id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004140-ujzrqzv3	Lu, Xiaying	Rolipram Protects Mice from Gram-negative Bacterium Escherichia coli-induced Inflammation and Septic Shock	2020-01-13		.txt	text/plain	3474	208	48	As a selective phosphodiesterase-4 inhibitor, rolipram also exhibits the abilities of inhibiting multiple pro-inflammatory cytokines production in macrophages and toxin-induced inflammation in mice. Therefore, the serum levels of multiple pro-inflammatory cytokines Male C57BL/6 mice were injected with different doses of rolipram (1 mg/kg, 5 mg/kg, and 10 mg/kg, i.p.) 1 hr before LPS injection. We demonstrate that rolipram may protect against LPS-induced inflammation and shock in mice, likely through the inhibition of the NF-κB and MAPK signaling pathways. We have found that rolipram inhibits pro-inflammatory cytokines and chemokines released by the administration of LPS, leading to the suppression of excessive inflammatory responses, cell adhesion and migration, and the further sequelae of shock and multiple organ failure in the mouse host. Our results indicated that rolipram suppresses LPS-induced ERK, JNK, and p38 MAPK phosphorylation in lung tissue, suggesting that the MAPK signaling pathway -as well as NF-κB -may mediate the anti-inflammatory actions of rolipram.	./cache/cord-004140-ujzrqzv3.txt	./txt/cord-004140-ujzrqzv3.txt