id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-283427-fef9qsik	Kim, Gwang-Ho	Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines	2019-11-29		.txt	text/plain	3699	213	54	In our previous study, we established of minimal positive control conditions to ensure brain safety using experimental mice models during development of urgent vaccines before introducing to markets. In this study, we described that this module can be useful in applying a commercially available vaccine to a rapid and effective positive-control for brain safety assessment of an urgent vaccine. In brief, evidences for the BBB damage by commercially available vaccines (killed porcine genital respiratory syndrome vaccine vaccine and live canine parvovirus vaccine) were based on Evans blue EB permeability into brain parenchyma and mRNA expression of tight junctions (ZO-1 and Occludin) in the brain. However, when 2-fold concentrations of two vaccines stock solutions were injected, occludin mRNA expression was increased compared to the PBS group, but not significantly. In the present study, we confirmed that these established conditions and modules of the positive control that destroyed the BBB could be used to assess brain safety of commercial vaccines [1] .	./cache/cord-283427-fef9qsik.txt	./txt/cord-283427-fef9qsik.txt