id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002165-blbaqbo7	Wu, Dongdong	Interferon Regulatory Factor-1 Mediates Alveolar Macrophage Pyroptosis During LPS-Induced Acute Lung Injury in Mice	2016-08-15		.txt	text/plain	4744	281	50	title: Interferon Regulatory Factor-1 Mediates Alveolar Macrophage Pyroptosis During LPS-Induced Acute Lung Injury in Mice Previously, we demonstrated that pyroptosis in alveolar macrophages (AMs) plays an essential role in lipopolysaccharide (LPS)-induced acute lung injury. Here, we show that the absence of interferon regulatory factor 1 (IRF-1) in genetic knock-out mice strongly abrogates pyroptosis in AMs and alleviates the LPS-induced lung injury and systemic inflammation. A previous study conducted by our group observed caspase-1 activation in AMs during the development of ALI/ ARDS, and further, that treatment with a specific caspase-1 inhibitor has been shown to reduce LPS-induced lung injury in mice (8) . In the present study, we showed that the absence of IRF-1 in genetic knockout mice strongly alleviates LPS-induced lung injury and abrogates its pyroptotic effects in AMs. These findings suggest that IRF-1 plays a key role in controlling caspase-1-dependent pyroptosis and inflammation, which is, in turn, a TLR4-dependent process.	./cache/cord-002165-blbaqbo7.txt	./txt/cord-002165-blbaqbo7.txt