id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-013067-sic08gsg	Turzo, Maurizio	Inhibition of overexpressed Kv3.4 augments HPV in endotoxemic mice	2020-10-08		.txt	text/plain	4396	267	51	Inhibition of Kv3.4 with the specific blocker BDS-I increased HPV in isolated perfused endotoxemic mouse lungs. Extracts of total lung tissue from mice with LPS i.p. showed an increase of Kv3.4 gene expression (3.9 ± 0.5fold, n = 6, mean ± SEM, p < 0.05) ( Fig. 1 ) in comparison to 0.9% NaCl solution treated controls (1.0 ± 0.2-fold, normalized on 1, n = 6, means ± SEM). In order to test the role of Kv3.4 in the pulmonary vasculature, lungs of mice with and without endotoxemia were perfused with and without 50 nM of the Kv3.4 specific inhibitor BDS-I. Since Nav1.7 expression is not described in pulmonary arteries, it reduces the possibility that the effect by 50 nM BDS-I in the isolated perfused mouse lung are provoked via inhibition of Nav1.7. An isolated, perfused mouse lung model was used to study pulmonary vasoreactivity in response to acute hypoxia in LPS exposed mice.	./cache/cord-013067-sic08gsg.txt	./txt/cord-013067-sic08gsg.txt