id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-032564-0t5lr4z9	Moin, Abu Saleh Md	Pro-fibrotic M2 macrophage markers may increase the risk for COVID19 in type 2 diabetes with obesity()()	2020-09-16		.txt	text/plain	1052	62	44	5 We report here that LPS-related markers were associated with activated lung alveolar M2 macrophages in OT2D, with a reduction in plasma LBP as a surrogate marker of circulatory LPS elevation. Elevated plasma levels of TGF-β1, PDGF-β, MMP7 and MMP9 determined early in the course of COVID19 infection in a patient with OT2D may indicate potential risk for more severe disease. Moreover, it is also possible that, apart from alveolar macrophages, other cellular sources, for example lung epithelial cells [16] , arterial smooth muscle cells [17] , epithelial cells of glandular tissues like prostate [18] or bile duct epithelia [19] , might contribute to LPS-induced elevated plasma levels of those pro-fibrotic markers. In conclusion, in OT2D the lung epithelial barrier integrity is likely destabilized in response to fibroproliferative activity of elevated TGF-β1, PDGF-β, MMP7 or MMP9 derived from lung alveolar macrophages, increasing vulnerability to inhaled pathogens.	./cache/cord-032564-0t5lr4z9.txt	./txt/cord-032564-0t5lr4z9.txt