i 30 2 2 2 CD cord-009753-6rg47f0i 30 3 is be VBZ cord-009753-6rg47f0i 30 4 the the DT cord-009753-6rg47f0i 30 5 development development NN cord-009753-6rg47f0i 30 6 of of IN cord-009753-6rg47f0i 30 7 an an DT cord-009753-6rg47f0i 30 8 ambulatory ambulatory JJ cord-009753-6rg47f0i 30 9 delivery delivery NN cord-009753-6rg47f0i 30 10 system system NN cord-009753-6rg47f0i 30 11 that that WDT cord-009753-6rg47f0i 30 12 will will MD cord-009753-6rg47f0i 30 13 infuse infuse VB cord-009753-6rg47f0i 30 14 fluid fluid NN cord-009753-6rg47f0i 30 15 to to IN cord-009753-6rg47f0i 30 16 the the DT cord-009753-6rg47f0i 30 17 rat rat NN cord-009753-6rg47f0i 30 18 's 's POS cord-009753-6rg47f0i 30 19 peritoneal peritoneal JJ cord-009753-6rg47f0i 30 20 cavity cavity NN cord-009753-6rg47f0i 30 21 for for IN cord-009753-6rg47f0i 30 22 treatment treatment NN cord-009753-6rg47f0i 30 23 . . . cord-009753-6rg47f0i 31 1 The the DT cord-009753-6rg47f0i 31 2 PDS PDS NNP cord-009753-6rg47f0i 31 3 must must MD cord-009753-6rg47f0i 31 4 fulfill fulfill VB cord-009753-6rg47f0i 31 5 several several JJ cord-009753-6rg47f0i 31 6 design design NN cord-009753-6rg47f0i 31 7 criteria criterion NNS cord-009753-6rg47f0i 31 8 : : : cord-009753-6rg47f0i 31 9 ( ( -LRB- cord-009753-6rg47f0i 31 10 1 1 LS cord-009753-6rg47f0i 31 11 ) ) -RRB- cord-009753-6rg47f0i 31 12 continuously continuously RB cord-009753-6rg47f0i 31 13 treat treat VB cord-009753-6rg47f0i 31 14 four four CD cord-009753-6rg47f0i 31 15 rats rat NNS cord-009753-6rg47f0i 31 16 simultaneously simultaneously RB cord-009753-6rg47f0i 31 17 with with IN cord-009753-6rg47f0i 31 18 the the DT cord-009753-6rg47f0i 31 19 same same JJ cord-009753-6rg47f0i 31 20 or or CC cord-009753-6rg47f0i 31 21 different different JJ cord-009753-6rg47f0i 31 22 infusates infusate NNS cord-009753-6rg47f0i 31 23 ; ; , cord-009753-6rg47f0i 31 24 ( ( -LRB- cord-009753-6rg47f0i 31 25 2 2 LS cord-009753-6rg47f0i 31 26 ) ) -RRB- cord-009753-6rg47f0i 31 27 infusate infusate NN cord-009753-6rg47f0i 31 28 needs need VBZ cord-009753-6rg47f0i 31 29 to to TO cord-009753-6rg47f0i 31 30 be be VB cord-009753-6rg47f0i 31 31 stored store VBN cord-009753-6rg47f0i 31 32 at at IN cord-009753-6rg47f0i 31 33 a a DT cord-009753-6rg47f0i 31 34 temperature temperature NN cord-009753-6rg47f0i 31 35 range range NN cord-009753-6rg47f0i 31 36 of of IN cord-009753-6rg47f0i 31 37 2 2 CD cord-009753-6rg47f0i 31 38 - - SYM cord-009753-6rg47f0i 31 39 8 8 CD cord-009753-6rg47f0i 31 40 C c NN cord-009753-6rg47f0i 31 41 ; ; , cord-009753-6rg47f0i 31 42 ( ( -LRB- cord-009753-6rg47f0i 31 43 3 3 LS cord-009753-6rg47f0i 31 44 ) ) -RRB- cord-009753-6rg47f0i 31 45 warm warm VB cord-009753-6rg47f0i 31 46 the the DT cord-009753-6rg47f0i 31 47 infusate infusate NN cord-009753-6rg47f0i 31 48 to to IN cord-009753-6rg47f0i 31 49 37 37 CD cord-009753-6rg47f0i 31 50 C c NN cord-009753-6rg47f0i 31 51 immediately immediately RB cord-009753-6rg47f0i 31 52 before before IN cord-009753-6rg47f0i 31 53 delivery delivery NN cord-009753-6rg47f0i 31 54 to to IN cord-009753-6rg47f0i 31 55 the the DT cord-009753-6rg47f0i 31 56 animal animal NN cord-009753-6rg47f0i 31 57 ; ; : cord-009753-6rg47f0i 31 58 ( ( -LRB- cord-009753-6rg47f0i 31 59 4 4 LS cord-009753-6rg47f0i 31 60 ) ) -RRB- cord-009753-6rg47f0i 31 61 gently gently RB cord-009753-6rg47f0i 31 62 agitate agitate VB cord-009753-6rg47f0i 31 63 solution solution NN cord-009753-6rg47f0i 31 64 to to TO cord-009753-6rg47f0i 31 65 prevent prevent VB cord-009753-6rg47f0i 31 66 dissociation dissociation NN cord-009753-6rg47f0i 31 67 of of IN cord-009753-6rg47f0i 31 68 microbubbles microbubble NNS cord-009753-6rg47f0i 31 69 ; ; : cord-009753-6rg47f0i 31 70 ( ( -LRB- cord-009753-6rg47f0i 31 71 5 5 LS cord-009753-6rg47f0i 31 72 ) ) -RRB- cord-009753-6rg47f0i 31 73 prevent prevent VB cord-009753-6rg47f0i 31 74 tubing tubing NN cord-009753-6rg47f0i 31 75 from from IN cord-009753-6rg47f0i 31 76 restraining restrain VBG cord-009753-6rg47f0i 31 77 the the DT cord-009753-6rg47f0i 31 78 rat rat NN cord-009753-6rg47f0i 31 79 or or CC cord-009753-6rg47f0i 31 80 being be VBG cord-009753-6rg47f0i 31 81 harmed harm VBN cord-009753-6rg47f0i 31 82 by by IN cord-009753-6rg47f0i 31 83 the the DT cord-009753-6rg47f0i 31 84 rat rat NN cord-009753-6rg47f0i 31 85 ; ; : cord-009753-6rg47f0i 31 86 ( ( -LRB- cord-009753-6rg47f0i 31 87 6 6 LS cord-009753-6rg47f0i 31 88 ) ) -RRB- cord-009753-6rg47f0i 31 89 be be VB cord-009753-6rg47f0i 31 90 compatible compatible JJ cord-009753-6rg47f0i 31 91 with with IN cord-009753-6rg47f0i 31 92 current current JJ cord-009753-6rg47f0i 31 93 facility facility NN cord-009753-6rg47f0i 31 94 housing housing NN cord-009753-6rg47f0i 31 95 and and CC cord-009753-6rg47f0i 31 96 cages cage NNS cord-009753-6rg47f0i 31 97 . . . cord-009753-6rg47f0i 32 1 The the DT cord-009753-6rg47f0i 32 2 PDS PDS NNP cord-009753-6rg47f0i 32 3 will will MD cord-009753-6rg47f0i 32 4 be be VB cord-009753-6rg47f0i 32 5 validated validate VBN cord-009753-6rg47f0i 32 6 by by IN cord-009753-6rg47f0i 32 7 constant constant JJ cord-009753-6rg47f0i 32 8 observation observation NN cord-009753-6rg47f0i 32 9 in in IN cord-009753-6rg47f0i 32 10 trials trial NNS cord-009753-6rg47f0i 32 11 with with IN cord-009753-6rg47f0i 32 12 healthy healthy JJ cord-009753-6rg47f0i 32 13 animals animal NNS cord-009753-6rg47f0i 32 14 to to TO cord-009753-6rg47f0i 32 15 ensure ensure VB cord-009753-6rg47f0i 32 16 the the DT cord-009753-6rg47f0i 32 17 system system NN cord-009753-6rg47f0i 32 18 fulfills fulfill VBZ cord-009753-6rg47f0i 32 19 the the DT cord-009753-6rg47f0i 32 20 animal animal NN cord-009753-6rg47f0i 32 21 's 's POS cord-009753-6rg47f0i 32 22 safety safety NN cord-009753-6rg47f0i 32 23 and and CC cord-009753-6rg47f0i 32 24 tubing tubing NN cord-009753-6rg47f0i 32 25 requirements requirement NNS cord-009753-6rg47f0i 32 26 . . . cord-009753-6rg47f0i 33 1 For for IN cord-009753-6rg47f0i 33 2 phase phase NN cord-009753-6rg47f0i 33 3 1 1 CD cord-009753-6rg47f0i 33 4 , , , cord-009753-6rg47f0i 33 5 trials trial NNS cord-009753-6rg47f0i 33 6 have have VBP cord-009753-6rg47f0i 33 7 been be VBN cord-009753-6rg47f0i 33 8 completed complete VBN cord-009753-6rg47f0i 33 9 for for IN cord-009753-6rg47f0i 33 10 7 7 CD cord-009753-6rg47f0i 33 11 day day NN cord-009753-6rg47f0i 33 12 LPS LPS NNP cord-009753-6rg47f0i 33 13 and and CC cord-009753-6rg47f0i 33 14 NC NC NNP cord-009753-6rg47f0i 33 15 groups group NNS cord-009753-6rg47f0i 33 16 . . . cord-009753-6rg47f0i 34 1 Eight eight CD cord-009753-6rg47f0i 34 2 rats rat NNS cord-009753-6rg47f0i 34 3 ( ( -LRB- cord-009753-6rg47f0i 34 4 m m NNP cord-009753-6rg47f0i 34 5 ¼ ¼ NNP cord-009753-6rg47f0i 34 6 541 541 CD cord-009753-6rg47f0i 34 7 6 6 CD cord-009753-6rg47f0i 34 8 60 60 CD cord-009753-6rg47f0i 34 9 g g NN cord-009753-6rg47f0i 34 10 ) ) -RRB- cord-009753-6rg47f0i 34 11 were be VBD cord-009753-6rg47f0i 34 12 successfully successfully RB cord-009753-6rg47f0i 34 13 administered administer VBN cord-009753-6rg47f0i 34 14 aerosolized aerosolized JJ cord-009753-6rg47f0i 34 15 LPS lp NNS cord-009753-6rg47f0i 34 16 and and CC cord-009753-6rg47f0i 34 17 all all DT cord-009753-6rg47f0i 34 18 developed develop VBD cord-009753-6rg47f0i 34 19 ARDS ARDS NNP cord-009753-6rg47f0i 34 20 while while IN cord-009753-6rg47f0i 34 21 two two CD cord-009753-6rg47f0i 34 22 rats rat NNS cord-009753-6rg47f0i 34 23 ( ( -LRB- cord-009753-6rg47f0i 34 24 m m NNP cord-009753-6rg47f0i 34 25 ¼ ¼ NNP cord-009753-6rg47f0i 34 26 556 556 CD cord-009753-6rg47f0i 34 27 6 6 CD cord-009753-6rg47f0i 34 28 96 96 CD cord-009753-6rg47f0i 34 29 g g NN cord-009753-6rg47f0i 34 30 ) ) -RRB- cord-009753-6rg47f0i 34 31 were be VBD cord-009753-6rg47f0i 34 32 selected select VBN cord-009753-6rg47f0i 34 33 for for IN cord-009753-6rg47f0i 34 34 the the DT cord-009753-6rg47f0i 34 35 NC NC NNP cord-009753-6rg47f0i 34 36 group group NN cord-009753-6rg47f0i 34 37 . . . cord-009753-6rg47f0i 35 1 The the DT cord-009753-6rg47f0i 35 2 overall overall JJ cord-009753-6rg47f0i 35 3 mortality mortality NN cord-009753-6rg47f0i 35 4 rate rate NN cord-009753-6rg47f0i 35 5 was be VBD cord-009753-6rg47f0i 35 6 37.5 37.5 CD cord-009753-6rg47f0i 35 7 % % NN cord-009753-6rg47f0i 35 8 for for IN cord-009753-6rg47f0i 35 9 LPS LPS NNP cord-009753-6rg47f0i 35 10 trials trial NNS cord-009753-6rg47f0i 35 11 and and CC cord-009753-6rg47f0i 35 12 0 0 CD cord-009753-6rg47f0i 35 13 % % NN cord-009753-6rg47f0i 35 14 for for IN cord-009753-6rg47f0i 35 15 NC NC NNP cord-009753-6rg47f0i 35 16 trials trial NNS cord-009753-6rg47f0i 35 17 . . . cord-009753-6rg47f0i 36 1 All all DT cord-009753-6rg47f0i 36 2 deaths death NNS cord-009753-6rg47f0i 36 3 occurred occur VBD cord-009753-6rg47f0i 36 4 within within IN cord-009753-6rg47f0i 36 5 24 24 CD cord-009753-6rg47f0i 36 6 hr hr NN cord-009753-6rg47f0i 36 7 after after IN cord-009753-6rg47f0i 36 8 administration administration NN cord-009753-6rg47f0i 36 9 of of IN cord-009753-6rg47f0i 36 10 LPS LPS NNP cord-009753-6rg47f0i 36 11 . . . cord-009753-6rg47f0i 37 1 The the DT cord-009753-6rg47f0i 37 2 remaining remain VBG cord-009753-6rg47f0i 37 3 LPS LPS NNP cord-009753-6rg47f0i 37 4 rats rat NNS cord-009753-6rg47f0i 37 5 began begin VBD cord-009753-6rg47f0i 37 6 recovering recover VBG cord-009753-6rg47f0i 37 7 over over IN cord-009753-6rg47f0i 37 8 the the DT cord-009753-6rg47f0i 37 9 course course NN cord-009753-6rg47f0i 37 10 of of IN cord-009753-6rg47f0i 37 11 the the DT cord-009753-6rg47f0i 37 12 7 7 CD cord-009753-6rg47f0i 37 13 day day NN cord-009753-6rg47f0i 37 14 observation observation NN cord-009753-6rg47f0i 37 15 period period NN cord-009753-6rg47f0i 37 16 . . . cord-009753-6rg47f0i 38 1 Chest chest NN cord-009753-6rg47f0i 38 2 radiographs radiograph NNS cord-009753-6rg47f0i 38 3 taken take VBN cord-009753-6rg47f0i 38 4 of of IN cord-009753-6rg47f0i 38 5 LPS LPS NNP cord-009753-6rg47f0i 38 6 rats rat NNS cord-009753-6rg47f0i 38 7 show show VBP cord-009753-6rg47f0i 38 8 clear clear JJ cord-009753-6rg47f0i 38 9 indications indication NNS cord-009753-6rg47f0i 38 10 of of IN cord-009753-6rg47f0i 38 11 bilateral bilateral JJ cord-009753-6rg47f0i 38 12 infiltrates infiltrate NNS cord-009753-6rg47f0i 38 13 and and CC cord-009753-6rg47f0i 38 14 interstitial interstitial JJ cord-009753-6rg47f0i 38 15 edema edema NN cord-009753-6rg47f0i 38 16 in in IN cord-009753-6rg47f0i 38 17 the the DT cord-009753-6rg47f0i 38 18 lungs lung NNS cord-009753-6rg47f0i 38 19 ( ( -LRB- cord-009753-6rg47f0i 38 20 Fig fig NN cord-009753-6rg47f0i 38 21 . . . cord-009753-6rg47f0i 38 22 1 1 CD cord-009753-6rg47f0i 38 23 ) ) -RRB- cord-009753-6rg47f0i 38 24 . . . cord-009753-6rg47f0i 39 1 The the DT cord-009753-6rg47f0i 39 2 LPS LPS NNP cord-009753-6rg47f0i 39 3 group group NN cord-009753-6rg47f0i 39 4 showed show VBD cord-009753-6rg47f0i 39 5 a a DT cord-009753-6rg47f0i 39 6 dramatic dramatic JJ cord-009753-6rg47f0i 39 7 loss loss NN cord-009753-6rg47f0i 39 8 in in IN cord-009753-6rg47f0i 39 9 lung lung NN cord-009753-6rg47f0i 39 10 function function NN cord-009753-6rg47f0i 39 11 from from IN cord-009753-6rg47f0i 39 12 the the DT cord-009753-6rg47f0i 39 13 observed observed JJ cord-009753-6rg47f0i 39 14 SpO spo JJ cord-009753-6rg47f0i 39 15 2 2 CD cord-009753-6rg47f0i 39 16 levels level NNS cord-009753-6rg47f0i 39 17 when when WRB cord-009753-6rg47f0i 39 18 compared compare VBN cord-009753-6rg47f0i 39 19 to to IN cord-009753-6rg47f0i 39 20 NCs NCs NNP cord-009753-6rg47f0i 39 21 ( ( -LRB- cord-009753-6rg47f0i 39 22 Fig Fig NNP cord-009753-6rg47f0i 39 23 . . NNP cord-009753-6rg47f0i 39 24 2 2 CD cord-009753-6rg47f0i 39 25 ) ) -RRB- cord-009753-6rg47f0i 39 26 . . . cord-009753-6rg47f0i 40 1 Table table NN cord-009753-6rg47f0i 40 2 1 1 CD cord-009753-6rg47f0i 40 3 shows show VBZ cord-009753-6rg47f0i 40 4 lung lung NN cord-009753-6rg47f0i 40 5 injury injury NN cord-009753-6rg47f0i 40 6 scores score NNS cord-009753-6rg47f0i 40 7 from from IN cord-009753-6rg47f0i 40 8 LPS LPS NNP cord-009753-6rg47f0i 40 9 deaths death NNS cord-009753-6rg47f0i 40 10 at at IN cord-009753-6rg47f0i 40 11 day day NN cord-009753-6rg47f0i 40 12 1 1 CD cord-009753-6rg47f0i 40 13 , , , cord-009753-6rg47f0i 40 14 and and CC cord-009753-6rg47f0i 40 15 NC NC NNP cord-009753-6rg47f0i 40 16 and and CC cord-009753-6rg47f0i 40 17 LPS LPS NNP cord-009753-6rg47f0i 40 18 trials trial NNS cord-009753-6rg47f0i 40 19 euthanized euthanize VBN cord-009753-6rg47f0i 40 20 on on IN cord-009753-6rg47f0i 40 21 day day NN cord-009753-6rg47f0i 40 22 7 7 CD cord-009753-6rg47f0i 40 23 . . . cord-009753-6rg47f0i 41 1 In in IN cord-009753-6rg47f0i 41 2 phase phase NN cord-009753-6rg47f0i 41 3 2 2 CD cord-009753-6rg47f0i 41 4 , , , cord-009753-6rg47f0i 41 5 final final JJ cord-009753-6rg47f0i 41 6 design design NN cord-009753-6rg47f0i 41 7 of of IN cord-009753-6rg47f0i 41 8 the the DT cord-009753-6rg47f0i 41 9 PDS PDS NNP cord-009753-6rg47f0i 41 10 has have VBZ cord-009753-6rg47f0i 41 11 been be VBN cord-009753-6rg47f0i 41 12 completed complete VBN cord-009753-6rg47f0i 41 13 ( ( -LRB- cord-009753-6rg47f0i 41 14 Fig Fig NNP cord-009753-6rg47f0i 41 15 . . . cord-009753-6rg47f0i 41 16 3 3 CD cord-009753-6rg47f0i 41 17 ) ) -RRB- cord-009753-6rg47f0i 41 18 . . . cord-009753-6rg47f0i 42 1 The the DT cord-009753-6rg47f0i 42 2 PDS PDS NNP cord-009753-6rg47f0i 42 3 is be VBZ cord-009753-6rg47f0i 42 4 comprised comprise VBN cord-009753-6rg47f0i 42 5 of of IN cord-009753-6rg47f0i 42 6 a a DT cord-009753-6rg47f0i 42 7 peristaltic peristaltic JJ cord-009753-6rg47f0i 42 8 pump pump NN cord-009753-6rg47f0i 42 9 , , , cord-009753-6rg47f0i 42 10 warm warm JJ cord-009753-6rg47f0i 42 11 water water NN cord-009753-6rg47f0i 42 12 bath bath NN cord-009753-6rg47f0i 42 13 , , , cord-009753-6rg47f0i 42 14 a a DT cord-009753-6rg47f0i 42 15 spring spring NN cord-009753-6rg47f0i 42 16 pullbox pullbox NN cord-009753-6rg47f0i 42 17 for for IN cord-009753-6rg47f0i 42 18 dynamic dynamic JJ cord-009753-6rg47f0i 42 19 tubing tubing NN cord-009753-6rg47f0i 42 20 restraint restraint NN cord-009753-6rg47f0i 42 21 , , , cord-009753-6rg47f0i 42 22 and and CC cord-009753-6rg47f0i 42 23 a a DT cord-009753-6rg47f0i 42 24 LabVIEW LabVIEW NNP cord-009753-6rg47f0i 42 25 control control NN cord-009753-6rg47f0i 42 26 system system NN cord-009753-6rg47f0i 42 27 . . . cord-009753-6rg47f0i 43 1 The the DT cord-009753-6rg47f0i 43 2 PDS PDS NNP cord-009753-6rg47f0i 43 3 is be VBZ cord-009753-6rg47f0i 43 4 compatible compatible JJ cord-009753-6rg47f0i 43 5 with with IN cord-009753-6rg47f0i 43 6 current current JJ cord-009753-6rg47f0i 43 7 housing housing NN cord-009753-6rg47f0i 43 8 arrangements arrangement NNS cord-009753-6rg47f0i 43 9 of of IN cord-009753-6rg47f0i 43 10 the the DT cord-009753-6rg47f0i 43 11 rats rat NNS cord-009753-6rg47f0i 43 12 and and CC cord-009753-6rg47f0i 43 13 will will MD cord-009753-6rg47f0i 43 14 not not RB cord-009753-6rg47f0i 43 15 restrict restrict VB cord-009753-6rg47f0i 43 16 their -PRON- PRP$ cord-009753-6rg47f0i 43 17 mobility mobility NN cord-009753-6rg47f0i 43 18 . . . cord-009753-6rg47f0i 44 1 Once once IN cord-009753-6rg47f0i 44 2 the the DT cord-009753-6rg47f0i 44 3 prototype prototype NN cord-009753-6rg47f0i 44 4 of of IN cord-009753-6rg47f0i 44 5 the the DT cord-009753-6rg47f0i 44 6 PDS PDS NNP cord-009753-6rg47f0i 44 7 has have VBZ cord-009753-6rg47f0i 44 8 been be VBN cord-009753-6rg47f0i 44 9 constructed construct VBN cord-009753-6rg47f0i 44 10 , , , cord-009753-6rg47f0i 44 11 tests test NNS cord-009753-6rg47f0i 44 12 will will MD cord-009753-6rg47f0i 44 13 be be VB cord-009753-6rg47f0i 44 14 completed complete VBN cord-009753-6rg47f0i 44 15 with with IN cord-009753-6rg47f0i 44 16 healthy healthy JJ cord-009753-6rg47f0i 44 17 rats rat NNS cord-009753-6rg47f0i 44 18 to to TO cord-009753-6rg47f0i 44 19 validate validate VB cord-009753-6rg47f0i 44 20 the the DT cord-009753-6rg47f0i 44 21 system system NN cord-009753-6rg47f0i 44 22 and and CC cord-009753-6rg47f0i 44 23 provide provide VB cord-009753-6rg47f0i 44 24 the the DT cord-009753-6rg47f0i 44 25 rat rat NN cord-009753-6rg47f0i 44 26 with with IN cord-009753-6rg47f0i 44 27 full full JJ cord-009753-6rg47f0i 44 28 mobility mobility NN cord-009753-6rg47f0i 44 29 . . . cord-009753-6rg47f0i 45 1 We -PRON- PRP cord-009753-6rg47f0i 45 2 expect expect VBP cord-009753-6rg47f0i 45 3 to to TO cord-009753-6rg47f0i 45 4 be be VB cord-009753-6rg47f0i 45 5 able able JJ cord-009753-6rg47f0i 45 6 to to TO cord-009753-6rg47f0i 45 7 continuously continuously RB cord-009753-6rg47f0i 45 8 dose dose VB cord-009753-6rg47f0i 45 9 saline saline NN cord-009753-6rg47f0i 45 10 , , , cord-009753-6rg47f0i 45 11 inert inert JJ cord-009753-6rg47f0i 45 12 gas gas NN cord-009753-6rg47f0i 45 13 microbubbles microbubble NNS cord-009753-6rg47f0i 45 14 ( ( -LRB- cord-009753-6rg47f0i 45 15 IMBs IMBs NNP cord-009753-6rg47f0i 45 16 ) ) -RRB- cord-009753-6rg47f0i 45 17 , , , cord-009753-6rg47f0i 45 18 and and CC cord-009753-6rg47f0i 45 19 OMBs omb NNS cord-009753-6rg47f0i 45 20 into into IN cord-009753-6rg47f0i 45 21 the the DT cord-009753-6rg47f0i 45 22 peritoneal peritoneal JJ cord-009753-6rg47f0i 45 23 cavity cavity NN cord-009753-6rg47f0i 45 24 of of IN cord-009753-6rg47f0i 45 25 four four CD cord-009753-6rg47f0i 45 26 animals animal NNS cord-009753-6rg47f0i 45 27 with with IN cord-009753-6rg47f0i 45 28 the the DT cord-009753-6rg47f0i 45 29 current current JJ cord-009753-6rg47f0i 45 30 PDS PDS NNP cord-009753-6rg47f0i 45 31 design design NN cord-009753-6rg47f0i 45 32 . . . cord-009753-6rg47f0i 46 1 Based base VBN cord-009753-6rg47f0i 46 2 upon upon IN cord-009753-6rg47f0i 46 3 our -PRON- PRP$ cord-009753-6rg47f0i 46 4 previous previous JJ cord-009753-6rg47f0i 46 5 animal animal NN cord-009753-6rg47f0i 46 6 experiments experiment NNS cord-009753-6rg47f0i 46 7 with with IN cord-009753-6rg47f0i 46 8 lung lung NN cord-009753-6rg47f0i 46 9 injuries injury NNS cord-009753-6rg47f0i 46 10 , , , cord-009753-6rg47f0i 46 11 we -PRON- PRP cord-009753-6rg47f0i 46 12 anticipate anticipate VBP cord-009753-6rg47f0i 46 13 improved improve VBN cord-009753-6rg47f0i 46 14 pulse pulse NN cord-009753-6rg47f0i 46 15 oximetry oximetry NN cord-009753-6rg47f0i 46 16 , , , cord-009753-6rg47f0i 46 17 blood blood NN cord-009753-6rg47f0i 46 18 gases gas NNS cord-009753-6rg47f0i 46 19 , , , cord-009753-6rg47f0i 46 20 and and CC cord-009753-6rg47f0i 46 21 survivability survivability NN cord-009753-6rg47f0i 46 22 in in IN cord-009753-6rg47f0i 46 23 rats rat NNS cord-009753-6rg47f0i 46 24 provided provide VBD cord-009753-6rg47f0i 46 25 OMBs OMBs NNP cord-009753-6rg47f0i 46 26 compared compare VBN cord-009753-6rg47f0i 46 27 to to IN cord-009753-6rg47f0i 46 28 those those DT cord-009753-6rg47f0i 46 29 administered administer VBN cord-009753-6rg47f0i 46 30 saline saline NN cord-009753-6rg47f0i 46 31 or or CC cord-009753-6rg47f0i 46 32 IMBs imbs NN cord-009753-6rg47f0i 46 33 . . . cord-009753-6rg47f0i 46 34 _SP cord-009753-6rg47f0i 47 1 We -PRON- PRP cord-009753-6rg47f0i 47 2 have have VBP cord-009753-6rg47f0i 47 3 developed develop VBN cord-009753-6rg47f0i 47 4 an an DT cord-009753-6rg47f0i 47 5 alternative alternative JJ cord-009753-6rg47f0i 47 6 extrapulmonary extrapulmonary JJ cord-009753-6rg47f0i 47 7 oxygenation oxygenation NN cord-009753-6rg47f0i 47 8 method method NN cord-009753-6rg47f0i 47 9 by by IN cord-009753-6rg47f0i 47 10 delivering deliver VBG cord-009753-6rg47f0i 47 11 OMBs omb NNS cord-009753-6rg47f0i 47 12 to to IN cord-009753-6rg47f0i 47 13 the the DT cord-009753-6rg47f0i 47 14 peritoneal peritoneal JJ cord-009753-6rg47f0i 47 15 cavity cavity NN cord-009753-6rg47f0i 47 16 . . . cord-009753-6rg47f0i 48 1 In in IN cord-009753-6rg47f0i 48 2 verifying verify VBG cord-009753-6rg47f0i 48 3 the the DT cord-009753-6rg47f0i 48 4 clinical clinical JJ cord-009753-6rg47f0i 48 5 benefits benefit NNS cord-009753-6rg47f0i 48 6 of of IN cord-009753-6rg47f0i 48 7 PMO PMO NNP cord-009753-6rg47f0i 48 8 treatment treatment NN cord-009753-6rg47f0i 48 9 we -PRON- PRP cord-009753-6rg47f0i 48 10 have have VBP cord-009753-6rg47f0i 48 11 devised devise VBN cord-009753-6rg47f0i 48 12 the the DT cord-009753-6rg47f0i 48 13 current current JJ cord-009753-6rg47f0i 48 14 study study NN cord-009753-6rg47f0i 48 15 . . . cord-009753-6rg47f0i 49 1 Trials trial NNS cord-009753-6rg47f0i 49 2 of of IN cord-009753-6rg47f0i 49 3 phase phase NN cord-009753-6rg47f0i 49 4 1 1 CD cord-009753-6rg47f0i 49 5 show show NN cord-009753-6rg47f0i 49 6 that that IN cord-009753-6rg47f0i 49 7 we -PRON- PRP cord-009753-6rg47f0i 49 8 are be VBP cord-009753-6rg47f0i 49 9 able able JJ cord-009753-6rg47f0i 49 10 to to TO cord-009753-6rg47f0i 49 11 repeatedly repeatedly RB cord-009753-6rg47f0i 49 12 induce induce VB cord-009753-6rg47f0i 49 13 ARDS ARDS NNP cord-009753-6rg47f0i 49 14 in in IN cord-009753-6rg47f0i 49 15 rats rat NNS cord-009753-6rg47f0i 49 16 with with IN cord-009753-6rg47f0i 49 17 our -PRON- PRP$ cord-009753-6rg47f0i 49 18 current current JJ cord-009753-6rg47f0i 49 19 methodology methodology NN cord-009753-6rg47f0i 49 20 . . . cord-009753-6rg47f0i 50 1 Analysis analysis NN cord-009753-6rg47f0i 50 2 of of IN cord-009753-6rg47f0i 50 3 BAL bal NN cord-009753-6rg47f0i 50 4 specimens specimen NNS cord-009753-6rg47f0i 50 5 is be VBZ cord-009753-6rg47f0i 50 6 pending pende VBG cord-009753-6rg47f0i 50 7 , , , cord-009753-6rg47f0i 50 8 as as IN cord-009753-6rg47f0i 50 9 we -PRON- PRP cord-009753-6rg47f0i 50 10 recently recently RB cord-009753-6rg47f0i 50 11 identified identify VBD cord-009753-6rg47f0i 50 12 a a DT cord-009753-6rg47f0i 50 13 lab lab NN cord-009753-6rg47f0i 50 14 able able JJ cord-009753-6rg47f0i 50 15 to to TO cord-009753-6rg47f0i 50 16 conduct conduct VB cord-009753-6rg47f0i 50 17 the the DT cord-009753-6rg47f0i 50 18 analysis analysis NN cord-009753-6rg47f0i 50 19 . . . cord-009753-6rg47f0i 51 1 The the DT cord-009753-6rg47f0i 51 2 final final JJ cord-009753-6rg47f0i 51 3 design design NN cord-009753-6rg47f0i 51 4 of of IN cord-009753-6rg47f0i 51 5 the the DT cord-009753-6rg47f0i 51 6 PDS PDS NNP cord-009753-6rg47f0i 51 7 has have VBZ cord-009753-6rg47f0i 51 8 been be VBN cord-009753-6rg47f0i 51 9 completed complete VBN cord-009753-6rg47f0i 51 10 and and CC cord-009753-6rg47f0i 51 11 build build NN cord-009753-6rg47f0i 51 12 of of IN cord-009753-6rg47f0i 51 13 the the DT cord-009753-6rg47f0i 51 14 prototype prototype NN cord-009753-6rg47f0i 51 15 has have VBZ cord-009753-6rg47f0i 51 16 begun begin VBN cord-009753-6rg47f0i 51 17 . . . cord-009753-6rg47f0i 52 1 Upon upon IN cord-009753-6rg47f0i 52 2 completion completion NN cord-009753-6rg47f0i 52 3 of of IN cord-009753-6rg47f0i 52 4 phase phase NN cord-009753-6rg47f0i 52 5 1 1 CD cord-009753-6rg47f0i 52 6 and and CC cord-009753-6rg47f0i 52 7 2 2 CD cord-009753-6rg47f0i 52 8 , , , cord-009753-6rg47f0i 52 9 PMO PMO NNP cord-009753-6rg47f0i 52 10 treatment treatment NN cord-009753-6rg47f0i 52 11 will will MD cord-009753-6rg47f0i 52 12 be be VB cord-009753-6rg47f0i 52 13 evaluated evaluate VBN cord-009753-6rg47f0i 52 14 . . . cord-009753-6rg47f0i 53 1 The the DT cord-009753-6rg47f0i 53 2 future future JJ cord-009753-6rg47f0i 53 3 direction direction NN cord-009753-6rg47f0i 53 4 of of IN cord-009753-6rg47f0i 53 5 this this DT cord-009753-6rg47f0i 53 6 work work NN cord-009753-6rg47f0i 53 7 after after IN cord-009753-6rg47f0i 53 8 validation validation NN cord-009753-6rg47f0i 53 9 will will MD cord-009753-6rg47f0i 53 10 focus focus VB cord-009753-6rg47f0i 53 11 on on IN cord-009753-6rg47f0i 53 12 reproducing reproduce VBG cord-009753-6rg47f0i 53 13 results result NNS cord-009753-6rg47f0i 53 14 in in IN cord-009753-6rg47f0i 53 15 large large JJ cord-009753-6rg47f0i 53 16 - - HYPH cord-009753-6rg47f0i 53 17 animal animal NN cord-009753-6rg47f0i 53 18 models model NNS cord-009753-6rg47f0i 53 19 of of IN cord-009753-6rg47f0i 53 20 moderate moderate JJ cord-009753-6rg47f0i 53 21 to to IN cord-009753-6rg47f0i 53 22 severe severe JJ cord-009753-6rg47f0i 53 23 ARDS ARDS NNP cord-009753-6rg47f0i 53 24 , , , cord-009753-6rg47f0i 53 25 and and CC cord-009753-6rg47f0i 53 26 commercializing commercialize VBG cord-009753-6rg47f0i 53 27 the the DT cord-009753-6rg47f0i 53 28 technology technology NN cord-009753-6rg47f0i 53 29 . . . cord-009753-6rg47f0i 54 1 We -PRON- PRP cord-009753-6rg47f0i 54 2 will will MD cord-009753-6rg47f0i 54 3 begin begin VB cord-009753-6rg47f0i 54 4 development development NN cord-009753-6rg47f0i 54 5 of of IN cord-009753-6rg47f0i 54 6 large large JJ cord-009753-6rg47f0i 54 7 scale scale NN cord-009753-6rg47f0i 54 8 manufacture manufacture NN cord-009753-6rg47f0i 54 9 of of IN cord-009753-6rg47f0i 54 10 OMBs omb NNS cord-009753-6rg47f0i 54 11 . . . cord-009753-6rg47f0i 55 1 We -PRON- PRP cord-009753-6rg47f0i 55 2 believe believe VBP cord-009753-6rg47f0i 55 3 PMO PMO NNP cord-009753-6rg47f0i 55 4 treatment treatment NN cord-009753-6rg47f0i 55 5 will will MD cord-009753-6rg47f0i 55 6 prove prove VB cord-009753-6rg47f0i 55 7 to to TO cord-009753-6rg47f0i 55 8 be be VB cord-009753-6rg47f0i 55 9 a a DT cord-009753-6rg47f0i 55 10 safe safe JJ cord-009753-6rg47f0i 55 11 and and CC cord-009753-6rg47f0i 55 12 reliable reliable JJ cord-009753-6rg47f0i 55 13 lung lung NN cord-009753-6rg47f0i 55 14 bypass bypass NN cord-009753-6rg47f0i 55 15 therapy therapy NN cord-009753-6rg47f0i 55 16 for for IN cord-009753-6rg47f0i 55 17 patients patient NNS cord-009753-6rg47f0i 55 18 with with IN cord-009753-6rg47f0i 55 19 severe severe JJ cord-009753-6rg47f0i 55 20 ARDS ARDS NNP cord-009753-6rg47f0i 55 21 who who WP cord-009753-6rg47f0i 55 22 can can MD cord-009753-6rg47f0i 55 23 not not RB cord-009753-6rg47f0i 55 24 tolerate tolerate VB cord-009753-6rg47f0i 55 25 the the DT cord-009753-6rg47f0i 55 26 significant significant JJ cord-009753-6rg47f0i 55 27 risk risk NN cord-009753-6rg47f0i 55 28 profile profile NN cord-009753-6rg47f0i 55 29 inherent inherent JJ cord-009753-6rg47f0i 55 30 to to IN cord-009753-6rg47f0i 55 31 ECMO ECMO NNP cord-009753-6rg47f0i 55 32 . . . cord-009753-6rg47f0i 56 1 As as IN cord-009753-6rg47f0i 56 2 we -PRON- PRP cord-009753-6rg47f0i 56 3 move move VBP cord-009753-6rg47f0i 56 4 toward toward IN cord-009753-6rg47f0i 56 5 clinical clinical JJ cord-009753-6rg47f0i 56 6 translation translation NN cord-009753-6rg47f0i 56 7 , , , cord-009753-6rg47f0i 56 8 we -PRON- PRP cord-009753-6rg47f0i 56 9 foresee foresee VBP cord-009753-6rg47f0i 56 10 the the DT cord-009753-6rg47f0i 56 11 implementation implementation NN cord-009753-6rg47f0i 56 12 of of IN cord-009753-6rg47f0i 56 13 PMO PMO NNP cord-009753-6rg47f0i 56 14 in in IN cord-009753-6rg47f0i 56 15 intensive intensive JJ cord-009753-6rg47f0i 56 16 care care NN cord-009753-6rg47f0i 56 17 units unit NNS cord-009753-6rg47f0i 56 18 , , , cord-009753-6rg47f0i 56 19 military military JJ cord-009753-6rg47f0i 56 20 combat combat NN cord-009753-6rg47f0i 56 21 settings setting NNS cord-009753-6rg47f0i 56 22 , , , cord-009753-6rg47f0i 56 23 and and CC cord-009753-6rg47f0i 56 24 even even RB cord-009753-6rg47f0i 56 25 space space NN cord-009753-6rg47f0i 56 26 exploration exploration NN cord-009753-6rg47f0i 56 27 vehicles vehicle NNS cord-009753-6rg47f0i 56 28 . . . cord-009753-6rg47f0i 57 1 Scale scale NN cord-009753-6rg47f0i 57 2 ranges range VBZ cord-009753-6rg47f0i 57 3 from from IN cord-009753-6rg47f0i 57 4 no no DT cord-009753-6rg47f0i 57 5 ( ( -LRB- cord-009753-6rg47f0i 57 6 0 0 NFP cord-009753-6rg47f0i 57 7 ) ) -RRB- cord-009753-6rg47f0i 57 8 and and CC cord-009753-6rg47f0i 57 9 severe severe JJ cord-009753-6rg47f0i 57 10 ( ( -LRB- cord-009753-6rg47f0i 57 11 3 3 CD cord-009753-6rg47f0i 57 12 ) ) -RRB- cord-009753-6rg47f0i 57 13 injury injury NN cord-009753-6rg47f0i 57 14 . . . cord-009753-6rg47f0i 58 1 a a DT cord-009753-6rg47f0i 58 2 One one CD cord-009753-6rg47f0i 58 3 rat rat NN cord-009753-6rg47f0i 58 4 suffered suffer VBD cord-009753-6rg47f0i 58 5 pulmonary pulmonary JJ cord-009753-6rg47f0i 58 6 injury injury NN cord-009753-6rg47f0i 58 7 during during IN cord-009753-6rg47f0i 58 8 euthanasia euthanasia NN cord-009753-6rg47f0i 58 9 , , , cord-009753-6rg47f0i 58 10 which which WDT cord-009753-6rg47f0i 58 11 artificially artificially RB cord-009753-6rg47f0i 58 12 increased increase VBD cord-009753-6rg47f0i 58 13 their -PRON- PRP$ cord-009753-6rg47f0i 58 14 score score NN cord-009753-6rg47f0i 58 15 . . . cord-009753-6rg47f0i 58 16 _SP cord-009753-6rg47f0i 59 1 Extracorporeal extracorporeal JJ cord-009753-6rg47f0i 59 2 Carbon Carbon NNP cord-009753-6rg47f0i 59 3 Dioxide dioxide NN cord-009753-6rg47f0i 59 4 Removal removal NN cord-009753-6rg47f0i 59 5 for for IN cord-009753-6rg47f0i 59 6 Patients patient NNS cord-009753-6rg47f0i 60 1 With with IN cord-009753-6rg47f0i 60 2 Acute acute JJ cord-009753-6rg47f0i 60 3 Respiratory Respiratory NNP cord-009753-6rg47f0i 60 4 Failure failure NN cord-009753-6rg47f0i 60 5 Secondary secondary JJ cord-009753-6rg47f0i 60 6 to to IN cord-009753-6rg47f0i 60 7 the the DT cord-009753-6rg47f0i 60 8 Acute acute JJ cord-009753-6rg47f0i 60 9 Respiratory Respiratory NNP cord-009753-6rg47f0i 60 10 Distress Distress NNP cord-009753-6rg47f0i 60 11 Syndrome Syndrome NNP cord-009753-6rg47f0i 60 12 : : : cord-009753-6rg47f0i 61 1 A a DT cord-009753-6rg47f0i 61 2 Systematic systematic JJ cord-009753-6rg47f0i 61 3 Review Review NNP cord-009753-6rg47f0i 61 4 Systemic systemic JJ cord-009753-6rg47f0i 61 5 Oxygen Oxygen NNP cord-009753-6rg47f0i 61 6 Delivery Delivery NNP cord-009753-6rg47f0i 61 7 by by IN cord-009753-6rg47f0i 61 8 Peritoneal peritoneal JJ cord-009753-6rg47f0i 61 9 Perfusion Perfusion NNP cord-009753-6rg47f0i 61 10 of of IN cord-009753-6rg47f0i 61 11 Oxygen Oxygen NNP cord-009753-6rg47f0i 61 12 Microbubbles Microbubbles NNP cord-009753-6rg47f0i 61 13 Intratracheal Intratracheal NNP cord-009753-6rg47f0i 61 14 Aerosolization Aerosolization NNP cord-009753-6rg47f0i 61 15 of of IN cord-009753-6rg47f0i 61 16 Endotoxin Endotoxin NNP cord-009753-6rg47f0i 61 17 ( ( -LRB- cord-009753-6rg47f0i 61 18 LPS LPS NNP cord-009753-6rg47f0i 61 19 ) ) -RRB- cord-009753-6rg47f0i 61 20 in in IN cord-009753-6rg47f0i 61 21 the the DT cord-009753-6rg47f0i 61 22 Rat rat NN cord-009753-6rg47f0i 61 23 : : : cord-009753-6rg47f0i 62 1 A a DT cord-009753-6rg47f0i 62 2 Comprehensive Comprehensive NNP cord-009753-6rg47f0i 62 3 Animal Animal NNP cord-009753-6rg47f0i 62 4 Model Model NNP cord-009753-6rg47f0i 62 5 to to IN cord-009753-6rg47f0i 62 6 Study Study NNP cord-009753-6rg47f0i 62 7 Adult Adult NNP cord-009753-6rg47f0i 62 8 ( ( -LRB- cord-009753-6rg47f0i 62 9 Acute acute NN cord-009753-6rg47f0i 62 10 ) ) -RRB- cord-009753-6rg47f0i 63 1 Respiratory respiratory JJ cord-009753-6rg47f0i 63 2 Distress Distress NNP cord-009753-6rg47f0i 63 3 Syndrome Syndrome NNP cord-009753-6rg47f0i 63 4 The the DT cord-009753-6rg47f0i 63 5 Effects effect NNS cord-009753-6rg47f0i 63 6 of of IN cord-009753-6rg47f0i 63 7 Ketamine Ketamine NNP cord-009753-6rg47f0i 63 8 , , , cord-009753-6rg47f0i 63 9 Midazolam Midazolam NNP cord-009753-6rg47f0i 63 10 and and CC cord-009753-6rg47f0i 63 11 Ketamine Ketamine NNP cord-009753-6rg47f0i 63 12 / / SYM cord-009753-6rg47f0i 63 13 Xylazine Xylazine NNP cord-009753-6rg47f0i 63 14 on on IN cord-009753-6rg47f0i 63 15 Acute Acute NNP cord-009753-6rg47f0i 63 16 Lung Lung NNP cord-009753-6rg47f0i 63 17 Injury injury NN cord-009753-6rg47f0i 63 18 Induced induce VBN cord-009753-6rg47f0i 63 19 by by IN cord-009753-6rg47f0i 63 20 A A NNP cord-009753-6rg47f0i 63 21 - - HYPH cord-009753-6rg47f0i 63 22 Naphthylthiourea Naphthylthiourea NNP cord-009753-6rg47f0i 63 23 in in IN cord-009753-6rg47f0i 63 24 Rats rat NNS cord-009753-6rg47f0i 64 1 We -PRON- PRP cord-009753-6rg47f0i 64 2 wish wish VBP cord-009753-6rg47f0i 64 3 to to TO cord-009753-6rg47f0i 64 4 thank thank VB cord-009753-6rg47f0i 64 5 UNL UNL NNP cord-009753-6rg47f0i 64 6 's 's POS cord-009753-6rg47f0i 64 7 Institutional Institutional NNP cord-009753-6rg47f0i 64 8 Animal Animal NNP cord-009753-6rg47f0i 64 9 Care Care NNP cord-009753-6rg47f0i 64 10 staff staff NN cord-009753-6rg47f0i 64 11 who who WP cord-009753-6rg47f0i 64 12 helped help VBD cord-009753-6rg47f0i 64 13 us -PRON- PRP cord-009753-6rg47f0i 64 14 in in IN cord-009753-6rg47f0i 64 15 performing perform VBG cord-009753-6rg47f0i 64 16 the the DT cord-009753-6rg47f0i 64 17 procedures procedure NNS cord-009753-6rg47f0i 64 18 and and CC cord-009753-6rg47f0i 64 19 for for IN cord-009753-6rg47f0i 64 20 caring care VBG cord-009753-6rg47f0i 64 21 for for IN cord-009753-6rg47f0i 64 22 the the DT cord-009753-6rg47f0i 64 23 animals animal NNS cord-009753-6rg47f0i 64 24 used use VBN cord-009753-6rg47f0i 64 25 in in IN cord-009753-6rg47f0i 64 26 this this DT cord-009753-6rg47f0i 64 27 study study NN cord-009753-6rg47f0i 64 28 . . . cord-009753-6rg47f0i 65 1 Funding funding NN cord-009753-6rg47f0i 65 2 was be VBD cord-009753-6rg47f0i 65 3 provided provide VBN cord-009753-6rg47f0i 65 4 by by IN cord-009753-6rg47f0i 65 5 UNO UNO NNP cord-009753-6rg47f0i 65 6 NASA NASA NNP cord-009753-6rg47f0i 65 7 Space Space NNP cord-009753-6rg47f0i 65 8 Grant Grant NNP cord-009753-6rg47f0i 65 9 No No NNP cord-009753-6rg47f0i 65 10 . . NN cord-009753-6rg47f0i 65 11 28648 28648 CD cord-009753-6rg47f0i 65 12 . . .