id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311481-2awvmpyh	Kosukegawa, Ima	The proton pump inhibitor, lansoprazole, prevents the development of non-traumatic osteonecrosis of the femoral head: an experimental and prospective clinical trial	2020-01-14		.txt	text/plain	4725	226	53	OBJECTIVE: In the present study, we hypothesize that lansoprazole has the potential to suppress IRF7 activity and prevent corticosteroid-induced ONFH in rats. In the present study, we hypothesized that LPZ has the potential to suppress IRF7 and NF-κB, in the same manner as BAY11-7082, and so prevent corticosteroid-induced ONFH in rats. The present study showed that the co-treatment of LPZ with corticosteroids prevents the development of ONFH in experimental animals, as well as in patients with immune disease treated with corticosteroids. The results of the experimental study indicate that LPZ may also prevent the development of ONFH in patients with immune diseases needing corticosteroid treatment. The present study shows that the co-treatment of LPZ with corticosteroids prevents the development of ONFH through the suppression of IRF7 activity in rats. Nevertheless, we believe that LPZ is safe to use and could be effective in preventing osteonecrosis of the femoral head in patients needing corticosteroid treatment.	./cache/cord-311481-2awvmpyh.txt	./txt/cord-311481-2awvmpyh.txt