id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257092-r11cgpvs	Wu, Fengjiao	CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation	2015-05-21		.txt	text/plain	6725	427	51	Furthermore, the bone marrow transfer experiments demonstrated that CXCR2 expression on CNS-residing cells is essential for cerebral endothelial activation and leukocyte recruitment. We observed reduced neutrophil infiltration and attenuated leukocyte-endothelial cell interactions in CXCR2 −/− and CXCL1 −/− mice following the intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS). To identify the source of functional CXCR2 that mediates leukocyte recruitment, we generated chimeric mice by transferring bone marrow cells between WT and (See figure on previous page.) Fig. 2 Chemokine levels and the effect of CXCR2 or CXCL1 deficiency on neutrophil recruitment to the brain parenchyma after i.c.v. LPS injection. Following stimulation with TNF-α or LPS, the cerebral endothelial cells, compared with astrocytes and microglia, also expressed much higher level of CXCR2 protein (Fig. 7D ). Our results demonstrate that CXCL1, an important factor secreted by astrocytes, also plays a critical role in leukocyte recruitment to the CNS by cooperating with CXCR2 expressed on cerebral endothelial cells.	./cache/cord-257092-r11cgpvs.txt	./txt/cord-257092-r11cgpvs.txt