id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323736-zup9cp6s	Ko, Sheung‐Fat	Hepatic (31)P‐magnetic resonance spectroscopy identified the impact of melatonin‐pretreated mitochondria in acute liver ischaemia‐reperfusion injury	2020-07-21		.txt	text/plain	4529	244	39	This study tested the hypothesis that (31)P‐magnetic resonance spectroscopy ((31)P‐MRS) findings could provide reliable living images to accurately identify the degree of acute liver IRI and melatonin‐pretreated mitochondria was an innovative treatment for protecting the liver from IRI in rat. [1] [2] [3] Studies have further displayed that several key factors contribute to the hepatic injury at the initiation and during the progression of liver IRI, including those of elevation of anaerobic metabolism, dysfunction of mitochondria, insult of oxidative stress, overload of intracellular calcium, activation of liver Kupffer cells, infiltration of immune cells and release of inflammatory cytokines. Additionally, this study further tested whether the 31 P-MRS examination could provide reliable living images to accurately identify the degree of ATP consumption/depletion in hepatocytes, that is an indicator of acute liver ischaemia-reperfusion in rodent. Melatonin-pretreated mitochondria effectively protected liver against IRI and 31 P-MRS was a reliable tool for measuring the mitochondrial/ATP consumption in living animals. Hepatic 31 P-magnetic resonance spectroscopy identified the impact of melatonin-pretreated mitochondria in acute liver ischaemia-reperfusion injury	./cache/cord-323736-zup9cp6s.txt	./txt/cord-323736-zup9cp6s.txt