id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009753-6rg47f0i	Legband, Nathan	The Treatment of Acute Respiratory Distress Syndrome in Rats With a Peritoneal Dosing System	2015-06-01		.txt	text/plain	1278	78	52	Current medical treatments for conditions involving an impaired respiratory system provide inefficient methods of delivering oxygen to the patient. Previously, we have shown that peritoneal membrane oxygenation (PMO) with OMBs is a possible treatment method in acute lung injury models [2] . Our study involves two phases: (1) development and characterization of the ARDS disease model in rats; (2) design and validation of ambulatory infusion device. Phase 2 is the development of an ambulatory delivery system that will infuse fluid to the rat's peritoneal cavity for treatment. We expect to be able to continuously dose saline, inert gas microbubbles (IMBs), and OMBs into the peritoneal cavity of four animals with the current PDS design. Based upon our previous animal experiments with lung injuries, we anticipate improved pulse oximetry, blood gases, and survivability in rats provided OMBs compared to those administered saline or IMBs. Intratracheal Aerosolization of Endotoxin (LPS) in the Rat: A Comprehensive Animal Model to Study Adult (Acute) Respiratory Distress Syndrome	./cache/cord-009753-6rg47f0i.txt	./txt/cord-009753-6rg47f0i.txt