id sid tid token lemma pos cord-018225-dozmy3lb 1 1 key key JJ cord-018225-dozmy3lb 2 1 : : : cord-018225-dozmy3lb 2 2 cord-018225-dozmy3 cord-018225-dozmy3 NNS cord-018225-dozmy3lb 2 3 lb lb CD cord-018225-dozmy3lb 2 4 authors author NNS cord-018225-dozmy3lb 2 5 : : : cord-018225-dozmy3lb 2 6 Hawker Hawker NNP cord-018225-dozmy3lb 2 7 , , , cord-018225-dozmy3lb 2 8 Felicity Felicity NNP cord-018225-dozmy3lb 2 9 H. H. NNP cord-018225-dozmy3lb 2 10 title title NN cord-018225-dozmy3lb 2 11 : : : cord-018225-dozmy3lb 3 1 The the DT cord-018225-dozmy3lb 3 2 liver liver NN cord-018225-dozmy3lb 3 3 in in IN cord-018225-dozmy3lb 3 4 critical critical JJ cord-018225-dozmy3lb 3 5 illness illness NN cord-018225-dozmy3lb 3 6 date date NN cord-018225-dozmy3lb 3 7 : : : cord-018225-dozmy3lb 3 8 2008 2008 CD cord-018225-dozmy3lb 3 9 journal journal NN cord-018225-dozmy3lb 3 10 : : : cord-018225-dozmy3lb 4 1 Classic Classic NNP cord-018225-dozmy3lb 4 2 Papers Papers NNPS cord-018225-dozmy3lb 4 3 in in IN cord-018225-dozmy3lb 4 4 Critical Critical NNP cord-018225-dozmy3lb 4 5 Care Care NNP cord-018225-dozmy3lb 4 6 DOI doi NN cord-018225-dozmy3lb 4 7 : : : cord-018225-dozmy3lb 5 1 10.1007/978 10.1007/978 LS cord-018225-dozmy3lb 5 2 - - HYPH cord-018225-dozmy3lb 5 3 1 1 CD cord-018225-dozmy3lb 5 4 - - HYPH cord-018225-dozmy3lb 5 5 84800 84800 CD cord-018225-dozmy3lb 5 6 - - HYPH cord-018225-dozmy3lb 5 7 145 145 CD cord-018225-dozmy3lb 5 8 - - SYM cord-018225-dozmy3lb 5 9 9_7 9_7 CD cord-018225-dozmy3lb 5 10 sha sha NN cord-018225-dozmy3lb 5 11 : : : cord-018225-dozmy3lb 5 12 fa376fe4029ec54f3f0d02ef97ec0f18a3361ce3 fa376fe4029ec54f3f0d02ef97ec0f18a3361ce3 NNP cord-018225-dozmy3lb 5 13 doc_id doc_id NNP cord-018225-dozmy3lb 5 14 : : : cord-018225-dozmy3lb 5 15 18225 18225 CD cord-018225-dozmy3lb 5 16 cord_uid cord_uid NNS cord-018225-dozmy3lb 5 17 : : : cord-018225-dozmy3lb 6 1 dozmy3 dozmy3 NNP cord-018225-dozmy3lb 6 2 lb lb IN cord-018225-dozmy3lb 7 1 The the DT cord-018225-dozmy3lb 7 2 liver liver NN cord-018225-dozmy3lb 7 3 is be VBZ cord-018225-dozmy3lb 7 4 in in IN cord-018225-dozmy3lb 7 5 some some DT cord-018225-dozmy3lb 7 6 ways way NNS cord-018225-dozmy3lb 7 7 the the DT cord-018225-dozmy3lb 7 8 forgotten forget VBN cord-018225-dozmy3lb 7 9 organ organ NN cord-018225-dozmy3lb 7 10 in in IN cord-018225-dozmy3lb 7 11 intensive intensive JJ cord-018225-dozmy3lb 7 12 care care NN cord-018225-dozmy3lb 7 13 practice practice NN cord-018225-dozmy3lb 7 14 . . . cord-018225-dozmy3lb 8 1 Very very RB cord-018225-dozmy3lb 8 2 many many JJ cord-018225-dozmy3lb 8 3 more more JJR cord-018225-dozmy3lb 8 4 laboratory laboratory NN cord-018225-dozmy3lb 8 5 and and CC cord-018225-dozmy3lb 8 6 clinical clinical JJ cord-018225-dozmy3lb 8 7 studies study NNS cord-018225-dozmy3lb 8 8 have have VBP cord-018225-dozmy3lb 8 9 investigated investigate VBN cord-018225-dozmy3lb 8 10 the the DT cord-018225-dozmy3lb 8 11 role role NN cord-018225-dozmy3lb 8 12 , , , cord-018225-dozmy3lb 8 13 function function NN cord-018225-dozmy3lb 8 14 , , , cord-018225-dozmy3lb 8 15 and and CC cord-018225-dozmy3lb 8 16 support support NN cord-018225-dozmy3lb 8 17 of of IN cord-018225-dozmy3lb 8 18 the the DT cord-018225-dozmy3lb 8 19 lung lung NN cord-018225-dozmy3lb 8 20 , , , cord-018225-dozmy3lb 8 21 heart heart NN cord-018225-dozmy3lb 8 22 , , , cord-018225-dozmy3lb 8 23 brain brain NN cord-018225-dozmy3lb 8 24 , , , cord-018225-dozmy3lb 8 25 and and CC cord-018225-dozmy3lb 8 26 kidney kidney NN cord-018225-dozmy3lb 8 27 in in IN cord-018225-dozmy3lb 8 28 critical critical JJ cord-018225-dozmy3lb 8 29 illness illness NN cord-018225-dozmy3lb 8 30 than than IN cord-018225-dozmy3lb 8 31 have have VBP cord-018225-dozmy3lb 8 32 studied study VBN cord-018225-dozmy3lb 8 33 the the DT cord-018225-dozmy3lb 8 34 liver liver NN cord-018225-dozmy3lb 8 35 . . . cord-018225-dozmy3lb 9 1 Nevertheless nevertheless RB cord-018225-dozmy3lb 9 2 , , , cord-018225-dozmy3lb 9 3 in in IN cord-018225-dozmy3lb 9 4 the the DT cord-018225-dozmy3lb 9 5 time time NN cord-018225-dozmy3lb 9 6 of of IN cord-018225-dozmy3lb 9 7 the the DT cord-018225-dozmy3lb 9 8 Greek greek JJ cord-018225-dozmy3lb 9 9 scholars scholar NNS cord-018225-dozmy3lb 9 10 , , , cord-018225-dozmy3lb 9 11 there there EX cord-018225-dozmy3lb 9 12 was be VBD cord-018225-dozmy3lb 9 13 already already RB cord-018225-dozmy3lb 9 14 acknowledgement acknowledgement NN cord-018225-dozmy3lb 9 15 of of IN cord-018225-dozmy3lb 9 16 the the DT cord-018225-dozmy3lb 9 17 role role NN cord-018225-dozmy3lb 9 18 of of IN cord-018225-dozmy3lb 9 19 the the DT cord-018225-dozmy3lb 9 20 liver liver NN cord-018225-dozmy3lb 9 21 in in IN cord-018225-dozmy3lb 9 22 non non JJ cord-018225-dozmy3lb 9 23 - - JJ cord-018225-dozmy3lb 9 24 hepatic hepatic JJ cord-018225-dozmy3lb 9 25 diseases disease NNS cord-018225-dozmy3lb 9 26 such such JJ cord-018225-dozmy3lb 9 27 as as IN cord-018225-dozmy3lb 9 28 systemic systemic JJ cord-018225-dozmy3lb 9 29 sepsis sepsis NN cord-018225-dozmy3lb 9 30 , , , cord-018225-dozmy3lb 9 31 and and CC cord-018225-dozmy3lb 9 32 an an DT cord-018225-dozmy3lb 9 33 understanding understanding NN cord-018225-dozmy3lb 9 34 that that IN cord-018225-dozmy3lb 9 35 such such JJ cord-018225-dozmy3lb 9 36 involvement involvement NN cord-018225-dozmy3lb 9 37 confers confer VBZ cord-018225-dozmy3lb 9 38 a a DT cord-018225-dozmy3lb 9 39 poorer poor JJR cord-018225-dozmy3lb 9 40 prognosis prognosis NN cord-018225-dozmy3lb 9 41 – – : cord-018225-dozmy3lb 9 42 hence hence RB cord-018225-dozmy3lb 9 43 the the DT cord-018225-dozmy3lb 9 44 inclusion inclusion NN cord-018225-dozmy3lb 9 45 of of IN cord-018225-dozmy3lb 9 46 the the DT cord-018225-dozmy3lb 9 47 wisdom wisdom NN cord-018225-dozmy3lb 9 48 of of IN cord-018225-dozmy3lb 9 49 Hippocrates Hippocrates NNP cord-018225-dozmy3lb 9 50 in in IN cord-018225-dozmy3lb 9 51 this this DT cord-018225-dozmy3lb 9 52 compilation compilation NN cord-018225-dozmy3lb 9 53 of of IN cord-018225-dozmy3lb 9 54 classic classic JJ cord-018225-dozmy3lb 9 55 papers paper NNS cord-018225-dozmy3lb 9 56 . . . cord-018225-dozmy3lb 10 1 In in IN cord-018225-dozmy3lb 10 2 the the DT cord-018225-dozmy3lb 10 3 review review NN cord-018225-dozmy3lb 10 4 article article NN cord-018225-dozmy3lb 10 5 by by IN cord-018225-dozmy3lb 10 6 Matuschak Matuschak NNP cord-018225-dozmy3lb 10 7 and and CC cord-018225-dozmy3lb 10 8 Rinaldo Rinaldo NNP cord-018225-dozmy3lb 10 9 , , , cord-018225-dozmy3lb 10 10 the the DT cord-018225-dozmy3lb 10 11 reasons reason NNS cord-018225-dozmy3lb 10 12 why why WRB cord-018225-dozmy3lb 10 13 liver liver NN cord-018225-dozmy3lb 10 14 dysfunction dysfunction NN cord-018225-dozmy3lb 10 15 is be VBZ cord-018225-dozmy3lb 10 16 associated associate VBN cord-018225-dozmy3lb 10 17 with with IN cord-018225-dozmy3lb 10 18 a a DT cord-018225-dozmy3lb 10 19 poorer poor JJR cord-018225-dozmy3lb 10 20 outcome outcome NN cord-018225-dozmy3lb 10 21 in in IN cord-018225-dozmy3lb 10 22 critical critical JJ cord-018225-dozmy3lb 10 23 illness illness NN cord-018225-dozmy3lb 10 24 are be VBP cord-018225-dozmy3lb 10 25 explored explore VBN cord-018225-dozmy3lb 10 26 , , , cord-018225-dozmy3lb 10 27 and and CC cord-018225-dozmy3lb 10 28 the the DT cord-018225-dozmy3lb 10 29 concept concept NN cord-018225-dozmy3lb 10 30 of of IN cord-018225-dozmy3lb 10 31 the the DT cord-018225-dozmy3lb 10 32 liver liver NN cord-018225-dozmy3lb 10 33 being be VBG cord-018225-dozmy3lb 10 34 a a DT cord-018225-dozmy3lb 10 35 ‘ ' `` cord-018225-dozmy3lb 10 36 driving drive VBG cord-018225-dozmy3lb 10 37 force force NN cord-018225-dozmy3lb 10 38 ’ ' '' cord-018225-dozmy3lb 10 39 in in IN cord-018225-dozmy3lb 10 40 multiple multiple JJ cord-018225-dozmy3lb 10 41 organ organ NN cord-018225-dozmy3lb 10 42 dysfunction dysfunction NN cord-018225-dozmy3lb 10 43 is be VBZ cord-018225-dozmy3lb 10 44 developed develop VBN cord-018225-dozmy3lb 10 45 . . . cord-018225-dozmy3lb 11 1 In in IN cord-018225-dozmy3lb 11 2 addition addition NN cord-018225-dozmy3lb 11 3 , , , cord-018225-dozmy3lb 11 4 jaundice jaundice NN cord-018225-dozmy3lb 11 5 without without IN cord-018225-dozmy3lb 11 6 significant significant JJ cord-018225-dozmy3lb 11 7 liver liver NN cord-018225-dozmy3lb 11 8 dysfunction dysfunction NN cord-018225-dozmy3lb 11 9 is be VBZ cord-018225-dozmy3lb 11 10 associated associate VBN cord-018225-dozmy3lb 11 11 with with IN cord-018225-dozmy3lb 11 12 left left JJ cord-018225-dozmy3lb 11 13 ventricular ventricular JJ cord-018225-dozmy3lb 11 14 dysfunction dysfunction NN cord-018225-dozmy3lb 11 15 , , , cord-018225-dozmy3lb 11 16 at at IN cord-018225-dozmy3lb 11 17 least least JJS cord-018225-dozmy3lb 11 18 in in IN cord-018225-dozmy3lb 11 19 the the DT cord-018225-dozmy3lb 11 20 dog dog NN cord-018225-dozmy3lb 11 21 model model NN cord-018225-dozmy3lb 11 22 developed develop VBN cord-018225-dozmy3lb 11 23 by by IN cord-018225-dozmy3lb 11 24 Professor Professor NNP cord-018225-dozmy3lb 11 25 Otto Otto NNP cord-018225-dozmy3lb 11 26 Better Better NNP cord-018225-dozmy3lb 11 27 and and CC cord-018225-dozmy3lb 11 28 his -PRON- PRP$ cord-018225-dozmy3lb 11 29 colleagues colleague NNS cord-018225-dozmy3lb 11 30 in in IN cord-018225-dozmy3lb 11 31 Israel Israel NNP cord-018225-dozmy3lb 11 32 . . . cord-018225-dozmy3lb 12 1 This this DT cord-018225-dozmy3lb 12 2 observation observation NN cord-018225-dozmy3lb 12 3 is be VBZ cord-018225-dozmy3lb 12 4 relevant relevant JJ cord-018225-dozmy3lb 12 5 to to IN cord-018225-dozmy3lb 12 6 the the DT cord-018225-dozmy3lb 12 7 progressive progressive JJ cord-018225-dozmy3lb 12 8 resistance resistance NN cord-018225-dozmy3lb 12 9 to to IN cord-018225-dozmy3lb 12 10 inotropic inotropic NNP cord-018225-dozmy3lb 12 11 and and CC cord-018225-dozmy3lb 12 12 vasopressor vasopressor NN cord-018225-dozmy3lb 12 13 agents agent NNS cord-018225-dozmy3lb 12 14 in in IN cord-018225-dozmy3lb 12 15 jaundiced jaundiced JJ cord-018225-dozmy3lb 12 16 critically critically RB cord-018225-dozmy3lb 12 17 ill ill JJ cord-018225-dozmy3lb 12 18 patients patient NNS cord-018225-dozmy3lb 12 19 . . . cord-018225-dozmy3lb 13 1 The the DT cord-018225-dozmy3lb 13 2 liver liver NN cord-018225-dozmy3lb 13 3 is be VBZ cord-018225-dozmy3lb 13 4 in in IN cord-018225-dozmy3lb 13 5 some some DT cord-018225-dozmy3lb 13 6 ways way NNS cord-018225-dozmy3lb 13 7 the the DT cord-018225-dozmy3lb 13 8 forgotten forget VBN cord-018225-dozmy3lb 13 9 organ organ NN cord-018225-dozmy3lb 13 10 in in IN cord-018225-dozmy3lb 13 11 intensive intensive JJ cord-018225-dozmy3lb 13 12 care care NN cord-018225-dozmy3lb 13 13 practice practice NN cord-018225-dozmy3lb 13 14 . . . cord-018225-dozmy3lb 14 1 Very very RB cord-018225-dozmy3lb 14 2 many many JJ cord-018225-dozmy3lb 14 3 more more JJR cord-018225-dozmy3lb 14 4 laboratory laboratory NN cord-018225-dozmy3lb 14 5 and and CC cord-018225-dozmy3lb 14 6 clinical clinical JJ cord-018225-dozmy3lb 14 7 studies study NNS cord-018225-dozmy3lb 14 8 have have VBP cord-018225-dozmy3lb 14 9 investigated investigate VBN cord-018225-dozmy3lb 14 10 the the DT cord-018225-dozmy3lb 14 11 role role NN cord-018225-dozmy3lb 14 12 , , , cord-018225-dozmy3lb 14 13 function function NN cord-018225-dozmy3lb 14 14 , , , cord-018225-dozmy3lb 14 15 and and CC cord-018225-dozmy3lb 14 16 support support NN cord-018225-dozmy3lb 14 17 of of IN cord-018225-dozmy3lb 14 18 the the DT cord-018225-dozmy3lb 14 19 lung lung NN cord-018225-dozmy3lb 14 20 , , , cord-018225-dozmy3lb 14 21 heart heart NN cord-018225-dozmy3lb 14 22 , , , cord-018225-dozmy3lb 14 23 brain brain NN cord-018225-dozmy3lb 14 24 , , , cord-018225-dozmy3lb 14 25 and and CC cord-018225-dozmy3lb 14 26 kidney kidney NN cord-018225-dozmy3lb 14 27 in in IN cord-018225-dozmy3lb 14 28 critical critical JJ cord-018225-dozmy3lb 14 29 illness illness NN cord-018225-dozmy3lb 14 30 than than IN cord-018225-dozmy3lb 14 31 have have VBP cord-018225-dozmy3lb 14 32 studied study VBN cord-018225-dozmy3lb 14 33 the the DT cord-018225-dozmy3lb 14 34 liver liver NN cord-018225-dozmy3lb 14 35 . . . cord-018225-dozmy3lb 15 1 Nevertheless nevertheless RB cord-018225-dozmy3lb 15 2 , , , cord-018225-dozmy3lb 15 3 in in IN cord-018225-dozmy3lb 15 4 the the DT cord-018225-dozmy3lb 15 5 time time NN cord-018225-dozmy3lb 15 6 of of IN cord-018225-dozmy3lb 15 7 the the DT cord-018225-dozmy3lb 15 8 Greek greek JJ cord-018225-dozmy3lb 15 9 scholars scholar NNS cord-018225-dozmy3lb 15 10 , , , cord-018225-dozmy3lb 15 11 there there EX cord-018225-dozmy3lb 15 12 was be VBD cord-018225-dozmy3lb 15 13 already already RB cord-018225-dozmy3lb 15 14 acknowledgement acknowledgement NN cord-018225-dozmy3lb 15 15 of of IN cord-018225-dozmy3lb 15 16 the the DT cord-018225-dozmy3lb 15 17 role role NN cord-018225-dozmy3lb 15 18 of of IN cord-018225-dozmy3lb 15 19 the the DT cord-018225-dozmy3lb 15 20 liver liver NN cord-018225-dozmy3lb 15 21 in in IN cord-018225-dozmy3lb 15 22 non non JJ cord-018225-dozmy3lb 15 23 - - JJ cord-018225-dozmy3lb 15 24 hepatic hepatic JJ cord-018225-dozmy3lb 15 25 diseases disease NNS cord-018225-dozmy3lb 15 26 such such JJ cord-018225-dozmy3lb 15 27 as as IN cord-018225-dozmy3lb 15 28 systemic systemic JJ cord-018225-dozmy3lb 15 29 sepsis sepsis NN cord-018225-dozmy3lb 15 30 , , , cord-018225-dozmy3lb 15 31 and and CC cord-018225-dozmy3lb 15 32 an an DT cord-018225-dozmy3lb 15 33 understanding understanding NN cord-018225-dozmy3lb 15 34 that that IN cord-018225-dozmy3lb 15 35 such such JJ cord-018225-dozmy3lb 15 36 involvement involvement NN cord-018225-dozmy3lb 15 37 confers confer VBZ cord-018225-dozmy3lb 15 38 a a DT cord-018225-dozmy3lb 15 39 poorer poor JJR cord-018225-dozmy3lb 15 40 prognosis prognosis NN cord-018225-dozmy3lb 16 1 -hence -hence : cord-018225-dozmy3lb 17 1 the the DT cord-018225-dozmy3lb 17 2 inclusion inclusion NN cord-018225-dozmy3lb 17 3 of of IN cord-018225-dozmy3lb 17 4 the the DT cord-018225-dozmy3lb 17 5 wisdom wisdom NN cord-018225-dozmy3lb 17 6 of of IN cord-018225-dozmy3lb 17 7 Hippocrates Hippocrates NNP cord-018225-dozmy3lb 17 8 in in IN cord-018225-dozmy3lb 17 9 this this DT cord-018225-dozmy3lb 17 10 compilation compilation NN cord-018225-dozmy3lb 17 11 of of IN cord-018225-dozmy3lb 17 12 classic classic JJ cord-018225-dozmy3lb 17 13 papers paper NNS cord-018225-dozmy3lb 17 14 . . . cord-018225-dozmy3lb 18 1 In in IN cord-018225-dozmy3lb 18 2 the the DT cord-018225-dozmy3lb 18 3 review review NN cord-018225-dozmy3lb 18 4 article article NN cord-018225-dozmy3lb 18 5 by by IN cord-018225-dozmy3lb 18 6 Matuschak Matuschak NNP cord-018225-dozmy3lb 18 7 and and CC cord-018225-dozmy3lb 18 8 Rinaldo Rinaldo NNP cord-018225-dozmy3lb 18 9 , , , cord-018225-dozmy3lb 18 10 the the DT cord-018225-dozmy3lb 18 11 reasons reason NNS cord-018225-dozmy3lb 18 12 why why WRB cord-018225-dozmy3lb 18 13 liver liver NN cord-018225-dozmy3lb 18 14 dysfunction dysfunction NN cord-018225-dozmy3lb 18 15 is be VBZ cord-018225-dozmy3lb 18 16 associated associate VBN cord-018225-dozmy3lb 18 17 with with IN cord-018225-dozmy3lb 18 18 a a DT cord-018225-dozmy3lb 18 19 poorer poor JJR cord-018225-dozmy3lb 18 20 outcome outcome NN cord-018225-dozmy3lb 18 21 in in IN cord-018225-dozmy3lb 18 22 critical critical JJ cord-018225-dozmy3lb 18 23 illness illness NN cord-018225-dozmy3lb 18 24 are be VBP cord-018225-dozmy3lb 18 25 explored explore VBN cord-018225-dozmy3lb 18 26 , , , cord-018225-dozmy3lb 18 27 and and CC cord-018225-dozmy3lb 18 28 the the DT cord-018225-dozmy3lb 18 29 concept concept NN cord-018225-dozmy3lb 18 30 of of IN cord-018225-dozmy3lb 18 31 the the DT cord-018225-dozmy3lb 18 32 liver liver NN cord-018225-dozmy3lb 18 33 being be VBG cord-018225-dozmy3lb 18 34 a a DT cord-018225-dozmy3lb 18 35 ' ' `` cord-018225-dozmy3lb 18 36 driving drive VBG cord-018225-dozmy3lb 18 37 force force NN cord-018225-dozmy3lb 18 38 ' ' '' cord-018225-dozmy3lb 18 39 in in IN cord-018225-dozmy3lb 18 40 multiple multiple JJ cord-018225-dozmy3lb 18 41 organ organ NN cord-018225-dozmy3lb 18 42 dysfunction dysfunction NN cord-018225-dozmy3lb 18 43 is be VBZ cord-018225-dozmy3lb 18 44 developed develop VBN cord-018225-dozmy3lb 18 45 . . . cord-018225-dozmy3lb 19 1 In in IN cord-018225-dozmy3lb 19 2 addition addition NN cord-018225-dozmy3lb 19 3 , , , cord-018225-dozmy3lb 19 4 jaundice jaundice NN cord-018225-dozmy3lb 19 5 without without IN cord-018225-dozmy3lb 19 6 significant significant JJ cord-018225-dozmy3lb 19 7 liver liver NN cord-018225-dozmy3lb 19 8 dysfunction dysfunction NN cord-018225-dozmy3lb 19 9 is be VBZ cord-018225-dozmy3lb 19 10 associated associate VBN cord-018225-dozmy3lb 19 11 with with IN cord-018225-dozmy3lb 19 12 left left JJ cord-018225-dozmy3lb 19 13 ventricular ventricular JJ cord-018225-dozmy3lb 19 14 dysfunction dysfunction NN cord-018225-dozmy3lb 19 15 , , , cord-018225-dozmy3lb 19 16 at at IN cord-018225-dozmy3lb 19 17 least least JJS cord-018225-dozmy3lb 19 18 in in IN cord-018225-dozmy3lb 19 19 the the DT cord-018225-dozmy3lb 19 20 dog dog NN cord-018225-dozmy3lb 19 21 model model NN cord-018225-dozmy3lb 19 22 developed develop VBN cord-018225-dozmy3lb 19 23 by by IN cord-018225-dozmy3lb 19 24 Professor Professor NNP cord-018225-dozmy3lb 19 25 Otto Otto NNP cord-018225-dozmy3lb 19 26 Better Better NNP cord-018225-dozmy3lb 19 27 and and CC cord-018225-dozmy3lb 19 28 his -PRON- PRP$ cord-018225-dozmy3lb 19 29 colleagues colleague NNS cord-018225-dozmy3lb 19 30 in in IN cord-018225-dozmy3lb 19 31 Israel Israel NNP cord-018225-dozmy3lb 19 32 . . . cord-018225-dozmy3lb 20 1 This this DT cord-018225-dozmy3lb 20 2 observation observation NN cord-018225-dozmy3lb 20 3 is be VBZ cord-018225-dozmy3lb 20 4 relevant relevant JJ cord-018225-dozmy3lb 20 5 to to IN cord-018225-dozmy3lb 20 6 the the DT cord-018225-dozmy3lb 20 7 progressive progressive JJ cord-018225-dozmy3lb 20 8 resistance resistance NN cord-018225-dozmy3lb 20 9 to to IN cord-018225-dozmy3lb 20 10 inotropic inotropic NNP cord-018225-dozmy3lb 20 11 and and CC cord-018225-dozmy3lb 20 12 vasopressor vasopressor NN cord-018225-dozmy3lb 20 13 agents agent NNS cord-018225-dozmy3lb 20 14 in in IN cord-018225-dozmy3lb 20 15 jaundiced jaundiced JJ cord-018225-dozmy3lb 20 16 critically critically RB cord-018225-dozmy3lb 20 17 ill ill JJ cord-018225-dozmy3lb 20 18 patients patient NNS cord-018225-dozmy3lb 20 19 . . . cord-018225-dozmy3lb 21 1 One one CD cord-018225-dozmy3lb 21 2 of of IN cord-018225-dozmy3lb 21 3 the the DT cord-018225-dozmy3lb 21 4 most most RBS cord-018225-dozmy3lb 21 5 devastating devastating JJ cord-018225-dozmy3lb 21 6 insults insult NNS cord-018225-dozmy3lb 21 7 that that WDT cord-018225-dozmy3lb 21 8 can can MD cord-018225-dozmy3lb 21 9 occur occur VB cord-018225-dozmy3lb 21 10 in in IN cord-018225-dozmy3lb 21 11 critical critical JJ cord-018225-dozmy3lb 21 12 illness illness NN cord-018225-dozmy3lb 21 13 is be VBZ cord-018225-dozmy3lb 21 14 acute acute JJ cord-018225-dozmy3lb 21 15 liver liver NN cord-018225-dozmy3lb 21 16 ischemia ischemia NN cord-018225-dozmy3lb 21 17 , , , cord-018225-dozmy3lb 21 18 resulting result VBG cord-018225-dozmy3lb 21 19 in in IN cord-018225-dozmy3lb 21 20 the the DT cord-018225-dozmy3lb 21 21 clinical clinical JJ cord-018225-dozmy3lb 21 22 syndrome syndrome NN cord-018225-dozmy3lb 21 23 of of IN cord-018225-dozmy3lb 21 24 ischemic ischemic JJ cord-018225-dozmy3lb 21 25 or or CC cord-018225-dozmy3lb 21 26 hypoxic hypoxic JJ cord-018225-dozmy3lb 21 27 hepatitis hepatitis NN cord-018225-dozmy3lb 21 28 . . . cord-018225-dozmy3lb 22 1 Although although IN cord-018225-dozmy3lb 22 2 relatively relatively RB cord-018225-dozmy3lb 22 3 common common JJ cord-018225-dozmy3lb 22 4 , , , cord-018225-dozmy3lb 22 5 this this DT cord-018225-dozmy3lb 22 6 syndrome syndrome NN cord-018225-dozmy3lb 22 7 has have VBZ cord-018225-dozmy3lb 22 8 been be VBN cord-018225-dozmy3lb 22 9 difficult difficult JJ cord-018225-dozmy3lb 22 10 to to TO cord-018225-dozmy3lb 22 11 study study VB cord-018225-dozmy3lb 22 12 prospectively prospectively RB cord-018225-dozmy3lb 22 13 . . . cord-018225-dozmy3lb 23 1 Consequently consequently RB cord-018225-dozmy3lb 23 2 , , , cord-018225-dozmy3lb 23 3 the the DT cord-018225-dozmy3lb 23 4 paper paper NN cord-018225-dozmy3lb 23 5 by by IN cord-018225-dozmy3lb 23 6 Jean Jean NNP cord-018225-dozmy3lb 23 7 Henrion Henrion NNP cord-018225-dozmy3lb 23 8 from from IN cord-018225-dozmy3lb 23 9 Belgium Belgium NNP cord-018225-dozmy3lb 23 10 offers offer VBZ cord-018225-dozmy3lb 23 11 new new JJ cord-018225-dozmy3lb 23 12 insights insight NNS cord-018225-dozmy3lb 23 13 into into IN cord-018225-dozmy3lb 23 14 the the DT cord-018225-dozmy3lb 23 15 hemodynamic hemodynamic JJ cord-018225-dozmy3lb 23 16 associations association NNS cord-018225-dozmy3lb 23 17 of of IN cord-018225-dozmy3lb 23 18 ischemic ischemic JJ cord-018225-dozmy3lb 23 19 hepatitis hepatitis NN cord-018225-dozmy3lb 23 20 , , , cord-018225-dozmy3lb 23 21 which which WDT cord-018225-dozmy3lb 23 22 is be VBZ cord-018225-dozmy3lb 23 23 , , , cord-018225-dozmy3lb 23 24 of of IN cord-018225-dozmy3lb 23 25 course course NN cord-018225-dozmy3lb 23 26 , , , cord-018225-dozmy3lb 23 27 a a DT cord-018225-dozmy3lb 23 28 circulatory circulatory JJ cord-018225-dozmy3lb 23 29 disease disease NN cord-018225-dozmy3lb 23 30 , , , cord-018225-dozmy3lb 23 31 not not RB cord-018225-dozmy3lb 23 32 a a DT cord-018225-dozmy3lb 23 33 liver liver NN cord-018225-dozmy3lb 23 34 disease disease NN cord-018225-dozmy3lb 23 35 . . . cord-018225-dozmy3lb 24 1 Commonly commonly RB cord-018225-dozmy3lb 24 2 used use VBN cord-018225-dozmy3lb 24 3 ' ' '' cord-018225-dozmy3lb 24 4 liver liver NN cord-018225-dozmy3lb 24 5 function function NN cord-018225-dozmy3lb 24 6 tests test NNS cord-018225-dozmy3lb 24 7 ' ' POS cord-018225-dozmy3lb 24 8 assess assess VB cord-018225-dozmy3lb 24 9 damage damage NN cord-018225-dozmy3lb 24 10 to to IN cord-018225-dozmy3lb 24 11 the the DT cord-018225-dozmy3lb 24 12 liver liver NN cord-018225-dozmy3lb 24 13 rather rather RB cord-018225-dozmy3lb 24 14 than than IN cord-018225-dozmy3lb 24 15 its -PRON- PRP$ cord-018225-dozmy3lb 24 16 function function NN cord-018225-dozmy3lb 24 17 . . . cord-018225-dozmy3lb 25 1 An an DT cord-018225-dozmy3lb 25 2 understanding understanding NN cord-018225-dozmy3lb 25 3 of of IN cord-018225-dozmy3lb 25 4 the the DT cord-018225-dozmy3lb 25 5 complex complex JJ cord-018225-dozmy3lb 25 6 relationship relationship NN cord-018225-dozmy3lb 25 7 between between IN cord-018225-dozmy3lb 25 8 critical critical JJ cord-018225-dozmy3lb 25 9 illness illness NN cord-018225-dozmy3lb 25 10 and and CC cord-018225-dozmy3lb 25 11 liver liver NN cord-018225-dozmy3lb 25 12 dysfunction dysfunction NN cord-018225-dozmy3lb 25 13 has have VBZ cord-018225-dozmy3lb 25 14 been be VBN cord-018225-dozmy3lb 25 15 hampered hamper VBN cord-018225-dozmy3lb 25 16 by by IN cord-018225-dozmy3lb 25 17 the the DT cord-018225-dozmy3lb 25 18 absence absence NN cord-018225-dozmy3lb 25 19 of of IN cord-018225-dozmy3lb 25 20 a a DT cord-018225-dozmy3lb 25 21 simple simple JJ cord-018225-dozmy3lb 25 22 test test NN cord-018225-dozmy3lb 25 23 that that WDT cord-018225-dozmy3lb 25 24 assesses assess VBZ cord-018225-dozmy3lb 25 25 at at RB cord-018225-dozmy3lb 25 26 least least RBS cord-018225-dozmy3lb 25 27 one one CD cord-018225-dozmy3lb 25 28 of of IN cord-018225-dozmy3lb 25 29 the the DT cord-018225-dozmy3lb 25 30 many many JJ cord-018225-dozmy3lb 25 31 functions function NNS cord-018225-dozmy3lb 25 32 of of IN cord-018225-dozmy3lb 25 33 the the DT cord-018225-dozmy3lb 25 34 liver liver NN cord-018225-dozmy3lb 25 35 . . . cord-018225-dozmy3lb 26 1 The the DT cord-018225-dozmy3lb 26 2 MEGX MEGX NNP cord-018225-dozmy3lb 26 3 test test NN cord-018225-dozmy3lb 26 4 , , , cord-018225-dozmy3lb 26 5 developed develop VBN cord-018225-dozmy3lb 26 6 by by IN cord-018225-dozmy3lb 26 7 Oellerich Oellerich NNP cord-018225-dozmy3lb 26 8 and and CC cord-018225-dozmy3lb 26 9 co co NNS cord-018225-dozmy3lb 26 10 - - NNS cord-018225-dozmy3lb 26 11 workers worker NNS cord-018225-dozmy3lb 26 12 in in IN cord-018225-dozmy3lb 26 13 Germany Germany NNP cord-018225-dozmy3lb 26 14 , , , cord-018225-dozmy3lb 26 15 allows allow VBZ cord-018225-dozmy3lb 26 16 dynamic dynamic JJ cord-018225-dozmy3lb 26 17 assessment assessment NN cord-018225-dozmy3lb 26 18 of of IN cord-018225-dozmy3lb 26 19 liver liver NN cord-018225-dozmy3lb 26 20 function function NN cord-018225-dozmy3lb 26 21 , , , cord-018225-dozmy3lb 26 22 and and CC cord-018225-dozmy3lb 26 23 may may MD cord-018225-dozmy3lb 26 24 prove prove VB cord-018225-dozmy3lb 26 25 useful useful JJ cord-018225-dozmy3lb 26 26 in in IN cord-018225-dozmy3lb 26 27 the the DT cord-018225-dozmy3lb 26 28 evaluation evaluation NN cord-018225-dozmy3lb 26 29 of of IN cord-018225-dozmy3lb 26 30 therapies therapy NNS cord-018225-dozmy3lb 26 31 to to TO cord-018225-dozmy3lb 26 32 support support VB cord-018225-dozmy3lb 26 33 liver liver NN cord-018225-dozmy3lb 26 34 function function NN cord-018225-dozmy3lb 26 35 in in IN cord-018225-dozmy3lb 26 36 critical critical JJ cord-018225-dozmy3lb 26 37 illness illness NN cord-018225-dozmy3lb 26 38 . . . cord-018225-dozmy3lb 27 1 The the DT cord-018225-dozmy3lb 27 2 complex complex JJ cord-018225-dozmy3lb 27 3 issues issue NNS cord-018225-dozmy3lb 27 4 involved involve VBN cord-018225-dozmy3lb 27 5 in in IN cord-018225-dozmy3lb 27 6 the the DT cord-018225-dozmy3lb 27 7 management management NN cord-018225-dozmy3lb 27 8 of of IN cord-018225-dozmy3lb 27 9 patients patient NNS cord-018225-dozmy3lb 27 10 with with IN cord-018225-dozmy3lb 27 11 acute acute JJ cord-018225-dozmy3lb 27 12 liver liver NN cord-018225-dozmy3lb 27 13 failure failure NN cord-018225-dozmy3lb 27 14 exemplify exemplify VBP cord-018225-dozmy3lb 27 15 the the DT cord-018225-dozmy3lb 27 16 many many JJ cord-018225-dozmy3lb 27 17 important important JJ cord-018225-dozmy3lb 27 18 functions function NNS cord-018225-dozmy3lb 27 19 of of IN cord-018225-dozmy3lb 27 20 the the DT cord-018225-dozmy3lb 27 21 healthy healthy JJ cord-018225-dozmy3lb 27 22 liver liver NN cord-018225-dozmy3lb 27 23 . . . cord-018225-dozmy3lb 28 1 With with IN cord-018225-dozmy3lb 28 2 the the DT cord-018225-dozmy3lb 28 3 advent advent NN cord-018225-dozmy3lb 28 4 of of IN cord-018225-dozmy3lb 28 5 liver liver NN cord-018225-dozmy3lb 28 6 transplantation transplantation NN cord-018225-dozmy3lb 28 7 as as IN cord-018225-dozmy3lb 28 8 the the DT cord-018225-dozmy3lb 28 9 principle principle JJ cord-018225-dozmy3lb 28 10 treatment treatment NN cord-018225-dozmy3lb 28 11 for for IN cord-018225-dozmy3lb 28 12 patients patient NNS cord-018225-dozmy3lb 28 13 with with IN cord-018225-dozmy3lb 28 14 fulminant fulminant JJ cord-018225-dozmy3lb 28 15 hepatic hepatic JJ cord-018225-dozmy3lb 28 16 failure failure NN cord-018225-dozmy3lb 28 17 , , , cord-018225-dozmy3lb 28 18 these these DT cord-018225-dozmy3lb 28 19 patients patient NNS cord-018225-dozmy3lb 28 20 are be VBP cord-018225-dozmy3lb 28 21 almost almost RB cord-018225-dozmy3lb 28 22 always always RB cord-018225-dozmy3lb 28 23 managed manage VBN cord-018225-dozmy3lb 28 24 in in IN cord-018225-dozmy3lb 28 25 ICUs ICUs NNP cord-018225-dozmy3lb 28 26 servicing service VBG cord-018225-dozmy3lb 28 27 liver liver NN cord-018225-dozmy3lb 28 28 transplant transplant NN cord-018225-dozmy3lb 28 29 units unit NNS cord-018225-dozmy3lb 28 30 . . . cord-018225-dozmy3lb 29 1 Consequently consequently RB cord-018225-dozmy3lb 29 2 , , , cord-018225-dozmy3lb 29 3 it -PRON- PRP cord-018225-dozmy3lb 29 4 is be VBZ cord-018225-dozmy3lb 29 5 extremely extremely RB cord-018225-dozmy3lb 29 6 important important JJ cord-018225-dozmy3lb 29 7 that that IN cord-018225-dozmy3lb 29 8 intensive intensive JJ cord-018225-dozmy3lb 29 9 care care NN cord-018225-dozmy3lb 29 10 practitioners practitioner NNS cord-018225-dozmy3lb 29 11 in in IN cord-018225-dozmy3lb 29 12 non non JJ cord-018225-dozmy3lb 29 13 - - JJ cord-018225-dozmy3lb 29 14 liver liver JJ cord-018225-dozmy3lb 29 15 units unit NNS cord-018225-dozmy3lb 29 16 understand understand VBP cord-018225-dozmy3lb 29 17 the the DT cord-018225-dozmy3lb 29 18 need need NN cord-018225-dozmy3lb 29 19 to to TO cord-018225-dozmy3lb 29 20 refer refer VB cord-018225-dozmy3lb 29 21 patients patient NNS cord-018225-dozmy3lb 29 22 to to IN cord-018225-dozmy3lb 29 23 transplant transplant NN cord-018225-dozmy3lb 29 24 units unit NNS cord-018225-dozmy3lb 29 25 , , , cord-018225-dozmy3lb 29 26 as as RB cord-018225-dozmy3lb 29 27 well well RB cord-018225-dozmy3lb 29 28 as as IN cord-018225-dozmy3lb 29 29 the the DT cord-018225-dozmy3lb 29 30 role role NN cord-018225-dozmy3lb 29 31 of of IN cord-018225-dozmy3lb 29 32 transplantation transplantation NN cord-018225-dozmy3lb 29 33 in in IN cord-018225-dozmy3lb 29 34 acute acute JJ cord-018225-dozmy3lb 29 35 liver liver NN cord-018225-dozmy3lb 29 36 failure failure NN cord-018225-dozmy3lb 29 37 and and CC cord-018225-dozmy3lb 29 38 its -PRON- PRP$ cord-018225-dozmy3lb 29 39 indications indication NNS cord-018225-dozmy3lb 29 40 . . . cord-018225-dozmy3lb 30 1 The the DT cord-018225-dozmy3lb 30 2 seminal seminal JJ cord-018225-dozmy3lb 30 3 paper paper NN cord-018225-dozmy3lb 30 4 by by IN cord-018225-dozmy3lb 30 5 O'Grady O'Grady NNP cord-018225-dozmy3lb 30 6 and and CC cord-018225-dozmy3lb 30 7 the the DT cord-018225-dozmy3lb 30 8 group group NN cord-018225-dozmy3lb 30 9 from from IN cord-018225-dozmy3lb 30 10 King King NNP cord-018225-dozmy3lb 30 11 's 's POS cord-018225-dozmy3lb 30 12 College College NNP cord-018225-dozmy3lb 30 13 Hospital Hospital NNP cord-018225-dozmy3lb 30 14 , , , cord-018225-dozmy3lb 30 15 London London NNP cord-018225-dozmy3lb 30 16 , , , cord-018225-dozmy3lb 30 17 develops develop VBZ cord-018225-dozmy3lb 30 18 criteria criterion NNS cord-018225-dozmy3lb 30 19 for for IN cord-018225-dozmy3lb 30 20 liver liver NN cord-018225-dozmy3lb 30 21 transplantation transplantation NN cord-018225-dozmy3lb 30 22 in in IN cord-018225-dozmy3lb 30 23 acute acute JJ cord-018225-dozmy3lb 30 24 liver liver NN cord-018225-dozmy3lb 30 25 failure failure NN cord-018225-dozmy3lb 30 26 . . . cord-018225-dozmy3lb 31 1 That that IN cord-018225-dozmy3lb 31 2 a a DT cord-018225-dozmy3lb 31 3 successful successful JJ cord-018225-dozmy3lb 31 4 outcome outcome NN cord-018225-dozmy3lb 31 5 is be VBZ cord-018225-dozmy3lb 31 6 possible possible JJ cord-018225-dozmy3lb 31 7 after after IN cord-018225-dozmy3lb 31 8 emergency emergency NN cord-018225-dozmy3lb 31 9 liver liver NN cord-018225-dozmy3lb 31 10 transplantation transplantation NN cord-018225-dozmy3lb 31 11 for for IN cord-018225-dozmy3lb 31 12 acute acute JJ cord-018225-dozmy3lb 31 13 liver liver NN cord-018225-dozmy3lb 31 14 failure failure NN cord-018225-dozmy3lb 31 15 is be VBZ cord-018225-dozmy3lb 31 16 shown show VBN cord-018225-dozmy3lb 31 17 in in IN cord-018225-dozmy3lb 31 18 the the DT cord-018225-dozmy3lb 31 19 early early JJ cord-018225-dozmy3lb 31 20 series series NN cord-018225-dozmy3lb 31 21 of of IN cord-018225-dozmy3lb 31 22 cases case NNS cord-018225-dozmy3lb 31 23 reported report VBN cord-018225-dozmy3lb 31 24 from from IN cord-018225-dozmy3lb 31 25 the the DT cord-018225-dozmy3lb 31 26 French french JJ cord-018225-dozmy3lb 31 27 group group NN cord-018225-dozmy3lb 31 28 from from IN cord-018225-dozmy3lb 31 29 Clichy Clichy NNP cord-018225-dozmy3lb 31 30 and and CC cord-018225-dozmy3lb 31 31 Villejuif Villejuif NNP cord-018225-dozmy3lb 31 32 . . . cord-018225-dozmy3lb 32 1 When when WRB cord-018225-dozmy3lb 32 2 transplantation transplantation NN cord-018225-dozmy3lb 32 3 is be VBZ cord-018225-dozmy3lb 32 4 not not RB cord-018225-dozmy3lb 32 5 indicated indicate VBN cord-018225-dozmy3lb 32 6 , , , cord-018225-dozmy3lb 32 7 or or CC cord-018225-dozmy3lb 32 8 while while IN cord-018225-dozmy3lb 32 9 awaiting await VBG cord-018225-dozmy3lb 32 10 a a DT cord-018225-dozmy3lb 32 11 donor donor NN cord-018225-dozmy3lb 32 12 , , , cord-018225-dozmy3lb 32 13 the the DT cord-018225-dozmy3lb 32 14 principal principal JJ cord-018225-dozmy3lb 32 15 treatment treatment NN cord-018225-dozmy3lb 32 16 is be VBZ cord-018225-dozmy3lb 32 17 supportive supportive JJ cord-018225-dozmy3lb 32 18 . . . cord-018225-dozmy3lb 33 1 The the DT cord-018225-dozmy3lb 33 2 paper paper NN cord-018225-dozmy3lb 33 3 by by IN cord-018225-dozmy3lb 33 4 Harrison Harrison NNP cord-018225-dozmy3lb 33 5 and and CC cord-018225-dozmy3lb 33 6 co co NNS cord-018225-dozmy3lb 33 7 - - NNS cord-018225-dozmy3lb 33 8 workers worker NNS cord-018225-dozmy3lb 33 9 , , , cord-018225-dozmy3lb 33 10 again again RB cord-018225-dozmy3lb 33 11 from from IN cord-018225-dozmy3lb 33 12 the the DT cord-018225-dozmy3lb 33 13 King King NNP cord-018225-dozmy3lb 33 14 's 's POS cord-018225-dozmy3lb 33 15 Liver Liver NNP cord-018225-dozmy3lb 33 16 Unit Unit NNP cord-018225-dozmy3lb 33 17 , , , cord-018225-dozmy3lb 33 18 investigates investigate VBZ cord-018225-dozmy3lb 33 19 the the DT cord-018225-dozmy3lb 33 20 effects effect NNS cord-018225-dozmy3lb 33 21 of of IN cord-018225-dozmy3lb 33 22 n n NN cord-018225-dozmy3lb 33 23 - - HYPH cord-018225-dozmy3lb 33 24 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 33 25 in in IN cord-018225-dozmy3lb 33 26 patients patient NNS cord-018225-dozmy3lb 33 27 with with IN cord-018225-dozmy3lb 33 28 acute acute JJ cord-018225-dozmy3lb 33 29 liver liver NN cord-018225-dozmy3lb 33 30 failure failure NN cord-018225-dozmy3lb 33 31 , , , cord-018225-dozmy3lb 33 32 and and CC cord-018225-dozmy3lb 33 33 the the DT cord-018225-dozmy3lb 33 34 findings finding NNS cord-018225-dozmy3lb 33 35 of of IN cord-018225-dozmy3lb 33 36 this this DT cord-018225-dozmy3lb 33 37 study study NN cord-018225-dozmy3lb 33 38 have have VBP cord-018225-dozmy3lb 33 39 resulted result VBN cord-018225-dozmy3lb 33 40 in in IN cord-018225-dozmy3lb 33 41 widespread widespread JJ cord-018225-dozmy3lb 33 42 use use NN cord-018225-dozmy3lb 33 43 of of IN cord-018225-dozmy3lb 33 44 this this DT cord-018225-dozmy3lb 33 45 agent agent NN cord-018225-dozmy3lb 33 46 in in IN cord-018225-dozmy3lb 33 47 this this DT cord-018225-dozmy3lb 33 48 setting setting NN cord-018225-dozmy3lb 33 49 . . . cord-018225-dozmy3lb 34 1 Currently currently RB cord-018225-dozmy3lb 34 2 , , , cord-018225-dozmy3lb 34 3 there there EX cord-018225-dozmy3lb 34 4 is be VBZ cord-018225-dozmy3lb 34 5 still still RB cord-018225-dozmy3lb 34 6 no no DT cord-018225-dozmy3lb 34 7 safe safe JJ cord-018225-dozmy3lb 34 8 , , , cord-018225-dozmy3lb 34 9 effective effective JJ cord-018225-dozmy3lb 34 10 means mean NNS cord-018225-dozmy3lb 34 11 of of IN cord-018225-dozmy3lb 34 12 artificial artificial JJ cord-018225-dozmy3lb 34 13 liver liver NN cord-018225-dozmy3lb 34 14 support support NN cord-018225-dozmy3lb 34 15 for for IN cord-018225-dozmy3lb 34 16 patients patient NNS cord-018225-dozmy3lb 34 17 awaiting await VBG cord-018225-dozmy3lb 34 18 transplantation transplantation NN cord-018225-dozmy3lb 34 19 or or CC cord-018225-dozmy3lb 34 20 liver liver NN cord-018225-dozmy3lb 34 21 regeneration regeneration NN cord-018225-dozmy3lb 34 22 . . . cord-018225-dozmy3lb 35 1 The the DT cord-018225-dozmy3lb 35 2 case case NN cord-018225-dozmy3lb 35 3 report report NN cord-018225-dozmy3lb 35 4 from from IN cord-018225-dozmy3lb 35 5 Saunders Saunders NNP cord-018225-dozmy3lb 35 6 and and CC cord-018225-dozmy3lb 35 7 co co NNS cord-018225-dozmy3lb 35 8 - - NNS cord-018225-dozmy3lb 35 9 workers worker NNS cord-018225-dozmy3lb 35 10 from from IN cord-018225-dozmy3lb 35 11 Cape Cape NNP cord-018225-dozmy3lb 35 12 Town Town NNP cord-018225-dozmy3lb 35 13 , , , cord-018225-dozmy3lb 35 14 South South NNP cord-018225-dozmy3lb 35 15 Africa Africa NNP cord-018225-dozmy3lb 35 16 , , , cord-018225-dozmy3lb 35 17 describes describe VBZ cord-018225-dozmy3lb 35 18 an an DT cord-018225-dozmy3lb 35 19 early early JJ cord-018225-dozmy3lb 35 20 attempt attempt NN cord-018225-dozmy3lb 35 21 to to TO cord-018225-dozmy3lb 35 22 develop develop VB cord-018225-dozmy3lb 35 23 such such JJ cord-018225-dozmy3lb 35 24 support support NN cord-018225-dozmy3lb 35 25 . . . cord-018225-dozmy3lb 36 1 Finally finally RB cord-018225-dozmy3lb 36 2 , , , cord-018225-dozmy3lb 36 3 patients patient NNS cord-018225-dozmy3lb 36 4 with with IN cord-018225-dozmy3lb 36 5 cirrhosis cirrhosis NN cord-018225-dozmy3lb 36 6 and and CC cord-018225-dozmy3lb 36 7 other other JJ cord-018225-dozmy3lb 36 8 forms form NNS cord-018225-dozmy3lb 36 9 of of IN cord-018225-dozmy3lb 36 10 chronic chronic JJ cord-018225-dozmy3lb 36 11 liver liver NN cord-018225-dozmy3lb 36 12 disease disease NN cord-018225-dozmy3lb 36 13 present present VBP cord-018225-dozmy3lb 36 14 different different JJ cord-018225-dozmy3lb 36 15 management management NN cord-018225-dozmy3lb 36 16 challenges challenge NNS cord-018225-dozmy3lb 36 17 for for IN cord-018225-dozmy3lb 36 18 the the DT cord-018225-dozmy3lb 36 19 intensive intensive JJ cord-018225-dozmy3lb 36 20 care care NN cord-018225-dozmy3lb 36 21 specialist specialist NN cord-018225-dozmy3lb 36 22 . . . cord-018225-dozmy3lb 37 1 The the DT cord-018225-dozmy3lb 37 2 randomized randomized JJ cord-018225-dozmy3lb 37 3 controlled control VBN cord-018225-dozmy3lb 37 4 trial trial NN cord-018225-dozmy3lb 37 5 from from IN cord-018225-dozmy3lb 37 6 the the DT cord-018225-dozmy3lb 37 7 Barcelona Barcelona NNP cord-018225-dozmy3lb 37 8 group group NN cord-018225-dozmy3lb 37 9 shows show VBZ cord-018225-dozmy3lb 37 10 that that IN cord-018225-dozmy3lb 37 11 in in IN cord-018225-dozmy3lb 37 12 patients patient NNS cord-018225-dozmy3lb 37 13 with with IN cord-018225-dozmy3lb 37 14 spontaneous spontaneous JJ cord-018225-dozmy3lb 37 15 bacterial bacterial JJ cord-018225-dozmy3lb 37 16 peritonitis peritonitis NN cord-018225-dozmy3lb 37 17 and and CC cord-018225-dozmy3lb 37 18 cirrhosis cirrhosis NN cord-018225-dozmy3lb 37 19 , , , cord-018225-dozmy3lb 37 20 the the DT cord-018225-dozmy3lb 37 21 outcome outcome NN cord-018225-dozmy3lb 37 22 is be VBZ cord-018225-dozmy3lb 37 23 improved improve VBN cord-018225-dozmy3lb 37 24 by by IN cord-018225-dozmy3lb 37 25 infusing infuse VBG cord-018225-dozmy3lb 37 26 albumin albumin NN cord-018225-dozmy3lb 37 27 in in IN cord-018225-dozmy3lb 37 28 addition addition NN cord-018225-dozmy3lb 37 29 to to IN cord-018225-dozmy3lb 37 30 antibiotic antibiotic JJ cord-018225-dozmy3lb 37 31 therapy therapy NN cord-018225-dozmy3lb 37 32 . . . cord-018225-dozmy3lb 38 1 There there EX cord-018225-dozmy3lb 38 2 are be VBP cord-018225-dozmy3lb 38 3 many many JJ cord-018225-dozmy3lb 38 4 classic classic JJ cord-018225-dozmy3lb 38 5 papers paper NNS cord-018225-dozmy3lb 38 6 that that WDT cord-018225-dozmy3lb 38 7 have have VBP cord-018225-dozmy3lb 38 8 not not RB cord-018225-dozmy3lb 38 9 been be VBN cord-018225-dozmy3lb 38 10 included include VBN cord-018225-dozmy3lb 38 11 in in IN cord-018225-dozmy3lb 38 12 this this DT cord-018225-dozmy3lb 38 13 small small JJ cord-018225-dozmy3lb 38 14 selection selection NN cord-018225-dozmy3lb 38 15 . . . cord-018225-dozmy3lb 39 1 The the DT cord-018225-dozmy3lb 39 2 majority majority NN cord-018225-dozmy3lb 39 3 of of IN cord-018225-dozmy3lb 39 4 papers paper NNS cord-018225-dozmy3lb 39 5 have have VBP cord-018225-dozmy3lb 39 6 been be VBN cord-018225-dozmy3lb 39 7 chosen choose VBN cord-018225-dozmy3lb 39 8 for for IN cord-018225-dozmy3lb 39 9 the the DT cord-018225-dozmy3lb 39 10 underlying underlie VBG cord-018225-dozmy3lb 39 11 ideas idea NNS cord-018225-dozmy3lb 39 12 and and CC cord-018225-dozmy3lb 39 13 variety variety NN cord-018225-dozmy3lb 39 14 rather rather RB cord-018225-dozmy3lb 39 15 than than IN cord-018225-dozmy3lb 39 16 for for IN cord-018225-dozmy3lb 39 17 scientific scientific JJ cord-018225-dozmy3lb 39 18 rigor rigor NN cord-018225-dozmy3lb 39 19 . . . cord-018225-dozmy3lb 40 1 They -PRON- PRP cord-018225-dozmy3lb 40 2 are be VBP cord-018225-dozmy3lb 40 3 aimed aim VBN cord-018225-dozmy3lb 40 4 at at IN cord-018225-dozmy3lb 40 5 clinical clinical JJ cord-018225-dozmy3lb 40 6 intensive intensive JJ cord-018225-dozmy3lb 40 7 care care NN cord-018225-dozmy3lb 40 8 specialists specialist NNS cord-018225-dozmy3lb 40 9 with with IN cord-018225-dozmy3lb 40 10 enquiring enquire VBG cord-018225-dozmy3lb 40 11 minds mind NNS cord-018225-dozmy3lb 40 12 who who WP cord-018225-dozmy3lb 40 13 work work VBP cord-018225-dozmy3lb 40 14 in in IN cord-018225-dozmy3lb 40 15 general general JJ cord-018225-dozmy3lb 40 16 intensive intensive JJ cord-018225-dozmy3lb 40 17 care care NN cord-018225-dozmy3lb 40 18 units unit NNS cord-018225-dozmy3lb 40 19 , , , cord-018225-dozmy3lb 40 20 rather rather RB cord-018225-dozmy3lb 40 21 than than IN cord-018225-dozmy3lb 40 22 experts expert NNS cord-018225-dozmy3lb 40 23 in in IN cord-018225-dozmy3lb 40 24 liver liver NN cord-018225-dozmy3lb 40 25 units unit NNS cord-018225-dozmy3lb 40 26 or or CC cord-018225-dozmy3lb 40 27 intensive intensive JJ cord-018225-dozmy3lb 40 28 care care NN cord-018225-dozmy3lb 40 29 units unit NNS cord-018225-dozmy3lb 40 30 servicing service VBG cord-018225-dozmy3lb 40 31 liver liver NN cord-018225-dozmy3lb 40 32 transplant transplant NN cord-018225-dozmy3lb 40 33 units unit NNS cord-018225-dozmy3lb 40 34 . . . cord-018225-dozmy3lb 41 1 I -PRON- PRP cord-018225-dozmy3lb 41 2 have have VBP cord-018225-dozmy3lb 41 3 found find VBN cord-018225-dozmy3lb 41 4 the the DT cord-018225-dozmy3lb 41 5 liver liver NN cord-018225-dozmy3lb 41 6 a a DT cord-018225-dozmy3lb 41 7 fascinating fascinating JJ cord-018225-dozmy3lb 41 8 organ organ NN cord-018225-dozmy3lb 41 9 to to TO cord-018225-dozmy3lb 41 10 study study VB cord-018225-dozmy3lb 41 11 . . . cord-018225-dozmy3lb 42 1 I -PRON- PRP cord-018225-dozmy3lb 42 2 trust trust VBP cord-018225-dozmy3lb 42 3 this this DT cord-018225-dozmy3lb 42 4 selection selection NN cord-018225-dozmy3lb 42 5 of of IN cord-018225-dozmy3lb 42 6 papers paper NNS cord-018225-dozmy3lb 42 7 will will MD cord-018225-dozmy3lb 42 8 likewise likewise RB cord-018225-dozmy3lb 42 9 stimulate stimulate VB cord-018225-dozmy3lb 42 10 your -PRON- PRP$ cord-018225-dozmy3lb 42 11 interest interest NN cord-018225-dozmy3lb 42 12 . . . cord-018225-dozmy3lb 42 13 _SP cord-018225-dozmy3lb 43 1 Hippocrates Hippocrates NNP cord-018225-dozmy3lb 43 2 examines examine VBZ cord-018225-dozmy3lb 43 3 a a DT cord-018225-dozmy3lb 43 4 number number NN cord-018225-dozmy3lb 43 5 of of IN cord-018225-dozmy3lb 43 6 questions question NNS cord-018225-dozmy3lb 43 7 with with IN cord-018225-dozmy3lb 43 8 respect respect NN cord-018225-dozmy3lb 43 9 to to IN cord-018225-dozmy3lb 43 10 jaundice jaundice NN cord-018225-dozmy3lb 43 11 associated associate VBN cord-018225-dozmy3lb 43 12 with with IN cord-018225-dozmy3lb 43 13 systemic systemic JJ cord-018225-dozmy3lb 43 14 infection infection NN cord-018225-dozmy3lb 43 15 . . . cord-018225-dozmy3lb 44 1 He -PRON- PRP cord-018225-dozmy3lb 44 2 concludes conclude VBZ cord-018225-dozmy3lb 44 3 that that IN cord-018225-dozmy3lb 44 4 jaundice jaundice NN cord-018225-dozmy3lb 44 5 is be VBZ cord-018225-dozmy3lb 44 6 a a DT cord-018225-dozmy3lb 44 7 result result NN cord-018225-dozmy3lb 44 8 of of IN cord-018225-dozmy3lb 44 9 impairment impairment NN cord-018225-dozmy3lb 44 10 of of IN cord-018225-dozmy3lb 44 11 the the DT cord-018225-dozmy3lb 44 12 separative separative JJ cord-018225-dozmy3lb 44 13 faculty faculty NN cord-018225-dozmy3lb 44 14 of of IN cord-018225-dozmy3lb 44 15 the the DT cord-018225-dozmy3lb 44 16 liver liver NN cord-018225-dozmy3lb 44 17 ; ; : cord-018225-dozmy3lb 44 18 that that RB cord-018225-dozmy3lb 44 19 is is RB cord-018225-dozmy3lb 44 20 , , , cord-018225-dozmy3lb 44 21 impairment impairment NN cord-018225-dozmy3lb 44 22 of of IN cord-018225-dozmy3lb 44 23 its -PRON- PRP$ cord-018225-dozmy3lb 44 24 ability ability NN cord-018225-dozmy3lb 44 25 to to TO cord-018225-dozmy3lb 44 26 purify purify VB cord-018225-dozmy3lb 44 27 all all PDT cord-018225-dozmy3lb 44 28 the the DT cord-018225-dozmy3lb 44 29 humors humor NNS cord-018225-dozmy3lb 44 30 . . . cord-018225-dozmy3lb 45 1 He -PRON- PRP cord-018225-dozmy3lb 45 2 further further RB cord-018225-dozmy3lb 45 3 states state VBZ cord-018225-dozmy3lb 45 4 that that IN cord-018225-dozmy3lb 45 5 this this DT cord-018225-dozmy3lb 45 6 may may MD cord-018225-dozmy3lb 45 7 occur occur VB cord-018225-dozmy3lb 45 8 as as IN cord-018225-dozmy3lb 45 9 a a DT cord-018225-dozmy3lb 45 10 result result NN cord-018225-dozmy3lb 45 11 of of IN cord-018225-dozmy3lb 45 12 obstruction obstruction NN cord-018225-dozmy3lb 45 13 of of IN cord-018225-dozmy3lb 45 14 the the DT cord-018225-dozmy3lb 45 15 biliary biliary JJ cord-018225-dozmy3lb 45 16 vessels vessel NNS cord-018225-dozmy3lb 45 17 or or CC cord-018225-dozmy3lb 45 18 of of IN cord-018225-dozmy3lb 45 19 seething seethe VBG cord-018225-dozmy3lb 45 20 inflammations inflammation NNS cord-018225-dozmy3lb 45 21 , , , cord-018225-dozmy3lb 45 22 in in IN cord-018225-dozmy3lb 45 23 which which WDT cord-018225-dozmy3lb 45 24 case case NN cord-018225-dozmy3lb 45 25 the the DT cord-018225-dozmy3lb 45 26 blood blood NN cord-018225-dozmy3lb 45 27 is be VBZ cord-018225-dozmy3lb 45 28 distributed distribute VBN cord-018225-dozmy3lb 45 29 through through IN cord-018225-dozmy3lb 45 30 the the DT cord-018225-dozmy3lb 45 31 whole whole JJ cord-018225-dozmy3lb 45 32 body body NN cord-018225-dozmy3lb 45 33 with with IN cord-018225-dozmy3lb 45 34 a a DT cord-018225-dozmy3lb 45 35 strong strong JJ cord-018225-dozmy3lb 45 36 admixture admixture NN cord-018225-dozmy3lb 45 37 of of IN cord-018225-dozmy3lb 45 38 bile bile NN cord-018225-dozmy3lb 45 39 . . . cord-018225-dozmy3lb 45 40 _SP cord-018225-dozmy3lb 46 1 This this DT cord-018225-dozmy3lb 46 2 review review NN cord-018225-dozmy3lb 46 3 article article NN cord-018225-dozmy3lb 46 4 explores explore VBZ cord-018225-dozmy3lb 46 5 the the DT cord-018225-dozmy3lb 46 6 role role NN cord-018225-dozmy3lb 46 7 of of IN cord-018225-dozmy3lb 46 8 the the DT cord-018225-dozmy3lb 46 9 liver liver NN cord-018225-dozmy3lb 46 10 in in IN cord-018225-dozmy3lb 46 11 the the DT cord-018225-dozmy3lb 46 12 pathogenesis pathogenesis NN cord-018225-dozmy3lb 46 13 of of IN cord-018225-dozmy3lb 46 14 the the DT cord-018225-dozmy3lb 46 15 adult adult NN cord-018225-dozmy3lb 46 16 respiratory respiratory JJ cord-018225-dozmy3lb 46 17 distress distress NN cord-018225-dozmy3lb 46 18 syndrome syndrome NN cord-018225-dozmy3lb 46 19 ( ( -LRB- cord-018225-dozmy3lb 46 20 ARDS ARDS NNP cord-018225-dozmy3lb 46 21 ) ) -RRB- cord-018225-dozmy3lb 46 22 and and CC cord-018225-dozmy3lb 46 23 progressive progressive JJ cord-018225-dozmy3lb 46 24 multiple multiple JJ cord-018225-dozmy3lb 46 25 systems system NNS cord-018225-dozmy3lb 46 26 organ organ NN cord-018225-dozmy3lb 46 27 failure failure NN cord-018225-dozmy3lb 46 28 . . . cord-018225-dozmy3lb 47 1 It -PRON- PRP cord-018225-dozmy3lb 47 2 is be VBZ cord-018225-dozmy3lb 47 3 argued argue VBN cord-018225-dozmy3lb 47 4 that that IN cord-018225-dozmy3lb 47 5 the the DT cord-018225-dozmy3lb 47 6 normal normal JJ cord-018225-dozmy3lb 47 7 liver liver NN cord-018225-dozmy3lb 47 8 plays play VBZ cord-018225-dozmy3lb 47 9 a a DT cord-018225-dozmy3lb 47 10 pivotal pivotal JJ cord-018225-dozmy3lb 47 11 role role NN cord-018225-dozmy3lb 47 12 in in IN cord-018225-dozmy3lb 47 13 aspects aspect NNS cord-018225-dozmy3lb 47 14 of of IN cord-018225-dozmy3lb 47 15 host host NN cord-018225-dozmy3lb 47 16 defence defence NN cord-018225-dozmy3lb 47 17 that that WDT cord-018225-dozmy3lb 47 18 are be VBP cord-018225-dozmy3lb 47 19 crucial crucial JJ cord-018225-dozmy3lb 47 20 to to IN cord-018225-dozmy3lb 47 21 the the DT cord-018225-dozmy3lb 47 22 protection protection NN cord-018225-dozmy3lb 47 23 of of IN cord-018225-dozmy3lb 47 24 the the DT cord-018225-dozmy3lb 47 25 lung lung NN cord-018225-dozmy3lb 47 26 and and CC cord-018225-dozmy3lb 47 27 other other JJ cord-018225-dozmy3lb 47 28 organs organ NNS cord-018225-dozmy3lb 47 29 in in IN cord-018225-dozmy3lb 47 30 systemic systemic JJ cord-018225-dozmy3lb 47 31 sepsis sepsis NN cord-018225-dozmy3lb 47 32 . . . cord-018225-dozmy3lb 48 1 The the DT cord-018225-dozmy3lb 48 2 authors author NNS cord-018225-dozmy3lb 48 3 note note VBP cord-018225-dozmy3lb 48 4 that that IN cord-018225-dozmy3lb 48 5 the the DT cord-018225-dozmy3lb 48 6 fixed fix VBN cord-018225-dozmy3lb 48 7 hepatic hepatic JJ cord-018225-dozmy3lb 48 8 macrophages macrophage NNS cord-018225-dozmy3lb 48 9 , , , cord-018225-dozmy3lb 48 10 or or CC cord-018225-dozmy3lb 48 11 Kupffer Kupffer NNP cord-018225-dozmy3lb 48 12 cells cell NNS cord-018225-dozmy3lb 48 13 , , , cord-018225-dozmy3lb 48 14 constitute constitute VBP cord-018225-dozmy3lb 48 15 nearly nearly RB cord-018225-dozmy3lb 48 16 90 90 CD cord-018225-dozmy3lb 48 17 % % NN cord-018225-dozmy3lb 48 18 of of IN cord-018225-dozmy3lb 48 19 the the DT cord-018225-dozmy3lb 48 20 body body NN cord-018225-dozmy3lb 48 21 's 's POS cord-018225-dozmy3lb 48 22 reticuloendothelial reticuloendothelial JJ cord-018225-dozmy3lb 48 23 cell cell NN cord-018225-dozmy3lb 48 24 mass mass NN cord-018225-dozmy3lb 48 25 . . . cord-018225-dozmy3lb 49 1 They -PRON- PRP cord-018225-dozmy3lb 49 2 further further RB cord-018225-dozmy3lb 49 3 note note VBP cord-018225-dozmy3lb 49 4 that that IN cord-018225-dozmy3lb 49 5 these these DT cord-018225-dozmy3lb 49 6 cells cell NNS cord-018225-dozmy3lb 49 7 are be VBP cord-018225-dozmy3lb 49 8 the the DT cord-018225-dozmy3lb 49 9 major major JJ cord-018225-dozmy3lb 49 10 mechanism mechanism NN cord-018225-dozmy3lb 49 11 for for IN cord-018225-dozmy3lb 49 12 clearance clearance NN cord-018225-dozmy3lb 49 13 of of IN cord-018225-dozmy3lb 49 14 systemic systemic JJ cord-018225-dozmy3lb 49 15 endotoxin endotoxin NN cord-018225-dozmy3lb 49 16 and and CC cord-018225-dozmy3lb 49 17 bacterial bacterial JJ cord-018225-dozmy3lb 49 18 products product NNS cord-018225-dozmy3lb 49 19 . . . cord-018225-dozmy3lb 50 1 The the DT cord-018225-dozmy3lb 50 2 strategic strategic JJ cord-018225-dozmy3lb 50 3 location location NN cord-018225-dozmy3lb 50 4 of of IN cord-018225-dozmy3lb 50 5 the the DT cord-018225-dozmy3lb 50 6 liver liver NN cord-018225-dozmy3lb 50 7 , , , cord-018225-dozmy3lb 50 8 immediately immediately RB cord-018225-dozmy3lb 50 9 downstream downstream RB cord-018225-dozmy3lb 50 10 from from IN cord-018225-dozmy3lb 50 11 the the DT cord-018225-dozmy3lb 50 12 large large JJ cord-018225-dozmy3lb 50 13 gastrointestinal gastrointestinal JJ cord-018225-dozmy3lb 50 14 reservoir reservoir NN cord-018225-dozmy3lb 50 15 of of IN cord-018225-dozmy3lb 50 16 bacteria bacteria NNS cord-018225-dozmy3lb 50 17 and and CC cord-018225-dozmy3lb 50 18 bacterial bacterial JJ cord-018225-dozmy3lb 50 19 products product NNS cord-018225-dozmy3lb 50 20 , , , cord-018225-dozmy3lb 50 21 normally normally RB cord-018225-dozmy3lb 50 22 constitutes constitute VBZ cord-018225-dozmy3lb 50 23 an an DT cord-018225-dozmy3lb 50 24 effective effective JJ cord-018225-dozmy3lb 50 25 first first JJ cord-018225-dozmy3lb 50 26 line line NN cord-018225-dozmy3lb 50 27 in in IN cord-018225-dozmy3lb 50 28 host host NN cord-018225-dozmy3lb 50 29 control control NN cord-018225-dozmy3lb 50 30 of of IN cord-018225-dozmy3lb 50 31 systemic systemic JJ cord-018225-dozmy3lb 50 32 endotoxemia endotoxemia NN cord-018225-dozmy3lb 50 33 and and CC cord-018225-dozmy3lb 50 34 bacteremia bacteremia NN cord-018225-dozmy3lb 50 35 . . . cord-018225-dozmy3lb 51 1 However however RB cord-018225-dozmy3lb 51 2 , , , cord-018225-dozmy3lb 51 3 the the DT cord-018225-dozmy3lb 51 4 balance balance NN cord-018225-dozmy3lb 51 5 may may MD cord-018225-dozmy3lb 51 6 be be VB cord-018225-dozmy3lb 51 7 altered alter VBN cord-018225-dozmy3lb 51 8 by by IN cord-018225-dozmy3lb 51 9 an an DT cord-018225-dozmy3lb 51 10 excess excess JJ cord-018225-dozmy3lb 51 11 load load NN cord-018225-dozmy3lb 51 12 of of IN cord-018225-dozmy3lb 51 13 bacterial bacterial JJ cord-018225-dozmy3lb 51 14 products product NNS cord-018225-dozmy3lb 51 15 in in IN cord-018225-dozmy3lb 51 16 the the DT cord-018225-dozmy3lb 51 17 gut gut NN cord-018225-dozmy3lb 51 18 , , , cord-018225-dozmy3lb 51 19 mesenteric mesenteric JJ cord-018225-dozmy3lb 51 20 or or CC cord-018225-dozmy3lb 51 21 hepatic hepatic JJ cord-018225-dozmy3lb 51 22 ischemia ischemia NN cord-018225-dozmy3lb 51 23 , , , cord-018225-dozmy3lb 51 24 and and CC cord-018225-dozmy3lb 51 25 Kupffer Kupffer NNP cord-018225-dozmy3lb 51 26 cell cell NN cord-018225-dozmy3lb 51 27 dysfunction dysfunction NN cord-018225-dozmy3lb 51 28 , , , cord-018225-dozmy3lb 51 29 so so IN cord-018225-dozmy3lb 51 30 that that IN cord-018225-dozmy3lb 51 31 the the DT cord-018225-dozmy3lb 51 32 phagocytic phagocytic JJ cord-018225-dozmy3lb 51 33 capacity capacity NN cord-018225-dozmy3lb 51 34 of of IN cord-018225-dozmy3lb 51 35 Kupffer Kupffer NNP cord-018225-dozmy3lb 51 36 cells cell NNS cord-018225-dozmy3lb 51 37 is be VBZ cord-018225-dozmy3lb 51 38 exceeded exceed VBN cord-018225-dozmy3lb 51 39 , , , cord-018225-dozmy3lb 51 40 resulting result VBG cord-018225-dozmy3lb 51 41 in in IN cord-018225-dozmy3lb 51 42 systemic systemic JJ cord-018225-dozmy3lb 51 43 spread spread NN cord-018225-dozmy3lb 51 44 of of IN cord-018225-dozmy3lb 51 45 bacterial bacterial JJ cord-018225-dozmy3lb 51 46 products product NNS cord-018225-dozmy3lb 51 47 . . . cord-018225-dozmy3lb 52 1 Moreover moreover RB cord-018225-dozmy3lb 52 2 , , , cord-018225-dozmy3lb 52 3 the the DT cord-018225-dozmy3lb 52 4 authors author NNS cord-018225-dozmy3lb 52 5 describe describe VBP cord-018225-dozmy3lb 52 6 the the DT cord-018225-dozmy3lb 52 7 activation activation NN cord-018225-dozmy3lb 52 8 of of IN cord-018225-dozmy3lb 52 9 Kupffer Kupffer NNP cord-018225-dozmy3lb 52 10 cells cell NNS cord-018225-dozmy3lb 52 11 by by IN cord-018225-dozmy3lb 52 12 the the DT cord-018225-dozmy3lb 52 13 phagocytic phagocytic JJ cord-018225-dozmy3lb 52 14 burst burst NN cord-018225-dozmy3lb 52 15 , , , cord-018225-dozmy3lb 52 16 resulting result VBG cord-018225-dozmy3lb 52 17 in in IN cord-018225-dozmy3lb 52 18 the the DT cord-018225-dozmy3lb 52 19 release release NN cord-018225-dozmy3lb 52 20 of of IN cord-018225-dozmy3lb 52 21 an an DT cord-018225-dozmy3lb 52 22 array array NN cord-018225-dozmy3lb 52 23 of of IN cord-018225-dozmy3lb 52 24 inflammatory inflammatory JJ cord-018225-dozmy3lb 52 25 mediators mediator NNS cord-018225-dozmy3lb 52 26 that that WDT cord-018225-dozmy3lb 52 27 are be VBP cord-018225-dozmy3lb 52 28 ' ' `` cord-018225-dozmy3lb 52 29 exported export VBN cord-018225-dozmy3lb 52 30 ' ' '' cord-018225-dozmy3lb 52 31 systemically systemically RB cord-018225-dozmy3lb 52 32 , , , cord-018225-dozmy3lb 52 33 and and CC cord-018225-dozmy3lb 52 34 result result VB cord-018225-dozmy3lb 52 35 in in IN cord-018225-dozmy3lb 52 36 acute acute JJ cord-018225-dozmy3lb 52 37 pathophysiological pathophysiological JJ cord-018225-dozmy3lb 52 38 reactions reaction NNS cord-018225-dozmy3lb 52 39 in in IN cord-018225-dozmy3lb 52 40 distant distant JJ cord-018225-dozmy3lb 52 41 organs organ NNS cord-018225-dozmy3lb 52 42 . . . cord-018225-dozmy3lb 53 1 These these DT cord-018225-dozmy3lb 53 2 inflammatory inflammatory JJ cord-018225-dozmy3lb 53 3 mediators mediator NNS cord-018225-dozmy3lb 53 4 also also RB cord-018225-dozmy3lb 53 5 have have VBP cord-018225-dozmy3lb 53 6 effects effect NNS cord-018225-dozmy3lb 53 7 on on IN cord-018225-dozmy3lb 53 8 adjoining adjoin VBG cord-018225-dozmy3lb 53 9 hepatic hepatic JJ cord-018225-dozmy3lb 53 10 parenchymal parenchymal NN cord-018225-dozmy3lb 53 11 cells cell NNS cord-018225-dozmy3lb 53 12 . . . cord-018225-dozmy3lb 54 1 Evidence evidence NN cord-018225-dozmy3lb 54 2 is be VBZ cord-018225-dozmy3lb 54 3 presented present VBN cord-018225-dozmy3lb 54 4 that that IN cord-018225-dozmy3lb 54 5 the the DT cord-018225-dozmy3lb 54 6 resulting result VBG cord-018225-dozmy3lb 54 7 hepatocyte hepatocyte NN cord-018225-dozmy3lb 54 8 damage damage NN cord-018225-dozmy3lb 54 9 may may MD cord-018225-dozmy3lb 54 10 result result VB cord-018225-dozmy3lb 54 11 in in IN cord-018225-dozmy3lb 54 12 decreased decreased JJ cord-018225-dozmy3lb 54 13 clearance clearance NN cord-018225-dozmy3lb 54 14 of of IN cord-018225-dozmy3lb 54 15 some some DT cord-018225-dozmy3lb 54 16 of of IN cord-018225-dozmy3lb 54 17 these these DT cord-018225-dozmy3lb 54 18 mediators mediator NNS cord-018225-dozmy3lb 54 19 , , , cord-018225-dozmy3lb 54 20 resulting result VBG cord-018225-dozmy3lb 54 21 in in IN cord-018225-dozmy3lb 54 22 heightened heightened JJ cord-018225-dozmy3lb 54 23 and and CC cord-018225-dozmy3lb 54 24 prolonged prolong VBN cord-018225-dozmy3lb 54 25 effects effect NNS cord-018225-dozmy3lb 54 26 , , , cord-018225-dozmy3lb 54 27 and and CC cord-018225-dozmy3lb 54 28 consequent consequent JJ cord-018225-dozmy3lb 54 29 amplification amplification NN cord-018225-dozmy3lb 54 30 of of IN cord-018225-dozmy3lb 54 31 multiple multiple JJ cord-018225-dozmy3lb 54 32 organ organ NN cord-018225-dozmy3lb 54 33 damage damage NN cord-018225-dozmy3lb 54 34 . . . cord-018225-dozmy3lb 55 1 Furthermore furthermore RB cord-018225-dozmy3lb 55 2 , , , cord-018225-dozmy3lb 55 3 these these DT cord-018225-dozmy3lb 55 4 inflammatory inflammatory JJ cord-018225-dozmy3lb 55 5 mediators mediator NNS cord-018225-dozmy3lb 55 6 -particularly -particularly RB cord-018225-dozmy3lb 56 1 interleukin-1 interleukin-1 NN cord-018225-dozmy3lb 56 2 -induce -induce NN cord-018225-dozmy3lb 56 3 changes change NNS cord-018225-dozmy3lb 56 4 in in IN cord-018225-dozmy3lb 56 5 hepatic hepatic JJ cord-018225-dozmy3lb 56 6 protein protein NN cord-018225-dozmy3lb 56 7 synthesis synthesis NN cord-018225-dozmy3lb 56 8 , , , cord-018225-dozmy3lb 56 9 characterized characterize VBN cord-018225-dozmy3lb 56 10 principally principally RB cord-018225-dozmy3lb 56 11 by by IN cord-018225-dozmy3lb 56 12 the the DT cord-018225-dozmy3lb 56 13 ' ' `` cord-018225-dozmy3lb 56 14 acute acute JJ cord-018225-dozmy3lb 56 15 phase phase NN cord-018225-dozmy3lb 56 16 response response NN cord-018225-dozmy3lb 56 17 ' ' '' cord-018225-dozmy3lb 56 18 . . . cord-018225-dozmy3lb 57 1 Thus thus RB cord-018225-dozmy3lb 57 2 , , , cord-018225-dozmy3lb 57 3 this this DT cord-018225-dozmy3lb 57 4 review review NN cord-018225-dozmy3lb 57 5 acknowledges acknowledge VBZ cord-018225-dozmy3lb 57 6 the the DT cord-018225-dozmy3lb 57 7 role role NN cord-018225-dozmy3lb 57 8 of of IN cord-018225-dozmy3lb 57 9 the the DT cord-018225-dozmy3lb 57 10 liver liver NN cord-018225-dozmy3lb 57 11 in in IN cord-018225-dozmy3lb 57 12 host host NN cord-018225-dozmy3lb 57 13 defence defence NN cord-018225-dozmy3lb 57 14 but but CC cord-018225-dozmy3lb 57 15 also also RB cord-018225-dozmy3lb 57 16 proposes propose VBZ cord-018225-dozmy3lb 57 17 ways way NNS cord-018225-dozmy3lb 57 18 in in IN cord-018225-dozmy3lb 57 19 which which WDT cord-018225-dozmy3lb 57 20 liver liver NN cord-018225-dozmy3lb 57 21 dysfunction dysfunction NN cord-018225-dozmy3lb 57 22 might may MD cord-018225-dozmy3lb 57 23 fuel fuel VB cord-018225-dozmy3lb 57 24 multiple multiple JJ cord-018225-dozmy3lb 57 25 organ organ NN cord-018225-dozmy3lb 57 26 dysfunction dysfunction NN cord-018225-dozmy3lb 57 27 -particularly -particularly NNP cord-018225-dozmy3lb 57 28 ARDS ARDS NNP cord-018225-dozmy3lb 57 29 . . . cord-018225-dozmy3lb 57 30 _SP cord-018225-dozmy3lb 58 1 The the DT cord-018225-dozmy3lb 58 2 liver liver NN cord-018225-dozmy3lb 58 3 plays play VBZ cord-018225-dozmy3lb 58 4 a a DT cord-018225-dozmy3lb 58 5 major major JJ cord-018225-dozmy3lb 58 6 role role NN cord-018225-dozmy3lb 58 7 in in IN cord-018225-dozmy3lb 58 8 host host NN cord-018225-dozmy3lb 58 9 defence defence NN cord-018225-dozmy3lb 58 10 , , , cord-018225-dozmy3lb 58 11 but but CC cord-018225-dozmy3lb 58 12 also also RB cord-018225-dozmy3lb 58 13 has have VBZ cord-018225-dozmy3lb 58 14 the the DT cord-018225-dozmy3lb 58 15 capacity capacity NN cord-018225-dozmy3lb 58 16 to to TO cord-018225-dozmy3lb 58 17 augment augment VB cord-018225-dozmy3lb 58 18 the the DT cord-018225-dozmy3lb 58 19 host host NN cord-018225-dozmy3lb 58 20 response response NN cord-018225-dozmy3lb 58 21 , , , cord-018225-dozmy3lb 58 22 with with IN cord-018225-dozmy3lb 58 23 consequent consequent JJ cord-018225-dozmy3lb 58 24 adverse adverse JJ cord-018225-dozmy3lb 58 25 effects effect NNS cord-018225-dozmy3lb 58 26 on on IN cord-018225-dozmy3lb 58 27 other other JJ cord-018225-dozmy3lb 58 28 organs organ NNS cord-018225-dozmy3lb 58 29 in in IN cord-018225-dozmy3lb 58 30 some some DT cord-018225-dozmy3lb 58 31 circumstances circumstance NNS cord-018225-dozmy3lb 58 32 . . . cord-018225-dozmy3lb 59 1 This this DT cord-018225-dozmy3lb 59 2 has have VBZ cord-018225-dozmy3lb 59 3 led lead VBN cord-018225-dozmy3lb 59 4 to to IN cord-018225-dozmy3lb 59 5 the the DT cord-018225-dozmy3lb 59 6 concept concept NN cord-018225-dozmy3lb 59 7 of of IN cord-018225-dozmy3lb 59 8 the the DT cord-018225-dozmy3lb 59 9 liver liver NN cord-018225-dozmy3lb 59 10 as as IN cord-018225-dozmy3lb 59 11 ' ' '' cord-018225-dozmy3lb 59 12 the the DT cord-018225-dozmy3lb 59 13 motor motor NN cord-018225-dozmy3lb 59 14 of of IN cord-018225-dozmy3lb 59 15 multiple multiple JJ cord-018225-dozmy3lb 59 16 organ organ NN cord-018225-dozmy3lb 59 17 failure failure NN cord-018225-dozmy3lb 59 18 ' ' '' cord-018225-dozmy3lb 59 19 . . . cord-018225-dozmy3lb 60 1 This this DT cord-018225-dozmy3lb 60 2 review review NN cord-018225-dozmy3lb 60 3 was be VBD cord-018225-dozmy3lb 60 4 among among IN cord-018225-dozmy3lb 60 5 the the DT cord-018225-dozmy3lb 60 6 first first JJ cord-018225-dozmy3lb 60 7 to to TO cord-018225-dozmy3lb 60 8 provide provide VB cord-018225-dozmy3lb 60 9 a a DT cord-018225-dozmy3lb 60 10 plausible plausible JJ cord-018225-dozmy3lb 60 11 concept concept NN cord-018225-dozmy3lb 60 12 of of IN cord-018225-dozmy3lb 60 13 organ organ NN cord-018225-dozmy3lb 60 14 system system NN cord-018225-dozmy3lb 60 15 interactions interaction NNS cord-018225-dozmy3lb 60 16 that that WDT cord-018225-dozmy3lb 60 17 may may MD cord-018225-dozmy3lb 60 18 result result VB cord-018225-dozmy3lb 60 19 in in IN cord-018225-dozmy3lb 60 20 ARDS ARDS NNP cord-018225-dozmy3lb 60 21 and and CC cord-018225-dozmy3lb 60 22 multiple multiple JJ cord-018225-dozmy3lb 60 23 organ organ NN cord-018225-dozmy3lb 60 24 failure failure NN cord-018225-dozmy3lb 60 25 in in IN cord-018225-dozmy3lb 60 26 sepsis sepsis NN cord-018225-dozmy3lb 60 27 . . . cord-018225-dozmy3lb 61 1 Although although IN cord-018225-dozmy3lb 61 2 some some DT cord-018225-dozmy3lb 61 3 of of IN cord-018225-dozmy3lb 61 4 the the DT cord-018225-dozmy3lb 61 5 detail detail NN cord-018225-dozmy3lb 61 6 has have VBZ cord-018225-dozmy3lb 61 7 been be VBN cord-018225-dozmy3lb 61 8 refined refine VBN cord-018225-dozmy3lb 61 9 , , , cord-018225-dozmy3lb 61 10 the the DT cord-018225-dozmy3lb 61 11 general general JJ cord-018225-dozmy3lb 61 12 principles principle NNS cord-018225-dozmy3lb 61 13 remain remain VBP cord-018225-dozmy3lb 61 14 accepted accept VBN cord-018225-dozmy3lb 61 15 15 15 CD cord-018225-dozmy3lb 61 16 years year NNS cord-018225-dozmy3lb 61 17 later later RB cord-018225-dozmy3lb 61 18 . . . cord-018225-dozmy3lb 62 1 This this DT cord-018225-dozmy3lb 62 2 paper paper NN cord-018225-dozmy3lb 62 3 synthesizes synthesize VBZ cord-018225-dozmy3lb 62 4 experimental experimental JJ cord-018225-dozmy3lb 62 5 findings finding NNS cord-018225-dozmy3lb 62 6 from from IN cord-018225-dozmy3lb 62 7 a a DT cord-018225-dozmy3lb 62 8 number number NN cord-018225-dozmy3lb 62 9 of of IN cord-018225-dozmy3lb 62 10 disciplines discipline NNS cord-018225-dozmy3lb 62 11 -intensive -intensive : cord-018225-dozmy3lb 62 12 care care NN cord-018225-dozmy3lb 62 13 medicine medicine NN cord-018225-dozmy3lb 62 14 , , , cord-018225-dozmy3lb 62 15 hepatology hepatology NN cord-018225-dozmy3lb 62 16 , , , cord-018225-dozmy3lb 62 17 immunology immunology NN cord-018225-dozmy3lb 62 18 , , , cord-018225-dozmy3lb 62 19 and and CC cord-018225-dozmy3lb 62 20 thoracic thoracic JJ cord-018225-dozmy3lb 62 21 medicine medicine NN cord-018225-dozmy3lb 62 22 -to -to : cord-018225-dozmy3lb 62 23 arrive arrive VBP cord-018225-dozmy3lb 62 24 at at IN cord-018225-dozmy3lb 62 25 a a DT cord-018225-dozmy3lb 62 26 concept concept NN cord-018225-dozmy3lb 62 27 that that WDT cord-018225-dozmy3lb 62 28 was be VBD cord-018225-dozmy3lb 62 29 new new JJ cord-018225-dozmy3lb 62 30 at at IN cord-018225-dozmy3lb 62 31 the the DT cord-018225-dozmy3lb 62 32 time time NN cord-018225-dozmy3lb 62 33 of of IN cord-018225-dozmy3lb 62 34 publication publication NN cord-018225-dozmy3lb 62 35 , , , cord-018225-dozmy3lb 62 36 and and CC cord-018225-dozmy3lb 62 37 which which WDT cord-018225-dozmy3lb 62 38 continues continue VBZ cord-018225-dozmy3lb 62 39 to to TO cord-018225-dozmy3lb 62 40 be be VB cord-018225-dozmy3lb 62 41 supported support VBN cord-018225-dozmy3lb 62 42 in in IN cord-018225-dozmy3lb 62 43 the the DT cord-018225-dozmy3lb 62 44 main main JJ cord-018225-dozmy3lb 62 45 by by IN cord-018225-dozmy3lb 62 46 more more JJR cord-018225-dozmy3lb 62 47 recent recent JJ cord-018225-dozmy3lb 62 48 evidence evidence NN cord-018225-dozmy3lb 62 49 . . . cord-018225-dozmy3lb 63 1 This this DT cord-018225-dozmy3lb 63 2 paper paper NN cord-018225-dozmy3lb 63 3 is be VBZ cord-018225-dozmy3lb 63 4 not not RB cord-018225-dozmy3lb 63 5 a a DT cord-018225-dozmy3lb 63 6 systematic systematic JJ cord-018225-dozmy3lb 63 7 review review NN cord-018225-dozmy3lb 63 8 . . . cord-018225-dozmy3lb 64 1 The the DT cord-018225-dozmy3lb 64 2 general general JJ cord-018225-dozmy3lb 64 3 concepts concept NNS cord-018225-dozmy3lb 64 4 in in IN cord-018225-dozmy3lb 64 5 this this DT cord-018225-dozmy3lb 64 6 review review NN cord-018225-dozmy3lb 64 7 remain remain VBP cord-018225-dozmy3lb 64 8 valid valid JJ cord-018225-dozmy3lb 64 9 , , , cord-018225-dozmy3lb 64 10 and and CC cord-018225-dozmy3lb 64 11 have have VBP cord-018225-dozmy3lb 64 12 led lead VBN cord-018225-dozmy3lb 64 13 to to IN cord-018225-dozmy3lb 64 14 a a DT cord-018225-dozmy3lb 64 15 more more RBR cord-018225-dozmy3lb 64 16 concentrated concentrated JJ cord-018225-dozmy3lb 64 17 focus focus NN cord-018225-dozmy3lb 64 18 on on IN cord-018225-dozmy3lb 64 19 the the DT cord-018225-dozmy3lb 64 20 gut gut NN cord-018225-dozmy3lb 64 21 and and CC cord-018225-dozmy3lb 64 22 liver liver NN cord-018225-dozmy3lb 64 23 in in IN cord-018225-dozmy3lb 64 24 the the DT cord-018225-dozmy3lb 64 25 critically critically RB cord-018225-dozmy3lb 64 26 ill ill JJ cord-018225-dozmy3lb 64 27 patient patient NN cord-018225-dozmy3lb 64 28 , , , cord-018225-dozmy3lb 64 29 both both CC cord-018225-dozmy3lb 64 30 experimentally experimentally RB cord-018225-dozmy3lb 64 31 and and CC cord-018225-dozmy3lb 64 32 in in IN cord-018225-dozmy3lb 64 33 the the DT cord-018225-dozmy3lb 64 34 clinical clinical JJ cord-018225-dozmy3lb 64 35 setting setting NN cord-018225-dozmy3lb 64 36 . . . cord-018225-dozmy3lb 65 1 Although although IN cord-018225-dozmy3lb 65 2 there there EX cord-018225-dozmy3lb 65 3 have have VBP cord-018225-dozmy3lb 65 4 been be VBN cord-018225-dozmy3lb 65 5 major major JJ cord-018225-dozmy3lb 65 6 advances advance NNS cord-018225-dozmy3lb 65 7 in in IN cord-018225-dozmy3lb 65 8 understanding understanding NN cord-018225-dozmy3lb 65 9 of of IN cord-018225-dozmy3lb 65 10 relevant relevant JJ cord-018225-dozmy3lb 65 11 factors factor NNS cord-018225-dozmy3lb 65 12 such such JJ cord-018225-dozmy3lb 65 13 as as IN cord-018225-dozmy3lb 65 14 splanchnic splanchnic JJ cord-018225-dozmy3lb 65 15 blood blood NN cord-018225-dozmy3lb 65 16 flow flow NN cord-018225-dozmy3lb 65 17 , , , cord-018225-dozmy3lb 65 18 no no DT cord-018225-dozmy3lb 65 19 ' ' `` cord-018225-dozmy3lb 65 20 liver liver NN cord-018225-dozmy3lb 65 21 - - HYPH cord-018225-dozmy3lb 65 22 orientated orientate VBN cord-018225-dozmy3lb 65 23 therapy therapy NN cord-018225-dozmy3lb 65 24 ' ' '' cord-018225-dozmy3lb 65 25 has have VBZ cord-018225-dozmy3lb 65 26 yet yet RB cord-018225-dozmy3lb 65 27 been be VBN cord-018225-dozmy3lb 65 28 shown show VBN cord-018225-dozmy3lb 65 29 to to TO cord-018225-dozmy3lb 65 30 be be VB cord-018225-dozmy3lb 65 31 of of IN cord-018225-dozmy3lb 65 32 value value NN cord-018225-dozmy3lb 65 33 in in IN cord-018225-dozmy3lb 65 34 ARDS ARDS NNP cord-018225-dozmy3lb 65 35 and and CC cord-018225-dozmy3lb 65 36 multiple multiple JJ cord-018225-dozmy3lb 65 37 organ organ NN cord-018225-dozmy3lb 65 38 failure failure NN cord-018225-dozmy3lb 65 39 , , , cord-018225-dozmy3lb 65 40 and and CC cord-018225-dozmy3lb 65 41 the the DT cord-018225-dozmy3lb 65 42 treatment treatment NN cord-018225-dozmy3lb 65 43 of of IN cord-018225-dozmy3lb 65 44 liver liver NN cord-018225-dozmy3lb 65 45 dysfunction dysfunction NN cord-018225-dozmy3lb 65 46 remains remain VBZ cord-018225-dozmy3lb 65 47 supportive supportive JJ cord-018225-dozmy3lb 65 48 . . . cord-018225-dozmy3lb 66 1 The the DT cord-018225-dozmy3lb 66 2 " " `` cord-018225-dozmy3lb 66 3 jaundiced jaundiced JJ cord-018225-dozmy3lb 66 4 heart heart NN cord-018225-dozmy3lb 66 5 " " '' cord-018225-dozmy3lb 66 6 : : : cord-018225-dozmy3lb 66 7 a a DT cord-018225-dozmy3lb 66 8 possible possible JJ cord-018225-dozmy3lb 66 9 explanation explanation NN cord-018225-dozmy3lb 66 10 for for IN cord-018225-dozmy3lb 66 11 postoperative postoperative JJ cord-018225-dozmy3lb 66 12 shock shock NN cord-018225-dozmy3lb 66 13 in in IN cord-018225-dozmy3lb 66 14 obstructive obstructive JJ cord-018225-dozmy3lb 66 15 jaundice jaundice NN cord-018225-dozmy3lb 66 16 Abstract Abstract NNP cord-018225-dozmy3lb 66 17 Patients Patients NNP cord-018225-dozmy3lb 66 18 with with IN cord-018225-dozmy3lb 66 19 obstructive obstructive JJ cord-018225-dozmy3lb 66 20 jaundice jaundice NN cord-018225-dozmy3lb 66 21 are be VBP cord-018225-dozmy3lb 66 22 susceptible susceptible JJ cord-018225-dozmy3lb 66 23 to to IN cord-018225-dozmy3lb 66 24 postoperative postoperative JJ cord-018225-dozmy3lb 66 25 shock shock NN cord-018225-dozmy3lb 66 26 and and CC cord-018225-dozmy3lb 66 27 kidney kidney NN cord-018225-dozmy3lb 66 28 failure failure NN cord-018225-dozmy3lb 66 29 . . . cord-018225-dozmy3lb 67 1 The the DT cord-018225-dozmy3lb 67 2 cause cause NN cord-018225-dozmy3lb 67 3 of of IN cord-018225-dozmy3lb 67 4 these these DT cord-018225-dozmy3lb 67 5 potentially potentially RB cord-018225-dozmy3lb 67 6 fatal fatal JJ cord-018225-dozmy3lb 67 7 complications complication NNS cord-018225-dozmy3lb 67 8 has have VBZ cord-018225-dozmy3lb 67 9 not not RB cord-018225-dozmy3lb 67 10 been be VBN cord-018225-dozmy3lb 67 11 fully fully RB cord-018225-dozmy3lb 67 12 clarified clarify VBN cord-018225-dozmy3lb 67 13 . . . cord-018225-dozmy3lb 68 1 The the DT cord-018225-dozmy3lb 68 2 present present JJ cord-018225-dozmy3lb 68 3 study study NN cord-018225-dozmy3lb 68 4 was be VBD cord-018225-dozmy3lb 68 5 designed design VBN cord-018225-dozmy3lb 68 6 to to TO cord-018225-dozmy3lb 68 7 assess assess VB cord-018225-dozmy3lb 68 8 the the DT cord-018225-dozmy3lb 68 9 role role NN cord-018225-dozmy3lb 68 10 of of IN cord-018225-dozmy3lb 68 11 myocardial myocardial JJ cord-018225-dozmy3lb 68 12 dysfunction dysfunction NN cord-018225-dozmy3lb 68 13 in in IN cord-018225-dozmy3lb 68 14 the the DT cord-018225-dozmy3lb 68 15 hemodynamic hemodynamic JJ cord-018225-dozmy3lb 68 16 disturbance disturbance NN cord-018225-dozmy3lb 68 17 of of IN cord-018225-dozmy3lb 68 18 obstructive obstructive JJ cord-018225-dozmy3lb 68 19 jaundice jaundice NN cord-018225-dozmy3lb 68 20 . . . cord-018225-dozmy3lb 69 1 We -PRON- PRP cord-018225-dozmy3lb 69 2 studied study VBD cord-018225-dozmy3lb 69 3 the the DT cord-018225-dozmy3lb 69 4 effect effect NN cord-018225-dozmy3lb 69 5 of of IN cord-018225-dozmy3lb 69 6 isolated isolate VBN cord-018225-dozmy3lb 69 7 cholemia cholemia NN cord-018225-dozmy3lb 69 8 on on IN cord-018225-dozmy3lb 69 9 left left JJ cord-018225-dozmy3lb 69 10 ventricular ventricular JJ cord-018225-dozmy3lb 69 11 performance performance NN cord-018225-dozmy3lb 69 12 in in IN cord-018225-dozmy3lb 69 13 five five CD cord-018225-dozmy3lb 69 14 conscious conscious JJ cord-018225-dozmy3lb 69 15 dogs dog NNS cord-018225-dozmy3lb 69 16 , , , cord-018225-dozmy3lb 69 17 before before IN cord-018225-dozmy3lb 69 18 and and CC cord-018225-dozmy3lb 69 19 2 2 CD cord-018225-dozmy3lb 69 20 weeks week NNS cord-018225-dozmy3lb 69 21 after after IN cord-018225-dozmy3lb 69 22 choledochocaval choledochocaval NNP cord-018225-dozmy3lb 69 23 anastomosis anastomosis NN cord-018225-dozmy3lb 69 24 , , , cord-018225-dozmy3lb 69 25 by by IN cord-018225-dozmy3lb 69 26 using use VBG cord-018225-dozmy3lb 69 27 measurements measurement NNS cord-018225-dozmy3lb 69 28 of of IN cord-018225-dozmy3lb 69 29 systolic systolic JJ cord-018225-dozmy3lb 69 30 time time NN cord-018225-dozmy3lb 69 31 intervals interval NNS cord-018225-dozmy3lb 69 32 ( ( -LRB- cord-018225-dozmy3lb 69 33 STIs STIs NNP cord-018225-dozmy3lb 69 34 ) ) -RRB- cord-018225-dozmy3lb 69 35 and and CC cord-018225-dozmy3lb 69 36 maximal maximal JJ cord-018225-dozmy3lb 69 37 dp dp NN cord-018225-dozmy3lb 69 38 / / SYM cord-018225-dozmy3lb 69 39 dt dt NN cord-018225-dozmy3lb 69 40 . . . cord-018225-dozmy3lb 70 1 Mean mean JJ cord-018225-dozmy3lb 70 2 left leave VBN cord-018225-dozmy3lb 70 3 ventricular ventricular JJ cord-018225-dozmy3lb 70 4 ejection ejection NN cord-018225-dozmy3lb 70 5 time time NN cord-018225-dozmy3lb 70 6 ( ( -LRB- cord-018225-dozmy3lb 70 7 LVET LVET NNP cord-018225-dozmy3lb 70 8 ) ) -RRB- cord-018225-dozmy3lb 71 1 decreased decrease VBD cord-018225-dozmy3lb 71 2 after after IN cord-018225-dozmy3lb 71 3 cholemia cholemia NN cord-018225-dozmy3lb 71 4 from from IN cord-018225-dozmy3lb 71 5 159 159 CD cord-018225-dozmy3lb 71 6 + + CC cord-018225-dozmy3lb 71 7 /-2.8 /-2.8 . cord-018225-dozmy3lb 72 1 msec msec RB cord-018225-dozmy3lb 72 2 to to IN cord-018225-dozmy3lb 72 3 139 139 CD cord-018225-dozmy3lb 73 1 + + CC cord-018225-dozmy3lb 74 1 /-2.6 /-2.6 NNP cord-018225-dozmy3lb 74 2 msec msec NNP cord-018225-dozmy3lb 74 3 ( ( -LRB- cord-018225-dozmy3lb 74 4 p p NN cord-018225-dozmy3lb 74 5 < < XX cord-018225-dozmy3lb 74 6 0.005 0.005 CD cord-018225-dozmy3lb 74 7 ) ) -RRB- cord-018225-dozmy3lb 74 8 , , , cord-018225-dozmy3lb 74 9 while while IN cord-018225-dozmy3lb 74 10 mean mean JJ cord-018225-dozmy3lb 74 11 preejection preejection NN cord-018225-dozmy3lb 74 12 period period NN cord-018225-dozmy3lb 74 13 ( ( -LRB- cord-018225-dozmy3lb 74 14 PEP pep NN cord-018225-dozmy3lb 74 15 ) ) -RRB- cord-018225-dozmy3lb 74 16 and and CC cord-018225-dozmy3lb 75 1 mean mean VB cord-018225-dozmy3lb 75 2 PEP PEP NNP cord-018225-dozmy3lb 75 3 / / SYM cord-018225-dozmy3lb 75 4 LVET LVET NNP cord-018225-dozmy3lb 75 5 were be VBD cord-018225-dozmy3lb 75 6 increased increase VBN cord-018225-dozmy3lb 75 7 from from IN cord-018225-dozmy3lb 75 8 41 41 CD cord-018225-dozmy3lb 75 9 + + CC cord-018225-dozmy3lb 75 10 /-8.5 /-8.5 . cord-018225-dozmy3lb 76 1 msec msec RB cord-018225-dozmy3lb 76 2 to to IN cord-018225-dozmy3lb 76 3 87 87 CD cord-018225-dozmy3lb 77 1 + + CC cord-018225-dozmy3lb 77 2 /-14 /-14 NNP cord-018225-dozmy3lb 77 3 msec msec NNP cord-018225-dozmy3lb 77 4 ( ( -LRB- cord-018225-dozmy3lb 77 5 p p NN cord-018225-dozmy3lb 77 6 < < XX cord-018225-dozmy3lb 77 7 0.05 0.05 CD cord-018225-dozmy3lb 77 8 ) ) -RRB- cord-018225-dozmy3lb 78 1 and and CC cord-018225-dozmy3lb 78 2 from from IN cord-018225-dozmy3lb 78 3 0.39 0.39 CD cord-018225-dozmy3lb 78 4 + + CC cord-018225-dozmy3lb 78 5 /-0.06 /-0.06 . cord-018225-dozmy3lb 78 6 to to IN cord-018225-dozmy3lb 78 7 0.62 0.62 CD cord-018225-dozmy3lb 78 8 + + CD cord-018225-dozmy3lb 79 1 /-0.1 /-0.1 . cord-018225-dozmy3lb 80 1 ( ( -LRB- cord-018225-dozmy3lb 80 2 p p NN cord-018225-dozmy3lb 80 3 < < XX cord-018225-dozmy3lb 80 4 0.01 0.01 CD cord-018225-dozmy3lb 80 5 ) ) -RRB- cord-018225-dozmy3lb 80 6 , , , cord-018225-dozmy3lb 80 7 respectively respectively RB cord-018225-dozmy3lb 80 8 . . . cord-018225-dozmy3lb 81 1 During during IN cord-018225-dozmy3lb 81 2 cholemia cholemia NNP cord-018225-dozmy3lb 81 3 , , , cord-018225-dozmy3lb 81 4 STIs STIs NNP cord-018225-dozmy3lb 81 5 were be VBD cord-018225-dozmy3lb 81 6 unchanged unchanged JJ cord-018225-dozmy3lb 81 7 after after IN cord-018225-dozmy3lb 81 8 intravenous intravenous JJ cord-018225-dozmy3lb 81 9 administration administration NNP cord-018225-dozmy3lb 81 10 of of IN cord-018225-dozmy3lb 81 11 ouabain ouabain NNP cord-018225-dozmy3lb 81 12 , , , cord-018225-dozmy3lb 81 13 whereas whereas IN cord-018225-dozmy3lb 81 14 in in IN cord-018225-dozmy3lb 81 15 the the DT cord-018225-dozmy3lb 81 16 control control NN cord-018225-dozmy3lb 81 17 period period NN cord-018225-dozmy3lb 81 18 , , , cord-018225-dozmy3lb 81 19 there there EX cord-018225-dozmy3lb 81 20 was be VBD cord-018225-dozmy3lb 81 21 shortening shorten VBG cord-018225-dozmy3lb 81 22 of of IN cord-018225-dozmy3lb 81 23 mean mean JJ cord-018225-dozmy3lb 81 24 PEP pep NN cord-018225-dozmy3lb 81 25 from from IN cord-018225-dozmy3lb 81 26 71 71 CD cord-018225-dozmy3lb 81 27 + + CD cord-018225-dozmy3lb 81 28 /-8.8 /-8.8 . cord-018225-dozmy3lb 82 1 msec msec JJ cord-018225-dozmy3lb 82 2 to to IN cord-018225-dozmy3lb 82 3 58 58 CD cord-018225-dozmy3lb 83 1 + + CC cord-018225-dozmy3lb 84 1 /-7.6 /-7.6 NFP cord-018225-dozmy3lb 84 2 msec msec NNP cord-018225-dozmy3lb 84 3 ( ( -LRB- cord-018225-dozmy3lb 84 4 p p NN cord-018225-dozmy3lb 84 5 < < XX cord-018225-dozmy3lb 84 6 0.05 0.05 CD cord-018225-dozmy3lb 84 7 ) ) -RRB- cord-018225-dozmy3lb 84 8 , , , cord-018225-dozmy3lb 84 9 and and CC cord-018225-dozmy3lb 84 10 of of IN cord-018225-dozmy3lb 84 11 Q Q NNP cord-018225-dozmy3lb 84 12 - - HYPH cord-018225-dozmy3lb 84 13 S2 S2 NNP cord-018225-dozmy3lb 84 14 from from IN cord-018225-dozmy3lb 84 15 257 257 CD cord-018225-dozmy3lb 84 16 + + CC cord-018225-dozmy3lb 84 17 /-12 /-12 . cord-018225-dozmy3lb 85 1 msec msec JJ cord-018225-dozmy3lb 85 2 to to IN cord-018225-dozmy3lb 85 3 235 235 CD cord-018225-dozmy3lb 86 1 + + CC cord-018225-dozmy3lb 86 2 /-14 /-14 NNP cord-018225-dozmy3lb 86 3 msec msec NNP cord-018225-dozmy3lb 86 4 ( ( -LRB- cord-018225-dozmy3lb 86 5 p p NN cord-018225-dozmy3lb 86 6 < < XX cord-018225-dozmy3lb 86 7 0.005 0.005 CD cord-018225-dozmy3lb 86 8 ) ) -RRB- cord-018225-dozmy3lb 87 1 in in IN cord-018225-dozmy3lb 87 2 response response NN cord-018225-dozmy3lb 87 3 to to IN cord-018225-dozmy3lb 87 4 ouabain ouabain VB cord-018225-dozmy3lb 87 5 . . . cord-018225-dozmy3lb 88 1 Maximal maximal JJ cord-018225-dozmy3lb 88 2 dp dp NN cord-018225-dozmy3lb 88 3 / / SYM cord-018225-dozmy3lb 88 4 dt dt NNP cord-018225-dozmy3lb 88 5 decreased decrease VBD cord-018225-dozmy3lb 88 6 after after IN cord-018225-dozmy3lb 88 7 choledochocaval choledochocaval NNP cord-018225-dozmy3lb 88 8 anastomosis anastomosis NN cord-018225-dozmy3lb 88 9 from from IN cord-018225-dozmy3lb 88 10 4543 4543 CD cord-018225-dozmy3lb 88 11 + + CC cord-018225-dozmy3lb 89 1 /-593 /-593 : cord-018225-dozmy3lb 89 2 mmHg/ mmHg/ NNP cord-018225-dozmy3lb 89 3 sec sec NNP cord-018225-dozmy3lb 89 4 to to IN cord-018225-dozmy3lb 89 5 3666 3666 CD cord-018225-dozmy3lb 89 6 + + CC cord-018225-dozmy3lb 89 7 /-648 /-648 CD cord-018225-dozmy3lb 89 8 mmHg mmHg NNP cord-018225-dozmy3lb 89 9 / / SYM cord-018225-dozmy3lb 89 10 sec sec NNP cord-018225-dozmy3lb 90 1 ( ( -LRB- cord-018225-dozmy3lb 90 2 p p NN cord-018225-dozmy3lb 90 3 < < XX cord-018225-dozmy3lb 90 4 0.025 0.025 CD cord-018225-dozmy3lb 90 5 ) ) -RRB- cord-018225-dozmy3lb 90 6 . . . cord-018225-dozmy3lb 91 1 We -PRON- PRP cord-018225-dozmy3lb 91 2 conclude conclude VBP cord-018225-dozmy3lb 91 3 that that IN cord-018225-dozmy3lb 91 4 cholemia cholemia NN cord-018225-dozmy3lb 91 5 in in IN cord-018225-dozmy3lb 91 6 the the DT cord-018225-dozmy3lb 91 7 dog dog NN cord-018225-dozmy3lb 91 8 is be VBZ cord-018225-dozmy3lb 91 9 clearly clearly RB cord-018225-dozmy3lb 91 10 associated associate VBN cord-018225-dozmy3lb 91 11 with with IN cord-018225-dozmy3lb 91 12 impaired impaired JJ cord-018225-dozmy3lb 91 13 left left JJ cord-018225-dozmy3lb 91 14 ventricular ventricular JJ cord-018225-dozmy3lb 91 15 performance performance NN cord-018225-dozmy3lb 91 16 . . . cord-018225-dozmy3lb 92 1 The the DT cord-018225-dozmy3lb 92 2 present present JJ cord-018225-dozmy3lb 92 3 data datum NNS cord-018225-dozmy3lb 92 4 also also RB cord-018225-dozmy3lb 92 5 support support VBP cord-018225-dozmy3lb 92 6 a a DT cord-018225-dozmy3lb 92 7 previously previously RB cord-018225-dozmy3lb 92 8 published publish VBN cord-018225-dozmy3lb 92 9 in in IN cord-018225-dozmy3lb 92 10 vitro vitro FW cord-018225-dozmy3lb 92 11 study study NN cord-018225-dozmy3lb 92 12 from from IN cord-018225-dozmy3lb 92 13 our -PRON- PRP$ cord-018225-dozmy3lb 92 14 laboratory laboratory NN cord-018225-dozmy3lb 92 15 showing show VBG cord-018225-dozmy3lb 92 16 that that IN cord-018225-dozmy3lb 92 17 cholemia cholemia NNP cord-018225-dozmy3lb 92 18 blunts blunt VBZ cord-018225-dozmy3lb 92 19 the the DT cord-018225-dozmy3lb 92 20 myocardial myocardial JJ cord-018225-dozmy3lb 92 21 contractile contractile JJ cord-018225-dozmy3lb 92 22 response response NN cord-018225-dozmy3lb 92 23 to to IN cord-018225-dozmy3lb 92 24 sympathomimetic sympathomimetic JJ cord-018225-dozmy3lb 92 25 agents agent NNS cord-018225-dozmy3lb 92 26 . . . cord-018225-dozmy3lb 93 1 The the DT cord-018225-dozmy3lb 93 2 cardiodepressor cardiodepressor NN cord-018225-dozmy3lb 93 3 effect effect NN cord-018225-dozmy3lb 93 4 of of IN cord-018225-dozmy3lb 93 5 cholemia cholemia NN cord-018225-dozmy3lb 93 6 may may MD cord-018225-dozmy3lb 93 7 explain explain VB cord-018225-dozmy3lb 93 8 the the DT cord-018225-dozmy3lb 93 9 increased increase VBN cord-018225-dozmy3lb 93 10 tendency tendency NN cord-018225-dozmy3lb 93 11 of of IN cord-018225-dozmy3lb 93 12 patients patient NNS cord-018225-dozmy3lb 93 13 with with IN cord-018225-dozmy3lb 93 14 obstructive obstructive JJ cord-018225-dozmy3lb 93 15 jaundice jaundice NN cord-018225-dozmy3lb 93 16 to to IN cord-018225-dozmy3lb 93 17 postoperative postoperative JJ cord-018225-dozmy3lb 93 18 shock shock NN cord-018225-dozmy3lb 93 19 and and CC cord-018225-dozmy3lb 93 20 renal renal JJ cord-018225-dozmy3lb 93 21 failure failure NN cord-018225-dozmy3lb 93 22 . . . cord-018225-dozmy3lb 94 1 The the DT cord-018225-dozmy3lb 94 2 effect effect NN cord-018225-dozmy3lb 94 3 of of IN cord-018225-dozmy3lb 94 4 deep deep JJ cord-018225-dozmy3lb 94 5 jaundice jaundice NN cord-018225-dozmy3lb 94 6 on on IN cord-018225-dozmy3lb 94 7 left left JJ cord-018225-dozmy3lb 94 8 ventricular ventricular JJ cord-018225-dozmy3lb 94 9 function function NN cord-018225-dozmy3lb 94 10 was be VBD cord-018225-dozmy3lb 94 11 studied study VBN cord-018225-dozmy3lb 94 12 in in IN cord-018225-dozmy3lb 94 13 five five CD cord-018225-dozmy3lb 94 14 dogs dog NNS cord-018225-dozmy3lb 94 15 . . . cord-018225-dozmy3lb 95 1 Each each DT cord-018225-dozmy3lb 95 2 dog dog NN cord-018225-dozmy3lb 95 3 was be VBD cord-018225-dozmy3lb 95 4 studied study VBN cord-018225-dozmy3lb 95 5 before before IN cord-018225-dozmy3lb 95 6 and and CC cord-018225-dozmy3lb 95 7 2 2 CD cord-018225-dozmy3lb 95 8 weeks week NNS cord-018225-dozmy3lb 95 9 after after IN cord-018225-dozmy3lb 95 10 choledochocaval choledochocaval NNP cord-018225-dozmy3lb 95 11 anastomosis anastomosis NNP cord-018225-dozmy3lb 95 12 ( ( -LRB- cord-018225-dozmy3lb 95 13 CDCA CDCA NNP cord-018225-dozmy3lb 95 14 ) ) -RRB- cord-018225-dozmy3lb 95 15 , , , cord-018225-dozmy3lb 95 16 thus thus RB cord-018225-dozmy3lb 95 17 each each DT cord-018225-dozmy3lb 95 18 dog dog NN cord-018225-dozmy3lb 95 19 served serve VBD cord-018225-dozmy3lb 95 20 as as IN cord-018225-dozmy3lb 95 21 its -PRON- PRP$ cord-018225-dozmy3lb 95 22 own own JJ cord-018225-dozmy3lb 95 23 control control NN cord-018225-dozmy3lb 95 24 . . . cord-018225-dozmy3lb 96 1 CDCA CDCA NNP cord-018225-dozmy3lb 96 2 results result VBZ cord-018225-dozmy3lb 96 3 in in IN cord-018225-dozmy3lb 96 4 severe severe JJ cord-018225-dozmy3lb 96 5 jaundice jaundice NN cord-018225-dozmy3lb 96 6 with with IN cord-018225-dozmy3lb 96 7 minimal minimal JJ cord-018225-dozmy3lb 96 8 liver liver NN cord-018225-dozmy3lb 96 9 damage damage NN cord-018225-dozmy3lb 96 10 . . . cord-018225-dozmy3lb 97 1 Mean mean JJ cord-018225-dozmy3lb 97 2 arterial arterial JJ cord-018225-dozmy3lb 97 3 blood blood NN cord-018225-dozmy3lb 97 4 pressure pressure NN cord-018225-dozmy3lb 97 5 , , , cord-018225-dozmy3lb 97 6 end end NN cord-018225-dozmy3lb 97 7 - - HYPH cord-018225-dozmy3lb 97 8 diastolic diastolic JJ cord-018225-dozmy3lb 97 9 left leave VBN cord-018225-dozmy3lb 97 10 ventricular ventricular JJ cord-018225-dozmy3lb 97 11 pressure pressure NN cord-018225-dozmy3lb 97 12 , , , cord-018225-dozmy3lb 97 13 and and CC cord-018225-dozmy3lb 97 14 maximal maximal JJ cord-018225-dozmy3lb 97 15 rate rate NN cord-018225-dozmy3lb 97 16 of of IN cord-018225-dozmy3lb 97 17 increase increase NN cord-018225-dozmy3lb 97 18 in in IN cord-018225-dozmy3lb 97 19 left left JJ cord-018225-dozmy3lb 97 20 ventricular ventricular JJ cord-018225-dozmy3lb 97 21 pressure pressure NN cord-018225-dozmy3lb 97 22 ( ( -LRB- cord-018225-dozmy3lb 97 23 dp dp NNP cord-018225-dozmy3lb 97 24 / / SYM cord-018225-dozmy3lb 97 25 dt dt NNP cord-018225-dozmy3lb 97 26 ) ) -RRB- cord-018225-dozmy3lb 97 27 were be VBD cord-018225-dozmy3lb 97 28 obtained obtain VBN cord-018225-dozmy3lb 97 29 by by IN cord-018225-dozmy3lb 97 30 retrograde retrograde JJ cord-018225-dozmy3lb 97 31 catheterization catheterization NN cord-018225-dozmy3lb 97 32 of of IN cord-018225-dozmy3lb 97 33 the the DT cord-018225-dozmy3lb 97 34 aorta aorta NN cord-018225-dozmy3lb 97 35 and and CC cord-018225-dozmy3lb 97 36 left left JJ cord-018225-dozmy3lb 97 37 ventricle ventricle NN cord-018225-dozmy3lb 97 38 . . . cord-018225-dozmy3lb 98 1 Systolic systolic JJ cord-018225-dozmy3lb 98 2 time time NN cord-018225-dozmy3lb 98 3 intervals interval NNS cord-018225-dozmy3lb 98 4 ( ( -LRB- cord-018225-dozmy3lb 98 5 pre pre JJ cord-018225-dozmy3lb 98 6 - - JJ cord-018225-dozmy3lb 98 7 ejection ejection JJ cord-018225-dozmy3lb 98 8 period period NN cord-018225-dozmy3lb 98 9 ( ( -LRB- cord-018225-dozmy3lb 98 10 PEP pep NN cord-018225-dozmy3lb 98 11 ) ) -RRB- cord-018225-dozmy3lb 98 12 and and CC cord-018225-dozmy3lb 98 13 left leave VBD cord-018225-dozmy3lb 98 14 ventricular ventricular JJ cord-018225-dozmy3lb 98 15 ejection ejection NN cord-018225-dozmy3lb 98 16 time time NN cord-018225-dozmy3lb 98 17 ( ( -LRB- cord-018225-dozmy3lb 98 18 LVET LVET NNP cord-018225-dozmy3lb 98 19 ) ) -RRB- cord-018225-dozmy3lb 98 20 ) ) -RRB- cord-018225-dozmy3lb 98 21 were be VBD cord-018225-dozmy3lb 98 22 measured measure VBN cord-018225-dozmy3lb 98 23 with with IN cord-018225-dozmy3lb 98 24 simultaneous simultaneous JJ cord-018225-dozmy3lb 98 25 ECG ECG NNP cord-018225-dozmy3lb 98 26 and and CC cord-018225-dozmy3lb 98 27 aortic aortic JJ cord-018225-dozmy3lb 98 28 pulse pulse NN cord-018225-dozmy3lb 98 29 tracings tracing NNS cord-018225-dozmy3lb 98 30 . . . cord-018225-dozmy3lb 99 1 Systolic systolic JJ cord-018225-dozmy3lb 99 2 time time NN cord-018225-dozmy3lb 99 3 intervals interval NNS cord-018225-dozmy3lb 99 4 were be VBD cord-018225-dozmy3lb 99 5 measured measure VBN cord-018225-dozmy3lb 99 6 before before RB cord-018225-dozmy3lb 99 7 and and CC cord-018225-dozmy3lb 99 8 after after IN cord-018225-dozmy3lb 99 9 intravenous intravenous JJ cord-018225-dozmy3lb 99 10 injection injection NN cord-018225-dozmy3lb 99 11 of of IN cord-018225-dozmy3lb 99 12 ouabain ouabain NN cord-018225-dozmy3lb 99 13 . . . cord-018225-dozmy3lb 100 1 The the DT cord-018225-dozmy3lb 100 2 findings finding NNS cord-018225-dozmy3lb 100 3 revealed reveal VBD cord-018225-dozmy3lb 100 4 that that IN cord-018225-dozmy3lb 100 5 deep deep JJ cord-018225-dozmy3lb 100 6 jaundice jaundice NN cord-018225-dozmy3lb 100 7 was be VBD cord-018225-dozmy3lb 100 8 associated associate VBN cord-018225-dozmy3lb 100 9 with with IN cord-018225-dozmy3lb 100 10 impaired impaired JJ cord-018225-dozmy3lb 100 11 left left JJ cord-018225-dozmy3lb 100 12 ventricular ventricular JJ cord-018225-dozmy3lb 100 13 performance performance NN cord-018225-dozmy3lb 100 14 . . . cord-018225-dozmy3lb 101 1 There there EX cord-018225-dozmy3lb 101 2 was be VBD cord-018225-dozmy3lb 101 3 a a DT cord-018225-dozmy3lb 101 4 decrease decrease NN cord-018225-dozmy3lb 101 5 in in IN cord-018225-dozmy3lb 101 6 dp dp NNP cord-018225-dozmy3lb 101 7 / / SYM cord-018225-dozmy3lb 101 8 dt dt XX cord-018225-dozmy3lb 101 9 without without IN cord-018225-dozmy3lb 101 10 changes change NNS cord-018225-dozmy3lb 101 11 to to IN cord-018225-dozmy3lb 101 12 arterial arterial JJ cord-018225-dozmy3lb 101 13 pressure pressure NN cord-018225-dozmy3lb 101 14 , , , cord-018225-dozmy3lb 101 15 heart heart NN cord-018225-dozmy3lb 101 16 rate rate NN cord-018225-dozmy3lb 101 17 , , , cord-018225-dozmy3lb 101 18 or or CC cord-018225-dozmy3lb 101 19 preload preload NN cord-018225-dozmy3lb 101 20 . . . cord-018225-dozmy3lb 102 1 Moreover moreover RB cord-018225-dozmy3lb 102 2 , , , cord-018225-dozmy3lb 102 3 there there EX cord-018225-dozmy3lb 102 4 was be VBD cord-018225-dozmy3lb 102 5 an an DT cord-018225-dozmy3lb 102 6 associated associated JJ cord-018225-dozmy3lb 102 7 increase increase NN cord-018225-dozmy3lb 102 8 in in IN cord-018225-dozmy3lb 102 9 mean mean JJ cord-018225-dozmy3lb 102 10 left left JJ cord-018225-dozmy3lb 102 11 ventricular ventricular JJ cord-018225-dozmy3lb 102 12 PEP pep NN cord-018225-dozmy3lb 102 13 , , , cord-018225-dozmy3lb 102 14 and and CC cord-018225-dozmy3lb 102 15 a a DT cord-018225-dozmy3lb 102 16 decrease decrease NN cord-018225-dozmy3lb 102 17 in in IN cord-018225-dozmy3lb 102 18 LVET LVET NNP cord-018225-dozmy3lb 102 19 when when WRB cord-018225-dozmy3lb 102 20 compared compare VBN cord-018225-dozmy3lb 102 21 with with IN cord-018225-dozmy3lb 102 22 predicted predict VBN cord-018225-dozmy3lb 102 23 values value NNS cord-018225-dozmy3lb 102 24 . . . cord-018225-dozmy3lb 103 1 Although although IN cord-018225-dozmy3lb 103 2 administration administration NN cord-018225-dozmy3lb 103 3 of of IN cord-018225-dozmy3lb 103 4 ouabain ouabain NN cord-018225-dozmy3lb 103 5 in in IN cord-018225-dozmy3lb 103 6 normal normal JJ cord-018225-dozmy3lb 103 7 dogs dog NNS cord-018225-dozmy3lb 103 8 ( ( -LRB- cord-018225-dozmy3lb 103 9 i.e. i.e. FW cord-018225-dozmy3lb 103 10 pre pre JJ cord-018225-dozmy3lb 103 11 - - JJ cord-018225-dozmy3lb 103 12 CDCA CDCA NNP cord-018225-dozmy3lb 103 13 ) ) -RRB- cord-018225-dozmy3lb 103 14 was be VBD cord-018225-dozmy3lb 103 15 associated associate VBN cord-018225-dozmy3lb 103 16 with with IN cord-018225-dozmy3lb 103 17 decreased decreased JJ cord-018225-dozmy3lb 103 18 PEP pep NN cord-018225-dozmy3lb 103 19 , , , cord-018225-dozmy3lb 103 20 no no DT cord-018225-dozmy3lb 103 21 effect effect NN cord-018225-dozmy3lb 103 22 was be VBD cord-018225-dozmy3lb 103 23 observed observe VBN cord-018225-dozmy3lb 103 24 in in IN cord-018225-dozmy3lb 103 25 deeply deeply RB cord-018225-dozmy3lb 103 26 jaundiced jaundiced JJ cord-018225-dozmy3lb 103 27 animals animal NNS cord-018225-dozmy3lb 103 28 . . . cord-018225-dozmy3lb 104 1 48 48 CD cord-018225-dozmy3lb 104 2 Deep deep JJ cord-018225-dozmy3lb 104 3 jaundice jaundice NN cord-018225-dozmy3lb 104 4 may may MD cord-018225-dozmy3lb 104 5 have have VB cord-018225-dozmy3lb 104 6 hemodynamic hemodynamic JJ cord-018225-dozmy3lb 104 7 consequences consequence NNS cord-018225-dozmy3lb 104 8 even even RB cord-018225-dozmy3lb 104 9 when when WRB cord-018225-dozmy3lb 104 10 liver liver NN cord-018225-dozmy3lb 104 11 function function NN cord-018225-dozmy3lb 104 12 is be VBZ cord-018225-dozmy3lb 104 13 relatively relatively RB cord-018225-dozmy3lb 104 14 intact intact JJ cord-018225-dozmy3lb 104 15 . . . cord-018225-dozmy3lb 105 1 It -PRON- PRP cord-018225-dozmy3lb 105 2 is be VBZ cord-018225-dozmy3lb 105 3 associated associate VBN cord-018225-dozmy3lb 105 4 with with IN cord-018225-dozmy3lb 105 5 impaired impaired JJ cord-018225-dozmy3lb 105 6 left left JJ cord-018225-dozmy3lb 105 7 ventricular ventricular JJ cord-018225-dozmy3lb 105 8 performance performance NN cord-018225-dozmy3lb 105 9 that that WDT cord-018225-dozmy3lb 105 10 is be VBZ cord-018225-dozmy3lb 105 11 refractory refractory JJ cord-018225-dozmy3lb 105 12 to to IN cord-018225-dozmy3lb 105 13 cardiac cardiac JJ cord-018225-dozmy3lb 105 14 glycosides glycoside NNS cord-018225-dozmy3lb 105 15 in in IN cord-018225-dozmy3lb 105 16 this this DT cord-018225-dozmy3lb 105 17 animal animal NN cord-018225-dozmy3lb 105 18 model model NN cord-018225-dozmy3lb 105 19 . . . cord-018225-dozmy3lb 106 1 The the DT cord-018225-dozmy3lb 106 2 hemodynamic hemodynamic JJ cord-018225-dozmy3lb 106 3 manifestations manifestation NNS cord-018225-dozmy3lb 106 4 of of IN cord-018225-dozmy3lb 106 5 advanced advanced JJ cord-018225-dozmy3lb 106 6 liver liver NN cord-018225-dozmy3lb 106 7 failure failure NN cord-018225-dozmy3lb 106 8 with with IN cord-018225-dozmy3lb 106 9 jaundice jaundice NN cord-018225-dozmy3lb 106 10 are be VBP cord-018225-dozmy3lb 106 11 well well RB cord-018225-dozmy3lb 106 12 described describe VBN cord-018225-dozmy3lb 106 13 , , , cord-018225-dozmy3lb 106 14 and and CC cord-018225-dozmy3lb 106 15 are be VBP cord-018225-dozmy3lb 106 16 basically basically RB cord-018225-dozmy3lb 106 17 a a DT cord-018225-dozmy3lb 106 18 ' ' `` cord-018225-dozmy3lb 106 19 high high JJ cord-018225-dozmy3lb 106 20 output output NN cord-018225-dozmy3lb 106 21 - - HYPH cord-018225-dozmy3lb 106 22 low low NN cord-018225-dozmy3lb 106 23 resistance resistance NN cord-018225-dozmy3lb 106 24 ' ' '' cord-018225-dozmy3lb 106 25 state state NN cord-018225-dozmy3lb 106 26 . . . cord-018225-dozmy3lb 107 1 This this DT cord-018225-dozmy3lb 107 2 paper paper NN cord-018225-dozmy3lb 107 3 suggests suggest VBZ cord-018225-dozmy3lb 107 4 that that IN cord-018225-dozmy3lb 107 5 jaundice jaundice NN cord-018225-dozmy3lb 107 6 has have VBZ cord-018225-dozmy3lb 107 7 its -PRON- PRP$ cord-018225-dozmy3lb 107 8 own own JJ cord-018225-dozmy3lb 107 9 effects effect NNS cord-018225-dozmy3lb 107 10 on on IN cord-018225-dozmy3lb 107 11 cardiac cardiac JJ cord-018225-dozmy3lb 107 12 function function NN cord-018225-dozmy3lb 107 13 independent independent JJ cord-018225-dozmy3lb 107 14 of of IN cord-018225-dozmy3lb 107 15 liver liver NN cord-018225-dozmy3lb 107 16 failure failure NN cord-018225-dozmy3lb 107 17 . . . cord-018225-dozmy3lb 108 1 The the DT cord-018225-dozmy3lb 108 2 authors author NNS cord-018225-dozmy3lb 108 3 are be VBP cord-018225-dozmy3lb 108 4 clearly clearly RB cord-018225-dozmy3lb 108 5 original original JJ cord-018225-dozmy3lb 108 6 thinkers thinker NNS cord-018225-dozmy3lb 108 7 who who WP cord-018225-dozmy3lb 108 8 have have VBP cord-018225-dozmy3lb 108 9 devised devise VBN cord-018225-dozmy3lb 108 10 an an DT cord-018225-dozmy3lb 108 11 animal animal NN cord-018225-dozmy3lb 108 12 model model NN cord-018225-dozmy3lb 108 13 to to TO cord-018225-dozmy3lb 108 14 shed shed VB cord-018225-dozmy3lb 108 15 light light NN cord-018225-dozmy3lb 108 16 on on IN cord-018225-dozmy3lb 108 17 a a DT cord-018225-dozmy3lb 108 18 clinical clinical JJ cord-018225-dozmy3lb 108 19 problem problem NN cord-018225-dozmy3lb 108 20 . . . cord-018225-dozmy3lb 109 1 The the DT cord-018225-dozmy3lb 109 2 model model NN cord-018225-dozmy3lb 109 3 is be VBZ cord-018225-dozmy3lb 109 4 relevant relevant JJ cord-018225-dozmy3lb 109 5 to to IN cord-018225-dozmy3lb 109 6 patients patient NNS cord-018225-dozmy3lb 109 7 with with IN cord-018225-dozmy3lb 109 8 jaundice jaundice NN cord-018225-dozmy3lb 109 9 associated associate VBN cord-018225-dozmy3lb 109 10 with with IN cord-018225-dozmy3lb 109 11 multiple multiple JJ cord-018225-dozmy3lb 109 12 organ organ NN cord-018225-dozmy3lb 109 13 failure failure NN cord-018225-dozmy3lb 109 14 , , , cord-018225-dozmy3lb 109 15 as as RB cord-018225-dozmy3lb 109 16 well well RB cord-018225-dozmy3lb 109 17 as as IN cord-018225-dozmy3lb 109 18 obstructive obstructive JJ cord-018225-dozmy3lb 109 19 jaundice jaundice NN cord-018225-dozmy3lb 110 1 This this DT cord-018225-dozmy3lb 110 2 is be VBZ cord-018225-dozmy3lb 110 3 a a DT cord-018225-dozmy3lb 110 4 small small JJ cord-018225-dozmy3lb 110 5 animal animal NN cord-018225-dozmy3lb 110 6 study study NN cord-018225-dozmy3lb 110 7 . . . cord-018225-dozmy3lb 111 1 The the DT cord-018225-dozmy3lb 111 2 methods method NNS cord-018225-dozmy3lb 111 3 of of IN cord-018225-dozmy3lb 111 4 assessment assessment NN cord-018225-dozmy3lb 111 5 of of IN cord-018225-dozmy3lb 111 6 left left JJ cord-018225-dozmy3lb 111 7 ventricular ventricular JJ cord-018225-dozmy3lb 111 8 function function NN cord-018225-dozmy3lb 111 9 are be VBP cord-018225-dozmy3lb 111 10 probably probably RB cord-018225-dozmy3lb 111 11 valid valid JJ cord-018225-dozmy3lb 111 12 , , , cord-018225-dozmy3lb 111 13 but but CC cord-018225-dozmy3lb 111 14 are be VBP cord-018225-dozmy3lb 111 15 not not RB cord-018225-dozmy3lb 111 16 conventional conventional JJ cord-018225-dozmy3lb 111 17 . . . cord-018225-dozmy3lb 112 1 Patients patient NNS cord-018225-dozmy3lb 112 2 with with IN cord-018225-dozmy3lb 112 3 multiple multiple JJ cord-018225-dozmy3lb 112 4 organ organ NN cord-018225-dozmy3lb 112 5 failure failure NN cord-018225-dozmy3lb 112 6 are be VBP cord-018225-dozmy3lb 112 7 frequently frequently RB cord-018225-dozmy3lb 112 8 jaundiced jaundiced JJ cord-018225-dozmy3lb 112 9 , , , cord-018225-dozmy3lb 112 10 and and CC cord-018225-dozmy3lb 112 11 in in IN cord-018225-dozmy3lb 112 12 this this DT cord-018225-dozmy3lb 112 13 setting setting NN cord-018225-dozmy3lb 112 14 , , , cord-018225-dozmy3lb 112 15 plasma plasma NN cord-018225-dozmy3lb 112 16 bilirubin bilirubin NN cord-018225-dozmy3lb 112 17 concentrations concentration NNS cord-018225-dozmy3lb 112 18 may may MD cord-018225-dozmy3lb 112 19 be be VB cord-018225-dozmy3lb 112 20 grossly grossly RB cord-018225-dozmy3lb 112 21 elevated elevated JJ cord-018225-dozmy3lb 112 22 . . . cord-018225-dozmy3lb 113 1 Such such JJ cord-018225-dozmy3lb 113 2 patients patient NNS cord-018225-dozmy3lb 113 3 often often RB cord-018225-dozmy3lb 113 4 also also RB cord-018225-dozmy3lb 113 5 have have VBP cord-018225-dozmy3lb 113 6 severe severe JJ cord-018225-dozmy3lb 113 7 hemodynamic hemodynamic JJ cord-018225-dozmy3lb 113 8 compromise compromise NN cord-018225-dozmy3lb 113 9 that that WDT cord-018225-dozmy3lb 113 10 can can MD cord-018225-dozmy3lb 113 11 be be VB cord-018225-dozmy3lb 113 12 refractory refractory JJ cord-018225-dozmy3lb 113 13 to to IN cord-018225-dozmy3lb 113 14 inotropic inotropic NNP cord-018225-dozmy3lb 113 15 agents agent NNS cord-018225-dozmy3lb 113 16 . . . cord-018225-dozmy3lb 114 1 Although although IN cord-018225-dozmy3lb 114 2 this this DT cord-018225-dozmy3lb 114 3 paper paper NN cord-018225-dozmy3lb 114 4 does do VBZ cord-018225-dozmy3lb 114 5 not not RB cord-018225-dozmy3lb 114 6 offer offer VB cord-018225-dozmy3lb 114 7 a a DT cord-018225-dozmy3lb 114 8 solution solution NN cord-018225-dozmy3lb 114 9 to to IN cord-018225-dozmy3lb 114 10 this this DT cord-018225-dozmy3lb 114 11 problem problem NN cord-018225-dozmy3lb 114 12 , , , cord-018225-dozmy3lb 114 13 it -PRON- PRP cord-018225-dozmy3lb 114 14 does do VBZ cord-018225-dozmy3lb 114 15 propose propose VB cord-018225-dozmy3lb 114 16 a a DT cord-018225-dozmy3lb 114 17 plausible plausible JJ cord-018225-dozmy3lb 114 18 mechanism mechanism NN cord-018225-dozmy3lb 114 19 . . . cord-018225-dozmy3lb 114 20 _SP cord-018225-dozmy3lb 115 1 The the DT cord-018225-dozmy3lb 115 2 incidence incidence NN cord-018225-dozmy3lb 115 3 of of IN cord-018225-dozmy3lb 115 4 hypoxic hypoxic JJ cord-018225-dozmy3lb 115 5 hepatitis hepatitis NN cord-018225-dozmy3lb 115 6 was be VBD cord-018225-dozmy3lb 115 7 prospectively prospectively RB cord-018225-dozmy3lb 115 8 studied study VBN cord-018225-dozmy3lb 115 9 for for IN cord-018225-dozmy3lb 115 10 1 1 CD cord-018225-dozmy3lb 115 11 year year NN cord-018225-dozmy3lb 115 12 in in IN cord-018225-dozmy3lb 115 13 a a DT cord-018225-dozmy3lb 115 14 group group NN cord-018225-dozmy3lb 115 15 of of IN cord-018225-dozmy3lb 115 16 high high JJ cord-018225-dozmy3lb 115 17 - - HYPH cord-018225-dozmy3lb 115 18 risk risk NN cord-018225-dozmy3lb 115 19 patients patient NNS cord-018225-dozmy3lb 115 20 suffering suffer VBG cord-018225-dozmy3lb 115 21 from from IN cord-018225-dozmy3lb 115 22 low low JJ cord-018225-dozmy3lb 115 23 cardiac cardiac JJ cord-018225-dozmy3lb 115 24 output output NN cord-018225-dozmy3lb 115 25 in in IN cord-018225-dozmy3lb 115 26 a a DT cord-018225-dozmy3lb 115 27 coronary coronary JJ cord-018225-dozmy3lb 115 28 care care NN cord-018225-dozmy3lb 115 29 unit unit NN cord-018225-dozmy3lb 115 30 . . . cord-018225-dozmy3lb 116 1 Hypoxic hypoxic JJ cord-018225-dozmy3lb 116 2 hepatitis hepatitis NN cord-018225-dozmy3lb 116 3 , , , cord-018225-dozmy3lb 116 4 defined define VBN cord-018225-dozmy3lb 116 5 as as IN cord-018225-dozmy3lb 116 6 an an DT cord-018225-dozmy3lb 116 7 increase increase NN cord-018225-dozmy3lb 116 8 in in IN cord-018225-dozmy3lb 116 9 serum serum NN cord-018225-dozmy3lb 116 10 aminotransferase aminotransferase NN cord-018225-dozmy3lb 116 11 activity activity NN cord-018225-dozmy3lb 116 12 of of IN cord-018225-dozmy3lb 116 13 at at RB cord-018225-dozmy3lb 116 14 least least RBS cord-018225-dozmy3lb 116 15 20 20 CD cord-018225-dozmy3lb 116 16 times time NNS cord-018225-dozmy3lb 116 17 the the DT cord-018225-dozmy3lb 116 18 upper upper JJ cord-018225-dozmy3lb 116 19 limit limit NN cord-018225-dozmy3lb 116 20 of of IN cord-018225-dozmy3lb 116 21 normal normal JJ cord-018225-dozmy3lb 116 22 without without IN cord-018225-dozmy3lb 116 23 any any DT cord-018225-dozmy3lb 116 24 other other JJ cord-018225-dozmy3lb 116 25 cause cause NN cord-018225-dozmy3lb 116 26 for for IN cord-018225-dozmy3lb 116 27 hepatic hepatic JJ cord-018225-dozmy3lb 116 28 necrosis necrosis NN cord-018225-dozmy3lb 116 29 , , , cord-018225-dozmy3lb 116 30 was be VBD cord-018225-dozmy3lb 116 31 observed observe VBN cord-018225-dozmy3lb 116 32 in in IN cord-018225-dozmy3lb 116 33 20 20 CD cord-018225-dozmy3lb 116 34 patients patient NNS cord-018225-dozmy3lb 116 35 . . . cord-018225-dozmy3lb 117 1 This this DT cord-018225-dozmy3lb 117 2 represents represent VBZ cord-018225-dozmy3lb 117 3 2.6 2.6 CD cord-018225-dozmy3lb 117 4 % % NN cord-018225-dozmy3lb 117 5 of of IN cord-018225-dozmy3lb 117 6 the the DT cord-018225-dozmy3lb 117 7 766 766 CD cord-018225-dozmy3lb 117 8 patients patient NNS cord-018225-dozmy3lb 117 9 admitted admit VBN cord-018225-dozmy3lb 117 10 to to IN cord-018225-dozmy3lb 117 11 the the DT cord-018225-dozmy3lb 117 12 unit unit NN cord-018225-dozmy3lb 117 13 during during IN cord-018225-dozmy3lb 117 14 this this DT cord-018225-dozmy3lb 117 15 period period NN cord-018225-dozmy3lb 117 16 , , , cord-018225-dozmy3lb 117 17 and and CC cord-018225-dozmy3lb 117 18 21.9 21.9 CD cord-018225-dozmy3lb 117 19 % % NN cord-018225-dozmy3lb 117 20 of of IN cord-018225-dozmy3lb 117 21 the the DT cord-018225-dozmy3lb 117 22 91 91 CD cord-018225-dozmy3lb 117 23 patients patient NNS cord-018225-dozmy3lb 117 24 suffering suffer VBG cord-018225-dozmy3lb 117 25 from from IN cord-018225-dozmy3lb 117 26 low low JJ cord-018225-dozmy3lb 117 27 cardiac cardiac JJ cord-018225-dozmy3lb 117 28 output output NN cord-018225-dozmy3lb 117 29 . . . cord-018225-dozmy3lb 118 1 Clinical clinical JJ cord-018225-dozmy3lb 118 2 , , , cord-018225-dozmy3lb 118 3 biological biological JJ cord-018225-dozmy3lb 118 4 , , , cord-018225-dozmy3lb 118 5 and and CC cord-018225-dozmy3lb 118 6 hemodynamic hemodynamic JJ cord-018225-dozmy3lb 118 7 data datum NNS cord-018225-dozmy3lb 118 8 were be VBD cord-018225-dozmy3lb 118 9 compared compare VBN cord-018225-dozmy3lb 118 10 between between IN cord-018225-dozmy3lb 118 11 20 20 CD cord-018225-dozmy3lb 118 12 patients patient NNS cord-018225-dozmy3lb 118 13 with with IN cord-018225-dozmy3lb 118 14 low low JJ cord-018225-dozmy3lb 118 15 cardiac cardiac JJ cord-018225-dozmy3lb 118 16 output output NN cord-018225-dozmy3lb 118 17 and and CC cord-018225-dozmy3lb 118 18 hypoxic hypoxic JJ cord-018225-dozmy3lb 118 19 hepatitis hepatitis NN cord-018225-dozmy3lb 118 20 , , , cord-018225-dozmy3lb 118 21 and and CC cord-018225-dozmy3lb 118 22 48 48 CD cord-018225-dozmy3lb 118 23 patients patient NNS cord-018225-dozmy3lb 118 24 with with IN cord-018225-dozmy3lb 118 25 low low JJ cord-018225-dozmy3lb 118 26 cardiac cardiac JJ cord-018225-dozmy3lb 118 27 output output NN cord-018225-dozmy3lb 118 28 but but CC cord-018225-dozmy3lb 118 29 without without IN cord-018225-dozmy3lb 118 30 hypoxic hypoxic JJ cord-018225-dozmy3lb 118 31 hepatitis hepatitis NN cord-018225-dozmy3lb 118 32 who who WP cord-018225-dozmy3lb 118 33 survived survive VBD cord-018225-dozmy3lb 118 34 more more JJR cord-018225-dozmy3lb 118 35 than than IN cord-018225-dozmy3lb 118 36 24 24 CD cord-018225-dozmy3lb 118 37 hour hour NN cord-018225-dozmy3lb 118 38 . . . cord-018225-dozmy3lb 119 1 In in IN cord-018225-dozmy3lb 119 2 these these DT cord-018225-dozmy3lb 119 3 two two CD cord-018225-dozmy3lb 119 4 groups group NNS cord-018225-dozmy3lb 119 5 of of IN cord-018225-dozmy3lb 119 6 patients patient NNS cord-018225-dozmy3lb 119 7 , , , cord-018225-dozmy3lb 119 8 hepatic hepatic JJ cord-018225-dozmy3lb 119 9 blood blood NN cord-018225-dozmy3lb 119 10 flow flow NN cord-018225-dozmy3lb 119 11 was be VBD cord-018225-dozmy3lb 119 12 measured measure VBN cord-018225-dozmy3lb 119 13 by by IN cord-018225-dozmy3lb 119 14 galactose galactose NN cord-018225-dozmy3lb 119 15 clearance clearance NN cord-018225-dozmy3lb 119 16 at at IN cord-018225-dozmy3lb 119 17 low low JJ cord-018225-dozmy3lb 119 18 concentration concentration NN cord-018225-dozmy3lb 119 19 . . . cord-018225-dozmy3lb 120 1 Patients patient NNS cord-018225-dozmy3lb 120 2 with with IN cord-018225-dozmy3lb 120 3 hypoxic hypoxic JJ cord-018225-dozmy3lb 120 4 hepatitis hepatitis NN cord-018225-dozmy3lb 120 5 exhibited exhibit VBD cord-018225-dozmy3lb 120 6 a a DT cord-018225-dozmy3lb 120 7 higher high JJR cord-018225-dozmy3lb 120 8 central central JJ cord-018225-dozmy3lb 120 9 venous venous JJ cord-018225-dozmy3lb 120 10 pressure pressure NN cord-018225-dozmy3lb 120 11 ( ( -LRB- cord-018225-dozmy3lb 120 12 90 90 CD cord-018225-dozmy3lb 120 13 % % NN cord-018225-dozmy3lb 120 14 versus versus IN cord-018225-dozmy3lb 120 15 38 38 CD cord-018225-dozmy3lb 120 16 % % NN cord-018225-dozmy3lb 120 17 , , , cord-018225-dozmy3lb 120 18 p p NN cord-018225-dozmy3lb 120 19 < < XX cord-018225-dozmy3lb 120 20 0.001 0.001 CD cord-018225-dozmy3lb 120 21 ) ) -RRB- cord-018225-dozmy3lb 120 22 , , , cord-018225-dozmy3lb 120 23 as as RB cord-018225-dozmy3lb 120 24 well well RB cord-018225-dozmy3lb 120 25 as as IN cord-018225-dozmy3lb 120 26 a a DT cord-018225-dozmy3lb 120 27 lower low JJR cord-018225-dozmy3lb 120 28 hepatic hepatic JJ cord-018225-dozmy3lb 120 29 blood blood NN cord-018225-dozmy3lb 120 30 flow flow NN cord-018225-dozmy3lb 120 31 ( ( -LRB- cord-018225-dozmy3lb 120 32 867 867 CD cord-018225-dozmy3lb 120 33 + + CC cord-018225-dozmy3lb 120 34 /-377 /-377 CC cord-018225-dozmy3lb 120 35 ml ml NNP cord-018225-dozmy3lb 120 36 / / SYM cord-018225-dozmy3lb 120 37 min min NN cord-018225-dozmy3lb 120 38 versus versus IN cord-018225-dozmy3lb 120 39 1429 1429 CD cord-018225-dozmy3lb 121 1 + + CC cord-018225-dozmy3lb 122 1 /-644 /-644 NFP cord-018225-dozmy3lb 122 2 ml ml NNP cord-018225-dozmy3lb 122 3 / / SYM cord-018225-dozmy3lb 122 4 min min NNP cord-018225-dozmy3lb 122 5 , , , cord-018225-dozmy3lb 122 6 p p NN cord-018225-dozmy3lb 122 7 = = SYM cord-018225-dozmy3lb 122 8 0.001 0.001 CD cord-018225-dozmy3lb 122 9 ) ) -RRB- cord-018225-dozmy3lb 122 10 . . . cord-018225-dozmy3lb 123 1 In in IN cord-018225-dozmy3lb 123 2 conclusion conclusion NN cord-018225-dozmy3lb 123 3 , , , cord-018225-dozmy3lb 123 4 although although IN cord-018225-dozmy3lb 123 5 it -PRON- PRP cord-018225-dozmy3lb 123 6 is be VBZ cord-018225-dozmy3lb 123 7 considered consider VBN cord-018225-dozmy3lb 123 8 a a DT cord-018225-dozmy3lb 123 9 rare rare JJ cord-018225-dozmy3lb 123 10 hepatic hepatic JJ cord-018225-dozmy3lb 123 11 disorder disorder NN cord-018225-dozmy3lb 123 12 , , , cord-018225-dozmy3lb 123 13 hypoxic hypoxic JJ cord-018225-dozmy3lb 123 14 hepatitis hepatitis NN cord-018225-dozmy3lb 123 15 is be VBZ cord-018225-dozmy3lb 123 16 frequent frequent JJ cord-018225-dozmy3lb 123 17 in in IN cord-018225-dozmy3lb 123 18 patients patient NNS cord-018225-dozmy3lb 123 19 with with IN cord-018225-dozmy3lb 123 20 low low JJ cord-018225-dozmy3lb 123 21 cardiac cardiac JJ cord-018225-dozmy3lb 123 22 output output NN cord-018225-dozmy3lb 123 23 admitted admit VBD cord-018225-dozmy3lb 123 24 to to IN cord-018225-dozmy3lb 123 25 the the DT cord-018225-dozmy3lb 123 26 coronary coronary JJ cord-018225-dozmy3lb 123 27 care care NN cord-018225-dozmy3lb 123 28 unit unit NN cord-018225-dozmy3lb 123 29 , , , cord-018225-dozmy3lb 123 30 and and CC cord-018225-dozmy3lb 123 31 is be VBZ cord-018225-dozmy3lb 123 32 associated associate VBN cord-018225-dozmy3lb 123 33 with with IN cord-018225-dozmy3lb 123 34 a a DT cord-018225-dozmy3lb 123 35 decrease decrease NN cord-018225-dozmy3lb 123 36 in in IN cord-018225-dozmy3lb 123 37 hepatic hepatic JJ cord-018225-dozmy3lb 123 38 blood blood NN cord-018225-dozmy3lb 123 39 flow flow NN cord-018225-dozmy3lb 123 40 , , , cord-018225-dozmy3lb 123 41 and and CC cord-018225-dozmy3lb 123 42 passive passive JJ cord-018225-dozmy3lb 123 43 hepatic hepatic JJ cord-018225-dozmy3lb 123 44 venous venous JJ cord-018225-dozmy3lb 123 45 congestion congestion NN cord-018225-dozmy3lb 123 46 . . . cord-018225-dozmy3lb 124 1 Over over IN cord-018225-dozmy3lb 124 2 a a DT cord-018225-dozmy3lb 124 3 1-year 1-year CD cord-018225-dozmy3lb 124 4 period period NN cord-018225-dozmy3lb 124 5 in in IN cord-018225-dozmy3lb 124 6 a a DT cord-018225-dozmy3lb 124 7 Belgian belgian JJ cord-018225-dozmy3lb 124 8 coronary coronary JJ cord-018225-dozmy3lb 124 9 care care NN cord-018225-dozmy3lb 124 10 unit unit NN cord-018225-dozmy3lb 124 11 , , , cord-018225-dozmy3lb 124 12 91 91 CD cord-018225-dozmy3lb 124 13 patients patient NNS cord-018225-dozmy3lb 124 14 were be VBD cord-018225-dozmy3lb 124 15 identified identify VBN cord-018225-dozmy3lb 124 16 as as IN cord-018225-dozmy3lb 124 17 having have VBG cord-018225-dozmy3lb 124 18 a a DT cord-018225-dozmy3lb 124 19 low low JJ cord-018225-dozmy3lb 124 20 cardiac cardiac JJ cord-018225-dozmy3lb 124 21 output output NN cord-018225-dozmy3lb 124 22 using use VBG cord-018225-dozmy3lb 124 23 clinical clinical JJ cord-018225-dozmy3lb 124 24 criteria criterion NNS cord-018225-dozmy3lb 124 25 . . . cord-018225-dozmy3lb 125 1 Hypoxic hypoxic JJ cord-018225-dozmy3lb 125 2 ( ( -LRB- cord-018225-dozmy3lb 125 3 ischemic ischemic JJ cord-018225-dozmy3lb 125 4 ) ) -RRB- cord-018225-dozmy3lb 125 5 hepatitis hepatitis NN cord-018225-dozmy3lb 125 6 ( ( -LRB- cord-018225-dozmy3lb 125 7 HH HH NNP cord-018225-dozmy3lb 125 8 ) ) -RRB- cord-018225-dozmy3lb 125 9 was be VBD cord-018225-dozmy3lb 125 10 said say VBN cord-018225-dozmy3lb 125 11 to to TO cord-018225-dozmy3lb 125 12 be be VB cord-018225-dozmy3lb 125 13 present present JJ cord-018225-dozmy3lb 125 14 if if IN cord-018225-dozmy3lb 125 15 there there EX cord-018225-dozmy3lb 125 16 was be VBD cord-018225-dozmy3lb 125 17 a a DT cord-018225-dozmy3lb 125 18 clinical clinical JJ cord-018225-dozmy3lb 125 19 setting setting NN cord-018225-dozmy3lb 125 20 of of IN cord-018225-dozmy3lb 125 21 circulatory circulatory JJ cord-018225-dozmy3lb 125 22 failure failure NN cord-018225-dozmy3lb 125 23 , , , cord-018225-dozmy3lb 125 24 a a DT cord-018225-dozmy3lb 125 25 sharp sharp JJ cord-018225-dozmy3lb 125 26 but but CC cord-018225-dozmy3lb 125 27 transient transient JJ cord-018225-dozmy3lb 125 28 increase increase NN cord-018225-dozmy3lb 125 29 in in IN cord-018225-dozmy3lb 125 30 serum serum NN cord-018225-dozmy3lb 125 31 aminotransferase aminotransferase NN cord-018225-dozmy3lb 125 32 activities activity NNS cord-018225-dozmy3lb 125 33 of of IN cord-018225-dozmy3lb 125 34 at at RB cord-018225-dozmy3lb 125 35 least least RBS cord-018225-dozmy3lb 125 36 20 20 CD cord-018225-dozmy3lb 125 37 times time NNS cord-018225-dozmy3lb 125 38 the the DT cord-018225-dozmy3lb 125 39 upper upper JJ cord-018225-dozmy3lb 125 40 limit limit NN cord-018225-dozmy3lb 125 41 of of IN cord-018225-dozmy3lb 125 42 normal normal JJ cord-018225-dozmy3lb 125 43 , , , cord-018225-dozmy3lb 125 44 and and CC cord-018225-dozmy3lb 125 45 after after IN cord-018225-dozmy3lb 125 46 exclusion exclusion NN cord-018225-dozmy3lb 125 47 of of IN cord-018225-dozmy3lb 125 48 other other JJ cord-018225-dozmy3lb 125 49 causes cause NNS cord-018225-dozmy3lb 125 50 of of IN cord-018225-dozmy3lb 125 51 hepatic hepatic JJ cord-018225-dozmy3lb 125 52 necrosis necrosis NN cord-018225-dozmy3lb 125 53 . . . cord-018225-dozmy3lb 126 1 Of of IN cord-018225-dozmy3lb 126 2 the the DT cord-018225-dozmy3lb 126 3 91 91 CD cord-018225-dozmy3lb 126 4 patients patient NNS cord-018225-dozmy3lb 126 5 , , , cord-018225-dozmy3lb 126 6 20 20 CD cord-018225-dozmy3lb 126 7 developed develop VBN cord-018225-dozmy3lb 126 8 HH HH NNP cord-018225-dozmy3lb 126 9 ( ( -LRB- cord-018225-dozmy3lb 126 10 2.6 2.6 CD cord-018225-dozmy3lb 126 11 % % NN cord-018225-dozmy3lb 126 12 of of IN cord-018225-dozmy3lb 126 13 admissions admission NNS cord-018225-dozmy3lb 126 14 to to IN cord-018225-dozmy3lb 126 15 the the DT cord-018225-dozmy3lb 126 16 coronary coronary JJ cord-018225-dozmy3lb 126 17 care care NN cord-018225-dozmy3lb 126 18 unit unit NN cord-018225-dozmy3lb 126 19 ; ; : cord-018225-dozmy3lb 126 20 21.9 21.9 CD cord-018225-dozmy3lb 126 21 % % NN cord-018225-dozmy3lb 126 22 of of IN cord-018225-dozmy3lb 126 23 patients patient NNS cord-018225-dozmy3lb 126 24 with with IN cord-018225-dozmy3lb 126 25 low low JJ cord-018225-dozmy3lb 126 26 cardiac cardiac JJ cord-018225-dozmy3lb 126 27 output output NN cord-018225-dozmy3lb 126 28 ) ) -RRB- cord-018225-dozmy3lb 126 29 , , , cord-018225-dozmy3lb 126 30 48 48 CD cord-018225-dozmy3lb 126 31 did do VBD cord-018225-dozmy3lb 126 32 not not RB cord-018225-dozmy3lb 126 33 develop develop VB cord-018225-dozmy3lb 126 34 HH HH NNP cord-018225-dozmy3lb 126 35 , , , cord-018225-dozmy3lb 126 36 and and CC cord-018225-dozmy3lb 126 37 23 23 CD cord-018225-dozmy3lb 126 38 died die VBD cord-018225-dozmy3lb 126 39 within within IN cord-018225-dozmy3lb 126 40 24 24 CD cord-018225-dozmy3lb 126 41 hours hour NNS cord-018225-dozmy3lb 126 42 . . . cord-018225-dozmy3lb 127 1 Hepatic hepatic JJ cord-018225-dozmy3lb 127 2 blood blood NN cord-018225-dozmy3lb 127 3 flow flow NN cord-018225-dozmy3lb 127 4 was be VBD cord-018225-dozmy3lb 127 5 measured measure VBN cord-018225-dozmy3lb 127 6 in in IN cord-018225-dozmy3lb 127 7 the the DT cord-018225-dozmy3lb 127 8 20 20 CD cord-018225-dozmy3lb 127 9 patients patient NNS cord-018225-dozmy3lb 127 10 with with IN cord-018225-dozmy3lb 127 11 HH HH NNP cord-018225-dozmy3lb 127 12 , , , cord-018225-dozmy3lb 127 13 and and CC cord-018225-dozmy3lb 127 14 in in IN cord-018225-dozmy3lb 127 15 41 41 CD cord-018225-dozmy3lb 127 16 of of IN cord-018225-dozmy3lb 127 17 the the DT cord-018225-dozmy3lb 127 18 48 48 CD cord-018225-dozmy3lb 127 19 surviving survive VBG cord-018225-dozmy3lb 127 20 patients patient NNS cord-018225-dozmy3lb 127 21 without without IN cord-018225-dozmy3lb 127 22 HH HH NNP cord-018225-dozmy3lb 127 23 , , , cord-018225-dozmy3lb 127 24 using use VBG cord-018225-dozmy3lb 127 25 the the DT cord-018225-dozmy3lb 127 26 method method NN cord-018225-dozmy3lb 127 27 of of IN cord-018225-dozmy3lb 127 28 galactose galactose NN cord-018225-dozmy3lb 127 29 clearance clearance NN cord-018225-dozmy3lb 127 30 at at IN cord-018225-dozmy3lb 127 31 low low JJ cord-018225-dozmy3lb 127 32 concentrations concentration NNS cord-018225-dozmy3lb 127 33 . . . cord-018225-dozmy3lb 128 1 When when WRB cord-018225-dozmy3lb 128 2 compared compare VBN cord-018225-dozmy3lb 128 3 with with IN cord-018225-dozmy3lb 128 4 patients patient NNS cord-018225-dozmy3lb 128 5 who who WP cord-018225-dozmy3lb 128 6 did do VBD cord-018225-dozmy3lb 128 7 not not RB cord-018225-dozmy3lb 128 8 develop develop VB cord-018225-dozmy3lb 128 9 HH HH NNP cord-018225-dozmy3lb 128 10 , , , cord-018225-dozmy3lb 128 11 patients patient NNS cord-018225-dozmy3lb 128 12 with with IN cord-018225-dozmy3lb 128 13 HH HH NNP cord-018225-dozmy3lb 128 14 had have VBD cord-018225-dozmy3lb 128 15 lower low JJR cord-018225-dozmy3lb 128 16 hepatic hepatic JJ cord-018225-dozmy3lb 128 17 blood blood NN cord-018225-dozmy3lb 128 18 flow flow NN cord-018225-dozmy3lb 128 19 ( ( -LRB- cord-018225-dozmy3lb 128 20 867 867 CD cord-018225-dozmy3lb 128 21 ± ± XX cord-018225-dozmy3lb 129 1 377 377 CD cord-018225-dozmy3lb 129 2 ml ml NN cord-018225-dozmy3lb 129 3 / / SYM cord-018225-dozmy3lb 129 4 min min NN cord-018225-dozmy3lb 129 5 vs vs IN cord-018225-dozmy3lb 129 6 1429 1429 CD cord-018225-dozmy3lb 129 7 ± ± CD cord-018225-dozmy3lb 129 8 644 644 CD cord-018225-dozmy3lb 129 9 ml ml NN cord-018225-dozmy3lb 129 10 / / SYM cord-018225-dozmy3lb 129 11 min min NNP cord-018225-dozmy3lb 129 12 ) ) -RRB- cord-018225-dozmy3lb 129 13 , , , cord-018225-dozmy3lb 129 14 higher high JJR cord-018225-dozmy3lb 129 15 central central JJ cord-018225-dozmy3lb 129 16 venous venous JJ cord-018225-dozmy3lb 129 17 pressure pressure NN cord-018225-dozmy3lb 129 18 ( ( -LRB- cord-018225-dozmy3lb 129 19 22.5 22.5 CD cord-018225-dozmy3lb 129 20 cmH cmh NN cord-018225-dozmy3lb 129 21 2 2 CD cord-018225-dozmy3lb 129 22 O o NN cord-018225-dozmy3lb 129 23 vs vs IN cord-018225-dozmy3lb 129 24 14 14 CD cord-018225-dozmy3lb 129 25 cmH cmh NN cord-018225-dozmy3lb 129 26 2 2 CD cord-018225-dozmy3lb 129 27 O O NNP cord-018225-dozmy3lb 129 28 ) ) -RRB- cord-018225-dozmy3lb 129 29 , , , cord-018225-dozmy3lb 129 30 and and CC cord-018225-dozmy3lb 129 31 a a DT cord-018225-dozmy3lb 129 32 trend trend NN cord-018225-dozmy3lb 129 33 toward toward IN cord-018225-dozmy3lb 129 34 lower low JJR cord-018225-dozmy3lb 129 35 cardiac cardiac JJ cord-018225-dozmy3lb 129 36 output output NN cord-018225-dozmy3lb 129 37 ( ( -LRB- cord-018225-dozmy3lb 129 38 3.4 3.4 CD cord-018225-dozmy3lb 129 39 L l NN cord-018225-dozmy3lb 129 40 / / SYM cord-018225-dozmy3lb 129 41 min min NN cord-018225-dozmy3lb 129 42 vs vs IN cord-018225-dozmy3lb 129 43 4.4 4.4 CD cord-018225-dozmy3lb 129 44 L l NN cord-018225-dozmy3lb 129 45 / / SYM cord-018225-dozmy3lb 129 46 min min NN cord-018225-dozmy3lb 129 47 ) ) -RRB- cord-018225-dozmy3lb 129 48 . . . cord-018225-dozmy3lb 130 1 Interestingly interestingly RB cord-018225-dozmy3lb 130 2 , , , cord-018225-dozmy3lb 130 3 only only RB cord-018225-dozmy3lb 130 4 approximately approximately RB cord-018225-dozmy3lb 130 5 50 50 CD cord-018225-dozmy3lb 130 6 % % NN cord-018225-dozmy3lb 130 7 of of IN cord-018225-dozmy3lb 130 8 patients patient NNS cord-018225-dozmy3lb 130 9 in in IN cord-018225-dozmy3lb 130 10 each each DT cord-018225-dozmy3lb 130 11 group group NN cord-018225-dozmy3lb 130 12 had have VBD cord-018225-dozmy3lb 130 13 a a DT cord-018225-dozmy3lb 130 14 systolic systolic JJ cord-018225-dozmy3lb 130 15 arterial arterial JJ cord-018225-dozmy3lb 130 16 pressure pressure NN cord-018225-dozmy3lb 130 17 below below IN cord-018225-dozmy3lb 130 18 90 90 CD cord-018225-dozmy3lb 130 19 mmHg mmHg NNS cord-018225-dozmy3lb 130 20 . . . cord-018225-dozmy3lb 131 1 The the DT cord-018225-dozmy3lb 131 2 overall overall JJ cord-018225-dozmy3lb 131 3 mortality mortality NN cord-018225-dozmy3lb 131 4 was be VBD cord-018225-dozmy3lb 131 5 high high JJ cord-018225-dozmy3lb 131 6 -55 -55 CD cord-018225-dozmy3lb 131 7 % % NN cord-018225-dozmy3lb 131 8 in in IN cord-018225-dozmy3lb 131 9 the the DT cord-018225-dozmy3lb 131 10 HH HH NNP cord-018225-dozmy3lb 131 11 group group NN cord-018225-dozmy3lb 131 12 and and CC cord-018225-dozmy3lb 131 13 46 46 CD cord-018225-dozmy3lb 131 14 % % NN cord-018225-dozmy3lb 131 15 in in IN cord-018225-dozmy3lb 131 16 the the DT cord-018225-dozmy3lb 131 17 group group NN cord-018225-dozmy3lb 131 18 without without IN cord-018225-dozmy3lb 131 19 HH HH NNP cord-018225-dozmy3lb 131 20 . . . cord-018225-dozmy3lb 131 21 _SP cord-018225-dozmy3lb 132 1 The the DT cord-018225-dozmy3lb 132 2 findings finding NNS cord-018225-dozmy3lb 132 3 of of IN cord-018225-dozmy3lb 132 4 this this DT cord-018225-dozmy3lb 132 5 study study NN cord-018225-dozmy3lb 132 6 show show VBP cord-018225-dozmy3lb 132 7 that that IN cord-018225-dozmy3lb 132 8 ischemic ischemic JJ cord-018225-dozmy3lb 132 9 hepatitis hepatitis NN cord-018225-dozmy3lb 132 10 is be VBZ cord-018225-dozmy3lb 132 11 common common JJ cord-018225-dozmy3lb 132 12 in in IN cord-018225-dozmy3lb 132 13 environments environment NNS cord-018225-dozmy3lb 132 14 where where WRB cord-018225-dozmy3lb 132 15 there there EX cord-018225-dozmy3lb 132 16 are be VBP cord-018225-dozmy3lb 132 17 patients patient NNS cord-018225-dozmy3lb 132 18 with with IN cord-018225-dozmy3lb 132 19 low low JJ cord-018225-dozmy3lb 132 20 cardiac cardiac JJ cord-018225-dozmy3lb 132 21 output output NN cord-018225-dozmy3lb 132 22 states state NNS cord-018225-dozmy3lb 132 23 , , , cord-018225-dozmy3lb 132 24 such such JJ cord-018225-dozmy3lb 132 25 as as IN cord-018225-dozmy3lb 132 26 Coronary Coronary NNP cord-018225-dozmy3lb 132 27 Care Care NNP cord-018225-dozmy3lb 132 28 Units Units NNPS cord-018225-dozmy3lb 132 29 and and CC cord-018225-dozmy3lb 132 30 Intensive Intensive NNP cord-018225-dozmy3lb 132 31 Care Care NNP cord-018225-dozmy3lb 132 32 Units Units NNPS cord-018225-dozmy3lb 132 33 . . . cord-018225-dozmy3lb 133 1 The the DT cord-018225-dozmy3lb 133 2 classic classic JJ cord-018225-dozmy3lb 133 3 hemodynamic hemodynamic JJ cord-018225-dozmy3lb 133 4 pattern pattern NN cord-018225-dozmy3lb 133 5 is be VBZ cord-018225-dozmy3lb 133 6 low low JJ cord-018225-dozmy3lb 133 7 cardiac cardiac JJ cord-018225-dozmy3lb 133 8 output output NN cord-018225-dozmy3lb 133 9 ( ( -LRB- cord-018225-dozmy3lb 133 10 resulting result VBG cord-018225-dozmy3lb 133 11 in in IN cord-018225-dozmy3lb 133 12 reduced reduce VBN cord-018225-dozmy3lb 133 13 hepatic hepatic JJ cord-018225-dozmy3lb 133 14 blood blood NN cord-018225-dozmy3lb 133 15 flow flow NN cord-018225-dozmy3lb 133 16 ) ) -RRB- cord-018225-dozmy3lb 133 17 , , , cord-018225-dozmy3lb 133 18 and and CC cord-018225-dozmy3lb 133 19 high high JJ cord-018225-dozmy3lb 133 20 right right JJ cord-018225-dozmy3lb 133 21 atrial atrial JJ cord-018225-dozmy3lb 133 22 pressure pressure NN cord-018225-dozmy3lb 133 23 . . . cord-018225-dozmy3lb 134 1 Hypotension hypotension NN cord-018225-dozmy3lb 134 2 is be VBZ cord-018225-dozmy3lb 134 3 not not RB cord-018225-dozmy3lb 134 4 a a DT cord-018225-dozmy3lb 134 5 prerequisite prerequisite NN cord-018225-dozmy3lb 134 6 . . . cord-018225-dozmy3lb 135 1 The the DT cord-018225-dozmy3lb 135 2 mortality mortality NN cord-018225-dozmy3lb 135 3 rate rate NN cord-018225-dozmy3lb 135 4 is be VBZ cord-018225-dozmy3lb 135 5 > > XX cord-018225-dozmy3lb 135 6 50 50 CD cord-018225-dozmy3lb 135 7 % % NN cord-018225-dozmy3lb 136 1 This this DT cord-018225-dozmy3lb 136 2 is be VBZ cord-018225-dozmy3lb 136 3 the the DT cord-018225-dozmy3lb 136 4 first first JJ cord-018225-dozmy3lb 136 5 prospective prospective JJ cord-018225-dozmy3lb 136 6 study study NN cord-018225-dozmy3lb 136 7 to to TO cord-018225-dozmy3lb 136 8 determine determine VB cord-018225-dozmy3lb 136 9 the the DT cord-018225-dozmy3lb 136 10 incidence incidence NN cord-018225-dozmy3lb 136 11 of of IN cord-018225-dozmy3lb 136 12 ischemic ischemic JJ cord-018225-dozmy3lb 136 13 hepatitis hepatitis NN cord-018225-dozmy3lb 136 14 in in IN cord-018225-dozmy3lb 136 15 patients patient NNS cord-018225-dozmy3lb 136 16 with with IN cord-018225-dozmy3lb 136 17 severe severe JJ cord-018225-dozmy3lb 136 18 cardiac cardiac JJ cord-018225-dozmy3lb 136 19 disease disease NN cord-018225-dozmy3lb 136 20 and and CC cord-018225-dozmy3lb 136 21 low low JJ cord-018225-dozmy3lb 136 22 cardiac cardiac JJ cord-018225-dozmy3lb 136 23 output output NN cord-018225-dozmy3lb 136 24 . . . cord-018225-dozmy3lb 137 1 It -PRON- PRP cord-018225-dozmy3lb 137 2 is be VBZ cord-018225-dozmy3lb 137 3 also also RB cord-018225-dozmy3lb 137 4 by by IN cord-018225-dozmy3lb 137 5 far far RB cord-018225-dozmy3lb 137 6 the the DT cord-018225-dozmy3lb 137 7 most most RBS cord-018225-dozmy3lb 137 8 comprehensive comprehensive JJ cord-018225-dozmy3lb 137 9 study study NN cord-018225-dozmy3lb 137 10 of of IN cord-018225-dozmy3lb 137 11 hemodynamic hemodynamic JJ cord-018225-dozmy3lb 137 12 measurements measurement NNS cord-018225-dozmy3lb 137 13 in in IN cord-018225-dozmy3lb 137 14 patients patient NNS cord-018225-dozmy3lb 137 15 with with IN cord-018225-dozmy3lb 137 16 ischemic ischemic JJ cord-018225-dozmy3lb 137 17 hepatitis hepatitis NN cord-018225-dozmy3lb 137 18 , , , cord-018225-dozmy3lb 137 19 and and CC cord-018225-dozmy3lb 137 20 the the DT cord-018225-dozmy3lb 137 21 only only JJ cord-018225-dozmy3lb 137 22 one one CD cord-018225-dozmy3lb 137 23 to to TO cord-018225-dozmy3lb 137 24 measure measure VB cord-018225-dozmy3lb 137 25 liver liver NN cord-018225-dozmy3lb 137 26 blood blood NN cord-018225-dozmy3lb 137 27 flow flow NN cord-018225-dozmy3lb 137 28 . . . cord-018225-dozmy3lb 138 1 This this DT cord-018225-dozmy3lb 138 2 is be VBZ cord-018225-dozmy3lb 138 3 a a DT cord-018225-dozmy3lb 138 4 large large JJ cord-018225-dozmy3lb 138 5 , , , cord-018225-dozmy3lb 138 6 prospective prospective JJ cord-018225-dozmy3lb 138 7 , , , cord-018225-dozmy3lb 138 8 observational observational JJ cord-018225-dozmy3lb 138 9 study study NN cord-018225-dozmy3lb 138 10 of of IN cord-018225-dozmy3lb 138 11 766 766 CD cord-018225-dozmy3lb 138 12 patients patient NNS cord-018225-dozmy3lb 138 13 admitted admit VBN cord-018225-dozmy3lb 138 14 to to IN cord-018225-dozmy3lb 138 15 a a DT cord-018225-dozmy3lb 138 16 single single JJ cord-018225-dozmy3lb 138 17 intensive intensive JJ cord-018225-dozmy3lb 138 18 care care NN cord-018225-dozmy3lb 138 19 unit unit NN cord-018225-dozmy3lb 138 20 over over IN cord-018225-dozmy3lb 138 21 a a DT cord-018225-dozmy3lb 138 22 1-year 1-year CD cord-018225-dozmy3lb 138 23 period period NN cord-018225-dozmy3lb 138 24 . . . cord-018225-dozmy3lb 139 1 Exclusion exclusion NN cord-018225-dozmy3lb 139 2 of of IN cord-018225-dozmy3lb 139 3 the the DT cord-018225-dozmy3lb 139 4 23 23 CD cord-018225-dozmy3lb 139 5 patients patient NNS cord-018225-dozmy3lb 139 6 who who WP cord-018225-dozmy3lb 139 7 died die VBD cord-018225-dozmy3lb 139 8 within within IN cord-018225-dozmy3lb 139 9 24 24 CD cord-018225-dozmy3lb 139 10 hours hour NNS cord-018225-dozmy3lb 139 11 of of IN cord-018225-dozmy3lb 139 12 the the DT cord-018225-dozmy3lb 139 13 episode episode NN cord-018225-dozmy3lb 139 14 of of IN cord-018225-dozmy3lb 139 15 low low JJ cord-018225-dozmy3lb 139 16 cardiac cardiac JJ cord-018225-dozmy3lb 139 17 output output NN cord-018225-dozmy3lb 139 18 , , , cord-018225-dozmy3lb 139 19 before before IN cord-018225-dozmy3lb 139 20 measurements measurement NNS cord-018225-dozmy3lb 139 21 of of IN cord-018225-dozmy3lb 139 22 hepatic hepatic JJ cord-018225-dozmy3lb 139 23 blood blood NN cord-018225-dozmy3lb 139 24 flow flow NN cord-018225-dozmy3lb 139 25 had have VBD cord-018225-dozmy3lb 139 26 been be VBN cord-018225-dozmy3lb 139 27 made make VBN cord-018225-dozmy3lb 139 28 , , , cord-018225-dozmy3lb 139 29 may may MD cord-018225-dozmy3lb 139 30 have have VB cord-018225-dozmy3lb 139 31 altered alter VBN cord-018225-dozmy3lb 139 32 the the DT cord-018225-dozmy3lb 139 33 findings finding NNS cord-018225-dozmy3lb 139 34 , , , cord-018225-dozmy3lb 139 35 particularly particularly RB cord-018225-dozmy3lb 139 36 regarding regard VBG cord-018225-dozmy3lb 139 37 the the DT cord-018225-dozmy3lb 139 38 incidence incidence NN cord-018225-dozmy3lb 139 39 of of IN cord-018225-dozmy3lb 139 40 ischemic ischemic JJ cord-018225-dozmy3lb 139 41 hepatitis hepatitis NN cord-018225-dozmy3lb 139 42 . . . cord-018225-dozmy3lb 140 1 The the DT cord-018225-dozmy3lb 140 2 validity validity NN cord-018225-dozmy3lb 140 3 of of IN cord-018225-dozmy3lb 140 4 the the DT cord-018225-dozmy3lb 140 5 hepatic hepatic JJ cord-018225-dozmy3lb 140 6 blood blood NN cord-018225-dozmy3lb 140 7 flow flow NN cord-018225-dozmy3lb 140 8 measurements measurement NNS cord-018225-dozmy3lb 140 9 themselves -PRON- PRP cord-018225-dozmy3lb 140 10 are be VBP cord-018225-dozmy3lb 140 11 open open JJ cord-018225-dozmy3lb 140 12 to to IN cord-018225-dozmy3lb 140 13 some some DT cord-018225-dozmy3lb 140 14 dispute dispute NN cord-018225-dozmy3lb 140 15 -firstly -firstly RB cord-018225-dozmy3lb 140 16 because because IN cord-018225-dozmy3lb 140 17 of of IN cord-018225-dozmy3lb 140 18 the the DT cord-018225-dozmy3lb 140 19 use use NN cord-018225-dozmy3lb 140 20 of of IN cord-018225-dozmy3lb 140 21 galactose galactose NN cord-018225-dozmy3lb 140 22 clearance clearance NN cord-018225-dozmy3lb 140 23 rather rather RB cord-018225-dozmy3lb 140 24 than than IN cord-018225-dozmy3lb 140 25 indocyanine indocyanine NNP cord-018225-dozmy3lb 140 26 green green JJ cord-018225-dozmy3lb 140 27 clearance clearance NN cord-018225-dozmy3lb 140 28 , , , cord-018225-dozmy3lb 140 29 and and CC cord-018225-dozmy3lb 140 30 secondly secondly RB cord-018225-dozmy3lb 140 31 because because IN cord-018225-dozmy3lb 140 32 they -PRON- PRP cord-018225-dozmy3lb 140 33 were be VBD cord-018225-dozmy3lb 140 34 performed perform VBN cord-018225-dozmy3lb 140 35 subsequent subsequent JJ cord-018225-dozmy3lb 140 36 to to IN cord-018225-dozmy3lb 140 37 the the DT cord-018225-dozmy3lb 140 38 episode episode NN cord-018225-dozmy3lb 140 39 of of IN cord-018225-dozmy3lb 140 40 low low JJ cord-018225-dozmy3lb 140 41 cardiac cardiac JJ cord-018225-dozmy3lb 140 42 output output NN cord-018225-dozmy3lb 140 43 , , , cord-018225-dozmy3lb 140 44 and and CC cord-018225-dozmy3lb 140 45 therefore therefore RB cord-018225-dozmy3lb 140 46 may may MD cord-018225-dozmy3lb 140 47 not not RB cord-018225-dozmy3lb 140 48 reflect reflect VB cord-018225-dozmy3lb 140 49 the the DT cord-018225-dozmy3lb 140 50 hemodynamic hemodynamic JJ cord-018225-dozmy3lb 140 51 state state NN cord-018225-dozmy3lb 140 52 at at IN cord-018225-dozmy3lb 140 53 that that DT cord-018225-dozmy3lb 140 54 time time NN cord-018225-dozmy3lb 140 55 . . . cord-018225-dozmy3lb 141 1 Ischemic ischemic JJ cord-018225-dozmy3lb 141 2 hepatitis hepatitis NN cord-018225-dozmy3lb 141 3 occurs occur VBZ cord-018225-dozmy3lb 141 4 in in IN cord-018225-dozmy3lb 141 5 up up IN cord-018225-dozmy3lb 141 6 to to TO cord-018225-dozmy3lb 141 7 5 5 CD cord-018225-dozmy3lb 141 8 % % NN cord-018225-dozmy3lb 141 9 of of IN cord-018225-dozmy3lb 141 10 admissions admission NNS cord-018225-dozmy3lb 141 11 to to IN cord-018225-dozmy3lb 141 12 Intensive Intensive NNP cord-018225-dozmy3lb 141 13 Care Care NNP cord-018225-dozmy3lb 141 14 Units Units NNPS cord-018225-dozmy3lb 141 15 and and CC cord-018225-dozmy3lb 141 16 Coronary Coronary NNP cord-018225-dozmy3lb 141 17 Care Care NNP cord-018225-dozmy3lb 141 18 Units Units NNPS cord-018225-dozmy3lb 141 19 , , , cord-018225-dozmy3lb 141 20 and and CC cord-018225-dozmy3lb 141 21 is be VBZ cord-018225-dozmy3lb 141 22 consequently consequently RB cord-018225-dozmy3lb 141 23 more more RBR cord-018225-dozmy3lb 141 24 common common JJ cord-018225-dozmy3lb 141 25 than than IN cord-018225-dozmy3lb 141 26 a a DT cord-018225-dozmy3lb 141 27 number number NN cord-018225-dozmy3lb 141 28 of of IN cord-018225-dozmy3lb 141 29 other other JJ cord-018225-dozmy3lb 141 30 conditions condition NNS cord-018225-dozmy3lb 141 31 that that WDT cord-018225-dozmy3lb 141 32 have have VBP cord-018225-dozmy3lb 141 33 attracted attract VBN cord-018225-dozmy3lb 141 34 massive massive JJ cord-018225-dozmy3lb 141 35 research research NN cord-018225-dozmy3lb 141 36 interest interest NN cord-018225-dozmy3lb 141 37 . . . cord-018225-dozmy3lb 142 1 This this DT cord-018225-dozmy3lb 142 2 paper paper NN cord-018225-dozmy3lb 142 3 describes describe VBZ cord-018225-dozmy3lb 142 4 the the DT cord-018225-dozmy3lb 142 5 clinical clinical JJ cord-018225-dozmy3lb 142 6 setting setting NN cord-018225-dozmy3lb 142 7 , , , cord-018225-dozmy3lb 142 8 hemodynamic hemodynamic JJ cord-018225-dozmy3lb 142 9 characteristics characteristic NNS cord-018225-dozmy3lb 142 10 , , , cord-018225-dozmy3lb 142 11 and and CC cord-018225-dozmy3lb 142 12 outcome outcome NN cord-018225-dozmy3lb 142 13 of of IN cord-018225-dozmy3lb 142 14 ischemic ischemic JJ cord-018225-dozmy3lb 142 15 hepatitis hepatitis NN cord-018225-dozmy3lb 142 16 , , , cord-018225-dozmy3lb 142 17 and and CC cord-018225-dozmy3lb 142 18 consequently consequently RB cord-018225-dozmy3lb 142 19 makes make VBZ cord-018225-dozmy3lb 142 20 a a DT cord-018225-dozmy3lb 142 21 major major JJ cord-018225-dozmy3lb 142 22 contribution contribution NN cord-018225-dozmy3lb 142 23 to to IN cord-018225-dozmy3lb 142 24 the the DT cord-018225-dozmy3lb 142 25 body body NN cord-018225-dozmy3lb 142 26 of of IN cord-018225-dozmy3lb 142 27 knowledge knowledge NN cord-018225-dozmy3lb 142 28 on on IN cord-018225-dozmy3lb 142 29 the the DT cord-018225-dozmy3lb 142 30 subject subject NN cord-018225-dozmy3lb 142 31 . . . cord-018225-dozmy3lb 143 1 Ischemic ischemic JJ cord-018225-dozmy3lb 143 2 hepatitis hepatitis NN cord-018225-dozmy3lb 143 3 is be VBZ cord-018225-dozmy3lb 143 4 not not RB cord-018225-dozmy3lb 143 5 a a DT cord-018225-dozmy3lb 143 6 rare rare JJ cord-018225-dozmy3lb 143 7 hepatic hepatic JJ cord-018225-dozmy3lb 143 8 disorder disorder NN cord-018225-dozmy3lb 143 9 , , , cord-018225-dozmy3lb 143 10 but but CC cord-018225-dozmy3lb 143 11 rather rather RB cord-018225-dozmy3lb 143 12 it -PRON- PRP cord-018225-dozmy3lb 143 13 is be VBZ cord-018225-dozmy3lb 143 14 a a DT cord-018225-dozmy3lb 143 15 circulatory circulatory JJ cord-018225-dozmy3lb 143 16 disorder disorder NN cord-018225-dozmy3lb 143 17 , , , cord-018225-dozmy3lb 143 18 and and CC cord-018225-dozmy3lb 143 19 therefore therefore RB cord-018225-dozmy3lb 143 20 of of IN cord-018225-dozmy3lb 143 21 great great JJ cord-018225-dozmy3lb 143 22 relevance relevance NN cord-018225-dozmy3lb 143 23 to to IN cord-018225-dozmy3lb 143 24 intensive intensive JJ cord-018225-dozmy3lb 143 25 care care NN cord-018225-dozmy3lb 143 26 medicine medicine NN cord-018225-dozmy3lb 143 27 . . . cord-018225-dozmy3lb 144 1 Abstract Abstract NNP cord-018225-dozmy3lb 144 2 A a DT cord-018225-dozmy3lb 144 3 novel novel JJ cord-018225-dozmy3lb 144 4 quantitative quantitative JJ cord-018225-dozmy3lb 144 5 liver liver NN cord-018225-dozmy3lb 144 6 function function NN cord-018225-dozmy3lb 144 7 test test NN cord-018225-dozmy3lb 144 8 is be VBZ cord-018225-dozmy3lb 144 9 described describe VBN cord-018225-dozmy3lb 144 10 which which WDT cord-018225-dozmy3lb 144 11 is be VBZ cord-018225-dozmy3lb 144 12 based base VBN cord-018225-dozmy3lb 144 13 on on IN cord-018225-dozmy3lb 144 14 monoethylglycinexylidide monoethylglycinexylidide NN cord-018225-dozmy3lb 144 15 ( ( -LRB- cord-018225-dozmy3lb 144 16 MEGX MEGX NNP cord-018225-dozmy3lb 144 17 ) ) -RRB- cord-018225-dozmy3lb 144 18 formation formation NN cord-018225-dozmy3lb 144 19 after after IN cord-018225-dozmy3lb 144 20 lidocaine lidocaine NN cord-018225-dozmy3lb 144 21 bolus bolus NN cord-018225-dozmy3lb 144 22 injection injection NN cord-018225-dozmy3lb 144 23 . . . cord-018225-dozmy3lb 145 1 Following follow VBG cord-018225-dozmy3lb 145 2 the the DT cord-018225-dozmy3lb 145 3 administration administration NN cord-018225-dozmy3lb 145 4 of of IN cord-018225-dozmy3lb 145 5 small small JJ cord-018225-dozmy3lb 145 6 single single JJ cord-018225-dozmy3lb 145 7 doses dose NNS cord-018225-dozmy3lb 145 8 of of IN cord-018225-dozmy3lb 145 9 lidocaine lidocaine NN cord-018225-dozmy3lb 145 10 hydrochloride hydrochloride NN cord-018225-dozmy3lb 145 11 ( ( -LRB- cord-018225-dozmy3lb 145 12 1 1 CD cord-018225-dozmy3lb 145 13 mg mg NNP cord-018225-dozmy3lb 145 14 / / SYM cord-018225-dozmy3lb 145 15 kg kg NNP cord-018225-dozmy3lb 145 16 ) ) -RRB- cord-018225-dozmy3lb 145 17 , , , cord-018225-dozmy3lb 145 18 monoethylglycinexylidide monoethylglycinexylidide NN cord-018225-dozmy3lb 145 19 serum serum NN cord-018225-dozmy3lb 145 20 concentration concentration NN cord-018225-dozmy3lb 145 21 - - HYPH cord-018225-dozmy3lb 145 22 time time NN cord-018225-dozmy3lb 145 23 curves curve NNS cord-018225-dozmy3lb 145 24 were be VBD cord-018225-dozmy3lb 145 25 determined determine VBN cord-018225-dozmy3lb 145 26 by by IN cord-018225-dozmy3lb 145 27 a a DT cord-018225-dozmy3lb 145 28 novel novel NN cord-018225-dozmy3lb 145 29 , , , cord-018225-dozmy3lb 145 30 highly highly RB cord-018225-dozmy3lb 145 31 sensitive sensitive JJ cord-018225-dozmy3lb 145 32 fluorescence fluorescence NN cord-018225-dozmy3lb 145 33 polarization polarization NN cord-018225-dozmy3lb 145 34 immunoassay immunoassay NN cord-018225-dozmy3lb 145 35 ( ( -LRB- cord-018225-dozmy3lb 145 36 FPIA FPIA NNP cord-018225-dozmy3lb 145 37 ) ) -RRB- cord-018225-dozmy3lb 145 38 in in IN cord-018225-dozmy3lb 145 39 healthy healthy JJ cord-018225-dozmy3lb 145 40 volunteers volunteer NNS cord-018225-dozmy3lb 145 41 , , , cord-018225-dozmy3lb 145 42 liver liver NN cord-018225-dozmy3lb 145 43 donors donor NNS cord-018225-dozmy3lb 145 44 , , , cord-018225-dozmy3lb 145 45 and and CC cord-018225-dozmy3lb 145 46 patients patient NNS cord-018225-dozmy3lb 145 47 with with IN cord-018225-dozmy3lb 145 48 liver liver NN cord-018225-dozmy3lb 145 49 cirrhosis cirrhosis NN cord-018225-dozmy3lb 145 50 . . . cord-018225-dozmy3lb 146 1 The the DT cord-018225-dozmy3lb 146 2 FPIA FPIA NNP cord-018225-dozmy3lb 146 3 allowed allow VBD cord-018225-dozmy3lb 146 4 rapid rapid JJ cord-018225-dozmy3lb 146 5 and and CC cord-018225-dozmy3lb 146 6 reliable reliable JJ cord-018225-dozmy3lb 146 7 monoethylglycinexylidide monoethylglycinexylidide JJ cord-018225-dozmy3lb 146 8 determinations determination NNS cord-018225-dozmy3lb 146 9 in in IN cord-018225-dozmy3lb 146 10 serum serum NN cord-018225-dozmy3lb 146 11 and and CC cord-018225-dozmy3lb 146 12 urine urine NN cord-018225-dozmy3lb 146 13 ( ( -LRB- cord-018225-dozmy3lb 146 14 between between IN cord-018225-dozmy3lb 146 15 - - HYPH cord-018225-dozmy3lb 146 16 days day NNS cord-018225-dozmy3lb 146 17 coefficient coefficient NN cord-018225-dozmy3lb 146 18 of of IN cord-018225-dozmy3lb 146 19 variation variation NN cord-018225-dozmy3lb 146 20 : : : cord-018225-dozmy3lb 146 21 < < XX cord-018225-dozmy3lb 146 22 10.3 10.3 CD cord-018225-dozmy3lb 146 23 % % NN cord-018225-dozmy3lb 146 24 , , , cord-018225-dozmy3lb 146 25 recovery recovery NN cord-018225-dozmy3lb 146 26 : : : cord-018225-dozmy3lb 146 27 80 80 CD cord-018225-dozmy3lb 146 28 - - SYM cord-018225-dozmy3lb 146 29 113 113 CD cord-018225-dozmy3lb 146 30 % % NN cord-018225-dozmy3lb 146 31 ) ) -RRB- cord-018225-dozmy3lb 146 32 . . . cord-018225-dozmy3lb 147 1 Monoethylglycinexylidide Monoethylglycinexylidide NNP cord-018225-dozmy3lb 147 2 concentrations concentration NNS cord-018225-dozmy3lb 147 3 measured measure VBN cord-018225-dozmy3lb 147 4 by by IN cord-018225-dozmy3lb 147 5 FPIA FPIA NNP cord-018225-dozmy3lb 147 6 in in IN cord-018225-dozmy3lb 147 7 32 32 CD cord-018225-dozmy3lb 147 8 serum serum NN cord-018225-dozmy3lb 147 9 samples sample NNS cord-018225-dozmy3lb 147 10 from from IN cord-018225-dozmy3lb 147 11 patients patient NNS cord-018225-dozmy3lb 147 12 correlated correlate VBN cord-018225-dozmy3lb 147 13 well well RB cord-018225-dozmy3lb 147 14 with with IN cord-018225-dozmy3lb 147 15 those those DT cord-018225-dozmy3lb 147 16 determined determine VBN cord-018225-dozmy3lb 147 17 by by IN cord-018225-dozmy3lb 147 18 HPLC HPLC NNP cord-018225-dozmy3lb 147 19 . . . cord-018225-dozmy3lb 148 1 The the DT cord-018225-dozmy3lb 148 2 monoethylglycinexylidide monoethylglycinexylidide JJ cord-018225-dozmy3lb 148 3 concentration concentration NN cord-018225-dozmy3lb 148 4 in in IN cord-018225-dozmy3lb 148 5 serum serum NN cord-018225-dozmy3lb 148 6 determined determine VBD cord-018225-dozmy3lb 148 7 15 15 CD cord-018225-dozmy3lb 148 8 minute minute NN cord-018225-dozmy3lb 148 9 after after IN cord-018225-dozmy3lb 148 10 a a DT cord-018225-dozmy3lb 148 11 lidocaine lidocaine NN cord-018225-dozmy3lb 148 12 bolus bolus NN cord-018225-dozmy3lb 148 13 injection injection NN cord-018225-dozmy3lb 148 14 proved prove VBD cord-018225-dozmy3lb 148 15 to to TO cord-018225-dozmy3lb 148 16 be be VB cord-018225-dozmy3lb 148 17 a a DT cord-018225-dozmy3lb 148 18 highly highly RB cord-018225-dozmy3lb 148 19 sensitive sensitive JJ cord-018225-dozmy3lb 148 20 and and CC cord-018225-dozmy3lb 148 21 specific specific JJ cord-018225-dozmy3lb 148 22 indicator indicator NN cord-018225-dozmy3lb 148 23 of of IN cord-018225-dozmy3lb 148 24 hepatic hepatic JJ cord-018225-dozmy3lb 148 25 dysfunction dysfunction NN cord-018225-dozmy3lb 148 26 . . . cord-018225-dozmy3lb 149 1 Average average JJ cord-018225-dozmy3lb 149 2 monoethylglycinexylidide monoethylglycinexylidide NN cord-018225-dozmy3lb 149 3 concentrations concentration NNS cord-018225-dozmy3lb 149 4 in in IN cord-018225-dozmy3lb 149 5 serum serum NN cord-018225-dozmy3lb 149 6 obtained obtain VBD cord-018225-dozmy3lb 149 7 15 15 CD cord-018225-dozmy3lb 149 8 minute minute NN cord-018225-dozmy3lb 149 9 after after IN cord-018225-dozmy3lb 149 10 lidocaine lidocaine NN cord-018225-dozmy3lb 149 11 injection injection NN cord-018225-dozmy3lb 149 12 were be VBD cord-018225-dozmy3lb 149 13 substantially substantially RB cord-018225-dozmy3lb 149 14 lower low JJR cord-018225-dozmy3lb 149 15 in in IN cord-018225-dozmy3lb 149 16 patients patient NNS cord-018225-dozmy3lb 149 17 with with IN cord-018225-dozmy3lb 149 18 liver liver NN cord-018225-dozmy3lb 149 19 cirrhosis cirrhosis NN cord-018225-dozmy3lb 149 20 than than IN cord-018225-dozmy3lb 149 21 in in IN cord-018225-dozmy3lb 149 22 healthy healthy JJ cord-018225-dozmy3lb 149 23 volunteers volunteer NNS cord-018225-dozmy3lb 149 24 . . . cord-018225-dozmy3lb 150 1 The the DT cord-018225-dozmy3lb 150 2 average average JJ cord-018225-dozmy3lb 150 3 monoethylglycinexylidide monoethylglycinexylidide NN cord-018225-dozmy3lb 150 4 concentrations concentration NNS cord-018225-dozmy3lb 150 5 in in IN cord-018225-dozmy3lb 150 6 serum serum NN cord-018225-dozmy3lb 150 7 were be VBD cord-018225-dozmy3lb 150 8 also also RB cord-018225-dozmy3lb 150 9 substantially substantially RB cord-018225-dozmy3lb 150 10 lower low JJR cord-018225-dozmy3lb 150 11 in in IN cord-018225-dozmy3lb 150 12 liver liver NN cord-018225-dozmy3lb 150 13 donors donor NNS cord-018225-dozmy3lb 150 14 with with IN cord-018225-dozmy3lb 150 15 ballooning ballooning NN cord-018225-dozmy3lb 150 16 or or CC cord-018225-dozmy3lb 150 17 fatty fatty JJ cord-018225-dozmy3lb 150 18 changes change NNS cord-018225-dozmy3lb 150 19 of of IN cord-018225-dozmy3lb 150 20 hepatocytes hepatocyte NNS cord-018225-dozmy3lb 150 21 than than IN cord-018225-dozmy3lb 150 22 in in IN cord-018225-dozmy3lb 150 23 donors donor NNS cord-018225-dozmy3lb 150 24 without without IN cord-018225-dozmy3lb 150 25 relevant relevant JJ cord-018225-dozmy3lb 150 26 alterations alteration NNS cord-018225-dozmy3lb 150 27 of of IN cord-018225-dozmy3lb 150 28 liver liver NN cord-018225-dozmy3lb 150 29 histology histology NN cord-018225-dozmy3lb 150 30 . . . cord-018225-dozmy3lb 151 1 By by IN cord-018225-dozmy3lb 151 2 means mean NNS cord-018225-dozmy3lb 151 3 of of IN cord-018225-dozmy3lb 151 4 monoethylglycinexylidide monoethylglycinexylidide JJ cord-018225-dozmy3lb 151 5 formation formation NN cord-018225-dozmy3lb 151 6 in in IN cord-018225-dozmy3lb 151 7 the the DT cord-018225-dozmy3lb 151 8 liver liver NN cord-018225-dozmy3lb 151 9 donors donor NNS cord-018225-dozmy3lb 151 10 , , , cord-018225-dozmy3lb 151 11 primary primary JJ cord-018225-dozmy3lb 151 12 function function NN cord-018225-dozmy3lb 151 13 of of IN cord-018225-dozmy3lb 151 14 the the DT cord-018225-dozmy3lb 151 15 transplanted transplanted JJ cord-018225-dozmy3lb 151 16 liver liver NN cord-018225-dozmy3lb 151 17 was be VBD cord-018225-dozmy3lb 151 18 correctly correctly RB cord-018225-dozmy3lb 151 19 predicted predict VBN cord-018225-dozmy3lb 151 20 in in IN cord-018225-dozmy3lb 151 21 32/37 32/37 CD cord-018225-dozmy3lb 151 22 cases case NNS cord-018225-dozmy3lb 151 23 , , , cord-018225-dozmy3lb 151 24 and and CC cord-018225-dozmy3lb 151 25 initial initial JJ cord-018225-dozmy3lb 151 26 non non JJ cord-018225-dozmy3lb 151 27 - - JJ cord-018225-dozmy3lb 151 28 function function NN cord-018225-dozmy3lb 151 29 in in IN cord-018225-dozmy3lb 151 30 4/6 4/6 CD cord-018225-dozmy3lb 151 31 cases case NNS cord-018225-dozmy3lb 151 32 . . . cord-018225-dozmy3lb 152 1 Monoethylglycinexylidide Monoethylglycinexylidide NNP cord-018225-dozmy3lb 152 2 ( ( -LRB- cord-018225-dozmy3lb 152 3 MEGX MEGX NNP cord-018225-dozmy3lb 152 4 ) ) -RRB- cord-018225-dozmy3lb 152 5 is be VBZ cord-018225-dozmy3lb 152 6 the the DT cord-018225-dozmy3lb 152 7 first first JJ cord-018225-dozmy3lb 152 8 metabolite metabolite NN cord-018225-dozmy3lb 152 9 of of IN cord-018225-dozmy3lb 152 10 lignocaine lignocaine NN cord-018225-dozmy3lb 152 11 formed form VBN cord-018225-dozmy3lb 152 12 by by IN cord-018225-dozmy3lb 152 13 oxidative oxidative JJ cord-018225-dozmy3lb 152 14 de de NN cord-018225-dozmy3lb 152 15 - - NN cord-018225-dozmy3lb 152 16 ethylation ethylation NN cord-018225-dozmy3lb 152 17 by by IN cord-018225-dozmy3lb 152 18 the the DT cord-018225-dozmy3lb 152 19 hepatic hepatic JJ cord-018225-dozmy3lb 152 20 cytochrome cytochrome NN cord-018225-dozmy3lb 152 21 P-450 P-450 VBD cord-018225-dozmy3lb 152 22 system system NN cord-018225-dozmy3lb 152 23 . . . cord-018225-dozmy3lb 153 1 In in IN cord-018225-dozmy3lb 153 2 this this DT cord-018225-dozmy3lb 153 3 study study NN cord-018225-dozmy3lb 153 4 , , , cord-018225-dozmy3lb 153 5 the the DT cord-018225-dozmy3lb 153 6 appearance appearance NN cord-018225-dozmy3lb 153 7 of of IN cord-018225-dozmy3lb 153 8 MEGX MEGX NNP cord-018225-dozmy3lb 153 9 measured measure VBN cord-018225-dozmy3lb 153 10 by by IN cord-018225-dozmy3lb 153 11 a a DT cord-018225-dozmy3lb 153 12 fluorescence fluorescence NN cord-018225-dozmy3lb 153 13 polarization polarization NN cord-018225-dozmy3lb 153 14 immunoassay immunoassay JJ cord-018225-dozmy3lb 153 15 after after IN cord-018225-dozmy3lb 153 16 a a DT cord-018225-dozmy3lb 153 17 test test NN cord-018225-dozmy3lb 153 18 dose dose NN cord-018225-dozmy3lb 153 19 of of IN cord-018225-dozmy3lb 153 20 intravenous intravenous JJ cord-018225-dozmy3lb 153 21 lignocaine lignocaine NN cord-018225-dozmy3lb 153 22 was be VBD cord-018225-dozmy3lb 153 23 investigated investigate VBN cord-018225-dozmy3lb 153 24 as as IN cord-018225-dozmy3lb 153 25 a a DT cord-018225-dozmy3lb 153 26 liver liver NN cord-018225-dozmy3lb 153 27 function function NN cord-018225-dozmy3lb 153 28 test test NN cord-018225-dozmy3lb 153 29 . . . cord-018225-dozmy3lb 154 1 The the DT cord-018225-dozmy3lb 154 2 findings finding NNS cord-018225-dozmy3lb 154 3 showed show VBD cord-018225-dozmy3lb 154 4 that that IN cord-018225-dozmy3lb 154 5 there there EX cord-018225-dozmy3lb 154 6 was be VBD cord-018225-dozmy3lb 154 7 a a DT cord-018225-dozmy3lb 154 8 satisfactory satisfactory JJ cord-018225-dozmy3lb 154 9 correlation correlation NN cord-018225-dozmy3lb 154 10 between between IN cord-018225-dozmy3lb 154 11 the the DT cord-018225-dozmy3lb 154 12 measurement measurement NN cord-018225-dozmy3lb 154 13 of of IN cord-018225-dozmy3lb 154 14 MEGX MEGX NNP cord-018225-dozmy3lb 154 15 by by IN cord-018225-dozmy3lb 154 16 the the DT cord-018225-dozmy3lb 154 17 novel novel JJ cord-018225-dozmy3lb 154 18 fluorescence fluorescence NN cord-018225-dozmy3lb 154 19 polarization polarization NN cord-018225-dozmy3lb 154 20 immunoassay immunoassay JJ cord-018225-dozmy3lb 154 21 and and CC cord-018225-dozmy3lb 154 22 by by IN cord-018225-dozmy3lb 154 23 high high JJ cord-018225-dozmy3lb 154 24 performance performance NN cord-018225-dozmy3lb 154 25 liquid liquid NN cord-018225-dozmy3lb 154 26 chromatography chromatography NN cord-018225-dozmy3lb 154 27 . . . cord-018225-dozmy3lb 155 1 The the DT cord-018225-dozmy3lb 155 2 formation formation NN cord-018225-dozmy3lb 155 3 and and CC cord-018225-dozmy3lb 155 4 elimination elimination NN cord-018225-dozmy3lb 155 5 kinetics kinetic NNS cord-018225-dozmy3lb 155 6 of of IN cord-018225-dozmy3lb 155 7 MEGX MEGX NNP cord-018225-dozmy3lb 155 8 were be VBD cord-018225-dozmy3lb 155 9 investigated investigate VBN cord-018225-dozmy3lb 155 10 for for IN cord-018225-dozmy3lb 155 11 healthy healthy JJ cord-018225-dozmy3lb 155 12 volunteers volunteer NNS cord-018225-dozmy3lb 155 13 , , , cord-018225-dozmy3lb 155 14 patients patient NNS cord-018225-dozmy3lb 155 15 with with IN cord-018225-dozmy3lb 155 16 histologically histologically RB cord-018225-dozmy3lb 155 17 confirmed confirm VBN cord-018225-dozmy3lb 155 18 liver liver NN cord-018225-dozmy3lb 155 19 cirrhosis cirrhosis NN cord-018225-dozmy3lb 155 20 , , , cord-018225-dozmy3lb 155 21 and and CC cord-018225-dozmy3lb 155 22 liver liver NN cord-018225-dozmy3lb 155 23 donors donor NNS cord-018225-dozmy3lb 155 24 after after IN cord-018225-dozmy3lb 155 25 a a DT cord-018225-dozmy3lb 155 26 single single JJ cord-018225-dozmy3lb 155 27 intravenous intravenous JJ cord-018225-dozmy3lb 155 28 bolus bolus NN cord-018225-dozmy3lb 155 29 injection injection NN cord-018225-dozmy3lb 155 30 of of IN cord-018225-dozmy3lb 155 31 lignocaine lignocaine NNP cord-018225-dozmy3lb 155 32 ( ( -LRB- cord-018225-dozmy3lb 155 33 1 1 CD cord-018225-dozmy3lb 155 34 mg mg NNP cord-018225-dozmy3lb 155 35 / / SYM cord-018225-dozmy3lb 155 36 kg kg NNP cord-018225-dozmy3lb 155 37 ) ) -RRB- cord-018225-dozmy3lb 155 38 . . . cord-018225-dozmy3lb 156 1 In in IN cord-018225-dozmy3lb 156 2 healthy healthy JJ cord-018225-dozmy3lb 156 3 volunteers volunteer NNS cord-018225-dozmy3lb 156 4 , , , cord-018225-dozmy3lb 156 5 the the DT cord-018225-dozmy3lb 156 6 peak peak NN cord-018225-dozmy3lb 156 7 MEGX MEGX NNP cord-018225-dozmy3lb 156 8 concentration concentration NN cord-018225-dozmy3lb 156 9 occurred occur VBD cord-018225-dozmy3lb 156 10 15 15 CD cord-018225-dozmy3lb 156 11 minutes minute NNS cord-018225-dozmy3lb 156 12 after after IN cord-018225-dozmy3lb 156 13 the the DT cord-018225-dozmy3lb 156 14 bolus bolus NN cord-018225-dozmy3lb 156 15 of of IN cord-018225-dozmy3lb 156 16 lignocaine lignocaine NN cord-018225-dozmy3lb 156 17 , , , cord-018225-dozmy3lb 156 18 whereas whereas IN cord-018225-dozmy3lb 156 19 in in IN cord-018225-dozmy3lb 156 20 patients patient NNS cord-018225-dozmy3lb 156 21 with with IN cord-018225-dozmy3lb 156 22 cirrhosis cirrhosis NN cord-018225-dozmy3lb 156 23 , , , cord-018225-dozmy3lb 156 24 its -PRON- PRP$ cord-018225-dozmy3lb 156 25 rate rate NN cord-018225-dozmy3lb 156 26 of of IN cord-018225-dozmy3lb 156 27 formation formation NN cord-018225-dozmy3lb 156 28 was be VBD cord-018225-dozmy3lb 156 29 markedly markedly RB cord-018225-dozmy3lb 156 30 decreased decrease VBN cord-018225-dozmy3lb 156 31 , , , cord-018225-dozmy3lb 156 32 and and CC cord-018225-dozmy3lb 156 33 maximum maximum JJ cord-018225-dozmy3lb 156 34 concentrations concentration NNS cord-018225-dozmy3lb 156 35 were be VBD cord-018225-dozmy3lb 156 36 observed observe VBN cord-018225-dozmy3lb 156 37 at at IN cord-018225-dozmy3lb 156 38 about about RB cord-018225-dozmy3lb 156 39 4 4 CD cord-018225-dozmy3lb 156 40 hours hour NNS cord-018225-dozmy3lb 156 41 . . . cord-018225-dozmy3lb 157 1 In in IN cord-018225-dozmy3lb 157 2 liver liver NN cord-018225-dozmy3lb 157 3 donors donor NNS cord-018225-dozmy3lb 157 4 the the DT cord-018225-dozmy3lb 157 5 15-minute 15-minute JJ cord-018225-dozmy3lb 157 6 MEGX MEGX NNP cord-018225-dozmy3lb 157 7 concentration concentration NN cord-018225-dozmy3lb 157 8 was be VBD cord-018225-dozmy3lb 157 9 lower low JJR cord-018225-dozmy3lb 157 10 in in IN cord-018225-dozmy3lb 157 11 donors donor NNS cord-018225-dozmy3lb 157 12 , , , cord-018225-dozmy3lb 157 13 with with IN cord-018225-dozmy3lb 157 14 altered alter VBN cord-018225-dozmy3lb 157 15 liver liver NN cord-018225-dozmy3lb 157 16 histology histology NN cord-018225-dozmy3lb 157 17 than than IN cord-018225-dozmy3lb 157 18 in in IN cord-018225-dozmy3lb 157 19 those those DT cord-018225-dozmy3lb 157 20 with with IN cord-018225-dozmy3lb 157 21 normal normal JJ cord-018225-dozmy3lb 157 22 histology histology NN cord-018225-dozmy3lb 157 23 . . . cord-018225-dozmy3lb 158 1 Patients patient NNS cord-018225-dozmy3lb 158 2 with with IN cord-018225-dozmy3lb 158 3 cirrhosis cirrhosis NN cord-018225-dozmy3lb 158 4 had have VBD cord-018225-dozmy3lb 158 5 the the DT cord-018225-dozmy3lb 158 6 lowest low JJS cord-018225-dozmy3lb 158 7 15-minute 15-minute JJ cord-018225-dozmy3lb 158 8 MEGX MEGX NNP cord-018225-dozmy3lb 158 9 concentration concentration NN cord-018225-dozmy3lb 158 10 of of IN cord-018225-dozmy3lb 158 11 all all PDT cord-018225-dozmy3lb 158 12 the the DT cord-018225-dozmy3lb 158 13 groups group NNS cord-018225-dozmy3lb 158 14 . . . cord-018225-dozmy3lb 159 1 Conventional conventional JJ cord-018225-dozmy3lb 159 2 ' ' POS cord-018225-dozmy3lb 159 3 liver liver NN cord-018225-dozmy3lb 159 4 function function NN cord-018225-dozmy3lb 159 5 tests test NNS cord-018225-dozmy3lb 159 6 ' ' POS cord-018225-dozmy3lb 159 7 measure measure NN cord-018225-dozmy3lb 159 8 liver liver NN cord-018225-dozmy3lb 159 9 damage damage NN cord-018225-dozmy3lb 159 10 rather rather RB cord-018225-dozmy3lb 159 11 than than IN cord-018225-dozmy3lb 159 12 liver liver NN cord-018225-dozmy3lb 159 13 function function NN cord-018225-dozmy3lb 159 14 . . . cord-018225-dozmy3lb 160 1 The the DT cord-018225-dozmy3lb 160 2 MEGX MEGX NNP cord-018225-dozmy3lb 160 3 test test NN cord-018225-dozmy3lb 160 4 assesses assess VBZ cord-018225-dozmy3lb 160 5 the the DT cord-018225-dozmy3lb 160 6 liver liver NN cord-018225-dozmy3lb 160 7 's 's POS cord-018225-dozmy3lb 160 8 capacity capacity NN cord-018225-dozmy3lb 160 9 to to TO cord-018225-dozmy3lb 160 10 metabolize metabolize VB cord-018225-dozmy3lb 160 11 drugs drug NNS cord-018225-dozmy3lb 160 12 ( ( -LRB- cord-018225-dozmy3lb 160 13 in in IN cord-018225-dozmy3lb 160 14 this this DT cord-018225-dozmy3lb 160 15 case case NN cord-018225-dozmy3lb 160 16 lignocaine lignocaine NN cord-018225-dozmy3lb 160 17 ) ) -RRB- cord-018225-dozmy3lb 160 18 , , , cord-018225-dozmy3lb 160 19 and and CC cord-018225-dozmy3lb 160 20 thus thus RB cord-018225-dozmy3lb 160 21 is be VBZ cord-018225-dozmy3lb 160 22 a a DT cord-018225-dozmy3lb 160 23 true true JJ cord-018225-dozmy3lb 160 24 ' ' `` cord-018225-dozmy3lb 160 25 liver liver NN cord-018225-dozmy3lb 160 26 function function NN cord-018225-dozmy3lb 160 27 test test NN cord-018225-dozmy3lb 160 28 ' ' '' cord-018225-dozmy3lb 160 29 . . . cord-018225-dozmy3lb 161 1 The the DT cord-018225-dozmy3lb 161 2 data datum NNS cord-018225-dozmy3lb 161 3 presented present VBN cord-018225-dozmy3lb 161 4 in in IN cord-018225-dozmy3lb 161 5 this this DT cord-018225-dozmy3lb 161 6 study study NN cord-018225-dozmy3lb 161 7 suggest suggest VBP cord-018225-dozmy3lb 161 8 that that IN cord-018225-dozmy3lb 161 9 the the DT cord-018225-dozmy3lb 161 10 15-minute 15-minute JJ cord-018225-dozmy3lb 161 11 MEGX MEGX NNP cord-018225-dozmy3lb 161 12 concentration concentration NN cord-018225-dozmy3lb 161 13 varies vary VBZ cord-018225-dozmy3lb 161 14 with with IN cord-018225-dozmy3lb 161 15 the the DT cord-018225-dozmy3lb 161 16 adequacy adequacy NN cord-018225-dozmy3lb 161 17 of of IN cord-018225-dozmy3lb 161 18 liver liver NN cord-018225-dozmy3lb 161 19 function function NN cord-018225-dozmy3lb 161 20 . . . cord-018225-dozmy3lb 162 1 This this DT cord-018225-dozmy3lb 162 2 paper paper NN cord-018225-dozmy3lb 162 3 is be VBZ cord-018225-dozmy3lb 162 4 the the DT cord-018225-dozmy3lb 162 5 first first JJ cord-018225-dozmy3lb 162 6 to to TO cord-018225-dozmy3lb 162 7 describe describe VB cord-018225-dozmy3lb 162 8 and and CC cord-018225-dozmy3lb 162 9 assess assess VB cord-018225-dozmy3lb 162 10 the the DT cord-018225-dozmy3lb 162 11 formation formation NN cord-018225-dozmy3lb 162 12 of of IN cord-018225-dozmy3lb 162 13 MEGX MEGX NNP cord-018225-dozmy3lb 162 14 after after IN cord-018225-dozmy3lb 162 15 a a DT cord-018225-dozmy3lb 162 16 standard standard JJ cord-018225-dozmy3lb 162 17 dose dose NN cord-018225-dozmy3lb 162 18 of of IN cord-018225-dozmy3lb 162 19 lignocaine lignocaine NN cord-018225-dozmy3lb 162 20 as as IN cord-018225-dozmy3lb 162 21 a a DT cord-018225-dozmy3lb 162 22 dynamic dynamic JJ cord-018225-dozmy3lb 162 23 liver liver NN cord-018225-dozmy3lb 162 24 function function NN cord-018225-dozmy3lb 162 25 test test NN cord-018225-dozmy3lb 162 26 . . . cord-018225-dozmy3lb 163 1 Novel novel JJ cord-018225-dozmy3lb 163 2 approach approach NN cord-018225-dozmy3lb 163 3 . . . cord-018225-dozmy3lb 164 1 The the DT cord-018225-dozmy3lb 164 2 test test NN cord-018225-dozmy3lb 164 3 is be VBZ cord-018225-dozmy3lb 164 4 not not RB cord-018225-dozmy3lb 164 5 well well RB cord-018225-dozmy3lb 164 6 validated validate VBN cord-018225-dozmy3lb 164 7 in in IN cord-018225-dozmy3lb 164 8 this this DT cord-018225-dozmy3lb 164 9 report report NN cord-018225-dozmy3lb 164 10 . . . cord-018225-dozmy3lb 165 1 Because because IN cord-018225-dozmy3lb 165 2 of of IN cord-018225-dozmy3lb 165 3 its -PRON- PRP$ cord-018225-dozmy3lb 165 4 ease ease NN cord-018225-dozmy3lb 165 5 of of IN cord-018225-dozmy3lb 165 6 use use NN cord-018225-dozmy3lb 165 7 and and CC cord-018225-dozmy3lb 165 8 rapid rapid JJ cord-018225-dozmy3lb 165 9 turnaround turnaround NN cord-018225-dozmy3lb 165 10 , , , cord-018225-dozmy3lb 165 11 the the DT cord-018225-dozmy3lb 165 12 MEGX MEGX NNP cord-018225-dozmy3lb 165 13 test test NN cord-018225-dozmy3lb 165 14 has have VBZ cord-018225-dozmy3lb 165 15 found find VBN cord-018225-dozmy3lb 165 16 widespread widespread JJ cord-018225-dozmy3lb 165 17 application application NN cord-018225-dozmy3lb 165 18 for for IN cord-018225-dozmy3lb 165 19 the the DT cord-018225-dozmy3lb 165 20 real real JJ cord-018225-dozmy3lb 165 21 - - HYPH cord-018225-dozmy3lb 165 22 time time NN cord-018225-dozmy3lb 165 23 assessment assessment NN cord-018225-dozmy3lb 165 24 of of IN cord-018225-dozmy3lb 165 25 hepatic hepatic JJ cord-018225-dozmy3lb 165 26 function function NN cord-018225-dozmy3lb 165 27 . . . cord-018225-dozmy3lb 166 1 In in IN cord-018225-dozmy3lb 166 2 liver liver NN cord-018225-dozmy3lb 166 3 transplantation transplantation NN cord-018225-dozmy3lb 166 4 , , , cord-018225-dozmy3lb 166 5 the the DT cord-018225-dozmy3lb 166 6 MEGX MEGX NNP cord-018225-dozmy3lb 166 7 test test NN cord-018225-dozmy3lb 166 8 has have VBZ cord-018225-dozmy3lb 166 9 found find VBN cord-018225-dozmy3lb 166 10 a a DT cord-018225-dozmy3lb 166 11 place place NN cord-018225-dozmy3lb 166 12 in in IN cord-018225-dozmy3lb 166 13 selection selection NN cord-018225-dozmy3lb 166 14 of of IN cord-018225-dozmy3lb 166 15 transplant transplant NN cord-018225-dozmy3lb 166 16 candidates candidate NNS cord-018225-dozmy3lb 166 17 , , , cord-018225-dozmy3lb 166 18 and and CC cord-018225-dozmy3lb 166 19 in in IN cord-018225-dozmy3lb 166 20 monitoring monitoring NN cord-018225-dozmy3lb 166 21 of of IN cord-018225-dozmy3lb 166 22 liver liver NN cord-018225-dozmy3lb 166 23 recipients recipient NNS cord-018225-dozmy3lb 166 24 early early RB cord-018225-dozmy3lb 166 25 after after IN cord-018225-dozmy3lb 166 26 transplantation transplantation NN cord-018225-dozmy3lb 166 27 . . . cord-018225-dozmy3lb 167 1 In in IN cord-018225-dozmy3lb 167 2 intensive intensive JJ cord-018225-dozmy3lb 167 3 care care NN cord-018225-dozmy3lb 167 4 patients patient NNS cord-018225-dozmy3lb 167 5 , , , cord-018225-dozmy3lb 167 6 a a DT cord-018225-dozmy3lb 167 7 rapid rapid JJ cord-018225-dozmy3lb 167 8 decrease decrease NN cord-018225-dozmy3lb 167 9 in in IN cord-018225-dozmy3lb 167 10 MEGX MEGX NNP cord-018225-dozmy3lb 167 11 test test NN cord-018225-dozmy3lb 167 12 values value NNS cord-018225-dozmy3lb 167 13 is be VBZ cord-018225-dozmy3lb 167 14 associated associate VBN cord-018225-dozmy3lb 167 15 with with IN cord-018225-dozmy3lb 167 16 increased increase VBN cord-018225-dozmy3lb 167 17 risk risk NN cord-018225-dozmy3lb 167 18 of of IN cord-018225-dozmy3lb 167 19 developing develop VBG cord-018225-dozmy3lb 167 20 multiple multiple JJ cord-018225-dozmy3lb 167 21 organ organ NN cord-018225-dozmy3lb 167 22 failure failure NN cord-018225-dozmy3lb 167 23 , , , cord-018225-dozmy3lb 167 24 and and CC cord-018225-dozmy3lb 167 25 a a DT cord-018225-dozmy3lb 167 26 poor poor JJ cord-018225-dozmy3lb 167 27 outcome outcome NN cord-018225-dozmy3lb 167 28 , , , cord-018225-dozmy3lb 167 29 and and CC cord-018225-dozmy3lb 167 30 consequently consequently RB cord-018225-dozmy3lb 167 31 may may MD cord-018225-dozmy3lb 167 32 have have VB cord-018225-dozmy3lb 167 33 a a DT cord-018225-dozmy3lb 167 34 role role NN cord-018225-dozmy3lb 167 35 in in IN cord-018225-dozmy3lb 167 36 investigation investigation NN cord-018225-dozmy3lb 167 37 of of IN cord-018225-dozmy3lb 167 38 the the DT cord-018225-dozmy3lb 167 39 role role NN cord-018225-dozmy3lb 167 40 of of IN cord-018225-dozmy3lb 167 41 the the DT cord-018225-dozmy3lb 167 42 liver liver NN cord-018225-dozmy3lb 167 43 in in IN cord-018225-dozmy3lb 167 44 the the DT cord-018225-dozmy3lb 167 45 multiple multiple JJ cord-018225-dozmy3lb 167 46 organ organ NN cord-018225-dozmy3lb 167 47 failure failure NN cord-018225-dozmy3lb 167 48 syndrome syndrome NN cord-018225-dozmy3lb 167 49 . . . cord-018225-dozmy3lb 167 50 _SP cord-018225-dozmy3lb 168 1 The the DT cord-018225-dozmy3lb 168 2 successful successful JJ cord-018225-dozmy3lb 168 3 use use NN cord-018225-dozmy3lb 168 4 of of IN cord-018225-dozmy3lb 168 5 orthotopic orthotopic JJ cord-018225-dozmy3lb 168 6 liver liver NN cord-018225-dozmy3lb 168 7 transplantation transplantation NN cord-018225-dozmy3lb 168 8 in in IN cord-018225-dozmy3lb 168 9 fulminant fulminant JJ cord-018225-dozmy3lb 168 10 hepatic hepatic JJ cord-018225-dozmy3lb 168 11 failure failure NN cord-018225-dozmy3lb 168 12 has have VBZ cord-018225-dozmy3lb 168 13 created create VBN cord-018225-dozmy3lb 168 14 a a DT cord-018225-dozmy3lb 168 15 need need NN cord-018225-dozmy3lb 168 16 for for IN cord-018225-dozmy3lb 168 17 early early JJ cord-018225-dozmy3lb 168 18 prognostic prognostic JJ cord-018225-dozmy3lb 168 19 indicators indicator NNS cord-018225-dozmy3lb 168 20 to to TO cord-018225-dozmy3lb 168 21 select select VB cord-018225-dozmy3lb 168 22 the the DT cord-018225-dozmy3lb 168 23 patients patient NNS cord-018225-dozmy3lb 168 24 most most RBS cord-018225-dozmy3lb 168 25 likely likely JJ cord-018225-dozmy3lb 168 26 to to TO cord-018225-dozmy3lb 168 27 benefit benefit VB cord-018225-dozmy3lb 168 28 at at IN cord-018225-dozmy3lb 168 29 a a DT cord-018225-dozmy3lb 168 30 time time NN cord-018225-dozmy3lb 168 31 when when WRB cord-018225-dozmy3lb 168 32 liver liver NN cord-018225-dozmy3lb 168 33 transplantation transplantation NN cord-018225-dozmy3lb 168 34 is be VBZ cord-018225-dozmy3lb 168 35 still still RB cord-018225-dozmy3lb 168 36 feasible feasible JJ cord-018225-dozmy3lb 168 37 . . . cord-018225-dozmy3lb 169 1 Univariate univariate JJ cord-018225-dozmy3lb 169 2 and and CC cord-018225-dozmy3lb 169 3 multivariate multivariate JJ cord-018225-dozmy3lb 169 4 analysis analysis NN cord-018225-dozmy3lb 169 5 was be VBD cord-018225-dozmy3lb 169 6 performed perform VBN cord-018225-dozmy3lb 169 7 on on IN cord-018225-dozmy3lb 169 8 588 588 CD cord-018225-dozmy3lb 169 9 patients patient NNS cord-018225-dozmy3lb 169 10 with with IN cord-018225-dozmy3lb 169 11 acute acute JJ cord-018225-dozmy3lb 169 12 liver liver NN cord-018225-dozmy3lb 169 13 failure failure NN cord-018225-dozmy3lb 169 14 managed manage VBD cord-018225-dozmy3lb 169 15 medically medically RB cord-018225-dozmy3lb 169 16 during during IN cord-018225-dozmy3lb 169 17 1973 1973 CD cord-018225-dozmy3lb 169 18 - - SYM cord-018225-dozmy3lb 169 19 1985 1985 CD cord-018225-dozmy3lb 169 20 , , , cord-018225-dozmy3lb 169 21 to to TO cord-018225-dozmy3lb 169 22 identify identify VB cord-018225-dozmy3lb 169 23 the the DT cord-018225-dozmy3lb 169 24 factors factor NNS cord-018225-dozmy3lb 169 25 most most RBS cord-018225-dozmy3lb 169 26 likely likely JJ cord-018225-dozmy3lb 169 27 to to TO cord-018225-dozmy3lb 169 28 indicate indicate VB cord-018225-dozmy3lb 169 29 a a DT cord-018225-dozmy3lb 169 30 poor poor JJ cord-018225-dozmy3lb 169 31 prognosis prognosis NN cord-018225-dozmy3lb 169 32 . . . cord-018225-dozmy3lb 170 1 In in IN cord-018225-dozmy3lb 170 2 acetaminophen acetaminophen NN cord-018225-dozmy3lb 170 3 - - HYPH cord-018225-dozmy3lb 170 4 induced induce VBN cord-018225-dozmy3lb 170 5 fulminant fulminant JJ cord-018225-dozmy3lb 170 6 hepatic hepatic JJ cord-018225-dozmy3lb 170 7 failure failure NN cord-018225-dozmy3lb 170 8 , , , cord-018225-dozmy3lb 170 9 survival survival NN cord-018225-dozmy3lb 170 10 correlated correlate VBN cord-018225-dozmy3lb 170 11 with with IN cord-018225-dozmy3lb 170 12 arterial arterial JJ cord-018225-dozmy3lb 170 13 blood blood NN cord-018225-dozmy3lb 170 14 pH ph NN cord-018225-dozmy3lb 170 15 , , , cord-018225-dozmy3lb 170 16 peak peak JJ cord-018225-dozmy3lb 170 17 prothrombin prothrombin NN cord-018225-dozmy3lb 170 18 time time NN cord-018225-dozmy3lb 170 19 , , , cord-018225-dozmy3lb 170 20 and and CC cord-018225-dozmy3lb 170 21 serum serum NN cord-018225-dozmy3lb 170 22 creatinine creatinine NN cord-018225-dozmy3lb 170 23 -a -a . cord-018225-dozmy3lb 171 1 pH pH NNP cord-018225-dozmy3lb 171 2 < < NNP cord-018225-dozmy3lb 171 3 7.30 7.30 CD cord-018225-dozmy3lb 171 4 , , , cord-018225-dozmy3lb 171 5 prothrombin prothrombin JJ cord-018225-dozmy3lb 171 6 time time NN cord-018225-dozmy3lb 172 1 > > XX cord-018225-dozmy3lb 172 2 100 100 CD cord-018225-dozmy3lb 172 3 seconds second NNS cord-018225-dozmy3lb 172 4 , , , cord-018225-dozmy3lb 172 5 and and CC cord-018225-dozmy3lb 172 6 creatinine creatinine NN cord-018225-dozmy3lb 172 7 > > XX cord-018225-dozmy3lb 173 1 300 300 CD cord-018225-dozmy3lb 173 2 µmol µmol NNP cord-018225-dozmy3lb 173 3 / / SYM cord-018225-dozmy3lb 173 4 L L NNP cord-018225-dozmy3lb 173 5 indicated indicate VBD cord-018225-dozmy3lb 173 6 a a DT cord-018225-dozmy3lb 173 7 poor poor JJ cord-018225-dozmy3lb 173 8 prognosis prognosis NN cord-018225-dozmy3lb 173 9 . . . cord-018225-dozmy3lb 174 1 In in IN cord-018225-dozmy3lb 174 2 patients patient NNS cord-018225-dozmy3lb 174 3 with with IN cord-018225-dozmy3lb 174 4 viral viral JJ cord-018225-dozmy3lb 174 5 hepatitis hepatitis NN cord-018225-dozmy3lb 174 6 and and CC cord-018225-dozmy3lb 174 7 drug drug NN cord-018225-dozmy3lb 174 8 reactions reaction NNS cord-018225-dozmy3lb 174 9 , , , cord-018225-dozmy3lb 174 10 three three CD cord-018225-dozmy3lb 174 11 static static JJ cord-018225-dozmy3lb 174 12 variables variable NNS cord-018225-dozmy3lb 174 13 [ [ -LRB- cord-018225-dozmy3lb 174 14 etiology etiology NN cord-018225-dozmy3lb 174 15 ( ( -LRB- cord-018225-dozmy3lb 174 16 non non FW cord-018225-dozmy3lb 174 17 A A NNP cord-018225-dozmy3lb 174 18 , , , cord-018225-dozmy3lb 174 19 non non NNP cord-018225-dozmy3lb 174 20 B B NNP cord-018225-dozmy3lb 174 21 hepatitis hepatitis NN cord-018225-dozmy3lb 174 22 or or CC cord-018225-dozmy3lb 174 23 drug drug NN cord-018225-dozmy3lb 174 24 reactions reaction NNS cord-018225-dozmy3lb 174 25 ) ) -RRB- cord-018225-dozmy3lb 174 26 , , , cord-018225-dozmy3lb 174 27 age age NN cord-018225-dozmy3lb 174 28 < < XX cord-018225-dozmy3lb 174 29 11 11 CD cord-018225-dozmy3lb 174 30 and and CC cord-018225-dozmy3lb 174 31 > > XX cord-018225-dozmy3lb 174 32 40 40 CD cord-018225-dozmy3lb 174 33 year year NN cord-018225-dozmy3lb 174 34 , , , cord-018225-dozmy3lb 174 35 duration duration NN cord-018225-dozmy3lb 174 36 of of IN cord-018225-dozmy3lb 174 37 jaundice jaundice NN cord-018225-dozmy3lb 174 38 before before IN cord-018225-dozmy3lb 174 39 the the DT cord-018225-dozmy3lb 174 40 onset onset NN cord-018225-dozmy3lb 174 41 of of IN cord-018225-dozmy3lb 174 42 encephalopathy encephalopathy NN cord-018225-dozmy3lb 174 43 > > XX cord-018225-dozmy3lb 174 44 7 7 CD cord-018225-dozmy3lb 174 45 days day NNS cord-018225-dozmy3lb 174 46 ] ] -RRB- cord-018225-dozmy3lb 174 47 , , , cord-018225-dozmy3lb 174 48 and and CC cord-018225-dozmy3lb 174 49 two two CD cord-018225-dozmy3lb 174 50 dynamic dynamic JJ cord-018225-dozmy3lb 174 51 variables variable NNS cord-018225-dozmy3lb 174 52 ( ( -LRB- cord-018225-dozmy3lb 174 53 serum serum NN cord-018225-dozmy3lb 174 54 bilirubin bilirubin NN cord-018225-dozmy3lb 174 55 > > XX cord-018225-dozmy3lb 174 56 300 300 CD cord-018225-dozmy3lb 174 57 µmol µmol NNP cord-018225-dozmy3lb 174 58 / / SYM cord-018225-dozmy3lb 174 59 L l NN cord-018225-dozmy3lb 174 60 , , , cord-018225-dozmy3lb 174 61 and and CC cord-018225-dozmy3lb 174 62 prothrombin prothrombin NN cord-018225-dozmy3lb 174 63 time time NN cord-018225-dozmy3lb 174 64 > > XX cord-018225-dozmy3lb 174 65 50 50 CD cord-018225-dozmy3lb 174 66 seconds second NNS cord-018225-dozmy3lb 174 67 ) ) -RRB- cord-018225-dozmy3lb 174 68 indicated indicate VBD cord-018225-dozmy3lb 174 69 a a DT cord-018225-dozmy3lb 174 70 poor poor JJ cord-018225-dozmy3lb 174 71 prognosis prognosis NN cord-018225-dozmy3lb 174 72 . . . cord-018225-dozmy3lb 175 1 The the DT cord-018225-dozmy3lb 175 2 value value NN cord-018225-dozmy3lb 175 3 of of IN cord-018225-dozmy3lb 175 4 these these DT cord-018225-dozmy3lb 175 5 indicators indicator NNS cord-018225-dozmy3lb 175 6 in in IN cord-018225-dozmy3lb 175 7 determining determine VBG cord-018225-dozmy3lb 175 8 outcome outcome NN cord-018225-dozmy3lb 175 9 was be VBD cord-018225-dozmy3lb 175 10 tested test VBN cord-018225-dozmy3lb 175 11 retrospectively retrospectively RB cord-018225-dozmy3lb 175 12 in in IN cord-018225-dozmy3lb 175 13 a a DT cord-018225-dozmy3lb 175 14 further further JJ cord-018225-dozmy3lb 175 15 175 175 CD cord-018225-dozmy3lb 175 16 patients patient NNS cord-018225-dozmy3lb 175 17 admitted admit VBN cord-018225-dozmy3lb 175 18 during during IN cord-018225-dozmy3lb 175 19 1986 1986 CD cord-018225-dozmy3lb 175 20 - - SYM cord-018225-dozmy3lb 175 21 1987 1987 CD cord-018225-dozmy3lb 175 22 , , , cord-018225-dozmy3lb 175 23 leading lead VBG cord-018225-dozmy3lb 175 24 to to IN cord-018225-dozmy3lb 175 25 the the DT cord-018225-dozmy3lb 175 26 construction construction NN cord-018225-dozmy3lb 175 27 of of IN cord-018225-dozmy3lb 175 28 models model NNS cord-018225-dozmy3lb 175 29 for for IN cord-018225-dozmy3lb 175 30 the the DT cord-018225-dozmy3lb 175 31 selection selection NN cord-018225-dozmy3lb 175 32 of of IN cord-018225-dozmy3lb 175 33 patients patient NNS cord-018225-dozmy3lb 175 34 for for IN cord-018225-dozmy3lb 175 35 liver liver NN cord-018225-dozmy3lb 175 36 transplantation transplantation NN cord-018225-dozmy3lb 175 37 . . . cord-018225-dozmy3lb 176 1 The the DT cord-018225-dozmy3lb 176 2 records record NNS cord-018225-dozmy3lb 176 3 of of IN cord-018225-dozmy3lb 176 4 588 588 CD cord-018225-dozmy3lb 176 5 patients patient NNS cord-018225-dozmy3lb 176 6 with with IN cord-018225-dozmy3lb 176 7 fulminant fulminant JJ cord-018225-dozmy3lb 176 8 hepatic hepatic JJ cord-018225-dozmy3lb 176 9 failure failure NN cord-018225-dozmy3lb 176 10 ( ( -LRB- cord-018225-dozmy3lb 176 11 FHF FHF NNP cord-018225-dozmy3lb 176 12 ) ) -RRB- cord-018225-dozmy3lb 176 13 and and CC cord-018225-dozmy3lb 176 14 grade grade NN cord-018225-dozmy3lb 176 15 III III NNP cord-018225-dozmy3lb 176 16 or or CC cord-018225-dozmy3lb 176 17 IV IV NNP cord-018225-dozmy3lb 176 18 encephalopathy encephalopathy NN cord-018225-dozmy3lb 176 19 admitted admit VBD cord-018225-dozmy3lb 176 20 to to IN cord-018225-dozmy3lb 176 21 King King NNP cord-018225-dozmy3lb 176 22 's 's POS cord-018225-dozmy3lb 176 23 College College NNP cord-018225-dozmy3lb 176 24 Hospital Hospital NNP cord-018225-dozmy3lb 176 25 , , , cord-018225-dozmy3lb 176 26 London London NNP cord-018225-dozmy3lb 176 27 , , , cord-018225-dozmy3lb 176 28 between between IN cord-018225-dozmy3lb 176 29 1973 1973 CD cord-018225-dozmy3lb 176 30 and and CC cord-018225-dozmy3lb 176 31 1985 1985 CD cord-018225-dozmy3lb 176 32 , , , cord-018225-dozmy3lb 176 33 were be VBD cord-018225-dozmy3lb 176 34 scrutinized scrutinize VBN cord-018225-dozmy3lb 176 35 to to TO cord-018225-dozmy3lb 176 36 identify identify VB cord-018225-dozmy3lb 176 37 simple simple JJ cord-018225-dozmy3lb 176 38 parameters parameter NNS cord-018225-dozmy3lb 176 39 that that WDT cord-018225-dozmy3lb 176 40 might may MD cord-018225-dozmy3lb 176 41 prove prove VB cord-018225-dozmy3lb 176 42 to to TO cord-018225-dozmy3lb 176 43 be be VB cord-018225-dozmy3lb 176 44 prognostic prognostic JJ cord-018225-dozmy3lb 176 45 indicators indicator NNS cord-018225-dozmy3lb 176 46 . . . cord-018225-dozmy3lb 177 1 These these DT cord-018225-dozmy3lb 177 2 parameters parameter NNS cord-018225-dozmy3lb 177 3 were be VBD cord-018225-dozmy3lb 177 4 examined examine VBN cord-018225-dozmy3lb 177 5 by by IN cord-018225-dozmy3lb 177 6 univariate univariate JJ cord-018225-dozmy3lb 177 7 and and CC cord-018225-dozmy3lb 177 8 multivariate multivariate JJ cord-018225-dozmy3lb 177 9 analysis analysis NN cord-018225-dozmy3lb 177 10 to to TO cord-018225-dozmy3lb 177 11 determine determine VB cord-018225-dozmy3lb 177 12 the the DT cord-018225-dozmy3lb 177 13 factors factor NNS cord-018225-dozmy3lb 177 14 most most RBS cord-018225-dozmy3lb 177 15 likely likely JJ cord-018225-dozmy3lb 177 16 to to TO cord-018225-dozmy3lb 177 17 be be VB cord-018225-dozmy3lb 177 18 associated associate VBN cord-018225-dozmy3lb 177 19 with with IN cord-018225-dozmy3lb 177 20 poor poor JJ cord-018225-dozmy3lb 177 21 prognosis prognosis NN cord-018225-dozmy3lb 177 22 . . . cord-018225-dozmy3lb 178 1 The the DT cord-018225-dozmy3lb 178 2 analysis analysis NN cord-018225-dozmy3lb 178 3 was be VBD cord-018225-dozmy3lb 178 4 performed perform VBN cord-018225-dozmy3lb 178 5 in in IN cord-018225-dozmy3lb 178 6 two two CD cord-018225-dozmy3lb 178 7 groups group NNS cord-018225-dozmy3lb 178 8 , , , cord-018225-dozmy3lb 178 9 paracetamol paracetamol NN cord-018225-dozmy3lb 178 10 - - HYPH cord-018225-dozmy3lb 178 11 induced induce VBN cord-018225-dozmy3lb 178 12 and and CC cord-018225-dozmy3lb 178 13 non non JJ cord-018225-dozmy3lb 178 14 - - JJ cord-018225-dozmy3lb 178 15 paracetamol paracetamol JJ cord-018225-dozmy3lb 178 16 - - HYPH cord-018225-dozmy3lb 178 17 induced induce VBN cord-018225-dozmy3lb 178 18 , , , cord-018225-dozmy3lb 178 19 because because IN cord-018225-dozmy3lb 178 20 of of IN cord-018225-dozmy3lb 178 21 the the DT cord-018225-dozmy3lb 178 22 higher high JJR cord-018225-dozmy3lb 178 23 incidence incidence NN cord-018225-dozmy3lb 178 24 of of IN cord-018225-dozmy3lb 178 25 renal renal JJ cord-018225-dozmy3lb 178 26 failure failure NN cord-018225-dozmy3lb 178 27 and and CC cord-018225-dozmy3lb 178 28 metabolic metabolic JJ cord-018225-dozmy3lb 178 29 acidosis acidosis NN cord-018225-dozmy3lb 178 30 in in IN cord-018225-dozmy3lb 178 31 the the DT cord-018225-dozmy3lb 178 32 former former JJ cord-018225-dozmy3lb 178 33 group group NN cord-018225-dozmy3lb 178 34 . . . cord-018225-dozmy3lb 179 1 The the DT cord-018225-dozmy3lb 179 2 prognostic prognostic JJ cord-018225-dozmy3lb 179 3 indicators indicator NNS cord-018225-dozmy3lb 179 4 so so RB cord-018225-dozmy3lb 179 5 determined determined JJ cord-018225-dozmy3lb 179 6 were be VBD cord-018225-dozmy3lb 179 7 then then RB cord-018225-dozmy3lb 179 8 examined examine VBN cord-018225-dozmy3lb 179 9 retrospectively retrospectively RB cord-018225-dozmy3lb 179 10 , , , cord-018225-dozmy3lb 179 11 in in IN cord-018225-dozmy3lb 179 12 a a DT cord-018225-dozmy3lb 179 13 second second JJ cord-018225-dozmy3lb 179 14 group group NN cord-018225-dozmy3lb 179 15 of of IN cord-018225-dozmy3lb 179 16 175 175 CD cord-018225-dozmy3lb 179 17 patients patient NNS cord-018225-dozmy3lb 179 18 with with IN cord-018225-dozmy3lb 179 19 FHF FHF NNP cord-018225-dozmy3lb 179 20 admitted admit VBD cord-018225-dozmy3lb 179 21 during during IN cord-018225-dozmy3lb 179 22 1986 1986 CD cord-018225-dozmy3lb 179 23 - - SYM cord-018225-dozmy3lb 179 24 1987 1987 CD cord-018225-dozmy3lb 179 25 , , , cord-018225-dozmy3lb 179 26 to to TO cord-018225-dozmy3lb 179 27 determine determine VB cord-018225-dozmy3lb 179 28 their -PRON- PRP$ cord-018225-dozmy3lb 179 29 sensitivity sensitivity NN cord-018225-dozmy3lb 179 30 and and CC cord-018225-dozmy3lb 179 31 specificity specificity NN cord-018225-dozmy3lb 179 32 in in IN cord-018225-dozmy3lb 179 33 prediction prediction NN cord-018225-dozmy3lb 179 34 of of IN cord-018225-dozmy3lb 179 35 a a DT cord-018225-dozmy3lb 179 36 fatal fatal JJ cord-018225-dozmy3lb 179 37 outcome outcome NN cord-018225-dozmy3lb 179 38 . . . cord-018225-dozmy3lb 180 1 Models model NNS cord-018225-dozmy3lb 180 2 were be VBD cord-018225-dozmy3lb 180 3 then then RB cord-018225-dozmy3lb 180 4 constructed construct VBN cord-018225-dozmy3lb 180 5 for for IN cord-018225-dozmy3lb 180 6 selection selection NN cord-018225-dozmy3lb 180 7 of of IN cord-018225-dozmy3lb 180 8 patients patient NNS cord-018225-dozmy3lb 180 9 for for IN cord-018225-dozmy3lb 180 10 liver liver NN cord-018225-dozmy3lb 180 11 transplantation transplantation NN cord-018225-dozmy3lb 180 12 on on IN cord-018225-dozmy3lb 180 13 the the DT cord-018225-dozmy3lb 180 14 basis basis NN cord-018225-dozmy3lb 180 15 of of IN cord-018225-dozmy3lb 180 16 an an DT cord-018225-dozmy3lb 180 17 extremely extremely RB cord-018225-dozmy3lb 180 18 poor poor JJ cord-018225-dozmy3lb 180 19 prognosis prognosis NN cord-018225-dozmy3lb 180 20 with with IN cord-018225-dozmy3lb 180 21 medical medical JJ cord-018225-dozmy3lb 180 22 management management NN cord-018225-dozmy3lb 180 23 . . . cord-018225-dozmy3lb 181 1 The the DT cord-018225-dozmy3lb 181 2 criteria criterion NNS cord-018225-dozmy3lb 181 3 adopted adopt VBN cord-018225-dozmy3lb 181 4 for for IN cord-018225-dozmy3lb 181 5 paracetamol paracetamol NN cord-018225-dozmy3lb 181 6 - - HYPH cord-018225-dozmy3lb 181 7 induced induce VBN cord-018225-dozmy3lb 181 8 FHF FHF NNP cord-018225-dozmy3lb 182 1 were be VBD cord-018225-dozmy3lb 182 2 pH pH NNP cord-018225-dozmy3lb 182 3 < < XX cord-018225-dozmy3lb 182 4 7.30 7.30 CD cord-018225-dozmy3lb 183 1 ( ( -LRB- cord-018225-dozmy3lb 183 2 irrespective irrespective RB cord-018225-dozmy3lb 183 3 of of IN cord-018225-dozmy3lb 183 4 grade grade NN cord-018225-dozmy3lb 183 5 of of IN cord-018225-dozmy3lb 183 6 encephalopathy encephalopathy NN cord-018225-dozmy3lb 183 7 ) ) -RRB- cord-018225-dozmy3lb 183 8 , , , cord-018225-dozmy3lb 183 9 or or CC cord-018225-dozmy3lb 183 10 prothrombin prothrombin NN cord-018225-dozmy3lb 183 11 time time NN cord-018225-dozmy3lb 183 12 > > XX cord-018225-dozmy3lb 183 13 100 100 CD cord-018225-dozmy3lb 183 14 seconds second NNS cord-018225-dozmy3lb 183 15 and and CC cord-018225-dozmy3lb 183 16 serum serum NN cord-018225-dozmy3lb 183 17 creatinine creatinine NN cord-018225-dozmy3lb 184 1 > > XX cord-018225-dozmy3lb 185 1 300 300 CD cord-018225-dozmy3lb 185 2 µmol µmol NNP cord-018225-dozmy3lb 185 3 / / SYM cord-018225-dozmy3lb 185 4 L l NN cord-018225-dozmy3lb 185 5 in in IN cord-018225-dozmy3lb 185 6 patients patient NNS cord-018225-dozmy3lb 185 7 with with IN cord-018225-dozmy3lb 185 8 grade grade NN cord-018225-dozmy3lb 185 9 III III NNP cord-018225-dozmy3lb 185 10 or or CC cord-018225-dozmy3lb 185 11 IV IV NNP cord-018225-dozmy3lb 185 12 encephalopathy encephalopathy NN cord-018225-dozmy3lb 185 13 . . . cord-018225-dozmy3lb 186 1 For for IN cord-018225-dozmy3lb 186 2 FHF FHF NNP cord-018225-dozmy3lb 186 3 unrelated unrelated JJ cord-018225-dozmy3lb 186 4 to to IN cord-018225-dozmy3lb 186 5 paracetamol paracetamol NN cord-018225-dozmy3lb 186 6 , , , cord-018225-dozmy3lb 186 7 the the DT cord-018225-dozmy3lb 186 8 criteria criterion NNS cord-018225-dozmy3lb 186 9 determined determine VBN cord-018225-dozmy3lb 186 10 were be VBD cord-018225-dozmy3lb 186 11 prothrombin prothrombin JJ cord-018225-dozmy3lb 186 12 time time NN cord-018225-dozmy3lb 187 1 > > XX cord-018225-dozmy3lb 187 2 100 100 CD cord-018225-dozmy3lb 187 3 seconds second NNS cord-018225-dozmy3lb 187 4 ( ( -LRB- cord-018225-dozmy3lb 187 5 irrespective irrespective RB cord-018225-dozmy3lb 187 6 of of IN cord-018225-dozmy3lb 187 7 grade grade NN cord-018225-dozmy3lb 187 8 of of IN cord-018225-dozmy3lb 187 9 encephalopathy encephalopathy NN cord-018225-dozmy3lb 187 10 ) ) -RRB- cord-018225-dozmy3lb 187 11 , , , cord-018225-dozmy3lb 187 12 or or CC cord-018225-dozmy3lb 187 13 any any DT cord-018225-dozmy3lb 187 14 three three CD cord-018225-dozmy3lb 187 15 of of IN cord-018225-dozmy3lb 187 16 ( ( -LRB- cord-018225-dozmy3lb 187 17 irrespective irrespective RB cord-018225-dozmy3lb 187 18 of of IN cord-018225-dozmy3lb 187 19 grade grade NN cord-018225-dozmy3lb 187 20 of of IN cord-018225-dozmy3lb 187 21 encephalopathy encephalopathy NN cord-018225-dozmy3lb 187 22 ) ) -RRB- cord-018225-dozmy3lb 187 23 : : : cord-018225-dozmy3lb 187 24 age age NN cord-018225-dozmy3lb 187 25 < < XX cord-018225-dozmy3lb 187 26 10 10 CD cord-018225-dozmy3lb 187 27 or or CC cord-018225-dozmy3lb 187 28 > > XX cord-018225-dozmy3lb 187 29 40 40 CD cord-018225-dozmy3lb 187 30 years year NNS cord-018225-dozmy3lb 187 31 , , , cord-018225-dozmy3lb 187 32 etiology etiology NN cord-018225-dozmy3lb 187 33 ( ( -LRB- cord-018225-dozmy3lb 187 34 non non JJ cord-018225-dozmy3lb 187 35 - - JJ cord-018225-dozmy3lb 187 36 A a JJ cord-018225-dozmy3lb 187 37 , , , cord-018225-dozmy3lb 187 38 non non JJ cord-018225-dozmy3lb 187 39 - - JJ cord-018225-dozmy3lb 187 40 B b JJ cord-018225-dozmy3lb 187 41 hepatitis hepatitis NN cord-018225-dozmy3lb 187 42 or or CC cord-018225-dozmy3lb 187 43 idiosyncratic idiosyncratic JJ cord-018225-dozmy3lb 187 44 drug drug NN cord-018225-dozmy3lb 187 45 reactions reaction NNS cord-018225-dozmy3lb 187 46 ) ) -RRB- cord-018225-dozmy3lb 187 47 , , , cord-018225-dozmy3lb 187 48 duration duration NN cord-018225-dozmy3lb 187 49 of of IN cord-018225-dozmy3lb 187 50 jaundice jaundice NN cord-018225-dozmy3lb 187 51 before before IN cord-018225-dozmy3lb 187 52 onset onset NN cord-018225-dozmy3lb 187 53 of of IN cord-018225-dozmy3lb 187 54 encephalopathy encephalopathy NN cord-018225-dozmy3lb 187 55 > > XX cord-018225-dozmy3lb 187 56 7 7 CD cord-018225-dozmy3lb 187 57 days day NNS cord-018225-dozmy3lb 187 58 , , , cord-018225-dozmy3lb 187 59 prothrombin prothrombin JJ cord-018225-dozmy3lb 187 60 time time NN cord-018225-dozmy3lb 187 61 > > XX cord-018225-dozmy3lb 187 62 50 50 CD cord-018225-dozmy3lb 187 63 seconds second NNS cord-018225-dozmy3lb 187 64 , , , cord-018225-dozmy3lb 187 65 and and CC cord-018225-dozmy3lb 187 66 serum serum NN cord-018225-dozmy3lb 187 67 bilirubin bilirubin NN cord-018225-dozmy3lb 188 1 > > XX cord-018225-dozmy3lb 189 1 300 300 CD cord-018225-dozmy3lb 189 2 µmol µmol NNP cord-018225-dozmy3lb 189 3 / / SYM cord-018225-dozmy3lb 189 4 L. L. NNP cord-018225-dozmy3lb 190 1 This this DT cord-018225-dozmy3lb 190 2 study study NN cord-018225-dozmy3lb 190 3 has have VBZ cord-018225-dozmy3lb 190 4 developed develop VBN cord-018225-dozmy3lb 190 5 criteria criterion NNS cord-018225-dozmy3lb 190 6 that that WDT cord-018225-dozmy3lb 190 7 predict predict VBP cord-018225-dozmy3lb 190 8 death death NN cord-018225-dozmy3lb 190 9 in in IN cord-018225-dozmy3lb 190 10 patients patient NNS cord-018225-dozmy3lb 190 11 with with IN cord-018225-dozmy3lb 190 12 FHF FHF NNP cord-018225-dozmy3lb 190 13 who who WP cord-018225-dozmy3lb 190 14 are be VBP cord-018225-dozmy3lb 190 15 managed manage VBN cord-018225-dozmy3lb 190 16 medically medically RB cord-018225-dozmy3lb 190 17 . . . cord-018225-dozmy3lb 191 1 In in IN cord-018225-dozmy3lb 191 2 the the DT cord-018225-dozmy3lb 191 3 era era NN cord-018225-dozmy3lb 191 4 of of IN cord-018225-dozmy3lb 191 5 liver liver NN cord-018225-dozmy3lb 191 6 transplantation transplantation NN cord-018225-dozmy3lb 191 7 , , , cord-018225-dozmy3lb 191 8 these these DT cord-018225-dozmy3lb 191 9 criteria criterion NNS cord-018225-dozmy3lb 191 10 are be VBP cord-018225-dozmy3lb 191 11 also also RB cord-018225-dozmy3lb 191 12 used use VBN cord-018225-dozmy3lb 191 13 to to TO cord-018225-dozmy3lb 191 14 select select VB cord-018225-dozmy3lb 191 15 patients patient NNS cord-018225-dozmy3lb 191 16 for for IN cord-018225-dozmy3lb 191 17 liver liver NN cord-018225-dozmy3lb 191 18 transplantation transplantation NN cord-018225-dozmy3lb 191 19 . . . cord-018225-dozmy3lb 192 1 All all DT cord-018225-dozmy3lb 192 2 patients patient NNS cord-018225-dozmy3lb 192 3 with with IN cord-018225-dozmy3lb 192 4 FHF FHF NNP cord-018225-dozmy3lb 192 5 should should MD cord-018225-dozmy3lb 192 6 be be VB cord-018225-dozmy3lb 192 7 discussed discuss VBN cord-018225-dozmy3lb 192 8 with with IN cord-018225-dozmy3lb 192 9 a a DT cord-018225-dozmy3lb 192 10 transplant transplant NN cord-018225-dozmy3lb 192 11 unit unit NN cord-018225-dozmy3lb 192 12 . . . cord-018225-dozmy3lb 193 1 Patients patient NNS cord-018225-dozmy3lb 193 2 who who WP cord-018225-dozmy3lb 193 3 meet meet VBP cord-018225-dozmy3lb 193 4 these these DT cord-018225-dozmy3lb 193 5 criteria criterion NNS cord-018225-dozmy3lb 193 6 should should MD cord-018225-dozmy3lb 193 7 be be VB cord-018225-dozmy3lb 193 8 transplanted transplant VBN cord-018225-dozmy3lb 193 9 . . . cord-018225-dozmy3lb 194 1 This this DT cord-018225-dozmy3lb 194 2 paper paper NN cord-018225-dozmy3lb 194 3 has have VBZ cord-018225-dozmy3lb 194 4 changed change VBN cord-018225-dozmy3lb 194 5 practice practice NN cord-018225-dozmy3lb 194 6 . . . cord-018225-dozmy3lb 195 1 It -PRON- PRP cord-018225-dozmy3lb 195 2 allows allow VBZ cord-018225-dozmy3lb 195 3 decisions decision NNS cord-018225-dozmy3lb 195 4 to to TO cord-018225-dozmy3lb 195 5 be be VB cord-018225-dozmy3lb 195 6 made make VBN cord-018225-dozmy3lb 195 7 about about IN cord-018225-dozmy3lb 195 8 transplantation transplantation NN cord-018225-dozmy3lb 195 9 in in IN cord-018225-dozmy3lb 195 10 FHF FHF NNP cord-018225-dozmy3lb 195 11 so so IN cord-018225-dozmy3lb 195 12 that that IN cord-018225-dozmy3lb 195 13 unnecessary unnecessary JJ cord-018225-dozmy3lb 195 14 transplantation transplantation NN cord-018225-dozmy3lb 195 15 can can MD cord-018225-dozmy3lb 195 16 be be VB cord-018225-dozmy3lb 195 17 minimized minimize VBN cord-018225-dozmy3lb 195 18 . . . cord-018225-dozmy3lb 196 1 Because because IN cord-018225-dozmy3lb 196 2 the the DT cord-018225-dozmy3lb 196 3 criteria criterion NNS cord-018225-dozmy3lb 196 4 involve involve VBP cord-018225-dozmy3lb 196 5 simple simple JJ cord-018225-dozmy3lb 196 6 , , , cord-018225-dozmy3lb 196 7 easy easy JJ cord-018225-dozmy3lb 196 8 to to TO cord-018225-dozmy3lb 196 9 apply apply VB cord-018225-dozmy3lb 196 10 parameters parameter NNS cord-018225-dozmy3lb 196 11 that that WDT cord-018225-dozmy3lb 196 12 are be VBP cord-018225-dozmy3lb 196 13 readily readily RB cord-018225-dozmy3lb 196 14 available available JJ cord-018225-dozmy3lb 196 15 , , , cord-018225-dozmy3lb 196 16 the the DT cord-018225-dozmy3lb 196 17 algorithm algorithm NN cord-018225-dozmy3lb 196 18 also also RB cord-018225-dozmy3lb 196 19 permits permit VBZ cord-018225-dozmy3lb 196 20 decisions decision NNS cord-018225-dozmy3lb 196 21 to to TO cord-018225-dozmy3lb 196 22 transplant transplant VB cord-018225-dozmy3lb 196 23 to to TO cord-018225-dozmy3lb 196 24 be be VB cord-018225-dozmy3lb 196 25 taken take VBN cord-018225-dozmy3lb 196 26 early early RB cord-018225-dozmy3lb 196 27 , , , cord-018225-dozmy3lb 196 28 maximizing maximize VBG cord-018225-dozmy3lb 196 29 the the DT cord-018225-dozmy3lb 196 30 period period NN cord-018225-dozmy3lb 196 31 of of IN cord-018225-dozmy3lb 196 32 time time NN cord-018225-dozmy3lb 196 33 available available JJ cord-018225-dozmy3lb 196 34 to to TO cord-018225-dozmy3lb 196 35 find find VB cord-018225-dozmy3lb 196 36 a a DT cord-018225-dozmy3lb 196 37 suitable suitable JJ cord-018225-dozmy3lb 196 38 donor donor NN cord-018225-dozmy3lb 196 39 , , , cord-018225-dozmy3lb 196 40 and and CC cord-018225-dozmy3lb 196 41 allowing allow VBG cord-018225-dozmy3lb 196 42 transplantation transplantation NN cord-018225-dozmy3lb 196 43 to to TO cord-018225-dozmy3lb 196 44 be be VB cord-018225-dozmy3lb 196 45 undertaken undertake VBN cord-018225-dozmy3lb 196 46 before before IN cord-018225-dozmy3lb 196 47 the the DT cord-018225-dozmy3lb 196 48 development development NN cord-018225-dozmy3lb 196 49 of of IN cord-018225-dozmy3lb 196 50 cerebral cerebral JJ cord-018225-dozmy3lb 196 51 edema edema NN cord-018225-dozmy3lb 196 52 . . . cord-018225-dozmy3lb 197 1 This this DT cord-018225-dozmy3lb 197 2 study study NN cord-018225-dozmy3lb 197 3 is be VBZ cord-018225-dozmy3lb 197 4 based base VBN cord-018225-dozmy3lb 197 5 on on IN cord-018225-dozmy3lb 197 6 the the DT cord-018225-dozmy3lb 197 7 largest large JJS cord-018225-dozmy3lb 197 8 number number NN cord-018225-dozmy3lb 197 9 of of IN cord-018225-dozmy3lb 197 10 patients patient NNS cord-018225-dozmy3lb 197 11 in in IN cord-018225-dozmy3lb 197 12 a a DT cord-018225-dozmy3lb 197 13 single single JJ cord-018225-dozmy3lb 197 14 unit unit NN cord-018225-dozmy3lb 197 15 ever ever RB cord-018225-dozmy3lb 197 16 reported report VBN cord-018225-dozmy3lb 197 17 . . . cord-018225-dozmy3lb 198 1 Data datum NNS cord-018225-dozmy3lb 198 2 were be VBD cord-018225-dozmy3lb 198 3 collected collect VBN cord-018225-dozmy3lb 198 4 over over IN cord-018225-dozmy3lb 198 5 a a DT cord-018225-dozmy3lb 198 6 period period NN cord-018225-dozmy3lb 198 7 of of IN cord-018225-dozmy3lb 198 8 13 13 CD cord-018225-dozmy3lb 198 9 years year NNS cord-018225-dozmy3lb 198 10 , , , cord-018225-dozmy3lb 198 11 and and CC cord-018225-dozmy3lb 198 12 it -PRON- PRP cord-018225-dozmy3lb 198 13 is be VBZ cord-018225-dozmy3lb 198 14 possible possible JJ cord-018225-dozmy3lb 198 15 that that IN cord-018225-dozmy3lb 198 16 one one CD cord-018225-dozmy3lb 198 17 or or CC cord-018225-dozmy3lb 198 18 more more JJR cord-018225-dozmy3lb 198 19 aspects aspect NNS cord-018225-dozmy3lb 198 20 of of IN cord-018225-dozmy3lb 198 21 management management NN cord-018225-dozmy3lb 198 22 may may MD cord-018225-dozmy3lb 198 23 have have VB cord-018225-dozmy3lb 198 24 changed change VBN cord-018225-dozmy3lb 198 25 in in IN cord-018225-dozmy3lb 198 26 that that DT cord-018225-dozmy3lb 198 27 time time NN cord-018225-dozmy3lb 198 28 , , , cord-018225-dozmy3lb 198 29 and and CC cord-018225-dozmy3lb 198 30 may may MD cord-018225-dozmy3lb 198 31 independently independently RB cord-018225-dozmy3lb 198 32 affect affect VB cord-018225-dozmy3lb 198 33 outcome outcome NN cord-018225-dozmy3lb 198 34 . . . cord-018225-dozmy3lb 199 1 Various various JJ cord-018225-dozmy3lb 199 2 models model NNS cord-018225-dozmy3lb 199 3 have have VBP cord-018225-dozmy3lb 199 4 been be VBN cord-018225-dozmy3lb 199 5 used use VBN cord-018225-dozmy3lb 199 6 to to TO cord-018225-dozmy3lb 199 7 predict predict VB cord-018225-dozmy3lb 199 8 outcome outcome NN cord-018225-dozmy3lb 199 9 in in IN cord-018225-dozmy3lb 199 10 FHF FHF NNP cord-018225-dozmy3lb 199 11 , , , cord-018225-dozmy3lb 199 12 but but CC cord-018225-dozmy3lb 199 13 the the DT cord-018225-dozmy3lb 199 14 ' ' `` cord-018225-dozmy3lb 199 15 King King NNP cord-018225-dozmy3lb 199 16 's 's POS cord-018225-dozmy3lb 199 17 criteria criterion NNS cord-018225-dozmy3lb 199 18 ' ' '' cord-018225-dozmy3lb 199 19 identified identify VBN cord-018225-dozmy3lb 199 20 in in IN cord-018225-dozmy3lb 199 21 this this DT cord-018225-dozmy3lb 199 22 study study NN cord-018225-dozmy3lb 199 23 are be VBP cord-018225-dozmy3lb 199 24 the the DT cord-018225-dozmy3lb 199 25 most most RBS cord-018225-dozmy3lb 199 26 widely widely RB cord-018225-dozmy3lb 199 27 used use VBN cord-018225-dozmy3lb 199 28 . . . cord-018225-dozmy3lb 200 1 These these DT cord-018225-dozmy3lb 200 2 criteria criterion NNS cord-018225-dozmy3lb 200 3 are be VBP cord-018225-dozmy3lb 200 4 based base VBN cord-018225-dozmy3lb 200 5 on on IN cord-018225-dozmy3lb 200 6 the the DT cord-018225-dozmy3lb 200 7 study study NN cord-018225-dozmy3lb 200 8 of of IN cord-018225-dozmy3lb 200 9 a a DT cord-018225-dozmy3lb 200 10 huge huge JJ cord-018225-dozmy3lb 200 11 number number NN cord-018225-dozmy3lb 200 12 of of IN cord-018225-dozmy3lb 200 13 patients patient NNS cord-018225-dozmy3lb 200 14 treated treat VBN cord-018225-dozmy3lb 200 15 medically medically RB cord-018225-dozmy3lb 200 16 , , , cord-018225-dozmy3lb 200 17 and and CC cord-018225-dozmy3lb 200 18 , , , cord-018225-dozmy3lb 200 19 because because IN cord-018225-dozmy3lb 200 20 so so RB cord-018225-dozmy3lb 200 21 many many JJ cord-018225-dozmy3lb 200 22 patients patient NNS cord-018225-dozmy3lb 200 23 are be VBP cord-018225-dozmy3lb 200 24 now now RB cord-018225-dozmy3lb 200 25 transplanted transplant VBN cord-018225-dozmy3lb 200 26 , , , cord-018225-dozmy3lb 200 27 it -PRON- PRP cord-018225-dozmy3lb 200 28 is be VBZ cord-018225-dozmy3lb 200 29 extremely extremely RB cord-018225-dozmy3lb 200 30 unlikely unlikely JJ cord-018225-dozmy3lb 200 31 that that IN cord-018225-dozmy3lb 200 32 the the DT cord-018225-dozmy3lb 200 33 study study NN cord-018225-dozmy3lb 200 34 could could MD cord-018225-dozmy3lb 200 35 ever ever RB cord-018225-dozmy3lb 200 36 be be VB cord-018225-dozmy3lb 200 37 repeated repeat VBN cord-018225-dozmy3lb 200 38 . . . cord-018225-dozmy3lb 201 1 Consequently consequently RB cord-018225-dozmy3lb 201 2 , , , cord-018225-dozmy3lb 201 3 the the DT cord-018225-dozmy3lb 201 4 criteria criterion NNS cord-018225-dozmy3lb 201 5 identified identify VBN cord-018225-dozmy3lb 201 6 in in IN cord-018225-dozmy3lb 201 7 this this DT cord-018225-dozmy3lb 201 8 paper paper NN cord-018225-dozmy3lb 201 9 are be VBP cord-018225-dozmy3lb 201 10 likely likely JJ cord-018225-dozmy3lb 201 11 to to TO cord-018225-dozmy3lb 201 12 be be VB cord-018225-dozmy3lb 201 13 used use VBN cord-018225-dozmy3lb 201 14 widely widely RB cord-018225-dozmy3lb 201 15 to to TO cord-018225-dozmy3lb 201 16 select select VB cord-018225-dozmy3lb 201 17 transplant transplant NN cord-018225-dozmy3lb 201 18 candidates candidate NNS cord-018225-dozmy3lb 201 19 for for IN cord-018225-dozmy3lb 201 20 the the DT cord-018225-dozmy3lb 201 21 foreseeable foreseeable JJ cord-018225-dozmy3lb 201 22 future future NN cord-018225-dozmy3lb 201 23 . . . cord-018225-dozmy3lb 201 24 _SP cord-018225-dozmy3lb 202 1 Orthotopic Orthotopic NNP cord-018225-dozmy3lb 202 2 liver liver NN cord-018225-dozmy3lb 202 3 transplantation transplantation NN cord-018225-dozmy3lb 202 4 was be VBD cord-018225-dozmy3lb 202 5 done do VBN cord-018225-dozmy3lb 202 6 in in IN cord-018225-dozmy3lb 202 7 17 17 CD cord-018225-dozmy3lb 202 8 patients patient NNS cord-018225-dozmy3lb 202 9 with with IN cord-018225-dozmy3lb 202 10 fulminant fulminant JJ cord-018225-dozmy3lb 202 11 hepatitis hepatitis NN cord-018225-dozmy3lb 202 12 . . . cord-018225-dozmy3lb 203 1 The the DT cord-018225-dozmy3lb 203 2 cause cause NN cord-018225-dozmy3lb 203 3 of of IN cord-018225-dozmy3lb 203 4 the the DT cord-018225-dozmy3lb 203 5 liver liver NN cord-018225-dozmy3lb 203 6 disease disease NN cord-018225-dozmy3lb 203 7 was be VBD cord-018225-dozmy3lb 203 8 infection infection NN cord-018225-dozmy3lb 203 9 with with IN cord-018225-dozmy3lb 203 10 hepatitis hepatitis NN cord-018225-dozmy3lb 203 11 B B NNP cord-018225-dozmy3lb 203 12 virus virus NN cord-018225-dozmy3lb 203 13 , , , cord-018225-dozmy3lb 203 14 or or CC cord-018225-dozmy3lb 203 15 co co NN cord-018225-dozmy3lb 203 16 - - NN cord-018225-dozmy3lb 203 17 infection infection NN cord-018225-dozmy3lb 203 18 with with IN cord-018225-dozmy3lb 203 19 hepatitis hepatitis NN cord-018225-dozmy3lb 203 20 B B NNP cord-018225-dozmy3lb 203 21 virus virus NN cord-018225-dozmy3lb 203 22 and and CC cord-018225-dozmy3lb 203 23 hepatitis hepatitis NN cord-018225-dozmy3lb 203 24 D D NNP cord-018225-dozmy3lb 203 25 virus virus NN cord-018225-dozmy3lb 203 26 , , , cord-018225-dozmy3lb 203 27 or or CC cord-018225-dozmy3lb 203 28 infection infection NN cord-018225-dozmy3lb 203 29 with with IN cord-018225-dozmy3lb 203 30 hepatitis hepatitis NN cord-018225-dozmy3lb 203 31 A a DT cord-018225-dozmy3lb 203 32 virus virus NN cord-018225-dozmy3lb 203 33 in in IN cord-018225-dozmy3lb 203 34 6 6 CD cord-018225-dozmy3lb 203 35 patients patient NNS cord-018225-dozmy3lb 203 36 ; ; : cord-018225-dozmy3lb 203 37 drug drug NN cord-018225-dozmy3lb 203 38 hepatotoxicity hepatotoxicity NN cord-018225-dozmy3lb 203 39 in in IN cord-018225-dozmy3lb 203 40 5 5 CD cord-018225-dozmy3lb 203 41 ; ; , cord-018225-dozmy3lb 203 42 and and CC cord-018225-dozmy3lb 203 43 indeterminate indeterminate JJ cord-018225-dozmy3lb 203 44 in in IN cord-018225-dozmy3lb 203 45 6 6 CD cord-018225-dozmy3lb 203 46 . . . cord-018225-dozmy3lb 204 1 Grafts graft NNS cord-018225-dozmy3lb 204 2 from from IN cord-018225-dozmy3lb 204 3 incompatible incompatible JJ cord-018225-dozmy3lb 204 4 blood blood NN cord-018225-dozmy3lb 204 5 groups group NNS cord-018225-dozmy3lb 204 6 , , , cord-018225-dozmy3lb 204 7 steatotic steatotic JJ cord-018225-dozmy3lb 204 8 grafts graft NNS cord-018225-dozmy3lb 204 9 , , , cord-018225-dozmy3lb 204 10 or or CC cord-018225-dozmy3lb 204 11 reduced reduce VBN cord-018225-dozmy3lb 204 12 - - HYPH cord-018225-dozmy3lb 204 13 size size NN cord-018225-dozmy3lb 204 14 grafts graft NNS cord-018225-dozmy3lb 204 15 were be VBD cord-018225-dozmy3lb 204 16 used use VBN cord-018225-dozmy3lb 204 17 in in IN cord-018225-dozmy3lb 204 18 5 5 CD cord-018225-dozmy3lb 204 19 , , , cord-018225-dozmy3lb 204 20 4 4 CD cord-018225-dozmy3lb 204 21 , , , cord-018225-dozmy3lb 204 22 and and CC cord-018225-dozmy3lb 204 23 4 4 CD cord-018225-dozmy3lb 204 24 patients patient NNS cord-018225-dozmy3lb 204 25 , , , cord-018225-dozmy3lb 204 26 respectively respectively RB cord-018225-dozmy3lb 204 27 . . . cord-018225-dozmy3lb 205 1 Of of IN cord-018225-dozmy3lb 205 2 the the DT cord-018225-dozmy3lb 205 3 17 17 CD cord-018225-dozmy3lb 205 4 patients patient NNS cord-018225-dozmy3lb 205 5 , , , cord-018225-dozmy3lb 205 6 5 5 CD cord-018225-dozmy3lb 205 7 died die VBD cord-018225-dozmy3lb 205 8 : : : cord-018225-dozmy3lb 205 9 2 2 CD cord-018225-dozmy3lb 205 10 of of IN cord-018225-dozmy3lb 205 11 early early JJ cord-018225-dozmy3lb 205 12 liver liver NN cord-018225-dozmy3lb 205 13 failure failure NN cord-018225-dozmy3lb 205 14 due due IN cord-018225-dozmy3lb 205 15 to to IN cord-018225-dozmy3lb 205 16 the the DT cord-018225-dozmy3lb 205 17 poor poor JJ cord-018225-dozmy3lb 205 18 quality quality NN cord-018225-dozmy3lb 205 19 of of IN cord-018225-dozmy3lb 205 20 the the DT cord-018225-dozmy3lb 205 21 graft graft NN cord-018225-dozmy3lb 205 22 , , , cord-018225-dozmy3lb 205 23 1 1 CD cord-018225-dozmy3lb 205 24 presumably presumably RB cord-018225-dozmy3lb 205 25 of of IN cord-018225-dozmy3lb 205 26 accidentally accidentally RB cord-018225-dozmy3lb 205 27 transmitted transmit VBN cord-018225-dozmy3lb 205 28 acute acute JJ cord-018225-dozmy3lb 205 29 infection infection NN cord-018225-dozmy3lb 205 30 with with IN cord-018225-dozmy3lb 205 31 the the DT cord-018225-dozmy3lb 205 32 human human JJ cord-018225-dozmy3lb 205 33 immunodeficiency immunodeficiency NN cord-018225-dozmy3lb 205 34 virus virus NN cord-018225-dozmy3lb 205 35 , , , cord-018225-dozmy3lb 205 36 and and CC cord-018225-dozmy3lb 205 37 2 2 CD cord-018225-dozmy3lb 205 38 of of IN cord-018225-dozmy3lb 205 39 decerebration decerebration NN cord-018225-dozmy3lb 205 40 occurring occur VBG cord-018225-dozmy3lb 205 41 during during IN cord-018225-dozmy3lb 205 42 or or CC cord-018225-dozmy3lb 205 43 immediately immediately RB cord-018225-dozmy3lb 205 44 after after IN cord-018225-dozmy3lb 205 45 surgery surgery NN cord-018225-dozmy3lb 205 46 . . . cord-018225-dozmy3lb 206 1 The the DT cord-018225-dozmy3lb 206 2 12 12 CD cord-018225-dozmy3lb 206 3 other other JJ cord-018225-dozmy3lb 206 4 patients patient NNS cord-018225-dozmy3lb 206 5 were be VBD cord-018225-dozmy3lb 206 6 alive alive JJ cord-018225-dozmy3lb 206 7 2 2 CD cord-018225-dozmy3lb 206 8 to to TO cord-018225-dozmy3lb 206 9 15 15 CD cord-018225-dozmy3lb 206 10 months month NNS cord-018225-dozmy3lb 206 11 after after IN cord-018225-dozmy3lb 206 12 transplantation transplantation NN cord-018225-dozmy3lb 206 13 . . . cord-018225-dozmy3lb 207 1 This this DT cord-018225-dozmy3lb 207 2 paper paper NN cord-018225-dozmy3lb 207 3 reports report VBZ cord-018225-dozmy3lb 207 4 the the DT cord-018225-dozmy3lb 207 5 clinical clinical JJ cord-018225-dozmy3lb 207 6 details detail NNS cord-018225-dozmy3lb 207 7 and and CC cord-018225-dozmy3lb 207 8 outcome outcome NN cord-018225-dozmy3lb 207 9 of of IN cord-018225-dozmy3lb 207 10 17 17 CD cord-018225-dozmy3lb 207 11 patients patient NNS cord-018225-dozmy3lb 207 12 with with IN cord-018225-dozmy3lb 207 13 acute acute JJ cord-018225-dozmy3lb 207 14 liver liver NN cord-018225-dozmy3lb 207 15 failure failure NN cord-018225-dozmy3lb 207 16 who who WP cord-018225-dozmy3lb 207 17 underwent undergo VBD cord-018225-dozmy3lb 207 18 orthotopic orthotopic JJ cord-018225-dozmy3lb 207 19 liver liver NN cord-018225-dozmy3lb 207 20 transplantation transplantation NN cord-018225-dozmy3lb 207 21 in in IN cord-018225-dozmy3lb 207 22 the the DT cord-018225-dozmy3lb 207 23 mid-1980s mid-1980 NNS cord-018225-dozmy3lb 207 24 , , , cord-018225-dozmy3lb 207 25 in in IN cord-018225-dozmy3lb 207 26 the the DT cord-018225-dozmy3lb 207 27 Hopital Hopital NNP cord-018225-dozmy3lb 207 28 Paul Paul NNP cord-018225-dozmy3lb 207 29 - - HYPH cord-018225-dozmy3lb 207 30 Brousse Brousse NNP cord-018225-dozmy3lb 207 31 , , , cord-018225-dozmy3lb 207 32 Villejuif Villejuif NNP cord-018225-dozmy3lb 207 33 , , , cord-018225-dozmy3lb 207 34 and and CC cord-018225-dozmy3lb 207 35 the the DT cord-018225-dozmy3lb 207 36 Hopital Hopital NNP cord-018225-dozmy3lb 207 37 Beaujon Beaujon NNP cord-018225-dozmy3lb 207 38 , , , cord-018225-dozmy3lb 207 39 Clichy Clichy NNP cord-018225-dozmy3lb 207 40 , , , cord-018225-dozmy3lb 207 41 France France NNP cord-018225-dozmy3lb 207 42 . . . cord-018225-dozmy3lb 208 1 Six six CD cord-018225-dozmy3lb 208 2 patients patient NNS cord-018225-dozmy3lb 208 3 had have VBD cord-018225-dozmy3lb 208 4 documented document VBN cord-018225-dozmy3lb 208 5 viral viral JJ cord-018225-dozmy3lb 208 6 hepatitis hepatitis NN cord-018225-dozmy3lb 208 7 , , , cord-018225-dozmy3lb 208 8 five five CD cord-018225-dozmy3lb 208 9 had have VBD cord-018225-dozmy3lb 208 10 drug drug NN cord-018225-dozmy3lb 208 11 hepatotoxicity hepatotoxicity NN cord-018225-dozmy3lb 208 12 , , , cord-018225-dozmy3lb 208 13 and and CC cord-018225-dozmy3lb 208 14 the the DT cord-018225-dozmy3lb 208 15 cause cause NN cord-018225-dozmy3lb 208 16 was be VBD cord-018225-dozmy3lb 208 17 undetermined undetermined JJ cord-018225-dozmy3lb 208 18 in in IN cord-018225-dozmy3lb 208 19 the the DT cord-018225-dozmy3lb 208 20 remaining remain VBG cord-018225-dozmy3lb 208 21 six six CD cord-018225-dozmy3lb 208 22 . . . cord-018225-dozmy3lb 209 1 Despite despite IN cord-018225-dozmy3lb 209 2 compromises compromise NNS cord-018225-dozmy3lb 209 3 necessitated necessitate VBN cord-018225-dozmy3lb 209 4 by by IN cord-018225-dozmy3lb 209 5 emergency emergency NN cord-018225-dozmy3lb 209 6 transplantation transplantation NN cord-018225-dozmy3lb 209 7 ( ( -LRB- cord-018225-dozmy3lb 209 8 ABO ABO NNP cord-018225-dozmy3lb 209 9 and and CC cord-018225-dozmy3lb 209 10 size size NN cord-018225-dozmy3lb 209 11 incompatibility incompatibility NN cord-018225-dozmy3lb 209 12 , , , cord-018225-dozmy3lb 209 13 and and CC cord-018225-dozmy3lb 209 14 steatotic steatotic JJ cord-018225-dozmy3lb 209 15 grafts graft NNS cord-018225-dozmy3lb 209 16 ) ) -RRB- cord-018225-dozmy3lb 209 17 , , , cord-018225-dozmy3lb 209 18 12 12 CD cord-018225-dozmy3lb 209 19 patients patient NNS cord-018225-dozmy3lb 209 20 survived survive VBD cord-018225-dozmy3lb 209 21 . . . cord-018225-dozmy3lb 210 1 Deaths death NNS cord-018225-dozmy3lb 210 2 were be VBD cord-018225-dozmy3lb 210 3 due due JJ cord-018225-dozmy3lb 210 4 to to IN cord-018225-dozmy3lb 210 5 cerebral cerebral JJ cord-018225-dozmy3lb 210 6 edema edema NN cord-018225-dozmy3lb 210 7 ( ( -LRB- cord-018225-dozmy3lb 210 8 2 2 CD cord-018225-dozmy3lb 210 9 ) ) -RRB- cord-018225-dozmy3lb 210 10 , , , cord-018225-dozmy3lb 210 11 early early JJ cord-018225-dozmy3lb 210 12 graft graft NN cord-018225-dozmy3lb 210 13 failure failure NN cord-018225-dozmy3lb 210 14 ( ( -LRB- cord-018225-dozmy3lb 210 15 2 2 CD cord-018225-dozmy3lb 210 16 ) ) -RRB- cord-018225-dozmy3lb 210 17 , , , cord-018225-dozmy3lb 210 18 and and CC cord-018225-dozmy3lb 210 19 graft graft NN cord-018225-dozmy3lb 210 20 - - HYPH cord-018225-dozmy3lb 210 21 transmitted transmit VBN cord-018225-dozmy3lb 210 22 infection infection NN cord-018225-dozmy3lb 210 23 . . . cord-018225-dozmy3lb 211 1 Why why WRB cord-018225-dozmy3lb 211 2 it -PRON- PRP cord-018225-dozmy3lb 211 3 's be VBZ cord-018225-dozmy3lb 211 4 important important JJ cord-018225-dozmy3lb 212 1 This this DT cord-018225-dozmy3lb 212 2 paper paper NN cord-018225-dozmy3lb 212 3 was be VBD cord-018225-dozmy3lb 212 4 the the DT cord-018225-dozmy3lb 212 5 first first JJ cord-018225-dozmy3lb 212 6 large large JJ cord-018225-dozmy3lb 212 7 case case NN cord-018225-dozmy3lb 212 8 study study NN cord-018225-dozmy3lb 212 9 to to TO cord-018225-dozmy3lb 212 10 document document VB cord-018225-dozmy3lb 212 11 the the DT cord-018225-dozmy3lb 212 12 feasibility feasibility NN cord-018225-dozmy3lb 212 13 and and CC cord-018225-dozmy3lb 212 14 success success NN cord-018225-dozmy3lb 212 15 of of IN cord-018225-dozmy3lb 212 16 liver liver NN cord-018225-dozmy3lb 212 17 transplantation transplantation NN cord-018225-dozmy3lb 212 18 for for IN cord-018225-dozmy3lb 212 19 acute acute JJ cord-018225-dozmy3lb 212 20 liver liver NN cord-018225-dozmy3lb 212 21 failure failure NN cord-018225-dozmy3lb 212 22 . . . cord-018225-dozmy3lb 213 1 This this DT cord-018225-dozmy3lb 213 2 is be VBZ cord-018225-dozmy3lb 213 3 a a DT cord-018225-dozmy3lb 213 4 succinct succinct JJ cord-018225-dozmy3lb 213 5 review review NN cord-018225-dozmy3lb 213 6 of of IN cord-018225-dozmy3lb 213 7 17 17 CD cord-018225-dozmy3lb 213 8 patients patient NNS cord-018225-dozmy3lb 213 9 with with IN cord-018225-dozmy3lb 213 10 acute acute JJ cord-018225-dozmy3lb 213 11 liver liver NN cord-018225-dozmy3lb 213 12 failure failure NN cord-018225-dozmy3lb 213 13 who who WP cord-018225-dozmy3lb 213 14 underwent undergo VBD cord-018225-dozmy3lb 213 15 liver liver NN cord-018225-dozmy3lb 213 16 transplantation transplantation NN cord-018225-dozmy3lb 213 17 , , , cord-018225-dozmy3lb 213 18 with with IN cord-018225-dozmy3lb 213 19 appropriate appropriate JJ cord-018225-dozmy3lb 213 20 demographic demographic JJ cord-018225-dozmy3lb 213 21 , , , cord-018225-dozmy3lb 213 22 etiological etiological JJ cord-018225-dozmy3lb 213 23 , , , cord-018225-dozmy3lb 213 24 clinical clinical JJ cord-018225-dozmy3lb 213 25 , , , cord-018225-dozmy3lb 213 26 and and CC cord-018225-dozmy3lb 213 27 outcome outcome VB cord-018225-dozmy3lb 213 28 information information NN cord-018225-dozmy3lb 213 29 that that WDT cord-018225-dozmy3lb 213 30 remains remain VBZ cord-018225-dozmy3lb 213 31 relevant relevant JJ cord-018225-dozmy3lb 213 32 many many JJ cord-018225-dozmy3lb 213 33 years year NNS cord-018225-dozmy3lb 213 34 later later RB cord-018225-dozmy3lb 213 35 . . . cord-018225-dozmy3lb 214 1 No no DT cord-018225-dozmy3lb 214 2 case case NN cord-018225-dozmy3lb 214 3 control control NN cord-018225-dozmy3lb 214 4 data datum NNS cord-018225-dozmy3lb 214 5 are be VBP cord-018225-dozmy3lb 214 6 reported report VBN cord-018225-dozmy3lb 214 7 . . . cord-018225-dozmy3lb 215 1 Although although IN cord-018225-dozmy3lb 215 2 it -PRON- PRP cord-018225-dozmy3lb 215 3 is be VBZ cord-018225-dozmy3lb 215 4 stated state VBN cord-018225-dozmy3lb 215 5 that that IN cord-018225-dozmy3lb 215 6 transplantation transplantation NN cord-018225-dozmy3lb 215 7 was be VBD cord-018225-dozmy3lb 215 8 undertaken undertake VBN cord-018225-dozmy3lb 215 9 for for IN cord-018225-dozmy3lb 215 10 a a DT cord-018225-dozmy3lb 215 11 rapidly rapidly RB cord-018225-dozmy3lb 215 12 deteriorating deteriorate VBG cord-018225-dozmy3lb 215 13 neurological neurological JJ cord-018225-dozmy3lb 215 14 condition condition NN cord-018225-dozmy3lb 215 15 and and CC cord-018225-dozmy3lb 215 16 severe severe JJ cord-018225-dozmy3lb 215 17 coagulation coagulation NN cord-018225-dozmy3lb 215 18 disorders disorder NNS cord-018225-dozmy3lb 215 19 , , , cord-018225-dozmy3lb 215 20 the the DT cord-018225-dozmy3lb 215 21 outcome outcome NN cord-018225-dozmy3lb 215 22 of of IN cord-018225-dozmy3lb 215 23 patients patient NNS cord-018225-dozmy3lb 215 24 who who WP cord-018225-dozmy3lb 215 25 did do VBD cord-018225-dozmy3lb 215 26 not not RB cord-018225-dozmy3lb 215 27 meet meet VB cord-018225-dozmy3lb 215 28 these these DT cord-018225-dozmy3lb 215 29 criteria criterion NNS cord-018225-dozmy3lb 215 30 , , , cord-018225-dozmy3lb 215 31 or or CC cord-018225-dozmy3lb 215 32 who who WP cord-018225-dozmy3lb 215 33 met meet VBD cord-018225-dozmy3lb 215 34 the the DT cord-018225-dozmy3lb 215 35 criteria criterion NNS cord-018225-dozmy3lb 215 36 and and CC cord-018225-dozmy3lb 215 37 could could MD cord-018225-dozmy3lb 215 38 not not RB cord-018225-dozmy3lb 215 39 be be VB cord-018225-dozmy3lb 215 40 transplanted transplant VBN cord-018225-dozmy3lb 215 41 , , , cord-018225-dozmy3lb 215 42 is be VBZ cord-018225-dozmy3lb 215 43 not not RB cord-018225-dozmy3lb 215 44 reported report VBN cord-018225-dozmy3lb 215 45 . . . cord-018225-dozmy3lb 216 1 Hence hence RB cord-018225-dozmy3lb 216 2 , , , cord-018225-dozmy3lb 216 3 although although IN cord-018225-dozmy3lb 216 4 this this DT cord-018225-dozmy3lb 216 5 paper paper NN cord-018225-dozmy3lb 216 6 describes describe VBZ cord-018225-dozmy3lb 216 7 the the DT cord-018225-dozmy3lb 216 8 feasibility feasibility NN cord-018225-dozmy3lb 216 9 of of IN cord-018225-dozmy3lb 216 10 liver liver NN cord-018225-dozmy3lb 216 11 transplantation transplantation NN cord-018225-dozmy3lb 216 12 in in IN cord-018225-dozmy3lb 216 13 this this DT cord-018225-dozmy3lb 216 14 population population NN cord-018225-dozmy3lb 216 15 , , , cord-018225-dozmy3lb 216 16 it -PRON- PRP cord-018225-dozmy3lb 216 17 does do VBZ cord-018225-dozmy3lb 216 18 not not RB cord-018225-dozmy3lb 216 19 assess assess VB cord-018225-dozmy3lb 216 20 the the DT cord-018225-dozmy3lb 216 21 value value NN cord-018225-dozmy3lb 216 22 . . . cord-018225-dozmy3lb 217 1 Liver liver NN cord-018225-dozmy3lb 217 2 transplantation transplantation NN cord-018225-dozmy3lb 217 3 , , , cord-018225-dozmy3lb 217 4 as as IN cord-018225-dozmy3lb 217 5 described describe VBN cord-018225-dozmy3lb 217 6 in in IN cord-018225-dozmy3lb 217 7 this this DT cord-018225-dozmy3lb 217 8 case case NN cord-018225-dozmy3lb 217 9 series series NN cord-018225-dozmy3lb 217 10 , , , cord-018225-dozmy3lb 217 11 remains remain VBZ cord-018225-dozmy3lb 217 12 the the DT cord-018225-dozmy3lb 217 13 best good JJS cord-018225-dozmy3lb 217 14 chance chance NN cord-018225-dozmy3lb 217 15 of of IN cord-018225-dozmy3lb 217 16 survival survival NN cord-018225-dozmy3lb 217 17 for for IN cord-018225-dozmy3lb 217 18 the the DT cord-018225-dozmy3lb 217 19 majority majority NN cord-018225-dozmy3lb 217 20 of of IN cord-018225-dozmy3lb 217 21 patients patient NNS cord-018225-dozmy3lb 217 22 with with IN cord-018225-dozmy3lb 217 23 acute acute JJ cord-018225-dozmy3lb 217 24 liver liver NN cord-018225-dozmy3lb 217 25 failure failure NN cord-018225-dozmy3lb 217 26 . . . cord-018225-dozmy3lb 218 1 Although although IN cord-018225-dozmy3lb 218 2 criteria criterion NNS cord-018225-dozmy3lb 218 3 for for IN cord-018225-dozmy3lb 218 4 transplantation transplantation NN cord-018225-dozmy3lb 218 5 , , , cord-018225-dozmy3lb 218 6 and and CC cord-018225-dozmy3lb 218 7 aspects aspect NNS cord-018225-dozmy3lb 218 8 of of IN cord-018225-dozmy3lb 218 9 the the DT cord-018225-dozmy3lb 218 10 surgical surgical JJ cord-018225-dozmy3lb 218 11 technique technique NN cord-018225-dozmy3lb 218 12 and and CC cord-018225-dozmy3lb 218 13 postoperative postoperative JJ cord-018225-dozmy3lb 218 14 immunosuppression immunosuppression NN cord-018225-dozmy3lb 218 15 have have VBP cord-018225-dozmy3lb 218 16 developed develop VBN cord-018225-dozmy3lb 218 17 over over IN cord-018225-dozmy3lb 218 18 the the DT cord-018225-dozmy3lb 218 19 intervening intervene VBG cord-018225-dozmy3lb 218 20 years year NNS cord-018225-dozmy3lb 218 21 , , , cord-018225-dozmy3lb 218 22 orthotopic orthotopic JJ cord-018225-dozmy3lb 218 23 liver liver NN cord-018225-dozmy3lb 218 24 transplantation transplantation NN cord-018225-dozmy3lb 218 25 has have VBZ cord-018225-dozmy3lb 218 26 not not RB cord-018225-dozmy3lb 218 27 been be VBN cord-018225-dozmy3lb 218 28 superceded supercede VBN cord-018225-dozmy3lb 218 29 , , , cord-018225-dozmy3lb 218 30 and and CC cord-018225-dozmy3lb 218 31 should should MD cord-018225-dozmy3lb 218 32 be be VB cord-018225-dozmy3lb 218 33 considered consider VBN cord-018225-dozmy3lb 218 34 as as IN cord-018225-dozmy3lb 218 35 an an DT cord-018225-dozmy3lb 218 36 option option NN cord-018225-dozmy3lb 218 37 in in IN cord-018225-dozmy3lb 218 38 all all DT cord-018225-dozmy3lb 218 39 patients patient NNS cord-018225-dozmy3lb 218 40 with with IN cord-018225-dozmy3lb 218 41 acute acute JJ cord-018225-dozmy3lb 218 42 liver liver NN cord-018225-dozmy3lb 218 43 failure failure NN cord-018225-dozmy3lb 218 44 . . . cord-018225-dozmy3lb 219 1 Abstract abstract JJ cord-018225-dozmy3lb 219 2 BACKGROUND background NN cord-018225-dozmy3lb 219 3 . . . cord-018225-dozmy3lb 220 1 When when WRB cord-018225-dozmy3lb 220 2 administered administer VBN cord-018225-dozmy3lb 220 3 early early RB cord-018225-dozmy3lb 220 4 after after IN cord-018225-dozmy3lb 220 5 an an DT cord-018225-dozmy3lb 220 6 overdose overdose NN cord-018225-dozmy3lb 220 7 of of IN cord-018225-dozmy3lb 220 8 acetaminophen acetaminophen NN cord-018225-dozmy3lb 220 9 , , , cord-018225-dozmy3lb 220 10 intravenous intravenous JJ cord-018225-dozmy3lb 220 11 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 220 12 prevents prevent VBZ cord-018225-dozmy3lb 220 13 hepatic hepatic JJ cord-018225-dozmy3lb 220 14 necrosis necrosis NN cord-018225-dozmy3lb 220 15 by by IN cord-018225-dozmy3lb 220 16 replenishing replenish VBG cord-018225-dozmy3lb 220 17 reduced reduce VBN cord-018225-dozmy3lb 220 18 stores store NNS cord-018225-dozmy3lb 220 19 of of IN cord-018225-dozmy3lb 220 20 glutathione glutathione NN cord-018225-dozmy3lb 220 21 . . . cord-018225-dozmy3lb 221 1 How how WRB cord-018225-dozmy3lb 221 2 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 221 3 improves improve VBZ cord-018225-dozmy3lb 221 4 the the DT cord-018225-dozmy3lb 221 5 survival survival NN cord-018225-dozmy3lb 221 6 of of IN cord-018225-dozmy3lb 221 7 patients patient NNS cord-018225-dozmy3lb 221 8 with with IN cord-018225-dozmy3lb 221 9 established established JJ cord-018225-dozmy3lb 221 10 liver liver NN cord-018225-dozmy3lb 221 11 damage damage NN cord-018225-dozmy3lb 221 12 induced induce VBN cord-018225-dozmy3lb 221 13 by by IN cord-018225-dozmy3lb 221 14 acetaminophen acetaminophen NN cord-018225-dozmy3lb 221 15 , , , cord-018225-dozmy3lb 221 16 however however RB cord-018225-dozmy3lb 221 17 , , , cord-018225-dozmy3lb 221 18 is be VBZ cord-018225-dozmy3lb 221 19 unknown unknown JJ cord-018225-dozmy3lb 221 20 . . . cord-018225-dozmy3lb 222 1 This this DT cord-018225-dozmy3lb 222 2 study study NN cord-018225-dozmy3lb 222 3 was be VBD cord-018225-dozmy3lb 222 4 undertaken undertake VBN cord-018225-dozmy3lb 222 5 to to TO cord-018225-dozmy3lb 222 6 determine determine VB cord-018225-dozmy3lb 222 7 whether whether IN cord-018225-dozmy3lb 222 8 the the DT cord-018225-dozmy3lb 222 9 beneficial beneficial JJ cord-018225-dozmy3lb 222 10 effect effect NN cord-018225-dozmy3lb 222 11 of of IN cord-018225-dozmy3lb 222 12 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 222 13 under under IN cord-018225-dozmy3lb 222 14 such such JJ cord-018225-dozmy3lb 222 15 circumstances circumstance NNS cord-018225-dozmy3lb 222 16 could could MD cord-018225-dozmy3lb 222 17 be be VB cord-018225-dozmy3lb 222 18 due due JJ cord-018225-dozmy3lb 222 19 to to IN cord-018225-dozmy3lb 222 20 enhancement enhancement NN cord-018225-dozmy3lb 222 21 of of IN cord-018225-dozmy3lb 222 22 oxygen oxygen NN cord-018225-dozmy3lb 222 23 delivery delivery NN cord-018225-dozmy3lb 222 24 and and CC cord-018225-dozmy3lb 222 25 consumption consumption NN cord-018225-dozmy3lb 222 26 . . . cord-018225-dozmy3lb 223 1 METHODS METHODS NNP cord-018225-dozmy3lb 223 2 . . . cord-018225-dozmy3lb 224 1 We -PRON- PRP cord-018225-dozmy3lb 224 2 studied study VBD cord-018225-dozmy3lb 224 3 the the DT cord-018225-dozmy3lb 224 4 effect effect NN cord-018225-dozmy3lb 224 5 of of IN cord-018225-dozmy3lb 224 6 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 224 7 on on IN cord-018225-dozmy3lb 224 8 systemic systemic JJ cord-018225-dozmy3lb 224 9 hemodynamics hemodynamic NNS cord-018225-dozmy3lb 224 10 and and CC cord-018225-dozmy3lb 224 11 oxygen oxygen NN cord-018225-dozmy3lb 224 12 transport transport NN cord-018225-dozmy3lb 224 13 in in IN cord-018225-dozmy3lb 224 14 12 12 CD cord-018225-dozmy3lb 224 15 patients patient NNS cord-018225-dozmy3lb 224 16 with with IN cord-018225-dozmy3lb 224 17 acetaminophen acetaminophen NN cord-018225-dozmy3lb 224 18 - - HYPH cord-018225-dozmy3lb 224 19 induced induce VBN cord-018225-dozmy3lb 224 20 fulminant fulminant JJ cord-018225-dozmy3lb 224 21 hepatic hepatic JJ cord-018225-dozmy3lb 224 22 failure failure NN cord-018225-dozmy3lb 224 23 , , , cord-018225-dozmy3lb 224 24 and and CC cord-018225-dozmy3lb 224 25 8 8 CD cord-018225-dozmy3lb 224 26 patients patient NNS cord-018225-dozmy3lb 224 27 with with IN cord-018225-dozmy3lb 224 28 acute acute JJ cord-018225-dozmy3lb 224 29 liver liver NN cord-018225-dozmy3lb 224 30 failure failure NN cord-018225-dozmy3lb 224 31 from from IN cord-018225-dozmy3lb 224 32 other other JJ cord-018225-dozmy3lb 224 33 causes cause NNS cord-018225-dozmy3lb 224 34 . . . cord-018225-dozmy3lb 225 1 The the DT cord-018225-dozmy3lb 225 2 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 225 3 was be VBD cord-018225-dozmy3lb 225 4 given give VBN cord-018225-dozmy3lb 225 5 in in IN cord-018225-dozmy3lb 225 6 a a DT cord-018225-dozmy3lb 225 7 dose dose NN cord-018225-dozmy3lb 225 8 of of IN cord-018225-dozmy3lb 225 9 150 150 CD cord-018225-dozmy3lb 225 10 mg mg NNP cord-018225-dozmy3lb 225 11 / / SYM cord-018225-dozmy3lb 225 12 kg kg NNP cord-018225-dozmy3lb 225 13 in in IN cord-018225-dozmy3lb 225 14 250 250 CD cord-018225-dozmy3lb 225 15 ml ml NNS cord-018225-dozmy3lb 225 16 of of IN cord-018225-dozmy3lb 225 17 5 5 CD cord-018225-dozmy3lb 225 18 % % NN cord-018225-dozmy3lb 225 19 dextrose dextrose NN cord-018225-dozmy3lb 225 20 over over IN cord-018225-dozmy3lb 225 21 a a DT cord-018225-dozmy3lb 225 22 period period NN cord-018225-dozmy3lb 225 23 of of IN cord-018225-dozmy3lb 225 24 15 15 CD cord-018225-dozmy3lb 225 25 minutes minute NNS cord-018225-dozmy3lb 225 26 , , , cord-018225-dozmy3lb 225 27 and and CC cord-018225-dozmy3lb 225 28 then then RB cord-018225-dozmy3lb 225 29 in in IN cord-018225-dozmy3lb 225 30 a a DT cord-018225-dozmy3lb 225 31 dose dose NN cord-018225-dozmy3lb 225 32 of of IN cord-018225-dozmy3lb 225 33 50 50 CD cord-018225-dozmy3lb 225 34 mg mg NNP cord-018225-dozmy3lb 225 35 / / SYM cord-018225-dozmy3lb 225 36 kg kg NNP cord-018225-dozmy3lb 225 37 in in IN cord-018225-dozmy3lb 225 38 500 500 CD cord-018225-dozmy3lb 225 39 ml ml NNS cord-018225-dozmy3lb 225 40 of of IN cord-018225-dozmy3lb 225 41 5 5 CD cord-018225-dozmy3lb 225 42 % % NN cord-018225-dozmy3lb 225 43 dextrose dextrose NN cord-018225-dozmy3lb 225 44 over over IN cord-018225-dozmy3lb 225 45 a a DT cord-018225-dozmy3lb 225 46 period period NN cord-018225-dozmy3lb 225 47 of of IN cord-018225-dozmy3lb 225 48 4 4 CD cord-018225-dozmy3lb 225 49 hours hour NNS cord-018225-dozmy3lb 225 50 ; ; : cord-018225-dozmy3lb 225 51 measurements measurement NNS cord-018225-dozmy3lb 225 52 were be VBD cord-018225-dozmy3lb 225 53 made make VBN cord-018225-dozmy3lb 225 54 before before IN cord-018225-dozmy3lb 225 55 treatment treatment NN cord-018225-dozmy3lb 225 56 began begin VBD cord-018225-dozmy3lb 225 57 , , , cord-018225-dozmy3lb 225 58 and and CC cord-018225-dozmy3lb 225 59 after after IN cord-018225-dozmy3lb 225 60 30 30 CD cord-018225-dozmy3lb 225 61 minutes minute NNS cord-018225-dozmy3lb 225 62 of of IN cord-018225-dozmy3lb 225 63 the the DT cord-018225-dozmy3lb 225 64 regimen regimen NN cord-018225-dozmy3lb 225 65 . . . cord-018225-dozmy3lb 226 1 RESULTS result NNS cord-018225-dozmy3lb 226 2 . . . cord-018225-dozmy3lb 227 1 In in IN cord-018225-dozmy3lb 227 2 the the DT cord-018225-dozmy3lb 227 3 patients patient NNS cord-018225-dozmy3lb 227 4 with with IN cord-018225-dozmy3lb 227 5 acetaminophen acetaminophen NN cord-018225-dozmy3lb 227 6 - - HYPH cord-018225-dozmy3lb 227 7 induced induce VBN cord-018225-dozmy3lb 227 8 liver liver NN cord-018225-dozmy3lb 227 9 failure failure NN cord-018225-dozmy3lb 227 10 , , , cord-018225-dozmy3lb 227 11 the the DT cord-018225-dozmy3lb 227 12 infusion infusion NN cord-018225-dozmy3lb 227 13 of of IN cord-018225-dozmy3lb 227 14 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 227 15 resulted result VBD cord-018225-dozmy3lb 227 16 in in IN cord-018225-dozmy3lb 227 17 an an DT cord-018225-dozmy3lb 227 18 increase increase NN cord-018225-dozmy3lb 227 19 in in IN cord-018225-dozmy3lb 227 20 mean mean JJ cord-018225-dozmy3lb 227 21 oxygen oxygen NN cord-018225-dozmy3lb 227 22 delivery delivery NN cord-018225-dozmy3lb 227 23 from from IN cord-018225-dozmy3lb 227 24 856 856 CD cord-018225-dozmy3lb 227 25 to to TO cord-018225-dozmy3lb 227 26 975 975 CD cord-018225-dozmy3lb 227 27 ml ml NN cord-018225-dozmy3lb 227 28 / / SYM cord-018225-dozmy3lb 227 29 min min NN cord-018225-dozmy3lb 228 1 /m /m NNP cord-018225-dozmy3lb 228 2 2 2 CD cord-018225-dozmy3lb 229 1 ( ( -LRB- cord-018225-dozmy3lb 229 2 p p NN cord-018225-dozmy3lb 229 3 = = SYM cord-018225-dozmy3lb 229 4 0.0036 0.0036 CD cord-018225-dozmy3lb 229 5 ) ) -RRB- cord-018225-dozmy3lb 229 6 , , , cord-018225-dozmy3lb 229 7 due due IN cord-018225-dozmy3lb 229 8 to to IN cord-018225-dozmy3lb 229 9 an an DT cord-018225-dozmy3lb 229 10 increase increase NN cord-018225-dozmy3lb 229 11 in in IN cord-018225-dozmy3lb 229 12 the the DT cord-018225-dozmy3lb 229 13 cardiac cardiac JJ cord-018225-dozmy3lb 229 14 index index NN cord-018225-dozmy3lb 229 15 from from IN cord-018225-dozmy3lb 229 16 5.6 5.6 CD cord-018225-dozmy3lb 229 17 to to TO cord-018225-dozmy3lb 229 18 6.7 6.7 CD cord-018225-dozmy3lb 229 19 mm mm NN cord-018225-dozmy3lb 229 20 / / SYM cord-018225-dozmy3lb 229 21 m m NN cord-018225-dozmy3lb 229 22 2 2 CD cord-018225-dozmy3lb 229 23 ( ( -LRB- cord-018225-dozmy3lb 229 24 p p NN cord-018225-dozmy3lb 229 25 = = SYM cord-018225-dozmy3lb 229 26 0.0021 0.0021 CD cord-018225-dozmy3lb 229 27 ) ) -RRB- cord-018225-dozmy3lb 229 28 . . . cord-018225-dozmy3lb 230 1 Mean mean JJ cord-018225-dozmy3lb 230 2 arterial arterial JJ cord-018225-dozmy3lb 230 3 pressure pressure NN cord-018225-dozmy3lb 230 4 rose rise VBD cord-018225-dozmy3lb 230 5 from from IN cord-018225-dozmy3lb 230 6 88 88 CD cord-018225-dozmy3lb 230 7 to to TO cord-018225-dozmy3lb 230 8 95 95 CD cord-018225-dozmy3lb 230 9 mmHg mmHg NNS cord-018225-dozmy3lb 230 10 ( ( -LRB- cord-018225-dozmy3lb 230 11 p p NN cord-018225-dozmy3lb 230 12 = = SYM cord-018225-dozmy3lb 230 13 0.0054 0.0054 CD cord-018225-dozmy3lb 230 14 ) ) -RRB- cord-018225-dozmy3lb 230 15 , , , cord-018225-dozmy3lb 230 16 despite despite IN cord-018225-dozmy3lb 230 17 a a DT cord-018225-dozmy3lb 230 18 decrease decrease NN cord-018225-dozmy3lb 230 19 in in IN cord-018225-dozmy3lb 230 20 systemic systemic JJ cord-018225-dozmy3lb 230 21 vascular vascular JJ cord-018225-dozmy3lb 230 22 resistance resistance NN cord-018225-dozmy3lb 230 23 from from IN cord-018225-dozmy3lb 230 24 1296 1296 CD cord-018225-dozmy3lb 230 25 to to IN cord-018225-dozmy3lb 230 26 1113 1113 CD cord-018225-dozmy3lb 230 27 dyn.sec.cm dyn.sec.cm NNP cord-018225-dozmy3lb 230 28 -5 -5 NNP cord-018225-dozmy3lb 230 29 per per IN cord-018225-dozmy3lb 230 30 square square JJ cord-018225-dozmy3lb 230 31 meter meter NN cord-018225-dozmy3lb 230 32 ( ( -LRB- cord-018225-dozmy3lb 230 33 p p NN cord-018225-dozmy3lb 230 34 = = SYM cord-018225-dozmy3lb 230 35 0.027 0.027 CD cord-018225-dozmy3lb 230 36 ) ) -RRB- cord-018225-dozmy3lb 230 37 . . . cord-018225-dozmy3lb 231 1 There there EX cord-018225-dozmy3lb 231 2 was be VBD cord-018225-dozmy3lb 231 3 an an DT cord-018225-dozmy3lb 231 4 increase increase NN cord-018225-dozmy3lb 231 5 in in IN cord-018225-dozmy3lb 231 6 oxygen oxygen NN cord-018225-dozmy3lb 231 7 consumption consumption NN cord-018225-dozmy3lb 231 8 from from IN cord-018225-dozmy3lb 231 9 127 127 CD cord-018225-dozmy3lb 231 10 to to IN cord-018225-dozmy3lb 231 11 184 184 CD cord-018225-dozmy3lb 232 1 ml ml NNP cord-018225-dozmy3lb 232 2 / / SYM cord-018225-dozmy3lb 232 3 min min NN cord-018225-dozmy3lb 233 1 /m /m NNP cord-018225-dozmy3lb 233 2 2 2 CD cord-018225-dozmy3lb 233 3 ( ( -LRB- cord-018225-dozmy3lb 233 4 p p NN cord-018225-dozmy3lb 233 5 = = SYM cord-018225-dozmy3lb 233 6 0.0007 0.0007 CD cord-018225-dozmy3lb 233 7 ) ) -RRB- cord-018225-dozmy3lb 233 8 associated associate VBN cord-018225-dozmy3lb 233 9 with with IN cord-018225-dozmy3lb 233 10 an an DT cord-018225-dozmy3lb 233 11 increase increase NN cord-018225-dozmy3lb 233 12 in in IN cord-018225-dozmy3lb 233 13 the the DT cord-018225-dozmy3lb 233 14 oxygen oxygen NN cord-018225-dozmy3lb 233 15 - - HYPH cord-018225-dozmy3lb 233 16 extraction extraction NN cord-018225-dozmy3lb 233 17 ratio ratio NN cord-018225-dozmy3lb 233 18 from from IN cord-018225-dozmy3lb 233 19 16 16 CD cord-018225-dozmy3lb 233 20 to to TO cord-018225-dozmy3lb 233 21 21 21 CD cord-018225-dozmy3lb 233 22 percent percent NN cord-018225-dozmy3lb 233 23 ( ( -LRB- cord-018225-dozmy3lb 233 24 p p NN cord-018225-dozmy3lb 233 25 = = SYM cord-018225-dozmy3lb 233 26 0.022 0.022 CD cord-018225-dozmy3lb 233 27 ) ) -RRB- cord-018225-dozmy3lb 233 28 . . . cord-018225-dozmy3lb 234 1 The the DT cord-018225-dozmy3lb 234 2 effects effect NNS cord-018225-dozmy3lb 234 3 in in IN cord-018225-dozmy3lb 234 4 the the DT cord-018225-dozmy3lb 234 5 patients patient NNS cord-018225-dozmy3lb 234 6 with with IN cord-018225-dozmy3lb 234 7 acute acute JJ cord-018225-dozmy3lb 234 8 liver liver NN cord-018225-dozmy3lb 234 9 failure failure NN cord-018225-dozmy3lb 234 10 from from IN cord-018225-dozmy3lb 234 11 other other JJ cord-018225-dozmy3lb 234 12 causes cause NNS cord-018225-dozmy3lb 234 13 were be VBD cord-018225-dozmy3lb 234 14 similar similar JJ cord-018225-dozmy3lb 234 15 . . . cord-018225-dozmy3lb 235 1 CONCLUSIONS conclusion NNS cord-018225-dozmy3lb 235 2 . . . cord-018225-dozmy3lb 236 1 The the DT cord-018225-dozmy3lb 236 2 increase increase NN cord-018225-dozmy3lb 236 3 in in IN cord-018225-dozmy3lb 236 4 oxygen oxygen NN cord-018225-dozmy3lb 236 5 delivery delivery NN cord-018225-dozmy3lb 236 6 and and CC cord-018225-dozmy3lb 236 7 consumption consumption NN cord-018225-dozmy3lb 236 8 in in IN cord-018225-dozmy3lb 236 9 response response NN cord-018225-dozmy3lb 236 10 to to IN cord-018225-dozmy3lb 236 11 acetylcysteine acetylcysteine NNP cord-018225-dozmy3lb 236 12 may may MD cord-018225-dozmy3lb 236 13 account account VB cord-018225-dozmy3lb 236 14 for for IN cord-018225-dozmy3lb 236 15 its -PRON- PRP$ cord-018225-dozmy3lb 236 16 beneficial beneficial JJ cord-018225-dozmy3lb 236 17 effect effect NN cord-018225-dozmy3lb 236 18 on on IN cord-018225-dozmy3lb 236 19 survival survival NN cord-018225-dozmy3lb 236 20 in in IN cord-018225-dozmy3lb 236 21 patients patient NNS cord-018225-dozmy3lb 236 22 with with IN cord-018225-dozmy3lb 236 23 fulminant fulminant JJ cord-018225-dozmy3lb 236 24 hepatic hepatic JJ cord-018225-dozmy3lb 236 25 failure failure NN cord-018225-dozmy3lb 236 26 induced induce VBN cord-018225-dozmy3lb 236 27 by by IN cord-018225-dozmy3lb 236 28 acetaminophen acetaminophen NN cord-018225-dozmy3lb 236 29 . . . cord-018225-dozmy3lb 237 1 The the DT cord-018225-dozmy3lb 237 2 effects effect NNS cord-018225-dozmy3lb 237 3 of of IN cord-018225-dozmy3lb 237 4 intravenous intravenous JJ cord-018225-dozmy3lb 237 5 n n NN cord-018225-dozmy3lb 237 6 - - HYPH cord-018225-dozmy3lb 237 7 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 237 8 on on IN cord-018225-dozmy3lb 237 9 systemic systemic JJ cord-018225-dozmy3lb 237 10 hemodynamics hemodynamic NNS cord-018225-dozmy3lb 237 11 and and CC cord-018225-dozmy3lb 237 12 oxygen oxygen NN cord-018225-dozmy3lb 237 13 transport transport NN cord-018225-dozmy3lb 237 14 were be VBD cord-018225-dozmy3lb 237 15 studied study VBN cord-018225-dozmy3lb 237 16 in in IN cord-018225-dozmy3lb 237 17 12 12 CD cord-018225-dozmy3lb 237 18 patients patient NNS cord-018225-dozmy3lb 237 19 with with IN cord-018225-dozmy3lb 237 20 paracetamol paracetamol NN cord-018225-dozmy3lb 237 21 - - HYPH cord-018225-dozmy3lb 237 22 induced induce VBN cord-018225-dozmy3lb 237 23 acute acute JJ cord-018225-dozmy3lb 237 24 liver liver NN cord-018225-dozmy3lb 237 25 failure failure NN cord-018225-dozmy3lb 237 26 , , , cord-018225-dozmy3lb 237 27 and and CC cord-018225-dozmy3lb 237 28 eight eight CD cord-018225-dozmy3lb 237 29 patients patient NNS cord-018225-dozmy3lb 237 30 with with IN cord-018225-dozmy3lb 237 31 acute acute JJ cord-018225-dozmy3lb 237 32 liver liver NN cord-018225-dozmy3lb 237 33 failure failure NN cord-018225-dozmy3lb 237 34 from from IN cord-018225-dozmy3lb 237 35 other other JJ cord-018225-dozmy3lb 237 36 causes cause NNS cord-018225-dozmy3lb 237 37 . . . cord-018225-dozmy3lb 238 1 Measurements measurement NNS cord-018225-dozmy3lb 238 2 were be VBD cord-018225-dozmy3lb 238 3 made make VBN cord-018225-dozmy3lb 238 4 before before IN cord-018225-dozmy3lb 238 5 a a DT cord-018225-dozmy3lb 238 6 bolus bolus NN cord-018225-dozmy3lb 238 7 dose dose NN cord-018225-dozmy3lb 238 8 of of IN cord-018225-dozmy3lb 238 9 150 150 CD cord-018225-dozmy3lb 238 10 mg mg NNP cord-018225-dozmy3lb 238 11 / / SYM cord-018225-dozmy3lb 238 12 kg kg NNP cord-018225-dozmy3lb 238 13 of of IN cord-018225-dozmy3lb 238 14 n n NN cord-018225-dozmy3lb 238 15 - - HYPH cord-018225-dozmy3lb 238 16 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 238 17 given give VBN cord-018225-dozmy3lb 238 18 over over IN cord-018225-dozmy3lb 238 19 15 15 CD cord-018225-dozmy3lb 238 20 minutes minute NNS cord-018225-dozmy3lb 238 21 , , , cord-018225-dozmy3lb 238 22 and and CC cord-018225-dozmy3lb 238 23 30 30 CD cord-018225-dozmy3lb 238 24 minutes minute NNS cord-018225-dozmy3lb 238 25 after after IN cord-018225-dozmy3lb 238 26 commencement commencement NN cord-018225-dozmy3lb 238 27 of of IN cord-018225-dozmy3lb 238 28 an an DT cord-018225-dozmy3lb 238 29 infusion infusion NN cord-018225-dozmy3lb 238 30 of of IN cord-018225-dozmy3lb 238 31 50 50 CD cord-018225-dozmy3lb 238 32 mg mg NNP cord-018225-dozmy3lb 238 33 / / SYM cord-018225-dozmy3lb 238 34 kg kg NNS cord-018225-dozmy3lb 238 35 of of IN cord-018225-dozmy3lb 238 36 n n NN cord-018225-dozmy3lb 238 37 - - HYPH cord-018225-dozmy3lb 238 38 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 238 39 given give VBN cord-018225-dozmy3lb 238 40 over over IN cord-018225-dozmy3lb 238 41 4 4 CD cord-018225-dozmy3lb 238 42 hours hour NNS cord-018225-dozmy3lb 238 43 . . . cord-018225-dozmy3lb 239 1 The the DT cord-018225-dozmy3lb 239 2 findings finding NNS cord-018225-dozmy3lb 239 3 were be VBD cord-018225-dozmy3lb 239 4 that that IN cord-018225-dozmy3lb 239 5 in in IN cord-018225-dozmy3lb 239 6 patients patient NNS cord-018225-dozmy3lb 239 7 with with IN cord-018225-dozmy3lb 239 8 paracetamol paracetamol NN cord-018225-dozmy3lb 239 9 - - HYPH cord-018225-dozmy3lb 239 10 induced induce VBN cord-018225-dozmy3lb 239 11 acute acute JJ cord-018225-dozmy3lb 239 12 liver liver NN cord-018225-dozmy3lb 239 13 failure failure NN cord-018225-dozmy3lb 239 14 , , , cord-018225-dozmy3lb 239 15 infusion infusion NN cord-018225-dozmy3lb 239 16 of of IN cord-018225-dozmy3lb 239 17 n n NN cord-018225-dozmy3lb 239 18 - - HYPH cord-018225-dozmy3lb 239 19 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 239 20 resulted result VBD cord-018225-dozmy3lb 239 21 in in IN cord-018225-dozmy3lb 239 22 an an DT cord-018225-dozmy3lb 239 23 increase increase NN cord-018225-dozmy3lb 239 24 in in IN cord-018225-dozmy3lb 239 25 mean mean JJ cord-018225-dozmy3lb 239 26 oxygen oxygen NN cord-018225-dozmy3lb 239 27 delivery delivery NN cord-018225-dozmy3lb 239 28 from from IN cord-018225-dozmy3lb 239 29 856 856 CD cord-018225-dozmy3lb 239 30 to to TO cord-018225-dozmy3lb 239 31 975 975 CD cord-018225-dozmy3lb 239 32 ml ml NN cord-018225-dozmy3lb 239 33 / / SYM cord-018225-dozmy3lb 239 34 min min NN cord-018225-dozmy3lb 239 35 / / SYM cord-018225-dozmy3lb 239 36 m m NNP cord-018225-dozmy3lb 239 37 2 2 CD cord-018225-dozmy3lb 239 38 , , , cord-018225-dozmy3lb 239 39 resulting result VBG cord-018225-dozmy3lb 239 40 mainly mainly RB cord-018225-dozmy3lb 239 41 from from IN cord-018225-dozmy3lb 239 42 an an DT cord-018225-dozmy3lb 239 43 increase increase NN cord-018225-dozmy3lb 239 44 in in IN cord-018225-dozmy3lb 239 45 the the DT cord-018225-dozmy3lb 239 46 mean mean JJ cord-018225-dozmy3lb 239 47 cardiac cardiac JJ cord-018225-dozmy3lb 239 48 index index NN cord-018225-dozmy3lb 239 49 by by IN cord-018225-dozmy3lb 239 50 approximately approximately RB cord-018225-dozmy3lb 239 51 20 20 CD cord-018225-dozmy3lb 239 52 % % NN cord-018225-dozmy3lb 239 53 ( ( -LRB- cord-018225-dozmy3lb 239 54 5.6 5.6 CD cord-018225-dozmy3lb 239 55 to to TO cord-018225-dozmy3lb 239 56 6.7 6.7 CD cord-018225-dozmy3lb 239 57 L l NN cord-018225-dozmy3lb 239 58 / / SYM cord-018225-dozmy3lb 239 59 min min NN cord-018225-dozmy3lb 239 60 / / SYM cord-018225-dozmy3lb 239 61 m m NNP cord-018225-dozmy3lb 239 62 2 2 CD cord-018225-dozmy3lb 239 63 ) ) -RRB- cord-018225-dozmy3lb 239 64 . . . cord-018225-dozmy3lb 240 1 Mean mean JJ cord-018225-dozmy3lb 240 2 arterial arterial JJ cord-018225-dozmy3lb 240 3 pressure pressure NN cord-018225-dozmy3lb 240 4 increased increase VBD cord-018225-dozmy3lb 240 5 from from IN cord-018225-dozmy3lb 240 6 88 88 CD cord-018225-dozmy3lb 240 7 to to TO cord-018225-dozmy3lb 240 8 95 95 CD cord-018225-dozmy3lb 240 9 mmHg mmHg NNS cord-018225-dozmy3lb 240 10 despite despite IN cord-018225-dozmy3lb 240 11 a a DT cord-018225-dozmy3lb 240 12 decrease decrease NN cord-018225-dozmy3lb 240 13 in in IN cord-018225-dozmy3lb 240 14 the the DT cord-018225-dozmy3lb 240 15 mean mean JJ cord-018225-dozmy3lb 240 16 systemic systemic JJ cord-018225-dozmy3lb 240 17 vascular vascular JJ cord-018225-dozmy3lb 240 18 resistance resistance NN cord-018225-dozmy3lb 240 19 from from IN cord-018225-dozmy3lb 240 20 1296 1296 CD cord-018225-dozmy3lb 240 21 to to IN cord-018225-dozmy3lb 240 22 1113 1113 CD cord-018225-dozmy3lb 240 23 dyn dyn NNP cord-018225-dozmy3lb 240 24 / / SYM cord-018225-dozmy3lb 240 25 sec sec NNP cord-018225-dozmy3lb 240 26 / / SYM cord-018225-dozmy3lb 240 27 cm cm NNP cord-018225-dozmy3lb 240 28 -5 -5 NNP cord-018225-dozmy3lb 240 29 . . . cord-018225-dozmy3lb 241 1 In in IN cord-018225-dozmy3lb 241 2 patients patient NNS cord-018225-dozmy3lb 241 3 with with IN cord-018225-dozmy3lb 241 4 acute acute JJ cord-018225-dozmy3lb 241 5 liver liver NN cord-018225-dozmy3lb 241 6 failure failure NN cord-018225-dozmy3lb 241 7 from from IN cord-018225-dozmy3lb 241 8 other other JJ cord-018225-dozmy3lb 241 9 causes cause NNS cord-018225-dozmy3lb 241 10 , , , cord-018225-dozmy3lb 241 11 the the DT cord-018225-dozmy3lb 241 12 effects effect NNS cord-018225-dozmy3lb 241 13 of of IN cord-018225-dozmy3lb 241 14 n n NN cord-018225-dozmy3lb 241 15 - - HYPH cord-018225-dozmy3lb 241 16 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 241 17 were be VBD cord-018225-dozmy3lb 241 18 similar similar JJ cord-018225-dozmy3lb 241 19 but but CC cord-018225-dozmy3lb 241 20 less less RBR cord-018225-dozmy3lb 241 21 marked marked JJ cord-018225-dozmy3lb 241 22 , , , cord-018225-dozmy3lb 241 23 and and CC cord-018225-dozmy3lb 241 24 there there EX cord-018225-dozmy3lb 241 25 were be VBD cord-018225-dozmy3lb 241 26 significant significant JJ cord-018225-dozmy3lb 241 27 changes change NNS cord-018225-dozmy3lb 241 28 ( ( -LRB- cord-018225-dozmy3lb 241 29 increases increase NNS cord-018225-dozmy3lb 241 30 ) ) -RRB- cord-018225-dozmy3lb 241 31 only only RB cord-018225-dozmy3lb 241 32 for for IN cord-018225-dozmy3lb 241 33 oxygen oxygen NN cord-018225-dozmy3lb 241 34 consumption consumption NN cord-018225-dozmy3lb 241 35 and and CC cord-018225-dozmy3lb 241 36 oxygen oxygen NN cord-018225-dozmy3lb 241 37 extraction extraction NN cord-018225-dozmy3lb 241 38 ratio ratio NN cord-018225-dozmy3lb 241 39 . . . cord-018225-dozmy3lb 242 1 Each each DT cord-018225-dozmy3lb 242 2 patient patient NN cord-018225-dozmy3lb 242 3 had have VBD cord-018225-dozmy3lb 242 4 similar similar JJ cord-018225-dozmy3lb 242 5 measurements measurement NNS cord-018225-dozmy3lb 242 6 performed perform VBN cord-018225-dozmy3lb 242 7 before before RB cord-018225-dozmy3lb 242 8 and and CC cord-018225-dozmy3lb 242 9 during during IN cord-018225-dozmy3lb 242 10 an an DT cord-018225-dozmy3lb 242 11 infusion infusion NN cord-018225-dozmy3lb 242 12 of of IN cord-018225-dozmy3lb 242 13 prostacyclin prostacyclin NNP cord-018225-dozmy3lb 242 14 at at IN cord-018225-dozmy3lb 242 15 a a DT cord-018225-dozmy3lb 242 16 rate rate NN cord-018225-dozmy3lb 242 17 of of IN cord-018225-dozmy3lb 242 18 5 5 CD cord-018225-dozmy3lb 242 19 ng ng NN cord-018225-dozmy3lb 242 20 / / SYM cord-018225-dozmy3lb 242 21 kg kg NNP cord-018225-dozmy3lb 242 22 , , , cord-018225-dozmy3lb 242 23 and and CC cord-018225-dozmy3lb 242 24 again again RB cord-018225-dozmy3lb 242 25 when when WRB cord-018225-dozmy3lb 242 26 n n NN cord-018225-dozmy3lb 242 27 - - HYPH cord-018225-dozmy3lb 242 28 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 242 29 and and CC cord-018225-dozmy3lb 242 30 prostacyclin prostacyclin NNP cord-018225-dozmy3lb 242 31 were be VBD cord-018225-dozmy3lb 242 32 infused infuse VBN cord-018225-dozmy3lb 242 33 simultaneously simultaneously RB cord-018225-dozmy3lb 242 34 . . . cord-018225-dozmy3lb 243 1 The the DT cord-018225-dozmy3lb 243 2 effects effect NNS cord-018225-dozmy3lb 243 3 of of IN cord-018225-dozmy3lb 243 4 prostacyclin prostacyclin NNP cord-018225-dozmy3lb 243 5 were be VBD cord-018225-dozmy3lb 243 6 similar similar JJ cord-018225-dozmy3lb 243 7 to to IN cord-018225-dozmy3lb 243 8 those those DT cord-018225-dozmy3lb 243 9 of of IN cord-018225-dozmy3lb 243 10 n n NN cord-018225-dozmy3lb 243 11 - - HYPH cord-018225-dozmy3lb 243 12 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 243 13 , , , cord-018225-dozmy3lb 243 14 but but CC cord-018225-dozmy3lb 243 15 there there EX cord-018225-dozmy3lb 243 16 was be VBD cord-018225-dozmy3lb 243 17 a a DT cord-018225-dozmy3lb 243 18 decrease decrease NN cord-018225-dozmy3lb 243 19 in in IN cord-018225-dozmy3lb 243 20 mean mean JJ cord-018225-dozmy3lb 243 21 arterial arterial JJ cord-018225-dozmy3lb 243 22 pressure pressure NN cord-018225-dozmy3lb 243 23 rather rather RB cord-018225-dozmy3lb 243 24 than than IN cord-018225-dozmy3lb 243 25 an an DT cord-018225-dozmy3lb 243 26 increase increase NN cord-018225-dozmy3lb 243 27 , , , cord-018225-dozmy3lb 243 28 and and CC cord-018225-dozmy3lb 243 29 a a DT cord-018225-dozmy3lb 243 30 much much RB cord-018225-dozmy3lb 243 31 smaller small JJR cord-018225-dozmy3lb 243 32 increase increase NN cord-018225-dozmy3lb 243 33 in in IN cord-018225-dozmy3lb 243 34 oxygen oxygen NN cord-018225-dozmy3lb 243 35 extraction extraction NN cord-018225-dozmy3lb 243 36 . . . cord-018225-dozmy3lb 244 1 Four four CD cord-018225-dozmy3lb 244 2 patients patient NNS cord-018225-dozmy3lb 244 3 with with IN cord-018225-dozmy3lb 244 4 acute acute JJ cord-018225-dozmy3lb 244 5 liver liver NN cord-018225-dozmy3lb 244 6 failure failure NN cord-018225-dozmy3lb 244 7 secondary secondary JJ cord-018225-dozmy3lb 244 8 to to IN cord-018225-dozmy3lb 244 9 paracetamol paracetamol NNP cord-018225-dozmy3lb 244 10 were be VBD cord-018225-dozmy3lb 244 11 studied study VBN cord-018225-dozmy3lb 244 12 after after IN cord-018225-dozmy3lb 244 13 recovery recovery NN cord-018225-dozmy3lb 244 14 . . . cord-018225-dozmy3lb 245 1 In in IN cord-018225-dozmy3lb 245 2 this this DT cord-018225-dozmy3lb 245 3 group group NN cord-018225-dozmy3lb 245 4 , , , cord-018225-dozmy3lb 245 5 n n NN cord-018225-dozmy3lb 245 6 - - HYPH cord-018225-dozmy3lb 245 7 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 245 8 had have VBD cord-018225-dozmy3lb 245 9 no no DT cord-018225-dozmy3lb 245 10 effect effect NN cord-018225-dozmy3lb 245 11 on on IN cord-018225-dozmy3lb 245 12 any any DT cord-018225-dozmy3lb 245 13 hemodynamic hemodynamic JJ cord-018225-dozmy3lb 245 14 or or CC cord-018225-dozmy3lb 245 15 oxygen oxygen NN cord-018225-dozmy3lb 245 16 transport transport NN cord-018225-dozmy3lb 245 17 variable variable NN cord-018225-dozmy3lb 245 18 . . . cord-018225-dozmy3lb 246 1 However however RB cord-018225-dozmy3lb 246 2 , , , cord-018225-dozmy3lb 246 3 with with IN cord-018225-dozmy3lb 246 4 infusion infusion NN cord-018225-dozmy3lb 246 5 of of IN cord-018225-dozmy3lb 246 6 prostacyclin prostacyclin NNP cord-018225-dozmy3lb 246 7 , , , cord-018225-dozmy3lb 246 8 there there EX cord-018225-dozmy3lb 246 9 was be VBD cord-018225-dozmy3lb 246 10 an an DT cord-018225-dozmy3lb 246 11 increase increase NN cord-018225-dozmy3lb 246 12 in in IN cord-018225-dozmy3lb 246 13 cardiac cardiac JJ cord-018225-dozmy3lb 246 14 index index NN cord-018225-dozmy3lb 246 15 , , , cord-018225-dozmy3lb 246 16 decrease decrease VB cord-018225-dozmy3lb 246 17 in in IN cord-018225-dozmy3lb 246 18 systemic systemic JJ cord-018225-dozmy3lb 246 19 vascular vascular JJ cord-018225-dozmy3lb 246 20 resistance resistance NN cord-018225-dozmy3lb 246 21 , , , cord-018225-dozmy3lb 246 22 and and CC cord-018225-dozmy3lb 246 23 increased increase VBD cord-018225-dozmy3lb 246 24 oxygen oxygen NN cord-018225-dozmy3lb 246 25 delivery delivery NN cord-018225-dozmy3lb 246 26 without without IN cord-018225-dozmy3lb 246 27 an an DT cord-018225-dozmy3lb 246 28 increase increase NN cord-018225-dozmy3lb 246 29 in in IN cord-018225-dozmy3lb 246 30 consumption consumption NN cord-018225-dozmy3lb 246 31 . . . cord-018225-dozmy3lb 247 1 There there EX cord-018225-dozmy3lb 247 2 is be VBZ cord-018225-dozmy3lb 247 3 a a DT cord-018225-dozmy3lb 247 4 characteristic characteristic JJ cord-018225-dozmy3lb 247 5 high high JJ cord-018225-dozmy3lb 247 6 output output NN cord-018225-dozmy3lb 247 7 - - HYPH cord-018225-dozmy3lb 247 8 low low NN cord-018225-dozmy3lb 247 9 resistance resistance NN cord-018225-dozmy3lb 247 10 hemodynamic hemodynamic JJ cord-018225-dozmy3lb 247 11 state state NN cord-018225-dozmy3lb 247 12 in in IN cord-018225-dozmy3lb 247 13 fulminant fulminant JJ cord-018225-dozmy3lb 247 14 hepatic hepatic JJ cord-018225-dozmy3lb 247 15 failure failure NN cord-018225-dozmy3lb 247 16 that that WDT cord-018225-dozmy3lb 247 17 may may MD cord-018225-dozmy3lb 247 18 be be VB cord-018225-dozmy3lb 247 19 associated associate VBN cord-018225-dozmy3lb 247 20 with with IN cord-018225-dozmy3lb 247 21 covert covert JJ cord-018225-dozmy3lb 247 22 tissue tissue NN cord-018225-dozmy3lb 247 23 hypoxia hypoxia NN cord-018225-dozmy3lb 247 24 . . . cord-018225-dozmy3lb 248 1 Intravenous intravenous JJ cord-018225-dozmy3lb 248 2 infusion infusion NN cord-018225-dozmy3lb 248 3 of of IN cord-018225-dozmy3lb 248 4 n n NN cord-018225-dozmy3lb 248 5 - - HYPH cord-018225-dozmy3lb 248 6 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 248 7 was be VBD cord-018225-dozmy3lb 248 8 associated associate VBN cord-018225-dozmy3lb 248 9 with with IN cord-018225-dozmy3lb 248 10 an an DT cord-018225-dozmy3lb 248 11 increase increase NN cord-018225-dozmy3lb 248 12 in in IN cord-018225-dozmy3lb 248 13 oxygen oxygen NN cord-018225-dozmy3lb 248 14 delivery delivery NN cord-018225-dozmy3lb 248 15 and and CC cord-018225-dozmy3lb 248 16 consumption consumption NN cord-018225-dozmy3lb 248 17 , , , cord-018225-dozmy3lb 248 18 and and CC cord-018225-dozmy3lb 248 19 also also RB cord-018225-dozmy3lb 248 20 in in IN cord-018225-dozmy3lb 248 21 tissue tissue NN cord-018225-dozmy3lb 248 22 oxygen oxygen NN cord-018225-dozmy3lb 248 23 extraction extraction NN cord-018225-dozmy3lb 248 24 in in IN cord-018225-dozmy3lb 248 25 patients patient NNS cord-018225-dozmy3lb 248 26 with with IN cord-018225-dozmy3lb 248 27 fulminant fulminant JJ cord-018225-dozmy3lb 248 28 hepatic hepatic JJ cord-018225-dozmy3lb 248 29 failure failure NN cord-018225-dozmy3lb 248 30 . . . cord-018225-dozmy3lb 249 1 It -PRON- PRP cord-018225-dozmy3lb 249 2 is be VBZ cord-018225-dozmy3lb 249 3 postulated postulate VBN cord-018225-dozmy3lb 249 4 that that IN cord-018225-dozmy3lb 249 5 this this DT cord-018225-dozmy3lb 249 6 may may MD cord-018225-dozmy3lb 249 7 account account VB cord-018225-dozmy3lb 249 8 for for IN cord-018225-dozmy3lb 249 9 the the DT cord-018225-dozmy3lb 249 10 beneficial beneficial JJ cord-018225-dozmy3lb 249 11 effect effect NN cord-018225-dozmy3lb 249 12 of of IN cord-018225-dozmy3lb 249 13 n n NN cord-018225-dozmy3lb 249 14 - - NN cord-018225-dozmy3lb 249 15 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 249 16 on on IN cord-018225-dozmy3lb 249 17 survival survival NN cord-018225-dozmy3lb 249 18 in in IN cord-018225-dozmy3lb 249 19 patients patient NNS cord-018225-dozmy3lb 249 20 with with IN cord-018225-dozmy3lb 249 21 acute acute JJ cord-018225-dozmy3lb 249 22 liver liver NN cord-018225-dozmy3lb 249 23 failure failure NN cord-018225-dozmy3lb 249 24 caused cause VBN cord-018225-dozmy3lb 249 25 by by IN cord-018225-dozmy3lb 249 26 paracetamol paracetamol NNP cord-018225-dozmy3lb 249 27 , , , cord-018225-dozmy3lb 249 28 and and CC cord-018225-dozmy3lb 249 29 further further RB cord-018225-dozmy3lb 249 30 , , , cord-018225-dozmy3lb 249 31 may may MD cord-018225-dozmy3lb 249 32 be be VB cord-018225-dozmy3lb 249 33 of of IN cord-018225-dozmy3lb 249 34 benefit benefit NN cord-018225-dozmy3lb 249 35 in in IN cord-018225-dozmy3lb 249 36 patients patient NNS cord-018225-dozmy3lb 249 37 with with IN cord-018225-dozmy3lb 249 38 multiple multiple JJ cord-018225-dozmy3lb 249 39 organ organ NN cord-018225-dozmy3lb 249 40 failure failure NN cord-018225-dozmy3lb 249 41 from from IN cord-018225-dozmy3lb 249 42 other other JJ cord-018225-dozmy3lb 249 43 causes cause NNS cord-018225-dozmy3lb 249 44 , , , cord-018225-dozmy3lb 249 45 such such JJ cord-018225-dozmy3lb 249 46 as as IN cord-018225-dozmy3lb 249 47 sepsis sepsis NN cord-018225-dozmy3lb 249 48 . . . cord-018225-dozmy3lb 250 1 This this DT cord-018225-dozmy3lb 250 2 study study NN cord-018225-dozmy3lb 250 3 is be VBZ cord-018225-dozmy3lb 250 4 the the DT cord-018225-dozmy3lb 250 5 justification justification NN cord-018225-dozmy3lb 250 6 for for IN cord-018225-dozmy3lb 250 7 the the DT cord-018225-dozmy3lb 250 8 widespread widespread JJ cord-018225-dozmy3lb 250 9 use use NN cord-018225-dozmy3lb 250 10 of of IN cord-018225-dozmy3lb 250 11 n n NN cord-018225-dozmy3lb 250 12 - - HYPH cord-018225-dozmy3lb 250 13 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 250 14 in in IN cord-018225-dozmy3lb 250 15 patients patient NNS cord-018225-dozmy3lb 250 16 with with IN cord-018225-dozmy3lb 250 17 acute acute JJ cord-018225-dozmy3lb 250 18 liver liver NN cord-018225-dozmy3lb 250 19 failure failure NN cord-018225-dozmy3lb 250 20 , , , cord-018225-dozmy3lb 250 21 and and CC cord-018225-dozmy3lb 250 22 it -PRON- PRP cord-018225-dozmy3lb 250 23 has have VBZ cord-018225-dozmy3lb 250 24 also also RB cord-018225-dozmy3lb 250 25 provoked provoke VBN cord-018225-dozmy3lb 250 26 investigation investigation NN cord-018225-dozmy3lb 250 27 of of IN cord-018225-dozmy3lb 250 28 possible possible JJ cord-018225-dozmy3lb 250 29 clinical clinical JJ cord-018225-dozmy3lb 250 30 benefits benefit NNS cord-018225-dozmy3lb 250 31 in in IN cord-018225-dozmy3lb 250 32 other other JJ cord-018225-dozmy3lb 250 33 conditions condition NNS cord-018225-dozmy3lb 250 34 , , , cord-018225-dozmy3lb 250 35 such such JJ cord-018225-dozmy3lb 250 36 as as IN cord-018225-dozmy3lb 250 37 septic septic JJ cord-018225-dozmy3lb 250 38 shock shock NN cord-018225-dozmy3lb 250 39 . . . cord-018225-dozmy3lb 251 1 This this DT cord-018225-dozmy3lb 251 2 is be VBZ cord-018225-dozmy3lb 251 3 a a DT cord-018225-dozmy3lb 251 4 comprehensive comprehensive JJ cord-018225-dozmy3lb 251 5 clinical clinical JJ cord-018225-dozmy3lb 251 6 study study NN cord-018225-dozmy3lb 251 7 of of IN cord-018225-dozmy3lb 251 8 a a DT cord-018225-dozmy3lb 251 9 relatively relatively RB cord-018225-dozmy3lb 251 10 homogeneous homogeneous JJ cord-018225-dozmy3lb 251 11 group group NN cord-018225-dozmy3lb 251 12 of of IN cord-018225-dozmy3lb 251 13 patients patient NNS cord-018225-dozmy3lb 251 14 . . . cord-018225-dozmy3lb 252 1 Because because IN cord-018225-dozmy3lb 252 2 the the DT cord-018225-dozmy3lb 252 3 Fick Fick NNP cord-018225-dozmy3lb 252 4 method method NN cord-018225-dozmy3lb 252 5 was be VBD cord-018225-dozmy3lb 252 6 used use VBN cord-018225-dozmy3lb 252 7 to to TO cord-018225-dozmy3lb 252 8 calculate calculate VB cord-018225-dozmy3lb 252 9 oxygen oxygen NN cord-018225-dozmy3lb 252 10 consumption consumption NN cord-018225-dozmy3lb 252 11 from from IN cord-018225-dozmy3lb 252 12 the the DT cord-018225-dozmy3lb 252 13 cardiac cardiac JJ cord-018225-dozmy3lb 252 14 output output NN cord-018225-dozmy3lb 252 15 and and CC cord-018225-dozmy3lb 252 16 the the DT cord-018225-dozmy3lb 252 17 arteriovenous arteriovenous JJ cord-018225-dozmy3lb 252 18 oxygen oxygen NN cord-018225-dozmy3lb 252 19 content content NN cord-018225-dozmy3lb 252 20 difference difference NN cord-018225-dozmy3lb 252 21 , , , cord-018225-dozmy3lb 252 22 it -PRON- PRP cord-018225-dozmy3lb 252 23 is be VBZ cord-018225-dozmy3lb 252 24 possible possible JJ cord-018225-dozmy3lb 252 25 that that IN cord-018225-dozmy3lb 252 26 an an DT cord-018225-dozmy3lb 252 27 artifactual artifactual JJ cord-018225-dozmy3lb 252 28 relationship relationship NN cord-018225-dozmy3lb 252 29 between between IN cord-018225-dozmy3lb 252 30 oxygen oxygen NN cord-018225-dozmy3lb 252 31 delivery delivery NN cord-018225-dozmy3lb 252 32 and and CC cord-018225-dozmy3lb 252 33 consumption consumption NN cord-018225-dozmy3lb 252 34 was be VBD cord-018225-dozmy3lb 252 35 shown show VBN cord-018225-dozmy3lb 252 36 because because IN cord-018225-dozmy3lb 252 37 of of IN cord-018225-dozmy3lb 252 38 mathematical mathematical JJ cord-018225-dozmy3lb 252 39 coupling coupling NN cord-018225-dozmy3lb 252 40 . . . cord-018225-dozmy3lb 253 1 It -PRON- PRP cord-018225-dozmy3lb 253 2 is be VBZ cord-018225-dozmy3lb 253 3 now now RB cord-018225-dozmy3lb 253 4 generally generally RB cord-018225-dozmy3lb 253 5 accepted accept VBN cord-018225-dozmy3lb 253 6 that that IN cord-018225-dozmy3lb 253 7 oxygen oxygen NN cord-018225-dozmy3lb 253 8 delivery delivery NN cord-018225-dozmy3lb 253 9 and and CC cord-018225-dozmy3lb 253 10 consumption consumption NN cord-018225-dozmy3lb 253 11 should should MD cord-018225-dozmy3lb 253 12 be be VB cord-018225-dozmy3lb 253 13 determined determine VBN cord-018225-dozmy3lb 253 14 independently independently RB cord-018225-dozmy3lb 253 15 . . . cord-018225-dozmy3lb 254 1 Although although IN cord-018225-dozmy3lb 254 2 undoubtedly undoubtedly RB cord-018225-dozmy3lb 254 3 a a DT cord-018225-dozmy3lb 254 4 classic classic JJ cord-018225-dozmy3lb 254 5 study study NN cord-018225-dozmy3lb 254 6 , , , cord-018225-dozmy3lb 254 7 the the DT cord-018225-dozmy3lb 254 8 findings finding NNS cord-018225-dozmy3lb 254 9 presented present VBN cord-018225-dozmy3lb 254 10 in in IN cord-018225-dozmy3lb 254 11 this this DT cord-018225-dozmy3lb 254 12 paper paper NN cord-018225-dozmy3lb 254 13 have have VBP cord-018225-dozmy3lb 254 14 not not RB cord-018225-dozmy3lb 254 15 been be VBN cord-018225-dozmy3lb 254 16 confirmed confirm VBN cord-018225-dozmy3lb 254 17 in in IN cord-018225-dozmy3lb 254 18 a a DT cord-018225-dozmy3lb 254 19 similar similar JJ cord-018225-dozmy3lb 254 20 more more RBR cord-018225-dozmy3lb 254 21 recent recent JJ cord-018225-dozmy3lb 254 22 study study NN cord-018225-dozmy3lb 254 23 ( ( -LRB- cord-018225-dozmy3lb 254 24 see see VB cord-018225-dozmy3lb 254 25 Related related JJ cord-018225-dozmy3lb 254 26 reference reference NN cord-018225-dozmy3lb 254 27 no no NN cord-018225-dozmy3lb 254 28 . . NN cord-018225-dozmy3lb 254 29 1 1 CD cord-018225-dozmy3lb 254 30 ) ) -RRB- cord-018225-dozmy3lb 254 31 . . . cord-018225-dozmy3lb 255 1 In in IN cord-018225-dozmy3lb 255 2 the the DT cord-018225-dozmy3lb 255 3 latter latter JJ cord-018225-dozmy3lb 255 4 study study NN cord-018225-dozmy3lb 255 5 , , , cord-018225-dozmy3lb 255 6 oxygen oxygen NN cord-018225-dozmy3lb 255 7 consumption consumption NN cord-018225-dozmy3lb 255 8 was be VBD cord-018225-dozmy3lb 255 9 measured measure VBN cord-018225-dozmy3lb 255 10 independently independently RB cord-018225-dozmy3lb 255 11 of of IN cord-018225-dozmy3lb 255 12 oxygen oxygen NN cord-018225-dozmy3lb 255 13 delivery delivery NN cord-018225-dozmy3lb 255 14 , , , cord-018225-dozmy3lb 255 15 using use VBG cord-018225-dozmy3lb 255 16 a a DT cord-018225-dozmy3lb 255 17 method method NN cord-018225-dozmy3lb 255 18 based base VBN cord-018225-dozmy3lb 255 19 on on IN cord-018225-dozmy3lb 255 20 respiratory respiratory JJ cord-018225-dozmy3lb 255 21 gas gas NN cord-018225-dozmy3lb 255 22 analysis analysis NN cord-018225-dozmy3lb 255 23 , , , cord-018225-dozmy3lb 255 24 and and CC cord-018225-dozmy3lb 255 25 patients patient NNS cord-018225-dozmy3lb 255 26 were be VBD cord-018225-dozmy3lb 255 27 studied study VBN cord-018225-dozmy3lb 255 28 over over IN cord-018225-dozmy3lb 255 29 a a DT cord-018225-dozmy3lb 255 30 longer long JJR cord-018225-dozmy3lb 255 31 period period NN cord-018225-dozmy3lb 255 32 . . . cord-018225-dozmy3lb 256 1 Nevertheless nevertheless RB cord-018225-dozmy3lb 256 2 , , , cord-018225-dozmy3lb 256 3 the the DT cord-018225-dozmy3lb 256 4 paper paper NN cord-018225-dozmy3lb 256 5 under under IN cord-018225-dozmy3lb 256 6 review review NN cord-018225-dozmy3lb 256 7 has have VBZ cord-018225-dozmy3lb 256 8 been be VBN cord-018225-dozmy3lb 256 9 responsible responsible JJ cord-018225-dozmy3lb 256 10 in in IN cord-018225-dozmy3lb 256 11 part part NN cord-018225-dozmy3lb 256 12 for for IN cord-018225-dozmy3lb 256 13 a a DT cord-018225-dozmy3lb 256 14 resurgence resurgence NN cord-018225-dozmy3lb 256 15 of of IN cord-018225-dozmy3lb 256 16 interest interest NN cord-018225-dozmy3lb 256 17 in in IN cord-018225-dozmy3lb 256 18 n n NN cord-018225-dozmy3lb 256 19 - - HYPH cord-018225-dozmy3lb 256 20 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 256 21 as as IN cord-018225-dozmy3lb 256 22 a a DT cord-018225-dozmy3lb 256 23 therapeutic therapeutic JJ cord-018225-dozmy3lb 256 24 agent agent NN cord-018225-dozmy3lb 256 25 , , , cord-018225-dozmy3lb 256 26 not not RB cord-018225-dozmy3lb 256 27 only only RB cord-018225-dozmy3lb 256 28 in in IN cord-018225-dozmy3lb 256 29 patients patient NNS cord-018225-dozmy3lb 256 30 with with IN cord-018225-dozmy3lb 256 31 acute acute JJ cord-018225-dozmy3lb 256 32 liver liver NN cord-018225-dozmy3lb 256 33 failure failure NN cord-018225-dozmy3lb 256 34 , , , cord-018225-dozmy3lb 256 35 but but CC cord-018225-dozmy3lb 256 36 also also RB cord-018225-dozmy3lb 256 37 in in IN cord-018225-dozmy3lb 256 38 other other JJ cord-018225-dozmy3lb 256 39 groups group NNS cord-018225-dozmy3lb 256 40 of of IN cord-018225-dozmy3lb 256 41 critically critically RB cord-018225-dozmy3lb 256 42 ill ill JJ cord-018225-dozmy3lb 256 43 patients patient NNS cord-018225-dozmy3lb 256 44 , , , cord-018225-dozmy3lb 256 45 such such JJ cord-018225-dozmy3lb 256 46 as as IN cord-018225-dozmy3lb 256 47 those those DT cord-018225-dozmy3lb 256 48 with with IN cord-018225-dozmy3lb 256 49 sepsis sepsis NN cord-018225-dozmy3lb 256 50 , , , cord-018225-dozmy3lb 256 51 acute acute JJ cord-018225-dozmy3lb 256 52 lung lung NN cord-018225-dozmy3lb 256 53 injury injury NN cord-018225-dozmy3lb 256 54 , , , cord-018225-dozmy3lb 256 55 and and CC cord-018225-dozmy3lb 256 56 multiple multiple JJ cord-018225-dozmy3lb 256 57 organ organ NN cord-018225-dozmy3lb 256 58 failure failure NN cord-018225-dozmy3lb 256 59 . . . cord-018225-dozmy3lb 257 1 As as IN cord-018225-dozmy3lb 257 2 with with IN cord-018225-dozmy3lb 257 3 acute acute JJ cord-018225-dozmy3lb 257 4 hepatic hepatic JJ cord-018225-dozmy3lb 257 5 failure failure NN cord-018225-dozmy3lb 257 6 , , , cord-018225-dozmy3lb 257 7 published publish VBN cord-018225-dozmy3lb 257 8 studies study NNS cord-018225-dozmy3lb 257 9 of of IN cord-018225-dozmy3lb 257 10 other other JJ cord-018225-dozmy3lb 257 11 groups group NNS cord-018225-dozmy3lb 257 12 of of IN cord-018225-dozmy3lb 257 13 critically critically RB cord-018225-dozmy3lb 257 14 ill ill JJ cord-018225-dozmy3lb 257 15 patients patient NNS cord-018225-dozmy3lb 257 16 have have VBP cord-018225-dozmy3lb 257 17 shown show VBN cord-018225-dozmy3lb 257 18 inconsistent inconsistent JJ cord-018225-dozmy3lb 257 19 findings finding NNS cord-018225-dozmy3lb 257 20 , , , cord-018225-dozmy3lb 257 21 and and CC cord-018225-dozmy3lb 257 22 the the DT cord-018225-dozmy3lb 257 23 role role NN cord-018225-dozmy3lb 257 24 of of IN cord-018225-dozmy3lb 257 25 n n NN cord-018225-dozmy3lb 257 26 - - HYPH cord-018225-dozmy3lb 257 27 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 257 28 in in IN cord-018225-dozmy3lb 257 29 critically critically RB cord-018225-dozmy3lb 257 30 ill ill JJ cord-018225-dozmy3lb 257 31 patients patient NNS cord-018225-dozmy3lb 257 32 remains remain VBZ cord-018225-dozmy3lb 257 33 unclear unclear JJ cord-018225-dozmy3lb 257 34 . . . cord-018225-dozmy3lb 258 1 This this DT cord-018225-dozmy3lb 258 2 paper paper NN cord-018225-dozmy3lb 258 3 marks mark VBZ cord-018225-dozmy3lb 258 4 the the DT cord-018225-dozmy3lb 258 5 beginning beginning NN cord-018225-dozmy3lb 258 6 of of IN cord-018225-dozmy3lb 258 7 a a DT cord-018225-dozmy3lb 258 8 long long JJ cord-018225-dozmy3lb 258 9 and and CC cord-018225-dozmy3lb 258 10 still still RB cord-018225-dozmy3lb 258 11 - - HYPH cord-018225-dozmy3lb 258 12 continuing continue VBG cord-018225-dozmy3lb 258 13 struggle struggle NN cord-018225-dozmy3lb 258 14 to to TO cord-018225-dozmy3lb 258 15 find find VB cord-018225-dozmy3lb 258 16 a a DT cord-018225-dozmy3lb 258 17 clinically clinically RB cord-018225-dozmy3lb 258 18 relevant relevant JJ cord-018225-dozmy3lb 258 19 artificial artificial JJ cord-018225-dozmy3lb 258 20 liver liver NN cord-018225-dozmy3lb 258 21 device device NN cord-018225-dozmy3lb 258 22 that that WDT cord-018225-dozmy3lb 258 23 can can MD cord-018225-dozmy3lb 258 24 be be VB cord-018225-dozmy3lb 258 25 used use VBN cord-018225-dozmy3lb 258 26 as as IN cord-018225-dozmy3lb 258 27 a a DT cord-018225-dozmy3lb 258 28 bridge bridge NN cord-018225-dozmy3lb 258 29 to to IN cord-018225-dozmy3lb 258 30 regeneration regeneration NN cord-018225-dozmy3lb 258 31 or or CC cord-018225-dozmy3lb 258 32 transplantation transplantation NN cord-018225-dozmy3lb 258 33 in in IN cord-018225-dozmy3lb 258 34 patients patient NNS cord-018225-dozmy3lb 258 35 with with IN cord-018225-dozmy3lb 258 36 acute acute JJ cord-018225-dozmy3lb 258 37 liver liver NN cord-018225-dozmy3lb 258 38 failure failure NN cord-018225-dozmy3lb 258 39 . . . cord-018225-dozmy3lb 259 1 This this DT cord-018225-dozmy3lb 259 2 is be VBZ cord-018225-dozmy3lb 259 3 a a DT cord-018225-dozmy3lb 259 4 report report NN cord-018225-dozmy3lb 259 5 of of IN cord-018225-dozmy3lb 259 6 original original JJ cord-018225-dozmy3lb 259 7 and and CC cord-018225-dozmy3lb 259 8 far far RB cord-018225-dozmy3lb 259 9 - - HYPH cord-018225-dozmy3lb 259 10 sighted sight VBN cord-018225-dozmy3lb 259 11 ideas idea NNS cord-018225-dozmy3lb 259 12 that that WDT cord-018225-dozmy3lb 259 13 must must MD cord-018225-dozmy3lb 259 14 have have VB cord-018225-dozmy3lb 259 15 stretched stretch VBN cord-018225-dozmy3lb 259 16 the the DT cord-018225-dozmy3lb 259 17 boundaries boundary NNS cord-018225-dozmy3lb 259 18 of of IN cord-018225-dozmy3lb 259 19 knowledge knowledge NN cord-018225-dozmy3lb 259 20 and and CC cord-018225-dozmy3lb 259 21 technology technology NN cord-018225-dozmy3lb 259 22 in in IN cord-018225-dozmy3lb 259 23 the the DT cord-018225-dozmy3lb 259 24 late late JJ cord-018225-dozmy3lb 259 25 1960s 1960 NNS cord-018225-dozmy3lb 259 26 . . . cord-018225-dozmy3lb 260 1 This this DT cord-018225-dozmy3lb 260 2 is be VBZ cord-018225-dozmy3lb 260 3 a a DT cord-018225-dozmy3lb 260 4 case case NN cord-018225-dozmy3lb 260 5 report report NN cord-018225-dozmy3lb 260 6 only only RB cord-018225-dozmy3lb 260 7 . . . cord-018225-dozmy3lb 261 1 It -PRON- PRP cord-018225-dozmy3lb 261 2 is be VBZ cord-018225-dozmy3lb 261 3 possible possible JJ cord-018225-dozmy3lb 261 4 that that IN cord-018225-dozmy3lb 261 5 the the DT cord-018225-dozmy3lb 261 6 improvement improvement NN cord-018225-dozmy3lb 261 7 after after IN cord-018225-dozmy3lb 261 8 cross cross NN cord-018225-dozmy3lb 261 9 - - NN cord-018225-dozmy3lb 261 10 circulation circulation NN cord-018225-dozmy3lb 261 11 may may MD cord-018225-dozmy3lb 261 12 have have VB cord-018225-dozmy3lb 261 13 been be VBN cord-018225-dozmy3lb 261 14 incidental incidental JJ cord-018225-dozmy3lb 261 15 , , , cord-018225-dozmy3lb 261 16 and and CC cord-018225-dozmy3lb 261 17 the the DT cord-018225-dozmy3lb 261 18 patient patient NN cord-018225-dozmy3lb 261 19 may may MD cord-018225-dozmy3lb 261 20 have have VB cord-018225-dozmy3lb 261 21 recovered recover VBN cord-018225-dozmy3lb 261 22 spontaneously spontaneously RB cord-018225-dozmy3lb 261 23 without without IN cord-018225-dozmy3lb 261 24 it -PRON- PRP cord-018225-dozmy3lb 261 25 . . . cord-018225-dozmy3lb 262 1 The the DT cord-018225-dozmy3lb 262 2 precise precise JJ cord-018225-dozmy3lb 262 3 technique technique NN cord-018225-dozmy3lb 262 4 used use VBN cord-018225-dozmy3lb 262 5 in in IN cord-018225-dozmy3lb 262 6 this this DT cord-018225-dozmy3lb 262 7 report report NN cord-018225-dozmy3lb 262 8 is be VBZ cord-018225-dozmy3lb 262 9 most most RBS cord-018225-dozmy3lb 262 10 unlikely unlikely JJ cord-018225-dozmy3lb 262 11 to to TO cord-018225-dozmy3lb 262 12 be be VB cord-018225-dozmy3lb 262 13 used use VBN cord-018225-dozmy3lb 262 14 again again RB cord-018225-dozmy3lb 262 15 because because IN cord-018225-dozmy3lb 262 16 of of IN cord-018225-dozmy3lb 262 17 concerns concern NNS cord-018225-dozmy3lb 262 18 about about IN cord-018225-dozmy3lb 262 19 transmission transmission NN cord-018225-dozmy3lb 262 20 of of IN cord-018225-dozmy3lb 262 21 infection infection NN cord-018225-dozmy3lb 262 22 , , , cord-018225-dozmy3lb 262 23 and and CC cord-018225-dozmy3lb 262 24 immunological immunological JJ cord-018225-dozmy3lb 262 25 considerations consideration NNS cord-018225-dozmy3lb 262 26 . . . cord-018225-dozmy3lb 263 1 However however RB cord-018225-dozmy3lb 263 2 , , , cord-018225-dozmy3lb 263 3 more more JJR cord-018225-dozmy3lb 263 4 than than IN cord-018225-dozmy3lb 263 5 30 30 CD cord-018225-dozmy3lb 263 6 years year NNS cord-018225-dozmy3lb 263 7 later later RB cord-018225-dozmy3lb 263 8 , , , cord-018225-dozmy3lb 263 9 there there EX cord-018225-dozmy3lb 263 10 remains remain VBZ cord-018225-dozmy3lb 263 11 a a DT cord-018225-dozmy3lb 263 12 need need NN cord-018225-dozmy3lb 263 13 to to TO cord-018225-dozmy3lb 263 14 develop develop VB cord-018225-dozmy3lb 263 15 a a DT cord-018225-dozmy3lb 263 16 safe safe JJ cord-018225-dozmy3lb 263 17 and and CC cord-018225-dozmy3lb 263 18 effective effective JJ cord-018225-dozmy3lb 263 19 artificial artificial JJ cord-018225-dozmy3lb 263 20 liver liver NN cord-018225-dozmy3lb 263 21 for for IN cord-018225-dozmy3lb 263 22 use use NN cord-018225-dozmy3lb 263 23 in in IN cord-018225-dozmy3lb 263 24 patients patient NNS cord-018225-dozmy3lb 263 25 with with IN cord-018225-dozmy3lb 263 26 acute acute JJ cord-018225-dozmy3lb 263 27 liver liver NN cord-018225-dozmy3lb 263 28 failure failure NN cord-018225-dozmy3lb 263 29 . . . cord-018225-dozmy3lb 264 1 Abstract abstract JJ cord-018225-dozmy3lb 264 2 BACKGROUND background NN cord-018225-dozmy3lb 264 3 : : : cord-018225-dozmy3lb 265 1 In in IN cord-018225-dozmy3lb 265 2 patients patient NNS cord-018225-dozmy3lb 265 3 with with IN cord-018225-dozmy3lb 265 4 cirrhosis cirrhosis NN cord-018225-dozmy3lb 265 5 and and CC cord-018225-dozmy3lb 265 6 spontaneous spontaneous JJ cord-018225-dozmy3lb 265 7 bacterial bacterial JJ cord-018225-dozmy3lb 265 8 peritonitis peritonitis NN cord-018225-dozmy3lb 265 9 , , , cord-018225-dozmy3lb 265 10 renal renal JJ cord-018225-dozmy3lb 265 11 function function NN cord-018225-dozmy3lb 265 12 frequently frequently RB cord-018225-dozmy3lb 265 13 becomes become VBZ cord-018225-dozmy3lb 265 14 impaired impaired JJ cord-018225-dozmy3lb 265 15 . . . cord-018225-dozmy3lb 266 1 This this DT cord-018225-dozmy3lb 266 2 impairment impairment NN cord-018225-dozmy3lb 266 3 is be VBZ cord-018225-dozmy3lb 266 4 probably probably RB cord-018225-dozmy3lb 266 5 related relate VBN cord-018225-dozmy3lb 266 6 to to IN cord-018225-dozmy3lb 266 7 a a DT cord-018225-dozmy3lb 266 8 reduction reduction NN cord-018225-dozmy3lb 266 9 in in IN cord-018225-dozmy3lb 266 10 effective effective JJ cord-018225-dozmy3lb 266 11 arterial arterial JJ cord-018225-dozmy3lb 266 12 blood blood NN cord-018225-dozmy3lb 266 13 volume volume NN cord-018225-dozmy3lb 266 14 , , , cord-018225-dozmy3lb 266 15 and and CC cord-018225-dozmy3lb 266 16 is be VBZ cord-018225-dozmy3lb 266 17 associated associate VBN cord-018225-dozmy3lb 266 18 with with IN cord-018225-dozmy3lb 266 19 a a DT cord-018225-dozmy3lb 266 20 high high JJ cord-018225-dozmy3lb 266 21 mortality mortality NN cord-018225-dozmy3lb 266 22 rate rate NN cord-018225-dozmy3lb 266 23 . . . cord-018225-dozmy3lb 267 1 We -PRON- PRP cord-018225-dozmy3lb 267 2 conducted conduct VBD cord-018225-dozmy3lb 267 3 a a DT cord-018225-dozmy3lb 267 4 study study NN cord-018225-dozmy3lb 267 5 to to TO cord-018225-dozmy3lb 267 6 determine determine VB cord-018225-dozmy3lb 267 7 whether whether IN cord-018225-dozmy3lb 267 8 plasma plasma NN cord-018225-dozmy3lb 267 9 volume volume NN cord-018225-dozmy3lb 267 10 expansion expansion NN cord-018225-dozmy3lb 267 11 with with IN cord-018225-dozmy3lb 267 12 intravenous intravenous JJ cord-018225-dozmy3lb 267 13 albumin albumin NN cord-018225-dozmy3lb 267 14 prevents prevent VBZ cord-018225-dozmy3lb 267 15 renal renal JJ cord-018225-dozmy3lb 267 16 impairment impairment NN cord-018225-dozmy3lb 267 17 and and CC cord-018225-dozmy3lb 267 18 reduces reduce VBZ cord-018225-dozmy3lb 267 19 mortality mortality NN cord-018225-dozmy3lb 267 20 in in IN cord-018225-dozmy3lb 267 21 these these DT cord-018225-dozmy3lb 267 22 patients patient NNS cord-018225-dozmy3lb 267 23 . . . cord-018225-dozmy3lb 268 1 METHODS methods NN cord-018225-dozmy3lb 268 2 : : : cord-018225-dozmy3lb 269 1 We -PRON- PRP cord-018225-dozmy3lb 269 2 randomly randomly RB cord-018225-dozmy3lb 269 3 assigned assign VBD cord-018225-dozmy3lb 269 4 126 126 CD cord-018225-dozmy3lb 269 5 patients patient NNS cord-018225-dozmy3lb 269 6 with with IN cord-018225-dozmy3lb 269 7 cirrhosis cirrhosis NN cord-018225-dozmy3lb 269 8 and and CC cord-018225-dozmy3lb 269 9 spontaneous spontaneous JJ cord-018225-dozmy3lb 269 10 bacterial bacterial JJ cord-018225-dozmy3lb 269 11 peritonitis peritonitis NN cord-018225-dozmy3lb 269 12 to to IN cord-018225-dozmy3lb 269 13 treatment treatment NN cord-018225-dozmy3lb 269 14 with with IN cord-018225-dozmy3lb 269 15 intravenous intravenous JJ cord-018225-dozmy3lb 269 16 cefotaxime cefotaxime NN cord-018225-dozmy3lb 269 17 ( ( -LRB- cord-018225-dozmy3lb 269 18 63 63 CD cord-018225-dozmy3lb 269 19 patients patient NNS cord-018225-dozmy3lb 269 20 ) ) -RRB- cord-018225-dozmy3lb 269 21 , , , cord-018225-dozmy3lb 269 22 or or CC cord-018225-dozmy3lb 269 23 cefotaxime cefotaxime NN cord-018225-dozmy3lb 269 24 and and CC cord-018225-dozmy3lb 269 25 intravenous intravenous JJ cord-018225-dozmy3lb 269 26 albumin albumin NN cord-018225-dozmy3lb 269 27 ( ( -LRB- cord-018225-dozmy3lb 269 28 63 63 CD cord-018225-dozmy3lb 269 29 patients patient NNS cord-018225-dozmy3lb 269 30 ) ) -RRB- cord-018225-dozmy3lb 269 31 . . . cord-018225-dozmy3lb 270 1 Cefotaxime Cefotaxime NNP cord-018225-dozmy3lb 270 2 was be VBD cord-018225-dozmy3lb 270 3 given give VBN cord-018225-dozmy3lb 270 4 daily daily RB cord-018225-dozmy3lb 270 5 in in IN cord-018225-dozmy3lb 270 6 dosages dosage NNS cord-018225-dozmy3lb 270 7 that that WDT cord-018225-dozmy3lb 270 8 varied vary VBD cord-018225-dozmy3lb 270 9 according accord VBG cord-018225-dozmy3lb 270 10 to to IN cord-018225-dozmy3lb 270 11 the the DT cord-018225-dozmy3lb 270 12 serum serum NN cord-018225-dozmy3lb 270 13 creatinine creatinine NN cord-018225-dozmy3lb 270 14 level level NN cord-018225-dozmy3lb 270 15 , , , cord-018225-dozmy3lb 270 16 and and CC cord-018225-dozmy3lb 270 17 albumin albumin NN cord-018225-dozmy3lb 270 18 was be VBD cord-018225-dozmy3lb 270 19 given give VBN cord-018225-dozmy3lb 270 20 at at IN cord-018225-dozmy3lb 270 21 a a DT cord-018225-dozmy3lb 270 22 dose dose NN cord-018225-dozmy3lb 270 23 of of IN cord-018225-dozmy3lb 270 24 1.5 1.5 CD cord-018225-dozmy3lb 270 25 kg kg NNS cord-018225-dozmy3lb 270 26 of of IN cord-018225-dozmy3lb 270 27 body body NN cord-018225-dozmy3lb 270 28 weight weight NN cord-018225-dozmy3lb 270 29 at at IN cord-018225-dozmy3lb 270 30 the the DT cord-018225-dozmy3lb 270 31 time time NN cord-018225-dozmy3lb 270 32 of of IN cord-018225-dozmy3lb 270 33 diagnosis diagnosis NN cord-018225-dozmy3lb 270 34 , , , cord-018225-dozmy3lb 270 35 followed follow VBN cord-018225-dozmy3lb 270 36 by by IN cord-018225-dozmy3lb 270 37 1 1 CD cord-018225-dozmy3lb 270 38 kg kg NNS cord-018225-dozmy3lb 270 39 on on IN cord-018225-dozmy3lb 270 40 day day NN cord-018225-dozmy3lb 270 41 3 3 CD cord-018225-dozmy3lb 270 42 . . . cord-018225-dozmy3lb 271 1 Renal renal JJ cord-018225-dozmy3lb 271 2 impairment impairment NN cord-018225-dozmy3lb 271 3 was be VBD cord-018225-dozmy3lb 271 4 defined define VBN cord-018225-dozmy3lb 271 5 as as IN cord-018225-dozmy3lb 271 6 nonreversible nonreversible JJ cord-018225-dozmy3lb 271 7 deterioration deterioration NN cord-018225-dozmy3lb 271 8 of of IN cord-018225-dozmy3lb 271 9 renal renal JJ cord-018225-dozmy3lb 271 10 function function NN cord-018225-dozmy3lb 271 11 during during IN cord-018225-dozmy3lb 271 12 hospitalization hospitalization NN cord-018225-dozmy3lb 271 13 . . . cord-018225-dozmy3lb 272 1 RESULTS result NNS cord-018225-dozmy3lb 272 2 : : : cord-018225-dozmy3lb 273 1 The the DT cord-018225-dozmy3lb 273 2 infection infection NN cord-018225-dozmy3lb 273 3 resolved resolve VBD cord-018225-dozmy3lb 273 4 in in IN cord-018225-dozmy3lb 273 5 59 59 CD cord-018225-dozmy3lb 273 6 patients patient NNS cord-018225-dozmy3lb 273 7 in in IN cord-018225-dozmy3lb 273 8 the the DT cord-018225-dozmy3lb 273 9 cefotaxime cefotaxime NNP cord-018225-dozmy3lb 273 10 group group NN cord-018225-dozmy3lb 273 11 ( ( -LRB- cord-018225-dozmy3lb 273 12 94 94 CD cord-018225-dozmy3lb 273 13 % % NN cord-018225-dozmy3lb 273 14 ) ) -RRB- cord-018225-dozmy3lb 273 15 and and CC cord-018225-dozmy3lb 273 16 62 62 CD cord-018225-dozmy3lb 273 17 in in IN cord-018225-dozmy3lb 273 18 the the DT cord-018225-dozmy3lb 273 19 cefotaxime cefotaxime NN cord-018225-dozmy3lb 273 20 - - HYPH cord-018225-dozmy3lb 273 21 plus plus CC cord-018225-dozmy3lb 273 22 - - HYPH cord-018225-dozmy3lb 273 23 albumin albumin NN cord-018225-dozmy3lb 273 24 group group NN cord-018225-dozmy3lb 273 25 ( ( -LRB- cord-018225-dozmy3lb 273 26 98 98 CD cord-018225-dozmy3lb 273 27 % % NN cord-018225-dozmy3lb 273 28 ) ) -RRB- cord-018225-dozmy3lb 274 1 ( ( -LRB- cord-018225-dozmy3lb 274 2 p p NN cord-018225-dozmy3lb 274 3 = = SYM cord-018225-dozmy3lb 274 4 0.36 0.36 CD cord-018225-dozmy3lb 274 5 ) ) -RRB- cord-018225-dozmy3lb 274 6 . . . cord-018225-dozmy3lb 275 1 Renal renal JJ cord-018225-dozmy3lb 275 2 impairment impairment NN cord-018225-dozmy3lb 275 3 developed develop VBN cord-018225-dozmy3lb 275 4 in in IN cord-018225-dozmy3lb 275 5 21 21 CD cord-018225-dozmy3lb 275 6 patients patient NNS cord-018225-dozmy3lb 275 7 in in IN cord-018225-dozmy3lb 275 8 the the DT cord-018225-dozmy3lb 275 9 cefotaxime cefotaxime NNP cord-018225-dozmy3lb 275 10 group group NN cord-018225-dozmy3lb 275 11 ( ( -LRB- cord-018225-dozmy3lb 275 12 33 33 CD cord-018225-dozmy3lb 275 13 % % NN cord-018225-dozmy3lb 275 14 ) ) -RRB- cord-018225-dozmy3lb 275 15 , , , cord-018225-dozmy3lb 275 16 and and CC cord-018225-dozmy3lb 275 17 6 6 CD cord-018225-dozmy3lb 275 18 in in IN cord-018225-dozmy3lb 275 19 the the DT cord-018225-dozmy3lb 275 20 cefotaxime cefotaxime NN cord-018225-dozmy3lb 275 21 - - HYPH cord-018225-dozmy3lb 275 22 plus plus CC cord-018225-dozmy3lb 275 23 - - HYPH cord-018225-dozmy3lb 275 24 albumin albumin NN cord-018225-dozmy3lb 275 25 group group NN cord-018225-dozmy3lb 275 26 ( ( -LRB- cord-018225-dozmy3lb 275 27 10 10 CD cord-018225-dozmy3lb 275 28 % % NN cord-018225-dozmy3lb 275 29 ) ) -RRB- cord-018225-dozmy3lb 276 1 ( ( -LRB- cord-018225-dozmy3lb 276 2 p p NN cord-018225-dozmy3lb 276 3 = = SYM cord-018225-dozmy3lb 276 4 0.002 0.002 CD cord-018225-dozmy3lb 276 5 ) ) -RRB- cord-018225-dozmy3lb 276 6 . . . cord-018225-dozmy3lb 277 1 Eighteen eighteen CD cord-018225-dozmy3lb 277 2 patients patient NNS cord-018225-dozmy3lb 277 3 ( ( -LRB- cord-018225-dozmy3lb 277 4 29 29 CD cord-018225-dozmy3lb 277 5 % % NN cord-018225-dozmy3lb 277 6 ) ) -RRB- cord-018225-dozmy3lb 277 7 in in IN cord-018225-dozmy3lb 277 8 the the DT cord-018225-dozmy3lb 277 9 cefotaxime cefotaxime NNP cord-018225-dozmy3lb 277 10 group group NN cord-018225-dozmy3lb 277 11 died die VBD cord-018225-dozmy3lb 277 12 in in IN cord-018225-dozmy3lb 277 13 the the DT cord-018225-dozmy3lb 277 14 hospital hospital NN cord-018225-dozmy3lb 277 15 , , , cord-018225-dozmy3lb 277 16 as as IN cord-018225-dozmy3lb 277 17 compared compare VBN cord-018225-dozmy3lb 277 18 with with IN cord-018225-dozmy3lb 277 19 6 6 CD cord-018225-dozmy3lb 277 20 ( ( -LRB- cord-018225-dozmy3lb 277 21 10 10 CD cord-018225-dozmy3lb 277 22 percent percent NN cord-018225-dozmy3lb 277 23 ) ) -RRB- cord-018225-dozmy3lb 277 24 in in IN cord-018225-dozmy3lb 277 25 the the DT cord-018225-dozmy3lb 277 26 cefotaxime cefotaxime NN cord-018225-dozmy3lb 277 27 - - HYPH cord-018225-dozmy3lb 277 28 plus plus CC cord-018225-dozmy3lb 277 29 - - HYPH cord-018225-dozmy3lb 277 30 albumin albumin NN cord-018225-dozmy3lb 277 31 group group NN cord-018225-dozmy3lb 277 32 ( ( -LRB- cord-018225-dozmy3lb 277 33 p p NN cord-018225-dozmy3lb 277 34 = = SYM cord-018225-dozmy3lb 277 35 0.01 0.01 CD cord-018225-dozmy3lb 277 36 ) ) -RRB- cord-018225-dozmy3lb 277 37 ; ; : cord-018225-dozmy3lb 277 38 at at IN cord-018225-dozmy3lb 277 39 three three CD cord-018225-dozmy3lb 277 40 months month NNS cord-018225-dozmy3lb 277 41 , , , cord-018225-dozmy3lb 277 42 the the DT cord-018225-dozmy3lb 277 43 mortality mortality NN cord-018225-dozmy3lb 277 44 rates rate NNS cord-018225-dozmy3lb 277 45 were be VBD cord-018225-dozmy3lb 277 46 41 41 CD cord-018225-dozmy3lb 277 47 percent percent NN cord-018225-dozmy3lb 277 48 ( ( -LRB- cord-018225-dozmy3lb 277 49 a a DT cord-018225-dozmy3lb 277 50 total total NN cord-018225-dozmy3lb 277 51 of of IN cord-018225-dozmy3lb 277 52 26 26 CD cord-018225-dozmy3lb 277 53 deaths death NNS cord-018225-dozmy3lb 277 54 ) ) -RRB- cord-018225-dozmy3lb 277 55 , , , cord-018225-dozmy3lb 277 56 and and CC cord-018225-dozmy3lb 277 57 22 22 CD cord-018225-dozmy3lb 277 58 % % NN cord-018225-dozmy3lb 277 59 ( ( -LRB- cord-018225-dozmy3lb 277 60 a a DT cord-018225-dozmy3lb 277 61 total total NN cord-018225-dozmy3lb 277 62 of of IN cord-018225-dozmy3lb 277 63 14 14 CD cord-018225-dozmy3lb 277 64 deaths death NNS cord-018225-dozmy3lb 277 65 ) ) -RRB- cord-018225-dozmy3lb 277 66 , , , cord-018225-dozmy3lb 277 67 respectively respectively RB cord-018225-dozmy3lb 277 68 ( ( -LRB- cord-018225-dozmy3lb 277 69 p p NN cord-018225-dozmy3lb 277 70 = = SYM cord-018225-dozmy3lb 277 71 0.03 0.03 CD cord-018225-dozmy3lb 277 72 ) ) -RRB- cord-018225-dozmy3lb 277 73 . . . cord-018225-dozmy3lb 278 1 Patients patient NNS cord-018225-dozmy3lb 278 2 treated treat VBN cord-018225-dozmy3lb 278 3 with with IN cord-018225-dozmy3lb 278 4 cefotaxime cefotaxime NN cord-018225-dozmy3lb 278 5 had have VBD cord-018225-dozmy3lb 278 6 higher high JJR cord-018225-dozmy3lb 278 7 levels level NNS cord-018225-dozmy3lb 278 8 of of IN cord-018225-dozmy3lb 278 9 plasma plasma NN cord-018225-dozmy3lb 278 10 renin renin NN cord-018225-dozmy3lb 278 11 activity activity NN cord-018225-dozmy3lb 278 12 than than IN cord-018225-dozmy3lb 278 13 those those DT cord-018225-dozmy3lb 278 14 treated treat VBN cord-018225-dozmy3lb 278 15 with with IN cord-018225-dozmy3lb 278 16 cefotaxime cefotaxime NN cord-018225-dozmy3lb 278 17 and and CC cord-018225-dozmy3lb 278 18 albumin albumin NN cord-018225-dozmy3lb 278 19 ; ; : cord-018225-dozmy3lb 278 20 patients patient NNS cord-018225-dozmy3lb 278 21 with with IN cord-018225-dozmy3lb 278 22 renal renal JJ cord-018225-dozmy3lb 278 23 impairment impairment NN cord-018225-dozmy3lb 278 24 had have VBD cord-018225-dozmy3lb 278 25 the the DT cord-018225-dozmy3lb 278 26 highest high JJS cord-018225-dozmy3lb 278 27 values value NNS cord-018225-dozmy3lb 278 28 . . . cord-018225-dozmy3lb 279 1 CONCLUSIONS conclusion NNS cord-018225-dozmy3lb 279 2 : : : cord-018225-dozmy3lb 280 1 In in IN cord-018225-dozmy3lb 280 2 patients patient NNS cord-018225-dozmy3lb 280 3 with with IN cord-018225-dozmy3lb 280 4 cirrhosis cirrhosis NN cord-018225-dozmy3lb 280 5 and and CC cord-018225-dozmy3lb 280 6 spontaneous spontaneous JJ cord-018225-dozmy3lb 280 7 bacterial bacterial JJ cord-018225-dozmy3lb 280 8 peritonitis peritonitis NN cord-018225-dozmy3lb 280 9 , , , cord-018225-dozmy3lb 280 10 treatment treatment NN cord-018225-dozmy3lb 280 11 with with IN cord-018225-dozmy3lb 280 12 intravenous intravenous JJ cord-018225-dozmy3lb 280 13 albumin albumin NN cord-018225-dozmy3lb 280 14 in in IN cord-018225-dozmy3lb 280 15 addition addition NN cord-018225-dozmy3lb 280 16 to to IN cord-018225-dozmy3lb 280 17 an an DT cord-018225-dozmy3lb 280 18 antibiotic antibiotic JJ cord-018225-dozmy3lb 280 19 reduces reduce VBZ cord-018225-dozmy3lb 280 20 the the DT cord-018225-dozmy3lb 280 21 incidence incidence NN cord-018225-dozmy3lb 280 22 of of IN cord-018225-dozmy3lb 280 23 renal renal JJ cord-018225-dozmy3lb 280 24 impairment impairment NN cord-018225-dozmy3lb 280 25 and and CC cord-018225-dozmy3lb 280 26 death death NN cord-018225-dozmy3lb 280 27 , , , cord-018225-dozmy3lb 280 28 in in IN cord-018225-dozmy3lb 280 29 comparison comparison NN cord-018225-dozmy3lb 280 30 with with IN cord-018225-dozmy3lb 280 31 treatment treatment NN cord-018225-dozmy3lb 280 32 with with IN cord-018225-dozmy3lb 280 33 an an DT cord-018225-dozmy3lb 280 34 antibiotic antibiotic NN cord-018225-dozmy3lb 280 35 alone alone RB cord-018225-dozmy3lb 280 36 . . . cord-018225-dozmy3lb 281 1 The the DT cord-018225-dozmy3lb 281 2 effect effect NN cord-018225-dozmy3lb 281 3 of of IN cord-018225-dozmy3lb 281 4 intravenous intravenous JJ cord-018225-dozmy3lb 281 5 albumin albumin NN cord-018225-dozmy3lb 281 6 on on IN cord-018225-dozmy3lb 281 7 renal renal JJ cord-018225-dozmy3lb 281 8 impairment impairment NN cord-018225-dozmy3lb 281 9 and and CC cord-018225-dozmy3lb 281 10 mortality mortality NN cord-018225-dozmy3lb 281 11 was be VBD cord-018225-dozmy3lb 281 12 studied study VBN cord-018225-dozmy3lb 281 13 in in IN cord-018225-dozmy3lb 281 14 126 126 CD cord-018225-dozmy3lb 281 15 patients patient NNS cord-018225-dozmy3lb 281 16 with with IN cord-018225-dozmy3lb 281 17 cirrhosis cirrhosis NN cord-018225-dozmy3lb 281 18 and and CC cord-018225-dozmy3lb 281 19 spontaneous spontaneous JJ cord-018225-dozmy3lb 281 20 bacterial bacterial JJ cord-018225-dozmy3lb 281 21 peritonitis peritonitis NN cord-018225-dozmy3lb 281 22 . . . cord-018225-dozmy3lb 282 1 Patients patient NNS cord-018225-dozmy3lb 282 2 were be VBD cord-018225-dozmy3lb 282 3 randomly randomly RB cord-018225-dozmy3lb 282 4 assigned assign VBN cord-018225-dozmy3lb 282 5 to to TO cord-018225-dozmy3lb 282 6 receive receive VB cord-018225-dozmy3lb 282 7 treatment treatment NN cord-018225-dozmy3lb 282 8 with with IN cord-018225-dozmy3lb 282 9 intravenous intravenous JJ cord-018225-dozmy3lb 282 10 cefotaxime cefotaxime NN cord-018225-dozmy3lb 282 11 or or CC cord-018225-dozmy3lb 282 12 cefotaxime cefotaxime NN cord-018225-dozmy3lb 282 13 and and CC cord-018225-dozmy3lb 282 14 intravenous intravenous JJ cord-018225-dozmy3lb 282 15 albumin albumin NN cord-018225-dozmy3lb 282 16 . . . cord-018225-dozmy3lb 283 1 Albumin albumin NN cord-018225-dozmy3lb 283 2 was be VBD cord-018225-dozmy3lb 283 3 given give VBN cord-018225-dozmy3lb 283 4 at at IN cord-018225-dozmy3lb 283 5 a a DT cord-018225-dozmy3lb 283 6 dose dose NN cord-018225-dozmy3lb 283 7 of of IN cord-018225-dozmy3lb 283 8 1.5 1.5 CD cord-018225-dozmy3lb 283 9 g g NN cord-018225-dozmy3lb 283 10 / / SYM cord-018225-dozmy3lb 283 11 kg kg NN cord-018225-dozmy3lb 283 12 body body NN cord-018225-dozmy3lb 283 13 weight weight NN cord-018225-dozmy3lb 283 14 at at IN cord-018225-dozmy3lb 283 15 the the DT cord-018225-dozmy3lb 283 16 time time NN cord-018225-dozmy3lb 283 17 of of IN cord-018225-dozmy3lb 283 18 diagnosis diagnosis NN cord-018225-dozmy3lb 283 19 , , , cord-018225-dozmy3lb 283 20 and and CC cord-018225-dozmy3lb 283 21 1 1 CD cord-018225-dozmy3lb 283 22 g g NN cord-018225-dozmy3lb 283 23 / / SYM cord-018225-dozmy3lb 283 24 kg kg NN cord-018225-dozmy3lb 283 25 on on IN cord-018225-dozmy3lb 283 26 day day NN cord-018225-dozmy3lb 283 27 3 3 CD cord-018225-dozmy3lb 283 28 . . . cord-018225-dozmy3lb 284 1 The the DT cord-018225-dozmy3lb 284 2 infection infection NN cord-018225-dozmy3lb 284 3 resolved resolve VBD cord-018225-dozmy3lb 284 4 in in IN cord-018225-dozmy3lb 284 5 a a DT cord-018225-dozmy3lb 284 6 similar similar JJ cord-018225-dozmy3lb 284 7 number number NN cord-018225-dozmy3lb 284 8 of of IN cord-018225-dozmy3lb 284 9 patients patient NNS cord-018225-dozmy3lb 284 10 in in IN cord-018225-dozmy3lb 284 11 both both DT cord-018225-dozmy3lb 284 12 groups group NNS cord-018225-dozmy3lb 284 13 . . . cord-018225-dozmy3lb 285 1 However however RB cord-018225-dozmy3lb 285 2 , , , cord-018225-dozmy3lb 285 3 the the DT cord-018225-dozmy3lb 285 4 incidence incidence NN cord-018225-dozmy3lb 285 5 of of IN cord-018225-dozmy3lb 285 6 renal renal JJ cord-018225-dozmy3lb 285 7 impairment impairment NN cord-018225-dozmy3lb 285 8 was be VBD cord-018225-dozmy3lb 285 9 very very RB cord-018225-dozmy3lb 285 10 much much RB cord-018225-dozmy3lb 285 11 lower low JJR cord-018225-dozmy3lb 285 12 in in IN cord-018225-dozmy3lb 285 13 the the DT cord-018225-dozmy3lb 285 14 cefotaxime cefotaxime NNP cord-018225-dozmy3lb 285 15 plus plus CC cord-018225-dozmy3lb 285 16 albumin albumin NNP cord-018225-dozmy3lb 285 17 group group NN cord-018225-dozmy3lb 285 18 ( ( -LRB- cord-018225-dozmy3lb 285 19 6 6 CD cord-018225-dozmy3lb 285 20 patients patient NNS cord-018225-dozmy3lb 285 21 ; ; : cord-018225-dozmy3lb 285 22 10 10 CD cord-018225-dozmy3lb 285 23 % % NN cord-018225-dozmy3lb 285 24 ) ) -RRB- cord-018225-dozmy3lb 285 25 than than IN cord-018225-dozmy3lb 285 26 in in IN cord-018225-dozmy3lb 285 27 the the DT cord-018225-dozmy3lb 285 28 cefotaxime cefotaxime NNP cord-018225-dozmy3lb 285 29 alone alone RB cord-018225-dozmy3lb 285 30 group group NN cord-018225-dozmy3lb 285 31 ( ( -LRB- cord-018225-dozmy3lb 285 32 21 21 CD cord-018225-dozmy3lb 285 33 patients patient NNS cord-018225-dozmy3lb 285 34 ; ; : cord-018225-dozmy3lb 285 35 33 33 CD cord-018225-dozmy3lb 285 36 % % NN cord-018225-dozmy3lb 285 37 ) ) -RRB- cord-018225-dozmy3lb 285 38 . . . cord-018225-dozmy3lb 286 1 Furthermore furthermore RB cord-018225-dozmy3lb 286 2 , , , cord-018225-dozmy3lb 286 3 the the DT cord-018225-dozmy3lb 286 4 mortality mortality NN cord-018225-dozmy3lb 286 5 rates rate NNS cord-018225-dozmy3lb 286 6 were be VBD cord-018225-dozmy3lb 286 7 lower low JJR cord-018225-dozmy3lb 286 8 in in IN cord-018225-dozmy3lb 286 9 the the DT cord-018225-dozmy3lb 286 10 cefotaxime cefotaxime NNP cord-018225-dozmy3lb 286 11 plus plus CC cord-018225-dozmy3lb 286 12 albumin albumin NN cord-018225-dozmy3lb 286 13 groups group NNS cord-018225-dozmy3lb 286 14 , , , cord-018225-dozmy3lb 286 15 i.e. i.e. FW cord-018225-dozmy3lb 286 16 6 6 CD cord-018225-dozmy3lb 286 17 patients patient NNS cord-018225-dozmy3lb 286 18 or or CC cord-018225-dozmy3lb 286 19 10 10 CD cord-018225-dozmy3lb 286 20 % % NN cord-018225-dozmy3lb 286 21 vs vs IN cord-018225-dozmy3lb 286 22 18 18 CD cord-018225-dozmy3lb 286 23 patients patient NNS cord-018225-dozmy3lb 286 24 or or CC cord-018225-dozmy3lb 286 25 29 29 CD cord-018225-dozmy3lb 286 26 % % NN cord-018225-dozmy3lb 286 27 for for IN cord-018225-dozmy3lb 286 28 in in IN cord-018225-dozmy3lb 286 29 - - HYPH cord-018225-dozmy3lb 286 30 hospital hospital NN cord-018225-dozmy3lb 286 31 mortality mortality NN cord-018225-dozmy3lb 286 32 , , , cord-018225-dozmy3lb 286 33 and and CC cord-018225-dozmy3lb 286 34 14 14 CD cord-018225-dozmy3lb 286 35 patients patient NNS cord-018225-dozmy3lb 286 36 ( ( -LRB- cord-018225-dozmy3lb 286 37 22 22 CD cord-018225-dozmy3lb 286 38 % % NN cord-018225-dozmy3lb 286 39 ) ) -RRB- cord-018225-dozmy3lb 286 40 and and CC cord-018225-dozmy3lb 286 41 26 26 CD cord-018225-dozmy3lb 286 42 patients patient NNS cord-018225-dozmy3lb 286 43 ( ( -LRB- cord-018225-dozmy3lb 286 44 41 41 CD cord-018225-dozmy3lb 286 45 % % NN cord-018225-dozmy3lb 286 46 ) ) -RRB- cord-018225-dozmy3lb 286 47 at at IN cord-018225-dozmy3lb 286 48 3 3 CD cord-018225-dozmy3lb 286 49 months month NNS cord-018225-dozmy3lb 286 50 . . . cord-018225-dozmy3lb 287 1 The the DT cord-018225-dozmy3lb 287 2 effects effect NNS cord-018225-dozmy3lb 287 3 of of IN cord-018225-dozmy3lb 287 4 whole whole JJ cord-018225-dozmy3lb 287 5 bile bile NN cord-018225-dozmy3lb 287 6 and and CC cord-018225-dozmy3lb 287 7 bile bile NN cord-018225-dozmy3lb 287 8 salts salt NNS cord-018225-dozmy3lb 287 9 on on IN cord-018225-dozmy3lb 287 10 the the DT cord-018225-dozmy3lb 287 11 perfused perfuse VBN cord-018225-dozmy3lb 287 12 heart heart NN cord-018225-dozmy3lb 287 13 Severe severe JJ cord-018225-dozmy3lb 287 14 sinus sinus NN cord-018225-dozmy3lb 287 15 node node NN cord-018225-dozmy3lb 287 16 dysfunction dysfunction NN cord-018225-dozmy3lb 287 17 in in IN cord-018225-dozmy3lb 287 18 obstructive obstructive JJ cord-018225-dozmy3lb 287 19 jaundice jaundice NN cord-018225-dozmy3lb 287 20 Obstructive obstructive JJ cord-018225-dozmy3lb 287 21 jaundice jaundice NN cord-018225-dozmy3lb 287 22 blunts blunt NNS cord-018225-dozmy3lb 287 23 myocardial myocardial JJ cord-018225-dozmy3lb 287 24 contractile contractile JJ cord-018225-dozmy3lb 287 25 response response NN cord-018225-dozmy3lb 287 26 to to IN cord-018225-dozmy3lb 287 27 isoprenaline isoprenaline NNP cord-018225-dozmy3lb 287 28 in in IN cord-018225-dozmy3lb 287 29 the the DT cord-018225-dozmy3lb 287 30 dog dog NN cord-018225-dozmy3lb 287 31 : : : cord-018225-dozmy3lb 288 1 a a DT cord-018225-dozmy3lb 288 2 clue clue NN cord-018225-dozmy3lb 288 3 to to IN cord-018225-dozmy3lb 288 4 the the DT cord-018225-dozmy3lb 288 5 susceptibility susceptibility NN cord-018225-dozmy3lb 288 6 of of IN cord-018225-dozmy3lb 288 7 jaundiced jaundiced JJ cord-018225-dozmy3lb 288 8 patients patient NNS cord-018225-dozmy3lb 288 9 to to TO cord-018225-dozmy3lb 288 10 shock shock VB cord-018225-dozmy3lb 288 11 ? ? . cord-018225-dozmy3lb 289 1 The the DT cord-018225-dozmy3lb 289 2 MEGX MEGX NNP cord-018225-dozmy3lb 289 3 test test NN cord-018225-dozmy3lb 289 4 : : : cord-018225-dozmy3lb 289 5 a a DT cord-018225-dozmy3lb 289 6 tool tool NN cord-018225-dozmy3lb 289 7 for for IN cord-018225-dozmy3lb 289 8 the the DT cord-018225-dozmy3lb 289 9 real real JJ cord-018225-dozmy3lb 289 10 - - HYPH cord-018225-dozmy3lb 289 11 time time NN cord-018225-dozmy3lb 289 12 assessment assessment NN cord-018225-dozmy3lb 289 13 of of IN cord-018225-dozmy3lb 289 14 hepatic hepatic JJ cord-018225-dozmy3lb 289 15 function function NN cord-018225-dozmy3lb 289 16 Liver liver NN cord-018225-dozmy3lb 289 17 function function NN cord-018225-dozmy3lb 289 18 and and CC cord-018225-dozmy3lb 289 19 splanchnic splanchnic JJ cord-018225-dozmy3lb 289 20 ischemia ischemia NN cord-018225-dozmy3lb 289 21 in in IN cord-018225-dozmy3lb 289 22 critically critically RB cord-018225-dozmy3lb 289 23 ill ill JJ cord-018225-dozmy3lb 289 24 patients patient NNS cord-018225-dozmy3lb 290 1 Lignocaine Lignocaine NNP cord-018225-dozmy3lb 290 2 metabolite metabolite NN cord-018225-dozmy3lb 290 3 formation formation NN cord-018225-dozmy3lb 290 4 : : : cord-018225-dozmy3lb 290 5 an an DT cord-018225-dozmy3lb 290 6 indicator indicator NN cord-018225-dozmy3lb 290 7 for for IN cord-018225-dozmy3lb 290 8 liver liver NN cord-018225-dozmy3lb 290 9 dysfunction dysfunction NN cord-018225-dozmy3lb 290 10 and and CC cord-018225-dozmy3lb 290 11 predictor predictor NN cord-018225-dozmy3lb 290 12 of of IN cord-018225-dozmy3lb 290 13 survival survival NN cord-018225-dozmy3lb 290 14 in in IN cord-018225-dozmy3lb 290 15 surgical surgical JJ cord-018225-dozmy3lb 290 16 intensive intensive JJ cord-018225-dozmy3lb 290 17 care care NN cord-018225-dozmy3lb 290 18 patients patient NNS cord-018225-dozmy3lb 290 19 Assessment Assessment NNP cord-018225-dozmy3lb 290 20 of of IN cord-018225-dozmy3lb 290 21 prognosis prognosis NN cord-018225-dozmy3lb 290 22 in in IN cord-018225-dozmy3lb 290 23 fulminant fulminant JJ cord-018225-dozmy3lb 290 24 hepatic hepatic JJ cord-018225-dozmy3lb 290 25 failure failure NN cord-018225-dozmy3lb 290 26 Multivariate multivariate JJ cord-018225-dozmy3lb 290 27 analysis analysis NN cord-018225-dozmy3lb 290 28 of of IN cord-018225-dozmy3lb 290 29 prognostic prognostic JJ cord-018225-dozmy3lb 290 30 factors factor NNS cord-018225-dozmy3lb 290 31 in in IN cord-018225-dozmy3lb 290 32 fulminant fulminant JJ cord-018225-dozmy3lb 290 33 hepatitis hepatitis NN cord-018225-dozmy3lb 290 34 B B NNP cord-018225-dozmy3lb 290 35 Early early JJ cord-018225-dozmy3lb 290 36 indicators indicator NNS cord-018225-dozmy3lb 290 37 of of IN cord-018225-dozmy3lb 290 38 prognosis prognosis NN cord-018225-dozmy3lb 290 39 in in IN cord-018225-dozmy3lb 290 40 fulminant fulminant JJ cord-018225-dozmy3lb 290 41 hepatic hepatic JJ cord-018225-dozmy3lb 290 42 failure failure NN cord-018225-dozmy3lb 290 43 : : : cord-018225-dozmy3lb 290 44 and and CC cord-018225-dozmy3lb 290 45 assessment assessment NN cord-018225-dozmy3lb 290 46 of of IN cord-018225-dozmy3lb 290 47 the the DT cord-018225-dozmy3lb 290 48 King King NNP cord-018225-dozmy3lb 290 49 's 's POS cord-018225-dozmy3lb 290 50 criteria criterion NNS cord-018225-dozmy3lb 290 51 Liver liver NN cord-018225-dozmy3lb 290 52 transplantation transplantation NN cord-018225-dozmy3lb 290 53 in in IN cord-018225-dozmy3lb 290 54 Europe Europe NNP cord-018225-dozmy3lb 290 55 for for IN cord-018225-dozmy3lb 290 56 patients patient NNS cord-018225-dozmy3lb 290 57 with with IN cord-018225-dozmy3lb 290 58 acute acute JJ cord-018225-dozmy3lb 290 59 liver liver NN cord-018225-dozmy3lb 290 60 failure failure NN cord-018225-dozmy3lb 291 1 The the DT cord-018225-dozmy3lb 291 2 effect effect NN cord-018225-dozmy3lb 291 3 of of IN cord-018225-dozmy3lb 291 4 n n NN cord-018225-dozmy3lb 291 5 - - NN cord-018225-dozmy3lb 291 6 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 291 7 on on IN cord-018225-dozmy3lb 291 8 oxygen oxygen NN cord-018225-dozmy3lb 291 9 transport transport NN cord-018225-dozmy3lb 291 10 and and CC cord-018225-dozmy3lb 291 11 uptake uptake NN cord-018225-dozmy3lb 291 12 in in IN cord-018225-dozmy3lb 291 13 patients patient NNS cord-018225-dozmy3lb 291 14 with with IN cord-018225-dozmy3lb 291 15 fulminant fulminant JJ cord-018225-dozmy3lb 291 16 hepatic hepatic JJ cord-018225-dozmy3lb 291 17 failure failure NN cord-018225-dozmy3lb 292 1 Improved improved JJ cord-018225-dozmy3lb 292 2 outcome outcome NN cord-018225-dozmy3lb 292 3 of of IN cord-018225-dozmy3lb 292 4 paracetamol paracetamol NN cord-018225-dozmy3lb 292 5 - - HYPH cord-018225-dozmy3lb 292 6 induced induce VBN cord-018225-dozmy3lb 292 7 fulminant fulminant JJ cord-018225-dozmy3lb 292 8 hepatic hepatic JJ cord-018225-dozmy3lb 292 9 failure failure NN cord-018225-dozmy3lb 292 10 by by IN cord-018225-dozmy3lb 292 11 late late JJ cord-018225-dozmy3lb 292 12 administration administration NN cord-018225-dozmy3lb 292 13 of of IN cord-018225-dozmy3lb 292 14 acetylcysteine acetylcysteine NNP cord-018225-dozmy3lb 292 15 N N NNP cord-018225-dozmy3lb 292 16 - - HYPH cord-018225-dozmy3lb 292 17 acetylcysteine acetylcysteine NN cord-018225-dozmy3lb 292 18 increases increase VBZ cord-018225-dozmy3lb 292 19 liver liver NN cord-018225-dozmy3lb 292 20 blood blood NN cord-018225-dozmy3lb 292 21 flow flow NN cord-018225-dozmy3lb 292 22 and and CC cord-018225-dozmy3lb 292 23 improves improve VBZ cord-018225-dozmy3lb 292 24 liver liver NN cord-018225-dozmy3lb 292 25 function function NN cord-018225-dozmy3lb 292 26 in in IN cord-018225-dozmy3lb 292 27 septic septic JJ cord-018225-dozmy3lb 292 28 shock shock NN cord-018225-dozmy3lb 292 29 patients patient NNS cord-018225-dozmy3lb 292 30 : : : cord-018225-dozmy3lb 292 31 results result NNS cord-018225-dozmy3lb 292 32 of of IN cord-018225-dozmy3lb 292 33 a a DT cord-018225-dozmy3lb 292 34 prospective prospective JJ cord-018225-dozmy3lb 292 35 , , , cord-018225-dozmy3lb 292 36 randomised randomised JJ cord-018225-dozmy3lb 292 37 , , , cord-018225-dozmy3lb 292 38 double double JJ cord-018225-dozmy3lb 292 39 - - HYPH cord-018225-dozmy3lb 292 40 blind blind JJ cord-018225-dozmy3lb 292 41 study study NN cord-018225-dozmy3lb 292 42 Molecular Molecular NNP cord-018225-dozmy3lb 292 43 adsorbent adsorbent JJ cord-018225-dozmy3lb 292 44 recycling recycling NN cord-018225-dozmy3lb 292 45 system system NN cord-018225-dozmy3lb 292 46 ( ( -LRB- cord-018225-dozmy3lb 292 47 MARS MARS NNP cord-018225-dozmy3lb 292 48 ) ) -RRB- cord-018225-dozmy3lb 292 49 : : : cord-018225-dozmy3lb 293 1 clinical clinical JJ cord-018225-dozmy3lb 293 2 results result NNS cord-018225-dozmy3lb 293 3 of of IN cord-018225-dozmy3lb 293 4 a a DT cord-018225-dozmy3lb 293 5 new new JJ cord-018225-dozmy3lb 293 6 - - HYPH cord-018225-dozmy3lb 293 7 membrane membrane NN cord-018225-dozmy3lb 293 8 - - HYPH cord-018225-dozmy3lb 293 9 based base VBN cord-018225-dozmy3lb 293 10 blood blood NN cord-018225-dozmy3lb 293 11 purification purification NN cord-018225-dozmy3lb 293 12 system system NN cord-018225-dozmy3lb 293 13 for for IN cord-018225-dozmy3lb 293 14 bioartificial bioartificial JJ cord-018225-dozmy3lb 293 15 liver liver NN cord-018225-dozmy3lb 293 16 support support NN cord-018225-dozmy3lb 293 17 Extracorporeal extracorporeal JJ cord-018225-dozmy3lb 293 18 liver liver NN cord-018225-dozmy3lb 293 19 support support NN cord-018225-dozmy3lb 293 20 : : : cord-018225-dozmy3lb 293 21 cell cell NN cord-018225-dozmy3lb 293 22 - - HYPH cord-018225-dozmy3lb 293 23 based base VBN cord-018225-dozmy3lb 293 24 therapy therapy NN cord-018225-dozmy3lb 293 25 for for IN cord-018225-dozmy3lb 293 26 the the DT cord-018225-dozmy3lb 293 27 failing fail VBG cord-018225-dozmy3lb 293 28 liver liver NN cord-018225-dozmy3lb 293 29 Key key JJ cord-018225-dozmy3lb 293 30 message message NN cord-018225-dozmy3lb 293 31 Complex complex JJ cord-018225-dozmy3lb 293 32 forms form NNS cord-018225-dozmy3lb 293 33 of of IN cord-018225-dozmy3lb 293 34 extracorporeal extracorporeal JJ cord-018225-dozmy3lb 293 35 perfusion perfusion NN cord-018225-dozmy3lb 293 36 are be VBP cord-018225-dozmy3lb 293 37 possible possible JJ cord-018225-dozmy3lb 293 38 in in IN cord-018225-dozmy3lb 293 39 critically critically RB cord-018225-dozmy3lb 293 40 ill ill JJ cord-018225-dozmy3lb 293 41 patients patient NNS cord-018225-dozmy3lb 293 42 with with IN cord-018225-dozmy3lb 293 43 acute acute JJ cord-018225-dozmy3lb 293 44 liver liver NN cord-018225-dozmy3lb 293 45 failure failure NN cord-018225-dozmy3lb 293 46 and and CC cord-018225-dozmy3lb 293 47 advanced advanced JJ cord-018225-dozmy3lb 293 48 encephalopathy encephalopathy NN cord-018225-dozmy3lb 293 49 . . . cord-018225-dozmy3lb 294 1 A a DT cord-018225-dozmy3lb 294 2 focus focus NN cord-018225-dozmy3lb 294 3 on on IN cord-018225-dozmy3lb 294 4 metabolic metabolic JJ cord-018225-dozmy3lb 294 5 support support NN cord-018225-dozmy3lb 294 6 ( ( -LRB- cord-018225-dozmy3lb 294 7 for for IN cord-018225-dozmy3lb 294 8 example example NN cord-018225-dozmy3lb 294 9 from from IN cord-018225-dozmy3lb 294 10 functioning function VBG cord-018225-dozmy3lb 294 11 hepatocytes hepatocyte NNS cord-018225-dozmy3lb 294 12 ) ) -RRB- cord-018225-dozmy3lb 294 13 rather rather RB cord-018225-dozmy3lb 294 14 than than IN cord-018225-dozmy3lb 294 15 blood blood NN cord-018225-dozmy3lb 294 16 purification purification NN cord-018225-dozmy3lb 294 17 will will MD cord-018225-dozmy3lb 294 18 most most RBS cord-018225-dozmy3lb 294 19 likely likely RB cord-018225-dozmy3lb 294 20 be be VB cord-018225-dozmy3lb 294 21 successful successful JJ cord-018225-dozmy3lb 294 22 Spontaneous spontaneous JJ cord-018225-dozmy3lb 294 23 bacterial bacterial JJ cord-018225-dozmy3lb 294 24 peritonitis peritonitis NN cord-018225-dozmy3lb 294 25 Bacterial bacterial JJ cord-018225-dozmy3lb 294 26 infections infection NNS cord-018225-dozmy3lb 294 27 in in IN cord-018225-dozmy3lb 294 28 liver liver NN cord-018225-dozmy3lb 294 29 disease disease NN cord-018225-dozmy3lb 294 30 Definition definition NN cord-018225-dozmy3lb 294 31 and and CC cord-018225-dozmy3lb 294 32 diagnostic diagnostic JJ cord-018225-dozmy3lb 294 33 criteria criterion NNS cord-018225-dozmy3lb 294 34 of of IN cord-018225-dozmy3lb 294 35 refractory refractory JJ cord-018225-dozmy3lb 294 36 ascites ascites NN cord-018225-dozmy3lb 294 37 and and CC cord-018225-dozmy3lb 294 38 hepatorenal hepatorenal JJ cord-018225-dozmy3lb 294 39 syndrome syndrome NN cord-018225-dozmy3lb 294 40 in in IN cord-018225-dozmy3lb 294 41 cirrhosis cirrhosis NN cord-018225-dozmy3lb 294 42 . . . cord-018225-dozmy3lb 295 1 International International NNP cord-018225-dozmy3lb 295 2 Ascites Ascites NNPS cord-018225-dozmy3lb 295 3 Club Club NNP cord-018225-dozmy3lb 296 1 The the DT cord-018225-dozmy3lb 296 2 case case NN cord-018225-dozmy3lb 296 3 is be VBZ cord-018225-dozmy3lb 296 4 reported report VBN cord-018225-dozmy3lb 296 5 of of IN cord-018225-dozmy3lb 296 6 a a DT cord-018225-dozmy3lb 296 7 29-year 29-year JJ cord-018225-dozmy3lb 296 8 - - HYPH cord-018225-dozmy3lb 296 9 old old JJ cord-018225-dozmy3lb 296 10 woman woman NN cord-018225-dozmy3lb 296 11 who who WP cord-018225-dozmy3lb 296 12 developed develop VBD cord-018225-dozmy3lb 296 13 presumptive presumptive JJ cord-018225-dozmy3lb 296 14 viral viral JJ cord-018225-dozmy3lb 296 15 hepatitis hepatitis NN cord-018225-dozmy3lb 296 16 . . . cord-018225-dozmy3lb 297 1 Her -PRON- PRP$ cord-018225-dozmy3lb 297 2 jaundice jaundice NN cord-018225-dozmy3lb 297 3 initially initially RB cord-018225-dozmy3lb 297 4 resolved resolve VBD cord-018225-dozmy3lb 297 5 after after IN cord-018225-dozmy3lb 297 6 6 6 CD cord-018225-dozmy3lb 297 7 weeks week NNS cord-018225-dozmy3lb 297 8 , , , cord-018225-dozmy3lb 297 9 but but CC cord-018225-dozmy3lb 297 10 recurred recur VBD cord-018225-dozmy3lb 297 11 soon soon RB cord-018225-dozmy3lb 297 12 after after RB cord-018225-dozmy3lb 297 13 and and CC cord-018225-dozmy3lb 297 14 was be VBD cord-018225-dozmy3lb 297 15 accompanied accompany VBN cord-018225-dozmy3lb 297 16 by by IN cord-018225-dozmy3lb 297 17 a a DT cord-018225-dozmy3lb 297 18 flapping flap VBG cord-018225-dozmy3lb 297 19 tremor tremor NN cord-018225-dozmy3lb 297 20 . . . cord-018225-dozmy3lb 298 1 Her -PRON- PRP$ cord-018225-dozmy3lb 298 2 neurological neurological JJ cord-018225-dozmy3lb 298 3 state state NN cord-018225-dozmy3lb 298 4 deteriorated deteriorate VBD cord-018225-dozmy3lb 298 5 markedly markedly RB cord-018225-dozmy3lb 298 6 to to IN cord-018225-dozmy3lb 298 7 grade grade NN cord-018225-dozmy3lb 298 8 IV IV NNP cord-018225-dozmy3lb 298 9 encephalopathy encephalopathy NN cord-018225-dozmy3lb 298 10 . . . cord-018225-dozmy3lb 299 1 She -PRON- PRP cord-018225-dozmy3lb 299 2 was be VBD cord-018225-dozmy3lb 299 3 treated treat VBN cord-018225-dozmy3lb 299 4 with with IN cord-018225-dozmy3lb 299 5 a a DT cord-018225-dozmy3lb 299 6 regimen regimen NN cord-018225-dozmy3lb 299 7 of of IN cord-018225-dozmy3lb 299 8 daily daily JJ cord-018225-dozmy3lb 299 9 exchange exchange NN cord-018225-dozmy3lb 299 10 transfusion transfusion NN cord-018225-dozmy3lb 299 11 for for IN cord-018225-dozmy3lb 299 12 6 6 CD cord-018225-dozmy3lb 299 13 days day NNS cord-018225-dozmy3lb 299 14 , , , cord-018225-dozmy3lb 299 15 but but CC cord-018225-dozmy3lb 299 16 despite despite IN cord-018225-dozmy3lb 299 17 some some DT cord-018225-dozmy3lb 299 18 apparent apparent JJ cord-018225-dozmy3lb 299 19 improvement improvement NN cord-018225-dozmy3lb 299 20 related relate VBN cord-018225-dozmy3lb 299 21 to to IN cord-018225-dozmy3lb 299 22 these these DT cord-018225-dozmy3lb 299 23 procedures procedure NNS cord-018225-dozmy3lb 299 24 , , , cord-018225-dozmy3lb 299 25 this this DT cord-018225-dozmy3lb 299 26 was be VBD cord-018225-dozmy3lb 299 27 not not RB cord-018225-dozmy3lb 299 28 sustained sustain VBN cord-018225-dozmy3lb 299 29 . . . cord-018225-dozmy3lb 300 1 She -PRON- PRP cord-018225-dozmy3lb 300 2 duly duly RB cord-018225-dozmy3lb 300 3 became become VBD cord-018225-dozmy3lb 300 4 apneic apneic JJ cord-018225-dozmy3lb 300 5 , , , cord-018225-dozmy3lb 300 6 and and CC cord-018225-dozmy3lb 300 7 after after IN cord-018225-dozmy3lb 300 8 an an DT cord-018225-dozmy3lb 300 9 unsuccessful unsuccessful JJ cord-018225-dozmy3lb 300 10 seventh seventh JJ cord-018225-dozmy3lb 300 11 exchange exchange NN cord-018225-dozmy3lb 300 12 transfusion transfusion NN cord-018225-dozmy3lb 300 13 , , , cord-018225-dozmy3lb 300 14 she -PRON- PRP cord-018225-dozmy3lb 300 15 underwent undergo VBD cord-018225-dozmy3lb 300 16 cross cross NN cord-018225-dozmy3lb 300 17 - - NN cord-018225-dozmy3lb 300 18 circulation circulation NN cord-018225-dozmy3lb 300 19 with with IN cord-018225-dozmy3lb 300 20 a a DT cord-018225-dozmy3lb 300 21 baboon baboon NN cord-018225-dozmy3lb 300 22 . . . cord-018225-dozmy3lb 301 1 The the DT cord-018225-dozmy3lb 301 2 baboon baboon NN cord-018225-dozmy3lb 301 3 had have VBD cord-018225-dozmy3lb 301 4 been be VBN cord-018225-dozmy3lb 301 5 especially especially RB cord-018225-dozmy3lb 301 6 prepared prepare VBN cord-018225-dozmy3lb 301 7 by by IN cord-018225-dozmy3lb 301 8 washing wash VBG cord-018225-dozmy3lb 301 9 out out RP cord-018225-dozmy3lb 301 10 the the DT cord-018225-dozmy3lb 301 11 blood blood NN cord-018225-dozmy3lb 301 12 volume volume NN cord-018225-dozmy3lb 301 13 with with IN cord-018225-dozmy3lb 301 14 lactate lactate NN cord-018225-dozmy3lb 301 15 solution solution NN cord-018225-dozmy3lb 301 16 under under IN cord-018225-dozmy3lb 301 17 hypothermia hypothermia NN cord-018225-dozmy3lb 301 18 on on IN cord-018225-dozmy3lb 301 19 bypass bypass NN cord-018225-dozmy3lb 301 20 , , , cord-018225-dozmy3lb 301 21 and and CC cord-018225-dozmy3lb 301 22 then then RB cord-018225-dozmy3lb 301 23 replacing replace VBG cord-018225-dozmy3lb 301 24 the the DT cord-018225-dozmy3lb 301 25 blood blood NN cord-018225-dozmy3lb 301 26 volume volume NN cord-018225-dozmy3lb 301 27 with with IN cord-018225-dozmy3lb 301 28 human human JJ cord-018225-dozmy3lb 301 29 blood blood NN cord-018225-dozmy3lb 301 30 compatible compatible JJ cord-018225-dozmy3lb 301 31 with with IN cord-018225-dozmy3lb 301 32 the the DT cord-018225-dozmy3lb 301 33 patient patient NN cord-018225-dozmy3lb 301 34 . . . cord-018225-dozmy3lb 302 1 After after IN cord-018225-dozmy3lb 302 2 about about RB cord-018225-dozmy3lb 302 3 12 12 CD cord-018225-dozmy3lb 302 4 hours hour NNS cord-018225-dozmy3lb 302 5 , , , cord-018225-dozmy3lb 302 6 spontaneous spontaneous JJ cord-018225-dozmy3lb 302 7 ventilation ventilation NN cord-018225-dozmy3lb 302 8 returned return VBD cord-018225-dozmy3lb 302 9 , , , cord-018225-dozmy3lb 302 10 and and CC cord-018225-dozmy3lb 302 11 there there EX cord-018225-dozmy3lb 302 12 was be VBD cord-018225-dozmy3lb 302 13 an an DT cord-018225-dozmy3lb 302 14 improvement improvement NN cord-018225-dozmy3lb 302 15 in in IN cord-018225-dozmy3lb 302 16 conscious conscious JJ cord-018225-dozmy3lb 302 17 state state NN cord-018225-dozmy3lb 302 18 and and CC cord-018225-dozmy3lb 302 19 the the DT cord-018225-dozmy3lb 302 20 treatment treatment NN cord-018225-dozmy3lb 302 21 was be VBD cord-018225-dozmy3lb 302 22 terminated terminate VBN cord-018225-dozmy3lb 302 23 . . . cord-018225-dozmy3lb 303 1 She -PRON- PRP cord-018225-dozmy3lb 303 2 remained remain VBD cord-018225-dozmy3lb 303 3 neurologically neurologically RB cord-018225-dozmy3lb 303 4 impaired impaired JJ cord-018225-dozmy3lb 303 5 for for IN cord-018225-dozmy3lb 303 6 two two CD cord-018225-dozmy3lb 303 7 further further JJ cord-018225-dozmy3lb 303 8 days day NNS cord-018225-dozmy3lb 303 9 , , , cord-018225-dozmy3lb 303 10 and and CC cord-018225-dozmy3lb 303 11 then then RB cord-018225-dozmy3lb 303 12 improved improve VBD cord-018225-dozmy3lb 303 13 markedly markedly RB cord-018225-dozmy3lb 303 14 to to TO cord-018225-dozmy3lb 303 15 become become VB cord-018225-dozmy3lb 303 16 fully fully RB cord-018225-dozmy3lb 303 17 conscious conscious JJ cord-018225-dozmy3lb 303 18 with with IN cord-018225-dozmy3lb 303 19 no no DT cord-018225-dozmy3lb 303 20 abnormal abnormal JJ cord-018225-dozmy3lb 303 21 neurological neurological JJ cord-018225-dozmy3lb 303 22 signs sign NNS cord-018225-dozmy3lb 303 23 . . . cord-018225-dozmy3lb 304 1 Her -PRON- PRP$ cord-018225-dozmy3lb 304 2 improvement improvement NN cord-018225-dozmy3lb 304 3 persisted persist VBD cord-018225-dozmy3lb 304 4 until until IN cord-018225-dozmy3lb 304 5 publication publication NN cord-018225-dozmy3lb 304 6 of of IN cord-018225-dozmy3lb 304 7 the the DT cord-018225-dozmy3lb 304 8 case case NN cord-018225-dozmy3lb 304 9 report report NN cord-018225-dozmy3lb 304 10 . . . cord-018225-dozmy3lb 305 1 Patients patient NNS cord-018225-dozmy3lb 305 2 treated treat VBN cord-018225-dozmy3lb 305 3 with with IN cord-018225-dozmy3lb 305 4 cefotaxime cefotaxime NN cord-018225-dozmy3lb 305 5 had have VBD cord-018225-dozmy3lb 305 6 higher high JJR cord-018225-dozmy3lb 305 7 levels level NNS cord-018225-dozmy3lb 305 8 of of IN cord-018225-dozmy3lb 305 9 plasma plasma NN cord-018225-dozmy3lb 305 10 renin renin NN cord-018225-dozmy3lb 305 11 activity activity NN cord-018225-dozmy3lb 305 12 than than IN cord-018225-dozmy3lb 305 13 those those DT cord-018225-dozmy3lb 305 14 treated treat VBN cord-018225-dozmy3lb 305 15 with with IN cord-018225-dozmy3lb 305 16 cefotaxime cefotaxime NN cord-018225-dozmy3lb 305 17 and and CC cord-018225-dozmy3lb 305 18 albumin albumin NN cord-018225-dozmy3lb 305 19 , , , cord-018225-dozmy3lb 305 20 and and CC cord-018225-dozmy3lb 305 21 patients patient NNS cord-018225-dozmy3lb 305 22 with with IN cord-018225-dozmy3lb 305 23 renal renal JJ cord-018225-dozmy3lb 305 24 impairment impairment NN cord-018225-dozmy3lb 305 25 had have VBD cord-018225-dozmy3lb 305 26 the the DT cord-018225-dozmy3lb 305 27 highest high JJS cord-018225-dozmy3lb 305 28 values value NNS cord-018225-dozmy3lb 305 29 . . . cord-018225-dozmy3lb 306 1 The the DT cord-018225-dozmy3lb 306 2 authors author NNS cord-018225-dozmy3lb 306 3 conclude conclude VBP cord-018225-dozmy3lb 306 4 that that IN cord-018225-dozmy3lb 306 5 in in IN cord-018225-dozmy3lb 306 6 patients patient NNS cord-018225-dozmy3lb 306 7 with with IN cord-018225-dozmy3lb 306 8 cirrhosis cirrhosis NN cord-018225-dozmy3lb 306 9 and and CC cord-018225-dozmy3lb 306 10 spontaneous spontaneous JJ cord-018225-dozmy3lb 306 11 bacterial bacterial JJ cord-018225-dozmy3lb 306 12 peritonitis peritonitis NN cord-018225-dozmy3lb 306 13 , , , cord-018225-dozmy3lb 306 14 treatment treatment NN cord-018225-dozmy3lb 306 15 with with IN cord-018225-dozmy3lb 306 16 intravenous intravenous JJ cord-018225-dozmy3lb 306 17 albumin albumin NN cord-018225-dozmy3lb 306 18 in in IN cord-018225-dozmy3lb 306 19 addition addition NN cord-018225-dozmy3lb 306 20 to to IN cord-018225-dozmy3lb 306 21 an an DT cord-018225-dozmy3lb 306 22 antibiotic antibiotic JJ cord-018225-dozmy3lb 306 23 reduces reduce VBZ cord-018225-dozmy3lb 306 24 the the DT cord-018225-dozmy3lb 306 25 incidence incidence NN cord-018225-dozmy3lb 306 26 of of IN cord-018225-dozmy3lb 306 27 renal renal JJ cord-018225-dozmy3lb 306 28 impairment impairment NN cord-018225-dozmy3lb 306 29 and and CC cord-018225-dozmy3lb 306 30 death death NN cord-018225-dozmy3lb 306 31 in in IN cord-018225-dozmy3lb 306 32 comparison comparison NN cord-018225-dozmy3lb 306 33 with with IN cord-018225-dozmy3lb 306 34 an an DT cord-018225-dozmy3lb 306 35 antibiotic antibiotic NN cord-018225-dozmy3lb 306 36 alone alone RB cord-018225-dozmy3lb 306 37 . . . cord-018225-dozmy3lb 307 1 Spontaneous spontaneous JJ cord-018225-dozmy3lb 307 2 bacterial bacterial JJ cord-018225-dozmy3lb 307 3 peritonitis peritonitis NN cord-018225-dozmy3lb 307 4 is be VBZ cord-018225-dozmy3lb 307 5 a a DT cord-018225-dozmy3lb 307 6 common common JJ cord-018225-dozmy3lb 307 7 complication complication NN cord-018225-dozmy3lb 307 8 in in IN cord-018225-dozmy3lb 307 9 patients patient NNS cord-018225-dozmy3lb 307 10 with with IN cord-018225-dozmy3lb 307 11 cirrhosis cirrhosis NN cord-018225-dozmy3lb 307 12 and and CC cord-018225-dozmy3lb 307 13 ascites ascites NN cord-018225-dozmy3lb 307 14 , , , cord-018225-dozmy3lb 307 15 and and CC cord-018225-dozmy3lb 307 16 may may MD cord-018225-dozmy3lb 307 17 be be VB cord-018225-dozmy3lb 307 18 accompanied accompany VBN cord-018225-dozmy3lb 307 19 by by IN cord-018225-dozmy3lb 307 20 renal renal JJ cord-018225-dozmy3lb 307 21 impairment impairment NN cord-018225-dozmy3lb 307 22 , , , cord-018225-dozmy3lb 307 23 development development NN cord-018225-dozmy3lb 307 24 or or CC cord-018225-dozmy3lb 307 25 worsening worsening NN cord-018225-dozmy3lb 307 26 of of IN cord-018225-dozmy3lb 307 27 encephalopathy encephalopathy NN cord-018225-dozmy3lb 307 28 , , , cord-018225-dozmy3lb 307 29 and and CC cord-018225-dozmy3lb 307 30 increased increase VBN cord-018225-dozmy3lb 307 31 risk risk NN cord-018225-dozmy3lb 307 32 of of IN cord-018225-dozmy3lb 307 33 death death NN cord-018225-dozmy3lb 307 34 . . . cord-018225-dozmy3lb 308 1 Treatment treatment NN cord-018225-dozmy3lb 308 2 with with IN cord-018225-dozmy3lb 308 3 non non JJ cord-018225-dozmy3lb 308 4 - - JJ cord-018225-dozmy3lb 308 5 nephrotoxic nephrotoxic JJ cord-018225-dozmy3lb 308 6 antibiotics antibiotic NNS cord-018225-dozmy3lb 308 7 has have VBZ cord-018225-dozmy3lb 308 8 been be VBN cord-018225-dozmy3lb 308 9 associated associate VBN cord-018225-dozmy3lb 308 10 with with IN cord-018225-dozmy3lb 308 11 improved improved JJ cord-018225-dozmy3lb 308 12 outcome outcome NN cord-018225-dozmy3lb 308 13 , , , cord-018225-dozmy3lb 308 14 but but CC cord-018225-dozmy3lb 308 15 volume volume NN cord-018225-dozmy3lb 308 16 expansion expansion NN cord-018225-dozmy3lb 308 17 with with IN cord-018225-dozmy3lb 308 18 albumin albumin NN cord-018225-dozmy3lb 308 19 in in IN cord-018225-dozmy3lb 308 20 addition addition NN cord-018225-dozmy3lb 308 21 to to IN cord-018225-dozmy3lb 308 22 antibiotics antibiotic NNS cord-018225-dozmy3lb 308 23 results result NNS cord-018225-dozmy3lb 308 24 in in IN cord-018225-dozmy3lb 308 25 further further JJ cord-018225-dozmy3lb 308 26 improvement improvement NN cord-018225-dozmy3lb 308 27 in in IN cord-018225-dozmy3lb 308 28 survival survival NN cord-018225-dozmy3lb 308 29 and and CC cord-018225-dozmy3lb 308 30 a a DT cord-018225-dozmy3lb 308 31 reduced reduce VBN cord-018225-dozmy3lb 308 32 incidence incidence NN cord-018225-dozmy3lb 308 33 of of IN cord-018225-dozmy3lb 308 34 renal renal JJ cord-018225-dozmy3lb 308 35 impairment impairment NN cord-018225-dozmy3lb 308 36 . . . cord-018225-dozmy3lb 309 1 The the DT cord-018225-dozmy3lb 309 2 most most RBS cord-018225-dozmy3lb 309 3 likely likely JJ cord-018225-dozmy3lb 309 4 explanation explanation NN cord-018225-dozmy3lb 309 5 is be VBZ cord-018225-dozmy3lb 309 6 that that IN cord-018225-dozmy3lb 309 7 albumin albumin NN cord-018225-dozmy3lb 309 8 infusion infusion NN cord-018225-dozmy3lb 309 9 prevents prevent VBZ cord-018225-dozmy3lb 309 10 hypovolemia hypovolemia NN cord-018225-dozmy3lb 309 11 and and CC cord-018225-dozmy3lb 309 12 the the DT cord-018225-dozmy3lb 309 13 subsequent subsequent JJ cord-018225-dozmy3lb 309 14 activation activation NN cord-018225-dozmy3lb 309 15 of of IN cord-018225-dozmy3lb 309 16 vasoconstrictor vasoconstrictor NN cord-018225-dozmy3lb 309 17 systems system NNS cord-018225-dozmy3lb 309 18 . . . cord-018225-dozmy3lb 310 1 However however RB cord-018225-dozmy3lb 310 2 , , , cord-018225-dozmy3lb 310 3 mechanisms mechanism NNS cord-018225-dozmy3lb 310 4 unrelated unrelated JJ cord-018225-dozmy3lb 310 5 to to IN cord-018225-dozmy3lb 310 6 plasma plasma NN cord-018225-dozmy3lb 310 7 expansion expansion NN cord-018225-dozmy3lb 310 8 can can MD cord-018225-dozmy3lb 310 9 not not RB cord-018225-dozmy3lb 310 10 be be VB cord-018225-dozmy3lb 310 11 ruled rule VBN cord-018225-dozmy3lb 310 12 out out RP cord-018225-dozmy3lb 310 13 . . . cord-018225-dozmy3lb 311 1 This this DT cord-018225-dozmy3lb 311 2 study study NN cord-018225-dozmy3lb 311 3 provides provide VBZ cord-018225-dozmy3lb 311 4 strong strong JJ cord-018225-dozmy3lb 311 5 evidence evidence NN cord-018225-dozmy3lb 311 6 that that IN cord-018225-dozmy3lb 311 7 intravenous intravenous JJ cord-018225-dozmy3lb 311 8 albumin albumin NN cord-018225-dozmy3lb 311 9 therapy therapy NN cord-018225-dozmy3lb 311 10 should should MD cord-018225-dozmy3lb 311 11 be be VB cord-018225-dozmy3lb 311 12 given give VBN cord-018225-dozmy3lb 311 13 , , , cord-018225-dozmy3lb 311 14 in in IN cord-018225-dozmy3lb 311 15 addition addition NN cord-018225-dozmy3lb 311 16 to to IN cord-018225-dozmy3lb 311 17 antibiotic antibiotic JJ cord-018225-dozmy3lb 311 18 therapy therapy NN cord-018225-dozmy3lb 311 19 , , , cord-018225-dozmy3lb 311 20 to to IN cord-018225-dozmy3lb 311 21 patients patient NNS cord-018225-dozmy3lb 311 22 with with IN cord-018225-dozmy3lb 311 23 cirrhosis cirrhosis NN cord-018225-dozmy3lb 311 24 and and CC cord-018225-dozmy3lb 311 25 spontaneous spontaneous JJ cord-018225-dozmy3lb 311 26 bacterial bacterial JJ cord-018225-dozmy3lb 311 27 peritonitis peritonitis NN cord-018225-dozmy3lb 311 28 . . . cord-018225-dozmy3lb 312 1 The the DT cord-018225-dozmy3lb 312 2 effects effect NNS cord-018225-dozmy3lb 312 3 of of IN cord-018225-dozmy3lb 312 4 albumin albumin NN cord-018225-dozmy3lb 312 5 therapy therapy NN cord-018225-dozmy3lb 312 6 are be VBP cord-018225-dozmy3lb 312 7 not not RB cord-018225-dozmy3lb 312 8 known know VBN cord-018225-dozmy3lb 312 9 in in IN cord-018225-dozmy3lb 312 10 patients patient NNS cord-018225-dozmy3lb 312 11 with with IN cord-018225-dozmy3lb 312 12 organic organic JJ cord-018225-dozmy3lb 312 13 nephropathy nephropathy NN cord-018225-dozmy3lb 312 14 and and CC cord-018225-dozmy3lb 312 15 serum serum NN cord-018225-dozmy3lb 312 16 creatinine creatinine NN cord-018225-dozmy3lb 312 17 concentration concentration NN cord-018225-dozmy3lb 312 18 > > XX cord-018225-dozmy3lb 313 1 265 265 CD cord-018225-dozmy3lb 313 2 µmol µmol NNP cord-018225-dozmy3lb 313 3 / / SYM cord-018225-dozmy3lb 313 4 L l NN cord-018225-dozmy3lb 313 5 because because IN cord-018225-dozmy3lb 313 6 these these DT cord-018225-dozmy3lb 313 7 groups group NNS cord-018225-dozmy3lb 313 8 were be VBD cord-018225-dozmy3lb 313 9 excluded exclude VBN cord-018225-dozmy3lb 313 10 from from IN cord-018225-dozmy3lb 313 11 the the DT cord-018225-dozmy3lb 313 12 study study NN cord-018225-dozmy3lb 313 13 . . . cord-018225-dozmy3lb 314 1 This this DT cord-018225-dozmy3lb 314 2 is be VBZ cord-018225-dozmy3lb 314 3 a a DT cord-018225-dozmy3lb 314 4 well well RB cord-018225-dozmy3lb 314 5 - - HYPH cord-018225-dozmy3lb 314 6 designed design VBN cord-018225-dozmy3lb 314 7 , , , cord-018225-dozmy3lb 314 8 randomized randomize VBN cord-018225-dozmy3lb 314 9 , , , cord-018225-dozmy3lb 314 10 controlled control VBN cord-018225-dozmy3lb 314 11 trial trial NN cord-018225-dozmy3lb 314 12 from from IN cord-018225-dozmy3lb 314 13 the the DT cord-018225-dozmy3lb 314 14 group group NN cord-018225-dozmy3lb 314 15 who who WP cord-018225-dozmy3lb 314 16 virtually virtually RB cord-018225-dozmy3lb 314 17 singlehandedly singlehandedly RB cord-018225-dozmy3lb 314 18 have have VBP cord-018225-dozmy3lb 314 19 defined define VBN cord-018225-dozmy3lb 314 20 the the DT cord-018225-dozmy3lb 314 21 management management NN cord-018225-dozmy3lb 314 22 of of IN cord-018225-dozmy3lb 314 23 ascites ascites NN cord-018225-dozmy3lb 314 24 in in IN cord-018225-dozmy3lb 314 25 cirrhosis cirrhosis NN cord-018225-dozmy3lb 314 26 . . . cord-018225-dozmy3lb 315 1 There there EX cord-018225-dozmy3lb 315 2 are be VBP cord-018225-dozmy3lb 315 3 few few JJ cord-018225-dozmy3lb 315 4 . . . cord-018225-dozmy3lb 316 1 Further further JJ cord-018225-dozmy3lb 316 2 studies study NNS cord-018225-dozmy3lb 316 3 should should MD cord-018225-dozmy3lb 316 4 investigate investigate VB cord-018225-dozmy3lb 316 5 the the DT cord-018225-dozmy3lb 316 6 effect effect NN cord-018225-dozmy3lb 316 7 of of IN cord-018225-dozmy3lb 316 8 different different JJ cord-018225-dozmy3lb 316 9 doses dose NNS cord-018225-dozmy3lb 316 10 of of IN cord-018225-dozmy3lb 316 11 albumin albumin NN cord-018225-dozmy3lb 316 12 , , , cord-018225-dozmy3lb 316 13 and and CC cord-018225-dozmy3lb 316 14 whether whether IN cord-018225-dozmy3lb 316 15 other other JJ cord-018225-dozmy3lb 316 16 plasma plasma NN cord-018225-dozmy3lb 316 17 expanders expander NNS cord-018225-dozmy3lb 316 18 are be VBP cord-018225-dozmy3lb 316 19 equally equally RB cord-018225-dozmy3lb 316 20 effective effective JJ cord-018225-dozmy3lb 316 21 . . . cord-018225-dozmy3lb 317 1 This this DT cord-018225-dozmy3lb 317 2 study study NN cord-018225-dozmy3lb 317 3 does do VBZ cord-018225-dozmy3lb 317 4 not not RB cord-018225-dozmy3lb 317 5 specifically specifically RB cord-018225-dozmy3lb 317 6 involve involve VB cord-018225-dozmy3lb 317 7 patients patient NNS cord-018225-dozmy3lb 317 8 treated treat VBN cord-018225-dozmy3lb 317 9 in in IN cord-018225-dozmy3lb 317 10 an an DT cord-018225-dozmy3lb 317 11 intensive intensive JJ cord-018225-dozmy3lb 317 12 care care NN cord-018225-dozmy3lb 317 13 unit unit NN cord-018225-dozmy3lb 317 14 . . . cord-018225-dozmy3lb 318 1 Nevertheless nevertheless RB cord-018225-dozmy3lb 318 2 , , , cord-018225-dozmy3lb 318 3 spontaneous spontaneous JJ cord-018225-dozmy3lb 318 4 bacterial bacterial JJ cord-018225-dozmy3lb 318 5 peritonitis peritonitis NN cord-018225-dozmy3lb 318 6 is be VBZ cord-018225-dozmy3lb 318 7 responsible responsible JJ cord-018225-dozmy3lb 318 8 for for IN cord-018225-dozmy3lb 318 9 many many JJ cord-018225-dozmy3lb 318 10 admissions admission NNS cord-018225-dozmy3lb 318 11 of of IN cord-018225-dozmy3lb 318 12 cirrhotic cirrhotic JJ cord-018225-dozmy3lb 318 13 patients patient NNS cord-018225-dozmy3lb 318 14 to to IN cord-018225-dozmy3lb 318 15 the the DT cord-018225-dozmy3lb 318 16 ICU ICU NNP cord-018225-dozmy3lb 318 17 , , , cord-018225-dozmy3lb 318 18 as as IN cord-018225-dozmy3lb 318 19 it -PRON- PRP cord-018225-dozmy3lb 318 20 is be VBZ cord-018225-dozmy3lb 318 21 sometimes sometimes RB cord-018225-dozmy3lb 318 22 a a DT cord-018225-dozmy3lb 318 23 silent silent JJ cord-018225-dozmy3lb 318 24 precipitant precipitant NN cord-018225-dozmy3lb 318 25 of of IN cord-018225-dozmy3lb 318 26 gastrointestinal gastrointestinal JJ cord-018225-dozmy3lb 318 27 bleeding bleeding NN cord-018225-dozmy3lb 318 28 , , , cord-018225-dozmy3lb 318 29 encephalopathy encephalopathy NN cord-018225-dozmy3lb 318 30 , , , cord-018225-dozmy3lb 318 31 and and CC cord-018225-dozmy3lb 318 32 renal renal JJ cord-018225-dozmy3lb 318 33 impairment impairment NN cord-018225-dozmy3lb 318 34 , , , cord-018225-dozmy3lb 318 35 as as RB cord-018225-dozmy3lb 318 36 well well RB cord-018225-dozmy3lb 318 37 as as IN cord-018225-dozmy3lb 318 38 overt overt JJ cord-018225-dozmy3lb 318 39 sepsis sepsis NN cord-018225-dozmy3lb 318 40 . . . cord-018225-dozmy3lb 319 1 Indeed indeed RB cord-018225-dozmy3lb 319 2 , , , cord-018225-dozmy3lb 319 3 it -PRON- PRP cord-018225-dozmy3lb 319 4 should should MD cord-018225-dozmy3lb 319 5 be be VB cord-018225-dozmy3lb 319 6 excluded exclude VBN cord-018225-dozmy3lb 319 7 in in IN cord-018225-dozmy3lb 319 8 every every DT cord-018225-dozmy3lb 319 9 cirrhotic cirrhotic JJ cord-018225-dozmy3lb 319 10 patient patient NN cord-018225-dozmy3lb 319 11 admitted admit VBN cord-018225-dozmy3lb 319 12 to to IN cord-018225-dozmy3lb 319 13 the the DT cord-018225-dozmy3lb 319 14 ICU ICU NNP cord-018225-dozmy3lb 319 15 . . . cord-018225-dozmy3lb 320 1 Consequently consequently RB cord-018225-dozmy3lb 320 2 , , , cord-018225-dozmy3lb 320 3 advances advance NNS cord-018225-dozmy3lb 320 4 in in IN cord-018225-dozmy3lb 320 5 its -PRON- PRP$ cord-018225-dozmy3lb 320 6 treatment treatment NN cord-018225-dozmy3lb 320 7 are be VBP cord-018225-dozmy3lb 320 8 very very RB cord-018225-dozmy3lb 320 9 relevant relevant JJ cord-018225-dozmy3lb 320 10 to to IN cord-018225-dozmy3lb 320 11 the the DT cord-018225-dozmy3lb 320 12 ICU ICU NNP cord-018225-dozmy3lb 320 13 clinician clinician NN cord-018225-dozmy3lb 320 14 . . . cord-018225-dozmy3lb 321 1 Furthermore furthermore RB cord-018225-dozmy3lb 321 2 , , , cord-018225-dozmy3lb 321 3 despite despite IN cord-018225-dozmy3lb 321 4 the the DT cord-018225-dozmy3lb 321 5 current current JJ cord-018225-dozmy3lb 321 6 uncertainty uncertainty NN cord-018225-dozmy3lb 321 7 as as IN cord-018225-dozmy3lb 321 8 to to IN cord-018225-dozmy3lb 321 9 the the DT cord-018225-dozmy3lb 321 10 place place NN cord-018225-dozmy3lb 321 11 of of IN cord-018225-dozmy3lb 321 12 albumin albumin NN cord-018225-dozmy3lb 321 13 therapy therapy NN cord-018225-dozmy3lb 321 14 in in IN cord-018225-dozmy3lb 321 15 critically critically RB cord-018225-dozmy3lb 321 16 ill ill JJ cord-018225-dozmy3lb 321 17 patients patient NNS cord-018225-dozmy3lb 321 18 , , , cord-018225-dozmy3lb 321 19 it -PRON- PRP cord-018225-dozmy3lb 321 20 seems seem VBZ cord-018225-dozmy3lb 321 21 clear clear JJ cord-018225-dozmy3lb 321 22 that that IN cord-018225-dozmy3lb 321 23 it -PRON- PRP cord-018225-dozmy3lb 321 24 confers confer VBZ cord-018225-dozmy3lb 321 25 a a DT cord-018225-dozmy3lb 321 26 survival survival NN cord-018225-dozmy3lb 321 27 advantage advantage NN cord-018225-dozmy3lb 321 28 to to IN cord-018225-dozmy3lb 321 29 patients patient NNS cord-018225-dozmy3lb 321 30 with with IN cord-018225-dozmy3lb 321 31 cirrhosis cirrhosis NN cord-018225-dozmy3lb 321 32 and and CC cord-018225-dozmy3lb 321 33 spontaneous spontaneous JJ cord-018225-dozmy3lb 321 34 bacterial bacterial JJ cord-018225-dozmy3lb 321 35 peritonitis peritonitis NN cord-018225-dozmy3lb 321 36 . . .