Carrel name: keyword-level-cord Creating study carrel named keyword-level-cord Initializing database file: cache/cord-003520-f3jz59pt.json key: cord-003520-f3jz59pt authors: Arabi, Yaseen M.; Tamimi, Waleed; Jones, Gwynne; Jawdat, Dunia; Tamim, Hani; Al-Dorzi, Hasan M.; Sadat, Musharaf; Afesh, Lara; Sakhija, Maram; Al-Dawood, Abdulaziz title: Free Fatty Acids’ Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial date: 2019-02-13 journal: Nutrients DOI: 10.3390/nu11020384 sha: doc_id: 3520 cord_uid: f3jz59pt file: cache/cord-022070-soqeje4z.json key: cord-022070-soqeje4z authors: Parry, Christopher M.; Peacock, Sharon J. title: Microbiology date: 2019-05-28 journal: Hunter's Tropical Medicine and Emerging Infectious Diseases DOI: 10.1016/b978-0-323-55512-8.00021-1 sha: doc_id: 22070 cord_uid: soqeje4z file: cache/cord-016300-vw11c2wt.json key: cord-016300-vw11c2wt authors: Jain, Kewal K. title: Biomarkers of Pulmonary Diseases date: 2017-09-18 journal: The Handbook of Biomarkers DOI: 10.1007/978-1-4939-7431-3_16 sha: doc_id: 16300 cord_uid: vw11c2wt file: cache/cord-018414-6ffhm895.json key: cord-018414-6ffhm895 authors: Kang, Yoogoo; Elia, Elia title: Anesthesia Management of Liver Transplantation date: 2016-07-22 journal: Contemporary Liver Transplantation DOI: 10.1007/978-3-319-07209-8_9 sha: doc_id: 18414 cord_uid: 6ffhm895 file: cache/cord-011360-1n998win.json key: cord-011360-1n998win authors: Zloto, Keren; Tirosh-Wagner, Tal; Bolkier, Yoav; Bar-Yosef, Omer; Vardi, Amir; Mishali, David; Paret, Gidi; Nevo-Caspi, Yael title: Preoperative miRNA-208a as a Predictor of Postoperative Complications in Children with Congenital Heart Disease Undergoing Heart Surgery date: 2019-11-15 journal: J Cardiovasc Transl Res DOI: 10.1007/s12265-019-09921-1 sha: doc_id: 11360 cord_uid: 1n998win file: cache/cord-034746-uxhpufnv.json key: cord-034746-uxhpufnv authors: Nusshag, Christian; Stütz, Alisa; Hägele, Stefan; Speer, Claudius; Kälble, Florian; Eckert, Christoph; Brenner, Thorsten; Weigand, Markus A.; Morath, Christian; Reiser, Jochen; Zeier, Martin; Krautkrämer, Ellen title: Glomerular filtration barrier dysfunction in a self-limiting, RNA virus-induced glomerulopathy resembles findings in idiopathic nephrotic syndromes date: 2020-11-05 journal: Sci Rep DOI: 10.1038/s41598-020-76050-0 sha: doc_id: 34746 cord_uid: uxhpufnv file: cache/cord-015090-n6f4xupw.json key: cord-015090-n6f4xupw authors: nan title: PS 339-563 date: 2005-09-10 journal: Intensive Care Med DOI: 10.1007/s00134-005-2780-4 sha: doc_id: 15090 cord_uid: n6f4xupw file: cache/cord-018623-of9vx7og.json key: cord-018623-of9vx7og authors: Saghazadeh, Amene; Rezaei, Nima title: The Physical Burden of Immunoperception date: 2019-04-27 journal: Biophysics and Neurophysiology of the Sixth Sense DOI: 10.1007/978-3-030-10620-1_10 sha: doc_id: 18623 cord_uid: of9vx7og file: cache/cord-267237-wbwlfx7q.json key: cord-267237-wbwlfx7q authors: Gómez-Rial, Jose; Currás-Tuala, Maria José; Rivero-Calle, Irene; Gómez-Carballa, Alberto; Cebey-López, Miriam; Rodríguez-Tenreiro, Carmen; Dacosta-Urbieta, Ana; Rivero-Velasco, Carmen; Rodríguez-Núñez, Nuria; Trastoy-Pena, Rocio; Rodríguez-García, Javier; Salas, Antonio; Martinón-Torres, Federico title: Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology date: 2020-09-23 journal: Front Immunol DOI: 10.3389/fimmu.2020.560381 sha: doc_id: 267237 cord_uid: wbwlfx7q file: cache/cord-254646-psolkrom.json key: cord-254646-psolkrom authors: Matsui, Mary S. title: Vitamin D Update date: 2020-10-14 journal: Curr Dermatol Rep DOI: 10.1007/s13671-020-00315-0 sha: doc_id: 254646 cord_uid: psolkrom file: cache/cord-017309-pt27efu1.json key: cord-017309-pt27efu1 authors: Gupta, G. S. title: Selectins and Associated Adhesion Proteins in Inflammatory disorders date: 2012-03-20 journal: Animal Lectins: Form, Function and Clinical Applications DOI: 10.1007/978-3-7091-1065-2_44 sha: doc_id: 17309 cord_uid: pt27efu1 file: cache/cord-285151-zynor0b2.json key: cord-285151-zynor0b2 authors: Eisenhut, Michael title: Neopterin in Diagnosis and Monitoring of Infectious Diseases date: 2013-12-08 journal: J Biomark DOI: 10.1155/2013/196432 sha: doc_id: 285151 cord_uid: zynor0b2 file: cache/cord-284694-bk6bnox0.json key: cord-284694-bk6bnox0 authors: Wang, Changsong; Kang, Kai; Gao, Yan; Ye, Ming; Lan, Xiuwen; Li, Xueting; Zhao, Mingyan; Yu, Kaijiang title: Cytokine Levels in the Body Fluids of a Patient With COVID-19 and Acute Respiratory Distress Syndrome: A Case Report date: 2020-05-12 journal: Ann Intern Med DOI: 10.7326/l20-0354 sha: doc_id: 284694 cord_uid: bk6bnox0 file: cache/cord-352687-gncmygda.json key: cord-352687-gncmygda authors: Science, Michelle; Maguire, Jonathon L.; Russell, Margaret L.; Smieja, Marek; Walter, Stephen D.; Loeb, Mark title: Low Serum 25-Hydroxyvitamin D Level and Risk of Upper Respiratory Tract Infection in Children and Adolescents date: 2013-05-15 journal: Clinical Infectious Diseases DOI: 10.1093/cid/cit289 sha: doc_id: 352687 cord_uid: gncmygda file: cache/cord-121777-3zrnz9nc.json key: cord-121777-3zrnz9nc authors: Qian, Xuelin; Fu, Huazhu; Shi, Weiya; Chen, Tao; Fu, Yanwei; Shan, Fei; Xue, Xiangyang title: M3Lung-Sys: A Deep Learning System for Multi-Class Lung Pneumonia Screening from CT Imaging date: 2020-10-07 journal: nan DOI: nan sha: doc_id: 121777 cord_uid: 3zrnz9nc file: cache/cord-102738-e5zojanb.json key: cord-102738-e5zojanb authors: Lieberoth, Andreas; Pedersen, Mads Kock; Marin, Andreea Catalina; Planke, Tilo; Sherson, Jacob Friis title: Getting Humans to do Quantum Optimization - User Acquisition, Engagement and Early Results from the Citizen Cyberscience Game Quantum Moves date: 2015-06-26 journal: nan DOI: 10.15346/hc.v1i2.11 sha: doc_id: 102738 cord_uid: e5zojanb file: cache/cord-312418-e4g5u1nz.json key: cord-312418-e4g5u1nz authors: Melillo, Alessandro title: Rabbit Clinical Pathology date: 2007-09-18 journal: J Exot Pet Med DOI: 10.1053/j.jepm.2007.06.002 sha: doc_id: 312418 cord_uid: e4g5u1nz file: cache/cord-312580-r57rkrya.json key: cord-312580-r57rkrya authors: Harcourt-Brown, Frances title: Chapter 6 Clinical pathology date: 2002-12-31 journal: Textbook of Rabbit Medicine DOI: 10.1016/b978-075064002-2.50009-6 sha: doc_id: 312580 cord_uid: r57rkrya file: cache/cord-255575-640v00jg.json key: cord-255575-640v00jg authors: Binny, R. N.; Baker, M. G.; Hendy, S. C.; James, A.; Lustig, A.; Plank, M. J.; Ridings, K. M.; Steyn, N. title: Early intervention is the key to success in COVID-19 control date: 2020-10-23 journal: nan DOI: 10.1101/2020.10.20.20216457 sha: doc_id: 255575 cord_uid: 640v00jg file: cache/cord-015372-76xvzvdg.json key: cord-015372-76xvzvdg authors: nan title: National scientific medical meeting 1996 abstracts date: 1996 journal: Ir J Med Sci DOI: 10.1007/bf02945204 sha: doc_id: 15372 cord_uid: 76xvzvdg file: cache/cord-005633-oyhpwut7.json key: cord-005633-oyhpwut7 authors: Oppert, Michael; Reinicke, Albrecht; Gräf, Klaus-Jürgen; Barckow, Detlef; Frei, Ulrich; Eckardt, Kai-Uwe title: Plasma cortisol levels before and during "low-dose" hydrocortisone therapy and their relationship to hemodynamic improvement in patients with septic shock date: 2000-11-18 journal: Intensive Care Med DOI: 10.1007/s001340000685 sha: doc_id: 5633 cord_uid: oyhpwut7 file: cache/cord-022353-q2k2krnm.json key: cord-022353-q2k2krnm authors: W. Quimby, Fred; H. Luong, Richard title: Clinical Chemistry of the Laboratory Mouse date: 2007-09-02 journal: The Mouse in Biomedical Research DOI: 10.1016/b978-012369454-6/50060-1 sha: doc_id: 22353 cord_uid: q2k2krnm file: cache/cord-264427-frrq4h39.json key: cord-264427-frrq4h39 authors: Huang, Ling; Liu, Ziyi; Li, Hongli; Wang, Yangjun; Li, Yumin; Zhu, Yonghui; Ooi, Maggie Chel Gee; An, Jing; Shang, Yu; Zhang, Dongping; Chan, Andy; Li, Li title: The silver lining of COVID‐19: estimation of short‐term health impacts due to lockdown in the Yangtze River Delta region, China date: 2020-07-07 journal: Geohealth DOI: 10.1029/2020gh000272 sha: doc_id: 264427 cord_uid: frrq4h39 file: cache/cord-104157-rivaoo73.json key: cord-104157-rivaoo73 authors: Noreika, Valdas; Kamke, Marc R.; Canales-Johnson, Andrés; Chennu, Srivas; Bekinschtein, Tristan A.; Mattingley, Jason B. title: Alertness fluctuations during task performance modulate cortical evoked responses to transcranial magnetic stimulation date: 2019-06-28 journal: bioRxiv DOI: 10.1101/155754 sha: doc_id: 104157 cord_uid: rivaoo73 file: cache/cord-266034-811lov8f.json key: cord-266034-811lov8f authors: Benameur, Karima; Agarwal, Ankita; Auld, Sara C.; Butters, Matthew P.; Webster, Andrew S.; Ozturk, Tugba; Howell, J. Christina; Bassit, Leda C.; Velasquez, Alvaro; Schinazi, Raymond F.; Mullins, Mark E.; Hu, William T. title: Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020 date: 2020-09-17 journal: Emerg Infect Dis DOI: 10.3201/eid2609.202122 sha: doc_id: 266034 cord_uid: 811lov8f file: cache/cord-270184-bq5p2gs6.json key: cord-270184-bq5p2gs6 authors: Alrubaiee, Gamil Ghaleb; Al-Qalah, Talal Ali Hussein; Al-Aawar, Mohammed Sadeg A. title: Knowledge, attitudes, anxiety, and preventive behaviours towards COVID-19 among health care providers in Yemen: an online cross-sectional survey date: 2020-10-13 journal: BMC Public Health DOI: 10.1186/s12889-020-09644-y sha: doc_id: 270184 cord_uid: bq5p2gs6 file: cache/cord-149748-ucsxbzen.json key: cord-149748-ucsxbzen authors: Borowski, Elisa; Soria, Jason; Schofer, Joseph; Stathopoulos, Amanda title: Disparities in ridesourcing demand for mobility resilience: A multilevel analysis of neighborhood effects in Chicago, Illinois date: 2020-10-29 journal: nan DOI: nan sha: doc_id: 149748 cord_uid: ucsxbzen file: cache/cord-336201-fl606l3b.json key: cord-336201-fl606l3b authors: Daryabor, Gholamreza; Atashzar, Mohamad Reza; Kabelitz, Dieter; Meri, Seppo; Kalantar, Kurosh title: The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System date: 2020-07-22 journal: Front Immunol DOI: 10.3389/fimmu.2020.01582 sha: doc_id: 336201 cord_uid: fl606l3b file: cache/cord-035308-996ysogr.json key: cord-035308-996ysogr authors: Twining, Peter; Butler, Deirdre; Fisser, Petra; Leahy, Margaret; Shelton, Chris; Forget-Dubois, Nadine; Lacasse, Michel title: Developing a quality curriculum in a technological era date: 2020-11-11 journal: Educ Technol Res Dev DOI: 10.1007/s11423-020-09857-3 sha: doc_id: 35308 cord_uid: 996ysogr file: cache/cord-264749-m1awr1rm.json key: cord-264749-m1awr1rm authors: Saad, Julian M.; Prochaska, James O. title: A philosophy of health: life as reality, health as a universal value date: 2020-03-18 journal: Palgrave Commun DOI: 10.1057/s41599-020-0420-9 sha: doc_id: 264749 cord_uid: m1awr1rm file: cache/cord-349831-0u9y35qo.json key: cord-349831-0u9y35qo authors: Ellis, George F. R. title: The Causal Closure of Physics in Real World Contexts date: 2020-08-18 journal: Found Phys DOI: 10.1007/s10701-020-00366-0 sha: doc_id: 349831 cord_uid: 0u9y35qo file: cache/cord-252343-a85wz2hs.json key: cord-252343-a85wz2hs authors: Skoda, Eva-Maria; Teufel, Martin; Stang, Andreas; Jöckel, Karl-Heinz; Junne, Florian; Weismüller, Benjamin; Hetkamp, Madeleine; Musche, Venja; Kohler, Hannah; Dörrie, Nora; Schweda, Adam; Bäuerle, Alexander title: Psychological burden of healthcare professionals in Germany during the acute phase of the COVID-19 pandemic: differences and similarities in the international context date: 2020-08-07 journal: J Public Health (Oxf) DOI: 10.1093/pubmed/fdaa124 sha: doc_id: 252343 cord_uid: a85wz2hs file: cache/cord-006435-4o8uu6d5.json key: cord-006435-4o8uu6d5 authors: Kivity, Shaye; Katz, Uriel; Daniel, Natalie; Nussinovitch, Udi; Papageorgiou, Neophytos; Shoenfeld, Yehuda title: Evidence for the Use of Intravenous Immunoglobulins—A Review of the Literature date: 2009-07-10 journal: Clin Rev Allergy Immunol DOI: 10.1007/s12016-009-8155-9 sha: doc_id: 6435 cord_uid: 4o8uu6d5 file: cache/cord-015082-l629n8is.json key: cord-015082-l629n8is authors: nan title: Poster Sessions 323-461 date: 2002-08-29 journal: Intensive Care Med DOI: 10.1007/s00134-002-1455-7 sha: doc_id: 15082 cord_uid: l629n8is file: cache/cord-344656-xx76w7c0.json key: cord-344656-xx76w7c0 authors: Sarder, MD title: Logistics customer services date: 2020-10-16 journal: Logistics Transportation Systems DOI: 10.1016/b978-0-12-815974-3.00008-3 sha: doc_id: 344656 cord_uid: xx76w7c0 file: cache/cord-332432-q7u943k6.json key: cord-332432-q7u943k6 authors: Hofkirchner, Wolfgang title: A paradigm shift for the Great Bifurcation date: 2020-06-30 journal: Biosystems DOI: 10.1016/j.biosystems.2020.104193 sha: doc_id: 332432 cord_uid: q7u943k6 file: cache/cord-349581-o320ogmg.json key: cord-349581-o320ogmg authors: Robertson, Lindsay J. title: The technological 'exposure' of populations; characterisation and future reduction date: 2020-05-25 journal: Futures DOI: 10.1016/j.futures.2020.102584 sha: doc_id: 349581 cord_uid: o320ogmg file: cache/cord-296717-ay4wcmk3.json key: cord-296717-ay4wcmk3 authors: Long, Wen; Zhao, Manyi; Tang, Yeran title: Can the Chinese volatility index reflect investor sentiment? date: 2020-10-20 journal: nan DOI: 10.1016/j.irfa.2020.101612 sha: doc_id: 296717 cord_uid: ay4wcmk3 file: cache/cord-280040-xphxlaat.json key: cord-280040-xphxlaat authors: Rutala, William A.; Weber, David J. title: Disinfection and Sterilization in Health Care Facilities An Overview and Current Issues date: 2016-09-30 journal: Infectious Disease Clinics of North America DOI: 10.1016/j.idc.2016.04.002 sha: doc_id: 280040 cord_uid: xphxlaat file: cache/cord-006391-esnsa4u5.json key: cord-006391-esnsa4u5 authors: nan title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date: 1982 journal: Langenbecks Arch Chir DOI: 10.1007/bf01279099 sha: doc_id: 6391 cord_uid: esnsa4u5 file: cache/cord-004948-ad3i9wgj.json key: cord-004948-ad3i9wgj authors: nan title: 7th International Congress on Amino Acids and Proteins : Vienna, Austria, August 6–10, 2001 date: 2001 journal: Amino Acids DOI: 10.1007/s007260170030 sha: doc_id: 4948 cord_uid: ad3i9wgj file: cache/cord-015024-2xzc0uc5.json key: cord-015024-2xzc0uc5 authors: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 journal: Intensive Care Med DOI: 10.1007/s00134-010-2001-7 sha: doc_id: 15024 cord_uid: 2xzc0uc5 file: cache/cord-022653-qa1uph35.json key: cord-022653-qa1uph35 authors: nan title: Poster Discussion Session PDS date: 2017-08-30 journal: Allergy DOI: 10.1111/all.13251 sha: doc_id: 22653 cord_uid: qa1uph35 file: cache/cord-003532-lcgeingz.json key: cord-003532-lcgeingz authors: nan title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 journal: Crit Care DOI: 10.1186/s13054-019-2358-0 sha: doc_id: 3532 cord_uid: lcgeingz file: cache/cord-005646-xhx9pzhj.json key: cord-005646-xhx9pzhj authors: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 journal: Intensive Care Med DOI: 10.1007/bf02316512 sha: doc_id: 5646 cord_uid: xhx9pzhj file: cache/cord-004879-pgyzluwp.json key: cord-004879-pgyzluwp authors: nan title: Programmed cell death date: 1994 journal: Experientia DOI: 10.1007/bf02033112 sha: doc_id: 4879 cord_uid: pgyzluwp file: cache/cord-015147-h0o0yqv8.json key: cord-015147-h0o0yqv8 authors: nan title: Oral Communications and Posters date: 2014-09-12 journal: Inflamm Res DOI: 10.1007/bf03353884 sha: doc_id: 15147 cord_uid: h0o0yqv8 file: cache/cord-015306-us58wwmp.json key: cord-015306-us58wwmp authors: nan title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 journal: Pediatr Nephrol DOI: 10.1007/s00467-013-2518-4 sha: doc_id: 15306 cord_uid: us58wwmp file: cache/cord-006860-a3b8hyyr.json key: cord-006860-a3b8hyyr authors: nan title: 40th Annual Meeting of the GTH (Gesellschaft für Thrombose- und Hämostaseforschung) date: 1996 journal: Ann Hematol DOI: 10.1007/bf00641048 sha: doc_id: 6860 cord_uid: a3b8hyyr file: cache/cord-022633-fr55uod6.json key: cord-022633-fr55uod6 authors: nan title: SAEM Abstracts, Plenary Session date: 2012-04-26 journal: Acad Emerg Med DOI: 10.1111/j.1553-2712.2012.01332.x sha: doc_id: 22633 cord_uid: fr55uod6 file: cache/cord-022650-phsr10jp.json key: cord-022650-phsr10jp authors: nan title: Abstracts TPS date: 2018-08-14 journal: Allergy DOI: 10.1111/all.13539 sha: doc_id: 22650 cord_uid: phsr10jp file: cache/cord-006229-7yoilsho.json key: cord-006229-7yoilsho authors: nan title: Abstracts of the 82(nd) Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and the 18(th) Annual Meeting of the Network Clinical Pharmacology Germany (VKliPha) in cooperation with the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e.V. (AGAH) date: 2016-02-06 journal: Naunyn Schmiedebergs Arch Pharmacol DOI: 10.1007/s00210-016-1213-y sha: doc_id: 6229 cord_uid: 7yoilsho file: cache/cord-000083-3p81yr4n.json key: cord-000083-3p81yr4n authors: nan title: Poster Exhibition date: 2009-01-31 journal: Hepatol Int DOI: 10.1007/s12072-009-9123-4 sha: doc_id: 83 cord_uid: 3p81yr4n file: cache/cord-023157-0lqlx2rv.json key: cord-023157-0lqlx2rv authors: nan title: Poster Sessions date: 2013-04-18 journal: J Diabetes DOI: 10.1111/1753-0407.12032_1 sha: doc_id: 23157 cord_uid: 0lqlx2rv file: cache/cord-006230-xta38e7j.json key: cord-006230-xta38e7j authors: nan title: Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. date: 2012-02-22 journal: Naunyn Schmiedebergs Arch Pharmacol DOI: 10.1007/s00210-012-0736-0 sha: doc_id: 6230 cord_uid: xta38e7j file: cache/cord-015021-pol2qm74.json key: cord-015021-pol2qm74 authors: nan title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 journal: Intensive Care Med DOI: 10.1007/bf02258437 sha: doc_id: 15021 cord_uid: pol2qm74 file: cache/cord-005814-ak5pq312.json key: cord-005814-ak5pq312 authors: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 journal: Intensive Care Med DOI: 10.1007/bf02426401 sha: doc_id: 5814 cord_uid: ak5pq312 file: cache/cord-015394-uj7fe5y6.json key: cord-015394-uj7fe5y6 authors: nan title: Scientific Abstracts date: 2008-12-23 journal: Reprod Sci DOI: 10.1177/19337191080150020102 sha: doc_id: 15394 cord_uid: uj7fe5y6 file: cache/cord-022940-atbjwpo5.json key: cord-022940-atbjwpo5 authors: nan title: Poster Sessions date: 2016-09-07 journal: FEBS J DOI: 10.1111/febs.13808 sha: doc_id: 22940 cord_uid: atbjwpo5 Reading metadata file and updating bibliogrpahics === updating bibliographic database Building study carrel named keyword-level-cord === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 95885 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 97306 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 95661 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 816 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 97588 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 98295 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 98125 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 2323 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 3008 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 499 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 2661 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-284694-bk6bnox0 author: Wang, Changsong title: Cytokine Levels in the Body Fluids of a Patient With COVID-19 and Acute Respiratory Distress Syndrome: A Case Report date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-284694-bk6bnox0.txt cache: ./cache/cord-284694-bk6bnox0.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284694-bk6bnox0.txt' === file2bib.sh === id: cord-003520-f3jz59pt author: Arabi, Yaseen M. title: Free Fatty Acids’ Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial date: 2019-02-13 pages: extension: .txt txt: ./txt/cord-003520-f3jz59pt.txt cache: ./cache/cord-003520-f3jz59pt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-003520-f3jz59pt.txt' === file2bib.sh === id: cord-267237-wbwlfx7q author: Gómez-Rial, Jose title: Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology date: 2020-09-23 pages: extension: .txt txt: ./txt/cord-267237-wbwlfx7q.txt cache: ./cache/cord-267237-wbwlfx7q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-267237-wbwlfx7q.txt' === file2bib.sh === id: cord-022070-soqeje4z author: Parry, Christopher M. title: Microbiology date: 2019-05-28 pages: extension: .txt txt: ./txt/cord-022070-soqeje4z.txt cache: ./cache/cord-022070-soqeje4z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-022070-soqeje4z.txt' === file2bib.sh === id: cord-034746-uxhpufnv author: Nusshag, Christian title: Glomerular filtration barrier dysfunction in a self-limiting, RNA virus-induced glomerulopathy resembles findings in idiopathic nephrotic syndromes date: 2020-11-05 pages: extension: .txt txt: ./txt/cord-034746-uxhpufnv.txt cache: ./cache/cord-034746-uxhpufnv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-034746-uxhpufnv.txt' === file2bib.sh === id: cord-252343-a85wz2hs author: Skoda, Eva-Maria title: Psychological burden of healthcare professionals in Germany during the acute phase of the COVID-19 pandemic: differences and similarities in the international context date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-252343-a85wz2hs.txt cache: ./cache/cord-252343-a85wz2hs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-252343-a85wz2hs.txt' === file2bib.sh === id: cord-264427-frrq4h39 author: Huang, Ling title: The silver lining of COVID‐19: estimation of short‐term health impacts due to lockdown in the Yangtze River Delta region, China date: 2020-07-07 pages: extension: .txt txt: ./txt/cord-264427-frrq4h39.txt cache: ./cache/cord-264427-frrq4h39.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-264427-frrq4h39.txt' === file2bib.sh === id: cord-005633-oyhpwut7 author: Oppert, Michael title: Plasma cortisol levels before and during "low-dose" hydrocortisone therapy and their relationship to hemodynamic improvement in patients with septic shock date: 2000-11-18 pages: extension: .txt txt: ./txt/cord-005633-oyhpwut7.txt cache: ./cache/cord-005633-oyhpwut7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005633-oyhpwut7.txt' === file2bib.sh === id: cord-018623-of9vx7og author: Saghazadeh, Amene title: The Physical Burden of Immunoperception date: 2019-04-27 pages: extension: .txt txt: ./txt/cord-018623-of9vx7og.txt cache: ./cache/cord-018623-of9vx7og.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-018623-of9vx7og.txt' === file2bib.sh === id: cord-270184-bq5p2gs6 author: Alrubaiee, Gamil Ghaleb title: Knowledge, attitudes, anxiety, and preventive behaviours towards COVID-19 among health care providers in Yemen: an online cross-sectional survey date: 2020-10-13 pages: extension: .txt txt: ./txt/cord-270184-bq5p2gs6.txt cache: ./cache/cord-270184-bq5p2gs6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-270184-bq5p2gs6.txt' === file2bib.sh === id: cord-312418-e4g5u1nz author: Melillo, Alessandro title: Rabbit Clinical Pathology date: 2007-09-18 pages: extension: .txt txt: ./txt/cord-312418-e4g5u1nz.txt cache: ./cache/cord-312418-e4g5u1nz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312418-e4g5u1nz.txt' === file2bib.sh === id: cord-332432-q7u943k6 author: Hofkirchner, Wolfgang title: A paradigm shift for the Great Bifurcation date: 2020-06-30 pages: extension: .txt txt: ./txt/cord-332432-q7u943k6.txt cache: ./cache/cord-332432-q7u943k6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-332432-q7u943k6.txt' === file2bib.sh === id: cord-296717-ay4wcmk3 author: Long, Wen title: Can the Chinese volatility index reflect investor sentiment? date: 2020-10-20 pages: extension: .txt txt: ./txt/cord-296717-ay4wcmk3.txt cache: ./cache/cord-296717-ay4wcmk3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-296717-ay4wcmk3.txt' === file2bib.sh === id: cord-349581-o320ogmg author: Robertson, Lindsay J. title: The technological 'exposure' of populations; characterisation and future reduction date: 2020-05-25 pages: extension: .txt txt: ./txt/cord-349581-o320ogmg.txt cache: ./cache/cord-349581-o320ogmg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349581-o320ogmg.txt' === file2bib.sh === id: cord-149748-ucsxbzen author: Borowski, Elisa title: Disparities in ridesourcing demand for mobility resilience: A multilevel analysis of neighborhood effects in Chicago, Illinois date: 2020-10-29 pages: extension: .txt txt: ./txt/cord-149748-ucsxbzen.txt cache: ./cache/cord-149748-ucsxbzen.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-149748-ucsxbzen.txt' === file2bib.sh === id: cord-035308-996ysogr author: Twining, Peter title: Developing a quality curriculum in a technological era date: 2020-11-11 pages: extension: .txt txt: ./txt/cord-035308-996ysogr.txt cache: ./cache/cord-035308-996ysogr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-035308-996ysogr.txt' === file2bib.sh === id: cord-264749-m1awr1rm author: Saad, Julian M. title: A philosophy of health: life as reality, health as a universal value date: 2020-03-18 pages: extension: .txt txt: ./txt/cord-264749-m1awr1rm.txt cache: ./cache/cord-264749-m1awr1rm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-264749-m1awr1rm.txt' === file2bib.sh === id: cord-104157-rivaoo73 author: Noreika, Valdas title: Alertness fluctuations during task performance modulate cortical evoked responses to transcranial magnetic stimulation date: 2019-06-28 pages: extension: .txt txt: ./txt/cord-104157-rivaoo73.txt cache: ./cache/cord-104157-rivaoo73.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-104157-rivaoo73.txt' === file2bib.sh === id: cord-312580-r57rkrya author: Harcourt-Brown, Frances title: Chapter 6 Clinical pathology date: 2002-12-31 pages: extension: .txt txt: ./txt/cord-312580-r57rkrya.txt cache: ./cache/cord-312580-r57rkrya.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-312580-r57rkrya.txt' === file2bib.sh === id: cord-006435-4o8uu6d5 author: Kivity, Shaye title: Evidence for the Use of Intravenous Immunoglobulins—A Review of the Literature date: 2009-07-10 pages: extension: .txt txt: ./txt/cord-006435-4o8uu6d5.txt cache: ./cache/cord-006435-4o8uu6d5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006435-4o8uu6d5.txt' === file2bib.sh === id: cord-336201-fl606l3b author: Daryabor, Gholamreza title: The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System date: 2020-07-22 pages: extension: .txt txt: ./txt/cord-336201-fl606l3b.txt cache: ./cache/cord-336201-fl606l3b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-336201-fl606l3b.txt' === file2bib.sh === id: cord-349831-0u9y35qo author: Ellis, George F. R. title: The Causal Closure of Physics in Real World Contexts date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-349831-0u9y35qo.txt cache: ./cache/cord-349831-0u9y35qo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-349831-0u9y35qo.txt' === file2bib.sh === id: cord-018414-6ffhm895 author: Kang, Yoogoo title: Anesthesia Management of Liver Transplantation date: 2016-07-22 pages: extension: .txt txt: ./txt/cord-018414-6ffhm895.txt cache: ./cache/cord-018414-6ffhm895.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018414-6ffhm895.txt' === file2bib.sh === id: cord-015090-n6f4xupw author: nan title: PS 339-563 date: 2005-09-10 pages: extension: .txt txt: ./txt/cord-015090-n6f4xupw.txt cache: ./cache/cord-015090-n6f4xupw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-015090-n6f4xupw.txt' === file2bib.sh === id: cord-015082-l629n8is author: nan title: Poster Sessions 323-461 date: 2002-08-29 pages: extension: .txt txt: ./txt/cord-015082-l629n8is.txt cache: ./cache/cord-015082-l629n8is.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-015082-l629n8is.txt' === file2bib.sh === id: cord-017309-pt27efu1 author: Gupta, G. S. title: Selectins and Associated Adhesion Proteins in Inflammatory disorders date: 2012-03-20 pages: extension: .txt txt: ./txt/cord-017309-pt27efu1.txt cache: ./cache/cord-017309-pt27efu1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-017309-pt27efu1.txt' === file2bib.sh === id: cord-022353-q2k2krnm author: W. Quimby, Fred title: Clinical Chemistry of the Laboratory Mouse date: 2007-09-02 pages: extension: .txt txt: ./txt/cord-022353-q2k2krnm.txt cache: ./cache/cord-022353-q2k2krnm.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-022353-q2k2krnm.txt' === file2bib.sh === id: cord-015372-76xvzvdg author: nan title: National scientific medical meeting 1996 abstracts date: 1996 pages: extension: .txt txt: ./txt/cord-015372-76xvzvdg.txt cache: ./cache/cord-015372-76xvzvdg.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-015372-76xvzvdg.txt' === file2bib.sh === id: cord-006391-esnsa4u5 author: nan title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date: 1982 pages: extension: .txt txt: ./txt/cord-006391-esnsa4u5.txt cache: ./cache/cord-006391-esnsa4u5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-006391-esnsa4u5.txt' === file2bib.sh === id: cord-022653-qa1uph35 author: nan title: Poster Discussion Session PDS date: 2017-08-30 pages: extension: .txt txt: ./txt/cord-022653-qa1uph35.txt cache: ./cache/cord-022653-qa1uph35.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-022653-qa1uph35.txt' === file2bib.sh === id: cord-004948-ad3i9wgj author: nan title: 7th International Congress on Amino Acids and Proteins : Vienna, Austria, August 6–10, 2001 date: 2001 pages: extension: .txt txt: ./txt/cord-004948-ad3i9wgj.txt cache: ./cache/cord-004948-ad3i9wgj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-004948-ad3i9wgj.txt' === file2bib.sh === id: cord-005646-xhx9pzhj author: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 pages: extension: .txt txt: ./txt/cord-005646-xhx9pzhj.txt cache: ./cache/cord-005646-xhx9pzhj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-005646-xhx9pzhj.txt' === file2bib.sh === id: cord-015306-us58wwmp author: nan title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 pages: extension: .txt txt: ./txt/cord-015306-us58wwmp.txt cache: ./cache/cord-015306-us58wwmp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-015306-us58wwmp.txt' === file2bib.sh === id: cord-015147-h0o0yqv8 author: nan title: Oral Communications and Posters date: 2014-09-12 pages: extension: .txt txt: ./txt/cord-015147-h0o0yqv8.txt cache: ./cache/cord-015147-h0o0yqv8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-015147-h0o0yqv8.txt' === file2bib.sh === id: cord-004879-pgyzluwp author: nan title: Programmed cell death date: 1994 pages: extension: .txt txt: ./txt/cord-004879-pgyzluwp.txt cache: ./cache/cord-004879-pgyzluwp.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-004879-pgyzluwp.txt' === file2bib.sh === id: cord-003532-lcgeingz author: nan title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 pages: extension: .txt txt: ./txt/cord-003532-lcgeingz.txt cache: ./cache/cord-003532-lcgeingz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 19 resourceName b'cord-003532-lcgeingz.txt' === file2bib.sh === id: cord-015024-2xzc0uc5 author: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 pages: extension: .txt txt: ./txt/cord-015024-2xzc0uc5.txt cache: ./cache/cord-015024-2xzc0uc5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-015024-2xzc0uc5.txt' === file2bib.sh === id: cord-006860-a3b8hyyr author: nan title: 40th Annual Meeting of the GTH (Gesellschaft für Thrombose- und Hämostaseforschung) date: 1996 pages: extension: .txt txt: ./txt/cord-006860-a3b8hyyr.txt cache: ./cache/cord-006860-a3b8hyyr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-006860-a3b8hyyr.txt' === file2bib.sh === id: cord-022650-phsr10jp author: nan title: Abstracts TPS date: 2018-08-14 pages: extension: .txt txt: ./txt/cord-022650-phsr10jp.txt cache: ./cache/cord-022650-phsr10jp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-022650-phsr10jp.txt' === file2bib.sh === id: cord-000083-3p81yr4n author: nan title: Poster Exhibition date: 2009-01-31 pages: extension: .txt txt: ./txt/cord-000083-3p81yr4n.txt cache: ./cache/cord-000083-3p81yr4n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 31 resourceName b'cord-000083-3p81yr4n.txt' === file2bib.sh === id: cord-006229-7yoilsho author: nan title: Abstracts of the 82(nd) Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and the 18(th) Annual Meeting of the Network Clinical Pharmacology Germany (VKliPha) in cooperation with the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e.V. (AGAH) date: 2016-02-06 pages: extension: .txt txt: ./txt/cord-006229-7yoilsho.txt cache: ./cache/cord-006229-7yoilsho.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 13 resourceName b'cord-006229-7yoilsho.txt' === file2bib.sh === id: cord-006230-xta38e7j author: nan title: Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. date: 2012-02-22 pages: extension: .txt txt: ./txt/cord-006230-xta38e7j.txt cache: ./cache/cord-006230-xta38e7j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 14 resourceName b'cord-006230-xta38e7j.txt' === file2bib.sh === id: cord-023157-0lqlx2rv author: nan title: Poster Sessions date: 2013-04-18 pages: extension: .txt txt: ./txt/cord-023157-0lqlx2rv.txt cache: ./cache/cord-023157-0lqlx2rv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-023157-0lqlx2rv.txt' === file2bib.sh === id: cord-022633-fr55uod6 author: nan title: SAEM Abstracts, Plenary Session date: 2012-04-26 pages: extension: .txt txt: ./txt/cord-022633-fr55uod6.txt cache: ./cache/cord-022633-fr55uod6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-022633-fr55uod6.txt' === file2bib.sh === id: cord-015021-pol2qm74 author: nan title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 pages: extension: .txt txt: ./txt/cord-015021-pol2qm74.txt cache: ./cache/cord-015021-pol2qm74.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-015021-pol2qm74.txt' === file2bib.sh === id: cord-005814-ak5pq312 author: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 pages: extension: .txt txt: ./txt/cord-005814-ak5pq312.txt cache: ./cache/cord-005814-ak5pq312.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-005814-ak5pq312.txt' === file2bib.sh === id: cord-022940-atbjwpo5 author: nan title: Poster Sessions date: 2016-09-07 pages: extension: .txt txt: ./txt/cord-022940-atbjwpo5.txt cache: ./cache/cord-022940-atbjwpo5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 147 resourceName b'cord-022940-atbjwpo5.txt' === file2bib.sh === id: cord-015394-uj7fe5y6 author: nan title: Scientific Abstracts date: 2008-12-23 pages: extension: .txt txt: ./txt/cord-015394-uj7fe5y6.txt cache: ./cache/cord-015394-uj7fe5y6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 26 resourceName b'cord-015394-uj7fe5y6.txt' Que is empty; done keyword-level-cord === reduce.pl bib === id = cord-022070-soqeje4z author = Parry, Christopher M. title = Microbiology date = 2019-05-28 pages = extension = .txt mime = text/plain words = 3697 sentences = 185 flesch = 37 summary = Most of the world's population lacks access to accurate, affordable, easy-to-use, quality-assured, reliable, and accessible diagnostic tests and misdiagnosis of infectious diseases is common and compromises patient care. • Laboratories in resource-restricted settings struggle with poor facilities, lack of reliable water and electricity, inadequate equipment and consumables, insufficient staff, poor training and low morale, absence of standard operating procedures and quality assurance programs, and inadequate levels of biosafety. • Surveillance by microbiology laboratories provides an understanding of the causes of infection in the local population and the levels of antimicrobial resistance in key pathogens, and informs public health policy on appropriate antimicrobial therapy and preventive strategies. • There is increasing recognition of the need to support the development of a quality-assured laboratory service in resource-restricted settings and develop simple and robust point-of-care diagnostics both for routine clinical care and outbreak response. cache = ./cache/cord-022070-soqeje4z.txt txt = ./txt/cord-022070-soqeje4z.txt === reduce.pl bib === id = cord-003520-f3jz59pt author = Arabi, Yaseen M. title = Free Fatty Acids’ Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial date = 2019-02-13 pages = extension = .txt mime = text/plain words = 4280 sentences = 211 flesch = 51 summary = title: Free Fatty Acids' Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial Objectives: The objectives of this study were to evaluate the clinical and nutritional correlates of high free fatty acids (FFAs) level in critically ill patients and the association with outcomes, and to study the effect of short-term caloric restriction (permissive underfeeding) on FFAs level during critical illness. Conclusion: We conclude that high FFAs level in critically ill patients is associated with features of metabolic syndrome and is not affected by short-term permissive underfeeding. The aims of this study were (1) to evaluate the clinical and nutritional correlates of high FFAs level in critically ill patients and the association with outcomes, and (2) study the effect of short-term caloric restriction (permissive underfeeding) on FFAs level during critical illness. cache = ./cache/cord-003520-f3jz59pt.txt txt = ./txt/cord-003520-f3jz59pt.txt === reduce.pl bib === === reduce.pl bib === id = cord-018414-6ffhm895 author = Kang, Yoogoo title = Anesthesia Management of Liver Transplantation date = 2016-07-22 pages = extension = .txt mime = text/plain words = 21155 sentences = 1064 flesch = 34 summary = Specifically, patients with fulminant hepatic failure develop significant changes in cerebral function, and cerebral perfusion is maintained by monitoring cerebral blood flow and cerebral metabolic rate of oxygen, and intracranial pressure. Small-for-size syndrome develops in a patient who received a donor graft that was less than 1 % of the recipient's body weight and is caused by decreased hepatic arterial flow in response to increased portal venous flow and pressure. The major criteria for the diagnosis of the hepatorenal syndrome are as follows: (1) advanced hepatic disease and portal hypertension; (2) low glomerular filtration rate (serum creatinine >1.5 mg/dL or creatinine clearance <40 mL/ min); (3) absence of nephrotoxic drug use, shock, systemic infection, or recent fluid losses; (4) lack of sustained improvement after diuretic withdrawal and volume resuscitation with 1.5 L of normal saline; (5) proteinuria (<500 mg/dL); and (6) no ultrasound evidence of urinary obstruction or parenchymal disease. cache = ./cache/cord-018414-6ffhm895.txt txt = ./txt/cord-018414-6ffhm895.txt === reduce.pl bib === === reduce.pl bib === id = cord-034746-uxhpufnv author = Nusshag, Christian title = Glomerular filtration barrier dysfunction in a self-limiting, RNA virus-induced glomerulopathy resembles findings in idiopathic nephrotic syndromes date = 2020-11-05 pages = extension = .txt mime = text/plain words = 3642 sentences = 194 flesch = 36 summary = We therefore analyzed standard markers of glomerular proteinuria (e.g. immunoglobulin G [IgG]), urinary nephrin excretion (podocyte injury) and serum levels of the soluble urokinase plasminogen activator receptor (suPAR), a proposed pathomechanically involved molecule in INS, in PUUV-infected patients. On admission, patients suffering from hantavirus infection showed significantly increased urinary nephrin, IgG, α1-MG and serum suPAR levels compared to healthy controls (Fig. 3A ). Though, urinary biomarker levels decreased in both groups over time, patients with severe PCR showed significantly higher levels of nephrin, IgG, ACR and PCR during the first 48 h after admission ( Table 2 ). Our data show a strong association between urinary nephrin levels and the extent of (non-selective) glomerular proteinuria, suggesting that hantavirus infection causes a pronounced podocyte damage and subsequent impairment of the GFB. To date, one other study showed significantly elevated blood suPAR levels and their association with hantavirus disease severity but did not include nephrinuria and the extent of proteinuria in their analysis 19 . cache = ./cache/cord-034746-uxhpufnv.txt txt = ./txt/cord-034746-uxhpufnv.txt === reduce.pl bib === id = cord-015090-n6f4xupw author = nan title = PS 339-563 date = 2005-09-10 pages = extension = .txt mime = text/plain words = 26280 sentences = 1560 flesch = 53 summary = We designed this study to examine the effects of fiberoptic bronchoscopy (FOB) with and without BAL on body temperature, systemic arterial pressure, heart rate and supportive therapies requirements in mechanically ventilated patients. Clinical characteristics (Glasgow scale, heart rate, systolic blood pressure), cardiac enzymes (troponin I, total serum creatine kinase and myocardial isoenzyme, myoglobin), ECG changes (ST-T changes, prolonged QT and corrected QT intervals), echocardiographic assessment of cardiac function (left ventricular ejection fraction, hypokinesia) were studied on the day of the admission. It is a prospective study performed during 12 months of the patients with brain trauma admitted in a 24-beds medical-surgical ICU of a 650-beds university hospital. This prospective observational study included 200 adult patients admitted to a 31-bed university hospital medical-surgical ICU during a 3-month period. cache = ./cache/cord-015090-n6f4xupw.txt txt = ./txt/cord-015090-n6f4xupw.txt === reduce.pl bib === id = cord-018623-of9vx7og author = Saghazadeh, Amene title = The Physical Burden of Immunoperception date = 2019-04-27 pages = extension = .txt mime = text/plain words = 5755 sentences = 262 flesch = 37 summary = Further, human studies provided evidence pointing to the increased development of emotional problems and EDR-related disorders in patients with various types of AIDs, such as SLE and multiple sclerosis (MS), in a disease state/severity-dependent manner [12] [13] [14] [15] [16] [17] . Thus, it is not surprising that the inflammatory response and respective cytokines are supposed as one of the possible mechanisms linking the experience of negative emotions or ER-related disorders and the progression of cardiovascular diseases, of course along with the neuroendocrine system and apoptosis signaling pathways [27, 30, [32] [33] [34] [35] . Mice subjected to short-term (1-3 weeks) HFD also exhibited anxiety-like behaviors in addition to learning and memory impairments and had significantly higher levels of homovanillic acid-a metabolite of dopamine-in their hippocampus and cortex but without any alteration in the gene expression of inflammatory markers [89] . Increased emotional distress in daughters of breast cancer patients is associated with decreased natural cytotoxic activity, elevated levels of stress hormones and decreased secretion of Th1 cytokines cache = ./cache/cord-018623-of9vx7og.txt txt = ./txt/cord-018623-of9vx7og.txt === reduce.pl bib === id = cord-267237-wbwlfx7q author = Gómez-Rial, Jose title = Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology date = 2020-09-23 pages = extension = .txt mime = text/plain words = 2589 sentences = 148 flesch = 40 summary = METHODS: Fifty-nine SARS-Cov-2 positive hospitalized patients, classified according to ICU or non-ICU admission requirement, were prospectively recruited and analyzed by ELISA for levels of sCD14 and sCD163, along with other laboratory parameters, and compared to a healthy control group. CONCLUSIONS: Monocyte-macrophage activation markers are increased and correlate with other inflammatory markers in SARS-Cov-2 infection, in association to hospital admission. In this paper, we analyze serum levels of soluble monocyte activation markers in COVID-19 patients and their correlation with severity and other inflammatory markers. We found significant correlations between sCD14 and sCD163 levels and several clinical laboratory parameters in infected patients (in these analysis, adjusted significance under Bonferrori correction is 0.01), but only in the non-ICU group, possibly reflecting an interference of the use of tocilizumab or corticoids in the ICU group. Our results thus suggest that monocyte-macrophage activation can act as driver cells of the cytokine storm and immunopathology associated to severe clinical course of COVID-19 patients. cache = ./cache/cord-267237-wbwlfx7q.txt txt = ./txt/cord-267237-wbwlfx7q.txt === reduce.pl bib === id = cord-017309-pt27efu1 author = Gupta, G. S. title = Selectins and Associated Adhesion Proteins in Inflammatory disorders date = 2012-03-20 pages = extension = .txt mime = text/plain words = 25423 sentences = 1303 flesch = 40 summary = Activation of endothelial cells (EC) with different stimuli induces the expression of E-and P-selectins, and other adhesion molecules (ICAM-1, VCAM-1), involved in their interaction with circulating cells. Accordingly, population studies have explored the association of ischaemic heart disease with gene polymorphisms of the inflammatory molecules: tumor necrosis factors (TNF) a and b, transforming growth factors (TGF) b1 and 2, P and E selectins, and platelet endothelial cell adhesion molecule (PECAM) 1. Endothelial dysfunction in type 2 diabetic patients is associated with inflammation, increased levels of circulating soluble adhesion molecules (VCAM-1 and E-selectin), and inducing production of ROS, and urinary albumin excretion (Potenza et al. The A 561 C polymorphism of E-selectin gene may be associated with disease progression in patients with chronic HBV infection and control the expression of plasma soluble levels, while the G 98 T polymorphism may be related to fibrotic severity in Chinese population (Wu et al. cache = ./cache/cord-017309-pt27efu1.txt txt = ./txt/cord-017309-pt27efu1.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-284694-bk6bnox0 author = Wang, Changsong title = Cytokine Levels in the Body Fluids of a Patient With COVID-19 and Acute Respiratory Distress Syndrome: A Case Report date = 2020-05-12 pages = extension = .txt mime = text/plain words = 559 sentences = 28 flesch = 46 summary = title: Cytokine Levels in the Body Fluids of a Patient With COVID-19 and Acute Respiratory Distress Syndrome: A Case Report In addition, the time from symptom onset to confirmation of COVID-19 diagnosis was relatively long, the patient's hospital course was longer, and we wonder whether this long duration of viral replication contributed to the high cytokine levels we measured. As a result, we wonder whether tocilizumab would have affected the IL-6 levels we observed and whether it might have improved this patient's disease course, especially because others have reported that as COVID-19 progresses to its middle and late stages, the expression of inflammatory cytokines is related to the severity of the disease (4). On the basis of our experience, we encourage additional research to determine whether inflammatory cytokines in the lungs predict the clinical course of COVID-19 and whether these cytokines should be a target for intervention and treatment. cache = ./cache/cord-284694-bk6bnox0.txt txt = ./txt/cord-284694-bk6bnox0.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-312418-e4g5u1nz author = Melillo, Alessandro title = Rabbit Clinical Pathology date = 2007-09-18 pages = extension = .txt mime = text/plain words = 6442 sentences = 363 flesch = 46 summary = There is little information available that describes the effect of clinical disease on the blood parameters of companion rabbits, or on the use of blood tests as diagnostic and prognostic indicators. An intestinal isoenzyme is quite abundant, so serum ALP concentrations are actually the sum of these 3 isoenzymes, which may explain why many reference ranges are vague and wide and why raised ALP levels in clinically healthy animals are a common finding. Azotemia is also indicative of renal disease, usually affecting the rabbit patient in association with hyperkalemia or hypokalemia, hypercalcemia and coexisting hyperphosphatemia, nonregenerative anemia, and isostenuric urine. Blood urea levels below the reference range indicate hepatic insufficiency or muscle mass loss (e.g., dental disease). Hyperphosphatemia usually indicates chronic kidney failure (a loss of more than 80% of nephrons) given that serum phosphorus levels are normalized by compensatory mechanisms in early-onset renal disease. cache = ./cache/cord-312418-e4g5u1nz.txt txt = ./txt/cord-312418-e4g5u1nz.txt === reduce.pl bib === id = cord-312580-r57rkrya author = Harcourt-Brown, Frances title = Chapter 6 Clinical pathology date = 2002-12-31 pages = extension = .txt mime = text/plain words = 12627 sentences = 822 flesch = 51 summary = (1982) analysed the haematolog-• Rabbit blood clots quickly and haemolyses easily • Food deprivation does not guarantee a fasting blood sample as rabbits ingest caecotrophs • Stress associated with transport or handling can affect parameters such as blood glucose and the distribution of neutrophils and lymphocytes • Pregnancy, anaesthesia, blood collection techniques and intravenous fluid therapy will influence some blood results • Time of day can influence blood results as many parameters follow a duirnal rhythm in common with many physiological processes in rabbits • Laboratory reference ranges are often derived from animals of the same breed and strain. In two studies by Krueger (1988, 1989) controlled experimental infections with Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Candida albicans resulted in fever, increased plasma cortisol concentrations, neutrophilia and lymphopaenia but no significant increase in total white blood cell count. cache = ./cache/cord-312580-r57rkrya.txt txt = ./txt/cord-312580-r57rkrya.txt === reduce.pl bib === id = cord-015372-76xvzvdg author = nan title = National scientific medical meeting 1996 abstracts date = 1996 pages = extension = .txt mime = text/plain words = 36596 sentences = 2204 flesch = 53 summary = One, two and five-year survival rates were examined; age at diagnosis and lesion type were extremely significant factors in relation to patient outcome. Patients' age, sex, risk group, CDC stage, CD4 count, indication for therapy, complication rate and response to treatment are described. Fifty-eight patients (34 male, 24 female) ranging in age from 15 to 65 years (Mean + SD = 28.4 + 10.8) were included in the study. Among these 48 patients (mean age 68.0+12.7), after controlling for age and for the duration and continuity of subsequent antipsychotic treatment, increasing duration of initially untreated psychosis was associated with greater severity of negative symptoms (p<0.005) and with lower scores on the MMSE (p<0.05) but not with executive dysfunction on the EXIT (p=0.3). Conclusion Although not a population based study, care of IDDM in Ireland is almost totally hospital clinic based Cigarette smoking is identified as the major problem to be addressed Patients with diabetes meltitus (DM) are at a higher risk of developing vascular complications, including coronary artery disease (CAD). cache = ./cache/cord-015372-76xvzvdg.txt txt = ./txt/cord-015372-76xvzvdg.txt === reduce.pl bib === === reduce.pl bib === id = cord-005633-oyhpwut7 author = Oppert, Michael title = Plasma cortisol levels before and during "low-dose" hydrocortisone therapy and their relationship to hemodynamic improvement in patients with septic shock date = 2000-11-18 pages = extension = .txt mime = text/plain words = 3935 sentences = 190 flesch = 49 summary = Objectives: To compare cortisol levels during "low-dose" hydrocortisone therapy to basal and ACTH-stimulated endogenous levels and to assess whether clinical course and the need for catecholamines depend on cortisol levels and/or pretreatment adrenocortical responsiveness. Abstract Objectives: To compare cortisol levels during ªlow-doseº hydrocortisone therapy to basal and ACTH-stimulated endogenous levels and to assess whether clinical course and the need for catecholamines depend on cortisol levels and/or pretreatment adrenocortical responsiveness. Patients with ªinadequateº steroid production could be weaned from vasopressor therapy significantly faster, although their plasma free cortisol concentrations during the hydrocortisone treatment period did not differ. In contrast, two open studies [18, 19] and two recent randomized controlled trials [20, 21] have shown ªlowdoseº steroid therapy to have beneficial effects on hemodynamics and outcome in patients with septic shock, using no more than 300 mg hydrocortisone daily administered either as bolus injections of 100 mg three times daily or as continuous infusion. cache = ./cache/cord-005633-oyhpwut7.txt txt = ./txt/cord-005633-oyhpwut7.txt === reduce.pl bib === id = cord-022353-q2k2krnm author = W. Quimby, Fred title = Clinical Chemistry of the Laboratory Mouse date = 2007-09-02 pages = extension = .txt mime = text/plain words = 30195 sentences = 1702 flesch = 48 summary = Assessment of long-term average blood glucose levels in mice is also available by RIAs measuring glycosylated hemoglobin and glycosylated serum proteins (collectively known as fructosamines) (Gould et al. Leptin resistance, a common feature of obesity in mice and humans, has also been shown to result, in part, from the shedding of membrane-bound hepatic leptin receptors into the plasma, where soluble receptors modulate circulating leptin levels and possibly its biologic activity (Cohen et al. d. OTHER ANALYTES ASSOCIATED WITH LIPID METABOLISM AND ATHEROSCLEROSIS IN MICE ELISA kits are commercially available for the quantitation of many mouse coagulation proteins including: fibrinogen, factor VII, d-dimer, tissue factor, and von Willebrand's factor antigen. The ability of the first component of complement, C1, to bind specific sites on the heavy chain of mouse IgG2b and activate a sequence of reactions leading to production of a molecular unit capable of lysing a target cell membrane has established the complement system as the primary mediator of antibody-antigen reactions. cache = ./cache/cord-022353-q2k2krnm.txt txt = ./txt/cord-022353-q2k2krnm.txt === reduce.pl bib === id = cord-264427-frrq4h39 author = Huang, Ling title = The silver lining of COVID‐19: estimation of short‐term health impacts due to lockdown in the Yangtze River Delta region, China date = 2020-07-07 pages = extension = .txt mime = text/plain words = 3643 sentences = 174 flesch = 51 summary = According to our calculation, total number of avoided premature death associated PM(2.5) reduction during the lockdown is estimated to be 42.4 thousand over the YRD region, with Shanghai, Wenzhou, Suzhou (Jiangsu province), Nanjing, and Nantong being the top five cities with largest health benefits. Utilizing simulated results based on an integrated meteorology and air quality modeling system, we estimate the number of avoided premature death due to lowered PM2.5 concentrations during COVID-19 lockdown over the YRD region. We calculate the premature mortality due to above-mentioned causes based on the health impact function (Eq. 1) over the YRD region during pre-lockdown, Level I, and Level II period of 2017-2020 (Fig. 4) . In this study, we attempt to quantify the health impacts associated PM2.5 improvement due to reduced human and industrial activities during COVID-19 lockdown in the Yangtze River Delta region, a region with heavy air pollution during the past years. cache = ./cache/cord-264427-frrq4h39.txt txt = ./txt/cord-264427-frrq4h39.txt === reduce.pl bib === === reduce.pl bib === id = cord-104157-rivaoo73 author = Noreika, Valdas title = Alertness fluctuations during task performance modulate cortical evoked responses to transcranial magnetic stimulation date = 2019-06-28 pages = extension = .txt mime = text/plain words = 10469 sentences = 492 flesch = 52 summary = We observed rapid, non-linear changes in TMS-evoked neural responses – specifically, motor evoked potentials and TMS-evoked cortical potentials – as EEG activity indicated decreasing levels of alertness, even while participants remained awake and responsive in the behavioural task. Here we combined single-pulse TMS with concurrent EEG recording and a simple behavioural task to quantify changes in motor and cortical reactivity with fluctuating levels of alertness defined objectively on the basis of ongoing brain activity. To assess the instantaneous level of alertness, a two-fold EEG analysis was applied over the time window immediately preceding each TMS pulse: (1) a binary definition of awake and drowsy states following EEG spectral power signatures (θ/α) averaged across all EEG electrodes (Bareham et al., 2014) , and (2) a dynamical definition of alertness levels following a detailed sub-staging system for scoring the transition to N1 sleep (Hori et al., 1994) (Fig. 1C ). cache = ./cache/cord-104157-rivaoo73.txt txt = ./txt/cord-104157-rivaoo73.txt === reduce.pl bib === id = cord-149748-ucsxbzen author = Borowski, Elisa title = Disparities in ridesourcing demand for mobility resilience: A multilevel analysis of neighborhood effects in Chicago, Illinois date = 2020-10-29 pages = extension = .txt mime = text/plain words = 8850 sentences = 381 flesch = 44 summary = Applying a natural experiment approach to newly released ridesourcing data, we examine variation in the gap-filling role of on-demand mobility during sudden shocks to a transportation system by analyzing the change in use of ridesourcing during unexpected rail transit service disruptions across the racially and economically diverse city of Chicago. The main contributions of this study are the insights it provides into: (1) whether ridesourcing is used as a gap-filling transportation mode during transit disruptions in Chicago, (2) whether its utilization for this purpose is distributed equitably across the city in terms of racial and economic circumstances, and (3) whether variation in ridesourcing demand during disruptions is attributable to station-level, community-level, or quadrant-level contexts. We use a multilevel regression analysis to identify the station level, community area level, and city quadrant level factors associated with systematic variations in ridesourcing demand during transit disruptions. cache = ./cache/cord-149748-ucsxbzen.txt txt = ./txt/cord-149748-ucsxbzen.txt === reduce.pl bib === id = cord-270184-bq5p2gs6 author = Alrubaiee, Gamil Ghaleb title = Knowledge, attitudes, anxiety, and preventive behaviours towards COVID-19 among health care providers in Yemen: an online cross-sectional survey date = 2020-10-13 pages = extension = .txt mime = text/plain words = 5559 sentences = 271 flesch = 50 summary = METHODS: A descriptive, web-based-cross-sectional study was conducted among 1231 Yemeni HCPs. The COVID-19 related questionnaire was designed using Google forms where the responses were coded and analysed using the Statistical Package for the Social Sciences software package (IBM SPSS), version 22.0. The results further revealed that the majority of respondents had adequate knowledge, optimistic attitude, moderate level of anxiety, and high-performance in preventive behaviours, 69.8, 85.10%, 51.0 and 87.70%, respectively, towards COVID-19. The questionnaire consisted of 58 items that sought to collect information on the respondents' knowledge, attitude, anxiety, and preventive behaviours toward COVID-19. This fact motivated the need to undertake the current study aiming to explore the level of knowledge, attitude, anxiety, and preventive behaviours among HCPs towards the outbreak of COVID-19 in the country. cache = ./cache/cord-270184-bq5p2gs6.txt txt = ./txt/cord-270184-bq5p2gs6.txt === reduce.pl bib === id = cord-336201-fl606l3b author = Daryabor, Gholamreza title = The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System date = 2020-07-22 pages = extension = .txt mime = text/plain words = 13863 sentences = 715 flesch = 38 summary = Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues and finally, insulin resistance, organ failure, and premature aging occur. T2DM, the most common form of diabetes (∼90%), is characterized by a systemic inflammatory disease accompanied by insulin resistance (IR) or decreased metabolic response to insulin in several tissues, including the adipose tissue, liver, and skeletal muscle, as well as by reduced insulin synthesis by pancreatic beta cells (4, 5) . During the progression of diabetes, hyperglycemia promotes mitochondrial dysfunction and induces the formation of reactive oxygen species (ROS) that cause oxidative stress in several tissues such as blood vessels and pancreatic beta cells (7) (8) (9) . In addition, the attachment of AGEs to their receptors [e.g., CD36, galectin-3, scavenger receptors types I (SR-A1), and II (SR-A2)] on the surfaces of immune cells in the circulation and tissues activates the expression of pro-inflammatory cytokines and increases free radical generation (18) . cache = ./cache/cord-336201-fl606l3b.txt txt = ./txt/cord-336201-fl606l3b.txt === reduce.pl bib === id = cord-264749-m1awr1rm author = Saad, Julian M. title = A philosophy of health: life as reality, health as a universal value date = 2020-03-18 pages = extension = .txt mime = text/plain words = 9761 sentences = 475 flesch = 40 summary = The biological immune system, an individual's system of health behaviors, and the social system will be observed as systems that generate maintainable-ease of functioning in cells, selves, and societies respectively (Fig. 2 ). To observe health at the level of the cell, the self, and the society simultaneously, we consider systems that support maintainable-ease of biological, behavioral, and social functioning. Through this philosophy, one can go beyond biological systems to observe how precision (in the form of hostdefense functions, decision-making/executive functions, and values) and variation (in the form of microbiota functions, habits/habitual life functions, and population-wide behaviors) integrate to generate to maintainable-ease of functioning in cells, selves, and societies simultaneously (Fig. 3) . Similarly, when behavioral and social exposures are not tailored to the needs of individuals and groups, populations can become resistant to healthy change, and health is no longer valued at the level of the self and the society. cache = ./cache/cord-264749-m1awr1rm.txt txt = ./txt/cord-264749-m1awr1rm.txt === reduce.pl bib === id = cord-006435-4o8uu6d5 author = Kivity, Shaye title = Evidence for the Use of Intravenous Immunoglobulins—A Review of the Literature date = 2009-07-10 pages = extension = .txt mime = text/plain words = 14141 sentences = 874 flesch = 36 summary = Although convincing evidence is lacking for the use of IVIg in view of the severity and the refractory nature of several cases of Evans' syndrome, IVIg may be considered among the treatment options generally together with CS with or without immunosuppressive therapy (strength of recommendation IIb). Level of evidence B Evidence comes only from one crossover randomized placebo-controlled trial which supports the use of IVIg in HIV-associated thrombocytopenia, especially when platelet count is very low or the risk of bleeding is high (strength of recommendation IIa). Level of evidence B IVIg is not used for the treatment of CMV infection but may be helpful in treatment of hemophagocytic syndrome related to CMV and other viruses (see hematology section); there is some evidence for its effectiveness in preventing seroconversion in transplant patients who are immunosuppressed (strength of recommendation IIa). cache = ./cache/cord-006435-4o8uu6d5.txt txt = ./txt/cord-006435-4o8uu6d5.txt === reduce.pl bib === id = cord-349831-0u9y35qo author = Ellis, George F. R. title = The Causal Closure of Physics in Real World Contexts date = 2020-08-18 pages = extension = .txt mime = text/plain words = 15740 sentences = 965 flesch = 60 summary = Secondly, I show that causal closure in the hierarchy of emergence is a strictly interlevel affair, and in the cases of engineering and biology encompasses all levels from the social level to the particle physics level. In particular, the particle physics level is not causally complete by itself in the contexts of solid state physics (because of interlevel wave–particle duality), digital computers (where algorithms determine outcomes), or biology (because of time dependent constraints). Here I want to examine the issue in a different way, by dealing in some detail with the hierarchical nature of emergence in real world contexts: the cases of engineering, based in the underlying solid state physics, and biology, based in the underlying molecular biology, in turn based in the underlying physics. Effective Causal Closure in real world contexts spans many levels, in the case of biology reaching down from the level of the organism to the underlying physics via time dependent constraints. cache = ./cache/cord-349831-0u9y35qo.txt txt = ./txt/cord-349831-0u9y35qo.txt === reduce.pl bib === id = cord-015082-l629n8is author = nan title = Poster Sessions 323-461 date = 2002-08-29 pages = extension = .txt mime = text/plain words = 26569 sentences = 1648 flesch = 52 summary = 14 patients awaiting urgent cardiac surgical re-vascularisation were studied with measurement of: spirometry; percentage increase in transfer factor from sitting to lying position (TF) as an indicator of micro-vascular lung disease; overnight oximetry on air; and 24hour holter monitoring Patients, who were reintubated on decreased indices of arterial oxygenation under MOSF progressing died in 100% cases ( NIMV is effective method in complex therapy of ARF, developing in postoperative period after cardiac surgery, that leads to significant improvement of lungs biomechanics and gases change function. In a prospective observational study we performed bedside ptO2 measurements in 8 patients with sepsis/septic shock to gain insight in ptO2 values and their dynamic changes related to the course of the illness, as well as investigating the practical applicability of tissue oxygen measurement in the ICU setting. cache = ./cache/cord-015082-l629n8is.txt txt = ./txt/cord-015082-l629n8is.txt === reduce.pl bib === id = cord-349581-o320ogmg author = Robertson, Lindsay J. title = The technological 'exposure' of populations; characterisation and future reduction date = 2020-05-25 pages = extension = .txt mime = text/plain words = 9151 sentences = 424 flesch = 41 summary = The analysis of population exposure of a broad spectrum of needs showed that it was possible to identify some high exposure technological fields, specifically complex components, complex artificial substances, finance, communications, energy and information, These are considered more fully as follows; Although the feasibility of internet communications can be attributed to open source protocols, the practicality of current connectivity has been J o u r n a l P r e -p r o o f largely enabled by the very large data rates possible via fibre-optic cables, yet this capacity has also introduced a high level of exposure for both individuals and populations. Considering the high-exposure technological fields that were identified earlier, generalised approaches to reducing the accrued actual exposure include standardisation of specifications that allow competitive supply of complex components and complex substances, avoiding the large exposure of some contributory systems, retention of genuine alternatives (e.g. cash/gold as well as electronic transactions). cache = ./cache/cord-349581-o320ogmg.txt txt = ./txt/cord-349581-o320ogmg.txt === reduce.pl bib === === reduce.pl bib === id = cord-252343-a85wz2hs author = Skoda, Eva-Maria title = Psychological burden of healthcare professionals in Germany during the acute phase of the COVID-19 pandemic: differences and similarities in the international context date = 2020-08-07 pages = extension = .txt mime = text/plain words = 2912 sentences = 156 flesch = 51 summary = In total, 2224 HPs (physicians n = 492, nursing staff n = 1511, paramedics n = 221) and 10 639 non-healthcare professionals (nHPs) were assessed including generalized anxiety (Generalized Anxiety Disorder-7), depression (Patient Health Questionnaire-2), current health status (EQ-5D-3L), COVID-19-related fear, subjective level of information regarding COVID-19. RESULTS: HPs showed less generalized anxiety, depression and COVID-19-related fear and higher health status and subjective level of information regarding COVID-19 than the nHPs. Within the HP groups, nursing staff were the most psychologically burdened. In this study, nHPs reported overall higher levels of psychological burden than the HPs, which is particularly pronounced in generalized anxiety and depression scores. In the investigated sample, nursing staff seems to be the most vulnerable group for mental health burden during the COVID-19 pandemic, whereas a high subjective level of information seems to be associated with less psychological burden. cache = ./cache/cord-252343-a85wz2hs.txt txt = ./txt/cord-252343-a85wz2hs.txt === reduce.pl bib === id = cord-332432-q7u943k6 author = Hofkirchner, Wolfgang title = A paradigm shift for the Great Bifurcation date = 2020-06-30 pages = extension = .txt mime = text/plain words = 7661 sentences = 378 flesch = 46 summary = Since global challenges are problems of unprecedented complexity, it is argued that a secular paradigm shift is required away from the overemphasis on allegedly neutral standpoints, on a mechanistic picture of the world and on deductive logics towards accounts of emergence, of systemicity, informationality and conviviality, building upon each other and providing together a transdisciplinary edifice of the sciences, in the end, for, and by the inclusion of, citizens. For such a lesson to learn, a secular shift in thinking and acting throughout sciences and everyday life is required because human actors need to be capacitated to cope with complex challenges such as the global problems. Referring to Michael Tomasello's Shared Intentionality Hypothesis and his Interdependence Hypothesis (Tomasello et al., 2012; Tomasello, 2014; , there have been two key steps in anthroposociogenesis (the becoming of humans and society) so far and, following the new systemic, informational and convivialist paradigm, a possible third one is imminent. cache = ./cache/cord-332432-q7u943k6.txt txt = ./txt/cord-332432-q7u943k6.txt === reduce.pl bib === id = cord-035308-996ysogr author = Twining, Peter title = Developing a quality curriculum in a technological era date = 2020-11-11 pages = extension = .txt mime = text/plain words = 9388 sentences = 482 flesch = 50 summary = This provides a stimulus for national curricula to think more broadly about what knowledge, competencies and dispositions school students need to thrive and shape their world (e.g. see Erstad and Voogt 2018) and thus should be included in a quality curriculum; i.e. a 'plan for learning' which supports young people in acquiring the knowledge, competences and dispositions needed to be successful in the digital era. (2018) explored the issue of alignment, noting that this required alignment of purpose, policy (including curriculum, assessment, accountability and teacher professional learning), and practice at three levels (macro/national, meso/school, and micro/ teacher). Using a socio-cultural framework (Fig. 5) this paper illustrates the complexity of alignment of purpose, policy (including curriculum, assessment, accountability and teacher professional learning) and practice between and within each level (Constitutive Order, School Arena, and Setting). cache = ./cache/cord-035308-996ysogr.txt txt = ./txt/cord-035308-996ysogr.txt === reduce.pl bib === id = cord-296717-ay4wcmk3 author = Long, Wen title = Can the Chinese volatility index reflect investor sentiment? date = 2020-10-20 pages = extension = .txt mime = text/plain words = 7160 sentences = 430 flesch = 55 summary = In order to describe investor sentiment comprehensively, we build a three-dimensional investor sentiment measurement system composed of macro, meso and micro level, and decompose iVX into three components to obtain short-term, medium-term fluctuations and long-term trend by EEMD method. They use principal component analysis to extract a sentiment index from six variables of the stock market, including closed-end fund discount, NYSE share turnover, the number and average first-day returns on IPOs, the equity share in new issues, and the dividend premium. The contributions of this paper include the following three aspects: (1) This study seeks to examine systematically on whether iVX has the ability to represent sentiment, and analyze it at the macro, meso and micro levels, while previous studies rarely discuss this issue, especially for the newly released and short-lived Chinese volatility index iVX. (3) By employing dynamic factor analysis on different sentiment indexes with mixed-frequency to extract the common factor, we investigate whether iVX can comprehensively represent investor sentiments at different time scales. cache = ./cache/cord-296717-ay4wcmk3.txt txt = ./txt/cord-296717-ay4wcmk3.txt === reduce.pl bib === === reduce.pl bib === id = cord-006391-esnsa4u5 author = nan title = Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date = 1982 pages = extension = .txt mime = text/plain words = 44844 sentences = 2433 flesch = 50 summary = In our parallel tests using an excision-sample technique [2] which is considerably more sensitive than the DGHM procedure, we have observed the following mean reductions in the counts of accessible bacteria: iodine in ethanol, 96%; povidone-iodine, 89%; chlorhexidine in ethanol, 88%; iso-propanol, The purpose of this study was to compare radiation injury in Guinea Pig small bowel (1) devoid of contents (2) containing bile (3) containing pancreatic juice. Studies in vitro employing isolated perfused rat pancreas and stomach revealed following results: Mean basal pancreatic somatostatin release in normal, diabetic and transplanted rats were 12___3, 24-t-7, and 17__+4 pg/ml, respectively. As these changes appear closely correlated to the blood glucose levels which show a 30 % decrease at 4 h and progressive restoration towards normal values up to 24 h, attempts have been made to alter the insulin/glucagon ratio by glucose infusion after PH and study its relation to liver regeneration. cache = ./cache/cord-006391-esnsa4u5.txt txt = ./txt/cord-006391-esnsa4u5.txt === reduce.pl bib === id = cord-003532-lcgeingz author = nan title = 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date = 2019-03-19 pages = extension = .txt mime = text/plain words = 79997 sentences = 5146 flesch = 52 summary = It's proposed to evaluate the association between myocardial injury biomarkers, high-sensitive troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-ProBNP), with inflammatory mediators (IL-6, IL-1Β , IL-8, IL-10, IL-12 / IL-23p40, IL17A, IL-21 and TNF-α ) and biomarkers, C protein reactive (CPR) and procalcitonin (PCT), in septic patients Methods: This was a prospective cohort study performed in three intensive care units, from September 2007 to September 2010 enrolling patients with sepsis (infection associated with organ dysfunction), and septic shock (hypotension refractory by fluids infusion requiring vasopressor). Blood samples were collected up to 48h after the development of first organ dysfunction (D0) and on the 7th day after inclusion in the study (D7) Results: Ninety-five patients were enrolled, with median age 64 years (interquatile?48-78), APACHE II: median 19 (14-22), SOFA: median 8 (5-10); 24.2% were admitted in ICU with sepsis and 75.8% with septic shock. cache = ./cache/cord-003532-lcgeingz.txt txt = ./txt/cord-003532-lcgeingz.txt === reduce.pl bib === id = cord-022653-qa1uph35 author = nan title = Poster Discussion Session PDS date = 2017-08-30 pages = extension = .txt mime = text/plain words = 58292 sentences = 3300 flesch = 53 summary = 0206 | G protein coupled receptor kinase 2 (GRK2) regulates endothelial permeability induced by Bradykinin 0208 | Pharmacokinetics (PK) and pharmacodynamics (PD) of c1 esterase inhibitor of chronic urticaria challenges most commonly identified were the following: time of onset of disease; frequency/duration of and provoking factors for wheals; diurnal variation; occurrence in relation to weekends, holidays, and foreign travel; shape, size, and distribution of wheals; associated angioedema; associated subjective symptoms of lesions; family and personal history regarding urticaria, atopy; previous or current allergies, infections, internal diseases, or other possible causes; psychosomatic and psychiatric diseases; surgical implantations and events during surgery; gastric/ intestinal problems; induction by physical agents or exercise; use of drugs; food allergies; relationship to the menstrual cycle; smoking habits; type of work, hobbies; stress; quality of life and emotional impact; previous therapy and response to therapy, and previous diagnostic procedures/results. cache = ./cache/cord-022653-qa1uph35.txt txt = ./txt/cord-022653-qa1uph35.txt === reduce.pl bib === id = cord-004948-ad3i9wgj author = nan title = 7th International Congress on Amino Acids and Proteins : Vienna, Austria, August 6–10, 2001 date = 2001 pages = extension = .txt mime = text/plain words = 73534 sentences = 3588 flesch = 45 summary = Specific CTL were derived by immunization of HHD mice with tumor peptide extracts loaded on antigen presenting cells and with HHD transfected human tumor cell lines CTL induced against peptides from various tumors recognized tumor peptides more effectively than peptides extracted from normal tissues and also reacted with a serie of peptides derived from overexpressed candidate proteins, identified by differential display methods (SAGE, Microarrays) Comparison of CTL derived from HHD mice to CTL induced from patient's PBMC showed overlapping recognition of many candidate peptides. By comparison of pro-teomic cell maps from normal controls and individuals affected with lysosomal transport disorders we have selected and identified several candidate disease-causing proteins, which have to be further studied by mutation analysis and functional expression. The results of the in vitro studies available to date strongly suggest that its effects on neuronal amino acid transport processes is mediated via some novel extracellular mechanism controlling the H ϩ (and/or other ionic) concentrations of neurones. cache = ./cache/cord-004948-ad3i9wgj.txt txt = ./txt/cord-004948-ad3i9wgj.txt === reduce.pl bib === id = cord-015024-2xzc0uc5 author = nan title = ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date = 2010-08-31 pages = extension = .txt mime = text/plain words = 84393 sentences = 5234 flesch = 52 summary = We performed a prospective clinical study in a 17-bed multidisciplinary intensive care unit, including 21 patients with controlled mechanical ventilation and monitored with the Vigileo Ò monitor, for whom the decision to give fluids was taken due to the presence of circulatory, including arterial hypotension (MAP B 65 mmHg or systolic arterial pressure \90 mmHg), and preserved preload-responsiveness condition, defined as SVV C10%. The aim of this study was to compare and evaluate four severity scoring systems in intensive care unit (ICU), including APACHE II, APACHE III, SASP II and MODS in severe septic patient. A prospective observational study was performed in 16 mechanically ventilated critically ill patients (12 M, age 49 ± 17 yr, BMI 25 ± 5 kg/m 2 , ICU admission day 5 ± 3, APACHE II on study 20 ± 7; mean ± SD) and 6 healthy subjects (3 M, age 24 ± 9 year, BMI 24 ± 45 kg/m 2 ). cache = ./cache/cord-015024-2xzc0uc5.txt txt = ./txt/cord-015024-2xzc0uc5.txt === reduce.pl bib === id = cord-005646-xhx9pzhj author = nan title = 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date = 1996 pages = extension = .txt mime = text/plain words = 72031 sentences = 4734 flesch = 56 summary = Aims and methods The aim of both a prospective and retrospective survey conducted in German pediatric intensive care units in 1993 was to accumulate data on the epidemiology, risk factors, natural history and treatment strategies in a large group of pediatric ARDS patients who were treated in the tt~ee year period from 1991 to 1993.All patients had acute bilateral alveolar infiltration of noncardiogenic origin and a pO2~iO2 ratio < 150mmHg. The influence of sex, underlying disease and single organ failure was analyzed using the Fischer's exact test, the influence of additional organ failure on mortality was tested with the Cochran-Mantel-Haenszet statistics. cache = ./cache/cord-005646-xhx9pzhj.txt txt = ./txt/cord-005646-xhx9pzhj.txt === reduce.pl bib === id = cord-004879-pgyzluwp author = nan title = Programmed cell death date = 1994 pages = extension = .txt mime = text/plain words = 81677 sentences = 4465 flesch = 51 summary = Furthermore kinetic experiments after complementation of HIV=RT p66 with KIV-RT pSl indicated that HIV-RT pSl can restore rate and extent of strand displacement activity by HIV-RT p66 compared to the HIV-RT heterodimer D66/D51, suggesting a function of the 51 kDa polypeptide, The mouse mammary tumor virus proviral DNA contains an open reading frame in the 3' long terminal repeat which can code for a 36 kDa polypeptide with a putative transmembrane sequence and five N-linked glycosylation sites. To this end we used constructs encoding the c-fos (and c-jun) genes fused to the hormone-binding domain of the human estrogen receptor, designated c-FosER (and c-JunER), We could show that short-term activation (30 mins.) of c-FosER by estradiole (E2) led to the disruption of epithelial cell polarity within 24 hours, as characterized by the expression of apical and basolateral marker proteins. cache = ./cache/cord-004879-pgyzluwp.txt txt = ./txt/cord-004879-pgyzluwp.txt === reduce.pl bib === id = cord-015147-h0o0yqv8 author = nan title = Oral Communications and Posters date = 2014-09-12 pages = extension = .txt mime = text/plain words = 73711 sentences = 3862 flesch = 43 summary = Cyclooxygenases (COX) catalyze the first step in the synthesis of prostaglandins (PG) from arachidonic acid.COX-1 is constitutively expressed.The COX-2 gene is an immediate early-response gene that is induced by variety of mitogenic and inflammatory stimuli.Levels of COX-2 are increased in both inflamed and malignant tissues.In inflamed tissues, there is both pharmacological and genetic evidence that targeting COX-2 can either improve (e.g., osteoarthritis) or exacerbate symptoms (e.g., inflammatory bowel disease).Multiple lines of evidence suggest that COX-2 plays a significant role in carcinogenesis.The most specific data that support a cause-and effect relationship between COX-2 and tumorigenesis come from genetic studies.Overexpression of COX-2 has been observed to drive tumor formation whereas COX-2 deficiency protects against several tumor types.Selective COX-2 inhibitors protect against the formation and growth of experimental tumors.Moreover, selective COX-2 inhibitors are active in preventing colorectal adenomas in humans.Increased amounts of COX-2-derived PGE2 are found in both inflamed and neoplastic tissues.The fact that PGE2 can stimulate cell proliferation, inhibit apoptosis and induce angiogenesis fits with evidence that induction of COX-2 contributes to both wound healing and tumor growth.Taken together, it seems likely that COX-2 induction contributes to wound healing in response to injury but reduces the threshold for carcinogenesis. cache = ./cache/cord-015147-h0o0yqv8.txt txt = ./txt/cord-015147-h0o0yqv8.txt === reduce.pl bib === id = cord-006860-a3b8hyyr author = nan title = 40th Annual Meeting of the GTH (Gesellschaft für Thrombose- und Hämostaseforschung) date = 1996 pages = extension = .txt mime = text/plain words = 90660 sentences = 5152 flesch = 50 summary = Dept of Pediatrics, University Hospitals Kiel and Mtinster, Germany Resistance to activated protein C (APCR), in the majority of cases associated with the Arg 506 Gin point mutation in the factor V gene is present in more than 50 % of patients < 60 years of age with unexplained thrombophilia. The regular APC resistance test is not applicable to plasma from Orally anticoagulated (OAC) or heparinized patients due to decreased levels of vitamin K-dependent clotting factors and to thrombin inhibition by antithrombin, respectively. On admission an extensive coagulation screen yielded the following results (n/normal, t/elevated, I/reduced, +/positive, -/negative): PT t, aPTT t, Tr n, factor II, V, VIII n, factor VII, IX, XI, XII /,, fibrinogan t, ATIII n, protein C, S *, activated protein C sensitivity ratio 1.92 ($), FV-Leidenmutation PCR -, fibrinolytic system n, TAT t, Ft÷2 t, lupus anticoagulant +, heparin induced platelet antibodies +; no diagnosis of a specific autoimmuna disorder could be made. cache = ./cache/cord-006860-a3b8hyyr.txt txt = ./txt/cord-006860-a3b8hyyr.txt === reduce.pl bib === id = cord-015306-us58wwmp author = nan title = Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date = 2013-06-21 pages = extension = .txt mime = text/plain words = 71194 sentences = 4580 flesch = 53 summary = The incidence of renal involvement varies from 20 to 60% and there have been some reports showing that nephritis might be related to an older age at onset, persistent purpura (> 1 month), severe abdominal pain, and relapsing disease.Recently, several studies have shown that galactose-deficient IgA1 (Gd-IgA1) is recognized by anti-glycan antibodies, resulting in the formation of the circulating immune complexes and their mesangial deposition causing renal injury in HSP nephritis and serum galactose-deficient IgA1 levels were highly inherited in children with HSP nephritis.Regarding the treatment of HSP, one randomized double-blinded controlled study recently showed that patients with abdiminal pain or arthralgia may benefit from early treatment with prednisone, but the drug has not been proven to be capable of preventing the development of renal symptoms. cache = ./cache/cord-015306-us58wwmp.txt txt = ./txt/cord-015306-us58wwmp.txt === reduce.pl bib === id = cord-022633-fr55uod6 author = nan title = SAEM Abstracts, Plenary Session date = 2012-04-26 pages = extension = .txt mime = text/plain words = 147405 sentences = 8927 flesch = 54 summary = Staff satisfaction was evaluated through pre/ post-shift and study surveys; administrative data (physician initial assessment (PIA), length of stay (LOS), patients leaving without being seen (LWBS) and against medical advice [LAMA] ) were collected from an electronic, real-time ED information system. Communication Background: The link between extended shift lengths, sleepiness, and occupational injury or illness has been shown, in other health care populations, to be an important and preventable public health concern but heretofore has not been fully described in emergency medical services (EMS Objectives: To assess the effect of an ED-based computer screening and referral intervention for IPV victims and to determine what characteristics resulted in a positive change in their safety. Objectives: Using data from longitudinal surveys by the American Board of Emergency Medicine, the primary objective of this study was to evaluate if resident self-assessments of performance in required competencies improve over the course of graduate medical training and in the years following. cache = ./cache/cord-022633-fr55uod6.txt txt = ./txt/cord-022633-fr55uod6.txt === reduce.pl bib === id = cord-022650-phsr10jp author = nan title = Abstracts TPS date = 2018-08-14 pages = extension = .txt mime = text/plain words = 119675 sentences = 7010 flesch = 55 summary = 0685 | Skin prick test reactivity to aeroallergens in adult allergy clinic in a tertiary hospital: a 12-year retrospective study Results: Five different human sera were screened for specific IgE level against 29 different allergen sources using test methods of three different suppliers. Conclusion: This multicenter prospective study confirmed that stepwise single-dose OFC to egg will help to clarify the severity of egg allergy, and will contribute to improved food allergy manageMethod: The study design was a retrospective cohort study extracting data from the electronic chart of children older than 4 years who visited our out-patient clinic for egg or milk allergy and who underwent an oral food challenge test (OFC) twice within 24 months between November 2013 and December 2017. Results: In the base case analysis, using Italy clinical practice patients with moderate-to severe allergic rhino-conjunctivitis (SS ranging from 6 to 15 points) and a mean age at entry of 21 years, both SCIT and SLIT were associated with increased cost but superior efficacy compared to pharmacotherapy alone. cache = ./cache/cord-022650-phsr10jp.txt txt = ./txt/cord-022650-phsr10jp.txt === reduce.pl bib === id = cord-006229-7yoilsho author = nan title = Abstracts of the 82(nd) Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and the 18(th) Annual Meeting of the Network Clinical Pharmacology Germany (VKliPha) in cooperation with the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e.V. (AGAH) date = 2016-02-06 pages = extension = .txt mime = text/plain words = 133493 sentences = 6804 flesch = 42 summary = It directly activates Protein Kinase A (PKA) or the Exchange protein directly activated by cAMP (Epac) which is a guanine exchange factor (GEF) for the small monomeric GTPase Rap. As Human umbilical vein endothelial cells (HUVEC) express both cAMP effectors (Epac1 and PKA), we investigated the role of cAMP-signaling using a spheroid based sprouting assay as an in vitro model for angiogenesis. After activation, S1P receptors regulate important processes in the progression of renal diseases, such as mesangial cell migration Methods and Results: Here we demonstrate that dexamethasone treatment lowered S1P 1 mRNA and protein expression levels in rat mesangial cells measured by TaqMan® and Western blot analyses. The aim of this study was to investigate the relevance of IGFBP5 in cardiogenesis and cardiac remodeling and its role as a potential target for ameliorating stress-induced cardiac remodeling Methods and Results: We investigated the expression of Igfbp5 in murine cardiac tissue at different developmental stages by qPCR normalized to Tpt1 (Tumor Protein, Translationally-Controlled 1). cache = ./cache/cord-006229-7yoilsho.txt txt = ./txt/cord-006229-7yoilsho.txt === reduce.pl bib === id = cord-000083-3p81yr4n author = nan title = Poster Exhibition date = 2009-01-31 pages = extension = .txt mime = text/plain words = 112815 sentences = 7542 flesch = 56 summary = R. China Background: The objective of this study was to evaluate the early virologic response for prediction of achievement of HBeAg seroconversion and hepatitis B virus (HBV) DNA negativity after two years of lamivudine treatment in chronic hepatitis B (CHB) patients. Methods: A total of 620 patients who tested positive for hepatitis B surface antigen and were referred to Chiba University Hospital between February 1985 and March 2008 were included in the study, and their following characteristics were analyzed: age, gender, the status of HBeAg, ALT, HBV-DNA level, and PLT. Methods: A total of 60 patients with chronic hepatitis B, 32 (53.3%) were HBeAg positive (group A) while 28(46.7%) were HBeAg negative (group B) were included in this study after meeting the following criteria: age 18 to 60 years, HBsAg positive for more than 6 months, serum HBV-DNA was >5 log(10) copies/mL and ALT more than two times the upper normal limit. cache = ./cache/cord-000083-3p81yr4n.txt txt = ./txt/cord-000083-3p81yr4n.txt === reduce.pl bib === id = cord-023157-0lqlx2rv author = nan title = Poster Sessions date = 2013-04-18 pages = extension = .txt mime = text/plain words = 128430 sentences = 7726 flesch = 55 summary = The patients revealed the increase of free fatty acids level (2.19 AE 0.10) mmol/l/ml, that meaningfully differed from such indexes in the control group (P < 0.001) and low level of adiponektin (3.70 AE 0.70) mg/ml that confirms their role in development of NAFLD even for persons with normal body weight after the presence of abdominal type of adipose tissue distribution. Results: This study has shown effectiveness in reduction in fasting blood glucose (P < 0.01), systolic blood pressure (P = 0.03), diastolic blood pressure (P = 0.01), weight (P = 0.03), added sugar (P = 0.03) and fat consumption (P < 0.01) while improving physical activity (P < 0.01) and insulin sensitivity (P < 0.01) in the intervention group when compared with the control group at follow up assessment. Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. cache = ./cache/cord-023157-0lqlx2rv.txt txt = ./txt/cord-023157-0lqlx2rv.txt === reduce.pl bib === id = cord-006230-xta38e7j author = nan title = Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. date = 2012-02-22 pages = extension = .txt mime = text/plain words = 135419 sentences = 7042 flesch = 43 summary = Here, we will present our analysis of Ca 2+ signaling following stimulation of the FcεRI receptor and application of secretagogues that are supposed to affect Ca 2+ -dependent mast cell activation such as adenosine, endothelin-1, substance P and compound 48/80 in BMMCs and PMCs derived from mouse lines with inactivation of TRPC1, TRPC3, TRPC4, TRPC5 or TRPC6 since specific antagonists are still lacking for these TRP channels. These data indicate that increased PP2A activity is associated with modified gene expression in TG hearts possibly affecting stress response and regulation of cell signalling. As demonstrated by qPCR and Western blot experiments, mesangial cells showed a marked time-and dose-dependent upregulation of CSE mRNA and protein levels after treatment with platelet-derived growth factor (PDGF-BB). The transcription factor cAMP response element (CRE)-binding protein (CREB) plays a critical role in regulating gene expression in response to activation of the cAMPdependent signaling pathway, which is implicated in the pathophysiology of heart failure. cache = ./cache/cord-006230-xta38e7j.txt txt = ./txt/cord-006230-xta38e7j.txt === reduce.pl bib === id = cord-015021-pol2qm74 author = nan title = Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date = 1994 pages = extension = .txt mime = text/plain words = 162327 sentences = 9379 flesch = 50 summary = It is our current understanding that LPS is responsible for many of the pathophysiological events observed during gramnegative infections and that one of the major mechanisms leading to shock and death is the LPS-induced activation of macrophages resulting in the production and release of lipid and peptide mediators, among which tumor necrosis factor seems to be the most important. However plasma IL-6 estimation revealed a statistically significant reduction at 6 hours in tanrine-treated animals compared to glycino and TW controls ( Objective: To evaluate the effects of allogeneic blood transfusion, thermal injury and bacterial garage on interteukin 4 (IL-4), tumor necrosis factor alpha (TNF) production and host mortality and to study if the administration of thymopentth (THY) could affect these events. cache = ./cache/cord-015021-pol2qm74.txt txt = ./txt/cord-015021-pol2qm74.txt === reduce.pl bib === id = cord-005814-ak5pq312 author = nan title = 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date = 1995 pages = extension = .txt mime = text/plain words = 179164 sentences = 12028 flesch = 56 summary = Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life. cache = ./cache/cord-005814-ak5pq312.txt txt = ./txt/cord-005814-ak5pq312.txt === reduce.pl bib === id = cord-015394-uj7fe5y6 author = nan title = Scientific Abstracts date = 2008-12-23 pages = extension = .txt mime = text/plain words = 242330 sentences = 15267 flesch = 52 summary = Studies involving immunohistochemical analysis of normal ovaries have shown that granulosa cells express significantly higher levels of the activator protein-1 (AP-1) transcription factor, cFos compared to theca cells, where cFos expression is virtually absent. Following acute hypoxia (0.5% O2) for one to six hours, RhoA mRNA, total protein and activation (RhoA-GTP) levels were analysed, using semi-quantitative PCRs and western blot, and compared to normoxic non-pregnant human uterine smooth muscle control cells. Since there is an urgent need for non-invasive methods for determination of fetal (F) and placental (P) function, this study was designed to evaluate the genes differently and commonly expressed in P tissue and leukocytes in maternal (M) and F circulation.Material and Methods. The current study: 1) localized IL-6 mRNA levels in preeclamptic versus normal decidual sections; 2) evaluated mechanisms regulating IL-6 synthesis by targeting intracellular signaling pathways with specific inhibitors; 3) identified potential IL-6 targets by immunolocalizing the IL-6 receptor (IL-6R) to specific cell types in placental bed biopsies. cache = ./cache/cord-015394-uj7fe5y6.txt txt = ./txt/cord-015394-uj7fe5y6.txt === reduce.pl bib === id = cord-022940-atbjwpo5 author = nan title = Poster Sessions date = 2016-09-07 pages = extension = .txt mime = text/plain words = 241182 sentences = 12746 flesch = 47 summary = We have studied the effect of inhibition of IRE1 (inositol requiring enzyme 1), which is a central mediator of endoplasmic reticulum stress and controls cell proliferation and tumor growth, on hypoxic regulation of the expression of different proliferation related genes in U87 glioma cells. Transient inhibition of Akt and mTOR protein kinase activation in tumor cells followed by reactivation of signaling pathway did not result in a time-dependent difference on EGFR, HER2 and HER3 expression levels. In our study we aimed to determine cytotoxic effect of RES in K562 human CML cell line and to evaluate the expressions of miRNAs that are associated with genetics of leukemia after treatment with RES; to investigate target genes of miRNAs which show significant expression alterations and molecular mechanisms of RES treatment. cache = ./cache/cord-022940-atbjwpo5.txt txt = ./txt/cord-022940-atbjwpo5.txt ===== Reducing email addresses cord-005646-xhx9pzhj cord-015147-h0o0yqv8 Creating transaction Updating adr table ===== Reducing keywords cord-003520-f3jz59pt cord-022070-soqeje4z cord-018414-6ffhm895 cord-016300-vw11c2wt cord-011360-1n998win cord-015090-n6f4xupw cord-034746-uxhpufnv cord-018623-of9vx7og cord-017309-pt27efu1 cord-267237-wbwlfx7q cord-285151-zynor0b2 cord-254646-psolkrom cord-284694-bk6bnox0 cord-352687-gncmygda cord-102738-e5zojanb cord-121777-3zrnz9nc cord-312418-e4g5u1nz cord-312580-r57rkrya cord-015372-76xvzvdg cord-255575-640v00jg cord-005633-oyhpwut7 cord-022353-q2k2krnm cord-264427-frrq4h39 cord-104157-rivaoo73 cord-266034-811lov8f cord-270184-bq5p2gs6 cord-336201-fl606l3b cord-149748-ucsxbzen cord-035308-996ysogr cord-264749-m1awr1rm cord-006435-4o8uu6d5 cord-344656-xx76w7c0 cord-349831-0u9y35qo cord-332432-q7u943k6 cord-252343-a85wz2hs cord-015082-l629n8is cord-280040-xphxlaat cord-349581-o320ogmg cord-296717-ay4wcmk3 cord-006391-esnsa4u5 cord-004948-ad3i9wgj cord-022653-qa1uph35 cord-015024-2xzc0uc5 cord-003532-lcgeingz cord-005646-xhx9pzhj cord-004879-pgyzluwp cord-015147-h0o0yqv8 cord-015306-us58wwmp cord-006860-a3b8hyyr cord-022633-fr55uod6 cord-022650-phsr10jp cord-006229-7yoilsho cord-023157-0lqlx2rv cord-000083-3p81yr4n cord-015021-pol2qm74 cord-005814-ak5pq312 cord-006230-xta38e7j cord-015394-uj7fe5y6 cord-022940-atbjwpo5 Creating transaction Updating wrd table ===== Reducing urls cord-003520-f3jz59pt cord-034746-uxhpufnv cord-102738-e5zojanb cord-255575-640v00jg cord-264427-frrq4h39 cord-266034-811lov8f cord-264749-m1awr1rm cord-336201-fl606l3b cord-280040-xphxlaat cord-004948-ad3i9wgj cord-006229-7yoilsho cord-006230-xta38e7j cord-022940-atbjwpo5 Creating transaction Updating url table ===== Reducing named entities cord-003520-f3jz59pt cord-022070-soqeje4z cord-011360-1n998win cord-016300-vw11c2wt cord-018414-6ffhm895 cord-034746-uxhpufnv cord-267237-wbwlfx7q cord-018623-of9vx7og cord-285151-zynor0b2 cord-015090-n6f4xupw cord-254646-psolkrom cord-284694-bk6bnox0 cord-352687-gncmygda cord-121777-3zrnz9nc cord-102738-e5zojanb cord-312418-e4g5u1nz cord-017309-pt27efu1 cord-005633-oyhpwut7 cord-255575-640v00jg cord-264427-frrq4h39 cord-312580-r57rkrya cord-104157-rivaoo73 cord-266034-811lov8f cord-149748-ucsxbzen cord-015372-76xvzvdg cord-035308-996ysogr cord-264749-m1awr1rm cord-270184-bq5p2gs6 cord-022353-q2k2krnm cord-336201-fl606l3b cord-349831-0u9y35qo cord-006435-4o8uu6d5 cord-252343-a85wz2hs cord-344656-xx76w7c0 cord-015082-l629n8is cord-332432-q7u943k6 cord-349581-o320ogmg cord-296717-ay4wcmk3 cord-280040-xphxlaat cord-006391-esnsa4u5 cord-022653-qa1uph35 cord-003532-lcgeingz cord-015024-2xzc0uc5 cord-005646-xhx9pzhj cord-015306-us58wwmp cord-004948-ad3i9wgj cord-006860-a3b8hyyr cord-015147-h0o0yqv8 cord-004879-pgyzluwp cord-022633-fr55uod6 cord-022650-phsr10jp cord-023157-0lqlx2rv cord-000083-3p81yr4n cord-005814-ak5pq312 cord-006229-7yoilsho cord-015021-pol2qm74 cord-006230-xta38e7j cord-015394-uj7fe5y6 cord-022940-atbjwpo5 Creating transaction Updating ent table ===== Reducing parts of speech cord-022070-soqeje4z cord-003520-f3jz59pt cord-034746-uxhpufnv cord-011360-1n998win cord-016300-vw11c2wt cord-267237-wbwlfx7q cord-284694-bk6bnox0 cord-352687-gncmygda cord-018623-of9vx7og cord-285151-zynor0b2 cord-254646-psolkrom cord-121777-3zrnz9nc cord-005633-oyhpwut7 cord-312418-e4g5u1nz cord-255575-640v00jg cord-102738-e5zojanb cord-264427-frrq4h39 cord-266034-811lov8f cord-270184-bq5p2gs6 cord-252343-a85wz2hs cord-312580-r57rkrya cord-149748-ucsxbzen cord-104157-rivaoo73 cord-018414-6ffhm895 cord-035308-996ysogr cord-344656-xx76w7c0 cord-264749-m1awr1rm cord-296717-ay4wcmk3 cord-280040-xphxlaat cord-332432-q7u943k6 cord-015090-n6f4xupw cord-349581-o320ogmg cord-349831-0u9y35qo cord-017309-pt27efu1 cord-006435-4o8uu6d5 cord-336201-fl606l3b cord-015082-l629n8is cord-022353-q2k2krnm cord-015372-76xvzvdg cord-006391-esnsa4u5 cord-022653-qa1uph35 cord-004948-ad3i9wgj cord-005646-xhx9pzhj cord-003532-lcgeingz cord-015306-us58wwmp cord-015024-2xzc0uc5 cord-015147-h0o0yqv8 cord-004879-pgyzluwp cord-006860-a3b8hyyr cord-022650-phsr10jp cord-000083-3p81yr4n cord-006230-xta38e7j cord-023157-0lqlx2rv cord-022633-fr55uod6 cord-006229-7yoilsho cord-015021-pol2qm74 cord-005814-ak5pq312 cord-022940-atbjwpo5 cord-015394-uj7fe5y6 Creating transaction Updating pos table Building ./etc/reader.txt cord-022940-atbjwpo5 cord-023157-0lqlx2rv cord-022650-phsr10jp cord-022940-atbjwpo5 cord-022650-phsr10jp cord-023157-0lqlx2rv number of items: 59 sum of words: 2,660,615 average size in words: 55,429 average readability score: 47 nouns: patients; cells; results; study; levels; group; cell; expression; treatment; blood; protein; methods; level; data; time; activity; analysis; effect; effects; groups; age; control; disease; serum; years; response; risk; mice; days; conclusion; liver; role; studies; system; ml; plasma; patient; children; day; therapy; gene; increase; test; model; function; rate; proteins; changes; factor; type verbs: used; increasing; shown; compared; induced; include; associated; found; followed; determining; performed; measured; reduce; suggest; investigate; observed; decreased; evaluating; treat; identify; based; developed; study; assess; demonstrated; indicated; obtained; reported; received; related; lead; expressed; causes; involves; detecting; analyzed; provides; result; reveals; improve; occurred; require; known; presented; affected; bound; considered; given; mediated; inhibiting adjectives: significant; high; higher; different; human; clinical; specific; non; normal; low; first; inflammatory; acute; positive; severe; lower; mean; important; total; cardiac; renal; chronic; anti; early; present; new; dependent; negative; similar; common; metabolic; major; respiratory; several; healthy; pulmonary; immune; fetal; primary; septic; vascular; endothelial; medical; hepatic; various; possible; potential; many; single; multiple adverbs: also; significantly; however; well; respectively; therefore; even; previously; furthermore; statistically; recently; highly; especially; prior; still; often; moreover; critically; less; mainly; together; directly; alone; now; later; currently; frequently; strongly; clinically; approximately; finally; least; additionally; particularly; usually; immediately; specifically; potentially; yet; rather; first; widely; commonly; interestingly; almost; relatively; probably; subsequently; prospectively; far pronouns: we; it; our; their; its; they; i; them; he; she; us; his; her; one; itself; you; themselves; your; me; him; my; ashcs; ivig; himself; mg; s; ours; em; mrnas; il-; igg4; igfbp2; y€; thee; t2dm; siil-33; oneself; myself; mrs; itsn2; ifnyr-/-mice; aptt; adrb1; yourself; ykl-40; y401; y-27632; wi~; wether; w@ proper nouns: ICU; mg; C; University; ED; AE; TNF; II; kg; LPS; A; IL-6; PCR; B; T; L; M; HBV; Hospital; MS; CI; mRNA; Group; IgE; RNA; ELISA; ±; S; I; HCC; CT; BMI; S.; Department; D; Medical; K; DNA; ARDS; E.; G; HCV; M.; C.; Germany; selectin; IV; E; USA; III keywords: level; patient; study; result; increase; method; group; cell; conclusion; university; high; hospital; il-6; icu; tnf; pcr; dna; elisa; effect; blood; treatment; lps; expression; protein; mouse; day; year; objective; intensive; disease; control; care; ards; activity; western; system; rna; receptor; introduction; human; germany; ecmo; apache; test; sepsis; ros; research; rat; pulmonary; mortality one topic; one dimension: patients file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412238/ titles(s): Free Fatty Acids’ Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial three topics; one dimension: patients; patients; cells file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104449/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095534/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100643/ titles(s): Scientific Abstracts | 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts | Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. five topics; three dimensions: patients cells levels; patients study icu; cells cell protein; patients results study; levels cells cell file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104449/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159364/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087532/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159469/, https://www.ncbi.nlm.nih.gov/pubmed/32836326/ titles(s): Scientific Abstracts | SAEM Abstracts, Plenary Session | Programmed cell death | Abstracts TPS | The Causal Closure of Physics in Real World Contexts Type: cord title: keyword-level-cord date: 2021-05-25 time: 15:28 username: emorgan patron: Eric Morgan email: emorgan@nd.edu input: keywords:level ==== make-pages.sh htm files ==== make-pages.sh complex files ==== make-pages.sh named enities ==== making bibliographics id: cord-270184-bq5p2gs6 author: Alrubaiee, Gamil Ghaleb title: Knowledge, attitudes, anxiety, and preventive behaviours towards COVID-19 among health care providers in Yemen: an online cross-sectional survey date: 2020-10-13 words: 5559.0 sentences: 271.0 pages: flesch: 50.0 cache: ./cache/cord-270184-bq5p2gs6.txt txt: ./txt/cord-270184-bq5p2gs6.txt summary: METHODS: A descriptive, web-based-cross-sectional study was conducted among 1231 Yemeni HCPs. The COVID-19 related questionnaire was designed using Google forms where the responses were coded and analysed using the Statistical Package for the Social Sciences software package (IBM SPSS), version 22.0. The results further revealed that the majority of respondents had adequate knowledge, optimistic attitude, moderate level of anxiety, and high-performance in preventive behaviours, 69.8, 85.10%, 51.0 and 87.70%, respectively, towards COVID-19. The questionnaire consisted of 58 items that sought to collect information on the respondents'' knowledge, attitude, anxiety, and preventive behaviours toward COVID-19. This fact motivated the need to undertake the current study aiming to explore the level of knowledge, attitude, anxiety, and preventive behaviours among HCPs towards the outbreak of COVID-19 in the country. abstract: BACKGROUND: The growing incidence of coronavirus (COVID-19) continues to cause fear, anxiety, and panic amongst the community, especially for healthcare providers (HCPs), as the most vulnerable group at risk of contracting this new SARS-CoV-2 infection. To protect and enhance the ability of HCPs to perform their role in responding to COVID-19, healthcare authorities must help to alleviate the level of stress and anxiety amongst HCPs and the community. This will improve the knowledge, attitude and practice towards COVID-19, especially for HCPs. In addition, authorities need to comply in treating this virus by implementing control measures and other precautions. This study explores the knowledge, attitude, anxiety, and preventive behaviours among Yemeni HCPs towards COVID-19. METHODS: A descriptive, web-based-cross-sectional study was conducted among 1231 Yemeni HCPs. The COVID-19 related questionnaire was designed using Google forms where the responses were coded and analysed using the Statistical Package for the Social Sciences software package (IBM SPSS), version 22.0. Descriptive statistics and Pearson’s correlation coefficient test were also employed in this study. A p-value of < 0.05 with a 95% confidence interval was considered as statistically significant. The data collection phase commenced on 22nd April 2020, at 6 pm and finished on 26th April 2020 at 11 am. RESULTS: The results indicated that from the 1231 HCPs participating in this study, 61.6% were male, and 67% were aged between 20 and 30 years with a mean age of 29.29 ± 6.75. Most (86%) held a bachelor’s degree or above having at least 10 years of work experience or less (88.1%). However, while 57.1% of the respondents obtained their information via social networks and news media, a further 60.0% had never attended lectures/discussions about COVID-19. The results further revealed that the majority of respondents had adequate knowledge, optimistic attitude, moderate level of anxiety, and high-performance in preventive behaviours, 69.8, 85.10%, 51.0 and 87.70%, respectively, towards COVID-19. CONCLUSION: Although the Yemeni HCPs exhibited an adequate level of knowledge, optimistic attitude, moderate level of anxiety, and high-performance in preventive behaviours toward COVID-19, the results highlighted gaps, particularly in their knowledge and attitude towards COVID-19. url: https://doi.org/10.1186/s12889-020-09644-y doi: 10.1186/s12889-020-09644-y id: cord-003520-f3jz59pt author: Arabi, Yaseen M. title: Free Fatty Acids’ Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial date: 2019-02-13 words: 4280.0 sentences: 211.0 pages: flesch: 51.0 cache: ./cache/cord-003520-f3jz59pt.txt txt: ./txt/cord-003520-f3jz59pt.txt summary: title: Free Fatty Acids'' Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial Objectives: The objectives of this study were to evaluate the clinical and nutritional correlates of high free fatty acids (FFAs) level in critically ill patients and the association with outcomes, and to study the effect of short-term caloric restriction (permissive underfeeding) on FFAs level during critical illness. Conclusion: We conclude that high FFAs level in critically ill patients is associated with features of metabolic syndrome and is not affected by short-term permissive underfeeding. The aims of this study were (1) to evaluate the clinical and nutritional correlates of high FFAs level in critically ill patients and the association with outcomes, and (2) study the effect of short-term caloric restriction (permissive underfeeding) on FFAs level during critical illness. abstract: Objectives: The objectives of this study were to evaluate the clinical and nutritional correlates of high free fatty acids (FFAs) level in critically ill patients and the association with outcomes, and to study the effect of short-term caloric restriction (permissive underfeeding) on FFAs level during critical illness. Patients/Method: In this pre-planned sub-study of the PermiT (Permissive Underfeeding vs. Target Enteral Feeding in Adult Critically Ill Patients) trial, we included critically ill patients who were expected to stay for ≥14 days in the intensive care unit. We measured FFAs level on day 1, 3, 5, 7, and 14 of enrollment. Of 70 enrolled patients, 23 (32.8%) patients had high FFAs level (baseline FFAs level >0.45 mmol/L in females and >0.6 mmol/L in males). Results: Patients with high FFAs level were significantly older and more likely to be females and diabetics and they had lower ratio of partial pressure of oxygen to the fraction of inspired oxygen, higher creatinine, and higher total cholesterol levels than those with normal FFAs level. During the study period, patients with high FFAs level had higher blood glucose and required more insulin. On multivariable logistic regression analysis, the predictors of high baseline FFAs level were diabetes (adjusted odds ratio (aOR): 5.36; 95% confidence interval (CI): 1.56, 18.43, p = 0.008) and baseline cholesterol level (aOR, 4.29; 95% CI: 11.64, 11.19, p = 0.003). Serial levels of FFAs did not differ with time between permissive underfeeding and standard feeding groups. FFAs level was not associated with 90-day mortality (aOR: 0.49; 95% CI: 0.09, 2.60, p = 0.40). Conclusion: We conclude that high FFAs level in critically ill patients is associated with features of metabolic syndrome and is not affected by short-term permissive underfeeding. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412238/ doi: 10.3390/nu11020384 id: cord-266034-811lov8f author: Benameur, Karima title: Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020 date: 2020-09-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: There are few detailed investigations of neurologic complications in severe acute respiratory syndrome coronavirus 2 infection. We describe 3 patients with laboratory-confirmed coronavirus disease who had encephalopathy and encephalitis develop. Neuroimaging showed nonenhancing unilateral, bilateral, and midline changes not readily attributable to vascular causes. All 3 patients had increased cerebrospinal fluid (CSF) levels of anti-S1 IgM. One patient who died also had increased levels of anti-envelope protein IgM. CSF analysis also showed markedly increased levels of interleukin (IL)-6, IL-8, and IL-10, but severe acute respiratory syndrome coronavirus 2 was not identified in any CSF sample. These changes provide evidence of CSF periinfectious/postinfectious inflammatory changes during coronavirus disease with neurologic complications. url: https://www.ncbi.nlm.nih.gov/pubmed/32487282/ doi: 10.3201/eid2609.202122 id: cord-255575-640v00jg author: Binny, R. N. title: Early intervention is the key to success in COVID-19 control date: 2020-10-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: New Zealand responded to the COVID-19 pandemic with a combination of border restrictions and an Alert Level system that included strict stay-at-home orders. These interventions were successful in containing the outbreak and ultimately eliminating community transmission of COVID-19. The timing of interventions is crucial to their success. Delaying interventions for too long may both reduce their effectiveness and mean that they need to be maintained for a longer period of time. Here, we use a stochastic branching process model of COVID-19 transmission and control to simulate the epidemic trajectory in New Zealand and the effect of its interventions during its COVID-19 outbreak in March-April 2020. We use the model to calculate key outcomes, including the peak load on the contact tracing system, the total number of reported COVID-19 cases and deaths, and the probability of elimination within a specified time frame. We investigate the sensitivity of these outcomes to variations in the timing of the interventions. We find that a delay to the introduction of Alert Level 4 controls results in considerably worse outcomes. Changes in the timing of border measures have a smaller effect. We conclude that the rapid response in introducing stay-at-home orders was crucial in reducing the number of cases and deaths and increasing the probability of elimination. url: http://medrxiv.org/cgi/content/short/2020.10.20.20216457v1?rss=1 doi: 10.1101/2020.10.20.20216457 id: cord-149748-ucsxbzen author: Borowski, Elisa title: Disparities in ridesourcing demand for mobility resilience: A multilevel analysis of neighborhood effects in Chicago, Illinois date: 2020-10-29 words: 8850.0 sentences: 381.0 pages: flesch: 44.0 cache: ./cache/cord-149748-ucsxbzen.txt txt: ./txt/cord-149748-ucsxbzen.txt summary: Applying a natural experiment approach to newly released ridesourcing data, we examine variation in the gap-filling role of on-demand mobility during sudden shocks to a transportation system by analyzing the change in use of ridesourcing during unexpected rail transit service disruptions across the racially and economically diverse city of Chicago. The main contributions of this study are the insights it provides into: (1) whether ridesourcing is used as a gap-filling transportation mode during transit disruptions in Chicago, (2) whether its utilization for this purpose is distributed equitably across the city in terms of racial and economic circumstances, and (3) whether variation in ridesourcing demand during disruptions is attributable to station-level, community-level, or quadrant-level contexts. We use a multilevel regression analysis to identify the station level, community area level, and city quadrant level factors associated with systematic variations in ridesourcing demand during transit disruptions. abstract: Mobility resilience refers to the ability of individuals to complete their desired travel despite unplanned disruptions to the transportation system. The potential of new on-demand mobility options, such as ridesourcing services, to fill unpredicted gaps in mobility is an underexplored source of adaptive capacity. Applying a natural experiment approach to newly released ridesourcing data, we examine variation in the gap-filling role of on-demand mobility during sudden shocks to a transportation system by analyzing the change in use of ridesourcing during unexpected rail transit service disruptions across the racially and economically diverse city of Chicago. Using a multilevel mixed model, we control not only for the immediate station attributes where the disruption occurs, but also for the broader context of the community area and city quadrant in a three-level structure. Thereby the unobserved variability across neighborhoods can be associated with differences in factors such as transit ridership, or socio-economic status of residents, in addition to controlling for station level effects. Our findings reveal that individuals use ridesourcing as a gap-filling mechanism during rail transit disruptions, but there is strong variation across situational and locational contexts. Specifically, our results show larger increases in transit disruption responsive ridesourcing during weekdays, nonholidays, and more severe disruptions, as well as in community areas that have higher percentages of White residents and transit commuters, and on the more affluent northside of the city. These findings point to new insights with far-reaching implications on how ridesourcing complements existing transport networks by providing added capacity during disruptions but does not appear to bring equitable gap-filling benefits to low-income communities of color that typically have more limited mobility options. url: https://arxiv.org/pdf/2010.15889v1.pdf doi: nan id: cord-336201-fl606l3b author: Daryabor, Gholamreza title: The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System date: 2020-07-22 words: 13863.0 sentences: 715.0 pages: flesch: 38.0 cache: ./cache/cord-336201-fl606l3b.txt txt: ./txt/cord-336201-fl606l3b.txt summary: Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues and finally, insulin resistance, organ failure, and premature aging occur. T2DM, the most common form of diabetes (∼90%), is characterized by a systemic inflammatory disease accompanied by insulin resistance (IR) or decreased metabolic response to insulin in several tissues, including the adipose tissue, liver, and skeletal muscle, as well as by reduced insulin synthesis by pancreatic beta cells (4, 5) . During the progression of diabetes, hyperglycemia promotes mitochondrial dysfunction and induces the formation of reactive oxygen species (ROS) that cause oxidative stress in several tissues such as blood vessels and pancreatic beta cells (7) (8) (9) . In addition, the attachment of AGEs to their receptors [e.g., CD36, galectin-3, scavenger receptors types I (SR-A1), and II (SR-A2)] on the surfaces of immune cells in the circulation and tissues activates the expression of pro-inflammatory cytokines and increases free radical generation (18) . abstract: Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM). The field of immunometabolism implies a bidirectional link between the immune system and metabolism, in which inflammation plays an essential role in the promotion of metabolic abnormalities (e.g., obesity and T2DM), and metabolic factors, in turn, regulate immune cell functions. Obesity as the main inducer of a systemic low-level inflammation is a main susceptibility factor for T2DM. Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues and finally, insulin resistance, organ failure, and premature aging occur. Hyperglycemia and the subsequent inflammation are the main causes of micro- and macroangiopathies in the circulatory system. They also promote the gut microbiota dysbiosis, increased intestinal permeability, and fatty liver disease. The impaired immune system together with metabolic imbalance also increases the susceptibility of patients to several pathogenic agents such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, the need for a proper immunization protocol among such patients is granted. The focus of the current review is to explore metabolic and immunological abnormalities affecting several organs of T2DM patients and explain the mechanisms, whereby diabetic patients become more susceptible to infectious diseases. url: https://www.ncbi.nlm.nih.gov/pubmed/32793223/ doi: 10.3389/fimmu.2020.01582 id: cord-285151-zynor0b2 author: Eisenhut, Michael title: Neopterin in Diagnosis and Monitoring of Infectious Diseases date: 2013-12-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Neopterin is produced by activated monocytes, macrophages, and dendritic cells upon stimulation by interferon gamma produced by T-lymphocytes. Quantification of neopterin in body fluids has been achieved by standard high-performance liquid chromatography, radioimmunoassays, and enzyme-linked immunosorbent assays. Neopterin levels predict HIV-related mortality more efficiently than clinical manifestations. Successful highly active antiretroviral therapy is associated with a decrease in neopterin levels. Elevated neopterin levels were associated with hepatitis by hepatitis A, B, and C viruses. Serum neopterin levels were found to be a predictor of response to treatment of chronic HCV infection with pegylated interferon combined with ribavirin. Neopterin levels of patients with pulmonary tuberculosis were found to be higher in patients with more extensive radiological changes. Elimination of blood donors with elevated neopterin levels to reduce risk of transmission of infections with known and unknown viral pathogens has been undertaken. Neopterin measurement is hereby more cost effective but less sensitive than screening using polymerase chain reaction based assays. In conclusion neopterin is a nonspecific marker of activated T-helper cell 1 dominated immune response. It may be a useful marker for monitoring of infectious disease activity during treatment and for more accurate estimation of extent of disease and prognosis. url: https://doi.org/10.1155/2013/196432 doi: 10.1155/2013/196432 id: cord-349831-0u9y35qo author: Ellis, George F. R. title: The Causal Closure of Physics in Real World Contexts date: 2020-08-18 words: 15740.0 sentences: 965.0 pages: flesch: 60.0 cache: ./cache/cord-349831-0u9y35qo.txt txt: ./txt/cord-349831-0u9y35qo.txt summary: Secondly, I show that causal closure in the hierarchy of emergence is a strictly interlevel affair, and in the cases of engineering and biology encompasses all levels from the social level to the particle physics level. In particular, the particle physics level is not causally complete by itself in the contexts of solid state physics (because of interlevel wave–particle duality), digital computers (where algorithms determine outcomes), or biology (because of time dependent constraints). Here I want to examine the issue in a different way, by dealing in some detail with the hierarchical nature of emergence in real world contexts: the cases of engineering, based in the underlying solid state physics, and biology, based in the underlying molecular biology, in turn based in the underlying physics. Effective Causal Closure in real world contexts spans many levels, in the case of biology reaching down from the level of the organism to the underlying physics via time dependent constraints. abstract: The causal closure of physics is usually discussed in a context free way. Here I discuss it in the context of engineering systems and biology, where strong emergence takes place due to a combination of upwards emergence and downwards causation (Ellis, Emergence in Solid State Physics and Biology, 2020, arXiv:2004.13591). Firstly, I show that causal closure is strictly limited in terms of spatial interactions because these are cases that are of necessity strongly interacting with the environment. Effective Spatial Closure holds ceteris parabus, and can be violated by Black Swan Events. Secondly, I show that causal closure in the hierarchy of emergence is a strictly interlevel affair, and in the cases of engineering and biology encompasses all levels from the social level to the particle physics level. However Effective Causal Closure can usefully be defined for a restricted set of levels, and one can experimentally determine Effective Theories that hold at each level. This does not however imply those effective theories are causally complete by themselves. In particular, the particle physics level is not causally complete by itself in the contexts of solid state physics (because of interlevel wave–particle duality), digital computers (where algorithms determine outcomes), or biology (because of time dependent constraints). Furthermore Inextricably Intertwined Levels occur in all these contexts. url: https://www.ncbi.nlm.nih.gov/pubmed/32836326/ doi: 10.1007/s10701-020-00366-0 id: cord-017309-pt27efu1 author: Gupta, G. S. title: Selectins and Associated Adhesion Proteins in Inflammatory disorders date: 2012-03-20 words: 25423.0 sentences: 1303.0 pages: flesch: 40.0 cache: ./cache/cord-017309-pt27efu1.txt txt: ./txt/cord-017309-pt27efu1.txt summary: Activation of endothelial cells (EC) with different stimuli induces the expression of E-and P-selectins, and other adhesion molecules (ICAM-1, VCAM-1), involved in their interaction with circulating cells. Accordingly, population studies have explored the association of ischaemic heart disease with gene polymorphisms of the inflammatory molecules: tumor necrosis factors (TNF) a and b, transforming growth factors (TGF) b1 and 2, P and E selectins, and platelet endothelial cell adhesion molecule (PECAM) 1. Endothelial dysfunction in type 2 diabetic patients is associated with inflammation, increased levels of circulating soluble adhesion molecules (VCAM-1 and E-selectin), and inducing production of ROS, and urinary albumin excretion (Potenza et al. The A 561 C polymorphism of E-selectin gene may be associated with disease progression in patients with chronic HBV infection and control the expression of plasma soluble levels, while the G 98 T polymorphism may be related to fibrotic severity in Chinese population (Wu et al. abstract: Inflammation is defined as the normal response of living tissue to injury or infection. It is important to emphasize two components of this definition. First, that inflammation is a normal response and, as such, is expected to occur when tissue is damaged. Infact, if injured tissue does not exhibit signs of inflammation this would be considered abnormal and wounds and infections would never heal without inflammation. Secondly, inflammation occurs in living tissue, hence there is need for an adequate blood supply to the tissues in order to exhibit an inflammatory response. The inflammatory response may be triggered by mechanical injury, chemical toxins, and invasion by microorganisms, and hypersensitivity reactions. Three major events occur during the inflammatory response: the blood supply to the affected area is increased substantially, capillary permeability is increased, and leucocytes migrate from the capillary vessels into the surrounding interstitial spaces to the site of inflammation or injury. The inflammatory response represents a complex biological and biochemical process involving cells of the immune system and a plethora of biological mediators. Cell-to-cell communication molecules such as cytokines play an extremely important role in mediating the process of inflammation. Inflammation and platelet activation are critical phenomena in the setting of acute coronary syndromes. An extensive exposition of this complex phenomenon is beyond the scope of this article (Rankin 2004). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121831/ doi: 10.1007/978-3-7091-1065-2_44 id: cord-267237-wbwlfx7q author: Gómez-Rial, Jose title: Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology date: 2020-09-23 words: 2589.0 sentences: 148.0 pages: flesch: 40.0 cache: ./cache/cord-267237-wbwlfx7q.txt txt: ./txt/cord-267237-wbwlfx7q.txt summary: METHODS: Fifty-nine SARS-Cov-2 positive hospitalized patients, classified according to ICU or non-ICU admission requirement, were prospectively recruited and analyzed by ELISA for levels of sCD14 and sCD163, along with other laboratory parameters, and compared to a healthy control group. CONCLUSIONS: Monocyte-macrophage activation markers are increased and correlate with other inflammatory markers in SARS-Cov-2 infection, in association to hospital admission. In this paper, we analyze serum levels of soluble monocyte activation markers in COVID-19 patients and their correlation with severity and other inflammatory markers. We found significant correlations between sCD14 and sCD163 levels and several clinical laboratory parameters in infected patients (in these analysis, adjusted significance under Bonferrori correction is 0.01), but only in the non-ICU group, possibly reflecting an interference of the use of tocilizumab or corticoids in the ICU group. Our results thus suggest that monocyte-macrophage activation can act as driver cells of the cytokine storm and immunopathology associated to severe clinical course of COVID-19 patients. abstract: BACKGROUND: Emerging evidence indicates a potential role for monocytes in COVID-19 immunopathology. We investigated two soluble markers of monocyte activation, sCD14 and sCD163, in COVID-19 patients, with the aim of characterizing their potential role in monocyte-macrophage disease immunopathology. To the best of our knowledge, this is the first study of its kind. METHODS: Fifty-nine SARS-Cov-2 positive hospitalized patients, classified according to ICU or non-ICU admission requirement, were prospectively recruited and analyzed by ELISA for levels of sCD14 and sCD163, along with other laboratory parameters, and compared to a healthy control group. RESULTS: sCD14 and sCD163 levels were significantly higher among COVID-19 patients, independently of ICU admission requirement, compared to the control group. We found a significant correlation between sCD14 levels and other inflammatory markers, particularly Interleukin-6, in the non-ICU patients group. sCD163 showed a moderate positive correlation with the time lapsed from admission to sampling, independently of severity group. Treatment with corticoids showed an interference with sCD14 levels, whereas hydroxychloroquine and tocilizumab did not. CONCLUSIONS: Monocyte-macrophage activation markers are increased and correlate with other inflammatory markers in SARS-Cov-2 infection, in association to hospital admission. These data suggest a preponderant role for monocyte-macrophage activation in the development of immunopathology of COVID-19 patients. url: https://www.ncbi.nlm.nih.gov/pubmed/33072099/ doi: 10.3389/fimmu.2020.560381 id: cord-312580-r57rkrya author: Harcourt-Brown, Frances title: Chapter 6 Clinical pathology date: 2002-12-31 words: 12627.0 sentences: 822.0 pages: flesch: 51.0 cache: ./cache/cord-312580-r57rkrya.txt txt: ./txt/cord-312580-r57rkrya.txt summary: (1982) analysed the haematolog-• Rabbit blood clots quickly and haemolyses easily • Food deprivation does not guarantee a fasting blood sample as rabbits ingest caecotrophs • Stress associated with transport or handling can affect parameters such as blood glucose and the distribution of neutrophils and lymphocytes • Pregnancy, anaesthesia, blood collection techniques and intravenous fluid therapy will influence some blood results • Time of day can influence blood results as many parameters follow a duirnal rhythm in common with many physiological processes in rabbits • Laboratory reference ranges are often derived from animals of the same breed and strain. In two studies by Krueger (1988, 1989) controlled experimental infections with Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Candida albicans resulted in fever, increased plasma cortisol concentrations, neutrophilia and lymphopaenia but no significant increase in total white blood cell count. abstract: nan url: https://api.elsevier.com/content/article/pii/B9780750640022500096 doi: 10.1016/b978-075064002-2.50009-6 id: cord-332432-q7u943k6 author: Hofkirchner, Wolfgang title: A paradigm shift for the Great Bifurcation date: 2020-06-30 words: 7661.0 sentences: 378.0 pages: flesch: 46.0 cache: ./cache/cord-332432-q7u943k6.txt txt: ./txt/cord-332432-q7u943k6.txt summary: Since global challenges are problems of unprecedented complexity, it is argued that a secular paradigm shift is required away from the overemphasis on allegedly neutral standpoints, on a mechanistic picture of the world and on deductive logics towards accounts of emergence, of systemicity, informationality and conviviality, building upon each other and providing together a transdisciplinary edifice of the sciences, in the end, for, and by the inclusion of, citizens. For such a lesson to learn, a secular shift in thinking and acting throughout sciences and everyday life is required because human actors need to be capacitated to cope with complex challenges such as the global problems. Referring to Michael Tomasello''s Shared Intentionality Hypothesis and his Interdependence Hypothesis (Tomasello et al., 2012; Tomasello, 2014; , there have been two key steps in anthroposociogenesis (the becoming of humans and society) so far and, following the new systemic, informational and convivialist paradigm, a possible third one is imminent. abstract: This paper is an attempt to achieve an understanding of the situation the evolution of humanity is confronted with in the age of global challenges. Since global challenges are problems of unprecedented complexity, it is argued that a secular paradigm shift is required away from the overemphasis on allegedly neutral standpoints, on a mechanistic picture of the world and on deductive logics towards accounts of emergence, of systemicity, informationality and conviviality, building upon each other and providing together a transdisciplinary edifice of the sciences, in the end, for, and by the inclusion of, citizens. Viewed from such a combined perspective, the current social evolution is punctuated by a Great Bifurcation similar to bifurcations other emergent systems have been facing. On the one hand, humankind is on the brink of extinction. It is the world occurrence of the enclosure of commons that is detrimental to sharing the systemic synergy effects and thus to the cohesion of social systems. On the other hand, humanity is on the threshold of a planetary society. Another leap in integration would be the appropriate response to the complexity confronted with. Humans and their social systems are informational agents and, as such, they are able to generate requisite information and use it to catch up with the complex challenges. They can establish convivial rules of living together in that they disclose the commons world-wide. By doing so, they would accomplish another evolutionary step in anthroposociogenesis. The concept of the Global Sustainable Information Society describes the framework of necessary conditions of conviviality under the new circumstances. url: https://doi.org/10.1016/j.biosystems.2020.104193 doi: 10.1016/j.biosystems.2020.104193 id: cord-264427-frrq4h39 author: Huang, Ling title: The silver lining of COVID‐19: estimation of short‐term health impacts due to lockdown in the Yangtze River Delta region, China date: 2020-07-07 words: 3643.0 sentences: 174.0 pages: flesch: 51.0 cache: ./cache/cord-264427-frrq4h39.txt txt: ./txt/cord-264427-frrq4h39.txt summary: According to our calculation, total number of avoided premature death associated PM(2.5) reduction during the lockdown is estimated to be 42.4 thousand over the YRD region, with Shanghai, Wenzhou, Suzhou (Jiangsu province), Nanjing, and Nantong being the top five cities with largest health benefits. Utilizing simulated results based on an integrated meteorology and air quality modeling system, we estimate the number of avoided premature death due to lowered PM2.5 concentrations during COVID-19 lockdown over the YRD region. We calculate the premature mortality due to above-mentioned causes based on the health impact function (Eq. 1) over the YRD region during pre-lockdown, Level I, and Level II period of 2017-2020 (Fig. 4) . In this study, we attempt to quantify the health impacts associated PM2.5 improvement due to reduced human and industrial activities during COVID-19 lockdown in the Yangtze River Delta region, a region with heavy air pollution during the past years. abstract: The outbreak of COVID‐19 in China has led to massive lockdowns in order to reduce the spread of the epidemic and control human‐to‐human transmission. Subsequent reductions in various anthropogenic activities have led to improved air quality during the lockdown. In this study, we apply a widely used exposure‐response function to estimate the short‐term health impacts associated with PM(2.5) changes over the Yangtze River Delta (YRD) region due to COVID‐19 lockdown. Concentrations of PM(2.5) during lockdown period reduced by 22.9% to 54.0% compared to pre‐lockdown level. Estimated PM(2.5)‐related daily premature mortality during lockdown period is 895 (95% confidential interval: 637‐1081), which is 43.3% lower than pre‐lockdown period and 46.5% lower compared with averages of 2017‐2019. According to our calculation, total number of avoided premature death associated PM(2.5) reduction during the lockdown is estimated to be 42.4 thousand over the YRD region, with Shanghai, Wenzhou, Suzhou (Jiangsu province), Nanjing, and Nantong being the top five cities with largest health benefits. Avoided premature mortality is mostly contributed by reduced death associated with stroke (16.9 thousand, accounting for 40.0%), ischemic heart disease (14.0 thousand, 33.2%) and chronic obstructive pulmonary disease (7.6 thousand, 18.0%). Our calculations do not support or advocate any idea that pandemics produce a positive note to community health. We simply present health benefits from air pollution improvement due to large emission reductions from lowered human and industrial activities. Our results show that continuous efforts to improve air quality are essential to protect public health, especially over city‐clusters with dense population. url: https://www.ncbi.nlm.nih.gov/pubmed/32838101/ doi: 10.1029/2020gh000272 id: cord-016300-vw11c2wt author: Jain, Kewal K. title: Biomarkers of Pulmonary Diseases date: 2017-09-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Lungs and airways are affected by several pathologies, the most important of which are inflammation, infection and cancer. Some of the biomarkers of these pathologies are similar to those found in involvement of other organs. This chapter will briefly discuss general issues of biomarkers of pulmonary disorders listed in Table 16.1. Biomarkers of lung cancer are described in Chapter 13. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120545/ doi: 10.1007/978-1-4939-7431-3_16 id: cord-018414-6ffhm895 author: Kang, Yoogoo title: Anesthesia Management of Liver Transplantation date: 2016-07-22 words: 21155.0 sentences: 1064.0 pages: flesch: 34.0 cache: ./cache/cord-018414-6ffhm895.txt txt: ./txt/cord-018414-6ffhm895.txt summary: Specifically, patients with fulminant hepatic failure develop significant changes in cerebral function, and cerebral perfusion is maintained by monitoring cerebral blood flow and cerebral metabolic rate of oxygen, and intracranial pressure. Small-for-size syndrome develops in a patient who received a donor graft that was less than 1 % of the recipient''s body weight and is caused by decreased hepatic arterial flow in response to increased portal venous flow and pressure. The major criteria for the diagnosis of the hepatorenal syndrome are as follows: (1) advanced hepatic disease and portal hypertension; (2) low glomerular filtration rate (serum creatinine >1.5 mg/dL or creatinine clearance <40 mL/ min); (3) absence of nephrotoxic drug use, shock, systemic infection, or recent fluid losses; (4) lack of sustained improvement after diuretic withdrawal and volume resuscitation with 1.5 L of normal saline; (5) proteinuria (<500 mg/dL); and (6) no ultrasound evidence of urinary obstruction or parenchymal disease. abstract: Anesthesia for liver transplantation pertains to a continuum of critical care of patients with end-stage liver disease. Hence, anesthesiologists, armed with a comprehensive understanding of pathophysiology and physiologic effects of liver transplantation on recipients, are expected to maintain homeostasis of all organ function. Specifically, patients with fulminant hepatic failure develop significant changes in cerebral function, and cerebral perfusion is maintained by monitoring cerebral blood flow and cerebral metabolic rate of oxygen, and intracranial pressure. Hyperdynamic circulation is challenged by the postreperfusion syndrome, which may lead to cardiovascular collapse. The goal of circulatory support is to maintain tissue perfusion via optimal preload, contractility, and heart rate using the guidance of right-heart catheterization and transesophageal echocardiography. Portopulmonary hypertension and hepatopulmonary syndrome have high morbidity and mortality, and they should be properly evaluated preoperatively. Major bleeding is a common occurrence, and euvolemia is maintained using a rapid infusion device. Pre-existing coagulopathy is compounded by dilution, fibrinolysis, heparin effect, and excessive activation. It is treated using selective component or pharmacologic therapy based on the viscoelastic properties of whole blood. Hypocalcemia and hyperkalemia from massive transfusion, lack of hepatic function, and the postreperfusion syndrome should be aggressively treated. Close communication between all parties involved in liver transplantation is also equally valuable in achieving a successful outcome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123279/ doi: 10.1007/978-3-319-07209-8_9 id: cord-006435-4o8uu6d5 author: Kivity, Shaye title: Evidence for the Use of Intravenous Immunoglobulins—A Review of the Literature date: 2009-07-10 words: 14141.0 sentences: 874.0 pages: flesch: 36.0 cache: ./cache/cord-006435-4o8uu6d5.txt txt: ./txt/cord-006435-4o8uu6d5.txt summary: Although convincing evidence is lacking for the use of IVIg in view of the severity and the refractory nature of several cases of Evans'' syndrome, IVIg may be considered among the treatment options generally together with CS with or without immunosuppressive therapy (strength of recommendation IIb). Level of evidence B Evidence comes only from one crossover randomized placebo-controlled trial which supports the use of IVIg in HIV-associated thrombocytopenia, especially when platelet count is very low or the risk of bleeding is high (strength of recommendation IIa). Level of evidence B IVIg is not used for the treatment of CMV infection but may be helpful in treatment of hemophagocytic syndrome related to CMV and other viruses (see hematology section); there is some evidence for its effectiveness in preventing seroconversion in transplant patients who are immunosuppressed (strength of recommendation IIa). abstract: Intravenous immunoglobulins (IVIg) were first introduced in the middle of the twentieth century for the treatment of primary immunodeficiencies. In 1981, Paul Imbach noticed an improvement of immune-mediated thrombocytopenia, in patients receiving IVIg for immunodeficiencies. This opened a new era for the treatment of autoimmune conditions with IVIg. Since then, IVIg has become an important treatment option in a wide spectrum of diseases, including autoimmune and acute inflammatory conditions, most of them off-label (not included in the US Food and Drug Administration recommendation). A panel of immunologists and internists with experience in IVIg therapy reviewed the medical literature for published data concerning treatment with IVIg. The quality of evidence was assessed, and a summary of the available relevant literature in each disease was given. To our knowledge, this is the first all-inclusive comprehensive review, developed to assist the clinician when considering the use of IVIg in autoimmune diseases, immune deficiencies, and other conditions. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101816/ doi: 10.1007/s12016-009-8155-9 id: cord-102738-e5zojanb author: Lieberoth, Andreas title: Getting Humans to do Quantum Optimization - User Acquisition, Engagement and Early Results from the Citizen Cyberscience Game Quantum Moves date: 2015-06-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The game Quantum Moves was designed to pit human players against computer algorithms, combining their solutions into hybrid optimization to control a scalable quantum computer. In this midstream report, we open our design process and describe the series of constitutive building stages going into a quantum physics citizen science game. We present our approach from designing a core gameplay around quantum simulations, to putting extra game elements in place in order to frame, structure, and motivate players' difficult path from curious visitors to competent science contributors. The player base is extremely diverse - for instance, two top players are a 40 year old female accountant and a male taxi driver. Among statistical predictors for retention and in-game high scores, the data from our first year suggest that people recruited based on real-world physics interest and via real-world events, but only with an intermediate science education, are more likely to become engaged and skilled contributors. Interestingly, female players tended to perform better than male players, even though men played more games per day. To understand this relationship, we explore the profiles of our top players in more depth. We discuss in-world and in-game performance factors departing in psychological theories of intrinsic and extrinsic motivation, and the implications for using real live humans to do hybrid optimization via initially simple, but ultimately very cognitively complex games. url: https://arxiv.org/pdf/1506.08761v1.pdf doi: 10.15346/hc.v1i2.11 id: cord-296717-ay4wcmk3 author: Long, Wen title: Can the Chinese volatility index reflect investor sentiment? date: 2020-10-20 words: 7160.0 sentences: 430.0 pages: flesch: 55.0 cache: ./cache/cord-296717-ay4wcmk3.txt txt: ./txt/cord-296717-ay4wcmk3.txt summary: In order to describe investor sentiment comprehensively, we build a three-dimensional investor sentiment measurement system composed of macro, meso and micro level, and decompose iVX into three components to obtain short-term, medium-term fluctuations and long-term trend by EEMD method. They use principal component analysis to extract a sentiment index from six variables of the stock market, including closed-end fund discount, NYSE share turnover, the number and average first-day returns on IPOs, the equity share in new issues, and the dividend premium. The contributions of this paper include the following three aspects: (1) This study seeks to examine systematically on whether iVX has the ability to represent sentiment, and analyze it at the macro, meso and micro levels, while previous studies rarely discuss this issue, especially for the newly released and short-lived Chinese volatility index iVX. (3) By employing dynamic factor analysis on different sentiment indexes with mixed-frequency to extract the common factor, we investigate whether iVX can comprehensively represent investor sentiments at different time scales. abstract: The volatility index is the implied volatility calculated inversely from the option prices. This study investigates whether the official Chinese volatility index, iVX, can represent investor sentiment. In order to describe investor sentiment comprehensively, we build a three-dimensional investor sentiment measurement system composed of macro, meso and micro level, and decompose iVX into three components to obtain short-term, medium-term fluctuations and long-term trend by EEMD method. The relationships between iVX, its components and sentiment indexes at each level have been analyzed separately, and the empirical results reveal all components of iVX can reflect the investor sentiment at the corresponding level but to which extent they can reflect are not the same. Further we introduce the mixed-frequency dynamic factor analysis to extract the common sentiment factor, which shows stronger correlation with contemporaneous iVX, compared with the sentiment indexes at each level. The ADL model in robustness check also demonstrates the results. Our findings confirm iVX can represent the common sentiment and expectations of Chinese investors in different time scales. url: https://api.elsevier.com/content/article/pii/S1057521920302556 doi: 10.1016/j.irfa.2020.101612 id: cord-254646-psolkrom author: Matsui, Mary S. title: Vitamin D Update date: 2020-10-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: The goal of this review is to provide an update in the field of vitamin D, in particular, the role of vitamin D in non-skeletal health, the complexity of providing patient guidance regarding obtaining sufficient vitamin D, and the possible involvement of vitamin D in morbidity and mortality due to SARS-CoV-2 (COVID-19). RECENT FINDINGS: In addition to bone health, vitamin D may play a role in innate immunity, cardiovascular disease, and asthma. Although rickets is often regarded as an historical disease of the early twentieth century, it appears to be making a comeback worldwide, including “first-world” countries. Broad-spectrum sunscreens (with high UVA filters) that prevent erythema are unlikely to compromise vitamin D status in healthy populations. SUMMARY: New attention is now focused on the role of vitamin D in a variety of diseases, and more individualized patient recommendation schemes are being considered that take into account more realistic and achievable goals for achieving sufficient vitamin D through diet, supplements, and sun behavior. url: https://doi.org/10.1007/s13671-020-00315-0 doi: 10.1007/s13671-020-00315-0 id: cord-312418-e4g5u1nz author: Melillo, Alessandro title: Rabbit Clinical Pathology date: 2007-09-18 words: 6442.0 sentences: 363.0 pages: flesch: 46.0 cache: ./cache/cord-312418-e4g5u1nz.txt txt: ./txt/cord-312418-e4g5u1nz.txt summary: There is little information available that describes the effect of clinical disease on the blood parameters of companion rabbits, or on the use of blood tests as diagnostic and prognostic indicators. An intestinal isoenzyme is quite abundant, so serum ALP concentrations are actually the sum of these 3 isoenzymes, which may explain why many reference ranges are vague and wide and why raised ALP levels in clinically healthy animals are a common finding. Azotemia is also indicative of renal disease, usually affecting the rabbit patient in association with hyperkalemia or hypokalemia, hypercalcemia and coexisting hyperphosphatemia, nonregenerative anemia, and isostenuric urine. Blood urea levels below the reference range indicate hepatic insufficiency or muscle mass loss (e.g., dental disease). Hyperphosphatemia usually indicates chronic kidney failure (a loss of more than 80% of nephrons) given that serum phosphorus levels are normalized by compensatory mechanisms in early-onset renal disease. abstract: With rabbit patients, as in other species, analyzing blood and urine samples can be useful and informative, although interpretation of the results is sometimes challenging. This article summarizes the interpretation of laboratory results from rabbits. Hematological parameters can yield information about the red blood cell population and leukocyte response to stress and pathogens. Biochemistry evaluation can be used to investigate liver, kidney, and other organ function, and urinalysis results may yield additional information about kidney function and electrolyte imbalances. Serological tests are available for several pathogens of rabbits, including Encephalitozoon cuniculi, although the significance of positive results and antibody titers is not clear. Serum protein electrophoresis aids the understanding of protein disorders and the immune response to acute and chronic inflammation. url: https://api.elsevier.com/content/article/pii/S1557506307000857 doi: 10.1053/j.jepm.2007.06.002 id: cord-104157-rivaoo73 author: Noreika, Valdas title: Alertness fluctuations during task performance modulate cortical evoked responses to transcranial magnetic stimulation date: 2019-06-28 words: 10469.0 sentences: 492.0 pages: flesch: 52.0 cache: ./cache/cord-104157-rivaoo73.txt txt: ./txt/cord-104157-rivaoo73.txt summary: We observed rapid, non-linear changes in TMS-evoked neural responses – specifically, motor evoked potentials and TMS-evoked cortical potentials – as EEG activity indicated decreasing levels of alertness, even while participants remained awake and responsive in the behavioural task. Here we combined single-pulse TMS with concurrent EEG recording and a simple behavioural task to quantify changes in motor and cortical reactivity with fluctuating levels of alertness defined objectively on the basis of ongoing brain activity. To assess the instantaneous level of alertness, a two-fold EEG analysis was applied over the time window immediately preceding each TMS pulse: (1) a binary definition of awake and drowsy states following EEG spectral power signatures (θ/α) averaged across all EEG electrodes (Bareham et al., 2014) , and (2) a dynamical definition of alertness levels following a detailed sub-staging system for scoring the transition to N1 sleep (Hori et al., 1994) (Fig. 1C ). abstract: Transcranial magnetic stimulation (TMS) has been widely used in human cognitive neuroscience to examine the causal role of distinct cortical areas in perceptual, cognitive and motor functions. However, it is widely acknowledged that the effects of focal cortical stimulation on behaviour can vary substantially between participants and even from trial to trial within individuals. Here we asked whether spontaneous fluctuations in alertness can account for the variability in behavioural and neurophysiological responses to TMS. We combined single-pulse TMS with neural recording via electroencephalography (EEG) to quantify changes in motor and cortical reactivity with fluctuating levels of alertness defined objectively on the basis of ongoing brain activity. We observed rapid, non-linear changes in TMS-evoked neural responses – specifically, motor evoked potentials and TMS-evoked cortical potentials – as EEG activity indicated decreasing levels of alertness, even while participants remained awake and responsive in the behavioural task. IMPACT STATEMENT A substantial proportion of inter-trial variability in neurophysiological responses to TMS is due to spontaneous fluctuations in alertness, which should be controlled for during experimental and clinical applications of TMS. url: https://doi.org/10.1101/155754 doi: 10.1101/155754 id: cord-034746-uxhpufnv author: Nusshag, Christian title: Glomerular filtration barrier dysfunction in a self-limiting, RNA virus-induced glomerulopathy resembles findings in idiopathic nephrotic syndromes date: 2020-11-05 words: 3642.0 sentences: 194.0 pages: flesch: 36.0 cache: ./cache/cord-034746-uxhpufnv.txt txt: ./txt/cord-034746-uxhpufnv.txt summary: We therefore analyzed standard markers of glomerular proteinuria (e.g. immunoglobulin G [IgG]), urinary nephrin excretion (podocyte injury) and serum levels of the soluble urokinase plasminogen activator receptor (suPAR), a proposed pathomechanically involved molecule in INS, in PUUV-infected patients. On admission, patients suffering from hantavirus infection showed significantly increased urinary nephrin, IgG, α1-MG and serum suPAR levels compared to healthy controls (Fig. 3A ). Though, urinary biomarker levels decreased in both groups over time, patients with severe PCR showed significantly higher levels of nephrin, IgG, ACR and PCR during the first 48 h after admission ( Table 2 ). Our data show a strong association between urinary nephrin levels and the extent of (non-selective) glomerular proteinuria, suggesting that hantavirus infection causes a pronounced podocyte damage and subsequent impairment of the GFB. To date, one other study showed significantly elevated blood suPAR levels and their association with hantavirus disease severity but did not include nephrinuria and the extent of proteinuria in their analysis 19 . abstract: Podocyte injury has recently been described as unifying feature in idiopathic nephrotic syndromes (INS). Puumala hantavirus (PUUV) infection represents a unique RNA virus-induced renal disease with significant proteinuria. The underlying pathomechanism is unclear. We hypothesized that PUUV infection results in podocyte injury, similar to findings in INS. We therefore analyzed standard markers of glomerular proteinuria (e.g. immunoglobulin G [IgG]), urinary nephrin excretion (podocyte injury) and serum levels of the soluble urokinase plasminogen activator receptor (suPAR), a proposed pathomechanically involved molecule in INS, in PUUV-infected patients. Hantavirus patients showed significantly increased urinary nephrin, IgG and serum suPAR concentrations compared to healthy controls. Nephrin and IgG levels were significantly higher in patients with severe proteinuria than with mild proteinuria, and nephrin correlated strongly with biomarkers of glomerular proteinuria over time. Congruently, electron microcopy analyses showed a focal podocyte foot process effacement. suPAR correlated significantly with urinary nephrin, IgG and albumin levels, suggesting suPAR as a pathophysiological mediator in podocyte dysfunction. In contrast to INS, proteinuria recovered autonomously in hantavirus patients. This study reveals podocyte injury as main cause of proteinuria in hantavirus patients. A better understanding of the regenerative nature of hantavirus-induced glomerulopathy may generate new therapeutic approaches for INS. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644703/ doi: 10.1038/s41598-020-76050-0 id: cord-005633-oyhpwut7 author: Oppert, Michael title: Plasma cortisol levels before and during "low-dose" hydrocortisone therapy and their relationship to hemodynamic improvement in patients with septic shock date: 2000-11-18 words: 3935.0 sentences: 190.0 pages: flesch: 49.0 cache: ./cache/cord-005633-oyhpwut7.txt txt: ./txt/cord-005633-oyhpwut7.txt summary: Objectives: To compare cortisol levels during "low-dose" hydrocortisone therapy to basal and ACTH-stimulated endogenous levels and to assess whether clinical course and the need for catecholamines depend on cortisol levels and/or pretreatment adrenocortical responsiveness. Abstract Objectives: To compare cortisol levels during ªlow-doseº hydrocortisone therapy to basal and ACTH-stimulated endogenous levels and to assess whether clinical course and the need for catecholamines depend on cortisol levels and/or pretreatment adrenocortical responsiveness. Patients with ªinadequateº steroid production could be weaned from vasopressor therapy significantly faster, although their plasma free cortisol concentrations during the hydrocortisone treatment period did not differ. In contrast, two open studies [18, 19] and two recent randomized controlled trials [20, 21] have shown ªlowdoseº steroid therapy to have beneficial effects on hemodynamics and outcome in patients with septic shock, using no more than 300 mg hydrocortisone daily administered either as bolus injections of 100 mg three times daily or as continuous infusion. abstract: Objectives: To compare cortisol levels during "low-dose" hydrocortisone therapy to basal and ACTH-stimulated endogenous levels and to assess whether clinical course and the need for catecholamines depend on cortisol levels and/or pretreatment adrenocortical responsiveness. Design and setting: Prospective observational study in a medical ICU of a university hospital. Patients: Twenty consecutive patients with septic shock and a cardiac index of 3.5 l/min or higher, started on "low-dose" hydrocortisone therapy (100 mg bolus, 10 mg/h for 7 days and subsequent tapering) within 72 h of the onset of shock. Measurements and results: Basal total and free plasma cortisol levels ranged from 203 to 2169 and from 17 to 372 nmol/l. In 11 patients cortisol production was considered "inadequate" because there was neither a response to ACTH of at least 200 nmol/l nor a baseline level of at least 1000 nmol/l. Following the initiation of hydrocortisone therapy total and free cortisol levels increased 4.2- and 8.5-fold to median levels of 3587 (interquartile range 2679–5220) and 1210 (interquartile range 750–1846) nmol/l on day 1, and thereafter declined to median levels of 1310 nmol/l and 345 nmol/l on day 7. Patients with "inadequate" steroid production could be weaned from vasopressor therapy significantly faster, although their plasma free cortisol concentrations during the hydrocortisone treatment period did not differ. Conclusions: (a) During proposed regimens of "low-dose" hydrocortisone therapy, initially achieved plasma cortisol concentrations considerably exceed basal and ACTH stimulated levels. (b) Cortisol concentrations decline subsequently, despite continuous application of a constant dose. (c) "Inadequate" endogenous steroid production appears to sensitize patients to the hemodynamic effects of a "therapeutic rise" in plasma cortisol levels. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095044/ doi: 10.1007/s001340000685 id: cord-022070-soqeje4z author: Parry, Christopher M. title: Microbiology date: 2019-05-28 words: 3697.0 sentences: 185.0 pages: flesch: 37.0 cache: ./cache/cord-022070-soqeje4z.txt txt: ./txt/cord-022070-soqeje4z.txt summary: Most of the world''s population lacks access to accurate, affordable, easy-to-use, quality-assured, reliable, and accessible diagnostic tests and misdiagnosis of infectious diseases is common and compromises patient care. • Laboratories in resource-restricted settings struggle with poor facilities, lack of reliable water and electricity, inadequate equipment and consumables, insufficient staff, poor training and low morale, absence of standard operating procedures and quality assurance programs, and inadequate levels of biosafety. • Surveillance by microbiology laboratories provides an understanding of the causes of infection in the local population and the levels of antimicrobial resistance in key pathogens, and informs public health policy on appropriate antimicrobial therapy and preventive strategies. • There is increasing recognition of the need to support the development of a quality-assured laboratory service in resource-restricted settings and develop simple and robust point-of-care diagnostics both for routine clinical care and outbreak response. abstract: The management and containment of many treatable and preventable infectious diseases in resource-poor countries is limited by the failure to make an accurate diagnosis. Most of the world's population lacks access to accurate, affordable, easy-to-use, quality-assured, reliable, and accessible diagnostic tests and misdiagnosis of infectious diseases is common and compromises patient care. Laboratory diagnostics are also needed for the detection and surveillance of the increasing levels of antimicrobial resistance. Accurate clinical diagnosis in resource-poor settings relies strongly on the laboratory service, and the need to support the development of a quality-assured laboratory service in such settings is increasingly recognized. International organizations are actively working with local and national providers to improve laboratory services. The development of laboratory services will contribute to improved health for the local population, protection against emerging pathogens, and ensure better use of scarce health care resources. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152427/ doi: 10.1016/b978-0-323-55512-8.00021-1 id: cord-121777-3zrnz9nc author: Qian, Xuelin title: M3Lung-Sys: A Deep Learning System for Multi-Class Lung Pneumonia Screening from CT Imaging date: 2020-10-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: To counter the outbreak of COVID-19, the accurate diagnosis of suspected cases plays a crucial role in timely quarantine, medical treatment, and preventing the spread of the pandemic. Considering the limited training cases and resources (e.g, time and budget), we propose a Multi-task Multi-slice Deep Learning System (M3Lung-Sys) for multi-class lung pneumonia screening from CT imaging, which only consists of two 2D CNN networks, i.e., slice- and patient-level classification networks. The former aims to seek the feature representations from abundant CT slices instead of limited CT volumes, and for the overall pneumonia screening, the latter one could recover the temporal information by feature refinement and aggregation between different slices. In addition to distinguish COVID-19 from Healthy, H1N1, and CAP cases, our M 3 Lung-Sys also be able to locate the areas of relevant lesions, without any pixel-level annotation. To further demonstrate the effectiveness of our model, we conduct extensive experiments on a chest CT imaging dataset with a total of 734 patients (251 healthy people, 245 COVID-19 patients, 105 H1N1 patients, and 133 CAP patients). The quantitative results with plenty of metrics indicate the superiority of our proposed model on both slice- and patient-level classification tasks. More importantly, the generated lesion location maps make our system interpretable and more valuable to clinicians. url: https://arxiv.org/pdf/2010.03201v1.pdf doi: nan id: cord-349581-o320ogmg author: Robertson, Lindsay J. title: The technological ''exposure'' of populations; characterisation and future reduction date: 2020-05-25 words: 9151.0 sentences: 424.0 pages: flesch: 41.0 cache: ./cache/cord-349581-o320ogmg.txt txt: ./txt/cord-349581-o320ogmg.txt summary: The analysis of population exposure of a broad spectrum of needs showed that it was possible to identify some high exposure technological fields, specifically complex components, complex artificial substances, finance, communications, energy and information, These are considered more fully as follows; Although the feasibility of internet communications can be attributed to open source protocols, the practicality of current connectivity has been J o u r n a l P r e -p r o o f largely enabled by the very large data rates possible via fibre-optic cables, yet this capacity has also introduced a high level of exposure for both individuals and populations. Considering the high-exposure technological fields that were identified earlier, generalised approaches to reducing the accrued actual exposure include standardisation of specifications that allow competitive supply of complex components and complex substances, avoiding the large exposure of some contributory systems, retention of genuine alternatives (e.g. cash/gold as well as electronic transactions). abstract: The nature and level of individuals' exposure to technological systems has been explored previously and is briefly restated here. This paper demonstrates how the concept of technological exposure can be extended to generic needs of individuals, and further to the needs of populations of individuals and even as far as “existential threats” to humanity. Technological categories that incur high levels of population exposure are explored, and categories are described. A theoretical basis for reducing population exposure is developed from the basic concepts of technological exposure. Technological developments that potentially enable less centralised societies having lower levels of population exposure, are considered for practicality and effectiveness as are the factors that could allow and cause transition to a less technologically centralised model. Some conclusions regarding practicality, triggers, and issues arising from a decentralised society are considered and include the key conclusion that a higher level of decentralisation and exposure reduction is both desirable and possible. url: https://www.sciencedirect.com/science/article/pii/S0016328720300720?v=s5 doi: 10.1016/j.futures.2020.102584 id: cord-280040-xphxlaat author: Rutala, William A. title: Disinfection and Sterilization in Health Care Facilities An Overview and Current Issues date: 2016-09-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: When properly used, disinfection and sterilization can ensure the safe use of invasive and noninvasive medical devices. The method of disinfection and sterilization depends on the intended use of the medical device: critical items (contact sterile tissue) must be sterilized before use; semicritical items (contact mucous membranes or nonintact skin) must be high-level disinfected; and noncritical items (contact intact skin) should receive low-level disinfection. Cleaning should always precede high-level disinfection and sterilization. Current disinfection and sterilization guidelines must be strictly followed. url: https://www.sciencedirect.com/science/article/pii/S0891552016300228 doi: 10.1016/j.idc.2016.04.002 id: cord-264749-m1awr1rm author: Saad, Julian M. title: A philosophy of health: life as reality, health as a universal value date: 2020-03-18 words: 9761.0 sentences: 475.0 pages: flesch: 40.0 cache: ./cache/cord-264749-m1awr1rm.txt txt: ./txt/cord-264749-m1awr1rm.txt summary: The biological immune system, an individual''s system of health behaviors, and the social system will be observed as systems that generate maintainable-ease of functioning in cells, selves, and societies respectively (Fig. 2 ). To observe health at the level of the cell, the self, and the society simultaneously, we consider systems that support maintainable-ease of biological, behavioral, and social functioning. Through this philosophy, one can go beyond biological systems to observe how precision (in the form of hostdefense functions, decision-making/executive functions, and values) and variation (in the form of microbiota functions, habits/habitual life functions, and population-wide behaviors) integrate to generate to maintainable-ease of functioning in cells, selves, and societies simultaneously (Fig. 3) . Similarly, when behavioral and social exposures are not tailored to the needs of individuals and groups, populations can become resistant to healthy change, and health is no longer valued at the level of the self and the society. abstract: Emphases on biomarkers (e.g. when making diagnoses) and pharmaceutical/drug methods (e.g. when researching/disseminating population level interventions) in primary care evidence philosophies of health (and healthcare) that reduce health to the biological level. However, with chronic diseases being responsible for the majority of all cause deaths and being strongly linked to health behavior and lifestyle; predominantly biological views are becoming increasingly insufficient when discussing this health crisis. A philosophy that integrates biological, behavioral, and social determinants of health could benefit multidisciplinary discussions of healthy publics. This manuscript introduces a Philosophy of Health by presenting its first five principles of health. The philosophy creates parallels among biological immunity, health behavior change, social change by proposing that two general functions—precision and variation—impact population health at biological, behavioral, and social levels. This higher-level of abstraction is used to conclude that integrating functions, rather than separated (biological) structures drive healthy publics. A Philosophy of Health provides a framework that can integrate existing theories, models, concepts, and constructs. url: https://doi.org/10.1057/s41599-020-0420-9 doi: 10.1057/s41599-020-0420-9 id: cord-018623-of9vx7og author: Saghazadeh, Amene title: The Physical Burden of Immunoperception date: 2019-04-27 words: 5755.0 sentences: 262.0 pages: flesch: 37.0 cache: ./cache/cord-018623-of9vx7og.txt txt: ./txt/cord-018623-of9vx7og.txt summary: Further, human studies provided evidence pointing to the increased development of emotional problems and EDR-related disorders in patients with various types of AIDs, such as SLE and multiple sclerosis (MS), in a disease state/severity-dependent manner [12] [13] [14] [15] [16] [17] . Thus, it is not surprising that the inflammatory response and respective cytokines are supposed as one of the possible mechanisms linking the experience of negative emotions or ER-related disorders and the progression of cardiovascular diseases, of course along with the neuroendocrine system and apoptosis signaling pathways [27, 30, [32] [33] [34] [35] . Mice subjected to short-term (1-3 weeks) HFD also exhibited anxiety-like behaviors in addition to learning and memory impairments and had significantly higher levels of homovanillic acid-a metabolite of dopamine-in their hippocampus and cortex but without any alteration in the gene expression of inflammatory markers [89] . Increased emotional distress in daughters of breast cancer patients is associated with decreased natural cytotoxic activity, elevated levels of stress hormones and decreased secretion of Th1 cytokines abstract: The previous chapter introduced the ImmunoEmotional Regulatory System (IMMERS). Also, there was a brief discussion about psychological states/psychiatric disorders that so far have been linked to the IMMERS. The present chapter considers another aspect of the IMMERS in which physiological states/physical diseases can be fit to the IMMERS. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123546/ doi: 10.1007/978-3-030-10620-1_10 id: cord-344656-xx76w7c0 author: Sarder, MD title: Logistics customer services date: 2020-10-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This chapter discusses customer service in logistics in terms of different elements, the relative importance of those elements, and how these elements impact the effectiveness of logistics operations. It also explains the sales–service relation model and how to measure service level. Other topics include order cycle time, how to determine optimal service levels, and acceptable service variation in logistics. url: https://api.elsevier.com/content/article/pii/B9780128159743000083 doi: 10.1016/b978-0-12-815974-3.00008-3 id: cord-352687-gncmygda author: Science, Michelle title: Low Serum 25-Hydroxyvitamin D Level and Risk of Upper Respiratory Tract Infection in Children and Adolescents date: 2013-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background. Vitamin D may be important for immune function. Studies to date have shown an inconsistent association between vitamin D and infection with respiratory viruses. The purpose of this study was to determine if serum 25-hydroxyvitamin D (25(OH)D) was associated with laboratory-confirmed viral respiratory tract infections (RTIs) in children. Methods. Serum 25(OH)D levels were measured at baseline and children from Canadian Hutterite communities were followed prospectively during the respiratory virus season. Nasopharyngeal specimens were obtained if symptoms developed and infections were confirmed using polymerase chain reaction. The association between serum 25(OH)D and time to laboratory-confirmed viral RTI was evaluated using a Cox proportional hazards model. Results. Seven hundred forty-three children aged 3–15 years were followed between 22 December 2008 and 23 June 2009. The median serum 25(OH)D level was 62.0 nmol/L (interquartile range, 51.0–74.0). A total of 229 participants (31%) developed at least 1 laboratory-confirmed viral RTI. Younger age and lower serum 25(OH)D levels were associated with increased risk of viral RTI. Serum 25(OH)D levels <75 nmol/L increased the risk of viral RTI by 50% (hazard ratio [HR], 1.51; 95% confidence interval [CI], 1.10–2.07, P = .011) and levels <50 nmol/L increased the risk by 70% (HR, 1.67; 95% CI, 1.16–2.40, P = .006). Conclusions. Lower serum 25(OH)D levels were associated with increased risk of laboratory-confirmed viral RTI in children from Canadian Hutterite communities. Interventional studies evaluating the role of vitamin D supplementation to reduce the burden of viral RTIs are warranted. url: https://academic.oup.com/cid/article-pdf/57/3/392/17854249/cit289.pdf doi: 10.1093/cid/cit289 id: cord-252343-a85wz2hs author: Skoda, Eva-Maria title: Psychological burden of healthcare professionals in Germany during the acute phase of the COVID-19 pandemic: differences and similarities in the international context date: 2020-08-07 words: 2912.0 sentences: 156.0 pages: flesch: 51.0 cache: ./cache/cord-252343-a85wz2hs.txt txt: ./txt/cord-252343-a85wz2hs.txt summary: In total, 2224 HPs (physicians n = 492, nursing staff n = 1511, paramedics n = 221) and 10 639 non-healthcare professionals (nHPs) were assessed including generalized anxiety (Generalized Anxiety Disorder-7), depression (Patient Health Questionnaire-2), current health status (EQ-5D-3L), COVID-19-related fear, subjective level of information regarding COVID-19. RESULTS: HPs showed less generalized anxiety, depression and COVID-19-related fear and higher health status and subjective level of information regarding COVID-19 than the nHPs. Within the HP groups, nursing staff were the most psychologically burdened. In this study, nHPs reported overall higher levels of psychological burden than the HPs, which is particularly pronounced in generalized anxiety and depression scores. In the investigated sample, nursing staff seems to be the most vulnerable group for mental health burden during the COVID-19 pandemic, whereas a high subjective level of information seems to be associated with less psychological burden. abstract: BACKGROUND: Healthcare professionals (HPs) are the key figures to keep up the healthcare system during the COVID-19 pandemic and thus are one of the most vulnerable groups in this. To this point, the extent of this psychological burden, especially in Europe and Germany, remains unclear. This is the first study investigating German HPs after the COVID-19 outbreak. METHODS: We performed an online-based cross-sectional study after the COVID-19 outbreak in Germany (10–31 March 2020). In total, 2224 HPs (physicians n = 492, nursing staff n = 1511, paramedics n = 221) and 10 639 non-healthcare professionals (nHPs) were assessed including generalized anxiety (Generalized Anxiety Disorder-7), depression (Patient Health Questionnaire-2), current health status (EQ-5D-3L), COVID-19-related fear, subjective level of information regarding COVID-19. RESULTS: HPs showed less generalized anxiety, depression and COVID-19-related fear and higher health status and subjective level of information regarding COVID-19 than the nHPs. Within the HP groups, nursing staff were the most psychologically burdened. Subjective levels of information regarding COVID-19 correlated negatively with generalized anxiety levels across all groups. Among HPs, nursing staff showed the highest and paramedics the lowest generalized anxiety levels. CONCLUSIONS: In the context of COVID-19, German HPs seem to be less psychological burdened than nHPs, and also less burdened compared with existing international data. url: https://doi.org/10.1093/pubmed/fdaa124 doi: 10.1093/pubmed/fdaa124 id: cord-035308-996ysogr author: Twining, Peter title: Developing a quality curriculum in a technological era date: 2020-11-11 words: 9388.0 sentences: 482.0 pages: flesch: 50.0 cache: ./cache/cord-035308-996ysogr.txt txt: ./txt/cord-035308-996ysogr.txt summary: This provides a stimulus for national curricula to think more broadly about what knowledge, competencies and dispositions school students need to thrive and shape their world (e.g. see Erstad and Voogt 2018) and thus should be included in a quality curriculum; i.e. a ''plan for learning'' which supports young people in acquiring the knowledge, competences and dispositions needed to be successful in the digital era. (2018) explored the issue of alignment, noting that this required alignment of purpose, policy (including curriculum, assessment, accountability and teacher professional learning), and practice at three levels (macro/national, meso/school, and micro/ teacher). Using a socio-cultural framework (Fig. 5) this paper illustrates the complexity of alignment of purpose, policy (including curriculum, assessment, accountability and teacher professional learning) and practice between and within each level (Constitutive Order, School Arena, and Setting). abstract: There is considerable rhetoric internationally around the need for national curricula to reflect the changes that are taking place in the world outside school. This raises questions about what a quality curriculum in a technological era should look like, and equally challenging issues about how to achieve the necessary changes in schooling in order for such a curriculum to be realised. This paper summarises the views of 11 experts from seven countries. It introduces a sociocultural framework that highlights the complexity of achieving alignment between policies and practice spanning the national to local school to classroom levels. Three key issues that underpin alignment are then explored, each of which link with the issue of trust: stakeholders engagement; teacher professionalism; summative assessment. By exploring and exemplifying these three issues the paper indicates potential ways of addressing them and provides ‘tools to think with’ to enhance future curriculum development initiatives. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657067/ doi: 10.1007/s11423-020-09857-3 id: cord-022353-q2k2krnm author: W. Quimby, Fred title: Clinical Chemistry of the Laboratory Mouse date: 2007-09-02 words: 30195.0 sentences: 1702.0 pages: flesch: 48.0 cache: ./cache/cord-022353-q2k2krnm.txt txt: ./txt/cord-022353-q2k2krnm.txt summary: Assessment of long-term average blood glucose levels in mice is also available by RIAs measuring glycosylated hemoglobin and glycosylated serum proteins (collectively known as fructosamines) (Gould et al. Leptin resistance, a common feature of obesity in mice and humans, has also been shown to result, in part, from the shedding of membrane-bound hepatic leptin receptors into the plasma, where soluble receptors modulate circulating leptin levels and possibly its biologic activity (Cohen et al. d. OTHER ANALYTES ASSOCIATED WITH LIPID METABOLISM AND ATHEROSCLEROSIS IN MICE ELISA kits are commercially available for the quantitation of many mouse coagulation proteins including: fibrinogen, factor VII, d-dimer, tissue factor, and von Willebrand''s factor antigen. The ability of the first component of complement, C1, to bind specific sites on the heavy chain of mouse IgG2b and activate a sequence of reactions leading to production of a molecular unit capable of lysing a target cell membrane has established the complement system as the primary mediator of antibody-antigen reactions. abstract: The frontier of clinical chemistry in the mouse has advanced and expanded because of two major events such as, the increasing reliance on mice in biomedical research, and increasing availability of practical yet sophisticated techniques and instrumentations that have allowed for the detection of a wider variety of biomarkers of disease. The progression of these two events is partially driven by the increasing regulatory demands related to safety/toxicity assessment of novel drug development. The availability of inbred strains has led to major breakthroughs in cancer, biology, and immunology. In addition, outbred stocks continue to be utilized in a wide variety of studies but particularly in the fields of toxicology and pharmacology. The power of these models to elucidate the genetic basis of disease cannot be overemphasized. This provided complete nucleotide sequences for each genome allowing investigators to quickly develop the equivalent murine model for many of the inherited human diseases. Transgenic and knockout mice have helped clarify disease pathogenesis in virtually every area of medicine and often elucidated biochemical pathways, previously unknown, which are now subject to testing and quantification. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155603/ doi: 10.1016/b978-012369454-6/50060-1 id: cord-284694-bk6bnox0 author: Wang, Changsong title: Cytokine Levels in the Body Fluids of a Patient With COVID-19 and Acute Respiratory Distress Syndrome: A Case Report date: 2020-05-12 words: 559.0 sentences: 28.0 pages: flesch: 46.0 cache: ./cache/cord-284694-bk6bnox0.txt txt: ./txt/cord-284694-bk6bnox0.txt summary: title: Cytokine Levels in the Body Fluids of a Patient With COVID-19 and Acute Respiratory Distress Syndrome: A Case Report In addition, the time from symptom onset to confirmation of COVID-19 diagnosis was relatively long, the patient''s hospital course was longer, and we wonder whether this long duration of viral replication contributed to the high cytokine levels we measured. As a result, we wonder whether tocilizumab would have affected the IL-6 levels we observed and whether it might have improved this patient''s disease course, especially because others have reported that as COVID-19 progresses to its middle and late stages, the expression of inflammatory cytokines is related to the severity of the disease (4). On the basis of our experience, we encourage additional research to determine whether inflammatory cytokines in the lungs predict the clinical course of COVID-19 and whether these cytokines should be a target for intervention and treatment. abstract: nan url: https://doi.org/10.7326/l20-0354 doi: 10.7326/l20-0354 id: cord-011360-1n998win author: Zloto, Keren title: Preoperative miRNA-208a as a Predictor of Postoperative Complications in Children with Congenital Heart Disease Undergoing Heart Surgery date: 2019-11-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Major perioperative cardiovascular events are important causes of morbidity in pediatric patients with congenital heart disease who undergo reparative surgery. Current preoperative clinical risk assessment strategies have poor accuracy for identifying patients who will sustain adverse events following heart surgery. There is an ongoing need to integrate clinical variables with novel technology and biomarkers to accurately predict outcome following pediatric heart surgery. We tested whether preoperative levels of miRNAs-208a can serve as such a biomarker. Serum samples were obtained from pediatric patients immediately before heart surgery. MiRNA-208a was quantified by RQ-PCR. Correlations between the patient’s clinical variables and miRNA levels were tested. Lower levels of preoperative miRNA-208a correlated with and could predict the appearance of postoperative cardiac and inflammatory complications. MiRNA-208a may serve as a biomarker for the prediction of patients who are at risk to develop complications following surgery for the repair of congenital heart defects. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224117/ doi: 10.1007/s12265-019-09921-1 id: cord-000083-3p81yr4n author: nan title: Poster Exhibition date: 2009-01-31 words: 112815.0 sentences: 7542.0 pages: flesch: 56.0 cache: ./cache/cord-000083-3p81yr4n.txt txt: ./txt/cord-000083-3p81yr4n.txt summary: R. China Background: The objective of this study was to evaluate the early virologic response for prediction of achievement of HBeAg seroconversion and hepatitis B virus (HBV) DNA negativity after two years of lamivudine treatment in chronic hepatitis B (CHB) patients. Methods: A total of 620 patients who tested positive for hepatitis B surface antigen and were referred to Chiba University Hospital between February 1985 and March 2008 were included in the study, and their following characteristics were analyzed: age, gender, the status of HBeAg, ALT, HBV-DNA level, and PLT. Methods: A total of 60 patients with chronic hepatitis B, 32 (53.3%) were HBeAg positive (group A) while 28(46.7%) were HBeAg negative (group B) were included in this study after meeting the following criteria: age 18 to 60 years, HBsAg positive for more than 6 months, serum HBV-DNA was >5 log(10) copies/mL and ALT more than two times the upper normal limit. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712310/ doi: 10.1007/s12072-009-9123-4 id: cord-003532-lcgeingz author: nan title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 words: 79997.0 sentences: 5146.0 pages: flesch: 52.0 cache: ./cache/cord-003532-lcgeingz.txt txt: ./txt/cord-003532-lcgeingz.txt summary: It''s proposed to evaluate the association between myocardial injury biomarkers, high-sensitive troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-ProBNP), with inflammatory mediators (IL-6, IL-1Β , IL-8, IL-10, IL-12 / IL-23p40, IL17A, IL-21 and TNF-α ) and biomarkers, C protein reactive (CPR) and procalcitonin (PCT), in septic patients Methods: This was a prospective cohort study performed in three intensive care units, from September 2007 to September 2010 enrolling patients with sepsis (infection associated with organ dysfunction), and septic shock (hypotension refractory by fluids infusion requiring vasopressor). Blood samples were collected up to 48h after the development of first organ dysfunction (D0) and on the 7th day after inclusion in the study (D7) Results: Ninety-five patients were enrolled, with median age 64 years (interquatile?48-78), APACHE II: median 19 (14-22), SOFA: median 8 (5-10); 24.2% were admitted in ICU with sepsis and 75.8% with septic shock. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423782/ doi: 10.1186/s13054-019-2358-0 id: cord-004879-pgyzluwp author: nan title: Programmed cell death date: 1994 words: 81677.0 sentences: 4465.0 pages: flesch: 51.0 cache: ./cache/cord-004879-pgyzluwp.txt txt: ./txt/cord-004879-pgyzluwp.txt summary: Furthermore kinetic experiments after complementation of HIV=RT p66 with KIV-RT pSl indicated that HIV-RT pSl can restore rate and extent of strand displacement activity by HIV-RT p66 compared to the HIV-RT heterodimer D66/D51, suggesting a function of the 51 kDa polypeptide, The mouse mammary tumor virus proviral DNA contains an open reading frame in the 3'' long terminal repeat which can code for a 36 kDa polypeptide with a putative transmembrane sequence and five N-linked glycosylation sites. To this end we used constructs encoding the c-fos (and c-jun) genes fused to the hormone-binding domain of the human estrogen receptor, designated c-FosER (and c-JunER), We could show that short-term activation (30 mins.) of c-FosER by estradiole (E2) led to the disruption of epithelial cell polarity within 24 hours, as characterized by the expression of apical and basolateral marker proteins. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087532/ doi: 10.1007/bf02033112 id: cord-004948-ad3i9wgj author: nan title: 7th International Congress on Amino Acids and Proteins : Vienna, Austria, August 6–10, 2001 date: 2001 words: 73534.0 sentences: 3588.0 pages: flesch: 45.0 cache: ./cache/cord-004948-ad3i9wgj.txt txt: ./txt/cord-004948-ad3i9wgj.txt summary: Specific CTL were derived by immunization of HHD mice with tumor peptide extracts loaded on antigen presenting cells and with HHD transfected human tumor cell lines CTL induced against peptides from various tumors recognized tumor peptides more effectively than peptides extracted from normal tissues and also reacted with a serie of peptides derived from overexpressed candidate proteins, identified by differential display methods (SAGE, Microarrays) Comparison of CTL derived from HHD mice to CTL induced from patient''s PBMC showed overlapping recognition of many candidate peptides. By comparison of pro-teomic cell maps from normal controls and individuals affected with lysosomal transport disorders we have selected and identified several candidate disease-causing proteins, which have to be further studied by mutation analysis and functional expression. The results of the in vitro studies available to date strongly suggest that its effects on neuronal amino acid transport processes is mediated via some novel extracellular mechanism controlling the H ϩ (and/or other ionic) concentrations of neurones. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087755/ doi: 10.1007/s007260170030 id: cord-005646-xhx9pzhj author: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 words: 72031.0 sentences: 4734.0 pages: flesch: 56.0 cache: ./cache/cord-005646-xhx9pzhj.txt txt: ./txt/cord-005646-xhx9pzhj.txt summary: Aims and methods The aim of both a prospective and retrospective survey conducted in German pediatric intensive care units in 1993 was to accumulate data on the epidemiology, risk factors, natural history and treatment strategies in a large group of pediatric ARDS patients who were treated in the tt~ee year period from 1991 to 1993.All patients had acute bilateral alveolar infiltration of noncardiogenic origin and a pO2~iO2 ratio < 150mmHg. The influence of sex, underlying disease and single organ failure was analyzed using the Fischer''s exact test, the influence of additional organ failure on mortality was tested with the Cochran-Mantel-Haenszet statistics. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095092/ doi: 10.1007/bf02316512 id: cord-005814-ak5pq312 author: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179164.0 sentences: 12028.0 pages: flesch: 56.0 cache: ./cache/cord-005814-ak5pq312.txt txt: ./txt/cord-005814-ak5pq312.txt summary: Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095534/ doi: 10.1007/bf02426401 id: cord-006229-7yoilsho author: nan title: Abstracts of the 82(nd) Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and the 18(th) Annual Meeting of the Network Clinical Pharmacology Germany (VKliPha) in cooperation with the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e.V. (AGAH) date: 2016-02-06 words: 133493.0 sentences: 6804.0 pages: flesch: 42.0 cache: ./cache/cord-006229-7yoilsho.txt txt: ./txt/cord-006229-7yoilsho.txt summary: It directly activates Protein Kinase A (PKA) or the Exchange protein directly activated by cAMP (Epac) which is a guanine exchange factor (GEF) for the small monomeric GTPase Rap. As Human umbilical vein endothelial cells (HUVEC) express both cAMP effectors (Epac1 and PKA), we investigated the role of cAMP-signaling using a spheroid based sprouting assay as an in vitro model for angiogenesis. After activation, S1P receptors regulate important processes in the progression of renal diseases, such as mesangial cell migration Methods and Results: Here we demonstrate that dexamethasone treatment lowered S1P 1 mRNA and protein expression levels in rat mesangial cells measured by TaqMan® and Western blot analyses. The aim of this study was to investigate the relevance of IGFBP5 in cardiogenesis and cardiac remodeling and its role as a potential target for ameliorating stress-induced cardiac remodeling Methods and Results: We investigated the expression of Igfbp5 in murine cardiac tissue at different developmental stages by qPCR normalized to Tpt1 (Tumor Protein, Translationally-Controlled 1). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100641/ doi: 10.1007/s00210-016-1213-y id: cord-006230-xta38e7j author: nan title: Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. date: 2012-02-22 words: 135419.0 sentences: 7042.0 pages: flesch: 43.0 cache: ./cache/cord-006230-xta38e7j.txt txt: ./txt/cord-006230-xta38e7j.txt summary: Here, we will present our analysis of Ca 2+ signaling following stimulation of the FcεRI receptor and application of secretagogues that are supposed to affect Ca 2+ -dependent mast cell activation such as adenosine, endothelin-1, substance P and compound 48/80 in BMMCs and PMCs derived from mouse lines with inactivation of TRPC1, TRPC3, TRPC4, TRPC5 or TRPC6 since specific antagonists are still lacking for these TRP channels. These data indicate that increased PP2A activity is associated with modified gene expression in TG hearts possibly affecting stress response and regulation of cell signalling. As demonstrated by qPCR and Western blot experiments, mesangial cells showed a marked time-and dose-dependent upregulation of CSE mRNA and protein levels after treatment with platelet-derived growth factor (PDGF-BB). The transcription factor cAMP response element (CRE)-binding protein (CREB) plays a critical role in regulating gene expression in response to activation of the cAMPdependent signaling pathway, which is implicated in the pathophysiology of heart failure. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100643/ doi: 10.1007/s00210-012-0736-0 id: cord-006391-esnsa4u5 author: nan title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date: 1982 words: 44844.0 sentences: 2433.0 pages: flesch: 50.0 cache: ./cache/cord-006391-esnsa4u5.txt txt: ./txt/cord-006391-esnsa4u5.txt summary: In our parallel tests using an excision-sample technique [2] which is considerably more sensitive than the DGHM procedure, we have observed the following mean reductions in the counts of accessible bacteria: iodine in ethanol, 96%; povidone-iodine, 89%; chlorhexidine in ethanol, 88%; iso-propanol, The purpose of this study was to compare radiation injury in Guinea Pig small bowel (1) devoid of contents (2) containing bile (3) containing pancreatic juice. Studies in vitro employing isolated perfused rat pancreas and stomach revealed following results: Mean basal pancreatic somatostatin release in normal, diabetic and transplanted rats were 12___3, 24-t-7, and 17__+4 pg/ml, respectively. As these changes appear closely correlated to the blood glucose levels which show a 30 % decrease at 4 h and progressive restoration towards normal values up to 24 h, attempts have been made to alter the insulin/glucagon ratio by glucose infusion after PH and study its relation to liver regeneration. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101735/ doi: 10.1007/bf01279099 id: cord-006860-a3b8hyyr author: nan title: 40th Annual Meeting of the GTH (Gesellschaft für Thrombose- und Hämostaseforschung) date: 1996 words: 90660.0 sentences: 5152.0 pages: flesch: 50.0 cache: ./cache/cord-006860-a3b8hyyr.txt txt: ./txt/cord-006860-a3b8hyyr.txt summary: Dept of Pediatrics, University Hospitals Kiel and Mtinster, Germany Resistance to activated protein C (APCR), in the majority of cases associated with the Arg 506 Gin point mutation in the factor V gene is present in more than 50 % of patients < 60 years of age with unexplained thrombophilia. The regular APC resistance test is not applicable to plasma from Orally anticoagulated (OAC) or heparinized patients due to decreased levels of vitamin K-dependent clotting factors and to thrombin inhibition by antithrombin, respectively. On admission an extensive coagulation screen yielded the following results (n/normal, t/elevated, I/reduced, +/positive, -/negative): PT t, aPTT t, Tr n, factor II, V, VIII n, factor VII, IX, XI, XII /,, fibrinogan t, ATIII n, protein C, S *, activated protein C sensitivity ratio 1.92 ($), FV-Leidenmutation PCR -, fibrinolytic system n, TAT t, Ft÷2 t, lupus anticoagulant +, heparin induced platelet antibodies +; no diagnosis of a specific autoimmuna disorder could be made. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103196/ doi: 10.1007/bf00641048 id: cord-015021-pol2qm74 author: nan title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 words: 162327.0 sentences: 9379.0 pages: flesch: 50.0 cache: ./cache/cord-015021-pol2qm74.txt txt: ./txt/cord-015021-pol2qm74.txt summary: It is our current understanding that LPS is responsible for many of the pathophysiological events observed during gramnegative infections and that one of the major mechanisms leading to shock and death is the LPS-induced activation of macrophages resulting in the production and release of lipid and peptide mediators, among which tumor necrosis factor seems to be the most important. However plasma IL-6 estimation revealed a statistically significant reduction at 6 hours in tanrine-treated animals compared to glycino and TW controls ( Objective: To evaluate the effects of allogeneic blood transfusion, thermal injury and bacterial garage on interteukin 4 (IL-4), tumor necrosis factor alpha (TNF) production and host mortality and to study if the administration of thymopentth (THY) could affect these events. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095072/ doi: 10.1007/bf02258437 id: cord-015024-2xzc0uc5 author: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 words: 84393.0 sentences: 5234.0 pages: flesch: 52.0 cache: ./cache/cord-015024-2xzc0uc5.txt txt: ./txt/cord-015024-2xzc0uc5.txt summary: We performed a prospective clinical study in a 17-bed multidisciplinary intensive care unit, including 21 patients with controlled mechanical ventilation and monitored with the Vigileo Ò monitor, for whom the decision to give fluids was taken due to the presence of circulatory, including arterial hypotension (MAP B 65 mmHg or systolic arterial pressure \90 mmHg), and preserved preload-responsiveness condition, defined as SVV C10%. The aim of this study was to compare and evaluate four severity scoring systems in intensive care unit (ICU), including APACHE II, APACHE III, SASP II and MODS in severe septic patient. A prospective observational study was performed in 16 mechanically ventilated critically ill patients (12 M, age 49 ± 17 yr, BMI 25 ± 5 kg/m 2 , ICU admission day 5 ± 3, APACHE II on study 20 ± 7; mean ± SD) and 6 healthy subjects (3 M, age 24 ± 9 year, BMI 24 ± 45 kg/m 2 ). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095088/ doi: 10.1007/s00134-010-2001-7 id: cord-015082-l629n8is author: nan title: Poster Sessions 323-461 date: 2002-08-29 words: 26569.0 sentences: 1648.0 pages: flesch: 52.0 cache: ./cache/cord-015082-l629n8is.txt txt: ./txt/cord-015082-l629n8is.txt summary: 14 patients awaiting urgent cardiac surgical re-vascularisation were studied with measurement of: spirometry; percentage increase in transfer factor from sitting to lying position (TF) as an indicator of micro-vascular lung disease; overnight oximetry on air; and 24hour holter monitoring Patients, who were reintubated on decreased indices of arterial oxygenation under MOSF progressing died in 100% cases ( NIMV is effective method in complex therapy of ARF, developing in postoperative period after cardiac surgery, that leads to significant improvement of lungs biomechanics and gases change function. In a prospective observational study we performed bedside ptO2 measurements in 8 patients with sepsis/septic shock to gain insight in ptO2 values and their dynamic changes related to the course of the illness, as well as investigating the practical applicability of tissue oxygen measurement in the ICU setting. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095316/ doi: 10.1007/s00134-002-1455-7 id: cord-015090-n6f4xupw author: nan title: PS 339-563 date: 2005-09-10 words: 26280.0 sentences: 1560.0 pages: flesch: 53.0 cache: ./cache/cord-015090-n6f4xupw.txt txt: ./txt/cord-015090-n6f4xupw.txt summary: We designed this study to examine the effects of fiberoptic bronchoscopy (FOB) with and without BAL on body temperature, systemic arterial pressure, heart rate and supportive therapies requirements in mechanically ventilated patients. Clinical characteristics (Glasgow scale, heart rate, systolic blood pressure), cardiac enzymes (troponin I, total serum creatine kinase and myocardial isoenzyme, myoglobin), ECG changes (ST-T changes, prolonged QT and corrected QT intervals), echocardiographic assessment of cardiac function (left ventricular ejection fraction, hypokinesia) were studied on the day of the admission. It is a prospective study performed during 12 months of the patients with brain trauma admitted in a 24-beds medical-surgical ICU of a 650-beds university hospital. This prospective observational study included 200 adult patients admitted to a 31-bed university hospital medical-surgical ICU during a 3-month period. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095344/ doi: 10.1007/s00134-005-2780-4 id: cord-015147-h0o0yqv8 author: nan title: Oral Communications and Posters date: 2014-09-12 words: 73711.0 sentences: 3862.0 pages: flesch: 43.0 cache: ./cache/cord-015147-h0o0yqv8.txt txt: ./txt/cord-015147-h0o0yqv8.txt summary: Cyclooxygenases (COX) catalyze the first step in the synthesis of prostaglandins (PG) from arachidonic acid.COX-1 is constitutively expressed.The COX-2 gene is an immediate early-response gene that is induced by variety of mitogenic and inflammatory stimuli.Levels of COX-2 are increased in both inflamed and malignant tissues.In inflamed tissues, there is both pharmacological and genetic evidence that targeting COX-2 can either improve (e.g., osteoarthritis) or exacerbate symptoms (e.g., inflammatory bowel disease).Multiple lines of evidence suggest that COX-2 plays a significant role in carcinogenesis.The most specific data that support a cause-and effect relationship between COX-2 and tumorigenesis come from genetic studies.Overexpression of COX-2 has been observed to drive tumor formation whereas COX-2 deficiency protects against several tumor types.Selective COX-2 inhibitors protect against the formation and growth of experimental tumors.Moreover, selective COX-2 inhibitors are active in preventing colorectal adenomas in humans.Increased amounts of COX-2-derived PGE2 are found in both inflamed and neoplastic tissues.The fact that PGE2 can stimulate cell proliferation, inhibit apoptosis and induce angiogenesis fits with evidence that induction of COX-2 contributes to both wound healing and tumor growth.Taken together, it seems likely that COX-2 induction contributes to wound healing in response to injury but reduces the threshold for carcinogenesis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095932/ doi: 10.1007/bf03353884 id: cord-015306-us58wwmp author: nan title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 words: 71194.0 sentences: 4580.0 pages: flesch: 53.0 cache: ./cache/cord-015306-us58wwmp.txt txt: ./txt/cord-015306-us58wwmp.txt summary: The incidence of renal involvement varies from 20 to 60% and there have been some reports showing that nephritis might be related to an older age at onset, persistent purpura (> 1 month), severe abdominal pain, and relapsing disease.Recently, several studies have shown that galactose-deficient IgA1 (Gd-IgA1) is recognized by anti-glycan antibodies, resulting in the formation of the circulating immune complexes and their mesangial deposition causing renal injury in HSP nephritis and serum galactose-deficient IgA1 levels were highly inherited in children with HSP nephritis.Regarding the treatment of HSP, one randomized double-blinded controlled study recently showed that patients with abdiminal pain or arthralgia may benefit from early treatment with prednisone, but the drug has not been proven to be capable of preventing the development of renal symptoms. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101731/ doi: 10.1007/s00467-013-2518-4 id: cord-015372-76xvzvdg author: nan title: National scientific medical meeting 1996 abstracts date: 1996 words: 36596.0 sentences: 2204.0 pages: flesch: 53.0 cache: ./cache/cord-015372-76xvzvdg.txt txt: ./txt/cord-015372-76xvzvdg.txt summary: One, two and five-year survival rates were examined; age at diagnosis and lesion type were extremely significant factors in relation to patient outcome. Patients'' age, sex, risk group, CDC stage, CD4 count, indication for therapy, complication rate and response to treatment are described. Fifty-eight patients (34 male, 24 female) ranging in age from 15 to 65 years (Mean + SD = 28.4 + 10.8) were included in the study. Among these 48 patients (mean age 68.0+12.7), after controlling for age and for the duration and continuity of subsequent antipsychotic treatment, increasing duration of initially untreated psychosis was associated with greater severity of negative symptoms (p<0.005) and with lower scores on the MMSE (p<0.05) but not with executive dysfunction on the EXIT (p=0.3). Conclusion Although not a population based study, care of IDDM in Ireland is almost totally hospital clinic based Cigarette smoking is identified as the major problem to be addressed Patients with diabetes meltitus (DM) are at a higher risk of developing vascular complications, including coronary artery disease (CAD). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103226/ doi: 10.1007/bf02945204 id: cord-015394-uj7fe5y6 author: nan title: Scientific Abstracts date: 2008-12-23 words: 242330.0 sentences: 15267.0 pages: flesch: 52.0 cache: ./cache/cord-015394-uj7fe5y6.txt txt: ./txt/cord-015394-uj7fe5y6.txt summary: Studies involving immunohistochemical analysis of normal ovaries have shown that granulosa cells express significantly higher levels of the activator protein-1 (AP-1) transcription factor, cFos compared to theca cells, where cFos expression is virtually absent. Following acute hypoxia (0.5% O2) for one to six hours, RhoA mRNA, total protein and activation (RhoA-GTP) levels were analysed, using semi-quantitative PCRs and western blot, and compared to normoxic non-pregnant human uterine smooth muscle control cells. Since there is an urgent need for non-invasive methods for determination of fetal (F) and placental (P) function, this study was designed to evaluate the genes differently and commonly expressed in P tissue and leukocytes in maternal (M) and F circulation.Material and Methods. The current study: 1) localized IL-6 mRNA levels in preeclamptic versus normal decidual sections; 2) evaluated mechanisms regulating IL-6 synthesis by targeting intracellular signaling pathways with specific inhibitors; 3) identified potential IL-6 targets by immunolocalizing the IL-6 receptor (IL-6R) to specific cell types in placental bed biopsies. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104449/ doi: 10.1177/19337191080150020102 id: cord-022633-fr55uod6 author: nan title: SAEM Abstracts, Plenary Session date: 2012-04-26 words: 147405.0 sentences: 8927.0 pages: flesch: 54.0 cache: ./cache/cord-022633-fr55uod6.txt txt: ./txt/cord-022633-fr55uod6.txt summary: Staff satisfaction was evaluated through pre/ post-shift and study surveys; administrative data (physician initial assessment (PIA), length of stay (LOS), patients leaving without being seen (LWBS) and against medical advice [LAMA] ) were collected from an electronic, real-time ED information system. Communication Background: The link between extended shift lengths, sleepiness, and occupational injury or illness has been shown, in other health care populations, to be an important and preventable public health concern but heretofore has not been fully described in emergency medical services (EMS Objectives: To assess the effect of an ED-based computer screening and referral intervention for IPV victims and to determine what characteristics resulted in a positive change in their safety. Objectives: Using data from longitudinal surveys by the American Board of Emergency Medicine, the primary objective of this study was to evaluate if resident self-assessments of performance in required competencies improve over the course of graduate medical training and in the years following. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159364/ doi: 10.1111/j.1553-2712.2012.01332.x id: cord-022650-phsr10jp author: nan title: Abstracts TPS date: 2018-08-14 words: 119675.0 sentences: 7010.0 pages: flesch: 55.0 cache: ./cache/cord-022650-phsr10jp.txt txt: ./txt/cord-022650-phsr10jp.txt summary: 0685 | Skin prick test reactivity to aeroallergens in adult allergy clinic in a tertiary hospital: a 12-year retrospective study Results: Five different human sera were screened for specific IgE level against 29 different allergen sources using test methods of three different suppliers. Conclusion: This multicenter prospective study confirmed that stepwise single-dose OFC to egg will help to clarify the severity of egg allergy, and will contribute to improved food allergy manageMethod: The study design was a retrospective cohort study extracting data from the electronic chart of children older than 4 years who visited our out-patient clinic for egg or milk allergy and who underwent an oral food challenge test (OFC) twice within 24 months between November 2013 and December 2017. Results: In the base case analysis, using Italy clinical practice patients with moderate-to severe allergic rhino-conjunctivitis (SS ranging from 6 to 15 points) and a mean age at entry of 21 years, both SCIT and SLIT were associated with increased cost but superior efficacy compared to pharmacotherapy alone. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159469/ doi: 10.1111/all.13539 id: cord-022653-qa1uph35 author: nan title: Poster Discussion Session PDS date: 2017-08-30 words: 58292.0 sentences: 3300.0 pages: flesch: 53.0 cache: ./cache/cord-022653-qa1uph35.txt txt: ./txt/cord-022653-qa1uph35.txt summary: 0206 | G protein coupled receptor kinase 2 (GRK2) regulates endothelial permeability induced by Bradykinin 0208 | Pharmacokinetics (PK) and pharmacodynamics (PD) of c1 esterase inhibitor of chronic urticaria challenges most commonly identified were the following: time of onset of disease; frequency/duration of and provoking factors for wheals; diurnal variation; occurrence in relation to weekends, holidays, and foreign travel; shape, size, and distribution of wheals; associated angioedema; associated subjective symptoms of lesions; family and personal history regarding urticaria, atopy; previous or current allergies, infections, internal diseases, or other possible causes; psychosomatic and psychiatric diseases; surgical implantations and events during surgery; gastric/ intestinal problems; induction by physical agents or exercise; use of drugs; food allergies; relationship to the menstrual cycle; smoking habits; type of work, hobbies; stress; quality of life and emotional impact; previous therapy and response to therapy, and previous diagnostic procedures/results. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159476/ doi: 10.1111/all.13251 id: cord-022940-atbjwpo5 author: nan title: Poster Sessions date: 2016-09-07 words: 241182.0 sentences: 12746.0 pages: flesch: 47.0 cache: ./cache/cord-022940-atbjwpo5.txt txt: ./txt/cord-022940-atbjwpo5.txt summary: We have studied the effect of inhibition of IRE1 (inositol requiring enzyme 1), which is a central mediator of endoplasmic reticulum stress and controls cell proliferation and tumor growth, on hypoxic regulation of the expression of different proliferation related genes in U87 glioma cells. Transient inhibition of Akt and mTOR protein kinase activation in tumor cells followed by reactivation of signaling pathway did not result in a time-dependent difference on EGFR, HER2 and HER3 expression levels. In our study we aimed to determine cytotoxic effect of RES in K562 human CML cell line and to evaluate the expressions of miRNAs that are associated with genetics of leukemia after treatment with RES; to investigate target genes of miRNAs which show significant expression alterations and molecular mechanisms of RES treatment. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164006/ doi: 10.1111/febs.13808 id: cord-023157-0lqlx2rv author: nan title: Poster Sessions date: 2013-04-18 words: 128430.0 sentences: 7726.0 pages: flesch: 55.0 cache: ./cache/cord-023157-0lqlx2rv.txt txt: ./txt/cord-023157-0lqlx2rv.txt summary: The patients revealed the increase of free fatty acids level (2.19 AE 0.10) mmol/l/ml, that meaningfully differed from such indexes in the control group (P < 0.001) and low level of adiponektin (3.70 AE 0.70) mg/ml that confirms their role in development of NAFLD even for persons with normal body weight after the presence of abdominal type of adipose tissue distribution. Results: This study has shown effectiveness in reduction in fasting blood glucose (P < 0.01), systolic blood pressure (P = 0.03), diastolic blood pressure (P = 0.01), weight (P = 0.03), added sugar (P = 0.03) and fat consumption (P < 0.01) while improving physical activity (P < 0.01) and insulin sensitivity (P < 0.01) in the intervention group when compared with the control group at follow up assessment. Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167176/ doi: 10.1111/1753-0407.12032_1 ==== make-pages.sh questions [ERIC WAS HERE] ==== make-pages.sh search /data-disk/reader-compute/reader-cord/bin/make-pages.sh: line 77: /data-disk/reader-compute/reader-cord/tmp/search.htm: No such file or directory Traceback (most recent call last): File "/data-disk/reader-compute/reader-cord/bin/tsv2htm-search.py", line 51, in with open( TEMPLATE, 'r' ) as handle : htm = handle.read() FileNotFoundError: [Errno 2] No such file or directory: '/data-disk/reader-compute/reader-cord/tmp/search.htm' ==== make-pages.sh topic modeling corpus Zipping study carrel