id	sid	tid	token	lemma	pos
cord-016300-vw11c2wt	1	1	key	key	JJ
cord-016300-vw11c2wt	1	2	:	:	:
cord-016300-vw11c2wt	1	3	cord-016300-vw11c2wt	cord-016300-vw11c2wt	NNS
cord-016300-vw11c2wt	1	4	authors	author	NNS
cord-016300-vw11c2wt	1	5	:	:	:
cord-016300-vw11c2wt	1	6	Jain	Jain	NNP
cord-016300-vw11c2wt	1	7	,	,	,
cord-016300-vw11c2wt	1	8	Kewal	Kewal	NNP
cord-016300-vw11c2wt	1	9	K.	K.	NNP
cord-016300-vw11c2wt	1	10	title	title	NN
cord-016300-vw11c2wt	1	11	:	:	:
cord-016300-vw11c2wt	1	12	Biomarkers	biomarker	NNS
cord-016300-vw11c2wt	1	13	of	of	IN
cord-016300-vw11c2wt	1	14	Pulmonary	Pulmonary	NNP
cord-016300-vw11c2wt	1	15	Diseases	Diseases	NNPS
cord-016300-vw11c2wt	1	16	date	date	NN
cord-016300-vw11c2wt	1	17	:	:	:
cord-016300-vw11c2wt	1	18	2017	2017	CD
cord-016300-vw11c2wt	1	19	-	-	HYPH
cord-016300-vw11c2wt	1	20	09	09	CD
cord-016300-vw11c2wt	1	21	-	-	SYM
cord-016300-vw11c2wt	1	22	18	18	CD
cord-016300-vw11c2wt	1	23	journal	journal	NN
cord-016300-vw11c2wt	1	24	:	:	:
cord-016300-vw11c2wt	2	1	The	the	DT
cord-016300-vw11c2wt	2	2	Handbook	Handbook	NNP
cord-016300-vw11c2wt	2	3	of	of	IN
cord-016300-vw11c2wt	2	4	Biomarkers	Biomarkers	NNP
cord-016300-vw11c2wt	2	5	DOI	DOI	NNP
cord-016300-vw11c2wt	2	6	:	:	:
cord-016300-vw11c2wt	2	7	10.1007/978	10.1007/978	CD
cord-016300-vw11c2wt	2	8	-	-	HYPH
cord-016300-vw11c2wt	2	9	1	1	CD
cord-016300-vw11c2wt	2	10	-	-	HYPH
cord-016300-vw11c2wt	2	11	4939	4939	CD
cord-016300-vw11c2wt	2	12	-	-	HYPH
cord-016300-vw11c2wt	2	13	7431	7431	CD
cord-016300-vw11c2wt	2	14	-	-	HYPH
cord-016300-vw11c2wt	2	15	3_16	3_16	CD
cord-016300-vw11c2wt	2	16	sha	sha	NNP
cord-016300-vw11c2wt	2	17	:	:	:
cord-016300-vw11c2wt	3	1	73831976e8ab225d53c1e214d0a1ef2b6e63d8cd	73831976e8ab225d53c1e214d0a1ef2b6e63d8cd	CD
cord-016300-vw11c2wt	3	2	doc_id	doc_id	CD
cord-016300-vw11c2wt	3	3	:	:	:
cord-016300-vw11c2wt	4	1	16300	16300	CD
cord-016300-vw11c2wt	4	2	cord_uid	cord_uid	FW
cord-016300-vw11c2wt	4	3	:	:	:
cord-016300-vw11c2wt	5	1	vw11c2wt	vw11c2wt	NN
cord-016300-vw11c2wt	6	1	Lungs	lung	NNS
cord-016300-vw11c2wt	6	2	and	and	CC
cord-016300-vw11c2wt	6	3	airways	airway	NNS
cord-016300-vw11c2wt	6	4	are	be	VBP
cord-016300-vw11c2wt	6	5	affected	affect	VBN
cord-016300-vw11c2wt	6	6	by	by	IN
cord-016300-vw11c2wt	6	7	several	several	JJ
cord-016300-vw11c2wt	6	8	pathologies	pathology	NNS
cord-016300-vw11c2wt	6	9	,	,	,
cord-016300-vw11c2wt	6	10	the	the	DT
cord-016300-vw11c2wt	6	11	most	most	RBS
cord-016300-vw11c2wt	6	12	important	important	JJ
cord-016300-vw11c2wt	6	13	of	of	IN
cord-016300-vw11c2wt	6	14	which	which	WDT
cord-016300-vw11c2wt	6	15	are	be	VBP
cord-016300-vw11c2wt	6	16	inflammation	inflammation	NN
cord-016300-vw11c2wt	6	17	,	,	,
cord-016300-vw11c2wt	6	18	infection	infection	NN
cord-016300-vw11c2wt	6	19	and	and	CC
cord-016300-vw11c2wt	6	20	cancer	cancer	NN
cord-016300-vw11c2wt	6	21	.	.	.
cord-016300-vw11c2wt	7	1	Some	some	DT
cord-016300-vw11c2wt	7	2	of	of	IN
cord-016300-vw11c2wt	7	3	the	the	DT
cord-016300-vw11c2wt	7	4	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	7	5	of	of	IN
cord-016300-vw11c2wt	7	6	these	these	DT
cord-016300-vw11c2wt	7	7	pathologies	pathology	NNS
cord-016300-vw11c2wt	7	8	are	be	VBP
cord-016300-vw11c2wt	7	9	similar	similar	JJ
cord-016300-vw11c2wt	7	10	to	to	IN
cord-016300-vw11c2wt	7	11	those	those	DT
cord-016300-vw11c2wt	7	12	found	find	VBN
cord-016300-vw11c2wt	7	13	in	in	IN
cord-016300-vw11c2wt	7	14	involvement	involvement	NN
cord-016300-vw11c2wt	7	15	of	of	IN
cord-016300-vw11c2wt	7	16	other	other	JJ
cord-016300-vw11c2wt	7	17	organs	organ	NNS
cord-016300-vw11c2wt	7	18	.	.	.
cord-016300-vw11c2wt	8	1	This	this	DT
cord-016300-vw11c2wt	8	2	chapter	chapter	NN
cord-016300-vw11c2wt	8	3	will	will	MD
cord-016300-vw11c2wt	8	4	briefly	briefly	RB
cord-016300-vw11c2wt	8	5	discuss	discuss	VB
cord-016300-vw11c2wt	8	6	general	general	JJ
cord-016300-vw11c2wt	8	7	issues	issue	NNS
cord-016300-vw11c2wt	8	8	of	of	IN
cord-016300-vw11c2wt	8	9	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	8	10	of	of	IN
cord-016300-vw11c2wt	8	11	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	8	12	disorders	disorder	NNS
cord-016300-vw11c2wt	8	13	listed	list	VBN
cord-016300-vw11c2wt	8	14	in	in	IN
cord-016300-vw11c2wt	8	15	Table	Table	NNP
cord-016300-vw11c2wt	8	16	16.1	16.1	CD
cord-016300-vw11c2wt	8	17	.	.	.
cord-016300-vw11c2wt	9	1	Biomarkers	biomarker	NNS
cord-016300-vw11c2wt	9	2	of	of	IN
cord-016300-vw11c2wt	9	3	lung	lung	NN
cord-016300-vw11c2wt	9	4	cancer	cancer	NN
cord-016300-vw11c2wt	9	5	are	be	VBP
cord-016300-vw11c2wt	9	6	described	describe	VBN
cord-016300-vw11c2wt	9	7	in	in	IN
cord-016300-vw11c2wt	9	8	Chapter	chapter	NN
cord-016300-vw11c2wt	9	9	13	13	CD
cord-016300-vw11c2wt	9	10	.	.	.
cord-016300-vw11c2wt	10	1	Lungs	lung	NNS
cord-016300-vw11c2wt	10	2	and	and	CC
cord-016300-vw11c2wt	10	3	airways	airway	NNS
cord-016300-vw11c2wt	10	4	are	be	VBP
cord-016300-vw11c2wt	10	5	affected	affect	VBN
cord-016300-vw11c2wt	10	6	by	by	IN
cord-016300-vw11c2wt	10	7	several	several	JJ
cord-016300-vw11c2wt	10	8	pathologies	pathology	NNS
cord-016300-vw11c2wt	10	9	,	,	,
cord-016300-vw11c2wt	10	10	the	the	DT
cord-016300-vw11c2wt	10	11	most	most	RBS
cord-016300-vw11c2wt	10	12	important	important	JJ
cord-016300-vw11c2wt	10	13	of	of	IN
cord-016300-vw11c2wt	10	14	which	which	WDT
cord-016300-vw11c2wt	10	15	are	be	VBP
cord-016300-vw11c2wt	10	16	inflammation	inflammation	NN
cord-016300-vw11c2wt	10	17	,	,	,
cord-016300-vw11c2wt	10	18	infection	infection	NN
cord-016300-vw11c2wt	10	19	and	and	CC
cord-016300-vw11c2wt	10	20	cancer	cancer	NN
cord-016300-vw11c2wt	10	21	.	.	.
cord-016300-vw11c2wt	11	1	Some	some	DT
cord-016300-vw11c2wt	11	2	of	of	IN
cord-016300-vw11c2wt	11	3	the	the	DT
cord-016300-vw11c2wt	11	4	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	11	5	of	of	IN
cord-016300-vw11c2wt	11	6	these	these	DT
cord-016300-vw11c2wt	11	7	pathologies	pathology	NNS
cord-016300-vw11c2wt	11	8	are	be	VBP
cord-016300-vw11c2wt	11	9	similar	similar	JJ
cord-016300-vw11c2wt	11	10	to	to	IN
cord-016300-vw11c2wt	11	11	those	those	DT
cord-016300-vw11c2wt	11	12	found	find	VBN
cord-016300-vw11c2wt	11	13	in	in	IN
cord-016300-vw11c2wt	11	14	involvement	involvement	NN
cord-016300-vw11c2wt	11	15	of	of	IN
cord-016300-vw11c2wt	11	16	other	other	JJ
cord-016300-vw11c2wt	11	17	organs	organ	NNS
cord-016300-vw11c2wt	11	18	.	.	.
cord-016300-vw11c2wt	12	1	This	this	DT
cord-016300-vw11c2wt	12	2	chapter	chapter	NN
cord-016300-vw11c2wt	12	3	will	will	MD
cord-016300-vw11c2wt	12	4	briefly	briefly	RB
cord-016300-vw11c2wt	12	5	discuss	discuss	VB
cord-016300-vw11c2wt	12	6	general	general	JJ
cord-016300-vw11c2wt	12	7	issues	issue	NNS
cord-016300-vw11c2wt	12	8	of	of	IN
cord-016300-vw11c2wt	12	9	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	12	10	of	of	IN
cord-016300-vw11c2wt	12	11	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	12	12	disorders	disorder	NNS
cord-016300-vw11c2wt	12	13	listed	list	VBN
cord-016300-vw11c2wt	12	14	in	in	IN
cord-016300-vw11c2wt	12	15	Table	Table	NNP
cord-016300-vw11c2wt	12	16	16	16	CD
cord-016300-vw11c2wt	12	17	.1	.1	NN
cord-016300-vw11c2wt	12	18	.	.	.
cord-016300-vw11c2wt	13	1	Biomarkers	biomarker	NNS
cord-016300-vw11c2wt	13	2	of	of	IN
cord-016300-vw11c2wt	13	3	lung	lung	NN
cord-016300-vw11c2wt	13	4	cancer	cancer	NN
cord-016300-vw11c2wt	13	5	are	be	VBP
cord-016300-vw11c2wt	13	6	described	describe	VBN
cord-016300-vw11c2wt	13	7	in	in	IN
cord-016300-vw11c2wt	13	8	Chapter	chapter	NN
cord-016300-vw11c2wt	13	9	13	13	CD
cord-016300-vw11c2wt	13	10	.	.	.
cord-016300-vw11c2wt	14	1	Low	low	JJ
cord-016300-vw11c2wt	14	2	lung	lung	NN
cord-016300-vw11c2wt	14	3	function	function	NN
cord-016300-vw11c2wt	14	4	is	be	VBZ
cord-016300-vw11c2wt	14	5	associated	associate	VBN
cord-016300-vw11c2wt	14	6	with	with	IN
cord-016300-vw11c2wt	14	7	increased	increase	VBN
cord-016300-vw11c2wt	14	8	morbidity	morbidity	NN
cord-016300-vw11c2wt	14	9	and	and	CC
cord-016300-vw11c2wt	14	10	mortality	mortality	NN
cord-016300-vw11c2wt	14	11	.	.	.
cord-016300-vw11c2wt	15	1	It	-PRON-	PRP
cord-016300-vw11c2wt	15	2	is	be	VBZ
cord-016300-vw11c2wt	15	3	therefore	therefore	RB
cord-016300-vw11c2wt	15	4	of	of	IN
cord-016300-vw11c2wt	15	5	interest	interest	NN
cord-016300-vw11c2wt	15	6	to	to	TO
cord-016300-vw11c2wt	15	7	identify	identify	VB
cord-016300-vw11c2wt	15	8	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	15	9	that	that	WDT
cord-016300-vw11c2wt	15	10	are	be	VBP
cord-016300-vw11c2wt	15	11	associated	associate	VBN
cord-016300-vw11c2wt	15	12	with	with	IN
cord-016300-vw11c2wt	15	13	impaired	impaired	JJ
cord-016300-vw11c2wt	15	14	lung	lung	NN
cord-016300-vw11c2wt	15	15	function	function	NN
cord-016300-vw11c2wt	15	16	.	.	.
cord-016300-vw11c2wt	16	1	Lung	lung	NN
cord-016300-vw11c2wt	16	2	function	function	NN
cord-016300-vw11c2wt	16	3	(	(	-LRB-
cord-016300-vw11c2wt	16	4	FEV1	FEV1	NNP
cord-016300-vw11c2wt	16	5	and	and	CC
cord-016300-vw11c2wt	16	6	FVC	FVC	NNP
cord-016300-vw11c2wt	16	7	)	)	-RRB-
cord-016300-vw11c2wt	16	8	and	and	CC
cord-016300-vw11c2wt	16	9	a	a	DT
cord-016300-vw11c2wt	16	10	panel	panel	NN
cord-016300-vw11c2wt	16	11	of	of	IN
cord-016300-vw11c2wt	16	12	15	15	CD
cord-016300-vw11c2wt	16	13	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	16	14	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	16	15	(	(	-LRB-
cord-016300-vw11c2wt	16	16	including	include	VBG
cord-016300-vw11c2wt	16	17	cytokines	cytokine	NNS
cord-016300-vw11c2wt	16	18	,	,	,
cord-016300-vw11c2wt	16	19	chemokines	chemokine	NNS
cord-016300-vw11c2wt	16	20	,	,	,
cord-016300-vw11c2wt	16	21	adhesion	adhesion	NN
cord-016300-vw11c2wt	16	22	molecules	molecule	NNS
cord-016300-vw11c2wt	16	23	,	,	,
cord-016300-vw11c2wt	16	24	CRP	CRP	NNP
cord-016300-vw11c2wt	16	25	and	and	CC
cord-016300-vw11c2wt	16	26	WBC	WBC	NNP
cord-016300-vw11c2wt	16	27	count	count	NN
cord-016300-vw11c2wt	16	28	)	)	-RRB-
cord-016300-vw11c2wt	16	29	from	from	IN
cord-016300-vw11c2wt	16	30	blood	blood	NN
cord-016300-vw11c2wt	16	31	samples	sample	NNS
cord-016300-vw11c2wt	16	32	were	be	VBD
cord-016300-vw11c2wt	16	33	analysed	analyse	VBN
cord-016300-vw11c2wt	16	34	subjects	subject	NNS
cord-016300-vw11c2wt	16	35	aged	age	VBN
cord-016300-vw11c2wt	16	36	70	70	CD
cord-016300-vw11c2wt	16	37	years	year	NNS
cord-016300-vw11c2wt	17	1	(	(	-LRB-
cord-016300-vw11c2wt	17	2	Kuhlmann	Kuhlmann	NNP
cord-016300-vw11c2wt	17	3	et	et	NNP
cord-016300-vw11c2wt	17	4	al	al	NNP
cord-016300-vw11c2wt	17	5	.	.	NNP
cord-016300-vw11c2wt	17	6	2013	2013	CD
cord-016300-vw11c2wt	17	7	)	)	-RRB-
cord-016300-vw11c2wt	17	8	.	.	.
cord-016300-vw11c2wt	18	1	WBC	WBC	NNP
cord-016300-vw11c2wt	18	2	count	count	NN
cord-016300-vw11c2wt	18	3	,	,	,
cord-016300-vw11c2wt	18	4	CRP	CRP	NNP
cord-016300-vw11c2wt	18	5	and	and	CC
cord-016300-vw11c2wt	18	6	VCAM-1	VCAM-1	NNP
cord-016300-vw11c2wt	18	7	were	be	VBD
cord-016300-vw11c2wt	18	8	found	find	VBN
cord-016300-vw11c2wt	18	9	to	to	TO
cord-016300-vw11c2wt	18	10	relate	relate	VB
cord-016300-vw11c2wt	18	11	to	to	IN
cord-016300-vw11c2wt	18	12	poorer	poor	JJR
cord-016300-vw11c2wt	18	13	lung	lung	NN
cord-016300-vw11c2wt	18	14	function	function	NN
cord-016300-vw11c2wt	18	15	.	.	.
cord-016300-vw11c2wt	19	1	A	a	DT
cord-016300-vw11c2wt	19	2	doserelated	doserelated	JJ
cord-016300-vw11c2wt	19	3	association	association	NN
cord-016300-vw11c2wt	19	4	was	be	VBD
cord-016300-vw11c2wt	19	5	found	find	VBN
cord-016300-vw11c2wt	19	6	for	for	IN
cord-016300-vw11c2wt	19	7	the	the	DT
cord-016300-vw11c2wt	19	8	combination	combination	NN
cord-016300-vw11c2wt	19	9	WBC	WBC	NNP
cord-016300-vw11c2wt	19	10	count	count	NN
cord-016300-vw11c2wt	19	11	and	and	CC
cord-016300-vw11c2wt	19	12	CRP	CRP	NNP
cord-016300-vw11c2wt	19	13	towards	towards	IN
cord-016300-vw11c2wt	19	14	FEV1	FEV1	NNP
cord-016300-vw11c2wt	19	15	and	and	CC
cord-016300-vw11c2wt	19	16	WBC	WBC	NNP
cord-016300-vw11c2wt	19	17	and	and	CC
cord-016300-vw11c2wt	19	18	VCAM-1	VCAM-1	NNP
cord-016300-vw11c2wt	19	19	towards	towards	IN
cord-016300-vw11c2wt	19	20	FVC	FVC	NNP
cord-016300-vw11c2wt	19	21	.	.	.
cord-016300-vw11c2wt	20	1	This	this	DT
cord-016300-vw11c2wt	20	2	indicates	indicate	VBZ
cord-016300-vw11c2wt	20	3	that	that	IN
cord-016300-vw11c2wt	20	4	combination	combination	NN
cord-016300-vw11c2wt	20	5	of	of	IN
cord-016300-vw11c2wt	20	6	two	two	CD
cord-016300-vw11c2wt	20	7	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	20	8	yielded	yield	VBD
cord-016300-vw11c2wt	20	9	more	more	JJR
cord-016300-vw11c2wt	20	10	information	information	NN
cord-016300-vw11c2wt	20	11	than	than	IN
cord-016300-vw11c2wt	20	12	assessing	assess	VBG
cord-016300-vw11c2wt	20	13	them	-PRON-	PRP
cord-016300-vw11c2wt	20	14	one	one	CD
cord-016300-vw11c2wt	20	15	by	by	IN
cord-016300-vw11c2wt	20	16	one	one	CD
cord-016300-vw11c2wt	20	17	when	when	WRB
cord-016300-vw11c2wt	20	18	analysing	analyse	VBG
cord-016300-vw11c2wt	20	19	the	the	DT
cord-016300-vw11c2wt	20	20	association	association	NN
cord-016300-vw11c2wt	20	21	between	between	IN
cord-016300-vw11c2wt	20	22	systemic	systemic	JJ
cord-016300-vw11c2wt	20	23	inflammation	inflammation	NN
cord-016300-vw11c2wt	20	24	and	and	CC
cord-016300-vw11c2wt	20	25	lung	lung	NN
cord-016300-vw11c2wt	20	26	function	function	NN
cord-016300-vw11c2wt	20	27	.	.	.
cord-016300-vw11c2wt	20	28	 	 	_SP
cord-016300-vw11c2wt	21	1	Oxidative	oxidative	JJ
cord-016300-vw11c2wt	21	2	stress	stress	NN
cord-016300-vw11c2wt	21	3	is	be	VBZ
cord-016300-vw11c2wt	21	4	the	the	DT
cord-016300-vw11c2wt	21	5	hallmark	hallmark	NN
cord-016300-vw11c2wt	21	6	of	of	IN
cord-016300-vw11c2wt	21	7	various	various	JJ
cord-016300-vw11c2wt	21	8	chronic	chronic	JJ
cord-016300-vw11c2wt	21	9	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	21	10	lung	lung	NN
cord-016300-vw11c2wt	21	11	diseases	disease	NNS
cord-016300-vw11c2wt	21	12	.	.	.
cord-016300-vw11c2wt	22	1	Increased	increase	VBN
cord-016300-vw11c2wt	22	2	concentrations	concentration	NNS
cord-016300-vw11c2wt	22	3	of	of	IN
cord-016300-vw11c2wt	22	4	ROS	ROS	NNP
cord-016300-vw11c2wt	22	5	in	in	IN
cord-016300-vw11c2wt	22	6	the	the	DT
cord-016300-vw11c2wt	22	7	lungs	lung	NNS
cord-016300-vw11c2wt	22	8	of	of	IN
cord-016300-vw11c2wt	22	9	such	such	JJ
cord-016300-vw11c2wt	22	10	patients	patient	NNS
cord-016300-vw11c2wt	22	11	are	be	VBP
cord-016300-vw11c2wt	22	12	reflected	reflect	VBN
cord-016300-vw11c2wt	22	13	by	by	IN
cord-016300-vw11c2wt	22	14	elevated	elevated	JJ
cord-016300-vw11c2wt	22	15	concentrations	concentration	NNS
cord-016300-vw11c2wt	22	16	of	of	IN
cord-016300-vw11c2wt	22	17	oxidative	oxidative	JJ
cord-016300-vw11c2wt	22	18	stress	stress	NN
cord-016300-vw11c2wt	22	19	markers	marker	NNS
cord-016300-vw11c2wt	22	20	in	in	IN
cord-016300-vw11c2wt	22	21	the	the	DT
cord-016300-vw11c2wt	22	22	breath	breath	NN
cord-016300-vw11c2wt	22	23	,	,	,
cord-016300-vw11c2wt	22	24	airways	airways	NNP
cord-016300-vw11c2wt	22	25	,	,	,
cord-016300-vw11c2wt	22	26	lung	lung	NN
cord-016300-vw11c2wt	22	27	tissue	tissue	NN
cord-016300-vw11c2wt	22	28	and	and	CC
cord-016300-vw11c2wt	22	29	blood	blood	NN
cord-016300-vw11c2wt	22	30	.	.	.
cord-016300-vw11c2wt	23	1	Traditionally	traditionally	RB
cord-016300-vw11c2wt	23	2	,	,	,
cord-016300-vw11c2wt	23	3	the	the	DT
cord-016300-vw11c2wt	23	4	measurement	measurement	NN
cord-016300-vw11c2wt	23	5	of	of	IN
cord-016300-vw11c2wt	23	6	these	these	DT
cord-016300-vw11c2wt	23	7	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	23	8	has	have	VBZ
cord-016300-vw11c2wt	23	9	involved	involve	VBN
cord-016300-vw11c2wt	23	10	invasive	invasive	JJ
cord-016300-vw11c2wt	23	11	procedures	procedure	NNS
cord-016300-vw11c2wt	23	12	to	to	TO
cord-016300-vw11c2wt	23	13	procure	procure	VB
cord-016300-vw11c2wt	23	14	the	the	DT
cord-016300-vw11c2wt	23	15	samples	sample	NNS
cord-016300-vw11c2wt	23	16	or	or	CC
cord-016300-vw11c2wt	23	17	to	to	TO
cord-016300-vw11c2wt	23	18	examine	examine	VB
cord-016300-vw11c2wt	23	19	the	the	DT
cord-016300-vw11c2wt	23	20	affected	affected	JJ
cord-016300-vw11c2wt	23	21	compartments	compartment	NNS
cord-016300-vw11c2wt	23	22	,	,	,
cord-016300-vw11c2wt	23	23	to	to	IN
cord-016300-vw11c2wt	23	24	the	the	DT
cord-016300-vw11c2wt	23	25	patient	patient	NN
cord-016300-vw11c2wt	23	26	's	's	POS
cord-016300-vw11c2wt	23	27	discomfort	discomfort	NN
cord-016300-vw11c2wt	23	28	.	.	.
cord-016300-vw11c2wt	24	1	Non	non	JJ
cord-016300-vw11c2wt	24	2	-	-	JJ
cord-016300-vw11c2wt	24	3	invasive	invasive	JJ
cord-016300-vw11c2wt	24	4	approaches	approach	NNS
cord-016300-vw11c2wt	24	5	to	to	TO
cord-016300-vw11c2wt	24	6	measure	measure	VB
cord-016300-vw11c2wt	24	7	oxidative	oxidative	JJ
cord-016300-vw11c2wt	24	8	stress	stress	NN
cord-016300-vw11c2wt	24	9	have	have	VBP
cord-016300-vw11c2wt	24	10	been	be	VBN
cord-016300-vw11c2wt	24	11	investigated	investigate	VBN
cord-016300-vw11c2wt	24	12	.	.	.
cord-016300-vw11c2wt	25	1	The	the	DT
cord-016300-vw11c2wt	25	2	collection	collection	NN
cord-016300-vw11c2wt	25	3	of	of	IN
cord-016300-vw11c2wt	25	4	exhaled	exhale	VBN
cord-016300-vw11c2wt	25	5	breath	breath	NN
cord-016300-vw11c2wt	25	6	condensate	condensate	NN
cord-016300-vw11c2wt	25	7	(	(	-LRB-
cord-016300-vw11c2wt	25	8	EBC	EBC	NNP
cord-016300-vw11c2wt	25	9	)	)	-RRB-
cord-016300-vw11c2wt	25	10	is	be	VBZ
cord-016300-vw11c2wt	25	11	a	a	DT
cord-016300-vw11c2wt	25	12	noninvasive	noninvasive	JJ
cord-016300-vw11c2wt	25	13	sampling	sampling	NN
cord-016300-vw11c2wt	25	14	method	method	NN
cord-016300-vw11c2wt	25	15	for	for	IN
cord-016300-vw11c2wt	25	16	real	real	JJ
cord-016300-vw11c2wt	25	17	-	-	HYPH
cord-016300-vw11c2wt	25	18	time	time	NN
cord-016300-vw11c2wt	25	19	analysis	analysis	NN
cord-016300-vw11c2wt	25	20	and	and	CC
cord-016300-vw11c2wt	25	21	evaluation	evaluation	NN
cord-016300-vw11c2wt	25	22	of	of	IN
cord-016300-vw11c2wt	25	23	oxidative	oxidative	JJ
cord-016300-vw11c2wt	25	24	stress	stress	NN
cord-016300-vw11c2wt	25	25	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	25	26	in	in	IN
cord-016300-vw11c2wt	25	27	the	the	DT
cord-016300-vw11c2wt	25	28	lower	low	JJR
cord-016300-vw11c2wt	25	29	respiratory	respiratory	JJ
cord-016300-vw11c2wt	25	30	tract	tract	NN
cord-016300-vw11c2wt	25	31	airways	airway	NNS
cord-016300-vw11c2wt	25	32	.	.	.
cord-016300-vw11c2wt	26	1	The	the	DT
cord-016300-vw11c2wt	26	2	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	26	3	of	of	IN
cord-016300-vw11c2wt	26	4	oxidative	oxidative	JJ
cord-016300-vw11c2wt	26	5	stress	stress	NN
cord-016300-vw11c2wt	26	6	such	such	JJ
cord-016300-vw11c2wt	26	7	as	as	IN
cord-016300-vw11c2wt	26	8	H	H	NNP
cord-016300-vw11c2wt	26	9	2	2	CD
cord-016300-vw11c2wt	26	10	O	o	NN
cord-016300-vw11c2wt	26	11	2	2	CD
cord-016300-vw11c2wt	26	12	,	,	,
cord-016300-vw11c2wt	26	13	F2-isoprostanes	F2-isoprostanes	NNPS
cord-016300-vw11c2wt	26	14	,	,	,
cord-016300-vw11c2wt	26	15	malondialdehyde	malondialdehyde	NNP
cord-016300-vw11c2wt	26	16	,	,	,
cord-016300-vw11c2wt	26	17	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal	CD
cord-016300-vw11c2wt	26	18	,	,	,
cord-016300-vw11c2wt	26	19	antioxidants	antioxidant	NNS
cord-016300-vw11c2wt	26	20	,	,	,
cord-016300-vw11c2wt	26	21	glutathione	glutathione	NN
cord-016300-vw11c2wt	26	22	and	and	CC
cord-016300-vw11c2wt	26	23	nitrosative	nitrosative	JJ
cord-016300-vw11c2wt	26	24	stress	stress	NN
cord-016300-vw11c2wt	26	25	such	such	JJ
cord-016300-vw11c2wt	26	26	as	as	IN
cord-016300-vw11c2wt	26	27	nitrate	nitrate	NN
cord-016300-vw11c2wt	26	28	/	/	SYM
cord-016300-vw11c2wt	26	29	nitrite	nitrite	NN
cord-016300-vw11c2wt	26	30	and	and	CC
cord-016300-vw11c2wt	26	31	nitrosated	nitrosate	VBN
cord-016300-vw11c2wt	26	32	species	specie	NNS
cord-016300-vw11c2wt	26	33	can	can	MD
cord-016300-vw11c2wt	26	34	be	be	VB
cord-016300-vw11c2wt	26	35	measured	measure	VBN
cord-016300-vw11c2wt	26	36	in	in	IN
cord-016300-vw11c2wt	26	37	EBC	EBC	NNP
cord-016300-vw11c2wt	26	38	.	.	.
cord-016300-vw11c2wt	27	1	Oxidative	oxidative	JJ
cord-016300-vw11c2wt	27	2	stress	stress	NN
cord-016300-vw11c2wt	27	3	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	27	4	also	also	RB
cord-016300-vw11c2wt	27	5	have	have	VBP
cord-016300-vw11c2wt	27	6	been	be	VBN
cord-016300-vw11c2wt	27	7	measured	measure	VBN
cord-016300-vw11c2wt	27	8	for	for	IN
cord-016300-vw11c2wt	27	9	various	various	JJ
cord-016300-vw11c2wt	27	10	antioxidants	antioxidant	NNS
cord-016300-vw11c2wt	27	11	in	in	IN
cord-016300-vw11c2wt	27	12	disease	disease	NN
cord-016300-vw11c2wt	27	13	prognosis	prognosis	NN
cord-016300-vw11c2wt	27	14	.	.	.
cord-016300-vw11c2wt	28	1	EBC	EBC	NNP
cord-016300-vw11c2wt	28	2	is	be	VBZ
cord-016300-vw11c2wt	28	3	currently	currently	RB
cord-016300-vw11c2wt	28	4	used	use	VBN
cord-016300-vw11c2wt	28	5	as	as	IN
cord-016300-vw11c2wt	28	6	a	a	DT
cord-016300-vw11c2wt	28	7	research	research	NN
cord-016300-vw11c2wt	28	8	and	and	CC
cord-016300-vw11c2wt	28	9	diagnostic	diagnostic	JJ
cord-016300-vw11c2wt	28	10	tool	tool	NN
cord-016300-vw11c2wt	28	11	in	in	IN
cord-016300-vw11c2wt	28	12	free	free	JJ
cord-016300-vw11c2wt	28	13	radical	radical	JJ
cord-016300-vw11c2wt	28	14	research	research	NN
cord-016300-vw11c2wt	28	15	,	,	,
cord-016300-vw11c2wt	28	16	yielding	yield	VBG
cord-016300-vw11c2wt	28	17	information	information	NN
cord-016300-vw11c2wt	28	18	on	on	IN
cord-016300-vw11c2wt	28	19	redox	redox	JJ
cord-016300-vw11c2wt	28	20	disturbance	disturbance	NN
cord-016300-vw11c2wt	28	21	and	and	CC
cord-016300-vw11c2wt	28	22	the	the	DT
cord-016300-vw11c2wt	28	23	degree	degree	NN
cord-016300-vw11c2wt	28	24	and	and	CC
cord-016300-vw11c2wt	28	25	type	type	NN
cord-016300-vw11c2wt	28	26	of	of	IN
cord-016300-vw11c2wt	28	27	inflammation	inflammation	NN
cord-016300-vw11c2wt	28	28	in	in	IN
cord-016300-vw11c2wt	28	29	the	the	DT
cord-016300-vw11c2wt	28	30	lung	lung	NN
cord-016300-vw11c2wt	28	31	.	.	.
cord-016300-vw11c2wt	29	1	It	-PRON-	PRP
cord-016300-vw11c2wt	29	2	is	be	VBZ
cord-016300-vw11c2wt	29	3	expected	expect	VBN
cord-016300-vw11c2wt	29	4	that	that	IN
cord-016300-vw11c2wt	29	5	EBC	EBC	NNP
cord-016300-vw11c2wt	29	6	can	can	MD
cord-016300-vw11c2wt	29	7	be	be	VB
cord-016300-vw11c2wt	29	8	exploited	exploit	VBN
cord-016300-vw11c2wt	29	9	to	to	TO
cord-016300-vw11c2wt	29	10	detect	detect	VB
cord-016300-vw11c2wt	29	11	specific	specific	JJ
cord-016300-vw11c2wt	29	12	levels	level	NNS
cord-016300-vw11c2wt	29	13	of	of	IN
cord-016300-vw11c2wt	29	14	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	29	15	and	and	CC
cord-016300-vw11c2wt	29	16	monitor	monitor	VB
cord-016300-vw11c2wt	29	17	disease	disease	NN
cord-016300-vw11c2wt	29	18	severity	severity	NN
cord-016300-vw11c2wt	29	19	in	in	IN
cord-016300-vw11c2wt	29	20	response	response	NN
cord-016300-vw11c2wt	29	21	to	to	IN
cord-016300-vw11c2wt	29	22	treatment	treatment	NN
cord-016300-vw11c2wt	29	23	.	.	.
cord-016300-vw11c2wt	30	1	Community	community	NN
cord-016300-vw11c2wt	30	2	-	-	HYPH
cord-016300-vw11c2wt	30	3	acquired	acquire	VBN
cord-016300-vw11c2wt	30	4	pneumonia	pneumonia	NN
cord-016300-vw11c2wt	30	5	(	(	-LRB-
cord-016300-vw11c2wt	30	6	CAP	CAP	NNP
cord-016300-vw11c2wt	30	7	)	)	-RRB-
cord-016300-vw11c2wt	30	8	is	be	VBZ
cord-016300-vw11c2wt	30	9	one	one	CD
cord-016300-vw11c2wt	30	10	of	of	IN
cord-016300-vw11c2wt	30	11	the	the	DT
cord-016300-vw11c2wt	30	12	most	most	RBS
cord-016300-vw11c2wt	30	13	common	common	JJ
cord-016300-vw11c2wt	30	14	reasons	reason	NNS
cord-016300-vw11c2wt	30	15	for	for	IN
cord-016300-vw11c2wt	30	16	emergency	emergency	NN
cord-016300-vw11c2wt	30	17	department	department	NN
cord-016300-vw11c2wt	30	18	.	.	.
cord-016300-vw11c2wt	31	1	Despite	despite	IN
cord-016300-vw11c2wt	31	2	its	-PRON-	PRP$
cord-016300-vw11c2wt	31	3	prevalence	prevalence	NN
cord-016300-vw11c2wt	31	4	,	,	,
cord-016300-vw11c2wt	31	5	there	there	EX
cord-016300-vw11c2wt	31	6	are	be	VBP
cord-016300-vw11c2wt	31	7	many	many	JJ
cord-016300-vw11c2wt	31	8	challenges	challenge	NNS
cord-016300-vw11c2wt	31	9	to	to	IN
cord-016300-vw11c2wt	31	10	proper	proper	JJ
cord-016300-vw11c2wt	31	11	diagnosis	diagnosis	NN
cord-016300-vw11c2wt	31	12	and	and	CC
cord-016300-vw11c2wt	31	13	management	management	NN
cord-016300-vw11c2wt	31	14	of	of	IN
cord-016300-vw11c2wt	31	15	pneumonia	pneumonia	NN
cord-016300-vw11c2wt	31	16	.	.	.
cord-016300-vw11c2wt	32	1	There	there	EX
cord-016300-vw11c2wt	32	2	is	be	VBZ
cord-016300-vw11c2wt	32	3	no	no	DT
cord-016300-vw11c2wt	32	4	accurate	accurate	JJ
cord-016300-vw11c2wt	32	5	and	and	CC
cord-016300-vw11c2wt	32	6	timely	timely	JJ
cord-016300-vw11c2wt	32	7	gold	gold	NN
cord-016300-vw11c2wt	32	8	standard	standard	NN
cord-016300-vw11c2wt	32	9	to	to	TO
cord-016300-vw11c2wt	32	10	differentiate	differentiate	VB
cord-016300-vw11c2wt	32	11	bacterial	bacterial	JJ
cord-016300-vw11c2wt	32	12	from	from	IN
cord-016300-vw11c2wt	32	13	viral	viral	JJ
cord-016300-vw11c2wt	32	14	disease	disease	NN
cord-016300-vw11c2wt	32	15	,	,	,
cord-016300-vw11c2wt	32	16	and	and	CC
cord-016300-vw11c2wt	32	17	there	there	EX
cord-016300-vw11c2wt	32	18	are	be	VBP
cord-016300-vw11c2wt	32	19	limitations	limitation	NNS
cord-016300-vw11c2wt	32	20	in	in	IN
cord-016300-vw11c2wt	32	21	precise	precise	JJ
cord-016300-vw11c2wt	32	22	risk	risk	NN
cord-016300-vw11c2wt	32	23	stratification	stratification	NN
cord-016300-vw11c2wt	32	24	of	of	IN
cord-016300-vw11c2wt	32	25	patients	patient	NNS
cord-016300-vw11c2wt	32	26	to	to	TO
cord-016300-vw11c2wt	32	27	ensure	ensure	VB
cord-016300-vw11c2wt	32	28	appropriate	appropriate	JJ
cord-016300-vw11c2wt	32	29	site	site	NN
cord-016300-vw11c2wt	32	30	-	-	HYPH
cord-016300-vw11c2wt	32	31	of	of	IN
cord-016300-vw11c2wt	32	32	-	-	HYPH
cord-016300-vw11c2wt	32	33	care	care	NN
cord-016300-vw11c2wt	32	34	decisions	decision	NNS
cord-016300-vw11c2wt	32	35	.	.	.
cord-016300-vw11c2wt	33	1	Clinical	clinical	JJ
cord-016300-vw11c2wt	33	2	risk	risk	NN
cord-016300-vw11c2wt	33	3	scores	score	NNS
cord-016300-vw11c2wt	33	4	such	such	JJ
cord-016300-vw11c2wt	33	5	as	as	IN
cord-016300-vw11c2wt	33	6	pneumonia	pneumonia	NN
cord-016300-vw11c2wt	33	7	severity	severity	NN
cord-016300-vw11c2wt	33	8	index	index	NN
cord-016300-vw11c2wt	33	9	(	(	-LRB-
cord-016300-vw11c2wt	33	10	PSI	PSI	NNP
cord-016300-vw11c2wt	33	11	)	)	-RRB-
cord-016300-vw11c2wt	33	12	and	and	CC
cord-016300-vw11c2wt	33	13	CURB-65	CURB-65	NNP
cord-016300-vw11c2wt	33	14	(	(	-LRB-
cord-016300-vw11c2wt	33	15	confusion	confusion	NN
cord-016300-vw11c2wt	33	16	,	,	,
cord-016300-vw11c2wt	33	17	urea	urea	NN
cord-016300-vw11c2wt	33	18	,	,	,
cord-016300-vw11c2wt	33	19	respiratory	respiratory	JJ
cord-016300-vw11c2wt	33	20	rate	rate	NN
cord-016300-vw11c2wt	33	21	,	,	,
cord-016300-vw11c2wt	33	22	blood	blood	NN
cord-016300-vw11c2wt	33	23	pressure	pressure	NN
cord-016300-vw11c2wt	33	24	,	,	,
cord-016300-vw11c2wt	33	25	age	age	NN
cord-016300-vw11c2wt	33	26	>	>	XX
cord-016300-vw11c2wt	33	27	65	65	CD
cord-016300-vw11c2wt	33	28	years	year	NNS
cord-016300-vw11c2wt	33	29	)	)	-RRB-
cord-016300-vw11c2wt	33	30	,	,	,
cord-016300-vw11c2wt	33	31	and	and	CC
cord-016300-vw11c2wt	33	32	blood	blood	NN
cord-016300-vw11c2wt	33	33	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	33	34	of	of	IN
cord-016300-vw11c2wt	33	35	different	different	JJ
cord-016300-vw11c2wt	33	36	physiopathological	physiopathological	JJ
cord-016300-vw11c2wt	33	37	pathways	pathway	NNS
cord-016300-vw11c2wt	33	38	are	be	VBP
cord-016300-vw11c2wt	33	39	used	use	VBN
cord-016300-vw11c2wt	33	40	in	in	IN
cord-016300-vw11c2wt	33	41	predicting	predict	VBG
cord-016300-vw11c2wt	33	42	longterm	longterm	JJ
cord-016300-vw11c2wt	33	43	survival	survival	NN
cord-016300-vw11c2wt	33	44	in	in	IN
cord-016300-vw11c2wt	33	45	patients	patient	NNS
cord-016300-vw11c2wt	33	46	with	with	IN
cord-016300-vw11c2wt	33	47	CAP	CAP	NNP
cord-016300-vw11c2wt	33	48	.	.	.
cord-016300-vw11c2wt	34	1	In	in	IN
cord-016300-vw11c2wt	34	2	a	a	DT
cord-016300-vw11c2wt	34	3	prospective	prospective	JJ
cord-016300-vw11c2wt	34	4	study	study	NN
cord-016300-vw11c2wt	34	5	,	,	,
cord-016300-vw11c2wt	34	6	patients	patient	NNS
cord-016300-vw11c2wt	34	7	admitted	admit	VBN
cord-016300-vw11c2wt	34	8	with	with	IN
cord-016300-vw11c2wt	34	9	CAP	CAP	NNP
cord-016300-vw11c2wt	34	10	were	be	VBD
cord-016300-vw11c2wt	34	11	followed	follow	VBN
cord-016300-vw11c2wt	34	12	for	for	IN
cord-016300-vw11c2wt	34	13	6	6	CD
cord-016300-vw11c2wt	34	14	years	year	NNS
cord-016300-vw11c2wt	34	15	and	and	CC
cord-016300-vw11c2wt	34	16	Cox	Cox	NNP
cord-016300-vw11c2wt	34	17	regression	regression	NN
cord-016300-vw11c2wt	34	18	models	model	NNS
cord-016300-vw11c2wt	34	19	as	as	RB
cord-016300-vw11c2wt	34	20	well	well	RB
cord-016300-vw11c2wt	34	21	as	as	IN
cord-016300-vw11c2wt	34	22	area	area	NN
cord-016300-vw11c2wt	34	23	under	under	IN
cord-016300-vw11c2wt	34	24	the	the	DT
cord-016300-vw11c2wt	34	25	receiver	receiver	NN
cord-016300-vw11c2wt	34	26	operating	operate	VBG
cord-016300-vw11c2wt	34	27	characteristics	characteristic	NNS
cord-016300-vw11c2wt	34	28	curve	curve	NN
cord-016300-vw11c2wt	34	29	(	(	-LRB-
cord-016300-vw11c2wt	34	30	AUC	AUC	NNP
cord-016300-vw11c2wt	34	31	)	)	-RRB-
cord-016300-vw11c2wt	34	32	were	be	VBD
cord-016300-vw11c2wt	34	33	used	use	VBN
cord-016300-vw11c2wt	34	34	to	to	TO
cord-016300-vw11c2wt	34	35	investigate	investigate	VB
cord-016300-vw11c2wt	34	36	associations	association	NNS
cord-016300-vw11c2wt	34	37	between	between	IN
cord-016300-vw11c2wt	34	38	initial	initial	JJ
cord-016300-vw11c2wt	34	39	risk	risk	NN
cord-016300-vw11c2wt	34	40	assessment	assessment	NN
cord-016300-vw11c2wt	34	41	and	and	CC
cord-016300-vw11c2wt	34	42	all	all	DT
cord-016300-vw11c2wt	34	43	-	-	HYPH
cord-016300-vw11c2wt	34	44	cause	cause	NN
cord-016300-vw11c2wt	34	45	mortality	mortality	NN
cord-016300-vw11c2wt	35	1	(	(	-LRB-
cord-016300-vw11c2wt	35	2	Alan	Alan	NNP
cord-016300-vw11c2wt	35	3	et	et	NNP
cord-016300-vw11c2wt	35	4	al	al	NNP
cord-016300-vw11c2wt	35	5	.	.	NNP
cord-016300-vw11c2wt	35	6	2015	2015	CD
cord-016300-vw11c2wt	35	7	)	)	-RRB-
cord-016300-vw11c2wt	35	8	.	.	.
cord-016300-vw11c2wt	36	1	Initial	initial	JJ
cord-016300-vw11c2wt	36	2	PSI	PSI	NNP
cord-016300-vw11c2wt	36	3	and	and	CC
cord-016300-vw11c2wt	36	4	CURB-65	curb-65	JJ
cord-016300-vw11c2wt	36	5	scores	score	NNS
cord-016300-vw11c2wt	36	6	both	both	DT
cord-016300-vw11c2wt	36	7	had	have	VBD
cord-016300-vw11c2wt	36	8	excellent	excellent	JJ
cord-016300-vw11c2wt	36	9	long	long	JJ
cord-016300-vw11c2wt	36	10	-	-	HYPH
cord-016300-vw11c2wt	36	11	term	term	NN
cord-016300-vw11c2wt	36	12	prognostic	prognostic	JJ
cord-016300-vw11c2wt	36	13	accuracy	accuracy	NN
cord-016300-vw11c2wt	36	14	,	,	,
cord-016300-vw11c2wt	36	15	with	with	IN
cord-016300-vw11c2wt	36	16	a	a	DT
cord-016300-vw11c2wt	36	17	step	step	NN
cord-016300-vw11c2wt	36	18	-	-	HYPH
cord-016300-vw11c2wt	36	19	wise	wise	JJ
cord-016300-vw11c2wt	36	20	increase	increase	NN
cord-016300-vw11c2wt	36	21	in	in	IN
cord-016300-vw11c2wt	36	22	mortality	mortality	NN
cord-016300-vw11c2wt	36	23	per	per	IN
cord-016300-vw11c2wt	36	24	risk	risk	NN
cord-016300-vw11c2wt	36	25	class	class	NN
cord-016300-vw11c2wt	36	26	.	.	.
cord-016300-vw11c2wt	37	1	The	the	DT
cord-016300-vw11c2wt	37	2	addition	addition	NN
cord-016300-vw11c2wt	37	3	of	of	IN
cord-016300-vw11c2wt	37	4	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	37	5	(	(	-LRB-
cord-016300-vw11c2wt	37	6	pro	pro	JJ
cord-016300-vw11c2wt	37	7	-	-	JJ
cord-016300-vw11c2wt	37	8	adrenomedullin	adrenomedullin	JJ
cord-016300-vw11c2wt	37	9	)	)	-RRB-
cord-016300-vw11c2wt	37	10	and	and	CC
cord-016300-vw11c2wt	37	11	cardiac	cardiac	JJ
cord-016300-vw11c2wt	37	12	(	(	-LRB-
cord-016300-vw11c2wt	37	13	pro	pro	JJ
cord-016300-vw11c2wt	37	14	-	-	JJ
cord-016300-vw11c2wt	37	15	atrial	atrial	JJ
cord-016300-vw11c2wt	37	16	natriuretic	natriuretic	JJ
cord-016300-vw11c2wt	37	17	peptide	peptide	NN
cord-016300-vw11c2wt	37	18	)	)	-RRB-
cord-016300-vw11c2wt	37	19	blood	blood	NN
cord-016300-vw11c2wt	37	20	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	37	21	measured	measure	VBN
cord-016300-vw11c2wt	37	22	upon	upon	IN
cord-016300-vw11c2wt	37	23	hospital	hospital	NN
cord-016300-vw11c2wt	37	24	admission	admission	NN
cord-016300-vw11c2wt	37	25	further	further	RB
cord-016300-vw11c2wt	37	26	improved	improve	VBD
cord-016300-vw11c2wt	37	27	the	the	DT
cord-016300-vw11c2wt	37	28	prognostic	prognostic	JJ
cord-016300-vw11c2wt	37	29	capabilities	capability	NNS
cord-016300-vw11c2wt	37	30	of	of	IN
cord-016300-vw11c2wt	37	31	the	the	DT
cord-016300-vw11c2wt	37	32	PSI	PSI	NNP
cord-016300-vw11c2wt	37	33	.	.	.
cord-016300-vw11c2wt	38	1	Pathological	pathological	JJ
cord-016300-vw11c2wt	38	2	changes	change	NNS
cord-016300-vw11c2wt	38	3	in	in	IN
cord-016300-vw11c2wt	38	4	severe	severe	JJ
cord-016300-vw11c2wt	38	5	acute	acute	JJ
cord-016300-vw11c2wt	38	6	respiratory	respiratory	JJ
cord-016300-vw11c2wt	38	7	syndrome	syndrome	NN
cord-016300-vw11c2wt	38	8	(	(	-LRB-
cord-016300-vw11c2wt	38	9	SARS	SARS	NNP
cord-016300-vw11c2wt	38	10	)	)	-RRB-
cord-016300-vw11c2wt	38	11	suggest	suggest	VBP
cord-016300-vw11c2wt	38	12	that	that	IN
cord-016300-vw11c2wt	38	13	SARS	SARS	NNP
cord-016300-vw11c2wt	38	14	sequelae	sequela	NNS
cord-016300-vw11c2wt	38	15	are	be	VBP
cord-016300-vw11c2wt	38	16	associated	associate	VBN
cord-016300-vw11c2wt	38	17	with	with	IN
cord-016300-vw11c2wt	38	18	dysregulation	dysregulation	NN
cord-016300-vw11c2wt	38	19	of	of	IN
cord-016300-vw11c2wt	38	20	cytokine	cytokine	NN
cord-016300-vw11c2wt	38	21	and	and	CC
cord-016300-vw11c2wt	38	22	chemokine	chemokine	NN
cord-016300-vw11c2wt	38	23	production	production	NN
cord-016300-vw11c2wt	38	24	.	.	.
cord-016300-vw11c2wt	39	1	A	a	DT
cord-016300-vw11c2wt	39	2	study	study	NN
cord-016300-vw11c2wt	39	3	from	from	IN
cord-016300-vw11c2wt	39	4	Taiwan	Taiwan	NNP
cord-016300-vw11c2wt	39	5	showed	show	VBD
cord-016300-vw11c2wt	39	6	that	that	IN
cord-016300-vw11c2wt	39	7	cytokine	cytokine	NN
cord-016300-vw11c2wt	39	8	or	or	CC
cord-016300-vw11c2wt	39	9	chemokine	chemokine	NN
cord-016300-vw11c2wt	39	10	profiles	profile	NNS
cord-016300-vw11c2wt	39	11	in	in	IN
cord-016300-vw11c2wt	39	12	patients	patient	NNS
cord-016300-vw11c2wt	39	13	with	with	IN
cord-016300-vw11c2wt	39	14	SARS	SARS	NNP
cord-016300-vw11c2wt	39	15	differ	differ	VBP
cord-016300-vw11c2wt	39	16	markedly	markedly	RB
cord-016300-vw11c2wt	39	17	from	from	IN
cord-016300-vw11c2wt	39	18	those	those	DT
cord-016300-vw11c2wt	39	19	in	in	IN
cord-016300-vw11c2wt	39	20	patients	patient	NNS
cord-016300-vw11c2wt	39	21	with	with	IN
cord-016300-vw11c2wt	39	22	community	community	NN
cord-016300-vw11c2wt	39	23	-	-	HYPH
cord-016300-vw11c2wt	39	24	acquired	acquire	VBN
cord-016300-vw11c2wt	39	25	pneumonia	pneumonia	NN
cord-016300-vw11c2wt	39	26	(	(	-LRB-
cord-016300-vw11c2wt	39	27	CAP	CAP	NNP
cord-016300-vw11c2wt	39	28	)	)	-RRB-
cord-016300-vw11c2wt	39	29	and	and	CC
cord-016300-vw11c2wt	39	30	control	control	NN
cord-016300-vw11c2wt	39	31	groups	group	NNS
cord-016300-vw11c2wt	40	1	(	(	-LRB-
cord-016300-vw11c2wt	40	2	Chien	Chien	NNP
cord-016300-vw11c2wt	40	3	et	et	FW
cord-016300-vw11c2wt	40	4	al	al	NNP
cord-016300-vw11c2wt	40	5	.	.	.
cord-016300-vw11c2wt	40	6	2006	2006	CD
cord-016300-vw11c2wt	40	7	)	)	-RRB-
cord-016300-vw11c2wt	40	8	.	.	.
cord-016300-vw11c2wt	41	1	Serum	serum	NN
cord-016300-vw11c2wt	41	2	levels	level	NNS
cord-016300-vw11c2wt	41	3	of	of	IN
cord-016300-vw11c2wt	41	4	three	three	CD
cord-016300-vw11c2wt	41	5	cytokines	cytokine	NNS
cord-016300-vw11c2wt	41	6	were	be	VBD
cord-016300-vw11c2wt	41	7	significantly	significantly	RB
cord-016300-vw11c2wt	41	8	elevated	elevate	VBN
cord-016300-vw11c2wt	41	9	in	in	IN
cord-016300-vw11c2wt	41	10	SARS	SARS	NNP
cord-016300-vw11c2wt	41	11	patients	patient	NNS
cord-016300-vw11c2wt	41	12	versus	versus	IN
cord-016300-vw11c2wt	41	13	the	the	DT
cord-016300-vw11c2wt	41	14	CAP	cap	NN
cord-016300-vw11c2wt	41	15	:	:	:
cord-016300-vw11c2wt	42	1	Interferon	interferon	NN
cord-016300-vw11c2wt	42	2	-	-	HYPH
cord-016300-vw11c2wt	42	3	γ	γ	NN
cord-016300-vw11c2wt	42	4	-	-	HYPH
cord-016300-vw11c2wt	42	5	inducible	inducible	JJ
cord-016300-vw11c2wt	42	6	protein-10	protein-10	CD
cord-016300-vw11c2wt	42	7	(	(	-LRB-
cord-016300-vw11c2wt	42	8	IP-10	IP-10	NNP
cord-016300-vw11c2wt	42	9	)	)	-RRB-
cord-016300-vw11c2wt	42	10	,	,	,
cord-016300-vw11c2wt	42	11	interleukin	interleukin	FW
cord-016300-vw11c2wt	42	12	(	(	-LRB-
cord-016300-vw11c2wt	42	13	IL)-2	il)-2	RB
cord-016300-vw11c2wt	42	14	,	,	,
cord-016300-vw11c2wt	42	15	and	and	CC
cord-016300-vw11c2wt	42	16	IL-6	IL-6	NNP
cord-016300-vw11c2wt	42	17	.	.	.
cord-016300-vw11c2wt	43	1	Cytokine	cytokine	NN
cord-016300-vw11c2wt	43	2	levels	level	NNS
cord-016300-vw11c2wt	43	3	began	begin	VBD
cord-016300-vw11c2wt	43	4	to	to	TO
cord-016300-vw11c2wt	43	5	rise	rise	VB
cord-016300-vw11c2wt	43	6	before	before	IN
cord-016300-vw11c2wt	43	7	the	the	DT
cord-016300-vw11c2wt	43	8	development	development	NN
cord-016300-vw11c2wt	43	9	of	of	IN
cord-016300-vw11c2wt	43	10	chest	chest	NN
cord-016300-vw11c2wt	43	11	involvement	involvement	NN
cord-016300-vw11c2wt	43	12	and	and	CC
cord-016300-vw11c2wt	43	13	peaked	peak	VBD
cord-016300-vw11c2wt	43	14	earlier	early	RBR
cord-016300-vw11c2wt	43	15	than	than	IN
cord-016300-vw11c2wt	43	16	did	do	VBD
cord-016300-vw11c2wt	43	17	lung	lung	NN
cord-016300-vw11c2wt	43	18	injury	injury	NN
cord-016300-vw11c2wt	43	19	assessed	assess	VBN
cord-016300-vw11c2wt	43	20	by	by	IN
cord-016300-vw11c2wt	43	21	chest	chest	NN
cord-016300-vw11c2wt	43	22	x	x	NN
cord-016300-vw11c2wt	43	23	-	-	NN
cord-016300-vw11c2wt	43	24	ray	ray	NN
cord-016300-vw11c2wt	43	25	.	.	.
cord-016300-vw11c2wt	44	1	Conversely	conversely	RB
cord-016300-vw11c2wt	44	2	,	,	,
cord-016300-vw11c2wt	44	3	in	in	IN
cord-016300-vw11c2wt	44	4	CAP	cap	NN
cord-016300-vw11c2wt	44	5	patients	patient	NNS
cord-016300-vw11c2wt	44	6	but	but	CC
cord-016300-vw11c2wt	44	7	not	not	RB
cord-016300-vw11c2wt	44	8	SARS	SARS	NNP
cord-016300-vw11c2wt	44	9	patients	patient	NNS
cord-016300-vw11c2wt	44	10	or	or	CC
cord-016300-vw11c2wt	44	11	controls	control	NNS
cord-016300-vw11c2wt	44	12	,	,	,
cord-016300-vw11c2wt	44	13	levels	level	NNS
cord-016300-vw11c2wt	44	14	of	of	IN
cord-016300-vw11c2wt	44	15	interferon	interferon	NN
cord-016300-vw11c2wt	44	16	-	-	HYPH
cord-016300-vw11c2wt	44	17	γ	γ	NN
cord-016300-vw11c2wt	44	18	,	,	,
cord-016300-vw11c2wt	44	19	IL-10	IL-10	NNP
cord-016300-vw11c2wt	44	20	,	,	,
cord-016300-vw11c2wt	44	21	and	and	CC
cord-016300-vw11c2wt	44	22	IL-8	IL-8	NNP
cord-016300-vw11c2wt	44	23	were	be	VBD
cord-016300-vw11c2wt	44	24	elevated	elevate	VBN
cord-016300-vw11c2wt	44	25	,	,	,
cord-016300-vw11c2wt	44	26	and	and	CC
cord-016300-vw11c2wt	44	27	rose	rise	VBD
cord-016300-vw11c2wt	44	28	in	in	IN
cord-016300-vw11c2wt	44	29	tandem	tandem	NN
cord-016300-vw11c2wt	44	30	with	with	IN
cord-016300-vw11c2wt	44	31	radiographic	radiographic	JJ
cord-016300-vw11c2wt	44	32	changes	change	NNS
cord-016300-vw11c2wt	44	33	.	.	.
cord-016300-vw11c2wt	45	1	A	a	DT
cord-016300-vw11c2wt	45	2	further	further	JJ
cord-016300-vw11c2wt	45	3	difference	difference	NN
cord-016300-vw11c2wt	45	4	between	between	IN
cord-016300-vw11c2wt	45	5	groups	group	NNS
cord-016300-vw11c2wt	45	6	was	be	VBD
cord-016300-vw11c2wt	45	7	the	the	DT
cord-016300-vw11c2wt	45	8	ratio	ratio	NN
cord-016300-vw11c2wt	45	9	of	of	IN
cord-016300-vw11c2wt	45	10	IL-6	IL-6	NNP
cord-016300-vw11c2wt	45	11	to	to	IN
cord-016300-vw11c2wt	45	12	IL-10	IL-10	NNP
cord-016300-vw11c2wt	45	13	,	,	,
cord-016300-vw11c2wt	45	14	at	at	IN
cord-016300-vw11c2wt	45	15	4.84	4.84	CD
cord-016300-vw11c2wt	45	16	in	in	IN
cord-016300-vw11c2wt	45	17	SARS	SARS	NNP
cord-016300-vw11c2wt	45	18	patients	patient	NNS
cord-016300-vw11c2wt	45	19	versus	versus	IN
cord-016300-vw11c2wt	45	20	2.95	2.95	CD
cord-016300-vw11c2wt	45	21	in	in	IN
cord-016300-vw11c2wt	45	22	CAP	CAP	NNP
cord-016300-vw11c2wt	45	23	patients	patient	NNS
cord-016300-vw11c2wt	45	24	.	.	.
cord-016300-vw11c2wt	46	1	However	however	RB
cord-016300-vw11c2wt	46	2	,	,	,
cord-016300-vw11c2wt	46	3	in	in	IN
cord-016300-vw11c2wt	46	4	both	both	DT
cord-016300-vw11c2wt	46	5	sets	set	NNS
cord-016300-vw11c2wt	46	6	of	of	IN
cord-016300-vw11c2wt	46	7	patients	patient	NNS
cord-016300-vw11c2wt	46	8	,	,	,
cord-016300-vw11c2wt	46	9	levels	level	NNS
cord-016300-vw11c2wt	46	10	of	of	IN
cord-016300-vw11c2wt	46	11	IL-6	IL-6	NNP
cord-016300-vw11c2wt	46	12	correlated	correlate	VBD
cord-016300-vw11c2wt	46	13	strongly	strongly	RB
cord-016300-vw11c2wt	46	14	with	with	IN
cord-016300-vw11c2wt	46	15	the	the	DT
cord-016300-vw11c2wt	46	16	severity	severity	NN
cord-016300-vw11c2wt	46	17	of	of	IN
cord-016300-vw11c2wt	46	18	lung	lung	NN
cord-016300-vw11c2wt	46	19	injury	injury	NN
cord-016300-vw11c2wt	46	20	.	.	.
cord-016300-vw11c2wt	47	1	The	the	DT
cord-016300-vw11c2wt	47	2	early	early	JJ
cord-016300-vw11c2wt	47	3	induction	induction	NN
cord-016300-vw11c2wt	47	4	of	of	IN
cord-016300-vw11c2wt	47	5	IP-10	IP-10	NNP
cord-016300-vw11c2wt	47	6	and	and	CC
cord-016300-vw11c2wt	47	7	IL-2	IL-2	NNP
cord-016300-vw11c2wt	47	8	,	,	,
cord-016300-vw11c2wt	47	9	as	as	RB
cord-016300-vw11c2wt	47	10	well	well	RB
cord-016300-vw11c2wt	47	11	as	as	IN
cord-016300-vw11c2wt	47	12	the	the	DT
cord-016300-vw11c2wt	47	13	subsequent	subsequent	JJ
cord-016300-vw11c2wt	47	14	overproduction	overproduction	NN
cord-016300-vw11c2wt	47	15	of	of	IN
cord-016300-vw11c2wt	47	16	IL-6	IL-6	NNP
cord-016300-vw11c2wt	47	17	and	and	CC
cord-016300-vw11c2wt	47	18	lack	lack	NN
cord-016300-vw11c2wt	47	19	of	of	IN
cord-016300-vw11c2wt	47	20	IL-10	IL-10	NNP
cord-016300-vw11c2wt	47	21	,	,	,
cord-016300-vw11c2wt	47	22	probably	probably	RB
cord-016300-vw11c2wt	47	23	contribute	contribute	VB
cord-016300-vw11c2wt	47	24	to	to	IN
cord-016300-vw11c2wt	47	25	the	the	DT
cord-016300-vw11c2wt	47	26	main	main	JJ
cord-016300-vw11c2wt	47	27	immunopathological	immunopathological	JJ
cord-016300-vw11c2wt	47	28	processes	process	NNS
cord-016300-vw11c2wt	47	29	involved	involve	VBN
cord-016300-vw11c2wt	47	30	in	in	IN
cord-016300-vw11c2wt	47	31	SARS	SARS	NNP
cord-016300-vw11c2wt	47	32	lung	lung	NNP
cord-016300-vw11c2wt	47	33	injury	injury	NN
cord-016300-vw11c2wt	47	34	and	and	CC
cord-016300-vw11c2wt	47	35	may	may	MD
cord-016300-vw11c2wt	47	36	be	be	VB
cord-016300-vw11c2wt	47	37	early	early	JJ
cord-016300-vw11c2wt	47	38	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	47	39	of	of	IN
cord-016300-vw11c2wt	47	40	lung	lung	NN
cord-016300-vw11c2wt	47	41	injury	injury	NN
cord-016300-vw11c2wt	47	42	.	.	.
cord-016300-vw11c2wt	48	1	These	these	DT
cord-016300-vw11c2wt	48	2	findings	finding	NNS
cord-016300-vw11c2wt	48	3	differ	differ	VBP
cord-016300-vw11c2wt	48	4	from	from	IN
cord-016300-vw11c2wt	48	5	those	those	DT
cord-016300-vw11c2wt	48	6	observed	observe	VBN
cord-016300-vw11c2wt	48	7	in	in	IN
cord-016300-vw11c2wt	48	8	subjects	subject	NNS
cord-016300-vw11c2wt	48	9	with	with	IN
cord-016300-vw11c2wt	48	10	CAP	CAP	NNP
cord-016300-vw11c2wt	48	11	.	.	.
cord-016300-vw11c2wt	49	1	Plasma	plasma	NN
cord-016300-vw11c2wt	49	2	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	49	3	related	relate	VBN
cord-016300-vw11c2wt	49	4	to	to	IN
cord-016300-vw11c2wt	49	5	inflammation	inflammation	NN
cord-016300-vw11c2wt	49	6	−	−	CD
cord-016300-vw11c2wt	50	1	IL-8	IL-8	NNP
cord-016300-vw11c2wt	50	2	and	and	CC
cord-016300-vw11c2wt	50	3	enhanced	enhanced	JJ
cord-016300-vw11c2wt	50	4	neutrophil	neutrophil	NN
cord-016300-vw11c2wt	50	5	recruitment	recruitment	NN
cord-016300-vw11c2wt	50	6	to	to	IN
cord-016300-vw11c2wt	50	7	the	the	DT
cord-016300-vw11c2wt	50	8	lung	lung	NN
cord-016300-vw11c2wt	50	9	(	(	-LRB-
cord-016300-vw11c2wt	50	10	ICAM-1	ICAM-1	NNP
cord-016300-vw11c2wt	50	11	)	)	-RRB-
cord-016300-vw11c2wt	50	12	−	−	NNP
cord-016300-vw11c2wt	50	13	are	be	VBP
cord-016300-vw11c2wt	50	14	independently	independently	RB
cord-016300-vw11c2wt	50	15	associated	associate	VBN
cord-016300-vw11c2wt	50	16	with	with	IN
cord-016300-vw11c2wt	50	17	increased	increase	VBN
cord-016300-vw11c2wt	50	18	mortality	mortality	NN
cord-016300-vw11c2wt	50	19	in	in	IN
cord-016300-vw11c2wt	50	20	patients	patient	NNS
cord-016300-vw11c2wt	50	21	with	with	IN
cord-016300-vw11c2wt	50	22	ALI	ALI	NNP
cord-016300-vw11c2wt	50	23	.	.	.
cord-016300-vw11c2wt	51	1	Higher	high	JJR
cord-016300-vw11c2wt	51	2	levels	level	NNS
cord-016300-vw11c2wt	51	3	of	of	IN
cord-016300-vw11c2wt	51	4	IL-8	IL-8	NNP
cord-016300-vw11c2wt	51	5	and	and	CC
cord-016300-vw11c2wt	51	6	ICAM-1	ICAM-1	NNP
cord-016300-vw11c2wt	51	7	independently	independently	RB
cord-016300-vw11c2wt	51	8	predicted	predict	VBD
cord-016300-vw11c2wt	51	9	death	death	NN
cord-016300-vw11c2wt	51	10	(	(	-LRB-
cord-016300-vw11c2wt	51	11	McClintock	McClintock	NNP
cord-016300-vw11c2wt	51	12	et	et	NNP
cord-016300-vw11c2wt	51	13	al	al	NNP
cord-016300-vw11c2wt	51	14	.	.	NNP
cord-016300-vw11c2wt	51	15	2008	2008	CD
cord-016300-vw11c2wt	51	16	)	)	-RRB-
cord-016300-vw11c2wt	51	17	.	.	.
cord-016300-vw11c2wt	52	1	In	in	IN
cord-016300-vw11c2wt	52	2	addition	addition	NN
cord-016300-vw11c2wt	52	3	,	,	,
cord-016300-vw11c2wt	52	4	lower	low	JJR
cord-016300-vw11c2wt	52	5	levels	level	NNS
cord-016300-vw11c2wt	52	6	of	of	IN
cord-016300-vw11c2wt	52	7	the	the	DT
cord-016300-vw11c2wt	52	8	coagulation	coagulation	NN
cord-016300-vw11c2wt	52	9	marker	marker	NN
cord-016300-vw11c2wt	52	10	protein	protein	NN
cord-016300-vw11c2wt	52	11	C	C	NNP
cord-016300-vw11c2wt	52	12	were	be	VBD
cord-016300-vw11c2wt	52	13	independently	independently	RB
cord-016300-vw11c2wt	52	14	associated	associate	VBN
cord-016300-vw11c2wt	52	15	with	with	IN
cord-016300-vw11c2wt	52	16	an	an	DT
cord-016300-vw11c2wt	52	17	increased	increase	VBN
cord-016300-vw11c2wt	52	18	risk	risk	NN
cord-016300-vw11c2wt	52	19	of	of	IN
cord-016300-vw11c2wt	52	20	death	death	NN
cord-016300-vw11c2wt	52	21	.	.	.
cord-016300-vw11c2wt	53	1	The	the	DT
cord-016300-vw11c2wt	53	2	association	association	NN
cord-016300-vw11c2wt	53	3	of	of	IN
cord-016300-vw11c2wt	53	4	lower	low	JJR
cord-016300-vw11c2wt	53	5	protein	protein	NN
cord-016300-vw11c2wt	53	6	C	c	NN
cord-016300-vw11c2wt	53	7	levels	level	NNS
cord-016300-vw11c2wt	53	8	with	with	IN
cord-016300-vw11c2wt	53	9	non	non	NNS
cord-016300-vw11c2wt	53	10	-	-	NNS
cord-016300-vw11c2wt	53	11	survivors	survivor	NNS
cord-016300-vw11c2wt	53	12	continues	continue	VBZ
cord-016300-vw11c2wt	53	13	to	to	TO
cord-016300-vw11c2wt	53	14	support	support	VB
cord-016300-vw11c2wt	53	15	the	the	DT
cord-016300-vw11c2wt	53	16	role	role	NN
cord-016300-vw11c2wt	53	17	for	for	IN
cord-016300-vw11c2wt	53	18	disordered	disordered	JJ
cord-016300-vw11c2wt	53	19	coagulation	coagulation	NN
cord-016300-vw11c2wt	53	20	in	in	IN
cord-016300-vw11c2wt	53	21	ALI	ALI	NNP
cord-016300-vw11c2wt	53	22	/	/	SYM
cord-016300-vw11c2wt	53	23	ARDS	ARDS	NNP
cord-016300-vw11c2wt	53	24	.	.	.
cord-016300-vw11c2wt	54	1	These	these	DT
cord-016300-vw11c2wt	54	2	associations	association	NNS
cord-016300-vw11c2wt	54	3	exist	exist	VBP
cord-016300-vw11c2wt	54	4	despite	despite	IN
cord-016300-vw11c2wt	54	5	consistent	consistent	JJ
cord-016300-vw11c2wt	54	6	use	use	NN
cord-016300-vw11c2wt	54	7	of	of	IN
cord-016300-vw11c2wt	54	8	lung	lung	NN
cord-016300-vw11c2wt	54	9	protective	protective	JJ
cord-016300-vw11c2wt	54	10	ventilation	ventilation	NN
cord-016300-vw11c2wt	54	11	and	and	CC
cord-016300-vw11c2wt	54	12	persist	persist	VBP
cord-016300-vw11c2wt	54	13	even	even	RB
cord-016300-vw11c2wt	54	14	when	when	WRB
cord-016300-vw11c2wt	54	15	controlling	control	VBG
cord-016300-vw11c2wt	54	16	for	for	IN
cord-016300-vw11c2wt	54	17	clinical	clinical	JJ
cord-016300-vw11c2wt	54	18	factors	factor	NNS
cord-016300-vw11c2wt	54	19	that	that	WDT
cord-016300-vw11c2wt	54	20	also	also	RB
cord-016300-vw11c2wt	54	21	impact	impact	VBP
cord-016300-vw11c2wt	54	22	upon	upon	IN
cord-016300-vw11c2wt	54	23	outcomes	outcome	NNS
cord-016300-vw11c2wt	54	24	.	.	.
cord-016300-vw11c2wt	55	1	The	the	DT
cord-016300-vw11c2wt	55	2	two	two	CD
cord-016300-vw11c2wt	55	3	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	55	4	with	with	IN
cord-016300-vw11c2wt	55	5	an	an	DT
cord-016300-vw11c2wt	55	6	independent	independent	JJ
cord-016300-vw11c2wt	55	7	association	association	NN
cord-016300-vw11c2wt	55	8	with	with	IN
cord-016300-vw11c2wt	55	9	mortality	mortality	NN
cord-016300-vw11c2wt	55	10	,	,	,
cord-016300-vw11c2wt	55	11	IL-8	IL-8	NNP
cord-016300-vw11c2wt	55	12	and	and	CC
cord-016300-vw11c2wt	55	13	ICAM-1	ICAM-1	NNP
cord-016300-vw11c2wt	55	14	,	,	,
cord-016300-vw11c2wt	55	15	need	need	VBP
cord-016300-vw11c2wt	55	16	to	to	TO
cord-016300-vw11c2wt	55	17	be	be	VB
cord-016300-vw11c2wt	55	18	be	be	VB
cord-016300-vw11c2wt	55	19	studied	study	VBN
cord-016300-vw11c2wt	55	20	further	further	RB
cord-016300-vw11c2wt	55	21	for	for	IN
cord-016300-vw11c2wt	55	22	their	-PRON-	PRP$
cord-016300-vw11c2wt	55	23	potential	potential	JJ
cord-016300-vw11c2wt	55	24	value	value	NN
cord-016300-vw11c2wt	55	25	in	in	IN
cord-016300-vw11c2wt	55	26	stratifying	stratify	VBG
cord-016300-vw11c2wt	55	27	patients	patient	NNS
cord-016300-vw11c2wt	55	28	in	in	IN
cord-016300-vw11c2wt	55	29	clinical	clinical	JJ
cord-016300-vw11c2wt	55	30	trials	trial	NNS
cord-016300-vw11c2wt	55	31	.	.	.
cord-016300-vw11c2wt	56	1	Acute	acute	JJ
cord-016300-vw11c2wt	56	2	respiratory	respiratory	JJ
cord-016300-vw11c2wt	56	3	distress	distress	NN
cord-016300-vw11c2wt	56	4	syndrome	syndrome	NN
cord-016300-vw11c2wt	56	5	(	(	-LRB-
cord-016300-vw11c2wt	56	6	ARDS	ARDS	NNP
cord-016300-vw11c2wt	56	7	)	)	-RRB-
cord-016300-vw11c2wt	56	8	is	be	VBZ
cord-016300-vw11c2wt	56	9	the	the	DT
cord-016300-vw11c2wt	56	10	rapid	rapid	JJ
cord-016300-vw11c2wt	56	11	onset	onset	NN
cord-016300-vw11c2wt	56	12	of	of	IN
cord-016300-vw11c2wt	56	13	respiratory	respiratory	JJ
cord-016300-vw11c2wt	56	14	failure	failure	NN
cord-016300-vw11c2wt	56	15	−	−	CD
cord-016300-vw11c2wt	57	1	the	the	DT
cord-016300-vw11c2wt	57	2	inability	inability	NN
cord-016300-vw11c2wt	57	3	to	to	TO
cord-016300-vw11c2wt	57	4	adequately	adequately	RB
cord-016300-vw11c2wt	57	5	oxygenate	oxygenate	VB
cord-016300-vw11c2wt	57	6	the	the	DT
cord-016300-vw11c2wt	57	7	blood	blood	NN
cord-016300-vw11c2wt	57	8	−	−	NNP
cord-016300-vw11c2wt	57	9	that	that	WDT
cord-016300-vw11c2wt	57	10	often	often	RB
cord-016300-vw11c2wt	57	11	occurs	occur	VBZ
cord-016300-vw11c2wt	57	12	in	in	IN
cord-016300-vw11c2wt	57	13	the	the	DT
cord-016300-vw11c2wt	57	14	critically	critically	RB
cord-016300-vw11c2wt	57	15	ill	ill	JJ
cord-016300-vw11c2wt	57	16	.	.	.
cord-016300-vw11c2wt	58	1	Acute	acute	JJ
cord-016300-vw11c2wt	58	2	lung	lung	NN
cord-016300-vw11c2wt	58	3	injury	injury	NN
cord-016300-vw11c2wt	58	4	(	(	-LRB-
cord-016300-vw11c2wt	58	5	ALI	ALI	NNP
cord-016300-vw11c2wt	58	6	)	)	-RRB-
cord-016300-vw11c2wt	58	7	precedes	precede	VBZ
cord-016300-vw11c2wt	58	8	ARDS	ARDS	NNP
cord-016300-vw11c2wt	58	9	as	as	IN
cord-016300-vw11c2wt	58	10	severe	severe	JJ
cord-016300-vw11c2wt	58	11	respiratory	respiratory	JJ
cord-016300-vw11c2wt	58	12	illnesses	illness	NNS
cord-016300-vw11c2wt	58	13	progress	progress	VBP
cord-016300-vw11c2wt	58	14	.	.	.
cord-016300-vw11c2wt	59	1	Both	both	DT
cord-016300-vw11c2wt	59	2	conditions	condition	NNS
cord-016300-vw11c2wt	59	3	can	can	MD
cord-016300-vw11c2wt	59	4	be	be	VB
cord-016300-vw11c2wt	59	5	life	life	NN
cord-016300-vw11c2wt	59	6	-	-	HYPH
cord-016300-vw11c2wt	59	7	threatening	threaten	VBG
cord-016300-vw11c2wt	59	8	.	.	.
cord-016300-vw11c2wt	60	1	In	in	IN
cord-016300-vw11c2wt	60	2	a	a	DT
cord-016300-vw11c2wt	60	3	large	large	JJ
cord-016300-vw11c2wt	60	4	-	-	HYPH
cord-016300-vw11c2wt	60	5	scale	scale	NN
cord-016300-vw11c2wt	60	6	,	,	,
cord-016300-vw11c2wt	60	7	multicenter	multicenter	JJ
cord-016300-vw11c2wt	60	8	trial	trial	NN
cord-016300-vw11c2wt	60	9	of	of	IN
cord-016300-vw11c2wt	60	10	patients	patient	NNS
cord-016300-vw11c2wt	60	11	with	with	IN
cord-016300-vw11c2wt	60	12	ARDS	ARDS	NNP
cord-016300-vw11c2wt	60	13	or	or	CC
cord-016300-vw11c2wt	60	14	ALI	ALI	NNP
cord-016300-vw11c2wt	60	15	,	,	,
cord-016300-vw11c2wt	60	16	higher	high	JJR
cord-016300-vw11c2wt	60	17	levels	level	NNS
cord-016300-vw11c2wt	60	18	of	of	IN
cord-016300-vw11c2wt	60	19	nitric	nitric	NN
cord-016300-vw11c2wt	60	20	oxide	oxide	NN
cord-016300-vw11c2wt	60	21	(	(	-LRB-
cord-016300-vw11c2wt	60	22	NO	no	UH
cord-016300-vw11c2wt	60	23	)	)	-RRB-
cord-016300-vw11c2wt	60	24	in	in	IN
cord-016300-vw11c2wt	60	25	urine	urine	NN
cord-016300-vw11c2wt	60	26	were	be	VBD
cord-016300-vw11c2wt	60	27	strongly	strongly	RB
cord-016300-vw11c2wt	60	28	associated	associate	VBN
cord-016300-vw11c2wt	60	29	with	with	IN
cord-016300-vw11c2wt	60	30	improved	improved	JJ
cord-016300-vw11c2wt	60	31	survival	survival	NN
cord-016300-vw11c2wt	60	32	,	,	,
cord-016300-vw11c2wt	60	33	more	more	JJR
cord-016300-vw11c2wt	60	34	ventilator	ventilator	NN
cord-016300-vw11c2wt	60	35	-	-	HYPH
cord-016300-vw11c2wt	60	36	free	free	JJ
cord-016300-vw11c2wt	60	37	days	day	NNS
cord-016300-vw11c2wt	60	38	,	,	,
cord-016300-vw11c2wt	60	39	and	and	CC
cord-016300-vw11c2wt	60	40	decreased	decrease	VBD
cord-016300-vw11c2wt	60	41	rates	rate	NNS
cord-016300-vw11c2wt	60	42	of	of	IN
cord-016300-vw11c2wt	60	43	organ	organ	NN
cord-016300-vw11c2wt	60	44	failure	failure	NN
cord-016300-vw11c2wt	60	45	(	(	-LRB-
cord-016300-vw11c2wt	60	46	McClintock	McClintock	NNP
cord-016300-vw11c2wt	60	47	et	et	NNP
cord-016300-vw11c2wt	60	48	al	al	NNP
cord-016300-vw11c2wt	60	49	.	.	NNP
cord-016300-vw11c2wt	60	50	2007	2007	CD
cord-016300-vw11c2wt	60	51	)	)	-RRB-
cord-016300-vw11c2wt	60	52	.	.	.
cord-016300-vw11c2wt	61	1	The	the	DT
cord-016300-vw11c2wt	61	2	authors	author	NNS
cord-016300-vw11c2wt	61	3	speculated	speculate	VBD
cord-016300-vw11c2wt	61	4	that	that	IN
cord-016300-vw11c2wt	61	5	NO	no	DT
cord-016300-vw11c2wt	61	6	has	have	VBZ
cord-016300-vw11c2wt	61	7	a	a	DT
cord-016300-vw11c2wt	61	8	beneficial	beneficial	JJ
cord-016300-vw11c2wt	61	9	effect	effect	NN
cord-016300-vw11c2wt	61	10	on	on	IN
cord-016300-vw11c2wt	61	11	ALI	ALI	NNP
cord-016300-vw11c2wt	61	12	since	since	IN
cord-016300-vw11c2wt	61	13	it	-PRON-	PRP
cord-016300-vw11c2wt	61	14	scavenges	scavenge	VBZ
cord-016300-vw11c2wt	61	15	oxygen	oxygen	NN
cord-016300-vw11c2wt	61	16	free	free	JJ
cord-016300-vw11c2wt	61	17	radicals	radical	NNS
cord-016300-vw11c2wt	61	18	that	that	WDT
cord-016300-vw11c2wt	61	19	are	be	VBP
cord-016300-vw11c2wt	61	20	generated	generate	VBN
cord-016300-vw11c2wt	61	21	during	during	IN
cord-016300-vw11c2wt	61	22	oxidative	oxidative	JJ
cord-016300-vw11c2wt	61	23	stress	stress	NN
cord-016300-vw11c2wt	61	24	.	.	.
cord-016300-vw11c2wt	62	1	Since	since	IN
cord-016300-vw11c2wt	62	2	NO	no	DT
cord-016300-vw11c2wt	62	3	increases	increase	VBZ
cord-016300-vw11c2wt	62	4	microcirculation	microcirculation	NN
cord-016300-vw11c2wt	62	5	,	,	,
cord-016300-vw11c2wt	62	6	it	-PRON-	PRP
cord-016300-vw11c2wt	62	7	helps	help	VBZ
cord-016300-vw11c2wt	62	8	to	to	TO
cord-016300-vw11c2wt	62	9	better	better	RB
cord-016300-vw11c2wt	62	10	perfuse	perfuse	VB
cord-016300-vw11c2wt	62	11	tissue	tissue	NN
cord-016300-vw11c2wt	62	12	beds	bed	NNS
cord-016300-vw11c2wt	62	13	in	in	IN
cord-016300-vw11c2wt	62	14	the	the	DT
cord-016300-vw11c2wt	62	15	lungs	lung	NNS
cord-016300-vw11c2wt	62	16	.	.	.
cord-016300-vw11c2wt	63	1	The	the	DT
cord-016300-vw11c2wt	63	2	investigators	investigator	NNS
cord-016300-vw11c2wt	63	3	offered	offer	VBD
cord-016300-vw11c2wt	63	4	an	an	DT
cord-016300-vw11c2wt	63	5	alternative	alternative	JJ
cord-016300-vw11c2wt	63	6	hypothesis	hypothesis	NN
cord-016300-vw11c2wt	63	7	to	to	TO
cord-016300-vw11c2wt	63	8	explain	explain	VB
cord-016300-vw11c2wt	63	9	their	-PRON-	PRP$
cord-016300-vw11c2wt	63	10	findings	finding	NNS
cord-016300-vw11c2wt	63	11	:	:	:
cord-016300-vw11c2wt	63	12	NO	no	DT
cord-016300-vw11c2wt	63	13	created	create	VBN
cord-016300-vw11c2wt	63	14	inside	inside	IN
cord-016300-vw11c2wt	63	15	the	the	DT
cord-016300-vw11c2wt	63	16	body	body	NN
cord-016300-vw11c2wt	63	17	may	may	MD
cord-016300-vw11c2wt	63	18	have	have	VB
cord-016300-vw11c2wt	63	19	a	a	DT
cord-016300-vw11c2wt	63	20	beneficial	beneficial	JJ
cord-016300-vw11c2wt	63	21	effect	effect	NN
cord-016300-vw11c2wt	63	22	on	on	IN
cord-016300-vw11c2wt	63	23	organs	organ	NNS
cord-016300-vw11c2wt	63	24	other	other	JJ
cord-016300-vw11c2wt	63	25	than	than	IN
cord-016300-vw11c2wt	63	26	the	the	DT
cord-016300-vw11c2wt	63	27	lung	lung	NN
cord-016300-vw11c2wt	63	28	during	during	IN
cord-016300-vw11c2wt	63	29	ALI	ALI	NNP
cord-016300-vw11c2wt	63	30	.	.	.
cord-016300-vw11c2wt	64	1	It	-PRON-	PRP
cord-016300-vw11c2wt	64	2	might	may	MD
cord-016300-vw11c2wt	64	3	help	help	VB
cord-016300-vw11c2wt	64	4	prevent	prevent	VB
cord-016300-vw11c2wt	64	5	further	further	JJ
cord-016300-vw11c2wt	64	6	tissue	tissue	NN
cord-016300-vw11c2wt	64	7	damage	damage	NN
cord-016300-vw11c2wt	64	8	by	by	IN
cord-016300-vw11c2wt	64	9	improving	improve	VBG
cord-016300-vw11c2wt	64	10	oxygen	oxygen	NN
cord-016300-vw11c2wt	64	11	and	and	CC
cord-016300-vw11c2wt	64	12	nutrient	nutrient	NN
cord-016300-vw11c2wt	64	13	delivery	delivery	NN
cord-016300-vw11c2wt	64	14	to	to	IN
cord-016300-vw11c2wt	64	15	the	the	DT
cord-016300-vw11c2wt	64	16	tissues	tissue	NNS
cord-016300-vw11c2wt	64	17	,	,	,
cord-016300-vw11c2wt	64	18	while	while	IN
cord-016300-vw11c2wt	64	19	helping	help	VBG
cord-016300-vw11c2wt	64	20	to	to	TO
cord-016300-vw11c2wt	64	21	decrease	decrease	VB
cord-016300-vw11c2wt	64	22	the	the	DT
cord-016300-vw11c2wt	64	23	amount	amount	NN
cord-016300-vw11c2wt	64	24	of	of	IN
cord-016300-vw11c2wt	64	25	toxic	toxic	JJ
cord-016300-vw11c2wt	64	26	oxygen	oxygen	NN
cord-016300-vw11c2wt	64	27	species	specie	NNS
cord-016300-vw11c2wt	64	28	.	.	.
cord-016300-vw11c2wt	65	1	The	the	DT
cord-016300-vw11c2wt	65	2	authors	author	NNS
cord-016300-vw11c2wt	65	3	also	also	RB
cord-016300-vw11c2wt	65	4	speculated	speculate	VBD
cord-016300-vw11c2wt	65	5	that	that	IN
cord-016300-vw11c2wt	65	6	NO	no	DT
cord-016300-vw11c2wt	65	7	might	may	MD
cord-016300-vw11c2wt	65	8	have	have	VB
cord-016300-vw11c2wt	65	9	antibacterial	antibacterial	JJ
cord-016300-vw11c2wt	65	10	effects	effect	NNS
cord-016300-vw11c2wt	65	11	that	that	WDT
cord-016300-vw11c2wt	65	12	could	could	MD
cord-016300-vw11c2wt	65	13	be	be	VB
cord-016300-vw11c2wt	65	14	important	important	JJ
cord-016300-vw11c2wt	65	15	in	in	IN
cord-016300-vw11c2wt	65	16	infectious	infectious	JJ
cord-016300-vw11c2wt	65	17	conditions	condition	NNS
cord-016300-vw11c2wt	65	18	that	that	WDT
cord-016300-vw11c2wt	65	19	predispose	predispose	VBP
cord-016300-vw11c2wt	65	20	patients	patient	NNS
cord-016300-vw11c2wt	65	21	to	to	IN
cord-016300-vw11c2wt	65	22	ALI	ALI	NNP
cord-016300-vw11c2wt	65	23	.	.	.
cord-016300-vw11c2wt	66	1	Pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	66	2	surfactant	surfactant	NN
cord-016300-vw11c2wt	66	3	,	,	,
cord-016300-vw11c2wt	66	4	a	a	DT
cord-016300-vw11c2wt	66	5	complex	complex	NN
cord-016300-vw11c2wt	66	6	of	of	IN
cord-016300-vw11c2wt	66	7	lipids	lipid	NNS
cord-016300-vw11c2wt	66	8	and	and	CC
cord-016300-vw11c2wt	66	9	proteins	protein	NNS
cord-016300-vw11c2wt	66	10	,	,	,
cord-016300-vw11c2wt	66	11	functions	function	NNS
cord-016300-vw11c2wt	66	12	to	to	TO
cord-016300-vw11c2wt	66	13	keep	keep	VB
cord-016300-vw11c2wt	66	14	alveoli	alveolus	NNS
cord-016300-vw11c2wt	66	15	from	from	IN
cord-016300-vw11c2wt	66	16	collapsing	collapse	VBG
cord-016300-vw11c2wt	66	17	at	at	IN
cord-016300-vw11c2wt	66	18	expiration	expiration	NN
cord-016300-vw11c2wt	66	19	.	.	.
cord-016300-vw11c2wt	67	1	Surfactant	surfactant	NN
cord-016300-vw11c2wt	67	2	proteins	protein	NNS
cord-016300-vw11c2wt	68	1	A	a	DT
cord-016300-vw11c2wt	68	2	(	(	-LRB-
cord-016300-vw11c2wt	68	3	SP	SP	NNP
cord-016300-vw11c2wt	68	4	-	-	HYPH
cord-016300-vw11c2wt	68	5	A	A	NNP
cord-016300-vw11c2wt	68	6	)	)	-RRB-
cord-016300-vw11c2wt	68	7	and	and	CC
cord-016300-vw11c2wt	68	8	D	D	NNP
cord-016300-vw11c2wt	68	9	(	(	-LRB-
cord-016300-vw11c2wt	68	10	SP	SP	NNP
cord-016300-vw11c2wt	68	11	-	-	HYPH
cord-016300-vw11c2wt	68	12	D	D	NNP
cord-016300-vw11c2wt	68	13	)	)	-RRB-
cord-016300-vw11c2wt	68	14	belong	belong	VBP
cord-016300-vw11c2wt	68	15	to	to	IN
cord-016300-vw11c2wt	68	16	the	the	DT
cord-016300-vw11c2wt	68	17	collectin	collectin	NN
cord-016300-vw11c2wt	68	18	family	family	NN
cord-016300-vw11c2wt	68	19	and	and	CC
cord-016300-vw11c2wt	68	20	play	play	VB
cord-016300-vw11c2wt	68	21	pivotal	pivotal	JJ
cord-016300-vw11c2wt	68	22	roles	role	NNS
cord-016300-vw11c2wt	68	23	in	in	IN
cord-016300-vw11c2wt	68	24	the	the	DT
cord-016300-vw11c2wt	68	25	innate	innate	JJ
cord-016300-vw11c2wt	68	26	immunity	immunity	NN
cord-016300-vw11c2wt	68	27	of	of	IN
cord-016300-vw11c2wt	68	28	the	the	DT
cord-016300-vw11c2wt	68	29	lung	lung	NN
cord-016300-vw11c2wt	68	30	.	.	.
cord-016300-vw11c2wt	69	1	Pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	69	2	collectins	collectin	NNS
cord-016300-vw11c2wt	69	3	directly	directly	RB
cord-016300-vw11c2wt	69	4	bind	bind	VBP
cord-016300-vw11c2wt	69	5	with	with	IN
cord-016300-vw11c2wt	69	6	broad	broad	JJ
cord-016300-vw11c2wt	69	7	specificities	specificity	NNS
cord-016300-vw11c2wt	69	8	to	to	IN
cord-016300-vw11c2wt	69	9	a	a	DT
cord-016300-vw11c2wt	69	10	variety	variety	NN
cord-016300-vw11c2wt	69	11	of	of	IN
cord-016300-vw11c2wt	69	12	microorganism	microorganism	NN
cord-016300-vw11c2wt	69	13	and	and	CC
cord-016300-vw11c2wt	69	14	possess	possess	VB
cord-016300-vw11c2wt	69	15	antimicrobial	antimicrobial	JJ
cord-016300-vw11c2wt	69	16	effects	effect	NNS
cord-016300-vw11c2wt	69	17	.	.	.
cord-016300-vw11c2wt	70	1	These	these	DT
cord-016300-vw11c2wt	70	2	proteins	protein	NNS
cord-016300-vw11c2wt	70	3	also	also	RB
cord-016300-vw11c2wt	70	4	exhibit	exhibit	VBP
cord-016300-vw11c2wt	70	5	both	both	DT
cord-016300-vw11c2wt	70	6	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	70	7	and	and	CC
cord-016300-vw11c2wt	70	8	antiinflammatory	antiinflammatory	JJ
cord-016300-vw11c2wt	70	9	functions	function	NNS
cord-016300-vw11c2wt	70	10	.	.	.
cord-016300-vw11c2wt	71	1	The	the	DT
cord-016300-vw11c2wt	71	2	collectins	collectin	NNS
cord-016300-vw11c2wt	71	3	enhance	enhance	VBP
cord-016300-vw11c2wt	71	4	phagocytosis	phagocytosis	NN
cord-016300-vw11c2wt	71	5	of	of	IN
cord-016300-vw11c2wt	71	6	microbes	microbe	NNS
cord-016300-vw11c2wt	71	7	by	by	IN
cord-016300-vw11c2wt	71	8	macrophages	macrophage	NNS
cord-016300-vw11c2wt	71	9	through	through	IN
cord-016300-vw11c2wt	71	10	opsonic	opsonic	NNP
cord-016300-vw11c2wt	71	11	and/or	and/or	CC
cord-016300-vw11c2wt	71	12	non	non	JJ
cord-016300-vw11c2wt	71	13	-	-	JJ
cord-016300-vw11c2wt	71	14	opsonic	opsonic	JJ
cord-016300-vw11c2wt	71	15	activities	activity	NNS
cord-016300-vw11c2wt	71	16	.	.	.
cord-016300-vw11c2wt	72	1	The	the	DT
cord-016300-vw11c2wt	72	2	proteins	protein	NNS
cord-016300-vw11c2wt	72	3	stimulate	stimulate	VBP
cord-016300-vw11c2wt	72	4	cell	cell	NN
cord-016300-vw11c2wt	72	5	surface	surface	NN
cord-016300-vw11c2wt	72	6	expression	expression	NN
cord-016300-vw11c2wt	72	7	of	of	IN
cord-016300-vw11c2wt	72	8	phagocytic	phagocytic	JJ
cord-016300-vw11c2wt	72	9	receptors	receptor	NNS
cord-016300-vw11c2wt	72	10	including	include	VBG
cord-016300-vw11c2wt	72	11	scavenger	scavenger	NN
cord-016300-vw11c2wt	72	12	receptor	receptor	NN
cord-016300-vw11c2wt	72	13	A	a	NN
cord-016300-vw11c2wt	72	14	and	and	CC
cord-016300-vw11c2wt	72	15	mannose	mannose	NN
cord-016300-vw11c2wt	72	16	receptor	receptor	NN
cord-016300-vw11c2wt	72	17	.	.	.
cord-016300-vw11c2wt	73	1	Since	since	IN
cord-016300-vw11c2wt	73	2	the	the	DT
cord-016300-vw11c2wt	73	3	expression	expression	NN
cord-016300-vw11c2wt	73	4	of	of	IN
cord-016300-vw11c2wt	73	5	SP	SP	NNP
cord-016300-vw11c2wt	73	6	-	-	HYPH
cord-016300-vw11c2wt	73	7	A	A	NNP
cord-016300-vw11c2wt	73	8	and	and	CC
cord-016300-vw11c2wt	73	9	SP	SP	NNP
cord-016300-vw11c2wt	73	10	-	-	HYPH
cord-016300-vw11c2wt	73	11	D	D	NNP
cord-016300-vw11c2wt	73	12	is	be	VBZ
cord-016300-vw11c2wt	73	13	abundant	abundant	JJ
cord-016300-vw11c2wt	73	14	and	and	CC
cord-016300-vw11c2wt	73	15	restricted	restrict	VBN
cord-016300-vw11c2wt	73	16	within	within	IN
cord-016300-vw11c2wt	73	17	the	the	DT
cord-016300-vw11c2wt	73	18	lung	lung	NN
cord-016300-vw11c2wt	73	19	,	,	,
cord-016300-vw11c2wt	73	20	the	the	DT
cord-016300-vw11c2wt	73	21	proteins	protein	NNS
cord-016300-vw11c2wt	73	22	are	be	VBP
cord-016300-vw11c2wt	73	23	now	now	RB
cord-016300-vw11c2wt	73	24	clinically	clinically	RB
cord-016300-vw11c2wt	73	25	used	use	VBN
cord-016300-vw11c2wt	73	26	as	as	IN
cord-016300-vw11c2wt	73	27	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	73	28	for	for	IN
cord-016300-vw11c2wt	73	29	lung	lung	NN
cord-016300-vw11c2wt	73	30	diseases	disease	NNS
cord-016300-vw11c2wt	73	31	.	.	.
cord-016300-vw11c2wt	74	1	The	the	DT
cord-016300-vw11c2wt	74	2	levels	level	NNS
cord-016300-vw11c2wt	74	3	of	of	IN
cord-016300-vw11c2wt	74	4	SP	SP	NNP
cord-016300-vw11c2wt	74	5	-	-	HYPH
cord-016300-vw11c2wt	74	6	A	A	NNP
cord-016300-vw11c2wt	74	7	and	and	CC
cord-016300-vw11c2wt	74	8	SP	SP	NNP
cord-016300-vw11c2wt	74	9	-	-	HYPH
cord-016300-vw11c2wt	74	10	D	D	NNP
cord-016300-vw11c2wt	74	11	in	in	IN
cord-016300-vw11c2wt	74	12	bronchoalveolar	bronchoalveolar	JJ
cord-016300-vw11c2wt	74	13	lavage	lavage	NN
cord-016300-vw11c2wt	74	14	fluids	fluid	NNS
cord-016300-vw11c2wt	74	15	,	,	,
cord-016300-vw11c2wt	74	16	amniotic	amniotic	NN
cord-016300-vw11c2wt	74	17	fluids	fluid	NNS
cord-016300-vw11c2wt	74	18	,	,	,
cord-016300-vw11c2wt	74	19	tracheal	tracheal	JJ
cord-016300-vw11c2wt	74	20	aspirates	aspirate	NNS
cord-016300-vw11c2wt	74	21	and	and	CC
cord-016300-vw11c2wt	74	22	pleural	pleural	JJ
cord-016300-vw11c2wt	74	23	effusions	effusion	NNS
cord-016300-vw11c2wt	74	24	reflect	reflect	VBP
cord-016300-vw11c2wt	74	25	alterations	alteration	NNS
cord-016300-vw11c2wt	74	26	in	in	IN
cord-016300-vw11c2wt	74	27	alveolar	alveolar	JJ
cord-016300-vw11c2wt	74	28	compartments	compartment	NNS
cord-016300-vw11c2wt	74	29	and	and	CC
cord-016300-vw11c2wt	74	30	epithelium	epithelium	NN
cord-016300-vw11c2wt	74	31	,	,	,
cord-016300-vw11c2wt	74	32	and	and	CC
cord-016300-vw11c2wt	74	33	lung	lung	NN
cord-016300-vw11c2wt	74	34	maturity	maturity	NN
cord-016300-vw11c2wt	74	35	.	.	.
cord-016300-vw11c2wt	75	1	The	the	DT
cord-016300-vw11c2wt	75	2	determination	determination	NN
cord-016300-vw11c2wt	75	3	of	of	IN
cord-016300-vw11c2wt	75	4	SP	SP	NNP
cord-016300-vw11c2wt	75	5	-	-	HYPH
cord-016300-vw11c2wt	75	6	A	A	NNP
cord-016300-vw11c2wt	75	7	and	and	CC
cord-016300-vw11c2wt	75	8	SP	SP	NNP
cord-016300-vw11c2wt	75	9	-	-	HYPH
cord-016300-vw11c2wt	75	10	D	D	NNP
cord-016300-vw11c2wt	75	11	in	in	IN
cord-016300-vw11c2wt	75	12	sera	sera	NNP
cord-016300-vw11c2wt	75	13	is	be	VBZ
cord-016300-vw11c2wt	75	14	a	a	DT
cord-016300-vw11c2wt	75	15	noninvasive	noninvasive	JJ
cord-016300-vw11c2wt	75	16	and	and	CC
cord-016300-vw11c2wt	75	17	useful	useful	JJ
cord-016300-vw11c2wt	75	18	tool	tool	NN
cord-016300-vw11c2wt	75	19	for	for	IN
cord-016300-vw11c2wt	75	20	understanding	understand	VBG
cord-016300-vw11c2wt	75	21	some	some	DT
cord-016300-vw11c2wt	75	22	pathological	pathological	JJ
cord-016300-vw11c2wt	75	23	changes	change	NNS
cord-016300-vw11c2wt	75	24	of	of	IN
cord-016300-vw11c2wt	75	25	the	the	DT
cord-016300-vw11c2wt	75	26	lung	lung	NN
cord-016300-vw11c2wt	75	27	in	in	IN
cord-016300-vw11c2wt	75	28	the	the	DT
cord-016300-vw11c2wt	75	29	diseases	disease	NNS
cord-016300-vw11c2wt	75	30	,	,	,
cord-016300-vw11c2wt	75	31	including	include	VBG
cord-016300-vw11c2wt	75	32	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	75	33	fibrosis	fibrosis	NN
cord-016300-vw11c2wt	75	34	,	,	,
cord-016300-vw11c2wt	75	35	collagen	collagen	NN
cord-016300-vw11c2wt	75	36	vascular	vascular	JJ
cord-016300-vw11c2wt	75	37	diseases	disease	NNS
cord-016300-vw11c2wt	75	38	complicated	complicate	VBN
cord-016300-vw11c2wt	75	39	with	with	IN
cord-016300-vw11c2wt	75	40	interstitial	interstitial	JJ
cord-016300-vw11c2wt	75	41	lung	lung	NN
cord-016300-vw11c2wt	75	42	disease	disease	NN
cord-016300-vw11c2wt	75	43	,	,	,
cord-016300-vw11c2wt	75	44	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	75	45	alveolar	alveolar	NN
cord-016300-vw11c2wt	75	46	proteinosis	proteinosis	NN
cord-016300-vw11c2wt	75	47	,	,	,
cord-016300-vw11c2wt	75	48	acute	acute	JJ
cord-016300-vw11c2wt	75	49	respiratory	respiratory	JJ
cord-016300-vw11c2wt	75	50	distress	distress	NN
cord-016300-vw11c2wt	75	51	syndrome	syndrome	NN
cord-016300-vw11c2wt	75	52	and	and	CC
cord-016300-vw11c2wt	75	53	radiation	radiation	NN
cord-016300-vw11c2wt	75	54	pneumonitis	pneumonitis	NN
cord-016300-vw11c2wt	75	55	(	(	-LRB-
cord-016300-vw11c2wt	75	56	Takahashi	Takahashi	NNP
cord-016300-vw11c2wt	75	57	et	et	FW
cord-016300-vw11c2wt	75	58	al	al	NNP
cord-016300-vw11c2wt	75	59	.	.	.
cord-016300-vw11c2wt	75	60	2006	2006	CD
cord-016300-vw11c2wt	75	61	)	)	-RRB-
cord-016300-vw11c2wt	75	62	.	.	.
cord-016300-vw11c2wt	76	1	Interstitial	interstitial	JJ
cord-016300-vw11c2wt	76	2	lung	lung	NN
cord-016300-vw11c2wt	76	3	disease	disease	NN
cord-016300-vw11c2wt	76	4	(	(	-LRB-
cord-016300-vw11c2wt	76	5	ILD	ILD	NNP
cord-016300-vw11c2wt	76	6	)	)	-RRB-
cord-016300-vw11c2wt	76	7	is	be	VBZ
cord-016300-vw11c2wt	76	8	defined	define	VBN
cord-016300-vw11c2wt	76	9	as	as	IN
cord-016300-vw11c2wt	76	10	restrictive	restrictive	JJ
cord-016300-vw11c2wt	76	11	lung	lung	NN
cord-016300-vw11c2wt	76	12	function	function	NN
cord-016300-vw11c2wt	76	13	impairment	impairment	NN
cord-016300-vw11c2wt	76	14	with	with	IN
cord-016300-vw11c2wt	76	15	radiographic	radiographic	JJ
cord-016300-vw11c2wt	76	16	signs	sign	NNS
cord-016300-vw11c2wt	76	17	of	of	IN
cord-016300-vw11c2wt	76	18	ILD	ILD	NNP
cord-016300-vw11c2wt	76	19	.	.	.
cord-016300-vw11c2wt	77	1	KL-6	KL-6	NNP
cord-016300-vw11c2wt	77	2	,	,	,
cord-016300-vw11c2wt	77	3	a	a	DT
cord-016300-vw11c2wt	77	4	mucinous	mucinous	JJ
cord-016300-vw11c2wt	77	5	high	high	JJ
cord-016300-vw11c2wt	77	6	-	-	HYPH
cord-016300-vw11c2wt	77	7	molecular	molecular	JJ
cord-016300-vw11c2wt	77	8	weight	weight	NN
cord-016300-vw11c2wt	77	9	glycoprotein	glycoprotein	NN
cord-016300-vw11c2wt	77	10	,	,	,
cord-016300-vw11c2wt	77	11	is	be	VBZ
cord-016300-vw11c2wt	77	12	expressed	express	VBN
cord-016300-vw11c2wt	77	13	on	on	IN
cord-016300-vw11c2wt	77	14	type	type	NN
cord-016300-vw11c2wt	77	15	II	II	NNP
cord-016300-vw11c2wt	77	16	pneumonocytes	pneumonocyte	NNS
cord-016300-vw11c2wt	77	17	and	and	CC
cord-016300-vw11c2wt	77	18	is	be	VBZ
cord-016300-vw11c2wt	77	19	a	a	DT
cord-016300-vw11c2wt	77	20	potential	potential	JJ
cord-016300-vw11c2wt	77	21	biomarker	biomarker	NN
cord-016300-vw11c2wt	77	22	of	of	IN
cord-016300-vw11c2wt	77	23	ILD	ILD	NNP
cord-016300-vw11c2wt	77	24	.	.	.
cord-016300-vw11c2wt	78	1	A	a	DT
cord-016300-vw11c2wt	78	2	retrospective	retrospective	JJ
cord-016300-vw11c2wt	78	3	,	,	,
cord-016300-vw11c2wt	78	4	cross	cross	JJ
cord-016300-vw11c2wt	78	5	-	-	JJ
cord-016300-vw11c2wt	78	6	sectional	sectional	JJ
cord-016300-vw11c2wt	78	7	analysis	analysis	NN
cord-016300-vw11c2wt	78	8	Caucasian	caucasian	JJ
cord-016300-vw11c2wt	78	9	patients	patient	NNS
cord-016300-vw11c2wt	78	10	with	with	IN
cord-016300-vw11c2wt	78	11	polymyositis	polymyositis	NN
cord-016300-vw11c2wt	78	12	(	(	-LRB-
cord-016300-vw11c2wt	78	13	PM	PM	NNP
cord-016300-vw11c2wt	78	14	)	)	-RRB-
cord-016300-vw11c2wt	78	15	or	or	CC
cord-016300-vw11c2wt	78	16	dermatomyositis	dermatomyositis	NNP
cord-016300-vw11c2wt	78	17	(	(	-LRB-
cord-016300-vw11c2wt	78	18	DM	DM	NNP
cord-016300-vw11c2wt	78	19	)	)	-RRB-
cord-016300-vw11c2wt	78	20	and	and	CC
cord-016300-vw11c2wt	78	21	ILD	ILD	NNP
cord-016300-vw11c2wt	78	22	were	be	VBD
cord-016300-vw11c2wt	78	23	shown	show	VBN
cord-016300-vw11c2wt	78	24	to	to	TO
cord-016300-vw11c2wt	78	25	have	have	VB
cord-016300-vw11c2wt	78	26	elevated	elevate	VBN
cord-016300-vw11c2wt	78	27	serum	serum	NN
cord-016300-vw11c2wt	78	28	levels	level	NNS
cord-016300-vw11c2wt	78	29	of	of	IN
cord-016300-vw11c2wt	78	30	KL-6	KL-6	NNP
cord-016300-vw11c2wt	78	31	compared	compare	VBN
cord-016300-vw11c2wt	78	32	to	to	IN
cord-016300-vw11c2wt	78	33	patients	patient	NNS
cord-016300-vw11c2wt	78	34	without	without	IN
cord-016300-vw11c2wt	78	35	ILD	ILD	NNP
cord-016300-vw11c2wt	78	36	(	(	-LRB-
cord-016300-vw11c2wt	78	37	Fathi	Fathi	NNP
cord-016300-vw11c2wt	78	38	et	et	FW
cord-016300-vw11c2wt	78	39	al	al	NNP
cord-016300-vw11c2wt	78	40	.	.	NNP
cord-016300-vw11c2wt	78	41	2012	2012	CD
cord-016300-vw11c2wt	78	42	)	)	-RRB-
cord-016300-vw11c2wt	78	43	.	.	.
cord-016300-vw11c2wt	79	1	At	at	IN
cord-016300-vw11c2wt	79	2	a	a	DT
cord-016300-vw11c2wt	79	3	cut	cut	VB
cord-016300-vw11c2wt	79	4	-	-	HYPH
cord-016300-vw11c2wt	79	5	off	off	RP
cord-016300-vw11c2wt	79	6	level	level	NN
cord-016300-vw11c2wt	79	7	of	of	IN
cord-016300-vw11c2wt	79	8	549	549	CD
cord-016300-vw11c2wt	79	9	U	u	NN
cord-016300-vw11c2wt	79	10	/	/	SYM
cord-016300-vw11c2wt	79	11	ml	ml	XX
cord-016300-vw11c2wt	79	12	,	,	,
cord-016300-vw11c2wt	79	13	the	the	DT
cord-016300-vw11c2wt	79	14	sensitivity	sensitivity	NN
cord-016300-vw11c2wt	79	15	and	and	CC
cord-016300-vw11c2wt	79	16	specificity	specificity	NN
cord-016300-vw11c2wt	79	17	for	for	IN
cord-016300-vw11c2wt	79	18	diagnosis	diagnosis	NN
cord-016300-vw11c2wt	79	19	of	of	IN
cord-016300-vw11c2wt	79	20	ILD	ILD	NNP
cord-016300-vw11c2wt	79	21	was	be	VBD
cord-016300-vw11c2wt	79	22	83	83	CD
cord-016300-vw11c2wt	79	23	%	%	NN
cord-016300-vw11c2wt	79	24	and	and	CC
cord-016300-vw11c2wt	79	25	100	100	CD
cord-016300-vw11c2wt	79	26	%	%	NN
cord-016300-vw11c2wt	79	27	,	,	,
cord-016300-vw11c2wt	79	28	respectively	respectively	RB
cord-016300-vw11c2wt	79	29	.	.	.
cord-016300-vw11c2wt	80	1	The	the	DT
cord-016300-vw11c2wt	80	2	level	level	NN
cord-016300-vw11c2wt	80	3	of	of	IN
cord-016300-vw11c2wt	80	4	serum	serum	NN
cord-016300-vw11c2wt	80	5	KL-6	KL-6	NNP
cord-016300-vw11c2wt	80	6	may	may	MD
cord-016300-vw11c2wt	80	7	serve	serve	VB
cord-016300-vw11c2wt	80	8	as	as	IN
cord-016300-vw11c2wt	80	9	measure	measure	NN
cord-016300-vw11c2wt	80	10	of	of	IN
cord-016300-vw11c2wt	80	11	ILD	ILD	NNP
cord-016300-vw11c2wt	80	12	in	in	IN
cord-016300-vw11c2wt	80	13	patients	patient	NNS
cord-016300-vw11c2wt	80	14	with	with	IN
cord-016300-vw11c2wt	80	15	PM	pm	NN
cord-016300-vw11c2wt	80	16	/	/	SYM
cord-016300-vw11c2wt	80	17	DM	DM	NNP
cord-016300-vw11c2wt	80	18	,	,	,
cord-016300-vw11c2wt	80	19	and	and	CC
cord-016300-vw11c2wt	80	20	is	be	VBZ
cord-016300-vw11c2wt	80	21	a	a	DT
cord-016300-vw11c2wt	80	22	promising	promising	JJ
cord-016300-vw11c2wt	80	23	biomarker	biomarker	NN
cord-016300-vw11c2wt	80	24	for	for	IN
cord-016300-vw11c2wt	80	25	use	use	NN
cord-016300-vw11c2wt	80	26	in	in	IN
cord-016300-vw11c2wt	80	27	clinical	clinical	JJ
cord-016300-vw11c2wt	80	28	practice	practice	NN
cord-016300-vw11c2wt	80	29	to	to	TO
cord-016300-vw11c2wt	80	30	assess	assess	VB
cord-016300-vw11c2wt	80	31	response	response	NN
cord-016300-vw11c2wt	80	32	to	to	IN
cord-016300-vw11c2wt	80	33	treatment	treatment	NN
cord-016300-vw11c2wt	80	34	.	.	.
cord-016300-vw11c2wt	81	1	Chronic	chronic	JJ
cord-016300-vw11c2wt	81	2	obstructive	obstructive	JJ
cord-016300-vw11c2wt	81	3	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	81	4	disease	disease	NN
cord-016300-vw11c2wt	81	5	(	(	-LRB-
cord-016300-vw11c2wt	81	6	COPD	COPD	NNP
cord-016300-vw11c2wt	81	7	)	)	-RRB-
cord-016300-vw11c2wt	81	8	consists	consist	VBZ
cord-016300-vw11c2wt	81	9	of	of	IN
cord-016300-vw11c2wt	81	10	two	two	CD
cord-016300-vw11c2wt	81	11	main	main	JJ
cord-016300-vw11c2wt	81	12	forms	form	NNS
cord-016300-vw11c2wt	81	13	−	−	NN
cord-016300-vw11c2wt	81	14	chronic	chronic	JJ
cord-016300-vw11c2wt	81	15	bronchitis	bronchitis	NN
cord-016300-vw11c2wt	81	16	and	and	CC
cord-016300-vw11c2wt	81	17	emphysema	emphysema	NN
cord-016300-vw11c2wt	81	18	−	−	NNS
cord-016300-vw11c2wt	81	19	and	and	CC
cord-016300-vw11c2wt	81	20	sufferers	sufferer	NNS
cord-016300-vw11c2wt	81	21	usually	usually	RB
cord-016300-vw11c2wt	81	22	have	have	VBP
cord-016300-vw11c2wt	81	23	a	a	DT
cord-016300-vw11c2wt	81	24	combination	combination	NN
cord-016300-vw11c2wt	81	25	of	of	IN
cord-016300-vw11c2wt	81	26	these	these	DT
cord-016300-vw11c2wt	81	27	conditions	condition	NNS
cord-016300-vw11c2wt	81	28	.	.	.
cord-016300-vw11c2wt	82	1	There	there	EX
cord-016300-vw11c2wt	82	2	has	have	VBZ
cord-016300-vw11c2wt	82	3	been	be	VBN
cord-016300-vw11c2wt	82	4	increasing	increase	VBG
cord-016300-vw11c2wt	82	5	interest	interest	NN
cord-016300-vw11c2wt	82	6	in	in	IN
cord-016300-vw11c2wt	82	7	using	use	VBG
cord-016300-vw11c2wt	82	8	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	82	9	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	82	10	to	to	TO
cord-016300-vw11c2wt	82	11	understand	understand	VB
cord-016300-vw11c2wt	82	12	and	and	CC
cord-016300-vw11c2wt	82	13	monitor	monitor	VB
cord-016300-vw11c2wt	82	14	the	the	DT
cord-016300-vw11c2wt	82	15	inflammation	inflammation	NN
cord-016300-vw11c2wt	82	16	in	in	IN
cord-016300-vw11c2wt	82	17	the	the	DT
cord-016300-vw11c2wt	82	18	respiratory	respiratory	JJ
cord-016300-vw11c2wt	82	19	tract	tract	NN
cord-016300-vw11c2wt	82	20	of	of	IN
cord-016300-vw11c2wt	82	21	patients	patient	NNS
cord-016300-vw11c2wt	82	22	with	with	IN
cord-016300-vw11c2wt	82	23	COPD	COPD	NNP
cord-016300-vw11c2wt	82	24	.	.	.
cord-016300-vw11c2wt	83	1	Bronchial	bronchial	JJ
cord-016300-vw11c2wt	83	2	biopsies	biopsy	NNS
cord-016300-vw11c2wt	83	3	and	and	CC
cord-016300-vw11c2wt	83	4	bronchoalveolar	bronchoalveolar	NNP
cord-016300-vw11c2wt	83	5	lavage	lavage	NN
cord-016300-vw11c2wt	83	6	provide	provide	VB
cord-016300-vw11c2wt	83	7	valuable	valuable	JJ
cord-016300-vw11c2wt	83	8	information	information	NN
cord-016300-vw11c2wt	83	9	about	about	IN
cord-016300-vw11c2wt	83	10	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	83	11	cells	cell	NNS
cord-016300-vw11c2wt	83	12	and	and	CC
cord-016300-vw11c2wt	83	13	mediators	mediator	NNS
cord-016300-vw11c2wt	83	14	,	,	,
cord-016300-vw11c2wt	83	15	but	but	CC
cord-016300-vw11c2wt	83	16	these	these	DT
cord-016300-vw11c2wt	83	17	procedures	procedure	NNS
cord-016300-vw11c2wt	83	18	are	be	VBP
cord-016300-vw11c2wt	83	19	invasive	invasive	JJ
cord-016300-vw11c2wt	83	20	,	,	,
cord-016300-vw11c2wt	83	21	so	so	IN
cord-016300-vw11c2wt	83	22	that	that	IN
cord-016300-vw11c2wt	83	23	repeated	repeat	VBN
cord-016300-vw11c2wt	83	24	measurements	measurement	NNS
cord-016300-vw11c2wt	83	25	are	be	VBP
cord-016300-vw11c2wt	83	26	limited	limited	JJ
cord-016300-vw11c2wt	83	27	.	.	.
cord-016300-vw11c2wt	84	1	Sputum	Sputum	NNP
cord-016300-vw11c2wt	84	2	provides	provide	VBZ
cord-016300-vw11c2wt	84	3	considerable	considerable	JJ
cord-016300-vw11c2wt	84	4	information	information	NN
cord-016300-vw11c2wt	84	5	about	about	IN
cord-016300-vw11c2wt	84	6	the	the	DT
cord-016300-vw11c2wt	84	7	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	84	8	process	process	NN
cord-016300-vw11c2wt	84	9	,	,	,
cord-016300-vw11c2wt	84	10	including	include	VBG
cord-016300-vw11c2wt	84	11	mediators	mediator	NNS
cord-016300-vw11c2wt	84	12	and	and	CC
cord-016300-vw11c2wt	84	13	proteinases	proteinase	NNS
cord-016300-vw11c2wt	84	14	in	in	IN
cord-016300-vw11c2wt	84	15	COPD	COPD	NNP
cord-016300-vw11c2wt	84	16	,	,	,
cord-016300-vw11c2wt	84	17	but	but	CC
cord-016300-vw11c2wt	84	18	samples	sample	NNS
cord-016300-vw11c2wt	84	19	usually	usually	RB
cord-016300-vw11c2wt	84	20	represent	represent	VBP
cord-016300-vw11c2wt	84	21	proximal	proximal	JJ
cord-016300-vw11c2wt	84	22	airways	airway	NNS
cord-016300-vw11c2wt	84	23	and	and	CC
cord-016300-vw11c2wt	84	24	may	may	MD
cord-016300-vw11c2wt	84	25	not	not	RB
cord-016300-vw11c2wt	84	26	reflect	reflect	VB
cord-016300-vw11c2wt	84	27	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	84	28	processes	process	NNS
cord-016300-vw11c2wt	84	29	in	in	IN
cord-016300-vw11c2wt	84	30	distal	distal	JJ
cord-016300-vw11c2wt	84	31	bronchi	bronchi	NN
cord-016300-vw11c2wt	84	32	.	.	.
cord-016300-vw11c2wt	85	1	Analysis	analysis	NN
cord-016300-vw11c2wt	85	2	of	of	IN
cord-016300-vw11c2wt	85	3	exhaled	exhaled	JJ
cord-016300-vw11c2wt	85	4	breath	breath	NN
cord-016300-vw11c2wt	85	5	is	be	VBZ
cord-016300-vw11c2wt	85	6	a	a	DT
cord-016300-vw11c2wt	85	7	noninvasive	noninvasive	JJ
cord-016300-vw11c2wt	85	8	procedure	procedure	NN
cord-016300-vw11c2wt	85	9	so	so	IN
cord-016300-vw11c2wt	85	10	that	that	IN
cord-016300-vw11c2wt	85	11	repeated	repeat	VBN
cord-016300-vw11c2wt	85	12	measurements	measurement	NNS
cord-016300-vw11c2wt	85	13	are	be	VBP
cord-016300-vw11c2wt	85	14	possible	possible	JJ
cord-016300-vw11c2wt	85	15	,	,	,
cord-016300-vw11c2wt	85	16	but	but	CC
cord-016300-vw11c2wt	85	17	the	the	DT
cord-016300-vw11c2wt	85	18	variability	variability	NN
cord-016300-vw11c2wt	85	19	is	be	VBZ
cord-016300-vw11c2wt	85	20	high	high	JJ
cord-016300-vw11c2wt	85	21	for	for	IN
cord-016300-vw11c2wt	85	22	some	some	DT
cord-016300-vw11c2wt	85	23	assays	assay	NNS
cord-016300-vw11c2wt	85	24	.	.	.
cord-016300-vw11c2wt	86	1	There	there	EX
cord-016300-vw11c2wt	86	2	is	be	VBZ
cord-016300-vw11c2wt	86	3	relatively	relatively	RB
cord-016300-vw11c2wt	86	4	little	little	JJ
cord-016300-vw11c2wt	86	5	information	information	NN
cord-016300-vw11c2wt	86	6	about	about	IN
cord-016300-vw11c2wt	86	7	how	how	WRB
cord-016300-vw11c2wt	86	8	any	any	DT
cord-016300-vw11c2wt	86	9	of	of	IN
cord-016300-vw11c2wt	86	10	these	these	DT
cord-016300-vw11c2wt	86	11	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	86	12	relate	relate	VBP
cord-016300-vw11c2wt	86	13	to	to	IN
cord-016300-vw11c2wt	86	14	other	other	JJ
cord-016300-vw11c2wt	86	15	clinical	clinical	JJ
cord-016300-vw11c2wt	86	16	outcomes	outcome	NNS
cord-016300-vw11c2wt	86	17	,	,	,
cord-016300-vw11c2wt	86	18	such	such	JJ
cord-016300-vw11c2wt	86	19	as	as	IN
cord-016300-vw11c2wt	86	20	progression	progression	NN
cord-016300-vw11c2wt	86	21	of	of	IN
cord-016300-vw11c2wt	86	22	the	the	DT
cord-016300-vw11c2wt	86	23	disease	disease	NN
cord-016300-vw11c2wt	86	24	,	,	,
cord-016300-vw11c2wt	86	25	severity	severity	NN
cord-016300-vw11c2wt	86	26	of	of	IN
cord-016300-vw11c2wt	86	27	disease	disease	NN
cord-016300-vw11c2wt	86	28	,	,	,
cord-016300-vw11c2wt	86	29	clinical	clinical	JJ
cord-016300-vw11c2wt	86	30	subtypes	subtype	NNS
cord-016300-vw11c2wt	86	31	or	or	CC
cord-016300-vw11c2wt	86	32	response	response	NN
cord-016300-vw11c2wt	86	33	to	to	IN
cord-016300-vw11c2wt	86	34	therapy	therapy	NN
cord-016300-vw11c2wt	86	35	.	.	.
cord-016300-vw11c2wt	87	1	More	More	JJR
cord-016300-vw11c2wt	87	2	information	information	NN
cord-016300-vw11c2wt	87	3	is	be	VBZ
cord-016300-vw11c2wt	87	4	also	also	RB
cord-016300-vw11c2wt	87	5	needed	need	VBN
cord-016300-vw11c2wt	87	6	about	about	IN
cord-016300-vw11c2wt	87	7	the	the	DT
cord-016300-vw11c2wt	87	8	variability	variability	NN
cord-016300-vw11c2wt	87	9	in	in	IN
cord-016300-vw11c2wt	87	10	these	these	DT
cord-016300-vw11c2wt	87	11	measurements	measurement	NNS
cord-016300-vw11c2wt	87	12	.	.	.
cord-016300-vw11c2wt	88	1	In	in	IN
cord-016300-vw11c2wt	88	2	the	the	DT
cord-016300-vw11c2wt	88	3	future	future	JJ
cord-016300-vw11c2wt	88	4	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	88	5	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	88	6	may	may	MD
cord-016300-vw11c2wt	88	7	be	be	VB
cord-016300-vw11c2wt	88	8	useful	useful	JJ
cord-016300-vw11c2wt	88	9	in	in	IN
cord-016300-vw11c2wt	88	10	predicting	predict	VBG
cord-016300-vw11c2wt	88	11	disease	disease	NN
cord-016300-vw11c2wt	88	12	progression	progression	NN
cord-016300-vw11c2wt	88	13	,	,	,
cord-016300-vw11c2wt	88	14	indicating	indicate	VBG
cord-016300-vw11c2wt	88	15	disease	disease	NN
cord-016300-vw11c2wt	88	16	instability	instability	NN
cord-016300-vw11c2wt	88	17	and	and	CC
cord-016300-vw11c2wt	88	18	in	in	IN
cord-016300-vw11c2wt	88	19	predicting	predict	VBG
cord-016300-vw11c2wt	88	20	response	response	NN
cord-016300-vw11c2wt	88	21	to	to	IN
cord-016300-vw11c2wt	88	22	current	current	JJ
cord-016300-vw11c2wt	88	23	therapies	therapy	NNS
cord-016300-vw11c2wt	88	24	and	and	CC
cord-016300-vw11c2wt	88	25	novel	novel	JJ
cord-016300-vw11c2wt	88	26	therapies	therapy	NNS
cord-016300-vw11c2wt	88	27	,	,	,
cord-016300-vw11c2wt	88	28	many	many	JJ
cord-016300-vw11c2wt	88	29	of	of	IN
cord-016300-vw11c2wt	88	30	which	which	WDT
cord-016300-vw11c2wt	88	31	are	be	VBP
cord-016300-vw11c2wt	88	32	now	now	RB
cord-016300-vw11c2wt	88	33	in	in	IN
cord-016300-vw11c2wt	88	34	development	development	NN
cord-016300-vw11c2wt	88	35	.	.	.
cord-016300-vw11c2wt	89	1	The	the	DT
cord-016300-vw11c2wt	89	2	COPD	COPD	NNP
cord-016300-vw11c2wt	89	3	Foundation	Foundation	NNP
cord-016300-vw11c2wt	89	4	Biomarker	Biomarker	NNP
cord-016300-vw11c2wt	89	5	Qualification	Qualification	NNP
cord-016300-vw11c2wt	89	6	Consortium	Consortium	NNP
cord-016300-vw11c2wt	89	7	(	(	-LRB-
cord-016300-vw11c2wt	89	8	CBQC	CBQC	NNP
cord-016300-vw11c2wt	89	9	)	)	-RRB-
cord-016300-vw11c2wt	89	10	is	be	VBZ
cord-016300-vw11c2wt	89	11	a	a	DT
cord-016300-vw11c2wt	89	12	unique	unique	JJ
cord-016300-vw11c2wt	89	13	public	public	JJ
cord-016300-vw11c2wt	89	14	-	-	HYPH
cord-016300-vw11c2wt	89	15	private	private	JJ
cord-016300-vw11c2wt	89	16	partnership	partnership	NN
cord-016300-vw11c2wt	89	17	established	establish	VBN
cord-016300-vw11c2wt	89	18	in	in	IN
cord-016300-vw11c2wt	89	19	2010	2010	CD
cord-016300-vw11c2wt	89	20	between	between	IN
cord-016300-vw11c2wt	89	21	the	the	DT
cord-016300-vw11c2wt	89	22	COPD	COPD	NNP
cord-016300-vw11c2wt	89	23	Foundation	Foundation	NNP
cord-016300-vw11c2wt	89	24	,	,	,
cord-016300-vw11c2wt	89	25	the	the	DT
cord-016300-vw11c2wt	89	26	pharmaceutical	pharmaceutical	NN
cord-016300-vw11c2wt	89	27	industry	industry	NN
cord-016300-vw11c2wt	89	28	,	,	,
cord-016300-vw11c2wt	89	29	and	and	CC
cord-016300-vw11c2wt	89	30	academic	academic	JJ
cord-016300-vw11c2wt	89	31	COPD	COPD	NNP
cord-016300-vw11c2wt	89	32	experts	expert	NNS
cord-016300-vw11c2wt	89	33	with	with	IN
cord-016300-vw11c2wt	89	34	advisors	advisor	NNS
cord-016300-vw11c2wt	89	35	from	from	IN
cord-016300-vw11c2wt	89	36	the	the	DT
cord-016300-vw11c2wt	89	37	US	US	NNP
cord-016300-vw11c2wt	89	38	National	National	NNP
cord-016300-vw11c2wt	89	39	Heart	Heart	NNP
cord-016300-vw11c2wt	89	40	Lung	Lung	NNP
cord-016300-vw11c2wt	89	41	&	&	CC
cord-016300-vw11c2wt	89	42	Blood	Blood	NNP
cord-016300-vw11c2wt	89	43	Institute	Institute	NNP
cord-016300-vw11c2wt	89	44	and	and	CC
cord-016300-vw11c2wt	89	45	FDA	FDA	NNP
cord-016300-vw11c2wt	90	1	(	(	-LRB-
cord-016300-vw11c2wt	90	2	Miller	Miller	NNP
cord-016300-vw11c2wt	90	3	et	et	NNP
cord-016300-vw11c2wt	90	4	al	al	NNP
cord-016300-vw11c2wt	90	5	.	.	.
cord-016300-vw11c2wt	90	6	2016	2016	CD
cord-016300-vw11c2wt	90	7	)	)	-RRB-
cord-016300-vw11c2wt	90	8	.	.	.
cord-016300-vw11c2wt	91	1	The	the	DT
cord-016300-vw11c2wt	91	2	initial	initial	JJ
cord-016300-vw11c2wt	91	3	intent	intent	NN
cord-016300-vw11c2wt	91	4	of	of	IN
cord-016300-vw11c2wt	91	5	the	the	DT
cord-016300-vw11c2wt	91	6	CBQC	CBQC	NNP
cord-016300-vw11c2wt	91	7	was	be	VBD
cord-016300-vw11c2wt	91	8	to	to	TO
cord-016300-vw11c2wt	91	9	integrate	integrate	VB
cord-016300-vw11c2wt	91	10	data	datum	NNS
cord-016300-vw11c2wt	91	11	collected	collect	VBN
cord-016300-vw11c2wt	91	12	in	in	IN
cord-016300-vw11c2wt	91	13	2009	2009	CD
cord-016300-vw11c2wt	91	14	and	and	CC
cord-016300-vw11c2wt	91	15	submit	submit	VB
cord-016300-vw11c2wt	91	16	a	a	DT
cord-016300-vw11c2wt	91	17	dossier	dossier	NN
cord-016300-vw11c2wt	91	18	for	for	IN
cord-016300-vw11c2wt	91	19	the	the	DT
cord-016300-vw11c2wt	91	20	qualification	qualification	NN
cord-016300-vw11c2wt	91	21	.	.	.
cord-016300-vw11c2wt	92	1	This	this	DT
cord-016300-vw11c2wt	92	2	led	lead	VBD
cord-016300-vw11c2wt	92	3	to	to	IN
cord-016300-vw11c2wt	92	4	the	the	DT
cord-016300-vw11c2wt	92	5	FDA	FDA	NNP
cord-016300-vw11c2wt	92	6	qualification	qualification	NN
cord-016300-vw11c2wt	92	7	of	of	IN
cord-016300-vw11c2wt	92	8	plasma	plasma	NN
cord-016300-vw11c2wt	92	9	fibrinogen	fibrinogen	NN
cord-016300-vw11c2wt	92	10	as	as	IN
cord-016300-vw11c2wt	92	11	a	a	DT
cord-016300-vw11c2wt	92	12	prognostic	prognostic	JJ
cord-016300-vw11c2wt	92	13	or	or	CC
cord-016300-vw11c2wt	92	14	enrichment	enrichment	NN
cord-016300-vw11c2wt	92	15	biomarker	biomarker	NN
cord-016300-vw11c2wt	92	16	for	for	IN
cord-016300-vw11c2wt	92	17	all	all	DT
cord-016300-vw11c2wt	92	18	-	-	HYPH
cord-016300-vw11c2wt	92	19	cause	cause	NN
cord-016300-vw11c2wt	92	20	mortality	mortality	NN
cord-016300-vw11c2wt	92	21	and	and	CC
cord-016300-vw11c2wt	92	22	COPD	COPD	NNP
cord-016300-vw11c2wt	92	23	exacerbations	exacerbation	NNS
cord-016300-vw11c2wt	92	24	in	in	IN
cord-016300-vw11c2wt	92	25	2015	2015	CD
cord-016300-vw11c2wt	92	26	.	.	.
cord-016300-vw11c2wt	93	1	It	-PRON-	PRP
cord-016300-vw11c2wt	93	2	is	be	VBZ
cord-016300-vw11c2wt	93	3	the	the	DT
cord-016300-vw11c2wt	93	4	first	first	JJ
cord-016300-vw11c2wt	93	5	biomarker	biomarker	NN
cord-016300-vw11c2wt	93	6	drug	drug	NN
cord-016300-vw11c2wt	93	7	development	development	NN
cord-016300-vw11c2wt	93	8	tool	tool	NN
cord-016300-vw11c2wt	93	9	qualified	qualify	VBN
cord-016300-vw11c2wt	93	10	for	for	IN
cord-016300-vw11c2wt	93	11	use	use	NN
cord-016300-vw11c2wt	93	12	in	in	IN
cord-016300-vw11c2wt	93	13	COPD	COPD	NNP
cord-016300-vw11c2wt	93	14	under	under	IN
cord-016300-vw11c2wt	93	15	the	the	DT
cord-016300-vw11c2wt	93	16	FDA	FDA	NNP
cord-016300-vw11c2wt	93	17	's	's	POS
cord-016300-vw11c2wt	93	18	drug	drug	NN
cord-016300-vw11c2wt	93	19	development	development	NN
cord-016300-vw11c2wt	93	20	tool	tool	NN
cord-016300-vw11c2wt	93	21	qualification	qualification	NN
cord-016300-vw11c2wt	93	22	program	program	NN
cord-016300-vw11c2wt	93	23	.	.	.
cord-016300-vw11c2wt	94	1	Alpha1-antitrypsin	Alpha1-antitrypsin	NNP
cord-016300-vw11c2wt	94	2	(	(	-LRB-
cord-016300-vw11c2wt	94	3	AAT	AAT	NNP
cord-016300-vw11c2wt	94	4	)	)	-RRB-
cord-016300-vw11c2wt	94	5	is	be	VBZ
cord-016300-vw11c2wt	94	6	a	a	DT
cord-016300-vw11c2wt	94	7	plasma	plasma	NN
cord-016300-vw11c2wt	94	8	glycoprotein	glycoprotein	NN
cord-016300-vw11c2wt	94	9	that	that	WDT
cord-016300-vw11c2wt	94	10	inhibits	inhibit	VBZ
cord-016300-vw11c2wt	94	11	neutrophil	neutrophil	NN
cord-016300-vw11c2wt	94	12	elastase	elastase	NN
cord-016300-vw11c2wt	94	13	,	,	,
cord-016300-vw11c2wt	94	14	and	and	CC
cord-016300-vw11c2wt	94	15	individuals	individual	NNS
cord-016300-vw11c2wt	94	16	who	who	WP
cord-016300-vw11c2wt	94	17	inherit	inherit	VBP
cord-016300-vw11c2wt	94	18	altered	alter	VBN
cord-016300-vw11c2wt	94	19	AAT	AAT	NNP
cord-016300-vw11c2wt	94	20	genes	gene	NNS
cord-016300-vw11c2wt	94	21	resulting	result	VBG
cord-016300-vw11c2wt	94	22	in	in	IN
cord-016300-vw11c2wt	94	23	deficiency	deficiency	NN
cord-016300-vw11c2wt	94	24	of	of	IN
cord-016300-vw11c2wt	94	25	the	the	DT
cord-016300-vw11c2wt	94	26	protein	protein	NN
cord-016300-vw11c2wt	94	27	are	be	VBP
cord-016300-vw11c2wt	94	28	at	at	IN
cord-016300-vw11c2wt	94	29	high	high	JJ
cord-016300-vw11c2wt	94	30	risk	risk	NN
cord-016300-vw11c2wt	94	31	for	for	IN
cord-016300-vw11c2wt	94	32	COPD	COPD	NNP
cord-016300-vw11c2wt	94	33	and	and	CC
cord-016300-vw11c2wt	94	34	liver	liver	NN
cord-016300-vw11c2wt	94	35	cirrhosis	cirrhosis	NN
cord-016300-vw11c2wt	94	36	.	.	.
cord-016300-vw11c2wt	95	1	This	this	DT
cord-016300-vw11c2wt	95	2	deficiency	deficiency	NN
cord-016300-vw11c2wt	95	3	can	can	MD
cord-016300-vw11c2wt	95	4	be	be	VB
cord-016300-vw11c2wt	95	5	detected	detect	VBN
cord-016300-vw11c2wt	95	6	by	by	IN
cord-016300-vw11c2wt	95	7	serum	serum	NN
cord-016300-vw11c2wt	95	8	protein	protein	NN
cord-016300-vw11c2wt	95	9	pattern	pattern	NN
cord-016300-vw11c2wt	95	10	studies	study	NNS
cord-016300-vw11c2wt	95	11	.	.	.
cord-016300-vw11c2wt	96	1	In	in	IN
cord-016300-vw11c2wt	96	2	the	the	DT
cord-016300-vw11c2wt	96	3	past	past	NN
cord-016300-vw11c2wt	96	4	,	,	,
cord-016300-vw11c2wt	96	5	testing	test	VBG
cord-016300-vw11c2wt	96	6	for	for	IN
cord-016300-vw11c2wt	96	7	the	the	DT
cord-016300-vw11c2wt	96	8	deficiency	deficiency	NN
cord-016300-vw11c2wt	96	9	has	have	VBZ
cord-016300-vw11c2wt	96	10	been	be	VBN
cord-016300-vw11c2wt	96	11	done	do	VBN
cord-016300-vw11c2wt	96	12	retrospectively	retrospectively	RB
cord-016300-vw11c2wt	96	13	in	in	IN
cord-016300-vw11c2wt	96	14	patients	patient	NNS
cord-016300-vw11c2wt	96	15	with	with	IN
cord-016300-vw11c2wt	96	16	COPD	COPD	NNP
cord-016300-vw11c2wt	96	17	or	or	CC
cord-016300-vw11c2wt	96	18	liver	liver	NN
cord-016300-vw11c2wt	96	19	disease	disease	NN
cord-016300-vw11c2wt	96	20	,	,	,
cord-016300-vw11c2wt	96	21	but	but	CC
cord-016300-vw11c2wt	96	22	the	the	DT
cord-016300-vw11c2wt	96	23	introduction	introduction	NN
cord-016300-vw11c2wt	96	24	of	of	IN
cord-016300-vw11c2wt	96	25	a	a	DT
cord-016300-vw11c2wt	96	26	home	home	NN
cord-016300-vw11c2wt	96	27	-	-	HYPH
cord-016300-vw11c2wt	96	28	administered	administer	VBN
cord-016300-vw11c2wt	96	29	finger	finger	NN
cord-016300-vw11c2wt	96	30	-	-	HYPH
cord-016300-vw11c2wt	96	31	stick	stick	VB
cord-016300-vw11c2wt	96	32	blood	blood	NN
cord-016300-vw11c2wt	96	33	spot	spot	NN
cord-016300-vw11c2wt	96	34	test	test	NN
cord-016300-vw11c2wt	96	35	for	for	IN
cord-016300-vw11c2wt	96	36	AAT	AAT	NNP
cord-016300-vw11c2wt	96	37	genotype	genotype	NN
cord-016300-vw11c2wt	96	38	enables	enable	NNS
cord-016300-vw11c2wt	96	39	affected	affect	VBN
cord-016300-vw11c2wt	96	40	families	family	NNS
cord-016300-vw11c2wt	96	41	to	to	TO
cord-016300-vw11c2wt	96	42	construct	construct	VB
cord-016300-vw11c2wt	96	43	pedigrees	pedigree	NNS
cord-016300-vw11c2wt	96	44	to	to	TO
cord-016300-vw11c2wt	96	45	enable	enable	VB
cord-016300-vw11c2wt	96	46	them	-PRON-	PRP
cord-016300-vw11c2wt	96	47	to	to	TO
cord-016300-vw11c2wt	96	48	identify	identify	VB
cord-016300-vw11c2wt	96	49	children	child	NNS
cord-016300-vw11c2wt	96	50	who	who	WP
cord-016300-vw11c2wt	96	51	are	be	VBP
cord-016300-vw11c2wt	96	52	at	at	IN
cord-016300-vw11c2wt	96	53	risk	risk	NN
cord-016300-vw11c2wt	96	54	for	for	IN
cord-016300-vw11c2wt	96	55	developing	develop	VBG
cord-016300-vw11c2wt	96	56	COPD	COPD	NNP
cord-016300-vw11c2wt	96	57	in	in	IN
cord-016300-vw11c2wt	96	58	later	later	JJ
cord-016300-vw11c2wt	96	59	life	life	NN
cord-016300-vw11c2wt	96	60	and	and	CC
cord-016300-vw11c2wt	96	61	should	should	MD
cord-016300-vw11c2wt	96	62	avoid	avoid	VB
cord-016300-vw11c2wt	96	63	exposure	exposure	NN
cord-016300-vw11c2wt	96	64	to	to	IN
cord-016300-vw11c2wt	96	65	dust	dust	NN
cord-016300-vw11c2wt	96	66	and	and	CC
cord-016300-vw11c2wt	96	67	smoke	smoke	NN
cord-016300-vw11c2wt	96	68	.	.	.
cord-016300-vw11c2wt	97	1	Extracellular	Extracellular	NNP
cord-016300-vw11c2wt	97	2	matrix	matrix	NN
cord-016300-vw11c2wt	97	3	(	(	-LRB-
cord-016300-vw11c2wt	97	4	ECM	ECM	NNP
cord-016300-vw11c2wt	97	5	)	)	-RRB-
cord-016300-vw11c2wt	97	6	remodeling	remodeling	NN
cord-016300-vw11c2wt	97	7	of	of	IN
cord-016300-vw11c2wt	97	8	the	the	DT
cord-016300-vw11c2wt	97	9	lung	lung	NN
cord-016300-vw11c2wt	97	10	tissue	tissue	NN
cord-016300-vw11c2wt	97	11	releases	release	VBZ
cord-016300-vw11c2wt	97	12	protein	protein	NN
cord-016300-vw11c2wt	97	13	fragments	fragment	NNS
cord-016300-vw11c2wt	97	14	into	into	IN
cord-016300-vw11c2wt	97	15	the	the	DT
cord-016300-vw11c2wt	97	16	blood	blood	NN
cord-016300-vw11c2wt	97	17	,	,	,
cord-016300-vw11c2wt	97	18	where	where	WRB
cord-016300-vw11c2wt	97	19	they	-PRON-	PRP
cord-016300-vw11c2wt	97	20	may	may	MD
cord-016300-vw11c2wt	97	21	be	be	VB
cord-016300-vw11c2wt	97	22	detected	detect	VBN
cord-016300-vw11c2wt	97	23	as	as	IN
cord-016300-vw11c2wt	97	24	serologic	serologic	JJ
cord-016300-vw11c2wt	97	25	surrogate	surrogate	JJ
cord-016300-vw11c2wt	97	26	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	97	27	of	of	IN
cord-016300-vw11c2wt	97	28	disease	disease	NN
cord-016300-vw11c2wt	97	29	activity	activity	NN
cord-016300-vw11c2wt	97	30	in	in	IN
cord-016300-vw11c2wt	97	31	COPD	COPD	NNP
cord-016300-vw11c2wt	97	32	.	.	.
cord-016300-vw11c2wt	98	1	Association	Association	NNP
cord-016300-vw11c2wt	98	2	of	of	IN
cord-016300-vw11c2wt	98	3	ECM	ECM	NNP
cord-016300-vw11c2wt	98	4	turnover	turnover	NN
cord-016300-vw11c2wt	98	5	with	with	IN
cord-016300-vw11c2wt	98	6	severity	severity	NN
cord-016300-vw11c2wt	98	7	and	and	CC
cord-016300-vw11c2wt	98	8	outcome	outcome	NN
cord-016300-vw11c2wt	98	9	of	of	IN
cord-016300-vw11c2wt	98	10	COPD	COPD	NNP
cord-016300-vw11c2wt	98	11	has	have	VBZ
cord-016300-vw11c2wt	98	12	been	be	VBN
cord-016300-vw11c2wt	98	13	assessed	assess	VBN
cord-016300-vw11c2wt	98	14	in	in	IN
cord-016300-vw11c2wt	98	15	a	a	DT
cord-016300-vw11c2wt	98	16	prospective	prospective	JJ
cord-016300-vw11c2wt	98	17	,	,	,
cord-016300-vw11c2wt	98	18	observational	observational	JJ
cord-016300-vw11c2wt	98	19	,	,	,
cord-016300-vw11c2wt	98	20	multicenter	multicenter	JJ
cord-016300-vw11c2wt	98	21	study	study	NN
cord-016300-vw11c2wt	98	22	,	,	,
cord-016300-vw11c2wt	98	23	Global	Global	NNP
cord-016300-vw11c2wt	98	24	Initiative	Initiative	NNP
cord-016300-vw11c2wt	98	25	for	for	IN
cord-016300-vw11c2wt	98	26	Chronic	Chronic	NNP
cord-016300-vw11c2wt	98	27	Obstructive	Obstructive	NNP
cord-016300-vw11c2wt	98	28	Lung	Lung	NNP
cord-016300-vw11c2wt	98	29	Disease	Disease	NNP
cord-016300-vw11c2wt	98	30	grades	grade	VBZ
cord-016300-vw11c2wt	98	31	II	II	NNP
cord-016300-vw11c2wt	98	32	to	to	IN
cord-016300-vw11c2wt	98	33	IV	IV	NNP
cord-016300-vw11c2wt	98	34	,	,	,
cord-016300-vw11c2wt	98	35	and	and	CC
cord-016300-vw11c2wt	98	36	serum	serum	NN
cord-016300-vw11c2wt	98	37	samples	sample	NNS
cord-016300-vw11c2wt	98	38	were	be	VBD
cord-016300-vw11c2wt	98	39	analyzed	analyze	VBN
cord-016300-vw11c2wt	98	40	at	at	IN
cord-016300-vw11c2wt	98	41	stable	stable	JJ
cord-016300-vw11c2wt	98	42	state	state	NN
cord-016300-vw11c2wt	98	43	,	,	,
cord-016300-vw11c2wt	98	44	during	during	IN
cord-016300-vw11c2wt	98	45	exacerbation	exacerbation	NN
cord-016300-vw11c2wt	98	46	as	as	RB
cord-016300-vw11c2wt	98	47	well	well	RB
cord-016300-vw11c2wt	98	48	as	as	IN
cord-016300-vw11c2wt	98	49	4	4	CD
cord-016300-vw11c2wt	98	50	weeks	week	NNS
cord-016300-vw11c2wt	98	51	after	after	IN
cord-016300-vw11c2wt	98	52	exacerbation	exacerbation	NN
cord-016300-vw11c2wt	99	1	(	(	-LRB-
cord-016300-vw11c2wt	99	2	Stolz	Stolz	NNP
cord-016300-vw11c2wt	99	3	et	et	NNP
cord-016300-vw11c2wt	99	4	al	al	NNP
cord-016300-vw11c2wt	99	5	.	.	.
cord-016300-vw11c2wt	99	6	2017	2017	CD
cord-016300-vw11c2wt	99	7	)	)	-RRB-
cord-016300-vw11c2wt	99	8	.	.	.
cord-016300-vw11c2wt	100	1	Results	result	NNS
cord-016300-vw11c2wt	100	2	showed	show	VBD
cord-016300-vw11c2wt	100	3	that	that	IN
cord-016300-vw11c2wt	100	4	patients	patient	NNS
cord-016300-vw11c2wt	100	5	with	with	IN
cord-016300-vw11c2wt	100	6	the	the	DT
cord-016300-vw11c2wt	100	7	lowest	low	JJS
cord-016300-vw11c2wt	100	8	levels	level	NNS
cord-016300-vw11c2wt	100	9	of	of	IN
cord-016300-vw11c2wt	100	10	pro	pro	JJ
cord-016300-vw11c2wt	100	11	-	-	JJ
cord-016300-vw11c2wt	100	12	forms	form	NNS
cord-016300-vw11c2wt	100	13	of	of	IN
cord-016300-vw11c2wt	100	14	collagen	collagen	NN
cord-016300-vw11c2wt	100	15	type	type	NN
cord-016300-vw11c2wt	100	16	III	III	NNP
cord-016300-vw11c2wt	100	17	(	(	-LRB-
cord-016300-vw11c2wt	100	18	Pro	pro	JJ
cord-016300-vw11c2wt	100	19	-	-	JJ
cord-016300-vw11c2wt	100	20	C3	c3	JJ
cord-016300-vw11c2wt	100	21	)	)	-RRB-
cord-016300-vw11c2wt	100	22	and	and	CC
cord-016300-vw11c2wt	100	23	type	type	NN
cord-016300-vw11c2wt	100	24	VI	VI	NNP
cord-016300-vw11c2wt	100	25	(	(	-LRB-
cord-016300-vw11c2wt	100	26	Pro	Pro	NNP
cord-016300-vw11c2wt	100	27	-	-	JJ
cord-016300-vw11c2wt	100	28	C6	C6	NNP
cord-016300-vw11c2wt	100	29	)	)	-RRB-
cord-016300-vw11c2wt	100	30	had	have	VBD
cord-016300-vw11c2wt	100	31	more	more	RBR
cord-016300-vw11c2wt	100	32	severe	severe	JJ
cord-016300-vw11c2wt	100	33	airflow	airflow	NN
cord-016300-vw11c2wt	100	34	limitation	limitation	NN
cord-016300-vw11c2wt	100	35	,	,	,
cord-016300-vw11c2wt	100	36	hyperinflation	hyperinflation	NN
cord-016300-vw11c2wt	100	37	,	,	,
cord-016300-vw11c2wt	100	38	air	air	NN
cord-016300-vw11c2wt	100	39	trapping	trapping	NN
cord-016300-vw11c2wt	100	40	,	,	,
cord-016300-vw11c2wt	100	41	and	and	CC
cord-016300-vw11c2wt	100	42	emphysema	emphysema	NN
cord-016300-vw11c2wt	100	43	.	.	.
cord-016300-vw11c2wt	101	1	Collagen	collagen	NN
cord-016300-vw11c2wt	101	2	type	type	NN
cord-016300-vw11c2wt	101	3	III	III	NNP
cord-016300-vw11c2wt	101	4	(	(	-LRB-
cord-016300-vw11c2wt	101	5	C3	C3	NNP
cord-016300-vw11c2wt	101	6	M	M	NNP
cord-016300-vw11c2wt	101	7	)	)	-RRB-
cord-016300-vw11c2wt	101	8	and	and	CC
cord-016300-vw11c2wt	101	9	collagen	collagen	NN
cord-016300-vw11c2wt	101	10	type	type	NN
cord-016300-vw11c2wt	101	11	VI	VI	NNP
cord-016300-vw11c2wt	101	12	(	(	-LRB-
cord-016300-vw11c2wt	101	13	C6	C6	NNP
cord-016300-vw11c2wt	101	14	M	M	NNP
cord-016300-vw11c2wt	101	15	)	)	-RRB-
cord-016300-vw11c2wt	101	16	were	be	VBD
cord-016300-vw11c2wt	101	17	associated	associate	VBN
cord-016300-vw11c2wt	101	18	with	with	IN
cord-016300-vw11c2wt	101	19	dyspnea	dyspnea	NN
cord-016300-vw11c2wt	101	20	.	.	.
cord-016300-vw11c2wt	102	1	In	in	IN
cord-016300-vw11c2wt	102	2	conclusion	conclusion	NN
cord-016300-vw11c2wt	102	3	,	,	,
cord-016300-vw11c2wt	102	4	serum	serum	NN
cord-016300-vw11c2wt	102	5	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	102	6	of	of	IN
cord-016300-vw11c2wt	102	7	ECM	ECM	NNP
cord-016300-vw11c2wt	102	8	turnover	turnover	NN
cord-016300-vw11c2wt	102	9	were	be	VBD
cord-016300-vw11c2wt	102	10	significantly	significantly	RB
cord-016300-vw11c2wt	102	11	associated	associate	VBN
cord-016300-vw11c2wt	102	12	with	with	IN
cord-016300-vw11c2wt	102	13	disease	disease	NN
cord-016300-vw11c2wt	102	14	severity	severity	NN
cord-016300-vw11c2wt	102	15	and	and	CC
cord-016300-vw11c2wt	102	16	clinically	clinically	RB
cord-016300-vw11c2wt	102	17	relevant	relevant	JJ
cord-016300-vw11c2wt	102	18	outcomes	outcome	NNS
cord-016300-vw11c2wt	102	19	in	in	IN
cord-016300-vw11c2wt	102	20	patients	patient	NNS
cord-016300-vw11c2wt	102	21	with	with	IN
cord-016300-vw11c2wt	102	22	COPD	COPD	NNP
cord-016300-vw11c2wt	102	23	.	.	.
cord-016300-vw11c2wt	103	1	Lung	Lung	NNP
cord-016300-vw11c2wt	103	2	ECM	ECM	NNP
cord-016300-vw11c2wt	103	3	remodeling	remodeling	NN
cord-016300-vw11c2wt	103	4	in	in	IN
cord-016300-vw11c2wt	103	5	healthy	healthy	JJ
cord-016300-vw11c2wt	103	6	controls	control	NNS
cord-016300-vw11c2wt	103	7	and	and	CC
cord-016300-vw11c2wt	103	8	COPD	COPD	NNP
cord-016300-vw11c2wt	103	9	patients	patient	NNS
cord-016300-vw11c2wt	103	10	was	be	VBD
cord-016300-vw11c2wt	103	11	investigated	investigate	VBN
cord-016300-vw11c2wt	103	12	in	in	IN
cord-016300-vw11c2wt	103	13	the	the	DT
cord-016300-vw11c2wt	103	14	COPDGene	copdgene	JJ
cord-016300-vw11c2wt	103	15	study	study	NN
cord-016300-vw11c2wt	103	16	.	.	.
cord-016300-vw11c2wt	104	1	The	the	DT
cord-016300-vw11c2wt	104	2	data	datum	NNS
cord-016300-vw11c2wt	104	3	suggest	suggest	VBP
cord-016300-vw11c2wt	104	4	that	that	IN
cord-016300-vw11c2wt	104	5	type	type	NN
cord-016300-vw11c2wt	104	6	VI	VI	NNP
cord-016300-vw11c2wt	104	7	collagen	collagen	NN
cord-016300-vw11c2wt	104	8	turnover	turnover	NN
cord-016300-vw11c2wt	104	9	and	and	CC
cord-016300-vw11c2wt	104	10	elastin	elastin	NN
cord-016300-vw11c2wt	104	11	degradation	degradation	NN
cord-016300-vw11c2wt	104	12	by	by	IN
cord-016300-vw11c2wt	104	13	neutrophil	neutrophil	NN
cord-016300-vw11c2wt	104	14	elastase	elastase	NN
cord-016300-vw11c2wt	104	15	are	be	VBP
cord-016300-vw11c2wt	104	16	associated	associate	VBN
cord-016300-vw11c2wt	104	17	with	with	IN
cord-016300-vw11c2wt	104	18	COPD	COPD	NNP
cord-016300-vw11c2wt	104	19	-	-	HYPH
cord-016300-vw11c2wt	104	20	induced	induce	VBN
cord-016300-vw11c2wt	104	21	inflammation	inflammation	NN
cord-016300-vw11c2wt	104	22	(	(	-LRB-
cord-016300-vw11c2wt	104	23	eosinophil	eosinophil	NN
cord-016300-vw11c2wt	104	24	-	-	HYPH
cord-016300-vw11c2wt	104	25	bronchitis	bronchitis	NN
cord-016300-vw11c2wt	104	26	)	)	-RRB-
cord-016300-vw11c2wt	104	27	and	and	CC
cord-016300-vw11c2wt	104	28	emphysema	emphysema	NN
cord-016300-vw11c2wt	104	29	(	(	-LRB-
cord-016300-vw11c2wt	104	30	Bihlet	Bihlet	NNP
cord-016300-vw11c2wt	104	31	et	et	NNP
cord-016300-vw11c2wt	104	32	al	al	NNP
cord-016300-vw11c2wt	104	33	.	.	.
cord-016300-vw11c2wt	104	34	2017	2017	CD
cord-016300-vw11c2wt	104	35	)	)	-RRB-
cord-016300-vw11c2wt	104	36	.	.	.
cord-016300-vw11c2wt	105	1	Serological	serological	JJ
cord-016300-vw11c2wt	105	2	assessment	assessment	NN
cord-016300-vw11c2wt	105	3	of	of	IN
cord-016300-vw11c2wt	105	4	type	type	NN
cord-016300-vw11c2wt	105	5	VI	vi	NN
cord-016300-vw11c2wt	105	6	collagen	collagen	NN
cord-016300-vw11c2wt	105	7	and	and	CC
cord-016300-vw11c2wt	105	8	elastin	elastin	NN
cord-016300-vw11c2wt	105	9	turnover	turnover	NN
cord-016300-vw11c2wt	105	10	may	may	MD
cord-016300-vw11c2wt	105	11	assist	assist	VB
cord-016300-vw11c2wt	105	12	in	in	IN
cord-016300-vw11c2wt	105	13	identification	identification	NN
cord-016300-vw11c2wt	105	14	of	of	IN
cord-016300-vw11c2wt	105	15	phenotypes	phenotype	NNS
cord-016300-vw11c2wt	105	16	likely	likely	JJ
cord-016300-vw11c2wt	105	17	to	to	TO
cord-016300-vw11c2wt	105	18	be	be	VB
cord-016300-vw11c2wt	105	19	associated	associate	VBN
cord-016300-vw11c2wt	105	20	with	with	IN
cord-016300-vw11c2wt	105	21	progression	progression	NN
cord-016300-vw11c2wt	105	22	and	and	CC
cord-016300-vw11c2wt	105	23	amenable	amenable	JJ
cord-016300-vw11c2wt	105	24	to	to	IN
cord-016300-vw11c2wt	105	25	precision	precision	NN
cord-016300-vw11c2wt	105	26	medicine	medicine	NN
cord-016300-vw11c2wt	105	27	for	for	IN
cord-016300-vw11c2wt	105	28	clinical	clinical	JJ
cord-016300-vw11c2wt	105	29	trials	trial	NNS
cord-016300-vw11c2wt	105	30	.	.	.
cord-016300-vw11c2wt	106	1	Lung	lung	NN
cord-016300-vw11c2wt	106	2	failure	failure	NN
cord-016300-vw11c2wt	106	3	,	,	,
cord-016300-vw11c2wt	106	4	also	also	RB
cord-016300-vw11c2wt	106	5	termed	term	VBD
cord-016300-vw11c2wt	106	6	"	"	``
cord-016300-vw11c2wt	106	7	lung	lung	NN
cord-016300-vw11c2wt	106	8	attack	attack	NN
cord-016300-vw11c2wt	106	9	"	"	''
cord-016300-vw11c2wt	106	10	,	,	,
cord-016300-vw11c2wt	106	11	is	be	VBZ
cord-016300-vw11c2wt	106	12	the	the	DT
cord-016300-vw11c2wt	106	13	most	most	RBS
cord-016300-vw11c2wt	106	14	common	common	JJ
cord-016300-vw11c2wt	106	15	organ	organ	NN
cord-016300-vw11c2wt	106	16	failure	failure	NN
cord-016300-vw11c2wt	106	17	seen	see	VBN
cord-016300-vw11c2wt	106	18	in	in	IN
cord-016300-vw11c2wt	106	19	the	the	DT
cord-016300-vw11c2wt	106	20	intensive	intensive	JJ
cord-016300-vw11c2wt	106	21	care	care	NN
cord-016300-vw11c2wt	106	22	unit	unit	NN
cord-016300-vw11c2wt	106	23	.	.	.
cord-016300-vw11c2wt	107	1	Lung	lung	NN
cord-016300-vw11c2wt	107	2	attacks	attack	NNS
cord-016300-vw11c2wt	107	3	,	,	,
cord-016300-vw11c2wt	107	4	which	which	WDT
cord-016300-vw11c2wt	107	5	effect	effect	VBP
cord-016300-vw11c2wt	107	6	individuals	individual	NNS
cord-016300-vw11c2wt	107	7	with	with	IN
cord-016300-vw11c2wt	107	8	COPD	COPD	NNP
cord-016300-vw11c2wt	107	9	are	be	VBP
cord-016300-vw11c2wt	107	10	among	among	IN
cord-016300-vw11c2wt	107	11	the	the	DT
cord-016300-vw11c2wt	107	12	leading	leading	JJ
cord-016300-vw11c2wt	107	13	cause	cause	NN
cord-016300-vw11c2wt	107	14	of	of	IN
cord-016300-vw11c2wt	107	15	visits	visit	NNS
cord-016300-vw11c2wt	107	16	to	to	IN
cord-016300-vw11c2wt	107	17	emergency	emergency	NN
cord-016300-vw11c2wt	107	18	rooms	room	NNS
cord-016300-vw11c2wt	107	19	among	among	IN
cord-016300-vw11c2wt	107	20	chronic	chronic	JJ
cord-016300-vw11c2wt	107	21	disease	disease	NN
cord-016300-vw11c2wt	107	22	sufferers	sufferer	NNS
cord-016300-vw11c2wt	107	23	.	.	.
cord-016300-vw11c2wt	108	1	Other	other	JJ
cord-016300-vw11c2wt	108	2	causes	cause	NNS
cord-016300-vw11c2wt	108	3	are	be	VBP
cord-016300-vw11c2wt	108	4	neuromuscular	neuromuscular	JJ
cord-016300-vw11c2wt	108	5	impairment	impairment	NN
cord-016300-vw11c2wt	108	6	,	,	,
cord-016300-vw11c2wt	108	7	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	108	8	edema	edema	NN
cord-016300-vw11c2wt	108	9	,	,	,
cord-016300-vw11c2wt	108	10	pneumonia	pneumonia	NN
cord-016300-vw11c2wt	108	11	,	,	,
cord-016300-vw11c2wt	108	12	and	and	CC
cord-016300-vw11c2wt	108	13	vascular	vascular	JJ
cord-016300-vw11c2wt	108	14	diseases	disease	NNS
cord-016300-vw11c2wt	108	15	such	such	JJ
cord-016300-vw11c2wt	108	16	as	as	IN
cord-016300-vw11c2wt	108	17	acute	acute	JJ
cord-016300-vw11c2wt	108	18	or	or	CC
cord-016300-vw11c2wt	108	19	chronic	chronic	JJ
cord-016300-vw11c2wt	108	20	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	108	21	embolism	embolism	NN
cord-016300-vw11c2wt	108	22	.	.	.
cord-016300-vw11c2wt	109	1	When	when	WRB
cord-016300-vw11c2wt	109	2	a	a	DT
cord-016300-vw11c2wt	109	3	patient	patient	NN
cord-016300-vw11c2wt	109	4	is	be	VBZ
cord-016300-vw11c2wt	109	5	admitted	admit	VBN
cord-016300-vw11c2wt	109	6	into	into	IN
cord-016300-vw11c2wt	109	7	the	the	DT
cord-016300-vw11c2wt	109	8	hospital	hospital	NN
cord-016300-vw11c2wt	109	9	with	with	IN
cord-016300-vw11c2wt	109	10	a	a	DT
cord-016300-vw11c2wt	109	11	severe	severe	JJ
cord-016300-vw11c2wt	109	12	lung	lung	NN
cord-016300-vw11c2wt	109	13	failure	failure	NN
cord-016300-vw11c2wt	109	14	,	,	,
cord-016300-vw11c2wt	109	15	it	-PRON-	PRP
cord-016300-vw11c2wt	109	16	usually	usually	RB
cord-016300-vw11c2wt	109	17	takes	take	VBZ
cord-016300-vw11c2wt	109	18	>	>	XX
cord-016300-vw11c2wt	109	19	3	3	CD
cord-016300-vw11c2wt	109	20	months	month	NNS
cord-016300-vw11c2wt	109	21	to	to	TO
cord-016300-vw11c2wt	109	22	get	get	VB
cord-016300-vw11c2wt	109	23	to	to	IN
cord-016300-vw11c2wt	109	24	80	80	CD
cord-016300-vw11c2wt	109	25	%	%	NN
cord-016300-vw11c2wt	109	26	of	of	IN
cord-016300-vw11c2wt	109	27	his	-PRON-	PRP$
cord-016300-vw11c2wt	109	28	or	or	CC
cord-016300-vw11c2wt	109	29	her	-PRON-	PRP$
cord-016300-vw11c2wt	109	30	baseline	baseline	JJ
cord-016300-vw11c2wt	109	31	health	health	NN
cord-016300-vw11c2wt	109	32	.	.	.
cord-016300-vw11c2wt	110	1	If	if	IN
cord-016300-vw11c2wt	110	2	the	the	DT
cord-016300-vw11c2wt	110	3	patient	patient	NN
cord-016300-vw11c2wt	110	4	's	's	POS
cord-016300-vw11c2wt	110	5	health	health	NN
cord-016300-vw11c2wt	110	6	is	be	VBZ
cord-016300-vw11c2wt	110	7	poor	poor	JJ
cord-016300-vw11c2wt	110	8	to	to	TO
cord-016300-vw11c2wt	110	9	start	start	VB
cord-016300-vw11c2wt	110	10	with	with	IN
cord-016300-vw11c2wt	110	11	,	,	,
cord-016300-vw11c2wt	110	12	the	the	DT
cord-016300-vw11c2wt	110	13	new	new	JJ
cord-016300-vw11c2wt	110	14	attack	attack	NN
cord-016300-vw11c2wt	110	15	can	can	MD
cord-016300-vw11c2wt	110	16	be	be	VB
cord-016300-vw11c2wt	110	17	devastating	devastating	JJ
cord-016300-vw11c2wt	110	18	or	or	CC
cord-016300-vw11c2wt	110	19	even	even	RB
cord-016300-vw11c2wt	110	20	fatal	fatal	JJ
cord-016300-vw11c2wt	110	21	.	.	.
cord-016300-vw11c2wt	111	1	A	a	DT
cord-016300-vw11c2wt	111	2	test	test	NN
cord-016300-vw11c2wt	111	3	that	that	WDT
cord-016300-vw11c2wt	111	4	could	could	MD
cord-016300-vw11c2wt	111	5	more	more	RBR
cord-016300-vw11c2wt	111	6	accurately	accurately	RB
cord-016300-vw11c2wt	111	7	present	present	VB
cord-016300-vw11c2wt	111	8	a	a	DT
cord-016300-vw11c2wt	111	9	patient	patient	NN
cord-016300-vw11c2wt	111	10	's	's	POS
cord-016300-vw11c2wt	111	11	disease	disease	NN
cord-016300-vw11c2wt	111	12	could	could	MD
cord-016300-vw11c2wt	111	13	make	make	VB
cord-016300-vw11c2wt	111	14	it	-PRON-	PRP
cord-016300-vw11c2wt	111	15	easier	easy	JJR
cord-016300-vw11c2wt	111	16	to	to	TO
cord-016300-vw11c2wt	111	17	predict	predict	VB
cord-016300-vw11c2wt	111	18	and	and	CC
cord-016300-vw11c2wt	111	19	treat	treat	VB
cord-016300-vw11c2wt	111	20	COPD	COPD	NNP
cord-016300-vw11c2wt	111	21	progression	progression	NN
cord-016300-vw11c2wt	111	22	to	to	IN
cord-016300-vw11c2wt	111	23	lung	lung	NN
cord-016300-vw11c2wt	111	24	failure	failure	NN
cord-016300-vw11c2wt	111	25	.	.	.
cord-016300-vw11c2wt	112	1	There	there	EX
cord-016300-vw11c2wt	112	2	is	be	VBZ
cord-016300-vw11c2wt	112	3	need	need	NN
cord-016300-vw11c2wt	112	4	for	for	IN
cord-016300-vw11c2wt	112	5	a	a	DT
cord-016300-vw11c2wt	112	6	test	test	NN
cord-016300-vw11c2wt	112	7	that	that	WDT
cord-016300-vw11c2wt	112	8	could	could	MD
cord-016300-vw11c2wt	112	9	be	be	VB
cord-016300-vw11c2wt	112	10	performed	perform	VBN
cord-016300-vw11c2wt	112	11	in	in	IN
cord-016300-vw11c2wt	112	12	any	any	DT
cord-016300-vw11c2wt	112	13	clinical	clinical	JJ
cord-016300-vw11c2wt	112	14	lab	lab	NN
cord-016300-vw11c2wt	112	15	and	and	CC
cord-016300-vw11c2wt	112	16	could	could	MD
cord-016300-vw11c2wt	112	17	be	be	VB
cord-016300-vw11c2wt	112	18	used	use	VBN
cord-016300-vw11c2wt	112	19	far	far	RB
cord-016300-vw11c2wt	112	20	more	more	RBR
cord-016300-vw11c2wt	112	21	widely	widely	RB
cord-016300-vw11c2wt	112	22	than	than	IN
cord-016300-vw11c2wt	112	23	the	the	DT
cord-016300-vw11c2wt	112	24	current	current	JJ
cord-016300-vw11c2wt	112	25	lung	lung	NN
cord-016300-vw11c2wt	112	26	function	function	NN
cord-016300-vw11c2wt	112	27	tests	test	NNS
cord-016300-vw11c2wt	112	28	,	,	,
cord-016300-vw11c2wt	112	29	which	which	WDT
cord-016300-vw11c2wt	112	30	are	be	VBP
cord-016300-vw11c2wt	112	31	performed	perform	VBN
cord-016300-vw11c2wt	112	32	in	in	IN
cord-016300-vw11c2wt	112	33	certain	certain	JJ
cord-016300-vw11c2wt	112	34	centers	center	NNS
cord-016300-vw11c2wt	112	35	by	by	IN
cord-016300-vw11c2wt	112	36	specially	specially	RB
cord-016300-vw11c2wt	112	37	trained	train	VBN
cord-016300-vw11c2wt	112	38	personnel	personnel	NNS
cord-016300-vw11c2wt	112	39	.	.	.
cord-016300-vw11c2wt	113	1	In	in	IN
cord-016300-vw11c2wt	113	2	2012	2012	CD
cord-016300-vw11c2wt	113	3	,	,	,
cord-016300-vw11c2wt	113	4	Canada	Canada	NNP
cord-016300-vw11c2wt	113	5	's	's	POS
cord-016300-vw11c2wt	113	6	Prevention	Prevention	NNP
cord-016300-vw11c2wt	113	7	of	of	IN
cord-016300-vw11c2wt	113	8	Organ	Organ	NNP
cord-016300-vw11c2wt	113	9	Failure	Failure	NNP
cord-016300-vw11c2wt	113	10	(	(	-LRB-
cord-016300-vw11c2wt	113	11	PROOF	PROOF	NNP
cord-016300-vw11c2wt	113	12	)	)	-RRB-
cord-016300-vw11c2wt	113	13	Center	Center	NNP
cord-016300-vw11c2wt	113	14	of	of	IN
cord-016300-vw11c2wt	113	15	Excellence	Excellence	NNP
cord-016300-vw11c2wt	113	16	in	in	IN
cord-016300-vw11c2wt	113	17	Vancouver	Vancouver	NNP
cord-016300-vw11c2wt	113	18	received	receive	VBD
cord-016300-vw11c2wt	113	19	funding	funding	NN
cord-016300-vw11c2wt	113	20	from	from	IN
cord-016300-vw11c2wt	113	21	Genome	Genome	NNP
cord-016300-vw11c2wt	113	22	British	British	NNP
cord-016300-vw11c2wt	113	23	Columbia	Columbia	NNP
cord-016300-vw11c2wt	113	24	to	to	TO
cord-016300-vw11c2wt	113	25	develop	develop	VB
cord-016300-vw11c2wt	113	26	a	a	DT
cord-016300-vw11c2wt	113	27	biomarkerbased	biomarkerbased	JJ
cord-016300-vw11c2wt	113	28	test	test	NN
cord-016300-vw11c2wt	113	29	for	for	IN
cord-016300-vw11c2wt	113	30	determining	determine	VBG
cord-016300-vw11c2wt	113	31	a	a	DT
cord-016300-vw11c2wt	113	32	COPD	COPD	NNP
cord-016300-vw11c2wt	113	33	patient	patient	NN
cord-016300-vw11c2wt	113	34	's	's	POS
cord-016300-vw11c2wt	113	35	risk	risk	NN
cord-016300-vw11c2wt	113	36	for	for	IN
cord-016300-vw11c2wt	113	37	having	have	VBG
cord-016300-vw11c2wt	113	38	a	a	DT
cord-016300-vw11c2wt	113	39	lung	lung	NN
cord-016300-vw11c2wt	113	40	attack	attack	NN
cord-016300-vw11c2wt	113	41	.	.	.
cord-016300-vw11c2wt	114	1	Genes	gene	NNS
cord-016300-vw11c2wt	114	2	and	and	CC
cord-016300-vw11c2wt	114	3	protein	protein	NN
cord-016300-vw11c2wt	114	4	biomarker	biomarker	NN
cord-016300-vw11c2wt	114	5	sets	set	NNS
cord-016300-vw11c2wt	114	6	that	that	WDT
cord-016300-vw11c2wt	114	7	have	have	VBP
cord-016300-vw11c2wt	114	8	been	be	VBN
cord-016300-vw11c2wt	114	9	discovered	discover	VBN
cord-016300-vw11c2wt	114	10	at	at	IN
cord-016300-vw11c2wt	114	11	PROOF	PROOF	NNP
cord-016300-vw11c2wt	114	12	Center	Center	NNP
cord-016300-vw11c2wt	114	13	could	could	MD
cord-016300-vw11c2wt	114	14	have	have	VB
cord-016300-vw11c2wt	114	15	the	the	DT
cord-016300-vw11c2wt	114	16	ability	ability	NN
cord-016300-vw11c2wt	114	17	to	to	TO
cord-016300-vw11c2wt	114	18	predict	predict	VB
cord-016300-vw11c2wt	114	19	COPD	COPD	NNP
cord-016300-vw11c2wt	114	20	-	-	HYPH
cord-016300-vw11c2wt	114	21	caused	cause	VBN
cord-016300-vw11c2wt	114	22	lung	lung	NN
cord-016300-vw11c2wt	114	23	attacks	attack	NNS
cord-016300-vw11c2wt	114	24	and	and	CC
cord-016300-vw11c2wt	114	25	need	need	VBP
cord-016300-vw11c2wt	114	26	to	to	TO
cord-016300-vw11c2wt	114	27	be	be	VB
cord-016300-vw11c2wt	114	28	validated	validate	VBN
cord-016300-vw11c2wt	114	29	.	.	.
cord-016300-vw11c2wt	115	1	Circulating	circulate	VBG
cord-016300-vw11c2wt	115	2	BNP	BNP	NNP
cord-016300-vw11c2wt	115	3	levels	level	NNS
cord-016300-vw11c2wt	115	4	were	be	VBD
cord-016300-vw11c2wt	115	5	evaluated	evaluate	VBN
cord-016300-vw11c2wt	115	6	as	as	IN
cord-016300-vw11c2wt	115	7	a	a	DT
cord-016300-vw11c2wt	115	8	parameter	parameter	NN
cord-016300-vw11c2wt	115	9	for	for	IN
cord-016300-vw11c2wt	115	10	the	the	DT
cord-016300-vw11c2wt	115	11	presence	presence	NN
cord-016300-vw11c2wt	115	12	and	and	CC
cord-016300-vw11c2wt	115	13	severity	severity	NN
cord-016300-vw11c2wt	115	14	of	of	IN
cord-016300-vw11c2wt	115	15	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	115	16	hypertension	hypertension	NN
cord-016300-vw11c2wt	115	17	(	(	-LRB-
cord-016300-vw11c2wt	115	18	PH	PH	NNP
cord-016300-vw11c2wt	115	19	)	)	-RRB-
cord-016300-vw11c2wt	115	20	in	in	IN
cord-016300-vw11c2wt	115	21	patients	patient	NNS
cord-016300-vw11c2wt	115	22	with	with	IN
cord-016300-vw11c2wt	115	23	chronic	chronic	JJ
cord-016300-vw11c2wt	115	24	lung	lung	NN
cord-016300-vw11c2wt	115	25	disease	disease	NN
cord-016300-vw11c2wt	115	26	(	(	-LRB-
cord-016300-vw11c2wt	115	27	Leuchte	Leuchte	NNP
cord-016300-vw11c2wt	115	28	et	et	NNP
cord-016300-vw11c2wt	115	29	al	al	NNP
cord-016300-vw11c2wt	115	30	.	.	.
cord-016300-vw11c2wt	115	31	2006	2006	CD
cord-016300-vw11c2wt	115	32	)	)	-RRB-
cord-016300-vw11c2wt	115	33	.	.	.
cord-016300-vw11c2wt	116	1	During	during	IN
cord-016300-vw11c2wt	116	2	a	a	DT
cord-016300-vw11c2wt	116	3	follow	follow	NN
cord-016300-vw11c2wt	116	4	-	-	HYPH
cord-016300-vw11c2wt	116	5	up	up	NN
cord-016300-vw11c2wt	116	6	time	time	NN
cord-016300-vw11c2wt	116	7	of	of	IN
cord-016300-vw11c2wt	116	8	approximately	approximately	RB
cord-016300-vw11c2wt	116	9	1	1	CD
cord-016300-vw11c2wt	116	10	year	year	NN
cord-016300-vw11c2wt	116	11	,	,	,
cord-016300-vw11c2wt	116	12	significant	significant	JJ
cord-016300-vw11c2wt	116	13	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	116	14	hypertension	hypertension	NN
cord-016300-vw11c2wt	116	15	(	(	-LRB-
cord-016300-vw11c2wt	116	16	mean	mean	VB
cord-016300-vw11c2wt	116	17	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	116	18	artery	artery	NN
cord-016300-vw11c2wt	116	19	pressure	pressure	NN
cord-016300-vw11c2wt	116	20	>	>	XX
cord-016300-vw11c2wt	117	1	35	35	CD
cord-016300-vw11c2wt	117	2	mm	mm	CD
cord-016300-vw11c2wt	117	3	Hg	Hg	NNP
cord-016300-vw11c2wt	117	4	)	)	-RRB-
cord-016300-vw11c2wt	117	5	was	be	VBD
cord-016300-vw11c2wt	117	6	diagnosed	diagnose	VBN
cord-016300-vw11c2wt	117	7	in	in	IN
cord-016300-vw11c2wt	117	8	more	more	JJR
cord-016300-vw11c2wt	117	9	than	than	IN
cord-016300-vw11c2wt	117	10	one	one	CD
cord-016300-vw11c2wt	117	11	-	-	HYPH
cord-016300-vw11c2wt	117	12	fourth	fourth	NN
cord-016300-vw11c2wt	117	13	of	of	IN
cord-016300-vw11c2wt	117	14	patients	patient	NNS
cord-016300-vw11c2wt	117	15	and	and	CC
cord-016300-vw11c2wt	117	16	led	lead	VBD
cord-016300-vw11c2wt	117	17	to	to	IN
cord-016300-vw11c2wt	117	18	decreased	decrease	VBN
cord-016300-vw11c2wt	117	19	exercise	exercise	NN
cord-016300-vw11c2wt	117	20	tolerance	tolerance	NN
cord-016300-vw11c2wt	117	21	and	and	CC
cord-016300-vw11c2wt	117	22	life	life	NN
cord-016300-vw11c2wt	117	23	expectancy	expectancy	NN
cord-016300-vw11c2wt	117	24	.	.	.
cord-016300-vw11c2wt	118	1	Elevated	elevated	JJ
cord-016300-vw11c2wt	118	2	BNP	BNP	NNP
cord-016300-vw11c2wt	118	3	concentrations	concentration	NNS
cord-016300-vw11c2wt	118	4	identified	identify	VBD
cord-016300-vw11c2wt	118	5	significant	significant	JJ
cord-016300-vw11c2wt	118	6	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	118	7	hypertension	hypertension	NN
cord-016300-vw11c2wt	118	8	with	with	IN
cord-016300-vw11c2wt	118	9	a	a	DT
cord-016300-vw11c2wt	118	10	sensitivity	sensitivity	NN
cord-016300-vw11c2wt	118	11	of	of	IN
cord-016300-vw11c2wt	118	12	0.85	0.85	CD
cord-016300-vw11c2wt	118	13	and	and	CC
cord-016300-vw11c2wt	118	14	specificity	specificity	NN
cord-016300-vw11c2wt	118	15	of	of	IN
cord-016300-vw11c2wt	118	16	0.88	0.88	CD
cord-016300-vw11c2wt	118	17	and	and	CC
cord-016300-vw11c2wt	118	18	predicted	predict	VBD
cord-016300-vw11c2wt	118	19	mortality	mortality	NN
cord-016300-vw11c2wt	118	20	.	.	.
cord-016300-vw11c2wt	119	1	Moreover	moreover	RB
cord-016300-vw11c2wt	119	2	,	,	,
cord-016300-vw11c2wt	119	3	BNP	BNP	NNP
cord-016300-vw11c2wt	119	4	served	serve	VBD
cord-016300-vw11c2wt	119	5	as	as	IN
cord-016300-vw11c2wt	119	6	a	a	DT
cord-016300-vw11c2wt	119	7	risk	risk	NN
cord-016300-vw11c2wt	119	8	factor	factor	NN
cord-016300-vw11c2wt	119	9	of	of	IN
cord-016300-vw11c2wt	119	10	death	death	NN
cord-016300-vw11c2wt	119	11	independent	independent	JJ
cord-016300-vw11c2wt	119	12	of	of	IN
cord-016300-vw11c2wt	119	13	lung	lung	NN
cord-016300-vw11c2wt	119	14	functional	functional	JJ
cord-016300-vw11c2wt	119	15	impairment	impairment	NN
cord-016300-vw11c2wt	119	16	or	or	CC
cord-016300-vw11c2wt	119	17	hypoxemia	hypoxemia	NN
cord-016300-vw11c2wt	119	18	.	.	.
cord-016300-vw11c2wt	120	1	It	-PRON-	PRP
cord-016300-vw11c2wt	120	2	is	be	VBZ
cord-016300-vw11c2wt	120	3	concluded	conclude	VBN
cord-016300-vw11c2wt	120	4	that	that	IN
cord-016300-vw11c2wt	120	5	plasma	plasma	NN
cord-016300-vw11c2wt	120	6	BNP	BNP	NNP
cord-016300-vw11c2wt	120	7	facilitates	facilitate	VBZ
cord-016300-vw11c2wt	120	8	noninvasive	noninvasive	JJ
cord-016300-vw11c2wt	120	9	detection	detection	NN
cord-016300-vw11c2wt	120	10	of	of	IN
cord-016300-vw11c2wt	120	11	significant	significant	JJ
cord-016300-vw11c2wt	120	12	PH	ph	NN
cord-016300-vw11c2wt	120	13	with	with	IN
cord-016300-vw11c2wt	120	14	high	high	JJ
cord-016300-vw11c2wt	120	15	accuracy	accuracy	NN
cord-016300-vw11c2wt	120	16	and	and	CC
cord-016300-vw11c2wt	120	17	can	can	MD
cord-016300-vw11c2wt	120	18	be	be	VB
cord-016300-vw11c2wt	120	19	used	use	VBN
cord-016300-vw11c2wt	120	20	as	as	IN
cord-016300-vw11c2wt	120	21	a	a	DT
cord-016300-vw11c2wt	120	22	screening	screening	NN
cord-016300-vw11c2wt	120	23	test	test	NN
cord-016300-vw11c2wt	120	24	for	for	IN
cord-016300-vw11c2wt	120	25	the	the	DT
cord-016300-vw11c2wt	120	26	presence	presence	NN
cord-016300-vw11c2wt	120	27	of	of	IN
cord-016300-vw11c2wt	120	28	PH	PH	NNP
cord-016300-vw11c2wt	120	29	.	.	.
cord-016300-vw11c2wt	121	1	In	in	IN
cord-016300-vw11c2wt	121	2	addition	addition	NN
cord-016300-vw11c2wt	121	3	,	,	,
cord-016300-vw11c2wt	121	4	BNP	BNP	NNP
cord-016300-vw11c2wt	121	5	enables	enable	VBZ
cord-016300-vw11c2wt	121	6	an	an	DT
cord-016300-vw11c2wt	121	7	assessment	assessment	NN
cord-016300-vw11c2wt	121	8	of	of	IN
cord-016300-vw11c2wt	121	9	the	the	DT
cord-016300-vw11c2wt	121	10	relevance	relevance	NN
cord-016300-vw11c2wt	121	11	of	of	IN
cord-016300-vw11c2wt	121	12	PH	PH	NNP
cord-016300-vw11c2wt	121	13	and	and	CC
cord-016300-vw11c2wt	121	14	could	could	MD
cord-016300-vw11c2wt	121	15	serve	serve	VB
cord-016300-vw11c2wt	121	16	as	as	IN
cord-016300-vw11c2wt	121	17	a	a	DT
cord-016300-vw11c2wt	121	18	useful	useful	JJ
cord-016300-vw11c2wt	121	19	prognostic	prognostic	JJ
cord-016300-vw11c2wt	121	20	parameter	parameter	NN
cord-016300-vw11c2wt	121	21	in	in	IN
cord-016300-vw11c2wt	121	22	chronic	chronic	JJ
cord-016300-vw11c2wt	121	23	lung	lung	NN
cord-016300-vw11c2wt	121	24	disease	disease	NN
cord-016300-vw11c2wt	121	25	.	.	.
cord-016300-vw11c2wt	122	1	A	a	DT
cord-016300-vw11c2wt	122	2	study	study	NN
cord-016300-vw11c2wt	122	3	has	have	VBZ
cord-016300-vw11c2wt	122	4	revealed	reveal	VBN
cord-016300-vw11c2wt	122	5	that	that	IN
cord-016300-vw11c2wt	122	6	serum	serum	NN
cord-016300-vw11c2wt	122	7	levels	level	NNS
cord-016300-vw11c2wt	122	8	of	of	IN
cord-016300-vw11c2wt	122	9	the	the	DT
cord-016300-vw11c2wt	122	10	neuroendocrine	neuroendocrine	JJ
cord-016300-vw11c2wt	122	11	activity	activity	NN
cord-016300-vw11c2wt	122	12	biomarker	biomarker	NN
cord-016300-vw11c2wt	122	13	chromagranin	chromagranin	NNS
cord-016300-vw11c2wt	122	14	A	A	NNP
cord-016300-vw11c2wt	122	15	(	(	-LRB-
cord-016300-vw11c2wt	122	16	CgA	CgA	NNP
cord-016300-vw11c2wt	122	17	)	)	-RRB-
cord-016300-vw11c2wt	122	18	are	be	VBP
cord-016300-vw11c2wt	122	19	increased	increase	VBN
cord-016300-vw11c2wt	122	20	in	in	IN
cord-016300-vw11c2wt	122	21	male	male	JJ
cord-016300-vw11c2wt	122	22	smokers	smoker	NNS
cord-016300-vw11c2wt	122	23	with	with	IN
cord-016300-vw11c2wt	122	24	impaired	impaired	JJ
cord-016300-vw11c2wt	122	25	lung	lung	NN
cord-016300-vw11c2wt	122	26	function	function	NN
cord-016300-vw11c2wt	122	27	,	,	,
cord-016300-vw11c2wt	122	28	and	and	CC
cord-016300-vw11c2wt	122	29	are	be	VBP
cord-016300-vw11c2wt	122	30	associated	associate	VBN
cord-016300-vw11c2wt	122	31	with	with	IN
cord-016300-vw11c2wt	122	32	both	both	DT
cord-016300-vw11c2wt	122	33	respiratory	respiratory	JJ
cord-016300-vw11c2wt	122	34	symptoms	symptom	NNS
cord-016300-vw11c2wt	122	35	and	and	CC
cord-016300-vw11c2wt	122	36	the	the	DT
cord-016300-vw11c2wt	122	37	degree	degree	NN
cord-016300-vw11c2wt	122	38	of	of	IN
cord-016300-vw11c2wt	122	39	airway	airway	JJ
cord-016300-vw11c2wt	122	40	obstruction	obstruction	NN
cord-016300-vw11c2wt	122	41	(	(	-LRB-
cord-016300-vw11c2wt	122	42	Sorhaug	Sorhaug	NNP
cord-016300-vw11c2wt	122	43	et	et	NNP
cord-016300-vw11c2wt	122	44	al	al	NNP
cord-016300-vw11c2wt	122	45	.	.	.
cord-016300-vw11c2wt	122	46	2006	2006	CD
cord-016300-vw11c2wt	122	47	)	)	-RRB-
cord-016300-vw11c2wt	122	48	.	.	.
cord-016300-vw11c2wt	123	1	The	the	DT
cord-016300-vw11c2wt	123	2	subgroup	subgroup	NN
cord-016300-vw11c2wt	123	3	of	of	IN
cord-016300-vw11c2wt	123	4	airway	airway	JJ
cord-016300-vw11c2wt	123	5	epithelial	epithelial	JJ
cord-016300-vw11c2wt	123	6	cells	cell	NNS
cord-016300-vw11c2wt	123	7	belonging	belong	VBG
cord-016300-vw11c2wt	123	8	to	to	IN
cord-016300-vw11c2wt	123	9	the	the	DT
cord-016300-vw11c2wt	123	10	diffuse	diffuse	JJ
cord-016300-vw11c2wt	123	11	neuroendocrine	neuroendocrine	JJ
cord-016300-vw11c2wt	123	12	system	system	NN
cord-016300-vw11c2wt	123	13	,	,	,
cord-016300-vw11c2wt	123	14	termed	term	VBD
cord-016300-vw11c2wt	123	15	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	123	16	neuroendocrine	neuroendocrine	JJ
cord-016300-vw11c2wt	123	17	cells	cell	NNS
cord-016300-vw11c2wt	123	18	,	,	,
cord-016300-vw11c2wt	123	19	may	may	MD
cord-016300-vw11c2wt	123	20	represent	represent	VB
cord-016300-vw11c2wt	123	21	a	a	DT
cord-016300-vw11c2wt	123	22	putative	putative	JJ
cord-016300-vw11c2wt	123	23	regulatory	regulatory	JJ
cord-016300-vw11c2wt	123	24	function	function	NN
cord-016300-vw11c2wt	123	25	of	of	IN
cord-016300-vw11c2wt	123	26	CgA	CgA	NNP
cord-016300-vw11c2wt	123	27	as	as	IN
cord-016300-vw11c2wt	123	28	a	a	DT
cord-016300-vw11c2wt	123	29	prohormone	prohormone	NN
cord-016300-vw11c2wt	123	30	.	.	.
cord-016300-vw11c2wt	124	1	They	-PRON-	PRP
cord-016300-vw11c2wt	124	2	are	be	VBP
cord-016300-vw11c2wt	124	3	considered	consider	VBN
cord-016300-vw11c2wt	124	4	to	to	TO
cord-016300-vw11c2wt	124	5	control	control	VB
cord-016300-vw11c2wt	124	6	growth	growth	NN
cord-016300-vw11c2wt	124	7	and	and	CC
cord-016300-vw11c2wt	124	8	development	development	NN
cord-016300-vw11c2wt	124	9	of	of	IN
cord-016300-vw11c2wt	124	10	the	the	DT
cord-016300-vw11c2wt	124	11	fetal	fetal	JJ
cord-016300-vw11c2wt	124	12	lung	lung	NN
cord-016300-vw11c2wt	124	13	and	and	CC
cord-016300-vw11c2wt	124	14	regulation	regulation	NN
cord-016300-vw11c2wt	124	15	of	of	IN
cord-016300-vw11c2wt	124	16	ventilation	ventilation	NN
cord-016300-vw11c2wt	124	17	and	and	CC
cord-016300-vw11c2wt	124	18	circulation	circulation	NN
cord-016300-vw11c2wt	124	19	,	,	,
cord-016300-vw11c2wt	124	20	but	but	CC
cord-016300-vw11c2wt	124	21	may	may	MD
cord-016300-vw11c2wt	124	22	also	also	RB
cord-016300-vw11c2wt	124	23	have	have	VB
cord-016300-vw11c2wt	124	24	a	a	DT
cord-016300-vw11c2wt	124	25	role	role	NN
cord-016300-vw11c2wt	124	26	in	in	IN
cord-016300-vw11c2wt	124	27	the	the	DT
cord-016300-vw11c2wt	124	28	pathogenesis	pathogenesis	NN
cord-016300-vw11c2wt	124	29	of	of	IN
cord-016300-vw11c2wt	124	30	smoking	smoking	NN
cord-016300-vw11c2wt	124	31	-	-	HYPH
cord-016300-vw11c2wt	124	32	induced	induce	VBN
cord-016300-vw11c2wt	124	33	airway	airway	NN
cord-016300-vw11c2wt	124	34	disease	disease	NN
cord-016300-vw11c2wt	124	35	.	.	.
cord-016300-vw11c2wt	125	1	The	the	DT
cord-016300-vw11c2wt	125	2	findings	finding	NNS
cord-016300-vw11c2wt	125	3	indicate	indicate	VBP
cord-016300-vw11c2wt	125	4	that	that	IN
cord-016300-vw11c2wt	125	5	neuroendocrine	neuroendocrine	JJ
cord-016300-vw11c2wt	125	6	activation	activation	NN
cord-016300-vw11c2wt	125	7	may	may	MD
cord-016300-vw11c2wt	125	8	be	be	VB
cord-016300-vw11c2wt	125	9	important	important	JJ
cord-016300-vw11c2wt	125	10	in	in	IN
cord-016300-vw11c2wt	125	11	smoking	smoking	NN
cord-016300-vw11c2wt	125	12	-	-	HYPH
cord-016300-vw11c2wt	125	13	related	relate	VBN
cord-016300-vw11c2wt	125	14	airway	airway	NN
cord-016300-vw11c2wt	125	15	inflammation	inflammation	NN
cord-016300-vw11c2wt	125	16	and	and	CC
cord-016300-vw11c2wt	125	17	remodeling	remodeling	NN
cord-016300-vw11c2wt	125	18	,	,	,
cord-016300-vw11c2wt	125	19	and	and	CC
cord-016300-vw11c2wt	125	20	raise	raise	VB
cord-016300-vw11c2wt	125	21	the	the	DT
cord-016300-vw11c2wt	125	22	possibility	possibility	NN
cord-016300-vw11c2wt	125	23	that	that	IN
cord-016300-vw11c2wt	125	24	CgA	CgA	NNP
cord-016300-vw11c2wt	125	25	could	could	MD
cord-016300-vw11c2wt	125	26	be	be	VB
cord-016300-vw11c2wt	125	27	of	of	IN
cord-016300-vw11c2wt	125	28	predictive	predictive	JJ
cord-016300-vw11c2wt	125	29	value	value	NN
cord-016300-vw11c2wt	125	30	as	as	IN
cord-016300-vw11c2wt	125	31	a	a	DT
cord-016300-vw11c2wt	125	32	biomarker	biomarker	NN
cord-016300-vw11c2wt	125	33	of	of	IN
cord-016300-vw11c2wt	125	34	prognosis	prognosis	NN
cord-016300-vw11c2wt	125	35	in	in	IN
cord-016300-vw11c2wt	125	36	smoking	smoking	NN
cord-016300-vw11c2wt	125	37	-	-	HYPH
cord-016300-vw11c2wt	125	38	associated	associate	VBN
cord-016300-vw11c2wt	125	39	diseases	disease	NNS
cord-016300-vw11c2wt	125	40	.	.	.
cord-016300-vw11c2wt	126	1	Measurements	measurement	NNS
cord-016300-vw11c2wt	126	2	of	of	IN
cord-016300-vw11c2wt	126	3	C	C	NNP
cord-016300-vw11c2wt	126	4	-	-	HYPH
cord-016300-vw11c2wt	126	5	reactive	reactive	JJ
cord-016300-vw11c2wt	126	6	protein	protein	NN
cord-016300-vw11c2wt	126	7	(	(	-LRB-
cord-016300-vw11c2wt	126	8	CRP	CRP	NNP
cord-016300-vw11c2wt	126	9	)	)	-RRB-
cord-016300-vw11c2wt	126	10	,	,	,
cord-016300-vw11c2wt	126	11	a	a	DT
cord-016300-vw11c2wt	126	12	biomarker	biomarker	NN
cord-016300-vw11c2wt	126	13	of	of	IN
cord-016300-vw11c2wt	126	14	inflammation	inflammation	NN
cord-016300-vw11c2wt	126	15	,	,	,
cord-016300-vw11c2wt	126	16	provide	provide	VB
cord-016300-vw11c2wt	126	17	incremental	incremental	JJ
cord-016300-vw11c2wt	126	18	prognostic	prognostic	JJ
cord-016300-vw11c2wt	126	19	information	information	NN
cord-016300-vw11c2wt	126	20	beyond	beyond	IN
cord-016300-vw11c2wt	126	21	that	that	DT
cord-016300-vw11c2wt	126	22	achieved	achieve	VBN
cord-016300-vw11c2wt	126	23	by	by	IN
cord-016300-vw11c2wt	126	24	traditional	traditional	JJ
cord-016300-vw11c2wt	126	25	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	126	26	in	in	IN
cord-016300-vw11c2wt	126	27	patients	patient	NNS
cord-016300-vw11c2wt	126	28	with	with	IN
cord-016300-vw11c2wt	126	29	mild	mild	JJ
cord-016300-vw11c2wt	126	30	to	to	IN
cord-016300-vw11c2wt	126	31	moderate	moderate	JJ
cord-016300-vw11c2wt	126	32	COPD	COPD	NNP
cord-016300-vw11c2wt	126	33	,	,	,
cord-016300-vw11c2wt	126	34	and	and	CC
cord-016300-vw11c2wt	126	35	may	may	MD
cord-016300-vw11c2wt	126	36	enable	enable	VB
cord-016300-vw11c2wt	126	37	more	more	RBR
cord-016300-vw11c2wt	126	38	accurate	accurate	JJ
cord-016300-vw11c2wt	126	39	detection	detection	NN
cord-016300-vw11c2wt	126	40	of	of	IN
cord-016300-vw11c2wt	126	41	patients	patient	NNS
cord-016300-vw11c2wt	126	42	at	at	IN
cord-016300-vw11c2wt	126	43	a	a	DT
cord-016300-vw11c2wt	126	44	high	high	JJ
cord-016300-vw11c2wt	126	45	risk	risk	NN
cord-016300-vw11c2wt	126	46	of	of	IN
cord-016300-vw11c2wt	126	47	mortality	mortality	NN
cord-016300-vw11c2wt	126	48	.	.	.
cord-016300-vw11c2wt	127	1	Lung	lung	NN
cord-016300-vw11c2wt	127	2	function	function	NN
cord-016300-vw11c2wt	127	3	decline	decline	NN
cord-016300-vw11c2wt	127	4	is	be	VBZ
cord-016300-vw11c2wt	127	5	significantly	significantly	RB
cord-016300-vw11c2wt	127	6	related	relate	VBN
cord-016300-vw11c2wt	127	7	to	to	IN
cord-016300-vw11c2wt	127	8	CRP	crp	NN
cord-016300-vw11c2wt	127	9	levels	level	NNS
cord-016300-vw11c2wt	127	10	,	,	,
cord-016300-vw11c2wt	127	11	with	with	IN
cord-016300-vw11c2wt	127	12	an	an	DT
cord-016300-vw11c2wt	127	13	average	average	JJ
cord-016300-vw11c2wt	127	14	predicted	predict	VBN
cord-016300-vw11c2wt	127	15	change	change	NN
cord-016300-vw11c2wt	127	16	in	in	IN
cord-016300-vw11c2wt	127	17	FEV1	FEV1	NNP
cord-016300-vw11c2wt	127	18	of	of	IN
cord-016300-vw11c2wt	127	19	−0.93	−0.93	NNP
cord-016300-vw11c2wt	127	20	%	%	NN
cord-016300-vw11c2wt	127	21	in	in	IN
cord-016300-vw11c2wt	127	22	the	the	DT
cord-016300-vw11c2wt	127	23	highest	high	JJS
cord-016300-vw11c2wt	127	24	and	and	CC
cord-016300-vw11c2wt	127	25	0.43	0.43	CD
cord-016300-vw11c2wt	127	26	%	%	NN
cord-016300-vw11c2wt	127	27	in	in	IN
cord-016300-vw11c2wt	127	28	the	the	DT
cord-016300-vw11c2wt	127	29	lowest	low	JJS
cord-016300-vw11c2wt	127	30	quintile	quintile	NN
cord-016300-vw11c2wt	127	31	.	.	.
cord-016300-vw11c2wt	128	1	However	however	RB
cord-016300-vw11c2wt	128	2	,	,	,
cord-016300-vw11c2wt	128	3	respiratory	respiratory	JJ
cord-016300-vw11c2wt	128	4	causes	cause	NNS
cord-016300-vw11c2wt	128	5	of	of	IN
cord-016300-vw11c2wt	128	6	mortality	mortality	NN
cord-016300-vw11c2wt	128	7	are	be	VBP
cord-016300-vw11c2wt	128	8	not	not	RB
cord-016300-vw11c2wt	128	9	significantly	significantly	RB
cord-016300-vw11c2wt	128	10	related	relate	VBN
cord-016300-vw11c2wt	128	11	to	to	IN
cord-016300-vw11c2wt	128	12	CRP	crp	NN
cord-016300-vw11c2wt	128	13	levels	level	NNS
cord-016300-vw11c2wt	128	14	.	.	.
cord-016300-vw11c2wt	129	1	Genome	genome	NN
cord-016300-vw11c2wt	129	2	-	-	HYPH
cord-016300-vw11c2wt	129	3	wide	wide	JJ
cord-016300-vw11c2wt	129	4	expression	expression	NN
cord-016300-vw11c2wt	129	5	profiling	profiling	NN
cord-016300-vw11c2wt	129	6	of	of	IN
cord-016300-vw11c2wt	129	7	peripheral	peripheral	JJ
cord-016300-vw11c2wt	129	8	blood	blood	NN
cord-016300-vw11c2wt	129	9	samples	sample	NNS
cord-016300-vw11c2wt	129	10	from	from	IN
cord-016300-vw11c2wt	129	11	subjects	subject	NNS
cord-016300-vw11c2wt	129	12	with	with	IN
cord-016300-vw11c2wt	129	13	significant	significant	JJ
cord-016300-vw11c2wt	129	14	airflow	airflow	NN
cord-016300-vw11c2wt	129	15	obstruction	obstruction	NN
cord-016300-vw11c2wt	129	16	was	be	VBD
cord-016300-vw11c2wt	129	17	performed	perform	VBN
cord-016300-vw11c2wt	129	18	to	to	TO
cord-016300-vw11c2wt	129	19	find	find	VB
cord-016300-vw11c2wt	129	20	non	non	JJ
cord-016300-vw11c2wt	129	21	-	-	JJ
cord-016300-vw11c2wt	129	22	invasive	invasive	JJ
cord-016300-vw11c2wt	129	23	gene	gene	NN
cord-016300-vw11c2wt	129	24	expression	expression	NN
cord-016300-vw11c2wt	129	25	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	129	26	for	for	IN
cord-016300-vw11c2wt	129	27	COPD	COPD	NNP
cord-016300-vw11c2wt	129	28	(	(	-LRB-
cord-016300-vw11c2wt	129	29	Bhattacharya	Bhattacharya	NNP
cord-016300-vw11c2wt	129	30	et	et	NNP
cord-016300-vw11c2wt	129	31	al	al	NNP
cord-016300-vw11c2wt	129	32	.	.	NNP
cord-016300-vw11c2wt	129	33	2011	2011	CD
cord-016300-vw11c2wt	129	34	)	)	-RRB-
cord-016300-vw11c2wt	129	35	.	.	.
cord-016300-vw11c2wt	130	1	Correlation	correlation	NN
cord-016300-vw11c2wt	130	2	of	of	IN
cord-016300-vw11c2wt	130	3	gene	gene	NN
cord-016300-vw11c2wt	130	4	expression	expression	NN
cord-016300-vw11c2wt	130	5	with	with	IN
cord-016300-vw11c2wt	130	6	lung	lung	NN
cord-016300-vw11c2wt	130	7	function	function	NN
cord-016300-vw11c2wt	130	8	measurements	measurement	NNS
cord-016300-vw11c2wt	130	9	identified	identify	VBD
cord-016300-vw11c2wt	130	10	a	a	DT
cord-016300-vw11c2wt	130	11	set	set	NN
cord-016300-vw11c2wt	130	12	of	of	IN
cord-016300-vw11c2wt	130	13	86	86	CD
cord-016300-vw11c2wt	130	14	genes	gene	NNS
cord-016300-vw11c2wt	130	15	.	.	.
cord-016300-vw11c2wt	131	1	A	a	DT
cord-016300-vw11c2wt	131	2	total	total	NN
cord-016300-vw11c2wt	131	3	of	of	IN
cord-016300-vw11c2wt	131	4	16	16	CD
cord-016300-vw11c2wt	131	5	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	131	6	showed	show	VBD
cord-016300-vw11c2wt	131	7	evidence	evidence	NN
cord-016300-vw11c2wt	131	8	of	of	IN
cord-016300-vw11c2wt	131	9	significant	significant	JJ
cord-016300-vw11c2wt	131	10	correlation	correlation	NN
cord-016300-vw11c2wt	131	11	with	with	IN
cord-016300-vw11c2wt	131	12	quantitative	quantitative	JJ
cord-016300-vw11c2wt	131	13	traits	trait	NNS
cord-016300-vw11c2wt	131	14	and	and	CC
cord-016300-vw11c2wt	131	15	differential	differential	JJ
cord-016300-vw11c2wt	131	16	expression	expression	NN
cord-016300-vw11c2wt	131	17	between	between	IN
cord-016300-vw11c2wt	131	18	cases	case	NNS
cord-016300-vw11c2wt	131	19	and	and	CC
cord-016300-vw11c2wt	131	20	controls	control	NNS
cord-016300-vw11c2wt	131	21	.	.	.
cord-016300-vw11c2wt	132	1	Further	further	JJ
cord-016300-vw11c2wt	132	2	comparison	comparison	NN
cord-016300-vw11c2wt	132	3	of	of	IN
cord-016300-vw11c2wt	132	4	these	these	DT
cord-016300-vw11c2wt	132	5	peripheral	peripheral	JJ
cord-016300-vw11c2wt	132	6	gene	gene	NN
cord-016300-vw11c2wt	132	7	expression	expression	NN
cord-016300-vw11c2wt	132	8	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	132	9	with	with	IN
cord-016300-vw11c2wt	132	10	those	those	DT
cord-016300-vw11c2wt	132	11	previously	previously	RB
cord-016300-vw11c2wt	132	12	identified	identify	VBN
cord-016300-vw11c2wt	132	13	from	from	IN
cord-016300-vw11c2wt	132	14	lung	lung	NN
cord-016300-vw11c2wt	132	15	tissue	tissue	NN
cord-016300-vw11c2wt	132	16	of	of	IN
cord-016300-vw11c2wt	132	17	the	the	DT
cord-016300-vw11c2wt	132	18	same	same	JJ
cord-016300-vw11c2wt	132	19	cohort	cohort	NN
cord-016300-vw11c2wt	132	20	revealed	reveal	VBD
cord-016300-vw11c2wt	132	21	that	that	IN
cord-016300-vw11c2wt	132	22	two	two	CD
cord-016300-vw11c2wt	132	23	genes	gene	NNS
cord-016300-vw11c2wt	132	24	,	,	,
cord-016300-vw11c2wt	132	25	RP9	RP9	NNP
cord-016300-vw11c2wt	132	26	and	and	CC
cord-016300-vw11c2wt	132	27	NAPE	NAPE	NNP
cord-016300-vw11c2wt	132	28	-	-	HYPH
cord-016300-vw11c2wt	132	29	PLD	PLD	NNP
cord-016300-vw11c2wt	132	30	,	,	,
cord-016300-vw11c2wt	132	31	were	be	VBD
cord-016300-vw11c2wt	132	32	decreased	decrease	VBN
cord-016300-vw11c2wt	132	33	in	in	IN
cord-016300-vw11c2wt	132	34	COPD	COPD	NNP
cord-016300-vw11c2wt	132	35	cases	case	NNS
cord-016300-vw11c2wt	132	36	compared	compare	VBN
cord-016300-vw11c2wt	132	37	to	to	IN
cord-016300-vw11c2wt	132	38	controls	control	NNS
cord-016300-vw11c2wt	132	39	in	in	IN
cord-016300-vw11c2wt	132	40	both	both	DT
cord-016300-vw11c2wt	132	41	lung	lung	NN
cord-016300-vw11c2wt	132	42	tissue	tissue	NN
cord-016300-vw11c2wt	132	43	and	and	CC
cord-016300-vw11c2wt	132	44	blood	blood	NN
cord-016300-vw11c2wt	132	45	.	.	.
cord-016300-vw11c2wt	133	1	These	these	DT
cord-016300-vw11c2wt	133	2	results	result	NNS
cord-016300-vw11c2wt	133	3	contribute	contribute	VBP
cord-016300-vw11c2wt	133	4	to	to	IN
cord-016300-vw11c2wt	133	5	our	-PRON-	PRP$
cord-016300-vw11c2wt	133	6	understanding	understanding	NN
cord-016300-vw11c2wt	133	7	of	of	IN
cord-016300-vw11c2wt	133	8	gene	gene	NN
cord-016300-vw11c2wt	133	9	expression	expression	NN
cord-016300-vw11c2wt	133	10	changes	change	NNS
cord-016300-vw11c2wt	133	11	in	in	IN
cord-016300-vw11c2wt	133	12	the	the	DT
cord-016300-vw11c2wt	133	13	peripheral	peripheral	JJ
cord-016300-vw11c2wt	133	14	blood	blood	NN
cord-016300-vw11c2wt	133	15	of	of	IN
cord-016300-vw11c2wt	133	16	patients	patient	NNS
cord-016300-vw11c2wt	133	17	with	with	IN
cord-016300-vw11c2wt	133	18	COPD	COPD	NNP
cord-016300-vw11c2wt	133	19	and	and	CC
cord-016300-vw11c2wt	133	20	may	may	MD
cord-016300-vw11c2wt	133	21	provide	provide	VB
cord-016300-vw11c2wt	133	22	insight	insight	NN
cord-016300-vw11c2wt	133	23	into	into	IN
cord-016300-vw11c2wt	133	24	potential	potential	JJ
cord-016300-vw11c2wt	133	25	mechanisms	mechanism	NNS
cord-016300-vw11c2wt	133	26	involved	involve	VBN
cord-016300-vw11c2wt	133	27	in	in	IN
cord-016300-vw11c2wt	133	28	the	the	DT
cord-016300-vw11c2wt	133	29	disease	disease	NN
cord-016300-vw11c2wt	133	30	.	.	.
cord-016300-vw11c2wt	134	1	Patients	patient	NNS
cord-016300-vw11c2wt	134	2	with	with	IN
cord-016300-vw11c2wt	134	3	COPD	COPD	NNP
cord-016300-vw11c2wt	134	4	are	be	VBP
cord-016300-vw11c2wt	134	5	often	often	RB
cord-016300-vw11c2wt	134	6	at	at	IN
cord-016300-vw11c2wt	134	7	high	high	JJ
cord-016300-vw11c2wt	134	8	risk	risk	NN
cord-016300-vw11c2wt	134	9	of	of	IN
cord-016300-vw11c2wt	134	10	early	early	JJ
cord-016300-vw11c2wt	134	11	death	death	NN
cord-016300-vw11c2wt	134	12	and	and	CC
cord-016300-vw11c2wt	134	13	identification	identification	NN
cord-016300-vw11c2wt	134	14	of	of	IN
cord-016300-vw11c2wt	134	15	prognostic	prognostic	JJ
cord-016300-vw11c2wt	134	16	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	134	17	may	may	MD
cord-016300-vw11c2wt	134	18	aid	aid	VB
cord-016300-vw11c2wt	134	19	in	in	IN
cord-016300-vw11c2wt	134	20	improving	improve	VBG
cord-016300-vw11c2wt	134	21	their	-PRON-	PRP$
cord-016300-vw11c2wt	134	22	survival	survival	NN
cord-016300-vw11c2wt	134	23	by	by	IN
cord-016300-vw11c2wt	134	24	providing	provide	VBG
cord-016300-vw11c2wt	134	25	early	early	JJ
cord-016300-vw11c2wt	134	26	intensive	intensive	JJ
cord-016300-vw11c2wt	134	27	therapy	therapy	NN
cord-016300-vw11c2wt	134	28	for	for	IN
cord-016300-vw11c2wt	134	29	high	high	JJ
cord-016300-vw11c2wt	134	30	-	-	HYPH
cord-016300-vw11c2wt	134	31	risk	risk	NN
cord-016300-vw11c2wt	134	32	patients	patient	NNS
cord-016300-vw11c2wt	134	33	.	.	.
cord-016300-vw11c2wt	135	1	A	a	DT
cord-016300-vw11c2wt	135	2	study	study	NN
cord-016300-vw11c2wt	135	3	has	have	VBZ
cord-016300-vw11c2wt	135	4	investigated	investigate	VBN
cord-016300-vw11c2wt	135	5	the	the	DT
cord-016300-vw11c2wt	135	6	prognostic	prognostic	JJ
cord-016300-vw11c2wt	135	7	role	role	NN
cord-016300-vw11c2wt	135	8	of	of	IN
cord-016300-vw11c2wt	135	9	hyperuricemia	hyperuricemia	NN
cord-016300-vw11c2wt	135	10	at	at	IN
cord-016300-vw11c2wt	135	11	baseline	baseline	NN
cord-016300-vw11c2wt	135	12	on	on	IN
cord-016300-vw11c2wt	135	13	the	the	DT
cord-016300-vw11c2wt	135	14	prognosis	prognosis	NN
cord-016300-vw11c2wt	135	15	of	of	IN
cord-016300-vw11c2wt	135	16	patients	patient	NNS
cord-016300-vw11c2wt	135	17	with	with	IN
cord-016300-vw11c2wt	135	18	COPD	COPD	NNP
cord-016300-vw11c2wt	135	19	by	by	IN
cord-016300-vw11c2wt	135	20	retrospective	retrospective	JJ
cord-016300-vw11c2wt	135	21	evaluation	evaluation	NN
cord-016300-vw11c2wt	135	22	of	of	IN
cord-016300-vw11c2wt	135	23	data	datum	NNS
cord-016300-vw11c2wt	135	24	.	.	.
cord-016300-vw11c2wt	136	1	Hyperuricemia	Hyperuricemia	NNP
cord-016300-vw11c2wt	136	2	was	be	VBD
cord-016300-vw11c2wt	136	3	found	find	VBN
cord-016300-vw11c2wt	136	4	to	to	TO
cord-016300-vw11c2wt	136	5	be	be	VB
cord-016300-vw11c2wt	136	6	not	not	RB
cord-016300-vw11c2wt	136	7	associated	associate	VBN
cord-016300-vw11c2wt	136	8	with	with	IN
cord-016300-vw11c2wt	136	9	other	other	JJ
cord-016300-vw11c2wt	136	10	baseline	baseline	JJ
cord-016300-vw11c2wt	136	11	characteristics	characteristic	NNS
cord-016300-vw11c2wt	136	12	in	in	IN
cord-016300-vw11c2wt	136	13	patients	patient	NNS
cord-016300-vw11c2wt	136	14	with	with	IN
cord-016300-vw11c2wt	136	15	COPD	COPD	NNP
cord-016300-vw11c2wt	136	16	.	.	.
cord-016300-vw11c2wt	137	1	Kaplan	Kaplan	NNP
cord-016300-vw11c2wt	137	2	-	-	HYPH
cord-016300-vw11c2wt	137	3	Meier	Meier	NNP
cord-016300-vw11c2wt	137	4	survival	survival	NN
cord-016300-vw11c2wt	137	5	curve	curve	NN
cord-016300-vw11c2wt	137	6	showed	show	VBD
cord-016300-vw11c2wt	137	7	that	that	IN
cord-016300-vw11c2wt	137	8	patients	patient	NNS
cord-016300-vw11c2wt	137	9	with	with	IN
cord-016300-vw11c2wt	137	10	COPD	COPD	NNP
cord-016300-vw11c2wt	137	11	with	with	IN
cord-016300-vw11c2wt	137	12	hyperuricemia	hyperuricemia	NN
cord-016300-vw11c2wt	137	13	had	have	VBD
cord-016300-vw11c2wt	137	14	higher	high	JJR
cord-016300-vw11c2wt	137	15	risk	risk	NN
cord-016300-vw11c2wt	137	16	of	of	IN
cord-016300-vw11c2wt	137	17	mortality	mortality	NN
cord-016300-vw11c2wt	137	18	compared	compare	VBN
cord-016300-vw11c2wt	137	19	with	with	IN
cord-016300-vw11c2wt	137	20	patients	patient	NNS
cord-016300-vw11c2wt	137	21	with	with	IN
cord-016300-vw11c2wt	137	22	normouricemia	normouricemia	NN
cord-016300-vw11c2wt	137	23	.	.	.
cord-016300-vw11c2wt	138	1	Thus	thus	RB
cord-016300-vw11c2wt	138	2	,	,	,
cord-016300-vw11c2wt	138	3	hyperuricemia	hyperuricemia	NNP
cord-016300-vw11c2wt	138	4	is	be	VBZ
cord-016300-vw11c2wt	138	5	a	a	DT
cord-016300-vw11c2wt	138	6	promising	promising	JJ
cord-016300-vw11c2wt	138	7	biomarker	biomarker	NN
cord-016300-vw11c2wt	138	8	of	of	IN
cord-016300-vw11c2wt	138	9	early	early	JJ
cord-016300-vw11c2wt	138	10	mortality	mortality	NN
cord-016300-vw11c2wt	138	11	in	in	IN
cord-016300-vw11c2wt	138	12	patients	patient	NNS
cord-016300-vw11c2wt	138	13	with	with	IN
cord-016300-vw11c2wt	138	14	COPD	COPD	NNP
cord-016300-vw11c2wt	138	15	.	.	.
cord-016300-vw11c2wt	139	1	Decreased	decrease	VBN
cord-016300-vw11c2wt	139	2	expression	expression	NN
cord-016300-vw11c2wt	139	3	of	of	IN
cord-016300-vw11c2wt	139	4	vascular	vascular	JJ
cord-016300-vw11c2wt	139	5	endothelial	endothelial	JJ
cord-016300-vw11c2wt	139	6	growth	growth	NN
cord-016300-vw11c2wt	139	7	factor	factor	NN
cord-016300-vw11c2wt	139	8	(	(	-LRB-
cord-016300-vw11c2wt	139	9	VEGF	VEGF	NNP
cord-016300-vw11c2wt	139	10	)	)	-RRB-
cord-016300-vw11c2wt	139	11	and	and	CC
cord-016300-vw11c2wt	139	12	its	-PRON-	PRP$
cord-016300-vw11c2wt	139	13	receptor	receptor	NN
cord-016300-vw11c2wt	139	14	has	have	VBZ
cord-016300-vw11c2wt	139	15	been	be	VBN
cord-016300-vw11c2wt	139	16	implicated	implicate	VBN
cord-016300-vw11c2wt	139	17	in	in	IN
cord-016300-vw11c2wt	139	18	the	the	DT
cord-016300-vw11c2wt	139	19	pathogenesis	pathogenesis	NN
cord-016300-vw11c2wt	139	20	of	of	IN
cord-016300-vw11c2wt	139	21	COPD	COPD	NNP
cord-016300-vw11c2wt	139	22	.	.	.
cord-016300-vw11c2wt	140	1	Levels	level	NNS
cord-016300-vw11c2wt	140	2	of	of	IN
cord-016300-vw11c2wt	140	3	placenta	placenta	NN
cord-016300-vw11c2wt	140	4	growth	growth	NN
cord-016300-vw11c2wt	140	5	factor	factor	NN
cord-016300-vw11c2wt	140	6	(	(	-LRB-
cord-016300-vw11c2wt	140	7	PlGF	PlGF	NNP
cord-016300-vw11c2wt	140	8	)	)	-RRB-
cord-016300-vw11c2wt	140	9	,	,	,
cord-016300-vw11c2wt	140	10	another	another	DT
cord-016300-vw11c2wt	140	11	angiogenic	angiogenic	JJ
cord-016300-vw11c2wt	140	12	factor	factor	NN
cord-016300-vw11c2wt	140	13	,	,	,
cord-016300-vw11c2wt	140	14	are	be	VBP
cord-016300-vw11c2wt	140	15	increased	increase	VBN
cord-016300-vw11c2wt	140	16	in	in	IN
cord-016300-vw11c2wt	140	17	the	the	DT
cord-016300-vw11c2wt	140	18	serum	serum	NN
cord-016300-vw11c2wt	140	19	and	and	CC
cord-016300-vw11c2wt	140	20	bronchoalveolar	bronchoalveolar	NNP
cord-016300-vw11c2wt	140	21	lavage	lavage	NNP
cord-016300-vw11c2wt	140	22	(	(	-LRB-
cord-016300-vw11c2wt	140	23	BAL	BAL	NNP
cord-016300-vw11c2wt	140	24	)	)	-RRB-
cord-016300-vw11c2wt	140	25	fluid	fluid	NN
cord-016300-vw11c2wt	140	26	of	of	IN
cord-016300-vw11c2wt	140	27	patients	patient	NNS
cord-016300-vw11c2wt	140	28	with	with	IN
cord-016300-vw11c2wt	140	29	COPD	COPD	NNP
cord-016300-vw11c2wt	140	30	and	and	CC
cord-016300-vw11c2wt	140	31	are	be	VBP
cord-016300-vw11c2wt	140	32	inversely	inversely	RB
cord-016300-vw11c2wt	140	33	correlated	correlate	VBN
cord-016300-vw11c2wt	140	34	with	with	IN
cord-016300-vw11c2wt	140	35	FEV1	FEV1	NNP
cord-016300-vw11c2wt	140	36	(	(	-LRB-
cord-016300-vw11c2wt	140	37	Cheng	Cheng	NNP
cord-016300-vw11c2wt	140	38	et	et	NNP
cord-016300-vw11c2wt	140	39	al	al	NNP
cord-016300-vw11c2wt	140	40	.	.	NNP
cord-016300-vw11c2wt	140	41	2008	2008	CD
cord-016300-vw11c2wt	140	42	)	)	-RRB-
cord-016300-vw11c2wt	140	43	.	.	.
cord-016300-vw11c2wt	141	1	Serum	serum	NN
cord-016300-vw11c2wt	141	2	levels	level	NNS
cord-016300-vw11c2wt	141	3	of	of	IN
cord-016300-vw11c2wt	141	4	PlGF	plgf	NN
cord-016300-vw11c2wt	141	5	in	in	IN
cord-016300-vw11c2wt	141	6	patients	patient	NNS
cord-016300-vw11c2wt	141	7	with	with	IN
cord-016300-vw11c2wt	141	8	COPD	COPD	NNP
cord-016300-vw11c2wt	141	9	were	be	VBD
cord-016300-vw11c2wt	141	10	more	more	JJR
cord-016300-vw11c2wt	141	11	than	than	IN
cord-016300-vw11c2wt	141	12	double	double	PDT
cord-016300-vw11c2wt	141	13	those	those	DT
cord-016300-vw11c2wt	141	14	in	in	IN
cord-016300-vw11c2wt	141	15	smokers	smoker	NNS
cord-016300-vw11c2wt	141	16	and	and	CC
cord-016300-vw11c2wt	141	17	nonsmokers	nonsmoker	NNS
cord-016300-vw11c2wt	141	18	without	without	IN
cord-016300-vw11c2wt	141	19	COPD	COPD	NNP
cord-016300-vw11c2wt	141	20	.	.	.
cord-016300-vw11c2wt	142	1	These	these	DT
cord-016300-vw11c2wt	142	2	findings	finding	NNS
cord-016300-vw11c2wt	142	3	suggest	suggest	VBP
cord-016300-vw11c2wt	142	4	that	that	IN
cord-016300-vw11c2wt	142	5	bronchial	bronchial	JJ
cord-016300-vw11c2wt	142	6	epithelial	epithelial	JJ
cord-016300-vw11c2wt	142	7	cells	cell	NNS
cord-016300-vw11c2wt	142	8	can	can	MD
cord-016300-vw11c2wt	142	9	express	express	VB
cord-016300-vw11c2wt	142	10	PlGF	PlGF	NNP
cord-016300-vw11c2wt	142	11	,	,	,
cord-016300-vw11c2wt	142	12	which	which	WDT
cord-016300-vw11c2wt	142	13	may	may	MD
cord-016300-vw11c2wt	142	14	contribute	contribute	VB
cord-016300-vw11c2wt	142	15	to	to	IN
cord-016300-vw11c2wt	142	16	the	the	DT
cord-016300-vw11c2wt	142	17	pathogenesis	pathogenesis	NN
cord-016300-vw11c2wt	142	18	of	of	IN
cord-016300-vw11c2wt	142	19	COPD	COPD	NNP
cord-016300-vw11c2wt	142	20	.	.	.
cord-016300-vw11c2wt	143	1	Both	both	DT
cord-016300-vw11c2wt	143	2	PlGF	plgf	NN
cord-016300-vw11c2wt	143	3	and	and	CC
cord-016300-vw11c2wt	143	4	VEGF	VEGF	NNP
cord-016300-vw11c2wt	143	5	expression	expression	NN
cord-016300-vw11c2wt	143	6	levels	level	NNS
cord-016300-vw11c2wt	143	7	were	be	VBD
cord-016300-vw11c2wt	143	8	increased	increase	VBN
cord-016300-vw11c2wt	143	9	in	in	IN
cord-016300-vw11c2wt	143	10	cultured	cultured	JJ
cord-016300-vw11c2wt	143	11	bronchial	bronchial	JJ
cord-016300-vw11c2wt	143	12	epithelial	epithelial	JJ
cord-016300-vw11c2wt	143	13	cells	cell	NNS
cord-016300-vw11c2wt	143	14	exposed	expose	VBN
cord-016300-vw11c2wt	143	15	to	to	IN
cord-016300-vw11c2wt	143	16	pro	pro	JJ
cord-016300-vw11c2wt	143	17	-	-	JJ
cord-016300-vw11c2wt	143	18	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	143	19	cytokines	cytokine	NNS
cord-016300-vw11c2wt	143	20	such	such	JJ
cord-016300-vw11c2wt	143	21	as	as	IN
cord-016300-vw11c2wt	143	22	TNFα	TNFα	NNS
cord-016300-vw11c2wt	143	23	and	and	CC
cord-016300-vw11c2wt	143	24	IL-8	IL-8	NNP
cord-016300-vw11c2wt	143	25	.	.	.
cord-016300-vw11c2wt	144	1	Although	although	IN
cord-016300-vw11c2wt	144	2	the	the	DT
cord-016300-vw11c2wt	144	3	mechanisms	mechanism	NNS
cord-016300-vw11c2wt	144	4	underlying	underlie	VBG
cord-016300-vw11c2wt	144	5	the	the	DT
cord-016300-vw11c2wt	144	6	observed	observed	JJ
cord-016300-vw11c2wt	144	7	detrimental	detrimental	JJ
cord-016300-vw11c2wt	144	8	effects	effect	NNS
cord-016300-vw11c2wt	144	9	of	of	IN
cord-016300-vw11c2wt	144	10	PlGF	plgf	NN
cord-016300-vw11c2wt	144	11	remain	remain	VBP
cord-016300-vw11c2wt	144	12	to	to	TO
cord-016300-vw11c2wt	144	13	be	be	VB
cord-016300-vw11c2wt	144	14	clarified	clarify	VBN
cord-016300-vw11c2wt	144	15	,	,	,
cord-016300-vw11c2wt	144	16	persistent	persistent	JJ
cord-016300-vw11c2wt	144	17	PlGF	plgf	JJ
cord-016300-vw11c2wt	144	18	expression	expression	NN
cord-016300-vw11c2wt	144	19	might	may	MD
cord-016300-vw11c2wt	144	20	have	have	VB
cord-016300-vw11c2wt	144	21	adverse	adverse	JJ
cord-016300-vw11c2wt	144	22	effects	effect	NNS
cord-016300-vw11c2wt	144	23	on	on	IN
cord-016300-vw11c2wt	144	24	lung	lung	NN
cord-016300-vw11c2wt	144	25	parenchyma	parenchyma	NNS
cord-016300-vw11c2wt	144	26	by	by	IN
cord-016300-vw11c2wt	144	27	down	down	NN
cord-016300-vw11c2wt	144	28	-	-	HYPH
cord-016300-vw11c2wt	144	29	regulating	regulate	VBG
cord-016300-vw11c2wt	144	30	angiogenesis	angiogenesis	NN
cord-016300-vw11c2wt	144	31	.	.	.
cord-016300-vw11c2wt	145	1	Although	although	IN
cord-016300-vw11c2wt	145	2	the	the	DT
cord-016300-vw11c2wt	145	3	aim	aim	NN
cord-016300-vw11c2wt	145	4	of	of	IN
cord-016300-vw11c2wt	145	5	management	management	NN
cord-016300-vw11c2wt	145	6	of	of	IN
cord-016300-vw11c2wt	145	7	patients	patient	NNS
cord-016300-vw11c2wt	145	8	with	with	IN
cord-016300-vw11c2wt	145	9	asthma	asthma	NN
cord-016300-vw11c2wt	145	10	is	be	VBZ
cord-016300-vw11c2wt	145	11	to	to	TO
cord-016300-vw11c2wt	145	12	control	control	VB
cord-016300-vw11c2wt	145	13	their	-PRON-	PRP$
cord-016300-vw11c2wt	145	14	symptoms	symptom	NNS
cord-016300-vw11c2wt	145	15	and	and	CC
cord-016300-vw11c2wt	145	16	prevent	prevent	VB
cord-016300-vw11c2wt	145	17	exacerbations	exacerbation	NNS
cord-016300-vw11c2wt	145	18	and	and	CC
cord-016300-vw11c2wt	145	19	morbidity	morbidity	NN
cord-016300-vw11c2wt	145	20	of	of	IN
cord-016300-vw11c2wt	145	21	the	the	DT
cord-016300-vw11c2wt	145	22	disease	disease	NN
cord-016300-vw11c2wt	145	23	,	,	,
cord-016300-vw11c2wt	145	24	optimal	optimal	JJ
cord-016300-vw11c2wt	145	25	management	management	NN
cord-016300-vw11c2wt	145	26	may	may	MD
cord-016300-vw11c2wt	145	27	require	require	VB
cord-016300-vw11c2wt	145	28	assessment	assessment	NN
cord-016300-vw11c2wt	145	29	and	and	CC
cord-016300-vw11c2wt	145	30	monitoring	monitoring	NN
cord-016300-vw11c2wt	145	31	of	of	IN
cord-016300-vw11c2wt	145	32	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	145	33	,	,	,
cord-016300-vw11c2wt	145	34	i.e.	i.e.	FW
cord-016300-vw11c2wt	145	35	,	,	,
cord-016300-vw11c2wt	145	36	objective	objective	JJ
cord-016300-vw11c2wt	145	37	measures	measure	NNS
cord-016300-vw11c2wt	145	38	of	of	IN
cord-016300-vw11c2wt	145	39	lung	lung	NN
cord-016300-vw11c2wt	145	40	dysfunction	dysfunction	NN
cord-016300-vw11c2wt	145	41	and	and	CC
cord-016300-vw11c2wt	145	42	inflammation	inflammation	NN
cord-016300-vw11c2wt	145	43	.	.	.
cord-016300-vw11c2wt	146	1	Clinical	clinical	JJ
cord-016300-vw11c2wt	146	2	observations	observation	NNS
cord-016300-vw11c2wt	146	3	suggest	suggest	VBP
cord-016300-vw11c2wt	146	4	that	that	IN
cord-016300-vw11c2wt	146	5	rhinovirus	rhinovirus	NN
cord-016300-vw11c2wt	146	6	infection	infection	NN
cord-016300-vw11c2wt	146	7	induces	induce	VBZ
cord-016300-vw11c2wt	146	8	a	a	DT
cord-016300-vw11c2wt	146	9	specific	specific	JJ
cord-016300-vw11c2wt	146	10	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	146	11	response	response	NN
cord-016300-vw11c2wt	146	12	in	in	IN
cord-016300-vw11c2wt	146	13	predisposed	predisposed	JJ
cord-016300-vw11c2wt	146	14	individuals	individual	NNS
cord-016300-vw11c2wt	146	15	that	that	WDT
cord-016300-vw11c2wt	146	16	results	result	NNS
cord-016300-vw11c2wt	146	17	in	in	IN
cord-016300-vw11c2wt	146	18	worsened	worsen	VBN
cord-016300-vw11c2wt	146	19	asthmatic	asthmatic	JJ
cord-016300-vw11c2wt	146	20	symptoms	symptom	NNS
cord-016300-vw11c2wt	146	21	and	and	CC
cord-016300-vw11c2wt	146	22	increased	increase	VBN
cord-016300-vw11c2wt	146	23	airway	airway	NN
cord-016300-vw11c2wt	146	24	inflammation	inflammation	NN
cord-016300-vw11c2wt	146	25	.	.	.
cord-016300-vw11c2wt	147	1	A	a	DT
cord-016300-vw11c2wt	147	2	study	study	NN
cord-016300-vw11c2wt	147	3	has	have	VBZ
cord-016300-vw11c2wt	147	4	shown	show	VBN
cord-016300-vw11c2wt	147	5	that	that	IN
cord-016300-vw11c2wt	147	6	IFN	IFN	NNP
cord-016300-vw11c2wt	147	7	-	-	HYPH
cord-016300-vw11c2wt	147	8	γinduced	γinduce	VBN
cord-016300-vw11c2wt	147	9	protein	protein	NN
cord-016300-vw11c2wt	148	1	(	(	-LRB-
cord-016300-vw11c2wt	148	2	IP)-10	IP)-10	NNP
cord-016300-vw11c2wt	148	3	is	be	VBZ
cord-016300-vw11c2wt	148	4	specifically	specifically	RB
cord-016300-vw11c2wt	148	5	released	release	VBN
cord-016300-vw11c2wt	148	6	in	in	IN
cord-016300-vw11c2wt	148	7	acute	acute	JJ
cord-016300-vw11c2wt	148	8	virus	virus	NN
cord-016300-vw11c2wt	148	9	-	-	HYPH
cord-016300-vw11c2wt	148	10	induced	induce	VBN
cord-016300-vw11c2wt	148	11	asthma	asthma	NN
cord-016300-vw11c2wt	148	12	,	,	,
cord-016300-vw11c2wt	148	13	and	and	CC
cord-016300-vw11c2wt	148	14	can	can	MD
cord-016300-vw11c2wt	148	15	be	be	VB
cord-016300-vw11c2wt	148	16	measured	measure	VBN
cord-016300-vw11c2wt	148	17	in	in	IN
cord-016300-vw11c2wt	148	18	the	the	DT
cord-016300-vw11c2wt	148	19	serum	serum	NN
cord-016300-vw11c2wt	148	20	to	to	TO
cord-016300-vw11c2wt	148	21	predict	predict	VB
cord-016300-vw11c2wt	148	22	a	a	DT
cord-016300-vw11c2wt	148	23	viral	viral	JJ
cord-016300-vw11c2wt	148	24	trigger	trigger	NN
cord-016300-vw11c2wt	148	25	of	of	IN
cord-016300-vw11c2wt	148	26	acute	acute	JJ
cord-016300-vw11c2wt	148	27	exacerbations	exacerbation	NNS
cord-016300-vw11c2wt	148	28	(	(	-LRB-
cord-016300-vw11c2wt	148	29	Wark	Wark	NNP
cord-016300-vw11c2wt	148	30	et	et	FW
cord-016300-vw11c2wt	148	31	al	al	NNP
cord-016300-vw11c2wt	148	32	.	.	NNP
cord-016300-vw11c2wt	148	33	2007	2007	CD
cord-016300-vw11c2wt	148	34	)	)	-RRB-
cord-016300-vw11c2wt	148	35	.	.	.
cord-016300-vw11c2wt	149	1	Primary	primary	JJ
cord-016300-vw11c2wt	149	2	bronchial	bronchial	JJ
cord-016300-vw11c2wt	149	3	epithelial	epithelial	JJ
cord-016300-vw11c2wt	149	4	cell	cell	NN
cord-016300-vw11c2wt	149	5	models	model	NNS
cord-016300-vw11c2wt	149	6	of	of	IN
cord-016300-vw11c2wt	149	7	rhinovirus	rhinovirus	NN
cord-016300-vw11c2wt	149	8	infection	infection	NN
cord-016300-vw11c2wt	149	9	were	be	VBD
cord-016300-vw11c2wt	149	10	used	use	VBN
cord-016300-vw11c2wt	149	11	to	to	TO
cord-016300-vw11c2wt	149	12	identify	identify	VB
cord-016300-vw11c2wt	149	13	mediators	mediator	NNS
cord-016300-vw11c2wt	149	14	of	of	IN
cord-016300-vw11c2wt	149	15	rhinovirus	rhinovirus	NN
cord-016300-vw11c2wt	149	16	infection	infection	NN
cord-016300-vw11c2wt	149	17	and	and	CC
cord-016300-vw11c2wt	149	18	responded	respond	VBD
cord-016300-vw11c2wt	149	19	to	to	IN
cord-016300-vw11c2wt	149	20	infection	infection	NN
cord-016300-vw11c2wt	149	21	with	with	IN
cord-016300-vw11c2wt	149	22	rhinovirus-16	rhinovirus-16	NNP
cord-016300-vw11c2wt	149	23	by	by	IN
cord-016300-vw11c2wt	149	24	releasing	release	VBG
cord-016300-vw11c2wt	149	25	high	high	JJ
cord-016300-vw11c2wt	149	26	levels	level	NNS
cord-016300-vw11c2wt	149	27	of	of	IN
cord-016300-vw11c2wt	149	28	IP-10	IP-10	NNP
cord-016300-vw11c2wt	149	29	,	,	,
cord-016300-vw11c2wt	149	30	RANTES	RANTES	NNP
cord-016300-vw11c2wt	149	31	,	,	,
cord-016300-vw11c2wt	149	32	and	and	CC
cord-016300-vw11c2wt	149	33	IL-16	IL-16	NNP
cord-016300-vw11c2wt	149	34	,	,	,
cord-016300-vw11c2wt	149	35	as	as	RB
cord-016300-vw11c2wt	149	36	well	well	RB
cord-016300-vw11c2wt	149	37	as	as	IN
cord-016300-vw11c2wt	149	38	smaller	small	JJR
cord-016300-vw11c2wt	149	39	amounts	amount	NNS
cord-016300-vw11c2wt	149	40	of	of	IN
cord-016300-vw11c2wt	149	41	IL-8	IL-8	NNP
cord-016300-vw11c2wt	149	42	and	and	CC
cord-016300-vw11c2wt	149	43	TNF	TNF	NNP
cord-016300-vw11c2wt	149	44	-	-	HYPH
cord-016300-vw11c2wt	149	45	α	α	NNP
cord-016300-vw11c2wt	149	46	.	.	.
cord-016300-vw11c2wt	149	47	IP-10	IP-10	NNP
cord-016300-vw11c2wt	149	48	,	,	,
cord-016300-vw11c2wt	149	49	perhaps	perhaps	RB
cord-016300-vw11c2wt	149	50	in	in	IN
cord-016300-vw11c2wt	149	51	combination	combination	NN
cord-016300-vw11c2wt	149	52	with	with	IN
cord-016300-vw11c2wt	149	53	TNF	TNF	NNP
cord-016300-vw11c2wt	149	54	-	-	HYPH
cord-016300-vw11c2wt	149	55	α	α	NNP
cord-016300-vw11c2wt	149	56	,	,	,
cord-016300-vw11c2wt	149	57	might	may	MD
cord-016300-vw11c2wt	149	58	be	be	VB
cord-016300-vw11c2wt	149	59	a	a	DT
cord-016300-vw11c2wt	149	60	useful	useful	JJ
cord-016300-vw11c2wt	149	61	clinical	clinical	JJ
cord-016300-vw11c2wt	149	62	marker	marker	NN
cord-016300-vw11c2wt	149	63	to	to	TO
cord-016300-vw11c2wt	149	64	identify	identify	VB
cord-016300-vw11c2wt	149	65	rhinovirus	rhinovirus	NN
cord-016300-vw11c2wt	149	66	and	and	CC
cord-016300-vw11c2wt	149	67	other	other	JJ
cord-016300-vw11c2wt	149	68	virus	virus	NN
cord-016300-vw11c2wt	149	69	-	-	HYPH
cord-016300-vw11c2wt	149	70	induced	induce	VBN
cord-016300-vw11c2wt	149	71	acute	acute	JJ
cord-016300-vw11c2wt	149	72	asthma	asthma	NN
cord-016300-vw11c2wt	149	73	.	.	.
cord-016300-vw11c2wt	150	1	Additional	additional	JJ
cord-016300-vw11c2wt	150	2	findings	finding	NNS
cord-016300-vw11c2wt	150	3	suggest	suggest	VBP
cord-016300-vw11c2wt	150	4	that	that	IN
cord-016300-vw11c2wt	150	5	IP-10	IP-10	NNP
cord-016300-vw11c2wt	150	6	or	or	CC
cord-016300-vw11c2wt	150	7	CXCR3	cxcr3	XX
cord-016300-vw11c2wt	150	8	(	(	-LRB-
cord-016300-vw11c2wt	150	9	an	an	DT
cord-016300-vw11c2wt	150	10	IP-10	IP-10	NNP
cord-016300-vw11c2wt	150	11	receptor	receptor	NN
cord-016300-vw11c2wt	150	12	that	that	WDT
cord-016300-vw11c2wt	150	13	is	be	VBZ
cord-016300-vw11c2wt	150	14	highly	highly	RB
cord-016300-vw11c2wt	150	15	expressed	express	VBN
cord-016300-vw11c2wt	150	16	in	in	IN
cord-016300-vw11c2wt	150	17	activated	activate	VBN
cord-016300-vw11c2wt	150	18	T	T	NNP
cord-016300-vw11c2wt	150	19	cells	cell	NNS
cord-016300-vw11c2wt	150	20	)	)	-RRB-
cord-016300-vw11c2wt	150	21	might	may	MD
cord-016300-vw11c2wt	150	22	have	have	VB
cord-016300-vw11c2wt	150	23	a	a	DT
cord-016300-vw11c2wt	150	24	role	role	NN
cord-016300-vw11c2wt	150	25	in	in	IN
cord-016300-vw11c2wt	150	26	worsening	worsen	VBG
cord-016300-vw11c2wt	150	27	of	of	IN
cord-016300-vw11c2wt	150	28	airflow	airflow	NN
cord-016300-vw11c2wt	150	29	obstruction	obstruction	NN
cord-016300-vw11c2wt	150	30	and	and	CC
cord-016300-vw11c2wt	150	31	airway	airway	NN
cord-016300-vw11c2wt	150	32	inflammation	inflammation	NN
cord-016300-vw11c2wt	150	33	,	,	,
cord-016300-vw11c2wt	150	34	and	and	CC
cord-016300-vw11c2wt	150	35	may	may	MD
cord-016300-vw11c2wt	150	36	therefore	therefore	RB
cord-016300-vw11c2wt	150	37	be	be	VB
cord-016300-vw11c2wt	150	38	potential	potential	JJ
cord-016300-vw11c2wt	150	39	therapeutic	therapeutic	JJ
cord-016300-vw11c2wt	150	40	targets	target	NNS
cord-016300-vw11c2wt	150	41	.	.	.
cord-016300-vw11c2wt	151	1	International	international	JJ
cord-016300-vw11c2wt	151	2	guidelines	guideline	NNS
cord-016300-vw11c2wt	151	3	on	on	IN
cord-016300-vw11c2wt	151	4	the	the	DT
cord-016300-vw11c2wt	151	5	management	management	NN
cord-016300-vw11c2wt	151	6	of	of	IN
cord-016300-vw11c2wt	151	7	asthma	asthma	NNP
cord-016300-vw11c2wt	151	8	support	support	VBP
cord-016300-vw11c2wt	151	9	the	the	DT
cord-016300-vw11c2wt	151	10	early	early	JJ
cord-016300-vw11c2wt	151	11	introduction	introduction	NN
cord-016300-vw11c2wt	151	12	of	of	IN
cord-016300-vw11c2wt	151	13	corticosteroids	corticosteroid	NNS
cord-016300-vw11c2wt	151	14	to	to	TO
cord-016300-vw11c2wt	151	15	control	control	VB
cord-016300-vw11c2wt	151	16	symptoms	symptom	NNS
cord-016300-vw11c2wt	151	17	and	and	CC
cord-016300-vw11c2wt	151	18	to	to	TO
cord-016300-vw11c2wt	151	19	improve	improve	VB
cord-016300-vw11c2wt	151	20	lung	lung	NN
cord-016300-vw11c2wt	151	21	function	function	NN
cord-016300-vw11c2wt	151	22	by	by	IN
cord-016300-vw11c2wt	151	23	reducing	reduce	VBG
cord-016300-vw11c2wt	151	24	airway	airway	NN
cord-016300-vw11c2wt	151	25	inflammation	inflammation	NN
cord-016300-vw11c2wt	151	26	.	.	.
cord-016300-vw11c2wt	152	1	However	however	RB
cord-016300-vw11c2wt	152	2	,	,	,
cord-016300-vw11c2wt	152	3	not	not	RB
cord-016300-vw11c2wt	152	4	all	all	DT
cord-016300-vw11c2wt	152	5	individuals	individual	NNS
cord-016300-vw11c2wt	152	6	respond	respond	VBP
cord-016300-vw11c2wt	152	7	to	to	IN
cord-016300-vw11c2wt	152	8	corticosteroids	corticosteroid	NNS
cord-016300-vw11c2wt	152	9	to	to	IN
cord-016300-vw11c2wt	152	10	the	the	DT
cord-016300-vw11c2wt	152	11	same	same	JJ
cord-016300-vw11c2wt	152	12	extent	extent	NN
cord-016300-vw11c2wt	152	13	and	and	CC
cord-016300-vw11c2wt	152	14	it	-PRON-	PRP
cord-016300-vw11c2wt	152	15	would	would	MD
cord-016300-vw11c2wt	152	16	be	be	VB
cord-016300-vw11c2wt	152	17	an	an	DT
cord-016300-vw11c2wt	152	18	desirable	desirable	JJ
cord-016300-vw11c2wt	152	19	to	to	TO
cord-016300-vw11c2wt	152	20	be	be	VB
cord-016300-vw11c2wt	152	21	able	able	JJ
cord-016300-vw11c2wt	152	22	to	to	TO
cord-016300-vw11c2wt	152	23	predict	predict	VB
cord-016300-vw11c2wt	152	24	the	the	DT
cord-016300-vw11c2wt	152	25	response	response	NN
cord-016300-vw11c2wt	152	26	to	to	IN
cord-016300-vw11c2wt	152	27	corticosteroid	corticosteroid	NN
cord-016300-vw11c2wt	152	28	treatment	treatment	NN
cord-016300-vw11c2wt	152	29	.	.	.
cord-016300-vw11c2wt	153	1	Several	several	JJ
cord-016300-vw11c2wt	153	2	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	153	3	have	have	VBP
cord-016300-vw11c2wt	153	4	been	be	VBN
cord-016300-vw11c2wt	153	5	assessed	assess	VBN
cord-016300-vw11c2wt	153	6	following	follow	VBG
cord-016300-vw11c2wt	153	7	treatment	treatment	NN
cord-016300-vw11c2wt	153	8	with	with	IN
cord-016300-vw11c2wt	153	9	corticosteroids	corticosteroid	NNS
cord-016300-vw11c2wt	153	10	including	include	VBG
cord-016300-vw11c2wt	153	11	measures	measure	NNS
cord-016300-vw11c2wt	153	12	of	of	IN
cord-016300-vw11c2wt	153	13	lung	lung	NN
cord-016300-vw11c2wt	153	14	function	function	NN
cord-016300-vw11c2wt	153	15	,	,	,
cord-016300-vw11c2wt	153	16	peripheral	peripheral	JJ
cord-016300-vw11c2wt	153	17	blood	blood	NN
cord-016300-vw11c2wt	153	18	and	and	CC
cord-016300-vw11c2wt	153	19	sputum	sputum	NN
cord-016300-vw11c2wt	153	20	indices	index	NNS
cord-016300-vw11c2wt	153	21	of	of	IN
cord-016300-vw11c2wt	153	22	inflammation	inflammation	NN
cord-016300-vw11c2wt	153	23	,	,	,
cord-016300-vw11c2wt	153	24	exhaled	exhale	VBD
cord-016300-vw11c2wt	153	25	gases	gas	NNS
cord-016300-vw11c2wt	153	26	and	and	CC
cord-016300-vw11c2wt	153	27	breath	breath	NN
cord-016300-vw11c2wt	153	28	condensates	condensate	NNS
cord-016300-vw11c2wt	153	29	.	.	.
cord-016300-vw11c2wt	154	1	The	the	DT
cord-016300-vw11c2wt	154	2	most	most	RBS
cord-016300-vw11c2wt	154	3	widely	widely	RB
cord-016300-vw11c2wt	154	4	examined	examine	VBN
cord-016300-vw11c2wt	154	5	measures	measure	NNS
cord-016300-vw11c2wt	154	6	in	in	IN
cord-016300-vw11c2wt	154	7	predicting	predict	VBG
cord-016300-vw11c2wt	154	8	a	a	DT
cord-016300-vw11c2wt	154	9	response	response	NN
cord-016300-vw11c2wt	154	10	to	to	IN
cord-016300-vw11c2wt	154	11	corticosteroids	corticosteroid	NNS
cord-016300-vw11c2wt	154	12	are	be	VBP
cord-016300-vw11c2wt	154	13	airway	airway	NNP
cord-016300-vw11c2wt	154	14	hyperresponsiveness	hyperresponsiveness	NNP
cord-016300-vw11c2wt	154	15	,	,	,
cord-016300-vw11c2wt	154	16	exhaled	exhale	VBD
cord-016300-vw11c2wt	154	17	NO	NO	NNP
cord-016300-vw11c2wt	154	18	(	(	-LRB-
cord-016300-vw11c2wt	154	19	eNO	eno	NN
cord-016300-vw11c2wt	154	20	)	)	-RRB-
cord-016300-vw11c2wt	154	21	and	and	CC
cord-016300-vw11c2wt	154	22	induced	induce	VBN
cord-016300-vw11c2wt	154	23	sputum	sputum	NN
cord-016300-vw11c2wt	154	24	.	.	.
cord-016300-vw11c2wt	155	1	Of	of	IN
cord-016300-vw11c2wt	155	2	these	these	DT
cord-016300-vw11c2wt	155	3	,	,	,
cord-016300-vw11c2wt	155	4	sputum	sputum	NN
cord-016300-vw11c2wt	155	5	eosinophilia	eosinophilia	NN
cord-016300-vw11c2wt	155	6	has	have	VBZ
cord-016300-vw11c2wt	155	7	been	be	VBN
cord-016300-vw11c2wt	155	8	demonstrated	demonstrate	VBN
cord-016300-vw11c2wt	155	9	to	to	TO
cord-016300-vw11c2wt	155	10	be	be	VB
cord-016300-vw11c2wt	155	11	the	the	DT
cord-016300-vw11c2wt	155	12	best	good	JJS
cord-016300-vw11c2wt	155	13	predictor	predictor	NN
cord-016300-vw11c2wt	155	14	of	of	IN
cord-016300-vw11c2wt	155	15	a	a	DT
cord-016300-vw11c2wt	155	16	short	short	JJ
cord-016300-vw11c2wt	155	17	-	-	HYPH
cord-016300-vw11c2wt	155	18	term	term	NN
cord-016300-vw11c2wt	155	19	response	response	NN
cord-016300-vw11c2wt	155	20	to	to	IN
cord-016300-vw11c2wt	155	21	corticosteroids	corticosteroid	NNS
cord-016300-vw11c2wt	155	22	.	.	.
cord-016300-vw11c2wt	156	1	More	more	RBR
cord-016300-vw11c2wt	156	2	importantly	importantly	RB
cord-016300-vw11c2wt	156	3	,	,	,
cord-016300-vw11c2wt	156	4	directing	direct	VBG
cord-016300-vw11c2wt	156	5	treatment	treatment	NN
cord-016300-vw11c2wt	156	6	at	at	IN
cord-016300-vw11c2wt	156	7	normalizing	normalize	VBG
cord-016300-vw11c2wt	156	8	the	the	DT
cord-016300-vw11c2wt	156	9	sputum	sputum	NN
cord-016300-vw11c2wt	156	10	eosinophil	eosinophil	NN
cord-016300-vw11c2wt	156	11	count	count	NN
cord-016300-vw11c2wt	156	12	can	can	MD
cord-016300-vw11c2wt	156	13	substantially	substantially	RB
cord-016300-vw11c2wt	156	14	reduce	reduce	VB
cord-016300-vw11c2wt	156	15	severe	severe	JJ
cord-016300-vw11c2wt	156	16	exacerbations	exacerbation	NNS
cord-016300-vw11c2wt	156	17	.	.	.
cord-016300-vw11c2wt	157	1	The	the	DT
cord-016300-vw11c2wt	157	2	widespread	widespread	JJ
cord-016300-vw11c2wt	157	3	utilization	utilization	NN
cord-016300-vw11c2wt	157	4	of	of	IN
cord-016300-vw11c2wt	157	5	sputum	sputum	NN
cord-016300-vw11c2wt	157	6	induction	induction	NN
cord-016300-vw11c2wt	157	7	is	be	VBZ
cord-016300-vw11c2wt	157	8	hampered	hamper	VBN
cord-016300-vw11c2wt	157	9	because	because	IN
cord-016300-vw11c2wt	157	10	the	the	DT
cord-016300-vw11c2wt	157	11	procedure	procedure	NN
cord-016300-vw11c2wt	157	12	is	be	VBZ
cord-016300-vw11c2wt	157	13	relatively	relatively	RB
cord-016300-vw11c2wt	157	14	labor	labor	NN
cord-016300-vw11c2wt	157	15	intensive	intensive	JJ
cord-016300-vw11c2wt	157	16	.	.	.
cord-016300-vw11c2wt	158	1	The	the	DT
cord-016300-vw11c2wt	158	2	measurement	measurement	NN
cord-016300-vw11c2wt	158	3	of	of	IN
cord-016300-vw11c2wt	158	4	eNO	eno	NN
cord-016300-vw11c2wt	158	5	is	be	VBZ
cord-016300-vw11c2wt	158	6	simpler	simple	JJR
cord-016300-vw11c2wt	158	7	,	,	,
cord-016300-vw11c2wt	158	8	but	but	CC
cord-016300-vw11c2wt	158	9	incorporating	incorporate	VBG
cord-016300-vw11c2wt	158	10	the	the	DT
cord-016300-vw11c2wt	158	11	assessment	assessment	NN
cord-016300-vw11c2wt	158	12	of	of	IN
cord-016300-vw11c2wt	158	13	NO	no	DT
cord-016300-vw11c2wt	158	14	in	in	IN
cord-016300-vw11c2wt	158	15	an	an	DT
cord-016300-vw11c2wt	158	16	asthma	asthma	NN
cord-016300-vw11c2wt	158	17	management	management	NN
cord-016300-vw11c2wt	158	18	strategy	strategy	NN
cord-016300-vw11c2wt	158	19	has	have	VBZ
cord-016300-vw11c2wt	158	20	not	not	RB
cord-016300-vw11c2wt	158	21	led	lead	VBN
cord-016300-vw11c2wt	158	22	to	to	IN
cord-016300-vw11c2wt	158	23	a	a	DT
cord-016300-vw11c2wt	158	24	reduction	reduction	NN
cord-016300-vw11c2wt	158	25	in	in	IN
cord-016300-vw11c2wt	158	26	exacerbation	exacerbation	NN
cord-016300-vw11c2wt	158	27	rates	rate	NNS
cord-016300-vw11c2wt	158	28	.	.	.
cord-016300-vw11c2wt	159	1	The	the	DT
cord-016300-vw11c2wt	159	2	challenge	challenge	NN
cord-016300-vw11c2wt	159	3	now	now	RB
cord-016300-vw11c2wt	159	4	is	be	VBZ
cord-016300-vw11c2wt	159	5	to	to	TO
cord-016300-vw11c2wt	159	6	either	either	CC
cord-016300-vw11c2wt	159	7	simplify	simplify	VB
cord-016300-vw11c2wt	159	8	the	the	DT
cord-016300-vw11c2wt	159	9	measurement	measurement	NN
cord-016300-vw11c2wt	159	10	of	of	IN
cord-016300-vw11c2wt	159	11	a	a	DT
cord-016300-vw11c2wt	159	12	sputum	sputum	NN
cord-016300-vw11c2wt	159	13	eosinophilia	eosinophilia	NN
cord-016300-vw11c2wt	159	14	or	or	CC
cord-016300-vw11c2wt	159	15	to	to	TO
cord-016300-vw11c2wt	159	16	identify	identify	VB
cord-016300-vw11c2wt	159	17	another	another	DT
cord-016300-vw11c2wt	159	18	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	159	19	marker	marker	NN
cord-016300-vw11c2wt	159	20	with	with	IN
cord-016300-vw11c2wt	159	21	a	a	DT
cord-016300-vw11c2wt	159	22	similar	similar	JJ
cord-016300-vw11c2wt	159	23	efficacy	efficacy	NN
cord-016300-vw11c2wt	159	24	as	as	IN
cord-016300-vw11c2wt	159	25	the	the	DT
cord-016300-vw11c2wt	159	26	sputum	sputum	NN
cord-016300-vw11c2wt	159	27	eosinophil	eosinophil	NN
cord-016300-vw11c2wt	159	28	count	count	NN
cord-016300-vw11c2wt	159	29	in	in	IN
cord-016300-vw11c2wt	159	30	predicting	predict	VBG
cord-016300-vw11c2wt	159	31	both	both	CC
cord-016300-vw11c2wt	159	32	the	the	DT
cord-016300-vw11c2wt	159	33	short	short	JJ
cord-016300-vw11c2wt	159	34	-	-	HYPH
cord-016300-vw11c2wt	159	35	and	and	CC
cord-016300-vw11c2wt	159	36	long	long	JJ
cord-016300-vw11c2wt	159	37	-	-	HYPH
cord-016300-vw11c2wt	159	38	term	term	NN
cord-016300-vw11c2wt	159	39	responses	response	NNS
cord-016300-vw11c2wt	159	40	to	to	IN
cord-016300-vw11c2wt	159	41	corticosteroids	corticosteroid	NNS
cord-016300-vw11c2wt	159	42	.	.	.
cord-016300-vw11c2wt	160	1	Airway	airway	JJ
cord-016300-vw11c2wt	160	2	inflammation	inflammation	NN
cord-016300-vw11c2wt	160	3	is	be	VBZ
cord-016300-vw11c2wt	160	4	associated	associate	VBN
cord-016300-vw11c2wt	160	5	with	with	IN
cord-016300-vw11c2wt	160	6	an	an	DT
cord-016300-vw11c2wt	160	7	increased	increase	VBN
cord-016300-vw11c2wt	160	8	expression	expression	NN
cord-016300-vw11c2wt	160	9	and	and	CC
cord-016300-vw11c2wt	160	10	release	release	NN
cord-016300-vw11c2wt	160	11	of	of	IN
cord-016300-vw11c2wt	160	12	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	160	13	reactants	reactant	NNS
cord-016300-vw11c2wt	160	14	that	that	WDT
cord-016300-vw11c2wt	160	15	regulate	regulate	VBP
cord-016300-vw11c2wt	160	16	processes	process	NNS
cord-016300-vw11c2wt	160	17	of	of	IN
cord-016300-vw11c2wt	160	18	cell	cell	NN
cord-016300-vw11c2wt	160	19	migration	migration	NN
cord-016300-vw11c2wt	160	20	,	,	,
cord-016300-vw11c2wt	160	21	activation	activation	NN
cord-016300-vw11c2wt	160	22	and	and	CC
cord-016300-vw11c2wt	160	23	degranulation	degranulation	NN
cord-016300-vw11c2wt	160	24	.	.	.
cord-016300-vw11c2wt	161	1	One	one	CD
cord-016300-vw11c2wt	161	2	study	study	NN
cord-016300-vw11c2wt	161	3	was	be	VBD
cord-016300-vw11c2wt	161	4	done	do	VBN
cord-016300-vw11c2wt	161	5	to	to	TO
cord-016300-vw11c2wt	161	6	quantify	quantify	VB
cord-016300-vw11c2wt	161	7	bronchial	bronchial	JJ
cord-016300-vw11c2wt	161	8	lavage	lavage	NN
cord-016300-vw11c2wt	161	9	(	(	-LRB-
cord-016300-vw11c2wt	161	10	BAL	BAL	NNP
cord-016300-vw11c2wt	161	11	)	)	-RRB-
cord-016300-vw11c2wt	161	12	fluid	fluid	NN
cord-016300-vw11c2wt	161	13	and	and	CC
cord-016300-vw11c2wt	161	14	serum	serum	NN
cord-016300-vw11c2wt	161	15	levels	level	NNS
cord-016300-vw11c2wt	161	16	of	of	IN
cord-016300-vw11c2wt	161	17	IL-8	il-8	NN
cord-016300-vw11c2wt	161	18	,	,	,
cord-016300-vw11c2wt	161	19	secretory	secretory	JJ
cord-016300-vw11c2wt	161	20	leukocyte	leukocyte	NN
cord-016300-vw11c2wt	161	21	protease	protease	NN
cord-016300-vw11c2wt	161	22	inhibitor	inhibitor	NN
cord-016300-vw11c2wt	161	23	(	(	-LRB-
cord-016300-vw11c2wt	161	24	SLPI	SLPI	NNP
cord-016300-vw11c2wt	161	25	)	)	-RRB-
cord-016300-vw11c2wt	161	26	,	,	,
cord-016300-vw11c2wt	161	27	soluble	soluble	JJ
cord-016300-vw11c2wt	161	28	intracellular	intracellular	JJ
cord-016300-vw11c2wt	161	29	adhesion	adhesion	NN
cord-016300-vw11c2wt	161	30	molecules-1	molecules-1	NNP
cord-016300-vw11c2wt	161	31	(	(	-LRB-
cord-016300-vw11c2wt	161	32	sICAM-1	sICAM-1	NNP
cord-016300-vw11c2wt	161	33	)	)	-RRB-
cord-016300-vw11c2wt	161	34	and	and	CC
cord-016300-vw11c2wt	161	35	sCD14	sCD14	NNP
cord-016300-vw11c2wt	161	36	,	,	,
cord-016300-vw11c2wt	161	37	as	as	IN
cord-016300-vw11c2wt	161	38	surrogate	surrogate	JJ
cord-016300-vw11c2wt	161	39	markers	marker	NNS
cord-016300-vw11c2wt	161	40	of	of	IN
cord-016300-vw11c2wt	161	41	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	161	42	and	and	CC
cord-016300-vw11c2wt	161	43	immune	immune	JJ
cord-016300-vw11c2wt	161	44	response	response	NN
cord-016300-vw11c2wt	161	45	in	in	IN
cord-016300-vw11c2wt	161	46	asthma	asthma	NN
cord-016300-vw11c2wt	161	47	and	and	CC
cord-016300-vw11c2wt	161	48	COPD	COPD	NNP
cord-016300-vw11c2wt	161	49	patients	patient	NNS
cord-016300-vw11c2wt	161	50	with	with	IN
cord-016300-vw11c2wt	161	51	similar	similar	JJ
cord-016300-vw11c2wt	161	52	disease	disease	NN
cord-016300-vw11c2wt	161	53	duration	duration	NN
cord-016300-vw11c2wt	161	54	time	time	NN
cord-016300-vw11c2wt	161	55	(	(	-LRB-
cord-016300-vw11c2wt	161	56	Hollander	Hollander	NNP
cord-016300-vw11c2wt	161	57	et	et	NNP
cord-016300-vw11c2wt	161	58	al	al	NNP
cord-016300-vw11c2wt	161	59	.	.	NNP
cord-016300-vw11c2wt	161	60	2007	2007	CD
cord-016300-vw11c2wt	161	61	)	)	-RRB-
cord-016300-vw11c2wt	161	62	.	.	.
cord-016300-vw11c2wt	162	1	Biomarkers	biomarker	NNS
cord-016300-vw11c2wt	162	2	were	be	VBD
cord-016300-vw11c2wt	162	3	measured	measure	VBN
cord-016300-vw11c2wt	162	4	using	use	VBG
cord-016300-vw11c2wt	162	5	commercially	commercially	RB
cord-016300-vw11c2wt	162	6	available	available	JJ
cord-016300-vw11c2wt	162	7	ELISA	ELISA	NNP
cord-016300-vw11c2wt	162	8	kits	kit	NNS
cord-016300-vw11c2wt	162	9	.	.	.
cord-016300-vw11c2wt	163	1	The	the	DT
cord-016300-vw11c2wt	163	2	findings	finding	NNS
cord-016300-vw11c2wt	163	3	show	show	VBP
cord-016300-vw11c2wt	163	4	that	that	IN
cord-016300-vw11c2wt	163	5	of	of	IN
cord-016300-vw11c2wt	163	6	four	four	CD
cord-016300-vw11c2wt	163	7	measured	measure	VBN
cord-016300-vw11c2wt	163	8	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	163	9	,	,	,
cord-016300-vw11c2wt	163	10	only	only	RB
cord-016300-vw11c2wt	163	11	the	the	DT
cord-016300-vw11c2wt	163	12	BAL	bal	NN
cord-016300-vw11c2wt	163	13	IL-8	IL-8	NNP
cord-016300-vw11c2wt	163	14	was	be	VBD
cord-016300-vw11c2wt	163	15	higher	high	JJR
cord-016300-vw11c2wt	163	16	in	in	IN
cord-016300-vw11c2wt	163	17	COPD	COPD	NNP
cord-016300-vw11c2wt	163	18	patients	patient	NNS
cord-016300-vw11c2wt	163	19	when	when	WRB
cord-016300-vw11c2wt	163	20	compared	compare	VBN
cord-016300-vw11c2wt	163	21	to	to	IN
cord-016300-vw11c2wt	163	22	asthma	asthma	NN
cord-016300-vw11c2wt	163	23	.	.	.
cord-016300-vw11c2wt	164	1	Severe	severe	JJ
cord-016300-vw11c2wt	164	2	asthma	asthma	NN
cord-016300-vw11c2wt	164	3	is	be	VBZ
cord-016300-vw11c2wt	164	4	characterized	characterize	VBN
cord-016300-vw11c2wt	164	5	by	by	IN
cord-016300-vw11c2wt	164	6	elevated	elevated	JJ
cord-016300-vw11c2wt	164	7	levels	level	NNS
cord-016300-vw11c2wt	164	8	of	of	IN
cord-016300-vw11c2wt	164	9	proinflammatory	proinflammatory	JJ
cord-016300-vw11c2wt	164	10	cytokines	cytokine	NNS
cord-016300-vw11c2wt	164	11	and	and	CC
cord-016300-vw11c2wt	164	12	neutrophilic	neutrophilic	JJ
cord-016300-vw11c2wt	164	13	inflammation	inflammation	NN
cord-016300-vw11c2wt	164	14	in	in	IN
cord-016300-vw11c2wt	164	15	the	the	DT
cord-016300-vw11c2wt	164	16	airways	airway	NNS
cord-016300-vw11c2wt	164	17	.	.	.
cord-016300-vw11c2wt	165	1	Blood	blood	NN
cord-016300-vw11c2wt	165	2	cytokines	cytokine	NNS
cord-016300-vw11c2wt	165	3	,	,	,
cord-016300-vw11c2wt	165	4	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	165	5	of	of	IN
cord-016300-vw11c2wt	165	6	systemic	systemic	JJ
cord-016300-vw11c2wt	165	7	inflammation	inflammation	NN
cord-016300-vw11c2wt	165	8	,	,	,
cord-016300-vw11c2wt	165	9	may	may	MD
cord-016300-vw11c2wt	165	10	be	be	VB
cord-016300-vw11c2wt	165	11	a	a	DT
cord-016300-vw11c2wt	165	12	feature	feature	NN
cord-016300-vw11c2wt	165	13	of	of	IN
cord-016300-vw11c2wt	165	14	increased	increase	VBN
cord-016300-vw11c2wt	165	15	inflammation	inflammation	NN
cord-016300-vw11c2wt	165	16	in	in	IN
cord-016300-vw11c2wt	165	17	severe	severe	JJ
cord-016300-vw11c2wt	165	18	asthma	asthma	NN
cord-016300-vw11c2wt	165	19	.	.	.
cord-016300-vw11c2wt	166	1	One	one	CD
cord-016300-vw11c2wt	166	2	study	study	NN
cord-016300-vw11c2wt	166	3	found	find	VBD
cord-016300-vw11c2wt	166	4	that	that	IN
cord-016300-vw11c2wt	166	5	IL-8	IL-8	NNP
cord-016300-vw11c2wt	166	6	and	and	CC
cord-016300-vw11c2wt	166	7	TNF	TNF	NNP
cord-016300-vw11c2wt	166	8	-	-	HYPH
cord-016300-vw11c2wt	166	9	α	α	NN
cord-016300-vw11c2wt	166	10	levels	level	NNS
cord-016300-vw11c2wt	166	11	were	be	VBD
cord-016300-vw11c2wt	166	12	higher	high	JJR
cord-016300-vw11c2wt	166	13	in	in	IN
cord-016300-vw11c2wt	166	14	severe	severe	JJ
cord-016300-vw11c2wt	166	15	asthmatics	asthmatic	NNS
cord-016300-vw11c2wt	166	16	than	than	IN
cord-016300-vw11c2wt	166	17	in	in	IN
cord-016300-vw11c2wt	166	18	mild	mild	JJ
cord-016300-vw11c2wt	166	19	-	-	HYPH
cord-016300-vw11c2wt	166	20	moderate	moderate	JJ
cord-016300-vw11c2wt	166	21	asthmatics	asthmatic	NNS
cord-016300-vw11c2wt	166	22	or	or	CC
cord-016300-vw11c2wt	166	23	in	in	IN
cord-016300-vw11c2wt	166	24	controls	control	NNS
cord-016300-vw11c2wt	166	25	and	and	CC
cord-016300-vw11c2wt	166	26	,	,	,
cord-016300-vw11c2wt	166	27	in	in	IN
cord-016300-vw11c2wt	166	28	conjunction	conjunction	NN
cord-016300-vw11c2wt	166	29	with	with	IN
cord-016300-vw11c2wt	166	30	augmented	augment	VBN
cord-016300-vw11c2wt	166	31	circulating	circulate	VBG
cord-016300-vw11c2wt	166	32	neutrophils	neutrophil	NNS
cord-016300-vw11c2wt	166	33	,	,	,
cord-016300-vw11c2wt	166	34	suggest	suggest	VBP
cord-016300-vw11c2wt	166	35	the	the	DT
cord-016300-vw11c2wt	166	36	involvement	involvement	NN
cord-016300-vw11c2wt	166	37	of	of	IN
cord-016300-vw11c2wt	166	38	neutrophil	neutrophil	NN
cord-016300-vw11c2wt	166	39	-	-	HYPH
cord-016300-vw11c2wt	166	40	derived	derive	VBN
cord-016300-vw11c2wt	166	41	cytokine	cytokine	NN
cord-016300-vw11c2wt	166	42	pattern	pattern	NN
cord-016300-vw11c2wt	166	43	(	(	-LRB-
cord-016300-vw11c2wt	166	44	Silvestri	Silvestri	NNP
cord-016300-vw11c2wt	166	45	et	et	NNP
cord-016300-vw11c2wt	166	46	al	al	NNP
cord-016300-vw11c2wt	166	47	.	.	.
cord-016300-vw11c2wt	166	48	2006	2006	CD
cord-016300-vw11c2wt	166	49	)	)	-RRB-
cord-016300-vw11c2wt	166	50	.	.	.
cord-016300-vw11c2wt	167	1	Furthermore	furthermore	RB
cord-016300-vw11c2wt	167	2	,	,	,
cord-016300-vw11c2wt	167	3	in	in	IN
cord-016300-vw11c2wt	167	4	patients	patient	NNS
cord-016300-vw11c2wt	167	5	with	with	IN
cord-016300-vw11c2wt	167	6	severe	severe	JJ
cord-016300-vw11c2wt	167	7	asthma	asthma	NN
cord-016300-vw11c2wt	167	8	,	,	,
cord-016300-vw11c2wt	167	9	TNF	TNF	NNP
cord-016300-vw11c2wt	167	10	-	-	HYPH
cord-016300-vw11c2wt	167	11	α	α	NNP
cord-016300-vw11c2wt	167	12	levels	level	NNS
cord-016300-vw11c2wt	167	13	were	be	VBD
cord-016300-vw11c2wt	167	14	positively	positively	RB
cord-016300-vw11c2wt	167	15	correlated	correlate	VBN
cord-016300-vw11c2wt	167	16	with	with	IN
cord-016300-vw11c2wt	167	17	both	both	CC
cord-016300-vw11c2wt	167	18	exhaled	exhale	VBN
cord-016300-vw11c2wt	167	19	nitric	nitric	JJ
cord-016300-vw11c2wt	167	20	oxide	oxide	NN
cord-016300-vw11c2wt	167	21	and	and	CC
cord-016300-vw11c2wt	167	22	circulating	circulate	VBG
cord-016300-vw11c2wt	167	23	neutrophil	neutrophil	NN
cord-016300-vw11c2wt	167	24	counts	count	NNS
cord-016300-vw11c2wt	167	25	.	.	.
cord-016300-vw11c2wt	168	1	Cytokine	cytokine	NN
cord-016300-vw11c2wt	168	2	levels	level	NNS
cord-016300-vw11c2wt	168	3	were	be	VBD
cord-016300-vw11c2wt	168	4	elevated	elevate	VBN
cord-016300-vw11c2wt	168	5	even	even	RB
cord-016300-vw11c2wt	168	6	though	though	IN
cord-016300-vw11c2wt	168	7	the	the	DT
cord-016300-vw11c2wt	168	8	patients	patient	NNS
cord-016300-vw11c2wt	168	9	were	be	VBD
cord-016300-vw11c2wt	168	10	on	on	IN
cord-016300-vw11c2wt	168	11	high	high	JJ
cord-016300-vw11c2wt	168	12	-	-	HYPH
cord-016300-vw11c2wt	168	13	dose	dose	NN
cord-016300-vw11c2wt	168	14	inhaled	inhale	VBN
cord-016300-vw11c2wt	168	15	steroids	steroid	NNS
cord-016300-vw11c2wt	168	16	.	.	.
cord-016300-vw11c2wt	169	1	This	this	DT
cord-016300-vw11c2wt	169	2	finding	finding	NN
cord-016300-vw11c2wt	169	3	might	may	MD
cord-016300-vw11c2wt	169	4	reflect	reflect	VB
cord-016300-vw11c2wt	169	5	the	the	DT
cord-016300-vw11c2wt	169	6	inability	inability	NN
cord-016300-vw11c2wt	169	7	of	of	IN
cord-016300-vw11c2wt	169	8	these	these	DT
cord-016300-vw11c2wt	169	9	drugs	drug	NNS
cord-016300-vw11c2wt	169	10	to	to	TO
cord-016300-vw11c2wt	169	11	significantly	significantly	RB
cord-016300-vw11c2wt	169	12	suppress	suppress	VB
cord-016300-vw11c2wt	169	13	production	production	NN
cord-016300-vw11c2wt	169	14	of	of	IN
cord-016300-vw11c2wt	169	15	this	this	DT
cord-016300-vw11c2wt	169	16	cytokine	cytokine	NN
cord-016300-vw11c2wt	169	17	by	by	IN
cord-016300-vw11c2wt	169	18	airway	airway	JJ
cord-016300-vw11c2wt	169	19	cellular	cellular	JJ
cord-016300-vw11c2wt	169	20	sources	source	NNS
cord-016300-vw11c2wt	169	21	including	include	VBG
cord-016300-vw11c2wt	169	22	epithelial	epithelial	JJ
cord-016300-vw11c2wt	169	23	cells	cell	NNS
cord-016300-vw11c2wt	169	24	and	and	CC
cord-016300-vw11c2wt	169	25	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	169	26	cells	cell	NNS
cord-016300-vw11c2wt	169	27	.	.	.
cord-016300-vw11c2wt	170	1	In	in	IN
cord-016300-vw11c2wt	170	2	patients	patient	NNS
cord-016300-vw11c2wt	170	3	with	with	IN
cord-016300-vw11c2wt	170	4	severe	severe	JJ
cord-016300-vw11c2wt	170	5	asthma	asthma	NN
cord-016300-vw11c2wt	170	6	there	there	EX
cord-016300-vw11c2wt	170	7	may	may	MD
cord-016300-vw11c2wt	170	8	be	be	VB
cord-016300-vw11c2wt	170	9	an	an	DT
cord-016300-vw11c2wt	170	10	imbalance	imbalance	NN
cord-016300-vw11c2wt	170	11	between	between	IN
cord-016300-vw11c2wt	170	12	IL-8	il-8	NN
cord-016300-vw11c2wt	170	13	production	production	NN
cord-016300-vw11c2wt	170	14	and	and	CC
cord-016300-vw11c2wt	170	15	the	the	DT
cord-016300-vw11c2wt	170	16	blocking	block	VBG
cord-016300-vw11c2wt	170	17	capacity	capacity	NN
cord-016300-vw11c2wt	170	18	of	of	IN
cord-016300-vw11c2wt	170	19	IL-8	il-8	NN
cord-016300-vw11c2wt	170	20	autoantibodies	autoantibody	NNS
cord-016300-vw11c2wt	170	21	.	.	.
cord-016300-vw11c2wt	171	1	The	the	DT
cord-016300-vw11c2wt	171	2	findings	finding	NNS
cord-016300-vw11c2wt	171	3	of	of	IN
cord-016300-vw11c2wt	171	4	this	this	DT
cord-016300-vw11c2wt	171	5	study	study	NN
cord-016300-vw11c2wt	171	6	may	may	MD
cord-016300-vw11c2wt	171	7	be	be	VB
cord-016300-vw11c2wt	171	8	clinically	clinically	RB
cord-016300-vw11c2wt	171	9	relevant	relevant	JJ
cord-016300-vw11c2wt	171	10	and	and	CC
cord-016300-vw11c2wt	171	11	suggest	suggest	VBP
cord-016300-vw11c2wt	171	12	that	that	IN
cord-016300-vw11c2wt	171	13	drugs	drug	NNS
cord-016300-vw11c2wt	171	14	that	that	WDT
cord-016300-vw11c2wt	171	15	block	block	VBP
cord-016300-vw11c2wt	172	1	TNF	TNF	NNP
cord-016300-vw11c2wt	172	2	-	-	HYPH
cord-016300-vw11c2wt	172	3	α	α	NNP
cord-016300-vw11c2wt	172	4	release	release	NN
cord-016300-vw11c2wt	172	5	or	or	CC
cord-016300-vw11c2wt	172	6	activity	activity	NN
cord-016300-vw11c2wt	172	7	might	may	MD
cord-016300-vw11c2wt	172	8	represent	represent	VB
cord-016300-vw11c2wt	172	9	a	a	DT
cord-016300-vw11c2wt	172	10	new	new	JJ
cord-016300-vw11c2wt	172	11	treatment	treatment	NN
cord-016300-vw11c2wt	172	12	option	option	NN
cord-016300-vw11c2wt	172	13	in	in	IN
cord-016300-vw11c2wt	172	14	severe	severe	JJ
cord-016300-vw11c2wt	172	15	asthma	asthma	NN
cord-016300-vw11c2wt	172	16	.	.	.
cord-016300-vw11c2wt	173	1	Airway	Airway	NNP
cord-016300-vw11c2wt	173	2	hyperresponsiveness	hyperresponsiveness	NN
cord-016300-vw11c2wt	173	3	is	be	VBZ
cord-016300-vw11c2wt	173	4	the	the	DT
cord-016300-vw11c2wt	173	5	main	main	JJ
cord-016300-vw11c2wt	173	6	feature	feature	NN
cord-016300-vw11c2wt	173	7	of	of	IN
cord-016300-vw11c2wt	173	8	asthma	asthma	NN
cord-016300-vw11c2wt	173	9	and	and	CC
cord-016300-vw11c2wt	173	10	is	be	VBZ
cord-016300-vw11c2wt	173	11	defined	define	VBN
cord-016300-vw11c2wt	173	12	as	as	IN
cord-016300-vw11c2wt	173	13	an	an	DT
cord-016300-vw11c2wt	173	14	increase	increase	NN
cord-016300-vw11c2wt	173	15	in	in	IN
cord-016300-vw11c2wt	173	16	the	the	DT
cord-016300-vw11c2wt	173	17	ease	ease	NN
cord-016300-vw11c2wt	173	18	and	and	CC
cord-016300-vw11c2wt	173	19	degree	degree	NN
cord-016300-vw11c2wt	173	20	of	of	IN
cord-016300-vw11c2wt	173	21	airway	airway	NN
cord-016300-vw11c2wt	173	22	narrowing	narrowing	NN
cord-016300-vw11c2wt	173	23	in	in	IN
cord-016300-vw11c2wt	173	24	response	response	NN
cord-016300-vw11c2wt	173	25	to	to	IN
cord-016300-vw11c2wt	173	26	brochoconstrictor	brochoconstrictor	NN
cord-016300-vw11c2wt	173	27	stimuli	stimulus	NNS
cord-016300-vw11c2wt	173	28	.	.	.
cord-016300-vw11c2wt	174	1	Inflammation	inflammation	NN
cord-016300-vw11c2wt	174	2	plays	play	VBZ
cord-016300-vw11c2wt	174	3	a	a	DT
cord-016300-vw11c2wt	174	4	central	central	JJ
cord-016300-vw11c2wt	174	5	role	role	NN
cord-016300-vw11c2wt	174	6	in	in	IN
cord-016300-vw11c2wt	174	7	the	the	DT
cord-016300-vw11c2wt	174	8	pathogenesis	pathogenesis	NN
cord-016300-vw11c2wt	174	9	of	of	IN
cord-016300-vw11c2wt	174	10	asthma	asthma	NN
cord-016300-vw11c2wt	174	11	and	and	CC
cord-016300-vw11c2wt	174	12	much	much	JJ
cord-016300-vw11c2wt	174	13	of	of	IN
cord-016300-vw11c2wt	174	14	it	-PRON-	PRP
cord-016300-vw11c2wt	174	15	can	can	MD
cord-016300-vw11c2wt	174	16	be	be	VB
cord-016300-vw11c2wt	174	17	attributed	attribute	VBN
cord-016300-vw11c2wt	174	18	to	to	IN
cord-016300-vw11c2wt	174	19	helper	helper	NN
cord-016300-vw11c2wt	174	20	T	T	NNP
cord-016300-vw11c2wt	174	21	cell	cell	NN
cord-016300-vw11c2wt	174	22	type	type	NN
cord-016300-vw11c2wt	174	23	2	2	CD
cord-016300-vw11c2wt	174	24	cytokine	cytokine	NN
cord-016300-vw11c2wt	174	25	activation	activation	NN
cord-016300-vw11c2wt	174	26	,	,	,
cord-016300-vw11c2wt	174	27	the	the	DT
cord-016300-vw11c2wt	174	28	degree	degree	NN
cord-016300-vw11c2wt	174	29	of	of	IN
cord-016300-vw11c2wt	174	30	which	which	WDT
cord-016300-vw11c2wt	174	31	strongly	strongly	RB
cord-016300-vw11c2wt	174	32	correlates	correlate	VBZ
cord-016300-vw11c2wt	174	33	to	to	IN
cord-016300-vw11c2wt	174	34	disease	disease	NN
cord-016300-vw11c2wt	174	35	severity	severity	NN
cord-016300-vw11c2wt	174	36	.	.	.
cord-016300-vw11c2wt	175	1	One	one	CD
cord-016300-vw11c2wt	175	2	of	of	IN
cord-016300-vw11c2wt	175	3	the	the	DT
cord-016300-vw11c2wt	175	4	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	175	5	mediators	mediator	NNS
cord-016300-vw11c2wt	175	6	in	in	IN
cord-016300-vw11c2wt	175	7	asthma	asthma	NN
cord-016300-vw11c2wt	175	8	is	be	VBZ
cord-016300-vw11c2wt	175	9	nitric	nitric	JJ
cord-016300-vw11c2wt	175	10	oxide	oxide	NN
cord-016300-vw11c2wt	175	11	(	(	-LRB-
cord-016300-vw11c2wt	175	12	NO	no	RB
cord-016300-vw11c2wt	175	13	)	)	-RRB-
cord-016300-vw11c2wt	175	14	.	.	.
cord-016300-vw11c2wt	176	1	The	the	DT
cord-016300-vw11c2wt	176	2	exhaled	exhaled	JJ
cord-016300-vw11c2wt	176	3	NO	no	DT
cord-016300-vw11c2wt	176	4	level	level	NN
cord-016300-vw11c2wt	176	5	is	be	VBZ
cord-016300-vw11c2wt	176	6	elevated	elevate	VBN
cord-016300-vw11c2wt	176	7	in	in	IN
cord-016300-vw11c2wt	176	8	asthma	asthma	NN
cord-016300-vw11c2wt	176	9	,	,	,
cord-016300-vw11c2wt	176	10	particularly	particularly	RB
cord-016300-vw11c2wt	176	11	allergic	allergic	JJ
cord-016300-vw11c2wt	176	12	asthma	asthma	NN
cord-016300-vw11c2wt	176	13	during	during	IN
cord-016300-vw11c2wt	176	14	the	the	DT
cord-016300-vw11c2wt	176	15	pollen	pollen	NN
cord-016300-vw11c2wt	176	16	season	season	NN
cord-016300-vw11c2wt	176	17	,	,	,
cord-016300-vw11c2wt	176	18	and	and	CC
cord-016300-vw11c2wt	176	19	can	can	MD
cord-016300-vw11c2wt	176	20	predict	predict	VB
cord-016300-vw11c2wt	176	21	asthma	asthma	NN
cord-016300-vw11c2wt	176	22	exacerbation	exacerbation	NN
cord-016300-vw11c2wt	176	23	.	.	.
cord-016300-vw11c2wt	177	1	It	-PRON-	PRP
cord-016300-vw11c2wt	177	2	may	may	MD
cord-016300-vw11c2wt	177	3	be	be	VB
cord-016300-vw11c2wt	177	4	clinically	clinically	RB
cord-016300-vw11c2wt	177	5	more	more	RBR
cord-016300-vw11c2wt	177	6	useful	useful	JJ
cord-016300-vw11c2wt	177	7	to	to	TO
cord-016300-vw11c2wt	177	8	compare	compare	VB
cord-016300-vw11c2wt	177	9	exhaled	exhale	VBN
cord-016300-vw11c2wt	177	10	NO	no	DT
cord-016300-vw11c2wt	177	11	values	value	NNS
cord-016300-vw11c2wt	177	12	with	with	IN
cord-016300-vw11c2wt	177	13	a	a	DT
cord-016300-vw11c2wt	177	14	subject	subject	NN
cord-016300-vw11c2wt	177	15	's	's	POS
cord-016300-vw11c2wt	177	16	previous	previous	JJ
cord-016300-vw11c2wt	177	17	values	value	NNS
cord-016300-vw11c2wt	177	18	than	than	IN
cord-016300-vw11c2wt	177	19	to	to	TO
cord-016300-vw11c2wt	177	20	compare	compare	VB
cord-016300-vw11c2wt	177	21	them	-PRON-	PRP
cord-016300-vw11c2wt	177	22	with	with	IN
cord-016300-vw11c2wt	177	23	a	a	DT
cord-016300-vw11c2wt	177	24	population	population	NN
cord-016300-vw11c2wt	177	25	based	base	VBN
cord-016300-vw11c2wt	177	26	normal	normal	JJ
cord-016300-vw11c2wt	177	27	range	range	NN
cord-016300-vw11c2wt	177	28	.	.	.
cord-016300-vw11c2wt	178	1	Cough	cough	NN
cord-016300-vw11c2wt	178	2	variant	variant	JJ
cord-016300-vw11c2wt	178	3	asthma	asthma	NN
cord-016300-vw11c2wt	178	4	(	(	-LRB-
cord-016300-vw11c2wt	178	5	CVA	CVA	NNP
cord-016300-vw11c2wt	178	6	)	)	-RRB-
cord-016300-vw11c2wt	178	7	and	and	CC
cord-016300-vw11c2wt	178	8	atopic	atopic	NN
cord-016300-vw11c2wt	178	9	cough	cough	NN
cord-016300-vw11c2wt	178	10	both	both	DT
cord-016300-vw11c2wt	178	11	present	present	JJ
cord-016300-vw11c2wt	178	12	with	with	IN
cord-016300-vw11c2wt	178	13	bronchodilator	bronchodilator	NN
cord-016300-vw11c2wt	178	14	-	-	HYPH
cord-016300-vw11c2wt	178	15	resistant	resistant	JJ
cord-016300-vw11c2wt	178	16	non	non	JJ
cord-016300-vw11c2wt	178	17	-	-	JJ
cord-016300-vw11c2wt	178	18	productive	productive	JJ
cord-016300-vw11c2wt	178	19	cough	cough	NN
cord-016300-vw11c2wt	179	1	but	but	CC
cord-016300-vw11c2wt	179	2	may	may	MD
cord-016300-vw11c2wt	179	3	be	be	VB
cord-016300-vw11c2wt	179	4	differentiated	differentiate	VBN
cord-016300-vw11c2wt	179	5	from	from	IN
cord-016300-vw11c2wt	179	6	and	and	CC
cord-016300-vw11c2wt	179	7	other	other	JJ
cord-016300-vw11c2wt	179	8	causes	cause	NNS
cord-016300-vw11c2wt	179	9	of	of	IN
cord-016300-vw11c2wt	179	10	chronic	chronic	JJ
cord-016300-vw11c2wt	179	11	non	non	JJ
cord-016300-vw11c2wt	179	12	-	-	JJ
cord-016300-vw11c2wt	179	13	productive	productive	JJ
cord-016300-vw11c2wt	179	14	cough	cough	NN
cord-016300-vw11c2wt	179	15	by	by	IN
cord-016300-vw11c2wt	179	16	measuring	measure	VBG
cord-016300-vw11c2wt	179	17	exhaled	exhale	VBN
cord-016300-vw11c2wt	180	1	NO	no	UH
cord-016300-vw11c2wt	180	2	.	.	.
cord-016300-vw11c2wt	181	1	Exhaled	exhale	VBN
cord-016300-vw11c2wt	181	2	NO	no	DT
cord-016300-vw11c2wt	181	3	levels	level	NNS
cord-016300-vw11c2wt	181	4	in	in	IN
cord-016300-vw11c2wt	181	5	patients	patient	NNS
cord-016300-vw11c2wt	181	6	with	with	IN
cord-016300-vw11c2wt	181	7	atopic	atopic	JJ
cord-016300-vw11c2wt	181	8	cough	cough	NN
cord-016300-vw11c2wt	181	9	are	be	VBP
cord-016300-vw11c2wt	181	10	significantly	significantly	RB
cord-016300-vw11c2wt	181	11	lower	low	JJR
cord-016300-vw11c2wt	181	12	than	than	IN
cord-016300-vw11c2wt	181	13	those	those	DT
cord-016300-vw11c2wt	181	14	in	in	IN
cord-016300-vw11c2wt	181	15	patients	patient	NNS
cord-016300-vw11c2wt	181	16	with	with	IN
cord-016300-vw11c2wt	181	17	CVA	CVA	NNP
cord-016300-vw11c2wt	181	18	and	and	CC
cord-016300-vw11c2wt	181	19	bronchial	bronchial	JJ
cord-016300-vw11c2wt	181	20	asthma	asthma	NN
cord-016300-vw11c2wt	182	1	(	(	-LRB-
cord-016300-vw11c2wt	182	2	Fujimura	Fujimura	NNP
cord-016300-vw11c2wt	182	3	et	et	FW
cord-016300-vw11c2wt	182	4	al	al	NNP
cord-016300-vw11c2wt	182	5	.	.	NNP
cord-016300-vw11c2wt	182	6	2008	2008	CD
cord-016300-vw11c2wt	182	7	)	)	-RRB-
cord-016300-vw11c2wt	182	8	.	.	.
cord-016300-vw11c2wt	183	1	There	there	EX
cord-016300-vw11c2wt	183	2	are	be	VBP
cord-016300-vw11c2wt	183	3	no	no	DT
cord-016300-vw11c2wt	183	4	significant	significant	JJ
cord-016300-vw11c2wt	183	5	difference	difference	NN
cord-016300-vw11c2wt	183	6	in	in	IN
cord-016300-vw11c2wt	183	7	the	the	DT
cord-016300-vw11c2wt	183	8	exhaled	exhale	VBN
cord-016300-vw11c2wt	183	9	NO	no	DT
cord-016300-vw11c2wt	183	10	levels	level	NNS
cord-016300-vw11c2wt	183	11	between	between	IN
cord-016300-vw11c2wt	183	12	patients	patient	NNS
cord-016300-vw11c2wt	183	13	with	with	IN
cord-016300-vw11c2wt	183	14	CVA	CVA	NNP
cord-016300-vw11c2wt	183	15	and	and	CC
cord-016300-vw11c2wt	183	16	bronchial	bronchial	JJ
cord-016300-vw11c2wt	183	17	asthma	asthma	NN
cord-016300-vw11c2wt	183	18	.	.	.
cord-016300-vw11c2wt	184	1	A	a	DT
cord-016300-vw11c2wt	184	2	UK	UK	NNP
cord-016300-vw11c2wt	184	3	study	study	NN
cord-016300-vw11c2wt	184	4	findings	finding	NNS
cord-016300-vw11c2wt	184	5	show	show	VBP
cord-016300-vw11c2wt	184	6	that	that	IN
cord-016300-vw11c2wt	184	7	it	-PRON-	PRP
cord-016300-vw11c2wt	184	8	is	be	VBZ
cord-016300-vw11c2wt	184	9	feasible	feasible	JJ
cord-016300-vw11c2wt	184	10	to	to	TO
cord-016300-vw11c2wt	184	11	measure	measure	VB
cord-016300-vw11c2wt	184	12	bronchial	bronchial	JJ
cord-016300-vw11c2wt	184	13	flux	flux	NN
cord-016300-vw11c2wt	184	14	NO	no	DT
cord-016300-vw11c2wt	184	15	concentration	concentration	NN
cord-016300-vw11c2wt	184	16	(	(	-LRB-
cord-016300-vw11c2wt	184	17	J	J	NNP
cord-016300-vw11c2wt	184	18	NO	NO	NNP
cord-016300-vw11c2wt	184	19	)	)	-RRB-
cord-016300-vw11c2wt	184	20	and	and	CC
cord-016300-vw11c2wt	184	21	alveolar	alveolar	JJ
cord-016300-vw11c2wt	184	22	NO	no	DT
cord-016300-vw11c2wt	184	23	concentration	concentration	NN
cord-016300-vw11c2wt	184	24	(	(	-LRB-
cord-016300-vw11c2wt	184	25	C	C	NNP
cord-016300-vw11c2wt	184	26	alv	alv	NNP
cord-016300-vw11c2wt	184	27	)	)	-RRB-
cord-016300-vw11c2wt	184	28	in	in	IN
cord-016300-vw11c2wt	184	29	70	70	CD
cord-016300-vw11c2wt	184	30	%	%	NN
cord-016300-vw11c2wt	184	31	of	of	IN
cord-016300-vw11c2wt	184	32	children	child	NNS
cord-016300-vw11c2wt	184	33	,	,	,
cord-016300-vw11c2wt	184	34	with	with	IN
cord-016300-vw11c2wt	184	35	C	C	NNP
cord-016300-vw11c2wt	184	36	alv	alv	NNP
cord-016300-vw11c2wt	184	37	levels	level	NNS
cord-016300-vw11c2wt	184	38	potentially	potentially	RB
cord-016300-vw11c2wt	184	39	reflecting	reflect	VBG
cord-016300-vw11c2wt	184	40	alveolar	alveolar	JJ
cord-016300-vw11c2wt	184	41	inflammation	inflammation	NN
cord-016300-vw11c2wt	184	42	in	in	IN
cord-016300-vw11c2wt	184	43	asthma	asthma	NN
cord-016300-vw11c2wt	184	44	(	(	-LRB-
cord-016300-vw11c2wt	184	45	Paraskakis	Paraskakis	NNP
cord-016300-vw11c2wt	184	46	et	et	NNP
cord-016300-vw11c2wt	184	47	al	al	NNP
cord-016300-vw11c2wt	184	48	.	.	.
cord-016300-vw11c2wt	184	49	2006	2006	CD
cord-016300-vw11c2wt	184	50	)	)	-RRB-
cord-016300-vw11c2wt	184	51	.	.	.
cord-016300-vw11c2wt	185	1	C	C	NNP
cord-016300-vw11c2wt	185	2	alv	alv	NNP
cord-016300-vw11c2wt	185	3	and	and	CC
cord-016300-vw11c2wt	185	4	J	J	NNP
cord-016300-vw11c2wt	185	5	NO	NO	NNP
cord-016300-vw11c2wt	185	6	were	be	VBD
cord-016300-vw11c2wt	185	7	measured	measure	VBN
cord-016300-vw11c2wt	185	8	from	from	IN
cord-016300-vw11c2wt	185	9	the	the	DT
cord-016300-vw11c2wt	185	10	fractional	fractional	JJ
cord-016300-vw11c2wt	185	11	exhaled	exhale	VBN
cord-016300-vw11c2wt	186	1	NO	no	RB
cord-016300-vw11c2wt	187	1	(	(	-LRB-
cord-016300-vw11c2wt	187	2	FeNO	FeNO	NNP
cord-016300-vw11c2wt	187	3	50	50	CD
cord-016300-vw11c2wt	187	4	)	)	-RRB-
cord-016300-vw11c2wt	187	5	at	at	IN
cord-016300-vw11c2wt	187	6	multiple	multiple	JJ
cord-016300-vw11c2wt	187	7	exhalation	exhalation	NN
cord-016300-vw11c2wt	187	8	flow	flow	NN
cord-016300-vw11c2wt	187	9	rates	rate	NNS
cord-016300-vw11c2wt	187	10	in	in	IN
cord-016300-vw11c2wt	187	11	asthmatic	asthmatic	JJ
cord-016300-vw11c2wt	187	12	children	child	NNS
cord-016300-vw11c2wt	187	13	.	.	.
cord-016300-vw11c2wt	188	1	Although	although	IN
cord-016300-vw11c2wt	188	2	FeNO	FeNO	NNP
cord-016300-vw11c2wt	188	3	50	50	CD
cord-016300-vw11c2wt	188	4	and	and	CC
cord-016300-vw11c2wt	188	5	JNO	JNO	NNP
cord-016300-vw11c2wt	188	6	give	give	VBP
cord-016300-vw11c2wt	188	7	essentially	essentially	RB
cord-016300-vw11c2wt	188	8	the	the	DT
cord-016300-vw11c2wt	188	9	same	same	JJ
cord-016300-vw11c2wt	188	10	information	information	NN
cord-016300-vw11c2wt	188	11	,	,	,
cord-016300-vw11c2wt	188	12	C	C	NNP
cord-016300-vw11c2wt	188	13	alv	alv	NNP
cord-016300-vw11c2wt	188	14	is	be	VBZ
cord-016300-vw11c2wt	188	15	higher	high	JJR
cord-016300-vw11c2wt	188	16	in	in	IN
cord-016300-vw11c2wt	188	17	asthmatic	asthmatic	JJ
cord-016300-vw11c2wt	188	18	children	child	NNS
cord-016300-vw11c2wt	188	19	than	than	IN
cord-016300-vw11c2wt	188	20	in	in	IN
cord-016300-vw11c2wt	188	21	normal	normal	JJ
cord-016300-vw11c2wt	188	22	children	child	NNS
cord-016300-vw11c2wt	188	23	.	.	.
cord-016300-vw11c2wt	189	1	This	this	DT
cord-016300-vw11c2wt	189	2	study	study	NN
cord-016300-vw11c2wt	189	3	also	also	RB
cord-016300-vw11c2wt	189	4	highlights	highlight	VBZ
cord-016300-vw11c2wt	189	5	the	the	DT
cord-016300-vw11c2wt	189	6	relationship	relationship	NN
cord-016300-vw11c2wt	189	7	between	between	IN
cord-016300-vw11c2wt	189	8	poor	poor	JJ
cord-016300-vw11c2wt	189	9	control	control	NN
cord-016300-vw11c2wt	189	10	of	of	IN
cord-016300-vw11c2wt	189	11	asthma	asthma	NN
cord-016300-vw11c2wt	189	12	and	and	CC
cord-016300-vw11c2wt	189	13	C	C	NNP
cord-016300-vw11c2wt	189	14	alv	alv	NNP
cord-016300-vw11c2wt	189	15	(	(	-LRB-
cord-016300-vw11c2wt	189	16	a	a	DT
cord-016300-vw11c2wt	189	17	biomarker	biomarker	NN
cord-016300-vw11c2wt	189	18	of	of	IN
cord-016300-vw11c2wt	189	19	alveolar	alveolar	JJ
cord-016300-vw11c2wt	189	20	inflammation	inflammation	NN
cord-016300-vw11c2wt	189	21	)	)	-RRB-
cord-016300-vw11c2wt	189	22	but	but	CC
cord-016300-vw11c2wt	189	23	further	further	JJ
cord-016300-vw11c2wt	189	24	work	work	NN
cord-016300-vw11c2wt	189	25	is	be	VBZ
cord-016300-vw11c2wt	189	26	needed	need	VBN
cord-016300-vw11c2wt	189	27	to	to	TO
cord-016300-vw11c2wt	189	28	confirm	confirm	VB
cord-016300-vw11c2wt	189	29	the	the	DT
cord-016300-vw11c2wt	189	30	relevance	relevance	NN
cord-016300-vw11c2wt	189	31	of	of	IN
cord-016300-vw11c2wt	189	32	this	this	DT
cord-016300-vw11c2wt	189	33	.	.	.
cord-016300-vw11c2wt	190	1	A	a	DT
cord-016300-vw11c2wt	190	2	novel	novel	NN
cord-016300-vw11c2wt	190	3	nanosensor	nanosensor	NN
cord-016300-vw11c2wt	190	4	can	can	MD
cord-016300-vw11c2wt	190	5	detect	detect	VB
cord-016300-vw11c2wt	190	6	a	a	DT
cord-016300-vw11c2wt	190	7	possible	possible	JJ
cord-016300-vw11c2wt	190	8	asthma	asthma	NN
cord-016300-vw11c2wt	190	9	attack	attack	NN
cord-016300-vw11c2wt	190	10	before	before	IN
cord-016300-vw11c2wt	190	11	it	-PRON-	PRP
cord-016300-vw11c2wt	190	12	begins	begin	VBZ
cord-016300-vw11c2wt	190	13	.	.	.
cord-016300-vw11c2wt	191	1	The	the	DT
cord-016300-vw11c2wt	191	2	minute	minute	NN
cord-016300-vw11c2wt	191	3	sensor	sensor	NN
cord-016300-vw11c2wt	191	4	can	can	MD
cord-016300-vw11c2wt	191	5	be	be	VB
cord-016300-vw11c2wt	191	6	fitted	fit	VBN
cord-016300-vw11c2wt	191	7	into	into	IN
cord-016300-vw11c2wt	191	8	a	a	DT
cord-016300-vw11c2wt	191	9	hand	hand	NN
cord-016300-vw11c2wt	191	10	-	-	HYPH
cord-016300-vw11c2wt	191	11	held	hold	VBN
cord-016300-vw11c2wt	191	12	device	device	NN
cord-016300-vw11c2wt	191	13	,	,	,
cord-016300-vw11c2wt	191	14	and	and	CC
cord-016300-vw11c2wt	191	15	when	when	WRB
cord-016300-vw11c2wt	191	16	a	a	DT
cord-016300-vw11c2wt	191	17	person	person	NN
cord-016300-vw11c2wt	191	18	blows	blow	VBZ
cord-016300-vw11c2wt	191	19	into	into	IN
cord-016300-vw11c2wt	191	20	the	the	DT
cord-016300-vw11c2wt	191	21	device	device	NN
cord-016300-vw11c2wt	191	22	,	,	,
cord-016300-vw11c2wt	191	23	it	-PRON-	PRP
cord-016300-vw11c2wt	191	24	measures	measure	VBZ
cord-016300-vw11c2wt	191	25	the	the	DT
cord-016300-vw11c2wt	191	26	NO	no	DT
cord-016300-vw11c2wt	191	27	content	content	NN
cord-016300-vw11c2wt	191	28	of	of	IN
cord-016300-vw11c2wt	191	29	their	-PRON-	PRP$
cord-016300-vw11c2wt	191	30	breath	breath	NN
cord-016300-vw11c2wt	191	31	.	.	.
cord-016300-vw11c2wt	192	1	Use	use	NN
cord-016300-vw11c2wt	192	2	of	of	IN
cord-016300-vw11c2wt	192	3	this	this	DT
cord-016300-vw11c2wt	192	4	device	device	NN
cord-016300-vw11c2wt	192	5	would	would	MD
cord-016300-vw11c2wt	192	6	provide	provide	VB
cord-016300-vw11c2wt	192	7	asthma	asthma	NN
cord-016300-vw11c2wt	192	8	sufferers	sufferer	NNS
cord-016300-vw11c2wt	192	9	with	with	IN
cord-016300-vw11c2wt	192	10	a	a	DT
cord-016300-vw11c2wt	192	11	simple	simple	JJ
cord-016300-vw11c2wt	192	12	and	and	CC
cord-016300-vw11c2wt	192	13	cost	cost	VBD
cord-016300-vw11c2wt	192	14	effective	effective	JJ
cord-016300-vw11c2wt	192	15	way	way	NN
cord-016300-vw11c2wt	192	16	to	to	TO
cord-016300-vw11c2wt	192	17	monitor	monitor	VB
cord-016300-vw11c2wt	192	18	their	-PRON-	PRP$
cord-016300-vw11c2wt	192	19	asthma	asthma	NN
cord-016300-vw11c2wt	192	20	inflammation	inflammation	NN
cord-016300-vw11c2wt	192	21	.	.	.
cord-016300-vw11c2wt	193	1	An	an	DT
cord-016300-vw11c2wt	193	2	explanation	explanation	NN
cord-016300-vw11c2wt	193	3	for	for	IN
cord-016300-vw11c2wt	193	4	increased	increase	VBN
cord-016300-vw11c2wt	193	5	levels	level	NNS
cord-016300-vw11c2wt	193	6	of	of	IN
cord-016300-vw11c2wt	193	7	exhaled	exhale	VBN
cord-016300-vw11c2wt	193	8	NO	no	NN
cord-016300-vw11c2wt	193	9	is	be	VBZ
cord-016300-vw11c2wt	193	10	nonenzymatic	nonenzymatic	JJ
cord-016300-vw11c2wt	193	11	generation	generation	NN
cord-016300-vw11c2wt	193	12	of	of	IN
cord-016300-vw11c2wt	193	13	NO	no	DT
cord-016300-vw11c2wt	193	14	from	from	IN
cord-016300-vw11c2wt	193	15	nitrite	nitrite	NN
cord-016300-vw11c2wt	193	16	due	due	IN
cord-016300-vw11c2wt	193	17	to	to	IN
cord-016300-vw11c2wt	193	18	airway	airway	JJ
cord-016300-vw11c2wt	193	19	acidification	acidification	NN
cord-016300-vw11c2wt	193	20	in	in	IN
cord-016300-vw11c2wt	193	21	asthmatics	asthmatic	NNS
cord-016300-vw11c2wt	193	22	.	.	.
cord-016300-vw11c2wt	194	1	Reduced	reduce	VBN
cord-016300-vw11c2wt	194	2	arginine	arginine	NN
cord-016300-vw11c2wt	194	3	availability	availability	NN
cord-016300-vw11c2wt	194	4	may	may	MD
cord-016300-vw11c2wt	194	5	also	also	RB
cord-016300-vw11c2wt	194	6	contribute	contribute	VB
cord-016300-vw11c2wt	194	7	to	to	IN
cord-016300-vw11c2wt	194	8	lung	lung	NN
cord-016300-vw11c2wt	194	9	injury	injury	NN
cord-016300-vw11c2wt	194	10	by	by	IN
cord-016300-vw11c2wt	194	11	promoting	promote	VBG
cord-016300-vw11c2wt	194	12	formation	formation	NN
cord-016300-vw11c2wt	194	13	of	of	IN
cord-016300-vw11c2wt	194	14	cytotoxic	cytotoxic	JJ
cord-016300-vw11c2wt	194	15	radicals	radical	NNS
cord-016300-vw11c2wt	194	16	such	such	JJ
cord-016300-vw11c2wt	194	17	as	as	IN
cord-016300-vw11c2wt	194	18	peroxynitrite	peroxynitrite	NNP
cord-016300-vw11c2wt	194	19	.	.	.
cord-016300-vw11c2wt	195	1	As	as	IN
cord-016300-vw11c2wt	195	2	arginine	arginine	NN
cord-016300-vw11c2wt	195	3	levels	level	NNS
cord-016300-vw11c2wt	195	4	decline	decline	VBP
cord-016300-vw11c2wt	195	5	,	,	,
cord-016300-vw11c2wt	195	6	nitric	nitric	JJ
cord-016300-vw11c2wt	195	7	oxide	oxide	NN
cord-016300-vw11c2wt	195	8	synthase	synthase	NN
cord-016300-vw11c2wt	195	9	(	(	-LRB-
cord-016300-vw11c2wt	195	10	NOS	NOS	NNP
cord-016300-vw11c2wt	195	11	)	)	-RRB-
cord-016300-vw11c2wt	195	12	itself	-PRON-	PRP
cord-016300-vw11c2wt	195	13	can	can	MD
cord-016300-vw11c2wt	195	14	begin	begin	VB
cord-016300-vw11c2wt	195	15	to	to	TO
cord-016300-vw11c2wt	195	16	generate	generate	VB
cord-016300-vw11c2wt	195	17	superoxide	superoxide	NN
cord-016300-vw11c2wt	195	18	in	in	IN
cord-016300-vw11c2wt	195	19	lieu	lieu	NN
cord-016300-vw11c2wt	195	20	of	of	IN
cord-016300-vw11c2wt	195	21	NO	no	NN
cord-016300-vw11c2wt	195	22	,	,	,
cord-016300-vw11c2wt	195	23	thereby	thereby	RB
cord-016300-vw11c2wt	195	24	favoring	favor	VBG
cord-016300-vw11c2wt	195	25	NO	no	DT
cord-016300-vw11c2wt	195	26	consumption	consumption	NN
cord-016300-vw11c2wt	195	27	via	via	IN
cord-016300-vw11c2wt	195	28	the	the	DT
cord-016300-vw11c2wt	195	29	generation	generation	NN
cord-016300-vw11c2wt	195	30	of	of	IN
cord-016300-vw11c2wt	195	31	peroxynitrite	peroxynitrite	NN
cord-016300-vw11c2wt	195	32	that	that	WDT
cord-016300-vw11c2wt	195	33	could	could	MD
cord-016300-vw11c2wt	195	34	induce	induce	VB
cord-016300-vw11c2wt	195	35	lung	lung	NN
cord-016300-vw11c2wt	195	36	injury	injury	NN
cord-016300-vw11c2wt	195	37	.	.	.
cord-016300-vw11c2wt	196	1	This	this	DT
cord-016300-vw11c2wt	196	2	reduction	reduction	NN
cord-016300-vw11c2wt	196	3	in	in	IN
cord-016300-vw11c2wt	196	4	bioavailability	bioavailability	NN
cord-016300-vw11c2wt	196	5	of	of	IN
cord-016300-vw11c2wt	196	6	NO	no	DT
cord-016300-vw11c2wt	196	7	via	via	IN
cord-016300-vw11c2wt	196	8	formation	formation	NN
cord-016300-vw11c2wt	196	9	of	of	IN
cord-016300-vw11c2wt	196	10	species	specie	NNS
cord-016300-vw11c2wt	196	11	such	such	JJ
cord-016300-vw11c2wt	196	12	as	as	IN
cord-016300-vw11c2wt	196	13	peroxynitrite	peroxynitrite	NN
cord-016300-vw11c2wt	196	14	could	could	MD
cord-016300-vw11c2wt	196	15	be	be	VB
cord-016300-vw11c2wt	196	16	further	further	RB
cord-016300-vw11c2wt	196	17	amplified	amplify	VBN
cord-016300-vw11c2wt	196	18	by	by	IN
cord-016300-vw11c2wt	196	19	the	the	DT
cord-016300-vw11c2wt	196	20	rapid	rapid	JJ
cord-016300-vw11c2wt	196	21	loss	loss	NN
cord-016300-vw11c2wt	196	22	of	of	IN
cord-016300-vw11c2wt	196	23	SOD	sod	NN
cord-016300-vw11c2wt	196	24	activity	activity	NN
cord-016300-vw11c2wt	196	25	during	during	IN
cord-016300-vw11c2wt	196	26	the	the	DT
cord-016300-vw11c2wt	196	27	asthmatic	asthmatic	JJ
cord-016300-vw11c2wt	196	28	response	response	NN
cord-016300-vw11c2wt	196	29	.	.	.
cord-016300-vw11c2wt	197	1	Plasma	plasma	NN
cord-016300-vw11c2wt	197	2	arginase	arginase	NN
cord-016300-vw11c2wt	197	3	activity	activity	NN
cord-016300-vw11c2wt	197	4	declines	decline	VBZ
cord-016300-vw11c2wt	197	5	significantly	significantly	RB
cord-016300-vw11c2wt	197	6	with	with	IN
cord-016300-vw11c2wt	197	7	treatment	treatment	NN
cord-016300-vw11c2wt	197	8	and	and	CC
cord-016300-vw11c2wt	197	9	improvement	improvement	NN
cord-016300-vw11c2wt	197	10	of	of	IN
cord-016300-vw11c2wt	197	11	symptoms	symptom	NNS
cord-016300-vw11c2wt	197	12	.	.	.
cord-016300-vw11c2wt	198	1	Additional	additional	JJ
cord-016300-vw11c2wt	198	2	studies	study	NNS
cord-016300-vw11c2wt	198	3	are	be	VBP
cord-016300-vw11c2wt	198	4	needed	need	VBN
cord-016300-vw11c2wt	198	5	to	to	TO
cord-016300-vw11c2wt	198	6	determine	determine	VB
cord-016300-vw11c2wt	198	7	whether	whether	IN
cord-016300-vw11c2wt	198	8	measurements	measurement	NNS
cord-016300-vw11c2wt	198	9	of	of	IN
cord-016300-vw11c2wt	198	10	plasma	plasma	NN
cord-016300-vw11c2wt	198	11	arginase	arginase	NN
cord-016300-vw11c2wt	198	12	activity	activity	NN
cord-016300-vw11c2wt	198	13	will	will	MD
cord-016300-vw11c2wt	198	14	provide	provide	VB
cord-016300-vw11c2wt	198	15	a	a	DT
cord-016300-vw11c2wt	198	16	useful	useful	JJ
cord-016300-vw11c2wt	198	17	biomarker	biomarker	NN
cord-016300-vw11c2wt	198	18	for	for	IN
cord-016300-vw11c2wt	198	19	underlying	underlie	VBG
cord-016300-vw11c2wt	198	20	metabolic	metabolic	JJ
cord-016300-vw11c2wt	198	21	disorder	disorder	NN
cord-016300-vw11c2wt	198	22	and	and	CC
cord-016300-vw11c2wt	198	23	efficacy	efficacy	NN
cord-016300-vw11c2wt	198	24	of	of	IN
cord-016300-vw11c2wt	198	25	treatment	treatment	NN
cord-016300-vw11c2wt	198	26	for	for	IN
cord-016300-vw11c2wt	198	27	this	this	DT
cord-016300-vw11c2wt	198	28	disease	disease	NN
cord-016300-vw11c2wt	198	29	.	.	.
cord-016300-vw11c2wt	199	1	The	the	DT
cord-016300-vw11c2wt	199	2	arginase	arginase	NN
cord-016300-vw11c2wt	199	3	activity	activity	NN
cord-016300-vw11c2wt	199	4	present	present	NN
cord-016300-vw11c2wt	199	5	in	in	IN
cord-016300-vw11c2wt	199	6	serum	serum	NN
cord-016300-vw11c2wt	199	7	probably	probably	RB
cord-016300-vw11c2wt	199	8	does	do	VBZ
cord-016300-vw11c2wt	199	9	not	not	RB
cord-016300-vw11c2wt	199	10	accurately	accurately	RB
cord-016300-vw11c2wt	199	11	reflect	reflect	VB
cord-016300-vw11c2wt	199	12	whole	whole	JJ
cord-016300-vw11c2wt	199	13	body	body	NN
cord-016300-vw11c2wt	199	14	arginase	arginase	NN
cord-016300-vw11c2wt	199	15	activity	activity	NN
cord-016300-vw11c2wt	199	16	or	or	CC
cord-016300-vw11c2wt	199	17	that	that	IN
cord-016300-vw11c2wt	199	18	compartmentalized	compartmentalize	VBN
cord-016300-vw11c2wt	199	19	in	in	IN
cord-016300-vw11c2wt	199	20	the	the	DT
cord-016300-vw11c2wt	199	21	lungs	lung	NNS
cord-016300-vw11c2wt	199	22	,	,	,
cord-016300-vw11c2wt	199	23	since	since	IN
cord-016300-vw11c2wt	199	24	the	the	DT
cord-016300-vw11c2wt	199	25	arginases	arginase	NNS
cord-016300-vw11c2wt	199	26	are	be	VBP
cord-016300-vw11c2wt	199	27	intracellular	intracellular	JJ
cord-016300-vw11c2wt	199	28	enzymes	enzyme	NNS
cord-016300-vw11c2wt	199	29	.	.	.
cord-016300-vw11c2wt	200	1	Because	because	IN
cord-016300-vw11c2wt	200	2	arginase	arginase	NNP
cord-016300-vw11c2wt	200	3	is	be	VBZ
cord-016300-vw11c2wt	200	4	induced	induce	VBN
cord-016300-vw11c2wt	200	5	in	in	IN
cord-016300-vw11c2wt	200	6	monocytes	monocyte	NNS
cord-016300-vw11c2wt	200	7	in	in	IN
cord-016300-vw11c2wt	200	8	response	response	NN
cord-016300-vw11c2wt	200	9	to	to	IN
cord-016300-vw11c2wt	200	10	helper	helper	NN
cord-016300-vw11c2wt	200	11	T	T	NNP
cord-016300-vw11c2wt	200	12	cell	cell	NN
cord-016300-vw11c2wt	200	13	type	type	NN
cord-016300-vw11c2wt	200	14	2	2	CD
cord-016300-vw11c2wt	200	15	cytokines	cytokine	NNS
cord-016300-vw11c2wt	200	16	,	,	,
cord-016300-vw11c2wt	200	17	it	-PRON-	PRP
cord-016300-vw11c2wt	200	18	is	be	VBZ
cord-016300-vw11c2wt	200	19	speculated	speculate	VBN
cord-016300-vw11c2wt	200	20	that	that	IN
cord-016300-vw11c2wt	200	21	these	these	DT
cord-016300-vw11c2wt	200	22	cells	cell	NNS
cord-016300-vw11c2wt	200	23	are	be	VBP
cord-016300-vw11c2wt	200	24	one	one	CD
cord-016300-vw11c2wt	200	25	likely	likely	JJ
cord-016300-vw11c2wt	200	26	source	source	NN
cord-016300-vw11c2wt	200	27	of	of	IN
cord-016300-vw11c2wt	200	28	the	the	DT
cord-016300-vw11c2wt	200	29	elevated	elevated	JJ
cord-016300-vw11c2wt	200	30	arginase	arginase	NN
cord-016300-vw11c2wt	200	31	in	in	IN
cord-016300-vw11c2wt	200	32	serum	serum	NN
cord-016300-vw11c2wt	200	33	,	,	,
cord-016300-vw11c2wt	200	34	consistent	consistent	JJ
cord-016300-vw11c2wt	200	35	with	with	IN
cord-016300-vw11c2wt	200	36	the	the	DT
cord-016300-vw11c2wt	200	37	localization	localization	NN
cord-016300-vw11c2wt	200	38	of	of	IN
cord-016300-vw11c2wt	200	39	arginase	arginase	JJ
cord-016300-vw11c2wt	200	40	expression	expression	NN
cord-016300-vw11c2wt	200	41	within	within	IN
cord-016300-vw11c2wt	200	42	macrophages	macrophage	NNS
cord-016300-vw11c2wt	200	43	in	in	IN
cord-016300-vw11c2wt	200	44	the	the	DT
cord-016300-vw11c2wt	200	45	lungs	lung	NNS
cord-016300-vw11c2wt	200	46	.	.	.
cord-016300-vw11c2wt	201	1	Athough	Athough	NNP
cord-016300-vw11c2wt	201	2	exhaled	exhale	VBD
cord-016300-vw11c2wt	201	3	NO	no	DT
cord-016300-vw11c2wt	201	4	is	be	VBZ
cord-016300-vw11c2wt	201	5	a	a	DT
cord-016300-vw11c2wt	201	6	clinically	clinically	RB
cord-016300-vw11c2wt	201	7	useful	useful	JJ
cord-016300-vw11c2wt	201	8	biomarker	biomarker	NN
cord-016300-vw11c2wt	201	9	of	of	IN
cord-016300-vw11c2wt	201	10	eosinophilic	eosinophilic	JJ
cord-016300-vw11c2wt	201	11	airway	airway	NN
cord-016300-vw11c2wt	201	12	inflammation	inflammation	NN
cord-016300-vw11c2wt	201	13	in	in	IN
cord-016300-vw11c2wt	201	14	asthma	asthma	NN
cord-016300-vw11c2wt	201	15	,	,	,
cord-016300-vw11c2wt	201	16	significant	significant	JJ
cord-016300-vw11c2wt	201	17	validation	validation	NN
cord-016300-vw11c2wt	201	18	and	and	CC
cord-016300-vw11c2wt	201	19	investigation	investigation	NN
cord-016300-vw11c2wt	201	20	are	be	VBP
cord-016300-vw11c2wt	201	21	required	require	VBN
cord-016300-vw11c2wt	201	22	before	before	IN
cord-016300-vw11c2wt	201	23	exhaled	exhale	VBN
cord-016300-vw11c2wt	201	24	breath	breath	NN
cord-016300-vw11c2wt	201	25	condensate	condensate	NN
cord-016300-vw11c2wt	201	26	could	could	MD
cord-016300-vw11c2wt	201	27	be	be	VB
cord-016300-vw11c2wt	201	28	utilized	utilize	VBN
cord-016300-vw11c2wt	201	29	for	for	IN
cord-016300-vw11c2wt	201	30	making	make	VBG
cord-016300-vw11c2wt	201	31	decisions	decision	NNS
cord-016300-vw11c2wt	201	32	in	in	IN
cord-016300-vw11c2wt	201	33	clinical	clinical	JJ
cord-016300-vw11c2wt	201	34	practice	practice	NN
cord-016300-vw11c2wt	201	35	(	(	-LRB-
cord-016300-vw11c2wt	201	36	Simpson	Simpson	NNP
cord-016300-vw11c2wt	201	37	and	and	CC
cord-016300-vw11c2wt	201	38	Wark	Wark	NNP
cord-016300-vw11c2wt	201	39	2008	2008	CD
cord-016300-vw11c2wt	201	40	)	)	-RRB-
cord-016300-vw11c2wt	201	41	.	.	.
cord-016300-vw11c2wt	202	1	Endothelins	endothelin	NNS
cord-016300-vw11c2wt	202	2	are	be	VBP
cord-016300-vw11c2wt	202	3	proinflammatory	proinflammatory	JJ
cord-016300-vw11c2wt	202	4	,	,	,
cord-016300-vw11c2wt	202	5	profibrotic	profibrotic	JJ
cord-016300-vw11c2wt	202	6	,	,	,
cord-016300-vw11c2wt	202	7	broncho	broncho	JJ
cord-016300-vw11c2wt	202	8	-	-	HYPH
cord-016300-vw11c2wt	202	9	and	and	CC
cord-016300-vw11c2wt	202	10	vasoconstrictive	vasoconstrictive	JJ
cord-016300-vw11c2wt	202	11	peptides	peptide	NNS
cord-016300-vw11c2wt	202	12	,	,	,
cord-016300-vw11c2wt	202	13	which	which	WDT
cord-016300-vw11c2wt	202	14	play	play	VBP
cord-016300-vw11c2wt	202	15	an	an	DT
cord-016300-vw11c2wt	202	16	important	important	JJ
cord-016300-vw11c2wt	202	17	role	role	NN
cord-016300-vw11c2wt	202	18	in	in	IN
cord-016300-vw11c2wt	202	19	the	the	DT
cord-016300-vw11c2wt	202	20	development	development	NN
cord-016300-vw11c2wt	202	21	of	of	IN
cord-016300-vw11c2wt	202	22	airway	airway	JJ
cord-016300-vw11c2wt	202	23	inflammation	inflammation	NN
cord-016300-vw11c2wt	202	24	and	and	CC
cord-016300-vw11c2wt	202	25	remodeling	remodeling	NN
cord-016300-vw11c2wt	202	26	in	in	IN
cord-016300-vw11c2wt	202	27	asthma	asthma	NN
cord-016300-vw11c2wt	202	28	.	.	.
cord-016300-vw11c2wt	203	1	A	a	DT
cord-016300-vw11c2wt	203	2	study	study	NN
cord-016300-vw11c2wt	203	3	has	have	VBZ
cord-016300-vw11c2wt	203	4	evaluated	evaluate	VBN
cord-016300-vw11c2wt	203	5	the	the	DT
cord-016300-vw11c2wt	203	6	endothelin-1	endothelin-1	NNP
cord-016300-vw11c2wt	203	7	(	(	-LRB-
cord-016300-vw11c2wt	203	8	ET-1	ET-1	NNP
cord-016300-vw11c2wt	203	9	)	)	-RRB-
cord-016300-vw11c2wt	203	10	levels	level	NNS
cord-016300-vw11c2wt	203	11	in	in	IN
cord-016300-vw11c2wt	203	12	exhaled	exhale	VBN
cord-016300-vw11c2wt	203	13	breath	breath	NN
cord-016300-vw11c2wt	203	14	condensate	condensate	NN
cord-016300-vw11c2wt	203	15	(	(	-LRB-
cord-016300-vw11c2wt	203	16	EBC	EBC	NNP
cord-016300-vw11c2wt	203	17	)	)	-RRB-
cord-016300-vw11c2wt	203	18	of	of	IN
cord-016300-vw11c2wt	203	19	asthmatics	asthmatic	NNS
cord-016300-vw11c2wt	203	20	with	with	IN
cord-016300-vw11c2wt	203	21	different	different	JJ
cord-016300-vw11c2wt	203	22	degree	degree	NN
cord-016300-vw11c2wt	203	23	in	in	IN
cord-016300-vw11c2wt	203	24	asthma	asthma	NN
cord-016300-vw11c2wt	203	25	severity	severity	NN
cord-016300-vw11c2wt	203	26	(	(	-LRB-
cord-016300-vw11c2wt	203	27	Zietkowski	Zietkowski	NNP
cord-016300-vw11c2wt	203	28	et	et	NNP
cord-016300-vw11c2wt	203	29	al	al	NNP
cord-016300-vw11c2wt	203	30	.	.	NNP
cord-016300-vw11c2wt	203	31	2008	2008	CD
cord-016300-vw11c2wt	203	32	)	)	-RRB-
cord-016300-vw11c2wt	203	33	.	.	.
cord-016300-vw11c2wt	204	1	ET-1	ET-1	NNP
cord-016300-vw11c2wt	204	2	concentrations	concentration	NNS
cord-016300-vw11c2wt	204	3	in	in	IN
cord-016300-vw11c2wt	204	4	EBC	EBC	NNP
cord-016300-vw11c2wt	204	5	of	of	IN
cord-016300-vw11c2wt	204	6	all	all	DT
cord-016300-vw11c2wt	204	7	asthmatic	asthmatic	JJ
cord-016300-vw11c2wt	204	8	patients	patient	NNS
cord-016300-vw11c2wt	204	9	were	be	VBD
cord-016300-vw11c2wt	204	10	significantly	significantly	RB
cord-016300-vw11c2wt	204	11	higher	high	JJR
cord-016300-vw11c2wt	204	12	than	than	IN
cord-016300-vw11c2wt	204	13	in	in	IN
cord-016300-vw11c2wt	204	14	healthy	healthy	JJ
cord-016300-vw11c2wt	204	15	volunteers	volunteer	NNS
cord-016300-vw11c2wt	204	16	.	.	.
cord-016300-vw11c2wt	205	1	ET-1	ET-1	NNP
cord-016300-vw11c2wt	205	2	levels	level	NNS
cord-016300-vw11c2wt	205	3	were	be	VBD
cord-016300-vw11c2wt	205	4	significantly	significantly	RB
cord-016300-vw11c2wt	205	5	higher	high	JJR
cord-016300-vw11c2wt	205	6	in	in	IN
cord-016300-vw11c2wt	205	7	patients	patient	NNS
cord-016300-vw11c2wt	205	8	with	with	IN
cord-016300-vw11c2wt	205	9	unstable	unstable	JJ
cord-016300-vw11c2wt	205	10	asthma	asthma	NN
cord-016300-vw11c2wt	205	11	than	than	IN
cord-016300-vw11c2wt	205	12	in	in	IN
cord-016300-vw11c2wt	205	13	the	the	DT
cord-016300-vw11c2wt	205	14	two	two	CD
cord-016300-vw11c2wt	205	15	groups	group	NNS
cord-016300-vw11c2wt	205	16	with	with	IN
cord-016300-vw11c2wt	205	17	stable	stable	JJ
cord-016300-vw11c2wt	205	18	disease	disease	NN
cord-016300-vw11c2wt	205	19	.	.	.
cord-016300-vw11c2wt	206	1	Thus	thus	RB
cord-016300-vw11c2wt	206	2	,	,	,
cord-016300-vw11c2wt	206	3	measurements	measurement	NNS
cord-016300-vw11c2wt	206	4	of	of	IN
cord-016300-vw11c2wt	206	5	ET-1	ET-1	NNP
cord-016300-vw11c2wt	206	6	in	in	IN
cord-016300-vw11c2wt	206	7	EBC	EBC	NNP
cord-016300-vw11c2wt	206	8	may	may	MD
cord-016300-vw11c2wt	206	9	provide	provide	VB
cord-016300-vw11c2wt	206	10	another	another	DT
cord-016300-vw11c2wt	206	11	useful	useful	JJ
cord-016300-vw11c2wt	206	12	diagnostic	diagnostic	JJ
cord-016300-vw11c2wt	206	13	tool	tool	NN
cord-016300-vw11c2wt	206	14	for	for	IN
cord-016300-vw11c2wt	206	15	detecting	detect	VBG
cord-016300-vw11c2wt	206	16	and	and	CC
cord-016300-vw11c2wt	206	17	monitoring	monitor	VBG
cord-016300-vw11c2wt	206	18	inflammation	inflammation	NN
cord-016300-vw11c2wt	206	19	in	in	IN
cord-016300-vw11c2wt	206	20	patients	patient	NNS
cord-016300-vw11c2wt	206	21	with	with	IN
cord-016300-vw11c2wt	206	22	asthma	asthma	NN
cord-016300-vw11c2wt	206	23	.	.	.
cord-016300-vw11c2wt	207	1	The	the	DT
cord-016300-vw11c2wt	207	2	release	release	NN
cord-016300-vw11c2wt	207	3	of	of	IN
cord-016300-vw11c2wt	207	4	ET-1	ET-1	NNP
cord-016300-vw11c2wt	207	5	from	from	IN
cord-016300-vw11c2wt	207	6	bronchial	bronchial	JJ
cord-016300-vw11c2wt	207	7	epithelium	epithelium	NN
cord-016300-vw11c2wt	207	8	through	through	IN
cord-016300-vw11c2wt	207	9	the	the	DT
cord-016300-vw11c2wt	207	10	influence	influence	NN
cord-016300-vw11c2wt	207	11	of	of	IN
cord-016300-vw11c2wt	207	12	many	many	JJ
cord-016300-vw11c2wt	207	13	inflammatory	inflammatory	JJ
cord-016300-vw11c2wt	207	14	cells	cell	NNS
cord-016300-vw11c2wt	207	15	essential	essential	JJ
cord-016300-vw11c2wt	207	16	in	in	IN
cord-016300-vw11c2wt	207	17	asthma	asthma	NN
cord-016300-vw11c2wt	207	18	and	and	CC
cord-016300-vw11c2wt	207	19	interactions	interaction	NNS
cord-016300-vw11c2wt	207	20	with	with	IN
cord-016300-vw11c2wt	207	21	other	other	JJ
cord-016300-vw11c2wt	207	22	cytokines	cytokine	NNS
cord-016300-vw11c2wt	207	23	,	,	,
cord-016300-vw11c2wt	207	24	may	may	MD
cord-016300-vw11c2wt	207	25	play	play	VB
cord-016300-vw11c2wt	207	26	an	an	DT
cord-016300-vw11c2wt	207	27	important	important	JJ
cord-016300-vw11c2wt	207	28	role	role	NN
cord-016300-vw11c2wt	207	29	in	in	IN
cord-016300-vw11c2wt	207	30	increase	increase	NN
cord-016300-vw11c2wt	207	31	of	of	IN
cord-016300-vw11c2wt	207	32	airway	airway	NN
cord-016300-vw11c2wt	207	33	inflammation	inflammation	NN
cord-016300-vw11c2wt	207	34	,	,	,
cord-016300-vw11c2wt	207	35	which	which	WDT
cord-016300-vw11c2wt	207	36	is	be	VBZ
cord-016300-vw11c2wt	207	37	observed	observe	VBN
cord-016300-vw11c2wt	207	38	after	after	IN
cord-016300-vw11c2wt	207	39	postexercise	postexercise	NNP
cord-016300-vw11c2wt	207	40	bronchoconstriction	bronchoconstriction	NN
cord-016300-vw11c2wt	207	41	in	in	IN
cord-016300-vw11c2wt	207	42	asthmatic	asthmatic	JJ
cord-016300-vw11c2wt	207	43	patients	patient	NNS
cord-016300-vw11c2wt	207	44	.	.	.
cord-016300-vw11c2wt	208	1	IgE	IgE	NNP
cord-016300-vw11c2wt	208	2	plays	play	VBZ
cord-016300-vw11c2wt	208	3	a	a	DT
cord-016300-vw11c2wt	208	4	central	central	JJ
cord-016300-vw11c2wt	208	5	role	role	NN
cord-016300-vw11c2wt	208	6	in	in	IN
cord-016300-vw11c2wt	208	7	the	the	DT
cord-016300-vw11c2wt	208	8	pathophysiology	pathophysiology	NN
cord-016300-vw11c2wt	208	9	of	of	IN
cord-016300-vw11c2wt	208	10	asthma	asthma	NN
cord-016300-vw11c2wt	208	11	.	.	.
cord-016300-vw11c2wt	209	1	The	the	DT
cord-016300-vw11c2wt	209	2	two	two	CD
cord-016300-vw11c2wt	209	3	essential	essential	JJ
cord-016300-vw11c2wt	209	4	phases	phase	NNS
cord-016300-vw11c2wt	209	5	in	in	IN
cord-016300-vw11c2wt	209	6	this	this	DT
cord-016300-vw11c2wt	209	7	pathophysiology	pathophysiology	NN
cord-016300-vw11c2wt	209	8	are	be	VBP
cord-016300-vw11c2wt	209	9	sensitization	sensitization	NN
cord-016300-vw11c2wt	209	10	to	to	IN
cord-016300-vw11c2wt	209	11	allergen	allergen	NN
cord-016300-vw11c2wt	209	12	and	and	CC
cord-016300-vw11c2wt	209	13	clinical	clinical	JJ
cord-016300-vw11c2wt	209	14	expression	expression	NN
cord-016300-vw11c2wt	209	15	of	of	IN
cord-016300-vw11c2wt	209	16	symptoms	symptom	NNS
cord-016300-vw11c2wt	209	17	on	on	IN
cord-016300-vw11c2wt	209	18	reexposure	reexposure	NN
cord-016300-vw11c2wt	209	19	to	to	IN
cord-016300-vw11c2wt	209	20	the	the	DT
cord-016300-vw11c2wt	209	21	sensitizing	sensitize	VBG
cord-016300-vw11c2wt	209	22	allergen	allergen	NN
cord-016300-vw11c2wt	209	23	.	.	.
cord-016300-vw11c2wt	210	1	Omalizumab	Omalizumab	NNP
cord-016300-vw11c2wt	211	1	(	(	-LRB-
cord-016300-vw11c2wt	211	2	Xolair	Xolair	NNP
cord-016300-vw11c2wt	211	3	,	,	,
cord-016300-vw11c2wt	211	4	Genentech	Genentech	NNP
cord-016300-vw11c2wt	211	5	)	)	-RRB-
cord-016300-vw11c2wt	211	6	is	be	VBZ
cord-016300-vw11c2wt	211	7	a	a	DT
cord-016300-vw11c2wt	211	8	recombinant	recombinant	JJ
cord-016300-vw11c2wt	211	9	humanized	humanize	VBN
cord-016300-vw11c2wt	211	10	IgG1	IgG1	NNP
cord-016300-vw11c2wt	211	11	monoclonal	monoclonal	JJ
cord-016300-vw11c2wt	211	12	anti	anti	NNP
cord-016300-vw11c2wt	211	13	-	-	JJ
cord-016300-vw11c2wt	211	14	IgE	ige	JJ
cord-016300-vw11c2wt	211	15	antibody	antibody	NN
cord-016300-vw11c2wt	211	16	that	that	WDT
cord-016300-vw11c2wt	211	17	binds	bind	VBZ
cord-016300-vw11c2wt	211	18	to	to	IN
cord-016300-vw11c2wt	211	19	circulating	circulate	VBG
cord-016300-vw11c2wt	211	20	IgE	IgE	NNP
cord-016300-vw11c2wt	211	21	,	,	,
cord-016300-vw11c2wt	211	22	regardless	regardless	RB
cord-016300-vw11c2wt	211	23	of	of	IN
cord-016300-vw11c2wt	211	24	allergen	allergen	NN
cord-016300-vw11c2wt	211	25	specificity	specificity	NN
cord-016300-vw11c2wt	211	26	,	,	,
cord-016300-vw11c2wt	211	27	forming	form	VBG
cord-016300-vw11c2wt	211	28	small	small	JJ
cord-016300-vw11c2wt	211	29	,	,	,
cord-016300-vw11c2wt	211	30	biologically	biologically	RB
cord-016300-vw11c2wt	211	31	inert	inert	JJ
cord-016300-vw11c2wt	211	32	IgE	ige	JJ
cord-016300-vw11c2wt	211	33	-	-	HYPH
cord-016300-vw11c2wt	211	34	anti	anti	NNP
cord-016300-vw11c2wt	211	35	-	-	JJ
cord-016300-vw11c2wt	211	36	IgE	ige	JJ
cord-016300-vw11c2wt	211	37	complexes	complex	NNS
cord-016300-vw11c2wt	211	38	without	without	IN
cord-016300-vw11c2wt	211	39	activating	activate	VBG
cord-016300-vw11c2wt	211	40	the	the	DT
cord-016300-vw11c2wt	211	41	complement	complement	NN
cord-016300-vw11c2wt	211	42	cascade	cascade	NN
cord-016300-vw11c2wt	211	43	.	.	.
cord-016300-vw11c2wt	212	1	An	an	DT
cord-016300-vw11c2wt	212	2	89	89	CD
cord-016300-vw11c2wt	212	3	-	-	SYM
cord-016300-vw11c2wt	212	4	99	99	CD
cord-016300-vw11c2wt	212	5	%	%	NN
cord-016300-vw11c2wt	212	6	reduction	reduction	NN
cord-016300-vw11c2wt	212	7	in	in	IN
cord-016300-vw11c2wt	212	8	free	free	JJ
cord-016300-vw11c2wt	212	9	serum	serum	NN
cord-016300-vw11c2wt	212	10	IgE	IgE	NNP
cord-016300-vw11c2wt	212	11	(	(	-LRB-
cord-016300-vw11c2wt	212	12	i.e.	i.e.	FW
cord-016300-vw11c2wt	212	13	,	,	,
cord-016300-vw11c2wt	212	14	IgE	IgE	NNP
cord-016300-vw11c2wt	212	15	not	not	RB
cord-016300-vw11c2wt	212	16	bound	bind	VBN
cord-016300-vw11c2wt	212	17	to	to	IN
cord-016300-vw11c2wt	212	18	omalizumab	omalizumab	NNP
cord-016300-vw11c2wt	212	19	)	)	-RRB-
cord-016300-vw11c2wt	212	20	occurs	occur	VBZ
cord-016300-vw11c2wt	212	21	soon	soon	RB
cord-016300-vw11c2wt	212	22	after	after	IN
cord-016300-vw11c2wt	212	23	the	the	DT
cord-016300-vw11c2wt	212	24	administration	administration	NN
cord-016300-vw11c2wt	212	25	of	of	IN
cord-016300-vw11c2wt	212	26	omalizumab	omalizumab	NNP
cord-016300-vw11c2wt	212	27	,	,	,
cord-016300-vw11c2wt	212	28	and	and	CC
cord-016300-vw11c2wt	212	29	low	low	JJ
cord-016300-vw11c2wt	212	30	levels	level	NNS
cord-016300-vw11c2wt	212	31	persist	persist	VBP
cord-016300-vw11c2wt	212	32	throughout	throughout	IN
cord-016300-vw11c2wt	212	33	treatment	treatment	NN
cord-016300-vw11c2wt	212	34	with	with	IN
cord-016300-vw11c2wt	212	35	appropriate	appropriate	JJ
cord-016300-vw11c2wt	212	36	doses	dose	NNS
cord-016300-vw11c2wt	212	37	.	.	.
cord-016300-vw11c2wt	213	1	A	a	DT
cord-016300-vw11c2wt	213	2	total	total	JJ
cord-016300-vw11c2wt	213	3	serum	serum	NN
cord-016300-vw11c2wt	213	4	IgE	ige	NN
cord-016300-vw11c2wt	213	5	level	level	NN
cord-016300-vw11c2wt	213	6	should	should	MD
cord-016300-vw11c2wt	213	7	be	be	VB
cord-016300-vw11c2wt	213	8	measured	measure	VBN
cord-016300-vw11c2wt	213	9	in	in	IN
cord-016300-vw11c2wt	213	10	all	all	DT
cord-016300-vw11c2wt	213	11	patients	patient	NNS
cord-016300-vw11c2wt	213	12	who	who	WP
cord-016300-vw11c2wt	213	13	are	be	VBP
cord-016300-vw11c2wt	213	14	being	be	VBG
cord-016300-vw11c2wt	213	15	considered	consider	VBN
cord-016300-vw11c2wt	213	16	for	for	IN
cord-016300-vw11c2wt	213	17	treatment	treatment	NN
cord-016300-vw11c2wt	213	18	with	with	IN
cord-016300-vw11c2wt	213	19	omalizumab	omalizumab	NNP
cord-016300-vw11c2wt	213	20	,	,	,
cord-016300-vw11c2wt	213	21	because	because	IN
cord-016300-vw11c2wt	213	22	the	the	DT
cord-016300-vw11c2wt	213	23	dose	dose	NN
cord-016300-vw11c2wt	213	24	of	of	IN
cord-016300-vw11c2wt	213	25	omalizumab	omalizumab	NNP
cord-016300-vw11c2wt	213	26	is	be	VBZ
cord-016300-vw11c2wt	213	27	determined	determine	VBN
cord-016300-vw11c2wt	213	28	on	on	IN
cord-016300-vw11c2wt	213	29	the	the	DT
cord-016300-vw11c2wt	213	30	basis	basis	NN
cord-016300-vw11c2wt	213	31	of	of	IN
cord-016300-vw11c2wt	213	32	the	the	DT
cord-016300-vw11c2wt	213	33	IgE	IgE	NNP
cord-016300-vw11c2wt	213	34	level	level	NN
cord-016300-vw11c2wt	213	35	and	and	CC
cord-016300-vw11c2wt	213	36	body	body	NN
cord-016300-vw11c2wt	213	37	weight	weight	NN
cord-016300-vw11c2wt	213	38	.	.	.
cord-016300-vw11c2wt	214	1	The	the	DT
cord-016300-vw11c2wt	214	2	dose	dose	NN
cord-016300-vw11c2wt	214	3	is	be	VBZ
cord-016300-vw11c2wt	214	4	based	base	VBN
cord-016300-vw11c2wt	214	5	on	on	IN
cord-016300-vw11c2wt	214	6	the	the	DT
cord-016300-vw11c2wt	214	7	estimated	estimate	VBN
cord-016300-vw11c2wt	214	8	amount	amount	NN
cord-016300-vw11c2wt	214	9	of	of	IN
cord-016300-vw11c2wt	214	10	the	the	DT
cord-016300-vw11c2wt	214	11	drug	drug	NN
cord-016300-vw11c2wt	214	12	that	that	WDT
cord-016300-vw11c2wt	214	13	is	be	VBZ
cord-016300-vw11c2wt	214	14	required	require	VBN
cord-016300-vw11c2wt	214	15	to	to	TO
cord-016300-vw11c2wt	214	16	reduce	reduce	VB
cord-016300-vw11c2wt	214	17	circulating	circulate	VBG
cord-016300-vw11c2wt	214	18	free	free	JJ
cord-016300-vw11c2wt	214	19	IgE	IgE	NNP
cord-016300-vw11c2wt	214	20	levels	level	NNS
cord-016300-vw11c2wt	214	21	to	to	IN
cord-016300-vw11c2wt	214	22	less	less	JJR
cord-016300-vw11c2wt	214	23	than	than	IN
cord-016300-vw11c2wt	214	24	10	10	CD
cord-016300-vw11c2wt	214	25	IU	iu	NN
cord-016300-vw11c2wt	214	26	per	per	IN
cord-016300-vw11c2wt	214	27	milliliter	milliliter	NN
cord-016300-vw11c2wt	214	28	.	.	.
cord-016300-vw11c2wt	215	1	Lebrikizumab	Lebrikizumab	NNP
cord-016300-vw11c2wt	215	2	(	(	-LRB-
cord-016300-vw11c2wt	215	3	Roche	Roche	NNP
cord-016300-vw11c2wt	215	4	)	)	-RRB-
cord-016300-vw11c2wt	215	5	is	be	VBZ
cord-016300-vw11c2wt	215	6	an	an	DT
cord-016300-vw11c2wt	215	7	injectable	injectable	JJ
cord-016300-vw11c2wt	215	8	humanized	humanize	VBN
cord-016300-vw11c2wt	215	9	MAb	MAb	NNS
cord-016300-vw11c2wt	215	10	designed	design	VBN
cord-016300-vw11c2wt	215	11	to	to	TO
cord-016300-vw11c2wt	215	12	block	block	VB
cord-016300-vw11c2wt	215	13	IL-13	IL-13	NNP
cord-016300-vw11c2wt	215	14	,	,	,
cord-016300-vw11c2wt	215	15	which	which	WDT
cord-016300-vw11c2wt	215	16	contributes	contribute	VBZ
cord-016300-vw11c2wt	215	17	to	to	IN
cord-016300-vw11c2wt	215	18	key	key	JJ
cord-016300-vw11c2wt	215	19	features	feature	NNS
cord-016300-vw11c2wt	215	20	of	of	IN
cord-016300-vw11c2wt	215	21	asthma	asthma	NN
cord-016300-vw11c2wt	215	22	.	.	.
cord-016300-vw11c2wt	216	1	Lebrikizumab	Lebrikizumab	NNP
cord-016300-vw11c2wt	216	2	improves	improve	VBZ
cord-016300-vw11c2wt	216	3	lung	lung	NN
cord-016300-vw11c2wt	216	4	function	function	NN
cord-016300-vw11c2wt	216	5	in	in	IN
cord-016300-vw11c2wt	216	6	adult	adult	NN
cord-016300-vw11c2wt	216	7	asthma	asthma	NN
cord-016300-vw11c2wt	216	8	patients	patient	NNS
cord-016300-vw11c2wt	216	9	who	who	WP
cord-016300-vw11c2wt	216	10	are	be	VBP
cord-016300-vw11c2wt	216	11	unable	unable	JJ
cord-016300-vw11c2wt	216	12	to	to	TO
cord-016300-vw11c2wt	216	13	control	control	VB
cord-016300-vw11c2wt	216	14	their	-PRON-	PRP$
cord-016300-vw11c2wt	216	15	disease	disease	NN
cord-016300-vw11c2wt	216	16	on	on	IN
cord-016300-vw11c2wt	216	17	inhaled	inhale	VBN
cord-016300-vw11c2wt	216	18	corticosteroids	corticosteroid	NNS
cord-016300-vw11c2wt	216	19	.	.	.
cord-016300-vw11c2wt	217	1	IL-13	IL-13	NNP
cord-016300-vw11c2wt	217	2	induces	induce	VBZ
cord-016300-vw11c2wt	217	3	bronchial	bronchial	JJ
cord-016300-vw11c2wt	217	4	epithelial	epithelial	JJ
cord-016300-vw11c2wt	217	5	cells	cell	NNS
cord-016300-vw11c2wt	217	6	to	to	IN
cord-016300-vw11c2wt	217	7	secrete	secrete	VB
cord-016300-vw11c2wt	217	8	periostin	periostin	NNS
cord-016300-vw11c2wt	217	9	,	,	,
cord-016300-vw11c2wt	217	10	a	a	DT
cord-016300-vw11c2wt	217	11	matricellular	matricellular	JJ
cord-016300-vw11c2wt	217	12	protein	protein	NN
cord-016300-vw11c2wt	217	13	.	.	.
cord-016300-vw11c2wt	218	1	Increased	increase	VBN
cord-016300-vw11c2wt	218	2	levels	level	NNS
cord-016300-vw11c2wt	218	3	of	of	IN
cord-016300-vw11c2wt	218	4	periostin	periostin	NNS
cord-016300-vw11c2wt	218	5	,	,	,
cord-016300-vw11c2wt	218	6	a	a	DT
cord-016300-vw11c2wt	218	7	biomarker	biomarker	NN
cord-016300-vw11c2wt	218	8	of	of	IN
cord-016300-vw11c2wt	218	9	asthma	asthma	NN
cord-016300-vw11c2wt	218	10	,	,	,
cord-016300-vw11c2wt	218	11	can	can	MD
cord-016300-vw11c2wt	218	12	be	be	VB
cord-016300-vw11c2wt	218	13	measured	measure	VBN
cord-016300-vw11c2wt	218	14	in	in	IN
cord-016300-vw11c2wt	218	15	the	the	DT
cord-016300-vw11c2wt	218	16	blood	blood	NN
cord-016300-vw11c2wt	218	17	.	.	.
cord-016300-vw11c2wt	219	1	In	in	IN
cord-016300-vw11c2wt	219	2	the	the	DT
cord-016300-vw11c2wt	219	3	MILLY	MILLY	NNP
cord-016300-vw11c2wt	219	4	phase	phase	NN
cord-016300-vw11c2wt	219	5	II	II	NNP
cord-016300-vw11c2wt	219	6	trial	trial	NN
cord-016300-vw11c2wt	219	7	,	,	,
cord-016300-vw11c2wt	219	8	patients	patient	NNS
cord-016300-vw11c2wt	219	9	with	with	IN
cord-016300-vw11c2wt	219	10	high	high	JJ
cord-016300-vw11c2wt	219	11	pretreatment	pretreatment	NN
cord-016300-vw11c2wt	219	12	periostin	periostin	NN
cord-016300-vw11c2wt	219	13	levels	level	NNS
cord-016300-vw11c2wt	219	14	had	have	VBD
cord-016300-vw11c2wt	219	15	greater	great	JJR
cord-016300-vw11c2wt	219	16	improvement	improvement	NN
cord-016300-vw11c2wt	219	17	in	in	IN
cord-016300-vw11c2wt	219	18	lung	lung	NN
cord-016300-vw11c2wt	219	19	function	function	NN
cord-016300-vw11c2wt	219	20	when	when	WRB
cord-016300-vw11c2wt	219	21	treated	treat	VBN
cord-016300-vw11c2wt	219	22	with	with	IN
cord-016300-vw11c2wt	219	23	lebrikizumab	lebrikizumab	NNP
cord-016300-vw11c2wt	219	24	,	,	,
cord-016300-vw11c2wt	219	25	compared	compare	VBN
cord-016300-vw11c2wt	219	26	to	to	IN
cord-016300-vw11c2wt	219	27	patients	patient	NNS
cord-016300-vw11c2wt	219	28	with	with	IN
cord-016300-vw11c2wt	219	29	low	low	JJ
cord-016300-vw11c2wt	219	30	periostin	periostin	NN
cord-016300-vw11c2wt	219	31	levels	level	NNS
cord-016300-vw11c2wt	219	32	(	(	-LRB-
cord-016300-vw11c2wt	219	33	Corren	Corren	NNP
cord-016300-vw11c2wt	219	34	et	et	NNP
cord-016300-vw11c2wt	219	35	al	al	NNP
cord-016300-vw11c2wt	219	36	.	.	NNP
cord-016300-vw11c2wt	219	37	2011	2011	CD
cord-016300-vw11c2wt	219	38	)	)	-RRB-
cord-016300-vw11c2wt	220	1	.The	.The	.
cord-016300-vw11c2wt	221	1	primary	primary	JJ
cord-016300-vw11c2wt	221	2	endpoint	endpoint	NN
cord-016300-vw11c2wt	221	3	of	of	IN
cord-016300-vw11c2wt	221	4	the	the	DT
cord-016300-vw11c2wt	221	5	trial	trial	NN
cord-016300-vw11c2wt	221	6	showed	show	VBD
cord-016300-vw11c2wt	221	7	that	that	IN
cord-016300-vw11c2wt	221	8	at	at	IN
cord-016300-vw11c2wt	221	9	week	week	NN
cord-016300-vw11c2wt	221	10	12	12	CD
cord-016300-vw11c2wt	221	11	,	,	,
cord-016300-vw11c2wt	221	12	lebrikizumab	lebrikizumab	NNP
cord-016300-vw11c2wt	221	13	-	-	HYPH
cord-016300-vw11c2wt	221	14	treated	treat	VBN
cord-016300-vw11c2wt	221	15	patients	patient	NNS
cord-016300-vw11c2wt	221	16	had	have	VBD
cord-016300-vw11c2wt	221	17	a	a	DT
cord-016300-vw11c2wt	221	18	5.5	5.5	CD
cord-016300-vw11c2wt	221	19	%	%	NN
cord-016300-vw11c2wt	221	20	greater	great	JJR
cord-016300-vw11c2wt	221	21	increase	increase	NN
cord-016300-vw11c2wt	221	22	in	in	IN
cord-016300-vw11c2wt	221	23	lung	lung	NN
cord-016300-vw11c2wt	221	24	function	function	NN
cord-016300-vw11c2wt	221	25	from	from	IN
cord-016300-vw11c2wt	221	26	the	the	DT
cord-016300-vw11c2wt	221	27	baseline	baseline	NN
cord-016300-vw11c2wt	221	28	compared	compare	VBN
cord-016300-vw11c2wt	221	29	to	to	IN
cord-016300-vw11c2wt	221	30	placebo	placebo	NN
cord-016300-vw11c2wt	221	31	.	.	.
cord-016300-vw11c2wt	222	1	Lebrikizumabtreated	lebrikizumabtreated	JJ
cord-016300-vw11c2wt	222	2	patients	patient	NNS
cord-016300-vw11c2wt	222	3	in	in	IN
cord-016300-vw11c2wt	222	4	the	the	DT
cord-016300-vw11c2wt	222	5	high	high	JJ
cord-016300-vw11c2wt	222	6	-	-	HYPH
cord-016300-vw11c2wt	222	7	periostin	periostin	NN
cord-016300-vw11c2wt	222	8	subgroup	subgroup	NN
cord-016300-vw11c2wt	222	9	experienced	experience	VBD
cord-016300-vw11c2wt	222	10	an	an	DT
cord-016300-vw11c2wt	222	11	8.2	8.2	CD
cord-016300-vw11c2wt	222	12	%	%	NN
cord-016300-vw11c2wt	222	13	relative	relative	JJ
cord-016300-vw11c2wt	222	14	increase	increase	NN
cord-016300-vw11c2wt	222	15	from	from	IN
cord-016300-vw11c2wt	222	16	baseline	baseline	JJ
cord-016300-vw11c2wt	222	17	forced	force	VBN
cord-016300-vw11c2wt	222	18	expiratory	expiratory	JJ
cord-016300-vw11c2wt	222	19	volume	volume	NN
cord-016300-vw11c2wt	222	20	in	in	IN
cord-016300-vw11c2wt	222	21	1	1	CD
cord-016300-vw11c2wt	222	22	second	second	NN
cord-016300-vw11c2wt	222	23	(	(	-LRB-
cord-016300-vw11c2wt	222	24	FEV1	FEV1	NNP
cord-016300-vw11c2wt	222	25	)	)	-RRB-
cord-016300-vw11c2wt	222	26	,	,	,
cord-016300-vw11c2wt	222	27	compared	compare	VBN
cord-016300-vw11c2wt	222	28	with	with	IN
cord-016300-vw11c2wt	222	29	placebo	placebo	NN
cord-016300-vw11c2wt	222	30	.	.	.
cord-016300-vw11c2wt	223	1	In	in	IN
cord-016300-vw11c2wt	223	2	the	the	DT
cord-016300-vw11c2wt	223	3	low	low	JJ
cord-016300-vw11c2wt	223	4	-	-	HYPH
cord-016300-vw11c2wt	223	5	periostin	periostin	NN
cord-016300-vw11c2wt	223	6	subgroup	subgroup	NN
cord-016300-vw11c2wt	223	7	,	,	,
cord-016300-vw11c2wt	223	8	those	those	DT
cord-016300-vw11c2wt	223	9	patients	patient	NNS
cord-016300-vw11c2wt	223	10	on	on	IN
cord-016300-vw11c2wt	223	11	the	the	DT
cord-016300-vw11c2wt	223	12	drug	drug	NN
cord-016300-vw11c2wt	223	13	experienced	experience	VBD
cord-016300-vw11c2wt	223	14	a	a	DT
cord-016300-vw11c2wt	223	15	1.6	1.6	CD
cord-016300-vw11c2wt	223	16	%	%	NN
cord-016300-vw11c2wt	223	17	relative	relative	JJ
cord-016300-vw11c2wt	223	18	increase	increase	NN
cord-016300-vw11c2wt	223	19	in	in	IN
cord-016300-vw11c2wt	223	20	FEV1	FEV1	NNP
cord-016300-vw11c2wt	223	21	,	,	,
cord-016300-vw11c2wt	223	22	compared	compare	VBN
cord-016300-vw11c2wt	223	23	with	with	IN
cord-016300-vw11c2wt	223	24	placebo	placebo	NN
cord-016300-vw11c2wt	223	25	.	.	.
cord-016300-vw11c2wt	224	1	These	these	DT
cord-016300-vw11c2wt	224	2	results	result	NNS
cord-016300-vw11c2wt	224	3	support	support	VBP
cord-016300-vw11c2wt	224	4	further	further	JJ
cord-016300-vw11c2wt	224	5	investigation	investigation	NN
cord-016300-vw11c2wt	224	6	of	of	IN
cord-016300-vw11c2wt	224	7	lebrikizumab	lebrikizumab	NNP
cord-016300-vw11c2wt	224	8	as	as	IN
cord-016300-vw11c2wt	224	9	a	a	DT
cord-016300-vw11c2wt	224	10	personalized	personalized	JJ
cord-016300-vw11c2wt	224	11	medicine	medicine	NN
cord-016300-vw11c2wt	224	12	for	for	IN
cord-016300-vw11c2wt	224	13	patients	patient	NNS
cord-016300-vw11c2wt	224	14	who	who	WP
cord-016300-vw11c2wt	224	15	suffer	suffer	VBP
cord-016300-vw11c2wt	224	16	from	from	IN
cord-016300-vw11c2wt	224	17	moderate	moderate	JJ
cord-016300-vw11c2wt	224	18	to	to	TO
cord-016300-vw11c2wt	224	19	severe	severe	JJ
cord-016300-vw11c2wt	224	20	uncontrolled	uncontrolled	JJ
cord-016300-vw11c2wt	224	21	asthma	asthma	NN
cord-016300-vw11c2wt	224	22	periostin	periostin	NNS
cord-016300-vw11c2wt	224	23	enables	enable	VBZ
cord-016300-vw11c2wt	224	24	selection	selection	NN
cord-016300-vw11c2wt	224	25	of	of	IN
cord-016300-vw11c2wt	224	26	patients	patient	NNS
cord-016300-vw11c2wt	224	27	who	who	WP
cord-016300-vw11c2wt	224	28	will	will	MD
cord-016300-vw11c2wt	224	29	benefit	benefit	VB
cord-016300-vw11c2wt	224	30	most	most	JJS
cord-016300-vw11c2wt	224	31	from	from	IN
cord-016300-vw11c2wt	224	32	the	the	DT
cord-016300-vw11c2wt	224	33	drug	drug	NN
cord-016300-vw11c2wt	224	34	.	.	.
cord-016300-vw11c2wt	225	1	Cystic	cystic	JJ
cord-016300-vw11c2wt	225	2	fibrosis	fibrosis	NN
cord-016300-vw11c2wt	225	3	(	(	-LRB-
cord-016300-vw11c2wt	225	4	CF	CF	NNP
cord-016300-vw11c2wt	225	5	)	)	-RRB-
cord-016300-vw11c2wt	225	6	is	be	VBZ
cord-016300-vw11c2wt	225	7	the	the	DT
cord-016300-vw11c2wt	225	8	most	most	RBS
cord-016300-vw11c2wt	225	9	common	common	JJ
cord-016300-vw11c2wt	225	10	serious	serious	JJ
cord-016300-vw11c2wt	225	11	genetic	genetic	JJ
cord-016300-vw11c2wt	225	12	disease	disease	NN
cord-016300-vw11c2wt	225	13	among	among	IN
cord-016300-vw11c2wt	225	14	Caucasians	Caucasians	NNPS
cord-016300-vw11c2wt	225	15	in	in	IN
cord-016300-vw11c2wt	225	16	the	the	DT
cord-016300-vw11c2wt	225	17	US	US	NNP
cord-016300-vw11c2wt	225	18	.	.	.
cord-016300-vw11c2wt	226	1	The	the	DT
cord-016300-vw11c2wt	226	2	disease	disease	NN
cord-016300-vw11c2wt	226	3	results	result	VBZ
cord-016300-vw11c2wt	226	4	from	from	IN
cord-016300-vw11c2wt	226	5	a	a	DT
cord-016300-vw11c2wt	226	6	defective	defective	JJ
cord-016300-vw11c2wt	226	7	gene	gene	NN
cord-016300-vw11c2wt	226	8	that	that	WDT
cord-016300-vw11c2wt	226	9	affects	affect	VBZ
cord-016300-vw11c2wt	226	10	multiple	multiple	JJ
cord-016300-vw11c2wt	226	11	aspects	aspect	NNS
cord-016300-vw11c2wt	226	12	of	of	IN
cord-016300-vw11c2wt	226	13	cellular	cellular	JJ
cord-016300-vw11c2wt	226	14	function	function	NN
cord-016300-vw11c2wt	226	15	.	.	.
cord-016300-vw11c2wt	227	1	Its	-PRON-	PRP$
cord-016300-vw11c2wt	227	2	most	most	RBS
cord-016300-vw11c2wt	227	3	serious	serious	JJ
cord-016300-vw11c2wt	227	4	symptom	symptom	NN
cord-016300-vw11c2wt	227	5	is	be	VBZ
cord-016300-vw11c2wt	227	6	a	a	DT
cord-016300-vw11c2wt	227	7	build	build	NN
cord-016300-vw11c2wt	227	8	-	-	HYPH
cord-016300-vw11c2wt	227	9	up	up	NN
cord-016300-vw11c2wt	227	10	of	of	IN
cord-016300-vw11c2wt	227	11	thick	thick	JJ
cord-016300-vw11c2wt	227	12	,	,	,
cord-016300-vw11c2wt	227	13	sticky	sticky	JJ
cord-016300-vw11c2wt	227	14	mucus	mucus	NN
cord-016300-vw11c2wt	227	15	in	in	IN
cord-016300-vw11c2wt	227	16	the	the	DT
cord-016300-vw11c2wt	227	17	airways	airway	NNS
cord-016300-vw11c2wt	227	18	,	,	,
cord-016300-vw11c2wt	227	19	which	which	WDT
cord-016300-vw11c2wt	227	20	can	can	MD
cord-016300-vw11c2wt	227	21	lead	lead	VB
cord-016300-vw11c2wt	227	22	to	to	IN
cord-016300-vw11c2wt	227	23	fatal	fatal	JJ
cord-016300-vw11c2wt	227	24	lung	lung	NN
cord-016300-vw11c2wt	227	25	infections	infection	NNS
cord-016300-vw11c2wt	227	26	.	.	.
cord-016300-vw11c2wt	228	1	The	the	DT
cord-016300-vw11c2wt	228	2	usual	usual	JJ
cord-016300-vw11c2wt	228	3	method	method	NN
cord-016300-vw11c2wt	228	4	for	for	IN
cord-016300-vw11c2wt	228	5	screening	screening	NN
cord-016300-vw11c2wt	228	6	and	and	CC
cord-016300-vw11c2wt	228	7	diagnosis	diagnosis	NN
cord-016300-vw11c2wt	228	8	is	be	VBZ
cord-016300-vw11c2wt	228	9	genotyping	genotype	VBG
cord-016300-vw11c2wt	228	10	of	of	IN
cord-016300-vw11c2wt	228	11	cystic	cystic	JJ
cord-016300-vw11c2wt	228	12	fibrosis	fibrosis	NN
cord-016300-vw11c2wt	228	13	transmembrane	transmembrane	NNP
cord-016300-vw11c2wt	228	14	conductance	conductance	NN
cord-016300-vw11c2wt	228	15	regulator	regulator	NN
cord-016300-vw11c2wt	228	16	(	(	-LRB-
cord-016300-vw11c2wt	228	17	CFTR	CFTR	NNP
cord-016300-vw11c2wt	228	18	)	)	-RRB-
cord-016300-vw11c2wt	228	19	gene	gene	NN
cord-016300-vw11c2wt	228	20	mutations	mutation	NNS
cord-016300-vw11c2wt	228	21	.	.	.
cord-016300-vw11c2wt	229	1	Antibody	antibody	NN
cord-016300-vw11c2wt	229	2	microarrays	microarray	NNS
cord-016300-vw11c2wt	229	3	have	have	VBP
cord-016300-vw11c2wt	229	4	been	be	VBN
cord-016300-vw11c2wt	229	5	developed	develop	VBN
cord-016300-vw11c2wt	229	6	as	as	IN
cord-016300-vw11c2wt	229	7	a	a	DT
cord-016300-vw11c2wt	229	8	platform	platform	NN
cord-016300-vw11c2wt	229	9	for	for	IN
cord-016300-vw11c2wt	229	10	identifying	identify	VBG
cord-016300-vw11c2wt	229	11	a	a	DT
cord-016300-vw11c2wt	229	12	CF	cf	NN
cord-016300-vw11c2wt	229	13	-	-	HYPH
cord-016300-vw11c2wt	229	14	specific	specific	JJ
cord-016300-vw11c2wt	229	15	serum	serum	NN
cord-016300-vw11c2wt	229	16	proteomic	proteomic	NN
cord-016300-vw11c2wt	229	17	signature	signature	NN
cord-016300-vw11c2wt	229	18	.	.	.
cord-016300-vw11c2wt	230	1	Serum	serum	NN
cord-016300-vw11c2wt	230	2	samples	sample	NNS
cord-016300-vw11c2wt	230	3	from	from	IN
cord-016300-vw11c2wt	230	4	CF	cf	NN
cord-016300-vw11c2wt	230	5	patients	patient	NNS
cord-016300-vw11c2wt	230	6	have	have	VBP
cord-016300-vw11c2wt	230	7	been	be	VBN
cord-016300-vw11c2wt	230	8	pooled	pool	VBN
cord-016300-vw11c2wt	230	9	and	and	CC
cord-016300-vw11c2wt	230	10	compared	compare	VBN
cord-016300-vw11c2wt	230	11	with	with	IN
cord-016300-vw11c2wt	230	12	equivalent	equivalent	JJ
cord-016300-vw11c2wt	230	13	pools	pool	NNS
cord-016300-vw11c2wt	230	14	of	of	IN
cord-016300-vw11c2wt	230	15	control	control	NNP
cord-016300-vw11c2wt	230	16	sera	sera	NNP
cord-016300-vw11c2wt	230	17	in	in	IN
cord-016300-vw11c2wt	230	18	order	order	NN
cord-016300-vw11c2wt	230	19	to	to	TO
cord-016300-vw11c2wt	230	20	identify	identify	VB
cord-016300-vw11c2wt	230	21	patterns	pattern	NNS
cord-016300-vw11c2wt	230	22	of	of	IN
cord-016300-vw11c2wt	230	23	protein	protein	NN
cord-016300-vw11c2wt	230	24	expression	expression	NN
cord-016300-vw11c2wt	230	25	unique	unique	JJ
cord-016300-vw11c2wt	230	26	to	to	IN
cord-016300-vw11c2wt	230	27	CF	CF	NNP
cord-016300-vw11c2wt	230	28	.	.	.
cord-016300-vw11c2wt	231	1	The	the	DT
cord-016300-vw11c2wt	231	2	set	set	NN
cord-016300-vw11c2wt	231	3	of	of	IN
cord-016300-vw11c2wt	231	4	significantly	significantly	RB
cord-016300-vw11c2wt	231	5	differentially	differentially	RB
cord-016300-vw11c2wt	231	6	expressed	express	VBN
cord-016300-vw11c2wt	231	7	proteins	protein	NNS
cord-016300-vw11c2wt	231	8	is	be	VBZ
cord-016300-vw11c2wt	231	9	enriched	enrich	VBN
cord-016300-vw11c2wt	231	10	in	in	IN
cord-016300-vw11c2wt	231	11	protein	protein	NN
cord-016300-vw11c2wt	231	12	mediators	mediator	NNS
cord-016300-vw11c2wt	231	13	of	of	IN
cord-016300-vw11c2wt	231	14	inflammation	inflammation	NN
cord-016300-vw11c2wt	231	15	from	from	IN
cord-016300-vw11c2wt	231	16	the	the	DT
cord-016300-vw11c2wt	231	17	NFkappaB	NFkappaB	NNP
cord-016300-vw11c2wt	231	18	signaling	signal	VBG
cord-016300-vw11c2wt	231	19	pathway	pathway	NN
cord-016300-vw11c2wt	231	20	,	,	,
cord-016300-vw11c2wt	231	21	and	and	CC
cord-016300-vw11c2wt	231	22	in	in	IN
cord-016300-vw11c2wt	231	23	proteins	protein	NNS
cord-016300-vw11c2wt	231	24	that	that	WDT
cord-016300-vw11c2wt	231	25	may	may	MD
cord-016300-vw11c2wt	231	26	be	be	VB
cord-016300-vw11c2wt	231	27	selectively	selectively	RB
cord-016300-vw11c2wt	231	28	expressed	express	VBN
cord-016300-vw11c2wt	231	29	in	in	IN
cord-016300-vw11c2wt	231	30	CF	cf	NN
cord-016300-vw11c2wt	231	31	-	-	HYPH
cord-016300-vw11c2wt	231	32	affected	affect	VBN
cord-016300-vw11c2wt	231	33	tissues	tissue	NNS
cord-016300-vw11c2wt	231	34	such	such	JJ
cord-016300-vw11c2wt	231	35	as	as	IN
cord-016300-vw11c2wt	231	36	lung	lung	NN
cord-016300-vw11c2wt	231	37	and	and	CC
cord-016300-vw11c2wt	231	38	intestine	intestine	NN
cord-016300-vw11c2wt	231	39	.	.	.
cord-016300-vw11c2wt	232	1	In	in	IN
cord-016300-vw11c2wt	232	2	several	several	JJ
cord-016300-vw11c2wt	232	3	instances	instance	NNS
cord-016300-vw11c2wt	232	4	,	,	,
cord-016300-vw11c2wt	232	5	the	the	DT
cord-016300-vw11c2wt	232	6	data	datum	NNS
cord-016300-vw11c2wt	232	7	from	from	IN
cord-016300-vw11c2wt	232	8	the	the	DT
cord-016300-vw11c2wt	232	9	antibody	antibody	NN
cord-016300-vw11c2wt	232	10	microarrays	microarray	NNS
cord-016300-vw11c2wt	232	11	can	can	MD
cord-016300-vw11c2wt	232	12	be	be	VB
cord-016300-vw11c2wt	232	13	validated	validate	VBN
cord-016300-vw11c2wt	232	14	by	by	IN
cord-016300-vw11c2wt	232	15	quantitative	quantitative	JJ
cord-016300-vw11c2wt	232	16	analysis	analysis	NN
cord-016300-vw11c2wt	232	17	with	with	IN
cord-016300-vw11c2wt	232	18	Reverse	Reverse	NNP
cord-016300-vw11c2wt	232	19	Capture	Capture	NNP
cord-016300-vw11c2wt	232	20	Protein	Protein	NNP
cord-016300-vw11c2wt	232	21	Microarrays	Microarrays	NNP
cord-016300-vw11c2wt	232	22	.	.	.
cord-016300-vw11c2wt	233	1	In	in	IN
cord-016300-vw11c2wt	233	2	conclusion	conclusion	NN
cord-016300-vw11c2wt	233	3	,	,	,
cord-016300-vw11c2wt	233	4	antibody	antibody	NN
cord-016300-vw11c2wt	233	5	microarray	microarray	NN
cord-016300-vw11c2wt	233	6	technology	technology	NN
cord-016300-vw11c2wt	233	7	is	be	VBZ
cord-016300-vw11c2wt	233	8	sensitive	sensitive	JJ
cord-016300-vw11c2wt	233	9	,	,	,
cord-016300-vw11c2wt	233	10	quantitative	quantitative	JJ
cord-016300-vw11c2wt	233	11	,	,	,
cord-016300-vw11c2wt	233	12	and	and	CC
cord-016300-vw11c2wt	233	13	robust	robust	JJ
cord-016300-vw11c2wt	233	14	,	,	,
cord-016300-vw11c2wt	233	15	and	and	CC
cord-016300-vw11c2wt	233	16	can	can	MD
cord-016300-vw11c2wt	233	17	be	be	VB
cord-016300-vw11c2wt	233	18	useful	useful	JJ
cord-016300-vw11c2wt	233	19	as	as	IN
cord-016300-vw11c2wt	233	20	a	a	DT
cord-016300-vw11c2wt	233	21	proteomic	proteomic	JJ
cord-016300-vw11c2wt	233	22	platform	platform	NN
cord-016300-vw11c2wt	233	23	to	to	TO
cord-016300-vw11c2wt	233	24	discriminate	discriminate	VB
cord-016300-vw11c2wt	233	25	between	between	IN
cord-016300-vw11c2wt	233	26	sera	sera	NNP
cord-016300-vw11c2wt	233	27	from	from	IN
cord-016300-vw11c2wt	233	28	CF	CF	NNP
cord-016300-vw11c2wt	233	29	and	and	CC
cord-016300-vw11c2wt	233	30	control	control	NN
cord-016300-vw11c2wt	233	31	patients	patient	NNS
cord-016300-vw11c2wt	233	32	.	.	.
cord-016300-vw11c2wt	234	1	Saliva	saliva	NN
cord-016300-vw11c2wt	234	2	,	,	,
cord-016300-vw11c2wt	234	3	because	because	IN
cord-016300-vw11c2wt	234	4	of	of	IN
cord-016300-vw11c2wt	234	5	the	the	DT
cord-016300-vw11c2wt	234	6	noninvasive	noninvasive	JJ
cord-016300-vw11c2wt	234	7	collection	collection	NN
cord-016300-vw11c2wt	234	8	process	process	NN
cord-016300-vw11c2wt	234	9	,	,	,
cord-016300-vw11c2wt	234	10	shows	show	VBZ
cord-016300-vw11c2wt	234	11	great	great	JJ
cord-016300-vw11c2wt	234	12	potential	potential	NN
cord-016300-vw11c2wt	234	13	as	as	IN
cord-016300-vw11c2wt	234	14	a	a	DT
cord-016300-vw11c2wt	234	15	biological	biological	JJ
cord-016300-vw11c2wt	234	16	fluid	fluid	NN
cord-016300-vw11c2wt	234	17	for	for	IN
cord-016300-vw11c2wt	234	18	CF	cf	NN
cord-016300-vw11c2wt	234	19	monitoring	monitoring	NN
cord-016300-vw11c2wt	234	20	.	.	.
cord-016300-vw11c2wt	235	1	Extensive	extensive	JJ
cord-016300-vw11c2wt	235	2	protein	protein	NN
cord-016300-vw11c2wt	235	3	degradation	degradation	NN
cord-016300-vw11c2wt	235	4	and	and	CC
cord-016300-vw11c2wt	235	5	differentially	differentially	RB
cord-016300-vw11c2wt	235	6	expressed	express	VBN
cord-016300-vw11c2wt	235	7	proteins	protein	NNS
cord-016300-vw11c2wt	235	8	have	have	VBP
cord-016300-vw11c2wt	235	9	been	be	VBN
cord-016300-vw11c2wt	235	10	identified	identify	VBN
cord-016300-vw11c2wt	235	11	in	in	IN
cord-016300-vw11c2wt	235	12	sputum	sputum	NN
cord-016300-vw11c2wt	235	13	as	as	IN
cord-016300-vw11c2wt	235	14	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	235	15	of	of	IN
cord-016300-vw11c2wt	235	16	inflammation	inflammation	NN
cord-016300-vw11c2wt	235	17	relating	relate	VBG
cord-016300-vw11c2wt	235	18	to	to	IN
cord-016300-vw11c2wt	235	19	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	235	20	exacerbations	exacerbation	NNS
cord-016300-vw11c2wt	235	21	of	of	IN
cord-016300-vw11c2wt	235	22	CF	CF	NNP
cord-016300-vw11c2wt	235	23	.	.	.
cord-016300-vw11c2wt	236	1	Use	use	NN
cord-016300-vw11c2wt	236	2	of	of	IN
cord-016300-vw11c2wt	236	3	fiber	fiber	NN
cord-016300-vw11c2wt	236	4	microarrays	microarray	NNS
cord-016300-vw11c2wt	236	5	for	for	IN
cord-016300-vw11c2wt	236	6	measuring	measure	VBG
cord-016300-vw11c2wt	236	7	significant	significant	JJ
cord-016300-vw11c2wt	236	8	variations	variation	NNS
cord-016300-vw11c2wt	236	9	of	of	IN
cord-016300-vw11c2wt	236	10	the	the	DT
cord-016300-vw11c2wt	236	11	levels	level	NNS
cord-016300-vw11c2wt	236	12	of	of	IN
cord-016300-vw11c2wt	236	13	six	six	CD
cord-016300-vw11c2wt	236	14	proteins	protein	NNS
cord-016300-vw11c2wt	236	15	in	in	IN
cord-016300-vw11c2wt	236	16	saliva	saliva	NN
cord-016300-vw11c2wt	236	17	supernatants	supernatant	NNS
cord-016300-vw11c2wt	237	1	-VEGF	-VEGF	:
cord-016300-vw11c2wt	237	2	,	,	,
cord-016300-vw11c2wt	237	3	MMP-9	MMP-9	NNP
cord-016300-vw11c2wt	237	4	,	,	,
cord-016300-vw11c2wt	238	1	IP-10	IP-10	NNP
cord-016300-vw11c2wt	238	2	,	,	,
cord-016300-vw11c2wt	238	3	IL-8	IL-8	NNP
cord-016300-vw11c2wt	238	4	,	,	,
cord-016300-vw11c2wt	238	5	IL-1β	IL-1β	NNP
cord-016300-vw11c2wt	238	6	and	and	CC
cord-016300-vw11c2wt	238	7	EGF	EGF	NNP
cord-016300-vw11c2wt	238	8	-as	-as	ADD
cord-016300-vw11c2wt	239	1	well	well	UH
cord-016300-vw11c2wt	239	2	as	as	IN
cord-016300-vw11c2wt	239	3	the	the	DT
cord-016300-vw11c2wt	239	4	correlations	correlation	NNS
cord-016300-vw11c2wt	239	5	of	of	IN
cord-016300-vw11c2wt	239	6	these	these	DT
cord-016300-vw11c2wt	239	7	levels	level	NNS
cord-016300-vw11c2wt	239	8	with	with	IN
cord-016300-vw11c2wt	239	9	clinical	clinical	JJ
cord-016300-vw11c2wt	239	10	assessments	assessment	NNS
cord-016300-vw11c2wt	239	11	,	,	,
cord-016300-vw11c2wt	239	12	has	have	VBZ
cord-016300-vw11c2wt	239	13	demonstrated	demonstrate	VBN
cord-016300-vw11c2wt	239	14	the	the	DT
cord-016300-vw11c2wt	239	15	value	value	NN
cord-016300-vw11c2wt	239	16	of	of	IN
cord-016300-vw11c2wt	239	17	saliva	saliva	NN
cord-016300-vw11c2wt	239	18	for	for	IN
cord-016300-vw11c2wt	239	19	CF	cf	NN
cord-016300-vw11c2wt	239	20	research	research	NN
cord-016300-vw11c2wt	239	21	and	and	CC
cord-016300-vw11c2wt	239	22	monitoring	monitoring	NN
cord-016300-vw11c2wt	239	23	(	(	-LRB-
cord-016300-vw11c2wt	239	24	Nie	Nie	NNP
cord-016300-vw11c2wt	239	25	et	et	NNP
cord-016300-vw11c2wt	239	26	al	al	NNP
cord-016300-vw11c2wt	239	27	.	.	NNP
cord-016300-vw11c2wt	239	28	2015	2015	CD
cord-016300-vw11c2wt	239	29	)	)	-RRB-
cord-016300-vw11c2wt	239	30	.	.	.
cord-016300-vw11c2wt	240	1	The	the	DT
cord-016300-vw11c2wt	240	2	ProHOSP	prohosp	NN
cord-016300-vw11c2wt	240	3	study	study	NN
cord-016300-vw11c2wt	240	4	group	group	NN
cord-016300-vw11c2wt	240	5	.	.	.
cord-016300-vw11c2wt	241	1	Clinical	clinical	JJ
cord-016300-vw11c2wt	241	2	risk	risk	NN
cord-016300-vw11c2wt	241	3	scores	score	NNS
cord-016300-vw11c2wt	241	4	and	and	CC
cord-016300-vw11c2wt	241	5	blood	blood	NN
cord-016300-vw11c2wt	241	6	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	241	7	as	as	IN
cord-016300-vw11c2wt	241	8	predictors	predictor	NNS
cord-016300-vw11c2wt	241	9	of	of	IN
cord-016300-vw11c2wt	241	10	long	long	JJ
cord-016300-vw11c2wt	241	11	-	-	HYPH
cord-016300-vw11c2wt	241	12	term	term	NN
cord-016300-vw11c2wt	241	13	outcome	outcome	NN
cord-016300-vw11c2wt	241	14	in	in	IN
cord-016300-vw11c2wt	241	15	patients	patient	NNS
cord-016300-vw11c2wt	241	16	with	with	IN
cord-016300-vw11c2wt	241	17	community	community	NN
cord-016300-vw11c2wt	241	18	-	-	HYPH
cord-016300-vw11c2wt	241	19	acquired	acquire	VBN
cord-016300-vw11c2wt	241	20	pneumonia	pneumonia	NN
cord-016300-vw11c2wt	241	21	:	:	:
cord-016300-vw11c2wt	241	22	a	a	DT
cord-016300-vw11c2wt	241	23	6-year	6-year	JJ
cord-016300-vw11c2wt	241	24	prospective	prospective	JJ
cord-016300-vw11c2wt	241	25	follow	follow	NN
cord-016300-vw11c2wt	241	26	-	-	HYPH
cord-016300-vw11c2wt	241	27	up	up	NN
cord-016300-vw11c2wt	241	28	study	study	NN
cord-016300-vw11c2wt	241	29	Peripheral	peripheral	JJ
cord-016300-vw11c2wt	241	30	blood	blood	NN
cord-016300-vw11c2wt	241	31	gene	gene	NN
cord-016300-vw11c2wt	241	32	expression	expression	NN
cord-016300-vw11c2wt	241	33	profiles	profile	NNS
cord-016300-vw11c2wt	241	34	in	in	IN
cord-016300-vw11c2wt	241	35	COPD	COPD	NNP
cord-016300-vw11c2wt	241	36	subjects	subject	NNS
cord-016300-vw11c2wt	241	37	Biomarkers	Biomarkers	NNPS
cord-016300-vw11c2wt	241	38	of	of	IN
cord-016300-vw11c2wt	241	39	extracellular	extracellular	JJ
cord-016300-vw11c2wt	241	40	matrix	matrix	NN
cord-016300-vw11c2wt	241	41	turnover	turnover	NN
cord-016300-vw11c2wt	241	42	are	be	VBP
cord-016300-vw11c2wt	241	43	associated	associate	VBN
cord-016300-vw11c2wt	241	44	with	with	IN
cord-016300-vw11c2wt	241	45	emphysema	emphysema	NN
cord-016300-vw11c2wt	241	46	and	and	CC
cord-016300-vw11c2wt	241	47	eosinophilic	eosinophilic	JJ
cord-016300-vw11c2wt	241	48	-	-	HYPH
cord-016300-vw11c2wt	241	49	bronchitis	bronchitis	NN
cord-016300-vw11c2wt	241	50	in	in	IN
cord-016300-vw11c2wt	241	51	COPD	COPD	NNP
cord-016300-vw11c2wt	241	52	Increased	increase	VBN
cord-016300-vw11c2wt	241	53	expression	expression	NN
cord-016300-vw11c2wt	241	54	of	of	IN
cord-016300-vw11c2wt	241	55	placenta	placenta	NN
cord-016300-vw11c2wt	241	56	growth	growth	NN
cord-016300-vw11c2wt	241	57	factor	factor	NN
cord-016300-vw11c2wt	241	58	in	in	IN
cord-016300-vw11c2wt	241	59	chronic	chronic	JJ
cord-016300-vw11c2wt	241	60	obstructive	obstructive	JJ
cord-016300-vw11c2wt	241	61	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	241	62	disease	disease	NN
cord-016300-vw11c2wt	242	1	Temporal	temporal	JJ
cord-016300-vw11c2wt	242	2	changes	change	NNS
cord-016300-vw11c2wt	242	3	in	in	IN
cord-016300-vw11c2wt	242	4	cytokine	cytokine	NN
cord-016300-vw11c2wt	242	5	/	/	SYM
cord-016300-vw11c2wt	242	6	chemokine	chemokine	NN
cord-016300-vw11c2wt	242	7	profiles	profile	NNS
cord-016300-vw11c2wt	242	8	and	and	CC
cord-016300-vw11c2wt	242	9	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	242	10	involvement	involvement	NN
cord-016300-vw11c2wt	242	11	in	in	IN
cord-016300-vw11c2wt	242	12	severe	severe	JJ
cord-016300-vw11c2wt	242	13	acute	acute	JJ
cord-016300-vw11c2wt	242	14	respiratory	respiratory	JJ
cord-016300-vw11c2wt	242	15	syndrome	syndrome	NN
cord-016300-vw11c2wt	242	16	Lebrikizumab	Lebrikizumab	NNP
cord-016300-vw11c2wt	242	17	treatment	treatment	NN
cord-016300-vw11c2wt	242	18	in	in	IN
cord-016300-vw11c2wt	242	19	adults	adult	NNS
cord-016300-vw11c2wt	242	20	with	with	IN
cord-016300-vw11c2wt	242	21	asthma	asthma	NN
cord-016300-vw11c2wt	242	22	KL-6	KL-6	NNP
cord-016300-vw11c2wt	242	23	:	:	:
cord-016300-vw11c2wt	242	24	a	a	DT
cord-016300-vw11c2wt	242	25	serological	serological	JJ
cord-016300-vw11c2wt	242	26	biomarker	biomarker	NN
cord-016300-vw11c2wt	242	27	for	for	IN
cord-016300-vw11c2wt	242	28	interstitial	interstitial	JJ
cord-016300-vw11c2wt	242	29	lung	lung	NN
cord-016300-vw11c2wt	242	30	disease	disease	NN
cord-016300-vw11c2wt	242	31	in	in	IN
cord-016300-vw11c2wt	242	32	patients	patient	NNS
cord-016300-vw11c2wt	242	33	with	with	IN
cord-016300-vw11c2wt	242	34	polymyositis	polymyositis	NNP
cord-016300-vw11c2wt	242	35	and	and	CC
cord-016300-vw11c2wt	242	36	dermatomyositis	dermatomyositis	NNP
cord-016300-vw11c2wt	242	37	Exhaled	exhale	VBD
cord-016300-vw11c2wt	242	38	nitric	nitric	NN
cord-016300-vw11c2wt	242	39	oxide	oxide	NN
cord-016300-vw11c2wt	242	40	levels	level	NNS
cord-016300-vw11c2wt	242	41	in	in	IN
cord-016300-vw11c2wt	242	42	patients	patient	NNS
cord-016300-vw11c2wt	242	43	with	with	IN
cord-016300-vw11c2wt	242	44	atopic	atopic	JJ
cord-016300-vw11c2wt	242	45	cough	cough	NN
cord-016300-vw11c2wt	242	46	and	and	CC
cord-016300-vw11c2wt	242	47	cough	cough	NN
cord-016300-vw11c2wt	242	48	variant	variant	JJ
cord-016300-vw11c2wt	242	49	asthma	asthma	NN
cord-016300-vw11c2wt	242	50	Serum	serum	NN
cord-016300-vw11c2wt	242	51	and	and	CC
cord-016300-vw11c2wt	242	52	bronchial	bronchial	JJ
cord-016300-vw11c2wt	242	53	lavage	lavage	NN
cord-016300-vw11c2wt	242	54	fluid	fluid	NN
cord-016300-vw11c2wt	242	55	concentrations	concentration	NNS
cord-016300-vw11c2wt	242	56	of	of	IN
cord-016300-vw11c2wt	242	57	IL-8	IL-8	NNP
cord-016300-vw11c2wt	242	58	,	,	,
cord-016300-vw11c2wt	242	59	SLPI	SLPI	NNP
cord-016300-vw11c2wt	242	60	,	,	,
cord-016300-vw11c2wt	242	61	sCD14	scd14	NN
cord-016300-vw11c2wt	242	62	and	and	CC
cord-016300-vw11c2wt	242	63	sICAM-1	sICAM-1	NNP
cord-016300-vw11c2wt	242	64	in	in	IN
cord-016300-vw11c2wt	242	65	patients	patient	NNS
cord-016300-vw11c2wt	242	66	with	with	IN
cord-016300-vw11c2wt	242	67	COPD	COPD	NNP
cord-016300-vw11c2wt	242	68	and	and	CC
cord-016300-vw11c2wt	242	69	asthma	asthma	NNP
cord-016300-vw11c2wt	242	70	Association	Association	NNP
cord-016300-vw11c2wt	242	71	of	of	IN
cord-016300-vw11c2wt	242	72	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	242	73	of	of	IN
cord-016300-vw11c2wt	242	74	inflammation	inflammation	NN
cord-016300-vw11c2wt	242	75	and	and	CC
cord-016300-vw11c2wt	242	76	cell	cell	NN
cord-016300-vw11c2wt	242	77	adhesion	adhesion	NN
cord-016300-vw11c2wt	242	78	with	with	IN
cord-016300-vw11c2wt	242	79	lung	lung	NN
cord-016300-vw11c2wt	242	80	function	function	NN
cord-016300-vw11c2wt	242	81	in	in	IN
cord-016300-vw11c2wt	242	82	the	the	DT
cord-016300-vw11c2wt	242	83	elderly	elderly	JJ
cord-016300-vw11c2wt	242	84	:	:	:
cord-016300-vw11c2wt	242	85	a	a	DT
cord-016300-vw11c2wt	242	86	population	population	NN
cord-016300-vw11c2wt	242	87	-	-	HYPH
cord-016300-vw11c2wt	242	88	based	base	VBN
cord-016300-vw11c2wt	242	89	study	study	NN
cord-016300-vw11c2wt	242	90	Brain	Brain	NNP
cord-016300-vw11c2wt	242	91	natriuretic	natriuretic	JJ
cord-016300-vw11c2wt	242	92	peptide	peptide	NN
cord-016300-vw11c2wt	242	93	is	be	VBZ
cord-016300-vw11c2wt	242	94	a	a	DT
cord-016300-vw11c2wt	242	95	prognostic	prognostic	JJ
cord-016300-vw11c2wt	242	96	parameter	parameter	NN
cord-016300-vw11c2wt	242	97	in	in	IN
cord-016300-vw11c2wt	242	98	chronic	chronic	JJ
cord-016300-vw11c2wt	242	99	lung	lung	NN
cord-016300-vw11c2wt	242	100	disease	disease	NN
cord-016300-vw11c2wt	242	101	Higher	higher	RBR
cord-016300-vw11c2wt	242	102	urine	urine	NN
cord-016300-vw11c2wt	242	103	nitric	nitric	NN
cord-016300-vw11c2wt	242	104	oxide	oxide	NN
cord-016300-vw11c2wt	242	105	is	be	VBZ
cord-016300-vw11c2wt	242	106	associated	associate	VBN
cord-016300-vw11c2wt	242	107	with	with	IN
cord-016300-vw11c2wt	242	108	improved	improved	JJ
cord-016300-vw11c2wt	242	109	outcomes	outcome	NNS
cord-016300-vw11c2wt	242	110	in	in	IN
cord-016300-vw11c2wt	242	111	patients	patient	NNS
cord-016300-vw11c2wt	242	112	with	with	IN
cord-016300-vw11c2wt	242	113	acute	acute	JJ
cord-016300-vw11c2wt	242	114	lung	lung	NN
cord-016300-vw11c2wt	242	115	injury	injury	NN
cord-016300-vw11c2wt	242	116	Biomarkers	Biomarkers	NNPS
cord-016300-vw11c2wt	242	117	of	of	IN
cord-016300-vw11c2wt	242	118	inflammation	inflammation	NN
cord-016300-vw11c2wt	242	119	,	,	,
cord-016300-vw11c2wt	242	120	coagulation	coagulation	NN
cord-016300-vw11c2wt	242	121	and	and	CC
cord-016300-vw11c2wt	242	122	fibrinolysis	fibrinolysis	NN
cord-016300-vw11c2wt	242	123	predict	predict	VBP
cord-016300-vw11c2wt	242	124	mortality	mortality	NN
cord-016300-vw11c2wt	242	125	in	in	IN
cord-016300-vw11c2wt	242	126	acute	acute	JJ
cord-016300-vw11c2wt	242	127	lung	lung	NN
cord-016300-vw11c2wt	242	128	injury	injury	NN
cord-016300-vw11c2wt	242	129	Plasma	Plasma	NNP
cord-016300-vw11c2wt	242	130	fibrinogen	fibrinogen	NN
cord-016300-vw11c2wt	242	131	qualification	qualification	NN
cord-016300-vw11c2wt	242	132	as	as	IN
cord-016300-vw11c2wt	242	133	a	a	DT
cord-016300-vw11c2wt	242	134	drug	drug	NN
cord-016300-vw11c2wt	242	135	development	development	NN
cord-016300-vw11c2wt	242	136	tool	tool	NN
cord-016300-vw11c2wt	242	137	in	in	IN
cord-016300-vw11c2wt	242	138	chronic	chronic	JJ
cord-016300-vw11c2wt	242	139	obstructive	obstructive	JJ
cord-016300-vw11c2wt	242	140	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	242	141	disease	disease	NN
cord-016300-vw11c2wt	242	142	.	.	.
cord-016300-vw11c2wt	243	1	Perspective	perspective	NN
cord-016300-vw11c2wt	243	2	of	of	IN
cord-016300-vw11c2wt	243	3	the	the	DT
cord-016300-vw11c2wt	243	4	chronic	chronic	JJ
cord-016300-vw11c2wt	243	5	obstructive	obstructive	JJ
cord-016300-vw11c2wt	243	6	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	243	7	disease	disease	NN
cord-016300-vw11c2wt	243	8	biomarker	biomarker	NNP
cord-016300-vw11c2wt	243	9	qualification	qualification	NNP
cord-016300-vw11c2wt	243	10	consortium	consortium	NNP
cord-016300-vw11c2wt	243	11	Correlations	correlation	NNS
cord-016300-vw11c2wt	243	12	of	of	IN
cord-016300-vw11c2wt	243	13	salivary	salivary	JJ
cord-016300-vw11c2wt	243	14	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	243	15	with	with	IN
cord-016300-vw11c2wt	243	16	clinical	clinical	JJ
cord-016300-vw11c2wt	243	17	assessments	assessment	NNS
cord-016300-vw11c2wt	243	18	in	in	IN
cord-016300-vw11c2wt	243	19	patients	patient	NNS
cord-016300-vw11c2wt	243	20	with	with	IN
cord-016300-vw11c2wt	243	21	cystic	cystic	JJ
cord-016300-vw11c2wt	243	22	fibrosis	fibrosis	NN
cord-016300-vw11c2wt	243	23	Measurement	Measurement	NNP
cord-016300-vw11c2wt	243	24	of	of	IN
cord-016300-vw11c2wt	243	25	bronchial	bronchial	JJ
cord-016300-vw11c2wt	243	26	and	and	CC
cord-016300-vw11c2wt	243	27	alveolar	alveolar	JJ
cord-016300-vw11c2wt	243	28	nitric	nitric	NN
cord-016300-vw11c2wt	243	29	oxide	oxide	NN
cord-016300-vw11c2wt	243	30	production	production	NN
cord-016300-vw11c2wt	243	31	in	in	IN
cord-016300-vw11c2wt	243	32	normal	normal	JJ
cord-016300-vw11c2wt	243	33	children	child	NNS
cord-016300-vw11c2wt	243	34	and	and	CC
cord-016300-vw11c2wt	243	35	children	child	NNS
cord-016300-vw11c2wt	243	36	with	with	IN
cord-016300-vw11c2wt	243	37	asthma	asthma	NN
cord-016300-vw11c2wt	244	1	Parathyroid	parathyroid	JJ
cord-016300-vw11c2wt	244	2	hormone	hormone	NN
cord-016300-vw11c2wt	244	3	as	as	IN
cord-016300-vw11c2wt	244	4	a	a	DT
cord-016300-vw11c2wt	244	5	novel	novel	NN
cord-016300-vw11c2wt	244	6	biomarker	biomarker	NN
cord-016300-vw11c2wt	244	7	for	for	IN
cord-016300-vw11c2wt	244	8	chronic	chronic	JJ
cord-016300-vw11c2wt	244	9	obstructive	obstructive	JJ
cord-016300-vw11c2wt	244	10	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	244	11	disease	disease	NN
cord-016300-vw11c2wt	244	12	:	:	:
cord-016300-vw11c2wt	245	1	Korean	Korean	NNP
cord-016300-vw11c2wt	245	2	National	National	NNP
cord-016300-vw11c2wt	245	3	Health	Health	NNP
cord-016300-vw11c2wt	245	4	and	and	CC
cord-016300-vw11c2wt	245	5	Nutrition	Nutrition	NNP
cord-016300-vw11c2wt	245	6	Examination	Examination	NNP
cord-016300-vw11c2wt	245	7	Survey	Survey	NNP
cord-016300-vw11c2wt	245	8	High	high	JJ
cord-016300-vw11c2wt	245	9	serum	serum	NN
cord-016300-vw11c2wt	245	10	levels	level	NNS
cord-016300-vw11c2wt	245	11	of	of	IN
cord-016300-vw11c2wt	245	12	tumour	tumour	NN
cord-016300-vw11c2wt	245	13	necrosis	necrosis	NN
cord-016300-vw11c2wt	245	14	factor	factor	NN
cord-016300-vw11c2wt	245	15	-	-	HYPH
cord-016300-vw11c2wt	245	16	α	α	NN
cord-016300-vw11c2wt	245	17	and	and	CC
cord-016300-vw11c2wt	245	18	interleukin-8	interleukin-8	NNP
cord-016300-vw11c2wt	245	19	in	in	IN
cord-016300-vw11c2wt	245	20	severe	severe	JJ
cord-016300-vw11c2wt	245	21	asthma	asthma	NN
cord-016300-vw11c2wt	245	22	:	:	:
cord-016300-vw11c2wt	245	23	markers	marker	NNS
cord-016300-vw11c2wt	245	24	of	of	IN
cord-016300-vw11c2wt	245	25	systemic	systemic	JJ
cord-016300-vw11c2wt	245	26	inflammation	inflammation	NN
cord-016300-vw11c2wt	245	27	?	?	.
cord-016300-vw11c2wt	246	1	The	the	DT
cord-016300-vw11c2wt	246	2	role	role	NN
cord-016300-vw11c2wt	246	3	of	of	IN
cord-016300-vw11c2wt	246	4	exhaled	exhale	VBN
cord-016300-vw11c2wt	246	5	nitric	nitric	JJ
cord-016300-vw11c2wt	246	6	oxide	oxide	NN
cord-016300-vw11c2wt	246	7	and	and	CC
cord-016300-vw11c2wt	246	8	exhaled	exhale	VBD
cord-016300-vw11c2wt	246	9	breath	breath	NN
cord-016300-vw11c2wt	246	10	condensates	condensate	NNS
cord-016300-vw11c2wt	246	11	in	in	IN
cord-016300-vw11c2wt	246	12	evaluating	evaluate	VBG
cord-016300-vw11c2wt	246	13	airway	airway	NN
cord-016300-vw11c2wt	246	14	inflammation	inflammation	NN
cord-016300-vw11c2wt	246	15	in	in	IN
cord-016300-vw11c2wt	246	16	asthma	asthma	NN
cord-016300-vw11c2wt	246	17	Increased	increase	VBN
cord-016300-vw11c2wt	246	18	serum	serum	NN
cord-016300-vw11c2wt	246	19	levels	level	NNS
cord-016300-vw11c2wt	246	20	of	of	IN
cord-016300-vw11c2wt	246	21	chromogranin	chromogranin	NNS
cord-016300-vw11c2wt	246	22	A	a	NN
cord-016300-vw11c2wt	246	23	in	in	IN
cord-016300-vw11c2wt	246	24	male	male	JJ
cord-016300-vw11c2wt	246	25	smokers	smoker	NNS
cord-016300-vw11c2wt	246	26	with	with	IN
cord-016300-vw11c2wt	246	27	airway	airway	JJ
cord-016300-vw11c2wt	246	28	obstruction	obstruction	NN
cord-016300-vw11c2wt	246	29	Systemic	systemic	JJ
cord-016300-vw11c2wt	246	30	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	246	31	of	of	IN
cord-016300-vw11c2wt	246	32	collagen	collagen	NN
cord-016300-vw11c2wt	246	33	and	and	CC
cord-016300-vw11c2wt	246	34	elastin	elastin	NN
cord-016300-vw11c2wt	246	35	turnover	turnover	NN
cord-016300-vw11c2wt	246	36	are	be	VBP
cord-016300-vw11c2wt	246	37	associated	associate	VBN
cord-016300-vw11c2wt	246	38	with	with	IN
cord-016300-vw11c2wt	246	39	clinically	clinically	RB
cord-016300-vw11c2wt	246	40	relevant	relevant	JJ
cord-016300-vw11c2wt	246	41	outcomes	outcome	NNS
cord-016300-vw11c2wt	246	42	in	in	IN
cord-016300-vw11c2wt	246	43	COPD	COPD	NNP
cord-016300-vw11c2wt	246	44	Pulmonary	Pulmonary	NNP
cord-016300-vw11c2wt	246	45	surfactant	surfactant	NN
cord-016300-vw11c2wt	246	46	proteins	protein	VBZ
cord-016300-vw11c2wt	246	47	A	a	VBP
cord-016300-vw11c2wt	246	48	and	and	CC
cord-016300-vw11c2wt	246	49	D	d	NN
cord-016300-vw11c2wt	246	50	:	:	:
cord-016300-vw11c2wt	246	51	innate	innate	JJ
cord-016300-vw11c2wt	246	52	immune	immune	JJ
cord-016300-vw11c2wt	246	53	functions	function	NNS
cord-016300-vw11c2wt	246	54	and	and	CC
cord-016300-vw11c2wt	246	55	biomarkers	biomarker	NNS
cord-016300-vw11c2wt	246	56	for	for	IN
cord-016300-vw11c2wt	246	57	lung	lung	NN
cord-016300-vw11c2wt	246	58	diseases	disease	NNS
cord-016300-vw11c2wt	247	1	IFN	IFN	NNP
cord-016300-vw11c2wt	247	2	-	-	HYPH
cord-016300-vw11c2wt	247	3	gamma	gamma	NN
cord-016300-vw11c2wt	247	4	-	-	HYPH
cord-016300-vw11c2wt	247	5	induced	induce	VBN
cord-016300-vw11c2wt	247	6	protein	protein	NN
cord-016300-vw11c2wt	247	7	10	10	CD
cord-016300-vw11c2wt	247	8	is	be	VBZ
cord-016300-vw11c2wt	247	9	a	a	DT
cord-016300-vw11c2wt	247	10	novel	novel	JJ
cord-016300-vw11c2wt	247	11	biomarker	biomarker	NN
cord-016300-vw11c2wt	247	12	of	of	IN
cord-016300-vw11c2wt	247	13	rhinovirus	rhinovirus	NN
cord-016300-vw11c2wt	247	14	-	-	HYPH
cord-016300-vw11c2wt	247	15	induced	induce	VBN
cord-016300-vw11c2wt	247	16	asthma	asthma	NN
cord-016300-vw11c2wt	247	17	exacerbations	exacerbation	NNS
cord-016300-vw11c2wt	247	18	Hyperuricemia	Hyperuricemia	NNP
cord-016300-vw11c2wt	248	1	is	be	VBZ
cord-016300-vw11c2wt	248	2	a	a	DT
cord-016300-vw11c2wt	248	3	biomarker	biomarker	NN
cord-016300-vw11c2wt	248	4	of	of	IN
cord-016300-vw11c2wt	248	5	early	early	JJ
cord-016300-vw11c2wt	248	6	mortality	mortality	NN
cord-016300-vw11c2wt	248	7	in	in	IN
cord-016300-vw11c2wt	248	8	patients	patient	NNS
cord-016300-vw11c2wt	248	9	with	with	IN
cord-016300-vw11c2wt	248	10	chronic	chronic	JJ
cord-016300-vw11c2wt	248	11	obstructive	obstructive	JJ
cord-016300-vw11c2wt	248	12	pulmonary	pulmonary	JJ
cord-016300-vw11c2wt	248	13	disease	disease	NN
cord-016300-vw11c2wt	248	14	Endothelin-1	Endothelin-1	NNP
cord-016300-vw11c2wt	248	15	in	in	IN
cord-016300-vw11c2wt	248	16	exhaled	exhale	VBN
cord-016300-vw11c2wt	248	17	breath	breath	NN
cord-016300-vw11c2wt	248	18	condensate	condensate	NN
cord-016300-vw11c2wt	248	19	of	of	IN
cord-016300-vw11c2wt	248	20	stable	stable	JJ
cord-016300-vw11c2wt	248	21	and	and	CC
cord-016300-vw11c2wt	248	22	unstable	unstable	JJ
cord-016300-vw11c2wt	248	23	asthma	asthma	NN
cord-016300-vw11c2wt	248	24	patients	patient	NNS