id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337923-1vbkttzx	Li, Xiao-Jun	Chemical Constituents and an Antineuroinflammatory Lignan, Savinin from the Roots of Acanthopanax henryi	2019-02-21		.txt	text/plain	3979	246	51	henryi have strong antioxidant and antiacetyl cholinesterase activities [6] , and the 80% methanol fraction of root bark and ciwujianoside C3, which was isolated from leaves of this plant, have significant antiinflammatory effect in lipopolysaccharide-(LPS-) induced RAW264.7 macrophage cells [5, 11] . henryi, we selected 13 compounds (compounds -, , , , , , , , and -) based on their number of publications, and these compounds were screened for anti-inflammatory effects, including the inhibition of NO and PGE 2 production, in LPS-stimulated BV2 microglial cells. The concentration required to inhibit the production of NO by 50% (IC 50 value) was calculated based on the concentrations of NO and PGE 2 released into the culture Figure 2 : The effect of compound on LPS-induced iNOS and COX-2 protein expression in BV2 microglial cells. henryi, suppressed NO and PGE 2 production in LPS-stimulated BV2 microglial cells and also inhibited the LPS-induced expression of the iNOS and COX-2 protein (Figure 2) .	./cache/cord-337923-1vbkttzx.txt	./txt/cord-337923-1vbkttzx.txt