id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001496-186k6t03	Yuan, Qing	Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats	2014-12-05		.txt	text/plain	5022	262	44	Lung injury was assessed by pulmonary histology, lung wet-weight to dry-weight (W/D) ratio, the number of myeloperoxidase (MPO) positive cells, immunohistochemical analysis of intercellular adhesion molecule-1 (ICAM-1), gene expression of ICAM-1, ultrastructure changes of pulmonary microvasculature, concentration of inflammatory markers and in plasma. RESULTS: Infusion of LPS induced lung injury, in vivo, as demonstrated by pulmonary edema with infiltration of neutrophils and hemorrhage, the increase in lung W/D ratio, the number of MPO positive cells, the level of inflammatory markers such as TNF-α, MCP-1 and IL-8, enhanced expression of ICAM-1 and ICAM-1 gene. CONCLUSIONS: These results indicate that Ginsenoside Rb1 attenuated LPS-induced lung injury through an inhibition of the inflammatory signaling pathway, besides the direct inhibitory effect on proinflammatory molecules. The goal of the present study was to clarify the effects of Ginsenoside Rb1 on LPS-induced rat lung injury and analyzed the detailed molecular mechanisms in vivo and in vitro.	./cache/cord-001496-186k6t03.txt	./txt/cord-001496-186k6t03.txt