id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296258-8pc2p3az	Hwang, Eun-Ha	Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF) mediates innate immune responses in murine peritoneal mesothelial cells through TLR3 and TLR4 stimulation	2016-01-31		.txt	text/plain	5579	358	54	title: Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF) mediates innate immune responses in murine peritoneal mesothelial cells through TLR3 and TLR4 stimulation In the present study, we investigated the role of Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF), one of the two major TLRs–adaptor molecules, on innate immune response induced by TLR3 and TLR4 stimulation in murine peritoneal mesothelial cells (PMCs). When faced with an infection, mesothelial cells express specific surface markers that enable them to promote the migration of neutrophils, to interact with extracellular matrix proteins, to present antigens to immune cells, and to produce biologically important molecules such as proinflammatory cytokines, chemokines, and nitric oxide (NO) [6, 7] Toll-like receptors (TLRs) are type I transmembrane proteins and comprise an ectodomain, which contains leucine-rich repeats that mediate the recognition of pathogen-associated molecular patterns (PAMPs); a transmembrane region; and a cytosolic Toll/ IL-1 receptor (TIR) domain that activates downstream signaling pathways [8] .	./cache/cord-296258-8pc2p3az.txt	./txt/cord-296258-8pc2p3az.txt