id sid tid token lemma pos cord-342808-yonbowkb 1 1 key key JJ cord-342808-yonbowkb 1 2 : : : cord-342808-yonbowkb 1 3 cord-342808-yonbowkb cord-342808-yonbowkb NNP cord-342808-yonbowkb 2 1 authors author NNS cord-342808-yonbowkb 2 2 : : : cord-342808-yonbowkb 2 3 Francque Francque NNP cord-342808-yonbowkb 2 4 , , , cord-342808-yonbowkb 2 5 Sven Sven NNP cord-342808-yonbowkb 2 6 title title NN cord-342808-yonbowkb 2 7 : : : cord-342808-yonbowkb 2 8 Innovative innovative JJ cord-342808-yonbowkb 2 9 liver liver NN cord-342808-yonbowkb 2 10 research research NN cord-342808-yonbowkb 2 11 continues continue VBZ cord-342808-yonbowkb 2 12 during during IN cord-342808-yonbowkb 2 13 the the DT cord-342808-yonbowkb 2 14 current current JJ cord-342808-yonbowkb 2 15 pandemic pandemic NN cord-342808-yonbowkb 2 16 date date NN cord-342808-yonbowkb 2 17 : : : cord-342808-yonbowkb 2 18 2020 2020 CD cord-342808-yonbowkb 2 19 - - HYPH cord-342808-yonbowkb 2 20 05 05 CD cord-342808-yonbowkb 2 21 - - HYPH cord-342808-yonbowkb 2 22 24 24 CD cord-342808-yonbowkb 2 23 journal journal NN cord-342808-yonbowkb 2 24 : : : cord-342808-yonbowkb 3 1 JHEP JHEP NNP cord-342808-yonbowkb 4 1 Rep Rep NNP cord-342808-yonbowkb 4 2 DOI DOI NNP cord-342808-yonbowkb 4 3 : : : cord-342808-yonbowkb 4 4 10.1016 10.1016 CD cord-342808-yonbowkb 4 5 / / SYM cord-342808-yonbowkb 4 6 j.jhepr.2020.100121 j.jhepr.2020.100121 NN cord-342808-yonbowkb 4 7 sha sha NNP cord-342808-yonbowkb 4 8 : : : cord-342808-yonbowkb 5 1 1f8567445c5362034eda8e048134e27feefc1d3a 1f8567445c5362034eda8e048134e27feefc1d3a CD cord-342808-yonbowkb 5 2 doc_id doc_id CD cord-342808-yonbowkb 5 3 : : : cord-342808-yonbowkb 6 1 342808 342808 CD cord-342808-yonbowkb 6 2 cord_uid cord_uid NN cord-342808-yonbowkb 6 3 : : : cord-342808-yonbowkb 7 1 yonbowkb yonbowkb FW cord-342808-yonbowkb 7 2 nan nan NNP cord-342808-yonbowkb 8 1 Whilst whilst IN cord-342808-yonbowkb 8 2 the the DT cord-342808-yonbowkb 8 3 COVID-19 COVID-19 NNP cord-342808-yonbowkb 8 4 pandemic pandemic NN cord-342808-yonbowkb 8 5 runs run VBZ cord-342808-yonbowkb 8 6 its -PRON- PRP$ cord-342808-yonbowkb 8 7 devastating devastating JJ cord-342808-yonbowkb 8 8 course course NN cord-342808-yonbowkb 8 9 , , , cord-342808-yonbowkb 8 10 heavily heavily RB cord-342808-yonbowkb 8 11 impacting impact VBG cord-342808-yonbowkb 8 12 on on IN cord-342808-yonbowkb 8 13 the the DT cord-342808-yonbowkb 8 14 health health NN cord-342808-yonbowkb 8 15 and and CC cord-342808-yonbowkb 8 16 quality quality NN cord-342808-yonbowkb 8 17 of of IN cord-342808-yonbowkb 8 18 life life NN cord-342808-yonbowkb 8 19 ( ( -LRB- cord-342808-yonbowkb 8 20 QoL qol NN cord-342808-yonbowkb 8 21 ) ) -RRB- cord-342808-yonbowkb 8 22 of of IN cord-342808-yonbowkb 8 23 many many JJ cord-342808-yonbowkb 8 24 , , , cord-342808-yonbowkb 8 25 the the DT cord-342808-yonbowkb 8 26 scientific scientific JJ cord-342808-yonbowkb 8 27 community community NN cord-342808-yonbowkb 8 28 continues continue VBZ cord-342808-yonbowkb 8 29 to to TO cord-342808-yonbowkb 8 30 work work VB cord-342808-yonbowkb 8 31 hard hard RB cord-342808-yonbowkb 8 32 to to TO cord-342808-yonbowkb 8 33 reconcile reconcile VB cord-342808-yonbowkb 8 34 the the DT cord-342808-yonbowkb 8 35 need need NN cord-342808-yonbowkb 8 36 for for IN cord-342808-yonbowkb 8 37 new new JJ cord-342808-yonbowkb 8 38 knowledge knowledge NN cord-342808-yonbowkb 8 39 to to TO cord-342808-yonbowkb 8 40 fight fight VB cord-342808-yonbowkb 8 41 this this DT cord-342808-yonbowkb 8 42 unprecedented unprecedented JJ cord-342808-yonbowkb 8 43 threat threat NN cord-342808-yonbowkb 8 44 to to IN cord-342808-yonbowkb 8 45 individual individual JJ cord-342808-yonbowkb 8 46 and and CC cord-342808-yonbowkb 8 47 global global JJ cord-342808-yonbowkb 8 48 health health NN cord-342808-yonbowkb 8 49 , , , cord-342808-yonbowkb 8 50 the the DT cord-342808-yonbowkb 8 51 high high JJ cord-342808-yonbowkb 8 52 clinical clinical JJ cord-342808-yonbowkb 8 53 needs need NNS cord-342808-yonbowkb 8 54 , , , cord-342808-yonbowkb 8 55 as as RB cord-342808-yonbowkb 8 56 well well RB cord-342808-yonbowkb 8 57 as as IN cord-342808-yonbowkb 8 58 the the DT cord-342808-yonbowkb 8 59 continuous continuous JJ cord-342808-yonbowkb 8 60 need need NN cord-342808-yonbowkb 8 61 to to TO cord-342808-yonbowkb 8 62 invest invest VB cord-342808-yonbowkb 8 63 in in IN cord-342808-yonbowkb 8 64 research research NN cord-342808-yonbowkb 8 65 for for IN cord-342808-yonbowkb 8 66 the the DT cord-342808-yonbowkb 8 67 non non JJ cord-342808-yonbowkb 8 68 - - JJ cord-342808-yonbowkb 8 69 COVID-19related covid-19related JJ cord-342808-yonbowkb 8 70 diseases disease NNS cord-342808-yonbowkb 8 71 that that WDT cord-342808-yonbowkb 8 72 continue continue VBP cord-342808-yonbowkb 8 73 to to TO cord-342808-yonbowkb 8 74 impact impact VB cord-342808-yonbowkb 8 75 on on IN cord-342808-yonbowkb 8 76 our -PRON- PRP$ cord-342808-yonbowkb 8 77 populations population NNS cord-342808-yonbowkb 8 78 . . . cord-342808-yonbowkb 9 1 The the DT cord-342808-yonbowkb 9 2 editorial editorial JJ cord-342808-yonbowkb 9 3 team team NN cord-342808-yonbowkb 9 4 of of IN cord-342808-yonbowkb 9 5 JHEP JHEP NNP cord-342808-yonbowkb 9 6 Reports Reports NNPS cord-342808-yonbowkb 9 7 is be VBZ cord-342808-yonbowkb 9 8 therefore therefore RB cord-342808-yonbowkb 9 9 pleased pleased JJ cord-342808-yonbowkb 9 10 to to TO cord-342808-yonbowkb 9 11 present present VB cord-342808-yonbowkb 9 12 the the DT cord-342808-yonbowkb 9 13 next next JJ cord-342808-yonbowkb 9 14 issue issue NN cord-342808-yonbowkb 9 15 of of IN cord-342808-yonbowkb 9 16 the the DT cord-342808-yonbowkb 9 17 journal journal NN cord-342808-yonbowkb 9 18 on on IN cord-342808-yonbowkb 9 19 schedule schedule NN cord-342808-yonbowkb 9 20 . . . cord-342808-yonbowkb 10 1 First first RB cord-342808-yonbowkb 10 2 , , , cord-342808-yonbowkb 10 3 we -PRON- PRP cord-342808-yonbowkb 10 4 tackle tackle VBP cord-342808-yonbowkb 10 5 the the DT cord-342808-yonbowkb 10 6 COVID-19 covid-19 JJ cord-342808-yonbowkb 10 7 issue issue NN cord-342808-yonbowkb 10 8 by by IN cord-342808-yonbowkb 10 9 providing provide VBG cord-342808-yonbowkb 10 10 a a DT cord-342808-yonbowkb 10 11 key key JJ cord-342808-yonbowkb 10 12 position position NN cord-342808-yonbowkb 10 13 paper paper NN cord-342808-yonbowkb 10 14 that that WDT cord-342808-yonbowkb 10 15 comprehensively comprehensively RB cord-342808-yonbowkb 10 16 summarises summarise VBZ cord-342808-yonbowkb 10 17 our -PRON- PRP$ cord-342808-yonbowkb 10 18 current current JJ cord-342808-yonbowkb 10 19 knowledge knowledge NN cord-342808-yonbowkb 10 20 on on IN cord-342808-yonbowkb 10 21 how how WRB cord-342808-yonbowkb 10 22 COVID-19 covid-19 JJ cord-342808-yonbowkb 10 23 impacts impact NNS cord-342808-yonbowkb 10 24 on on IN cord-342808-yonbowkb 10 25 the the DT cord-342808-yonbowkb 10 26 liver liver NN cord-342808-yonbowkb 10 27 , , , cord-342808-yonbowkb 10 28 how how WRB cord-342808-yonbowkb 10 29 preexisting preexisting JJ cord-342808-yonbowkb 10 30 liver liver NN cord-342808-yonbowkb 10 31 disease disease NN cord-342808-yonbowkb 10 32 might may MD cord-342808-yonbowkb 10 33 impact impact VB cord-342808-yonbowkb 10 34 on on IN cord-342808-yonbowkb 10 35 Covid-19 covid-19 NN cord-342808-yonbowkb 10 36 infections infection NNS cord-342808-yonbowkb 10 37 and and CC cord-342808-yonbowkb 10 38 how how WRB cord-342808-yonbowkb 10 39 to to TO cord-342808-yonbowkb 10 40 continue continue VB cord-342808-yonbowkb 10 41 to to TO cord-342808-yonbowkb 10 42 ensure ensure VB cord-342808-yonbowkb 10 43 care care NN cord-342808-yonbowkb 10 44 for for IN cord-342808-yonbowkb 10 45 patients patient NNS cord-342808-yonbowkb 10 46 with with IN cord-342808-yonbowkb 10 47 acute acute JJ cord-342808-yonbowkb 10 48 and and CC cord-342808-yonbowkb 10 49 chronic chronic JJ cord-342808-yonbowkb 10 50 liver liver NN cord-342808-yonbowkb 10 51 disease disease NN cord-342808-yonbowkb 10 52 in in IN cord-342808-yonbowkb 10 53 the the DT cord-342808-yonbowkb 10 54 current current JJ cord-342808-yonbowkb 10 55 context context NN cord-342808-yonbowkb 10 56 . . . cord-342808-yonbowkb 11 1 1 1 LS cord-342808-yonbowkb 12 1 This this DT cord-342808-yonbowkb 12 2 document document NN cord-342808-yonbowkb 12 3 is be VBZ cord-342808-yonbowkb 12 4 a a DT cord-342808-yonbowkb 12 5 joint joint JJ cord-342808-yonbowkb 12 6 effort effort NN cord-342808-yonbowkb 12 7 of of IN cord-342808-yonbowkb 12 8 the the DT cord-342808-yonbowkb 12 9 European European NNP cord-342808-yonbowkb 12 10 Association Association NNP cord-342808-yonbowkb 12 11 for for IN cord-342808-yonbowkb 12 12 the the DT cord-342808-yonbowkb 12 13 Study Study NNP cord-342808-yonbowkb 12 14 of of IN cord-342808-yonbowkb 12 15 the the DT cord-342808-yonbowkb 12 16 Liver liver NN cord-342808-yonbowkb 12 17 and and CC cord-342808-yonbowkb 12 18 the the DT cord-342808-yonbowkb 12 19 European European NNP cord-342808-yonbowkb 12 20 Society Society NNP cord-342808-yonbowkb 12 21 of of IN cord-342808-yonbowkb 12 22 Clinical Clinical NNP cord-342808-yonbowkb 12 23 Microbiology Microbiology NNP cord-342808-yonbowkb 12 24 and and CC cord-342808-yonbowkb 12 25 Infectious Infectious NNP cord-342808-yonbowkb 12 26 Diseases Diseases NNPS cord-342808-yonbowkb 12 27 and and CC cord-342808-yonbowkb 12 28 gives give VBZ cord-342808-yonbowkb 12 29 guidance guidance NN cord-342808-yonbowkb 12 30 regarding regard VBG cord-342808-yonbowkb 12 31 the the DT cord-342808-yonbowkb 12 32 burning burn VBG cord-342808-yonbowkb 12 33 issues issue NNS cord-342808-yonbowkb 12 34 . . . cord-342808-yonbowkb 13 1 Patients patient NNS cord-342808-yonbowkb 13 2 with with IN cord-342808-yonbowkb 13 3 pre pre JJ cord-342808-yonbowkb 13 4 - - JJ cord-342808-yonbowkb 13 5 existing existing JJ cord-342808-yonbowkb 13 6 medical medical JJ cord-342808-yonbowkb 13 7 conditions condition NNS cord-342808-yonbowkb 13 8 are be VBP cord-342808-yonbowkb 13 9 regarded regard VBN cord-342808-yonbowkb 13 10 as as IN cord-342808-yonbowkb 13 11 populations population NNS cord-342808-yonbowkb 13 12 at at IN cord-342808-yonbowkb 13 13 risk risk NN cord-342808-yonbowkb 13 14 of of IN cord-342808-yonbowkb 13 15 a a DT cord-342808-yonbowkb 13 16 severe severe JJ cord-342808-yonbowkb 13 17 disease disease NN cord-342808-yonbowkb 13 18 course course NN cord-342808-yonbowkb 13 19 , , , cord-342808-yonbowkb 13 20 but but CC cord-342808-yonbowkb 13 21 it -PRON- PRP cord-342808-yonbowkb 13 22 is be VBZ cord-342808-yonbowkb 13 23 currently currently RB cord-342808-yonbowkb 13 24 unclear unclear JJ cord-342808-yonbowkb 13 25 to to TO cord-342808-yonbowkb 13 26 what what WDT cord-342808-yonbowkb 13 27 extent extent NN cord-342808-yonbowkb 13 28 chronic chronic JJ cord-342808-yonbowkb 13 29 liver liver NN cord-342808-yonbowkb 13 30 diseases disease NNS cord-342808-yonbowkb 13 31 should should MD cord-342808-yonbowkb 13 32 be be VB cord-342808-yonbowkb 13 33 considered consider VBN cord-342808-yonbowkb 13 34 as as IN cord-342808-yonbowkb 13 35 risk risk NN cord-342808-yonbowkb 13 36 factors factor NNS cord-342808-yonbowkb 13 37 . . . cord-342808-yonbowkb 14 1 Patients patient NNS cord-342808-yonbowkb 14 2 with with IN cord-342808-yonbowkb 14 3 advanced advanced JJ cord-342808-yonbowkb 14 4 liver liver NN cord-342808-yonbowkb 14 5 disease disease NN cord-342808-yonbowkb 14 6 as as RB cord-342808-yonbowkb 14 7 well well RB cord-342808-yonbowkb 14 8 as as IN cord-342808-yonbowkb 14 9 liver liver NN cord-342808-yonbowkb 14 10 transplant transplant NN cord-342808-yonbowkb 14 11 patients patient NNS cord-342808-yonbowkb 14 12 likely likely RB cord-342808-yonbowkb 14 13 represent represent VBP cord-342808-yonbowkb 14 14 vulnerable vulnerable JJ cord-342808-yonbowkb 14 15 patient patient JJ cord-342808-yonbowkb 14 16 cohorts cohort NNS cord-342808-yonbowkb 14 17 with with IN cord-342808-yonbowkb 14 18 an an DT cord-342808-yonbowkb 14 19 increased increase VBN cord-342808-yonbowkb 14 20 risk risk NN cord-342808-yonbowkb 14 21 of of IN cord-342808-yonbowkb 14 22 infection infection NN cord-342808-yonbowkb 14 23 and/or and/or CC cord-342808-yonbowkb 14 24 a a DT cord-342808-yonbowkb 14 25 severe severe JJ cord-342808-yonbowkb 14 26 course course NN cord-342808-yonbowkb 14 27 of of IN cord-342808-yonbowkb 14 28 COVID-19 covid-19 NN cord-342808-yonbowkb 14 29 . . . cord-342808-yonbowkb 15 1 Furthermore furthermore RB cord-342808-yonbowkb 15 2 , , , cord-342808-yonbowkb 15 3 an an DT cord-342808-yonbowkb 15 4 unusual unusual JJ cord-342808-yonbowkb 15 5 allocation allocation NN cord-342808-yonbowkb 15 6 of of IN cord-342808-yonbowkb 15 7 healthcare healthcare NN cord-342808-yonbowkb 15 8 resources resource NNS cord-342808-yonbowkb 15 9 is be VBZ cord-342808-yonbowkb 15 10 currently currently RB cord-342808-yonbowkb 15 11 required require VBN cord-342808-yonbowkb 15 12 in in IN cord-342808-yonbowkb 15 13 virtually virtually RB cord-342808-yonbowkb 15 14 all all DT cord-342808-yonbowkb 15 15 countries country NNS cord-342808-yonbowkb 15 16 around around IN cord-342808-yonbowkb 15 17 the the DT cord-342808-yonbowkb 15 18 world world NN cord-342808-yonbowkb 15 19 . . . cord-342808-yonbowkb 16 1 This this DT cord-342808-yonbowkb 16 2 may may MD cord-342808-yonbowkb 16 3 negatively negatively RB cord-342808-yonbowkb 16 4 impact impact VB cord-342808-yonbowkb 16 5 the the DT cord-342808-yonbowkb 16 6 care care NN cord-342808-yonbowkb 16 7 of of IN cord-342808-yonbowkb 16 8 patients patient NNS cord-342808-yonbowkb 16 9 with with IN cord-342808-yonbowkb 16 10 chronic chronic JJ cord-342808-yonbowkb 16 11 liver liver NN cord-342808-yonbowkb 16 12 disease disease NN cord-342808-yonbowkb 16 13 who who WP cord-342808-yonbowkb 16 14 continue continue VBP cord-342808-yonbowkb 16 15 to to TO cord-342808-yonbowkb 16 16 require require VB cord-342808-yonbowkb 16 17 medical medical JJ cord-342808-yonbowkb 16 18 attention attention NN cord-342808-yonbowkb 16 19 . . . cord-342808-yonbowkb 17 1 This this DT cord-342808-yonbowkb 17 2 position position NN cord-342808-yonbowkb 17 3 paper paper NN cord-342808-yonbowkb 17 4 offers offer VBZ cord-342808-yonbowkb 17 5 guidance guidance NN cord-342808-yonbowkb 17 6 on on IN cord-342808-yonbowkb 17 7 how how WRB cord-342808-yonbowkb 17 8 to to TO cord-342808-yonbowkb 17 9 balance balance VB cord-342808-yonbowkb 17 10 the the DT cord-342808-yonbowkb 17 11 need need NN cord-342808-yonbowkb 17 12 to to TO cord-342808-yonbowkb 17 13 avoid avoid VB cord-342808-yonbowkb 17 14 nosocomial nosocomial JJ cord-342808-yonbowkb 17 15 dissemination dissemination NN cord-342808-yonbowkb 17 16 of of IN cord-342808-yonbowkb 17 17 the the DT cord-342808-yonbowkb 17 18 virus virus NN cord-342808-yonbowkb 17 19 to to IN cord-342808-yonbowkb 17 20 patients patient NNS cord-342808-yonbowkb 17 21 and and CC cord-342808-yonbowkb 17 22 healthcare healthcare NN cord-342808-yonbowkb 17 23 providers provider NNS cord-342808-yonbowkb 17 24 , , , cord-342808-yonbowkb 17 25 whilst whilst IN cord-342808-yonbowkb 17 26 at at IN cord-342808-yonbowkb 17 27 the the DT cord-342808-yonbowkb 17 28 same same JJ cord-342808-yonbowkb 17 29 time time NN cord-342808-yonbowkb 17 30 maintaining maintain VBG cord-342808-yonbowkb 17 31 a a DT cord-342808-yonbowkb 17 32 high high JJ cord-342808-yonbowkb 17 33 standard standard NN cord-342808-yonbowkb 17 34 of of IN cord-342808-yonbowkb 17 35 care care NN cord-342808-yonbowkb 17 36 for for IN cord-342808-yonbowkb 17 37 patients patient NNS cord-342808-yonbowkb 17 38 who who WP cord-342808-yonbowkb 17 39 require require VBP cord-342808-yonbowkb 17 40 immediate immediate JJ cord-342808-yonbowkb 17 41 and and CC cord-342808-yonbowkb 17 42 continued continued JJ cord-342808-yonbowkb 17 43 medical medical JJ cord-342808-yonbowkb 17 44 attention attention NN cord-342808-yonbowkb 17 45 . . . cord-342808-yonbowkb 18 1 The the DT cord-342808-yonbowkb 18 2 question question NN cord-342808-yonbowkb 18 3 of of IN cord-342808-yonbowkb 18 4 whether whether IN cord-342808-yonbowkb 18 5 nucleos(t)ide nucleos(t)ide JJ cord-342808-yonbowkb 18 6 analogues analogue NNS cord-342808-yonbowkb 18 7 ( ( -LRB- cord-342808-yonbowkb 18 8 NUCs nuc NNS cord-342808-yonbowkb 18 9 ) ) -RRB- cord-342808-yonbowkb 18 10 can can MD cord-342808-yonbowkb 18 11 be be VB cord-342808-yonbowkb 18 12 safely safely RB cord-342808-yonbowkb 18 13 discontinued discontinue VBN cord-342808-yonbowkb 18 14 in in IN cord-342808-yonbowkb 18 15 certain certain JJ cord-342808-yonbowkb 18 16 patients patient NNS cord-342808-yonbowkb 18 17 with with IN cord-342808-yonbowkb 18 18 chronic chronic JJ cord-342808-yonbowkb 18 19 hepatitis hepatitis NN cord-342808-yonbowkb 18 20 B B NNP cord-342808-yonbowkb 18 21 remains remain VBZ cord-342808-yonbowkb 18 22 a a DT cord-342808-yonbowkb 18 23 matter matter NN cord-342808-yonbowkb 18 24 of of IN cord-342808-yonbowkb 18 25 debate debate NN cord-342808-yonbowkb 18 26 . . . cord-342808-yonbowkb 19 1 One one CD cord-342808-yonbowkb 19 2 of of IN cord-342808-yonbowkb 19 3 the the DT cord-342808-yonbowkb 19 4 factors factor NNS cord-342808-yonbowkb 19 5 that that WDT cord-342808-yonbowkb 19 6 could could MD cord-342808-yonbowkb 19 7 potentially potentially RB cord-342808-yonbowkb 19 8 allow allow VB cord-342808-yonbowkb 19 9 for for IN cord-342808-yonbowkb 19 10 the the DT cord-342808-yonbowkb 19 11 safe safe JJ cord-342808-yonbowkb 19 12 withdrawal withdrawal NN cord-342808-yonbowkb 19 13 of of IN cord-342808-yonbowkb 19 14 NUCs nuc NNS cord-342808-yonbowkb 19 15 is be VBZ cord-342808-yonbowkb 19 16 the the DT cord-342808-yonbowkb 19 17 depletion depletion NN cord-342808-yonbowkb 19 18 of of IN cord-342808-yonbowkb 19 19 cccDNA cccdna NN cord-342808-yonbowkb 19 20 that that WDT cord-342808-yonbowkb 19 21 might may MD cord-342808-yonbowkb 19 22 occur occur VB cord-342808-yonbowkb 19 23 with with IN cord-342808-yonbowkb 19 24 long long JJ cord-342808-yonbowkb 19 25 - - HYPH cord-342808-yonbowkb 19 26 term term NN cord-342808-yonbowkb 19 27 treatment treatment NN cord-342808-yonbowkb 19 28 . . . cord-342808-yonbowkb 20 1 In in IN cord-342808-yonbowkb 20 2 the the DT cord-342808-yonbowkb 20 3 current current JJ cord-342808-yonbowkb 20 4 issue issue NN cord-342808-yonbowkb 20 5 of of IN cord-342808-yonbowkb 20 6 JHEP JHEP NNP cord-342808-yonbowkb 20 7 Reports Reports NNPS cord-342808-yonbowkb 20 8 , , , cord-342808-yonbowkb 20 9 Lai Lai NNP cord-342808-yonbowkb 20 10 et et FW cord-342808-yonbowkb 20 11 al al NNP cord-342808-yonbowkb 20 12 . . . cord-342808-yonbowkb 21 1 report report VB cord-342808-yonbowkb 21 2 that that IN cord-342808-yonbowkb 21 3 viral viral JJ cord-342808-yonbowkb 21 4 rebound rebound NN cord-342808-yonbowkb 21 5 occurred occur VBD cord-342808-yonbowkb 21 6 in in IN cord-342808-yonbowkb 21 7 most most JJS cord-342808-yonbowkb 21 8 cases case NNS cord-342808-yonbowkb 21 9 following follow VBG cord-342808-yonbowkb 21 10 NUC NUC NNP cord-342808-yonbowkb 21 11 cessation cessation NN cord-342808-yonbowkb 21 12 in in IN cord-342808-yonbowkb 21 13 a a DT cord-342808-yonbowkb 21 14 series series NN cord-342808-yonbowkb 21 15 of of IN cord-342808-yonbowkb 21 16 19 19 CD cord-342808-yonbowkb 21 17 patients patient NNS cord-342808-yonbowkb 21 18 with with IN cord-342808-yonbowkb 21 19 undetectable undetectable JJ cord-342808-yonbowkb 21 20 intrahepatic intrahepatic JJ cord-342808-yonbowkb 21 21 cccDNA cccDNA NNP cord-342808-yonbowkb 21 22 ( ( -LRB- cord-342808-yonbowkb 21 23 covalently covalently RB cord-342808-yonbowkb 21 24 closed closed JJ cord-342808-yonbowkb 21 25 circular circular JJ cord-342808-yonbowkb 21 26 DNA dna NN cord-342808-yonbowkb 21 27 ) ) -RRB- cord-342808-yonbowkb 21 28 . . . cord-342808-yonbowkb 22 1 2 2 LS cord-342808-yonbowkb 23 1 To to TO cord-342808-yonbowkb 23 2 what what WDT cord-342808-yonbowkb 23 3 extent extent NN cord-342808-yonbowkb 23 4 the the DT cord-342808-yonbowkb 23 5 determination determination NN cord-342808-yonbowkb 23 6 of of IN cord-342808-yonbowkb 23 7 cccDNA cccDNA NNP cord-342808-yonbowkb 23 8 on on IN cord-342808-yonbowkb 23 9 liver liver NN cord-342808-yonbowkb 23 10 biopsy biopsy NN cord-342808-yonbowkb 23 11 can can MD cord-342808-yonbowkb 23 12 reliably reliably RB cord-342808-yonbowkb 23 13 reflect reflect VB cord-342808-yonbowkb 23 14 liver liver NN cord-342808-yonbowkb 24 1 cccDNA cccDNA NNP cord-342808-yonbowkb 24 2 depletion depletion NN cord-342808-yonbowkb 24 3 is be VBZ cord-342808-yonbowkb 24 4 obviously obviously RB cord-342808-yonbowkb 24 5 questionable questionable JJ cord-342808-yonbowkb 24 6 , , , cord-342808-yonbowkb 24 7 but but CC cord-342808-yonbowkb 24 8 this this DT cord-342808-yonbowkb 24 9 study study NN cord-342808-yonbowkb 24 10 adds add VBZ cord-342808-yonbowkb 24 11 to to IN cord-342808-yonbowkb 24 12 the the DT cord-342808-yonbowkb 24 13 growing grow VBG cord-342808-yonbowkb 24 14 knowledge knowledge NN cord-342808-yonbowkb 24 15 on on IN cord-342808-yonbowkb 24 16 how how WRB cord-342808-yonbowkb 24 17 to to TO cord-342808-yonbowkb 24 18 handle handle VB cord-342808-yonbowkb 24 19 patients patient NNS cord-342808-yonbowkb 24 20 following follow VBG cord-342808-yonbowkb 24 21 successful successful JJ cord-342808-yonbowkb 24 22 NUC nuc NN cord-342808-yonbowkb 24 23 treatment treatment NN cord-342808-yonbowkb 24 24 . . . cord-342808-yonbowkb 25 1 Van Van NNP cord-342808-yonbowkb 25 2 Hees Hees NNP cord-342808-yonbowkb 25 3 et et NNP cord-342808-yonbowkb 25 4 al al NNP cord-342808-yonbowkb 25 5 . . . cord-342808-yonbowkb 26 1 3 3 LS cord-342808-yonbowkb 26 2 also also RB cord-342808-yonbowkb 26 3 reported report VBD cord-342808-yonbowkb 26 4 a a DT cord-342808-yonbowkb 26 5 > > XX cord-342808-yonbowkb 26 6 50 50 CD cord-342808-yonbowkb 26 7 % % NN cord-342808-yonbowkb 26 8 rebound rebound NN cord-342808-yonbowkb 26 9 rate rate NN cord-342808-yonbowkb 26 10 after after IN cord-342808-yonbowkb 26 11 treatment treatment NN cord-342808-yonbowkb 26 12 cessation cessation NN cord-342808-yonbowkb 26 13 in in IN cord-342808-yonbowkb 26 14 Caucasian caucasian JJ cord-342808-yonbowkb 26 15 patients patient NNS cord-342808-yonbowkb 26 16 with with IN cord-342808-yonbowkb 26 17 HBeAg hbeag CD cord-342808-yonbowkb 26 18 seroconversion seroconversion NN cord-342808-yonbowkb 26 19 , , , cord-342808-yonbowkb 26 20 with with IN cord-342808-yonbowkb 26 21 potentially potentially RB cord-342808-yonbowkb 26 22 fatal fatal JJ cord-342808-yonbowkb 26 23 outcomes outcome NNS cord-342808-yonbowkb 26 24 . . . cord-342808-yonbowkb 27 1 The the DT cord-342808-yonbowkb 27 2 study study NN cord-342808-yonbowkb 27 3 of of IN cord-342808-yonbowkb 27 4 Lai Lai NNP cord-342808-yonbowkb 27 5 et et FW cord-342808-yonbowkb 27 6 al al NNP cord-342808-yonbowkb 27 7 . . NNP cord-342808-yonbowkb 27 8 adds add VBZ cord-342808-yonbowkb 27 9 a a DT cord-342808-yonbowkb 27 10 note note NN cord-342808-yonbowkb 27 11 of of IN cord-342808-yonbowkb 27 12 caution caution NN cord-342808-yonbowkb 27 13 regarding regard VBG cord-342808-yonbowkb 27 14 NUC NUC NNP cord-342808-yonbowkb 27 15 cessation cessation NN cord-342808-yonbowkb 27 16 , , , cord-342808-yonbowkb 27 17 but but CC cord-342808-yonbowkb 27 18 unfortunately unfortunately RB cord-342808-yonbowkb 27 19 it -PRON- PRP cord-342808-yonbowkb 27 20 does do VBZ cord-342808-yonbowkb 27 21 not not RB cord-342808-yonbowkb 27 22 fill fill VB cord-342808-yonbowkb 27 23 the the DT cord-342808-yonbowkb 27 24 unmet unmet JJ cord-342808-yonbowkb 27 25 need need NN cord-342808-yonbowkb 27 26 of of IN cord-342808-yonbowkb 27 27 identifying identify VBG cord-342808-yonbowkb 27 28 reliable reliable JJ cord-342808-yonbowkb 27 29 predictors predictor NNS cord-342808-yonbowkb 27 30 for for IN cord-342808-yonbowkb 27 31 the the DT cord-342808-yonbowkb 27 32 safe safe JJ cord-342808-yonbowkb 27 33 discontinuation discontinuation NN cord-342808-yonbowkb 27 34 of of IN cord-342808-yonbowkb 27 35 NUCs nuc NNS cord-342808-yonbowkb 27 36 . . . cord-342808-yonbowkb 28 1 Whilst whilst IN cord-342808-yonbowkb 28 2 hepatitis hepatitis NN cord-342808-yonbowkb 28 3 C C NNP cord-342808-yonbowkb 28 4 has have VBZ cord-342808-yonbowkb 28 5 been be VBN cord-342808-yonbowkb 28 6 successfully successfully RB cord-342808-yonbowkb 28 7 tackled tackle VBN cord-342808-yonbowkb 28 8 in in IN cord-342808-yonbowkb 28 9 the the DT cord-342808-yonbowkb 28 10 last last JJ cord-342808-yonbowkb 28 11 decade decade NN cord-342808-yonbowkb 28 12 , , , cord-342808-yonbowkb 28 13 hepatitis hepatitis NN cord-342808-yonbowkb 28 14 B B NNP cord-342808-yonbowkb 28 15 and and CC cord-342808-yonbowkb 28 16 hepatitis hepatitis NNP cord-342808-yonbowkb 28 17 B B NNP cord-342808-yonbowkb 28 18 - - HYPH cord-342808-yonbowkb 28 19 D D NNP cord-342808-yonbowkb 28 20 coinfection coinfection NN cord-342808-yonbowkb 28 21 continue continue VBP cord-342808-yonbowkb 28 22 to to TO cord-342808-yonbowkb 28 23 challenge challenge VB cord-342808-yonbowkb 28 24 the the DT cord-342808-yonbowkb 28 25 hepatology hepatology NN cord-342808-yonbowkb 28 26 community community NN cord-342808-yonbowkb 28 27 , , , cord-342808-yonbowkb 28 28 as as IN cord-342808-yonbowkb 28 29 many many JJ cord-342808-yonbowkb 28 30 knowledge knowledge NN cord-342808-yonbowkb 28 31 gaps gap NNS cord-342808-yonbowkb 28 32 persist persist VBP cord-342808-yonbowkb 28 33 and and CC cord-342808-yonbowkb 28 34 viral viral JJ cord-342808-yonbowkb 28 35 eradication eradication NN cord-342808-yonbowkb 28 36 is be VBZ cord-342808-yonbowkb 28 37 rarely rarely RB cord-342808-yonbowkb 28 38 achieved achieve VBN cord-342808-yonbowkb 28 39 in in IN cord-342808-yonbowkb 28 40 hepatitis hepatitis NN cord-342808-yonbowkb 28 41 B B NNP cord-342808-yonbowkb 28 42 , , , cord-342808-yonbowkb 28 43 whilst whilst IN cord-342808-yonbowkb 28 44 the the DT cord-342808-yonbowkb 28 45 treatment treatment NN cord-342808-yonbowkb 28 46 of of IN cord-342808-yonbowkb 28 47 hepatitis hepatitis NN cord-342808-yonbowkb 28 48 D D NNP cord-342808-yonbowkb 28 49 is be VBZ cord-342808-yonbowkb 28 50 even even RB cord-342808-yonbowkb 28 51 more more RBR cord-342808-yonbowkb 28 52 challenging challenging JJ cord-342808-yonbowkb 28 53 . . . cord-342808-yonbowkb 29 1 The the DT cord-342808-yonbowkb 29 2 complex complex JJ cord-342808-yonbowkb 29 3 interaction interaction NN cord-342808-yonbowkb 29 4 between between IN cord-342808-yonbowkb 29 5 the the DT cord-342808-yonbowkb 29 6 virus virus NN cord-342808-yonbowkb 29 7 and and CC cord-342808-yonbowkb 29 8 host host NN cord-342808-yonbowkb 29 9 immune immune JJ cord-342808-yonbowkb 29 10 system system NN cord-342808-yonbowkb 29 11 is be VBZ cord-342808-yonbowkb 29 12 incompletely incompletely RB cord-342808-yonbowkb 29 13 understood understand VBN cord-342808-yonbowkb 29 14 , , , cord-342808-yonbowkb 29 15 which which WDT cord-342808-yonbowkb 29 16 hampers hamper VBZ cord-342808-yonbowkb 29 17 the the DT cord-342808-yonbowkb 29 18 development development NN cord-342808-yonbowkb 29 19 of of IN cord-342808-yonbowkb 29 20 efficacious efficacious JJ cord-342808-yonbowkb 29 21 treatments treatment NNS cord-342808-yonbowkb 29 22 . . . cord-342808-yonbowkb 30 1 4 4 LS cord-342808-yonbowkb 31 1 The the DT cord-342808-yonbowkb 31 2 development development NN cord-342808-yonbowkb 31 3 of of IN cord-342808-yonbowkb 31 4 animal animal NN cord-342808-yonbowkb 31 5 models model NNS cord-342808-yonbowkb 31 6 that that WDT cord-342808-yonbowkb 31 7 reliably reliably RB cord-342808-yonbowkb 31 8 mimic mimic VBP cord-342808-yonbowkb 31 9 the the DT cord-342808-yonbowkb 31 10 infection infection NN cord-342808-yonbowkb 31 11 in in IN cord-342808-yonbowkb 31 12 patients patient NNS cord-342808-yonbowkb 31 13 is be VBZ cord-342808-yonbowkb 31 14 particularly particularly RB cord-342808-yonbowkb 31 15 challenging challenging JJ cord-342808-yonbowkb 31 16 . . . cord-342808-yonbowkb 32 1 Usai Usai NNP cord-342808-yonbowkb 32 2 et et NNP cord-342808-yonbowkb 32 3 al al NNP cord-342808-yonbowkb 32 4 . . . cord-342808-yonbowkb 33 1 present present VB cord-342808-yonbowkb 33 2 their -PRON- PRP$ cord-342808-yonbowkb 33 3 results result NNS cord-342808-yonbowkb 33 4 on on IN cord-342808-yonbowkb 33 5 a a DT cord-342808-yonbowkb 33 6 large large JJ cord-342808-yonbowkb 33 7 and and CC cord-342808-yonbowkb 33 8 comprehensive comprehensive JJ cord-342808-yonbowkb 33 9 study study NN cord-342808-yonbowkb 33 10 on on IN cord-342808-yonbowkb 33 11 the the DT cord-342808-yonbowkb 33 12 immunological immunological JJ cord-342808-yonbowkb 33 13 mechanisms mechanism NNS cord-342808-yonbowkb 33 14 driving drive VBG cord-342808-yonbowkb 33 15 disease disease NN cord-342808-yonbowkb 33 16 progression progression NN cord-342808-yonbowkb 33 17 in in IN cord-342808-yonbowkb 33 18 hepatitis hepatitis NNP cord-342808-yonbowkb 33 19 B B NNP cord-342808-yonbowkb 33 20 - - HYPH cord-342808-yonbowkb 33 21 D D NNP cord-342808-yonbowkb 33 22 coinfection coinfection NN cord-342808-yonbowkb 33 23 . . . cord-342808-yonbowkb 34 1 5 5 LS cord-342808-yonbowkb 35 1 In in IN cord-342808-yonbowkb 35 2 an an DT cord-342808-yonbowkb 35 3 adeno adeno NN cord-342808-yonbowkb 35 4 - - HYPH cord-342808-yonbowkb 35 5 associated associate VBN cord-342808-yonbowkb 35 6 vector vector NN cord-342808-yonbowkb 35 7 - - HYPH cord-342808-yonbowkb 35 8 mediated mediate VBN cord-342808-yonbowkb 35 9 mouse mouse NN cord-342808-yonbowkb 35 10 model model NN cord-342808-yonbowkb 35 11 of of IN cord-342808-yonbowkb 35 12 hepatitis hepatitis NNP cord-342808-yonbowkb 35 13 B B NNP cord-342808-yonbowkb 35 14 - - HYPH cord-342808-yonbowkb 35 15 D D NNP cord-342808-yonbowkb 35 16 the the DT cord-342808-yonbowkb 35 17 authors author NNS cord-342808-yonbowkb 35 18 surprisingly surprisingly RB cord-342808-yonbowkb 35 19 found find VBD cord-342808-yonbowkb 35 20 a a DT cord-342808-yonbowkb 35 21 limited limited JJ cord-342808-yonbowkb 35 22 role role NN cord-342808-yonbowkb 35 23 of of IN cord-342808-yonbowkb 35 24 different different JJ cord-342808-yonbowkb 35 25 immune immune JJ cord-342808-yonbowkb 35 26 cell cell NN cord-342808-yonbowkb 35 27 populations population NNS cord-342808-yonbowkb 35 28 ( ( -LRB- cord-342808-yonbowkb 35 29 e.g. e.g. RB cord-342808-yonbowkb 35 30 T T NNP cord-342808-yonbowkb 35 31 cells cell NNS cord-342808-yonbowkb 35 32 or or CC cord-342808-yonbowkb 35 33 natural natural JJ cord-342808-yonbowkb 35 34 killer killer NN cord-342808-yonbowkb 35 35 cells cell NNS cord-342808-yonbowkb 35 36 ) ) -RRB- cord-342808-yonbowkb 35 37 in in IN cord-342808-yonbowkb 35 38 the the DT cord-342808-yonbowkb 35 39 induction induction NN cord-342808-yonbowkb 35 40 of of IN cord-342808-yonbowkb 35 41 liver liver NN cord-342808-yonbowkb 35 42 damage damage NN cord-342808-yonbowkb 35 43 . . . cord-342808-yonbowkb 36 1 By by IN cord-342808-yonbowkb 36 2 contrast contrast NN cord-342808-yonbowkb 36 3 , , , cord-342808-yonbowkb 36 4 interferon interferon NN cord-342808-yonbowkb 36 5 - - HYPH cord-342808-yonbowkb 36 6 and and CC cord-342808-yonbowkb 36 7 tumour tumour NN cord-342808-yonbowkb 36 8 necrosis necrosis NN cord-342808-yonbowkb 36 9 factor factor NN cord-342808-yonbowkb 36 10 alpha alpha NN cord-342808-yonbowkb 36 11 ( ( -LRB- cord-342808-yonbowkb 36 12 TNF TNF NNP cord-342808-yonbowkb 36 13 - - HYPH cord-342808-yonbowkb 36 14 a)-mediated a)-mediated JJ cord-342808-yonbowkb 36 15 pathways pathway NNS cord-342808-yonbowkb 36 16 appeared appear VBD cord-342808-yonbowkb 36 17 to to TO cord-342808-yonbowkb 36 18 be be VB cord-342808-yonbowkb 36 19 of of IN cord-342808-yonbowkb 36 20 crucial crucial JJ cord-342808-yonbowkb 36 21 importance importance NN cord-342808-yonbowkb 36 22 . . . cord-342808-yonbowkb 37 1 Inhibition inhibition NN cord-342808-yonbowkb 37 2 of of IN cord-342808-yonbowkb 37 3 TNF TNF NNP cord-342808-yonbowkb 37 4 - - , cord-342808-yonbowkb 37 5 a a NN cord-342808-yonbowkb 37 6 by by IN cord-342808-yonbowkb 37 7 etanercept etanercept NNP cord-342808-yonbowkb 37 8 ameliorated ameliorate VBN cord-342808-yonbowkb 37 9 hepatitis hepatitis NN cord-342808-yonbowkb 37 10 - - HYPH cord-342808-yonbowkb 37 11 D d JJ cord-342808-yonbowkb 37 12 - - HYPH cord-342808-yonbowkb 37 13 induced induce VBN cord-342808-yonbowkb 37 14 liver liver NN cord-342808-yonbowkb 37 15 damage damage NN cord-342808-yonbowkb 37 16 . . . cord-342808-yonbowkb 38 1 Although although IN cord-342808-yonbowkb 38 2 the the DT cord-342808-yonbowkb 38 3 conclusion conclusion NN cord-342808-yonbowkb 38 4 that that IN cord-342808-yonbowkb 38 5 pharmacological pharmacological JJ cord-342808-yonbowkb 38 6 inhibition inhibition NN cord-342808-yonbowkb 38 7 of of IN cord-342808-yonbowkb 38 8 TNF TNF NNP cord-342808-yonbowkb 38 9 - - : cord-342808-yonbowkb 38 10 a a DT cord-342808-yonbowkb 38 11 represents represent VBZ cord-342808-yonbowkb 38 12 an an DT cord-342808-yonbowkb 38 13 attractive attractive JJ cord-342808-yonbowkb 38 14 strategy strategy NN cord-342808-yonbowkb 38 15 to to TO cord-342808-yonbowkb 38 16 control control VB cord-342808-yonbowkb 38 17 hepatitis hepatitis NN cord-342808-yonbowkb 38 18 - - HYPH cord-342808-yonbowkb 38 19 D D NNP cord-342808-yonbowkb 38 20 - - HYPH cord-342808-yonbowkb 38 21 induced induce VBN cord-342808-yonbowkb 38 22 acute acute JJ cord-342808-yonbowkb 38 23 liver liver NN cord-342808-yonbowkb 38 24 damage damage NN cord-342808-yonbowkb 38 25 is be VBZ cord-342808-yonbowkb 38 26 premature premature JJ cord-342808-yonbowkb 38 27 , , , cord-342808-yonbowkb 38 28 the the DT cord-342808-yonbowkb 38 29 findings finding NNS cord-342808-yonbowkb 38 30 are be VBP cord-342808-yonbowkb 38 31 innovative innovative JJ cord-342808-yonbowkb 38 32 and and CC cord-342808-yonbowkb 38 33 substantially substantially RB cord-342808-yonbowkb 38 34 contribute contribute VB cord-342808-yonbowkb 38 35 to to IN cord-342808-yonbowkb 38 36 our -PRON- PRP$ cord-342808-yonbowkb 38 37 understanding understanding NN cord-342808-yonbowkb 38 38 of of IN cord-342808-yonbowkb 38 39 the the DT cord-342808-yonbowkb 38 40 immunology immunology NN cord-342808-yonbowkb 38 41 of of IN cord-342808-yonbowkb 38 42 hepatitis hepatitis NN cord-342808-yonbowkb 38 43 - - HYPH cord-342808-yonbowkb 38 44 D d JJ cord-342808-yonbowkb 38 45 - - HYPH cord-342808-yonbowkb 38 46 related relate VBN cord-342808-yonbowkb 38 47 disease disease NN cord-342808-yonbowkb 38 48 , , , cord-342808-yonbowkb 38 49 which which WDT cord-342808-yonbowkb 38 50 should should MD cord-342808-yonbowkb 38 51 allow allow VB cord-342808-yonbowkb 38 52 further further JJ cord-342808-yonbowkb 38 53 exploration exploration NN cord-342808-yonbowkb 38 54 of of IN cord-342808-yonbowkb 38 55 the the DT cord-342808-yonbowkb 38 56 manipulation manipulation NN cord-342808-yonbowkb 38 57 of of IN cord-342808-yonbowkb 38 58 these these DT cord-342808-yonbowkb 38 59 pathways pathway NNS cord-342808-yonbowkb 38 60 in in IN cord-342808-yonbowkb 38 61 the the DT cord-342808-yonbowkb 38 62 quest quest NN cord-342808-yonbowkb 38 63 for for IN cord-342808-yonbowkb 38 64 an an DT cord-342808-yonbowkb 38 65 effective effective JJ cord-342808-yonbowkb 38 66 treatment treatment NN cord-342808-yonbowkb 38 67 . . . cord-342808-yonbowkb 39 1 Although although IN cord-342808-yonbowkb 39 2 distinct distinct JJ cord-342808-yonbowkb 39 3 diseases disease NNS cord-342808-yonbowkb 39 4 , , , cord-342808-yonbowkb 39 5 alcoholic alcoholic JJ cord-342808-yonbowkb 39 6 and and CC cord-342808-yonbowkb 39 7 non non JJ cord-342808-yonbowkb 39 8 - - JJ cord-342808-yonbowkb 39 9 alcoholic alcoholic JJ cord-342808-yonbowkb 39 10 fatty fatty JJ cord-342808-yonbowkb 39 11 liver liver NN cord-342808-yonbowkb 39 12 disease disease NN cord-342808-yonbowkb 39 13 ( ( -LRB- cord-342808-yonbowkb 39 14 ALD ALD NNP cord-342808-yonbowkb 39 15 and and CC cord-342808-yonbowkb 39 16 NAFLD NAFLD NNP cord-342808-yonbowkb 39 17 ) ) -RRB- cord-342808-yonbowkb 39 18 share share NN cord-342808-yonbowkb 39 19 multiple multiple JJ cord-342808-yonbowkb 39 20 features feature NNS cord-342808-yonbowkb 39 21 . . . cord-342808-yonbowkb 40 1 Not not RB cord-342808-yonbowkb 40 2 only only RB cord-342808-yonbowkb 40 3 the the DT cord-342808-yonbowkb 40 4 histological histological JJ cord-342808-yonbowkb 40 5 picture picture NN cord-342808-yonbowkb 40 6 , , , cord-342808-yonbowkb 40 7 but but CC cord-342808-yonbowkb 40 8 also also RB cord-342808-yonbowkb 40 9 several several JJ cord-342808-yonbowkb 40 10 pathophysiological pathophysiological JJ cord-342808-yonbowkb 40 11 mechanisms mechanism NNS cord-342808-yonbowkb 40 12 overlap overlap VBP cord-342808-yonbowkb 40 13 , , , cord-342808-yonbowkb 40 14 e.g. e.g. IN cord-342808-yonbowkb 40 15 the the DT cord-342808-yonbowkb 40 16 impact impact NN cord-342808-yonbowkb 40 17 of of IN cord-342808-yonbowkb 40 18 alcohol alcohol NN cord-342808-yonbowkb 40 19 on on IN cord-342808-yonbowkb 40 20 metabolic metabolic JJ cord-342808-yonbowkb 40 21 pathways pathway NNS cord-342808-yonbowkb 40 22 including include VBG cord-342808-yonbowkb 40 23 sterol sterol NN cord-342808-yonbowkb 40 24 regulatory regulatory JJ cord-342808-yonbowkb 40 25 element element NN cord-342808-yonbowkb 40 26 - - HYPH cord-342808-yonbowkb 40 27 binding bind VBG cord-342808-yonbowkb 40 28 protein protein NN cord-342808-yonbowkb 40 29 1c 1c NN cord-342808-yonbowkb 40 30 or or CC cord-342808-yonbowkb 40 31 peroxisome peroxisome NN cord-342808-yonbowkb 40 32 proliferator proliferator NN cord-342808-yonbowkb 40 33 - - HYPH cord-342808-yonbowkb 40 34 activated activate VBN cord-342808-yonbowkb 40 35 receptor receptor NN cord-342808-yonbowkb 40 36 - - , cord-342808-yonbowkb 40 37 a a NN cord-342808-yonbowkb 40 38 that that WDT cord-342808-yonbowkb 40 39 are be VBP cord-342808-yonbowkb 40 40 key key JJ cord-342808-yonbowkb 40 41 metabolic metabolic JJ cord-342808-yonbowkb 40 42 pathways pathway NNS cord-342808-yonbowkb 40 43 in in IN cord-342808-yonbowkb 40 44 the the DT cord-342808-yonbowkb 40 45 pathophysiology pathophysiology NN cord-342808-yonbowkb 40 46 of of IN cord-342808-yonbowkb 40 47 NAFLD NAFLD NNP cord-342808-yonbowkb 40 48 , , , cord-342808-yonbowkb 40 49 6 6 CD cord-342808-yonbowkb 40 50 or or CC cord-342808-yonbowkb 40 51 the the DT cord-342808-yonbowkb 40 52 role role NN cord-342808-yonbowkb 40 53 of of IN cord-342808-yonbowkb 40 54 genetic genetic JJ cord-342808-yonbowkb 40 55 factors factor NNS cord-342808-yonbowkb 40 56 . . . cord-342808-yonbowkb 41 1 Furthermore furthermore RB cord-342808-yonbowkb 41 2 , , , cord-342808-yonbowkb 41 3 in in IN cord-342808-yonbowkb 41 4 many many JJ cord-342808-yonbowkb 41 5 patients patient NNS cord-342808-yonbowkb 41 6 both both CC cord-342808-yonbowkb 41 7 the the DT cord-342808-yonbowkb 41 8 drivers driver NNS cord-342808-yonbowkb 41 9 of of IN cord-342808-yonbowkb 41 10 NAFLD NAFLD NNP cord-342808-yonbowkb 41 11 ( ( -LRB- cord-342808-yonbowkb 41 12 such such JJ cord-342808-yonbowkb 41 13 as as IN cord-342808-yonbowkb 41 14 overweight overweight JJ cord-342808-yonbowkb 41 15 and and CC cord-342808-yonbowkb 41 16 diabetes diabetes NN cord-342808-yonbowkb 41 17 ) ) -RRB- cord-342808-yonbowkb 41 18 and and CC cord-342808-yonbowkb 41 19 the the DT cord-342808-yonbowkb 41 20 use use NN cord-342808-yonbowkb 41 21 of of IN cord-342808-yonbowkb 41 22 alcohol alcohol NN cord-342808-yonbowkb 41 23 are be VBP cord-342808-yonbowkb 41 24 concomitantly concomitantly RB cord-342808-yonbowkb 41 25 present present JJ cord-342808-yonbowkb 41 26 . . . cord-342808-yonbowkb 42 1 This this DT cord-342808-yonbowkb 42 2 can can MD cord-342808-yonbowkb 42 3 impact impact VB cord-342808-yonbowkb 42 4 on on IN cord-342808-yonbowkb 42 5 the the DT cord-342808-yonbowkb 42 6 management management NN cord-342808-yonbowkb 42 7 of of IN cord-342808-yonbowkb 42 8 ALD ALD NNP cord-342808-yonbowkb 42 9 and and CC cord-342808-yonbowkb 42 10 NAFLD NAFLD NNP cord-342808-yonbowkb 42 11 , , , cord-342808-yonbowkb 42 12 elegantly elegantly RB cord-342808-yonbowkb 42 13 summarised summarise VBD cord-342808-yonbowkb 42 14 in in IN cord-342808-yonbowkb 42 15 the the DT cord-342808-yonbowkb 42 16 review review NN cord-342808-yonbowkb 42 17 by by IN cord-342808-yonbowkb 42 18 Louvet Louvet NNP cord-342808-yonbowkb 42 19 et et NNP cord-342808-yonbowkb 42 20 al al NNP cord-342808-yonbowkb 42 21 . . . cord-342808-yonbowkb 43 1 7 7 CD cord-342808-yonbowkb 43 2 One one CD cord-342808-yonbowkb 43 3 of of IN cord-342808-yonbowkb 43 4 the the DT cord-342808-yonbowkb 43 5 aspects aspect NNS cord-342808-yonbowkb 43 6 that that WDT cord-342808-yonbowkb 43 7 is be VBZ cord-342808-yonbowkb 43 8 poorly poorly RB cord-342808-yonbowkb 43 9 touched touch VBN cord-342808-yonbowkb 43 10 upon upon IN cord-342808-yonbowkb 43 11 in in IN cord-342808-yonbowkb 43 12 the the DT cord-342808-yonbowkb 43 13 ( ( -LRB- cord-342808-yonbowkb 43 14 medical medical JJ cord-342808-yonbowkb 43 15 ) ) -RRB- cord-342808-yonbowkb 43 16 management management NN cord-342808-yonbowkb 43 17 of of IN cord-342808-yonbowkb 43 18 patients patient NNS cord-342808-yonbowkb 43 19 , , , cord-342808-yonbowkb 43 20 is be VBZ cord-342808-yonbowkb 43 21 their -PRON- PRP$ cord-342808-yonbowkb 43 22 perceived perceive VBN cord-342808-yonbowkb 43 23 QoL. QoL. NNP cord-342808-yonbowkb 43 24 Several several JJ cord-342808-yonbowkb 43 25 tools tool NNS cord-342808-yonbowkb 43 26 have have VBP cord-342808-yonbowkb 43 27 been be VBN cord-342808-yonbowkb 43 28 developed develop VBN cord-342808-yonbowkb 43 29 over over IN cord-342808-yonbowkb 43 30 time time NN cord-342808-yonbowkb 43 31 to to TO cord-342808-yonbowkb 43 32 capture capture VB cord-342808-yonbowkb 43 33 the the DT cord-342808-yonbowkb 43 34 impact impact NN cord-342808-yonbowkb 43 35 of of IN cord-342808-yonbowkb 43 36 the the DT cord-342808-yonbowkb 43 37 disease disease NN cord-342808-yonbowkb 43 38 on on IN cord-342808-yonbowkb 43 39 this this DT cord-342808-yonbowkb 43 40 important important JJ cord-342808-yonbowkb 43 41 aspect aspect NN cord-342808-yonbowkb 43 42 of of IN cord-342808-yonbowkb 43 43 disease disease NN cord-342808-yonbowkb 43 44 burden burden NN cord-342808-yonbowkb 43 45 , , , cord-342808-yonbowkb 43 46 which which WDT cord-342808-yonbowkb 43 47 is be VBZ cord-342808-yonbowkb 43 48 particularly particularly RB cord-342808-yonbowkb 43 49 challenging challenging JJ cord-342808-yonbowkb 43 50 in in IN cord-342808-yonbowkb 43 51 the the DT cord-342808-yonbowkb 43 52 context context NN cord-342808-yonbowkb 43 53 of of IN cord-342808-yonbowkb 43 54 NAFLD NAFLD NNP cord-342808-yonbowkb 43 55 , , , cord-342808-yonbowkb 43 56 as as IN cord-342808-yonbowkb 43 57 the the DT cord-342808-yonbowkb 43 58 aforementioned aforementioned JJ cord-342808-yonbowkb 43 59 comorbidities comorbiditie NNS cord-342808-yonbowkb 43 60 intrinsically intrinsically RB cord-342808-yonbowkb 43 61 affect affect VBP cord-342808-yonbowkb 43 62 QoL. QoL. NNP cord-342808-yonbowkb 44 1 Sweeney Sweeney NNP cord-342808-yonbowkb 44 2 et et NNP cord-342808-yonbowkb 44 3 al al NNP cord-342808-yonbowkb 44 4 . . . cord-342808-yonbowkb 45 1 extensively extensively RB cord-342808-yonbowkb 45 2 reviewed review VBD cord-342808-yonbowkb 45 3 the the DT cord-342808-yonbowkb 45 4 literature literature NN cord-342808-yonbowkb 45 5 on on IN cord-342808-yonbowkb 45 6 QoL qol NN cord-342808-yonbowkb 45 7 impairment impairment NN cord-342808-yonbowkb 45 8 in in IN cord-342808-yonbowkb 45 9 the the DT cord-342808-yonbowkb 45 10 specific specific JJ cord-342808-yonbowkb 45 11 population population NN cord-342808-yonbowkb 45 12 of of IN cord-342808-yonbowkb 45 13 patients patient NNS cord-342808-yonbowkb 45 14 with with IN cord-342808-yonbowkb 45 15 NAFLD NAFLD NNP cord-342808-yonbowkb 45 16 - - HYPH cord-342808-yonbowkb 45 17 related relate VBN cord-342808-yonbowkb 45 18 compensated compensate VBN cord-342808-yonbowkb 45 19 cirrhosis cirrhosis NN cord-342808-yonbowkb 45 20 , , , cord-342808-yonbowkb 45 21 concluding conclude VBG cord-342808-yonbowkb 45 22 that that IN cord-342808-yonbowkb 45 23 those those DT cord-342808-yonbowkb 45 24 patients patient NNS cord-342808-yonbowkb 45 25 suffer suffer VBP cord-342808-yonbowkb 45 26 significantly significantly RB cord-342808-yonbowkb 45 27 from from IN cord-342808-yonbowkb 45 28 lower low JJR cord-342808-yonbowkb 45 29 QoL qol NN cord-342808-yonbowkb 45 30 and and CC cord-342808-yonbowkb 45 31 poorer poor JJR cord-342808-yonbowkb 45 32 physical physical JJ cord-342808-yonbowkb 45 33 health health NN cord-342808-yonbowkb 45 34 . . . cord-342808-yonbowkb 46 1 8 8 CD cord-342808-yonbowkb 47 1 They -PRON- PRP cord-342808-yonbowkb 47 2 also also RB cord-342808-yonbowkb 47 3 reviewed review VBD cord-342808-yonbowkb 47 4 the the DT cord-342808-yonbowkb 47 5 available available JJ cord-342808-yonbowkb 47 6 patient patient NN cord-342808-yonbowkb 47 7 - - HYPH cord-342808-yonbowkb 47 8 reported report VBN cord-342808-yonbowkb 47 9 outcome outcome NN cord-342808-yonbowkb 47 10 measures measure NNS cord-342808-yonbowkb 47 11 ( ( -LRB- cord-342808-yonbowkb 47 12 PROMs prom NNS cord-342808-yonbowkb 47 13 ) ) -RRB- cord-342808-yonbowkb 47 14 that that WDT cord-342808-yonbowkb 47 15 are be VBP cord-342808-yonbowkb 47 16 increasingly increasingly RB cord-342808-yonbowkb 47 17 important important JJ cord-342808-yonbowkb 47 18 in in IN cord-342808-yonbowkb 47 19 the the DT cord-342808-yonbowkb 47 20 design design NN cord-342808-yonbowkb 47 21 of of IN cord-342808-yonbowkb 47 22 clinical clinical JJ cord-342808-yonbowkb 47 23 trials trial NNS cord-342808-yonbowkb 47 24 and and CC cord-342808-yonbowkb 47 25 patient patient JJ cord-342808-yonbowkb 47 26 management management NN cord-342808-yonbowkb 47 27 policies policy NNS cord-342808-yonbowkb 47 28 . . . cord-342808-yonbowkb 48 1 They -PRON- PRP cord-342808-yonbowkb 48 2 highlight highlight VBP cord-342808-yonbowkb 48 3 the the DT cord-342808-yonbowkb 48 4 current current JJ cord-342808-yonbowkb 48 5 limitations limitation NNS cord-342808-yonbowkb 48 6 of of IN cord-342808-yonbowkb 48 7 the the DT cord-342808-yonbowkb 48 8 PROMs prom NNS cord-342808-yonbowkb 48 9 that that WDT cord-342808-yonbowkb 48 10 have have VBP cord-342808-yonbowkb 48 11 been be VBN cord-342808-yonbowkb 48 12 used use VBN cord-342808-yonbowkb 48 13 so so RB cord-342808-yonbowkb 48 14 far far RB cord-342808-yonbowkb 48 15 and and CC cord-342808-yonbowkb 48 16 conclude conclude VB cord-342808-yonbowkb 48 17 that that IN cord-342808-yonbowkb 48 18 there there EX cord-342808-yonbowkb 48 19 is be VBZ cord-342808-yonbowkb 48 20 a a DT cord-342808-yonbowkb 48 21 need need NN cord-342808-yonbowkb 48 22 for for IN cord-342808-yonbowkb 48 23 a a DT cord-342808-yonbowkb 48 24 standardised standardised JJ cord-342808-yonbowkb 48 25 and and CC cord-342808-yonbowkb 48 26 structured structured JJ cord-342808-yonbowkb 48 27 approach approach NN cord-342808-yonbowkb 48 28 to to IN cord-342808-yonbowkb 48 29 these these DT cord-342808-yonbowkb 48 30 measures measure NNS cord-342808-yonbowkb 48 31 in in IN cord-342808-yonbowkb 48 32 clinical clinical JJ cord-342808-yonbowkb 48 33 trials trial NNS cord-342808-yonbowkb 48 34 of of IN cord-342808-yonbowkb 48 35 patients patient NNS cord-342808-yonbowkb 48 36 with with IN cord-342808-yonbowkb 48 37 NAFLD NAFLD NNP cord-342808-yonbowkb 48 38 - - HYPH cord-342808-yonbowkb 48 39 related relate VBN cord-342808-yonbowkb 48 40 cirrhosis cirrhosis NN cord-342808-yonbowkb 48 41 , , , cord-342808-yonbowkb 48 42 as as RB cord-342808-yonbowkb 48 43 well well RB cord-342808-yonbowkb 48 44 as as IN cord-342808-yonbowkb 48 45 in in IN cord-342808-yonbowkb 48 46 daily daily JJ cord-342808-yonbowkb 48 47 clinical clinical JJ cord-342808-yonbowkb 48 48 practice practice NN cord-342808-yonbowkb 48 49 . . . cord-342808-yonbowkb 49 1 Rare rare JJ cord-342808-yonbowkb 49 2 liver liver NN cord-342808-yonbowkb 49 3 diseases disease NNS cord-342808-yonbowkb 49 4 ask ask VBP cord-342808-yonbowkb 49 5 for for IN cord-342808-yonbowkb 49 6 collaborative collaborative JJ cord-342808-yonbowkb 49 7 efforts effort NNS cord-342808-yonbowkb 49 8 to to TO cord-342808-yonbowkb 49 9 provide provide VB cord-342808-yonbowkb 49 10 high high JJ cord-342808-yonbowkb 49 11 quality quality NN cord-342808-yonbowkb 49 12 data datum NNS cord-342808-yonbowkb 49 13 that that WDT cord-342808-yonbowkb 49 14 can can MD cord-342808-yonbowkb 49 15 solve solve VB cord-342808-yonbowkb 49 16 clinical clinical JJ cord-342808-yonbowkb 49 17 research research NN cord-342808-yonbowkb 49 18 questions question NNS cord-342808-yonbowkb 49 19 . . . cord-342808-yonbowkb 50 1 The the DT cord-342808-yonbowkb 50 2 European European NNP cord-342808-yonbowkb 50 3 Union Union NNP cord-342808-yonbowkb 50 4 has have VBZ cord-342808-yonbowkb 50 5 actively actively RB cord-342808-yonbowkb 50 6 promoted promote VBN cord-342808-yonbowkb 50 7 this this DT cord-342808-yonbowkb 50 8 by by IN cord-342808-yonbowkb 50 9 recognising recognise VBG cord-342808-yonbowkb 50 10 European European NNP cord-342808-yonbowkb 50 11 Reference Reference NNP cord-342808-yonbowkb 50 12 Networks Networks NNP cord-342808-yonbowkb 50 13 ( ( -LRB- cord-342808-yonbowkb 50 14 ERN ERN NNP cord-342808-yonbowkb 50 15 ) ) -RRB- cord-342808-yonbowkb 50 16 for for IN cord-342808-yonbowkb 50 17 rare rare JJ cord-342808-yonbowkb 50 18 diseases disease NNS cord-342808-yonbowkb 50 19 , , , cord-342808-yonbowkb 50 20 including include VBG cord-342808-yonbowkb 50 21 RARE rare JJ cord-342808-yonbowkb 50 22 LIVER liver NN cord-342808-yonbowkb 50 23 for for IN cord-342808-yonbowkb 50 24 rare rare JJ cord-342808-yonbowkb 50 25 liver liver NN cord-342808-yonbowkb 50 26 diseases disease NNS cord-342808-yonbowkb 50 27 . . . cord-342808-yonbowkb 51 1 A a DT cord-342808-yonbowkb 51 2 group group NN cord-342808-yonbowkb 51 3 of of IN cord-342808-yonbowkb 51 4 centres centre NNS cord-342808-yonbowkb 51 5 , , , cord-342808-yonbowkb 51 6 some some DT cord-342808-yonbowkb 51 7 from from IN cord-342808-yonbowkb 51 8 this this DT cord-342808-yonbowkb 51 9 ERN ERN NNP cord-342808-yonbowkb 51 10 , , , cord-342808-yonbowkb 51 11 report report VB cord-342808-yonbowkb 51 12 on on IN cord-342808-yonbowkb 51 13 their -PRON- PRP$ cord-342808-yonbowkb 51 14 pooled pool VBN cord-342808-yonbowkb 51 15 series series NN cord-342808-yonbowkb 51 16 of of IN cord-342808-yonbowkb 51 17 patients patient NNS cord-342808-yonbowkb 51 18 with with IN cord-342808-yonbowkb 51 19 autoimmune autoimmune JJ cord-342808-yonbowkb 51 20 hepatitis hepatitis NN cord-342808-yonbowkb 51 21 with with IN cord-342808-yonbowkb 51 22 normal normal JJ cord-342808-yonbowkb 51 23 IgG igg NN cord-342808-yonbowkb 51 24 levels level NNS cord-342808-yonbowkb 51 25 , , , cord-342808-yonbowkb 51 26 which which WDT cord-342808-yonbowkb 51 27 corresponds correspond VBZ cord-342808-yonbowkb 51 28 to to IN cord-342808-yonbowkb 51 29 10 10 CD cord-342808-yonbowkb 51 30 % % NN cord-342808-yonbowkb 51 31 of of IN cord-342808-yonbowkb 51 32 their -PRON- PRP$ cord-342808-yonbowkb 51 33 patient patient JJ cord-342808-yonbowkb 51 34 population population NN cord-342808-yonbowkb 51 35 . . . cord-342808-yonbowkb 52 1 9 9 CD cord-342808-yonbowkb 53 1 Although although IN cord-342808-yonbowkb 53 2 these these DT cord-342808-yonbowkb 53 3 studies study NNS cord-342808-yonbowkb 53 4 inevitably inevitably RB cord-342808-yonbowkb 53 5 struggle struggle VBP cord-342808-yonbowkb 53 6 with with IN cord-342808-yonbowkb 53 7 their -PRON- PRP$ cord-342808-yonbowkb 53 8 retrospective retrospective JJ cord-342808-yonbowkb 53 9 nature nature NN cord-342808-yonbowkb 53 10 and and CC cord-342808-yonbowkb 53 11 with with IN cord-342808-yonbowkb 53 12 selection selection NN cord-342808-yonbowkb 53 13 bias bias NN cord-342808-yonbowkb 53 14 ( ( -LRB- cord-342808-yonbowkb 53 15 reinforced reinforce VBN cord-342808-yonbowkb 53 16 in in IN cord-342808-yonbowkb 53 17 this this DT cord-342808-yonbowkb 53 18 study study NN cord-342808-yonbowkb 53 19 by by IN cord-342808-yonbowkb 53 20 the the DT cord-342808-yonbowkb 53 21 fact fact NN cord-342808-yonbowkb 53 22 that that IN cord-342808-yonbowkb 53 23 IgG igg NN cord-342808-yonbowkb 53 24 levels level NNS cord-342808-yonbowkb 53 25 are be VBP cord-342808-yonbowkb 53 26 part part NN cord-342808-yonbowkb 53 27 of of IN cord-342808-yonbowkb 53 28 the the DT cord-342808-yonbowkb 53 29 diagnostic diagnostic JJ cord-342808-yonbowkb 53 30 criteria criterion NNS cord-342808-yonbowkb 53 31 for for IN cord-342808-yonbowkb 53 32 autoimmune autoimmune JJ cord-342808-yonbowkb 53 33 hepatitis hepatitis NNP cord-342808-yonbowkb 53 34 ) ) -RRB- cord-342808-yonbowkb 53 35 , , , cord-342808-yonbowkb 53 36 the the DT cord-342808-yonbowkb 53 37 findings finding NNS cord-342808-yonbowkb 53 38 of of IN cord-342808-yonbowkb 53 39 Hartl Hartl NNP cord-342808-yonbowkb 53 40 et et NNP cord-342808-yonbowkb 53 41 al al NNP cord-342808-yonbowkb 53 42 . . . cord-342808-yonbowkb 54 1 are be VBP cord-342808-yonbowkb 54 2 insightful insightful JJ cord-342808-yonbowkb 54 3 and and CC cord-342808-yonbowkb 54 4 substantially substantially RB cord-342808-yonbowkb 54 5 contribute contribute VB cord-342808-yonbowkb 54 6 to to IN cord-342808-yonbowkb 54 7 our -PRON- PRP$ cord-342808-yonbowkb 54 8 understanding understanding NN cord-342808-yonbowkb 54 9 of of IN cord-342808-yonbowkb 54 10 this this DT cord-342808-yonbowkb 54 11 clinical clinical JJ cord-342808-yonbowkb 54 12 entity entity NN cord-342808-yonbowkb 54 13 . . . cord-342808-yonbowkb 55 1 It -PRON- PRP cord-342808-yonbowkb 55 2 appears appear VBZ cord-342808-yonbowkb 55 3 that that IN cord-342808-yonbowkb 55 4 these these DT cord-342808-yonbowkb 55 5 patients patient NNS cord-342808-yonbowkb 55 6 differ differ VBP cord-342808-yonbowkb 55 7 little little JJ cord-342808-yonbowkb 55 8 in in IN cord-342808-yonbowkb 55 9 their -PRON- PRP$ cord-342808-yonbowkb 55 10 characteristics characteristic NNS cord-342808-yonbowkb 55 11 at at IN cord-342808-yonbowkb 55 12 diagnosis diagnosis NN cord-342808-yonbowkb 55 13 compared compare VBN cord-342808-yonbowkb 55 14 to to IN cord-342808-yonbowkb 55 15 patients patient NNS cord-342808-yonbowkb 55 16 with with IN cord-342808-yonbowkb 55 17 a a DT cord-342808-yonbowkb 55 18 typical typical JJ cord-342808-yonbowkb 55 19 elevation elevation NN cord-342808-yonbowkb 55 20 of of IN cord-342808-yonbowkb 55 21 IgG IgG NNP cord-342808-yonbowkb 55 22 , , , cord-342808-yonbowkb 55 23 but but CC cord-342808-yonbowkb 55 24 have have VBP cord-342808-yonbowkb 55 25 a a DT cord-342808-yonbowkb 55 26 higher high JJR cord-342808-yonbowkb 55 27 , , , cord-342808-yonbowkb 55 28 albeit albeit IN cord-342808-yonbowkb 55 29 with with IN cord-342808-yonbowkb 55 30 24 24 CD cord-342808-yonbowkb 55 31 % % NN cord-342808-yonbowkb 55 32 still still RB cord-342808-yonbowkb 55 33 rather rather RB cord-342808-yonbowkb 55 34 low low JJ cord-342808-yonbowkb 55 35 , , , cord-342808-yonbowkb 55 36 chance chance NN cord-342808-yonbowkb 55 37 of of IN cord-342808-yonbowkb 55 38 remaining remain VBG cord-342808-yonbowkb 55 39 in in IN cord-342808-yonbowkb 55 40 stable stable JJ cord-342808-yonbowkb 55 41 remission remission NN cord-342808-yonbowkb 55 42 after after IN cord-342808-yonbowkb 55 43 cessation cessation NN cord-342808-yonbowkb 55 44 of of IN cord-342808-yonbowkb 55 45 all all DT cord-342808-yonbowkb 55 46 treatment treatment NN cord-342808-yonbowkb 55 47 . . . cord-342808-yonbowkb 56 1 The the DT cord-342808-yonbowkb 56 2 issue issue NN cord-342808-yonbowkb 56 3 of of IN cord-342808-yonbowkb 56 4 whether whether IN cord-342808-yonbowkb 56 5 to to TO cord-342808-yonbowkb 56 6 stop stop VB cord-342808-yonbowkb 56 7 any any DT cord-342808-yonbowkb 56 8 immunosuppressive immunosuppressive JJ cord-342808-yonbowkb 56 9 treatment treatment NN cord-342808-yonbowkb 56 10 and and CC cord-342808-yonbowkb 56 11 the the DT cord-342808-yonbowkb 56 12 selection selection NN cord-342808-yonbowkb 56 13 of of IN cord-342808-yonbowkb 56 14 patients patient NNS cord-342808-yonbowkb 56 15 who who WP cord-342808-yonbowkb 56 16 might may MD cord-342808-yonbowkb 56 17 qualify qualify VB cord-342808-yonbowkb 56 18 for for IN cord-342808-yonbowkb 56 19 this this DT cord-342808-yonbowkb 56 20 , , , cord-342808-yonbowkb 56 21 is be VBZ cord-342808-yonbowkb 56 22 still still RB cord-342808-yonbowkb 56 23 ill ill RB cord-342808-yonbowkb 56 24 - - HYPH cord-342808-yonbowkb 56 25 defined define VBN cord-342808-yonbowkb 56 26 and and CC cord-342808-yonbowkb 57 1 hence hence RB cord-342808-yonbowkb 57 2 the the DT cord-342808-yonbowkb 57 3 study study NN cord-342808-yonbowkb 57 4 by by IN cord-342808-yonbowkb 57 5 Hartl Hartl NNP cord-342808-yonbowkb 57 6 et et NNP cord-342808-yonbowkb 57 7 al al NNP cord-342808-yonbowkb 57 8 . . NNP cord-342808-yonbowkb 57 9 is be VBZ cord-342808-yonbowkb 57 10 an an DT cord-342808-yonbowkb 57 11 important important JJ cord-342808-yonbowkb 57 12 contribution contribution NN cord-342808-yonbowkb 57 13 to to TO cord-342808-yonbowkb 57 14 help help VB cord-342808-yonbowkb 57 15 settle settle VB cord-342808-yonbowkb 57 16 this this DT cord-342808-yonbowkb 57 17 clinical clinical JJ cord-342808-yonbowkb 57 18 challenge challenge NN cord-342808-yonbowkb 57 19 . . . cord-342808-yonbowkb 58 1 Wilson Wilson NNP cord-342808-yonbowkb 58 2 's 's POS cord-342808-yonbowkb 58 3 disease disease NN cord-342808-yonbowkb 58 4 is be VBZ cord-342808-yonbowkb 58 5 an an DT cord-342808-yonbowkb 58 6 even even RB cord-342808-yonbowkb 58 7 rarer rare JJR cord-342808-yonbowkb 58 8 condition condition NN cord-342808-yonbowkb 58 9 , , , cord-342808-yonbowkb 58 10 and and CC cord-342808-yonbowkb 58 11 acute acute JJ cord-342808-yonbowkb 58 12 liver liver NN cord-342808-yonbowkb 58 13 failure failure NN cord-342808-yonbowkb 58 14 in in IN cord-342808-yonbowkb 58 15 this this DT cord-342808-yonbowkb 58 16 disease disease NN cord-342808-yonbowkb 58 17 is be VBZ cord-342808-yonbowkb 58 18 usually usually RB cord-342808-yonbowkb 58 19 confined confine VBN cord-342808-yonbowkb 58 20 to to IN cord-342808-yonbowkb 58 21 childhood childhood NN cord-342808-yonbowkb 58 22 or or CC cord-342808-yonbowkb 58 23 young young JJ cord-342808-yonbowkb 58 24 adulthood adulthood NN cord-342808-yonbowkb 58 25 . . . cord-342808-yonbowkb 59 1 In in IN cord-342808-yonbowkb 59 2 this this DT cord-342808-yonbowkb 59 3 issue issue NN cord-342808-yonbowkb 59 4 of of IN cord-342808-yonbowkb 59 5 JHEP JHEP NNP cord-342808-yonbowkb 59 6 Reports Reports NNPS cord-342808-yonbowkb 59 7 , , , cord-342808-yonbowkb 59 8 Shribman Shribman NNP cord-342808-yonbowkb 59 9 et et FW cord-342808-yonbowkb 59 10 al al NNP cord-342808-yonbowkb 59 11 . . . cord-342808-yonbowkb 60 1 not not RB cord-342808-yonbowkb 60 2 only only RB cord-342808-yonbowkb 60 3 report report VB cord-342808-yonbowkb 60 4 on on IN cord-342808-yonbowkb 60 5 a a DT cord-342808-yonbowkb 60 6 very very RB cord-342808-yonbowkb 60 7 rare rare JJ cord-342808-yonbowkb 60 8 case case NN cord-342808-yonbowkb 60 9 of of IN cord-342808-yonbowkb 60 10 acute acute JJ cord-342808-yonbowkb 60 11 liver liver NN cord-342808-yonbowkb 60 12 failure failure NN cord-342808-yonbowkb 60 13 as as IN cord-342808-yonbowkb 60 14 a a DT cord-342808-yonbowkb 60 15 primary primary JJ cord-342808-yonbowkb 60 16 manifestation manifestation NN cord-342808-yonbowkb 60 17 of of IN cord-342808-yonbowkb 60 18 Wilson Wilson NNP cord-342808-yonbowkb 60 19 's 's POS cord-342808-yonbowkb 60 20 disease disease NN cord-342808-yonbowkb 60 21 in in IN cord-342808-yonbowkb 60 22 a a DT cord-342808-yonbowkb 60 23 patient patient NN cord-342808-yonbowkb 60 24 over over IN cord-342808-yonbowkb 60 25 60 60 CD cord-342808-yonbowkb 60 26 years year NNS cord-342808-yonbowkb 60 27 of of IN cord-342808-yonbowkb 60 28 age age NN cord-342808-yonbowkb 60 29 , , , cord-342808-yonbowkb 60 30 but but CC cord-342808-yonbowkb 60 31 also also RB cord-342808-yonbowkb 60 32 report report VB cord-342808-yonbowkb 60 33 the the DT cord-342808-yonbowkb 60 34 experience experience NN cord-342808-yonbowkb 60 35 of of IN cord-342808-yonbowkb 60 36 the the DT cord-342808-yonbowkb 60 37 transplant transplant NN cord-342808-yonbowkb 60 38 community community NN cord-342808-yonbowkb 60 39 in in IN cord-342808-yonbowkb 60 40 the the DT cord-342808-yonbowkb 60 41 United United NNP cord-342808-yonbowkb 60 42 Kingdom Kingdom NNP cord-342808-yonbowkb 60 43 with with IN cord-342808-yonbowkb 60 44 liver liver NN cord-342808-yonbowkb 60 45 transplantation transplantation NN cord-342808-yonbowkb 60 46 in in IN cord-342808-yonbowkb 60 47 this this DT cord-342808-yonbowkb 60 48 specific specific JJ cord-342808-yonbowkb 60 49 setting setting NN cord-342808-yonbowkb 60 50 over over IN cord-342808-yonbowkb 60 51 the the DT cord-342808-yonbowkb 60 52 past past JJ cord-342808-yonbowkb 60 53 2 2 CD cord-342808-yonbowkb 60 54 decades decade NNS cord-342808-yonbowkb 60 55 . . . cord-342808-yonbowkb 61 1 10 10 CD cord-342808-yonbowkb 61 2 Only only RB cord-342808-yonbowkb 61 3 8 8 CD cord-342808-yonbowkb 61 4 such such JJ cord-342808-yonbowkb 61 5 cases case NNS cord-342808-yonbowkb 61 6 of of IN cord-342808-yonbowkb 61 7 acute acute JJ cord-342808-yonbowkb 61 8 liver liver NN cord-342808-yonbowkb 61 9 failure failure NN cord-342808-yonbowkb 61 10 as as IN cord-342808-yonbowkb 61 11 the the DT cord-342808-yonbowkb 61 12 first first JJ cord-342808-yonbowkb 61 13 presentation presentation NN cord-342808-yonbowkb 61 14 of of IN cord-342808-yonbowkb 61 15 Wilson Wilson NNP cord-342808-yonbowkb 61 16 's 's POS cord-342808-yonbowkb 61 17 disease disease NN cord-342808-yonbowkb 61 18 in in IN cord-342808-yonbowkb 61 19 patients patient NNS cord-342808-yonbowkb 61 20 older old JJR cord-342808-yonbowkb 61 21 than than IN cord-342808-yonbowkb 61 22 40 40 CD cord-342808-yonbowkb 61 23 years year NNS cord-342808-yonbowkb 61 24 , , , cord-342808-yonbowkb 61 25 or or CC cord-342808-yonbowkb 61 26 1 1 CD cord-342808-yonbowkb 61 27 in in IN cord-342808-yonbowkb 61 28 1,250 1,250 CD cord-342808-yonbowkb 61 29 listed list VBN cord-342808-yonbowkb 61 30 for for IN cord-342808-yonbowkb 61 31 transplantation transplantation NN cord-342808-yonbowkb 61 32 , , , cord-342808-yonbowkb 61 33 could could MD cord-342808-yonbowkb 61 34 be be VB cord-342808-yonbowkb 61 35 identified identify VBN cord-342808-yonbowkb 61 36 . . . cord-342808-yonbowkb 62 1 Although although IN cord-342808-yonbowkb 62 2 rare rare JJ cord-342808-yonbowkb 62 3 , , , cord-342808-yonbowkb 62 4 this this DT cord-342808-yonbowkb 62 5 implies imply VBZ cord-342808-yonbowkb 62 6 that that IN cord-342808-yonbowkb 62 7 this this DT cord-342808-yonbowkb 62 8 cause cause NN cord-342808-yonbowkb 62 9 of of IN cord-342808-yonbowkb 62 10 acute acute JJ cord-342808-yonbowkb 62 11 liver liver NN cord-342808-yonbowkb 62 12 failure failure NN cord-342808-yonbowkb 62 13 should should MD cord-342808-yonbowkb 62 14 be be VB cord-342808-yonbowkb 62 15 part part NN cord-342808-yonbowkb 62 16 of of IN cord-342808-yonbowkb 62 17 the the DT cord-342808-yonbowkb 62 18 differential differential JJ cord-342808-yonbowkb 62 19 diagnosis diagnosis NN cord-342808-yonbowkb 62 20 of of IN cord-342808-yonbowkb 62 21 acute acute JJ cord-342808-yonbowkb 62 22 liver liver NN cord-342808-yonbowkb 62 23 failure failure NN cord-342808-yonbowkb 62 24 at at IN cord-342808-yonbowkb 62 25 any any DT cord-342808-yonbowkb 62 26 age age NN cord-342808-yonbowkb 62 27 . . . cord-342808-yonbowkb 63 1 Budd Budd NNP cord-342808-yonbowkb 63 2 - - HYPH cord-342808-yonbowkb 63 3 Chiari Chiari NNP cord-342808-yonbowkb 63 4 syndrome syndrome NN cord-342808-yonbowkb 63 5 is be VBZ cord-342808-yonbowkb 63 6 another another DT cord-342808-yonbowkb 63 7 rare rare JJ cord-342808-yonbowkb 63 8 disease disease NN cord-342808-yonbowkb 63 9 with with IN cord-342808-yonbowkb 63 10 multiple multiple JJ cord-342808-yonbowkb 63 11 challenges challenge NNS cord-342808-yonbowkb 63 12 in in IN cord-342808-yonbowkb 63 13 clinical clinical JJ cord-342808-yonbowkb 63 14 management management NN cord-342808-yonbowkb 63 15 . . . cord-342808-yonbowkb 64 1 One one CD cord-342808-yonbowkb 64 2 of of IN cord-342808-yonbowkb 64 3 these these DT cord-342808-yonbowkb 64 4 is be VBZ cord-342808-yonbowkb 64 5 the the DT cord-342808-yonbowkb 64 6 frequent frequent JJ cord-342808-yonbowkb 64 7 occurrence occurrence NN cord-342808-yonbowkb 64 8 of of IN cord-342808-yonbowkb 64 9 benign benign JJ cord-342808-yonbowkb 64 10 regenerative regenerative JJ cord-342808-yonbowkb 64 11 lesions lesion NNS cord-342808-yonbowkb 64 12 that that WDT cord-342808-yonbowkb 64 13 need need VBP cord-342808-yonbowkb 64 14 to to TO cord-342808-yonbowkb 64 15 be be VB cord-342808-yonbowkb 64 16 discriminated discriminate VBN cord-342808-yonbowkb 64 17 from from IN cord-342808-yonbowkb 64 18 malignant malignant JJ cord-342808-yonbowkb 64 19 lesions lesion NNS cord-342808-yonbowkb 64 20 , , , cord-342808-yonbowkb 64 21 especially especially RB cord-342808-yonbowkb 64 22 in in IN cord-342808-yonbowkb 64 23 case case NN cord-342808-yonbowkb 64 24 of of IN cord-342808-yonbowkb 64 25 mild mild JJ cord-342808-yonbowkb 64 26 elevations elevation NNS cord-342808-yonbowkb 64 27 of of IN cord-342808-yonbowkb 64 28 alpha alpha NN cord-342808-yonbowkb 64 29 - - HYPH cord-342808-yonbowkb 64 30 foetoprotein foetoprotein JJ cord-342808-yonbowkb 64 31 that that WDT cord-342808-yonbowkb 64 32 frequently frequently RB cord-342808-yonbowkb 64 33 accompany accompany VBP cord-342808-yonbowkb 64 34 these these DT cord-342808-yonbowkb 64 35 benign benign JJ cord-342808-yonbowkb 64 36 lesions lesion NNS cord-342808-yonbowkb 64 37 . . . cord-342808-yonbowkb 65 1 As as IN cord-342808-yonbowkb 65 2 the the DT cord-342808-yonbowkb 65 3 contrast contrast NN cord-342808-yonbowkb 65 4 dynamics dynamic NNS cord-342808-yonbowkb 65 5 in in IN cord-342808-yonbowkb 65 6 Budd Budd NNP cord-342808-yonbowkb 65 7 - - HYPH cord-342808-yonbowkb 65 8 Chiari Chiari NNP cord-342808-yonbowkb 65 9 syndrome syndrome NN cord-342808-yonbowkb 65 10 are be VBP cord-342808-yonbowkb 65 11 altered alter VBN cord-342808-yonbowkb 65 12 compared compare VBN cord-342808-yonbowkb 65 13 to to IN cord-342808-yonbowkb 65 14 a a DT cord-342808-yonbowkb 65 15 classical classical JJ cord-342808-yonbowkb 65 16 cirrhotic cirrhotic JJ cord-342808-yonbowkb 65 17 condition condition NN cord-342808-yonbowkb 65 18 ( ( -LRB- cord-342808-yonbowkb 65 19 especially especially RB cord-342808-yonbowkb 65 20 impacting impact VBG cord-342808-yonbowkb 65 21 on on IN cord-342808-yonbowkb 65 22 the the DT cord-342808-yonbowkb 65 23 venous venous JJ cord-342808-yonbowkb 65 24 wash wash NN cord-342808-yonbowkb 65 25 - - HYPH cord-342808-yonbowkb 65 26 out out NN cord-342808-yonbowkb 65 27 that that WDT cord-342808-yonbowkb 65 28 is be VBZ cord-342808-yonbowkb 65 29 an an DT cord-342808-yonbowkb 65 30 important important JJ cord-342808-yonbowkb 65 31 criterion criterion NN cord-342808-yonbowkb 65 32 in in IN cord-342808-yonbowkb 65 33 imaging imaging NN cord-342808-yonbowkb 65 34 - - HYPH cord-342808-yonbowkb 65 35 based base VBN cord-342808-yonbowkb 65 36 diagnosis diagnosis NN cord-342808-yonbowkb 65 37 of of IN cord-342808-yonbowkb 65 38 hepatocellular hepatocellular JJ cord-342808-yonbowkb 65 39 carcinoma carcinoma NN cord-342808-yonbowkb 65 40 ) ) -RRB- cord-342808-yonbowkb 65 41 , , , cord-342808-yonbowkb 65 42 and and CC cord-342808-yonbowkb 65 43 as as IN cord-342808-yonbowkb 65 44 the the DT cord-342808-yonbowkb 65 45 regenerative regenerative JJ cord-342808-yonbowkb 65 46 lesions lesion NNS cord-342808-yonbowkb 65 47 in in IN cord-342808-yonbowkb 65 48 Budd Budd NNP cord-342808-yonbowkb 65 49 - - HYPH cord-342808-yonbowkb 65 50 Chiari Chiari NNP cord-342808-yonbowkb 65 51 syndrome syndrome NN cord-342808-yonbowkb 65 52 have have VBP cord-342808-yonbowkb 65 53 features feature NNS cord-342808-yonbowkb 65 54 of of IN cord-342808-yonbowkb 65 55 focal focal JJ cord-342808-yonbowkb 65 56 nodular nodular JJ cord-342808-yonbowkb 65 57 hyperplasia hyperplasia NN cord-342808-yonbowkb 65 58 and and CC cord-342808-yonbowkb 65 59 hence hence RB cord-342808-yonbowkb 65 60 show show VBP cord-342808-yonbowkb 65 61 hyperenhancement hyperenhancement NN cord-342808-yonbowkb 65 62 in in IN cord-342808-yonbowkb 65 63 the the DT cord-342808-yonbowkb 65 64 arterial arterial JJ cord-342808-yonbowkb 65 65 phase phase NN cord-342808-yonbowkb 65 66 of of IN cord-342808-yonbowkb 65 67 contrast contrast NN cord-342808-yonbowkb 65 68 - - HYPH cord-342808-yonbowkb 65 69 enhanced enhance VBN cord-342808-yonbowkb 65 70 imaging imaging NN cord-342808-yonbowkb 65 71 , , , cord-342808-yonbowkb 65 72 the the DT cord-342808-yonbowkb 65 73 classical classical JJ cord-342808-yonbowkb 65 74 imaging imaging NN cord-342808-yonbowkb 65 75 criteria criterion NNS cord-342808-yonbowkb 65 76 do do VBP cord-342808-yonbowkb 65 77 not not RB cord-342808-yonbowkb 65 78 always always RB cord-342808-yonbowkb 65 79 suffice suffice VB cord-342808-yonbowkb 65 80 to to TO cord-342808-yonbowkb 65 81 reliably reliably RB cord-342808-yonbowkb 65 82 rule rule VB cord-342808-yonbowkb 65 83 out out RP cord-342808-yonbowkb 65 84 malignancy malignancy NN cord-342808-yonbowkb 65 85 in in IN cord-342808-yonbowkb 65 86 focal focal JJ cord-342808-yonbowkb 65 87 liver liver NN cord-342808-yonbowkb 65 88 lesions lesion NNS cord-342808-yonbowkb 65 89 of of IN cord-342808-yonbowkb 65 90 patients patient NNS cord-342808-yonbowkb 65 91 with with IN cord-342808-yonbowkb 65 92 Budd Budd NNP cord-342808-yonbowkb 65 93 - - HYPH cord-342808-yonbowkb 65 94 Chiari Chiari NNP cord-342808-yonbowkb 65 95 syndrome syndrome NN cord-342808-yonbowkb 65 96 . . . cord-342808-yonbowkb 66 1 In in IN cord-342808-yonbowkb 66 2 a a DT cord-342808-yonbowkb 66 3 retrospective retrospective JJ cord-342808-yonbowkb 66 4 analysis analysis NN cord-342808-yonbowkb 66 5 of of IN cord-342808-yonbowkb 66 6 26 26 CD cord-342808-yonbowkb 66 7 patients patient NNS cord-342808-yonbowkb 66 8 with with IN cord-342808-yonbowkb 66 9 suspected suspect VBN cord-342808-yonbowkb 66 10 liver liver NN cord-342808-yonbowkb 66 11 lesions lesion NNS cord-342808-yonbowkb 66 12 ( ( -LRB- cord-342808-yonbowkb 66 13 a a DT cord-342808-yonbowkb 66 14 large large JJ cord-342808-yonbowkb 66 15 single single JJ cord-342808-yonbowkb 66 16 centre centre NN cord-342808-yonbowkb 66 17 series series NN cord-342808-yonbowkb 66 18 for for IN cord-342808-yonbowkb 66 19 this this DT cord-342808-yonbowkb 66 20 condition condition NN cord-342808-yonbowkb 66 21 ) ) -RRB- cord-342808-yonbowkb 66 22 , , , cord-342808-yonbowkb 66 23 Van Van NNP cord-342808-yonbowkb 66 24 Wettere Wettere NNP cord-342808-yonbowkb 66 25 et et FW cord-342808-yonbowkb 66 26 al al NNP cord-342808-yonbowkb 66 27 . . . cord-342808-yonbowkb 67 1 report report VB cord-342808-yonbowkb 67 2 on on IN cord-342808-yonbowkb 67 3 the the DT cord-342808-yonbowkb 67 4 accuracy accuracy NN cord-342808-yonbowkb 67 5 of of IN cord-342808-yonbowkb 67 6 MRI MRI NNP cord-342808-yonbowkb 67 7 with with IN cord-342808-yonbowkb 67 8 hepatobiliary hepatobiliary JJ cord-342808-yonbowkb 67 9 excretion excretion NN cord-342808-yonbowkb 67 10 contrast contrast NN cord-342808-yonbowkb 67 11 agent agent NN cord-342808-yonbowkb 67 12 in in IN cord-342808-yonbowkb 67 13 differentiating differentiate VBG cord-342808-yonbowkb 67 14 hepatocellular hepatocellular JJ cord-342808-yonbowkb 67 15 carcinoma carcinoma NN cord-342808-yonbowkb 67 16 lesions lesion NNS cord-342808-yonbowkb 67 17 , , , cord-342808-yonbowkb 67 18 which which WDT cord-342808-yonbowkb 67 19 were be VBD cord-342808-yonbowkb 67 20 all all DT cord-342808-yonbowkb 67 21 homogenously homogenously RB cord-342808-yonbowkb 67 22 hypointense hypointense NN cord-342808-yonbowkb 67 23 in in IN cord-342808-yonbowkb 67 24 the the DT cord-342808-yonbowkb 67 25 hepatobiliary hepatobiliary JJ cord-342808-yonbowkb 67 26 excretion excretion NN cord-342808-yonbowkb 67 27 phase phase NN cord-342808-yonbowkb 67 28 , , , cord-342808-yonbowkb 67 29 from from IN cord-342808-yonbowkb 67 30 the the DT cord-342808-yonbowkb 67 31 benign benign JJ cord-342808-yonbowkb 67 32 lesions lesion NNS cord-342808-yonbowkb 67 33 , , , cord-342808-yonbowkb 67 34 which which WDT cord-342808-yonbowkb 67 35 were be VBD cord-342808-yonbowkb 67 36 almost almost RB cord-342808-yonbowkb 67 37 all all DT cord-342808-yonbowkb 67 38 hyperintense hyperintense NN cord-342808-yonbowkb 67 39 , , , cord-342808-yonbowkb 67 40 at at IN cord-342808-yonbowkb 67 41 least least JJS cord-342808-yonbowkb 67 42 in in IN cord-342808-yonbowkb 67 43 the the DT cord-342808-yonbowkb 67 44 periphery periphery NN cord-342808-yonbowkb 67 45 of of IN cord-342808-yonbowkb 67 46 the the DT cord-342808-yonbowkb 67 47 lesion lesion NN cord-342808-yonbowkb 67 48 , , , cord-342808-yonbowkb 67 49 or or CC cord-342808-yonbowkb 67 50 also also RB cord-342808-yonbowkb 67 51 homogenously homogenously RB cord-342808-yonbowkb 67 52 . . . cord-342808-yonbowkb 68 1 11 11 CD cord-342808-yonbowkb 68 2 Diagnostic diagnostic JJ cord-342808-yonbowkb 68 3 accuracy accuracy NN cord-342808-yonbowkb 68 4 was be VBD cord-342808-yonbowkb 68 5 very very RB cord-342808-yonbowkb 68 6 high high JJ cord-342808-yonbowkb 68 7 , , , cord-342808-yonbowkb 68 8 especially especially RB cord-342808-yonbowkb 68 9 in in IN cord-342808-yonbowkb 68 10 combination combination NN cord-342808-yonbowkb 68 11 with with IN cord-342808-yonbowkb 68 12 an an DT cord-342808-yonbowkb 68 13 alphafoetoprotein alphafoetoprotein JJ cord-342808-yonbowkb 68 14 level level NN cord-342808-yonbowkb 68 15 > > XX cord-342808-yonbowkb 68 16 15 15 CD cord-342808-yonbowkb 68 17 ng ng NN cord-342808-yonbowkb 68 18 / / SYM cord-342808-yonbowkb 68 19 ml ml NN cord-342808-yonbowkb 68 20 . . . cord-342808-yonbowkb 69 1 This this DT cord-342808-yonbowkb 69 2 important important JJ cord-342808-yonbowkb 69 3 observation observation NN cord-342808-yonbowkb 69 4 is be VBZ cord-342808-yonbowkb 69 5 of of IN cord-342808-yonbowkb 69 6 great great JJ cord-342808-yonbowkb 69 7 relevance relevance NN cord-342808-yonbowkb 69 8 in in IN cord-342808-yonbowkb 69 9 the the DT cord-342808-yonbowkb 69 10 management management NN cord-342808-yonbowkb 69 11 of of IN cord-342808-yonbowkb 69 12 Budd Budd NNP cord-342808-yonbowkb 69 13 - - HYPH cord-342808-yonbowkb 69 14 Chiari Chiari NNP cord-342808-yonbowkb 69 15 syndrome syndrome NN cord-342808-yonbowkb 69 16 . . . cord-342808-yonbowkb 70 1 From from IN cord-342808-yonbowkb 70 2 the the DT cord-342808-yonbowkb 70 3 same same JJ cord-342808-yonbowkb 70 4 group group NN cord-342808-yonbowkb 70 5 , , , cord-342808-yonbowkb 70 6 the the DT cord-342808-yonbowkb 70 7 current current JJ cord-342808-yonbowkb 70 8 issue issue NN cord-342808-yonbowkb 70 9 of of IN cord-342808-yonbowkb 70 10 JHEP JHEP NNP cord-342808-yonbowkb 70 11 Reports Reports NNPS cord-342808-yonbowkb 70 12 offers offer VBZ cord-342808-yonbowkb 70 13 a a DT cord-342808-yonbowkb 70 14 comprehensive comprehensive JJ cord-342808-yonbowkb 70 15 state state NN cord-342808-yonbowkb 70 16 - - HYPH cord-342808-yonbowkb 70 17 of of IN cord-342808-yonbowkb 70 18 - - HYPH cord-342808-yonbowkb 70 19 the the DT cord-342808-yonbowkb 70 20 - - HYPH cord-342808-yonbowkb 70 21 art art NN cord-342808-yonbowkb 70 22 overview overview NN cord-342808-yonbowkb 70 23 of of IN cord-342808-yonbowkb 70 24 the the DT cord-342808-yonbowkb 70 25 role role NN cord-342808-yonbowkb 70 26 of of IN cord-342808-yonbowkb 70 27 imaging image VBG cord-342808-yonbowkb 70 28 in in IN cord-342808-yonbowkb 70 29 the the DT cord-342808-yonbowkb 70 30 diagnosis diagnosis NN cord-342808-yonbowkb 70 31 of of IN cord-342808-yonbowkb 70 32 liver liver NN cord-342808-yonbowkb 70 33 tumours tumour NNS cord-342808-yonbowkb 70 34 , , , cord-342808-yonbowkb 70 35 focusing focus VBG cord-342808-yonbowkb 70 36 mainly mainly RB cord-342808-yonbowkb 70 37 but but CC cord-342808-yonbowkb 70 38 not not RB cord-342808-yonbowkb 70 39 exclusively exclusively RB cord-342808-yonbowkb 70 40 , , , cord-342808-yonbowkb 70 41 on on IN cord-342808-yonbowkb 70 42 hepatocellular hepatocellular JJ cord-342808-yonbowkb 70 43 carcinoma carcinoma NN cord-342808-yonbowkb 70 44 . . . cord-342808-yonbowkb 71 1 Besides besides IN cord-342808-yonbowkb 71 2 a a DT cord-342808-yonbowkb 71 3 detailed detailed JJ cord-342808-yonbowkb 71 4 and and CC cord-342808-yonbowkb 71 5 critical critical JJ cord-342808-yonbowkb 71 6 appraisal appraisal NN cord-342808-yonbowkb 71 7 of of IN cord-342808-yonbowkb 71 8 what what WP cord-342808-yonbowkb 71 9 has have VBZ cord-342808-yonbowkb 71 10 become become VBN cord-342808-yonbowkb 71 11 standard standard NN cord-342808-yonbowkb 71 12 of of IN cord-342808-yonbowkb 71 13 care care NN cord-342808-yonbowkb 71 14 , , , cord-342808-yonbowkb 71 15 Gregory Gregory NNP cord-342808-yonbowkb 71 16 et et NNP cord-342808-yonbowkb 71 17 al al NNP cord-342808-yonbowkb 71 18 . . NNP cord-342808-yonbowkb 71 19 shed shed VBD cord-342808-yonbowkb 71 20 light light NN cord-342808-yonbowkb 71 21 on on IN cord-342808-yonbowkb 71 22 the the DT cord-342808-yonbowkb 71 23 future future JJ cord-342808-yonbowkb 71 24 role role NN cord-342808-yonbowkb 71 25 of of IN cord-342808-yonbowkb 71 26 imaging image VBG cord-342808-yonbowkb 71 27 in in IN cord-342808-yonbowkb 71 28 the the DT cord-342808-yonbowkb 71 29 clinical clinical JJ cord-342808-yonbowkb 71 30 management management NN cord-342808-yonbowkb 71 31 of of IN cord-342808-yonbowkb 71 32 patients patient NNS cord-342808-yonbowkb 71 33 with with IN cord-342808-yonbowkb 71 34 a a DT cord-342808-yonbowkb 71 35 large large JJ cord-342808-yonbowkb 71 36 variety variety NN cord-342808-yonbowkb 71 37 of of IN cord-342808-yonbowkb 71 38 liver liver NN cord-342808-yonbowkb 71 39 tumours tumour NNS cord-342808-yonbowkb 71 40 . . . cord-342808-yonbowkb 72 1 12 12 CD cord-342808-yonbowkb 73 1 Of of IN cord-342808-yonbowkb 73 2 particular particular JJ cord-342808-yonbowkb 73 3 interest interest NN cord-342808-yonbowkb 73 4 is be VBZ cord-342808-yonbowkb 73 5 the the DT cord-342808-yonbowkb 73 6 assessment assessment NN cord-342808-yonbowkb 73 7 of of IN cord-342808-yonbowkb 73 8 tumour tumour NN cord-342808-yonbowkb 73 9 response response NN cord-342808-yonbowkb 73 10 to to IN cord-342808-yonbowkb 73 11 various various JJ cord-342808-yonbowkb 73 12 therapies therapy NNS cord-342808-yonbowkb 73 13 . . . cord-342808-yonbowkb 74 1 This this DT cord-342808-yonbowkb 74 2 goes go VBZ cord-342808-yonbowkb 74 3 beyond beyond IN cord-342808-yonbowkb 74 4 the the DT cord-342808-yonbowkb 74 5 assessment assessment NN cord-342808-yonbowkb 74 6 of of IN cord-342808-yonbowkb 74 7 viable viable JJ cord-342808-yonbowkb 74 8 tumour tumour NN cord-342808-yonbowkb 74 9 tissue tissue NN cord-342808-yonbowkb 74 10 , , , cord-342808-yonbowkb 74 11 for for IN cord-342808-yonbowkb 74 12 some some DT cord-342808-yonbowkb 74 13 years year NNS cord-342808-yonbowkb 74 14 the the DT cord-342808-yonbowkb 74 15 cornerstone cornerstone NN cord-342808-yonbowkb 74 16 of of IN cord-342808-yonbowkb 74 17 treatment treatment NN cord-342808-yonbowkb 74 18 response response NN cord-342808-yonbowkb 74 19 assessment assessment NN cord-342808-yonbowkb 74 20 in in IN cord-342808-yonbowkb 74 21 hepatocellular hepatocellular JJ cord-342808-yonbowkb 74 22 carcinoma carcinoma NN cord-342808-yonbowkb 74 23 . . . cord-342808-yonbowkb 75 1 The the DT cord-342808-yonbowkb 75 2 response response NN cord-342808-yonbowkb 75 3 to to IN cord-342808-yonbowkb 75 4 immunotherapy immunotherapy NN cord-342808-yonbowkb 75 5 is be VBZ cord-342808-yonbowkb 75 6 particularly particularly RB cord-342808-yonbowkb 75 7 challenging challenging JJ cord-342808-yonbowkb 75 8 due due IN cord-342808-yonbowkb 75 9 to to IN cord-342808-yonbowkb 75 10 specific specific JJ cord-342808-yonbowkb 75 11 radiological radiological JJ cord-342808-yonbowkb 75 12 images image NNS cord-342808-yonbowkb 75 13 that that WDT cord-342808-yonbowkb 75 14 appear appear VBP cord-342808-yonbowkb 75 15 in in IN cord-342808-yonbowkb 75 16 line line NN cord-342808-yonbowkb 75 17 with with IN cord-342808-yonbowkb 75 18 dynamics dynamic NNS cord-342808-yonbowkb 75 19 of of IN cord-342808-yonbowkb 75 20 treatment treatment NN cord-342808-yonbowkb 75 21 - - HYPH cord-342808-yonbowkb 75 22 induced induce VBN cord-342808-yonbowkb 75 23 alterations alteration NNS cord-342808-yonbowkb 75 24 . . . cord-342808-yonbowkb 76 1 3D 3D NNP cord-342808-yonbowkb 76 2 volumetry volumetry NNP cord-342808-yonbowkb 76 3 and and CC cord-342808-yonbowkb 76 4 radiomics radiomics NNP cord-342808-yonbowkb 76 5 offer offer VBP cord-342808-yonbowkb 76 6 new new JJ cord-342808-yonbowkb 76 7 perspectives perspective NNS cord-342808-yonbowkb 76 8 , , , cord-342808-yonbowkb 76 9 the the DT cord-342808-yonbowkb 76 10 latter latter JJ cord-342808-yonbowkb 76 11 working work VBG cord-342808-yonbowkb 76 12 on on IN cord-342808-yonbowkb 76 13 voxel voxel NN cord-342808-yonbowkb 76 14 level level NN cord-342808-yonbowkb 76 15 , , , cord-342808-yonbowkb 76 16 mathematically mathematically RB cord-342808-yonbowkb 76 17 analysing analyse VBG cord-342808-yonbowkb 76 18 and and CC cord-342808-yonbowkb 76 19 manipulating manipulate VBG cord-342808-yonbowkb 76 20 their -PRON- PRP$ cord-342808-yonbowkb 76 21 binary binary JJ cord-342808-yonbowkb 76 22 signatures signature NNS cord-342808-yonbowkb 76 23 in in IN cord-342808-yonbowkb 76 24 complex complex JJ cord-342808-yonbowkb 76 25 models model NNS cord-342808-yonbowkb 76 26 , , , cord-342808-yonbowkb 76 27 allowing allow VBG cord-342808-yonbowkb 76 28 to to TO cord-342808-yonbowkb 76 29 go go VB cord-342808-yonbowkb 76 30 beyond beyond IN cord-342808-yonbowkb 76 31 size size NN cord-342808-yonbowkb 76 32 or or CC cord-342808-yonbowkb 76 33 human human JJ cord-342808-yonbowkb 76 34 - - HYPH cord-342808-yonbowkb 76 35 eye eye NN cord-342808-yonbowkb 76 36 based base VBN cord-342808-yonbowkb 76 37 semantic semantic JJ cord-342808-yonbowkb 76 38 descriptors descriptor NNS cord-342808-yonbowkb 76 39 . . . cord-342808-yonbowkb 77 1 Also also RB cord-342808-yonbowkb 77 2 , , , cord-342808-yonbowkb 77 3 quantitative quantitative JJ cord-342808-yonbowkb 77 4 and and CC cord-342808-yonbowkb 77 5 functional functional JJ cord-342808-yonbowkb 77 6 imaging imaging NN cord-342808-yonbowkb 77 7 provide provide VBP cord-342808-yonbowkb 77 8 insight insight NN cord-342808-yonbowkb 77 9 into into IN cord-342808-yonbowkb 77 10 microscopic microscopic JJ cord-342808-yonbowkb 77 11 tumour tumour NN cord-342808-yonbowkb 77 12 changes change NNS cord-342808-yonbowkb 77 13 that that WDT cord-342808-yonbowkb 77 14 may may MD cord-342808-yonbowkb 77 15 be be VB cord-342808-yonbowkb 77 16 used use VBN cord-342808-yonbowkb 77 17 as as IN cord-342808-yonbowkb 77 18 early early JJ cord-342808-yonbowkb 77 19 predictors predictor NNS cord-342808-yonbowkb 77 20 of of IN cord-342808-yonbowkb 77 21 response response NN cord-342808-yonbowkb 77 22 . . . cord-342808-yonbowkb 78 1 This this DT cord-342808-yonbowkb 78 2 elegant elegant JJ cord-342808-yonbowkb 78 3 review review NN cord-342808-yonbowkb 78 4 will will MD cord-342808-yonbowkb 78 5 guide guide VB cord-342808-yonbowkb 78 6 clinicians clinician NNS cord-342808-yonbowkb 78 7 through through IN cord-342808-yonbowkb 78 8 the the DT cord-342808-yonbowkb 78 9 fascinating fascinating JJ cord-342808-yonbowkb 78 10 innovations innovation NNS cord-342808-yonbowkb 78 11 that that WDT cord-342808-yonbowkb 78 12 imaging imaging NN cord-342808-yonbowkb 78 13 is be VBZ cord-342808-yonbowkb 78 14 offering offer VBG cord-342808-yonbowkb 78 15 in in IN cord-342808-yonbowkb 78 16 diagnosing diagnose VBG cord-342808-yonbowkb 78 17 these these DT cord-342808-yonbowkb 78 18 various various JJ cord-342808-yonbowkb 78 19 liver liver NN cord-342808-yonbowkb 78 20 tumours tumour NNS cord-342808-yonbowkb 78 21 and and CC cord-342808-yonbowkb 78 22 in in IN cord-342808-yonbowkb 78 23 assessing assess VBG cord-342808-yonbowkb 78 24 treatment treatment NN cord-342808-yonbowkb 78 25 responses response NNS cord-342808-yonbowkb 78 26 ( ( -LRB- cord-342808-yonbowkb 78 27 to to IN cord-342808-yonbowkb 78 28 therapies therapy NNS cord-342808-yonbowkb 78 29 with with IN cord-342808-yonbowkb 78 30 different different JJ cord-342808-yonbowkb 78 31 modes mode NNS cord-342808-yonbowkb 78 32 of of IN cord-342808-yonbowkb 78 33 action action NN cord-342808-yonbowkb 78 34 , , , cord-342808-yonbowkb 78 35 which which WDT cord-342808-yonbowkb 78 36 require require VBP cord-342808-yonbowkb 78 37 different different JJ cord-342808-yonbowkb 78 38 corresponding correspond VBG cord-342808-yonbowkb 78 39 imaging imaging NN cord-342808-yonbowkb 78 40 modalities modality NNS cord-342808-yonbowkb 78 41 ) ) -RRB- cord-342808-yonbowkb 78 42 . . . cord-342808-yonbowkb 79 1 We -PRON- PRP cord-342808-yonbowkb 79 2 hope hope VBP cord-342808-yonbowkb 79 3 you -PRON- PRP cord-342808-yonbowkb 79 4 enjoy enjoy VBP cord-342808-yonbowkb 79 5 the the DT cord-342808-yonbowkb 79 6 issue issue NN cord-342808-yonbowkb 79 7 ! ! . cord-342808-yonbowkb 80 1 Care care NN cord-342808-yonbowkb 80 2 of of IN cord-342808-yonbowkb 80 3 patients patient NNS cord-342808-yonbowkb 80 4 with with IN cord-342808-yonbowkb 80 5 liver liver NN cord-342808-yonbowkb 80 6 disease disease NN cord-342808-yonbowkb 80 7 during during IN cord-342808-yonbowkb 80 8 the the DT cord-342808-yonbowkb 80 9 COVID-19 COVID-19 NNP cord-342808-yonbowkb 80 10 pandemic pandemic NN cord-342808-yonbowkb 80 11 : : : cord-342808-yonbowkb 81 1 EASL EASL NNP cord-342808-yonbowkb 81 2 - - HYPH cord-342808-yonbowkb 81 3 ESCMID ESCMID NNP cord-342808-yonbowkb 81 4 position position NN cord-342808-yonbowkb 81 5 paper paper NN cord-342808-yonbowkb 81 6 Rebound rebound NN cord-342808-yonbowkb 81 7 of of IN cord-342808-yonbowkb 81 8 HBV HBV NNP cord-342808-yonbowkb 81 9 DNA DNA NNP cord-342808-yonbowkb 81 10 after after IN cord-342808-yonbowkb 81 11 cessation cessation NN cord-342808-yonbowkb 81 12 of of IN cord-342808-yonbowkb 81 13 nucleos nucleos NNP cord-342808-yonbowkb 81 14 / / SYM cord-342808-yonbowkb 81 15 tide tide NN cord-342808-yonbowkb 81 16 analogues analogue NNS cord-342808-yonbowkb 81 17 in in IN cord-342808-yonbowkb 81 18 chronic chronic JJ cord-342808-yonbowkb 81 19 hepatitis hepatitis NN cord-342808-yonbowkb 81 20 B B NNP cord-342808-yonbowkb 81 21 patients patient NNS cord-342808-yonbowkb 81 22 with with IN cord-342808-yonbowkb 81 23 undetectable undetectable JJ cord-342808-yonbowkb 81 24 covalently covalently RB cord-342808-yonbowkb 81 25 closed closed JJ cord-342808-yonbowkb 81 26 circular circular JJ cord-342808-yonbowkb 81 27 DNA dna NN cord-342808-yonbowkb 81 28 Stopping stop VBG cord-342808-yonbowkb 81 29 nucleos(t)ide nucleos(t)ide JJ cord-342808-yonbowkb 81 30 analogue analogue JJ cord-342808-yonbowkb 81 31 treatment treatment NN cord-342808-yonbowkb 81 32 in in IN cord-342808-yonbowkb 81 33 Caucasian caucasian JJ cord-342808-yonbowkb 81 34 hepatitis hepatitis NN cord-342808-yonbowkb 81 35 B B NNP cord-342808-yonbowkb 81 36 patients patient NNS cord-342808-yonbowkb 81 37 after after IN cord-342808-yonbowkb 81 38 HBeAg hbeag CD cord-342808-yonbowkb 81 39 seroconversion seroconversion NN cord-342808-yonbowkb 81 40 is be VBZ cord-342808-yonbowkb 81 41 associated associate VBN cord-342808-yonbowkb 81 42 with with IN cord-342808-yonbowkb 81 43 high high JJ cord-342808-yonbowkb 81 44 relapse relapse NN cord-342808-yonbowkb 81 45 rates rate NNS cord-342808-yonbowkb 81 46 and and CC cord-342808-yonbowkb 81 47 fatal fatal JJ cord-342808-yonbowkb 81 48 outcomes outcome NNS cord-342808-yonbowkb 81 49 Treating treat VBG cord-342808-yonbowkb 81 50 chronic chronic JJ cord-342808-yonbowkb 81 51 hepatitis hepatitis NN cord-342808-yonbowkb 81 52 delta delta NN cord-342808-yonbowkb 81 53 : : : cord-342808-yonbowkb 82 1 the the DT cord-342808-yonbowkb 82 2 need need NN cord-342808-yonbowkb 82 3 for for IN cord-342808-yonbowkb 82 4 surrogate surrogate JJ cord-342808-yonbowkb 82 5 markers marker NNS cord-342808-yonbowkb 82 6 of of IN cord-342808-yonbowkb 82 7 treatment treatment NN cord-342808-yonbowkb 82 8 efficacy efficacy NN cord-342808-yonbowkb 82 9 TNF tnf NN cord-342808-yonbowkb 82 10 - - HYPH cord-342808-yonbowkb 82 11 alpha alpha NN cord-342808-yonbowkb 82 12 inhibition inhibition NN cord-342808-yonbowkb 82 13 ameliorates ameliorate VBZ cord-342808-yonbowkb 82 14 HDV HDV NNP cord-342808-yonbowkb 82 15 - - HYPH cord-342808-yonbowkb 82 16 induced induce VBN cord-342808-yonbowkb 82 17 liver liver NN cord-342808-yonbowkb 82 18 damage damage NN cord-342808-yonbowkb 82 19 in in IN cord-342808-yonbowkb 82 20 a a DT cord-342808-yonbowkb 82 21 mouse mouse NN cord-342808-yonbowkb 82 22 model model NN cord-342808-yonbowkb 82 23 of of IN cord-342808-yonbowkb 82 24 acute acute JJ cord-342808-yonbowkb 82 25 severe severe JJ cord-342808-yonbowkb 82 26 infection infection NN cord-342808-yonbowkb 82 27 PPARa PPARa NNS cord-342808-yonbowkb 82 28 gene gene NN cord-342808-yonbowkb 82 29 expression expression NN cord-342808-yonbowkb 82 30 correlates correlate VBZ cord-342808-yonbowkb 82 31 with with IN cord-342808-yonbowkb 82 32 severity severity NN cord-342808-yonbowkb 82 33 and and CC cord-342808-yonbowkb 82 34 histological histological JJ cord-342808-yonbowkb 82 35 treatment treatment NN cord-342808-yonbowkb 82 36 response response NN cord-342808-yonbowkb 82 37 in in IN cord-342808-yonbowkb 82 38 patients patient NNS cord-342808-yonbowkb 82 39 with with IN cord-342808-yonbowkb 82 40 non non JJ cord-342808-yonbowkb 82 41 - - JJ cord-342808-yonbowkb 82 42 alcoholic alcoholic JJ cord-342808-yonbowkb 82 43 steatohepatitis steatohepatitis NN cord-342808-yonbowkb 82 44 Combined combine VBN cord-342808-yonbowkb 82 45 alcoholic alcoholic JJ cord-342808-yonbowkb 82 46 and and CC cord-342808-yonbowkb 82 47 non non JJ cord-342808-yonbowkb 82 48 - - JJ cord-342808-yonbowkb 82 49 alcoholic alcoholic JJ cord-342808-yonbowkb 82 50 steatohepatitis steatohepatitis NNP cord-342808-yonbowkb 82 51 Health Health NNP cord-342808-yonbowkb 82 52 - - HYPH cord-342808-yonbowkb 82 53 related relate VBN cord-342808-yonbowkb 82 54 quality quality NN cord-342808-yonbowkb 82 55 of of IN cord-342808-yonbowkb 82 56 life life NN cord-342808-yonbowkb 82 57 and and CC cord-342808-yonbowkb 82 58 patient patient NN cord-342808-yonbowkb 82 59 - - HYPH cord-342808-yonbowkb 82 60 reported report VBN cord-342808-yonbowkb 82 61 outcome outcome NN cord-342808-yonbowkb 82 62 measures measure NNS cord-342808-yonbowkb 82 63 in in IN cord-342808-yonbowkb 82 64 NASH NASH NNP cord-342808-yonbowkb 82 65 - - HYPH cord-342808-yonbowkb 82 66 related relate VBN cord-342808-yonbowkb 82 67 cirrhosis cirrhosis NN cord-342808-yonbowkb 82 68 Features feature NNS cord-342808-yonbowkb 82 69 and and CC cord-342808-yonbowkb 82 70 outcome outcome NN cord-342808-yonbowkb 82 71 of of IN cord-342808-yonbowkb 82 72 AIH AIH NNP cord-342808-yonbowkb 82 73 patients patient NNS cord-342808-yonbowkb 82 74 without without IN cord-342808-yonbowkb 82 75 elevation elevation NN cord-342808-yonbowkb 82 76 of of IN cord-342808-yonbowkb 82 77 IgG IgG NNP cord-342808-yonbowkb 82 78 Liver Liver NNP cord-342808-yonbowkb 82 79 transplantation transplantation NN cord-342808-yonbowkb 82 80 for for IN cord-342808-yonbowkb 82 81 late late JJ cord-342808-yonbowkb 82 82 - - HYPH cord-342808-yonbowkb 82 83 onset onset NN cord-342808-yonbowkb 82 84 presentations presentation NNS cord-342808-yonbowkb 82 85 of of IN cord-342808-yonbowkb 82 86 acute acute JJ cord-342808-yonbowkb 82 87 liver liver NN cord-342808-yonbowkb 82 88 failure failure NN cord-342808-yonbowkb 82 89 in in IN cord-342808-yonbowkb 82 90 Wilson Wilson NNP cord-342808-yonbowkb 82 91 's 's POS cord-342808-yonbowkb 82 92 disease disease NN cord-342808-yonbowkb 82 93 : : : cord-342808-yonbowkb 82 94 the the DT cord-342808-yonbowkb 82 95 UK UK NNP cord-342808-yonbowkb 82 96 experience experience NN cord-342808-yonbowkb 82 97 over over IN cord-342808-yonbowkb 82 98 2 2 CD cord-342808-yonbowkb 82 99 decades decade NNS cord-342808-yonbowkb 82 100 Hepatobiliary Hepatobiliary NNP cord-342808-yonbowkb 82 101 MR MR NNP cord-342808-yonbowkb 82 102 contrast contrast NN cord-342808-yonbowkb 82 103 agents agent NNS cord-342808-yonbowkb 82 104 are be VBP cord-342808-yonbowkb 82 105 useful useful JJ cord-342808-yonbowkb 82 106 to to TO cord-342808-yonbowkb 82 107 diagnose diagnose VB cord-342808-yonbowkb 82 108 hepatocellular hepatocellular JJ cord-342808-yonbowkb 82 109 carcinoma carcinoma NN cord-342808-yonbowkb 82 110 in in IN cord-342808-yonbowkb 82 111 patients patient NNS cord-342808-yonbowkb 82 112 with with IN cord-342808-yonbowkb 82 113 Budd Budd NNP cord-342808-yonbowkb 82 114 - - HYPH cord-342808-yonbowkb 82 115 Chiari Chiari NNP cord-342808-yonbowkb 82 116 syndrome syndrome NN cord-342808-yonbowkb 82 117 Evaluation Evaluation NNP cord-342808-yonbowkb 82 118 of of IN cord-342808-yonbowkb 82 119 liver liver NN cord-342808-yonbowkb 82 120 tumour tumour NN cord-342808-yonbowkb 82 121 response response NN cord-342808-yonbowkb 82 122 by by IN cord-342808-yonbowkb 82 123 imaging image VBG