id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006318-9r51n241	Sideras, Paschalis	Activin, neutrophils, and inflammation: just coincidence?	2013-02-06		.txt	text/plain	12965	546	32	During the 26 years that have elapsed since its discovery, activin-A, a member of the transforming growth factor β super-family originally discovered from its capacity to stimulate follicle-stimulating hormone production by cultured pituitary gonadotropes, has been established as a key regulator of various fundamental biological processes, such as development, homeostasis, inflammation, and tissue remodeling. [92] that prophylactic and therapeutic treatment with follistatin could improve the survival rate of mice in three mouse colitis models, attenuate several pathology-associated parameters and upregulate proliferation of intestinal epithelial cells and tissue repair, improving thus the barrier function of the colonic mucosa, strongly supported the association between activin-A and colitis pathophysiology [92] . The combination of aggravated innate immunity, activation of the coagulation system, and alterations in molecular systems crucial for homeostasis, such as the surfactants in the lung, can collectively lead to acute necroptotic cell death which leads to the release of highly pro-inflammatory complexes of DAMPs and cytokines that can activate via a feed-forward like response further activation of the TLR signaling pathway and further production of activin-A.	./cache/cord-006318-9r51n241.txt	./txt/cord-006318-9r51n241.txt