id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006570-v4as5gde	Sukhotnik, Igor	Oral Insulin Up-regulates Toll-like Receptor 4 Expression and Enhances Intestinal Recovery Following Lipopolysaccharide-induced Gut Injury in a Rat	2007-10-13		.txt	text/plain	4069	206	44	title: Oral Insulin Up-regulates Toll-like Receptor 4 Expression and Enhances Intestinal Recovery Following Lipopolysaccharide-induced Gut Injury in a Rat LPS-INS animals showed a significantly greater bowel and mucosal weight in jejunum and ileum, mucosal DNA and protein in jejunum and ileum, villus height in ileum, crypt depth in jejunum and ileum, cell proliferation rates in jejunum, and significantly lower apoptotic index in ileum compared to LPSanimals. The purpose of this study was to evaluate the effects of oral insulin in preventing mucosal damage caused by LPS endotoxemia in a rat model, including its effect on enterocyte proliferation and death via apoptosis, and to determine whether alterations in Toll-like receptor 4-mediated signaling may occur during LPS endotoxemia and insulin administration. Oral insulin increases the stimulating effect of LPS on Toll-like receptor 4 expression in the proximal intestine, suggesting that TLR4 is not the mediator of injury in this model.	./cache/cord-006570-v4as5gde.txt	./txt/cord-006570-v4as5gde.txt