id sid tid token lemma pos cord-015306-us58wwmp 1 1 key key JJ cord-015306-us58wwmp 1 2 : : : cord-015306-us58wwmp 1 3 cord-015306-us58wwmp cord-015306-us58wwmp NNP cord-015306-us58wwmp 1 4 authors author NNS cord-015306-us58wwmp 1 5 : : : cord-015306-us58wwmp 2 1 nan nan NNP cord-015306-us58wwmp 2 2 title title NN cord-015306-us58wwmp 2 3 : : : cord-015306-us58wwmp 2 4 Abstracts abstract NNS cord-015306-us58wwmp 2 5 for for IN cord-015306-us58wwmp 2 6 the the DT cord-015306-us58wwmp 2 7 IPNA IPNA NNP cord-015306-us58wwmp 2 8 Congress Congress NNP cord-015306-us58wwmp 2 9 , , , cord-015306-us58wwmp 2 10 30 30 CD cord-015306-us58wwmp 2 11 August August NNP cord-015306-us58wwmp 2 12 - - HYPH cord-015306-us58wwmp 2 13 3 3 CD cord-015306-us58wwmp 2 14 September September NNP cord-015306-us58wwmp 2 15 2013 2013 CD cord-015306-us58wwmp 2 16 , , , cord-015306-us58wwmp 2 17 Shanghai Shanghai NNP cord-015306-us58wwmp 2 18 , , , cord-015306-us58wwmp 2 19 China China NNP cord-015306-us58wwmp 2 20 date date NN cord-015306-us58wwmp 2 21 : : : cord-015306-us58wwmp 2 22 2013 2013 CD cord-015306-us58wwmp 2 23 - - SYM cord-015306-us58wwmp 2 24 06 06 CD cord-015306-us58wwmp 2 25 - - SYM cord-015306-us58wwmp 2 26 21 21 CD cord-015306-us58wwmp 2 27 journal journal NN cord-015306-us58wwmp 2 28 : : : cord-015306-us58wwmp 2 29 Pediatr Pediatr NNP cord-015306-us58wwmp 2 30 Nephrol Nephrol NNP cord-015306-us58wwmp 2 31 DOI DOI NNP cord-015306-us58wwmp 2 32 : : : cord-015306-us58wwmp 2 33 10.1007 10.1007 CD cord-015306-us58wwmp 2 34 / / SYM cord-015306-us58wwmp 2 35 s00467 s00467 NNP cord-015306-us58wwmp 2 36 - - HYPH cord-015306-us58wwmp 2 37 013 013 CD cord-015306-us58wwmp 2 38 - - HYPH cord-015306-us58wwmp 2 39 2518 2518 CD cord-015306-us58wwmp 2 40 - - SYM cord-015306-us58wwmp 2 41 4 4 CD cord-015306-us58wwmp 2 42 sha sha NNP cord-015306-us58wwmp 2 43 : : : cord-015306-us58wwmp 2 44 1379bd26225585c1db5d1b25d1809d60357a9017 1379bd26225585c1db5d1b25d1809d60357a9017 CD cord-015306-us58wwmp 2 45 doc_id doc_id CD cord-015306-us58wwmp 2 46 : : : cord-015306-us58wwmp 2 47 15306 15306 CD cord-015306-us58wwmp 2 48 cord_uid cord_uid NNS cord-015306-us58wwmp 2 49 : : : cord-015306-us58wwmp 2 50 us58wwmp us58wwmp NNP cord-015306-us58wwmp 2 51 nan nan NNP cord-015306-us58wwmp 3 1 first first JJ cord-015306-us58wwmp 3 2 5 5 CD cord-015306-us58wwmp 3 3 days day NNS cord-015306-us58wwmp 3 4 after after IN cord-015306-us58wwmp 3 5 the the DT cord-015306-us58wwmp 3 6 diagnosis diagnosis NN cord-015306-us58wwmp 3 7 . . . cord-015306-us58wwmp 4 1 DWI DWI NNP cord-015306-us58wwmp 4 2 - - HYPH cord-015306-us58wwmp 4 3 MRI MRI NNP cord-015306-us58wwmp 4 4 was be VBD cord-015306-us58wwmp 4 5 performed perform VBN cord-015306-us58wwmp 4 6 without without IN cord-015306-us58wwmp 4 7 application application NN cord-015306-us58wwmp 4 8 of of IN cord-015306-us58wwmp 4 9 contrast contrast NN cord-015306-us58wwmp 4 10 medium medium NN cord-015306-us58wwmp 4 11 and and CC cord-015306-us58wwmp 4 12 without without IN cord-015306-us58wwmp 4 13 general general JJ cord-015306-us58wwmp 4 14 anaesthesia anaesthesia NN cord-015306-us58wwmp 4 15 . . . cord-015306-us58wwmp 5 1 Results result NNS cord-015306-us58wwmp 5 2 : : : cord-015306-us58wwmp 6 1 DWI DWI NNP cord-015306-us58wwmp 6 2 - - HYPH cord-015306-us58wwmp 6 3 MRI MRI NNP cord-015306-us58wwmp 6 4 examination examination NN cord-015306-us58wwmp 6 5 confirmed confirm VBD cord-015306-us58wwmp 6 6 the the DT cord-015306-us58wwmp 6 7 inflammatory inflammatory JJ cord-015306-us58wwmp 6 8 infiltration infiltration NN cord-015306-us58wwmp 6 9 in in IN cord-015306-us58wwmp 6 10 kidney kidney NN cord-015306-us58wwmp 6 11 parenchyma parenchyma NNS cord-015306-us58wwmp 6 12 in in IN cord-015306-us58wwmp 6 13 all all DT cord-015306-us58wwmp 6 14 our -PRON- PRP$ cord-015306-us58wwmp 6 15 patients patient NNS cord-015306-us58wwmp 6 16 ( ( -LRB- cord-015306-us58wwmp 6 17 100 100 CD cord-015306-us58wwmp 6 18 % % NN cord-015306-us58wwmp 6 19 ) ) -RRB- cord-015306-us58wwmp 6 20 . . . cord-015306-us58wwmp 7 1 On on IN cord-015306-us58wwmp 7 2 the the DT cord-015306-us58wwmp 7 3 other other JJ cord-015306-us58wwmp 7 4 hand hand NN cord-015306-us58wwmp 7 5 , , , cord-015306-us58wwmp 7 6 static static JJ cord-015306-us58wwmp 7 7 renal renal JJ cord-015306-us58wwmp 7 8 scintigraphy scintigraphy NN cord-015306-us58wwmp 7 9 confirmed confirm VBD cord-015306-us58wwmp 7 10 inflammation inflammation NN cord-015306-us58wwmp 7 11 only only RB cord-015306-us58wwmp 7 12 in in IN cord-015306-us58wwmp 7 13 15 15 CD cord-015306-us58wwmp 7 14 children child NNS cord-015306-us58wwmp 7 15 ( ( -LRB- cord-015306-us58wwmp 7 16 60 60 CD cord-015306-us58wwmp 7 17 % % NN cord-015306-us58wwmp 7 18 ) ) -RRB- cord-015306-us58wwmp 7 19 . . . cord-015306-us58wwmp 8 1 Six six CD cord-015306-us58wwmp 8 2 months month NNS cord-015306-us58wwmp 8 3 later later RB cord-015306-us58wwmp 8 4 , , , cord-015306-us58wwmp 8 5 none none NN cord-015306-us58wwmp 8 6 of of IN cord-015306-us58wwmp 8 7 the the DT cord-015306-us58wwmp 8 8 two two CD cord-015306-us58wwmp 8 9 follow follow VB cord-015306-us58wwmp 8 10 - - HYPH cord-015306-us58wwmp 8 11 up up RP cord-015306-us58wwmp 8 12 examinations examination NNS cord-015306-us58wwmp 8 13 showed show VBD cord-015306-us58wwmp 8 14 any any DT cord-015306-us58wwmp 8 15 signs sign NNS cord-015306-us58wwmp 8 16 of of IN cord-015306-us58wwmp 8 17 inflammation inflammation NN cord-015306-us58wwmp 8 18 or or CC cord-015306-us58wwmp 8 19 scarring scarring NN cord-015306-us58wwmp 8 20 in in IN cord-015306-us58wwmp 8 21 17 17 CD cord-015306-us58wwmp 8 22 children child NNS cord-015306-us58wwmp 8 23 examined examine VBN cord-015306-us58wwmp 8 24 so so RB cord-015306-us58wwmp 8 25 far far RB cord-015306-us58wwmp 8 26 . . . cord-015306-us58wwmp 9 1 Conclusion conclusion NN cord-015306-us58wwmp 9 2 : : : cord-015306-us58wwmp 10 1 In in IN cord-015306-us58wwmp 10 2 conclusion conclusion NN cord-015306-us58wwmp 10 3 , , , cord-015306-us58wwmp 10 4 nuclear nuclear JJ cord-015306-us58wwmp 10 5 magnetic magnetic JJ cord-015306-us58wwmp 10 6 resonance resonance NN cord-015306-us58wwmp 10 7 ( ( -LRB- cord-015306-us58wwmp 10 8 DWI DWI NNP cord-015306-us58wwmp 10 9 - - HYPH cord-015306-us58wwmp 10 10 MRI MRI NNP cord-015306-us58wwmp 10 11 ) ) -RRB- cord-015306-us58wwmp 10 12 imaging imaging NN cord-015306-us58wwmp 10 13 seems seem VBZ cord-015306-us58wwmp 10 14 more more RBR cord-015306-us58wwmp 10 15 beneficial beneficial JJ cord-015306-us58wwmp 10 16 and and CC cord-015306-us58wwmp 10 17 accurate accurate JJ cord-015306-us58wwmp 10 18 in in IN cord-015306-us58wwmp 10 19 the the DT cord-015306-us58wwmp 10 20 diagnostics diagnostic NNS cord-015306-us58wwmp 10 21 of of IN cord-015306-us58wwmp 10 22 acute acute JJ cord-015306-us58wwmp 10 23 pyelonephritis pyelonephritis NN cord-015306-us58wwmp 10 24 when when WRB cord-015306-us58wwmp 10 25 compared compare VBN cord-015306-us58wwmp 10 26 with with IN cord-015306-us58wwmp 10 27 static static JJ cord-015306-us58wwmp 10 28 renal renal JJ cord-015306-us58wwmp 10 29 scintigraphy scintigraphy NN cord-015306-us58wwmp 10 30 . . . cord-015306-us58wwmp 11 1 Moreover moreover RB cord-015306-us58wwmp 11 2 , , , cord-015306-us58wwmp 11 3 DWI DWI NNP cord-015306-us58wwmp 11 4 - - HYPH cord-015306-us58wwmp 11 5 MRI MRI NNP cord-015306-us58wwmp 11 6 provides provide VBZ cord-015306-us58wwmp 11 7 more more RBR cord-015306-us58wwmp 11 8 accurate accurate JJ cord-015306-us58wwmp 11 9 information information NN cord-015306-us58wwmp 11 10 on on IN cord-015306-us58wwmp 11 11 the the DT cord-015306-us58wwmp 11 12 extent extent NN cord-015306-us58wwmp 11 13 of of IN cord-015306-us58wwmp 11 14 kidney kidney NN cord-015306-us58wwmp 11 15 damage damage NN cord-015306-us58wwmp 11 16 . . . cord-015306-us58wwmp 12 1 Objective objective NN cord-015306-us58wwmp 12 2 : : : cord-015306-us58wwmp 13 1 To to TO cord-015306-us58wwmp 13 2 evaluate evaluate VB cord-015306-us58wwmp 13 3 the the DT cord-015306-us58wwmp 13 4 most most RBS cord-015306-us58wwmp 13 5 proper proper JJ cord-015306-us58wwmp 13 6 radiologic radiologic JJ cord-015306-us58wwmp 13 7 investigation investigation NN cord-015306-us58wwmp 13 8 algorithm algorithm NN cord-015306-us58wwmp 13 9 in in IN cord-015306-us58wwmp 13 10 detecting detect VBG cord-015306-us58wwmp 13 11 high high JJ cord-015306-us58wwmp 13 12 grade grade NN cord-015306-us58wwmp 13 13 vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 13 14 reflux reflux NN cord-015306-us58wwmp 13 15 ( ( -LRB- cord-015306-us58wwmp 13 16 VUR VUR NNP cord-015306-us58wwmp 13 17 ) ) -RRB- cord-015306-us58wwmp 13 18 and and CC cord-015306-us58wwmp 13 19 renal renal JJ cord-015306-us58wwmp 13 20 cortical cortical JJ cord-015306-us58wwmp 13 21 scarring scarring NN cord-015306-us58wwmp 13 22 after after IN cord-015306-us58wwmp 13 23 first first JJ cord-015306-us58wwmp 13 24 febrile febrile JJ cord-015306-us58wwmp 13 25 urinary urinary JJ cord-015306-us58wwmp 13 26 tract tract JJ cord-015306-us58wwmp 13 27 infections infection NNS cord-015306-us58wwmp 13 28 in in IN cord-015306-us58wwmp 13 29 infants infant NNS cord-015306-us58wwmp 13 30 aged age VBN cord-015306-us58wwmp 13 31 less less JJR cord-015306-us58wwmp 13 32 than than IN cord-015306-us58wwmp 13 33 one one CD cord-015306-us58wwmp 13 34 year year NN cord-015306-us58wwmp 13 35 . . . cord-015306-us58wwmp 14 1 Methods method NNS cord-015306-us58wwmp 14 2 : : : cord-015306-us58wwmp 14 3 A a DT cord-015306-us58wwmp 14 4 total total NN cord-015306-us58wwmp 14 5 of of IN cord-015306-us58wwmp 14 6 408 408 CD cord-015306-us58wwmp 14 7 infants infant NNS cord-015306-us58wwmp 14 8 aged age VBN cord-015306-us58wwmp 14 9 less less JJR cord-015306-us58wwmp 14 10 than than IN cord-015306-us58wwmp 14 11 one one CD cord-015306-us58wwmp 14 12 year year NN cord-015306-us58wwmp 14 13 with with IN cord-015306-us58wwmp 14 14 a a DT cord-015306-us58wwmp 14 15 first first JJ cord-015306-us58wwmp 14 16 febrile febrile JJ cord-015306-us58wwmp 14 17 urinary urinary JJ cord-015306-us58wwmp 14 18 tract tract NN cord-015306-us58wwmp 14 19 infection infection NN cord-015306-us58wwmp 14 20 who who WP cord-015306-us58wwmp 14 21 completed complete VBD cord-015306-us58wwmp 14 22 the the DT cord-015306-us58wwmp 14 23 diagnostic diagnostic JJ cord-015306-us58wwmp 14 24 follow follow NN cord-015306-us58wwmp 14 25 up up IN cord-015306-us58wwmp 14 26 of of IN cord-015306-us58wwmp 14 27 renal renal JJ cord-015306-us58wwmp 14 28 bladder bladder NN cord-015306-us58wwmp 14 29 ultrasound ultrasound NN cord-015306-us58wwmp 14 30 ( ( -LRB- cord-015306-us58wwmp 14 31 RBUS RBUS NNP cord-015306-us58wwmp 14 32 ) ) -RRB- cord-015306-us58wwmp 14 33 , , , cord-015306-us58wwmp 14 34 voiding void VBG cord-015306-us58wwmp 14 35 cystourethrography cystourethrography NNP cord-015306-us58wwmp 14 36 ( ( -LRB- cord-015306-us58wwmp 14 37 VCUG VCUG NNP cord-015306-us58wwmp 14 38 ) ) -RRB- cord-015306-us58wwmp 14 39 and and CC cord-015306-us58wwmp 14 40 late late JJ cord-015306-us58wwmp 14 41 6 6 CD cord-015306-us58wwmp 14 42 months month NNS cord-015306-us58wwmp 14 43 technetium technetium NNP cord-015306-us58wwmp 14 44 99 99 CD cord-015306-us58wwmp 14 45 dimercaptosuccinic dimercaptosuccinic JJ cord-015306-us58wwmp 14 46 acid acid NN cord-015306-us58wwmp 14 47 renal renal JJ cord-015306-us58wwmp 14 48 scan scan NN cord-015306-us58wwmp 14 49 ( ( -LRB- cord-015306-us58wwmp 14 50 DMSA DMSA NNP cord-015306-us58wwmp 14 51 ) ) -RRB- cord-015306-us58wwmp 14 52 were be VBD cord-015306-us58wwmp 14 53 enrolled enrol VBN cord-015306-us58wwmp 14 54 in in IN cord-015306-us58wwmp 14 55 the the DT cord-015306-us58wwmp 14 56 study study NN cord-015306-us58wwmp 14 57 . . . cord-015306-us58wwmp 15 1 The the DT cord-015306-us58wwmp 15 2 most most RBS cord-015306-us58wwmp 15 3 proper proper JJ cord-015306-us58wwmp 15 4 radiologic radiologic JJ cord-015306-us58wwmp 15 5 investigation investigation NN cord-015306-us58wwmp 15 6 algorithm algorithm NN cord-015306-us58wwmp 15 7 that that WDT cord-015306-us58wwmp 15 8 could could MD cord-015306-us58wwmp 15 9 highly highly RB cord-015306-us58wwmp 15 10 detected detect VBN cord-015306-us58wwmp 15 11 both both CC cord-015306-us58wwmp 15 12 high high JJ cord-015306-us58wwmp 15 13 grade grade NN cord-015306-us58wwmp 15 14 vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 15 15 reflux reflux NN cord-015306-us58wwmp 15 16 and and CC cord-015306-us58wwmp 15 17 renal renal JJ cord-015306-us58wwmp 15 18 scar scar NN cord-015306-us58wwmp 15 19 in in IN cord-015306-us58wwmp 15 20 infants infant NNS cord-015306-us58wwmp 15 21 after after IN cord-015306-us58wwmp 15 22 the the DT cord-015306-us58wwmp 15 23 first first JJ cord-015306-us58wwmp 15 24 febrile febrile JJ cord-015306-us58wwmp 15 25 urinary urinary JJ cord-015306-us58wwmp 15 26 tract tract NN cord-015306-us58wwmp 15 27 infection infection NN cord-015306-us58wwmp 15 28 considering consider VBG cord-015306-us58wwmp 15 29 high high JJ cord-015306-us58wwmp 15 30 benefit benefit NN cord-015306-us58wwmp 15 31 , , , cord-015306-us58wwmp 15 32 low low JJ cord-015306-us58wwmp 15 33 cost cost NN cord-015306-us58wwmp 15 34 , , , cord-015306-us58wwmp 15 35 low low JJ cord-015306-us58wwmp 15 36 radiation radiation NN cord-015306-us58wwmp 15 37 exposure exposure NN cord-015306-us58wwmp 15 38 were be VBD cord-015306-us58wwmp 15 39 assessed assess VBN cord-015306-us58wwmp 15 40 . . . cord-015306-us58wwmp 16 1 Results result NNS cord-015306-us58wwmp 16 2 : : : cord-015306-us58wwmp 17 1 Abnormal abnormal JJ cord-015306-us58wwmp 17 2 renal renal JJ cord-015306-us58wwmp 17 3 bladder bladder NN cord-015306-us58wwmp 17 4 ultrasound ultrasound NN cord-015306-us58wwmp 17 5 ( ( -LRB- cord-015306-us58wwmp 17 6 RBUS RBUS NNP cord-015306-us58wwmp 17 7 ) ) -RRB- cord-015306-us58wwmp 17 8 was be VBD cord-015306-us58wwmp 17 9 identified identify VBN cord-015306-us58wwmp 17 10 in in IN cord-015306-us58wwmp 17 11 101 101 CD cord-015306-us58wwmp 17 12 ( ( -LRB- cord-015306-us58wwmp 17 13 24.7 24.7 CD cord-015306-us58wwmp 17 14 % % NN cord-015306-us58wwmp 17 15 ) ) -RRB- cord-015306-us58wwmp 17 16 infants infant NNS cord-015306-us58wwmp 17 17 . . . cord-015306-us58wwmp 18 1 Vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 18 2 reflux reflux NN cord-015306-us58wwmp 18 3 ( ( -LRB- cord-015306-us58wwmp 18 4 VCUG VCUG NNP cord-015306-us58wwmp 18 5 ) ) -RRB- cord-015306-us58wwmp 18 6 was be VBD cord-015306-us58wwmp 18 7 identified identify VBN cord-015306-us58wwmp 18 8 in in IN cord-015306-us58wwmp 18 9 92 92 CD cord-015306-us58wwmp 18 10 ( ( -LRB- cord-015306-us58wwmp 18 11 22.5 22.5 CD cord-015306-us58wwmp 18 12 % % NN cord-015306-us58wwmp 18 13 ) ) -RRB- cord-015306-us58wwmp 18 14 with with IN cord-015306-us58wwmp 18 15 high high JJ cord-015306-us58wwmp 18 16 grade grade NN cord-015306-us58wwmp 18 17 reflux reflux NN cord-015306-us58wwmp 18 18 ( ( -LRB- cord-015306-us58wwmp 18 19 grade grade NN cord-015306-us58wwmp 18 20 4 4 CD cord-015306-us58wwmp 18 21 and and CC cord-015306-us58wwmp 18 22 5 5 CD cord-015306-us58wwmp 18 23 ) ) -RRB- cord-015306-us58wwmp 18 24 in in IN cord-015306-us58wwmp 18 25 18 18 CD cord-015306-us58wwmp 18 26 ( ( -LRB- cord-015306-us58wwmp 18 27 4.4 4.4 CD cord-015306-us58wwmp 18 28 % % NN cord-015306-us58wwmp 18 29 ) ) -RRB- cord-015306-us58wwmp 18 30 infants infant NNS cord-015306-us58wwmp 18 31 . . . cord-015306-us58wwmp 19 1 Abnormal abnormal JJ cord-015306-us58wwmp 19 2 renal renal JJ cord-015306-us58wwmp 19 3 parenchyma parenchyma NNS cord-015306-us58wwmp 19 4 including include VBG cord-015306-us58wwmp 19 5 renal renal JJ cord-015306-us58wwmp 19 6 scar scar NN cord-015306-us58wwmp 19 7 was be VBD cord-015306-us58wwmp 19 8 identified identify VBN cord-015306-us58wwmp 19 9 in in IN cord-015306-us58wwmp 19 10 32 32 CD cord-015306-us58wwmp 19 11 ( ( -LRB- cord-015306-us58wwmp 19 12 7.8 7.8 CD cord-015306-us58wwmp 19 13 % % NN cord-015306-us58wwmp 19 14 ) ) -RRB- cord-015306-us58wwmp 19 15 infants infant NNS cord-015306-us58wwmp 19 16 . . . cord-015306-us58wwmp 20 1 The the DT cord-015306-us58wwmp 20 2 top top JJ cord-015306-us58wwmp 20 3 down down JJ cord-015306-us58wwmp 20 4 approach approach NN cord-015306-us58wwmp 20 5 with with IN cord-015306-us58wwmp 20 6 late late JJ cord-015306-us58wwmp 20 7 6 6 CD cord-015306-us58wwmp 20 8 months month NNS cord-015306-us58wwmp 21 1 DMSA DMSA NNP cord-015306-us58wwmp 21 2 scan scan NNP cord-015306-us58wwmp 21 3 showed show VBD cord-015306-us58wwmp 21 4 high high JJ cord-015306-us58wwmp 21 5 benefit benefit NN cord-015306-us58wwmp 21 6 in in IN cord-015306-us58wwmp 21 7 detecting detect VBG cord-015306-us58wwmp 21 8 all all DT cord-015306-us58wwmp 21 9 abnormal abnormal JJ cord-015306-us58wwmp 21 10 renal renal JJ cord-015306-us58wwmp 21 11 parenchyma parenchyma NNS cord-015306-us58wwmp 21 12 including include VBG cord-015306-us58wwmp 21 13 renal renal JJ cord-015306-us58wwmp 21 14 scars scar NNS cord-015306-us58wwmp 21 15 , , , cord-015306-us58wwmp 21 16 with with IN cord-015306-us58wwmp 21 17 high high JJ cord-015306-us58wwmp 21 18 sensitivity sensitivity NN cord-015306-us58wwmp 21 19 ( ( -LRB- cord-015306-us58wwmp 21 20 72 72 CD cord-015306-us58wwmp 21 21 % % NN cord-015306-us58wwmp 21 22 ) ) -RRB- cord-015306-us58wwmp 21 23 in in IN cord-015306-us58wwmp 21 24 detecting detect VBG cord-015306-us58wwmp 21 25 high high JJ cord-015306-us58wwmp 21 26 grade grade NN cord-015306-us58wwmp 21 27 vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 21 28 reflux reflux NN cord-015306-us58wwmp 21 29 ( ( -LRB- cord-015306-us58wwmp 21 30 VUR VUR NNP cord-015306-us58wwmp 21 31 ) ) -RRB- cord-015306-us58wwmp 21 32 whereas whereas IN cord-015306-us58wwmp 21 33 reducing reduce VBG cord-015306-us58wwmp 21 34 the the DT cord-015306-us58wwmp 21 35 unnecessary unnecessary JJ cord-015306-us58wwmp 21 36 investigation investigation NN cord-015306-us58wwmp 21 37 for for IN cord-015306-us58wwmp 21 38 low low JJ cord-015306-us58wwmp 21 39 grade grade NN cord-015306-us58wwmp 21 40 VUR VUR NNP cord-015306-us58wwmp 21 41 ( ( -LRB- cord-015306-us58wwmp 21 42 94.6 94.6 CD cord-015306-us58wwmp 21 43 % % NN cord-015306-us58wwmp 21 44 ) ) -RRB- cord-015306-us58wwmp 21 45 and and CC cord-015306-us58wwmp 21 46 radiation radiation NN cord-015306-us58wwmp 21 47 exposure exposure NN cord-015306-us58wwmp 21 48 per per IN cord-015306-us58wwmp 21 49 patient patient NN cord-015306-us58wwmp 21 50 ( ( -LRB- cord-015306-us58wwmp 21 51 0.89 0.89 CD cord-015306-us58wwmp 21 52 mSv mSv NNP cord-015306-us58wwmp 21 53 ) ) -RRB- cord-015306-us58wwmp 21 54 . . . cord-015306-us58wwmp 22 1 Conclusion conclusion NN cord-015306-us58wwmp 22 2 : : : cord-015306-us58wwmp 22 3 Currently currently RB cord-015306-us58wwmp 22 4 , , , cord-015306-us58wwmp 22 5 there there EX cord-015306-us58wwmp 22 6 is be VBZ cord-015306-us58wwmp 22 7 no no DT cord-015306-us58wwmp 22 8 ideal ideal JJ cord-015306-us58wwmp 22 9 diagnostic diagnostic JJ cord-015306-us58wwmp 22 10 radiologic radiologic JJ cord-015306-us58wwmp 22 11 investigation investigation NN cord-015306-us58wwmp 22 12 after after IN cord-015306-us58wwmp 22 13 a a DT cord-015306-us58wwmp 22 14 first first JJ cord-015306-us58wwmp 22 15 febrile febrile JJ cord-015306-us58wwmp 22 16 urinary urinary JJ cord-015306-us58wwmp 22 17 tract tract NN cord-015306-us58wwmp 22 18 infection infection NN cord-015306-us58wwmp 22 19 in in IN cord-015306-us58wwmp 22 20 infants infant NNS cord-015306-us58wwmp 22 21 and and CC cord-015306-us58wwmp 22 22 children child NNS cord-015306-us58wwmp 22 23 . . . cord-015306-us58wwmp 23 1 The the DT cord-015306-us58wwmp 23 2 study study NN cord-015306-us58wwmp 23 3 suggest suggest VBP cord-015306-us58wwmp 23 4 performing perform VBG cord-015306-us58wwmp 23 5 the the DT cord-015306-us58wwmp 23 6 top top JJ cord-015306-us58wwmp 23 7 down down JJ cord-015306-us58wwmp 23 8 approach approach NN cord-015306-us58wwmp 23 9 with with IN cord-015306-us58wwmp 23 10 late late JJ cord-015306-us58wwmp 23 11 6 6 CD cord-015306-us58wwmp 23 12 months month NNS cord-015306-us58wwmp 23 13 DMSA DMSA NNS cord-015306-us58wwmp 23 14 scan scan VBP cord-015306-us58wwmp 23 15 that that WDT cord-015306-us58wwmp 23 16 could could MD cord-015306-us58wwmp 23 17 detect detect VB cord-015306-us58wwmp 23 18 all all DT cord-015306-us58wwmp 23 19 renal renal JJ cord-015306-us58wwmp 23 20 scars scar NNS cord-015306-us58wwmp 23 21 and and CC cord-015306-us58wwmp 23 22 highly highly JJ cord-015306-us58wwmp 23 23 detection detection NN cord-015306-us58wwmp 23 24 of of IN cord-015306-us58wwmp 23 25 high high JJ cord-015306-us58wwmp 23 26 grade grade NN cord-015306-us58wwmp 23 27 VUR VUR NNP cord-015306-us58wwmp 23 28 . . . cord-015306-us58wwmp 24 1 Abstract abstract JJ cord-015306-us58wwmp 24 2 # # NN cord-015306-us58wwmp 24 3 P p NN cord-015306-us58wwmp 24 4 - - HYPH cord-015306-us58wwmp 24 5 SAT010 SAT010 NNP cord-015306-us58wwmp 24 6 Association Association NNP cord-015306-us58wwmp 24 7 between between IN cord-015306-us58wwmp 24 8 postvoid postvoid JJ cord-015306-us58wwmp 24 9 urine urine NN cord-015306-us58wwmp 24 10 bladder bladder NN cord-015306-us58wwmp 24 11 volume volume NN cord-015306-us58wwmp 24 12 and and CC cord-015306-us58wwmp 24 13 urinary urinary JJ cord-015306-us58wwmp 24 14 tract tract NN cord-015306-us58wwmp 24 15 infection infection NN cord-015306-us58wwmp 24 16 in in IN cord-015306-us58wwmp 24 17 infants infant NNS cord-015306-us58wwmp 24 18 and and CC cord-015306-us58wwmp 24 19 children child NNS cord-015306-us58wwmp 24 20 : : : cord-015306-us58wwmp 25 1 A a DT cord-015306-us58wwmp 25 2 retrospective retrospective JJ cord-015306-us58wwmp 25 3 cohort cohort NN cord-015306-us58wwmp 25 4 study study NN cord-015306-us58wwmp 25 5 Orpheus Orpheus NNP cord-015306-us58wwmp 25 6 Monakil Monakil NNP cord-015306-us58wwmp 25 7 , , , cord-015306-us58wwmp 25 8 Ivy Ivy NNP cord-015306-us58wwmp 25 9 Avilla Avilla NNP cord-015306-us58wwmp 25 10 Department Department NNP cord-015306-us58wwmp 25 11 of of IN cord-015306-us58wwmp 25 12 Pediatrics Pediatrics NNP cord-015306-us58wwmp 25 13 , , , cord-015306-us58wwmp 26 1 Da Da NNP cord-015306-us58wwmp 26 2 La La NNP cord-015306-us58wwmp 26 3 Salle Salle NNP cord-015306-us58wwmp 26 4 University University NNP cord-015306-us58wwmp 26 5 Medical Medical NNP cord-015306-us58wwmp 26 6 , , , cord-015306-us58wwmp 26 7 Philippines Philippines NNP cord-015306-us58wwmp 26 8 Objective Objective NNP cord-015306-us58wwmp 26 9 : : : cord-015306-us58wwmp 26 10 To to TO cord-015306-us58wwmp 26 11 determine determine VB cord-015306-us58wwmp 26 12 the the DT cord-015306-us58wwmp 26 13 association association NN cord-015306-us58wwmp 26 14 between between IN cord-015306-us58wwmp 26 15 post post JJ cord-015306-us58wwmp 26 16 void void JJ cord-015306-us58wwmp 26 17 urine urine NN cord-015306-us58wwmp 26 18 bladder bladder NN cord-015306-us58wwmp 26 19 volume volume NN cord-015306-us58wwmp 26 20 residual residual JJ cord-015306-us58wwmp 26 21 and and CC cord-015306-us58wwmp 26 22 urinary urinary JJ cord-015306-us58wwmp 26 23 tract tract NN cord-015306-us58wwmp 26 24 infection(UTI infection(UTI NNP cord-015306-us58wwmp 26 25 ) ) -RRB- cord-015306-us58wwmp 26 26 in in IN cord-015306-us58wwmp 26 27 children child NNS cord-015306-us58wwmp 26 28 . . . cord-015306-us58wwmp 27 1 Methods method NNS cord-015306-us58wwmp 27 2 : : : cord-015306-us58wwmp 27 3 Medical medical JJ cord-015306-us58wwmp 27 4 records record NNS cord-015306-us58wwmp 27 5 of of IN cord-015306-us58wwmp 27 6 pediatric pediatric JJ cord-015306-us58wwmp 27 7 patients patient NNS cord-015306-us58wwmp 27 8 aged aged JJ cord-015306-us58wwmp 27 9 0 0 CD cord-015306-us58wwmp 27 10 to to IN cord-015306-us58wwmp 27 11 18 18 CD cord-015306-us58wwmp 27 12 years year NNS cord-015306-us58wwmp 27 13 old old JJ cord-015306-us58wwmp 27 14 with with IN cord-015306-us58wwmp 27 15 diagnosis diagnosis NN cord-015306-us58wwmp 27 16 of of IN cord-015306-us58wwmp 27 17 urinary urinary JJ cord-015306-us58wwmp 27 18 tract tract NN cord-015306-us58wwmp 27 19 infection infection NN cord-015306-us58wwmp 27 20 were be VBD cord-015306-us58wwmp 27 21 reviewed review VBN cord-015306-us58wwmp 27 22 . . . cord-015306-us58wwmp 28 1 Demographic demographic JJ cord-015306-us58wwmp 28 2 data datum NNS cord-015306-us58wwmp 28 3 , , , cord-015306-us58wwmp 28 4 urinalysis urinalysis NN cord-015306-us58wwmp 28 5 and and CC cord-015306-us58wwmp 28 6 urine urine NN cord-015306-us58wwmp 28 7 culture culture NN cord-015306-us58wwmp 28 8 results result NNS cord-015306-us58wwmp 28 9 and and CC cord-015306-us58wwmp 28 10 kidney kidney NN cord-015306-us58wwmp 28 11 and and CC cord-015306-us58wwmp 28 12 urinary urinary JJ cord-015306-us58wwmp 28 13 bladder(KUB bladder(KUB NNP cord-015306-us58wwmp 28 14 ) ) -RRB- cord-015306-us58wwmp 29 1 ultrasound ultrasound NN cord-015306-us58wwmp 29 2 findings finding NNS cord-015306-us58wwmp 29 3 were be VBD cord-015306-us58wwmp 29 4 tabulated tabulate VBN cord-015306-us58wwmp 29 5 and and CC cord-015306-us58wwmp 29 6 analyzed analyze VBN cord-015306-us58wwmp 29 7 using use VBG cord-015306-us58wwmp 29 8 the the DT cord-015306-us58wwmp 29 9 95 95 CD cord-015306-us58wwmp 29 10 % % NN cord-015306-us58wwmp 29 11 confidence confidence NN cord-015306-us58wwmp 29 12 interval interval NN cord-015306-us58wwmp 29 13 . . . cord-015306-us58wwmp 30 1 Relative relative JJ cord-015306-us58wwmp 30 2 risks risk NNS cord-015306-us58wwmp 30 3 were be VBD cord-015306-us58wwmp 30 4 computed compute VBN cord-015306-us58wwmp 30 5 with with IN cord-015306-us58wwmp 30 6 a a DT cord-015306-us58wwmp 30 7 level level NN cord-015306-us58wwmp 30 8 of of IN cord-015306-us58wwmp 30 9 significance significance NN cord-015306-us58wwmp 30 10 of of IN cord-015306-us58wwmp 30 11 p p NN cord-015306-us58wwmp 30 12 value value NN cord-015306-us58wwmp 30 13 < < XX cord-015306-us58wwmp 30 14 0.05 0.05 CD cord-015306-us58wwmp 30 15 . . . cord-015306-us58wwmp 31 1 Results result NNS cord-015306-us58wwmp 31 2 : : : cord-015306-us58wwmp 32 1 A a DT cord-015306-us58wwmp 32 2 total total NN cord-015306-us58wwmp 32 3 of of IN cord-015306-us58wwmp 32 4 803 803 CD cord-015306-us58wwmp 32 5 patients patient NNS cord-015306-us58wwmp 32 6 were be VBD cord-015306-us58wwmp 32 7 included include VBN cord-015306-us58wwmp 32 8 in in IN cord-015306-us58wwmp 32 9 the the DT cord-015306-us58wwmp 32 10 study study NN cord-015306-us58wwmp 32 11 . . . cord-015306-us58wwmp 33 1 Five five CD cord-015306-us58wwmp 33 2 hundred hundred CD cord-015306-us58wwmp 33 3 forty forty CD cord-015306-us58wwmp 33 4 - - HYPH cord-015306-us58wwmp 33 5 four(67.8 four(67.8 NN cord-015306-us58wwmp 33 6 % % NN cord-015306-us58wwmp 33 7 ) ) -RRB- cord-015306-us58wwmp 33 8 belongs belong VBZ cord-015306-us58wwmp 33 9 to to IN cord-015306-us58wwmp 33 10 age age NN cord-015306-us58wwmp 33 11 group group NN cord-015306-us58wwmp 33 12 < < XX cord-015306-us58wwmp 33 13 5 5 CD cord-015306-us58wwmp 33 14 years year NNS cord-015306-us58wwmp 33 15 old old JJ cord-015306-us58wwmp 33 16 . . . cord-015306-us58wwmp 34 1 Majority majority NN cord-015306-us58wwmp 34 2 were be VBD cord-015306-us58wwmp 34 3 females female NNS cord-015306-us58wwmp 34 4 with with IN cord-015306-us58wwmp 34 5 a a DT cord-015306-us58wwmp 34 6 0.97:1 0.97:1 CD cord-015306-us58wwmp 34 7 male male NN cord-015306-us58wwmp 34 8 to to IN cord-015306-us58wwmp 34 9 female female JJ cord-015306-us58wwmp 34 10 ratio ratio NN cord-015306-us58wwmp 34 11 . . . cord-015306-us58wwmp 35 1 Escherichia escherichia NN cord-015306-us58wwmp 35 2 coli coli NNS cord-015306-us58wwmp 35 3 is be VBZ cord-015306-us58wwmp 35 4 the the DT cord-015306-us58wwmp 35 5 most most RBS cord-015306-us58wwmp 35 6 common common JJ cord-015306-us58wwmp 35 7 organism organism NN cord-015306-us58wwmp 35 8 isolated isolate VBN cord-015306-us58wwmp 35 9 . . . cord-015306-us58wwmp 36 1 Patients patient NNS cord-015306-us58wwmp 36 2 with with IN cord-015306-us58wwmp 36 3 post post JJ cord-015306-us58wwmp 36 4 void void JJ cord-015306-us58wwmp 36 5 urine urine NN cord-015306-us58wwmp 36 6 bladder bladder NN cord-015306-us58wwmp 36 7 residual residual NN cord-015306-us58wwmp 36 8 are be VBP cord-015306-us58wwmp 36 9 at at IN cord-015306-us58wwmp 36 10 risk risk NN cord-015306-us58wwmp 36 11 for for IN cord-015306-us58wwmp 36 12 having have VBG cord-015306-us58wwmp 36 13 growth growth NN cord-015306-us58wwmp 36 14 in in IN cord-015306-us58wwmp 36 15 the the DT cord-015306-us58wwmp 36 16 urine urine NN cord-015306-us58wwmp 36 17 culture culture NN cord-015306-us58wwmp 36 18 . . . cord-015306-us58wwmp 37 1 In in IN cord-015306-us58wwmp 37 2 sub sub JJ cord-015306-us58wwmp 37 3 group group NN cord-015306-us58wwmp 37 4 analysis analysis NN cord-015306-us58wwmp 37 5 for for IN cord-015306-us58wwmp 37 6 age age NN cord-015306-us58wwmp 37 7 and and CC cord-015306-us58wwmp 37 8 sex sex NN cord-015306-us58wwmp 37 9 , , , cord-015306-us58wwmp 37 10 statistically statistically RB cord-015306-us58wwmp 37 11 significant significant JJ cord-015306-us58wwmp 37 12 results result NNS cord-015306-us58wwmp 37 13 were be VBD cord-015306-us58wwmp 37 14 noted note VBN cord-015306-us58wwmp 37 15 among among IN cord-015306-us58wwmp 37 16 patients patient NNS cord-015306-us58wwmp 37 17 belonging belong VBG cord-015306-us58wwmp 37 18 to to IN cord-015306-us58wwmp 37 19 the the DT cord-015306-us58wwmp 37 20 3 3 CD cord-015306-us58wwmp 37 21 - - SYM cord-015306-us58wwmp 37 22 5 5 CD cord-015306-us58wwmp 37 23 years year NNS cord-015306-us58wwmp 37 24 with with IN cord-015306-us58wwmp 37 25 the the DT cord-015306-us58wwmp 37 26 RR rr NN cord-015306-us58wwmp 37 27 of of IN cord-015306-us58wwmp 37 28 1.337 1.337 CD cord-015306-us58wwmp 37 29 , , , cord-015306-us58wwmp 37 30 95 95 CD cord-015306-us58wwmp 37 31 % % NN cord-015306-us58wwmp 37 32 CI ci NN cord-015306-us58wwmp 37 33 ( ( -LRB- cord-015306-us58wwmp 37 34 1.082 1.082 CD cord-015306-us58wwmp 37 35 , , , cord-015306-us58wwmp 37 36 1.651 1.651 CD cord-015306-us58wwmp 37 37 ) ) -RRB- cord-015306-us58wwmp 38 1 p p NN cord-015306-us58wwmp 38 2 - - HYPH cord-015306-us58wwmp 38 3 value value NN cord-015306-us58wwmp 38 4 of of IN cord-015306-us58wwmp 38 5 0.003 0.003 CD cord-015306-us58wwmp 38 6 and and CC cord-015306-us58wwmp 38 7 males male NNS cord-015306-us58wwmp 38 8 with with IN cord-015306-us58wwmp 38 9 RR RR NNP cord-015306-us58wwmp 38 10 1.186 1.186 CD cord-015306-us58wwmp 38 11 ( ( -LRB- cord-015306-us58wwmp 38 12 95 95 CD cord-015306-us58wwmp 38 13 % % NN cord-015306-us58wwmp 38 14 CI CI NNP cord-015306-us58wwmp 38 15 1.024 1.024 CD cord-015306-us58wwmp 38 16 , , , cord-015306-us58wwmp 38 17 1.374 1.374 CD cord-015306-us58wwmp 38 18 ) ) -RRB- cord-015306-us58wwmp 39 1 p p LS cord-015306-us58wwmp 39 2 value value NN cord-015306-us58wwmp 39 3 0.0168 0.0168 CD cord-015306-us58wwmp 39 4 . . . cord-015306-us58wwmp 40 1 Conclusion conclusion NN cord-015306-us58wwmp 40 2 : : : cord-015306-us58wwmp 40 3 There there EX cord-015306-us58wwmp 40 4 is be VBZ cord-015306-us58wwmp 40 5 an an DT cord-015306-us58wwmp 40 6 association association NN cord-015306-us58wwmp 40 7 between between IN cord-015306-us58wwmp 40 8 the the DT cord-015306-us58wwmp 40 9 occurrence occurrence NN cord-015306-us58wwmp 40 10 of of IN cord-015306-us58wwmp 40 11 urinary urinary JJ cord-015306-us58wwmp 40 12 tract tract NN cord-015306-us58wwmp 40 13 infection infection NN cord-015306-us58wwmp 40 14 and and CC cord-015306-us58wwmp 40 15 the the DT cord-015306-us58wwmp 40 16 presence presence NN cord-015306-us58wwmp 40 17 of of IN cord-015306-us58wwmp 40 18 post post JJ cord-015306-us58wwmp 40 19 void void JJ cord-015306-us58wwmp 40 20 bladder bladder NN cord-015306-us58wwmp 40 21 volume volume NN cord-015306-us58wwmp 40 22 residual residual JJ cord-015306-us58wwmp 40 23 . . . cord-015306-us58wwmp 41 1 Males male NNS cord-015306-us58wwmp 41 2 and and CC cord-015306-us58wwmp 41 3 those those DT cord-015306-us58wwmp 41 4 patients patient NNS cord-015306-us58wwmp 41 5 aged age VBN cord-015306-us58wwmp 41 6 3 3 CD cord-015306-us58wwmp 41 7 to to TO cord-015306-us58wwmp 41 8 5 5 CD cord-015306-us58wwmp 41 9 years year NNS cord-015306-us58wwmp 41 10 of of IN cord-015306-us58wwmp 41 11 age age NN cord-015306-us58wwmp 41 12 are be VBP cord-015306-us58wwmp 41 13 more more JJR cord-015306-us58wwmp 41 14 at at IN cord-015306-us58wwmp 41 15 risk risk NN cord-015306-us58wwmp 41 16 for for IN cord-015306-us58wwmp 41 17 urinary urinary JJ cord-015306-us58wwmp 41 18 infection infection NN cord-015306-us58wwmp 41 19 . . . cord-015306-us58wwmp 42 1 Objective objective NN cord-015306-us58wwmp 42 2 : : : cord-015306-us58wwmp 42 3 To to TO cord-015306-us58wwmp 42 4 evaluate evaluate VB cord-015306-us58wwmp 42 5 if if IN cord-015306-us58wwmp 42 6 a a DT cord-015306-us58wwmp 42 7 relationship relationship NN cord-015306-us58wwmp 42 8 exists exist VBZ cord-015306-us58wwmp 42 9 between between IN cord-015306-us58wwmp 42 10 renal renal JJ cord-015306-us58wwmp 42 11 ultrasound ultrasound NN cord-015306-us58wwmp 42 12 and and CC cord-015306-us58wwmp 42 13 voiding void VBG cord-015306-us58wwmp 42 14 cystourethrography cystourethrography NNP cord-015306-us58wwmp 42 15 ( ( -LRB- cord-015306-us58wwmp 42 16 VCUG VCUG NNP cord-015306-us58wwmp 42 17 ) ) -RRB- cord-015306-us58wwmp 42 18 findings finding NNS cord-015306-us58wwmp 42 19 among among IN cord-015306-us58wwmp 42 20 children child NNS cord-015306-us58wwmp 42 21 with with IN cord-015306-us58wwmp 42 22 UTI UTI NNP cord-015306-us58wwmp 42 23 and and CC cord-015306-us58wwmp 42 24 determine determine VB cord-015306-us58wwmp 42 25 whether whether IN cord-015306-us58wwmp 42 26 the the DT cord-015306-us58wwmp 42 27 renal renal JJ cord-015306-us58wwmp 42 28 ultrasound ultrasound NN cord-015306-us58wwmp 42 29 findings finding NNS cord-015306-us58wwmp 42 30 / / SYM cord-015306-us58wwmp 42 31 results result NNS cord-015306-us58wwmp 42 32 can can MD cord-015306-us58wwmp 42 33 serve serve VB cord-015306-us58wwmp 42 34 as as IN cord-015306-us58wwmp 42 35 a a DT cord-015306-us58wwmp 42 36 guide guide NN cord-015306-us58wwmp 42 37 if if IN cord-015306-us58wwmp 42 38 a a DT cord-015306-us58wwmp 42 39 procedure procedure NN cord-015306-us58wwmp 42 40 such such JJ cord-015306-us58wwmp 42 41 as as IN cord-015306-us58wwmp 42 42 VCUG VCUG NNP cord-015306-us58wwmp 42 43 is be VBZ cord-015306-us58wwmp 42 44 needed need VBN cord-015306-us58wwmp 42 45 to to TO cord-015306-us58wwmp 42 46 be be VB cord-015306-us58wwmp 42 47 done do VBN cord-015306-us58wwmp 42 48 in in IN cord-015306-us58wwmp 42 49 the the DT cord-015306-us58wwmp 42 50 patient patient NN cord-015306-us58wwmp 42 51 . . . cord-015306-us58wwmp 43 1 Methods method NNS cord-015306-us58wwmp 43 2 : : : cord-015306-us58wwmp 43 3 Medical medical JJ cord-015306-us58wwmp 43 4 records record NNS cord-015306-us58wwmp 43 5 of of IN cord-015306-us58wwmp 43 6 infants infant NNS cord-015306-us58wwmp 43 7 and and CC cord-015306-us58wwmp 43 8 children child NNS cord-015306-us58wwmp 43 9 diagnosed diagnose VBN cord-015306-us58wwmp 43 10 as as IN cord-015306-us58wwmp 43 11 having have VBG cord-015306-us58wwmp 43 12 UTI UTI NNP cord-015306-us58wwmp 43 13 who who WP cord-015306-us58wwmp 43 14 underwent undergo VBD cord-015306-us58wwmp 43 15 renal renal JJ cord-015306-us58wwmp 43 16 ultrasound ultrasound NN cord-015306-us58wwmp 43 17 and and CC cord-015306-us58wwmp 43 18 VCUG VCUG NNP cord-015306-us58wwmp 43 19 were be VBD cord-015306-us58wwmp 43 20 reviewed review VBN cord-015306-us58wwmp 43 21 . . . cord-015306-us58wwmp 44 1 Demographic demographic JJ cord-015306-us58wwmp 44 2 data datum NNS cord-015306-us58wwmp 44 3 , , , cord-015306-us58wwmp 44 4 urine urine NN cord-015306-us58wwmp 44 5 culture culture NN cord-015306-us58wwmp 44 6 and and CC cord-015306-us58wwmp 44 7 results result NNS cord-015306-us58wwmp 44 8 of of IN cord-015306-us58wwmp 44 9 imaging imaging NN cord-015306-us58wwmp 44 10 studies study NNS cord-015306-us58wwmp 44 11 were be VBD cord-015306-us58wwmp 44 12 tabulated tabulate VBN cord-015306-us58wwmp 44 13 and and CC cord-015306-us58wwmp 44 14 analyzed analyze VBN cord-015306-us58wwmp 44 15 . . . cord-015306-us58wwmp 45 1 Kappa Kappa NNP cord-015306-us58wwmp 45 2 statistics statistic NNS cord-015306-us58wwmp 45 3 was be VBD cord-015306-us58wwmp 45 4 used use VBN cord-015306-us58wwmp 45 5 to to TO cord-015306-us58wwmp 45 6 determine determine VB cord-015306-us58wwmp 45 7 the the DT cord-015306-us58wwmp 45 8 agreement agreement NN cord-015306-us58wwmp 45 9 between between IN cord-015306-us58wwmp 45 10 renal renal JJ cord-015306-us58wwmp 45 11 ultrasound ultrasound NN cord-015306-us58wwmp 45 12 and and CC cord-015306-us58wwmp 45 13 VCUG vcug NN cord-015306-us58wwmp 45 14 results result NNS cord-015306-us58wwmp 45 15 . . . cord-015306-us58wwmp 46 1 McNemars McNemars NNP cord-015306-us58wwmp 46 2 test test NN cord-015306-us58wwmp 46 3 was be VBD cord-015306-us58wwmp 46 4 utilized utilize VBN cord-015306-us58wwmp 46 5 to to TO cord-015306-us58wwmp 46 6 determine determine VB cord-015306-us58wwmp 46 7 the the DT cord-015306-us58wwmp 46 8 statistical statistical JJ cord-015306-us58wwmp 46 9 significance significance NN cord-015306-us58wwmp 46 10 of of IN cord-015306-us58wwmp 46 11 the the DT cord-015306-us58wwmp 46 12 agreement agreement NN cord-015306-us58wwmp 46 13 . . . cord-015306-us58wwmp 47 1 Level level NN cord-015306-us58wwmp 47 2 of of IN cord-015306-us58wwmp 47 3 significance significance NN cord-015306-us58wwmp 47 4 was be VBD cord-015306-us58wwmp 47 5 place place NN cord-015306-us58wwmp 47 6 at at IN cord-015306-us58wwmp 47 7 p p NN cord-015306-us58wwmp 47 8 value value NN cord-015306-us58wwmp 47 9 of of IN cord-015306-us58wwmp 47 10 < < NNP cord-015306-us58wwmp 47 11 0.05 0.05 CD cord-015306-us58wwmp 47 12 . . . cord-015306-us58wwmp 48 1 Results result NNS cord-015306-us58wwmp 48 2 : : : cord-015306-us58wwmp 49 1 A a DT cord-015306-us58wwmp 49 2 total total NN cord-015306-us58wwmp 49 3 of of IN cord-015306-us58wwmp 49 4 146 146 CD cord-015306-us58wwmp 49 5 patients patient NNS cord-015306-us58wwmp 49 6 were be VBD cord-015306-us58wwmp 49 7 included include VBN cord-015306-us58wwmp 49 8 in in IN cord-015306-us58wwmp 49 9 the the DT cord-015306-us58wwmp 49 10 study study NN cord-015306-us58wwmp 49 11 . . . cord-015306-us58wwmp 50 1 Thirtyeight(26 Thirtyeight(26 NNP cord-015306-us58wwmp 50 2 % % NN cord-015306-us58wwmp 50 3 ) ) -RRB- cord-015306-us58wwmp 50 4 had have VBD cord-015306-us58wwmp 50 5 vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 50 6 reflux reflux NN cord-015306-us58wwmp 50 7 . . . cord-015306-us58wwmp 51 1 There there EX cord-015306-us58wwmp 51 2 were be VBD cord-015306-us58wwmp 51 3 more more JJR cord-015306-us58wwmp 51 4 females female NNS cord-015306-us58wwmp 51 5 with with IN cord-015306-us58wwmp 51 6 a a DT cord-015306-us58wwmp 51 7 male male NN cord-015306-us58wwmp 51 8 to to IN cord-015306-us58wwmp 51 9 female female JJ cord-015306-us58wwmp 51 10 ratio ratio NN cord-015306-us58wwmp 51 11 of of IN cord-015306-us58wwmp 51 12 1:1.3 1:1.3 CD cord-015306-us58wwmp 51 13 while while IN cord-015306-us58wwmp 51 14 cases case NNS cord-015306-us58wwmp 51 15 with with IN cord-015306-us58wwmp 51 16 reflux reflux NN cord-015306-us58wwmp 51 17 had have VBD cord-015306-us58wwmp 51 18 a a DT cord-015306-us58wwmp 51 19 1:1.5 1:1.5 CD cord-015306-us58wwmp 51 20 male male NN cord-015306-us58wwmp 51 21 to to IN cord-015306-us58wwmp 51 22 female female JJ cord-015306-us58wwmp 51 23 ratio ratio NN cord-015306-us58wwmp 51 24 . . . cord-015306-us58wwmp 52 1 Most most RBS cord-015306-us58wwmp 52 2 common common JJ cord-015306-us58wwmp 52 3 chief chief JJ cord-015306-us58wwmp 52 4 complaint complaint NN cord-015306-us58wwmp 52 5 was be VBD cord-015306-us58wwmp 52 6 fever fever NN cord-015306-us58wwmp 52 7 . . . cord-015306-us58wwmp 53 1 E. E. NNP cord-015306-us58wwmp 53 2 coli coli NNS cord-015306-us58wwmp 53 3 is be VBZ cord-015306-us58wwmp 53 4 the the DT cord-015306-us58wwmp 53 5 most most RBS cord-015306-us58wwmp 53 6 commonly commonly RB cord-015306-us58wwmp 53 7 isolated isolate VBN cord-015306-us58wwmp 53 8 etiologic etiologic JJ cord-015306-us58wwmp 53 9 organism organism NN cord-015306-us58wwmp 53 10 from from IN cord-015306-us58wwmp 53 11 the the DT cord-015306-us58wwmp 53 12 urine urine NN cord-015306-us58wwmp 53 13 . . . cord-015306-us58wwmp 54 1 Twenty(52.7 Twenty(52.7 `` cord-015306-us58wwmp 54 2 % % NN cord-015306-us58wwmp 54 3 ) ) -RRB- cord-015306-us58wwmp 55 1 patients patient NNS cord-015306-us58wwmp 55 2 had have VBD cord-015306-us58wwmp 55 3 primary primary JJ cord-015306-us58wwmp 55 4 VUR VUR NNP cord-015306-us58wwmp 55 5 while while IN cord-015306-us58wwmp 55 6 18(47.3 18(47.3 CD cord-015306-us58wwmp 55 7 % % NN cord-015306-us58wwmp 55 8 ) ) -RRB- cord-015306-us58wwmp 55 9 were be VBD cord-015306-us58wwmp 55 10 secondary secondary JJ cord-015306-us58wwmp 55 11 . . . cord-015306-us58wwmp 56 1 Fifty fifty CD cord-015306-us58wwmp 56 2 two two CD cord-015306-us58wwmp 56 3 of of IN cord-015306-us58wwmp 56 4 146 146 CD cord-015306-us58wwmp 56 5 children child NNS cord-015306-us58wwmp 56 6 had have VBD cord-015306-us58wwmp 56 7 abnormal abnormal JJ cord-015306-us58wwmp 56 8 sonogram sonogram NN cord-015306-us58wwmp 56 9 ; ; : cord-015306-us58wwmp 56 10 of of IN cord-015306-us58wwmp 56 11 duplex duplex NN cord-015306-us58wwmp 56 12 collecting collecting NN cord-015306-us58wwmp 56 13 system system NN cord-015306-us58wwmp 56 14 ( ( -LRB- cord-015306-us58wwmp 56 15 DCS DCS NNP cord-015306-us58wwmp 56 16 ) ) -RRB- cord-015306-us58wwmp 56 17 diagnosed diagnose VBD cord-015306-us58wwmp 56 18 during during IN cord-015306-us58wwmp 56 19 postnatal postnatal JJ cord-015306-us58wwmp 56 20 USC USC NNP cord-015306-us58wwmp 56 21 on on IN cord-015306-us58wwmp 56 22 Objective Objective NNP cord-015306-us58wwmp 56 23 : : : cord-015306-us58wwmp 56 24 The the DT cord-015306-us58wwmp 56 25 aim aim NN cord-015306-us58wwmp 56 26 was be VBD cord-015306-us58wwmp 56 27 to to TO cord-015306-us58wwmp 56 28 evaluate evaluate VB cord-015306-us58wwmp 56 29 the the DT cord-015306-us58wwmp 56 30 relationship relationship NN cord-015306-us58wwmp 56 31 of of IN cord-015306-us58wwmp 56 32 laboratory laboratory NN cord-015306-us58wwmp 56 33 investigations investigation NNS cord-015306-us58wwmp 56 34 , , , cord-015306-us58wwmp 56 35 therapeutic therapeutic JJ cord-015306-us58wwmp 56 36 delay delay NN cord-015306-us58wwmp 56 37 time time NN cord-015306-us58wwmp 56 38 ( ( -LRB- cord-015306-us58wwmp 56 39 TDT TDT NNP cord-015306-us58wwmp 56 40 ) ) -RRB- cord-015306-us58wwmp 56 41 , , , cord-015306-us58wwmp 56 42 and and CC cord-015306-us58wwmp 56 43 therapeutic therapeutic JJ cord-015306-us58wwmp 56 44 response response NN cord-015306-us58wwmp 56 45 time time NN cord-015306-us58wwmp 56 46 ( ( -LRB- cord-015306-us58wwmp 56 47 TRT TRT NNP cord-015306-us58wwmp 56 48 ) ) -RRB- cord-015306-us58wwmp 56 49 with with IN cord-015306-us58wwmp 56 50 acute acute JJ cord-015306-us58wwmp 56 51 renal renal JJ cord-015306-us58wwmp 56 52 damage damage NN cord-015306-us58wwmp 56 53 and and CC cord-015306-us58wwmp 56 54 to to TO cord-015306-us58wwmp 56 55 verify verify VB cord-015306-us58wwmp 56 56 these these DT cord-015306-us58wwmp 56 57 parameters parameter NNS cord-015306-us58wwmp 56 58 in in IN cord-015306-us58wwmp 56 59 the the DT cord-015306-us58wwmp 56 60 presence presence NN cord-015306-us58wwmp 56 61 of of IN cord-015306-us58wwmp 56 62 non non AFX cord-015306-us58wwmp 56 63 refluxing refluxing NN cord-015306-us58wwmp 56 64 and and CC cord-015306-us58wwmp 56 65 refluxing refluxe VBG cord-015306-us58wwmp 56 66 urinary urinary JJ cord-015306-us58wwmp 56 67 tract tract NN cord-015306-us58wwmp 56 68 infection infection NN cord-015306-us58wwmp 56 69 ( ( -LRB- cord-015306-us58wwmp 56 70 UTI UTI NNP cord-015306-us58wwmp 56 71 ) ) -RRB- cord-015306-us58wwmp 56 72 . . . cord-015306-us58wwmp 57 1 Methods method NNS cord-015306-us58wwmp 57 2 : : : cord-015306-us58wwmp 58 1 A a DT cord-015306-us58wwmp 58 2 prospective prospective JJ cord-015306-us58wwmp 58 3 study study NN cord-015306-us58wwmp 58 4 was be VBD cord-015306-us58wwmp 58 5 conducted conduct VBN cord-015306-us58wwmp 58 6 in in IN cord-015306-us58wwmp 58 7 67 67 CD cord-015306-us58wwmp 58 8 children child NNS cord-015306-us58wwmp 58 9 . . . cord-015306-us58wwmp 59 1 All all DT cord-015306-us58wwmp 59 2 patients patient NNS cord-015306-us58wwmp 59 3 received receive VBD cord-015306-us58wwmp 59 4 voiding void VBG cord-015306-us58wwmp 59 5 cystourethrography cystourethrography NNP cord-015306-us58wwmp 59 6 ( ( -LRB- cord-015306-us58wwmp 59 7 VCUG VCUG NNP cord-015306-us58wwmp 59 8 ) ) -RRB- cord-015306-us58wwmp 59 9 and and CC cord-015306-us58wwmp 59 10 dimercaptosuccinic dimercaptosuccinic JJ cord-015306-us58wwmp 59 11 acid acid NN cord-015306-us58wwmp 59 12 ( ( -LRB- cord-015306-us58wwmp 59 13 DMSA DMSA NNP cord-015306-us58wwmp 59 14 ) ) -RRB- cord-015306-us58wwmp 59 15 renal renal JJ cord-015306-us58wwmp 59 16 scintigraphy scintigraphy NN cord-015306-us58wwmp 59 17 . . . cord-015306-us58wwmp 60 1 Statistical statistical JJ cord-015306-us58wwmp 60 2 analyses analysis NNS cord-015306-us58wwmp 60 3 were be VBD cord-015306-us58wwmp 60 4 applied apply VBN cord-015306-us58wwmp 60 5 to to TO cord-015306-us58wwmp 60 6 assess assess VB cord-015306-us58wwmp 60 7 all all DT cord-015306-us58wwmp 60 8 parameters parameter NNS cord-015306-us58wwmp 60 9 with with IN cord-015306-us58wwmp 60 10 DMSA dmsa JJ cord-015306-us58wwmp 60 11 renal renal JJ cord-015306-us58wwmp 60 12 scintigraphy scintigraphy NN cord-015306-us58wwmp 60 13 . . . cord-015306-us58wwmp 61 1 Results result NNS cord-015306-us58wwmp 61 2 : : : cord-015306-us58wwmp 62 1 Abnormal abnormal JJ cord-015306-us58wwmp 62 2 DMSA DMSA NNS cord-015306-us58wwmp 62 3 renal renal JJ cord-015306-us58wwmp 62 4 scintigraphy scintigraphy NN cord-015306-us58wwmp 62 5 was be VBD cord-015306-us58wwmp 62 6 detected detect VBN cord-015306-us58wwmp 62 7 in in IN cord-015306-us58wwmp 62 8 20/67 20/67 CD cord-015306-us58wwmp 62 9 ( ( -LRB- cord-015306-us58wwmp 62 10 29.9 29.9 CD cord-015306-us58wwmp 62 11 % % NN cord-015306-us58wwmp 62 12 ) ) -RRB- cord-015306-us58wwmp 62 13 patients patient NNS cord-015306-us58wwmp 62 14 . . . cord-015306-us58wwmp 63 1 There there EX cord-015306-us58wwmp 63 2 were be VBD cord-015306-us58wwmp 63 3 no no DT cord-015306-us58wwmp 63 4 significant significant JJ cord-015306-us58wwmp 63 5 differences difference NNS cord-015306-us58wwmp 63 6 in in IN cord-015306-us58wwmp 63 7 peak peak NN cord-015306-us58wwmp 63 8 temperature temperature NN cord-015306-us58wwmp 63 9 , , , cord-015306-us58wwmp 63 10 TDT tdt NN cord-015306-us58wwmp 63 11 and and CC cord-015306-us58wwmp 63 12 treatment treatment NN cord-015306-us58wwmp 63 13 duration duration NN cord-015306-us58wwmp 63 14 . . . cord-015306-us58wwmp 64 1 However however RB cord-015306-us58wwmp 64 2 , , , cord-015306-us58wwmp 64 3 white white JJ cord-015306-us58wwmp 64 4 blood blood NN cord-015306-us58wwmp 64 5 cells cell NNS cord-015306-us58wwmp 64 6 ( ( -LRB- cord-015306-us58wwmp 64 7 WBC WBC NNP cord-015306-us58wwmp 64 8 ) ) -RRB- cord-015306-us58wwmp 64 9 count count NN cord-015306-us58wwmp 64 10 , , , cord-015306-us58wwmp 64 11 percentage percentage NN cord-015306-us58wwmp 64 12 of of IN cord-015306-us58wwmp 64 13 serum serum NN cord-015306-us58wwmp 64 14 polymorphonuclear polymorphonuclear NN cord-015306-us58wwmp 64 15 cells cell NNS cord-015306-us58wwmp 64 16 ( ( -LRB- cord-015306-us58wwmp 64 17 % % NN cord-015306-us58wwmp 64 18 PMN PMN NNP cord-015306-us58wwmp 64 19 ) ) -RRB- cord-015306-us58wwmp 64 20 and and CC cord-015306-us58wwmp 64 21 TRT TRT NNP cord-015306-us58wwmp 64 22 had have VBD cord-015306-us58wwmp 64 23 significant significant JJ cord-015306-us58wwmp 64 24 differences difference NNS cord-015306-us58wwmp 64 25 at at IN cord-015306-us58wwmp 64 26 p p NN cord-015306-us58wwmp 64 27 - - HYPH cord-015306-us58wwmp 64 28 values value NNS cord-015306-us58wwmp 64 29 0.042 0.042 CD cord-015306-us58wwmp 64 30 , , , cord-015306-us58wwmp 64 31 < < XX cord-015306-us58wwmp 64 32 0.001 0.001 CD cord-015306-us58wwmp 64 33 and and CC cord-015306-us58wwmp 64 34 0.001 0.001 CD cord-015306-us58wwmp 64 35 , , , cord-015306-us58wwmp 64 36 respectively respectively RB cord-015306-us58wwmp 64 37 . . . cord-015306-us58wwmp 65 1 The the DT cord-015306-us58wwmp 65 2 area area NN cord-015306-us58wwmp 65 3 under under IN cord-015306-us58wwmp 65 4 ROC ROC NNP cord-015306-us58wwmp 65 5 curve curve NN cord-015306-us58wwmp 65 6 for for IN cord-015306-us58wwmp 65 7 WBC WBC NNP cord-015306-us58wwmp 65 8 count count NN cord-015306-us58wwmp 65 9 , , , cord-015306-us58wwmp 65 10 % % NN cord-015306-us58wwmp 65 11 PMN PMN NNP cord-015306-us58wwmp 65 12 and and CC cord-015306-us58wwmp 65 13 TRT TRT NNP cord-015306-us58wwmp 65 14 was be VBD cord-015306-us58wwmp 65 15 0.653 0.653 CD cord-015306-us58wwmp 65 16 ( ( -LRB- cord-015306-us58wwmp 65 17 95%CI 95%ci CD cord-015306-us58wwmp 65 18 0.509 0.509 CD cord-015306-us58wwmp 65 19 - - HYPH cord-015306-us58wwmp 65 20 0.798 0.798 CD cord-015306-us58wwmp 65 21 ) ) -RRB- cord-015306-us58wwmp 65 22 at at IN cord-015306-us58wwmp 65 23 p p NN cord-015306-us58wwmp 65 24 - - HYPH cord-015306-us58wwmp 65 25 values value NNS cord-015306-us58wwmp 65 26 0.055 0.055 CD cord-015306-us58wwmp 65 27 , , , cord-015306-us58wwmp 65 28 0.799 0.799 CD cord-015306-us58wwmp 66 1 ( ( -LRB- cord-015306-us58wwmp 66 2 95%CI 95%ci CD cord-015306-us58wwmp 66 3 0.681 0.681 CD cord-015306-us58wwmp 66 4 - - HYPH cord-015306-us58wwmp 66 5 0.888 0.888 CD cord-015306-us58wwmp 66 6 ) ) -RRB- cord-015306-us58wwmp 67 1 at at IN cord-015306-us58wwmp 67 2 p p NN cord-015306-us58wwmp 67 3 - - HYPH cord-015306-us58wwmp 67 4 values value NNS cord-015306-us58wwmp 67 5 < < XX cord-015306-us58wwmp 67 6 0.001 0.001 CD cord-015306-us58wwmp 67 7 and and CC cord-015306-us58wwmp 67 8 0.760 0.760 CD cord-015306-us58wwmp 68 1 ( ( -LRB- cord-015306-us58wwmp 68 2 95%CI 95%ci CD cord-015306-us58wwmp 68 3 0.637 0.637 CD cord-015306-us58wwmp 68 4 - - HYPH cord-015306-us58wwmp 68 5 0.858 0.858 CD cord-015306-us58wwmp 68 6 ) ) -RRB- cord-015306-us58wwmp 68 7 at at IN cord-015306-us58wwmp 68 8 p p NN cord-015306-us58wwmp 68 9 - - HYPH cord-015306-us58wwmp 68 10 value value NN cord-015306-us58wwmp 68 11 0.001 0.001 CD cord-015306-us58wwmp 68 12 , , , cord-015306-us58wwmp 68 13 respectively respectively RB cord-015306-us58wwmp 68 14 . . . cord-015306-us58wwmp 69 1 Overall overall RB cord-015306-us58wwmp 69 2 , , , cord-015306-us58wwmp 69 3 the the DT cord-015306-us58wwmp 69 4 optimal optimal JJ cord-015306-us58wwmp 69 5 cutoff cutoff NN cord-015306-us58wwmp 69 6 value value NN cord-015306-us58wwmp 69 7 for for IN cord-015306-us58wwmp 69 8 % % NN cord-015306-us58wwmp 69 9 PMN PMN NNP cord-015306-us58wwmp 69 10 was be VBD cord-015306-us58wwmp 69 11 56.0 56.0 CD cord-015306-us58wwmp 69 12 with with IN cord-015306-us58wwmp 69 13 sensitivity sensitivity NN cord-015306-us58wwmp 69 14 84.2 84.2 CD cord-015306-us58wwmp 69 15 % % NN cord-015306-us58wwmp 69 16 ( ( -LRB- cord-015306-us58wwmp 69 17 60 60 CD cord-015306-us58wwmp 69 18 . . . cord-015306-us58wwmp 70 1 4 4 LS cord-015306-us58wwmp 70 2 - - SYM cord-015306-us58wwmp 70 3 96.4 96.4 CD cord-015306-us58wwmp 70 4 ) ) -RRB- cord-015306-us58wwmp 70 5 and and CC cord-015306-us58wwmp 70 6 specificity specificity NN cord-015306-us58wwmp 70 7 60 60 CD cord-015306-us58wwmp 70 8 . . . cord-015306-us58wwmp 71 1 9 9 CD cord-015306-us58wwmp 71 2 % % NN cord-015306-us58wwmp 71 3 ( ( -LRB- cord-015306-us58wwmp 71 4 45.4 45.4 CD cord-015306-us58wwmp 71 5 - - HYPH cord-015306-us58wwmp 71 6 74.9 74.9 CD cord-015306-us58wwmp 71 7 ) ) -RRB- cord-015306-us58wwmp 71 8 . . . cord-015306-us58wwmp 72 1 The the DT cord-015306-us58wwmp 72 2 optimal optimal JJ cord-015306-us58wwmp 72 3 cut cut VB cord-015306-us58wwmp 72 4 - - HYPH cord-015306-us58wwmp 72 5 off off RP cord-015306-us58wwmp 72 6 value value NN cord-015306-us58wwmp 72 7 for for IN cord-015306-us58wwmp 72 8 TRT TRT NNP cord-015306-us58wwmp 72 9 was be VBD cord-015306-us58wwmp 72 10 22 22 CD cord-015306-us58wwmp 72 11 hours hour NNS cord-015306-us58wwmp 72 12 with with IN cord-015306-us58wwmp 72 13 sensitivity sensitivity NN cord-015306-us58wwmp 72 14 80.0 80.0 CD cord-015306-us58wwmp 72 15 % % NN cord-015306-us58wwmp 72 16 ( ( -LRB- cord-015306-us58wwmp 72 17 56.3 56.3 CD cord-015306-us58wwmp 72 18 - - SYM cord-015306-us58wwmp 72 19 94.1 94.1 CD cord-015306-us58wwmp 72 20 ) ) -RRB- cord-015306-us58wwmp 72 21 and and CC cord-015306-us58wwmp 72 22 specificity specificity NN cord-015306-us58wwmp 72 23 63 63 CD cord-015306-us58wwmp 72 24 . . . cord-015306-us58wwmp 73 1 6 6 CD cord-015306-us58wwmp 73 2 % % NN cord-015306-us58wwmp 73 3 ( ( -LRB- cord-015306-us58wwmp 73 4 47.8 47.8 CD cord-015306-us58wwmp 73 5 - - HYPH cord-015306-us58wwmp 73 6 77.6 77.6 CD cord-015306-us58wwmp 73 7 ) ) -RRB- cord-015306-us58wwmp 73 8 . . . cord-015306-us58wwmp 74 1 In in IN cord-015306-us58wwmp 74 2 50 50 CD cord-015306-us58wwmp 74 3 patients patient NNS cord-015306-us58wwmp 74 4 with with IN cord-015306-us58wwmp 74 5 no no DT cord-015306-us58wwmp 74 6 vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 74 7 reflux reflux NN cord-015306-us58wwmp 74 8 ( ( -LRB- cord-015306-us58wwmp 74 9 VUR VUR NNP cord-015306-us58wwmp 74 10 ) ) -RRB- cord-015306-us58wwmp 74 11 , , , cord-015306-us58wwmp 74 12 there there EX cord-015306-us58wwmp 74 13 was be VBD cord-015306-us58wwmp 74 14 significant significant JJ cord-015306-us58wwmp 74 15 difference difference NN cord-015306-us58wwmp 74 16 in in IN cord-015306-us58wwmp 74 17 TRT TRT NNP cord-015306-us58wwmp 74 18 at at IN cord-015306-us58wwmp 74 19 p p NN cord-015306-us58wwmp 74 20 - - HYPH cord-015306-us58wwmp 74 21 values value NNS cord-015306-us58wwmp 74 22 0.002 0.002 CD cord-015306-us58wwmp 74 23 . . . cord-015306-us58wwmp 75 1 The the DT cord-015306-us58wwmp 75 2 area area NN cord-015306-us58wwmp 75 3 under under IN cord-015306-us58wwmp 75 4 ROC ROC NNP cord-015306-us58wwmp 75 5 curve curve NN cord-015306-us58wwmp 75 6 for for IN cord-015306-us58wwmp 75 7 TRT TRT NNP cord-015306-us58wwmp 75 8 was be VBD cord-015306-us58wwmp 75 9 0.824 0.824 CD cord-015306-us58wwmp 75 10 ( ( -LRB- cord-015306-us58wwmp 75 11 95%CI 95%ci CD cord-015306-us58wwmp 75 12 0.693 0.693 CD cord-015306-us58wwmp 75 13 - - HYPH cord-015306-us58wwmp 75 14 0.955 0.955 CD cord-015306-us58wwmp 75 15 ) ) -RRB- cord-015306-us58wwmp 76 1 at at IN cord-015306-us58wwmp 76 2 p p NN cord-015306-us58wwmp 76 3 - - HYPH cord-015306-us58wwmp 76 4 value value NN cord-015306-us58wwmp 76 5 0.004 0.004 CD cord-015306-us58wwmp 76 6 . . . cord-015306-us58wwmp 77 1 The the DT cord-015306-us58wwmp 77 2 optimal optimal JJ cord-015306-us58wwmp 77 3 cut cut VB cord-015306-us58wwmp 77 4 - - HYPH cord-015306-us58wwmp 77 5 off off RP cord-015306-us58wwmp 77 6 value value NN cord-015306-us58wwmp 77 7 for for IN cord-015306-us58wwmp 77 8 TRT TRT NNP cord-015306-us58wwmp 77 9 was be VBD cord-015306-us58wwmp 77 10 25 25 CD cord-015306-us58wwmp 77 11 hours hour NNS cord-015306-us58wwmp 77 12 with with IN cord-015306-us58wwmp 77 13 sensitivity sensitivity NN cord-015306-us58wwmp 77 14 88.9 88.9 CD cord-015306-us58wwmp 77 15 % % NN cord-015306-us58wwmp 77 16 ( ( -LRB- cord-015306-us58wwmp 77 17 95%CI 95%ci CD cord-015306-us58wwmp 77 18 51.7 51.7 CD cord-015306-us58wwmp 77 19 - - HYPH cord-015306-us58wwmp 77 20 98.2 98.2 CD cord-015306-us58wwmp 77 21 ) ) -RRB- cord-015306-us58wwmp 77 22 and and CC cord-015306-us58wwmp 77 23 specificity specificity NN cord-015306-us58wwmp 77 24 68.4 68.4 CD cord-015306-us58wwmp 77 25 % % NN cord-015306-us58wwmp 77 26 . . . cord-015306-us58wwmp 78 1 In in IN cord-015306-us58wwmp 78 2 VUR VUR NNP cord-015306-us58wwmp 78 3 patients patient NNS cord-015306-us58wwmp 78 4 , , , cord-015306-us58wwmp 78 5 there there EX cord-015306-us58wwmp 78 6 were be VBD cord-015306-us58wwmp 78 7 no no DT cord-015306-us58wwmp 78 8 significant significant JJ cord-015306-us58wwmp 78 9 differences difference NNS cord-015306-us58wwmp 78 10 in in IN cord-015306-us58wwmp 78 11 TDT TDT NNP cord-015306-us58wwmp 78 12 , , , cord-015306-us58wwmp 78 13 % % NN cord-015306-us58wwmp 78 14 PMN PMN NNP cord-015306-us58wwmp 78 15 and and CC cord-015306-us58wwmp 78 16 TRT TRT NNP cord-015306-us58wwmp 78 17 between between IN cord-015306-us58wwmp 78 18 normal normal JJ cord-015306-us58wwmp 78 19 and and CC cord-015306-us58wwmp 78 20 abnormal abnormal JJ cord-015306-us58wwmp 78 21 DMSA DMSA NNS cord-015306-us58wwmp 78 22 renal renal JJ cord-015306-us58wwmp 78 23 scintigraphy scintigraphy NN cord-015306-us58wwmp 78 24 at at IN cord-015306-us58wwmp 78 25 p p NN cord-015306-us58wwmp 78 26 - - HYPH cord-015306-us58wwmp 78 27 value value NN cord-015306-us58wwmp 78 28 0.750 0.750 CD cord-015306-us58wwmp 78 29 , , , cord-015306-us58wwmp 78 30 0.191 0.191 CD cord-015306-us58wwmp 78 31 and and CC cord-015306-us58wwmp 78 32 0.313 0.313 CD cord-015306-us58wwmp 78 33 , , , cord-015306-us58wwmp 78 34 respectively respectively RB cord-015306-us58wwmp 78 35 . . . cord-015306-us58wwmp 79 1 Conclusion conclusion NN cord-015306-us58wwmp 79 2 : : : cord-015306-us58wwmp 79 3 % % NN cord-015306-us58wwmp 79 4 PMN pmn NN cord-015306-us58wwmp 79 5 ≥56 ≥56 NNP cord-015306-us58wwmp 79 6 % % NN cord-015306-us58wwmp 79 7 and and CC cord-015306-us58wwmp 79 8 TRT TRT NNP cord-015306-us58wwmp 79 9 ≥22 ≥22 NNP cord-015306-us58wwmp 79 10 hours hour NNS cord-015306-us58wwmp 79 11 predict predict VBP cord-015306-us58wwmp 79 12 renal renal JJ cord-015306-us58wwmp 79 13 damage damage NN cord-015306-us58wwmp 79 14 in in IN cord-015306-us58wwmp 79 15 the the DT cord-015306-us58wwmp 79 16 first first JJ cord-015306-us58wwmp 79 17 episode episode NN cord-015306-us58wwmp 79 18 of of IN cord-015306-us58wwmp 79 19 UTI UTI NNP cord-015306-us58wwmp 79 20 . . . cord-015306-us58wwmp 80 1 However however RB cord-015306-us58wwmp 80 2 , , , cord-015306-us58wwmp 80 3 in in IN cord-015306-us58wwmp 80 4 patients patient NNS cord-015306-us58wwmp 80 5 with with IN cord-015306-us58wwmp 80 6 no no DT cord-015306-us58wwmp 80 7 VUR VUR NNP cord-015306-us58wwmp 80 8 , , , cord-015306-us58wwmp 80 9 TRT TRT NNP cord-015306-us58wwmp 80 10 ≥25 ≥25 NNP cord-015306-us58wwmp 80 11 hours hour NNS cord-015306-us58wwmp 80 12 predict predict VBP cord-015306-us58wwmp 80 13 renal renal JJ cord-015306-us58wwmp 80 14 damage damage NN cord-015306-us58wwmp 80 15 . . . cord-015306-us58wwmp 81 1 DMSA DMSA NNP cord-015306-us58wwmp 81 2 renal renal JJ cord-015306-us58wwmp 81 3 scintigraphy scintigraphy NN cord-015306-us58wwmp 81 4 in in IN cord-015306-us58wwmp 81 5 the the DT cord-015306-us58wwmp 81 6 first first JJ cord-015306-us58wwmp 81 7 episode episode NN cord-015306-us58wwmp 81 8 of of IN cord-015306-us58wwmp 81 9 UTI UTI NNP cord-015306-us58wwmp 81 10 should should MD cord-015306-us58wwmp 81 11 be be VB cord-015306-us58wwmp 81 12 considered consider VBN cord-015306-us58wwmp 81 13 in in IN cord-015306-us58wwmp 81 14 those those DT cord-015306-us58wwmp 81 15 patients patient NNS cord-015306-us58wwmp 81 16 . . . cord-015306-us58wwmp 82 1 susceptibility susceptibility NNP cord-015306-us58wwmp 82 2 data datum NNS cord-015306-us58wwmp 82 3 . . . cord-015306-us58wwmp 83 1 Knowledge knowledge NN cord-015306-us58wwmp 83 2 of of IN cord-015306-us58wwmp 83 3 local local JJ cord-015306-us58wwmp 83 4 antimicrobial antimicrobial JJ cord-015306-us58wwmp 83 5 susceptibility susceptibility NN cord-015306-us58wwmp 83 6 all all DT cord-015306-us58wwmp 83 7 children child NNS cord-015306-us58wwmp 83 8 with with IN cord-015306-us58wwmp 83 9 the the DT cord-015306-us58wwmp 83 10 first first JJ cord-015306-us58wwmp 83 11 episode episode NN cord-015306-us58wwmp 83 12 of of IN cord-015306-us58wwmp 83 13 febrile febrile JJ cord-015306-us58wwmp 83 14 urinary urinary JJ cord-015306-us58wwmp 83 15 tract tract NN cord-015306-us58wwmp 83 16 infection infection NN cord-015306-us58wwmp 83 17 traditionally traditionally RB cord-015306-us58wwmp 83 18 . . . cord-015306-us58wwmp 84 1 Nowadays nowadays RB cord-015306-us58wwmp 84 2 it -PRON- PRP cord-015306-us58wwmp 84 3 has have VBZ cord-015306-us58wwmp 84 4 been be VBN cord-015306-us58wwmp 84 5 revealed reveal VBN cord-015306-us58wwmp 84 6 that that IN cord-015306-us58wwmp 84 7 the the DT cord-015306-us58wwmp 84 8 presence presence NN cord-015306-us58wwmp 84 9 of of IN cord-015306-us58wwmp 84 10 renal renal JJ cord-015306-us58wwmp 84 11 scar scar NN cord-015306-us58wwmp 84 12 is be VBZ cord-015306-us58wwmp 84 13 more more RBR cord-015306-us58wwmp 84 14 important important JJ cord-015306-us58wwmp 84 15 than than IN cord-015306-us58wwmp 84 16 the the DT cord-015306-us58wwmp 84 17 presence presence NN cord-015306-us58wwmp 84 18 of of IN cord-015306-us58wwmp 84 19 VUR VUR NNP cord-015306-us58wwmp 84 20 regarding regard VBG cord-015306-us58wwmp 84 21 renal renal JJ cord-015306-us58wwmp 84 22 and and CC cord-015306-us58wwmp 84 23 patient patient JJ cord-015306-us58wwmp 84 24 outcome outcome NN cord-015306-us58wwmp 84 25 . . . cord-015306-us58wwmp 85 1 Our -PRON- PRP$ cord-015306-us58wwmp 85 2 aim aim NN cord-015306-us58wwmp 85 3 was be VBD cord-015306-us58wwmp 85 4 to to TO cord-015306-us58wwmp 85 5 assess assess VB cord-015306-us58wwmp 85 6 the the DT cord-015306-us58wwmp 85 7 relationship relationship NN cord-015306-us58wwmp 85 8 between between IN cord-015306-us58wwmp 85 9 the the DT cord-015306-us58wwmp 85 10 severity severity NN cord-015306-us58wwmp 85 11 of of IN cord-015306-us58wwmp 85 12 VUR VUR NNP cord-015306-us58wwmp 85 13 and and CC cord-015306-us58wwmp 85 14 the the DT cord-015306-us58wwmp 85 15 severity severity NN cord-015306-us58wwmp 85 16 of of IN cord-015306-us58wwmp 85 17 DMSA DMSA NNS cord-015306-us58wwmp 85 18 scan scan JJ cord-015306-us58wwmp 85 19 changes change NNS cord-015306-us58wwmp 85 20 which which WDT cord-015306-us58wwmp 85 21 is be VBZ cord-015306-us58wwmp 85 22 performed perform VBN cord-015306-us58wwmp 85 23 in in IN cord-015306-us58wwmp 85 24 the the DT cord-015306-us58wwmp 85 25 first first JJ cord-015306-us58wwmp 85 26 week week NN cord-015306-us58wwmp 85 27 of of IN cord-015306-us58wwmp 85 28 the the DT cord-015306-us58wwmp 85 29 first first JJ cord-015306-us58wwmp 85 30 febrile febrile JJ cord-015306-us58wwmp 85 31 UTI UTI NNP cord-015306-us58wwmp 85 32 . . . cord-015306-us58wwmp 86 1 Methods method NNS cord-015306-us58wwmp 86 2 : : : cord-015306-us58wwmp 86 3 Children child NNS cord-015306-us58wwmp 86 4 with with IN cord-015306-us58wwmp 86 5 the the DT cord-015306-us58wwmp 86 6 first first JJ cord-015306-us58wwmp 86 7 febrile febrile JJ cord-015306-us58wwmp 86 8 UTI UTI NNP cord-015306-us58wwmp 86 9 who who WP cord-015306-us58wwmp 86 10 were be VBD cord-015306-us58wwmp 86 11 admitted admit VBN cord-015306-us58wwmp 86 12 in in IN cord-015306-us58wwmp 86 13 Ali Ali NNP cord-015306-us58wwmp 86 14 asghar asghar NNP cord-015306-us58wwmp 86 15 children child NNS cord-015306-us58wwmp 86 16 hospital hospital NN cord-015306-us58wwmp 86 17 were be VBD cord-015306-us58wwmp 86 18 evaluated evaluate VBN cord-015306-us58wwmp 86 19 prospectively prospectively RB cord-015306-us58wwmp 86 20 . . . cord-015306-us58wwmp 87 1 All all DT cord-015306-us58wwmp 87 2 DMSA DMSA NNS cord-015306-us58wwmp 87 3 scans scan NNS cord-015306-us58wwmp 87 4 have have VBP cord-015306-us58wwmp 87 5 been be VBN cord-015306-us58wwmp 87 6 observed observe VBN cord-015306-us58wwmp 87 7 and and CC cord-015306-us58wwmp 87 8 graded grade VBN cord-015306-us58wwmp 87 9 by by IN cord-015306-us58wwmp 87 10 our -PRON- PRP$ cord-015306-us58wwmp 87 11 nuclear nuclear JJ cord-015306-us58wwmp 87 12 medicine medicine NN cord-015306-us58wwmp 87 13 specialist specialist NN cord-015306-us58wwmp 87 14 without without IN cord-015306-us58wwmp 87 15 any any DT cord-015306-us58wwmp 87 16 knowledge knowledge NN cord-015306-us58wwmp 87 17 of of IN cord-015306-us58wwmp 87 18 presence presence NN cord-015306-us58wwmp 87 19 or or CC cord-015306-us58wwmp 87 20 absence absence NN cord-015306-us58wwmp 87 21 of of IN cord-015306-us58wwmp 87 22 VUR VUR NNP cord-015306-us58wwmp 87 23 . . . cord-015306-us58wwmp 88 1 Renal renal JJ cord-015306-us58wwmp 88 2 damages damage NNS cord-015306-us58wwmp 88 3 in in IN cord-015306-us58wwmp 88 4 DMSA DMSA NNS cord-015306-us58wwmp 88 5 scan scan JJ cord-015306-us58wwmp 88 6 were be VBD cord-015306-us58wwmp 88 7 classified classify VBN cord-015306-us58wwmp 88 8 to to IN cord-015306-us58wwmp 88 9 8 8 CD cord-015306-us58wwmp 88 10 grades grade NNS cord-015306-us58wwmp 88 11 as as IN cord-015306-us58wwmp 88 12 follows follow VBZ cord-015306-us58wwmp 88 13 : : : cord-015306-us58wwmp 89 1 Grade grade NN cord-015306-us58wwmp 89 2 0 0 CD cord-015306-us58wwmp 89 3 : : : cord-015306-us58wwmp 89 4 normal normal JJ cord-015306-us58wwmp 89 5 kidney kidney NN cord-015306-us58wwmp 89 6 , , , cord-015306-us58wwmp 89 7 grade grade NN cord-015306-us58wwmp 89 8 1 1 CD cord-015306-us58wwmp 89 9 : : : cord-015306-us58wwmp 89 10 decreased decrease VBN cord-015306-us58wwmp 89 11 uptake uptake NN cord-015306-us58wwmp 89 12 in in IN cord-015306-us58wwmp 89 13 one one CD cord-015306-us58wwmp 89 14 pole pole NN cord-015306-us58wwmp 89 15 with with IN cord-015306-us58wwmp 89 16 intact intact JJ cord-015306-us58wwmp 89 17 border border NN cord-015306-us58wwmp 89 18 , , , cord-015306-us58wwmp 89 19 grade grade NN cord-015306-us58wwmp 89 20 2 2 CD cord-015306-us58wwmp 89 21 : : : cord-015306-us58wwmp 89 22 decreased decrease VBN cord-015306-us58wwmp 89 23 uptake uptake NN cord-015306-us58wwmp 89 24 in in IN cord-015306-us58wwmp 89 25 two two CD cord-015306-us58wwmp 89 26 poles pole NNS cord-015306-us58wwmp 89 27 with with IN cord-015306-us58wwmp 89 28 intact intact JJ cord-015306-us58wwmp 89 29 borders border NNS cord-015306-us58wwmp 89 30 , , , cord-015306-us58wwmp 89 31 grade grade NN cord-015306-us58wwmp 89 32 3 3 CD cord-015306-us58wwmp 89 33 : : : cord-015306-us58wwmp 90 1 diffuse diffuse JJ cord-015306-us58wwmp 90 2 decreased decrease VBD cord-015306-us58wwmp 90 3 uptake uptake NN cord-015306-us58wwmp 90 4 with with IN cord-015306-us58wwmp 90 5 intact intact JJ cord-015306-us58wwmp 90 6 border border NN cord-015306-us58wwmp 90 7 , , , cord-015306-us58wwmp 90 8 grade grade NN cord-015306-us58wwmp 90 9 4 4 CD cord-015306-us58wwmp 90 10 : : : cord-015306-us58wwmp 90 11 decreased decrease VBN cord-015306-us58wwmp 90 12 uptake uptake NN cord-015306-us58wwmp 90 13 in in IN cord-015306-us58wwmp 90 14 one one CD cord-015306-us58wwmp 90 15 pole pole NN cord-015306-us58wwmp 90 16 with with IN cord-015306-us58wwmp 90 17 scar scar NN cord-015306-us58wwmp 90 18 , , , cord-015306-us58wwmp 90 19 grade grade NN cord-015306-us58wwmp 90 20 5 5 CD cord-015306-us58wwmp 90 21 : : : cord-015306-us58wwmp 90 22 decreased decrease VBN cord-015306-us58wwmp 90 23 uptake uptake NN cord-015306-us58wwmp 90 24 in in IN cord-015306-us58wwmp 90 25 two two CD cord-015306-us58wwmp 90 26 poles pole NNS cord-015306-us58wwmp 90 27 with with IN cord-015306-us58wwmp 90 28 scar scar NN cord-015306-us58wwmp 90 29 , , , cord-015306-us58wwmp 90 30 grade grade NN cord-015306-us58wwmp 90 31 6 6 CD cord-015306-us58wwmp 90 32 : : : cord-015306-us58wwmp 90 33 multiple multiple JJ cord-015306-us58wwmp 90 34 scars scar NNS cord-015306-us58wwmp 90 35 , , , cord-015306-us58wwmp 90 36 grade grade NN cord-015306-us58wwmp 90 37 7 7 CD cord-015306-us58wwmp 90 38 : : : cord-015306-us58wwmp 90 39 diffuse diffuse NN cord-015306-us58wwmp 90 40 decreased decreased JJ cord-015306-us58wwmp 90 41 uptake uptake NN cord-015306-us58wwmp 90 42 with with IN cord-015306-us58wwmp 90 43 one one CD cord-015306-us58wwmp 90 44 pole pole NN cord-015306-us58wwmp 90 45 scar scar NN cord-015306-us58wwmp 90 46 , , , cord-015306-us58wwmp 90 47 grade grade NN cord-015306-us58wwmp 90 48 8 8 CD cord-015306-us58wwmp 90 49 : : : cord-015306-us58wwmp 90 50 diffuse diffuse VB cord-015306-us58wwmp 91 1 decreased decrease VBN cord-015306-us58wwmp 91 2 uptake uptake NN cord-015306-us58wwmp 91 3 with with IN cord-015306-us58wwmp 91 4 multiple multiple JJ cord-015306-us58wwmp 91 5 scars scar NNS cord-015306-us58wwmp 91 6 . . . cord-015306-us58wwmp 92 1 Then then RB cord-015306-us58wwmp 92 2 DMSA DMSA NNP cord-015306-us58wwmp 92 3 findings finding NNS cord-015306-us58wwmp 92 4 in in IN cord-015306-us58wwmp 92 5 patients patient NNS cord-015306-us58wwmp 92 6 with with IN cord-015306-us58wwmp 92 7 no no DT cord-015306-us58wwmp 92 8 VUR VUR NNP cord-015306-us58wwmp 92 9 , , , cord-015306-us58wwmp 92 10 with with IN cord-015306-us58wwmp 92 11 low low JJ cord-015306-us58wwmp 92 12 grade grade NN cord-015306-us58wwmp 92 13 VUR VUR NNP cord-015306-us58wwmp 92 14 and and CC cord-015306-us58wwmp 92 15 high high JJ cord-015306-us58wwmp 92 16 grade grade NN cord-015306-us58wwmp 92 17 or or CC cord-015306-us58wwmp 92 18 dilating dilate VBG cord-015306-us58wwmp 92 19 VUR VUR NNP cord-015306-us58wwmp 92 20 were be VBD cord-015306-us58wwmp 92 21 compared compare VBN cord-015306-us58wwmp 92 22 with with IN cord-015306-us58wwmp 92 23 each each DT cord-015306-us58wwmp 92 24 other other JJ cord-015306-us58wwmp 92 25 . . . cord-015306-us58wwmp 93 1 Results result NNS cord-015306-us58wwmp 93 2 and and CC cord-015306-us58wwmp 93 3 Conclusion conclusion NN cord-015306-us58wwmp 93 4 : : : cord-015306-us58wwmp 93 5 One one CD cord-015306-us58wwmp 93 6 hundred hundred CD cord-015306-us58wwmp 93 7 and and CC cord-015306-us58wwmp 93 8 six six CD cord-015306-us58wwmp 93 9 patients patient NNS cord-015306-us58wwmp 93 10 with with IN cord-015306-us58wwmp 93 11 the the DT cord-015306-us58wwmp 93 12 first first JJ cord-015306-us58wwmp 93 13 febrile febrile JJ cord-015306-us58wwmp 93 14 UTI UTI NNP cord-015306-us58wwmp 93 15 were be VBD cord-015306-us58wwmp 93 16 included include VBN cord-015306-us58wwmp 93 17 in in IN cord-015306-us58wwmp 93 18 this this DT cord-015306-us58wwmp 93 19 study study NN cord-015306-us58wwmp 93 20 , , , cord-015306-us58wwmp 93 21 thus thus RB cord-015306-us58wwmp 93 22 212 212 CD cord-015306-us58wwmp 93 23 kidneys kidney NNS cord-015306-us58wwmp 93 24 were be VBD cord-015306-us58wwmp 93 25 evaluated evaluate VBN cord-015306-us58wwmp 93 26 for for IN cord-015306-us58wwmp 93 27 the the DT cord-015306-us58wwmp 93 28 presence presence NN cord-015306-us58wwmp 93 29 or or CC cord-015306-us58wwmp 93 30 absence absence NN cord-015306-us58wwmp 93 31 of of IN cord-015306-us58wwmp 93 32 VUR VUR NNP cord-015306-us58wwmp 93 33 and and CC cord-015306-us58wwmp 93 34 DMSA DMSA NNP cord-015306-us58wwmp 93 35 grading grading NN cord-015306-us58wwmp 93 36 . . . cord-015306-us58wwmp 94 1 The the DT cord-015306-us58wwmp 94 2 mean mean JJ cord-015306-us58wwmp 94 3 age age NN cord-015306-us58wwmp 94 4 of of IN cord-015306-us58wwmp 94 5 our -PRON- PRP$ cord-015306-us58wwmp 94 6 patients patient NNS cord-015306-us58wwmp 94 7 was be VBD cord-015306-us58wwmp 94 8 4±2.9 4±2.9 CD cord-015306-us58wwmp 94 9 years year NNS cord-015306-us58wwmp 94 10 old old JJ cord-015306-us58wwmp 94 11 . . . cord-015306-us58wwmp 95 1 12.3 12.3 CD cord-015306-us58wwmp 95 2 % % NN cord-015306-us58wwmp 95 3 of of IN cord-015306-us58wwmp 95 4 our -PRON- PRP$ cord-015306-us58wwmp 95 5 patients patient NNS cord-015306-us58wwmp 95 6 were be VBD cord-015306-us58wwmp 95 7 male male JJ cord-015306-us58wwmp 95 8 . . . cord-015306-us58wwmp 96 1 44.8 44.8 CD cord-015306-us58wwmp 96 2 % % NN cord-015306-us58wwmp 96 3 of of IN cord-015306-us58wwmp 96 4 kidneys kidney NNS cord-015306-us58wwmp 96 5 did do VBD cord-015306-us58wwmp 96 6 not not RB cord-015306-us58wwmp 96 7 have have VB cord-015306-us58wwmp 96 8 any any DT cord-015306-us58wwmp 96 9 VUR VUR NNP cord-015306-us58wwmp 96 10 , , , cord-015306-us58wwmp 96 11 low low JJ cord-015306-us58wwmp 96 12 grade grade NN cord-015306-us58wwmp 96 13 VUR VUR NNP cord-015306-us58wwmp 96 14 ( ( -LRB- cord-015306-us58wwmp 96 15 grades grade NNS cord-015306-us58wwmp 96 16 1,2,3 1,2,3 CD cord-015306-us58wwmp 96 17 ) ) -RRB- cord-015306-us58wwmp 96 18 was be VBD cord-015306-us58wwmp 96 19 seen see VBN cord-015306-us58wwmp 96 20 in in IN cord-015306-us58wwmp 96 21 34.4 34.4 CD cord-015306-us58wwmp 96 22 % % NN cord-015306-us58wwmp 96 23 of of IN cord-015306-us58wwmp 96 24 kidneys kidney NNS cord-015306-us58wwmp 96 25 and and CC cord-015306-us58wwmp 96 26 high high JJ cord-015306-us58wwmp 96 27 grade grade NN cord-015306-us58wwmp 96 28 VUR VUR NNP cord-015306-us58wwmp 96 29 9grades 9grades CD cord-015306-us58wwmp 96 30 4 4 CD cord-015306-us58wwmp 96 31 , , , cord-015306-us58wwmp 96 32 5 5 CD cord-015306-us58wwmp 96 33 ) ) -RRB- cord-015306-us58wwmp 96 34 was be VBD cord-015306-us58wwmp 96 35 found find VBN cord-015306-us58wwmp 96 36 in in IN cord-015306-us58wwmp 96 37 20.3 20.3 CD cord-015306-us58wwmp 96 38 % % NN cord-015306-us58wwmp 96 39 of of IN cord-015306-us58wwmp 96 40 kidneys kidney NNS cord-015306-us58wwmp 96 41 . . . cord-015306-us58wwmp 97 1 76.2 76.2 CD cord-015306-us58wwmp 97 2 % % NN cord-015306-us58wwmp 97 3 of of IN cord-015306-us58wwmp 97 4 patients patient NNS cord-015306-us58wwmp 97 5 with with IN cord-015306-us58wwmp 97 6 low low JJ cord-015306-us58wwmp 97 7 grade grade NN cord-015306-us58wwmp 97 8 VUR VUR NNP cord-015306-us58wwmp 97 9 and/or and/or CC cord-015306-us58wwmp 97 10 without without IN cord-015306-us58wwmp 97 11 VUR VUR NNP cord-015306-us58wwmp 97 12 had have VBD cord-015306-us58wwmp 97 13 DMSA DMSA NNS cord-015306-us58wwmp 97 14 scoring score VBG cord-015306-us58wwmp 97 15 . . . cord-015306-us58wwmp 98 1 Abstract abstract JJ cord-015306-us58wwmp 98 2 # # NN cord-015306-us58wwmp 99 1 P P NNP cord-015306-us58wwmp 99 2 - - HYPH cord-015306-us58wwmp 99 3 SAT040 SAT040 NNP cord-015306-us58wwmp 99 4 Fibronection Fibronection NNP cord-015306-us58wwmp 99 5 in in IN cord-015306-us58wwmp 99 6 reflux reflux NN cord-015306-us58wwmp 99 7 nephropathy nephropathy NN cord-015306-us58wwmp 99 8 , , , cord-015306-us58wwmp 99 9 is be VBZ cord-015306-us58wwmp 99 10 it -PRON- PRP cord-015306-us58wwmp 99 11 a a DT cord-015306-us58wwmp 99 12 marker marker NN cord-015306-us58wwmp 99 13 of of IN cord-015306-us58wwmp 99 14 grade grade NN cord-015306-us58wwmp 99 15 of of IN cord-015306-us58wwmp 99 16 reflux reflux NN cord-015306-us58wwmp 99 17 ? ? . cord-015306-us58wwmp 100 1 Nahid Nahid NNP cord-015306-us58wwmp 100 2 rahimzadeh rahimzadeh VBD cord-015306-us58wwmp 100 3 Tehran Tehran NNP cord-015306-us58wwmp 100 4 university university NNP cord-015306-us58wwmp 100 5 of of IN cord-015306-us58wwmp 100 6 medical medical JJ cord-015306-us58wwmp 100 7 science science NN cord-015306-us58wwmp 100 8 , , , cord-015306-us58wwmp 100 9 associated associated JJ cord-015306-us58wwmp 100 10 professor professor NN cord-015306-us58wwmp 100 11 , , , cord-015306-us58wwmp 100 12 Tehran Tehran NNP cord-015306-us58wwmp 100 13 , , , cord-015306-us58wwmp 101 1 Iran Iran NNP cord-015306-us58wwmp 101 2 Objective Objective NNP cord-015306-us58wwmp 101 3 : : : cord-015306-us58wwmp 101 4 Vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 101 5 reflux reflux NN cord-015306-us58wwmp 101 6 ( ( -LRB- cord-015306-us58wwmp 101 7 VUR VUR NNP cord-015306-us58wwmp 101 8 ) ) -RRB- cord-015306-us58wwmp 101 9 is be VBZ cord-015306-us58wwmp 101 10 one one CD cord-015306-us58wwmp 101 11 of of IN cord-015306-us58wwmp 101 12 the the DT cord-015306-us58wwmp 101 13 most most RBS cord-015306-us58wwmp 101 14 common common JJ cord-015306-us58wwmp 101 15 urinary urinary JJ cord-015306-us58wwmp 101 16 tract tract JJ cord-015306-us58wwmp 101 17 abnormalities abnormality NNS cord-015306-us58wwmp 101 18 in in IN cord-015306-us58wwmp 101 19 patients patient NNS cord-015306-us58wwmp 101 20 with with IN cord-015306-us58wwmp 101 21 urinary urinary JJ cord-015306-us58wwmp 101 22 tract tract NN cord-015306-us58wwmp 101 23 infection infection NN cord-015306-us58wwmp 101 24 . . . cord-015306-us58wwmp 102 1 Nowadays nowadays RB cord-015306-us58wwmp 102 2 noninvasive noninvasive JJ cord-015306-us58wwmp 102 3 diagnostic diagnostic JJ cord-015306-us58wwmp 102 4 methods method NNS cord-015306-us58wwmp 102 5 are be VBP cord-015306-us58wwmp 102 6 suggested suggest VBN cord-015306-us58wwmp 102 7 to to TO cord-015306-us58wwmp 102 8 recognize recognize VB cord-015306-us58wwmp 102 9 VUR VUR NNP cord-015306-us58wwmp 102 10 and and CC cord-015306-us58wwmp 102 11 its -PRON- PRP$ cord-015306-us58wwmp 102 12 severity severity NN cord-015306-us58wwmp 102 13 . . . cord-015306-us58wwmp 103 1 Methods method NNS cord-015306-us58wwmp 103 2 : : : cord-015306-us58wwmp 104 1 We -PRON- PRP cord-015306-us58wwmp 104 2 measured measure VBD cord-015306-us58wwmp 104 3 urinary urinary JJ cord-015306-us58wwmp 104 4 and and CC cord-015306-us58wwmp 104 5 serum serum NN cord-015306-us58wwmp 104 6 fibronectin fibronectin NN cord-015306-us58wwmp 104 7 in in IN cord-015306-us58wwmp 104 8 51 51 CD cord-015306-us58wwmp 104 9 children child NNS cord-015306-us58wwmp 104 10 with with IN cord-015306-us58wwmp 104 11 VUR VUR NNP cord-015306-us58wwmp 104 12 . . . cord-015306-us58wwmp 105 1 Results result NNS cord-015306-us58wwmp 105 2 : : : cord-015306-us58wwmp 106 1 The the DT cord-015306-us58wwmp 106 2 mean mean JJ cord-015306-us58wwmp 106 3 serum serum NN cord-015306-us58wwmp 106 4 fibronectin fibronectin NN cord-015306-us58wwmp 106 5 was be VBD cord-015306-us58wwmp 106 6 318.3±112.1 318.3±112.1 CD cord-015306-us58wwmp 106 7 in in IN cord-015306-us58wwmp 106 8 children child NNS cord-015306-us58wwmp 106 9 with with IN cord-015306-us58wwmp 106 10 low low JJ cord-015306-us58wwmp 106 11 grade grade NN cord-015306-us58wwmp 106 12 VUR VUR NNP cord-015306-us58wwmp 106 13 versus versus IN cord-015306-us58wwmp 106 14 356.1±189.9 356.1±189.9 CD cord-015306-us58wwmp 106 15 in in IN cord-015306-us58wwmp 106 16 children child NNS cord-015306-us58wwmp 106 17 with with IN cord-015306-us58wwmp 106 18 high high JJ cord-015306-us58wwmp 106 19 grade grade NN cord-015306-us58wwmp 106 20 VUR VUR NNP cord-015306-us58wwmp 106 21 ( ( -LRB- cord-015306-us58wwmp 106 22 Pv>0.05 Pv>0.05 NNP cord-015306-us58wwmp 106 23 ) ) -RRB- cord-015306-us58wwmp 106 24 . . . cord-015306-us58wwmp 107 1 The the DT cord-015306-us58wwmp 107 2 mean mean JJ cord-015306-us58wwmp 107 3 urinary urinary JJ cord-015306-us58wwmp 107 4 fibronectin fibronectin NN cord-015306-us58wwmp 107 5 was be VBD cord-015306-us58wwmp 107 6 also also RB cord-015306-us58wwmp 107 7 31.5±12.9 31.5±12.9 CD cord-015306-us58wwmp 107 8 in in IN cord-015306-us58wwmp 107 9 low low JJ cord-015306-us58wwmp 107 10 grade grade NN cord-015306-us58wwmp 107 11 VUR VUR NNP cord-015306-us58wwmp 107 12 and and CC cord-015306-us58wwmp 107 13 25.9±14.2 25.9±14.2 CD cord-015306-us58wwmp 107 14 in in IN cord-015306-us58wwmp 107 15 high high JJ cord-015306-us58wwmp 107 16 grade grade NN cord-015306-us58wwmp 107 17 VUR VUR NNP cord-015306-us58wwmp 107 18 ( ( -LRB- cord-015306-us58wwmp 107 19 Pv>0.05 Pv>0.05 NNP cord-015306-us58wwmp 107 20 ) ) -RRB- cord-015306-us58wwmp 107 21 . . . cord-015306-us58wwmp 108 1 Thus thus RB cord-015306-us58wwmp 108 2 we -PRON- PRP cord-015306-us58wwmp 108 3 did do VBD cord-015306-us58wwmp 108 4 n't not RB cord-015306-us58wwmp 108 5 find find VB cord-015306-us58wwmp 108 6 any any DT cord-015306-us58wwmp 108 7 association association NN cord-015306-us58wwmp 108 8 between between IN cord-015306-us58wwmp 108 9 the the DT cord-015306-us58wwmp 108 10 severity severity NN cord-015306-us58wwmp 108 11 of of IN cord-015306-us58wwmp 108 12 VUR VUR NNP cord-015306-us58wwmp 108 13 and and CC cord-015306-us58wwmp 108 14 the the DT cord-015306-us58wwmp 108 15 amount amount NN cord-015306-us58wwmp 108 16 of of IN cord-015306-us58wwmp 108 17 fibronectin fibronectin NN cord-015306-us58wwmp 108 18 in in IN cord-015306-us58wwmp 108 19 serum serum NN cord-015306-us58wwmp 108 20 and and CC cord-015306-us58wwmp 108 21 urine urine NN cord-015306-us58wwmp 108 22 of of IN cord-015306-us58wwmp 108 23 patients patient NNS cord-015306-us58wwmp 108 24 . . . cord-015306-us58wwmp 109 1 We -PRON- PRP cord-015306-us58wwmp 109 2 also also RB cord-015306-us58wwmp 109 3 did do VBD cord-015306-us58wwmp 109 4 n't not RB cord-015306-us58wwmp 109 5 find find VB cord-015306-us58wwmp 109 6 any any DT cord-015306-us58wwmp 109 7 relationship relationship NN cord-015306-us58wwmp 109 8 between between IN cord-015306-us58wwmp 109 9 DMSA DMSA NNS cord-015306-us58wwmp 109 10 changes change NNS cord-015306-us58wwmp 109 11 at at IN cord-015306-us58wwmp 109 12 the the DT cord-015306-us58wwmp 109 13 acute acute JJ cord-015306-us58wwmp 109 14 phase phase NN cord-015306-us58wwmp 109 15 of of IN cord-015306-us58wwmp 109 16 UTI UTI NNP cord-015306-us58wwmp 109 17 and and CC cord-015306-us58wwmp 109 18 serum serum NN cord-015306-us58wwmp 109 19 and and CC cord-015306-us58wwmp 109 20 urine urine NN cord-015306-us58wwmp 109 21 fibronectin fibronectin NN cord-015306-us58wwmp 109 22 . . . cord-015306-us58wwmp 110 1 Conclusion conclusion NN cord-015306-us58wwmp 110 2 : : : cord-015306-us58wwmp 111 1 In in IN cord-015306-us58wwmp 111 2 contrast contrast NN cord-015306-us58wwmp 111 3 to to IN cord-015306-us58wwmp 111 4 some some DT cord-015306-us58wwmp 111 5 previous previous JJ cord-015306-us58wwmp 111 6 studies study NNS cord-015306-us58wwmp 111 7 , , , cord-015306-us58wwmp 111 8 we -PRON- PRP cord-015306-us58wwmp 111 9 showed show VBD cord-015306-us58wwmp 111 10 the the DT cord-015306-us58wwmp 111 11 serum serum NN cord-015306-us58wwmp 111 12 and and CC cord-015306-us58wwmp 111 13 urinary urinary JJ cord-015306-us58wwmp 111 14 fibronectin fibronectin NN cord-015306-us58wwmp 111 15 can can MD cord-015306-us58wwmp 111 16 not not RB cord-015306-us58wwmp 111 17 preclude preclude VB cord-015306-us58wwmp 111 18 the the DT cord-015306-us58wwmp 111 19 severity severity NN cord-015306-us58wwmp 111 20 and and CC cord-015306-us58wwmp 111 21 grade grade NN cord-015306-us58wwmp 111 22 of of IN cord-015306-us58wwmp 111 23 VUR VUR NNP cord-015306-us58wwmp 111 24 and and CC cord-015306-us58wwmp 111 25 hence hence RB cord-015306-us58wwmp 111 26 it -PRON- PRP cord-015306-us58wwmp 111 27 is be VBZ cord-015306-us58wwmp 111 28 not not RB cord-015306-us58wwmp 111 29 suitable suitable JJ cord-015306-us58wwmp 111 30 surrogate surrogate JJ cord-015306-us58wwmp 111 31 marker marker NN cord-015306-us58wwmp 111 32 for for IN cord-015306-us58wwmp 111 33 imaging imaging NN cord-015306-us58wwmp 111 34 techniques technique NNS cord-015306-us58wwmp 111 35 for for IN cord-015306-us58wwmp 111 36 VUR VUR NNP cord-015306-us58wwmp 111 37 diagnosis diagnosis NN cord-015306-us58wwmp 111 38 . . . cord-015306-us58wwmp 112 1 Abstract abstract JJ cord-015306-us58wwmp 112 2 # # NN cord-015306-us58wwmp 112 3 P p NN cord-015306-us58wwmp 112 4 - - HYPH cord-015306-us58wwmp 112 5 SAT041 sat041 JJ cord-015306-us58wwmp 113 1 The the DT cord-015306-us58wwmp 113 2 use use NN cord-015306-us58wwmp 113 3 of of IN cord-015306-us58wwmp 113 4 serum serum NN cord-015306-us58wwmp 113 5 procalcitonin procalcitonin NN cord-015306-us58wwmp 113 6 level level NN cord-015306-us58wwmp 113 7 in in IN cord-015306-us58wwmp 113 8 the the DT cord-015306-us58wwmp 113 9 prediction prediction NN cord-015306-us58wwmp 113 10 of of IN cord-015306-us58wwmp 113 11 high high JJ cord-015306-us58wwmp 113 12 grade grade NN cord-015306-us58wwmp 113 13 vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 113 14 reflux reflux NN cord-015306-us58wwmp 113 15 in in IN cord-015306-us58wwmp 113 16 urinary urinary JJ cord-015306-us58wwmp 113 17 tract tract NN cord-015306-us58wwmp 113 18 infection infection NN cord-015306-us58wwmp 113 19 Nahid Nahid NNP cord-015306-us58wwmp 113 20 rahimzadeh rahimzadeh VBD cord-015306-us58wwmp 113 21 Tehran Tehran NNP cord-015306-us58wwmp 113 22 university university NNP cord-015306-us58wwmp 113 23 of of IN cord-015306-us58wwmp 113 24 medical medical JJ cord-015306-us58wwmp 113 25 science science NN cord-015306-us58wwmp 113 26 , , , cord-015306-us58wwmp 113 27 associated associated JJ cord-015306-us58wwmp 113 28 professor professor NN cord-015306-us58wwmp 113 29 , , , cord-015306-us58wwmp 113 30 Tehran Tehran NNP cord-015306-us58wwmp 113 31 , , , cord-015306-us58wwmp 114 1 Iran Iran NNP cord-015306-us58wwmp 114 2 Objective Objective NNP cord-015306-us58wwmp 114 3 : : : cord-015306-us58wwmp 115 1 Procalcitonin Procalcitonin NNP cord-015306-us58wwmp 115 2 is be VBZ cord-015306-us58wwmp 115 3 a a DT cord-015306-us58wwmp 115 4 reliable reliable JJ cord-015306-us58wwmp 115 5 and and CC cord-015306-us58wwmp 115 6 specific specific JJ cord-015306-us58wwmp 115 7 marker marker NN cord-015306-us58wwmp 115 8 of of IN cord-015306-us58wwmp 115 9 bacterial bacterial JJ cord-015306-us58wwmp 115 10 infection infection NN cord-015306-us58wwmp 115 11 such such JJ cord-015306-us58wwmp 115 12 as as IN cord-015306-us58wwmp 115 13 urinary urinary JJ cord-015306-us58wwmp 115 14 tract tract NN cord-015306-us58wwmp 115 15 infection infection NN cord-015306-us58wwmp 115 16 . . . cord-015306-us58wwmp 116 1 Some some DT cord-015306-us58wwmp 116 2 authors author NNS cord-015306-us58wwmp 116 3 suggest suggest VBP cord-015306-us58wwmp 116 4 measurement measurement NN cord-015306-us58wwmp 116 5 of of IN cord-015306-us58wwmp 116 6 serum serum NN cord-015306-us58wwmp 116 7 procalcitonin procalcitonin NNS cord-015306-us58wwmp 116 8 as as IN cord-015306-us58wwmp 116 9 a a DT cord-015306-us58wwmp 116 10 predictor predictor NN cord-015306-us58wwmp 116 11 of of IN cord-015306-us58wwmp 116 12 vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 116 13 reflux reflux NN cord-015306-us58wwmp 116 14 . . . cord-015306-us58wwmp 117 1 We -PRON- PRP cord-015306-us58wwmp 117 2 investigated investigate VBD cord-015306-us58wwmp 117 3 this this DT cord-015306-us58wwmp 117 4 association association NN cord-015306-us58wwmp 117 5 in in IN cord-015306-us58wwmp 117 6 children child NNS cord-015306-us58wwmp 117 7 who who WP cord-015306-us58wwmp 117 8 admitted admit VBD cord-015306-us58wwmp 117 9 because because IN cord-015306-us58wwmp 117 10 of of IN cord-015306-us58wwmp 117 11 acute acute JJ cord-015306-us58wwmp 117 12 pyelonephritis pyelonephritis NN cord-015306-us58wwmp 117 13 . . . cord-015306-us58wwmp 118 1 Methods method NNS cord-015306-us58wwmp 118 2 : : : cord-015306-us58wwmp 119 1 Forty forty CD cord-015306-us58wwmp 119 2 eight eight CD cord-015306-us58wwmp 119 3 children child NNS cord-015306-us58wwmp 119 4 with with IN cord-015306-us58wwmp 119 5 the the DT cord-015306-us58wwmp 119 6 first first JJ cord-015306-us58wwmp 119 7 febrile febrile JJ cord-015306-us58wwmp 119 8 UTI UTI NNP cord-015306-us58wwmp 119 9 were be VBD cord-015306-us58wwmp 119 10 included include VBN cord-015306-us58wwmp 119 11 . . . cord-015306-us58wwmp 120 1 Twelve twelve CD cord-015306-us58wwmp 120 2 patients patient NNS cord-015306-us58wwmp 120 3 had have VBD cord-015306-us58wwmp 120 4 low low JJ cord-015306-us58wwmp 120 5 grade grade NN cord-015306-us58wwmp 120 6 VUR VUR NNP cord-015306-us58wwmp 120 7 , , , cord-015306-us58wwmp 120 8 nine nine CD cord-015306-us58wwmp 120 9 patients patient NNS cord-015306-us58wwmp 120 10 had have VBD cord-015306-us58wwmp 120 11 high high JJ cord-015306-us58wwmp 120 12 grade grade NN cord-015306-us58wwmp 120 13 VUR VUR NNP cord-015306-us58wwmp 120 14 ( ( -LRB- cord-015306-us58wwmp 120 15 ( ( -LRB- cord-015306-us58wwmp 120 16 ≥ ≥ CD cord-015306-us58wwmp 120 17 3 3 CD cord-015306-us58wwmp 120 18 ) ) -RRB- cord-015306-us58wwmp 120 19 and and CC cord-015306-us58wwmp 120 20 twenty twenty CD cord-015306-us58wwmp 120 21 seven seven CD cord-015306-us58wwmp 120 22 patients patient NNS cord-015306-us58wwmp 120 23 did do VBD cord-015306-us58wwmp 120 24 n't not RB cord-015306-us58wwmp 120 25 have have VB cord-015306-us58wwmp 120 26 any any DT cord-015306-us58wwmp 120 27 VUR VUR NNP cord-015306-us58wwmp 120 28 in in IN cord-015306-us58wwmp 120 29 their -PRON- PRP$ cord-015306-us58wwmp 120 30 imaging imaging NN cord-015306-us58wwmp 120 31 assessment assessment NN cord-015306-us58wwmp 120 32 . . . cord-015306-us58wwmp 121 1 Results result NNS cord-015306-us58wwmp 121 2 : : : cord-015306-us58wwmp 122 1 There there EX cord-015306-us58wwmp 122 2 was be VBD cord-015306-us58wwmp 122 3 a a DT cord-015306-us58wwmp 122 4 significant significant JJ cord-015306-us58wwmp 122 5 association association NN cord-015306-us58wwmp 122 6 between between IN cord-015306-us58wwmp 122 7 high high JJ cord-015306-us58wwmp 122 8 grade grade NN cord-015306-us58wwmp 122 9 VUR VUR NNP cord-015306-us58wwmp 122 10 and and CC cord-015306-us58wwmp 122 11 higher high JJR cord-015306-us58wwmp 122 12 levels level NNS cord-015306-us58wwmp 122 13 of of IN cord-015306-us58wwmp 122 14 procalcitonin procalcitonin NNS cord-015306-us58wwmp 122 15 ( ( -LRB- cord-015306-us58wwmp 122 16 Pv=0.04 pv=0.04 NN cord-015306-us58wwmp 122 17 ) ) -RRB- cord-015306-us58wwmp 122 18 . . . cord-015306-us58wwmp 123 1 The the DT cord-015306-us58wwmp 123 2 sensitivity sensitivity NN cord-015306-us58wwmp 123 3 of of IN cord-015306-us58wwmp 123 4 procalcitonin procalcitonin JJ cord-015306-us58wwmp 123 5 level level NN cord-015306-us58wwmp 123 6 ≥ ≥ CD cord-015306-us58wwmp 123 7 0.31 0.31 CD cord-015306-us58wwmp 123 8 ng ng NNP cord-015306-us58wwmp 123 9 / / SYM cord-015306-us58wwmp 123 10 ml ml NN cord-015306-us58wwmp 123 11 was be VBD cord-015306-us58wwmp 123 12 90 90 CD cord-015306-us58wwmp 123 13 % % NN cord-015306-us58wwmp 123 14 and and CC cord-015306-us58wwmp 123 15 specificity specificity NN cord-015306-us58wwmp 123 16 was be VBD cord-015306-us58wwmp 123 17 32 32 CD cord-015306-us58wwmp 123 18 % % NN cord-015306-us58wwmp 123 19 for for IN cord-015306-us58wwmp 123 20 diagnosis diagnosis NN cord-015306-us58wwmp 123 21 of of IN cord-015306-us58wwmp 123 22 high high JJ cord-015306-us58wwmp 123 23 grade grade NN cord-015306-us58wwmp 123 24 VUR VUR NNP cord-015306-us58wwmp 123 25 . . . cord-015306-us58wwmp 124 1 Conclusion conclusion NN cord-015306-us58wwmp 124 2 : : : cord-015306-us58wwmp 125 1 We -PRON- PRP cord-015306-us58wwmp 125 2 concluded conclude VBD cord-015306-us58wwmp 125 3 that that IN cord-015306-us58wwmp 125 4 serum serum NN cord-015306-us58wwmp 125 5 procalcitonin procalcitonin NN cord-015306-us58wwmp 125 6 concentration concentration NN cord-015306-us58wwmp 125 7 is be VBZ cord-015306-us58wwmp 125 8 a a DT cord-015306-us58wwmp 125 9 sensitive sensitive JJ cord-015306-us58wwmp 125 10 and and CC cord-015306-us58wwmp 125 11 promising promising JJ cord-015306-us58wwmp 125 12 predictor predictor NN cord-015306-us58wwmp 125 13 of of IN cord-015306-us58wwmp 125 14 high high JJ cord-015306-us58wwmp 125 15 grade grade NN cord-015306-us58wwmp 125 16 vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 125 17 reflux reflux NN cord-015306-us58wwmp 125 18 . . . cord-015306-us58wwmp 126 1 hydronephrosis hydronephrosis NN cord-015306-us58wwmp 126 2 , , , cord-015306-us58wwmp 126 3 parenchymal parenchymal JJ cord-015306-us58wwmp 126 4 scarring scarring NN cord-015306-us58wwmp 126 5 and and CC cord-015306-us58wwmp 126 6 to to TO cord-015306-us58wwmp 126 7 study study VB cord-015306-us58wwmp 126 8 the the DT cord-015306-us58wwmp 126 9 rate rate NN cord-015306-us58wwmp 126 10 of of IN cord-015306-us58wwmp 126 11 resolution resolution NN cord-015306-us58wwmp 126 12 of of IN cord-015306-us58wwmp 126 13 VUR VUR NNP cord-015306-us58wwmp 126 14 on on IN cord-015306-us58wwmp 126 15 follow follow NN cord-015306-us58wwmp 126 16 up up RP cord-015306-us58wwmp 126 17 . . . cord-015306-us58wwmp 127 1 Methods method NNS cord-015306-us58wwmp 127 2 : : : cord-015306-us58wwmp 127 3 This this DT cord-015306-us58wwmp 127 4 was be VBD cord-015306-us58wwmp 127 5 a a DT cord-015306-us58wwmp 127 6 retrospective retrospective JJ cord-015306-us58wwmp 127 7 study study NN cord-015306-us58wwmp 127 8 conducted conduct VBN cord-015306-us58wwmp 127 9 by by IN cord-015306-us58wwmp 127 10 reviewing review VBG cord-015306-us58wwmp 127 11 case case NN cord-015306-us58wwmp 127 12 records record NNS cord-015306-us58wwmp 127 13 of of IN cord-015306-us58wwmp 127 14 all all DT cord-015306-us58wwmp 127 15 infants infant NNS cord-015306-us58wwmp 127 16 and and CC cord-015306-us58wwmp 127 17 children child NNS cord-015306-us58wwmp 127 18 with with IN cord-015306-us58wwmp 127 19 primary primary JJ cord-015306-us58wwmp 127 20 VUR VUR NNP cord-015306-us58wwmp 127 21 who who WP cord-015306-us58wwmp 127 22 had have VBD cord-015306-us58wwmp 127 23 minimum minimum NN cord-015306-us58wwmp 127 24 follow follow NN cord-015306-us58wwmp 127 25 up up IN cord-015306-us58wwmp 127 26 of of IN cord-015306-us58wwmp 127 27 3 3 CD cord-015306-us58wwmp 127 28 years year NNS cord-015306-us58wwmp 127 29 , , , cord-015306-us58wwmp 127 30 at at IN cord-015306-us58wwmp 127 31 our -PRON- PRP$ cord-015306-us58wwmp 127 32 nephro nephro NNP cord-015306-us58wwmp 127 33 - - HYPH cord-015306-us58wwmp 127 34 urology urology NN cord-015306-us58wwmp 127 35 clinic clinic NN cord-015306-us58wwmp 127 36 over over IN cord-015306-us58wwmp 127 37 the the DT cord-015306-us58wwmp 127 38 last last JJ cord-015306-us58wwmp 127 39 10years 10year NNS cord-015306-us58wwmp 127 40 . . . cord-015306-us58wwmp 128 1 The the DT cord-015306-us58wwmp 128 2 imaging imaging NN cord-015306-us58wwmp 128 3 evaluation evaluation NN cord-015306-us58wwmp 128 4 ( ( -LRB- cord-015306-us58wwmp 128 5 Renal Renal NNP cord-015306-us58wwmp 128 6 Ultrasound Ultrasound NNP cord-015306-us58wwmp 128 7 , , , cord-015306-us58wwmp 128 8 Voiding void VBG cord-015306-us58wwmp 128 9 cystourethrogram cystourethrogram NN cord-015306-us58wwmp 128 10 , , , cord-015306-us58wwmp 128 11 DMSA DMSA NNP cord-015306-us58wwmp 128 12 scan scan NNP cord-015306-us58wwmp 128 13 ) ) -RRB- cord-015306-us58wwmp 128 14 was be VBD cord-015306-us58wwmp 128 15 done do VBN cord-015306-us58wwmp 128 16 based base VBN cord-015306-us58wwmp 128 17 on on IN cord-015306-us58wwmp 128 18 the the DT cord-015306-us58wwmp 128 19 Indian Indian NNP cord-015306-us58wwmp 128 20 Society Society NNP cord-015306-us58wwmp 128 21 of of IN cord-015306-us58wwmp 128 22 Pediatric Pediatric NNP cord-015306-us58wwmp 128 23 Nephrology Nephrology NNP cord-015306-us58wwmp 128 24 guidelines guideline NNS cord-015306-us58wwmp 128 25 . . . cord-015306-us58wwmp 129 1 Severity severity NN cord-015306-us58wwmp 129 2 of of IN cord-015306-us58wwmp 129 3 VUR VUR NNP cord-015306-us58wwmp 129 4 was be VBD cord-015306-us58wwmp 129 5 classified classify VBN cord-015306-us58wwmp 129 6 as as IN cord-015306-us58wwmp 129 7 mild mild JJ cord-015306-us58wwmp 129 8 ( ( -LRB- cord-015306-us58wwmp 129 9 grade grade NN cord-015306-us58wwmp 129 10 I i NN cord-015306-us58wwmp 129 11 , , , cord-015306-us58wwmp 129 12 II II NNP cord-015306-us58wwmp 129 13 ) ) -RRB- cord-015306-us58wwmp 129 14 , , , cord-015306-us58wwmp 129 15 moderate moderate JJ cord-015306-us58wwmp 129 16 ( ( -LRB- cord-015306-us58wwmp 129 17 grade grade NN cord-015306-us58wwmp 129 18 II II NNP cord-015306-us58wwmp 129 19 , , , cord-015306-us58wwmp 129 20 III III NNP cord-015306-us58wwmp 129 21 ) ) -RRB- cord-015306-us58wwmp 129 22 and and CC cord-015306-us58wwmp 129 23 severe severe JJ cord-015306-us58wwmp 129 24 ( ( -LRB- cord-015306-us58wwmp 129 25 grade grade NN cord-015306-us58wwmp 129 26 V v NN cord-015306-us58wwmp 129 27 ) ) -RRB- cord-015306-us58wwmp 129 28 Results result NNS cord-015306-us58wwmp 129 29 : : : cord-015306-us58wwmp 130 1 Of of IN cord-015306-us58wwmp 130 2 the the DT cord-015306-us58wwmp 130 3 218 218 CD cord-015306-us58wwmp 130 4 children child NNS cord-015306-us58wwmp 130 5 screened screen VBN cord-015306-us58wwmp 130 6 for for IN cord-015306-us58wwmp 130 7 primary primary JJ cord-015306-us58wwmp 130 8 VUR VUR NNP cord-015306-us58wwmp 130 9 , , , cord-015306-us58wwmp 130 10 107 107 CD cord-015306-us58wwmp 130 11 with with IN cord-015306-us58wwmp 130 12 complete complete JJ cord-015306-us58wwmp 130 13 data datum NNS cord-015306-us58wwmp 130 14 were be VBD cord-015306-us58wwmp 130 15 included include VBN cord-015306-us58wwmp 130 16 for for IN cord-015306-us58wwmp 130 17 analysis analysis NN cord-015306-us58wwmp 130 18 . . . cord-015306-us58wwmp 131 1 The the DT cord-015306-us58wwmp 131 2 mean mean JJ cord-015306-us58wwmp 131 3 age age NN cord-015306-us58wwmp 131 4 was be VBD cord-015306-us58wwmp 131 5 25.68 25.68 CD cord-015306-us58wwmp 131 6 ±22.45 ±22.45 CD cord-015306-us58wwmp 131 7 months month NNS cord-015306-us58wwmp 131 8 with with IN cord-015306-us58wwmp 131 9 male male NN cord-015306-us58wwmp 131 10 to to IN cord-015306-us58wwmp 131 11 female female JJ cord-015306-us58wwmp 131 12 ratio ratio NN cord-015306-us58wwmp 131 13 of of IN cord-015306-us58wwmp 131 14 1.4:1 1.4:1 CD cord-015306-us58wwmp 131 15 . . . cord-015306-us58wwmp 132 1 The the DT cord-015306-us58wwmp 132 2 age age NN cord-015306-us58wwmp 132 3 at at IN cord-015306-us58wwmp 132 4 presentation presentation NN cord-015306-us58wwmp 132 5 was be VBD cord-015306-us58wwmp 132 6 significantly significantly RB cord-015306-us58wwmp 132 7 lower low JJR cord-015306-us58wwmp 132 8 for for IN cord-015306-us58wwmp 132 9 moderate moderate JJ cord-015306-us58wwmp 132 10 to to TO cord-015306-us58wwmp 132 11 severe severe JJ cord-015306-us58wwmp 132 12 VUR VUR NNP cord-015306-us58wwmp 132 13 as as IN cord-015306-us58wwmp 132 14 compared compare VBN cord-015306-us58wwmp 132 15 to to IN cord-015306-us58wwmp 132 16 mild mild JJ cord-015306-us58wwmp 132 17 VUR VUR NNP cord-015306-us58wwmp 132 18 ( ( -LRB- cord-015306-us58wwmp 132 19 p=0.033 p=0.033 NNP cord-015306-us58wwmp 132 20 ) ) -RRB- cord-015306-us58wwmp 132 21 . . . cord-015306-us58wwmp 133 1 Thirty thirty CD cord-015306-us58wwmp 133 2 children child NNS cord-015306-us58wwmp 133 3 ( ( -LRB- cord-015306-us58wwmp 133 4 28 28 CD cord-015306-us58wwmp 133 5 % % NN cord-015306-us58wwmp 133 6 ) ) -RRB- cord-015306-us58wwmp 133 7 had have VBD cord-015306-us58wwmp 133 8 abnormal abnormal JJ cord-015306-us58wwmp 133 9 antenatal antenatal JJ cord-015306-us58wwmp 133 10 scans scan NNS cord-015306-us58wwmp 133 11 . . . cord-015306-us58wwmp 134 1 Majorities majority NNS cord-015306-us58wwmp 134 2 ( ( -LRB- cord-015306-us58wwmp 134 3 80 80 CD cord-015306-us58wwmp 134 4 % % NN cord-015306-us58wwmp 134 5 ) ) -RRB- cord-015306-us58wwmp 134 6 of of IN cord-015306-us58wwmp 134 7 children child NNS cord-015306-us58wwmp 134 8 were be VBD cord-015306-us58wwmp 134 9 diagnosed diagnose VBN cord-015306-us58wwmp 134 10 to to TO cord-015306-us58wwmp 134 11 have have VB cord-015306-us58wwmp 134 12 VUR VUR NNP cord-015306-us58wwmp 134 13 during during IN cord-015306-us58wwmp 134 14 evaluation evaluation NN cord-015306-us58wwmp 134 15 for for IN cord-015306-us58wwmp 134 16 urinary urinary JJ cord-015306-us58wwmp 134 17 tract tract NN cord-015306-us58wwmp 134 18 infection infection NN cord-015306-us58wwmp 134 19 . . . cord-015306-us58wwmp 135 1 Among107 Among107 NNP cord-015306-us58wwmp 135 2 patients patient NNS cord-015306-us58wwmp 135 3 , , , cord-015306-us58wwmp 135 4 six six CD cord-015306-us58wwmp 135 5 had have VBD cord-015306-us58wwmp 135 6 solitary solitary JJ cord-015306-us58wwmp 135 7 kidneys kidney NNS cord-015306-us58wwmp 135 8 and and CC cord-015306-us58wwmp 135 9 thus thus RB cord-015306-us58wwmp 135 10 the the DT cord-015306-us58wwmp 135 11 total total JJ cord-015306-us58wwmp 135 12 number number NN cord-015306-us58wwmp 135 13 of of IN cord-015306-us58wwmp 135 14 systems system NNS cord-015306-us58wwmp 135 15 evaluated evaluate VBN cord-015306-us58wwmp 135 16 was be VBD cord-015306-us58wwmp 135 17 208 208 CD cord-015306-us58wwmp 135 18 . . . cord-015306-us58wwmp 136 1 Of of IN cord-015306-us58wwmp 136 2 these these DT cord-015306-us58wwmp 136 3 , , , cord-015306-us58wwmp 136 4 164 164 CD cord-015306-us58wwmp 136 5 systems system NNS cord-015306-us58wwmp 136 6 had have VBD cord-015306-us58wwmp 136 7 VUR VUR NNP cord-015306-us58wwmp 136 8 ( ( -LRB- cord-015306-us58wwmp 136 9 24 24 CD cord-015306-us58wwmp 136 10 % % NN cord-015306-us58wwmp 136 11 had have VBD cord-015306-us58wwmp 136 12 mild mild JJ cord-015306-us58wwmp 136 13 , , , cord-015306-us58wwmp 136 14 66 66 CD cord-015306-us58wwmp 136 15 % % NN cord-015306-us58wwmp 136 16 had have VBD cord-015306-us58wwmp 136 17 moderate moderate JJ cord-015306-us58wwmp 136 18 and and CC cord-015306-us58wwmp 136 19 10 10 CD cord-015306-us58wwmp 136 20 % % NN cord-015306-us58wwmp 136 21 had have VBD cord-015306-us58wwmp 136 22 severe severe JJ cord-015306-us58wwmp 136 23 VUR VUR NNP cord-015306-us58wwmp 136 24 ) ) -RRB- cord-015306-us58wwmp 136 25 . . . cord-015306-us58wwmp 137 1 Hydronephrosis Hydronephrosis NNP cord-015306-us58wwmp 137 2 was be VBD cord-015306-us58wwmp 137 3 seen see VBN cord-015306-us58wwmp 137 4 in in IN cord-015306-us58wwmp 137 5 56 56 CD cord-015306-us58wwmp 137 6 % % NN cord-015306-us58wwmp 137 7 of of IN cord-015306-us58wwmp 137 8 patients patient NNS cord-015306-us58wwmp 137 9 with with IN cord-015306-us58wwmp 137 10 VUR VUR NNP cord-015306-us58wwmp 137 11 . . . cord-015306-us58wwmp 138 1 Of of IN cord-015306-us58wwmp 138 2 these these DT cord-015306-us58wwmp 138 3 , , , cord-015306-us58wwmp 138 4 45 45 CD cord-015306-us58wwmp 138 5 % % NN cord-015306-us58wwmp 138 6 were be VBD cord-015306-us58wwmp 138 7 unilateral unilateral JJ cord-015306-us58wwmp 138 8 and and CC cord-015306-us58wwmp 138 9 55 55 CD cord-015306-us58wwmp 138 10 % % NN cord-015306-us58wwmp 138 11 were be VBD cord-015306-us58wwmp 138 12 bilateral bilateral JJ cord-015306-us58wwmp 138 13 . . . cord-015306-us58wwmp 139 1 There there EX cord-015306-us58wwmp 139 2 was be VBD cord-015306-us58wwmp 139 3 no no DT cord-015306-us58wwmp 139 4 significant significant JJ cord-015306-us58wwmp 139 5 difference difference NN cord-015306-us58wwmp 139 6 in in IN cord-015306-us58wwmp 139 7 the the DT cord-015306-us58wwmp 139 8 presence presence NN cord-015306-us58wwmp 139 9 of of IN cord-015306-us58wwmp 139 10 hydronephrosis hydronephrosis NN cord-015306-us58wwmp 139 11 and and CC cord-015306-us58wwmp 139 12 grade grade NN cord-015306-us58wwmp 139 13 of of IN cord-015306-us58wwmp 139 14 VUR VUR NNP cord-015306-us58wwmp 139 15 . . . cord-015306-us58wwmp 140 1 There there EX cord-015306-us58wwmp 140 2 was be VBD cord-015306-us58wwmp 140 3 no no DT cord-015306-us58wwmp 140 4 significant significant JJ cord-015306-us58wwmp 140 5 difference difference NN cord-015306-us58wwmp 140 6 in in IN cord-015306-us58wwmp 140 7 presence presence NN cord-015306-us58wwmp 140 8 of of IN cord-015306-us58wwmp 140 9 scars scar NNS cord-015306-us58wwmp 140 10 between between IN cord-015306-us58wwmp 140 11 mild mild JJ cord-015306-us58wwmp 140 12 and and CC cord-015306-us58wwmp 140 13 mod mod JJ cord-015306-us58wwmp 140 14 - - HYPH cord-015306-us58wwmp 140 15 severe severe JJ cord-015306-us58wwmp 140 16 VUR VUR NNP cord-015306-us58wwmp 140 17 . . . cord-015306-us58wwmp 141 1 At at IN cord-015306-us58wwmp 141 2 the the DT cord-015306-us58wwmp 141 3 end end NN cord-015306-us58wwmp 141 4 of of IN cord-015306-us58wwmp 141 5 3 3 CD cord-015306-us58wwmp 141 6 years year NNS cord-015306-us58wwmp 141 7 of of IN cord-015306-us58wwmp 141 8 follow follow VB cord-015306-us58wwmp 141 9 up up RP cord-015306-us58wwmp 141 10 , , , cord-015306-us58wwmp 141 11 complete complete JJ cord-015306-us58wwmp 141 12 resolution resolution NN cord-015306-us58wwmp 141 13 of of IN cord-015306-us58wwmp 141 14 reflux reflux NN cord-015306-us58wwmp 141 15 was be VBD cord-015306-us58wwmp 141 16 seen see VBN cord-015306-us58wwmp 141 17 in in IN cord-015306-us58wwmp 141 18 53 53 CD cord-015306-us58wwmp 141 19 % % NN cord-015306-us58wwmp 141 20 , , , cord-015306-us58wwmp 141 21 43 43 CD cord-015306-us58wwmp 141 22 % % NN cord-015306-us58wwmp 141 23 and and CC cord-015306-us58wwmp 141 24 55 55 CD cord-015306-us58wwmp 141 25 % % NN cord-015306-us58wwmp 141 26 of of IN cord-015306-us58wwmp 141 27 children child NNS cord-015306-us58wwmp 141 28 with with IN cord-015306-us58wwmp 141 29 mild mild JJ cord-015306-us58wwmp 141 30 , , , cord-015306-us58wwmp 141 31 moderate moderate JJ cord-015306-us58wwmp 141 32 and and CC cord-015306-us58wwmp 141 33 severe severe JJ cord-015306-us58wwmp 141 34 VUR VUR NNP cord-015306-us58wwmp 141 35 respectively respectively RB cord-015306-us58wwmp 141 36 . . . cord-015306-us58wwmp 142 1 Conclusion conclusion NN cord-015306-us58wwmp 142 2 : : : cord-015306-us58wwmp 143 1 Severity severity NN cord-015306-us58wwmp 143 2 of of IN cord-015306-us58wwmp 143 3 VUR VUR NNP cord-015306-us58wwmp 143 4 did do VBD cord-015306-us58wwmp 143 5 not not RB cord-015306-us58wwmp 143 6 necessarily necessarily RB cord-015306-us58wwmp 143 7 correlate correlate VB cord-015306-us58wwmp 143 8 with with IN cord-015306-us58wwmp 143 9 hydronephrosis hydronephrosis NN cord-015306-us58wwmp 143 10 and and CC cord-015306-us58wwmp 143 11 parenchymal parenchymal NN cord-015306-us58wwmp 143 12 scarring scarring NN cord-015306-us58wwmp 143 13 . . . cord-015306-us58wwmp 144 1 Over over IN cord-015306-us58wwmp 144 2 a a DT cord-015306-us58wwmp 144 3 3 3 CD cord-015306-us58wwmp 144 4 year year NN cord-015306-us58wwmp 144 5 follow follow VB cord-015306-us58wwmp 144 6 up up RP cord-015306-us58wwmp 144 7 , , , cord-015306-us58wwmp 144 8 complete complete JJ cord-015306-us58wwmp 144 9 resolution resolution NN cord-015306-us58wwmp 144 10 of of IN cord-015306-us58wwmp 144 11 reflux reflux NN cord-015306-us58wwmp 144 12 was be VBD cord-015306-us58wwmp 144 13 seen see VBN cord-015306-us58wwmp 144 14 in in IN cord-015306-us58wwmp 144 15 nearly nearly RB cord-015306-us58wwmp 144 16 50 50 CD cord-015306-us58wwmp 144 17 % % NN cord-015306-us58wwmp 144 18 of of IN cord-015306-us58wwmp 144 19 children child NNS cord-015306-us58wwmp 144 20 irrespective irrespective RB cord-015306-us58wwmp 144 21 of of IN cord-015306-us58wwmp 144 22 the the DT cord-015306-us58wwmp 144 23 grade grade NN cord-015306-us58wwmp 144 24 of of IN cord-015306-us58wwmp 144 25 reflux reflux NN cord-015306-us58wwmp 144 26 . . . cord-015306-us58wwmp 145 1 Abstract abstract JJ cord-015306-us58wwmp 145 2 # # NN cord-015306-us58wwmp 145 3 P P NNP cord-015306-us58wwmp 145 4 - - HYPH cord-015306-us58wwmp 145 5 SAT044 SAT044 NNP cord-015306-us58wwmp 145 6 Growth Growth NNP cord-015306-us58wwmp 145 7 in in IN cord-015306-us58wwmp 145 8 children child NNS cord-015306-us58wwmp 145 9 with with IN cord-015306-us58wwmp 145 10 dilating dilate VBG cord-015306-us58wwmp 145 11 VUR VUR NNP cord-015306-us58wwmp 145 12 -a -a , cord-015306-us58wwmp 145 13 follow follow VBP cord-015306-us58wwmp 145 14 up up IN cord-015306-us58wwmp 145 15 of of IN cord-015306-us58wwmp 145 16 the the DT cord-015306-us58wwmp 145 17 Swedish swedish JJ cord-015306-us58wwmp 145 18 Reflux reflux NN cord-015306-us58wwmp 145 19 Trial Trial NNP cord-015306-us58wwmp 145 20 Per per IN cord-015306-us58wwmp 145 21 Brandstrom Brandstrom NNP cord-015306-us58wwmp 145 22 , , , cord-015306-us58wwmp 145 23 Sverker Sverker NNP cord-015306-us58wwmp 145 24 Hansson Hansson NNP cord-015306-us58wwmp 145 25 Pediatricuronephrologic Pediatricuronephrologic NNP cord-015306-us58wwmp 145 26 center center NN cord-015306-us58wwmp 145 27 , , , cord-015306-us58wwmp 145 28 University University NNP cord-015306-us58wwmp 145 29 of of IN cord-015306-us58wwmp 145 30 Gothenburg Gothenburg NNP cord-015306-us58wwmp 145 31 , , , cord-015306-us58wwmp 145 32 Gothenburg Gothenburg NNP cord-015306-us58wwmp 145 33 , , , cord-015306-us58wwmp 146 1 Sweden Sweden NNP cord-015306-us58wwmp 146 2 Objective Objective NNP cord-015306-us58wwmp 146 3 : : : cord-015306-us58wwmp 147 1 The the DT cord-015306-us58wwmp 147 2 Swedish swedish JJ cord-015306-us58wwmp 147 3 Reflux reflux NN cord-015306-us58wwmp 147 4 Trial Trial NNP cord-015306-us58wwmp 147 5 included include VBD cord-015306-us58wwmp 147 6 203 203 CD cord-015306-us58wwmp 147 7 children child NNS cord-015306-us58wwmp 147 8 , , , cord-015306-us58wwmp 147 9 1 1 CD cord-015306-us58wwmp 147 10 - - SYM cord-015306-us58wwmp 147 11 2 2 CD cord-015306-us58wwmp 147 12 years year NNS cord-015306-us58wwmp 147 13 of of IN cord-015306-us58wwmp 147 14 age age NN cord-015306-us58wwmp 147 15 , , , cord-015306-us58wwmp 147 16 with with IN cord-015306-us58wwmp 147 17 VUR VUR NNP cord-015306-us58wwmp 147 18 grade grade NN cord-015306-us58wwmp 147 19 3 3 CD cord-015306-us58wwmp 147 20 - - SYM cord-015306-us58wwmp 147 21 4 4 CD cord-015306-us58wwmp 147 22 , , , cord-015306-us58wwmp 147 23 diagnosed diagnose VBN cord-015306-us58wwmp 147 24 after after IN cord-015306-us58wwmp 147 25 UTI UTI NNP cord-015306-us58wwmp 147 26 in in IN cord-015306-us58wwmp 147 27 194 194 CD cord-015306-us58wwmp 147 28 and and CC cord-015306-us58wwmp 147 29 prenatal prenatal JJ cord-015306-us58wwmp 147 30 urinary urinary JJ cord-015306-us58wwmp 147 31 tract tract NN cord-015306-us58wwmp 147 32 dilatation dilatation NN cord-015306-us58wwmp 147 33 in in IN cord-015306-us58wwmp 147 34 9 9 CD cord-015306-us58wwmp 147 35 . . . cord-015306-us58wwmp 148 1 DMSA DMSA NNP cord-015306-us58wwmp 148 2 was be VBD cord-015306-us58wwmp 148 3 abnormal abnormal JJ cord-015306-us58wwmp 148 4 at at IN cord-015306-us58wwmp 148 5 start start NN cord-015306-us58wwmp 148 6 in in IN cord-015306-us58wwmp 148 7 124 124 CD cord-015306-us58wwmp 148 8 children child NNS cord-015306-us58wwmp 148 9 ( ( -LRB- cord-015306-us58wwmp 148 10 61 61 CD cord-015306-us58wwmp 148 11 % % NN cord-015306-us58wwmp 148 12 ) ) -RRB- cord-015306-us58wwmp 148 13 . . . cord-015306-us58wwmp 149 1 The the DT cord-015306-us58wwmp 149 2 children child NNS cord-015306-us58wwmp 149 3 were be VBD cord-015306-us58wwmp 149 4 randomized randomize VBN cord-015306-us58wwmp 149 5 to to IN cord-015306-us58wwmp 149 6 antibiotic antibiotic JJ cord-015306-us58wwmp 149 7 prophylaxis prophylaxis NN cord-015306-us58wwmp 149 8 , , , cord-015306-us58wwmp 149 9 endoscopic endoscopic JJ cord-015306-us58wwmp 149 10 injection injection NN cord-015306-us58wwmp 149 11 with with IN cord-015306-us58wwmp 149 12 Deflux Deflux NNP cord-015306-us58wwmp 149 13 ™ ™ NN cord-015306-us58wwmp 149 14 or or CC cord-015306-us58wwmp 149 15 surveillance surveillance NN cord-015306-us58wwmp 149 16 . . . cord-015306-us58wwmp 150 1 There there EX cord-015306-us58wwmp 150 2 have have VBP cord-015306-us58wwmp 150 3 been be VBN cord-015306-us58wwmp 150 4 reports report NNS cord-015306-us58wwmp 150 5 on on IN cord-015306-us58wwmp 150 6 growth growth NN cord-015306-us58wwmp 150 7 retardation retardation NN cord-015306-us58wwmp 150 8 in in IN cord-015306-us58wwmp 150 9 children child NNS cord-015306-us58wwmp 150 10 with with IN cord-015306-us58wwmp 150 11 VUR VUR NNP cord-015306-us58wwmp 150 12 and and CC cord-015306-us58wwmp 150 13 catch catch VB cord-015306-us58wwmp 150 14 up up RP cord-015306-us58wwmp 150 15 after after IN cord-015306-us58wwmp 150 16 VUR VUR NNP cord-015306-us58wwmp 150 17 resolution resolution NN cord-015306-us58wwmp 150 18 . . . cord-015306-us58wwmp 151 1 The the DT cord-015306-us58wwmp 151 2 mechanism mechanism NN cord-015306-us58wwmp 151 3 behind behind IN cord-015306-us58wwmp 151 4 these these DT cord-015306-us58wwmp 151 5 findings finding NNS cord-015306-us58wwmp 151 6 is be VBZ cord-015306-us58wwmp 151 7 unclear unclear JJ cord-015306-us58wwmp 151 8 . . . cord-015306-us58wwmp 152 1 The the DT cord-015306-us58wwmp 152 2 children child NNS cord-015306-us58wwmp 152 3 of of IN cord-015306-us58wwmp 152 4 the the DT cord-015306-us58wwmp 152 5 Swedish swedish JJ cord-015306-us58wwmp 152 6 Reflux Reflux NNP cord-015306-us58wwmp 152 7 Trial Trial NNP cord-015306-us58wwmp 152 8 constitute constitute VBP cord-015306-us58wwmp 152 9 a a DT cord-015306-us58wwmp 152 10 high high JJ cord-015306-us58wwmp 152 11 risk risk NN cord-015306-us58wwmp 152 12 group group NN cord-015306-us58wwmp 152 13 with with IN cord-015306-us58wwmp 152 14 dilating dilate VBG cord-015306-us58wwmp 152 15 VUR VUR NNP cord-015306-us58wwmp 152 16 , , , cord-015306-us58wwmp 152 17 recurrent recurrent JJ cord-015306-us58wwmp 152 18 febrile febrile JJ cord-015306-us58wwmp 152 19 UTI UTI NNP cord-015306-us58wwmp 152 20 and and CC cord-015306-us58wwmp 152 21 high high JJ cord-015306-us58wwmp 152 22 prevalence prevalence NN cord-015306-us58wwmp 152 23 of of IN cord-015306-us58wwmp 152 24 renal renal JJ cord-015306-us58wwmp 152 25 parenchymal parenchymal NN cord-015306-us58wwmp 152 26 defects defect NNS cord-015306-us58wwmp 152 27 . . . cord-015306-us58wwmp 153 1 We -PRON- PRP cord-015306-us58wwmp 153 2 have have VBP cord-015306-us58wwmp 153 3 searched search VBN cord-015306-us58wwmp 153 4 the the DT cord-015306-us58wwmp 153 5 growth growth NN cord-015306-us58wwmp 153 6 pattern pattern NN cord-015306-us58wwmp 153 7 of of IN cord-015306-us58wwmp 153 8 these these DT cord-015306-us58wwmp 153 9 children child NNS cord-015306-us58wwmp 153 10 for for IN cord-015306-us58wwmp 153 11 differences difference NNS cord-015306-us58wwmp 153 12 related relate VBN cord-015306-us58wwmp 153 13 to to IN cord-015306-us58wwmp 153 14 gender gender NN cord-015306-us58wwmp 153 15 , , , cord-015306-us58wwmp 153 16 treatment treatment NN cord-015306-us58wwmp 153 17 group group NN cord-015306-us58wwmp 153 18 , , , cord-015306-us58wwmp 153 19 UTI UTI NNP cord-015306-us58wwmp 153 20 recurrence recurrence NN cord-015306-us58wwmp 153 21 , , , cord-015306-us58wwmp 153 22 VUR VUR NNP cord-015306-us58wwmp 153 23 grade grade NN cord-015306-us58wwmp 153 24 at at IN cord-015306-us58wwmp 153 25 follow follow NN cord-015306-us58wwmp 153 26 up up RP cord-015306-us58wwmp 153 27 or or CC cord-015306-us58wwmp 153 28 renal renal JJ cord-015306-us58wwmp 153 29 defects defect NNS cord-015306-us58wwmp 153 30 on on IN cord-015306-us58wwmp 153 31 DMSA DMSA NNS cord-015306-us58wwmp 153 32 . . . cord-015306-us58wwmp 154 1 Methods method NNS cord-015306-us58wwmp 154 2 : : : cord-015306-us58wwmp 154 3 Height height NN cord-015306-us58wwmp 154 4 and and CC cord-015306-us58wwmp 154 5 weight weight NN cord-015306-us58wwmp 154 6 Z z NN cord-015306-us58wwmp 154 7 - - HYPH cord-015306-us58wwmp 154 8 scores score NNS cord-015306-us58wwmp 154 9 , , , cord-015306-us58wwmp 154 10 compared compare VBN cord-015306-us58wwmp 154 11 to to IN cord-015306-us58wwmp 154 12 standardized standardized JJ cord-015306-us58wwmp 154 13 Swedish swedish JJ cord-015306-us58wwmp 154 14 growth growth NN cord-015306-us58wwmp 154 15 charts chart NNS cord-015306-us58wwmp 154 16 , , , cord-015306-us58wwmp 154 17 were be VBD cord-015306-us58wwmp 154 18 registered register VBN cord-015306-us58wwmp 154 19 during during IN cord-015306-us58wwmp 154 20 the the DT cord-015306-us58wwmp 154 21 2 2 CD cord-015306-us58wwmp 154 22 year year NN cord-015306-us58wwmp 154 23 follow follow VB cord-015306-us58wwmp 154 24 up up RB cord-015306-us58wwmp 154 25 in in IN cord-015306-us58wwmp 154 26 199 199 CD cord-015306-us58wwmp 154 27 of of IN cord-015306-us58wwmp 154 28 the the DT cord-015306-us58wwmp 154 29 children child NNS cord-015306-us58wwmp 154 30 in in IN cord-015306-us58wwmp 154 31 the the DT cord-015306-us58wwmp 154 32 trial trial NN cord-015306-us58wwmp 154 33 and and CC cord-015306-us58wwmp 154 34 at at IN cord-015306-us58wwmp 154 35 outpatient outpatient NN cord-015306-us58wwmp 154 36 visits visit NNS cord-015306-us58wwmp 154 37 thereafter thereafter RB cord-015306-us58wwmp 154 38 in in IN cord-015306-us58wwmp 154 39 129 129 CD cord-015306-us58wwmp 154 40 patients patient NNS cord-015306-us58wwmp 154 41 to to IN cord-015306-us58wwmp 154 42 the the DT cord-015306-us58wwmp 154 43 age age NN cord-015306-us58wwmp 154 44 of of IN cord-015306-us58wwmp 154 45 5.3 5.3 CD cord-015306-us58wwmp 154 46 years year NNS cord-015306-us58wwmp 154 47 ( ( -LRB- cord-015306-us58wwmp 154 48 median median NN cord-015306-us58wwmp 154 49 , , , cord-015306-us58wwmp 154 50 range range VBP cord-015306-us58wwmp 154 51 2.0 2.0 CD cord-015306-us58wwmp 154 52 - - HYPH cord-015306-us58wwmp 154 53 11.8 11.8 CD cord-015306-us58wwmp 154 54 ) ) -RRB- cord-015306-us58wwmp 154 55 . . . cord-015306-us58wwmp 155 1 Change change VB cord-015306-us58wwmp 155 2 in in IN cord-015306-us58wwmp 155 3 height height NN cord-015306-us58wwmp 155 4 Z z NN cord-015306-us58wwmp 155 5 - - HYPH cord-015306-us58wwmp 155 6 score score NN cord-015306-us58wwmp 155 7 between between IN cord-015306-us58wwmp 155 8 first first JJ cord-015306-us58wwmp 155 9 and and CC cord-015306-us58wwmp 155 10 last last JJ cord-015306-us58wwmp 155 11 visit visit NN cord-015306-us58wwmp 155 12 was be VBD cord-015306-us58wwmp 155 13 used use VBN cord-015306-us58wwmp 155 14 to to TO cord-015306-us58wwmp 155 15 measure measure VB cord-015306-us58wwmp 155 16 growth growth NN cord-015306-us58wwmp 155 17 over over IN cord-015306-us58wwmp 155 18 time time NN cord-015306-us58wwmp 155 19 . . . cord-015306-us58wwmp 156 1 Results result NNS cord-015306-us58wwmp 156 2 : : : cord-015306-us58wwmp 157 1 The the DT cord-015306-us58wwmp 157 2 first first JJ cord-015306-us58wwmp 157 3 and and CC cord-015306-us58wwmp 157 4 last last JJ cord-015306-us58wwmp 157 5 recorded record VBN cord-015306-us58wwmp 157 6 height height NN cord-015306-us58wwmp 157 7 and and CC cord-015306-us58wwmp 157 8 weight weight NN cord-015306-us58wwmp 157 9 Z z NN cord-015306-us58wwmp 157 10 - - HYPH cord-015306-us58wwmp 157 11 scores score NNS cord-015306-us58wwmp 157 12 were be VBD cord-015306-us58wwmp 157 13 all all RB cord-015306-us58wwmp 157 14 within within IN cord-015306-us58wwmp 157 15 normal normal JJ cord-015306-us58wwmp 157 16 range range NN cord-015306-us58wwmp 157 17 . . . cord-015306-us58wwmp 158 1 There there EX cord-015306-us58wwmp 158 2 was be VBD cord-015306-us58wwmp 158 3 a a DT cord-015306-us58wwmp 158 4 larger large JJR cord-015306-us58wwmp 158 5 gain gain NN cord-015306-us58wwmp 158 6 of of IN cord-015306-us58wwmp 158 7 height height NN cord-015306-us58wwmp 158 8 in in IN cord-015306-us58wwmp 158 9 children child NNS cord-015306-us58wwmp 158 10 with with IN cord-015306-us58wwmp 158 11 renal renal JJ cord-015306-us58wwmp 158 12 defects defect NNS cord-015306-us58wwmp 158 13 compared compare VBN cord-015306-us58wwmp 158 14 to to IN cord-015306-us58wwmp 158 15 those those DT cord-015306-us58wwmp 158 16 without without IN cord-015306-us58wwmp 158 17 ( ( -LRB- cord-015306-us58wwmp 158 18 Z z NN cord-015306-us58wwmp 158 19 - - HYPH cord-015306-us58wwmp 158 20 score score NN cord-015306-us58wwmp 158 21 difference difference NN cord-015306-us58wwmp 158 22 0.42 0.42 CD cord-015306-us58wwmp 158 23 vs. vs. NN cord-015306-us58wwmp 158 24 0.13 0.13 CD cord-015306-us58wwmp 158 25 , , , cord-015306-us58wwmp 158 26 p=0.009 p=0.009 NN cord-015306-us58wwmp 158 27 ) ) -RRB- cord-015306-us58wwmp 158 28 . . . cord-015306-us58wwmp 159 1 There there EX cord-015306-us58wwmp 159 2 were be VBD cord-015306-us58wwmp 159 3 no no DT cord-015306-us58wwmp 159 4 differences difference NNS cord-015306-us58wwmp 159 5 in in IN cord-015306-us58wwmp 159 6 growth growth NN cord-015306-us58wwmp 159 7 related relate VBN cord-015306-us58wwmp 159 8 to to IN cord-015306-us58wwmp 159 9 gender gender NN cord-015306-us58wwmp 159 10 , , , cord-015306-us58wwmp 159 11 treatment treatment NN cord-015306-us58wwmp 159 12 group group NN cord-015306-us58wwmp 159 13 , , , cord-015306-us58wwmp 159 14 VUR VUR NNP cord-015306-us58wwmp 159 15 - - HYPH cord-015306-us58wwmp 159 16 grade grade NN cord-015306-us58wwmp 159 17 at at IN cord-015306-us58wwmp 159 18 follow follow NN cord-015306-us58wwmp 159 19 up up RP cord-015306-us58wwmp 159 20 or or CC cord-015306-us58wwmp 159 21 recurrent recurrent JJ cord-015306-us58wwmp 159 22 UTI UTI NNP cord-015306-us58wwmp 159 23 . . . cord-015306-us58wwmp 160 1 Conclusion conclusion NN cord-015306-us58wwmp 160 2 : : : cord-015306-us58wwmp 161 1 The the DT cord-015306-us58wwmp 161 2 children child NNS cord-015306-us58wwmp 161 3 of of IN cord-015306-us58wwmp 161 4 the the DT cord-015306-us58wwmp 161 5 Swedish swedish JJ cord-015306-us58wwmp 161 6 Reflux Reflux NNP cord-015306-us58wwmp 161 7 Trial Trial NNP cord-015306-us58wwmp 161 8 constitute constitute VBP cord-015306-us58wwmp 161 9 a a DT cord-015306-us58wwmp 161 10 high high JJ cord-015306-us58wwmp 161 11 risk risk NN cord-015306-us58wwmp 161 12 group group NN cord-015306-us58wwmp 161 13 with with IN cord-015306-us58wwmp 161 14 dilating dilate VBG cord-015306-us58wwmp 161 15 VUR VUR NNP cord-015306-us58wwmp 161 16 , , , cord-015306-us58wwmp 161 17 recurrent recurrent JJ cord-015306-us58wwmp 161 18 febrile febrile JJ cord-015306-us58wwmp 161 19 UTI UTI NNP cord-015306-us58wwmp 161 20 and and CC cord-015306-us58wwmp 161 21 high high JJ cord-015306-us58wwmp 161 22 prevalence prevalence NN cord-015306-us58wwmp 161 23 of of IN cord-015306-us58wwmp 161 24 renal renal JJ cord-015306-us58wwmp 161 25 parenchymal parenchymal NN cord-015306-us58wwmp 161 26 defects defect NNS cord-015306-us58wwmp 161 27 . . . cord-015306-us58wwmp 162 1 They -PRON- PRP cord-015306-us58wwmp 162 2 have have VBP cord-015306-us58wwmp 162 3 normal normal JJ cord-015306-us58wwmp 162 4 weight weight NN cord-015306-us58wwmp 162 5 , , , cord-015306-us58wwmp 162 6 height height NN cord-015306-us58wwmp 162 7 and and CC cord-015306-us58wwmp 162 8 height height NN cord-015306-us58wwmp 162 9 gain gain NN cord-015306-us58wwmp 162 10 at at IN cord-015306-us58wwmp 162 11 follow follow NN cord-015306-us58wwmp 162 12 up up RP cord-015306-us58wwmp 162 13 for for IN cord-015306-us58wwmp 162 14 up up IN cord-015306-us58wwmp 162 15 to to TO cord-015306-us58wwmp 162 16 10 10 CD cord-015306-us58wwmp 162 17 years year NNS cord-015306-us58wwmp 162 18 . . . cord-015306-us58wwmp 163 1 There there EX cord-015306-us58wwmp 163 2 was be VBD cord-015306-us58wwmp 163 3 no no DT cord-015306-us58wwmp 163 4 sign sign NN cord-015306-us58wwmp 163 5 of of IN cord-015306-us58wwmp 163 6 growth growth NN cord-015306-us58wwmp 163 7 inhibition inhibition NN cord-015306-us58wwmp 163 8 in in IN cord-015306-us58wwmp 163 9 these these DT cord-015306-us58wwmp 163 10 children child NNS cord-015306-us58wwmp 163 11 related relate VBN cord-015306-us58wwmp 163 12 to to IN cord-015306-us58wwmp 163 13 dilating dilate VBG cord-015306-us58wwmp 163 14 VUR VUR NNP cord-015306-us58wwmp 163 15 . . . cord-015306-us58wwmp 164 1 The the DT cord-015306-us58wwmp 164 2 larger large JJR cord-015306-us58wwmp 164 3 height height NN cord-015306-us58wwmp 164 4 gain gain NN cord-015306-us58wwmp 164 5 seen see VBN cord-015306-us58wwmp 164 6 in in IN cord-015306-us58wwmp 164 7 those those DT cord-015306-us58wwmp 164 8 with with IN cord-015306-us58wwmp 164 9 renal renal JJ cord-015306-us58wwmp 164 10 defects defect NNS cord-015306-us58wwmp 164 11 seem seem VBP cord-015306-us58wwmp 164 12 to to TO cord-015306-us58wwmp 164 13 be be VB cord-015306-us58wwmp 164 14 due due JJ cord-015306-us58wwmp 164 15 to to IN cord-015306-us58wwmp 164 16 their -PRON- PRP$ cord-015306-us58wwmp 164 17 slightly slightly RB cord-015306-us58wwmp 164 18 shorter short JJR cord-015306-us58wwmp 164 19 stature stature NN cord-015306-us58wwmp 164 20 at at IN cord-015306-us58wwmp 164 21 study study NN cord-015306-us58wwmp 164 22 start start NN cord-015306-us58wwmp 164 23 , , , cord-015306-us58wwmp 164 24 although although IN cord-015306-us58wwmp 164 25 within within IN cord-015306-us58wwmp 164 26 normal normal JJ cord-015306-us58wwmp 164 27 range range NN cord-015306-us58wwmp 164 28 , , , cord-015306-us58wwmp 164 29 which which WDT cord-015306-us58wwmp 164 30 could could MD cord-015306-us58wwmp 164 31 be be VB cord-015306-us58wwmp 164 32 related relate VBN cord-015306-us58wwmp 164 33 to to IN cord-015306-us58wwmp 164 34 more more RBR cord-015306-us58wwmp 164 35 severe severe JJ cord-015306-us58wwmp 164 36 urinary urinary JJ cord-015306-us58wwmp 164 37 tract tract NN cord-015306-us58wwmp 164 38 and and CC cord-015306-us58wwmp 164 39 renal renal JJ cord-015306-us58wwmp 164 40 problems problem NNS cord-015306-us58wwmp 164 41 during during IN cord-015306-us58wwmp 164 42 their -PRON- PRP$ cord-015306-us58wwmp 164 43 first first JJ cord-015306-us58wwmp 164 44 1 1 CD cord-015306-us58wwmp 164 45 - - SYM cord-015306-us58wwmp 164 46 2 2 CD cord-015306-us58wwmp 164 47 years year NNS cord-015306-us58wwmp 164 48 of of IN cord-015306-us58wwmp 164 49 life life NN cord-015306-us58wwmp 164 50 . . . cord-015306-us58wwmp 165 1 Engin Engin NNP cord-015306-us58wwmp 165 2 Kose Kose NNP cord-015306-us58wwmp 165 3 , , , cord-015306-us58wwmp 165 4 Caner Caner NNP cord-015306-us58wwmp 165 5 Alparslan Alparslan NNP cord-015306-us58wwmp 165 6 , , , cord-015306-us58wwmp 165 7 Serdar Serdar NNP cord-015306-us58wwmp 165 8 Saritas Saritas NNP cord-015306-us58wwmp 165 9 , , , cord-015306-us58wwmp 165 10 Cengizhan Cengizhan NNP cord-015306-us58wwmp 165 11 Elmas Elmas NNP cord-015306-us58wwmp 165 12 , , , cord-015306-us58wwmp 165 13 Fatma Fatma NNP cord-015306-us58wwmp 165 14 Mutlubas Mutlubas NNP cord-015306-us58wwmp 165 15 Ozsan Ozsan NNP cord-015306-us58wwmp 165 16 , , , cord-015306-us58wwmp 165 17 Onder Onder NNP cord-015306-us58wwmp 165 18 Yavascan Yavascan NNP cord-015306-us58wwmp 165 19 , , , cord-015306-us58wwmp 165 20 Nejat Nejat NNP cord-015306-us58wwmp 165 21 Aksu Aksu NNP cord-015306-us58wwmp 165 22 Tepecik Tepecik NNP cord-015306-us58wwmp 165 23 Training Training NNP cord-015306-us58wwmp 165 24 and and CC cord-015306-us58wwmp 165 25 Research Research NNP cord-015306-us58wwmp 165 26 Hospital Hospital NNP cord-015306-us58wwmp 165 27 , , , cord-015306-us58wwmp 165 28 Pediatric Pediatric NNP cord-015306-us58wwmp 165 29 Nephrology Nephrology NNP cord-015306-us58wwmp 165 30 , , , cord-015306-us58wwmp 165 31 Izmir Izmir NNP cord-015306-us58wwmp 165 32 , , , cord-015306-us58wwmp 166 1 Turkey Turkey NNP cord-015306-us58wwmp 166 2 Objective Objective NNP cord-015306-us58wwmp 166 3 : : : cord-015306-us58wwmp 167 1 The the DT cord-015306-us58wwmp 167 2 management management NN cord-015306-us58wwmp 167 3 of of IN cord-015306-us58wwmp 167 4 vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 167 5 reflux reflux NN cord-015306-us58wwmp 167 6 ( ( -LRB- cord-015306-us58wwmp 167 7 VUR VUR NNP cord-015306-us58wwmp 167 8 ) ) -RRB- cord-015306-us58wwmp 167 9 is be VBZ cord-015306-us58wwmp 167 10 varied varied JJ cord-015306-us58wwmp 167 11 and and CC cord-015306-us58wwmp 167 12 remains remain VBZ cord-015306-us58wwmp 167 13 controversial controversial JJ cord-015306-us58wwmp 167 14 . . . cord-015306-us58wwmp 168 1 Conservative conservative JJ cord-015306-us58wwmp 168 2 therapy therapy NN cord-015306-us58wwmp 168 3 is be VBZ cord-015306-us58wwmp 168 4 based base VBN cord-015306-us58wwmp 168 5 on on IN cord-015306-us58wwmp 168 6 the the DT cord-015306-us58wwmp 168 7 understanding understanding NN cord-015306-us58wwmp 168 8 that that WDT cord-015306-us58wwmp 168 9 VUR VUR NNP cord-015306-us58wwmp 168 10 can can MD cord-015306-us58wwmp 168 11 resolve resolve VB cord-015306-us58wwmp 168 12 spontaneously spontaneously RB cord-015306-us58wwmp 168 13 , , , cord-015306-us58wwmp 168 14 mostly mostly RB cord-015306-us58wwmp 168 15 in in IN cord-015306-us58wwmp 168 16 young young JJ cord-015306-us58wwmp 168 17 patients patient NNS cord-015306-us58wwmp 168 18 with with IN cord-015306-us58wwmp 168 19 low low JJ cord-015306-us58wwmp 168 20 - - HYPH cord-015306-us58wwmp 168 21 grade grade NN cord-015306-us58wwmp 168 22 reflux reflux NN cord-015306-us58wwmp 168 23 . . . cord-015306-us58wwmp 169 1 In in IN cord-015306-us58wwmp 169 2 this this DT cord-015306-us58wwmp 169 3 study study NN cord-015306-us58wwmp 169 4 , , , cord-015306-us58wwmp 169 5 we -PRON- PRP cord-015306-us58wwmp 169 6 wanted want VBD cord-015306-us58wwmp 169 7 to to TO cord-015306-us58wwmp 169 8 evaluate evaluate VB cord-015306-us58wwmp 169 9 the the DT cord-015306-us58wwmp 169 10 spontaneousresolution spontaneousresolution NN cord-015306-us58wwmp 169 11 rate rate NN cord-015306-us58wwmp 169 12 of of IN cord-015306-us58wwmp 169 13 low low JJ cord-015306-us58wwmp 169 14 - - HYPH cord-015306-us58wwmp 169 15 grade grade NN cord-015306-us58wwmp 169 16 VUR VUR NNP cord-015306-us58wwmp 169 17 ( ( -LRB- cord-015306-us58wwmp 169 18 grades grade NNS cord-015306-us58wwmp 169 19 I -PRON- PRP cord-015306-us58wwmp 169 20 and and CC cord-015306-us58wwmp 169 21 II II NNP cord-015306-us58wwmp 169 22 ) ) -RRB- cord-015306-us58wwmp 169 23 in in IN cord-015306-us58wwmp 169 24 children child NNS cord-015306-us58wwmp 169 25 . . . cord-015306-us58wwmp 170 1 Methods method NNS cord-015306-us58wwmp 170 2 : : : cord-015306-us58wwmp 170 3 Children child NNS cord-015306-us58wwmp 170 4 with with IN cord-015306-us58wwmp 170 5 low low JJ cord-015306-us58wwmp 170 6 - - HYPH cord-015306-us58wwmp 170 7 grade grade NN cord-015306-us58wwmp 170 8 ( ( -LRB- cord-015306-us58wwmp 170 9 I I NNP cord-015306-us58wwmp 170 10 - - HYPH cord-015306-us58wwmp 170 11 II II NNP cord-015306-us58wwmp 170 12 ) ) -RRB- cord-015306-us58wwmp 170 13 VUR VUR NNP cord-015306-us58wwmp 170 14 treated treat VBD cord-015306-us58wwmp 170 15 in in IN cord-015306-us58wwmp 170 16 our -PRON- PRP$ cord-015306-us58wwmp 170 17 hospital hospital NN cord-015306-us58wwmp 170 18 from from IN cord-015306-us58wwmp 170 19 May May NNP cord-015306-us58wwmp 170 20 2010 2010 CD cord-015306-us58wwmp 170 21 to to IN cord-015306-us58wwmp 170 22 May May NNP cord-015306-us58wwmp 170 23 2012 2012 CD cord-015306-us58wwmp 170 24 were be VBD cord-015306-us58wwmp 170 25 prospectively prospectively RB cord-015306-us58wwmp 170 26 studied study VBN cord-015306-us58wwmp 170 27 . . . cord-015306-us58wwmp 171 1 Patients patient NNS cord-015306-us58wwmp 171 2 with with IN cord-015306-us58wwmp 171 3 low low JJ cord-015306-us58wwmp 171 4 - - HYPH cord-015306-us58wwmp 171 5 grade grade NN cord-015306-us58wwmp 171 6 ( ( -LRB- cord-015306-us58wwmp 171 7 I I NNP cord-015306-us58wwmp 171 8 - - HYPH cord-015306-us58wwmp 171 9 II II NNP cord-015306-us58wwmp 171 10 ) ) -RRB- cord-015306-us58wwmp 171 11 VUR VUR NNP cord-015306-us58wwmp 171 12 and and CC cord-015306-us58wwmp 171 13 those those DT cord-015306-us58wwmp 171 14 who who WP cord-015306-us58wwmp 171 15 showed show VBD cord-015306-us58wwmp 171 16 normal normal JJ cord-015306-us58wwmp 171 17 DMSA DMSA NNS cord-015306-us58wwmp 171 18 findings finding NNS cord-015306-us58wwmp 171 19 were be VBD cord-015306-us58wwmp 171 20 included include VBN cord-015306-us58wwmp 171 21 into into IN cord-015306-us58wwmp 171 22 the the DT cord-015306-us58wwmp 171 23 study study NN cord-015306-us58wwmp 171 24 . . . cord-015306-us58wwmp 172 1 Initially initially RB cord-015306-us58wwmp 172 2 , , , cord-015306-us58wwmp 172 3 a a DT cord-015306-us58wwmp 172 4 DMSA DMSA NNP cord-015306-us58wwmp 172 5 scintigraphy scintigraphy NN cord-015306-us58wwmp 172 6 was be VBD cord-015306-us58wwmp 172 7 performed perform VBN cord-015306-us58wwmp 172 8 in in IN cord-015306-us58wwmp 172 9 all all DT cord-015306-us58wwmp 172 10 patients patient NNS cord-015306-us58wwmp 172 11 and and CC cord-015306-us58wwmp 172 12 those those DT cord-015306-us58wwmp 172 13 who who WP cord-015306-us58wwmp 172 14 experienced experience VBD cord-015306-us58wwmp 172 15 acute acute JJ cord-015306-us58wwmp 172 16 febrile febrile JJ cord-015306-us58wwmp 172 17 urinary urinary JJ cord-015306-us58wwmp 172 18 tract tract NN cord-015306-us58wwmp 172 19 infection infection NN cord-015306-us58wwmp 172 20 ( ( -LRB- cord-015306-us58wwmp 172 21 UTI UTI NNP cord-015306-us58wwmp 172 22 ) ) -RRB- cord-015306-us58wwmp 172 23 during during IN cord-015306-us58wwmp 172 24 the the DT cord-015306-us58wwmp 172 25 follow follow NN cord-015306-us58wwmp 172 26 - - HYPH cord-015306-us58wwmp 172 27 up up NN cord-015306-us58wwmp 172 28 period period NN cord-015306-us58wwmp 172 29 . . . cord-015306-us58wwmp 173 1 Treatment treatment NN cord-015306-us58wwmp 173 2 success success NN cord-015306-us58wwmp 173 3 was be VBD cord-015306-us58wwmp 173 4 defined define VBN cord-015306-us58wwmp 173 5 as as IN cord-015306-us58wwmp 173 6 complete complete JJ cord-015306-us58wwmp 173 7 VUR VUR NNP cord-015306-us58wwmp 173 8 resolution resolution NN cord-015306-us58wwmp 173 9 . . . cord-015306-us58wwmp 174 1 No no DT cord-015306-us58wwmp 174 2 patients patient NNS cord-015306-us58wwmp 174 3 were be VBD cord-015306-us58wwmp 174 4 prescribed prescribe VBN cord-015306-us58wwmp 174 5 antibiotic antibiotic JJ cord-015306-us58wwmp 174 6 prophylaxis prophylaxis NN cord-015306-us58wwmp 174 7 . . . cord-015306-us58wwmp 175 1 All all DT cord-015306-us58wwmp 175 2 parents parent NNS cord-015306-us58wwmp 175 3 were be VBD cord-015306-us58wwmp 175 4 informed inform VBN cord-015306-us58wwmp 175 5 by by IN cord-015306-us58wwmp 175 6 being be VBG cord-015306-us58wwmp 175 7 given give VBN cord-015306-us58wwmp 175 8 an an DT cord-015306-us58wwmp 175 9 explanation explanation NN cord-015306-us58wwmp 175 10 of of IN cord-015306-us58wwmp 175 11 the the DT cord-015306-us58wwmp 175 12 clinical clinical JJ cord-015306-us58wwmp 175 13 significance significance NN cord-015306-us58wwmp 175 14 of of IN cord-015306-us58wwmp 175 15 personal personal JJ cord-015306-us58wwmp 175 16 hygiene hygiene NN cord-015306-us58wwmp 175 17 methods method NNS cord-015306-us58wwmp 175 18 used use VBN cord-015306-us58wwmp 175 19 after after IN cord-015306-us58wwmp 175 20 urinating urinate VBG cord-015306-us58wwmp 175 21 or or CC cord-015306-us58wwmp 175 22 defecating defecating NN cord-015306-us58wwmp 175 23 . . . cord-015306-us58wwmp 176 1 Our -PRON- PRP$ cord-015306-us58wwmp 176 2 Institutional Institutional NNP cord-015306-us58wwmp 176 3 Review Review NNP cord-015306-us58wwmp 176 4 Board Board NNP cord-015306-us58wwmp 176 5 approved approve VBD cord-015306-us58wwmp 176 6 to to TO cord-015306-us58wwmp 176 7 collect collect VB cord-015306-us58wwmp 176 8 the the DT cord-015306-us58wwmp 176 9 data datum NNS cord-015306-us58wwmp 176 10 , , , cord-015306-us58wwmp 176 11 retrospectively retrospectively RB cord-015306-us58wwmp 176 12 . . . cord-015306-us58wwmp 177 1 Statistical statistical JJ cord-015306-us58wwmp 177 2 analysis analysis NN cord-015306-us58wwmp 177 3 was be VBD cord-015306-us58wwmp 177 4 made make VBN cord-015306-us58wwmp 177 5 by by IN cord-015306-us58wwmp 177 6 using use VBG cord-015306-us58wwmp 177 7 IBM IBM NNP cord-015306-us58wwmp 177 8 SPSS SPSS NNP cord-015306-us58wwmp 177 9 20.0 20.0 CD cord-015306-us58wwmp 177 10 software software NN cord-015306-us58wwmp 177 11 . . . cord-015306-us58wwmp 178 1 Results result NNS cord-015306-us58wwmp 178 2 : : : cord-015306-us58wwmp 179 1 The the DT cord-015306-us58wwmp 179 2 study study NN cord-015306-us58wwmp 179 3 sample sample NN cord-015306-us58wwmp 179 4 comprised comprise VBD cord-015306-us58wwmp 179 5 21 21 CD cord-015306-us58wwmp 179 6 infants infant NNS cord-015306-us58wwmp 179 7 ( ( -LRB- cord-015306-us58wwmp 179 8 10 10 CD cord-015306-us58wwmp 179 9 boys boy NNS cord-015306-us58wwmp 179 10 and and CC cord-015306-us58wwmp 179 11 11 11 CD cord-015306-us58wwmp 179 12 girls girl NNS cord-015306-us58wwmp 179 13 ) ) -RRB- cord-015306-us58wwmp 179 14 all all DT cord-015306-us58wwmp 179 15 of of IN cord-015306-us58wwmp 179 16 whom whom WP cord-015306-us58wwmp 179 17 showed show VBD cord-015306-us58wwmp 179 18 low low JJ cord-015306-us58wwmp 179 19 - - HYPH cord-015306-us58wwmp 179 20 grade grade NN cord-015306-us58wwmp 179 21 reflux reflux NN cord-015306-us58wwmp 179 22 ( ( -LRB- cord-015306-us58wwmp 179 23 grades grade NNS cord-015306-us58wwmp 179 24 I I NNP cord-015306-us58wwmp 179 25 - - HYPH cord-015306-us58wwmp 179 26 II II NNP cord-015306-us58wwmp 179 27 ) ) -RRB- cord-015306-us58wwmp 179 28 . . . cord-015306-us58wwmp 180 1 Bilateral bilateral JJ cord-015306-us58wwmp 180 2 reflux reflux NN cord-015306-us58wwmp 180 3 was be VBD cord-015306-us58wwmp 180 4 seen see VBN cord-015306-us58wwmp 180 5 in in IN cord-015306-us58wwmp 180 6 7 7 CD cord-015306-us58wwmp 180 7 ( ( -LRB- cord-015306-us58wwmp 180 8 33.3 33.3 CD cord-015306-us58wwmp 180 9 % % NN cord-015306-us58wwmp 180 10 ) ) -RRB- cord-015306-us58wwmp 180 11 of of IN cord-015306-us58wwmp 180 12 cases case NNS cord-015306-us58wwmp 180 13 . . . cord-015306-us58wwmp 181 1 Median median JJ cord-015306-us58wwmp 181 2 age age NN cord-015306-us58wwmp 181 3 at at IN cord-015306-us58wwmp 181 4 diagnosis diagnosis NN cord-015306-us58wwmp 181 5 was be VBD cord-015306-us58wwmp 181 6 8 8 CD cord-015306-us58wwmp 181 7 months month NNS cord-015306-us58wwmp 182 1 ( ( -LRB- cord-015306-us58wwmp 182 2 range range NN cord-015306-us58wwmp 182 3 : : : cord-015306-us58wwmp 182 4 1 1 CD cord-015306-us58wwmp 182 5 - - SYM cord-015306-us58wwmp 182 6 37 37 CD cord-015306-us58wwmp 182 7 months month NNS cord-015306-us58wwmp 182 8 ) ) -RRB- cord-015306-us58wwmp 182 9 . . . cord-015306-us58wwmp 183 1 Median median JJ cord-015306-us58wwmp 183 2 follow follow NN cord-015306-us58wwmp 183 3 - - HYPH cord-015306-us58wwmp 183 4 up up RP cord-015306-us58wwmp 183 5 time time NN cord-015306-us58wwmp 183 6 was be VBD cord-015306-us58wwmp 183 7 14 14 CD cord-015306-us58wwmp 183 8 months month NNS cord-015306-us58wwmp 184 1 ( ( -LRB- cord-015306-us58wwmp 184 2 range range NN cord-015306-us58wwmp 184 3 : : : cord-015306-us58wwmp 184 4 9 9 CD cord-015306-us58wwmp 184 5 - - SYM cord-015306-us58wwmp 184 6 28 28 CD cord-015306-us58wwmp 184 7 months month NNS cord-015306-us58wwmp 184 8 ) ) -RRB- cord-015306-us58wwmp 184 9 . . . cord-015306-us58wwmp 185 1 The the DT cord-015306-us58wwmp 185 2 spontaneousresolution spontaneousresolution NN cord-015306-us58wwmp 185 3 rate rate NN cord-015306-us58wwmp 185 4 of of IN cord-015306-us58wwmp 185 5 reflux reflux NN cord-015306-us58wwmp 185 6 was be VBD cord-015306-us58wwmp 185 7 89.3 89.3 CD cord-015306-us58wwmp 185 8 % % NN cord-015306-us58wwmp 185 9 ( ( -LRB- cord-015306-us58wwmp 185 10 25 25 CD cord-015306-us58wwmp 185 11 out out IN cord-015306-us58wwmp 185 12 of of IN cord-015306-us58wwmp 185 13 28 28 CD cord-015306-us58wwmp 185 14 renal renal JJ cord-015306-us58wwmp 185 15 units unit NNS cord-015306-us58wwmp 185 16 ) ) -RRB- cord-015306-us58wwmp 185 17 . . . cord-015306-us58wwmp 186 1 The the DT cord-015306-us58wwmp 186 2 frequency frequency NN cord-015306-us58wwmp 186 3 of of IN cord-015306-us58wwmp 186 4 febrile febrile JJ cord-015306-us58wwmp 186 5 UTI UTI NNP cord-015306-us58wwmp 186 6 was be VBD cord-015306-us58wwmp 186 7 0.74±0.7 0.74±0.7 CD cord-015306-us58wwmp 186 8 episode episode NN cord-015306-us58wwmp 186 9 / / SYM cord-015306-us58wwmp 186 10 year year NN cord-015306-us58wwmp 186 11 ( ( -LRB- cord-015306-us58wwmp 186 12 median median NN cord-015306-us58wwmp 186 13 : : : cord-015306-us58wwmp 186 14 0.8 0.8 CD cord-015306-us58wwmp 186 15 episode episode NN cord-015306-us58wwmp 186 16 / / SYM cord-015306-us58wwmp 186 17 year year NN cord-015306-us58wwmp 186 18 ) ) -RRB- cord-015306-us58wwmp 186 19 . . . cord-015306-us58wwmp 187 1 During during IN cord-015306-us58wwmp 187 2 the the DT cord-015306-us58wwmp 187 3 follow follow NN cord-015306-us58wwmp 187 4 - - HYPH cord-015306-us58wwmp 187 5 up up NN cord-015306-us58wwmp 187 6 no no DT cord-015306-us58wwmp 187 7 patients patient NNS cord-015306-us58wwmp 187 8 with with IN cord-015306-us58wwmp 187 9 febrile febrile JJ cord-015306-us58wwmp 187 10 UTI UTI NNP cord-015306-us58wwmp 187 11 experienced experience VBD cord-015306-us58wwmp 187 12 scar scar NN cord-015306-us58wwmp 187 13 on on IN cord-015306-us58wwmp 187 14 DMSA DMSA NNP cord-015306-us58wwmp 187 15 scintigraphy scintigraphy NNP cord-015306-us58wwmp 187 16 . . . cord-015306-us58wwmp 188 1 Conclusion conclusion NN cord-015306-us58wwmp 188 2 : : : cord-015306-us58wwmp 189 1 Infants infant NNS cord-015306-us58wwmp 189 2 with with IN cord-015306-us58wwmp 189 3 low low JJ cord-015306-us58wwmp 189 4 - - HYPH cord-015306-us58wwmp 189 5 grade grade NN cord-015306-us58wwmp 189 6 reflux reflux NN cord-015306-us58wwmp 189 7 show show VBP cord-015306-us58wwmp 189 8 a a DT cord-015306-us58wwmp 189 9 low low JJ cord-015306-us58wwmp 189 10 risk risk NN cord-015306-us58wwmp 189 11 of of IN cord-015306-us58wwmp 189 12 febrile febrile JJ cord-015306-us58wwmp 189 13 UTI UTI NNP cord-015306-us58wwmp 189 14 and and CC cord-015306-us58wwmp 189 15 a a DT cord-015306-us58wwmp 189 16 high high JJ cord-015306-us58wwmp 189 17 spontaneous spontaneous JJ cord-015306-us58wwmp 189 18 resolution resolution NN cord-015306-us58wwmp 189 19 rate rate NN cord-015306-us58wwmp 189 20 without without IN cord-015306-us58wwmp 189 21 antibiotic antibiotic JJ cord-015306-us58wwmp 189 22 prophylaxis prophylaxis NN cord-015306-us58wwmp 189 23 . . . cord-015306-us58wwmp 190 1 Therefore therefore RB cord-015306-us58wwmp 190 2 , , , cord-015306-us58wwmp 190 3 these these DT cord-015306-us58wwmp 190 4 children child NNS cord-015306-us58wwmp 190 5 should should MD cord-015306-us58wwmp 190 6 be be VB cord-015306-us58wwmp 190 7 managed manage VBN cord-015306-us58wwmp 190 8 primarily primarily RB cord-015306-us58wwmp 190 9 by by IN cord-015306-us58wwmp 190 10 conservative conservative JJ cord-015306-us58wwmp 190 11 therapy therapy NN cord-015306-us58wwmp 190 12 . . . cord-015306-us58wwmp 191 1 Ji Ji NNP cord-015306-us58wwmp 191 2 - - HYPH cord-015306-us58wwmp 191 3 Nan Nan NNP cord-015306-us58wwmp 191 4 Sheu Sheu NNP cord-015306-us58wwmp 191 5 1,2 1,2 CD cord-015306-us58wwmp 192 1 , , , cord-015306-us58wwmp 192 2 Hai Hai NNP cord-015306-us58wwmp 192 3 - - HYPH cord-015306-us58wwmp 192 4 Lun Lun NNP cord-015306-us58wwmp 192 5 Sun Sun NNP cord-015306-us58wwmp 192 6 1 1 CD cord-015306-us58wwmp 192 7 , , , cord-015306-us58wwmp 192 8 2 2 CD cord-015306-us58wwmp 192 9 , , , cord-015306-us58wwmp 192 10 Shan Shan NNP cord-015306-us58wwmp 192 11 - - HYPH cord-015306-us58wwmp 192 12 Ming Ming NNP cord-015306-us58wwmp 192 13 Chen Chen NNP cord-015306-us58wwmp 192 14 1 1 CD cord-015306-us58wwmp 192 15 , , , cord-015306-us58wwmp 192 16 2 2 CD cord-015306-us58wwmp 192 17 , , , cord-015306-us58wwmp 192 18 Yu Yu NNP cord-015306-us58wwmp 192 19 - - HYPH cord-015306-us58wwmp 192 20 Hua Hua NNP cord-015306-us58wwmp 192 21 Chao Chao NNP cord-015306-us58wwmp 192 22 1 1 CD cord-015306-us58wwmp 192 23 , , , cord-015306-us58wwmp 192 24 2 2 CD cord-015306-us58wwmp 192 25 , , , cord-015306-us58wwmp 193 1 Min Min NNP cord-015306-us58wwmp 193 2 - - HYPH cord-015306-us58wwmp 193 3 Sho Sho NNP cord-015306-us58wwmp 193 4 Ku Ku NNP cord-015306-us58wwmp 193 5 1 1 CD cord-015306-us58wwmp 193 6 , , , cord-015306-us58wwmp 193 7 2 2 CD cord-015306-us58wwmp 193 8 , , , cord-015306-us58wwmp 193 9 Pen Pen NNP cord-015306-us58wwmp 193 10 - - HYPH cord-015306-us58wwmp 193 11 Fen Fen NNP cord-015306-us58wwmp 193 12 Liao Liao NNP cord-015306-us58wwmp 193 13 1 1 CD cord-015306-us58wwmp 193 14 , , , cord-015306-us58wwmp 193 15 Ko Ko NNP cord-015306-us58wwmp 193 16 - - HYPH cord-015306-us58wwmp 193 17 Huang Huang NNP cord-015306-us58wwmp 193 18 Lue Lue NNP cord-015306-us58wwmp 193 19 1 1 CD cord-015306-us58wwmp 193 20 , , , cord-015306-us58wwmp 193 21 2 2 CD cord-015306-us58wwmp 193 22 1 1 CD cord-015306-us58wwmp 193 23 Pediatrics Pediatrics NNP cord-015306-us58wwmp 193 24 , , , cord-015306-us58wwmp 193 25 Chung Chung NNP cord-015306-us58wwmp 193 26 Shan Shan NNP cord-015306-us58wwmp 193 27 Medical Medical NNP cord-015306-us58wwmp 193 28 Unversity Unversity NNP cord-015306-us58wwmp 193 29 Hospital Hospital NNP cord-015306-us58wwmp 193 30 , , , cord-015306-us58wwmp 193 31 Taichung Taichung NNP cord-015306-us58wwmp 193 32 , , , cord-015306-us58wwmp 193 33 Taiwan Taiwan NNP cord-015306-us58wwmp 193 34 2 2 CD cord-015306-us58wwmp 193 35 School School NNP cord-015306-us58wwmp 193 36 of of IN cord-015306-us58wwmp 193 37 Medicine Medicine NNP cord-015306-us58wwmp 193 38 , , , cord-015306-us58wwmp 193 39 Chung Chung NNP cord-015306-us58wwmp 193 40 Shan Shan NNP cord-015306-us58wwmp 193 41 Medical Medical NNP cord-015306-us58wwmp 193 42 University University NNP cord-015306-us58wwmp 193 43 Taichung Taichung NNP cord-015306-us58wwmp 193 44 , , , cord-015306-us58wwmp 194 1 Taiwan Taiwan NNP cord-015306-us58wwmp 194 2 Objective Objective NNP cord-015306-us58wwmp 194 3 : : : cord-015306-us58wwmp 195 1 To to TO cord-015306-us58wwmp 195 2 assess assess VB cord-015306-us58wwmp 195 3 the the DT cord-015306-us58wwmp 195 4 usefulness usefulness NN cord-015306-us58wwmp 195 5 of of IN cord-015306-us58wwmp 195 6 procalcitonin procalcitonin NNS cord-015306-us58wwmp 195 7 ( ( -LRB- cord-015306-us58wwmp 195 8 PCT PCT NNP cord-015306-us58wwmp 195 9 ) ) -RRB- cord-015306-us58wwmp 195 10 as as IN cord-015306-us58wwmp 195 11 a a DT cord-015306-us58wwmp 195 12 marker marker NN cord-015306-us58wwmp 195 13 for for IN cord-015306-us58wwmp 195 14 predicting predict VBG cord-015306-us58wwmp 195 15 dilating dilate VBG cord-015306-us58wwmp 195 16 ( ( -LRB- cord-015306-us58wwmp 195 17 grades grade NNS cord-015306-us58wwmp 195 18 III III NNP cord-015306-us58wwmp 195 19 - - HYPH cord-015306-us58wwmp 195 20 V v NN cord-015306-us58wwmp 195 21 ) ) -RRB- cord-015306-us58wwmp 196 1 vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 196 2 reflux reflux NN cord-015306-us58wwmp 196 3 ( ( -LRB- cord-015306-us58wwmp 196 4 VUR VUR NNP cord-015306-us58wwmp 196 5 ) ) -RRB- cord-015306-us58wwmp 196 6 in in IN cord-015306-us58wwmp 196 7 young young JJ cord-015306-us58wwmp 196 8 children child NNS cord-015306-us58wwmp 196 9 with with IN cord-015306-us58wwmp 196 10 a a DT cord-015306-us58wwmp 196 11 first first JJ cord-015306-us58wwmp 196 12 febrile febrile JJ cord-015306-us58wwmp 196 13 urinary urinary JJ cord-015306-us58wwmp 196 14 tract tract NN cord-015306-us58wwmp 196 15 infection infection NN cord-015306-us58wwmp 196 16 ( ( -LRB- cord-015306-us58wwmp 196 17 UTI UTI NNP cord-015306-us58wwmp 196 18 ) ) -RRB- cord-015306-us58wwmp 196 19 . . . cord-015306-us58wwmp 197 1 Methods method NNS cord-015306-us58wwmp 197 2 : : : cord-015306-us58wwmp 197 3 Children child NNS cord-015306-us58wwmp 197 4 aged≤ aged≤ NNP cord-015306-us58wwmp 197 5 2 2 CD cord-015306-us58wwmp 197 6 years year NNS cord-015306-us58wwmp 197 7 old old JJ cord-015306-us58wwmp 197 8 with with IN cord-015306-us58wwmp 197 9 a a DT cord-015306-us58wwmp 197 10 first first JJ cord-015306-us58wwmp 197 11 febrile febrile JJ cord-015306-us58wwmp 197 12 UTI UTI NNP cord-015306-us58wwmp 197 13 were be VBD cord-015306-us58wwmp 197 14 prospectively prospectively RB cord-015306-us58wwmp 197 15 evaluated evaluate VBN cord-015306-us58wwmp 197 16 . . . cord-015306-us58wwmp 198 1 Serum serum NN cord-015306-us58wwmp 198 2 samples sample NNS cord-015306-us58wwmp 198 3 were be VBD cord-015306-us58wwmp 198 4 tested test VBN cord-015306-us58wwmp 198 5 for for IN cord-015306-us58wwmp 198 6 PCT pct NN cord-015306-us58wwmp 198 7 measurements measurement NNS cord-015306-us58wwmp 198 8 upon upon IN cord-015306-us58wwmp 198 9 admission admission NN cord-015306-us58wwmp 198 10 to to IN cord-015306-us58wwmp 198 11 a a DT cord-015306-us58wwmp 198 12 tertiary tertiary JJ cord-015306-us58wwmp 198 13 hospital hospital NN cord-015306-us58wwmp 198 14 . . . cord-015306-us58wwmp 199 1 All all DT cord-015306-us58wwmp 199 2 children child NNS cord-015306-us58wwmp 199 3 underwent undergo VBD cord-015306-us58wwmp 199 4 renal renal JJ cord-015306-us58wwmp 199 5 ultrasonography ultrasonography NN cord-015306-us58wwmp 199 6 ( ( -LRB- cord-015306-us58wwmp 199 7 US US NNP cord-015306-us58wwmp 199 8 ) ) -RRB- cord-015306-us58wwmp 199 9 , , , cord-015306-us58wwmp 199 10 99 99 CD cord-015306-us58wwmp 199 11 m m NNP cord-015306-us58wwmp 199 12 Tc Tc NNP cord-015306-us58wwmp 199 13 - - HYPH cord-015306-us58wwmp 199 14 dimercaptosuccinic dimercaptosuccinic JJ cord-015306-us58wwmp 199 15 acid acid NN cord-015306-us58wwmp 199 16 renal renal JJ cord-015306-us58wwmp 199 17 scan scan NN cord-015306-us58wwmp 199 18 , , , cord-015306-us58wwmp 199 19 and and CC cord-015306-us58wwmp 199 20 voiding void VBG cord-015306-us58wwmp 199 21 cystourethrography cystourethrography NNP cord-015306-us58wwmp 199 22 . . . cord-015306-us58wwmp 200 1 The the DT cord-015306-us58wwmp 200 2 diagnostic diagnostic JJ cord-015306-us58wwmp 200 3 characteristics characteristic NNS cord-015306-us58wwmp 200 4 of of IN cord-015306-us58wwmp 200 5 PCT PCT NNP cord-015306-us58wwmp 200 6 test test NN cord-015306-us58wwmp 200 7 for for IN cord-015306-us58wwmp 200 8 acute acute JJ cord-015306-us58wwmp 200 9 pyelonephritis pyelonephritis NN cord-015306-us58wwmp 200 10 ( ( -LRB- cord-015306-us58wwmp 200 11 APN APN NNP cord-015306-us58wwmp 200 12 ) ) -RRB- cord-015306-us58wwmp 200 13 and and CC cord-015306-us58wwmp 200 14 dilating dilate VBG cord-015306-us58wwmp 200 15 VUR VUR NNP cord-015306-us58wwmp 200 16 were be VBD cord-015306-us58wwmp 200 17 calculated calculate VBN cord-015306-us58wwmp 200 18 . . . cord-015306-us58wwmp 201 1 Results result NNS cord-015306-us58wwmp 201 2 : : : cord-015306-us58wwmp 202 1 Of of IN cord-015306-us58wwmp 202 2 272 272 CD cord-015306-us58wwmp 202 3 children child NNS cord-015306-us58wwmp 202 4 analyzed analyze VBN cord-015306-us58wwmp 202 5 ( ( -LRB- cord-015306-us58wwmp 202 6 168 168 CD cord-015306-us58wwmp 202 7 boys boy NNS cord-015306-us58wwmp 202 8 and and CC cord-015306-us58wwmp 202 9 104 104 CD cord-015306-us58wwmp 202 10 girls girl NNS cord-015306-us58wwmp 202 11 ; ; : cord-015306-us58wwmp 202 12 median median JJ cord-015306-us58wwmp 202 13 age age NN cord-015306-us58wwmp 202 14 , , , cord-015306-us58wwmp 202 15 5 5 CD cord-015306-us58wwmp 202 16 months month NNS cord-015306-us58wwmp 202 17 ) ) -RRB- cord-015306-us58wwmp 202 18 , , , cord-015306-us58wwmp 202 19 169 169 CD cord-015306-us58wwmp 202 20 ( ( -LRB- cord-015306-us58wwmp 202 21 62.1 62.1 CD cord-015306-us58wwmp 202 22 % % NN cord-015306-us58wwmp 202 23 ) ) -RRB- cord-015306-us58wwmp 202 24 had have VBD cord-015306-us58wwmp 202 25 APN APN NNP cord-015306-us58wwmp 202 26 . . . cord-015306-us58wwmp 203 1 There there EX cord-015306-us58wwmp 203 2 was be VBD cord-015306-us58wwmp 203 3 VUR VUR NNP cord-015306-us58wwmp 203 4 in in IN cord-015306-us58wwmp 203 5 97 97 CD cord-015306-us58wwmp 203 6 ( ( -LRB- cord-015306-us58wwmp 203 7 35.7 35.7 CD cord-015306-us58wwmp 203 8 % % NN cord-015306-us58wwmp 203 9 ) ) -RRB- cord-015306-us58wwmp 203 10 , , , cord-015306-us58wwmp 203 11 including include VBG cord-015306-us58wwmp 203 12 70 70 CD cord-015306-us58wwmp 203 13 ( ( -LRB- cord-015306-us58wwmp 203 14 25.7 25.7 CD cord-015306-us58wwmp 203 15 % % NN cord-015306-us58wwmp 203 16 ) ) -RRB- cord-015306-us58wwmp 203 17 with with IN cord-015306-us58wwmp 203 18 dilating dilate VBG cord-015306-us58wwmp 203 19 VUR VUR NNP cord-015306-us58wwmp 203 20 . . . cord-015306-us58wwmp 204 1 The the DT cord-015306-us58wwmp 204 2 median median JJ cord-015306-us58wwmp 204 3 PCT PCT NNP cord-015306-us58wwmp 204 4 value value NN cord-015306-us58wwmp 204 5 was be VBD cord-015306-us58wwmp 204 6 significantly significantly RB cord-015306-us58wwmp 204 7 higher high JJR cord-015306-us58wwmp 204 8 in in IN cord-015306-us58wwmp 204 9 children child NNS cord-015306-us58wwmp 204 10 with with IN cord-015306-us58wwmp 204 11 VUR VUR NNP cord-015306-us58wwmp 204 12 than than IN cord-015306-us58wwmp 204 13 in in IN cord-015306-us58wwmp 204 14 those those DT cord-015306-us58wwmp 204 15 without without IN cord-015306-us58wwmp 204 16 ( ( -LRB- cord-015306-us58wwmp 204 17 P p NN cord-015306-us58wwmp 204 18 < < XX cord-015306-us58wwmp 204 19 0.001 0.001 CD cord-015306-us58wwmp 204 20 ) ) -RRB- cord-015306-us58wwmp 204 21 . . . cord-015306-us58wwmp 205 1 Using use VBG cord-015306-us58wwmp 205 2 a a DT cord-015306-us58wwmp 205 3 PCT PCT NNP cord-015306-us58wwmp 205 4 cutoff cutoff NN cord-015306-us58wwmp 205 5 value value NN cord-015306-us58wwmp 205 6 of of IN cord-015306-us58wwmp 205 7 ≥1.0ng ≥1.0ng NNP cord-015306-us58wwmp 205 8 / / SYM cord-015306-us58wwmp 205 9 mL ml NN cord-015306-us58wwmp 205 10 , , , cord-015306-us58wwmp 205 11 the the DT cord-015306-us58wwmp 205 12 sensitivity sensitivity NN cord-015306-us58wwmp 205 13 and and CC cord-015306-us58wwmp 205 14 negative negative JJ cord-015306-us58wwmp 205 15 predictive predictive JJ cord-015306-us58wwmp 205 16 value value NN cord-015306-us58wwmp 205 17 for for IN cord-015306-us58wwmp 205 18 predicting predict VBG cord-015306-us58wwmp 205 19 dilating dilate VBG cord-015306-us58wwmp 205 20 VUR VUR NNP cord-015306-us58wwmp 205 21 were be VBD cord-015306-us58wwmp 205 22 94.3 94.3 CD cord-015306-us58wwmp 205 23 % % NN cord-015306-us58wwmp 205 24 and and CC cord-015306-us58wwmp 205 25 95.4 95.4 CD cord-015306-us58wwmp 205 26 % % NN cord-015306-us58wwmp 205 27 , , , cord-015306-us58wwmp 205 28 respectively respectively RB cord-015306-us58wwmp 205 29 , , , cord-015306-us58wwmp 205 30 for for IN cord-015306-us58wwmp 205 31 PCT PCT NNP cord-015306-us58wwmp 205 32 , , , cord-015306-us58wwmp 205 33 and and CC cord-015306-us58wwmp 205 34 97.1 97.1 CD cord-015306-us58wwmp 205 35 % % NN cord-015306-us58wwmp 205 36 and and CC cord-015306-us58wwmp 205 37 97.8 97.8 CD cord-015306-us58wwmp 205 38 % % NN cord-015306-us58wwmp 205 39 , , , cord-015306-us58wwmp 205 40 respectively respectively RB cord-015306-us58wwmp 205 41 , , , cord-015306-us58wwmp 205 42 for for IN cord-015306-us58wwmp 205 43 the the DT cord-015306-us58wwmp 205 44 combined combine VBN cord-015306-us58wwmp 205 45 PCT PCT NNP cord-015306-us58wwmp 205 46 and and CC cord-015306-us58wwmp 205 47 US US NNP cord-015306-us58wwmp 205 48 studies study NNS cord-015306-us58wwmp 205 49 , , , cord-015306-us58wwmp 205 50 whereas whereas IN cord-015306-us58wwmp 205 51 the the DT cord-015306-us58wwmp 205 52 positive positive JJ cord-015306-us58wwmp 205 53 and and CC cord-015306-us58wwmp 205 54 negative negative JJ cord-015306-us58wwmp 205 55 likelihood likelihood NN cord-015306-us58wwmp 205 56 ratios ratio NNS cord-015306-us58wwmp 205 57 were be VBD cord-015306-us58wwmp 205 58 2.03 2.03 CD cord-015306-us58wwmp 205 59 and and CC cord-015306-us58wwmp 205 60 0.107 0.107 CD cord-015306-us58wwmp 205 61 , , , cord-015306-us58wwmp 205 62 respectively respectively RB cord-015306-us58wwmp 205 63 , , , cord-015306-us58wwmp 205 64 for for IN cord-015306-us58wwmp 205 65 PCT PCT NNP cord-015306-us58wwmp 205 66 , , , cord-015306-us58wwmp 205 67 and and CC cord-015306-us58wwmp 205 68 1.72 1.72 CD cord-015306-us58wwmp 205 69 and and CC cord-015306-us58wwmp 205 70 0.067 0.067 CD cord-015306-us58wwmp 205 71 , , , cord-015306-us58wwmp 205 72 respectively respectively RB cord-015306-us58wwmp 205 73 , , , cord-015306-us58wwmp 205 74 for for IN cord-015306-us58wwmp 205 75 the the DT cord-015306-us58wwmp 205 76 combined combined JJ cord-015306-us58wwmp 205 77 studies study NNS cord-015306-us58wwmp 205 78 . . . cord-015306-us58wwmp 206 1 By by IN cord-015306-us58wwmp 206 2 multivariate multivariate JJ cord-015306-us58wwmp 206 3 analysis analysis NN cord-015306-us58wwmp 206 4 , , , cord-015306-us58wwmp 206 5 high high JJ cord-015306-us58wwmp 206 6 PCT PCT NNP cord-015306-us58wwmp 206 7 values value NNS cord-015306-us58wwmp 206 8 and and CC cord-015306-us58wwmp 206 9 abnormalities abnormality NNS cord-015306-us58wwmp 206 10 on on IN cord-015306-us58wwmp 206 11 US US NNP cord-015306-us58wwmp 206 12 were be VBD cord-015306-us58wwmp 206 13 independent independent JJ cord-015306-us58wwmp 206 14 predictors predictor NNS cord-015306-us58wwmp 206 15 of of IN cord-015306-us58wwmp 206 16 dilating dilate VBG cord-015306-us58wwmp 206 17 VUR VUR NNP cord-015306-us58wwmp 206 18 . . . cord-015306-us58wwmp 207 1 Conclusion conclusion NN cord-015306-us58wwmp 207 2 : : : cord-015306-us58wwmp 207 3 PCT PCT NNP cord-015306-us58wwmp 207 4 is be VBZ cord-015306-us58wwmp 207 5 useful useful JJ cord-015306-us58wwmp 207 6 for for IN cord-015306-us58wwmp 207 7 diagnosing diagnose VBG cord-015306-us58wwmp 207 8 APN APN NNP cord-015306-us58wwmp 207 9 and and CC cord-015306-us58wwmp 207 10 predicting predict VBG cord-015306-us58wwmp 207 11 dilating dilate VBG cord-015306-us58wwmp 207 12 VUR VUR NNP cord-015306-us58wwmp 207 13 in in IN cord-015306-us58wwmp 207 14 young young JJ cord-015306-us58wwmp 207 15 children child NNS cord-015306-us58wwmp 207 16 with with IN cord-015306-us58wwmp 207 17 a a DT cord-015306-us58wwmp 207 18 first first JJ cord-015306-us58wwmp 207 19 febrile febrile JJ cord-015306-us58wwmp 207 20 UTI UTI NNP cord-015306-us58wwmp 207 21 . . . cord-015306-us58wwmp 208 1 A a DT cord-015306-us58wwmp 208 2 voiding void VBG cord-015306-us58wwmp 208 3 cystourethrography cystourethrography NN cord-015306-us58wwmp 208 4 is be VBZ cord-015306-us58wwmp 208 5 indicated indicate VBN cord-015306-us58wwmp 208 6 only only RB cord-015306-us58wwmp 208 7 in in IN cord-015306-us58wwmp 208 8 children child NNS cord-015306-us58wwmp 208 9 with with IN cord-015306-us58wwmp 208 10 high high JJ cord-015306-us58wwmp 208 11 PCT PCT NNP cord-015306-us58wwmp 208 12 values value NNS cord-015306-us58wwmp 208 13 ( ( -LRB- cord-015306-us58wwmp 208 14 ≥1.0 ≥1.0 NNP cord-015306-us58wwmp 208 15 ng ng NNP cord-015306-us58wwmp 208 16 / / SYM cord-015306-us58wwmp 208 17 mL ml NN cord-015306-us58wwmp 208 18 ) ) -RRB- cord-015306-us58wwmp 209 1 and/or and/or CC cord-015306-us58wwmp 209 2 abnormalities abnormality NNS cord-015306-us58wwmp 209 3 found find VBN cord-015306-us58wwmp 209 4 on on IN cord-015306-us58wwmp 209 5 a a DT cord-015306-us58wwmp 209 6 US US NNP cord-015306-us58wwmp 209 7 . . . cord-015306-us58wwmp 210 1 Objective objective NN cord-015306-us58wwmp 210 2 : : : cord-015306-us58wwmp 211 1 To to TO cord-015306-us58wwmp 211 2 evaluate evaluate VB cord-015306-us58wwmp 211 3 the the DT cord-015306-us58wwmp 211 4 accuracy accuracy NN cord-015306-us58wwmp 211 5 of of IN cord-015306-us58wwmp 211 6 acute acute JJ cord-015306-us58wwmp 211 7 99 99 CD cord-015306-us58wwmp 211 8 m m NN cord-015306-us58wwmp 211 9 Tc Tc NNP cord-015306-us58wwmp 211 10 - - HYPH cord-015306-us58wwmp 211 11 dimercaptosuccinic dimercaptosuccinic JJ cord-015306-us58wwmp 211 12 acid acid NN cord-015306-us58wwmp 211 13 ( ( -LRB- cord-015306-us58wwmp 211 14 DMSA DMSA NNP cord-015306-us58wwmp 211 15 ) ) -RRB- cord-015306-us58wwmp 211 16 scan scan VBP cord-015306-us58wwmp 211 17 in in IN cord-015306-us58wwmp 211 18 predicting predict VBG cord-015306-us58wwmp 211 19 dilating dilate VBG cord-015306-us58wwmp 211 20 vesicoureteral vesicoureteral JJ cord-015306-us58wwmp 211 21 reflux reflux NN cord-015306-us58wwmp 211 22 ( ( -LRB- cord-015306-us58wwmp 211 23 VUR VUR NNP cord-015306-us58wwmp 211 24 ) ) -RRB- cord-015306-us58wwmp 211 25 among among IN cord-015306-us58wwmp 211 26 young young JJ cord-015306-us58wwmp 211 27 children child NNS cord-015306-us58wwmp 211 28 with with IN cord-015306-us58wwmp 211 29 febrile febrile JJ cord-015306-us58wwmp 211 30 urinary urinary JJ cord-015306-us58wwmp 211 31 tract tract NN cord-015306-us58wwmp 211 32 infection infection NN cord-015306-us58wwmp 211 33 ( ( -LRB- cord-015306-us58wwmp 211 34 UTI UTI NNP cord-015306-us58wwmp 211 35 ) ) -RRB- cord-015306-us58wwmp 211 36 . . . cord-015306-us58wwmp 212 1 Methods method NNS cord-015306-us58wwmp 212 2 : : : cord-015306-us58wwmp 213 1 The the DT cord-015306-us58wwmp 213 2 medical medical JJ cord-015306-us58wwmp 213 3 records record NNS cord-015306-us58wwmp 213 4 of of IN cord-015306-us58wwmp 213 5 children child NNS cord-015306-us58wwmp 213 6 ( ( -LRB- cord-015306-us58wwmp 213 7 age≤2 age≤2 NNP cord-015306-us58wwmp 213 8 years year NNS cord-015306-us58wwmp 213 9 ) ) -RRB- cord-015306-us58wwmp 213 10 , , , cord-015306-us58wwmp 213 11 presenting present VBG cord-015306-us58wwmp 213 12 with with IN cord-015306-us58wwmp 213 13 febrile febrile JJ cord-015306-us58wwmp 213 14 UTI UTI NNP cord-015306-us58wwmp 213 15 between between IN cord-015306-us58wwmp 213 16 January January NNP cord-015306-us58wwmp 213 17 2000 2000 CD cord-015306-us58wwmp 213 18 and and CC cord-015306-us58wwmp 213 19 December December NNP cord-015306-us58wwmp 213 20 2011 2011 CD cord-015306-us58wwmp 213 21 , , , cord-015306-us58wwmp 213 22 were be VBD cord-015306-us58wwmp 213 23 retrospectively retrospectively RB cord-015306-us58wwmp 213 24 reviewed review VBN cord-015306-us58wwmp 213 25 . . . cord-015306-us58wwmp 214 1 The the DT cord-015306-us58wwmp 214 2 sensitivity sensitivity NN cord-015306-us58wwmp 214 3 , , , cord-015306-us58wwmp 214 4 specificity specificity NN cord-015306-us58wwmp 214 5 , , , cord-015306-us58wwmp 214 6 positive positive JJ cord-015306-us58wwmp 214 7 and and CC cord-015306-us58wwmp 214 8 negative negative JJ cord-015306-us58wwmp 214 9 predictive predictive JJ cord-015306-us58wwmp 214 10 value value NN cord-015306-us58wwmp 214 11 , , , cord-015306-us58wwmp 214 12 positive positive JJ cord-015306-us58wwmp 214 13 and and CC cord-015306-us58wwmp 214 14 negative negative JJ cord-015306-us58wwmp 214 15 likelihood likelihood NN cord-015306-us58wwmp 214 16 ratio ratio NN cord-015306-us58wwmp 214 17 of of IN cord-015306-us58wwmp 214 18 acute acute JJ cord-015306-us58wwmp 214 19 DMSA DMSA NNS cord-015306-us58wwmp 214 20 scan scan VBP cord-015306-us58wwmp 214 21 in in IN cord-015306-us58wwmp 214 22 predicting predict VBG cord-015306-us58wwmp 214 23 dilating dilate VBG cord-015306-us58wwmp 214 24 VUR VUR NNP cord-015306-us58wwmp 214 25 in in IN cord-015306-us58wwmp 214 26 young young JJ cord-015306-us58wwmp 214 27 children child NNS cord-015306-us58wwmp 214 28 with with IN cord-015306-us58wwmp 214 29 febrile febrile JJ cord-015306-us58wwmp 214 30 UTI UTI NNP cord-015306-us58wwmp 214 31 were be VBD cord-015306-us58wwmp 214 32 calculated calculate VBN cord-015306-us58wwmp 214 33 . . . cord-015306-us58wwmp 215 1 Results result NNS cord-015306-us58wwmp 215 2 : : : cord-015306-us58wwmp 216 1 A a DT cord-015306-us58wwmp 216 2 total total NN cord-015306-us58wwmp 216 3 of of IN cord-015306-us58wwmp 216 4 523 523 CD cord-015306-us58wwmp 216 5 children child NNS cord-015306-us58wwmp 216 6 were be VBD cord-015306-us58wwmp 216 7 included include VBN cord-015306-us58wwmp 216 8 , , , cord-015306-us58wwmp 216 9 of of IN cord-015306-us58wwmp 216 10 which which WDT cord-015306-us58wwmp 216 11 397(75.9 397(75.9 CD cord-015306-us58wwmp 216 12 % % NN cord-015306-us58wwmp 216 13 ) ) -RRB- cord-015306-us58wwmp 216 14 had have VBD cord-015306-us58wwmp 216 15 abnormal abnormal JJ cord-015306-us58wwmp 216 16 DMSA DMSA NNS cord-015306-us58wwmp 216 17 results result NNS cord-015306-us58wwmp 216 18 and and CC cord-015306-us58wwmp 216 19 178(34.0 178(34.0 CD cord-015306-us58wwmp 216 20 % % NN cord-015306-us58wwmp 216 21 ) ) -RRB- cord-015306-us58wwmp 216 22 were be VBD cord-015306-us58wwmp 216 23 identified identify VBN cord-015306-us58wwmp 216 24 as as IN cord-015306-us58wwmp 216 25 VUR VUR NNP cord-015306-us58wwmp 216 26 on on IN cord-015306-us58wwmp 216 27 micturatingcystourethrography micturatingcystourethrography NNP cord-015306-us58wwmp 216 28 ( ( -LRB- cord-015306-us58wwmp 216 29 MCU MCU NNP cord-015306-us58wwmp 216 30 ) ) -RRB- cord-015306-us58wwmp 216 31 . . . cord-015306-us58wwmp 217 1 Among among IN cord-015306-us58wwmp 217 2 all all PDT cord-015306-us58wwmp 217 3 the the DT cord-015306-us58wwmp 217 4 patients patient NNS cord-015306-us58wwmp 217 5 , , , cord-015306-us58wwmp 217 6 the the DT cord-015306-us58wwmp 217 7 number number NN cord-015306-us58wwmp 217 8 of of IN cord-015306-us58wwmp 217 9 dilating dilate VBG cord-015306-us58wwmp 217 10 VUR VUR NNP cord-015306-us58wwmp 217 11 was be VBD cord-015306-us58wwmp 217 12 151(28.9 151(28.9 CD cord-015306-us58wwmp 217 13 % % NN cord-015306-us58wwmp 217 14 ) ) -RRB- cord-015306-us58wwmp 217 15 . . . cord-015306-us58wwmp 218 1 The the DT cord-015306-us58wwmp 218 2 rate rate NN cord-015306-us58wwmp 218 3 of of IN cord-015306-us58wwmp 218 4 abnormal abnormal JJ cord-015306-us58wwmp 218 5 results result NNS cord-015306-us58wwmp 218 6 on on IN cord-015306-us58wwmp 218 7 DMSA DMSA NNS cord-015306-us58wwmp 218 8 of of IN cord-015306-us58wwmp 218 9 dilating dilate VBG cord-015306-us58wwmp 218 10 VUR VUR NNP cord-015306-us58wwmp 218 11 group group NN cord-015306-us58wwmp 218 12 was be VBD cord-015306-us58wwmp 218 13 significantly significantly RB cord-015306-us58wwmp 218 14 higher high JJR cord-015306-us58wwmp 218 15 than than IN cord-015306-us58wwmp 218 16 the the DT cord-015306-us58wwmp 218 17 rates rate NNS cord-015306-us58wwmp 218 18 of of IN cord-015306-us58wwmp 218 19 non non JJ cord-015306-us58wwmp 218 20 - - JJ cord-015306-us58wwmp 218 21 VUR vur JJ cord-015306-us58wwmp 218 22 and and CC cord-015306-us58wwmp 218 23 low low JJ cord-015306-us58wwmp 218 24 - - HYPH cord-015306-us58wwmp 218 25 grade grade NN cord-015306-us58wwmp 218 26 VUR VUR NNP cord-015306-us58wwmp 218 27 groups group NNS cord-015306-us58wwmp 218 28 ( ( -LRB- cord-015306-us58wwmp 218 29 P<0.01 p<0.01 CD cord-015306-us58wwmp 218 30 ) ) -RRB- cord-015306-us58wwmp 218 31 . . . cord-015306-us58wwmp 219 1 In in IN cord-015306-us58wwmp 219 2 age<6 age<6 CD cord-015306-us58wwmp 219 3 months month NNS cord-015306-us58wwmp 219 4 group group NN cord-015306-us58wwmp 219 5 and and CC cord-015306-us58wwmp 219 6 age≥6 age≥6 NNP cord-015306-us58wwmp 219 7 months month NNS cord-015306-us58wwmp 219 8 group group NN cord-015306-us58wwmp 219 9 , , , cord-015306-us58wwmp 219 10 the the DT cord-015306-us58wwmp 219 11 sensitivities sensitivity NNS cord-015306-us58wwmp 219 12 of of IN cord-015306-us58wwmp 219 13 DMSA DMSA NNS cord-015306-us58wwmp 219 14 in in IN cord-015306-us58wwmp 219 15 predicting predict VBG cord-015306-us58wwmp 219 16 dilating dilate VBG cord-015306-us58wwmp 219 17 VUR VUR NNP cord-015306-us58wwmp 219 18 were be VBD cord-015306-us58wwmp 219 19 96.15 96.15 CD cord-015306-us58wwmp 219 20 % % NN cord-015306-us58wwmp 219 21 , , , cord-015306-us58wwmp 219 22 100.0 100.0 CD cord-015306-us58wwmp 219 23 % % NN cord-015306-us58wwmp 219 24 respectively respectively RB cord-015306-us58wwmp 219 25 , , , cord-015306-us58wwmp 219 26 while while IN cord-015306-us58wwmp 219 27 the the DT cord-015306-us58wwmp 219 28 negative negative JJ cord-015306-us58wwmp 219 29 predictive predictive JJ cord-015306-us58wwmp 219 30 value value NN cord-015306-us58wwmp 219 31 were be VBD cord-015306-us58wwmp 219 32 97.26 97.26 CD cord-015306-us58wwmp 219 33 % % NN cord-015306-us58wwmp 219 34 , , , cord-015306-us58wwmp 219 35 100.0 100.0 CD cord-015306-us58wwmp 219 36 % % NN cord-015306-us58wwmp 219 37 and and CC cord-015306-us58wwmp 219 38 negative negative JJ cord-015306-us58wwmp 219 39 likelihood likelihood NN cord-015306-us58wwmp 219 40 ratio ratio NN cord-015306-us58wwmp 219 41 were be VBD cord-015306-us58wwmp 219 42 0.0911,0.0000 0.0911,0.0000 CD cord-015306-us58wwmp 219 43 , , , cord-015306-us58wwmp 219 44 respectively respectively RB cord-015306-us58wwmp 219 45 . . . cord-015306-us58wwmp 220 1 Conclusion conclusion NN cord-015306-us58wwmp 220 2 : : : cord-015306-us58wwmp 220 3 For for IN cord-015306-us58wwmp 220 4 children child NNS cord-015306-us58wwmp 220 5 of of IN cord-015306-us58wwmp 220 6 age≤2 age≤2 NNP cord-015306-us58wwmp 220 7 years year NNS cord-015306-us58wwmp 220 8 with with IN cord-015306-us58wwmp 220 9 febrile febrile JJ cord-015306-us58wwmp 220 10 UTI UTI NNP cord-015306-us58wwmp 220 11 , , , cord-015306-us58wwmp 220 12 acute acute JJ cord-015306-us58wwmp 220 13 DMSA DMSA NNS cord-015306-us58wwmp 220 14 scan scan JJ cord-015306-us58wwmp 220 15 possesses possess VBZ cord-015306-us58wwmp 220 16 certain certain JJ cord-015306-us58wwmp 220 17 values value NNS cord-015306-us58wwmp 220 18 in in IN cord-015306-us58wwmp 220 19 excluding exclude VBG cord-015306-us58wwmp 220 20 dilating dilate VBG cord-015306-us58wwmp 220 21 VUR VUR NNP cord-015306-us58wwmp 220 22 . . . cord-015306-us58wwmp 221 1 The the DT cord-015306-us58wwmp 221 2 possibility possibility NN cord-015306-us58wwmp 221 3 to to TO cord-015306-us58wwmp 221 4 detect detect VB cord-015306-us58wwmp 221 5 dilating dilate VBG cord-015306-us58wwmp 221 6 VUR VUR NNP cord-015306-us58wwmp 221 7 by by IN cord-015306-us58wwmp 221 8 MCU MCU NNP cord-015306-us58wwmp 221 9 is be VBZ cord-015306-us58wwmp 221 10 rather rather RB cord-015306-us58wwmp 221 11 low low JJ cord-015306-us58wwmp 221 12 when when WRB cord-015306-us58wwmp 221 13 the the DT cord-015306-us58wwmp 221 14 result result NN cord-015306-us58wwmp 221 15 of of IN cord-015306-us58wwmp 221 16 DMSA DMSA NNP cord-015306-us58wwmp 221 17 is be VBZ cord-015306-us58wwmp 221 18 negative negative JJ cord-015306-us58wwmp 221 19 . . . cord-015306-us58wwmp 222 1 CAKUT CAKUT NNP cord-015306-us58wwmp 222 2 : : : cord-015306-us58wwmp 222 3 Voiding void VBG cord-015306-us58wwmp 222 4 disorders disorder NNS cord-015306-us58wwmp 222 5 Abstract abstract JJ cord-015306-us58wwmp 222 6 # # NN cord-015306-us58wwmp 222 7 P P NNP cord-015306-us58wwmp 222 8 - - HYPH cord-015306-us58wwmp 222 9 SAT048 SAT048 NNP cord-015306-us58wwmp 222 10 Mono mono NN cord-015306-us58wwmp 222 11 - - HYPH cord-015306-us58wwmp 222 12 symptomatic symptomatic JJ cord-015306-us58wwmp 222 13 and and CC cord-015306-us58wwmp 222 14 Non non JJ cord-015306-us58wwmp 222 15 - - JJ cord-015306-us58wwmp 222 16 mono mono JJ cord-015306-us58wwmp 222 17 symptomatic symptomatic JJ cord-015306-us58wwmp 222 18 Nocturnal Nocturnal NNP cord-015306-us58wwmp 222 19 Enuresis Enuresis NNP cord-015306-us58wwmp 222 20 : : : cord-015306-us58wwmp 223 1 A a DT cord-015306-us58wwmp 223 2 Clinical clinical JJ cord-015306-us58wwmp 223 3 Evaluation Evaluation NNP cord-015306-us58wwmp 223 4 Mitra Mitra NNP cord-015306-us58wwmp 223 5 Naseri Naseri NNP cord-015306-us58wwmp 223 6 1 1 CD cord-015306-us58wwmp 224 1 , , , cord-015306-us58wwmp 224 2 Mehran Mehran NNP cord-015306-us58wwmp 224 3 Hiradfar Hiradfar NNP cord-015306-us58wwmp 224 4 2 2 CD cord-015306-us58wwmp 224 5 1 1 CD cord-015306-us58wwmp 224 6 Dr Dr NNP cord-015306-us58wwmp 224 7 Sheikh Sheikh NNP cord-015306-us58wwmp 224 8 children child NNS cord-015306-us58wwmp 224 9 hospital hospital NN cord-015306-us58wwmp 224 10 / / SYM cord-015306-us58wwmp 224 11 pediatric pediatric JJ cord-015306-us58wwmp 224 12 nephrology nephrology NN cord-015306-us58wwmp 224 13 department department NN cord-015306-us58wwmp 224 14 , , , cord-015306-us58wwmp 224 15 Mashhad Mashhad NNP cord-015306-us58wwmp 224 16 University University NNP cord-015306-us58wwmp 224 17 of of IN cord-015306-us58wwmp 224 18 Medical Medical NNP cord-015306-us58wwmp 224 19 Sciences Sciences NNPS cord-015306-us58wwmp 224 20 , , , cord-015306-us58wwmp 224 21 Mashhad Mashhad NNP cord-015306-us58wwmp 224 22 , , , cord-015306-us58wwmp 224 23 Iran Iran NNP cord-015306-us58wwmp 224 24 2 2 CD cord-015306-us58wwmp 224 25 Dr Dr NNP cord-015306-us58wwmp 224 26 Sheikh Sheikh NNP cord-015306-us58wwmp 224 27 children child NNS cord-015306-us58wwmp 224 28 hospital hospital NN cord-015306-us58wwmp 224 29 / / SYM cord-015306-us58wwmp 224 30 pediatric pediatric JJ cord-015306-us58wwmp 224 31 surgery surgery NN cord-015306-us58wwmp 224 32 department department NN cord-015306-us58wwmp 224 33 , , , cord-015306-us58wwmp 224 34 Mashhad Mashhad NNP cord-015306-us58wwmp 224 35 University University NNP cord-015306-us58wwmp 224 36 of of IN cord-015306-us58wwmp 224 37 Medical Medical NNP cord-015306-us58wwmp 224 38 Sciences Sciences NNPS cord-015306-us58wwmp 224 39 , , , cord-015306-us58wwmp 224 40 Mashhad Mashhad NNP cord-015306-us58wwmp 224 41 , , , cord-015306-us58wwmp 225 1 Iran Iran NNP cord-015306-us58wwmp 225 2 Objective Objective NNP cord-015306-us58wwmp 225 3 : : : cord-015306-us58wwmp 226 1 Nocturnal nocturnal JJ cord-015306-us58wwmp 226 2 enuresis enuresis NN cord-015306-us58wwmp 226 3 is be VBZ cord-015306-us58wwmp 226 4 divided divide VBN cord-015306-us58wwmp 226 5 into into IN cord-015306-us58wwmp 226 6 mono mono JJ cord-015306-us58wwmp 226 7 - - HYPH cord-015306-us58wwmp 226 8 symptomatic symptomatic JJ cord-015306-us58wwmp 226 9 nocturnal nocturnal JJ cord-015306-us58wwmp 226 10 enuresis(MNE enuresis(mne CD cord-015306-us58wwmp 226 11 ) ) -RRB- cord-015306-us58wwmp 226 12 and and CC cord-015306-us58wwmp 226 13 non non JJ cord-015306-us58wwmp 226 14 mono mono JJ cord-015306-us58wwmp 226 15 - - HYPH cord-015306-us58wwmp 226 16 symptomatic symptomatic JJ cord-015306-us58wwmp 226 17 nocturnal nocturnal JJ cord-015306-us58wwmp 226 18 enuresis(NMNE).This enuresis(nmne).this DT cord-015306-us58wwmp 226 19 study study NN cord-015306-us58wwmp 226 20 was be VBD cord-015306-us58wwmp 226 21 conducted conduct VBN cord-015306-us58wwmp 226 22 to to TO cord-015306-us58wwmp 226 23 review review VB cord-015306-us58wwmp 226 24 clinical clinical JJ cord-015306-us58wwmp 226 25 and and CC cord-015306-us58wwmp 226 26 ultrasonography ultrasonography JJ cord-015306-us58wwmp 226 27 findings finding NNS cord-015306-us58wwmp 226 28 in in IN cord-015306-us58wwmp 226 29 enuretic enuretic JJ cord-015306-us58wwmp 226 30 children child NNS cord-015306-us58wwmp 226 31 , , , cord-015306-us58wwmp 226 32 and and CC cord-015306-us58wwmp 226 33 compare compare VB cord-015306-us58wwmp 226 34 organic organic JJ cord-015306-us58wwmp 226 35 and and CC cord-015306-us58wwmp 226 36 functional functional JJ cord-015306-us58wwmp 226 37 pathologies pathology NNS cord-015306-us58wwmp 226 38 of of IN cord-015306-us58wwmp 226 39 lower low JJR cord-015306-us58wwmp 226 40 urinary urinary JJ cord-015306-us58wwmp 226 41 tract tract NN cord-015306-us58wwmp 226 42 ( ( -LRB- cord-015306-us58wwmp 226 43 LUT LUT NNP cord-015306-us58wwmp 226 44 ) ) -RRB- cord-015306-us58wwmp 226 45 in in IN cord-015306-us58wwmp 226 46 children child NNS cord-015306-us58wwmp 226 47 with with IN cord-015306-us58wwmp 226 48 mono mono NN cord-015306-us58wwmp 226 49 - - HYPH cord-015306-us58wwmp 226 50 MNE MNE NNP cord-015306-us58wwmp 226 51 with with IN cord-015306-us58wwmp 226 52 those those DT cord-015306-us58wwmp 226 53 who who WP cord-015306-us58wwmp 226 54 have have VBP cord-015306-us58wwmp 226 55 NMNE NMNE NNP cord-015306-us58wwmp 226 56 . . . cord-015306-us58wwmp 227 1 Methods method NNS cord-015306-us58wwmp 227 2 : : : cord-015306-us58wwmp 227 3 111 111 CD cord-015306-us58wwmp 227 4 neurologically neurologically RB cord-015306-us58wwmp 227 5 normal normal JJ cord-015306-us58wwmp 227 6 children child NNS cord-015306-us58wwmp 227 7 with with IN cord-015306-us58wwmp 227 8 chief chief JJ cord-015306-us58wwmp 227 9 complaint complaint NN cord-015306-us58wwmp 227 10 of of IN cord-015306-us58wwmp 227 11 enuresis enuresis NN cord-015306-us58wwmp 227 12 enrolled enrol VBN cord-015306-us58wwmp 227 13 in in IN cord-015306-us58wwmp 227 14 the the DT cord-015306-us58wwmp 227 15 study study NN cord-015306-us58wwmp 227 16 including include VBG cord-015306-us58wwmp 227 17 60 60 CD cord-015306-us58wwmp 227 18 boys boy NNS cord-015306-us58wwmp 227 19 and and CC cord-015306-us58wwmp 227 20 51 51 CD cord-015306-us58wwmp 227 21 girls girl NNS cord-015306-us58wwmp 227 22 , , , cord-015306-us58wwmp 227 23 aged aged JJ cord-015306-us58wwmp 227 24 5 5 CD cord-015306-us58wwmp 227 25 - - SYM cord-015306-us58wwmp 227 26 17 17 CD cord-015306-us58wwmp 227 27 years year NNS cord-015306-us58wwmp 227 28 old old JJ cord-015306-us58wwmp 227 29 , , , cord-015306-us58wwmp 227 30 43 43 CD cord-015306-us58wwmp 227 31 ( ( -LRB- cord-015306-us58wwmp 227 32 38.8 38.8 CD cord-015306-us58wwmp 227 33 % % NN cord-015306-us58wwmp 227 34 ) ) -RRB- cord-015306-us58wwmp 227 35 with with IN cord-015306-us58wwmp 227 36 MNE MNE NNP cord-015306-us58wwmp 227 37 and and CC cord-015306-us58wwmp 227 38 68 68 CD cord-015306-us58wwmp 227 39 ( ( -LRB- cord-015306-us58wwmp 227 40 61.2 61.2 CD cord-015306-us58wwmp 227 41 % % NN cord-015306-us58wwmp 227 42 ) ) -RRB- cord-015306-us58wwmp 227 43 with with IN cord-015306-us58wwmp 227 44 NMNE NMNE NNP cord-015306-us58wwmp 227 45 . . . cord-015306-us58wwmp 228 1 Urine urine NN cord-015306-us58wwmp 228 2 analysis analysis NN cord-015306-us58wwmp 228 3 , , , cord-015306-us58wwmp 228 4 urine urine NN cord-015306-us58wwmp 228 5 culture culture NN cord-015306-us58wwmp 228 6 and and CC cord-015306-us58wwmp 228 7 kidney kidney NN cord-015306-us58wwmp 228 8 bladder bladder NN cord-015306-us58wwmp 228 9 ultra ultra JJ cord-015306-us58wwmp 228 10 sonography sonography NN cord-015306-us58wwmp 228 11 was be VBD cord-015306-us58wwmp 228 12 done do VBN cord-015306-us58wwmp 228 13 for for IN cord-015306-us58wwmp 228 14 all all DT cord-015306-us58wwmp 228 15 .Some .Some . cord-015306-us58wwmp 229 1 patients patient NNS cord-015306-us58wwmp 229 2 underwent undergo VBD cord-015306-us58wwmp 229 3 voiding void VBG cord-015306-us58wwmp 229 4 cystoureterography cystoureterography NN cord-015306-us58wwmp 229 5 ( ( -LRB- cord-015306-us58wwmp 229 6 VCUG VCUG NNP cord-015306-us58wwmp 229 7 ) ) -RRB- cord-015306-us58wwmp 229 8 , , , cord-015306-us58wwmp 229 9 urodynamic urodynamic JJ cord-015306-us58wwmp 229 10 study study NN cord-015306-us58wwmp 229 11 ( ( -LRB- cord-015306-us58wwmp 229 12 UDS UDS NNP cord-015306-us58wwmp 229 13 ) ) -RRB- cord-015306-us58wwmp 229 14 , , , cord-015306-us58wwmp 229 15 or or CC cord-015306-us58wwmp 229 16 both both DT cord-015306-us58wwmp 229 17 . . . cord-015306-us58wwmp 230 1 Results result NNS cord-015306-us58wwmp 230 2 : : : cord-015306-us58wwmp 231 1 Patients patient NNS cord-015306-us58wwmp 231 2 were be VBD cord-015306-us58wwmp 231 3 divided divide VBN cord-015306-us58wwmp 231 4 in in IN cord-015306-us58wwmp 231 5 to to IN cord-015306-us58wwmp 231 6 3 3 CD cord-015306-us58wwmp 231 7 groups group NNS cord-015306-us58wwmp 231 8 : : : cord-015306-us58wwmp 231 9 MNE MNE NNP cord-015306-us58wwmp 231 10 , , , cord-015306-us58wwmp 231 11 NMNE NMNE NNP cord-015306-us58wwmp 231 12 daytime daytime JJ cord-015306-us58wwmp 231 13 incontinence incontinence NN cord-015306-us58wwmp 231 14 and and CC cord-015306-us58wwmp 231 15 NMNE NMNE NNP cord-015306-us58wwmp 231 16 + + CC cord-015306-us58wwmp 231 17 daytime daytime JJ cord-015306-us58wwmp 231 18 incontinence incontinence NN cord-015306-us58wwmp 231 19 . . . cord-015306-us58wwmp 232 1 Constipation constipation NN cord-015306-us58wwmp 232 2 , , , cord-015306-us58wwmp 232 3 encopresis encopresis NN cord-015306-us58wwmp 232 4 and and CC cord-015306-us58wwmp 232 5 urge urge VB cord-015306-us58wwmp 232 6 incontinence incontinence NN cord-015306-us58wwmp 232 7 were be VBD cord-015306-us58wwmp 232 8 significantly significantly RB cord-015306-us58wwmp 232 9 more more RBR cord-015306-us58wwmp 232 10 frequent frequent JJ cord-015306-us58wwmp 232 11 in in IN cord-015306-us58wwmp 232 12 patients patient NNS cord-015306-us58wwmp 232 13 with with IN cord-015306-us58wwmp 232 14 NMNE NMNE NNP cord-015306-us58wwmp 232 15 + + CC cord-015306-us58wwmp 232 16 daytime daytime JJ cord-015306-us58wwmp 232 17 incontinence incontinence NN cord-015306-us58wwmp 232 18 ( ( -LRB- cord-015306-us58wwmp 232 19 P= p= NN cord-015306-us58wwmp 232 20 0.011 0.011 CD cord-015306-us58wwmp 232 21 , , , cord-015306-us58wwmp 232 22 0.003 0.003 CD cord-015306-us58wwmp 232 23 , , , cord-015306-us58wwmp 232 24 0.001 0.001 CD cord-015306-us58wwmp 232 25 respectively respectively RB cord-015306-us58wwmp 232 26 ) ) -RRB- cord-015306-us58wwmp 232 27 . . . cord-015306-us58wwmp 233 1 Bladder bladder NN cord-015306-us58wwmp 233 2 wall wall NN cord-015306-us58wwmp 233 3 thickness thickness NN cord-015306-us58wwmp 233 4 was be VBD cord-015306-us58wwmp 233 5 the the DT cord-015306-us58wwmp 233 6 most most RBS cord-015306-us58wwmp 233 7 common common JJ cord-015306-us58wwmp 233 8 US US NNP cord-015306-us58wwmp 233 9 findings finding NNS cord-015306-us58wwmp 233 10 .. .. . cord-015306-us58wwmp 234 1 One one CD cord-015306-us58wwmp 234 2 patient patient NN cord-015306-us58wwmp 234 3 with with IN cord-015306-us58wwmp 234 4 MNE MNE NNP cord-015306-us58wwmp 234 5 and and CC cord-015306-us58wwmp 234 6 9 9 CD cord-015306-us58wwmp 234 7 with with IN cord-015306-us58wwmp 234 8 NMNE+ NMNE+ NNP cord-015306-us58wwmp 234 9 daytime daytime JJ cord-015306-us58wwmp 234 10 incontinence incontinence NN cord-015306-us58wwmp 234 11 had have VBD cord-015306-us58wwmp 234 12 vesico vesico NN cord-015306-us58wwmp 234 13 -ureteral -ureteral NNP cord-015306-us58wwmp 234 14 reflux(VUR reflux(VUR NNS cord-015306-us58wwmp 234 15 ) ) -RRB- cord-015306-us58wwmp 234 16 ) ) -RRB- cord-015306-us58wwmp 235 1 ( ( -LRB- cord-015306-us58wwmp 235 2 P=0.016).Posterior P=0.016).Posterior NNP cord-015306-us58wwmp 235 3 urethral urethral JJ cord-015306-us58wwmp 235 4 valve valve NN cord-015306-us58wwmp 235 5 was be VBD cord-015306-us58wwmp 235 6 reported report VBN cord-015306-us58wwmp 235 7 in in IN cord-015306-us58wwmp 235 8 one one CD cord-015306-us58wwmp 235 9 patient patient NN cord-015306-us58wwmp 235 10 with with IN cord-015306-us58wwmp 235 11 NMNE NMNE NNP cord-015306-us58wwmp 235 12 . . . cord-015306-us58wwmp 236 1 Evidences evidence NNS cord-015306-us58wwmp 236 2 of of IN cord-015306-us58wwmp 236 3 bladder bladder NN cord-015306-us58wwmp 236 4 dysfunction dysfunction NN cord-015306-us58wwmp 236 5 were be VBD cord-015306-us58wwmp 236 6 noted note VBN cord-015306-us58wwmp 236 7 in in IN cord-015306-us58wwmp 236 8 about about IN cord-015306-us58wwmp 236 9 half half NN cord-015306-us58wwmp 236 10 of of IN cord-015306-us58wwmp 236 11 the the DT cord-015306-us58wwmp 236 12 patients patient NNS cord-015306-us58wwmp 236 13 who who WP cord-015306-us58wwmp 236 14 underwent undergo VBD cord-015306-us58wwmp 236 15 UDS UDS NNP cord-015306-us58wwmp 236 16 , , , cord-015306-us58wwmp 236 17 with with IN cord-015306-us58wwmp 236 18 higher high JJR cord-015306-us58wwmp 236 19 prevalence prevalence NN cord-015306-us58wwmp 236 20 in in IN cord-015306-us58wwmp 236 21 cases case NNS cord-015306-us58wwmp 236 22 with with IN cord-015306-us58wwmp 236 23 NMNE NMNE NNP cord-015306-us58wwmp 236 24 + + CC cord-015306-us58wwmp 236 25 daytime daytime JJ cord-015306-us58wwmp 236 26 urinary urinary JJ cord-015306-us58wwmp 236 27 incontinence(P=0.297 incontinence(p=0.297 NN cord-015306-us58wwmp 236 28 ) ) -RRB- cord-015306-us58wwmp 236 29 . . . cord-015306-us58wwmp 237 1 Bowel bowel NN cord-015306-us58wwmp 237 2 symptoms symptom NNS cord-015306-us58wwmp 237 3 and and CC cord-015306-us58wwmp 237 4 VUR VUR NNP cord-015306-us58wwmp 237 5 were be VBD cord-015306-us58wwmp 237 6 significantly significantly RB cord-015306-us58wwmp 237 7 more more RBR cord-015306-us58wwmp 237 8 prevalent prevalent JJ cord-015306-us58wwmp 237 9 in in IN cord-015306-us58wwmp 237 10 cases case NNS cord-015306-us58wwmp 237 11 with with IN cord-015306-us58wwmp 237 12 NMNE NMNE NNP cord-015306-us58wwmp 237 13 + + CC cord-015306-us58wwmp 237 14 daytime daytime JJ cord-015306-us58wwmp 237 15 incontinence incontinence NN cord-015306-us58wwmp 237 16 . . . cord-015306-us58wwmp 238 1 Conclusion conclusion NN cord-015306-us58wwmp 238 2 : : : cord-015306-us58wwmp 238 3 We -PRON- PRP cord-015306-us58wwmp 238 4 recommend recommend VBP cord-015306-us58wwmp 238 5 doing do VBG cord-015306-us58wwmp 238 6 VCUG VCUG NNP cord-015306-us58wwmp 238 7 in in IN cord-015306-us58wwmp 238 8 enuretic enuretic JJ cord-015306-us58wwmp 238 9 children child NNS cord-015306-us58wwmp 238 10 who who WP cord-015306-us58wwmp 238 11 have have VBP cord-015306-us58wwmp 238 12 daytime daytime JJ cord-015306-us58wwmp 238 13 incontinence incontinence NN cord-015306-us58wwmp 238 14 . . . cord-015306-us58wwmp 239 1 In in IN cord-015306-us58wwmp 239 2 addition addition NN cord-015306-us58wwmp 239 3 our -PRON- PRP$ cord-015306-us58wwmp 239 4 study study NN cord-015306-us58wwmp 239 5 revealed reveal VBD cord-015306-us58wwmp 239 6 that that IN cord-015306-us58wwmp 239 7 symptoms symptom NNS cord-015306-us58wwmp 239 8 suggestive suggestive JJ cord-015306-us58wwmp 239 9 of of IN cord-015306-us58wwmp 239 10 over over IN cord-015306-us58wwmp 239 11 active active JJ cord-015306-us58wwmp 239 12 bladder bladder NN cord-015306-us58wwmp 239 13 are be VBP cord-015306-us58wwmp 239 14 not not RB cord-015306-us58wwmp 239 15 good good JJ cord-015306-us58wwmp 239 16 indicators indicator NNS cord-015306-us58wwmp 239 17 for for IN cord-015306-us58wwmp 239 18 bladder bladder NN cord-015306-us58wwmp 239 19 dysfunction dysfunction NN cord-015306-us58wwmp 239 20 . . . cord-015306-us58wwmp 240 1 Abstract abstract JJ cord-015306-us58wwmp 240 2 # # NN cord-015306-us58wwmp 240 3 P p NN cord-015306-us58wwmp 240 4 - - HYPH cord-015306-us58wwmp 240 5 SAT049 SAT049 NNP cord-015306-us58wwmp 240 6 Correspondence Correspondence NNP cord-015306-us58wwmp 240 7 between between IN cord-015306-us58wwmp 240 8 urinary urinary JJ cord-015306-us58wwmp 240 9 calcium calcium NN cord-015306-us58wwmp 240 10 , , , cord-015306-us58wwmp 241 1 Ca ca NN cord-015306-us58wwmp 241 2 2 2 CD cord-015306-us58wwmp 241 3 + + CC cord-015306-us58wwmp 241 4 concentration concentration NN cord-015306-us58wwmp 241 5 and and CC cord-015306-us58wwmp 241 6 osmolality osmolality NN cord-015306-us58wwmp 241 7 in in IN cord-015306-us58wwmp 241 8 enuretic enuretic JJ cord-015306-us58wwmp 241 9 children child NNS cord-015306-us58wwmp 241 10 Agata Agata NNP cord-015306-us58wwmp 241 11 Korzeniecka Korzeniecka NNP cord-015306-us58wwmp 241 12 - - HYPH cord-015306-us58wwmp 241 13 Kozerska Kozerska NNP cord-015306-us58wwmp 241 14 , , , cord-015306-us58wwmp 241 15 Tadeusz Tadeusz NNP cord-015306-us58wwmp 241 16 Porowski Porowski NNP cord-015306-us58wwmp 241 17 Department Department NNP cord-015306-us58wwmp 241 18 of of IN cord-015306-us58wwmp 241 19 Paediatrics Paediatrics NNP cord-015306-us58wwmp 241 20 and and CC cord-015306-us58wwmp 241 21 Nephrology Nephrology NNP cord-015306-us58wwmp 241 22 , , , cord-015306-us58wwmp 241 23 Medical Medical NNP cord-015306-us58wwmp 241 24 University University NNP cord-015306-us58wwmp 241 25 of of IN cord-015306-us58wwmp 241 26 Bialystok Bialystok NNP cord-015306-us58wwmp 241 27 , , , cord-015306-us58wwmp 241 28 Bialystok Bialystok NNP cord-015306-us58wwmp 241 29 , , , cord-015306-us58wwmp 242 1 Poland Poland NNP cord-015306-us58wwmp 242 2 Objective Objective NNP cord-015306-us58wwmp 242 3 : : : cord-015306-us58wwmp 243 1 Among among IN cord-015306-us58wwmp 243 2 many many JJ cord-015306-us58wwmp 243 3 factors factor NNS cord-015306-us58wwmp 243 4 predisposing predispose VBG cord-015306-us58wwmp 243 5 to to IN cord-015306-us58wwmp 243 6 enuresis enuresis NN cord-015306-us58wwmp 243 7 hypercalciuria hypercalciuria NNP cord-015306-us58wwmp 243 8 may may MD cord-015306-us58wwmp 243 9 play play VB cord-015306-us58wwmp 243 10 an an DT cord-015306-us58wwmp 243 11 important important JJ cord-015306-us58wwmp 243 12 role role NN cord-015306-us58wwmp 243 13 . . . cord-015306-us58wwmp 244 1 Hypercalciuria Hypercalciuria NNP cord-015306-us58wwmp 244 2 is be VBZ cord-015306-us58wwmp 244 3 be be VB cord-015306-us58wwmp 244 4 observed observe VBN cord-015306-us58wwmp 244 5 in in IN cord-015306-us58wwmp 244 6 patients patient NNS cord-015306-us58wwmp 244 7 both both CC cord-015306-us58wwmp 244 8 in in IN cord-015306-us58wwmp 244 9 patients patient NNS cord-015306-us58wwmp 244 10 with with IN cord-015306-us58wwmp 244 11 nocturnal nocturnal JJ cord-015306-us58wwmp 244 12 polyuria polyuria NN cord-015306-us58wwmp 244 13 and and CC cord-015306-us58wwmp 244 14 without without IN cord-015306-us58wwmp 244 15 . . . cord-015306-us58wwmp 245 1 Hence hence RB cord-015306-us58wwmp 245 2 , , , cord-015306-us58wwmp 245 3 we -PRON- PRP cord-015306-us58wwmp 245 4 decided decide VBD cord-015306-us58wwmp 245 5 to to TO cord-015306-us58wwmp 245 6 assess assess VB cord-015306-us58wwmp 245 7 urine urine NN cord-015306-us58wwmp 245 8 concentration concentration NN cord-015306-us58wwmp 245 9 of of IN cord-015306-us58wwmp 245 10 calcium calcium NN cord-015306-us58wwmp 245 11 ( ( -LRB- cord-015306-us58wwmp 245 12 mmol mmol NNP cord-015306-us58wwmp 245 13 / / SYM cord-015306-us58wwmp 245 14 L L NNP cord-015306-us58wwmp 245 15 ) ) -RRB- cord-015306-us58wwmp 245 16 and and CC cord-015306-us58wwmp 246 1 Ca ca NN cord-015306-us58wwmp 246 2 2 2 CD cord-015306-us58wwmp 246 3 + + CD cord-015306-us58wwmp 246 4 ( ( -LRB- cord-015306-us58wwmp 246 5 mmol mmol NNP cord-015306-us58wwmp 246 6 / / SYM cord-015306-us58wwmp 246 7 L L NNP cord-015306-us58wwmp 246 8 ) ) -RRB- cord-015306-us58wwmp 246 9 in in IN cord-015306-us58wwmp 246 10 patients patient NNS cord-015306-us58wwmp 246 11 with with IN cord-015306-us58wwmp 246 12 monosymptomatic monosymptomatic JJ cord-015306-us58wwmp 246 13 enuresis enuresis NN cord-015306-us58wwmp 246 14 and and CC cord-015306-us58wwmp 246 15 answer answer VB cord-015306-us58wwmp 246 16 the the DT cord-015306-us58wwmp 246 17 question question NN cord-015306-us58wwmp 246 18 if if IN cord-015306-us58wwmp 246 19 patients patient NNS cord-015306-us58wwmp 246 20 with with IN cord-015306-us58wwmp 246 21 enuresis enuresis NN cord-015306-us58wwmp 246 22 present present JJ cord-015306-us58wwmp 246 23 calcium calcium NN cord-015306-us58wwmp 246 24 balance balance NN cord-015306-us58wwmp 246 25 disturbances disturbance NNS cord-015306-us58wwmp 246 26 Methods method NNS cord-015306-us58wwmp 246 27 : : : cord-015306-us58wwmp 246 28 The the DT cord-015306-us58wwmp 246 29 study study NN cord-015306-us58wwmp 246 30 was be VBD cord-015306-us58wwmp 246 31 conducted conduct VBN cord-015306-us58wwmp 246 32 on on IN cord-015306-us58wwmp 246 33 204 204 CD cord-015306-us58wwmp 246 34 children child NNS cord-015306-us58wwmp 246 35 ( ( -LRB- cord-015306-us58wwmp 246 36 83 83 CD cord-015306-us58wwmp 246 37 enuretic enuretic NN cord-015306-us58wwmp 246 38 aged age VBN cord-015306-us58wwmp 246 39 median median JJ cord-015306-us58wwmp 246 40 9.66 9.66 CD cord-015306-us58wwmp 246 41 ( ( -LRB- cord-015306-us58wwmp 246 42 4.16 4.16 CD cord-015306-us58wwmp 246 43 - - SYM cord-015306-us58wwmp 246 44 16.98 16.98 CD cord-015306-us58wwmp 246 45 ) ) -RRB- cord-015306-us58wwmp 246 46 yrs yr NNS cord-015306-us58wwmp 246 47 diagnosed diagnose VBN cord-015306-us58wwmp 246 48 with with IN cord-015306-us58wwmp 246 49 monosymptomatic monosymptomatic JJ cord-015306-us58wwmp 246 50 enuresis enuresis NN cord-015306-us58wwmp 246 51 after after IN cord-015306-us58wwmp 246 52 6 6 CD cord-015306-us58wwmp 246 53 months month NNS cord-015306-us58wwmp 246 54 of of IN cord-015306-us58wwmp 246 55 unsuccessful unsuccessful JJ cord-015306-us58wwmp 246 56 non non JJ cord-015306-us58wwmp 246 57 farmacological farmacological JJ cord-015306-us58wwmp 246 58 treatment treatment NN cord-015306-us58wwmp 246 59 and and CC cord-015306-us58wwmp 246 60 121 121 CD cord-015306-us58wwmp 246 61 healthy healthy JJ cord-015306-us58wwmp 246 62 children child NNS cord-015306-us58wwmp 246 63 aged age VBN cord-015306-us58wwmp 246 64 median median NN cord-015306-us58wwmp 246 65 9.99 9.99 CD cord-015306-us58wwmp 246 66 ( ( -LRB- cord-015306-us58wwmp 246 67 4.15 4.15 CD cord-015306-us58wwmp 246 68 - - SYM cord-015306-us58wwmp 246 69 16.86 16.86 CD cord-015306-us58wwmp 246 70 ) ) -RRB- cord-015306-us58wwmp 246 71 yrs yr NNS cord-015306-us58wwmp 246 72 . . . cord-015306-us58wwmp 247 1 We -PRON- PRP cord-015306-us58wwmp 247 2 collected collect VBD cord-015306-us58wwmp 247 3 24-h 24-h JJ cord-015306-us58wwmp 247 4 urine urine NN cord-015306-us58wwmp 247 5 samples sample NNS cord-015306-us58wwmp 247 6 from from IN cord-015306-us58wwmp 247 7 all all DT cord-015306-us58wwmp 247 8 children child NNS cord-015306-us58wwmp 247 9 enrolled enrol VBN cord-015306-us58wwmp 247 10 to to IN cord-015306-us58wwmp 247 11 the the DT cord-015306-us58wwmp 247 12 study study NN cord-015306-us58wwmp 247 13 . . . cord-015306-us58wwmp 248 1 Calcium calcium NN cord-015306-us58wwmp 248 2 concentration concentration NN cord-015306-us58wwmp 248 3 , , , cord-015306-us58wwmp 248 4 Ca ca NN cord-015306-us58wwmp 248 5 2 2 CD cord-015306-us58wwmp 249 1 + + CC cord-015306-us58wwmp 249 2 , , , cord-015306-us58wwmp 249 3 pH pH NNP cord-015306-us58wwmp 249 4 , , , cord-015306-us58wwmp 249 5 osmolality osmolality NN cord-015306-us58wwmp 249 6 of of IN cord-015306-us58wwmp 249 7 urine urine NN cord-015306-us58wwmp 249 8 and and CC cord-015306-us58wwmp 249 9 additionally additionally RB cord-015306-us58wwmp 249 10 daily daily JJ cord-015306-us58wwmp 249 11 sodium sodium NN cord-015306-us58wwmp 249 12 excretion excretion NN cord-015306-us58wwmp 249 13 were be VBD cord-015306-us58wwmp 249 14 estimated estimate VBN cord-015306-us58wwmp 249 15 and and CC cord-015306-us58wwmp 249 16 compared compare VBN cord-015306-us58wwmp 249 17 between between IN cord-015306-us58wwmp 249 18 two two CD cord-015306-us58wwmp 249 19 groups group NNS cord-015306-us58wwmp 249 20 . . . cord-015306-us58wwmp 250 1 Statistical statistical JJ cord-015306-us58wwmp 250 2 analysis analysis NN cord-015306-us58wwmp 250 3 were be VBD cord-015306-us58wwmp 250 4 performed perform VBN cord-015306-us58wwmp 250 5 using use VBG cord-015306-us58wwmp 250 6 Statistica Statistica NNP cord-015306-us58wwmp 250 7 ver ver NN cord-015306-us58wwmp 250 8 . . . cord-015306-us58wwmp 251 1 10.0 10.0 CD cord-015306-us58wwmp 252 1 ( ( -LRB- cord-015306-us58wwmp 252 2 StatSoft StatSoft NNP cord-015306-us58wwmp 252 3 , , , cord-015306-us58wwmp 252 4 Tulsa Tulsa NNP cord-015306-us58wwmp 252 5 , , , cord-015306-us58wwmp 252 6 Ok ok UH cord-015306-us58wwmp 252 7 ) ) -RRB- cord-015306-us58wwmp 252 8 . . . cord-015306-us58wwmp 253 1 The the DT cord-015306-us58wwmp 253 2 Mann Mann NNP cord-015306-us58wwmp 253 3 - - HYPH cord-015306-us58wwmp 253 4 Whitney Whitney NNP cord-015306-us58wwmp 253 5 U U NNP cord-015306-us58wwmp 253 6 test test NN cord-015306-us58wwmp 253 7 was be VBD cord-015306-us58wwmp 253 8 used use VBN cord-015306-us58wwmp 253 9 for for IN cord-015306-us58wwmp 253 10 comparisons comparison NNS cord-015306-us58wwmp 253 11 between between IN cord-015306-us58wwmp 253 12 two two CD cord-015306-us58wwmp 253 13 independent independent JJ cord-015306-us58wwmp 253 14 parameters parameter NNS cord-015306-us58wwmp 253 15 . . . cord-015306-us58wwmp 254 1 Correlations correlation NNS cord-015306-us58wwmp 254 2 were be VBD cord-015306-us58wwmp 254 3 made make VBN cord-015306-us58wwmp 254 4 with with IN cord-015306-us58wwmp 254 5 Spearman Spearman NNP cord-015306-us58wwmp 254 6 test test NN cord-015306-us58wwmp 254 7 . . . cord-015306-us58wwmp 255 1 A a DT cord-015306-us58wwmp 255 2 p p NN cord-015306-us58wwmp 255 3 value value NN cord-015306-us58wwmp 255 4 of of IN cord-015306-us58wwmp 255 5 < < NNP cord-015306-us58wwmp 255 6 0.05 0.05 CD cord-015306-us58wwmp 255 7 was be VBD cord-015306-us58wwmp 255 8 considered consider VBN cord-015306-us58wwmp 255 9 to to TO cord-015306-us58wwmp 255 10 be be VB cord-015306-us58wwmp 255 11 statistically statistically RB cord-015306-us58wwmp 255 12 significant significant JJ cord-015306-us58wwmp 255 13 . . . cord-015306-us58wwmp 256 1 Results result NNS cord-015306-us58wwmp 256 2 : : : cord-015306-us58wwmp 257 1 There there EX cord-015306-us58wwmp 257 2 were be VBD cord-015306-us58wwmp 257 3 no no DT cord-015306-us58wwmp 257 4 differences difference NNS cord-015306-us58wwmp 257 5 in in IN cord-015306-us58wwmp 257 6 age age NN cord-015306-us58wwmp 257 7 , , , cord-015306-us58wwmp 257 8 gender gender NN cord-015306-us58wwmp 257 9 and and CC cord-015306-us58wwmp 257 10 parameters parameter NNS cord-015306-us58wwmp 257 11 of of IN cord-015306-us58wwmp 257 12 physical physical JJ cord-015306-us58wwmp 257 13 development development NN cord-015306-us58wwmp 257 14 between between IN cord-015306-us58wwmp 257 15 both both CC cord-015306-us58wwmp 257 16 studied study VBN cord-015306-us58wwmp 257 17 groups group NNS cord-015306-us58wwmp 257 18 and and CC cord-015306-us58wwmp 257 19 between between IN cord-015306-us58wwmp 257 20 girls girl NNS cord-015306-us58wwmp 257 21 and and CC cord-015306-us58wwmp 257 22 boys boy NNS cord-015306-us58wwmp 257 23 among among IN cord-015306-us58wwmp 257 24 groups group NNS cord-015306-us58wwmp 257 25 . . . cord-015306-us58wwmp 258 1 Urinary urinary JJ cord-015306-us58wwmp 258 2 calcium calcium NN cord-015306-us58wwmp 258 3 concentration concentration NN cord-015306-us58wwmp 258 4 in in IN cord-015306-us58wwmp 258 5 enuretic enuretic JJ cord-015306-us58wwmp 258 6 children child NNS cord-015306-us58wwmp 258 7 did do VBD cord-015306-us58wwmp 258 8 not not RB cord-015306-us58wwmp 258 9 differ differ VB cord-015306-us58wwmp 258 10 compared compare VBN cord-015306-us58wwmp 258 11 to to IN cord-015306-us58wwmp 258 12 reference reference NN cord-015306-us58wwmp 258 13 group group NN cord-015306-us58wwmp 258 14 ( ( -LRB- cord-015306-us58wwmp 258 15 p=0.993 p=0.993 NNP cord-015306-us58wwmp 258 16 ) ) -RRB- cord-015306-us58wwmp 258 17 . . . cord-015306-us58wwmp 259 1 We -PRON- PRP cord-015306-us58wwmp 259 2 found find VBD cord-015306-us58wwmp 259 3 statistically statistically RB cord-015306-us58wwmp 259 4 significant significant JJ cord-015306-us58wwmp 259 5 differences difference NNS cord-015306-us58wwmp 259 6 in in IN cord-015306-us58wwmp 259 7 urinary urinary JJ cord-015306-us58wwmp 259 8 Ca Ca NNP cord-015306-us58wwmp 259 9 2 2 CD cord-015306-us58wwmp 259 10 + + CC cord-015306-us58wwmp 259 11 concentration concentration NN cord-015306-us58wwmp 259 12 ( ( -LRB- cord-015306-us58wwmp 259 13 p= p= NNP cord-015306-us58wwmp 259 14 0.001 0.001 CD cord-015306-us58wwmp 259 15 ) ) -RRB- cord-015306-us58wwmp 259 16 and and CC cord-015306-us58wwmp 259 17 osmolality osmolality NN cord-015306-us58wwmp 259 18 ( ( -LRB- cord-015306-us58wwmp 259 19 p=0.02 p=0.02 NN cord-015306-us58wwmp 259 20 ) ) -RRB- cord-015306-us58wwmp 259 21 between between IN cord-015306-us58wwmp 259 22 both both DT cord-015306-us58wwmp 259 23 studied study VBN cord-015306-us58wwmp 259 24 group group NN cord-015306-us58wwmp 259 25 . . . cord-015306-us58wwmp 260 1 Ca Ca NNP cord-015306-us58wwmp 260 2 2 2 CD cord-015306-us58wwmp 260 3 + + CC cord-015306-us58wwmp 260 4 in in IN cord-015306-us58wwmp 260 5 urine urine NN cord-015306-us58wwmp 260 6 correlated correlate VBN cord-015306-us58wwmp 260 7 negatively negatively RB cord-015306-us58wwmp 260 8 with with IN cord-015306-us58wwmp 260 9 age age NN cord-015306-us58wwmp 260 10 and and CC cord-015306-us58wwmp 260 11 parameters parameter NNS cord-015306-us58wwmp 260 12 of of IN cord-015306-us58wwmp 260 13 physical physical JJ cord-015306-us58wwmp 260 14 Physical physical JJ cord-015306-us58wwmp 260 15 development development NN cord-015306-us58wwmp 260 16 only only RB cord-015306-us58wwmp 260 17 in in IN cord-015306-us58wwmp 260 18 enuretic enuretic JJ cord-015306-us58wwmp 260 19 patients patient NNS cord-015306-us58wwmp 260 20 . . . cord-015306-us58wwmp 261 1 Additionally additionally RB cord-015306-us58wwmp 261 2 , , , cord-015306-us58wwmp 261 3 positive positive JJ cord-015306-us58wwmp 261 4 correlation correlation NN cord-015306-us58wwmp 261 5 was be VBD cord-015306-us58wwmp 261 6 found find VBN cord-015306-us58wwmp 261 7 between between IN cord-015306-us58wwmp 261 8 Ca Ca NNP cord-015306-us58wwmp 261 9 2 2 CD cord-015306-us58wwmp 261 10 + + SYM cord-015306-us58wwmp 261 11 and and CC cord-015306-us58wwmp 261 12 calcium calcium NN cord-015306-us58wwmp 261 13 concentration concentration NN cord-015306-us58wwmp 261 14 ( ( -LRB- cord-015306-us58wwmp 261 15 R r NN cord-015306-us58wwmp 261 16 = = SYM cord-015306-us58wwmp 261 17 0.7923 0.7923 CD cord-015306-us58wwmp 261 18 ; ; : cord-015306-us58wwmp 261 19 p<0.005 p<0.005 CD cord-015306-us58wwmp 261 20 ) ) -RRB- cord-015306-us58wwmp 262 1 and and CC cord-015306-us58wwmp 262 2 between between IN cord-015306-us58wwmp 262 3 Ca Ca NNP cord-015306-us58wwmp 262 4 2 2 CD cord-015306-us58wwmp 262 5 + + SYM cord-015306-us58wwmp 262 6 and and CC cord-015306-us58wwmp 262 7 osmolality osmolality NN cord-015306-us58wwmp 263 1 ( ( -LRB- cord-015306-us58wwmp 263 2 R=0.2795 R=0.2795 NNP cord-015306-us58wwmp 263 3 ; ; : cord-015306-us58wwmp 263 4 p<0.05 p<0.05 CD cord-015306-us58wwmp 263 5 ) ) -RRB- cord-015306-us58wwmp 264 1 in in IN cord-015306-us58wwmp 264 2 urine urine NN cord-015306-us58wwmp 264 3 of of IN cord-015306-us58wwmp 264 4 enuretic enuretic JJ cord-015306-us58wwmp 264 5 children child NNS cord-015306-us58wwmp 264 6 . . . cord-015306-us58wwmp 265 1 Positive positive JJ cord-015306-us58wwmp 265 2 correlation correlation NN cord-015306-us58wwmp 265 3 was be VBD cord-015306-us58wwmp 265 4 also also RB cord-015306-us58wwmp 265 5 observed observe VBN cord-015306-us58wwmp 265 6 between between IN cord-015306-us58wwmp 265 7 Ca Ca NNP cord-015306-us58wwmp 265 8 2 2 CD cord-015306-us58wwmp 265 9 + + SYM cord-015306-us58wwmp 265 10 and and CC cord-015306-us58wwmp 265 11 daily daily JJ cord-015306-us58wwmp 265 12 natrium natrium NNP cord-015306-us58wwmp 265 13 excretion excretion NN cord-015306-us58wwmp 265 14 ( ( -LRB- cord-015306-us58wwmp 265 15 R=0.318 r=0.318 NN cord-015306-us58wwmp 265 16 ; ; : cord-015306-us58wwmp 265 17 p<0.05 p<0.05 CD cord-015306-us58wwmp 265 18 ) ) -RRB- cord-015306-us58wwmp 265 19 in in IN cord-015306-us58wwmp 265 20 enuretic enuretic JJ cord-015306-us58wwmp 265 21 children child NNS cord-015306-us58wwmp 265 22 . . . cord-015306-us58wwmp 266 1 Conclusion conclusion NN cord-015306-us58wwmp 266 2 : : : cord-015306-us58wwmp 267 1 Disturbed disturbed JJ cord-015306-us58wwmp 267 2 calcium calcium NN cord-015306-us58wwmp 267 3 balance balance NN cord-015306-us58wwmp 267 4 may may MD cord-015306-us58wwmp 267 5 play play VB cord-015306-us58wwmp 267 6 an an DT cord-015306-us58wwmp 267 7 important important JJ cord-015306-us58wwmp 267 8 role role NN cord-015306-us58wwmp 267 9 in in IN cord-015306-us58wwmp 267 10 pathogenesis pathogenesis NN cord-015306-us58wwmp 267 11 of of IN cord-015306-us58wwmp 267 12 monosymtomatic monosymtomatic JJ cord-015306-us58wwmp 267 13 enuresis enuresis NN cord-015306-us58wwmp 267 14 . . . cord-015306-us58wwmp 268 1 It -PRON- PRP cord-015306-us58wwmp 268 2 's be VBZ cord-015306-us58wwmp 268 3 a a DT cord-015306-us58wwmp 268 4 need need NN cord-015306-us58wwmp 268 5 to to TO cord-015306-us58wwmp 268 6 assess assess VB cord-015306-us58wwmp 268 7 calcium calcium NN cord-015306-us58wwmp 268 8 and and CC cord-015306-us58wwmp 268 9 natrium natrium NN cord-015306-us58wwmp 268 10 excretion excretion NN cord-015306-us58wwmp 268 11 in in IN cord-015306-us58wwmp 268 12 enuretic enuretic JJ cord-015306-us58wwmp 268 13 children child NNS cord-015306-us58wwmp 268 14 . . . cord-015306-us58wwmp 269 1 Abstract abstract JJ cord-015306-us58wwmp 269 2 # # NN cord-015306-us58wwmp 269 3 P p NN cord-015306-us58wwmp 269 4 - - HYPH cord-015306-us58wwmp 269 5 SAT050 SAT050 NNP cord-015306-us58wwmp 269 6 Usefulness Usefulness NNP cord-015306-us58wwmp 269 7 of of IN cord-015306-us58wwmp 269 8 the the DT cord-015306-us58wwmp 269 9 application application NN cord-015306-us58wwmp 269 10 of of IN cord-015306-us58wwmp 269 11 questionnaires questionnaire NNS cord-015306-us58wwmp 269 12 to to TO cord-015306-us58wwmp 269 13 detect detect VB cord-015306-us58wwmp 269 14 attention attention NN cord-015306-us58wwmp 269 15 deficit deficit NN cord-015306-us58wwmp 269 16 hyperactivity hyperactivity NN cord-015306-us58wwmp 269 17 disorder disorder NN cord-015306-us58wwmp 269 18 ( ( -LRB- cord-015306-us58wwmp 269 19 ADHD ADHD NNP cord-015306-us58wwmp 269 20 ) ) -RRB- cord-015306-us58wwmp 269 21 and and CC cord-015306-us58wwmp 269 22 other other JJ cord-015306-us58wwmp 269 23 psychiatric psychiatric JJ cord-015306-us58wwmp 269 24 disorders disorder NNS cord-015306-us58wwmp 269 25 in in IN cord-015306-us58wwmp 269 26 children child NNS cord-015306-us58wwmp 269 27 with with IN cord-015306-us58wwmp 269 28 functional functional JJ cord-015306-us58wwmp 269 29 voiding voiding NN cord-015306-us58wwmp 269 30 disorders disorder NNS cord-015306-us58wwmp 269 31 Sandra Sandra NNP cord-015306-us58wwmp 269 32 Gautreaux Gautreaux NNP cord-015306-us58wwmp 269 33 Pediatric Pediatric NNP cord-015306-us58wwmp 269 34 Nephrology Nephrology NNP cord-015306-us58wwmp 269 35 , , , cord-015306-us58wwmp 269 36 Complejo Complejo NNP cord-015306-us58wwmp 269 37 Asistencial Asistencial NNP cord-015306-us58wwmp 269 38 Universitario Universitario NNP cord-015306-us58wwmp 269 39 de de NNP cord-015306-us58wwmp 269 40 Leon Leon NNP cord-015306-us58wwmp 270 1 , , , cord-015306-us58wwmp 270 2 Spain Spain NNP cord-015306-us58wwmp 270 3 Objective Objective NNP cord-015306-us58wwmp 270 4 : : : cord-015306-us58wwmp 271 1 Although although IN cord-015306-us58wwmp 271 2 the the DT cord-015306-us58wwmp 271 3 relationship relationship NN cord-015306-us58wwmp 271 4 between between IN cord-015306-us58wwmp 271 5 functional functional JJ cord-015306-us58wwmp 271 6 voiding voiding NN cord-015306-us58wwmp 271 7 disorders disorder NNS cord-015306-us58wwmp 271 8 ( ( -LRB- cord-015306-us58wwmp 271 9 FVD FVD NNP cord-015306-us58wwmp 271 10 ) ) -RRB- cord-015306-us58wwmp 271 11 and and CC cord-015306-us58wwmp 271 12 the the DT cord-015306-us58wwmp 271 13 presence presence NN cord-015306-us58wwmp 271 14 of of IN cord-015306-us58wwmp 271 15 a a DT cord-015306-us58wwmp 271 16 psychological psychological JJ cord-015306-us58wwmp 271 17 problem problem NN cord-015306-us58wwmp 271 18 remains remain VBZ cord-015306-us58wwmp 271 19 controversial controversial JJ cord-015306-us58wwmp 271 20 , , , cord-015306-us58wwmp 271 21 the the DT cord-015306-us58wwmp 271 22 greater great JJR cord-015306-us58wwmp 271 23 frequency frequency NN cord-015306-us58wwmp 271 24 of of IN cord-015306-us58wwmp 271 25 ADHD ADHD NNP cord-015306-us58wwmp 271 26 among among IN cord-015306-us58wwmp 271 27 children child NNS cord-015306-us58wwmp 271 28 with with IN cord-015306-us58wwmp 271 29 this this DT cord-015306-us58wwmp 271 30 condition condition NN cord-015306-us58wwmp 271 31 is be VBZ cord-015306-us58wwmp 271 32 well well RB cord-015306-us58wwmp 271 33 known known JJ cord-015306-us58wwmp 271 34 . . . cord-015306-us58wwmp 272 1 The the DT cord-015306-us58wwmp 272 2 purpose purpose NN cord-015306-us58wwmp 272 3 of of IN cord-015306-us58wwmp 272 4 this this DT cord-015306-us58wwmp 272 5 study study NN cord-015306-us58wwmp 272 6 was be VBD cord-015306-us58wwmp 272 7 to to TO cord-015306-us58wwmp 272 8 determine determine VB cord-015306-us58wwmp 272 9 the the DT cord-015306-us58wwmp 272 10 diagnostic diagnostic JJ cord-015306-us58wwmp 272 11 performance performance NN cord-015306-us58wwmp 272 12 of of IN cord-015306-us58wwmp 272 13 the the DT cord-015306-us58wwmp 272 14 application application NN cord-015306-us58wwmp 272 15 of of IN cord-015306-us58wwmp 272 16 questionnaires questionnaire NNS cord-015306-us58wwmp 272 17 to to TO cord-015306-us58wwmp 272 18 detect detect VB cord-015306-us58wwmp 272 19 ADHD ADHD NNP cord-015306-us58wwmp 272 20 and and CC cord-015306-us58wwmp 272 21 other other JJ cord-015306-us58wwmp 272 22 psychiatric psychiatric JJ cord-015306-us58wwmp 272 23 disorders disorder NNS cord-015306-us58wwmp 272 24 in in IN cord-015306-us58wwmp 272 25 children child NNS cord-015306-us58wwmp 272 26 with with IN cord-015306-us58wwmp 272 27 functional functional JJ cord-015306-us58wwmp 272 28 voiding voiding NN cord-015306-us58wwmp 272 29 disorders disorder NNS cord-015306-us58wwmp 272 30 in in IN cord-015306-us58wwmp 272 31 general general JJ cord-015306-us58wwmp 272 32 pediatrics pediatric NNS cord-015306-us58wwmp 272 33 consultations consultation NNS cord-015306-us58wwmp 272 34 Methods Methods NNPS cord-015306-us58wwmp 272 35 : : : cord-015306-us58wwmp 272 36 The the DT cord-015306-us58wwmp 272 37 study study NN cord-015306-us58wwmp 272 38 was be VBD cord-015306-us58wwmp 272 39 conducted conduct VBN cord-015306-us58wwmp 272 40 on on IN cord-015306-us58wwmp 272 41 32 32 CD cord-015306-us58wwmp 272 42 children child NNS cord-015306-us58wwmp 272 43 between between IN cord-015306-us58wwmp 272 44 6 6 CD cord-015306-us58wwmp 272 45 and and CC cord-015306-us58wwmp 272 46 13 13 CD cord-015306-us58wwmp 272 47 years year NNS cord-015306-us58wwmp 272 48 of of IN cord-015306-us58wwmp 272 49 age age NN cord-015306-us58wwmp 272 50 ( ( -LRB- cord-015306-us58wwmp 272 51 20 20 CD cord-015306-us58wwmp 272 52 males male NNS cord-015306-us58wwmp 272 53 ) ) -RRB- cord-015306-us58wwmp 272 54 diagnosed diagnose VBN cord-015306-us58wwmp 272 55 with with IN cord-015306-us58wwmp 272 56 FVD FVD NNP cord-015306-us58wwmp 272 57 ( ( -LRB- cord-015306-us58wwmp 272 58 patient patient JJ cord-015306-us58wwmp 272 59 group group NN cord-015306-us58wwmp 272 60 ) ) -RRB- cord-015306-us58wwmp 272 61 and and CC cord-015306-us58wwmp 272 62 32 32 CD cord-015306-us58wwmp 272 63 children child NNS cord-015306-us58wwmp 272 64 of of IN cord-015306-us58wwmp 272 65 the the DT cord-015306-us58wwmp 272 66 same same JJ cord-015306-us58wwmp 272 67 age age NN cord-015306-us58wwmp 272 68 ( ( -LRB- cord-015306-us58wwmp 272 69 21 21 CD cord-015306-us58wwmp 272 70 males male NNS cord-015306-us58wwmp 272 71 ) ) -RRB- cord-015306-us58wwmp 272 72 who who WP cord-015306-us58wwmp 272 73 had have VBD cord-015306-us58wwmp 272 74 no no DT cord-015306-us58wwmp 272 75 urinary urinary JJ cord-015306-us58wwmp 272 76 symptoms symptom NNS cord-015306-us58wwmp 272 77 ( ( -LRB- cord-015306-us58wwmp 272 78 control control NNP cord-015306-us58wwmp 272 79 group group NN cord-015306-us58wwmp 272 80 ) ) -RRB- cord-015306-us58wwmp 272 81 . . . cord-015306-us58wwmp 273 1 The the DT cord-015306-us58wwmp 273 2 parents parent NNS cord-015306-us58wwmp 273 3 of of IN cord-015306-us58wwmp 273 4 these these DT cord-015306-us58wwmp 273 5 children child NNS cord-015306-us58wwmp 273 6 responded respond VBD cord-015306-us58wwmp 273 7 to to IN cord-015306-us58wwmp 273 8 the the DT cord-015306-us58wwmp 273 9 questions question NNS cord-015306-us58wwmp 273 10 in in IN cord-015306-us58wwmp 273 11 two two CD cord-015306-us58wwmp 273 12 standardized standardized JJ cord-015306-us58wwmp 273 13 questionnaires questionnaire NNS cord-015306-us58wwmp 273 14 : : : cord-015306-us58wwmp 273 15 the the DT cord-015306-us58wwmp 273 16 Strengths Strengths NNPS cord-015306-us58wwmp 273 17 and and CC cord-015306-us58wwmp 273 18 Difficulties Difficulties NNPS cord-015306-us58wwmp 273 19 Questionnaire Questionnaire NNP cord-015306-us58wwmp 273 20 ( ( -LRB- cord-015306-us58wwmp 273 21 SDQ SDQ NNP cord-015306-us58wwmp 273 22 ) ) -RRB- cord-015306-us58wwmp 273 23 to to TO cord-015306-us58wwmp 273 24 screen screen VB cord-015306-us58wwmp 273 25 for for IN cord-015306-us58wwmp 273 26 mental mental JJ cord-015306-us58wwmp 273 27 health health NN cord-015306-us58wwmp 273 28 disorders disorder NNS cord-015306-us58wwmp 273 29 and and CC cord-015306-us58wwmp 273 30 the the DT cord-015306-us58wwmp 273 31 Questionnaire Questionnaire NNP cord-015306-us58wwmp 273 32 for for IN cord-015306-us58wwmp 273 33 the the DT cord-015306-us58wwmp 273 34 detection detection NN cord-015306-us58wwmp 273 35 of of IN cord-015306-us58wwmp 273 36 ADHD ADHD NNP cord-015306-us58wwmp 273 37 of of IN cord-015306-us58wwmp 273 38 the the DT cord-015306-us58wwmp 273 39 DSM DSM NNP cord-015306-us58wwmp 273 40 - - HYPH cord-015306-us58wwmp 273 41 IV IV NNP cord-015306-us58wwmp 273 42 psychiatric psychiatric JJ cord-015306-us58wwmp 273 43 disorders disorder NNS cord-015306-us58wwmp 273 44 of of IN cord-015306-us58wwmp 273 45 American American NNP cord-015306-us58wwmp 273 46 Academy Academy NNP cord-015306-us58wwmp 273 47 of of IN cord-015306-us58wwmp 273 48 Psychiatry Psychiatry NNP cord-015306-us58wwmp 273 49 manual manual NN cord-015306-us58wwmp 273 50 . . . cord-015306-us58wwmp 274 1 The the DT cord-015306-us58wwmp 274 2 variables variable NNS cord-015306-us58wwmp 274 3 obtained obtain VBN cord-015306-us58wwmp 274 4 from from IN cord-015306-us58wwmp 274 5 the the DT cord-015306-us58wwmp 274 6 questionnaire questionnaire NN cord-015306-us58wwmp 274 7 responses response NNS cord-015306-us58wwmp 274 8 were be VBD cord-015306-us58wwmp 274 9 compared compare VBN cord-015306-us58wwmp 274 10 between between IN cord-015306-us58wwmp 274 11 the the DT cord-015306-us58wwmp 274 12 two two CD cord-015306-us58wwmp 274 13 groups group NNS cord-015306-us58wwmp 274 14 of of IN cord-015306-us58wwmp 274 15 children child NNS cord-015306-us58wwmp 274 16 using use VBG cord-015306-us58wwmp 274 17 the the DT cord-015306-us58wwmp 274 18 Student Student NNP cord-015306-us58wwmp 274 19 's 's POS cord-015306-us58wwmp 274 20 t t NN cord-015306-us58wwmp 274 21 - - HYPH cord-015306-us58wwmp 274 22 test test NN cord-015306-us58wwmp 274 23 for for IN cord-015306-us58wwmp 274 24 unpaired unpaired JJ cord-015306-us58wwmp 274 25 samples sample NNS cord-015306-us58wwmp 274 26 when when WRB cord-015306-us58wwmp 274 27 variables variable NNS cord-015306-us58wwmp 274 28 were be VBD cord-015306-us58wwmp 274 29 quantitative quantitative JJ cord-015306-us58wwmp 274 30 and and CC cord-015306-us58wwmp 274 31 the the DT cord-015306-us58wwmp 274 32 chi chi JJ cord-015306-us58wwmp 274 33 - - HYPH cord-015306-us58wwmp 274 34 square square JJ cord-015306-us58wwmp 274 35 test test NN cord-015306-us58wwmp 274 36 if if IN cord-015306-us58wwmp 274 37 the the DT cord-015306-us58wwmp 274 38 variables variable NNS cord-015306-us58wwmp 274 39 were be VBD cord-015306-us58wwmp 274 40 qualitative qualitative JJ cord-015306-us58wwmp 274 41 . . . cord-015306-us58wwmp 275 1 It -PRON- PRP cord-015306-us58wwmp 275 2 was be VBD cord-015306-us58wwmp 275 3 considered consider VBN cord-015306-us58wwmp 275 4 significant significant JJ cord-015306-us58wwmp 275 5 when when WRB cord-015306-us58wwmp 275 6 p<0.05 p<0.05 JJ cord-015306-us58wwmp 275 7 Results result NNS cord-015306-us58wwmp 275 8 : : : cord-015306-us58wwmp 275 9 No no DT cord-015306-us58wwmp 275 10 significant significant JJ cord-015306-us58wwmp 275 11 differences difference NNS cord-015306-us58wwmp 275 12 were be VBD cord-015306-us58wwmp 275 13 found find VBN cord-015306-us58wwmp 275 14 between between IN cord-015306-us58wwmp 275 15 the the DT cord-015306-us58wwmp 275 16 two two CD cord-015306-us58wwmp 275 17 groups group NNS cord-015306-us58wwmp 275 18 in in IN cord-015306-us58wwmp 275 19 the the DT cord-015306-us58wwmp 275 20 SDQ SDQ NNP cord-015306-us58wwmp 275 21 questionnaire questionnaire NN cord-015306-us58wwmp 275 22 in in IN cord-015306-us58wwmp 275 23 any any DT cord-015306-us58wwmp 275 24 of of IN cord-015306-us58wwmp 275 25 its -PRON- PRP$ cord-015306-us58wwmp 275 26 sections section NNS cord-015306-us58wwmp 275 27 ( ( -LRB- cord-015306-us58wwmp 275 28 emotional emotional JJ cord-015306-us58wwmp 275 29 symptoms symptom NNS cord-015306-us58wwmp 275 30 , , , cord-015306-us58wwmp 275 31 conduct conduct VB cord-015306-us58wwmp 275 32 problems problem NNS cord-015306-us58wwmp 275 33 , , , cord-015306-us58wwmp 275 34 hyperactivity hyperactivity NN cord-015306-us58wwmp 275 35 , , , cord-015306-us58wwmp 275 36 peer peer NN cord-015306-us58wwmp 275 37 problems problem NNS cord-015306-us58wwmp 275 38 and and CC cord-015306-us58wwmp 275 39 prosocial prosocial JJ cord-015306-us58wwmp 275 40 behavior behavior NN cord-015306-us58wwmp 275 41 ) ) -RRB- cord-015306-us58wwmp 275 42 or or CC cord-015306-us58wwmp 275 43 global global JJ cord-015306-us58wwmp 275 44 assessment assessment NN cord-015306-us58wwmp 275 45 test test NN cord-015306-us58wwmp 275 46 , , , cord-015306-us58wwmp 275 47 in in IN cord-015306-us58wwmp 275 48 which which WDT cord-015306-us58wwmp 275 49 only only RB cord-015306-us58wwmp 275 50 2 2 CD cord-015306-us58wwmp 275 51 patients patient NNS cord-015306-us58wwmp 275 52 of of IN cord-015306-us58wwmp 275 53 each each DT cord-015306-us58wwmp 275 54 group group NN cord-015306-us58wwmp 275 55 had have VBD cord-015306-us58wwmp 275 56 an an DT cord-015306-us58wwmp 275 57 abnormal abnormal JJ cord-015306-us58wwmp 275 58 result result NN cord-015306-us58wwmp 275 59 . . . cord-015306-us58wwmp 276 1 The the DT cord-015306-us58wwmp 276 2 questionnaire questionnaire NN cord-015306-us58wwmp 276 3 for for IN cord-015306-us58wwmp 276 4 the the DT cord-015306-us58wwmp 276 5 detection detection NN cord-015306-us58wwmp 276 6 of of IN cord-015306-us58wwmp 276 7 ADHD ADHD NNP cord-015306-us58wwmp 276 8 , , , cord-015306-us58wwmp 276 9 presented present VBD cord-015306-us58wwmp 276 10 an an DT cord-015306-us58wwmp 276 11 altered alter VBN cord-015306-us58wwmp 276 12 overall overall JJ cord-015306-us58wwmp 276 13 result result NN cord-015306-us58wwmp 276 14 of of IN cord-015306-us58wwmp 276 15 17.18 17.18 CD cord-015306-us58wwmp 276 16 % % NN cord-015306-us58wwmp 276 17 and and CC cord-015306-us58wwmp 276 18 14.06 14.06 CD cord-015306-us58wwmp 276 19 % % NN cord-015306-us58wwmp 276 20 patients patient NNS cord-015306-us58wwmp 276 21 in in IN cord-015306-us58wwmp 276 22 the the DT cord-015306-us58wwmp 276 23 control control NN cord-015306-us58wwmp 276 24 group group NN cord-015306-us58wwmp 276 25 ( ( -LRB- cord-015306-us58wwmp 276 26 p p NN cord-015306-us58wwmp 276 27 = = SYM cord-015306-us58wwmp 276 28 ns ns NNP cord-015306-us58wwmp 276 29 ) ) -RRB- cord-015306-us58wwmp 276 30 . . . cord-015306-us58wwmp 277 1 There there EX cord-015306-us58wwmp 277 2 were be VBD cord-015306-us58wwmp 277 3 also also RB cord-015306-us58wwmp 277 4 no no DT cord-015306-us58wwmp 277 5 differences difference NNS cord-015306-us58wwmp 277 6 between between IN cord-015306-us58wwmp 277 7 the the DT cord-015306-us58wwmp 277 8 two two CD cord-015306-us58wwmp 277 9 groups group NNS cord-015306-us58wwmp 277 10 on on IN cord-015306-us58wwmp 277 11 the the DT cord-015306-us58wwmp 277 12 results result NNS cord-015306-us58wwmp 277 13 of of IN cord-015306-us58wwmp 277 14 this this DT cord-015306-us58wwmp 277 15 test test NN cord-015306-us58wwmp 277 16 concerning concern VBG cord-015306-us58wwmp 277 17 the the DT cord-015306-us58wwmp 277 18 inattention inattention NN cord-015306-us58wwmp 277 19 or or CC cord-015306-us58wwmp 277 20 hyperactivity hyperactivity NN cord-015306-us58wwmp 277 21 - - HYPH cord-015306-us58wwmp 277 22 impulsivity impulsivity NN cord-015306-us58wwmp 277 23 sections section NNS cord-015306-us58wwmp 277 24 . . . cord-015306-us58wwmp 278 1 Conclusion conclusion NN cord-015306-us58wwmp 278 2 : : : cord-015306-us58wwmp 279 1 The the DT cord-015306-us58wwmp 279 2 results result NNS cord-015306-us58wwmp 279 3 of of IN cord-015306-us58wwmp 279 4 the the DT cord-015306-us58wwmp 279 5 application application NN cord-015306-us58wwmp 279 6 of of IN cord-015306-us58wwmp 279 7 questionnaires questionnaire NNS cord-015306-us58wwmp 279 8 to to TO cord-015306-us58wwmp 279 9 detect detect VB cord-015306-us58wwmp 279 10 ADHD ADHD NNP cord-015306-us58wwmp 279 11 and and CC cord-015306-us58wwmp 279 12 other other JJ cord-015306-us58wwmp 279 13 psychiatric psychiatric JJ cord-015306-us58wwmp 279 14 disorders disorder NNS cord-015306-us58wwmp 279 15 in in IN cord-015306-us58wwmp 279 16 children child NNS cord-015306-us58wwmp 279 17 with with IN cord-015306-us58wwmp 279 18 FVD FVD NNP cord-015306-us58wwmp 279 19 are be VBP cord-015306-us58wwmp 279 20 similar similar JJ cord-015306-us58wwmp 279 21 to to IN cord-015306-us58wwmp 279 22 those those DT cord-015306-us58wwmp 279 23 of of IN cord-015306-us58wwmp 279 24 the the DT cord-015306-us58wwmp 279 25 general general JJ cord-015306-us58wwmp 279 26 population population NN cord-015306-us58wwmp 279 27 . . . cord-015306-us58wwmp 280 1 The the DT cord-015306-us58wwmp 280 2 routine routine JJ cord-015306-us58wwmp 280 3 application application NN cord-015306-us58wwmp 280 4 of of IN cord-015306-us58wwmp 280 5 this this DT cord-015306-us58wwmp 280 6 type type NN cord-015306-us58wwmp 280 7 of of IN cord-015306-us58wwmp 280 8 questionnaires questionnaire NNS cord-015306-us58wwmp 280 9 to to IN cord-015306-us58wwmp 280 10 all all PDT cord-015306-us58wwmp 280 11 the the DT cord-015306-us58wwmp 280 12 patients patient NNS cord-015306-us58wwmp 280 13 in in IN cord-015306-us58wwmp 280 14 pediatrics pediatrics NNP cord-015306-us58wwmp 280 15 consultations consultation NNS cord-015306-us58wwmp 280 16 does do VBZ cord-015306-us58wwmp 280 17 not not RB cord-015306-us58wwmp 280 18 seem seem VB cord-015306-us58wwmp 280 19 necessary necessary JJ cord-015306-us58wwmp 280 20 . . . cord-015306-us58wwmp 281 1 Abstract abstract JJ cord-015306-us58wwmp 281 2 # # NN cord-015306-us58wwmp 281 3 P p NN cord-015306-us58wwmp 281 4 - - HYPH cord-015306-us58wwmp 281 5 SAT051 sat051 JJ cord-015306-us58wwmp 281 6 Characterization characterization NN cord-015306-us58wwmp 281 7 of of IN cord-015306-us58wwmp 281 8 voiding void VBG cord-015306-us58wwmp 281 9 dysfunction dysfunction NN cord-015306-us58wwmp 281 10 in in IN cord-015306-us58wwmp 281 11 chidren chidren NNS cord-015306-us58wwmp 281 12 with with IN cord-015306-us58wwmp 281 13 attention attention NN cord-015306-us58wwmp 281 14 deficit deficit NN cord-015306-us58wwmp 281 15 - - HYPH cord-015306-us58wwmp 281 16 hyperactivity hyperactivity NN cord-015306-us58wwmp 281 17 disorder disorder NN cord-015306-us58wwmp 281 18 Jun Jun NNP cord-015306-us58wwmp 281 19 Yonug Yonug NNP cord-015306-us58wwmp 281 20 Kim Kim NNP cord-015306-us58wwmp 281 21 , , , cord-015306-us58wwmp 282 1 Kun Kun NNP cord-015306-us58wwmp 282 2 Hee Hee NNP cord-015306-us58wwmp 282 3 Lee Lee NNP cord-015306-us58wwmp 282 4 , , , cord-015306-us58wwmp 282 5 Jung Jung NNP cord-015306-us58wwmp 282 6 Won Won NNP cord-015306-us58wwmp 282 7 Lee Lee NNP cord-015306-us58wwmp 282 8 Department Department NNP cord-015306-us58wwmp 282 9 of of IN cord-015306-us58wwmp 282 10 Pediatrics Pediatrics NNP cord-015306-us58wwmp 282 11 , , , cord-015306-us58wwmp 282 12 Hallym Hallym NNP cord-015306-us58wwmp 282 13 University University NNP cord-015306-us58wwmp 282 14 Kangnam Kangnam NNP cord-015306-us58wwmp 282 15 Sacred Sacred NNP cord-015306-us58wwmp 282 16 Heart Heart NNP cord-015306-us58wwmp 282 17 Hospital Hospital NNP cord-015306-us58wwmp 282 18 , , , cord-015306-us58wwmp 282 19 Seoul Seoul NNP cord-015306-us58wwmp 282 20 , , , cord-015306-us58wwmp 282 21 Korea Korea NNP cord-015306-us58wwmp 282 22 Objective Objective NNP cord-015306-us58wwmp 282 23 : : : cord-015306-us58wwmp 282 24 Attention attention NN cord-015306-us58wwmp 282 25 deficit deficit NN cord-015306-us58wwmp 282 26 hyperacitivity hyperacitivity NN cord-015306-us58wwmp 282 27 disorder disorder NN cord-015306-us58wwmp 282 28 ( ( -LRB- cord-015306-us58wwmp 282 29 ADHD ADHD NNP cord-015306-us58wwmp 282 30 ) ) -RRB- cord-015306-us58wwmp 282 31 has have VBZ cord-015306-us58wwmp 282 32 been be VBN cord-015306-us58wwmp 282 33 associated associate VBN cord-015306-us58wwmp 282 34 with with IN cord-015306-us58wwmp 282 35 impairment impairment NN cord-015306-us58wwmp 282 36 of of IN cord-015306-us58wwmp 282 37 frontal frontal JJ cord-015306-us58wwmp 282 38 inhibitory inhibitory JJ cord-015306-us58wwmp 282 39 function function NN cord-015306-us58wwmp 282 40 and and CC cord-015306-us58wwmp 282 41 catecholaminergic catecholaminergic NN cord-015306-us58wwmp 282 42 system system NN cord-015306-us58wwmp 282 43 . . . cord-015306-us58wwmp 283 1 ADHD ADHD NNP cord-015306-us58wwmp 283 2 is be VBZ cord-015306-us58wwmp 283 3 diagnosed diagnose VBN cord-015306-us58wwmp 283 4 in in IN cord-015306-us58wwmp 283 5 3~5 3~5 CD cord-015306-us58wwmp 283 6 % % NN cord-015306-us58wwmp 283 7 of of IN cord-015306-us58wwmp 283 8 children child NNS cord-015306-us58wwmp 283 9 . . . cord-015306-us58wwmp 284 1 Children child NNS cord-015306-us58wwmp 284 2 with with IN cord-015306-us58wwmp 284 3 ADHD ADHD NNP cord-015306-us58wwmp 284 4 seem seem VBP cord-015306-us58wwmp 284 5 to to TO cord-015306-us58wwmp 284 6 suffer suffer VB cord-015306-us58wwmp 284 7 from from IN cord-015306-us58wwmp 284 8 various various JJ cord-015306-us58wwmp 284 9 forms form NNS cord-015306-us58wwmp 284 10 of of IN cord-015306-us58wwmp 284 11 urinary urinary JJ cord-015306-us58wwmp 284 12 problems problem NNS cord-015306-us58wwmp 284 13 such such JJ cord-015306-us58wwmp 284 14 as as IN cord-015306-us58wwmp 284 15 nocturnal nocturnal JJ cord-015306-us58wwmp 284 16 enuresis enuresis NN cord-015306-us58wwmp 284 17 , , , cord-015306-us58wwmp 284 18 dysfunctional dysfunctional JJ cord-015306-us58wwmp 284 19 voiding voiding NN cord-015306-us58wwmp 284 20 and and CC cord-015306-us58wwmp 284 21 diurnal diurnal JJ cord-015306-us58wwmp 284 22 incontinence incontinence NN cord-015306-us58wwmp 284 23 . . . cord-015306-us58wwmp 285 1 However however RB cord-015306-us58wwmp 285 2 , , , cord-015306-us58wwmp 285 3 no no DT cord-015306-us58wwmp 285 4 data datum NNS cord-015306-us58wwmp 285 5 exist exist VBP cord-015306-us58wwmp 285 6 to to TO cord-015306-us58wwmp 285 7 confirm confirm VB cord-015306-us58wwmp 285 8 in in IN cord-015306-us58wwmp 285 9 Korean korean JJ cord-015306-us58wwmp 285 10 ADHD ADHD NNP cord-015306-us58wwmp 285 11 children child NNS cord-015306-us58wwmp 285 12 . . . cord-015306-us58wwmp 286 1 We -PRON- PRP cord-015306-us58wwmp 286 2 investigate investigate VBP cord-015306-us58wwmp 286 3 the the DT cord-015306-us58wwmp 286 4 clinical clinical JJ cord-015306-us58wwmp 286 5 findings finding NNS cord-015306-us58wwmp 286 6 of of IN cord-015306-us58wwmp 286 7 voiding void VBG cord-015306-us58wwmp 286 8 dysfunction dysfunction NN cord-015306-us58wwmp 286 9 in in IN cord-015306-us58wwmp 286 10 ADHD ADHD NNP cord-015306-us58wwmp 286 11 children child NNS cord-015306-us58wwmp 286 12 . . . cord-015306-us58wwmp 287 1 Methods method NNS cord-015306-us58wwmp 287 2 : : : cord-015306-us58wwmp 287 3 Between between IN cord-015306-us58wwmp 287 4 October October NNP cord-015306-us58wwmp 287 5 2009 2009 CD cord-015306-us58wwmp 287 6 and and CC cord-015306-us58wwmp 287 7 March March NNP cord-015306-us58wwmp 287 8 2011 2011 CD cord-015306-us58wwmp 287 9 , , , cord-015306-us58wwmp 287 10 a a DT cord-015306-us58wwmp 287 11 total total NN cord-015306-us58wwmp 287 12 of of IN cord-015306-us58wwmp 287 13 63 63 CD cord-015306-us58wwmp 287 14 children child NNS cord-015306-us58wwmp 287 15 ( ( -LRB- cord-015306-us58wwmp 287 16 33 33 CD cord-015306-us58wwmp 287 17 children child NNS cord-015306-us58wwmp 287 18 with with IN cord-015306-us58wwmp 287 19 ADHD ADHD NNP cord-015306-us58wwmp 287 20 and and CC cord-015306-us58wwmp 287 21 the the DT cord-015306-us58wwmp 287 22 other other JJ cord-015306-us58wwmp 287 23 30 30 CD cord-015306-us58wwmp 287 24 children child NNS cord-015306-us58wwmp 287 25 with with IN cord-015306-us58wwmp 287 26 upper upper JJ cord-015306-us58wwmp 287 27 respiratory respiratory JJ cord-015306-us58wwmp 287 28 infection infection NN cord-015306-us58wwmp 287 29 as as IN cord-015306-us58wwmp 287 30 control control NN cord-015306-us58wwmp 287 31 group group NN cord-015306-us58wwmp 287 32 ) ) -RRB- cord-015306-us58wwmp 287 33 were be VBD cord-015306-us58wwmp 287 34 enrolled enrol VBN cord-015306-us58wwmp 287 35 in in IN cord-015306-us58wwmp 287 36 Gangnam Gangnam NNP cord-015306-us58wwmp 287 37 Sacred Sacred NNP cord-015306-us58wwmp 287 38 Heart Heart NNP cord-015306-us58wwmp 287 39 hospital hospital NN cord-015306-us58wwmp 287 40 , , , cord-015306-us58wwmp 287 41 Hallymuniversity Hallymuniversity NNP cord-015306-us58wwmp 287 42 . . . cord-015306-us58wwmp 288 1 ADHD ADHD NNP cord-015306-us58wwmp 288 2 children child NNS cord-015306-us58wwmp 288 3 were be VBD cord-015306-us58wwmp 288 4 diagnosed diagnose VBN cord-015306-us58wwmp 288 5 under under IN cord-015306-us58wwmp 288 6 diagnostic diagnostic JJ cord-015306-us58wwmp 288 7 and and CC cord-015306-us58wwmp 288 8 statistical statistical JJ cord-015306-us58wwmp 288 9 manual manual NN cord-015306-us58wwmp 288 10 of of IN cord-015306-us58wwmp 288 11 mental mental JJ cord-015306-us58wwmp 288 12 disorders disorder NNS cord-015306-us58wwmp 288 13 ( ( -LRB- cord-015306-us58wwmp 288 14 DSM)-IV dsm)-iv CD cord-015306-us58wwmp 288 15 criteria criterion NNS cord-015306-us58wwmp 288 16 . . . cord-015306-us58wwmp 289 1 A a DT cord-015306-us58wwmp 289 2 comprehensive comprehensive JJ cord-015306-us58wwmp 289 3 survey survey NN cord-015306-us58wwmp 289 4 of of IN cord-015306-us58wwmp 289 5 voiding void VBG cord-015306-us58wwmp 289 6 and and CC cord-015306-us58wwmp 289 7 defecating defecating NN cord-015306-us58wwmp 289 8 were be VBD cord-015306-us58wwmp 289 9 administered administer VBN cord-015306-us58wwmp 289 10 . . . cord-015306-us58wwmp 290 1 Results result NNS cord-015306-us58wwmp 290 2 : : : cord-015306-us58wwmp 291 1 The the DT cord-015306-us58wwmp 291 2 patient patient NN cord-015306-us58wwmp 291 3 group group NN cord-015306-us58wwmp 291 4 included include VBD cord-015306-us58wwmp 291 5 28 28 CD cord-015306-us58wwmp 291 6 boys boy NNS cord-015306-us58wwmp 291 7 and and CC cord-015306-us58wwmp 291 8 5 5 CD cord-015306-us58wwmp 291 9 girls girl NNS cord-015306-us58wwmp 291 10 , , , cord-015306-us58wwmp 291 11 and and CC cord-015306-us58wwmp 291 12 the the DT cord-015306-us58wwmp 291 13 control control NN cord-015306-us58wwmp 291 14 group group NN cord-015306-us58wwmp 291 15 15 15 CD cord-015306-us58wwmp 291 16 boys boy NNS cord-015306-us58wwmp 291 17 and and CC cord-015306-us58wwmp 291 18 15 15 CD cord-015306-us58wwmp 291 19 girls girl NNS cord-015306-us58wwmp 291 20 . . . cord-015306-us58wwmp 292 1 Mean mean JJ cord-015306-us58wwmp 292 2 age age NN cord-015306-us58wwmp 292 3 were be VBD cord-015306-us58wwmp 292 4 9.09+/−2.8 9.09+/−2.8 CD cord-015306-us58wwmp 292 5 year year NN cord-015306-us58wwmp 292 6 in in IN cord-015306-us58wwmp 292 7 ADHD ADHD NNP cord-015306-us58wwmp 292 8 group group NN cord-015306-us58wwmp 292 9 and and CC cord-015306-us58wwmp 292 10 8.58+/−3.1 8.58+/−3.1 CD cord-015306-us58wwmp 292 11 in in IN cord-015306-us58wwmp 292 12 control control NN cord-015306-us58wwmp 292 13 group group NN cord-015306-us58wwmp 292 14 . . . cord-015306-us58wwmp 293 1 Children child NNS cord-015306-us58wwmp 293 2 with with IN cord-015306-us58wwmp 293 3 ADHD ADHD NNP cord-015306-us58wwmp 293 4 had have VBD cord-015306-us58wwmp 293 5 statistically statistically RB cord-015306-us58wwmp 293 6 significant significant JJ cord-015306-us58wwmp 293 7 higher high JJR cord-015306-us58wwmp 293 8 incidence incidence NN cord-015306-us58wwmp 293 9 of of IN cord-015306-us58wwmp 293 10 enuresis enuresis NN cord-015306-us58wwmp 293 11 ( ( -LRB- cord-015306-us58wwmp 293 12 P=0.017 P=0.017 NNS cord-015306-us58wwmp 293 13 ) ) -RRB- cord-015306-us58wwmp 293 14 , , , cord-015306-us58wwmp 293 15 urgency urgency NN cord-015306-us58wwmp 293 16 ( ( -LRB- cord-015306-us58wwmp 293 17 P=0.017 P=0.017 NNS cord-015306-us58wwmp 293 18 ) ) -RRB- cord-015306-us58wwmp 293 19 , , , cord-015306-us58wwmp 293 20 urge urge VBP cord-015306-us58wwmp 293 21 incontinence incontinence NN cord-015306-us58wwmp 293 22 ( ( -LRB- cord-015306-us58wwmp 293 23 P=0.033 P=0.033 NNP cord-015306-us58wwmp 293 24 ) ) -RRB- cord-015306-us58wwmp 293 25 and and CC cord-015306-us58wwmp 293 26 constipation constipation NN cord-015306-us58wwmp 293 27 ( ( -LRB- cord-015306-us58wwmp 293 28 P=0.007 p=0.007 NN cord-015306-us58wwmp 293 29 ) ) -RRB- cord-015306-us58wwmp 293 30 . . . cord-015306-us58wwmp 294 1 There there EX cord-015306-us58wwmp 294 2 was be VBD cord-015306-us58wwmp 294 3 no no DT cord-015306-us58wwmp 294 4 significant significant JJ cord-015306-us58wwmp 294 5 differences difference NNS cord-015306-us58wwmp 294 6 in in IN cord-015306-us58wwmp 294 7 straining strain VBG cord-015306-us58wwmp 294 8 , , , cord-015306-us58wwmp 294 9 intermitteny intermitteny NNP cord-015306-us58wwmp 294 10 , , , cord-015306-us58wwmp 294 11 holding hold VBG cord-015306-us58wwmp 294 12 maneuvers maneuver NNS cord-015306-us58wwmp 294 13 ( ( -LRB- cord-015306-us58wwmp 294 14 P>0.05 P>0.05 NNP cord-015306-us58wwmp 294 15 ) ) -RRB- cord-015306-us58wwmp 294 16 . . . cord-015306-us58wwmp 295 1 Conclusion conclusion NN cord-015306-us58wwmp 295 2 : : : cord-015306-us58wwmp 295 3 Children child NNS cord-015306-us58wwmp 295 4 with with IN cord-015306-us58wwmp 295 5 ADHD ADHD NNP cord-015306-us58wwmp 295 6 in in IN cord-015306-us58wwmp 295 7 Korea Korea NNP cord-015306-us58wwmp 295 8 have have VBP cord-015306-us58wwmp 295 9 significantly significantly RB cord-015306-us58wwmp 295 10 higher high JJR cord-015306-us58wwmp 295 11 rates rate NNS cord-015306-us58wwmp 295 12 of of IN cord-015306-us58wwmp 295 13 enuresis enuresis NN cord-015306-us58wwmp 295 14 , , , cord-015306-us58wwmp 295 15 urgency urgency NN cord-015306-us58wwmp 295 16 , , , cord-015306-us58wwmp 295 17 urge urge VBP cord-015306-us58wwmp 295 18 incontinence incontinence NN cord-015306-us58wwmp 295 19 and and CC cord-015306-us58wwmp 295 20 constipation constipation NN cord-015306-us58wwmp 295 21 than than IN cord-015306-us58wwmp 295 22 those those DT cord-015306-us58wwmp 295 23 without without IN cord-015306-us58wwmp 295 24 ADHD ADHD NNP cord-015306-us58wwmp 295 25 . . . cord-015306-us58wwmp 296 1 The the DT cord-015306-us58wwmp 296 2 psychological psychological JJ cord-015306-us58wwmp 296 3 correlates correlate NNS cord-015306-us58wwmp 296 4 of of IN cord-015306-us58wwmp 296 5 primary primary JJ cord-015306-us58wwmp 296 6 nocturnal nocturnal JJ cord-015306-us58wwmp 296 7 enuresis enuresis NN cord-015306-us58wwmp 296 8 Weiran Weiran NNP cord-015306-us58wwmp 296 9 zhou zhou NNP cord-015306-us58wwmp 296 10 , , , cord-015306-us58wwmp 296 11 Xiaomei Xiaomei NNP cord-015306-us58wwmp 296 12 liu liu NNP cord-015306-us58wwmp 296 13 , , , cord-015306-us58wwmp 296 14 Ying Ying NNP cord-015306-us58wwmp 296 15 shen shen NNP cord-015306-us58wwmp 296 16 Nephrology Nephrology NNP cord-015306-us58wwmp 296 17 , , , cord-015306-us58wwmp 296 18 Beijing Beijing NNP cord-015306-us58wwmp 296 19 Children Children NNP cord-015306-us58wwmp 296 20 's 's POS cord-015306-us58wwmp 296 21 Hospital Hospital NNP cord-015306-us58wwmp 296 22 , , , cord-015306-us58wwmp 296 23 Beijing Beijing NNP cord-015306-us58wwmp 296 24 , , , cord-015306-us58wwmp 297 1 China China NNP cord-015306-us58wwmp 297 2 Objective Objective NNP cord-015306-us58wwmp 297 3 : : : cord-015306-us58wwmp 298 1 Previous previous JJ cord-015306-us58wwmp 298 2 studies study NNS cord-015306-us58wwmp 298 3 based base VBN cord-015306-us58wwmp 298 4 on on IN cord-015306-us58wwmp 298 5 clinical clinical JJ cord-015306-us58wwmp 298 6 samples sample NNS cord-015306-us58wwmp 298 7 have have VBP cord-015306-us58wwmp 298 8 reported report VBN cord-015306-us58wwmp 298 9 that that IN cord-015306-us58wwmp 298 10 enuresis enuresis NN cord-015306-us58wwmp 298 11 in in IN cord-015306-us58wwmp 298 12 children child NNS cord-015306-us58wwmp 298 13 is be VBZ cord-015306-us58wwmp 298 14 associated associate VBN cord-015306-us58wwmp 298 15 with with IN cord-015306-us58wwmp 298 16 behavioural behavioural JJ cord-015306-us58wwmp 298 17 problems problem NNS cord-015306-us58wwmp 298 18 and and CC cord-015306-us58wwmp 298 19 reduced reduce VBN cord-015306-us58wwmp 298 20 self self NN cord-015306-us58wwmp 298 21 - - HYPH cord-015306-us58wwmp 298 22 esteem esteem NN cord-015306-us58wwmp 298 23 , , , cord-015306-us58wwmp 298 24 anxiety anxiety NN cord-015306-us58wwmp 298 25 , , , cord-015306-us58wwmp 298 26 but but CC cord-015306-us58wwmp 298 27 the the DT cord-015306-us58wwmp 298 28 relationship relationship NN cord-015306-us58wwmp 298 29 remains remain VBZ cord-015306-us58wwmp 298 30 controversial controversial JJ cord-015306-us58wwmp 298 31 . . . cord-015306-us58wwmp 299 1 This this DT cord-015306-us58wwmp 299 2 study study NN cord-015306-us58wwmp 299 3 investigated investigate VBD cord-015306-us58wwmp 299 4 psychological psychological JJ cord-015306-us58wwmp 299 5 correlates correlate NNS cord-015306-us58wwmp 299 6 of of IN cord-015306-us58wwmp 299 7 enuresis enuresis NN cord-015306-us58wwmp 299 8 in in IN cord-015306-us58wwmp 299 9 a a DT cord-015306-us58wwmp 299 10 group group NN cord-015306-us58wwmp 299 11 of of IN cord-015306-us58wwmp 299 12 children child NNS cord-015306-us58wwmp 299 13 suffering suffer VBG cord-015306-us58wwmp 299 14 primary primary JJ cord-015306-us58wwmp 299 15 nocturnal nocturnal JJ cord-015306-us58wwmp 299 16 enuresis(PNE enuresis(PNE NNS cord-015306-us58wwmp 299 17 ) ) -RRB- cord-015306-us58wwmp 299 18 . . . cord-015306-us58wwmp 300 1 Methods method NNS cord-015306-us58wwmp 300 2 : : : cord-015306-us58wwmp 301 1 This this DT cord-015306-us58wwmp 301 2 survey survey NN cord-015306-us58wwmp 301 3 involved involve VBD cord-015306-us58wwmp 301 4 98 98 CD cord-015306-us58wwmp 301 5 parents parent NNS cord-015306-us58wwmp 301 6 and and CC cord-015306-us58wwmp 301 7 their -PRON- PRP$ cord-015306-us58wwmp 301 8 children child NNS cord-015306-us58wwmp 301 9 with with IN cord-015306-us58wwmp 301 10 PNE PNE NNP cord-015306-us58wwmp 301 11 aged age VBN cord-015306-us58wwmp 301 12 7 7 CD cord-015306-us58wwmp 301 13 - - SYM cord-015306-us58wwmp 301 14 14 14 CD cord-015306-us58wwmp 301 15 years year NNS cord-015306-us58wwmp 301 16 . . . cord-015306-us58wwmp 302 1 Clinical clinical JJ cord-015306-us58wwmp 302 2 datas data NNS cord-015306-us58wwmp 302 3 of of IN cord-015306-us58wwmp 302 4 enuresis enuresis NN cord-015306-us58wwmp 302 5 were be VBD cord-015306-us58wwmp 302 6 collected collect VBN cord-015306-us58wwmp 302 7 through through IN cord-015306-us58wwmp 302 8 parents parent NNS cord-015306-us58wwmp 302 9 ' ' POS cord-015306-us58wwmp 302 10 reports report NNS cord-015306-us58wwmp 302 11 and and CC cord-015306-us58wwmp 302 12 individual individual JJ cord-015306-us58wwmp 302 13 administrations administration NNS cord-015306-us58wwmp 302 14 to to IN cord-015306-us58wwmp 302 15 all all DT cord-015306-us58wwmp 302 16 children child NNS cord-015306-us58wwmp 302 17 . . . cord-015306-us58wwmp 303 1 Parents parent NNS cord-015306-us58wwmp 303 2 completed complete VBD cord-015306-us58wwmp 303 3 the the DT cord-015306-us58wwmp 303 4 Child Child NNP cord-015306-us58wwmp 303 5 Behaviour Behaviour NNP cord-015306-us58wwmp 303 6 Checklist Checklist NNP cord-015306-us58wwmp 303 7 . . . cord-015306-us58wwmp 304 1 Children child NNS cord-015306-us58wwmp 304 2 completed complete VBD cord-015306-us58wwmp 304 3 Piers Piers NNP cord-015306-us58wwmp 304 4 Harris Harris NNP cord-015306-us58wwmp 304 5 Children'sSelf children'sself PRP cord-015306-us58wwmp 304 6 concept concept NN cord-015306-us58wwmp 304 7 Scale Scale NNP cord-015306-us58wwmp 304 8 , , , cord-015306-us58wwmp 304 9 the the DT cord-015306-us58wwmp 304 10 Screen Screen NNP cord-015306-us58wwmp 304 11 for for IN cord-015306-us58wwmp 304 12 Child Child NNP cord-015306-us58wwmp 304 13 Anxiety anxiety NN cord-015306-us58wwmp 304 14 - - HYPH cord-015306-us58wwmp 304 15 Related relate VBN cord-015306-us58wwmp 304 16 Emotional emotional JJ cord-015306-us58wwmp 304 17 Disorders disorder NNS cord-015306-us58wwmp 304 18 ( ( -LRB- cord-015306-us58wwmp 304 19 SCARED)and SCARED)and NNP cord-015306-us58wwmp 304 20 Depression Depression NNP cord-015306-us58wwmp 304 21 Self self NN cord-015306-us58wwmp 304 22 Rating Rating NNP cord-015306-us58wwmp 304 23 Scale scale NN cord-015306-us58wwmp 304 24 for for IN cord-015306-us58wwmp 304 25 Children child NNS cord-015306-us58wwmp 304 26 ( ( -LRB- cord-015306-us58wwmp 304 27 DSRSC DSRSC NNP cord-015306-us58wwmp 304 28 ) ) -RRB- cord-015306-us58wwmp 304 29 . . . cord-015306-us58wwmp 305 1 Results result NNS cord-015306-us58wwmp 305 2 : : : cord-015306-us58wwmp 306 1 Of of IN cord-015306-us58wwmp 306 2 the the DT cord-015306-us58wwmp 306 3 98 98 CD cord-015306-us58wwmp 306 4 children child NNS cord-015306-us58wwmp 306 5 , , , cord-015306-us58wwmp 306 6 60 60 CD cord-015306-us58wwmp 306 7 are be VBP cord-015306-us58wwmp 307 1 boys boy NNS cord-015306-us58wwmp 307 2 and and CC cord-015306-us58wwmp 307 3 38 38 CD cord-015306-us58wwmp 307 4 are be VBP cord-015306-us58wwmp 307 5 girls girl NNS cord-015306-us58wwmp 307 6 . . . cord-015306-us58wwmp 308 1 65 65 CD cord-015306-us58wwmp 308 2 are be VBP cord-015306-us58wwmp 308 3 monosymptomatic monosymptomatic JJ cord-015306-us58wwmp 308 4 primary primary JJ cord-015306-us58wwmp 308 5 nocturnal nocturnal JJ cord-015306-us58wwmp 308 6 enuresis enuresis NN cord-015306-us58wwmp 309 1 and and CC cord-015306-us58wwmp 309 2 , , , cord-015306-us58wwmp 309 3 33 33 CD cord-015306-us58wwmp 309 4 are be VBP cord-015306-us58wwmp 309 5 nonmonosymptomatic nonmonosymptomatic JJ cord-015306-us58wwmp 309 6 . . . cord-015306-us58wwmp 310 1 72 72 CD cord-015306-us58wwmp 310 2 children child NNS cord-015306-us58wwmp 310 3 accord accord VBP cord-015306-us58wwmp 310 4 with with IN cord-015306-us58wwmp 310 5 the the DT cord-015306-us58wwmp 310 6 severest severe JJS cord-015306-us58wwmp 310 7 form form NN cord-015306-us58wwmp 310 8 of of IN cord-015306-us58wwmp 310 9 bedwetting(>=7 bedwetting(>=7 CD cord-015306-us58wwmp 310 10 times time NNS cord-015306-us58wwmp 310 11 / / SYM cord-015306-us58wwmp 310 12 week week NN cord-015306-us58wwmp 310 13 ) ) -RRB- cord-015306-us58wwmp 310 14 . . . cord-015306-us58wwmp 311 1 64.3%(n=63)children 64.3%(n=63)children CD cord-015306-us58wwmp 311 2 have have VBP cord-015306-us58wwmp 311 3 behaviour behaviour NN cord-015306-us58wwmp 311 4 problems problem NNS cord-015306-us58wwmp 311 5 and and CC cord-015306-us58wwmp 311 6 , , , cord-015306-us58wwmp 311 7 girls girl NNS cord-015306-us58wwmp 311 8 get get VBP cord-015306-us58wwmp 311 9 higher high JJR cord-015306-us58wwmp 311 10 scores score NNS cord-015306-us58wwmp 311 11 in in IN cord-015306-us58wwmp 311 12 withdraw withdraw NN cord-015306-us58wwmp 311 13 and and CC cord-015306-us58wwmp 311 14 internalizing internalize VBG cord-015306-us58wwmp 311 15 problems problem NNS cord-015306-us58wwmp 311 16 than than IN cord-015306-us58wwmp 311 17 boys boy NNS cord-015306-us58wwmp 311 18 . . . cord-015306-us58wwmp 312 1 Boys boy NNS cord-015306-us58wwmp 312 2 are be VBP cord-015306-us58wwmp 312 3 more more RBR cord-015306-us58wwmp 312 4 aggressive aggressive JJ cord-015306-us58wwmp 312 5 . . . cord-015306-us58wwmp 313 1 42.9%(n=42 42.9%(n=42 LS cord-015306-us58wwmp 313 2 ) ) -RRB- cord-015306-us58wwmp 313 3 get get VB cord-015306-us58wwmp 313 4 positive positive JJ cord-015306-us58wwmp 313 5 results result NNS cord-015306-us58wwmp 313 6 through through IN cord-015306-us58wwmp 313 7 SCARED SCARED NNP cord-015306-us58wwmp 313 8 . . . cord-015306-us58wwmp 314 1 9.2%(n=9 9.2%(n=9 LS cord-015306-us58wwmp 314 2 ) ) -RRB- cord-015306-us58wwmp 314 3 get get VBP cord-015306-us58wwmp 314 4 positive positive JJ cord-015306-us58wwmp 314 5 results result NNS cord-015306-us58wwmp 314 6 in in IN cord-015306-us58wwmp 314 7 DSRSC DSRSC NNP cord-015306-us58wwmp 314 8 . . . cord-015306-us58wwmp 315 1 Children child NNS cord-015306-us58wwmp 315 2 with with IN cord-015306-us58wwmp 315 3 the the DT cord-015306-us58wwmp 315 4 severest severe JJS cord-015306-us58wwmp 315 5 form form NN cord-015306-us58wwmp 315 6 of of IN cord-015306-us58wwmp 315 7 bedwetting bedwetting NN cord-015306-us58wwmp 315 8 are be VBP cord-015306-us58wwmp 315 9 likely likely JJ cord-015306-us58wwmp 315 10 to to TO cord-015306-us58wwmp 315 11 have have VB cord-015306-us58wwmp 315 12 more more RBR cord-015306-us58wwmp 315 13 complex complex JJ cord-015306-us58wwmp 315 14 form form NN cord-015306-us58wwmp 315 15 of of IN cord-015306-us58wwmp 315 16 psychological psychological JJ cord-015306-us58wwmp 315 17 problems problem NNS cord-015306-us58wwmp 315 18 . . . cord-015306-us58wwmp 316 1 They -PRON- PRP cord-015306-us58wwmp 316 2 have have VBP cord-015306-us58wwmp 316 3 greater great JJR cord-015306-us58wwmp 316 4 social social JJ cord-015306-us58wwmp 316 5 problems problem NNS cord-015306-us58wwmp 316 6 , , , cord-015306-us58wwmp 316 7 get get VB cord-015306-us58wwmp 316 8 higher high JJR cord-015306-us58wwmp 316 9 scores score NNS cord-015306-us58wwmp 316 10 in in IN cord-015306-us58wwmp 316 11 behaviour behaviour NN cord-015306-us58wwmp 316 12 problem problem NN cord-015306-us58wwmp 316 13 ( ( -LRB- cord-015306-us58wwmp 316 14 P=0.026 P=0.026 NNP cord-015306-us58wwmp 316 15 ) ) -RRB- cord-015306-us58wwmp 316 16 and and CC cord-015306-us58wwmp 316 17 lower low JJR cord-015306-us58wwmp 316 18 scores score NNS cord-015306-us58wwmp 316 19 in in IN cord-015306-us58wwmp 316 20 Piers Piers NNP cord-015306-us58wwmp 316 21 Harris Harris NNP cord-015306-us58wwmp 316 22 Children Children NNP cord-015306-us58wwmp 316 23 's 's POS cord-015306-us58wwmp 316 24 Self Self NNP cord-015306-us58wwmp 316 25 concept concept NN cord-015306-us58wwmp 316 26 Scale scale NN cord-015306-us58wwmp 316 27 ( ( -LRB- cord-015306-us58wwmp 316 28 P=0.034 P=0.034 NNP cord-015306-us58wwmp 316 29 ) ) -RRB- cord-015306-us58wwmp 316 30 . . . cord-015306-us58wwmp 317 1 But but CC cord-015306-us58wwmp 317 2 children child NNS cord-015306-us58wwmp 317 3 with with IN cord-015306-us58wwmp 317 4 or or CC cord-015306-us58wwmp 317 5 without without IN cord-015306-us58wwmp 317 6 the the DT cord-015306-us58wwmp 317 7 severest severe JJS cord-015306-us58wwmp 317 8 form form NN cord-015306-us58wwmp 317 9 of of IN cord-015306-us58wwmp 317 10 bedwetting bedwetting NN cord-015306-us58wwmp 317 11 have have VBP cord-015306-us58wwmp 317 12 no no DT cord-015306-us58wwmp 317 13 significant significant JJ cord-015306-us58wwmp 317 14 difference difference NN cord-015306-us58wwmp 317 15 in in IN cord-015306-us58wwmp 317 16 SCARED SCARED NNP cord-015306-us58wwmp 317 17 . . . cord-015306-us58wwmp 318 1 MNE MNE NNP cord-015306-us58wwmp 318 2 have have VBP cord-015306-us58wwmp 318 3 no no DT cord-015306-us58wwmp 318 4 significant significant JJ cord-015306-us58wwmp 318 5 difference difference NN cord-015306-us58wwmp 318 6 with with IN cord-015306-us58wwmp 318 7 NMNE NMNE NNP cord-015306-us58wwmp 318 8 in in IN cord-015306-us58wwmp 318 9 scores score NNS cord-015306-us58wwmp 318 10 of of IN cord-015306-us58wwmp 318 11 all all PDT cord-015306-us58wwmp 318 12 the the DT cord-015306-us58wwmp 318 13 three three CD cord-015306-us58wwmp 318 14 children child NNS cord-015306-us58wwmp 318 15 's 's POS cord-015306-us58wwmp 318 16 self self NN cord-015306-us58wwmp 318 17 - - HYPH cord-015306-us58wwmp 318 18 evaluated evaluate VBN cord-015306-us58wwmp 318 19 scales scale NNS cord-015306-us58wwmp 318 20 . . . cord-015306-us58wwmp 319 1 Conclusion conclusion NN cord-015306-us58wwmp 319 2 : : : cord-015306-us58wwmp 319 3 Most Most JJS cord-015306-us58wwmp 319 4 children child NNS cord-015306-us58wwmp 319 5 with with IN cord-015306-us58wwmp 319 6 PNE PNE NNP cord-015306-us58wwmp 319 7 had have VBD cord-015306-us58wwmp 319 8 different different JJ cord-015306-us58wwmp 319 9 psychological psychological JJ cord-015306-us58wwmp 319 10 problems problem NNS cord-015306-us58wwmp 319 11 . . . cord-015306-us58wwmp 320 1 The the DT cord-015306-us58wwmp 320 2 severer severe JJR cord-015306-us58wwmp 320 3 the the DT cord-015306-us58wwmp 320 4 symptoms symptom NNS cord-015306-us58wwmp 320 5 are be VBP cord-015306-us58wwmp 320 6 , , , cord-015306-us58wwmp 320 7 the the DT cord-015306-us58wwmp 320 8 more more RBR cord-015306-us58wwmp 320 9 complex complex JJ cord-015306-us58wwmp 320 10 the the DT cord-015306-us58wwmp 320 11 psychological psychological JJ cord-015306-us58wwmp 320 12 correlates correlate NNS cord-015306-us58wwmp 320 13 are be VBP cord-015306-us58wwmp 320 14 . . . cord-015306-us58wwmp 321 1 These these DT cord-015306-us58wwmp 321 2 preliminary preliminary JJ cord-015306-us58wwmp 321 3 findings finding NNS cord-015306-us58wwmp 321 4 support support VBP cord-015306-us58wwmp 321 5 the the DT cord-015306-us58wwmp 321 6 view view NN cord-015306-us58wwmp 321 7 of of IN cord-015306-us58wwmp 321 8 enuresis enuresis NN cord-015306-us58wwmp 321 9 closely closely RB cord-015306-us58wwmp 321 10 related relate VBN cord-015306-us58wwmp 321 11 with with IN cord-015306-us58wwmp 321 12 psychological psychological JJ cord-015306-us58wwmp 321 13 problems problem NNS cord-015306-us58wwmp 321 14 . . . cord-015306-us58wwmp 322 1 Psychological psychological JJ cord-015306-us58wwmp 322 2 problems problem NNS cord-015306-us58wwmp 322 3 are be VBP cord-015306-us58wwmp 322 4 affected affect VBN cord-015306-us58wwmp 322 5 by by IN cord-015306-us58wwmp 322 6 many many JJ cord-015306-us58wwmp 322 7 factors factor NNS cord-015306-us58wwmp 322 8 except except IN cord-015306-us58wwmp 322 9 for for IN cord-015306-us58wwmp 322 10 enuresis enuresis NN cord-015306-us58wwmp 322 11 , , , cord-015306-us58wwmp 322 12 so so RB cord-015306-us58wwmp 322 13 further further JJ cord-015306-us58wwmp 322 14 researches research NNS cord-015306-us58wwmp 322 15 need need VBP cord-015306-us58wwmp 322 16 to to TO cord-015306-us58wwmp 322 17 be be VB cord-015306-us58wwmp 322 18 conducted conduct VBN cord-015306-us58wwmp 322 19 to to TO cord-015306-us58wwmp 322 20 determine determine VB cord-015306-us58wwmp 322 21 whether whether IN cord-015306-us58wwmp 322 22 there there EX cord-015306-us58wwmp 322 23 is be VBZ cord-015306-us58wwmp 322 24 a a DT cord-015306-us58wwmp 322 25 causal causal JJ cord-015306-us58wwmp 322 26 relationship relationship NN cord-015306-us58wwmp 322 27 between between IN cord-015306-us58wwmp 322 28 psychopathology psychopathology NN cord-015306-us58wwmp 322 29 and and CC cord-015306-us58wwmp 322 30 enuresis enuresis NN cord-015306-us58wwmp 322 31 . . . cord-015306-us58wwmp 323 1 The the DT cord-015306-us58wwmp 323 2 current current JJ cord-015306-us58wwmp 323 3 situation situation NN cord-015306-us58wwmp 323 4 of of IN cord-015306-us58wwmp 323 5 treatment treatment NN cord-015306-us58wwmp 323 6 of of IN cord-015306-us58wwmp 323 7 primary primary JJ cord-015306-us58wwmp 323 8 nocturnal nocturnal JJ cord-015306-us58wwmp 323 9 enuresis enuresis NN cord-015306-us58wwmp 323 10 in in IN cord-015306-us58wwmp 323 11 children child NNS cord-015306-us58wwmp 323 12 Xiaomei Xiaomei NNP cord-015306-us58wwmp 323 13 liu liu NNP cord-015306-us58wwmp 323 14 , , , cord-015306-us58wwmp 323 15 Lu Lu NNP cord-015306-us58wwmp 323 16 chen chen NNP cord-015306-us58wwmp 323 17 , , , cord-015306-us58wwmp 323 18 Weiran Weiran NNP cord-015306-us58wwmp 323 19 zhou zhou NNP cord-015306-us58wwmp 323 20 Nephrology Nephrology NNP cord-015306-us58wwmp 323 21 , , , cord-015306-us58wwmp 323 22 Beijing Beijing NNP cord-015306-us58wwmp 323 23 Children Children NNP cord-015306-us58wwmp 323 24 's 's POS cord-015306-us58wwmp 323 25 Hospital Hospital NNP cord-015306-us58wwmp 323 26 , , , cord-015306-us58wwmp 323 27 Beijing Beijing NNP cord-015306-us58wwmp 323 28 , , , cord-015306-us58wwmp 324 1 China China NNP cord-015306-us58wwmp 324 2 Objective Objective NNP cord-015306-us58wwmp 324 3 : : : cord-015306-us58wwmp 325 1 We -PRON- PRP cord-015306-us58wwmp 325 2 would would MD cord-015306-us58wwmp 325 3 like like VB cord-015306-us58wwmp 325 4 to to TO cord-015306-us58wwmp 325 5 discuss discuss VB cord-015306-us58wwmp 325 6 the the DT cord-015306-us58wwmp 325 7 treatment treatment NN cord-015306-us58wwmp 325 8 of of IN cord-015306-us58wwmp 325 9 primary primary JJ cord-015306-us58wwmp 325 10 nocturnal nocturnal JJ cord-015306-us58wwmp 325 11 enuresis enuresis NN cord-015306-us58wwmp 325 12 in in IN cord-015306-us58wwmp 325 13 children child NNS cord-015306-us58wwmp 325 14 . . . cord-015306-us58wwmp 326 1 Methods method NNS cord-015306-us58wwmp 326 2 : : : cord-015306-us58wwmp 326 3 Children child NNS cord-015306-us58wwmp 326 4 , , , cord-015306-us58wwmp 326 5 diagnosed diagnose VBN cord-015306-us58wwmp 326 6 with with IN cord-015306-us58wwmp 326 7 primary primary JJ cord-015306-us58wwmp 326 8 nocturnal nocturnal JJ cord-015306-us58wwmp 326 9 enuresis enuresis NN cord-015306-us58wwmp 326 10 , , , cord-015306-us58wwmp 326 11 paid pay VBN cord-015306-us58wwmp 326 12 outpatient outpatient NN cord-015306-us58wwmp 326 13 visits visit NNS cord-015306-us58wwmp 326 14 to to IN cord-015306-us58wwmp 326 15 Beijing Beijing NNP cord-015306-us58wwmp 326 16 Children Children NNP cord-015306-us58wwmp 326 17 's 's POS cord-015306-us58wwmp 326 18 Hospital Hospital NNP cord-015306-us58wwmp 326 19 from from IN cord-015306-us58wwmp 326 20 January January NNP cord-015306-us58wwmp 326 21 2011 2011 CD cord-015306-us58wwmp 326 22 to to IN cord-015306-us58wwmp 326 23 May May NNP cord-015306-us58wwmp 326 24 2012 2012 CD cord-015306-us58wwmp 326 25 , , , cord-015306-us58wwmp 326 26 are be VBP cord-015306-us58wwmp 326 27 enrolled enrol VBN cord-015306-us58wwmp 326 28 in in IN cord-015306-us58wwmp 326 29 the the DT cord-015306-us58wwmp 326 30 study study NN cord-015306-us58wwmp 326 31 . . . cord-015306-us58wwmp 327 1 The the DT cord-015306-us58wwmp 327 2 information information NN cord-015306-us58wwmp 327 3 of of IN cord-015306-us58wwmp 327 4 previous previous JJ cord-015306-us58wwmp 327 5 clinical clinical JJ cord-015306-us58wwmp 327 6 experience experience NN cord-015306-us58wwmp 327 7 , , , cord-015306-us58wwmp 327 8 compliance compliance NN cord-015306-us58wwmp 327 9 and and CC cord-015306-us58wwmp 327 10 expected expect VBN cord-015306-us58wwmp 327 11 treatment treatment NN cord-015306-us58wwmp 327 12 goals goal NNS cord-015306-us58wwmp 327 13 are be VBP cord-015306-us58wwmp 327 14 collected collect VBN cord-015306-us58wwmp 327 15 and and CC cord-015306-us58wwmp 327 16 analyzed analyze VBN cord-015306-us58wwmp 327 17 . . . cord-015306-us58wwmp 328 1 Results result NNS cord-015306-us58wwmp 328 2 : : : cord-015306-us58wwmp 328 3 623 623 CD cord-015306-us58wwmp 328 4 children child NNS cord-015306-us58wwmp 328 5 , , , cord-015306-us58wwmp 328 6 with with IN cord-015306-us58wwmp 328 7 the the DT cord-015306-us58wwmp 328 8 mean mean JJ cord-015306-us58wwmp 328 9 age age NN cord-015306-us58wwmp 328 10 of of IN cord-015306-us58wwmp 328 11 8.69±2.33 8.69±2.33 CD cord-015306-us58wwmp 328 12 are be VBP cord-015306-us58wwmp 328 13 enrolled enrol VBN cord-015306-us58wwmp 328 14 . . . cord-015306-us58wwmp 329 1 449 449 CD cord-015306-us58wwmp 329 2 children child NNS cord-015306-us58wwmp 329 3 have have VBP cord-015306-us58wwmp 329 4 visited visit VBN cord-015306-us58wwmp 329 5 doctors doctor NNS cord-015306-us58wwmp 329 6 before before RB cord-015306-us58wwmp 329 7 , , , cord-015306-us58wwmp 329 8 295 295 CD cord-015306-us58wwmp 329 9 have have VBP cord-015306-us58wwmp 329 10 unsatisfied unsatisfie VBN cord-015306-us58wwmp 329 11 clinical clinical JJ cord-015306-us58wwmp 329 12 experience experience NN cord-015306-us58wwmp 329 13 , , , cord-015306-us58wwmp 329 14 such such JJ cord-015306-us58wwmp 329 15 as as IN cord-015306-us58wwmp 329 16 late late JJ cord-015306-us58wwmp 329 17 intervention intervention NN cord-015306-us58wwmp 329 18 , , , cord-015306-us58wwmp 329 19 less less RBR cord-015306-us58wwmp 329 20 standardized standardized JJ cord-015306-us58wwmp 329 21 treatment treatment NN cord-015306-us58wwmp 329 22 and and CC cord-015306-us58wwmp 329 23 over over IN cord-015306-us58wwmp 329 24 - - HYPH cord-015306-us58wwmp 329 25 treatment treatment NN cord-015306-us58wwmp 329 26 . . . cord-015306-us58wwmp 330 1 64.36 64.36 CD cord-015306-us58wwmp 330 2 % % NN cord-015306-us58wwmp 330 3 have have VBP cord-015306-us58wwmp 330 4 poor poor JJ cord-015306-us58wwmp 330 5 compliance compliance NN cord-015306-us58wwmp 330 6 with with IN cord-015306-us58wwmp 330 7 doctor doctor NN cord-015306-us58wwmp 330 8 's 's POS cord-015306-us58wwmp 330 9 suggestion suggestion NN cord-015306-us58wwmp 330 10 of of IN cord-015306-us58wwmp 330 11 behaviour behaviour NN cord-015306-us58wwmp 330 12 therapy therapy NN cord-015306-us58wwmp 330 13 and and CC cord-015306-us58wwmp 330 14 alarm alarm NN cord-015306-us58wwmp 330 15 therapy therapy NN cord-015306-us58wwmp 330 16 . . . cord-015306-us58wwmp 331 1 262 262 CD cord-015306-us58wwmp 331 2 children child NNS cord-015306-us58wwmp 331 3 have have VBP cord-015306-us58wwmp 331 4 been be VBN cord-015306-us58wwmp 331 5 suggested suggest VBN cord-015306-us58wwmp 331 6 to to TO cord-015306-us58wwmp 331 7 take take VB cord-015306-us58wwmp 331 8 medicines medicine NNS cord-015306-us58wwmp 331 9 such such JJ cord-015306-us58wwmp 331 10 as as IN cord-015306-us58wwmp 331 11 Chinese chinese JJ cord-015306-us58wwmp 331 12 traditional traditional JJ cord-015306-us58wwmp 331 13 medicine medicine NN cord-015306-us58wwmp 331 14 DDAVP DDAVP NNP cord-015306-us58wwmp 331 15 , , , cord-015306-us58wwmp 331 16 but but CC cord-015306-us58wwmp 331 17 17.8 17.8 CD cord-015306-us58wwmp 331 18 % % NN cord-015306-us58wwmp 331 19 of of IN cord-015306-us58wwmp 331 20 them -PRON- PRP cord-015306-us58wwmp 331 21 refused refuse VBD cord-015306-us58wwmp 331 22 the the DT cord-015306-us58wwmp 331 23 suggestion suggestion NN cord-015306-us58wwmp 331 24 anxious anxious JJ cord-015306-us58wwmp 331 25 of of IN cord-015306-us58wwmp 331 26 the the DT cord-015306-us58wwmp 331 27 side side NN cord-015306-us58wwmp 331 28 effects effect NNS cord-015306-us58wwmp 331 29 or or CC cord-015306-us58wwmp 331 30 stop stop VB cord-015306-us58wwmp 331 31 the the DT cord-015306-us58wwmp 331 32 usage usage NN cord-015306-us58wwmp 331 33 on on IN cord-015306-us58wwmp 331 34 their -PRON- PRP$ cord-015306-us58wwmp 331 35 own own JJ cord-015306-us58wwmp 331 36 . . . cord-015306-us58wwmp 332 1 The the DT cord-015306-us58wwmp 332 2 primary primary JJ cord-015306-us58wwmp 332 3 expected expect VBN cord-015306-us58wwmp 332 4 treatment treatment NN cord-015306-us58wwmp 332 5 goal goal NN cord-015306-us58wwmp 332 6 of of IN cord-015306-us58wwmp 332 7 parents parent NNS cord-015306-us58wwmp 332 8 is be VBZ cord-015306-us58wwmp 332 9 to to TO cord-015306-us58wwmp 332 10 improve improve VB cord-015306-us58wwmp 332 11 the the DT cord-015306-us58wwmp 332 12 symptoms symptom NNS cord-015306-us58wwmp 332 13 , , , cord-015306-us58wwmp 332 14 accounting account VBG cord-015306-us58wwmp 332 15 for for IN cord-015306-us58wwmp 332 16 86.04 86.04 CD cord-015306-us58wwmp 332 17 % % NN cord-015306-us58wwmp 332 18 . . . cord-015306-us58wwmp 333 1 Excluding exclude VBG cord-015306-us58wwmp 333 2 the the DT cord-015306-us58wwmp 333 3 underlying underlie VBG cord-015306-us58wwmp 333 4 diseases disease NNS cord-015306-us58wwmp 333 5 , , , cord-015306-us58wwmp 333 6 Alleviating alleviate VBG cord-015306-us58wwmp 333 7 parents parent NNS cord-015306-us58wwmp 333 8 ' ' POS cord-015306-us58wwmp 333 9 burden burden NN cord-015306-us58wwmp 333 10 , , , cord-015306-us58wwmp 333 11 treating treat VBG cord-015306-us58wwmp 333 12 the the DT cord-015306-us58wwmp 333 13 symptoms symptom NNS cord-015306-us58wwmp 333 14 of of IN cord-015306-us58wwmp 333 15 hyperactivity hyperactivity NN cord-015306-us58wwmp 333 16 or or CC cord-015306-us58wwmp 333 17 inattention inattention NN cord-015306-us58wwmp 333 18 and and CC cord-015306-us58wwmp 333 19 avoiding avoid VBG cord-015306-us58wwmp 333 20 adverse adverse JJ cord-015306-us58wwmp 333 21 effects effect NNS cord-015306-us58wwmp 333 22 on on IN cord-015306-us58wwmp 333 23 intellectual intellectual JJ cord-015306-us58wwmp 333 24 and and CC cord-015306-us58wwmp 333 25 fertility fertility NN cord-015306-us58wwmp 333 26 are be VBP cord-015306-us58wwmp 333 27 also also RB cord-015306-us58wwmp 333 28 included include VBN cord-015306-us58wwmp 333 29 . . . cord-015306-us58wwmp 334 1 For for IN cord-015306-us58wwmp 334 2 children child NNS cord-015306-us58wwmp 334 3 , , , cord-015306-us58wwmp 334 4 they -PRON- PRP cord-015306-us58wwmp 334 5 'd 'd MD cord-015306-us58wwmp 334 6 like like VB cord-015306-us58wwmp 334 7 to to TO cord-015306-us58wwmp 334 8 improve improve VB cord-015306-us58wwmp 334 9 the the DT cord-015306-us58wwmp 334 10 symptoms symptom NNS cord-015306-us58wwmp 334 11 so so IN cord-015306-us58wwmp 334 12 they -PRON- PRP cord-015306-us58wwmp 334 13 wo will MD cord-015306-us58wwmp 334 14 n't not RB cord-015306-us58wwmp 334 15 be be VB cord-015306-us58wwmp 334 16 published publish VBN cord-015306-us58wwmp 334 17 by by IN cord-015306-us58wwmp 334 18 parents parent NNS cord-015306-us58wwmp 334 19 or or CC cord-015306-us58wwmp 334 20 laughed laugh VBN cord-015306-us58wwmp 334 21 by by IN cord-015306-us58wwmp 334 22 their -PRON- PRP$ cord-015306-us58wwmp 334 23 fellows fellow NNS cord-015306-us58wwmp 334 24 . . . cord-015306-us58wwmp 335 1 Most Most JJS cord-015306-us58wwmp 335 2 parents parent NNS cord-015306-us58wwmp 335 3 ( ( -LRB- cord-015306-us58wwmp 335 4 79.94 79.94 CD cord-015306-us58wwmp 335 5 % % NN cord-015306-us58wwmp 335 6 ) ) -RRB- cord-015306-us58wwmp 335 7 preferred prefer VBN cord-015306-us58wwmp 335 8 medicines medicine NNS cord-015306-us58wwmp 335 9 as as IN cord-015306-us58wwmp 335 10 the the DT cord-015306-us58wwmp 335 11 first first JJ cord-015306-us58wwmp 335 12 choice choice NN cord-015306-us58wwmp 335 13 . . . cord-015306-us58wwmp 336 1 12.40 12.40 CD cord-015306-us58wwmp 336 2 % % NN cord-015306-us58wwmp 336 3 parents parent NNS cord-015306-us58wwmp 336 4 and and CC cord-015306-us58wwmp 336 5 children child NNS cord-015306-us58wwmp 336 6 are be VBP cord-015306-us58wwmp 336 7 inconsistent inconsistent JJ cord-015306-us58wwmp 336 8 with with IN cord-015306-us58wwmp 336 9 the the DT cord-015306-us58wwmp 336 10 behavior behavior NN cord-015306-us58wwmp 336 11 therapy therapy NN cord-015306-us58wwmp 336 12 ( ( -LRB- cord-015306-us58wwmp 336 13 the the DT cord-015306-us58wwmp 336 14 rate rate NN cord-015306-us58wwmp 336 15 of of IN cord-015306-us58wwmp 336 16 Newly newly RB cord-015306-us58wwmp 336 17 diagnosed diagnose VBN cord-015306-us58wwmp 336 18 and and CC cord-015306-us58wwmp 336 19 non non JJ cord-015306-us58wwmp 336 20 newly newly RB cord-015306-us58wwmp 336 21 diagnosed diagnose VBN cord-015306-us58wwmp 336 22 children child NNS cord-015306-us58wwmp 336 23 were be VBD cord-015306-us58wwmp 336 24 8.04 8.04 CD cord-015306-us58wwmp 336 25 % % NN cord-015306-us58wwmp 336 26 , , , cord-015306-us58wwmp 336 27 14.03 14.03 CD cord-015306-us58wwmp 336 28 % % NN cord-015306-us58wwmp 336 29 respectly respectly RB cord-015306-us58wwmp 336 30 . . . cord-015306-us58wwmp 337 1 χ χ LS cord-015306-us58wwmp 337 2 2 2 CD cord-015306-us58wwmp 337 3 test test NN cord-015306-us58wwmp 337 4 P>0.05 p>0.05 NN cord-015306-us58wwmp 337 5 ) ) -RRB- cord-015306-us58wwmp 337 6 . . . cord-015306-us58wwmp 338 1 38 38 CD cord-015306-us58wwmp 338 2 ( ( -LRB- cord-015306-us58wwmp 338 3 6.10 6.10 CD cord-015306-us58wwmp 338 4 % % NN cord-015306-us58wwmp 338 5 ) ) -RRB- cord-015306-us58wwmp 338 6 do do VBP cord-015306-us58wwmp 338 7 n't not RB cord-015306-us58wwmp 338 8 accept accept VB cord-015306-us58wwmp 338 9 alarm alarm NN cord-015306-us58wwmp 338 10 therapy therapy NN cord-015306-us58wwmp 338 11 ( ( -LRB- cord-015306-us58wwmp 338 12 the the DT cord-015306-us58wwmp 338 13 rate rate NN cord-015306-us58wwmp 338 14 of of IN cord-015306-us58wwmp 338 15 Newly newly RB cord-015306-us58wwmp 338 16 diagnosed diagnose VBN cord-015306-us58wwmp 338 17 and and CC cord-015306-us58wwmp 338 18 non non JJ cord-015306-us58wwmp 338 19 newly newly RB cord-015306-us58wwmp 338 20 diagnosed diagnose VBN cord-015306-us58wwmp 338 21 children child NNS cord-015306-us58wwmp 338 22 were be VBD cord-015306-us58wwmp 338 23 2.30 2.30 CD cord-015306-us58wwmp 338 24 % % NN cord-015306-us58wwmp 338 25 , , , cord-015306-us58wwmp 338 26 8.02 8.02 CD cord-015306-us58wwmp 338 27 % % NN cord-015306-us58wwmp 338 28 respectly respectly RB cord-015306-us58wwmp 338 29 . . . cord-015306-us58wwmp 339 1 χ χ LS cord-015306-us58wwmp 339 2 2 2 CD cord-015306-us58wwmp 339 3 test test NN cord-015306-us58wwmp 339 4 P>0.05 p>0.05 NN cord-015306-us58wwmp 339 5 ) ) -RRB- cord-015306-us58wwmp 339 6 . . . cord-015306-us58wwmp 340 1 Conclusion conclusion NN cord-015306-us58wwmp 340 2 : : : cord-015306-us58wwmp 340 3 Children child NNS cord-015306-us58wwmp 340 4 with with IN cord-015306-us58wwmp 340 5 primary primary JJ cord-015306-us58wwmp 340 6 enuresis enuresis NN cord-015306-us58wwmp 340 7 need need VBP cord-015306-us58wwmp 340 8 early early JJ cord-015306-us58wwmp 340 9 intervention intervention NN cord-015306-us58wwmp 340 10 and and CC cord-015306-us58wwmp 340 11 standardized standardized JJ cord-015306-us58wwmp 340 12 treatment treatment NN cord-015306-us58wwmp 340 13 . . . cord-015306-us58wwmp 341 1 The the DT cord-015306-us58wwmp 341 2 effect effect NN cord-015306-us58wwmp 341 3 of of IN cord-015306-us58wwmp 341 4 treatment treatment NN cord-015306-us58wwmp 341 5 largely largely RB cord-015306-us58wwmp 341 6 depends depend VBZ cord-015306-us58wwmp 341 7 on on IN cord-015306-us58wwmp 341 8 cooperation cooperation NN cord-015306-us58wwmp 341 9 and and CC cord-015306-us58wwmp 341 10 joint joint JJ cord-015306-us58wwmp 341 11 participation participation NN cord-015306-us58wwmp 341 12 of of IN cord-015306-us58wwmp 341 13 children child NNS cord-015306-us58wwmp 341 14 and and CC cord-015306-us58wwmp 341 15 parents parent NNS cord-015306-us58wwmp 341 16 . . . cord-015306-us58wwmp 342 1 This this DT cord-015306-us58wwmp 342 2 study study NN cord-015306-us58wwmp 342 3 found find VBD cord-015306-us58wwmp 342 4 that that IN cord-015306-us58wwmp 342 5 the the DT cord-015306-us58wwmp 342 6 compliance compliance NN cord-015306-us58wwmp 342 7 of of IN cord-015306-us58wwmp 342 8 behaviour behaviour NN cord-015306-us58wwmp 342 9 training training NN cord-015306-us58wwmp 342 10 and and CC cord-015306-us58wwmp 342 11 alarm alarm NN cord-015306-us58wwmp 342 12 therapy therapy NN cord-015306-us58wwmp 342 13 is be VBZ cord-015306-us58wwmp 342 14 lower low JJR cord-015306-us58wwmp 342 15 than than IN cord-015306-us58wwmp 342 16 medicine medicine NN cord-015306-us58wwmp 342 17 . . . cord-015306-us58wwmp 343 1 The the DT cord-015306-us58wwmp 343 2 goals goal NNS cord-015306-us58wwmp 343 3 of of IN cord-015306-us58wwmp 343 4 children child NNS cord-015306-us58wwmp 343 5 and and CC cord-015306-us58wwmp 343 6 parents parent NNS cord-015306-us58wwmp 343 7 , , , cord-015306-us58wwmp 343 8 living living NN cord-015306-us58wwmp 343 9 conditions condition NNS cord-015306-us58wwmp 343 10 and and CC cord-015306-us58wwmp 343 11 other other JJ cord-015306-us58wwmp 343 12 factors factor NNS cord-015306-us58wwmp 343 13 should should MD cord-015306-us58wwmp 343 14 be be VB cord-015306-us58wwmp 343 15 fully fully RB cord-015306-us58wwmp 343 16 considered consider VBN cord-015306-us58wwmp 343 17 in in IN cord-015306-us58wwmp 343 18 the the DT cord-015306-us58wwmp 343 19 treatment treatment NN cord-015306-us58wwmp 343 20 of of IN cord-015306-us58wwmp 343 21 enuresis enuresis NN cord-015306-us58wwmp 343 22 to to TO cord-015306-us58wwmp 343 23 improve improve VB cord-015306-us58wwmp 343 24 short short JJ cord-015306-us58wwmp 343 25 - - HYPH cord-015306-us58wwmp 343 26 term term NN cord-015306-us58wwmp 343 27 remission remission NN cord-015306-us58wwmp 343 28 rates rate NNS cord-015306-us58wwmp 343 29 and and CC cord-015306-us58wwmp 343 30 long long JJ cord-015306-us58wwmp 343 31 - - HYPH cord-015306-us58wwmp 343 32 term term NN cord-015306-us58wwmp 343 33 cure cure NN cord-015306-us58wwmp 343 34 rate rate NN cord-015306-us58wwmp 343 35 of of IN cord-015306-us58wwmp 343 36 the the DT cord-015306-us58wwmp 343 37 disease disease NN cord-015306-us58wwmp 343 38 . . . cord-015306-us58wwmp 344 1 Beware beware VB cord-015306-us58wwmp 344 2 of of IN cord-015306-us58wwmp 344 3 the the DT cord-015306-us58wwmp 344 4 sleeping sleep VBG cord-015306-us58wwmp 344 5 bladder bladder NN cord-015306-us58wwmp 344 6 in in IN cord-015306-us58wwmp 344 7 monosymptomatic monosymptomatic JJ cord-015306-us58wwmp 344 8 nocturnal nocturnal JJ cord-015306-us58wwmp 344 9 enuresis enuresis NN cord-015306-us58wwmp 344 10 ( ( -LRB- cord-015306-us58wwmp 344 11 MNE MNE NNP cord-015306-us58wwmp 344 12 ) ) -RRB- cord-015306-us58wwmp 344 13 Britt Britt NNP cord-015306-us58wwmp 344 14 Borg Borg NNP cord-015306-us58wwmp 344 15 , , , cord-015306-us58wwmp 344 16 Konstantinos Konstantinos NNP cord-015306-us58wwmp 344 17 Kamperis Kamperis NNP cord-015306-us58wwmp 344 18 , , , cord-015306-us58wwmp 344 19 Birgitte Birgitte NNP cord-015306-us58wwmp 344 20 Mahler Mahler NNP cord-015306-us58wwmp 344 21 , , , cord-015306-us58wwmp 344 22 Soren Soren NNP cord-015306-us58wwmp 344 23 Rittig Rittig NNP cord-015306-us58wwmp 344 24 Pediatrics Pediatrics NNP cord-015306-us58wwmp 344 25 , , , cord-015306-us58wwmp 344 26 Aarhus Aarhus NNP cord-015306-us58wwmp 344 27 University University NNP cord-015306-us58wwmp 344 28 Hospital Hospital NNP cord-015306-us58wwmp 344 29 , , , cord-015306-us58wwmp 344 30 Skejbv Skejbv NNP cord-015306-us58wwmp 344 31 , , , cord-015306-us58wwmp 344 32 Denmark Denmark NNP cord-015306-us58wwmp 344 33 Objective Objective NNP cord-015306-us58wwmp 344 34 : : : cord-015306-us58wwmp 344 35 Bladder bladder NN cord-015306-us58wwmp 344 36 reservoir reservoir NN cord-015306-us58wwmp 344 37 function function NN cord-015306-us58wwmp 344 38 in in IN cord-015306-us58wwmp 344 39 children child NNS cord-015306-us58wwmp 344 40 with with IN cord-015306-us58wwmp 344 41 nocturnal nocturnal JJ cord-015306-us58wwmp 344 42 enuresis enuresis NN cord-015306-us58wwmp 344 43 is be VBZ cord-015306-us58wwmp 344 44 assessed assess VBN cord-015306-us58wwmp 344 45 by by IN cord-015306-us58wwmp 344 46 maximal maximal JJ cord-015306-us58wwmp 344 47 voided void VBN cord-015306-us58wwmp 344 48 volumes volume NNS cord-015306-us58wwmp 344 49 ( ( -LRB- cord-015306-us58wwmp 344 50 MVV MVV NNP cord-015306-us58wwmp 344 51 ) ) -RRB- cord-015306-us58wwmp 344 52 registered register VBN cord-015306-us58wwmp 344 53 on on IN cord-015306-us58wwmp 344 54 frequency frequency NN cord-015306-us58wwmp 344 55 - - HYPH cord-015306-us58wwmp 344 56 volume volume NN cord-015306-us58wwmp 344 57 charts chart NNS cord-015306-us58wwmp 344 58 . . . cord-015306-us58wwmp 345 1 Although although IN cord-015306-us58wwmp 345 2 a a DT cord-015306-us58wwmp 345 3 degree degree NN cord-015306-us58wwmp 345 4 of of IN cord-015306-us58wwmp 345 5 association association NN cord-015306-us58wwmp 345 6 is be VBZ cord-015306-us58wwmp 345 7 evident evident JJ cord-015306-us58wwmp 345 8 , , , cord-015306-us58wwmp 345 9 MVV MVV NNP cord-015306-us58wwmp 345 10 does do VBZ cord-015306-us58wwmp 345 11 not not RB cord-015306-us58wwmp 345 12 always always RB cord-015306-us58wwmp 345 13 reflect reflect VB cord-015306-us58wwmp 345 14 the the DT cord-015306-us58wwmp 345 15 nocturnal nocturnal JJ cord-015306-us58wwmp 345 16 bladder bladder NN cord-015306-us58wwmp 345 17 reservoir reservoir NN cord-015306-us58wwmp 345 18 function function NN cord-015306-us58wwmp 345 19 in in IN cord-015306-us58wwmp 345 20 MNE MNE NNP cord-015306-us58wwmp 345 21 . . . cord-015306-us58wwmp 346 1 We -PRON- PRP cord-015306-us58wwmp 346 2 aimed aim VBD cord-015306-us58wwmp 346 3 to to TO cord-015306-us58wwmp 346 4 evaluate evaluate VB cord-015306-us58wwmp 346 5 the the DT cord-015306-us58wwmp 346 6 nocturnal nocturnal JJ cord-015306-us58wwmp 346 7 bladder bladder NN cord-015306-us58wwmp 346 8 reservoir reservoir NN cord-015306-us58wwmp 346 9 function function NN cord-015306-us58wwmp 346 10 during during IN cord-015306-us58wwmp 346 11 the the DT cord-015306-us58wwmp 346 12 night night NN cord-015306-us58wwmp 346 13 in in IN cord-015306-us58wwmp 346 14 children child NNS cord-015306-us58wwmp 346 15 with with IN cord-015306-us58wwmp 346 16 apparently apparently RB cord-015306-us58wwmp 346 17 normal normal JJ cord-015306-us58wwmp 346 18 MVV MVV NNP cord-015306-us58wwmp 346 19 . . . cord-015306-us58wwmp 347 1 Methods method NNS cord-015306-us58wwmp 347 2 : : : cord-015306-us58wwmp 348 1 Data datum NNS cord-015306-us58wwmp 348 2 from from IN cord-015306-us58wwmp 348 3 557 557 CD cord-015306-us58wwmp 348 4 children child NNS cord-015306-us58wwmp 348 5 aged age VBN cord-015306-us58wwmp 348 6 5 5 CD cord-015306-us58wwmp 348 7 - - SYM cord-015306-us58wwmp 348 8 15 15 CD cord-015306-us58wwmp 348 9 treated treat VBN cord-015306-us58wwmp 348 10 for for IN cord-015306-us58wwmp 348 11 MNE MNE NNP cord-015306-us58wwmp 348 12 in in IN cord-015306-us58wwmp 348 13 a a DT cord-015306-us58wwmp 348 14 tertiary tertiary JJ cord-015306-us58wwmp 348 15 referral referral NN cord-015306-us58wwmp 348 16 centre centre NN cord-015306-us58wwmp 348 17 was be VBD cord-015306-us58wwmp 348 18 analyzed analyze VBN cord-015306-us58wwmp 348 19 . . . cord-015306-us58wwmp 349 1 Data datum NNS cord-015306-us58wwmp 349 2 from from IN cord-015306-us58wwmp 349 3 135 135 CD cord-015306-us58wwmp 349 4 children child NNS cord-015306-us58wwmp 349 5 was be VBD cord-015306-us58wwmp 349 6 excluded exclude VBN cord-015306-us58wwmp 349 7 due due IN cord-015306-us58wwmp 349 8 to to IN cord-015306-us58wwmp 349 9 reduced reduce VBN cord-015306-us58wwmp 349 10 MVV MVV NNP cord-015306-us58wwmp 349 11 according accord VBG cord-015306-us58wwmp 349 12 to to IN cord-015306-us58wwmp 349 13 ICCS ICCS NNP cord-015306-us58wwmp 349 14 standardization standardization NN cord-015306-us58wwmp 349 15 and and CC cord-015306-us58wwmp 349 16 156 156 CD cord-015306-us58wwmp 349 17 due due IN cord-015306-us58wwmp 349 18 to to IN cord-015306-us58wwmp 349 19 lack lack NN cord-015306-us58wwmp 349 20 of of IN cord-015306-us58wwmp 349 21 home home NN cord-015306-us58wwmp 349 22 recordings recording NNS cord-015306-us58wwmp 349 23 . . . cord-015306-us58wwmp 350 1 The the DT cord-015306-us58wwmp 350 2 remaining remain VBG cord-015306-us58wwmp 350 3 were be VBD cord-015306-us58wwmp 350 4 divided divide VBN cord-015306-us58wwmp 350 5 into into IN cord-015306-us58wwmp 350 6 two two CD cord-015306-us58wwmp 350 7 groups group NNS cord-015306-us58wwmp 350 8 , , , cord-015306-us58wwmp 350 9 based base VBN cord-015306-us58wwmp 350 10 on on IN cord-015306-us58wwmp 350 11 whether whether IN cord-015306-us58wwmp 350 12 MVV MVV NNP cord-015306-us58wwmp 350 13 was be VBD cord-015306-us58wwmp 350 14 above above JJ cord-015306-us58wwmp 350 15 ( ( -LRB- cord-015306-us58wwmp 350 16 n=91 n=91 NNP cord-015306-us58wwmp 350 17 ) ) -RRB- cord-015306-us58wwmp 350 18 or or CC cord-015306-us58wwmp 350 19 below below IN cord-015306-us58wwmp 350 20 ( ( -LRB- cord-015306-us58wwmp 350 21 n=175 n=175 RB cord-015306-us58wwmp 350 22 ) ) -RRB- cord-015306-us58wwmp 350 23 the the DT cord-015306-us58wwmp 350 24 average average JJ cord-015306-us58wwmp 350 25 nocturnal nocturnal JJ cord-015306-us58wwmp 350 26 urine urine NN cord-015306-us58wwmp 350 27 production production NN cord-015306-us58wwmp 350 28 during during IN cord-015306-us58wwmp 350 29 wet wet JJ cord-015306-us58wwmp 350 30 nights night NNS cord-015306-us58wwmp 350 31 ( ( -LRB- cord-015306-us58wwmp 350 32 NUPw NUPw NNS cord-015306-us58wwmp 350 33 ) ) -RRB- cord-015306-us58wwmp 350 34 . . . cord-015306-us58wwmp 351 1 First first JJ cord-015306-us58wwmp 351 2 morning morning NN cord-015306-us58wwmp 351 3 voids void NNS cord-015306-us58wwmp 351 4 were be VBD cord-015306-us58wwmp 351 5 not not RB cord-015306-us58wwmp 351 6 included include VBN cord-015306-us58wwmp 351 7 in in IN cord-015306-us58wwmp 351 8 MVV MVV NNP cord-015306-us58wwmp 351 9 values value NNS cord-015306-us58wwmp 351 10 . . . cord-015306-us58wwmp 352 1 Results result NNS cord-015306-us58wwmp 352 2 : : : cord-015306-us58wwmp 353 1 34 34 CD cord-015306-us58wwmp 353 2 % % NN cord-015306-us58wwmp 353 3 of of IN cord-015306-us58wwmp 353 4 the the DT cord-015306-us58wwmp 353 5 children child NNS cord-015306-us58wwmp 353 6 with with IN cord-015306-us58wwmp 353 7 MNE MNE NNP cord-015306-us58wwmp 353 8 and and CC cord-015306-us58wwmp 353 9 a a DT cord-015306-us58wwmp 353 10 normal normal JJ cord-015306-us58wwmp 353 11 bladder bladder NN cord-015306-us58wwmp 353 12 capacity capacity NN cord-015306-us58wwmp 353 13 had have VBD cord-015306-us58wwmp 353 14 an an DT cord-015306-us58wwmp 353 15 average average JJ cord-015306-us58wwmp 353 16 nocturnal nocturnal JJ cord-015306-us58wwmp 353 17 urine urine NN cord-015306-us58wwmp 353 18 production production NN cord-015306-us58wwmp 353 19 during during IN cord-015306-us58wwmp 353 20 wet wet JJ cord-015306-us58wwmp 353 21 nights night NNS cord-015306-us58wwmp 353 22 below below IN cord-015306-us58wwmp 353 23 their -PRON- PRP$ cord-015306-us58wwmp 353 24 MVV MVV NNP cord-015306-us58wwmp 353 25 , , , cord-015306-us58wwmp 353 26 one one CD cord-015306-us58wwmp 353 27 third third NN cord-015306-us58wwmp 353 28 of of IN cord-015306-us58wwmp 353 29 these these DT cord-015306-us58wwmp 353 30 had have VBD cord-015306-us58wwmp 353 31 NUPw NUPw NNS cord-015306-us58wwmp 353 32 below below IN cord-015306-us58wwmp 353 33 65 65 CD cord-015306-us58wwmp 353 34 % % NN cord-015306-us58wwmp 353 35 of of IN cord-015306-us58wwmp 353 36 MVV MVV NNP cord-015306-us58wwmp 353 37 expected expect VBN cord-015306-us58wwmp 353 38 for for IN cord-015306-us58wwmp 353 39 age age NN cord-015306-us58wwmp 353 40 . . . cord-015306-us58wwmp 354 1 These these DT cord-015306-us58wwmp 354 2 children child NNS cord-015306-us58wwmp 354 3 did do VBD cord-015306-us58wwmp 354 4 not not RB cord-015306-us58wwmp 354 5 differ differ VB cord-015306-us58wwmp 354 6 significantly significantly RB cord-015306-us58wwmp 354 7 in in IN cord-015306-us58wwmp 354 8 terms term NNS cord-015306-us58wwmp 354 9 of of IN cord-015306-us58wwmp 354 10 demographic demographic JJ cord-015306-us58wwmp 354 11 characteristics characteristic NNS cord-015306-us58wwmp 354 12 , , , cord-015306-us58wwmp 354 13 frequency frequency NN cord-015306-us58wwmp 354 14 of of IN cord-015306-us58wwmp 354 15 wet wet JJ cord-015306-us58wwmp 354 16 nights night NNS cord-015306-us58wwmp 354 17 or or CC cord-015306-us58wwmp 354 18 treatment treatment NN cord-015306-us58wwmp 354 19 time time NN cord-015306-us58wwmp 354 20 needed need VBN cord-015306-us58wwmp 354 21 to to TO cord-015306-us58wwmp 354 22 achieve achieve VB cord-015306-us58wwmp 354 23 dryness dryness NN cord-015306-us58wwmp 354 24 . . . cord-015306-us58wwmp 355 1 Urine urine NN cord-015306-us58wwmp 355 2 output output NN cord-015306-us58wwmp 355 3 during during IN cord-015306-us58wwmp 355 4 dry dry JJ cord-015306-us58wwmp 355 5 nights night NNS cord-015306-us58wwmp 355 6 was be VBD cord-015306-us58wwmp 355 7 not not RB cord-015306-us58wwmp 355 8 statistical statistical JJ cord-015306-us58wwmp 355 9 significant significant JJ cord-015306-us58wwmp 355 10 between between IN cord-015306-us58wwmp 355 11 the the DT cord-015306-us58wwmp 355 12 groups group NNS cord-015306-us58wwmp 355 13 ( ( -LRB- cord-015306-us58wwmp 355 14 p=0.077 p=0.077 NNP cord-015306-us58wwmp 355 15 , , , cord-015306-us58wwmp 355 16 mean mean JJ cord-015306-us58wwmp 355 17 diff.=28.47 diff.=28.47 NNP cord-015306-us58wwmp 355 18 ml ml NNP cord-015306-us58wwmp 355 19 ) ) -RRB- cord-015306-us58wwmp 355 20 . . . cord-015306-us58wwmp 356 1 The the DT cord-015306-us58wwmp 356 2 group group NN cord-015306-us58wwmp 356 3 with with IN cord-015306-us58wwmp 356 4 MVV MVV NNP cord-015306-us58wwmp 357 1 > > XX cord-015306-us58wwmp 358 1 NUPwet nupwet CD cord-015306-us58wwmp 358 2 shared share VBD cord-015306-us58wwmp 358 3 significantly significantly RB cord-015306-us58wwmp 358 4 higher high JJR cord-015306-us58wwmp 358 5 MVV MVV NNP cord-015306-us58wwmp 358 6 to to IN cord-015306-us58wwmp 358 7 MVV MVV NNP cord-015306-us58wwmp 358 8 expected expect VBN cord-015306-us58wwmp 358 9 for for IN cord-015306-us58wwmp 358 10 age age NN cord-015306-us58wwmp 358 11 ratios ratio NNS cord-015306-us58wwmp 358 12 ( ( -LRB- cord-015306-us58wwmp 358 13 mean mean UH cord-015306-us58wwmp 358 14 diff=0.16 diff=0.16 NNP cord-015306-us58wwmp 358 15 , , , cord-015306-us58wwmp 358 16 p<0.05 p<0.05 CD cord-015306-us58wwmp 358 17 ) ) -RRB- cord-015306-us58wwmp 358 18 . . . cord-015306-us58wwmp 359 1 Urine urine NN cord-015306-us58wwmp 359 2 output output NN cord-015306-us58wwmp 359 3 during during IN cord-015306-us58wwmp 359 4 wet wet JJ cord-015306-us58wwmp 359 5 nights night NNS cord-015306-us58wwmp 359 6 was be VBD cord-015306-us58wwmp 359 7 lower low JJR cord-015306-us58wwmp 359 8 in in IN cord-015306-us58wwmp 359 9 the the DT cord-015306-us58wwmp 359 10 group group NN cord-015306-us58wwmp 359 11 of of IN cord-015306-us58wwmp 359 12 children child NNS cord-015306-us58wwmp 359 13 with with IN cord-015306-us58wwmp 359 14 MVV MVV NNP cord-015306-us58wwmp 360 1 > > XX cord-015306-us58wwmp 361 1 NUPw NUPw NNPS cord-015306-us58wwmp 361 2 ( ( -LRB- cord-015306-us58wwmp 361 3 diff diff NNP cord-015306-us58wwmp 361 4 : : : cord-015306-us58wwmp 361 5 96.45 96.45 CD cord-015306-us58wwmp 361 6 ml ml NNS cord-015306-us58wwmp 361 7 , , , cord-015306-us58wwmp 361 8 p<0.05 p<0.05 CD cord-015306-us58wwmp 361 9 ) ) -RRB- cord-015306-us58wwmp 361 10 . . . cord-015306-us58wwmp 362 1 Conclusion conclusion NN cord-015306-us58wwmp 362 2 : : : cord-015306-us58wwmp 362 3 Children child NNS cord-015306-us58wwmp 362 4 with with IN cord-015306-us58wwmp 362 5 MNE MNE NNP cord-015306-us58wwmp 362 6 and and CC cord-015306-us58wwmp 362 7 apparently apparently RB cord-015306-us58wwmp 362 8 normal normal JJ cord-015306-us58wwmp 362 9 bladder bladder NN cord-015306-us58wwmp 362 10 reservoir reservoir NN cord-015306-us58wwmp 362 11 function function NN cord-015306-us58wwmp 362 12 during during IN cord-015306-us58wwmp 362 13 daytime daytime NN cord-015306-us58wwmp 362 14 may may MD cord-015306-us58wwmp 362 15 experience experience VB cord-015306-us58wwmp 362 16 wet wet JJ cord-015306-us58wwmp 362 17 nights night NNS cord-015306-us58wwmp 362 18 with with IN cord-015306-us58wwmp 362 19 urine urine NN cord-015306-us58wwmp 362 20 volumes volume NNS cord-015306-us58wwmp 362 21 well well RB cord-015306-us58wwmp 362 22 below below IN cord-015306-us58wwmp 362 23 their -PRON- PRP$ cord-015306-us58wwmp 362 24 MVV MVV NNP cord-015306-us58wwmp 362 25 and and CC cord-015306-us58wwmp 362 26 MVV MVV NNP cord-015306-us58wwmp 362 27 expected expect VBD cord-015306-us58wwmp 362 28 for for IN cord-015306-us58wwmp 362 29 age age NN cord-015306-us58wwmp 362 30 . . . cord-015306-us58wwmp 363 1 The the DT cord-015306-us58wwmp 363 2 fact fact NN cord-015306-us58wwmp 363 3 indicates indicate VBZ cord-015306-us58wwmp 363 4 bladder bladder NN cord-015306-us58wwmp 363 5 reservoir reservoir NN cord-015306-us58wwmp 363 6 function function NN cord-015306-us58wwmp 363 7 abnormalities abnormality NNS cord-015306-us58wwmp 363 8 during during IN cord-015306-us58wwmp 363 9 sleep sleep NN cord-015306-us58wwmp 363 10 that that WDT cord-015306-us58wwmp 363 11 is be VBZ cord-015306-us58wwmp 363 12 not not RB cord-015306-us58wwmp 363 13 assessed assess VBN cord-015306-us58wwmp 363 14 by by IN cord-015306-us58wwmp 363 15 day day NN cord-015306-us58wwmp 363 16 recordings recording NNS cord-015306-us58wwmp 363 17 . . . cord-015306-us58wwmp 364 1 Physicians physician NNS cord-015306-us58wwmp 364 2 treating treat VBG cord-015306-us58wwmp 364 3 children child NNS cord-015306-us58wwmp 364 4 with with IN cord-015306-us58wwmp 364 5 MNE MNE NNP cord-015306-us58wwmp 364 6 should should MD cord-015306-us58wwmp 364 7 consider consider VB cord-015306-us58wwmp 364 8 anticholinergic anticholinergic JJ cord-015306-us58wwmp 364 9 treatment treatment NN cord-015306-us58wwmp 364 10 . . . cord-015306-us58wwmp 365 1 One one CD cord-015306-us58wwmp 365 2 year year NN cord-015306-us58wwmp 365 3 experience experience NN cord-015306-us58wwmp 365 4 of of IN cord-015306-us58wwmp 365 5 a a DT cord-015306-us58wwmp 365 6 multidisciplinary multidisciplinary JJ cord-015306-us58wwmp 365 7 investigation investigation NN cord-015306-us58wwmp 365 8 on on IN cord-015306-us58wwmp 365 9 Nocturnal Nocturnal NNP cord-015306-us58wwmp 365 10 Enuresis Enuresis NNP cord-015306-us58wwmp 365 11 in in IN cord-015306-us58wwmp 365 12 a a DT cord-015306-us58wwmp 365 13 Brazilian Brazilian NNP cord-015306-us58wwmp 365 14 Tertiary Tertiary NNP cord-015306-us58wwmp 365 15 Care Care NNP cord-015306-us58wwmp 365 16 Facility Facility NNP cord-015306-us58wwmp 365 17 Objective objective NN cord-015306-us58wwmp 365 18 : : : cord-015306-us58wwmp 366 1 To to TO cord-015306-us58wwmp 366 2 characterize characterize VB cord-015306-us58wwmp 366 3 a a DT cord-015306-us58wwmp 366 4 cohort cohort NN cord-015306-us58wwmp 366 5 of of IN cord-015306-us58wwmp 366 6 children child NNS cord-015306-us58wwmp 366 7 , , , cord-015306-us58wwmp 366 8 6 6 CD cord-015306-us58wwmp 366 9 - - SYM cord-015306-us58wwmp 366 10 16 16 CD cord-015306-us58wwmp 366 11 yrs yr NNS cord-015306-us58wwmp 366 12 old old JJ cord-015306-us58wwmp 366 13 , , , cord-015306-us58wwmp 366 14 with with IN cord-015306-us58wwmp 366 15 nocturnal nocturnal JJ cord-015306-us58wwmp 366 16 enuresis enuresis NN cord-015306-us58wwmp 366 17 , , , cord-015306-us58wwmp 366 18 defined define VBN cord-015306-us58wwmp 366 19 by by IN cord-015306-us58wwmp 366 20 2010 2010 CD cord-015306-us58wwmp 366 21 ICCS iccs JJ cord-015306-us58wwmp 366 22 criteria criterion NNS cord-015306-us58wwmp 366 23 on on IN cord-015306-us58wwmp 366 24 the the DT cord-015306-us58wwmp 366 25 basis basis NN cord-015306-us58wwmp 366 26 of of IN cord-015306-us58wwmp 366 27 a a DT cord-015306-us58wwmp 366 28 multidisciplinary multidisciplinary JJ cord-015306-us58wwmp 366 29 evaluation evaluation NN cord-015306-us58wwmp 366 30 including include VBG cord-015306-us58wwmp 366 31 renal renal JJ cord-015306-us58wwmp 366 32 , , , cord-015306-us58wwmp 366 33 neurological neurological JJ cord-015306-us58wwmp 366 34 , , , cord-015306-us58wwmp 366 35 psychological psychological JJ cord-015306-us58wwmp 366 36 and and CC cord-015306-us58wwmp 366 37 physical physical JJ cord-015306-us58wwmp 366 38 therapy therapy NN cord-015306-us58wwmp 366 39 approaches approach NNS cord-015306-us58wwmp 366 40 . . . cord-015306-us58wwmp 367 1 Chronic chronic JJ cord-015306-us58wwmp 367 2 clinical clinical JJ cord-015306-us58wwmp 367 3 conditions condition NNS cord-015306-us58wwmp 367 4 and and CC cord-015306-us58wwmp 367 5 genetic genetic JJ cord-015306-us58wwmp 367 6 disorders disorder NNS cord-015306-us58wwmp 367 7 constituted constitute VBD cord-015306-us58wwmp 367 8 exclusion exclusion NN cord-015306-us58wwmp 367 9 criteria criterion NNS cord-015306-us58wwmp 367 10 . . . cord-015306-us58wwmp 368 1 Methods method NNS cord-015306-us58wwmp 368 2 : : : cord-015306-us58wwmp 368 3 After after IN cord-015306-us58wwmp 368 4 IRB IRB NNP cord-015306-us58wwmp 368 5 approval approval NN cord-015306-us58wwmp 368 6 , , , cord-015306-us58wwmp 368 7 families family NNS cord-015306-us58wwmp 368 8 were be VBD cord-015306-us58wwmp 368 9 invited invite VBN cord-015306-us58wwmp 368 10 to to TO cord-015306-us58wwmp 368 11 participate participate VB cord-015306-us58wwmp 368 12 in in IN cord-015306-us58wwmp 368 13 the the DT cord-015306-us58wwmp 368 14 project project NN cord-015306-us58wwmp 368 15 through through IN cord-015306-us58wwmp 368 16 press press NN cord-015306-us58wwmp 368 17 releases release NNS cord-015306-us58wwmp 368 18 , , , cord-015306-us58wwmp 368 19 130 130 CD cord-015306-us58wwmp 368 20 children child NNS cord-015306-us58wwmp 368 21 completed complete VBD cord-015306-us58wwmp 368 22 quality quality NN cord-015306-us58wwmp 368 23 of of IN cord-015306-us58wwmp 368 24 life life NN cord-015306-us58wwmp 368 25 evaluation evaluation NN cord-015306-us58wwmp 368 26 through through IN cord-015306-us58wwmp 368 27 clinically clinically RB cord-015306-us58wwmp 368 28 validated validate VBN cord-015306-us58wwmp 368 29 questionnaires questionnaire NNS cord-015306-us58wwmp 368 30 , , , cord-015306-us58wwmp 368 31 followed follow VBN cord-015306-us58wwmp 368 32 by by IN cord-015306-us58wwmp 368 33 a a DT cord-015306-us58wwmp 368 34 one one CD cord-015306-us58wwmp 368 35 -day -day DT cord-015306-us58wwmp 368 36 multidisciplinary multidisciplinary JJ cord-015306-us58wwmp 368 37 clinical clinical JJ cord-015306-us58wwmp 368 38 evaluation evaluation NN cord-015306-us58wwmp 368 39 . . . cord-015306-us58wwmp 369 1 Sleep sleep NN cord-015306-us58wwmp 369 2 , , , cord-015306-us58wwmp 369 3 urinary urinary JJ cord-015306-us58wwmp 369 4 and and CC cord-015306-us58wwmp 369 5 intestinal intestinal JJ cord-015306-us58wwmp 369 6 diaries diary NNS cord-015306-us58wwmp 369 7 were be VBD cord-015306-us58wwmp 369 8 evaluated evaluate VBN cord-015306-us58wwmp 369 9 . . . cord-015306-us58wwmp 370 1 Urinary urinary JJ cord-015306-us58wwmp 370 2 sonography sonography NN cord-015306-us58wwmp 370 3 , , , cord-015306-us58wwmp 370 4 nocturnal nocturnal JJ cord-015306-us58wwmp 370 5 polysomnography polysomnography NN cord-015306-us58wwmp 370 6 , , , cord-015306-us58wwmp 370 7 urinary urinary JJ cord-015306-us58wwmp 370 8 and and CC cord-015306-us58wwmp 370 9 blood blood NN cord-015306-us58wwmp 370 10 analysis analysis NN cord-015306-us58wwmp 370 11 were be VBD cord-015306-us58wwmp 370 12 scheduled schedule VBN cord-015306-us58wwmp 370 13 . . . cord-015306-us58wwmp 371 1 Results result NNS cord-015306-us58wwmp 371 2 : : : cord-015306-us58wwmp 371 3 96/130 96/130 CD cord-015306-us58wwmp 371 4 participants participant NNS cord-015306-us58wwmp 371 5 ( ( -LRB- cord-015306-us58wwmp 371 6 pts)were pts)were JJ cord-015306-us58wwmp 371 7 male male NN cord-015306-us58wwmp 371 8 ( ( -LRB- cord-015306-us58wwmp 371 9 73,8 73,8 CD cord-015306-us58wwmp 371 10 % % NN cord-015306-us58wwmp 371 11 ) ) -RRB- cord-015306-us58wwmp 371 12 , , , cord-015306-us58wwmp 371 13 mean mean VBP cord-015306-us58wwmp 371 14 age age NN cord-015306-us58wwmp 371 15 8 8 CD cord-015306-us58wwmp 371 16 ±1 ±1 NNP cord-015306-us58wwmp 371 17 yrs yrs NN cord-015306-us58wwmp 371 18 . . . cord-015306-us58wwmp 372 1 Twenty twenty CD cord-015306-us58wwmp 372 2 two two CD cord-015306-us58wwmp 372 3 children child NNS cord-015306-us58wwmp 372 4 were be VBD cord-015306-us58wwmp 372 5 excluded exclude VBN cord-015306-us58wwmp 372 6 due due IN cord-015306-us58wwmp 372 7 to to IN cord-015306-us58wwmp 372 8 noncompliance noncompliance NN cord-015306-us58wwmp 372 9 /chronic /chronic . cord-015306-us58wwmp 372 10 clinical clinical JJ cord-015306-us58wwmp 372 11 conditions condition NNS cord-015306-us58wwmp 372 12 . . . cord-015306-us58wwmp 373 1 118/130 118/130 LS cord-015306-us58wwmp 373 2 pts pt NNS cord-015306-us58wwmp 373 3 were be VBD cord-015306-us58wwmp 373 4 evaluated evaluate VBN cord-015306-us58wwmp 373 5 . . . cord-015306-us58wwmp 374 1 93/130 93/130 CD cord-015306-us58wwmp 374 2 parents parent NNS cord-015306-us58wwmp 374 3 of of IN cord-015306-us58wwmp 374 4 children child NNS cord-015306-us58wwmp 374 5 / / SYM cord-015306-us58wwmp 374 6 adolescents adolescent NNS cord-015306-us58wwmp 374 7 , , , cord-015306-us58wwmp 374 8 answered answer VBD cord-015306-us58wwmp 374 9 the the DT cord-015306-us58wwmp 374 10 CBCL CBCL NNP cord-015306-us58wwmp 374 11 questionnaire questionnaire NN cord-015306-us58wwmp 374 12 , , , cord-015306-us58wwmp 374 13 25/93 25/93 CD cord-015306-us58wwmp 374 14 ( ( -LRB- cord-015306-us58wwmp 374 15 27 27 CD cord-015306-us58wwmp 374 16 % % NN cord-015306-us58wwmp 374 17 ) ) -RRB- cord-015306-us58wwmp 374 18 of of IN cord-015306-us58wwmp 374 19 which which WDT cord-015306-us58wwmp 374 20 resulted result VBD cord-015306-us58wwmp 374 21 in in IN cord-015306-us58wwmp 374 22 scores score NNS cord-015306-us58wwmp 374 23 compatible compatible JJ cord-015306-us58wwmp 374 24 with with IN cord-015306-us58wwmp 374 25 clinical clinical JJ cord-015306-us58wwmp 374 26 psychological psychological JJ cord-015306-us58wwmp 374 27 conditions condition NNS cord-015306-us58wwmp 374 28 . . . cord-015306-us58wwmp 375 1 Monosymptomatic monosymptomatic JJ cord-015306-us58wwmp 375 2 enuresis enuresis NN cord-015306-us58wwmp 375 3 ( ( -LRB- cord-015306-us58wwmp 375 4 MoE MoE NNP cord-015306-us58wwmp 375 5 ) ) -RRB- cord-015306-us58wwmp 375 6 was be VBD cord-015306-us58wwmp 375 7 diagnosed diagnose VBN cord-015306-us58wwmp 375 8 in in IN cord-015306-us58wwmp 375 9 89/118 89/118 CD cord-015306-us58wwmp 375 10 children child NNS cord-015306-us58wwmp 375 11 ( ( -LRB- cord-015306-us58wwmp 375 12 75.4 75.4 CD cord-015306-us58wwmp 375 13 % % NN cord-015306-us58wwmp 375 14 ) ) -RRB- cord-015306-us58wwmp 375 15 . . . cord-015306-us58wwmp 376 1 In in IN cord-015306-us58wwmp 376 2 the the DT cord-015306-us58wwmp 376 3 MoE MoE NNP cord-015306-us58wwmp 376 4 group group NNP cord-015306-us58wwmp 376 5 , , , cord-015306-us58wwmp 376 6 67/89 67/89 CD cord-015306-us58wwmp 376 7 pts pt NNS cord-015306-us58wwmp 376 8 were be VBD cord-015306-us58wwmp 376 9 diagnosed diagnose VBN cord-015306-us58wwmp 376 10 with with IN cord-015306-us58wwmp 376 11 intestinal intestinal JJ cord-015306-us58wwmp 376 12 constipation constipation NN cord-015306-us58wwmp 376 13 ; ; : cord-015306-us58wwmp 376 14 7/89 7/89 CD cord-015306-us58wwmp 376 15 pts pts NN cord-015306-us58wwmp 376 16 with with IN cord-015306-us58wwmp 376 17 obstructive obstructive JJ cord-015306-us58wwmp 376 18 sleep sleep NN cord-015306-us58wwmp 376 19 apnea apnea NN cord-015306-us58wwmp 376 20 , , , cord-015306-us58wwmp 376 21 2/89 2/89 CD cord-015306-us58wwmp 376 22 pts pts NN cord-015306-us58wwmp 376 23 with with IN cord-015306-us58wwmp 376 24 hipercalciuria hipercalciuria NNP cord-015306-us58wwmp 376 25 and and CC cord-015306-us58wwmp 376 26 2/89 2/89 CD cord-015306-us58wwmp 376 27 were be VBD cord-015306-us58wwmp 376 28 characterized characterize VBN cord-015306-us58wwmp 376 29 with with IN cord-015306-us58wwmp 376 30 ADHD ADHD NNP cord-015306-us58wwmp 376 31 . . . cord-015306-us58wwmp 377 1 Area area NN cord-015306-us58wwmp 377 2 and and CC cord-015306-us58wwmp 377 3 velocity velocity NN cord-015306-us58wwmp 377 4 of of IN cord-015306-us58wwmp 377 5 center center NN cord-015306-us58wwmp 377 6 or or CC cord-015306-us58wwmp 377 7 pressure pressure NN cord-015306-us58wwmp 377 8 displacement displacement NN cord-015306-us58wwmp 377 9 ( ( -LRB- cord-015306-us58wwmp 377 10 VM VM NNP cord-015306-us58wwmp 377 11 ) ) -RRB- cord-015306-us58wwmp 377 12 were be VBD cord-015306-us58wwmp 377 13 used use VBN cord-015306-us58wwmp 377 14 for for IN cord-015306-us58wwmp 377 15 postural postural JJ cord-015306-us58wwmp 377 16 control control NN cord-015306-us58wwmp 377 17 evaluation evaluation NN cord-015306-us58wwmp 377 18 and and CC cord-015306-us58wwmp 377 19 resulted result VBD cord-015306-us58wwmp 377 20 in in IN cord-015306-us58wwmp 377 21 3,67 3,67 NNP cord-015306-us58wwmp 377 22 ±2,95 ±2,95 NNP cord-015306-us58wwmp 377 23 cm cm NN cord-015306-us58wwmp 377 24 2 2 CD cord-015306-us58wwmp 377 25 and and CC cord-015306-us58wwmp 377 26 20,35±13,04 20,35±13,04 CD cord-015306-us58wwmp 377 27 cm.s-1 cm.s-1 CD cord-015306-us58wwmp 377 28 , , , cord-015306-us58wwmp 377 29 respectively respectively RB cord-015306-us58wwmp 377 30 ; ; : cord-015306-us58wwmp 377 31 22/89 22/89 CD cord-015306-us58wwmp 377 32 pts pt NNS cord-015306-us58wwmp 377 33 were be VBD cord-015306-us58wwmp 377 34 also also RB cord-015306-us58wwmp 377 35 assessed assess VBN cord-015306-us58wwmp 377 36 for for IN cord-015306-us58wwmp 377 37 postural postural JJ cord-015306-us58wwmp 377 38 alignment alignment NN cord-015306-us58wwmp 377 39 exhibiting exhibit VBG cord-015306-us58wwmp 377 40 pelvic pelvic JJ cord-015306-us58wwmp 377 41 anteversion anteversion NN cord-015306-us58wwmp 377 42 ( ( -LRB- cord-015306-us58wwmp 377 43 10,27 10,27 CD cord-015306-us58wwmp 377 44 ±3,71 ±3,71 NNP cord-015306-us58wwmp 377 45 grades grade NNS cord-015306-us58wwmp 377 46 ) ) -RRB- cord-015306-us58wwmp 377 47 and and CC cord-015306-us58wwmp 377 48 head head NN cord-015306-us58wwmp 377 49 protusion protusion NN cord-015306-us58wwmp 377 50 ( ( -LRB- cord-015306-us58wwmp 377 51 0,40±1,86 0,40±1,86 CD cord-015306-us58wwmp 377 52 grades grade NNS cord-015306-us58wwmp 377 53 ) ) -RRB- cord-015306-us58wwmp 377 54 . . . cord-015306-us58wwmp 378 1 These these DT cord-015306-us58wwmp 378 2 results result NNS cord-015306-us58wwmp 378 3 corroborate corroborate VBP cord-015306-us58wwmp 378 4 with with IN cord-015306-us58wwmp 378 5 a a DT cord-015306-us58wwmp 378 6 smaller small JJR cord-015306-us58wwmp 378 7 range range NN cord-015306-us58wwmp 378 8 of of IN cord-015306-us58wwmp 378 9 motion motion NN cord-015306-us58wwmp 378 10 found find VBN cord-015306-us58wwmp 378 11 for for IN cord-015306-us58wwmp 378 12 hip hip NN cord-015306-us58wwmp 378 13 flexion flexion NN cord-015306-us58wwmp 378 14 ( ( -LRB- cord-015306-us58wwmp 378 15 94,86±17,14 94,86±17,14 CD cord-015306-us58wwmp 378 16 grades grade NNS cord-015306-us58wwmp 378 17 ) ) -RRB- cord-015306-us58wwmp 378 18 and and CC cord-015306-us58wwmp 378 19 hip hip NN cord-015306-us58wwmp 378 20 extension extension NN cord-015306-us58wwmp 378 21 ( ( -LRB- cord-015306-us58wwmp 378 22 2±3,89 2±3,89 CD cord-015306-us58wwmp 378 23 grades grade NNS cord-015306-us58wwmp 378 24 ) ) -RRB- cord-015306-us58wwmp 378 25 assessed assess VBD cord-015306-us58wwmp 378 26 using use VBG cord-015306-us58wwmp 378 27 a a DT cord-015306-us58wwmp 378 28 goniometer goniometer NN cord-015306-us58wwmp 378 29 . . . cord-015306-us58wwmp 379 1 Conclusion conclusion NN cord-015306-us58wwmp 379 2 : : : cord-015306-us58wwmp 380 1 Multidisciplinary multidisciplinary JJ cord-015306-us58wwmp 380 2 evaluation evaluation NN cord-015306-us58wwmp 380 3 of of IN cord-015306-us58wwmp 380 4 enuretic enuretic JJ cord-015306-us58wwmp 380 5 children child NNS cord-015306-us58wwmp 380 6 may may MD cord-015306-us58wwmp 380 7 be be VB cord-015306-us58wwmp 380 8 the the DT cord-015306-us58wwmp 380 9 key key NN cord-015306-us58wwmp 380 10 to to TO cord-015306-us58wwmp 380 11 optimize optimize VB cord-015306-us58wwmp 380 12 therapy therapy NN cord-015306-us58wwmp 380 13 on on IN cord-015306-us58wwmp 380 14 the the DT cord-015306-us58wwmp 380 15 basis basis NN cord-015306-us58wwmp 380 16 of of IN cord-015306-us58wwmp 380 17 the the DT cord-015306-us58wwmp 380 18 underlying underlie VBG cord-015306-us58wwmp 380 19 etiology etiology NN cord-015306-us58wwmp 380 20 of of IN cord-015306-us58wwmp 380 21 the the DT cord-015306-us58wwmp 380 22 process process NN cord-015306-us58wwmp 380 23 Abstract Abstract NNP cord-015306-us58wwmp 381 1 # # $ cord-015306-us58wwmp 381 2 P p NN cord-015306-us58wwmp 381 3 - - HYPH cord-015306-us58wwmp 381 4 SAT056 sat056 NN cord-015306-us58wwmp 381 5 Weight weight NN cord-015306-us58wwmp 382 1 depending depend VBG cord-015306-us58wwmp 382 2 dosing dosing NN cord-015306-us58wwmp 382 3 of of IN cord-015306-us58wwmp 382 4 desmopressin desmopressin NNP cord-015306-us58wwmp 382 5 ( ( -LRB- cord-015306-us58wwmp 382 6 dDAVP dDAVP NNP cord-015306-us58wwmp 382 7 ) ) -RRB- cord-015306-us58wwmp 382 8 in in IN cord-015306-us58wwmp 382 9 nocturnal nocturnal JJ cord-015306-us58wwmp 382 10 enuresis enuresis NN cord-015306-us58wwmp 382 11 Pauline Pauline NNP cord-015306-us58wwmp 382 12 De De NNP cord-015306-us58wwmp 382 13 Bruyne Bruyne NNP cord-015306-us58wwmp 382 14 1 1 CD cord-015306-us58wwmp 382 15 , , , cord-015306-us58wwmp 382 16 Ann Ann NNP cord-015306-us58wwmp 382 17 De De NNP cord-015306-us58wwmp 382 18 Guchtenaere Guchtenaere NNP cord-015306-us58wwmp 382 19 1 1 CD cord-015306-us58wwmp 382 20 , , , cord-015306-us58wwmp 382 21 Charlotte Charlotte NNP cord-015306-us58wwmp 382 22 Van Van NNP cord-015306-us58wwmp 382 23 Herzeele Herzeele NNP cord-015306-us58wwmp 382 24 1 1 CD cord-015306-us58wwmp 382 25 , , , cord-015306-us58wwmp 382 26 Ann Ann NNP cord-015306-us58wwmp 382 27 Raes Raes NNP cord-015306-us58wwmp 382 28 1 1 CD cord-015306-us58wwmp 382 29 , , , cord-015306-us58wwmp 382 30 Jo Jo NNP cord-015306-us58wwmp 382 31 Dehoorne Dehoorne NNP cord-015306-us58wwmp 382 32 1 1 CD cord-015306-us58wwmp 382 33 Piet Piet NNP cord-015306-us58wwmp 382 34 Hoebeke Hoebeke NNP cord-015306-us58wwmp 382 35 2 2 CD cord-015306-us58wwmp 382 36 , , , cord-015306-us58wwmp 382 37 Erik Erik NNP cord-015306-us58wwmp 382 38 Van Van NNP cord-015306-us58wwmp 382 39 Laecke Laecke NNP cord-015306-us58wwmp 382 40 2 2 CD cord-015306-us58wwmp 382 41 , , , cord-015306-us58wwmp 382 42 Johan Johan NNP cord-015306-us58wwmp 382 43 VandeWalle VandeWalle NNP cord-015306-us58wwmp 382 44 1 1 CD cord-015306-us58wwmp 382 45 1 1 CD cord-015306-us58wwmp 382 46 Paediatric Paediatric NNP cord-015306-us58wwmp 382 47 Nephrology Nephrology NNP cord-015306-us58wwmp 382 48 , , , cord-015306-us58wwmp 382 49 Ghent Ghent NNP cord-015306-us58wwmp 382 50 University University NNP cord-015306-us58wwmp 382 51 Hospital Hospital NNP cord-015306-us58wwmp 382 52 , , , cord-015306-us58wwmp 382 53 Ghent Ghent NNP cord-015306-us58wwmp 382 54 , , , cord-015306-us58wwmp 382 55 Belgium Belgium NNP cord-015306-us58wwmp 382 56 2 2 CD cord-015306-us58wwmp 382 57 Department Department NNP cord-015306-us58wwmp 382 58 of of IN cord-015306-us58wwmp 382 59 Urology Urology NNP cord-015306-us58wwmp 382 60 , , , cord-015306-us58wwmp 382 61 Ghent Ghent NNP cord-015306-us58wwmp 382 62 University University NNP cord-015306-us58wwmp 382 63 Hospital Hospital NNP cord-015306-us58wwmp 382 64 , , , cord-015306-us58wwmp 382 65 Ghent Ghent NNP cord-015306-us58wwmp 382 66 , , , cord-015306-us58wwmp 383 1 Belgium Belgium NNP cord-015306-us58wwmp 383 2 Objective Objective NNP cord-015306-us58wwmp 383 3 : : : cord-015306-us58wwmp 384 1 In in IN cord-015306-us58wwmp 384 2 children child NNS cord-015306-us58wwmp 384 3 as as RB cord-015306-us58wwmp 384 4 well well RB cord-015306-us58wwmp 384 5 as as IN cord-015306-us58wwmp 384 6 in in IN cord-015306-us58wwmp 384 7 adults adult NNS cord-015306-us58wwmp 384 8 , , , cord-015306-us58wwmp 384 9 a a DT cord-015306-us58wwmp 384 10 uniform uniform JJ cord-015306-us58wwmp 384 11 starting starting NN cord-015306-us58wwmp 384 12 dose dose NN cord-015306-us58wwmp 384 13 of of IN cord-015306-us58wwmp 384 14 desmopressin desmopressin NNP cord-015306-us58wwmp 384 15 is be VBZ cord-015306-us58wwmp 384 16 prescribed prescribe VBN cord-015306-us58wwmp 384 17 . . . cord-015306-us58wwmp 385 1 This this DT cord-015306-us58wwmp 385 2 uniformity uniformity NN cord-015306-us58wwmp 385 3 is be VBZ cord-015306-us58wwmp 385 4 based base VBN cord-015306-us58wwmp 385 5 on on IN cord-015306-us58wwmp 385 6 the the DT cord-015306-us58wwmp 385 7 inability inability NN cord-015306-us58wwmp 385 8 to to TO cord-015306-us58wwmp 385 9 detect detect VB cord-015306-us58wwmp 385 10 a a DT cord-015306-us58wwmp 385 11 weight weight NN cord-015306-us58wwmp 385 12 - - HYPH cord-015306-us58wwmp 385 13 dependent dependent JJ cord-015306-us58wwmp 385 14 dose dose NN cord-015306-us58wwmp 385 15 - - HYPH cord-015306-us58wwmp 385 16 concentration concentration NN cord-015306-us58wwmp 385 17 correlation correlation NN cord-015306-us58wwmp 385 18 as as IN cord-015306-us58wwmp 385 19 this this DT cord-015306-us58wwmp 385 20 correlation correlation NN cord-015306-us58wwmp 385 21 is be VBZ cord-015306-us58wwmp 385 22 probably probably RB cord-015306-us58wwmp 385 23 blurred blur VBN cord-015306-us58wwmp 385 24 by by IN cord-015306-us58wwmp 385 25 the the DT cord-015306-us58wwmp 385 26 wide wide JJ cord-015306-us58wwmp 385 27 intra intra JJ cord-015306-us58wwmp 385 28 - - JJ cord-015306-us58wwmp 385 29 and and CC cord-015306-us58wwmp 385 30 interindividual interindividual JJ cord-015306-us58wwmp 385 31 differences difference NNS cord-015306-us58wwmp 385 32 in in IN cord-015306-us58wwmp 385 33 plasma plasma NN cord-015306-us58wwmp 385 34 concentration concentration NN cord-015306-us58wwmp 385 35 for for IN cord-015306-us58wwmp 385 36 a a DT cord-015306-us58wwmp 385 37 fixed fix VBN cord-015306-us58wwmp 385 38 desmopressin desmopressin NN cord-015306-us58wwmp 385 39 dose dose NN cord-015306-us58wwmp 385 40 . . . cord-015306-us58wwmp 386 1 Recently recently RB cord-015306-us58wwmp 386 2 , , , cord-015306-us58wwmp 386 3 a a DT cord-015306-us58wwmp 386 4 smaller small JJR cord-015306-us58wwmp 386 5 variation variation NN cord-015306-us58wwmp 386 6 in in IN cord-015306-us58wwmp 386 7 plasma plasma NN cord-015306-us58wwmp 386 8 concentration concentration NN cord-015306-us58wwmp 386 9 was be VBD cord-015306-us58wwmp 386 10 shown show VBN cord-015306-us58wwmp 386 11 for for IN cord-015306-us58wwmp 386 12 the the DT cord-015306-us58wwmp 386 13 oral oral JJ cord-015306-us58wwmp 386 14 lyophilisate lyophilisate NNP cord-015306-us58wwmp 386 15 formulation formulation NNP cord-015306-us58wwmp 386 16 of of IN cord-015306-us58wwmp 386 17 desmopressin desmopressin NNP cord-015306-us58wwmp 386 18 ( ( -LRB- cord-015306-us58wwmp 386 19 compared compare VBN cord-015306-us58wwmp 386 20 to to IN cord-015306-us58wwmp 386 21 tablet tablet NN cord-015306-us58wwmp 386 22 formulation formulation NN cord-015306-us58wwmp 386 23 ) ) -RRB- cord-015306-us58wwmp 386 24 . . . cord-015306-us58wwmp 387 1 Therefore therefore RB cord-015306-us58wwmp 387 2 , , , cord-015306-us58wwmp 387 3 this this DT cord-015306-us58wwmp 387 4 study study NN cord-015306-us58wwmp 387 5 assessed assess VBD cord-015306-us58wwmp 387 6 a a DT cord-015306-us58wwmp 387 7 possible possible JJ cord-015306-us58wwmp 387 8 correlation correlation NN cord-015306-us58wwmp 387 9 between between IN cord-015306-us58wwmp 387 10 weight weight NN cord-015306-us58wwmp 387 11 - - HYPH cord-015306-us58wwmp 387 12 corrected correct VBN cord-015306-us58wwmp 387 13 dose dose NN cord-015306-us58wwmp 387 14 and and CC cord-015306-us58wwmp 387 15 plasma plasma NN cord-015306-us58wwmp 387 16 concentration concentration NN cord-015306-us58wwmp 387 17 for for IN cord-015306-us58wwmp 387 18 both both DT cord-015306-us58wwmp 387 19 formulations formulation NNS cord-015306-us58wwmp 387 20 . . . cord-015306-us58wwmp 388 1 Methods method NNS cord-015306-us58wwmp 388 2 : : : cord-015306-us58wwmp 388 3 23 23 CD cord-015306-us58wwmp 388 4 children child NNS cord-015306-us58wwmp 388 5 with with IN cord-015306-us58wwmp 388 6 monosymptomatic monosymptomatic JJ cord-015306-us58wwmp 388 7 nocturnal nocturnal JJ cord-015306-us58wwmp 388 8 enuresis enuresis NN cord-015306-us58wwmp 388 9 were be VBD cord-015306-us58wwmp 388 10 recruited recruit VBN cord-015306-us58wwmp 388 11 in in IN cord-015306-us58wwmp 388 12 a a DT cord-015306-us58wwmp 388 13 tertiary tertiary JJ cord-015306-us58wwmp 388 14 centre centre NN cord-015306-us58wwmp 388 15 . . . cord-015306-us58wwmp 389 1 Two two CD cord-015306-us58wwmp 389 2 tests test NNS cord-015306-us58wwmp 389 3 were be VBD cord-015306-us58wwmp 389 4 performed perform VBN cord-015306-us58wwmp 389 5 on on IN cord-015306-us58wwmp 389 6 two two CD cord-015306-us58wwmp 389 7 separate separate JJ cord-015306-us58wwmp 389 8 days day NNS cord-015306-us58wwmp 389 9 ( ( -LRB- cord-015306-us58wwmp 389 10 at at IN cord-015306-us58wwmp 389 11 two two CD cord-015306-us58wwmp 389 12 weeks week NNS cord-015306-us58wwmp 389 13 interval interval NN cord-015306-us58wwmp 389 14 ) ) -RRB- cord-015306-us58wwmp 389 15 in in IN cord-015306-us58wwmp 389 16 identical identical JJ cord-015306-us58wwmp 389 17 , , , cord-015306-us58wwmp 389 18 standardized standardized JJ cord-015306-us58wwmp 389 19 conditions condition NNS cord-015306-us58wwmp 389 20 : : : cord-015306-us58wwmp 389 21 on on IN cord-015306-us58wwmp 389 22 day day NN cord-015306-us58wwmp 389 23 1 1 CD cord-015306-us58wwmp 389 24 desmopressin desmopressin NNP cord-015306-us58wwmp 389 25 tablet tablet NN cord-015306-us58wwmp 389 26 200μg 200μg NNS cord-015306-us58wwmp 389 27 and and CC cord-015306-us58wwmp 389 28 on on IN cord-015306-us58wwmp 389 29 day day NN cord-015306-us58wwmp 389 30 2 2 CD cord-015306-us58wwmp 389 31 desmopressin desmopressin NNP cord-015306-us58wwmp 389 32 oral oral JJ cord-015306-us58wwmp 389 33 lyophilisate lyophilisate NNP cord-015306-us58wwmp 389 34 120μg 120μg NNP cord-015306-us58wwmp 389 35 was be VBD cord-015306-us58wwmp 389 36 administered administer VBN cord-015306-us58wwmp 389 37 . . . cord-015306-us58wwmp 390 1 Plasma plasma NN cord-015306-us58wwmp 390 2 concentrations concentration NNS cord-015306-us58wwmp 390 3 were be VBD cord-015306-us58wwmp 390 4 measured measure VBN cord-015306-us58wwmp 390 5 at at IN cord-015306-us58wwmp 390 6 one one CD cord-015306-us58wwmp 390 7 , , , cord-015306-us58wwmp 390 8 two two CD cord-015306-us58wwmp 390 9 and and CC cord-015306-us58wwmp 390 10 six six CD cord-015306-us58wwmp 390 11 hours hour NNS cord-015306-us58wwmp 390 12 post post VBP cord-015306-us58wwmp 390 13 dosing dosing NN cord-015306-us58wwmp 390 14 . . . cord-015306-us58wwmp 391 1 The the DT cord-015306-us58wwmp 391 2 nonparametric nonparametric JJ cord-015306-us58wwmp 391 3 Spearman Spearman NNP cord-015306-us58wwmp 391 4 's 's POS cord-015306-us58wwmp 391 5 rank rank NN cord-015306-us58wwmp 391 6 correlation correlation NN cord-015306-us58wwmp 391 7 coefficient coefficient NN cord-015306-us58wwmp 391 8 was be VBD cord-015306-us58wwmp 391 9 used use VBN cord-015306-us58wwmp 391 10 for for IN cord-015306-us58wwmp 391 11 assessing assess VBG cord-015306-us58wwmp 391 12 the the DT cord-015306-us58wwmp 391 13 correlation correlation NN cord-015306-us58wwmp 391 14 between between IN cord-015306-us58wwmp 391 15 weight weight NN cord-015306-us58wwmp 391 16 corrected correct VBD cord-015306-us58wwmp 391 17 dose dose NN cord-015306-us58wwmp 391 18 and and CC cord-015306-us58wwmp 391 19 plasma plasma NN cord-015306-us58wwmp 391 20 concentration concentration NN cord-015306-us58wwmp 391 21 . . . cord-015306-us58wwmp 392 1 Results result NNS cord-015306-us58wwmp 392 2 : : : cord-015306-us58wwmp 393 1 Mean mean JJ cord-015306-us58wwmp 393 2 ( ( -LRB- cord-015306-us58wwmp 393 3 SD sd NN cord-015306-us58wwmp 393 4 ) ) -RRB- cord-015306-us58wwmp 393 5 age age NN cord-015306-us58wwmp 393 6 and and CC cord-015306-us58wwmp 393 7 body body NN cord-015306-us58wwmp 393 8 weight weight NN cord-015306-us58wwmp 393 9 of of IN cord-015306-us58wwmp 393 10 the the DT cord-015306-us58wwmp 393 11 patients patient NNS cord-015306-us58wwmp 393 12 were be VBD cord-015306-us58wwmp 393 13 respectively respectively RB cord-015306-us58wwmp 393 14 12.7 12.7 CD cord-015306-us58wwmp 393 15 ( ( -LRB- cord-015306-us58wwmp 393 16 2.9 2.9 CD cord-015306-us58wwmp 393 17 ) ) -RRB- cord-015306-us58wwmp 393 18 years year NNS cord-015306-us58wwmp 393 19 and and CC cord-015306-us58wwmp 393 20 50.1 50.1 CD cord-015306-us58wwmp 393 21 ( ( -LRB- cord-015306-us58wwmp 393 22 15 15 CD cord-015306-us58wwmp 393 23 . . CD cord-015306-us58wwmp 393 24 2 2 LS cord-015306-us58wwmp 393 25 ) ) -RRB- cord-015306-us58wwmp 393 26 kg kg NNS cord-015306-us58wwmp 393 27 . . . cord-015306-us58wwmp 394 1 A a DT cord-015306-us58wwmp 394 2 positive positive JJ cord-015306-us58wwmp 394 3 correlation correlation NN cord-015306-us58wwmp 394 4 between between IN cord-015306-us58wwmp 394 5 plasma plasma NN cord-015306-us58wwmp 394 6 concentration concentration NN cord-015306-us58wwmp 394 7 of of IN cord-015306-us58wwmp 394 8 dDAVP dDAVP NNP cord-015306-us58wwmp 394 9 was be VBD cord-015306-us58wwmp 394 10 found find VBN cord-015306-us58wwmp 394 11 for for IN cord-015306-us58wwmp 394 12 the the DT cord-015306-us58wwmp 394 13 oral oral JJ cord-015306-us58wwmp 394 14 lyophilisate lyophilisate NNP cord-015306-us58wwmp 394 15 formulation formulation NN cord-015306-us58wwmp 394 16 at at IN cord-015306-us58wwmp 394 17 2 2 CD cord-015306-us58wwmp 394 18 hours hour NNS cord-015306-us58wwmp 394 19 ( ( -LRB- cord-015306-us58wwmp 394 20 P p NN cord-015306-us58wwmp 394 21 - - HYPH cord-015306-us58wwmp 394 22 value value NN cord-015306-us58wwmp 394 23 0,021 0,021 CD cord-015306-us58wwmp 394 24 ) ) -RRB- cord-015306-us58wwmp 394 25 and and CC cord-015306-us58wwmp 394 26 6 6 CD cord-015306-us58wwmp 394 27 hours hour NNS cord-015306-us58wwmp 394 28 ( ( -LRB- cord-015306-us58wwmp 394 29 Pvalue Pvalue NNP cord-015306-us58wwmp 394 30 0,005 0,005 CD cord-015306-us58wwmp 394 31 ) ) -RRB- cord-015306-us58wwmp 394 32 post post VBP cord-015306-us58wwmp 394 33 dosing dosing NN cord-015306-us58wwmp 394 34 . . . cord-015306-us58wwmp 395 1 This this DT cord-015306-us58wwmp 395 2 is be VBZ cord-015306-us58wwmp 395 3 not not RB cord-015306-us58wwmp 395 4 the the DT cord-015306-us58wwmp 395 5 case case NN cord-015306-us58wwmp 395 6 for for IN cord-015306-us58wwmp 395 7 the the DT cord-015306-us58wwmp 395 8 tablet tablet NN cord-015306-us58wwmp 395 9 formulation formulation NN cord-015306-us58wwmp 395 10 . . . cord-015306-us58wwmp 396 1 Results result NNS cord-015306-us58wwmp 396 2 are be VBP cord-015306-us58wwmp 396 3 shown show VBN cord-015306-us58wwmp 396 4 graphically graphically RB cord-015306-us58wwmp 396 5 in in IN cord-015306-us58wwmp 396 6 figure figure NN cord-015306-us58wwmp 396 7 1 1 CD cord-015306-us58wwmp 396 8 and and CC cord-015306-us58wwmp 396 9 2 2 CD cord-015306-us58wwmp 396 10 . . . cord-015306-us58wwmp 397 1 Figure figure NN cord-015306-us58wwmp 397 2 1 1 CD cord-015306-us58wwmp 397 3 and and CC cord-015306-us58wwmp 397 4 2 2 CD cord-015306-us58wwmp 397 5 : : : cord-015306-us58wwmp 398 1 correlation correlation NN cord-015306-us58wwmp 398 2 of of IN cord-015306-us58wwmp 398 3 dose dose NN cord-015306-us58wwmp 398 4 corrected correct VBN cord-015306-us58wwmp 398 5 by by IN cord-015306-us58wwmp 398 6 weight weight NN cord-015306-us58wwmp 398 7 to to IN cord-015306-us58wwmp 398 8 plasma plasma NN cord-015306-us58wwmp 398 9 concentrations concentration NNS cord-015306-us58wwmp 398 10 at at IN cord-015306-us58wwmp 398 11 2 2 CD cord-015306-us58wwmp 398 12 and and CC cord-015306-us58wwmp 398 13 6 6 CD cord-015306-us58wwmp 398 14 hours hour NNS cord-015306-us58wwmp 399 1 post post NNP cord-015306-us58wwmp 399 2 dosing dosing NNP cord-015306-us58wwmp 399 3 Conclusion conclusion NN cord-015306-us58wwmp 399 4 : : : cord-015306-us58wwmp 400 1 To to IN cord-015306-us58wwmp 400 2 the the DT cord-015306-us58wwmp 400 3 best good JJS cord-015306-us58wwmp 400 4 of of IN cord-015306-us58wwmp 400 5 our -PRON- PRP$ cord-015306-us58wwmp 400 6 knowledge knowledge NN cord-015306-us58wwmp 400 7 , , , cord-015306-us58wwmp 400 8 this this DT cord-015306-us58wwmp 400 9 is be VBZ cord-015306-us58wwmp 400 10 the the DT cord-015306-us58wwmp 400 11 first first JJ cord-015306-us58wwmp 400 12 pharmacokinetic pharmacokinetic JJ cord-015306-us58wwmp 400 13 study study NN cord-015306-us58wwmp 400 14 showing show VBG cord-015306-us58wwmp 400 15 a a DT cord-015306-us58wwmp 400 16 significant significant JJ cord-015306-us58wwmp 400 17 dose dose NN cord-015306-us58wwmp 400 18 ( ( -LRB- cord-015306-us58wwmp 400 19 normalized normalize VBN cord-015306-us58wwmp 400 20 for for IN cord-015306-us58wwmp 400 21 size size NN cord-015306-us58wwmp 400 22 ) ) -RRB- cord-015306-us58wwmp 401 1 -concentration -concentration NN cord-015306-us58wwmp 401 2 correlation correlation NN cord-015306-us58wwmp 401 3 for for IN cord-015306-us58wwmp 401 4 desmopressin desmopressin NNP cord-015306-us58wwmp 401 5 . . . cord-015306-us58wwmp 402 1 Nevertheless nevertheless RB cord-015306-us58wwmp 402 2 , , , cord-015306-us58wwmp 402 3 this this DT cord-015306-us58wwmp 402 4 correlation correlation NN cord-015306-us58wwmp 402 5 was be VBD cord-015306-us58wwmp 402 6 only only RB cord-015306-us58wwmp 402 7 significant significant JJ cord-015306-us58wwmp 402 8 for for IN cord-015306-us58wwmp 402 9 the the DT cord-015306-us58wwmp 402 10 oral oral JJ cord-015306-us58wwmp 402 11 lyophilisate lyophilisate NNP cord-015306-us58wwmp 402 12 group group NNP cord-015306-us58wwmp 402 13 . . . cord-015306-us58wwmp 403 1 This this DT cord-015306-us58wwmp 403 2 result result NN cord-015306-us58wwmp 403 3 is be VBZ cord-015306-us58wwmp 403 4 clinically clinically RB cord-015306-us58wwmp 403 5 important important JJ cord-015306-us58wwmp 403 6 as as IN cord-015306-us58wwmp 403 7 it -PRON- PRP cord-015306-us58wwmp 403 8 is be VBZ cord-015306-us58wwmp 403 9 a a DT cord-015306-us58wwmp 403 10 strong strong JJ cord-015306-us58wwmp 403 11 indication indication NN cord-015306-us58wwmp 403 12 for for IN cord-015306-us58wwmp 403 13 more more RBR cord-015306-us58wwmp 403 14 predictable predictable JJ cord-015306-us58wwmp 403 15 plasma plasma NN cord-015306-us58wwmp 403 16 concentrations concentration NNS cord-015306-us58wwmp 403 17 for for IN cord-015306-us58wwmp 403 18 the the DT cord-015306-us58wwmp 403 19 oral oral JJ cord-015306-us58wwmp 403 20 lyophilisate lyophilisate NNP cord-015306-us58wwmp 403 21 formulation formulation NNP cord-015306-us58wwmp 403 22 , , , cord-015306-us58wwmp 403 23 and and CC cord-015306-us58wwmp 403 24 thus thus RB cord-015306-us58wwmp 403 25 preventing prevent VBG cord-015306-us58wwmp 403 26 elevated elevated JJ cord-015306-us58wwmp 403 27 concentrations concentration NNS cord-015306-us58wwmp 403 28 of of IN cord-015306-us58wwmp 403 29 desmopressin desmopressin NNS cord-015306-us58wwmp 403 30 . . . cord-015306-us58wwmp 404 1 Objective objective NN cord-015306-us58wwmp 404 2 : : : cord-015306-us58wwmp 405 1 Increased increase VBN cord-015306-us58wwmp 405 2 nocturnal nocturnal JJ cord-015306-us58wwmp 405 3 urine urine NN cord-015306-us58wwmp 405 4 production production NN cord-015306-us58wwmp 405 5 and/or and/or CC cord-015306-us58wwmp 405 6 bladder bladder NN cord-015306-us58wwmp 405 7 hyperactivity hyperactivity NN cord-015306-us58wwmp 405 8 in in IN cord-015306-us58wwmp 405 9 primary primary JJ cord-015306-us58wwmp 405 10 nocturnal nocturnal JJ cord-015306-us58wwmp 405 11 enuretic enuretic NN cord-015306-us58wwmp 406 1 ( ( -LRB- cord-015306-us58wwmp 406 2 NE NE NNP cord-015306-us58wwmp 406 3 ) ) -RRB- cord-015306-us58wwmp 406 4 patients patient NNS cord-015306-us58wwmp 406 5 could could MD cord-015306-us58wwmp 406 6 possibly possibly RB cord-015306-us58wwmp 406 7 be be VB cord-015306-us58wwmp 406 8 associated associate VBN cord-015306-us58wwmp 406 9 with with IN cord-015306-us58wwmp 406 10 autonomic autonomic JJ cord-015306-us58wwmp 406 11 nervous nervous JJ cord-015306-us58wwmp 406 12 system system NN cord-015306-us58wwmp 406 13 dysfunction dysfunction NN cord-015306-us58wwmp 406 14 . . . cord-015306-us58wwmp 407 1 Reports report NNS cord-015306-us58wwmp 407 2 of of IN cord-015306-us58wwmp 407 3 studies study NNS cord-015306-us58wwmp 407 4 on on IN cord-015306-us58wwmp 407 5 autonomic autonomic JJ cord-015306-us58wwmp 407 6 nervous nervous JJ cord-015306-us58wwmp 407 7 system system NN cord-015306-us58wwmp 407 8 dysfunction dysfunction NN cord-015306-us58wwmp 407 9 in in IN cord-015306-us58wwmp 407 10 NE NE NNP cord-015306-us58wwmp 407 11 are be VBP cord-015306-us58wwmp 407 12 limited limited JJ cord-015306-us58wwmp 407 13 . . . cord-015306-us58wwmp 408 1 To to TO cord-015306-us58wwmp 408 2 investigate investigate VB cord-015306-us58wwmp 408 3 autonomic autonomic JJ cord-015306-us58wwmp 408 4 nervous nervous JJ cord-015306-us58wwmp 408 5 system system NN cord-015306-us58wwmp 408 6 function function NN cord-015306-us58wwmp 408 7 in in IN cord-015306-us58wwmp 408 8 enuretic enuretic JJ cord-015306-us58wwmp 408 9 children child NNS cord-015306-us58wwmp 408 10 by by IN cord-015306-us58wwmp 408 11 performing perform VBG cord-015306-us58wwmp 408 12 ambulatory ambulatory JJ cord-015306-us58wwmp 408 13 blood blood NN cord-015306-us58wwmp 408 14 pressure pressure NN cord-015306-us58wwmp 408 15 monitorisation monitorisation NN cord-015306-us58wwmp 408 16 ( ( -LRB- cord-015306-us58wwmp 408 17 ABPM ABPM NNP cord-015306-us58wwmp 408 18 ) ) -RRB- cord-015306-us58wwmp 408 19 for for IN cord-015306-us58wwmp 408 20 24 24 CD cord-015306-us58wwmp 408 21 hours hour NNS cord-015306-us58wwmp 408 22 . . . cord-015306-us58wwmp 409 1 Methods method NNS cord-015306-us58wwmp 409 2 : : : cord-015306-us58wwmp 409 3 Children child NNS cord-015306-us58wwmp 409 4 with with IN cord-015306-us58wwmp 409 5 primary primary JJ cord-015306-us58wwmp 409 6 NE NE NNP cord-015306-us58wwmp 409 7 were be VBD cord-015306-us58wwmp 409 8 enrolled enrol VBN cord-015306-us58wwmp 409 9 in in IN cord-015306-us58wwmp 409 10 this this DT cord-015306-us58wwmp 409 11 study study NN cord-015306-us58wwmp 409 12 and and CC cord-015306-us58wwmp 409 13 they -PRON- PRP cord-015306-us58wwmp 409 14 get get VBP cord-015306-us58wwmp 409 15 24 24 CD cord-015306-us58wwmp 409 16 hour hour NN cord-015306-us58wwmp 409 17 ABPM ABPM NNP cord-015306-us58wwmp 409 18 . . . cord-015306-us58wwmp 410 1 Their -PRON- PRP$ cord-015306-us58wwmp 410 2 results result NNS cord-015306-us58wwmp 410 3 were be VBD cord-015306-us58wwmp 410 4 compared compare VBN cord-015306-us58wwmp 410 5 with with IN cord-015306-us58wwmp 410 6 healthy healthy JJ cord-015306-us58wwmp 410 7 children child NNS cord-015306-us58wwmp 410 8 . . . cord-015306-us58wwmp 411 1 Urinalysis urinalysis NN cord-015306-us58wwmp 411 2 , , , cord-015306-us58wwmp 411 3 urine urine NN cord-015306-us58wwmp 411 4 electrolyte electrolyte JJ cord-015306-us58wwmp 411 5 levels level NNS cord-015306-us58wwmp 411 6 , , , cord-015306-us58wwmp 411 7 urinary urinary JJ cord-015306-us58wwmp 411 8 culture culture NN cord-015306-us58wwmp 411 9 and and CC cord-015306-us58wwmp 411 10 urinary urinary JJ cord-015306-us58wwmp 411 11 system system NN cord-015306-us58wwmp 411 12 ultrasound ultrasound NN cord-015306-us58wwmp 411 13 were be VBD cord-015306-us58wwmp 411 14 carried carry VBN cord-015306-us58wwmp 411 15 out out RP cord-015306-us58wwmp 411 16 in in IN cord-015306-us58wwmp 411 17 all all PDT cord-015306-us58wwmp 411 18 the the DT cord-015306-us58wwmp 411 19 children child NNS cord-015306-us58wwmp 411 20 . . . cord-015306-us58wwmp 412 1 They -PRON- PRP cord-015306-us58wwmp 412 2 also also RB cord-015306-us58wwmp 412 3 requested request VBD cord-015306-us58wwmp 412 4 to to TO cord-015306-us58wwmp 412 5 have have VB cord-015306-us58wwmp 412 6 a a DT cord-015306-us58wwmp 412 7 diary diary NN cord-015306-us58wwmp 412 8 about about IN cord-015306-us58wwmp 412 9 daily daily JJ cord-015306-us58wwmp 412 10 fluid fluid JJ cord-015306-us58wwmp 412 11 intake intake NN cord-015306-us58wwmp 412 12 and and CC cord-015306-us58wwmp 412 13 volume volume NN cord-015306-us58wwmp 412 14 of of IN cord-015306-us58wwmp 412 15 daily daily JJ cord-015306-us58wwmp 412 16 urine urine NN cord-015306-us58wwmp 412 17 . . . cord-015306-us58wwmp 413 1 Results result NNS cord-015306-us58wwmp 413 2 : : : cord-015306-us58wwmp 414 1 The the DT cord-015306-us58wwmp 414 2 enuretic enuretic JJ cord-015306-us58wwmp 414 3 group group NN cord-015306-us58wwmp 414 4 consisted consist VBD cord-015306-us58wwmp 414 5 of of IN cord-015306-us58wwmp 414 6 28 28 CD cord-015306-us58wwmp 414 7 children child NNS cord-015306-us58wwmp 414 8 ( ( -LRB- cord-015306-us58wwmp 414 9 M M NNP cord-015306-us58wwmp 414 10 / / SYM cord-015306-us58wwmp 414 11 F:19/9 f:19/9 NN cord-015306-us58wwmp 414 12 ) ) -RRB- cord-015306-us58wwmp 414 13 and and CC cord-015306-us58wwmp 414 14 the the DT cord-015306-us58wwmp 414 15 control control NN cord-015306-us58wwmp 414 16 group group NN cord-015306-us58wwmp 414 17 of of IN cord-015306-us58wwmp 414 18 27 27 CD cord-015306-us58wwmp 414 19 healthy healthy JJ cord-015306-us58wwmp 414 20 children child NNS cord-015306-us58wwmp 414 21 ( ( -LRB- cord-015306-us58wwmp 414 22 M M NNP cord-015306-us58wwmp 414 23 / / SYM cord-015306-us58wwmp 414 24 F:14/13 F:14/13 NNP cord-015306-us58wwmp 414 25 ) ) -RRB- cord-015306-us58wwmp 414 26 . . . cord-015306-us58wwmp 415 1 The the DT cord-015306-us58wwmp 415 2 mean mean JJ cord-015306-us58wwmp 415 3 ages age NNS cord-015306-us58wwmp 415 4 were be VBD cord-015306-us58wwmp 415 5 7.9±2.2 7.9±2.2 CD cord-015306-us58wwmp 415 6 years year NNS cord-015306-us58wwmp 415 7 and and CC cord-015306-us58wwmp 415 8 8.77±2.65 8.77±2.65 CD cord-015306-us58wwmp 415 9 years year NNS cord-015306-us58wwmp 415 10 , , , cord-015306-us58wwmp 415 11 respectively respectively RB cord-015306-us58wwmp 415 12 . . . cord-015306-us58wwmp 416 1 The the DT cord-015306-us58wwmp 416 2 mean mean JJ cord-015306-us58wwmp 416 3 24-hour 24-hour JJ cord-015306-us58wwmp 416 4 BP BP NNP cord-015306-us58wwmp 416 5 and and CC cord-015306-us58wwmp 416 6 daytime daytime NN cord-015306-us58wwmp 416 7 DBP DBP NNP cord-015306-us58wwmp 416 8 did do VBD cord-015306-us58wwmp 416 9 not not RB cord-015306-us58wwmp 416 10 differ differ VB cord-015306-us58wwmp 416 11 between between IN cord-015306-us58wwmp 416 12 the the DT cord-015306-us58wwmp 416 13 groups group NNS cord-015306-us58wwmp 416 14 however however RB cord-015306-us58wwmp 416 15 , , , cord-015306-us58wwmp 416 16 the the DT cord-015306-us58wwmp 416 17 mean mean JJ cord-015306-us58wwmp 416 18 systolic systolic JJ cord-015306-us58wwmp 416 19 BP BP NNP cord-015306-us58wwmp 416 20 was be VBD cord-015306-us58wwmp 416 21 significantly significantly RB cord-015306-us58wwmp 416 22 higher high JJR cord-015306-us58wwmp 416 23 in in IN cord-015306-us58wwmp 416 24 enuretic enuretic JJ cord-015306-us58wwmp 416 25 children child NNS cord-015306-us58wwmp 416 26 ( ( -LRB- cord-015306-us58wwmp 416 27 p<0.05 p<0.05 CD cord-015306-us58wwmp 416 28 ) ) -RRB- cord-015306-us58wwmp 416 29 . . . cord-015306-us58wwmp 417 1 The the DT cord-015306-us58wwmp 417 2 mean mean JJ cord-015306-us58wwmp 417 3 nighttime nighttime JJ cord-015306-us58wwmp 417 4 systolic systolic JJ cord-015306-us58wwmp 417 5 BP BP NNP cord-015306-us58wwmp 417 6 , , , cord-015306-us58wwmp 417 7 DBP DBP NNP cord-015306-us58wwmp 417 8 and and CC cord-015306-us58wwmp 417 9 MAP MAP NNP cord-015306-us58wwmp 417 10 were be VBD cord-015306-us58wwmp 417 11 significantly significantly RB cord-015306-us58wwmp 417 12 higher high JJR cord-015306-us58wwmp 417 13 as as RB cord-015306-us58wwmp 417 14 well well RB cord-015306-us58wwmp 417 15 in in IN cord-015306-us58wwmp 417 16 the the DT cord-015306-us58wwmp 417 17 patient patient NN cord-015306-us58wwmp 417 18 group group NN cord-015306-us58wwmp 417 19 . . . cord-015306-us58wwmp 418 1 Daytime Daytime NNP cord-015306-us58wwmp 418 2 BP BP NNP cord-015306-us58wwmp 418 3 load load NN cord-015306-us58wwmp 418 4 did do VBD cord-015306-us58wwmp 418 5 not not RB cord-015306-us58wwmp 418 6 found find VBN cord-015306-us58wwmp 418 7 to to TO cord-015306-us58wwmp 418 8 be be VB cord-015306-us58wwmp 418 9 elevated elevate VBN cord-015306-us58wwmp 418 10 in in IN cord-015306-us58wwmp 418 11 both both DT cord-015306-us58wwmp 418 12 groups group NNS cord-015306-us58wwmp 418 13 . . . cord-015306-us58wwmp 419 1 Elevated elevated JJ cord-015306-us58wwmp 419 2 night night NN cord-015306-us58wwmp 419 3 time time NN cord-015306-us58wwmp 419 4 systolic systolic JJ cord-015306-us58wwmp 419 5 BP BP NNP cord-015306-us58wwmp 419 6 load load NN cord-015306-us58wwmp 419 7 was be VBD cord-015306-us58wwmp 419 8 observed observe VBN cord-015306-us58wwmp 419 9 in in IN cord-015306-us58wwmp 419 10 4 4 CD cord-015306-us58wwmp 419 11 patients patient NNS cord-015306-us58wwmp 419 12 and and CC cord-015306-us58wwmp 419 13 was be VBD cord-015306-us58wwmp 419 14 not not RB cord-015306-us58wwmp 419 15 observed observe VBN cord-015306-us58wwmp 419 16 in in IN cord-015306-us58wwmp 419 17 control control NN cord-015306-us58wwmp 419 18 group group NN cord-015306-us58wwmp 419 19 ( ( -LRB- cord-015306-us58wwmp 419 20 14.2 14.2 CD cord-015306-us58wwmp 419 21 % % NN cord-015306-us58wwmp 419 22 vs vs IN cord-015306-us58wwmp 419 23 0 0 CD cord-015306-us58wwmp 419 24 % % NN cord-015306-us58wwmp 419 25 ) ) -RRB- cord-015306-us58wwmp 419 26 ( ( -LRB- cord-015306-us58wwmp 419 27 p<0.01 p<0.01 NNP cord-015306-us58wwmp 419 28 ) ) -RRB- cord-015306-us58wwmp 419 29 . . . cord-015306-us58wwmp 420 1 Nighttime nighttime JJ cord-015306-us58wwmp 420 2 diastolic diastolic JJ cord-015306-us58wwmp 420 3 BP BP NNP cord-015306-us58wwmp 420 4 load load NN cord-015306-us58wwmp 420 5 was be VBD cord-015306-us58wwmp 420 6 elevated elevate VBN cord-015306-us58wwmp 420 7 in in IN cord-015306-us58wwmp 420 8 7 7 CD cord-015306-us58wwmp 420 9 of of IN cord-015306-us58wwmp 420 10 28 28 CD cord-015306-us58wwmp 420 11 patients patient NNS cord-015306-us58wwmp 420 12 , , , cord-015306-us58wwmp 420 13 compared compare VBN cord-015306-us58wwmp 420 14 with with IN cord-015306-us58wwmp 420 15 1 1 CD cord-015306-us58wwmp 420 16 of of IN cord-015306-us58wwmp 420 17 27 27 CD cord-015306-us58wwmp 420 18 control control NN cord-015306-us58wwmp 420 19 subjects subject NNS cord-015306-us58wwmp 420 20 ( ( -LRB- cord-015306-us58wwmp 420 21 p<0.01 p<0.01 NNP cord-015306-us58wwmp 420 22 ) ) -RRB- cord-015306-us58wwmp 420 23 . . . cord-015306-us58wwmp 421 1 The the DT cord-015306-us58wwmp 421 2 nocturnal nocturnal JJ cord-015306-us58wwmp 421 3 BP BP NNP cord-015306-us58wwmp 421 4 dip dip NN cord-015306-us58wwmp 421 5 was be VBD cord-015306-us58wwmp 421 6 significantly significantly RB cord-015306-us58wwmp 421 7 reduced reduce VBN cord-015306-us58wwmp 421 8 in in IN cord-015306-us58wwmp 421 9 the the DT cord-015306-us58wwmp 421 10 patient patient NN cord-015306-us58wwmp 421 11 group group NN cord-015306-us58wwmp 421 12 compared compare VBN cord-015306-us58wwmp 421 13 with with IN cord-015306-us58wwmp 421 14 control control NN cord-015306-us58wwmp 421 15 group group NN cord-015306-us58wwmp 421 16 for for IN cord-015306-us58wwmp 421 17 diastolic diastolic JJ cord-015306-us58wwmp 421 18 blood blood NN cord-015306-us58wwmp 421 19 pressure pressure NN cord-015306-us58wwmp 421 20 ( ( -LRB- cord-015306-us58wwmp 421 21 67.8 67.8 CD cord-015306-us58wwmp 421 22 % % NN cord-015306-us58wwmp 421 23 vs vs IN cord-015306-us58wwmp 421 24 14.7 14.7 CD cord-015306-us58wwmp 421 25 % % NN cord-015306-us58wwmp 421 26 , , , cord-015306-us58wwmp 421 27 respectively respectively RB cord-015306-us58wwmp 421 28 ; ; : cord-015306-us58wwmp 421 29 p=0.037 p=0.037 NNP cord-015306-us58wwmp 421 30 ) ) -RRB- cord-015306-us58wwmp 421 31 . . . cord-015306-us58wwmp 422 1 Patients patient NNS cord-015306-us58wwmp 422 2 with with IN cord-015306-us58wwmp 422 3 elevated elevated JJ cord-015306-us58wwmp 422 4 night night NN cord-015306-us58wwmp 422 5 time time NN cord-015306-us58wwmp 422 6 BP BP NNP cord-015306-us58wwmp 422 7 load load NN cord-015306-us58wwmp 422 8 was be VBD cord-015306-us58wwmp 422 9 found find VBN cord-015306-us58wwmp 422 10 to to TO cord-015306-us58wwmp 422 11 have have VB cord-015306-us58wwmp 422 12 higher high JJR cord-015306-us58wwmp 422 13 frequency frequency NN cord-015306-us58wwmp 422 14 of of IN cord-015306-us58wwmp 422 15 urinary urinary JJ cord-015306-us58wwmp 422 16 incontinence incontinence NN cord-015306-us58wwmp 422 17 per per IN cord-015306-us58wwmp 422 18 week week NN cord-015306-us58wwmp 422 19 as as RB cord-015306-us58wwmp 422 20 well well RB cord-015306-us58wwmp 422 21 as as IN cord-015306-us58wwmp 422 22 per per IN cord-015306-us58wwmp 422 23 night night NN cord-015306-us58wwmp 422 24 while while IN cord-015306-us58wwmp 422 25 compared compare VBN cord-015306-us58wwmp 422 26 with with IN cord-015306-us58wwmp 422 27 enuretic enuretic JJ cord-015306-us58wwmp 422 28 children child NNS cord-015306-us58wwmp 422 29 with with IN cord-015306-us58wwmp 422 30 normal normal JJ cord-015306-us58wwmp 422 31 night night NN cord-015306-us58wwmp 422 32 time time NN cord-015306-us58wwmp 422 33 BP BP NNP cord-015306-us58wwmp 422 34 load load NN cord-015306-us58wwmp 422 35 ( ( -LRB- cord-015306-us58wwmp 422 36 r=0.72 r=0.72 RB cord-015306-us58wwmp 422 37 , , , cord-015306-us58wwmp 422 38 p<0.01 p<0.01 JJ cord-015306-us58wwmp 422 39 ; ; : cord-015306-us58wwmp 422 40 r=0.69 r=0.69 NNP cord-015306-us58wwmp 422 41 , , , cord-015306-us58wwmp 422 42 p<0.01 p<0.01 NNP cord-015306-us58wwmp 422 43 respectively respectively RB cord-015306-us58wwmp 422 44 ) ) -RRB- cord-015306-us58wwmp 422 45 . . . cord-015306-us58wwmp 423 1 Conclusion conclusion NN cord-015306-us58wwmp 423 2 : : : cord-015306-us58wwmp 424 1 Nocturnal nocturnal JJ cord-015306-us58wwmp 424 2 BP BP NNP cord-015306-us58wwmp 424 3 loads load NNS cord-015306-us58wwmp 424 4 were be VBD cord-015306-us58wwmp 424 5 significantly significantly RB cord-015306-us58wwmp 424 6 higher high JJR cord-015306-us58wwmp 424 7 in in IN cord-015306-us58wwmp 424 8 children child NNS cord-015306-us58wwmp 424 9 with with IN cord-015306-us58wwmp 424 10 enuresis enuresis NN cord-015306-us58wwmp 424 11 . . . cord-015306-us58wwmp 425 1 These these DT cord-015306-us58wwmp 425 2 subtle subtle JJ cord-015306-us58wwmp 425 3 abnormalities abnormality NNS cord-015306-us58wwmp 425 4 of of IN cord-015306-us58wwmp 425 5 circadian circadian NN cord-015306-us58wwmp 425 6 blood blood NN cord-015306-us58wwmp 425 7 pressure pressure NN cord-015306-us58wwmp 425 8 regulation regulation NN cord-015306-us58wwmp 425 9 , , , cord-015306-us58wwmp 425 10 loss loss NN cord-015306-us58wwmp 425 11 of of IN cord-015306-us58wwmp 425 12 nocturnal nocturnal JJ cord-015306-us58wwmp 425 13 dip dip NN cord-015306-us58wwmp 425 14 and and CC cord-015306-us58wwmp 425 15 observation observation NN cord-015306-us58wwmp 425 16 of of IN cord-015306-us58wwmp 425 17 decreased decrease VBN cord-015306-us58wwmp 425 18 nocturnal nocturnal JJ cord-015306-us58wwmp 425 19 pulse pulse NN cord-015306-us58wwmp 425 20 rate rate NN cord-015306-us58wwmp 425 21 may may MD cord-015306-us58wwmp 425 22 reflect reflect VB cord-015306-us58wwmp 425 23 autonomic autonomic JJ cord-015306-us58wwmp 425 24 nervous nervous JJ cord-015306-us58wwmp 425 25 system system NN cord-015306-us58wwmp 425 26 dysfunction dysfunction NN cord-015306-us58wwmp 425 27 and and CC cord-015306-us58wwmp 425 28 pathogenesis pathogenesis NN cord-015306-us58wwmp 425 29 of of IN cord-015306-us58wwmp 425 30 EN EN NNP cord-015306-us58wwmp 425 31 . . . cord-015306-us58wwmp 426 1 Objective objective NN cord-015306-us58wwmp 426 2 : : : cord-015306-us58wwmp 427 1 Bladder bladder NN cord-015306-us58wwmp 427 2 dysfunction dysfunction NN cord-015306-us58wwmp 427 3 and and CC cord-015306-us58wwmp 427 4 especially especially RB cord-015306-us58wwmp 427 5 OAB OAB NNP cord-015306-us58wwmp 427 6 plays play VBZ cord-015306-us58wwmp 427 7 a a DT cord-015306-us58wwmp 427 8 major major JJ cord-015306-us58wwmp 427 9 role role NN cord-015306-us58wwmp 427 10 in in IN cord-015306-us58wwmp 427 11 nocturnal nocturnal JJ cord-015306-us58wwmp 427 12 enuresis enuresis NN cord-015306-us58wwmp 427 13 , , , cord-015306-us58wwmp 427 14 not not RB cord-015306-us58wwmp 427 15 only only RB cord-015306-us58wwmp 427 16 in in IN cord-015306-us58wwmp 427 17 the the DT cord-015306-us58wwmp 427 18 non non AFX cord-015306-us58wwmp 427 19 monosymptomatic monosymptomatic JJ cord-015306-us58wwmp 427 20 ( ( -LRB- cord-015306-us58wwmp 427 21 NMNE NMNE NNP cord-015306-us58wwmp 427 22 ) ) -RRB- cord-015306-us58wwmp 427 23 but but CC cord-015306-us58wwmp 427 24 as as RB cord-015306-us58wwmp 427 25 well well RB cord-015306-us58wwmp 427 26 in in IN cord-015306-us58wwmp 427 27 the the DT cord-015306-us58wwmp 427 28 monosymptomatic monosymptomatic JJ cord-015306-us58wwmp 427 29 patients patient NNS cord-015306-us58wwmp 427 30 ( ( -LRB- cord-015306-us58wwmp 427 31 MNE MNE NNP cord-015306-us58wwmp 427 32 ) ) -RRB- cord-015306-us58wwmp 427 33 . . . cord-015306-us58wwmp 428 1 If if IN cord-015306-us58wwmp 428 2 the the DT cord-015306-us58wwmp 428 3 enuresis enuresis NN cord-015306-us58wwmp 428 4 is be VBZ cord-015306-us58wwmp 428 5 related relate VBN cord-015306-us58wwmp 428 6 to to IN cord-015306-us58wwmp 428 7 a a DT cord-015306-us58wwmp 428 8 mismatch mismatch NN cord-015306-us58wwmp 428 9 in in IN cord-015306-us58wwmp 428 10 nocturnal nocturnal JJ cord-015306-us58wwmp 428 11 diuresis diuresis NN cord-015306-us58wwmp 428 12 and and CC cord-015306-us58wwmp 428 13 maximal maximal JJ cord-015306-us58wwmp 428 14 functional functional JJ cord-015306-us58wwmp 428 15 bladder bladder NN cord-015306-us58wwmp 428 16 capacity capacity NN cord-015306-us58wwmp 428 17 , , , cord-015306-us58wwmp 428 18 then then RB cord-015306-us58wwmp 428 19 the the DT cord-015306-us58wwmp 428 20 bladder bladder NN cord-015306-us58wwmp 428 21 volume volume NN cord-015306-us58wwmp 428 22 should should MD cord-015306-us58wwmp 428 23 be be VB cord-015306-us58wwmp 428 24 a a DT cord-015306-us58wwmp 428 25 major major JJ cord-015306-us58wwmp 428 26 parameter parameter NN cord-015306-us58wwmp 428 27 , , , cord-015306-us58wwmp 428 28 but but CC cord-015306-us58wwmp 428 29 is be VBZ cord-015306-us58wwmp 428 30 sofar sofar RB cord-015306-us58wwmp 428 31 not not RB cord-015306-us58wwmp 428 32 taken take VBN cord-015306-us58wwmp 428 33 as as IN cord-015306-us58wwmp 428 34 a a DT cord-015306-us58wwmp 428 35 parameter parameter NN cord-015306-us58wwmp 428 36 for for IN cord-015306-us58wwmp 428 37 subtyping subtyping NN cord-015306-us58wwmp 428 38 into into IN cord-015306-us58wwmp 428 39 NMNE NMNE NNP cord-015306-us58wwmp 428 40 in in IN cord-015306-us58wwmp 428 41 the the DT cord-015306-us58wwmp 428 42 ICCS ICCS NNP cord-015306-us58wwmp 428 43 standardization standardization NN cord-015306-us58wwmp 428 44 . . . cord-015306-us58wwmp 429 1 Maximal maximal JJ cord-015306-us58wwmp 429 2 voided void VBD cord-015306-us58wwmp 429 3 volume volume NN cord-015306-us58wwmp 429 4 in in IN cord-015306-us58wwmp 429 5 a a DT cord-015306-us58wwmp 429 6 diary diary NN cord-015306-us58wwmp 429 7 is be VBZ cord-015306-us58wwmp 429 8 the the DT cord-015306-us58wwmp 429 9 golden golden JJ cord-015306-us58wwmp 429 10 standard standard NN cord-015306-us58wwmp 429 11 , , , cord-015306-us58wwmp 429 12 although although IN cord-015306-us58wwmp 429 13 relation relation NN cord-015306-us58wwmp 429 14 with with IN cord-015306-us58wwmp 429 15 outcome outcome NN cord-015306-us58wwmp 429 16 is be VBZ cord-015306-us58wwmp 429 17 poorly poorly RB cord-015306-us58wwmp 429 18 studied study VBN cord-015306-us58wwmp 429 19 . . . cord-015306-us58wwmp 430 1 Methods method NNS cord-015306-us58wwmp 430 2 : : : cord-015306-us58wwmp 430 3 Aim aim VB cord-015306-us58wwmp 430 4 of of IN cord-015306-us58wwmp 430 5 the the DT cord-015306-us58wwmp 430 6 study study NN cord-015306-us58wwmp 430 7 was be VBD cord-015306-us58wwmp 430 8 to to TO cord-015306-us58wwmp 430 9 evaluate evaluate VB cord-015306-us58wwmp 430 10 the the DT cord-015306-us58wwmp 430 11 optimal optimal JJ cord-015306-us58wwmp 430 12 parameter parameter NN cord-015306-us58wwmp 430 13 for for IN cord-015306-us58wwmp 430 14 estimation estimation NN cord-015306-us58wwmp 430 15 of of IN cord-015306-us58wwmp 430 16 bladder bladder NN cord-015306-us58wwmp 430 17 volume volume NN cord-015306-us58wwmp 430 18 as as IN cord-015306-us58wwmp 430 19 maximal maximal JJ cord-015306-us58wwmp 430 20 voided void VBN cord-015306-us58wwmp 430 21 volume volume NN cord-015306-us58wwmp 430 22 in in IN cord-015306-us58wwmp 430 23 a a DT cord-015306-us58wwmp 430 24 diary diary NN cord-015306-us58wwmp 430 25 , , , cord-015306-us58wwmp 430 26 during during IN cord-015306-us58wwmp 430 27 forced force VBN cord-015306-us58wwmp 430 28 diuresis diuresis NN cord-015306-us58wwmp 430 29 , , , cord-015306-us58wwmp 430 30 bladder bladder NN cord-015306-us58wwmp 430 31 volume volume NN cord-015306-us58wwmp 430 32 during during IN cord-015306-us58wwmp 430 33 3 3 CD cord-015306-us58wwmp 430 34 uroflow uroflow NN cord-015306-us58wwmp 430 35 + + CC cord-015306-us58wwmp 430 36 uroflow uroflow NN cord-015306-us58wwmp 430 37 ) ) -RRB- cord-015306-us58wwmp 430 38 , , , cord-015306-us58wwmp 430 39 correlating correlate VBG cord-015306-us58wwmp 430 40 with with IN cord-015306-us58wwmp 430 41 cystomanometry cystomanometry NNP cord-015306-us58wwmp 430 42 ( ( -LRB- cord-015306-us58wwmp 430 43 if if IN cord-015306-us58wwmp 430 44 indicated indicate VBN cord-015306-us58wwmp 430 45 ) ) -RRB- cord-015306-us58wwmp 430 46 . . . cord-015306-us58wwmp 431 1 Studypopulation Studypopulation NNP cord-015306-us58wwmp 431 2 398 398 CD cord-015306-us58wwmp 431 3 patients patient NNS cord-015306-us58wwmp 431 4 age age NN cord-015306-us58wwmp 431 5 5 5 CD cord-015306-us58wwmp 431 6 to to TO cord-015306-us58wwmp 431 7 18 18 CD cord-015306-us58wwmp 431 8 years year NNS cord-015306-us58wwmp 431 9 , , , cord-015306-us58wwmp 431 10 > > XX cord-015306-us58wwmp 431 11 6/7days 6/7days RB cord-015306-us58wwmp 431 12 wet wet JJ cord-015306-us58wwmp 431 13 , , , cord-015306-us58wwmp 431 14 only only RB cord-015306-us58wwmp 431 15 48 48 CD cord-015306-us58wwmp 431 16 cystomanometries cystomanometrie NNS cord-015306-us58wwmp 431 17 . . . cord-015306-us58wwmp 432 1 Results result NNS cord-015306-us58wwmp 432 2 : : : cord-015306-us58wwmp 432 3 If if IN cord-015306-us58wwmp 432 4 we -PRON- PRP cord-015306-us58wwmp 432 5 compare compare VBP cord-015306-us58wwmp 432 6 the the DT cord-015306-us58wwmp 432 7 data datum NNS cord-015306-us58wwmp 432 8 from from IN cord-015306-us58wwmp 432 9 the the DT cord-015306-us58wwmp 432 10 bladder bladder NN cord-015306-us58wwmp 432 11 volume volume NN cord-015306-us58wwmp 432 12 against against IN cord-015306-us58wwmp 432 13 the the DT cord-015306-us58wwmp 432 14 reference reference NN cord-015306-us58wwmp 432 15 frame frame NN cord-015306-us58wwmp 432 16 from from IN cord-015306-us58wwmp 432 17 Rittig Rittig NNP cord-015306-us58wwmp 432 18 ( ( -LRB- cord-015306-us58wwmp 432 19 Aarhus Aarhus NNP cord-015306-us58wwmp 432 20 ) ) -RRB- cord-015306-us58wwmp 432 21 , , , cord-015306-us58wwmp 432 22 then then RB cord-015306-us58wwmp 432 23 60,4 60,4 CD cord-015306-us58wwmp 432 24 % % NN cord-015306-us58wwmp 432 25 of of IN cord-015306-us58wwmp 432 26 patients patient NNS cord-015306-us58wwmp 432 27 had have VBD cord-015306-us58wwmp 432 28 a a DT cord-015306-us58wwmp 432 29 MVV MVV NNP cord-015306-us58wwmp 432 30 in in IN cord-015306-us58wwmp 432 31 diary diary NN cord-015306-us58wwmp 432 32 < < XX cord-015306-us58wwmp 432 33 2,5 2,5 CD cord-015306-us58wwmp 432 34 % % NN cord-015306-us58wwmp 432 35 percentile percentile NN cord-015306-us58wwmp 432 36 demonstrating demonstrate VBG cord-015306-us58wwmp 432 37 that that IN cord-015306-us58wwmp 432 38 a a DT cord-015306-us58wwmp 432 39 majority majority NN cord-015306-us58wwmp 432 40 of of IN cord-015306-us58wwmp 432 41 patients patient NNS cord-015306-us58wwmp 432 42 had have VBD cord-015306-us58wwmp 432 43 a a DT cord-015306-us58wwmp 432 44 small small JJ cord-015306-us58wwmp 432 45 for for IN cord-015306-us58wwmp 432 46 age age NN cord-015306-us58wwmp 432 47 voided void VBN cord-015306-us58wwmp 432 48 volume volume NN cord-015306-us58wwmp 432 49 in in IN cord-015306-us58wwmp 432 50 their -PRON- PRP$ cord-015306-us58wwmp 432 51 diary diary NN cord-015306-us58wwmp 432 52 . . . cord-015306-us58wwmp 433 1 Correlation correlation NN cord-015306-us58wwmp 433 2 between between IN cord-015306-us58wwmp 433 3 MVVdiary MVVdiary NNP cord-015306-us58wwmp 433 4 , , , cord-015306-us58wwmp 433 5 MVV MVV NNP cord-015306-us58wwmp 433 6 forced force VBD cord-015306-us58wwmp 433 7 diuresis diuresis NN cord-015306-us58wwmp 433 8 , , , cord-015306-us58wwmp 433 9 bladder bladder NN cord-015306-us58wwmp 433 10 capacity capacity NN cord-015306-us58wwmp 433 11 ( ( -LRB- cord-015306-us58wwmp 433 12 uroflow+ uroflow+ NNP cord-015306-us58wwmp 433 13 residu residu NNP cord-015306-us58wwmp 433 14 ) ) -RRB- cord-015306-us58wwmp 433 15 and and CC cord-015306-us58wwmp 433 16 cystomanometry cystomanometry NNP cord-015306-us58wwmp 433 17 show show VBP cord-015306-us58wwmp 433 18 that that IN cord-015306-us58wwmp 433 19 there there EX cord-015306-us58wwmp 433 20 is be VBZ cord-015306-us58wwmp 433 21 a a DT cord-015306-us58wwmp 433 22 strong strong JJ cord-015306-us58wwmp 433 23 correlation correlation NN cord-015306-us58wwmp 433 24 between between IN cord-015306-us58wwmp 433 25 the the DT cord-015306-us58wwmp 433 26 4 4 CD cord-015306-us58wwmp 433 27 , , , cord-015306-us58wwmp 433 28 But but CC cord-015306-us58wwmp 433 29 especially especially RB cord-015306-us58wwmp 433 30 for for IN cord-015306-us58wwmp 433 31 the the DT cord-015306-us58wwmp 433 32 last last JJ cord-015306-us58wwmp 433 33 3 3 CD cord-015306-us58wwmp 433 34 parameters parameter NNS cord-015306-us58wwmp 433 35 ( ( -LRB- cord-015306-us58wwmp 433 36 r r NN cord-015306-us58wwmp 433 37 2 2 CD cord-015306-us58wwmp 433 38 0.48 0.48 CD cord-015306-us58wwmp 433 39 - - HYPH cord-015306-us58wwmp 433 40 0.62 0.62 CD cord-015306-us58wwmp 433 41 , , , cord-015306-us58wwmp 433 42 p p NN cord-015306-us58wwmp 433 43 < < XX cord-015306-us58wwmp 433 44 0.01),but 0.01),but CD cord-015306-us58wwmp 433 45 results result NNS cord-015306-us58wwmp 433 46 with with IN cord-015306-us58wwmp 433 47 MVV MVV NNP cord-015306-us58wwmp 433 48 diary diary NN cord-015306-us58wwmp 433 49 are be VBP cord-015306-us58wwmp 433 50 worse bad JJR cord-015306-us58wwmp 433 51 ( ( -LRB- cord-015306-us58wwmp 433 52 r r NN cord-015306-us58wwmp 433 53 2 2 CD cord-015306-us58wwmp 433 54 0.34 0.34 CD cord-015306-us58wwmp 433 55 - - HYPH cord-015306-us58wwmp 433 56 0.48 0.48 CD cord-015306-us58wwmp 433 57 , , , cord-015306-us58wwmp 433 58 p p NN cord-015306-us58wwmp 433 59 0.04 0.04 CD cord-015306-us58wwmp 433 60 - - SYM cord-015306-us58wwmp 433 61 0.018 0.018 CD cord-015306-us58wwmp 433 62 ) ) -RRB- cord-015306-us58wwmp 433 63 . . . cord-015306-us58wwmp 434 1 There there EX cord-015306-us58wwmp 434 2 is be VBZ cord-015306-us58wwmp 434 3 no no DT cord-015306-us58wwmp 434 4 sex sex NN cord-015306-us58wwmp 434 5 or or CC cord-015306-us58wwmp 434 6 gender gender NN cord-015306-us58wwmp 434 7 difference difference NN cord-015306-us58wwmp 434 8 in in IN cord-015306-us58wwmp 434 9 this this DT cord-015306-us58wwmp 434 10 observation observation NN cord-015306-us58wwmp 434 11 . . . cord-015306-us58wwmp 435 1 Correlation correlation NN cord-015306-us58wwmp 435 2 with with IN cord-015306-us58wwmp 435 3 response response NN cord-015306-us58wwmp 435 4 to to IN cord-015306-us58wwmp 435 5 therapy therapy NN cord-015306-us58wwmp 435 6 at at IN cord-015306-us58wwmp 435 7 1 1 CD cord-015306-us58wwmp 435 8 year year NN cord-015306-us58wwmp 435 9 shows show VBZ cord-015306-us58wwmp 435 10 a a DT cord-015306-us58wwmp 435 11 superior superior JJ cord-015306-us58wwmp 435 12 correlation correlation NN cord-015306-us58wwmp 435 13 with with IN cord-015306-us58wwmp 435 14 MVV MVV NNP cord-015306-us58wwmp 435 15 forced force VBD cord-015306-us58wwmp 435 16 diuresis diuresis NN cord-015306-us58wwmp 435 17 and and CC cord-015306-us58wwmp 435 18 during during IN cord-015306-us58wwmp 435 19 uroflow uroflow NN cord-015306-us58wwmp 435 20 than than IN cord-015306-us58wwmp 435 21 MVV MVV NNP cord-015306-us58wwmp 435 22 diary diary NN cord-015306-us58wwmp 435 23 ( ( -LRB- cord-015306-us58wwmp 435 24 p0.04 p0.04 NNP cord-015306-us58wwmp 435 25 ) ) -RRB- cord-015306-us58wwmp 435 26 . . . cord-015306-us58wwmp 436 1 Since since IN cord-015306-us58wwmp 436 2 cystomanometry cystomanometry NNP cord-015306-us58wwmp 436 3 is be VBZ cord-015306-us58wwmp 436 4 only only RB cord-015306-us58wwmp 436 5 performed perform VBN cord-015306-us58wwmp 436 6 in in IN cord-015306-us58wwmp 436 7 refractory refractory JJ cord-015306-us58wwmp 436 8 cases case NNS cord-015306-us58wwmp 436 9 , , , cord-015306-us58wwmp 436 10 this this DT cord-015306-us58wwmp 436 11 voided void VBN cord-015306-us58wwmp 436 12 value value NN cord-015306-us58wwmp 436 13 had have VBD cord-015306-us58wwmp 436 14 no no DT cord-015306-us58wwmp 436 15 correlation correlation NN cord-015306-us58wwmp 436 16 with with IN cord-015306-us58wwmp 436 17 clinical clinical JJ cord-015306-us58wwmp 436 18 outcome outcome NN cord-015306-us58wwmp 436 19 . . . cord-015306-us58wwmp 437 1 Conclusion conclusion NN cord-015306-us58wwmp 437 2 : : : cord-015306-us58wwmp 438 1 Bladder bladder NN cord-015306-us58wwmp 438 2 volume volume NN cord-015306-us58wwmp 438 3 can can MD cord-015306-us58wwmp 438 4 be be VB cord-015306-us58wwmp 438 5 estimated estimate VBN cord-015306-us58wwmp 438 6 in in IN cord-015306-us58wwmp 438 7 several several JJ cord-015306-us58wwmp 438 8 ways way NNS cord-015306-us58wwmp 438 9 , , , cord-015306-us58wwmp 438 10 each each DT cord-015306-us58wwmp 438 11 with with IN cord-015306-us58wwmp 438 12 their -PRON- PRP$ cord-015306-us58wwmp 438 13 advantages advantage NNS cord-015306-us58wwmp 438 14 and and CC cord-015306-us58wwmp 438 15 pitfalls pitfall NNS cord-015306-us58wwmp 438 16 . . . cord-015306-us58wwmp 439 1 Our -PRON- PRP$ cord-015306-us58wwmp 439 2 data datum NNS cord-015306-us58wwmp 439 3 demonstrate demonstrate VBP cord-015306-us58wwmp 439 4 that that IN cord-015306-us58wwmp 439 5 the the DT cord-015306-us58wwmp 439 6 alternative alternative JJ cord-015306-us58wwmp 439 7 non non FW cord-015306-us58wwmp 439 8 invasive invasive JJ cord-015306-us58wwmp 439 9 methods method NNS cord-015306-us58wwmp 439 10 during during IN cord-015306-us58wwmp 439 11 force force NN cord-015306-us58wwmp 439 12 diuresis diuresis NN cord-015306-us58wwmp 439 13 and and CC cord-015306-us58wwmp 439 14 in in IN cord-015306-us58wwmp 439 15 center center NN cord-015306-us58wwmp 439 16 during during IN cord-015306-us58wwmp 439 17 3 3 CD cord-015306-us58wwmp 439 18 uroflow uroflow NN cord-015306-us58wwmp 439 19 correlate correlate VBP cord-015306-us58wwmp 439 20 best best RB cord-015306-us58wwmp 439 21 to to IN cord-015306-us58wwmp 439 22 each each DT cord-015306-us58wwmp 439 23 other other JJ cord-015306-us58wwmp 439 24 and and CC cord-015306-us58wwmp 439 25 to to IN cord-015306-us58wwmp 439 26 the the DT cord-015306-us58wwmp 439 27 cystomanometricvalues cystomanometricvalue NNS cord-015306-us58wwmp 439 28 . . . cord-015306-us58wwmp 440 1 But but CC cord-015306-us58wwmp 440 2 as as RB cord-015306-us58wwmp 440 3 well well RB cord-015306-us58wwmp 440 4 to to IN cord-015306-us58wwmp 440 5 the the DT cord-015306-us58wwmp 440 6 one one CD cord-015306-us58wwmp 440 7 year year NN cord-015306-us58wwmp 440 8 outcome outcome NN cord-015306-us58wwmp 440 9 ( ( -LRB- cord-015306-us58wwmp 440 10 p p NN cord-015306-us58wwmp 440 11 0.04 0.04 CD cord-015306-us58wwmp 440 12 ) ) -RRB- cord-015306-us58wwmp 440 13 . . . cord-015306-us58wwmp 441 1 Abstract abstract JJ cord-015306-us58wwmp 441 2 # # NN cord-015306-us58wwmp 441 3 P p NN cord-015306-us58wwmp 441 4 - - HYPH cord-015306-us58wwmp 441 5 SAT060 SAT060 NNP cord-015306-us58wwmp 442 1 Evaluating evaluate VBG cord-015306-us58wwmp 442 2 nocturnal nocturnal JJ cord-015306-us58wwmp 442 3 diuresis diuresis NN cord-015306-us58wwmp 442 4 ( ( -LRB- cord-015306-us58wwmp 442 5 polyuria polyuria NN cord-015306-us58wwmp 442 6 ) ) -RRB- cord-015306-us58wwmp 443 1 Claire Claire NNP cord-015306-us58wwmp 443 2 DeBusschere DeBusschere NNP cord-015306-us58wwmp 443 3 , , , cord-015306-us58wwmp 443 4 Delphine Delphine NNP cord-015306-us58wwmp 443 5 Guenter Guenter NNP cord-015306-us58wwmp 443 6 , , , cord-015306-us58wwmp 443 7 Sophie Sophie NNP cord-015306-us58wwmp 443 8 Wouters Wouters NNP cord-015306-us58wwmp 443 9 , , , cord-015306-us58wwmp 443 10 Johan Johan NNP cord-015306-us58wwmp 443 11 VandeWalle VandeWalle NNP cord-015306-us58wwmp 443 12 , , , cord-015306-us58wwmp 443 13 Ann Ann NNP cord-015306-us58wwmp 443 14 Raes Raes NNP cord-015306-us58wwmp 443 15 , , , cord-015306-us58wwmp 443 16 Joke Joke NNP cord-015306-us58wwmp 443 17 Dehoorne Dehoorne NNP cord-015306-us58wwmp 443 18 Pediatric Pediatric NNP cord-015306-us58wwmp 443 19 , , , cord-015306-us58wwmp 443 20 Nephrology Nephrology NNP cord-015306-us58wwmp 443 21 , , , cord-015306-us58wwmp 443 22 Gent Gent NNP cord-015306-us58wwmp 443 23 , , , cord-015306-us58wwmp 443 24 Belgium Belgium NNP cord-015306-us58wwmp 443 25 Objective Objective NNP cord-015306-us58wwmp 443 26 : : : cord-015306-us58wwmp 443 27 Nocturnal nocturnal JJ cord-015306-us58wwmp 443 28 enuresis enuresis NN cord-015306-us58wwmp 443 29 is be VBZ cord-015306-us58wwmp 443 30 more more JJR cord-015306-us58wwmp 443 31 than than IN cord-015306-us58wwmp 443 32 bedwetting bedwette VBG cord-015306-us58wwmp 443 33 , , , cord-015306-us58wwmp 443 34 but but CC cord-015306-us58wwmp 443 35 a a DT cord-015306-us58wwmp 443 36 symptom symptom NN cord-015306-us58wwmp 443 37 of of IN cord-015306-us58wwmp 443 38 a a DT cord-015306-us58wwmp 443 39 disorder disorder NN cord-015306-us58wwmp 443 40 involving involve VBG cord-015306-us58wwmp 443 41 multiple multiple JJ cord-015306-us58wwmp 443 42 pathogenetic pathogenetic JJ cord-015306-us58wwmp 443 43 factors factor NNS cord-015306-us58wwmp 443 44 in in IN cord-015306-us58wwmp 443 45 circadian circadian JJ cord-015306-us58wwmp 443 46 rhythm rhythm NN cord-015306-us58wwmp 443 47 of of IN cord-015306-us58wwmp 443 48 diuresis diuresis NN cord-015306-us58wwmp 443 49 / / SYM cord-015306-us58wwmp 443 50 solute solute NN cord-015306-us58wwmp 443 51 excretion excretion NN cord-015306-us58wwmp 443 52 and and CC cord-015306-us58wwmp 443 53 bladder bladder NN cord-015306-us58wwmp 443 54 dysfunction dysfunction NN cord-015306-us58wwmp 443 55 . . . cord-015306-us58wwmp 444 1 Where where WRB cord-015306-us58wwmp 444 2 the the DT cord-015306-us58wwmp 444 3 sum sum NN cord-015306-us58wwmp 444 4 of of IN cord-015306-us58wwmp 444 5 diaper diaper NN cord-015306-us58wwmp 444 6 weight weight NN cord-015306-us58wwmp 444 7 and and CC cord-015306-us58wwmp 444 8 morning morning NN cord-015306-us58wwmp 444 9 voided void VBN cord-015306-us58wwmp 444 10 volume volume NN cord-015306-us58wwmp 444 11 , , , cord-015306-us58wwmp 444 12 is be VBZ cord-015306-us58wwmp 444 13 the the DT cord-015306-us58wwmp 444 14 standard standard NN cord-015306-us58wwmp 444 15 to to TO cord-015306-us58wwmp 444 16 evaluate evaluate VB cord-015306-us58wwmp 444 17 nocturnal nocturnal JJ cord-015306-us58wwmp 444 18 diuresis diuresis NN cord-015306-us58wwmp 444 19 ( ( -LRB- cord-015306-us58wwmp 444 20 polyuria polyuria NN cord-015306-us58wwmp 444 21 ) ) -RRB- cord-015306-us58wwmp 444 22 , , , cord-015306-us58wwmp 444 23 it -PRON- PRP cord-015306-us58wwmp 444 24 does do VBZ cord-015306-us58wwmp 444 25 not not RB cord-015306-us58wwmp 444 26 give give VB cord-015306-us58wwmp 444 27 indices index NNS cord-015306-us58wwmp 444 28 about about IN cord-015306-us58wwmp 444 29 pathophysiology pathophysiology NN cord-015306-us58wwmp 444 30 . . . cord-015306-us58wwmp 445 1 The the DT cord-015306-us58wwmp 445 2 Aarhus Aarhus NNP cord-015306-us58wwmp 445 3 concept concept NN cord-015306-us58wwmp 445 4 : : : cord-015306-us58wwmp 445 5 in in IN cord-015306-us58wwmp 445 6 center center NN cord-015306-us58wwmp 445 7 studies study NNS cord-015306-us58wwmp 445 8 during during IN cord-015306-us58wwmp 445 9 standardised standardised JJ cord-015306-us58wwmp 445 10 intake intake NN cord-015306-us58wwmp 445 11 , , , cord-015306-us58wwmp 445 12 offers offer VBZ cord-015306-us58wwmp 445 13 the the DT cord-015306-us58wwmp 445 14 advantage advantage NN cord-015306-us58wwmp 445 15 of of IN cord-015306-us58wwmp 445 16 standardized standardized JJ cord-015306-us58wwmp 445 17 conditions condition NNS cord-015306-us58wwmp 445 18 , , , cord-015306-us58wwmp 445 19 and and CC cord-015306-us58wwmp 445 20 reliability reliability NN cord-015306-us58wwmp 445 21 of of IN cord-015306-us58wwmp 445 22 the the DT cord-015306-us58wwmp 445 23 values value NNS cord-015306-us58wwmp 445 24 , , , cord-015306-us58wwmp 445 25 but but CC cord-015306-us58wwmp 445 26 is be VBZ cord-015306-us58wwmp 445 27 restricted restrict VBN cord-015306-us58wwmp 445 28 to to IN cord-015306-us58wwmp 445 29 specific specific JJ cord-015306-us58wwmp 445 30 research research NN cord-015306-us58wwmp 445 31 centres centre NNS cord-015306-us58wwmp 445 32 in in IN cord-015306-us58wwmp 445 33 limited limited JJ cord-015306-us58wwmp 445 34 patients patient NNS cord-015306-us58wwmp 445 35 for for IN cord-015306-us58wwmp 445 36 budgetary budgetary JJ cord-015306-us58wwmp 445 37 reasons reason NNS cord-015306-us58wwmp 445 38 ) ) -RRB- cord-015306-us58wwmp 445 39 . . . cord-015306-us58wwmp 446 1 The the DT cord-015306-us58wwmp 446 2 Ghent Ghent NNP cord-015306-us58wwmp 446 3 concept concept NN cord-015306-us58wwmp 446 4 : : : cord-015306-us58wwmp 446 5 A a DT cord-015306-us58wwmp 446 6 home home NN cord-015306-us58wwmp 446 7 based base VBN cord-015306-us58wwmp 446 8 24 24 CD cord-015306-us58wwmp 446 9 hours hour NNS cord-015306-us58wwmp 446 10 concentration concentration NN cord-015306-us58wwmp 446 11 prophyle prophyle NN cord-015306-us58wwmp 446 12 with with IN cord-015306-us58wwmp 446 13 4 4 CD cord-015306-us58wwmp 446 14 time time NN cord-015306-us58wwmp 446 15 daytime daytime NN cord-015306-us58wwmp 446 16 and and CC cord-015306-us58wwmp 446 17 4 4 CD cord-015306-us58wwmp 446 18 nighttime nighttime JJ cord-015306-us58wwmp 446 19 collections collection NNS cord-015306-us58wwmp 446 20 offers offer VBZ cord-015306-us58wwmp 446 21 an an DT cord-015306-us58wwmp 446 22 alternative alternative NN cord-015306-us58wwmp 446 23 . . . cord-015306-us58wwmp 447 1 This this DT cord-015306-us58wwmp 447 2 one one CD cord-015306-us58wwmp 447 3 day day NN cord-015306-us58wwmp 447 4 test test NN cord-015306-us58wwmp 447 5 was be VBD cord-015306-us58wwmp 447 6 not not RB cord-015306-us58wwmp 447 7 validated validate VBN cord-015306-us58wwmp 447 8 against against IN cord-015306-us58wwmp 447 9 14 14 CD cord-015306-us58wwmp 447 10 days day NNS cord-015306-us58wwmp 447 11 diuresis diuresis NN cord-015306-us58wwmp 447 12 nighttime nighttime JJ cord-015306-us58wwmp 447 13 registration registration NN cord-015306-us58wwmp 447 14 , , , cord-015306-us58wwmp 447 15 and and CC cord-015306-us58wwmp 447 16 was be VBD cord-015306-us58wwmp 447 17 criticized criticize VBN cord-015306-us58wwmp 447 18 since since IN cord-015306-us58wwmp 447 19 waking wake VBG cord-015306-us58wwmp 447 20 up up RP cord-015306-us58wwmp 447 21 the the DT cord-015306-us58wwmp 447 22 patient patient NN cord-015306-us58wwmp 447 23 overnight overnight RB cord-015306-us58wwmp 447 24 might may MD cord-015306-us58wwmp 447 25 increase increase VB cord-015306-us58wwmp 447 26 diuresis diuresis NN cord-015306-us58wwmp 447 27 and and CC cord-015306-us58wwmp 447 28 solute solute NN cord-015306-us58wwmp 447 29 excretion excretion NN cord-015306-us58wwmp 447 30 , , , cord-015306-us58wwmp 447 31 as as IN cord-015306-us58wwmp 447 32 is be VBZ cord-015306-us58wwmp 447 33 demonstrated demonstrate VBN cord-015306-us58wwmp 447 34 in in IN cord-015306-us58wwmp 447 35 sleep sleep NN cord-015306-us58wwmp 447 36 deprivation deprivation NN cord-015306-us58wwmp 447 37 Aim Aim NNP cord-015306-us58wwmp 447 38 of of IN cord-015306-us58wwmp 447 39 the the DT cord-015306-us58wwmp 447 40 study study NN cord-015306-us58wwmp 447 41 : : : cord-015306-us58wwmp 447 42 to to TO cord-015306-us58wwmp 447 43 validate validate VB cord-015306-us58wwmp 447 44 nocturnal nocturnal JJ cord-015306-us58wwmp 447 45 diuresis diuresis NN cord-015306-us58wwmp 447 46 and and CC cord-015306-us58wwmp 447 47 solution solution NN cord-015306-us58wwmp 447 48 excretion excretion NN cord-015306-us58wwmp 447 49 to to TO cord-015306-us58wwmp 447 50 evaluate evaluate VB cord-015306-us58wwmp 447 51 nocturnal nocturnal JJ cord-015306-us58wwmp 447 52 polyuria polyuria NN cord-015306-us58wwmp 447 53 against against IN cord-015306-us58wwmp 447 54 14 14 CD cord-015306-us58wwmp 447 55 days day NNS cord-015306-us58wwmp 447 56 nighttime nighttime JJ cord-015306-us58wwmp 447 57 diary diary NN cord-015306-us58wwmp 447 58 and and CC cord-015306-us58wwmp 447 59 2 2 CD cord-015306-us58wwmp 447 60 days day NNS cord-015306-us58wwmp 447 61 daytime daytime JJ cord-015306-us58wwmp 447 62 diary diary NN cord-015306-us58wwmp 447 63 . . . cord-015306-us58wwmp 448 1 Methods method NNS cord-015306-us58wwmp 448 2 : : : cord-015306-us58wwmp 449 1 To to IN cord-015306-us58wwmp 449 2 the the DT cord-015306-us58wwmp 449 3 study study NN cord-015306-us58wwmp 449 4 the the DT cord-015306-us58wwmp 449 5 incidence incidence NN cord-015306-us58wwmp 449 6 of of IN cord-015306-us58wwmp 449 7 nocturnal nocturnal JJ cord-015306-us58wwmp 449 8 polyuria polyuria NN cord-015306-us58wwmp 449 9 , , , cord-015306-us58wwmp 449 10 and and CC cord-015306-us58wwmp 449 11 to to TO cord-015306-us58wwmp 449 12 evaluate evaluate VB cord-015306-us58wwmp 449 13 the the DT cord-015306-us58wwmp 449 14 value value NN cord-015306-us58wwmp 449 15 of of IN cord-015306-us58wwmp 449 16 the the DT cord-015306-us58wwmp 449 17 morning morning NN cord-015306-us58wwmp 449 18 osmolality osmolality NN cord-015306-us58wwmp 449 19 in in IN cord-015306-us58wwmp 449 20 the the DT cord-015306-us58wwmp 449 21 study study NN cord-015306-us58wwmp 449 22 of of IN cord-015306-us58wwmp 449 23 nocturnal nocturnal JJ cord-015306-us58wwmp 449 24 polyuria polyuria NN cord-015306-us58wwmp 449 25 . . . cord-015306-us58wwmp 450 1 Results result NNS cord-015306-us58wwmp 450 2 and and CC cord-015306-us58wwmp 450 3 Conclusion conclusion NN cord-015306-us58wwmp 450 4 : : : cord-015306-us58wwmp 450 5 401 401 CD cord-015306-us58wwmp 450 6 children child NNS cord-015306-us58wwmp 450 7 ( ( -LRB- cord-015306-us58wwmp 450 8 262 262 CD cord-015306-us58wwmp 450 9 M M NNP cord-015306-us58wwmp 450 10 ) ) -RRB- cord-015306-us58wwmp 450 11 , , , cord-015306-us58wwmp 450 12 mean mean VBP cord-015306-us58wwmp 450 13 age age NN cord-015306-us58wwmp 450 14 8 8 CD cord-015306-us58wwmp 450 15 y y NN cord-015306-us58wwmp 450 16 ( ( -LRB- cord-015306-us58wwmp 450 17 5 5 CD cord-015306-us58wwmp 450 18 - - SYM cord-015306-us58wwmp 450 19 18y 18y CD cord-015306-us58wwmp 450 20 ) ) -RRB- cord-015306-us58wwmp 450 21 , , , cord-015306-us58wwmp 450 22 24 24 CD cord-015306-us58wwmp 450 23 h h NN cord-015306-us58wwmp 450 24 diuresis diuresis NN cord-015306-us58wwmp 450 25 1023+/−445 1023+/−445 CD cord-015306-us58wwmp 450 26 ml ml NNS cord-015306-us58wwmp 450 27 , , , cord-015306-us58wwmp 450 28 daytime daytime JJ cord-015306-us58wwmp 450 29 663+/−367 663+/−367 NN cord-015306-us58wwmp 450 30 ml ml NN cord-015306-us58wwmp 450 31 nighttime nighttime JJ cord-015306-us58wwmp 450 32 365+/−203ml 365+/−203ml NNS cord-015306-us58wwmp 450 33 , , , cord-015306-us58wwmp 450 34 No no DT cord-015306-us58wwmp 450 35 sex sex NN cord-015306-us58wwmp 450 36 difference difference NN cord-015306-us58wwmp 450 37 . . . cord-015306-us58wwmp 451 1 Correlation correlation NN cord-015306-us58wwmp 451 2 between between IN cord-015306-us58wwmp 451 3 volumes volume NNS cord-015306-us58wwmp 451 4 in in IN cord-015306-us58wwmp 451 5 diary diary NN cord-015306-us58wwmp 451 6 and and CC cord-015306-us58wwmp 451 7 24 24 CD cord-015306-us58wwmp 451 8 h h NN cord-015306-us58wwmp 451 9 concentration concentration NN cord-015306-us58wwmp 451 10 prophyle prophyle NN cord-015306-us58wwmp 451 11 during during IN cord-015306-us58wwmp 451 12 24 24 CD cord-015306-us58wwmp 451 13 h h NN cord-015306-us58wwmp 451 14 ( ( -LRB- cord-015306-us58wwmp 451 15 p p NN cord-015306-us58wwmp 451 16 0.036 0.036 CD cord-015306-us58wwmp 451 17 ) ) -RRB- cord-015306-us58wwmp 451 18 , , , cord-015306-us58wwmp 451 19 night night NN cord-015306-us58wwmp 451 20 ( ( -LRB- cord-015306-us58wwmp 451 21 r r NN cord-015306-us58wwmp 451 22 2 2 CD cord-015306-us58wwmp 451 23 0.336 0.336 CD cord-015306-us58wwmp 451 24 p p NN cord-015306-us58wwmp 451 25 0.013 0.013 CD cord-015306-us58wwmp 451 26 ) ) -RRB- cord-015306-us58wwmp 451 27 and and CC cord-015306-us58wwmp 451 28 day day NN cord-015306-us58wwmp 451 29 ( ( -LRB- cord-015306-us58wwmp 451 30 p p NN cord-015306-us58wwmp 451 31 0.012 0.012 CD cord-015306-us58wwmp 451 32 ) ) -RRB- cord-015306-us58wwmp 451 33 . . . cord-015306-us58wwmp 452 1 Only only RB cord-015306-us58wwmp 452 2 13 13 CD cord-015306-us58wwmp 452 3 % % NN cord-015306-us58wwmp 452 4 of of IN cord-015306-us58wwmp 452 5 patients patient NNS cord-015306-us58wwmp 452 6 have have VBP cord-015306-us58wwmp 452 7 a a DT cord-015306-us58wwmp 452 8 nocturnal nocturnal JJ cord-015306-us58wwmp 452 9 polyuria polyuria NN cord-015306-us58wwmp 452 10 ( ( -LRB- cord-015306-us58wwmp 452 11 & & CC cord-015306-us58wwmp 452 12 gt;130%EBV= gt;130%EBV= NNP cord-015306-us58wwmp 452 13 absolute absolute JJ cord-015306-us58wwmp 452 14 nocturnal nocturnal JJ cord-015306-us58wwmp 452 15 polyuria polyuria NN cord-015306-us58wwmp 452 16 ) ) -RRB- cord-015306-us58wwmp 452 17 , , , cord-015306-us58wwmp 452 18 but but CC cord-015306-us58wwmp 452 19 up up IN cord-015306-us58wwmp 452 20 to to TO cord-015306-us58wwmp 452 21 28 28 CD cord-015306-us58wwmp 452 22 % % NN cord-015306-us58wwmp 452 23 have have VBP cord-015306-us58wwmp 452 24 a a DT cord-015306-us58wwmp 452 25 nocturnal nocturnal JJ cord-015306-us58wwmp 452 26 diuresis diuresis NN cord-015306-us58wwmp 452 27 higher high JJR cord-015306-us58wwmp 452 28 than than IN cord-015306-us58wwmp 452 29 100 100 CD cord-015306-us58wwmp 452 30 % % NN cord-015306-us58wwmp 452 31 EBV EBV NNP cord-015306-us58wwmp 452 32 and and CC cord-015306-us58wwmp 452 33 & & CC cord-015306-us58wwmp 452 34 gt gt NNP cord-015306-us58wwmp 452 35 ; ; : cord-015306-us58wwmp 452 36 than than IN cord-015306-us58wwmp 452 37 their -PRON- PRP$ cord-015306-us58wwmp 452 38 MVV MVV NNP cord-015306-us58wwmp 452 39 ( ( -LRB- cord-015306-us58wwmp 452 40 relative relative JJ cord-015306-us58wwmp 452 41 polyuria polyuria NN cord-015306-us58wwmp 452 42 ) ) -RRB- cord-015306-us58wwmp 452 43 . . . cord-015306-us58wwmp 453 1 There there EX cord-015306-us58wwmp 453 2 is be VBZ cord-015306-us58wwmp 453 3 no no DT cord-015306-us58wwmp 453 4 correlation correlation NN cord-015306-us58wwmp 453 5 between between IN cord-015306-us58wwmp 453 6 early early JJ cord-015306-us58wwmp 453 7 morning morning NN cord-015306-us58wwmp 453 8 osmolality osmolality NN cord-015306-us58wwmp 453 9 and and CC cord-015306-us58wwmp 453 10 nocturnal nocturnal JJ cord-015306-us58wwmp 453 11 diuresis diuresis NN cord-015306-us58wwmp 453 12 - - HYPH cord-015306-us58wwmp 453 13 rate rate NN cord-015306-us58wwmp 453 14 ( ( -LRB- cord-015306-us58wwmp 453 15 nocturnal nocturnal JJ cord-015306-us58wwmp 453 16 polyuria polyuria NN cord-015306-us58wwmp 453 17 ) ) -RRB- cord-015306-us58wwmp 453 18 . . . cord-015306-us58wwmp 454 1 Objectives objective NNS cord-015306-us58wwmp 454 2 , , , cord-015306-us58wwmp 454 3 Methods Methods NNPS cord-015306-us58wwmp 454 4 and and CC cord-015306-us58wwmp 454 5 Results result NNS cord-015306-us58wwmp 454 6 : : : cord-015306-us58wwmp 454 7 We -PRON- PRP cord-015306-us58wwmp 454 8 present present VBP cord-015306-us58wwmp 454 9 a a DT cord-015306-us58wwmp 454 10 16 16 CD cord-015306-us58wwmp 454 11 months month NNS cord-015306-us58wwmp 454 12 old old JJ cord-015306-us58wwmp 454 13 albanian albanian JJ cord-015306-us58wwmp 454 14 female female NN cord-015306-us58wwmp 454 15 with with IN cord-015306-us58wwmp 454 16 fever fever NN cord-015306-us58wwmp 454 17 , , , cord-015306-us58wwmp 454 18 urinary urinary JJ cord-015306-us58wwmp 454 19 retention retention NN cord-015306-us58wwmp 454 20 and and CC cord-015306-us58wwmp 454 21 constipation constipation NN cord-015306-us58wwmp 454 22 . . . cord-015306-us58wwmp 455 1 This this DT cord-015306-us58wwmp 455 2 problems problem NNS cord-015306-us58wwmp 455 3 has have VBZ cord-015306-us58wwmp 455 4 occurred occur VBN cord-015306-us58wwmp 455 5 one one CD cord-015306-us58wwmp 455 6 week week NN cord-015306-us58wwmp 455 7 before before IN cord-015306-us58wwmp 455 8 hospitalization hospitalization NN cord-015306-us58wwmp 455 9 . . . cord-015306-us58wwmp 456 1 No no DT cord-015306-us58wwmp 456 2 history history NN cord-015306-us58wwmp 456 3 of of IN cord-015306-us58wwmp 456 4 trauma trauma NN cord-015306-us58wwmp 456 5 . . . cord-015306-us58wwmp 457 1 Life life NN cord-015306-us58wwmp 457 2 history history NN cord-015306-us58wwmp 457 3 has have VBZ cord-015306-us58wwmp 457 4 no no DT cord-015306-us58wwmp 457 5 remarkable remarkable JJ cord-015306-us58wwmp 457 6 data datum NNS cord-015306-us58wwmp 457 7 . . . cord-015306-us58wwmp 458 1 No no DT cord-015306-us58wwmp 458 2 history history NN cord-015306-us58wwmp 458 3 of of IN cord-015306-us58wwmp 458 4 UTI UTI NNP cord-015306-us58wwmp 458 5 or or CC cord-015306-us58wwmp 458 6 constipation constipation NN cord-015306-us58wwmp 458 7 before before RB cord-015306-us58wwmp 458 8 . . . cord-015306-us58wwmp 459 1 Physical physical JJ cord-015306-us58wwmp 459 2 examination examination NN cord-015306-us58wwmp 459 3 : : : cord-015306-us58wwmp 460 1 weight weight NN cord-015306-us58wwmp 460 2 and and CC cord-015306-us58wwmp 460 3 stature stature NN cord-015306-us58wwmp 460 4 on on IN cord-015306-us58wwmp 460 5 50 50 CD cord-015306-us58wwmp 460 6 centile centile NN cord-015306-us58wwmp 460 7 . . . cord-015306-us58wwmp 461 1 No no DT cord-015306-us58wwmp 461 2 respiratory respiratory JJ cord-015306-us58wwmp 461 3 problems problem NNS cord-015306-us58wwmp 461 4 . . . cord-015306-us58wwmp 462 1 The the DT cord-015306-us58wwmp 462 2 big big JJ cord-015306-us58wwmp 462 3 overfilled overfilled JJ cord-015306-us58wwmp 462 4 bladder bladder NN cord-015306-us58wwmp 462 5 was be VBD cord-015306-us58wwmp 462 6 palpated palpate VBN cord-015306-us58wwmp 462 7 . . . cord-015306-us58wwmp 463 1 On on IN cord-015306-us58wwmp 463 2 the the DT cord-015306-us58wwmp 463 3 left left JJ cord-015306-us58wwmp 463 4 sacral sacral JJ cord-015306-us58wwmp 463 5 region region NN cord-015306-us58wwmp 463 6 , , , cord-015306-us58wwmp 463 7 was be VBD cord-015306-us58wwmp 463 8 a a DT cord-015306-us58wwmp 463 9 tumorous tumorous JJ cord-015306-us58wwmp 463 10 mass mass NN cord-015306-us58wwmp 463 11 very very RB cord-015306-us58wwmp 463 12 painful painful JJ cord-015306-us58wwmp 463 13 and and CC cord-015306-us58wwmp 463 14 worm worm NN cord-015306-us58wwmp 463 15 . . . cord-015306-us58wwmp 464 1 Perianal Perianal NNP cord-015306-us58wwmp 464 2 reflex reflex NN cord-015306-us58wwmp 464 3 , , , cord-015306-us58wwmp 464 4 bulbocavernosus bulbocavernosus NNP cord-015306-us58wwmp 464 5 were be VBD cord-015306-us58wwmp 464 6 weak weak JJ cord-015306-us58wwmp 464 7 . . . cord-015306-us58wwmp 465 1 Other other JJ cord-015306-us58wwmp 465 2 reflexes reflex NNS cord-015306-us58wwmp 465 3 were be VBD cord-015306-us58wwmp 465 4 normal normal JJ cord-015306-us58wwmp 465 5 . . . cord-015306-us58wwmp 466 1 There there EX cord-015306-us58wwmp 466 2 were be VBD cord-015306-us58wwmp 466 3 a a DT cord-015306-us58wwmp 466 4 hard hard JJ cord-015306-us58wwmp 466 5 stools stool NNS cord-015306-us58wwmp 466 6 in in IN cord-015306-us58wwmp 466 7 the the DT cord-015306-us58wwmp 466 8 rectum rectum NN cord-015306-us58wwmp 466 9 . . . cord-015306-us58wwmp 467 1 Other other JJ cord-015306-us58wwmp 467 2 systems system NNS cord-015306-us58wwmp 467 3 examination examination NN cord-015306-us58wwmp 467 4 was be VBD cord-015306-us58wwmp 467 5 unremarkable unremarkable JJ cord-015306-us58wwmp 467 6 . . . cord-015306-us58wwmp 468 1 High high JJ cord-015306-us58wwmp 468 2 ES es NN cord-015306-us58wwmp 468 3 rate rate NN cord-015306-us58wwmp 468 4 and and CC cord-015306-us58wwmp 468 5 pathological pathological JJ cord-015306-us58wwmp 468 6 urine urine NN cord-015306-us58wwmp 468 7 sed sed NN cord-015306-us58wwmp 468 8 with with IN cord-015306-us58wwmp 468 9 infection infection NN cord-015306-us58wwmp 468 10 indicators indicator NNS cord-015306-us58wwmp 468 11 . . . cord-015306-us58wwmp 469 1 Other other JJ cord-015306-us58wwmp 469 2 Laboratory Laboratory NNP cord-015306-us58wwmp 469 3 examination examination NN cord-015306-us58wwmp 469 4 was be VBD cord-015306-us58wwmp 469 5 unremarkable unremarkable JJ cord-015306-us58wwmp 469 6 . . . cord-015306-us58wwmp 470 1 Ultrasound ultrasound NN cord-015306-us58wwmp 470 2 examination examination NN cord-015306-us58wwmp 470 3 resulted result VBD cord-015306-us58wwmp 470 4 with with IN cord-015306-us58wwmp 470 5 dilatation dilatation NN cord-015306-us58wwmp 470 6 of of IN cord-015306-us58wwmp 470 7 the the DT cord-015306-us58wwmp 470 8 left left JJ cord-015306-us58wwmp 470 9 kidney kidney NN cord-015306-us58wwmp 470 10 pyelon pyelon NNP cord-015306-us58wwmp 470 11 ( ( -LRB- cord-015306-us58wwmp 470 12 9 9 CD cord-015306-us58wwmp 470 13 mm mm NNP cord-015306-us58wwmp 470 14 ) ) -RRB- cord-015306-us58wwmp 470 15 , , , cord-015306-us58wwmp 470 16 distended distended JJ cord-015306-us58wwmp 470 17 and and CC cord-015306-us58wwmp 470 18 overfilled overfill VBN cord-015306-us58wwmp 470 19 bladder bladder NN cord-015306-us58wwmp 470 20 lumen lumen NN cord-015306-us58wwmp 470 21 ( ( -LRB- cord-015306-us58wwmp 470 22 > > XX cord-015306-us58wwmp 470 23 400ml 400ml VB cord-015306-us58wwmp 470 24 ) ) -RRB- cord-015306-us58wwmp 470 25 with with IN cord-015306-us58wwmp 470 26 thin thin JJ cord-015306-us58wwmp 470 27 bladder bladder NN cord-015306-us58wwmp 470 28 wall wall NN cord-015306-us58wwmp 470 29 . . . cord-015306-us58wwmp 471 1 Rectum rectum NN cord-015306-us58wwmp 471 2 distended distended JJ cord-015306-us58wwmp 471 3 and and CC cord-015306-us58wwmp 471 4 full full JJ cord-015306-us58wwmp 471 5 with with IN cord-015306-us58wwmp 471 6 fecal fecal JJ cord-015306-us58wwmp 471 7 masses masse NNS cord-015306-us58wwmp 471 8 . . . cord-015306-us58wwmp 472 1 Lateroposterior Lateroposterior NNP cord-015306-us58wwmp 472 2 there there EX cord-015306-us58wwmp 472 3 is be VBZ cord-015306-us58wwmp 472 4 a a DT cord-015306-us58wwmp 472 5 sonolucent sonolucent JJ cord-015306-us58wwmp 472 6 cystic cystic JJ cord-015306-us58wwmp 472 7 formation formation NN cord-015306-us58wwmp 472 8 with with IN cord-015306-us58wwmp 472 9 ( ( -LRB- cord-015306-us58wwmp 472 10 volume volume NN cord-015306-us58wwmp 472 11 7ml 7ml NNP cord-015306-us58wwmp 472 12 ) ) -RRB- cord-015306-us58wwmp 472 13 . . . cord-015306-us58wwmp 473 1 That that DT cord-015306-us58wwmp 473 2 cystic cystic JJ cord-015306-us58wwmp 473 3 formation formation NN cord-015306-us58wwmp 473 4 was be VBD cord-015306-us58wwmp 473 5 supected supecte VBN cord-015306-us58wwmp 473 6 for for IN cord-015306-us58wwmp 473 7 ureterocellae ureterocellae NNP cord-015306-us58wwmp 473 8 first first RB cord-015306-us58wwmp 473 9 . . . cord-015306-us58wwmp 474 1 The the DT cord-015306-us58wwmp 474 2 urinary urinary JJ cord-015306-us58wwmp 474 3 catheter catheter NN cord-015306-us58wwmp 474 4 and and CC cord-015306-us58wwmp 474 5 rectal rectal JJ cord-015306-us58wwmp 474 6 clismas clismas NNP cord-015306-us58wwmp 474 7 were be VBD cord-015306-us58wwmp 474 8 done do VBN cord-015306-us58wwmp 474 9 . . . cord-015306-us58wwmp 475 1 That that DT cord-015306-us58wwmp 475 2 formation formation NN cord-015306-us58wwmp 475 3 was be VBD cord-015306-us58wwmp 475 4 abscess abscess NN cord-015306-us58wwmp 475 5 and and CC cord-015306-us58wwmp 475 6 it -PRON- PRP cord-015306-us58wwmp 475 7 was be VBD cord-015306-us58wwmp 475 8 drained drain VBN cord-015306-us58wwmp 475 9 . . . cord-015306-us58wwmp 476 1 And and CC cord-015306-us58wwmp 476 2 two two CD cord-015306-us58wwmp 476 3 weeks week NNS cord-015306-us58wwmp 476 4 after after IN cord-015306-us58wwmp 476 5 was be VBD cord-015306-us58wwmp 476 6 better well JJR cord-015306-us58wwmp 476 7 . . . cord-015306-us58wwmp 477 1 Voiding void VBG cord-015306-us58wwmp 477 2 cystourethrogram cystourethrogram NNP cord-015306-us58wwmp 477 3 and and CC cord-015306-us58wwmp 477 4 Computer Computer NNP cord-015306-us58wwmp 477 5 Tomography Tomography NNP cord-015306-us58wwmp 477 6 was be VBD cord-015306-us58wwmp 477 7 done do VBN cord-015306-us58wwmp 477 8 and and CC cord-015306-us58wwmp 477 9 resulted result VBD cord-015306-us58wwmp 477 10 that that WDT cord-015306-us58wwmp 477 11 are be VBP cord-015306-us58wwmp 477 12 no no DT cord-015306-us58wwmp 477 13 anatomical anatomical JJ cord-015306-us58wwmp 477 14 defects defect NNS cord-015306-us58wwmp 477 15 in in IN cord-015306-us58wwmp 477 16 the the DT cord-015306-us58wwmp 477 17 Urinary urinary JJ cord-015306-us58wwmp 477 18 tract tract NN cord-015306-us58wwmp 477 19 . . . cord-015306-us58wwmp 478 1 Because because IN cord-015306-us58wwmp 478 2 of of IN cord-015306-us58wwmp 478 3 the the DT cord-015306-us58wwmp 478 4 collapsed collapse VBN cord-015306-us58wwmp 478 5 bowels bowel NNS cord-015306-us58wwmp 478 6 there there EX cord-015306-us58wwmp 478 7 's be VBZ cord-015306-us58wwmp 478 8 not not RB cord-015306-us58wwmp 478 9 good good JJ cord-015306-us58wwmp 478 10 visualization visualization NN cord-015306-us58wwmp 478 11 of of IN cord-015306-us58wwmp 478 12 the the DT cord-015306-us58wwmp 478 13 region region NN cord-015306-us58wwmp 478 14 around around IN cord-015306-us58wwmp 478 15 the the DT cord-015306-us58wwmp 478 16 sigma sigma NN cord-015306-us58wwmp 478 17 and and CC cord-015306-us58wwmp 478 18 rectum rectum NN cord-015306-us58wwmp 478 19 . . . cord-015306-us58wwmp 479 1 Irigografy Irigografy NNP cord-015306-us58wwmp 479 2 resulted result VBD cord-015306-us58wwmp 479 3 : : : cord-015306-us58wwmp 479 4 dolihosigma dolihosigma NNP cord-015306-us58wwmp 479 5 and and CC cord-015306-us58wwmp 479 6 suspected suspect VBN cord-015306-us58wwmp 479 7 for for IN cord-015306-us58wwmp 479 8 Hirschprung Hirschprung NNP cord-015306-us58wwmp 479 9 . . . cord-015306-us58wwmp 480 1 Two two CD cord-015306-us58wwmp 480 2 months month NNS cord-015306-us58wwmp 480 3 later later RB cord-015306-us58wwmp 480 4 the the DT cord-015306-us58wwmp 480 5 abscess abscess NN cord-015306-us58wwmp 480 6 relapsed relapse VBD cord-015306-us58wwmp 480 7 and and CC cord-015306-us58wwmp 480 8 needed need VBD cord-015306-us58wwmp 480 9 drainage drainage NN cord-015306-us58wwmp 480 10 again again RB cord-015306-us58wwmp 480 11 . . . cord-015306-us58wwmp 481 1 Conclusion conclusion NN cord-015306-us58wwmp 481 2 : : : cord-015306-us58wwmp 481 3 Since since IN cord-015306-us58wwmp 481 4 the the DT cord-015306-us58wwmp 481 5 abscess abscess NN cord-015306-us58wwmp 481 6 has have VBZ cord-015306-us58wwmp 481 7 repeated repeat VBN cord-015306-us58wwmp 481 8 the the DT cord-015306-us58wwmp 481 9 next next JJ cord-015306-us58wwmp 481 10 step step NN cord-015306-us58wwmp 481 11 will will MD cord-015306-us58wwmp 481 12 be be VB cord-015306-us58wwmp 481 13 biopsy biopsy JJ cord-015306-us58wwmp 481 14 . . . cord-015306-us58wwmp 482 1 Hirschprung Hirschprung NNP cord-015306-us58wwmp 482 2 , , , cord-015306-us58wwmp 482 3 Tailgut Tailgut NNP cord-015306-us58wwmp 482 4 cysts cyst NNS cord-015306-us58wwmp 482 5 and and CC cord-015306-us58wwmp 482 6 other other JJ cord-015306-us58wwmp 482 7 presacral presacral JJ cord-015306-us58wwmp 482 8 masses masse NNS cord-015306-us58wwmp 482 9 should should MD cord-015306-us58wwmp 482 10 be be VB cord-015306-us58wwmp 482 11 included include VBN cord-015306-us58wwmp 482 12 in in IN cord-015306-us58wwmp 482 13 the the DT cord-015306-us58wwmp 482 14 differential differential NN cord-015306-us58wwmp 482 15 for for IN cord-015306-us58wwmp 482 16 patients patient NNS cord-015306-us58wwmp 482 17 with with IN cord-015306-us58wwmp 482 18 recurrent recurrent JJ cord-015306-us58wwmp 482 19 abscess abscess NN cord-015306-us58wwmp 482 20 in in IN cord-015306-us58wwmp 482 21 the the DT cord-015306-us58wwmp 482 22 perisacral perisacral JJ cord-015306-us58wwmp 482 23 space space NN cord-015306-us58wwmp 482 24 with with IN cord-015306-us58wwmp 482 25 clinical clinical JJ cord-015306-us58wwmp 482 26 manifestation manifestation NN cord-015306-us58wwmp 482 27 of of IN cord-015306-us58wwmp 482 28 urinary urinary JJ cord-015306-us58wwmp 482 29 retention retention NN cord-015306-us58wwmp 482 30 and and CC cord-015306-us58wwmp 482 31 constipation constipation NN cord-015306-us58wwmp 482 32 . . . cord-015306-us58wwmp 483 1 Abstract abstract JJ cord-015306-us58wwmp 483 2 # # NN cord-015306-us58wwmp 483 3 P p NN cord-015306-us58wwmp 483 4 - - HYPH cord-015306-us58wwmp 483 5 SAT062 SAT062 NNP cord-015306-us58wwmp 483 6 Treatment Treatment NNP cord-015306-us58wwmp 483 7 failure failure NN cord-015306-us58wwmp 483 8 to to IN cord-015306-us58wwmp 483 9 enuresis enuresis NN cord-015306-us58wwmp 483 10 alarms alarm NNS cord-015306-us58wwmp 483 11 : : : cord-015306-us58wwmp 483 12 Challenges challenge NNS cord-015306-us58wwmp 483 13 and and CC cord-015306-us58wwmp 483 14 factors factor NNS cord-015306-us58wwmp 483 15 influencing influence VBG cord-015306-us58wwmp 483 16 adherence adherence NN cord-015306-us58wwmp 483 17 to to IN cord-015306-us58wwmp 483 18 treatment treatment NN cord-015306-us58wwmp 483 19 Indra Indra NNP cord-015306-us58wwmp 483 20 Ganesan Ganesan NNP cord-015306-us58wwmp 483 21 1 1 CD cord-015306-us58wwmp 483 22 , , , cord-015306-us58wwmp 483 23 Jessica Jessica NNP cord-015306-us58wwmp 483 24 XJ XJ NNP cord-015306-us58wwmp 483 25 Hooi Hooi NNP cord-015306-us58wwmp 483 26 2 2 CD cord-015306-us58wwmp 483 27 , , , cord-015306-us58wwmp 483 28 Jasmine Jasmine NNP cord-015306-us58wwmp 483 29 JY JY NNP cord-015306-us58wwmp 483 30 Goh Goh NNP cord-015306-us58wwmp 483 31 2 2 CD cord-015306-us58wwmp 483 32 , , , cord-015306-us58wwmp 483 33 YH YH NNP cord-015306-us58wwmp 483 34 Ng Ng NNP cord-015306-us58wwmp 483 35 1 1 CD cord-015306-us58wwmp 483 36 , , , cord-015306-us58wwmp 483 37 SM SM NNP cord-015306-us58wwmp 483 38 Chao Chao NNP cord-015306-us58wwmp 483 39 1 1 CD cord-015306-us58wwmp 483 40 1 1 CD cord-015306-us58wwmp 483 41 Nephrology Nephrology NNP cord-015306-us58wwmp 483 42 Service Service NNP cord-015306-us58wwmp 483 43 , , , cord-015306-us58wwmp 483 44 KK KK NNP cord-015306-us58wwmp 483 45 Women Women NNP cord-015306-us58wwmp 483 46 's 's POS cord-015306-us58wwmp 483 47 and and CC cord-015306-us58wwmp 483 48 Children Children NNP cord-015306-us58wwmp 483 49 's 's POS cord-015306-us58wwmp 483 50 Hospital Hospital NNP cord-015306-us58wwmp 483 51 , , , cord-015306-us58wwmp 483 52 Singapore Singapore NNP cord-015306-us58wwmp 483 53 , , , cord-015306-us58wwmp 483 54 Singapore Singapore NNP cord-015306-us58wwmp 483 55 2 2 CD cord-015306-us58wwmp 483 56 Department Department NNP cord-015306-us58wwmp 483 57 of of IN cord-015306-us58wwmp 483 58 Pediatrics Pediatrics NNP cord-015306-us58wwmp 483 59 , , , cord-015306-us58wwmp 483 60 KK KK NNP cord-015306-us58wwmp 483 61 Women Women NNP cord-015306-us58wwmp 483 62 's 's POS cord-015306-us58wwmp 483 63 and and CC cord-015306-us58wwmp 483 64 Children Children NNP cord-015306-us58wwmp 483 65 's 's POS cord-015306-us58wwmp 483 66 Hospital Hospital NNP cord-015306-us58wwmp 483 67 , , , cord-015306-us58wwmp 483 68 Singapore Singapore NNP cord-015306-us58wwmp 483 69 , , , cord-015306-us58wwmp 484 1 Singapore Singapore NNP cord-015306-us58wwmp 484 2 Objective Objective NNP cord-015306-us58wwmp 484 3 : : : cord-015306-us58wwmp 484 4 The the DT cord-015306-us58wwmp 484 5 study study NN cord-015306-us58wwmp 484 6 aims aim VBZ cord-015306-us58wwmp 484 7 to to TO cord-015306-us58wwmp 484 8 identify identify VB cord-015306-us58wwmp 484 9 factors factor NNS cord-015306-us58wwmp 484 10 influencing influence VBG cord-015306-us58wwmp 484 11 treatment treatment NN cord-015306-us58wwmp 484 12 failure failure NN cord-015306-us58wwmp 484 13 to to IN cord-015306-us58wwmp 484 14 enuresis enuresis NN cord-015306-us58wwmp 484 15 alarm alarm NN cord-015306-us58wwmp 484 16 and and CC cord-015306-us58wwmp 484 17 the the DT cord-015306-us58wwmp 484 18 factors factor NNS cord-015306-us58wwmp 484 19 influencing influence VBG cord-015306-us58wwmp 484 20 adherence adherence NN cord-015306-us58wwmp 484 21 to to IN cord-015306-us58wwmp 484 22 treatment treatment NN cord-015306-us58wwmp 484 23 . . . cord-015306-us58wwmp 485 1 Methods method NNS cord-015306-us58wwmp 485 2 : : : cord-015306-us58wwmp 486 1 All all DT cord-015306-us58wwmp 486 2 patients patient NNS cord-015306-us58wwmp 486 3 aged age VBN cord-015306-us58wwmp 486 4 6 6 CD cord-015306-us58wwmp 486 5 to to TO cord-015306-us58wwmp 486 6 16 16 CD cord-015306-us58wwmp 486 7 years year NNS cord-015306-us58wwmp 486 8 referred refer VBN cord-015306-us58wwmp 486 9 to to IN cord-015306-us58wwmp 486 10 the the DT cord-015306-us58wwmp 486 11 voiding void VBG cord-015306-us58wwmp 486 12 clinic clinic NN cord-015306-us58wwmp 486 13 in in IN cord-015306-us58wwmp 486 14 KK KK NNP cord-015306-us58wwmp 486 15 Women Women NNP cord-015306-us58wwmp 486 16 's 's POS cord-015306-us58wwmp 486 17 and and CC cord-015306-us58wwmp 486 18 Children Children NNP cord-015306-us58wwmp 486 19 's 's POS cord-015306-us58wwmp 486 20 Hospital Hospital NNP cord-015306-us58wwmp 486 21 , , , cord-015306-us58wwmp 486 22 Singapore Singapore NNP cord-015306-us58wwmp 486 23 with with IN cord-015306-us58wwmp 486 24 Primary primary JJ cord-015306-us58wwmp 486 25 nocturnal nocturnal JJ cord-015306-us58wwmp 486 26 enuresis enuresis NN cord-015306-us58wwmp 486 27 who who WP cord-015306-us58wwmp 486 28 opted opt VBD cord-015306-us58wwmp 486 29 for for IN cord-015306-us58wwmp 486 30 enuresis enuresis NN cord-015306-us58wwmp 486 31 alarm alarm NN cord-015306-us58wwmp 486 32 treatment treatment NN cord-015306-us58wwmp 486 33 , , , cord-015306-us58wwmp 486 34 over over IN cord-015306-us58wwmp 486 35 6 6 CD cord-015306-us58wwmp 486 36 year year NN cord-015306-us58wwmp 486 37 period period NN cord-015306-us58wwmp 486 38 from from IN cord-015306-us58wwmp 486 39 2007 2007 CD cord-015306-us58wwmp 486 40 - - SYM cord-015306-us58wwmp 486 41 2013 2013 CD cord-015306-us58wwmp 486 42 , , , cord-015306-us58wwmp 486 43 were be VBD cord-015306-us58wwmp 486 44 prospectively prospectively RB cord-015306-us58wwmp 486 45 studied study VBN cord-015306-us58wwmp 486 46 . . . cord-015306-us58wwmp 487 1 Data datum NNS cord-015306-us58wwmp 487 2 , , , cord-015306-us58wwmp 487 3 via via IN cord-015306-us58wwmp 487 4 direct direct JJ cord-015306-us58wwmp 487 5 interview interview NN cord-015306-us58wwmp 487 6 and and CC cord-015306-us58wwmp 487 7 parental parental JJ cord-015306-us58wwmp 487 8 questionnaire questionnaire NN cord-015306-us58wwmp 487 9 was be VBD cord-015306-us58wwmp 487 10 collected collect VBN cord-015306-us58wwmp 487 11 on on IN cord-015306-us58wwmp 487 12 demographics demographic NNS cord-015306-us58wwmp 487 13 , , , cord-015306-us58wwmp 487 14 age age NN cord-015306-us58wwmp 487 15 at at IN cord-015306-us58wwmp 487 16 presentation presentation NN cord-015306-us58wwmp 487 17 , , , cord-015306-us58wwmp 487 18 presence presence NN cord-015306-us58wwmp 487 19 of of IN cord-015306-us58wwmp 487 20 family family NN cord-015306-us58wwmp 487 21 history history NN cord-015306-us58wwmp 487 22 , , , cord-015306-us58wwmp 487 23 frequency frequency NN cord-015306-us58wwmp 487 24 of of IN cord-015306-us58wwmp 487 25 nocturnal nocturnal JJ cord-015306-us58wwmp 487 26 enuresis enuresis NN cord-015306-us58wwmp 487 27 per per IN cord-015306-us58wwmp 487 28 week week NN cord-015306-us58wwmp 487 29 and and CC cord-015306-us58wwmp 487 30 per per IN cord-015306-us58wwmp 487 31 night night NN cord-015306-us58wwmp 487 32 , , , cord-015306-us58wwmp 487 33 on on IN cord-015306-us58wwmp 487 34 whether whether IN cord-015306-us58wwmp 487 35 child child NN cord-015306-us58wwmp 487 36 awakens awaken VBZ cord-015306-us58wwmp 487 37 after after IN cord-015306-us58wwmp 487 38 wetting wetting NN cord-015306-us58wwmp 487 39 , , , cord-015306-us58wwmp 487 40 or or CC cord-015306-us58wwmp 487 41 associated associate VBD cord-015306-us58wwmp 487 42 constipation constipation NN cord-015306-us58wwmp 487 43 in in IN cord-015306-us58wwmp 487 44 the the DT cord-015306-us58wwmp 487 45 child child NN cord-015306-us58wwmp 487 46 and and CC cord-015306-us58wwmp 487 47 parental parental JJ cord-015306-us58wwmp 487 48 perception perception NN cord-015306-us58wwmp 487 49 of of IN cord-015306-us58wwmp 487 50 why why WRB cord-015306-us58wwmp 487 51 primary primary JJ cord-015306-us58wwmp 487 52 enuresis enuresis NN cord-015306-us58wwmp 487 53 happens happen VBZ cord-015306-us58wwmp 487 54 . . . cord-015306-us58wwmp 488 1 Results result NNS cord-015306-us58wwmp 488 2 : : : cord-015306-us58wwmp 489 1 Seventy seventy CD cord-015306-us58wwmp 489 2 - - HYPH cord-015306-us58wwmp 489 3 nine nine CD cord-015306-us58wwmp 489 4 of of IN cord-015306-us58wwmp 489 5 111 111 CD cord-015306-us58wwmp 489 6 ( ( -LRB- cord-015306-us58wwmp 489 7 71 71 CD cord-015306-us58wwmp 489 8 % % NN cord-015306-us58wwmp 489 9 ) ) -RRB- cord-015306-us58wwmp 489 10 children child NNS cord-015306-us58wwmp 489 11 with with IN cord-015306-us58wwmp 489 12 primary primary JJ cord-015306-us58wwmp 489 13 nocturnal nocturnal JJ cord-015306-us58wwmp 489 14 enuresis enuresis NN cord-015306-us58wwmp 489 15 with with IN cord-015306-us58wwmp 489 16 complete complete JJ cord-015306-us58wwmp 489 17 data datum NNS cord-015306-us58wwmp 489 18 were be VBD cord-015306-us58wwmp 489 19 included include VBN cord-015306-us58wwmp 489 20 . . . cord-015306-us58wwmp 490 1 Mean mean JJ cord-015306-us58wwmp 490 2 age age NN cord-015306-us58wwmp 490 3 at at IN cord-015306-us58wwmp 490 4 presentation presentation NN cord-015306-us58wwmp 490 5 was be VBD cord-015306-us58wwmp 490 6 9.6±2.1 9.6±2.1 CD cord-015306-us58wwmp 490 7 years year NNS cord-015306-us58wwmp 490 8 and and CC cord-015306-us58wwmp 490 9 45 45 CD cord-015306-us58wwmp 490 10 ( ( -LRB- cord-015306-us58wwmp 490 11 57 57 CD cord-015306-us58wwmp 490 12 % % NN cord-015306-us58wwmp 490 13 ) ) -RRB- cord-015306-us58wwmp 490 14 were be VBD cord-015306-us58wwmp 490 15 male male JJ cord-015306-us58wwmp 490 16 . . . cord-015306-us58wwmp 491 1 Twenty twenty CD cord-015306-us58wwmp 491 2 - - HYPH cord-015306-us58wwmp 491 3 five five CD cord-015306-us58wwmp 491 4 children child NNS cord-015306-us58wwmp 491 5 had have VBD cord-015306-us58wwmp 491 6 a a DT cord-015306-us58wwmp 491 7 family family NN cord-015306-us58wwmp 491 8 history history NN cord-015306-us58wwmp 491 9 of of IN cord-015306-us58wwmp 491 10 nocturnal nocturnal JJ cord-015306-us58wwmp 491 11 enuresis enuresis NN cord-015306-us58wwmp 491 12 in in IN cord-015306-us58wwmp 491 13 a a DT cord-015306-us58wwmp 491 14 1 1 CD cord-015306-us58wwmp 491 15 st st NNP cord-015306-us58wwmp 491 16 degree degree NN cord-015306-us58wwmp 491 17 relative relative NN cord-015306-us58wwmp 491 18 . . . cord-015306-us58wwmp 492 1 Eighteen eighteen CD cord-015306-us58wwmp 492 2 children child NNS cord-015306-us58wwmp 492 3 had have VBD cord-015306-us58wwmp 492 4 constipation constipation NN cord-015306-us58wwmp 492 5 . . . cord-015306-us58wwmp 493 1 Fifty fifty CD cord-015306-us58wwmp 493 2 - - HYPH cord-015306-us58wwmp 493 3 one one CD cord-015306-us58wwmp 493 4 ( ( -LRB- cord-015306-us58wwmp 493 5 64 64 CD cord-015306-us58wwmp 493 6 % % NN cord-015306-us58wwmp 493 7 ) ) -RRB- cord-015306-us58wwmp 494 1 children child NNS cord-015306-us58wwmp 494 2 achieved achieve VBD cord-015306-us58wwmp 494 3 the the DT cord-015306-us58wwmp 494 4 targeted target VBN cord-015306-us58wwmp 494 5 21 21 CD cord-015306-us58wwmp 494 6 consecutive consecutive JJ cord-015306-us58wwmp 494 7 dry dry JJ cord-015306-us58wwmp 494 8 nights night NNS cord-015306-us58wwmp 494 9 . . . cord-015306-us58wwmp 495 1 In in IN cord-015306-us58wwmp 495 2 the the DT cord-015306-us58wwmp 495 3 remaining remain VBG cord-015306-us58wwmp 495 4 28 28 CD cord-015306-us58wwmp 495 5 children child NNS cord-015306-us58wwmp 495 6 , , , cord-015306-us58wwmp 495 7 the the DT cord-015306-us58wwmp 495 8 main main JJ cord-015306-us58wwmp 495 9 reasons reason NNS cord-015306-us58wwmp 495 10 for for IN cord-015306-us58wwmp 495 11 treatment treatment NN cord-015306-us58wwmp 495 12 failure failure NN cord-015306-us58wwmp 495 13 were be VBD cord-015306-us58wwmp 495 14 non non JJ cord-015306-us58wwmp 495 15 adherence adherence NN cord-015306-us58wwmp 495 16 to to IN cord-015306-us58wwmp 495 17 usage usage NN cord-015306-us58wwmp 495 18 of of IN cord-015306-us58wwmp 495 19 enuresis enuresis NN cord-015306-us58wwmp 495 20 alarms alarm NNS cord-015306-us58wwmp 495 21 mainly mainly RB cord-015306-us58wwmp 495 22 due due IN cord-015306-us58wwmp 495 23 to to IN cord-015306-us58wwmp 495 24 an an DT cord-015306-us58wwmp 495 25 inability inability NN cord-015306-us58wwmp 495 26 to to TO cord-015306-us58wwmp 495 27 wake wake VB cord-015306-us58wwmp 495 28 up up RP cord-015306-us58wwmp 495 29 to to IN cord-015306-us58wwmp 495 30 the the DT cord-015306-us58wwmp 495 31 alarm alarm NN cord-015306-us58wwmp 495 32 in in IN cord-015306-us58wwmp 495 33 deep deep JJ cord-015306-us58wwmp 495 34 sleep sleep NN cord-015306-us58wwmp 495 35 ( ( -LRB- cord-015306-us58wwmp 495 36 71 71 CD cord-015306-us58wwmp 495 37 % % NN cord-015306-us58wwmp 495 38 ) ) -RRB- cord-015306-us58wwmp 495 39 and and CC cord-015306-us58wwmp 495 40 underlying underlie VBG cord-015306-us58wwmp 495 41 neurobehavioural neurobehavioural JJ cord-015306-us58wwmp 495 42 conditions condition NNS cord-015306-us58wwmp 495 43 ( ( -LRB- cord-015306-us58wwmp 495 44 21 21 CD cord-015306-us58wwmp 495 45 % % NN cord-015306-us58wwmp 495 46 ) ) -RRB- cord-015306-us58wwmp 495 47 ( ( -LRB- cord-015306-us58wwmp 495 48 ADHD ADHD NNP cord-015306-us58wwmp 495 49 , , , cord-015306-us58wwmp 495 50 autism autism NN cord-015306-us58wwmp 495 51 , , , cord-015306-us58wwmp 495 52 depression depression NN cord-015306-us58wwmp 495 53 and and CC cord-015306-us58wwmp 495 54 a a DT cord-015306-us58wwmp 495 55 chromosomal chromosomal JJ cord-015306-us58wwmp 495 56 disorder disorder NN cord-015306-us58wwmp 495 57 ) ) -RRB- cord-015306-us58wwmp 495 58 . . . cord-015306-us58wwmp 496 1 The the DT cord-015306-us58wwmp 496 2 only only JJ cord-015306-us58wwmp 496 3 significant significant JJ cord-015306-us58wwmp 496 4 clinical clinical JJ cord-015306-us58wwmp 496 5 factor factor NN cord-015306-us58wwmp 496 6 predicting predict VBG cord-015306-us58wwmp 496 7 treatment treatment NN cord-015306-us58wwmp 496 8 failure failure NN cord-015306-us58wwmp 496 9 was be VBD cord-015306-us58wwmp 496 10 the the DT cord-015306-us58wwmp 496 11 presence presence NN cord-015306-us58wwmp 496 12 of of IN cord-015306-us58wwmp 496 13 an an DT cord-015306-us58wwmp 496 14 underlying underlie VBG cord-015306-us58wwmp 496 15 neurobehavioural neurobehavioural JJ cord-015306-us58wwmp 496 16 condition condition NN cord-015306-us58wwmp 496 17 ( ( -LRB- cord-015306-us58wwmp 496 18 OR or CC cord-015306-us58wwmp 496 19 2.8 2.8 CD cord-015306-us58wwmp 496 20 , , , cord-015306-us58wwmp 496 21 and and CC cord-015306-us58wwmp 496 22 developmental developmental JJ cord-015306-us58wwmp 496 23 delay delay NN cord-015306-us58wwmp 496 24 . . . cord-015306-us58wwmp 497 1 Factors factor NNS cord-015306-us58wwmp 497 2 such such JJ cord-015306-us58wwmp 497 3 as as IN cord-015306-us58wwmp 497 4 male male JJ cord-015306-us58wwmp 497 5 gender gender NN cord-015306-us58wwmp 497 6 , , , cord-015306-us58wwmp 497 7 family family NN cord-015306-us58wwmp 497 8 history history NN cord-015306-us58wwmp 497 9 in in IN cord-015306-us58wwmp 497 10 first first JJ cord-015306-us58wwmp 497 11 degree degree NN cord-015306-us58wwmp 497 12 relatives relative NNS cord-015306-us58wwmp 497 13 , , , cord-015306-us58wwmp 497 14 frequency frequency NN cord-015306-us58wwmp 497 15 of of IN cord-015306-us58wwmp 497 16 enuresis enuresis NN cord-015306-us58wwmp 497 17 , , , cord-015306-us58wwmp 497 18 arousal arousal NN cord-015306-us58wwmp 497 19 when when WRB cord-015306-us58wwmp 497 20 wet wet JJ cord-015306-us58wwmp 497 21 , , , cord-015306-us58wwmp 497 22 and and CC cord-015306-us58wwmp 497 23 the the DT cord-015306-us58wwmp 497 24 presence presence NN cord-015306-us58wwmp 497 25 of of IN cord-015306-us58wwmp 497 26 constipation constipation NN cord-015306-us58wwmp 497 27 , , , cord-015306-us58wwmp 497 28 were be VBD cord-015306-us58wwmp 497 29 not not RB cord-015306-us58wwmp 497 30 significant significant JJ cord-015306-us58wwmp 497 31 . . . cord-015306-us58wwmp 498 1 Conclusion conclusion NN cord-015306-us58wwmp 498 2 : : : cord-015306-us58wwmp 499 1 In in IN cord-015306-us58wwmp 499 2 our -PRON- PRP$ cord-015306-us58wwmp 499 3 population population NN cord-015306-us58wwmp 499 4 , , , cord-015306-us58wwmp 499 5 64 64 CD cord-015306-us58wwmp 499 6 % % NN cord-015306-us58wwmp 499 7 of of IN cord-015306-us58wwmp 499 8 children child NNS cord-015306-us58wwmp 499 9 achieved achieve VBD cord-015306-us58wwmp 499 10 nocturnal nocturnal JJ cord-015306-us58wwmp 499 11 urinary urinary JJ cord-015306-us58wwmp 499 12 continence continence NN cord-015306-us58wwmp 499 13 with with IN cord-015306-us58wwmp 499 14 enuresis enuresis NN cord-015306-us58wwmp 499 15 alarms alarm NNS cord-015306-us58wwmp 499 16 . . . cord-015306-us58wwmp 500 1 Treatment treatment NN cord-015306-us58wwmp 500 2 failure failure NN cord-015306-us58wwmp 500 3 of of IN cord-015306-us58wwmp 500 4 enuresis enuresis NN cord-015306-us58wwmp 500 5 alarms alarm NNS cord-015306-us58wwmp 500 6 is be VBZ cord-015306-us58wwmp 500 7 higher high JJR cord-015306-us58wwmp 500 8 in in IN cord-015306-us58wwmp 500 9 the the DT cord-015306-us58wwmp 500 10 presence presence NN cord-015306-us58wwmp 500 11 of of IN cord-015306-us58wwmp 500 12 an an DT cord-015306-us58wwmp 500 13 underlying underlie VBG cord-015306-us58wwmp 500 14 neurobehavioural neurobehavioural JJ cord-015306-us58wwmp 500 15 condition condition NN cord-015306-us58wwmp 500 16 and and CC cord-015306-us58wwmp 500 17 developmental developmental JJ cord-015306-us58wwmp 500 18 delay delay NN cord-015306-us58wwmp 500 19 . . . cord-015306-us58wwmp 501 1 Non non JJ cord-015306-us58wwmp 501 2 adherence adherence NN cord-015306-us58wwmp 501 3 to to IN cord-015306-us58wwmp 501 4 treatment treatment NN cord-015306-us58wwmp 501 5 is be VBZ cord-015306-us58wwmp 501 6 mainly mainly RB cord-015306-us58wwmp 501 7 due due JJ cord-015306-us58wwmp 501 8 to to IN cord-015306-us58wwmp 501 9 inability inability NN cord-015306-us58wwmp 501 10 to to TO cord-015306-us58wwmp 501 11 arouse arouse VB cord-015306-us58wwmp 501 12 from from IN cord-015306-us58wwmp 501 13 deep deep JJ cord-015306-us58wwmp 501 14 sleep sleep NN cord-015306-us58wwmp 501 15 . . . cord-015306-us58wwmp 502 1 Long long JJ cord-015306-us58wwmp 502 2 - - HYPH cord-015306-us58wwmp 502 3 term term NN cord-015306-us58wwmp 502 4 follow follow NN cord-015306-us58wwmp 502 5 - - HYPH cord-015306-us58wwmp 502 6 up up NN cord-015306-us58wwmp 502 7 of of IN cord-015306-us58wwmp 502 8 children child NNS cord-015306-us58wwmp 502 9 with with IN cord-015306-us58wwmp 502 10 nocturnal nocturnal JJ cord-015306-us58wwmp 502 11 enuresis enuresis NN cord-015306-us58wwmp 502 12 -do -do HYPH cord-015306-us58wwmp 502 13 enuretics enuretic NNS cord-015306-us58wwmp 502 14 become become VBP cord-015306-us58wwmp 502 15 nocturics nocturic NNS cord-015306-us58wwmp 502 16 ? ? . cord-015306-us58wwmp 503 1 An an LS cord-015306-us58wwmp 503 2 - - : cord-015306-us58wwmp 503 3 Sofie Sofie NNP cord-015306-us58wwmp 503 4 Goessaert Goessaert NNP cord-015306-us58wwmp 503 5 1 1 CD cord-015306-us58wwmp 503 6 , , , cord-015306-us58wwmp 503 7 Bente Bente NNP cord-015306-us58wwmp 503 8 Schoenaers Schoenaers NNP cord-015306-us58wwmp 503 9 2 2 CD cord-015306-us58wwmp 503 10 , , , cord-015306-us58wwmp 503 11 Olivier Olivier NNP cord-015306-us58wwmp 503 12 Opdenakker Opdenakker NNP cord-015306-us58wwmp 503 13 2 2 CD cord-015306-us58wwmp 503 14 , , , cord-015306-us58wwmp 503 15 Karel Karel NNP cord-015306-us58wwmp 503 16 Everaert Everaert NNP cord-015306-us58wwmp 503 17 1 1 CD cord-015306-us58wwmp 503 18 , , , cord-015306-us58wwmp 503 19 Johan Johan NNP cord-015306-us58wwmp 503 20 VandeWalle VandeWalle NNP cord-015306-us58wwmp 504 1 3 3 CD cord-015306-us58wwmp 504 2 1 1 CD cord-015306-us58wwmp 504 3 Urology Urology NNP cord-015306-us58wwmp 504 4 , , , cord-015306-us58wwmp 504 5 Ghent Ghent NNP cord-015306-us58wwmp 504 6 University University NNP cord-015306-us58wwmp 504 7 Hospital Hospital NNP cord-015306-us58wwmp 504 8 , , , cord-015306-us58wwmp 504 9 Ghent Ghent NNP cord-015306-us58wwmp 504 10 , , , cord-015306-us58wwmp 504 11 Belgium Belgium NNP cord-015306-us58wwmp 504 12 2 2 CD cord-015306-us58wwmp 504 13 Ghent Ghent NNP cord-015306-us58wwmp 504 14 University University NNP cord-015306-us58wwmp 504 15 , , , cord-015306-us58wwmp 504 16 Ghent Ghent NNP cord-015306-us58wwmp 504 17 , , , cord-015306-us58wwmp 504 18 Belgium Belgium NNP cord-015306-us58wwmp 504 19 3 3 CD cord-015306-us58wwmp 504 20 Pediatric Pediatric NNP cord-015306-us58wwmp 504 21 Nephrology Nephrology NNP cord-015306-us58wwmp 504 22 , , , cord-015306-us58wwmp 504 23 Ghent Ghent NNP cord-015306-us58wwmp 504 24 University University NNP cord-015306-us58wwmp 504 25 Hospital Hospital NNP cord-015306-us58wwmp 504 26 , , , cord-015306-us58wwmp 504 27 Ghent Ghent NNP cord-015306-us58wwmp 504 28 , , , cord-015306-us58wwmp 504 29 Belgium Belgium NNP cord-015306-us58wwmp 504 30 Objective Objective NNP cord-015306-us58wwmp 504 31 : : : cord-015306-us58wwmp 505 1 Although although IN cord-015306-us58wwmp 505 2 an an DT cord-015306-us58wwmp 505 3 overlap overlap NN cord-015306-us58wwmp 505 4 between between IN cord-015306-us58wwmp 505 5 both both DT cord-015306-us58wwmp 505 6 nocturnal nocturnal JJ cord-015306-us58wwmp 505 7 enuresis enuresis NN cord-015306-us58wwmp 505 8 ( ( -LRB- cord-015306-us58wwmp 505 9 NE NE NNP cord-015306-us58wwmp 505 10 ) ) -RRB- cord-015306-us58wwmp 505 11 and and CC cord-015306-us58wwmp 505 12 nocturia nocturia NNP cord-015306-us58wwmp 505 13 is be VBZ cord-015306-us58wwmp 505 14 known know VBN cord-015306-us58wwmp 505 15 , , , cord-015306-us58wwmp 505 16 research research NN cord-015306-us58wwmp 505 17 on on IN cord-015306-us58wwmp 505 18 the the DT cord-015306-us58wwmp 505 19 occurrence occurrence NN cord-015306-us58wwmp 505 20 of of IN cord-015306-us58wwmp 505 21 both both DT cord-015306-us58wwmp 505 22 conditions condition NNS cord-015306-us58wwmp 505 23 in in IN cord-015306-us58wwmp 505 24 one one CD cord-015306-us58wwmp 505 25 patient patient NN cord-015306-us58wwmp 505 26 is be VBZ cord-015306-us58wwmp 505 27 lacking lack VBG cord-015306-us58wwmp 505 28 . . . cord-015306-us58wwmp 506 1 This this DT cord-015306-us58wwmp 506 2 study study NN cord-015306-us58wwmp 506 3 aims aim VBZ cord-015306-us58wwmp 506 4 to to TO cord-015306-us58wwmp 506 5 investigate investigate VB cord-015306-us58wwmp 506 6 the the DT cord-015306-us58wwmp 506 7 prevalence prevalence NN cord-015306-us58wwmp 506 8 of of IN cord-015306-us58wwmp 506 9 nocturia nocturia NNS cord-015306-us58wwmp 506 10 and and CC cord-015306-us58wwmp 506 11 other other JJ cord-015306-us58wwmp 506 12 urinary urinary JJ cord-015306-us58wwmp 506 13 symptoms symptom NNS cord-015306-us58wwmp 506 14 in in IN cord-015306-us58wwmp 506 15 patients patient NNS cord-015306-us58wwmp 506 16 who who WP cord-015306-us58wwmp 506 17 have have VBP cord-015306-us58wwmp 506 18 suffered suffer VBN cord-015306-us58wwmp 506 19 from from IN cord-015306-us58wwmp 506 20 NE NE NNP cord-015306-us58wwmp 506 21 . . . cord-015306-us58wwmp 507 1 Methods method NNS cord-015306-us58wwmp 507 2 : : : cord-015306-us58wwmp 508 1 A a DT cord-015306-us58wwmp 508 2 questionnaire questionnaire NN cord-015306-us58wwmp 508 3 was be VBD cord-015306-us58wwmp 508 4 sent send VBN cord-015306-us58wwmp 508 5 to to IN cord-015306-us58wwmp 508 6 1265 1265 CD cord-015306-us58wwmp 508 7 patients patient NNS cord-015306-us58wwmp 508 8 treated treat VBD cord-015306-us58wwmp 508 9 more more JJR cord-015306-us58wwmp 508 10 than than IN cord-015306-us58wwmp 508 11 3 3 CD cord-015306-us58wwmp 508 12 years year NNS cord-015306-us58wwmp 508 13 ago ago RB cord-015306-us58wwmp 508 14 in in IN cord-015306-us58wwmp 508 15 the the DT cord-015306-us58wwmp 508 16 University University NNP cord-015306-us58wwmp 508 17 Hospital Hospital NNP cord-015306-us58wwmp 508 18 of of IN cord-015306-us58wwmp 508 19 Ghent Ghent NNP cord-015306-us58wwmp 508 20 for for IN cord-015306-us58wwmp 508 21 NE NE NNP cord-015306-us58wwmp 508 22 evaluating evaluate VBG cord-015306-us58wwmp 508 23 the the DT cord-015306-us58wwmp 508 24 history history NN cord-015306-us58wwmp 508 25 and and CC cord-015306-us58wwmp 508 26 current current JJ cord-015306-us58wwmp 508 27 status status NN cord-015306-us58wwmp 508 28 of of IN cord-015306-us58wwmp 508 29 enuresis enuresis NN cord-015306-us58wwmp 508 30 and and CC cord-015306-us58wwmp 508 31 validated validate VBD cord-015306-us58wwmp 508 32 questionnaires questionnaire NNS cord-015306-us58wwmp 508 33 on on IN cord-015306-us58wwmp 508 34 urinary urinary JJ cord-015306-us58wwmp 508 35 incontinence incontinence NN cord-015306-us58wwmp 508 36 ( ( -LRB- cord-015306-us58wwmp 508 37 ICIQ ICIQ NNP cord-015306-us58wwmp 508 38 - - HYPH cord-015306-us58wwmp 508 39 UI UI NNP cord-015306-us58wwmp 508 40 ) ) -RRB- cord-015306-us58wwmp 508 41 and and CC cord-015306-us58wwmp 508 42 overactive overactive JJ cord-015306-us58wwmp 508 43 bladder bladder NN cord-015306-us58wwmp 508 44 symptoms symptom NNS cord-015306-us58wwmp 508 45 ( ( -LRB- cord-015306-us58wwmp 508 46 ICIQ ICIQ NNP cord-015306-us58wwmp 508 47 - - HYPH cord-015306-us58wwmp 508 48 OAB OAB NNP cord-015306-us58wwmp 508 49 ) ) -RRB- cord-015306-us58wwmp 508 50 . . . cord-015306-us58wwmp 509 1 Medical medical JJ cord-015306-us58wwmp 509 2 files file NNS cord-015306-us58wwmp 509 3 of of IN cord-015306-us58wwmp 509 4 all all DT cord-015306-us58wwmp 509 5 subjects subject NNS cord-015306-us58wwmp 509 6 were be VBD cord-015306-us58wwmp 509 7 analysed analyse VBN cord-015306-us58wwmp 509 8 on on IN cord-015306-us58wwmp 509 9 the the DT cord-015306-us58wwmp 509 10 history history NN cord-015306-us58wwmp 509 11 of of IN cord-015306-us58wwmp 509 12 enuresis enuresis NN cord-015306-us58wwmp 509 13 . . . cord-015306-us58wwmp 510 1 All all DT cord-015306-us58wwmp 510 2 subjects subject NNS cord-015306-us58wwmp 510 3 were be VBD cord-015306-us58wwmp 510 4 asked ask VBN cord-015306-us58wwmp 510 5 to to TO cord-015306-us58wwmp 510 6 sign sign VB cord-015306-us58wwmp 510 7 an an DT cord-015306-us58wwmp 510 8 informed informed JJ cord-015306-us58wwmp 510 9 consent consent NN cord-015306-us58wwmp 510 10 . . . cord-015306-us58wwmp 511 1 Results result NNS cord-015306-us58wwmp 511 2 : : : cord-015306-us58wwmp 512 1 Of of IN cord-015306-us58wwmp 512 2 the the DT cord-015306-us58wwmp 512 3 516 516 CD cord-015306-us58wwmp 512 4 ( ( -LRB- cord-015306-us58wwmp 512 5 41 41 CD cord-015306-us58wwmp 512 6 % % NN cord-015306-us58wwmp 512 7 ) ) -RRB- cord-015306-us58wwmp 512 8 subjects subject NNS cord-015306-us58wwmp 512 9 who who WP cord-015306-us58wwmp 512 10 completed complete VBD cord-015306-us58wwmp 512 11 the the DT cord-015306-us58wwmp 512 12 questionnaire questionnaire NN cord-015306-us58wwmp 512 13 , , , cord-015306-us58wwmp 512 14 183 183 CD cord-015306-us58wwmp 512 15 reported report VBD cord-015306-us58wwmp 512 16 nocturia nocturia NNS cord-015306-us58wwmp 512 17 ( ( -LRB- cord-015306-us58wwmp 512 18 36 36 CD cord-015306-us58wwmp 512 19 % % NN cord-015306-us58wwmp 512 20 ) ) -RRB- cord-015306-us58wwmp 512 21 , , , cord-015306-us58wwmp 512 22 with with IN cord-015306-us58wwmp 512 23 a a DT cord-015306-us58wwmp 512 24 sex sex NN cord-015306-us58wwmp 512 25 ratio ratio NN cord-015306-us58wwmp 512 26 ( ( -LRB- cord-015306-us58wwmp 512 27 M M NNP cord-015306-us58wwmp 512 28 / / SYM cord-015306-us58wwmp 512 29 F F NNP cord-015306-us58wwmp 512 30 ) ) -RRB- cord-015306-us58wwmp 512 31 of of IN cord-015306-us58wwmp 512 32 101/81 101/81 CD cord-015306-us58wwmp 512 33 in in IN cord-015306-us58wwmp 512 34 the the DT cord-015306-us58wwmp 512 35 nocturic nocturic NNP cord-015306-us58wwmp 512 36 group group NNP cord-015306-us58wwmp 512 37 versus versus IN cord-015306-us58wwmp 512 38 230/103 230/103 CD cord-015306-us58wwmp 512 39 in in IN cord-015306-us58wwmp 512 40 the the DT cord-015306-us58wwmp 512 41 non non JJ cord-015306-us58wwmp 512 42 - - JJ cord-015306-us58wwmp 512 43 nocturic nocturic JJ cord-015306-us58wwmp 512 44 group group NN cord-015306-us58wwmp 512 45 , , , cord-015306-us58wwmp 512 46 mean mean JJ cord-015306-us58wwmp 512 47 age age NN cord-015306-us58wwmp 512 48 is be VBZ cord-015306-us58wwmp 512 49 18 18 CD cord-015306-us58wwmp 512 50 versus versus IN cord-015306-us58wwmp 512 51 17 17 CD cord-015306-us58wwmp 512 52 years year NNS cord-015306-us58wwmp 512 53 old old JJ cord-015306-us58wwmp 512 54 , , , cord-015306-us58wwmp 512 55 respectively respectively RB cord-015306-us58wwmp 512 56 . . . cord-015306-us58wwmp 513 1 Comparing compare VBG cord-015306-us58wwmp 513 2 the the DT cord-015306-us58wwmp 513 3 nocturic nocturic NNP cord-015306-us58wwmp 513 4 and and CC cord-015306-us58wwmp 513 5 nonnocturic nonnocturic NNP cord-015306-us58wwmp 513 6 group group NNP cord-015306-us58wwmp 513 7 , , , cord-015306-us58wwmp 513 8 retrospective retrospective JJ cord-015306-us58wwmp 513 9 analysis analysis NN cord-015306-us58wwmp 513 10 of of IN cord-015306-us58wwmp 513 11 the the DT cord-015306-us58wwmp 513 12 history history NN cord-015306-us58wwmp 513 13 of of IN cord-015306-us58wwmp 513 14 enuresis enuresis NN cord-015306-us58wwmp 513 15 shows show VBZ cord-015306-us58wwmp 513 16 an an DT cord-015306-us58wwmp 513 17 older old JJR cord-015306-us58wwmp 513 18 age age NN cord-015306-us58wwmp 513 19 at at IN cord-015306-us58wwmp 513 20 which which WDT cord-015306-us58wwmp 513 21 the the DT cord-015306-us58wwmp 513 22 subjects subject NNS cord-015306-us58wwmp 513 23 were be VBD cord-015306-us58wwmp 513 24 cured cure VBN cord-015306-us58wwmp 513 25 ( ( -LRB- cord-015306-us58wwmp 513 26 10 10 CD cord-015306-us58wwmp 513 27 vs vs IN cord-015306-us58wwmp 513 28 9.5 9.5 CD cord-015306-us58wwmp 513 29 , , , cord-015306-us58wwmp 513 30 respectively respectively RB cord-015306-us58wwmp 513 31 ) ) -RRB- cord-015306-us58wwmp 513 32 and and CC cord-015306-us58wwmp 513 33 a a DT cord-015306-us58wwmp 513 34 higher high JJR cord-015306-us58wwmp 513 35 percentage percentage NN cord-015306-us58wwmp 513 36 of of IN cord-015306-us58wwmp 513 37 non non JJ cord-015306-us58wwmp 513 38 - - JJ cord-015306-us58wwmp 513 39 monosymptomatic monosymptomatic JJ cord-015306-us58wwmp 513 40 NE NE NNP cord-015306-us58wwmp 513 41 ( ( -LRB- cord-015306-us58wwmp 513 42 74 74 CD cord-015306-us58wwmp 513 43 % % NN cord-015306-us58wwmp 513 44 vs vs IN cord-015306-us58wwmp 513 45 63 63 CD cord-015306-us58wwmp 513 46 % % NN cord-015306-us58wwmp 513 47 , , , cord-015306-us58wwmp 513 48 respectively respectively RB cord-015306-us58wwmp 513 49 ) ) -RRB- cord-015306-us58wwmp 513 50 in in IN cord-015306-us58wwmp 513 51 the the DT cord-015306-us58wwmp 513 52 nocturic nocturic NNP cord-015306-us58wwmp 513 53 group group NNP cord-015306-us58wwmp 513 54 . . . cord-015306-us58wwmp 514 1 No no DT cord-015306-us58wwmp 514 2 differences difference NNS cord-015306-us58wwmp 514 3 in in IN cord-015306-us58wwmp 514 4 past past JJ cord-015306-us58wwmp 514 5 treatment treatment NN cord-015306-us58wwmp 514 6 for for IN cord-015306-us58wwmp 514 7 NE NE NNP cord-015306-us58wwmp 514 8 were be VBD cord-015306-us58wwmp 514 9 found find VBN cord-015306-us58wwmp 514 10 between between IN cord-015306-us58wwmp 514 11 both both DT cord-015306-us58wwmp 514 12 groups group NNS cord-015306-us58wwmp 514 13 . . . cord-015306-us58wwmp 515 1 Prospective prospective JJ cord-015306-us58wwmp 515 2 analysis analysis NN cord-015306-us58wwmp 515 3 shows show VBZ cord-015306-us58wwmp 515 4 a a DT cord-015306-us58wwmp 515 5 significantly significantly RB cord-015306-us58wwmp 515 6 higher high JJR cord-015306-us58wwmp 515 7 prevalence prevalence NN cord-015306-us58wwmp 515 8 ( ( -LRB- cord-015306-us58wwmp 515 9 p<0.001 p<0.001 JJ cord-015306-us58wwmp 515 10 ) ) -RRB- cord-015306-us58wwmp 515 11 of of IN cord-015306-us58wwmp 515 12 voiding void VBG cord-015306-us58wwmp 515 13 frequency frequency NN cord-015306-us58wwmp 515 14 during during IN cord-015306-us58wwmp 515 15 daytime daytime NN cord-015306-us58wwmp 515 16 , , , cord-015306-us58wwmp 515 17 urge urge VB cord-015306-us58wwmp 515 18 and and CC cord-015306-us58wwmp 515 19 urinary urinary JJ cord-015306-us58wwmp 515 20 incontinence incontinence NN cord-015306-us58wwmp 515 21 in in IN cord-015306-us58wwmp 515 22 nocturics nocturic NNS cord-015306-us58wwmp 515 23 compared compare VBN cord-015306-us58wwmp 515 24 to to IN cord-015306-us58wwmp 515 25 nonnocturics nonnocturic NNS cord-015306-us58wwmp 515 26 . . . cord-015306-us58wwmp 516 1 With with IN cord-015306-us58wwmp 516 2 an an DT cord-015306-us58wwmp 516 3 increase increase NN cord-015306-us58wwmp 516 4 in in IN cord-015306-us58wwmp 516 5 number number NN cord-015306-us58wwmp 516 6 of of IN cord-015306-us58wwmp 516 7 nocturic nocturic JJ cord-015306-us58wwmp 516 8 episodes episode NNS cord-015306-us58wwmp 516 9 per per IN cord-015306-us58wwmp 516 10 night night NN cord-015306-us58wwmp 516 11 , , , cord-015306-us58wwmp 516 12 the the DT cord-015306-us58wwmp 516 13 percentage percentage NN cord-015306-us58wwmp 516 14 of of IN cord-015306-us58wwmp 516 15 female female JJ cord-015306-us58wwmp 516 16 subjects subject NNS cord-015306-us58wwmp 516 17 increases increase VBZ cord-015306-us58wwmp 516 18 ( ( -LRB- cord-015306-us58wwmp 516 19 p<0.001 p<0.001 CD cord-015306-us58wwmp 516 20 ) ) -RRB- cord-015306-us58wwmp 516 21 and and CC cord-015306-us58wwmp 516 22 the the DT cord-015306-us58wwmp 516 23 percentage percentage NN cord-015306-us58wwmp 516 24 of of IN cord-015306-us58wwmp 516 25 subjects subject NNS cord-015306-us58wwmp 516 26 with with IN cord-015306-us58wwmp 516 27 non non JJ cord-015306-us58wwmp 516 28 - - JJ cord-015306-us58wwmp 516 29 monosymptomatic monosymptomatic JJ cord-015306-us58wwmp 516 30 NE NE NNP cord-015306-us58wwmp 516 31 increases increase VBZ cord-015306-us58wwmp 516 32 as as RB cord-015306-us58wwmp 516 33 well well RB cord-015306-us58wwmp 516 34 ( ( -LRB- cord-015306-us58wwmp 516 35 p<0.011 p<0.011 NNP cord-015306-us58wwmp 516 36 ) ) -RRB- cord-015306-us58wwmp 516 37 . . . cord-015306-us58wwmp 517 1 Conclusion conclusion NN cord-015306-us58wwmp 517 2 : : : cord-015306-us58wwmp 517 3 Over over IN cord-015306-us58wwmp 517 4 one one CD cord-015306-us58wwmp 517 5 out out IN cord-015306-us58wwmp 517 6 of of IN cord-015306-us58wwmp 517 7 3 3 CD cord-015306-us58wwmp 517 8 former former JJ cord-015306-us58wwmp 517 9 enuretic enuretic JJ cord-015306-us58wwmp 517 10 patients patient NNS cord-015306-us58wwmp 517 11 develops develop VBZ cord-015306-us58wwmp 517 12 nocturia nocturia NNS cord-015306-us58wwmp 517 13 , , , cord-015306-us58wwmp 517 14 often often RB cord-015306-us58wwmp 517 15 accompanied accompany VBN cord-015306-us58wwmp 517 16 by by IN cord-015306-us58wwmp 517 17 other other JJ cord-015306-us58wwmp 517 18 urinary urinary JJ cord-015306-us58wwmp 517 19 symptoms symptom NNS cord-015306-us58wwmp 517 20 and and CC cord-015306-us58wwmp 517 21 with with IN cord-015306-us58wwmp 517 22 significant significant JJ cord-015306-us58wwmp 517 23 bother bother NN cord-015306-us58wwmp 517 24 . . . cord-015306-us58wwmp 518 1 Cure cure NN cord-015306-us58wwmp 518 2 of of IN cord-015306-us58wwmp 518 3 nocturnal nocturnal JJ cord-015306-us58wwmp 518 4 enuresis enuresis NN cord-015306-us58wwmp 518 5 does do VBZ cord-015306-us58wwmp 518 6 not not RB cord-015306-us58wwmp 518 7 necessarily necessarily RB cord-015306-us58wwmp 518 8 equals equal VBZ cord-015306-us58wwmp 518 9 cure cure NN cord-015306-us58wwmp 518 10 of of IN cord-015306-us58wwmp 518 11 the the DT cord-015306-us58wwmp 518 12 urological urological JJ cord-015306-us58wwmp 518 13 pathology pathology NN cord-015306-us58wwmp 518 14 and and CC cord-015306-us58wwmp 518 15 some some DT cord-015306-us58wwmp 518 16 of of IN cord-015306-us58wwmp 518 17 the the DT cord-015306-us58wwmp 518 18 nocturic nocturic JJ cord-015306-us58wwmp 518 19 patients patient NNS cord-015306-us58wwmp 518 20 , , , cord-015306-us58wwmp 518 21 who who WP cord-015306-us58wwmp 518 22 remain remain VBP cord-015306-us58wwmp 518 23 to to TO cord-015306-us58wwmp 518 24 suffer suffer VB cord-015306-us58wwmp 518 25 from from IN cord-015306-us58wwmp 518 26 bothersome bothersome JJ cord-015306-us58wwmp 518 27 symptoms symptom NNS cord-015306-us58wwmp 518 28 , , , cord-015306-us58wwmp 518 29 might may MD cord-015306-us58wwmp 518 30 benefit benefit VB cord-015306-us58wwmp 518 31 from from IN cord-015306-us58wwmp 518 32 continuous continuous JJ cord-015306-us58wwmp 518 33 treatment treatment NN cord-015306-us58wwmp 518 34 for for IN cord-015306-us58wwmp 518 35 the the DT cord-015306-us58wwmp 518 36 underlying underlie VBG cord-015306-us58wwmp 518 37 urological urological JJ cord-015306-us58wwmp 518 38 condition condition NN cord-015306-us58wwmp 518 39 , , , cord-015306-us58wwmp 518 40 such such JJ cord-015306-us58wwmp 518 41 as as IN cord-015306-us58wwmp 518 42 overactive overactive JJ cord-015306-us58wwmp 518 43 bladder bladder NN cord-015306-us58wwmp 518 44 syndrome syndrome NN cord-015306-us58wwmp 518 45 or or CC cord-015306-us58wwmp 518 46 nocturnal nocturnal JJ cord-015306-us58wwmp 518 47 polyuria polyuria NN cord-015306-us58wwmp 518 48 . . . cord-015306-us58wwmp 519 1 Objectives objective NNS cord-015306-us58wwmp 519 2 , , , cord-015306-us58wwmp 519 3 Methods Methods NNPS cord-015306-us58wwmp 519 4 and and CC cord-015306-us58wwmp 519 5 Results result NNS cord-015306-us58wwmp 519 6 : : : cord-015306-us58wwmp 519 7 A a DT cord-015306-us58wwmp 519 8 3 3 CD cord-015306-us58wwmp 519 9 year year NN cord-015306-us58wwmp 519 10 old old JJ cord-015306-us58wwmp 519 11 girl girl NN cord-015306-us58wwmp 519 12 was be VBD cord-015306-us58wwmp 519 13 admitted admit VBN cord-015306-us58wwmp 519 14 to to IN cord-015306-us58wwmp 519 15 our -PRON- PRP$ cord-015306-us58wwmp 519 16 hospital hospital NN cord-015306-us58wwmp 519 17 due due IN cord-015306-us58wwmp 519 18 to to IN cord-015306-us58wwmp 519 19 unusual unusual JJ cord-015306-us58wwmp 519 20 pattern pattern NN cord-015306-us58wwmp 519 21 of of IN cord-015306-us58wwmp 519 22 voiding voiding NN cord-015306-us58wwmp 519 23 . . . cord-015306-us58wwmp 520 1 When when WRB cord-015306-us58wwmp 520 2 she -PRON- PRP cord-015306-us58wwmp 520 3 wanted want VBD cord-015306-us58wwmp 520 4 to to TO cord-015306-us58wwmp 520 5 urinate urinate VB cord-015306-us58wwmp 520 6 , , , cord-015306-us58wwmp 520 7 she -PRON- PRP cord-015306-us58wwmp 520 8 was be VBD cord-015306-us58wwmp 520 9 writhing writhe VBG cord-015306-us58wwmp 520 10 in in IN cord-015306-us58wwmp 520 11 pain pain NN cord-015306-us58wwmp 520 12 ; ; : cord-015306-us58wwmp 520 13 she -PRON- PRP cord-015306-us58wwmp 520 14 cried cry VBD cord-015306-us58wwmp 520 15 , , , cord-015306-us58wwmp 520 16 became become VBD cord-015306-us58wwmp 520 17 pale pale JJ cord-015306-us58wwmp 520 18 and and CC cord-015306-us58wwmp 520 19 sweated sweat VBD cord-015306-us58wwmp 520 20 . . . cord-015306-us58wwmp 521 1 Since since IN cord-015306-us58wwmp 521 2 the the DT cord-015306-us58wwmp 521 3 newborn newborn JJ cord-015306-us58wwmp 521 4 period period NN cord-015306-us58wwmp 521 5 parents parent NNS cord-015306-us58wwmp 521 6 have have VBP cord-015306-us58wwmp 521 7 observed observe VBN cord-015306-us58wwmp 521 8 sudden sudden JJ cord-015306-us58wwmp 521 9 episodes episode NNS cord-015306-us58wwmp 521 10 when when WRB cord-015306-us58wwmp 521 11 the the DT cord-015306-us58wwmp 521 12 girl girl NN cord-015306-us58wwmp 521 13 started start VBD cord-015306-us58wwmp 521 14 to to TO cord-015306-us58wwmp 521 15 cry cry VB cord-015306-us58wwmp 521 16 and and CC cord-015306-us58wwmp 521 17 curled curl VBD cord-015306-us58wwmp 521 18 up up RP cord-015306-us58wwmp 521 19 her -PRON- PRP$ cord-015306-us58wwmp 521 20 legs leg NNS cord-015306-us58wwmp 521 21 . . . cord-015306-us58wwmp 522 1 She -PRON- PRP cord-015306-us58wwmp 522 2 stopped stop VBD cord-015306-us58wwmp 522 3 when when WRB cord-015306-us58wwmp 522 4 she -PRON- PRP cord-015306-us58wwmp 522 5 began begin VBD cord-015306-us58wwmp 522 6 to to TO cord-015306-us58wwmp 522 7 urinate urinate VB cord-015306-us58wwmp 522 8 . . . cord-015306-us58wwmp 523 1 The the DT cord-015306-us58wwmp 523 2 girl girl NN cord-015306-us58wwmp 523 3 's 's POS cord-015306-us58wwmp 523 4 father father NN cord-015306-us58wwmp 523 5 occasionally occasionally RB cord-015306-us58wwmp 523 6 had have VBD cord-015306-us58wwmp 523 7 pains pain NNS cord-015306-us58wwmp 523 8 in in IN cord-015306-us58wwmp 523 9 the the DT cord-015306-us58wwmp 523 10 jaw jaw NN cord-015306-us58wwmp 523 11 between between IN cord-015306-us58wwmp 523 12 yawning yawning NN cord-015306-us58wwmp 523 13 . . . cord-015306-us58wwmp 524 1 The the DT cord-015306-us58wwmp 524 2 girl girl NN cord-015306-us58wwmp 524 3 's 's POS cord-015306-us58wwmp 524 4 voiding voiding NN cord-015306-us58wwmp 524 5 was be VBD cord-015306-us58wwmp 524 6 like like IN cord-015306-us58wwmp 524 7 parents parent NNS cord-015306-us58wwmp 524 8 described describe VBN cord-015306-us58wwmp 524 9 : : : cord-015306-us58wwmp 524 10 when when WRB cord-015306-us58wwmp 524 11 she -PRON- PRP cord-015306-us58wwmp 524 12 was be VBD cord-015306-us58wwmp 524 13 trying try VBG cord-015306-us58wwmp 524 14 to to TO cord-015306-us58wwmp 524 15 begin begin VB cord-015306-us58wwmp 524 16 urinating urinate VBG cord-015306-us58wwmp 524 17 , , , cord-015306-us58wwmp 524 18 she -PRON- PRP cord-015306-us58wwmp 524 19 was be VBD cord-015306-us58wwmp 524 20 squatting squat VBG cord-015306-us58wwmp 524 21 on on IN cord-015306-us58wwmp 524 22 the the DT cord-015306-us58wwmp 524 23 toilet toilet NN cord-015306-us58wwmp 524 24 seat seat NN cord-015306-us58wwmp 524 25 , , , cord-015306-us58wwmp 524 26 crying cry VBG cord-015306-us58wwmp 524 27 and and CC cord-015306-us58wwmp 524 28 became become VBD cord-015306-us58wwmp 524 29 pale pale JJ cord-015306-us58wwmp 524 30 and and CC cord-015306-us58wwmp 524 31 sweated sweat VBD cord-015306-us58wwmp 524 32 . . . cord-015306-us58wwmp 525 1 When when WRB cord-015306-us58wwmp 525 2 voiding void VBG cord-015306-us58wwmp 525 3 occurred occur VBD cord-015306-us58wwmp 525 4 the the DT cord-015306-us58wwmp 525 5 girl girl NN cord-015306-us58wwmp 525 6 seemed seem VBD cord-015306-us58wwmp 525 7 to to TO cord-015306-us58wwmp 525 8 relax relax VB cord-015306-us58wwmp 525 9 . . . cord-015306-us58wwmp 526 1 The the DT cord-015306-us58wwmp 526 2 voiding voiding NN cord-015306-us58wwmp 526 3 volume volume NN cord-015306-us58wwmp 526 4 was be VBD cord-015306-us58wwmp 526 5 small small JJ cord-015306-us58wwmp 526 6 and and CC cord-015306-us58wwmp 526 7 the the DT cord-015306-us58wwmp 526 8 urinary urinary JJ cord-015306-us58wwmp 526 9 stream stream NN cord-015306-us58wwmp 526 10 was be VBD cord-015306-us58wwmp 526 11 weak weak JJ cord-015306-us58wwmp 526 12 . . . cord-015306-us58wwmp 527 1 All all DT cord-015306-us58wwmp 527 2 investigations investigation NNS cord-015306-us58wwmp 527 3 results result NNS cord-015306-us58wwmp 527 4 were be VBD cord-015306-us58wwmp 527 5 normal normal JJ cord-015306-us58wwmp 527 6 . . . cord-015306-us58wwmp 528 1 According accord VBG cord-015306-us58wwmp 528 2 to to IN cord-015306-us58wwmp 528 3 the the DT cord-015306-us58wwmp 528 4 clinical clinical JJ cord-015306-us58wwmp 528 5 course course NN cord-015306-us58wwmp 528 6 we -PRON- PRP cord-015306-us58wwmp 528 7 assumed assume VBD cord-015306-us58wwmp 528 8 that that IN cord-015306-us58wwmp 528 9 the the DT cord-015306-us58wwmp 528 10 girl girl NN cord-015306-us58wwmp 528 11 had have VBD cord-015306-us58wwmp 528 12 an an DT cord-015306-us58wwmp 528 13 unusual unusual JJ cord-015306-us58wwmp 528 14 expression expression NN cord-015306-us58wwmp 528 15 of of IN cord-015306-us58wwmp 528 16 Paroxysmal Paroxysmal NNP cord-015306-us58wwmp 528 17 extreme extreme JJ cord-015306-us58wwmp 528 18 pain pain NN cord-015306-us58wwmp 528 19 disorder disorder NN cord-015306-us58wwmp 528 20 ( ( -LRB- cord-015306-us58wwmp 528 21 PEPD PEPD NNP cord-015306-us58wwmp 528 22 ) ) -RRB- cord-015306-us58wwmp 528 23 . . . cord-015306-us58wwmp 529 1 The the DT cord-015306-us58wwmp 529 2 diagnosis diagnosis NN cord-015306-us58wwmp 529 3 was be VBD cord-015306-us58wwmp 529 4 confirmed confirm VBN cord-015306-us58wwmp 529 5 by by IN cord-015306-us58wwmp 529 6 the the DT cord-015306-us58wwmp 529 7 detection detection NN cord-015306-us58wwmp 529 8 of of IN cord-015306-us58wwmp 529 9 the the DT cord-015306-us58wwmp 529 10 heterozygous heterozygous JJ cord-015306-us58wwmp 529 11 pathogenic pathogenic JJ cord-015306-us58wwmp 529 12 mutation mutation NN cord-015306-us58wwmp 529 13 in in IN cord-015306-us58wwmp 529 14 the the DT cord-015306-us58wwmp 529 15 SCN9A SCN9A NNS cord-015306-us58wwmp 529 16 gene gene NN cord-015306-us58wwmp 529 17 , , , cord-015306-us58wwmp 529 18 a a DT cord-015306-us58wwmp 529 19 missense missense JJ cord-015306-us58wwmp 529 20 mutation mutation NN cord-015306-us58wwmp 529 21 in in IN cord-015306-us58wwmp 529 22 exon exon NN cord-015306-us58wwmp 529 23 5 5 CD cord-015306-us58wwmp 529 24 . . . cord-015306-us58wwmp 530 1 The the DT cord-015306-us58wwmp 530 2 same same JJ cord-015306-us58wwmp 530 3 mutation mutation NN cord-015306-us58wwmp 530 4 was be VBD cord-015306-us58wwmp 530 5 also also RB cord-015306-us58wwmp 530 6 confirmed confirm VBN cord-015306-us58wwmp 530 7 in in IN cord-015306-us58wwmp 530 8 her -PRON- PRP$ cord-015306-us58wwmp 530 9 father father NN cord-015306-us58wwmp 530 10 . . . cord-015306-us58wwmp 531 1 The the DT cord-015306-us58wwmp 531 2 girl girl NN cord-015306-us58wwmp 531 3 was be VBD cord-015306-us58wwmp 531 4 started start VBN cord-015306-us58wwmp 531 5 on on IN cord-015306-us58wwmp 531 6 carbamazepine carbamazepine NN cord-015306-us58wwmp 531 7 and and CC cord-015306-us58wwmp 531 8 the the DT cord-015306-us58wwmp 531 9 pain pain NN cord-015306-us58wwmp 531 10 attacks attack NNS cord-015306-us58wwmp 531 11 almost almost RB cord-015306-us58wwmp 531 12 disappeared disappear VBD cord-015306-us58wwmp 531 13 . . . cord-015306-us58wwmp 532 1 PEPD PEPD NNP cord-015306-us58wwmp 532 2 is be VBZ cord-015306-us58wwmp 532 3 a a DT cord-015306-us58wwmp 532 4 rare rare JJ cord-015306-us58wwmp 532 5 autosomal autosomal JJ cord-015306-us58wwmp 532 6 dominant dominant JJ cord-015306-us58wwmp 532 7 neuropathy neuropathy NN cord-015306-us58wwmp 532 8 linked link VBN cord-015306-us58wwmp 532 9 to to IN cord-015306-us58wwmp 532 10 mutation mutation NN cord-015306-us58wwmp 532 11 in in IN cord-015306-us58wwmp 532 12 the the DT cord-015306-us58wwmp 532 13 SCN9A SCN9A NNS cord-015306-us58wwmp 532 14 gene gene NN cord-015306-us58wwmp 532 15 which which WDT cord-015306-us58wwmp 532 16 encodes encode VBZ cord-015306-us58wwmp 532 17 voltage voltage NN cord-015306-us58wwmp 532 18 - - HYPH cord-015306-us58wwmp 532 19 gated gate VBN cord-015306-us58wwmp 532 20 sodium sodium NN cord-015306-us58wwmp 532 21 channels channel NNS cord-015306-us58wwmp 532 22 . . . cord-015306-us58wwmp 533 1 Abnormal abnormal JJ cord-015306-us58wwmp 533 2 pain pain NN cord-015306-us58wwmp 533 3 sensitivity sensitivity NN cord-015306-us58wwmp 533 4 occurs occur VBZ cord-015306-us58wwmp 533 5 due due IN cord-015306-us58wwmp 533 6 to to IN cord-015306-us58wwmp 533 7 changes change NNS cord-015306-us58wwmp 533 8 in in IN cord-015306-us58wwmp 533 9 the the DT cord-015306-us58wwmp 533 10 properties property NNS cord-015306-us58wwmp 533 11 of of IN cord-015306-us58wwmp 533 12 the the DT cord-015306-us58wwmp 533 13 channels channel NNS cord-015306-us58wwmp 533 14 . . . cord-015306-us58wwmp 534 1 PEPD PEPD NNP cord-015306-us58wwmp 534 2 's 's POS cord-015306-us58wwmp 534 3 onset onset NN cord-015306-us58wwmp 534 4 is be VBZ cord-015306-us58wwmp 534 5 in in IN cord-015306-us58wwmp 534 6 the the DT cord-015306-us58wwmp 534 7 neonatal neonatal JJ cord-015306-us58wwmp 534 8 period period NN cord-015306-us58wwmp 534 9 with with IN cord-015306-us58wwmp 534 10 the the DT cord-015306-us58wwmp 534 11 most most RBS cord-015306-us58wwmp 534 12 characteristic characteristic JJ cord-015306-us58wwmp 534 13 clinical clinical JJ cord-015306-us58wwmp 534 14 features feature NNS cord-015306-us58wwmp 534 15 being be VBG cord-015306-us58wwmp 534 16 attacks attack NNS cord-015306-us58wwmp 534 17 of of IN cord-015306-us58wwmp 534 18 excruciating excruciating JJ cord-015306-us58wwmp 534 19 pain pain NN cord-015306-us58wwmp 534 20 in in IN cord-015306-us58wwmp 534 21 the the DT cord-015306-us58wwmp 534 22 rectum rectum NN cord-015306-us58wwmp 534 23 , , , cord-015306-us58wwmp 534 24 genitalia genitalia NNS cord-015306-us58wwmp 534 25 , , , cord-015306-us58wwmp 534 26 face face NN cord-015306-us58wwmp 534 27 and and CC cord-015306-us58wwmp 534 28 limbs limb NNS cord-015306-us58wwmp 534 29 . . . cord-015306-us58wwmp 535 1 In in IN cord-015306-us58wwmp 535 2 literature literature NN cord-015306-us58wwmp 535 3 we -PRON- PRP cord-015306-us58wwmp 535 4 did do VBD cord-015306-us58wwmp 535 5 not not RB cord-015306-us58wwmp 535 6 find find VB cord-015306-us58wwmp 535 7 any any DT cord-015306-us58wwmp 535 8 citation citation NN cord-015306-us58wwmp 535 9 of of IN cord-015306-us58wwmp 535 10 patients patient NNS cord-015306-us58wwmp 535 11 with with IN cord-015306-us58wwmp 535 12 attacks attack NNS cord-015306-us58wwmp 535 13 triggered trigger VBN cord-015306-us58wwmp 535 14 by by IN cord-015306-us58wwmp 535 15 the the DT cord-015306-us58wwmp 535 16 voiding void VBG cord-015306-us58wwmp 535 17 stimulus stimulus NN cord-015306-us58wwmp 535 18 . . . cord-015306-us58wwmp 536 1 Carbamazepine carbamazepine NN cord-015306-us58wwmp 536 2 has have VBZ cord-015306-us58wwmp 536 3 been be VBN cord-015306-us58wwmp 536 4 effective effective JJ cord-015306-us58wwmp 536 5 in in IN cord-015306-us58wwmp 536 6 relieving relieve VBG cord-015306-us58wwmp 536 7 symptoms symptom NNS cord-015306-us58wwmp 536 8 but but CC cord-015306-us58wwmp 536 9 the the DT cord-015306-us58wwmp 536 10 response response NN cord-015306-us58wwmp 536 11 is be VBZ cord-015306-us58wwmp 536 12 often often RB cord-015306-us58wwmp 536 13 incomplete incomplete JJ cord-015306-us58wwmp 536 14 ( ( -LRB- cord-015306-us58wwmp 536 15 1 1 CD cord-015306-us58wwmp 536 16 ) ) -RRB- cord-015306-us58wwmp 537 1 ( ( -LRB- cord-015306-us58wwmp 537 2 2 2 LS cord-015306-us58wwmp 537 3 ) ) -RRB- cord-015306-us58wwmp 537 4 ( ( -LRB- cord-015306-us58wwmp 537 5 3 3 LS cord-015306-us58wwmp 537 6 ) ) -RRB- cord-015306-us58wwmp 537 7 , , , cord-015306-us58wwmp 537 8 as as IN cord-015306-us58wwmp 537 9 in in IN cord-015306-us58wwmp 537 10 our -PRON- PRP$ cord-015306-us58wwmp 537 11 patient patient NN cord-015306-us58wwmp 537 12 . . . cord-015306-us58wwmp 538 1 Conclusion conclusion NN cord-015306-us58wwmp 538 2 : : : cord-015306-us58wwmp 539 1 The the DT cord-015306-us58wwmp 539 2 case case NN cord-015306-us58wwmp 539 3 described describe VBN cord-015306-us58wwmp 539 4 is be VBZ cord-015306-us58wwmp 539 5 interesting interesting JJ cord-015306-us58wwmp 539 6 because because IN cord-015306-us58wwmp 539 7 of of IN cord-015306-us58wwmp 539 8 the the DT cord-015306-us58wwmp 539 9 rare rare JJ cord-015306-us58wwmp 539 10 clinical clinical JJ cord-015306-us58wwmp 539 11 expression expression NN cord-015306-us58wwmp 539 12 of of IN cord-015306-us58wwmp 539 13 PEPD PEPD NNP cord-015306-us58wwmp 539 14 with with IN cord-015306-us58wwmp 539 15 pain pain NN cord-015306-us58wwmp 539 16 triggered trigger VBN cord-015306-us58wwmp 539 17 by by IN cord-015306-us58wwmp 539 18 voiding void VBG cord-015306-us58wwmp 539 19 . . . cord-015306-us58wwmp 540 1 The the DT cord-015306-us58wwmp 540 2 same same JJ cord-015306-us58wwmp 540 3 mutation mutation NN cord-015306-us58wwmp 540 4 was be VBD cord-015306-us58wwmp 540 5 recently recently RB cord-015306-us58wwmp 540 6 found find VBN cord-015306-us58wwmp 540 7 in in IN cord-015306-us58wwmp 540 8 patients patient NNS cord-015306-us58wwmp 540 9 with with IN cord-015306-us58wwmp 540 10 SFN SFN NNP cord-015306-us58wwmp 540 11 ( ( -LRB- cord-015306-us58wwmp 540 12 4 4 CD cord-015306-us58wwmp 540 13 ) ) -RRB- cord-015306-us58wwmp 540 14 . . . cord-015306-us58wwmp 541 1 The the DT cord-015306-us58wwmp 541 2 study study NN cord-015306-us58wwmp 541 3 of of IN cord-015306-us58wwmp 541 4 functional functional JJ cord-015306-us58wwmp 541 5 importance importance NN cord-015306-us58wwmp 541 6 of of IN cord-015306-us58wwmp 541 7 this this DT cord-015306-us58wwmp 541 8 mutation mutation NN cord-015306-us58wwmp 541 9 showed show VBD cord-015306-us58wwmp 541 10 that that IN cord-015306-us58wwmp 541 11 the the DT cord-015306-us58wwmp 541 12 result result NN cord-015306-us58wwmp 541 13 of of IN cord-015306-us58wwmp 541 14 the the DT cord-015306-us58wwmp 541 15 mutation mutation NN cord-015306-us58wwmp 541 16 is be VBZ cord-015306-us58wwmp 541 17 increased increase VBN cord-015306-us58wwmp 541 18 frequency frequency NN cord-015306-us58wwmp 541 19 of of IN cord-015306-us58wwmp 541 20 firing fire VBG cord-015306-us58wwmp 541 21 pain pain NN cord-015306-us58wwmp 541 22 - - HYPH cord-015306-us58wwmp 541 23 signaling signal VBG cord-015306-us58wwmp 541 24 neurons neuron NNS cord-015306-us58wwmp 541 25 ( ( -LRB- cord-015306-us58wwmp 541 26 5 5 CD cord-015306-us58wwmp 541 27 ) ) -RRB- cord-015306-us58wwmp 541 28 . . . cord-015306-us58wwmp 542 1 Rita Rita NNP cord-015306-us58wwmp 542 2 Pavione Pavione NNP cord-015306-us58wwmp 542 3 Rodrigues Rodrigues NNP cord-015306-us58wwmp 542 4 Pereira Pereira NNP cord-015306-us58wwmp 542 5 1 1 CD cord-015306-us58wwmp 542 6 , , , cord-015306-us58wwmp 542 7 Vera Vera NNP cord-015306-us58wwmp 542 8 HerminaKalika HerminaKalika NNP cord-015306-us58wwmp 542 9 Koch Koch NNP cord-015306-us58wwmp 542 10 2 2 CD cord-015306-us58wwmp 542 11 , , , cord-015306-us58wwmp 542 12 Simone Simone NNP cord-015306-us58wwmp 542 13 Nascimento Nascimento NNP cord-015306-us58wwmp 542 14 Fagundes Fagundes NNP cord-015306-us58wwmp 542 15 2 2 CD cord-015306-us58wwmp 542 16 , , , cord-015306-us58wwmp 542 17 Aline Aline NNP cord-015306-us58wwmp 542 18 Rossi Rossi NNP cord-015306-us58wwmp 542 19 1 1 CD cord-015306-us58wwmp 542 20 , , , cord-015306-us58wwmp 542 21 Juliane Juliane NNP cord-015306-us58wwmp 542 22 de de NNP cord-015306-us58wwmp 542 23 Oliveira Oliveira NNP cord-015306-us58wwmp 542 24 Marques Marques NNP cord-015306-us58wwmp 542 25 Vieira Vieira NNP cord-015306-us58wwmp 542 26 1 1 CD cord-015306-us58wwmp 542 27 , , , cord-015306-us58wwmp 542 28 Clarice Clarice NNP cord-015306-us58wwmp 542 29 Tanaka Tanaka NNP cord-015306-us58wwmp 542 30 1 1 CD cord-015306-us58wwmp 542 31 1 1 CD cord-015306-us58wwmp 542 32 Physical Physical NNP cord-015306-us58wwmp 542 33 Therapy Therapy NNP cord-015306-us58wwmp 542 34 , , , cord-015306-us58wwmp 542 35 University University NNP cord-015306-us58wwmp 542 36 of of IN cord-015306-us58wwmp 542 37 São São NNP cord-015306-us58wwmp 542 38 Paulo Paulo NNP cord-015306-us58wwmp 542 39 , , , cord-015306-us58wwmp 542 40 São São NNP cord-015306-us58wwmp 542 41 Paulo Paulo NNP cord-015306-us58wwmp 542 42 , , , cord-015306-us58wwmp 542 43 Brazil Brazil NNP cord-015306-us58wwmp 542 44 2 2 CD cord-015306-us58wwmp 542 45 Communication Communication NNP cord-015306-us58wwmp 542 46 Disorders Disorders NNPS cord-015306-us58wwmp 542 47 and and CC cord-015306-us58wwmp 542 48 Occupational Occupational NNP cord-015306-us58wwmp 542 49 Therapy Therapy NNP cord-015306-us58wwmp 542 50 , , , cord-015306-us58wwmp 542 51 University University NNP cord-015306-us58wwmp 542 52 of of IN cord-015306-us58wwmp 542 53 São São NNP cord-015306-us58wwmp 542 54 Paulo Paulo NNP cord-015306-us58wwmp 542 55 , , , cord-015306-us58wwmp 542 56 São São NNP cord-015306-us58wwmp 542 57 Paulo Paulo NNP cord-015306-us58wwmp 543 1 , , , cord-015306-us58wwmp 543 2 Brazil Brazil NNP cord-015306-us58wwmp 543 3 Objective Objective NNP cord-015306-us58wwmp 543 4 : : : cord-015306-us58wwmp 544 1 To to TO cord-015306-us58wwmp 544 2 assess assess VB cord-015306-us58wwmp 544 3 the the DT cord-015306-us58wwmp 544 4 postural postural JJ cord-015306-us58wwmp 544 5 control control NN cord-015306-us58wwmp 544 6 in in IN cord-015306-us58wwmp 544 7 children child NNS cord-015306-us58wwmp 544 8 and and CC cord-015306-us58wwmp 544 9 teenagers teenager NNS cord-015306-us58wwmp 544 10 with with IN cord-015306-us58wwmp 544 11 enuresis enuresis NN cord-015306-us58wwmp 544 12 compared compare VBN cord-015306-us58wwmp 544 13 to to IN cord-015306-us58wwmp 544 14 a a DT cord-015306-us58wwmp 544 15 control control NN cord-015306-us58wwmp 544 16 group group NN cord-015306-us58wwmp 544 17 Methods method NNS cord-015306-us58wwmp 544 18 : : : cord-015306-us58wwmp 544 19 22 22 CD cord-015306-us58wwmp 544 20 enuretic enuretic NN cord-015306-us58wwmp 544 21 ( ( -LRB- cord-015306-us58wwmp 544 22 EG EG NNP cord-015306-us58wwmp 544 23 ) ) -RRB- cord-015306-us58wwmp 544 24 patients patient NNS cord-015306-us58wwmp 544 25 ( ( -LRB- cord-015306-us58wwmp 544 26 11 11 CD cord-015306-us58wwmp 544 27 boys boy NNS cord-015306-us58wwmp 544 28 and and CC cord-015306-us58wwmp 544 29 11 11 CD cord-015306-us58wwmp 544 30 girls girl NNS cord-015306-us58wwmp 544 31 ) ) -RRB- cord-015306-us58wwmp 544 32 with with IN cord-015306-us58wwmp 544 33 mean± mean± NNP cord-015306-us58wwmp 544 34 SD SD NNP cord-015306-us58wwmp 544 35 of of IN cord-015306-us58wwmp 544 36 10.52±2.77 10.52±2.77 CD cord-015306-us58wwmp 544 37 years year NNS cord-015306-us58wwmp 544 38 , , , cord-015306-us58wwmp 544 39 ranging range VBG cord-015306-us58wwmp 544 40 from from IN cord-015306-us58wwmp 544 41 7 7 CD cord-015306-us58wwmp 544 42 to to TO cord-015306-us58wwmp 544 43 16 16 CD cord-015306-us58wwmp 544 44 years year NNS cord-015306-us58wwmp 544 45 old old JJ cord-015306-us58wwmp 544 46 , , , cord-015306-us58wwmp 544 47 and and CC cord-015306-us58wwmp 544 48 19.39±3.50 19.39±3.50 CD cord-015306-us58wwmp 544 49 of of IN cord-015306-us58wwmp 544 50 BMI BMI NNP cord-015306-us58wwmp 544 51 were be VBD cord-015306-us58wwmp 544 52 paired pair VBN cord-015306-us58wwmp 544 53 with with IN cord-015306-us58wwmp 544 54 assyntomatic assyntomatic JJ cord-015306-us58wwmp 544 55 kids kid NNS cord-015306-us58wwmp 544 56 ( ( -LRB- cord-015306-us58wwmp 544 57 CG CG NNP cord-015306-us58wwmp 544 58 ) ) -RRB- cord-015306-us58wwmp 544 59 of of IN cord-015306-us58wwmp 544 60 equal equal JJ cord-015306-us58wwmp 544 61 age age NN cord-015306-us58wwmp 544 62 , , , cord-015306-us58wwmp 544 63 gender gender NN cord-015306-us58wwmp 544 64 and and CC cord-015306-us58wwmp 544 65 BMI bmi NN cord-015306-us58wwmp 544 66 . . . cord-015306-us58wwmp 545 1 Three three CD cord-015306-us58wwmp 545 2 trials trial NNS cord-015306-us58wwmp 545 3 of of IN cord-015306-us58wwmp 545 4 20 20 CD cord-015306-us58wwmp 545 5 seconds second NNS cord-015306-us58wwmp 545 6 were be VBD cord-015306-us58wwmp 545 7 collected collect VBN cord-015306-us58wwmp 545 8 while while IN cord-015306-us58wwmp 545 9 standing stand VBG cord-015306-us58wwmp 545 10 on on IN cord-015306-us58wwmp 545 11 a a DT cord-015306-us58wwmp 545 12 forceplate forceplate NN cord-015306-us58wwmp 545 13 at at IN cord-015306-us58wwmp 545 14 60 60 CD cord-015306-us58wwmp 545 15 Hz Hz NNS cord-015306-us58wwmp 545 16 of of IN cord-015306-us58wwmp 545 17 frequency frequency NN cord-015306-us58wwmp 545 18 with with IN cord-015306-us58wwmp 545 19 standard standard JJ cord-015306-us58wwmp 545 20 position position NN cord-015306-us58wwmp 545 21 of of IN cord-015306-us58wwmp 545 22 feet foot NNS cord-015306-us58wwmp 545 23 in in IN cord-015306-us58wwmp 545 24 four four CD cord-015306-us58wwmp 545 25 different different JJ cord-015306-us58wwmp 545 26 sensorial sensorial JJ cord-015306-us58wwmp 545 27 conditions condition NNS cord-015306-us58wwmp 545 28 : : : cord-015306-us58wwmp 545 29 ( ( -LRB- cord-015306-us58wwmp 545 30 1 1 LS cord-015306-us58wwmp 545 31 ) ) -RRB- cord-015306-us58wwmp 545 32 open open JJ cord-015306-us58wwmp 545 33 eyes eye NNS cord-015306-us58wwmp 545 34 and and CC cord-015306-us58wwmp 545 35 stable stable JJ cord-015306-us58wwmp 545 36 surface surface NN cord-015306-us58wwmp 545 37 ; ; : cord-015306-us58wwmp 545 38 ( ( -LRB- cord-015306-us58wwmp 545 39 2 2 LS cord-015306-us58wwmp 545 40 ) ) -RRB- cord-015306-us58wwmp 545 41 closed close VBN cord-015306-us58wwmp 545 42 eyes eye NNS cord-015306-us58wwmp 545 43 and and CC cord-015306-us58wwmp 545 44 stable stable JJ cord-015306-us58wwmp 545 45 surface surface NN cord-015306-us58wwmp 545 46 ; ; : cord-015306-us58wwmp 546 1 ( ( -LRB- cord-015306-us58wwmp 546 2 3 3 LS cord-015306-us58wwmp 546 3 ) ) -RRB- cord-015306-us58wwmp 546 4 open open JJ cord-015306-us58wwmp 546 5 eyes eye NNS cord-015306-us58wwmp 546 6 and and CC cord-015306-us58wwmp 546 7 unstable unstable JJ cord-015306-us58wwmp 546 8 surface surface NN cord-015306-us58wwmp 546 9 , , , cord-015306-us58wwmp 546 10 and and CC cord-015306-us58wwmp 546 11 ; ; , cord-015306-us58wwmp 546 12 ( ( -LRB- cord-015306-us58wwmp 546 13 4 4 LS cord-015306-us58wwmp 546 14 ) ) -RRB- cord-015306-us58wwmp 546 15 closed close VBN cord-015306-us58wwmp 546 16 eyes eye NNS cord-015306-us58wwmp 546 17 and and CC cord-015306-us58wwmp 546 18 unstable unstable JJ cord-015306-us58wwmp 546 19 surface surface NN cord-015306-us58wwmp 546 20 . . . cord-015306-us58wwmp 547 1 The the DT cord-015306-us58wwmp 547 2 analized analize VBN cord-015306-us58wwmp 547 3 variables variable NNS cord-015306-us58wwmp 547 4 were be VBD cord-015306-us58wwmp 547 5 area area NN cord-015306-us58wwmp 547 6 ( ( -LRB- cord-015306-us58wwmp 547 7 A a NN cord-015306-us58wwmp 547 8 ) ) -RRB- cord-015306-us58wwmp 547 9 and and CC cord-015306-us58wwmp 547 10 velocity velocity NN cord-015306-us58wwmp 547 11 ( ( -LRB- cord-015306-us58wwmp 547 12 Vm Vm NNP cord-015306-us58wwmp 547 13 ) ) -RRB- cord-015306-us58wwmp 547 14 of of IN cord-015306-us58wwmp 547 15 center center NN cord-015306-us58wwmp 547 16 of of IN cord-015306-us58wwmp 547 17 pressure pressure NN cord-015306-us58wwmp 547 18 displacement displacement NN cord-015306-us58wwmp 547 19 ( ( -LRB- cord-015306-us58wwmp 547 20 CoP cop NN cord-015306-us58wwmp 547 21 ) ) -RRB- cord-015306-us58wwmp 547 22 . . . cord-015306-us58wwmp 548 1 Student student NN cord-015306-us58wwmp 548 2 t t NN cord-015306-us58wwmp 548 3 - - HYPH cord-015306-us58wwmp 548 4 tests test NNS cord-015306-us58wwmp 548 5 were be VBD cord-015306-us58wwmp 548 6 used use VBN cord-015306-us58wwmp 548 7 to to TO cord-015306-us58wwmp 548 8 compare compare VB cord-015306-us58wwmp 548 9 variables variable NNS cord-015306-us58wwmp 548 10 between between IN cord-015306-us58wwmp 548 11 groups group NNS cord-015306-us58wwmp 548 12 for for IN cord-015306-us58wwmp 548 13 each each DT cord-015306-us58wwmp 548 14 sensorial sensorial JJ cord-015306-us58wwmp 548 15 condition condition NN cord-015306-us58wwmp 548 16 . . . cord-015306-us58wwmp 549 1 The the DT cord-015306-us58wwmp 549 2 level level NN cord-015306-us58wwmp 549 3 of of IN cord-015306-us58wwmp 549 4 significance significance NN cord-015306-us58wwmp 549 5 was be VBD cord-015306-us58wwmp 549 6 95 95 CD cord-015306-us58wwmp 549 7 % % NN cord-015306-us58wwmp 549 8 for for IN cord-015306-us58wwmp 549 9 all all PDT cord-015306-us58wwmp 549 10 the the DT cord-015306-us58wwmp 549 11 analysis analysis NN cord-015306-us58wwmp 549 12 . . . cord-015306-us58wwmp 550 1 Results result NNS cord-015306-us58wwmp 550 2 : : : cord-015306-us58wwmp 551 1 When when WRB cord-015306-us58wwmp 551 2 compared compare VBN cord-015306-us58wwmp 551 3 to to IN cord-015306-us58wwmp 551 4 CG CG NNP cord-015306-us58wwmp 551 5 , , , cord-015306-us58wwmp 551 6 the the DT cord-015306-us58wwmp 551 7 EG EG NNP cord-015306-us58wwmp 551 8 revealed reveal VBD cord-015306-us58wwmp 551 9 larger large JJR cord-015306-us58wwmp 551 10 area area NN cord-015306-us58wwmp 551 11 of of IN cord-015306-us58wwmp 551 12 CoP cop NN cord-015306-us58wwmp 551 13 displacement displacement NN cord-015306-us58wwmp 551 14 in in IN cord-015306-us58wwmp 551 15 the the DT cord-015306-us58wwmp 551 16 condition condition NN cord-015306-us58wwmp 551 17 ( ( -LRB- cord-015306-us58wwmp 551 18 1 1 CD cord-015306-us58wwmp 551 19 ) ) -RRB- cord-015306-us58wwmp 551 20 ( ( -LRB- cord-015306-us58wwmp 551 21 mean± mean± NNP cord-015306-us58wwmp 551 22 SD SD NNP cord-015306-us58wwmp 551 23 of of IN cord-015306-us58wwmp 551 24 2,46±2,11 2,46±2,11 CD cord-015306-us58wwmp 551 25 cm cm NNS cord-015306-us58wwmp 551 26 2 2 CD cord-015306-us58wwmp 551 27 for for IN cord-015306-us58wwmp 551 28 CG CG NNP cord-015306-us58wwmp 551 29 and and CC cord-015306-us58wwmp 551 30 4,16±2,76 4,16±2,76 CD cord-015306-us58wwmp 551 31 cm cm NNS cord-015306-us58wwmp 551 32 2 2 CD cord-015306-us58wwmp 551 33 for for IN cord-015306-us58wwmp 551 34 EG EG NNP cord-015306-us58wwmp 551 35 ; ; : cord-015306-us58wwmp 551 36 p=0,027 p=0,027 NNP cord-015306-us58wwmp 551 37 ) ) -RRB- cord-015306-us58wwmp 551 38 , , , cord-015306-us58wwmp 551 39 and and CC cord-015306-us58wwmp 551 40 in in IN cord-015306-us58wwmp 551 41 condition condition NN cord-015306-us58wwmp 551 42 ( ( -LRB- cord-015306-us58wwmp 551 43 4 4 LS cord-015306-us58wwmp 551 44 ) ) -RRB- cord-015306-us58wwmp 551 45 ( ( -LRB- cord-015306-us58wwmp 551 46 mean± mean± NNP cord-015306-us58wwmp 551 47 SD SD NNP cord-015306-us58wwmp 551 48 of of IN cord-015306-us58wwmp 551 49 4,29±2,45 4,29±2,45 CD cord-015306-us58wwmp 551 50 cm cm NNS cord-015306-us58wwmp 551 51 2 2 CD cord-015306-us58wwmp 551 52 for for IN cord-015306-us58wwmp 551 53 CG CG NNP cord-015306-us58wwmp 551 54 and and CC cord-015306-us58wwmp 551 55 7,33±6,46 7,33±6,46 CD cord-015306-us58wwmp 551 56 cm cm NN cord-015306-us58wwmp 551 57 2 2 CD cord-015306-us58wwmp 551 58 for for IN cord-015306-us58wwmp 551 59 EG EG NNS cord-015306-us58wwmp 551 60 ; ; : cord-015306-us58wwmp 551 61 p=0,05 p=0,05 NNP cord-015306-us58wwmp 551 62 ) ) -RRB- cord-015306-us58wwmp 551 63 . . . cord-015306-us58wwmp 552 1 No no DT cord-015306-us58wwmp 552 2 difference difference NN cord-015306-us58wwmp 552 3 in in IN cord-015306-us58wwmp 552 4 Vm Vm NNP cord-015306-us58wwmp 552 5 were be VBD cord-015306-us58wwmp 552 6 identified identify VBN cord-015306-us58wwmp 552 7 . . . cord-015306-us58wwmp 553 1 Conclusion conclusion NN cord-015306-us58wwmp 553 2 : : : cord-015306-us58wwmp 553 3 When when WRB cord-015306-us58wwmp 553 4 compared compare VBN cord-015306-us58wwmp 553 5 to to IN cord-015306-us58wwmp 553 6 assymptomatic assymptomatic JJ cord-015306-us58wwmp 553 7 control control NN cord-015306-us58wwmp 553 8 group group NN cord-015306-us58wwmp 553 9 , , , cord-015306-us58wwmp 553 10 the the DT cord-015306-us58wwmp 553 11 enuretics enuretic NNS cord-015306-us58wwmp 553 12 children child NNS cord-015306-us58wwmp 553 13 and and CC cord-015306-us58wwmp 553 14 teenagers teenager NNS cord-015306-us58wwmp 553 15 presented present VBD cord-015306-us58wwmp 553 16 larger large JJR cord-015306-us58wwmp 553 17 area area NN cord-015306-us58wwmp 553 18 of of IN cord-015306-us58wwmp 553 19 CoP cop NN cord-015306-us58wwmp 553 20 displacement displacement NN cord-015306-us58wwmp 553 21 under under IN cord-015306-us58wwmp 553 22 normal normal JJ cord-015306-us58wwmp 553 23 sensorial sensorial JJ cord-015306-us58wwmp 553 24 input input NN cord-015306-us58wwmp 553 25 ( ( -LRB- cord-015306-us58wwmp 553 26 condition condition NN cord-015306-us58wwmp 553 27 1 1 CD cord-015306-us58wwmp 553 28 ) ) -RRB- cord-015306-us58wwmp 553 29 and and CC cord-015306-us58wwmp 553 30 when when WRB cord-015306-us58wwmp 553 31 vestibular vestibular JJ cord-015306-us58wwmp 553 32 input input NN cord-015306-us58wwmp 553 33 alone alone RB cord-015306-us58wwmp 553 34 was be VBD cord-015306-us58wwmp 553 35 offered offer VBN cord-015306-us58wwmp 553 36 ( ( -LRB- cord-015306-us58wwmp 553 37 condition condition NN cord-015306-us58wwmp 553 38 4 4 CD cord-015306-us58wwmp 553 39 ) ) -RRB- cord-015306-us58wwmp 553 40 . . . cord-015306-us58wwmp 554 1 The the DT cord-015306-us58wwmp 554 2 hip hip NN cord-015306-us58wwmp 554 3 and and CC cord-015306-us58wwmp 554 4 spine spine NN cord-015306-us58wwmp 554 5 mobility mobility NN cord-015306-us58wwmp 554 6 is be VBZ cord-015306-us58wwmp 554 7 diminished diminish VBN cord-015306-us58wwmp 554 8 in in IN cord-015306-us58wwmp 554 9 enuretic enuretic JJ cord-015306-us58wwmp 554 10 children child NNS cord-015306-us58wwmp 554 11 and and CC cord-015306-us58wwmp 554 12 teenagers teenager NNS cord-015306-us58wwmp 554 13 Rita Rita NNP cord-015306-us58wwmp 554 14 Pavione Pavione NNP cord-015306-us58wwmp 554 15 Rodrigues Rodrigues NNP cord-015306-us58wwmp 554 16 Pereira Pereira NNP cord-015306-us58wwmp 554 17 1 1 CD cord-015306-us58wwmp 554 18 , , , cord-015306-us58wwmp 554 19 Vera Vera NNP cord-015306-us58wwmp 554 20 Herminakalika Herminakalika NNP cord-015306-us58wwmp 554 21 Koch Koch NNP cord-015306-us58wwmp 554 22 2 2 CD cord-015306-us58wwmp 554 23 , , , cord-015306-us58wwmp 554 24 Monica Monica NNP cord-015306-us58wwmp 554 25 Maria Maria NNP cord-015306-us58wwmp 554 26 Ribeiro Ribeiro NNP cord-015306-us58wwmp 554 27 Goncalves Goncalves NNP cord-015306-us58wwmp 554 28 2 2 CD cord-015306-us58wwmp 554 29 , , , cord-015306-us58wwmp 554 30 Thais Thais NNP cord-015306-us58wwmp 554 31 de de NNP cord-015306-us58wwmp 554 32 Souza Souza NNP cord-015306-us58wwmp 554 33 Milhoratti Milhoratti NNP cord-015306-us58wwmp 554 34 1 1 CD cord-015306-us58wwmp 554 35 , , , cord-015306-us58wwmp 554 36 Daniela Daniela NNP cord-015306-us58wwmp 554 37 Castro Castro NNP cord-015306-us58wwmp 554 38 Pacheco Pacheco NNP cord-015306-us58wwmp 554 39 1 1 CD cord-015306-us58wwmp 554 40 , , , cord-015306-us58wwmp 554 41 Clarice Clarice NNP cord-015306-us58wwmp 554 42 Tanaka Tanaka NNP cord-015306-us58wwmp 554 43 1 1 CD cord-015306-us58wwmp 554 44 1 1 CD cord-015306-us58wwmp 554 45 Physical Physical NNP cord-015306-us58wwmp 554 46 Therapy Therapy NNP cord-015306-us58wwmp 554 47 , , , cord-015306-us58wwmp 554 48 University University NNP cord-015306-us58wwmp 554 49 of of IN cord-015306-us58wwmp 554 50 São São NNP cord-015306-us58wwmp 554 51 Paulo Paulo NNP cord-015306-us58wwmp 554 52 , , , cord-015306-us58wwmp 554 53 São São NNP cord-015306-us58wwmp 554 54 Paulo Paulo NNP cord-015306-us58wwmp 554 55 , , , cord-015306-us58wwmp 554 56 Brazil Brazil NNP cord-015306-us58wwmp 554 57 2 2 CD cord-015306-us58wwmp 554 58 Communication Communication NNP cord-015306-us58wwmp 554 59 Disorders Disorders NNPS cord-015306-us58wwmp 554 60 and and CC cord-015306-us58wwmp 554 61 Occupational Occupational NNP cord-015306-us58wwmp 554 62 Therapy Therapy NNP cord-015306-us58wwmp 554 63 , , , cord-015306-us58wwmp 554 64 University University NNP cord-015306-us58wwmp 554 65 of of IN cord-015306-us58wwmp 554 66 São São NNP cord-015306-us58wwmp 554 67 Paulo Paulo NNP cord-015306-us58wwmp 554 68 , , , cord-015306-us58wwmp 554 69 São São NNP cord-015306-us58wwmp 554 70 Paulo Paulo NNP cord-015306-us58wwmp 555 1 , , , cord-015306-us58wwmp 555 2 Brazil Brazil NNP cord-015306-us58wwmp 555 3 Objective Objective NNP cord-015306-us58wwmp 555 4 : : : cord-015306-us58wwmp 556 1 To to TO cord-015306-us58wwmp 556 2 assess assess VB cord-015306-us58wwmp 556 3 the the DT cord-015306-us58wwmp 556 4 hip hip NN cord-015306-us58wwmp 556 5 and and CC cord-015306-us58wwmp 556 6 spine spine NN cord-015306-us58wwmp 556 7 mobility mobility NN cord-015306-us58wwmp 556 8 in in IN cord-015306-us58wwmp 556 9 children child NNS cord-015306-us58wwmp 556 10 and and CC cord-015306-us58wwmp 556 11 enuretic enuretic JJ cord-015306-us58wwmp 556 12 teenagers teenager NNS cord-015306-us58wwmp 556 13 compared compare VBN cord-015306-us58wwmp 556 14 to to IN cord-015306-us58wwmp 556 15 a a DT cord-015306-us58wwmp 556 16 control control NN cord-015306-us58wwmp 556 17 group group NN cord-015306-us58wwmp 556 18 . . . cord-015306-us58wwmp 557 1 Methods method NNS cord-015306-us58wwmp 557 2 : : : cord-015306-us58wwmp 557 3 22 22 CD cord-015306-us58wwmp 557 4 enuretic enuretic NN cord-015306-us58wwmp 557 5 ( ( -LRB- cord-015306-us58wwmp 557 6 EG EG NNP cord-015306-us58wwmp 557 7 ) ) -RRB- cord-015306-us58wwmp 557 8 patients patient NNS cord-015306-us58wwmp 557 9 ( ( -LRB- cord-015306-us58wwmp 557 10 11 11 CD cord-015306-us58wwmp 557 11 boys boy NNS cord-015306-us58wwmp 557 12 and and CC cord-015306-us58wwmp 557 13 11 11 CD cord-015306-us58wwmp 557 14 girls girl NNS cord-015306-us58wwmp 557 15 ) ) -RRB- cord-015306-us58wwmp 557 16 with with IN cord-015306-us58wwmp 557 17 mean mean NNP cord-015306-us58wwmp 557 18 ± ± NNP cord-015306-us58wwmp 557 19 SD SD NNP cord-015306-us58wwmp 557 20 of of IN cord-015306-us58wwmp 557 21 10.52±2.77 10.52±2.77 CD cord-015306-us58wwmp 557 22 years year NNS cord-015306-us58wwmp 557 23 , , , cord-015306-us58wwmp 557 24 ranging range VBG cord-015306-us58wwmp 557 25 from from IN cord-015306-us58wwmp 557 26 7 7 CD cord-015306-us58wwmp 557 27 to to TO cord-015306-us58wwmp 557 28 16 16 CD cord-015306-us58wwmp 557 29 years year NNS cord-015306-us58wwmp 557 30 old old JJ cord-015306-us58wwmp 557 31 , , , cord-015306-us58wwmp 557 32 and and CC cord-015306-us58wwmp 557 33 19.39±3.50 19.39±3.50 CD cord-015306-us58wwmp 557 34 of of IN cord-015306-us58wwmp 557 35 BMI BMI NNP cord-015306-us58wwmp 557 36 were be VBD cord-015306-us58wwmp 557 37 paired pair VBN cord-015306-us58wwmp 557 38 with with IN cord-015306-us58wwmp 557 39 assyntomatic assyntomatic JJ cord-015306-us58wwmp 557 40 kids kid NNS cord-015306-us58wwmp 557 41 ( ( -LRB- cord-015306-us58wwmp 557 42 CG CG NNP cord-015306-us58wwmp 557 43 ) ) -RRB- cord-015306-us58wwmp 557 44 of of IN cord-015306-us58wwmp 557 45 equal equal JJ cord-015306-us58wwmp 557 46 age age NN cord-015306-us58wwmp 557 47 , , , cord-015306-us58wwmp 557 48 gender gender NN cord-015306-us58wwmp 557 49 and and CC cord-015306-us58wwmp 557 50 BMI bmi NN cord-015306-us58wwmp 557 51 . . . cord-015306-us58wwmp 558 1 The the DT cord-015306-us58wwmp 558 2 range range NN cord-015306-us58wwmp 558 3 of of IN cord-015306-us58wwmp 558 4 motion motion NN cord-015306-us58wwmp 558 5 of of IN cord-015306-us58wwmp 558 6 hip hip NN cord-015306-us58wwmp 558 7 flexion flexion NN cord-015306-us58wwmp 558 8 and and CC cord-015306-us58wwmp 558 9 extension extension NN cord-015306-us58wwmp 558 10 was be VBD cord-015306-us58wwmp 558 11 measured measure VBN cord-015306-us58wwmp 558 12 using use VBG cord-015306-us58wwmp 558 13 a a DT cord-015306-us58wwmp 558 14 goniometer goniometer NN cord-015306-us58wwmp 558 15 . . . cord-015306-us58wwmp 559 1 Spine spine NN cord-015306-us58wwmp 559 2 flexibility flexibility NN cord-015306-us58wwmp 559 3 was be VBD cord-015306-us58wwmp 559 4 measured measure VBN cord-015306-us58wwmp 559 5 using use VBG cord-015306-us58wwmp 559 6 Schober Schober NNP cord-015306-us58wwmp 559 7 e e NNP cord-015306-us58wwmp 559 8 Stibor Stibor NNP cord-015306-us58wwmp 559 9 test test NN cord-015306-us58wwmp 559 10 and and CC cord-015306-us58wwmp 559 11 bank bank NN cord-015306-us58wwmp 559 12 of of IN cord-015306-us58wwmp 559 13 wells well NNS cord-015306-us58wwmp 559 14 . . . cord-015306-us58wwmp 560 1 Student student NN cord-015306-us58wwmp 560 2 t t NN cord-015306-us58wwmp 560 3 - - HYPH cord-015306-us58wwmp 560 4 tests test NNS cord-015306-us58wwmp 560 5 were be VBD cord-015306-us58wwmp 560 6 used use VBN cord-015306-us58wwmp 560 7 to to TO cord-015306-us58wwmp 560 8 compare compare VB cord-015306-us58wwmp 560 9 variables variable NNS cord-015306-us58wwmp 560 10 between between IN cord-015306-us58wwmp 560 11 groups group NNS cord-015306-us58wwmp 560 12 . . . cord-015306-us58wwmp 561 1 The the DT cord-015306-us58wwmp 561 2 level level NN cord-015306-us58wwmp 561 3 of of IN cord-015306-us58wwmp 561 4 significance significance NN cord-015306-us58wwmp 561 5 was be VBD cord-015306-us58wwmp 561 6 95 95 CD cord-015306-us58wwmp 561 7 % % NN cord-015306-us58wwmp 561 8 for for IN cord-015306-us58wwmp 561 9 all all PDT cord-015306-us58wwmp 561 10 the the DT cord-015306-us58wwmp 561 11 analysis analysis NN cord-015306-us58wwmp 561 12 . . . cord-015306-us58wwmp 562 1 Results result NNS cord-015306-us58wwmp 562 2 : : : cord-015306-us58wwmp 563 1 When when WRB cord-015306-us58wwmp 563 2 compared compare VBN cord-015306-us58wwmp 563 3 to to IN cord-015306-us58wwmp 563 4 CG CG NNP cord-015306-us58wwmp 563 5 , , , cord-015306-us58wwmp 563 6 the the DT cord-015306-us58wwmp 563 7 EG EG NNP cord-015306-us58wwmp 563 8 revealed reveal VBD cord-015306-us58wwmp 563 9 diminished diminished JJ cord-015306-us58wwmp 563 10 range range NN cord-015306-us58wwmp 563 11 of of IN cord-015306-us58wwmp 563 12 motion motion NN cord-015306-us58wwmp 563 13 of of IN cord-015306-us58wwmp 563 14 hip hip NN cord-015306-us58wwmp 563 15 extension extension NN cord-015306-us58wwmp 563 16 bilaterally bilaterally RB cord-015306-us58wwmp 563 17 ( ( -LRB- cord-015306-us58wwmp 563 18 2±3.89 2±3.89 JJ cord-015306-us58wwmp 563 19 for for IN cord-015306-us58wwmp 563 20 EG EG NNP cord-015306-us58wwmp 563 21 and and CC cord-015306-us58wwmp 563 22 10±7.99 10±7.99 CD cord-015306-us58wwmp 563 23 for for IN cord-015306-us58wwmp 563 24 CG CG NNP cord-015306-us58wwmp 563 25 at at IN cord-015306-us58wwmp 563 26 right right JJ cord-015306-us58wwmp 563 27 side side NN cord-015306-us58wwmp 563 28 ; ; : cord-015306-us58wwmp 563 29 p<0.01 p<0.01 NN cord-015306-us58wwmp 563 30 ; ; : cord-015306-us58wwmp 563 31 GE GE NNP cord-015306-us58wwmp 563 32 2.05±3.88 2.05±3.88 NNP cord-015306-us58wwmp 563 33 for for IN cord-015306-us58wwmp 563 34 EG EG NNP cord-015306-us58wwmp 563 35 and and CC cord-015306-us58wwmp 563 36 10.4±7.22 10.4±7.22 CD cord-015306-us58wwmp 563 37 for for IN cord-015306-us58wwmp 563 38 CG CG NNP cord-015306-us58wwmp 563 39 at at IN cord-015306-us58wwmp 563 40 left left JJ cord-015306-us58wwmp 563 41 side side NN cord-015306-us58wwmp 563 42 ; ; : cord-015306-us58wwmp 563 43 p<0.01 p<0.01 NNP cord-015306-us58wwmp 563 44 ) ) -RRB- cord-015306-us58wwmp 563 45 . . . cord-015306-us58wwmp 564 1 No no DT cord-015306-us58wwmp 564 2 difference difference NN cord-015306-us58wwmp 564 3 was be VBD cord-015306-us58wwmp 564 4 found find VBN cord-015306-us58wwmp 564 5 for for IN cord-015306-us58wwmp 564 6 hip hip NN cord-015306-us58wwmp 564 7 flexion flexion NN cord-015306-us58wwmp 564 8 range range NN cord-015306-us58wwmp 564 9 of of IN cord-015306-us58wwmp 564 10 motion motion NN cord-015306-us58wwmp 564 11 , , , cord-015306-us58wwmp 564 12 however however RB cord-015306-us58wwmp 564 13 compared compare VBN cord-015306-us58wwmp 564 14 to to IN cord-015306-us58wwmp 564 15 CG CG NNP cord-015306-us58wwmp 564 16 , , , cord-015306-us58wwmp 564 17 EG EG NNP cord-015306-us58wwmp 564 18 showed show VBD cord-015306-us58wwmp 564 19 lower low JJR cord-015306-us58wwmp 564 20 values value NNS cord-015306-us58wwmp 564 21 bilaterally bilaterally RB cord-015306-us58wwmp 564 22 ( ( -LRB- cord-015306-us58wwmp 565 1 94.9±17.1 94.9±17.1 LS cord-015306-us58wwmp 565 2 for for IN cord-015306-us58wwmp 565 3 EG EG NNP cord-015306-us58wwmp 565 4 and and CC cord-015306-us58wwmp 565 5 100.32±8.52 100.32±8.52 CD cord-015306-us58wwmp 565 6 for for IN cord-015306-us58wwmp 565 7 CG CG NNP cord-015306-us58wwmp 565 8 at at IN cord-015306-us58wwmp 565 9 right right JJ cord-015306-us58wwmp 565 10 side side NN cord-015306-us58wwmp 565 11 ; ; : cord-015306-us58wwmp 565 12 98.3±11.7 98.3±11.7 CD cord-015306-us58wwmp 565 13 for for IN cord-015306-us58wwmp 565 14 EG EG NNP cord-015306-us58wwmp 565 15 and and CC cord-015306-us58wwmp 565 16 101±11.1 101±11.1 CD cord-015306-us58wwmp 565 17 for for IN cord-015306-us58wwmp 565 18 CG CG NNP cord-015306-us58wwmp 565 19 at at IN cord-015306-us58wwmp 565 20 left left JJ cord-015306-us58wwmp 565 21 side side NN cord-015306-us58wwmp 565 22 ) ) -RRB- cord-015306-us58wwmp 565 23 . . . cord-015306-us58wwmp 566 1 The the DT cord-015306-us58wwmp 566 2 spine spine NN cord-015306-us58wwmp 566 3 flexibility flexibility NN cord-015306-us58wwmp 566 4 did do VBD cord-015306-us58wwmp 566 5 not not RB cord-015306-us58wwmp 566 6 presente presente VB cord-015306-us58wwmp 566 7 any any DT cord-015306-us58wwmp 566 8 difference difference NN cord-015306-us58wwmp 566 9 for for IN cord-015306-us58wwmp 566 10 Schober Schober NNP cord-015306-us58wwmp 566 11 ( ( -LRB- cord-015306-us58wwmp 566 12 14.88±3.18 14.88±3.18 CD cord-015306-us58wwmp 566 13 for for IN cord-015306-us58wwmp 566 14 EG EG NNP cord-015306-us58wwmp 566 15 and and CC cord-015306-us58wwmp 566 16 16.18±1.16 16.18±1.16 CD cord-015306-us58wwmp 566 17 for for IN cord-015306-us58wwmp 566 18 CG CG NNP cord-015306-us58wwmp 566 19 ; ; : cord-015306-us58wwmp 566 20 p p NN cord-015306-us58wwmp 566 21 = = SYM cord-015306-us58wwmp 566 22 0.07 0.07 CD cord-015306-us58wwmp 566 23 ) ) -RRB- cord-015306-us58wwmp 566 24 , , , cord-015306-us58wwmp 566 25 and and CC cord-015306-us58wwmp 566 26 Stibor Stibor NNP cord-015306-us58wwmp 566 27 ( ( -LRB- cord-015306-us58wwmp 566 28 50.21±6.2 50.21±6.2 CD cord-015306-us58wwmp 566 29 for for IN cord-015306-us58wwmp 566 30 EG EG NNP cord-015306-us58wwmp 566 31 and and CC cord-015306-us58wwmp 566 32 51.93±7.37 51.93±7.37 CD cord-015306-us58wwmp 566 33 for for IN cord-015306-us58wwmp 566 34 CG CG NNP cord-015306-us58wwmp 566 35 ; ; : cord-015306-us58wwmp 566 36 p=0.40 p=0.40 NNP cord-015306-us58wwmp 566 37 ) ) -RRB- cord-015306-us58wwmp 566 38 and and CC cord-015306-us58wwmp 566 39 bank bank NNP cord-015306-us58wwmp 566 40 of of IN cord-015306-us58wwmp 566 41 wells wells NNP cord-015306-us58wwmp 566 42 ( ( -LRB- cord-015306-us58wwmp 566 43 25.58±7.67 25.58±7.67 CD cord-015306-us58wwmp 566 44 for for IN cord-015306-us58wwmp 566 45 and and CC cord-015306-us58wwmp 566 46 23.66±7.42 23.66±7.42 CD cord-015306-us58wwmp 566 47 for for IN cord-015306-us58wwmp 566 48 CG CG NNP cord-015306-us58wwmp 566 49 ; ; : cord-015306-us58wwmp 566 50 p=0.63 p=0.63 NNP cord-015306-us58wwmp 566 51 ) ) -RRB- cord-015306-us58wwmp 566 52 . . . cord-015306-us58wwmp 567 1 Conclusion conclusion NN cord-015306-us58wwmp 567 2 : : : cord-015306-us58wwmp 567 3 When when WRB cord-015306-us58wwmp 567 4 compared compare VBN cord-015306-us58wwmp 567 5 to to IN cord-015306-us58wwmp 567 6 assymptomatic assymptomatic JJ cord-015306-us58wwmp 567 7 control control NN cord-015306-us58wwmp 567 8 group group NN cord-015306-us58wwmp 567 9 , , , cord-015306-us58wwmp 567 10 the the DT cord-015306-us58wwmp 567 11 enuretics enuretic NNS cord-015306-us58wwmp 567 12 children child NNS cord-015306-us58wwmp 567 13 and and CC cord-015306-us58wwmp 567 14 teenagers teenager NNS cord-015306-us58wwmp 567 15 presented present VBD cord-015306-us58wwmp 567 16 diminished diminished JJ cord-015306-us58wwmp 567 17 range range NN cord-015306-us58wwmp 567 18 of of IN cord-015306-us58wwmp 567 19 motion motion NN cord-015306-us58wwmp 567 20 of of IN cord-015306-us58wwmp 567 21 hip hip NN cord-015306-us58wwmp 567 22 extension extension NN cord-015306-us58wwmp 567 23 suggesting suggest VBG cord-015306-us58wwmp 567 24 transversal transversal JJ cord-015306-us58wwmp 567 25 misalignment misalignment NN cord-015306-us58wwmp 567 26 of of IN cord-015306-us58wwmp 567 27 the the DT cord-015306-us58wwmp 567 28 pelvis pelvi NNS cord-015306-us58wwmp 567 29 . . . cord-015306-us58wwmp 568 1 More More JJR cord-015306-us58wwmp 568 2 concern concern NN cord-015306-us58wwmp 568 3 about about IN cord-015306-us58wwmp 568 4 enuresis enuresis NN cord-015306-us58wwmp 568 5 children child NNS cord-015306-us58wwmp 568 6 : : : cord-015306-us58wwmp 568 7 an an DT cord-015306-us58wwmp 568 8 epidemiological epidemiological JJ cord-015306-us58wwmp 568 9 study study NN cord-015306-us58wwmp 568 10 of of IN cord-015306-us58wwmp 568 11 primary primary JJ cord-015306-us58wwmp 568 12 nocturnal nocturnal JJ cord-015306-us58wwmp 568 13 enuresis enuresis NN cord-015306-us58wwmp 568 14 in in IN cord-015306-us58wwmp 568 15 elementary elementary JJ cord-015306-us58wwmp 568 16 schools school NNS cord-015306-us58wwmp 568 17 in in IN cord-015306-us58wwmp 568 18 Shanghai Shanghai NNP cord-015306-us58wwmp 568 19 Yibing Yibing NNP cord-015306-us58wwmp 568 20 Zheng Zheng NNP cord-015306-us58wwmp 568 21 1 1 CD cord-015306-us58wwmp 568 22 , , , cord-015306-us58wwmp 568 23 Yinv Yinv NNP cord-015306-us58wwmp 568 24 Gong Gong NNP cord-015306-us58wwmp 568 25 1 1 CD cord-015306-us58wwmp 568 26 , , , cord-015306-us58wwmp 568 27 Hong Hong NNP cord-015306-us58wwmp 568 28 Xu Xu NNP cord-015306-us58wwmp 568 29 1 1 CD cord-015306-us58wwmp 568 30 , , , cord-015306-us58wwmp 568 31 Keli Keli NNP cord-015306-us58wwmp 568 32 Wang Wang NNP cord-015306-us58wwmp 568 33 1 1 CD cord-015306-us58wwmp 568 34 , , , cord-015306-us58wwmp 568 35 2 2 CD cord-015306-us58wwmp 568 36 , , , cord-015306-us58wwmp 568 37 Zhonghui Zhonghui NNP cord-015306-us58wwmp 568 38 Ni Ni NNP cord-015306-us58wwmp 568 39 1,2 1,2 CD cord-015306-us58wwmp 568 40 , , , cord-015306-us58wwmp 569 1 Dandan Dandan NNP cord-015306-us58wwmp 569 2 He -PRON- PRP cord-015306-us58wwmp 570 1 1,3 1,3 CD cord-015306-us58wwmp 570 2 1 1 CD cord-015306-us58wwmp 570 3 Nephrology Nephrology NNP cord-015306-us58wwmp 570 4 and and CC cord-015306-us58wwmp 570 5 Rheumatism Rheumatism NNP cord-015306-us58wwmp 570 6 , , , cord-015306-us58wwmp 570 7 Shanghai Shanghai NNP cord-015306-us58wwmp 570 8 , , , cord-015306-us58wwmp 570 9 China China NNP cord-015306-us58wwmp 570 10 2 2 CD cord-015306-us58wwmp 570 11 Xuhui Xuhui NNP cord-015306-us58wwmp 570 12 Health Health NNP cord-015306-us58wwmp 570 13 Bureau Bureau NNP cord-015306-us58wwmp 570 14 , , , cord-015306-us58wwmp 570 15 Shanghai Shanghai NNP cord-015306-us58wwmp 570 16 , , , cord-015306-us58wwmp 570 17 China China NNP cord-015306-us58wwmp 570 18 3 3 CD cord-015306-us58wwmp 570 19 Minhang Minhang NNP cord-015306-us58wwmp 570 20 Center Center NNP cord-015306-us58wwmp 570 21 for for IN cord-015306-us58wwmp 570 22 Disease Disease NNP cord-015306-us58wwmp 570 23 Control Control NNP cord-015306-us58wwmp 570 24 and and CC cord-015306-us58wwmp 570 25 Prevention Prevention NNP cord-015306-us58wwmp 570 26 , , , cord-015306-us58wwmp 570 27 Shanghai Shanghai NNP cord-015306-us58wwmp 571 1 , , , cord-015306-us58wwmp 571 2 China China NNP cord-015306-us58wwmp 571 3 Objective Objective NNP cord-015306-us58wwmp 571 4 : : : cord-015306-us58wwmp 571 5 ( ( -LRB- cord-015306-us58wwmp 571 6 1 1 LS cord-015306-us58wwmp 571 7 ) ) -RRB- cord-015306-us58wwmp 571 8 To to TO cord-015306-us58wwmp 571 9 assess assess VB cord-015306-us58wwmp 571 10 the the DT cord-015306-us58wwmp 571 11 prevalence prevalence NN cord-015306-us58wwmp 571 12 of of IN cord-015306-us58wwmp 571 13 primary primary JJ cord-015306-us58wwmp 571 14 nocturnal nocturnal JJ cord-015306-us58wwmp 571 15 enuresis enuresis NN cord-015306-us58wwmp 571 16 ( ( -LRB- cord-015306-us58wwmp 571 17 PNE PNE NNP cord-015306-us58wwmp 571 18 ) ) -RRB- cord-015306-us58wwmp 571 19 and and CC cord-015306-us58wwmp 571 20 its -PRON- PRP$ cord-015306-us58wwmp 571 21 risk risk NN cord-015306-us58wwmp 571 22 factors factor NNS cord-015306-us58wwmp 571 23 in in IN cord-015306-us58wwmp 571 24 children child NNS cord-015306-us58wwmp 571 25 of of IN cord-015306-us58wwmp 571 26 elementary elementary JJ cord-015306-us58wwmp 571 27 school school NN cord-015306-us58wwmp 571 28 age age NN cord-015306-us58wwmp 571 29 in in IN cord-015306-us58wwmp 571 30 Shanghai Shanghai NNP cord-015306-us58wwmp 571 31 . . . cord-015306-us58wwmp 572 1 ( ( -LRB- cord-015306-us58wwmp 572 2 2 2 LS cord-015306-us58wwmp 572 3 ) ) -RRB- cord-015306-us58wwmp 572 4 To to TO cord-015306-us58wwmp 572 5 evaluate evaluate VB cord-015306-us58wwmp 572 6 the the DT cord-015306-us58wwmp 572 7 impact impact NN cord-015306-us58wwmp 572 8 of of IN cord-015306-us58wwmp 572 9 enuresis enuresis NN cord-015306-us58wwmp 572 10 on on IN cord-015306-us58wwmp 572 11 these these DT cord-015306-us58wwmp 572 12 children child NNS cord-015306-us58wwmp 572 13 and and CC cord-015306-us58wwmp 572 14 their -PRON- PRP$ cord-015306-us58wwmp 572 15 parents parent NNS cord-015306-us58wwmp 572 16 , , , cord-015306-us58wwmp 572 17 and and CC cord-015306-us58wwmp 572 18 to to TO cord-015306-us58wwmp 572 19 identify identify VB cord-015306-us58wwmp 572 20 the the DT cord-015306-us58wwmp 572 21 methods method NNS cord-015306-us58wwmp 572 22 and and CC cord-015306-us58wwmp 572 23 effectiveness effectiveness NN cord-015306-us58wwmp 572 24 of of IN cord-015306-us58wwmp 572 25 managing manage VBG cord-015306-us58wwmp 572 26 enuresis enuresis NN cord-015306-us58wwmp 572 27 . . . cord-015306-us58wwmp 573 1 Methods method NNS cord-015306-us58wwmp 573 2 : : : cord-015306-us58wwmp 574 1 A a DT cord-015306-us58wwmp 574 2 randomly randomly RB cord-015306-us58wwmp 574 3 selected select VBN cord-015306-us58wwmp 574 4 cross cross JJ cord-015306-us58wwmp 574 5 - - JJ cord-015306-us58wwmp 574 6 sectional sectional JJ cord-015306-us58wwmp 574 7 study study NN cord-015306-us58wwmp 574 8 was be VBD cord-015306-us58wwmp 574 9 conducted conduct VBN cord-015306-us58wwmp 574 10 in in IN cord-015306-us58wwmp 574 11 four four CD cord-015306-us58wwmp 574 12 elementary elementary JJ cord-015306-us58wwmp 574 13 schools school NNS cord-015306-us58wwmp 574 14 in in IN cord-015306-us58wwmp 574 15 two two CD cord-015306-us58wwmp 574 16 districts district NNS cord-015306-us58wwmp 574 17 inShanghai inShanghai NNP cord-015306-us58wwmp 574 18 . . . cord-015306-us58wwmp 575 1 The the DT cord-015306-us58wwmp 575 2 parents parent NNS cord-015306-us58wwmp 575 3 of of IN cord-015306-us58wwmp 575 4 these these DT cord-015306-us58wwmp 575 5 children child NNS cord-015306-us58wwmp 575 6 were be VBD cord-015306-us58wwmp 575 7 asked ask VBN cord-015306-us58wwmp 575 8 to to TO cord-015306-us58wwmp 575 9 complete complete VB cord-015306-us58wwmp 575 10 questionnaires questionnaire NNS cord-015306-us58wwmp 575 11 anonymously anonymously RB cord-015306-us58wwmp 575 12 which which WDT cord-015306-us58wwmp 575 13 included include VBD cord-015306-us58wwmp 575 14 items item NNS cord-015306-us58wwmp 575 15 about about IN cord-015306-us58wwmp 575 16 the the DT cord-015306-us58wwmp 575 17 presence presence NN cord-015306-us58wwmp 575 18 and and CC cord-015306-us58wwmp 575 19 frequency frequency NN cord-015306-us58wwmp 575 20 of of IN cord-015306-us58wwmp 575 21 enuresis enuresis NN cord-015306-us58wwmp 575 22 , , , cord-015306-us58wwmp 575 23 its -PRON- PRP$ cord-015306-us58wwmp 575 24 risk risk NN cord-015306-us58wwmp 575 25 factors factor NNS cord-015306-us58wwmp 575 26 and and CC cord-015306-us58wwmp 575 27 its -PRON- PRP$ cord-015306-us58wwmp 575 28 perceived perceive VBN cord-015306-us58wwmp 575 29 impact impact NN cord-015306-us58wwmp 575 30 and and CC cord-015306-us58wwmp 575 31 management management NN cord-015306-us58wwmp 575 32 . . . cord-015306-us58wwmp 576 1 The the DT cord-015306-us58wwmp 576 2 distress distress NN cord-015306-us58wwmp 576 3 caused cause VBN cord-015306-us58wwmp 576 4 to to IN cord-015306-us58wwmp 576 5 the the DT cord-015306-us58wwmp 576 6 family family NN cord-015306-us58wwmp 576 7 by by IN cord-015306-us58wwmp 576 8 enuresis enuresis NN cord-015306-us58wwmp 576 9 and and CC cord-015306-us58wwmp 576 10 the the DT cord-015306-us58wwmp 576 11 outcome outcome NN cord-015306-us58wwmp 576 12 of of IN cord-015306-us58wwmp 576 13 any any DT cord-015306-us58wwmp 576 14 management management NN cord-015306-us58wwmp 576 15 was be VBD cord-015306-us58wwmp 576 16 evaluated evaluate VBN cord-015306-us58wwmp 576 17 using use VBG cord-015306-us58wwmp 576 18 a a DT cord-015306-us58wwmp 576 19 5-point 5-point CD cord-015306-us58wwmp 576 20 visual visual JJ cord-015306-us58wwmp 576 21 analogue analogue NN cord-015306-us58wwmp 576 22 scale scale NN cord-015306-us58wwmp 576 23 ( ( -LRB- cord-015306-us58wwmp 576 24 VAS VAS NNP cord-015306-us58wwmp 576 25 ) ) -RRB- cord-015306-us58wwmp 576 26 . . . cord-015306-us58wwmp 577 1 PNS PNS NNP cord-015306-us58wwmp 577 2 was be VBD cord-015306-us58wwmp 577 3 defined define VBN cord-015306-us58wwmp 577 4 as as IN cord-015306-us58wwmp 577 5 an an DT cord-015306-us58wwmp 577 6 involuntary involuntary JJ cord-015306-us58wwmp 577 7 voiding voiding NN cord-015306-us58wwmp 577 8 of of IN cord-015306-us58wwmp 577 9 urine urine NN cord-015306-us58wwmp 577 10 during during IN cord-015306-us58wwmp 577 11 sleep sleep NN cord-015306-us58wwmp 577 12 , , , cord-015306-us58wwmp 577 13 with with IN cord-015306-us58wwmp 577 14 a a DT cord-015306-us58wwmp 577 15 frequency frequency NN cord-015306-us58wwmp 577 16 of of IN cord-015306-us58wwmp 577 17 more more JJR cord-015306-us58wwmp 577 18 than than IN cord-015306-us58wwmp 577 19 two two CD cord-015306-us58wwmp 577 20 times time NNS cord-015306-us58wwmp 577 21 a a DT cord-015306-us58wwmp 577 22 week week NN cord-015306-us58wwmp 577 23 for for IN cord-015306-us58wwmp 577 24 three three CD cord-015306-us58wwmp 577 25 consecutive consecutive JJ cord-015306-us58wwmp 577 26 months month NNS cord-015306-us58wwmp 577 27 , , , cord-015306-us58wwmp 577 28 in in IN cord-015306-us58wwmp 577 29 the the DT cord-015306-us58wwmp 577 30 absence absence NN cord-015306-us58wwmp 577 31 of of IN cord-015306-us58wwmp 577 32 congenital congenital JJ cord-015306-us58wwmp 577 33 or or CC cord-015306-us58wwmp 577 34 acquired acquire VBN cord-015306-us58wwmp 577 35 defects defect NNS cord-015306-us58wwmp 577 36 of of IN cord-015306-us58wwmp 577 37 the the DT cord-015306-us58wwmp 577 38 central central JJ cord-015306-us58wwmp 577 39 nervous nervous JJ cord-015306-us58wwmp 577 40 system system NN cord-015306-us58wwmp 577 41 . . . cord-015306-us58wwmp 578 1 Results result NNS cord-015306-us58wwmp 578 2 : : : cord-015306-us58wwmp 579 1 A a DT cord-015306-us58wwmp 579 2 total total NN cord-015306-us58wwmp 579 3 of of IN cord-015306-us58wwmp 579 4 7600 7600 CD cord-015306-us58wwmp 579 5 questionnaires questionnaire NNS cord-015306-us58wwmp 579 6 were be VBD cord-015306-us58wwmp 579 7 distributed distribute VBN cord-015306-us58wwmp 579 8 . . . cord-015306-us58wwmp 580 1 The the DT cord-015306-us58wwmp 580 2 overall overall JJ cord-015306-us58wwmp 580 3 response response NN cord-015306-us58wwmp 580 4 rate rate NN cord-015306-us58wwmp 580 5 to to IN cord-015306-us58wwmp 580 6 the the DT cord-015306-us58wwmp 580 7 questionnaire questionnaire NN cord-015306-us58wwmp 580 8 was be VBD cord-015306-us58wwmp 580 9 97.1 97.1 CD cord-015306-us58wwmp 580 10 % % NN cord-015306-us58wwmp 580 11 , , , cord-015306-us58wwmp 580 12 girls girl NNS cord-015306-us58wwmp 580 13 45.2 45.2 CD cord-015306-us58wwmp 580 14 % % NN cord-015306-us58wwmp 580 15 and and CC cord-015306-us58wwmp 580 16 boys boy NNS cord-015306-us58wwmp 580 17 51.8 51.8 CD cord-015306-us58wwmp 580 18 % % NN cord-015306-us58wwmp 580 19 . . . cord-015306-us58wwmp 581 1 The the DT cord-015306-us58wwmp 581 2 prevalence prevalence NN cord-015306-us58wwmp 581 3 of of IN cord-015306-us58wwmp 581 4 PNE PNE NNP cord-015306-us58wwmp 581 5 declined decline VBD cord-015306-us58wwmp 581 6 with with IN cord-015306-us58wwmp 581 7 age age NN cord-015306-us58wwmp 581 8 from from IN cord-015306-us58wwmp 581 9 6.3 6.3 CD cord-015306-us58wwmp 581 10 % % NN cord-015306-us58wwmp 581 11 at at IN cord-015306-us58wwmp 581 12 7 7 CD cord-015306-us58wwmp 581 13 years year NNS cord-015306-us58wwmp 581 14 old old JJ cord-015306-us58wwmp 581 15 to to IN cord-015306-us58wwmp 581 16 0.5 0.5 CD cord-015306-us58wwmp 581 17 % % NN cord-015306-us58wwmp 581 18 at at IN cord-015306-us58wwmp 581 19 11 11 CD cord-015306-us58wwmp 581 20 years year NNS cord-015306-us58wwmp 581 21 old old JJ cord-015306-us58wwmp 581 22 . . . cord-015306-us58wwmp 582 1 Of of IN cord-015306-us58wwmp 582 2 all all DT cord-015306-us58wwmp 582 3 enuresis enuresis NN cord-015306-us58wwmp 582 4 children child NNS cord-015306-us58wwmp 582 5 , , , cord-015306-us58wwmp 582 6 10.1 10.1 CD cord-015306-us58wwmp 582 7 % % NN cord-015306-us58wwmp 582 8 had have VBD cord-015306-us58wwmp 582 9 daytime daytime JJ cord-015306-us58wwmp 582 10 urinary urinary JJ cord-015306-us58wwmp 582 11 symptoms symptom NNS cord-015306-us58wwmp 582 12 and and CC cord-015306-us58wwmp 582 13 11.7 11.7 CD cord-015306-us58wwmp 582 14 % % NN cord-015306-us58wwmp 582 15 had have VBD cord-015306-us58wwmp 582 16 a a DT cord-015306-us58wwmp 582 17 positive positive JJ cord-015306-us58wwmp 582 18 family family NN cord-015306-us58wwmp 582 19 history history NN cord-015306-us58wwmp 582 20 . . . cord-015306-us58wwmp 583 1 58.8 58.8 CD cord-015306-us58wwmp 583 2 % % NN cord-015306-us58wwmp 583 3 of of IN cord-015306-us58wwmp 583 4 parents parent NNS cord-015306-us58wwmp 583 5 were be VBD cord-015306-us58wwmp 583 6 concerned concerned JJ cord-015306-us58wwmp 583 7 and and CC cord-015306-us58wwmp 583 8 17.6 17.6 CD cord-015306-us58wwmp 583 9 % % NN cord-015306-us58wwmp 583 10 were be VBD cord-015306-us58wwmp 583 11 very very RB cord-015306-us58wwmp 583 12 concerned concerned JJ cord-015306-us58wwmp 583 13 about about IN cord-015306-us58wwmp 583 14 enuresis enuresis NN cord-015306-us58wwmp 583 15 . . . cord-015306-us58wwmp 584 1 41.2 41.2 CD cord-015306-us58wwmp 584 2 % % NN cord-015306-us58wwmp 584 3 of of IN cord-015306-us58wwmp 584 4 children child NNS cord-015306-us58wwmp 584 5 were be VBD cord-015306-us58wwmp 584 6 worried worried JJ cord-015306-us58wwmp 584 7 about about IN cord-015306-us58wwmp 584 8 and and CC cord-015306-us58wwmp 584 9 5.9 5.9 CD cord-015306-us58wwmp 584 10 % % NN cord-015306-us58wwmp 584 11 were be VBD cord-015306-us58wwmp 584 12 very very RB cord-015306-us58wwmp 584 13 worried worried JJ cord-015306-us58wwmp 584 14 about about IN cord-015306-us58wwmp 584 15 enuresis enuresis NN cord-015306-us58wwmp 584 16 . . . cord-015306-us58wwmp 585 1 Only only RB cord-015306-us58wwmp 585 2 35.3 35.3 CD cord-015306-us58wwmp 585 3 % % NN cord-015306-us58wwmp 585 4 of of IN cord-015306-us58wwmp 585 5 PNE PNE NNP cord-015306-us58wwmp 585 6 children child NNS cord-015306-us58wwmp 585 7 sought seek VBD cord-015306-us58wwmp 585 8 for for IN cord-015306-us58wwmp 585 9 treatment treatment NN cord-015306-us58wwmp 585 10 and and CC cord-015306-us58wwmp 585 11 the the DT cord-015306-us58wwmp 585 12 common common JJ cord-015306-us58wwmp 585 13 strategies strategy NNS cord-015306-us58wwmp 585 14 ( ( -LRB- cord-015306-us58wwmp 585 15 23.5 23.5 CD cord-015306-us58wwmp 585 16 % % NN cord-015306-us58wwmp 585 17 ) ) -RRB- cord-015306-us58wwmp 585 18 were be VBD cord-015306-us58wwmp 585 19 adjusting adjust VBG cord-015306-us58wwmp 585 20 lifestyle lifestyle NN cord-015306-us58wwmp 585 21 such such JJ cord-015306-us58wwmp 585 22 as as IN cord-015306-us58wwmp 585 23 restriction restriction NN cord-015306-us58wwmp 585 24 of of IN cord-015306-us58wwmp 585 25 water water NN cord-015306-us58wwmp 585 26 intake intake NN cord-015306-us58wwmp 585 27 at at IN cord-015306-us58wwmp 585 28 night night NN cord-015306-us58wwmp 585 29 , , , cord-015306-us58wwmp 585 30 11.9 11.9 CD cord-015306-us58wwmp 585 31 % % NN cord-015306-us58wwmp 585 32 used use VBN cord-015306-us58wwmp 585 33 alarm alarm NN cord-015306-us58wwmp 585 34 clock clock NN cord-015306-us58wwmp 585 35 and and CC cord-015306-us58wwmp 585 36 5.8 5.8 CD cord-015306-us58wwmp 585 37 % % NN cord-015306-us58wwmp 585 38 were be VBD cord-015306-us58wwmp 585 39 take take VB cord-015306-us58wwmp 585 40 medication medication NN cord-015306-us58wwmp 585 41 . . . cord-015306-us58wwmp 586 1 48.6 48.6 CD cord-015306-us58wwmp 586 2 % % NN cord-015306-us58wwmp 586 3 of of IN cord-015306-us58wwmp 586 4 parents parent NNS cord-015306-us58wwmp 586 5 felt feel VBD cord-015306-us58wwmp 586 6 that that IN cord-015306-us58wwmp 586 7 the the DT cord-015306-us58wwmp 586 8 current current JJ cord-015306-us58wwmp 586 9 treatment treatment NN cord-015306-us58wwmp 586 10 was be VBD cord-015306-us58wwmp 586 11 effective effective JJ cord-015306-us58wwmp 586 12 . . . cord-015306-us58wwmp 587 1 Conclusion conclusion NN cord-015306-us58wwmp 587 2 : : : cord-015306-us58wwmp 587 3 We -PRON- PRP cord-015306-us58wwmp 587 4 conducted conduct VBD cord-015306-us58wwmp 587 5 a a DT cord-015306-us58wwmp 587 6 relatively relatively RB cord-015306-us58wwmp 587 7 scientific scientific JJ cord-015306-us58wwmp 587 8 epidemiological epidemiological JJ cord-015306-us58wwmp 587 9 survey survey NN cord-015306-us58wwmp 587 10 on on IN cord-015306-us58wwmp 587 11 the the DT cord-015306-us58wwmp 587 12 prevalence prevalence NN cord-015306-us58wwmp 587 13 of of IN cord-015306-us58wwmp 587 14 PNE PNE NNP cord-015306-us58wwmp 587 15 in in IN cord-015306-us58wwmp 587 16 two two CD cord-015306-us58wwmp 587 17 districts district NNS cord-015306-us58wwmp 587 18 in in IN cord-015306-us58wwmp 587 19 Shanghai Shanghai NNP cord-015306-us58wwmp 587 20 . . . cord-015306-us58wwmp 588 1 We -PRON- PRP cord-015306-us58wwmp 588 2 find find VBP cord-015306-us58wwmp 588 3 enuresis enuresis NN cord-015306-us58wwmp 588 4 still still RB cord-015306-us58wwmp 588 5 has have VBZ cord-015306-us58wwmp 588 6 great great JJ cord-015306-us58wwmp 588 7 impact impact NN cord-015306-us58wwmp 588 8 on on IN cord-015306-us58wwmp 588 9 children child NNS cord-015306-us58wwmp 588 10 and and CC cord-015306-us58wwmp 588 11 their -PRON- PRP$ cord-015306-us58wwmp 588 12 parents parent NNS cord-015306-us58wwmp 588 13 , , , cord-015306-us58wwmp 588 14 but but CC cord-015306-us58wwmp 588 15 only only RB cord-015306-us58wwmp 588 16 a a DT cord-015306-us58wwmp 588 17 small small JJ cord-015306-us58wwmp 588 18 part part NN cord-015306-us58wwmp 588 19 of of IN cord-015306-us58wwmp 588 20 them -PRON- PRP cord-015306-us58wwmp 588 21 will will MD cord-015306-us58wwmp 588 22 seek seek VB cord-015306-us58wwmp 588 23 for for IN cord-015306-us58wwmp 588 24 treatment treatment NN cord-015306-us58wwmp 588 25 . . . cord-015306-us58wwmp 589 1 And and CC cord-015306-us58wwmp 589 2 only only RB cord-015306-us58wwmp 589 3 half half NN cord-015306-us58wwmp 589 4 of of IN cord-015306-us58wwmp 589 5 the the DT cord-015306-us58wwmp 589 6 parents parent NNS cord-015306-us58wwmp 589 7 feel feel VBP cord-015306-us58wwmp 589 8 that that IN cord-015306-us58wwmp 589 9 the the DT cord-015306-us58wwmp 589 10 current current JJ cord-015306-us58wwmp 589 11 treatment treatment NN cord-015306-us58wwmp 589 12 is be VBZ cord-015306-us58wwmp 589 13 effective effective JJ cord-015306-us58wwmp 589 14 . . . cord-015306-us58wwmp 590 1 Therefore therefore RB cord-015306-us58wwmp 590 2 , , , cord-015306-us58wwmp 590 3 it -PRON- PRP cord-015306-us58wwmp 590 4 would would MD cord-015306-us58wwmp 590 5 be be VB cord-015306-us58wwmp 590 6 desirable desirable JJ cord-015306-us58wwmp 590 7 to to TO cord-015306-us58wwmp 590 8 create create VB cord-015306-us58wwmp 590 9 a a DT cord-015306-us58wwmp 590 10 series series NN cord-015306-us58wwmp 590 11 of of IN cord-015306-us58wwmp 590 12 standardized standardized JJ cord-015306-us58wwmp 590 13 management management NN cord-015306-us58wwmp 590 14 and and CC cord-015306-us58wwmp 590 15 follow follow NN cord-015306-us58wwmp 590 16 - - HYPH cord-015306-us58wwmp 590 17 up up NN cord-015306-us58wwmp 590 18 processes process NNS cord-015306-us58wwmp 590 19 for for IN cord-015306-us58wwmp 590 20 enuresis enuresis NN cord-015306-us58wwmp 590 21 children child NNS cord-015306-us58wwmp 590 22 . . . cord-015306-us58wwmp 591 1 Abstract abstract JJ cord-015306-us58wwmp 591 2 # # NN cord-015306-us58wwmp 591 3 P p NN cord-015306-us58wwmp 591 4 - - HYPH cord-015306-us58wwmp 591 5 SAT068 sat068 JJ cord-015306-us58wwmp 592 1 Renal renal JJ cord-015306-us58wwmp 592 2 manifestations manifestation NNS cord-015306-us58wwmp 592 3 of of IN cord-015306-us58wwmp 592 4 Tuberous Tuberous NNP cord-015306-us58wwmp 592 5 Sclerosis Sclerosis NNP cord-015306-us58wwmp 592 6 : : : cord-015306-us58wwmp 592 7 a a DT cord-015306-us58wwmp 592 8 descriptive descriptive JJ cord-015306-us58wwmp 592 9 analysis analysis NN cord-015306-us58wwmp 592 10 Sophy Sophy NNP cord-015306-us58wwmp 592 11 Korula Korula NNP cord-015306-us58wwmp 592 12 1 1 CD cord-015306-us58wwmp 592 13 , , , cord-015306-us58wwmp 592 14 Alka Alka NNP cord-015306-us58wwmp 592 15 Ekbote Ekbote NNP cord-015306-us58wwmp 592 16 2 2 CD cord-015306-us58wwmp 592 17 , , , cord-015306-us58wwmp 592 18 Naresh Naresh NNP cord-015306-us58wwmp 592 19 Kumar Kumar NNP cord-015306-us58wwmp 592 20 1 1 CD cord-015306-us58wwmp 592 21 , , , cord-015306-us58wwmp 592 22 Sumita Sumita NNP cord-015306-us58wwmp 592 23 Danda Danda NNP cord-015306-us58wwmp 592 24 2 2 CD cord-015306-us58wwmp 592 25 , , , cord-015306-us58wwmp 592 26 Indira Indira NNP cord-015306-us58wwmp 592 27 Agarwal Agarwal NNP cord-015306-us58wwmp 592 28 1 1 CD cord-015306-us58wwmp 592 29 , , , cord-015306-us58wwmp 592 30 Swasti Swasti NNP cord-015306-us58wwmp 592 31 Chaturvedi Chaturvedi NNP cord-015306-us58wwmp 592 32 1 1 CD cord-015306-us58wwmp 592 33 1 1 CD cord-015306-us58wwmp 592 34 Paediatrics Paediatrics NNPS cord-015306-us58wwmp 592 35 , , , cord-015306-us58wwmp 592 36 Christian Christian NNP cord-015306-us58wwmp 592 37 Medical Medical NNP cord-015306-us58wwmp 592 38 College College NNP cord-015306-us58wwmp 592 39 , , , cord-015306-us58wwmp 592 40 Vellore Vellore NNP cord-015306-us58wwmp 592 41 , , , cord-015306-us58wwmp 592 42 India India NNP cord-015306-us58wwmp 592 43 2 2 CD cord-015306-us58wwmp 592 44 Clinical Clinical NNP cord-015306-us58wwmp 592 45 Genetics Genetics NNP cord-015306-us58wwmp 592 46 , , , cord-015306-us58wwmp 592 47 Christian Christian NNP cord-015306-us58wwmp 592 48 Medical Medical NNP cord-015306-us58wwmp 592 49 College College NNP cord-015306-us58wwmp 592 50 , , , cord-015306-us58wwmp 592 51 Vellore Vellore NNP cord-015306-us58wwmp 592 52 , , , cord-015306-us58wwmp 593 1 India India NNP cord-015306-us58wwmp 593 2 Objective Objective NNP cord-015306-us58wwmp 593 3 : : : cord-015306-us58wwmp 593 4 To to TO cord-015306-us58wwmp 593 5 describe describe VB cord-015306-us58wwmp 593 6 the the DT cord-015306-us58wwmp 593 7 renal renal JJ cord-015306-us58wwmp 593 8 manifestations manifestation NNS cord-015306-us58wwmp 593 9 in in IN cord-015306-us58wwmp 593 10 children child NNS cord-015306-us58wwmp 593 11 0 0 CD cord-015306-us58wwmp 593 12 - - SYM cord-015306-us58wwmp 593 13 18 18 CD cord-015306-us58wwmp 593 14 years year NNS cord-015306-us58wwmp 593 15 of of IN cord-015306-us58wwmp 593 16 age age NN cord-015306-us58wwmp 593 17 diagnosed diagnose VBN cord-015306-us58wwmp 593 18 with with IN cord-015306-us58wwmp 593 19 Tuberous Tuberous NNP cord-015306-us58wwmp 593 20 Sclerosis Sclerosis NNP cord-015306-us58wwmp 593 21 Complex Complex NNP cord-015306-us58wwmp 593 22 ( ( -LRB- cord-015306-us58wwmp 593 23 TSC TSC NNP cord-015306-us58wwmp 593 24 ) ) -RRB- cord-015306-us58wwmp 593 25 at at IN cord-015306-us58wwmp 593 26 a a DT cord-015306-us58wwmp 593 27 Tertiary Tertiary NNP cord-015306-us58wwmp 593 28 Hospital Hospital NNP cord-015306-us58wwmp 593 29 in in IN cord-015306-us58wwmp 593 30 South South NNP cord-015306-us58wwmp 593 31 India India NNP cord-015306-us58wwmp 593 32 . . . cord-015306-us58wwmp 594 1 Methods method NNS cord-015306-us58wwmp 594 2 : : : cord-015306-us58wwmp 594 3 Data datum NNS cord-015306-us58wwmp 594 4 of of IN cord-015306-us58wwmp 594 5 children child NNS cord-015306-us58wwmp 594 6 with with IN cord-015306-us58wwmp 594 7 TSC TSC NNP cord-015306-us58wwmp 594 8 who who WP cord-015306-us58wwmp 594 9 presented present VBD cord-015306-us58wwmp 594 10 to to IN cord-015306-us58wwmp 594 11 Christian Christian NNP cord-015306-us58wwmp 594 12 Medical Medical NNP cord-015306-us58wwmp 594 13 College College NNP cord-015306-us58wwmp 594 14 Vellore Vellore NNP cord-015306-us58wwmp 594 15 Hospital Hospital NNP cord-015306-us58wwmp 594 16 from from IN cord-015306-us58wwmp 594 17 January January NNP cord-015306-us58wwmp 594 18 2008 2008 CD cord-015306-us58wwmp 594 19 onwards onwards RB cord-015306-us58wwmp 594 20 , , , cord-015306-us58wwmp 594 21 were be VBD cord-015306-us58wwmp 594 22 analysed analyse VBN cord-015306-us58wwmp 594 23 by by IN cord-015306-us58wwmp 594 24 a a DT cord-015306-us58wwmp 594 25 retrospective retrospective JJ cord-015306-us58wwmp 594 26 chart chart NN cord-015306-us58wwmp 594 27 review review NN cord-015306-us58wwmp 594 28 . . . cord-015306-us58wwmp 595 1 The the DT cord-015306-us58wwmp 595 2 cases case NNS cord-015306-us58wwmp 595 3 were be VBD cord-015306-us58wwmp 595 4 identified identify VBN cord-015306-us58wwmp 595 5 from from IN cord-015306-us58wwmp 595 6 outpatient outpatient NN cord-015306-us58wwmp 595 7 records record NNS cord-015306-us58wwmp 595 8 and and CC cord-015306-us58wwmp 595 9 underwent undergo VBD cord-015306-us58wwmp 595 10 ultrasonography ultrasonography NN cord-015306-us58wwmp 595 11 , , , cord-015306-us58wwmp 595 12 urine urine NN cord-015306-us58wwmp 595 13 analysis analysis NN cord-015306-us58wwmp 595 14 and and CC cord-015306-us58wwmp 595 15 serum serum NN cord-015306-us58wwmp 595 16 creatinine creatinine NN cord-015306-us58wwmp 595 17 to to TO cord-015306-us58wwmp 595 18 recognize recognize VB cord-015306-us58wwmp 595 19 renal renal JJ cord-015306-us58wwmp 595 20 involvement involvement NN cord-015306-us58wwmp 595 21 . . . cord-015306-us58wwmp 596 1 Results result NNS cord-015306-us58wwmp 596 2 : : : cord-015306-us58wwmp 597 1 Twenty twenty CD cord-015306-us58wwmp 597 2 - - HYPH cord-015306-us58wwmp 597 3 five five CD cord-015306-us58wwmp 597 4 children child NNS cord-015306-us58wwmp 597 5 with with IN cord-015306-us58wwmp 597 6 TSC TSC NNP cord-015306-us58wwmp 597 7 were be VBD cord-015306-us58wwmp 597 8 identified identify VBN cord-015306-us58wwmp 597 9 . . . cord-015306-us58wwmp 598 1 Two two CD cord-015306-us58wwmp 598 2 children child NNS cord-015306-us58wwmp 598 3 did do VBD cord-015306-us58wwmp 598 4 not not RB cord-015306-us58wwmp 598 5 imaging image VBG cord-015306-us58wwmp 598 6 studies study NNS cord-015306-us58wwmp 598 7 available available JJ cord-015306-us58wwmp 598 8 and and CC cord-015306-us58wwmp 598 9 were be VBD cord-015306-us58wwmp 598 10 excluded exclude VBN cord-015306-us58wwmp 598 11 from from IN cord-015306-us58wwmp 598 12 the the DT cord-015306-us58wwmp 598 13 analysis analysis NN cord-015306-us58wwmp 598 14 . . . cord-015306-us58wwmp 599 1 The the DT cord-015306-us58wwmp 599 2 age age NN cord-015306-us58wwmp 599 3 of of IN cord-015306-us58wwmp 599 4 included include VBN cord-015306-us58wwmp 599 5 children child NNS cord-015306-us58wwmp 599 6 ranged range VBD cord-015306-us58wwmp 599 7 from from IN cord-015306-us58wwmp 599 8 5 5 CD cord-015306-us58wwmp 599 9 days day NNS cord-015306-us58wwmp 599 10 to to IN cord-015306-us58wwmp 599 11 15 15 CD cord-015306-us58wwmp 599 12 years year NNS cord-015306-us58wwmp 599 13 with with IN cord-015306-us58wwmp 599 14 a a DT cord-015306-us58wwmp 599 15 median median NN cord-015306-us58wwmp 599 16 of of IN cord-015306-us58wwmp 599 17 8 8 CD cord-015306-us58wwmp 599 18 years year NNS cord-015306-us58wwmp 599 19 . . . cord-015306-us58wwmp 600 1 Seventy seventy CD cord-015306-us58wwmp 600 2 four four CD cord-015306-us58wwmp 600 3 percent percent NN cord-015306-us58wwmp 600 4 ( ( -LRB- cord-015306-us58wwmp 600 5 17/23 17/23 CD cord-015306-us58wwmp 600 6 ) ) -RRB- cord-015306-us58wwmp 600 7 were be VBD cord-015306-us58wwmp 600 8 males male NNS cord-015306-us58wwmp 600 9 . . . cord-015306-us58wwmp 601 1 Ten ten CD cord-015306-us58wwmp 601 2 of of IN cord-015306-us58wwmp 601 3 the the DT cord-015306-us58wwmp 601 4 23 23 CD cord-015306-us58wwmp 601 5 children child NNS cord-015306-us58wwmp 601 6 had have VBD cord-015306-us58wwmp 601 7 evidence evidence NN cord-015306-us58wwmp 601 8 of of IN cord-015306-us58wwmp 601 9 renal renal JJ cord-015306-us58wwmp 601 10 involvement involvement NN cord-015306-us58wwmp 601 11 ( ( -LRB- cord-015306-us58wwmp 601 12 43.5 43.5 CD cord-015306-us58wwmp 601 13 % % NN cord-015306-us58wwmp 601 14 ) ) -RRB- cord-015306-us58wwmp 601 15 . . . cord-015306-us58wwmp 602 1 Of of IN cord-015306-us58wwmp 602 2 the the DT cord-015306-us58wwmp 602 3 ten ten CD cord-015306-us58wwmp 602 4 children child NNS cord-015306-us58wwmp 602 5 with with IN cord-015306-us58wwmp 602 6 renal renal JJ cord-015306-us58wwmp 602 7 involvement involvement NN cord-015306-us58wwmp 602 8 , , , cord-015306-us58wwmp 602 9 six six CD cord-015306-us58wwmp 602 10 had have VBD cord-015306-us58wwmp 602 11 angiomyolipoma angiomyolipoma NNS cord-015306-us58wwmp 602 12 ( ( -LRB- cord-015306-us58wwmp 602 13 60 60 CD cord-015306-us58wwmp 602 14 % % NN cord-015306-us58wwmp 602 15 ) ) -RRB- cord-015306-us58wwmp 602 16 , , , cord-015306-us58wwmp 602 17 five five CD cord-015306-us58wwmp 602 18 had have VBD cord-015306-us58wwmp 602 19 renal renal JJ cord-015306-us58wwmp 602 20 cysts cyst NNS cord-015306-us58wwmp 602 21 ( ( -LRB- cord-015306-us58wwmp 602 22 50 50 CD cord-015306-us58wwmp 602 23 % % NN cord-015306-us58wwmp 602 24 ) ) -RRB- cord-015306-us58wwmp 602 25 and and CC cord-015306-us58wwmp 602 26 one one PRP cord-015306-us58wwmp 602 27 had have VBD cord-015306-us58wwmp 602 28 suspected suspect VBN cord-015306-us58wwmp 602 29 renal renal JJ cord-015306-us58wwmp 602 30 cell cell NN cord-015306-us58wwmp 602 31 carcinoma carcinoma NN cord-015306-us58wwmp 602 32 . . . cord-015306-us58wwmp 603 1 In in IN cord-015306-us58wwmp 603 2 two two CD cord-015306-us58wwmp 603 3 children child NNS cord-015306-us58wwmp 603 4 both both CC cord-015306-us58wwmp 603 5 angiomyolipoma angiomyolipoma NNP cord-015306-us58wwmp 603 6 ( ( -LRB- cord-015306-us58wwmp 603 7 AML AML NNP cord-015306-us58wwmp 603 8 ) ) -RRB- cord-015306-us58wwmp 603 9 and and CC cord-015306-us58wwmp 603 10 cysts cyst NNS cord-015306-us58wwmp 603 11 were be VBD cord-015306-us58wwmp 603 12 noted note VBN cord-015306-us58wwmp 603 13 . . . cord-015306-us58wwmp 604 1 None none NN cord-015306-us58wwmp 604 2 were be VBD cord-015306-us58wwmp 604 3 symptomatic symptomatic JJ cord-015306-us58wwmp 604 4 . . . cord-015306-us58wwmp 605 1 One one CD cord-015306-us58wwmp 605 2 child child NN cord-015306-us58wwmp 605 3 was be VBD cord-015306-us58wwmp 605 4 found find VBN cord-015306-us58wwmp 605 5 to to TO cord-015306-us58wwmp 605 6 have have VB cord-015306-us58wwmp 605 7 proteinuria proteinuria NN cord-015306-us58wwmp 605 8 and and CC cord-015306-us58wwmp 605 9 another another DT cord-015306-us58wwmp 605 10 had have VBD cord-015306-us58wwmp 605 11 reduced reduce VBN cord-015306-us58wwmp 605 12 creatinine creatinine NN cord-015306-us58wwmp 605 13 clearance clearance NN cord-015306-us58wwmp 605 14 of of IN cord-015306-us58wwmp 605 15 52.5 52.5 CD cord-015306-us58wwmp 605 16 ml ml NNP cord-015306-us58wwmp 605 17 / / SYM cord-015306-us58wwmp 605 18 min min NNP cord-015306-us58wwmp 605 19 / / SYM cord-015306-us58wwmp 605 20 m m NNP cord-015306-us58wwmp 605 21 2 2 CD cord-015306-us58wwmp 605 22 with with IN cord-015306-us58wwmp 605 23 normal normal JJ cord-015306-us58wwmp 605 24 BP BP NNP cord-015306-us58wwmp 605 25 and and CC cord-015306-us58wwmp 605 26 urinalysis urinalysis NN cord-015306-us58wwmp 605 27 . . . cord-015306-us58wwmp 606 1 The the DT cord-015306-us58wwmp 606 2 rest rest NN cord-015306-us58wwmp 606 3 of of IN cord-015306-us58wwmp 606 4 children child NNS cord-015306-us58wwmp 606 5 had have VBD cord-015306-us58wwmp 606 6 no no DT cord-015306-us58wwmp 606 7 evidence evidence NN cord-015306-us58wwmp 606 8 of of IN cord-015306-us58wwmp 606 9 proteinuria proteinuria NN cord-015306-us58wwmp 606 10 and and CC cord-015306-us58wwmp 606 11 had have VBD cord-015306-us58wwmp 606 12 normal normal JJ cord-015306-us58wwmp 606 13 creatinine creatinine NN cord-015306-us58wwmp 606 14 clearance clearance NN cord-015306-us58wwmp 606 15 . . . cord-015306-us58wwmp 607 1 Conclusion conclusion NN cord-015306-us58wwmp 607 2 : : : cord-015306-us58wwmp 608 1 We -PRON- PRP cord-015306-us58wwmp 608 2 conclude conclude VBP cord-015306-us58wwmp 608 3 that that IN cord-015306-us58wwmp 608 4 all all DT cord-015306-us58wwmp 608 5 children child NNS cord-015306-us58wwmp 608 6 with with IN cord-015306-us58wwmp 608 7 TSC TSC NNP cord-015306-us58wwmp 608 8 should should MD cord-015306-us58wwmp 608 9 be be VB cord-015306-us58wwmp 608 10 screened screen VBN cord-015306-us58wwmp 608 11 for for IN cord-015306-us58wwmp 608 12 renal renal JJ cord-015306-us58wwmp 608 13 involvement involvement NN cord-015306-us58wwmp 608 14 and and CC cord-015306-us58wwmp 608 15 regular regular JJ cord-015306-us58wwmp 608 16 follow follow NN cord-015306-us58wwmp 608 17 up up RP cord-015306-us58wwmp 608 18 should should MD cord-015306-us58wwmp 608 19 be be VB cord-015306-us58wwmp 608 20 arranged arrange VBN cord-015306-us58wwmp 608 21 . . . cord-015306-us58wwmp 608 22 _SP cord-015306-us58wwmp 609 1 Abstract abstract JJ cord-015306-us58wwmp 609 2 # # NN cord-015306-us58wwmp 609 3 P p NN cord-015306-us58wwmp 609 4 - - HYPH cord-015306-us58wwmp 609 5 SAT069 sat069 NN cord-015306-us58wwmp 610 1 Sonographic sonographic JJ cord-015306-us58wwmp 610 2 growth growth NN cord-015306-us58wwmp 610 3 charts chart NNS cord-015306-us58wwmp 610 4 for for IN cord-015306-us58wwmp 610 5 kidney kidney NN cord-015306-us58wwmp 610 6 length length NN cord-015306-us58wwmp 610 7 in in IN cord-015306-us58wwmp 610 8 normal normal JJ cord-015306-us58wwmp 610 9 Korean korean JJ cord-015306-us58wwmp 610 10 children child NNS cord-015306-us58wwmp 610 11 : : : cord-015306-us58wwmp 610 12 a a DT cord-015306-us58wwmp 610 13 prospective prospective JJ cord-015306-us58wwmp 610 14 observational observational JJ cord-015306-us58wwmp 610 15 study study NN cord-015306-us58wwmp 610 16 Objective Objective NNP cord-015306-us58wwmp 610 17 and and CC cord-015306-us58wwmp 610 18 Methods Methods NNPS cord-015306-us58wwmp 611 1 : : : cord-015306-us58wwmp 611 2 Kidney kidney NN cord-015306-us58wwmp 611 3 length length NN cord-015306-us58wwmp 611 4 was be VBD cord-015306-us58wwmp 611 5 measured measure VBN cord-015306-us58wwmp 611 6 by by IN cord-015306-us58wwmp 611 7 sonography sonography VBG cord-015306-us58wwmp 611 8 in in IN cord-015306-us58wwmp 611 9 a a DT cord-015306-us58wwmp 611 10 prospective prospective JJ cord-015306-us58wwmp 611 11 observational observational JJ cord-015306-us58wwmp 611 12 study study NN cord-015306-us58wwmp 611 13 of of IN cord-015306-us58wwmp 611 14 343 343 CD cord-015306-us58wwmp 611 15 normal normal JJ cord-015306-us58wwmp 611 16 children child NNS cord-015306-us58wwmp 611 17 from from IN cord-015306-us58wwmp 611 18 0 0 CD cord-015306-us58wwmp 611 19 to to IN cord-015306-us58wwmp 611 20 12 12 CD cord-015306-us58wwmp 611 21 years year NNS cord-015306-us58wwmp 611 22 of of IN cord-015306-us58wwmp 611 23 age age NN cord-015306-us58wwmp 611 24 . . . cord-015306-us58wwmp 612 1 Results result NNS cord-015306-us58wwmp 612 2 and and CC cord-015306-us58wwmp 612 3 Conclusion conclusion NN cord-015306-us58wwmp 613 1 : : : cord-015306-us58wwmp 613 2 There there EX cord-015306-us58wwmp 613 3 was be VBD cord-015306-us58wwmp 613 4 a a DT cord-015306-us58wwmp 613 5 good good JJ cord-015306-us58wwmp 613 6 correlation correlation NN cord-015306-us58wwmp 613 7 between between IN cord-015306-us58wwmp 613 8 kidney kidney NN cord-015306-us58wwmp 613 9 length length NN cord-015306-us58wwmp 613 10 and and CC cord-015306-us58wwmp 613 11 somatic somatic JJ cord-015306-us58wwmp 613 12 values value NNS cord-015306-us58wwmp 613 13 including include VBG cord-015306-us58wwmp 613 14 age age NN cord-015306-us58wwmp 613 15 , , , cord-015306-us58wwmp 613 16 weight weight NN cord-015306-us58wwmp 613 17 , , , cord-015306-us58wwmp 613 18 and and CC cord-015306-us58wwmp 613 19 height height NN cord-015306-us58wwmp 613 20 . . . cord-015306-us58wwmp 614 1 The the DT cord-015306-us58wwmp 614 2 rapid rapid JJ cord-015306-us58wwmp 614 3 growth growth NN cord-015306-us58wwmp 614 4 of of IN cord-015306-us58wwmp 614 5 height height NN cord-015306-us58wwmp 614 6 during during IN cord-015306-us58wwmp 614 7 the the DT cord-015306-us58wwmp 614 8 first first JJ cord-015306-us58wwmp 614 9 2 2 CD cord-015306-us58wwmp 614 10 years year NNS cord-015306-us58wwmp 614 11 of of IN cord-015306-us58wwmp 614 12 life life NN cord-015306-us58wwmp 614 13 was be VBD cord-015306-us58wwmp 614 14 intimately intimately RB cord-015306-us58wwmp 614 15 associated associate VBN cord-015306-us58wwmp 614 16 with with IN cord-015306-us58wwmp 614 17 a a DT cord-015306-us58wwmp 614 18 similar similar JJ cord-015306-us58wwmp 614 19 increase increase NN cord-015306-us58wwmp 614 20 in in IN cord-015306-us58wwmp 614 21 kidney kidney NN cord-015306-us58wwmp 614 22 length length NN cord-015306-us58wwmp 614 23 . . . cord-015306-us58wwmp 615 1 The the DT cord-015306-us58wwmp 615 2 values value NNS cord-015306-us58wwmp 615 3 of of IN cord-015306-us58wwmp 615 4 weight weight NN cord-015306-us58wwmp 615 5 and and CC cord-015306-us58wwmp 615 6 height height NN cord-015306-us58wwmp 615 7 showed show VBD cord-015306-us58wwmp 615 8 good good JJ cord-015306-us58wwmp 615 9 correlation correlation NN cord-015306-us58wwmp 615 10 with with IN cord-015306-us58wwmp 615 11 kidney kidney NN cord-015306-us58wwmp 615 12 length length NN cord-015306-us58wwmp 615 13 in in IN cord-015306-us58wwmp 615 14 children child NNS cord-015306-us58wwmp 615 15 from from IN cord-015306-us58wwmp 615 16 2 2 CD cord-015306-us58wwmp 615 17 to to TO cord-015306-us58wwmp 615 18 12 12 CD cord-015306-us58wwmp 615 19 years year NNS cord-015306-us58wwmp 615 20 of of IN cord-015306-us58wwmp 615 21 age age NN cord-015306-us58wwmp 615 22 . . . cord-015306-us58wwmp 616 1 Height Height NNP cord-015306-us58wwmp 616 2 should should MD cord-015306-us58wwmp 616 3 be be VB cord-015306-us58wwmp 616 4 considered consider VBN cord-015306-us58wwmp 616 5 the the DT cord-015306-us58wwmp 616 6 important important JJ cord-015306-us58wwmp 616 7 factor factor NN cord-015306-us58wwmp 616 8 to to TO cord-015306-us58wwmp 616 9 correlate correlate VB cord-015306-us58wwmp 616 10 with with IN cord-015306-us58wwmp 616 11 kidney kidney NN cord-015306-us58wwmp 616 12 length length NN cord-015306-us58wwmp 616 13 . . . cord-015306-us58wwmp 617 1 For for IN cord-015306-us58wwmp 617 2 the the DT cord-015306-us58wwmp 617 3 children child NNS cord-015306-us58wwmp 617 4 aged age VBN cord-015306-us58wwmp 617 5 2 2 CD cord-015306-us58wwmp 617 6 years year NNS cord-015306-us58wwmp 617 7 or or CC cord-015306-us58wwmp 617 8 older old JJR cord-015306-us58wwmp 617 9 , , , cord-015306-us58wwmp 617 10 the the DT cord-015306-us58wwmp 617 11 regression regression NN cord-015306-us58wwmp 617 12 equation equation NN cord-015306-us58wwmp 617 13 was be VBD cord-015306-us58wwmp 617 14 obtained obtain VBN cord-015306-us58wwmp 617 15 : : : cord-015306-us58wwmp 617 16 kidney kidney NN cord-015306-us58wwmp 617 17 length length NN cord-015306-us58wwmp 617 18 ( ( -LRB- cord-015306-us58wwmp 617 19 cm cm NNP cord-015306-us58wwmp 617 20 ) ) -RRB- cord-015306-us58wwmp 617 21 = = NFP cord-015306-us58wwmp 618 1 2.677 2.677 CD cord-015306-us58wwmp 618 2 + + CC cord-015306-us58wwmp 619 1 0.046 0.046 CD cord-015306-us58wwmp 619 2 x x SYM cord-015306-us58wwmp 619 3 height height NN cord-015306-us58wwmp 619 4 ( ( -LRB- cord-015306-us58wwmp 619 5 cm cm NNP cord-015306-us58wwmp 619 6 ) ) -RRB- cord-015306-us58wwmp 619 7 . . . cord-015306-us58wwmp 620 1 For for IN cord-015306-us58wwmp 620 2 the the DT cord-015306-us58wwmp 620 3 younger young JJR cord-015306-us58wwmp 620 4 than than IN cord-015306-us58wwmp 620 5 2 2 CD cord-015306-us58wwmp 620 6 years year NNS cord-015306-us58wwmp 620 7 , , , cord-015306-us58wwmp 620 8 the the DT cord-015306-us58wwmp 620 9 equation equation NN cord-015306-us58wwmp 620 10 was be VBD cord-015306-us58wwmp 620 11 : : : cord-015306-us58wwmp 620 12 kidney kidney NN cord-015306-us58wwmp 620 13 length length NN cord-015306-us58wwmp 620 14 ( ( -LRB- cord-015306-us58wwmp 620 15 cm cm NNP cord-015306-us58wwmp 620 16 ) ) -RRB- cord-015306-us58wwmp 620 17 = = NFP cord-015306-us58wwmp 621 1 1.120 1.120 CD cord-015306-us58wwmp 621 2 + + CC cord-015306-us58wwmp 622 1 0.066 0.066 CD cord-015306-us58wwmp 622 2 x x SYM cord-015306-us58wwmp 622 3 height height NN cord-015306-us58wwmp 622 4 ( ( -LRB- cord-015306-us58wwmp 622 5 cm cm NNP cord-015306-us58wwmp 622 6 ) ) -RRB- cord-015306-us58wwmp 622 7 . . . cord-015306-us58wwmp 623 1 Objective objective NN cord-015306-us58wwmp 623 2 : : : cord-015306-us58wwmp 624 1 The the DT cord-015306-us58wwmp 624 2 outcome outcome NN cord-015306-us58wwmp 624 3 of of IN cord-015306-us58wwmp 624 4 children child NNS cord-015306-us58wwmp 624 5 with with IN cord-015306-us58wwmp 624 6 unilateral unilateral JJ cord-015306-us58wwmp 624 7 nonfunctioning nonfunctioning JJ cord-015306-us58wwmp 624 8 MCDK MCDK NNP cord-015306-us58wwmp 624 9 . . . cord-015306-us58wwmp 625 1 Methods method NNS cord-015306-us58wwmp 625 2 : : : cord-015306-us58wwmp 625 3 24 24 CD cord-015306-us58wwmp 625 4 children child NNS cord-015306-us58wwmp 625 5 ( ( -LRB- cord-015306-us58wwmp 625 6 13 13 CD cord-015306-us58wwmp 625 7 pts pt NNS cord-015306-us58wwmp 625 8 with with IN cord-015306-us58wwmp 625 9 right right JJ cord-015306-us58wwmp 625 10 MCDK MCDK NNP cord-015306-us58wwmp 625 11 ) ) -RRB- cord-015306-us58wwmp 625 12 , , , cord-015306-us58wwmp 625 13 afunction afunction NN cord-015306-us58wwmp 625 14 confirmed confirm VBN cord-015306-us58wwmp 625 15 by by IN cord-015306-us58wwmp 625 16 renal renal JJ cord-015306-us58wwmp 625 17 scan scan NN cord-015306-us58wwmp 625 18 , , , cord-015306-us58wwmp 625 19 12 12 CD cord-015306-us58wwmp 625 20 boys boy NNS cord-015306-us58wwmp 625 21 , , , cord-015306-us58wwmp 625 22 mean mean VB cord-015306-us58wwmp 625 23 age age NN cord-015306-us58wwmp 625 24 of of IN cord-015306-us58wwmp 625 25 6 6 CD cord-015306-us58wwmp 625 26 years year NNS cord-015306-us58wwmp 625 27 ( ( -LRB- cord-015306-us58wwmp 625 28 range range VBP cord-015306-us58wwmp 625 29 1.5 1.5 CD cord-015306-us58wwmp 625 30 month month NN cord-015306-us58wwmp 625 31 -21.5 -21.5 NNP cord-015306-us58wwmp 625 32 years year NNS cord-015306-us58wwmp 625 33 ) ) -RRB- cord-015306-us58wwmp 625 34 , , , cord-015306-us58wwmp 625 35 mean mean JJ cord-015306-us58wwmp 625 36 observation observation NN cord-015306-us58wwmp 625 37 period period NN cord-015306-us58wwmp 625 38 of of IN cord-015306-us58wwmp 625 39 6.7 6.7 CD cord-015306-us58wwmp 625 40 years year NNS cord-015306-us58wwmp 625 41 with with IN cord-015306-us58wwmp 625 42 a a DT cord-015306-us58wwmp 625 43 range range NN cord-015306-us58wwmp 625 44 of of IN cord-015306-us58wwmp 625 45 1.5 1.5 CD cord-015306-us58wwmp 625 46 month month NN cord-015306-us58wwmp 625 47 -21.5 -21.5 NNP cord-015306-us58wwmp 625 48 years year NNS cord-015306-us58wwmp 625 49 . . . cord-015306-us58wwmp 626 1 Prenatally Prenatally NNP cord-015306-us58wwmp 626 2 diagnosis diagnosis NN cord-015306-us58wwmp 626 3 was be VBD cord-015306-us58wwmp 626 4 made make VBN cord-015306-us58wwmp 626 5 in in IN cord-015306-us58wwmp 626 6 83 83 CD cord-015306-us58wwmp 626 7 % % NN cord-015306-us58wwmp 626 8 . . . cord-015306-us58wwmp 627 1 Abnormalities abnormality NNS cord-015306-us58wwmp 627 2 of of IN cord-015306-us58wwmp 627 3 the the DT cord-015306-us58wwmp 627 4 contralateral contralateral JJ cord-015306-us58wwmp 627 5 kidney kidney NN cord-015306-us58wwmp 627 6 were be VBD cord-015306-us58wwmp 627 7 found find VBN cord-015306-us58wwmp 627 8 in in IN cord-015306-us58wwmp 627 9 4 4 CD cord-015306-us58wwmp 627 10 /24 /24 NNP cord-015306-us58wwmp 627 11 pts pts NNP cord-015306-us58wwmp 627 12 ( ( -LRB- cord-015306-us58wwmp 627 13 13 13 CD cord-015306-us58wwmp 627 14 % % NN cord-015306-us58wwmp 627 15 ) ) -RRB- cord-015306-us58wwmp 628 1 -dystopia -dystopia RB cord-015306-us58wwmp 629 1 ( ( -LRB- cord-015306-us58wwmp 629 2 n=2 n=2 NNS cord-015306-us58wwmp 629 3 ) ) -RRB- cord-015306-us58wwmp 629 4 , , , cord-015306-us58wwmp 629 5 hydronephrosis hydronephrosis NN cord-015306-us58wwmp 629 6 due due IN cord-015306-us58wwmp 629 7 to to IN cord-015306-us58wwmp 629 8 ureterovesical ureterovesical JJ cord-015306-us58wwmp 629 9 obstruction obstruction NN cord-015306-us58wwmp 629 10 ( ( -LRB- cord-015306-us58wwmp 629 11 n=1 n=1 CD cord-015306-us58wwmp 629 12 ) ) -RRB- cord-015306-us58wwmp 629 13 , , , cord-015306-us58wwmp 629 14 VACTER VACTER NNP cord-015306-us58wwmp 629 15 syndrome syndrome NN cord-015306-us58wwmp 629 16 ( ( -LRB- cord-015306-us58wwmp 629 17 n=1 n=1 CD cord-015306-us58wwmp 629 18 ) ) -RRB- cord-015306-us58wwmp 629 19 . . . cord-015306-us58wwmp 630 1 In in IN cord-015306-us58wwmp 630 2 2 2 CD cord-015306-us58wwmp 630 3 pts pts CD cord-015306-us58wwmp 630 4 MCDK MCDK NNP cord-015306-us58wwmp 630 5 had have VBD cord-015306-us58wwmp 630 6 been be VBN cord-015306-us58wwmp 630 7 removed remove VBN cord-015306-us58wwmp 630 8 ( ( -LRB- cord-015306-us58wwmp 630 9 in in IN cord-015306-us58wwmp 630 10 period period NN cord-015306-us58wwmp 630 11 1991 1991 CD cord-015306-us58wwmp 630 12 - - SYM cord-015306-us58wwmp 630 13 1997 1997 CD cord-015306-us58wwmp 630 14 ) ) -RRB- cord-015306-us58wwmp 630 15 . . . cord-015306-us58wwmp 631 1 Collected collect VBN cord-015306-us58wwmp 631 2 data datum NNS cord-015306-us58wwmp 631 3 include include VBP cord-015306-us58wwmp 631 4 eGFR egfr JJ cord-015306-us58wwmp 631 5 ( ( -LRB- cord-015306-us58wwmp 631 6 calculated calculate VBN cord-015306-us58wwmp 631 7 by by IN cord-015306-us58wwmp 631 8 Cystatin Cystatin NNP cord-015306-us58wwmp 631 9 C C NNP cord-015306-us58wwmp 631 10 ) ) -RRB- cord-015306-us58wwmp 631 11 , , , cord-015306-us58wwmp 631 12 urine urine NN cord-015306-us58wwmp 631 13 protein protein NN cord-015306-us58wwmp 631 14 / / SYM cord-015306-us58wwmp 631 15 creatinine creatinine NN cord-015306-us58wwmp 631 16 ratio ratio NN cord-015306-us58wwmp 631 17 , , , cord-015306-us58wwmp 631 18 microalbumin microalbumin NNP cord-015306-us58wwmp 631 19 / / SYM cord-015306-us58wwmp 631 20 creatinine creatinine NN cord-015306-us58wwmp 631 21 ratio ratio NN cord-015306-us58wwmp 631 22 , , , cord-015306-us58wwmp 631 23 A1microglobulin a1microglobulin FW cord-015306-us58wwmp 631 24 ( ( -LRB- cord-015306-us58wwmp 631 25 A1M)/creatinine a1m)/creatinine JJ cord-015306-us58wwmp 631 26 ratio ratio NN cord-015306-us58wwmp 631 27 , , , cord-015306-us58wwmp 631 28 urine urine NN cord-015306-us58wwmp 631 29 Beta-2microglobulin beta-2microglobulin NN cord-015306-us58wwmp 631 30 ( ( -LRB- cord-015306-us58wwmp 631 31 B2 b2 NN cord-015306-us58wwmp 631 32 M M NNP cord-015306-us58wwmp 631 33 ) ) -RRB- cord-015306-us58wwmp 631 34 , , , cord-015306-us58wwmp 631 35 urine urine NN cord-015306-us58wwmp 631 36 NGAL NGAL NNP cord-015306-us58wwmp 631 37 , , , cord-015306-us58wwmp 631 38 urine urine NN cord-015306-us58wwmp 631 39 NAG nag NN cord-015306-us58wwmp 631 40 , , , cord-015306-us58wwmp 631 41 blood blood NN cord-015306-us58wwmp 631 42 pressure pressure NN cord-015306-us58wwmp 631 43 ( ( -LRB- cord-015306-us58wwmp 631 44 BP BP NNP cord-015306-us58wwmp 631 45 ) ) -RRB- cord-015306-us58wwmp 631 46 , , , cord-015306-us58wwmp 631 47 renal renal JJ cord-015306-us58wwmp 631 48 length length NN cord-015306-us58wwmp 631 49 . . . cord-015306-us58wwmp 632 1 Results result NNS cord-015306-us58wwmp 632 2 : : : cord-015306-us58wwmp 633 1 Hypetrophy Hypetrophy NNP cord-015306-us58wwmp 633 2 of of IN cord-015306-us58wwmp 633 3 the the DT cord-015306-us58wwmp 633 4 contralateral contralateral JJ cord-015306-us58wwmp 633 5 kidney kidney NN cord-015306-us58wwmp 633 6 ( ( -LRB- cord-015306-us58wwmp 633 7 length length NN cord-015306-us58wwmp 633 8 > > XX cord-015306-us58wwmp 633 9 2 2 CD cord-015306-us58wwmp 633 10 SDS SDS NNP cord-015306-us58wwmp 633 11 ) ) -RRB- cord-015306-us58wwmp 633 12 was be VBD cord-015306-us58wwmp 633 13 detected detect VBN cord-015306-us58wwmp 633 14 in in IN cord-015306-us58wwmp 633 15 19/24 19/24 CD cord-015306-us58wwmp 633 16 pts pt NNS cord-015306-us58wwmp 633 17 ( ( -LRB- cord-015306-us58wwmp 633 18 79 79 CD cord-015306-us58wwmp 633 19 % % NN cord-015306-us58wwmp 633 20 ) ) -RRB- cord-015306-us58wwmp 633 21 to to IN cord-015306-us58wwmp 633 22 2 2 CD cord-015306-us58wwmp 633 23 years year NNS cord-015306-us58wwmp 633 24 of of IN cord-015306-us58wwmp 633 25 age age NN cord-015306-us58wwmp 633 26 . . . cord-015306-us58wwmp 634 1 Complete complete JJ cord-015306-us58wwmp 634 2 involution involution NN cord-015306-us58wwmp 634 3 ( ( -LRB- cord-015306-us58wwmp 634 4 in in IN cord-015306-us58wwmp 634 5 33 33 CD cord-015306-us58wwmp 634 6 % % NN cord-015306-us58wwmp 634 7 ) ) -RRB- cord-015306-us58wwmp 634 8 or or CC cord-015306-us58wwmp 634 9 decrease decrease NN cord-015306-us58wwmp 634 10 of of IN cord-015306-us58wwmp 634 11 size size NN cord-015306-us58wwmp 634 12 ( ( -LRB- cord-015306-us58wwmp 634 13 in in IN cord-015306-us58wwmp 634 14 30 30 CD cord-015306-us58wwmp 634 15 % % NN cord-015306-us58wwmp 634 16 ) ) -RRB- cord-015306-us58wwmp 634 17 of of IN cord-015306-us58wwmp 634 18 MCDK MCDK NNP cord-015306-us58wwmp 634 19 occured occur VBD cord-015306-us58wwmp 634 20 in in IN cord-015306-us58wwmp 634 21 the the DT cord-015306-us58wwmp 634 22 first first JJ cord-015306-us58wwmp 634 23 5 5 CD cord-015306-us58wwmp 634 24 years year NNS cord-015306-us58wwmp 634 25 . . . cord-015306-us58wwmp 635 1 Hyperfiltration hyperfiltration NN cord-015306-us58wwmp 635 2 ( ( -LRB- cord-015306-us58wwmp 635 3 defined define VBN cord-015306-us58wwmp 635 4 as as IN cord-015306-us58wwmp 635 5 eGFR egfr NN cord-015306-us58wwmp 635 6 of of IN cord-015306-us58wwmp 635 7 149 149 CD cord-015306-us58wwmp 635 8 ml ml NN cord-015306-us58wwmp 635 9 / / SYM cord-015306-us58wwmp 635 10 min/1.73m2 min/1.73m2 NNP cord-015306-us58wwmp 635 11 ) ) -RRB- cord-015306-us58wwmp 635 12 was be VBD cord-015306-us58wwmp 635 13 seen see VBN cord-015306-us58wwmp 635 14 in in IN cord-015306-us58wwmp 635 15 4 4 CD cord-015306-us58wwmp 635 16 pts pt NNS cord-015306-us58wwmp 635 17 ( ( -LRB- cord-015306-us58wwmp 635 18 17 17 CD cord-015306-us58wwmp 635 19 % % NN cord-015306-us58wwmp 635 20 ) ) -RRB- cord-015306-us58wwmp 635 21 . . . cord-015306-us58wwmp 636 1 None none NN cord-015306-us58wwmp 636 2 of of IN cord-015306-us58wwmp 636 3 24 24 CD cord-015306-us58wwmp 636 4 pts pt NNS cord-015306-us58wwmp 636 5 demonstrated demonstrate VBN cord-015306-us58wwmp 636 6 decreased decrease VBN cord-015306-us58wwmp 636 7 eGFR egfr NN cord-015306-us58wwmp 636 8 , , , cord-015306-us58wwmp 636 9 proteinuria proteinuria NN cord-015306-us58wwmp 636 10 ( ( -LRB- cord-015306-us58wwmp 636 11 mean mean JJ cord-015306-us58wwmp 636 12 value value NN cord-015306-us58wwmp 636 13 of of IN cord-015306-us58wwmp 636 14 24.8 24.8 CD cord-015306-us58wwmp 636 15 mg mg NNP cord-015306-us58wwmp 636 16 / / SYM cord-015306-us58wwmp 636 17 mmolcreatinine mmolcreatinine NNP cord-015306-us58wwmp 636 18 ) ) -RRB- cord-015306-us58wwmp 636 19 , , . cord-015306-us58wwmp 637 1 microalbuminuria microalbuminuria NNP cord-015306-us58wwmp 637 2 ( ( -LRB- cord-015306-us58wwmp 637 3 mean mean JJ cord-015306-us58wwmp 637 4 value value NN cord-015306-us58wwmp 637 5 of of IN cord-015306-us58wwmp 637 6 2.0 2.0 CD cord-015306-us58wwmp 637 7 mg mg NNP cord-015306-us58wwmp 637 8 / / SYM cord-015306-us58wwmp 637 9 mmolcreatinine).Urine mmolcreatinine).Urine NNP cord-015306-us58wwmp 637 10 A1 A1 NNP cord-015306-us58wwmp 637 11 M M NNP cord-015306-us58wwmp 637 12 ( ( -LRB- cord-015306-us58wwmp 637 13 mean mean JJ cord-015306-us58wwmp 637 14 value value NN cord-015306-us58wwmp 637 15 of of IN cord-015306-us58wwmp 637 16 5.8 5.8 CD cord-015306-us58wwmp 637 17 mg mg NNP cord-015306-us58wwmp 637 18 / / SYM cord-015306-us58wwmp 637 19 mmolcreatinine mmolcreatinine NNP cord-015306-us58wwmp 637 20 ) ) -RRB- cord-015306-us58wwmp 637 21 , , , cord-015306-us58wwmp 637 22 urine urine NN cord-015306-us58wwmp 637 23 B2 b2 NN cord-015306-us58wwmp 637 24 M M NNP cord-015306-us58wwmp 638 1 ( ( -LRB- cord-015306-us58wwmp 638 2 mean mean JJ cord-015306-us58wwmp 638 3 value value NN cord-015306-us58wwmp 638 4 of of IN cord-015306-us58wwmp 638 5 0.2 0.2 CD cord-015306-us58wwmp 638 6 mg mg NNP cord-015306-us58wwmp 638 7 / / SYM cord-015306-us58wwmp 638 8 l l NNP cord-015306-us58wwmp 638 9 ) ) -RRB- cord-015306-us58wwmp 638 10 , , , cord-015306-us58wwmp 638 11 urine urine NN cord-015306-us58wwmp 638 12 NAG NAG NNP cord-015306-us58wwmp 638 13 ( ( -LRB- cord-015306-us58wwmp 638 14 mean mean VB cord-015306-us58wwmp 638 15 value value NN cord-015306-us58wwmp 638 16 of of IN cord-015306-us58wwmp 638 17 7.3 7.3 CD cord-015306-us58wwmp 638 18 Ukat Ukat NNP cord-015306-us58wwmp 638 19 / / SYM cord-015306-us58wwmp 638 20 mmolcreatinine mmolcreatinine NNP cord-015306-us58wwmp 638 21 ) ) -RRB- cord-015306-us58wwmp 638 22 , , , cord-015306-us58wwmp 638 23 urine urine NN cord-015306-us58wwmp 638 24 NGAL NGAL NNP cord-015306-us58wwmp 639 1 ( ( -LRB- cord-015306-us58wwmp 639 2 mean mean JJ cord-015306-us58wwmp 639 3 value value NN cord-015306-us58wwmp 639 4 of of IN cord-015306-us58wwmp 639 5 10.4 10.4 CD cord-015306-us58wwmp 639 6 ng ng NN cord-015306-us58wwmp 639 7 / / SYM cord-015306-us58wwmp 639 8 l l NN cord-015306-us58wwmp 639 9 ) ) -RRB- cord-015306-us58wwmp 639 10 were be VBD cord-015306-us58wwmp 639 11 in in IN cord-015306-us58wwmp 639 12 a a DT cord-015306-us58wwmp 639 13 normal normal JJ cord-015306-us58wwmp 639 14 range range NN cord-015306-us58wwmp 639 15 . . . cord-015306-us58wwmp 640 1 All all DT cord-015306-us58wwmp 640 2 pts pt NNS cord-015306-us58wwmp 640 3 were be VBD cord-015306-us58wwmp 640 4 normotensive normotensive JJ cord-015306-us58wwmp 640 5 -BP -BP NNP cord-015306-us58wwmp 641 1 defined define VBN cord-015306-us58wwmp 641 2 as as IN cord-015306-us58wwmp 641 3 < < NNP cord-015306-us58wwmp 641 4 95th 95th NNP cord-015306-us58wwmp 641 5 percentile percentile NN cord-015306-us58wwmp 641 6 for for IN cord-015306-us58wwmp 641 7 age age NN cord-015306-us58wwmp 641 8 and and CC cord-015306-us58wwmp 641 9 gender gender NN cord-015306-us58wwmp 641 10 . . . cord-015306-us58wwmp 642 1 The the DT cord-015306-us58wwmp 642 2 combination combination NN cord-015306-us58wwmp 642 3 of of IN cord-015306-us58wwmp 642 4 hepatoblastoma hepatoblastoma NN cord-015306-us58wwmp 642 5 with with IN cord-015306-us58wwmp 642 6 renal renal JJ cord-015306-us58wwmp 642 7 failure failure NN cord-015306-us58wwmp 642 8 due due IN cord-015306-us58wwmp 642 9 to to IN cord-015306-us58wwmp 642 10 congenital congenital JJ cord-015306-us58wwmp 642 11 dysplastic dysplastic JJ cord-015306-us58wwmp 642 12 kidneys kidney NNS cord-015306-us58wwmp 642 13 in in IN cord-015306-us58wwmp 642 14 children child NNS cord-015306-us58wwmp 642 15 is be VBZ cord-015306-us58wwmp 642 16 extremely extremely RB cord-015306-us58wwmp 642 17 rare rare JJ cord-015306-us58wwmp 642 18 . . . cord-015306-us58wwmp 643 1 We -PRON- PRP cord-015306-us58wwmp 643 2 report report VBP cord-015306-us58wwmp 643 3 two two CD cord-015306-us58wwmp 643 4 children child NNS cord-015306-us58wwmp 643 5 in in IN cord-015306-us58wwmp 643 6 renal renal JJ cord-015306-us58wwmp 643 7 failure failure NN cord-015306-us58wwmp 643 8 since since IN cord-015306-us58wwmp 643 9 birth birth NN cord-015306-us58wwmp 643 10 due due IN cord-015306-us58wwmp 643 11 to to IN cord-015306-us58wwmp 643 12 congenital congenital JJ cord-015306-us58wwmp 643 13 cystic cystic JJ cord-015306-us58wwmp 643 14 dysplastic dysplastic JJ cord-015306-us58wwmp 643 15 kidneys kidney NNS cord-015306-us58wwmp 643 16 . . . cord-015306-us58wwmp 644 1 Hepatoblastoma Hepatoblastoma NNP cord-015306-us58wwmp 644 2 was be VBD cord-015306-us58wwmp 644 3 subsequently subsequently RB cord-015306-us58wwmp 644 4 diagnosed diagnose VBN cord-015306-us58wwmp 644 5 in in IN cord-015306-us58wwmp 644 6 both both DT cord-015306-us58wwmp 644 7 of of IN cord-015306-us58wwmp 644 8 them -PRON- PRP cord-015306-us58wwmp 644 9 . . . cord-015306-us58wwmp 645 1 Methods method NNS cord-015306-us58wwmp 645 2 and and CC cord-015306-us58wwmp 645 3 Results result NNS cord-015306-us58wwmp 645 4 : : : cord-015306-us58wwmp 646 1 Case1 Case1 NNP cord-015306-us58wwmp 647 1 A a DT cord-015306-us58wwmp 647 2 male male JJ cord-015306-us58wwmp 647 3 infant infant NN cord-015306-us58wwmp 647 4 was be VBD cord-015306-us58wwmp 647 5 born bear VBN cord-015306-us58wwmp 647 6 at at IN cord-015306-us58wwmp 647 7 35 35 CD cord-015306-us58wwmp 647 8 weeks week NNS cord-015306-us58wwmp 647 9 gestation gestation NN cord-015306-us58wwmp 647 10 with with IN cord-015306-us58wwmp 647 11 an an DT cord-015306-us58wwmp 647 12 antenatal antenatal JJ cord-015306-us58wwmp 647 13 diagnosis diagnosis NN cord-015306-us58wwmp 647 14 of of IN cord-015306-us58wwmp 647 15 bilateral bilateral JJ cord-015306-us58wwmp 647 16 dysplastic dysplastic JJ cord-015306-us58wwmp 647 17 kidneys kidney NNS cord-015306-us58wwmp 647 18 and and CC cord-015306-us58wwmp 647 19 bladder bladder NN cord-015306-us58wwmp 647 20 outflow outflow NN cord-015306-us58wwmp 647 21 obstruction obstruction NN cord-015306-us58wwmp 647 22 secondary secondary JJ cord-015306-us58wwmp 647 23 to to IN cord-015306-us58wwmp 647 24 a a DT cord-015306-us58wwmp 647 25 prolapsing prolapse VBG cord-015306-us58wwmp 647 26 ureterocele ureterocele NNP cord-015306-us58wwmp 647 27 , , , cord-015306-us58wwmp 647 28 anhydramnios anhydramnio NNS cord-015306-us58wwmp 647 29 , , , cord-015306-us58wwmp 647 30 and and CC cord-015306-us58wwmp 647 31 pulmonary pulmonary JJ cord-015306-us58wwmp 647 32 hypoplasia hypoplasia NN cord-015306-us58wwmp 647 33 . . . cord-015306-us58wwmp 648 1 He -PRON- PRP cord-015306-us58wwmp 648 2 underwent undergo VBD cord-015306-us58wwmp 648 3 surgical surgical JJ cord-015306-us58wwmp 648 4 repair repair NN cord-015306-us58wwmp 648 5 of of IN cord-015306-us58wwmp 648 6 other other JJ cord-015306-us58wwmp 648 7 congeniatal congeniatal JJ cord-015306-us58wwmp 648 8 abnormality abnormality NN cord-015306-us58wwmp 648 9 after after IN cord-015306-us58wwmp 648 10 birth birth NN cord-015306-us58wwmp 648 11 . . . cord-015306-us58wwmp 649 1 Peritoneal peritoneal JJ cord-015306-us58wwmp 649 2 dialysis dialysis NN cord-015306-us58wwmp 649 3 was be VBD cord-015306-us58wwmp 649 4 initiated initiate VBN cord-015306-us58wwmp 649 5 at at IN cord-015306-us58wwmp 649 6 3 3 CD cord-015306-us58wwmp 649 7 months month NNS cord-015306-us58wwmp 649 8 . . . cord-015306-us58wwmp 650 1 Treatment treatment NN cord-015306-us58wwmp 650 2 with with IN cord-015306-us58wwmp 650 3 Erythropoietin Erythropoietin NNP cord-015306-us58wwmp 650 4 ( ( -LRB- cord-015306-us58wwmp 650 5 EPO EPO NNP cord-015306-us58wwmp 650 6 ) ) -RRB- cord-015306-us58wwmp 650 7 was be VBD cord-015306-us58wwmp 650 8 commenced commence VBN cord-015306-us58wwmp 650 9 at at IN cord-015306-us58wwmp 650 10 6 6 CD cord-015306-us58wwmp 650 11 weeks week NNS cord-015306-us58wwmp 650 12 of of IN cord-015306-us58wwmp 650 13 age age NN cord-015306-us58wwmp 650 14 . . . cord-015306-us58wwmp 651 1 Case case NN cord-015306-us58wwmp 651 2 2 2 CD cord-015306-us58wwmp 652 1 A a DT cord-015306-us58wwmp 652 2 male male JJ cord-015306-us58wwmp 652 3 infant infant NN cord-015306-us58wwmp 652 4 with with IN cord-015306-us58wwmp 652 5 congenital congenital JJ cord-015306-us58wwmp 652 6 cystic cystic JJ cord-015306-us58wwmp 652 7 renal renal JJ cord-015306-us58wwmp 652 8 dysplasia dysplasia NN cord-015306-us58wwmp 652 9 , , , cord-015306-us58wwmp 652 10 bilateral bilateral JJ cord-015306-us58wwmp 652 11 vesicoureteric vesicoureteric JJ cord-015306-us58wwmp 652 12 reflux reflux NN cord-015306-us58wwmp 652 13 pulmonary pulmonary JJ cord-015306-us58wwmp 652 14 hypoplasia hypoplasia NN cord-015306-us58wwmp 652 15 and and CC cord-015306-us58wwmp 652 16 oligohydramnios oligohydramnios NNP cord-015306-us58wwmp 652 17 was be VBD cord-015306-us58wwmp 652 18 born bear VBN cord-015306-us58wwmp 652 19 at at IN cord-015306-us58wwmp 652 20 36 36 CD cord-015306-us58wwmp 652 21 weeks week NNS cord-015306-us58wwmp 652 22 gestation gestation NN cord-015306-us58wwmp 652 23 . . . cord-015306-us58wwmp 653 1 Peritoneal peritoneal JJ cord-015306-us58wwmp 653 2 dialysis dialysis NN cord-015306-us58wwmp 653 3 was be VBD cord-015306-us58wwmp 653 4 commenced commence VBN cord-015306-us58wwmp 653 5 at at IN cord-015306-us58wwmp 653 6 day day NN cord-015306-us58wwmp 653 7 20 20 CD cord-015306-us58wwmp 653 8 due due IN cord-015306-us58wwmp 653 9 to to IN cord-015306-us58wwmp 653 10 anuria anuria NN cord-015306-us58wwmp 653 11 from from IN cord-015306-us58wwmp 653 12 birth birth NN cord-015306-us58wwmp 653 13 . . . cord-015306-us58wwmp 654 1 EPO EPO NNP cord-015306-us58wwmp 654 2 was be VBD cord-015306-us58wwmp 654 3 commenced commence VBN cord-015306-us58wwmp 654 4 at at IN cord-015306-us58wwmp 654 5 6 6 CD cord-015306-us58wwmp 654 6 months month NNS cord-015306-us58wwmp 654 7 of of IN cord-015306-us58wwmp 654 8 age age NN cord-015306-us58wwmp 654 9 . . . cord-015306-us58wwmp 655 1 Both both DT cord-015306-us58wwmp 655 2 of of IN cord-015306-us58wwmp 655 3 them -PRON- PRP cord-015306-us58wwmp 655 4 required require VBD cord-015306-us58wwmp 655 5 high high JJ cord-015306-us58wwmp 655 6 dose dose NN cord-015306-us58wwmp 655 7 EPO EPO NNP cord-015306-us58wwmp 655 8 to to TO cord-015306-us58wwmp 655 9 maintain maintain VB cord-015306-us58wwmp 655 10 adequate adequate JJ cord-015306-us58wwmp 655 11 haemoglobin haemoglobin NN cord-015306-us58wwmp 655 12 . . . cord-015306-us58wwmp 656 1 Hepatoblastoma Hepatoblastoma NNP cord-015306-us58wwmp 656 2 was be VBD cord-015306-us58wwmp 656 3 diagnosed diagnose VBN cord-015306-us58wwmp 656 4 in in IN cord-015306-us58wwmp 656 5 both both DT cord-015306-us58wwmp 656 6 of of IN cord-015306-us58wwmp 656 7 them -PRON- PRP cord-015306-us58wwmp 656 8 at at IN cord-015306-us58wwmp 656 9 2 2 CD cord-015306-us58wwmp 656 10 - - SYM cord-015306-us58wwmp 656 11 3 3 CD cord-015306-us58wwmp 656 12 years year NNS cord-015306-us58wwmp 656 13 , , , cord-015306-us58wwmp 656 14 following follow VBG cord-015306-us58wwmp 656 15 an an DT cord-015306-us58wwmp 656 16 incidental incidental JJ cord-015306-us58wwmp 656 17 finding finding NN cord-015306-us58wwmp 656 18 in in IN cord-015306-us58wwmp 656 19 abdominal abdominal JJ cord-015306-us58wwmp 656 20 imaging imaging NN cord-015306-us58wwmp 656 21 done do VBN cord-015306-us58wwmp 656 22 for for IN cord-015306-us58wwmp 656 23 different different JJ cord-015306-us58wwmp 656 24 reasons reason NNS cord-015306-us58wwmp 656 25 . . . cord-015306-us58wwmp 657 1 Conclusion conclusion NN cord-015306-us58wwmp 657 2 : : : cord-015306-us58wwmp 657 3 Hepatoblastoma Hepatoblastoma NNP cord-015306-us58wwmp 657 4 has have VBZ cord-015306-us58wwmp 657 5 been be VBN cord-015306-us58wwmp 657 6 reported report VBN cord-015306-us58wwmp 657 7 in in IN cord-015306-us58wwmp 657 8 association association NN cord-015306-us58wwmp 657 9 with with IN cord-015306-us58wwmp 657 10 cystic cystic JJ cord-015306-us58wwmp 657 11 renal renal JJ cord-015306-us58wwmp 657 12 dysplasia dysplasia NN cord-015306-us58wwmp 657 13 in in IN cord-015306-us58wwmp 657 14 5 5 CD cord-015306-us58wwmp 657 15 children child NNS cord-015306-us58wwmp 657 16 in in IN cord-015306-us58wwmp 657 17 the the DT cord-015306-us58wwmp 657 18 literature literature NN cord-015306-us58wwmp 657 19 to to IN cord-015306-us58wwmp 657 20 date date NN cord-015306-us58wwmp 657 21 . . . cord-015306-us58wwmp 658 1 None none NN cord-015306-us58wwmp 658 2 of of IN cord-015306-us58wwmp 658 3 these these DT cord-015306-us58wwmp 658 4 children child NNS cord-015306-us58wwmp 658 5 had have VBD cord-015306-us58wwmp 658 6 evidence evidence NN cord-015306-us58wwmp 658 7 of of IN cord-015306-us58wwmp 658 8 impaired impaired JJ cord-015306-us58wwmp 658 9 renal renal JJ cord-015306-us58wwmp 658 10 function function NN cord-015306-us58wwmp 658 11 prior prior RB cord-015306-us58wwmp 658 12 to to IN cord-015306-us58wwmp 658 13 the the DT cord-015306-us58wwmp 658 14 diagnosis diagnosis NN cord-015306-us58wwmp 658 15 of of IN cord-015306-us58wwmp 658 16 hepatoblastoma hepatoblastoma NNP cord-015306-us58wwmp 658 17 . . . cord-015306-us58wwmp 659 1 In in IN cord-015306-us58wwmp 659 2 our -PRON- PRP$ cord-015306-us58wwmp 659 3 report report NN cord-015306-us58wwmp 659 4 both both CC cord-015306-us58wwmp 659 5 the the DT cord-015306-us58wwmp 659 6 child child NN cord-015306-us58wwmp 659 7 were be VBD cord-015306-us58wwmp 659 8 treated treat VBN cord-015306-us58wwmp 659 9 with with IN cord-015306-us58wwmp 659 10 high high JJ cord-015306-us58wwmp 659 11 dose dose NN cord-015306-us58wwmp 659 12 erythropoietin erythropoietin NN cord-015306-us58wwmp 659 13 prior prior RB cord-015306-us58wwmp 659 14 to to IN cord-015306-us58wwmp 659 15 diagnosis diagnosis NN cord-015306-us58wwmp 659 16 of of IN cord-015306-us58wwmp 659 17 hepatoblastoma hepatoblastoma NNP cord-015306-us58wwmp 659 18 . . . cord-015306-us58wwmp 660 1 Erythropoietin Erythropoietin NNP cord-015306-us58wwmp 660 2 ( ( -LRB- cord-015306-us58wwmp 660 3 Epo Epo NNP cord-015306-us58wwmp 660 4 ) ) -RRB- cord-015306-us58wwmp 660 5 is be VBZ cord-015306-us58wwmp 660 6 the the DT cord-015306-us58wwmp 660 7 primary primary JJ cord-015306-us58wwmp 660 8 regulator regulator NN cord-015306-us58wwmp 660 9 of of IN cord-015306-us58wwmp 660 10 erythropoiesis erythropoiesis NN cord-015306-us58wwmp 660 11 through through IN cord-015306-us58wwmp 660 12 specific specific JJ cord-015306-us58wwmp 660 13 interaction interaction NN cord-015306-us58wwmp 660 14 with with IN cord-015306-us58wwmp 660 15 its -PRON- PRP$ cord-015306-us58wwmp 660 16 receptor receptor NN cord-015306-us58wwmp 660 17 ( ( -LRB- cord-015306-us58wwmp 660 18 Epo Epo NNP cord-015306-us58wwmp 660 19 R R NNP cord-015306-us58wwmp 660 20 ) ) -RRB- cord-015306-us58wwmp 660 21 . . . cord-015306-us58wwmp 661 1 EpoR EpoR NNP cord-015306-us58wwmp 661 2 expression expression NN cord-015306-us58wwmp 661 3 has have VBZ cord-015306-us58wwmp 661 4 been be VBN cord-015306-us58wwmp 661 5 demonstrated demonstrate VBN cord-015306-us58wwmp 661 6 in in IN cord-015306-us58wwmp 661 7 common common JJ cord-015306-us58wwmp 661 8 paediatrictumour paediatrictumour NNP cord-015306-us58wwmp 661 9 cells cell NNS cord-015306-us58wwmp 661 10 and and CC cord-015306-us58wwmp 661 11 such such JJ cord-015306-us58wwmp 661 12 expression expression NN cord-015306-us58wwmp 661 13 is be VBZ cord-015306-us58wwmp 661 14 reported report VBN cord-015306-us58wwmp 661 15 to to TO cord-015306-us58wwmp 661 16 promote promote VB cord-015306-us58wwmp 661 17 tumour tumour NN cord-015306-us58wwmp 661 18 cell cell NN cord-015306-us58wwmp 661 19 survival survival NN cord-015306-us58wwmp 661 20 through through IN cord-015306-us58wwmp 661 21 release release NN cord-015306-us58wwmp 661 22 of of IN cord-015306-us58wwmp 661 23 angiogenic angiogenic JJ cord-015306-us58wwmp 661 24 growth growth NN cord-015306-us58wwmp 661 25 factors factor NNS cord-015306-us58wwmp 661 26 . . . cord-015306-us58wwmp 662 1 Angiogenesis Angiogenesis NNP cord-015306-us58wwmp 662 2 is be VBZ cord-015306-us58wwmp 662 3 the the DT cord-015306-us58wwmp 662 4 primary primary JJ cord-015306-us58wwmp 662 5 requirement requirement NN cord-015306-us58wwmp 662 6 for for IN cord-015306-us58wwmp 662 7 tumour tumour NN cord-015306-us58wwmp 662 8 growth growth NN cord-015306-us58wwmp 662 9 . . . cord-015306-us58wwmp 663 1 Epo Epo NNP cord-015306-us58wwmp 663 2 production production NN cord-015306-us58wwmp 663 3 has have VBZ cord-015306-us58wwmp 663 4 been be VBN cord-015306-us58wwmp 663 5 observed observe VBN cord-015306-us58wwmp 663 6 in in IN cord-015306-us58wwmp 663 7 patients patient NNS cord-015306-us58wwmp 663 8 with with IN cord-015306-us58wwmp 663 9 hepatomas hepatoma NNS cord-015306-us58wwmp 663 10 and and CC cord-015306-us58wwmp 663 11 in in IN cord-015306-us58wwmp 663 12 the the DT cord-015306-us58wwmp 663 13 HepG-2 HepG-2 NNP cord-015306-us58wwmp 663 14 cell cell NN cord-015306-us58wwmp 663 15 line line NN cord-015306-us58wwmp 663 16 in in IN cord-015306-us58wwmp 663 17 hepatoblastoma hepatoblastoma NNP cord-015306-us58wwmp 663 18 . . . cord-015306-us58wwmp 664 1 We -PRON- PRP cord-015306-us58wwmp 664 2 report report VBP cord-015306-us58wwmp 664 3 two two CD cord-015306-us58wwmp 664 4 cases case NNS cord-015306-us58wwmp 664 5 of of IN cord-015306-us58wwmp 664 6 hepatoblastoma hepatoblastoma NNP cord-015306-us58wwmp 664 7 detected detect VBN cord-015306-us58wwmp 664 8 incidentally incidentally RB cord-015306-us58wwmp 664 9 in in IN cord-015306-us58wwmp 664 10 children child NNS cord-015306-us58wwmp 664 11 with with IN cord-015306-us58wwmp 664 12 established established JJ cord-015306-us58wwmp 664 13 renal renal JJ cord-015306-us58wwmp 664 14 failure failure NN cord-015306-us58wwmp 664 15 and and CC cord-015306-us58wwmp 664 16 propose propose VB cord-015306-us58wwmp 664 17 a a DT cord-015306-us58wwmp 664 18 putative putative JJ cord-015306-us58wwmp 664 19 role role NN cord-015306-us58wwmp 664 20 of of IN cord-015306-us58wwmp 664 21 EPO EPO NNP cord-015306-us58wwmp 664 22 in in IN cord-015306-us58wwmp 664 23 the the DT cord-015306-us58wwmp 664 24 development development NN cord-015306-us58wwmp 664 25 and and CC cord-015306-us58wwmp 664 26 / / SYM cord-015306-us58wwmp 664 27 or or CC cord-015306-us58wwmp 664 28 progression progression NN cord-015306-us58wwmp 664 29 of of IN cord-015306-us58wwmp 664 30 hepatoblastoma hepatoblastoma NN cord-015306-us58wwmp 664 31 in in IN cord-015306-us58wwmp 664 32 this this DT cord-015306-us58wwmp 664 33 population population NN cord-015306-us58wwmp 664 34 . . . cord-015306-us58wwmp 665 1 Objective objective NN cord-015306-us58wwmp 665 2 : : : cord-015306-us58wwmp 666 1 Hypercalciuria Hypercalciuria NNP cord-015306-us58wwmp 666 2 is be VBZ cord-015306-us58wwmp 666 3 the the DT cord-015306-us58wwmp 666 4 most most RBS cord-015306-us58wwmp 666 5 common common JJ cord-015306-us58wwmp 666 6 metabolic metabolic JJ cord-015306-us58wwmp 666 7 cause cause NN cord-015306-us58wwmp 666 8 of of IN cord-015306-us58wwmp 666 9 renal renal JJ cord-015306-us58wwmp 666 10 stone stone NN cord-015306-us58wwmp 666 11 . . . cord-015306-us58wwmp 667 1 Long long JJ cord-015306-us58wwmp 667 2 term term NN cord-015306-us58wwmp 667 3 immobilization immobilization NN cord-015306-us58wwmp 667 4 is be VBZ cord-015306-us58wwmp 667 5 associated associate VBN cord-015306-us58wwmp 667 6 with with IN cord-015306-us58wwmp 667 7 hypercalciuria hypercalciuria NN cord-015306-us58wwmp 667 8 and and CC cord-015306-us58wwmp 667 9 bone bone NN cord-015306-us58wwmp 667 10 loss loss NN cord-015306-us58wwmp 667 11 . . . cord-015306-us58wwmp 668 1 The the DT cord-015306-us58wwmp 668 2 effect effect NN cord-015306-us58wwmp 668 3 of of IN cord-015306-us58wwmp 668 4 short short JJ cord-015306-us58wwmp 668 5 term term NN cord-015306-us58wwmp 668 6 immobilization immobilization NN cord-015306-us58wwmp 668 7 on on IN cord-015306-us58wwmp 668 8 hypercalciuria hypercalciuria NNP cord-015306-us58wwmp 668 9 was be VBD cord-015306-us58wwmp 668 10 the the DT cord-015306-us58wwmp 668 11 main main JJ cord-015306-us58wwmp 668 12 objective objective NN cord-015306-us58wwmp 668 13 of of IN cord-015306-us58wwmp 668 14 this this DT cord-015306-us58wwmp 668 15 study study NN cord-015306-us58wwmp 668 16 . . . cord-015306-us58wwmp 669 1 Methods method NNS cord-015306-us58wwmp 669 2 : : : cord-015306-us58wwmp 669 3 In in IN cord-015306-us58wwmp 669 4 a a DT cord-015306-us58wwmp 669 5 prospective prospective JJ cord-015306-us58wwmp 669 6 study study NN cord-015306-us58wwmp 669 7 all all DT cord-015306-us58wwmp 669 8 orthopedic orthopedic JJ cord-015306-us58wwmp 669 9 patients patient NNS cord-015306-us58wwmp 669 10 less less JJR cord-015306-us58wwmp 669 11 than than IN cord-015306-us58wwmp 669 12 40 40 CD cord-015306-us58wwmp 669 13 years year NNS cord-015306-us58wwmp 669 14 with with IN cord-015306-us58wwmp 669 15 pelvic pelvic JJ cord-015306-us58wwmp 669 16 fracture fracture NN cord-015306-us58wwmp 669 17 who who WP cord-015306-us58wwmp 669 18 were be VBD cord-015306-us58wwmp 669 19 assigned assign VBN cord-015306-us58wwmp 669 20 for for IN cord-015306-us58wwmp 669 21 immobilization immobilization NN cord-015306-us58wwmp 669 22 with with IN cord-015306-us58wwmp 669 23 traction traction NN cord-015306-us58wwmp 669 24 were be VBD cord-015306-us58wwmp 669 25 enrolled enrol VBN cord-015306-us58wwmp 669 26 in in IN cord-015306-us58wwmp 669 27 this this DT cord-015306-us58wwmp 669 28 study study NN cord-015306-us58wwmp 669 29 . . . cord-015306-us58wwmp 670 1 Serum serum NN cord-015306-us58wwmp 670 2 ( ( -LRB- cord-015306-us58wwmp 670 3 calcium calcium NN cord-015306-us58wwmp 670 4 , , , cord-015306-us58wwmp 670 5 phosphorous phosphorous JJ cord-015306-us58wwmp 670 6 , , , cord-015306-us58wwmp 670 7 alkaline alkaline JJ cord-015306-us58wwmp 670 8 phosphatase phosphatase NN cord-015306-us58wwmp 670 9 , , , cord-015306-us58wwmp 670 10 sodium sodium NN cord-015306-us58wwmp 670 11 , , , cord-015306-us58wwmp 670 12 potassium potassium NN cord-015306-us58wwmp 670 13 , , , cord-015306-us58wwmp 670 14 uric uric NN cord-015306-us58wwmp 670 15 acid acid NN cord-015306-us58wwmp 670 16 , , , cord-015306-us58wwmp 670 17 BUN bun NN cord-015306-us58wwmp 670 18 , , , cord-015306-us58wwmp 670 19 creatinine)and creatinine)and NN cord-015306-us58wwmp 671 1 fasting fast VBG cord-015306-us58wwmp 671 2 urine urine NN cord-015306-us58wwmp 671 3 calcium calcium NN cord-015306-us58wwmp 671 4 , , , cord-015306-us58wwmp 671 5 creatinine creatinine NN cord-015306-us58wwmp 671 6 , , , cord-015306-us58wwmp 671 7 sodium sodium NN cord-015306-us58wwmp 671 8 , , , cord-015306-us58wwmp 671 9 potassium potassium NN cord-015306-us58wwmp 671 10 and and CC cord-015306-us58wwmp 671 11 uric uric NN cord-015306-us58wwmp 671 12 acid acid NN cord-015306-us58wwmp 671 13 were be VBD cord-015306-us58wwmp 671 14 checked check VBN cord-015306-us58wwmp 671 15 within within IN cord-015306-us58wwmp 671 16 48hours 48hours CD cord-015306-us58wwmp 671 17 of of IN cord-015306-us58wwmp 671 18 hospitalization hospitalization NN cord-015306-us58wwmp 671 19 and and CC cord-015306-us58wwmp 671 20 also also RB cord-015306-us58wwmp 671 21 in in IN cord-015306-us58wwmp 671 22 1st,2nd 1st,2nd CD cord-015306-us58wwmp 671 23 and and CC cord-015306-us58wwmp 671 24 3rd 3rd JJ cord-015306-us58wwmp 671 25 weeks week NNS cord-015306-us58wwmp 671 26 of of IN cord-015306-us58wwmp 671 27 immobilization immobilization NN cord-015306-us58wwmp 671 28 and and CC cord-015306-us58wwmp 671 29 then then RB cord-015306-us58wwmp 671 30 after after IN cord-015306-us58wwmp 671 31 2to 2to CD cord-015306-us58wwmp 671 32 3months 3months NN cord-015306-us58wwmp 671 33 of of IN cord-015306-us58wwmp 671 34 mobilization mobilization NN cord-015306-us58wwmp 671 35 . . . cord-015306-us58wwmp 672 1 Student student NN cord-015306-us58wwmp 672 2 's 's POS cord-015306-us58wwmp 672 3 t t NN cord-015306-us58wwmp 672 4 - - HYPH cord-015306-us58wwmp 672 5 tests test NNS cord-015306-us58wwmp 672 6 used use VBN cord-015306-us58wwmp 672 7 for for IN cord-015306-us58wwmp 672 8 statistical statistical JJ cord-015306-us58wwmp 672 9 analysis analysis NN cord-015306-us58wwmp 672 10 . . . cord-015306-us58wwmp 673 1 Results result NNS cord-015306-us58wwmp 673 2 : : : cord-015306-us58wwmp 674 1 Fifty fifty CD cord-015306-us58wwmp 674 2 five five CD cord-015306-us58wwmp 674 3 patients patient NNS cord-015306-us58wwmp 674 4 45 45 CD cord-015306-us58wwmp 674 5 male male JJ cord-015306-us58wwmp 674 6 and and CC cord-015306-us58wwmp 674 7 10 10 CD cord-015306-us58wwmp 674 8 female female NN cord-015306-us58wwmp 674 9 with with IN cord-015306-us58wwmp 674 10 the the DT cord-015306-us58wwmp 674 11 mean mean JJ cord-015306-us58wwmp 674 12 age age NN cord-015306-us58wwmp 674 13 of of IN cord-015306-us58wwmp 674 14 19.4 19.4 CD cord-015306-us58wwmp 674 15 ± ± CD cord-015306-us58wwmp 674 16 12.7 12.7 CD cord-015306-us58wwmp 674 17 years year NNS cord-015306-us58wwmp 674 18 were be VBD cord-015306-us58wwmp 674 19 studied study VBN cord-015306-us58wwmp 674 20 . . . cord-015306-us58wwmp 675 1 Urine urine NN cord-015306-us58wwmp 675 2 calcium calcium NN cord-015306-us58wwmp 675 3 /creatinine /creatinine . cord-015306-us58wwmp 676 1 ( ( -LRB- cord-015306-us58wwmp 676 2 U U NNP cord-015306-us58wwmp 676 3 Ca Ca NNP cord-015306-us58wwmp 676 4 / / SYM cord-015306-us58wwmp 676 5 Cr cr NN cord-015306-us58wwmp 676 6 ) ) -RRB- cord-015306-us58wwmp 677 1 * * NFP cord-015306-us58wwmp 677 2 ratio ratio NN cord-015306-us58wwmp 677 3 before before IN cord-015306-us58wwmp 677 4 immobilization immobilization NN cord-015306-us58wwmp 677 5 U U NNP cord-015306-us58wwmp 677 6 Ca Ca NNP cord-015306-us58wwmp 677 7 / / SYM cord-015306-us58wwmp 677 8 Cr0 Cr0 NNP cord-015306-us58wwmp 677 9 was be VBD cord-015306-us58wwmp 677 10 0.13±0.06 0.13±0.06 CD cord-015306-us58wwmp 677 11 . . . cord-015306-us58wwmp 678 1 One one CD cord-015306-us58wwmp 678 2 , , , cord-015306-us58wwmp 678 3 two two CD cord-015306-us58wwmp 678 4 and and CC cord-015306-us58wwmp 678 5 3 3 CD cord-015306-us58wwmp 678 6 weeks week NNS cord-015306-us58wwmp 678 7 following follow VBG cord-015306-us58wwmp 678 8 immobilization immobilization NN cord-015306-us58wwmp 678 9 U u NN cord-015306-us58wwmp 679 1 Ca Ca NNP cord-015306-us58wwmp 679 2 / / SYM cord-015306-us58wwmp 679 3 Cr cr NN cord-015306-us58wwmp 679 4 ratio ratio NN cord-015306-us58wwmp 679 5 was be VBD cord-015306-us58wwmp 679 6 0.17±0.11 0.17±0.11 CD cord-015306-us58wwmp 679 7 , , , cord-015306-us58wwmp 680 1 0.22±0.12 0.22±0.12 CD cord-015306-us58wwmp 680 2 and and CC cord-015306-us58wwmp 680 3 0.29±0.17respectively 0.29±0.17respectively RB cord-015306-us58wwmp 680 4 . . . cord-015306-us58wwmp 681 1 Multivariate multivariate JJ cord-015306-us58wwmp 681 2 tests test NNS cord-015306-us58wwmp 681 3 revealed reveal VBD cord-015306-us58wwmp 681 4 a a DT cord-015306-us58wwmp 681 5 significant significant JJ cord-015306-us58wwmp 681 6 rise rise NN cord-015306-us58wwmp 681 7 in in IN cord-015306-us58wwmp 681 8 U U NNP cord-015306-us58wwmp 681 9 Ca Ca NNP cord-015306-us58wwmp 681 10 / / SYM cord-015306-us58wwmp 681 11 Cr cr NN cord-015306-us58wwmp 681 12 ratio ratio NN cord-015306-us58wwmp 681 13 during during IN cord-015306-us58wwmp 681 14 hospital hospital NN cord-015306-us58wwmp 681 15 stay stay NN cord-015306-us58wwmp 681 16 when when WRB cord-015306-us58wwmp 681 17 this this DT cord-015306-us58wwmp 681 18 value value NN cord-015306-us58wwmp 681 19 checked check VBN cord-015306-us58wwmp 681 20 before before IN cord-015306-us58wwmp 681 21 immobilization immobilization NN cord-015306-us58wwmp 681 22 and and CC cord-015306-us58wwmp 681 23 throughout throughout IN cord-015306-us58wwmp 681 24 immobilization immobilization NN cord-015306-us58wwmp 681 25 as as RB cord-015306-us58wwmp 681 26 soon soon RB cord-015306-us58wwmp 681 27 as as IN cord-015306-us58wwmp 681 28 end end NN cord-015306-us58wwmp 681 29 of of IN cord-015306-us58wwmp 681 30 1st 1st JJ cord-015306-us58wwmp 681 31 week week NN cord-015306-us58wwmp 681 32 and and CC cord-015306-us58wwmp 681 33 following follow VBG cord-015306-us58wwmp 681 34 in in IN cord-015306-us58wwmp 681 35 2nd 2nd JJ cord-015306-us58wwmp 681 36 and and CC cord-015306-us58wwmp 681 37 3rd 3rd JJ cord-015306-us58wwmp 681 38 week week NN cord-015306-us58wwmp 682 1 ( ( -LRB- cord-015306-us58wwmp 682 2 Objective objective NN cord-015306-us58wwmp 682 3 : : : cord-015306-us58wwmp 682 4 Importance importance NN cord-015306-us58wwmp 682 5 of of IN cord-015306-us58wwmp 682 6 renal renal JJ cord-015306-us58wwmp 682 7 biopsy(RB biopsy(rb CD cord-015306-us58wwmp 682 8 ) ) -RRB- cord-015306-us58wwmp 682 9 in in IN cord-015306-us58wwmp 682 10 diagnosis diagnosis NN cord-015306-us58wwmp 682 11 and and CC cord-015306-us58wwmp 682 12 treatment treatment NN cord-015306-us58wwmp 682 13 of of IN cord-015306-us58wwmp 682 14 kidney kidney NN cord-015306-us58wwmp 682 15 disease disease NN cord-015306-us58wwmp 682 16 is be VBZ cord-015306-us58wwmp 682 17 the the DT cord-015306-us58wwmp 682 18 same same JJ cord-015306-us58wwmp 682 19 for for IN cord-015306-us58wwmp 682 20 children child NNS cord-015306-us58wwmp 682 21 as as IN cord-015306-us58wwmp 682 22 for for IN cord-015306-us58wwmp 682 23 adults adult NNS cord-015306-us58wwmp 682 24 . . . cord-015306-us58wwmp 683 1 However however RB cord-015306-us58wwmp 683 2 there there EX cord-015306-us58wwmp 683 3 are be VBP cord-015306-us58wwmp 683 4 some some DT cord-015306-us58wwmp 683 5 differences difference NNS cord-015306-us58wwmp 683 6 between between IN cord-015306-us58wwmp 683 7 institutions institution NNS cord-015306-us58wwmp 683 8 in in IN cord-015306-us58wwmp 683 9 practice practice NN cord-015306-us58wwmp 683 10 of of IN cord-015306-us58wwmp 683 11 this this DT cord-015306-us58wwmp 683 12 invasive invasive JJ cord-015306-us58wwmp 683 13 method method NN cord-015306-us58wwmp 683 14 . . . cord-015306-us58wwmp 684 1 The the DT cord-015306-us58wwmp 684 2 aim aim NN cord-015306-us58wwmp 684 3 of of IN cord-015306-us58wwmp 684 4 this this DT cord-015306-us58wwmp 684 5 study study NN cord-015306-us58wwmp 684 6 is be VBZ cord-015306-us58wwmp 684 7 to to TO cord-015306-us58wwmp 684 8 identify identify VB cord-015306-us58wwmp 684 9 the the DT cord-015306-us58wwmp 684 10 current current JJ cord-015306-us58wwmp 684 11 status status NN cord-015306-us58wwmp 684 12 and and CC cord-015306-us58wwmp 684 13 complications complication NNS cord-015306-us58wwmp 684 14 associated associate VBN cord-015306-us58wwmp 684 15 with with IN cord-015306-us58wwmp 684 16 the the DT cord-015306-us58wwmp 684 17 renal renal JJ cord-015306-us58wwmp 684 18 biopsy biopsy NN cord-015306-us58wwmp 684 19 of of IN cord-015306-us58wwmp 684 20 childhood childhood NN cord-015306-us58wwmp 684 21 kidney kidney NN cord-015306-us58wwmp 684 22 disease disease NN cord-015306-us58wwmp 684 23 . . . cord-015306-us58wwmp 685 1 Methods method NNS cord-015306-us58wwmp 685 2 : : : cord-015306-us58wwmp 685 3 A a DT cord-015306-us58wwmp 685 4 retrospective retrospective JJ cord-015306-us58wwmp 685 5 study study NN cord-015306-us58wwmp 685 6 was be VBD cord-015306-us58wwmp 685 7 conducted conduct VBN cord-015306-us58wwmp 685 8 based base VBN cord-015306-us58wwmp 685 9 on on IN cord-015306-us58wwmp 685 10 medical medical JJ cord-015306-us58wwmp 685 11 records record NNS cord-015306-us58wwmp 685 12 from from IN cord-015306-us58wwmp 685 13 all all DT cord-015306-us58wwmp 685 14 patients patient NNS cord-015306-us58wwmp 685 15 who who WP cord-015306-us58wwmp 685 16 had have VBD cord-015306-us58wwmp 685 17 undergone undergo VBN cord-015306-us58wwmp 685 18 native native JJ cord-015306-us58wwmp 685 19 renal renal JJ cord-015306-us58wwmp 685 20 biopsies biopsy NNS cord-015306-us58wwmp 685 21 with with IN cord-015306-us58wwmp 685 22 16-gauge 16-gauge CD cord-015306-us58wwmp 685 23 needles needle NNS cord-015306-us58wwmp 685 24 from from IN cord-015306-us58wwmp 685 25 April April NNP cord-015306-us58wwmp 685 26 1997 1997 CD cord-015306-us58wwmp 685 27 to to IN cord-015306-us58wwmp 685 28 November November NNP cord-015306-us58wwmp 685 29 2012 2012 CD cord-015306-us58wwmp 685 30 in in IN cord-015306-us58wwmp 685 31 our -PRON- PRP$ cord-015306-us58wwmp 685 32 center center NN cord-015306-us58wwmp 685 33 . . . cord-015306-us58wwmp 686 1 We -PRON- PRP cord-015306-us58wwmp 686 2 analyzed analyze VBD cord-015306-us58wwmp 686 3 the the DT cord-015306-us58wwmp 686 4 number number NN cord-015306-us58wwmp 686 5 of of IN cord-015306-us58wwmp 686 6 experiments experiment NNS cord-015306-us58wwmp 686 7 , , , cord-015306-us58wwmp 686 8 sex sex NN cord-015306-us58wwmp 686 9 , , , cord-015306-us58wwmp 686 10 age age NN cord-015306-us58wwmp 686 11 , , , cord-015306-us58wwmp 686 12 indication indication NN cord-015306-us58wwmp 686 13 , , , cord-015306-us58wwmp 686 14 the the DT cord-015306-us58wwmp 686 15 types type NNS cord-015306-us58wwmp 686 16 of of IN cord-015306-us58wwmp 686 17 harvest harvest NN cord-015306-us58wwmp 686 18 ( ( -LRB- cord-015306-us58wwmp 686 19 percutaneous percutaneous JJ cord-015306-us58wwmp 686 20 or or CC cord-015306-us58wwmp 686 21 open open JJ cord-015306-us58wwmp 686 22 ) ) -RRB- cord-015306-us58wwmp 686 23 and and CC cord-015306-us58wwmp 686 24 anesthesia anesthesia NN cord-015306-us58wwmp 686 25 ( ( -LRB- cord-015306-us58wwmp 686 26 general general JJ cord-015306-us58wwmp 686 27 or or CC cord-015306-us58wwmp 686 28 local local JJ cord-015306-us58wwmp 686 29 ) ) -RRB- cord-015306-us58wwmp 686 30 , , , cord-015306-us58wwmp 686 31 histopathological histopathological NNP cord-015306-us58wwmp 686 32 findings finding NNS cord-015306-us58wwmp 686 33 , , , cord-015306-us58wwmp 686 34 and and CC cord-015306-us58wwmp 686 35 complications complication NNS cord-015306-us58wwmp 686 36 . . . cord-015306-us58wwmp 687 1 Results result NNS cord-015306-us58wwmp 687 2 : : : cord-015306-us58wwmp 688 1 A a DT cord-015306-us58wwmp 688 2 total total NN cord-015306-us58wwmp 688 3 of of IN cord-015306-us58wwmp 688 4 158 158 CD cord-015306-us58wwmp 688 5 renal renal JJ cord-015306-us58wwmp 688 6 biopsies biopsy NNS cord-015306-us58wwmp 688 7 were be VBD cord-015306-us58wwmp 688 8 performed perform VBN cord-015306-us58wwmp 688 9 in in IN cord-015306-us58wwmp 688 10 141 141 CD cord-015306-us58wwmp 688 11 patients patient NNS cord-015306-us58wwmp 688 12 ( ( -LRB- cord-015306-us58wwmp 688 13 82 82 CD cord-015306-us58wwmp 688 14 boys boy NNS cord-015306-us58wwmp 688 15 , , , cord-015306-us58wwmp 688 16 59 59 CD cord-015306-us58wwmp 688 17 girls girl NNS cord-015306-us58wwmp 688 18 ) ) -RRB- cord-015306-us58wwmp 688 19 . . . cord-015306-us58wwmp 689 1 The the DT cord-015306-us58wwmp 689 2 mean mean JJ cord-015306-us58wwmp 689 3 age age NN cord-015306-us58wwmp 689 4 at at IN cord-015306-us58wwmp 689 5 first first JJ cord-015306-us58wwmp 689 6 procedure procedure NN cord-015306-us58wwmp 689 7 was be VBD cord-015306-us58wwmp 689 8 9.4 9.4 CD cord-015306-us58wwmp 689 9 years year NNS cord-015306-us58wwmp 689 10 . . . cord-015306-us58wwmp 690 1 About about RB cord-015306-us58wwmp 690 2 70 70 CD cord-015306-us58wwmp 690 3 % % NN cord-015306-us58wwmp 690 4 of of IN cord-015306-us58wwmp 690 5 the the DT cord-015306-us58wwmp 690 6 indications indication NNS cord-015306-us58wwmp 690 7 for for IN cord-015306-us58wwmp 690 8 a a DT cord-015306-us58wwmp 690 9 biopsy biopsy NN cord-015306-us58wwmp 690 10 showed show VBD cord-015306-us58wwmp 690 11 moderate moderate JJ cord-015306-us58wwmp 690 12 proteinuria proteinuria NN cord-015306-us58wwmp 690 13 and and CC cord-015306-us58wwmp 690 14 hematuria hematuria NN cord-015306-us58wwmp 690 15 in in IN cord-015306-us58wwmp 690 16 the the DT cord-015306-us58wwmp 690 17 annual annual JJ cord-015306-us58wwmp 690 18 urinary urinary JJ cord-015306-us58wwmp 690 19 screening screening NN cord-015306-us58wwmp 690 20 program program NN cord-015306-us58wwmp 690 21 in in IN cord-015306-us58wwmp 690 22 Japan Japan NNP cord-015306-us58wwmp 690 23 , , , cord-015306-us58wwmp 690 24 and and CC cord-015306-us58wwmp 690 25 approximately approximately RB cord-015306-us58wwmp 690 26 20 20 CD cord-015306-us58wwmp 690 27 percent percent NN cord-015306-us58wwmp 690 28 of of IN cord-015306-us58wwmp 690 29 those those DT cord-015306-us58wwmp 690 30 were be VBD cord-015306-us58wwmp 690 31 refractory refractory JJ cord-015306-us58wwmp 690 32 childhood childhood NN cord-015306-us58wwmp 690 33 nephrotic nephrotic JJ cord-015306-us58wwmp 690 34 syndrome syndrome NN cord-015306-us58wwmp 690 35 . . . cord-015306-us58wwmp 691 1 Open open JJ cord-015306-us58wwmp 691 2 renal renal JJ cord-015306-us58wwmp 691 3 biopsies biopsy NNS cord-015306-us58wwmp 691 4 were be VBD cord-015306-us58wwmp 691 5 practiced practice VBN cord-015306-us58wwmp 691 6 in in IN cord-015306-us58wwmp 691 7 only only RB cord-015306-us58wwmp 691 8 3 3 CD cord-015306-us58wwmp 691 9 cases case NNS cord-015306-us58wwmp 691 10 , , , cord-015306-us58wwmp 691 11 and and CC cord-015306-us58wwmp 691 12 the the DT cord-015306-us58wwmp 691 13 rest rest NN cord-015306-us58wwmp 691 14 of of IN cord-015306-us58wwmp 691 15 children child NNS cord-015306-us58wwmp 691 16 underwent undergo VBD cord-015306-us58wwmp 691 17 percutaneous percutaneous JJ cord-015306-us58wwmp 691 18 ultrasound ultrasound NN cord-015306-us58wwmp 691 19 - - HYPH cord-015306-us58wwmp 691 20 guided guide VBN cord-015306-us58wwmp 691 21 kidney kidney NN cord-015306-us58wwmp 691 22 biopsies biopsy NNS cord-015306-us58wwmp 691 23 . . . cord-015306-us58wwmp 692 1 The the DT cord-015306-us58wwmp 692 2 most most JJS cord-015306-us58wwmp 692 3 procedures procedure NNS cord-015306-us58wwmp 692 4 of of IN cord-015306-us58wwmp 692 5 patients patient NNS cord-015306-us58wwmp 692 6 aged age VBN cord-015306-us58wwmp 692 7 10 10 CD cord-015306-us58wwmp 692 8 or or CC cord-015306-us58wwmp 692 9 younger young JJR cord-015306-us58wwmp 692 10 were be VBD cord-015306-us58wwmp 692 11 executed execute VBN cord-015306-us58wwmp 692 12 under under IN cord-015306-us58wwmp 692 13 general general JJ cord-015306-us58wwmp 692 14 anesthesia anesthesia NN cord-015306-us58wwmp 692 15 due due IN cord-015306-us58wwmp 692 16 to to IN cord-015306-us58wwmp 692 17 the the DT cord-015306-us58wwmp 692 18 non non JJ cord-015306-us58wwmp 692 19 - - JJ cord-015306-us58wwmp 692 20 cooperation cooperation NN cord-015306-us58wwmp 692 21 of of IN cord-015306-us58wwmp 692 22 them -PRON- PRP cord-015306-us58wwmp 692 23 . . . cord-015306-us58wwmp 693 1 About about RB cord-015306-us58wwmp 693 2 30 30 CD cord-015306-us58wwmp 693 3 % % NN cord-015306-us58wwmp 693 4 of of IN cord-015306-us58wwmp 693 5 the the DT cord-015306-us58wwmp 693 6 biopsy biopsy NN cord-015306-us58wwmp 693 7 - - HYPH cord-015306-us58wwmp 693 8 proven prove VBN cord-015306-us58wwmp 693 9 kidney kidney NN cord-015306-us58wwmp 693 10 diseases disease NNS cord-015306-us58wwmp 693 11 showed show VBD cord-015306-us58wwmp 693 12 immunoglobulin immunoglobulin NN cord-015306-us58wwmp 693 13 A a DT cord-015306-us58wwmp 693 14 nephropathy nephropathy NN cord-015306-us58wwmp 693 15 , , , cord-015306-us58wwmp 693 16 and and CC cord-015306-us58wwmp 693 17 approximately approximately RB cord-015306-us58wwmp 693 18 20 20 CD cord-015306-us58wwmp 693 19 percent percent NN cord-015306-us58wwmp 693 20 of of IN cord-015306-us58wwmp 693 21 those those DT cord-015306-us58wwmp 693 22 were be VBD cord-015306-us58wwmp 693 23 Henoch Henoch NNP cord-015306-us58wwmp 693 24 - - HYPH cord-015306-us58wwmp 693 25 Schonlein Schonlein NNP cord-015306-us58wwmp 693 26 purpura purpura NN cord-015306-us58wwmp 693 27 nephritis nephritis NN cord-015306-us58wwmp 693 28 . . . cord-015306-us58wwmp 694 1 For for IN cord-015306-us58wwmp 694 2 the the DT cord-015306-us58wwmp 694 3 post post JJ cord-015306-us58wwmp 694 4 biopsy biopsy NN cord-015306-us58wwmp 694 5 complications complication NNS cord-015306-us58wwmp 694 6 , , , cord-015306-us58wwmp 694 7 5 5 CD cord-015306-us58wwmp 694 8 out out IN cord-015306-us58wwmp 694 9 of of IN cord-015306-us58wwmp 694 10 all all DT cord-015306-us58wwmp 694 11 performances performance NNS cord-015306-us58wwmp 694 12 administered administer VBD cord-015306-us58wwmp 694 13 hemostatic hemostatic JJ cord-015306-us58wwmp 694 14 agents agent NNS cord-015306-us58wwmp 694 15 for for IN cord-015306-us58wwmp 694 16 moderate moderate JJ cord-015306-us58wwmp 694 17 hematoma hematoma NN cord-015306-us58wwmp 694 18 , , , cord-015306-us58wwmp 694 19 but but CC cord-015306-us58wwmp 694 20 none none NN cord-015306-us58wwmp 694 21 of of IN cord-015306-us58wwmp 694 22 them -PRON- PRP cord-015306-us58wwmp 694 23 required require VBD cord-015306-us58wwmp 694 24 blood blood NN cord-015306-us58wwmp 694 25 transfusion transfusion NN cord-015306-us58wwmp 694 26 or or CC cord-015306-us58wwmp 694 27 surgical surgical JJ cord-015306-us58wwmp 694 28 intervention intervention NN cord-015306-us58wwmp 694 29 . . . cord-015306-us58wwmp 695 1 Conclusion conclusion NN cord-015306-us58wwmp 695 2 : : : cord-015306-us58wwmp 696 1 We -PRON- PRP cord-015306-us58wwmp 696 2 suggested suggest VBD cord-015306-us58wwmp 696 3 that that IN cord-015306-us58wwmp 696 4 renal renal JJ cord-015306-us58wwmp 696 5 biopsy biopsy NN cord-015306-us58wwmp 696 6 could could MD cord-015306-us58wwmp 696 7 be be VB cord-015306-us58wwmp 696 8 supportively supportively RB cord-015306-us58wwmp 696 9 performed perform VBN cord-015306-us58wwmp 696 10 under under IN cord-015306-us58wwmp 696 11 local local JJ cord-015306-us58wwmp 696 12 anesthesia anesthesia NN cord-015306-us58wwmp 696 13 in in IN cord-015306-us58wwmp 696 14 the the DT cord-015306-us58wwmp 696 15 patients patient NNS cord-015306-us58wwmp 696 16 more more JJR cord-015306-us58wwmp 696 17 than than IN cord-015306-us58wwmp 696 18 the the DT cord-015306-us58wwmp 696 19 upper upper JJ cord-015306-us58wwmp 696 20 grades grade NNS cord-015306-us58wwmp 696 21 of of IN cord-015306-us58wwmp 696 22 elementary elementary JJ cord-015306-us58wwmp 696 23 school school NN cord-015306-us58wwmp 696 24 . . . cord-015306-us58wwmp 697 1 In in IN cord-015306-us58wwmp 697 2 addition addition NN cord-015306-us58wwmp 697 3 , , , cord-015306-us58wwmp 697 4 17 17 CD cord-015306-us58wwmp 697 5 patients patient NNS cord-015306-us58wwmp 697 6 aged age VBN cord-015306-us58wwmp 697 7 3 3 CD cord-015306-us58wwmp 697 8 or or CC cord-015306-us58wwmp 697 9 younger young JJR cord-015306-us58wwmp 697 10 , , , cord-015306-us58wwmp 697 11 including include VBG cord-015306-us58wwmp 697 12 12 12 CD cord-015306-us58wwmp 697 13 months month NNS cord-015306-us58wwmp 697 14 , , , cord-015306-us58wwmp 697 15 could could MD cord-015306-us58wwmp 697 16 undergo undergo VB cord-015306-us58wwmp 697 17 the the DT cord-015306-us58wwmp 697 18 percutaneous percutaneous JJ cord-015306-us58wwmp 697 19 ultrasound ultrasound NN cord-015306-us58wwmp 697 20 - - HYPH cord-015306-us58wwmp 697 21 guided guide VBN cord-015306-us58wwmp 697 22 renal renal JJ cord-015306-us58wwmp 697 23 biopsies biopsy NNS cord-015306-us58wwmp 697 24 without without IN cord-015306-us58wwmp 697 25 procedural procedural JJ cord-015306-us58wwmp 697 26 and and CC cord-015306-us58wwmp 697 27 general general JJ cord-015306-us58wwmp 697 28 anesthesia anesthesia NN cord-015306-us58wwmp 697 29 complications complication NNS cord-015306-us58wwmp 697 30 . . . cord-015306-us58wwmp 698 1 Therefore therefore RB cord-015306-us58wwmp 698 2 , , , cord-015306-us58wwmp 698 3 our -PRON- PRP$ cord-015306-us58wwmp 698 4 results result NNS cord-015306-us58wwmp 698 5 revealed reveal VBD cord-015306-us58wwmp 698 6 that that IN cord-015306-us58wwmp 698 7 this this DT cord-015306-us58wwmp 698 8 procedure procedure NN cord-015306-us58wwmp 698 9 was be VBD cord-015306-us58wwmp 698 10 considered consider VBN cord-015306-us58wwmp 698 11 safe safe JJ cord-015306-us58wwmp 698 12 even even RB cord-015306-us58wwmp 698 13 in in IN cord-015306-us58wwmp 698 14 infants infant NNS cord-015306-us58wwmp 698 15 . . . cord-015306-us58wwmp 699 1 Abstract abstract JJ cord-015306-us58wwmp 699 2 # # NN cord-015306-us58wwmp 699 3 P p NN cord-015306-us58wwmp 699 4 - - HYPH cord-015306-us58wwmp 699 5 SAT084 SAT084 NNP cord-015306-us58wwmp 700 1 Fifteen fifteen CD cord-015306-us58wwmp 700 2 years year NNS cord-015306-us58wwmp 700 3 review review NN cord-015306-us58wwmp 700 4 of of IN cord-015306-us58wwmp 700 5 indications indication NNS cord-015306-us58wwmp 700 6 and and CC cord-015306-us58wwmp 700 7 results result NNS cord-015306-us58wwmp 700 8 of of IN cord-015306-us58wwmp 700 9 renal renal JJ cord-015306-us58wwmp 700 10 biopsy biopsy NN cord-015306-us58wwmp 700 11 in in IN cord-015306-us58wwmp 700 12 children child NNS cord-015306-us58wwmp 700 13 from from IN cord-015306-us58wwmp 700 14 a a DT cord-015306-us58wwmp 700 15 single single JJ cord-015306-us58wwmp 700 16 center center NN cord-015306-us58wwmp 700 17 in in IN cord-015306-us58wwmp 700 18 Egypt Egypt NNP cord-015306-us58wwmp 701 1 There there EX cord-015306-us58wwmp 701 2 were be VBD cord-015306-us58wwmp 701 3 20 20 CD cord-015306-us58wwmp 701 4 insufficient insufficient JJ cord-015306-us58wwmp 701 5 biopsies biopsy NNS cord-015306-us58wwmp 701 6 . . . cord-015306-us58wwmp 702 1 In in IN cord-015306-us58wwmp 702 2 pathologically pathologically RB cord-015306-us58wwmp 702 3 diagnosed diagnose VBN cord-015306-us58wwmp 702 4 1226 1226 CD cord-015306-us58wwmp 702 5 specimens specimen NNS cord-015306-us58wwmp 702 6 primary primary JJ cord-015306-us58wwmp 702 7 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 702 8 was be VBD cord-015306-us58wwmp 702 9 the the DT cord-015306-us58wwmp 702 10 most most RBS cord-015306-us58wwmp 702 11 common common JJ cord-015306-us58wwmp 702 12 finding finding NN cord-015306-us58wwmp 702 13 ( ( -LRB- cord-015306-us58wwmp 702 14 n=826 n=826 NNP cord-015306-us58wwmp 702 15 , , , cord-015306-us58wwmp 702 16 67.4 67.4 CD cord-015306-us58wwmp 702 17 % % NN cord-015306-us58wwmp 702 18 ) ) -RRB- cord-015306-us58wwmp 702 19 followed follow VBN cord-015306-us58wwmp 702 20 by by IN cord-015306-us58wwmp 702 21 secondary secondary JJ cord-015306-us58wwmp 702 22 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 702 23 ( ( -LRB- cord-015306-us58wwmp 702 24 n=238 n=238 UH cord-015306-us58wwmp 702 25 , , , cord-015306-us58wwmp 702 26 19.4 19.4 CD cord-015306-us58wwmp 702 27 % % NN cord-015306-us58wwmp 702 28 ) ) -RRB- cord-015306-us58wwmp 702 29 and and CC cord-015306-us58wwmp 702 30 end end NN cord-015306-us58wwmp 702 31 stage stage NN cord-015306-us58wwmp 702 32 renal renal JJ cord-015306-us58wwmp 702 33 disease disease NN cord-015306-us58wwmp 702 34 ( ( -LRB- cord-015306-us58wwmp 702 35 n=50 n=50 NN cord-015306-us58wwmp 702 36 , , , cord-015306-us58wwmp 702 37 4.1 4.1 CD cord-015306-us58wwmp 702 38 % % NN cord-015306-us58wwmp 702 39 ) ) -RRB- cord-015306-us58wwmp 702 40 . . . cord-015306-us58wwmp 703 1 The the DT cord-015306-us58wwmp 703 2 most most RBS cord-015306-us58wwmp 703 3 common common JJ cord-015306-us58wwmp 703 4 causes cause NNS cord-015306-us58wwmp 703 5 of of IN cord-015306-us58wwmp 703 6 primary primary JJ cord-015306-us58wwmp 703 7 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 703 8 were be VBD cord-015306-us58wwmp 703 9 minimal minimal JJ cord-015306-us58wwmp 703 10 change change NN cord-015306-us58wwmp 703 11 disease disease NN cord-015306-us58wwmp 703 12 ( ( -LRB- cord-015306-us58wwmp 703 13 n=267 n=267 NNP cord-015306-us58wwmp 703 14 , , , cord-015306-us58wwmp 703 15 21.8 21.8 CD cord-015306-us58wwmp 703 16 % % NN cord-015306-us58wwmp 703 17 ) ) -RRB- cord-015306-us58wwmp 703 18 , , , cord-015306-us58wwmp 703 19 diffuse diffuse VBP cord-015306-us58wwmp 703 20 proliferative proliferative JJ cord-015306-us58wwmp 703 21 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 703 22 ( ( -LRB- cord-015306-us58wwmp 703 23 n=188 n=188 NNP cord-015306-us58wwmp 703 24 , , , cord-015306-us58wwmp 703 25 15.3 15.3 CD cord-015306-us58wwmp 703 26 % % NN cord-015306-us58wwmp 703 27 ) ) -RRB- cord-015306-us58wwmp 703 28 , , , cord-015306-us58wwmp 703 29 focal focal JJ cord-015306-us58wwmp 703 30 proliferative proliferative JJ cord-015306-us58wwmp 703 31 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 703 32 ( ( -LRB- cord-015306-us58wwmp 703 33 n=164 n=164 NNP cord-015306-us58wwmp 703 34 , , , cord-015306-us58wwmp 703 35 13.3 13.3 CD cord-015306-us58wwmp 703 36 % % NN cord-015306-us58wwmp 703 37 ) ) -RRB- cord-015306-us58wwmp 703 38 and and CC cord-015306-us58wwmp 703 39 focal focal JJ cord-015306-us58wwmp 703 40 segmental segmental JJ cord-015306-us58wwmp 703 41 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 703 42 ( ( -LRB- cord-015306-us58wwmp 703 43 n=129 n=129 NNPS cord-015306-us58wwmp 703 44 , , , cord-015306-us58wwmp 703 45 10.5 10.5 CD cord-015306-us58wwmp 703 46 % % NN cord-015306-us58wwmp 703 47 ) ) -RRB- cord-015306-us58wwmp 703 48 . . . cord-015306-us58wwmp 704 1 Lupus lupus NN cord-015306-us58wwmp 704 2 nephritis nephritis NN cord-015306-us58wwmp 704 3 ( ( -LRB- cord-015306-us58wwmp 704 4 n=209 n=209 NNP cord-015306-us58wwmp 704 5 , , , cord-015306-us58wwmp 704 6 17 17 CD cord-015306-us58wwmp 704 7 % % NN cord-015306-us58wwmp 704 8 ) ) -RRB- cord-015306-us58wwmp 704 9 was be VBD cord-015306-us58wwmp 704 10 the the DT cord-015306-us58wwmp 704 11 most most RBS cord-015306-us58wwmp 704 12 common common JJ cord-015306-us58wwmp 704 13 cause cause NN cord-015306-us58wwmp 704 14 of of IN cord-015306-us58wwmp 704 15 secondary secondary JJ cord-015306-us58wwmp 704 16 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 704 17 followed follow VBN cord-015306-us58wwmp 704 18 by by IN cord-015306-us58wwmp 704 19 hemolytic hemolytic JJ cord-015306-us58wwmp 704 20 uremic uremic JJ cord-015306-us58wwmp 704 21 syndrome syndrome NN cord-015306-us58wwmp 704 22 ( ( -LRB- cord-015306-us58wwmp 704 23 n=16 n=16 NNP cord-015306-us58wwmp 704 24 , , , cord-015306-us58wwmp 704 25 1.3 1.3 CD cord-015306-us58wwmp 704 26 % % NN cord-015306-us58wwmp 704 27 ) ) -RRB- cord-015306-us58wwmp 704 28 and and CC cord-015306-us58wwmp 704 29 amyloidosis amyloidosis NN cord-015306-us58wwmp 704 30 ( ( -LRB- cord-015306-us58wwmp 704 31 n=10 n=10 NNP cord-015306-us58wwmp 704 32 , , , cord-015306-us58wwmp 704 33 0.8 0.8 CD cord-015306-us58wwmp 704 34 % % NN cord-015306-us58wwmp 704 35 ) ) -RRB- cord-015306-us58wwmp 704 36 . . . cord-015306-us58wwmp 705 1 Only only RB cord-015306-us58wwmp 705 2 one one CD cord-015306-us58wwmp 705 3 mortality mortality NN cord-015306-us58wwmp 705 4 has have VBZ cord-015306-us58wwmp 705 5 been be VBN cord-015306-us58wwmp 705 6 reported report VBN cord-015306-us58wwmp 705 7 as as IN cord-015306-us58wwmp 705 8 a a DT cord-015306-us58wwmp 705 9 complication complication NN cord-015306-us58wwmp 705 10 of of IN cord-015306-us58wwmp 705 11 renal renal JJ cord-015306-us58wwmp 705 12 biopsy biopsy NN cord-015306-us58wwmp 705 13 ( ( -LRB- cord-015306-us58wwmp 705 14 uncontrolled uncontrolled JJ cord-015306-us58wwmp 705 15 bleeding bleeding NN cord-015306-us58wwmp 705 16 ) ) -RRB- cord-015306-us58wwmp 705 17 . . . cord-015306-us58wwmp 706 1 Conclusion conclusion NN cord-015306-us58wwmp 706 2 : : : cord-015306-us58wwmp 707 1 This this DT cord-015306-us58wwmp 707 2 study study NN cord-015306-us58wwmp 707 3 introduces introduce VBZ cord-015306-us58wwmp 707 4 the the DT cord-015306-us58wwmp 707 5 first first JJ cord-015306-us58wwmp 707 6 biopsy biopsy NN cord-015306-us58wwmp 707 7 based base VBN cord-015306-us58wwmp 707 8 epidemiological epidemiological JJ cord-015306-us58wwmp 707 9 information information NN cord-015306-us58wwmp 707 10 of of IN cord-015306-us58wwmp 707 11 pattern pattern NN cord-015306-us58wwmp 707 12 of of IN cord-015306-us58wwmp 707 13 renal renal JJ cord-015306-us58wwmp 707 14 diseases disease NNS cord-015306-us58wwmp 707 15 in in IN cord-015306-us58wwmp 707 16 Egyptian egyptian JJ cord-015306-us58wwmp 707 17 children child NNS cord-015306-us58wwmp 707 18 from from IN cord-015306-us58wwmp 707 19 a a DT cord-015306-us58wwmp 707 20 single single JJ cord-015306-us58wwmp 707 21 tertiary tertiary JJ cord-015306-us58wwmp 707 22 pediatric pediatric JJ cord-015306-us58wwmp 707 23 center center NN cord-015306-us58wwmp 707 24 in in IN cord-015306-us58wwmp 707 25 which which WDT cord-015306-us58wwmp 707 26 minimal minimal JJ cord-015306-us58wwmp 707 27 change change NN cord-015306-us58wwmp 707 28 disease disease NN cord-015306-us58wwmp 707 29 was be VBD cord-015306-us58wwmp 707 30 the the DT cord-015306-us58wwmp 707 31 most most RBS cord-015306-us58wwmp 707 32 common common JJ cord-015306-us58wwmp 707 33 histopathological histopathological JJ cord-015306-us58wwmp 707 34 finding finding NN cord-015306-us58wwmp 707 35 and and CC cord-015306-us58wwmp 707 36 steroid steroid JJ cord-015306-us58wwmp 707 37 resistant resistant JJ cord-015306-us58wwmp 707 38 nephrotic nephrotic JJ cord-015306-us58wwmp 707 39 syndrome syndrome NN cord-015306-us58wwmp 707 40 was be VBD cord-015306-us58wwmp 707 41 the the DT cord-015306-us58wwmp 707 42 most most RBS cord-015306-us58wwmp 707 43 frequent frequent JJ cord-015306-us58wwmp 707 44 indication indication NN cord-015306-us58wwmp 707 45 for for IN cord-015306-us58wwmp 707 46 biopsy biopsy NN cord-015306-us58wwmp 707 47 . . . cord-015306-us58wwmp 708 1 Results result NNS cord-015306-us58wwmp 708 2 : : : cord-015306-us58wwmp 709 1 A a DT cord-015306-us58wwmp 709 2 total total NN cord-015306-us58wwmp 709 3 of of IN cord-015306-us58wwmp 709 4 112 112 CD cord-015306-us58wwmp 709 5 children child NNS cord-015306-us58wwmp 709 6 were be VBD cord-015306-us58wwmp 709 7 enrolled enrol VBN cord-015306-us58wwmp 709 8 in in IN cord-015306-us58wwmp 709 9 the the DT cord-015306-us58wwmp 709 10 study study NN cord-015306-us58wwmp 709 11 . . . cord-015306-us58wwmp 710 1 Most Most JJS cord-015306-us58wwmp 710 2 of of IN cord-015306-us58wwmp 710 3 them -PRON- PRP cord-015306-us58wwmp 710 4 ( ( -LRB- cord-015306-us58wwmp 710 5 71 71 CD cord-015306-us58wwmp 710 6 % % NN cord-015306-us58wwmp 710 7 ) ) -RRB- cord-015306-us58wwmp 710 8 had have VBD cord-015306-us58wwmp 710 9 isolated isolate VBN cord-015306-us58wwmp 710 10 microhematuria microhematuria NNP cord-015306-us58wwmp 710 11 , , , cord-015306-us58wwmp 710 12 and and CC cord-015306-us58wwmp 710 13 were be VBD cord-015306-us58wwmp 710 14 proved prove VBN cord-015306-us58wwmp 710 15 mild mild JJ cord-015306-us58wwmp 710 16 lesion lesion NN cord-015306-us58wwmp 710 17 of of IN cord-015306-us58wwmp 710 18 glomeruli glomerulus NNS cord-015306-us58wwmp 710 19 ( ( -LRB- cord-015306-us58wwmp 710 20 60 60 CD cord-015306-us58wwmp 710 21 % % NN cord-015306-us58wwmp 710 22 ) ) -RRB- cord-015306-us58wwmp 710 23 by by IN cord-015306-us58wwmp 710 24 renal renal JJ cord-015306-us58wwmp 710 25 biopsy biopsy NN cord-015306-us58wwmp 710 26 . . . cord-015306-us58wwmp 711 1 About about RB cord-015306-us58wwmp 711 2 30 30 CD cord-015306-us58wwmp 711 3 % % NN cord-015306-us58wwmp 711 4 of of IN cord-015306-us58wwmp 711 5 them -PRON- PRP cord-015306-us58wwmp 711 6 , , , cord-015306-us58wwmp 711 7 however however RB cord-015306-us58wwmp 711 8 , , , cord-015306-us58wwmp 711 9 might may MD cord-015306-us58wwmp 711 10 have have VB cord-015306-us58wwmp 711 11 progressive progressive JJ cord-015306-us58wwmp 711 12 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 711 13 , , , cord-015306-us58wwmp 711 14 such such JJ cord-015306-us58wwmp 711 15 as as IN cord-015306-us58wwmp 711 16 IgA IgA NNP cord-015306-us58wwmp 711 17 nephropathy nephropathy NN cord-015306-us58wwmp 711 18 , , , cord-015306-us58wwmp 711 19 focal focal JJ cord-015306-us58wwmp 711 20 segmental segmental JJ cord-015306-us58wwmp 711 21 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 711 22 , , , cord-015306-us58wwmp 711 23 Alport Alport NNP cord-015306-us58wwmp 711 24 syndrome syndrome NN cord-015306-us58wwmp 711 25 and and CC cord-015306-us58wwmp 711 26 so so RB cord-015306-us58wwmp 711 27 on on RB cord-015306-us58wwmp 711 28 . . . cord-015306-us58wwmp 712 1 These these DT cord-015306-us58wwmp 712 2 asymptomatic asymptomatic JJ cord-015306-us58wwmp 712 3 children child NNS cord-015306-us58wwmp 712 4 were be VBD cord-015306-us58wwmp 712 5 found find VBN cord-015306-us58wwmp 712 6 urine urine NN cord-015306-us58wwmp 712 7 abnormalities abnormality NNS cord-015306-us58wwmp 712 8 due due JJ cord-015306-us58wwmp 712 9 to to IN cord-015306-us58wwmp 712 10 either either CC cord-015306-us58wwmp 712 11 school school NN cord-015306-us58wwmp 712 12 urine urine NN cord-015306-us58wwmp 712 13 screening screening NN cord-015306-us58wwmp 712 14 study study NN cord-015306-us58wwmp 712 15 , , , cord-015306-us58wwmp 712 16 health health NN cord-015306-us58wwmp 712 17 examination examination NN cord-015306-us58wwmp 712 18 , , , cord-015306-us58wwmp 712 19 or or CC cord-015306-us58wwmp 712 20 during during IN cord-015306-us58wwmp 712 21 diagnosis diagnosis NN cord-015306-us58wwmp 712 22 of of IN cord-015306-us58wwmp 712 23 non non JJ cord-015306-us58wwmp 712 24 - - JJ cord-015306-us58wwmp 712 25 renal renal JJ cord-015306-us58wwmp 712 26 diseases disease NNS cord-015306-us58wwmp 712 27 . . . cord-015306-us58wwmp 713 1 In in IN cord-015306-us58wwmp 713 2 center center NN cord-015306-us58wwmp 713 3 A A NNP cord-015306-us58wwmp 713 4 , , , cord-015306-us58wwmp 713 5 IgA IgA NNP cord-015306-us58wwmp 713 6 nephropathy nephropathy NN cord-015306-us58wwmp 713 7 was be VBD cord-015306-us58wwmp 713 8 the the DT cord-015306-us58wwmp 713 9 most most JJS cord-015306-us58wwmp 713 10 case case NN cord-015306-us58wwmp 713 11 diagnosed diagnose VBN cord-015306-us58wwmp 713 12 , , , cord-015306-us58wwmp 713 13 while while IN cord-015306-us58wwmp 713 14 in in IN cord-015306-us58wwmp 713 15 center center NN cord-015306-us58wwmp 713 16 B B NNP cord-015306-us58wwmp 713 17 and and CC cord-015306-us58wwmp 713 18 C C NNP cord-015306-us58wwmp 713 19 , , , cord-015306-us58wwmp 713 20 minor minor JJ cord-015306-us58wwmp 713 21 glomerular glomerular JJ cord-015306-us58wwmp 713 22 abnormalities abnormality NNS cord-015306-us58wwmp 713 23 was be VBD cord-015306-us58wwmp 713 24 the the DT cord-015306-us58wwmp 713 25 most most JJS cord-015306-us58wwmp 713 26 case case NN cord-015306-us58wwmp 713 27 diagnosed diagnose VBN cord-015306-us58wwmp 713 28 . . . cord-015306-us58wwmp 714 1 The the DT cord-015306-us58wwmp 714 2 difference difference NN cord-015306-us58wwmp 714 3 among among IN cord-015306-us58wwmp 714 4 three three CD cord-015306-us58wwmp 714 5 centers center NNS cord-015306-us58wwmp 714 6 was be VBD cord-015306-us58wwmp 714 7 significant significant JJ cord-015306-us58wwmp 714 8 and and CC cord-015306-us58wwmp 714 9 this this DT cord-015306-us58wwmp 714 10 variation variation NN cord-015306-us58wwmp 714 11 might may MD cord-015306-us58wwmp 714 12 be be VB cord-015306-us58wwmp 714 13 due due JJ cord-015306-us58wwmp 714 14 to to IN cord-015306-us58wwmp 714 15 different different JJ cord-015306-us58wwmp 714 16 indications indication NNS cord-015306-us58wwmp 714 17 of of IN cord-015306-us58wwmp 714 18 renal renal JJ cord-015306-us58wwmp 714 19 biopsy biopsy NN cord-015306-us58wwmp 714 20 . . . cord-015306-us58wwmp 715 1 Conclusion conclusion NN cord-015306-us58wwmp 715 2 : : : cord-015306-us58wwmp 716 1 Our -PRON- PRP$ cord-015306-us58wwmp 716 2 findings finding NNS cord-015306-us58wwmp 716 3 confirm confirm VBP cord-015306-us58wwmp 716 4 that that IN cord-015306-us58wwmp 716 5 urinalysis urinalysis NN cord-015306-us58wwmp 716 6 may may MD cord-015306-us58wwmp 716 7 help help VB cord-015306-us58wwmp 716 8 early early RB cord-015306-us58wwmp 716 9 detecting detect VBG cord-015306-us58wwmp 716 10 progressive progressive JJ cord-015306-us58wwmp 716 11 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 716 12 in in IN cord-015306-us58wwmp 716 13 asymptomatic asymptomatic JJ cord-015306-us58wwmp 716 14 children child NNS cord-015306-us58wwmp 716 15 . . . cord-015306-us58wwmp 717 1 Children child NNS cord-015306-us58wwmp 717 2 with with IN cord-015306-us58wwmp 717 3 isolated isolated JJ cord-015306-us58wwmp 717 4 microhematuria microhematuria NNP cord-015306-us58wwmp 717 5 has have VBZ cord-015306-us58wwmp 717 6 relatively relatively RB cord-015306-us58wwmp 717 7 low low JJ cord-015306-us58wwmp 717 8 risk risk NN cord-015306-us58wwmp 717 9 of of IN cord-015306-us58wwmp 717 10 severe severe JJ cord-015306-us58wwmp 717 11 pathologic pathologic JJ cord-015306-us58wwmp 717 12 lesion lesion NN cord-015306-us58wwmp 717 13 of of IN cord-015306-us58wwmp 717 14 glomeruli glomerulus NNS cord-015306-us58wwmp 717 15 , , , cord-015306-us58wwmp 717 16 thus thus RB cord-015306-us58wwmp 717 17 isolated isolate VBN cord-015306-us58wwmp 717 18 microhematuria microhematuria NNP cord-015306-us58wwmp 717 19 per per FW cord-015306-us58wwmp 717 20 se se FW cord-015306-us58wwmp 717 21 might may MD cord-015306-us58wwmp 717 22 not not RB cord-015306-us58wwmp 717 23 be be VB cord-015306-us58wwmp 717 24 suggested suggest VBN cord-015306-us58wwmp 717 25 as as IN cord-015306-us58wwmp 717 26 indication indication NN cord-015306-us58wwmp 717 27 of of IN cord-015306-us58wwmp 717 28 early early JJ cord-015306-us58wwmp 717 29 renal renal JJ cord-015306-us58wwmp 717 30 biopsy biopsy NN cord-015306-us58wwmp 717 31 . . . cord-015306-us58wwmp 718 1 Long long JJ cord-015306-us58wwmp 718 2 - - HYPH cord-015306-us58wwmp 718 3 term term NN cord-015306-us58wwmp 718 4 follow follow NN cord-015306-us58wwmp 718 5 - - HYPH cord-015306-us58wwmp 718 6 up up NN cord-015306-us58wwmp 718 7 with with IN cord-015306-us58wwmp 718 8 appropriate appropriate JJ cord-015306-us58wwmp 718 9 further further JJ cord-015306-us58wwmp 718 10 examination examination NN cord-015306-us58wwmp 718 11 is be VBZ cord-015306-us58wwmp 718 12 of of IN cord-015306-us58wwmp 718 13 great great JJ cord-015306-us58wwmp 718 14 importance importance NN cord-015306-us58wwmp 718 15 for for IN cord-015306-us58wwmp 718 16 these these DT cord-015306-us58wwmp 718 17 asymptomatic asymptomatic JJ cord-015306-us58wwmp 718 18 children child NNS cord-015306-us58wwmp 718 19 . . . cord-015306-us58wwmp 719 1 Abstract abstract JJ cord-015306-us58wwmp 719 2 # # NN cord-015306-us58wwmp 719 3 P p NN cord-015306-us58wwmp 719 4 - - , cord-015306-us58wwmp 719 5 SAT089 SAT089 NNP cord-015306-us58wwmp 719 6 Twenty Twenty NNP cord-015306-us58wwmp 719 7 - - HYPH cord-015306-us58wwmp 719 8 three three CD cord-015306-us58wwmp 719 9 - - HYPH cord-015306-us58wwmp 719 10 year year NN cord-015306-us58wwmp 719 11 review review NN cord-015306-us58wwmp 719 12 of of IN cord-015306-us58wwmp 719 13 disease disease NN cord-015306-us58wwmp 719 14 patterns pattern NNS cord-015306-us58wwmp 719 15 from from IN cord-015306-us58wwmp 719 16 renal renal JJ cord-015306-us58wwmp 719 17 biopsies biopsy NNS cord-015306-us58wwmp 719 18 : : : cord-015306-us58wwmp 719 19 an an DT cord-015306-us58wwmp 719 20 experience experience NN cord-015306-us58wwmp 719 21 from from IN cord-015306-us58wwmp 719 22 a a DT cord-015306-us58wwmp 719 23 pediatric pediatric JJ cord-015306-us58wwmp 719 24 renal renal JJ cord-015306-us58wwmp 719 25 center center NN cord-015306-us58wwmp 720 1 There there EX cord-015306-us58wwmp 720 2 were be VBD cord-015306-us58wwmp 720 3 59 59 CD cord-015306-us58wwmp 720 4 episode episode NN cord-015306-us58wwmp 720 5 of of IN cord-015306-us58wwmp 720 6 peritonitis peritonitis NN cord-015306-us58wwmp 720 7 with with IN cord-015306-us58wwmp 720 8 an an DT cord-015306-us58wwmp 720 9 incidence incidence NN cord-015306-us58wwmp 720 10 of of IN cord-015306-us58wwmp 720 11 1 1 CD cord-015306-us58wwmp 720 12 episode episode NN cord-015306-us58wwmp 720 13 per per IN cord-015306-us58wwmp 720 14 16.8 16.8 CD cord-015306-us58wwmp 720 15 patient patient NN cord-015306-us58wwmp 720 16 / / SYM cord-015306-us58wwmp 720 17 months month NNS cord-015306-us58wwmp 720 18 . . . cord-015306-us58wwmp 721 1 The the DT cord-015306-us58wwmp 721 2 commonest common JJS cord-015306-us58wwmp 721 3 organisms organism NNS cord-015306-us58wwmp 721 4 isolated isolate VBN cord-015306-us58wwmp 721 5 were be VBD cord-015306-us58wwmp 721 6 gram gram JJ cord-015306-us58wwmp 721 7 negative negative JJ cord-015306-us58wwmp 721 8 rods rod NNS cord-015306-us58wwmp 721 9 12(20.3 12(20.3 CD cord-015306-us58wwmp 721 10 % % NN cord-015306-us58wwmp 721 11 ) ) -RRB- cord-015306-us58wwmp 721 12 , , , cord-015306-us58wwmp 721 13 followed follow VBN cord-015306-us58wwmp 721 14 by by IN cord-015306-us58wwmp 721 15 staph staph NN cord-015306-us58wwmp 721 16 aureus aureus NNP cord-015306-us58wwmp 721 17 11(18.6 11(18.6 CD cord-015306-us58wwmp 721 18 % % NN cord-015306-us58wwmp 721 19 ) ) -RRB- cord-015306-us58wwmp 721 20 . . . cord-015306-us58wwmp 722 1 Sixteen sixteen CD cord-015306-us58wwmp 722 2 ( ( -LRB- cord-015306-us58wwmp 722 3 27.1 27.1 CD cord-015306-us58wwmp 722 4 % % NN cord-015306-us58wwmp 722 5 ) ) -RRB- cord-015306-us58wwmp 722 6 were be VBD cord-015306-us58wwmp 722 7 culture culture NN cord-015306-us58wwmp 722 8 negative negative JJ cord-015306-us58wwmp 722 9 and and CC cord-015306-us58wwmp 722 10 3(5.1 3(5.1 CD cord-015306-us58wwmp 722 11 % % NN cord-015306-us58wwmp 722 12 ) ) -RRB- cord-015306-us58wwmp 722 13 were be VBD cord-015306-us58wwmp 722 14 fungal fungal JJ cord-015306-us58wwmp 722 15 peritonitis peritonitis NN cord-015306-us58wwmp 722 16 . . . cord-015306-us58wwmp 723 1 Catheter catheter NN cord-015306-us58wwmp 723 2 removal removal NN cord-015306-us58wwmp 723 3 related relate VBN cord-015306-us58wwmp 723 4 to to IN cord-015306-us58wwmp 723 5 peritonitis peritonitis NN cord-015306-us58wwmp 723 6 was be VBD cord-015306-us58wwmp 723 7 performed perform VBN cord-015306-us58wwmp 723 8 in in IN cord-015306-us58wwmp 723 9 20 20 CD cord-015306-us58wwmp 723 10 patients patient NNS cord-015306-us58wwmp 723 11 in in IN cord-015306-us58wwmp 723 12 whom whom WP cord-015306-us58wwmp 723 13 only only RB cord-015306-us58wwmp 723 14 one one CD cord-015306-us58wwmp 723 15 patient patient NN cord-015306-us58wwmp 723 16 returned return VBD cord-015306-us58wwmp 723 17 back back RB cord-015306-us58wwmp 723 18 to to IN cord-015306-us58wwmp 723 19 PD PD NNP cord-015306-us58wwmp 723 20 . . . cord-015306-us58wwmp 724 1 Exit exit NN cord-015306-us58wwmp 724 2 site site NN cord-015306-us58wwmp 724 3 infection infection NN cord-015306-us58wwmp 724 4 ( ( -LRB- cord-015306-us58wwmp 724 5 21 21 CD cord-015306-us58wwmp 724 6 episodes episode NNS cord-015306-us58wwmp 724 7 ) ) -RRB- cord-015306-us58wwmp 724 8 and and CC cord-015306-us58wwmp 724 9 tunnel tunnel NN cord-015306-us58wwmp 724 10 infection infection NN cord-015306-us58wwmp 724 11 were be VBD cord-015306-us58wwmp 724 12 reported report VBN cord-015306-us58wwmp 724 13 in in IN cord-015306-us58wwmp 724 14 20 20 CD cord-015306-us58wwmp 724 15 and and CC cord-015306-us58wwmp 724 16 10 10 CD cord-015306-us58wwmp 724 17 patients patient NNS cord-015306-us58wwmp 724 18 respectively respectively RB cord-015306-us58wwmp 724 19 . . . cord-015306-us58wwmp 725 1 Catheter catheter NN cord-015306-us58wwmp 725 2 malfunction malfunction NN cord-015306-us58wwmp 725 3 was be VBD cord-015306-us58wwmp 725 4 the the DT cord-015306-us58wwmp 725 5 most most RBS cord-015306-us58wwmp 725 6 common common JJ cord-015306-us58wwmp 725 7 non non AFX cord-015306-us58wwmp 725 8 infectious infectious JJ cord-015306-us58wwmp 725 9 complication complication NN cord-015306-us58wwmp 725 10 seen see VBN cord-015306-us58wwmp 725 11 in in IN cord-015306-us58wwmp 725 12 27 27 CD cord-015306-us58wwmp 725 13 ( ( -LRB- cord-015306-us58wwmp 725 14 61.3 61.3 CD cord-015306-us58wwmp 725 15 % % NN cord-015306-us58wwmp 725 16 ) ) -RRB- cord-015306-us58wwmp 725 17 children child NNS cord-015306-us58wwmp 725 18 . . . cord-015306-us58wwmp 726 1 Other other JJ cord-015306-us58wwmp 726 2 noninfectious noninfectious JJ cord-015306-us58wwmp 726 3 complications complication NNS cord-015306-us58wwmp 726 4 include include VBP cord-015306-us58wwmp 726 5 haemorrahgic haemorrahgic NN cord-015306-us58wwmp 726 6 effluent effluent NN cord-015306-us58wwmp 726 7 5 5 CD cord-015306-us58wwmp 726 8 ( ( -LRB- cord-015306-us58wwmp 726 9 11.3 11.3 CD cord-015306-us58wwmp 726 10 % % NN cord-015306-us58wwmp 726 11 ) ) -RRB- cord-015306-us58wwmp 726 12 children child NNS cord-015306-us58wwmp 726 13 while while IN cord-015306-us58wwmp 726 14 Catheter Catheter NNP cord-015306-us58wwmp 726 15 leak leak NN cord-015306-us58wwmp 726 16 , , , cord-015306-us58wwmp 726 17 umbilical umbilical JJ cord-015306-us58wwmp 726 18 hernia hernia NN cord-015306-us58wwmp 726 19 and and CC cord-015306-us58wwmp 726 20 inflow inflow JJ cord-015306-us58wwmp 726 21 pain pain NN cord-015306-us58wwmp 726 22 where where WRB cord-015306-us58wwmp 726 23 seen see VBN cord-015306-us58wwmp 726 24 in in IN cord-015306-us58wwmp 726 25 2 2 CD cord-015306-us58wwmp 726 26 ( ( -LRB- cord-015306-us58wwmp 726 27 4.5 4.5 CD cord-015306-us58wwmp 726 28 % % NN cord-015306-us58wwmp 726 29 ) ) -RRB- cord-015306-us58wwmp 726 30 children child NNS cord-015306-us58wwmp 726 31 each each DT cord-015306-us58wwmp 726 32 . . . cord-015306-us58wwmp 727 1 At at IN cord-015306-us58wwmp 727 2 the the DT cord-015306-us58wwmp 727 3 end end NN cord-015306-us58wwmp 727 4 of of IN cord-015306-us58wwmp 727 5 the the DT cord-015306-us58wwmp 727 6 study study NN cord-015306-us58wwmp 727 7 17 17 CD cord-015306-us58wwmp 727 8 ( ( -LRB- cord-015306-us58wwmp 727 9 18.7 18.7 CD cord-015306-us58wwmp 727 10 % % NN cord-015306-us58wwmp 727 11 ) ) -RRB- cord-015306-us58wwmp 727 12 children child NNS cord-015306-us58wwmp 727 13 remained remain VBD cord-015306-us58wwmp 727 14 PD PD NNP cord-015306-us58wwmp 727 15 active active JJ cord-015306-us58wwmp 727 16 , , , cord-015306-us58wwmp 727 17 26 26 CD cord-015306-us58wwmp 727 18 ( ( -LRB- cord-015306-us58wwmp 727 19 28.6 28.6 CD cord-015306-us58wwmp 727 20 % % NN cord-015306-us58wwmp 727 21 ) ) -RRB- cord-015306-us58wwmp 727 22 transferred transfer VBN cord-015306-us58wwmp 727 23 to to IN cord-015306-us58wwmp 727 24 HD HD NNP cord-015306-us58wwmp 727 25 , , , cord-015306-us58wwmp 727 26 13(14.3 13(14.3 CD cord-015306-us58wwmp 727 27 % % NN cord-015306-us58wwmp 727 28 ) ) -RRB- cord-015306-us58wwmp 727 29 transplanted transplant VBN cord-015306-us58wwmp 727 30 , , , cord-015306-us58wwmp 727 31 9(9.9 9(9.9 CD cord-015306-us58wwmp 727 32 % % NN cord-015306-us58wwmp 727 33 ) ) -RRB- cord-015306-us58wwmp 727 34 suspended suspend VBN cord-015306-us58wwmp 727 35 from from IN cord-015306-us58wwmp 727 36 PD PD NNP cord-015306-us58wwmp 727 37 , , , cord-015306-us58wwmp 727 38 5(5.5 5(5.5 JJ cord-015306-us58wwmp 727 39 % % NN cord-015306-us58wwmp 727 40 ) ) -RRB- cord-015306-us58wwmp 727 41 lost lose VBN cord-015306-us58wwmp 727 42 follow follow NN cord-015306-us58wwmp 727 43 up up IN cord-015306-us58wwmp 727 44 and and CC cord-015306-us58wwmp 727 45 21(23.1 21(23.1 CD cord-015306-us58wwmp 727 46 % % NN cord-015306-us58wwmp 727 47 ) ) -RRB- cord-015306-us58wwmp 727 48 children child NNS cord-015306-us58wwmp 727 49 died die VBD cord-015306-us58wwmp 727 50 . . . cord-015306-us58wwmp 728 1 Conclusion conclusion NN cord-015306-us58wwmp 728 2 : : : cord-015306-us58wwmp 729 1 In in IN cord-015306-us58wwmp 729 2 the the DT cord-015306-us58wwmp 729 3 setting setting NN cord-015306-us58wwmp 729 4 of of IN cord-015306-us58wwmp 729 5 our -PRON- PRP$ cord-015306-us58wwmp 729 6 country country NN cord-015306-us58wwmp 729 7 with with IN cord-015306-us58wwmp 729 8 limited limited JJ cord-015306-us58wwmp 729 9 resources resource NNS cord-015306-us58wwmp 729 10 and and CC cord-015306-us58wwmp 729 11 investment investment NN cord-015306-us58wwmp 729 12 , , , cord-015306-us58wwmp 729 13 CAPD CAPD NNP cord-015306-us58wwmp 729 14 is be VBZ cord-015306-us58wwmp 729 15 efficient efficient JJ cord-015306-us58wwmp 729 16 and and CC cord-015306-us58wwmp 729 17 successful successful JJ cord-015306-us58wwmp 729 18 with with IN cord-015306-us58wwmp 729 19 complications complication NNS cord-015306-us58wwmp 729 20 comparable comparable JJ cord-015306-us58wwmp 729 21 to to IN cord-015306-us58wwmp 729 22 most most JJS cord-015306-us58wwmp 729 23 parts part NNS cord-015306-us58wwmp 729 24 of of IN cord-015306-us58wwmp 729 25 the the DT cord-015306-us58wwmp 729 26 world world NN cord-015306-us58wwmp 729 27 . . . cord-015306-us58wwmp 730 1 Attempts attempt NNS cord-015306-us58wwmp 730 2 to to TO cord-015306-us58wwmp 730 3 produce produce VB cord-015306-us58wwmp 730 4 PD PD NNP cord-015306-us58wwmp 730 5 fluids fluid NNS cord-015306-us58wwmp 730 6 locally locally RB cord-015306-us58wwmp 730 7 and and CC cord-015306-us58wwmp 730 8 to to TO cord-015306-us58wwmp 730 9 train train VB cord-015306-us58wwmp 730 10 and and CC cord-015306-us58wwmp 730 11 educate educate VB cord-015306-us58wwmp 730 12 health health NN cord-015306-us58wwmp 730 13 care care NN cord-015306-us58wwmp 730 14 workers worker NNS cord-015306-us58wwmp 730 15 will will MD cord-015306-us58wwmp 730 16 greatly greatly RB cord-015306-us58wwmp 730 17 improve improve VB cord-015306-us58wwmp 730 18 the the DT cord-015306-us58wwmp 730 19 use use NN cord-015306-us58wwmp 730 20 of of IN cord-015306-us58wwmp 730 21 PD PD NNP cord-015306-us58wwmp 730 22 in in IN cord-015306-us58wwmp 730 23 developing develop VBG cord-015306-us58wwmp 730 24 countries country NNS cord-015306-us58wwmp 730 25 . . . cord-015306-us58wwmp 731 1 profile profile NN cord-015306-us58wwmp 731 2 and and CC cord-015306-us58wwmp 731 3 response response NN cord-015306-us58wwmp 731 4 to to IN cord-015306-us58wwmp 731 5 therapy therapy NN cord-015306-us58wwmp 731 6 in in IN cord-015306-us58wwmp 731 7 patients patient NNS cord-015306-us58wwmp 731 8 with with IN cord-015306-us58wwmp 731 9 idiopathic idiopathic JJ cord-015306-us58wwmp 731 10 membranous membranous JJ cord-015306-us58wwmp 731 11 nephropathy nephropathy NN cord-015306-us58wwmp 731 12 from from IN cord-015306-us58wwmp 731 13 March March NNP cord-015306-us58wwmp 731 14 2010 2010 CD cord-015306-us58wwmp 731 15 to to IN cord-015306-us58wwmp 731 16 December December NNP cord-015306-us58wwmp 731 17 2012 2012 CD cord-015306-us58wwmp 731 18 . . . cord-015306-us58wwmp 732 1 Renal renal JJ cord-015306-us58wwmp 732 2 biopsies biopsy NNS cord-015306-us58wwmp 732 3 were be VBD cord-015306-us58wwmp 732 4 studied study VBN cord-015306-us58wwmp 732 5 for for IN cord-015306-us58wwmp 732 6 light light JJ cord-015306-us58wwmp 732 7 microscopy microscopy NN cord-015306-us58wwmp 732 8 , , , cord-015306-us58wwmp 732 9 immunofluorescence immunofluorescence NN cord-015306-us58wwmp 732 10 and and CC cord-015306-us58wwmp 732 11 electron electron NN cord-015306-us58wwmp 732 12 microscopy microscopy NN cord-015306-us58wwmp 732 13 . . . cord-015306-us58wwmp 733 1 Antibodies antibody NNS cord-015306-us58wwmp 733 2 to to IN cord-015306-us58wwmp 733 3 the the DT cord-015306-us58wwmp 733 4 M M NNP cord-015306-us58wwmp 733 5 - - HYPH cord-015306-us58wwmp 733 6 type type NN cord-015306-us58wwmp 733 7 phospholipase phospholipase NN cord-015306-us58wwmp 733 8 A2 A2 NNP cord-015306-us58wwmp 733 9 receptor receptor NN cord-015306-us58wwmp 733 10 ( ( -LRB- cord-015306-us58wwmp 733 11 PLA2R pla2r NN cord-015306-us58wwmp 733 12 ) ) -RRB- cord-015306-us58wwmp 733 13 , , , cord-015306-us58wwmp 733 14 bovine bovine JJ cord-015306-us58wwmp 733 15 serum serum NN cord-015306-us58wwmp 733 16 albumin albumin NN cord-015306-us58wwmp 733 17 ( ( -LRB- cord-015306-us58wwmp 733 18 BSA BSA NNP cord-015306-us58wwmp 733 19 ) ) -RRB- cord-015306-us58wwmp 733 20 , , , cord-015306-us58wwmp 733 21 and and CC cord-015306-us58wwmp 733 22 cationic cationic JJ cord-015306-us58wwmp 733 23 BSA BSA NNP cord-015306-us58wwmp 733 24 were be VBD cord-015306-us58wwmp 733 25 measured measure VBN cord-015306-us58wwmp 733 26 by by IN cord-015306-us58wwmp 733 27 Western western JJ cord-015306-us58wwmp 733 28 blotting blot VBG cord-015306-us58wwmp 733 29 with with IN cord-015306-us58wwmp 733 30 patient patient NN cord-015306-us58wwmp 733 31 sera sera NNP cord-015306-us58wwmp 733 32 ( ( -LRB- cord-015306-us58wwmp 733 33 when when WRB cord-015306-us58wwmp 733 34 available available JJ cord-015306-us58wwmp 733 35 ) ) -RRB- cord-015306-us58wwmp 733 36 and and CC cord-015306-us58wwmp 733 37 then then RB cord-015306-us58wwmp 733 38 detecting detect VBG cord-015306-us58wwmp 733 39 for for IN cord-015306-us58wwmp 733 40 both both DT cord-015306-us58wwmp 733 41 totalIgG totaligg XX cord-015306-us58wwmp 733 42 as as RB cord-015306-us58wwmp 733 43 well well RB cord-015306-us58wwmp 733 44 as as IN cord-015306-us58wwmp 733 45 specifically specifically RB cord-015306-us58wwmp 733 46 for for IN cord-015306-us58wwmp 733 47 the the DT cord-015306-us58wwmp 733 48 IgG4 igg4 CD cord-015306-us58wwmp 733 49 subclass subclass NN cord-015306-us58wwmp 733 50 . . . cord-015306-us58wwmp 734 1 Results result NNS cord-015306-us58wwmp 734 2 : : : cord-015306-us58wwmp 735 1 80 80 CD cord-015306-us58wwmp 735 2 renal renal JJ cord-015306-us58wwmp 735 3 biopsies biopsy NNS cord-015306-us58wwmp 735 4 were be VBD cord-015306-us58wwmp 735 5 performed perform VBN cord-015306-us58wwmp 735 6 during during IN cord-015306-us58wwmp 735 7 the the DT cord-015306-us58wwmp 735 8 study study NN cord-015306-us58wwmp 735 9 period period NN cord-015306-us58wwmp 735 10 , , , cord-015306-us58wwmp 735 11 out out IN cord-015306-us58wwmp 735 12 of of IN cord-015306-us58wwmp 735 13 which which WDT cord-015306-us58wwmp 735 14 11 11 CD cord-015306-us58wwmp 735 15 patients patient NNS cord-015306-us58wwmp 735 16 had have VBD cord-015306-us58wwmp 735 17 membranous membranous JJ cord-015306-us58wwmp 735 18 nephropathy nephropathy NN cord-015306-us58wwmp 735 19 . . . cord-015306-us58wwmp 736 1 Five five CD cord-015306-us58wwmp 736 2 were be VBD cord-015306-us58wwmp 736 3 secondary secondary JJ cord-015306-us58wwmp 736 4 to to IN cord-015306-us58wwmp 736 5 SLE SLE NNP cord-015306-us58wwmp 736 6 and and CC cord-015306-us58wwmp 736 7 6 6 CD cord-015306-us58wwmp 736 8 patients patient NNS cord-015306-us58wwmp 736 9 ( ( -LRB- cord-015306-us58wwmp 736 10 7.5 7.5 CD cord-015306-us58wwmp 736 11 % % NN cord-015306-us58wwmp 736 12 ) ) -RRB- cord-015306-us58wwmp 736 13 had have VBD cord-015306-us58wwmp 736 14 idiopathic idiopathic JJ cord-015306-us58wwmp 736 15 membranous membranous JJ cord-015306-us58wwmp 736 16 nephropathy nephropathy NN cord-015306-us58wwmp 736 17 . . . cord-015306-us58wwmp 737 1 Mean mean JJ cord-015306-us58wwmp 737 2 age age NN cord-015306-us58wwmp 737 3 at at IN cord-015306-us58wwmp 737 4 presentation presentation NN cord-015306-us58wwmp 737 5 was be VBD cord-015306-us58wwmp 737 6 13.16+/-1.94 13.16+/-1.94 CD cord-015306-us58wwmp 737 7 years year NNS cord-015306-us58wwmp 737 8 with with IN cord-015306-us58wwmp 737 9 50 50 CD cord-015306-us58wwmp 737 10 % % NN cord-015306-us58wwmp 737 11 having have VBG cord-015306-us58wwmp 737 12 hematuria hematuria NN cord-015306-us58wwmp 737 13 and and CC cord-015306-us58wwmp 737 14 66.6 66.6 CD cord-015306-us58wwmp 737 15 % % NN cord-015306-us58wwmp 737 16 hypertension hypertension NN cord-015306-us58wwmp 737 17 at at IN cord-015306-us58wwmp 737 18 presentation presentation NN cord-015306-us58wwmp 737 19 . . . cord-015306-us58wwmp 738 1 Estimated estimate VBN cord-015306-us58wwmp 738 2 GFR GFR NNP cord-015306-us58wwmp 738 3 was be VBD cord-015306-us58wwmp 738 4 160.57+/-49.33 160.57+/-49.33 CD cord-015306-us58wwmp 738 5 . . . cord-015306-us58wwmp 739 1 Renal renal JJ cord-015306-us58wwmp 739 2 biopsy biopsy NN cord-015306-us58wwmp 739 3 showed show VBD cord-015306-us58wwmp 739 4 findings finding NNS cord-015306-us58wwmp 739 5 consistent consistent JJ cord-015306-us58wwmp 739 6 with with IN cord-015306-us58wwmp 739 7 membranous membranous JJ cord-015306-us58wwmp 739 8 nephropathy nephropathy NN cord-015306-us58wwmp 739 9 on on IN cord-015306-us58wwmp 739 10 light light JJ cord-015306-us58wwmp 739 11 microscopy microscopy NN cord-015306-us58wwmp 739 12 with with IN cord-015306-us58wwmp 739 13 with<5 with<5 JJ cord-015306-us58wwmp 739 14 % % NN cord-015306-us58wwmp 739 15 of of IN cord-015306-us58wwmp 739 16 the the DT cord-015306-us58wwmp 739 17 interstitium interstitium NN cord-015306-us58wwmp 739 18 showing show VBG cord-015306-us58wwmp 739 19 tubular tubular JJ cord-015306-us58wwmp 739 20 atrophy atrophy NN cord-015306-us58wwmp 739 21 and and CC cord-015306-us58wwmp 739 22 interstitial interstitial JJ cord-015306-us58wwmp 739 23 fibrosis fibrosis NN cord-015306-us58wwmp 739 24 . . . cord-015306-us58wwmp 740 1 Immunofluorescence Immunofluorescence NNP cord-015306-us58wwmp 740 2 studies study NNS cord-015306-us58wwmp 740 3 showed show VBD cord-015306-us58wwmp 740 4 granular granular JJ cord-015306-us58wwmp 740 5 IgG igg NN cord-015306-us58wwmp 740 6 and and CC cord-015306-us58wwmp 740 7 C3 C3 NNP cord-015306-us58wwmp 740 8 along along IN cord-015306-us58wwmp 740 9 the the DT cord-015306-us58wwmp 740 10 peripheral peripheral JJ cord-015306-us58wwmp 740 11 capillary capillary JJ cord-015306-us58wwmp 740 12 walls wall NNS cord-015306-us58wwmp 740 13 . . . cord-015306-us58wwmp 741 1 Electron electron NN cord-015306-us58wwmp 741 2 microscopy microscopy NNS cord-015306-us58wwmp 741 3 showed show VBD cord-015306-us58wwmp 741 4 subepithelial subepithelial JJ cord-015306-us58wwmp 741 5 deposits deposit NNS cord-015306-us58wwmp 741 6 , , , cord-015306-us58wwmp 741 7 with with IN cord-015306-us58wwmp 741 8 formation formation NN cord-015306-us58wwmp 741 9 of of IN cord-015306-us58wwmp 741 10 basement basement NN cord-015306-us58wwmp 741 11 membrane membrane NN cord-015306-us58wwmp 741 12 spikes spike NNS cord-015306-us58wwmp 741 13 between between IN cord-015306-us58wwmp 741 14 the the DT cord-015306-us58wwmp 741 15 deposits deposit NNS cord-015306-us58wwmp 741 16 . . . cord-015306-us58wwmp 742 1 Few few JJ cord-015306-us58wwmp 742 2 intramembranous intramembranous JJ cord-015306-us58wwmp 742 3 deposits deposit NNS cord-015306-us58wwmp 742 4 were be VBD cord-015306-us58wwmp 742 5 also also RB cord-015306-us58wwmp 742 6 present present JJ cord-015306-us58wwmp 742 7 . . . cord-015306-us58wwmp 743 1 Subendothelial subendothelial JJ cord-015306-us58wwmp 743 2 and and CC cord-015306-us58wwmp 743 3 mesangial mesangial JJ cord-015306-us58wwmp 743 4 deposits deposit NNS cord-015306-us58wwmp 743 5 were be VBD cord-015306-us58wwmp 743 6 not not RB cord-015306-us58wwmp 743 7 present present JJ cord-015306-us58wwmp 743 8 . . . cord-015306-us58wwmp 744 1 There there EX cord-015306-us58wwmp 744 2 were be VBD cord-015306-us58wwmp 744 3 no no DT cord-015306-us58wwmp 744 4 antibodies antibody NNS cord-015306-us58wwmp 744 5 to to IN cord-015306-us58wwmp 744 6 BSA BSA NNP cord-015306-us58wwmp 744 7 or or CC cord-015306-us58wwmp 744 8 cationic cationic JJ cord-015306-us58wwmp 744 9 BSA BSA NNP cord-015306-us58wwmp 744 10 detected detect VBD cord-015306-us58wwmp 744 11 in in IN cord-015306-us58wwmp 744 12 any any DT cord-015306-us58wwmp 744 13 of of IN cord-015306-us58wwmp 744 14 the the DT cord-015306-us58wwmp 744 15 five five CD cord-015306-us58wwmp 744 16 sera sera NNP cord-015306-us58wwmp 744 17 available available JJ cord-015306-us58wwmp 744 18 . . . cord-015306-us58wwmp 745 1 One one CD cord-015306-us58wwmp 745 2 of of IN cord-015306-us58wwmp 745 3 the the DT cord-015306-us58wwmp 745 4 five five CD cord-015306-us58wwmp 745 5 patients patient NNS cord-015306-us58wwmp 745 6 had have VBD cord-015306-us58wwmp 745 7 circulating circulate VBG cord-015306-us58wwmp 745 8 antibodies antibody NNS cord-015306-us58wwmp 745 9 to to IN cord-015306-us58wwmp 745 10 PLA2R. pla2r. XX cord-015306-us58wwmp 746 1 All all DT cord-015306-us58wwmp 746 2 patients patient NNS cord-015306-us58wwmp 746 3 received receive VBD cord-015306-us58wwmp 746 4 prednisolone prednisolone NN cord-015306-us58wwmp 746 5 , , , cord-015306-us58wwmp 746 6 angiotensin angiotensin NN cord-015306-us58wwmp 746 7 converting convert VBG cord-015306-us58wwmp 746 8 enzyme enzyme NN cord-015306-us58wwmp 746 9 inhibitors inhibitor NNS cord-015306-us58wwmp 746 10 and and CC cord-015306-us58wwmp 746 11 oral oral JJ cord-015306-us58wwmp 746 12 calcium calcium NN cord-015306-us58wwmp 746 13 supplements supplement NNS cord-015306-us58wwmp 746 14 . . . cord-015306-us58wwmp 747 1 Two two CD cord-015306-us58wwmp 747 2 patients patient NNS cord-015306-us58wwmp 747 3 continued continue VBD cord-015306-us58wwmp 747 4 to to TO cord-015306-us58wwmp 747 5 have have VB cord-015306-us58wwmp 747 6 nephrotic nephrotic JJ cord-015306-us58wwmp 747 7 range range NN cord-015306-us58wwmp 747 8 proteinuria proteinuria NN cord-015306-us58wwmp 747 9 inspite inspite JJ cord-015306-us58wwmp 747 10 of of IN cord-015306-us58wwmp 747 11 prednisolone prednisolone NN cord-015306-us58wwmp 747 12 and and CC cord-015306-us58wwmp 747 13 were be VBD cord-015306-us58wwmp 747 14 started start VBN cord-015306-us58wwmp 747 15 on on IN cord-015306-us58wwmp 747 16 cyclosporine cyclosporine NN cord-015306-us58wwmp 747 17 . . . cord-015306-us58wwmp 748 1 None none NN cord-015306-us58wwmp 748 2 of of IN cord-015306-us58wwmp 748 3 the the DT cord-015306-us58wwmp 748 4 patients patient NNS cord-015306-us58wwmp 748 5 developed develop VBD cord-015306-us58wwmp 748 6 any any DT cord-015306-us58wwmp 748 7 complications complication NNS cord-015306-us58wwmp 748 8 . . . cord-015306-us58wwmp 749 1 Conclusion conclusion NN cord-015306-us58wwmp 749 2 : : : cord-015306-us58wwmp 750 1 Immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 750 2 therapy therapy NN cord-015306-us58wwmp 750 3 is be VBZ cord-015306-us58wwmp 750 4 beneficial beneficial JJ cord-015306-us58wwmp 750 5 in in IN cord-015306-us58wwmp 750 6 children child NNS cord-015306-us58wwmp 750 7 with with IN cord-015306-us58wwmp 750 8 idiopathic idiopathic JJ cord-015306-us58wwmp 750 9 membranous membranous JJ cord-015306-us58wwmp 750 10 nephropathy nephropathy NN cord-015306-us58wwmp 750 11 . . . cord-015306-us58wwmp 751 1 Anti anti JJ cord-015306-us58wwmp 751 2 - - JJ cord-015306-us58wwmp 751 3 PLA2R pla2r JJ cord-015306-us58wwmp 751 4 antibodies antibody NNS cord-015306-us58wwmp 751 5 can can MD cord-015306-us58wwmp 751 6 be be VB cord-015306-us58wwmp 751 7 seen see VBN cord-015306-us58wwmp 751 8 as as RB cord-015306-us58wwmp 751 9 early early RB cord-015306-us58wwmp 751 10 as as IN cord-015306-us58wwmp 751 11 13 13 CD cord-015306-us58wwmp 751 12 years year NNS cord-015306-us58wwmp 751 13 of of IN cord-015306-us58wwmp 751 14 age age NN cord-015306-us58wwmp 751 15 . . . cord-015306-us58wwmp 752 1 Abstract abstract JJ cord-015306-us58wwmp 752 2 # # NN cord-015306-us58wwmp 752 3 P p NN cord-015306-us58wwmp 752 4 - - HYPH cord-015306-us58wwmp 752 5 SAT108 SAT108 NNP cord-015306-us58wwmp 752 6 Hypercalcemic Hypercalcemic NNP cord-015306-us58wwmp 752 7 crisis crisis NN cord-015306-us58wwmp 752 8 and and CC cord-015306-us58wwmp 752 9 nephrogenic nephrogenic NNP cord-015306-us58wwmp 752 10 diabetes diabetes NN cord-015306-us58wwmp 752 11 insipidus insipidus NN cord-015306-us58wwmp 752 12 due due IN cord-015306-us58wwmp 752 13 to to IN cord-015306-us58wwmp 752 14 vitamin vitamin NN cord-015306-us58wwmp 752 15 D d NN cord-015306-us58wwmp 752 16 intoxication intoxication NN cord-015306-us58wwmp 752 17 Methods method NNS cord-015306-us58wwmp 752 18 : : : cord-015306-us58wwmp 752 19 Twenty twenty CD cord-015306-us58wwmp 752 20 - - HYPH cord-015306-us58wwmp 752 21 three three CD cord-015306-us58wwmp 752 22 children child NNS cord-015306-us58wwmp 752 23 ( ( -LRB- cord-015306-us58wwmp 752 24 46 46 CD cord-015306-us58wwmp 752 25 kidneys kidney NNS cord-015306-us58wwmp 752 26 ) ) -RRB- cord-015306-us58wwmp 752 27 with with IN cord-015306-us58wwmp 752 28 first first JJ cord-015306-us58wwmp 752 29 UTI UTI NNP cord-015306-us58wwmp 752 30 with with IN cord-015306-us58wwmp 752 31 P-fimbriatedE.coli P-fimbriatedE.coli NNP cord-015306-us58wwmp 752 32 were be VBD cord-015306-us58wwmp 752 33 enrolled enrol VBN cord-015306-us58wwmp 752 34 in in IN cord-015306-us58wwmp 752 35 the the DT cord-015306-us58wwmp 752 36 study study NN cord-015306-us58wwmp 752 37 . . . cord-015306-us58wwmp 753 1 Children child NNS cord-015306-us58wwmp 753 2 were be VBD cord-015306-us58wwmp 753 3 aged age VBN cord-015306-us58wwmp 753 4 between between IN cord-015306-us58wwmp 753 5 few few JJ cord-015306-us58wwmp 753 6 months month NNS cord-015306-us58wwmp 753 7 and and CC cord-015306-us58wwmp 753 8 10 10 CD cord-015306-us58wwmp 753 9 years year NNS cord-015306-us58wwmp 753 10 . . . cord-015306-us58wwmp 754 1 All all DT cord-015306-us58wwmp 754 2 children child NNS cord-015306-us58wwmp 754 3 were be VBD cord-015306-us58wwmp 754 4 treated treat VBN cord-015306-us58wwmp 754 5 with with IN cord-015306-us58wwmp 754 6 adequate adequate JJ cord-015306-us58wwmp 754 7 antibiotic antibiotic JJ cord-015306-us58wwmp 754 8 therapy therapy NN cord-015306-us58wwmp 754 9 . . . cord-015306-us58wwmp 755 1 DMSA DMSA NNP cord-015306-us58wwmp 755 2 scintigraphy scintigraphy NNP cord-015306-us58wwmp 755 3 was be VBD cord-015306-us58wwmp 755 4 performed perform VBN cord-015306-us58wwmp 755 5 in in IN cord-015306-us58wwmp 755 6 a a DT cord-015306-us58wwmp 755 7 few few JJ cord-015306-us58wwmp 755 8 days day NNS cord-015306-us58wwmp 755 9 after after IN cord-015306-us58wwmp 755 10 infection infection NN cord-015306-us58wwmp 755 11 and and CC cord-015306-us58wwmp 755 12 control control NN cord-015306-us58wwmp 755 13 scintigraphy scintigraphy NNP cord-015306-us58wwmp 755 14 was be VBD cord-015306-us58wwmp 755 15 performed perform VBN cord-015306-us58wwmp 755 16 5 5 CD cord-015306-us58wwmp 755 17 months month NNS cord-015306-us58wwmp 755 18 to to IN cord-015306-us58wwmp 755 19 36 36 CD cord-015306-us58wwmp 755 20 months month NNS cord-015306-us58wwmp 755 21 later later RB cord-015306-us58wwmp 755 22 . . . cord-015306-us58wwmp 756 1 DMSA DMSA NNP cord-015306-us58wwmp 756 2 findings finding NNS cord-015306-us58wwmp 756 3 were be VBD cord-015306-us58wwmp 756 4 categorised categorise VBN cord-015306-us58wwmp 756 5 as as IN cord-015306-us58wwmp 756 6 normal normal JJ cord-015306-us58wwmp 756 7 , , , cord-015306-us58wwmp 756 8 generally generally RB cord-015306-us58wwmp 756 9 diminished diminish VBN cord-015306-us58wwmp 756 10 uptake uptake NN cord-015306-us58wwmp 756 11 of of IN cord-015306-us58wwmp 756 12 activity activity NN cord-015306-us58wwmp 756 13 , , , cord-015306-us58wwmp 756 14 focally focally RB cord-015306-us58wwmp 756 15 diminished diminished JJ cord-015306-us58wwmp 756 16 uptake uptake NN cord-015306-us58wwmp 756 17 of of IN cord-015306-us58wwmp 756 18 activity activity NN cord-015306-us58wwmp 756 19 and and CC cord-015306-us58wwmp 756 20 clearly clearly RB cord-015306-us58wwmp 756 21 pathologic pathologic JJ cord-015306-us58wwmp 756 22 with with IN cord-015306-us58wwmp 756 23 renal renal JJ cord-015306-us58wwmp 756 24 scars scar NNS cord-015306-us58wwmp 756 25 . . . cord-015306-us58wwmp 757 1 Results result NNS cord-015306-us58wwmp 757 2 : : : cord-015306-us58wwmp 758 1 The the DT cord-015306-us58wwmp 758 2 first first JJ cord-015306-us58wwmp 758 3 DMSA DMSA NNS cord-015306-us58wwmp 758 4 scintigraphy scintigraphy NN cord-015306-us58wwmp 758 5 immediately immediately RB cord-015306-us58wwmp 758 6 after after IN cord-015306-us58wwmp 758 7 infection infection NN cord-015306-us58wwmp 758 8 was be VBD cord-015306-us58wwmp 758 9 normal normal JJ cord-015306-us58wwmp 758 10 in in IN cord-015306-us58wwmp 758 11 12 12 CD cord-015306-us58wwmp 758 12 kidneys kidney NNS cord-015306-us58wwmp 758 13 ( ( -LRB- cord-015306-us58wwmp 758 14 26.1 26.1 CD cord-015306-us58wwmp 758 15 % % NN cord-015306-us58wwmp 758 16 ) ) -RRB- cord-015306-us58wwmp 758 17 , , , cord-015306-us58wwmp 758 18 generally generally RB cord-015306-us58wwmp 758 19 diminished diminish VBN cord-015306-us58wwmp 758 20 activity activity NN cord-015306-us58wwmp 758 21 was be VBD cord-015306-us58wwmp 758 22 found find VBN cord-015306-us58wwmp 758 23 in in IN cord-015306-us58wwmp 758 24 21 21 CD cord-015306-us58wwmp 758 25 kidneys kidney NNS cord-015306-us58wwmp 758 26 ( ( -LRB- cord-015306-us58wwmp 758 27 45.7 45.7 CD cord-015306-us58wwmp 758 28 % % NN cord-015306-us58wwmp 758 29 ) ) -RRB- cord-015306-us58wwmp 758 30 and and CC cord-015306-us58wwmp 758 31 focally focally RB cord-015306-us58wwmp 758 32 diminished diminished JJ cord-015306-us58wwmp 758 33 activity activity NN cord-015306-us58wwmp 758 34 in in IN cord-015306-us58wwmp 758 35 6 6 CD cord-015306-us58wwmp 758 36 kidneys kidney NNS cord-015306-us58wwmp 758 37 ( ( -LRB- cord-015306-us58wwmp 758 38 13 13 CD cord-015306-us58wwmp 758 39 % % NN cord-015306-us58wwmp 758 40 ) ) -RRB- cord-015306-us58wwmp 758 41 . . . cord-015306-us58wwmp 759 1 Renal renal JJ cord-015306-us58wwmp 759 2 scars scar NNS cord-015306-us58wwmp 759 3 were be VBD cord-015306-us58wwmp 759 4 present present JJ cord-015306-us58wwmp 759 5 in in IN cord-015306-us58wwmp 759 6 7 7 CD cord-015306-us58wwmp 759 7 kidneys kidney NNS cord-015306-us58wwmp 759 8 ( ( -LRB- cord-015306-us58wwmp 759 9 15.2 15.2 CD cord-015306-us58wwmp 759 10 % % NN cord-015306-us58wwmp 759 11 ) ) -RRB- cord-015306-us58wwmp 759 12 . . . cord-015306-us58wwmp 760 1 On on IN cord-015306-us58wwmp 760 2 the the DT cord-015306-us58wwmp 760 3 control control NN cord-015306-us58wwmp 760 4 scintigraphy scintigraphy NN cord-015306-us58wwmp 760 5 20 20 CD cord-015306-us58wwmp 760 6 kidneys kidney NNS cord-015306-us58wwmp 760 7 ( ( -LRB- cord-015306-us58wwmp 760 8 43.5 43.5 CD cord-015306-us58wwmp 760 9 % % NN cord-015306-us58wwmp 760 10 ) ) -RRB- cord-015306-us58wwmp 760 11 had have VBD cord-015306-us58wwmp 760 12 normal normal JJ cord-015306-us58wwmp 760 13 findings finding NNS cord-015306-us58wwmp 760 14 . . . cord-015306-us58wwmp 761 1 Generally generally RB cord-015306-us58wwmp 761 2 diminished diminish VBN cord-015306-us58wwmp 761 3 activity activity NN cord-015306-us58wwmp 761 4 were be VBD cord-015306-us58wwmp 761 5 found find VBN cord-015306-us58wwmp 761 6 in in IN cord-015306-us58wwmp 761 7 6 6 CD cord-015306-us58wwmp 761 8 kidneys kidney NNS cord-015306-us58wwmp 761 9 ( ( -LRB- cord-015306-us58wwmp 761 10 13 13 CD cord-015306-us58wwmp 761 11 % % NN cord-015306-us58wwmp 761 12 ) ) -RRB- cord-015306-us58wwmp 761 13 and and CC cord-015306-us58wwmp 761 14 focal focal JJ cord-015306-us58wwmp 761 15 diminished diminished JJ cord-015306-us58wwmp 761 16 uptake uptake NN cord-015306-us58wwmp 761 17 in in IN cord-015306-us58wwmp 761 18 8 8 CD cord-015306-us58wwmp 761 19 kidneys kidney NNS cord-015306-us58wwmp 761 20 ( ( -LRB- cord-015306-us58wwmp 761 21 17.4 17.4 CD cord-015306-us58wwmp 761 22 % % NN cord-015306-us58wwmp 761 23 ) ) -RRB- cord-015306-us58wwmp 761 24 . . . cord-015306-us58wwmp 762 1 Significantly significantly RB cord-015306-us58wwmp 762 2 higher high JJR cord-015306-us58wwmp 762 3 number number NN cord-015306-us58wwmp 762 4 of of IN cord-015306-us58wwmp 762 5 scars scar NNS cord-015306-us58wwmp 762 6 , , , cord-015306-us58wwmp 762 7 in in IN cord-015306-us58wwmp 762 8 12 12 CD cord-015306-us58wwmp 762 9 kidneys kidney NNS cord-015306-us58wwmp 762 10 ( ( -LRB- cord-015306-us58wwmp 762 11 26.1 26.1 CD cord-015306-us58wwmp 762 12 % % NN cord-015306-us58wwmp 762 13 ) ) -RRB- cord-015306-us58wwmp 762 14 , , , cord-015306-us58wwmp 762 15 despite despite IN cord-015306-us58wwmp 762 16 of of IN cord-015306-us58wwmp 762 17 antibiotic antibiotic JJ cord-015306-us58wwmp 762 18 treatment treatment NN cord-015306-us58wwmp 762 19 were be VBD cord-015306-us58wwmp 762 20 found find VBN cord-015306-us58wwmp 762 21 on on IN cord-015306-us58wwmp 762 22 the the DT cord-015306-us58wwmp 762 23 control control NN cord-015306-us58wwmp 762 24 scintigraphy scintigraphy NN cord-015306-us58wwmp 762 25 ( ( -LRB- cord-015306-us58wwmp 762 26 p p NN cord-015306-us58wwmp 762 27 < < XX cord-015306-us58wwmp 762 28 0.01 0.01 CD cord-015306-us58wwmp 762 29 ) ) -RRB- cord-015306-us58wwmp 762 30 . . . cord-015306-us58wwmp 763 1 Conclusion conclusion NN cord-015306-us58wwmp 763 2 : : : cord-015306-us58wwmp 764 1 DMSA DMSA NNP cord-015306-us58wwmp 764 2 scintigraphy scintigraphy NNP cord-015306-us58wwmp 764 3 demonstrated demonstrate VBD cord-015306-us58wwmp 764 4 that that IN cord-015306-us58wwmp 764 5 the the DT cord-015306-us58wwmp 764 6 infection infection NN cord-015306-us58wwmp 764 7 with with IN cord-015306-us58wwmp 764 8 P-fimbriatedE.coli P-fimbriatedE.coli NNP cord-015306-us58wwmp 764 9 can can MD cord-015306-us58wwmp 764 10 result result VB cord-015306-us58wwmp 764 11 in in IN cord-015306-us58wwmp 764 12 permanent permanent JJ cord-015306-us58wwmp 764 13 renal renal JJ cord-015306-us58wwmp 764 14 damage damage NN cord-015306-us58wwmp 764 15 , , , cord-015306-us58wwmp 764 16 which which WDT cord-015306-us58wwmp 764 17 clearly clearly RB cord-015306-us58wwmp 764 18 points point VBZ cord-015306-us58wwmp 764 19 to to IN cord-015306-us58wwmp 764 20 UTI UTI NNP cord-015306-us58wwmp 764 21 with with IN cord-015306-us58wwmp 764 22 P-fimbriatedE.coli P-fimbriatedE.coli NNP cord-015306-us58wwmp 764 23 as as IN cord-015306-us58wwmp 764 24 a a DT cord-015306-us58wwmp 764 25 risk risk NN cord-015306-us58wwmp 764 26 factor factor NN cord-015306-us58wwmp 764 27 in in IN cord-015306-us58wwmp 764 28 renal renal JJ cord-015306-us58wwmp 764 29 damage damage NN cord-015306-us58wwmp 764 30 . . . cord-015306-us58wwmp 765 1 Our -PRON- PRP$ cord-015306-us58wwmp 765 2 results result NNS cord-015306-us58wwmp 765 3 confirm confirm VBP cord-015306-us58wwmp 765 4 obligatory obligatory JJ cord-015306-us58wwmp 765 5 scintigraphic scintigraphic JJ cord-015306-us58wwmp 765 6 follow follow NN cord-015306-us58wwmp 765 7 - - HYPH cord-015306-us58wwmp 765 8 up up NN cord-015306-us58wwmp 765 9 of of IN cord-015306-us58wwmp 765 10 children child NNS cord-015306-us58wwmp 765 11 with with IN cord-015306-us58wwmp 765 12 positive positive JJ cord-015306-us58wwmp 765 13 P-fimbriatedE.coli p-fimbriatede.coli JJ cord-015306-us58wwmp 765 14 infection infection NN cord-015306-us58wwmp 765 15 . . . cord-015306-us58wwmp 766 1 Objective objective NN cord-015306-us58wwmp 766 2 : : : cord-015306-us58wwmp 767 1 Efficacy efficacy NN cord-015306-us58wwmp 767 2 of of IN cord-015306-us58wwmp 767 3 mannitol mannitol NN cord-015306-us58wwmp 767 4 with with IN cord-015306-us58wwmp 767 5 furosemide furosemide NN cord-015306-us58wwmp 767 6 was be VBD cord-015306-us58wwmp 767 7 compared compare VBN cord-015306-us58wwmp 767 8 with with IN cord-015306-us58wwmp 767 9 that that DT cord-015306-us58wwmp 767 10 of of IN cord-015306-us58wwmp 767 11 albumin albumin NN cord-015306-us58wwmp 767 12 with with IN cord-015306-us58wwmp 767 13 furosemide furosemide NN cord-015306-us58wwmp 767 14 in in IN cord-015306-us58wwmp 767 15 the the DT cord-015306-us58wwmp 767 16 treatment treatment NN cord-015306-us58wwmp 767 17 of of IN cord-015306-us58wwmp 767 18 diuretic diuretic JJ cord-015306-us58wwmp 767 19 resistant resistant JJ cord-015306-us58wwmp 767 20 oedema oedema NN cord-015306-us58wwmp 767 21 in in IN cord-015306-us58wwmp 767 22 childhood childhood NN cord-015306-us58wwmp 767 23 nephrotic nephrotic JJ cord-015306-us58wwmp 767 24 syndrome syndrome NN cord-015306-us58wwmp 767 25 . . . cord-015306-us58wwmp 768 1 Methods method NNS cord-015306-us58wwmp 768 2 : : : cord-015306-us58wwmp 769 1 Forty forty CD cord-015306-us58wwmp 769 2 patients patient NNS cord-015306-us58wwmp 769 3 fulfilling fulfil VBG cord-015306-us58wwmp 769 4 the the DT cord-015306-us58wwmp 769 5 criteria criterion NNS cord-015306-us58wwmp 769 6 for for IN cord-015306-us58wwmp 769 7 " " `` cord-015306-us58wwmp 769 8 resistant resistant JJ cord-015306-us58wwmp 769 9 oedema oedema NN cord-015306-us58wwmp 769 10 " " '' cord-015306-us58wwmp 769 11 in in IN cord-015306-us58wwmp 769 12 nephrotic nephrotic JJ cord-015306-us58wwmp 769 13 syndrome syndrome NN cord-015306-us58wwmp 769 14 cases case NNS cord-015306-us58wwmp 769 15 were be VBD cord-015306-us58wwmp 769 16 enrolled enrol VBN cord-015306-us58wwmp 769 17 in in IN cord-015306-us58wwmp 769 18 this this DT cord-015306-us58wwmp 769 19 descriptive descriptive JJ cord-015306-us58wwmp 769 20 cross cross JJ cord-015306-us58wwmp 769 21 sectional sectional JJ cord-015306-us58wwmp 769 22 study study NN cord-015306-us58wwmp 769 23 . . . cord-015306-us58wwmp 770 1 Resistant resistant JJ cord-015306-us58wwmp 770 2 oedema oedema NN cord-015306-us58wwmp 770 3 was be VBD cord-015306-us58wwmp 770 4 diagnosed diagnose VBN cord-015306-us58wwmp 770 5 based base VBN cord-015306-us58wwmp 770 6 on on IN cord-015306-us58wwmp 770 7 failure failure NN cord-015306-us58wwmp 770 8 to to TO cord-015306-us58wwmp 770 9 achieve achieve VB cord-015306-us58wwmp 770 10 therapeutic therapeutic JJ cord-015306-us58wwmp 770 11 response response NN cord-015306-us58wwmp 770 12 to to IN cord-015306-us58wwmp 770 13 diuretics diuretic NNS cord-015306-us58wwmp 770 14 or or CC cord-015306-us58wwmp 770 15 a a DT cord-015306-us58wwmp 770 16 weight weight NN cord-015306-us58wwmp 770 17 loss loss NN cord-015306-us58wwmp 770 18 of of IN cord-015306-us58wwmp 770 19 < < NNP cord-015306-us58wwmp 770 20 1 1 CD cord-015306-us58wwmp 770 21 % % NN cord-015306-us58wwmp 770 22 body body NN cord-015306-us58wwmp 770 23 weight weight NN cord-015306-us58wwmp 770 24 daily daily RB cord-015306-us58wwmp 770 25 . . . cord-015306-us58wwmp 771 1 All all DT cord-015306-us58wwmp 771 2 nephrotic nephrotic JJ cord-015306-us58wwmp 771 3 syndrome syndrome NN cord-015306-us58wwmp 771 4 patients patient NNS cord-015306-us58wwmp 771 5 with with IN cord-015306-us58wwmp 771 6 severe severe JJ cord-015306-us58wwmp 771 7 oedema oedema NN cord-015306-us58wwmp 771 8 , , , cord-015306-us58wwmp 771 9 age age NN cord-015306-us58wwmp 771 10 1 1 CD cord-015306-us58wwmp 771 11 year year NN cord-015306-us58wwmp 771 12 to to IN cord-015306-us58wwmp 771 13 15 15 CD cord-015306-us58wwmp 771 14 years year NNS cord-015306-us58wwmp 771 15 of of IN cord-015306-us58wwmp 771 16 both both DT cord-015306-us58wwmp 771 17 sexes sex NNS cord-015306-us58wwmp 771 18 were be VBD cord-015306-us58wwmp 771 19 hospitalized hospitalize VBN cord-015306-us58wwmp 771 20 and and CC cord-015306-us58wwmp 771 21 were be VBD cord-015306-us58wwmp 771 22 managed manage VBN cord-015306-us58wwmp 771 23 with with IN cord-015306-us58wwmp 771 24 fluid fluid JJ cord-015306-us58wwmp 771 25 restriction restriction NN cord-015306-us58wwmp 771 26 , , , cord-015306-us58wwmp 771 27 no no DT cord-015306-us58wwmp 771 28 added add VBN cord-015306-us58wwmp 771 29 salt salt NN cord-015306-us58wwmp 771 30 and and CC cord-015306-us58wwmp 771 31 bed bed NN cord-015306-us58wwmp 771 32 rest rest NN cord-015306-us58wwmp 771 33 . . . cord-015306-us58wwmp 772 1 Beside beside IN cord-015306-us58wwmp 772 2 these these DT cord-015306-us58wwmp 772 3 2 2 CD cord-015306-us58wwmp 772 4 mg mg NNP cord-015306-us58wwmp 772 5 / / SYM cord-015306-us58wwmp 772 6 kg kg NNP cord-015306-us58wwmp 772 7 / / SYM cord-015306-us58wwmp 772 8 day day NN cord-015306-us58wwmp 772 9 oral oral JJ cord-015306-us58wwmp 772 10 furosemide furosemide NN cord-015306-us58wwmp 772 11 or or CC cord-015306-us58wwmp 772 12 combination combination NN cord-015306-us58wwmp 772 13 of of IN cord-015306-us58wwmp 772 14 furosemide furosemide NN cord-015306-us58wwmp 772 15 and and CC cord-015306-us58wwmp 772 16 spironolactone spironolactone NN cord-015306-us58wwmp 772 17 , , , cord-015306-us58wwmp 772 18 were be VBD cord-015306-us58wwmp 772 19 given give VBN cord-015306-us58wwmp 772 20 for for IN cord-015306-us58wwmp 772 21 3 3 CD cord-015306-us58wwmp 772 22 days day NNS cord-015306-us58wwmp 772 23 to to TO cord-015306-us58wwmp 772 24 achieve achieve VB cord-015306-us58wwmp 772 25 desired desire VBN cord-015306-us58wwmp 772 26 diuresis diuresis NN cord-015306-us58wwmp 772 27 . . . cord-015306-us58wwmp 773 1 Those those DT cord-015306-us58wwmp 773 2 patients patient NNS cord-015306-us58wwmp 773 3 who who WP cord-015306-us58wwmp 773 4 did do VBD cord-015306-us58wwmp 773 5 not not RB cord-015306-us58wwmp 773 6 get get VB cord-015306-us58wwmp 773 7 response response NN cord-015306-us58wwmp 773 8 were be VBD cord-015306-us58wwmp 773 9 divided divide VBN cord-015306-us58wwmp 773 10 into into IN cord-015306-us58wwmp 773 11 two two CD cord-015306-us58wwmp 773 12 groups group NNS cord-015306-us58wwmp 773 13 ( ( -LRB- cord-015306-us58wwmp 773 14 Group Group NNP cord-015306-us58wwmp 773 15 - - HYPH cord-015306-us58wwmp 773 16 A A NNP cord-015306-us58wwmp 773 17 , , , cord-015306-us58wwmp 773 18 Group Group NNP cord-015306-us58wwmp 773 19 - - HYPH cord-015306-us58wwmp 773 20 B B NNP cord-015306-us58wwmp 773 21 ) ) -RRB- cord-015306-us58wwmp 773 22 in in IN cord-015306-us58wwmp 773 23 consecutive consecutive JJ cord-015306-us58wwmp 773 24 fashion fashion NN cord-015306-us58wwmp 773 25 . . . cord-015306-us58wwmp 774 1 The the DT cord-015306-us58wwmp 774 2 Group Group NNP cord-015306-us58wwmp 774 3 - - : cord-015306-us58wwmp 774 4 A a DT cord-015306-us58wwmp 774 5 study study NN cord-015306-us58wwmp 774 6 population population NN cord-015306-us58wwmp 774 7 , , , cord-015306-us58wwmp 774 8 was be VBD cord-015306-us58wwmp 774 9 with with IN cord-015306-us58wwmp 774 10 intravenous intravenous JJ cord-015306-us58wwmp 774 11 mannitol mannitol NN cord-015306-us58wwmp 774 12 0.5 0.5 CD cord-015306-us58wwmp 774 13 - - HYPH cord-015306-us58wwmp 774 14 1 1 CD cord-015306-us58wwmp 774 15 gm gm NNP cord-015306-us58wwmp 774 16 / / SYM cord-015306-us58wwmp 774 17 kg kg NNP cord-015306-us58wwmp 774 18 / / SYM cord-015306-us58wwmp 774 19 day day NN cord-015306-us58wwmp 774 20 in in IN cord-015306-us58wwmp 774 21 single single JJ cord-015306-us58wwmp 774 22 daily daily JJ cord-015306-us58wwmp 774 23 dose dose NN cord-015306-us58wwmp 774 24 over over IN cord-015306-us58wwmp 774 25 1 1 CD cord-015306-us58wwmp 774 26 - - SYM cord-015306-us58wwmp 774 27 2 2 CD cord-015306-us58wwmp 774 28 hrs hrs NN cord-015306-us58wwmp 774 29 followed follow VBN cord-015306-us58wwmp 774 30 by by IN cord-015306-us58wwmp 774 31 intravenous intravenous JJ cord-015306-us58wwmp 774 32 furosemide furosemide NN cord-015306-us58wwmp 774 33 1 1 CD cord-015306-us58wwmp 774 34 mg mg NNP cord-015306-us58wwmp 774 35 / / SYM cord-015306-us58wwmp 774 36 kg kg NNP cord-015306-us58wwmp 774 37 / / SYM cord-015306-us58wwmp 774 38 day day NN cord-015306-us58wwmp 774 39 for for IN cord-015306-us58wwmp 774 40 5 5 CD cord-015306-us58wwmp 774 41 days day NNS cord-015306-us58wwmp 774 42 . . . cord-015306-us58wwmp 775 1 The the DT cord-015306-us58wwmp 775 2 Group Group NNP cord-015306-us58wwmp 775 3 - - HYPH cord-015306-us58wwmp 775 4 B B NNP cord-015306-us58wwmp 775 5 study study NN cord-015306-us58wwmp 775 6 population population NN cord-015306-us58wwmp 775 7 was be VBD cord-015306-us58wwmp 775 8 with with IN cord-015306-us58wwmp 775 9 intravenous intravenous JJ cord-015306-us58wwmp 775 10 albumin albumin NN cord-015306-us58wwmp 775 11 , , , cord-015306-us58wwmp 775 12 0.5 0.5 CD cord-015306-us58wwmp 775 13 -1 -1 NN cord-015306-us58wwmp 775 14 gm/ gm/ NNP cord-015306-us58wwmp 775 15 kg kg NNP cord-015306-us58wwmp 775 16 /day /day NFP cord-015306-us58wwmp 775 17 in in IN cord-015306-us58wwmp 775 18 single single JJ cord-015306-us58wwmp 775 19 daily daily JJ cord-015306-us58wwmp 775 20 dose dose NN cord-015306-us58wwmp 775 21 over over IN cord-015306-us58wwmp 775 22 1 1 CD cord-015306-us58wwmp 775 23 - - SYM cord-015306-us58wwmp 775 24 2 2 CD cord-015306-us58wwmp 775 25 hrs hrs NN cord-015306-us58wwmp 775 26 followed follow VBN cord-015306-us58wwmp 775 27 by by IN cord-015306-us58wwmp 775 28 intravenous intravenous JJ cord-015306-us58wwmp 775 29 furosemide furosemide NN cord-015306-us58wwmp 775 30 1 1 CD cord-015306-us58wwmp 776 1 mg mg NNP cord-015306-us58wwmp 776 2 / / SYM cord-015306-us58wwmp 776 3 kg kg NNP cord-015306-us58wwmp 776 4 / / SYM cord-015306-us58wwmp 776 5 day day NN cord-015306-us58wwmp 776 6 in in IN cord-015306-us58wwmp 776 7 every every DT cord-015306-us58wwmp 776 8 alternate alternate JJ cord-015306-us58wwmp 776 9 day day NN cord-015306-us58wwmp 776 10 , , , cord-015306-us58wwmp 776 11 total total JJ cord-015306-us58wwmp 776 12 3 3 CD cord-015306-us58wwmp 776 13 doses dose NNS cord-015306-us58wwmp 776 14 . . . cord-015306-us58wwmp 777 1 Conclusion conclusion NN cord-015306-us58wwmp 777 2 : : : cord-015306-us58wwmp 778 1 This this DT cord-015306-us58wwmp 778 2 boy boy NN cord-015306-us58wwmp 778 3 presented present VBD cord-015306-us58wwmp 778 4 with with IN cord-015306-us58wwmp 778 5 Rhabdomyolysis rhabdomyolysis NN cord-015306-us58wwmp 778 6 , , , cord-015306-us58wwmp 778 7 myohemoglobinuria myohemoglobinuria NN cord-015306-us58wwmp 778 8 and and CC cord-015306-us58wwmp 778 9 ARF ARF NNP cord-015306-us58wwmp 778 10 . . . cord-015306-us58wwmp 779 1 ( ( -LRB- cord-015306-us58wwmp 779 2 Similar Similar NNP cord-015306-us58wwmp 779 3 Pr Pr NNP cord-015306-us58wwmp 779 4 Similar Similar NNP cord-015306-us58wwmp 779 5 Presentation Presentation NNP cord-015306-us58wwmp 779 6 can can MD cord-015306-us58wwmp 779 7 be be VB cord-015306-us58wwmp 779 8 rarely rarely RB cord-015306-us58wwmp 779 9 seen see VBN cord-015306-us58wwmp 779 10 in in IN cord-015306-us58wwmp 779 11 human human JJ cord-015306-us58wwmp 779 12 being being NN cord-015306-us58wwmp 779 13 , , , cord-015306-us58wwmp 779 14 but but CC cord-015306-us58wwmp 779 15 often often RB cord-015306-us58wwmp 779 16 seen see VBN cord-015306-us58wwmp 779 17 in in IN cord-015306-us58wwmp 779 18 dogs dog NNS cord-015306-us58wwmp 779 19 ) ) -RRB- cord-015306-us58wwmp 779 20 . . . cord-015306-us58wwmp 780 1 Blood blood NN cord-015306-us58wwmp 780 2 exchange exchange NN cord-015306-us58wwmp 780 3 transfusion transfusion NN cord-015306-us58wwmp 780 4 in in IN cord-015306-us58wwmp 780 5 time time NN cord-015306-us58wwmp 780 6 must must MD cord-015306-us58wwmp 780 7 be be VB cord-015306-us58wwmp 780 8 necessary necessary JJ cord-015306-us58wwmp 780 9 for for IN cord-015306-us58wwmp 780 10 preventing prevent VBG cord-015306-us58wwmp 780 11 " " `` cord-015306-us58wwmp 780 12 water water NN cord-015306-us58wwmp 780 13 fall fall NN cord-015306-us58wwmp 780 14 effect effect NN cord-015306-us58wwmp 780 15 " " '' cord-015306-us58wwmp 780 16 established establish VBN cord-015306-us58wwmp 780 17 , , , cord-015306-us58wwmp 780 18 for for IN cord-015306-us58wwmp 780 19 it -PRON- PRP cord-015306-us58wwmp 780 20 can can MD cord-015306-us58wwmp 780 21 eliminate eliminate VB cord-015306-us58wwmp 780 22 inflammatory inflammatory JJ cord-015306-us58wwmp 780 23 factor factor NN cord-015306-us58wwmp 780 24 and and CC cord-015306-us58wwmp 780 25 toxic toxic JJ cord-015306-us58wwmp 780 26 products product NNS cord-015306-us58wwmp 780 27 such such JJ cord-015306-us58wwmp 780 28 as as IN cord-015306-us58wwmp 780 29 BUN BUN NNP cord-015306-us58wwmp 780 30 , , , cord-015306-us58wwmp 780 31 Ccr Ccr NNP cord-015306-us58wwmp 780 32 , , , cord-015306-us58wwmp 780 33 and and CC cord-015306-us58wwmp 780 34 creatinasein creatinasein NNP cord-015306-us58wwmp 780 35 blood blood NN cord-015306-us58wwmp 780 36 effectively effectively RB cord-015306-us58wwmp 780 37 . . . cord-015306-us58wwmp 781 1 Blood blood NN cord-015306-us58wwmp 781 2 tranfusion tranfusion NN cord-015306-us58wwmp 781 3 in in IN cord-015306-us58wwmp 781 4 combination combination NN cord-015306-us58wwmp 781 5 with with IN cord-015306-us58wwmp 781 6 Azithromycin Azithromycin NNP cord-015306-us58wwmp 781 7 and and CC cord-015306-us58wwmp 781 8 Clindamycin Clindamycin NNP cord-015306-us58wwmp 781 9 must must MD cord-015306-us58wwmp 781 10 be be VB cord-015306-us58wwmp 781 11 a a DT cord-015306-us58wwmp 781 12 good good JJ cord-015306-us58wwmp 781 13 choice choice NN cord-015306-us58wwmp 781 14 replace replace VB cord-015306-us58wwmp 781 15 the the DT cord-015306-us58wwmp 781 16 " " `` cord-015306-us58wwmp 781 17 Babesia Babesia NNP cord-015306-us58wwmp 781 18 - - HYPH cord-015306-us58wwmp 781 19 infected infect VBN cord-015306-us58wwmp 781 20 " " `` cord-015306-us58wwmp 781 21 RBC RBC NNP cord-015306-us58wwmp 781 22 and and CC cord-015306-us58wwmp 781 23 eliminate eliminate VB cord-015306-us58wwmp 781 24 pathogens pathogen NNS cord-015306-us58wwmp 781 25 in in IN cord-015306-us58wwmp 781 26 blood blood NN cord-015306-us58wwmp 781 27 . . . cord-015306-us58wwmp 782 1 Beta-2-microglobulinuria Beta-2-microglobulinuria NNP cord-015306-us58wwmp 782 2 in in IN cord-015306-us58wwmp 782 3 Human human JJ cord-015306-us58wwmp 782 4 immunodeficiency immunodeficiency NN cord-015306-us58wwmp 782 5 virus virus NN cord-015306-us58wwmp 782 6 infected infect VBD cord-015306-us58wwmp 782 7 children child NNS cord-015306-us58wwmp 782 8 Objective objective VBP cord-015306-us58wwmp 782 9 : : : cord-015306-us58wwmp 782 10 To to TO cord-015306-us58wwmp 782 11 determine determine VB cord-015306-us58wwmp 782 12 whether whether IN cord-015306-us58wwmp 782 13 HIV HIV NNP cord-015306-us58wwmp 782 14 infection infection NN cord-015306-us58wwmp 782 15 in in IN cord-015306-us58wwmp 782 16 children child NNS cord-015306-us58wwmp 782 17 is be VBZ cord-015306-us58wwmp 782 18 associated associate VBN cord-015306-us58wwmp 782 19 with with IN cord-015306-us58wwmp 782 20 increased increase VBN cord-015306-us58wwmp 782 21 urinary urinary JJ cord-015306-us58wwmp 782 22 excretion excretion NN cord-015306-us58wwmp 782 23 of of IN cord-015306-us58wwmp 782 24 β2-microglobulin β2-microglobulin NNP cord-015306-us58wwmp 782 25 , , , cord-015306-us58wwmp 782 26 which which WDT cord-015306-us58wwmp 782 27 is be VBZ cord-015306-us58wwmp 782 28 a a DT cord-015306-us58wwmp 782 29 marker marker NN cord-015306-us58wwmp 782 30 of of IN cord-015306-us58wwmp 782 31 tubular tubular JJ cord-015306-us58wwmp 782 32 defect defect NN cord-015306-us58wwmp 782 33 . . . cord-015306-us58wwmp 783 1 Methods method NNS cord-015306-us58wwmp 783 2 : : : cord-015306-us58wwmp 783 3 A a DT cord-015306-us58wwmp 783 4 prospective prospective JJ cord-015306-us58wwmp 783 5 observational observational JJ cord-015306-us58wwmp 783 6 study study NN cord-015306-us58wwmp 783 7 was be VBD cord-015306-us58wwmp 783 8 done do VBN cord-015306-us58wwmp 783 9 of of IN cord-015306-us58wwmp 783 10 HIV HIV NNP cord-015306-us58wwmp 783 11 infected infect VBN cord-015306-us58wwmp 783 12 children child NNS cord-015306-us58wwmp 783 13 attending attend VBG cord-015306-us58wwmp 783 14 outpatient outpatient NN cord-015306-us58wwmp 783 15 immunology immunology NN cord-015306-us58wwmp 783 16 clinics clinic NNS cord-015306-us58wwmp 783 17 to to TO cord-015306-us58wwmp 783 18 investigate investigate VB cord-015306-us58wwmp 783 19 urinary urinary JJ cord-015306-us58wwmp 783 20 β2-microglobulin β2-microglobulin NN cord-015306-us58wwmp 783 21 excretion excretion NN cord-015306-us58wwmp 783 22 by by IN cord-015306-us58wwmp 783 23 measuring measure VBG cord-015306-us58wwmp 783 24 urine urine NN cord-015306-us58wwmp 783 25 β2-microglobulin β2-microglobulin NN cord-015306-us58wwmp 783 26 to to IN cord-015306-us58wwmp 783 27 creatinine creatinine NN cord-015306-us58wwmp 783 28 ratio ratio NN cord-015306-us58wwmp 783 29 . . . cord-015306-us58wwmp 784 1 In in IN cord-015306-us58wwmp 784 2 addition addition NN cord-015306-us58wwmp 784 3 serum serum NN cord-015306-us58wwmp 784 4 sodium sodium NN cord-015306-us58wwmp 784 5 , , , cord-015306-us58wwmp 784 6 potassium potassium NN cord-015306-us58wwmp 784 7 , , , cord-015306-us58wwmp 784 8 urea urea NN cord-015306-us58wwmp 784 9 , , , cord-015306-us58wwmp 784 10 bicarbonate bicarbonate NN cord-015306-us58wwmp 784 11 and and CC cord-015306-us58wwmp 784 12 creatinine creatinine NN cord-015306-us58wwmp 784 13 levels level NNS cord-015306-us58wwmp 784 14 were be VBD cord-015306-us58wwmp 784 15 documented document VBN cord-015306-us58wwmp 784 16 and and CC cord-015306-us58wwmp 784 17 urine urine NN cord-015306-us58wwmp 784 18 dipstick dipstick NN cord-015306-us58wwmp 784 19 test test NN cord-015306-us58wwmp 784 20 was be VBD cord-015306-us58wwmp 784 21 done do VBN cord-015306-us58wwmp 784 22 to to TO cord-015306-us58wwmp 784 23 quantify quantify VB cord-015306-us58wwmp 784 24 proteinuria proteinuria NN cord-015306-us58wwmp 784 25 . . . cord-015306-us58wwmp 785 1 Results result NNS cord-015306-us58wwmp 785 2 : : : cord-015306-us58wwmp 786 1 Thirteen thirteen CD cord-015306-us58wwmp 786 2 ( ( -LRB- cord-015306-us58wwmp 786 3 13 13 CD cord-015306-us58wwmp 786 4 ) ) -RRB- cord-015306-us58wwmp 786 5 children child NNS cord-015306-us58wwmp 786 6 aged age VBN cord-015306-us58wwmp 786 7 2 2 CD cord-015306-us58wwmp 786 8 months month NNS cord-015306-us58wwmp 786 9 to to IN cord-015306-us58wwmp 786 10 49 49 CD cord-015306-us58wwmp 786 11 months month NNS cord-015306-us58wwmp 786 12 ( ( -LRB- cord-015306-us58wwmp 786 13 mean mean VBP cord-015306-us58wwmp 786 14 20+/-4 20+/-4 CD cord-015306-us58wwmp 786 15 months month NNS cord-015306-us58wwmp 786 16 ) ) -RRB- cord-015306-us58wwmp 786 17 were be VBD cord-015306-us58wwmp 786 18 enrolled enrol VBN cord-015306-us58wwmp 786 19 . . . cord-015306-us58wwmp 787 1 All all DT cord-015306-us58wwmp 787 2 children child NNS cord-015306-us58wwmp 787 3 had have VBD cord-015306-us58wwmp 787 4 normal normal JJ cord-015306-us58wwmp 787 5 estimated estimate VBN cord-015306-us58wwmp 787 6 glomerular glomerular JJ cord-015306-us58wwmp 787 7 filtration filtration NN cord-015306-us58wwmp 787 8 rate rate NN cord-015306-us58wwmp 787 9 . . . cord-015306-us58wwmp 788 1 Eleven eleven CD cord-015306-us58wwmp 788 2 children child NNS cord-015306-us58wwmp 788 3 were be VBD cord-015306-us58wwmp 788 4 on on IN cord-015306-us58wwmp 788 5 different different JJ cord-015306-us58wwmp 788 6 HAART HAART NNP cord-015306-us58wwmp 788 7 regimes regime NNS cord-015306-us58wwmp 788 8 ( ( -LRB- cord-015306-us58wwmp 788 9 see see VB cord-015306-us58wwmp 788 10 table table NN cord-015306-us58wwmp 788 11 1 1 CD cord-015306-us58wwmp 788 12 ) ) -RRB- cord-015306-us58wwmp 788 13 , , , cord-015306-us58wwmp 788 14 one one CD cord-015306-us58wwmp 788 15 was be VBD cord-015306-us58wwmp 788 16 receiving receive VBG cord-015306-us58wwmp 788 17 nevirapine nevirapine JJ cord-015306-us58wwmp 788 18 prophylaxis prophylaxis NN cord-015306-us58wwmp 788 19 and and CC cord-015306-us58wwmp 788 20 one one CD cord-015306-us58wwmp 788 21 was be VBD cord-015306-us58wwmp 788 22 not not RB cord-015306-us58wwmp 788 23 on on IN cord-015306-us58wwmp 788 24 any any DT cord-015306-us58wwmp 788 25 treatment treatment NN cord-015306-us58wwmp 788 26 . . . cord-015306-us58wwmp 789 1 The the DT cord-015306-us58wwmp 789 2 duration duration NN cord-015306-us58wwmp 789 3 of of IN cord-015306-us58wwmp 789 4 HAART HAART NNP cord-015306-us58wwmp 789 5 use use NN cord-015306-us58wwmp 789 6 was be VBD cord-015306-us58wwmp 789 7 1 1 CD cord-015306-us58wwmp 789 8 - - SYM cord-015306-us58wwmp 789 9 16 16 CD cord-015306-us58wwmp 789 10 months month NNS cord-015306-us58wwmp 789 11 ( ( -LRB- cord-015306-us58wwmp 789 12 mean mean UH cord-015306-us58wwmp 789 13 of of IN cord-015306-us58wwmp 789 14 8+/-2 8+/-2 CD cord-015306-us58wwmp 789 15 months month NNS cord-015306-us58wwmp 789 16 ) ) -RRB- cord-015306-us58wwmp 789 17 . . . cord-015306-us58wwmp 790 1 Seven seven CD cord-015306-us58wwmp 790 2 ( ( -LRB- cord-015306-us58wwmp 790 3 7 7 CD cord-015306-us58wwmp 790 4 ) ) -RRB- cord-015306-us58wwmp 790 5 children child NNS cord-015306-us58wwmp 790 6 were be VBD cord-015306-us58wwmp 790 7 on on IN cord-015306-us58wwmp 790 8 cotrimoxazole cotrimoxazole NN cord-015306-us58wwmp 790 9 for for IN cord-015306-us58wwmp 790 10 Pneumocystis Pneumocystis NNP cord-015306-us58wwmp 790 11 Jiroveci Jiroveci NNP cord-015306-us58wwmp 790 12 prophylaxis prophylaxis NN cord-015306-us58wwmp 790 13 and and CC cord-015306-us58wwmp 790 14 4 4 CD cord-015306-us58wwmp 790 15 on on IN cord-015306-us58wwmp 790 16 anti anti JJ cord-015306-us58wwmp 790 17 - - JJ cord-015306-us58wwmp 790 18 tuberculosis tuberculosis JJ cord-015306-us58wwmp 790 19 drugs drug NNS cord-015306-us58wwmp 790 20 , , , cord-015306-us58wwmp 790 21 namely namely RB cord-015306-us58wwmp 790 22 rifampicin rifampicin NNP cord-015306-us58wwmp 790 23 , , , cord-015306-us58wwmp 790 24 ethambutol ethambutol NNP cord-015306-us58wwmp 790 25 , , , cord-015306-us58wwmp 790 26 isoniazid isoniazid NN cord-015306-us58wwmp 790 27 and and CC cord-015306-us58wwmp 790 28 pyrazinamide pyrazinamide NN cord-015306-us58wwmp 790 29 . . . cord-015306-us58wwmp 791 1 None none NN cord-015306-us58wwmp 791 2 received receive VBD cord-015306-us58wwmp 791 3 any any DT cord-015306-us58wwmp 791 4 nephrotoxic nephrotoxic NNP cord-015306-us58wwmp 791 5 drugs drug NNS cord-015306-us58wwmp 791 6 . . . cord-015306-us58wwmp 792 1 The the DT cord-015306-us58wwmp 792 2 HIV HIV NNP cord-015306-us58wwmp 792 3 viral viral JJ cord-015306-us58wwmp 792 4 load load NN cord-015306-us58wwmp 792 5 was be VBD cord-015306-us58wwmp 792 6 > > NFP cord-015306-us58wwmp 792 7 1000 1000 CD cord-015306-us58wwmp 792 8 copies copy NNS cord-015306-us58wwmp 792 9 / / SYM cord-015306-us58wwmp 792 10 ml ml NNS cord-015306-us58wwmp 792 11 in in IN cord-015306-us58wwmp 792 12 8 8 CD cord-015306-us58wwmp 792 13 children child NNS cord-015306-us58wwmp 792 14 and and CC cord-015306-us58wwmp 792 15 < < XX cord-015306-us58wwmp 792 16 1000 1000 CD cord-015306-us58wwmp 792 17 copies copy NNS cord-015306-us58wwmp 793 1 /ml /ml NFP cord-015306-us58wwmp 793 2 in in IN cord-015306-us58wwmp 793 3 5 5 CD cord-015306-us58wwmp 793 4 children child NNS cord-015306-us58wwmp 793 5 . . . cord-015306-us58wwmp 794 1 Of of IN cord-015306-us58wwmp 794 2 13 13 CD cord-015306-us58wwmp 794 3 HIV HIV NNP cord-015306-us58wwmp 794 4 - - HYPH cord-015306-us58wwmp 794 5 infected infect VBN cord-015306-us58wwmp 794 6 children child NNS cord-015306-us58wwmp 794 7 , , , cord-015306-us58wwmp 794 8 4(31 4(31 CD cord-015306-us58wwmp 794 9 % % NN cord-015306-us58wwmp 794 10 ) ) -RRB- cord-015306-us58wwmp 794 11 had have VBD cord-015306-us58wwmp 794 12 no no DT cord-015306-us58wwmp 794 13 abnormal abnormal JJ cord-015306-us58wwmp 794 14 urine urine NN cord-015306-us58wwmp 794 15 protein protein NN cord-015306-us58wwmp 794 16 excretion excretion NN cord-015306-us58wwmp 794 17 and and CC cord-015306-us58wwmp 794 18 nine nine CD cord-015306-us58wwmp 794 19 ( ( -LRB- cord-015306-us58wwmp 794 20 69 69 CD cord-015306-us58wwmp 794 21 % % NN cord-015306-us58wwmp 794 22 ) ) -RRB- cord-015306-us58wwmp 794 23 had have VBD cord-015306-us58wwmp 794 24 elevated elevate VBN cord-015306-us58wwmp 794 25 urinary urinary JJ cord-015306-us58wwmp 794 26 levels level NNS cord-015306-us58wwmp 794 27 of of IN cord-015306-us58wwmp 794 28 β2-microglobulin β2-microglobulin NNS cord-015306-us58wwmp 794 29 . . . cord-015306-us58wwmp 795 1 Of of IN cord-015306-us58wwmp 795 2 note note VB cord-015306-us58wwmp 795 3 only only RB cord-015306-us58wwmp 795 4 2 2 CD cord-015306-us58wwmp 795 5 ( ( -LRB- cord-015306-us58wwmp 795 6 22 22 CD cord-015306-us58wwmp 795 7 % % NN cord-015306-us58wwmp 795 8 ) ) -RRB- cord-015306-us58wwmp 795 9 of of IN cord-015306-us58wwmp 795 10 the the DT cord-015306-us58wwmp 795 11 9 9 CD cord-015306-us58wwmp 795 12 children child NNS cord-015306-us58wwmp 795 13 with with IN cord-015306-us58wwmp 795 14 β2-microglobulinuria β2-microglobulinuria NNS cord-015306-us58wwmp 795 15 had have VBD cord-015306-us58wwmp 795 16 associated associate VBN cord-015306-us58wwmp 795 17 proteinuria proteinuria NN cord-015306-us58wwmp 795 18 . . . cord-015306-us58wwmp 796 1 Ten ten CD cord-015306-us58wwmp 796 2 children child NNS cord-015306-us58wwmp 796 3 ( ( -LRB- cord-015306-us58wwmp 796 4 76 76 CD cord-015306-us58wwmp 796 5 % % NN cord-015306-us58wwmp 796 6 ) ) -RRB- cord-015306-us58wwmp 796 7 had have VBD cord-015306-us58wwmp 796 8 metabolic metabolic JJ cord-015306-us58wwmp 796 9 acidosis acidosis NN cord-015306-us58wwmp 796 10 with with IN cord-015306-us58wwmp 796 11 the the DT cord-015306-us58wwmp 796 12 mean mean JJ cord-015306-us58wwmp 796 13 serum serum NN cord-015306-us58wwmp 796 14 bicarbonate bicarbonate NN cord-015306-us58wwmp 796 15 ( ( -LRB- cord-015306-us58wwmp 796 16 CO CO NNP cord-015306-us58wwmp 796 17 2 2 CD cord-015306-us58wwmp 796 18 ) ) -RRB- cord-015306-us58wwmp 796 19 level level NN cord-015306-us58wwmp 796 20 of of IN cord-015306-us58wwmp 796 21 16.9 16.9 CD cord-015306-us58wwmp 796 22 mmol mmol NNP cord-015306-us58wwmp 796 23 / / SYM cord-015306-us58wwmp 796 24 l l NN cord-015306-us58wwmp 796 25 ( ( -LRB- cord-015306-us58wwmp 796 26 range range NNP cord-015306-us58wwmp 796 27 10 10 CD cord-015306-us58wwmp 796 28 - - SYM cord-015306-us58wwmp 796 29 20 20 CD cord-015306-us58wwmp 796 30 mmol mmol JJ cord-015306-us58wwmp 796 31 / / SYM cord-015306-us58wwmp 796 32 l l NN cord-015306-us58wwmp 796 33 ) ) -RRB- cord-015306-us58wwmp 796 34 . . . cord-015306-us58wwmp 797 1 Conclusion conclusion NN cord-015306-us58wwmp 797 2 : : : cord-015306-us58wwmp 798 1 Proteinuria Proteinuria NNP cord-015306-us58wwmp 798 2 is be VBZ cord-015306-us58wwmp 798 3 believed believe VBN cord-015306-us58wwmp 798 4 to to TO cord-015306-us58wwmp 798 5 be be VB cord-015306-us58wwmp 798 6 the the DT cord-015306-us58wwmp 798 7 earliest early JJS cord-015306-us58wwmp 798 8 finding finding NN cord-015306-us58wwmp 798 9 for for IN cord-015306-us58wwmp 798 10 the the DT cord-015306-us58wwmp 798 11 diagnosis diagnosis NN cord-015306-us58wwmp 798 12 of of IN cord-015306-us58wwmp 798 13 HIV HIV NNP cord-015306-us58wwmp 798 14 associated associate VBD cord-015306-us58wwmp 798 15 renal renal JJ cord-015306-us58wwmp 798 16 diseases disease NNS cord-015306-us58wwmp 798 17 . . . cord-015306-us58wwmp 799 1 In in IN cord-015306-us58wwmp 799 2 our -PRON- PRP$ cord-015306-us58wwmp 799 3 study study NN cord-015306-us58wwmp 799 4 β2microglobulinuria β2microglobulinuria NNS cord-015306-us58wwmp 799 5 and and CC cord-015306-us58wwmp 799 6 metabolic metabolic JJ cord-015306-us58wwmp 799 7 acidosis acidosis NN cord-015306-us58wwmp 799 8 were be VBD cord-015306-us58wwmp 799 9 the the DT cord-015306-us58wwmp 799 10 prominent prominent JJ cord-015306-us58wwmp 799 11 findings finding NNS cord-015306-us58wwmp 799 12 suggesting suggest VBG cord-015306-us58wwmp 799 13 that that IN cord-015306-us58wwmp 799 14 HIV HIV NNP cord-015306-us58wwmp 799 15 induces induce VBZ cord-015306-us58wwmp 799 16 tubular tubular JJ cord-015306-us58wwmp 799 17 dysfunction dysfunction NN cord-015306-us58wwmp 799 18 in in IN cord-015306-us58wwmp 799 19 children child NNS cord-015306-us58wwmp 799 20 without without IN cord-015306-us58wwmp 799 21 clinical clinical JJ cord-015306-us58wwmp 799 22 evidence evidence NN cord-015306-us58wwmp 799 23 of of IN cord-015306-us58wwmp 799 24 renal renal JJ cord-015306-us58wwmp 799 25 disease disease NN cord-015306-us58wwmp 799 26 . . . cord-015306-us58wwmp 800 1 Objective objective NN cord-015306-us58wwmp 800 2 : : : cord-015306-us58wwmp 801 1 Acute acute JJ cord-015306-us58wwmp 801 2 kidney kidney NN cord-015306-us58wwmp 801 3 injury injury NN cord-015306-us58wwmp 801 4 ( ( -LRB- cord-015306-us58wwmp 801 5 AKI AKI NNP cord-015306-us58wwmp 801 6 ) ) -RRB- cord-015306-us58wwmp 801 7 is be VBZ cord-015306-us58wwmp 801 8 an an DT cord-015306-us58wwmp 801 9 important important JJ cord-015306-us58wwmp 801 10 cause cause NN cord-015306-us58wwmp 801 11 of of IN cord-015306-us58wwmp 801 12 mortality mortality NN cord-015306-us58wwmp 801 13 in in IN cord-015306-us58wwmp 801 14 sub sub NNP cord-015306-us58wwmp 801 15 Saharan Saharan NNP cord-015306-us58wwmp 801 16 Africa Africa NNP cord-015306-us58wwmp 801 17 because because IN cord-015306-us58wwmp 801 18 access access NN cord-015306-us58wwmp 801 19 to to IN cord-015306-us58wwmp 801 20 renal renal JJ cord-015306-us58wwmp 801 21 replacement replacement NN cord-015306-us58wwmp 801 22 therapy therapy NN cord-015306-us58wwmp 801 23 is be VBZ cord-015306-us58wwmp 801 24 limited limit VBN cord-015306-us58wwmp 801 25 . . . cord-015306-us58wwmp 802 1 There there EX cord-015306-us58wwmp 802 2 are be VBP cord-015306-us58wwmp 802 3 few few JJ cord-015306-us58wwmp 802 4 reports report NNS cord-015306-us58wwmp 802 5 on on IN cord-015306-us58wwmp 802 6 haemodialysis haemodialysis NNP cord-015306-us58wwmp 802 7 in in IN cord-015306-us58wwmp 802 8 childhood childhood NN cord-015306-us58wwmp 802 9 AKI AKI NNP cord-015306-us58wwmp 802 10 in in IN cord-015306-us58wwmp 802 11 the the DT cord-015306-us58wwmp 802 12 sub sub NN cord-015306-us58wwmp 802 13 region region NN cord-015306-us58wwmp 802 14 . . . cord-015306-us58wwmp 803 1 We -PRON- PRP cord-015306-us58wwmp 803 2 therefore therefore RB cord-015306-us58wwmp 803 3 performed perform VBD cord-015306-us58wwmp 803 4 a a DT cord-015306-us58wwmp 803 5 preliminary preliminary JJ cord-015306-us58wwmp 803 6 review review NN cord-015306-us58wwmp 803 7 of of IN cord-015306-us58wwmp 803 8 data datum NNS cord-015306-us58wwmp 803 9 on on IN cord-015306-us58wwmp 803 10 children child NNS cord-015306-us58wwmp 803 11 who who WP cord-015306-us58wwmp 803 12 received receive VBD cord-015306-us58wwmp 803 13 intermittent intermittent JJ cord-015306-us58wwmp 803 14 haemodialysis haemodialysis NN cord-015306-us58wwmp 803 15 for for IN cord-015306-us58wwmp 803 16 AKI AKI NNP cord-015306-us58wwmp 803 17 in in IN cord-015306-us58wwmp 803 18 our -PRON- PRP$ cord-015306-us58wwmp 803 19 centre centre NN cord-015306-us58wwmp 803 20 . . . cord-015306-us58wwmp 804 1 Method method NN cord-015306-us58wwmp 804 2 : : : cord-015306-us58wwmp 805 1 A a DT cord-015306-us58wwmp 805 2 retrospective retrospective JJ cord-015306-us58wwmp 805 3 review review NN cord-015306-us58wwmp 805 4 of of IN cord-015306-us58wwmp 805 5 case case NN cord-015306-us58wwmp 805 6 records record NNS cord-015306-us58wwmp 805 7 and and CC cord-015306-us58wwmp 805 8 haemodialysis haemodialysis NNP cord-015306-us58wwmp 805 9 registers register NNS cord-015306-us58wwmp 805 10 of of IN cord-015306-us58wwmp 805 11 children child NNS cord-015306-us58wwmp 805 12 in in IN cord-015306-us58wwmp 805 13 AKI AKI NNP cord-015306-us58wwmp 805 14 who who WP cord-015306-us58wwmp 805 15 received receive VBD cord-015306-us58wwmp 805 16 haemodialysis haemodialysis NNP cord-015306-us58wwmp 805 17 in in IN cord-015306-us58wwmp 805 18 our -PRON- PRP$ cord-015306-us58wwmp 805 19 centre centre NN cord-015306-us58wwmp 805 20 from from IN cord-015306-us58wwmp 805 21 January January NNP cord-015306-us58wwmp 805 22 2006 2006 CD cord-015306-us58wwmp 805 23 to to IN cord-015306-us58wwmp 805 24 December December NNP cord-015306-us58wwmp 805 25 2012 2012 CD cord-015306-us58wwmp 805 26 . . . cord-015306-us58wwmp 806 1 Results result NNS cord-015306-us58wwmp 806 2 : : : cord-015306-us58wwmp 807 1 62 62 CD cord-015306-us58wwmp 807 2 children child NNS cord-015306-us58wwmp 807 3 , , , cord-015306-us58wwmp 807 4 including include VBG cord-015306-us58wwmp 807 5 a a DT cord-015306-us58wwmp 807 6 child child NN cord-015306-us58wwmp 807 7 aged age VBN cord-015306-us58wwmp 807 8 3years 3years NN cord-015306-us58wwmp 807 9 , , , cord-015306-us58wwmp 807 10 received receive VBD cord-015306-us58wwmp 807 11 haemodialysis haemodialysis NNP cord-015306-us58wwmp 807 12 for for IN cord-015306-us58wwmp 807 13 AKI AKI NNP cord-015306-us58wwmp 807 14 over over IN cord-015306-us58wwmp 807 15 the the DT cord-015306-us58wwmp 807 16 period period NN cord-015306-us58wwmp 807 17 but but CC cord-015306-us58wwmp 807 18 full full JJ cord-015306-us58wwmp 807 19 details detail NNS cord-015306-us58wwmp 807 20 were be VBD cord-015306-us58wwmp 807 21 available available JJ cord-015306-us58wwmp 807 22 for for IN cord-015306-us58wwmp 807 23 23 23 CD cord-015306-us58wwmp 807 24 children child NNS cord-015306-us58wwmp 807 25 and and CC cord-015306-us58wwmp 807 26 were be VBD cord-015306-us58wwmp 807 27 further further RB cord-015306-us58wwmp 807 28 reviewed review VBN cord-015306-us58wwmp 807 29 for for IN cord-015306-us58wwmp 807 30 this this DT cord-015306-us58wwmp 807 31 study study NN cord-015306-us58wwmp 807 32 . . . cord-015306-us58wwmp 808 1 There there EX cord-015306-us58wwmp 808 2 were be VBD cord-015306-us58wwmp 808 3 13 13 CD cord-015306-us58wwmp 808 4 males male NNS cord-015306-us58wwmp 808 5 ( ( -LRB- cord-015306-us58wwmp 808 6 56.5 56.5 CD cord-015306-us58wwmp 808 7 % % NN cord-015306-us58wwmp 808 8 ) ) -RRB- cord-015306-us58wwmp 808 9 . . . cord-015306-us58wwmp 809 1 The the DT cord-015306-us58wwmp 809 2 children child NNS cord-015306-us58wwmp 809 3 were be VBD cord-015306-us58wwmp 809 4 aged age VBN cord-015306-us58wwmp 809 5 5 5 CD cord-015306-us58wwmp 809 6 - - SYM cord-015306-us58wwmp 809 7 13 13 CD cord-015306-us58wwmp 809 8 ( ( -LRB- cord-015306-us58wwmp 809 9 8.4+/-2.4 8.4+/-2.4 CD cord-015306-us58wwmp 809 10 ) ) -RRB- cord-015306-us58wwmp 809 11 years year NNS cord-015306-us58wwmp 809 12 . . . cord-015306-us58wwmp 810 1 The the DT cord-015306-us58wwmp 810 2 primary primary JJ cord-015306-us58wwmp 810 3 aetiology aetiology NN cord-015306-us58wwmp 810 4 of of IN cord-015306-us58wwmp 810 5 AKI AKI NNP cord-015306-us58wwmp 810 6 was be VBD cord-015306-us58wwmp 810 7 related relate VBN cord-015306-us58wwmp 810 8 to to IN cord-015306-us58wwmp 810 9 intravascular intravascular JJ cord-015306-us58wwmp 810 10 haemolysis haemolysis NN cord-015306-us58wwmp 810 11 ( ( -LRB- cord-015306-us58wwmp 810 12 IVH IVH NNP cord-015306-us58wwmp 810 13 ) ) -RRB- cord-015306-us58wwmp 810 14 with with IN cord-015306-us58wwmp 810 15 massive massive JJ cord-015306-us58wwmp 810 16 haemoglobinuria haemoglobinuria NNP cord-015306-us58wwmp 810 17 ( ( -LRB- cord-015306-us58wwmp 810 18 n=12 n=12 NNP cord-015306-us58wwmp 810 19 ) ) -RRB- cord-015306-us58wwmp 810 20 , , , cord-015306-us58wwmp 810 21 septicaemia septicaemia NN cord-015306-us58wwmp 810 22 ( ( -LRB- cord-015306-us58wwmp 810 23 n=4 n=4 NNP cord-015306-us58wwmp 810 24 ) ) -RRB- cord-015306-us58wwmp 810 25 , , , cord-015306-us58wwmp 810 26 acute acute JJ cord-015306-us58wwmp 810 27 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 810 28 ( ( -LRB- cord-015306-us58wwmp 810 29 n=2 n=2 NNS cord-015306-us58wwmp 810 30 ) ) -RRB- cord-015306-us58wwmp 810 31 , , , cord-015306-us58wwmp 810 32 malignancies malignancy NNS cord-015306-us58wwmp 810 33 ( ( -LRB- cord-015306-us58wwmp 810 34 n=2 n=2 NNS cord-015306-us58wwmp 810 35 ) ) -RRB- cord-015306-us58wwmp 810 36 , , , cord-015306-us58wwmp 810 37 malaria malaria FW cord-015306-us58wwmp 810 38 ( ( -LRB- cord-015306-us58wwmp 810 39 n=1 n=1 CD cord-015306-us58wwmp 810 40 ) ) -RRB- cord-015306-us58wwmp 810 41 , , , cord-015306-us58wwmp 810 42 HIV HIV NNP cord-015306-us58wwmp 810 43 ( ( -LRB- cord-015306-us58wwmp 810 44 n=1 n=1 NNP cord-015306-us58wwmp 810 45 ) ) -RRB- cord-015306-us58wwmp 810 46 and and CC cord-015306-us58wwmp 810 47 haemolyticuraemic haemolyticuraemic NNP cord-015306-us58wwmp 810 48 syndrome syndrome NN cord-015306-us58wwmp 810 49 ( ( -LRB- cord-015306-us58wwmp 810 50 n=1 n=1 CD cord-015306-us58wwmp 810 51 ) ) -RRB- cord-015306-us58wwmp 810 52 . . . cord-015306-us58wwmp 811 1 The the DT cord-015306-us58wwmp 811 2 aetiology aetiology NN cord-015306-us58wwmp 811 3 of of IN cord-015306-us58wwmp 811 4 IVH IVH NNP cord-015306-us58wwmp 811 5 was be VBD cord-015306-us58wwmp 811 6 secondary secondary JJ cord-015306-us58wwmp 811 7 to to IN cord-015306-us58wwmp 811 8 glucose-6-phosphate glucose-6-phosphate JJ cord-015306-us58wwmp 811 9 dehydrogenase dehydrogenase NN cord-015306-us58wwmp 811 10 ( ( -LRB- cord-015306-us58wwmp 811 11 G6PD G6PD NNP cord-015306-us58wwmp 811 12 ) ) -RRB- cord-015306-us58wwmp 811 13 deficiency deficiency NN cord-015306-us58wwmp 811 14 in in IN cord-015306-us58wwmp 811 15 4 4 CD cord-015306-us58wwmp 811 16 patients patient NNS cord-015306-us58wwmp 811 17 , , , cord-015306-us58wwmp 811 18 autoimmune autoimmune JJ cord-015306-us58wwmp 811 19 haemolyticanaemia haemolyticanaemia NN cord-015306-us58wwmp 811 20 in in IN cord-015306-us58wwmp 811 21 1 1 CD cord-015306-us58wwmp 811 22 and and CC cord-015306-us58wwmp 811 23 was be VBD cord-015306-us58wwmp 811 24 unknown unknown JJ cord-015306-us58wwmp 811 25 in in IN cord-015306-us58wwmp 811 26 the the DT cord-015306-us58wwmp 811 27 others other NNS cord-015306-us58wwmp 811 28 . . . cord-015306-us58wwmp 812 1 One one CD cord-015306-us58wwmp 812 2 of of IN cord-015306-us58wwmp 812 3 the the DT cord-015306-us58wwmp 812 4 patients patient NNS cord-015306-us58wwmp 812 5 with with IN cord-015306-us58wwmp 812 6 IVH IVH NNP cord-015306-us58wwmp 812 7 secondary secondary JJ cord-015306-us58wwmp 812 8 to to IN cord-015306-us58wwmp 812 9 G6PD G6PD NNP cord-015306-us58wwmp 812 10 deficiency deficiency NN cord-015306-us58wwmp 812 11 also also RB cord-015306-us58wwmp 812 12 had have VBD cord-015306-us58wwmp 812 13 malaria malaria NN cord-015306-us58wwmp 812 14 . . . cord-015306-us58wwmp 813 1 The the DT cord-015306-us58wwmp 813 2 number number NN cord-015306-us58wwmp 813 3 of of IN cord-015306-us58wwmp 813 4 sessions session NNS cord-015306-us58wwmp 813 5 of of IN cord-015306-us58wwmp 813 6 dialysis dialysis NN cord-015306-us58wwmp 813 7 ranged range VBD cord-015306-us58wwmp 813 8 from from IN cord-015306-us58wwmp 813 9 1 1 CD cord-015306-us58wwmp 813 10 to to IN cord-015306-us58wwmp 813 11 5 5 CD cord-015306-us58wwmp 813 12 sessions session NNS cord-015306-us58wwmp 813 13 per per IN cord-015306-us58wwmp 813 14 patient patient NN cord-015306-us58wwmp 813 15 with with IN cord-015306-us58wwmp 813 16 a a DT cord-015306-us58wwmp 813 17 modal modal JJ cord-015306-us58wwmp 813 18 value value NN cord-015306-us58wwmp 813 19 of of IN cord-015306-us58wwmp 813 20 2 2 CD cord-015306-us58wwmp 813 21 Objectives Objectives NNPS cord-015306-us58wwmp 813 22 , , , cord-015306-us58wwmp 813 23 Methods Methods NNPS cord-015306-us58wwmp 813 24 and and CC cord-015306-us58wwmp 813 25 Results result NNS cord-015306-us58wwmp 813 26 : : : cord-015306-us58wwmp 814 1 A a DT cord-015306-us58wwmp 814 2 twelve twelve CD cord-015306-us58wwmp 814 3 - - HYPH cord-015306-us58wwmp 814 4 day day NN cord-015306-us58wwmp 814 5 old old JJ cord-015306-us58wwmp 814 6 , , , cord-015306-us58wwmp 814 7 formula formula NN cord-015306-us58wwmp 814 8 - - HYPH cord-015306-us58wwmp 814 9 fed feed VBN cord-015306-us58wwmp 814 10 , , , cord-015306-us58wwmp 814 11 full full JJ cord-015306-us58wwmp 814 12 term term NN cord-015306-us58wwmp 814 13 neonate neonate NN cord-015306-us58wwmp 814 14 with with IN cord-015306-us58wwmp 814 15 unremarkable unremarkable JJ cord-015306-us58wwmp 814 16 perinatal perinatal JJ cord-015306-us58wwmp 814 17 history history NN cord-015306-us58wwmp 814 18 was be VBD cord-015306-us58wwmp 814 19 admitted admit VBN cord-015306-us58wwmp 814 20 for for IN cord-015306-us58wwmp 814 21 poor poor JJ cord-015306-us58wwmp 814 22 oral oral JJ cord-015306-us58wwmp 814 23 feeding feeding NN cord-015306-us58wwmp 814 24 and and CC cord-015306-us58wwmp 814 25 significant significant JJ cord-015306-us58wwmp 814 26 ( ( -LRB- cord-015306-us58wwmp 814 27 12 12 CD cord-015306-us58wwmp 814 28 % % NN cord-015306-us58wwmp 814 29 ) ) -RRB- cord-015306-us58wwmp 814 30 weight weight NN cord-015306-us58wwmp 814 31 loss loss NN cord-015306-us58wwmp 814 32 . . . cord-015306-us58wwmp 815 1 Physical physical JJ cord-015306-us58wwmp 815 2 examination examination NN cord-015306-us58wwmp 815 3 was be VBD cord-015306-us58wwmp 815 4 otherwise otherwise RB cord-015306-us58wwmp 815 5 unremarkable unremarkable JJ cord-015306-us58wwmp 815 6 . . . cord-015306-us58wwmp 816 1 Investigation investigation NN cord-015306-us58wwmp 816 2 showed show VBD cord-015306-us58wwmp 816 3 normal normal JJ cord-015306-us58wwmp 816 4 anion anion NN cord-015306-us58wwmp 816 5 gap gap NN cord-015306-us58wwmp 816 6 metabolic metabolic JJ cord-015306-us58wwmp 816 7 acidosis acidosis NN cord-015306-us58wwmp 816 8 , , , cord-015306-us58wwmp 816 9 hyperkalemia hyperkalemia NN cord-015306-us58wwmp 816 10 ( ( -LRB- cord-015306-us58wwmp 816 11 6.5mmol 6.5mmol CD cord-015306-us58wwmp 816 12 / / SYM cord-015306-us58wwmp 816 13 L L NNP cord-015306-us58wwmp 816 14 ) ) -RRB- cord-015306-us58wwmp 816 15 , , , cord-015306-us58wwmp 816 16 hyperurecemia hyperurecemia NNP cord-015306-us58wwmp 816 17 ( ( -LRB- cord-015306-us58wwmp 816 18 14.5mmol 14.5mmol NNP cord-015306-us58wwmp 816 19 / / SYM cord-015306-us58wwmp 816 20 L l NN cord-015306-us58wwmp 816 21 ) ) -RRB- cord-015306-us58wwmp 816 22 but but CC cord-015306-us58wwmp 816 23 normal normal JJ cord-015306-us58wwmp 816 24 creatinine creatinine NN cord-015306-us58wwmp 816 25 ( ( -LRB- cord-015306-us58wwmp 816 26 28umol 28umol NNP cord-015306-us58wwmp 816 27 / / SYM cord-015306-us58wwmp 816 28 L L NNP cord-015306-us58wwmp 816 29 ) ) -RRB- cord-015306-us58wwmp 816 30 . . . cord-015306-us58wwmp 817 1 Metabolic metabolic JJ cord-015306-us58wwmp 817 2 screen screen NN cord-015306-us58wwmp 817 3 and and CC cord-015306-us58wwmp 817 4 other other JJ cord-015306-us58wwmp 817 5 investigation investigation NN cord-015306-us58wwmp 817 6 was be VBD cord-015306-us58wwmp 817 7 unremarkable unremarkable JJ cord-015306-us58wwmp 817 8 . . . cord-015306-us58wwmp 818 1 On on IN cord-015306-us58wwmp 818 2 further further RB cord-015306-us58wwmp 818 3 questioning question VBG cord-015306-us58wwmp 818 4 parents parent NNS cord-015306-us58wwmp 818 5 has have VBZ cord-015306-us58wwmp 818 6 been be VBN cord-015306-us58wwmp 818 7 feeding feed VBG cord-015306-us58wwmp 818 8 baby baby NN cord-015306-us58wwmp 818 9 with with IN cord-015306-us58wwmp 818 10 goat goat NN cord-015306-us58wwmp 818 11 milkbased milkbased NNP cord-015306-us58wwmp 818 12 formula formula NN cord-015306-us58wwmp 818 13 since since IN cord-015306-us58wwmp 818 14 day day NN cord-015306-us58wwmp 818 15 5 5 CD cord-015306-us58wwmp 818 16 . . . cord-015306-us58wwmp 819 1 Baby Baby NNP cord-015306-us58wwmp 819 2 was be VBD cord-015306-us58wwmp 819 3 switched switch VBN cord-015306-us58wwmp 819 4 back back RB cord-015306-us58wwmp 819 5 to to IN cord-015306-us58wwmp 819 6 normal normal JJ cord-015306-us58wwmp 819 7 cow cow NN cord-015306-us58wwmp 819 8 milk milk NN cord-015306-us58wwmp 819 9 - - HYPH cord-015306-us58wwmp 819 10 based base VBN cord-015306-us58wwmp 819 11 formula formula NN cord-015306-us58wwmp 819 12 with with IN cord-015306-us58wwmp 819 13 prompt prompt JJ cord-015306-us58wwmp 819 14 resolution resolution NN cord-015306-us58wwmp 819 15 of of IN cord-015306-us58wwmp 819 16 metabolic metabolic JJ cord-015306-us58wwmp 819 17 disturbance disturbance NN cord-015306-us58wwmp 819 18 and and CC cord-015306-us58wwmp 819 19 without without IN cord-015306-us58wwmp 819 20 recurrence recurrence NN cord-015306-us58wwmp 819 21 of of IN cord-015306-us58wwmp 819 22 acidosis acidosis NN cord-015306-us58wwmp 819 23 on on IN cord-015306-us58wwmp 819 24 follow follow NN cord-015306-us58wwmp 819 25 - - HYPH cord-015306-us58wwmp 819 26 up up NN cord-015306-us58wwmp 819 27 . . . cord-015306-us58wwmp 820 1 Conclusions conclusion NNS cord-015306-us58wwmp 820 2 : : : cord-015306-us58wwmp 821 1 Goat Goat NNP cord-015306-us58wwmp 821 2 milk milk NN cord-015306-us58wwmp 821 3 is be VBZ cord-015306-us58wwmp 821 4 becoming become VBG cord-015306-us58wwmp 821 5 increasing increase VBG cord-015306-us58wwmp 821 6 popular popular JJ cord-015306-us58wwmp 821 7 to to IN cord-015306-us58wwmp 821 8 parents parent NNS cord-015306-us58wwmp 821 9 because because IN cord-015306-us58wwmp 821 10 of of IN cord-015306-us58wwmp 821 11 the the DT cord-015306-us58wwmp 821 12 myths myth NNS cord-015306-us58wwmp 821 13 associated associate VBN cord-015306-us58wwmp 821 14 ( ( -LRB- cord-015306-us58wwmp 821 15 organic organic JJ cord-015306-us58wwmp 821 16 , , , cord-015306-us58wwmp 821 17 easier easier RBR cord-015306-us58wwmp 821 18 digested digest VBN cord-015306-us58wwmp 821 19 , , , cord-015306-us58wwmp 821 20 hypoallergenic hypoallergenic JJ cord-015306-us58wwmp 821 21 , , , cord-015306-us58wwmp 821 22 better well JJR cord-015306-us58wwmp 821 23 nutrient nutrient NN cord-015306-us58wwmp 821 24 content content NN cord-015306-us58wwmp 821 25 etc etc NN cord-015306-us58wwmp 821 26 ) ) -RRB- cord-015306-us58wwmp 821 27 . . . cord-015306-us58wwmp 822 1 However however RB cord-015306-us58wwmp 822 2 there there EX cord-015306-us58wwmp 822 3 is be VBZ cord-015306-us58wwmp 822 4 good good JJ cord-015306-us58wwmp 822 5 evidence evidence NN cord-015306-us58wwmp 822 6 suggesting suggest VBG cord-015306-us58wwmp 822 7 against against IN cord-015306-us58wwmp 822 8 these these DT cord-015306-us58wwmp 822 9 misbelief misbelief NN cord-015306-us58wwmp 822 10 and and CC cord-015306-us58wwmp 822 11 there there EX cord-015306-us58wwmp 822 12 are be VBP cord-015306-us58wwmp 822 13 even even RB cord-015306-us58wwmp 822 14 reported report VBN cord-015306-us58wwmp 822 15 morbidities morbidity NNS cord-015306-us58wwmp 822 16 associated associate VBN cord-015306-us58wwmp 822 17 with with IN cord-015306-us58wwmp 822 18 ingestion ingestion NN cord-015306-us58wwmp 822 19 of of IN cord-015306-us58wwmp 822 20 goat goat NN cord-015306-us58wwmp 822 21 milkbased milkbase VBN cord-015306-us58wwmp 822 22 formula formula NN cord-015306-us58wwmp 822 23 . . . cord-015306-us58wwmp 823 1 With with IN cord-015306-us58wwmp 823 2 increasing increase VBG cord-015306-us58wwmp 823 3 appealing appealing JJ cord-015306-us58wwmp 823 4 but but CC cord-015306-us58wwmp 823 5 not not RB cord-015306-us58wwmp 823 6 necessarily necessarily RB cord-015306-us58wwmp 823 7 accurate accurate JJ cord-015306-us58wwmp 823 8 information information NN cord-015306-us58wwmp 823 9 available available JJ cord-015306-us58wwmp 823 10 on on IN cord-015306-us58wwmp 823 11 the the DT cord-015306-us58wwmp 823 12 Internet internet NN cord-015306-us58wwmp 823 13 , , , cord-015306-us58wwmp 823 14 what what WP cord-015306-us58wwmp 823 15 the the DT cord-015306-us58wwmp 823 16 public public JJ cord-015306-us58wwmp 823 17 need need NN cord-015306-us58wwmp 823 18 is be VBZ cord-015306-us58wwmp 823 19 education education NN cord-015306-us58wwmp 823 20 . . . cord-015306-us58wwmp 824 1 Objective objective NN cord-015306-us58wwmp 824 2 : : : cord-015306-us58wwmp 824 3 There there EX cord-015306-us58wwmp 824 4 have have VBP cord-015306-us58wwmp 824 5 been be VBN cord-015306-us58wwmp 824 6 great great JJ cord-015306-us58wwmp 824 7 inroads inroad NNS cord-015306-us58wwmp 824 8 made make VBN cord-015306-us58wwmp 824 9 in in IN cord-015306-us58wwmp 824 10 controlling control VBG cord-015306-us58wwmp 824 11 the the DT cord-015306-us58wwmp 824 12 scourge scourge NN cord-015306-us58wwmp 824 13 of of IN cord-015306-us58wwmp 824 14 HIV HIV NNP cord-015306-us58wwmp 824 15 in in IN cord-015306-us58wwmp 824 16 South South NNP cord-015306-us58wwmp 824 17 Africa Africa NNP cord-015306-us58wwmp 824 18 . . . cord-015306-us58wwmp 825 1 The the DT cord-015306-us58wwmp 825 2 national national JJ cord-015306-us58wwmp 825 3 PMTCT PMTCT NNP cord-015306-us58wwmp 825 4 program program NN cord-015306-us58wwmp 825 5 has have VBZ cord-015306-us58wwmp 825 6 reduced reduce VBN cord-015306-us58wwmp 825 7 the the DT cord-015306-us58wwmp 825 8 MTCT MTCT NNP cord-015306-us58wwmp 825 9 rate rate NN cord-015306-us58wwmp 825 10 to to IN cord-015306-us58wwmp 825 11 3.5 3.5 CD cord-015306-us58wwmp 825 12 % % NN cord-015306-us58wwmp 825 13 and and CC cord-015306-us58wwmp 825 14 children child NNS cord-015306-us58wwmp 825 15 infected infect VBN cord-015306-us58wwmp 825 16 prior prior RB cord-015306-us58wwmp 825 17 to to IN cord-015306-us58wwmp 825 18 these these DT cord-015306-us58wwmp 825 19 interventions intervention NNS cord-015306-us58wwmp 825 20 are be VBP cord-015306-us58wwmp 825 21 now now RB cord-015306-us58wwmp 825 22 on on IN cord-015306-us58wwmp 825 23 effective effective JJ cord-015306-us58wwmp 825 24 treatment treatment NN cord-015306-us58wwmp 825 25 programs program NNS cord-015306-us58wwmp 825 26 . . . cord-015306-us58wwmp 826 1 These these DT cord-015306-us58wwmp 826 2 children child NNS cord-015306-us58wwmp 826 3 are be VBP cord-015306-us58wwmp 826 4 now now RB cord-015306-us58wwmp 826 5 surviving survive VBG cord-015306-us58wwmp 826 6 longer long RBR cord-015306-us58wwmp 826 7 and and CC cord-015306-us58wwmp 826 8 so so RB cord-015306-us58wwmp 826 9 we -PRON- PRP cord-015306-us58wwmp 826 10 are be VBP cord-015306-us58wwmp 826 11 seeing see VBG cord-015306-us58wwmp 826 12 increased increase VBN cord-015306-us58wwmp 826 13 numbers number NNS cord-015306-us58wwmp 826 14 of of IN cord-015306-us58wwmp 826 15 HIV HIV NNP cord-015306-us58wwmp 826 16 related relate VBD cord-015306-us58wwmp 826 17 renal renal JJ cord-015306-us58wwmp 826 18 pathology pathology NN cord-015306-us58wwmp 826 19 presenting present VBG cord-015306-us58wwmp 826 20 to to IN cord-015306-us58wwmp 826 21 our -PRON- PRP$ cord-015306-us58wwmp 826 22 clinics clinic NNS cord-015306-us58wwmp 826 23 . . . cord-015306-us58wwmp 827 1 Before before IN cord-015306-us58wwmp 827 2 the the DT cord-015306-us58wwmp 827 3 widespread widespread JJ cord-015306-us58wwmp 827 4 availability availability NN cord-015306-us58wwmp 827 5 of of IN cord-015306-us58wwmp 827 6 ARV ARV NNP cord-015306-us58wwmp 827 7 's 's POS cord-015306-us58wwmp 827 8 in in IN cord-015306-us58wwmp 827 9 South South NNP cord-015306-us58wwmp 827 10 Africa Africa NNP cord-015306-us58wwmp 827 11 these these DT cord-015306-us58wwmp 827 12 children child NNS cord-015306-us58wwmp 827 13 would would MD cord-015306-us58wwmp 827 14 have have VB cord-015306-us58wwmp 827 15 been be VBN cord-015306-us58wwmp 827 16 denied deny VBN cord-015306-us58wwmp 827 17 access access NN cord-015306-us58wwmp 827 18 to to IN cord-015306-us58wwmp 827 19 our -PRON- PRP$ cord-015306-us58wwmp 827 20 program program NN cord-015306-us58wwmp 828 1 but but CC cord-015306-us58wwmp 828 2 now now RB cord-015306-us58wwmp 828 3 we -PRON- PRP cord-015306-us58wwmp 828 4 are be VBP cord-015306-us58wwmp 828 5 able able JJ cord-015306-us58wwmp 828 6 to to TO cord-015306-us58wwmp 828 7 offer offer VB cord-015306-us58wwmp 828 8 them -PRON- PRP cord-015306-us58wwmp 828 9 CRRTand crrtand IN cord-015306-us58wwmp 828 10 a a DT cord-015306-us58wwmp 828 11 transplant transplant NN cord-015306-us58wwmp 828 12 . . . cord-015306-us58wwmp 829 1 The the DT cord-015306-us58wwmp 829 2 biggest big JJS cord-015306-us58wwmp 829 3 challenge challenge NN cord-015306-us58wwmp 829 4 facing face VBG cord-015306-us58wwmp 829 5 our -PRON- PRP$ cord-015306-us58wwmp 829 6 program program NN cord-015306-us58wwmp 829 7 is be VBZ cord-015306-us58wwmp 829 8 one one CD cord-015306-us58wwmp 829 9 of of IN cord-015306-us58wwmp 829 10 the the DT cord-015306-us58wwmp 829 11 social social JJ cord-015306-us58wwmp 829 12 disintergration disintergration NN cord-015306-us58wwmp 829 13 of of IN cord-015306-us58wwmp 829 14 much much JJ cord-015306-us58wwmp 829 15 of of IN cord-015306-us58wwmp 829 16 our -PRON- PRP$ cord-015306-us58wwmp 829 17 indigent indigent JJ cord-015306-us58wwmp 829 18 population population NN cord-015306-us58wwmp 829 19 . . . cord-015306-us58wwmp 830 1 The the DT cord-015306-us58wwmp 830 2 vast vast JJ cord-015306-us58wwmp 830 3 majority majority NN cord-015306-us58wwmp 830 4 of of IN cord-015306-us58wwmp 830 5 our -PRON- PRP$ cord-015306-us58wwmp 830 6 patients patient NNS cord-015306-us58wwmp 830 7 come come VBP cord-015306-us58wwmp 830 8 from from IN cord-015306-us58wwmp 830 9 social social JJ cord-015306-us58wwmp 830 10 backgrounds background NNS cord-015306-us58wwmp 830 11 that that WDT cord-015306-us58wwmp 830 12 are be VBP cord-015306-us58wwmp 830 13 incompatible incompatible JJ cord-015306-us58wwmp 830 14 with with IN cord-015306-us58wwmp 830 15 adhering adhere VBG cord-015306-us58wwmp 830 16 to to IN cord-015306-us58wwmp 830 17 the the DT cord-015306-us58wwmp 830 18 rigours rigour NNS cord-015306-us58wwmp 830 19 of of IN cord-015306-us58wwmp 830 20 a a DT cord-015306-us58wwmp 830 21 chronic chronic JJ cord-015306-us58wwmp 830 22 renal renal JJ cord-015306-us58wwmp 830 23 program program NN cord-015306-us58wwmp 830 24 . . . cord-015306-us58wwmp 831 1 This this DT cord-015306-us58wwmp 831 2 is be VBZ cord-015306-us58wwmp 831 3 compounded compound VBN cord-015306-us58wwmp 831 4 when when WRB cord-015306-us58wwmp 831 5 the the DT cord-015306-us58wwmp 831 6 care care NN cord-015306-us58wwmp 831 7 givers giver NNS cord-015306-us58wwmp 831 8 are be VBP cord-015306-us58wwmp 831 9 themselves -PRON- PRP cord-015306-us58wwmp 831 10 ill ill JJ cord-015306-us58wwmp 831 11 or or CC cord-015306-us58wwmp 831 12 when when WRB cord-015306-us58wwmp 831 13 the the DT cord-015306-us58wwmp 831 14 child child NN cord-015306-us58wwmp 831 15 has have VBZ cord-015306-us58wwmp 831 16 a a DT cord-015306-us58wwmp 831 17 second second JJ cord-015306-us58wwmp 831 18 serious serious JJ cord-015306-us58wwmp 831 19 illness illness NN cord-015306-us58wwmp 831 20 such such JJ cord-015306-us58wwmp 831 21 as as IN cord-015306-us58wwmp 831 22 HIV HIV NNP cord-015306-us58wwmp 831 23 to to TO cord-015306-us58wwmp 831 24 deal deal VB cord-015306-us58wwmp 831 25 with with IN cord-015306-us58wwmp 831 26 . . . cord-015306-us58wwmp 832 1 Methods method NNS cord-015306-us58wwmp 832 2 : : : cord-015306-us58wwmp 832 3 We -PRON- PRP cord-015306-us58wwmp 832 4 would would MD cord-015306-us58wwmp 832 5 like like VB cord-015306-us58wwmp 832 6 to to TO cord-015306-us58wwmp 832 7 present present VB cord-015306-us58wwmp 832 8 our -PRON- PRP$ cord-015306-us58wwmp 832 9 experience experience NN cord-015306-us58wwmp 832 10 with with IN cord-015306-us58wwmp 832 11 admitting admit VBG cord-015306-us58wwmp 832 12 8 8 CD cord-015306-us58wwmp 832 13 HIV HIV NNP cord-015306-us58wwmp 832 14 positive positive JJ cord-015306-us58wwmp 832 15 children child NNS cord-015306-us58wwmp 832 16 with with IN cord-015306-us58wwmp 832 17 CKD5 CKD5 NNP cord-015306-us58wwmp 832 18 to to IN cord-015306-us58wwmp 832 19 our -PRON- PRP$ cord-015306-us58wwmp 832 20 chronic chronic JJ cord-015306-us58wwmp 832 21 program program NN cord-015306-us58wwmp 832 22 and and CC cord-015306-us58wwmp 832 23 will will MD cord-015306-us58wwmp 832 24 highlight highlight VB cord-015306-us58wwmp 832 25 the the DT cord-015306-us58wwmp 832 26 challenges challenge NNS cord-015306-us58wwmp 832 27 that that WDT cord-015306-us58wwmp 832 28 face face VBP cord-015306-us58wwmp 832 29 these these DT cord-015306-us58wwmp 832 30 families family NNS cord-015306-us58wwmp 832 31 and and CC cord-015306-us58wwmp 832 32 their -PRON- PRP$ cord-015306-us58wwmp 832 33 health health NN cord-015306-us58wwmp 832 34 care care NN cord-015306-us58wwmp 832 35 providers provider NNS cord-015306-us58wwmp 832 36 . . . cord-015306-us58wwmp 833 1 We -PRON- PRP cord-015306-us58wwmp 833 2 will will MD cord-015306-us58wwmp 833 3 describe describe VB cord-015306-us58wwmp 833 4 the the DT cord-015306-us58wwmp 833 5 social social JJ cord-015306-us58wwmp 833 6 issues issue NNS cord-015306-us58wwmp 833 7 affecting affect VBG cord-015306-us58wwmp 833 8 each each DT cord-015306-us58wwmp 833 9 family family NN cord-015306-us58wwmp 833 10 and and CC cord-015306-us58wwmp 833 11 how how WRB cord-015306-us58wwmp 833 12 they -PRON- PRP cord-015306-us58wwmp 833 13 impact impact VBP cord-015306-us58wwmp 833 14 on on IN cord-015306-us58wwmp 833 15 the the DT cord-015306-us58wwmp 833 16 child child NN cord-015306-us58wwmp 833 17 's 's POS cord-015306-us58wwmp 833 18 care care NN cord-015306-us58wwmp 833 19 . . . cord-015306-us58wwmp 834 1 Results result NNS cord-015306-us58wwmp 834 2 : : : cord-015306-us58wwmp 835 1 All all DT cord-015306-us58wwmp 835 2 8 8 CD cord-015306-us58wwmp 835 3 families family NNS cord-015306-us58wwmp 835 4 had have VBD cord-015306-us58wwmp 835 5 serious serious JJ cord-015306-us58wwmp 835 6 social social JJ cord-015306-us58wwmp 835 7 issues issue NNS cord-015306-us58wwmp 835 8 on on IN cord-015306-us58wwmp 835 9 top top NN cord-015306-us58wwmp 835 10 of of IN cord-015306-us58wwmp 835 11 having have VBG cord-015306-us58wwmp 835 12 to to TO cord-015306-us58wwmp 835 13 deal deal VB cord-015306-us58wwmp 835 14 with with IN cord-015306-us58wwmp 835 15 their -PRON- PRP$ cord-015306-us58wwmp 835 16 HIV HIV NNP cord-015306-us58wwmp 835 17 disease disease NN cord-015306-us58wwmp 835 18 . . . cord-015306-us58wwmp 836 1 All all DT cord-015306-us58wwmp 836 2 8 8 CD cord-015306-us58wwmp 836 3 families family NNS cord-015306-us58wwmp 836 4 had have VBD cord-015306-us58wwmp 836 5 extreme extreme JJ cord-015306-us58wwmp 836 6 difficulties difficulty NNS cord-015306-us58wwmp 836 7 in in IN cord-015306-us58wwmp 836 8 adhering adhere VBG cord-015306-us58wwmp 836 9 to to IN cord-015306-us58wwmp 836 10 our -PRON- PRP$ cord-015306-us58wwmp 836 11 program program NN cord-015306-us58wwmp 836 12 . . . cord-015306-us58wwmp 837 1 2/7 2/7 CD cord-015306-us58wwmp 837 2 died die VBD cord-015306-us58wwmp 837 3 as as IN cord-015306-us58wwmp 837 4 a a DT cord-015306-us58wwmp 837 5 result result NN cord-015306-us58wwmp 837 6 of of IN cord-015306-us58wwmp 837 7 non non JJ cord-015306-us58wwmp 837 8 adherence adherence NN cord-015306-us58wwmp 837 9 and and CC cord-015306-us58wwmp 837 10 of of IN cord-015306-us58wwmp 837 11 the the DT cord-015306-us58wwmp 837 12 remaining remain VBG cord-015306-us58wwmp 837 13 5 5 CD cord-015306-us58wwmp 837 14 children child NNS cord-015306-us58wwmp 837 15 only only RB cord-015306-us58wwmp 837 16 1 1 CD cord-015306-us58wwmp 837 17 is be VBZ cord-015306-us58wwmp 837 18 really really RB cord-015306-us58wwmp 837 19 coping cope VBG cord-015306-us58wwmp 837 20 well well RB cord-015306-us58wwmp 837 21 with with IN cord-015306-us58wwmp 837 22 the the DT cord-015306-us58wwmp 837 23 program program NN cord-015306-us58wwmp 837 24 . . . cord-015306-us58wwmp 838 1 3/7 3/7 CD cord-015306-us58wwmp 838 2 children child NNS cord-015306-us58wwmp 838 3 have have VBP cord-015306-us58wwmp 838 4 no no DT cord-015306-us58wwmp 838 5 living live VBG cord-015306-us58wwmp 838 6 parents parent NNS cord-015306-us58wwmp 838 7 and and CC cord-015306-us58wwmp 838 8 1 1 CD cord-015306-us58wwmp 838 9 is be VBZ cord-015306-us58wwmp 838 10 foster foster JJ cord-015306-us58wwmp 838 11 care care NN cord-015306-us58wwmp 838 12 . . . cord-015306-us58wwmp 839 1 The the DT cord-015306-us58wwmp 839 2 rest rest NN cord-015306-us58wwmp 839 3 are be VBP cord-015306-us58wwmp 839 4 either either CC cord-015306-us58wwmp 839 5 with with IN cord-015306-us58wwmp 839 6 a a DT cord-015306-us58wwmp 839 7 single single JJ cord-015306-us58wwmp 839 8 parent parent NN cord-015306-us58wwmp 839 9 or or CC cord-015306-us58wwmp 839 10 with with IN cord-015306-us58wwmp 839 11 a a DT cord-015306-us58wwmp 839 12 family family NN cord-015306-us58wwmp 839 13 relative relative NN cord-015306-us58wwmp 839 14 . . . cord-015306-us58wwmp 840 1 Conclusion conclusion NN cord-015306-us58wwmp 840 2 : : : cord-015306-us58wwmp 841 1 The the DT cord-015306-us58wwmp 841 2 huge huge JJ cord-015306-us58wwmp 841 3 difficulties difficulty NNS cord-015306-us58wwmp 841 4 facing face VBG cord-015306-us58wwmp 841 5 these these DT cord-015306-us58wwmp 841 6 patients patient NNS cord-015306-us58wwmp 841 7 is be VBZ cord-015306-us58wwmp 841 8 forcing force VBG cord-015306-us58wwmp 841 9 us -PRON- PRP cord-015306-us58wwmp 841 10 to to TO cord-015306-us58wwmp 841 11 rethink rethink VB cord-015306-us58wwmp 841 12 the the DT cord-015306-us58wwmp 841 13 criteria criterion NNS cord-015306-us58wwmp 841 14 that that WDT cord-015306-us58wwmp 841 15 should should MD cord-015306-us58wwmp 841 16 be be VB cord-015306-us58wwmp 841 17 applied apply VBN cord-015306-us58wwmp 841 18 to to IN cord-015306-us58wwmp 841 19 admitting admit VBG cord-015306-us58wwmp 841 20 these these DT cord-015306-us58wwmp 841 21 patients patient NNS cord-015306-us58wwmp 841 22 to to IN cord-015306-us58wwmp 841 23 our -PRON- PRP$ cord-015306-us58wwmp 841 24 program program NN cord-015306-us58wwmp 841 25 . . . cord-015306-us58wwmp 842 1 Restricting restrict VBG cord-015306-us58wwmp 842 2 the the DT cord-015306-us58wwmp 842 3 program program NN cord-015306-us58wwmp 842 4 to to IN cord-015306-us58wwmp 842 5 children child NNS cord-015306-us58wwmp 842 6 with with IN cord-015306-us58wwmp 842 7 these these DT cord-015306-us58wwmp 842 8 problem problem NN cord-015306-us58wwmp 842 9 seems seem VBZ cord-015306-us58wwmp 842 10 cruel cruel JJ cord-015306-us58wwmp 842 11 and and CC cord-015306-us58wwmp 842 12 we -PRON- PRP cord-015306-us58wwmp 842 13 feel feel VBP cord-015306-us58wwmp 842 14 that that IN cord-015306-us58wwmp 842 15 all all DT cord-015306-us58wwmp 842 16 options option NNS cord-015306-us58wwmp 842 17 should should MD cord-015306-us58wwmp 842 18 be be VB cord-015306-us58wwmp 842 19 considered consider VBN cord-015306-us58wwmp 842 20 before before IN cord-015306-us58wwmp 842 21 denying deny VBG cord-015306-us58wwmp 842 22 these these DT cord-015306-us58wwmp 842 23 children child NNS cord-015306-us58wwmp 842 24 access access VB cord-015306-us58wwmp 842 25 to to IN cord-015306-us58wwmp 842 26 life life NN cord-015306-us58wwmp 842 27 saving save VBG cord-015306-us58wwmp 842 28 care care NN cord-015306-us58wwmp 842 29 . . . cord-015306-us58wwmp 843 1 Abstract abstract JJ cord-015306-us58wwmp 843 2 # # NN cord-015306-us58wwmp 844 1 Most Most JJS cord-015306-us58wwmp 844 2 of of IN cord-015306-us58wwmp 844 3 the the DT cord-015306-us58wwmp 844 4 patients patient NNS cord-015306-us58wwmp 844 5 presented present VBN cord-015306-us58wwmp 844 6 during during IN cord-015306-us58wwmp 844 7 autumn autumn NN cord-015306-us58wwmp 844 8 and and CC cord-015306-us58wwmp 844 9 winter winter NN cord-015306-us58wwmp 844 10 . . . cord-015306-us58wwmp 845 1 The the DT cord-015306-us58wwmp 845 2 incidence incidence NN cord-015306-us58wwmp 845 3 of of IN cord-015306-us58wwmp 845 4 APSGN APSGN NNP cord-015306-us58wwmp 845 5 has have VBZ cord-015306-us58wwmp 845 6 decreased decrease VBN cord-015306-us58wwmp 845 7 in in IN cord-015306-us58wwmp 845 8 the the DT cord-015306-us58wwmp 845 9 past past JJ cord-015306-us58wwmp 845 10 11 11 CD cord-015306-us58wwmp 845 11 years year NNS cord-015306-us58wwmp 845 12 in in IN cord-015306-us58wwmp 845 13 Shenyang Shenyang NNP cord-015306-us58wwmp 845 14 , , , cord-015306-us58wwmp 845 15 but but CC cord-015306-us58wwmp 845 16 the the DT cord-015306-us58wwmp 845 17 proportion proportion NN cord-015306-us58wwmp 845 18 of of IN cord-015306-us58wwmp 845 19 the the DT cord-015306-us58wwmp 845 20 patients patient NNS cord-015306-us58wwmp 845 21 with with IN cord-015306-us58wwmp 845 22 acute acute JJ cord-015306-us58wwmp 845 23 kidney kidney NN cord-015306-us58wwmp 845 24 injury injury NN cord-015306-us58wwmp 845 25 ( ( -LRB- cord-015306-us58wwmp 845 26 AKI AKI NNP cord-015306-us58wwmp 845 27 ) ) -RRB- cord-015306-us58wwmp 845 28 or or CC cord-015306-us58wwmp 845 29 nephroticrange nephroticrange NNP cord-015306-us58wwmp 845 30 proteinuria proteinuria NNP cord-015306-us58wwmp 845 31 was be VBD cord-015306-us58wwmp 845 32 increased increase VBN cord-015306-us58wwmp 845 33 . . . cord-015306-us58wwmp 846 1 The the DT cord-015306-us58wwmp 846 2 proportion proportion NN cord-015306-us58wwmp 846 3 of of IN cord-015306-us58wwmp 846 4 children child NNS cord-015306-us58wwmp 846 5 with with IN cord-015306-us58wwmp 846 6 macroscopic macroscopic JJ cord-015306-us58wwmp 846 7 hematuria hematuria NN cord-015306-us58wwmp 846 8 remained remain VBD cord-015306-us58wwmp 846 9 almost almost RB cord-015306-us58wwmp 846 10 the the DT cord-015306-us58wwmp 846 11 same same JJ cord-015306-us58wwmp 846 12 during during IN cord-015306-us58wwmp 846 13 these these DT cord-015306-us58wwmp 846 14 years year NNS cord-015306-us58wwmp 846 15 . . . cord-015306-us58wwmp 847 1 Macroscopic macroscopic JJ cord-015306-us58wwmp 847 2 hematuria hematuria NNS cord-015306-us58wwmp 847 3 resolved resolve VBN cord-015306-us58wwmp 847 4 in in IN cord-015306-us58wwmp 847 5 2 2 CD cord-015306-us58wwmp 847 6 - - SYM cord-015306-us58wwmp 847 7 3 3 CD cord-015306-us58wwmp 847 8 weeks week NNS cord-015306-us58wwmp 847 9 and and CC cord-015306-us58wwmp 847 10 non non JJ cord-015306-us58wwmp 847 11 - - JJ cord-015306-us58wwmp 847 12 nephroticproteinuria nephroticproteinuria NNP cord-015306-us58wwmp 847 13 resolved resolve VBD cord-015306-us58wwmp 847 14 in in IN cord-015306-us58wwmp 847 15 1 1 CD cord-015306-us58wwmp 847 16 - - SYM cord-015306-us58wwmp 847 17 3 3 CD cord-015306-us58wwmp 847 18 weeks week NNS cord-015306-us58wwmp 847 19 . . . cord-015306-us58wwmp 848 1 The the DT cord-015306-us58wwmp 848 2 treatment treatment NN cord-015306-us58wwmp 848 3 of of IN cord-015306-us58wwmp 848 4 APSGN APSGN NNP cord-015306-us58wwmp 848 5 patients patient NNS cord-015306-us58wwmp 848 6 with with IN cord-015306-us58wwmp 848 7 nephrotic nephrotic NN cord-015306-us58wwmp 848 8 - - HYPH cord-015306-us58wwmp 848 9 proteinuria proteinuria NN cord-015306-us58wwmp 848 10 was be VBD cord-015306-us58wwmp 848 11 the the DT cord-015306-us58wwmp 848 12 same same JJ cord-015306-us58wwmp 848 13 with with IN cord-015306-us58wwmp 848 14 the the DT cord-015306-us58wwmp 848 15 children child NNS cord-015306-us58wwmp 848 16 with with IN cord-015306-us58wwmp 848 17 primary primary JJ cord-015306-us58wwmp 848 18 nephrotic nephrotic JJ cord-015306-us58wwmp 848 19 syndrome syndrome NN cord-015306-us58wwmp 848 20 and and CC cord-015306-us58wwmp 848 21 prednisone prednisone NNP cord-015306-us58wwmp 848 22 was be VBD cord-015306-us58wwmp 848 23 withdrawn withdraw VBN cord-015306-us58wwmp 848 24 in in IN cord-015306-us58wwmp 848 25 3 3 CD cord-015306-us58wwmp 848 26 - - SYM cord-015306-us58wwmp 848 27 4 4 CD cord-015306-us58wwmp 848 28 months month NNS cord-015306-us58wwmp 848 29 . . . cord-015306-us58wwmp 849 1 Some some DT cord-015306-us58wwmp 849 2 AKI AKI NNP cord-015306-us58wwmp 849 3 patients patient NNS cord-015306-us58wwmp 849 4 have have VBP cord-015306-us58wwmp 849 5 been be VBN cord-015306-us58wwmp 849 6 followed follow VBN cord-015306-us58wwmp 849 7 up up RP cord-015306-us58wwmp 849 8 for for IN cord-015306-us58wwmp 849 9 5 5 CD cord-015306-us58wwmp 849 10 years year NNS cord-015306-us58wwmp 849 11 and and CC cord-015306-us58wwmp 849 12 no no DT cord-015306-us58wwmp 849 13 patients patient NNS cord-015306-us58wwmp 849 14 with with IN cord-015306-us58wwmp 849 15 chronic chronic JJ cord-015306-us58wwmp 849 16 renal renal JJ cord-015306-us58wwmp 849 17 failure failure NN cord-015306-us58wwmp 849 18 . . . cord-015306-us58wwmp 850 1 All all DT cord-015306-us58wwmp 850 2 patients patient NNS cord-015306-us58wwmp 850 3 with with IN cord-015306-us58wwmp 850 4 microscopic microscopic JJ cord-015306-us58wwmp 850 5 hematuria hematuria NN cord-015306-us58wwmp 850 6 at at IN cord-015306-us58wwmp 850 7 onset onset NN cord-015306-us58wwmp 850 8 and and CC cord-015306-us58wwmp 850 9 30 30 CD cord-015306-us58wwmp 850 10 % % NN cord-015306-us58wwmp 850 11 patients patient NNS cord-015306-us58wwmp 850 12 with with IN cord-015306-us58wwmp 850 13 microscopic microscopic JJ cord-015306-us58wwmp 850 14 hematuria hematuria NN cord-015306-us58wwmp 850 15 after after IN cord-015306-us58wwmp 850 16 2 2 CD cord-015306-us58wwmp 850 17 years year NNS cord-015306-us58wwmp 850 18 . . . cord-015306-us58wwmp 851 1 Conclusion conclusion NN cord-015306-us58wwmp 851 2 : : : cord-015306-us58wwmp 852 1 The the DT cord-015306-us58wwmp 852 2 incidence incidence NN cord-015306-us58wwmp 852 3 of of IN cord-015306-us58wwmp 852 4 APSGN APSGN NNP cord-015306-us58wwmp 852 5 was be VBD cord-015306-us58wwmp 852 6 decreased decrease VBN cord-015306-us58wwmp 852 7 during during IN cord-015306-us58wwmp 852 8 recent recent JJ cord-015306-us58wwmp 852 9 years year NNS cord-015306-us58wwmp 852 10 . . . cord-015306-us58wwmp 853 1 The the DT cord-015306-us58wwmp 853 2 proportion proportion NN cord-015306-us58wwmp 853 3 of of IN cord-015306-us58wwmp 853 4 APSGN APSGN NNP cord-015306-us58wwmp 853 5 patients patient NNS cord-015306-us58wwmp 853 6 with with IN cord-015306-us58wwmp 853 7 AKI AKI NNP cord-015306-us58wwmp 853 8 or or CC cord-015306-us58wwmp 853 9 nephrotic nephrotic JJ cord-015306-us58wwmp 853 10 - - HYPH cord-015306-us58wwmp 853 11 range range NN cord-015306-us58wwmp 853 12 proteinuria proteinuria NN cord-015306-us58wwmp 853 13 was be VBD cord-015306-us58wwmp 853 14 increased increase VBN cord-015306-us58wwmp 853 15 . . . cord-015306-us58wwmp 854 1 The the DT cord-015306-us58wwmp 854 2 short short JJ cord-015306-us58wwmp 854 3 - - HYPH cord-015306-us58wwmp 854 4 term term NN cord-015306-us58wwmp 854 5 prognosis prognosis NN cord-015306-us58wwmp 854 6 of of IN cord-015306-us58wwmp 854 7 APSGN APSGN NNP cord-015306-us58wwmp 854 8 was be VBD cord-015306-us58wwmp 854 9 good good JJ cord-015306-us58wwmp 854 10 and and CC cord-015306-us58wwmp 854 11 minority minority NN cord-015306-us58wwmp 854 12 of of IN cord-015306-us58wwmp 854 13 the the DT cord-015306-us58wwmp 854 14 patients patient NNS cord-015306-us58wwmp 854 15 persisted persist VBD cord-015306-us58wwmp 854 16 with with IN cord-015306-us58wwmp 854 17 microscopic microscopic JJ cord-015306-us58wwmp 854 18 hematuria hematuria NN cord-015306-us58wwmp 854 19 . . . cord-015306-us58wwmp 855 1 Abstract abstract JJ cord-015306-us58wwmp 855 2 # # NN cord-015306-us58wwmp 855 3 P p NN cord-015306-us58wwmp 855 4 - - , cord-015306-us58wwmp 855 5 SAT122 SAT122 NNP cord-015306-us58wwmp 855 6 Analysis Analysis NNP cord-015306-us58wwmp 855 7 of of IN cord-015306-us58wwmp 855 8 clinical clinical JJ cord-015306-us58wwmp 855 9 manifestations manifestation NNS cord-015306-us58wwmp 855 10 and and CC cord-015306-us58wwmp 855 11 prognosis prognosis NN cord-015306-us58wwmp 855 12 in in IN cord-015306-us58wwmp 855 13 43 43 CD cord-015306-us58wwmp 855 14 children child NNS cord-015306-us58wwmp 855 15 of of IN cord-015306-us58wwmp 855 16 acute acute JJ cord-015306-us58wwmp 855 17 poststreptococcal poststreptococcal JJ cord-015306-us58wwmp 855 18 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 856 1 Objective objective NN cord-015306-us58wwmp 856 2 : : : cord-015306-us58wwmp 857 1 Crescentic crescentic JJ cord-015306-us58wwmp 857 2 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 857 3 ( ( -LRB- cord-015306-us58wwmp 857 4 GN GN NNP cord-015306-us58wwmp 857 5 ) ) -RRB- cord-015306-us58wwmp 857 6 is be VBZ cord-015306-us58wwmp 857 7 characterized characterize VBN cord-015306-us58wwmp 857 8 by by IN cord-015306-us58wwmp 857 9 severe severe JJ cord-015306-us58wwmp 857 10 infiltration infiltration NN cord-015306-us58wwmp 857 11 of of IN cord-015306-us58wwmp 857 12 massive massive JJ cord-015306-us58wwmp 857 13 inflammatory inflammatory JJ cord-015306-us58wwmp 857 14 cells cell NNS cord-015306-us58wwmp 857 15 into into IN cord-015306-us58wwmp 857 16 glomeruli glomerulus NNS cord-015306-us58wwmp 857 17 and and CC cord-015306-us58wwmp 857 18 crescent crescent NN cord-015306-us58wwmp 857 19 formation formation NN cord-015306-us58wwmp 857 20 . . . cord-015306-us58wwmp 858 1 Although although IN cord-015306-us58wwmp 858 2 renin renin NN cord-015306-us58wwmp 858 3 angiotensin angiotensin NN cord-015306-us58wwmp 858 4 system system NN cord-015306-us58wwmp 858 5 ( ( -LRB- cord-015306-us58wwmp 858 6 RAS RAS NNP cord-015306-us58wwmp 858 7 ) ) -RRB- cord-015306-us58wwmp 858 8 is be VBZ cord-015306-us58wwmp 858 9 the the DT cord-015306-us58wwmp 858 10 key key JJ cord-015306-us58wwmp 858 11 player player NN cord-015306-us58wwmp 858 12 in in IN cord-015306-us58wwmp 858 13 renal renal JJ cord-015306-us58wwmp 858 14 injury injury NN cord-015306-us58wwmp 858 15 , , , cord-015306-us58wwmp 858 16 the the DT cord-015306-us58wwmp 858 17 impact impact NN cord-015306-us58wwmp 858 18 of of IN cord-015306-us58wwmp 858 19 direct direct JJ cord-015306-us58wwmp 858 20 renin renin NN cord-015306-us58wwmp 858 21 inhibitor inhibitor NN cord-015306-us58wwmp 858 22 on on IN cord-015306-us58wwmp 858 23 glomerular glomerular JJ cord-015306-us58wwmp 858 24 crescent crescent NN cord-015306-us58wwmp 858 25 formation formation NN cord-015306-us58wwmp 858 26 is be VBZ cord-015306-us58wwmp 858 27 not not RB cord-015306-us58wwmp 858 28 elucidated elucidate VBN cord-015306-us58wwmp 858 29 yet yet RB cord-015306-us58wwmp 858 30 . . . cord-015306-us58wwmp 859 1 Methods method NNS cord-015306-us58wwmp 859 2 : : : cord-015306-us58wwmp 859 3 To to TO cord-015306-us58wwmp 859 4 examine examine VB cord-015306-us58wwmp 859 5 whether whether IN cord-015306-us58wwmp 859 6 direct direct JJ cord-015306-us58wwmp 859 7 renin renin NN cord-015306-us58wwmp 859 8 inhibitor inhibitor NN cord-015306-us58wwmp 859 9 ameliorate ameliorate VB cord-015306-us58wwmp 859 10 renal renal JJ cord-015306-us58wwmp 859 11 injury injury NN cord-015306-us58wwmp 859 12 in in IN cord-015306-us58wwmp 859 13 crescentic crescentic JJ cord-015306-us58wwmp 859 14 GN GN NNP cord-015306-us58wwmp 859 15 , , , cord-015306-us58wwmp 859 16 we -PRON- PRP cord-015306-us58wwmp 859 17 investigated investigate VBD cord-015306-us58wwmp 859 18 renal renal JJ cord-015306-us58wwmp 859 19 injury injury NN cord-015306-us58wwmp 859 20 induced induce VBN cord-015306-us58wwmp 859 21 by by IN cord-015306-us58wwmp 859 22 antiglomerular antiglomerular NNP cord-015306-us58wwmp 859 23 basement basement NN cord-015306-us58wwmp 859 24 membrane membrane NN cord-015306-us58wwmp 859 25 ( ( -LRB- cord-015306-us58wwmp 859 26 GBM GBM NNP cord-015306-us58wwmp 859 27 ) ) -RRB- cord-015306-us58wwmp 859 28 antibodies antibody NNS cord-015306-us58wwmp 859 29 in in IN cord-015306-us58wwmp 859 30 Wistar Wistar NNP cord-015306-us58wwmp 859 31 Kyoto Kyoto NNP cord-015306-us58wwmp 859 32 rats rat NNS cord-015306-us58wwmp 859 33 treated treat VBN cord-015306-us58wwmp 859 34 with with IN cord-015306-us58wwmp 859 35 direct direct JJ cord-015306-us58wwmp 859 36 renin renin NN cord-015306-us58wwmp 859 37 inhibitor inhibitor NN cord-015306-us58wwmp 859 38 , , , cord-015306-us58wwmp 859 39 aliskiren aliskiren NNP cord-015306-us58wwmp 859 40 . . . cord-015306-us58wwmp 860 1 In in IN cord-015306-us58wwmp 860 2 addition addition NN cord-015306-us58wwmp 860 3 , , , cord-015306-us58wwmp 860 4 using use VBG cord-015306-us58wwmp 860 5 cultured cultured JJ cord-015306-us58wwmp 860 6 glomerular glomerular JJ cord-015306-us58wwmp 860 7 mesangial mesangial JJ cord-015306-us58wwmp 860 8 cell cell NN cord-015306-us58wwmp 860 9 ( ( -LRB- cord-015306-us58wwmp 860 10 MCs MCs NNP cord-015306-us58wwmp 860 11 ) ) -RRB- cord-015306-us58wwmp 860 12 and and CC cord-015306-us58wwmp 860 13 parietal parietal JJ cord-015306-us58wwmp 860 14 epithelial epithelial JJ cord-015306-us58wwmp 860 15 cell cell NN cord-015306-us58wwmp 860 16 ( ( -LRB- cord-015306-us58wwmp 860 17 PECs pec NNS cord-015306-us58wwmp 860 18 ) ) -RRB- cord-015306-us58wwmp 860 19 , , , cord-015306-us58wwmp 860 20 we -PRON- PRP cord-015306-us58wwmp 860 21 examined examine VBD cord-015306-us58wwmp 860 22 whether whether IN cord-015306-us58wwmp 860 23 recombinant recombinant JJ cord-015306-us58wwmp 860 24 renin renin NN cord-015306-us58wwmp 860 25 could could MD cord-015306-us58wwmp 860 26 induce induce VB cord-015306-us58wwmp 860 27 monocyte monocyte NNP cord-015306-us58wwmp 860 28 chemoattractant chemoattractant NNP cord-015306-us58wwmp 860 29 protein-1 protein-1 NNP cord-015306-us58wwmp 860 30 ( ( -LRB- cord-015306-us58wwmp 860 31 MCP-1 MCP-1 NNP cord-015306-us58wwmp 860 32 ) ) -RRB- cord-015306-us58wwmp 860 33 expression expression NN cord-015306-us58wwmp 860 34 and and CC cord-015306-us58wwmp 860 35 cell cell NN cord-015306-us58wwmp 860 36 proliferation proliferation NN cord-015306-us58wwmp 860 37 , , , cord-015306-us58wwmp 860 38 respectively respectively RB cord-015306-us58wwmp 860 39 . . . cord-015306-us58wwmp 861 1 Results result NNS cord-015306-us58wwmp 861 2 : : : cord-015306-us58wwmp 862 1 An an DT cord-015306-us58wwmp 862 2 anti anti JJ cord-015306-us58wwmp 862 3 - - JJ cord-015306-us58wwmp 862 4 GBM GBM NNP cord-015306-us58wwmp 862 5 nephritis nephritis NN cord-015306-us58wwmp 862 6 model model NN cord-015306-us58wwmp 862 7 developed develop VBD cord-015306-us58wwmp 862 8 progressive progressive JJ cord-015306-us58wwmp 862 9 proteinuria proteinuria NN cord-015306-us58wwmp 862 10 and and CC cord-015306-us58wwmp 862 11 glomerular glomerular JJ cord-015306-us58wwmp 862 12 crescent crescent NN cord-015306-us58wwmp 862 13 formation formation NN cord-015306-us58wwmp 862 14 , , , cord-015306-us58wwmp 862 15 accompanied accompany VBN cord-015306-us58wwmp 862 16 by by IN cord-015306-us58wwmp 862 17 increased increase VBN cord-015306-us58wwmp 862 18 expression expression NN cord-015306-us58wwmp 862 19 of of IN cord-015306-us58wwmp 862 20 MCP-1 MCP-1 NNP cord-015306-us58wwmp 862 21 and and CC cord-015306-us58wwmp 862 22 ( ( -LRB- cord-015306-us58wwmp 862 23 pro)renin pro)renin JJ cord-015306-us58wwmp 862 24 receptor receptor NN cord-015306-us58wwmp 862 25 . . . cord-015306-us58wwmp 863 1 Interestingly interestingly RB cord-015306-us58wwmp 863 2 , , , cord-015306-us58wwmp 863 3 ( ( -LRB- cord-015306-us58wwmp 863 4 pro)renin pro)renin JJ cord-015306-us58wwmp 863 5 receptor receptor NN cord-015306-us58wwmp 863 6 expressed express VBD cord-015306-us58wwmp 863 7 strongly strongly RB cord-015306-us58wwmp 863 8 in in IN cord-015306-us58wwmp 863 9 the the DT cord-015306-us58wwmp 863 10 crescent crescent NNP cord-015306-us58wwmp 863 11 formation formation NN cord-015306-us58wwmp 863 12 area area NN cord-015306-us58wwmp 863 13 in in IN cord-015306-us58wwmp 863 14 diseased diseased JJ cord-015306-us58wwmp 863 15 glomeruli glomerulus NNS cord-015306-us58wwmp 863 16 . . . cord-015306-us58wwmp 864 1 Proteinuria Proteinuria NNP cord-015306-us58wwmp 864 2 was be VBD cord-015306-us58wwmp 864 3 significantly significantly RB cord-015306-us58wwmp 864 4 reduced reduce VBN cord-015306-us58wwmp 864 5 by by IN cord-015306-us58wwmp 864 6 the the DT cord-015306-us58wwmp 864 7 treatment treatment NN cord-015306-us58wwmp 864 8 of of IN cord-015306-us58wwmp 864 9 aliskiren aliskiren NNP cord-015306-us58wwmp 864 10 . . . cord-015306-us58wwmp 865 1 Then then RB cord-015306-us58wwmp 865 2 , , , cord-015306-us58wwmp 865 3 aliskiren aliskiren NNP cord-015306-us58wwmp 865 4 markedly markedly RB cord-015306-us58wwmp 865 5 ameliorated ameliorate VBD cord-015306-us58wwmp 865 6 renal renal JJ cord-015306-us58wwmp 865 7 injury injury NN cord-015306-us58wwmp 865 8 ( ( -LRB- cord-015306-us58wwmp 865 9 % % NN cord-015306-us58wwmp 865 10 glomerular glomerular JJ cord-015306-us58wwmp 865 11 crescent crescent NN cord-015306-us58wwmp 865 12 : : : cord-015306-us58wwmp 866 1 26.0 26.0 CD cord-015306-us58wwmp 866 2 + + CC cord-015306-us58wwmp 866 3 /− /− . cord-015306-us58wwmp 866 4 1.7 1.7 CD cord-015306-us58wwmp 866 5 % % NN cord-015306-us58wwmp 866 6 ) ) -RRB- cord-015306-us58wwmp 866 7 compared compare VBN cord-015306-us58wwmp 866 8 to to IN cord-015306-us58wwmp 866 9 vehicle vehicle NN cord-015306-us58wwmp 866 10 treatment treatment NN cord-015306-us58wwmp 866 11 ( ( -LRB- cord-015306-us58wwmp 866 12 59.6 59.6 CD cord-015306-us58wwmp 866 13 + + CC cord-015306-us58wwmp 866 14 /− /− . cord-015306-us58wwmp 866 15 3.6 3.6 CD cord-015306-us58wwmp 866 16 % % NN cord-015306-us58wwmp 866 17 ) ) -RRB- cord-015306-us58wwmp 866 18 . . . cord-015306-us58wwmp 867 1 Excretion excretion NN cord-015306-us58wwmp 867 2 of of IN cord-015306-us58wwmp 867 3 urinary urinary JJ cord-015306-us58wwmp 867 4 protein protein NN cord-015306-us58wwmp 867 5 in in IN cord-015306-us58wwmp 867 6 a a DT cord-015306-us58wwmp 867 7 group group NN cord-015306-us58wwmp 867 8 of of IN cord-015306-us58wwmp 867 9 rats rat NNS cord-015306-us58wwmp 867 10 treated treat VBN cord-015306-us58wwmp 867 11 with with IN cord-015306-us58wwmp 867 12 aliskiren aliskiren NNP cord-015306-us58wwmp 867 13 were be VBD cord-015306-us58wwmp 867 14 significantly significantly RB cord-015306-us58wwmp 867 15 reduced reduce VBN cord-015306-us58wwmp 867 16 compared compare VBN cord-015306-us58wwmp 867 17 to to IN cord-015306-us58wwmp 867 18 vehicle vehicle NN cord-015306-us58wwmp 867 19 - - HYPH cord-015306-us58wwmp 867 20 treated treat VBN cord-015306-us58wwmp 867 21 rats rat NNS cord-015306-us58wwmp 867 22 . . . cord-015306-us58wwmp 868 1 Aliskiren Aliskiren NNP cord-015306-us58wwmp 868 2 treatment treatment NN cord-015306-us58wwmp 868 3 markedly markedly RB cord-015306-us58wwmp 868 4 decreased decrease VBD cord-015306-us58wwmp 868 5 MCP-1 MCP-1 NNP cord-015306-us58wwmp 869 1 and and CC cord-015306-us58wwmp 869 2 ( ( -LRB- cord-015306-us58wwmp 869 3 pro)renin pro)renin JJ cord-015306-us58wwmp 869 4 receptor receptor NN cord-015306-us58wwmp 869 5 mRNA mRNA NNP cord-015306-us58wwmp 869 6 levels level NNS cord-015306-us58wwmp 869 7 in in IN cord-015306-us58wwmp 869 8 the the DT cord-015306-us58wwmp 869 9 diseased diseased JJ cord-015306-us58wwmp 869 10 kidney kidney NN cord-015306-us58wwmp 869 11 . . . cord-015306-us58wwmp 870 1 Next next RB cord-015306-us58wwmp 870 2 , , , cord-015306-us58wwmp 870 3 primary primary JJ cord-015306-us58wwmp 870 4 cultured cultured JJ cord-015306-us58wwmp 870 5 MCs MCs NNPS cord-015306-us58wwmp 870 6 stimulated stimulate VBN cord-015306-us58wwmp 870 7 by by IN cord-015306-us58wwmp 870 8 recombinant recombinant JJ cord-015306-us58wwmp 870 9 renin renin NN cord-015306-us58wwmp 870 10 showed show VBD cord-015306-us58wwmp 870 11 significant significant JJ cord-015306-us58wwmp 870 12 increases increase NNS cord-015306-us58wwmp 870 13 of of IN cord-015306-us58wwmp 870 14 MCP-1 MCP-1 NNP cord-015306-us58wwmp 870 15 mRNA mRNA NNP cord-015306-us58wwmp 870 16 expression expression NN cord-015306-us58wwmp 870 17 . . . cord-015306-us58wwmp 871 1 Furthermore furthermore RB cord-015306-us58wwmp 871 2 , , , cord-015306-us58wwmp 871 3 primary primary JJ cord-015306-us58wwmp 871 4 cultured cultured JJ cord-015306-us58wwmp 871 5 PECs pec NNS cord-015306-us58wwmp 871 6 showed show VBD cord-015306-us58wwmp 871 7 an an DT cord-015306-us58wwmp 871 8 increase increase NN cord-015306-us58wwmp 871 9 in in IN cord-015306-us58wwmp 871 10 recombinant recombinant JJ cord-015306-us58wwmp 871 11 renininduced renininduced JJ cord-015306-us58wwmp 871 12 cell cell NN cord-015306-us58wwmp 871 13 proliferation proliferation NN cord-015306-us58wwmp 871 14 . . . cord-015306-us58wwmp 872 1 Conclusion conclusion NN cord-015306-us58wwmp 872 2 : : : cord-015306-us58wwmp 873 1 These these DT cord-015306-us58wwmp 873 2 data datum NNS cord-015306-us58wwmp 873 3 suggest suggest VBP cord-015306-us58wwmp 873 4 that that IN cord-015306-us58wwmp 873 5 therapeutic therapeutic JJ cord-015306-us58wwmp 873 6 strategy strategy NN cord-015306-us58wwmp 873 7 of of IN cord-015306-us58wwmp 873 8 direct direct JJ cord-015306-us58wwmp 873 9 renin renin NN cord-015306-us58wwmp 873 10 inhibitor inhibitor NN cord-015306-us58wwmp 873 11 may may MD cord-015306-us58wwmp 873 12 prove prove VB cord-015306-us58wwmp 873 13 beneficial beneficial JJ cord-015306-us58wwmp 873 14 for for IN cord-015306-us58wwmp 873 15 crescentic crescentic JJ cord-015306-us58wwmp 873 16 GN GN NNP cord-015306-us58wwmp 873 17 by by IN cord-015306-us58wwmp 873 18 the the DT cord-015306-us58wwmp 873 19 suppression suppression NN cord-015306-us58wwmp 873 20 of of IN cord-015306-us58wwmp 873 21 the the DT cord-015306-us58wwmp 873 22 RAS RAS NNP cord-015306-us58wwmp 873 23 activation activation NN cord-015306-us58wwmp 873 24 and and CC cord-015306-us58wwmp 873 25 the the DT cord-015306-us58wwmp 873 26 decrease decrease NN cord-015306-us58wwmp 873 27 of of IN cord-015306-us58wwmp 873 28 inflammation inflammation NN cord-015306-us58wwmp 873 29 and and CC cord-015306-us58wwmp 873 30 cell cell NN cord-015306-us58wwmp 873 31 proliferation proliferation NN cord-015306-us58wwmp 873 32 in in IN cord-015306-us58wwmp 873 33 glomerular glomerular JJ cord-015306-us58wwmp 873 34 crescent crescent NN cord-015306-us58wwmp 873 35 via via IN cord-015306-us58wwmp 873 36 ( ( -LRB- cord-015306-us58wwmp 873 37 pro)renin pro)renin JJ cord-015306-us58wwmp 873 38 receptor receptor NN cord-015306-us58wwmp 873 39 . . . cord-015306-us58wwmp 874 1 An an DT cord-015306-us58wwmp 874 2 update update NN cord-015306-us58wwmp 874 3 on on IN cord-015306-us58wwmp 874 4 management management NN cord-015306-us58wwmp 874 5 of of IN cord-015306-us58wwmp 874 6 acute acute JJ cord-015306-us58wwmp 874 7 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 874 8 in in IN cord-015306-us58wwmp 874 9 children child NNS cord-015306-us58wwmp 874 10 Objective Objective NNP cord-015306-us58wwmp 874 11 : : : cord-015306-us58wwmp 874 12 To to TO cord-015306-us58wwmp 874 13 analyze analyze VB cord-015306-us58wwmp 874 14 the the DT cord-015306-us58wwmp 874 15 clinical clinical JJ cord-015306-us58wwmp 874 16 effects effect NNS cord-015306-us58wwmp 874 17 , , , cord-015306-us58wwmp 874 18 safety safety NN cord-015306-us58wwmp 874 19 , , , cord-015306-us58wwmp 874 20 and and CC cord-015306-us58wwmp 874 21 significance significance NN cord-015306-us58wwmp 874 22 of of IN cord-015306-us58wwmp 874 23 leflunomide leflunomide NN cord-015306-us58wwmp 874 24 combined combine VBN cord-015306-us58wwmp 874 25 with with IN cord-015306-us58wwmp 874 26 hormone hormone NN cord-015306-us58wwmp 874 27 in in IN cord-015306-us58wwmp 874 28 the the DT cord-015306-us58wwmp 874 29 treatment treatment NN cord-015306-us58wwmp 874 30 of of IN cord-015306-us58wwmp 874 31 children child NNS cord-015306-us58wwmp 874 32 with with IN cord-015306-us58wwmp 874 33 refractory refractory JJ cord-015306-us58wwmp 874 34 nephrotic nephrotic JJ cord-015306-us58wwmp 874 35 syndrome syndrome NN cord-015306-us58wwmp 874 36 . . . cord-015306-us58wwmp 875 1 Methods method NNS cord-015306-us58wwmp 875 2 : : : cord-015306-us58wwmp 875 3 Collected collect VBN cord-015306-us58wwmp 875 4 60 60 CD cord-015306-us58wwmp 875 5 cases case NNS cord-015306-us58wwmp 875 6 patients patient NNS cord-015306-us58wwmp 875 7 in in IN cord-015306-us58wwmp 875 8 our -PRON- PRP$ cord-015306-us58wwmp 875 9 hospital hospital NN cord-015306-us58wwmp 875 10 in in IN cord-015306-us58wwmp 875 11 children child NNS cord-015306-us58wwmp 875 12 with with IN cord-015306-us58wwmp 875 13 refractory refractory JJ cord-015306-us58wwmp 875 14 nephroticsyndrome nephroticsyndrome NN cord-015306-us58wwmp 875 15 , , , cord-015306-us58wwmp 875 16 and and CC cord-015306-us58wwmp 875 17 randomly randomly RB cord-015306-us58wwmp 875 18 divided divide VBD cord-015306-us58wwmp 875 19 into into IN cord-015306-us58wwmp 875 20 30 30 CD cord-015306-us58wwmp 875 21 cases case NNS cord-015306-us58wwmp 875 22 of of IN cord-015306-us58wwmp 875 23 the the DT cord-015306-us58wwmp 875 24 control control NN cord-015306-us58wwmp 875 25 group group NN cord-015306-us58wwmp 875 26 and and CC cord-015306-us58wwmp 875 27 treatment treatment NN cord-015306-us58wwmp 875 28 group group NN cord-015306-us58wwmp 875 29 . . . cord-015306-us58wwmp 876 1 Control control NN cord-015306-us58wwmp 876 2 group group NN cord-015306-us58wwmp 876 3 was be VBD cord-015306-us58wwmp 876 4 treated treat VBN cord-015306-us58wwmp 876 5 with with IN cord-015306-us58wwmp 876 6 mycophenolatemofetil mycophenolatemofetil NNP cord-015306-us58wwmp 876 7 ( ( -LRB- cord-015306-us58wwmp 876 8 MMF)andhormone mmf)andhormone UH cord-015306-us58wwmp 876 9 , , , cord-015306-us58wwmp 876 10 the the DT cord-015306-us58wwmp 876 11 treatment treatment NN cord-015306-us58wwmp 876 12 group group NN cord-015306-us58wwmp 876 13 was be VBD cord-015306-us58wwmp 876 14 treated treat VBN cord-015306-us58wwmp 876 15 with with IN cord-015306-us58wwmp 876 16 leflunomide leflunomide NN cord-015306-us58wwmp 876 17 ( ( -LRB- cord-015306-us58wwmp 876 18 LET let VB cord-015306-us58wwmp 876 19 ) ) -RRB- cord-015306-us58wwmp 876 20 and and CC cord-015306-us58wwmp 876 21 hormone hormone NN cord-015306-us58wwmp 876 22 . . . cord-015306-us58wwmp 877 1 Measured measure VBN cord-015306-us58wwmp 877 2 and and CC cord-015306-us58wwmp 877 3 compared compare VBD cord-015306-us58wwmp 877 4 the the DT cord-015306-us58wwmp 877 5 changes change NNS cord-015306-us58wwmp 877 6 before before IN cord-015306-us58wwmp 877 7 and and CC cord-015306-us58wwmp 877 8 after after IN cord-015306-us58wwmp 877 9 treatment treatment NN cord-015306-us58wwmp 877 10 of of IN cord-015306-us58wwmp 877 11 24h 24h CD cord-015306-us58wwmp 877 12 urinary urinary JJ cord-015306-us58wwmp 877 13 protein protein NN cord-015306-us58wwmp 877 14 excretion excretion NN cord-015306-us58wwmp 877 15 , , , cord-015306-us58wwmp 877 16 TC TC NNP cord-015306-us58wwmp 877 17 , , , cord-015306-us58wwmp 877 18 ALT ALT NNP cord-015306-us58wwmp 877 19 , , , cord-015306-us58wwmp 877 20 Cr Cr NNP cord-015306-us58wwmp 877 21 , , , cord-015306-us58wwmp 877 22 BUN BUN NNP cord-015306-us58wwmp 877 23 Clinical clinical JJ cord-015306-us58wwmp 877 24 efficacy efficacy NN cord-015306-us58wwmp 877 25 and and CC cord-015306-us58wwmp 877 26 complications complication NNS cord-015306-us58wwmp 877 27 . . . cord-015306-us58wwmp 878 1 Results result NNS cord-015306-us58wwmp 878 2 : : : cord-015306-us58wwmp 879 1 The the DT cord-015306-us58wwmp 879 2 two two CD cord-015306-us58wwmp 879 3 groups group NNS cord-015306-us58wwmp 879 4 after after IN cord-015306-us58wwmp 879 5 6 6 CD cord-015306-us58wwmp 879 6 months month NNS cord-015306-us58wwmp 879 7 of of IN cord-015306-us58wwmp 879 8 treatment treatment NN cord-015306-us58wwmp 879 9 , , , cord-015306-us58wwmp 879 10 24 24 CD cord-015306-us58wwmp 879 11 h h NNP cord-015306-us58wwmp 879 12 urinary urinary JJ cord-015306-us58wwmp 879 13 protein protein NN cord-015306-us58wwmp 879 14 , , , cord-015306-us58wwmp 879 15 plasma plasma NN cord-015306-us58wwmp 879 16 albumin albumin NN cord-015306-us58wwmp 879 17 , , , cord-015306-us58wwmp 879 18 total total JJ cord-015306-us58wwmp 879 19 serum serum NN cord-015306-us58wwmp 879 20 cholesterol cholesterol NN cord-015306-us58wwmp 879 21 , , , cord-015306-us58wwmp 879 22 serum serum NN cord-015306-us58wwmp 879 23 creatinine creatinine NN cord-015306-us58wwmp 879 24 and and CC cord-015306-us58wwmp 879 25 blood blood NN cord-015306-us58wwmp 879 26 urea urea NN cord-015306-us58wwmp 879 27 nitrogen nitrogen NN cord-015306-us58wwmp 879 28 and and CC cord-015306-us58wwmp 879 29 other other JJ cord-015306-us58wwmp 879 30 indicators indicator NNS cord-015306-us58wwmp 879 31 were be VBD cord-015306-us58wwmp 879 32 significantly significantly RB cord-015306-us58wwmp 879 33 better well JJR cord-015306-us58wwmp 879 34 than than IN cord-015306-us58wwmp 879 35 before before IN cord-015306-us58wwmp 879 36 treatment treatment NN cord-015306-us58wwmp 879 37 and and CC cord-015306-us58wwmp 879 38 has have VBZ cord-015306-us58wwmp 879 39 a a DT cord-015306-us58wwmp 879 40 statistically statistically RB cord-015306-us58wwmp 879 41 significant significant JJ cord-015306-us58wwmp 879 42 ( ( -LRB- cord-015306-us58wwmp 879 43 P p NN cord-015306-us58wwmp 879 44 < < XX cord-015306-us58wwmp 879 45 0.05 0.05 CD cord-015306-us58wwmp 879 46 ) ) -RRB- cord-015306-us58wwmp 879 47 ; ; : cord-015306-us58wwmp 879 48 The the DT cord-015306-us58wwmp 879 49 overall overall JJ cord-015306-us58wwmp 879 50 response response NN cord-015306-us58wwmp 879 51 rate rate NN cord-015306-us58wwmp 879 52 in in IN cord-015306-us58wwmp 879 53 the the DT cord-015306-us58wwmp 879 54 control control NN cord-015306-us58wwmp 879 55 group group NN cord-015306-us58wwmp 879 56 and and CC cord-015306-us58wwmp 879 57 treatment treatment NN cord-015306-us58wwmp 879 58 group group NN cord-015306-us58wwmp 879 59 were be VBD cord-015306-us58wwmp 879 60 83.33 83.33 CD cord-015306-us58wwmp 879 61 % % NN cord-015306-us58wwmp 879 62 and and CC cord-015306-us58wwmp 879 63 86.67 86.67 CD cord-015306-us58wwmp 879 64 % % NN cord-015306-us58wwmp 879 65 . . . cord-015306-us58wwmp 880 1 Conclusion conclusion NN cord-015306-us58wwmp 880 2 : : : cord-015306-us58wwmp 881 1 The the DT cord-015306-us58wwmp 881 2 application application NN cord-015306-us58wwmp 881 3 of of IN cord-015306-us58wwmp 881 4 leflunomide leflunomide NN cord-015306-us58wwmp 881 5 combined combine VBN cord-015306-us58wwmp 881 6 with with IN cord-015306-us58wwmp 881 7 hormone hormone NN cord-015306-us58wwmp 881 8 treatment treatment NN cord-015306-us58wwmp 881 9 of of IN cord-015306-us58wwmp 881 10 children child NNS cord-015306-us58wwmp 881 11 with with IN cord-015306-us58wwmp 881 12 refractory refractory JJ cord-015306-us58wwmp 881 13 nephrotic nephrotic JJ cord-015306-us58wwmp 881 14 syndrome syndrome NN cord-015306-us58wwmp 881 15 can can MD cord-015306-us58wwmp 881 16 make make VB cord-015306-us58wwmp 881 17 the the DT cord-015306-us58wwmp 881 18 disease disease NN cord-015306-us58wwmp 881 19 to to TO cord-015306-us58wwmp 881 20 be be VB cord-015306-us58wwmp 881 21 effectively effectively RB cord-015306-us58wwmp 881 22 alleviated alleviate VBN cord-015306-us58wwmp 881 23 , , , cord-015306-us58wwmp 881 24 The the DT cord-015306-us58wwmp 881 25 clinical clinical JJ cord-015306-us58wwmp 881 26 results result NNS cord-015306-us58wwmp 881 27 were be VBD cord-015306-us58wwmp 881 28 satisfactory satisfactory JJ cord-015306-us58wwmp 881 29 , , , cord-015306-us58wwmp 881 30 safe safe JJ cord-015306-us58wwmp 881 31 , , , cord-015306-us58wwmp 881 32 and and CC cord-015306-us58wwmp 881 33 fewer few JJR cord-015306-us58wwmp 881 34 complications complication NNS cord-015306-us58wwmp 881 35 , , , cord-015306-us58wwmp 881 36 It -PRON- PRP cord-015306-us58wwmp 881 37 is be VBZ cord-015306-us58wwmp 881 38 worthy worthy JJ cord-015306-us58wwmp 881 39 of of IN cord-015306-us58wwmp 881 40 promotion promotion NN cord-015306-us58wwmp 881 41 . . . cord-015306-us58wwmp 882 1 Objective objective NN cord-015306-us58wwmp 882 2 : : : cord-015306-us58wwmp 883 1 Post post JJ cord-015306-us58wwmp 883 2 - - JJ cord-015306-us58wwmp 883 3 streptococcal streptococcal JJ cord-015306-us58wwmp 883 4 acute acute JJ cord-015306-us58wwmp 883 5 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 883 6 ( ( -LRB- cord-015306-us58wwmp 883 7 PSAGN PSAGN NNP cord-015306-us58wwmp 883 8 ) ) -RRB- cord-015306-us58wwmp 883 9 is be VBZ cord-015306-us58wwmp 883 10 a a DT cord-015306-us58wwmp 883 11 familiar familiar JJ cord-015306-us58wwmp 883 12 disease disease NN cord-015306-us58wwmp 883 13 in in IN cord-015306-us58wwmp 883 14 children child NNS cord-015306-us58wwmp 883 15 . . . cord-015306-us58wwmp 884 1 Misdiagnosis misdiagnosis NN cord-015306-us58wwmp 884 2 might may MD cord-015306-us58wwmp 884 3 occur occur VB cord-015306-us58wwmp 884 4 when when WRB cord-015306-us58wwmp 884 5 it -PRON- PRP cord-015306-us58wwmp 884 6 is be VBZ cord-015306-us58wwmp 884 7 presented present VBN cord-015306-us58wwmp 884 8 with with IN cord-015306-us58wwmp 884 9 atypical atypical JJ cord-015306-us58wwmp 884 10 symptoms symptom NNS cord-015306-us58wwmp 884 11 . . . cord-015306-us58wwmp 885 1 Here here RB cord-015306-us58wwmp 885 2 we -PRON- PRP cord-015306-us58wwmp 885 3 report report VBP cord-015306-us58wwmp 885 4 a a DT cord-015306-us58wwmp 885 5 12-year 12-year JJ cord-015306-us58wwmp 885 6 - - HYPH cord-015306-us58wwmp 885 7 old old JJ cord-015306-us58wwmp 885 8 girl girl NN cord-015306-us58wwmp 885 9 presented present VBN cord-015306-us58wwmp 885 10 with with IN cord-015306-us58wwmp 885 11 acute acute JJ cord-015306-us58wwmp 885 12 heart heart NN cord-015306-us58wwmp 885 13 failure failure NN cord-015306-us58wwmp 885 14 which which WDT cord-015306-us58wwmp 885 15 was be VBD cord-015306-us58wwmp 885 16 finally finally RB cord-015306-us58wwmp 885 17 diagnosed diagnose VBN cord-015306-us58wwmp 885 18 comorbidity comorbidity NN cord-015306-us58wwmp 885 19 of of IN cord-015306-us58wwmp 885 20 PSAGN PSAGN NNP cord-015306-us58wwmp 885 21 and and CC cord-015306-us58wwmp 885 22 Graves Graves NNP cord-015306-us58wwmp 885 23 ' ' POS cord-015306-us58wwmp 885 24 disease disease NN cord-015306-us58wwmp 885 25 . . . cord-015306-us58wwmp 886 1 Methods method NNS cord-015306-us58wwmp 886 2 : : : cord-015306-us58wwmp 886 3 retrospectively retrospectively RB cord-015306-us58wwmp 886 4 review review VB cord-015306-us58wwmp 886 5 the the DT cord-015306-us58wwmp 886 6 history history NN cord-015306-us58wwmp 886 7 of of IN cord-015306-us58wwmp 886 8 the the DT cord-015306-us58wwmp 886 9 patient patient NN cord-015306-us58wwmp 886 10 . . . cord-015306-us58wwmp 887 1 The the DT cord-015306-us58wwmp 887 2 girl girl NN cord-015306-us58wwmp 887 3 was be VBD cord-015306-us58wwmp 887 4 admitted admit VBN cord-015306-us58wwmp 887 5 to to IN cord-015306-us58wwmp 887 6 our -PRON- PRP$ cord-015306-us58wwmp 887 7 hospital hospital NN cord-015306-us58wwmp 887 8 with with IN cord-015306-us58wwmp 887 9 cough cough NN cord-015306-us58wwmp 887 10 , , , cord-015306-us58wwmp 887 11 shortness shortness NN cord-015306-us58wwmp 887 12 of of IN cord-015306-us58wwmp 887 13 breath breath NN cord-015306-us58wwmp 887 14 and and CC cord-015306-us58wwmp 887 15 chest chest NN cord-015306-us58wwmp 887 16 tightness tightness NN cord-015306-us58wwmp 887 17 , , , cord-015306-us58wwmp 887 18 without without IN cord-015306-us58wwmp 887 19 any any DT cord-015306-us58wwmp 887 20 other other JJ cord-015306-us58wwmp 887 21 obvious obvious JJ cord-015306-us58wwmp 887 22 symptoms symptom NNS cord-015306-us58wwmp 887 23 and and CC cord-015306-us58wwmp 887 24 history history NN cord-015306-us58wwmp 887 25 of of IN cord-015306-us58wwmp 887 26 illness illness NN cord-015306-us58wwmp 887 27 . . . cord-015306-us58wwmp 888 1 The the DT cord-015306-us58wwmp 888 2 examination examination NN cord-015306-us58wwmp 888 3 of of IN cord-015306-us58wwmp 888 4 cardiac cardiac JJ cord-015306-us58wwmp 888 5 color color NN cord-015306-us58wwmp 888 6 ultrasound ultrasound NN cord-015306-us58wwmp 888 7 showed show VBD cord-015306-us58wwmp 888 8 mitral mitral JJ cord-015306-us58wwmp 888 9 insufficiency insufficiency NN cord-015306-us58wwmp 888 10 with with IN cord-015306-us58wwmp 888 11 severe severe JJ cord-015306-us58wwmp 888 12 mitral mitral JJ cord-015306-us58wwmp 888 13 regurgitation regurgitation NN cord-015306-us58wwmp 888 14 and and CC cord-015306-us58wwmp 888 15 heart heart NN cord-015306-us58wwmp 888 16 enlargement enlargement NN cord-015306-us58wwmp 888 17 . . . cord-015306-us58wwmp 889 1 Other other JJ cord-015306-us58wwmp 889 2 examinations examination NNS cord-015306-us58wwmp 889 3 also also RB cord-015306-us58wwmp 889 4 found find VBD cord-015306-us58wwmp 889 5 she -PRON- PRP cord-015306-us58wwmp 889 6 had have VBD cord-015306-us58wwmp 889 7 hypertention hypertention NN cord-015306-us58wwmp 889 8 , , , cord-015306-us58wwmp 889 9 mild mild JJ cord-015306-us58wwmp 889 10 anomalies anomaly NNS cord-015306-us58wwmp 889 11 of of IN cord-015306-us58wwmp 889 12 urinalysis urinalysis NN cord-015306-us58wwmp 889 13 , , , cord-015306-us58wwmp 889 14 hypocomplementemia hypocomplementemia NNP cord-015306-us58wwmp 889 15 , , , cord-015306-us58wwmp 889 16 hypoalbuminemia hypoalbuminemia NN cord-015306-us58wwmp 889 17 , , , cord-015306-us58wwmp 889 18 hyperthyroidism hyperthyroidism NN cord-015306-us58wwmp 889 19 and and CC cord-015306-us58wwmp 889 20 elevated elevated JJ cord-015306-us58wwmp 889 21 antistreptolysin antistreptolysin NNP cord-015306-us58wwmp 889 22 O. O. NNP cord-015306-us58wwmp 889 23 First First NNP cord-015306-us58wwmp 890 1 we -PRON- PRP cord-015306-us58wwmp 890 2 diagnosed diagnose VBD cord-015306-us58wwmp 890 3 her -PRON- PRP$ cord-015306-us58wwmp 890 4 illness illness NN cord-015306-us58wwmp 890 5 as as IN cord-015306-us58wwmp 890 6 rheumatic rheumatic JJ cord-015306-us58wwmp 890 7 disease disease NN cord-015306-us58wwmp 890 8 . . . cord-015306-us58wwmp 891 1 After after IN cord-015306-us58wwmp 891 2 two two CD cord-015306-us58wwmp 891 3 weeks week NNS cord-015306-us58wwmp 891 4 treatment treatment NN cord-015306-us58wwmp 891 5 with with IN cord-015306-us58wwmp 891 6 rest rest NN cord-015306-us58wwmp 891 7 , , , cord-015306-us58wwmp 891 8 fluid fluid NN cord-015306-us58wwmp 891 9 and and CC cord-015306-us58wwmp 891 10 sodium sodium NN cord-015306-us58wwmp 891 11 restriction restriction NN cord-015306-us58wwmp 891 12 , , , cord-015306-us58wwmp 891 13 controlling control VBG cord-015306-us58wwmp 891 14 blood blood NN cord-015306-us58wwmp 891 15 pression pression NN cord-015306-us58wwmp 891 16 , , , cord-015306-us58wwmp 891 17 diuresis diuresis NN cord-015306-us58wwmp 891 18 and and CC cord-015306-us58wwmp 891 19 methimazole methimazole NN cord-015306-us58wwmp 891 20 , , , cord-015306-us58wwmp 891 21 the the DT cord-015306-us58wwmp 891 22 girl girl NN cord-015306-us58wwmp 891 23 recovered recover VBD cord-015306-us58wwmp 891 24 very very RB cord-015306-us58wwmp 891 25 well well RB cord-015306-us58wwmp 891 26 . . . cord-015306-us58wwmp 892 1 She -PRON- PRP cord-015306-us58wwmp 892 2 had have VBD cord-015306-us58wwmp 892 3 no no DT cord-015306-us58wwmp 892 4 any any DT cord-015306-us58wwmp 892 5 symptom symptom NN cord-015306-us58wwmp 892 6 with with IN cord-015306-us58wwmp 892 7 normal normal JJ cord-015306-us58wwmp 892 8 urinalysis urinalysis NN cord-015306-us58wwmp 892 9 and and CC cord-015306-us58wwmp 892 10 blood blood NN cord-015306-us58wwmp 892 11 pressure pressure NN cord-015306-us58wwmp 892 12 , , . cord-015306-us58wwmp 893 1 the the DT cord-015306-us58wwmp 893 2 result result NN cord-015306-us58wwmp 893 3 of of IN cord-015306-us58wwmp 893 4 reexamination reexamination NN cord-015306-us58wwmp 893 5 of of IN cord-015306-us58wwmp 893 6 Cardiac cardiac JJ cord-015306-us58wwmp 893 7 color color NN cord-015306-us58wwmp 893 8 ultrasound ultrasound NN cord-015306-us58wwmp 893 9 was be VBD cord-015306-us58wwmp 893 10 normal normal JJ cord-015306-us58wwmp 893 11 , , , cord-015306-us58wwmp 893 12 her -PRON- PRP$ cord-015306-us58wwmp 893 13 hypocomplementemia hypocomplementemia NN cord-015306-us58wwmp 893 14 and and CC cord-015306-us58wwmp 893 15 hyperthyroidism hyperthyroidism NN cord-015306-us58wwmp 893 16 were be VBD cord-015306-us58wwmp 893 17 improved improve VBN cord-015306-us58wwmp 893 18 significantly significantly RB cord-015306-us58wwmp 893 19 . . . cord-015306-us58wwmp 894 1 Finally finally RB cord-015306-us58wwmp 894 2 she -PRON- PRP cord-015306-us58wwmp 894 3 was be VBD cord-015306-us58wwmp 894 4 diagnosed diagnose VBN cord-015306-us58wwmp 894 5 as as IN cord-015306-us58wwmp 894 6 co co NN cord-015306-us58wwmp 894 7 - - NN cord-015306-us58wwmp 894 8 morbidity morbidity NN cord-015306-us58wwmp 894 9 of of IN cord-015306-us58wwmp 894 10 PSAGN PSAGN NNP cord-015306-us58wwmp 894 11 and and CC cord-015306-us58wwmp 894 12 Graves Graves NNP cord-015306-us58wwmp 894 13 ' ' POS cord-015306-us58wwmp 894 14 disease disease NN cord-015306-us58wwmp 894 15 . . . cord-015306-us58wwmp 895 1 Conclusion conclusion NN cord-015306-us58wwmp 895 2 : : : cord-015306-us58wwmp 895 3 PSAGN PSAGN NNP cord-015306-us58wwmp 895 4 with with IN cord-015306-us58wwmp 895 5 atypical atypical JJ cord-015306-us58wwmp 895 6 symptoms symptom NNS cord-015306-us58wwmp 895 7 at at IN cord-015306-us58wwmp 895 8 presentation presentation NN cord-015306-us58wwmp 895 9 should should MD cord-015306-us58wwmp 895 10 be be VB cord-015306-us58wwmp 895 11 paid pay VBN cord-015306-us58wwmp 895 12 more more JJR cord-015306-us58wwmp 895 13 attention attention NN cord-015306-us58wwmp 895 14 , , , cord-015306-us58wwmp 895 15 especially especially RB cord-015306-us58wwmp 895 16 when when WRB cord-015306-us58wwmp 895 17 it -PRON- PRP cord-015306-us58wwmp 895 18 is be VBZ cord-015306-us58wwmp 895 19 also also RB cord-015306-us58wwmp 895 20 has have VBZ cord-015306-us58wwmp 895 21 co co NN cord-015306-us58wwmp 895 22 - - NN cord-015306-us58wwmp 895 23 morbidity morbidity NN cord-015306-us58wwmp 895 24 . . . cord-015306-us58wwmp 896 1 Abstract abstract JJ cord-015306-us58wwmp 896 2 # # NN cord-015306-us58wwmp 896 3 P p NN cord-015306-us58wwmp 896 4 - - HYPH cord-015306-us58wwmp 896 5 SAT128 SAT128 NNP cord-015306-us58wwmp 896 6 Report Report NNP cord-015306-us58wwmp 896 7 of of IN cord-015306-us58wwmp 896 8 a a DT cord-015306-us58wwmp 896 9 child child NN cord-015306-us58wwmp 896 10 with with IN cord-015306-us58wwmp 896 11 idiopathic idiopathic JJ cord-015306-us58wwmp 896 12 cryoglobulinemia cryoglobulinemia NN cord-015306-us58wwmp 897 1 Idiopathic idiopathic JJ cord-015306-us58wwmp 897 2 cryoglobulinemia cryoglobulinemia NN cord-015306-us58wwmp 897 3 is be VBZ cord-015306-us58wwmp 897 4 rare rare JJ cord-015306-us58wwmp 897 5 to to TO cord-015306-us58wwmp 897 6 see see VB cord-015306-us58wwmp 897 7 in in IN cord-015306-us58wwmp 897 8 child child NN cord-015306-us58wwmp 897 9 . . . cord-015306-us58wwmp 898 1 Here here RB cord-015306-us58wwmp 898 2 we -PRON- PRP cord-015306-us58wwmp 898 3 report report VBP cord-015306-us58wwmp 898 4 a a DT cord-015306-us58wwmp 898 5 child child NN cord-015306-us58wwmp 898 6 with with IN cord-015306-us58wwmp 898 7 typical typical JJ cord-015306-us58wwmp 898 8 manifestations manifestation NNS cord-015306-us58wwmp 898 9 of of IN cord-015306-us58wwmp 898 10 cryoglobulinemia cryoglobulinemia NN cord-015306-us58wwmp 898 11 . . . cord-015306-us58wwmp 899 1 The the DT cord-015306-us58wwmp 899 2 subjected subjected JJ cord-015306-us58wwmp 899 3 child child NN cord-015306-us58wwmp 899 4 was be VBD cord-015306-us58wwmp 899 5 male male JJ cord-015306-us58wwmp 899 6 , , , cord-015306-us58wwmp 899 7 6 6 CD cord-015306-us58wwmp 899 8 years year NNS cord-015306-us58wwmp 899 9 and and CC cord-015306-us58wwmp 899 10 4 4 CD cord-015306-us58wwmp 899 11 months month NNS cord-015306-us58wwmp 899 12 , , , cord-015306-us58wwmp 899 13 He -PRON- PRP cord-015306-us58wwmp 899 14 had have VBD cord-015306-us58wwmp 899 15 repeated repeat VBN cord-015306-us58wwmp 899 16 rashes rash NNS cord-015306-us58wwmp 899 17 , , , cord-015306-us58wwmp 899 18 itching itching NN cord-015306-us58wwmp 899 19 , , , cord-015306-us58wwmp 899 20 desquamation desquamation NN cord-015306-us58wwmp 899 21 on on IN cord-015306-us58wwmp 899 22 his -PRON- PRP$ cord-015306-us58wwmp 899 23 fingertips fingertip NNS cord-015306-us58wwmp 899 24 for for IN cord-015306-us58wwmp 899 25 more more JJR cord-015306-us58wwmp 899 26 than than IN cord-015306-us58wwmp 899 27 two two CD cord-015306-us58wwmp 899 28 years year NNS cord-015306-us58wwmp 899 29 , , , cord-015306-us58wwmp 899 30 accompanied accompany VBN cord-015306-us58wwmp 899 31 with with IN cord-015306-us58wwmp 899 32 recurrent recurrent JJ cord-015306-us58wwmp 899 33 miliary miliary JJ cord-015306-us58wwmp 899 34 reddish reddish JJ cord-015306-us58wwmp 899 35 rashes rash NNS cord-015306-us58wwmp 899 36 on on IN cord-015306-us58wwmp 899 37 the the DT cord-015306-us58wwmp 899 38 trunk trunk NN cord-015306-us58wwmp 899 39 and and CC cord-015306-us58wwmp 899 40 limbs limb NNS cord-015306-us58wwmp 899 41 for for IN cord-015306-us58wwmp 899 42 more more JJR cord-015306-us58wwmp 899 43 than than IN cord-015306-us58wwmp 899 44 one one CD cord-015306-us58wwmp 899 45 year year NN cord-015306-us58wwmp 899 46 , , , cord-015306-us58wwmp 899 47 transient transient JJ cord-015306-us58wwmp 899 48 arthralgia arthralgia NN cord-015306-us58wwmp 899 49 for for IN cord-015306-us58wwmp 899 50 2 2 CD cord-015306-us58wwmp 899 51 weeks week NNS cord-015306-us58wwmp 899 52 , , , cord-015306-us58wwmp 899 53 and and CC cord-015306-us58wwmp 899 54 edema edema NN cord-015306-us58wwmp 899 55 and and CC cord-015306-us58wwmp 899 56 oliguria oliguria NN cord-015306-us58wwmp 899 57 for for IN cord-015306-us58wwmp 899 58 10 10 CD cord-015306-us58wwmp 899 59 days day NNS cord-015306-us58wwmp 899 60 before before IN cord-015306-us58wwmp 899 61 he -PRON- PRP cord-015306-us58wwmp 899 62 was be VBD cord-015306-us58wwmp 899 63 admitted admit VBN cord-015306-us58wwmp 899 64 to to IN cord-015306-us58wwmp 899 65 our -PRON- PRP$ cord-015306-us58wwmp 899 66 hospital hospital NN cord-015306-us58wwmp 899 67 . . . cord-015306-us58wwmp 900 1 He -PRON- PRP cord-015306-us58wwmp 900 2 was be VBD cord-015306-us58wwmp 900 3 treated treat VBN cord-015306-us58wwmp 900 4 as as IN cord-015306-us58wwmp 900 5 atopic atopic JJ cord-015306-us58wwmp 900 6 dermatitis dermatitis NN cord-015306-us58wwmp 900 7 all all PDT cord-015306-us58wwmp 900 8 the the DT cord-015306-us58wwmp 900 9 time time NN cord-015306-us58wwmp 900 10 . . . cord-015306-us58wwmp 901 1 But but CC cord-015306-us58wwmp 901 2 the the DT cord-015306-us58wwmp 901 3 rashes rash NNS cord-015306-us58wwmp 901 4 were be VBD cord-015306-us58wwmp 901 5 recurrent recurrent JJ cord-015306-us58wwmp 901 6 . . . cord-015306-us58wwmp 902 1 Erythema erythema NN cord-015306-us58wwmp 902 2 could could MD cord-015306-us58wwmp 902 3 be be VB cord-015306-us58wwmp 902 4 seen see VBN cord-015306-us58wwmp 902 5 after after IN cord-015306-us58wwmp 902 6 desquamation desquamation NN cord-015306-us58wwmp 902 7 . . . cord-015306-us58wwmp 903 1 2 2 CD cord-015306-us58wwmp 903 2 weeks week NNS cord-015306-us58wwmp 903 3 before before IN cord-015306-us58wwmp 903 4 admission admission NN cord-015306-us58wwmp 903 5 , , , cord-015306-us58wwmp 903 6 he -PRON- PRP cord-015306-us58wwmp 903 7 had have VBD cord-015306-us58wwmp 903 8 arthralgia arthralgia NNP cord-015306-us58wwmp 903 9 on on IN cord-015306-us58wwmp 903 10 the the DT cord-015306-us58wwmp 903 11 right right JJ cord-015306-us58wwmp 903 12 knee knee NN cord-015306-us58wwmp 903 13 , , , cord-015306-us58wwmp 903 14 2 2 CD cord-015306-us58wwmp 903 15 days day NNS cord-015306-us58wwmp 903 16 later later RB cord-015306-us58wwmp 903 17 on on IN cord-015306-us58wwmp 903 18 left left JJ cord-015306-us58wwmp 903 19 knee knee NN cord-015306-us58wwmp 903 20 without without IN cord-015306-us58wwmp 903 21 swelling swell VBG cord-015306-us58wwmp 903 22 , , , cord-015306-us58wwmp 903 23 both both DT cord-015306-us58wwmp 903 24 were be VBD cord-015306-us58wwmp 903 25 retrieved retrieve VBN cord-015306-us58wwmp 903 26 spontaneously spontaneously RB cord-015306-us58wwmp 903 27 . . . cord-015306-us58wwmp 904 1 X x NN cord-015306-us58wwmp 904 2 - - NN cord-015306-us58wwmp 904 3 ray ray NN cord-015306-us58wwmp 904 4 of of IN cord-015306-us58wwmp 904 5 the the DT cord-015306-us58wwmp 904 6 knees knee NNS cord-015306-us58wwmp 904 7 revealed reveal VBD cord-015306-us58wwmp 904 8 no no DT cord-015306-us58wwmp 904 9 abnormal abnormal JJ cord-015306-us58wwmp 904 10 . . . cord-015306-us58wwmp 905 1 Ten ten CD cord-015306-us58wwmp 905 2 days day NNS cord-015306-us58wwmp 905 3 before before IN cord-015306-us58wwmp 905 4 admission admission NN cord-015306-us58wwmp 905 5 , , , cord-015306-us58wwmp 905 6 edema edema NN cord-015306-us58wwmp 905 7 and and CC cord-015306-us58wwmp 905 8 decreased decrease VBD cord-015306-us58wwmp 905 9 urine urine NN cord-015306-us58wwmp 905 10 output output NN cord-015306-us58wwmp 905 11 was be VBD cord-015306-us58wwmp 905 12 notice notice NN cord-015306-us58wwmp 905 13 without without IN cord-015306-us58wwmp 905 14 gross gross JJ cord-015306-us58wwmp 905 15 hematuria hematuria NN cord-015306-us58wwmp 905 16 . . . cord-015306-us58wwmp 906 1 Physical physical JJ cord-015306-us58wwmp 906 2 examination examination NN cord-015306-us58wwmp 906 3 in in IN cord-015306-us58wwmp 906 4 local local JJ cord-015306-us58wwmp 906 5 hospital hospital NN cord-015306-us58wwmp 906 6 revealed reveal VBD cord-015306-us58wwmp 906 7 blood blood NN cord-015306-us58wwmp 906 8 pressure pressure NN cord-015306-us58wwmp 906 9 140/108 140/108 CD cord-015306-us58wwmp 906 10 mmHg mmHg NNS cord-015306-us58wwmp 906 11 , , , cord-015306-us58wwmp 906 12 Needlelike Needlelike NNP cord-015306-us58wwmp 906 13 erythematous erythematous JJ cord-015306-us58wwmp 906 14 maculopapules maculopapule NNS cord-015306-us58wwmp 906 15 in in IN cord-015306-us58wwmp 906 16 his -PRON- PRP$ cord-015306-us58wwmp 906 17 hands hand NNS cord-015306-us58wwmp 906 18 and and CC cord-015306-us58wwmp 906 19 feet foot NNS cord-015306-us58wwmp 906 20 . . . cord-015306-us58wwmp 907 1 Urine urine NN cord-015306-us58wwmp 907 2 test test NN cord-015306-us58wwmp 907 3 revealed reveal VBD cord-015306-us58wwmp 907 4 protein protein NN cord-015306-us58wwmp 907 5 5g 5g NNS cord-015306-us58wwmp 907 6 / / SYM cord-015306-us58wwmp 907 7 L L NNP cord-015306-us58wwmp 907 8 , , , cord-015306-us58wwmp 907 9 RBC RBC NNP cord-015306-us58wwmp 907 10 164 164 CD cord-015306-us58wwmp 907 11 / / SYM cord-015306-us58wwmp 907 12 ul ul NN cord-015306-us58wwmp 907 13 , , , cord-015306-us58wwmp 907 14 no no DT cord-015306-us58wwmp 907 15 casts cast NNS cord-015306-us58wwmp 907 16 . . . cord-015306-us58wwmp 908 1 Serum serum NN cord-015306-us58wwmp 908 2 BUN bun NN cord-015306-us58wwmp 908 3 was be VBD cord-015306-us58wwmp 908 4 32.41mmol 32.41mmol NNP cord-015306-us58wwmp 908 5 / / SYM cord-015306-us58wwmp 908 6 L L NNP cord-015306-us58wwmp 908 7 , , , cord-015306-us58wwmp 908 8 Cr Cr NNP cord-015306-us58wwmp 908 9 116umol 116umol NNP cord-015306-us58wwmp 908 10 / / SYM cord-015306-us58wwmp 908 11 L L NNP cord-015306-us58wwmp 908 12 , , , cord-015306-us58wwmp 908 13 TCO2 TCO2 NNP cord-015306-us58wwmp 908 14 11mmol 11mmol NNP cord-015306-us58wwmp 908 15 / / SYM cord-015306-us58wwmp 908 16 L L NNP cord-015306-us58wwmp 908 17 , , , cord-015306-us58wwmp 908 18 C3 c3 NN cord-015306-us58wwmp 908 19 0.47 0.47 CD cord-015306-us58wwmp 908 20 g g NN cord-015306-us58wwmp 909 1 /L. /L. . cord-015306-us58wwmp 910 1 He -PRON- PRP cord-015306-us58wwmp 910 2 was be VBD cord-015306-us58wwmp 910 3 sent send VBN cord-015306-us58wwmp 910 4 to to IN cord-015306-us58wwmp 910 5 another another DT cord-015306-us58wwmp 910 6 hospital hospital NN cord-015306-us58wwmp 910 7 2 2 CD cord-015306-us58wwmp 910 8 days day NNS cord-015306-us58wwmp 910 9 later later RB cord-015306-us58wwmp 910 10 . . . cord-015306-us58wwmp 911 1 There there RB cord-015306-us58wwmp 911 2 , , , cord-015306-us58wwmp 911 3 prednisone prednisone VBG cord-015306-us58wwmp 911 4 25 25 CD cord-015306-us58wwmp 911 5 mg mg NN cord-015306-us58wwmp 911 6 per per IN cord-015306-us58wwmp 911 7 day day NN cord-015306-us58wwmp 911 8 was be VBD cord-015306-us58wwmp 911 9 given give VBN cord-015306-us58wwmp 911 10 . . . cord-015306-us58wwmp 912 1 As as IN cord-015306-us58wwmp 912 2 a a DT cord-015306-us58wwmp 912 3 result result NN cord-015306-us58wwmp 912 4 , , , cord-015306-us58wwmp 912 5 the the DT cord-015306-us58wwmp 912 6 urine urine NN cord-015306-us58wwmp 912 7 output output NN cord-015306-us58wwmp 912 8 increased increase VBD cord-015306-us58wwmp 912 9 gradually gradually RB cord-015306-us58wwmp 912 10 , , , cord-015306-us58wwmp 912 11 but but CC cord-015306-us58wwmp 912 12 serum serum NN cord-015306-us58wwmp 912 13 BUN bun NN cord-015306-us58wwmp 912 14 and and CC cord-015306-us58wwmp 912 15 Cr Cr NNP cord-015306-us58wwmp 912 16 remained remain VBD cord-015306-us58wwmp 912 17 high high JJ cord-015306-us58wwmp 912 18 , , , cord-015306-us58wwmp 912 19 so so RB cord-015306-us58wwmp 912 20 he -PRON- PRP cord-015306-us58wwmp 912 21 was be VBD cord-015306-us58wwmp 912 22 referred refer VBN cord-015306-us58wwmp 912 23 to to IN cord-015306-us58wwmp 912 24 our -PRON- PRP$ cord-015306-us58wwmp 912 25 hospital hospital NN cord-015306-us58wwmp 912 26 . . . cord-015306-us58wwmp 913 1 Renal renal JJ cord-015306-us58wwmp 913 2 biopsy biopsy NN cord-015306-us58wwmp 913 3 indicated indicate VBD cord-015306-us58wwmp 913 4 membrane membrane NN cord-015306-us58wwmp 913 5 proliferation proliferation NN cord-015306-us58wwmp 913 6 glomerular glomerular JJ cord-015306-us58wwmp 913 7 nephritis nephritis NN cord-015306-us58wwmp 913 8 with with IN cord-015306-us58wwmp 913 9 abundant abundant JJ cord-015306-us58wwmp 913 10 microthrombus microthrombus NN cord-015306-us58wwmp 913 11 . . . cord-015306-us58wwmp 914 1 The the DT cord-015306-us58wwmp 914 2 diagnosis diagnosis NN cord-015306-us58wwmp 914 3 of of IN cord-015306-us58wwmp 914 4 cryoglobulinemia cryoglobulinemia NNP cord-015306-us58wwmp 914 5 was be VBD cord-015306-us58wwmp 914 6 suggested suggest VBN cord-015306-us58wwmp 914 7 . . . cord-015306-us58wwmp 915 1 After after IN cord-015306-us58wwmp 915 2 that that DT cord-015306-us58wwmp 915 3 serum serum NN cord-015306-us58wwmp 915 4 cryoglobulin cryoglobulin NN cord-015306-us58wwmp 915 5 and and CC cord-015306-us58wwmp 915 6 Serum serum NN cord-015306-us58wwmp 915 7 protein protein NN cord-015306-us58wwmp 915 8 electrophoresis electrophoresis NN cord-015306-us58wwmp 915 9 were be VBD cord-015306-us58wwmp 915 10 tested test VBN cord-015306-us58wwmp 915 11 18 18 CD cord-015306-us58wwmp 915 12 days day NNS cord-015306-us58wwmp 915 13 after after IN cord-015306-us58wwmp 915 14 prednisone prednisone NNP cord-015306-us58wwmp 915 15 was be VBD cord-015306-us58wwmp 915 16 given give VBN cord-015306-us58wwmp 915 17 , , , cord-015306-us58wwmp 915 18 both both DT cord-015306-us58wwmp 915 19 were be VBD cord-015306-us58wwmp 915 20 normal normal JJ cord-015306-us58wwmp 915 21 . . . cord-015306-us58wwmp 916 1 Etiological etiological JJ cord-015306-us58wwmp 916 2 examinations examination NNS cord-015306-us58wwmp 916 3 , , , cord-015306-us58wwmp 916 4 included include VBD cord-015306-us58wwmp 916 5 hepatitis hepatitis NN cord-015306-us58wwmp 916 6 virus virus NN cord-015306-us58wwmp 916 7 A A NNP cord-015306-us58wwmp 916 8 , , , cord-015306-us58wwmp 916 9 B B NNP cord-015306-us58wwmp 916 10 , , , cord-015306-us58wwmp 916 11 C C NNP cord-015306-us58wwmp 916 12 , , , cord-015306-us58wwmp 916 13 D D NNP cord-015306-us58wwmp 916 14 , , , cord-015306-us58wwmp 916 15 E E NNP cord-015306-us58wwmp 916 16 , , , cord-015306-us58wwmp 916 17 G G NNP cord-015306-us58wwmp 916 18 were be VBD cord-015306-us58wwmp 916 19 all all DT cord-015306-us58wwmp 916 20 negative negative JJ cord-015306-us58wwmp 916 21 ; ; : cord-015306-us58wwmp 916 22 antibodies antibody NNS cord-015306-us58wwmp 916 23 of of IN cord-015306-us58wwmp 916 24 HIV HIV NNP cord-015306-us58wwmp 916 25 , , , cord-015306-us58wwmp 916 26 syphilis syphili NNS cord-015306-us58wwmp 916 27 , , , cord-015306-us58wwmp 916 28 Toxo Toxo NNP cord-015306-us58wwmp 916 29 , , , cord-015306-us58wwmp 916 30 CMV CMV NNP cord-015306-us58wwmp 916 31 , , , cord-015306-us58wwmp 916 32 RVB RVB NNP cord-015306-us58wwmp 916 33 , , , cord-015306-us58wwmp 916 34 RSV RSV NNP cord-015306-us58wwmp 916 35 , , , cord-015306-us58wwmp 916 36 HSV HSV NNP cord-015306-us58wwmp 916 37 , , , cord-015306-us58wwmp 916 38 EB EB NNP cord-015306-us58wwmp 916 39 , , , cord-015306-us58wwmp 916 40 ADV ADV NNP cord-015306-us58wwmp 916 41 , , , cord-015306-us58wwmp 916 42 and and CC cord-015306-us58wwmp 917 1 Rickett Rickett NNP cord-015306-us58wwmp 917 2 's 's POS cord-015306-us58wwmp 917 3 organism organism NN cord-015306-us58wwmp 917 4 were be VBD cord-015306-us58wwmp 917 5 all all DT cord-015306-us58wwmp 917 6 negative negative JJ cord-015306-us58wwmp 917 7 , , , cord-015306-us58wwmp 917 8 MP MP NNP cord-015306-us58wwmp 917 9 - - HYPH cord-015306-us58wwmp 917 10 IgM IgM NNP cord-015306-us58wwmp 917 11 1:40 1:40 CD cord-015306-us58wwmp 917 12 . . . cord-015306-us58wwmp 918 1 Antinuclear antinuclear JJ cord-015306-us58wwmp 918 2 antibodies antibody NNS cord-015306-us58wwmp 918 3 of of IN cord-015306-us58wwmp 918 4 SLE SLE NNP cord-015306-us58wwmp 918 5 , , , cord-015306-us58wwmp 918 6 ANCA ANCA NNP cord-015306-us58wwmp 918 7 and and CC cord-015306-us58wwmp 918 8 antiphospholipid antiphospholipid NNP cord-015306-us58wwmp 918 9 antibodies antibody NNS cord-015306-us58wwmp 918 10 were be VBD cord-015306-us58wwmp 918 11 all all DT cord-015306-us58wwmp 918 12 negative negative JJ cord-015306-us58wwmp 918 13 . . . cord-015306-us58wwmp 919 1 So so RB cord-015306-us58wwmp 919 2 idiopathic idiopathic JJ cord-015306-us58wwmp 919 3 cyoglobulinemia cyoglobulinemia NN cord-015306-us58wwmp 919 4 was be VBD cord-015306-us58wwmp 919 5 more more RBR cord-015306-us58wwmp 919 6 favored favor VBN cord-015306-us58wwmp 919 7 . . . cord-015306-us58wwmp 920 1 The the DT cord-015306-us58wwmp 920 2 treatment treatment NN cord-015306-us58wwmp 920 3 of of IN cord-015306-us58wwmp 920 4 prednisone prednisone NN cord-015306-us58wwmp 920 5 25 25 CD cord-015306-us58wwmp 920 6 mg mg NNP cord-015306-us58wwmp 920 7 per per IN cord-015306-us58wwmp 920 8 day day NN cord-015306-us58wwmp 920 9 was be VBD cord-015306-us58wwmp 920 10 continued continue VBN cord-015306-us58wwmp 920 11 after after IN cord-015306-us58wwmp 920 12 admission admission NN cord-015306-us58wwmp 920 13 . . . cord-015306-us58wwmp 921 1 He -PRON- PRP cord-015306-us58wwmp 921 2 restored restore VBD cord-015306-us58wwmp 921 3 gradually gradually RB cord-015306-us58wwmp 921 4 . . . cord-015306-us58wwmp 922 1 Prednisone Prednisone NNP cord-015306-us58wwmp 922 2 was be VBD cord-015306-us58wwmp 922 3 taped tape VBN cord-015306-us58wwmp 922 4 down down RP cord-015306-us58wwmp 922 5 gradually gradually RB cord-015306-us58wwmp 922 6 . . . cord-015306-us58wwmp 923 1 Now now RB cord-015306-us58wwmp 923 2 prednisone prednisone NNP cord-015306-us58wwmp 923 3 has have VBZ cord-015306-us58wwmp 923 4 been be VBN cord-015306-us58wwmp 923 5 stopped stop VBN cord-015306-us58wwmp 923 6 for for IN cord-015306-us58wwmp 923 7 more more JJR cord-015306-us58wwmp 923 8 than than IN cord-015306-us58wwmp 923 9 one one CD cord-015306-us58wwmp 923 10 month month NN cord-015306-us58wwmp 923 11 , , , cord-015306-us58wwmp 923 12 he -PRON- PRP cord-015306-us58wwmp 923 13 seems seem VBZ cord-015306-us58wwmp 923 14 well well RB cord-015306-us58wwmp 923 15 during during IN cord-015306-us58wwmp 923 16 that that DT cord-015306-us58wwmp 923 17 period period NN cord-015306-us58wwmp 923 18 of of IN cord-015306-us58wwmp 923 19 time time NN cord-015306-us58wwmp 923 20 . . . cord-015306-us58wwmp 924 1 Methods method NNS cord-015306-us58wwmp 924 2 : : : cord-015306-us58wwmp 924 3 Children child NNS cord-015306-us58wwmp 924 4 with with IN cord-015306-us58wwmp 924 5 HSP HSP NNP cord-015306-us58wwmp 924 6 over over IN cord-015306-us58wwmp 924 7 3 3 CD cord-015306-us58wwmp 924 8 years year NNS cord-015306-us58wwmp 924 9 of of IN cord-015306-us58wwmp 924 10 age age NN cord-015306-us58wwmp 924 11 were be VBD cord-015306-us58wwmp 924 12 enrolled enrol VBN cord-015306-us58wwmp 924 13 in in IN cord-015306-us58wwmp 924 14 the the DT cord-015306-us58wwmp 924 15 study study NN cord-015306-us58wwmp 924 16 . . . cord-015306-us58wwmp 925 1 They -PRON- PRP cord-015306-us58wwmp 925 2 were be VBD cord-015306-us58wwmp 925 3 evaluated evaluate VBN cord-015306-us58wwmp 925 4 for for IN cord-015306-us58wwmp 925 5 demographic demographic JJ cord-015306-us58wwmp 925 6 , , , cord-015306-us58wwmp 925 7 anthropometric anthropometric JJ cord-015306-us58wwmp 925 8 , , , cord-015306-us58wwmp 925 9 clinical clinical JJ cord-015306-us58wwmp 925 10 and and CC cord-015306-us58wwmp 925 11 laboratory laboratory NN cord-015306-us58wwmp 925 12 data datum NNS cord-015306-us58wwmp 925 13 including include VBG cord-015306-us58wwmp 925 14 urinalysis urinalysis NN cord-015306-us58wwmp 925 15 , , , cord-015306-us58wwmp 925 16 complete complete JJ cord-015306-us58wwmp 925 17 blood blood NN cord-015306-us58wwmp 925 18 count count NN cord-015306-us58wwmp 925 19 , , , cord-015306-us58wwmp 925 20 serum serum NN cord-015306-us58wwmp 925 21 albumin albumin NN cord-015306-us58wwmp 925 22 , , , cord-015306-us58wwmp 925 23 creatinine creatinine NN cord-015306-us58wwmp 925 24 , , , cord-015306-us58wwmp 925 25 IgA IgA NNP cord-015306-us58wwmp 925 26 levels level NNS cord-015306-us58wwmp 925 27 . . . cord-015306-us58wwmp 926 1 In in IN cord-015306-us58wwmp 926 2 addition addition NN cord-015306-us58wwmp 926 3 , , , cord-015306-us58wwmp 926 4 anti anti JJ cord-015306-us58wwmp 926 5 - - JJ cord-015306-us58wwmp 926 6 tissue tissue JJ cord-015306-us58wwmp 926 7 transglutaminase transglutaminase NNP cord-015306-us58wwmp 926 8 IgA IgA NNP cord-015306-us58wwmp 926 9 ( ( -LRB- cord-015306-us58wwmp 926 10 ELISA ELISA NNP cord-015306-us58wwmp 926 11 ) ) -RRB- cord-015306-us58wwmp 926 12 , , , cord-015306-us58wwmp 926 13 anti anti JJ cord-015306-us58wwmp 926 14 - - JJ cord-015306-us58wwmp 926 15 endomysium endomysium JJ cord-015306-us58wwmp 926 16 IgA IgA NNP cord-015306-us58wwmp 926 17 ( ( -LRB- cord-015306-us58wwmp 926 18 IFAT IFAT NNP cord-015306-us58wwmp 926 19 ) ) -RRB- cord-015306-us58wwmp 926 20 , , , cord-015306-us58wwmp 926 21 antigliadin antigliadin NNP cord-015306-us58wwmp 926 22 ( ( -LRB- cord-015306-us58wwmp 926 23 GAF3X GAF3X NNP cord-015306-us58wwmp 926 24 , , , cord-015306-us58wwmp 926 25 deaminated deaminated NNP cord-015306-us58wwmp 926 26 ) ) -RRB- cord-015306-us58wwmp 926 27 IgA IgA NNP cord-015306-us58wwmp 926 28 ( ( -LRB- cord-015306-us58wwmp 926 29 IFAT IFAT NNP cord-015306-us58wwmp 926 30 ) ) -RRB- cord-015306-us58wwmp 926 31 and and CC cord-015306-us58wwmp 926 32 anti anti JJ cord-015306-us58wwmp 926 33 - - JJ cord-015306-us58wwmp 926 34 gliadin gliadin JJ cord-015306-us58wwmp 926 35 ( ( -LRB- cord-015306-us58wwmp 926 36 GAF3X GAF3X NNP cord-015306-us58wwmp 926 37 , , , cord-015306-us58wwmp 926 38 deaminated deaminated NNP cord-015306-us58wwmp 926 39 ) ) -RRB- cord-015306-us58wwmp 926 40 IgG IgG NNP cord-015306-us58wwmp 926 41 ( ( -LRB- cord-015306-us58wwmp 926 42 ELISA ELISA NNP cord-015306-us58wwmp 926 43 ) ) -RRB- cord-015306-us58wwmp 926 44 antibody antibody NN cord-015306-us58wwmp 926 45 levels level NNS cord-015306-us58wwmp 926 46 were be VBD cord-015306-us58wwmp 926 47 determined determine VBN cord-015306-us58wwmp 926 48 . . . cord-015306-us58wwmp 927 1 Seropositive seropositive JJ cord-015306-us58wwmp 927 2 patients patient NNS cord-015306-us58wwmp 927 3 were be VBD cord-015306-us58wwmp 927 4 evaluated evaluate VBN cord-015306-us58wwmp 927 5 by by IN cord-015306-us58wwmp 927 6 endoscopic endoscopic JJ cord-015306-us58wwmp 927 7 small small JJ cord-015306-us58wwmp 927 8 bowel bowel NN cord-015306-us58wwmp 927 9 biopsy biopsy NN cord-015306-us58wwmp 927 10 . . . cord-015306-us58wwmp 928 1 The the DT cord-015306-us58wwmp 928 2 rate rate NN cord-015306-us58wwmp 928 3 of of IN cord-015306-us58wwmp 928 4 CD cd NN cord-015306-us58wwmp 928 5 seropositivity seropositivity NN cord-015306-us58wwmp 928 6 in in IN cord-015306-us58wwmp 928 7 HSP HSP NNP cord-015306-us58wwmp 928 8 patients patient NNS cord-015306-us58wwmp 928 9 was be VBD cord-015306-us58wwmp 928 10 compared compare VBN cord-015306-us58wwmp 928 11 to to IN cord-015306-us58wwmp 928 12 the the DT cord-015306-us58wwmp 928 13 rate rate NN cord-015306-us58wwmp 928 14 in in IN cord-015306-us58wwmp 928 15 healthy healthy JJ cord-015306-us58wwmp 928 16 Turksih Turksih NNP cord-015306-us58wwmp 928 17 children child NNS cord-015306-us58wwmp 928 18 by by IN cord-015306-us58wwmp 928 19 the the DT cord-015306-us58wwmp 928 20 test test NN cord-015306-us58wwmp 928 21 for for IN cord-015306-us58wwmp 928 22 the the DT cord-015306-us58wwmp 928 23 statistical statistical JJ cord-015306-us58wwmp 928 24 significance significance NN cord-015306-us58wwmp 928 25 of of IN cord-015306-us58wwmp 928 26 two two CD cord-015306-us58wwmp 928 27 percentages percentage NNS cord-015306-us58wwmp 928 28 . . . cord-015306-us58wwmp 929 1 Results result NNS cord-015306-us58wwmp 929 2 : : : cord-015306-us58wwmp 930 1 Celiac celiac JJ cord-015306-us58wwmp 930 2 serology serology NN cord-015306-us58wwmp 930 3 was be VBD cord-015306-us58wwmp 930 4 evaluated evaluate VBN cord-015306-us58wwmp 930 5 in in IN cord-015306-us58wwmp 930 6 42 42 CD cord-015306-us58wwmp 930 7 children child NNS cord-015306-us58wwmp 930 8 ( ( -LRB- cord-015306-us58wwmp 930 9 25 25 CD cord-015306-us58wwmp 930 10 male male NN cord-015306-us58wwmp 930 11 , , , cord-015306-us58wwmp 930 12 mean mean VB cord-015306-us58wwmp 930 13 age age NN cord-015306-us58wwmp 930 14 11.2 11.2 CD cord-015306-us58wwmp 930 15 + + CC cord-015306-us58wwmp 931 1 /-3.6 /-3.6 NNP cord-015306-us58wwmp 931 2 years year NNS cord-015306-us58wwmp 931 3 ) ) -RRB- cord-015306-us58wwmp 931 4 with with IN cord-015306-us58wwmp 931 5 HSP HSP NNP cord-015306-us58wwmp 931 6 . . . cord-015306-us58wwmp 932 1 There there EX cord-015306-us58wwmp 932 2 was be VBD cord-015306-us58wwmp 932 3 no no DT cord-015306-us58wwmp 932 4 patient patient NN cord-015306-us58wwmp 932 5 with with IN cord-015306-us58wwmp 932 6 growth growth NN cord-015306-us58wwmp 932 7 failure failure NN cord-015306-us58wwmp 932 8 or or CC cord-015306-us58wwmp 932 9 having have VBG cord-015306-us58wwmp 932 10 symptoms symptom NNS cord-015306-us58wwmp 932 11 associated associate VBN cord-015306-us58wwmp 932 12 with with IN cord-015306-us58wwmp 932 13 CD CD NNP cord-015306-us58wwmp 932 14 like like IN cord-015306-us58wwmp 932 15 abdominal abdominal JJ cord-015306-us58wwmp 932 16 pain pain NN cord-015306-us58wwmp 932 17 , , , cord-015306-us58wwmp 932 18 abdominal abdominal JJ cord-015306-us58wwmp 932 19 distention distention NN cord-015306-us58wwmp 932 20 or or CC cord-015306-us58wwmp 932 21 diarrhea diarrhea NN cord-015306-us58wwmp 932 22 . . . cord-015306-us58wwmp 933 1 In in IN cord-015306-us58wwmp 933 2 addition addition NN cord-015306-us58wwmp 933 3 , , , cord-015306-us58wwmp 933 4 none none NN cord-015306-us58wwmp 933 5 of of IN cord-015306-us58wwmp 933 6 the the DT cord-015306-us58wwmp 933 7 patients patient NNS cord-015306-us58wwmp 933 8 had have VBD cord-015306-us58wwmp 933 9 IgA IgA NNP cord-015306-us58wwmp 933 10 deficiency deficiency NN cord-015306-us58wwmp 933 11 , , , cord-015306-us58wwmp 933 12 anemia anemia NN cord-015306-us58wwmp 933 13 or or CC cord-015306-us58wwmp 933 14 hypoalbuminemia hypoalbuminemia NN cord-015306-us58wwmp 933 15 . . . cord-015306-us58wwmp 934 1 Celiac celiac JJ cord-015306-us58wwmp 934 2 serology serology NN cord-015306-us58wwmp 934 3 was be VBD cord-015306-us58wwmp 934 4 positive positive JJ cord-015306-us58wwmp 934 5 in in IN cord-015306-us58wwmp 934 6 5 5 CD cord-015306-us58wwmp 934 7 ( ( -LRB- cord-015306-us58wwmp 934 8 12 12 CD cord-015306-us58wwmp 934 9 % % NN cord-015306-us58wwmp 934 10 ) ) -RRB- cord-015306-us58wwmp 934 11 children child NNS cord-015306-us58wwmp 934 12 . . . cord-015306-us58wwmp 935 1 Endoscopic endoscopic JJ cord-015306-us58wwmp 935 2 evaluation evaluation NN cord-015306-us58wwmp 935 3 was be VBD cord-015306-us58wwmp 935 4 performed perform VBN cord-015306-us58wwmp 935 5 in in IN cord-015306-us58wwmp 935 6 3 3 CD cord-015306-us58wwmp 935 7 patients patient NNS cord-015306-us58wwmp 935 8 and and CC cord-015306-us58wwmp 935 9 one one CD cord-015306-us58wwmp 935 10 of of IN cord-015306-us58wwmp 935 11 them -PRON- PRP cord-015306-us58wwmp 935 12 was be VBD cord-015306-us58wwmp 935 13 diagnosed diagnose VBN cord-015306-us58wwmp 935 14 as as IN cord-015306-us58wwmp 935 15 CD CD NNP cord-015306-us58wwmp 935 16 . . . cord-015306-us58wwmp 936 1 Prevalence prevalence NN cord-015306-us58wwmp 936 2 of of IN cord-015306-us58wwmp 936 3 CD cd NN cord-015306-us58wwmp 936 4 in in IN cord-015306-us58wwmp 936 5 children child NNS cord-015306-us58wwmp 936 6 with with IN cord-015306-us58wwmp 936 7 HSP HSP NNP cord-015306-us58wwmp 936 8 was be VBD cord-015306-us58wwmp 936 9 significantly significantly RB cord-015306-us58wwmp 936 10 higher high JJR cord-015306-us58wwmp 936 11 compared compare VBN cord-015306-us58wwmp 936 12 to to IN cord-015306-us58wwmp 936 13 healthy healthy JJ cord-015306-us58wwmp 936 14 Turkish turkish JJ cord-015306-us58wwmp 936 15 children child NNS cord-015306-us58wwmp 936 16 ( ( -LRB- cord-015306-us58wwmp 936 17 p<0.001 p<0.001 CD cord-015306-us58wwmp 936 18 ) ) -RRB- cord-015306-us58wwmp 936 19 . . . cord-015306-us58wwmp 937 1 Conclusions conclusion NNS cord-015306-us58wwmp 937 2 : : : cord-015306-us58wwmp 938 1 Celiac Celiac NNP cord-015306-us58wwmp 938 2 seropositivity seropositivity NN cord-015306-us58wwmp 938 3 was be VBD cord-015306-us58wwmp 938 4 12 12 CD cord-015306-us58wwmp 938 5 % % NN cord-015306-us58wwmp 938 6 in in IN cord-015306-us58wwmp 938 7 children child NNS cord-015306-us58wwmp 938 8 with with IN cord-015306-us58wwmp 938 9 HSP HSP NNP cord-015306-us58wwmp 938 10 and and CC cord-015306-us58wwmp 938 11 this this DT cord-015306-us58wwmp 938 12 rate rate NN cord-015306-us58wwmp 938 13 is be VBZ cord-015306-us58wwmp 938 14 significantly significantly RB cord-015306-us58wwmp 938 15 higher high JJR cord-015306-us58wwmp 938 16 than than IN cord-015306-us58wwmp 938 17 the the DT cord-015306-us58wwmp 938 18 rate rate NN cord-015306-us58wwmp 938 19 in in IN cord-015306-us58wwmp 938 20 healthy healthy JJ cord-015306-us58wwmp 938 21 children child NNS cord-015306-us58wwmp 938 22 . . . cord-015306-us58wwmp 939 1 Although although IN cord-015306-us58wwmp 939 2 the the DT cord-015306-us58wwmp 939 3 number number NN cord-015306-us58wwmp 939 4 of of IN cord-015306-us58wwmp 939 5 children child NNS cord-015306-us58wwmp 939 6 with with IN cord-015306-us58wwmp 939 7 HSP HSP NNP cord-015306-us58wwmp 939 8 is be VBZ cord-015306-us58wwmp 939 9 small small JJ cord-015306-us58wwmp 939 10 in in IN cord-015306-us58wwmp 939 11 this this DT cord-015306-us58wwmp 939 12 preliminary preliminary JJ cord-015306-us58wwmp 939 13 study study NN cord-015306-us58wwmp 939 14 , , , cord-015306-us58wwmp 939 15 this this DT cord-015306-us58wwmp 939 16 result result NN cord-015306-us58wwmp 939 17 suggests suggest VBZ cord-015306-us58wwmp 939 18 that that IN cord-015306-us58wwmp 939 19 celiac celiac NNS cord-015306-us58wwmp 939 20 screening screening NN cord-015306-us58wwmp 939 21 may may MD cord-015306-us58wwmp 939 22 be be VB cord-015306-us58wwmp 939 23 considered consider VBN cord-015306-us58wwmp 939 24 in in IN cord-015306-us58wwmp 939 25 children child NNS cord-015306-us58wwmp 939 26 with with IN cord-015306-us58wwmp 939 27 HSP HSP NNP cord-015306-us58wwmp 939 28 . . . cord-015306-us58wwmp 940 1 ( ( -LRB- cord-015306-us58wwmp 940 2 14 14 CD cord-015306-us58wwmp 940 3 ) ) -RRB- cord-015306-us58wwmp 940 4 groups group NNS cord-015306-us58wwmp 940 5 . . . cord-015306-us58wwmp 941 1 The the DT cord-015306-us58wwmp 941 2 glomerular glomerular JJ cord-015306-us58wwmp 941 3 and and CC cord-015306-us58wwmp 941 4 tubulointerstitial tubulointerstitial JJ cord-015306-us58wwmp 941 5 lesions lesion NNS cord-015306-us58wwmp 941 6 were be VBD cord-015306-us58wwmp 941 7 scored score VBN cord-015306-us58wwmp 941 8 by by IN cord-015306-us58wwmp 941 9 Katafuchi Katafuchi NNP cord-015306-us58wwmp 941 10 criteria criterion NNS cord-015306-us58wwmp 941 11 and and CC cord-015306-us58wwmp 941 12 Oxford Oxford NNP cord-015306-us58wwmp 941 13 classification classification NN cord-015306-us58wwmp 941 14 of of IN cord-015306-us58wwmp 941 15 IgAN IgAN NNP cord-015306-us58wwmp 941 16 , , , cord-015306-us58wwmp 941 17 respectively respectively RB cord-015306-us58wwmp 941 18 . . . cord-015306-us58wwmp 942 1 Results:1.The results:1.the UH cord-015306-us58wwmp 942 2 baseline baseline JJ cord-015306-us58wwmp 942 3 data datum NNS cord-015306-us58wwmp 942 4 of of IN cord-015306-us58wwmp 942 5 different different JJ cord-015306-us58wwmp 942 6 clincal clincal JJ cord-015306-us58wwmp 942 7 or or CC cord-015306-us58wwmp 942 8 pathological pathological JJ cord-015306-us58wwmp 942 9 groups group NNS cord-015306-us58wwmp 942 10 were be VBD cord-015306-us58wwmp 942 11 no no DT cord-015306-us58wwmp 942 12 significant significant JJ cord-015306-us58wwmp 942 13 differences difference NNS cord-015306-us58wwmp 942 14 ( ( -LRB- cord-015306-us58wwmp 942 15 P p NN cord-015306-us58wwmp 942 16 more more JJR cord-015306-us58wwmp 942 17 than than IN cord-015306-us58wwmp 942 18 0.05),but 0.05),but CD cord-015306-us58wwmp 942 19 24h 24h NNS cord-015306-us58wwmp 943 1 protienuria protienuria NNP cord-015306-us58wwmp 943 2 were be VBD cord-015306-us58wwmp 943 3 significant significant JJ cord-015306-us58wwmp 943 4 increased increase VBN cord-015306-us58wwmp 943 5 in in IN cord-015306-us58wwmp 943 6 grade grade NN cord-015306-us58wwmp 943 7 3 3 CD cord-015306-us58wwmp 943 8 and and CC cord-015306-us58wwmp 943 9 4 4 CD cord-015306-us58wwmp 943 10 groups group NNS cord-015306-us58wwmp 943 11 than than IN cord-015306-us58wwmp 943 12 grade grade NN cord-015306-us58wwmp 943 13 2 2 CD cord-015306-us58wwmp 943 14 group(P group(p XX cord-015306-us58wwmp 943 15 less less JJR cord-015306-us58wwmp 943 16 than than IN cord-015306-us58wwmp 943 17 0.05).2.According 0.05).2.accorde VBG cord-015306-us58wwmp 943 18 Katafuchi Katafuchi NNP cord-015306-us58wwmp 943 19 critiria critiria NN cord-015306-us58wwmp 943 20 , , , cord-015306-us58wwmp 944 1 the the DT cord-015306-us58wwmp 944 2 severity severity NN cord-015306-us58wwmp 944 3 scores score NNS cord-015306-us58wwmp 944 4 of of IN cord-015306-us58wwmp 944 5 glomerullar glomerullar NNP cord-015306-us58wwmp 944 6 and and CC cord-015306-us58wwmp 944 7 tubulointerstitial tubulointerstitial JJ cord-015306-us58wwmp 944 8 lesions lesion NNS cord-015306-us58wwmp 944 9 were be VBD cord-015306-us58wwmp 944 10 positively positively RB cord-015306-us58wwmp 944 11 correlated correlate VBN cord-015306-us58wwmp 944 12 with with IN cord-015306-us58wwmp 944 13 either either CC cord-015306-us58wwmp 944 14 different different JJ cord-015306-us58wwmp 944 15 clincal clincal JJ cord-015306-us58wwmp 944 16 or or CC cord-015306-us58wwmp 944 17 pathological pathological JJ cord-015306-us58wwmp 944 18 groups(P groups(P . cord-015306-us58wwmp 945 1 less less JJR cord-015306-us58wwmp 945 2 than than IN cord-015306-us58wwmp 945 3 0.01).3.According 0.01).3.accorde VBG cord-015306-us58wwmp 945 4 to to IN cord-015306-us58wwmp 945 5 Oxford Oxford NNP cord-015306-us58wwmp 945 6 classification classification NN cord-015306-us58wwmp 945 7 , , , cord-015306-us58wwmp 945 8 only only RB cord-015306-us58wwmp 945 9 the the DT cord-015306-us58wwmp 945 10 severity severity NN cord-015306-us58wwmp 945 11 scores score NNS cord-015306-us58wwmp 945 12 of of IN cord-015306-us58wwmp 945 13 mesangial mesangial JJ cord-015306-us58wwmp 945 14 hypercellularity hypercellularity NN cord-015306-us58wwmp 945 15 and and CC cord-015306-us58wwmp 945 16 segmental segmental JJ cord-015306-us58wwmp 945 17 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 945 18 / / SYM cord-015306-us58wwmp 945 19 adhension adhension NN cord-015306-us58wwmp 945 20 were be VBD cord-015306-us58wwmp 945 21 positively positively RB cord-015306-us58wwmp 945 22 correlated correlate VBN cord-015306-us58wwmp 945 23 with with IN cord-015306-us58wwmp 945 24 different different JJ cord-015306-us58wwmp 945 25 clinical clinical JJ cord-015306-us58wwmp 945 26 groups(P groups(P . cord-015306-us58wwmp 946 1 less less JJR cord-015306-us58wwmp 946 2 than than IN cord-015306-us58wwmp 946 3 0.01),but 0.01),but CD cord-015306-us58wwmp 946 4 the the DT cord-015306-us58wwmp 946 5 severity severity NN cord-015306-us58wwmp 946 6 of of IN cord-015306-us58wwmp 946 7 mesangial mesangial JJ cord-015306-us58wwmp 946 8 hypercellularity hypercellularity NN cord-015306-us58wwmp 946 9 , , , cord-015306-us58wwmp 946 10 endocapilarity endocapilarity NNP cord-015306-us58wwmp 946 11 hypercellularity hypercellularity NN cord-015306-us58wwmp 946 12 , , , cord-015306-us58wwmp 946 13 segmental segmental JJ cord-015306-us58wwmp 946 14 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 946 15 / / SYM cord-015306-us58wwmp 946 16 adhension adhension NN cord-015306-us58wwmp 946 17 , , , cord-015306-us58wwmp 946 18 tubular tubular JJ cord-015306-us58wwmp 946 19 atrophy atrophy NN cord-015306-us58wwmp 946 20 / / SYM cord-015306-us58wwmp 946 21 interstitial interstitial JJ cord-015306-us58wwmp 946 22 fibrosis fibrosis NN cord-015306-us58wwmp 946 23 and and CC cord-015306-us58wwmp 946 24 cellular cellular JJ cord-015306-us58wwmp 946 25 / / SYM cord-015306-us58wwmp 946 26 fibrocellular fibrocellular JJ cord-015306-us58wwmp 946 27 crecents crecent NNS cord-015306-us58wwmp 946 28 were be VBD cord-015306-us58wwmp 946 29 all all DT cord-015306-us58wwmp 946 30 positively positively RB cord-015306-us58wwmp 946 31 correlated correlate VBN cord-015306-us58wwmp 946 32 with with IN cord-015306-us58wwmp 946 33 different different JJ cord-015306-us58wwmp 946 34 pathological pathological JJ cord-015306-us58wwmp 946 35 groups group NNS cord-015306-us58wwmp 946 36 ( ( -LRB- cord-015306-us58wwmp 946 37 P p NN cord-015306-us58wwmp 946 38 less less JJR cord-015306-us58wwmp 946 39 than than IN cord-015306-us58wwmp 946 40 0.01 0.01 CD cord-015306-us58wwmp 946 41 ) ) -RRB- cord-015306-us58wwmp 946 42 . . . cord-015306-us58wwmp 947 1 [ [ -LRB- cord-015306-us58wwmp 947 2 1990 1990 CD cord-015306-us58wwmp 947 3 ] ] -RRB- cord-015306-us58wwmp 947 4 [ [ -LRB- cord-015306-us58wwmp 947 5 1991 1991 CD cord-015306-us58wwmp 947 6 ] ] -RRB- cord-015306-us58wwmp 948 1 [ [ -LRB- cord-015306-us58wwmp 948 2 1992 1992 CD cord-015306-us58wwmp 948 3 ] ] -RRB- cord-015306-us58wwmp 948 4 [ [ -LRB- cord-015306-us58wwmp 948 5 1993 1993 CD cord-015306-us58wwmp 948 6 ] ] -RRB- cord-015306-us58wwmp 949 1 [ [ -LRB- cord-015306-us58wwmp 949 2 1994 1994 CD cord-015306-us58wwmp 949 3 ] ] -RRB- cord-015306-us58wwmp 949 4 [ [ -LRB- cord-015306-us58wwmp 949 5 1995 1995 CD cord-015306-us58wwmp 949 6 ] ] -RRB- cord-015306-us58wwmp 950 1 [ [ -LRB- cord-015306-us58wwmp 950 2 1996 1996 CD cord-015306-us58wwmp 950 3 ] ] -RRB- cord-015306-us58wwmp 951 1 [ [ -LRB- cord-015306-us58wwmp 951 2 1997 1997 CD cord-015306-us58wwmp 951 3 ] ] -RRB- cord-015306-us58wwmp 951 4 [ [ -LRB- cord-015306-us58wwmp 951 5 1998 1998 CD cord-015306-us58wwmp 951 6 ] ] -RRB- cord-015306-us58wwmp 952 1 [ [ -LRB- cord-015306-us58wwmp 952 2 1999 1999 CD cord-015306-us58wwmp 952 3 ] ] -RRB- cord-015306-us58wwmp 952 4 [ [ -LRB- cord-015306-us58wwmp 952 5 2000 2000 CD cord-015306-us58wwmp 952 6 ] ] -RRB- cord-015306-us58wwmp 952 7 [ [ -LRB- cord-015306-us58wwmp 952 8 2001 2001 CD cord-015306-us58wwmp 952 9 ] ] -RRB- cord-015306-us58wwmp 953 1 [ [ -LRB- cord-015306-us58wwmp 953 2 2002 2002 CD cord-015306-us58wwmp 953 3 ] ] -RRB- cord-015306-us58wwmp 953 4 [ [ -LRB- cord-015306-us58wwmp 953 5 2003 2003 CD cord-015306-us58wwmp 953 6 ] ] -RRB- cord-015306-us58wwmp 953 7 [ [ -LRB- cord-015306-us58wwmp 953 8 2004 2004 CD cord-015306-us58wwmp 953 9 ] ] -RRB- cord-015306-us58wwmp 953 10 [ [ -LRB- cord-015306-us58wwmp 953 11 2005 2005 CD cord-015306-us58wwmp 953 12 ] ] -RRB- cord-015306-us58wwmp 954 1 [ [ -LRB- cord-015306-us58wwmp 954 2 2006 2006 CD cord-015306-us58wwmp 954 3 ] ] -RRB- cord-015306-us58wwmp 954 4 [ [ -LRB- cord-015306-us58wwmp 954 5 2007 2007 CD cord-015306-us58wwmp 954 6 ] ] -RRB- cord-015306-us58wwmp 954 7 [ [ -LRB- cord-015306-us58wwmp 954 8 2008 2008 CD cord-015306-us58wwmp 954 9 ] ] -RRB- cord-015306-us58wwmp 955 1 [ [ -LRB- cord-015306-us58wwmp 955 2 2009 2009 CD cord-015306-us58wwmp 955 3 ] ] -RRB- cord-015306-us58wwmp 955 4 were be VBD cord-015306-us58wwmp 955 5 evaluated evaluate VBN cord-015306-us58wwmp 955 6 retrospectively retrospectively RB cord-015306-us58wwmp 955 7 . . . cord-015306-us58wwmp 956 1 Patients patient NNS cord-015306-us58wwmp 956 2 were be VBD cord-015306-us58wwmp 956 3 analyzed analyze VBN cord-015306-us58wwmp 956 4 comparing compare VBG cord-015306-us58wwmp 956 5 those those DT cord-015306-us58wwmp 956 6 hospitalized hospitalize VBN cord-015306-us58wwmp 956 7 during during IN cord-015306-us58wwmp 956 8 the the DT cord-015306-us58wwmp 956 9 first first JJ cord-015306-us58wwmp 956 10 and and CC cord-015306-us58wwmp 956 11 the the DT cord-015306-us58wwmp 956 12 second second JJ cord-015306-us58wwmp 956 13 ten ten CD cord-015306-us58wwmp 956 14 - - HYPH cord-015306-us58wwmp 956 15 year year NN cord-015306-us58wwmp 956 16 period period NN cord-015306-us58wwmp 956 17 . . . cord-015306-us58wwmp 957 1 The the DT cord-015306-us58wwmp 957 2 long long JJ cord-015306-us58wwmp 957 3 - - HYPH cord-015306-us58wwmp 957 4 term term NN cord-015306-us58wwmp 957 5 prognosis prognosis NN cord-015306-us58wwmp 957 6 was be VBD cord-015306-us58wwmp 957 7 evaluated evaluate VBN cord-015306-us58wwmp 957 8 in in IN cord-015306-us58wwmp 957 9 60/64 60/64 CD cord-015306-us58wwmp 957 10 patients patient NNS cord-015306-us58wwmp 957 11 ( ( -LRB- cord-015306-us58wwmp 957 12 94 94 CD cord-015306-us58wwmp 957 13 % % NN cord-015306-us58wwmp 957 14 ) ) -RRB- cord-015306-us58wwmp 957 15 with with IN cord-015306-us58wwmp 957 16 HSP HSP NNP cord-015306-us58wwmp 957 17 nephritis nephritis NN cord-015306-us58wwmp 957 18 followed follow VBD cord-015306-us58wwmp 957 19 - - HYPH cord-015306-us58wwmp 957 20 up up NN cord-015306-us58wwmp 957 21 for for IN cord-015306-us58wwmp 957 22 1 1 CD cord-015306-us58wwmp 957 23 to to TO cord-015306-us58wwmp 957 24 11 11 CD cord-015306-us58wwmp 957 25 years year NNS cord-015306-us58wwmp 957 26 ( ( -LRB- cord-015306-us58wwmp 957 27 mean mean VBP cord-015306-us58wwmp 957 28 5.7±3.6 5.7±3.6 CD cord-015306-us58wwmp 957 29 years year NNS cord-015306-us58wwmp 957 30 ) ) -RRB- cord-015306-us58wwmp 957 31 based base VBN cord-015306-us58wwmp 957 32 on on IN cord-015306-us58wwmp 957 33 urine urine NN cord-015306-us58wwmp 957 34 analyses analysis NNS cord-015306-us58wwmp 957 35 , , , cord-015306-us58wwmp 957 36 serum serum NN cord-015306-us58wwmp 957 37 creatinine creatinine NN cord-015306-us58wwmp 957 38 and and CC cord-015306-us58wwmp 957 39 blood blood NN cord-015306-us58wwmp 957 40 pressure pressure NN cord-015306-us58wwmp 957 41 measurements measurement NNS cord-015306-us58wwmp 957 42 . . . cord-015306-us58wwmp 958 1 Results result NNS cord-015306-us58wwmp 958 2 : : : cord-015306-us58wwmp 959 1 Of of IN cord-015306-us58wwmp 959 2 156 156 CD cord-015306-us58wwmp 959 3 patients patient NNS cord-015306-us58wwmp 959 4 ( ( -LRB- cord-015306-us58wwmp 959 5 mean mean VB cord-015306-us58wwmp 959 6 age age NN cord-015306-us58wwmp 959 7 6.9±3.5 6.9±3.5 CD cord-015306-us58wwmp 959 8 years year NNS cord-015306-us58wwmp 959 9 , , , cord-015306-us58wwmp 959 10 range range VBP cord-015306-us58wwmp 959 11 1 1 CD cord-015306-us58wwmp 959 12 - - SYM cord-015306-us58wwmp 959 13 17 17 CD cord-015306-us58wwmp 959 14 years year NNS cord-015306-us58wwmp 959 15 , , , cord-015306-us58wwmp 959 16 M m NN cord-015306-us58wwmp 959 17 : : : cord-015306-us58wwmp 959 18 F f NN cord-015306-us58wwmp 959 19 ratio ratio NN cord-015306-us58wwmp 959 20 1.0 1.0 CD cord-015306-us58wwmp 959 21 ) ) -RRB- cord-015306-us58wwmp 959 22 with with IN cord-015306-us58wwmp 959 23 palpable palpable JJ cord-015306-us58wwmp 959 24 purpura purpura NN cord-015306-us58wwmp 959 25 ( ( -LRB- cord-015306-us58wwmp 959 26 100 100 CD cord-015306-us58wwmp 959 27 % % NN cord-015306-us58wwmp 959 28 ) ) -RRB- cord-015306-us58wwmp 959 29 , , , cord-015306-us58wwmp 959 30 other other JJ cord-015306-us58wwmp 959 31 symptoms symptom NNS cord-015306-us58wwmp 959 32 were be VBD cord-015306-us58wwmp 959 33 more more RBR cord-015306-us58wwmp 959 34 common common JJ cord-015306-us58wwmp 959 35 during during IN cord-015306-us58wwmp 959 36 the the DT cord-015306-us58wwmp 959 37 first first JJ cord-015306-us58wwmp 959 38 ten ten CD cord-015306-us58wwmp 959 39 - - HYPH cord-015306-us58wwmp 959 40 year year NN cord-015306-us58wwmp 959 41 period period NN cord-015306-us58wwmp 959 42 including include VBG cord-015306-us58wwmp 959 43 arthralgias arthralgias NNP cord-015306-us58wwmp 959 44 ( ( -LRB- cord-015306-us58wwmp 959 45 62 62 CD cord-015306-us58wwmp 959 46 % % NN cord-015306-us58wwmp 959 47 vs. vs. CC cord-015306-us58wwmp 959 48 52 52 CD cord-015306-us58wwmp 959 49 % % NN cord-015306-us58wwmp 959 50 , , , cord-015306-us58wwmp 959 51 p=0.282 p=0.282 NNP cord-015306-us58wwmp 959 52 ) ) -RRB- cord-015306-us58wwmp 959 53 , , , cord-015306-us58wwmp 959 54 gastrointestinal gastrointestinal JJ cord-015306-us58wwmp 959 55 symptoms symptom NNS cord-015306-us58wwmp 959 56 ( ( -LRB- cord-015306-us58wwmp 959 57 63 63 CD cord-015306-us58wwmp 959 58 % % NN cord-015306-us58wwmp 959 59 vs. vs. IN cord-015306-us58wwmp 959 60 44 44 CD cord-015306-us58wwmp 959 61 % % NN cord-015306-us58wwmp 959 62 , , , cord-015306-us58wwmp 959 63 p=0,018 p=0,018 NNP cord-015306-us58wwmp 959 64 ) ) -RRB- cord-015306-us58wwmp 959 65 and and CC cord-015306-us58wwmp 959 66 renal renal JJ cord-015306-us58wwmp 959 67 involvement involvement NN cord-015306-us58wwmp 959 68 ( ( -LRB- cord-015306-us58wwmp 959 69 55 55 CD cord-015306-us58wwmp 959 70 % % NN cord-015306-us58wwmp 959 71 vs. vs. IN cord-015306-us58wwmp 959 72 21 21 CD cord-015306-us58wwmp 959 73 % % NN cord-015306-us58wwmp 959 74 , , , cord-015306-us58wwmp 959 75 p=0.001 p=0.001 NNP cord-015306-us58wwmp 959 76 ) ) -RRB- cord-015306-us58wwmp 959 77 . . . cord-015306-us58wwmp 960 1 Among among IN cord-015306-us58wwmp 960 2 64 64 CD cord-015306-us58wwmp 960 3 patients patient NNS cord-015306-us58wwmp 960 4 ( ( -LRB- cord-015306-us58wwmp 960 5 41 41 CD cord-015306-us58wwmp 960 6 % % NN cord-015306-us58wwmp 960 7 ) ) -RRB- cord-015306-us58wwmp 960 8 with with IN cord-015306-us58wwmp 960 9 HSP HSP NNP cord-015306-us58wwmp 960 10 nephritis nephritis NN cord-015306-us58wwmp 960 11 , , , cord-015306-us58wwmp 960 12 42 42 CD cord-015306-us58wwmp 960 13 had have VBD cord-015306-us58wwmp 960 14 isolated isolate VBN cord-015306-us58wwmp 960 15 hematuria hematuria NN cord-015306-us58wwmp 960 16 and/or and/or CC cord-015306-us58wwmp 960 17 non non JJ cord-015306-us58wwmp 960 18 - - JJ cord-015306-us58wwmp 960 19 nephrotic nephrotic JJ cord-015306-us58wwmp 960 20 range range NN cord-015306-us58wwmp 960 21 proteinuria proteinuria NN cord-015306-us58wwmp 960 22 ( ( -LRB- cord-015306-us58wwmp 960 23 66 66 CD cord-015306-us58wwmp 960 24 % % NN cord-015306-us58wwmp 960 25 ) ) -RRB- cord-015306-us58wwmp 960 26 , , , cord-015306-us58wwmp 960 27 15 15 CD cord-015306-us58wwmp 960 28 nephritic nephritic NNP cord-015306-us58wwmp 960 29 syndrome syndrome NN cord-015306-us58wwmp 960 30 ( ( -LRB- cord-015306-us58wwmp 960 31 23 23 CD cord-015306-us58wwmp 960 32 % % NN cord-015306-us58wwmp 960 33 ) ) -RRB- cord-015306-us58wwmp 960 34 and and CC cord-015306-us58wwmp 960 35 6 6 CD cord-015306-us58wwmp 960 36 nephritic nephritic JJ cord-015306-us58wwmp 960 37 / / SYM cord-015306-us58wwmp 960 38 nephrotic nephrotic JJ cord-015306-us58wwmp 960 39 syndrome syndrome NN cord-015306-us58wwmp 960 40 ( ( -LRB- cord-015306-us58wwmp 960 41 10 10 CD cord-015306-us58wwmp 960 42 % % NN cord-015306-us58wwmp 960 43 ) ) -RRB- cord-015306-us58wwmp 960 44 . . . cord-015306-us58wwmp 961 1 Hematuria Hematuria NNP cord-015306-us58wwmp 961 2 and/or and/or CC cord-015306-us58wwmp 961 3 nonnephritic nonnephritic JJ cord-015306-us58wwmp 961 4 proteinuria proteinuria NN cord-015306-us58wwmp 961 5 was be VBD cord-015306-us58wwmp 961 6 less less RBR cord-015306-us58wwmp 961 7 common common JJ cord-015306-us58wwmp 961 8 ( ( -LRB- cord-015306-us58wwmp 961 9 p=0.0005 p=0.0005 NNP cord-015306-us58wwmp 961 10 ) ) -RRB- cord-015306-us58wwmp 961 11 in in IN cord-015306-us58wwmp 961 12 the the DT cord-015306-us58wwmp 961 13 second second JJ cord-015306-us58wwmp 961 14 tenyear tenyear NNP cord-015306-us58wwmp 961 15 period period NN cord-015306-us58wwmp 961 16 while while IN cord-015306-us58wwmp 961 17 the the DT cord-015306-us58wwmp 961 18 incidence incidence NN cord-015306-us58wwmp 961 19 of of IN cord-015306-us58wwmp 961 20 nephritic nephritic NNP cord-015306-us58wwmp 961 21 / / SYM cord-015306-us58wwmp 961 22 nephrotic nephrotic JJ cord-015306-us58wwmp 961 23 syndrome syndrome NN cord-015306-us58wwmp 961 24 was be VBD cord-015306-us58wwmp 961 25 insignificant insignificant JJ cord-015306-us58wwmp 961 26 ( ( -LRB- cord-015306-us58wwmp 961 27 p=0.807 p=0.807 NN cord-015306-us58wwmp 961 28 ) ) -RRB- cord-015306-us58wwmp 961 29 . . . cord-015306-us58wwmp 962 1 Recurrences recurrence NNS cord-015306-us58wwmp 962 2 of of IN cord-015306-us58wwmp 962 3 purpura purpura NN cord-015306-us58wwmp 962 4 had have VBD cord-015306-us58wwmp 962 5 11 11 CD cord-015306-us58wwmp 962 6 patients patient NNS cord-015306-us58wwmp 962 7 within within IN cord-015306-us58wwmp 962 8 2 2 CD cord-015306-us58wwmp 962 9 years year NNS cord-015306-us58wwmp 962 10 . . . cord-015306-us58wwmp 963 1 6 6 CD cord-015306-us58wwmp 963 2 patients patient NNS cord-015306-us58wwmp 963 3 had have VBD cord-015306-us58wwmp 963 4 renal renal JJ cord-015306-us58wwmp 963 5 biopsy biopsy NN cord-015306-us58wwmp 963 6 including include VBG cord-015306-us58wwmp 963 7 one one CD cord-015306-us58wwmp 963 8 with with IN cord-015306-us58wwmp 963 9 30 30 CD cord-015306-us58wwmp 963 10 % % NN cord-015306-us58wwmp 963 11 of of IN cord-015306-us58wwmp 963 12 crescents crescent NNS cord-015306-us58wwmp 963 13 and and CC cord-015306-us58wwmp 963 14 one one CD cord-015306-us58wwmp 963 15 another another DT cord-015306-us58wwmp 963 16 with with IN cord-015306-us58wwmp 963 17 IgA IgA NNP cord-015306-us58wwmp 963 18 nephropathy nephropathy NNP cord-015306-us58wwmp 963 19 diagnosed diagnose VBD cord-015306-us58wwmp 963 20 seven seven CD cord-015306-us58wwmp 963 21 years year NNS cord-015306-us58wwmp 963 22 after after IN cord-015306-us58wwmp 963 23 initial initial JJ cord-015306-us58wwmp 963 24 presentation presentation NN cord-015306-us58wwmp 963 25 of of IN cord-015306-us58wwmp 963 26 HSP HSP NNP cord-015306-us58wwmp 963 27 . . . cord-015306-us58wwmp 964 1 Long long JJ cord-015306-us58wwmp 964 2 - - HYPH cord-015306-us58wwmp 964 3 term term NN cord-015306-us58wwmp 964 4 prognosis prognosis NN cord-015306-us58wwmp 964 5 was be VBD cord-015306-us58wwmp 964 6 favourable favourable JJ cord-015306-us58wwmp 964 7 in in IN cord-015306-us58wwmp 964 8 most most JJS cord-015306-us58wwmp 964 9 patients patient NNS cord-015306-us58wwmp 964 10 with with IN cord-015306-us58wwmp 964 11 abnormal abnormal JJ cord-015306-us58wwmp 964 12 urine urine NN cord-015306-us58wwmp 964 13 analyses analysis NNS cord-015306-us58wwmp 964 14 in in IN cord-015306-us58wwmp 964 15 12 12 CD cord-015306-us58wwmp 964 16 ( ( -LRB- cord-015306-us58wwmp 964 17 20 20 CD cord-015306-us58wwmp 964 18 % % NN cord-015306-us58wwmp 964 19 ) ) -RRB- cord-015306-us58wwmp 964 20 , , , cord-015306-us58wwmp 964 21 in in IN cord-015306-us58wwmp 964 22 one one CD cord-015306-us58wwmp 964 23 with with IN cord-015306-us58wwmp 964 24 hypertension hypertension NN cord-015306-us58wwmp 964 25 but but CC cord-015306-us58wwmp 964 26 normal normal JJ cord-015306-us58wwmp 964 27 serum serum NN cord-015306-us58wwmp 964 28 creatinine creatinine NN cord-015306-us58wwmp 964 29 and and CC cord-015306-us58wwmp 964 30 in in IN cord-015306-us58wwmp 964 31 all all DT cord-015306-us58wwmp 964 32 with with IN cord-015306-us58wwmp 964 33 nephritic nephritic JJ cord-015306-us58wwmp 964 34 / / SYM cord-015306-us58wwmp 964 35 nephrotic nephrotic JJ cord-015306-us58wwmp 964 36 syndrome syndrome NN cord-015306-us58wwmp 964 37 at at IN cord-015306-us58wwmp 964 38 disease disease NNP cord-015306-us58wwmp 964 39 onset onset NN cord-015306-us58wwmp 964 40 . . . cord-015306-us58wwmp 965 1 Conclusion conclusion NN cord-015306-us58wwmp 965 2 : : : cord-015306-us58wwmp 966 1 clinical clinical JJ cord-015306-us58wwmp 966 2 evaluation evaluation NN cord-015306-us58wwmp 966 3 of of IN cord-015306-us58wwmp 966 4 patients patient NNS cord-015306-us58wwmp 966 5 with with IN cord-015306-us58wwmp 966 6 HSP HSP NNP cord-015306-us58wwmp 966 7 nephritis nephritis NN cord-015306-us58wwmp 966 8 treated treat VBN cord-015306-us58wwmp 966 9 at at IN cord-015306-us58wwmp 966 10 our -PRON- PRP$ cord-015306-us58wwmp 966 11 institution institution NN cord-015306-us58wwmp 966 12 showed show VBD cord-015306-us58wwmp 966 13 a a DT cord-015306-us58wwmp 966 14 good good JJ cord-015306-us58wwmp 966 15 long long JJ cord-015306-us58wwmp 966 16 - - HYPH cord-015306-us58wwmp 966 17 term term NN cord-015306-us58wwmp 966 18 prognosis prognosis NN cord-015306-us58wwmp 966 19 . . . cord-015306-us58wwmp 967 1 Urine urine NN cord-015306-us58wwmp 967 2 and and CC cord-015306-us58wwmp 967 3 blood blood NN cord-015306-us58wwmp 967 4 pressure pressure NN cord-015306-us58wwmp 967 5 abnormalities abnormality NNS cord-015306-us58wwmp 967 6 in in IN cord-015306-us58wwmp 967 7 followed follow VBN cord-015306-us58wwmp 967 8 - - HYPH cord-015306-us58wwmp 967 9 up up RP cord-015306-us58wwmp 967 10 patients patient NNS cord-015306-us58wwmp 967 11 were be VBD cord-015306-us58wwmp 967 12 associated associate VBN cord-015306-us58wwmp 967 13 with with IN cord-015306-us58wwmp 967 14 nephritis nephritis NN cord-015306-us58wwmp 967 15 at at IN cord-015306-us58wwmp 967 16 disease disease NN cord-015306-us58wwmp 967 17 onset onset NN cord-015306-us58wwmp 967 18 . . . cord-015306-us58wwmp 968 1 -up -up . cord-015306-us58wwmp 969 1 ( ( -LRB- cord-015306-us58wwmp 969 2 f f NN cord-015306-us58wwmp 969 3 - - HYPH cord-015306-us58wwmp 969 4 up up NN cord-015306-us58wwmp 969 5 ) ) -RRB- cord-015306-us58wwmp 969 6 . . . cord-015306-us58wwmp 970 1 eGFR eGFR NNP cord-015306-us58wwmp 970 2 was be VBD cord-015306-us58wwmp 970 3 estimated estimate VBN cord-015306-us58wwmp 970 4 using use VBG cord-015306-us58wwmp 970 5 Schwartz Schwartz NNP cord-015306-us58wwmp 970 6 formula formula NN cord-015306-us58wwmp 970 7 ; ; : cord-015306-us58wwmp 970 8 decline decline NN cord-015306-us58wwmp 970 9 in in IN cord-015306-us58wwmp 970 10 renal renal JJ cord-015306-us58wwmp 970 11 function function NN cord-015306-us58wwmp 970 12 was be VBD cord-015306-us58wwmp 970 13 defined define VBN cord-015306-us58wwmp 970 14 as as IN cord-015306-us58wwmp 970 15 the the DT cord-015306-us58wwmp 970 16 slope slope NN cord-015306-us58wwmp 970 17 of of IN cord-015306-us58wwmp 970 18 eGFR egfr NN cord-015306-us58wwmp 970 19 over over IN cord-015306-us58wwmp 970 20 the the DT cord-015306-us58wwmp 970 21 f f NN cord-015306-us58wwmp 970 22 - - HYPH cord-015306-us58wwmp 970 23 up up NN cord-015306-us58wwmp 970 24 . . . cord-015306-us58wwmp 971 1 Results result NNS cord-015306-us58wwmp 971 2 : : : cord-015306-us58wwmp 971 3 72 72 CD cord-015306-us58wwmp 971 4 % % NN cord-015306-us58wwmp 971 5 were be VBD cord-015306-us58wwmp 971 6 males male NNS cord-015306-us58wwmp 971 7 , , , cord-015306-us58wwmp 971 8 with with IN cord-015306-us58wwmp 971 9 mean mean JJ cord-015306-us58wwmp 971 10 age age NN cord-015306-us58wwmp 971 11 at at IN cord-015306-us58wwmp 971 12 renal renal JJ cord-015306-us58wwmp 971 13 biopsy biopsy NN cord-015306-us58wwmp 971 14 of of IN cord-015306-us58wwmp 971 15 12.7 12.7 CD cord-015306-us58wwmp 971 16 ± ± NNP cord-015306-us58wwmp 971 17 3.7 3.7 CD cord-015306-us58wwmp 971 18 y y NN cord-015306-us58wwmp 971 19 and and CC cord-015306-us58wwmp 971 20 a a DT cord-015306-us58wwmp 971 21 median median NN cord-015306-us58wwmp 971 22 f f NN cord-015306-us58wwmp 971 23 - - HYPH cord-015306-us58wwmp 971 24 up up NN cord-015306-us58wwmp 971 25 of of IN cord-015306-us58wwmp 971 26 4.7 4.7 CD cord-015306-us58wwmp 971 27 y y NN cord-015306-us58wwmp 972 1 ( ( -LRB- cord-015306-us58wwmp 972 2 IQ IQ NNP cord-015306-us58wwmp 972 3 range range NNP cord-015306-us58wwmp 972 4 2.4 2.4 CD cord-015306-us58wwmp 972 5 - - HYPH cord-015306-us58wwmp 972 6 7.8 7.8 CD cord-015306-us58wwmp 972 7 y y NN cord-015306-us58wwmp 972 8 ) ) -RRB- cord-015306-us58wwmp 972 9 ; ; : cord-015306-us58wwmp 972 10 more more JJR cord-015306-us58wwmp 972 11 than than IN cord-015306-us58wwmp 972 12 80 80 CD cord-015306-us58wwmp 972 13 % % NN cord-015306-us58wwmp 972 14 presented present VBN cord-015306-us58wwmp 972 15 with with IN cord-015306-us58wwmp 972 16 eGFR egfr NN cord-015306-us58wwmp 972 17 > > SYM cord-015306-us58wwmp 972 18 90 90 CD cord-015306-us58wwmp 972 19 ml ml NN cord-015306-us58wwmp 972 20 / / SYM cord-015306-us58wwmp 972 21 min/1.73 min/1.73 JJ cord-015306-us58wwmp 972 22 m m CD cord-015306-us58wwmp 972 23 2 2 CD cord-015306-us58wwmp 972 24 . . . cord-015306-us58wwmp 973 1 End end NN cord-015306-us58wwmp 973 2 - - HYPH cord-015306-us58wwmp 973 3 stage stage NN cord-015306-us58wwmp 973 4 renal renal JJ cord-015306-us58wwmp 973 5 disesase disesase NN cord-015306-us58wwmp 973 6 ( ( -LRB- cord-015306-us58wwmp 973 7 ESRD ESRD NNP cord-015306-us58wwmp 973 8 ) ) -RRB- cord-015306-us58wwmp 973 9 was be VBD cord-015306-us58wwmp 973 10 reached reach VBN cord-015306-us58wwmp 973 11 by by IN cord-015306-us58wwmp 973 12 4 4 CD cord-015306-us58wwmp 973 13 % % NN cord-015306-us58wwmp 973 14 of of IN cord-015306-us58wwmp 973 15 children child NNS cord-015306-us58wwmp 973 16 , , , cord-015306-us58wwmp 973 17 50 50 CD cord-015306-us58wwmp 973 18 % % NN cord-015306-us58wwmp 973 19 loss loss NN cord-015306-us58wwmp 973 20 of of IN cord-015306-us58wwmp 973 21 initial initial JJ cord-015306-us58wwmp 973 22 eGFR egfr NN cord-015306-us58wwmp 973 23 by by IN cord-015306-us58wwmp 973 24 5 5 CD cord-015306-us58wwmp 973 25 % % NN cord-015306-us58wwmp 973 26 ; ; : cord-015306-us58wwmp 973 27 7 7 CD cord-015306-us58wwmp 973 28 % % NN cord-015306-us58wwmp 973 29 reached reach VBD cord-015306-us58wwmp 973 30 the the DT cord-015306-us58wwmp 973 31 combined combined JJ cord-015306-us58wwmp 973 32 end end NN cord-015306-us58wwmp 973 33 point point NN cord-015306-us58wwmp 973 34 ( ( -LRB- cord-015306-us58wwmp 973 35 ESRD ESRD NNP cord-015306-us58wwmp 973 36 or or CC cord-015306-us58wwmp 973 37 50 50 CD cord-015306-us58wwmp 973 38 % % NN cord-015306-us58wwmp 973 39 loss loss NN cord-015306-us58wwmp 973 40 of of IN cord-015306-us58wwmp 973 41 initial initial JJ cord-015306-us58wwmp 973 42 eGFR egfr NN cord-015306-us58wwmp 973 43 ) ) -RRB- cord-015306-us58wwmp 973 44 . . . cord-015306-us58wwmp 974 1 At at IN cord-015306-us58wwmp 974 2 renal renal JJ cord-015306-us58wwmp 974 3 biopsy biopsy NN cord-015306-us58wwmp 974 4 57 57 CD cord-015306-us58wwmp 974 5 % % NN cord-015306-us58wwmp 974 6 presented present VBN cord-015306-us58wwmp 974 7 with with IN cord-015306-us58wwmp 974 8 mesangial mesangial JJ cord-015306-us58wwmp 974 9 proliferation proliferation NN cord-015306-us58wwmp 974 10 ( ( -LRB- cord-015306-us58wwmp 974 11 M1 M1 NNP cord-015306-us58wwmp 974 12 ) ) -RRB- cord-015306-us58wwmp 974 13 , , , cord-015306-us58wwmp 974 14 24 24 CD cord-015306-us58wwmp 974 15 % % NN cord-015306-us58wwmp 974 16 with with IN cord-015306-us58wwmp 974 17 endocapillary endocapillary JJ cord-015306-us58wwmp 974 18 proliferation proliferation NN cord-015306-us58wwmp 974 19 ( ( -LRB- cord-015306-us58wwmp 974 20 E1 E1 NNP cord-015306-us58wwmp 974 21 ) ) -RRB- cord-015306-us58wwmp 974 22 , , , cord-015306-us58wwmp 974 23 35 35 CD cord-015306-us58wwmp 974 24 % % NN cord-015306-us58wwmp 974 25 with with IN cord-015306-us58wwmp 974 26 segmental segmental JJ cord-015306-us58wwmp 974 27 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 974 28 ( ( -LRB- cord-015306-us58wwmp 974 29 S1 S1 NNP cord-015306-us58wwmp 974 30 ) ) -RRB- cord-015306-us58wwmp 974 31 and and CC cord-015306-us58wwmp 974 32 9 9 CD cord-015306-us58wwmp 974 33 % % NN cord-015306-us58wwmp 974 34 with with IN cord-015306-us58wwmp 974 35 tubular tubular JJ cord-015306-us58wwmp 974 36 atrophy atrophy NN cord-015306-us58wwmp 974 37 / / SYM cord-015306-us58wwmp 974 38 interstitial interstitial JJ cord-015306-us58wwmp 974 39 fibrosis fibrosis NN cord-015306-us58wwmp 975 1 ( ( -LRB- cord-015306-us58wwmp 975 2 TA TA NNP cord-015306-us58wwmp 975 3 / / SYM cord-015306-us58wwmp 975 4 IF if IN cord-015306-us58wwmp 975 5 ; ; : cord-015306-us58wwmp 975 6 T1/2 T1/2 NNP cord-015306-us58wwmp 975 7 ) ) -RRB- cord-015306-us58wwmp 975 8 . . . cord-015306-us58wwmp 976 1 Patients patient NNS cord-015306-us58wwmp 976 2 with with IN cord-015306-us58wwmp 976 3 segmental segmental JJ cord-015306-us58wwmp 976 4 sclerosis sclerosis NN cord-015306-us58wwmp 976 5 and and CC cord-015306-us58wwmp 977 1 TA TA NNP cord-015306-us58wwmp 977 2 / / SYM cord-015306-us58wwmp 977 3 IF IF NNP cord-015306-us58wwmp 977 4 showed show VBD cord-015306-us58wwmp 977 5 a a DT cord-015306-us58wwmp 977 6 significantly significantly RB cord-015306-us58wwmp 977 7 worse bad JJR cord-015306-us58wwmp 977 8 eGFR egfr JJ cord-015306-us58wwmp 977 9 slope slope NN cord-015306-us58wwmp 977 10 over over IN cord-015306-us58wwmp 977 11 the the DT cord-015306-us58wwmp 977 12 f f NNP cord-015306-us58wwmp 977 13 - - HYPH cord-015306-us58wwmp 977 14 up up RP cord-015306-us58wwmp 977 15 ( ( -LRB- cord-015306-us58wwmp 977 16 S0 S0 NNP cord-015306-us58wwmp 977 17 vs vs IN cord-015306-us58wwmp 977 18 S1 S1 NNP cord-015306-us58wwmp 977 19 p=0.04 p=0.04 NNP cord-015306-us58wwmp 977 20 ; ; : cord-015306-us58wwmp 977 21 T0 T0 NNP cord-015306-us58wwmp 977 22 vs vs IN cord-015306-us58wwmp 977 23 T1/2 T1/2 NNP cord-015306-us58wwmp 977 24 p=0.003 p=0.003 NNP cord-015306-us58wwmp 977 25 ) ) -RRB- cord-015306-us58wwmp 977 26 . . . cord-015306-us58wwmp 978 1 At at IN cord-015306-us58wwmp 978 2 univariate univariate JJ cord-015306-us58wwmp 978 3 linear linear JJ cord-015306-us58wwmp 978 4 regression regression NN cord-015306-us58wwmp 978 5 , , , cord-015306-us58wwmp 978 6 clinical clinical JJ cord-015306-us58wwmp 978 7 data datum NNS cord-015306-us58wwmp 978 8 at at IN cord-015306-us58wwmp 978 9 renal renal JJ cord-015306-us58wwmp 978 10 biopsy biopsy NN cord-015306-us58wwmp 978 11 ( ( -LRB- cord-015306-us58wwmp 978 12 eGFR egfr NN cord-015306-us58wwmp 978 13 , , , cord-015306-us58wwmp 978 14 proteinuria proteinuria NN cord-015306-us58wwmp 978 15 and and CC cord-015306-us58wwmp 978 16 MAP MAP NNP cord-015306-us58wwmp 978 17 ) ) -RRB- cord-015306-us58wwmp 978 18 were be VBD cord-015306-us58wwmp 978 19 not not RB cord-015306-us58wwmp 978 20 associated associate VBN cord-015306-us58wwmp 978 21 with with IN cord-015306-us58wwmp 978 22 renal renal JJ cord-015306-us58wwmp 978 23 function function NN cord-015306-us58wwmp 978 24 decline decline NN cord-015306-us58wwmp 978 25 , , , cord-015306-us58wwmp 978 26 while while IN cord-015306-us58wwmp 978 27 data datum NNS cord-015306-us58wwmp 978 28 at at IN cord-015306-us58wwmp 978 29 6 6 CD cord-015306-us58wwmp 978 30 - - SYM cord-015306-us58wwmp 978 31 12 12 CD cord-015306-us58wwmp 978 32 and and CC cord-015306-us58wwmp 978 33 12 12 CD cord-015306-us58wwmp 978 34 - - SYM cord-015306-us58wwmp 978 35 24 24 CD cord-015306-us58wwmp 978 36 months month NNS cord-015306-us58wwmp 978 37 and and CC cord-015306-us58wwmp 978 38 TA ta NN cord-015306-us58wwmp 978 39 - - HYPH cord-015306-us58wwmp 978 40 proteinuria proteinuria NN cord-015306-us58wwmp 978 41 and and CC cord-015306-us58wwmp 978 42 MAP MAP NNP cord-015306-us58wwmp 978 43 significantly significantly RB cord-015306-us58wwmp 978 44 predicted predict VBD cord-015306-us58wwmp 978 45 eGFR egfr JJ cord-015306-us58wwmp 978 46 slope slope NN cord-015306-us58wwmp 978 47 . . . cord-015306-us58wwmp 979 1 A a DT cord-015306-us58wwmp 979 2 multivariate multivariate JJ cord-015306-us58wwmp 979 3 linear linear JJ cord-015306-us58wwmp 979 4 regression regression NN cord-015306-us58wwmp 979 5 model model NN cord-015306-us58wwmp 979 6 ( ( -LRB- cord-015306-us58wwmp 979 7 including include VBG cord-015306-us58wwmp 979 8 proteinuria proteinuria NN cord-015306-us58wwmp 979 9 and and CC cord-015306-us58wwmp 979 10 MAP map NN cord-015306-us58wwmp 979 11 at at IN cord-015306-us58wwmp 979 12 12 12 CD cord-015306-us58wwmp 979 13 - - SYM cord-015306-us58wwmp 979 14 24 24 CD cord-015306-us58wwmp 979 15 months month NNS cord-015306-us58wwmp 979 16 together together RB cord-015306-us58wwmp 979 17 with with IN cord-015306-us58wwmp 979 18 the the DT cord-015306-us58wwmp 979 19 difference difference NN cord-015306-us58wwmp 979 20 of of IN cord-015306-us58wwmp 979 21 eGFR egfr NN cord-015306-us58wwmp 979 22 at at IN cord-015306-us58wwmp 979 23 renal renal JJ cord-015306-us58wwmp 979 24 biopsy biopsy NN cord-015306-us58wwmp 979 25 and and CC cord-015306-us58wwmp 979 26 at at IN cord-015306-us58wwmp 979 27 12 12 CD cord-015306-us58wwmp 979 28 - - SYM cord-015306-us58wwmp 979 29 24 24 CD cord-015306-us58wwmp 979 30 months month NNS cord-015306-us58wwmp 979 31 as as IN cord-015306-us58wwmp 979 32 independent independent JJ cord-015306-us58wwmp 979 33 variables variable NNS cord-015306-us58wwmp 979 34 ) ) -RRB- cord-015306-us58wwmp 979 35 performed perform VBN cord-015306-us58wwmp 979 36 well well RB cord-015306-us58wwmp 979 37 in in IN cord-015306-us58wwmp 979 38 predicting predict VBG cord-015306-us58wwmp 979 39 eGFR egfr JJ cord-015306-us58wwmp 979 40 slope slope NN cord-015306-us58wwmp 980 1 ( ( -LRB- cord-015306-us58wwmp 980 2 R r NN cord-015306-us58wwmp 980 3 2 2 CD cord-015306-us58wwmp 980 4 = = SYM cord-015306-us58wwmp 980 5 0.39 0.39 CD cord-015306-us58wwmp 980 6 ) ) -RRB- cord-015306-us58wwmp 980 7 . . . cord-015306-us58wwmp 981 1 This this DT cord-015306-us58wwmp 981 2 model model NN cord-015306-us58wwmp 981 3 was be VBD cord-015306-us58wwmp 981 4 used use VBN cord-015306-us58wwmp 981 5 to to TO cord-015306-us58wwmp 981 6 derive derive VB cord-015306-us58wwmp 981 7 a a DT cord-015306-us58wwmp 981 8 formula formula NN cord-015306-us58wwmp 981 9 able able JJ cord-015306-us58wwmp 981 10 to to TO cord-015306-us58wwmp 981 11 estimate estimate VB cord-015306-us58wwmp 981 12 eGFR egfr JJ cord-015306-us58wwmp 981 13 slope slope NN cord-015306-us58wwmp 981 14 with with IN cord-015306-us58wwmp 981 15 good good JJ cord-015306-us58wwmp 981 16 performance performance NN cord-015306-us58wwmp 981 17 ( ( -LRB- cord-015306-us58wwmp 981 18 mean mean VB cord-015306-us58wwmp 981 19 bias bias NN cord-015306-us58wwmp 981 20 between between IN cord-015306-us58wwmp 981 21 estimated estimate VBN cord-015306-us58wwmp 981 22 and and CC cord-015306-us58wwmp 981 23 really really RB cord-015306-us58wwmp 981 24 observed observe VBD cord-015306-us58wwmp 981 25 eGFR egfr JJ cord-015306-us58wwmp 981 26 slope slope NN cord-015306-us58wwmp 981 27 of of IN cord-015306-us58wwmp 981 28 0.05 0.05 CD cord-015306-us58wwmp 981 29 ± ± CD cord-015306-us58wwmp 981 30 6.6 6.6 CD cord-015306-us58wwmp 981 31 ml ml NNS cord-015306-us58wwmp 981 32 / / SYM cord-015306-us58wwmp 981 33 min/1.73 min/1.73 JJ cord-015306-us58wwmp 981 34 m m CD cord-015306-us58wwmp 981 35 2 2 CD cord-015306-us58wwmp 981 36 ) ) -RRB- cord-015306-us58wwmp 981 37 . . . cord-015306-us58wwmp 982 1 Conclusion conclusion NN cord-015306-us58wwmp 982 2 : : : cord-015306-us58wwmp 983 1 The the DT cord-015306-us58wwmp 983 2 Oxford Oxford NNP cord-015306-us58wwmp 983 3 classification classification NN cord-015306-us58wwmp 983 4 of of IN cord-015306-us58wwmp 983 5 IgAN IgAN NNP cord-015306-us58wwmp 983 6 was be VBD cord-015306-us58wwmp 983 7 well well RB cord-015306-us58wwmp 983 8 applicable applicable JJ cord-015306-us58wwmp 983 9 to to IN cord-015306-us58wwmp 983 10 this this DT cord-015306-us58wwmp 983 11 pediatric pediatric JJ cord-015306-us58wwmp 983 12 population population NN cord-015306-us58wwmp 983 13 . . . cord-015306-us58wwmp 984 1 A a DT cord-015306-us58wwmp 984 2 formula formula NN cord-015306-us58wwmp 984 3 was be VBD cord-015306-us58wwmp 984 4 developed develop VBN cord-015306-us58wwmp 984 5 that that IN cord-015306-us58wwmp 984 6 estimates estimate VBZ cord-015306-us58wwmp 984 7 renal renal JJ cord-015306-us58wwmp 984 8 function function NN cord-015306-us58wwmp 984 9 decline decline NN cord-015306-us58wwmp 984 10 over over IN cord-015306-us58wwmp 984 11 the the DT cord-015306-us58wwmp 984 12 f f NNP cord-015306-us58wwmp 984 13 - - HYPH cord-015306-us58wwmp 984 14 up up NN cord-015306-us58wwmp 984 15 based base VBN cord-015306-us58wwmp 984 16 on on IN cord-015306-us58wwmp 984 17 proteinuria proteinuria NN cord-015306-us58wwmp 984 18 , , , cord-015306-us58wwmp 984 19 MAP MAP NNP cord-015306-us58wwmp 984 20 and and CC cord-015306-us58wwmp 984 21 eGFR egfr JJ cord-015306-us58wwmp 984 22 loss loss NN cord-015306-us58wwmp 984 23 after after IN cord-015306-us58wwmp 984 24 1 1 CD cord-015306-us58wwmp 984 25 - - SYM cord-015306-us58wwmp 984 26 2 2 CD cord-015306-us58wwmp 984 27 years year NNS cord-015306-us58wwmp 984 28 of of IN cord-015306-us58wwmp 984 29 observation observation NN cord-015306-us58wwmp 984 30 , , , cord-015306-us58wwmp 984 31 which which WDT cord-015306-us58wwmp 984 32 will will MD cord-015306-us58wwmp 984 33 need need VB cord-015306-us58wwmp 984 34 a a DT cord-015306-us58wwmp 984 35 validation validation NN cord-015306-us58wwmp 984 36 on on IN cord-015306-us58wwmp 984 37 other other JJ cord-015306-us58wwmp 984 38 cohorts cohort NNS cord-015306-us58wwmp 984 39 . . . cord-015306-us58wwmp 985 1 Sixteen sixteen CD cord-015306-us58wwmp 985 2 - - HYPH cord-015306-us58wwmp 985 3 year year NN cord-015306-us58wwmp 985 4 experience experience NN cord-015306-us58wwmp 985 5 with with IN cord-015306-us58wwmp 985 6 pediatric pediatric JJ cord-015306-us58wwmp 985 7 IgA IgA NNP cord-015306-us58wwmp 985 8 nephropathy nephropathy NN cord-015306-us58wwmp 985 9 and and CC cord-015306-us58wwmp 985 10 validation validation NN cord-015306-us58wwmp 985 11 of of IN cord-015306-us58wwmp 985 12 the the DT cord-015306-us58wwmp 985 13 Oxford Oxford NNP cord-015306-us58wwmp 985 14 classification classification NN cord-015306-us58wwmp 985 15 as as IN cord-015306-us58wwmp 985 16 a a DT cord-015306-us58wwmp 985 17 risk risk NN cord-015306-us58wwmp 985 18 predictor predictor NN cord-015306-us58wwmp 985 19 ( ( -LRB- cord-015306-us58wwmp 985 20 M1 M1 NNP cord-015306-us58wwmp 985 21 ) ) -RRB- cord-015306-us58wwmp 985 22 , , , cord-015306-us58wwmp 985 23 segmental segmental JJ cord-015306-us58wwmp 985 24 sclerosis sclerosis NN cord-015306-us58wwmp 985 25 ( ( -LRB- cord-015306-us58wwmp 985 26 S1 S1 NNP cord-015306-us58wwmp 985 27 ) ) -RRB- cord-015306-us58wwmp 985 28 , , , cord-015306-us58wwmp 985 29 endocapillary endocapillary JJ cord-015306-us58wwmp 985 30 proliferation proliferation NN cord-015306-us58wwmp 985 31 ( ( -LRB- cord-015306-us58wwmp 985 32 E1 E1 NNP cord-015306-us58wwmp 985 33 ) ) -RRB- cord-015306-us58wwmp 985 34 , , , cord-015306-us58wwmp 985 35 and and CC cord-015306-us58wwmp 985 36 tubulointerstitial tubulointerstitial JJ cord-015306-us58wwmp 985 37 fibrosis fibrosis NN cord-015306-us58wwmp 985 38 ( ( -LRB- cord-015306-us58wwmp 985 39 T1 T1 NNP cord-015306-us58wwmp 985 40 or or CC cord-015306-us58wwmp 985 41 T2 T2 NNP cord-015306-us58wwmp 985 42 ) ) -RRB- cord-015306-us58wwmp 985 43 was be VBD cord-015306-us58wwmp 985 44 32 32 CD cord-015306-us58wwmp 985 45 ( ( -LRB- cord-015306-us58wwmp 985 46 35.2 35.2 CD cord-015306-us58wwmp 985 47 % % NN cord-015306-us58wwmp 985 48 ) ) -RRB- cord-015306-us58wwmp 985 49 , , , cord-015306-us58wwmp 985 50 15 15 CD cord-015306-us58wwmp 985 51 ( ( -LRB- cord-015306-us58wwmp 985 52 16.5 16.5 CD cord-015306-us58wwmp 985 53 % % NN cord-015306-us58wwmp 985 54 ) ) -RRB- cord-015306-us58wwmp 985 55 , , , cord-015306-us58wwmp 985 56 9 9 CD cord-015306-us58wwmp 985 57 ( ( -LRB- cord-015306-us58wwmp 985 58 9.9 9.9 CD cord-015306-us58wwmp 985 59 % % NN cord-015306-us58wwmp 985 60 ) ) -RRB- cord-015306-us58wwmp 985 61 , , , cord-015306-us58wwmp 985 62 and and CC cord-015306-us58wwmp 985 63 6 6 CD cord-015306-us58wwmp 985 64 ( ( -LRB- cord-015306-us58wwmp 985 65 6.6 6.6 CD cord-015306-us58wwmp 985 66 % % NN cord-015306-us58wwmp 985 67 ) ) -RRB- cord-015306-us58wwmp 985 68 , , , cord-015306-us58wwmp 985 69 respectively respectively RB cord-015306-us58wwmp 985 70 . . . cord-015306-us58wwmp 986 1 There there EX cord-015306-us58wwmp 986 2 was be VBD cord-015306-us58wwmp 986 3 no no DT cord-015306-us58wwmp 986 4 significant significant JJ cord-015306-us58wwmp 986 5 decrease decrease NN cord-015306-us58wwmp 986 6 in in IN cord-015306-us58wwmp 986 7 GFR GFR NNP cord-015306-us58wwmp 986 8 within within IN cord-015306-us58wwmp 986 9 the the DT cord-015306-us58wwmp 986 10 entire entire JJ cord-015306-us58wwmp 986 11 cohort cohort NN cord-015306-us58wwmp 986 12 . . . cord-015306-us58wwmp 987 1 However however RB cord-015306-us58wwmp 987 2 , , , cord-015306-us58wwmp 987 3 five five CD cord-015306-us58wwmp 987 4 patients patient NNS cord-015306-us58wwmp 987 5 showed show VBD cord-015306-us58wwmp 987 6 decreased decrease VBN cord-015306-us58wwmp 987 7 renal renal JJ cord-015306-us58wwmp 987 8 function function NN cord-015306-us58wwmp 987 9 , , , cord-015306-us58wwmp 987 10 and and CC cord-015306-us58wwmp 987 11 of of IN cord-015306-us58wwmp 987 12 them -PRON- PRP cord-015306-us58wwmp 987 13 , , , cord-015306-us58wwmp 987 14 two two CD cord-015306-us58wwmp 987 15 reached reach VBN cord-015306-us58wwmp 987 16 stage stage NN cord-015306-us58wwmp 987 17 III III NNP cord-015306-us58wwmp 987 18 or or CC cord-015306-us58wwmp 987 19 IV IV NNP cord-015306-us58wwmp 987 20 CKD CKD NNP cord-015306-us58wwmp 987 21 . . . cord-015306-us58wwmp 988 1 The the DT cord-015306-us58wwmp 988 2 five five CD cord-015306-us58wwmp 988 3 patients patient NNS cord-015306-us58wwmp 988 4 ' ' POS cord-015306-us58wwmp 988 5 changes change NNS cord-015306-us58wwmp 988 6 in in IN cord-015306-us58wwmp 988 7 the the DT cord-015306-us58wwmp 988 8 K K NNP cord-015306-us58wwmp 988 9 / / SYM cord-015306-us58wwmp 988 10 DOQI DOQI NNP cord-015306-us58wwmp 988 11 CKD CKD NNP cord-015306-us58wwmp 988 12 stage stage NN cord-015306-us58wwmp 988 13 were be VBD cord-015306-us58wwmp 988 14 2 2 CD cord-015306-us58wwmp 988 15 to to IN cord-015306-us58wwmp 988 16 4 4 CD cord-015306-us58wwmp 988 17 , , , cord-015306-us58wwmp 988 18 1 1 CD cord-015306-us58wwmp 988 19 to to IN cord-015306-us58wwmp 988 20 3 3 CD cord-015306-us58wwmp 988 21 , , , cord-015306-us58wwmp 988 22 1 1 CD cord-015306-us58wwmp 988 23 to to IN cord-015306-us58wwmp 988 24 2 2 CD cord-015306-us58wwmp 988 25 , , , cord-015306-us58wwmp 988 26 1 1 CD cord-015306-us58wwmp 988 27 to to IN cord-015306-us58wwmp 988 28 2 2 CD cord-015306-us58wwmp 988 29 , , , cord-015306-us58wwmp 988 30 and and CC cord-015306-us58wwmp 988 31 1 1 CD cord-015306-us58wwmp 988 32 to to IN cord-015306-us58wwmp 988 33 2 2 CD cord-015306-us58wwmp 988 34 . . . cord-015306-us58wwmp 989 1 Their -PRON- PRP$ cord-015306-us58wwmp 989 2 pathological pathological JJ cord-015306-us58wwmp 989 3 classifications classification NNS cord-015306-us58wwmp 989 4 were be VBD cord-015306-us58wwmp 989 5 Haas Haas NNP cord-015306-us58wwmp 989 6 4 4 CD cord-015306-us58wwmp 989 7 / / SYM cord-015306-us58wwmp 989 8 M1 M1 NNP cord-015306-us58wwmp 989 9 S1 S1 NNP cord-015306-us58wwmp 989 10 E0 E0 NNP cord-015306-us58wwmp 989 11 T0 T0 NNP cord-015306-us58wwmp 989 12 , , , cord-015306-us58wwmp 989 13 Haas Haas NNP cord-015306-us58wwmp 989 14 4 4 CD cord-015306-us58wwmp 989 15 / / SYM cord-015306-us58wwmp 989 16 M1 M1 NNP cord-015306-us58wwmp 989 17 S0 S0 NNP cord-015306-us58wwmp 989 18 E1 E1 NNP cord-015306-us58wwmp 989 19 T1 T1 NNP cord-015306-us58wwmp 989 20 with with IN cord-015306-us58wwmp 989 21 global global JJ cord-015306-us58wwmp 989 22 sclerosis sclerosis NN cord-015306-us58wwmp 989 23 , , , cord-015306-us58wwmp 989 24 Haas Haas NNP cord-015306-us58wwmp 989 25 1 1 CD cord-015306-us58wwmp 989 26 / / SYM cord-015306-us58wwmp 989 27 M0 m0 NN cord-015306-us58wwmp 989 28 S1 s1 NN cord-015306-us58wwmp 989 29 E0 e0 NN cord-015306-us58wwmp 989 30 T0 T0 NNP cord-015306-us58wwmp 989 31 , , , cord-015306-us58wwmp 989 32 Haas Haas NNP cord-015306-us58wwmp 989 33 1 1 CD cord-015306-us58wwmp 989 34 / / SYM cord-015306-us58wwmp 989 35 M0 m0 NN cord-015306-us58wwmp 989 36 S0 S0 NNP cord-015306-us58wwmp 989 37 E0 e0 NN cord-015306-us58wwmp 989 38 T0 T0 NNP cord-015306-us58wwmp 989 39 , , , cord-015306-us58wwmp 989 40 and and CC cord-015306-us58wwmp 989 41 Haas Haas NNP cord-015306-us58wwmp 989 42 1 1 CD cord-015306-us58wwmp 990 1 /M0 /M0 NFP cord-015306-us58wwmp 990 2 S0 S0 NNP cord-015306-us58wwmp 990 3 E0 e0 NN cord-015306-us58wwmp 990 4 T0 T0 NNP cord-015306-us58wwmp 990 5 with with IN cord-015306-us58wwmp 990 6 global global JJ cord-015306-us58wwmp 990 7 sclerosis sclerosis NN cord-015306-us58wwmp 990 8 . . . cord-015306-us58wwmp 991 1 In in IN cord-015306-us58wwmp 991 2 the the DT cord-015306-us58wwmp 991 3 Oxford Oxford NNP cord-015306-us58wwmp 991 4 classification classification NN cord-015306-us58wwmp 991 5 , , , cord-015306-us58wwmp 991 6 global global JJ cord-015306-us58wwmp 991 7 sclerosis sclerosis NN cord-015306-us58wwmp 991 8 was be VBD cord-015306-us58wwmp 991 9 the the DT cord-015306-us58wwmp 991 10 only only JJ cord-015306-us58wwmp 991 11 factor factor NN cord-015306-us58wwmp 991 12 correlated correlate VBN cord-015306-us58wwmp 991 13 with with IN cord-015306-us58wwmp 991 14 decreased decreased JJ cord-015306-us58wwmp 991 15 renal renal JJ cord-015306-us58wwmp 991 16 function function NN cord-015306-us58wwmp 991 17 , , , cord-015306-us58wwmp 991 18 whereas whereas IN cord-015306-us58wwmp 991 19 the the DT cord-015306-us58wwmp 991 20 Haas Haas NNP cord-015306-us58wwmp 991 21 classification classification NN cord-015306-us58wwmp 991 22 showed show VBD cord-015306-us58wwmp 991 23 no no DT cord-015306-us58wwmp 991 24 significant significant JJ cord-015306-us58wwmp 991 25 correlation correlation NN cord-015306-us58wwmp 991 26 with with IN cord-015306-us58wwmp 991 27 renal renal JJ cord-015306-us58wwmp 991 28 function function NN cord-015306-us58wwmp 991 29 . . . cord-015306-us58wwmp 992 1 Conclusions conclusion NNS cord-015306-us58wwmp 992 2 : : : cord-015306-us58wwmp 993 1 Global global JJ cord-015306-us58wwmp 993 2 sclerosis sclerosis NN cord-015306-us58wwmp 993 3 was be VBD cord-015306-us58wwmp 993 4 correlated correlate VBN cord-015306-us58wwmp 993 5 with with IN cord-015306-us58wwmp 993 6 decreased decreased JJ cord-015306-us58wwmp 993 7 renal renal JJ cord-015306-us58wwmp 993 8 function function NN cord-015306-us58wwmp 993 9 . . . cord-015306-us58wwmp 994 1 However however RB cord-015306-us58wwmp 994 2 , , , cord-015306-us58wwmp 994 3 in in IN cord-015306-us58wwmp 994 4 our -PRON- PRP$ cord-015306-us58wwmp 994 5 cohort cohort NN cord-015306-us58wwmp 994 6 , , , cord-015306-us58wwmp 994 7 there there EX cord-015306-us58wwmp 994 8 was be VBD cord-015306-us58wwmp 994 9 no no DT cord-015306-us58wwmp 994 10 significant significant JJ cord-015306-us58wwmp 994 11 decrease decrease NN cord-015306-us58wwmp 994 12 in in IN cord-015306-us58wwmp 994 13 renal renal JJ cord-015306-us58wwmp 994 14 function function NN cord-015306-us58wwmp 994 15 during during IN cord-015306-us58wwmp 994 16 the the DT cord-015306-us58wwmp 994 17 follow follow NN cord-015306-us58wwmp 994 18 - - HYPH cord-015306-us58wwmp 994 19 up up NN cord-015306-us58wwmp 994 20 period period NN cord-015306-us58wwmp 994 21 ( ( -LRB- cord-015306-us58wwmp 994 22 P p NN cord-015306-us58wwmp 994 23 = = SYM cord-015306-us58wwmp 994 24 0.216 0.216 CD cord-015306-us58wwmp 994 25 ) ) -RRB- cord-015306-us58wwmp 994 26 . . . cord-015306-us58wwmp 995 1 Thus thus RB cord-015306-us58wwmp 995 2 , , , cord-015306-us58wwmp 995 3 we -PRON- PRP cord-015306-us58wwmp 995 4 could could MD cord-015306-us58wwmp 995 5 not not RB cord-015306-us58wwmp 995 6 clearly clearly RB cord-015306-us58wwmp 995 7 correlate correlate VB cord-015306-us58wwmp 995 8 the the DT cord-015306-us58wwmp 995 9 Haas Haas NNP cord-015306-us58wwmp 995 10 and and CC cord-015306-us58wwmp 995 11 Oxford Oxford NNP cord-015306-us58wwmp 995 12 classifications classification NNS cord-015306-us58wwmp 995 13 with with IN cord-015306-us58wwmp 995 14 renal renal JJ cord-015306-us58wwmp 995 15 outcome outcome NN cord-015306-us58wwmp 995 16 . . . cord-015306-us58wwmp 996 1 The the DT cord-015306-us58wwmp 996 2 value value NN cord-015306-us58wwmp 996 3 of of IN cord-015306-us58wwmp 996 4 the the DT cord-015306-us58wwmp 996 5 Oxford Oxford NNP cord-015306-us58wwmp 996 6 classification classification NN cord-015306-us58wwmp 996 7 as as IN cord-015306-us58wwmp 996 8 a a DT cord-015306-us58wwmp 996 9 predictor predictor NN cord-015306-us58wwmp 996 10 of of IN cord-015306-us58wwmp 996 11 renal renal JJ cord-015306-us58wwmp 996 12 outcome outcome NN cord-015306-us58wwmp 996 13 remains remain VBZ cord-015306-us58wwmp 996 14 unclear unclear JJ cord-015306-us58wwmp 996 15 in in IN cord-015306-us58wwmp 996 16 Korean korean JJ cord-015306-us58wwmp 996 17 children child NNS cord-015306-us58wwmp 996 18 with with IN cord-015306-us58wwmp 996 19 IgA IgA NNP cord-015306-us58wwmp 996 20 nephropathy nephropathy NNP cord-015306-us58wwmp 996 21 . . . cord-015306-us58wwmp 997 1 Meng Meng NNP cord-015306-us58wwmp 997 2 - - HYPH cord-015306-us58wwmp 997 3 jie jie NNP cord-015306-us58wwmp 997 4 JIANG JIANG NNP cord-015306-us58wwmp 997 5 , , , cord-015306-us58wwmp 997 6 Xiao Xiao NNP cord-015306-us58wwmp 997 7 - - HYPH cord-015306-us58wwmp 997 8 yun yun NNP cord-015306-us58wwmp 997 9 JIANG JIANG NNP cord-015306-us58wwmp 997 10 , , , cord-015306-us58wwmp 997 11 Ying Ying NNP cord-015306-us58wwmp 997 12 MO MO NNP cord-015306-us58wwmp 997 13 , , , cord-015306-us58wwmp 997 14 Li Li NNP cord-015306-us58wwmp 997 15 - - HYPH cord-015306-us58wwmp 997 16 zhi zhi NNP cord-015306-us58wwmp 997 17 CHEN CHEN NNP cord-015306-us58wwmp 997 18 , , , cord-015306-us58wwmp 997 19 Li Li NNP cord-015306-us58wwmp 997 20 - - HYPH cord-015306-us58wwmp 997 21 ping ping NNP cord-015306-us58wwmp 997 22 RONG RONG NNP cord-015306-us58wwmp 997 23 Pediatric Pediatric NNP cord-015306-us58wwmp 997 24 , , , cord-015306-us58wwmp 997 25 The the DT cord-015306-us58wwmp 997 26 First First NNP cord-015306-us58wwmp 997 27 Affiliated Affiliated NNP cord-015306-us58wwmp 997 28 Hospital Hospital NNP cord-015306-us58wwmp 997 29 of of IN cord-015306-us58wwmp 997 30 Sun Sun NNP cord-015306-us58wwmp 997 31 Yat Yat NNP cord-015306-us58wwmp 997 32 - - HYPH cord-015306-us58wwmp 997 33 sen sen NNP cord-015306-us58wwmp 997 34 University University NNP cord-015306-us58wwmp 997 35 , , , cord-015306-us58wwmp 997 36 Guangzhou Guangzhou NNP cord-015306-us58wwmp 997 37 , , , cord-015306-us58wwmp 998 1 China China NNP cord-015306-us58wwmp 998 2 Objective Objective NNP cord-015306-us58wwmp 998 3 : : : cord-015306-us58wwmp 999 1 To to TO cord-015306-us58wwmp 999 2 analyze analyze VB cord-015306-us58wwmp 999 3 the the DT cord-015306-us58wwmp 999 4 clinicopathological clinicopathological JJ cord-015306-us58wwmp 999 5 characteristics characteristic NNS cord-015306-us58wwmp 999 6 of of IN cord-015306-us58wwmp 999 7 primary primary JJ cord-015306-us58wwmp 999 8 Immunoglobulin Immunoglobulin NNP cord-015306-us58wwmp 999 9 A A NNP cord-015306-us58wwmp 999 10 Nephropathy Nephropathy NNP cord-015306-us58wwmp 999 11 ( ( -LRB- cord-015306-us58wwmp 999 12 IgAN IgAN NNP cord-015306-us58wwmp 999 13 ) ) -RRB- cord-015306-us58wwmp 999 14 manifested manifest VBD cord-015306-us58wwmp 999 15 as as IN cord-015306-us58wwmp 999 16 macroscopic macroscopic JJ cord-015306-us58wwmp 999 17 hematuria hematuria NN cord-015306-us58wwmp 999 18 in in IN cord-015306-us58wwmp 999 19 children child NNS cord-015306-us58wwmp 999 20 . . . cord-015306-us58wwmp 1000 1 The the DT cord-015306-us58wwmp 1000 2 clinicopathological clinicopathological JJ cord-015306-us58wwmp 1000 3 characteristics characteristic NNS cord-015306-us58wwmp 1000 4 of of IN cord-015306-us58wwmp 1000 5 48 48 CD cord-015306-us58wwmp 1000 6 cases case NNS cord-015306-us58wwmp 1000 7 with with IN cord-015306-us58wwmp 1000 8 primary primary JJ cord-015306-us58wwmp 1000 9 IgAN IgAN NNP cord-015306-us58wwmp 1000 10 manifested manifest VBD cord-015306-us58wwmp 1000 11 as as IN cord-015306-us58wwmp 1000 12 macroscopic macroscopic JJ cord-015306-us58wwmp 1000 13 hematuria hematuria NN cord-015306-us58wwmp 1000 14 were be VBD cord-015306-us58wwmp 1000 15 analyzed analyze VBN cord-015306-us58wwmp 1000 16 retrospectively retrospectively RB cord-015306-us58wwmp 1000 17 . . . cord-015306-us58wwmp 1001 1 According accord VBG cord-015306-us58wwmp 1001 2 to to IN cord-015306-us58wwmp 1001 3 the the DT cord-015306-us58wwmp 1001 4 lasting lasting JJ cord-015306-us58wwmp 1001 5 time time NN cord-015306-us58wwmp 1001 6 of of IN cord-015306-us58wwmp 1001 7 macroscopic macroscopic JJ cord-015306-us58wwmp 1001 8 hematuria hematuria NN cord-015306-us58wwmp 1001 9 , , , cord-015306-us58wwmp 1001 10 15 15 CD cord-015306-us58wwmp 1001 11 cases case NNS cord-015306-us58wwmp 1001 12 were be VBD cord-015306-us58wwmp 1001 13 assigned assign VBN cord-015306-us58wwmp 1001 14 to to IN cord-015306-us58wwmp 1001 15 group group NN cord-015306-us58wwmp 1001 16 A A NNP cord-015306-us58wwmp 1001 17 ( ( -LRB- cord-015306-us58wwmp 1001 18 no no DT cord-015306-us58wwmp 1001 19 more more JJR cord-015306-us58wwmp 1001 20 than than IN cord-015306-us58wwmp 1001 21 seven seven CD cord-015306-us58wwmp 1001 22 days day NNS cord-015306-us58wwmp 1001 23 ) ) -RRB- cord-015306-us58wwmp 1001 24 and and CC cord-015306-us58wwmp 1001 25 33 33 CD cord-015306-us58wwmp 1001 26 cases case NNS cord-015306-us58wwmp 1001 27 were be VBD cord-015306-us58wwmp 1001 28 assigned assign VBN cord-015306-us58wwmp 1001 29 to to IN cord-015306-us58wwmp 1001 30 group group NN cord-015306-us58wwmp 1001 31 B B NNP cord-015306-us58wwmp 1001 32 ( ( -LRB- cord-015306-us58wwmp 1001 33 more more JJR cord-015306-us58wwmp 1001 34 than than IN cord-015306-us58wwmp 1001 35 seven seven CD cord-015306-us58wwmp 1001 36 days day NNS cord-015306-us58wwmp 1001 37 ) ) -RRB- cord-015306-us58wwmp 1001 38 . . . cord-015306-us58wwmp 1002 1 Results result NNS cord-015306-us58wwmp 1002 2 : : : cord-015306-us58wwmp 1003 1 The the DT cord-015306-us58wwmp 1003 2 manifestations manifestation NNS cord-015306-us58wwmp 1003 3 comprised comprise VBD cord-015306-us58wwmp 1003 4 : : : cord-015306-us58wwmp 1003 5 acute acute JJ cord-015306-us58wwmp 1003 6 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 1003 7 ( ( -LRB- cord-015306-us58wwmp 1003 8 40 40 CD cord-015306-us58wwmp 1003 9 % % NN cord-015306-us58wwmp 1003 10 in in IN cord-015306-us58wwmp 1003 11 group group NN cord-015306-us58wwmp 1003 12 A A NNP cord-015306-us58wwmp 1003 13 , , , cord-015306-us58wwmp 1003 14 33.3 33.3 CD cord-015306-us58wwmp 1003 15 % % NN cord-015306-us58wwmp 1003 16 in in IN cord-015306-us58wwmp 1003 17 group group NN cord-015306-us58wwmp 1003 18 B B NNP cord-015306-us58wwmp 1003 19 ) ) -RRB- cord-015306-us58wwmp 1003 20 , , , cord-015306-us58wwmp 1003 21 nephrotic nephrotic JJ cord-015306-us58wwmp 1003 22 syndrome syndrome NN cord-015306-us58wwmp 1003 23 ( ( -LRB- cord-015306-us58wwmp 1003 24 20 20 CD cord-015306-us58wwmp 1003 25 % % NN cord-015306-us58wwmp 1003 26 in in IN cord-015306-us58wwmp 1003 27 group group NN cord-015306-us58wwmp 1003 28 A A NNP cord-015306-us58wwmp 1003 29 , , , cord-015306-us58wwmp 1003 30 15.1 15.1 CD cord-015306-us58wwmp 1003 31 % % NN cord-015306-us58wwmp 1003 32 in in IN cord-015306-us58wwmp 1003 33 group group NN cord-015306-us58wwmp 1003 34 B B NNP cord-015306-us58wwmp 1003 35 ) ) -RRB- cord-015306-us58wwmp 1003 36 , , , cord-015306-us58wwmp 1003 37 hematuria hematuria NN cord-015306-us58wwmp 1003 38 and and CC cord-015306-us58wwmp 1003 39 proteinuria proteinuria NN cord-015306-us58wwmp 1003 40 ( ( -LRB- cord-015306-us58wwmp 1003 41 6.7 6.7 CD cord-015306-us58wwmp 1003 42 % % NN cord-015306-us58wwmp 1003 43 in in IN cord-015306-us58wwmp 1003 44 group group NN cord-015306-us58wwmp 1003 45 A A NNP cord-015306-us58wwmp 1003 46 , , , cord-015306-us58wwmp 1003 47 12.1 12.1 CD cord-015306-us58wwmp 1003 48 % % NN cord-015306-us58wwmp 1003 49 in in IN cord-015306-us58wwmp 1003 50 group group NN cord-015306-us58wwmp 1003 51 B B NNP cord-015306-us58wwmp 1003 52 ) ) -RRB- cord-015306-us58wwmp 1003 53 and and CC cord-015306-us58wwmp 1003 54 isolated isolate VBN cord-015306-us58wwmp 1003 55 hematuria hematuria NN cord-015306-us58wwmp 1003 56 ( ( -LRB- cord-015306-us58wwmp 1003 57 33.3 33.3 CD cord-015306-us58wwmp 1003 58 % % NN cord-015306-us58wwmp 1003 59 in in IN cord-015306-us58wwmp 1003 60 group group NN cord-015306-us58wwmp 1003 61 A A NNP cord-015306-us58wwmp 1003 62 , , , cord-015306-us58wwmp 1003 63 39.4 39.4 CD cord-015306-us58wwmp 1003 64 % % NN cord-015306-us58wwmp 1003 65 in in IN cord-015306-us58wwmp 1003 66 group group NN cord-015306-us58wwmp 1003 67 B B NNP cord-015306-us58wwmp 1003 68 ) ) -RRB- cord-015306-us58wwmp 1003 69 . . . cord-015306-us58wwmp 1003 70 20.0 20.0 CD cord-015306-us58wwmp 1003 71 % % NN cord-015306-us58wwmp 1003 72 cases case NNS cord-015306-us58wwmp 1003 73 in in IN cord-015306-us58wwmp 1003 74 group group NN cord-015306-us58wwmp 1003 75 A a NN cord-015306-us58wwmp 1003 76 and and CC cord-015306-us58wwmp 1003 77 21.2 21.2 CD cord-015306-us58wwmp 1003 78 % % NN cord-015306-us58wwmp 1003 79 cases case NNS cord-015306-us58wwmp 1003 80 in in IN cord-015306-us58wwmp 1003 81 group group NN cord-015306-us58wwmp 1003 82 B B NNP cord-015306-us58wwmp 1003 83 were be VBD cord-015306-us58wwmp 1003 84 accompanied accompany VBN cord-015306-us58wwmp 1003 85 with with IN cord-015306-us58wwmp 1003 86 abnormal abnormal JJ cord-015306-us58wwmp 1003 87 renal renal JJ cord-015306-us58wwmp 1003 88 function function NN cord-015306-us58wwmp 1003 89 . . . cord-015306-us58wwmp 1004 1 There there EX cord-015306-us58wwmp 1004 2 was be VBD cord-015306-us58wwmp 1004 3 no no DT cord-015306-us58wwmp 1004 4 significant significant JJ cord-015306-us58wwmp 1004 5 difference difference NN cord-015306-us58wwmp 1004 6 between between IN cord-015306-us58wwmp 1004 7 group group NN cord-015306-us58wwmp 1004 8 A a NN cord-015306-us58wwmp 1004 9 and and CC cord-015306-us58wwmp 1004 10 B B NNP cord-015306-us58wwmp 1004 11 ( ( -LRB- cord-015306-us58wwmp 1004 12 P>0.05 P>0.05 NNP cord-015306-us58wwmp 1004 13 ) ) -RRB- cord-015306-us58wwmp 1004 14 . . . cord-015306-us58wwmp 1005 1 The the DT cord-015306-us58wwmp 1005 2 urinary urinary JJ cord-015306-us58wwmp 1005 3 lysozyme lysozyme NNS cord-015306-us58wwmp 1005 4 or or CC cord-015306-us58wwmp 1005 5 β2-MG β2-MG NNPS cord-015306-us58wwmp 1005 6 increased increase VBD cord-015306-us58wwmp 1005 7 ( ( -LRB- cord-015306-us58wwmp 1005 8 6.7 6.7 CD cord-015306-us58wwmp 1005 9 % % NN cord-015306-us58wwmp 1005 10 in in IN cord-015306-us58wwmp 1005 11 group group NN cord-015306-us58wwmp 1005 12 A A NNP cord-015306-us58wwmp 1005 13 , , , cord-015306-us58wwmp 1005 14 30.3 30.3 CD cord-015306-us58wwmp 1005 15 % % NN cord-015306-us58wwmp 1005 16 in in IN cord-015306-us58wwmp 1005 17 group group NN cord-015306-us58wwmp 1005 18 B B NNP cord-015306-us58wwmp 1005 19 ) ) -RRB- cord-015306-us58wwmp 1005 20 . . . cord-015306-us58wwmp 1006 1 In in IN cord-015306-us58wwmp 1006 2 group group NN cord-015306-us58wwmp 1006 3 A A NNP cord-015306-us58wwmp 1006 4 , , , cord-015306-us58wwmp 1006 5 subclass subclass NN cord-015306-us58wwmp 1006 6 II II NNP cord-015306-us58wwmp 1006 7 was be VBD cord-015306-us58wwmp 1006 8 the the DT cord-015306-us58wwmp 1006 9 most most RBS cord-015306-us58wwmp 1006 10 common common JJ cord-015306-us58wwmp 1006 11 histopathological histopathological JJ cord-015306-us58wwmp 1006 12 type type NN cord-015306-us58wwmp 1006 13 ( ( -LRB- cord-015306-us58wwmp 1006 14 53.3 53.3 CD cord-015306-us58wwmp 1006 15 % % NN cord-015306-us58wwmp 1006 16 ) ) -RRB- cord-015306-us58wwmp 1006 17 , , , cord-015306-us58wwmp 1006 18 followed follow VBN cord-015306-us58wwmp 1006 19 by by IN cord-015306-us58wwmp 1006 20 III III NNP cord-015306-us58wwmp 1006 21 ( ( -LRB- cord-015306-us58wwmp 1006 22 33.3 33.3 CD cord-015306-us58wwmp 1006 23 % % NN cord-015306-us58wwmp 1006 24 ) ) -RRB- cord-015306-us58wwmp 1006 25 and and CC cord-015306-us58wwmp 1006 26 I -PRON- PRP cord-015306-us58wwmp 1006 27 ( ( -LRB- cord-015306-us58wwmp 1006 28 13.3 13.3 CD cord-015306-us58wwmp 1006 29 % % NN cord-015306-us58wwmp 1006 30 ) ) -RRB- cord-015306-us58wwmp 1006 31 while while IN cord-015306-us58wwmp 1006 32 the the DT cord-015306-us58wwmp 1006 33 predominant predominant JJ cord-015306-us58wwmp 1006 34 histopathological histopathological JJ cord-015306-us58wwmp 1006 35 types type NNS cord-015306-us58wwmp 1006 36 in in IN cord-015306-us58wwmp 1006 37 group group NN cord-015306-us58wwmp 1006 38 B B NNP cord-015306-us58wwmp 1006 39 were be VBD cord-015306-us58wwmp 1006 40 subclass subclass NN cord-015306-us58wwmp 1006 41 III III NNP cord-015306-us58wwmp 1006 42 ( ( -LRB- cord-015306-us58wwmp 1006 43 45.5 45.5 CD cord-015306-us58wwmp 1006 44 % % NN cord-015306-us58wwmp 1006 45 ) ) -RRB- cord-015306-us58wwmp 1006 46 , , , cord-015306-us58wwmp 1006 47 IV IV NNP cord-015306-us58wwmp 1006 48 ( ( -LRB- cord-015306-us58wwmp 1006 49 27.3 27.3 CD cord-015306-us58wwmp 1006 50 % % NN cord-015306-us58wwmp 1006 51 ) ) -RRB- cord-015306-us58wwmp 1006 52 , , , cord-015306-us58wwmp 1006 53 II II NNP cord-015306-us58wwmp 1006 54 ( ( -LRB- cord-015306-us58wwmp 1006 55 21.2 21.2 CD cord-015306-us58wwmp 1006 56 % % NN cord-015306-us58wwmp 1006 57 ) ) -RRB- cord-015306-us58wwmp 1006 58 and and CC cord-015306-us58wwmp 1006 59 I -PRON- PRP cord-015306-us58wwmp 1006 60 ( ( -LRB- cord-015306-us58wwmp 1006 61 6.1 6.1 CD cord-015306-us58wwmp 1006 62 % % NN cord-015306-us58wwmp 1006 63 ) ) -RRB- cord-015306-us58wwmp 1006 64 . . . cord-015306-us58wwmp 1007 1 None none NN cord-015306-us58wwmp 1007 2 in in IN cord-015306-us58wwmp 1007 3 group group NN cord-015306-us58wwmp 1007 4 A a NN cord-015306-us58wwmp 1007 5 and and CC cord-015306-us58wwmp 1007 6 15.2 15.2 CD cord-015306-us58wwmp 1007 7 % % NN cord-015306-us58wwmp 1007 8 cases case NNS cord-015306-us58wwmp 1007 9 in in IN cord-015306-us58wwmp 1007 10 group group NN cord-015306-us58wwmp 1007 11 B B NNP cord-015306-us58wwmp 1007 12 showed show VBD cord-015306-us58wwmp 1007 13 crescent crescent NN cord-015306-us58wwmp 1007 14 . . . cord-015306-us58wwmp 1008 1 Besides besides RB cord-015306-us58wwmp 1008 2 , , , cord-015306-us58wwmp 1008 3 only only RB cord-015306-us58wwmp 1008 4 one one CD cord-015306-us58wwmp 1008 5 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 1008 6 was be VBD cord-015306-us58wwmp 1008 7 in in IN cord-015306-us58wwmp 1008 8 group group NN cord-015306-us58wwmp 1008 9 A a NN cord-015306-us58wwmp 1008 10 while while NN cord-015306-us58wwmp 1008 11 8 8 CD cord-015306-us58wwmp 1008 12 ( ( -LRB- cord-015306-us58wwmp 1008 13 24.2 24.2 CD cord-015306-us58wwmp 1008 14 % % NN cord-015306-us58wwmp 1008 15 ) ) -RRB- cord-015306-us58wwmp 1008 16 cases case NNS cord-015306-us58wwmp 1008 17 of of IN cord-015306-us58wwmp 1008 18 glomerulosclerosis glomerulosclerosis NNP cord-015306-us58wwmp 1008 19 were be VBD cord-015306-us58wwmp 1008 20 in in IN cord-015306-us58wwmp 1008 21 group group NN cord-015306-us58wwmp 1009 1 B. B. NNP cord-015306-us58wwmp 1010 1 The the DT cord-015306-us58wwmp 1010 2 difference difference NN cord-015306-us58wwmp 1010 3 between between IN cord-015306-us58wwmp 1010 4 group group NN cord-015306-us58wwmp 1010 5 A a NN cord-015306-us58wwmp 1010 6 and and CC cord-015306-us58wwmp 1010 7 group group NN cord-015306-us58wwmp 1010 8 B B NNP cord-015306-us58wwmp 1010 9 was be VBD cord-015306-us58wwmp 1010 10 statistically statistically RB cord-015306-us58wwmp 1010 11 significant significant JJ cord-015306-us58wwmp 1011 1 ( ( -LRB- cord-015306-us58wwmp 1011 2 P<0.05).No p<0.05).no NN cord-015306-us58wwmp 1011 3 differences difference NNS cord-015306-us58wwmp 1011 4 were be VBD cord-015306-us58wwmp 1011 5 found find VBN cord-015306-us58wwmp 1011 6 in in IN cord-015306-us58wwmp 1011 7 balloon balloon NN cord-015306-us58wwmp 1011 8 stenosis stenosis NN cord-015306-us58wwmp 1011 9 between between IN cord-015306-us58wwmp 1011 10 group group NN cord-015306-us58wwmp 1011 11 A A NNP cord-015306-us58wwmp 1011 12 ( ( -LRB- cord-015306-us58wwmp 1011 13 6.7 6.7 CD cord-015306-us58wwmp 1011 14 % % NN cord-015306-us58wwmp 1011 15 ) ) -RRB- cord-015306-us58wwmp 1011 16 and and CC cord-015306-us58wwmp 1011 17 group group NN cord-015306-us58wwmp 1011 18 B B NNP cord-015306-us58wwmp 1011 19 ( ( -LRB- cord-015306-us58wwmp 1011 20 12.1 12.1 CD cord-015306-us58wwmp 1011 21 % % NN cord-015306-us58wwmp 1011 22 ) ) -RRB- cord-015306-us58wwmp 1011 23 , , , cord-015306-us58wwmp 1011 24 as as RB cord-015306-us58wwmp 1011 25 well well RB cord-015306-us58wwmp 1011 26 as as IN cord-015306-us58wwmp 1011 27 the the DT cord-015306-us58wwmp 1011 28 renal renal JJ cord-015306-us58wwmp 1011 29 tubular tubular JJ cord-015306-us58wwmp 1011 30 and and CC cord-015306-us58wwmp 1011 31 interstitial interstitial JJ cord-015306-us58wwmp 1011 32 damage damage NN cord-015306-us58wwmp 1011 33 ( ( -LRB- cord-015306-us58wwmp 1011 34 33.3 33.3 CD cord-015306-us58wwmp 1011 35 % % NN cord-015306-us58wwmp 1011 36 in in IN cord-015306-us58wwmp 1011 37 group group NN cord-015306-us58wwmp 1011 38 A A NNP cord-015306-us58wwmp 1011 39 , , , cord-015306-us58wwmp 1011 40 39.4 39.4 CD cord-015306-us58wwmp 1011 41 % % NN cord-015306-us58wwmp 1011 42 in in IN cord-015306-us58wwmp 1011 43 group group NN cord-015306-us58wwmp 1011 44 B B NNP cord-015306-us58wwmp 1011 45 ) ) -RRB- cord-015306-us58wwmp 1011 46 . . . cord-015306-us58wwmp 1012 1 46.7 46.7 CD cord-015306-us58wwmp 1012 2 % % NN cord-015306-us58wwmp 1012 3 cases case NNS cord-015306-us58wwmp 1012 4 in in IN cord-015306-us58wwmp 1012 5 group group NN cord-015306-us58wwmp 1012 6 A a NN cord-015306-us58wwmp 1012 7 and and CC cord-015306-us58wwmp 1012 8 60.1 60.1 CD cord-015306-us58wwmp 1012 9 % % NN cord-015306-us58wwmp 1012 10 cases case NNS cord-015306-us58wwmp 1012 11 in in IN cord-015306-us58wwmp 1012 12 group group NN cord-015306-us58wwmp 1012 13 B B NNP cord-015306-us58wwmp 1012 14 were be VBD cord-015306-us58wwmp 1012 15 found find VBN cord-015306-us58wwmp 1012 16 with with IN cord-015306-us58wwmp 1012 17 simple simple JJ cord-015306-us58wwmp 1012 18 IgA IgA NNP cord-015306-us58wwmp 1012 19 deposition deposition NN cord-015306-us58wwmp 1012 20 in in IN cord-015306-us58wwmp 1012 21 mesangial mesangial JJ cord-015306-us58wwmp 1012 22 area area NN cord-015306-us58wwmp 1012 23 . . . cord-015306-us58wwmp 1013 1 There there EX cord-015306-us58wwmp 1013 2 was be VBD cord-015306-us58wwmp 1013 3 no no DT cord-015306-us58wwmp 1013 4 significant significant JJ cord-015306-us58wwmp 1013 5 difference difference NN cord-015306-us58wwmp 1013 6 between between IN cord-015306-us58wwmp 1013 7 group group NN cord-015306-us58wwmp 1013 8 A a NN cord-015306-us58wwmp 1013 9 and and CC cord-015306-us58wwmp 1013 10 group group NN cord-015306-us58wwmp 1013 11 B b NN cord-015306-us58wwmp 1013 12 ( ( -LRB- cord-015306-us58wwmp 1013 13 P>0.05 P>0.05 NNP cord-015306-us58wwmp 1013 14 ) ) -RRB- cord-015306-us58wwmp 1013 15 . . . cord-015306-us58wwmp 1014 1 The the DT cord-015306-us58wwmp 1014 2 children child NNS cord-015306-us58wwmp 1014 3 with with IN cord-015306-us58wwmp 1014 4 primary primary JJ cord-015306-us58wwmp 1014 5 IgAN IgAN NNP cord-015306-us58wwmp 1014 6 manifested manifest VBD cord-015306-us58wwmp 1014 7 as as IN cord-015306-us58wwmp 1014 8 macroscopic macroscopic JJ cord-015306-us58wwmp 1014 9 hematuria hematuria NN cord-015306-us58wwmp 1014 10 lasting last VBG cord-015306-us58wwmp 1014 11 for for IN cord-015306-us58wwmp 1014 12 more more JJR cord-015306-us58wwmp 1014 13 than than IN cord-015306-us58wwmp 1014 14 seven seven CD cord-015306-us58wwmp 1014 15 days day NNS cord-015306-us58wwmp 1014 16 are be VBP cord-015306-us58wwmp 1014 17 easily easily RB cord-015306-us58wwmp 1014 18 appearing appear VBG cord-015306-us58wwmp 1014 19 renal renal JJ cord-015306-us58wwmp 1014 20 tubular tubular JJ cord-015306-us58wwmp 1014 21 damage damage NN cord-015306-us58wwmp 1014 22 , , , cord-015306-us58wwmp 1014 23 crescent crescent NN cord-015306-us58wwmp 1014 24 formation formation NN cord-015306-us58wwmp 1014 25 and and CC cord-015306-us58wwmp 1014 26 glomerulosclerosis glomerulosclerosis NNP cord-015306-us58wwmp 1014 27 . . . cord-015306-us58wwmp 1015 1 Subclass Subclass NNP cord-015306-us58wwmp 1015 2 III III NNP cord-015306-us58wwmp 1015 3 and and CC cord-015306-us58wwmp 1015 4 IV IV NNP cord-015306-us58wwmp 1015 5 are be VBP cord-015306-us58wwmp 1015 6 the the DT cord-015306-us58wwmp 1015 7 most most RBS cord-015306-us58wwmp 1015 8 common common JJ cord-015306-us58wwmp 1015 9 histopathological histopathological JJ cord-015306-us58wwmp 1015 10 types type NNS cord-015306-us58wwmp 1015 11 . . . cord-015306-us58wwmp 1016 1 A a DT cord-015306-us58wwmp 1016 2 case case NN cord-015306-us58wwmp 1016 3 report report NN cord-015306-us58wwmp 1016 4 of of IN cord-015306-us58wwmp 1016 5 IgA IgA NNP cord-015306-us58wwmp 1016 6 nephropathy nephropathy NNP cord-015306-us58wwmp 1016 7 accompanying accompany VBG cord-015306-us58wwmp 1016 8 Crohn Crohn NNP cord-015306-us58wwmp 1016 9 's 's POS cord-015306-us58wwmp 1016 10 disease disease NN cord-015306-us58wwmp 1016 11 Akihiko Akihiko NNP cord-015306-us58wwmp 1016 12 Shirasu Shirasu NNP cord-015306-us58wwmp 1016 13 1 1 CD cord-015306-us58wwmp 1016 14 , , , cord-015306-us58wwmp 1016 15 Akira Akira NNP cord-015306-us58wwmp 1016 16 Ashida Ashida NNP cord-015306-us58wwmp 1016 17 2 2 CD cord-015306-us58wwmp 1016 18 , , , cord-015306-us58wwmp 1016 19 Hideki Hideki NNP cord-015306-us58wwmp 1016 20 Matsumura Matsumura NNP cord-015306-us58wwmp 1016 21 2 2 CD cord-015306-us58wwmp 1016 22 , , , cord-015306-us58wwmp 1016 23 Hyogo Hyogo NNP cord-015306-us58wwmp 1016 24 Nakakura Nakakura NNP cord-015306-us58wwmp 1016 25 2 2 CD cord-015306-us58wwmp 1016 26 , , , cord-015306-us58wwmp 1016 27 Tomoki Tomoki NNP cord-015306-us58wwmp 1016 28 Aomatsu Aomatsu NNP cord-015306-us58wwmp 1016 29 2 2 CD cord-015306-us58wwmp 1016 30 , , , cord-015306-us58wwmp 1016 31 Atsushi Atsushi NNP cord-015306-us58wwmp 1016 32 Yoden Yoden NNP cord-015306-us58wwmp 1016 33 2 2 CD cord-015306-us58wwmp 1016 34 , , , cord-015306-us58wwmp 1016 35 Motoshi Motoshi NNP cord-015306-us58wwmp 1016 36 Hattori Hattori NNP cord-015306-us58wwmp 1016 37 3 3 CD cord-015306-us58wwmp 1016 38 , , , cord-015306-us58wwmp 1016 39 Hiroshi Hiroshi NNP cord-015306-us58wwmp 1016 40 Tamai Tamai NNP cord-015306-us58wwmp 1016 41 2 2 CD cord-015306-us58wwmp 1016 42 , , , cord-015306-us58wwmp 1016 43 1 1 CD cord-015306-us58wwmp 1016 44 Pediatrics Pediatrics NNP cord-015306-us58wwmp 1016 45 , , , cord-015306-us58wwmp 1016 46 Hirakata Hirakata NNP cord-015306-us58wwmp 1016 47 City City NNP cord-015306-us58wwmp 1016 48 Hospital Hospital NNP cord-015306-us58wwmp 1016 49 , , , cord-015306-us58wwmp 1016 50 Hirakata Hirakata NNP cord-015306-us58wwmp 1016 51 , , , cord-015306-us58wwmp 1016 52 Japan Japan NNP cord-015306-us58wwmp 1016 53 2 2 CD cord-015306-us58wwmp 1016 54 Pediatrics Pediatrics NNP cord-015306-us58wwmp 1016 55 , , , cord-015306-us58wwmp 1016 56 Osaka Osaka NNP cord-015306-us58wwmp 1016 57 Medical Medical NNP cord-015306-us58wwmp 1016 58 College College NNP cord-015306-us58wwmp 1016 59 , , , cord-015306-us58wwmp 1016 60 Takatsuki Takatsuki NNP cord-015306-us58wwmp 1016 61 , , , cord-015306-us58wwmp 1017 1 Japan Japan NNP cord-015306-us58wwmp 1017 2 3 3 CD cord-015306-us58wwmp 1017 3 Pediatric Pediatric NNP cord-015306-us58wwmp 1017 4 Nephrology Nephrology NNP cord-015306-us58wwmp 1017 5 , , , cord-015306-us58wwmp 1017 6 Tokyo Tokyo NNP cord-015306-us58wwmp 1017 7 Wemen Wemen NNP cord-015306-us58wwmp 1017 8 's 's POS cord-015306-us58wwmp 1017 9 Medical Medical NNP cord-015306-us58wwmp 1017 10 University University NNP cord-015306-us58wwmp 1017 11 , , , cord-015306-us58wwmp 1017 12 Tokyo Tokyo NNP cord-015306-us58wwmp 1017 13 , , , cord-015306-us58wwmp 1017 14 Japan Japan NNP cord-015306-us58wwmp 1017 15 There there EX cord-015306-us58wwmp 1017 16 have have VBP cord-015306-us58wwmp 1017 17 been be VBN cord-015306-us58wwmp 1017 18 several several JJ cord-015306-us58wwmp 1017 19 reports report NNS cord-015306-us58wwmp 1017 20 of of IN cord-015306-us58wwmp 1017 21 IgA IgA NNP cord-015306-us58wwmp 1017 22 nephropathy nephropathy NNP cord-015306-us58wwmp 1017 23 accompanying accompany VBG cord-015306-us58wwmp 1017 24 Crohn Crohn NNP cord-015306-us58wwmp 1017 25 's 's POS cord-015306-us58wwmp 1017 26 disease disease NN cord-015306-us58wwmp 1017 27 in in IN cord-015306-us58wwmp 1017 28 which which WDT cord-015306-us58wwmp 1017 29 the the DT cord-015306-us58wwmp 1017 30 clinical clinical JJ cord-015306-us58wwmp 1017 31 course course NN cord-015306-us58wwmp 1017 32 of of IN cord-015306-us58wwmp 1017 33 the the DT cord-015306-us58wwmp 1017 34 two two CD cord-015306-us58wwmp 1017 35 diseases disease NNS cord-015306-us58wwmp 1017 36 was be VBD cord-015306-us58wwmp 1017 37 linked link VBN cord-015306-us58wwmp 1017 38 . . . cord-015306-us58wwmp 1018 1 We -PRON- PRP cord-015306-us58wwmp 1018 2 recently recently RB cord-015306-us58wwmp 1018 3 experienced experience VBD cord-015306-us58wwmp 1018 4 a a DT cord-015306-us58wwmp 1018 5 case case NN cord-015306-us58wwmp 1018 6 of of IN cord-015306-us58wwmp 1018 7 IgA IgA NNP cord-015306-us58wwmp 1018 8 nephropathy nephropathy NN cord-015306-us58wwmp 1018 9 with with IN cord-015306-us58wwmp 1018 10 deterioration deterioration NN cord-015306-us58wwmp 1018 11 of of IN cord-015306-us58wwmp 1018 12 renal renal JJ cord-015306-us58wwmp 1018 13 function function NN cord-015306-us58wwmp 1018 14 complicated complicate VBN cord-015306-us58wwmp 1018 15 by by IN cord-015306-us58wwmp 1018 16 Crohn Crohn NNP cord-015306-us58wwmp 1018 17 's 's POS cord-015306-us58wwmp 1018 18 disease disease NN cord-015306-us58wwmp 1018 19 . . . cord-015306-us58wwmp 1019 1 A a DT cord-015306-us58wwmp 1019 2 15- 15- CD cord-015306-us58wwmp 1019 3 year year NN cord-015306-us58wwmp 1019 4 - - HYPH cord-015306-us58wwmp 1019 5 old old JJ cord-015306-us58wwmp 1019 6 boy boy NN cord-015306-us58wwmp 1019 7 diagnosed diagnose VBN cord-015306-us58wwmp 1019 8 as as IN cord-015306-us58wwmp 1019 9 having have VBG cord-015306-us58wwmp 1019 10 Crohn Crohn NNP cord-015306-us58wwmp 1019 11 's 's POS cord-015306-us58wwmp 1019 12 disease disease NN cord-015306-us58wwmp 1019 13 underwent undergo VBD cord-015306-us58wwmp 1019 14 total total JJ cord-015306-us58wwmp 1019 15 colectomy colectomy NN cord-015306-us58wwmp 1019 16 at at IN cord-015306-us58wwmp 1019 17 the the DT cord-015306-us58wwmp 1019 18 age age NN cord-015306-us58wwmp 1019 19 of of IN cord-015306-us58wwmp 1019 20 7 7 CD cord-015306-us58wwmp 1019 21 years year NNS cord-015306-us58wwmp 1019 22 . . . cord-015306-us58wwmp 1020 1 The the DT cord-015306-us58wwmp 1020 2 patient patient NN cord-015306-us58wwmp 1020 3 was be VBD cord-015306-us58wwmp 1020 4 referred refer VBN cord-015306-us58wwmp 1020 5 to to IN cord-015306-us58wwmp 1020 6 pediatric pediatric JJ cord-015306-us58wwmp 1020 7 gastroenterology gastroenterology NN cord-015306-us58wwmp 1020 8 unit unit NN cord-015306-us58wwmp 1020 9 at at IN cord-015306-us58wwmp 1020 10 the the DT cord-015306-us58wwmp 1020 11 age age NN cord-015306-us58wwmp 1020 12 of of IN cord-015306-us58wwmp 1020 13 13 13 CD cord-015306-us58wwmp 1020 14 , , , cord-015306-us58wwmp 1020 15 and and CC cord-015306-us58wwmp 1020 16 thereafter thereafter RB cord-015306-us58wwmp 1020 17 maintained maintain VBD cord-015306-us58wwmp 1020 18 a a DT cord-015306-us58wwmp 1020 19 state state NN cord-015306-us58wwmp 1020 20 of of IN cord-015306-us58wwmp 1020 21 remission remission NN cord-015306-us58wwmp 1020 22 form form NN cord-015306-us58wwmp 1020 23 Crohn Crohn NNP cord-015306-us58wwmp 1020 24 's 's POS cord-015306-us58wwmp 1020 25 disease disease NN cord-015306-us58wwmp 1020 26 while while IN cord-015306-us58wwmp 1020 27 receiving receive VBG cord-015306-us58wwmp 1020 28 5-aminosalicylic 5-aminosalicylic CD cord-015306-us58wwmp 1020 29 acid acid NN cord-015306-us58wwmp 1020 30 ( ( -LRB- cord-015306-us58wwmp 1020 31 5-ASA 5-asa CD cord-015306-us58wwmp 1020 32 ) ) -RRB- cord-015306-us58wwmp 1020 33 . . . cord-015306-us58wwmp 1021 1 Two two CD cord-015306-us58wwmp 1021 2 months month NNS cord-015306-us58wwmp 1021 3 prior prior RB cord-015306-us58wwmp 1021 4 to to IN cord-015306-us58wwmp 1021 5 referral referral NN cord-015306-us58wwmp 1021 6 to to IN cord-015306-us58wwmp 1021 7 our -PRON- PRP$ cord-015306-us58wwmp 1021 8 pediatric pediatric JJ cord-015306-us58wwmp 1021 9 nephrology nephrology NN cord-015306-us58wwmp 1021 10 unit unit NN cord-015306-us58wwmp 1021 11 , , , cord-015306-us58wwmp 1021 12 when when WRB cord-015306-us58wwmp 1021 13 the the DT cord-015306-us58wwmp 1021 14 patient patient NN cord-015306-us58wwmp 1021 15 was be VBD cord-015306-us58wwmp 1021 16 15 15 CD cord-015306-us58wwmp 1021 17 years year NNS cord-015306-us58wwmp 1021 18 old old JJ cord-015306-us58wwmp 1021 19 , , , cord-015306-us58wwmp 1021 20 a a DT cord-015306-us58wwmp 1021 21 school school NN cord-015306-us58wwmp 1021 22 health health NN cord-015306-us58wwmp 1021 23 examination examination NN cord-015306-us58wwmp 1021 24 had have VBD cord-015306-us58wwmp 1021 25 revealed reveal VBN cord-015306-us58wwmp 1021 26 microscopic microscopic JJ cord-015306-us58wwmp 1021 27 hematuria hematuria NN cord-015306-us58wwmp 1021 28 and and CC cord-015306-us58wwmp 1021 29 mild mild JJ cord-015306-us58wwmp 1021 30 proteinuria proteinuria NN cord-015306-us58wwmp 1021 31 . . . cord-015306-us58wwmp 1022 1 At at IN cord-015306-us58wwmp 1022 2 that that DT cord-015306-us58wwmp 1022 3 time time NN cord-015306-us58wwmp 1022 4 , , , cord-015306-us58wwmp 1022 5 laboratory laboratory NN cord-015306-us58wwmp 1022 6 tests test NNS cord-015306-us58wwmp 1022 7 suggested suggest VBD cord-015306-us58wwmp 1022 8 deterioration deterioration NN cord-015306-us58wwmp 1022 9 of of IN cord-015306-us58wwmp 1022 10 renal renal JJ cord-015306-us58wwmp 1022 11 function function NN cord-015306-us58wwmp 1022 12 . . . cord-015306-us58wwmp 1023 1 Renal renal JJ cord-015306-us58wwmp 1023 2 biopsy biopsy NN cord-015306-us58wwmp 1023 3 was be VBD cord-015306-us58wwmp 1023 4 performed perform VBN cord-015306-us58wwmp 1023 5 and and CC cord-015306-us58wwmp 1023 6 histological histological JJ cord-015306-us58wwmp 1023 7 examination examination NN cord-015306-us58wwmp 1023 8 by by IN cord-015306-us58wwmp 1023 9 light light JJ cord-015306-us58wwmp 1023 10 microscopy microscopy NNS cord-015306-us58wwmp 1023 11 demonstrated demonstrate VBD cord-015306-us58wwmp 1023 12 focal focal JJ cord-015306-us58wwmp 1023 13 segmental segmental JJ cord-015306-us58wwmp 1023 14 mesangial mesangial JJ cord-015306-us58wwmp 1023 15 proliferation proliferation NN cord-015306-us58wwmp 1023 16 and and CC cord-015306-us58wwmp 1023 17 moderate moderate JJ cord-015306-us58wwmp 1023 18 tubule tubule NN cord-015306-us58wwmp 1023 19 atrophy atrophy NN cord-015306-us58wwmp 1023 20 with with IN cord-015306-us58wwmp 1023 21 a a DT cord-015306-us58wwmp 1023 22 diffuse diffuse JJ cord-015306-us58wwmp 1023 23 interstitial interstitial JJ cord-015306-us58wwmp 1023 24 inflammatory inflammatory JJ cord-015306-us58wwmp 1023 25 infiltrate infiltrate NN cord-015306-us58wwmp 1023 26 consisting consist VBG cord-015306-us58wwmp 1023 27 predominantly predominantly RB cord-015306-us58wwmp 1023 28 of of IN cord-015306-us58wwmp 1023 29 lymphocytes lymphocyte NNS cord-015306-us58wwmp 1023 30 . . . cord-015306-us58wwmp 1024 1 Immunofluorescence immunofluorescence NN cord-015306-us58wwmp 1024 2 assays assay NNS cord-015306-us58wwmp 1024 3 revealed reveal VBD cord-015306-us58wwmp 1024 4 2 2 CD cord-015306-us58wwmp 1024 5 + + CC cord-015306-us58wwmp 1024 6 diffuse diffuse VB cord-015306-us58wwmp 1024 7 granular granular JJ cord-015306-us58wwmp 1024 8 staining staining NN cord-015306-us58wwmp 1024 9 for for IN cord-015306-us58wwmp 1024 10 IgA IgA NNP cord-015306-us58wwmp 1024 11 and and CC cord-015306-us58wwmp 1024 12 1 1 CD cord-015306-us58wwmp 1024 13 + + SYM cord-015306-us58wwmp 1024 14 staining stain VBG cord-015306-us58wwmp 1024 15 for for IN cord-015306-us58wwmp 1024 16 C3 C3 NNP cord-015306-us58wwmp 1024 17 in in IN cord-015306-us58wwmp 1024 18 the the DT cord-015306-us58wwmp 1024 19 mesangium mesangium NN cord-015306-us58wwmp 1024 20 . . . cord-015306-us58wwmp 1025 1 Therefore therefore RB cord-015306-us58wwmp 1025 2 , , , cord-015306-us58wwmp 1025 3 the the DT cord-015306-us58wwmp 1025 4 patient patient NN cord-015306-us58wwmp 1025 5 was be VBD cord-015306-us58wwmp 1025 6 diagnosed diagnose VBN cord-015306-us58wwmp 1025 7 as as IN cord-015306-us58wwmp 1025 8 having have VBG cord-015306-us58wwmp 1025 9 IgA IgA NNP cord-015306-us58wwmp 1025 10 nephropathy nephropathy NN cord-015306-us58wwmp 1025 11 and and CC cord-015306-us58wwmp 1025 12 chronic chronic JJ cord-015306-us58wwmp 1025 13 interstitial interstitial JJ cord-015306-us58wwmp 1025 14 nephritis nephritis NN cord-015306-us58wwmp 1025 15 . . . cord-015306-us58wwmp 1026 1 The the DT cord-015306-us58wwmp 1026 2 5-ASA 5-asa CD cord-015306-us58wwmp 1026 3 therapy therapy NN cord-015306-us58wwmp 1026 4 was be VBD cord-015306-us58wwmp 1026 5 stopped stop VBN cord-015306-us58wwmp 1026 6 considering consider VBG cord-015306-us58wwmp 1026 7 the the DT cord-015306-us58wwmp 1026 8 possibility possibility NN cord-015306-us58wwmp 1026 9 that that IN cord-015306-us58wwmp 1026 10 it -PRON- PRP cord-015306-us58wwmp 1026 11 had have VBD cord-015306-us58wwmp 1026 12 induced induce VBN cord-015306-us58wwmp 1026 13 interstitial interstitial JJ cord-015306-us58wwmp 1026 14 nephritis nephritis NN cord-015306-us58wwmp 1026 15 . . . cord-015306-us58wwmp 1027 1 The the DT cord-015306-us58wwmp 1027 2 renal renal JJ cord-015306-us58wwmp 1027 3 function function NN cord-015306-us58wwmp 1027 4 of of IN cord-015306-us58wwmp 1027 5 the the DT cord-015306-us58wwmp 1027 6 patient patient NN cord-015306-us58wwmp 1027 7 has have VBZ cord-015306-us58wwmp 1027 8 since since RB cord-015306-us58wwmp 1027 9 remained remain VBN cord-015306-us58wwmp 1027 10 quiescent quiescent JJ cord-015306-us58wwmp 1027 11 for for IN cord-015306-us58wwmp 1027 12 7 7 CD cord-015306-us58wwmp 1027 13 months month NNS cord-015306-us58wwmp 1027 14 . . . cord-015306-us58wwmp 1028 1 Patients patient NNS cord-015306-us58wwmp 1028 2 with with IN cord-015306-us58wwmp 1028 3 Crohn Crohn NNP cord-015306-us58wwmp 1028 4 's 's POS cord-015306-us58wwmp 1028 5 disease disease NN cord-015306-us58wwmp 1028 6 who who WP cord-015306-us58wwmp 1028 7 present present VBP cord-015306-us58wwmp 1028 8 with with IN cord-015306-us58wwmp 1028 9 abnormal abnormal JJ cord-015306-us58wwmp 1028 10 urinalysis urinalysis NN cord-015306-us58wwmp 1028 11 findings finding NNS cord-015306-us58wwmp 1028 12 commonly commonly RB cord-015306-us58wwmp 1028 13 have have VBP cord-015306-us58wwmp 1028 14 urological urological JJ cord-015306-us58wwmp 1028 15 complications complication NNS cord-015306-us58wwmp 1028 16 , , , cord-015306-us58wwmp 1028 17 such such JJ cord-015306-us58wwmp 1028 18 as as IN cord-015306-us58wwmp 1028 19 urolithiasis urolithiasis NN cord-015306-us58wwmp 1028 20 and and CC cord-015306-us58wwmp 1028 21 urinary urinary JJ cord-015306-us58wwmp 1028 22 tract tract JJ cord-015306-us58wwmp 1028 23 infections infection NNS cord-015306-us58wwmp 1028 24 . . . cord-015306-us58wwmp 1029 1 However however RB cord-015306-us58wwmp 1029 2 , , , cord-015306-us58wwmp 1029 3 the the DT cord-015306-us58wwmp 1029 4 possibility possibility NN cord-015306-us58wwmp 1029 5 of of IN cord-015306-us58wwmp 1029 6 renal renal JJ cord-015306-us58wwmp 1029 7 parenchymal parenchymal NN cord-015306-us58wwmp 1029 8 disease disease NN cord-015306-us58wwmp 1029 9 including include VBG cord-015306-us58wwmp 1029 10 IgA IgA NNP cord-015306-us58wwmp 1029 11 nephropathy nephropathy NNP cord-015306-us58wwmp 1029 12 should should MD cord-015306-us58wwmp 1029 13 also also RB cord-015306-us58wwmp 1029 14 be be VB cord-015306-us58wwmp 1029 15 considered consider VBN cord-015306-us58wwmp 1029 16 , , , cord-015306-us58wwmp 1029 17 even even RB cord-015306-us58wwmp 1029 18 if if IN cord-015306-us58wwmp 1029 19 there there EX cord-015306-us58wwmp 1029 20 is be VBZ cord-015306-us58wwmp 1029 21 no no DT cord-015306-us58wwmp 1029 22 apparent apparent JJ cord-015306-us58wwmp 1029 23 aggregative aggregative JJ cord-015306-us58wwmp 1029 24 linkage linkage NN cord-015306-us58wwmp 1029 25 of of IN cord-015306-us58wwmp 1029 26 urinalysis urinalysis NN cord-015306-us58wwmp 1029 27 findings finding NNS cord-015306-us58wwmp 1029 28 with with IN cord-015306-us58wwmp 1029 29 gastrointestinal gastrointestinal JJ cord-015306-us58wwmp 1029 30 symptoms symptom NNS cord-015306-us58wwmp 1029 31 of of IN cord-015306-us58wwmp 1029 32 Crohn Crohn NNP cord-015306-us58wwmp 1029 33 's 's POS cord-015306-us58wwmp 1029 34 disease disease NN cord-015306-us58wwmp 1029 35 . . . cord-015306-us58wwmp 1030 1 The the DT cord-015306-us58wwmp 1030 2 duration duration NN cord-015306-us58wwmp 1030 3 of of IN cord-015306-us58wwmp 1030 4 heavy heavy JJ cord-015306-us58wwmp 1030 5 proteinuria proteinuria NN cord-015306-us58wwmp 1030 6 determined determine VBN cord-015306-us58wwmp 1030 7 long long JJ cord-015306-us58wwmp 1030 8 - - HYPH cord-015306-us58wwmp 1030 9 term term NN cord-015306-us58wwmp 1030 10 outcome outcome NN cord-015306-us58wwmp 1030 11 of of IN cord-015306-us58wwmp 1030 12 Henoch Henoch NNP cord-015306-us58wwmp 1030 13 - - HYPH cord-015306-us58wwmp 1030 14 Schönlein Schönlein NNP cord-015306-us58wwmp 1030 15 purpura purpura NN cord-015306-us58wwmp 1030 16 nephritis nephritis NN cord-015306-us58wwmp 1030 17 in in IN cord-015306-us58wwmp 1030 18 children child NNS cord-015306-us58wwmp 1030 19 Results result NNS cord-015306-us58wwmp 1030 20 : : : cord-015306-us58wwmp 1031 1 Among among IN cord-015306-us58wwmp 1031 2 the the DT cord-015306-us58wwmp 1031 3 9 9 CD cord-015306-us58wwmp 1031 4 patients patient NNS cord-015306-us58wwmp 1031 5 , , , cord-015306-us58wwmp 1031 6 7 7 CD cord-015306-us58wwmp 1031 7 ( ( -LRB- cord-015306-us58wwmp 1031 8 77.78 77.78 CD cord-015306-us58wwmp 1031 9 % % NN cord-015306-us58wwmp 1031 10 ) ) -RRB- cord-015306-us58wwmp 1031 11 cases case NNS cord-015306-us58wwmp 1031 12 presented present VBN cord-015306-us58wwmp 1031 13 with with IN cord-015306-us58wwmp 1031 14 hematuria hematuria NN cord-015306-us58wwmp 1031 15 and and CC cord-015306-us58wwmp 1031 16 nephrotic nephrotic JJ cord-015306-us58wwmp 1031 17 syndrome syndrome NN cord-015306-us58wwmp 1031 18 ( ( -LRB- cord-015306-us58wwmp 1031 19 NS NS NNP cord-015306-us58wwmp 1031 20 ) ) -RRB- cord-015306-us58wwmp 1031 21 ; ; : cord-015306-us58wwmp 1031 22 1 1 CD cord-015306-us58wwmp 1031 23 ( ( -LRB- cord-015306-us58wwmp 1031 24 11.11 11.11 CD cord-015306-us58wwmp 1031 25 % % NN cord-015306-us58wwmp 1031 26 ) ) -RRB- cord-015306-us58wwmp 1031 27 with with IN cord-015306-us58wwmp 1031 28 hematuria hematuria NN cord-015306-us58wwmp 1031 29 and and CC cord-015306-us58wwmp 1031 30 nephrotic nephrotic JJ cord-015306-us58wwmp 1031 31 range range NN cord-015306-us58wwmp 1031 32 proteinuria proteinuria NN cord-015306-us58wwmp 1031 33 ( ( -LRB- cord-015306-us58wwmp 1031 34 > > XX cord-015306-us58wwmp 1031 35 50mg 50mg CD cord-015306-us58wwmp 1031 36 / / SYM cord-015306-us58wwmp 1031 37 kg/24h kg/24h NNP cord-015306-us58wwmp 1031 38 ) ) -RRB- cord-015306-us58wwmp 1031 39 ; ; : cord-015306-us58wwmp 1031 40 1 1 CD cord-015306-us58wwmp 1031 41 ( ( -LRB- cord-015306-us58wwmp 1031 42 11.11 11.11 CD cord-015306-us58wwmp 1031 43 % % NN cord-015306-us58wwmp 1031 44 ) ) -RRB- cord-015306-us58wwmp 1031 45 with with IN cord-015306-us58wwmp 1031 46 hematuria hematuria NN cord-015306-us58wwmp 1031 47 and and CC cord-015306-us58wwmp 1031 48 moderate moderate JJ cord-015306-us58wwmp 1031 49 proteinuria proteinuria NN cord-015306-us58wwmp 1031 50 ( ( -LRB- cord-015306-us58wwmp 1031 51 25~50mg 25~50mg CD cord-015306-us58wwmp 1031 52 / / SYM cord-015306-us58wwmp 1031 53 kg/24h kg/24h '' cord-015306-us58wwmp 1031 54 ) ) -RRB- cord-015306-us58wwmp 1031 55 . . . cord-015306-us58wwmp 1032 1 The the DT cord-015306-us58wwmp 1032 2 typical typical JJ cord-015306-us58wwmp 1032 3 pathological pathological JJ cord-015306-us58wwmp 1032 4 features feature NNS cord-015306-us58wwmp 1032 5 , , , cord-015306-us58wwmp 1032 6 such such JJ cord-015306-us58wwmp 1032 7 as as IN cord-015306-us58wwmp 1032 8 the the DT cord-015306-us58wwmp 1032 9 diffuse diffuse JJ cord-015306-us58wwmp 1032 10 glomerular glomerular JJ cord-015306-us58wwmp 1032 11 mesangial mesangial JJ cord-015306-us58wwmp 1032 12 and and CC cord-015306-us58wwmp 1032 13 endocapillary endocapillary JJ cord-015306-us58wwmp 1032 14 proliferation proliferation NN cord-015306-us58wwmp 1032 15 , , , cord-015306-us58wwmp 1032 16 mesangial mesangial JJ cord-015306-us58wwmp 1032 17 interposition interposition NN cord-015306-us58wwmp 1032 18 , , , cord-015306-us58wwmp 1032 19 and and CC cord-015306-us58wwmp 1032 20 double double JJ cord-015306-us58wwmp 1032 21 contour contour NN cord-015306-us58wwmp 1032 22 formation formation NN cord-015306-us58wwmp 1032 23 , , , cord-015306-us58wwmp 1032 24 were be VBD cord-015306-us58wwmp 1032 25 shown show VBN cord-015306-us58wwmp 1032 26 in in IN cord-015306-us58wwmp 1032 27 all all DT cord-015306-us58wwmp 1032 28 specimens specimen NNS cord-015306-us58wwmp 1032 29 . . . cord-015306-us58wwmp 1033 1 Moreover moreover RB cord-015306-us58wwmp 1033 2 , , , cord-015306-us58wwmp 1033 3 the the DT cord-015306-us58wwmp 1033 4 podocyte podocyte JJ cord-015306-us58wwmp 1033 5 hypertrophy hypertrophy NN cord-015306-us58wwmp 1033 6 , , , cord-015306-us58wwmp 1033 7 shedding shed VBG cord-015306-us58wwmp 1033 8 , , , cord-015306-us58wwmp 1033 9 and and CC cord-015306-us58wwmp 1033 10 cytoplasmic cytoplasmic JJ cord-015306-us58wwmp 1033 11 absorption absorption NN cord-015306-us58wwmp 1033 12 dropletswere dropletswere RB cord-015306-us58wwmp 1033 13 also also RB cord-015306-us58wwmp 1033 14 observed observe VBD cord-015306-us58wwmp 1033 15 in in IN cord-015306-us58wwmp 1033 16 most most JJS cord-015306-us58wwmp 1033 17 specimens specimen NNS cord-015306-us58wwmp 1033 18 under under IN cord-015306-us58wwmp 1033 19 light light JJ cord-015306-us58wwmp 1033 20 microscopy microscopy NNS cord-015306-us58wwmp 1033 21 . . . cord-015306-us58wwmp 1034 1 The the DT cord-015306-us58wwmp 1034 2 percentage percentage NN cord-015306-us58wwmp 1034 3 of of IN cord-015306-us58wwmp 1034 4 small small JJ cord-015306-us58wwmp 1034 5 cellular cellular JJ cord-015306-us58wwmp 1034 6 crescents crescent NNS cord-015306-us58wwmp 1034 7 varied varied JJ cord-015306-us58wwmp 1034 8 from from IN cord-015306-us58wwmp 1034 9 4.25 4.25 CD cord-015306-us58wwmp 1034 10 - - SYM cord-015306-us58wwmp 1034 11 25 25 CD cord-015306-us58wwmp 1034 12 % % NN cord-015306-us58wwmp 1034 13 . . . cord-015306-us58wwmp 1035 1 9 9 CD cord-015306-us58wwmp 1035 2 patients patient NNS cord-015306-us58wwmp 1035 3 were be VBD cord-015306-us58wwmp 1035 4 followed follow VBN cord-015306-us58wwmp 1035 5 up up RP cord-015306-us58wwmp 1035 6 for for IN cord-015306-us58wwmp 1035 7 2 2 CD cord-015306-us58wwmp 1035 8 to to TO cord-015306-us58wwmp 1035 9 4 4 CD cord-015306-us58wwmp 1035 10 years year NNS cord-015306-us58wwmp 1035 11 , , , cord-015306-us58wwmp 1035 12 and and CC cord-015306-us58wwmp 1035 13 all all DT cord-015306-us58wwmp 1035 14 had have VBD cord-015306-us58wwmp 1035 15 recovered recover VBN cord-015306-us58wwmp 1035 16 . . . cord-015306-us58wwmp 1036 1 Conclusion conclusion NN cord-015306-us58wwmp 1036 2 : : : cord-015306-us58wwmp 1037 1 The the DT cord-015306-us58wwmp 1037 2 predominant predominant JJ cord-015306-us58wwmp 1037 3 clinical clinical JJ cord-015306-us58wwmp 1037 4 manifestation manifestation NN cord-015306-us58wwmp 1037 5 of of IN cord-015306-us58wwmp 1037 6 ISKDC ISKDC NNP cord-015306-us58wwmp 1037 7 grade grade NN cord-015306-us58wwmp 1037 8 VI VI NNP cord-015306-us58wwmp 1037 9 HSPN HSPN NNP cord-015306-us58wwmp 1037 10 in in IN cord-015306-us58wwmp 1037 11 children child NNS cord-015306-us58wwmp 1038 1 was be VBD cord-015306-us58wwmp 1038 2 NS NS NNP cord-015306-us58wwmp 1038 3 accompanying accompany VBG cord-015306-us58wwmp 1038 4 with with IN cord-015306-us58wwmp 1038 5 hematuria hematuria NN cord-015306-us58wwmp 1038 6 . . . cord-015306-us58wwmp 1039 1 The the DT cord-015306-us58wwmp 1039 2 well well JJ cord-015306-us58wwmp 1039 3 outcome outcome NN cord-015306-us58wwmp 1039 4 might may MD cord-015306-us58wwmp 1039 5 be be VB cord-015306-us58wwmp 1039 6 associated associate VBN cord-015306-us58wwmp 1039 7 with with IN cord-015306-us58wwmp 1039 8 the the DT cord-015306-us58wwmp 1039 9 prompt prompt JJ cord-015306-us58wwmp 1039 10 use use NN cord-015306-us58wwmp 1039 11 of of IN cord-015306-us58wwmp 1039 12 steroids steroid NNS cord-015306-us58wwmp 1039 13 and/or and/or CC cord-015306-us58wwmp 1039 14 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 1039 15 drugs drug NNS cord-015306-us58wwmp 1039 16 at at IN cord-015306-us58wwmp 1039 17 the the DT cord-015306-us58wwmp 1039 18 onset onset NN cord-015306-us58wwmp 1039 19 of of IN cord-015306-us58wwmp 1039 20 ISKDC ISKDC NNP cord-015306-us58wwmp 1039 21 grade grade NN cord-015306-us58wwmp 1039 22 VI VI NNP cord-015306-us58wwmp 1039 23 HSPN HSPN NNP cord-015306-us58wwmp 1039 24 with with IN cord-015306-us58wwmp 1039 25 very very RB cord-015306-us58wwmp 1039 26 mild mild JJ cord-015306-us58wwmp 1039 27 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 1039 28 and and CC cord-015306-us58wwmp 1039 29 tubulointerstitial tubulointerstitial JJ cord-015306-us58wwmp 1039 30 lesion lesion NN cord-015306-us58wwmp 1039 31 . . . cord-015306-us58wwmp 1040 1 In in IN cord-015306-us58wwmp 1040 2 our -PRON- PRP$ cord-015306-us58wwmp 1040 3 future future JJ cord-015306-us58wwmp 1040 4 study study NN cord-015306-us58wwmp 1040 5 , , , cord-015306-us58wwmp 1040 6 all all DT cord-015306-us58wwmp 1040 7 patients patient NNS cord-015306-us58wwmp 1040 8 should should MD cord-015306-us58wwmp 1040 9 be be VB cord-015306-us58wwmp 1040 10 followed follow VBN cord-015306-us58wwmp 1040 11 for for IN cord-015306-us58wwmp 1040 12 five five CD cord-015306-us58wwmp 1040 13 or or CC cord-015306-us58wwmp 1040 14 ten ten CD cord-015306-us58wwmp 1040 15 years year NNS cord-015306-us58wwmp 1040 16 , , , cord-015306-us58wwmp 1040 17 and and CC cord-015306-us58wwmp 1040 18 more more JJR cord-015306-us58wwmp 1040 19 specimens specimen NNS cord-015306-us58wwmp 1040 20 should should MD cord-015306-us58wwmp 1040 21 be be VB cord-015306-us58wwmp 1040 22 observed observe VBN cord-015306-us58wwmp 1040 23 under under IN cord-015306-us58wwmp 1040 24 electron electron NN cord-015306-us58wwmp 1040 25 microscope microscope NN cord-015306-us58wwmp 1040 26 to to TO cord-015306-us58wwmp 1040 27 investigate investigate VB cord-015306-us58wwmp 1040 28 whether whether IN cord-015306-us58wwmp 1040 29 the the DT cord-015306-us58wwmp 1040 30 podocyte podocyte JJ cord-015306-us58wwmp 1040 31 lesions lesion NNS cord-015306-us58wwmp 1040 32 of of IN cord-015306-us58wwmp 1040 33 ISKDC ISKDC NNP cord-015306-us58wwmp 1040 34 grade grade NN cord-015306-us58wwmp 1040 35 VIHSPN VIHSPN NNP cord-015306-us58wwmp 1040 36 should should MD cord-015306-us58wwmp 1040 37 be be VB cord-015306-us58wwmp 1040 38 taken take VBN cord-015306-us58wwmp 1040 39 into into IN cord-015306-us58wwmp 1040 40 account account NN cord-015306-us58wwmp 1040 41 in in IN cord-015306-us58wwmp 1040 42 the the DT cord-015306-us58wwmp 1040 43 clinical clinical JJ cord-015306-us58wwmp 1040 44 pathological pathological JJ cord-015306-us58wwmp 1040 45 report report NN cord-015306-us58wwmp 1040 46 and and CC cord-015306-us58wwmp 1040 47 a a DT cord-015306-us58wwmp 1040 48 future future JJ cord-015306-us58wwmp 1040 49 new new JJ cord-015306-us58wwmp 1040 50 histologic histologic JJ cord-015306-us58wwmp 1040 51 classification classification NN cord-015306-us58wwmp 1040 52 of of IN cord-015306-us58wwmp 1040 53 HSPN HSPN NNP cord-015306-us58wwmp 1040 54 . . . cord-015306-us58wwmp 1041 1 Objective objective NN cord-015306-us58wwmp 1041 2 : : : cord-015306-us58wwmp 1042 1 The the DT cord-015306-us58wwmp 1042 2 aim aim NN cord-015306-us58wwmp 1042 3 of of IN cord-015306-us58wwmp 1042 4 the the DT cord-015306-us58wwmp 1042 5 study study NN cord-015306-us58wwmp 1042 6 was be VBD cord-015306-us58wwmp 1042 7 to to TO cord-015306-us58wwmp 1042 8 assess assess VB cord-015306-us58wwmp 1042 9 efficacy efficacy NN cord-015306-us58wwmp 1042 10 of of IN cord-015306-us58wwmp 1042 11 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 1042 12 treatment treatment NN cord-015306-us58wwmp 1042 13 in in IN cord-015306-us58wwmp 1042 14 children child NNS cord-015306-us58wwmp 1042 15 with with IN cord-015306-us58wwmp 1042 16 IgA IgA NNP cord-015306-us58wwmp 1042 17 nephropathy nephropathy NNP cord-015306-us58wwmp 1042 18 ( ( -LRB- cord-015306-us58wwmp 1042 19 IgAN IgAN NNP cord-015306-us58wwmp 1042 20 ) ) -RRB- cord-015306-us58wwmp 1042 21 and and CC cord-015306-us58wwmp 1042 22 Henoch Henoch NNP cord-015306-us58wwmp 1042 23 - - HYPH cord-015306-us58wwmp 1042 24 Schoenlein Schoenlein NNP cord-015306-us58wwmp 1042 25 nephritis nephritis NN cord-015306-us58wwmp 1042 26 ( ( -LRB- cord-015306-us58wwmp 1042 27 HSN HSN NNP cord-015306-us58wwmp 1042 28 ) ) -RRB- cord-015306-us58wwmp 1042 29 based base VBN cord-015306-us58wwmp 1042 30 on on IN cord-015306-us58wwmp 1042 31 clinical clinical JJ cord-015306-us58wwmp 1042 32 manifestation manifestation NN cord-015306-us58wwmp 1042 33 and and CC cord-015306-us58wwmp 1042 34 histopathological histopathological JJ cord-015306-us58wwmp 1042 35 Oxford Oxford NNP cord-015306-us58wwmp 1042 36 ( ( -LRB- cord-015306-us58wwmp 1042 37 O O NNP cord-015306-us58wwmp 1042 38 - - HYPH cord-015306-us58wwmp 1042 39 C C NNP cord-015306-us58wwmp 1042 40 ) ) -RRB- cord-015306-us58wwmp 1042 41 and and CC cord-015306-us58wwmp 1042 42 WHO who WP cord-015306-us58wwmp 1042 43 ( ( -LRB- cord-015306-us58wwmp 1042 44 WHO who WP cord-015306-us58wwmp 1042 45 - - HYPH cord-015306-us58wwmp 1042 46 C C NNP cord-015306-us58wwmp 1042 47 ) ) -RRB- cord-015306-us58wwmp 1042 48 classifications classification NNS cord-015306-us58wwmp 1042 49 . . . cord-015306-us58wwmp 1043 1 The the DT cord-015306-us58wwmp 1043 2 study study NN cord-015306-us58wwmp 1043 3 group group NN cord-015306-us58wwmp 1043 4 consisted consist VBD cord-015306-us58wwmp 1043 5 of of IN cord-015306-us58wwmp 1043 6 18 18 CD cord-015306-us58wwmp 1043 7 children child NNS cord-015306-us58wwmp 1043 8 with with IN cord-015306-us58wwmp 1043 9 IgAN-9 igan-9 ADD cord-015306-us58wwmp 1043 10 and and CC cord-015306-us58wwmp 1043 11 HSN HSN NNP cord-015306-us58wwmp 1043 12 -9 -9 NNP cord-015306-us58wwmp 1043 13 , , , cord-015306-us58wwmp 1043 14 ( ( -LRB- cord-015306-us58wwmp 1043 15 mean mean UH cord-015306-us58wwmp 1043 16 age age NN cord-015306-us58wwmp 1043 17 10.44 10.44 CD cord-015306-us58wwmp 1043 18 ±3.94 ±3.94 JJ cord-015306-us58wwmp 1043 19 years year NNS cord-015306-us58wwmp 1043 20 ) ) -RRB- cord-015306-us58wwmp 1043 21 , , , cord-015306-us58wwmp 1043 22 treated treat VBN cord-015306-us58wwmp 1043 23 with with IN cord-015306-us58wwmp 1043 24 azathioprine azathioprine NN cord-015306-us58wwmp 1043 25 ( ( -LRB- cord-015306-us58wwmp 1043 26 AZA AZA NNP cord-015306-us58wwmp 1043 27 ) ) -RRB- cord-015306-us58wwmp 1044 1 2 2 CD cord-015306-us58wwmp 1044 2 mg mg NNP cord-015306-us58wwmp 1044 3 / / SYM cord-015306-us58wwmp 1044 4 kg kg NNP cord-015306-us58wwmp 1044 5 / / SYM cord-015306-us58wwmp 1044 6 day day NN cord-015306-us58wwmp 1045 1 -12 -12 CD cord-015306-us58wwmp 1045 2 months month NNS cord-015306-us58wwmp 1045 3 with with IN cord-015306-us58wwmp 1045 4 Prednison Prednison NNP cord-015306-us58wwmp 1045 5 ( ( -LRB- cord-015306-us58wwmp 1045 6 Pred Pred NNP cord-015306-us58wwmp 1045 7 ) ) -RRB- cord-015306-us58wwmp 1045 8 2mg 2mg NNP cord-015306-us58wwmp 1045 9 / / SYM cord-015306-us58wwmp 1045 10 kg kg NN cord-015306-us58wwmp 1045 11 / / SYM cord-015306-us58wwmp 1045 12 day day NN cord-015306-us58wwmp 1045 13 ( ( -LRB- cord-015306-us58wwmp 1045 14 nephrotic nephrotic JJ cord-015306-us58wwmp 1045 15 syndrome syndrome NN cord-015306-us58wwmp 1045 16 - - HYPH cord-015306-us58wwmp 1045 17 NS NS NNP cord-015306-us58wwmp 1045 18 ) ) -RRB- cord-015306-us58wwmp 1046 1 , , , cord-015306-us58wwmp 1046 2 1mg 1mg NNP cord-015306-us58wwmp 1046 3 / / SYM cord-015306-us58wwmp 1046 4 kg kg NNP cord-015306-us58wwmp 1046 5 / / SYM cord-015306-us58wwmp 1046 6 day day NN cord-015306-us58wwmp 1046 7 ( ( -LRB- cord-015306-us58wwmp 1046 8 nephritic nephritic NNP cord-015306-us58wwmp 1046 9 syndrome syndrome NNP cord-015306-us58wwmp 1046 10 -NPS -NPS NNP cord-015306-us58wwmp 1046 11 ) ) -RRB- cord-015306-us58wwmp 1046 12 8 8 CD cord-015306-us58wwmp 1046 13 weeks week NNS cord-015306-us58wwmp 1046 14 , , , cord-015306-us58wwmp 1046 15 gradually gradually RB cord-015306-us58wwmp 1046 16 diminished diminish VBD cord-015306-us58wwmp 1046 17 within within IN cord-015306-us58wwmp 1046 18 15 15 CD cord-015306-us58wwmp 1046 19 months month NNS cord-015306-us58wwmp 1046 20 . . . cord-015306-us58wwmp 1047 1 It -PRON- PRP cord-015306-us58wwmp 1047 2 recognize recognize VBP cord-015306-us58wwmp 1047 3 clinical clinical JJ cord-015306-us58wwmp 1047 4 remission remission NN cord-015306-us58wwmp 1047 5 at at IN cord-015306-us58wwmp 1047 6 normal normal JJ cord-015306-us58wwmp 1047 7 renal renal JJ cord-015306-us58wwmp 1047 8 function function NN cord-015306-us58wwmp 1047 9 and and CC cord-015306-us58wwmp 1047 10 absence absence NN cord-015306-us58wwmp 1047 11 of of IN cord-015306-us58wwmp 1047 12 proteinuria proteinuria NN cord-015306-us58wwmp 1047 13 at at IN cord-015306-us58wwmp 1047 14 the the DT cord-015306-us58wwmp 1047 15 end end NN cord-015306-us58wwmp 1047 16 of of IN cord-015306-us58wwmp 1047 17 treatment treatment NN cord-015306-us58wwmp 1047 18 . . . cord-015306-us58wwmp 1048 1 In in IN cord-015306-us58wwmp 1048 2 all all DT cord-015306-us58wwmp 1048 3 patients patient NNS cord-015306-us58wwmp 1048 4 we -PRON- PRP cord-015306-us58wwmp 1048 5 estimated estimate VBD cord-015306-us58wwmp 1048 6 : : : cord-015306-us58wwmp 1048 7 proteinuria proteinuria NN cord-015306-us58wwmp 1048 8 , , , cord-015306-us58wwmp 1048 9 GFRs gfr NNS cord-015306-us58wwmp 1048 10 ( ( -LRB- cord-015306-us58wwmp 1048 11 calculated calculate VBN cord-015306-us58wwmp 1048 12 using use VBG cord-015306-us58wwmp 1048 13 Schwartz Schwartz NNP cord-015306-us58wwmp 1048 14 's 's POS cord-015306-us58wwmp 1048 15 formula formula NN cord-015306-us58wwmp 1048 16 ) ) -RRB- cord-015306-us58wwmp 1048 17 at at IN cord-015306-us58wwmp 1048 18 the the DT cord-015306-us58wwmp 1048 19 onset onset NN cord-015306-us58wwmp 1048 20 of of IN cord-015306-us58wwmp 1048 21 study study NN cord-015306-us58wwmp 1048 22 and and CC cord-015306-us58wwmp 1048 23 after after IN cord-015306-us58wwmp 1048 24 15 15 CD cord-015306-us58wwmp 1048 25 months month NNS cord-015306-us58wwmp 1048 26 . . . cord-015306-us58wwmp 1049 1 They -PRON- PRP cord-015306-us58wwmp 1049 2 had have VBD cord-015306-us58wwmp 1049 3 performed perform VBN cord-015306-us58wwmp 1049 4 renal renal JJ cord-015306-us58wwmp 1049 5 biopsy biopsy NN cord-015306-us58wwmp 1049 6 on on IN cord-015306-us58wwmp 1049 7 average average JJ cord-015306-us58wwmp 1049 8 0.69 0.69 CD cord-015306-us58wwmp 1049 9 ± ± CD cord-015306-us58wwmp 1049 10 0.95 0.95 CD cord-015306-us58wwmp 1049 11 years year NNS cord-015306-us58wwmp 1049 12 after after IN cord-015306-us58wwmp 1049 13 the the DT cord-015306-us58wwmp 1049 14 onset onset NN cord-015306-us58wwmp 1049 15 of of IN cord-015306-us58wwmp 1049 16 illness illness NN cord-015306-us58wwmp 1049 17 and and CC cord-015306-us58wwmp 1049 18 at at IN cord-015306-us58wwmp 1049 19 the the DT cord-015306-us58wwmp 1049 20 end end NN cord-015306-us58wwmp 1049 21 of of IN cord-015306-us58wwmp 1049 22 treatment treatment NN cord-015306-us58wwmp 1049 23 . . . cord-015306-us58wwmp 1050 1 We -PRON- PRP cord-015306-us58wwmp 1050 2 were be VBD cord-015306-us58wwmp 1050 3 analyzed analyze VBN cord-015306-us58wwmp 1050 4 the the DT cord-015306-us58wwmp 1050 5 histopathologic histopathologic JJ cord-015306-us58wwmp 1050 6 evaluation evaluation NN cord-015306-us58wwmp 1050 7 of of IN cord-015306-us58wwmp 1050 8 renal renal JJ cord-015306-us58wwmp 1050 9 biopsy biopsy NN cord-015306-us58wwmp 1050 10 specimens specimen NNS cord-015306-us58wwmp 1050 11 using use VBG cord-015306-us58wwmp 1050 12 the the DT cord-015306-us58wwmp 1050 13 WHO WHO NNP cord-015306-us58wwmp 1050 14 - - HYPH cord-015306-us58wwmp 1050 15 C C NNP cord-015306-us58wwmp 1050 16 ( ( -LRB- cord-015306-us58wwmp 1050 17 grade grade NN cord-015306-us58wwmp 1050 18 I I NNP cord-015306-us58wwmp 1050 19 - - HYPH cord-015306-us58wwmp 1050 20 V V NNP cord-015306-us58wwmp 1050 21 ) ) -RRB- cord-015306-us58wwmp 1050 22 and and CC cord-015306-us58wwmp 1050 23 Oxford Oxford NNP cord-015306-us58wwmp 1050 24 classification classification NN cord-015306-us58wwmp 1050 25 : : : cord-015306-us58wwmp 1051 1 ( ( -LRB- cord-015306-us58wwmp 1051 2 Mmesangial Mmesangial NNP cord-015306-us58wwmp 1051 3 hypercellularity hypercellularity NN cord-015306-us58wwmp 1051 4 , , , cord-015306-us58wwmp 1051 5 E e NN cord-015306-us58wwmp 1051 6 - - NN cord-015306-us58wwmp 1051 7 endocapillary endocapillary JJ cord-015306-us58wwmp 1051 8 hypercellularity hypercellularity NN cord-015306-us58wwmp 1051 9 , , , cord-015306-us58wwmp 1051 10 Ssegmental Ssegmental NNP cord-015306-us58wwmp 1051 11 sclerosis sclerosis NN cord-015306-us58wwmp 1051 12 , , , cord-015306-us58wwmp 1051 13 T T NNP cord-015306-us58wwmp 1051 14 - - HYPH cord-015306-us58wwmp 1051 15 tubular tubular JJ cord-015306-us58wwmp 1051 16 atrophy atrophy NN cord-015306-us58wwmp 1051 17 / / SYM cord-015306-us58wwmp 1051 18 interstitial interstitial JJ cord-015306-us58wwmp 1051 19 fibrosis fibrosis NN cord-015306-us58wwmp 1051 20 ; ; , cord-015306-us58wwmp 1051 21 absent absent JJ cord-015306-us58wwmp 1051 22 = = SYM cord-015306-us58wwmp 1051 23 0 0 CD cord-015306-us58wwmp 1051 24 , , , cord-015306-us58wwmp 1051 25 present=1 present=1 LS cord-015306-us58wwmp 1051 26 ) ) -RRB- cord-015306-us58wwmp 1051 27 . . . cord-015306-us58wwmp 1052 1 Results result NNS cord-015306-us58wwmp 1052 2 : : : cord-015306-us58wwmp 1053 1 In in IN cord-015306-us58wwmp 1053 2 patients patient NNS cord-015306-us58wwmp 1053 3 with with IN cord-015306-us58wwmp 1053 4 IgAN IgAN NNP cord-015306-us58wwmp 1053 5 we -PRON- PRP cord-015306-us58wwmp 1053 6 observed observe VBD cord-015306-us58wwmp 1053 7 : : : cord-015306-us58wwmp 1053 8 NS-1 NS-1 NNP cord-015306-us58wwmp 1053 9 , , , cord-015306-us58wwmp 1053 10 NPS-8 NPS-8 NNP cord-015306-us58wwmp 1053 11 ; ; : cord-015306-us58wwmp 1053 12 with with IN cord-015306-us58wwmp 1053 13 HSN HSN NNP cord-015306-us58wwmp 1053 14 : : : cord-015306-us58wwmp 1053 15 NS-7 NS-7 NNP cord-015306-us58wwmp 1053 16 , , , cord-015306-us58wwmp 1053 17 NPS-2 NPS-2 NNP cord-015306-us58wwmp 1053 18 . . . cord-015306-us58wwmp 1054 1 After after IN cord-015306-us58wwmp 1054 2 the the DT cord-015306-us58wwmp 1054 3 treatment treatment NN cord-015306-us58wwmp 1054 4 AZA AZA NNP cord-015306-us58wwmp 1054 5 / / , cord-015306-us58wwmp 1054 6 Pred Pred NNP cord-015306-us58wwmp 1054 7 we -PRON- PRP cord-015306-us58wwmp 1054 8 noted note VBD cord-015306-us58wwmp 1054 9 clinical clinical JJ cord-015306-us58wwmp 1054 10 remission remission NN cord-015306-us58wwmp 1054 11 in in IN cord-015306-us58wwmp 1054 12 all all DT cord-015306-us58wwmp 1054 13 children child NNS cord-015306-us58wwmp 1054 14 with with IN cord-015306-us58wwmp 1054 15 IgAN IgAN NNP cord-015306-us58wwmp 1054 16 and and CC cord-015306-us58wwmp 1054 17 89 89 CD cord-015306-us58wwmp 1054 18 % % NN cord-015306-us58wwmp 1054 19 with with IN cord-015306-us58wwmp 1054 20 HSN HSN NNP cord-015306-us58wwmp 1054 21 . . . cord-015306-us58wwmp 1055 1 GFR GFR NNP cord-015306-us58wwmp 1055 2 was be VBD cord-015306-us58wwmp 1055 3 normal normal JJ cord-015306-us58wwmp 1055 4 before before IN cord-015306-us58wwmp 1055 5 and and CC cord-015306-us58wwmp 1055 6 after after IN cord-015306-us58wwmp 1055 7 treatment treatment NN cord-015306-us58wwmp 1055 8 . . . cord-015306-us58wwmp 1056 1 At at IN cord-015306-us58wwmp 1056 2 the the DT cord-015306-us58wwmp 1056 3 onset onset NN cord-015306-us58wwmp 1056 4 of of IN cord-015306-us58wwmp 1056 5 illness illness NN cord-015306-us58wwmp 1056 6 IgAN IgAN NNP cord-015306-us58wwmp 1056 7 patients patient NNS cord-015306-us58wwmp 1056 8 had have VBD cord-015306-us58wwmp 1056 9 : : : cord-015306-us58wwmp 1056 10 grade grade NN cord-015306-us58wwmp 1056 11 III-6 III-6 NNP cord-015306-us58wwmp 1056 12 , , , cord-015306-us58wwmp 1056 13 grade grade NN cord-015306-us58wwmp 1056 14 IV-3 IV-3 NNP cord-015306-us58wwmp 1056 15 according accord VBG cord-015306-us58wwmp 1056 16 to to IN cord-015306-us58wwmp 1056 17 WHO WHO NNP cord-015306-us58wwmp 1056 18 - - HYPH cord-015306-us58wwmp 1056 19 C C NNP cord-015306-us58wwmp 1056 20 ; ; . cord-015306-us58wwmp 1057 1 HSN HSN NNP cord-015306-us58wwmp 1057 2 had have VBD cord-015306-us58wwmp 1057 3 : : : cord-015306-us58wwmp 1057 4 grade grade NN cord-015306-us58wwmp 1057 5 II II NNP cord-015306-us58wwmp 1057 6 -2 -2 NNP cord-015306-us58wwmp 1057 7 , , , cord-015306-us58wwmp 1057 8 grade grade NN cord-015306-us58wwmp 1057 9 III-6 III-6 NNP cord-015306-us58wwmp 1057 10 , , , cord-015306-us58wwmp 1057 11 grade grade NN cord-015306-us58wwmp 1057 12 IV IV NNP cord-015306-us58wwmp 1057 13 -1 -1 NNP cord-015306-us58wwmp 1057 14 ; ; : cord-015306-us58wwmp 1057 15 at at IN cord-015306-us58wwmp 1057 16 the the DT cord-015306-us58wwmp 1057 17 end end NN cord-015306-us58wwmp 1057 18 of of IN cord-015306-us58wwmp 1057 19 therapy therapy NN cord-015306-us58wwmp 1057 20 we -PRON- PRP cord-015306-us58wwmp 1057 21 observed observe VBD cord-015306-us58wwmp 1057 22 positive positive JJ cord-015306-us58wwmp 1057 23 effect effect NN cord-015306-us58wwmp 1057 24 in in IN cord-015306-us58wwmp 1057 25 WHO WHO NNP cord-015306-us58wwmp 1057 26 - - HYPH cord-015306-us58wwmp 1057 27 C C NNP cord-015306-us58wwmp 1057 28 only only RB cord-015306-us58wwmp 1057 29 in in IN cord-015306-us58wwmp 1057 30 2 2 CD cord-015306-us58wwmp 1057 31 ( ( -LRB- cord-015306-us58wwmp 1057 32 22 22 CD cord-015306-us58wwmp 1057 33 % % NN cord-015306-us58wwmp 1057 34 ) ) -RRB- cord-015306-us58wwmp 1058 1 IgAN IgAN NNP cord-015306-us58wwmp 1058 2 patients patient NNS cord-015306-us58wwmp 1058 3 and and CC cord-015306-us58wwmp 1058 4 in in IN cord-015306-us58wwmp 1058 5 5 5 CD cord-015306-us58wwmp 1058 6 ( ( -LRB- cord-015306-us58wwmp 1058 7 56 56 CD cord-015306-us58wwmp 1058 8 % % NN cord-015306-us58wwmp 1058 9 ) ) -RRB- cord-015306-us58wwmp 1058 10 HSN HSN NNP cord-015306-us58wwmp 1058 11 , , , cord-015306-us58wwmp 1058 12 without without IN cord-015306-us58wwmp 1058 13 progression progression NN cord-015306-us58wwmp 1058 14 properly properly RB cord-015306-us58wwmp 1058 15 6 6 CD cord-015306-us58wwmp 1058 16 ( ( -LRB- cord-015306-us58wwmp 1058 17 67 67 CD cord-015306-us58wwmp 1058 18 % % NN cord-015306-us58wwmp 1058 19 ) ) -RRB- cord-015306-us58wwmp 1058 20 and and CC cord-015306-us58wwmp 1058 21 4 4 CD cord-015306-us58wwmp 1058 22 ( ( -LRB- cord-015306-us58wwmp 1058 23 44 44 CD cord-015306-us58wwmp 1058 24 % % NN cord-015306-us58wwmp 1058 25 ) ) -RRB- cord-015306-us58wwmp 1058 26 . . . cord-015306-us58wwmp 1059 1 In in IN cord-015306-us58wwmp 1059 2 O o NN cord-015306-us58wwmp 1059 3 - - HYPH cord-015306-us58wwmp 1059 4 C C NNP cord-015306-us58wwmp 1059 5 of of IN cord-015306-us58wwmp 1059 6 IgAN IgAN NNP cord-015306-us58wwmp 1059 7 patients patient NNS cord-015306-us58wwmp 1059 8 we -PRON- PRP cord-015306-us58wwmp 1059 9 observed observe VBD cord-015306-us58wwmp 1059 10 nobody nobody NN cord-015306-us58wwmp 1059 11 with with IN cord-015306-us58wwmp 1059 12 total total JJ cord-015306-us58wwmp 1059 13 regression regression NN cord-015306-us58wwmp 1059 14 of of IN cord-015306-us58wwmp 1059 15 changes change NNS cord-015306-us58wwmp 1059 16 , , , cord-015306-us58wwmp 1059 17 only only RB cord-015306-us58wwmp 1059 18 3 3 CD cord-015306-us58wwmp 1059 19 children child NNS cord-015306-us58wwmp 1059 20 had have VBD cord-015306-us58wwmp 1059 21 M0 m0 NN cord-015306-us58wwmp 1059 22 or or CC cord-015306-us58wwmp 1059 23 E0 E0 NNP cord-015306-us58wwmp 1059 24 or or CC cord-015306-us58wwmp 1059 25 S0 s0 NN cord-015306-us58wwmp 1059 26 after after IN cord-015306-us58wwmp 1059 27 treatment treatment NN cord-015306-us58wwmp 1059 28 . . . cord-015306-us58wwmp 1060 1 In in IN cord-015306-us58wwmp 1060 2 patients patient NNS cord-015306-us58wwmp 1060 3 with with IN cord-015306-us58wwmp 1060 4 HSN HSN NNP cord-015306-us58wwmp 1060 5 we -PRON- PRP cord-015306-us58wwmp 1060 6 noted note VBD cord-015306-us58wwmp 1060 7 total total JJ cord-015306-us58wwmp 1060 8 regression regression NN cord-015306-us58wwmp 1060 9 of of IN cord-015306-us58wwmp 1060 10 changes change NNS cord-015306-us58wwmp 1060 11 in in IN cord-015306-us58wwmp 1060 12 4 4 CD cord-015306-us58wwmp 1060 13 ( ( -LRB- cord-015306-us58wwmp 1060 14 44 44 CD cord-015306-us58wwmp 1060 15 % % NN cord-015306-us58wwmp 1060 16 ) ) -RRB- cord-015306-us58wwmp 1060 17 , , , cord-015306-us58wwmp 1060 18 in in IN cord-015306-us58wwmp 1060 19 other other JJ cord-015306-us58wwmp 1060 20 3-M0 3-m0 NN cord-015306-us58wwmp 1060 21 or or CC cord-015306-us58wwmp 1060 22 E0 e0 NN cord-015306-us58wwmp 1060 23 or or CC cord-015306-us58wwmp 1060 24 T0 T0 NNP cord-015306-us58wwmp 1060 25 . . . cord-015306-us58wwmp 1061 1 Conclusion conclusion NN cord-015306-us58wwmp 1061 2 : : : cord-015306-us58wwmp 1062 1 AZA AZA NNP cord-015306-us58wwmp 1062 2 / / SYM cord-015306-us58wwmp 1062 3 Pred Pred NNP cord-015306-us58wwmp 1062 4 therapy therapy NN cord-015306-us58wwmp 1062 5 used use VBN cord-015306-us58wwmp 1062 6 in in IN cord-015306-us58wwmp 1062 7 children child NNS cord-015306-us58wwmp 1062 8 with with IN cord-015306-us58wwmp 1062 9 IgAN IgAN NNP cord-015306-us58wwmp 1062 10 and and CC cord-015306-us58wwmp 1062 11 HSN HSN NNP cord-015306-us58wwmp 1062 12 can can MD cord-015306-us58wwmp 1062 13 make make VB cord-015306-us58wwmp 1062 14 clinical clinical JJ cord-015306-us58wwmp 1062 15 remission remission NN cord-015306-us58wwmp 1062 16 in in IN cord-015306-us58wwmp 1062 17 both both DT cord-015306-us58wwmp 1062 18 groups group NNS cord-015306-us58wwmp 1062 19 , , , cord-015306-us58wwmp 1062 20 but but CC cord-015306-us58wwmp 1063 1 histopathological histopathological NNP cord-015306-us58wwmp 1063 2 regression regression NN cord-015306-us58wwmp 1063 3 - - , cord-015306-us58wwmp 1063 4 more more RBR cord-015306-us58wwmp 1063 5 frequent frequent JJ cord-015306-us58wwmp 1063 6 in in IN cord-015306-us58wwmp 1063 7 HSN HSN NNP cord-015306-us58wwmp 1063 8 . . . cord-015306-us58wwmp 1064 1 Oxford Oxford NNP cord-015306-us58wwmp 1064 2 and and CC cord-015306-us58wwmp 1064 3 WHO WHO NNP cord-015306-us58wwmp 1064 4 classifications classification NNS cord-015306-us58wwmp 1064 5 are be VBP cord-015306-us58wwmp 1064 6 very very RB cord-015306-us58wwmp 1064 7 useful useful JJ cord-015306-us58wwmp 1064 8 for for IN cord-015306-us58wwmp 1064 9 estimation estimation NN cord-015306-us58wwmp 1064 10 of of IN cord-015306-us58wwmp 1064 11 efficiency efficiency NN cord-015306-us58wwmp 1064 12 of of IN cord-015306-us58wwmp 1064 13 treatment treatment NN cord-015306-us58wwmp 1064 14 . . . cord-015306-us58wwmp 1065 1 10-year 10-year CD cord-015306-us58wwmp 1065 2 follow follow NN cord-015306-us58wwmp 1065 3 - - HYPH cord-015306-us58wwmp 1065 4 up up NN cord-015306-us58wwmp 1065 5 of of IN cord-015306-us58wwmp 1065 6 pediatric pediatric JJ cord-015306-us58wwmp 1065 7 Hennoch Hennoch NNP cord-015306-us58wwmp 1065 8 Schönlein Schönlein NNP cord-015306-us58wwmp 1065 9 purpura purpura NN cord-015306-us58wwmp 1065 10 with with IN cord-015306-us58wwmp 1065 11 renal renal JJ cord-015306-us58wwmp 1065 12 involvement involvement NN cord-015306-us58wwmp 1065 13 Elena Elena NNP cord-015306-us58wwmp 1065 14 Tudorache Tudorache NNP cord-015306-us58wwmp 1065 15 1 1 CD cord-015306-us58wwmp 1065 16 , , , cord-015306-us58wwmp 1065 17 Christine Christine NNP cord-015306-us58wwmp 1065 18 Azema Azema NNP cord-015306-us58wwmp 1065 19 1 1 CD cord-015306-us58wwmp 1065 20 , , , cord-015306-us58wwmp 1065 21 Stéphane Stéphane NNP cord-015306-us58wwmp 1065 22 Decramer Decramer NNP cord-015306-us58wwmp 1065 23 2 2 CD cord-015306-us58wwmp 1065 24 , , , cord-015306-us58wwmp 1065 25 Georges Georges NNP cord-015306-us58wwmp 1065 26 Deschênes Deschênes NNP cord-015306-us58wwmp 1065 27 3 3 CD cord-015306-us58wwmp 1065 28 , , , cord-015306-us58wwmp 1065 29 Tim Tim NNP cord-015306-us58wwmp 1065 30 Ulinski Ulinski NNP cord-015306-us58wwmp 1065 31 1 1 CD cord-015306-us58wwmp 1065 32 1 1 CD cord-015306-us58wwmp 1065 33 Pediatric Pediatric NNP cord-015306-us58wwmp 1065 34 Nephrology Nephrology NNP cord-015306-us58wwmp 1065 35 , , , cord-015306-us58wwmp 1065 36 Armand Armand NNP cord-015306-us58wwmp 1065 37 Trousseau Trousseau NNP cord-015306-us58wwmp 1065 38 Hospital Hospital NNP cord-015306-us58wwmp 1065 39 , , , cord-015306-us58wwmp 1065 40 Paris Paris NNP cord-015306-us58wwmp 1065 41 , , , cord-015306-us58wwmp 1065 42 France France NNP cord-015306-us58wwmp 1065 43 2 2 CD cord-015306-us58wwmp 1065 44 Pediatric Pediatric NNP cord-015306-us58wwmp 1065 45 Nephrology Nephrology NNP cord-015306-us58wwmp 1065 46 , , , cord-015306-us58wwmp 1065 47 CHU CHU NNP cord-015306-us58wwmp 1065 48 Toulouse Toulouse NNP cord-015306-us58wwmp 1065 49 , , , cord-015306-us58wwmp 1065 50 Toulouse Toulouse NNP cord-015306-us58wwmp 1065 51 , , , cord-015306-us58wwmp 1065 52 France France NNP cord-015306-us58wwmp 1065 53 3 3 CD cord-015306-us58wwmp 1065 54 Pediatric Pediatric NNP cord-015306-us58wwmp 1065 55 Nephrology Nephrology NNP cord-015306-us58wwmp 1065 56 , , , cord-015306-us58wwmp 1065 57 Robert Robert NNP cord-015306-us58wwmp 1065 58 Debré Debré NNP cord-015306-us58wwmp 1065 59 Hospital Hospital NNP cord-015306-us58wwmp 1065 60 , , , cord-015306-us58wwmp 1065 61 Paris Paris NNP cord-015306-us58wwmp 1065 62 , , , cord-015306-us58wwmp 1066 1 France France NNP cord-015306-us58wwmp 1066 2 Objective Objective NNP cord-015306-us58wwmp 1066 3 : : : cord-015306-us58wwmp 1067 1 The the DT cord-015306-us58wwmp 1067 2 aim aim NN cord-015306-us58wwmp 1067 3 of of IN cord-015306-us58wwmp 1067 4 this this DT cord-015306-us58wwmp 1067 5 study study NN cord-015306-us58wwmp 1067 6 was be VBD cord-015306-us58wwmp 1067 7 to to TO cord-015306-us58wwmp 1067 8 determine determine VB cord-015306-us58wwmp 1067 9 the the DT cord-015306-us58wwmp 1067 10 long long JJ cord-015306-us58wwmp 1067 11 - - HYPH cord-015306-us58wwmp 1067 12 term term NN cord-015306-us58wwmp 1067 13 outcome outcome NN cord-015306-us58wwmp 1067 14 in in IN cord-015306-us58wwmp 1067 15 children child NNS cord-015306-us58wwmp 1067 16 with with IN cord-015306-us58wwmp 1067 17 HSP HSP NNP cord-015306-us58wwmp 1067 18 nephritis nephritis NN cord-015306-us58wwmp 1067 19 who who WP cord-015306-us58wwmp 1067 20 underwent undergo VBD cord-015306-us58wwmp 1067 21 a a DT cord-015306-us58wwmp 1067 22 renal renal JJ cord-015306-us58wwmp 1067 23 biopsy biopsy NN cord-015306-us58wwmp 1067 24 and and CC cord-015306-us58wwmp 1067 25 to to TO cord-015306-us58wwmp 1067 26 identify identify VB cord-015306-us58wwmp 1067 27 possible possible JJ cord-015306-us58wwmp 1067 28 correlation correlation NN cord-015306-us58wwmp 1067 29 between between IN cord-015306-us58wwmp 1067 30 disease disease NN cord-015306-us58wwmp 1067 31 parameters parameter NNS cord-015306-us58wwmp 1067 32 and and CC cord-015306-us58wwmp 1067 33 treatment treatment NN cord-015306-us58wwmp 1067 34 . . . cord-015306-us58wwmp 1068 1 We -PRON- PRP cord-015306-us58wwmp 1068 2 included include VBD cord-015306-us58wwmp 1068 3 retrospectively retrospectively RB cord-015306-us58wwmp 1068 4 all all DT cord-015306-us58wwmp 1068 5 patients patient NNS cord-015306-us58wwmp 1068 6 with with IN cord-015306-us58wwmp 1068 7 renal renal JJ cord-015306-us58wwmp 1068 8 biopsy biopsy NNP cord-015306-us58wwmp 1068 9 proven prove VBN cord-015306-us58wwmp 1068 10 IgA IgA NNP cord-015306-us58wwmp 1068 11 nephropathy nephropathy NN cord-015306-us58wwmp 1068 12 related relate VBN cord-015306-us58wwmp 1068 13 to to IN cord-015306-us58wwmp 1068 14 HSP HSP NNP cord-015306-us58wwmp 1068 15 of of IN cord-015306-us58wwmp 1068 16 three three CD cord-015306-us58wwmp 1068 17 pediatric pediatric JJ cord-015306-us58wwmp 1068 18 nephrology nephrology NN cord-015306-us58wwmp 1068 19 centres centre NNS cord-015306-us58wwmp 1068 20 over over IN cord-015306-us58wwmp 1068 21 a a DT cord-015306-us58wwmp 1068 22 10-year 10-year CD cord-015306-us58wwmp 1068 23 period period NN cord-015306-us58wwmp 1068 24 . . . cord-015306-us58wwmp 1069 1 Results result NNS cord-015306-us58wwmp 1069 2 : : : cord-015306-us58wwmp 1069 3 142 142 CD cord-015306-us58wwmp 1069 4 patients patient NNS cord-015306-us58wwmp 1069 5 were be VBD cord-015306-us58wwmp 1069 6 included include VBN cord-015306-us58wwmp 1069 7 . . . cord-015306-us58wwmp 1070 1 Nephrotic nephrotic JJ cord-015306-us58wwmp 1070 2 range range NN cord-015306-us58wwmp 1070 3 proteinuria proteinuria NN cord-015306-us58wwmp 1070 4 was be VBD cord-015306-us58wwmp 1070 5 present present JJ cord-015306-us58wwmp 1070 6 in in IN cord-015306-us58wwmp 1070 7 28 28 CD cord-015306-us58wwmp 1070 8 % % NN cord-015306-us58wwmp 1070 9 with with IN cord-015306-us58wwmp 1070 10 grade grade NN cord-015306-us58wwmp 1070 11 II II NNP cord-015306-us58wwmp 1070 12 , , , cord-015306-us58wwmp 1070 13 60 60 CD cord-015306-us58wwmp 1070 14 % % NN cord-015306-us58wwmp 1070 15 with with IN cord-015306-us58wwmp 1070 16 grade grade NN cord-015306-us58wwmp 1070 17 III III NNP cord-015306-us58wwmp 1070 18 and and CC cord-015306-us58wwmp 1070 19 90 90 CD cord-015306-us58wwmp 1070 20 % % NN cord-015306-us58wwmp 1070 21 with with IN cord-015306-us58wwmp 1070 22 grade grade NN cord-015306-us58wwmp 1070 23 IV IV NNP cord-015306-us58wwmp 1070 24 lesions lesion NNS cord-015306-us58wwmp 1070 25 . . . cord-015306-us58wwmp 1071 1 Renal renal JJ cord-015306-us58wwmp 1071 2 function function NN cord-015306-us58wwmp 1071 3 was be VBD cord-015306-us58wwmp 1071 4 impaired impair VBN cord-015306-us58wwmp 1071 5 in in IN cord-015306-us58wwmp 1071 6 14 14 CD cord-015306-us58wwmp 1071 7 % % NN cord-015306-us58wwmp 1071 8 . . . cord-015306-us58wwmp 1072 1 Significant significant JJ cord-015306-us58wwmp 1072 2 proteinuria proteinuria NN cord-015306-us58wwmp 1073 1 > > XX cord-015306-us58wwmp 1074 1 500 500 CD cord-015306-us58wwmp 1074 2 mg mg NNP cord-015306-us58wwmp 1074 3 / / SYM cord-015306-us58wwmp 1074 4 L L NNP cord-015306-us58wwmp 1074 5 was be VBD cord-015306-us58wwmp 1074 6 found find VBN cord-015306-us58wwmp 1074 7 in in IN cord-015306-us58wwmp 1074 8 9/48 9/48 CD cord-015306-us58wwmp 1074 9 patients patient NNS cord-015306-us58wwmp 1075 1 3 3 CD cord-015306-us58wwmp 1075 2 years year NNS cord-015306-us58wwmp 1075 3 post post VBP cord-015306-us58wwmp 1075 4 renal renal JJ cord-015306-us58wwmp 1075 5 biopsy biopsy NN cord-015306-us58wwmp 1075 6 , , , cord-015306-us58wwmp 1075 7 in in IN cord-015306-us58wwmp 1075 8 8/25 8/25 CD cord-015306-us58wwmp 1075 9 patients patient NNS cord-015306-us58wwmp 1075 10 at at IN cord-015306-us58wwmp 1075 11 5 5 CD cord-015306-us58wwmp 1075 12 years year NNS cord-015306-us58wwmp 1075 13 and and CC cord-015306-us58wwmp 1075 14 in in IN cord-015306-us58wwmp 1075 15 3/14 3/14 CD cord-015306-us58wwmp 1075 16 patients patient NNS cord-015306-us58wwmp 1075 17 at at IN cord-015306-us58wwmp 1075 18 10 10 CD cord-015306-us58wwmp 1075 19 years year NNS cord-015306-us58wwmp 1075 20 . . . cord-015306-us58wwmp 1076 1 There there EX cord-015306-us58wwmp 1076 2 was be VBD cord-015306-us58wwmp 1076 3 no no DT cord-015306-us58wwmp 1076 4 correlation correlation NN cord-015306-us58wwmp 1076 5 between between IN cord-015306-us58wwmp 1076 6 risk risk NN cord-015306-us58wwmp 1076 7 for for IN cord-015306-us58wwmp 1076 8 proteinuria proteinuria NN cord-015306-us58wwmp 1076 9 at at IN cord-015306-us58wwmp 1076 10 3 3 CD cord-015306-us58wwmp 1076 11 , , , cord-015306-us58wwmp 1076 12 5 5 CD cord-015306-us58wwmp 1076 13 , , , cord-015306-us58wwmp 1076 14 or or CC cord-015306-us58wwmp 1076 15 10 10 CD cord-015306-us58wwmp 1076 16 years year NNS cord-015306-us58wwmp 1076 17 with with IN cord-015306-us58wwmp 1076 18 initial initial JJ cord-015306-us58wwmp 1076 19 histological histological JJ cord-015306-us58wwmp 1076 20 lesions lesion NNS cord-015306-us58wwmp 1076 21 . . . cord-015306-us58wwmp 1077 1 There there EX cord-015306-us58wwmp 1077 2 was be VBD cord-015306-us58wwmp 1077 3 a a DT cord-015306-us58wwmp 1077 4 tendency tendency NN cord-015306-us58wwmp 1077 5 to to IN cord-015306-us58wwmp 1077 6 higher high JJR cord-015306-us58wwmp 1077 7 residual residual JJ cord-015306-us58wwmp 1077 8 proteinuria proteinuria NN cord-015306-us58wwmp 1077 9 in in IN cord-015306-us58wwmp 1077 10 patients patient NNS cord-015306-us58wwmp 1077 11 with with IN cord-015306-us58wwmp 1077 12 nephrotic nephrotic JJ cord-015306-us58wwmp 1077 13 proteinuria proteinuria NN cord-015306-us58wwmp 1077 14 at at IN cord-015306-us58wwmp 1077 15 disease disease NN cord-015306-us58wwmp 1077 16 onset onset NN cord-015306-us58wwmp 1077 17 and and CC cord-015306-us58wwmp 1077 18 also also RB cord-015306-us58wwmp 1077 19 for for IN cord-015306-us58wwmp 1077 20 patients patient NNS cord-015306-us58wwmp 1077 21 who who WP cord-015306-us58wwmp 1077 22 were be VBD cord-015306-us58wwmp 1077 23 not not RB cord-015306-us58wwmp 1077 24 treated treat VBN cord-015306-us58wwmp 1077 25 with with IN cord-015306-us58wwmp 1077 26 steroid steroid NN cord-015306-us58wwmp 1077 27 pulses pulse NNS cord-015306-us58wwmp 1077 28 at at IN cord-015306-us58wwmp 1077 29 disease disease NN cord-015306-us58wwmp 1077 30 onset onset NN cord-015306-us58wwmp 1077 31 with with IN cord-015306-us58wwmp 1077 32 310 310 CD cord-015306-us58wwmp 1077 33 vs. vs. NN cord-015306-us58wwmp 1077 34 175 175 CD cord-015306-us58wwmp 1077 35 mg mg NNP cord-015306-us58wwmp 1077 36 / / SYM cord-015306-us58wwmp 1077 37 L L NNP cord-015306-us58wwmp 1077 38 ( ( -LRB- cord-015306-us58wwmp 1077 39 p=0.06 p=0.06 NNP cord-015306-us58wwmp 1077 40 ) ) -RRB- cord-015306-us58wwmp 1077 41 at at IN cord-015306-us58wwmp 1077 42 three three CD cord-015306-us58wwmp 1077 43 months month NNS cord-015306-us58wwmp 1077 44 , , , cord-015306-us58wwmp 1077 45 100 100 CD cord-015306-us58wwmp 1077 46 vs. vs. NN cord-015306-us58wwmp 1077 47 50 50 CD cord-015306-us58wwmp 1077 48 mg mg NNP cord-015306-us58wwmp 1077 49 / / SYM cord-015306-us58wwmp 1077 50 L L NNP cord-015306-us58wwmp 1077 51 ( ( -LRB- cord-015306-us58wwmp 1077 52 p=0.93 p=0.93 NNP cord-015306-us58wwmp 1077 53 ) ) -RRB- cord-015306-us58wwmp 1077 54 at at IN cord-015306-us58wwmp 1077 55 one one CD cord-015306-us58wwmp 1077 56 year year NN cord-015306-us58wwmp 1077 57 , , , cord-015306-us58wwmp 1077 58 720 720 CD cord-015306-us58wwmp 1077 59 vs. vs. FW cord-015306-us58wwmp 1077 60 150 150 CD cord-015306-us58wwmp 1077 61 mg mg NNP cord-015306-us58wwmp 1077 62 / / SYM cord-015306-us58wwmp 1077 63 L L NNP cord-015306-us58wwmp 1077 64 ( ( -LRB- cord-015306-us58wwmp 1077 65 p=0.1 p=0.1 NNP cord-015306-us58wwmp 1077 66 ) ) -RRB- cord-015306-us58wwmp 1077 67 at at IN cord-015306-us58wwmp 1077 68 five five CD cord-015306-us58wwmp 1077 69 years year NNS cord-015306-us58wwmp 1077 70 , , , cord-015306-us58wwmp 1077 71 and and CC cord-015306-us58wwmp 1077 72 520 520 CD cord-015306-us58wwmp 1077 73 vs. vs. NN cord-015306-us58wwmp 1077 74 355 355 CD cord-015306-us58wwmp 1077 75 mg mg NNP cord-015306-us58wwmp 1077 76 / / SYM cord-015306-us58wwmp 1077 77 L L NNP cord-015306-us58wwmp 1077 78 ( ( -LRB- cord-015306-us58wwmp 1077 79 p=0.35 p=0.35 NNP cord-015306-us58wwmp 1077 80 ) ) -RRB- cord-015306-us58wwmp 1077 81 at at IN cord-015306-us58wwmp 1077 82 ten ten CD cord-015306-us58wwmp 1077 83 years year NNS cord-015306-us58wwmp 1077 84 . . . cord-015306-us58wwmp 1078 1 There there EX cord-015306-us58wwmp 1078 2 was be VBD cord-015306-us58wwmp 1078 3 a a DT cord-015306-us58wwmp 1078 4 tendency tendency NN cord-015306-us58wwmp 1078 5 to to TO cord-015306-us58wwmp 1078 6 less less RBR cord-015306-us58wwmp 1078 7 proteinuria proteinuria NN cord-015306-us58wwmp 1078 8 in in IN cord-015306-us58wwmp 1078 9 the the DT cord-015306-us58wwmp 1078 10 long long JJ cord-015306-us58wwmp 1078 11 term term NN cord-015306-us58wwmp 1078 12 for for IN cord-015306-us58wwmp 1078 13 those those DT cord-015306-us58wwmp 1078 14 with with IN cord-015306-us58wwmp 1078 15 early early JJ cord-015306-us58wwmp 1078 16 steroid steroid NN cord-015306-us58wwmp 1078 17 pulses pulse NNS cord-015306-us58wwmp 1078 18 ( ( -LRB- cord-015306-us58wwmp 1078 19 < < NNP cord-015306-us58wwmp 1078 20 15 15 CD cord-015306-us58wwmp 1078 21 days day NNS cord-015306-us58wwmp 1078 22 vs. vs. FW cord-015306-us58wwmp 1078 23 > > XX cord-015306-us58wwmp 1078 24 16 16 CD cord-015306-us58wwmp 1078 25 days day NNS cord-015306-us58wwmp 1078 26 after after IN cord-015306-us58wwmp 1078 27 proteinuria proteinuria NN cord-015306-us58wwmp 1078 28 onset onset NN cord-015306-us58wwmp 1078 29 ( ( -LRB- cord-015306-us58wwmp 1078 30 p=0.16).In p=0.16).in VB cord-015306-us58wwmp 1078 31 patients patient NNS cord-015306-us58wwmp 1078 32 with with IN cord-015306-us58wwmp 1078 33 ACEi ACEi NNS cord-015306-us58wwmp 1078 34 / / SYM cord-015306-us58wwmp 1078 35 ARB arb NN cord-015306-us58wwmp 1078 36 treatment treatment NN cord-015306-us58wwmp 1078 37 within within IN cord-015306-us58wwmp 1078 38 15 15 CD cord-015306-us58wwmp 1078 39 days day NNS cord-015306-us58wwmp 1078 40 after after IN cord-015306-us58wwmp 1078 41 renal renal JJ cord-015306-us58wwmp 1078 42 disease disease NN cord-015306-us58wwmp 1078 43 onset onset NN cord-015306-us58wwmp 1078 44 , , , cord-015306-us58wwmp 1078 45 compared compare VBN cord-015306-us58wwmp 1078 46 to to IN cord-015306-us58wwmp 1078 47 those those DT cord-015306-us58wwmp 1078 48 who who WP cord-015306-us58wwmp 1078 49 were be VBD cord-015306-us58wwmp 1078 50 treated treat VBN cord-015306-us58wwmp 1078 51 later later RB cord-015306-us58wwmp 1078 52 ( ( -LRB- cord-015306-us58wwmp 1078 53 > > NFP cord-015306-us58wwmp 1078 54 one one CD cord-015306-us58wwmp 1078 55 month month NN cord-015306-us58wwmp 1078 56 ) ) -RRB- cord-015306-us58wwmp 1078 57 , , , cord-015306-us58wwmp 1078 58 proteinuria proteinuria NN cord-015306-us58wwmp 1078 59 was be VBD cord-015306-us58wwmp 1078 60 significantly significantly RB cord-015306-us58wwmp 1078 61 lower low JJR cord-015306-us58wwmp 1078 62 at at IN cord-015306-us58wwmp 1078 63 6 6 CD cord-015306-us58wwmp 1078 64 ( ( -LRB- cord-015306-us58wwmp 1078 65 p=0.02 p=0.02 NN cord-015306-us58wwmp 1078 66 ) ) -RRB- cord-015306-us58wwmp 1078 67 and and CC cord-015306-us58wwmp 1078 68 12 12 CD cord-015306-us58wwmp 1078 69 months month NNS cord-015306-us58wwmp 1078 70 ( ( -LRB- cord-015306-us58wwmp 1078 71 p=0.03 p=0.03 NN cord-015306-us58wwmp 1078 72 ) ) -RRB- cord-015306-us58wwmp 1078 73 . . . cord-015306-us58wwmp 1079 1 Among among IN cord-015306-us58wwmp 1079 2 18 18 CD cord-015306-us58wwmp 1079 3 control control NN cord-015306-us58wwmp 1079 4 kidney kidney NN cord-015306-us58wwmp 1079 5 biopsies biopsy NNS cord-015306-us58wwmp 1079 6 , , , cord-015306-us58wwmp 1079 7 50 50 CD cord-015306-us58wwmp 1079 8 % % NN cord-015306-us58wwmp 1079 9 show show NN cord-015306-us58wwmp 1079 10 fibrosis fibrosis NN cord-015306-us58wwmp 1079 11 of of IN cord-015306-us58wwmp 1079 12 different different JJ cord-015306-us58wwmp 1079 13 degree degree NN cord-015306-us58wwmp 1079 14 unrelated unrelated JJ cord-015306-us58wwmp 1079 15 to to IN cord-015306-us58wwmp 1079 16 initial initial JJ cord-015306-us58wwmp 1079 17 histology histology NN cord-015306-us58wwmp 1079 18 . . . cord-015306-us58wwmp 1080 1 Conclusion conclusion NN cord-015306-us58wwmp 1080 2 : : : cord-015306-us58wwmp 1080 3 There there EX cord-015306-us58wwmp 1080 4 is be VBZ cord-015306-us58wwmp 1080 5 a a DT cord-015306-us58wwmp 1080 6 risk risk NN cord-015306-us58wwmp 1080 7 to to TO cord-015306-us58wwmp 1080 8 underestimate underestimate VB cord-015306-us58wwmp 1080 9 long long JJ cord-015306-us58wwmp 1080 10 term term NN cord-015306-us58wwmp 1080 11 disease disease NN cord-015306-us58wwmp 1080 12 severity severity NN cord-015306-us58wwmp 1080 13 in in IN cord-015306-us58wwmp 1080 14 patients patient NNS cord-015306-us58wwmp 1080 15 with with IN cord-015306-us58wwmp 1080 16 low low JJ cord-015306-us58wwmp 1080 17 ISKDC ISKDC NNP cord-015306-us58wwmp 1080 18 classes class NNS cord-015306-us58wwmp 1080 19 . . . cord-015306-us58wwmp 1081 1 There there EX cord-015306-us58wwmp 1081 2 is be VBZ cord-015306-us58wwmp 1081 3 need need NN cord-015306-us58wwmp 1081 4 for for IN cord-015306-us58wwmp 1081 5 prospective prospective JJ cord-015306-us58wwmp 1081 6 long long JJ cord-015306-us58wwmp 1081 7 term term NN cord-015306-us58wwmp 1081 8 studies study NNS cord-015306-us58wwmp 1081 9 to to TO cord-015306-us58wwmp 1081 10 explore explore VB cord-015306-us58wwmp 1081 11 the the DT cord-015306-us58wwmp 1081 12 benefit benefit NN cord-015306-us58wwmp 1081 13 of of IN cord-015306-us58wwmp 1081 14 early early JJ cord-015306-us58wwmp 1081 15 ACEi ACEi NNS cord-015306-us58wwmp 1081 16 / / SYM cord-015306-us58wwmp 1081 17 ARB ARB NNP cord-015306-us58wwmp 1081 18 and/or and/or CC cord-015306-us58wwmp 1081 19 steroid steroid NN cord-015306-us58wwmp 1081 20 pulses pulse NNS cord-015306-us58wwmp 1081 21 . . . cord-015306-us58wwmp 1082 1 Abstract abstract JJ cord-015306-us58wwmp 1082 2 # # NN cord-015306-us58wwmp 1082 3 P p NN cord-015306-us58wwmp 1082 4 - - HYPH cord-015306-us58wwmp 1082 5 SAT147 sat147 JJ cord-015306-us58wwmp 1082 6 Good good JJ cord-015306-us58wwmp 1082 7 outcome outcome NN cord-015306-us58wwmp 1082 8 of of IN cord-015306-us58wwmp 1082 9 biopsy biopsy NN cord-015306-us58wwmp 1082 10 - - HYPH cord-015306-us58wwmp 1082 11 proven prove VBN cord-015306-us58wwmp 1082 12 Henoch Henoch NNP cord-015306-us58wwmp 1082 13 - - HYPH cord-015306-us58wwmp 1082 14 Schonlein Schonlein NNP cord-015306-us58wwmp 1082 15 purpura purpura NN cord-015306-us58wwmp 1082 16 nephritis nephritis NN cord-015306-us58wwmp 1082 17 in in IN cord-015306-us58wwmp 1082 18 children child NNS cord-015306-us58wwmp 1082 19 in in IN cord-015306-us58wwmp 1083 1 Shanghai Shanghai NNP cord-015306-us58wwmp 1083 2 single single JJ cord-015306-us58wwmp 1083 3 center center NN cord-015306-us58wwmp 1083 4 Objective objective NN cord-015306-us58wwmp 1083 5 : : : cord-015306-us58wwmp 1084 1 Severe severe JJ cord-015306-us58wwmp 1084 2 HSP HSP NNP cord-015306-us58wwmp 1084 3 nephritis nephritis NN cord-015306-us58wwmp 1084 4 considered consider VBD cord-015306-us58wwmp 1084 5 a a DT cord-015306-us58wwmp 1084 6 risk risk NN cord-015306-us58wwmp 1084 7 factor factor NN cord-015306-us58wwmp 1084 8 for for IN cord-015306-us58wwmp 1084 9 chronic chronic JJ cord-015306-us58wwmp 1084 10 kidneys kidney NNS cord-015306-us58wwmp 1084 11 disease disease NN cord-015306-us58wwmp 1084 12 development development NN cord-015306-us58wwmp 1084 13 especially especially RB cord-015306-us58wwmp 1084 14 in in IN cord-015306-us58wwmp 1084 15 patients patient NNS cord-015306-us58wwmp 1084 16 with with IN cord-015306-us58wwmp 1084 17 nephrotic nephrotic JJ cord-015306-us58wwmp 1084 18 syndrome syndrome NN cord-015306-us58wwmp 1084 19 ( ( -LRB- cord-015306-us58wwmp 1084 20 NS NS NNP cord-015306-us58wwmp 1084 21 ) ) -RRB- cord-015306-us58wwmp 1084 22 . . . cord-015306-us58wwmp 1085 1 Methods method NNS cord-015306-us58wwmp 1085 2 : : : cord-015306-us58wwmp 1085 3 We -PRON- PRP cord-015306-us58wwmp 1085 4 present present VBP cord-015306-us58wwmp 1085 5 our -PRON- PRP$ cord-015306-us58wwmp 1085 6 experience experience NN cord-015306-us58wwmp 1085 7 with with IN cord-015306-us58wwmp 1085 8 tacrolimus tacrolimus NNP cord-015306-us58wwmp 1085 9 ( ( -LRB- cord-015306-us58wwmp 1085 10 Tac Tac NNP cord-015306-us58wwmp 1085 11 ) ) -RRB- cord-015306-us58wwmp 1085 12 as as IN cord-015306-us58wwmp 1085 13 a a DT cord-015306-us58wwmp 1085 14 steroid steroid NN cord-015306-us58wwmp 1085 15 sparing spare VBG cord-015306-us58wwmp 1085 16 agent agent NN cord-015306-us58wwmp 1085 17 for for IN cord-015306-us58wwmp 1085 18 a a DT cord-015306-us58wwmp 1085 19 treatment treatment NN cord-015306-us58wwmp 1085 20 of of IN cord-015306-us58wwmp 1085 21 severe severe JJ cord-015306-us58wwmp 1085 22 HSP HSP NNP cord-015306-us58wwmp 1085 23 nephritis nephritis NN cord-015306-us58wwmp 1085 24 in in IN cord-015306-us58wwmp 1085 25 17 17 CD cord-015306-us58wwmp 1085 26 years year NNS cord-015306-us58wwmp 1085 27 boy boy NN cord-015306-us58wwmp 1085 28 . . . cord-015306-us58wwmp 1086 1 Our -PRON- PRP$ cord-015306-us58wwmp 1086 2 patient patient NN cord-015306-us58wwmp 1086 3 has have VBZ cord-015306-us58wwmp 1086 4 been be VBN cord-015306-us58wwmp 1086 5 observing observe VBG cord-015306-us58wwmp 1086 6 at at IN cord-015306-us58wwmp 1086 7 the the DT cord-015306-us58wwmp 1086 8 Republic Republic NNP cord-015306-us58wwmp 1086 9 Center Center NNP cord-015306-us58wwmp 1086 10 of of IN cord-015306-us58wwmp 1086 11 Pediatric Pediatric NNP cord-015306-us58wwmp 1086 12 Nephrology Nephrology NNP cord-015306-us58wwmp 1086 13 Minsk Minsk NNP cord-015306-us58wwmp 1086 14 for for IN cord-015306-us58wwmp 1086 15 5 5 CD cord-015306-us58wwmp 1086 16 years year NNS cord-015306-us58wwmp 1086 17 . . . cord-015306-us58wwmp 1087 1 He -PRON- PRP cord-015306-us58wwmp 1087 2 presented present VBD cord-015306-us58wwmp 1087 3 with with IN cord-015306-us58wwmp 1087 4 a a DT cord-015306-us58wwmp 1087 5 typical typical JJ cord-015306-us58wwmp 1087 6 purpuric purpuric JJ cord-015306-us58wwmp 1087 7 rash rash NN cord-015306-us58wwmp 1087 8 with with IN cord-015306-us58wwmp 1087 9 recurrences recurrence NNS cord-015306-us58wwmp 1087 10 after after IN cord-015306-us58wwmp 1087 11 infections infection NNS cord-015306-us58wwmp 1087 12 . . . cord-015306-us58wwmp 1088 1 One one CD cord-015306-us58wwmp 1088 2 year year NN cord-015306-us58wwmp 1088 3 later later RB cord-015306-us58wwmp 1088 4 during during IN cord-015306-us58wwmp 1088 5 acute acute JJ cord-015306-us58wwmp 1088 6 pneumonia pneumonia NN cord-015306-us58wwmp 1088 7 macrohematuria macrohematuria NNP cord-015306-us58wwmp 1088 8 , , , cord-015306-us58wwmp 1088 9 proteinuria proteinuria NN cord-015306-us58wwmp 1088 10 ( ( -LRB- cord-015306-us58wwmp 1088 11 1 1 CD cord-015306-us58wwmp 1088 12 - - SYM cord-015306-us58wwmp 1088 13 1.5 1.5 CD cord-015306-us58wwmp 1088 14 g/24h g/24h NNP cord-015306-us58wwmp 1088 15 ) ) -RRB- cord-015306-us58wwmp 1089 1 occured occur VBD cord-015306-us58wwmp 1089 2 and and CC cord-015306-us58wwmp 1089 3 ACE ACE NNP cord-015306-us58wwmp 1089 4 inhibitors inhibitor NNS cord-015306-us58wwmp 1089 5 ( ( -LRB- cord-015306-us58wwmp 1089 6 iACE iace JJ cord-015306-us58wwmp 1089 7 ) ) -RRB- cord-015306-us58wwmp 1089 8 were be VBD cord-015306-us58wwmp 1089 9 prescribed prescribe VBN cord-015306-us58wwmp 1089 10 . . . cord-015306-us58wwmp 1090 1 Despite despite IN cord-015306-us58wwmp 1090 2 this this DT cord-015306-us58wwmp 1090 3 , , , cord-015306-us58wwmp 1090 4 boy boy NN cord-015306-us58wwmp 1090 5 developed develop VBN cord-015306-us58wwmp 1090 6 nephrotic nephrotic JJ cord-015306-us58wwmp 1090 7 range range NN cord-015306-us58wwmp 1090 8 proteinuria proteinuria NN cord-015306-us58wwmp 1090 9 ( ( -LRB- cord-015306-us58wwmp 1090 10 3.8 3.8 CD cord-015306-us58wwmp 1090 11 - - SYM cord-015306-us58wwmp 1090 12 7.7 7.7 CD cord-015306-us58wwmp 1090 13 g/24h g/24h NNP cord-015306-us58wwmp 1090 14 ) ) -RRB- cord-015306-us58wwmp 1090 15 , , . cord-015306-us58wwmp 1091 1 biochemical biochemical JJ cord-015306-us58wwmp 1091 2 protein protein NN cord-015306-us58wwmp 1091 3 52g 52g NNPS cord-015306-us58wwmp 1091 4 / / SYM cord-015306-us58wwmp 1091 5 l l NN cord-015306-us58wwmp 1091 6 , , , cord-015306-us58wwmp 1091 7 albumin albumin NN cord-015306-us58wwmp 1091 8 27g 27g NNP cord-015306-us58wwmp 1091 9 / / SYM cord-015306-us58wwmp 1091 10 l l NN cord-015306-us58wwmp 1091 11 , , , cord-015306-us58wwmp 1091 12 cholesterin cholesterin NNP cord-015306-us58wwmp 1092 1 6,5mmol 6,5mmol CD cord-015306-us58wwmp 1092 2 / / SYM cord-015306-us58wwmp 1092 3 l l NN cord-015306-us58wwmp 1092 4 . . . cord-015306-us58wwmp 1093 1 Renal renal JJ cord-015306-us58wwmp 1093 2 biopsie biopsie NN cord-015306-us58wwmp 1093 3 showed show VBD cord-015306-us58wwmp 1093 4 mesangial mesangial JJ cord-015306-us58wwmp 1093 5 proliferation proliferation NN cord-015306-us58wwmp 1093 6 with with IN cord-015306-us58wwmp 1093 7 IgA IgA NNP cord-015306-us58wwmp 1093 8 deposits deposit NNS cord-015306-us58wwmp 1093 9 . . . cord-015306-us58wwmp 1094 1 Prednisolon Prednisolon NNP cord-015306-us58wwmp 1094 2 ( ( -LRB- cord-015306-us58wwmp 1094 3 Pred Pred NNP cord-015306-us58wwmp 1094 4 ) ) -RRB- cord-015306-us58wwmp 1094 5 80 80 CD cord-015306-us58wwmp 1094 6 mg mg NN cord-015306-us58wwmp 1095 1 /daily /daily RB cord-015306-us58wwmp 1095 2 with with IN cord-015306-us58wwmp 1095 3 heparin heparin NN cord-015306-us58wwmp 1095 4 failed fail VBD cord-015306-us58wwmp 1095 5 to to TO cord-015306-us58wwmp 1095 6 decrease decrease VB cord-015306-us58wwmp 1095 7 proteinuria proteinuria NN cord-015306-us58wwmp 1095 8 and and CC cord-015306-us58wwmp 1095 9 activity activity NN cord-015306-us58wwmp 1095 10 . . . cord-015306-us58wwmp 1096 1 Cyclosporin Cyclosporin NNP cord-015306-us58wwmp 1096 2 A a DT cord-015306-us58wwmp 1096 3 200 200 CD cord-015306-us58wwmp 1096 4 mg mg NNP cord-015306-us58wwmp 1096 5 / / SYM cord-015306-us58wwmp 1096 6 daily daily RB cord-015306-us58wwmp 1096 7 plus plus CC cord-015306-us58wwmp 1096 8 Pred Pred NNP cord-015306-us58wwmp 1096 9 on on IN cord-015306-us58wwmp 1096 10 alternate alternate JJ cord-015306-us58wwmp 1096 11 day day NN cord-015306-us58wwmp 1096 12 were be VBD cord-015306-us58wwmp 1096 13 started start VBN cord-015306-us58wwmp 1096 14 and and CC cord-015306-us58wwmp 1096 15 followed follow VBN cord-015306-us58wwmp 1096 16 during during IN cord-015306-us58wwmp 1096 17 8 8 CD cord-015306-us58wwmp 1096 18 months month NNS cord-015306-us58wwmp 1096 19 with with IN cord-015306-us58wwmp 1096 20 positive positive JJ cord-015306-us58wwmp 1096 21 dynamic dynamic JJ cord-015306-us58wwmp 1096 22 ( ( -LRB- cord-015306-us58wwmp 1096 23 proteinuria proteinuria NN cord-015306-us58wwmp 1096 24 1,7g/24h 1,7g/24h CD cord-015306-us58wwmp 1096 25 , , , cord-015306-us58wwmp 1096 26 decreased decrease VBD cord-015306-us58wwmp 1096 27 clinical clinical JJ cord-015306-us58wwmp 1096 28 and and CC cord-015306-us58wwmp 1096 29 laboratory laboratory NN cord-015306-us58wwmp 1096 30 activity activity NN cord-015306-us58wwmp 1096 31 ) ) -RRB- cord-015306-us58wwmp 1096 32 after after IN cord-015306-us58wwmp 1096 33 which which WDT cord-015306-us58wwmp 1096 34 pathogenic pathogenic JJ cord-015306-us58wwmp 1096 35 treatment treatment NN cord-015306-us58wwmp 1096 36 was be VBD cord-015306-us58wwmp 1096 37 stopped stop VBN cord-015306-us58wwmp 1096 38 . . . cord-015306-us58wwmp 1097 1 Arterial arterial JJ cord-015306-us58wwmp 1097 2 hypertension hypertension NN cord-015306-us58wwmp 1097 3 ( ( -LRB- cord-015306-us58wwmp 1097 4 AG AG NNP cord-015306-us58wwmp 1097 5 ) ) -RRB- cord-015306-us58wwmp 1097 6 was be VBD cord-015306-us58wwmp 1097 7 treated treat VBN cord-015306-us58wwmp 1097 8 by by IN cord-015306-us58wwmp 1097 9 iACE iace NN cord-015306-us58wwmp 1097 10 . . . cord-015306-us58wwmp 1098 1 6 6 CD cord-015306-us58wwmp 1098 2 months month NNS cord-015306-us58wwmp 1098 3 later later RB cord-015306-us58wwmp 1098 4 proteinuria proteinuria NN cord-015306-us58wwmp 1098 5 ( ( -LRB- cord-015306-us58wwmp 1098 6 3.5g/24h 3.5g/24h CD cord-015306-us58wwmp 1098 7 ) ) -RRB- cord-015306-us58wwmp 1098 8 and and CC cord-015306-us58wwmp 1098 9 activity activity NN cord-015306-us58wwmp 1098 10 increased increase VBD cord-015306-us58wwmp 1098 11 again again RB cord-015306-us58wwmp 1098 12 . . . cord-015306-us58wwmp 1099 1 With with IN cord-015306-us58wwmp 1099 2 the the DT cord-015306-us58wwmp 1099 3 presence presence NN cord-015306-us58wwmp 1099 4 of of IN cord-015306-us58wwmp 1099 5 NS NS NNP cord-015306-us58wwmp 1099 6 resistance resistance NN cord-015306-us58wwmp 1099 7 to to IN cord-015306-us58wwmp 1099 8 steroids steroid NNS cord-015306-us58wwmp 1099 9 combined combine VBN cord-015306-us58wwmp 1099 10 with with IN cord-015306-us58wwmp 1099 11 hematuria hematuria NN cord-015306-us58wwmp 1099 12 and and CC cord-015306-us58wwmp 1099 13 AG AG NNP cord-015306-us58wwmp 1099 14 , , , cord-015306-us58wwmp 1099 15 medrol medrol NNP cord-015306-us58wwmp 1099 16 ( ( -LRB- cord-015306-us58wwmp 1099 17 64mg 64mg NNP cord-015306-us58wwmp 1099 18 / / SYM cord-015306-us58wwmp 1099 19 daily daily NN cord-015306-us58wwmp 1099 20 ) ) -RRB- cord-015306-us58wwmp 1099 21 plus plus CC cord-015306-us58wwmp 1099 22 Tac Tac NNP cord-015306-us58wwmp 1099 23 1 1 CD cord-015306-us58wwmp 1099 24 mg mg NNP cord-015306-us58wwmp 1099 25 twice twice RB cord-015306-us58wwmp 1099 26 daily daily RB cord-015306-us58wwmp 1099 27 were be VBD cord-015306-us58wwmp 1099 28 prescribed prescribe VBN cord-015306-us58wwmp 1099 29 . . . cord-015306-us58wwmp 1100 1 Duration duration NN cord-015306-us58wwmp 1100 2 of of IN cord-015306-us58wwmp 1100 3 Tac Tac NNP cord-015306-us58wwmp 1100 4 therapy therapy NN cord-015306-us58wwmp 1100 5 was be VBD cord-015306-us58wwmp 1100 6 5 5 CD cord-015306-us58wwmp 1100 7 months month NNS cord-015306-us58wwmp 1100 8 . . . cord-015306-us58wwmp 1101 1 Tac Tac NNP cord-015306-us58wwmp 1101 2 was be VBD cord-015306-us58wwmp 1101 3 succesfully succesfully RB cord-015306-us58wwmp 1101 4 withdrawn withdraw VBN cord-015306-us58wwmp 1101 5 with with IN cord-015306-us58wwmp 1101 6 no no DT cord-015306-us58wwmp 1101 7 rebound rebound NN cord-015306-us58wwmp 1101 8 disease disease NN cord-015306-us58wwmp 1101 9 activity activity NN cord-015306-us58wwmp 1101 10 observed observe VBD cord-015306-us58wwmp 1101 11 ( ( -LRB- cord-015306-us58wwmp 1101 12 during during IN cord-015306-us58wwmp 1101 13 9 9 CD cord-015306-us58wwmp 1101 14 months month NNS cord-015306-us58wwmp 1101 15 ) ) -RRB- cord-015306-us58wwmp 1101 16 . . . cord-015306-us58wwmp 1102 1 At at IN cord-015306-us58wwmp 1102 2 present present JJ cord-015306-us58wwmp 1102 3 the the DT cord-015306-us58wwmp 1102 4 patient patient NN cord-015306-us58wwmp 1102 5 receiving receive VBG cord-015306-us58wwmp 1102 6 iACE iace JJ cord-015306-us58wwmp 1102 7 only only RB cord-015306-us58wwmp 1102 8 . . . cord-015306-us58wwmp 1103 1 Our -PRON- PRP$ cord-015306-us58wwmp 1103 2 results result NNS cord-015306-us58wwmp 1103 3 indicate indicate VBP cord-015306-us58wwmp 1103 4 that that IN cord-015306-us58wwmp 1103 5 Tac Tac NNP cord-015306-us58wwmp 1103 6 may may MD cord-015306-us58wwmp 1103 7 be be VB cord-015306-us58wwmp 1103 8 a a DT cord-015306-us58wwmp 1103 9 promissing promissing JJ cord-015306-us58wwmp 1103 10 steroid steroid JJ cord-015306-us58wwmp 1103 11 sparing spare VBG cord-015306-us58wwmp 1103 12 agent agent NN cord-015306-us58wwmp 1103 13 for for IN cord-015306-us58wwmp 1103 14 treatment treatment NN cord-015306-us58wwmp 1103 15 of of IN cord-015306-us58wwmp 1103 16 severe severe JJ cord-015306-us58wwmp 1103 17 HSP HSP NNP cord-015306-us58wwmp 1103 18 nephritis nephritis NN cord-015306-us58wwmp 1103 19 . . . cord-015306-us58wwmp 1104 1 Anti anti JJ cord-015306-us58wwmp 1104 2 - - JJ cord-015306-us58wwmp 1104 3 proteinuric proteinuric JJ cord-015306-us58wwmp 1104 4 effect effect NN cord-015306-us58wwmp 1104 5 of of IN cord-015306-us58wwmp 1104 6 cyclosporine cyclosporine NN cord-015306-us58wwmp 1104 7 A a DT cord-015306-us58wwmp 1104 8 treatment treatment NN cord-015306-us58wwmp 1104 9 for for IN cord-015306-us58wwmp 1105 1 IgA IgA NNP cord-015306-us58wwmp 1105 2 deposit deposit NN cord-015306-us58wwmp 1105 3 diseases disease NNS cord-015306-us58wwmp 1105 4 Objective Objective NNP cord-015306-us58wwmp 1105 5 : : : cord-015306-us58wwmp 1105 6 To to TO cord-015306-us58wwmp 1105 7 evaluate evaluate VB cord-015306-us58wwmp 1105 8 the the DT cord-015306-us58wwmp 1105 9 therapeutic therapeutic JJ cord-015306-us58wwmp 1105 10 effect effect NN cord-015306-us58wwmp 1105 11 of of IN cord-015306-us58wwmp 1105 12 cyclosporine cyclosporine NN cord-015306-us58wwmp 1105 13 A a NN cord-015306-us58wwmp 1105 14 ( ( -LRB- cord-015306-us58wwmp 1105 15 CsA csa NN cord-015306-us58wwmp 1105 16 ) ) -RRB- cord-015306-us58wwmp 1105 17 on on IN cord-015306-us58wwmp 1105 18 nephrotic nephrotic JJ cord-015306-us58wwmp 1105 19 - - HYPH cord-015306-us58wwmp 1105 20 range range NN cord-015306-us58wwmp 1105 21 proteinuria proteinuria NN cord-015306-us58wwmp 1105 22 in in IN cord-015306-us58wwmp 1105 23 children child NNS cord-015306-us58wwmp 1105 24 with with IN cord-015306-us58wwmp 1105 25 Immunoglobulin Immunoglobulin NNP cord-015306-us58wwmp 1105 26 A A NNP cord-015306-us58wwmp 1105 27 ( ( -LRB- cord-015306-us58wwmp 1105 28 IgA IgA NNP cord-015306-us58wwmp 1105 29 ) ) -RRB- cord-015306-us58wwmp 1105 30 deposit deposit NN cord-015306-us58wwmp 1105 31 diseases disease NNS cord-015306-us58wwmp 1105 32 in in IN cord-015306-us58wwmp 1105 33 mesangium mesangium NN cord-015306-us58wwmp 1105 34 such such JJ cord-015306-us58wwmp 1105 35 as as IN cord-015306-us58wwmp 1105 36 IgA IgA NNP cord-015306-us58wwmp 1105 37 nephropathy nephropathy NNP cord-015306-us58wwmp 1105 38 ( ( -LRB- cord-015306-us58wwmp 1105 39 IgAN IgAN NNP cord-015306-us58wwmp 1105 40 ) ) -RRB- cord-015306-us58wwmp 1105 41 and and CC cord-015306-us58wwmp 1105 42 Henoch Henoch NNP cord-015306-us58wwmp 1105 43 - - HYPH cord-015306-us58wwmp 1105 44 Schonlein Schonlein NNP cord-015306-us58wwmp 1105 45 purpura purpura NN cord-015306-us58wwmp 1105 46 nephritis nephritis NN cord-015306-us58wwmp 1105 47 ( ( -LRB- cord-015306-us58wwmp 1105 48 HSPN HSPN NNP cord-015306-us58wwmp 1105 49 ) ) -RRB- cord-015306-us58wwmp 1105 50 . . . cord-015306-us58wwmp 1106 1 Methods method NNS cord-015306-us58wwmp 1106 2 : : : cord-015306-us58wwmp 1107 1 Fifty fifty CD cord-015306-us58wwmp 1107 2 four four CD cord-015306-us58wwmp 1107 3 children child NNS cord-015306-us58wwmp 1107 4 ( ( -LRB- cord-015306-us58wwmp 1107 5 36 36 CD cord-015306-us58wwmp 1107 6 children child NNS cord-015306-us58wwmp 1107 7 with with IN cord-015306-us58wwmp 1107 8 IgAN IgAN NNP cord-015306-us58wwmp 1107 9 , , , cord-015306-us58wwmp 1107 10 18 18 CD cord-015306-us58wwmp 1107 11 children child NNS cord-015306-us58wwmp 1107 12 with with IN cord-015306-us58wwmp 1107 13 HSPN HSPN NNP cord-015306-us58wwmp 1107 14 ) ) -RRB- cord-015306-us58wwmp 1107 15 who who WP cord-015306-us58wwmp 1107 16 were be VBD cord-015306-us58wwmp 1107 17 diagnosed diagnose VBN cord-015306-us58wwmp 1107 18 with with IN cord-015306-us58wwmp 1107 19 IgA IgA NNP cord-015306-us58wwmp 1107 20 deposit deposit NN cord-015306-us58wwmp 1107 21 diseases disease NNS cord-015306-us58wwmp 1107 22 in in IN cord-015306-us58wwmp 1107 23 mesangium mesangium NN cord-015306-us58wwmp 1107 24 at at IN cord-015306-us58wwmp 1107 25 renal renal JJ cord-015306-us58wwmp 1107 26 biopsy biopsy NNP cord-015306-us58wwmp 1107 27 were be VBD cord-015306-us58wwmp 1107 28 analyzed analyze VBN cord-015306-us58wwmp 1107 29 retrospectively retrospectively RB cord-015306-us58wwmp 1107 30 . . . cord-015306-us58wwmp 1108 1 All all PDT cord-015306-us58wwmp 1108 2 the the DT cord-015306-us58wwmp 1108 3 patients patient NNS cord-015306-us58wwmp 1108 4 developed develop VBD cord-015306-us58wwmp 1108 5 nephrotic nephrotic JJ cord-015306-us58wwmp 1108 6 - - HYPH cord-015306-us58wwmp 1108 7 range range NN cord-015306-us58wwmp 1108 8 proteinuria proteinuria NN cord-015306-us58wwmp 1108 9 ( ( -LRB- cord-015306-us58wwmp 1108 10 > > NFP cord-015306-us58wwmp 1108 11 40 40 CD cord-015306-us58wwmp 1108 12 mg mg NNP cord-015306-us58wwmp 1108 13 / / SYM cord-015306-us58wwmp 1108 14 m2 m2 NNP cord-015306-us58wwmp 1108 15 / / SYM cord-015306-us58wwmp 1108 16 day day NN cord-015306-us58wwmp 1108 17 ) ) -RRB- cord-015306-us58wwmp 1108 18 for for IN cord-015306-us58wwmp 1108 19 more more JJR cord-015306-us58wwmp 1108 20 than than IN cord-015306-us58wwmp 1108 21 3 3 CD cord-015306-us58wwmp 1108 22 months month NNS cord-015306-us58wwmp 1108 23 . . . cord-015306-us58wwmp 1109 1 The the DT cord-015306-us58wwmp 1109 2 starting starting NN cord-015306-us58wwmp 1109 3 dose dose NN cord-015306-us58wwmp 1109 4 of of IN cord-015306-us58wwmp 1109 5 CsA csa NN cord-015306-us58wwmp 1109 6 was be VBD cord-015306-us58wwmp 1109 7 5 5 CD cord-015306-us58wwmp 1109 8 mg mg NNP cord-015306-us58wwmp 1109 9 / / SYM cord-015306-us58wwmp 1109 10 kg kg NN cord-015306-us58wwmp 1109 11 per per IN cord-015306-us58wwmp 1109 12 day day NN cord-015306-us58wwmp 1109 13 that that WDT cord-015306-us58wwmp 1109 14 was be VBD cord-015306-us58wwmp 1109 15 given give VBN cord-015306-us58wwmp 1109 16 in in IN cord-015306-us58wwmp 1109 17 two two CD cord-015306-us58wwmp 1109 18 divided divide VBN cord-015306-us58wwmp 1109 19 doses dose NNS cord-015306-us58wwmp 1109 20 , , , cord-015306-us58wwmp 1109 21 and and CC cord-015306-us58wwmp 1109 22 the the DT cord-015306-us58wwmp 1109 23 drug drug NN cord-015306-us58wwmp 1109 24 level level NN cord-015306-us58wwmp 1109 25 was be VBD cord-015306-us58wwmp 1109 26 maintained maintain VBN cord-015306-us58wwmp 1110 1 between between IN cord-015306-us58wwmp 1110 2 100 100 CD cord-015306-us58wwmp 1110 3 and and CC cord-015306-us58wwmp 1110 4 200 200 CD cord-015306-us58wwmp 1110 5 ng ng NN cord-015306-us58wwmp 1110 6 / / SYM cord-015306-us58wwmp 1110 7 mL. ml. NN cord-015306-us58wwmp 1111 1 The the DT cord-015306-us58wwmp 1111 2 degree degree NN cord-015306-us58wwmp 1111 3 of of IN cord-015306-us58wwmp 1111 4 proteinuria proteinuria NN cord-015306-us58wwmp 1111 5 was be VBD cord-015306-us58wwmp 1111 6 measured measure VBN cord-015306-us58wwmp 1111 7 before before RB cord-015306-us58wwmp 1111 8 and and CC cord-015306-us58wwmp 1111 9 after after IN cord-015306-us58wwmp 1111 10 CsA csa NN cord-015306-us58wwmp 1111 11 treatment treatment NN cord-015306-us58wwmp 1111 12 . . . cord-015306-us58wwmp 1112 1 Steroids steroid NNS cord-015306-us58wwmp 1112 2 were be VBD cord-015306-us58wwmp 1112 3 tapered taper VBN cord-015306-us58wwmp 1112 4 off off RP cord-015306-us58wwmp 1112 5 and and CC cord-015306-us58wwmp 1112 6 stopped stop VBD cord-015306-us58wwmp 1112 7 gradually gradually RB cord-015306-us58wwmp 1112 8 after after IN cord-015306-us58wwmp 1112 9 initiation initiation NN cord-015306-us58wwmp 1112 10 of of IN cord-015306-us58wwmp 1112 11 CsA. CsA. NNP cord-015306-us58wwmp 1112 12 Results result NNS cord-015306-us58wwmp 1112 13 : : : cord-015306-us58wwmp 1112 14 Mean mean JJ cord-015306-us58wwmp 1112 15 duration duration NN cord-015306-us58wwmp 1112 16 of of IN cord-015306-us58wwmp 1112 17 CsA csa NN cord-015306-us58wwmp 1112 18 treatment treatment NN cord-015306-us58wwmp 1112 19 was be VBD cord-015306-us58wwmp 1112 20 10.7 10.7 CD cord-015306-us58wwmp 1112 21 + + CC cord-015306-us58wwmp 1112 22 /-5.6 /-5.6 NNP cord-015306-us58wwmp 1112 23 months month NNS cord-015306-us58wwmp 1112 24 ( ( -LRB- cord-015306-us58wwmp 1112 25 range range VBP cord-015306-us58wwmp 1112 26 1.4 1.4 CD cord-015306-us58wwmp 1112 27 -32.7 -32.7 CD cord-015306-us58wwmp 1112 28 months month NNS cord-015306-us58wwmp 1112 29 ) ) -RRB- cord-015306-us58wwmp 1112 30 . . . cord-015306-us58wwmp 1113 1 Mean mean JJ cord-015306-us58wwmp 1113 2 follow follow VB cord-015306-us58wwmp 1113 3 - - HYPH cord-015306-us58wwmp 1113 4 up up RP cord-015306-us58wwmp 1113 5 duration duration NN cord-015306-us58wwmp 1113 6 was be VBD cord-015306-us58wwmp 1113 7 3.7 3.7 CD cord-015306-us58wwmp 1113 8 + + CD cord-015306-us58wwmp 1114 1 /-3.1 /-3.1 . cord-015306-us58wwmp 1115 1 yr yr UH cord-015306-us58wwmp 1115 2 ( ( -LRB- cord-015306-us58wwmp 1115 3 range range VBP cord-015306-us58wwmp 1115 4 0.7 0.7 CD cord-015306-us58wwmp 1116 1 -15.2 -15.2 : cord-015306-us58wwmp 1116 2 yr yr NN cord-015306-us58wwmp 1116 3 ) ) -RRB- cord-015306-us58wwmp 1116 4 from from IN cord-015306-us58wwmp 1116 5 the the DT cord-015306-us58wwmp 1116 6 beginning beginning NN cord-015306-us58wwmp 1116 7 of of IN cord-015306-us58wwmp 1116 8 CsA csa NN cord-015306-us58wwmp 1116 9 treatment treatment NN cord-015306-us58wwmp 1116 10 . . . cord-015306-us58wwmp 1117 1 The the DT cord-015306-us58wwmp 1117 2 mean mean JJ cord-015306-us58wwmp 1117 3 ratios ratio NNS cord-015306-us58wwmp 1117 4 of of IN cord-015306-us58wwmp 1117 5 protein protein NN cord-015306-us58wwmp 1117 6 to to IN cord-015306-us58wwmp 1117 7 creatinine creatinine NN cord-015306-us58wwmp 1117 8 decreased decrease VBD cord-015306-us58wwmp 1117 9 from from IN cord-015306-us58wwmp 1117 10 3.7 3.7 CD cord-015306-us58wwmp 1117 11 + + CC cord-015306-us58wwmp 1117 12 /-1.5 /-1.5 . cord-015306-us58wwmp 1118 1 to to IN cord-015306-us58wwmp 1118 2 0.6 0.6 CD cord-015306-us58wwmp 1118 3 + + CC cord-015306-us58wwmp 1118 4 /-0.4 /-0.4 . cord-015306-us58wwmp 1118 5 after after IN cord-015306-us58wwmp 1118 6 CsA csa NN cord-015306-us58wwmp 1118 7 treatment treatment NN cord-015306-us58wwmp 1118 8 for for IN cord-015306-us58wwmp 1118 9 12 12 CD cord-015306-us58wwmp 1118 10 months month NNS cord-015306-us58wwmp 1118 11 . . . cord-015306-us58wwmp 1119 1 Thirty thirty CD cord-015306-us58wwmp 1119 2 - - HYPH cord-015306-us58wwmp 1119 3 two two CD cord-015306-us58wwmp 1119 4 ( ( -LRB- cord-015306-us58wwmp 1119 5 59.2 59.2 CD cord-015306-us58wwmp 1119 6 % % NN cord-015306-us58wwmp 1119 7 ) ) -RRB- cord-015306-us58wwmp 1119 8 patients patient NNS cord-015306-us58wwmp 1119 9 achieved achieve VBD cord-015306-us58wwmp 1119 10 complete complete JJ cord-015306-us58wwmp 1119 11 remission remission NN cord-015306-us58wwmp 1119 12 . . . cord-015306-us58wwmp 1120 1 Renal renal JJ cord-015306-us58wwmp 1120 2 function function NN cord-015306-us58wwmp 1120 3 was be VBD cord-015306-us58wwmp 1120 4 preserved preserve VBN cord-015306-us58wwmp 1120 5 in in IN cord-015306-us58wwmp 1120 6 all all DT cord-015306-us58wwmp 1120 7 patients patient NNS cord-015306-us58wwmp 1120 8 12 12 CD cord-015306-us58wwmp 1120 9 months month NNS cord-015306-us58wwmp 1120 10 after after IN cord-015306-us58wwmp 1120 11 CsA csa NN cord-015306-us58wwmp 1120 12 treatment treatment NN cord-015306-us58wwmp 1120 13 . . . cord-015306-us58wwmp 1121 1 There there EX cord-015306-us58wwmp 1121 2 were be VBD cord-015306-us58wwmp 1121 3 no no DT cord-015306-us58wwmp 1121 4 severe severe JJ cord-015306-us58wwmp 1121 5 complications complication NNS cord-015306-us58wwmp 1121 6 in in IN cord-015306-us58wwmp 1121 7 patients patient NNS cord-015306-us58wwmp 1121 8 with with IN cord-015306-us58wwmp 1121 9 CsA csa NN cord-015306-us58wwmp 1121 10 treatment treatment NN cord-015306-us58wwmp 1121 11 . . . cord-015306-us58wwmp 1122 1 Conclusion conclusion NN cord-015306-us58wwmp 1122 2 : : : cord-015306-us58wwmp 1123 1 Our -PRON- PRP$ cord-015306-us58wwmp 1123 2 findings finding NNS cord-015306-us58wwmp 1123 3 indicate indicate VBP cord-015306-us58wwmp 1123 4 that that IN cord-015306-us58wwmp 1123 5 CsA CsA NNP cord-015306-us58wwmp 1123 6 is be VBZ cord-015306-us58wwmp 1123 7 an an DT cord-015306-us58wwmp 1123 8 effective effective JJ cord-015306-us58wwmp 1123 9 agent agent NN cord-015306-us58wwmp 1123 10 to to TO cord-015306-us58wwmp 1123 11 treat treat VB cord-015306-us58wwmp 1123 12 nephrotic nephrotic JJ cord-015306-us58wwmp 1123 13 - - HYPH cord-015306-us58wwmp 1123 14 range range NN cord-015306-us58wwmp 1123 15 proteinuria proteinuria NN cord-015306-us58wwmp 1123 16 of of IN cord-015306-us58wwmp 1123 17 IgA IgA NNP cord-015306-us58wwmp 1123 18 deposition deposition NN cord-015306-us58wwmp 1123 19 glomerular glomerular JJ cord-015306-us58wwmp 1123 20 diseases disease NNS cord-015306-us58wwmp 1123 21 such such JJ cord-015306-us58wwmp 1123 22 as as IN cord-015306-us58wwmp 1123 23 IgAN IgAN NNP cord-015306-us58wwmp 1123 24 and and CC cord-015306-us58wwmp 1123 25 HSPN HSPN NNP cord-015306-us58wwmp 1123 26 and and CC cord-015306-us58wwmp 1123 27 the the DT cord-015306-us58wwmp 1123 28 duration duration NN cord-015306-us58wwmp 1123 29 of of IN cord-015306-us58wwmp 1123 30 CsA csa NN cord-015306-us58wwmp 1123 31 treatment treatment NN cord-015306-us58wwmp 1123 32 should should MD cord-015306-us58wwmp 1123 33 be be VB cord-015306-us58wwmp 1123 34 at at RB cord-015306-us58wwmp 1123 35 least least JJS cord-015306-us58wwmp 1123 36 more more JJR cord-015306-us58wwmp 1123 37 than than IN cord-015306-us58wwmp 1123 38 3 3 CD cord-015306-us58wwmp 1123 39 months month NNS cord-015306-us58wwmp 1123 40 for for IN cord-015306-us58wwmp 1123 41 efficacy efficacy NN cord-015306-us58wwmp 1123 42 . . . cord-015306-us58wwmp 1124 1 Objective objective NN cord-015306-us58wwmp 1124 2 : : : cord-015306-us58wwmp 1124 3 To to TO cord-015306-us58wwmp 1124 4 observe observe VB cord-015306-us58wwmp 1124 5 the the DT cord-015306-us58wwmp 1124 6 therapeutic therapeutic JJ cord-015306-us58wwmp 1124 7 effects effect NNS cord-015306-us58wwmp 1124 8 of of IN cord-015306-us58wwmp 1124 9 hemoperfusion hemoperfusion NN cord-015306-us58wwmp 1124 10 combined combine VBN cord-015306-us58wwmp 1124 11 with with IN cord-015306-us58wwmp 1124 12 corticosteroid corticosteroid NN cord-015306-us58wwmp 1124 13 in in IN cord-015306-us58wwmp 1124 14 treating treat VBG cord-015306-us58wwmp 1124 15 children child NNS cord-015306-us58wwmp 1124 16 with with IN cord-015306-us58wwmp 1124 17 Henoch Henoch NNP cord-015306-us58wwmp 1124 18 - - HYPH cord-015306-us58wwmp 1124 19 Schonlein Schonlein NNP cord-015306-us58wwmp 1124 20 purpura purpura NN cord-015306-us58wwmp 1124 21 . . . cord-015306-us58wwmp 1125 1 Methods method NNS cord-015306-us58wwmp 1125 2 : : : cord-015306-us58wwmp 1126 1 A a DT cord-015306-us58wwmp 1126 2 total total NN cord-015306-us58wwmp 1126 3 of of IN cord-015306-us58wwmp 1126 4 180 180 CD cord-015306-us58wwmp 1126 5 patients patient NNS cord-015306-us58wwmp 1126 6 ( ( -LRB- cord-015306-us58wwmp 1126 7 101 101 CD cord-015306-us58wwmp 1126 8 inthe inthe NNP cord-015306-us58wwmp 1126 9 hemoperfusion hemoperfusion NN cord-015306-us58wwmp 1126 10 group group NN cord-015306-us58wwmp 1126 11 ( ( -LRB- cord-015306-us58wwmp 1126 12 HP HP NNP cord-015306-us58wwmp 1126 13 ) ) -RRB- cord-015306-us58wwmp 1127 1 and79 and79 . cord-015306-us58wwmp 1128 1 inthe inthe NNP cord-015306-us58wwmp 1128 2 control control NNP cord-015306-us58wwmp 1128 3 group group NN cord-015306-us58wwmp 1128 4 ) ) -RRB- cord-015306-us58wwmp 1128 5 were be VBD cord-015306-us58wwmp 1128 6 included include VBN cord-015306-us58wwmp 1128 7 and and CC cord-015306-us58wwmp 1128 8 followed follow VBN cord-015306-us58wwmp 1128 9 up up RP cord-015306-us58wwmp 1128 10 for for IN cord-015306-us58wwmp 1128 11 12 12 CD cord-015306-us58wwmp 1128 12 months month NNS cord-015306-us58wwmp 1128 13 . . . cord-015306-us58wwmp 1129 1 Both both DT cord-015306-us58wwmp 1129 2 groups group NNS cord-015306-us58wwmp 1129 3 were be VBD cord-015306-us58wwmp 1129 4 treated treat VBN cord-015306-us58wwmp 1129 5 with with IN cord-015306-us58wwmp 1129 6 corticosteroids corticosteroid NNS cord-015306-us58wwmp 1129 7 and and CC cord-015306-us58wwmp 1129 8 other other JJ cord-015306-us58wwmp 1129 9 supportive supportive JJ cord-015306-us58wwmp 1129 10 therapy therapy NN cord-015306-us58wwmp 1129 11 . . . cord-015306-us58wwmp 1130 1 Patients patient NNS cord-015306-us58wwmp 1130 2 in in IN cord-015306-us58wwmp 1130 3 the the DT cord-015306-us58wwmp 1130 4 HP HP NNP cord-015306-us58wwmp 1130 5 group group NN cord-015306-us58wwmp 1130 6 received receive VBD cord-015306-us58wwmp 1130 7 2 2 CD cord-015306-us58wwmp 1130 8 hours hour NNS cord-015306-us58wwmp 1130 9 of of IN cord-015306-us58wwmp 1130 10 hemoperfusion hemoperfusion NN cord-015306-us58wwmp 1130 11 each each DT cord-015306-us58wwmp 1130 12 day day NN cord-015306-us58wwmp 1130 13 for for IN cord-015306-us58wwmp 1130 14 3 3 CD cord-015306-us58wwmp 1130 15 consecutive consecutive JJ cord-015306-us58wwmp 1130 16 days day NNS cord-015306-us58wwmp 1130 17 . . . cord-015306-us58wwmp 1131 1 Clinical clinical JJ cord-015306-us58wwmp 1131 2 features feature NNS cord-015306-us58wwmp 1131 3 at at IN cord-015306-us58wwmp 1131 4 the the DT cord-015306-us58wwmp 1131 5 acute acute JJ cord-015306-us58wwmp 1131 6 phase phase NN cord-015306-us58wwmp 1131 7 , , , cord-015306-us58wwmp 1131 8 relapses relapse NNS cord-015306-us58wwmp 1131 9 in in IN cord-015306-us58wwmp 1131 10 a a DT cord-015306-us58wwmp 1131 11 year year NN cord-015306-us58wwmp 1131 12 and and CC cord-015306-us58wwmp 1131 13 renal renal JJ cord-015306-us58wwmp 1131 14 involvement involvement NN cord-015306-us58wwmp 1131 15 at at IN cord-015306-us58wwmp 1131 16 1 1 CD cord-015306-us58wwmp 1131 17 , , , cord-015306-us58wwmp 1131 18 3 3 CD cord-015306-us58wwmp 1131 19 , , , cord-015306-us58wwmp 1131 20 6 6 CD cord-015306-us58wwmp 1131 21 , , , cord-015306-us58wwmp 1131 22 12 12 CD cord-015306-us58wwmp 1131 23 months month NNS cord-015306-us58wwmp 1131 24 were be VBD cord-015306-us58wwmp 1131 25 compared compare VBN cord-015306-us58wwmp 1131 26 . . . cord-015306-us58wwmp 1132 1 The the DT cord-015306-us58wwmp 1132 2 blood blood NN cord-015306-us58wwmp 1132 3 levels level NNS cord-015306-us58wwmp 1132 4 of of IN cord-015306-us58wwmp 1132 5 IgA IgA NNP cord-015306-us58wwmp 1132 6 and and CC cord-015306-us58wwmp 1132 7 such such JJ cord-015306-us58wwmp 1132 8 cytokines cytokine NNS cord-015306-us58wwmp 1132 9 as as IN cord-015306-us58wwmp 1132 10 , , , cord-015306-us58wwmp 1132 11 TNF tnf NN cord-015306-us58wwmp 1132 12 - - HYPH cord-015306-us58wwmp 1132 13 alpha alpha NN cord-015306-us58wwmp 1132 14 - - HYPH cord-015306-us58wwmp 1132 15 IL-1 IL-1 NNP cord-015306-us58wwmp 1132 16 , , , cord-015306-us58wwmp 1132 17 IL-6 IL-6 NNP cord-015306-us58wwmp 1132 18 , , , cord-015306-us58wwmp 1132 19 LTB4 LTB4 NNP cord-015306-us58wwmp 1132 20 were be VBD cord-015306-us58wwmp 1132 21 measured measure VBN cord-015306-us58wwmp 1132 22 by by IN cord-015306-us58wwmp 1132 23 ELISA ELISA NNP cord-015306-us58wwmp 1132 24 technique technique NN cord-015306-us58wwmp 1132 25 before before RB cord-015306-us58wwmp 1132 26 and and CC cord-015306-us58wwmp 1132 27 1 1 CD cord-015306-us58wwmp 1132 28 , , , cord-015306-us58wwmp 1132 29 2 2 CD cord-015306-us58wwmp 1132 30 , , , cord-015306-us58wwmp 1132 31 3 3 CD cord-015306-us58wwmp 1132 32 days day NNS cord-015306-us58wwmp 1132 33 after after IN cord-015306-us58wwmp 1132 34 hemoperfusion hemoperfusion NN cord-015306-us58wwmp 1132 35 . . . cord-015306-us58wwmp 1133 1 Results result NNS cord-015306-us58wwmp 1133 2 : : : cord-015306-us58wwmp 1134 1 Hemoperfusion Hemoperfusion NNP cord-015306-us58wwmp 1134 2 significantly significantly RB cord-015306-us58wwmp 1134 3 reduced reduce VBD cord-015306-us58wwmp 1134 4 the the DT cord-015306-us58wwmp 1134 5 severity severity NN cord-015306-us58wwmp 1134 6 and and CC cord-015306-us58wwmp 1134 7 duration duration NN cord-015306-us58wwmp 1134 8 of of IN cord-015306-us58wwmp 1134 9 abdominal abdominal JJ cord-015306-us58wwmp 1134 10 and and CC cord-015306-us58wwmp 1134 11 joint joint JJ cord-015306-us58wwmp 1134 12 pains pain NNS cord-015306-us58wwmp 1134 13 . . . cord-015306-us58wwmp 1135 1 For for IN cord-015306-us58wwmp 1135 2 patients patient NNS cord-015306-us58wwmp 1135 3 with with IN cord-015306-us58wwmp 1135 4 renal renal JJ cord-015306-us58wwmp 1135 5 involvement involvement NN cord-015306-us58wwmp 1135 6 at at IN cord-015306-us58wwmp 1135 7 acute acute JJ cord-015306-us58wwmp 1135 8 phase phase NN cord-015306-us58wwmp 1135 9 the the DT cord-015306-us58wwmp 1135 10 HP HP NNP cord-015306-us58wwmp 1135 11 group group NN cord-015306-us58wwmp 1135 12 had have VBD cord-015306-us58wwmp 1135 13 quicker quick JJR cord-015306-us58wwmp 1135 14 relief relief NN cord-015306-us58wwmp 1135 15 than than IN cord-015306-us58wwmp 1135 16 the the DT cord-015306-us58wwmp 1135 17 control control NN cord-015306-us58wwmp 1135 18 ( ( -LRB- cord-015306-us58wwmp 1135 19 log log NN cord-015306-us58wwmp 1135 20 rank rank NN cord-015306-us58wwmp 1135 21 P=0.000 P=0.000 NNP cord-015306-us58wwmp 1135 22 ) ) -RRB- cord-015306-us58wwmp 1135 23 . . . cord-015306-us58wwmp 1136 1 For for IN cord-015306-us58wwmp 1136 2 patients patient NNS cord-015306-us58wwmp 1136 3 without without IN cord-015306-us58wwmp 1136 4 renal renal JJ cord-015306-us58wwmp 1136 5 involvement involvement NN cord-015306-us58wwmp 1136 6 at at IN cord-015306-us58wwmp 1136 7 acute acute JJ cord-015306-us58wwmp 1136 8 phase phase NN cord-015306-us58wwmp 1136 9 the the DT cord-015306-us58wwmp 1136 10 HP HP NNP cord-015306-us58wwmp 1136 11 group group NN cord-015306-us58wwmp 1136 12 had have VBD cord-015306-us58wwmp 1136 13 less less JJR cord-015306-us58wwmp 1136 14 occurrences occurrence NNS cord-015306-us58wwmp 1136 15 of of IN cord-015306-us58wwmp 1136 16 renal renal JJ cord-015306-us58wwmp 1136 17 involvement involvement NN cord-015306-us58wwmp 1136 18 compared compare VBN cord-015306-us58wwmp 1136 19 with with IN cord-015306-us58wwmp 1136 20 the the DT cord-015306-us58wwmp 1136 21 control control NN cord-015306-us58wwmp 1136 22 during during IN cord-015306-us58wwmp 1136 23 follow follow NN cord-015306-us58wwmp 1136 24 - - HYPH cord-015306-us58wwmp 1136 25 ups(log ups(log CD cord-015306-us58wwmp 1136 26 rank rank NN cord-015306-us58wwmp 1136 27 P=0.001 P=0.001 NNP cord-015306-us58wwmp 1136 28 ) ) -RRB- cord-015306-us58wwmp 1136 29 . . . cord-015306-us58wwmp 1137 1 The the DT cord-015306-us58wwmp 1137 2 rash rash NN cord-015306-us58wwmp 1137 3 was be VBD cord-015306-us58wwmp 1137 4 also also RB cord-015306-us58wwmp 1137 5 alleviated alleviate VBN cord-015306-us58wwmp 1137 6 after after IN cord-015306-us58wwmp 1137 7 hemoperfusion hemoperfusion NN cord-015306-us58wwmp 1137 8 though though IN cord-015306-us58wwmp 1137 9 the the DT cord-015306-us58wwmp 1137 10 difference difference NN cord-015306-us58wwmp 1137 11 was be VBD cord-015306-us58wwmp 1137 12 not not RB cord-015306-us58wwmp 1137 13 significant significant JJ cord-015306-us58wwmp 1137 14 . . . cord-015306-us58wwmp 1138 1 Patients patient NNS cord-015306-us58wwmp 1138 2 ' ' POS cord-015306-us58wwmp 1138 3 levels level NNS cord-015306-us58wwmp 1138 4 of of IN cord-015306-us58wwmp 1138 5 IgA IgA NNP cord-015306-us58wwmp 1138 6 were be VBD cord-015306-us58wwmp 1138 7 elevated elevate VBN cord-015306-us58wwmp 1138 8 compared compare VBN cord-015306-us58wwmp 1138 9 with with IN cord-015306-us58wwmp 1138 10 the the DT cord-015306-us58wwmp 1138 11 healthy healthy JJ cord-015306-us58wwmp 1138 12 control control NN cord-015306-us58wwmp 1138 13 before before IN cord-015306-us58wwmp 1138 14 treatment treatment NN cord-015306-us58wwmp 1139 1 ( ( -LRB- cord-015306-us58wwmp 1139 2 day0 day0 NN cord-015306-us58wwmp 1139 3 ) ) -RRB- cord-015306-us58wwmp 1139 4 Patients'levels patients'level NNS cord-015306-us58wwmp 1139 5 of of IN cord-015306-us58wwmp 1139 6 cytokines cytokine NNS cord-015306-us58wwmp 1139 7 also also RB cord-015306-us58wwmp 1139 8 significantly significantly RB cord-015306-us58wwmp 1139 9 increased increase VBD cord-015306-us58wwmp 1139 10 compared compare VBN cord-015306-us58wwmp 1139 11 with with IN cord-015306-us58wwmp 1139 12 the the DT cord-015306-us58wwmp 1139 13 healthy healthy JJ cord-015306-us58wwmp 1139 14 control control NN cord-015306-us58wwmp 1139 15 on on IN cord-015306-us58wwmp 1139 16 day0 day0 NN cord-015306-us58wwmp 1139 17 , , , cord-015306-us58wwmp 1139 18 they -PRON- PRP cord-015306-us58wwmp 1139 19 began begin VBD cord-015306-us58wwmp 1139 20 to to TO cord-015306-us58wwmp 1139 21 decrease decrease VB cord-015306-us58wwmp 1139 22 1 1 CD cord-015306-us58wwmp 1139 23 day day NN cord-015306-us58wwmp 1139 24 after after IN cord-015306-us58wwmp 1139 25 hemoperfusion hemoperfusion NN cord-015306-us58wwmp 1139 26 and and CC cord-015306-us58wwmp 1139 27 there there EX cord-015306-us58wwmp 1139 28 were be VBD cord-015306-us58wwmp 1139 29 significant significant JJ cord-015306-us58wwmp 1139 30 differences difference NNS cord-015306-us58wwmp 1139 31 among among IN cord-015306-us58wwmp 1139 32 those those DT cord-015306-us58wwmp 1139 33 groups group NNS cord-015306-us58wwmp 1139 34 . . . cord-015306-us58wwmp 1140 1 Less Less JJR cord-015306-us58wwmp 1140 2 relapses relapse NNS cord-015306-us58wwmp 1140 3 were be VBD cord-015306-us58wwmp 1140 4 seen see VBN cord-015306-us58wwmp 1140 5 in in IN cord-015306-us58wwmp 1140 6 the the DT cord-015306-us58wwmp 1140 7 HP HP NNP cord-015306-us58wwmp 1140 8 group group NN cord-015306-us58wwmp 1140 9 compared compare VBN cord-015306-us58wwmp 1140 10 with with IN cord-015306-us58wwmp 1140 11 the the DT cord-015306-us58wwmp 1140 12 control control NN cord-015306-us58wwmp 1140 13 ( ( -LRB- cord-015306-us58wwmp 1140 14 P=0.011 P=0.011 NNP cord-015306-us58wwmp 1140 15 ) ) -RRB- cord-015306-us58wwmp 1140 16 . . . cord-015306-us58wwmp 1141 1 Conclusion conclusion NN cord-015306-us58wwmp 1141 2 : : : cord-015306-us58wwmp 1141 3 Hemoperfusion hemoperfusion NN cord-015306-us58wwmp 1141 4 combined combine VBN cord-015306-us58wwmp 1141 5 with with IN cord-015306-us58wwmp 1141 6 corticosteroid corticosteroid NN cord-015306-us58wwmp 1141 7 was be VBD cord-015306-us58wwmp 1141 8 more more RBR cord-015306-us58wwmp 1141 9 effective effective JJ cord-015306-us58wwmp 1141 10 than than IN cord-015306-us58wwmp 1141 11 corticosteroid corticosteroid NN cord-015306-us58wwmp 1141 12 alone alone RB cord-015306-us58wwmp 1141 13 in in IN cord-015306-us58wwmp 1141 14 improving improve VBG cord-015306-us58wwmp 1141 15 extrarenal extrarenal JJ cord-015306-us58wwmp 1141 16 symptoms symptom NNS cord-015306-us58wwmp 1141 17 , , , cord-015306-us58wwmp 1141 18 alleviating alleviate VBG cord-015306-us58wwmp 1141 19 and and CC cord-015306-us58wwmp 1141 20 preventing prevent VBG cord-015306-us58wwmp 1141 21 renal renal JJ cord-015306-us58wwmp 1141 22 involvement involvement NN cord-015306-us58wwmp 1141 23 . . . cord-015306-us58wwmp 1142 1 The the DT cord-015306-us58wwmp 1142 2 effects effect NNS cord-015306-us58wwmp 1142 3 may may MD cord-015306-us58wwmp 1142 4 be be VB cord-015306-us58wwmp 1142 5 achieved achieve VBN cord-015306-us58wwmp 1142 6 by by IN cord-015306-us58wwmp 1142 7 IgA IgA NNP cord-015306-us58wwmp 1142 8 and and CC cord-015306-us58wwmp 1142 9 cytokine cytokine JJ cord-015306-us58wwmp 1142 10 reduction reduction NN cord-015306-us58wwmp 1142 11 after after IN cord-015306-us58wwmp 1142 12 hemoperfusion hemoperfusion NN cord-015306-us58wwmp 1142 13 . . . cord-015306-us58wwmp 1143 1 The the DT cord-015306-us58wwmp 1143 2 treatment treatment NN cord-015306-us58wwmp 1143 3 of of IN cord-015306-us58wwmp 1143 4 Henoch Henoch NNP cord-015306-us58wwmp 1143 5 - - HYPH cord-015306-us58wwmp 1143 6 Schonlein Schonlein NNP cord-015306-us58wwmp 1143 7 purpura purpura NN cord-015306-us58wwmp 1143 8 nephritis nephritis NN cord-015306-us58wwmp 1143 9 in in IN cord-015306-us58wwmp 1143 10 children child NNS cord-015306-us58wwmp 1143 11 combined combine VBN cord-015306-us58wwmp 1143 12 with with IN cord-015306-us58wwmp 1143 13 mycophenolate mycophenolate NNP cord-015306-us58wwmp 1143 14 mofetil mofetil NNP cord-015306-us58wwmp 1143 15 and and CC cord-015306-us58wwmp 1143 16 corticosteroid corticosteroid NNP cord-015306-us58wwmp 1143 17 _SP cord-015306-us58wwmp 1143 18 nephritic nephritic NNP cord-015306-us58wwmp 1143 19 syndrome syndrome NN cord-015306-us58wwmp 1143 20 type type NN cord-015306-us58wwmp 1143 21 , , , cord-015306-us58wwmp 1143 22 13 13 CD cord-015306-us58wwmp 1143 23 cases(39.4 cases(39.4 NNP cord-015306-us58wwmp 1143 24 % % NN cord-015306-us58wwmp 1143 25 ) ) -RRB- cord-015306-us58wwmp 1143 26 . . . cord-015306-us58wwmp 1144 1 About about IN cord-015306-us58wwmp 1144 2 histological histological JJ cord-015306-us58wwmp 1144 3 degrees degree NNS cord-015306-us58wwmp 1144 4 , , , cord-015306-us58wwmp 1144 5 32 32 CD cord-015306-us58wwmp 1144 6 cases case NNS cord-015306-us58wwmp 1144 7 were be VBD cord-015306-us58wwmp 1144 8 in in IN cord-015306-us58wwmp 1144 9 grade grade NN cord-015306-us58wwmp 1144 10 3 3 CD cord-015306-us58wwmp 1144 11 ( ( -LRB- cord-015306-us58wwmp 1144 12 mesangial mesangial JJ cord-015306-us58wwmp 1144 13 proliferation proliferation NN cord-015306-us58wwmp 1144 14 , , , cord-015306-us58wwmp 1144 15 all all DT cord-015306-us58wwmp 1144 16 accompanied accompany VBN cord-015306-us58wwmp 1144 17 by by IN cord-015306-us58wwmp 1144 18 < < XX cord-015306-us58wwmp 1144 19 50 50 CD cord-015306-us58wwmp 1144 20 % % NN cord-015306-us58wwmp 1144 21 crescent crescent NN cord-015306-us58wwmp 1144 22 formation formation NN cord-015306-us58wwmp 1144 23 ) ) -RRB- cord-015306-us58wwmp 1144 24 , , , cord-015306-us58wwmp 1144 25 1 1 CD cord-015306-us58wwmp 1144 26 case case NN cord-015306-us58wwmp 1144 27 was be VBD cord-015306-us58wwmp 1144 28 in in IN cord-015306-us58wwmp 1144 29 grade grade NN cord-015306-us58wwmp 1144 30 5 5 CD cord-015306-us58wwmp 1144 31 ( ( -LRB- cord-015306-us58wwmp 1144 32 moderate moderate JJ cord-015306-us58wwmp 1144 33 to to IN cord-015306-us58wwmp 1144 34 severe severe JJ cord-015306-us58wwmp 1144 35 mesangial mesangial JJ cord-015306-us58wwmp 1144 36 proliferation proliferation NN cord-015306-us58wwmp 1144 37 , , , cord-015306-us58wwmp 1144 38 accompanied accompany VBN cord-015306-us58wwmp 1144 39 by by IN cord-015306-us58wwmp 1144 40 88 88 CD cord-015306-us58wwmp 1144 41 % % NN cord-015306-us58wwmp 1144 42 crescent crescent NN cord-015306-us58wwmp 1144 43 formation formation NN cord-015306-us58wwmp 1144 44 ) ) -RRB- cord-015306-us58wwmp 1144 45 . . . cord-015306-us58wwmp 1145 1 Treated treat VBN cord-015306-us58wwmp 1145 2 with with IN cord-015306-us58wwmp 1145 3 new new JJ cord-015306-us58wwmp 1145 4 therapy therapy NN cord-015306-us58wwmp 1145 5 , , , cord-015306-us58wwmp 1145 6 30 30 CD cord-015306-us58wwmp 1145 7 cases case NNS cord-015306-us58wwmp 1145 8 were be VBD cord-015306-us58wwmp 1145 9 complete complete JJ cord-015306-us58wwmp 1145 10 remission remission NN cord-015306-us58wwmp 1145 11 ( ( -LRB- cord-015306-us58wwmp 1145 12 91 91 CD cord-015306-us58wwmp 1145 13 % % NN cord-015306-us58wwmp 1145 14 ) ) -RRB- cord-015306-us58wwmp 1145 15 , , , cord-015306-us58wwmp 1145 16 2 2 CD cord-015306-us58wwmp 1145 17 cases case NNS cord-015306-us58wwmp 1145 18 were be VBD cord-015306-us58wwmp 1145 19 improved improve VBN cord-015306-us58wwmp 1145 20 , , , cord-015306-us58wwmp 1145 21 and and CC cord-015306-us58wwmp 1145 22 one one CD cord-015306-us58wwmp 1145 23 died die VBD cord-015306-us58wwmp 1145 24 . . . cord-015306-us58wwmp 1146 1 The the DT cord-015306-us58wwmp 1146 2 complete complete JJ cord-015306-us58wwmp 1146 3 remission remission NN cord-015306-us58wwmp 1146 4 rate rate NN cord-015306-us58wwmp 1146 5 of of IN cord-015306-us58wwmp 1146 6 this this DT cord-015306-us58wwmp 1146 7 therapy therapy NN cord-015306-us58wwmp 1146 8 was be VBD cord-015306-us58wwmp 1146 9 significantly significantly RB cord-015306-us58wwmp 1146 10 higher high JJR cord-015306-us58wwmp 1146 11 than than IN cord-015306-us58wwmp 1146 12 that that DT cord-015306-us58wwmp 1146 13 of of IN cord-015306-us58wwmp 1146 14 the the DT cord-015306-us58wwmp 1146 15 past past JJ cord-015306-us58wwmp 1146 16 treatment treatment NN cord-015306-us58wwmp 1146 17 . . . cord-015306-us58wwmp 1147 1 Objective objective NN cord-015306-us58wwmp 1147 2 : : : cord-015306-us58wwmp 1148 1 Steroid steroid JJ cord-015306-us58wwmp 1148 2 pulse pulse NN cord-015306-us58wwmp 1148 3 therapy therapy NN cord-015306-us58wwmp 1148 4 ( ( -LRB- cord-015306-us58wwmp 1148 5 SPT SPT NNP cord-015306-us58wwmp 1148 6 ) ) -RRB- cord-015306-us58wwmp 1148 7 has have VBZ cord-015306-us58wwmp 1148 8 been be VBN cord-015306-us58wwmp 1148 9 reported report VBN cord-015306-us58wwmp 1148 10 to to TO cord-015306-us58wwmp 1148 11 be be VB cord-015306-us58wwmp 1148 12 effective effective JJ cord-015306-us58wwmp 1148 13 for for IN cord-015306-us58wwmp 1148 14 improving improve VBG cord-015306-us58wwmp 1148 15 urinary urinary JJ cord-015306-us58wwmp 1148 16 abnormalities abnormality NNS cord-015306-us58wwmp 1148 17 and and CC cord-015306-us58wwmp 1148 18 preventing prevent VBG cord-015306-us58wwmp 1148 19 renal renal JJ cord-015306-us58wwmp 1148 20 deterioration deterioration NN cord-015306-us58wwmp 1148 21 in in IN cord-015306-us58wwmp 1148 22 patients patient NNS cord-015306-us58wwmp 1148 23 with with IN cord-015306-us58wwmp 1148 24 IgA IgA NNP cord-015306-us58wwmp 1148 25 nephropathy nephropathy NNP cord-015306-us58wwmp 1148 26 . . . cord-015306-us58wwmp 1149 1 However however RB cord-015306-us58wwmp 1149 2 , , , cord-015306-us58wwmp 1149 3 some some DT cord-015306-us58wwmp 1149 4 patients patient NNS cord-015306-us58wwmp 1149 5 are be VBP cord-015306-us58wwmp 1149 6 refractory refractory JJ cord-015306-us58wwmp 1149 7 to to IN cord-015306-us58wwmp 1149 8 SPT SPT NNP cord-015306-us58wwmp 1149 9 or or CC cord-015306-us58wwmp 1149 10 have have VBP cord-015306-us58wwmp 1149 11 relapse relapse NN cord-015306-us58wwmp 1149 12 after after IN cord-015306-us58wwmp 1149 13 SPT SPT NNP cord-015306-us58wwmp 1149 14 , , , cord-015306-us58wwmp 1149 15 resulting result VBG cord-015306-us58wwmp 1149 16 in in IN cord-015306-us58wwmp 1149 17 renal renal JJ cord-015306-us58wwmp 1149 18 impairment impairment NN cord-015306-us58wwmp 1149 19 . . . cord-015306-us58wwmp 1150 1 The the DT cord-015306-us58wwmp 1150 2 efficacy efficacy NN cord-015306-us58wwmp 1150 3 of of IN cord-015306-us58wwmp 1150 4 tonsillectomy tonsillectomy NN cord-015306-us58wwmp 1150 5 combined combine VBN cord-015306-us58wwmp 1150 6 with with IN cord-015306-us58wwmp 1150 7 SPT SPT NNP cord-015306-us58wwmp 1150 8 has have VBZ cord-015306-us58wwmp 1150 9 been be VBN cord-015306-us58wwmp 1150 10 discussed discuss VBN cord-015306-us58wwmp 1150 11 . . . cord-015306-us58wwmp 1151 1 The the DT cord-015306-us58wwmp 1151 2 aim aim NN cord-015306-us58wwmp 1151 3 of of IN cord-015306-us58wwmp 1151 4 our -PRON- PRP$ cord-015306-us58wwmp 1151 5 study study NN cord-015306-us58wwmp 1151 6 is be VBZ cord-015306-us58wwmp 1151 7 to to TO cord-015306-us58wwmp 1151 8 evaluate evaluate VB cord-015306-us58wwmp 1151 9 the the DT cord-015306-us58wwmp 1151 10 efficacy efficacy NN cord-015306-us58wwmp 1151 11 of of IN cord-015306-us58wwmp 1151 12 tonsillectomy tonsillectomy NN cord-015306-us58wwmp 1151 13 combined combine VBN cord-015306-us58wwmp 1151 14 with with IN cord-015306-us58wwmp 1151 15 SPT SPT NNP cord-015306-us58wwmp 1151 16 in in IN cord-015306-us58wwmp 1151 17 childhood childhood NN cord-015306-us58wwmp 1151 18 IgA IgA NNP cord-015306-us58wwmp 1151 19 nephropathy nephropathy NN cord-015306-us58wwmp 1151 20 . . . cord-015306-us58wwmp 1152 1 Methods method NNS cord-015306-us58wwmp 1152 2 : : : cord-015306-us58wwmp 1152 3 30 30 CD cord-015306-us58wwmp 1152 4 children child NNS cord-015306-us58wwmp 1152 5 , , , cord-015306-us58wwmp 1152 6 aged age VBN cord-015306-us58wwmp 1152 7 3 3 CD cord-015306-us58wwmp 1152 8 to to TO cord-015306-us58wwmp 1152 9 14 14 CD cord-015306-us58wwmp 1152 10 years year NNS cord-015306-us58wwmp 1152 11 , , , cord-015306-us58wwmp 1152 12 who who WP cord-015306-us58wwmp 1152 13 had have VBD cord-015306-us58wwmp 1152 14 been be VBN cord-015306-us58wwmp 1152 15 followed follow VBN cord-015306-us58wwmp 1152 16 up up RP cord-015306-us58wwmp 1152 17 for for IN cord-015306-us58wwmp 1152 18 more more JJR cord-015306-us58wwmp 1152 19 than than IN cord-015306-us58wwmp 1152 20 3 3 CD cord-015306-us58wwmp 1152 21 years year NNS cord-015306-us58wwmp 1152 22 after after IN cord-015306-us58wwmp 1152 23 the the DT cord-015306-us58wwmp 1152 24 first first JJ cord-015306-us58wwmp 1152 25 biopsy biopsy NN cord-015306-us58wwmp 1152 26 between between IN cord-015306-us58wwmp 1152 27 2001 2001 CD cord-015306-us58wwmp 1152 28 and and CC cord-015306-us58wwmp 1152 29 2009 2009 CD cord-015306-us58wwmp 1152 30 , , , cord-015306-us58wwmp 1152 31 were be VBD cord-015306-us58wwmp 1152 32 enrolled enrol VBN cord-015306-us58wwmp 1152 33 in in IN cord-015306-us58wwmp 1152 34 this this DT cord-015306-us58wwmp 1152 35 study study NN cord-015306-us58wwmp 1152 36 . . . cord-015306-us58wwmp 1153 1 All all DT cord-015306-us58wwmp 1153 2 patients patient NNS cord-015306-us58wwmp 1153 3 received receive VBD cord-015306-us58wwmp 1153 4 SPT SPT NNP cord-015306-us58wwmp 1153 5 ( ( -LRB- cord-015306-us58wwmp 1153 6 methylprednisolone methylprednisolone NN cord-015306-us58wwmp 1153 7 , , , cord-015306-us58wwmp 1153 8 20~30 20~30 CD cord-015306-us58wwmp 1153 9 mg mg NNP cord-015306-us58wwmp 1153 10 / / SYM cord-015306-us58wwmp 1153 11 kg kg CC cord-015306-us58wwmp 1153 12 intravenously intravenously RB cord-015306-us58wwmp 1153 13 3 3 CD cord-015306-us58wwmp 1153 14 times time NNS cord-015306-us58wwmp 1153 15 per per IN cord-015306-us58wwmp 1153 16 week week NN cord-015306-us58wwmp 1153 17 for for IN cord-015306-us58wwmp 1153 18 consecutive consecutive JJ cord-015306-us58wwmp 1153 19 3 3 CD cord-015306-us58wwmp 1153 20 weeks week NNS cord-015306-us58wwmp 1153 21 ) ) -RRB- cord-015306-us58wwmp 1153 22 . . . cord-015306-us58wwmp 1154 1 8 8 CD cord-015306-us58wwmp 1154 2 patients patient NNS cord-015306-us58wwmp 1154 3 received receive VBD cord-015306-us58wwmp 1154 4 tonsillectomy tonsillectomy NN cord-015306-us58wwmp 1154 5 combined combine VBN cord-015306-us58wwmp 1154 6 with with IN cord-015306-us58wwmp 1154 7 SPT SPT NNP cord-015306-us58wwmp 1154 8 ( ( -LRB- cord-015306-us58wwmp 1154 9 group group NN cord-015306-us58wwmp 1154 10 A A NNP cord-015306-us58wwmp 1154 11 ) ) -RRB- cord-015306-us58wwmp 1154 12 , , , cord-015306-us58wwmp 1154 13 and and CC cord-015306-us58wwmp 1154 14 22 22 CD cord-015306-us58wwmp 1154 15 patients patient NNS cord-015306-us58wwmp 1154 16 received receive VBD cord-015306-us58wwmp 1154 17 SPT SPT NNP cord-015306-us58wwmp 1154 18 alone alone JJ cord-015306-us58wwmp 1154 19 ( ( -LRB- cord-015306-us58wwmp 1154 20 group group NN cord-015306-us58wwmp 1154 21 B B NNP cord-015306-us58wwmp 1154 22 ) ) -RRB- cord-015306-us58wwmp 1154 23 . . . cord-015306-us58wwmp 1155 1 Tonsillectomy tonsillectomy NN cord-015306-us58wwmp 1155 2 was be VBD cord-015306-us58wwmp 1155 3 performed perform VBN cord-015306-us58wwmp 1155 4 one one CD cord-015306-us58wwmp 1155 5 month month NN cord-015306-us58wwmp 1155 6 before before IN cord-015306-us58wwmp 1155 7 or or CC cord-015306-us58wwmp 1155 8 after after IN cord-015306-us58wwmp 1155 9 SPT SPT NNP cord-015306-us58wwmp 1155 10 . . . cord-015306-us58wwmp 1156 1 The the DT cord-015306-us58wwmp 1156 2 therapy therapy NN cord-015306-us58wwmp 1156 3 was be VBD cord-015306-us58wwmp 1156 4 followed follow VBN cord-015306-us58wwmp 1156 5 by by IN cord-015306-us58wwmp 1156 6 oral oral JJ cord-015306-us58wwmp 1156 7 prednisolone prednisolone NN cord-015306-us58wwmp 1156 8 and and CC cord-015306-us58wwmp 1156 9 tapered taper VBD cord-015306-us58wwmp 1156 10 off off RP cord-015306-us58wwmp 1156 11 for for IN cord-015306-us58wwmp 1156 12 12 12 CD cord-015306-us58wwmp 1156 13 to to TO cord-015306-us58wwmp 1156 14 24 24 CD cord-015306-us58wwmp 1156 15 months month NNS cord-015306-us58wwmp 1156 16 , , , cord-015306-us58wwmp 1156 17 with with IN cord-015306-us58wwmp 1156 18 warfarin warfarin NN cord-015306-us58wwmp 1156 19 , , , cord-015306-us58wwmp 1156 20 dipyridamole dipyridamole NNP cord-015306-us58wwmp 1156 21 and and CC cord-015306-us58wwmp 1156 22 RAS RAS NNP cord-015306-us58wwmp 1156 23 inhibitor inhibitor NN cord-015306-us58wwmp 1156 24 . . . cord-015306-us58wwmp 1157 1 All all DT cord-015306-us58wwmp 1157 2 of of IN cord-015306-us58wwmp 1157 3 30 30 CD cord-015306-us58wwmp 1157 4 patients patient NNS cord-015306-us58wwmp 1157 5 underwent undergo VBD cord-015306-us58wwmp 1157 6 repeat repeat NN cord-015306-us58wwmp 1157 7 biopsy biopsy NN cord-015306-us58wwmp 1157 8 . . . cord-015306-us58wwmp 1158 1 Clinical clinical JJ cord-015306-us58wwmp 1158 2 features feature NNS cord-015306-us58wwmp 1158 3 and and CC cord-015306-us58wwmp 1158 4 pathological pathological JJ cord-015306-us58wwmp 1158 5 findings finding NNS cord-015306-us58wwmp 1158 6 were be VBD cord-015306-us58wwmp 1158 7 retrospectively retrospectively RB cord-015306-us58wwmp 1158 8 analyzed analyze VBN cord-015306-us58wwmp 1158 9 . . . cord-015306-us58wwmp 1159 1 Results result NNS cord-015306-us58wwmp 1159 2 : : : cord-015306-us58wwmp 1160 1 The the DT cord-015306-us58wwmp 1160 2 disappearance disappearance NN cord-015306-us58wwmp 1160 3 rate rate NN cord-015306-us58wwmp 1160 4 of of IN cord-015306-us58wwmp 1160 5 proteinuria proteinuria NN cord-015306-us58wwmp 1160 6 was be VBD cord-015306-us58wwmp 1160 7 87.5 87.5 CD cord-015306-us58wwmp 1160 8 % % NN cord-015306-us58wwmp 1160 9 for for IN cord-015306-us58wwmp 1160 10 group group NN cord-015306-us58wwmp 1160 11 A A NNP cord-015306-us58wwmp 1160 12 vs vs IN cord-015306-us58wwmp 1160 13 100 100 CD cord-015306-us58wwmp 1160 14 % % NN cord-015306-us58wwmp 1160 15 for for IN cord-015306-us58wwmp 1160 16 group group NN cord-015306-us58wwmp 1160 17 B b NN cord-015306-us58wwmp 1160 18 at at IN cord-015306-us58wwmp 1160 19 1 1 CD cord-015306-us58wwmp 1160 20 year year NN cord-015306-us58wwmp 1160 21 , , , cord-015306-us58wwmp 1160 22 and and CC cord-015306-us58wwmp 1160 23 that that DT cord-015306-us58wwmp 1160 24 of of IN cord-015306-us58wwmp 1160 25 hematuria hematuria NN cord-015306-us58wwmp 1160 26 was be VBD cord-015306-us58wwmp 1160 27 100 100 CD cord-015306-us58wwmp 1160 28 % % NN cord-015306-us58wwmp 1160 29 vs vs IN cord-015306-us58wwmp 1160 30 72.7 72.7 CD cord-015306-us58wwmp 1160 31 % % NN cord-015306-us58wwmp 1160 32 at at IN cord-015306-us58wwmp 1160 33 2 2 CD cord-015306-us58wwmp 1160 34 years year NNS cord-015306-us58wwmp 1160 35 . . . cord-015306-us58wwmp 1161 1 For for IN cord-015306-us58wwmp 1161 2 group group NN cord-015306-us58wwmp 1161 3 A A NNP cord-015306-us58wwmp 1161 4 , , , cord-015306-us58wwmp 1161 5 all all PDT cord-015306-us58wwmp 1161 6 the the DT cord-015306-us58wwmp 1161 7 cases case NNS cord-015306-us58wwmp 1161 8 which which WDT cord-015306-us58wwmp 1161 9 of of IN cord-015306-us58wwmp 1161 10 urinary urinary JJ cord-015306-us58wwmp 1161 11 abnormalities abnormality NNS cord-015306-us58wwmp 1161 12 had have VBD cord-015306-us58wwmp 1161 13 improved improve VBN cord-015306-us58wwmp 1161 14 by by IN cord-015306-us58wwmp 1161 15 the the DT cord-015306-us58wwmp 1161 16 treatment treatment NN cord-015306-us58wwmp 1161 17 could could MD cord-015306-us58wwmp 1161 18 maintain maintain VB cord-015306-us58wwmp 1161 19 remission remission NN cord-015306-us58wwmp 1161 20 , , , cord-015306-us58wwmp 1161 21 but but CC cord-015306-us58wwmp 1161 22 for for IN cord-015306-us58wwmp 1161 23 group group NN cord-015306-us58wwmp 1161 24 B b NN cord-015306-us58wwmp 1161 25 , , , cord-015306-us58wwmp 1161 26 27.3 27.3 CD cord-015306-us58wwmp 1161 27 % % NN cord-015306-us58wwmp 1161 28 of of IN cord-015306-us58wwmp 1161 29 the the DT cord-015306-us58wwmp 1161 30 cases case NNS cord-015306-us58wwmp 1161 31 had have VBD cord-015306-us58wwmp 1161 32 recurrence recurrence NN cord-015306-us58wwmp 1161 33 of of IN cord-015306-us58wwmp 1161 34 proteinuria proteinuria NN cord-015306-us58wwmp 1161 35 and and CC cord-015306-us58wwmp 1161 36 18.2 18.2 CD cord-015306-us58wwmp 1161 37 % % NN cord-015306-us58wwmp 1161 38 had have VBD cord-015306-us58wwmp 1161 39 recurrence recurrence NN cord-015306-us58wwmp 1161 40 or or CC cord-015306-us58wwmp 1161 41 did do VBD cord-015306-us58wwmp 1161 42 not not RB cord-015306-us58wwmp 1161 43 achieve achieve VB cord-015306-us58wwmp 1161 44 disappearance disappearance NN cord-015306-us58wwmp 1161 45 of of IN cord-015306-us58wwmp 1161 46 hematuria hematuria NN cord-015306-us58wwmp 1161 47 at at IN cord-015306-us58wwmp 1161 48 the the DT cord-015306-us58wwmp 1161 49 last last JJ cord-015306-us58wwmp 1161 50 observation observation NN cord-015306-us58wwmp 1161 51 . . . cord-015306-us58wwmp 1162 1 Histlogically histlogically RB cord-015306-us58wwmp 1162 2 , , , cord-015306-us58wwmp 1162 3 the the DT cord-015306-us58wwmp 1162 4 percentage percentage NN cord-015306-us58wwmp 1162 5 of of IN cord-015306-us58wwmp 1162 6 glomeruli glomerulus NNS cord-015306-us58wwmp 1162 7 that that WDT cord-015306-us58wwmp 1162 8 showed show VBD cord-015306-us58wwmp 1162 9 crescents crescent NNS cord-015306-us58wwmp 1162 10 was be VBD cord-015306-us58wwmp 1162 11 significantly significantly RB cord-015306-us58wwmp 1162 12 reduced reduce VBN cord-015306-us58wwmp 1162 13 in in IN cord-015306-us58wwmp 1162 14 both both DT cord-015306-us58wwmp 1162 15 groups group NNS cord-015306-us58wwmp 1162 16 . . . cord-015306-us58wwmp 1163 1 But but CC cord-015306-us58wwmp 1163 2 the the DT cord-015306-us58wwmp 1163 3 cases case NNS cord-015306-us58wwmp 1163 4 which which WDT cord-015306-us58wwmp 1163 5 still still RB cord-015306-us58wwmp 1163 6 showed show VBD cord-015306-us58wwmp 1163 7 crescent crescent JJ cord-015306-us58wwmp 1163 8 formation formation NN cord-015306-us58wwmp 1163 9 at at IN cord-015306-us58wwmp 1163 10 the the DT cord-015306-us58wwmp 1163 11 second second JJ cord-015306-us58wwmp 1163 12 biopsy biopsy NN cord-015306-us58wwmp 1163 13 were be VBD cord-015306-us58wwmp 1163 14 0 0 CD cord-015306-us58wwmp 1163 15 % % NN cord-015306-us58wwmp 1163 16 for for IN cord-015306-us58wwmp 1163 17 group group NN cord-015306-us58wwmp 1163 18 A A NNP cord-015306-us58wwmp 1163 19 vs vs IN cord-015306-us58wwmp 1163 20 22.7 22.7 CD cord-015306-us58wwmp 1163 21 % % NN cord-015306-us58wwmp 1163 22 for for IN cord-015306-us58wwmp 1163 23 group group NN cord-015306-us58wwmp 1163 24 B. B. NNP cord-015306-us58wwmp 1163 25 Conclusion Conclusion NNP cord-015306-us58wwmp 1163 26 : : : cord-015306-us58wwmp 1163 27 The the DT cord-015306-us58wwmp 1163 28 differences difference NNS cord-015306-us58wwmp 1163 29 of of IN cord-015306-us58wwmp 1163 30 recurrence recurrence NN cord-015306-us58wwmp 1163 31 rate rate NN cord-015306-us58wwmp 1163 32 for for IN cord-015306-us58wwmp 1163 33 urinary urinary JJ cord-015306-us58wwmp 1163 34 abnormalities abnormality NNS cord-015306-us58wwmp 1163 35 after after IN cord-015306-us58wwmp 1163 36 the the DT cord-015306-us58wwmp 1163 37 treatment treatment NN cord-015306-us58wwmp 1163 38 and and CC cord-015306-us58wwmp 1163 39 disappearance disappearance NN cord-015306-us58wwmp 1163 40 rate rate NN cord-015306-us58wwmp 1163 41 of of IN cord-015306-us58wwmp 1163 42 crescents crescent NNS cord-015306-us58wwmp 1163 43 at at IN cord-015306-us58wwmp 1163 44 second second JJ cord-015306-us58wwmp 1163 45 biopsy biopsy NN cord-015306-us58wwmp 1163 46 may may MD cord-015306-us58wwmp 1163 47 suggest suggest VB cord-015306-us58wwmp 1163 48 that that IN cord-015306-us58wwmp 1163 49 tonsillectomy tonsillectomy NN cord-015306-us58wwmp 1163 50 can can MD cord-015306-us58wwmp 1163 51 improve improve VB cord-015306-us58wwmp 1163 52 the the DT cord-015306-us58wwmp 1163 53 long long JJ cord-015306-us58wwmp 1163 54 - - HYPH cord-015306-us58wwmp 1163 55 term term NN cord-015306-us58wwmp 1163 56 prognosis prognosis NN cord-015306-us58wwmp 1163 57 . . . cord-015306-us58wwmp 1164 1 Objective objective NN cord-015306-us58wwmp 1164 2 : : : cord-015306-us58wwmp 1165 1 To to TO cord-015306-us58wwmp 1165 2 observe observe VB cord-015306-us58wwmp 1165 3 the the DT cord-015306-us58wwmp 1165 4 efficacy efficacy NN cord-015306-us58wwmp 1165 5 and and CC cord-015306-us58wwmp 1165 6 security security NN cord-015306-us58wwmp 1165 7 of of IN cord-015306-us58wwmp 1165 8 tripterygium tripterygium NNP cord-015306-us58wwmp 1165 9 wilfordii wilfordii NNP cord-015306-us58wwmp 1165 10 polyglycosidium polyglycosidium NNP cord-015306-us58wwmp 1165 11 ( ( -LRB- cord-015306-us58wwmp 1165 12 TWP TWP NNP cord-015306-us58wwmp 1165 13 ) ) -RRB- cord-015306-us58wwmp 1165 14 in in IN cord-015306-us58wwmp 1165 15 treating treat VBG cord-015306-us58wwmp 1165 16 children child NNS cord-015306-us58wwmp 1165 17 with with IN cord-015306-us58wwmp 1165 18 severe severe JJ cord-015306-us58wwmp 1165 19 Henoch Henoch NNP cord-015306-us58wwmp 1165 20 - - HYPH cord-015306-us58wwmp 1165 21 schonlein schonlein NNP cord-015306-us58wwmp 1165 22 Purpura Purpura NNP cord-015306-us58wwmp 1165 23 nephritis nephritis NN cord-015306-us58wwmp 1165 24 ( ( -LRB- cord-015306-us58wwmp 1165 25 HSPN HSPN NNP cord-015306-us58wwmp 1165 26 ) ) -RRB- cord-015306-us58wwmp 1165 27 . . . cord-015306-us58wwmp 1166 1 Methods method NNS cord-015306-us58wwmp 1166 2 : : : cord-015306-us58wwmp 1166 3 25 25 CD cord-015306-us58wwmp 1166 4 children child NNS cord-015306-us58wwmp 1166 5 failed fail VBD cord-015306-us58wwmp 1166 6 to to IN cord-015306-us58wwmp 1166 7 intravenous intravenous JJ cord-015306-us58wwmp 1166 8 pulse pulse NN cord-015306-us58wwmp 1166 9 methylprednisolone methylprednisolone NN cord-015306-us58wwmp 1166 10 for for IN cord-015306-us58wwmp 1166 11 6 6 CD cord-015306-us58wwmp 1166 12 days day NNS cord-015306-us58wwmp 1166 13 for for IN cord-015306-us58wwmp 1166 14 their -PRON- PRP$ cord-015306-us58wwmp 1166 15 severe severe JJ cord-015306-us58wwmp 1166 16 HSPN HSPN NNP cord-015306-us58wwmp 1166 17 entered enter VBD cord-015306-us58wwmp 1166 18 our -PRON- PRP$ cord-015306-us58wwmp 1166 19 study study NN cord-015306-us58wwmp 1166 20 and and CC cord-015306-us58wwmp 1166 21 were be VBD cord-015306-us58wwmp 1166 22 given give VBN cord-015306-us58wwmp 1166 23 oral oral JJ cord-015306-us58wwmp 1166 24 TWP TWP NNP cord-015306-us58wwmp 1166 25 for for IN cord-015306-us58wwmp 1166 26 3 3 CD cord-015306-us58wwmp 1166 27 - - SYM cord-015306-us58wwmp 1166 28 6 6 CD cord-015306-us58wwmp 1166 29 month month NN cord-015306-us58wwmp 1166 30 . . . cord-015306-us58wwmp 1167 1 We -PRON- PRP cord-015306-us58wwmp 1167 2 evaluated evaluate VBD cord-015306-us58wwmp 1167 3 the the DT cord-015306-us58wwmp 1167 4 efficacy efficacy NN cord-015306-us58wwmp 1167 5 and and CC cord-015306-us58wwmp 1167 6 security security NN cord-015306-us58wwmp 1167 7 of of IN cord-015306-us58wwmp 1167 8 TWP TWP NNP cord-015306-us58wwmp 1167 9 through through IN cord-015306-us58wwmp 1167 10 examinations examination NNS cord-015306-us58wwmp 1167 11 of of IN cord-015306-us58wwmp 1167 12 urinalysis urinalysis NN cord-015306-us58wwmp 1167 13 , , , cord-015306-us58wwmp 1167 14 blood blood NN cord-015306-us58wwmp 1167 15 routine routine NN cord-015306-us58wwmp 1167 16 , , , cord-015306-us58wwmp 1167 17 function function NN cord-015306-us58wwmp 1167 18 of of IN cord-015306-us58wwmp 1167 19 liver liver NN cord-015306-us58wwmp 1167 20 and and CC cord-015306-us58wwmp 1167 21 renal renal JJ cord-015306-us58wwmp 1167 22 , , , cord-015306-us58wwmp 1167 23 myocardial myocardial JJ cord-015306-us58wwmp 1167 24 enzyme enzyme NN cord-015306-us58wwmp 1167 25 series series NN cord-015306-us58wwmp 1167 26 , , , cord-015306-us58wwmp 1167 27 level level NN cord-015306-us58wwmp 1167 28 of of IN cord-015306-us58wwmp 1167 29 sex sex NN cord-015306-us58wwmp 1167 30 hormone hormone NN cord-015306-us58wwmp 1167 31 and and CC cord-015306-us58wwmp 1167 32 electrocardiogram electrocardiogram NN cord-015306-us58wwmp 1167 33 ( ( -LRB- cord-015306-us58wwmp 1167 34 ECG ECG NNP cord-015306-us58wwmp 1167 35 ) ) -RRB- cord-015306-us58wwmp 1167 36 before before IN cord-015306-us58wwmp 1167 37 treatment treatment NN cord-015306-us58wwmp 1167 38 , , , cord-015306-us58wwmp 1167 39 1 1 CD cord-015306-us58wwmp 1167 40 - - SYM cord-015306-us58wwmp 1167 41 2 2 CD cord-015306-us58wwmp 1167 42 month month NN cord-015306-us58wwmp 1167 43 after after IN cord-015306-us58wwmp 1167 44 giving give VBG cord-015306-us58wwmp 1167 45 TWF TWF NNP cord-015306-us58wwmp 1167 46 and and CC cord-015306-us58wwmp 1167 47 4 4 CD cord-015306-us58wwmp 1167 48 weeks week NNS cord-015306-us58wwmp 1167 49 after after IN cord-015306-us58wwmp 1167 50 stopping stop VBG cord-015306-us58wwmp 1167 51 medication medication NN cord-015306-us58wwmp 1167 52 respectively respectively RB cord-015306-us58wwmp 1167 53 . . . cord-015306-us58wwmp 1168 1 Results result NNS cord-015306-us58wwmp 1168 2 : : : cord-015306-us58wwmp 1169 1 Proteinuria Proteinuria NNP cord-015306-us58wwmp 1169 2 disappeared disappear VBD cord-015306-us58wwmp 1169 3 in in IN cord-015306-us58wwmp 1169 4 all all DT cord-015306-us58wwmp 1169 5 patients patient NNS cord-015306-us58wwmp 1169 6 . . . cord-015306-us58wwmp 1170 1 The the DT cord-015306-us58wwmp 1170 2 remission remission NN cord-015306-us58wwmp 1170 3 time time NN cord-015306-us58wwmp 1170 4 was be VBD cord-015306-us58wwmp 1170 5 4 4 CD cord-015306-us58wwmp 1170 6 weeks week NNS cord-015306-us58wwmp 1170 7 in in IN cord-015306-us58wwmp 1170 8 22 22 CD cord-015306-us58wwmp 1170 9 children child NNS cord-015306-us58wwmp 1170 10 , , , cord-015306-us58wwmp 1170 11 12 12 CD cord-015306-us58wwmp 1170 12 weeks week NNS cord-015306-us58wwmp 1170 13 in in IN cord-015306-us58wwmp 1170 14 2 2 CD cord-015306-us58wwmp 1170 15 , , , cord-015306-us58wwmp 1170 16 15 15 CD cord-015306-us58wwmp 1170 17 weeks week NNS cord-015306-us58wwmp 1170 18 in in IN cord-015306-us58wwmp 1170 19 1 1 CD cord-015306-us58wwmp 1170 20 respectively respectively RB cord-015306-us58wwmp 1170 21 . . . cord-015306-us58wwmp 1171 1 During during IN cord-015306-us58wwmp 1171 2 treatment treatment NN cord-015306-us58wwmp 1171 3 , , , cord-015306-us58wwmp 1171 4 elevated elevated JJ cord-015306-us58wwmp 1171 5 glutamic glutamic NN cord-015306-us58wwmp 1171 6 - - HYPH cord-015306-us58wwmp 1171 7 pyruvic pyruvic NN cord-015306-us58wwmp 1171 8 transaminase transaminase NN cord-015306-us58wwmp 1171 9 and and CC cord-015306-us58wwmp 1171 10 Glutamic Glutamic NNP cord-015306-us58wwmp 1171 11 - - HYPH cord-015306-us58wwmp 1171 12 Oxaloacetic Oxaloacetic NNP cord-015306-us58wwmp 1171 13 occurred occur VBD cord-015306-us58wwmp 1171 14 in in IN cord-015306-us58wwmp 1171 15 2 2 CD cord-015306-us58wwmp 1171 16 patients patient NNS cord-015306-us58wwmp 1171 17 and and CC cord-015306-us58wwmp 1171 18 returned return VBD cord-015306-us58wwmp 1171 19 to to IN cord-015306-us58wwmp 1171 20 normal normal JJ cord-015306-us58wwmp 1171 21 after after IN cord-015306-us58wwmp 1171 22 stopping stop VBG cord-015306-us58wwmp 1171 23 medication medication NN cord-015306-us58wwmp 1171 24 . . . cord-015306-us58wwmp 1172 1 Abnormal abnormal JJ cord-015306-us58wwmp 1172 2 findings finding NNS cord-015306-us58wwmp 1172 3 in in IN cord-015306-us58wwmp 1172 4 examination examination NN cord-015306-us58wwmp 1172 5 of of IN cord-015306-us58wwmp 1172 6 ECG ECG NNP cord-015306-us58wwmp 1172 7 were be VBD cord-015306-us58wwmp 1172 8 observed observe VBN cord-015306-us58wwmp 1172 9 in in IN cord-015306-us58wwmp 1172 10 2 2 CD cord-015306-us58wwmp 1172 11 patients patient NNS cord-015306-us58wwmp 1172 12 , , , cord-015306-us58wwmp 1172 13 one one CD cord-015306-us58wwmp 1172 14 with with IN cord-015306-us58wwmp 1172 15 left left JJ cord-015306-us58wwmp 1172 16 ventricular ventricular JJ cord-015306-us58wwmp 1172 17 high high JJ cord-015306-us58wwmp 1172 18 voltage voltage NN cord-015306-us58wwmp 1172 19 , , , cord-015306-us58wwmp 1172 20 another another DT cord-015306-us58wwmp 1172 21 with with IN cord-015306-us58wwmp 1172 22 knot knot NN cord-015306-us58wwmp 1172 23 parallel parallel JJ cord-015306-us58wwmp 1172 24 rhythm rhythm NN cord-015306-us58wwmp 1172 25 of of IN cord-015306-us58wwmp 1172 26 the the DT cord-015306-us58wwmp 1172 27 heart heart NN cord-015306-us58wwmp 1172 28 . . . cord-015306-us58wwmp 1173 1 After after IN cord-015306-us58wwmp 1173 2 stopping stop VBG cord-015306-us58wwmp 1173 3 medication medication NN cord-015306-us58wwmp 1173 4 , , , cord-015306-us58wwmp 1173 5 one one CD cord-015306-us58wwmp 1173 6 patient patient NN cord-015306-us58wwmp 1173 7 still still RB cord-015306-us58wwmp 1173 8 had have VBD cord-015306-us58wwmp 1173 9 T T NNP cord-015306-us58wwmp 1173 10 wave wave NN cord-015306-us58wwmp 1173 11 change change NN cord-015306-us58wwmp 1173 12 in in IN cord-015306-us58wwmp 1173 13 ECG ECG NNP cord-015306-us58wwmp 1173 14 . . . cord-015306-us58wwmp 1174 1 We -PRON- PRP cord-015306-us58wwmp 1174 2 did do VBD cord-015306-us58wwmp 1174 3 n't not RB cord-015306-us58wwmp 1174 4 find find VB cord-015306-us58wwmp 1174 5 any any DT cord-015306-us58wwmp 1174 6 abnormalities abnormality NNS cord-015306-us58wwmp 1174 7 of of IN cord-015306-us58wwmp 1174 8 blood blood NN cord-015306-us58wwmp 1174 9 routine routine JJ cord-015306-us58wwmp 1174 10 , , , cord-015306-us58wwmp 1174 11 renal renal JJ cord-015306-us58wwmp 1174 12 function function NN cord-015306-us58wwmp 1174 13 and and CC cord-015306-us58wwmp 1174 14 level level NN cord-015306-us58wwmp 1174 15 of of IN cord-015306-us58wwmp 1174 16 sex sex NN cord-015306-us58wwmp 1174 17 hormone hormone NN cord-015306-us58wwmp 1174 18 . . . cord-015306-us58wwmp 1175 1 Conclusion conclusion NN cord-015306-us58wwmp 1175 2 : : : cord-015306-us58wwmp 1176 1 The the DT cord-015306-us58wwmp 1176 2 TWP TWP NNP cord-015306-us58wwmp 1176 3 has have VBZ cord-015306-us58wwmp 1176 4 good good JJ cord-015306-us58wwmp 1176 5 efficacy efficacy NN cord-015306-us58wwmp 1176 6 and and CC cord-015306-us58wwmp 1176 7 security security NN cord-015306-us58wwmp 1176 8 on on IN cord-015306-us58wwmp 1176 9 the the DT cord-015306-us58wwmp 1176 10 treating treat VBG cord-015306-us58wwmp 1176 11 children child NNS cord-015306-us58wwmp 1176 12 with with IN cord-015306-us58wwmp 1176 13 severe severe JJ cord-015306-us58wwmp 1176 14 HSPN HSPN NNP cord-015306-us58wwmp 1176 15 . . . cord-015306-us58wwmp 1177 1 The the DT cord-015306-us58wwmp 1177 2 efficacy efficacy NN cord-015306-us58wwmp 1177 3 and and CC cord-015306-us58wwmp 1177 4 side side NN cord-015306-us58wwmp 1177 5 effects effect NNS cord-015306-us58wwmp 1177 6 of of IN cord-015306-us58wwmp 1177 7 glucocorticoids glucocorticoid NNS cord-015306-us58wwmp 1177 8 in in IN cord-015306-us58wwmp 1177 9 treating treat VBG cord-015306-us58wwmp 1177 10 children child NNS cord-015306-us58wwmp 1177 11 with with IN cord-015306-us58wwmp 1177 12 Henoch Henoch NNP cord-015306-us58wwmp 1177 13 - - HYPH cord-015306-us58wwmp 1177 14 Schonlein Schonlein NNP cord-015306-us58wwmp 1177 15 purpura purpura NN cord-015306-us58wwmp 1177 16 Kai Kai NNP cord-015306-us58wwmp 1177 17 - - HYPH cord-015306-us58wwmp 1177 18 yun yun NNP cord-015306-us58wwmp 1177 19 Liu Liu NNP cord-015306-us58wwmp 1177 20 , , , cord-015306-us58wwmp 1177 21 Ling Ling NNP cord-015306-us58wwmp 1177 22 Lu Lu NNP cord-015306-us58wwmp 1177 23 Pediatrics Pediatrics NNP cord-015306-us58wwmp 1177 24 , , , cord-015306-us58wwmp 1177 25 irst irst NNP cord-015306-us58wwmp 1177 26 Affiliated Affiliated NNP cord-015306-us58wwmp 1177 27 Hospital Hospital NNP cord-015306-us58wwmp 1177 28 of of IN cord-015306-us58wwmp 1177 29 Anhui Anhui NNP cord-015306-us58wwmp 1177 30 Medical Medical NNP cord-015306-us58wwmp 1177 31 University University NNP cord-015306-us58wwmp 1177 32 , , , cord-015306-us58wwmp 1177 33 Anhui Anhui NNP cord-015306-us58wwmp 1177 34 , , , cord-015306-us58wwmp 1178 1 China China NNP cord-015306-us58wwmp 1178 2 Objective Objective NNP cord-015306-us58wwmp 1178 3 : : : cord-015306-us58wwmp 1178 4 To to TO cord-015306-us58wwmp 1178 5 observe observe VB cord-015306-us58wwmp 1178 6 the the DT cord-015306-us58wwmp 1178 7 efficacy efficacy NN cord-015306-us58wwmp 1178 8 and and CC cord-015306-us58wwmp 1178 9 safety safety NN cord-015306-us58wwmp 1178 10 of of IN cord-015306-us58wwmp 1178 11 glucocorticoid glucocorticoid NN cord-015306-us58wwmp 1178 12 in in IN cord-015306-us58wwmp 1178 13 the the DT cord-015306-us58wwmp 1178 14 treatment treatment NN cord-015306-us58wwmp 1178 15 of of IN cord-015306-us58wwmp 1178 16 children child NNS cord-015306-us58wwmp 1178 17 with with IN cord-015306-us58wwmp 1178 18 Henoch Henoch NNP cord-015306-us58wwmp 1178 19 - - HYPH cord-015306-us58wwmp 1178 20 Schonlein Schonlein NNP cord-015306-us58wwmp 1178 21 purpura purpura NN cord-015306-us58wwmp 1178 22 . . . cord-015306-us58wwmp 1179 1 Methods method NNS cord-015306-us58wwmp 1179 2 : : : cord-015306-us58wwmp 1179 3 50 50 CD cord-015306-us58wwmp 1179 4 patients patient NNS cord-015306-us58wwmp 1179 5 with with IN cord-015306-us58wwmp 1179 6 HSP HSP NNP cord-015306-us58wwmp 1179 7 were be VBD cord-015306-us58wwmp 1179 8 divided divide VBN cord-015306-us58wwmp 1179 9 into into IN cord-015306-us58wwmp 1179 10 mild mild JJ cord-015306-us58wwmp 1179 11 and and CC cord-015306-us58wwmp 1179 12 severe severe JJ cord-015306-us58wwmp 1179 13 group group NN cord-015306-us58wwmp 1179 14 according accord VBG cord-015306-us58wwmp 1179 15 to to IN cord-015306-us58wwmp 1179 16 clinical clinical JJ cord-015306-us58wwmp 1179 17 manifestations manifestation NNS cord-015306-us58wwmp 1179 18 . . . cord-015306-us58wwmp 1180 1 30 30 CD cord-015306-us58wwmp 1180 2 children child NNS cord-015306-us58wwmp 1180 3 in in IN cord-015306-us58wwmp 1180 4 mild mild JJ cord-015306-us58wwmp 1180 5 group group NN cord-015306-us58wwmp 1180 6 were be VBD cord-015306-us58wwmp 1180 7 given give VBN cord-015306-us58wwmp 1180 8 hydrocortisone hydrocortisone NN cord-015306-us58wwmp 1180 9 sodium sodium NN cord-015306-us58wwmp 1180 10 succinate succinate NNP cord-015306-us58wwmp 1180 11 ( ( -LRB- cord-015306-us58wwmp 1180 12 HCSS HCSS NNP cord-015306-us58wwmp 1180 13 ) ) -RRB- cord-015306-us58wwmp 1180 14 therapy therapy NN cord-015306-us58wwmp 1180 15 . . . cord-015306-us58wwmp 1181 1 20 20 CD cord-015306-us58wwmp 1181 2 children child NNS cord-015306-us58wwmp 1181 3 in in IN cord-015306-us58wwmp 1181 4 severe severe JJ cord-015306-us58wwmp 1181 5 group group NN cord-015306-us58wwmp 1181 6 were be VBD cord-015306-us58wwmp 1181 7 given give VBN cord-015306-us58wwmp 1181 8 methylprednisolone methylprednisolone NN cord-015306-us58wwmp 1181 9 ( ( -LRB- cord-015306-us58wwmp 1181 10 MP MP NNP cord-015306-us58wwmp 1181 11 ) ) -RRB- cord-015306-us58wwmp 1181 12 therapy therapy NN cord-015306-us58wwmp 1181 13 . . . cord-015306-us58wwmp 1182 1 A a DT cord-015306-us58wwmp 1182 2 follow follow VB cord-015306-us58wwmp 1182 3 - - HYPH cord-015306-us58wwmp 1182 4 up up RP cord-015306-us58wwmp 1182 5 record record NN cord-015306-us58wwmp 1182 6 system system NN cord-015306-us58wwmp 1182 7 was be VBD cord-015306-us58wwmp 1182 8 set set VBN cord-015306-us58wwmp 1182 9 up up RP cord-015306-us58wwmp 1182 10 for for IN cord-015306-us58wwmp 1182 11 every every DT cord-015306-us58wwmp 1182 12 patient patient NN cord-015306-us58wwmp 1182 13 . . . cord-015306-us58wwmp 1183 1 We -PRON- PRP cord-015306-us58wwmp 1183 2 observed observe VBD cord-015306-us58wwmp 1183 3 the the DT cord-015306-us58wwmp 1183 4 recovery recovery NN cord-015306-us58wwmp 1183 5 time time NN cord-015306-us58wwmp 1183 6 of of IN cord-015306-us58wwmp 1183 7 clinical clinical JJ cord-015306-us58wwmp 1183 8 symptoms symptom NNS cord-015306-us58wwmp 1183 9 and and CC cord-015306-us58wwmp 1183 10 side side NN cord-015306-us58wwmp 1183 11 effects effect NNS cord-015306-us58wwmp 1183 12 of of IN cord-015306-us58wwmp 1183 13 glucocorticoid glucocorticoid NN cord-015306-us58wwmp 1183 14 . . . cord-015306-us58wwmp 1184 1 Results result NNS cord-015306-us58wwmp 1184 2 : : : cord-015306-us58wwmp 1185 1 Symptoms symptom NNS cord-015306-us58wwmp 1185 2 of of IN cord-015306-us58wwmp 1185 3 skin skin NN cord-015306-us58wwmp 1185 4 rashes rash NNS cord-015306-us58wwmp 1185 5 , , , cord-015306-us58wwmp 1185 6 joint joint JJ cord-015306-us58wwmp 1185 7 and and CC cord-015306-us58wwmp 1185 8 gastrointestinal gastrointestinal JJ cord-015306-us58wwmp 1185 9 in in IN cord-015306-us58wwmp 1185 10 all all DT cord-015306-us58wwmp 1185 11 children child NNS cord-015306-us58wwmp 1185 12 were be VBD cord-015306-us58wwmp 1185 13 disappeared disappear VBN cord-015306-us58wwmp 1185 14 within within IN cord-015306-us58wwmp 1185 15 3 3 CD cord-015306-us58wwmp 1185 16 months month NNS cord-015306-us58wwmp 1185 17 of of IN cord-015306-us58wwmp 1185 18 treatment treatment NN cord-015306-us58wwmp 1185 19 . . . cord-015306-us58wwmp 1186 1 The the DT cord-015306-us58wwmp 1186 2 urinalysis urinalysis NN cord-015306-us58wwmp 1186 3 in in IN cord-015306-us58wwmp 1186 4 13 13 CD cord-015306-us58wwmp 1186 5 of of IN cord-015306-us58wwmp 1186 6 14 14 CD cord-015306-us58wwmp 1186 7 patients patient NNS cord-015306-us58wwmp 1186 8 with with IN cord-015306-us58wwmp 1186 9 renal renal JJ cord-015306-us58wwmp 1186 10 involvement involvement NN cord-015306-us58wwmp 1186 11 returned return VBD cord-015306-us58wwmp 1186 12 to to IN cord-015306-us58wwmp 1186 13 normal normal JJ cord-015306-us58wwmp 1186 14 in in IN cord-015306-us58wwmp 1186 15 4 4 CD cord-015306-us58wwmp 1186 16 weeks week NNS cord-015306-us58wwmp 1186 17 . . . cord-015306-us58wwmp 1187 1 The the DT cord-015306-us58wwmp 1187 2 other other JJ cord-015306-us58wwmp 1187 3 patient patient NN cord-015306-us58wwmp 1187 4 failed fail VBD cord-015306-us58wwmp 1187 5 to to IN cord-015306-us58wwmp 1187 6 MP MP NNP cord-015306-us58wwmp 1187 7 therapy therapy NN cord-015306-us58wwmp 1187 8 was be VBD cord-015306-us58wwmp 1187 9 given give VBN cord-015306-us58wwmp 1187 10 oral oral JJ cord-015306-us58wwmp 1187 11 Tripterygium Tripterygium NNP cord-015306-us58wwmp 1187 12 and and CC cord-015306-us58wwmp 1187 13 got get VBD cord-015306-us58wwmp 1187 14 normal normal JJ cord-015306-us58wwmp 1187 15 urinalysis urinalysis NN cord-015306-us58wwmp 1187 16 in in IN cord-015306-us58wwmp 1187 17 8 8 CD cord-015306-us58wwmp 1187 18 weeks week NNS cord-015306-us58wwmp 1187 19 after after IN cord-015306-us58wwmp 1187 20 disease disease NN cord-015306-us58wwmp 1187 21 onset onset NN cord-015306-us58wwmp 1187 22 . . . cord-015306-us58wwmp 1188 1 The the DT cord-015306-us58wwmp 1188 2 Body Body NNP cord-015306-us58wwmp 1188 3 Mass Mass NNP cord-015306-us58wwmp 1188 4 Index Index NNP cord-015306-us58wwmp 1188 5 ( ( -LRB- cord-015306-us58wwmp 1188 6 BMI BMI NNP cord-015306-us58wwmp 1188 7 ) ) -RRB- cord-015306-us58wwmp 1188 8 values value NNS cord-015306-us58wwmp 1188 9 in in IN cord-015306-us58wwmp 1188 10 all all DT cord-015306-us58wwmp 1188 11 children child NNS cord-015306-us58wwmp 1188 12 after after IN cord-015306-us58wwmp 1188 13 glucocorticoid glucocorticoid NN cord-015306-us58wwmp 1188 14 treatment treatment NN cord-015306-us58wwmp 1188 15 were be VBD cord-015306-us58wwmp 1188 16 significantly significantly RB cord-015306-us58wwmp 1188 17 higher high JJR cord-015306-us58wwmp 1188 18 than than IN cord-015306-us58wwmp 1188 19 before before IN cord-015306-us58wwmp 1188 20 treatment treatment NN cord-015306-us58wwmp 1188 21 . . . cord-015306-us58wwmp 1189 1 After after IN cord-015306-us58wwmp 1189 2 stopping stop VBG cord-015306-us58wwmp 1189 3 medication medication NN cord-015306-us58wwmp 1189 4 , , , cord-015306-us58wwmp 1189 5 there there EX cord-015306-us58wwmp 1189 6 was be VBD cord-015306-us58wwmp 1189 7 no no DT cord-015306-us58wwmp 1189 8 significant significant JJ cord-015306-us58wwmp 1189 9 difference difference NN cord-015306-us58wwmp 1189 10 in in IN cord-015306-us58wwmp 1189 11 BMI BMI NNP cord-015306-us58wwmp 1189 12 value value NN cord-015306-us58wwmp 1189 13 compared compare VBN cord-015306-us58wwmp 1189 14 with with IN cord-015306-us58wwmp 1189 15 before before IN cord-015306-us58wwmp 1189 16 treatment treatment NN cord-015306-us58wwmp 1189 17 and and CC cord-015306-us58wwmp 1189 18 between between IN cord-015306-us58wwmp 1189 19 two two CD cord-015306-us58wwmp 1189 20 groups group NNS cord-015306-us58wwmp 1189 21 . . . cord-015306-us58wwmp 1190 1 During during IN cord-015306-us58wwmp 1190 2 the the DT cord-015306-us58wwmp 1190 3 treatment treatment NN cord-015306-us58wwmp 1190 4 , , , cord-015306-us58wwmp 1190 5 1 1 CD cord-015306-us58wwmp 1190 6 patient patient NN cord-015306-us58wwmp 1190 7 in in IN cord-015306-us58wwmp 1190 8 each each DT cord-015306-us58wwmp 1190 9 group group NN cord-015306-us58wwmp 1190 10 had have VBD cord-015306-us58wwmp 1190 11 ECG ECG NNP cord-015306-us58wwmp 1190 12 abnormal abnormal JJ cord-015306-us58wwmp 1190 13 , , , cord-015306-us58wwmp 1190 14 and and CC cord-015306-us58wwmp 1190 15 their -PRON- PRP$ cord-015306-us58wwmp 1190 16 ECG ECG NNP cord-015306-us58wwmp 1190 17 returned return VBD cord-015306-us58wwmp 1190 18 to to IN cord-015306-us58wwmp 1190 19 normal normal JJ cord-015306-us58wwmp 1190 20 after after IN cord-015306-us58wwmp 1190 21 stopping stop VBG cord-015306-us58wwmp 1190 22 drug drug NN cord-015306-us58wwmp 1190 23 . . . cord-015306-us58wwmp 1191 1 We -PRON- PRP cord-015306-us58wwmp 1191 2 did do VBD cord-015306-us58wwmp 1191 3 n't not RB cord-015306-us58wwmp 1191 4 find find VB cord-015306-us58wwmp 1191 5 any any DT cord-015306-us58wwmp 1191 6 abnormalities abnormality NNS cord-015306-us58wwmp 1191 7 of of IN cord-015306-us58wwmp 1191 8 blood blood NN cord-015306-us58wwmp 1191 9 routine routine JJ cord-015306-us58wwmp 1191 10 , , , cord-015306-us58wwmp 1191 11 renal renal JJ cord-015306-us58wwmp 1191 12 function function NN cord-015306-us58wwmp 1191 13 and and CC cord-015306-us58wwmp 1191 14 level level NN cord-015306-us58wwmp 1191 15 of of IN cord-015306-us58wwmp 1191 16 sex sex NN cord-015306-us58wwmp 1191 17 hormone hormone NN cord-015306-us58wwmp 1191 18 . . . cord-015306-us58wwmp 1192 1 Objective objective NN cord-015306-us58wwmp 1192 2 : : : cord-015306-us58wwmp 1193 1 To to TO cord-015306-us58wwmp 1193 2 investigate investigate VB cord-015306-us58wwmp 1193 3 the the DT cord-015306-us58wwmp 1193 4 role role NN cord-015306-us58wwmp 1193 5 of of IN cord-015306-us58wwmp 1193 6 Th17/ Th17/ NNS cord-015306-us58wwmp 1194 1 Treg Treg NNP cord-015306-us58wwmp 1194 2 imbalance imbalance NN cord-015306-us58wwmp 1194 3 in in IN cord-015306-us58wwmp 1194 4 the the DT cord-015306-us58wwmp 1194 5 pathogenesis pathogenesis NN cord-015306-us58wwmp 1194 6 of of IN cord-015306-us58wwmp 1194 7 childhood childhood NN cord-015306-us58wwmp 1194 8 Henoch Henoch NNP cord-015306-us58wwmp 1194 9 - - HYPH cord-015306-us58wwmp 1194 10 Schonlein Schonlein NNP cord-015306-us58wwmp 1194 11 purpura(HSP purpura(HSP NNP cord-015306-us58wwmp 1194 12 ) ) -RRB- cord-015306-us58wwmp 1194 13 . . . cord-015306-us58wwmp 1195 1 And and CC cord-015306-us58wwmp 1195 2 further far RBR cord-015306-us58wwmp 1195 3 explore explore VB cord-015306-us58wwmp 1195 4 the the DT cord-015306-us58wwmp 1195 5 immunomodulatory immunomodulatory JJ cord-015306-us58wwmp 1195 6 affects affect NNS cord-015306-us58wwmp 1195 7 of of IN cord-015306-us58wwmp 1195 8 compound compound NN cord-015306-us58wwmp 1195 9 / / SYM cord-015306-us58wwmp 1195 10 lycyrrhizin(GL lycyrrhizin(gl NN cord-015306-us58wwmp 1195 11 ) ) -RRB- cord-015306-us58wwmp 1196 1 on on IN cord-015306-us58wwmp 1196 2 the the DT cord-015306-us58wwmp 1196 3 Th17 Th17 NNP cord-015306-us58wwmp 1196 4 / / SYM cord-015306-us58wwmp 1196 5 Treg Treg NNP cord-015306-us58wwmp 1196 6 deviation deviation NN cord-015306-us58wwmp 1196 7 in in IN cord-015306-us58wwmp 1196 8 HSP HSP NNP cord-015306-us58wwmp 1196 9 . . . cord-015306-us58wwmp 1197 1 Methods method NNS cord-015306-us58wwmp 1197 2 : : : cord-015306-us58wwmp 1197 3 31 31 CD cord-015306-us58wwmp 1197 4 HSP HSP NNP cord-015306-us58wwmp 1197 5 patients patient NNS cord-015306-us58wwmp 1197 6 were be VBD cord-015306-us58wwmp 1197 7 chose choose VBN cord-015306-us58wwmp 1197 8 as as IN cord-015306-us58wwmp 1197 9 GL GL NNP cord-015306-us58wwmp 1197 10 - - HYPH cord-015306-us58wwmp 1197 11 treated treat VBN cord-015306-us58wwmp 1197 12 group group NN cord-015306-us58wwmp 1197 13 , , , cord-015306-us58wwmp 1197 14 another another DT cord-015306-us58wwmp 1197 15 5 5 CD cord-015306-us58wwmp 1197 16 patients patient NNS cord-015306-us58wwmp 1197 17 were be VBD cord-015306-us58wwmp 1197 18 used use VBN cord-015306-us58wwmp 1197 19 as as IN cord-015306-us58wwmp 1197 20 conventional conventional JJ cord-015306-us58wwmp 1197 21 therapy therapy NN cord-015306-us58wwmp 1197 22 group group NN cord-015306-us58wwmp 1197 23 . . . cord-015306-us58wwmp 1198 1 Besides besides IN cord-015306-us58wwmp 1198 2 ( ( -LRB- cord-015306-us58wwmp 1198 3 0.5 0.5 CD cord-015306-us58wwmp 1198 4 - - HYPH cord-015306-us58wwmp 1198 5 2)ml 2)ml CD cord-015306-us58wwmp 1198 6 / / SYM cord-015306-us58wwmp 1198 7 kg kg NN cord-015306-us58wwmp 1198 8 / / SYM cord-015306-us58wwmp 1198 9 L L NNP cord-015306-us58wwmp 1198 10 was be VBD cord-015306-us58wwmp 1198 11 enjected enjecte VBN cord-015306-us58wwmp 1198 12 in in IN cord-015306-us58wwmp 1198 13 L l NN cord-015306-us58wwmp 1198 14 - - HYPH cord-015306-us58wwmp 1198 15 treated treat VBN cord-015306-us58wwmp 1198 16 group group NN cord-015306-us58wwmp 1198 17 , , , cord-015306-us58wwmp 1198 18 other other JJ cord-015306-us58wwmp 1198 19 treatments treatment NNS cord-015306-us58wwmp 1198 20 were be VBD cord-015306-us58wwmp 1198 21 same same JJ cord-015306-us58wwmp 1198 22 , , , cord-015306-us58wwmp 1198 23 any any DT cord-015306-us58wwmp 1198 24 steroid steroid NN cord-015306-us58wwmp 1198 25 or or CC cord-015306-us58wwmp 1198 26 immunosuppressants immunosuppressant NNS cord-015306-us58wwmp 1198 27 treatment treatment NN cord-015306-us58wwmp 1198 28 was be VBD cord-015306-us58wwmp 1198 29 prohibited prohibit VBN cord-015306-us58wwmp 1198 30 . . . cord-015306-us58wwmp 1199 1 15 15 CD cord-015306-us58wwmp 1199 2 age age NN cord-015306-us58wwmp 1199 3 and and CC cord-015306-us58wwmp 1199 4 sex sex NN cord-015306-us58wwmp 1199 5 - - HYPH cord-015306-us58wwmp 1199 6 matched match VBN cord-015306-us58wwmp 1199 7 healthy healthy JJ cord-015306-us58wwmp 1199 8 children child NNS cord-015306-us58wwmp 1199 9 were be VBD cord-015306-us58wwmp 1199 10 used use VBN cord-015306-us58wwmp 1199 11 as as IN cord-015306-us58wwmp 1199 12 healthy healthy JJ cord-015306-us58wwmp 1199 13 controls control NNS cord-015306-us58wwmp 1199 14 . . . cord-015306-us58wwmp 1200 1 Blood blood NN cord-015306-us58wwmp 1200 2 samples sample NNS cord-015306-us58wwmp 1200 3 of of IN cord-015306-us58wwmp 1200 4 patients patient NNS cord-015306-us58wwmp 1200 5 were be VBD cord-015306-us58wwmp 1200 6 obtained obtain VBN cord-015306-us58wwmp 1200 7 at at IN cord-015306-us58wwmp 1200 8 the the DT cord-015306-us58wwmp 1200 9 acute acute JJ cord-015306-us58wwmp 1200 10 stage stage NN cord-015306-us58wwmp 1200 11 and and CC cord-015306-us58wwmp 1200 12 after after IN cord-015306-us58wwmp 1200 13 5 5 CD cord-015306-us58wwmp 1200 14 days day NNS cord-015306-us58wwmp 1200 15 treatment treatment NN cord-015306-us58wwmp 1200 16 . . . cord-015306-us58wwmp 1201 1 Using use VBG cord-015306-us58wwmp 1201 2 intracellular intracellular JJ cord-015306-us58wwmp 1201 3 staining staining NN cord-015306-us58wwmp 1201 4 , , , cord-015306-us58wwmp 1201 5 the the DT cord-015306-us58wwmp 1201 6 frequency frequency NN cord-015306-us58wwmp 1201 7 of of IN cord-015306-us58wwmp 1201 8 peripheral peripheral JJ cord-015306-us58wwmp 1201 9 CD3+CD8-IL17+(Th17 CD3+CD8-IL17+(Th17 NNP cord-015306-us58wwmp 1201 10 ) ) -RRB- cord-015306-us58wwmp 1201 11 and and CC cord-015306-us58wwmp 1202 1 CD4+CD25+FOXP3 CD4+CD25+FOXP3 NNP cord-015306-us58wwmp 1202 2 + + CC cord-015306-us58wwmp 1202 3 Treg Treg NNP cord-015306-us58wwmp 1202 4 cells cell NNS cord-015306-us58wwmp 1202 5 was be VBD cord-015306-us58wwmp 1202 6 detected detect VBN cord-015306-us58wwmp 1202 7 by by IN cord-015306-us58wwmp 1202 8 flow flow NN cord-015306-us58wwmp 1202 9 cytometry cytometry NN cord-015306-us58wwmp 1203 1 All all DT cord-015306-us58wwmp 1203 2 patients patient NNS cord-015306-us58wwmp 1203 3 received receive VBD cord-015306-us58wwmp 1203 4 methyl methyl NN cord-015306-us58wwmp 1203 5 - - HYPH cord-015306-us58wwmp 1203 6 prednisone prednisone NNP cord-015306-us58wwmp 1203 7 pulses pulse NNS cord-015306-us58wwmp 1203 8 iv iv LS cord-015306-us58wwmp 1203 9 ( ( -LRB- cord-015306-us58wwmp 1203 10 1 1 CD cord-015306-us58wwmp 1203 11 g/1.73 g/1.73 NN cord-015306-us58wwmp 1203 12 m2 m2 NNP cord-015306-us58wwmp 1203 13 for for IN cord-015306-us58wwmp 1203 14 3 3 CD cord-015306-us58wwmp 1203 15 consecutives consecutive NNS cord-015306-us58wwmp 1203 16 days day NNS cord-015306-us58wwmp 1203 17 ) ) -RRB- cord-015306-us58wwmp 1203 18 and and CC cord-015306-us58wwmp 1203 19 subsequently subsequently RB cord-015306-us58wwmp 1203 20 oral oral JJ cord-015306-us58wwmp 1203 21 Prednisone Prednisone NNP cord-015306-us58wwmp 1203 22 with with IN cord-015306-us58wwmp 1203 23 gradual gradual JJ cord-015306-us58wwmp 1203 24 withdrawal withdrawal NN cord-015306-us58wwmp 1203 25 in in IN cord-015306-us58wwmp 1203 26 six six CD cord-015306-us58wwmp 1203 27 months month NNS cord-015306-us58wwmp 1203 28 , , , cord-015306-us58wwmp 1203 29 and and CC cord-015306-us58wwmp 1203 30 MMF mmf NN cord-015306-us58wwmp 1203 31 at at IN cord-015306-us58wwmp 1203 32 dose dose NN cord-015306-us58wwmp 1203 33 of of IN cord-015306-us58wwmp 1203 34 10 10 CD cord-015306-us58wwmp 1203 35 - - SYM cord-015306-us58wwmp 1203 36 20 20 CD cord-015306-us58wwmp 1203 37 mg mg NNP cord-015306-us58wwmp 1203 38 / / , cord-015306-us58wwmp 1203 39 kg/12 kg/12 NNP cord-015306-us58wwmp 1203 40 h h NNP cord-015306-us58wwmp 1203 41 for for IN cord-015306-us58wwmp 1203 42 24 24 CD cord-015306-us58wwmp 1203 43 months month NNS cord-015306-us58wwmp 1203 44 . . . cord-015306-us58wwmp 1204 1 Results result NNS cord-015306-us58wwmp 1204 2 : : : cord-015306-us58wwmp 1205 1 After after IN cord-015306-us58wwmp 1205 2 six six CD cord-015306-us58wwmp 1205 3 months month NNS cord-015306-us58wwmp 1205 4 of of IN cord-015306-us58wwmp 1205 5 therapy therapy NN cord-015306-us58wwmp 1205 6 all all DT cord-015306-us58wwmp 1205 7 patients patient NNS cord-015306-us58wwmp 1205 8 but but CC cord-015306-us58wwmp 1205 9 one one PRP cord-015306-us58wwmp 1205 10 had have VBD cord-015306-us58wwmp 1205 11 persistent persistent JJ cord-015306-us58wwmp 1205 12 microscopic microscopic JJ cord-015306-us58wwmp 1205 13 hematuria hematuria NN cord-015306-us58wwmp 1205 14 ( ( -LRB- cord-015306-us58wwmp 1205 15 ME ME NNP cord-015306-us58wwmp 1205 16 ) ) -RRB- cord-015306-us58wwmp 1205 17 , , , cord-015306-us58wwmp 1205 18 only only RB cord-015306-us58wwmp 1205 19 3/11 3/11 CD cord-015306-us58wwmp 1205 20 patients patient NNS cord-015306-us58wwmp 1205 21 had have VBD cord-015306-us58wwmp 1205 22 recurrent recurrent JJ cord-015306-us58wwmp 1205 23 MA MA NNP cord-015306-us58wwmp 1205 24 . . . cord-015306-us58wwmp 1206 1 Patients patient NNS cord-015306-us58wwmp 1206 2 with with IN cord-015306-us58wwmp 1206 3 grade grade NN cord-015306-us58wwmp 1206 4 II ii CD cord-015306-us58wwmp 1206 5 HSPN HSPN NNP cord-015306-us58wwmp 1206 6 showed show VBD cord-015306-us58wwmp 1206 7 significant significant JJ cord-015306-us58wwmp 1206 8 reduction reduction NN cord-015306-us58wwmp 1206 9 or or CC cord-015306-us58wwmp 1206 10 normal normal JJ cord-015306-us58wwmp 1206 11 proteinuria proteinuria NN cord-015306-us58wwmp 1206 12 . . . cord-015306-us58wwmp 1207 1 Only only RB cord-015306-us58wwmp 1207 2 3/11 3/11 CD cord-015306-us58wwmp 1207 3 patients patient NNS cord-015306-us58wwmp 1207 4 with with IN cord-015306-us58wwmp 1207 5 grade grade NN cord-015306-us58wwmp 1207 6 III iii CD cord-015306-us58wwmp 1207 7 HSPN HSPN NNP cord-015306-us58wwmp 1207 8 had have VBD cord-015306-us58wwmp 1207 9 proteinuria proteinuria NN cord-015306-us58wwmp 1207 10 still still RB cord-015306-us58wwmp 1207 11 > > XX cord-015306-us58wwmp 1207 12 1gr/24 1gr/24 NNP cord-015306-us58wwmp 1207 13 h h NN cord-015306-us58wwmp 1207 14 , , , cord-015306-us58wwmp 1208 1 4/11 4/11 CD cord-015306-us58wwmp 1208 2 patients patient NNS cord-015306-us58wwmp 1208 3 had have VBD cord-015306-us58wwmp 1208 4 proteinuria proteinuria VBN cord-015306-us58wwmp 1209 1 < < NNP cord-015306-us58wwmp 1209 2 1g/24 1g/24 NNP cord-015306-us58wwmp 1209 3 h h NNP cord-015306-us58wwmp 1209 4 , , , cord-015306-us58wwmp 1209 5 in in IN cord-015306-us58wwmp 1209 6 4/11 4/11 CD cord-015306-us58wwmp 1209 7 proteinuria proteinuria NN cord-015306-us58wwmp 1209 8 was be VBD cord-015306-us58wwmp 1209 9 normal normal JJ cord-015306-us58wwmp 1209 10 . . . cord-015306-us58wwmp 1210 1 Mean mean JJ cord-015306-us58wwmp 1210 2 period period NN cord-015306-us58wwmp 1210 3 of of IN cord-015306-us58wwmp 1210 4 follow follow NN cord-015306-us58wwmp 1210 5 - - HYPH cord-015306-us58wwmp 1210 6 up up NN cord-015306-us58wwmp 1210 7 was be VBD cord-015306-us58wwmp 1210 8 3 3 CD cord-015306-us58wwmp 1210 9 years year NNS cord-015306-us58wwmp 1210 10 . . . cord-015306-us58wwmp 1211 1 After after IN cord-015306-us58wwmp 1211 2 one one CD cord-015306-us58wwmp 1211 3 year year NN cord-015306-us58wwmp 1211 4 , , , cord-015306-us58wwmp 1211 5 only only RB cord-015306-us58wwmp 1211 6 1 1 CD cord-015306-us58wwmp 1211 7 patient patient NN cord-015306-us58wwmp 1211 8 had have VBD cord-015306-us58wwmp 1211 9 recurrent recurrent JJ cord-015306-us58wwmp 1211 10 MA MA NNP cord-015306-us58wwmp 1211 11 , , , cord-015306-us58wwmp 1211 12 10 10 CD cord-015306-us58wwmp 1211 13 patients patient NNS cord-015306-us58wwmp 1211 14 showed show VBD cord-015306-us58wwmp 1211 15 persistent persistent JJ cord-015306-us58wwmp 1211 16 ME ME NNP cord-015306-us58wwmp 1211 17 . . . cord-015306-us58wwmp 1212 1 Two two CD cord-015306-us58wwmp 1212 2 patients patient NNS cord-015306-us58wwmp 1212 3 with with IN cord-015306-us58wwmp 1212 4 persistent persistent JJ cord-015306-us58wwmp 1212 5 proteinuria proteinuria NN cord-015306-us58wwmp 1212 6 > > XX cord-015306-us58wwmp 1212 7 1 1 CD cord-015306-us58wwmp 1212 8 g/24 g/24 NNP cord-015306-us58wwmp 1212 9 h h NNP cord-015306-us58wwmp 1212 10 showed show VBD cord-015306-us58wwmp 1212 11 a a DT cord-015306-us58wwmp 1212 12 significant significant JJ cord-015306-us58wwmp 1212 13 reduction reduction NN cord-015306-us58wwmp 1212 14 ( ( -LRB- cord-015306-us58wwmp 1212 15 < < NNP cord-015306-us58wwmp 1212 16 1g/24 1g/24 NNP cord-015306-us58wwmp 1212 17 h h NNP cord-015306-us58wwmp 1212 18 in in IN cord-015306-us58wwmp 1212 19 2 2 CD cord-015306-us58wwmp 1212 20 pts pt NNS cord-015306-us58wwmp 1212 21 , , , cord-015306-us58wwmp 1212 22 normal normal JJ cord-015306-us58wwmp 1212 23 in in IN cord-015306-us58wwmp 1212 24 1 1 CD cord-015306-us58wwmp 1212 25 pt pt NN cord-015306-us58wwmp 1212 26 ) ) -RRB- cord-015306-us58wwmp 1212 27 . . . cord-015306-us58wwmp 1213 1 Proteinuria Proteinuria NNP cord-015306-us58wwmp 1213 2 did do VBD cord-015306-us58wwmp 1213 3 not not RB cord-015306-us58wwmp 1213 4 reappear reappear VB cord-015306-us58wwmp 1213 5 in in IN cord-015306-us58wwmp 1213 6 all all DT cord-015306-us58wwmp 1213 7 patients patient NNS cord-015306-us58wwmp 1213 8 . . . cord-015306-us58wwmp 1214 1 The the DT cord-015306-us58wwmp 1214 2 effect effect NN cord-015306-us58wwmp 1214 3 persisted persist VBD cord-015306-us58wwmp 1214 4 after after IN cord-015306-us58wwmp 1214 5 2 2 CD cord-015306-us58wwmp 1214 6 years year NNS cord-015306-us58wwmp 1214 7 and and CC cord-015306-us58wwmp 1214 8 after after IN cord-015306-us58wwmp 1214 9 therapy therapy NN cord-015306-us58wwmp 1214 10 withdrawal withdrawal NN cord-015306-us58wwmp 1214 11 . . . cord-015306-us58wwmp 1215 1 No no DT cord-015306-us58wwmp 1215 2 side side NN cord-015306-us58wwmp 1215 3 effects effect NNS cord-015306-us58wwmp 1215 4 was be VBD cord-015306-us58wwmp 1215 5 recorded record VBN cord-015306-us58wwmp 1215 6 . . . cord-015306-us58wwmp 1216 1 Conclusion conclusion NN cord-015306-us58wwmp 1216 2 : : : cord-015306-us58wwmp 1217 1 our -PRON- PRP$ cord-015306-us58wwmp 1217 2 experience experience NN cord-015306-us58wwmp 1217 3 shows show VBZ cord-015306-us58wwmp 1217 4 the the DT cord-015306-us58wwmp 1217 5 efficacy efficacy NN cord-015306-us58wwmp 1217 6 and and CC cord-015306-us58wwmp 1217 7 safety safety NN cord-015306-us58wwmp 1217 8 of of IN cord-015306-us58wwmp 1217 9 MMF MMF NNP cord-015306-us58wwmp 1217 10 in in IN cord-015306-us58wwmp 1217 11 HSPN HSPN NNP cord-015306-us58wwmp 1217 12 and and CC cord-015306-us58wwmp 1217 13 has have VBZ cord-015306-us58wwmp 1217 14 to to TO cord-015306-us58wwmp 1217 15 be be VB cord-015306-us58wwmp 1217 16 confirmed confirm VBN cord-015306-us58wwmp 1217 17 by by IN cord-015306-us58wwmp 1217 18 larger large JJR cord-015306-us58wwmp 1217 19 controlled control VBN cord-015306-us58wwmp 1217 20 studies study NNS cord-015306-us58wwmp 1217 21 . . . cord-015306-us58wwmp 1218 1 The the DT cord-015306-us58wwmp 1218 2 Analysis Analysis NNP cord-015306-us58wwmp 1218 3 of of IN cord-015306-us58wwmp 1218 4 Blood Blood NNP cord-015306-us58wwmp 1218 5 Perfusion perfusion NN cord-015306-us58wwmp 1218 6 Therapeutic therapeutic JJ cord-015306-us58wwmp 1218 7 Effect effect NN cord-015306-us58wwmp 1218 8 on on IN cord-015306-us58wwmp 1218 9 45 45 CD cord-015306-us58wwmp 1218 10 Cases case NNS cord-015306-us58wwmp 1218 11 of of IN cord-015306-us58wwmp 1218 12 Allergic Allergic NNP cord-015306-us58wwmp 1218 13 Purpura Purpura NNP cord-015306-us58wwmp 1218 14 CHENG CHENG NNP cord-015306-us58wwmp 1218 15 Guo Guo NNP cord-015306-us58wwmp 1218 16 - - HYPH cord-015306-us58wwmp 1218 17 qiang qiang NNP cord-015306-us58wwmp 1218 18 Xi Xi NNP cord-015306-us58wwmp 1218 19 ' ' '' cord-015306-us58wwmp 1218 20 an an DT cord-015306-us58wwmp 1218 21 children child NNS cord-015306-us58wwmp 1218 22 's 's POS cord-015306-us58wwmp 1218 23 hospital hospital NN cord-015306-us58wwmp 1218 24 urology urology NNP cord-015306-us58wwmp 1218 25 department department NNP cord-015306-us58wwmp 1218 26 , , , cord-015306-us58wwmp 1218 27 Xi'an Xi'an NNP cord-015306-us58wwmp 1218 28 , , , cord-015306-us58wwmp 1218 29 Shanxi Shanxi NNP cord-015306-us58wwmp 1218 30 , , , cord-015306-us58wwmp 1218 31 China China NNP cord-015306-us58wwmp 1218 32 Objective Objective NNP cord-015306-us58wwmp 1218 33 : : : cord-015306-us58wwmp 1218 34 To to TO cord-015306-us58wwmp 1218 35 observe observe VB cord-015306-us58wwmp 1218 36 the the DT cord-015306-us58wwmp 1218 37 auxiliary auxiliary JJ cord-015306-us58wwmp 1218 38 therapeutic therapeutic JJ cord-015306-us58wwmp 1218 39 effect effect NN cord-015306-us58wwmp 1218 40 on on IN cord-015306-us58wwmp 1218 41 severe severe JJ cord-015306-us58wwmp 1218 42 allergic allergic JJ cord-015306-us58wwmp 1218 43 purpura purpura NN cord-015306-us58wwmp 1218 44 . . . cord-015306-us58wwmp 1219 1 Methods method NNS cord-015306-us58wwmp 1219 2 : : : cord-015306-us58wwmp 1219 3 45 45 CD cord-015306-us58wwmp 1219 4 children child NNS cord-015306-us58wwmp 1219 5 with with IN cord-015306-us58wwmp 1219 6 severe severe JJ cord-015306-us58wwmp 1219 7 allergic allergic JJ cord-015306-us58wwmp 1219 8 purpura purpura NN cord-015306-us58wwmp 1219 9 were be VBD cord-015306-us58wwmp 1219 10 randomly randomly RB cord-015306-us58wwmp 1219 11 divided divide VBN cord-015306-us58wwmp 1219 12 into into IN cord-015306-us58wwmp 1219 13 the the DT cord-015306-us58wwmp 1219 14 control control NN cord-015306-us58wwmp 1219 15 group group NN cord-015306-us58wwmp 1219 16 ( ( -LRB- cord-015306-us58wwmp 1219 17 19 19 CD cord-015306-us58wwmp 1219 18 cases case NNS cord-015306-us58wwmp 1219 19 ) ) -RRB- cord-015306-us58wwmp 1219 20 and and CC cord-015306-us58wwmp 1219 21 the the DT cord-015306-us58wwmp 1219 22 treatment treatment NN cord-015306-us58wwmp 1219 23 group group NN cord-015306-us58wwmp 1219 24 ( ( -LRB- cord-015306-us58wwmp 1219 25 26 26 CD cord-015306-us58wwmp 1219 26 cases case NNS cord-015306-us58wwmp 1219 27 ) ) -RRB- cord-015306-us58wwmp 1219 28 . . . cord-015306-us58wwmp 1220 1 The the DT cord-015306-us58wwmp 1220 2 children child NNS cord-015306-us58wwmp 1220 3 of of IN cord-015306-us58wwmp 1220 4 control control NN cord-015306-us58wwmp 1220 5 group group NN cord-015306-us58wwmp 1220 6 were be VBD cord-015306-us58wwmp 1220 7 treated treat VBN cord-015306-us58wwmp 1220 8 with with IN cord-015306-us58wwmp 1220 9 conventional conventional JJ cord-015306-us58wwmp 1220 10 therapy therapy NN cord-015306-us58wwmp 1220 11 ( ( -LRB- cord-015306-us58wwmp 1220 12 anti anti JJ cord-015306-us58wwmp 1220 13 - - JJ cord-015306-us58wwmp 1220 14 inflammatory inflammatory JJ cord-015306-us58wwmp 1220 15 , , , cord-015306-us58wwmp 1220 16 anti anti JJ cord-015306-us58wwmp 1220 17 - - JJ cord-015306-us58wwmp 1220 18 allergic allergic JJ cord-015306-us58wwmp 1220 19 , , , cord-015306-us58wwmp 1220 20 anticoagulation anticoagulation NN cord-015306-us58wwmp 1220 21 and and CC cord-015306-us58wwmp 1220 22 symptomatic symptomatic JJ cord-015306-us58wwmp 1220 23 treatment treatment NN cord-015306-us58wwmp 1220 24 ) ) -RRB- cord-015306-us58wwmp 1220 25 . . . cord-015306-us58wwmp 1221 1 The the DT cord-015306-us58wwmp 1221 2 children child NNS cord-015306-us58wwmp 1221 3 of of IN cord-015306-us58wwmp 1221 4 treatment treatment NN cord-015306-us58wwmp 1221 5 group group NN cord-015306-us58wwmp 1221 6 were be VBD cord-015306-us58wwmp 1221 7 treated treat VBN cord-015306-us58wwmp 1221 8 with with IN cord-015306-us58wwmp 1221 9 conventional conventional JJ cord-015306-us58wwmp 1221 10 therapy therapy NN cord-015306-us58wwmp 1221 11 and and CC cord-015306-us58wwmp 1221 12 blood blood NN cord-015306-us58wwmp 1221 13 perfusion perfusion NN cord-015306-us58wwmp 1221 14 . . . cord-015306-us58wwmp 1222 1 Two two CD cord-015306-us58wwmp 1222 2 groups group NNS cord-015306-us58wwmp 1222 3 of of IN cord-015306-us58wwmp 1222 4 patients patient NNS cord-015306-us58wwmp 1222 5 were be VBD cord-015306-us58wwmp 1222 6 both both DT cord-015306-us58wwmp 1222 7 treated treat VBN cord-015306-us58wwmp 1222 8 for for IN cord-015306-us58wwmp 1222 9 14 14 CD cord-015306-us58wwmp 1222 10 days day NNS cord-015306-us58wwmp 1222 11 , , , cord-015306-us58wwmp 1222 12 and and CC cord-015306-us58wwmp 1222 13 were be VBD cord-015306-us58wwmp 1222 14 followed follow VBN cord-015306-us58wwmp 1222 15 up up RP cord-015306-us58wwmp 1222 16 for for IN cord-015306-us58wwmp 1222 17 9 9 CD cord-015306-us58wwmp 1222 18 months month NNS cord-015306-us58wwmp 1222 19 . . . cord-015306-us58wwmp 1223 1 The the DT cord-015306-us58wwmp 1223 2 amelioration amelioration NN cord-015306-us58wwmp 1223 3 time time NN cord-015306-us58wwmp 1223 4 and and CC cord-015306-us58wwmp 1223 5 the the DT cord-015306-us58wwmp 1223 6 regression regression NN cord-015306-us58wwmp 1223 7 time time NN cord-015306-us58wwmp 1223 8 of of IN cord-015306-us58wwmp 1223 9 clinical clinical JJ cord-015306-us58wwmp 1223 10 symptoms symptom NNS cord-015306-us58wwmp 1223 11 such such JJ cord-015306-us58wwmp 1223 12 as as IN cord-015306-us58wwmp 1223 13 abdominal abdominal JJ cord-015306-us58wwmp 1223 14 pain pain NN cord-015306-us58wwmp 1223 15 , , , cord-015306-us58wwmp 1223 16 bloody bloody JJ cord-015306-us58wwmp 1223 17 stool stool NN cord-015306-us58wwmp 1223 18 , , , cord-015306-us58wwmp 1223 19 rash rash JJ cord-015306-us58wwmp 1223 20 , , , cord-015306-us58wwmp 1223 21 joint joint JJ cord-015306-us58wwmp 1223 22 symptoms symptom NNS cord-015306-us58wwmp 1223 23 , , , cord-015306-us58wwmp 1223 24 visible visible JJ cord-015306-us58wwmp 1223 25 hematuria hematuria NN cord-015306-us58wwmp 1223 26 and and CC cord-015306-us58wwmp 1223 27 proteinuria proteinuria NN cord-015306-us58wwmp 1223 28 , , , cord-015306-us58wwmp 1223 29 was be VBD cord-015306-us58wwmp 1223 30 compared compare VBN cord-015306-us58wwmp 1223 31 in in IN cord-015306-us58wwmp 1223 32 two two CD cord-015306-us58wwmp 1223 33 groups group NNS cord-015306-us58wwmp 1223 34 before before IN cord-015306-us58wwmp 1223 35 and and CC cord-015306-us58wwmp 1223 36 after after IN cord-015306-us58wwmp 1223 37 the the DT cord-015306-us58wwmp 1223 38 treatment treatment NN cord-015306-us58wwmp 1223 39 . . . cord-015306-us58wwmp 1224 1 The the DT cord-015306-us58wwmp 1224 2 amelioration amelioration NN cord-015306-us58wwmp 1224 3 time time NN cord-015306-us58wwmp 1224 4 of of IN cord-015306-us58wwmp 1224 5 the the DT cord-015306-us58wwmp 1224 6 clinical clinical JJ cord-015306-us58wwmp 1224 7 symptoms symptom NNS cord-015306-us58wwmp 1224 8 of of IN cord-015306-us58wwmp 1224 9 children child NNS cord-015306-us58wwmp 1224 10 in in IN cord-015306-us58wwmp 1224 11 the the DT cord-015306-us58wwmp 1224 12 treatment treatment NN cord-015306-us58wwmp 1224 13 group group NN cord-015306-us58wwmp 1224 14 , , , cord-015306-us58wwmp 1224 15 such such JJ cord-015306-us58wwmp 1224 16 as as IN cord-015306-us58wwmp 1224 17 acute acute JJ cord-015306-us58wwmp 1224 18 abdominal abdominal JJ cord-015306-us58wwmp 1224 19 pain pain NN cord-015306-us58wwmp 1224 20 , , , cord-015306-us58wwmp 1224 21 bloody bloody JJ cord-015306-us58wwmp 1224 22 stool stool NN cord-015306-us58wwmp 1224 23 , , , cord-015306-us58wwmp 1224 24 rash rash JJ cord-015306-us58wwmp 1224 25 , , , cord-015306-us58wwmp 1224 26 joint joint JJ cord-015306-us58wwmp 1224 27 symptoms symptom NNS cord-015306-us58wwmp 1224 28 , , , cord-015306-us58wwmp 1224 29 abdominal abdominal JJ cord-015306-us58wwmp 1224 30 pain pain NN cord-015306-us58wwmp 1224 31 and and CC cord-015306-us58wwmp 1224 32 bloody bloody JJ cord-015306-us58wwmp 1224 33 stool stool NN cord-015306-us58wwmp 1224 34 , , , cord-015306-us58wwmp 1224 35 visible visible JJ cord-015306-us58wwmp 1224 36 hematuria hematuria NN cord-015306-us58wwmp 1224 37 , , , cord-015306-us58wwmp 1224 38 proteinuria proteinuria NN cord-015306-us58wwmp 1224 39 , , , cord-015306-us58wwmp 1224 40 and and CC cord-015306-us58wwmp 1224 41 other other JJ cord-015306-us58wwmp 1224 42 clinical clinical JJ cord-015306-us58wwmp 1224 43 symptoms symptom NNS cord-015306-us58wwmp 1224 44 , , , cord-015306-us58wwmp 1224 45 was be VBD cord-015306-us58wwmp 1224 46 shorter short JJR cord-015306-us58wwmp 1224 47 than than IN cord-015306-us58wwmp 1224 48 the the DT cord-015306-us58wwmp 1224 49 time time NN cord-015306-us58wwmp 1224 50 in in IN cord-015306-us58wwmp 1224 51 the the DT cord-015306-us58wwmp 1224 52 control control NN cord-015306-us58wwmp 1224 53 group group NN cord-015306-us58wwmp 1224 54 ( ( -LRB- cord-015306-us58wwmp 1224 55 P p NN cord-015306-us58wwmp 1224 56 < < XX cord-015306-us58wwmp 1224 57 0.05 0.05 CD cord-015306-us58wwmp 1224 58 ) ) -RRB- cord-015306-us58wwmp 1224 59 , , , cord-015306-us58wwmp 1224 60 and and CC cord-015306-us58wwmp 1224 61 the the DT cord-015306-us58wwmp 1224 62 late late JJ cord-015306-us58wwmp 1224 63 symptoms symptom NNS cord-015306-us58wwmp 1224 64 such such JJ cord-015306-us58wwmp 1224 65 as as IN cord-015306-us58wwmp 1224 66 joint joint JJ cord-015306-us58wwmp 1224 67 symptoms symptom NNS cord-015306-us58wwmp 1224 68 , , , cord-015306-us58wwmp 1224 69 abdominal abdominal JJ cord-015306-us58wwmp 1224 70 pain pain NN cord-015306-us58wwmp 1224 71 and and CC cord-015306-us58wwmp 1224 72 bloody bloody JJ cord-015306-us58wwmp 1224 73 stool stool NN cord-015306-us58wwmp 1224 74 iterations iteration NNS cord-015306-us58wwmp 1224 75 was be VBD cord-015306-us58wwmp 1224 76 also also RB cord-015306-us58wwmp 1224 77 less less JJR cord-015306-us58wwmp 1224 78 than than IN cord-015306-us58wwmp 1224 79 those those DT cord-015306-us58wwmp 1224 80 of of IN cord-015306-us58wwmp 1224 81 the the DT cord-015306-us58wwmp 1224 82 control control NN cord-015306-us58wwmp 1224 83 group group NN cord-015306-us58wwmp 1224 84 ( ( -LRB- cord-015306-us58wwmp 1224 85 P p NN cord-015306-us58wwmp 1224 86 < < XX cord-015306-us58wwmp 1224 87 0.05 0.05 CD cord-015306-us58wwmp 1224 88 ) ) -RRB- cord-015306-us58wwmp 1224 89 . . . cord-015306-us58wwmp 1225 1 Methods method NNS cord-015306-us58wwmp 1225 2 : : : cord-015306-us58wwmp 1225 3 IgA IgA NNP cord-015306-us58wwmp 1225 4 nephropathy nephropathy NNP cord-015306-us58wwmp 1225 5 model model NN cord-015306-us58wwmp 1225 6 was be VBD cord-015306-us58wwmp 1225 7 established establish VBN cord-015306-us58wwmp 1225 8 in in IN cord-015306-us58wwmp 1225 9 male male JJ cord-015306-us58wwmp 1225 10 Sprague Sprague NNP cord-015306-us58wwmp 1225 11 - - HYPH cord-015306-us58wwmp 1225 12 Dawley Dawley NNP cord-015306-us58wwmp 1225 13 rats rat NNS cord-015306-us58wwmp 1225 14 . . . cord-015306-us58wwmp 1226 1 At at IN cord-015306-us58wwmp 1226 2 week week NN cord-015306-us58wwmp 1226 3 10 10 CD cord-015306-us58wwmp 1226 4 , , , cord-015306-us58wwmp 1226 5 rats rat NNS cord-015306-us58wwmp 1226 6 in in IN cord-015306-us58wwmp 1226 7 the the DT cord-015306-us58wwmp 1226 8 model model NN cord-015306-us58wwmp 1226 9 group group NN cord-015306-us58wwmp 1226 10 were be VBD cord-015306-us58wwmp 1226 11 randomly randomly RB cord-015306-us58wwmp 1226 12 assigned assign VBN cord-015306-us58wwmp 1226 13 to to IN cord-015306-us58wwmp 1226 14 either either DT cord-015306-us58wwmp 1226 15 remain remain VB cord-015306-us58wwmp 1226 16 in in IN cord-015306-us58wwmp 1226 17 the the DT cord-015306-us58wwmp 1226 18 model model NN cord-015306-us58wwmp 1226 19 group group NN cord-015306-us58wwmp 1226 20 ( ( -LRB- cord-015306-us58wwmp 1226 21 n=5 n=5 NNP cord-015306-us58wwmp 1226 22 ) ) -RRB- cord-015306-us58wwmp 1226 23 , , , cord-015306-us58wwmp 1226 24 or or CC cord-015306-us58wwmp 1226 25 to to TO cord-015306-us58wwmp 1226 26 receive receive VB cord-015306-us58wwmp 1226 27 treatment treatment NN cord-015306-us58wwmp 1226 28 with with IN cord-015306-us58wwmp 1226 29 rednisone rednisone NNP cord-015306-us58wwmp 1226 30 ( ( -LRB- cord-015306-us58wwmp 1226 31 n=6 n=6 NNP cord-015306-us58wwmp 1226 32 ) ) -RRB- cord-015306-us58wwmp 1226 33 , , , cord-015306-us58wwmp 1226 34 1,25(OH 1,25(oh CD cord-015306-us58wwmp 1226 35 ) ) -RRB- cord-015306-us58wwmp 1226 36 2 2 CD cord-015306-us58wwmp 1226 37 D d NN cord-015306-us58wwmp 1226 38 3 3 CD cord-015306-us58wwmp 1226 39 group group NN cord-015306-us58wwmp 1226 40 ( ( -LRB- cord-015306-us58wwmp 1226 41 n=6 n=6 NNP cord-015306-us58wwmp 1226 42 ) ) -RRB- cord-015306-us58wwmp 1226 43 , , , cord-015306-us58wwmp 1226 44 or or CC cord-015306-us58wwmp 1226 45 prednisone prednisone NN cord-015306-us58wwmp 1226 46 plus plus CC cord-015306-us58wwmp 1226 47 1,25(OH)2D3 1,25(oh)2d3 CD cord-015306-us58wwmp 1226 48 ( ( -LRB- cord-015306-us58wwmp 1226 49 n=6 n=6 NNP cord-015306-us58wwmp 1226 50 ) ) -RRB- cord-015306-us58wwmp 1226 51 . . . cord-015306-us58wwmp 1227 1 At at IN cord-015306-us58wwmp 1227 2 week week NN cord-015306-us58wwmp 1227 3 12 12 CD cord-015306-us58wwmp 1227 4 , , , cord-015306-us58wwmp 1227 5 serum serum NN cord-015306-us58wwmp 1227 6 interleukin-17 interleukin-17 NN cord-015306-us58wwmp 1227 7 level level NN cord-015306-us58wwmp 1227 8 was be VBD cord-015306-us58wwmp 1227 9 detected detect VBN cord-015306-us58wwmp 1227 10 by by IN cord-015306-us58wwmp 1227 11 ELISA ELISA NNP cord-015306-us58wwmp 1227 12 , , , cord-015306-us58wwmp 1227 13 and and CC cord-015306-us58wwmp 1227 14 the the DT cord-015306-us58wwmp 1227 15 level level NN cord-015306-us58wwmp 1227 16 of of IN cord-015306-us58wwmp 1227 17 Treg Treg NNP cord-015306-us58wwmp 1227 18 cells cell NNS cord-015306-us58wwmp 1227 19 in in IN cord-015306-us58wwmp 1227 20 the the DT cord-015306-us58wwmp 1227 21 blood blood NN cord-015306-us58wwmp 1227 22 was be VBD cord-015306-us58wwmp 1227 23 assayed assay VBN cord-015306-us58wwmp 1227 24 using use VBG cord-015306-us58wwmp 1227 25 a a DT cord-015306-us58wwmp 1227 26 flow flow NN cord-015306-us58wwmp 1227 27 cytometry cytometry NN cord-015306-us58wwmp 1227 28 method method NN cord-015306-us58wwmp 1227 29 . . . cord-015306-us58wwmp 1228 1 Results result NNS cord-015306-us58wwmp 1228 2 : : : cord-015306-us58wwmp 1228 3 ( ( -LRB- cord-015306-us58wwmp 1228 4 1 1 LS cord-015306-us58wwmp 1228 5 ) ) -RRB- cord-015306-us58wwmp 1229 1 The the DT cord-015306-us58wwmp 1229 2 proteinurine proteinurine NN cord-015306-us58wwmp 1229 3 and and CC cord-015306-us58wwmp 1229 4 the the DT cord-015306-us58wwmp 1229 5 number number NN cord-015306-us58wwmp 1229 6 of of IN cord-015306-us58wwmp 1229 7 blood blood NN cord-015306-us58wwmp 1229 8 cells cell NNS cord-015306-us58wwmp 1229 9 in in IN cord-015306-us58wwmp 1229 10 urine urine NN cord-015306-us58wwmp 1229 11 from from IN cord-015306-us58wwmp 1229 12 rats rat NNS cord-015306-us58wwmp 1229 13 in in IN cord-015306-us58wwmp 1229 14 the the DT cord-015306-us58wwmp 1229 15 model model NN cord-015306-us58wwmp 1229 16 group group NN cord-015306-us58wwmp 1229 17 was be VBD cord-015306-us58wwmp 1229 18 significantly significantly RB cord-015306-us58wwmp 1229 19 higher high JJR cord-015306-us58wwmp 1229 20 than than IN cord-015306-us58wwmp 1229 21 in in IN cord-015306-us58wwmp 1229 22 rats rat NNS cord-015306-us58wwmp 1229 23 in in IN cord-015306-us58wwmp 1229 24 the the DT cord-015306-us58wwmp 1229 25 control control NN cord-015306-us58wwmp 1229 26 , , , cord-015306-us58wwmp 1229 27 prednisone prednisone NNP cord-015306-us58wwmp 1229 28 , , , cord-015306-us58wwmp 1229 29 1,25(OH)2D3 1,25(oh)2d3 CD cord-015306-us58wwmp 1229 30 , , , cord-015306-us58wwmp 1229 31 and and CC cord-015306-us58wwmp 1229 32 prednisone prednisone NNP cord-015306-us58wwmp 1229 33 plus plus CC cord-015306-us58wwmp 1229 34 1,25(OH)2D3 1,25(oh)2d3 CD cord-015306-us58wwmp 1229 35 treatment treatment NN cord-015306-us58wwmp 1229 36 groups group NNS cord-015306-us58wwmp 1229 37 ( ( -LRB- cord-015306-us58wwmp 1229 38 P p NN cord-015306-us58wwmp 1229 39 < < XX cord-015306-us58wwmp 1229 40 0.01 0.01 CD cord-015306-us58wwmp 1229 41 ) ) -RRB- cord-015306-us58wwmp 1229 42 . . . cord-015306-us58wwmp 1230 1 ( ( -LRB- cord-015306-us58wwmp 1230 2 2 2 LS cord-015306-us58wwmp 1230 3 ) ) -RRB- cord-015306-us58wwmp 1230 4 Serum serum NN cord-015306-us58wwmp 1230 5 interleukin-17 interleukin-17 NN cord-015306-us58wwmp 1230 6 in in IN cord-015306-us58wwmp 1230 7 the the DT cord-015306-us58wwmp 1230 8 model model NN cord-015306-us58wwmp 1230 9 group group NN cord-015306-us58wwmp 1230 10 was be VBD cord-015306-us58wwmp 1230 11 significantly significantly RB cord-015306-us58wwmp 1230 12 increased increase VBN cord-015306-us58wwmp 1230 13 compared compare VBN cord-015306-us58wwmp 1230 14 with with IN cord-015306-us58wwmp 1230 15 control control NN cord-015306-us58wwmp 1230 16 and and CC cord-015306-us58wwmp 1230 17 treatment treatment NN cord-015306-us58wwmp 1230 18 groups group NNS cord-015306-us58wwmp 1230 19 ( ( -LRB- cord-015306-us58wwmp 1230 20 P p NN cord-015306-us58wwmp 1230 21 < < XX cord-015306-us58wwmp 1230 22 0.01 0.01 CD cord-015306-us58wwmp 1230 23 ) ) -RRB- cord-015306-us58wwmp 1230 24 , , , cord-015306-us58wwmp 1230 25 and and CC cord-015306-us58wwmp 1230 26 the the DT cord-015306-us58wwmp 1230 27 levels level NNS cord-015306-us58wwmp 1230 28 were be VBD cord-015306-us58wwmp 1230 29 decreased decrease VBN cord-015306-us58wwmp 1230 30 in in IN cord-015306-us58wwmp 1230 31 turn turn NN cord-015306-us58wwmp 1230 32 in in IN cord-015306-us58wwmp 1230 33 the the DT cord-015306-us58wwmp 1230 34 prednisone prednisone NNP cord-015306-us58wwmp 1230 35 treatment treatment NNP cord-015306-us58wwmp 1230 36 group group NNP cord-015306-us58wwmp 1230 37 , , , cord-015306-us58wwmp 1230 38 1,25(OH)2D3 1,25(oh)2d3 CD cord-015306-us58wwmp 1230 39 treatment treatment NN cord-015306-us58wwmp 1230 40 group group NN cord-015306-us58wwmp 1230 41 , , , cord-015306-us58wwmp 1230 42 and and CC cord-015306-us58wwmp 1230 43 prednisone prednisone NNP cord-015306-us58wwmp 1230 44 plus plus CC cord-015306-us58wwmp 1230 45 1,25(OH)2D3 1,25(oh)2d3 CD cord-015306-us58wwmp 1230 46 treatment treatment NN cord-015306-us58wwmp 1230 47 group group NN cord-015306-us58wwmp 1230 48 . . . cord-015306-us58wwmp 1231 1 In in IN cord-015306-us58wwmp 1231 2 addition addition NN cord-015306-us58wwmp 1231 3 , , , cord-015306-us58wwmp 1231 4 the the DT cord-015306-us58wwmp 1231 5 1,25(OH)2D3 1,25(oh)2d3 CD cord-015306-us58wwmp 1231 6 and and CC cord-015306-us58wwmp 1231 7 prednisone prednisone NN cord-015306-us58wwmp 1231 8 plus plus CC cord-015306-us58wwmp 1231 9 1,25(OH)2D3 1,25(oh)2d3 CD cord-015306-us58wwmp 1231 10 treatment treatment NN cord-015306-us58wwmp 1231 11 groups group NNS cord-015306-us58wwmp 1231 12 showed show VBD cord-015306-us58wwmp 1231 13 lower low JJR cord-015306-us58wwmp 1231 14 levels level NNS cord-015306-us58wwmp 1231 15 than than IN cord-015306-us58wwmp 1231 16 the the DT cord-015306-us58wwmp 1231 17 prednisone prednisone NNP cord-015306-us58wwmp 1231 18 treatment treatment NNP cord-015306-us58wwmp 1231 19 group group NNP cord-015306-us58wwmp 1231 20 ( ( -LRB- cord-015306-us58wwmp 1231 21 P p NN cord-015306-us58wwmp 1231 22 < < XX cord-015306-us58wwmp 1231 23 0.05 0.05 CD cord-015306-us58wwmp 1231 24 ) ) -RRB- cord-015306-us58wwmp 1231 25 . . . cord-015306-us58wwmp 1232 1 ( ( -LRB- cord-015306-us58wwmp 1232 2 3 3 LS cord-015306-us58wwmp 1232 3 ) ) -RRB- cord-015306-us58wwmp 1233 1 The the DT cord-015306-us58wwmp 1233 2 level level NN cord-015306-us58wwmp 1233 3 of of IN cord-015306-us58wwmp 1233 4 Treg Treg NNP cord-015306-us58wwmp 1233 5 cells cell NNS cord-015306-us58wwmp 1233 6 in in IN cord-015306-us58wwmp 1233 7 the the DT cord-015306-us58wwmp 1233 8 model model NN cord-015306-us58wwmp 1233 9 group group NN cord-015306-us58wwmp 1233 10 was be VBD cord-015306-us58wwmp 1233 11 significantly significantly RB cord-015306-us58wwmp 1233 12 decreased decrease VBN cord-015306-us58wwmp 1233 13 compared compare VBN cord-015306-us58wwmp 1233 14 with with IN cord-015306-us58wwmp 1233 15 the the DT cord-015306-us58wwmp 1233 16 control control NN cord-015306-us58wwmp 1233 17 and and CC cord-015306-us58wwmp 1233 18 treatment treatment NN cord-015306-us58wwmp 1233 19 groups group NNS cord-015306-us58wwmp 1233 20 ( ( -LRB- cord-015306-us58wwmp 1233 21 P p NN cord-015306-us58wwmp 1233 22 < < XX cord-015306-us58wwmp 1233 23 0.01 0.01 CD cord-015306-us58wwmp 1233 24 ) ) -RRB- cord-015306-us58wwmp 1233 25 , , , cord-015306-us58wwmp 1233 26 with with IN cord-015306-us58wwmp 1233 27 the the DT cord-015306-us58wwmp 1233 28 levels level NNS cord-015306-us58wwmp 1233 29 showing show VBG cord-015306-us58wwmp 1233 30 a a DT cord-015306-us58wwmp 1233 31 slight slight JJ cord-015306-us58wwmp 1233 32 increase increase NN cord-015306-us58wwmp 1233 33 in in IN cord-015306-us58wwmp 1233 34 the the DT cord-015306-us58wwmp 1233 35 prednisone prednisone NNP cord-015306-us58wwmp 1233 36 treatment treatment NNP cord-015306-us58wwmp 1233 37 group group NNP cord-015306-us58wwmp 1233 38 , , , cord-015306-us58wwmp 1233 39 a a DT cord-015306-us58wwmp 1233 40 larger large JJR cord-015306-us58wwmp 1233 41 increase increase NN cord-015306-us58wwmp 1233 42 in in IN cord-015306-us58wwmp 1233 43 the the DT cord-015306-us58wwmp 1233 44 1,25(OH)2D3 1,25(oh)2d3 CD cord-015306-us58wwmp 1233 45 treatment treatment NN cord-015306-us58wwmp 1233 46 group group NN cord-015306-us58wwmp 1233 47 , , , cord-015306-us58wwmp 1233 48 and and CC cord-015306-us58wwmp 1233 49 the the DT cord-015306-us58wwmp 1233 50 greatest great JJS cord-015306-us58wwmp 1233 51 increase increase NN cord-015306-us58wwmp 1233 52 in in IN cord-015306-us58wwmp 1233 53 the the DT cord-015306-us58wwmp 1233 54 prednisone prednisone NNP cord-015306-us58wwmp 1233 55 plus plus CC cord-015306-us58wwmp 1233 56 1,25(OH)2D3 1,25(oh)2d3 CD cord-015306-us58wwmp 1233 57 treatment treatment NN cord-015306-us58wwmp 1233 58 group group NN cord-015306-us58wwmp 1233 59 when when WRB cord-015306-us58wwmp 1233 60 compared compare VBN cord-015306-us58wwmp 1233 61 with with IN cord-015306-us58wwmp 1233 62 the the DT cord-015306-us58wwmp 1233 63 model model NN cord-015306-us58wwmp 1233 64 group group NN cord-015306-us58wwmp 1233 65 . . . cord-015306-us58wwmp 1234 1 Furthermore furthermore RB cord-015306-us58wwmp 1234 2 , , , cord-015306-us58wwmp 1234 3 the the DT cord-015306-us58wwmp 1234 4 1,25(OH)2D3 1,25(oh)2d3 CD cord-015306-us58wwmp 1234 5 group group NN cord-015306-us58wwmp 1234 6 and and CC cord-015306-us58wwmp 1234 7 prednisone prednisone NNP cord-015306-us58wwmp 1234 8 plus plus CC cord-015306-us58wwmp 1234 9 1,25(OH)2D3 1,25(oh)2d3 CD cord-015306-us58wwmp 1234 10 treatment treatment NN cord-015306-us58wwmp 1234 11 groups group NNS cord-015306-us58wwmp 1234 12 showed show VBD cord-015306-us58wwmp 1234 13 higher high JJR cord-015306-us58wwmp 1234 14 levels level NNS cord-015306-us58wwmp 1234 15 than than IN cord-015306-us58wwmp 1234 16 the the DT cord-015306-us58wwmp 1234 17 prednisone prednisone NNP cord-015306-us58wwmp 1234 18 treatment treatment NNP cord-015306-us58wwmp 1234 19 group group NNP cord-015306-us58wwmp 1234 20 ( ( -LRB- cord-015306-us58wwmp 1234 21 P p NN cord-015306-us58wwmp 1234 22 < < XX cord-015306-us58wwmp 1234 23 0.01 0.01 CD cord-015306-us58wwmp 1234 24 ) ) -RRB- cord-015306-us58wwmp 1234 25 . . . cord-015306-us58wwmp 1235 1 Conclusion conclusion NN cord-015306-us58wwmp 1235 2 : : : cord-015306-us58wwmp 1236 1 A a DT cord-015306-us58wwmp 1236 2 Th17 th17 NN cord-015306-us58wwmp 1237 1 /Treg /Treg NFP cord-015306-us58wwmp 1237 2 disorder disorder NN cord-015306-us58wwmp 1237 3 exists exist VBZ cord-015306-us58wwmp 1237 4 in in IN cord-015306-us58wwmp 1237 5 rats rat NNS cord-015306-us58wwmp 1237 6 with with IN cord-015306-us58wwmp 1237 7 IgA IgA NNP cord-015306-us58wwmp 1237 8 nephropathy nephropathy NNP cord-015306-us58wwmp 1237 9 , , , cord-015306-us58wwmp 1237 10 with with IN cord-015306-us58wwmp 1237 11 the the DT cord-015306-us58wwmp 1237 12 levels level NNS cord-015306-us58wwmp 1237 13 of of IN cord-015306-us58wwmp 1237 14 interleukin-17 interleukin-17 NN cord-015306-us58wwmp 1237 15 increased increase VBN cord-015306-us58wwmp 1237 16 and and CC cord-015306-us58wwmp 1237 17 the the DT cord-015306-us58wwmp 1237 18 levels level NNS cord-015306-us58wwmp 1237 19 of of IN cord-015306-us58wwmp 1237 20 Treg Treg NNP cord-015306-us58wwmp 1237 21 cells cell NNS cord-015306-us58wwmp 1237 22 decreased decrease VBD cord-015306-us58wwmp 1237 23 . . . cord-015306-us58wwmp 1238 1 Vitamin vitamin NN cord-015306-us58wwmp 1238 2 D3 D3 NNP cord-015306-us58wwmp 1238 3 can can MD cord-015306-us58wwmp 1238 4 regulate regulate VB cord-015306-us58wwmp 1238 5 the the DT cord-015306-us58wwmp 1238 6 Th17 Th17 NNP cord-015306-us58wwmp 1238 7 / / SYM cord-015306-us58wwmp 1238 8 Treg Treg NNP cord-015306-us58wwmp 1238 9 balance balance NN cord-015306-us58wwmp 1238 10 and and CC cord-015306-us58wwmp 1238 11 reduce reduce VB cord-015306-us58wwmp 1238 12 the the DT cord-015306-us58wwmp 1238 13 level level NN cord-015306-us58wwmp 1238 14 of of IN cord-015306-us58wwmp 1238 15 protein protein NN cord-015306-us58wwmp 1238 16 and and CC cord-015306-us58wwmp 1238 17 blood blood NN cord-015306-us58wwmp 1238 18 in in IN cord-015306-us58wwmp 1238 19 the the DT cord-015306-us58wwmp 1238 20 urine urine NN cord-015306-us58wwmp 1238 21 in in IN cord-015306-us58wwmp 1238 22 rats rat NNS cord-015306-us58wwmp 1238 23 with with IN cord-015306-us58wwmp 1238 24 IgA IgA NNP cord-015306-us58wwmp 1238 25 nephropathy nephropathy NNP cord-015306-us58wwmp 1238 26 . . . cord-015306-us58wwmp 1239 1 Objective objective NN cord-015306-us58wwmp 1239 2 : : : cord-015306-us58wwmp 1239 3 To to TO cord-015306-us58wwmp 1239 4 explore explore VB cord-015306-us58wwmp 1239 5 the the DT cord-015306-us58wwmp 1239 6 therapeutic therapeutic JJ cord-015306-us58wwmp 1239 7 effect effect NN cord-015306-us58wwmp 1239 8 of of IN cord-015306-us58wwmp 1239 9 prednisone prednisone NN cord-015306-us58wwmp 1239 10 ( ( -LRB- cord-015306-us58wwmp 1239 11 Pred Pred NNP cord-015306-us58wwmp 1239 12 ) ) -RRB- cord-015306-us58wwmp 1239 13 combined combine VBN cord-015306-us58wwmp 1239 14 with with IN cord-015306-us58wwmp 1239 15 Mycophenolate Mycophenolate NNP cord-015306-us58wwmp 1239 16 Mofetil Mofetil NNP cord-015306-us58wwmp 1239 17 ( ( -LRB- cord-015306-us58wwmp 1239 18 MMF MMF NNP cord-015306-us58wwmp 1239 19 ) ) -RRB- cord-015306-us58wwmp 1239 20 and and CC cord-015306-us58wwmp 1239 21 Cyclosiporin Cyclosiporin NNP cord-015306-us58wwmp 1239 22 A(CsA A(CsA NNP cord-015306-us58wwmp 1239 23 ) ) -RRB- cord-015306-us58wwmp 1239 24 in in IN cord-015306-us58wwmp 1239 25 children child NNS cord-015306-us58wwmp 1239 26 with with IN cord-015306-us58wwmp 1239 27 severe severe JJ cord-015306-us58wwmp 1239 28 purpura purpura NN cord-015306-us58wwmp 1239 29 nephritis nephritis NN cord-015306-us58wwmp 1239 30 ( ( -LRB- cord-015306-us58wwmp 1239 31 HSPN HSPN NNP cord-015306-us58wwmp 1239 32 ) ) -RRB- cord-015306-us58wwmp 1239 33 . . . cord-015306-us58wwmp 1240 1 Methods method NNS cord-015306-us58wwmp 1240 2 : : : cord-015306-us58wwmp 1240 3 we -PRON- PRP cord-015306-us58wwmp 1240 4 collected collect VBD cord-015306-us58wwmp 1240 5 6 6 CD cord-015306-us58wwmp 1240 6 patients patient NNS cord-015306-us58wwmp 1240 7 with with IN cord-015306-us58wwmp 1240 8 severe severe JJ cord-015306-us58wwmp 1240 9 HSPN HSPN NNP cord-015306-us58wwmp 1240 10 ( ( -LRB- cord-015306-us58wwmp 1240 11 from from IN cord-015306-us58wwmp 1240 12 ISKDC ISKDC NNP cord-015306-us58wwmp 1240 13 IIIa iiia NN cord-015306-us58wwmp 1240 14 to to IN cord-015306-us58wwmp 1240 15 I i NN cord-015306-us58wwmp 1240 16 ) ) -RRB- cord-015306-us58wwmp 1241 1 whose whose WP$ cord-015306-us58wwmp 1241 2 proteinuria proteinuria NN cord-015306-us58wwmp 1241 3 symptom symptom NN cord-015306-us58wwmp 1241 4 of of IN cord-015306-us58wwmp 1241 5 Nephrotic Nephrotic NNP cord-015306-us58wwmp 1241 6 Syndrome Syndrome NNP cord-015306-us58wwmp 1241 7 did do VBD cord-015306-us58wwmp 1241 8 not not RB cord-015306-us58wwmp 1241 9 significantly significantly RB cord-015306-us58wwmp 1241 10 relieve relieve VB cord-015306-us58wwmp 1241 11 after after IN cord-015306-us58wwmp 1241 12 4 4 CD cord-015306-us58wwmp 1241 13 weeks week NNS cord-015306-us58wwmp 1241 14 which which WDT cord-015306-us58wwmp 1241 15 treated treat VBD cord-015306-us58wwmp 1241 16 with with IN cord-015306-us58wwmp 1241 17 oral oral JJ cord-015306-us58wwmp 1241 18 Pred Pred NNP cord-015306-us58wwmp 1241 19 and and CC cord-015306-us58wwmp 1241 20 MMF mmf NN cord-015306-us58wwmp 1241 21 ( ( -LRB- cord-015306-us58wwmp 1241 22 20 20 CD cord-015306-us58wwmp 1241 23 - - SYM cord-015306-us58wwmp 1241 24 30 30 CD cord-015306-us58wwmp 1241 25 mg/(kg.d mg/(kg.d NN cord-015306-us58wwmp 1241 26 ) ) -RRB- cord-015306-us58wwmp 1241 27 ) ) -RRB- cord-015306-us58wwmp 1241 28 ; ; : cord-015306-us58wwmp 1241 29 and and CC cord-015306-us58wwmp 1241 30 ( ( -LRB- cord-015306-us58wwmp 1241 31 or or CC cord-015306-us58wwmp 1241 32 ) ) -RRB- cord-015306-us58wwmp 1241 33 the the DT cord-015306-us58wwmp 1241 34 gross gross JJ cord-015306-us58wwmp 1241 35 hematuria hematuria NN cord-015306-us58wwmp 1241 36 did do VBD cord-015306-us58wwmp 1241 37 not not RB cord-015306-us58wwmp 1241 38 disappear disappear VB cord-015306-us58wwmp 1241 39 after after IN cord-015306-us58wwmp 1241 40 2 2 CD cord-015306-us58wwmp 1241 41 courses course NNS cord-015306-us58wwmp 1241 42 which which WDT cord-015306-us58wwmp 1241 43 treated treat VBN cord-015306-us58wwmp 1241 44 with with IN cord-015306-us58wwmp 1241 45 large large JJ cord-015306-us58wwmp 1241 46 doses dose NNS cord-015306-us58wwmp 1241 47 of of IN cord-015306-us58wwmp 1241 48 methylprednisolone methylprednisolone NNP cord-015306-us58wwmp 1241 49 . . . cord-015306-us58wwmp 1242 1 All all DT cord-015306-us58wwmp 1242 2 patients patient NNS cord-015306-us58wwmp 1242 3 were be VBD cord-015306-us58wwmp 1242 4 treated treat VBN cord-015306-us58wwmp 1242 5 with with IN cord-015306-us58wwmp 1242 6 oral oral JJ cord-015306-us58wwmp 1242 7 CsA CsA NNP cord-015306-us58wwmp 1242 8 2 2 CD cord-015306-us58wwmp 1242 9 - - HYPH cord-015306-us58wwmp 1242 10 4mg/(kg.d 4mg/(kg.d CD cord-015306-us58wwmp 1242 11 ) ) -RRB- cord-015306-us58wwmp 1242 12 to to TO cord-015306-us58wwmp 1242 13 induce induce VB cord-015306-us58wwmp 1242 14 remission remission NN cord-015306-us58wwmp 1242 15 therapy therapy NN cord-015306-us58wwmp 1242 16 for for IN cord-015306-us58wwmp 1242 17 3 3 CD cord-015306-us58wwmp 1242 18 - - SYM cord-015306-us58wwmp 1242 19 6 6 CD cord-015306-us58wwmp 1242 20 months month NNS cord-015306-us58wwmp 1242 21 , , , cord-015306-us58wwmp 1242 22 then then RB cord-015306-us58wwmp 1242 23 gradually gradually RB cord-015306-us58wwmp 1242 24 reduced reduce VBD cord-015306-us58wwmp 1242 25 CsA csa NN cord-015306-us58wwmp 1242 26 to to IN cord-015306-us58wwmp 1242 27 1 1 CD cord-015306-us58wwmp 1242 28 - - SYM cord-015306-us58wwmp 1242 29 3 3 CD cord-015306-us58wwmp 1242 30 mg/(kg.d mg/(kg.d NN cord-015306-us58wwmp 1242 31 ) ) -RRB- cord-015306-us58wwmp 1242 32 . . . cord-015306-us58wwmp 1243 1 The the DT cord-015306-us58wwmp 1243 2 follow follow NN cord-015306-us58wwmp 1243 3 - - HYPH cord-015306-us58wwmp 1243 4 up up NN cord-015306-us58wwmp 1243 5 was be VBD cord-015306-us58wwmp 1243 6 8 8 CD cord-015306-us58wwmp 1243 7 - - SYM cord-015306-us58wwmp 1243 8 30 30 CD cord-015306-us58wwmp 1243 9 months month NNS cord-015306-us58wwmp 1243 10 . . . cord-015306-us58wwmp 1244 1 Results result NNS cord-015306-us58wwmp 1244 2 : : : cord-015306-us58wwmp 1245 1 Combined combine VBN cord-015306-us58wwmp 1245 2 therapy therapy NN cord-015306-us58wwmp 1245 3 with with IN cord-015306-us58wwmp 1245 4 immunosuppressant immunosuppressant NN cord-015306-us58wwmp 1245 5 treated treat VBD cord-015306-us58wwmp 1245 6 a a DT cord-015306-us58wwmp 1245 7 month month NN cord-015306-us58wwmp 1245 8 later later RB cord-015306-us58wwmp 1245 9 , , , cord-015306-us58wwmp 1245 10 gross gross JJ cord-015306-us58wwmp 1245 11 hematuria hematuria NN cord-015306-us58wwmp 1245 12 were be VBD cord-015306-us58wwmp 1245 13 disappeared disappear VBN cord-015306-us58wwmp 1245 14 in in IN cord-015306-us58wwmp 1245 15 all all DT cord-015306-us58wwmp 1245 16 5 5 CD cord-015306-us58wwmp 1245 17 patients patient NNS cord-015306-us58wwmp 1245 18 , , , cord-015306-us58wwmp 1245 19 1 1 CD cord-015306-us58wwmp 1245 20 patient patient NN cord-015306-us58wwmp 1245 21 ( ( -LRB- cord-015306-us58wwmp 1245 22 17 17 CD cord-015306-us58wwmp 1245 23 % % NN cord-015306-us58wwmp 1245 24 ) ) -RRB- cord-015306-us58wwmp 1245 25 was be VBD cord-015306-us58wwmp 1245 26 partial partial JJ cord-015306-us58wwmp 1245 27 remission remission NN cord-015306-us58wwmp 1245 28 ( ( -LRB- cord-015306-us58wwmp 1246 1 urinary urinary JJ cord-015306-us58wwmp 1246 2 protein protein NN cord-015306-us58wwmp 1246 3 and and CC cord-015306-us58wwmp 1246 4 urine urine NN cord-015306-us58wwmp 1246 5 erythrocyte erythrocyte NN cord-015306-us58wwmp 1246 6 continued continue VBD cord-015306-us58wwmp 1246 7 to to TO cord-015306-us58wwmp 1246 8 decrease decrease VB cord-015306-us58wwmp 1246 9 25%-49 25%-49 CD cord-015306-us58wwmp 1246 10 % % NN cord-015306-us58wwmp 1246 11 than than IN cord-015306-us58wwmp 1246 12 before),5 before),5 NNS cord-015306-us58wwmp 1247 1 patients patient NNS cord-015306-us58wwmp 1247 2 ( ( -LRB- cord-015306-us58wwmp 1247 3 83 83 CD cord-015306-us58wwmp 1247 4 % % NN cord-015306-us58wwmp 1247 5 ) ) -RRB- cord-015306-us58wwmp 1247 6 were be VBD cord-015306-us58wwmp 1247 7 significantly significantly RB cord-015306-us58wwmp 1247 8 remission remission NN cord-015306-us58wwmp 1247 9 ( ( -LRB- cord-015306-us58wwmp 1248 1 urinary urinary JJ cord-015306-us58wwmp 1248 2 protein protein NN cord-015306-us58wwmp 1248 3 and and CC cord-015306-us58wwmp 1248 4 urine urine NN cord-015306-us58wwmp 1248 5 erythrocyte erythrocyte NN cord-015306-us58wwmp 1248 6 continued continue VBD cord-015306-us58wwmp 1248 7 to to TO cord-015306-us58wwmp 1248 8 decrease decrease VB cord-015306-us58wwmp 1248 9 over over IN cord-015306-us58wwmp 1248 10 50 50 CD cord-015306-us58wwmp 1248 11 % % NN cord-015306-us58wwmp 1248 12 than than IN cord-015306-us58wwmp 1248 13 before before RB cord-015306-us58wwmp 1248 14 ) ) -RRB- cord-015306-us58wwmp 1248 15 , , , cord-015306-us58wwmp 1248 16 24-hour 24-hour JJ cord-015306-us58wwmp 1248 17 urinary urinary JJ cord-015306-us58wwmp 1248 18 protein protein NN cord-015306-us58wwmp 1248 19 was be VBD cord-015306-us58wwmp 1248 20 30.50±19.35mg 30.50±19.35mg CD cord-015306-us58wwmp 1248 21 / / SYM cord-015306-us58wwmp 1248 22 kg kg NN cord-015306-us58wwmp 1248 23 , , , cord-015306-us58wwmp 1248 24 urine urine NN cord-015306-us58wwmp 1248 25 erythrocyte erythrocyte NN cord-015306-us58wwmp 1248 26 was be VBD cord-015306-us58wwmp 1248 27 15.23±11.39×10 15.23±11.39×10 CD cord-015306-us58wwmp 1248 28 4 4 CD cord-015306-us58wwmp 1249 1 /ml.3 /ml.3 JJ cord-015306-us58wwmp 1249 2 months month NNS cord-015306-us58wwmp 1249 3 later later RB cord-015306-us58wwmp 1249 4 , , , cord-015306-us58wwmp 1249 5 5 5 CD cord-015306-us58wwmp 1249 6 patients patient NNS cord-015306-us58wwmp 1249 7 ( ( -LRB- cord-015306-us58wwmp 1249 8 83 83 CD cord-015306-us58wwmp 1249 9 % % NN cord-015306-us58wwmp 1249 10 ) ) -RRB- cord-015306-us58wwmp 1249 11 were be VBD cord-015306-us58wwmp 1249 12 significantly significantly RB cord-015306-us58wwmp 1249 13 remission remission NN cord-015306-us58wwmp 1249 14 , , , cord-015306-us58wwmp 1249 15 1 1 CD cord-015306-us58wwmp 1249 16 patient patient NN cord-015306-us58wwmp 1249 17 was be VBD cord-015306-us58wwmp 1249 18 complete complete JJ cord-015306-us58wwmp 1249 19 remission remission NN cord-015306-us58wwmp 1249 20 ( ( -LRB- cord-015306-us58wwmp 1249 21 urinary urinary JJ cord-015306-us58wwmp 1249 22 protein protein NN cord-015306-us58wwmp 1249 23 was be VBD cord-015306-us58wwmp 1249 24 completely completely RB cord-015306-us58wwmp 1249 25 negative negative JJ cord-015306-us58wwmp 1249 26 , , , cord-015306-us58wwmp 1249 27 urinary urinary JJ cord-015306-us58wwmp 1249 28 sediment sediment NN cord-015306-us58wwmp 1249 29 red red JJ cord-015306-us58wwmp 1249 30 blood blood NN cord-015306-us58wwmp 1249 31 cells cell NNS cord-015306-us58wwmp 1250 1 < < XX cord-015306-us58wwmp 1250 2 8000 8000 CD cord-015306-us58wwmp 1250 3 / / SYM cord-015306-us58wwmp 1250 4 ml ml NN cord-015306-us58wwmp 1250 5 ) ) -RRB- cord-015306-us58wwmp 1250 6 , , , cord-015306-us58wwmp 1250 7 24-hour 24-hour JJ cord-015306-us58wwmp 1250 8 urinary urinary JJ cord-015306-us58wwmp 1250 9 protein protein NN cord-015306-us58wwmp 1250 10 was be VBD cord-015306-us58wwmp 1250 11 18.67±10.10mg 18.67±10.10mg NNP cord-015306-us58wwmp 1250 12 / / SYM cord-015306-us58wwmp 1250 13 kg kg NN cord-015306-us58wwmp 1250 14 , , , cord-015306-us58wwmp 1250 15 urine urine NN cord-015306-us58wwmp 1250 16 erythrocyte erythrocyte NN cord-015306-us58wwmp 1250 17 was be VBD cord-015306-us58wwmp 1250 18 10.71±8.55×10 10.71±8.55×10 CD cord-015306-us58wwmp 1250 19 4 4 CD cord-015306-us58wwmp 1250 20 /ml /ml . cord-015306-us58wwmp 1250 21 . . . cord-015306-us58wwmp 1251 1 6 6 CD cord-015306-us58wwmp 1251 2 months month NNS cord-015306-us58wwmp 1251 3 later later RB cord-015306-us58wwmp 1251 4 , , , cord-015306-us58wwmp 1251 5 5 5 CD cord-015306-us58wwmp 1251 6 patients patient NNS cord-015306-us58wwmp 1251 7 ( ( -LRB- cord-015306-us58wwmp 1251 8 83 83 CD cord-015306-us58wwmp 1251 9 % % NN cord-015306-us58wwmp 1251 10 ) ) -RRB- cord-015306-us58wwmp 1251 11 were be VBD cord-015306-us58wwmp 1251 12 significantly significantly RB cord-015306-us58wwmp 1251 13 remission remission NN cord-015306-us58wwmp 1251 14 , , , cord-015306-us58wwmp 1251 15 1 1 CD cord-015306-us58wwmp 1251 16 patient patient NN cord-015306-us58wwmp 1251 17 was be VBD cord-015306-us58wwmp 1251 18 complete complete JJ cord-015306-us58wwmp 1251 19 remission remission NN cord-015306-us58wwmp 1251 20 , , , cord-015306-us58wwmp 1251 21 24-hour 24-hour JJ cord-015306-us58wwmp 1251 22 urinary urinary JJ cord-015306-us58wwmp 1251 23 protein protein NN cord-015306-us58wwmp 1251 24 was be VBD cord-015306-us58wwmp 1251 25 7.66±6.31mg 7.66±6.31mg NNP cord-015306-us58wwmp 1251 26 / / SYM cord-015306-us58wwmp 1251 27 kg kg NN cord-015306-us58wwmp 1251 28 , , , cord-015306-us58wwmp 1251 29 urine urine NN cord-015306-us58wwmp 1251 30 erythrocyte erythrocyte NN cord-015306-us58wwmp 1251 31 was be VBD cord-015306-us58wwmp 1251 32 5.18±3.81×10 5.18±3.81×10 CD cord-015306-us58wwmp 1251 33 4 4 CD cord-015306-us58wwmp 1251 34 /ml /ml . cord-015306-us58wwmp 1251 35 . . . cord-015306-us58wwmp 1252 1 4 4 CD cord-015306-us58wwmp 1252 2 patients patient NNS cord-015306-us58wwmp 1252 3 were be VBD cord-015306-us58wwmp 1252 4 complete complete JJ cord-015306-us58wwmp 1252 5 remission remission NN cord-015306-us58wwmp 1252 6 at at IN cord-015306-us58wwmp 1252 7 last last JJ cord-015306-us58wwmp 1252 8 and and CC cord-015306-us58wwmp 1252 9 the the DT cord-015306-us58wwmp 1252 10 median median JJ cord-015306-us58wwmp 1252 11 duration duration NN cord-015306-us58wwmp 1252 12 of of IN cord-015306-us58wwmp 1252 13 complete complete JJ cord-015306-us58wwmp 1252 14 remission remission NN cord-015306-us58wwmp 1252 15 was be VBD cord-015306-us58wwmp 1252 16 8.5±4.93 8.5±4.93 CD cord-015306-us58wwmp 1252 17 months month NNS cord-015306-us58wwmp 1252 18 . . . cord-015306-us58wwmp 1253 1 2 2 CD cord-015306-us58wwmp 1253 2 patients patient NNS cord-015306-us58wwmp 1253 3 had have VBD cord-015306-us58wwmp 1253 4 not not RB cord-015306-us58wwmp 1253 5 been be VBN cord-015306-us58wwmp 1253 6 reached reach VBN cord-015306-us58wwmp 1253 7 complete complete JJ cord-015306-us58wwmp 1253 8 remission remission NN cord-015306-us58wwmp 1253 9 , , , cord-015306-us58wwmp 1253 10 which which WDT cord-015306-us58wwmp 1253 11 follow follow NN cord-015306-us58wwmp 1253 12 - - HYPH cord-015306-us58wwmp 1253 13 up up NN cord-015306-us58wwmp 1253 14 was be VBD cord-015306-us58wwmp 1253 15 8 8 CD cord-015306-us58wwmp 1253 16 - - SYM cord-015306-us58wwmp 1253 17 9 9 CD cord-015306-us58wwmp 1253 18 months month NNS cord-015306-us58wwmp 1253 19 . . . cord-015306-us58wwmp 1254 1 3 3 CD cord-015306-us58wwmp 1254 2 patients patient NNS cord-015306-us58wwmp 1254 3 were be VBD cord-015306-us58wwmp 1254 4 relapse relapse VBN cord-015306-us58wwmp 1254 5 during during IN cord-015306-us58wwmp 1254 6 withdraw withdraw NN cord-015306-us58wwmp 1254 7 or or CC cord-015306-us58wwmp 1254 8 reduction reduction NN cord-015306-us58wwmp 1254 9 , , , cord-015306-us58wwmp 1254 10 other other JJ cord-015306-us58wwmp 1254 11 side side NN cord-015306-us58wwmp 1254 12 effects effect NNS cord-015306-us58wwmp 1254 13 included include VBD cord-015306-us58wwmp 1254 14 hairy hairy JJ cord-015306-us58wwmp 1254 15 ( ( -LRB- cord-015306-us58wwmp 1254 16 4 4 CD cord-015306-us58wwmp 1254 17 patients patient NNS cord-015306-us58wwmp 1255 1 Objective objective JJ cord-015306-us58wwmp 1256 1 : : : cord-015306-us58wwmp 1256 2 Increasing increase VBG cord-015306-us58wwmp 1256 3 evidence evidence NN cord-015306-us58wwmp 1256 4 suggest suggest VBP cord-015306-us58wwmp 1256 5 that that IN cord-015306-us58wwmp 1256 6 the the DT cord-015306-us58wwmp 1256 7 Cosmc(1-beta-3galactosyltransferase cosmc(1-beta-3galactosyltransferase JJ cord-015306-us58wwmp 1256 8 - - HYPH cord-015306-us58wwmp 1256 9 specific specific JJ cord-015306-us58wwmp 1256 10 molecular molecular JJ cord-015306-us58wwmp 1256 11 chaperone chaperone NN cord-015306-us58wwmp 1256 12 ) ) -RRB- cord-015306-us58wwmp 1256 13 might may MD cord-015306-us58wwmp 1256 14 play play VB cord-015306-us58wwmp 1256 15 a a DT cord-015306-us58wwmp 1256 16 vital vital JJ cord-015306-us58wwmp 1256 17 role role NN cord-015306-us58wwmp 1256 18 in in IN cord-015306-us58wwmp 1256 19 the the DT cord-015306-us58wwmp 1256 20 pathogenesis pathogenesis NN cord-015306-us58wwmp 1256 21 of of IN cord-015306-us58wwmp 1256 22 IgA IgA NNP cord-015306-us58wwmp 1256 23 nephropathy nephropathy NNP cord-015306-us58wwmp 1256 24 ( ( -LRB- cord-015306-us58wwmp 1256 25 IgAN IgAN NNP cord-015306-us58wwmp 1256 26 ) ) -RRB- cord-015306-us58wwmp 1256 27 . . . cord-015306-us58wwmp 1257 1 However however RB cord-015306-us58wwmp 1257 2 , , , cord-015306-us58wwmp 1257 3 the the DT cord-015306-us58wwmp 1257 4 mechanism mechanism NN cord-015306-us58wwmp 1257 5 is be VBZ cord-015306-us58wwmp 1257 6 not not RB cord-015306-us58wwmp 1257 7 clear clear JJ cord-015306-us58wwmp 1257 8 . . . cord-015306-us58wwmp 1258 1 Methods method NNS cord-015306-us58wwmp 1258 2 : : : cord-015306-us58wwmp 1258 3 We -PRON- PRP cord-015306-us58wwmp 1258 4 investigated investigate VBD cord-015306-us58wwmp 1258 5 whether whether IN cord-015306-us58wwmp 1258 6 Cosmc Cosmc NNP cord-015306-us58wwmp 1258 7 gene gene NN cord-015306-us58wwmp 1258 8 ( ( -LRB- cord-015306-us58wwmp 1258 9 C1GALT1C1 c1galt1c1 NN cord-015306-us58wwmp 1258 10 ) ) -RRB- cord-015306-us58wwmp 1258 11 methylation methylation NN cord-015306-us58wwmp 1258 12 is be VBZ cord-015306-us58wwmp 1258 13 an an DT cord-015306-us58wwmp 1258 14 important important JJ cord-015306-us58wwmp 1258 15 mechanism mechanism NN cord-015306-us58wwmp 1258 16 in in IN cord-015306-us58wwmp 1258 17 IgAN IgAN NNP cord-015306-us58wwmp 1258 18 in in IN cord-015306-us58wwmp 1258 19 children child NNS cord-015306-us58wwmp 1258 20 . . . cord-015306-us58wwmp 1259 1 Methods method NNS cord-015306-us58wwmp 1259 2 33(M 33(m CD cord-015306-us58wwmp 1259 3 : : : cord-015306-us58wwmp 1259 4 F=25:8 F=25:8 NNP cord-015306-us58wwmp 1259 5 ) ) -RRB- cord-015306-us58wwmp 1259 6 primaryIgAN primaryigan XX cord-015306-us58wwmp 1260 1 children child NNS cord-015306-us58wwmp 1260 2 and and CC cord-015306-us58wwmp 1260 3 39(M 39(m CD cord-015306-us58wwmp 1260 4 : : : cord-015306-us58wwmp 1260 5 F=28:11 f=28:11 CD cord-015306-us58wwmp 1260 6 ) ) -RRB- cord-015306-us58wwmp 1261 1 healthy healthy JJ cord-015306-us58wwmp 1261 2 controls control NNS cord-015306-us58wwmp 1261 3 were be VBD cord-015306-us58wwmp 1261 4 enrolled enrol VBN cord-015306-us58wwmp 1261 5 randomly randomly RB cord-015306-us58wwmp 1261 6 . . . cord-015306-us58wwmp 1262 1 The the DT cord-015306-us58wwmp 1262 2 methylation methylation NN cord-015306-us58wwmp 1262 3 status status NN cord-015306-us58wwmp 1262 4 of of IN cord-015306-us58wwmp 1262 5 the the DT cord-015306-us58wwmp 1262 6 C1GALT1C1 C1GALT1C1 NNP cord-015306-us58wwmp 1262 7 was be VBD cord-015306-us58wwmp 1262 8 detected detect VBN cord-015306-us58wwmp 1262 9 using use VBG cord-015306-us58wwmp 1262 10 bisulfite bisulfite NN cord-015306-us58wwmp 1262 11 - - HYPH cord-015306-us58wwmp 1262 12 specific specific JJ cord-015306-us58wwmp 1262 13 polymerase polymerase NN cord-015306-us58wwmp 1262 14 chain chain NN cord-015306-us58wwmp 1262 15 reaction reaction NN cord-015306-us58wwmp 1262 16 ( ( -LRB- cord-015306-us58wwmp 1262 17 BSP)-based bsp)-base VBN cord-015306-us58wwmp 1262 18 sequencing sequencing NN cord-015306-us58wwmp 1262 19 analysis analysis NN cord-015306-us58wwmp 1262 20 . . . cord-015306-us58wwmp 1263 1 Results result NNS cord-015306-us58wwmp 1263 2 : : : cord-015306-us58wwmp 1264 1 The the DT cord-015306-us58wwmp 1264 2 male male JJ cord-015306-us58wwmp 1264 3 patients patient NNS cord-015306-us58wwmp 1264 4 had have VBD cord-015306-us58wwmp 1264 5 obviousely obviousely RB cord-015306-us58wwmp 1264 6 high high JJ cord-015306-us58wwmp 1264 7 methylation methylation NN cord-015306-us58wwmp 1264 8 percentage percentage NN cord-015306-us58wwmp 1264 9 than than IN cord-015306-us58wwmp 1264 10 the the DT cord-015306-us58wwmp 1264 11 male male NN cord-015306-us58wwmp 1264 12 controls(p=0.047 controls(p=0.047 NNP cord-015306-us58wwmp 1264 13 ) ) -RRB- cord-015306-us58wwmp 1264 14 . . . cord-015306-us58wwmp 1265 1 Three three CD cord-015306-us58wwmp 1265 2 significant significant JJ cord-015306-us58wwmp 1265 3 hypermethylation hypermethylation NN cord-015306-us58wwmp 1265 4 sites site NNS cord-015306-us58wwmp 1265 5 were be VBD cord-015306-us58wwmp 1265 6 identified identify VBN cord-015306-us58wwmp 1265 7 in in IN cord-015306-us58wwmp 1265 8 the the DT cord-015306-us58wwmp 1265 9 male male JJ cord-015306-us58wwmp 1265 10 patients patient NNS cord-015306-us58wwmp 1265 11 : : : cord-015306-us58wwmp 1265 12 CpG CpG NNP cord-015306-us58wwmp 1265 13 site site NN cord-015306-us58wwmp 1265 14 20 20 CD cord-015306-us58wwmp 1265 15 ( ( -LRB- cord-015306-us58wwmp 1265 16 p p NN cord-015306-us58wwmp 1265 17 = = SYM cord-015306-us58wwmp 1265 18 0.034 0.034 CD cord-015306-us58wwmp 1265 19 ) ) -RRB- cord-015306-us58wwmp 1265 20 , , , cord-015306-us58wwmp 1265 21 site site NN cord-015306-us58wwmp 1265 22 21 21 CD cord-015306-us58wwmp 1265 23 ( ( -LRB- cord-015306-us58wwmp 1265 24 p p NN cord-015306-us58wwmp 1265 25 = = SYM cord-015306-us58wwmp 1265 26 0.039 0.039 CD cord-015306-us58wwmp 1265 27 ) ) -RRB- cord-015306-us58wwmp 1265 28 , , , cord-015306-us58wwmp 1265 29 andsite andsite NNP cord-015306-us58wwmp 1265 30 26 26 CD cord-015306-us58wwmp 1265 31 ( ( -LRB- cord-015306-us58wwmp 1265 32 p p NN cord-015306-us58wwmp 1265 33 = = SYM cord-015306-us58wwmp 1265 34 0.047 0.047 CD cord-015306-us58wwmp 1265 35 ) ) -RRB- cord-015306-us58wwmp 1265 36 . . . cord-015306-us58wwmp 1266 1 In in IN cord-015306-us58wwmp 1266 2 the the DT cord-015306-us58wwmp 1266 3 female female JJ cord-015306-us58wwmp 1266 4 groups group NNS cord-015306-us58wwmp 1266 5 , , , cord-015306-us58wwmp 1266 6 the the DT cord-015306-us58wwmp 1266 7 patients patient NNS cord-015306-us58wwmp 1266 8 and and CC cord-015306-us58wwmp 1266 9 the the DT cord-015306-us58wwmp 1266 10 normal normal JJ cord-015306-us58wwmp 1266 11 controls control NNS cord-015306-us58wwmp 1266 12 all all DT cord-015306-us58wwmp 1266 13 had have VBD cord-015306-us58wwmp 1266 14 high high JJ cord-015306-us58wwmp 1266 15 level level NN cord-015306-us58wwmp 1266 16 methylation methylation NN cord-015306-us58wwmp 1266 17 without without IN cord-015306-us58wwmp 1266 18 significance significance NN cord-015306-us58wwmp 1266 19 ( ( -LRB- cord-015306-us58wwmp 1266 20 p=0.947 p=0.947 NNP cord-015306-us58wwmp 1266 21 ) ) -RRB- cord-015306-us58wwmp 1266 22 . . . cord-015306-us58wwmp 1267 1 Conclusion conclusion NN cord-015306-us58wwmp 1267 2 : : : cord-015306-us58wwmp 1268 1 Methylation methylation NN cord-015306-us58wwmp 1268 2 of of IN cord-015306-us58wwmp 1268 3 C1GALT1C1 C1GALT1C1 NNPS cord-015306-us58wwmp 1268 4 might may MD cord-015306-us58wwmp 1268 5 have have VB cord-015306-us58wwmp 1268 6 the the DT cord-015306-us58wwmp 1268 7 vital vital JJ cord-015306-us58wwmp 1268 8 significance significance NN cord-015306-us58wwmp 1268 9 in in IN cord-015306-us58wwmp 1268 10 the the DT cord-015306-us58wwmp 1268 11 susceptibility susceptibility NN cord-015306-us58wwmp 1268 12 to to IN cord-015306-us58wwmp 1268 13 the the DT cord-015306-us58wwmp 1268 14 male male JJ cord-015306-us58wwmp 1268 15 IgAN IgAN NNP cord-015306-us58wwmp 1268 16 patients patient NNS cord-015306-us58wwmp 1268 17 . . . cord-015306-us58wwmp 1269 1 Objective objective NN cord-015306-us58wwmp 1269 2 : : : cord-015306-us58wwmp 1270 1 The the DT cord-015306-us58wwmp 1270 2 aim aim NN cord-015306-us58wwmp 1270 3 of of IN cord-015306-us58wwmp 1270 4 this this DT cord-015306-us58wwmp 1270 5 research research NN cord-015306-us58wwmp 1270 6 is be VBZ cord-015306-us58wwmp 1270 7 to to TO cord-015306-us58wwmp 1270 8 investigate investigate VB cord-015306-us58wwmp 1270 9 the the DT cord-015306-us58wwmp 1270 10 value value NN cord-015306-us58wwmp 1270 11 of of IN cord-015306-us58wwmp 1270 12 serum serum NN cord-015306-us58wwmp 1270 13 and and CC cord-015306-us58wwmp 1270 14 urinary urinary JJ cord-015306-us58wwmp 1270 15 TGF- tgf- XX cord-015306-us58wwmp 1271 1 β1and β1and XX cord-015306-us58wwmp 1272 1 MMP-9 MMP-9 NNP cord-015306-us58wwmp 1272 2 level level NN cord-015306-us58wwmp 1272 3 , , , cord-015306-us58wwmp 1272 4 the the DT cord-015306-us58wwmp 1272 5 noninvasive noninvasive JJ cord-015306-us58wwmp 1272 6 and and CC cord-015306-us58wwmp 1272 7 easy easy JJ cord-015306-us58wwmp 1272 8 repeatable repeatable JJ cord-015306-us58wwmp 1272 9 biomarker biomarker NN cord-015306-us58wwmp 1272 10 , , , cord-015306-us58wwmp 1272 11 for for IN cord-015306-us58wwmp 1272 12 assessing assess VBG cord-015306-us58wwmp 1272 13 the the DT cord-015306-us58wwmp 1272 14 severity severity NN cord-015306-us58wwmp 1272 15 and and CC cord-015306-us58wwmp 1272 16 disease disease NN cord-015306-us58wwmp 1272 17 progression progression NN cord-015306-us58wwmp 1272 18 in in IN cord-015306-us58wwmp 1272 19 IgAN IgAN NNP cord-015306-us58wwmp 1272 20 children child NNS cord-015306-us58wwmp 1272 21 . . . cord-015306-us58wwmp 1273 1 Methods method NNS cord-015306-us58wwmp 1273 2 : : : cord-015306-us58wwmp 1273 3 54 54 CD cord-015306-us58wwmp 1273 4 children child NNS cord-015306-us58wwmp 1273 5 with with IN cord-015306-us58wwmp 1273 6 biopsy biopsy NN cord-015306-us58wwmp 1273 7 - - HYPH cord-015306-us58wwmp 1273 8 proven prove VBN cord-015306-us58wwmp 1273 9 IgAN IgAN NNP cord-015306-us58wwmp 1273 10 and and CC cord-015306-us58wwmp 1273 11 55 55 CD cord-015306-us58wwmp 1273 12 normal normal JJ cord-015306-us58wwmp 1273 13 children(control children(control NN cord-015306-us58wwmp 1273 14 group group NN cord-015306-us58wwmp 1273 15 ) ) -RRB- cord-015306-us58wwmp 1273 16 were be VBD cord-015306-us58wwmp 1273 17 enrolled enrol VBN cord-015306-us58wwmp 1273 18 between between IN cord-015306-us58wwmp 1273 19 July July NNP cord-015306-us58wwmp 1273 20 2009 2009 CD cord-015306-us58wwmp 1273 21 and and CC cord-015306-us58wwmp 1273 22 January January NNP cord-015306-us58wwmp 1273 23 2013.(Fingure 2013.(fingure CD cord-015306-us58wwmp 1274 1 1)The 1)the CD cord-015306-us58wwmp 1275 1 IgAN IgAN NNP cord-015306-us58wwmp 1275 2 group group NNP cord-015306-us58wwmp 1275 3 was be VBD cord-015306-us58wwmp 1275 4 divided divide VBN cord-015306-us58wwmp 1275 5 into into IN cord-015306-us58wwmp 1275 6 3 3 CD cord-015306-us58wwmp 1275 7 clinical clinical JJ cord-015306-us58wwmp 1275 8 groups group NNS cord-015306-us58wwmp 1275 9 according accord VBG cord-015306-us58wwmp 1275 10 to to IN cord-015306-us58wwmp 1275 11 their -PRON- PRP$ cord-015306-us58wwmp 1275 12 clinical clinical JJ cord-015306-us58wwmp 1275 13 features feature NNS cord-015306-us58wwmp 1275 14 : : : cord-015306-us58wwmp 1275 15 isolated isolate VBN cord-015306-us58wwmp 1275 16 hematuria hematuria NN cord-015306-us58wwmp 1275 17 group group NN cord-015306-us58wwmp 1275 18 ( ( -LRB- cord-015306-us58wwmp 1275 19 IH IH NNP cord-015306-us58wwmp 1275 20 group group NN cord-015306-us58wwmp 1275 21 , , , cord-015306-us58wwmp 1275 22 20 20 CD cord-015306-us58wwmp 1275 23 patients patient NNS cord-015306-us58wwmp 1275 24 ) ) -RRB- cord-015306-us58wwmp 1275 25 , , , cord-015306-us58wwmp 1275 26 hematuria hematuria NN cord-015306-us58wwmp 1275 27 and and CC cord-015306-us58wwmp 1275 28 proteinuria proteinuria NN cord-015306-us58wwmp 1275 29 group group NN cord-015306-us58wwmp 1275 30 ( ( -LRB- cord-015306-us58wwmp 1275 31 HP HP NNP cord-015306-us58wwmp 1275 32 group group NN cord-015306-us58wwmp 1275 33 , , , cord-015306-us58wwmp 1275 34 16 16 CD cord-015306-us58wwmp 1275 35 ) ) -RRB- cord-015306-us58wwmp 1275 36 , , , cord-015306-us58wwmp 1275 37 and and CC cord-015306-us58wwmp 1275 38 nephritic nephritic NNP cord-015306-us58wwmp 1275 39 syndrome syndrome NNP cord-015306-us58wwmp 1275 40 group group NN cord-015306-us58wwmp 1275 41 ( ( -LRB- cord-015306-us58wwmp 1275 42 NS NS NNP cord-015306-us58wwmp 1275 43 group group NN cord-015306-us58wwmp 1275 44 , , , cord-015306-us58wwmp 1275 45 18 18 CD cord-015306-us58wwmp 1275 46 ) ) -RRB- cord-015306-us58wwmp 1275 47 . . . cord-015306-us58wwmp 1276 1 Patients patient NNS cord-015306-us58wwmp 1276 2 were be VBD cord-015306-us58wwmp 1276 3 divided divide VBN cord-015306-us58wwmp 1276 4 into into IN cord-015306-us58wwmp 1276 5 two two CD cord-015306-us58wwmp 1276 6 groups group NNS cord-015306-us58wwmp 1276 7 according accord VBG cord-015306-us58wwmp 1276 8 to to IN cord-015306-us58wwmp 1276 9 their -PRON- PRP$ cord-015306-us58wwmp 1276 10 Lee Lee NNP cord-015306-us58wwmp 1276 11 's 's POS cord-015306-us58wwmp 1276 12 pathologic pathologic JJ cord-015306-us58wwmp 1276 13 classification classification NN cord-015306-us58wwmp 1276 14 : : : cord-015306-us58wwmp 1276 15 grade grade NN cord-015306-us58wwmp 1276 16 I+II I+II NNP cord-015306-us58wwmp 1277 1 ( ( -LRB- cord-015306-us58wwmp 1277 2 Lee Lee NNP cord-015306-us58wwmp 1277 3 's 's POS cord-015306-us58wwmp 1277 4 I+II I+II NNP cord-015306-us58wwmp 1277 5 , , , cord-015306-us58wwmp 1277 6 39 39 CD cord-015306-us58wwmp 1277 7 patients patient NNS cord-015306-us58wwmp 1277 8 ) ) -RRB- cord-015306-us58wwmp 1277 9 , , , cord-015306-us58wwmp 1277 10 grade grade NN cord-015306-us58wwmp 1277 11 III+ III+ NNP cord-015306-us58wwmp 1277 12 IV IV NNP cord-015306-us58wwmp 1278 1 ( ( -LRB- cord-015306-us58wwmp 1278 2 Lee Lee NNP cord-015306-us58wwmp 1278 3 's 's POS cord-015306-us58wwmp 1278 4 III+ III+ NNP cord-015306-us58wwmp 1278 5 IV IV NNP cord-015306-us58wwmp 1278 6 , , , cord-015306-us58wwmp 1278 7 15 15 CD cord-015306-us58wwmp 1278 8 ) ) -RRB- cord-015306-us58wwmp 1278 9 groups group NNS cord-015306-us58wwmp 1278 10 . . . cord-015306-us58wwmp 1279 1 IgAN IgAN NNP cord-015306-us58wwmp 1279 2 group group NNP cord-015306-us58wwmp 1279 3 was be VBD cord-015306-us58wwmp 1279 4 classified classify VBN cord-015306-us58wwmp 1279 5 according accord VBG cord-015306-us58wwmp 1279 6 to to IN cord-015306-us58wwmp 1279 7 the the DT cord-015306-us58wwmp 1279 8 renal renal JJ cord-015306-us58wwmp 1279 9 function function NN cord-015306-us58wwmp 1279 10 into into IN cord-015306-us58wwmp 1279 11 two two CD cord-015306-us58wwmp 1279 12 groups(Renal groups(renal JJ cord-015306-us58wwmp 1279 13 failure failure NN cord-015306-us58wwmp 1279 14 Group Group NNP cord-015306-us58wwmp 1279 15 vs vs IN cord-015306-us58wwmp 1279 16 Normal Normal NNP cord-015306-us58wwmp 1279 17 group group NN cord-015306-us58wwmp 1279 18 ) ) -RRB- cord-015306-us58wwmp 1279 19 . . . cord-015306-us58wwmp 1280 1 IgAN IgAN NNP cord-015306-us58wwmp 1280 2 group group NNP cord-015306-us58wwmp 1280 3 was be VBD cord-015306-us58wwmp 1280 4 also also RB cord-015306-us58wwmp 1280 5 divided divide VBN cord-015306-us58wwmp 1280 6 into into IN cord-015306-us58wwmp 1280 7 four four CD cord-015306-us58wwmp 1280 8 groups group NNS cord-015306-us58wwmp 1280 9 according accord VBG cord-015306-us58wwmp 1280 10 to to IN cord-015306-us58wwmp 1280 11 their -PRON- PRP$ cord-015306-us58wwmp 1280 12 immunophenotype immunophenotype NN cord-015306-us58wwmp 1281 1 : : : cord-015306-us58wwmp 1281 2 IgA(7patients),IgA+IgG(9),IgA+IgM(10),IgA+IgG+IgM(28 iga(7patients),iga+igg(9),iga+igm(10),iga+igg+igm(28 NN cord-015306-us58wwmp 1281 3 ) ) -RRB- cord-015306-us58wwmp 1281 4 group group NN cord-015306-us58wwmp 1281 5 . . . cord-015306-us58wwmp 1282 1 Results result NNS cord-015306-us58wwmp 1282 2 : : : cord-015306-us58wwmp 1283 1 The the DT cord-015306-us58wwmp 1283 2 level level NN cord-015306-us58wwmp 1283 3 of of IN cord-015306-us58wwmp 1283 4 TGF TGF NNP cord-015306-us58wwmp 1283 5 - - HYPH cord-015306-us58wwmp 1283 6 β1 β1 NNP cord-015306-us58wwmp 1283 7 and and CC cord-015306-us58wwmp 1283 8 MMP-9 MMP-9 NNP cord-015306-us58wwmp 1283 9 inserum inserum NNP cord-015306-us58wwmp 1283 10 and and CC cord-015306-us58wwmp 1283 11 urinary urinary NN cord-015306-us58wwmp 1283 12 of of IN cord-015306-us58wwmp 1283 13 the the DT cord-015306-us58wwmp 1283 14 IgAN IgAN NNP cord-015306-us58wwmp 1283 15 group group NN cord-015306-us58wwmp 1283 16 was be VBD cord-015306-us58wwmp 1283 17 significantly significantly RB cord-015306-us58wwmp 1283 18 higher high JJR cord-015306-us58wwmp 1283 19 than than IN cord-015306-us58wwmp 1283 20 that that DT cord-015306-us58wwmp 1283 21 in in IN cord-015306-us58wwmp 1283 22 the the DT cord-015306-us58wwmp 1283 23 control control NN cord-015306-us58wwmp 1283 24 group group NN cord-015306-us58wwmp 1283 25 ( ( -LRB- cord-015306-us58wwmp 1283 26 P<0.05 P<0.05 NNP cord-015306-us58wwmp 1283 27 ) ) -RRB- cord-015306-us58wwmp 1283 28 . . . cord-015306-us58wwmp 1284 1 Both both DT cord-015306-us58wwmp 1284 2 the the DT cord-015306-us58wwmp 1284 3 level level NN cord-015306-us58wwmp 1284 4 of of IN cord-015306-us58wwmp 1284 5 TGF TGF NNP cord-015306-us58wwmp 1284 6 - - HYPH cord-015306-us58wwmp 1284 7 β1 β1 NNP cord-015306-us58wwmp 1284 8 and and CC cord-015306-us58wwmp 1284 9 MMP-9 MMP-9 NNP cord-015306-us58wwmp 1284 10 inserum inserum NNP cord-015306-us58wwmp 1284 11 and and CC cord-015306-us58wwmp 1284 12 urinary urinary NN cord-015306-us58wwmp 1284 13 of of IN cord-015306-us58wwmp 1284 14 the the DT cord-015306-us58wwmp 1284 15 three three CD cord-015306-us58wwmp 1284 16 clinical clinical JJ cord-015306-us58wwmp 1284 17 groups group NNS cord-015306-us58wwmp 1284 18 in in IN cord-015306-us58wwmp 1284 19 the the DT cord-015306-us58wwmp 1284 20 IgAN IgAN NNP cord-015306-us58wwmp 1284 21 children child NNS cord-015306-us58wwmp 1284 22 were be VBD cord-015306-us58wwmp 1284 23 not not RB cord-015306-us58wwmp 1284 24 statistically statistically RB cord-015306-us58wwmp 1284 25 different different JJ cord-015306-us58wwmp 1284 26 . . . cord-015306-us58wwmp 1285 1 The the DT cord-015306-us58wwmp 1285 2 serum serum NN cord-015306-us58wwmp 1285 3 TGF TGF NNP cord-015306-us58wwmp 1285 4 - - HYPH cord-015306-us58wwmp 1285 5 β1 β1 NNP cord-015306-us58wwmp 1285 6 and and CC cord-015306-us58wwmp 1285 7 MMP-9 MMP-9 NNP cord-015306-us58wwmp 1285 8 levels level NNS cord-015306-us58wwmp 1285 9 were be VBD cord-015306-us58wwmp 1285 10 significantly significantly RB cord-015306-us58wwmp 1285 11 higher high JJR cord-015306-us58wwmp 1285 12 in in IN cord-015306-us58wwmp 1285 13 Lee Lee NNP cord-015306-us58wwmp 1285 14 ' ' POS cord-015306-us58wwmp 1285 15 s s POS cord-015306-us58wwmp 1285 16 III+ III+ NNP cord-015306-us58wwmp 1285 17 IV IV NNP cord-015306-us58wwmp 1285 18 group group NN cord-015306-us58wwmp 1285 19 compared compare VBN cord-015306-us58wwmp 1285 20 to to IN cord-015306-us58wwmp 1285 21 that that DT cord-015306-us58wwmp 1285 22 in in IN cord-015306-us58wwmp 1285 23 Lee Lee NNP cord-015306-us58wwmp 1285 24 's 's POS cord-015306-us58wwmp 1285 25 I+II I+II NNP cord-015306-us58wwmp 1285 26 group(P<0.05 group(P<0.05 NNP cord-015306-us58wwmp 1285 27 ) ) -RRB- cord-015306-us58wwmp 1285 28 . . . cord-015306-us58wwmp 1286 1 The the DT cord-015306-us58wwmp 1286 2 difference difference NN cord-015306-us58wwmp 1286 3 was be VBD cord-015306-us58wwmp 1286 4 not not RB cord-015306-us58wwmp 1286 5 statistically statistically RB cord-015306-us58wwmp 1286 6 significant significant JJ cord-015306-us58wwmp 1286 7 between between IN cord-015306-us58wwmp 1286 8 urinary urinary JJ cord-015306-us58wwmp 1286 9 TGF TGF NNP cord-015306-us58wwmp 1286 10 - - HYPH cord-015306-us58wwmp 1286 11 β1 β1 NNP cord-015306-us58wwmp 1286 12 and and CC cord-015306-us58wwmp 1286 13 MMP-9 MMP-9 NNP cord-015306-us58wwmp 1286 14 levels level NNS cord-015306-us58wwmp 1286 15 in in IN cord-015306-us58wwmp 1286 16 the the DT cord-015306-us58wwmp 1286 17 two two CD cord-015306-us58wwmp 1286 18 Lee Lee NNP cord-015306-us58wwmp 1286 19 's 's POS cord-015306-us58wwmp 1286 20 group group NN cord-015306-us58wwmp 1286 21 . . . cord-015306-us58wwmp 1287 1 The the DT cord-015306-us58wwmp 1287 2 serum serum NN cord-015306-us58wwmp 1287 3 TGF TGF NNP cord-015306-us58wwmp 1287 4 - - HYPH cord-015306-us58wwmp 1287 5 β1 β1 NNP cord-015306-us58wwmp 1287 6 and and CC cord-015306-us58wwmp 1287 7 MMP-9 MMP-9 NNP cord-015306-us58wwmp 1287 8 levels level NNS cord-015306-us58wwmp 1287 9 of of IN cord-015306-us58wwmp 1287 10 renal renal JJ cord-015306-us58wwmp 1287 11 failure failure NN cord-015306-us58wwmp 1287 12 group group NN cord-015306-us58wwmp 1287 13 were be VBD cord-015306-us58wwmp 1287 14 significantly significantly RB cord-015306-us58wwmp 1287 15 higher high JJR cord-015306-us58wwmp 1287 16 than than IN cord-015306-us58wwmp 1287 17 that that DT cord-015306-us58wwmp 1287 18 of of IN cord-015306-us58wwmp 1287 19 normal normal JJ cord-015306-us58wwmp 1287 20 renal renal JJ cord-015306-us58wwmp 1287 21 function function NN cord-015306-us58wwmp 1287 22 group group NN cord-015306-us58wwmp 1287 23 in in IN cord-015306-us58wwmp 1287 24 IgAN IgAN NNP cord-015306-us58wwmp 1287 25 children(P<0.05),and children(P<0.05),and NNP cord-015306-us58wwmp 1288 1 the the DT cord-015306-us58wwmp 1288 2 urinary urinary JJ cord-015306-us58wwmp 1288 3 TGF TGF NNP cord-015306-us58wwmp 1288 4 - - HYPH cord-015306-us58wwmp 1288 5 β1 β1 NNP cord-015306-us58wwmp 1288 6 and and CC cord-015306-us58wwmp 1288 7 MMP-9 MMP-9 NNP cord-015306-us58wwmp 1288 8 levels level NNS cord-015306-us58wwmp 1288 9 of of IN cord-015306-us58wwmp 1288 10 the the DT cord-015306-us58wwmp 1288 11 two two CD cord-015306-us58wwmp 1288 12 group group NN cord-015306-us58wwmp 1288 13 were be VBD cord-015306-us58wwmp 1288 14 not not RB cord-015306-us58wwmp 1288 15 statistically statistically RB cord-015306-us58wwmp 1288 16 significant significant JJ cord-015306-us58wwmp 1288 17 different different JJ cord-015306-us58wwmp 1288 18 . . . cord-015306-us58wwmp 1289 1 The the DT cord-015306-us58wwmp 1289 2 serum serum NN cord-015306-us58wwmp 1289 3 and and CC cord-015306-us58wwmp 1289 4 urinary urinary JJ cord-015306-us58wwmp 1289 5 TGF TGF NNP cord-015306-us58wwmp 1289 6 - - HYPH cord-015306-us58wwmp 1289 7 β1 β1 NNP cord-015306-us58wwmp 1289 8 and and CC cord-015306-us58wwmp 1289 9 MMP-9 MMP-9 NNP cord-015306-us58wwmp 1289 10 levels level NNS cord-015306-us58wwmp 1289 11 were be VBD cord-015306-us58wwmp 1289 12 not not RB cord-015306-us58wwmp 1289 13 statistically statistically RB cord-015306-us58wwmp 1289 14 different different JJ cord-015306-us58wwmp 1289 15 in in IN cord-015306-us58wwmp 1289 16 all all DT cord-015306-us58wwmp 1289 17 immune immune JJ cord-015306-us58wwmp 1289 18 classification classification NN cord-015306-us58wwmp 1289 19 . . . cord-015306-us58wwmp 1290 1 Conclusion conclusion NN cord-015306-us58wwmp 1290 2 : : : cord-015306-us58wwmp 1291 1 The the DT cord-015306-us58wwmp 1291 2 serum serum NN cord-015306-us58wwmp 1291 3 TGF TGF NNP cord-015306-us58wwmp 1291 4 - - HYPH cord-015306-us58wwmp 1291 5 β1 β1 NNP cord-015306-us58wwmp 1291 6 and and CC cord-015306-us58wwmp 1291 7 MMP-9 MMP-9 NNP cord-015306-us58wwmp 1291 8 plays play VBZ cord-015306-us58wwmp 1291 9 an an DT cord-015306-us58wwmp 1291 10 important important JJ cord-015306-us58wwmp 1291 11 role role NN cord-015306-us58wwmp 1291 12 in in IN cord-015306-us58wwmp 1291 13 the the DT cord-015306-us58wwmp 1291 14 severity severity NN cord-015306-us58wwmp 1291 15 and and CC cord-015306-us58wwmp 1291 16 progression progression NN cord-015306-us58wwmp 1291 17 of of IN cord-015306-us58wwmp 1291 18 children child NNS cord-015306-us58wwmp 1291 19 with with IN cord-015306-us58wwmp 1291 20 IgAN IgAN NNP cord-015306-us58wwmp 1291 21 . . . cord-015306-us58wwmp 1292 1 TGF TGF NNP cord-015306-us58wwmp 1292 2 - - HYPH cord-015306-us58wwmp 1292 3 β1 β1 NNP cord-015306-us58wwmp 1292 4 and and CC cord-015306-us58wwmp 1292 5 MMP-9 MMP-9 NNP cord-015306-us58wwmp 1292 6 may may MD cord-015306-us58wwmp 1292 7 be be VB cord-015306-us58wwmp 1292 8 two two CD cord-015306-us58wwmp 1292 9 more more RBR cord-015306-us58wwmp 1292 10 noninvasive noninvasive JJ cord-015306-us58wwmp 1292 11 and and CC cord-015306-us58wwmp 1292 12 easy easy JJ cord-015306-us58wwmp 1292 13 repeatable repeatable JJ cord-015306-us58wwmp 1292 14 biomarkers biomarker NNS cord-015306-us58wwmp 1292 15 to to TO cord-015306-us58wwmp 1292 16 be be VB cord-015306-us58wwmp 1292 17 used use VBN cord-015306-us58wwmp 1292 18 in in IN cord-015306-us58wwmp 1292 19 evaluating evaluate VBG cord-015306-us58wwmp 1292 20 the the DT cord-015306-us58wwmp 1292 21 progression progression NN cord-015306-us58wwmp 1292 22 of of IN cord-015306-us58wwmp 1292 23 IgAN IgAN NNP cord-015306-us58wwmp 1292 24 in in IN cord-015306-us58wwmp 1292 25 children child NNS cord-015306-us58wwmp 1292 26 . . . cord-015306-us58wwmp 1293 1 Abstract abstract JJ cord-015306-us58wwmp 1293 2 # # NN cord-015306-us58wwmp 1294 1 P p NN cord-015306-us58wwmp 1294 2 - - HYPH cord-015306-us58wwmp 1294 3 SAT163 SAT163 NNP cord-015306-us58wwmp 1294 4 Glomerular Glomerular NNP cord-015306-us58wwmp 1294 5 ACE2 ACE2 NNP cord-015306-us58wwmp 1294 6 expression expression NN cord-015306-us58wwmp 1294 7 is be VBZ cord-015306-us58wwmp 1294 8 enhanced enhance VBN cord-015306-us58wwmp 1294 9 in in IN cord-015306-us58wwmp 1294 10 pediatric pediatric JJ cord-015306-us58wwmp 1294 11 IgA IgA NNP cord-015306-us58wwmp 1294 12 nephropathy nephropathy NN cord-015306-us58wwmp 1294 13 Yusuke Yusuke NNP cord-015306-us58wwmp 1294 14 Seki Seki NNP cord-015306-us58wwmp 1294 15 , , , cord-015306-us58wwmp 1294 16 Maki Maki NNP cord-015306-us58wwmp 1294 17 Urushihara Urushihara NNP cord-015306-us58wwmp 1294 18 , , , cord-015306-us58wwmp 1294 19 Takahiro Takahiro NNP cord-015306-us58wwmp 1294 20 Tayama Tayama NNP cord-015306-us58wwmp 1294 21 , , , cord-015306-us58wwmp 1294 22 Takashi Takashi NNP cord-015306-us58wwmp 1294 23 Nagai Nagai NNP cord-015306-us58wwmp 1294 24 , , , cord-015306-us58wwmp 1294 25 Ariunbold Ariunbold NNP cord-015306-us58wwmp 1294 26 Jamba Jamba NNP cord-015306-us58wwmp 1294 27 , , , cord-015306-us58wwmp 1294 28 Shuji Shuji NNP cord-015306-us58wwmp 1294 29 Kondo Kondo NNP cord-015306-us58wwmp 1294 30 , , , cord-015306-us58wwmp 1294 31 Shoji Shoji NNP cord-015306-us58wwmp 1294 32 Kagami Kagami NNP cord-015306-us58wwmp 1294 33 Department Department NNP cord-015306-us58wwmp 1294 34 of of IN cord-015306-us58wwmp 1294 35 Pediatrics Pediatrics NNP cord-015306-us58wwmp 1294 36 , , , cord-015306-us58wwmp 1295 1 The the DT cord-015306-us58wwmp 1295 2 University University NNP cord-015306-us58wwmp 1295 3 of of IN cord-015306-us58wwmp 1295 4 Tokushima Tokushima NNP cord-015306-us58wwmp 1295 5 Graduate Graduate NNP cord-015306-us58wwmp 1295 6 School School NNP cord-015306-us58wwmp 1295 7 , , , cord-015306-us58wwmp 1295 8 Tokushima Tokushima NNP cord-015306-us58wwmp 1295 9 , , , cord-015306-us58wwmp 1296 1 Japan Japan NNP cord-015306-us58wwmp 1296 2 Objective Objective NNP cord-015306-us58wwmp 1296 3 : : : cord-015306-us58wwmp 1297 1 Angiotensin angiotensin NN cord-015306-us58wwmp 1297 2 converting convert VBG cord-015306-us58wwmp 1297 3 enzyme enzyme NN cord-015306-us58wwmp 1298 1 ( ( -LRB- cord-015306-us58wwmp 1298 2 ACE)2 ace)2 NN cord-015306-us58wwmp 1298 3 is be VBZ cord-015306-us58wwmp 1298 4 a a DT cord-015306-us58wwmp 1298 5 homolog homolog NN cord-015306-us58wwmp 1298 6 of of IN cord-015306-us58wwmp 1298 7 ACE ace NN cord-015306-us58wwmp 1298 8 and and CC cord-015306-us58wwmp 1298 9 is be VBZ cord-015306-us58wwmp 1298 10 thought think VBN cord-015306-us58wwmp 1298 11 to to TO cord-015306-us58wwmp 1298 12 be be VB cord-015306-us58wwmp 1298 13 a a DT cord-015306-us58wwmp 1298 14 potent potent JJ cord-015306-us58wwmp 1298 15 counter counter NN cord-015306-us58wwmp 1298 16 - - NN cord-015306-us58wwmp 1298 17 regulator regulator NN cord-015306-us58wwmp 1298 18 against against IN cord-015306-us58wwmp 1298 19 ACE ace NN cord-015306-us58wwmp 1298 20 activity activity NN cord-015306-us58wwmp 1298 21 . . . cord-015306-us58wwmp 1299 1 While while IN cord-015306-us58wwmp 1299 2 renin renin NN cord-015306-us58wwmp 1299 3 - - HYPH cord-015306-us58wwmp 1299 4 angiotensin angiotensin NN cord-015306-us58wwmp 1299 5 system system NN cord-015306-us58wwmp 1299 6 ( ( -LRB- cord-015306-us58wwmp 1299 7 RAS RAS NNP cord-015306-us58wwmp 1299 8 ) ) -RRB- cord-015306-us58wwmp 1299 9 plays play VBZ cord-015306-us58wwmp 1299 10 a a DT cord-015306-us58wwmp 1299 11 critical critical JJ cord-015306-us58wwmp 1299 12 role role NN cord-015306-us58wwmp 1299 13 in in IN cord-015306-us58wwmp 1299 14 the the DT cord-015306-us58wwmp 1299 15 progression progression NN cord-015306-us58wwmp 1299 16 of of IN cord-015306-us58wwmp 1299 17 IgA IgA NNP cord-015306-us58wwmp 1299 18 nephropathy nephropathy NNP cord-015306-us58wwmp 1299 19 ( ( -LRB- cord-015306-us58wwmp 1299 20 IgAN IgAN NNP cord-015306-us58wwmp 1299 21 ) ) -RRB- cord-015306-us58wwmp 1299 22 , , , cord-015306-us58wwmp 1299 23 the the DT cord-015306-us58wwmp 1299 24 role role NN cord-015306-us58wwmp 1299 25 of of IN cord-015306-us58wwmp 1299 26 ACE2 ACE2 NNP cord-015306-us58wwmp 1299 27 has have VBZ cord-015306-us58wwmp 1299 28 not not RB cord-015306-us58wwmp 1299 29 been be VBN cord-015306-us58wwmp 1299 30 investigated investigate VBN cord-015306-us58wwmp 1299 31 in in IN cord-015306-us58wwmp 1299 32 pediatric pediatric JJ cord-015306-us58wwmp 1299 33 patients patient NNS cord-015306-us58wwmp 1299 34 with with IN cord-015306-us58wwmp 1299 35 IgAN IgAN NNP cord-015306-us58wwmp 1299 36 . . . cord-015306-us58wwmp 1300 1 This this DT cord-015306-us58wwmp 1300 2 study study NN cord-015306-us58wwmp 1300 3 was be VBD cord-015306-us58wwmp 1300 4 performed perform VBN cord-015306-us58wwmp 1300 5 to to TO cord-015306-us58wwmp 1300 6 examine examine VB cord-015306-us58wwmp 1300 7 the the DT cord-015306-us58wwmp 1300 8 relationship relationship NN cord-015306-us58wwmp 1300 9 between between IN cord-015306-us58wwmp 1300 10 ACE2 ACE2 NNP cord-015306-us58wwmp 1300 11 expression expression NN cord-015306-us58wwmp 1300 12 and and CC cord-015306-us58wwmp 1300 13 the the DT cord-015306-us58wwmp 1300 14 development development NN cord-015306-us58wwmp 1300 15 of of IN cord-015306-us58wwmp 1300 16 pediatric pediatric JJ cord-015306-us58wwmp 1300 17 IgAN IgAN NNP cord-015306-us58wwmp 1300 18 . . . cord-015306-us58wwmp 1301 1 Methods method NNS cord-015306-us58wwmp 1301 2 : : : cord-015306-us58wwmp 1302 1 We -PRON- PRP cord-015306-us58wwmp 1302 2 performed perform VBD cord-015306-us58wwmp 1302 3 immunohistochemical immunohistochemical JJ cord-015306-us58wwmp 1302 4 analysis analysis NN cord-015306-us58wwmp 1302 5 of of IN cord-015306-us58wwmp 1302 6 ACE2 ACE2 NNP cord-015306-us58wwmp 1302 7 and and CC cord-015306-us58wwmp 1302 8 ACE ACE NNP cord-015306-us58wwmp 1302 9 in in IN cord-015306-us58wwmp 1302 10 kidney kidney NN cord-015306-us58wwmp 1302 11 tissues tissue NNS cord-015306-us58wwmp 1302 12 from from IN cord-015306-us58wwmp 1302 13 39 39 CD cord-015306-us58wwmp 1302 14 patients patient NNS cord-015306-us58wwmp 1302 15 with with IN cord-015306-us58wwmp 1302 16 pediatric pediatric JJ cord-015306-us58wwmp 1302 17 IgAN IgAN NNP cord-015306-us58wwmp 1302 18 and and CC cord-015306-us58wwmp 1302 19 14 14 CD cord-015306-us58wwmp 1302 20 patients patient NNS cord-015306-us58wwmp 1302 21 with with IN cord-015306-us58wwmp 1302 22 minor minor JJ cord-015306-us58wwmp 1302 23 glomerular glomerular JJ cord-015306-us58wwmp 1302 24 abnormalities abnormality NNS cord-015306-us58wwmp 1302 25 ( ( -LRB- cord-015306-us58wwmp 1302 26 MGA MGA NNP cord-015306-us58wwmp 1302 27 ) ) -RRB- cord-015306-us58wwmp 1302 28 using use VBG cord-015306-us58wwmp 1302 29 specific specific JJ cord-015306-us58wwmp 1302 30 antibodies antibody NNS cord-015306-us58wwmp 1302 31 and and CC cord-015306-us58wwmp 1302 32 examined examine VBD cord-015306-us58wwmp 1302 33 the the DT cord-015306-us58wwmp 1302 34 correlation correlation NN cord-015306-us58wwmp 1302 35 with with IN cord-015306-us58wwmp 1302 36 clinical clinical JJ cord-015306-us58wwmp 1302 37 parameters parameter NNS cord-015306-us58wwmp 1302 38 and and CC cord-015306-us58wwmp 1302 39 pathological pathological JJ cord-015306-us58wwmp 1302 40 findings finding NNS cord-015306-us58wwmp 1302 41 . . . cord-015306-us58wwmp 1303 1 In in IN cord-015306-us58wwmp 1303 2 addition addition NN cord-015306-us58wwmp 1303 3 , , , cord-015306-us58wwmp 1303 4 we -PRON- PRP cord-015306-us58wwmp 1303 5 elucidated elucidate VBD cord-015306-us58wwmp 1303 6 the the DT cord-015306-us58wwmp 1303 7 effects effect NNS cord-015306-us58wwmp 1303 8 of of IN cord-015306-us58wwmp 1303 9 various various JJ cord-015306-us58wwmp 1303 10 cytokines cytokine NNS cord-015306-us58wwmp 1303 11 on on IN cord-015306-us58wwmp 1303 12 ACE2 ACE2 NNP cord-015306-us58wwmp 1303 13 expression expression NN cord-015306-us58wwmp 1303 14 in in IN cord-015306-us58wwmp 1303 15 cultured cultured JJ cord-015306-us58wwmp 1303 16 human human JJ cord-015306-us58wwmp 1303 17 mesangial mesangial JJ cord-015306-us58wwmp 1303 18 cells cell NNS cord-015306-us58wwmp 1303 19 ( ( -LRB- cord-015306-us58wwmp 1303 20 MCs MCs NNP cord-015306-us58wwmp 1303 21 ) ) -RRB- cord-015306-us58wwmp 1303 22 by by IN cord-015306-us58wwmp 1303 23 quantitative quantitative JJ cord-015306-us58wwmp 1303 24 real real JJ cord-015306-us58wwmp 1303 25 time time NN cord-015306-us58wwmp 1303 26 PCR PCR NNP cord-015306-us58wwmp 1303 27 and and CC cord-015306-us58wwmp 1303 28 western western JJ cord-015306-us58wwmp 1303 29 blot blot NN cord-015306-us58wwmp 1303 30 analyses analysis NNS cord-015306-us58wwmp 1303 31 . . . cord-015306-us58wwmp 1304 1 Results result NNS cord-015306-us58wwmp 1304 2 : : : cord-015306-us58wwmp 1305 1 ACE2 ace2 JJ cord-015306-us58wwmp 1305 2 expression expression NN cord-015306-us58wwmp 1305 3 levels level NNS cord-015306-us58wwmp 1305 4 in in IN cord-015306-us58wwmp 1305 5 glomeruli glomerulus NNS cord-015306-us58wwmp 1305 6 ( ( -LRB- cord-015306-us58wwmp 1305 7 r r NN cord-015306-us58wwmp 1305 8 = = SYM cord-015306-us58wwmp 1305 9 0.5732 0.5732 CD cord-015306-us58wwmp 1305 10 , , , cord-015306-us58wwmp 1305 11 P p NN cord-015306-us58wwmp 1305 12 < < XX cord-015306-us58wwmp 1305 13 0.0001 0.0001 CD cord-015306-us58wwmp 1305 14 ) ) -RRB- cord-015306-us58wwmp 1305 15 and and CC cord-015306-us58wwmp 1305 16 tubules tubule NNS cord-015306-us58wwmp 1305 17 ( ( -LRB- cord-015306-us58wwmp 1305 18 r r NN cord-015306-us58wwmp 1305 19 = = SYM cord-015306-us58wwmp 1305 20 0.4917 0.4917 CD cord-015306-us58wwmp 1305 21 , , , cord-015306-us58wwmp 1305 22 P p NN cord-015306-us58wwmp 1305 23 = = SYM cord-015306-us58wwmp 1305 24 0.0002 0.0002 CD cord-015306-us58wwmp 1305 25 ) ) -RRB- cord-015306-us58wwmp 1305 26 were be VBD cord-015306-us58wwmp 1305 27 positively positively RB cord-015306-us58wwmp 1305 28 correlated correlate VBN cord-015306-us58wwmp 1305 29 with with IN cord-015306-us58wwmp 1305 30 the the DT cord-015306-us58wwmp 1305 31 mesangial mesangial JJ cord-015306-us58wwmp 1305 32 hypercellularity hypercellularity NNP cord-015306-us58wwmp 1305 33 score score NN cord-015306-us58wwmp 1305 34 , , , cord-015306-us58wwmp 1305 35 while while IN cord-015306-us58wwmp 1305 36 ACE ace NN cord-015306-us58wwmp 1305 37 expression expression NN cord-015306-us58wwmp 1305 38 levels level NNS cord-015306-us58wwmp 1305 39 in in IN cord-015306-us58wwmp 1305 40 glomeruli glomerulus NNS cord-015306-us58wwmp 1305 41 ( ( -LRB- cord-015306-us58wwmp 1305 42 r r NN cord-015306-us58wwmp 1305 43 = = NFP cord-015306-us58wwmp 1306 1 0.1331 0.1331 CD cord-015306-us58wwmp 1306 2 , , , cord-015306-us58wwmp 1306 3 P p NN cord-015306-us58wwmp 1306 4 = = SYM cord-015306-us58wwmp 1306 5 0.3420 0.3420 CD cord-015306-us58wwmp 1306 6 ) ) -RRB- cord-015306-us58wwmp 1306 7 and and CC cord-015306-us58wwmp 1306 8 tubules tubule NNS cord-015306-us58wwmp 1306 9 ( ( -LRB- cord-015306-us58wwmp 1306 10 r r NN cord-015306-us58wwmp 1306 11 = = SYM cord-015306-us58wwmp 1306 12 0.0743 0.0743 CD cord-015306-us58wwmp 1306 13 , , . cord-015306-us58wwmp 1307 1 P p NN cord-015306-us58wwmp 1307 2 < < XX cord-015306-us58wwmp 1307 3 0.5959 0.5959 CD cord-015306-us58wwmp 1307 4 ) ) -RRB- cord-015306-us58wwmp 1307 5 are be VBP cord-015306-us58wwmp 1307 6 not not RB cord-015306-us58wwmp 1307 7 . . . cord-015306-us58wwmp 1308 1 Multiple multiple JJ cord-015306-us58wwmp 1308 2 regression regression NN cord-015306-us58wwmp 1308 3 analysis analysis NN cord-015306-us58wwmp 1308 4 showed show VBD cord-015306-us58wwmp 1308 5 that that IN cord-015306-us58wwmp 1308 6 the the DT cord-015306-us58wwmp 1308 7 mesangial mesangial JJ cord-015306-us58wwmp 1308 8 hypercellularity hypercellularity NNP cord-015306-us58wwmp 1308 9 score score NN cord-015306-us58wwmp 1308 10 correlated correlate VBN cord-015306-us58wwmp 1308 11 with with IN cord-015306-us58wwmp 1308 12 ACE2 ACE2 NNP cord-015306-us58wwmp 1308 13 expression expression NN cord-015306-us58wwmp 1308 14 level level NN cord-015306-us58wwmp 1308 15 in in IN cord-015306-us58wwmp 1308 16 glomeruli glomerulus NNS cord-015306-us58wwmp 1308 17 and and CC cord-015306-us58wwmp 1308 18 urinary urinary JJ cord-015306-us58wwmp 1308 19 protein protein NN cord-015306-us58wwmp 1308 20 - - HYPH cord-015306-us58wwmp 1308 21 creatinine creatinine NN cord-015306-us58wwmp 1308 22 ratio ratio NN cord-015306-us58wwmp 1308 23 ( ( -LRB- cord-015306-us58wwmp 1308 24 r r NN cord-015306-us58wwmp 1308 25 = = NN cord-015306-us58wwmp 1308 26 0.6295 0.6295 CD cord-015306-us58wwmp 1308 27 , , , cord-015306-us58wwmp 1308 28 P p NN cord-015306-us58wwmp 1308 29 < < XX cord-015306-us58wwmp 1308 30 0.0001 0.0001 CD cord-015306-us58wwmp 1308 31 ) ) -RRB- cord-015306-us58wwmp 1308 32 . . . cord-015306-us58wwmp 1309 1 In in IN cord-015306-us58wwmp 1309 2 IgAN igan JJ cord-015306-us58wwmp 1309 3 patients patient NNS cord-015306-us58wwmp 1309 4 not not RB cord-015306-us58wwmp 1309 5 treated treat VBN cord-015306-us58wwmp 1309 6 with with IN cord-015306-us58wwmp 1309 7 a a DT cord-015306-us58wwmp 1309 8 RAS RAS NNP cord-015306-us58wwmp 1309 9 blocker blocker NN cord-015306-us58wwmp 1309 10 ( ( -LRB- cord-015306-us58wwmp 1309 11 ACE ace NN cord-015306-us58wwmp 1309 12 inhibitors inhibitor NNS cord-015306-us58wwmp 1309 13 or or CC cord-015306-us58wwmp 1309 14 angiotensin angiotensin NN cord-015306-us58wwmp 1309 15 II II NNP cord-015306-us58wwmp 1309 16 type type NN cord-015306-us58wwmp 1309 17 1 1 CD cord-015306-us58wwmp 1309 18 receptor receptor NN cord-015306-us58wwmp 1309 19 blockers blocker NNS cord-015306-us58wwmp 1309 20 ) ) -RRB- cord-015306-us58wwmp 1309 21 , , , cord-015306-us58wwmp 1310 1 ACE2 ace2 JJ cord-015306-us58wwmp 1310 2 expression expression NN cord-015306-us58wwmp 1310 3 levels level NNS cord-015306-us58wwmp 1310 4 in in IN cord-015306-us58wwmp 1310 5 glomeruli glomerulus NNS cord-015306-us58wwmp 1310 6 were be VBD cord-015306-us58wwmp 1310 7 significantly significantly RB cord-015306-us58wwmp 1310 8 increased increase VBN cord-015306-us58wwmp 1310 9 compared compare VBN cord-015306-us58wwmp 1310 10 to to IN cord-015306-us58wwmp 1310 11 patients patient NNS cord-015306-us58wwmp 1310 12 with with IN cord-015306-us58wwmp 1310 13 MGA MGA NNP cord-015306-us58wwmp 1310 14 ( ( -LRB- cord-015306-us58wwmp 1310 15 P p NN cord-015306-us58wwmp 1310 16 < < XX cord-015306-us58wwmp 1310 17 0.0001 0.0001 CD cord-015306-us58wwmp 1310 18 ) ) -RRB- cord-015306-us58wwmp 1310 19 . . . cord-015306-us58wwmp 1311 1 IgA IgA NNP cord-015306-us58wwmp 1311 2 patients patient NNS cord-015306-us58wwmp 1311 3 treated treat VBN cord-015306-us58wwmp 1311 4 with with IN cord-015306-us58wwmp 1311 5 a a DT cord-015306-us58wwmp 1311 6 RAS RAS NNP cord-015306-us58wwmp 1311 7 blocker blocker NN cord-015306-us58wwmp 1311 8 did do VBD cord-015306-us58wwmp 1311 9 not not RB cord-015306-us58wwmp 1311 10 show show VB cord-015306-us58wwmp 1311 11 this this DT cord-015306-us58wwmp 1311 12 increase increase NN cord-015306-us58wwmp 1311 13 in in IN cord-015306-us58wwmp 1311 14 ACE2 ACE2 NNP cord-015306-us58wwmp 1311 15 exrepssion exrepssion NN cord-015306-us58wwmp 1311 16 . . . cord-015306-us58wwmp 1312 1 Furthermore furthermore RB cord-015306-us58wwmp 1312 2 , , , cord-015306-us58wwmp 1312 3 ACE2 ACE2 NNP cord-015306-us58wwmp 1312 4 mRNA mRNA NNP cord-015306-us58wwmp 1312 5 and and CC cord-015306-us58wwmp 1312 6 protein protein NN cord-015306-us58wwmp 1312 7 expression expression NN cord-015306-us58wwmp 1312 8 was be VBD cord-015306-us58wwmp 1312 9 enhanced enhance VBN cord-015306-us58wwmp 1312 10 by by IN cord-015306-us58wwmp 1312 11 interleukin-1 interleukin-1 NNP cord-015306-us58wwmp 1312 12 beta beta NN cord-015306-us58wwmp 1312 13 , , , cord-015306-us58wwmp 1312 14 a a DT cord-015306-us58wwmp 1312 15 pro pro JJ cord-015306-us58wwmp 1312 16 - - JJ cord-015306-us58wwmp 1312 17 inlammatory inlammatory JJ cord-015306-us58wwmp 1312 18 cytokine cytokine NN cord-015306-us58wwmp 1312 19 , , , cord-015306-us58wwmp 1312 20 and and CC cord-015306-us58wwmp 1312 21 suppressed suppress VBN cord-015306-us58wwmp 1312 22 by by IN cord-015306-us58wwmp 1312 23 transforming transform VBG cord-015306-us58wwmp 1312 24 growth growth NN cord-015306-us58wwmp 1312 25 factor factor NN cord-015306-us58wwmp 1312 26 - - HYPH cord-015306-us58wwmp 1312 27 beta beta NN cord-015306-us58wwmp 1312 28 1 1 CD cord-015306-us58wwmp 1312 29 , , , cord-015306-us58wwmp 1312 30 a a DT cord-015306-us58wwmp 1312 31 pro pro JJ cord-015306-us58wwmp 1312 32 - - JJ cord-015306-us58wwmp 1312 33 fibotic fibotic JJ cord-015306-us58wwmp 1312 34 factor factor NN cord-015306-us58wwmp 1312 35 in in IN cord-015306-us58wwmp 1312 36 the the DT cord-015306-us58wwmp 1312 37 progression progression NN cord-015306-us58wwmp 1312 38 of of IN cord-015306-us58wwmp 1312 39 IgAN IgAN NNP cord-015306-us58wwmp 1312 40 . . . cord-015306-us58wwmp 1313 1 Conclusion conclusion NN cord-015306-us58wwmp 1313 2 : : : cord-015306-us58wwmp 1314 1 These these DT cord-015306-us58wwmp 1314 2 data datum NNS cord-015306-us58wwmp 1314 3 indicate indicate VBP cord-015306-us58wwmp 1314 4 that that IN cord-015306-us58wwmp 1314 5 ACE2 ACE2 NNP cord-015306-us58wwmp 1314 6 expression expression NN cord-015306-us58wwmp 1314 7 in in IN cord-015306-us58wwmp 1314 8 glomeruli glomerulus NNS cord-015306-us58wwmp 1314 9 is be VBZ cord-015306-us58wwmp 1314 10 associated associate VBN cord-015306-us58wwmp 1314 11 with with IN cord-015306-us58wwmp 1314 12 mesangial mesangial JJ cord-015306-us58wwmp 1314 13 hypercellularity hypercellularity NN cord-015306-us58wwmp 1314 14 in in IN cord-015306-us58wwmp 1314 15 the the DT cord-015306-us58wwmp 1314 16 active active JJ cord-015306-us58wwmp 1314 17 phase phase NN cord-015306-us58wwmp 1314 18 of of IN cord-015306-us58wwmp 1314 19 pediatric pediatric JJ cord-015306-us58wwmp 1314 20 IgAN IgAN NNP cord-015306-us58wwmp 1314 21 . . . cord-015306-us58wwmp 1315 1 Abstract abstract JJ cord-015306-us58wwmp 1315 2 # # NN cord-015306-us58wwmp 1315 3 P p NN cord-015306-us58wwmp 1315 4 - - HYPH cord-015306-us58wwmp 1315 5 SAT164 sat164 JJ cord-015306-us58wwmp 1315 6 Increased increase VBN cord-015306-us58wwmp 1315 7 serum serum NN cord-015306-us58wwmp 1315 8 interleukin-17 interleukin-17 NN cord-015306-us58wwmp 1315 9 and and CC cord-015306-us58wwmp 1315 10 peripheral peripheral JJ cord-015306-us58wwmp 1315 11 Th17 Th17 NNP cord-015306-us58wwmp 1315 12 cells cell NNS cord-015306-us58wwmp 1315 13 in in IN cord-015306-us58wwmp 1315 14 children child NNS cord-015306-us58wwmp 1315 15 with with IN cord-015306-us58wwmp 1315 16 Henoch Henoch NNP cord-015306-us58wwmp 1315 17 - - HYPH cord-015306-us58wwmp 1315 18 Schonlein Schonlein NNP cord-015306-us58wwmp 1315 19 purpura purpura NN cord-015306-us58wwmp 1315 20 nephrology nephrology NN cord-015306-us58wwmp 1315 21 ( ( -LRB- cord-015306-us58wwmp 1315 22 HSPN HSPN NNP cord-015306-us58wwmp 1315 23 ) ) -RRB- cord-015306-us58wwmp 1316 1 xiaoshan xiaoshan NNP cord-015306-us58wwmp 1316 2 shao shao NNP cord-015306-us58wwmp 1316 3 Nephrology Nephrology NNP cord-015306-us58wwmp 1316 4 , , , cord-015306-us58wwmp 1316 5 guiyang guiyang NNP cord-015306-us58wwmp 1316 6 children child NNS cord-015306-us58wwmp 1316 7 's 's POS cord-015306-us58wwmp 1316 8 hospital hospital NN cord-015306-us58wwmp 1316 9 , , , cord-015306-us58wwmp 1316 10 Guizhou Guizhou NNP cord-015306-us58wwmp 1316 11 , , , cord-015306-us58wwmp 1317 1 China China NNP cord-015306-us58wwmp 1317 2 Objective Objective NNP cord-015306-us58wwmp 1317 3 : : : cord-015306-us58wwmp 1318 1 Interleukin Interleukin NNP cord-015306-us58wwmp 1318 2 ( ( -LRB- cord-015306-us58wwmp 1318 3 IL)-17 il)-17 NN cord-015306-us58wwmp 1318 4 and and CC cord-015306-us58wwmp 1318 5 Th17 Th17 NNP cord-015306-us58wwmp 1318 6 cells cell NNS cord-015306-us58wwmp 1318 7 have have VBP cord-015306-us58wwmp 1318 8 been be VBN cord-015306-us58wwmp 1318 9 involved involve VBN cord-015306-us58wwmp 1318 10 in in IN cord-015306-us58wwmp 1318 11 many many JJ cord-015306-us58wwmp 1318 12 autoimmune autoimmune JJ cord-015306-us58wwmp 1318 13 diseases disease NNS cord-015306-us58wwmp 1318 14 . . . cord-015306-us58wwmp 1319 1 The the DT cord-015306-us58wwmp 1319 2 aim aim NN cord-015306-us58wwmp 1319 3 of of IN cord-015306-us58wwmp 1319 4 this this DT cord-015306-us58wwmp 1319 5 study study NN cord-015306-us58wwmp 1319 6 is be VBZ cord-015306-us58wwmp 1319 7 to to TO cord-015306-us58wwmp 1319 8 investigate investigate VB cord-015306-us58wwmp 1319 9 the the DT cord-015306-us58wwmp 1319 10 involvement involvement NN cord-015306-us58wwmp 1319 11 ofIL-17 ofIL-17 NNP cord-015306-us58wwmp 1319 12 and and CC cord-015306-us58wwmp 1320 1 Th17 th17 NN cord-015306-us58wwmp 1320 2 cells cell NNS cord-015306-us58wwmp 1320 3 in in IN cord-015306-us58wwmp 1320 4 the the DT cord-015306-us58wwmp 1320 5 pathogenesis pathogenesis NN cord-015306-us58wwmp 1320 6 of of IN cord-015306-us58wwmp 1320 7 childhood childhood NN cord-015306-us58wwmp 1320 8 Henoch Henoch NNP cord-015306-us58wwmp 1320 9 - - HYPH cord-015306-us58wwmp 1320 10 Schonlein Schonlein NNP cord-015306-us58wwmp 1320 11 purpura purpura NN cord-015306-us58wwmp 1320 12 ( ( -LRB- cord-015306-us58wwmp 1320 13 HSPN HSPN NNP cord-015306-us58wwmp 1320 14 ) ) -RRB- cord-015306-us58wwmp 1320 15 . . . cord-015306-us58wwmp 1321 1 Methods method NNS cord-015306-us58wwmp 1321 2 : : : cord-015306-us58wwmp 1322 1 Serum serum NN cord-015306-us58wwmp 1322 2 and and CC cord-015306-us58wwmp 1322 3 supernatant supernatant JJ cord-015306-us58wwmp 1322 4 levels level NNS cord-015306-us58wwmp 1322 5 ofcytokines ofcytokine NNS cord-015306-us58wwmp 1322 6 and and CC cord-015306-us58wwmp 1322 7 chemokines chemokine NNS cord-015306-us58wwmp 1322 8 were be VBD cord-015306-us58wwmp 1322 9 analyzed analyze VBN cord-015306-us58wwmp 1322 10 by by IN cord-015306-us58wwmp 1322 11 enzyme enzyme NN cord-015306-us58wwmp 1322 12 - - HYPH cord-015306-us58wwmp 1322 13 linked link VBN cord-015306-us58wwmp 1322 14 immunosorbent immunosorbent JJ cord-015306-us58wwmp 1322 15 assay assay NN cord-015306-us58wwmp 1322 16 ( ( -LRB- cord-015306-us58wwmp 1322 17 ELISA ELISA NNP cord-015306-us58wwmp 1322 18 ) ) -RRB- cord-015306-us58wwmp 1322 19 . . . cord-015306-us58wwmp 1323 1 Using use VBG cord-015306-us58wwmp 1323 2 intracellular intracellular JJ cord-015306-us58wwmp 1323 3 staining staining NN cord-015306-us58wwmp 1323 4 , , , cord-015306-us58wwmp 1323 5 the the DT cord-015306-us58wwmp 1323 6 frequency frequency NN cord-015306-us58wwmp 1323 7 ofperipheral ofperipheral NNP cord-015306-us58wwmp 1323 8 Th17 Th17 NNP cord-015306-us58wwmp 1324 1 and and CC cord-015306-us58wwmp 1324 2 Th1 th1 NN cord-015306-us58wwmp 1324 3 cells cell NNS cord-015306-us58wwmp 1324 4 was be VBD cord-015306-us58wwmp 1324 5 studied study VBN cord-015306-us58wwmp 1324 6 by by IN cord-015306-us58wwmp 1324 7 flow flow NN cord-015306-us58wwmp 1324 8 cytometry cytometry NN cord-015306-us58wwmp 1324 9 . . . cord-015306-us58wwmp 1325 1 Results result NNS cord-015306-us58wwmp 1325 2 : : : cord-015306-us58wwmp 1326 1 Children child NNS cord-015306-us58wwmp 1326 2 with with IN cord-015306-us58wwmp 1326 3 HSPN HSPN NNP cord-015306-us58wwmp 1326 4 had have VBD cord-015306-us58wwmp 1326 5 significantly significantly RB cord-015306-us58wwmp 1326 6 higher high JJR cord-015306-us58wwmp 1326 7 serum serum NN cord-015306-us58wwmp 1326 8 levels level NNS cord-015306-us58wwmp 1326 9 of of IN cord-015306-us58wwmp 1326 10 IL-17 IL-17 NNP cord-015306-us58wwmp 1326 11 , , , cord-015306-us58wwmp 1326 12 IL-6and il-6and VB cord-015306-us58wwmp 1326 13 transforming transform VBG cord-015306-us58wwmp 1326 14 growth growth NN cord-015306-us58wwmp 1326 15 factor factor NN cord-015306-us58wwmp 1326 16 - - HYPH cord-015306-us58wwmp 1326 17 beta beta NN cord-015306-us58wwmp 1326 18 than than IN cord-015306-us58wwmp 1326 19 healthy healthy JJ cord-015306-us58wwmp 1326 20 controls control NNS cord-015306-us58wwmp 1326 21 . . . cord-015306-us58wwmp 1327 1 The the DT cord-015306-us58wwmp 1327 2 IL-17 IL-17 NNP cord-015306-us58wwmp 1327 3 levels level NNS cord-015306-us58wwmp 1327 4 in in IN cord-015306-us58wwmp 1327 5 culture culture NN cord-015306-us58wwmp 1327 6 supernatants supernatant NNS cord-015306-us58wwmp 1327 7 of of IN cord-015306-us58wwmp 1327 8 peripheral peripheral JJ cord-015306-us58wwmp 1327 9 blood blood NN cord-015306-us58wwmp 1327 10 mononuclear mononuclear NN cord-015306-us58wwmp 1327 11 cells cell NNS cord-015306-us58wwmp 1327 12 with with IN cord-015306-us58wwmp 1327 13 anti anti JJ cord-015306-us58wwmp 1327 14 - - JJ cord-015306-us58wwmp 1327 15 CD3 CD3 NNP cord-015306-us58wwmp 1327 16 and and CC cord-015306-us58wwmp 1327 17 CD28 CD28 NNP cord-015306-us58wwmp 1327 18 antibody antibody NN cord-015306-us58wwmp 1327 19 stimulation stimulation NN cord-015306-us58wwmp 1327 20 were be VBD cord-015306-us58wwmp 1327 21 much much RB cord-015306-us58wwmp 1327 22 higher high JJR cord-015306-us58wwmp 1327 23 in in IN cord-015306-us58wwmp 1327 24 patients patient NNS cord-015306-us58wwmp 1327 25 with with IN cord-015306-us58wwmp 1327 26 HSPN HSPN NNP cord-015306-us58wwmp 1327 27 ( ( -LRB- cord-015306-us58wwmp 1327 28 212.2 212.2 CD cord-015306-us58wwmp 1327 29 + + CC cord-015306-us58wwmp 1327 30 /− /− . cord-015306-us58wwmp 1327 31 71.4 71.4 CD cord-015306-us58wwmp 1327 32 vs. vs. FW cord-015306-us58wwmp 1327 33 34.7 34.7 CD cord-015306-us58wwmp 1327 34 + + CC cord-015306-us58wwmp 1327 35 /− /− . cord-015306-us58wwmp 1327 36 12.6 12.6 CD cord-015306-us58wwmp 1327 37 pg pg NNP cord-015306-us58wwmp 1327 38 / / SYM cord-015306-us58wwmp 1327 39 ml ml NN cord-015306-us58wwmp 1327 40 , , , cord-015306-us58wwmp 1327 41 p p NN cord-015306-us58wwmp 1327 42 = = SYM cord-015306-us58wwmp 1327 43 0.021 0.021 CD cord-015306-us58wwmp 1327 44 ) ) -RRB- cord-015306-us58wwmp 1327 45 . . . cord-015306-us58wwmp 1328 1 Thepatients Thepatients NNP cord-015306-us58wwmp 1328 2 also also RB cord-015306-us58wwmp 1328 3 had have VBD cord-015306-us58wwmp 1328 4 more more JJR cord-015306-us58wwmp 1328 5 Th17 th17 NN cord-015306-us58wwmp 1328 6 cells cell NNS cord-015306-us58wwmp 1328 7 ( ( -LRB- cord-015306-us58wwmp 1328 8 1.47 1.47 CD cord-015306-us58wwmp 1328 9 + + CC cord-015306-us58wwmp 1328 10 /− /− . cord-015306-us58wwmp 1328 11 0.23 0.23 CD cord-015306-us58wwmp 1328 12 % % NN cord-015306-us58wwmp 1328 13 vs. vs. NN cord-015306-us58wwmp 1328 14 0.61 0.61 CD cord-015306-us58wwmp 1328 15 + + CD cord-015306-us58wwmp 1329 1 /− /− . cord-015306-us58wwmp 1330 1 0.10 0.10 CD cord-015306-us58wwmp 1330 2 % % NN cord-015306-us58wwmp 1330 3 , , , cord-015306-us58wwmp 1330 4 p p NN cord-015306-us58wwmp 1330 5 = = SYM cord-015306-us58wwmp 1330 6 0.012 0.012 CD cord-015306-us58wwmp 1330 7 ) ) -RRB- cord-015306-us58wwmp 1330 8 but but CC cord-015306-us58wwmp 1330 9 not not RB cord-015306-us58wwmp 1330 10 Th1 th1 NN cord-015306-us58wwmp 1330 11 cells cell NNS cord-015306-us58wwmp 1330 12 in in IN cord-015306-us58wwmp 1330 13 peripheral peripheral JJ cord-015306-us58wwmp 1330 14 blood blood NN cord-015306-us58wwmp 1330 15 . . . cord-015306-us58wwmp 1331 1 Moreover moreover RB cord-015306-us58wwmp 1331 2 , , , cord-015306-us58wwmp 1331 3 IL-17 IL-17 NNP cord-015306-us58wwmp 1331 4 could could MD cord-015306-us58wwmp 1331 5 promote promote VB cord-015306-us58wwmp 1331 6 human human JJ cord-015306-us58wwmp 1331 7 endothelial endothelial JJ cord-015306-us58wwmp 1331 8 cells cell NNS cord-015306-us58wwmp 1331 9 to to TO cord-015306-us58wwmp 1331 10 produce produce VB cord-015306-us58wwmp 1331 11 chemoattractants chemoattractant NNS cord-015306-us58wwmp 1331 12 IL-8 IL-8 NNP cord-015306-us58wwmp 1331 13 and and CC cord-015306-us58wwmp 1331 14 monocyte monocyte NNP cord-015306-us58wwmp 1331 15 chemotactic chemotactic VBD cord-015306-us58wwmp 1331 16 protein-1 protein-1 NNP cord-015306-us58wwmp 1331 17 . . . cord-015306-us58wwmp 1332 1 The the DT cord-015306-us58wwmp 1332 2 increased increase VBN cord-015306-us58wwmp 1332 3 frequency frequency NN cord-015306-us58wwmp 1332 4 of of IN cord-015306-us58wwmp 1332 5 peripheral peripheral JJ cord-015306-us58wwmp 1332 6 Th17 Th17 NNP cord-015306-us58wwmp 1332 7 cells cell NNS cord-015306-us58wwmp 1332 8 and and CC cord-015306-us58wwmp 1332 9 serum serum NN cord-015306-us58wwmp 1332 10 IL-17 IL-17 NNP cord-015306-us58wwmp 1332 11 levels level NNS cord-015306-us58wwmp 1332 12 are be VBP cord-015306-us58wwmp 1332 13 shown show VBN cord-015306-us58wwmp 1332 14 in in IN cord-015306-us58wwmp 1332 15 childhood childhood NN cord-015306-us58wwmp 1332 16 HSPN HSPN NNP cord-015306-us58wwmp 1332 17 that that WDT cord-015306-us58wwmp 1332 18 may may MD cord-015306-us58wwmp 1332 19 in in IN cord-015306-us58wwmp 1332 20 part part NN cord-015306-us58wwmp 1332 21 contribute contribute VB cord-015306-us58wwmp 1332 22 to to IN cord-015306-us58wwmp 1332 23 vascular vascular JJ cord-015306-us58wwmp 1332 24 inflammation inflammation NN cord-015306-us58wwmp 1332 25 , , , cord-015306-us58wwmp 1332 26 suggesting suggest VBG cord-015306-us58wwmp 1332 27 cellular cellular JJ cord-015306-us58wwmp 1332 28 immunity immunity NN cord-015306-us58wwmp 1332 29 is be VBZ cord-015306-us58wwmp 1332 30 likely likely JJ cord-015306-us58wwmp 1332 31 to to TO cord-015306-us58wwmp 1332 32 be be VB cord-015306-us58wwmp 1332 33 involved involve VBN cord-015306-us58wwmp 1332 34 in in IN cord-015306-us58wwmp 1332 35 the the DT cord-015306-us58wwmp 1332 36 process process NN cord-015306-us58wwmp 1332 37 of of IN cord-015306-us58wwmp 1332 38 HSPN HSPN NNP cord-015306-us58wwmp 1332 39 . . . cord-015306-us58wwmp 1333 1 Expression expression NN cord-015306-us58wwmp 1333 2 and and CC cord-015306-us58wwmp 1333 3 significance significance NN cord-015306-us58wwmp 1333 4 of of IN cord-015306-us58wwmp 1333 5 TGF tgf NN cord-015306-us58wwmp 1333 6 - - HYPH cord-015306-us58wwmp 1333 7 beta beta NN cord-015306-us58wwmp 1333 8 , , , cord-015306-us58wwmp 1333 9 Smad7 Smad7 NNP cord-015306-us58wwmp 1333 10 , , , cord-015306-us58wwmp 1333 11 FN FN NNP cord-015306-us58wwmp 1333 12 , , , cord-015306-us58wwmp 1333 13 Ub Ub NNP cord-015306-us58wwmp 1333 14 and and CC cord-015306-us58wwmp 1333 15 Smurf2 Smurf2 NNP cord-015306-us58wwmp 1333 16 in in IN cord-015306-us58wwmp 1333 17 the the DT cord-015306-us58wwmp 1333 18 renal renal JJ cord-015306-us58wwmp 1333 19 tissues tissue NNS cord-015306-us58wwmp 1333 20 of of IN cord-015306-us58wwmp 1333 21 children child NNS cord-015306-us58wwmp 1333 22 with with IN cord-015306-us58wwmp 1333 23 IgA IgA NNP cord-015306-us58wwmp 1333 24 nephropathy nephropathy NN cord-015306-us58wwmp 1333 25 CHEN CHEN NNP cord-015306-us58wwmp 1333 26 Li Li NNP cord-015306-us58wwmp 1333 27 - - HYPH cord-015306-us58wwmp 1333 28 zhi zhi NNP cord-015306-us58wwmp 1333 29 , , , cord-015306-us58wwmp 1333 30 JIANG JIANG NNP cord-015306-us58wwmp 1333 31 Xiao Xiao NNP cord-015306-us58wwmp 1333 32 - - HYPH cord-015306-us58wwmp 1333 33 yun yun NNP cord-015306-us58wwmp 1333 34 , , , cord-015306-us58wwmp 1333 35 LING LING NNP cord-015306-us58wwmp 1333 36 Yi Yi NNP cord-015306-us58wwmp 1333 37 - - HYPH cord-015306-us58wwmp 1333 38 hong hong NNP cord-015306-us58wwmp 1333 39 , , , cord-015306-us58wwmp 1333 40 MO MO NNP cord-015306-us58wwmp 1333 41 Ying Ying NNP cord-015306-us58wwmp 1333 42 , , , cord-015306-us58wwmp 1333 43 SUN SUN NNP cord-015306-us58wwmp 1333 44 Liang Liang NNP cord-015306-us58wwmp 1333 45 - - HYPH cord-015306-us58wwmp 1333 46 zhong zhong NNP cord-015306-us58wwmp 1333 47 Pediatrics Pediatrics NNP cord-015306-us58wwmp 1333 48 , , , cord-015306-us58wwmp 1333 49 the the DT cord-015306-us58wwmp 1333 50 First First NNP cord-015306-us58wwmp 1333 51 Affiliated Affiliated NNP cord-015306-us58wwmp 1333 52 Hospital Hospital NNP cord-015306-us58wwmp 1333 53 of of IN cord-015306-us58wwmp 1333 54 Sun Sun NNP cord-015306-us58wwmp 1333 55 Yat Yat NNP cord-015306-us58wwmp 1333 56 - - HYPH cord-015306-us58wwmp 1333 57 sen sen NNP cord-015306-us58wwmp 1333 58 University University NNP cord-015306-us58wwmp 1333 59 , , , cord-015306-us58wwmp 1333 60 Guangzhou Guangzhou NNP cord-015306-us58wwmp 1333 61 , , , cord-015306-us58wwmp 1334 1 China China NNP cord-015306-us58wwmp 1334 2 Objective Objective NNP cord-015306-us58wwmp 1335 1 : : : cord-015306-us58wwmp 1335 2 In in IN cord-015306-us58wwmp 1335 3 this this DT cord-015306-us58wwmp 1335 4 study study NN cord-015306-us58wwmp 1335 5 , , , cord-015306-us58wwmp 1335 6 we -PRON- PRP cord-015306-us58wwmp 1335 7 investigated investigate VBD cord-015306-us58wwmp 1335 8 the the DT cord-015306-us58wwmp 1335 9 expression expression NN cord-015306-us58wwmp 1335 10 of of IN cord-015306-us58wwmp 1335 11 TGF TGF NNP cord-015306-us58wwmp 1335 12 - - HYPH cord-015306-us58wwmp 1335 13 beta beta NN cord-015306-us58wwmp 1335 14 1 1 CD cord-015306-us58wwmp 1335 15 , , , cord-015306-us58wwmp 1335 16 Smad7 Smad7 NNP cord-015306-us58wwmp 1335 17 , , , cord-015306-us58wwmp 1335 18 SnoN SnoN NNP cord-015306-us58wwmp 1335 19 , , , cord-015306-us58wwmp 1335 20 FN FN NNP cord-015306-us58wwmp 1335 21 , , , cord-015306-us58wwmp 1335 22 Ub Ub NNP cord-015306-us58wwmp 1335 23 and and CC cord-015306-us58wwmp 1335 24 Smurf2 Smurf2 NNP cord-015306-us58wwmp 1336 1 inthe inthe JJ cord-015306-us58wwmp 1336 2 renal renal JJ cord-015306-us58wwmp 1336 3 tissues tissue NNS cord-015306-us58wwmp 1336 4 in in IN cord-015306-us58wwmp 1336 5 children child NNS cord-015306-us58wwmp 1336 6 with with IN cord-015306-us58wwmp 1336 7 IgAN IgAN NNP cord-015306-us58wwmp 1336 8 , , , cord-015306-us58wwmp 1336 9 in in IN cord-015306-us58wwmp 1336 10 order order NN cord-015306-us58wwmp 1336 11 to to TO cord-015306-us58wwmp 1336 12 explore explore VB cord-015306-us58wwmp 1336 13 the the DT cord-015306-us58wwmp 1336 14 potential potential JJ cord-015306-us58wwmp 1336 15 cross cross NN cord-015306-us58wwmp 1336 16 - - NN cord-015306-us58wwmp 1336 17 talk talk NN cord-015306-us58wwmp 1336 18 between between IN cord-015306-us58wwmp 1336 19 ubiquitinproteasome ubiquitinproteasome NN cord-015306-us58wwmp 1336 20 pathway pathway NN cord-015306-us58wwmp 1336 21 and and CC cord-015306-us58wwmp 1336 22 TGF TGF NNP cord-015306-us58wwmp 1336 23 - - HYPH cord-015306-us58wwmp 1336 24 beta beta NN cord-015306-us58wwmp 1336 25 1 1 CD cord-015306-us58wwmp 1336 26 signaling signal VBG cord-015306-us58wwmp 1336 27 and and CC cord-015306-us58wwmp 1336 28 even even RB cord-015306-us58wwmp 1336 29 their -PRON- PRP$ cord-015306-us58wwmp 1336 30 role role NN cord-015306-us58wwmp 1336 31 in in IN cord-015306-us58wwmp 1336 32 the the DT cord-015306-us58wwmp 1336 33 progressive progressive JJ cord-015306-us58wwmp 1336 34 renal renal JJ cord-015306-us58wwmp 1336 35 fibrogenesis fibrogenesis NN cord-015306-us58wwmp 1336 36 of of IN cord-015306-us58wwmp 1336 37 IgAN IgAN NNP cord-015306-us58wwmp 1336 38 . . . cord-015306-us58wwmp 1337 1 Methods method NNS cord-015306-us58wwmp 1337 2 : : : cord-015306-us58wwmp 1337 3 Sixty sixty CD cord-015306-us58wwmp 1337 4 children child NNS cord-015306-us58wwmp 1337 5 with with IN cord-015306-us58wwmp 1337 6 IgAN IgAN NNP cord-015306-us58wwmp 1337 7 were be VBD cord-015306-us58wwmp 1337 8 divided divide VBN cord-015306-us58wwmp 1337 9 into into IN cord-015306-us58wwmp 1337 10 three three CD cord-015306-us58wwmp 1337 11 groups group NNS cord-015306-us58wwmp 1337 12 according accord VBG cord-015306-us58wwmp 1337 13 to to IN cord-015306-us58wwmp 1337 14 their -PRON- PRP$ cord-015306-us58wwmp 1337 15 clinical clinical JJ cord-015306-us58wwmp 1337 16 features feature NNS cord-015306-us58wwmp 1337 17 : : : cord-015306-us58wwmp 1337 18 isolated isolate VBN cord-015306-us58wwmp 1337 19 haematuria haematuria NNP cord-015306-us58wwmp 1337 20 group group NN cord-015306-us58wwmp 1337 21 ( ( -LRB- cord-015306-us58wwmp 1337 22 IHgroup IHgroup NNP cord-015306-us58wwmp 1337 23 , , , cord-015306-us58wwmp 1337 24 20 20 CD cord-015306-us58wwmp 1337 25 patients patient NNS cord-015306-us58wwmp 1337 26 ) ) -RRB- cord-015306-us58wwmp 1337 27 , , , cord-015306-us58wwmp 1337 28 hematuria hematuria NN cord-015306-us58wwmp 1337 29 and and CC cord-015306-us58wwmp 1337 30 proteinuria proteinuria NN cord-015306-us58wwmp 1337 31 group group NN cord-015306-us58wwmp 1337 32 ( ( -LRB- cord-015306-us58wwmp 1337 33 HP HP NNP cord-015306-us58wwmp 1337 34 group group NN cord-015306-us58wwmp 1337 35 , , , cord-015306-us58wwmp 1337 36 21 21 CD cord-015306-us58wwmp 1337 37 ) ) -RRB- cord-015306-us58wwmp 1337 38 , , , cord-015306-us58wwmp 1337 39 and and CC cord-015306-us58wwmp 1337 40 nephrotic nephrotic JJ cord-015306-us58wwmp 1337 41 syndrome syndrome NN cord-015306-us58wwmp 1337 42 group group NN cord-015306-us58wwmp 1337 43 ( ( -LRB- cord-015306-us58wwmp 1337 44 NS NS NNP cord-015306-us58wwmp 1337 45 group group NN cord-015306-us58wwmp 1337 46 , , , cord-015306-us58wwmp 1337 47 19 19 CD cord-015306-us58wwmp 1337 48 ) ) -RRB- cord-015306-us58wwmp 1337 49 . . . cord-015306-us58wwmp 1338 1 Patients patient NNS cord-015306-us58wwmp 1338 2 were be VBD cord-015306-us58wwmp 1338 3 also also RB cord-015306-us58wwmp 1338 4 divided divide VBN cord-015306-us58wwmp 1338 5 into into IN cord-015306-us58wwmp 1338 6 three three CD cord-015306-us58wwmp 1338 7 groups group NNS cord-015306-us58wwmp 1338 8 according accord VBG cord-015306-us58wwmp 1338 9 to to IN cord-015306-us58wwmp 1338 10 pathologic pathologic JJ cord-015306-us58wwmp 1338 11 grades grade NNS cord-015306-us58wwmp 1338 12 : : : cord-015306-us58wwmp 1338 13 grade grade NN cord-015306-us58wwmp 1338 14 2 2 CD cord-015306-us58wwmp 1338 15 ( ( -LRB- cord-015306-us58wwmp 1338 16 26 26 CD cord-015306-us58wwmp 1338 17 patients patient NNS cord-015306-us58wwmp 1338 18 ) ) -RRB- cord-015306-us58wwmp 1338 19 , , , cord-015306-us58wwmp 1338 20 grade grade NN cord-015306-us58wwmp 1338 21 3 3 CD cord-015306-us58wwmp 1338 22 ( ( -LRB- cord-015306-us58wwmp 1338 23 20 20 CD cord-015306-us58wwmp 1338 24 ) ) -RRB- cord-015306-us58wwmp 1338 25 and and CC cord-015306-us58wwmp 1338 26 grade grade NN cord-015306-us58wwmp 1338 27 4 4 CD cord-015306-us58wwmp 1338 28 ( ( -LRB- cord-015306-us58wwmp 1338 29 14 14 CD cord-015306-us58wwmp 1338 30 ) ) -RRB- cord-015306-us58wwmp 1338 31 groups group NNS cord-015306-us58wwmp 1338 32 . . . cord-015306-us58wwmp 1339 1 Six six CD cord-015306-us58wwmp 1339 2 normal normal JJ cord-015306-us58wwmp 1339 3 renal renal JJ cord-015306-us58wwmp 1339 4 specimens specimen NNS cord-015306-us58wwmp 1339 5 ( ( -LRB- cord-015306-us58wwmp 1339 6 four four CD cord-015306-us58wwmp 1339 7 was be VBD cord-015306-us58wwmp 1339 8 non non JJ cord-015306-us58wwmp 1339 9 - - JJ cord-015306-us58wwmp 1339 10 tumor tumor JJ cord-015306-us58wwmp 1339 11 kidney kidney NN cord-015306-us58wwmp 1339 12 tissues tissue NNS cord-015306-us58wwmp 1339 13 from from IN cord-015306-us58wwmp 1339 14 patients patient NNS cord-015306-us58wwmp 1339 15 who who WP cord-015306-us58wwmp 1339 16 had have VBD cord-015306-us58wwmp 1339 17 renal renal JJ cord-015306-us58wwmp 1339 18 tumor tumor NN cord-015306-us58wwmp 1339 19 and and CC cord-015306-us58wwmp 1339 20 underwent undergo VBD cord-015306-us58wwmp 1339 21 nehprectomy nehprectomy NN cord-015306-us58wwmp 1339 22 , , , cord-015306-us58wwmp 1339 23 another another DT cord-015306-us58wwmp 1339 24 two two CD cord-015306-us58wwmp 1339 25 was be VBD cord-015306-us58wwmp 1339 26 healthmismatched healthmismatche VBN cord-015306-us58wwmp 1339 27 donor donor NN cord-015306-us58wwmp 1339 28 renal renal JJ cord-015306-us58wwmp 1339 29 tissues tissue NNS cord-015306-us58wwmp 1339 30 before before IN cord-015306-us58wwmp 1339 31 renal renal JJ cord-015306-us58wwmp 1339 32 transplantation transplantation NN cord-015306-us58wwmp 1339 33 ) ) -RRB- cord-015306-us58wwmp 1339 34 were be VBD cord-015306-us58wwmp 1339 35 used use VBN cord-015306-us58wwmp 1339 36 as as IN cord-015306-us58wwmp 1339 37 the the DT cord-015306-us58wwmp 1339 38 control control NN cord-015306-us58wwmp 1339 39 group group NN cord-015306-us58wwmp 1339 40 . . . cord-015306-us58wwmp 1340 1 The the DT cord-015306-us58wwmp 1340 2 expression expression NN cord-015306-us58wwmp 1340 3 of of IN cord-015306-us58wwmp 1340 4 Ub Ub NNP cord-015306-us58wwmp 1340 5 , , , cord-015306-us58wwmp 1340 6 Smurf2 Smurf2 NNP cord-015306-us58wwmp 1340 7 , , , cord-015306-us58wwmp 1340 8 TGF-1 TGF-1 NNP cord-015306-us58wwmp 1340 9 , , , cord-015306-us58wwmp 1340 10 Smad7 Smad7 NNP cord-015306-us58wwmp 1340 11 , , , cord-015306-us58wwmp 1340 12 SnoN SnoN NNP cord-015306-us58wwmp 1340 13 , , , cord-015306-us58wwmp 1340 14 and and CC cord-015306-us58wwmp 1340 15 FN FN NNP cord-015306-us58wwmp 1340 16 in in IN cord-015306-us58wwmp 1340 17 renal renal JJ cord-015306-us58wwmp 1340 18 tissues tissue NNS cord-015306-us58wwmp 1340 19 were be VBD cord-015306-us58wwmp 1340 20 determined determine VBN cord-015306-us58wwmp 1340 21 by by IN cord-015306-us58wwmp 1340 22 immunohistochemistry immunohistochemistry NN cord-015306-us58wwmp 1340 23 ( ( -LRB- cord-015306-us58wwmp 1340 24 two two CD cord-015306-us58wwmp 1340 25 - - HYPH cord-015306-us58wwmp 1340 26 step step NN cord-015306-us58wwmp 1340 27 PowerVisionTM PowerVisionTM '' cord-015306-us58wwmp 1340 28 ) ) -RRB- cord-015306-us58wwmp 1340 29 and and CC cord-015306-us58wwmp 1340 30 semi semi RB cord-015306-us58wwmp 1340 31 - - JJ cord-015306-us58wwmp 1340 32 quantitatively quantitatively RB cord-015306-us58wwmp 1340 33 analyzed analyze VBN cord-015306-us58wwmp 1340 34 by by IN cord-015306-us58wwmp 1340 35 the the DT cord-015306-us58wwmp 1340 36 software software NN cord-015306-us58wwmp 1340 37 of of IN cord-015306-us58wwmp 1340 38 Image image NN cord-015306-us58wwmp 1340 39 - - HYPH cord-015306-us58wwmp 1340 40 Pro Pro NNP cord-015306-us58wwmp 1340 41 Plus plus CC cord-015306-us58wwmp 1340 42 6.0 6.0 CD cord-015306-us58wwmp 1340 43 . . . cord-015306-us58wwmp 1341 1 The the DT cord-015306-us58wwmp 1341 2 degrees degree NNS cord-015306-us58wwmp 1341 3 of of IN cord-015306-us58wwmp 1341 4 glomerular glomerular JJ cord-015306-us58wwmp 1341 5 and and CC cord-015306-us58wwmp 1341 6 tubulointerstitial tubulointerstitial JJ cord-015306-us58wwmp 1341 7 lesions lesion NNS cord-015306-us58wwmp 1341 8 were be VBD cord-015306-us58wwmp 1341 9 scored score VBN cord-015306-us58wwmp 1341 10 according accord VBG cord-015306-us58wwmp 1341 11 to to IN cord-015306-us58wwmp 1341 12 the the DT cord-015306-us58wwmp 1341 13 Katafuchi Katafuchi NNP cord-015306-us58wwmp 1341 14 semi semi JJ cord-015306-us58wwmp 1341 15 - - JJ cord-015306-us58wwmp 1341 16 quantitative quantitative JJ cord-015306-us58wwmp 1341 17 criteria criterion NNS cord-015306-us58wwmp 1341 18 . . . cord-015306-us58wwmp 1342 1 Results result NNS cord-015306-us58wwmp 1342 2 : : : cord-015306-us58wwmp 1343 1 The the DT cord-015306-us58wwmp 1343 2 expression expression NN cord-015306-us58wwmp 1343 3 of of IN cord-015306-us58wwmp 1343 4 TGF TGF NNP cord-015306-us58wwmp 1343 5 - - HYPH cord-015306-us58wwmp 1343 6 beta beta NN cord-015306-us58wwmp 1343 7 1 1 CD cord-015306-us58wwmp 1343 8 , , , cord-015306-us58wwmp 1343 9 FN FN NNP cord-015306-us58wwmp 1343 10 , , , cord-015306-us58wwmp 1343 11 Ub Ub NNP cord-015306-us58wwmp 1343 12 and and CC cord-015306-us58wwmp 1343 13 Smurf2 Smurf2 NNP cord-015306-us58wwmp 1343 14 inIgAN inIgAN VBN cord-015306-us58wwmp 1343 15 kidneys kidney NNS cord-015306-us58wwmp 1343 16 was be VBD cord-015306-us58wwmp 1343 17 significantly significantly RB cord-015306-us58wwmp 1343 18 higher high JJR cord-015306-us58wwmp 1343 19 than than IN cord-015306-us58wwmp 1343 20 that that DT cord-015306-us58wwmp 1343 21 in in IN cord-015306-us58wwmp 1343 22 the the DT cord-015306-us58wwmp 1343 23 control control NN cord-015306-us58wwmp 1343 24 group(Pless group(pless NN cord-015306-us58wwmp 1343 25 than than IN cord-015306-us58wwmp 1343 26 0.01 0.01 CD cord-015306-us58wwmp 1343 27 ) ) -RRB- cord-015306-us58wwmp 1343 28 , , , cord-015306-us58wwmp 1343 29 while while IN cord-015306-us58wwmp 1343 30 the the DT cord-015306-us58wwmp 1343 31 increased increase VBN cord-015306-us58wwmp 1343 32 expression expression NN cord-015306-us58wwmp 1343 33 of of IN cord-015306-us58wwmp 1343 34 Smad7 Smad7 NNP cord-015306-us58wwmp 1343 35 was be VBD cord-015306-us58wwmp 1343 36 only only RB cord-015306-us58wwmp 1343 37 found find VBN cord-015306-us58wwmp 1343 38 in in IN cord-015306-us58wwmp 1343 39 glomeruli glomerulus NNS cord-015306-us58wwmp 1343 40 but but CC cord-015306-us58wwmp 1343 41 not not RB cord-015306-us58wwmp 1343 42 in in IN cord-015306-us58wwmp 1343 43 renal renal JJ cord-015306-us58wwmp 1343 44 tubular tubular JJ cord-015306-us58wwmp 1343 45 interstitium(P interstitium(P . cord-015306-us58wwmp 1344 1 less less JJR cord-015306-us58wwmp 1344 2 than than IN cord-015306-us58wwmp 1344 3 0.01 0.01 CD cord-015306-us58wwmp 1344 4 ) ) -RRB- cord-015306-us58wwmp 1344 5 . . . cord-015306-us58wwmp 1345 1 The the DT cord-015306-us58wwmp 1345 2 highest high JJS cord-015306-us58wwmp 1345 3 expression expression NN cord-015306-us58wwmp 1345 4 of of IN cord-015306-us58wwmp 1345 5 TGF TGF NNP cord-015306-us58wwmp 1345 6 - - HYPH cord-015306-us58wwmp 1345 7 beta beta NN cord-015306-us58wwmp 1345 8 1 1 CD cord-015306-us58wwmp 1345 9 , , , cord-015306-us58wwmp 1345 10 FN FN NNP cord-015306-us58wwmp 1345 11 , , , cord-015306-us58wwmp 1345 12 and and CC cord-015306-us58wwmp 1345 13 Ub Ub NNP cord-015306-us58wwmp 1345 14 were be VBD cord-015306-us58wwmp 1345 15 found find VBN cord-015306-us58wwmp 1345 16 in in IN cord-015306-us58wwmp 1345 17 the the DT cord-015306-us58wwmp 1345 18 NS NS NNP cord-015306-us58wwmp 1345 19 and and CC cord-015306-us58wwmp 1345 20 grade grade NN cord-015306-us58wwmp 1345 21 4 4 CD cord-015306-us58wwmp 1345 22 groups(P groups(p CD cord-015306-us58wwmp 1345 23 less less JJR cord-015306-us58wwmp 1345 24 than than IN cord-015306-us58wwmp 1345 25 0.01 0.01 CD cord-015306-us58wwmp 1345 26 ) ) -RRB- cord-015306-us58wwmp 1345 27 , , , cord-015306-us58wwmp 1345 28 Smurf2 Smurf2 NNP cord-015306-us58wwmp 1345 29 in in IN cord-015306-us58wwmp 1345 30 the the DT cord-015306-us58wwmp 1345 31 IH IH NNP cord-015306-us58wwmp 1345 32 and and CC cord-015306-us58wwmp 1345 33 grade grade NN cord-015306-us58wwmp 1345 34 2 2 CD cord-015306-us58wwmp 1345 35 groups(P groups(P . cord-015306-us58wwmp 1346 1 less less JJR cord-015306-us58wwmp 1346 2 than than IN cord-015306-us58wwmp 1346 3 0.01 0.01 CD cord-015306-us58wwmp 1346 4 ) ) -RRB- cord-015306-us58wwmp 1346 5 , , , cord-015306-us58wwmp 1346 6 while while IN cord-015306-us58wwmp 1346 7 the the DT cord-015306-us58wwmp 1346 8 lowest low JJS cord-015306-us58wwmp 1346 9 expression expression NN cord-015306-us58wwmp 1346 10 of of IN cord-015306-us58wwmp 1346 11 Smad7 Smad7 NNP cord-015306-us58wwmp 1346 12 was be VBD cord-015306-us58wwmp 1346 13 found find VBN cord-015306-us58wwmp 1346 14 in in IN cord-015306-us58wwmp 1346 15 the the DT cord-015306-us58wwmp 1346 16 grade grade NN cord-015306-us58wwmp 1346 17 4 4 CD cord-015306-us58wwmp 1347 1 group(P group(p DT cord-015306-us58wwmp 1348 1 less less JJR cord-015306-us58wwmp 1348 2 than than IN cord-015306-us58wwmp 1348 3 0.01 0.01 CD cord-015306-us58wwmp 1348 4 ) ) -RRB- cord-015306-us58wwmp 1349 1 , , , cord-015306-us58wwmp 1349 2 closely closely RB cord-015306-us58wwmp 1349 3 associated associate VBN cord-015306-us58wwmp 1349 4 with with IN cord-015306-us58wwmp 1349 5 different different JJ cord-015306-us58wwmp 1349 6 clinical clinical JJ cord-015306-us58wwmp 1349 7 and and CC cord-015306-us58wwmp 1349 8 pathological pathological JJ cord-015306-us58wwmp 1349 9 groups group NNS cord-015306-us58wwmp 1349 10 . . . cord-015306-us58wwmp 1350 1 ( ( -LRB- cord-015306-us58wwmp 1350 2 P p NN cord-015306-us58wwmp 1350 3 less less JJR cord-015306-us58wwmp 1350 4 than than IN cord-015306-us58wwmp 1350 5 0.01 0.01 CD cord-015306-us58wwmp 1350 6 ) ) -RRB- cord-015306-us58wwmp 1351 1 Conclusion conclusion NN cord-015306-us58wwmp 1351 2 : : : cord-015306-us58wwmp 1352 1 These these DT cord-015306-us58wwmp 1352 2 results result NNS cord-015306-us58wwmp 1352 3 demonstrate demonstrate VBP cord-015306-us58wwmp 1352 4 that that IN cord-015306-us58wwmp 1352 5 UPP UPP NNP cord-015306-us58wwmp 1352 6 and and CC cord-015306-us58wwmp 1352 7 TGF tgf NN cord-015306-us58wwmp 1352 8 - - HYPH cord-015306-us58wwmp 1352 9 beta beta NN cord-015306-us58wwmp 1352 10 1 1 CD cord-015306-us58wwmp 1353 1 /Smads /Smads NNP cord-015306-us58wwmp 1353 2 signaling signal VBG cord-015306-us58wwmp 1353 3 pathway pathway NN cord-015306-us58wwmp 1353 4 were be VBD cord-015306-us58wwmp 1353 5 both both DT cord-015306-us58wwmp 1353 6 activated activate VBN cord-015306-us58wwmp 1353 7 in in IN cord-015306-us58wwmp 1353 8 children child NNS cord-015306-us58wwmp 1353 9 with with IN cord-015306-us58wwmp 1353 10 IgAN.Both IgAN.Both NNP cord-015306-us58wwmp 1353 11 UPP UPP NNP cord-015306-us58wwmp 1353 12 and and CC cord-015306-us58wwmp 1353 13 TGF- TGF- NNP cord-015306-us58wwmp 1354 1 beta beta NN cord-015306-us58wwmp 1354 2 1 1 CD cord-015306-us58wwmp 1354 3 / / SYM cord-015306-us58wwmp 1354 4 Smads Smads NNP cord-015306-us58wwmp 1354 5 signaling signal VBG cord-015306-us58wwmp 1354 6 pathway pathway NN cord-015306-us58wwmp 1354 7 may may MD cord-015306-us58wwmp 1354 8 play play VB cord-015306-us58wwmp 1354 9 an an DT cord-015306-us58wwmp 1354 10 important important JJ cord-015306-us58wwmp 1354 11 role role NN cord-015306-us58wwmp 1354 12 in in IN cord-015306-us58wwmp 1354 13 the the DT cord-015306-us58wwmp 1354 14 progress progress NN cord-015306-us58wwmp 1354 15 of of IN cord-015306-us58wwmp 1354 16 glomerular glomerular JJ cord-015306-us58wwmp 1354 17 sclerosis sclerosis NN cord-015306-us58wwmp 1354 18 , , , cord-015306-us58wwmp 1354 19 renal renal JJ cord-015306-us58wwmp 1354 20 tubular tubular JJ cord-015306-us58wwmp 1354 21 injury injury NN cord-015306-us58wwmp 1354 22 and and CC cord-015306-us58wwmp 1354 23 renal renal JJ cord-015306-us58wwmp 1354 24 interstitial interstitial JJ cord-015306-us58wwmp 1354 25 fibrosis fibrosis NN cord-015306-us58wwmp 1354 26 in in IN cord-015306-us58wwmp 1354 27 children child NNS cord-015306-us58wwmp 1354 28 with with IN cord-015306-us58wwmp 1354 29 IgAN IgAN NNP cord-015306-us58wwmp 1354 30 . . . cord-015306-us58wwmp 1355 1 Abstract abstract JJ cord-015306-us58wwmp 1355 2 # # NN cord-015306-us58wwmp 1355 3 P p NN cord-015306-us58wwmp 1355 4 - - HYPH cord-015306-us58wwmp 1355 5 SAT166 SAT166 NNP cord-015306-us58wwmp 1355 6 Objective objective NN cord-015306-us58wwmp 1355 7 : : : cord-015306-us58wwmp 1355 8 The the DT cord-015306-us58wwmp 1355 9 Proteasome Proteasome NNP cord-015306-us58wwmp 1355 10 ( ( -LRB- cord-015306-us58wwmp 1355 11 PS PS NNP cord-015306-us58wwmp 1355 12 ) ) -RRB- cord-015306-us58wwmp 1355 13 plays play VBZ cord-015306-us58wwmp 1355 14 a a DT cord-015306-us58wwmp 1355 15 key key JJ cord-015306-us58wwmp 1355 16 role role NN cord-015306-us58wwmp 1355 17 in in IN cord-015306-us58wwmp 1355 18 the the DT cord-015306-us58wwmp 1355 19 activation activation NN cord-015306-us58wwmp 1355 20 of of IN cord-015306-us58wwmp 1355 21 transcriptional transcriptional JJ cord-015306-us58wwmp 1355 22 factors factor NNS cord-015306-us58wwmp 1355 23 , , , cord-015306-us58wwmp 1355 24 cytokines cytokine NNS cord-015306-us58wwmp 1355 25 and and CC cord-015306-us58wwmp 1355 26 presentation presentation NN cord-015306-us58wwmp 1355 27 of of IN cord-015306-us58wwmp 1355 28 HLA HLA NNP cord-015306-us58wwmp 1355 29 - - HYPH cord-015306-us58wwmp 1355 30 I -PRON- PRP cord-015306-us58wwmp 1355 31 restricted restrict VBD cord-015306-us58wwmp 1355 32 peptides peptide NNS cord-015306-us58wwmp 1355 33 . . . cord-015306-us58wwmp 1356 1 In in IN cord-015306-us58wwmp 1356 2 immune immune JJ cord-015306-us58wwmp 1356 3 mature mature JJ cord-015306-us58wwmp 1356 4 cells cell NNS cord-015306-us58wwmp 1356 5 , , , cord-015306-us58wwmp 1356 6 particularly particularly RB cord-015306-us58wwmp 1356 7 dendritic dendritic JJ cord-015306-us58wwmp 1356 8 cells cell NNS cord-015306-us58wwmp 1356 9 , , , cord-015306-us58wwmp 1356 10 the the DT cord-015306-us58wwmp 1356 11 PS PS NNP cord-015306-us58wwmp 1356 12 , , , cord-015306-us58wwmp 1356 13 under under IN cord-015306-us58wwmp 1356 14 the the DT cord-015306-us58wwmp 1356 15 action action NN cord-015306-us58wwmp 1356 16 of of IN cord-015306-us58wwmp 1356 17 interferon interferon NN cord-015306-us58wwmp 1356 18 gamma gamma NN cord-015306-us58wwmp 1356 19 and and CC cord-015306-us58wwmp 1356 20 alpha alpha NN cord-015306-us58wwmp 1356 21 , , , cord-015306-us58wwmp 1356 22 becomes become VBZ cord-015306-us58wwmp 1356 23 an an DT cord-015306-us58wwmp 1356 24 immunoproteasome immunoproteasome NN cord-015306-us58wwmp 1356 25 ( ( -LRB- cord-015306-us58wwmp 1356 26 iPS iPS NNP cord-015306-us58wwmp 1356 27 ) ) -RRB- cord-015306-us58wwmp 1356 28 , , , cord-015306-us58wwmp 1356 29 by by IN cord-015306-us58wwmp 1356 30 substituting substitute VBG cord-015306-us58wwmp 1356 31 3 3 CD cord-015306-us58wwmp 1356 32 catalytic catalytic JJ cord-015306-us58wwmp 1356 33 units unit NNS cord-015306-us58wwmp 1356 34 beta1 beta1 NN cord-015306-us58wwmp 1356 35 , , , cord-015306-us58wwmp 1356 36 beta2 beta2 NN cord-015306-us58wwmp 1356 37 , , , cord-015306-us58wwmp 1356 38 beta5 beta5 NN cord-015306-us58wwmp 1356 39 with with IN cord-015306-us58wwmp 1356 40 other other JJ cord-015306-us58wwmp 1356 41 low low JJ cord-015306-us58wwmp 1356 42 molecular molecular JJ cord-015306-us58wwmp 1356 43 weight weight NN cord-015306-us58wwmp 1356 44 proteins protein NNS cord-015306-us58wwmp 1356 45 ( ( -LRB- cord-015306-us58wwmp 1356 46 LMP2 lmp2 VB cord-015306-us58wwmp 1356 47 and and CC cord-015306-us58wwmp 1356 48 LMP7 LMP7 NNP cord-015306-us58wwmp 1356 49 ) ) -RRB- cord-015306-us58wwmp 1356 50 and and CC cord-015306-us58wwmp 1356 51 an an DT cord-015306-us58wwmp 1356 52 endopeptidase endopeptidase NN cord-015306-us58wwmp 1356 53 - - HYPH cord-015306-us58wwmp 1356 54 like like JJ cord-015306-us58wwmp 1356 55 complex complex NN cord-015306-us58wwmp 1356 56 ( ( -LRB- cord-015306-us58wwmp 1356 57 MECL-1 MECL-1 NNP cord-015306-us58wwmp 1356 58 ) ) -RRB- cord-015306-us58wwmp 1356 59 . . . cord-015306-us58wwmp 1357 1 This this DT cord-015306-us58wwmp 1357 2 modification modification NN cord-015306-us58wwmp 1357 3 confers confer VBZ cord-015306-us58wwmp 1357 4 an an DT cord-015306-us58wwmp 1357 5 optimal optimal JJ cord-015306-us58wwmp 1357 6 catalytic catalytic JJ cord-015306-us58wwmp 1357 7 property property NN cord-015306-us58wwmp 1357 8 for for IN cord-015306-us58wwmp 1357 9 professional professional JJ cord-015306-us58wwmp 1357 10 presentation presentation NN cord-015306-us58wwmp 1357 11 of of IN cord-015306-us58wwmp 1357 12 specific specific JJ cord-015306-us58wwmp 1357 13 peptides peptide NNS cord-015306-us58wwmp 1357 14 to to IN cord-015306-us58wwmp 1357 15 MHC MHC NNP cord-015306-us58wwmp 1357 16 Class Class NNP cord-015306-us58wwmp 1357 17 I. i. NN cord-015306-us58wwmp 1358 1 Our -PRON- PRP$ cord-015306-us58wwmp 1358 2 group group NN cord-015306-us58wwmp 1358 3 previously previously RB cord-015306-us58wwmp 1358 4 demonstrated demonstrate VBD cord-015306-us58wwmp 1358 5 that that IN cord-015306-us58wwmp 1358 6 adult adult NN cord-015306-us58wwmp 1358 7 patients patient NNS cord-015306-us58wwmp 1358 8 with with IN cord-015306-us58wwmp 1358 9 IgA IgA NNP cord-015306-us58wwmp 1358 10 - - HYPH cord-015306-us58wwmp 1358 11 Nephropathy Nephropathy NNP cord-015306-us58wwmp 1358 12 ( ( -LRB- cord-015306-us58wwmp 1358 13 IgAN IgAN NNP cord-015306-us58wwmp 1358 14 ) ) -RRB- cord-015306-us58wwmp 1358 15 have have VBP cord-015306-us58wwmp 1358 16 an an DT cord-015306-us58wwmp 1358 17 increased increase VBN cord-015306-us58wwmp 1358 18 expression expression NN cord-015306-us58wwmp 1358 19 of of IN cord-015306-us58wwmp 1358 20 iPS ips NN cord-015306-us58wwmp 1358 21 catalytic catalytic JJ cord-015306-us58wwmp 1358 22 subunit subunit NN cord-015306-us58wwmp 1358 23 , , , cord-015306-us58wwmp 1358 24 which which WDT cord-015306-us58wwmp 1358 25 correlated correlate VBD cord-015306-us58wwmp 1358 26 with with IN cord-015306-us58wwmp 1358 27 the the DT cord-015306-us58wwmp 1358 28 severity severity NN cord-015306-us58wwmp 1358 29 of of IN cord-015306-us58wwmp 1358 30 renal renal JJ cord-015306-us58wwmp 1358 31 disease disease NN cord-015306-us58wwmp 1358 32 . . . cord-015306-us58wwmp 1359 1 Aim aim VB cord-015306-us58wwmp 1359 2 of of IN cord-015306-us58wwmp 1359 3 this this DT cord-015306-us58wwmp 1359 4 study study NN cord-015306-us58wwmp 1359 5 was be VBD cord-015306-us58wwmp 1359 6 to to TO cord-015306-us58wwmp 1359 7 investigate investigate VB cord-015306-us58wwmp 1359 8 the the DT cord-015306-us58wwmp 1359 9 switch switch NN cord-015306-us58wwmp 1359 10 from from IN cord-015306-us58wwmp 1359 11 PS PS NNP cord-015306-us58wwmp 1359 12 to to IN cord-015306-us58wwmp 1359 13 iPS ip NNS cord-015306-us58wwmp 1359 14 in in IN cord-015306-us58wwmp 1359 15 children child NNS cord-015306-us58wwmp 1359 16 with with IN cord-015306-us58wwmp 1359 17 primary primary JJ cord-015306-us58wwmp 1359 18 IgAN IgAN NNP cord-015306-us58wwmp 1359 19 and and CC cord-015306-us58wwmp 1359 20 with with IN cord-015306-us58wwmp 1359 21 Henoch Henoch NNP cord-015306-us58wwmp 1359 22 - - HYPH cord-015306-us58wwmp 1359 23 Schoenlein Schoenlein NNP cord-015306-us58wwmp 1359 24 purpura purpura NN cord-015306-us58wwmp 1359 25 ( ( -LRB- cord-015306-us58wwmp 1359 26 HSP HSP NNP cord-015306-us58wwmp 1359 27 ) ) -RRB- cord-015306-us58wwmp 1359 28 , , , cord-015306-us58wwmp 1359 29 a a DT cord-015306-us58wwmp 1359 30 vasculitis vasculitis NN cord-015306-us58wwmp 1359 31 sharing sharing NN cord-015306-us58wwmp 1359 32 with with IN cord-015306-us58wwmp 1359 33 IgAN IgAN NNP cord-015306-us58wwmp 1359 34 several several JJ cord-015306-us58wwmp 1359 35 immune immune JJ cord-015306-us58wwmp 1359 36 system system NN cord-015306-us58wwmp 1359 37 abnormalities abnormality NNS cord-015306-us58wwmp 1359 38 . . . cord-015306-us58wwmp 1360 1 Methods method NNS cord-015306-us58wwmp 1360 2 : : : cord-015306-us58wwmp 1360 3 Peripheral Peripheral NNP cord-015306-us58wwmp 1360 4 Lymphomonocytes Lymphomonocytes NNP cord-015306-us58wwmp 1360 5 ( ( -LRB- cord-015306-us58wwmp 1360 6 PBMC PBMC NNP cord-015306-us58wwmp 1360 7 ) ) -RRB- cord-015306-us58wwmp 1360 8 from from IN cord-015306-us58wwmp 1360 9 18 18 CD cord-015306-us58wwmp 1360 10 children child NNS cord-015306-us58wwmp 1360 11 with with IN cord-015306-us58wwmp 1360 12 IgAN IgAN NNP cord-015306-us58wwmp 1360 13 , , , cord-015306-us58wwmp 1360 14 57 57 CD cord-015306-us58wwmp 1360 15 with with IN cord-015306-us58wwmp 1360 16 HSP HSP NNP cord-015306-us58wwmp 1360 17 and and CC cord-015306-us58wwmp 1360 18 33 33 CD cord-015306-us58wwmp 1360 19 healthy healthy JJ cord-015306-us58wwmp 1360 20 control control NN cord-015306-us58wwmp 1360 21 subjects subject NNS cord-015306-us58wwmp 1360 22 ( ( -LRB- cord-015306-us58wwmp 1360 23 HC HC NNP cord-015306-us58wwmp 1360 24 ) ) -RRB- cord-015306-us58wwmp 1360 25 , , , cord-015306-us58wwmp 1360 26 isolated isolate VBN cord-015306-us58wwmp 1360 27 by by IN cord-015306-us58wwmp 1360 28 centrifugation centrifugation NN cord-015306-us58wwmp 1360 29 gradient gradient NN cord-015306-us58wwmp 1360 30 , , , cord-015306-us58wwmp 1360 31 were be VBD cord-015306-us58wwmp 1360 32 tested test VBN cord-015306-us58wwmp 1360 33 with with IN cord-015306-us58wwmp 1360 34 real real JJ cord-015306-us58wwmp 1360 35 time time NN cord-015306-us58wwmp 1360 36 PRC PRC NNP cord-015306-us58wwmp 1360 37 ( ( -LRB- cord-015306-us58wwmp 1360 38 Taqman Taqman NNP cord-015306-us58wwmp 1360 39 ) ) -RRB- cord-015306-us58wwmp 1360 40 to to TO cord-015306-us58wwmp 1360 41 assess assess VB cord-015306-us58wwmp 1360 42 quantitatively quantitatively RB cord-015306-us58wwmp 1360 43 the the DT cord-015306-us58wwmp 1360 44 mRNA mRNA NNP cord-015306-us58wwmp 1360 45 levels level NNS cord-015306-us58wwmp 1360 46 of of IN cord-015306-us58wwmp 1360 47 PS PS NNP cord-015306-us58wwmp 1360 48 alpha alpha NN cord-015306-us58wwmp 1360 49 subunit subunit NN cord-015306-us58wwmp 1360 50 ( ( -LRB- cord-015306-us58wwmp 1360 51 constitutive constitutive JJ cord-015306-us58wwmp 1360 52 ) ) -RRB- cord-015306-us58wwmp 1360 53 , , , cord-015306-us58wwmp 1360 54 of of IN cord-015306-us58wwmp 1360 55 the the DT cord-015306-us58wwmp 1360 56 active active JJ cord-015306-us58wwmp 1360 57 subunit subunit NN cord-015306-us58wwmp 1360 58 of of IN cord-015306-us58wwmp 1360 59 PS PS NNP cord-015306-us58wwmp 1360 60 ( ( -LRB- cord-015306-us58wwmp 1360 61 beta1 beta1 NN cord-015306-us58wwmp 1360 62 , , , cord-015306-us58wwmp 1360 63 beta2 beta2 NN cord-015306-us58wwmp 1360 64 , , , cord-015306-us58wwmp 1360 65 beta5 beta5 NN cord-015306-us58wwmp 1360 66 ) ) -RRB- cord-015306-us58wwmp 1360 67 and and CC cord-015306-us58wwmp 1360 68 of of IN cord-015306-us58wwmp 1360 69 iPS iPS NNP cord-015306-us58wwmp 1360 70 ( ( -LRB- cord-015306-us58wwmp 1360 71 LMP2 LMP2 NNP cord-015306-us58wwmp 1360 72 , , , cord-015306-us58wwmp 1360 73 LMP7 LMP7 NNP cord-015306-us58wwmp 1360 74 and and CC cord-015306-us58wwmp 1360 75 MECL-1 MECL-1 NNP cord-015306-us58wwmp 1360 76 ) ) -RRB- cord-015306-us58wwmp 1360 77 . . . cord-015306-us58wwmp 1361 1 Results result NNS cord-015306-us58wwmp 1361 2 : : : cord-015306-us58wwmp 1362 1 Objective objective NN cord-015306-us58wwmp 1362 2 : : : cord-015306-us58wwmp 1363 1 Recent recent JJ cord-015306-us58wwmp 1363 2 studies study NNS cord-015306-us58wwmp 1363 3 suggest suggest VBP cord-015306-us58wwmp 1363 4 that that IN cord-015306-us58wwmp 1363 5 dysregulated dysregulate VBN cord-015306-us58wwmp 1363 6 innate innate JJ cord-015306-us58wwmp 1363 7 immunity immunity NN cord-015306-us58wwmp 1363 8 plays play VBZ cord-015306-us58wwmp 1363 9 an an DT cord-015306-us58wwmp 1363 10 important important JJ cord-015306-us58wwmp 1363 11 role role NN cord-015306-us58wwmp 1363 12 in in IN cord-015306-us58wwmp 1363 13 the the DT cord-015306-us58wwmp 1363 14 pathogenesis pathogenesis NN cord-015306-us58wwmp 1363 15 of of IN cord-015306-us58wwmp 1363 16 IgAnephropathy IgAnephropathy NNP cord-015306-us58wwmp 1363 17 ( ( -LRB- cord-015306-us58wwmp 1363 18 IgAN IgAN NNP cord-015306-us58wwmp 1363 19 ) ) -RRB- cord-015306-us58wwmp 1363 20 . . . cord-015306-us58wwmp 1364 1 Interleukin-20 interleukin-20 PRP cord-015306-us58wwmp 1364 2 subfamily subfamily NN cord-015306-us58wwmp 1364 3 and and CC cord-015306-us58wwmp 1364 4 its -PRON- PRP$ cord-015306-us58wwmp 1364 5 receptor receptor NN cord-015306-us58wwmp 1364 6 , , , cord-015306-us58wwmp 1364 7 interleukin-22 interleukin-22 NN cord-015306-us58wwmp 1364 8 receptor receptor NN cord-015306-us58wwmp 1364 9 alpha-1 alpha-1 NNP cord-015306-us58wwmp 1364 10 ( ( -LRB- cord-015306-us58wwmp 1364 11 IL-22R1 IL-22R1 NNS cord-015306-us58wwmp 1364 12 ) ) -RRB- cord-015306-us58wwmp 1364 13 , , , cord-015306-us58wwmp 1364 14 were be VBD cord-015306-us58wwmp 1364 15 recently recently RB cord-015306-us58wwmp 1364 16 identified identify VBN cord-015306-us58wwmp 1364 17 as as IN cord-015306-us58wwmp 1364 18 immunomodulators immunomodulator NNS cord-015306-us58wwmp 1364 19 in in IN cord-015306-us58wwmp 1364 20 human human JJ cord-015306-us58wwmp 1364 21 diseases disease NNS cord-015306-us58wwmp 1364 22 , , , cord-015306-us58wwmp 1364 23 acting act VBG cord-015306-us58wwmp 1364 24 as as IN cord-015306-us58wwmp 1364 25 mediators mediator NNS cord-015306-us58wwmp 1364 26 of of IN cord-015306-us58wwmp 1364 27 mucosal mucosal JJ cord-015306-us58wwmp 1364 28 host host NN cord-015306-us58wwmp 1364 29 defense defense NN cord-015306-us58wwmp 1364 30 . . . cord-015306-us58wwmp 1365 1 However however RB cord-015306-us58wwmp 1365 2 , , , cord-015306-us58wwmp 1365 3 the the DT cord-015306-us58wwmp 1365 4 potential potential JJ cord-015306-us58wwmp 1365 5 role role NN cord-015306-us58wwmp 1365 6 of of IN cord-015306-us58wwmp 1365 7 IL-22R1 IL-22R1 NNS cord-015306-us58wwmp 1365 8 in in IN cord-015306-us58wwmp 1365 9 the the DT cord-015306-us58wwmp 1365 10 pathogenesis pathogenesis NN cord-015306-us58wwmp 1365 11 of of IN cord-015306-us58wwmp 1365 12 IgAN IgAN NNP cord-015306-us58wwmp 1365 13 has have VBZ cord-015306-us58wwmp 1365 14 not not RB cord-015306-us58wwmp 1365 15 been be VBN cord-015306-us58wwmp 1365 16 explored explore VBN cord-015306-us58wwmp 1365 17 . . . cord-015306-us58wwmp 1366 1 Methods method NNS cord-015306-us58wwmp 1366 2 : : : cord-015306-us58wwmp 1366 3 In in IN cord-015306-us58wwmp 1366 4 the the DT cord-015306-us58wwmp 1366 5 current current JJ cord-015306-us58wwmp 1366 6 study study NN cord-015306-us58wwmp 1366 7 , , , cord-015306-us58wwmp 1366 8 one one CD cord-015306-us58wwmp 1366 9 hundred hundred CD cord-015306-us58wwmp 1366 10 ninety ninety CD cord-015306-us58wwmp 1366 11 four four CD cord-015306-us58wwmp 1366 12 patients patient NNS cord-015306-us58wwmp 1366 13 with with IN cord-015306-us58wwmp 1366 14 IgAN IgAN NNP cord-015306-us58wwmp 1366 15 and and CC cord-015306-us58wwmp 1366 16 287 287 CD cord-015306-us58wwmp 1366 17 normal normal JJ cord-015306-us58wwmp 1366 18 controls control NNS cord-015306-us58wwmp 1366 19 were be VBD cord-015306-us58wwmp 1366 20 genotyped genotype VBN cord-015306-us58wwmp 1366 21 for for IN cord-015306-us58wwmp 1366 22 coding code VBG cord-015306-us58wwmp 1366 23 polymorphisms polymorphism NNS cord-015306-us58wwmp 1366 24 of of IN cord-015306-us58wwmp 1366 25 the the DT cord-015306-us58wwmp 1366 26 IL-22R1 IL-22R1 NNS cord-015306-us58wwmp 1366 27 gene gene NN cord-015306-us58wwmp 1366 28 and and CC cord-015306-us58wwmp 1366 29 the the DT cord-015306-us58wwmp 1366 30 association association NN cord-015306-us58wwmp 1366 31 between between IN cord-015306-us58wwmp 1366 32 the the DT cord-015306-us58wwmp 1366 33 polymorphisms polymorphism NNS cord-015306-us58wwmp 1366 34 and and CC cord-015306-us58wwmp 1366 35 IgAN IgAN NNP cord-015306-us58wwmp 1366 36 was be VBD cord-015306-us58wwmp 1366 37 investigated investigate VBN cord-015306-us58wwmp 1366 38 . . . cord-015306-us58wwmp 1367 1 Local local JJ cord-015306-us58wwmp 1367 2 expression expression NN cord-015306-us58wwmp 1367 3 of of IN cord-015306-us58wwmp 1367 4 IL-22R1 IL-22R1 NNS cord-015306-us58wwmp 1367 5 was be VBD cord-015306-us58wwmp 1367 6 examined examine VBN cord-015306-us58wwmp 1367 7 in in IN cord-015306-us58wwmp 1367 8 patients patient NNS cord-015306-us58wwmp 1367 9 with with IN cord-015306-us58wwmp 1367 10 IgAN IgAN NNP cord-015306-us58wwmp 1367 11 and and CC cord-015306-us58wwmp 1367 12 healthy healthy JJ cord-015306-us58wwmp 1367 13 controls control NNS cord-015306-us58wwmp 1367 14 using use VBG cord-015306-us58wwmp 1367 15 immunohistochemistry immunohistochemistry NN cord-015306-us58wwmp 1367 16 . . . cord-015306-us58wwmp 1368 1 Results result NNS cord-015306-us58wwmp 1368 2 : : : cord-015306-us58wwmp 1369 1 Our -PRON- PRP$ cord-015306-us58wwmp 1369 2 case case NN cord-015306-us58wwmp 1369 3 - - HYPH cord-015306-us58wwmp 1369 4 control control NN cord-015306-us58wwmp 1369 5 analysis analysis NN cord-015306-us58wwmp 1369 6 showed show VBD cord-015306-us58wwmp 1369 7 that that IN cord-015306-us58wwmp 1369 8 genotypes genotype NNS cord-015306-us58wwmp 1369 9 of of IN cord-015306-us58wwmp 1369 10 rs3795299 rs3795299 NNP cord-015306-us58wwmp 1369 11 were be VBD cord-015306-us58wwmp 1369 12 associated associate VBN cord-015306-us58wwmp 1369 13 with with IN cord-015306-us58wwmp 1369 14 childhood childhood NN cord-015306-us58wwmp 1369 15 IgAN IgAN NNP cord-015306-us58wwmp 1369 16 . . . cord-015306-us58wwmp 1370 1 Individuals individual NNS cord-015306-us58wwmp 1370 2 with with IN cord-015306-us58wwmp 1370 3 the the DT cord-015306-us58wwmp 1370 4 CC CC NNP cord-015306-us58wwmp 1370 5 genotype genotype NN cord-015306-us58wwmp 1370 6 of of IN cord-015306-us58wwmp 1370 7 rs3795299 rs3795299 NNP cord-015306-us58wwmp 1370 8 had have VBD cord-015306-us58wwmp 1370 9 about about RB cord-015306-us58wwmp 1370 10 three three CD cord-015306-us58wwmp 1370 11 fold fold JJ cord-015306-us58wwmp 1370 12 reduced reduce VBN cord-015306-us58wwmp 1370 13 risk risk NN cord-015306-us58wwmp 1370 14 of of IN cord-015306-us58wwmp 1370 15 IgAN IgAN NNP cord-015306-us58wwmp 1370 16 compared compare VBN cord-015306-us58wwmp 1370 17 with with IN cord-015306-us58wwmp 1370 18 those those DT cord-015306-us58wwmp 1370 19 with with IN cord-015306-us58wwmp 1370 20 the the DT cord-015306-us58wwmp 1370 21 GG GG NNP cord-015306-us58wwmp 1370 22 genotype genotype NN cord-015306-us58wwmp 1370 23 in in IN cord-015306-us58wwmp 1370 24 the the DT cord-015306-us58wwmp 1370 25 codominant codominant JJ cord-015306-us58wwmp 1370 26 model model NN cord-015306-us58wwmp 1370 27 ( ( -LRB- cord-015306-us58wwmp 1370 28 p=0.0028 p=0.0028 NNP cord-015306-us58wwmp 1370 29 ) ) -RRB- cord-015306-us58wwmp 1370 30 and and CC cord-015306-us58wwmp 1370 31 those those DT cord-015306-us58wwmp 1370 32 with with IN cord-015306-us58wwmp 1370 33 the the DT cord-015306-us58wwmp 1370 34 genotypes genotype NNS cord-015306-us58wwmp 1370 35 containing contain VBG cord-015306-us58wwmp 1370 36 G g NN cord-015306-us58wwmp 1370 37 allele allele NN cord-015306-us58wwmp 1370 38 ( ( -LRB- cord-015306-us58wwmp 1370 39 GG GG NNP cord-015306-us58wwmp 1370 40 or or CC cord-015306-us58wwmp 1370 41 GC GC NNP cord-015306-us58wwmp 1370 42 ) ) -RRB- cord-015306-us58wwmp 1370 43 in in IN cord-015306-us58wwmp 1370 44 the the DT cord-015306-us58wwmp 1370 45 recessive recessive JJ cord-015306-us58wwmp 1370 46 model model NN cord-015306-us58wwmp 1370 47 ( ( -LRB- cord-015306-us58wwmp 1370 48 p=0.002).After p=0.002).after NN cord-015306-us58wwmp 1370 49 Bonferroni Bonferroni NNP cord-015306-us58wwmp 1370 50 correction correction NN cord-015306-us58wwmp 1370 51 , , , cord-015306-us58wwmp 1370 52 the the DT cord-015306-us58wwmp 1370 53 association association NN cord-015306-us58wwmp 1370 54 between between IN cord-015306-us58wwmp 1370 55 rs3795299 rs3795299 NNP cord-015306-us58wwmp 1370 56 CC CC NNP cord-015306-us58wwmp 1370 57 genotype genotype NN cord-015306-us58wwmp 1370 58 and and CC cord-015306-us58wwmp 1370 59 reduced reduce VBN cord-015306-us58wwmp 1370 60 risk risk NN cord-015306-us58wwmp 1370 61 of of IN cord-015306-us58wwmp 1370 62 developing develop VBG cord-015306-us58wwmp 1370 63 IgAN IgAN NNP cord-015306-us58wwmp 1370 64 remained remain VBD cord-015306-us58wwmp 1370 65 significant significant JJ cord-015306-us58wwmp 1370 66 . . . cord-015306-us58wwmp 1371 1 Furthermore furthermore RB cord-015306-us58wwmp 1371 2 , , , cord-015306-us58wwmp 1371 3 the the DT cord-015306-us58wwmp 1371 4 renal renal JJ cord-015306-us58wwmp 1371 5 expression expression NN cord-015306-us58wwmp 1371 6 of of IN cord-015306-us58wwmp 1371 7 IL-22R1 IL-22R1 NNS cord-015306-us58wwmp 1371 8 was be VBD cord-015306-us58wwmp 1371 9 significantly significantly RB cord-015306-us58wwmp 1371 10 higher high JJR cord-015306-us58wwmp 1371 11 in in IN cord-015306-us58wwmp 1371 12 healthy healthy JJ cord-015306-us58wwmp 1371 13 controls control NNS cord-015306-us58wwmp 1371 14 compared compare VBN cord-015306-us58wwmp 1371 15 with with IN cord-015306-us58wwmp 1371 16 subjects subject NNS cord-015306-us58wwmp 1371 17 with with IN cord-015306-us58wwmp 1371 18 IgAN IgAN NNP cord-015306-us58wwmp 1371 19 . . . cord-015306-us58wwmp 1372 1 Conclusion conclusion NN cord-015306-us58wwmp 1372 2 : : : cord-015306-us58wwmp 1373 1 Our -PRON- PRP$ cord-015306-us58wwmp 1373 2 data datum NNS cord-015306-us58wwmp 1373 3 suggest suggest VBP cord-015306-us58wwmp 1373 4 that that IN cord-015306-us58wwmp 1373 5 the the DT cord-015306-us58wwmp 1373 6 CC CC NNP cord-015306-us58wwmp 1373 7 genotype genotype NN cord-015306-us58wwmp 1373 8 of of IN cord-015306-us58wwmp 1373 9 rs3795299 rs3795299 NNP cord-015306-us58wwmp 1373 10 polymorphism polymorphism NN cord-015306-us58wwmp 1373 11 in in IN cord-015306-us58wwmp 1373 12 IL-22R1 IL-22R1 NNS cord-015306-us58wwmp 1373 13 gene gene NN cord-015306-us58wwmp 1373 14 is be VBZ cord-015306-us58wwmp 1373 15 associated associate VBN cord-015306-us58wwmp 1373 16 with with IN cord-015306-us58wwmp 1373 17 the the DT cord-015306-us58wwmp 1373 18 reduced reduce VBN cord-015306-us58wwmp 1373 19 risk risk NN cord-015306-us58wwmp 1373 20 of of IN cord-015306-us58wwmp 1373 21 IgAN IgAN NNP cord-015306-us58wwmp 1373 22 , , , cord-015306-us58wwmp 1373 23 and and CC cord-015306-us58wwmp 1373 24 this this DT cord-015306-us58wwmp 1373 25 genetic genetic JJ cord-015306-us58wwmp 1373 26 association association NN cord-015306-us58wwmp 1373 27 was be VBD cord-015306-us58wwmp 1373 28 supported support VBN cord-015306-us58wwmp 1373 29 by by IN cord-015306-us58wwmp 1373 30 the the DT cord-015306-us58wwmp 1373 31 higher high JJR cord-015306-us58wwmp 1373 32 renal renal JJ cord-015306-us58wwmp 1373 33 expression expression NN cord-015306-us58wwmp 1373 34 of of IN cord-015306-us58wwmp 1373 35 IL-22R1 IL-22R1 NNS cord-015306-us58wwmp 1373 36 in in IN cord-015306-us58wwmp 1373 37 healthy healthy JJ cord-015306-us58wwmp 1373 38 controls control NNS cord-015306-us58wwmp 1373 39 compared compare VBN cord-015306-us58wwmp 1373 40 with with IN cord-015306-us58wwmp 1373 41 patients patient NNS cord-015306-us58wwmp 1373 42 with with IN cord-015306-us58wwmp 1373 43 IgAN IgAN NNP cord-015306-us58wwmp 1373 44 . . . cord-015306-us58wwmp 1374 1 Abstract abstract JJ cord-015306-us58wwmp 1374 2 # # NN cord-015306-us58wwmp 1374 3 P p NN cord-015306-us58wwmp 1374 4 - - HYPH cord-015306-us58wwmp 1374 5 SAT168 SAT168 NNP cord-015306-us58wwmp 1374 6 Toll toll NN cord-015306-us58wwmp 1374 7 - - HYPH cord-015306-us58wwmp 1374 8 like like JJ cord-015306-us58wwmp 1374 9 receptor receptor NN cord-015306-us58wwmp 1374 10 9 9 CD cord-015306-us58wwmp 1374 11 gene gene NN cord-015306-us58wwmp 1374 12 polymorphisms polymorphism NNS cord-015306-us58wwmp 1374 13 contribute contribute VBP cord-015306-us58wwmp 1374 14 to to IN cord-015306-us58wwmp 1374 15 development development NN cord-015306-us58wwmp 1374 16 of of IN cord-015306-us58wwmp 1374 17 proteinuria proteinuria NN cord-015306-us58wwmp 1374 18 in in IN cord-015306-us58wwmp 1374 19 childhood childhood NN cord-015306-us58wwmp 1374 20 IgA IgA NNP cord-015306-us58wwmp 1374 21 nephropathy nephropathy NN cord-015306-us58wwmp 1374 22 Henoch Henoch NNP cord-015306-us58wwmp 1374 23 - - HYPH cord-015306-us58wwmp 1374 24 Schoenlein Schoenlein NNP cord-015306-us58wwmp 1374 25 purpura purpura NN cord-015306-us58wwmp 1374 26 ( ( -LRB- cord-015306-us58wwmp 1374 27 HSP HSP NNP cord-015306-us58wwmp 1374 28 ) ) -RRB- cord-015306-us58wwmp 1374 29 is be VBZ cord-015306-us58wwmp 1374 30 the the DT cord-015306-us58wwmp 1374 31 most most RBS cord-015306-us58wwmp 1374 32 common common JJ cord-015306-us58wwmp 1374 33 form form NN cord-015306-us58wwmp 1374 34 of of IN cord-015306-us58wwmp 1374 35 immune immune NN cord-015306-us58wwmp 1374 36 - - HYPH cord-015306-us58wwmp 1374 37 mediated mediate VBN cord-015306-us58wwmp 1374 38 systemic systemic JJ cord-015306-us58wwmp 1374 39 vasculitis vasculitis NN cord-015306-us58wwmp 1374 40 in in IN cord-015306-us58wwmp 1374 41 children child NNS cord-015306-us58wwmp 1374 42 , , , cord-015306-us58wwmp 1374 43 which which WDT cord-015306-us58wwmp 1374 44 mainly mainly RB cord-015306-us58wwmp 1374 45 affects affect VBZ cord-015306-us58wwmp 1374 46 skin skin NN cord-015306-us58wwmp 1374 47 , , , cord-015306-us58wwmp 1374 48 joints joint NNS cord-015306-us58wwmp 1374 49 , , , cord-015306-us58wwmp 1374 50 gastrointestinal gastrointestinal JJ cord-015306-us58wwmp 1374 51 tract tract NN cord-015306-us58wwmp 1374 52 and and CC cord-015306-us58wwmp 1374 53 kidney kidney NN cord-015306-us58wwmp 1374 54 . . . cord-015306-us58wwmp 1375 1 The the DT cord-015306-us58wwmp 1375 2 overall overall JJ cord-015306-us58wwmp 1375 3 prognosis prognosis NN cord-015306-us58wwmp 1375 4 of of IN cord-015306-us58wwmp 1375 5 HSP HSP NNP cord-015306-us58wwmp 1375 6 is be VBZ cord-015306-us58wwmp 1375 7 favorable favorable JJ cord-015306-us58wwmp 1375 8 , , , cord-015306-us58wwmp 1375 9 but but CC cord-015306-us58wwmp 1375 10 the the DT cord-015306-us58wwmp 1375 11 long long JJ cord-015306-us58wwmp 1375 12 - - HYPH cord-015306-us58wwmp 1375 13 term term NN cord-015306-us58wwmp 1375 14 outcome outcome NN cord-015306-us58wwmp 1375 15 is be VBZ cord-015306-us58wwmp 1375 16 dependent dependent JJ cord-015306-us58wwmp 1375 17 on on IN cord-015306-us58wwmp 1375 18 the the DT cord-015306-us58wwmp 1375 19 degree degree NN cord-015306-us58wwmp 1375 20 of of IN cord-015306-us58wwmp 1375 21 renal renal JJ cord-015306-us58wwmp 1375 22 involvement involvement NN cord-015306-us58wwmp 1375 23 . . . cord-015306-us58wwmp 1376 1 The the DT cord-015306-us58wwmp 1376 2 incidence incidence NN cord-015306-us58wwmp 1376 3 of of IN cord-015306-us58wwmp 1376 4 renal renal JJ cord-015306-us58wwmp 1376 5 involvement involvement NN cord-015306-us58wwmp 1376 6 varies vary VBZ cord-015306-us58wwmp 1376 7 from from IN cord-015306-us58wwmp 1376 8 20 20 CD cord-015306-us58wwmp 1376 9 to to TO cord-015306-us58wwmp 1376 10 60 60 CD cord-015306-us58wwmp 1376 11 % % NN cord-015306-us58wwmp 1376 12 and and CC cord-015306-us58wwmp 1376 13 there there EX cord-015306-us58wwmp 1376 14 have have VBP cord-015306-us58wwmp 1376 15 been be VBN cord-015306-us58wwmp 1376 16 some some DT cord-015306-us58wwmp 1376 17 reports report NNS cord-015306-us58wwmp 1376 18 showing show VBG cord-015306-us58wwmp 1376 19 that that IN cord-015306-us58wwmp 1376 20 nephritis nephritis NN cord-015306-us58wwmp 1376 21 might may MD cord-015306-us58wwmp 1376 22 be be VB cord-015306-us58wwmp 1376 23 related relate VBN cord-015306-us58wwmp 1376 24 to to IN cord-015306-us58wwmp 1376 25 an an DT cord-015306-us58wwmp 1376 26 older old JJR cord-015306-us58wwmp 1376 27 age age NN cord-015306-us58wwmp 1376 28 at at IN cord-015306-us58wwmp 1376 29 onset onset NN cord-015306-us58wwmp 1376 30 , , , cord-015306-us58wwmp 1376 31 persistent persistent JJ cord-015306-us58wwmp 1376 32 purpura purpura NN cord-015306-us58wwmp 1376 33 ( ( -LRB- cord-015306-us58wwmp 1376 34 > > NN cord-015306-us58wwmp 1376 35 1 1 CD cord-015306-us58wwmp 1376 36 month month NN cord-015306-us58wwmp 1376 37 ) ) -RRB- cord-015306-us58wwmp 1376 38 , , , cord-015306-us58wwmp 1376 39 severe severe JJ cord-015306-us58wwmp 1376 40 abdominal abdominal JJ cord-015306-us58wwmp 1376 41 pain pain NN cord-015306-us58wwmp 1376 42 , , , cord-015306-us58wwmp 1376 43 and and CC cord-015306-us58wwmp 1376 44 relapsing relapse VBG cord-015306-us58wwmp 1376 45 disease disease NN cord-015306-us58wwmp 1376 46 . . . cord-015306-us58wwmp 1377 1 Recently recently RB cord-015306-us58wwmp 1377 2 , , , cord-015306-us58wwmp 1377 3 several several JJ cord-015306-us58wwmp 1377 4 studies study NNS cord-015306-us58wwmp 1377 5 have have VBP cord-015306-us58wwmp 1377 6 shown show VBN cord-015306-us58wwmp 1377 7 that that IN cord-015306-us58wwmp 1377 8 galactose galactose NN cord-015306-us58wwmp 1377 9 - - HYPH cord-015306-us58wwmp 1377 10 deficient deficient JJ cord-015306-us58wwmp 1377 11 IgA1 iga1 ADD cord-015306-us58wwmp 1378 1 ( ( -LRB- cord-015306-us58wwmp 1378 2 Gd Gd NNP cord-015306-us58wwmp 1378 3 - - HYPH cord-015306-us58wwmp 1378 4 IgA1 IgA1 NNP cord-015306-us58wwmp 1378 5 ) ) -RRB- cord-015306-us58wwmp 1378 6 is be VBZ cord-015306-us58wwmp 1378 7 recognized recognize VBN cord-015306-us58wwmp 1378 8 by by IN cord-015306-us58wwmp 1378 9 anti anti JJ cord-015306-us58wwmp 1378 10 - - JJ cord-015306-us58wwmp 1378 11 glycan glycan JJ cord-015306-us58wwmp 1378 12 antibodies antibody NNS cord-015306-us58wwmp 1378 13 , , , cord-015306-us58wwmp 1378 14 resulting result VBG cord-015306-us58wwmp 1378 15 in in IN cord-015306-us58wwmp 1378 16 the the DT cord-015306-us58wwmp 1378 17 formation formation NN cord-015306-us58wwmp 1378 18 of of IN cord-015306-us58wwmp 1378 19 the the DT cord-015306-us58wwmp 1378 20 circulating circulate VBG cord-015306-us58wwmp 1378 21 immune immune JJ cord-015306-us58wwmp 1378 22 complexes complex NNS cord-015306-us58wwmp 1378 23 and and CC cord-015306-us58wwmp 1378 24 their -PRON- PRP$ cord-015306-us58wwmp 1378 25 mesangial mesangial JJ cord-015306-us58wwmp 1378 26 deposition deposition NN cord-015306-us58wwmp 1378 27 causing cause VBG cord-015306-us58wwmp 1378 28 renal renal JJ cord-015306-us58wwmp 1378 29 injury injury NN cord-015306-us58wwmp 1378 30 in in IN cord-015306-us58wwmp 1378 31 HSP HSP NNP cord-015306-us58wwmp 1378 32 nephritis nephritis NN cord-015306-us58wwmp 1378 33 and and CC cord-015306-us58wwmp 1378 34 serum serum NN cord-015306-us58wwmp 1378 35 galactose galactose NN cord-015306-us58wwmp 1378 36 - - HYPH cord-015306-us58wwmp 1378 37 deficient deficient JJ cord-015306-us58wwmp 1378 38 IgA1 iga1 CD cord-015306-us58wwmp 1378 39 levels level NNS cord-015306-us58wwmp 1378 40 were be VBD cord-015306-us58wwmp 1378 41 highly highly RB cord-015306-us58wwmp 1378 42 inherited inherit VBN cord-015306-us58wwmp 1378 43 in in IN cord-015306-us58wwmp 1378 44 children child NNS cord-015306-us58wwmp 1378 45 with with IN cord-015306-us58wwmp 1378 46 HSP HSP NNP cord-015306-us58wwmp 1378 47 nephritis nephritis NN cord-015306-us58wwmp 1378 48 . . . cord-015306-us58wwmp 1379 1 Regarding regard VBG cord-015306-us58wwmp 1379 2 the the DT cord-015306-us58wwmp 1379 3 treatment treatment NN cord-015306-us58wwmp 1379 4 of of IN cord-015306-us58wwmp 1379 5 HSP HSP NNP cord-015306-us58wwmp 1379 6 , , , cord-015306-us58wwmp 1379 7 one one CD cord-015306-us58wwmp 1379 8 randomized randomized JJ cord-015306-us58wwmp 1379 9 double double RB cord-015306-us58wwmp 1379 10 - - HYPH cord-015306-us58wwmp 1379 11 blinded blinded JJ cord-015306-us58wwmp 1379 12 controlled controlled JJ cord-015306-us58wwmp 1379 13 study study NN cord-015306-us58wwmp 1379 14 recently recently RB cord-015306-us58wwmp 1379 15 showed show VBD cord-015306-us58wwmp 1379 16 that that IN cord-015306-us58wwmp 1379 17 patients patient NNS cord-015306-us58wwmp 1379 18 with with IN cord-015306-us58wwmp 1379 19 abdiminal abdiminal JJ cord-015306-us58wwmp 1379 20 pain pain NN cord-015306-us58wwmp 1379 21 or or CC cord-015306-us58wwmp 1379 22 arthralgia arthralgia NNP cord-015306-us58wwmp 1379 23 may may MD cord-015306-us58wwmp 1379 24 benefit benefit VB cord-015306-us58wwmp 1379 25 from from IN cord-015306-us58wwmp 1379 26 early early JJ cord-015306-us58wwmp 1379 27 treatment treatment NN cord-015306-us58wwmp 1379 28 with with IN cord-015306-us58wwmp 1379 29 prednisone prednisone NNP cord-015306-us58wwmp 1379 30 , , , cord-015306-us58wwmp 1379 31 but but CC cord-015306-us58wwmp 1379 32 the the DT cord-015306-us58wwmp 1379 33 drug drug NN cord-015306-us58wwmp 1379 34 has have VBZ cord-015306-us58wwmp 1379 35 not not RB cord-015306-us58wwmp 1379 36 been be VBN cord-015306-us58wwmp 1379 37 proven prove VBN cord-015306-us58wwmp 1379 38 to to TO cord-015306-us58wwmp 1379 39 be be VB cord-015306-us58wwmp 1379 40 capable capable JJ cord-015306-us58wwmp 1379 41 of of IN cord-015306-us58wwmp 1379 42 preventing prevent VBG cord-015306-us58wwmp 1379 43 the the DT cord-015306-us58wwmp 1379 44 development development NN cord-015306-us58wwmp 1379 45 of of IN cord-015306-us58wwmp 1379 46 renal renal JJ cord-015306-us58wwmp 1379 47 symptoms symptom NNS cord-015306-us58wwmp 1379 48 . . . cord-015306-us58wwmp 1380 1 However however RB cord-015306-us58wwmp 1380 2 , , , cord-015306-us58wwmp 1380 3 it -PRON- PRP cord-015306-us58wwmp 1380 4 was be VBD cord-015306-us58wwmp 1380 5 effective effective JJ cord-015306-us58wwmp 1380 6 in in IN cord-015306-us58wwmp 1380 7 altering alter VBG cord-015306-us58wwmp 1380 8 the the DT cord-015306-us58wwmp 1380 9 course course NN cord-015306-us58wwmp 1380 10 of of IN cord-015306-us58wwmp 1380 11 renal renal JJ cord-015306-us58wwmp 1380 12 involvementMild involvementmild XX cord-015306-us58wwmp 1381 1 Henoch Henoch NNP cord-015306-us58wwmp 1381 2 - - HYPH cord-015306-us58wwmp 1381 3 Schoenlein Schoenlein NNP cord-015306-us58wwmp 1381 4 purpura purpura NN cord-015306-us58wwmp 1381 5 nephritis nephritis NN cord-015306-us58wwmp 1381 6 ( ( -LRB- cord-015306-us58wwmp 1381 7 HSPN HSPN NNP cord-015306-us58wwmp 1381 8 ) ) -RRB- cord-015306-us58wwmp 1381 9 generally generally RB cord-015306-us58wwmp 1381 10 does do VBZ cord-015306-us58wwmp 1381 11 not not RB cord-015306-us58wwmp 1381 12 require require VB cord-015306-us58wwmp 1381 13 aggressive aggressive JJ cord-015306-us58wwmp 1381 14 treatment treatment NN cord-015306-us58wwmp 1381 15 due due IN cord-015306-us58wwmp 1381 16 to to IN cord-015306-us58wwmp 1381 17 a a DT cord-015306-us58wwmp 1381 18 favorable favorable JJ cord-015306-us58wwmp 1381 19 course course NN cord-015306-us58wwmp 1381 20 of of IN cord-015306-us58wwmp 1381 21 the the DT cord-015306-us58wwmp 1381 22 disease disease NN cord-015306-us58wwmp 1381 23 , , , cord-015306-us58wwmp 1381 24 but but CC cord-015306-us58wwmp 1381 25 severe severe JJ cord-015306-us58wwmp 1381 26 nephritis nephritis NN cord-015306-us58wwmp 1381 27 has have VBZ cord-015306-us58wwmp 1381 28 a a DT cord-015306-us58wwmp 1381 29 high high JJ cord-015306-us58wwmp 1381 30 risk risk NN cord-015306-us58wwmp 1381 31 of of IN cord-015306-us58wwmp 1381 32 progression progression NN cord-015306-us58wwmp 1381 33 to to TO cord-015306-us58wwmp 1381 34 end end VB cord-015306-us58wwmp 1381 35 stage stage NN cord-015306-us58wwmp 1381 36 renal renal JJ cord-015306-us58wwmp 1381 37 failure failure NN cord-015306-us58wwmp 1381 38 . . . cord-015306-us58wwmp 1382 1 Although although IN cord-015306-us58wwmp 1382 2 several several JJ cord-015306-us58wwmp 1382 3 intensive intensive JJ cord-015306-us58wwmp 1382 4 therapies therapy NNS cord-015306-us58wwmp 1382 5 , , , cord-015306-us58wwmp 1382 6 such such JJ cord-015306-us58wwmp 1382 7 as as IN cord-015306-us58wwmp 1382 8 intravenous intravenous JJ cord-015306-us58wwmp 1382 9 high high JJ cord-015306-us58wwmp 1382 10 - - HYPH cord-015306-us58wwmp 1382 11 dose dose NN cord-015306-us58wwmp 1382 12 methylprednisolone methylprednisolone NN cord-015306-us58wwmp 1382 13 pulse pulse NN cord-015306-us58wwmp 1382 14 , , , cord-015306-us58wwmp 1382 15 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 1382 16 / / SYM cord-015306-us58wwmp 1382 17 cytotoxic cytotoxic JJ cord-015306-us58wwmp 1382 18 drugs drug NNS cord-015306-us58wwmp 1382 19 , , , cord-015306-us58wwmp 1382 20 fibrinolytic fibrinolytic JJ cord-015306-us58wwmp 1382 21 therapy therapy NN cord-015306-us58wwmp 1382 22 , , , cord-015306-us58wwmp 1382 23 anticoagulants anticoagulant NNS cord-015306-us58wwmp 1382 24 , , , cord-015306-us58wwmp 1382 25 antiplatelet antiplatelet NN cord-015306-us58wwmp 1382 26 agent agent NN cord-015306-us58wwmp 1382 27 and and CC cord-015306-us58wwmp 1382 28 plasma plasma NN cord-015306-us58wwmp 1382 29 exchange exchange NN cord-015306-us58wwmp 1382 30 , , , cord-015306-us58wwmp 1382 31 have have VBP cord-015306-us58wwmp 1382 32 been be VBN cord-015306-us58wwmp 1382 33 used use VBN cord-015306-us58wwmp 1382 34 in in IN cord-015306-us58wwmp 1382 35 children child NNS cord-015306-us58wwmp 1382 36 with with IN cord-015306-us58wwmp 1382 37 severe severe JJ cord-015306-us58wwmp 1382 38 HSPN HSPN NNP cord-015306-us58wwmp 1382 39 , , , cord-015306-us58wwmp 1382 40 treatment treatment NN cord-015306-us58wwmp 1382 41 of of IN cord-015306-us58wwmp 1382 42 HSPN HSPN NNP cord-015306-us58wwmp 1382 43 still still RB cord-015306-us58wwmp 1382 44 remains remain VBZ cord-015306-us58wwmp 1382 45 controversial controversial JJ cord-015306-us58wwmp 1382 46 due due IN cord-015306-us58wwmp 1382 47 to to IN cord-015306-us58wwmp 1382 48 the the DT cord-015306-us58wwmp 1382 49 rarity rarity NN cord-015306-us58wwmp 1382 50 of of IN cord-015306-us58wwmp 1382 51 randomized randomized JJ cord-015306-us58wwmp 1382 52 controlled control VBN cord-015306-us58wwmp 1382 53 studies study NNS cord-015306-us58wwmp 1382 54 in in IN cord-015306-us58wwmp 1382 55 this this DT cord-015306-us58wwmp 1382 56 field field NN cord-015306-us58wwmp 1382 57 . . . cord-015306-us58wwmp 1383 1 Expressions expression NNS cord-015306-us58wwmp 1383 2 and and CC cord-015306-us58wwmp 1383 3 significance significance NN cord-015306-us58wwmp 1383 4 of of IN cord-015306-us58wwmp 1383 5 mTOR mtor NN cord-015306-us58wwmp 1383 6 , , , cord-015306-us58wwmp 1383 7 p70S6K1 p70S6K1 NNP cord-015306-us58wwmp 1383 8 and and CC cord-015306-us58wwmp 1383 9 E e NN cord-015306-us58wwmp 1383 10 - - NN cord-015306-us58wwmp 1383 11 cadherin cadherin NN cord-015306-us58wwmp 1383 12 in in IN cord-015306-us58wwmp 1383 13 glomeruli glomerulus NNS cord-015306-us58wwmp 1383 14 of of IN cord-015306-us58wwmp 1383 15 children child NNS cord-015306-us58wwmp 1383 16 with with IN cord-015306-us58wwmp 1383 17 IgA IgA NNP cord-015306-us58wwmp 1383 18 nephropathy nephropathy NNP cord-015306-us58wwmp 1383 19 Objective Objective NNP cord-015306-us58wwmp 1383 20 : : : cord-015306-us58wwmp 1383 21 To to TO cord-015306-us58wwmp 1383 22 investigated investigate VBN cord-015306-us58wwmp 1383 23 the the DT cord-015306-us58wwmp 1383 24 expressions expression NNS cord-015306-us58wwmp 1383 25 of of IN cord-015306-us58wwmp 1383 26 mTOR mTOR NNP cord-015306-us58wwmp 1383 27 , , , cord-015306-us58wwmp 1383 28 p70S6K1 p70S6K1 NNP cord-015306-us58wwmp 1383 29 , , , cord-015306-us58wwmp 1383 30 and and CC cord-015306-us58wwmp 1383 31 E e NN cord-015306-us58wwmp 1383 32 - - NN cord-015306-us58wwmp 1383 33 cadherin cadherin NN cord-015306-us58wwmp 1383 34 in in IN cord-015306-us58wwmp 1383 35 glomeruli glomerulus NNS cord-015306-us58wwmp 1383 36 of of IN cord-015306-us58wwmp 1383 37 children child NNS cord-015306-us58wwmp 1383 38 with with IN cord-015306-us58wwmp 1383 39 IgAN IgAN NNP cord-015306-us58wwmp 1383 40 to to TO cord-015306-us58wwmp 1383 41 explore explore VB cord-015306-us58wwmp 1383 42 the the DT cord-015306-us58wwmp 1383 43 role role NN cord-015306-us58wwmp 1383 44 of of IN cord-015306-us58wwmp 1383 45 mTOR mTOR NNP cord-015306-us58wwmp 1383 46 / / SYM cord-015306-us58wwmp 1383 47 p70S6K1 p70S6K1 NNP cord-015306-us58wwmp 1383 48 signaling signal VBG cord-015306-us58wwmp 1383 49 pathway pathway NN cord-015306-us58wwmp 1383 50 in in IN cord-015306-us58wwmp 1383 51 the the DT cord-015306-us58wwmp 1383 52 progressive progressive JJ cord-015306-us58wwmp 1383 53 renal renal JJ cord-015306-us58wwmp 1383 54 glomeruli glomerulus NNS cord-015306-us58wwmp 1383 55 fibrosis fibrosis NN cord-015306-us58wwmp 1383 56 of of IN cord-015306-us58wwmp 1383 57 IgAN IgAN NNP cord-015306-us58wwmp 1383 58 . . . cord-015306-us58wwmp 1384 1 Methods method NNS cord-015306-us58wwmp 1384 2 : : : cord-015306-us58wwmp 1385 1 Seventy seventy CD cord-015306-us58wwmp 1385 2 - - HYPH cord-015306-us58wwmp 1385 3 two two CD cord-015306-us58wwmp 1385 4 children child NNS cord-015306-us58wwmp 1385 5 with with IN cord-015306-us58wwmp 1385 6 IgAN IgAN NNP cord-015306-us58wwmp 1385 7 were be VBD cord-015306-us58wwmp 1385 8 divided divide VBN cord-015306-us58wwmp 1385 9 into into IN cord-015306-us58wwmp 1385 10 three three CD cord-015306-us58wwmp 1385 11 groups group NNS cord-015306-us58wwmp 1385 12 according accord VBG cord-015306-us58wwmp 1385 13 to to IN cord-015306-us58wwmp 1385 14 their -PRON- PRP$ cord-015306-us58wwmp 1385 15 clinical clinical JJ cord-015306-us58wwmp 1385 16 features feature NNS cord-015306-us58wwmp 1385 17 : : : cord-015306-us58wwmp 1385 18 isolated isolate VBN cord-015306-us58wwmp 1385 19 hematuria hematuria NN cord-015306-us58wwmp 1385 20 group group NN cord-015306-us58wwmp 1385 21 ( ( -LRB- cord-015306-us58wwmp 1385 22 IH IH NNP cord-015306-us58wwmp 1385 23 group group NN cord-015306-us58wwmp 1385 24 , , , cord-015306-us58wwmp 1385 25 24 24 CD cord-015306-us58wwmp 1385 26 patients patient NNS cord-015306-us58wwmp 1385 27 ) ) -RRB- cord-015306-us58wwmp 1385 28 , , , cord-015306-us58wwmp 1385 29 hematuria hematuria NN cord-015306-us58wwmp 1385 30 and and CC cord-015306-us58wwmp 1385 31 proteinuria(HP proteinuria(HP NNP cord-015306-us58wwmp 1385 32 group group NN cord-015306-us58wwmp 1385 33 , , , cord-015306-us58wwmp 1385 34 26 26 CD cord-015306-us58wwmp 1385 35 patients patient NNS cord-015306-us58wwmp 1385 36 ) ) -RRB- cord-015306-us58wwmp 1385 37 , , , cord-015306-us58wwmp 1385 38 and and CC cord-015306-us58wwmp 1385 39 nephritic nephritic NNP cord-015306-us58wwmp 1385 40 syndrome syndrome NNP cord-015306-us58wwmp 1385 41 group group NN cord-015306-us58wwmp 1385 42 ( ( -LRB- cord-015306-us58wwmp 1385 43 NS NS NNP cord-015306-us58wwmp 1385 44 group group NN cord-015306-us58wwmp 1385 45 , , , cord-015306-us58wwmp 1385 46 22 22 CD cord-015306-us58wwmp 1385 47 patients patient NNS cord-015306-us58wwmp 1385 48 ) ) -RRB- cord-015306-us58wwmp 1385 49 . . . cord-015306-us58wwmp 1386 1 Patients patient NNS cord-015306-us58wwmp 1386 2 were be VBD cord-015306-us58wwmp 1386 3 also also RB cord-015306-us58wwmp 1386 4 also also RB cord-015306-us58wwmp 1386 5 divided divide VBN cord-015306-us58wwmp 1386 6 into into IN cord-015306-us58wwmp 1386 7 three three CD cord-015306-us58wwmp 1386 8 groups group NNS cord-015306-us58wwmp 1386 9 according accord VBG cord-015306-us58wwmp 1386 10 to to IN cord-015306-us58wwmp 1386 11 their -PRON- PRP$ cord-015306-us58wwmp 1386 12 pathologic pathologic JJ cord-015306-us58wwmp 1386 13 grades grade NNS cord-015306-us58wwmp 1386 14 : : : cord-015306-us58wwmp 1386 15 grade grade NN cord-015306-us58wwmp 1386 16 II(33 II(33 NNP cord-015306-us58wwmp 1386 17 patients patient NNS cord-015306-us58wwmp 1386 18 ) ) -RRB- cord-015306-us58wwmp 1386 19 , , , cord-015306-us58wwmp 1386 20 grade grade NN cord-015306-us58wwmp 1386 21 III(25 iii(25 CD cord-015306-us58wwmp 1386 22 patients patient NNS cord-015306-us58wwmp 1386 23 ) ) -RRB- cord-015306-us58wwmp 1386 24 and and CC cord-015306-us58wwmp 1386 25 grade grade NN cord-015306-us58wwmp 1386 26 IV(14 IV(14 '' cord-015306-us58wwmp 1386 27 patients patient NNS cord-015306-us58wwmp 1386 28 ) ) -RRB- cord-015306-us58wwmp 1386 29 . . . cord-015306-us58wwmp 1387 1 Six six CD cord-015306-us58wwmp 1387 2 normal normal JJ cord-015306-us58wwmp 1387 3 renal renal JJ cord-015306-us58wwmp 1387 4 specimens specimen NNS cord-015306-us58wwmp 1387 5 were be VBD cord-015306-us58wwmp 1387 6 used use VBN cord-015306-us58wwmp 1387 7 as as IN cord-015306-us58wwmp 1387 8 control control NN cord-015306-us58wwmp 1387 9 group group NN cord-015306-us58wwmp 1387 10 . . . cord-015306-us58wwmp 1388 1 The the DT cord-015306-us58wwmp 1388 2 expressions expression NNS cord-015306-us58wwmp 1388 3 of of IN cord-015306-us58wwmp 1388 4 mTOR mtor NN cord-015306-us58wwmp 1388 5 , , , cord-015306-us58wwmp 1388 6 p70S6K1 p70S6K1 NNP cord-015306-us58wwmp 1388 7 , , , cord-015306-us58wwmp 1388 8 and and CC cord-015306-us58wwmp 1388 9 E e NN cord-015306-us58wwmp 1388 10 - - NN cord-015306-us58wwmp 1388 11 cadherin cadherin NN cord-015306-us58wwmp 1388 12 in in IN cord-015306-us58wwmp 1388 13 glomeruli glomerulus NNS cord-015306-us58wwmp 1388 14 were be VBD cord-015306-us58wwmp 1388 15 determined determine VBN cord-015306-us58wwmp 1388 16 by by IN cord-015306-us58wwmp 1388 17 immunohistochemistry immunohistochemistry NN cord-015306-us58wwmp 1388 18 method method NN cord-015306-us58wwmp 1388 19 and and CC cord-015306-us58wwmp 1388 20 the the DT cord-015306-us58wwmp 1388 21 relationship relationship NN cord-015306-us58wwmp 1388 22 between between IN cord-015306-us58wwmp 1388 23 these these DT cord-015306-us58wwmp 1388 24 indexes index NNS cord-015306-us58wwmp 1388 25 and and CC cord-015306-us58wwmp 1388 26 the the DT cord-015306-us58wwmp 1388 27 clinical clinical JJ cord-015306-us58wwmp 1388 28 pathology pathology NN cord-015306-us58wwmp 1388 29 indexes index NNS cord-015306-us58wwmp 1388 30 were be VBD cord-015306-us58wwmp 1388 31 analyzed analyze VBN cord-015306-us58wwmp 1388 32 . . . cord-015306-us58wwmp 1389 1 Results result NNS cord-015306-us58wwmp 1389 2 : : : cord-015306-us58wwmp 1390 1 The the DT cord-015306-us58wwmp 1390 2 highest high JJS cord-015306-us58wwmp 1390 3 expressions expression NNS cord-015306-us58wwmp 1390 4 of of IN cord-015306-us58wwmp 1390 5 mTOR mTOR NNP cord-015306-us58wwmp 1390 6 and and CC cord-015306-us58wwmp 1390 7 p70S6K1 p70S6K1 NNP cord-015306-us58wwmp 1390 8 inglomeruli inglomeruli NNP cord-015306-us58wwmp 1390 9 were be VBD cord-015306-us58wwmp 1390 10 found find VBN cord-015306-us58wwmp 1390 11 in in IN cord-015306-us58wwmp 1390 12 the the DT cord-015306-us58wwmp 1390 13 NS NS NNP cord-015306-us58wwmp 1390 14 group group NN cord-015306-us58wwmp 1390 15 , , , cord-015306-us58wwmp 1390 16 both both DT cord-015306-us58wwmp 1390 17 of of IN cord-015306-us58wwmp 1390 18 which which WDT cord-015306-us58wwmp 1390 19 in in IN cord-015306-us58wwmp 1390 20 tubulointerstitium tubulointerstitium NN cord-015306-us58wwmp 1390 21 were be VBD cord-015306-us58wwmp 1390 22 higher high JJR cord-015306-us58wwmp 1390 23 in in IN cord-015306-us58wwmp 1390 24 grade grade NN cord-015306-us58wwmp 1390 25 III III NNP cord-015306-us58wwmp 1390 26 and and CC cord-015306-us58wwmp 1390 27 IV IV NNP cord-015306-us58wwmp 1390 28 group group NN cord-015306-us58wwmp 1390 29 than than IN cord-015306-us58wwmp 1390 30 that that DT cord-015306-us58wwmp 1390 31 in in IN cord-015306-us58wwmp 1390 32 grade grade NN cord-015306-us58wwmp 1390 33 II II NNP cord-015306-us58wwmp 1390 34 group group NN cord-015306-us58wwmp 1390 35 and and CC cord-015306-us58wwmp 1390 36 control control NN cord-015306-us58wwmp 1390 37 group group NN cord-015306-us58wwmp 1390 38 while while IN cord-015306-us58wwmp 1390 39 the the DT cord-015306-us58wwmp 1390 40 lowest low JJS cord-015306-us58wwmp 1390 41 expressions expression NNS cord-015306-us58wwmp 1390 42 of of IN cord-015306-us58wwmp 1390 43 E e NN cord-015306-us58wwmp 1390 44 - - NN cord-015306-us58wwmp 1390 45 cadherin cadherin NN cord-015306-us58wwmp 1390 46 was be VBD cord-015306-us58wwmp 1390 47 found find VBN cord-015306-us58wwmp 1390 48 in in IN cord-015306-us58wwmp 1390 49 the the DT cord-015306-us58wwmp 1390 50 grade grade NN cord-015306-us58wwmp 1390 51 IV IV NNP cord-015306-us58wwmp 1390 52 group group NN cord-015306-us58wwmp 1390 53 . . . cord-015306-us58wwmp 1391 1 The the DT cord-015306-us58wwmp 1391 2 glomerular glomerular JJ cord-015306-us58wwmp 1391 3 lesion lesion NN cord-015306-us58wwmp 1391 4 level level NN cord-015306-us58wwmp 1391 5 degree degree NN cord-015306-us58wwmp 1391 6 was be VBD cord-015306-us58wwmp 1391 7 positively positively RB cord-015306-us58wwmp 1391 8 correlated correlate VBN cord-015306-us58wwmp 1391 9 with with IN cord-015306-us58wwmp 1391 10 expressions expression NNS cord-015306-us58wwmp 1391 11 of of IN cord-015306-us58wwmp 1391 12 mTOR mTOR NNP cord-015306-us58wwmp 1391 13 and and CC cord-015306-us58wwmp 1391 14 p70S6K1 p70S6K1 NNP cord-015306-us58wwmp 1391 15 inglomeruli inglomeruli NNP cord-015306-us58wwmp 1391 16 . . . cord-015306-us58wwmp 1392 1 The the DT cord-015306-us58wwmp 1392 2 quantitative quantitative JJ cord-015306-us58wwmp 1392 3 urinary urinary JJ cord-015306-us58wwmp 1392 4 protein protein NN cord-015306-us58wwmp 1392 5 of of IN cord-015306-us58wwmp 1392 6 24 24 CD cord-015306-us58wwmp 1392 7 h h NNP cord-015306-us58wwmp 1392 8 was be VBD cord-015306-us58wwmp 1392 9 positively positively RB cord-015306-us58wwmp 1392 10 correlated correlate VBN cord-015306-us58wwmp 1392 11 with with IN cord-015306-us58wwmp 1392 12 expressionsss expressionss NNS cord-015306-us58wwmp 1392 13 of of IN cord-015306-us58wwmp 1392 14 mTOR mTOR NNP cord-015306-us58wwmp 1392 15 in in IN cord-015306-us58wwmp 1392 16 glomeruli glomeruli NNP cord-015306-us58wwmp 1392 17 . . . cord-015306-us58wwmp 1393 1 The the DT cord-015306-us58wwmp 1393 2 concentration concentration NN cord-015306-us58wwmp 1393 3 of of IN cord-015306-us58wwmp 1393 4 serum serum NN cord-015306-us58wwmp 1393 5 IgA IgA NNP cord-015306-us58wwmp 1393 6 was be VBD cord-015306-us58wwmp 1393 7 negatively negatively RB cord-015306-us58wwmp 1393 8 correlated correlate VBN cord-015306-us58wwmp 1393 9 with with IN cord-015306-us58wwmp 1393 10 the the DT cord-015306-us58wwmp 1393 11 expressionss expressionss NN cord-015306-us58wwmp 1393 12 level level NN cord-015306-us58wwmp 1393 13 of of IN cord-015306-us58wwmp 1393 14 mTOR mTOR NNP cord-015306-us58wwmp 1393 15 in in IN cord-015306-us58wwmp 1393 16 glomeruli glomeruli NNP cord-015306-us58wwmp 1393 17 . . . cord-015306-us58wwmp 1394 1 There there EX cord-015306-us58wwmp 1394 2 was be VBD cord-015306-us58wwmp 1394 3 no no DT cord-015306-us58wwmp 1394 4 significant significant JJ cord-015306-us58wwmp 1394 5 correlation correlation NN cord-015306-us58wwmp 1394 6 between between IN cord-015306-us58wwmp 1394 7 the the DT cord-015306-us58wwmp 1394 8 expressions expression NNS cord-015306-us58wwmp 1394 9 of of IN cord-015306-us58wwmp 1394 10 Ang Ang NNP cord-015306-us58wwmp 1394 11 II II NNP cord-015306-us58wwmp 1394 12 , , , cord-015306-us58wwmp 1394 13 mTOR mTOR NNP cord-015306-us58wwmp 1394 14 , , , cord-015306-us58wwmp 1394 15 p70S6K1 p70S6K1 NNP cord-015306-us58wwmp 1394 16 , , , cord-015306-us58wwmp 1394 17 E e NN cord-015306-us58wwmp 1394 18 - - NN cord-015306-us58wwmp 1394 19 cadherin cadherin NN cord-015306-us58wwmp 1394 20 and and CC cord-015306-us58wwmp 1394 21 α α NN cord-015306-us58wwmp 1394 22 - - HYPH cord-015306-us58wwmp 1394 23 SMA SMA NNP cord-015306-us58wwmp 1394 24 in in IN cord-015306-us58wwmp 1394 25 IgAN IgAN NNP cord-015306-us58wwmp 1394 26 glomeruli glomerulus NNS cord-015306-us58wwmp 1394 27 and and CC cord-015306-us58wwmp 1394 28 their -PRON- PRP$ cord-015306-us58wwmp 1394 29 courses course NNS cord-015306-us58wwmp 1394 30 from from IN cord-015306-us58wwmp 1394 31 duration duration NN cord-015306-us58wwmp 1394 32 of of IN cord-015306-us58wwmp 1394 33 illness illness NN cord-015306-us58wwmp 1394 34 as as RB cord-015306-us58wwmp 1394 35 well well RB cord-015306-us58wwmp 1394 36 as as IN cord-015306-us58wwmp 1394 37 IgA IgA NNP cord-015306-us58wwmp 1394 38 depositional depositional NNP cord-015306-us58wwmp 1394 39 strength strength NN cord-015306-us58wwmp 1394 40 . . . cord-015306-us58wwmp 1395 1 Conclusion conclusion NN cord-015306-us58wwmp 1395 2 : : : cord-015306-us58wwmp 1396 1 The the DT cord-015306-us58wwmp 1396 2 mTOR mtor NN cord-015306-us58wwmp 1396 3 / / SYM cord-015306-us58wwmp 1396 4 p70S6K1 p70S6K1 NNP cord-015306-us58wwmp 1396 5 signaling signal VBG cord-015306-us58wwmp 1396 6 pathway pathway NN cord-015306-us58wwmp 1396 7 was be VBD cord-015306-us58wwmp 1396 8 actived active VBN cord-015306-us58wwmp 1396 9 in in IN cord-015306-us58wwmp 1396 10 the the DT cord-015306-us58wwmp 1396 11 children child NNS cord-015306-us58wwmp 1396 12 with with IN cord-015306-us58wwmp 1396 13 IgAN IgAN NNP cord-015306-us58wwmp 1397 1 and and CC cord-015306-us58wwmp 1397 2 it -PRON- PRP cord-015306-us58wwmp 1397 3 may may MD cord-015306-us58wwmp 1397 4 play play VB cord-015306-us58wwmp 1397 5 an an DT cord-015306-us58wwmp 1397 6 important important JJ cord-015306-us58wwmp 1397 7 role role NN cord-015306-us58wwmp 1397 8 in in IN cord-015306-us58wwmp 1397 9 the the DT cord-015306-us58wwmp 1397 10 progress progress NN cord-015306-us58wwmp 1397 11 of of IN cord-015306-us58wwmp 1397 12 renal renal JJ cord-015306-us58wwmp 1397 13 glomeruli glomerulus NNS cord-015306-us58wwmp 1397 14 fibrosis fibrosis NN cord-015306-us58wwmp 1397 15 in in IN cord-015306-us58wwmp 1397 16 children child NNS cord-015306-us58wwmp 1397 17 with with IN cord-015306-us58wwmp 1397 18 IgAN IgAN NNP cord-015306-us58wwmp 1397 19 . . . cord-015306-us58wwmp 1398 1 Abstract abstract JJ cord-015306-us58wwmp 1398 2 # # NN cord-015306-us58wwmp 1399 1 P p NN cord-015306-us58wwmp 1399 2 - - HYPH cord-015306-us58wwmp 1399 3 SAT171 SAT171 NNP cord-015306-us58wwmp 1399 4 IgA1 iga1 RB cord-015306-us58wwmp 1399 5 from from IN cord-015306-us58wwmp 1399 6 HSP HSP NNP cord-015306-us58wwmp 1399 7 patients patient NNS cord-015306-us58wwmp 1399 8 trigger trigger VBP cord-015306-us58wwmp 1399 9 apoptosis apoptosis NN cord-015306-us58wwmp 1399 10 and and CC cord-015306-us58wwmp 1399 11 inhibit inhibit VB cord-015306-us58wwmp 1399 12 cytoskeletal cytoskeletal JJ cord-015306-us58wwmp 1399 13 proteins protein NNS cord-015306-us58wwmp 1399 14 in in IN cord-015306-us58wwmp 1399 15 HUVEC HUVEC NNP cord-015306-us58wwmp 1399 16 Objective Objective NNP cord-015306-us58wwmp 1399 17 : : : cord-015306-us58wwmp 1400 1 Henoch Henoch NNP cord-015306-us58wwmp 1400 2 - - HYPH cord-015306-us58wwmp 1400 3 Schonlein Schonlein NNP cord-015306-us58wwmp 1400 4 purpura purpura NN cord-015306-us58wwmp 1400 5 ( ( -LRB- cord-015306-us58wwmp 1400 6 HSP HSP NNP cord-015306-us58wwmp 1400 7 ) ) -RRB- cord-015306-us58wwmp 1400 8 is be VBZ cord-015306-us58wwmp 1400 9 the the DT cord-015306-us58wwmp 1400 10 most most RBS cord-015306-us58wwmp 1400 11 common common JJ cord-015306-us58wwmp 1400 12 form form NN cord-015306-us58wwmp 1400 13 of of IN cord-015306-us58wwmp 1400 14 small small JJ cord-015306-us58wwmp 1400 15 - - HYPH cord-015306-us58wwmp 1400 16 vessel vessel NN cord-015306-us58wwmp 1400 17 vasculitis vasculitis NN cord-015306-us58wwmp 1400 18 in in IN cord-015306-us58wwmp 1400 19 children child NNS cord-015306-us58wwmp 1400 20 , , , cord-015306-us58wwmp 1400 21 and and CC cord-015306-us58wwmp 1400 22 its -PRON- PRP$ cord-015306-us58wwmp 1400 23 etiology etiology NN cord-015306-us58wwmp 1400 24 is be VBZ cord-015306-us58wwmp 1400 25 believed believe VBN cord-015306-us58wwmp 1400 26 to to TO cord-015306-us58wwmp 1400 27 be be VB cord-015306-us58wwmp 1400 28 associated associate VBN cord-015306-us58wwmp 1400 29 with with IN cord-015306-us58wwmp 1400 30 immune immune JJ cord-015306-us58wwmp 1400 31 injury injury NN cord-015306-us58wwmp 1400 32 . . . cord-015306-us58wwmp 1401 1 A a DT cord-015306-us58wwmp 1401 2 polymorphism polymorphism NN cord-015306-us58wwmp 1401 3 in in IN cord-015306-us58wwmp 1401 4 the the DT cord-015306-us58wwmp 1401 5 gene gene NN cord-015306-us58wwmp 1401 6 encoding encode VBG cord-015306-us58wwmp 1401 7 heat heat NN cord-015306-us58wwmp 1401 8 shock shock NN cord-015306-us58wwmp 1401 9 protein protein NN cord-015306-us58wwmp 1401 10 70 70 CD cord-015306-us58wwmp 1401 11 - - HYPH cord-015306-us58wwmp 1401 12 2 2 CD cord-015306-us58wwmp 1401 13 ( ( -LRB- cord-015306-us58wwmp 1401 14 HSP70 HSP70 NNP cord-015306-us58wwmp 1401 15 - - HYPH cord-015306-us58wwmp 1401 16 2 2 NNP cord-015306-us58wwmp 1401 17 ) ) -RRB- cord-015306-us58wwmp 1401 18 is be VBZ cord-015306-us58wwmp 1401 19 known know VBN cord-015306-us58wwmp 1401 20 to to TO cord-015306-us58wwmp 1401 21 be be VB cord-015306-us58wwmp 1401 22 associated associate VBN cord-015306-us58wwmp 1401 23 with with IN cord-015306-us58wwmp 1401 24 immune immune JJ cord-015306-us58wwmp 1401 25 diseases disease NNS cord-015306-us58wwmp 1401 26 . . . cord-015306-us58wwmp 1402 1 The the DT cord-015306-us58wwmp 1402 2 purpose purpose NN cord-015306-us58wwmp 1402 3 of of IN cord-015306-us58wwmp 1402 4 this this DT cord-015306-us58wwmp 1402 5 study study NN cord-015306-us58wwmp 1402 6 was be VBD cord-015306-us58wwmp 1402 7 to to TO cord-015306-us58wwmp 1402 8 investigate investigate VB cord-015306-us58wwmp 1402 9 the the DT cord-015306-us58wwmp 1402 10 correlation correlation NN cord-015306-us58wwmp 1402 11 between between IN cord-015306-us58wwmp 1402 12 the the DT cord-015306-us58wwmp 1402 13 HSP70 HSP70 NNP cord-015306-us58wwmp 1402 14 - - HYPH cord-015306-us58wwmp 1402 15 2gene 2gene CD cord-015306-us58wwmp 1402 16 polymorphism polymorphism NN cord-015306-us58wwmp 1402 17 ( ( -LRB- cord-015306-us58wwmp 1402 18 + + CD cord-015306-us58wwmp 1402 19 1267 1267 CD cord-015306-us58wwmp 1402 20 A a NN cord-015306-us58wwmp 1402 21 / / SYM cord-015306-us58wwmp 1402 22 G G NNP cord-015306-us58wwmp 1402 23 ) ) -RRB- cord-015306-us58wwmp 1402 24 and and CC cord-015306-us58wwmp 1402 25 HSP HSP NNP cord-015306-us58wwmp 1402 26 in in IN cord-015306-us58wwmp 1402 27 children child NNS cord-015306-us58wwmp 1402 28 . . . cord-015306-us58wwmp 1403 1 The the DT cord-015306-us58wwmp 1403 2 polymerase polymerase NN cord-015306-us58wwmp 1403 3 chain chain NN cord-015306-us58wwmp 1403 4 reaction reaction NN cord-015306-us58wwmp 1403 5 - - HYPH cord-015306-us58wwmp 1403 6 restriction restriction NN cord-015306-us58wwmp 1403 7 fragment fragment NN cord-015306-us58wwmp 1403 8 length length NN cord-015306-us58wwmp 1403 9 polymorphism polymorphism NN cord-015306-us58wwmp 1403 10 ( ( -LRB- cord-015306-us58wwmp 1403 11 PCR PCR NNP cord-015306-us58wwmp 1403 12 - - HYPH cord-015306-us58wwmp 1403 13 RFLP RFLP NNP cord-015306-us58wwmp 1403 14 ) ) -RRB- cord-015306-us58wwmp 1403 15 method method NN cord-015306-us58wwmp 1403 16 was be VBD cord-015306-us58wwmp 1403 17 used use VBN cord-015306-us58wwmp 1403 18 to to TO cord-015306-us58wwmp 1403 19 detect detect VB cord-015306-us58wwmp 1403 20 the the DT cord-015306-us58wwmp 1403 21 HSP70 HSP70 NNP cord-015306-us58wwmp 1403 22 - - HYPH cord-015306-us58wwmp 1403 23 2 2 CD cord-015306-us58wwmp 1403 24 polymorphism polymorphism NN cord-015306-us58wwmp 1403 25 in in IN cord-015306-us58wwmp 1403 26 205 205 CD cord-015306-us58wwmp 1403 27 cases case NNS cord-015306-us58wwmp 1403 28 of of IN cord-015306-us58wwmp 1403 29 children child NNS cord-015306-us58wwmp 1403 30 with with IN cord-015306-us58wwmp 1403 31 HSP HSP NNP cord-015306-us58wwmp 1403 32 and and CC cord-015306-us58wwmp 1403 33 53 53 CD cord-015306-us58wwmp 1403 34 controls control NNS cord-015306-us58wwmp 1403 35 , , , cord-015306-us58wwmp 1403 36 and and CC cord-015306-us58wwmp 1403 37 the the DT cord-015306-us58wwmp 1403 38 association association NN cord-015306-us58wwmp 1403 39 of of IN cord-015306-us58wwmp 1403 40 this this DT cord-015306-us58wwmp 1403 41 polymorphism polymorphism NN cord-015306-us58wwmp 1403 42 with with IN cord-015306-us58wwmp 1403 43 HSP HSP NNP cord-015306-us58wwmp 1403 44 and and CC cord-015306-us58wwmp 1403 45 HSP HSP NNP cord-015306-us58wwmp 1403 46 nephritis nephritis NN cord-015306-us58wwmp 1403 47 ( ( -LRB- cord-015306-us58wwmp 1403 48 HSPN HSPN NNP cord-015306-us58wwmp 1403 49 ) ) -RRB- cord-015306-us58wwmp 1403 50 was be VBD cord-015306-us58wwmp 1403 51 analyzed analyze VBN cord-015306-us58wwmp 1403 52 . . . cord-015306-us58wwmp 1404 1 Results result NNS cord-015306-us58wwmp 1404 2 : : : cord-015306-us58wwmp 1405 1 In in IN cord-015306-us58wwmp 1405 2 patients patient NNS cord-015306-us58wwmp 1405 3 with with IN cord-015306-us58wwmp 1405 4 HSP HSP NNP cord-015306-us58wwmp 1405 5 , , , cord-015306-us58wwmp 1405 6 the the DT cord-015306-us58wwmp 1405 7 A A NNP cord-015306-us58wwmp 1405 8 / / SYM cord-015306-us58wwmp 1405 9 A A NNP cord-015306-us58wwmp 1405 10 , , , cord-015306-us58wwmp 1405 11 A A NNP cord-015306-us58wwmp 1405 12 / / SYM cord-015306-us58wwmp 1405 13 G g NN cord-015306-us58wwmp 1405 14 , , , cord-015306-us58wwmp 1405 15 and and CC cord-015306-us58wwmp 1405 16 G g NN cord-015306-us58wwmp 1405 17 / / SYM cord-015306-us58wwmp 1405 18 G g NN cord-015306-us58wwmp 1405 19 genotypic genotypic JJ cord-015306-us58wwmp 1405 20 frequencies frequency NNS cord-015306-us58wwmp 1405 21 at at IN cord-015306-us58wwmp 1405 22 the the DT cord-015306-us58wwmp 1405 23 +1267A +1267A NNP cord-015306-us58wwmp 1405 24 / / SYM cord-015306-us58wwmp 1405 25 G g NN cord-015306-us58wwmp 1405 26 position position NN cord-015306-us58wwmp 1405 27 of of IN cord-015306-us58wwmp 1405 28 HSP70 HSP70 NNP cord-015306-us58wwmp 1405 29 - - HYPH cord-015306-us58wwmp 1405 30 2 2 CD cord-015306-us58wwmp 1405 31 were be VBD cord-015306-us58wwmp 1405 32 25.9 25.9 CD cord-015306-us58wwmp 1405 33 % % NN cord-015306-us58wwmp 1405 34 , , , cord-015306-us58wwmp 1405 35 51.2 51.2 CD cord-015306-us58wwmp 1405 36 % % NN cord-015306-us58wwmp 1405 37 , , , cord-015306-us58wwmp 1405 38 and and CC cord-015306-us58wwmp 1405 39 22.9 22.9 CD cord-015306-us58wwmp 1405 40 % % NN cord-015306-us58wwmp 1405 41 , , , cord-015306-us58wwmp 1405 42 respectively respectively RB cord-015306-us58wwmp 1405 43 . . . cord-015306-us58wwmp 1406 1 In in IN cord-015306-us58wwmp 1406 2 the the DT cord-015306-us58wwmp 1406 3 control control NN cord-015306-us58wwmp 1406 4 group group NN cord-015306-us58wwmp 1406 5 , , , cord-015306-us58wwmp 1406 6 the the DT cord-015306-us58wwmp 1406 7 A A NNP cord-015306-us58wwmp 1406 8 / / SYM cord-015306-us58wwmp 1406 9 A A NNP cord-015306-us58wwmp 1406 10 , , , cord-015306-us58wwmp 1406 11 A A NNP cord-015306-us58wwmp 1406 12 / / SYM cord-015306-us58wwmp 1406 13 G g NN cord-015306-us58wwmp 1406 14 , , , cord-015306-us58wwmp 1406 15 and and CC cord-015306-us58wwmp 1406 16 G g NN cord-015306-us58wwmp 1406 17 / / SYM cord-015306-us58wwmp 1406 18 G g NN cord-015306-us58wwmp 1406 19 genotypic genotypic JJ cord-015306-us58wwmp 1406 20 frequencies frequency NNS cord-015306-us58wwmp 1406 21 at at IN cord-015306-us58wwmp 1406 22 the the DT cord-015306-us58wwmp 1406 23 +1267A +1267A NNP cord-015306-us58wwmp 1406 24 / / SYM cord-015306-us58wwmp 1406 25 G g NN cord-015306-us58wwmp 1406 26 position position NN cord-015306-us58wwmp 1406 27 of of IN cord-015306-us58wwmp 1406 28 HSP70 HSP70 NNP cord-015306-us58wwmp 1406 29 - - HYPH cord-015306-us58wwmp 1406 30 2 2 CD cord-015306-us58wwmp 1406 31 were be VBD cord-015306-us58wwmp 1406 32 30.2 30.2 CD cord-015306-us58wwmp 1406 33 % % NN cord-015306-us58wwmp 1406 34 , , , cord-015306-us58wwmp 1406 35 60.4 60.4 CD cord-015306-us58wwmp 1406 36 % % NN cord-015306-us58wwmp 1406 37 , , , cord-015306-us58wwmp 1406 38 and and CC cord-015306-us58wwmp 1406 39 9.4 9.4 CD cord-015306-us58wwmp 1406 40 % % NN cord-015306-us58wwmp 1406 41 , , , cord-015306-us58wwmp 1406 42 respectively respectively RB cord-015306-us58wwmp 1406 43 . . . cord-015306-us58wwmp 1407 1 Thus thus RB cord-015306-us58wwmp 1407 2 , , , cord-015306-us58wwmp 1407 3 the the DT cord-015306-us58wwmp 1407 4 G g NN cord-015306-us58wwmp 1407 5 / / SYM cord-015306-us58wwmp 1407 6 G g NN cord-015306-us58wwmp 1407 7 genotypic genotypic JJ cord-015306-us58wwmp 1407 8 frequency frequency NN cord-015306-us58wwmp 1407 9 in in IN cord-015306-us58wwmp 1407 10 the the DT cord-015306-us58wwmp 1407 11 HSP HSP NNP cord-015306-us58wwmp 1407 12 group group NN cord-015306-us58wwmp 1407 13 was be VBD cord-015306-us58wwmp 1407 14 significantly significantly RB cord-015306-us58wwmp 1407 15 higher high JJR cord-015306-us58wwmp 1407 16 than than IN cord-015306-us58wwmp 1407 17 that that DT cord-015306-us58wwmp 1407 18 in in IN cord-015306-us58wwmp 1407 19 the the DT cord-015306-us58wwmp 1407 20 healthy healthy JJ cord-015306-us58wwmp 1407 21 control control NN cord-015306-us58wwmp 1407 22 group group NN cord-015306-us58wwmp 1407 23 ( ( -LRB- cord-015306-us58wwmp 1407 24 χ2=4.764 χ2=4.764 NNP cord-015306-us58wwmp 1407 25 , , , cord-015306-us58wwmp 1407 26 p<0.05 p<0.05 CD cord-015306-us58wwmp 1407 27 ) ) -RRB- cord-015306-us58wwmp 1407 28 . . . cord-015306-us58wwmp 1408 1 The the DT cord-015306-us58wwmp 1408 2 frequencies frequency NNS cord-015306-us58wwmp 1408 3 of of IN cord-015306-us58wwmp 1408 4 the the DT cord-015306-us58wwmp 1408 5 A A NNP cord-015306-us58wwmp 1408 6 and and CC cord-015306-us58wwmp 1408 7 the the DT cord-015306-us58wwmp 1408 8 G g NN cord-015306-us58wwmp 1408 9 allele allele NN cord-015306-us58wwmp 1408 10 were be VBD cord-015306-us58wwmp 1408 11 51.5 51.5 CD cord-015306-us58wwmp 1408 12 % % NN cord-015306-us58wwmp 1408 13 and and CC cord-015306-us58wwmp 1408 14 48.5 48.5 CD cord-015306-us58wwmp 1408 15 % % NN cord-015306-us58wwmp 1408 16 , , , cord-015306-us58wwmp 1408 17 respectively respectively RB cord-015306-us58wwmp 1408 18 , , , cord-015306-us58wwmp 1408 19 in in IN cord-015306-us58wwmp 1408 20 the the DT cord-015306-us58wwmp 1408 21 HSP HSP NNP cord-015306-us58wwmp 1408 22 group group NN cord-015306-us58wwmp 1408 23 and and CC cord-015306-us58wwmp 1408 24 were be VBD cord-015306-us58wwmp 1408 25 60.4 60.4 CD cord-015306-us58wwmp 1408 26 % % NN cord-015306-us58wwmp 1408 27 and and CC cord-015306-us58wwmp 1408 28 39.6 39.6 CD cord-015306-us58wwmp 1408 29 % % NN cord-015306-us58wwmp 1408 30 , , , cord-015306-us58wwmp 1408 31 respectively respectively RB cord-015306-us58wwmp 1408 32 , , , cord-015306-us58wwmp 1408 33 in in IN cord-015306-us58wwmp 1408 34 the the DT cord-015306-us58wwmp 1408 35 control control NN cord-015306-us58wwmp 1408 36 group group NN cord-015306-us58wwmp 1408 37 . . . cord-015306-us58wwmp 1409 1 The the DT cord-015306-us58wwmp 1409 2 frequencies frequency NNS cord-015306-us58wwmp 1409 3 of of IN cord-015306-us58wwmp 1409 4 the the DT cord-015306-us58wwmp 1409 5 A A NNP cord-015306-us58wwmp 1409 6 / / SYM cord-015306-us58wwmp 1409 7 A A NNP cord-015306-us58wwmp 1409 8 , , , cord-015306-us58wwmp 1409 9 A A NNP cord-015306-us58wwmp 1409 10 / / SYM cord-015306-us58wwmp 1409 11 G g NN cord-015306-us58wwmp 1409 12 , , , cord-015306-us58wwmp 1409 13 and and CC cord-015306-us58wwmp 1409 14 G g NN cord-015306-us58wwmp 1409 15 / / SYM cord-015306-us58wwmp 1409 16 G g NN cord-015306-us58wwmp 1409 17 genotypes genotype NNS cord-015306-us58wwmp 1409 18 in in IN cord-015306-us58wwmp 1409 19 patients patient NNS cord-015306-us58wwmp 1409 20 with with IN cord-015306-us58wwmp 1409 21 HSP HSP NNP cord-015306-us58wwmp 1409 22 were be VBD cord-015306-us58wwmp 1409 23 24.8 24.8 CD cord-015306-us58wwmp 1409 24 % % NN cord-015306-us58wwmp 1409 25 , , , cord-015306-us58wwmp 1409 26 52.9 52.9 CD cord-015306-us58wwmp 1409 27 % % NN cord-015306-us58wwmp 1409 28 , , , cord-015306-us58wwmp 1409 29 and and CC cord-015306-us58wwmp 1409 30 22.3 22.3 CD cord-015306-us58wwmp 1409 31 % % NN cord-015306-us58wwmp 1409 32 , , , cord-015306-us58wwmp 1409 33 respectively respectively RB cord-015306-us58wwmp 1409 34 . . . cord-015306-us58wwmp 1410 1 In in IN cord-015306-us58wwmp 1410 2 HSPN HSPN NNP cord-015306-us58wwmp 1410 3 , , , cord-015306-us58wwmp 1410 4 the the DT cord-015306-us58wwmp 1410 5 frequencies frequency NNS cord-015306-us58wwmp 1410 6 of of IN cord-015306-us58wwmp 1410 7 the the DT cord-015306-us58wwmp 1410 8 A A NNP cord-015306-us58wwmp 1410 9 / / SYM cord-015306-us58wwmp 1410 10 A A NNP cord-015306-us58wwmp 1410 11 , , , cord-015306-us58wwmp 1410 12 A A NNP cord-015306-us58wwmp 1410 13 / / SYM cord-015306-us58wwmp 1410 14 G g NN cord-015306-us58wwmp 1410 15 , , , cord-015306-us58wwmp 1410 16 and and CC cord-015306-us58wwmp 1410 17 G g NN cord-015306-us58wwmp 1410 18 / / SYM cord-015306-us58wwmp 1410 19 G g NN cord-015306-us58wwmp 1410 20 genotype genotype NN cord-015306-us58wwmp 1410 21 were be VBD cord-015306-us58wwmp 1410 22 27.4 27.4 CD cord-015306-us58wwmp 1410 23 % % NN cord-015306-us58wwmp 1410 24 , , , cord-015306-us58wwmp 1410 25 48.8 48.8 CD cord-015306-us58wwmp 1410 26 % % NN cord-015306-us58wwmp 1410 27 , , , cord-015306-us58wwmp 1410 28 and and CC cord-015306-us58wwmp 1410 29 23.8 23.8 CD cord-015306-us58wwmp 1410 30 % % NN cord-015306-us58wwmp 1410 31 , , , cord-015306-us58wwmp 1410 32 respectively respectively RB cord-015306-us58wwmp 1410 33 . . . cord-015306-us58wwmp 1411 1 Conclusion conclusion NN cord-015306-us58wwmp 1411 2 : : : cord-015306-us58wwmp 1412 1 The the DT cord-015306-us58wwmp 1412 2 +1267A +1267a JJ cord-015306-us58wwmp 1412 3 / / SYM cord-015306-us58wwmp 1412 4 G g NN cord-015306-us58wwmp 1412 5 polymorphism polymorphism NN cord-015306-us58wwmp 1412 6 in in IN cord-015306-us58wwmp 1412 7 the the DT cord-015306-us58wwmp 1412 8 HSP70 HSP70 NNP cord-015306-us58wwmp 1412 9 - - HYPH cord-015306-us58wwmp 1412 10 2 2 CD cord-015306-us58wwmp 1412 11 gene gene NN cord-015306-us58wwmp 1412 12 is be VBZ cord-015306-us58wwmp 1412 13 associated associate VBN cord-015306-us58wwmp 1412 14 with with IN cord-015306-us58wwmp 1412 15 HSP HSP NNP cord-015306-us58wwmp 1412 16 in in IN cord-015306-us58wwmp 1412 17 children child NNS cord-015306-us58wwmp 1412 18 . . . cord-015306-us58wwmp 1413 1 The the DT cord-015306-us58wwmp 1413 2 G g NN cord-015306-us58wwmp 1413 3 / / SYM cord-015306-us58wwmp 1413 4 G g NN cord-015306-us58wwmp 1413 5 homozygous homozygous JJ cord-015306-us58wwmp 1413 6 genotype genotype NN cord-015306-us58wwmp 1413 7 may may MD cord-015306-us58wwmp 1413 8 be be VB cord-015306-us58wwmp 1413 9 a a DT cord-015306-us58wwmp 1413 10 genetic genetic JJ cord-015306-us58wwmp 1413 11 factor factor NN cord-015306-us58wwmp 1413 12 that that WDT cord-015306-us58wwmp 1413 13 predisposes predispose VBZ cord-015306-us58wwmp 1413 14 individuals individual NNS cord-015306-us58wwmp 1413 15 to to IN cord-015306-us58wwmp 1413 16 HSP HSP NNP cord-015306-us58wwmp 1413 17 , , , cord-015306-us58wwmp 1413 18 but but CC cord-015306-us58wwmp 1413 19 it -PRON- PRP cord-015306-us58wwmp 1413 20 is be VBZ cord-015306-us58wwmp 1413 21 not not RB cord-015306-us58wwmp 1413 22 significantly significantly RB cord-015306-us58wwmp 1413 23 associated associate VBN cord-015306-us58wwmp 1413 24 with with IN cord-015306-us58wwmp 1413 25 the the DT cord-015306-us58wwmp 1413 26 development development NN cord-015306-us58wwmp 1413 27 of of IN cord-015306-us58wwmp 1413 28 renal renal JJ cord-015306-us58wwmp 1413 29 impairment impairment NN cord-015306-us58wwmp 1413 30 . . . cord-015306-us58wwmp 1414 1 Abstract abstract JJ cord-015306-us58wwmp 1414 2 # # NN cord-015306-us58wwmp 1415 1 P p NN cord-015306-us58wwmp 1415 2 - - , cord-015306-us58wwmp 1415 3 SAT174 SAT174 NNP cord-015306-us58wwmp 1415 4 Investigation Investigation NNP cord-015306-us58wwmp 1415 5 of of IN cord-015306-us58wwmp 1415 6 the the DT cord-015306-us58wwmp 1415 7 correlation correlation NN cord-015306-us58wwmp 1415 8 between between IN cord-015306-us58wwmp 1415 9 tumor tumor NN cord-015306-us58wwmp 1415 10 necrosis necrosis NN cord-015306-us58wwmp 1415 11 factoralpha factoralpha NNP cord-015306-us58wwmp 1415 12 gene gene NN cord-015306-us58wwmp 1415 13 polymorphism polymorphism NN cord-015306-us58wwmp 1415 14 and and CC cord-015306-us58wwmp 1415 15 Henoch Henoch NNP cord-015306-us58wwmp 1415 16 - - HYPH cord-015306-us58wwmp 1415 17 Schonlein Schonlein NNP cord-015306-us58wwmp 1415 18 purpura purpura NN cord-015306-us58wwmp 1415 19 in in IN cord-015306-us58wwmp 1415 20 children child NNS cord-015306-us58wwmp 1415 21 Fei Fei NNP cord-015306-us58wwmp 1415 22 Zhao Zhao NNP cord-015306-us58wwmp 1415 23 1,2 1,2 CD cord-015306-us58wwmp 1415 24 , , , cord-015306-us58wwmp 1415 25 Songming Songming NNP cord-015306-us58wwmp 1415 26 Huang Huang NNP cord-015306-us58wwmp 1415 27 1 1 CD cord-015306-us58wwmp 1415 28 , , , cord-015306-us58wwmp 1415 29 2 2 CD cord-015306-us58wwmp 1415 30 , , , cord-015306-us58wwmp 1415 31 Huaying Huaying NNP cord-015306-us58wwmp 1415 32 Bao Bao NNP cord-015306-us58wwmp 1415 33 1 1 CD cord-015306-us58wwmp 1415 34 , , , cord-015306-us58wwmp 1415 35 Guixia Guixia NNP cord-015306-us58wwmp 1415 36 Ding Ding NNP cord-015306-us58wwmp 1415 37 1 1 CD cord-015306-us58wwmp 1415 38 , , , cord-015306-us58wwmp 1415 39 Ying Ying NNP cord-015306-us58wwmp 1415 40 Chen Chen NNP cord-015306-us58wwmp 1415 41 1 1 CD cord-015306-us58wwmp 1415 42 , , , cord-015306-us58wwmp 1415 43 Hongmei Hongmei NNP cord-015306-us58wwmp 1415 44 Wu Wu NNP cord-015306-us58wwmp 1415 45 1 1 CD cord-015306-us58wwmp 1415 46 , , , cord-015306-us58wwmp 1415 47 Aihua Aihua NNP cord-015306-us58wwmp 1415 48 Zhang Zhang NNP cord-015306-us58wwmp 1415 49 1 1 CD cord-015306-us58wwmp 1415 50 1 1 CD cord-015306-us58wwmp 1415 51 Nephrology Nephrology NNP cord-015306-us58wwmp 1415 52 , , , cord-015306-us58wwmp 1415 53 Nanjing Nanjing NNP cord-015306-us58wwmp 1415 54 Children Children NNPS cord-015306-us58wwmp 1415 55 's 's POS cord-015306-us58wwmp 1415 56 Hospital Hospital NNP cord-015306-us58wwmp 1415 57 , , , cord-015306-us58wwmp 1415 58 Nanjing Nanjing NNP cord-015306-us58wwmp 1415 59 , , , cord-015306-us58wwmp 1415 60 China China NNP cord-015306-us58wwmp 1415 61 2 2 CD cord-015306-us58wwmp 1415 62 Institute Institute NNP cord-015306-us58wwmp 1415 63 of of IN cord-015306-us58wwmp 1415 64 Pediatrics Pediatrics NNP cord-015306-us58wwmp 1415 65 , , , cord-015306-us58wwmp 1415 66 Nanjing Nanjing NNP cord-015306-us58wwmp 1415 67 Medical Medical NNP cord-015306-us58wwmp 1415 68 University University NNP cord-015306-us58wwmp 1415 69 , , , cord-015306-us58wwmp 1415 70 Nanjing Nanjing NNP cord-015306-us58wwmp 1415 71 , , , cord-015306-us58wwmp 1416 1 China China NNP cord-015306-us58wwmp 1416 2 Objective Objective NNP cord-015306-us58wwmp 1416 3 : : : cord-015306-us58wwmp 1416 4 To to TO cord-015306-us58wwmp 1416 5 investigate investigate VB cord-015306-us58wwmp 1416 6 the the DT cord-015306-us58wwmp 1416 7 association association NN cord-015306-us58wwmp 1416 8 between between IN cord-015306-us58wwmp 1416 9 serum serum NN cord-015306-us58wwmp 1416 10 tumor tumor NN cord-015306-us58wwmp 1416 11 necrosis necrosis NN cord-015306-us58wwmp 1416 12 factor factor NN cord-015306-us58wwmp 1416 13 - - HYPH cord-015306-us58wwmp 1416 14 α α NN cord-015306-us58wwmp 1416 15 ( ( -LRB- cord-015306-us58wwmp 1416 16 TNF TNF NNP cord-015306-us58wwmp 1416 17 - - HYPH cord-015306-us58wwmp 1416 18 α α NNP cord-015306-us58wwmp 1416 19 ) ) -RRB- cord-015306-us58wwmp 1416 20 gene gene NN cord-015306-us58wwmp 1416 21 polymorphism polymorphism NN cord-015306-us58wwmp 1416 22 and and CC cord-015306-us58wwmp 1416 23 the the DT cord-015306-us58wwmp 1416 24 occurrence occurrence NN cord-015306-us58wwmp 1416 25 and and CC cord-015306-us58wwmp 1416 26 development development NN cord-015306-us58wwmp 1416 27 of of IN cord-015306-us58wwmp 1416 28 Henoch Henoch NNP cord-015306-us58wwmp 1416 29 - - HYPH cord-015306-us58wwmp 1416 30 Schoenlein Schoenlein NNP cord-015306-us58wwmp 1416 31 purpura purpura NN cord-015306-us58wwmp 1416 32 ( ( -LRB- cord-015306-us58wwmp 1416 33 HSP HSP NNP cord-015306-us58wwmp 1416 34 ) ) -RRB- cord-015306-us58wwmp 1416 35 in in IN cord-015306-us58wwmp 1416 36 children child NNS cord-015306-us58wwmp 1416 37 . . . cord-015306-us58wwmp 1417 1 The the DT cord-015306-us58wwmp 1417 2 polymerase polymerase NN cord-015306-us58wwmp 1417 3 chain chain NN cord-015306-us58wwmp 1417 4 reaction reaction NN cord-015306-us58wwmp 1417 5 - - HYPH cord-015306-us58wwmp 1417 6 restriction restriction NN cord-015306-us58wwmp 1417 7 fragment fragment NN cord-015306-us58wwmp 1417 8 length length NN cord-015306-us58wwmp 1417 9 polymorphism polymorphism NN cord-015306-us58wwmp 1417 10 ( ( -LRB- cord-015306-us58wwmp 1417 11 PCR PCR NNP cord-015306-us58wwmp 1417 12 - - HYPH cord-015306-us58wwmp 1417 13 RFLP RFLP NNP cord-015306-us58wwmp 1417 14 ) ) -RRB- cord-015306-us58wwmp 1417 15 method method NN cord-015306-us58wwmp 1417 16 was be VBD cord-015306-us58wwmp 1417 17 utilized utilize VBN cord-015306-us58wwmp 1417 18 to to TO cord-015306-us58wwmp 1417 19 detect detect VB cord-015306-us58wwmp 1417 20 and and CC cord-015306-us58wwmp 1417 21 compare compare VB cord-015306-us58wwmp 1417 22 the the DT cord-015306-us58wwmp 1417 23 genotype genotype NN cord-015306-us58wwmp 1417 24 and and CC cord-015306-us58wwmp 1417 25 allele allele NN cord-015306-us58wwmp 1417 26 frequencies frequency NNS cord-015306-us58wwmp 1417 27 at at IN cord-015306-us58wwmp 1417 28 the the DT cord-015306-us58wwmp 1417 29 TNF TNF NNP cord-015306-us58wwmp 1417 30 - - HYPH cord-015306-us58wwmp 1417 31 α α NNP cord-015306-us58wwmp 1417 32 -308 -308 NN cord-015306-us58wwmp 1417 33 locus locus NN cord-015306-us58wwmp 1417 34 in in IN cord-015306-us58wwmp 1417 35 205 205 CD cord-015306-us58wwmp 1417 36 HSP HSP NNP cord-015306-us58wwmp 1417 37 child child NN cord-015306-us58wwmp 1417 38 patients patient NNS cord-015306-us58wwmp 1417 39 and and CC cord-015306-us58wwmp 1417 40 53 53 CD cord-015306-us58wwmp 1417 41 non non JJ cord-015306-us58wwmp 1417 42 - - JJ cord-015306-us58wwmp 1417 43 HSP hsp JJ cord-015306-us58wwmp 1417 44 child child NN cord-015306-us58wwmp 1417 45 patients patient NNS cord-015306-us58wwmp 1417 46 . . . cord-015306-us58wwmp 1418 1 Furthermore furthermore RB cord-015306-us58wwmp 1418 2 , , , cord-015306-us58wwmp 1418 3 the the DT cord-015306-us58wwmp 1418 4 relationship relationship NN cord-015306-us58wwmp 1418 5 between between IN cord-015306-us58wwmp 1418 6 the the DT cord-015306-us58wwmp 1418 7 genotypic genotypic JJ cord-015306-us58wwmp 1418 8 and and CC cord-015306-us58wwmp 1418 9 allelic allelic JJ cord-015306-us58wwmp 1418 10 frequencies frequency NNS cord-015306-us58wwmp 1418 11 at at IN cord-015306-us58wwmp 1418 12 the the DT cord-015306-us58wwmp 1418 13 TNF TNF NNP cord-015306-us58wwmp 1418 14 - - HYPH cord-015306-us58wwmp 1418 15 α α NNP cord-015306-us58wwmp 1418 16 -308 -308 NN cord-015306-us58wwmp 1418 17 locus locus NN cord-015306-us58wwmp 1418 18 and and CC cord-015306-us58wwmp 1418 19 the the DT cord-015306-us58wwmp 1418 20 susceptibility susceptibility NN cord-015306-us58wwmp 1418 21 to to IN cord-015306-us58wwmp 1418 22 HSP HSP NNP cord-015306-us58wwmp 1418 23 and and CC cord-015306-us58wwmp 1418 24 Henoch Henoch NNP cord-015306-us58wwmp 1418 25 - - HYPH cord-015306-us58wwmp 1418 26 Schonlein Schonlein NNP cord-015306-us58wwmp 1418 27 purpura purpura NN cord-015306-us58wwmp 1418 28 nephritis nephritis NN cord-015306-us58wwmp 1418 29 ( ( -LRB- cord-015306-us58wwmp 1418 30 HSPN HSPN NNP cord-015306-us58wwmp 1418 31 ) ) -RRB- cord-015306-us58wwmp 1418 32 was be VBD cord-015306-us58wwmp 1418 33 analyzed analyze VBN cord-015306-us58wwmp 1418 34 . . . cord-015306-us58wwmp 1419 1 Results result NNS cord-015306-us58wwmp 1419 2 : : : cord-015306-us58wwmp 1419 3 1 1 CD cord-015306-us58wwmp 1419 4 . . . cord-015306-us58wwmp 1420 1 The the DT cord-015306-us58wwmp 1420 2 G g NN cord-015306-us58wwmp 1420 3 / / SYM cord-015306-us58wwmp 1420 4 G g NN cord-015306-us58wwmp 1420 5 , , , cord-015306-us58wwmp 1420 6 G G NNP cord-015306-us58wwmp 1420 7 / / SYM cord-015306-us58wwmp 1420 8 A A NNP cord-015306-us58wwmp 1420 9 , , , cord-015306-us58wwmp 1420 10 and and CC cord-015306-us58wwmp 1420 11 A a DT cord-015306-us58wwmp 1421 1 /A /A NNP cord-015306-us58wwmp 1421 2 genotype genotype NNP cord-015306-us58wwmp 1421 3 frequencies frequency NNS cord-015306-us58wwmp 1421 4 at at IN cord-015306-us58wwmp 1421 5 the the DT cord-015306-us58wwmp 1421 6 TNF TNF NNP cord-015306-us58wwmp 1421 7 - - HYPH cord-015306-us58wwmp 1421 8 α α NNP cord-015306-us58wwmp 1421 9 gene gene NN cord-015306-us58wwmp 1422 1 ( ( -LRB- cord-015306-us58wwmp 1422 2 −308G −308G NNP cord-015306-us58wwmp 1422 3 / / SYM cord-015306-us58wwmp 1422 4 A a NN cord-015306-us58wwmp 1422 5 ) ) -RRB- cord-015306-us58wwmp 1422 6 locus locus NN cord-015306-us58wwmp 1422 7 in in IN cord-015306-us58wwmp 1422 8 the the DT cord-015306-us58wwmp 1422 9 HSP HSP NNP cord-015306-us58wwmp 1422 10 group group NN cord-015306-us58wwmp 1422 11 and and CC cord-015306-us58wwmp 1422 12 the the DT cord-015306-us58wwmp 1422 13 control control NN cord-015306-us58wwmp 1422 14 group group NN cord-015306-us58wwmp 1422 15 were be VBD cord-015306-us58wwmp 1422 16 59.5 59.5 CD cord-015306-us58wwmp 1422 17 % % NN cord-015306-us58wwmp 1422 18 , , , cord-015306-us58wwmp 1422 19 32.2 32.2 CD cord-015306-us58wwmp 1422 20 % % NN cord-015306-us58wwmp 1422 21 , , , cord-015306-us58wwmp 1422 22 and and CC cord-015306-us58wwmp 1422 23 8.3 8.3 CD cord-015306-us58wwmp 1422 24 % % NN cord-015306-us58wwmp 1422 25 and and CC cord-015306-us58wwmp 1422 26 77.4 77.4 CD cord-015306-us58wwmp 1422 27 % % NN cord-015306-us58wwmp 1422 28 , , , cord-015306-us58wwmp 1422 29 20.8 20.8 CD cord-015306-us58wwmp 1422 30 % % NN cord-015306-us58wwmp 1422 31 , , , cord-015306-us58wwmp 1422 32 and and CC cord-015306-us58wwmp 1422 33 1.9 1.9 CD cord-015306-us58wwmp 1422 34 % % NN cord-015306-us58wwmp 1422 35 , , , cord-015306-us58wwmp 1422 36 respectively respectively RB cord-015306-us58wwmp 1422 37 ; ; : cord-015306-us58wwmp 1422 38 among among IN cord-015306-us58wwmp 1422 39 them -PRON- PRP cord-015306-us58wwmp 1422 40 , , , cord-015306-us58wwmp 1422 41 the the DT cord-015306-us58wwmp 1422 42 A A NNP cord-015306-us58wwmp 1422 43 / / SYM cord-015306-us58wwmp 1422 44 A a DT cord-015306-us58wwmp 1422 45 genotype genotype NN cord-015306-us58wwmp 1422 46 frequency frequency NN cord-015306-us58wwmp 1422 47 in in IN cord-015306-us58wwmp 1422 48 the the DT cord-015306-us58wwmp 1422 49 HSP HSP NNP cord-015306-us58wwmp 1422 50 group group NN cord-015306-us58wwmp 1422 51 was be VBD cord-015306-us58wwmp 1422 52 higher high JJR cord-015306-us58wwmp 1422 53 than than IN cord-015306-us58wwmp 1422 54 that that DT cord-015306-us58wwmp 1422 55 in in IN cord-015306-us58wwmp 1422 56 the the DT cord-015306-us58wwmp 1422 57 healthy healthy JJ cord-015306-us58wwmp 1422 58 control control NN cord-015306-us58wwmp 1422 59 group group NN cord-015306-us58wwmp 1422 60 , , , cord-015306-us58wwmp 1422 61 with with IN cord-015306-us58wwmp 1422 62 a a DT cord-015306-us58wwmp 1422 63 statistically statistically RB cord-015306-us58wwmp 1422 64 significant significant JJ cord-015306-us58wwmp 1422 65 difference difference NN cord-015306-us58wwmp 1422 66 ( ( -LRB- cord-015306-us58wwmp 1422 67 x x NN cord-015306-us58wwmp 1422 68 2 2 CD cord-015306-us58wwmp 1422 69 = = SYM cord-015306-us58wwmp 1422 70 6.447 6.447 CD cord-015306-us58wwmp 1422 71 , , , cord-015306-us58wwmp 1422 72 P p NN cord-015306-us58wwmp 1422 73 < < XX cord-015306-us58wwmp 1422 74 0.05 0.05 CD cord-015306-us58wwmp 1422 75 ) ) -RRB- cord-015306-us58wwmp 1422 76 . . . cord-015306-us58wwmp 1423 1 The the DT cord-015306-us58wwmp 1423 2 G g NN cord-015306-us58wwmp 1423 3 and and CC cord-015306-us58wwmp 1423 4 A a DT cord-015306-us58wwmp 1423 5 allele allele NN cord-015306-us58wwmp 1423 6 frequencies frequency NNS cord-015306-us58wwmp 1423 7 in in IN cord-015306-us58wwmp 1423 8 the the DT cord-015306-us58wwmp 1423 9 HSP HSP NNP cord-015306-us58wwmp 1423 10 group group NN cord-015306-us58wwmp 1423 11 and and CC cord-015306-us58wwmp 1423 12 the the DT cord-015306-us58wwmp 1423 13 control control NN cord-015306-us58wwmp 1423 14 group group NN cord-015306-us58wwmp 1423 15 were be VBD cord-015306-us58wwmp 1423 16 75.6 75.6 CD cord-015306-us58wwmp 1423 17 % % NN cord-015306-us58wwmp 1423 18 and and CC cord-015306-us58wwmp 1423 19 24.4 24.4 CD cord-015306-us58wwmp 1423 20 % % NN cord-015306-us58wwmp 1423 21 and and CC cord-015306-us58wwmp 1423 22 87.7 87.7 CD cord-015306-us58wwmp 1423 23 % % NN cord-015306-us58wwmp 1423 24 and and CC cord-015306-us58wwmp 1423 25 12.3 12.3 CD cord-015306-us58wwmp 1423 26 % % NN cord-015306-us58wwmp 1423 27 , , , cord-015306-us58wwmp 1423 28 respectively respectively RB cord-015306-us58wwmp 1423 29 . . . cord-015306-us58wwmp 1424 1 The the DT cord-015306-us58wwmp 1424 2 A a DT cord-015306-us58wwmp 1424 3 allele allele NN cord-015306-us58wwmp 1424 4 frequency frequency NN cord-015306-us58wwmp 1424 5 in in IN cord-015306-us58wwmp 1424 6 the the DT cord-015306-us58wwmp 1424 7 HSP HSP NNP cord-015306-us58wwmp 1424 8 group group NN cord-015306-us58wwmp 1424 9 was be VBD cord-015306-us58wwmp 1424 10 higher high JJR cord-015306-us58wwmp 1424 11 than than IN cord-015306-us58wwmp 1424 12 that that DT cord-015306-us58wwmp 1424 13 in in IN cord-015306-us58wwmp 1424 14 the the DT cord-015306-us58wwmp 1424 15 healthy healthy JJ cord-015306-us58wwmp 1424 16 control control NN cord-015306-us58wwmp 1424 17 group group NN cord-015306-us58wwmp 1424 18 , , , cord-015306-us58wwmp 1424 19 with with IN cord-015306-us58wwmp 1424 20 a a DT cord-015306-us58wwmp 1424 21 statistically statistically RB cord-015306-us58wwmp 1424 22 significant significant JJ cord-015306-us58wwmp 1424 23 difference difference NN cord-015306-us58wwmp 1424 24 ( ( -LRB- cord-015306-us58wwmp 1424 25 x x NN cord-015306-us58wwmp 1424 26 2 2 CD cord-015306-us58wwmp 1424 27 = = SYM cord-015306-us58wwmp 1424 28 7.241 7.241 CD cord-015306-us58wwmp 1424 29 , , , cord-015306-us58wwmp 1424 30 P p NN cord-015306-us58wwmp 1424 31 < < XX cord-015306-us58wwmp 1424 32 0.05 0.05 CD cord-015306-us58wwmp 1424 33 ) ) -RRB- cord-015306-us58wwmp 1424 34 . . . cord-015306-us58wwmp 1425 1 2 2 LS cord-015306-us58wwmp 1425 2 . . . cord-015306-us58wwmp 1426 1 The the DT cord-015306-us58wwmp 1426 2 G g NN cord-015306-us58wwmp 1426 3 / / SYM cord-015306-us58wwmp 1426 4 G g NN cord-015306-us58wwmp 1426 5 , , , cord-015306-us58wwmp 1426 6 G G NNP cord-015306-us58wwmp 1426 7 / / SYM cord-015306-us58wwmp 1426 8 A A NNP cord-015306-us58wwmp 1426 9 , , , cord-015306-us58wwmp 1426 10 and and CC cord-015306-us58wwmp 1426 11 A a DT cord-015306-us58wwmp 1427 1 /A /A NNP cord-015306-us58wwmp 1427 2 genotype genotype NNP cord-015306-us58wwmp 1427 3 frequencies frequency NNS cord-015306-us58wwmp 1427 4 in in IN cord-015306-us58wwmp 1427 5 the the DT cord-015306-us58wwmp 1427 6 HSP HSP NNP cord-015306-us58wwmp 1427 7 non non JJ cord-015306-us58wwmp 1427 8 - - JJ cord-015306-us58wwmp 1427 9 renal renal JJ cord-015306-us58wwmp 1427 10 impairment impairment NN cord-015306-us58wwmp 1427 11 group group NN cord-015306-us58wwmp 1427 12 and and CC cord-015306-us58wwmp 1427 13 the the DT cord-015306-us58wwmp 1427 14 nephritis nephritis NN cord-015306-us58wwmp 1427 15 group group NN cord-015306-us58wwmp 1427 16 were be VBD cord-015306-us58wwmp 1427 17 64.5 64.5 CD cord-015306-us58wwmp 1427 18 % % NN cord-015306-us58wwmp 1427 19 , , , cord-015306-us58wwmp 1427 20 26.4 26.4 CD cord-015306-us58wwmp 1427 21 % % NN cord-015306-us58wwmp 1427 22 , , , cord-015306-us58wwmp 1427 23 and and CC cord-015306-us58wwmp 1427 24 9.1 9.1 CD cord-015306-us58wwmp 1427 25 % % NN cord-015306-us58wwmp 1427 26 and and CC cord-015306-us58wwmp 1427 27 52.4 52.4 CD cord-015306-us58wwmp 1427 28 % % NN cord-015306-us58wwmp 1427 29 , , , cord-015306-us58wwmp 1427 30 40.5 40.5 CD cord-015306-us58wwmp 1427 31 % % NN cord-015306-us58wwmp 1427 32 , , , cord-015306-us58wwmp 1427 33 and and CC cord-015306-us58wwmp 1427 34 7.1 7.1 CD cord-015306-us58wwmp 1427 35 % % NN cord-015306-us58wwmp 1427 36 , , , cord-015306-us58wwmp 1427 37 respectively respectively RB cord-015306-us58wwmp 1427 38 , , , cord-015306-us58wwmp 1427 39 but but CC cord-015306-us58wwmp 1427 40 these these DT cord-015306-us58wwmp 1427 41 differences difference NNS cord-015306-us58wwmp 1427 42 were be VBD cord-015306-us58wwmp 1427 43 not not RB cord-015306-us58wwmp 1427 44 statistically statistically RB cord-015306-us58wwmp 1427 45 significant significant JJ cord-015306-us58wwmp 1428 1 ( ( -LRB- cord-015306-us58wwmp 1428 2 x x SYM cord-015306-us58wwmp 1428 3 2 2 CD cord-015306-us58wwmp 1428 4 = = SYM cord-015306-us58wwmp 1428 5 4.474 4.474 CD cord-015306-us58wwmp 1428 6 , , , cord-015306-us58wwmp 1428 7 P p NN cord-015306-us58wwmp 1428 8 > > XX cord-015306-us58wwmp 1428 9 0.05 0.05 CD cord-015306-us58wwmp 1428 10 ) ) -RRB- cord-015306-us58wwmp 1428 11 . . . cord-015306-us58wwmp 1429 1 The the DT cord-015306-us58wwmp 1429 2 G g NN cord-015306-us58wwmp 1429 3 and and CC cord-015306-us58wwmp 1429 4 A a DT cord-015306-us58wwmp 1429 5 allele allele NN cord-015306-us58wwmp 1429 6 frequencies frequency NNS cord-015306-us58wwmp 1429 7 in in IN cord-015306-us58wwmp 1429 8 the the DT cord-015306-us58wwmp 1429 9 HSP HSP NNP cord-015306-us58wwmp 1429 10 non non JJ cord-015306-us58wwmp 1429 11 - - JJ cord-015306-us58wwmp 1429 12 renal renal JJ cord-015306-us58wwmp 1429 13 impairment impairment NN cord-015306-us58wwmp 1429 14 group group NN cord-015306-us58wwmp 1429 15 and and CC cord-015306-us58wwmp 1429 16 the the DT cord-015306-us58wwmp 1429 17 nephritis nephritis NN cord-015306-us58wwmp 1429 18 group group NN cord-015306-us58wwmp 1429 19 were be VBD cord-015306-us58wwmp 1429 20 77.7 77.7 CD cord-015306-us58wwmp 1429 21 % % NN cord-015306-us58wwmp 1429 22 and and CC cord-015306-us58wwmp 1429 23 22.3 22.3 CD cord-015306-us58wwmp 1429 24 % % NN cord-015306-us58wwmp 1429 25 and and CC cord-015306-us58wwmp 1429 26 72.6 72.6 CD cord-015306-us58wwmp 1429 27 % % NN cord-015306-us58wwmp 1429 28 and and CC cord-015306-us58wwmp 1429 29 27.4 27.4 CD cord-015306-us58wwmp 1429 30 % % NN cord-015306-us58wwmp 1429 31 , , , cord-015306-us58wwmp 1429 32 respectively respectively RB cord-015306-us58wwmp 1429 33 ; ; : cord-015306-us58wwmp 1429 34 the the DT cord-015306-us58wwmp 1429 35 difference difference NN cord-015306-us58wwmp 1429 36 in in IN cord-015306-us58wwmp 1429 37 the the DT cord-015306-us58wwmp 1429 38 frequency frequency NN cord-015306-us58wwmp 1429 39 of of IN cord-015306-us58wwmp 1429 40 the the DT cord-015306-us58wwmp 1429 41 A a DT cord-015306-us58wwmp 1429 42 allele allele NN cord-015306-us58wwmp 1429 43 in in IN cord-015306-us58wwmp 1429 44 the the DT cord-015306-us58wwmp 1429 45 HSP HSP NNP cord-015306-us58wwmp 1429 46 non non JJ cord-015306-us58wwmp 1429 47 - - JJ cord-015306-us58wwmp 1429 48 renal renal JJ cord-015306-us58wwmp 1429 49 - - HYPH cord-015306-us58wwmp 1429 50 damage damage NN cord-015306-us58wwmp 1429 51 group group NN cord-015306-us58wwmp 1429 52 and and CC cord-015306-us58wwmp 1429 53 the the DT cord-015306-us58wwmp 1429 54 nephritis nephritis NN cord-015306-us58wwmp 1429 55 group group NN cord-015306-us58wwmp 1429 56 was be VBD cord-015306-us58wwmp 1429 57 not not RB cord-015306-us58wwmp 1429 58 statistically statistically RB cord-015306-us58wwmp 1429 59 significant significant JJ cord-015306-us58wwmp 1430 1 ( ( -LRB- cord-015306-us58wwmp 1430 2 x x SYM cord-015306-us58wwmp 1430 3 2 2 CD cord-015306-us58wwmp 1430 4 = = SYM cord-015306-us58wwmp 1430 5 0.240 0.240 CD cord-015306-us58wwmp 1430 6 , , , cord-015306-us58wwmp 1431 1 P p NN cord-015306-us58wwmp 1431 2 > > XX cord-015306-us58wwmp 1431 3 0.05 0.05 CD cord-015306-us58wwmp 1431 4 ) ) -RRB- cord-015306-us58wwmp 1431 5 . . . cord-015306-us58wwmp 1432 1 Conclusion conclusion NN cord-015306-us58wwmp 1432 2 : : : cord-015306-us58wwmp 1433 1 The the DT cord-015306-us58wwmp 1433 2 TNF TNF NNP cord-015306-us58wwmp 1433 3 - - HYPH cord-015306-us58wwmp 1433 4 α α NNP cord-015306-us58wwmp 1433 5 ( ( -LRB- cord-015306-us58wwmp 1433 6 −308G −308G NNP cord-015306-us58wwmp 1433 7 / / SYM cord-015306-us58wwmp 1433 8 A a NN cord-015306-us58wwmp 1433 9 ) ) -RRB- cord-015306-us58wwmp 1433 10 gene gene NN cord-015306-us58wwmp 1433 11 polymorphism polymorphism NN cord-015306-us58wwmp 1433 12 was be VBD cord-015306-us58wwmp 1433 13 associated associate VBN cord-015306-us58wwmp 1433 14 with with IN cord-015306-us58wwmp 1433 15 HSP HSP NNP cord-015306-us58wwmp 1433 16 in in IN cord-015306-us58wwmp 1433 17 children child NNS cord-015306-us58wwmp 1433 18 . . . cord-015306-us58wwmp 1434 1 A/ A/ NNP cord-015306-us58wwmp 1435 1 A a DT cord-015306-us58wwmp 1435 2 homozygosity homozygosity NN cord-015306-us58wwmp 1435 3 may may MD cord-015306-us58wwmp 1435 4 be be VB cord-015306-us58wwmp 1435 5 a a DT cord-015306-us58wwmp 1435 6 genetic genetic JJ cord-015306-us58wwmp 1435 7 predisposing predisposing NN cord-015306-us58wwmp 1435 8 factor factor NN cord-015306-us58wwmp 1435 9 for for IN cord-015306-us58wwmp 1435 10 HSP HSP NNP cord-015306-us58wwmp 1435 11 ; ; : cord-015306-us58wwmp 1435 12 however however RB cord-015306-us58wwmp 1435 13 , , , cord-015306-us58wwmp 1435 14 this this DT cord-015306-us58wwmp 1435 15 factor factor NN cord-015306-us58wwmp 1435 16 was be VBD cord-015306-us58wwmp 1435 17 not not RB cord-015306-us58wwmp 1435 18 significantly significantly RB cord-015306-us58wwmp 1435 19 correlated correlate VBN cord-015306-us58wwmp 1435 20 with with IN cord-015306-us58wwmp 1435 21 the the DT cord-015306-us58wwmp 1435 22 development development NN cord-015306-us58wwmp 1435 23 of of IN cord-015306-us58wwmp 1435 24 kidney kidney NN cord-015306-us58wwmp 1435 25 damage damage NN cord-015306-us58wwmp 1435 26 . . . cord-015306-us58wwmp 1436 1 Abstract abstract JJ cord-015306-us58wwmp 1436 2 # # NN cord-015306-us58wwmp 1436 3 P p NN cord-015306-us58wwmp 1436 4 - - , cord-015306-us58wwmp 1436 5 SAT175 sat175 JJ cord-015306-us58wwmp 1436 6 Objective objective NN cord-015306-us58wwmp 1436 7 : : : cord-015306-us58wwmp 1437 1 The the DT cord-015306-us58wwmp 1437 2 nephrotic nephrotic JJ cord-015306-us58wwmp 1437 3 syndrome syndrome NN cord-015306-us58wwmp 1437 4 ( ( -LRB- cord-015306-us58wwmp 1437 5 NS NS NNP cord-015306-us58wwmp 1437 6 ) ) -RRB- cord-015306-us58wwmp 1437 7 is be VBZ cord-015306-us58wwmp 1437 8 characterized characterize VBN cord-015306-us58wwmp 1437 9 by by IN cord-015306-us58wwmp 1437 10 proteinuria proteinuria NN cord-015306-us58wwmp 1437 11 , , , cord-015306-us58wwmp 1437 12 hypoalbuminemia hypoalbuminemia NN cord-015306-us58wwmp 1437 13 and and CC cord-015306-us58wwmp 1437 14 generalized generalized JJ cord-015306-us58wwmp 1437 15 edema edema NN cord-015306-us58wwmp 1437 16 . . . cord-015306-us58wwmp 1438 1 Although although IN cord-015306-us58wwmp 1438 2 the the DT cord-015306-us58wwmp 1438 3 pathophysiological pathophysiological JJ cord-015306-us58wwmp 1438 4 mechanisms mechanism NNS cord-015306-us58wwmp 1438 5 of of IN cord-015306-us58wwmp 1438 6 NS NS NNP cord-015306-us58wwmp 1438 7 remain remain VBP cord-015306-us58wwmp 1438 8 unknown unknown JJ cord-015306-us58wwmp 1438 9 , , , cord-015306-us58wwmp 1438 10 studies study NNS cord-015306-us58wwmp 1438 11 with with IN cord-015306-us58wwmp 1438 12 animal animal NN cord-015306-us58wwmp 1438 13 models model NNS cord-015306-us58wwmp 1438 14 and and CC cord-015306-us58wwmp 1438 15 patients patient NNS cord-015306-us58wwmp 1438 16 have have VBP cord-015306-us58wwmp 1438 17 associated associate VBN cord-015306-us58wwmp 1438 18 the the DT cord-015306-us58wwmp 1438 19 NS NS NNP cord-015306-us58wwmp 1438 20 with with IN cord-015306-us58wwmp 1438 21 changes change NNS cord-015306-us58wwmp 1438 22 in in IN cord-015306-us58wwmp 1438 23 immune immune JJ cord-015306-us58wwmp 1438 24 response response NN cord-015306-us58wwmp 1438 25 . . . cord-015306-us58wwmp 1439 1 The the DT cord-015306-us58wwmp 1439 2 present present JJ cord-015306-us58wwmp 1439 3 study study NN cord-015306-us58wwmp 1439 4 investigated investigate VBD cord-015306-us58wwmp 1439 5 the the DT cord-015306-us58wwmp 1439 6 expression expression NN cord-015306-us58wwmp 1439 7 of of IN cord-015306-us58wwmp 1439 8 molecules molecule NNS cord-015306-us58wwmp 1439 9 related relate VBN cord-015306-us58wwmp 1439 10 to to IN cord-015306-us58wwmp 1439 11 cell cell NN cord-015306-us58wwmp 1439 12 activation activation NN cord-015306-us58wwmp 1439 13 , , , cord-015306-us58wwmp 1439 14 such such JJ cord-015306-us58wwmp 1439 15 as as IN cord-015306-us58wwmp 1439 16 the the DT cord-015306-us58wwmp 1439 17 beta-2 beta-2 NN cord-015306-us58wwmp 1439 18 integrin integrin NN cord-015306-us58wwmp 1439 19 ( ( -LRB- cord-015306-us58wwmp 1439 20 CD18 CD18 NNP cord-015306-us58wwmp 1439 21 ) ) -RRB- cord-015306-us58wwmp 1439 22 and and CC cord-015306-us58wwmp 1439 23 CD80 CD80 NNP cord-015306-us58wwmp 1439 24 on on IN cord-015306-us58wwmp 1439 25 peripheral peripheral JJ cord-015306-us58wwmp 1439 26 blood blood NN cord-015306-us58wwmp 1439 27 leukocytes leukocyte NNS cord-015306-us58wwmp 1439 28 and and CC cord-015306-us58wwmp 1439 29 renal renal JJ cord-015306-us58wwmp 1439 30 production production NN cord-015306-us58wwmp 1439 31 of of IN cord-015306-us58wwmp 1439 32 reactive reactive JJ cord-015306-us58wwmp 1439 33 oxygen oxygen NN cord-015306-us58wwmp 1439 34 species specie NNS cord-015306-us58wwmp 1439 35 in in IN cord-015306-us58wwmp 1439 36 rats rat NNS cord-015306-us58wwmp 1439 37 with with IN cord-015306-us58wwmp 1439 38 NS NS NNP cord-015306-us58wwmp 1439 39 induced induce VBN cord-015306-us58wwmp 1439 40 by by IN cord-015306-us58wwmp 1439 41 Doxorubicin Doxorubicin NNP cord-015306-us58wwmp 1439 42 . . . cord-015306-us58wwmp 1440 1 Meathods Meathods NNP cord-015306-us58wwmp 1440 2 : : : cord-015306-us58wwmp 1441 1 Male male JJ cord-015306-us58wwmp 1441 2 Wistar Wistar NNP cord-015306-us58wwmp 1441 3 rats rat NNS cord-015306-us58wwmp 1441 4 , , , cord-015306-us58wwmp 1441 5 250 250 CD cord-015306-us58wwmp 1441 6 - - SYM cord-015306-us58wwmp 1441 7 300 300 CD cord-015306-us58wwmp 1441 8 g g NN cord-015306-us58wwmp 1441 9 , , , cord-015306-us58wwmp 1441 10 were be VBD cord-015306-us58wwmp 1441 11 divided divide VBN cord-015306-us58wwmp 1441 12 into into IN cord-015306-us58wwmp 1441 13 two two CD cord-015306-us58wwmp 1441 14 groups group NNS cord-015306-us58wwmp 1441 15 : : : cord-015306-us58wwmp 1441 16 animals animal NNS cord-015306-us58wwmp 1441 17 receiving receive VBG cord-015306-us58wwmp 1441 18 intravenous intravenous JJ cord-015306-us58wwmp 1441 19 injection injection NN cord-015306-us58wwmp 1441 20 of of IN cord-015306-us58wwmp 1441 21 doxorubicin doxorubicin NN cord-015306-us58wwmp 1441 22 ( ( -LRB- cord-015306-us58wwmp 1441 23 7.5 7.5 CD cord-015306-us58wwmp 1441 24 mg mg NN cord-015306-us58wwmp 1441 25 / / SYM cord-015306-us58wwmp 1441 26 kg kg NNP cord-015306-us58wwmp 1441 27 ) ) -RRB- cord-015306-us58wwmp 1441 28 ( ( -LRB- cord-015306-us58wwmp 1441 29 DOX DOX NNP cord-015306-us58wwmp 1441 30 , , , cord-015306-us58wwmp 1441 31 n=32 n=32 NNP cord-015306-us58wwmp 1441 32 ) ) -RRB- cord-015306-us58wwmp 1441 33 and and CC cord-015306-us58wwmp 1441 34 control control NN cord-015306-us58wwmp 1441 35 animals animal NNS cord-015306-us58wwmp 1441 36 that that WDT cord-015306-us58wwmp 1441 37 received receive VBD cord-015306-us58wwmp 1441 38 saline saline NN cord-015306-us58wwmp 1441 39 ( ( -LRB- cord-015306-us58wwmp 1441 40 CON con NN cord-015306-us58wwmp 1441 41 , , , cord-015306-us58wwmp 1441 42 n=32 n=32 NNP cord-015306-us58wwmp 1441 43 ) ) -RRB- cord-015306-us58wwmp 1441 44 . . . cord-015306-us58wwmp 1442 1 The the DT cord-015306-us58wwmp 1442 2 animals animal NNS cord-015306-us58wwmp 1442 3 were be VBD cord-015306-us58wwmp 1442 4 sacrificed sacrifice VBN cord-015306-us58wwmp 1442 5 at at IN cord-015306-us58wwmp 1442 6 days day NNS cord-015306-us58wwmp 1442 7 7 7 CD cord-015306-us58wwmp 1442 8 , , , cord-015306-us58wwmp 1442 9 14 14 CD cord-015306-us58wwmp 1442 10 , , , cord-015306-us58wwmp 1442 11 21 21 CD cord-015306-us58wwmp 1442 12 and and CC cord-015306-us58wwmp 1442 13 28 28 CD cord-015306-us58wwmp 1442 14 after after IN cord-015306-us58wwmp 1442 15 injection injection NN cord-015306-us58wwmp 1442 16 , , , cord-015306-us58wwmp 1442 17 and and CC cord-015306-us58wwmp 1442 18 24 24 CD cord-015306-us58wwmp 1442 19 hour hour NN cord-015306-us58wwmp 1442 20 urine urine NN cord-015306-us58wwmp 1442 21 and and CC cord-015306-us58wwmp 1442 22 blood blood NN cord-015306-us58wwmp 1442 23 samples sample NNS cord-015306-us58wwmp 1442 24 were be VBD cord-015306-us58wwmp 1442 25 collected collect VBN cord-015306-us58wwmp 1442 26 for for IN cord-015306-us58wwmp 1442 27 biochemical biochemical JJ cord-015306-us58wwmp 1442 28 and and CC cord-015306-us58wwmp 1442 29 immunological immunological JJ cord-015306-us58wwmp 1442 30 analyzes analyze NNS cord-015306-us58wwmp 1442 31 . . . cord-015306-us58wwmp 1443 1 The the DT cord-015306-us58wwmp 1443 2 phenotypic phenotypic JJ cord-015306-us58wwmp 1443 3 analysis analysis NN cord-015306-us58wwmp 1443 4 of of IN cord-015306-us58wwmp 1443 5 leukocytes leukocyte NNS cord-015306-us58wwmp 1443 6 was be VBD cord-015306-us58wwmp 1443 7 performed perform VBN cord-015306-us58wwmp 1443 8 by by IN cord-015306-us58wwmp 1443 9 flow flow NN cord-015306-us58wwmp 1443 10 cytometry cytometry NN cord-015306-us58wwmp 1443 11 . . . cord-015306-us58wwmp 1444 1 The the DT cord-015306-us58wwmp 1444 2 expression expression NN cord-015306-us58wwmp 1444 3 of of IN cord-015306-us58wwmp 1444 4 CD18 CD18 NNP cord-015306-us58wwmp 1444 5 in in IN cord-015306-us58wwmp 1444 6 monocytes monocyte NNS cord-015306-us58wwmp 1444 7 , , , cord-015306-us58wwmp 1444 8 CD4 CD4 NNP cord-015306-us58wwmp 1444 9 + + CC cord-015306-us58wwmp 1444 10 , , , cord-015306-us58wwmp 1444 11 CD8 CD8 NNP cord-015306-us58wwmp 1444 12 + + CC cord-015306-us58wwmp 1444 13 and and CC cord-015306-us58wwmp 1444 14 NK NK NNP cord-015306-us58wwmp 1444 15 cells cell NNS cord-015306-us58wwmp 1444 16 and and CC cord-015306-us58wwmp 1444 17 the the DT cord-015306-us58wwmp 1444 18 expression expression NN cord-015306-us58wwmp 1444 19 of of IN cord-015306-us58wwmp 1444 20 CD80 CD80 NNP cord-015306-us58wwmp 1444 21 in in IN cord-015306-us58wwmp 1444 22 monocytes monocyte NNS cord-015306-us58wwmp 1444 23 were be VBD cord-015306-us58wwmp 1444 24 measured measure VBN cord-015306-us58wwmp 1444 25 . . . cord-015306-us58wwmp 1445 1 In in IN cord-015306-us58wwmp 1445 2 renal renal JJ cord-015306-us58wwmp 1445 3 tissue tissue NN cord-015306-us58wwmp 1445 4 samples sample NNS cord-015306-us58wwmp 1445 5 , , , cord-015306-us58wwmp 1445 6 the the DT cord-015306-us58wwmp 1445 7 oxidative oxidative JJ cord-015306-us58wwmp 1445 8 activity activity NN cord-015306-us58wwmp 1445 9 was be VBD cord-015306-us58wwmp 1445 10 evaluated evaluate VBN cord-015306-us58wwmp 1445 11 by by IN cord-015306-us58wwmp 1445 12 TBARS TBARS NNP cord-015306-us58wwmp 1445 13 production production NN cord-015306-us58wwmp 1445 14 and and CC cord-015306-us58wwmp 1445 15 antioxidant antioxidant JJ cord-015306-us58wwmp 1445 16 activity activity NN cord-015306-us58wwmp 1445 17 of of IN cord-015306-us58wwmp 1445 18 SOD sod NN cord-015306-us58wwmp 1445 19 and and CC cord-015306-us58wwmp 1445 20 catalase catalase NN cord-015306-us58wwmp 1445 21 . . . cord-015306-us58wwmp 1446 1 Results result NNS cord-015306-us58wwmp 1446 2 : : : cord-015306-us58wwmp 1447 1 The the DT cord-015306-us58wwmp 1447 2 DOX DOX NNP cord-015306-us58wwmp 1447 3 group group NN cord-015306-us58wwmp 1447 4 animals animal NNS cord-015306-us58wwmp 1447 5 showed show VBD cord-015306-us58wwmp 1447 6 significant significant JJ cord-015306-us58wwmp 1447 7 increase increase NN cord-015306-us58wwmp 1447 8 in in IN cord-015306-us58wwmp 1447 9 cellular cellular JJ cord-015306-us58wwmp 1447 10 CD18 CD18 NNP cord-015306-us58wwmp 1447 11 expression expression NN cord-015306-us58wwmp 1447 12 and and CC cord-015306-us58wwmp 1447 13 in in IN cord-015306-us58wwmp 1447 14 the the DT cord-015306-us58wwmp 1447 15 percentage percentage NN cord-015306-us58wwmp 1447 16 of of IN cord-015306-us58wwmp 1447 17 cytotoxic cytotoxic JJ cord-015306-us58wwmp 1447 18 T t NN cord-015306-us58wwmp 1447 19 lymphocytes lymphocyte NNS cord-015306-us58wwmp 1447 20 , , , cord-015306-us58wwmp 1447 21 NK NK NNP cord-015306-us58wwmp 1447 22 cells cell NNS cord-015306-us58wwmp 1447 23 and and CC cord-015306-us58wwmp 1447 24 monocytes monocyte NNS cord-015306-us58wwmp 1447 25 that that WDT cord-015306-us58wwmp 1447 26 expressed express VBD cord-015306-us58wwmp 1447 27 CD18 CD18 NNP cord-015306-us58wwmp 1447 28 as as RB cord-015306-us58wwmp 1447 29 well well RB cord-015306-us58wwmp 1447 30 as as IN cord-015306-us58wwmp 1447 31 raised raise VBN cord-015306-us58wwmp 1447 32 CD80 CD80 NNP cord-015306-us58wwmp 1447 33 expression expression NN cord-015306-us58wwmp 1447 34 on on IN cord-015306-us58wwmp 1447 35 peripheral peripheral JJ cord-015306-us58wwmp 1447 36 blood blood NN cord-015306-us58wwmp 1447 37 monocytes monocyte NNS cord-015306-us58wwmp 1447 38 when when WRB cord-015306-us58wwmp 1447 39 compared compare VBN cord-015306-us58wwmp 1447 40 to to IN cord-015306-us58wwmp 1447 41 the the DT cord-015306-us58wwmp 1447 42 CON con NN cord-015306-us58wwmp 1447 43 group group NN cord-015306-us58wwmp 1447 44 . . . cord-015306-us58wwmp 1448 1 The the DT cord-015306-us58wwmp 1448 2 increased increased JJ cord-015306-us58wwmp 1448 3 production production NN cord-015306-us58wwmp 1448 4 of of IN cord-015306-us58wwmp 1448 5 reactive reactive JJ cord-015306-us58wwmp 1448 6 oxygen oxygen NN cord-015306-us58wwmp 1448 7 species specie NNS cord-015306-us58wwmp 1448 8 in in IN cord-015306-us58wwmp 1448 9 renal renal JJ cord-015306-us58wwmp 1448 10 tissue tissue NN cord-015306-us58wwmp 1448 11 of of IN cord-015306-us58wwmp 1448 12 DOX DOX NNP cord-015306-us58wwmp 1448 13 group group NN cord-015306-us58wwmp 1448 14 animals animal NNS cord-015306-us58wwmp 1448 15 was be VBD cord-015306-us58wwmp 1448 16 positively positively RB cord-015306-us58wwmp 1448 17 correlated correlate VBN cord-015306-us58wwmp 1448 18 with with IN cord-015306-us58wwmp 1448 19 the the DT cord-015306-us58wwmp 1448 20 CD80 CD80 NNP cord-015306-us58wwmp 1448 21 expression expression NN cord-015306-us58wwmp 1448 22 on on IN cord-015306-us58wwmp 1448 23 monocytes monocyte NNS cord-015306-us58wwmp 1448 24 and and CC cord-015306-us58wwmp 1448 25 serum serum NN cord-015306-us58wwmp 1448 26 levels level NNS cord-015306-us58wwmp 1448 27 of of IN cord-015306-us58wwmp 1448 28 creatinine creatinine NN cord-015306-us58wwmp 1448 29 . . . cord-015306-us58wwmp 1449 1 Conclusion conclusion NN cord-015306-us58wwmp 1449 2 : : : cord-015306-us58wwmp 1450 1 These these DT cord-015306-us58wwmp 1450 2 findings finding NNS cord-015306-us58wwmp 1450 3 indicate indicate VBP cord-015306-us58wwmp 1450 4 a a DT cord-015306-us58wwmp 1450 5 potential potential JJ cord-015306-us58wwmp 1450 6 link link NN cord-015306-us58wwmp 1450 7 between between IN cord-015306-us58wwmp 1450 8 increased increase VBN cord-015306-us58wwmp 1450 9 activation activation NN cord-015306-us58wwmp 1450 10 of of IN cord-015306-us58wwmp 1450 11 peripheral peripheral JJ cord-015306-us58wwmp 1450 12 monocytes monocyte NNS cord-015306-us58wwmp 1450 13 and and CC cord-015306-us58wwmp 1450 14 kidney kidney NN cord-015306-us58wwmp 1450 15 damage damage NN cord-015306-us58wwmp 1450 16 in in IN cord-015306-us58wwmp 1450 17 animals animal NNS cord-015306-us58wwmp 1450 18 with with IN cord-015306-us58wwmp 1450 19 NS NS NNP cord-015306-us58wwmp 1450 20 . . . cord-015306-us58wwmp 1451 1 Additional additional JJ cord-015306-us58wwmp 1451 2 studies study NNS cord-015306-us58wwmp 1451 3 analyzing analyze VBG cord-015306-us58wwmp 1451 4 the the DT cord-015306-us58wwmp 1451 5 effects effect NNS cord-015306-us58wwmp 1451 6 of of IN cord-015306-us58wwmp 1451 7 the the DT cord-015306-us58wwmp 1451 8 blockade blockade NN cord-015306-us58wwmp 1451 9 of of IN cord-015306-us58wwmp 1451 10 integrins integrin NNS cord-015306-us58wwmp 1451 11 and and CC cord-015306-us58wwmp 1451 12 co co JJ cord-015306-us58wwmp 1451 13 - - JJ cord-015306-us58wwmp 1451 14 stimulatory stimulatory JJ cord-015306-us58wwmp 1451 15 molecules molecule NNS cord-015306-us58wwmp 1451 16 may may MD cord-015306-us58wwmp 1451 17 offer offer VB cord-015306-us58wwmp 1451 18 new new JJ cord-015306-us58wwmp 1451 19 therapeutic therapeutic JJ cord-015306-us58wwmp 1451 20 opportunities opportunity NNS cord-015306-us58wwmp 1451 21 to to TO cord-015306-us58wwmp 1451 22 treat treat VB cord-015306-us58wwmp 1451 23 human human JJ cord-015306-us58wwmp 1451 24 NS NS NNP cord-015306-us58wwmp 1451 25 . . . cord-015306-us58wwmp 1452 1 Abstract abstract JJ cord-015306-us58wwmp 1452 2 # # NN cord-015306-us58wwmp 1453 1 P p NN cord-015306-us58wwmp 1453 2 - - HYPH cord-015306-us58wwmp 1453 3 SAT182 SAT182 NNP cord-015306-us58wwmp 1453 4 Cyclosporine Cyclosporine NNP cord-015306-us58wwmp 1453 5 A A NNP cord-015306-us58wwmp 1453 6 protects protect VBZ cord-015306-us58wwmp 1453 7 podocyte podocyte NN cord-015306-us58wwmp 1453 8 via via IN cord-015306-us58wwmp 1453 9 upregulating upregulate VBG cord-015306-us58wwmp 1453 10 the the DT cord-015306-us58wwmp 1453 11 expression expression NN cord-015306-us58wwmp 1453 12 of of IN cord-015306-us58wwmp 1453 13 cofilin-1 cofilin-1 NNP cord-015306-us58wwmp 1454 1 Li Li NNP cord-015306-us58wwmp 1454 2 xiaoyan xiaoyan NNP cord-015306-us58wwmp 1454 3 , , , cord-015306-us58wwmp 1454 4 Zhang Zhang NNP cord-015306-us58wwmp 1454 5 xiaoyan xiaoyan NNP cord-015306-us58wwmp 1454 6 , , , cord-015306-us58wwmp 1454 7 Li Li NNP cord-015306-us58wwmp 1454 8 xuejuan xuejuan NNP cord-015306-us58wwmp 1454 9 , , , cord-015306-us58wwmp 1454 10 Wang Wang NNP cord-015306-us58wwmp 1454 11 xuejing xuejing NN cord-015306-us58wwmp 1454 12 , , , cord-015306-us58wwmp 1454 13 Wang Wang NNP cord-015306-us58wwmp 1454 14 suxia suxia NNP cord-015306-us58wwmp 1454 15 , , , cord-015306-us58wwmp 1454 16 Ding Ding NNP cord-015306-us58wwmp 1454 17 jie jie NNP cord-015306-us58wwmp 1454 18 Pediatric Pediatric NNP cord-015306-us58wwmp 1454 19 , , , cord-015306-us58wwmp 1454 20 Peking Peking NNP cord-015306-us58wwmp 1454 21 University University NNP cord-015306-us58wwmp 1454 22 First First NNP cord-015306-us58wwmp 1454 23 Hospital Hospital NNP cord-015306-us58wwmp 1454 24 , , , cord-015306-us58wwmp 1454 25 Beijing Beijing NNP cord-015306-us58wwmp 1454 26 , , , cord-015306-us58wwmp 1455 1 China China NNP cord-015306-us58wwmp 1455 2 Objective Objective NNP cord-015306-us58wwmp 1455 3 : : : cord-015306-us58wwmp 1456 1 Podocyte Podocyte NNP cord-015306-us58wwmp 1456 2 foot foot NN cord-015306-us58wwmp 1456 3 process process NN cord-015306-us58wwmp 1456 4 is be VBZ cord-015306-us58wwmp 1456 5 dysregulated dysregulate VBN cord-015306-us58wwmp 1456 6 in in IN cord-015306-us58wwmp 1456 7 nephrotic nephrotic JJ cord-015306-us58wwmp 1456 8 syndrome syndrome NN cord-015306-us58wwmp 1456 9 . . . cord-015306-us58wwmp 1457 1 The the DT cord-015306-us58wwmp 1457 2 effacement effacement NN cord-015306-us58wwmp 1457 3 of of IN cord-015306-us58wwmp 1457 4 podocyte podocyte NNP cord-015306-us58wwmp 1457 5 foot foot NN cord-015306-us58wwmp 1457 6 processes process NNS cord-015306-us58wwmp 1457 7 typically typically RB cord-015306-us58wwmp 1457 8 arises arise VBZ cord-015306-us58wwmp 1457 9 owing owe VBG cord-015306-us58wwmp 1457 10 to to IN cord-015306-us58wwmp 1457 11 perturbations perturbation NNS cord-015306-us58wwmp 1457 12 in in IN cord-015306-us58wwmp 1457 13 the the DT cord-015306-us58wwmp 1457 14 actin actin NN cord-015306-us58wwmp 1457 15 cytoskeleton cytoskeleton NN cord-015306-us58wwmp 1457 16 . . . cord-015306-us58wwmp 1458 1 Calcineurin Calcineurin NNP cord-015306-us58wwmp 1458 2 inhibitor inhibitor NN cord-015306-us58wwmp 1458 3 Cyclosporien Cyclosporien NNP cord-015306-us58wwmp 1458 4 A A NNP cord-015306-us58wwmp 1458 5 ( ( -LRB- cord-015306-us58wwmp 1458 6 CsA CsA NNP cord-015306-us58wwmp 1458 7 ) ) -RRB- cord-015306-us58wwmp 1458 8 is be VBZ cord-015306-us58wwmp 1458 9 currently currently RB cord-015306-us58wwmp 1458 10 used use VBN cord-015306-us58wwmp 1458 11 in in IN cord-015306-us58wwmp 1458 12 the the DT cord-015306-us58wwmp 1458 13 treatment treatment NN cord-015306-us58wwmp 1458 14 of of IN cord-015306-us58wwmp 1458 15 nephrotic nephrotic JJ cord-015306-us58wwmp 1458 16 syndrome syndrome NN cord-015306-us58wwmp 1458 17 . . . cord-015306-us58wwmp 1459 1 Recent recent JJ cord-015306-us58wwmp 1459 2 data datum NNS cord-015306-us58wwmp 1459 3 suggest suggest VBP cord-015306-us58wwmp 1459 4 that that IN cord-015306-us58wwmp 1459 5 the the DT cord-015306-us58wwmp 1459 6 effects effect NNS cord-015306-us58wwmp 1459 7 of of IN cord-015306-us58wwmp 1459 8 CsA csa NN cord-015306-us58wwmp 1459 9 on on IN cord-015306-us58wwmp 1459 10 nephrotic nephrotic JJ cord-015306-us58wwmp 1459 11 syndrome syndrome NN cord-015306-us58wwmp 1459 12 are be VBP cord-015306-us58wwmp 1459 13 independent independent JJ cord-015306-us58wwmp 1459 14 of of IN cord-015306-us58wwmp 1459 15 its -PRON- PRP$ cord-015306-us58wwmp 1459 16 effects effect NNS cord-015306-us58wwmp 1459 17 on on IN cord-015306-us58wwmp 1459 18 the the DT cord-015306-us58wwmp 1459 19 immune immune JJ cord-015306-us58wwmp 1459 20 system system NN cord-015306-us58wwmp 1459 21 . . . cord-015306-us58wwmp 1460 1 They -PRON- PRP cord-015306-us58wwmp 1460 2 identified identify VBD cord-015306-us58wwmp 1460 3 that that IN cord-015306-us58wwmp 1460 4 CsA csa NN cord-015306-us58wwmp 1460 5 can can MD cord-015306-us58wwmp 1460 6 stabilize stabilize VB cord-015306-us58wwmp 1460 7 the the DT cord-015306-us58wwmp 1460 8 actin actin NN cord-015306-us58wwmp 1460 9 cytoskeleton cytoskeleton NN cord-015306-us58wwmp 1460 10 through through IN cord-015306-us58wwmp 1460 11 stabilizing stabilize VBG cord-015306-us58wwmp 1460 12 synaptopodin synaptopodin NNS cord-015306-us58wwmp 1460 13 in in IN cord-015306-us58wwmp 1460 14 podocytes podocyte NNS cord-015306-us58wwmp 1460 15 and and CC cord-015306-us58wwmp 1460 16 thereby thereby RB cord-015306-us58wwmp 1460 17 reduce reduce VB cord-015306-us58wwmp 1460 18 proteinuria proteinuria NN cord-015306-us58wwmp 1460 19 directly directly RB cord-015306-us58wwmp 1460 20 . . . cord-015306-us58wwmp 1461 1 Other other JJ cord-015306-us58wwmp 1461 2 studies study NNS cord-015306-us58wwmp 1461 3 also also RB cord-015306-us58wwmp 1461 4 showed show VBD cord-015306-us58wwmp 1461 5 that that IN cord-015306-us58wwmp 1461 6 CsA csa NN cord-015306-us58wwmp 1461 7 induced induce VBN cord-015306-us58wwmp 1461 8 cofilin cofilin NNP cord-015306-us58wwmp 1461 9 phosphorylation phosphorylation NN cord-015306-us58wwmp 1461 10 and and CC cord-015306-us58wwmp 1461 11 promoted promote VBN cord-015306-us58wwmp 1461 12 stress stress NN cord-015306-us58wwmp 1461 13 fiber fiber NN cord-015306-us58wwmp 1461 14 generation generation NN cord-015306-us58wwmp 1461 15 in in IN cord-015306-us58wwmp 1461 16 proximal proximal JJ cord-015306-us58wwmp 1461 17 tubular tubular JJ cord-015306-us58wwmp 1461 18 cells cell NNS cord-015306-us58wwmp 1461 19 . . . cord-015306-us58wwmp 1462 1 However however RB cord-015306-us58wwmp 1462 2 , , , cord-015306-us58wwmp 1462 3 whether whether IN cord-015306-us58wwmp 1462 4 the the DT cord-015306-us58wwmp 1462 5 antiproteinuric antiproteinuric JJ cord-015306-us58wwmp 1462 6 role role NN cord-015306-us58wwmp 1462 7 of of IN cord-015306-us58wwmp 1462 8 CsA CsA NNP cord-015306-us58wwmp 1462 9 is be VBZ cord-015306-us58wwmp 1462 10 played play VBN cord-015306-us58wwmp 1462 11 by by IN cord-015306-us58wwmp 1462 12 regulating regulate VBG cord-015306-us58wwmp 1462 13 cofilin-1 cofilin-1 NNP cord-015306-us58wwmp 1462 14 in in IN cord-015306-us58wwmp 1462 15 podocyte podocyte NNP cord-015306-us58wwmp 1462 16 has have VBZ cord-015306-us58wwmp 1462 17 not not RB cord-015306-us58wwmp 1462 18 been be VBN cord-015306-us58wwmp 1462 19 studied study VBN cord-015306-us58wwmp 1462 20 . . . cord-015306-us58wwmp 1463 1 Methods method NNS cord-015306-us58wwmp 1463 2 : : : cord-015306-us58wwmp 1464 1 Acute acute JJ cord-015306-us58wwmp 1464 2 podocyte podocyte NNP cord-015306-us58wwmp 1464 3 injury injury NN cord-015306-us58wwmp 1464 4 and and CC cord-015306-us58wwmp 1464 5 nephrotic nephrotic JJ cord-015306-us58wwmp 1464 6 syndrome syndrome NN cord-015306-us58wwmp 1464 7 were be VBD cord-015306-us58wwmp 1464 8 induced induce VBN cord-015306-us58wwmp 1464 9 by by IN cord-015306-us58wwmp 1464 10 puromycin puromycin NNS cord-015306-us58wwmp 1464 11 aminonucleoside aminonucleoside NNP cord-015306-us58wwmp 1464 12 ( ( -LRB- cord-015306-us58wwmp 1464 13 PAN PAN NNP cord-015306-us58wwmp 1464 14 ) ) -RRB- cord-015306-us58wwmp 1464 15 injection injection NN cord-015306-us58wwmp 1464 16 in in IN cord-015306-us58wwmp 1464 17 rats rat NNS cord-015306-us58wwmp 1464 18 with with IN cord-015306-us58wwmp 1464 19 or or CC cord-015306-us58wwmp 1464 20 without without IN cord-015306-us58wwmp 1464 21 CsA. CsA. NNP cord-015306-us58wwmp 1465 1 Cultured cultured JJ cord-015306-us58wwmp 1465 2 podocytes podocyte NNS cord-015306-us58wwmp 1465 3 were be VBD cord-015306-us58wwmp 1465 4 exposed expose VBN cord-015306-us58wwmp 1465 5 to to IN cord-015306-us58wwmp 1465 6 PAN PAN NNP cord-015306-us58wwmp 1465 7 with with IN cord-015306-us58wwmp 1465 8 or or CC cord-015306-us58wwmp 1465 9 without without IN cord-015306-us58wwmp 1465 10 CsA csa NN cord-015306-us58wwmp 1465 11 treatment treatment NN cord-015306-us58wwmp 1465 12 . . . cord-015306-us58wwmp 1466 1 Cofilin-1 Cofilin-1 NNP cord-015306-us58wwmp 1466 2 , , , cord-015306-us58wwmp 1466 3 nephrin nephrin NNP cord-015306-us58wwmp 1466 4 , , , cord-015306-us58wwmp 1466 5 synaptopodin synaptopodin NNP cord-015306-us58wwmp 1466 6 expression expression NN cord-015306-us58wwmp 1466 7 were be VBD cord-015306-us58wwmp 1466 8 determined determine VBN cord-015306-us58wwmp 1466 9 by by IN cord-015306-us58wwmp 1466 10 western western JJ cord-015306-us58wwmp 1466 11 blot blot NN cord-015306-us58wwmp 1466 12 or or CC cord-015306-us58wwmp 1466 13 immunofluorescence immunofluorescence NN cord-015306-us58wwmp 1466 14 . . . cord-015306-us58wwmp 1467 1 The the DT cord-015306-us58wwmp 1467 2 cofilin-1 cofilin-1 NNP cord-015306-us58wwmp 1467 3 specific specific JJ cord-015306-us58wwmp 1467 4 effect effect NN cord-015306-us58wwmp 1467 5 was be VBD cord-015306-us58wwmp 1467 6 determined determine VBN cord-015306-us58wwmp 1467 7 using use VBG cord-015306-us58wwmp 1467 8 cofilin-1 cofilin-1 NNP cord-015306-us58wwmp 1467 9 siRNA siRNA NNP cord-015306-us58wwmp 1467 10 . . . cord-015306-us58wwmp 1468 1 Results result NNS cord-015306-us58wwmp 1468 2 : : : cord-015306-us58wwmp 1469 1 CsA CsA NNP cord-015306-us58wwmp 1469 2 reduced reduce VBN cord-015306-us58wwmp 1469 3 proteinuria proteinuria NN cord-015306-us58wwmp 1469 4 , , , cord-015306-us58wwmp 1469 5 restored restore VBD cord-015306-us58wwmp 1469 6 expression expression NN cord-015306-us58wwmp 1469 7 of of IN cord-015306-us58wwmp 1469 8 cofilin-1 cofilin-1 NNP cord-015306-us58wwmp 1469 9 , , , cord-015306-us58wwmp 1469 10 nephrin nephrin NNP cord-015306-us58wwmp 1469 11 , , , cord-015306-us58wwmp 1469 12 syanptopodin syanptopodin NNP cord-015306-us58wwmp 1469 13 and and CC cord-015306-us58wwmp 1469 14 repaired repair VBN cord-015306-us58wwmp 1469 15 foot foot NN cord-015306-us58wwmp 1469 16 process process NN cord-015306-us58wwmp 1469 17 effacement effacement NN cord-015306-us58wwmp 1469 18 of of IN cord-015306-us58wwmp 1469 19 PAN PAN NNP cord-015306-us58wwmp 1469 20 induced induce VBN cord-015306-us58wwmp 1469 21 nephropathy nephropathy NN cord-015306-us58wwmp 1469 22 in in IN cord-015306-us58wwmp 1469 23 vivo vivo NN cord-015306-us58wwmp 1469 24 . . . cord-015306-us58wwmp 1470 1 In in IN cord-015306-us58wwmp 1470 2 vitro vitro FW cord-015306-us58wwmp 1470 3 studies study NNS cord-015306-us58wwmp 1470 4 showed show VBD cord-015306-us58wwmp 1470 5 that that IN cord-015306-us58wwmp 1470 6 exposure exposure NN cord-015306-us58wwmp 1470 7 of of IN cord-015306-us58wwmp 1470 8 CsA csa NN cord-015306-us58wwmp 1470 9 restored restore VBD cord-015306-us58wwmp 1470 10 the the DT cord-015306-us58wwmp 1470 11 expression expression NN cord-015306-us58wwmp 1470 12 of of IN cord-015306-us58wwmp 1470 13 cofilin-1 cofilin-1 NNP cord-015306-us58wwmp 1470 14 and and CC cord-015306-us58wwmp 1470 15 nephrin nephrin NNP cord-015306-us58wwmp 1470 16 which which WDT cord-015306-us58wwmp 1470 17 decreased decrease VBD cord-015306-us58wwmp 1470 18 by by IN cord-015306-us58wwmp 1470 19 PAN PAN NNP cord-015306-us58wwmp 1470 20 . . NNP cord-015306-us58wwmp 1470 21 CsA CsA NNP cord-015306-us58wwmp 1470 22 also also RB cord-015306-us58wwmp 1470 23 repaired repair VBD cord-015306-us58wwmp 1470 24 actin actin NN cord-015306-us58wwmp 1470 25 cytoskeleton cytoskeleton NNS cord-015306-us58wwmp 1470 26 impaired impair VBN cord-015306-us58wwmp 1470 27 by by IN cord-015306-us58wwmp 1470 28 PAN PAN NNP cord-015306-us58wwmp 1470 29 . . . cord-015306-us58wwmp 1471 1 The the DT cord-015306-us58wwmp 1471 2 protective protective JJ cord-015306-us58wwmp 1471 3 effect effect NN cord-015306-us58wwmp 1471 4 of of IN cord-015306-us58wwmp 1471 5 CsA csa NN cord-015306-us58wwmp 1471 6 was be VBD cord-015306-us58wwmp 1471 7 disappeared disappear VBN cord-015306-us58wwmp 1471 8 partially partially RB cord-015306-us58wwmp 1471 9 when when WRB cord-015306-us58wwmp 1471 10 cultured cultured JJ cord-015306-us58wwmp 1471 11 podocytes podocyte NNS cord-015306-us58wwmp 1471 12 were be VBD cord-015306-us58wwmp 1471 13 exposed expose VBN cord-015306-us58wwmp 1471 14 to to IN cord-015306-us58wwmp 1471 15 cofilin-1 cofilin-1 NNP cord-015306-us58wwmp 1471 16 siRNA siRNA NNP cord-015306-us58wwmp 1471 17 . . . cord-015306-us58wwmp 1472 1 Objective objective NN cord-015306-us58wwmp 1472 2 : : : cord-015306-us58wwmp 1473 1 To to TO cord-015306-us58wwmp 1473 2 find find VB cord-015306-us58wwmp 1473 3 a a DT cord-015306-us58wwmp 1473 4 probably probably RB cord-015306-us58wwmp 1473 5 mechanism mechanism NN cord-015306-us58wwmp 1473 6 of of IN cord-015306-us58wwmp 1473 7 immune immune JJ cord-015306-us58wwmp 1473 8 disorder disorder NN cord-015306-us58wwmp 1473 9 in in IN cord-015306-us58wwmp 1473 10 RSV RSV NNP cord-015306-us58wwmp 1473 11 nephropathy nephropathy NN cord-015306-us58wwmp 1473 12 in in IN cord-015306-us58wwmp 1473 13 rats rat NNS cord-015306-us58wwmp 1473 14 which which WDT cord-015306-us58wwmp 1473 15 resembled resemble VBD cord-015306-us58wwmp 1473 16 the the DT cord-015306-us58wwmp 1473 17 change change NN cord-015306-us58wwmp 1473 18 of of IN cord-015306-us58wwmp 1473 19 minimal minimal JJ cord-015306-us58wwmp 1473 20 change change NN cord-015306-us58wwmp 1473 21 nephrotic nephrotic JJ cord-015306-us58wwmp 1473 22 syndrome syndrome NN cord-015306-us58wwmp 1473 23 . . . cord-015306-us58wwmp 1474 1 Methods method NNS cord-015306-us58wwmp 1474 2 : : : cord-015306-us58wwmp 1474 3 1 1 CD cord-015306-us58wwmp 1474 4 . . . cord-015306-us58wwmp 1475 1 RSV RSV NNP cord-015306-us58wwmp 1475 2 mRNAs mrnas XX cord-015306-us58wwmp 1476 1 ( ( -LRB- cord-015306-us58wwmp 1476 2 G G NNP cord-015306-us58wwmp 1476 3 , , , cord-015306-us58wwmp 1476 4 F F NNP cord-015306-us58wwmp 1476 5 , , , cord-015306-us58wwmp 1476 6 M2 M2 NNP cord-015306-us58wwmp 1476 7 , , , cord-015306-us58wwmp 1476 8 NS1 NS1 NNP cord-015306-us58wwmp 1476 9 , , , cord-015306-us58wwmp 1476 10 NS2 NS2 NNP cord-015306-us58wwmp 1476 11 ) ) -RRB- cord-015306-us58wwmp 1476 12 and and CC cord-015306-us58wwmp 1476 13 proteins protein NNS cord-015306-us58wwmp 1476 14 ( ( -LRB- cord-015306-us58wwmp 1476 15 G G NNP cord-015306-us58wwmp 1476 16 and and CC cord-015306-us58wwmp 1476 17 F F NNP cord-015306-us58wwmp 1476 18 ) ) -RRB- cord-015306-us58wwmp 1476 19 were be VBD cord-015306-us58wwmp 1476 20 detected detect VBN cord-015306-us58wwmp 1476 21 with with IN cord-015306-us58wwmp 1476 22 fluorogenic fluorogenic JJ cord-015306-us58wwmp 1476 23 quantitative quantitative JJ cord-015306-us58wwmp 1476 24 RT RT NNP cord-015306-us58wwmp 1476 25 - - HYPH cord-015306-us58wwmp 1476 26 PCR PCR NNP cord-015306-us58wwmp 1476 27 and and CC cord-015306-us58wwmp 1476 28 indirect indirect JJ cord-015306-us58wwmp 1476 29 immunofluorescence immunofluorescence NN cord-015306-us58wwmp 1476 30 assay assay NN cord-015306-us58wwmp 1476 31 ( ( -LRB- cord-015306-us58wwmp 1476 32 IFA IFA NNP cord-015306-us58wwmp 1476 33 ) ) -RRB- cord-015306-us58wwmp 1476 34 to to TO cord-015306-us58wwmp 1476 35 find find VB cord-015306-us58wwmp 1476 36 the the DT cord-015306-us58wwmp 1476 37 evidence evidence NN cord-015306-us58wwmp 1476 38 of of IN cord-015306-us58wwmp 1476 39 viral viral JJ cord-015306-us58wwmp 1476 40 persistence persistence NN cord-015306-us58wwmp 1476 41 . . . cord-015306-us58wwmp 1477 1 2 2 LS cord-015306-us58wwmp 1477 2 . . . cord-015306-us58wwmp 1478 1 DC DC NNP cord-015306-us58wwmp 1478 2 - - HYPH cord-015306-us58wwmp 1478 3 SIGN SIGN NNP cord-015306-us58wwmp 1478 4 mRNA mrna NN cord-015306-us58wwmp 1478 5 and and CC cord-015306-us58wwmp 1478 6 protein protein NN cord-015306-us58wwmp 1478 7 were be VBD cord-015306-us58wwmp 1478 8 detected detect VBN cord-015306-us58wwmp 1478 9 with with IN cord-015306-us58wwmp 1478 10 RT RT NNP cord-015306-us58wwmp 1478 11 - - HYPH cord-015306-us58wwmp 1478 12 PCR PCR NNP cord-015306-us58wwmp 1478 13 and and CC cord-015306-us58wwmp 1478 14 IFA IFA NNP cord-015306-us58wwmp 1478 15 to to TO cord-015306-us58wwmp 1478 16 find find VB cord-015306-us58wwmp 1478 17 the the DT cord-015306-us58wwmp 1478 18 trend trend NN cord-015306-us58wwmp 1478 19 of of IN cord-015306-us58wwmp 1478 20 its -PRON- PRP$ cord-015306-us58wwmp 1478 21 change change NN cord-015306-us58wwmp 1478 22 . . . cord-015306-us58wwmp 1479 1 3 3 LS cord-015306-us58wwmp 1479 2 . . . cord-015306-us58wwmp 1480 1 The the DT cord-015306-us58wwmp 1480 2 levels level NNS cord-015306-us58wwmp 1480 3 of of IN cord-015306-us58wwmp 1480 4 IL-12 IL-12 NNP cord-015306-us58wwmp 1480 5 / / SYM cord-015306-us58wwmp 1480 6 IL-10 IL-10 NNP cord-015306-us58wwmp 1480 7 and and CC cord-015306-us58wwmp 1480 8 CD4 CD4 NNP cord-015306-us58wwmp 1480 9 / / SYM cord-015306-us58wwmp 1480 10 CD8 CD8 NNP cord-015306-us58wwmp 1480 11 were be VBD cord-015306-us58wwmp 1480 12 measured measure VBN cord-015306-us58wwmp 1480 13 by by IN cord-015306-us58wwmp 1480 14 ELISA ELISA NNP cord-015306-us58wwmp 1480 15 and and CC cord-015306-us58wwmp 1480 16 flowcytometry flowcytometry NNP cord-015306-us58wwmp 1480 17 . . . cord-015306-us58wwmp 1481 1 Results result NNS cord-015306-us58wwmp 1481 2 : : : cord-015306-us58wwmp 1482 1 The the DT cord-015306-us58wwmp 1482 2 course course NN cord-015306-us58wwmp 1482 3 could could MD cord-015306-us58wwmp 1482 4 be be VB cord-015306-us58wwmp 1482 5 divided divide VBN cord-015306-us58wwmp 1482 6 into into IN cord-015306-us58wwmp 1482 7 two two CD cord-015306-us58wwmp 1482 8 stages stage NNS cord-015306-us58wwmp 1482 9 : : : cord-015306-us58wwmp 1482 10 1 1 CD cord-015306-us58wwmp 1482 11 . . . cord-015306-us58wwmp 1483 1 First first JJ cord-015306-us58wwmp 1483 2 stage stage NN cord-015306-us58wwmp 1483 3 ( ( -LRB- cord-015306-us58wwmp 1483 4 4d-14d 4d-14d CD cord-015306-us58wwmp 1483 5 ) ) -RRB- cord-015306-us58wwmp 1484 1 The the DT cord-015306-us58wwmp 1484 2 mRNA mrna NN cord-015306-us58wwmp 1484 3 of of IN cord-015306-us58wwmp 1484 4 RSV RSV NNP cord-015306-us58wwmp 1484 5 F F NNP cord-015306-us58wwmp 1484 6 , , , cord-015306-us58wwmp 1484 7 G G NNP cord-015306-us58wwmp 1484 8 , , , cord-015306-us58wwmp 1484 9 M2 M2 NNP cord-015306-us58wwmp 1484 10 , , , cord-015306-us58wwmp 1485 1 NS-1 NS-1 NNP cord-015306-us58wwmp 1485 2 and and CC cord-015306-us58wwmp 1485 3 NS-2 NS-2 NNP cord-015306-us58wwmp 1485 4 in in IN cord-015306-us58wwmp 1485 5 kidneys kidney NNS cord-015306-us58wwmp 1485 6 , , , cord-015306-us58wwmp 1485 7 lungs lung NNS cord-015306-us58wwmp 1485 8 and and CC cord-015306-us58wwmp 1485 9 spleens spleen NNS cord-015306-us58wwmp 1485 10 expressed express VBN cord-015306-us58wwmp 1485 11 and and CC cord-015306-us58wwmp 1485 12 arrived arrive VBD cord-015306-us58wwmp 1485 13 at at IN cord-015306-us58wwmp 1485 14 the the DT cord-015306-us58wwmp 1485 15 highest high JJS cord-015306-us58wwmp 1485 16 on on IN cord-015306-us58wwmp 1485 17 14d 14d NNS cord-015306-us58wwmp 1485 18 , , , cord-015306-us58wwmp 1485 19 which which WDT cord-015306-us58wwmp 1485 20 accorded accord VBN cord-015306-us58wwmp 1485 21 with with IN cord-015306-us58wwmp 1485 22 the the DT cord-015306-us58wwmp 1485 23 expression expression NN cord-015306-us58wwmp 1485 24 of of IN cord-015306-us58wwmp 1485 25 RSV RSV NNP cord-015306-us58wwmp 1485 26 F F NNP cord-015306-us58wwmp 1485 27 and and CC cord-015306-us58wwmp 1485 28 G G NNP cord-015306-us58wwmp 1485 29 proteins protein NNS cord-015306-us58wwmp 1485 30 in in IN cord-015306-us58wwmp 1485 31 IFA IFA NNP cord-015306-us58wwmp 1485 32 . . . cord-015306-us58wwmp 1486 1 The the DT cord-015306-us58wwmp 1486 2 positively positively RB cord-015306-us58wwmp 1486 3 fluorescent fluorescent JJ cord-015306-us58wwmp 1486 4 luminance luminance NN cord-015306-us58wwmp 1486 5 and and CC cord-015306-us58wwmp 1486 6 mRNA mrna NN cord-015306-us58wwmp 1486 7 of of IN cord-015306-us58wwmp 1486 8 DC DC NNP cord-015306-us58wwmp 1486 9 - - HYPH cord-015306-us58wwmp 1486 10 SIGN SIGN NNP cord-015306-us58wwmp 1486 11 expressed express VBD cord-015306-us58wwmp 1486 12 stronger strong JJR cord-015306-us58wwmp 1486 13 than than IN cord-015306-us58wwmp 1486 14 that that DT cord-015306-us58wwmp 1486 15 in in IN cord-015306-us58wwmp 1486 16 the the DT cord-015306-us58wwmp 1486 17 control control NN cord-015306-us58wwmp 1486 18 , , , cord-015306-us58wwmp 1486 19 especially especially RB cord-015306-us58wwmp 1486 20 from from IN cord-015306-us58wwmp 1486 21 8d 8d NNP cord-015306-us58wwmp 1486 22 ( ( -LRB- cord-015306-us58wwmp 1486 23 Ct Ct NNP cord-015306-us58wwmp 1486 24 kidney kidney NN cord-015306-us58wwmp 1486 25 = = SYM cord-015306-us58wwmp 1486 26 18.50±3.12 18.50±3.12 CD cord-015306-us58wwmp 1486 27 ) ) -RRB- cord-015306-us58wwmp 1486 28 to to IN cord-015306-us58wwmp 1486 29 14d 14d NNS cord-015306-us58wwmp 1487 1 ( ( -LRB- cord-015306-us58wwmp 1487 2 Ct ct JJ cord-015306-us58wwmp 1487 3 kidney kidney NN cord-015306-us58wwmp 1487 4 = = SYM cord-015306-us58wwmp 1487 5 11.40±2.07 11.40±2.07 CD cord-015306-us58wwmp 1487 6 ) ) -RRB- cord-015306-us58wwmp 1487 7 . . . cord-015306-us58wwmp 1488 1 Compared compare VBN cord-015306-us58wwmp 1488 2 with with IN cord-015306-us58wwmp 1488 3 the the DT cord-015306-us58wwmp 1488 4 control control NN cord-015306-us58wwmp 1488 5 , , , cord-015306-us58wwmp 1488 6 the the DT cord-015306-us58wwmp 1488 7 secretion secretion NN cord-015306-us58wwmp 1488 8 of of IN cord-015306-us58wwmp 1488 9 IL-12 IL-12 NNP cord-015306-us58wwmp 1488 10 in in IN cord-015306-us58wwmp 1488 11 renal renal JJ cord-015306-us58wwmp 1488 12 tissues tissue NNS cord-015306-us58wwmp 1488 13 was be VBD cord-015306-us58wwmp 1488 14 rising rise VBG cord-015306-us58wwmp 1488 15 from from IN cord-015306-us58wwmp 1488 16 4d 4d CD cord-015306-us58wwmp 1488 17 ( ( -LRB- cord-015306-us58wwmp 1488 18 1205.46±262.07pg 1205.46±262.07pg CD cord-015306-us58wwmp 1488 19 / / SYM cord-015306-us58wwmp 1488 20 ml ml NN cord-015306-us58wwmp 1488 21 ) ) -RRB- cord-015306-us58wwmp 1488 22 to to IN cord-015306-us58wwmp 1488 23 14d 14d NNS cord-015306-us58wwmp 1489 1 ( ( -LRB- cord-015306-us58wwmp 1489 2 1054.68±154.18pg 1054.68±154.18pg CD cord-015306-us58wwmp 1489 3 / / SYM cord-015306-us58wwmp 1489 4 ml ml NN cord-015306-us58wwmp 1489 5 ) ) -RRB- cord-015306-us58wwmp 1489 6 . . . cord-015306-us58wwmp 1490 1 The the DT cord-015306-us58wwmp 1490 2 expression expression NN cord-015306-us58wwmp 1490 3 of of IN cord-015306-us58wwmp 1490 4 CD4 CD4 NNP cord-015306-us58wwmp 1490 5 and and CC cord-015306-us58wwmp 1490 6 CD8 CD8 NNP cord-015306-us58wwmp 1490 7 in in IN cord-015306-us58wwmp 1490 8 peripheral peripheral JJ cord-015306-us58wwmp 1490 9 blood blood NN cord-015306-us58wwmp 1490 10 was be VBD cord-015306-us58wwmp 1490 11 lower low JJR cord-015306-us58wwmp 1490 12 than than IN cord-015306-us58wwmp 1490 13 that that DT cord-015306-us58wwmp 1490 14 in in IN cord-015306-us58wwmp 1490 15 normal normal JJ cord-015306-us58wwmp 1490 16 control control NN cord-015306-us58wwmp 1490 17 . . . cord-015306-us58wwmp 1491 1 2 2 LS cord-015306-us58wwmp 1491 2 . . . cord-015306-us58wwmp 1492 1 Second second JJ cord-015306-us58wwmp 1492 2 stage stage NN cord-015306-us58wwmp 1492 3 ( ( -LRB- cord-015306-us58wwmp 1492 4 30d-120d 30d-120d NFP cord-015306-us58wwmp 1492 5 ) ) -RRB- cord-015306-us58wwmp 1492 6 RSV RSV NNP cord-015306-us58wwmp 1492 7 mRNA mRNA NNP cord-015306-us58wwmp 1492 8 and and CC cord-015306-us58wwmp 1492 9 viral viral JJ cord-015306-us58wwmp 1492 10 proteins protein NNS cord-015306-us58wwmp 1492 11 in in IN cord-015306-us58wwmp 1492 12 the the DT cord-015306-us58wwmp 1492 13 tissues tissue NNS cord-015306-us58wwmp 1492 14 were be VBD cord-015306-us58wwmp 1492 15 persistently persistently RB cord-015306-us58wwmp 1492 16 expressed express VBN cord-015306-us58wwmp 1492 17 ; ; : cord-015306-us58wwmp 1492 18 it -PRON- PRP cord-015306-us58wwmp 1492 19 showed show VBD cord-015306-us58wwmp 1492 20 that that IN cord-015306-us58wwmp 1492 21 partial partial JJ cord-015306-us58wwmp 1492 22 RSV RSV NNP cord-015306-us58wwmp 1492 23 survived survive VBD cord-015306-us58wwmp 1492 24 through through IN cord-015306-us58wwmp 1492 25 immune immune JJ cord-015306-us58wwmp 1492 26 escape escape NN cord-015306-us58wwmp 1492 27 . . . cord-015306-us58wwmp 1493 1 After after IN cord-015306-us58wwmp 1493 2 30d 30d CD cord-015306-us58wwmp 1493 3 , , , cord-015306-us58wwmp 1493 4 the the DT cord-015306-us58wwmp 1493 5 fluorescent fluorescent NN cord-015306-us58wwmp 1493 6 luminance luminance NN cord-015306-us58wwmp 1493 7 of of IN cord-015306-us58wwmp 1493 8 DC DC NNP cord-015306-us58wwmp 1493 9 - - HYPH cord-015306-us58wwmp 1493 10 SIGN SIGN NNP cord-015306-us58wwmp 1493 11 was be VBD cord-015306-us58wwmp 1493 12 gradually gradually RB cord-015306-us58wwmp 1493 13 reduced reduce VBN cord-015306-us58wwmp 1493 14 in in IN cord-015306-us58wwmp 1493 15 the the DT cord-015306-us58wwmp 1493 16 three three CD cord-015306-us58wwmp 1493 17 tissues tissue NNS cord-015306-us58wwmp 1493 18 . . . cord-015306-us58wwmp 1494 1 The the DT cord-015306-us58wwmp 1494 2 expression expression NN cord-015306-us58wwmp 1494 3 of of IN cord-015306-us58wwmp 1494 4 DC DC NNP cord-015306-us58wwmp 1494 5 - - HYPH cord-015306-us58wwmp 1494 6 SIGN SIGN NNP cord-015306-us58wwmp 1494 7 mRNA mrna NN cord-015306-us58wwmp 1494 8 in in IN cord-015306-us58wwmp 1494 9 kidneys kidney NNS cord-015306-us58wwmp 1494 10 , , , cord-015306-us58wwmp 1494 11 lungs lung NNS cord-015306-us58wwmp 1494 12 and and CC cord-015306-us58wwmp 1494 13 spleens spleen NNS cord-015306-us58wwmp 1494 14 on on IN cord-015306-us58wwmp 1494 15 60d 60d NNS cord-015306-us58wwmp 1495 1 ( ( -LRB- cord-015306-us58wwmp 1495 2 Ct ct JJ cord-015306-us58wwmp 1495 3 kidney kidney NN cord-015306-us58wwmp 1495 4 = = SYM cord-015306-us58wwmp 1495 5 14.10±8.32 14.10±8.32 CD cord-015306-us58wwmp 1495 6 ) ) -RRB- cord-015306-us58wwmp 1495 7 and and CC cord-015306-us58wwmp 1495 8 120d 120d NNP cord-015306-us58wwmp 1495 9 ( ( -LRB- cord-015306-us58wwmp 1495 10 Ct ct JJ cord-015306-us58wwmp 1495 11 kidney kidney NN cord-015306-us58wwmp 1495 12 = = SYM cord-015306-us58wwmp 1495 13 14.92±1.80 14.92±1.80 CD cord-015306-us58wwmp 1495 14 ) ) -RRB- cord-015306-us58wwmp 1495 15 was be VBD cord-015306-us58wwmp 1495 16 higher high JJR cord-015306-us58wwmp 1495 17 , , , cord-015306-us58wwmp 1495 18 except except IN cord-015306-us58wwmp 1495 19 that that IN cord-015306-us58wwmp 1495 20 in in IN cord-015306-us58wwmp 1495 21 spleens spleen NNS cord-015306-us58wwmp 1495 22 on on IN cord-015306-us58wwmp 1495 23 30d 30d NNS cord-015306-us58wwmp 1495 24 ( ( -LRB- cord-015306-us58wwmp 1495 25 Ct= Ct= NNP cord-015306-us58wwmp 1495 26 21.90±1.43 21.90±1.43 CD cord-015306-us58wwmp 1495 27 ) ) -RRB- cord-015306-us58wwmp 1495 28 was be VBD cord-015306-us58wwmp 1495 29 significantly significantly RB cord-015306-us58wwmp 1495 30 lower low JJR cord-015306-us58wwmp 1495 31 than than IN cord-015306-us58wwmp 1495 32 the the DT cord-015306-us58wwmp 1495 33 control control NN cord-015306-us58wwmp 1495 34 . . . cord-015306-us58wwmp 1496 1 The the DT cord-015306-us58wwmp 1496 2 secretion secretion NN cord-015306-us58wwmp 1496 3 of of IN cord-015306-us58wwmp 1496 4 IL-12 IL-12 NNP cord-015306-us58wwmp 1496 5 in in IN cord-015306-us58wwmp 1496 6 tissues tissue NNS cord-015306-us58wwmp 1496 7 decreased decrease VBD cord-015306-us58wwmp 1496 8 after after IN cord-015306-us58wwmp 1496 9 30d 30d NNS cord-015306-us58wwmp 1496 10 ( ( -LRB- cord-015306-us58wwmp 1496 11 583.40±199.26pg 583.40±199.26pg NN cord-015306-us58wwmp 1496 12 / / SYM cord-015306-us58wwmp 1496 13 ml ml NN cord-015306-us58wwmp 1496 14 ) ) -RRB- cord-015306-us58wwmp 1496 15 , , , cord-015306-us58wwmp 1496 16 but but CC cord-015306-us58wwmp 1496 17 that that DT cord-015306-us58wwmp 1496 18 of of IN cord-015306-us58wwmp 1496 19 IL-10 IL-10 NNP cord-015306-us58wwmp 1496 20 gradully gradully RB cord-015306-us58wwmp 1496 21 increased increase VBD cord-015306-us58wwmp 1496 22 after after IN cord-015306-us58wwmp 1496 23 30d 30d NNPS cord-015306-us58wwmp 1496 24 ( ( -LRB- cord-015306-us58wwmp 1496 25 3832.38±88.20pg 3832.38±88.20pg CD cord-015306-us58wwmp 1496 26 / / SYM cord-015306-us58wwmp 1496 27 ml ml NN cord-015306-us58wwmp 1496 28 ) ) -RRB- cord-015306-us58wwmp 1496 29 . . . cord-015306-us58wwmp 1497 1 Although although IN cord-015306-us58wwmp 1497 2 the the DT cord-015306-us58wwmp 1497 3 expression expression NN cord-015306-us58wwmp 1497 4 of of IN cord-015306-us58wwmp 1497 5 CD4 CD4 NNP cord-015306-us58wwmp 1497 6 and and CC cord-015306-us58wwmp 1497 7 CD8 CD8 NNP cord-015306-us58wwmp 1497 8 in in IN cord-015306-us58wwmp 1497 9 peripheral peripheral JJ cord-015306-us58wwmp 1497 10 blood blood NN cord-015306-us58wwmp 1497 11 was be VBD cord-015306-us58wwmp 1497 12 increased increase VBN cord-015306-us58wwmp 1497 13 gradually gradually RB cord-015306-us58wwmp 1497 14 after after IN cord-015306-us58wwmp 1497 15 inoculation inoculation NN cord-015306-us58wwmp 1497 16 , , , cord-015306-us58wwmp 1497 17 the the DT cord-015306-us58wwmp 1497 18 level level NN cord-015306-us58wwmp 1497 19 was be VBD cord-015306-us58wwmp 1497 20 still still RB cord-015306-us58wwmp 1497 21 lower low JJR cord-015306-us58wwmp 1497 22 than than IN cord-015306-us58wwmp 1497 23 that that DT cord-015306-us58wwmp 1497 24 in in IN cord-015306-us58wwmp 1497 25 normal normal JJ cord-015306-us58wwmp 1497 26 control control NN cord-015306-us58wwmp 1497 27 . . . cord-015306-us58wwmp 1498 1 Conclusion conclusion NN cord-015306-us58wwmp 1498 2 : : : cord-015306-us58wwmp 1499 1 There there EX cord-015306-us58wwmp 1499 2 was be VBD cord-015306-us58wwmp 1499 3 RSV RSV NNP cord-015306-us58wwmp 1499 4 persistence persistence NN cord-015306-us58wwmp 1499 5 in in IN cord-015306-us58wwmp 1499 6 rats rat NNS cord-015306-us58wwmp 1499 7 which which WDT cord-015306-us58wwmp 1499 8 likely likely RB cord-015306-us58wwmp 1499 9 attributed attribute VBD cord-015306-us58wwmp 1499 10 to to IN cord-015306-us58wwmp 1499 11 the the DT cord-015306-us58wwmp 1499 12 RSV RSV NNP cord-015306-us58wwmp 1499 13 - - HYPH cord-015306-us58wwmp 1499 14 induced induce VBN cord-015306-us58wwmp 1499 15 immune immune JJ cord-015306-us58wwmp 1499 16 escape escape NN cord-015306-us58wwmp 1499 17 . . . cord-015306-us58wwmp 1500 1 RSV RSV NNP cord-015306-us58wwmp 1500 2 interacts interact VBZ cord-015306-us58wwmp 1500 3 with with IN cord-015306-us58wwmp 1500 4 DC DC NNP cord-015306-us58wwmp 1500 5 - - HYPH cord-015306-us58wwmp 1500 6 SIGN SIGN NNP cord-015306-us58wwmp 1500 7 to to TO cord-015306-us58wwmp 1500 8 make make VB cord-015306-us58wwmp 1500 9 DCs DCs NNP cord-015306-us58wwmp 1500 10 inhibit inhibit VB cord-015306-us58wwmp 1500 11 the the DT cord-015306-us58wwmp 1500 12 immune immune JJ cord-015306-us58wwmp 1500 13 ability ability NN cord-015306-us58wwmp 1500 14 of of IN cord-015306-us58wwmp 1500 15 cytotoxic cytotoxic JJ cord-015306-us58wwmp 1500 16 T t NN cord-015306-us58wwmp 1500 17 cells cell NNS cord-015306-us58wwmp 1500 18 , , , cord-015306-us58wwmp 1500 19 caused cause VBD cord-015306-us58wwmp 1500 20 T t NN cord-015306-us58wwmp 1500 21 cell cell NN cord-015306-us58wwmp 1500 22 immune immune JJ cord-015306-us58wwmp 1500 23 dysfunction dysfunction NN cord-015306-us58wwmp 1500 24 and and CC cord-015306-us58wwmp 1500 25 finally finally RB cord-015306-us58wwmp 1500 26 induced induce VBD cord-015306-us58wwmp 1500 27 the the DT cord-015306-us58wwmp 1500 28 immune immune JJ cord-015306-us58wwmp 1500 29 tolerance tolerance NN cord-015306-us58wwmp 1500 30 . . . cord-015306-us58wwmp 1501 1 Abstract abstract JJ cord-015306-us58wwmp 1501 2 # # NN cord-015306-us58wwmp 1501 3 P p NN cord-015306-us58wwmp 1501 4 - - HYPH cord-015306-us58wwmp 1501 5 SAT185 SAT185 NNP cord-015306-us58wwmp 1501 6 Evaluation Evaluation NNP cord-015306-us58wwmp 1501 7 of of IN cord-015306-us58wwmp 1501 8 the the DT cord-015306-us58wwmp 1501 9 migratory migratory JJ cord-015306-us58wwmp 1501 10 and and CC cord-015306-us58wwmp 1501 11 regulatory regulatory JJ cord-015306-us58wwmp 1501 12 profile profile NN cord-015306-us58wwmp 1501 13 of of IN cord-015306-us58wwmp 1501 14 leukocytes leukocyte NNS cord-015306-us58wwmp 1501 15 from from IN cord-015306-us58wwmp 1501 16 peripheral peripheral JJ cord-015306-us58wwmp 1501 17 blood blood NN cord-015306-us58wwmp 1501 18 in in IN cord-015306-us58wwmp 1501 19 pediatric pediatric JJ cord-015306-us58wwmp 1501 20 patients patient NNS cord-015306-us58wwmp 1501 21 with with IN cord-015306-us58wwmp 1501 22 idiopathic idiopathic JJ cord-015306-us58wwmp 1501 23 nephrotic nephrotic JJ cord-015306-us58wwmp 1501 24 syndrome syndrome NN cord-015306-us58wwmp 1501 25 Objective objective NN cord-015306-us58wwmp 1501 26 : : : cord-015306-us58wwmp 1501 27 Dynamic dynamic JJ cord-015306-us58wwmp 1501 28 regulation regulation NN cord-015306-us58wwmp 1501 29 of of IN cord-015306-us58wwmp 1501 30 the the DT cord-015306-us58wwmp 1501 31 podocyte podocyte NNP cord-015306-us58wwmp 1502 1 cytoskeleton cytoskeleton NN cord-015306-us58wwmp 1502 2 plays play VBZ cord-015306-us58wwmp 1502 3 an an DT cord-015306-us58wwmp 1502 4 important important JJ cord-015306-us58wwmp 1502 5 role role NN cord-015306-us58wwmp 1502 6 in in IN cord-015306-us58wwmp 1502 7 maintaining maintain VBG cord-015306-us58wwmp 1502 8 the the DT cord-015306-us58wwmp 1502 9 glomerular glomerular JJ cord-015306-us58wwmp 1502 10 filtration filtration NN cord-015306-us58wwmp 1502 11 barrier barrier NN cord-015306-us58wwmp 1502 12 . . . cord-015306-us58wwmp 1503 1 Severe severe JJ cord-015306-us58wwmp 1503 2 glomerular glomerular JJ cord-015306-us58wwmp 1503 3 disorders disorder NNS cord-015306-us58wwmp 1503 4 are be VBP cord-015306-us58wwmp 1503 5 associated associate VBN cord-015306-us58wwmp 1503 6 with with IN cord-015306-us58wwmp 1503 7 perturbed perturbed JJ cord-015306-us58wwmp 1503 8 organization organization NN cord-015306-us58wwmp 1503 9 of of IN cord-015306-us58wwmp 1503 10 the the DT cord-015306-us58wwmp 1503 11 podocyte podocyte NNP cord-015306-us58wwmp 1503 12 actin actin NNP cord-015306-us58wwmp 1503 13 cytoskeleton cytoskeleton NNP cord-015306-us58wwmp 1503 14 . . . cord-015306-us58wwmp 1504 1 The the DT cord-015306-us58wwmp 1504 2 therapy therapy NN cord-015306-us58wwmp 1504 3 is be VBZ cord-015306-us58wwmp 1504 4 based base VBN cord-015306-us58wwmp 1504 5 on on IN cord-015306-us58wwmp 1504 6 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 1504 7 agents agent NNS cord-015306-us58wwmp 1504 8 , , , cord-015306-us58wwmp 1504 9 in in IN cord-015306-us58wwmp 1504 10 particular particular JJ cord-015306-us58wwmp 1504 11 cyclosporine cyclosporine NN cord-015306-us58wwmp 1504 12 A a NN cord-015306-us58wwmp 1504 13 , , , cord-015306-us58wwmp 1504 14 whose whose WP$ cord-015306-us58wwmp 1504 15 beneficial beneficial JJ cord-015306-us58wwmp 1504 16 effect effect NN cord-015306-us58wwmp 1504 17 seems seem VBZ cord-015306-us58wwmp 1504 18 also also RB cord-015306-us58wwmp 1504 19 related relate VBN cord-015306-us58wwmp 1504 20 to to IN cord-015306-us58wwmp 1504 21 the the DT cord-015306-us58wwmp 1504 22 stabilization stabilization NN cord-015306-us58wwmp 1504 23 of of IN cord-015306-us58wwmp 1504 24 the the DT cord-015306-us58wwmp 1504 25 actin actin NN cord-015306-us58wwmp 1504 26 cytoskeleton cytoskeleton NN cord-015306-us58wwmp 1504 27 in in IN cord-015306-us58wwmp 1504 28 podocytes podocyte NNS cord-015306-us58wwmp 1504 29 . . . cord-015306-us58wwmp 1505 1 Previous previous JJ cord-015306-us58wwmp 1505 2 studies study NNS cord-015306-us58wwmp 1505 3 of of IN cord-015306-us58wwmp 1505 4 our -PRON- PRP$ cord-015306-us58wwmp 1505 5 group group NN cord-015306-us58wwmp 1505 6 demonstrated demonstrate VBD cord-015306-us58wwmp 1505 7 , , , cord-015306-us58wwmp 1505 8 that that IN cord-015306-us58wwmp 1505 9 the the DT cord-015306-us58wwmp 1505 10 mTOR mTOR NNP cord-015306-us58wwmp 1505 11 inhibitor inhibitor NN cord-015306-us58wwmp 1505 12 everolimus everolimus NNP cord-015306-us58wwmp 1505 13 ( ( -LRB- cord-015306-us58wwmp 1505 14 EV EV NNP cord-015306-us58wwmp 1505 15 ) ) -RRB- cord-015306-us58wwmp 1505 16 might may MD cord-015306-us58wwmp 1505 17 similarly similarly RB cord-015306-us58wwmp 1505 18 involve involve VB cord-015306-us58wwmp 1505 19 the the DT cord-015306-us58wwmp 1505 20 recovery recovery NN cord-015306-us58wwmp 1505 21 of of IN cord-015306-us58wwmp 1505 22 the the DT cord-015306-us58wwmp 1505 23 actin actin NN cord-015306-us58wwmp 1505 24 cytoskeleton cytoskeleton NN cord-015306-us58wwmp 1505 25 in in IN cord-015306-us58wwmp 1505 26 a a DT cord-015306-us58wwmp 1505 27 puromycin puromycin NNS cord-015306-us58wwmp 1505 28 ( ( -LRB- cord-015306-us58wwmp 1505 29 PAN PAN NNP cord-015306-us58wwmp 1505 30 ) ) -RRB- cord-015306-us58wwmp 1505 31 experimental experimental JJ cord-015306-us58wwmp 1505 32 model model NN cord-015306-us58wwmp 1505 33 of of IN cord-015306-us58wwmp 1505 34 proteinuric proteinuric JJ cord-015306-us58wwmp 1505 35 disease disease NN cord-015306-us58wwmp 1505 36 . . . cord-015306-us58wwmp 1506 1 Methods method NNS cord-015306-us58wwmp 1506 2 : : : cord-015306-us58wwmp 1506 3 In in IN cord-015306-us58wwmp 1506 4 the the DT cord-015306-us58wwmp 1506 5 present present JJ cord-015306-us58wwmp 1506 6 study study NN cord-015306-us58wwmp 1506 7 , , , cord-015306-us58wwmp 1506 8 inhibitory inhibitory JJ cord-015306-us58wwmp 1506 9 effects effect NNS cord-015306-us58wwmp 1506 10 of of IN cord-015306-us58wwmp 1506 11 EV EV NNP cord-015306-us58wwmp 1506 12 on on IN cord-015306-us58wwmp 1506 13 mTOR mTOR NNP cord-015306-us58wwmp 1506 14 complex complex NNP cord-015306-us58wwmp 1506 15 1 1 CD cord-015306-us58wwmp 1506 16 ( ( -LRB- cord-015306-us58wwmp 1506 17 mTORC1 mtorc1 NN cord-015306-us58wwmp 1506 18 ) ) -RRB- cord-015306-us58wwmp 1506 19 and and CC cord-015306-us58wwmp 1506 20 −2 −2 NNP cord-015306-us58wwmp 1506 21 ( ( -LRB- cord-015306-us58wwmp 1506 22 mTORC2 mTORC2 NNP cord-015306-us58wwmp 1506 23 ) ) -RRB- cord-015306-us58wwmp 1506 24 were be VBD cord-015306-us58wwmp 1506 25 analyzed analyze VBN cord-015306-us58wwmp 1506 26 by by IN cord-015306-us58wwmp 1506 27 western western JJ cord-015306-us58wwmp 1506 28 blotting blotting NN cord-015306-us58wwmp 1506 29 in in IN cord-015306-us58wwmp 1506 30 human human JJ cord-015306-us58wwmp 1506 31 differentiated differentiated JJ cord-015306-us58wwmp 1506 32 podocytes podocyte NNS cord-015306-us58wwmp 1506 33 . . . cord-015306-us58wwmp 1507 1 Downstream downstream IN cord-015306-us58wwmp 1507 2 of of IN cord-015306-us58wwmp 1507 3 mTORC2 mTORC2 JJS cord-015306-us58wwmp 1507 4 the the DT cord-015306-us58wwmp 1507 5 activity activity NN cord-015306-us58wwmp 1507 6 of of IN cord-015306-us58wwmp 1507 7 RhoA RhoA NNP cord-015306-us58wwmp 1508 1 ( ( -LRB- cord-015306-us58wwmp 1508 2 GTPase GTPase NNP cord-015306-us58wwmp 1508 3 pull pull VB cord-015306-us58wwmp 1508 4 - - HYPH cord-015306-us58wwmp 1508 5 down down RP cord-015306-us58wwmp 1508 6 assay assay NN cord-015306-us58wwmp 1508 7 ) ) -RRB- cord-015306-us58wwmp 1508 8 and and CC cord-015306-us58wwmp 1508 9 myosin myosin NN cord-015306-us58wwmp 1508 10 light light JJ cord-015306-us58wwmp 1508 11 chain chain NN cord-015306-us58wwmp 1508 12 ( ( -LRB- cord-015306-us58wwmp 1508 13 MLC MLC NNP cord-015306-us58wwmp 1508 14 ) ) -RRB- cord-015306-us58wwmp 1508 15 was be VBD cord-015306-us58wwmp 1508 16 studied study VBN cord-015306-us58wwmp 1508 17 . . . cord-015306-us58wwmp 1509 1 To to TO cord-015306-us58wwmp 1509 2 identify identify VB cord-015306-us58wwmp 1509 3 further further RB cord-015306-us58wwmp 1509 4 signaling signal VBG cord-015306-us58wwmp 1509 5 pathways pathway NNS cord-015306-us58wwmp 1509 6 affected affect VBN cord-015306-us58wwmp 1509 7 by by IN cord-015306-us58wwmp 1509 8 EV EV NNP cord-015306-us58wwmp 1509 9 , , , cord-015306-us58wwmp 1509 10 we -PRON- PRP cord-015306-us58wwmp 1509 11 performed perform VBD cord-015306-us58wwmp 1509 12 Affymetrix Affymetrix NNP cord-015306-us58wwmp 1509 13 microarray microarray NN cord-015306-us58wwmp 1509 14 expression expression NN cord-015306-us58wwmp 1509 15 analysis analysis NN cord-015306-us58wwmp 1509 16 followed follow VBN cord-015306-us58wwmp 1509 17 by by IN cord-015306-us58wwmp 1509 18 verification verification NN cord-015306-us58wwmp 1509 19 using use VBG cord-015306-us58wwmp 1509 20 real real JJ cord-015306-us58wwmp 1509 21 - - HYPH cord-015306-us58wwmp 1509 22 time time NN cord-015306-us58wwmp 1509 23 RT RT NNP cord-015306-us58wwmp 1509 24 - - HYPH cord-015306-us58wwmp 1509 25 PCR PCR NNP cord-015306-us58wwmp 1509 26 . . . cord-015306-us58wwmp 1510 1 Results result NNS cord-015306-us58wwmp 1510 2 : : : cord-015306-us58wwmp 1511 1 Biochemical biochemical JJ cord-015306-us58wwmp 1511 2 studies study NNS cord-015306-us58wwmp 1511 3 revealed reveal VBD cord-015306-us58wwmp 1511 4 a a DT cord-015306-us58wwmp 1511 5 substantially substantially RB cord-015306-us58wwmp 1511 6 decreased decrease VBN cord-015306-us58wwmp 1511 7 phosphorylation phosphorylation NN cord-015306-us58wwmp 1511 8 level level NN cord-015306-us58wwmp 1511 9 of of IN cord-015306-us58wwmp 1511 10 both both DT cord-015306-us58wwmp 1511 11 mTOR mtor NN cord-015306-us58wwmp 1511 12 effector effector NN cord-015306-us58wwmp 1511 13 proteins protein NNS cord-015306-us58wwmp 1511 14 mTORC1 mtorc1 CD cord-015306-us58wwmp 1511 15 ( ( -LRB- cord-015306-us58wwmp 1511 16 reduced reduce VBN cord-015306-us58wwmp 1511 17 p p NN cord-015306-us58wwmp 1511 18 - - : cord-015306-us58wwmp 1511 19 Akt Akt NNP cord-015306-us58wwmp 1511 20 ) ) -RRB- cord-015306-us58wwmp 1511 21 and and CC cord-015306-us58wwmp 1511 22 mTORC2 mTORC2 NNPS cord-015306-us58wwmp 1511 23 ( ( -LRB- cord-015306-us58wwmp 1511 24 reduced reduce VBN cord-015306-us58wwmp 1511 25 p p NN cord-015306-us58wwmp 1511 26 - - HYPH cord-015306-us58wwmp 1511 27 p70S6 p70S6 NNP cord-015306-us58wwmp 1511 28 K K NNP cord-015306-us58wwmp 1511 29 ) ) -RRB- cord-015306-us58wwmp 1511 30 by by IN cord-015306-us58wwmp 1511 31 EV EV NNP cord-015306-us58wwmp 1511 32 . . . cord-015306-us58wwmp 1512 1 Objective objective NN cord-015306-us58wwmp 1512 2 : : : cord-015306-us58wwmp 1513 1 Notch notch NN cord-015306-us58wwmp 1513 2 constitutes constitute VBZ cord-015306-us58wwmp 1513 3 an an DT cord-015306-us58wwmp 1513 4 evolutionarily evolutionarily RB cord-015306-us58wwmp 1513 5 conserved conserved JJ cord-015306-us58wwmp 1513 6 intercellular intercellular JJ cord-015306-us58wwmp 1513 7 signaling signal VBG cord-015306-us58wwmp 1513 8 pathway pathway NN cord-015306-us58wwmp 1513 9 that that WDT cord-015306-us58wwmp 1513 10 determines determine VBZ cord-015306-us58wwmp 1513 11 cell cell NN cord-015306-us58wwmp 1513 12 fate fate NN cord-015306-us58wwmp 1513 13 in in IN cord-015306-us58wwmp 1513 14 various various JJ cord-015306-us58wwmp 1513 15 organs organ NNS cord-015306-us58wwmp 1513 16 . . . cord-015306-us58wwmp 1514 1 Activation activation NN cord-015306-us58wwmp 1514 2 of of IN cord-015306-us58wwmp 1514 3 Notch1 Notch1 NNP cord-015306-us58wwmp 1515 1 and and CC cord-015306-us58wwmp 1515 2 Notch2 Notch2 NNP cord-015306-us58wwmp 1515 3 has have VBZ cord-015306-us58wwmp 1515 4 been be VBN cord-015306-us58wwmp 1515 5 implicated implicate VBN cord-015306-us58wwmp 1515 6 in in IN cord-015306-us58wwmp 1515 7 human human JJ cord-015306-us58wwmp 1515 8 glomerular glomerular JJ cord-015306-us58wwmp 1515 9 diseases disease NNS cord-015306-us58wwmp 1515 10 . . . cord-015306-us58wwmp 1516 1 Notch1 Notch1 NNP cord-015306-us58wwmp 1516 2 was be VBD cord-015306-us58wwmp 1516 3 reported report VBN cord-015306-us58wwmp 1516 4 to to TO cord-015306-us58wwmp 1516 5 play play VB cord-015306-us58wwmp 1516 6 a a DT cord-015306-us58wwmp 1516 7 critical critical JJ cord-015306-us58wwmp 1516 8 role role NN cord-015306-us58wwmp 1516 9 in in IN cord-015306-us58wwmp 1516 10 development development NN cord-015306-us58wwmp 1516 11 of of IN cord-015306-us58wwmp 1516 12 glomerular glomerular JJ cord-015306-us58wwmp 1516 13 diseases disease NNS cord-015306-us58wwmp 1516 14 ; ; : cord-015306-us58wwmp 1516 15 however however RB cord-015306-us58wwmp 1516 16 , , , cord-015306-us58wwmp 1516 17 a a DT cord-015306-us58wwmp 1516 18 function function NN cord-015306-us58wwmp 1516 19 of of IN cord-015306-us58wwmp 1516 20 Notch2 Notch2 NNP cord-015306-us58wwmp 1516 21 remains remain VBZ cord-015306-us58wwmp 1516 22 unclear unclear JJ cord-015306-us58wwmp 1516 23 . . . cord-015306-us58wwmp 1517 1 Our -PRON- PRP$ cord-015306-us58wwmp 1517 2 aim aim NN cord-015306-us58wwmp 1517 3 of of IN cord-015306-us58wwmp 1517 4 the the DT cord-015306-us58wwmp 1517 5 study study NN cord-015306-us58wwmp 1517 6 is be VBZ cord-015306-us58wwmp 1517 7 to to TO cord-015306-us58wwmp 1517 8 clarify clarify VB cord-015306-us58wwmp 1517 9 Notch2 Notch2 NNP cord-015306-us58wwmp 1517 10 pathway pathway NN cord-015306-us58wwmp 1517 11 's 's POS cord-015306-us58wwmp 1517 12 contribution contribution NN cord-015306-us58wwmp 1517 13 to to IN cord-015306-us58wwmp 1517 14 developing develop VBG cord-015306-us58wwmp 1517 15 proteinuria proteinuria NN cord-015306-us58wwmp 1517 16 and and CC cord-015306-us58wwmp 1517 17 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 1517 18 . . . cord-015306-us58wwmp 1518 1 Methods method NNS cord-015306-us58wwmp 1519 1 : : : cord-015306-us58wwmp 1519 2 We -PRON- PRP cord-015306-us58wwmp 1519 3 injected inject VBD cord-015306-us58wwmp 1519 4 either either CC cord-015306-us58wwmp 1519 5 Jagged1 Jagged1 NNP cord-015306-us58wwmp 1519 6 antagonistic antagonistic JJ cord-015306-us58wwmp 1519 7 antibody antibody NN cord-015306-us58wwmp 1519 8 ( ( -LRB- cord-015306-us58wwmp 1519 9 mAb mab NN cord-015306-us58wwmp 1519 10 ) ) -RRB- cord-015306-us58wwmp 1519 11 or or CC cord-015306-us58wwmp 1519 12 Notch1 Notch1 NNP cord-015306-us58wwmp 1519 13 agonistic agonistic JJ cord-015306-us58wwmp 1520 1 mAb mAb NNS cord-015306-us58wwmp 1520 2 or or CC cord-015306-us58wwmp 1520 3 Notch2 Notch2 NNP cord-015306-us58wwmp 1520 4 agonistic agonistic JJ cord-015306-us58wwmp 1521 1 mAb mab NN cord-015306-us58wwmp 1521 2 intraperitoneally intraperitoneally RB cord-015306-us58wwmp 1521 3 to to IN cord-015306-us58wwmp 1521 4 mice mouse NNS cord-015306-us58wwmp 1521 5 with with IN cord-015306-us58wwmp 1522 1 adriamycin adriamycin NNP cord-015306-us58wwmp 1522 2 ( ( -LRB- cord-015306-us58wwmp 1522 3 ADR ADR NNP cord-015306-us58wwmp 1522 4 ) ) -RRB- cord-015306-us58wwmp 1522 5 nephropathy nephropathy NN cord-015306-us58wwmp 1522 6 , , , cord-015306-us58wwmp 1522 7 a a DT cord-015306-us58wwmp 1522 8 model model NN cord-015306-us58wwmp 1522 9 of of IN cord-015306-us58wwmp 1522 10 nephrotic nephrotic JJ cord-015306-us58wwmp 1522 11 syndrome syndrome NN cord-015306-us58wwmp 1522 12 and and CC cord-015306-us58wwmp 1522 13 focal focal JJ cord-015306-us58wwmp 1522 14 segmental segmental JJ cord-015306-us58wwmp 1522 15 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 1522 16 , , , cord-015306-us58wwmp 1522 17 and and CC cord-015306-us58wwmp 1522 18 evaluated evaluate VBD cord-015306-us58wwmp 1522 19 the the DT cord-015306-us58wwmp 1522 20 levels level NNS cord-015306-us58wwmp 1522 21 of of IN cord-015306-us58wwmp 1522 22 proteinuria proteinuria NN cord-015306-us58wwmp 1522 23 and and CC cord-015306-us58wwmp 1522 24 the the DT cord-015306-us58wwmp 1522 25 ratios ratio NNS cord-015306-us58wwmp 1522 26 of of IN cord-015306-us58wwmp 1522 27 sclerotic sclerotic JJ cord-015306-us58wwmp 1522 28 glomeruli glomerulus NNS cord-015306-us58wwmp 1522 29 . . . cord-015306-us58wwmp 1523 1 Next next RB cord-015306-us58wwmp 1523 2 , , , cord-015306-us58wwmp 1523 3 we -PRON- PRP cord-015306-us58wwmp 1523 4 treated treat VBD cord-015306-us58wwmp 1523 5 cultured cultured JJ cord-015306-us58wwmp 1523 6 podocytes podocyte NNS cord-015306-us58wwmp 1523 7 with with IN cord-015306-us58wwmp 1523 8 ADR ADR NNP cord-015306-us58wwmp 1523 9 in in IN cord-015306-us58wwmp 1523 10 the the DT cord-015306-us58wwmp 1523 11 presence presence NN cord-015306-us58wwmp 1523 12 or or CC cord-015306-us58wwmp 1523 13 absence absence NN cord-015306-us58wwmp 1523 14 of of IN cord-015306-us58wwmp 1523 15 Notch2 Notch2 NNP cord-015306-us58wwmp 1524 1 agonistic agonistic JJ cord-015306-us58wwmp 1524 2 mAb mAb NNS cord-015306-us58wwmp 1524 3 , , , cord-015306-us58wwmp 1525 1 and and CC cord-015306-us58wwmp 1525 2 we -PRON- PRP cord-015306-us58wwmp 1525 3 assessed assess VBD cord-015306-us58wwmp 1525 4 the the DT cord-015306-us58wwmp 1525 5 effect effect NN cord-015306-us58wwmp 1525 6 on on IN cord-015306-us58wwmp 1525 7 cell cell NN cord-015306-us58wwmp 1525 8 survival survival NN cord-015306-us58wwmp 1525 9 and and CC cord-015306-us58wwmp 1525 10 examined examine VBD cord-015306-us58wwmp 1525 11 the the DT cord-015306-us58wwmp 1525 12 pathways pathway NNS cord-015306-us58wwmp 1525 13 involved involve VBN cord-015306-us58wwmp 1525 14 . . . cord-015306-us58wwmp 1526 1 Then then RB cord-015306-us58wwmp 1526 2 , , , cord-015306-us58wwmp 1526 3 we -PRON- PRP cord-015306-us58wwmp 1526 4 evaluated evaluate VBD cord-015306-us58wwmp 1526 5 a a DT cord-015306-us58wwmp 1526 6 correlation correlation NN cord-015306-us58wwmp 1526 7 between between IN cord-015306-us58wwmp 1526 8 Notch2 Notch2 NNP cord-015306-us58wwmp 1526 9 activation activation NN cord-015306-us58wwmp 1526 10 and and CC cord-015306-us58wwmp 1526 11 podocyte podocyte JJ cord-015306-us58wwmp 1526 12 loss loss NN cord-015306-us58wwmp 1526 13 in in IN cord-015306-us58wwmp 1526 14 human human JJ cord-015306-us58wwmp 1526 15 kidney kidney NN cord-015306-us58wwmp 1526 16 specimen specimen NN cord-015306-us58wwmp 1526 17 of of IN cord-015306-us58wwmp 1526 18 nephrosis nephrosis NN cord-015306-us58wwmp 1526 19 , , , cord-015306-us58wwmp 1526 20 minimal minimal JJ cord-015306-us58wwmp 1526 21 change change NN cord-015306-us58wwmp 1526 22 disease disease NN cord-015306-us58wwmp 1526 23 ( ( -LRB- cord-015306-us58wwmp 1526 24 MCNS MCNS NNP cord-015306-us58wwmp 1526 25 ) ) -RRB- cord-015306-us58wwmp 1526 26 and and CC cord-015306-us58wwmp 1526 27 focal focal JJ cord-015306-us58wwmp 1526 28 segmental segmental JJ cord-015306-us58wwmp 1526 29 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 1526 30 ( ( -LRB- cord-015306-us58wwmp 1526 31 FSGS FSGS NNP cord-015306-us58wwmp 1526 32 ) ) -RRB- cord-015306-us58wwmp 1526 33 . . . cord-015306-us58wwmp 1527 1 Results result NNS cord-015306-us58wwmp 1527 2 : : : cord-015306-us58wwmp 1528 1 Administration administration NN cord-015306-us58wwmp 1528 2 of of IN cord-015306-us58wwmp 1528 3 Notch2 Notch2 NNP cord-015306-us58wwmp 1529 1 agonistic agonistic JJ cord-015306-us58wwmp 1529 2 mAb mAb HYPH cord-015306-us58wwmp 1529 3 ameliorated ameliorate VBN cord-015306-us58wwmp 1529 4 nephrosis nephrosis NN cord-015306-us58wwmp 1529 5 and and CC cord-015306-us58wwmp 1529 6 glomerulosclerosis glomerulosclerosis NNP cord-015306-us58wwmp 1529 7 in in IN cord-015306-us58wwmp 1529 8 mice mouse NNS cord-015306-us58wwmp 1529 9 with with IN cord-015306-us58wwmp 1529 10 ADR ADR NNP cord-015306-us58wwmp 1529 11 nephropathy nephropathy NN cord-015306-us58wwmp 1529 12 , , , cord-015306-us58wwmp 1529 13 even even RB cord-015306-us58wwmp 1529 14 when when WRB cord-015306-us58wwmp 1529 15 Notch2 Notch2 NNP cord-015306-us58wwmp 1529 16 agonistic agonistic JJ cord-015306-us58wwmp 1529 17 mAb mAb NNS cord-015306-us58wwmp 1529 18 was be VBD cord-015306-us58wwmp 1529 19 administered administer VBN cord-015306-us58wwmp 1529 20 therapeutically therapeutically RB cord-015306-us58wwmp 1529 21 after after IN cord-015306-us58wwmp 1529 22 the the DT cord-015306-us58wwmp 1529 23 onset onset NN cord-015306-us58wwmp 1529 24 of of IN cord-015306-us58wwmp 1529 25 nephrosis nephrosis NN cord-015306-us58wwmp 1529 26 . . . cord-015306-us58wwmp 1530 1 In in IN cord-015306-us58wwmp 1530 2 vitro vitro FW cord-015306-us58wwmp 1530 3 , , , cord-015306-us58wwmp 1530 4 Notch2 Notch2 NNP cord-015306-us58wwmp 1530 5 agonistic agonistic JJ cord-015306-us58wwmp 1530 6 mAb mAb HYPH cord-015306-us58wwmp 1530 7 protected protect VBN cord-015306-us58wwmp 1530 8 ADR adr NN cord-015306-us58wwmp 1530 9 - - HYPH cord-015306-us58wwmp 1530 10 damaged damage VBN cord-015306-us58wwmp 1530 11 podocytes podocyte NNS cord-015306-us58wwmp 1530 12 from from IN cord-015306-us58wwmp 1530 13 apoptotic apoptotic JJ cord-015306-us58wwmp 1530 14 cell cell NN cord-015306-us58wwmp 1530 15 death death NN cord-015306-us58wwmp 1530 16 . . . cord-015306-us58wwmp 1531 1 The the DT cord-015306-us58wwmp 1531 2 specific specific JJ cord-015306-us58wwmp 1531 3 knockdown knockdown NN cord-015306-us58wwmp 1531 4 of of IN cord-015306-us58wwmp 1531 5 Notch2 Notch2 NNP cord-015306-us58wwmp 1531 6 led lead VBD cord-015306-us58wwmp 1531 7 to to IN cord-015306-us58wwmp 1531 8 increased increase VBN cord-015306-us58wwmp 1531 9 apoptosis apoptosis NN cord-015306-us58wwmp 1531 10 in in IN cord-015306-us58wwmp 1531 11 damaged damage VBN cord-015306-us58wwmp 1531 12 podocytes podocyte NNS cord-015306-us58wwmp 1531 13 . . . cord-015306-us58wwmp 1532 1 Notch2 Notch2 NNP cord-015306-us58wwmp 1532 2 rescued rescue VBD cord-015306-us58wwmp 1532 3 damaged damage VBN cord-015306-us58wwmp 1532 4 podocytes podocyte NNS cord-015306-us58wwmp 1532 5 from from IN cord-015306-us58wwmp 1532 6 apoptosis apoptosis NN cord-015306-us58wwmp 1532 7 through through IN cord-015306-us58wwmp 1532 8 Akt Akt NNP cord-015306-us58wwmp 1532 9 pathway pathway NN cord-015306-us58wwmp 1532 10 . . . cord-015306-us58wwmp 1533 1 Human human JJ cord-015306-us58wwmp 1533 2 kidney kidney NN cord-015306-us58wwmp 1533 3 specimens specimen NNS cord-015306-us58wwmp 1533 4 of of IN cord-015306-us58wwmp 1533 5 nephrosis nephrosis NN cord-015306-us58wwmp 1533 6 showed show VBD cord-015306-us58wwmp 1533 7 a a DT cord-015306-us58wwmp 1533 8 positive positive JJ cord-015306-us58wwmp 1533 9 linear linear JJ cord-015306-us58wwmp 1533 10 correlation correlation NN cord-015306-us58wwmp 1533 11 between between IN cord-015306-us58wwmp 1533 12 the the DT cord-015306-us58wwmp 1533 13 number number NN cord-015306-us58wwmp 1533 14 of of IN cord-015306-us58wwmp 1533 15 podocytes podocyte NNS cord-015306-us58wwmp 1533 16 expressing express VBG cord-015306-us58wwmp 1533 17 activated activate VBN cord-015306-us58wwmp 1533 18 Notch2 Notch2 NNP cord-015306-us58wwmp 1534 1 and and CC cord-015306-us58wwmp 1534 2 the the DT cord-015306-us58wwmp 1534 3 number number NN cord-015306-us58wwmp 1534 4 of of IN cord-015306-us58wwmp 1534 5 residual residual JJ cord-015306-us58wwmp 1534 6 podocytes podocyte NNS cord-015306-us58wwmp 1534 7 . . . cord-015306-us58wwmp 1535 1 The the DT cord-015306-us58wwmp 1535 2 glomeruli glomerulus NNS cord-015306-us58wwmp 1535 3 with with IN cord-015306-us58wwmp 1535 4 MCNS MCNS NNP cord-015306-us58wwmp 1535 5 showed show VBD cord-015306-us58wwmp 1535 6 more more RBR cord-015306-us58wwmp 1535 7 activated activate VBN cord-015306-us58wwmp 1535 8 Notch2 Notch2 NNP cord-015306-us58wwmp 1535 9 and and CC cord-015306-us58wwmp 1535 10 more more JJR cord-015306-us58wwmp 1535 11 podocytes podocyte NNS cord-015306-us58wwmp 1535 12 , , , cord-015306-us58wwmp 1535 13 Conclusions conclusion NNS cord-015306-us58wwmp 1535 14 : : : cord-015306-us58wwmp 1535 15 whereas whereas IN cord-015306-us58wwmp 1535 16 those those DT cord-015306-us58wwmp 1535 17 with with IN cord-015306-us58wwmp 1535 18 FSGS FSGS NNP cord-015306-us58wwmp 1535 19 showed show VBD cord-015306-us58wwmp 1535 20 less less RBR cord-015306-us58wwmp 1535 21 activated activate VBN cord-015306-us58wwmp 1535 22 Notch2 Notch2 NNP cord-015306-us58wwmp 1535 23 and and CC cord-015306-us58wwmp 1535 24 less less JJR cord-015306-us58wwmp 1535 25 podocytes podocyte NNS cord-015306-us58wwmp 1535 26 . . . cord-015306-us58wwmp 1536 1 Notch2 Notch2 NNP cord-015306-us58wwmp 1536 2 pathway pathway NN cord-015306-us58wwmp 1536 3 has have VBZ cord-015306-us58wwmp 1536 4 a a DT cord-015306-us58wwmp 1536 5 pivotal pivotal JJ cord-015306-us58wwmp 1536 6 role role NN cord-015306-us58wwmp 1536 7 in in IN cord-015306-us58wwmp 1536 8 preventing prevent VBG cord-015306-us58wwmp 1536 9 apoptosis apoptosis NN cord-015306-us58wwmp 1536 10 of of IN cord-015306-us58wwmp 1536 11 damaged damage VBN cord-015306-us58wwmp 1536 12 podocytes podocyte NNS cord-015306-us58wwmp 1536 13 . . . cord-015306-us58wwmp 1537 1 Specific specific JJ cord-015306-us58wwmp 1537 2 activation activation NN cord-015306-us58wwmp 1537 3 of of IN cord-015306-us58wwmp 1537 4 Notch2 Notch2 NNP cord-015306-us58wwmp 1537 5 may may MD cord-015306-us58wwmp 1537 6 represent represent VB cord-015306-us58wwmp 1537 7 a a DT cord-015306-us58wwmp 1537 8 novel novel JJ cord-015306-us58wwmp 1537 9 clinical clinical JJ cord-015306-us58wwmp 1537 10 strategy strategy NN cord-015306-us58wwmp 1537 11 for for IN cord-015306-us58wwmp 1537 12 the the DT cord-015306-us58wwmp 1537 13 amelioration amelioration NN cord-015306-us58wwmp 1537 14 of of IN cord-015306-us58wwmp 1537 15 nephrosis nephrosis NN cord-015306-us58wwmp 1537 16 and and CC cord-015306-us58wwmp 1537 17 glomerulosclerosis glomerulosclerosis NNP cord-015306-us58wwmp 1537 18 . . . cord-015306-us58wwmp 1538 1 Abstract abstract JJ cord-015306-us58wwmp 1538 2 # # NN cord-015306-us58wwmp 1539 1 P p NN cord-015306-us58wwmp 1539 2 - - HYPH cord-015306-us58wwmp 1539 3 SAT191 SAT191 NNP cord-015306-us58wwmp 1539 4 Proliferation Proliferation NNP cord-015306-us58wwmp 1539 5 and and CC cord-015306-us58wwmp 1539 6 apoptosis apoptosis NN cord-015306-us58wwmp 1539 7 of of IN cord-015306-us58wwmp 1539 8 tubular tubular JJ cord-015306-us58wwmp 1539 9 cells cell NNS cord-015306-us58wwmp 1539 10 in in IN cord-015306-us58wwmp 1539 11 initial initial JJ cord-015306-us58wwmp 1539 12 and and CC cord-015306-us58wwmp 1539 13 advanced advanced JJ cord-015306-us58wwmp 1539 14 stages stage NNS cord-015306-us58wwmp 1539 15 of of IN cord-015306-us58wwmp 1539 16 focal focal JJ cord-015306-us58wwmp 1539 17 segmental segmental JJ cord-015306-us58wwmp 1539 18 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 1539 19 ( ( -LRB- cord-015306-us58wwmp 1539 20 FSGS FSGS NNP cord-015306-us58wwmp 1539 21 ) ) -RRB- cord-015306-us58wwmp 1539 22 Objective objective NN cord-015306-us58wwmp 1539 23 : : : cord-015306-us58wwmp 1540 1 To to TO cord-015306-us58wwmp 1540 2 analyze analyze VB cord-015306-us58wwmp 1540 3 processes process NNS cord-015306-us58wwmp 1540 4 of of IN cord-015306-us58wwmp 1540 5 proliferation proliferation NN cord-015306-us58wwmp 1540 6 , , , cord-015306-us58wwmp 1540 7 apoptosis apoptosis NN cord-015306-us58wwmp 1540 8 and and CC cord-015306-us58wwmp 1540 9 ciliogenesis ciliogenesis NN cord-015306-us58wwmp 1540 10 in in IN cord-015306-us58wwmp 1540 11 proximal proximal JJ cord-015306-us58wwmp 1540 12 tubular tubular JJ cord-015306-us58wwmp 1540 13 cells cell NNS cord-015306-us58wwmp 1540 14 during during IN cord-015306-us58wwmp 1540 15 initial initial JJ cord-015306-us58wwmp 1540 16 and and CC cord-015306-us58wwmp 1540 17 advanced advanced JJ cord-015306-us58wwmp 1540 18 stages stage NNS cord-015306-us58wwmp 1540 19 of of IN cord-015306-us58wwmp 1540 20 FSGS FSGS NNP cord-015306-us58wwmp 1540 21 associated associate VBN cord-015306-us58wwmp 1540 22 with with IN cord-015306-us58wwmp 1540 23 cystogenesis cystogenesis NN cord-015306-us58wwmp 1540 24 . . . cord-015306-us58wwmp 1541 1 Methods method NNS cord-015306-us58wwmp 1541 2 : : : cord-015306-us58wwmp 1541 3 Normal normal JJ cord-015306-us58wwmp 1541 4 kidney kidney NN cord-015306-us58wwmp 1541 5 tissues tissue NNS cord-015306-us58wwmp 1541 6 and and CC cord-015306-us58wwmp 1541 7 tissues tissue NNS cord-015306-us58wwmp 1541 8 of of IN cord-015306-us58wwmp 1541 9 FSGS FSGS NNP cord-015306-us58wwmp 1541 10 kidneys kidney NNS cord-015306-us58wwmp 1541 11 were be VBD cord-015306-us58wwmp 1541 12 immunohistochemically immunohistochemically RB cord-015306-us58wwmp 1541 13 analyzed analyze VBN cord-015306-us58wwmp 1541 14 using use VBG cord-015306-us58wwmp 1541 15 Ki-67 Ki-67 NNP cord-015306-us58wwmp 1541 16 proliferation proliferation NN cord-015306-us58wwmp 1541 17 marker marker NN cord-015306-us58wwmp 1541 18 and and CC cord-015306-us58wwmp 1541 19 caspase-3 caspase-3 NNP cord-015306-us58wwmp 1541 20 apoptotic apoptotic JJ cord-015306-us58wwmp 1541 21 marker marker NN cord-015306-us58wwmp 1541 22 . . . cord-015306-us58wwmp 1542 1 Diameters diameter NNS cord-015306-us58wwmp 1542 2 of of IN cord-015306-us58wwmp 1542 3 dilated dilated JJ cord-015306-us58wwmp 1542 4 and and CC cord-015306-us58wwmp 1542 5 cystic cystic JJ cord-015306-us58wwmp 1542 6 proximal proximal JJ cord-015306-us58wwmp 1542 7 tubules tubule NNS cord-015306-us58wwmp 1542 8 were be VBD cord-015306-us58wwmp 1542 9 measured measure VBN cord-015306-us58wwmp 1542 10 and and CC cord-015306-us58wwmp 1542 11 correlated correlate VBN cord-015306-us58wwmp 1542 12 with with IN cord-015306-us58wwmp 1542 13 proliferation proliferation NN cord-015306-us58wwmp 1542 14 index index NN cord-015306-us58wwmp 1542 15 of of IN cord-015306-us58wwmp 1542 16 tubular tubular JJ cord-015306-us58wwmp 1542 17 cells cell NNS cord-015306-us58wwmp 1542 18 . . . cord-015306-us58wwmp 1543 1 Data datum NNS cord-015306-us58wwmp 1543 2 were be VBD cord-015306-us58wwmp 1543 3 analysed analyse VBN cord-015306-us58wwmp 1543 4 by by IN cord-015306-us58wwmp 1543 5 the the DT cord-015306-us58wwmp 1543 6 Kruskal Kruskal NNP cord-015306-us58wwmp 1543 7 - - HYPH cord-015306-us58wwmp 1543 8 Wallis Wallis NNP cord-015306-us58wwmp 1543 9 and and CC cord-015306-us58wwmp 1543 10 Dunn Dunn NNP cord-015306-us58wwmp 1543 11 's 's POS cord-015306-us58wwmp 1543 12 post post FW cord-015306-us58wwmp 1543 13 hoc hoc FW cord-015306-us58wwmp 1543 14 test test NN cord-015306-us58wwmp 1543 15 and and CC cord-015306-us58wwmp 1543 16 expressed express VBD cord-015306-us58wwmp 1543 17 as as IN cord-015306-us58wwmp 1543 18 mean+/−SD mean+/−SD NNS cord-015306-us58wwmp 1543 19 . . . cord-015306-us58wwmp 1544 1 Significance significance NN cord-015306-us58wwmp 1544 2 was be VBD cord-015306-us58wwmp 1544 3 accepted accept VBN cord-015306-us58wwmp 1544 4 at at IN cord-015306-us58wwmp 1544 5 p<0.05 p<0.05 CD cord-015306-us58wwmp 1544 6 . . . cord-015306-us58wwmp 1545 1 Results result NNS cord-015306-us58wwmp 1545 2 : : : cord-015306-us58wwmp 1546 1 Normal normal JJ cord-015306-us58wwmp 1546 2 kidney kidney NN cord-015306-us58wwmp 1546 3 tissue tissue NN cord-015306-us58wwmp 1546 4 showed show VBD cord-015306-us58wwmp 1546 5 absence absence NN cord-015306-us58wwmp 1546 6 of of IN cord-015306-us58wwmp 1546 7 proliferation proliferation NN cord-015306-us58wwmp 1546 8 in in IN cord-015306-us58wwmp 1546 9 proximal proximal JJ cord-015306-us58wwmp 1546 10 tubules tubule NNS cord-015306-us58wwmp 1546 11 . . . cord-015306-us58wwmp 1547 1 Initial initial JJ cord-015306-us58wwmp 1547 2 stages stage NNS cord-015306-us58wwmp 1547 3 of of IN cord-015306-us58wwmp 1547 4 FSGS FSGS NNP cord-015306-us58wwmp 1547 5 were be VBD cord-015306-us58wwmp 1547 6 characterized characterize VBN cord-015306-us58wwmp 1547 7 by by IN cord-015306-us58wwmp 1547 8 intermingling intermingle VBG cord-015306-us58wwmp 1547 9 areas area NNS cord-015306-us58wwmp 1547 10 of of IN cord-015306-us58wwmp 1547 11 healthy healthy JJ cord-015306-us58wwmp 1547 12 non non JJ cord-015306-us58wwmp 1547 13 - - JJ cord-015306-us58wwmp 1547 14 proliferating proliferating JJ cord-015306-us58wwmp 1547 15 proximal proximal JJ cord-015306-us58wwmp 1547 16 tubules tubule NNS cord-015306-us58wwmp 1547 17 , , , cord-015306-us58wwmp 1547 18 and and CC cord-015306-us58wwmp 1547 19 pathologically pathologically RB cord-015306-us58wwmp 1547 20 changes change NNS cord-015306-us58wwmp 1547 21 , , , cord-015306-us58wwmp 1547 22 mildly mildly RB cord-015306-us58wwmp 1547 23 dilated dilated JJ cord-015306-us58wwmp 1547 24 ( ( -LRB- cord-015306-us58wwmp 1547 25 15um 15um JJ cord-015306-us58wwmp 1547 26 diameter diameter NN cord-015306-us58wwmp 1547 27 ) ) -RRB- cord-015306-us58wwmp 1547 28 proximal proximal JJ cord-015306-us58wwmp 1547 29 tubules tubule NNS cord-015306-us58wwmp 1547 30 showing show VBG cord-015306-us58wwmp 1547 31 proliferation proliferation NN cord-015306-us58wwmp 1547 32 index index NN cord-015306-us58wwmp 1547 33 of of IN cord-015306-us58wwmp 1547 34 15.92 15.92 CD cord-015306-us58wwmp 1547 35 % % NN cord-015306-us58wwmp 1547 36 . . . cord-015306-us58wwmp 1548 1 Advances advance NNS cord-015306-us58wwmp 1548 2 stages stage NNS cord-015306-us58wwmp 1548 3 of of IN cord-015306-us58wwmp 1548 4 FSGS FSGS NNP cord-015306-us58wwmp 1548 5 displayed display VBD cord-015306-us58wwmp 1548 6 different different JJ cord-015306-us58wwmp 1548 7 stages stage NNS cord-015306-us58wwmp 1548 8 of of IN cord-015306-us58wwmp 1548 9 cystogenesis cystogenesis NN cord-015306-us58wwmp 1548 10 : : : cord-015306-us58wwmp 1548 11 while while IN cord-015306-us58wwmp 1548 12 mildly mildly RB cord-015306-us58wwmp 1548 13 dilated dilated JJ cord-015306-us58wwmp 1548 14 tubules tubule NNS cord-015306-us58wwmp 1548 15 ( ( -LRB- cord-015306-us58wwmp 1548 16 diameter diameter NN cord-015306-us58wwmp 1548 17 12+/−1.4um 12+/−1.4um CD cord-015306-us58wwmp 1548 18 ) ) -RRB- cord-015306-us58wwmp 1548 19 contained contain VBD cord-015306-us58wwmp 1548 20 36,18 36,18 CD cord-015306-us58wwmp 1548 21 % % NN cord-015306-us58wwmp 1548 22 of of IN cord-015306-us58wwmp 1548 23 proliferating proliferate VBG cord-015306-us58wwmp 1548 24 cells cell NNS cord-015306-us58wwmp 1548 25 , , , cord-015306-us58wwmp 1548 26 their -PRON- PRP$ cord-015306-us58wwmp 1548 27 number number NN cord-015306-us58wwmp 1548 28 increased increase VBD cord-015306-us58wwmp 1548 29 to to IN cord-015306-us58wwmp 1548 30 45,23 45,23 CD cord-015306-us58wwmp 1548 31 % % NN cord-015306-us58wwmp 1548 32 in in IN cord-015306-us58wwmp 1548 33 cysts cyst NNS cord-015306-us58wwmp 1548 34 with with IN cord-015306-us58wwmp 1548 35 diameters diameter NNS cord-015306-us58wwmp 1548 36 from from IN cord-015306-us58wwmp 1548 37 21+/−1.8um 21+/−1.8um CD cord-015306-us58wwmp 1548 38 to to IN cord-015306-us58wwmp 1548 39 54+/−1.1um 54+/−1.1um CD cord-015306-us58wwmp 1548 40 , , , cord-015306-us58wwmp 1548 41 and and CC cord-015306-us58wwmp 1548 42 then then RB cord-015306-us58wwmp 1548 43 decreased decrease VBD cord-015306-us58wwmp 1548 44 to to IN cord-015306-us58wwmp 1548 45 13,76 13,76 CD cord-015306-us58wwmp 1548 46 % % NN cord-015306-us58wwmp 1548 47 in in IN cord-015306-us58wwmp 1548 48 cysts cyst NNS cord-015306-us58wwmp 1548 49 with with IN cord-015306-us58wwmp 1548 50 diameter diameter NN cord-015306-us58wwmp 1548 51 73+/−2.1um 73+/−2.1um CD cord-015306-us58wwmp 1548 52 . . . cord-015306-us58wwmp 1549 1 While while IN cord-015306-us58wwmp 1549 2 in in IN cord-015306-us58wwmp 1549 3 the the DT cord-015306-us58wwmp 1549 4 largest large JJS cord-015306-us58wwmp 1549 5 cysts cyst NNS cord-015306-us58wwmp 1549 6 proliferation proliferation NN cord-015306-us58wwmp 1549 7 index index NN cord-015306-us58wwmp 1549 8 was be VBD cord-015306-us58wwmp 1549 9 lowest low JJS cord-015306-us58wwmp 1549 10 and and CC cord-015306-us58wwmp 1549 11 the the DT cord-015306-us58wwmp 1549 12 primary primary JJ cord-015306-us58wwmp 1549 13 cilia cilium NNS cord-015306-us58wwmp 1549 14 short short RB cord-015306-us58wwmp 1549 15 and and CC cord-015306-us58wwmp 1549 16 distorted distorted JJ cord-015306-us58wwmp 1549 17 , , , cord-015306-us58wwmp 1549 18 in in IN cord-015306-us58wwmp 1549 19 distal distal JJ cord-015306-us58wwmp 1549 20 tubules tubule NNS cord-015306-us58wwmp 1549 21 and and CC cord-015306-us58wwmp 1549 22 collecting collect VBG cord-015306-us58wwmp 1549 23 ducts duct NNS cord-015306-us58wwmp 1549 24 , , , cord-015306-us58wwmp 1549 25 primary primary JJ cord-015306-us58wwmp 1549 26 cilia cilium NNS cord-015306-us58wwmp 1549 27 were be VBD cord-015306-us58wwmp 1549 28 extremely extremely RB cord-015306-us58wwmp 1549 29 long long JJ cord-015306-us58wwmp 1549 30 and and CC cord-015306-us58wwmp 1549 31 branching branch VBG cord-015306-us58wwmp 1549 32 . . . cord-015306-us58wwmp 1550 1 Apoptotic Apoptotic NNP cord-015306-us58wwmp 1550 2 caspase-3 caspase-3 NNP cord-015306-us58wwmp 1550 3 positive positive JJ cord-015306-us58wwmp 1550 4 cells cell NNS cord-015306-us58wwmp 1550 5 were be VBD cord-015306-us58wwmp 1550 6 observed observe VBN cord-015306-us58wwmp 1550 7 within within IN cord-015306-us58wwmp 1550 8 the the DT cord-015306-us58wwmp 1550 9 tubular tubular JJ cord-015306-us58wwmp 1550 10 and and CC cord-015306-us58wwmp 1550 11 interstitial interstitial JJ cord-015306-us58wwmp 1550 12 cells cell NNS cord-015306-us58wwmp 1550 13 . . . cord-015306-us58wwmp 1551 1 Conclusion conclusion NN cord-015306-us58wwmp 1551 2 : : : cord-015306-us58wwmp 1552 1 Deterioration deterioration NN cord-015306-us58wwmp 1552 2 of of IN cord-015306-us58wwmp 1552 3 proliferation proliferation NN cord-015306-us58wwmp 1552 4 and and CC cord-015306-us58wwmp 1552 5 apoptosis apoptosis NN cord-015306-us58wwmp 1552 6 , , , cord-015306-us58wwmp 1552 7 and and CC cord-015306-us58wwmp 1552 8 primary primary JJ cord-015306-us58wwmp 1552 9 cilia cilia NN cord-015306-us58wwmp 1552 10 formation formation NN cord-015306-us58wwmp 1552 11 characterizes characterize VBZ cord-015306-us58wwmp 1552 12 cystogenesis cystogenesis NN cord-015306-us58wwmp 1552 13 in in IN cord-015306-us58wwmp 1552 14 FSGS FSGS NNP cord-015306-us58wwmp 1552 15 kidneys kidney NNS cord-015306-us58wwmp 1552 16 . . . cord-015306-us58wwmp 1553 1 We -PRON- PRP cord-015306-us58wwmp 1553 2 suggest suggest VBP cord-015306-us58wwmp 1553 3 that that IN cord-015306-us58wwmp 1553 4 changes change NNS cord-015306-us58wwmp 1553 5 in in IN cord-015306-us58wwmp 1553 6 primary primary JJ cord-015306-us58wwmp 1553 7 cilia cilium NNS cord-015306-us58wwmp 1553 8 length length NN cord-015306-us58wwmp 1553 9 might may MD cord-015306-us58wwmp 1553 10 cause cause VB cord-015306-us58wwmp 1553 11 alterations alteration NNS cord-015306-us58wwmp 1553 12 in in IN cord-015306-us58wwmp 1553 13 transfer transfer NN cord-015306-us58wwmp 1553 14 of of IN cord-015306-us58wwmp 1553 15 signaling signal VBG cord-015306-us58wwmp 1553 16 pathways pathway NNS cord-015306-us58wwmp 1553 17 which which WDT cord-015306-us58wwmp 1553 18 control control VBP cord-015306-us58wwmp 1553 19 proliferation proliferation NN cord-015306-us58wwmp 1553 20 , , , cord-015306-us58wwmp 1553 21 differentiation differentiation NN cord-015306-us58wwmp 1553 22 and and CC cord-015306-us58wwmp 1553 23 apoptosis apoptosis NN cord-015306-us58wwmp 1553 24 of of IN cord-015306-us58wwmp 1553 25 proximal proximal JJ cord-015306-us58wwmp 1553 26 tubules tubule NNS cord-015306-us58wwmp 1553 27 cells cell NNS cord-015306-us58wwmp 1553 28 . . . cord-015306-us58wwmp 1554 1 Advanced advanced JJ cord-015306-us58wwmp 1554 2 stages stage NNS cord-015306-us58wwmp 1554 3 of of IN cord-015306-us58wwmp 1554 4 FSGS FSGS NNP cord-015306-us58wwmp 1554 5 are be VBP cord-015306-us58wwmp 1554 6 associated associate VBN cord-015306-us58wwmp 1554 7 with with IN cord-015306-us58wwmp 1554 8 cyst cyst NN cord-015306-us58wwmp 1554 9 formation formation NN cord-015306-us58wwmp 1554 10 and and CC cord-015306-us58wwmp 1554 11 increased increase VBD cord-015306-us58wwmp 1554 12 proteinuria proteinuria NN cord-015306-us58wwmp 1554 13 leading lead VBG cord-015306-us58wwmp 1554 14 to to IN cord-015306-us58wwmp 1554 15 nephrotic nephrotic JJ cord-015306-us58wwmp 1554 16 syndorme syndorme NNP cord-015306-us58wwmp 1554 17 Objective objective NN cord-015306-us58wwmp 1554 18 : : : cord-015306-us58wwmp 1555 1 To to TO cord-015306-us58wwmp 1555 2 investigate investigate VB cord-015306-us58wwmp 1555 3 effect effect NN cord-015306-us58wwmp 1555 4 of of IN cord-015306-us58wwmp 1555 5 prednisone prednisone NN cord-015306-us58wwmp 1555 6 on on IN cord-015306-us58wwmp 1555 7 the the DT cord-015306-us58wwmp 1555 8 expression expression NN cord-015306-us58wwmp 1555 9 of of IN cord-015306-us58wwmp 1555 10 Ezrin Ezrin NNP cord-015306-us58wwmp 1555 11 and and CC cord-015306-us58wwmp 1555 12 NEPH1 NEPH1 NNS cord-015306-us58wwmp 1555 13 in in IN cord-015306-us58wwmp 1555 14 rats rat NNS cord-015306-us58wwmp 1555 15 with with IN cord-015306-us58wwmp 1555 16 adriamycin adriamycin NN cord-015306-us58wwmp 1555 17 - - HYPH cord-015306-us58wwmp 1555 18 induced induce VBN cord-015306-us58wwmp 1555 19 nephrosis nephrosis NN cord-015306-us58wwmp 1555 20 . . . cord-015306-us58wwmp 1556 1 Methods method NNS cord-015306-us58wwmp 1556 2 : : : cord-015306-us58wwmp 1556 3 ADR adr NN cord-015306-us58wwmp 1556 4 model model NN cord-015306-us58wwmp 1556 5 was be VBD cord-015306-us58wwmp 1556 6 induced induce VBN cord-015306-us58wwmp 1556 7 by by IN cord-015306-us58wwmp 1556 8 a a DT cord-015306-us58wwmp 1556 9 tail tail NN cord-015306-us58wwmp 1556 10 intravenous intravenous JJ cord-015306-us58wwmp 1556 11 injection injection NN cord-015306-us58wwmp 1556 12 of of IN cord-015306-us58wwmp 1556 13 ADR.The ADR.The NNP cord-015306-us58wwmp 1556 14 rats rat NNS cord-015306-us58wwmp 1556 15 were be VBD cord-015306-us58wwmp 1556 16 divided divide VBN cord-015306-us58wwmp 1556 17 into into IN cord-015306-us58wwmp 1556 18 three three CD cord-015306-us58wwmp 1556 19 groups group NNS cord-015306-us58wwmp 1556 20 , , , cord-015306-us58wwmp 1556 21 which which WDT cord-015306-us58wwmp 1556 22 were be VBD cord-015306-us58wwmp 1556 23 control control NN cord-015306-us58wwmp 1556 24 group group NN cord-015306-us58wwmp 1556 25 , , , cord-015306-us58wwmp 1556 26 model model NN cord-015306-us58wwmp 1556 27 group group NN cord-015306-us58wwmp 1556 28 and and CC cord-015306-us58wwmp 1556 29 prednisone prednisone NNP cord-015306-us58wwmp 1556 30 group group NNP cord-015306-us58wwmp 1556 31 . . . cord-015306-us58wwmp 1557 1 Serum serum NN cord-015306-us58wwmp 1557 2 index index NN cord-015306-us58wwmp 1557 3 and and CC cord-015306-us58wwmp 1557 4 24h 24h NNP cord-015306-us58wwmp 1557 5 urinary urinary JJ cord-015306-us58wwmp 1557 6 protein protein NN cord-015306-us58wwmp 1557 7 were be VBD cord-015306-us58wwmp 1557 8 measured measure VBN cord-015306-us58wwmp 1557 9 at at IN cord-015306-us58wwmp 1557 10 4 4 CD cord-015306-us58wwmp 1557 11 and and CC cord-015306-us58wwmp 1557 12 8 8 CD cord-015306-us58wwmp 1557 13 weeks week NNS cord-015306-us58wwmp 1557 14 . . . cord-015306-us58wwmp 1558 1 Observe observe VB cord-015306-us58wwmp 1558 2 pathologic pathologic JJ cord-015306-us58wwmp 1558 3 changes change NNS cord-015306-us58wwmp 1558 4 of of IN cord-015306-us58wwmp 1558 5 renal renal JJ cord-015306-us58wwmp 1558 6 tissues tissue NNS cord-015306-us58wwmp 1558 7 at at IN cord-015306-us58wwmp 1558 8 8 8 CD cord-015306-us58wwmp 1558 9 weeks week NNS cord-015306-us58wwmp 1558 10 . . . cord-015306-us58wwmp 1559 1 The the DT cord-015306-us58wwmp 1559 2 expression expression NN cord-015306-us58wwmp 1559 3 of of IN cord-015306-us58wwmp 1559 4 Ezrin Ezrin NNP cord-015306-us58wwmp 1559 5 and and CC cord-015306-us58wwmp 1559 6 NEPH1 NEPH1 NNS cord-015306-us58wwmp 1559 7 in in IN cord-015306-us58wwmp 1559 8 glomerulus glomerulus NN cord-015306-us58wwmp 1559 9 was be VBD cord-015306-us58wwmp 1559 10 evaluated evaluate VBN cord-015306-us58wwmp 1559 11 by by IN cord-015306-us58wwmp 1559 12 immunohistochemistry immunohistochemistry NN cord-015306-us58wwmp 1559 13 respectively respectively RB cord-015306-us58wwmp 1559 14 . . . cord-015306-us58wwmp 1560 1 Results result NNS cord-015306-us58wwmp 1560 2 : : : cord-015306-us58wwmp 1561 1 Compared compare VBN cord-015306-us58wwmp 1561 2 with with IN cord-015306-us58wwmp 1561 3 control control NN cord-015306-us58wwmp 1561 4 group group NN cord-015306-us58wwmp 1561 5 , , , cord-015306-us58wwmp 1561 6 at at IN cord-015306-us58wwmp 1561 7 4 4 CD cord-015306-us58wwmp 1561 8 weeks week NNS cord-015306-us58wwmp 1561 9 , , , cord-015306-us58wwmp 1561 10 24h 24h CD cord-015306-us58wwmp 1561 11 urinary urinary JJ cord-015306-us58wwmp 1561 12 protein protein NN cord-015306-us58wwmp 1561 13 and and CC cord-015306-us58wwmp 1561 14 total total JJ cord-015306-us58wwmp 1561 15 cholesterol cholesterol NN cord-015306-us58wwmp 1561 16 in in IN cord-015306-us58wwmp 1561 17 model model NN cord-015306-us58wwmp 1561 18 group group NN cord-015306-us58wwmp 1561 19 and and CC cord-015306-us58wwmp 1561 20 prednisone prednisone NNP cord-015306-us58wwmp 1561 21 group group NNP cord-015306-us58wwmp 1561 22 were be VBD cord-015306-us58wwmp 1561 23 significantly significantly RB cord-015306-us58wwmp 1561 24 increased(P<0.05),albumin increased(P<0.05),albumin NFP cord-015306-us58wwmp 1561 25 and and CC cord-015306-us58wwmp 1561 26 total total JJ cord-015306-us58wwmp 1561 27 protein protein NN cord-015306-us58wwmp 1561 28 were be VBD cord-015306-us58wwmp 1561 29 significantly significantly RB cord-015306-us58wwmp 1561 30 decreased(P<0.01),which decreased(P<0.01),which -RRB- cord-015306-us58wwmp 1561 31 indicated indicate VBD cord-015306-us58wwmp 1561 32 that that IN cord-015306-us58wwmp 1561 33 the the DT cord-015306-us58wwmp 1561 34 model model NN cord-015306-us58wwmp 1561 35 was be VBD cord-015306-us58wwmp 1561 36 successfully successfully RB cord-015306-us58wwmp 1561 37 established;Compared established;compare VBN cord-015306-us58wwmp 1561 38 with with IN cord-015306-us58wwmp 1561 39 control control NN cord-015306-us58wwmp 1561 40 group group NN cord-015306-us58wwmp 1561 41 , , , cord-015306-us58wwmp 1561 42 at at IN cord-015306-us58wwmp 1561 43 8 8 CD cord-015306-us58wwmp 1561 44 weeks week NNS cord-015306-us58wwmp 1561 45 , , , cord-015306-us58wwmp 1561 46 the the DT cord-015306-us58wwmp 1561 47 expression expression NN cord-015306-us58wwmp 1561 48 of of IN cord-015306-us58wwmp 1561 49 Ezrin Ezrin NNP cord-015306-us58wwmp 1561 50 and and CC cord-015306-us58wwmp 1561 51 NEPH1 NEPH1 NNS cord-015306-us58wwmp 1561 52 in in IN cord-015306-us58wwmp 1561 53 the the DT cord-015306-us58wwmp 1561 54 model model NN cord-015306-us58wwmp 1561 55 group group NN cord-015306-us58wwmp 1561 56 were be VBD cord-015306-us58wwmp 1561 57 significantly significantly RB cord-015306-us58wwmp 1561 58 decreased(P<0.01).Compared decreased(p<0.01).compare VBN cord-015306-us58wwmp 1561 59 with with IN cord-015306-us58wwmp 1561 60 the the DT cord-015306-us58wwmp 1561 61 model model NN cord-015306-us58wwmp 1561 62 group group NN cord-015306-us58wwmp 1561 63 , , , cord-015306-us58wwmp 1561 64 The the DT cord-015306-us58wwmp 1561 65 expression expression NN cord-015306-us58wwmp 1561 66 of of IN cord-015306-us58wwmp 1561 67 Ezrin Ezrin NNP cord-015306-us58wwmp 1561 68 and and CC cord-015306-us58wwmp 1561 69 NEPH1 NEPH1 NNP cord-015306-us58wwmp 1561 70 in in IN cord-015306-us58wwmp 1561 71 prednisone prednisone NNP cord-015306-us58wwmp 1561 72 group group NNP cord-015306-us58wwmp 1561 73 were be VBD cord-015306-us58wwmp 1561 74 significantly significantly RB cord-015306-us58wwmp 1561 75 increased(P<0.01),24h increased(p<0.01),24h JJ cord-015306-us58wwmp 1561 76 urinary urinary JJ cord-015306-us58wwmp 1561 77 protein protein NN cord-015306-us58wwmp 1561 78 and and CC cord-015306-us58wwmp 1561 79 total total JJ cord-015306-us58wwmp 1561 80 cholesterol cholesterol NN cord-015306-us58wwmp 1561 81 were be VBD cord-015306-us58wwmp 1561 82 significantly significantly RB cord-015306-us58wwmp 1561 83 decreased(P<0.01),albumin decreased(p<0.01),albumin CD cord-015306-us58wwmp 1561 84 and and CC cord-015306-us58wwmp 1561 85 total total JJ cord-015306-us58wwmp 1561 86 protein protein NN cord-015306-us58wwmp 1561 87 were be VBD cord-015306-us58wwmp 1561 88 significantly significantly RB cord-015306-us58wwmp 1561 89 increased(P<0.05 increased(p<0.05 JJ cord-015306-us58wwmp 1561 90 ) ) -RRB- cord-015306-us58wwmp 1561 91 , , , cord-015306-us58wwmp 1561 92 renal renal JJ cord-015306-us58wwmp 1561 93 pathology pathology NN cord-015306-us58wwmp 1561 94 and and CC cord-015306-us58wwmp 1561 95 ECM ECM NNP cord-015306-us58wwmp 1561 96 / / SYM cord-015306-us58wwmp 1561 97 GA GA NNP cord-015306-us58wwmp 1561 98 were be VBD cord-015306-us58wwmp 1561 99 significantly significantly RB cord-015306-us58wwmp 1561 100 increased(P<0.01 increased(p<0.01 JJ cord-015306-us58wwmp 1561 101 ) ) -RRB- cord-015306-us58wwmp 1561 102 . . . cord-015306-us58wwmp 1562 1 Conclusion conclusion NN cord-015306-us58wwmp 1562 2 : : : cord-015306-us58wwmp 1562 3 The the DT cord-015306-us58wwmp 1562 4 expression expression NN cord-015306-us58wwmp 1562 5 of of IN cord-015306-us58wwmp 1562 6 Ezrin Ezrin NNP cord-015306-us58wwmp 1562 7 and and CC cord-015306-us58wwmp 1562 8 NEPH1 NEPH1 NNP cord-015306-us58wwmp 1562 9 were be VBD cord-015306-us58wwmp 1562 10 reduced reduce VBN cord-015306-us58wwmp 1562 11 in in IN cord-015306-us58wwmp 1562 12 rats rat NNS cord-015306-us58wwmp 1562 13 with with IN cord-015306-us58wwmp 1562 14 adriamycin adriamycin NN cord-015306-us58wwmp 1562 15 - - HYPH cord-015306-us58wwmp 1562 16 induced induce VBN cord-015306-us58wwmp 1562 17 nephrosis nephrosis NN cord-015306-us58wwmp 1562 18 which which WDT cord-015306-us58wwmp 1562 19 were be VBD cord-015306-us58wwmp 1562 20 negatively negatively RB cord-015306-us58wwmp 1562 21 related relate VBN cord-015306-us58wwmp 1562 22 to to IN cord-015306-us58wwmp 1562 23 proteinuria proteinuria NN cord-015306-us58wwmp 1562 24 and and CC cord-015306-us58wwmp 1562 25 renal renal JJ cord-015306-us58wwmp 1562 26 pathological pathological JJ cord-015306-us58wwmp 1562 27 damage damage NN cord-015306-us58wwmp 1562 28 . . . cord-015306-us58wwmp 1563 1 Prednisone Prednisone NNP cord-015306-us58wwmp 1563 2 can can MD cord-015306-us58wwmp 1563 3 reduce reduce VB cord-015306-us58wwmp 1563 4 the the DT cord-015306-us58wwmp 1563 5 proteinuria proteinuria NN cord-015306-us58wwmp 1563 6 and and CC cord-015306-us58wwmp 1563 7 relieve relieve VB cord-015306-us58wwmp 1563 8 the the DT cord-015306-us58wwmp 1563 9 renal renal JJ cord-015306-us58wwmp 1563 10 pathological pathological JJ cord-015306-us58wwmp 1563 11 damage damage NN cord-015306-us58wwmp 1563 12 by by IN cord-015306-us58wwmp 1563 13 improving improve VBG cord-015306-us58wwmp 1563 14 the the DT cord-015306-us58wwmp 1563 15 expression expression NN cord-015306-us58wwmp 1563 16 of of IN cord-015306-us58wwmp 1563 17 Ezrin Ezrin NNP cord-015306-us58wwmp 1563 18 and and CC cord-015306-us58wwmp 1563 19 NEPH1 NEPH1 NNP cord-015306-us58wwmp 1563 20 . . . cord-015306-us58wwmp 1564 1 Objective objective NN cord-015306-us58wwmp 1564 2 : : : cord-015306-us58wwmp 1565 1 The the DT cord-015306-us58wwmp 1565 2 activation activation NN cord-015306-us58wwmp 1565 3 of of IN cord-015306-us58wwmp 1565 4 the the DT cord-015306-us58wwmp 1565 5 complement complement NN cord-015306-us58wwmp 1565 6 system system NN cord-015306-us58wwmp 1565 7 plays play VBZ cord-015306-us58wwmp 1565 8 an an DT cord-015306-us58wwmp 1565 9 important important JJ cord-015306-us58wwmp 1565 10 role role NN cord-015306-us58wwmp 1565 11 in in IN cord-015306-us58wwmp 1565 12 various various JJ cord-015306-us58wwmp 1565 13 kidney kidney NN cord-015306-us58wwmp 1565 14 diseases disease NNS cord-015306-us58wwmp 1565 15 , , , cord-015306-us58wwmp 1565 16 such such JJ cord-015306-us58wwmp 1565 17 as as IN cord-015306-us58wwmp 1565 18 antibody antibody NN cord-015306-us58wwmp 1565 19 - - HYPH cord-015306-us58wwmp 1565 20 mediated mediate VBN cord-015306-us58wwmp 1565 21 rejection rejection NN cord-015306-us58wwmp 1565 22 or or CC cord-015306-us58wwmp 1565 23 membranous membranous JJ cord-015306-us58wwmp 1565 24 glomerulopathy glomerulopathy NNP cord-015306-us58wwmp 1565 25 . . . cord-015306-us58wwmp 1566 1 The the DT cord-015306-us58wwmp 1566 2 majority majority NN cord-015306-us58wwmp 1566 3 of of IN cord-015306-us58wwmp 1566 4 the the DT cord-015306-us58wwmp 1566 5 circulating circulate VBG cord-015306-us58wwmp 1566 6 complement complement NN cord-015306-us58wwmp 1566 7 components component NNS cord-015306-us58wwmp 1566 8 are be VBP cord-015306-us58wwmp 1566 9 produced produce VBN cord-015306-us58wwmp 1566 10 in in IN cord-015306-us58wwmp 1566 11 the the DT cord-015306-us58wwmp 1566 12 liver liver NN cord-015306-us58wwmp 1566 13 . . . cord-015306-us58wwmp 1567 1 But but CC cord-015306-us58wwmp 1567 2 in in IN cord-015306-us58wwmp 1567 3 the the DT cord-015306-us58wwmp 1567 4 last last JJ cord-015306-us58wwmp 1567 5 decade decade NN cord-015306-us58wwmp 1567 6 the the DT cord-015306-us58wwmp 1567 7 local local JJ cord-015306-us58wwmp 1567 8 production production NN cord-015306-us58wwmp 1567 9 of of IN cord-015306-us58wwmp 1567 10 complement complement JJ cord-015306-us58wwmp 1567 11 components component NNS cord-015306-us58wwmp 1567 12 by by IN cord-015306-us58wwmp 1567 13 other other JJ cord-015306-us58wwmp 1567 14 cells cell NNS cord-015306-us58wwmp 1567 15 is be VBZ cord-015306-us58wwmp 1567 16 highly highly RB cord-015306-us58wwmp 1567 17 debated debate VBN cord-015306-us58wwmp 1567 18 . . . cord-015306-us58wwmp 1568 1 The the DT cord-015306-us58wwmp 1568 2 aim aim NN cord-015306-us58wwmp 1568 3 of of IN cord-015306-us58wwmp 1568 4 our -PRON- PRP$ cord-015306-us58wwmp 1568 5 study study NN cord-015306-us58wwmp 1568 6 was be VBD cord-015306-us58wwmp 1568 7 to to TO cord-015306-us58wwmp 1568 8 proof proof VB cord-015306-us58wwmp 1568 9 the the DT cord-015306-us58wwmp 1568 10 ability ability NN cord-015306-us58wwmp 1568 11 of of IN cord-015306-us58wwmp 1568 12 human human JJ cord-015306-us58wwmp 1568 13 podocytes podocyte NNS cord-015306-us58wwmp 1568 14 to to TO cord-015306-us58wwmp 1568 15 produce produce VB cord-015306-us58wwmp 1568 16 and and CC cord-015306-us58wwmp 1568 17 secrete secrete VB cord-015306-us58wwmp 1568 18 complement complement NN cord-015306-us58wwmp 1568 19 components component NNS cord-015306-us58wwmp 1568 20 . . . cord-015306-us58wwmp 1569 1 Methods method NNS cord-015306-us58wwmp 1569 2 : : : cord-015306-us58wwmp 1569 3 Immortalized immortalize VBN cord-015306-us58wwmp 1569 4 human human JJ cord-015306-us58wwmp 1569 5 podocytes podocyte NNS cord-015306-us58wwmp 1569 6 were be VBD cord-015306-us58wwmp 1569 7 analyzed analyze VBN cord-015306-us58wwmp 1569 8 with with IN cord-015306-us58wwmp 1569 9 Western western JJ cord-015306-us58wwmp 1569 10 Blot Blot NNP cord-015306-us58wwmp 1569 11 ( ( -LRB- cord-015306-us58wwmp 1569 12 WB WB NNP cord-015306-us58wwmp 1569 13 ) ) -RRB- cord-015306-us58wwmp 1569 14 , , , cord-015306-us58wwmp 1569 15 immunofluorescence immunofluorescence NN cord-015306-us58wwmp 1569 16 ( ( -LRB- cord-015306-us58wwmp 1569 17 IF if NN cord-015306-us58wwmp 1569 18 ) ) -RRB- cord-015306-us58wwmp 1569 19 or or CC cord-015306-us58wwmp 1569 20 / / SYM cord-015306-us58wwmp 1569 21 and and CC cord-015306-us58wwmp 1569 22 PCR PCR NNP cord-015306-us58wwmp 1569 23 for for IN cord-015306-us58wwmp 1569 24 their -PRON- PRP$ cord-015306-us58wwmp 1569 25 ability ability NN cord-015306-us58wwmp 1569 26 to to TO cord-015306-us58wwmp 1569 27 produce produce VB cord-015306-us58wwmp 1569 28 components component NNS cord-015306-us58wwmp 1569 29 ( ( -LRB- cord-015306-us58wwmp 1569 30 C1/ C1/ NNP cord-015306-us58wwmp 1569 31 C1q C1q NNP cord-015306-us58wwmp 1569 32 , , , cord-015306-us58wwmp 1569 33 C2 C2 NNP cord-015306-us58wwmp 1569 34 , , , cord-015306-us58wwmp 1569 35 C3 C3 NNP cord-015306-us58wwmp 1569 36 , , , cord-015306-us58wwmp 1569 37 C4 C4 NNP cord-015306-us58wwmp 1569 38 , , , cord-015306-us58wwmp 1569 39 C5 C5 NNP cord-015306-us58wwmp 1569 40 ) ) -RRB- cord-015306-us58wwmp 1569 41 inhibitors inhibitor NNS cord-015306-us58wwmp 1569 42 ( ( -LRB- cord-015306-us58wwmp 1569 43 factor factor NN cord-015306-us58wwmp 1569 44 H H NNP cord-015306-us58wwmp 1569 45 , , , cord-015306-us58wwmp 1569 46 MCP MCP NNP cord-015306-us58wwmp 1569 47 , , , cord-015306-us58wwmp 1569 48 CD CD NNP cord-015306-us58wwmp 1569 49 55 55 CD cord-015306-us58wwmp 1569 50 , , , cord-015306-us58wwmp 1569 51 CD59 CD59 NNP cord-015306-us58wwmp 1569 52 ) ) -RRB- cord-015306-us58wwmp 1569 53 and and CC cord-015306-us58wwmp 1569 54 activators activator NNS cord-015306-us58wwmp 1569 55 ( ( -LRB- cord-015306-us58wwmp 1569 56 factor factor NN cord-015306-us58wwmp 1569 57 B b NN cord-015306-us58wwmp 1569 58 , , , cord-015306-us58wwmp 1569 59 properdin properdin NNP cord-015306-us58wwmp 1569 60 ) ) -RRB- cord-015306-us58wwmp 1569 61 of of IN cord-015306-us58wwmp 1569 62 the the DT cord-015306-us58wwmp 1569 63 complement complement JJ cord-015306-us58wwmp 1569 64 system system NN cord-015306-us58wwmp 1569 65 . . . cord-015306-us58wwmp 1570 1 Secretion secretion NN cord-015306-us58wwmp 1570 2 of of IN cord-015306-us58wwmp 1570 3 components component NNS cord-015306-us58wwmp 1570 4 was be VBD cord-015306-us58wwmp 1570 5 measured measure VBN cord-015306-us58wwmp 1570 6 in in IN cord-015306-us58wwmp 1570 7 the the DT cord-015306-us58wwmp 1570 8 medium medium NN cord-015306-us58wwmp 1570 9 , , , cord-015306-us58wwmp 1570 10 and and CC cord-015306-us58wwmp 1570 11 functionality functionality NN cord-015306-us58wwmp 1570 12 of of IN cord-015306-us58wwmp 1570 13 C3 C3 NNP cord-015306-us58wwmp 1570 14 was be VBD cord-015306-us58wwmp 1570 15 tested test VBN cord-015306-us58wwmp 1570 16 in in IN cord-015306-us58wwmp 1570 17 a a DT cord-015306-us58wwmp 1570 18 specific specific JJ cord-015306-us58wwmp 1570 19 C3convertase c3convertase NN cord-015306-us58wwmp 1570 20 assay assay NN cord-015306-us58wwmp 1570 21 . . . cord-015306-us58wwmp 1571 1 Stimulation stimulation NN cord-015306-us58wwmp 1571 2 of of IN cord-015306-us58wwmp 1571 3 the the DT cord-015306-us58wwmp 1571 4 cells cell NNS cord-015306-us58wwmp 1571 5 was be VBD cord-015306-us58wwmp 1571 6 done do VBN cord-015306-us58wwmp 1571 7 with with IN cord-015306-us58wwmp 1571 8 interferon interferon NN cord-015306-us58wwmp 1571 9 - - HYPH cord-015306-us58wwmp 1571 10 γ γ NN cord-015306-us58wwmp 1571 11 , , , cord-015306-us58wwmp 1571 12 interleukin interleukin NN cord-015306-us58wwmp 1571 13 6 6 CD cord-015306-us58wwmp 1571 14 and and CC cord-015306-us58wwmp 1571 15 human human JJ cord-015306-us58wwmp 1571 16 albumin albumin NN cord-015306-us58wwmp 1571 17 . . . cord-015306-us58wwmp 1572 1 Results result NNS cord-015306-us58wwmp 1572 2 : : : cord-015306-us58wwmp 1573 1 PCR PCR NNP cord-015306-us58wwmp 1573 2 - - HYPH cord-015306-us58wwmp 1573 3 studies study NNS cord-015306-us58wwmp 1573 4 revealed reveal VBD cord-015306-us58wwmp 1573 5 that that IN cord-015306-us58wwmp 1573 6 human human JJ cord-015306-us58wwmp 1573 7 podocytes podocytes NNPS cord-015306-us58wwmp 1573 8 express express NNP cord-015306-us58wwmp 1573 9 on on IN cord-015306-us58wwmp 1573 10 mRNA mRNA NNP cord-015306-us58wwmp 1573 11 level level NN cord-015306-us58wwmp 1573 12 the the DT cord-015306-us58wwmp 1573 13 components component NNS cord-015306-us58wwmp 1573 14 C2 C2 NNP cord-015306-us58wwmp 1573 15 , , , cord-015306-us58wwmp 1573 16 C3 C3 NNP cord-015306-us58wwmp 1573 17 , , , cord-015306-us58wwmp 1573 18 C4 C4 NNP cord-015306-us58wwmp 1573 19 , , , cord-015306-us58wwmp 1573 20 C5 C5 NNP cord-015306-us58wwmp 1573 21 , , , cord-015306-us58wwmp 1573 22 the the DT cord-015306-us58wwmp 1573 23 inhibitors inhibitor NNS cord-015306-us58wwmp 1573 24 factor factor NN cord-015306-us58wwmp 1573 25 H H NNP cord-015306-us58wwmp 1573 26 , , , cord-015306-us58wwmp 1573 27 MCP MCP NNP cord-015306-us58wwmp 1573 28 , , , cord-015306-us58wwmp 1573 29 CD CD NNP cord-015306-us58wwmp 1573 30 55 55 CD cord-015306-us58wwmp 1573 31 and and CC cord-015306-us58wwmp 1573 32 CD59 CD59 NNP cord-015306-us58wwmp 1573 33 , , , cord-015306-us58wwmp 1573 34 and and CC cord-015306-us58wwmp 1573 35 the the DT cord-015306-us58wwmp 1573 36 activators activator NNS cord-015306-us58wwmp 1573 37 properdin properdin NN cord-015306-us58wwmp 1573 38 and and CC cord-015306-us58wwmp 1573 39 factor factor NN cord-015306-us58wwmp 1574 1 B. B. NNP cord-015306-us58wwmp 1575 1 On on IN cord-015306-us58wwmp 1575 2 protein protein NN cord-015306-us58wwmp 1575 3 levels level NNS cord-015306-us58wwmp 1575 4 C2 C2 NNP cord-015306-us58wwmp 1575 5 , , , cord-015306-us58wwmp 1575 6 C3 C3 NNP cord-015306-us58wwmp 1575 7 , , , cord-015306-us58wwmp 1575 8 factor factor NN cord-015306-us58wwmp 1575 9 B b NN cord-015306-us58wwmp 1575 10 , , , cord-015306-us58wwmp 1575 11 properdin properdin NNP cord-015306-us58wwmp 1575 12 , , , cord-015306-us58wwmp 1575 13 factor factor NN cord-015306-us58wwmp 1575 14 H h NN cord-015306-us58wwmp 1575 15 , , , cord-015306-us58wwmp 1575 16 CD CD NNP cord-015306-us58wwmp 1575 17 55 55 CD cord-015306-us58wwmp 1575 18 and and CC cord-015306-us58wwmp 1575 19 CD59 CD59 NNP cord-015306-us58wwmp 1575 20 were be VBD cord-015306-us58wwmp 1575 21 detected detect VBN cord-015306-us58wwmp 1575 22 . . . cord-015306-us58wwmp 1576 1 In in IN cord-015306-us58wwmp 1576 2 immunofluorescence immunofluorescence NN cord-015306-us58wwmp 1576 3 all all PDT cord-015306-us58wwmp 1576 4 the the DT cord-015306-us58wwmp 1576 5 components component NNS cord-015306-us58wwmp 1576 6 showed show VBD cord-015306-us58wwmp 1576 7 either either CC cord-015306-us58wwmp 1576 8 intra intra JJ cord-015306-us58wwmp 1576 9 - - JJ cord-015306-us58wwmp 1576 10 plasmatic plasmatic JJ cord-015306-us58wwmp 1576 11 , , , cord-015306-us58wwmp 1576 12 perinuclear perinuclear NNP cord-015306-us58wwmp 1576 13 or or CC cord-015306-us58wwmp 1576 14 peri peri JJ cord-015306-us58wwmp 1576 15 - - HYPH cord-015306-us58wwmp 1576 16 membranous membranous JJ cord-015306-us58wwmp 1576 17 distribution distribution NN cord-015306-us58wwmp 1576 18 . . . cord-015306-us58wwmp 1577 1 In in IN cord-015306-us58wwmp 1577 2 addition addition NN cord-015306-us58wwmp 1577 3 , , , cord-015306-us58wwmp 1577 4 we -PRON- PRP cord-015306-us58wwmp 1577 5 could could MD cord-015306-us58wwmp 1577 6 show show VB cord-015306-us58wwmp 1577 7 that that IN cord-015306-us58wwmp 1577 8 podocytes podocyte NNS cord-015306-us58wwmp 1577 9 secrete secrete VBP cord-015306-us58wwmp 1577 10 the the DT cord-015306-us58wwmp 1577 11 factors factor NNS cord-015306-us58wwmp 1577 12 C2 C2 NNP cord-015306-us58wwmp 1577 13 , , , cord-015306-us58wwmp 1577 14 C3 C3 NNP cord-015306-us58wwmp 1577 15 , , , cord-015306-us58wwmp 1577 16 C4 C4 NNP cord-015306-us58wwmp 1577 17 , , , cord-015306-us58wwmp 1577 18 C5 C5 NNP cord-015306-us58wwmp 1577 19 , , , cord-015306-us58wwmp 1577 20 factor factor NN cord-015306-us58wwmp 1577 21 B b NN cord-015306-us58wwmp 1577 22 and and CC cord-015306-us58wwmp 1577 23 factor factor NN cord-015306-us58wwmp 1577 24 H h NN cord-015306-us58wwmp 1577 25 into into IN cord-015306-us58wwmp 1577 26 the the DT cord-015306-us58wwmp 1577 27 medium medium NN cord-015306-us58wwmp 1577 28 . . . cord-015306-us58wwmp 1578 1 The the DT cord-015306-us58wwmp 1578 2 secreted secrete VBN cord-015306-us58wwmp 1578 3 C3 c3 NN cord-015306-us58wwmp 1578 4 was be VBD cord-015306-us58wwmp 1578 5 clearly clearly RB cord-015306-us58wwmp 1578 6 functionally functionally RB cord-015306-us58wwmp 1578 7 active active JJ cord-015306-us58wwmp 1578 8 and and CC cord-015306-us58wwmp 1578 9 could could MD cord-015306-us58wwmp 1578 10 further further RB cord-015306-us58wwmp 1578 11 enhanced enhance VBN cord-015306-us58wwmp 1578 12 by by IN cord-015306-us58wwmp 1578 13 stimulation stimulation NN cord-015306-us58wwmp 1578 14 with with IN cord-015306-us58wwmp 1578 15 interferon interferon NN cord-015306-us58wwmp 1578 16 - - HYPH cord-015306-us58wwmp 1578 17 γ γ NN cord-015306-us58wwmp 1578 18 . . . cord-015306-us58wwmp 1579 1 Objective objective NN cord-015306-us58wwmp 1579 2 : : : cord-015306-us58wwmp 1580 1 To to TO cord-015306-us58wwmp 1580 2 construct construct VB cord-015306-us58wwmp 1580 3 the the DT cord-015306-us58wwmp 1580 4 eukaryotic eukaryotic JJ cord-015306-us58wwmp 1580 5 expression expression NN cord-015306-us58wwmp 1580 6 plasmid plasmid NN cord-015306-us58wwmp 1580 7 and and CC cord-015306-us58wwmp 1580 8 its -PRON- PRP$ cord-015306-us58wwmp 1580 9 shRNA shrna NN cord-015306-us58wwmp 1580 10 plasmids plasmid NNS cord-015306-us58wwmp 1580 11 of of IN cord-015306-us58wwmp 1580 12 IL-17 IL-17 NNP cord-015306-us58wwmp 1580 13 of of IN cord-015306-us58wwmp 1580 14 mice mouse NNS cord-015306-us58wwmp 1580 15 , , , cord-015306-us58wwmp 1580 16 and and CC cord-015306-us58wwmp 1580 17 to to TO cord-015306-us58wwmp 1580 18 investigate investigate VB cord-015306-us58wwmp 1580 19 their -PRON- PRP$ cord-015306-us58wwmp 1580 20 ability ability NN cord-015306-us58wwmp 1580 21 of of IN cord-015306-us58wwmp 1580 22 expression expression NN cord-015306-us58wwmp 1580 23 or or CC cord-015306-us58wwmp 1580 24 inhibitory inhibitory JJ cord-015306-us58wwmp 1580 25 effects effect NNS cord-015306-us58wwmp 1580 26 on on IN cord-015306-us58wwmp 1580 27 IL-17 IL-17 NNP cord-015306-us58wwmp 1580 28 . . . cord-015306-us58wwmp 1581 1 Methods method NNS cord-015306-us58wwmp 1581 2 : : : cord-015306-us58wwmp 1582 1 The the DT cord-015306-us58wwmp 1582 2 RNA RNA NNP cord-015306-us58wwmp 1582 3 from from IN cord-015306-us58wwmp 1582 4 spleen spleen NN cord-015306-us58wwmp 1582 5 cells cell NNS cord-015306-us58wwmp 1582 6 of of IN cord-015306-us58wwmp 1582 7 Bal Bal NNP cord-015306-us58wwmp 1582 8 b b NNP cord-015306-us58wwmp 1582 9 / / SYM cord-015306-us58wwmp 1582 10 c c NN cord-015306-us58wwmp 1582 11 mouse mouse NN cord-015306-us58wwmp 1582 12 was be VBD cord-015306-us58wwmp 1582 13 reversed reverse VBN cord-015306-us58wwmp 1582 14 to to IN cord-015306-us58wwmp 1582 15 cDNA cdna NN cord-015306-us58wwmp 1582 16 , , , cord-015306-us58wwmp 1582 17 and and CC cord-015306-us58wwmp 1582 18 the the DT cord-015306-us58wwmp 1582 19 full full JJ cord-015306-us58wwmp 1582 20 - - HYPH cord-015306-us58wwmp 1582 21 length length NN cord-015306-us58wwmp 1582 22 CDS cds NN cord-015306-us58wwmp 1582 23 fragment fragment NN cord-015306-us58wwmp 1582 24 of of IN cord-015306-us58wwmp 1582 25 IL-17 IL-17 NNP cord-015306-us58wwmp 1582 26 was be VBD cord-015306-us58wwmp 1582 27 amplified amplify VBN cord-015306-us58wwmp 1582 28 . . . cord-015306-us58wwmp 1583 1 The the DT cord-015306-us58wwmp 1583 2 target target NN cord-015306-us58wwmp 1583 3 segment segment NN cord-015306-us58wwmp 1583 4 was be VBD cord-015306-us58wwmp 1583 5 cloned clone VBN cord-015306-us58wwmp 1583 6 into into IN cord-015306-us58wwmp 1583 7 the the DT cord-015306-us58wwmp 1583 8 expression expression NN cord-015306-us58wwmp 1583 9 vector vector NN cord-015306-us58wwmp 1583 10 pLVX plvx XX cord-015306-us58wwmp 1583 11 - - HYPH cord-015306-us58wwmp 1583 12 IRES IRES NNP cord-015306-us58wwmp 1583 13 - - HYPH cord-015306-us58wwmp 1583 14 ZsGreen1 ZsGreen1 NNS cord-015306-us58wwmp 1583 15 , , , cord-015306-us58wwmp 1583 16 then then RB cord-015306-us58wwmp 1583 17 , , , cord-015306-us58wwmp 1583 18 the the DT cord-015306-us58wwmp 1583 19 recombinant recombinant JJ cord-015306-us58wwmp 1583 20 plasmid plasmid NN cord-015306-us58wwmp 1583 21 pLVX pLVX VBN cord-015306-us58wwmp 1583 22 - - JJ cord-015306-us58wwmp 1583 23 IL-17-IRES IL-17-IRES NNP cord-015306-us58wwmp 1583 24 - - HYPH cord-015306-us58wwmp 1583 25 ZsGreen1 zsgreen1 CD cord-015306-us58wwmp 1583 26 was be VBD cord-015306-us58wwmp 1583 27 obtained obtain VBN cord-015306-us58wwmp 1583 28 . . . cord-015306-us58wwmp 1584 1 Three three CD cord-015306-us58wwmp 1584 2 pairs pair NNS cord-015306-us58wwmp 1584 3 of of IN cord-015306-us58wwmp 1584 4 shRNA shrna NN cord-015306-us58wwmp 1584 5 chains chain NNS cord-015306-us58wwmp 1584 6 targeting target VBG cord-015306-us58wwmp 1584 7 IL-17 IL-17 NNP cord-015306-us58wwmp 1584 8 gene gene NN cord-015306-us58wwmp 1584 9 and and CC cord-015306-us58wwmp 1584 10 one one CD cord-015306-us58wwmp 1584 11 pair pair NN cord-015306-us58wwmp 1584 12 control control NN cord-015306-us58wwmp 1584 13 shRNA shrna NN cord-015306-us58wwmp 1584 14 chain chain NN cord-015306-us58wwmp 1584 15 were be VBD cord-015306-us58wwmp 1584 16 designed design VBN cord-015306-us58wwmp 1584 17 and and CC cord-015306-us58wwmp 1584 18 synthesized synthesize VBN cord-015306-us58wwmp 1584 19 , , , cord-015306-us58wwmp 1584 20 then then RB cord-015306-us58wwmp 1584 21 annealed anneal VBN cord-015306-us58wwmp 1584 22 to to TO cord-015306-us58wwmp 1584 23 form form VB cord-015306-us58wwmp 1584 24 double double JJ cord-015306-us58wwmp 1584 25 strand strand NN cord-015306-us58wwmp 1584 26 , , , cord-015306-us58wwmp 1584 27 and and CC cord-015306-us58wwmp 1584 28 inserted insert VBD cord-015306-us58wwmp 1584 29 into into IN cord-015306-us58wwmp 1584 30 the the DT cord-015306-us58wwmp 1584 31 expression expression NN cord-015306-us58wwmp 1584 32 vector vector NN cord-015306-us58wwmp 1584 33 pLVX plvx XX cord-015306-us58wwmp 1584 34 - - HYPH cord-015306-us58wwmp 1584 35 shRNA2 shrna2 JJ cord-015306-us58wwmp 1584 36 . . . cord-015306-us58wwmp 1585 1 three three CD cord-015306-us58wwmp 1585 2 shRNA shrna NN cord-015306-us58wwmp 1585 3 plasmids plasmid NNS cord-015306-us58wwmp 1585 4 and and CC cord-015306-us58wwmp 1585 5 one one CD cord-015306-us58wwmp 1585 6 control control NN cord-015306-us58wwmp 1585 7 plasmid plasmid NN cord-015306-us58wwmp 1585 8 were be VBD cord-015306-us58wwmp 1585 9 constructed construct VBN cord-015306-us58wwmp 1585 10 , , , cord-015306-us58wwmp 1585 11 which which WDT cord-015306-us58wwmp 1585 12 were be VBD cord-015306-us58wwmp 1585 13 called call VBN cord-015306-us58wwmp 1585 14 ShRNA1 ShRNA1 NNP cord-015306-us58wwmp 1585 15 / / SYM cord-015306-us58wwmp 1585 16 ShRNA2 ShRNA2 NNP cord-015306-us58wwmp 1585 17 / / SYM cord-015306-us58wwmp 1585 18 ShRNA3 ShRNA3 NNP cord-015306-us58wwmp 1585 19 / / SYM cord-015306-us58wwmp 1585 20 ShRNAC ShRNAC NNP cord-015306-us58wwmp 1585 21 , , , cord-015306-us58wwmp 1585 22 respectively respectively RB cord-015306-us58wwmp 1585 23 . . . cord-015306-us58wwmp 1586 1 These these DT cord-015306-us58wwmp 1586 2 plasmids plasmid NNS cord-015306-us58wwmp 1586 3 were be VBD cord-015306-us58wwmp 1586 4 identified identify VBN cord-015306-us58wwmp 1586 5 by by IN cord-015306-us58wwmp 1586 6 restriction restriction NN cord-015306-us58wwmp 1586 7 analysis analysis NN cord-015306-us58wwmp 1586 8 and and CC cord-015306-us58wwmp 1586 9 sequencing sequencing NN cord-015306-us58wwmp 1586 10 , , , cord-015306-us58wwmp 1586 11 and and CC cord-015306-us58wwmp 1586 12 then then RB cord-015306-us58wwmp 1586 13 they -PRON- PRP cord-015306-us58wwmp 1586 14 were be VBD cord-015306-us58wwmp 1586 15 transfected transfecte VBN cord-015306-us58wwmp 1586 16 or or CC cord-015306-us58wwmp 1586 17 co co NNS cord-015306-us58wwmp 1586 18 - - VBN cord-015306-us58wwmp 1586 19 transfected transfecte VBN cord-015306-us58wwmp 1586 20 into into IN cord-015306-us58wwmp 1586 21 293 293 CD cord-015306-us58wwmp 1586 22 T T NNP cord-015306-us58wwmp 1586 23 cells cell NNS cord-015306-us58wwmp 1586 24 in in IN cord-015306-us58wwmp 1586 25 mediation mediation NN cord-015306-us58wwmp 1586 26 of of IN cord-015306-us58wwmp 1586 27 liposome liposome NN cord-015306-us58wwmp 1586 28 . . . cord-015306-us58wwmp 1587 1 The the DT cord-015306-us58wwmp 1587 2 transcription transcription NN cord-015306-us58wwmp 1587 3 levels level NNS cord-015306-us58wwmp 1587 4 of of IN cord-015306-us58wwmp 1587 5 IL-17 IL-17 NNP cord-015306-us58wwmp 1587 6 mRNA mRNA NNP cord-015306-us58wwmp 1587 7 were be VBD cord-015306-us58wwmp 1587 8 detected detect VBN cord-015306-us58wwmp 1587 9 by by IN cord-015306-us58wwmp 1587 10 fluorescent fluorescent JJ cord-015306-us58wwmp 1587 11 quantitative quantitative JJ cord-015306-us58wwmp 1587 12 PCR PCR NNP cord-015306-us58wwmp 1587 13 , , , cord-015306-us58wwmp 1587 14 while while IN cord-015306-us58wwmp 1587 15 expression expression NN cord-015306-us58wwmp 1587 16 levels level NNS cord-015306-us58wwmp 1587 17 of of IN cord-015306-us58wwmp 1587 18 IL-17 IL-17 NNP cord-015306-us58wwmp 1587 19 protein protein NN cord-015306-us58wwmp 1587 20 were be VBD cord-015306-us58wwmp 1587 21 detected detect VBN cord-015306-us58wwmp 1587 22 by by IN cord-015306-us58wwmp 1587 23 ELISA ELISA NNP cord-015306-us58wwmp 1587 24 . . . cord-015306-us58wwmp 1588 1 Results result NNS cord-015306-us58wwmp 1588 2 : : : cord-015306-us58wwmp 1589 1 Restriction restriction NN cord-015306-us58wwmp 1589 2 analysis analysis NN cord-015306-us58wwmp 1589 3 and and CC cord-015306-us58wwmp 1589 4 sequencing sequencing NN cord-015306-us58wwmp 1589 5 proved prove VBD cord-015306-us58wwmp 1589 6 that that IN cord-015306-us58wwmp 1589 7 the the DT cord-015306-us58wwmp 1589 8 recombinant recombinant JJ cord-015306-us58wwmp 1589 9 plasmid plasmid NN cord-015306-us58wwmp 1589 10 were be VBD cord-015306-us58wwmp 1589 11 constructed construct VBN cord-015306-us58wwmp 1589 12 correctly correctly RB cord-015306-us58wwmp 1589 13 . . . cord-015306-us58wwmp 1590 1 The the DT cord-015306-us58wwmp 1590 2 plasmid plasmid NN cord-015306-us58wwmp 1590 3 of of IN cord-015306-us58wwmp 1590 4 pLVX plvx JJ cord-015306-us58wwmp 1590 5 - - JJ cord-015306-us58wwmp 1590 6 IL-17-IRES IL-17-IRES NNP cord-015306-us58wwmp 1590 7 - - HYPH cord-015306-us58wwmp 1590 8 ZsG ZsG NNP cord-015306-us58wwmp 1590 9 reen1 reen1 NN cord-015306-us58wwmp 1590 10 could could MD cord-015306-us58wwmp 1590 11 expression expression VB cord-015306-us58wwmp 1590 12 IL-17 IL-17 NNP cord-015306-us58wwmp 1590 13 ; ; : cord-015306-us58wwmp 1590 14 when when WRB cord-015306-us58wwmp 1590 15 cotransfected cotransfecte VBN cord-015306-us58wwmp 1590 16 with with IN cord-015306-us58wwmp 1590 17 expression expression NN cord-015306-us58wwmp 1590 18 plasmid plasmid NN cord-015306-us58wwmp 1590 19 , , , cord-015306-us58wwmp 1590 20 IL-17 IL-17 NNP cord-015306-us58wwmp 1590 21 expression expression NN cord-015306-us58wwmp 1590 22 levels level NNS cord-015306-us58wwmp 1590 23 were be VBD cord-015306-us58wwmp 1590 24 significantly significantly RB cord-015306-us58wwmp 1590 25 reduced reduce VBN cord-015306-us58wwmp 1590 26 in in IN cord-015306-us58wwmp 1590 27 the the DT cord-015306-us58wwmp 1590 28 group group NN cord-015306-us58wwmp 1590 29 of of IN cord-015306-us58wwmp 1590 30 ShRNA1 ShRNA1 NNP cord-015306-us58wwmp 1590 31 / / SYM cord-015306-us58wwmp 1590 32 ShRNA2 ShRNA2 NNP cord-015306-us58wwmp 1590 33 / / SYM cord-015306-us58wwmp 1590 34 ShRNA3 shrna3 NN cord-015306-us58wwmp 1590 35 as as IN cord-015306-us58wwmp 1590 36 compared compare VBN cord-015306-us58wwmp 1590 37 with with IN cord-015306-us58wwmp 1590 38 the the DT cord-015306-us58wwmp 1590 39 ShRNAC ShRNAC NNP cord-015306-us58wwmp 1590 40 group group NN cord-015306-us58wwmp 1590 41 , , , cord-015306-us58wwmp 1590 42 and and CC cord-015306-us58wwmp 1590 43 the the DT cord-015306-us58wwmp 1590 44 group group NN cord-015306-us58wwmp 1590 45 of of IN cord-015306-us58wwmp 1590 46 ShRNA1 ShRNA1 NNP cord-015306-us58wwmp 1590 47 had have VBD cord-015306-us58wwmp 1590 48 the the DT cord-015306-us58wwmp 1590 49 least least JJS cord-015306-us58wwmp 1590 50 expression expression NN cord-015306-us58wwmp 1590 51 . . . cord-015306-us58wwmp 1591 1 Conclusion conclusion NN cord-015306-us58wwmp 1591 2 : : : cord-015306-us58wwmp 1591 3 IL-17 IL-17 NNP cord-015306-us58wwmp 1591 4 eukaryotic eukaryotic JJ cord-015306-us58wwmp 1591 5 expression expression NN cord-015306-us58wwmp 1591 6 plasmid plasmid NN cord-015306-us58wwmp 1591 7 and and CC cord-015306-us58wwmp 1591 8 its -PRON- PRP$ cord-015306-us58wwmp 1591 9 specific specific JJ cord-015306-us58wwmp 1591 10 ShRNA ShRNA NNP cord-015306-us58wwmp 1591 11 plasmids plasmid NNS cord-015306-us58wwmp 1591 12 were be VBD cord-015306-us58wwmp 1591 13 constructed construct VBN cord-015306-us58wwmp 1591 14 successfully successfully RB cord-015306-us58wwmp 1591 15 , , , cord-015306-us58wwmp 1591 16 and and CC cord-015306-us58wwmp 1591 17 plasmid plasmid NNP cord-015306-us58wwmp 1591 18 ShRNA1 ShRNA1 NNP cord-015306-us58wwmp 1591 19 had have VBD cord-015306-us58wwmp 1591 20 the the DT cord-015306-us58wwmp 1591 21 best good JJS cord-015306-us58wwmp 1591 22 inhibitory inhibitory JJ cord-015306-us58wwmp 1591 23 effects effect NNS cord-015306-us58wwmp 1591 24 . . . cord-015306-us58wwmp 1592 1 Abstract abstract JJ cord-015306-us58wwmp 1592 2 # # NN cord-015306-us58wwmp 1592 3 P p NN cord-015306-us58wwmp 1592 4 - - HYPH cord-015306-us58wwmp 1592 5 SAT195 SAT195 NNP cord-015306-us58wwmp 1592 6 Reno Reno NNP cord-015306-us58wwmp 1592 7 - - HYPH cord-015306-us58wwmp 1592 8 protective protective JJ cord-015306-us58wwmp 1592 9 Effect effect NN cord-015306-us58wwmp 1592 10 of of IN cord-015306-us58wwmp 1592 11 All all RB cord-015306-us58wwmp 1592 12 - - HYPH cord-015306-us58wwmp 1592 13 trans trans NNP cord-015306-us58wwmp 1592 14 Retinoic Retinoic NNP cord-015306-us58wwmp 1592 15 Acid Acid NNP cord-015306-us58wwmp 1592 16 on on IN cord-015306-us58wwmp 1592 17 Adriamycininduced Adriamycininduced NNP cord-015306-us58wwmp 1592 18 Nephropathy Nephropathy NNP cord-015306-us58wwmp 1592 19 Mice Mice NNP cord-015306-us58wwmp 1592 20 Xiaoli Xiaoli NNP cord-015306-us58wwmp 1592 21 Wang Wang NNP cord-015306-us58wwmp 1592 22 , , , cord-015306-us58wwmp 1592 23 Jingjing Jingjing NNP cord-015306-us58wwmp 1592 24 Cui Cui NNP cord-015306-us58wwmp 1592 25 , , , cord-015306-us58wwmp 1592 26 Qiu Qiu NNP cord-015306-us58wwmp 1592 27 Li Li NNP cord-015306-us58wwmp 1592 28 Nephrology Nephrology NNP cord-015306-us58wwmp 1592 29 and and CC cord-015306-us58wwmp 1592 30 immunology immunology NNP cord-015306-us58wwmp 1592 31 department department NN cord-015306-us58wwmp 1592 32 , , , cord-015306-us58wwmp 1592 33 children child NNS cord-015306-us58wwmp 1592 34 's 's POS cord-015306-us58wwmp 1592 35 hospital hospital NN cord-015306-us58wwmp 1592 36 of of IN cord-015306-us58wwmp 1592 37 Chongqing Chongqing NNP cord-015306-us58wwmp 1592 38 medical medical JJ cord-015306-us58wwmp 1592 39 university university NN cord-015306-us58wwmp 1592 40 , , , cord-015306-us58wwmp 1592 41 Chongqing Chongqing NNP cord-015306-us58wwmp 1592 42 , , , cord-015306-us58wwmp 1593 1 China China NNP cord-015306-us58wwmp 1593 2 Objective Objective NNP cord-015306-us58wwmp 1593 3 : : : cord-015306-us58wwmp 1593 4 To to TO cord-015306-us58wwmp 1593 5 investigate investigate VB cord-015306-us58wwmp 1593 6 the the DT cord-015306-us58wwmp 1593 7 reno reno NNP cord-015306-us58wwmp 1593 8 - - HYPH cord-015306-us58wwmp 1593 9 protective protective JJ cord-015306-us58wwmp 1593 10 effect effect NN cord-015306-us58wwmp 1593 11 of of IN cord-015306-us58wwmp 1593 12 All all RB cord-015306-us58wwmp 1593 13 - - HYPH cord-015306-us58wwmp 1593 14 trans trans NNP cord-015306-us58wwmp 1593 15 Retinoic Retinoic NNP cord-015306-us58wwmp 1593 16 Acid Acid NNP cord-015306-us58wwmp 1593 17 on on IN cord-015306-us58wwmp 1593 18 Adriamycin adriamycin NN cord-015306-us58wwmp 1593 19 - - HYPH cord-015306-us58wwmp 1593 20 induced induce VBN cord-015306-us58wwmp 1593 21 Nephropathy Nephropathy NNP cord-015306-us58wwmp 1593 22 mice mouse NNS cord-015306-us58wwmp 1593 23 . . . cord-015306-us58wwmp 1594 1 Methods method NNS cord-015306-us58wwmp 1594 2 : : : cord-015306-us58wwmp 1595 1 BALB BALB NNP cord-015306-us58wwmp 1595 2 / / SYM cord-015306-us58wwmp 1595 3 C C NNP cord-015306-us58wwmp 1595 4 mice mouse NNS cord-015306-us58wwmp 1595 5 were be VBD cord-015306-us58wwmp 1595 6 randomly randomly RB cord-015306-us58wwmp 1595 7 divided divide VBN cord-015306-us58wwmp 1595 8 into into IN cord-015306-us58wwmp 1595 9 nephrosis(a nephrosis(a DT cord-015306-us58wwmp 1595 10 single single JJ cord-015306-us58wwmp 1595 11 adriamycin adriamycin NNS cord-015306-us58wwmp 1595 12 10.5mg 10.5mg CD cord-015306-us58wwmp 1595 13 / / SYM cord-015306-us58wwmp 1595 14 kg kg NNP cord-015306-us58wwmp 1595 15 , , , cord-015306-us58wwmp 1595 16 n=20 n=20 NNP cord-015306-us58wwmp 1595 17 ) ) -RRB- cord-015306-us58wwmp 1595 18 and and CC cord-015306-us58wwmp 1595 19 control(tail control(tail JJ cord-015306-us58wwmp 1595 20 intravenous intravenous JJ cord-015306-us58wwmp 1595 21 injection injection NN cord-015306-us58wwmp 1595 22 the the DT cord-015306-us58wwmp 1595 23 same same JJ cord-015306-us58wwmp 1595 24 amount amount NN cord-015306-us58wwmp 1595 25 of of IN cord-015306-us58wwmp 1595 26 saline saline NN cord-015306-us58wwmp 1595 27 , , , cord-015306-us58wwmp 1595 28 n=10 n=10 NNP cord-015306-us58wwmp 1595 29 ) ) -RRB- cord-015306-us58wwmp 1595 30 . . . cord-015306-us58wwmp 1596 1 After after IN cord-015306-us58wwmp 1596 2 two two CD cord-015306-us58wwmp 1596 3 weeks week NNS cord-015306-us58wwmp 1596 4 nephrosis nephrosis NN cord-015306-us58wwmp 1596 5 divided divide VBN cord-015306-us58wwmp 1596 6 into into IN cord-015306-us58wwmp 1596 7 ATRA ATRA NNP cord-015306-us58wwmp 1596 8 - - HYPH cord-015306-us58wwmp 1596 9 treated(intraperitoneal treated(intraperitoneal NN cord-015306-us58wwmp 1596 10 injection injection NN cord-015306-us58wwmp 1597 1 All all DT cord-015306-us58wwmp 1597 2 - - HYPH cord-015306-us58wwmp 1597 3 trans trans NNP cord-015306-us58wwmp 1597 4 Retinoic Retinoic NNP cord-015306-us58wwmp 1597 5 Acid Acid NNP cord-015306-us58wwmp 1597 6 20mg 20mg NNP cord-015306-us58wwmp 1597 7 / / SYM cord-015306-us58wwmp 1597 8 kg kg NNS cord-015306-us58wwmp 1597 9 , , , cord-015306-us58wwmp 1597 10 three three CD cord-015306-us58wwmp 1597 11 times time NNS cord-015306-us58wwmp 1597 12 a a DT cord-015306-us58wwmp 1597 13 week week NN cord-015306-us58wwmp 1597 14 , , , cord-015306-us58wwmp 1597 15 n=10 n=10 NNP cord-015306-us58wwmp 1597 16 ) ) -RRB- cord-015306-us58wwmp 1597 17 and and CC cord-015306-us58wwmp 1597 18 ADR ADR NNP cord-015306-us58wwmp 1597 19 nephrosis nephrosis NN cord-015306-us58wwmp 1597 20 . . . cord-015306-us58wwmp 1598 1 Then then RB cord-015306-us58wwmp 1598 2 , , , cord-015306-us58wwmp 1598 3 we -PRON- PRP cord-015306-us58wwmp 1598 4 chose choose VBD cord-015306-us58wwmp 1598 5 five five CD cord-015306-us58wwmp 1598 6 mice mouse NNS cord-015306-us58wwmp 1598 7 each each DT cord-015306-us58wwmp 1598 8 group group NN cord-015306-us58wwmp 1598 9 randomly randomly RB cord-015306-us58wwmp 1598 10 after after IN cord-015306-us58wwmp 1598 11 treatment treatment NN cord-015306-us58wwmp 1598 12 6 6 CD cord-015306-us58wwmp 1598 13 weeks week NNS cord-015306-us58wwmp 1598 14 and and CC cord-015306-us58wwmp 1598 15 10 10 CD cord-015306-us58wwmp 1598 16 weeks week NNS cord-015306-us58wwmp 1598 17 to to TO cord-015306-us58wwmp 1598 18 collect collect VB cord-015306-us58wwmp 1598 19 24-hours 24-hours CD cord-015306-us58wwmp 1598 20 - - HYPH cord-015306-us58wwmp 1598 21 urine urine NN cord-015306-us58wwmp 1598 22 , , , cord-015306-us58wwmp 1598 23 blood blood NN cord-015306-us58wwmp 1598 24 , , , cord-015306-us58wwmp 1598 25 kidney kidney NN cord-015306-us58wwmp 1598 26 for for IN cord-015306-us58wwmp 1598 27 detection detection NN cord-015306-us58wwmp 1598 28 . . . cord-015306-us58wwmp 1599 1 Results result NNS cord-015306-us58wwmp 1599 2 : : : cord-015306-us58wwmp 1600 1 All all DT cord-015306-us58wwmp 1600 2 - - HYPH cord-015306-us58wwmp 1600 3 trans trans NNP cord-015306-us58wwmp 1600 4 Retinoic Retinoic NNP cord-015306-us58wwmp 1600 5 Acid Acid NNP cord-015306-us58wwmp 1600 6 significantly significantly RB cord-015306-us58wwmp 1600 7 decreased decrease VBD cord-015306-us58wwmp 1600 8 24-h 24-h JJ cord-015306-us58wwmp 1600 9 urinary urinary JJ cord-015306-us58wwmp 1600 10 protein protein NN cord-015306-us58wwmp 1600 11 excretion excretion NN cord-015306-us58wwmp 1600 12 , , , cord-015306-us58wwmp 1600 13 serum serum NN cord-015306-us58wwmp 1600 14 TC tc NN cord-015306-us58wwmp 1600 15 and and CC cord-015306-us58wwmp 1600 16 TG(P<0.05 TG(P<0.05 NNP cord-015306-us58wwmp 1600 17 ) ) -RRB- cord-015306-us58wwmp 1600 18 . . . cord-015306-us58wwmp 1601 1 Fas Fas NNP cord-015306-us58wwmp 1601 2 / / SYM cord-015306-us58wwmp 1601 3 FasL FasL NNP cord-015306-us58wwmp 1601 4 shows show NNS cord-015306-us58wwmp 1601 5 by by IN cord-015306-us58wwmp 1601 6 Immunohistochemistry Immunohistochemistry NNP cord-015306-us58wwmp 1601 7 and and CC cord-015306-us58wwmp 1601 8 Fluorescence Fluorescence NNP cord-015306-us58wwmp 1601 9 quantitative quantitative JJ cord-015306-us58wwmp 1601 10 PCR pcr NN cord-015306-us58wwmp 1601 11 is be VBZ cord-015306-us58wwmp 1601 12 decreased decrease VBN cord-015306-us58wwmp 1601 13 sifnificantly(P<0.01 sifnificantly(P<0.01 NNP cord-015306-us58wwmp 1601 14 ) ) -RRB- cord-015306-us58wwmp 1601 15 . . . cord-015306-us58wwmp 1602 1 Conclusion conclusion NN cord-015306-us58wwmp 1602 2 : : : cord-015306-us58wwmp 1603 1 All all DT cord-015306-us58wwmp 1603 2 - - HYPH cord-015306-us58wwmp 1603 3 trans trans NNP cord-015306-us58wwmp 1603 4 Retinoic Retinoic NNP cord-015306-us58wwmp 1603 5 Acid Acid NNP cord-015306-us58wwmp 1603 6 has have VBZ cord-015306-us58wwmp 1603 7 anti anti NN cord-015306-us58wwmp 1603 8 - - JJ cord-015306-us58wwmp 1603 9 apoptosis apoptosis JJ cord-015306-us58wwmp 1603 10 on on IN cord-015306-us58wwmp 1603 11 adriamycin adriamycin NNS cord-015306-us58wwmp 1603 12 induced induce VBN cord-015306-us58wwmp 1603 13 nephropathy nephropathy NN cord-015306-us58wwmp 1603 14 mice mouse NNS cord-015306-us58wwmp 1603 15 to to TO cord-015306-us58wwmp 1603 16 protect protect VB cord-015306-us58wwmp 1603 17 kidney kidney NN cord-015306-us58wwmp 1603 18 damage damage NN cord-015306-us58wwmp 1603 19 and and CC cord-015306-us58wwmp 1603 20 delay delay NN cord-015306-us58wwmp 1603 21 fibrosis fibrosis NN cord-015306-us58wwmp 1603 22 process process NN cord-015306-us58wwmp 1603 23 . . . cord-015306-us58wwmp 1604 1 Abstract abstract JJ cord-015306-us58wwmp 1604 2 # # NN cord-015306-us58wwmp 1604 3 P P NNP cord-015306-us58wwmp 1604 4 - - HYPH cord-015306-us58wwmp 1604 5 SAT196 SAT196 NNP cord-015306-us58wwmp 1604 6 Molecular Molecular NNP cord-015306-us58wwmp 1604 7 mechanism mechanism NN cord-015306-us58wwmp 1604 8 of of IN cord-015306-us58wwmp 1604 9 ERS ERS NNP cord-015306-us58wwmp 1604 10 induced induce VBN cord-015306-us58wwmp 1604 11 by by IN cord-015306-us58wwmp 1604 12 lipid lipid NN cord-015306-us58wwmp 1604 13 accumulation accumulation NN cord-015306-us58wwmp 1604 14 in in IN cord-015306-us58wwmp 1604 15 human human JJ cord-015306-us58wwmp 1604 16 mesangial mesangial JJ cord-015306-us58wwmp 1604 17 cells cell NNS cord-015306-us58wwmp 1604 18 ( ( -LRB- cord-015306-us58wwmp 1604 19 HMCs HMCs NNP cord-015306-us58wwmp 1604 20 ) ) -RRB- cord-015306-us58wwmp 1605 1 Objective objective NN cord-015306-us58wwmp 1605 2 : : : cord-015306-us58wwmp 1606 1 Dehydroxymethylepoxyquinomicin Dehydroxymethylepoxyquinomicin NNP cord-015306-us58wwmp 1606 2 ( ( -LRB- cord-015306-us58wwmp 1606 3 DHMEQ DHMEQ NNP cord-015306-us58wwmp 1606 4 ) ) -RRB- cord-015306-us58wwmp 1606 5 is be VBZ cord-015306-us58wwmp 1606 6 a a DT cord-015306-us58wwmp 1606 7 novel novel JJ cord-015306-us58wwmp 1606 8 NF nf NN cord-015306-us58wwmp 1606 9 - - HYPH cord-015306-us58wwmp 1606 10 κB κb CD cord-015306-us58wwmp 1606 11 inhibitor inhibitor NN cord-015306-us58wwmp 1606 12 that that WDT cord-015306-us58wwmp 1606 13 potently potently RB cord-015306-us58wwmp 1606 14 inhibits inhibit VBZ cord-015306-us58wwmp 1606 15 the the DT cord-015306-us58wwmp 1606 16 DNA dna NN cord-015306-us58wwmp 1606 17 - - HYPH cord-015306-us58wwmp 1606 18 binding bind VBG cord-015306-us58wwmp 1606 19 activity activity NN cord-015306-us58wwmp 1606 20 of of IN cord-015306-us58wwmp 1606 21 NF nf NN cord-015306-us58wwmp 1606 22 - - HYPH cord-015306-us58wwmp 1606 23 κB κB NNP cord-015306-us58wwmp 1606 24 , , , cord-015306-us58wwmp 1606 25 resulting result VBG cord-015306-us58wwmp 1606 26 in in IN cord-015306-us58wwmp 1606 27 therapeutic therapeutic JJ cord-015306-us58wwmp 1606 28 effects effect NNS cord-015306-us58wwmp 1606 29 for for IN cord-015306-us58wwmp 1606 30 various various JJ cord-015306-us58wwmp 1606 31 pathological pathological JJ cord-015306-us58wwmp 1606 32 conditions condition NNS cord-015306-us58wwmp 1606 33 . . . cord-015306-us58wwmp 1607 1 To to TO cord-015306-us58wwmp 1607 2 elucidate elucidate VB cord-015306-us58wwmp 1607 3 the the DT cord-015306-us58wwmp 1607 4 pathogenetic pathogenetic JJ cord-015306-us58wwmp 1607 5 role role NN cord-015306-us58wwmp 1607 6 of of IN cord-015306-us58wwmp 1607 7 NF NF NNP cord-015306-us58wwmp 1607 8 - - HYPH cord-015306-us58wwmp 1607 9 κB κB NNP cord-015306-us58wwmp 1607 10 in in IN cord-015306-us58wwmp 1607 11 minimalchange minimalchange NNP cord-015306-us58wwmp 1607 12 nephrotic nephrotic JJ cord-015306-us58wwmp 1607 13 syndrome syndrome NN cord-015306-us58wwmp 1607 14 ( ( -LRB- cord-015306-us58wwmp 1607 15 MCNS MCNS NNP cord-015306-us58wwmp 1607 16 ) ) -RRB- cord-015306-us58wwmp 1607 17 , , , cord-015306-us58wwmp 1607 18 we -PRON- PRP cord-015306-us58wwmp 1607 19 examined examine VBD cord-015306-us58wwmp 1607 20 whether whether IN cord-015306-us58wwmp 1607 21 DHMEQ DHMEQ NNP cord-015306-us58wwmp 1607 22 could could MD cord-015306-us58wwmp 1607 23 ameliorate ameliorate VB cord-015306-us58wwmp 1607 24 the the DT cord-015306-us58wwmp 1607 25 nephrosis nephrosis NN cord-015306-us58wwmp 1607 26 in in IN cord-015306-us58wwmp 1607 27 mice mouse NNS cord-015306-us58wwmp 1607 28 induced induce VBN cord-015306-us58wwmp 1607 29 by by IN cord-015306-us58wwmp 1607 30 puromycin puromycin NNS cord-015306-us58wwmp 1607 31 aminonucleoside aminonucleoside NNP cord-015306-us58wwmp 1607 32 ( ( -LRB- cord-015306-us58wwmp 1607 33 PAN PAN NNP cord-015306-us58wwmp 1607 34 ) ) -RRB- cord-015306-us58wwmp 1607 35 , , , cord-015306-us58wwmp 1607 36 which which WDT cord-015306-us58wwmp 1607 37 is be VBZ cord-015306-us58wwmp 1607 38 considered consider VBN cord-015306-us58wwmp 1607 39 to to TO cord-015306-us58wwmp 1607 40 be be VB cord-015306-us58wwmp 1607 41 an an DT cord-015306-us58wwmp 1607 42 animal animal NN cord-015306-us58wwmp 1607 43 model model NN cord-015306-us58wwmp 1607 44 for for IN cord-015306-us58wwmp 1607 45 MCNS MCNS NNP cord-015306-us58wwmp 1607 46 . . . cord-015306-us58wwmp 1608 1 Methods method NNS cord-015306-us58wwmp 1608 2 : : : cord-015306-us58wwmp 1608 3 Mice mouse NNS cord-015306-us58wwmp 1608 4 were be VBD cord-015306-us58wwmp 1608 5 injected inject VBN cord-015306-us58wwmp 1608 6 with with IN cord-015306-us58wwmp 1608 7 DHMEQ DHMEQ NNP cord-015306-us58wwmp 1608 8 or or CC cord-015306-us58wwmp 1608 9 only only JJ cord-015306-us58wwmp 1608 10 vehicle vehicle NN cord-015306-us58wwmp 1608 11 2 2 CD cord-015306-us58wwmp 1608 12 hours hour NNS cord-015306-us58wwmp 1608 13 before before IN cord-015306-us58wwmp 1608 14 PAN PAN NNP cord-015306-us58wwmp 1608 15 injection injection NN cord-015306-us58wwmp 1608 16 on on IN cord-015306-us58wwmp 1608 17 day day NN cord-015306-us58wwmp 1608 18 0 0 CD cord-015306-us58wwmp 1608 19 . . . cord-015306-us58wwmp 1609 1 Mice mouse NNS cord-015306-us58wwmp 1609 2 without without IN cord-015306-us58wwmp 1609 3 PAN pan NN cord-015306-us58wwmp 1609 4 injection injection NN cord-015306-us58wwmp 1609 5 served serve VBD cord-015306-us58wwmp 1609 6 as as IN cord-015306-us58wwmp 1609 7 controls control NNS cord-015306-us58wwmp 1609 8 . . . cord-015306-us58wwmp 1610 1 The the DT cord-015306-us58wwmp 1610 2 DHMEQ DHMEQ NNP cord-015306-us58wwmp 1610 3 or or CC cord-015306-us58wwmp 1610 4 vehicle vehicle NN cord-015306-us58wwmp 1610 5 was be VBD cord-015306-us58wwmp 1610 6 injected inject VBN cord-015306-us58wwmp 1610 7 on on IN cord-015306-us58wwmp 1610 8 5 5 CD cord-015306-us58wwmp 1610 9 consecutive consecutive JJ cord-015306-us58wwmp 1610 10 days day NNS cord-015306-us58wwmp 1610 11 . . . cord-015306-us58wwmp 1611 1 The the DT cord-015306-us58wwmp 1611 2 daily daily JJ cord-015306-us58wwmp 1611 3 urine urine NN cord-015306-us58wwmp 1611 4 was be VBD cord-015306-us58wwmp 1611 5 collected collect VBN cord-015306-us58wwmp 1611 6 from from IN cord-015306-us58wwmp 1611 7 day day NN cord-015306-us58wwmp 1611 8 0 0 CD cord-015306-us58wwmp 1611 9 to to IN cord-015306-us58wwmp 1611 10 day day NN cord-015306-us58wwmp 1611 11 30 30 CD cord-015306-us58wwmp 1611 12 , , , cord-015306-us58wwmp 1611 13 and and CC cord-015306-us58wwmp 1611 14 the the DT cord-015306-us58wwmp 1611 15 urinary urinary JJ cord-015306-us58wwmp 1611 16 concentrations concentration NNS cord-015306-us58wwmp 1611 17 of of IN cord-015306-us58wwmp 1611 18 albumin albumin NN cord-015306-us58wwmp 1611 19 and and CC cord-015306-us58wwmp 1611 20 creatinine creatinine NN cord-015306-us58wwmp 1611 21 were be VBD cord-015306-us58wwmp 1611 22 measured measure VBN cord-015306-us58wwmp 1611 23 . . . cord-015306-us58wwmp 1612 1 Some some DT cord-015306-us58wwmp 1612 2 mice mouse NNS cord-015306-us58wwmp 1612 3 were be VBD cord-015306-us58wwmp 1612 4 sacrificed sacrifice VBN cord-015306-us58wwmp 1612 5 7 7 CD cord-015306-us58wwmp 1612 6 days day NNS cord-015306-us58wwmp 1612 7 after after IN cord-015306-us58wwmp 1612 8 PAN pan NN cord-015306-us58wwmp 1612 9 - - NN cord-015306-us58wwmp 1612 10 injection injection NN cord-015306-us58wwmp 1612 11 , , , cord-015306-us58wwmp 1612 12 and and CC cord-015306-us58wwmp 1612 13 their -PRON- PRP$ cord-015306-us58wwmp 1612 14 serum serum NN cord-015306-us58wwmp 1612 15 concentrations concentration NNS cord-015306-us58wwmp 1612 16 of of IN cord-015306-us58wwmp 1612 17 cholesterol cholesterol NN cord-015306-us58wwmp 1612 18 , , , cord-015306-us58wwmp 1612 19 total total JJ cord-015306-us58wwmp 1612 20 protein protein NN cord-015306-us58wwmp 1612 21 , , , cord-015306-us58wwmp 1612 22 albumin albumin NN cord-015306-us58wwmp 1612 23 and and CC cord-015306-us58wwmp 1612 24 IL-6 IL-6 NNP cord-015306-us58wwmp 1612 25 were be VBD cord-015306-us58wwmp 1612 26 measured measure VBN cord-015306-us58wwmp 1612 27 and and CC cord-015306-us58wwmp 1612 28 the the DT cord-015306-us58wwmp 1612 29 pathological pathological JJ cord-015306-us58wwmp 1612 30 changes change NNS cord-015306-us58wwmp 1612 31 of of IN cord-015306-us58wwmp 1612 32 the the DT cord-015306-us58wwmp 1612 33 kidneys kidney NNS cord-015306-us58wwmp 1612 34 were be VBD cord-015306-us58wwmp 1612 35 observed observe VBN cord-015306-us58wwmp 1612 36 . . . cord-015306-us58wwmp 1613 1 Results result NNS cord-015306-us58wwmp 1613 2 : : : cord-015306-us58wwmp 1614 1 PAN pan NN cord-015306-us58wwmp 1614 2 injection injection NN cord-015306-us58wwmp 1614 3 without without IN cord-015306-us58wwmp 1614 4 DHMEQ DHMEQ NNP cord-015306-us58wwmp 1614 5 in in IN cord-015306-us58wwmp 1614 6 the the DT cord-015306-us58wwmp 1614 7 mice mouse NNS cord-015306-us58wwmp 1614 8 induced induce VBD cord-015306-us58wwmp 1614 9 albuminuria albuminuria NNS cord-015306-us58wwmp 1614 10 which which WDT cord-015306-us58wwmp 1614 11 gradually gradually RB cord-015306-us58wwmp 1614 12 increased increase VBD cord-015306-us58wwmp 1614 13 up up IN cord-015306-us58wwmp 1614 14 to to IN cord-015306-us58wwmp 1614 15 day day NN cord-015306-us58wwmp 1614 16 10 10 CD cord-015306-us58wwmp 1614 17 and and CC cord-015306-us58wwmp 1614 18 gradually gradually RB cord-015306-us58wwmp 1614 19 decreased decrease VBD cord-015306-us58wwmp 1614 20 thereafter thereafter RB cord-015306-us58wwmp 1614 21 . . . cord-015306-us58wwmp 1615 1 In in IN cord-015306-us58wwmp 1615 2 contrast contrast NN cord-015306-us58wwmp 1615 3 , , , cord-015306-us58wwmp 1615 4 pre pre JJ cord-015306-us58wwmp 1615 5 - - NN cord-015306-us58wwmp 1615 6 treatment treatment NN cord-015306-us58wwmp 1615 7 with with IN cord-015306-us58wwmp 1615 8 DHMEQ DHMEQ NNP cord-015306-us58wwmp 1615 9 was be VBD cord-015306-us58wwmp 1615 10 associated associate VBN cord-015306-us58wwmp 1615 11 with with IN cord-015306-us58wwmp 1615 12 no no DT cord-015306-us58wwmp 1615 13 significant significant JJ cord-015306-us58wwmp 1615 14 increase increase NN cord-015306-us58wwmp 1615 15 in in IN cord-015306-us58wwmp 1615 16 the the DT cord-015306-us58wwmp 1615 17 amount amount NN cord-015306-us58wwmp 1615 18 of of IN cord-015306-us58wwmp 1615 19 albuminuria albuminuria NNS cord-015306-us58wwmp 1615 20 during during IN cord-015306-us58wwmp 1615 21 the the DT cord-015306-us58wwmp 1615 22 first first JJ cord-015306-us58wwmp 1615 23 2 2 CD cord-015306-us58wwmp 1615 24 weeks week NNS cord-015306-us58wwmp 1615 25 . . . cord-015306-us58wwmp 1616 1 In in IN cord-015306-us58wwmp 1616 2 the the DT cord-015306-us58wwmp 1616 3 serological serological JJ cord-015306-us58wwmp 1616 4 tests test NNS cord-015306-us58wwmp 1616 5 , , , cord-015306-us58wwmp 1616 6 PAN pan NN cord-015306-us58wwmp 1616 7 - - NN cord-015306-us58wwmp 1616 8 injection injection NN cord-015306-us58wwmp 1616 9 induced induce VBD cord-015306-us58wwmp 1616 10 an an DT cord-015306-us58wwmp 1616 11 increase increase NN cord-015306-us58wwmp 1616 12 in in IN cord-015306-us58wwmp 1616 13 the the DT cord-015306-us58wwmp 1616 14 cholesterol cholesterol NN cord-015306-us58wwmp 1616 15 level level NN cord-015306-us58wwmp 1616 16 , , , cord-015306-us58wwmp 1616 17 a a DT cord-015306-us58wwmp 1616 18 decrease decrease NN cord-015306-us58wwmp 1616 19 in in IN cord-015306-us58wwmp 1616 20 the the DT cord-015306-us58wwmp 1616 21 total total JJ cord-015306-us58wwmp 1616 22 protein protein NN cord-015306-us58wwmp 1616 23 , , , cord-015306-us58wwmp 1616 24 a a DT cord-015306-us58wwmp 1616 25 decrease decrease NN cord-015306-us58wwmp 1616 26 in in IN cord-015306-us58wwmp 1616 27 the the DT cord-015306-us58wwmp 1616 28 albumin albumin NN cord-015306-us58wwmp 1616 29 and and CC cord-015306-us58wwmp 1616 30 an an DT cord-015306-us58wwmp 1616 31 increase increase NN cord-015306-us58wwmp 1616 32 in in IN cord-015306-us58wwmp 1616 33 the the DT cord-015306-us58wwmp 1616 34 IL-6 IL-6 NNP cord-015306-us58wwmp 1616 35 in in IN cord-015306-us58wwmp 1616 36 the the DT cord-015306-us58wwmp 1616 37 serum serum NN cord-015306-us58wwmp 1616 38 compared compare VBN cord-015306-us58wwmp 1616 39 to to IN cord-015306-us58wwmp 1616 40 controls control NNS cord-015306-us58wwmp 1616 41 7 7 CD cord-015306-us58wwmp 1616 42 days day NNS cord-015306-us58wwmp 1616 43 after after IN cord-015306-us58wwmp 1616 44 injection injection NN cord-015306-us58wwmp 1616 45 , , , cord-015306-us58wwmp 1616 46 but but CC cord-015306-us58wwmp 1616 47 DHMEQ DHMEQ NNP cord-015306-us58wwmp 1616 48 ameliorated ameliorate VBD cord-015306-us58wwmp 1616 49 these these DT cord-015306-us58wwmp 1616 50 changes change NNS cord-015306-us58wwmp 1616 51 . . . cord-015306-us58wwmp 1617 1 An an DT cord-015306-us58wwmp 1617 2 electron electron NN cord-015306-us58wwmp 1617 3 microscopic microscopic JJ cord-015306-us58wwmp 1617 4 analysis analysis NN cord-015306-us58wwmp 1617 5 indicated indicate VBD cord-015306-us58wwmp 1617 6 an an DT cord-015306-us58wwmp 1617 7 effacement effacement NN cord-015306-us58wwmp 1617 8 of of IN cord-015306-us58wwmp 1617 9 the the DT cord-015306-us58wwmp 1617 10 foot foot NN cord-015306-us58wwmp 1617 11 processes process NNS cord-015306-us58wwmp 1617 12 of of IN cord-015306-us58wwmp 1617 13 the the DT cord-015306-us58wwmp 1617 14 podocytes podocyte NNS cord-015306-us58wwmp 1617 15 in in IN cord-015306-us58wwmp 1617 16 the the DT cord-015306-us58wwmp 1617 17 PAN PAN NNP cord-015306-us58wwmp 1617 18 - - HYPH cord-015306-us58wwmp 1617 19 injected inject VBN cord-015306-us58wwmp 1617 20 mice mouse NNS cord-015306-us58wwmp 1617 21 , , , cord-015306-us58wwmp 1617 22 but but CC cord-015306-us58wwmp 1617 23 this this DT cord-015306-us58wwmp 1617 24 was be VBD cord-015306-us58wwmp 1617 25 rarely rarely RB cord-015306-us58wwmp 1617 26 observed observe VBN cord-015306-us58wwmp 1617 27 in in IN cord-015306-us58wwmp 1617 28 the the DT cord-015306-us58wwmp 1617 29 PAN pan NN cord-015306-us58wwmp 1617 30 - - HYPH cord-015306-us58wwmp 1617 31 injected inject VBN cord-015306-us58wwmp 1617 32 mice mouse NNS cord-015306-us58wwmp 1617 33 pre pre VBN cord-015306-us58wwmp 1617 34 - - VBN cord-015306-us58wwmp 1617 35 treated treat VBN cord-015306-us58wwmp 1617 36 with with IN cord-015306-us58wwmp 1617 37 DHMEQ DHMEQ NNP cord-015306-us58wwmp 1617 38 . . . cord-015306-us58wwmp 1618 1 Further further JJ cord-015306-us58wwmp 1618 2 immunohistochemical immunohistochemical JJ cord-015306-us58wwmp 1618 3 analysis analysis NN cord-015306-us58wwmp 1618 4 showed show VBD cord-015306-us58wwmp 1618 5 that that IN cord-015306-us58wwmp 1618 6 DHMEQ DHMEQ NNP cord-015306-us58wwmp 1618 7 can can MD cord-015306-us58wwmp 1618 8 inhibit inhibit VB cord-015306-us58wwmp 1618 9 the the DT cord-015306-us58wwmp 1618 10 PAN pan NN cord-015306-us58wwmp 1618 11 - - HYPH cord-015306-us58wwmp 1618 12 induced induce VBN cord-015306-us58wwmp 1618 13 translocation translocation NN cord-015306-us58wwmp 1618 14 of of IN cord-015306-us58wwmp 1618 15 NF nf NN cord-015306-us58wwmp 1618 16 - - HYPH cord-015306-us58wwmp 1618 17 κB κB NNP cord-015306-us58wwmp 1618 18 from from IN cord-015306-us58wwmp 1618 19 cytoplasm cytoplasm NN cord-015306-us58wwmp 1618 20 into into IN cord-015306-us58wwmp 1618 21 nucleus nucleus NN cord-015306-us58wwmp 1618 22 . . . cord-015306-us58wwmp 1619 1 Conclusion conclusion NN cord-015306-us58wwmp 1619 2 : : : cord-015306-us58wwmp 1620 1 These these DT cord-015306-us58wwmp 1620 2 results result NNS cord-015306-us58wwmp 1620 3 suggest suggest VBP cord-015306-us58wwmp 1620 4 that that IN cord-015306-us58wwmp 1620 5 DHMEQ DHMEQ NNP cord-015306-us58wwmp 1620 6 can can MD cord-015306-us58wwmp 1620 7 be be VB cord-015306-us58wwmp 1620 8 a a DT cord-015306-us58wwmp 1620 9 candidate candidate NN cord-015306-us58wwmp 1620 10 therapeutic therapeutic JJ cord-015306-us58wwmp 1620 11 agent agent NN cord-015306-us58wwmp 1620 12 for for IN cord-015306-us58wwmp 1620 13 MCNS MCNS NNP cord-015306-us58wwmp 1620 14 , , , cord-015306-us58wwmp 1620 15 because because IN cord-015306-us58wwmp 1620 16 the the DT cord-015306-us58wwmp 1620 17 activation activation NN cord-015306-us58wwmp 1620 18 of of IN cord-015306-us58wwmp 1620 19 NF nf NN cord-015306-us58wwmp 1620 20 - - HYPH cord-015306-us58wwmp 1620 21 κB κB NNP cord-015306-us58wwmp 1620 22 of of IN cord-015306-us58wwmp 1620 23 podocytes podocyte NNS cord-015306-us58wwmp 1620 24 may may MD cord-015306-us58wwmp 1620 25 be be VB cord-015306-us58wwmp 1620 26 associated associate VBN cord-015306-us58wwmp 1620 27 with with IN cord-015306-us58wwmp 1620 28 PAN pan NN cord-015306-us58wwmp 1620 29 - - HYPH cord-015306-us58wwmp 1620 30 induced induce VBN cord-015306-us58wwmp 1620 31 nephrosis nephrosis NN cord-015306-us58wwmp 1620 32 . . . cord-015306-us58wwmp 1621 1 Knocking knock VBG cord-015306-us58wwmp 1621 2 - - HYPH cord-015306-us58wwmp 1621 3 down down RP cord-015306-us58wwmp 1621 4 STIM1 stim1 JJ cord-015306-us58wwmp 1621 5 gene gene NN cord-015306-us58wwmp 1621 6 expression expression NN cord-015306-us58wwmp 1621 7 inhibits inhibit VBZ cord-015306-us58wwmp 1621 8 some some DT cord-015306-us58wwmp 1621 9 podocyte podocyte NNP cord-015306-us58wwmp 1621 10 molecules molecules NNP cord-015306-us58wwmp 1621 11 jingjing jingjing NNP cord-015306-us58wwmp 1621 12 yan yan NNP cord-015306-us58wwmp 1621 13 , , , cord-015306-us58wwmp 1621 14 meigui meigui NNP cord-015306-us58wwmp 1621 15 wang wang NNP cord-015306-us58wwmp 1621 16 , , , cord-015306-us58wwmp 1621 17 siguang siguang NNP cord-015306-us58wwmp 1621 18 lu lu NNP cord-015306-us58wwmp 1622 1 The the DT cord-015306-us58wwmp 1622 2 First First NNP cord-015306-us58wwmp 1622 3 People People NNPS cord-015306-us58wwmp 1622 4 's 's POS cord-015306-us58wwmp 1622 5 Hospital Hospital NNP cord-015306-us58wwmp 1622 6 , , , cord-015306-us58wwmp 1622 7 Lianyungang Lianyungang NNP cord-015306-us58wwmp 1622 8 , , , cord-015306-us58wwmp 1622 9 Jiangsu Jiangsu NNP cord-015306-us58wwmp 1622 10 , , , cord-015306-us58wwmp 1622 11 China China NNP cord-015306-us58wwmp 1622 12 Objective Objective NNP cord-015306-us58wwmp 1622 13 : : : cord-015306-us58wwmp 1623 1 To to TO cord-015306-us58wwmp 1623 2 study study VB cord-015306-us58wwmp 1623 3 the the DT cord-015306-us58wwmp 1623 4 effect effect NN cord-015306-us58wwmp 1623 5 of of IN cord-015306-us58wwmp 1623 6 knocking knock VBG cord-015306-us58wwmp 1623 7 - - HYPH cord-015306-us58wwmp 1623 8 down down RP cord-015306-us58wwmp 1623 9 STIM1 stim1 NN cord-015306-us58wwmp 1623 10 on on IN cord-015306-us58wwmp 1623 11 nephrin nephrin NNP cord-015306-us58wwmp 1623 12 , , , cord-015306-us58wwmp 1623 13 podocin podocin NNP cord-015306-us58wwmp 1623 14 , , , cord-015306-us58wwmp 1623 15 CD-2AP CD-2AP NNP cord-015306-us58wwmp 1623 16 and and CC cord-015306-us58wwmp 1623 17 α α NNP cord-015306-us58wwmp 1623 18 - - : cord-015306-us58wwmp 1623 19 actinin-4 actinin-4 NNP cord-015306-us58wwmp 1623 20 in in IN cord-015306-us58wwmp 1623 21 murine murine JJ cord-015306-us58wwmp 1623 22 podocytes podocyte NNS cord-015306-us58wwmp 1623 23 in in IN cord-015306-us58wwmp 1623 24 vitro vitro FW cord-015306-us58wwmp 1623 25 . . . cord-015306-us58wwmp 1624 1 Methods method NNS cord-015306-us58wwmp 1624 2 : : : cord-015306-us58wwmp 1624 3 Conditionally conditionally RB cord-015306-us58wwmp 1624 4 immortalized immortalize VBN cord-015306-us58wwmp 1624 5 murine murine JJ cord-015306-us58wwmp 1624 6 podocyte podocyte NNP cord-015306-us58wwmp 1624 7 cells cell NNS cord-015306-us58wwmp 1624 8 were be VBD cord-015306-us58wwmp 1624 9 cultured culture VBN cord-015306-us58wwmp 1624 10 in in IN cord-015306-us58wwmp 1624 11 RPMI1640 rpmi1640 JJ cord-015306-us58wwmp 1624 12 medium medium NN cord-015306-us58wwmp 1624 13 at at IN cord-015306-us58wwmp 1624 14 33 33 CD cord-015306-us58wwmp 1624 15 ° ° NN cord-015306-us58wwmp 1624 16 C C NNP cord-015306-us58wwmp 1624 17 permissive permissive JJ cord-015306-us58wwmp 1624 18 condition condition NN cord-015306-us58wwmp 1624 19 . . . cord-015306-us58wwmp 1625 1 Then then RB cord-015306-us58wwmp 1625 2 the the DT cord-015306-us58wwmp 1625 3 cells cell NNS cord-015306-us58wwmp 1625 4 were be VBD cord-015306-us58wwmp 1625 5 shifted shift VBN cord-015306-us58wwmp 1625 6 to to IN cord-015306-us58wwmp 1625 7 non non JJ cord-015306-us58wwmp 1625 8 - - JJ cord-015306-us58wwmp 1625 9 permissive permissive JJ cord-015306-us58wwmp 1625 10 condition condition NN cord-015306-us58wwmp 1625 11 at37 at37 NNP cord-015306-us58wwmp 1625 12 ° ° NNP cord-015306-us58wwmp 1625 13 C C NNP cord-015306-us58wwmp 1625 14 and and CC cord-015306-us58wwmp 1625 15 cultured culture VBN cord-015306-us58wwmp 1625 16 for for IN cord-015306-us58wwmp 1625 17 ten ten CD cord-015306-us58wwmp 1625 18 - - HYPH cord-015306-us58wwmp 1625 19 fourteen fourteen CD cord-015306-us58wwmp 1625 20 days day NNS cord-015306-us58wwmp 1625 21 , , , cord-015306-us58wwmp 1625 22 and and CC cord-015306-us58wwmp 1625 23 were be VBD cord-015306-us58wwmp 1625 24 transfected transfecte VBN cord-015306-us58wwmp 1625 25 with with IN cord-015306-us58wwmp 1625 26 STIM1 stim1 JJ cord-015306-us58wwmp 1625 27 small small JJ cord-015306-us58wwmp 1625 28 interfering interfere VBG cord-015306-us58wwmp 1625 29 RNA(siRNA RNA(siRNA '' cord-015306-us58wwmp 1625 30 ) ) -RRB- cord-015306-us58wwmp 1625 31 using use VBG cord-015306-us58wwmp 1625 32 transfection transfection NN cord-015306-us58wwmp 1625 33 reagent reagent NNP cord-015306-us58wwmp 1625 34 lipofectamine lipofectamine NNP cord-015306-us58wwmp 1625 35 2000.Transfection 2000.transfection CD cord-015306-us58wwmp 1625 36 efficiency efficiency NN cord-015306-us58wwmp 1625 37 was be VBD cord-015306-us58wwmp 1625 38 measured measure VBN cord-015306-us58wwmp 1625 39 by by IN cord-015306-us58wwmp 1625 40 flow flow NN cord-015306-us58wwmp 1625 41 cytometer cytometer NN cord-015306-us58wwmp 1625 42 and and CC cord-015306-us58wwmp 1625 43 inhibitory inhibitory JJ cord-015306-us58wwmp 1625 44 effect effect NN cord-015306-us58wwmp 1625 45 of of IN cord-015306-us58wwmp 1625 46 STIM1 STIM1 NNP cord-015306-us58wwmp 1625 47 siRNA siRNA NNP cord-015306-us58wwmp 1625 48 was be VBD cord-015306-us58wwmp 1625 49 determined determine VBN cord-015306-us58wwmp 1625 50 by by IN cord-015306-us58wwmp 1625 51 RT RT NNP cord-015306-us58wwmp 1625 52 - - HYPH cord-015306-us58wwmp 1625 53 PCR PCR NNP cord-015306-us58wwmp 1625 54 and and CC cord-015306-us58wwmp 1625 55 western western JJ cord-015306-us58wwmp 1625 56 blot blot NN cord-015306-us58wwmp 1625 57 at at IN cord-015306-us58wwmp 1625 58 fourty fourty CD cord-015306-us58wwmp 1625 59 - - HYPH cord-015306-us58wwmp 1625 60 eight eight CD cord-015306-us58wwmp 1625 61 , , , cord-015306-us58wwmp 1625 62 senventy senventy NN cord-015306-us58wwmp 1625 63 - - HYPH cord-015306-us58wwmp 1625 64 two two CD cord-015306-us58wwmp 1625 65 hours hour NNS cord-015306-us58wwmp 1625 66 after after IN cord-015306-us58wwmp 1625 67 transfection transfection NN cord-015306-us58wwmp 1625 68 respectively respectively RB cord-015306-us58wwmp 1625 69 . . . cord-015306-us58wwmp 1626 1 Results result NNS cord-015306-us58wwmp 1626 2 : : : cord-015306-us58wwmp 1626 3 ( ( -LRB- cord-015306-us58wwmp 1627 1 1)The 1)the CD cord-015306-us58wwmp 1627 2 transfection transfection NN cord-015306-us58wwmp 1627 3 efficiency efficiency NN cord-015306-us58wwmp 1627 4 of of IN cord-015306-us58wwmp 1627 5 FAM FAM NNP cord-015306-us58wwmp 1627 6 - - HYPH cord-015306-us58wwmp 1627 7 siRNA siRNA NNP cord-015306-us58wwmp 1627 8 was be VBD cord-015306-us58wwmp 1627 9 about about RB cord-015306-us58wwmp 1627 10 75.5 75.5 CD cord-015306-us58wwmp 1627 11 % % NN cord-015306-us58wwmp 1627 12 . . . cord-015306-us58wwmp 1628 1 ( ( -LRB- cord-015306-us58wwmp 1628 2 2)After 2)after CD cord-015306-us58wwmp 1628 3 transfection transfection NN cord-015306-us58wwmp 1628 4 with with IN cord-015306-us58wwmp 1628 5 specific specific JJ cord-015306-us58wwmp 1628 6 siRNA siRNA NNP cord-015306-us58wwmp 1628 7 , , , cord-015306-us58wwmp 1628 8 the the DT cord-015306-us58wwmp 1628 9 expression expression NN cord-015306-us58wwmp 1628 10 levels level NNS cord-015306-us58wwmp 1628 11 of of IN cord-015306-us58wwmp 1628 12 STIM1 STIM1 NNP cord-015306-us58wwmp 1628 13 mRNA mRNA NNP cord-015306-us58wwmp 1628 14 and and CC cord-015306-us58wwmp 1628 15 protein protein NN cord-015306-us58wwmp 1628 16 were be VBD cord-015306-us58wwmp 1628 17 down down RB cord-015306-us58wwmp 1628 18 - - HYPH cord-015306-us58wwmp 1628 19 regulated regulate VBN cord-015306-us58wwmp 1628 20 by by IN cord-015306-us58wwmp 1628 21 80.7 80.7 CD cord-015306-us58wwmp 1628 22 % % NN cord-015306-us58wwmp 1628 23 and and CC cord-015306-us58wwmp 1628 24 49.8 49.8 CD cord-015306-us58wwmp 1628 25 % % NN cord-015306-us58wwmp 1628 26 respectively respectively RB cord-015306-us58wwmp 1628 27 . . . cord-015306-us58wwmp 1629 1 ( ( -LRB- cord-015306-us58wwmp 1629 2 3 3 LS cord-015306-us58wwmp 1629 3 ) ) -RRB- cord-015306-us58wwmp 1630 1 The the DT cord-015306-us58wwmp 1630 2 expression expression NN cord-015306-us58wwmp 1630 3 levels level NNS cord-015306-us58wwmp 1630 4 of of IN cord-015306-us58wwmp 1630 5 nephrin nephrin NNP cord-015306-us58wwmp 1630 6 , , , cord-015306-us58wwmp 1630 7 podocin podocin NNP cord-015306-us58wwmp 1630 8 and and CC cord-015306-us58wwmp 1630 9 α α NN cord-015306-us58wwmp 1630 10 - - HYPH cord-015306-us58wwmp 1630 11 actinin-4 actinin-4 NNP cord-015306-us58wwmp 1630 12 mRNA mrna NN cord-015306-us58wwmp 1630 13 were be VBD cord-015306-us58wwmp 1630 14 decreased decrease VBN cord-015306-us58wwmp 1630 15 by by IN cord-015306-us58wwmp 1630 16 62 62 CD cord-015306-us58wwmp 1630 17 % % NN cord-015306-us58wwmp 1630 18 , , , cord-015306-us58wwmp 1630 19 35 35 CD cord-015306-us58wwmp 1630 20 % % NN cord-015306-us58wwmp 1630 21 , , , cord-015306-us58wwmp 1630 22 60 60 CD cord-015306-us58wwmp 1630 23 % % NN cord-015306-us58wwmp 1630 24 respectively respectively RB cord-015306-us58wwmp 1630 25 , , , cord-015306-us58wwmp 1630 26 whereas whereas IN cord-015306-us58wwmp 1630 27 CD-2AP CD-2AP NNP cord-015306-us58wwmp 1630 28 showed show VBD cord-015306-us58wwmp 1630 29 no no DT cord-015306-us58wwmp 1630 30 - - HYPH cord-015306-us58wwmp 1630 31 change change NN cord-015306-us58wwmp 1630 32 . . . cord-015306-us58wwmp 1631 1 Both both DT cord-015306-us58wwmp 1631 2 podocin podocin NNS cord-015306-us58wwmp 1631 3 and and CC cord-015306-us58wwmp 1631 4 α α NN cord-015306-us58wwmp 1631 5 - - HYPH cord-015306-us58wwmp 1631 6 actinin-4 actinin-4 NNP cord-015306-us58wwmp 1631 7 protein protein NN cord-015306-us58wwmp 1631 8 were be VBD cord-015306-us58wwmp 1631 9 decreased decrease VBN cord-015306-us58wwmp 1631 10 by by IN cord-015306-us58wwmp 1631 11 45 45 CD cord-015306-us58wwmp 1631 12 % % NN cord-015306-us58wwmp 1631 13 , , , cord-015306-us58wwmp 1631 14 20 20 CD cord-015306-us58wwmp 1631 15 % % NN cord-015306-us58wwmp 1631 16 respectively respectively RB cord-015306-us58wwmp 1631 17 . . . cord-015306-us58wwmp 1632 1 Objective objective NN cord-015306-us58wwmp 1632 2 : : : cord-015306-us58wwmp 1633 1 One one CD cord-015306-us58wwmp 1633 2 of of IN cord-015306-us58wwmp 1633 3 the the DT cord-015306-us58wwmp 1633 4 most most RBS cord-015306-us58wwmp 1633 5 common common JJ cord-015306-us58wwmp 1633 6 causes cause NNS cord-015306-us58wwmp 1633 7 of of IN cord-015306-us58wwmp 1633 8 nephrotic nephrotic JJ cord-015306-us58wwmp 1633 9 syndromes syndrome NNS cord-015306-us58wwmp 1633 10 in in IN cord-015306-us58wwmp 1633 11 children child NNS cord-015306-us58wwmp 1633 12 is be VBZ cord-015306-us58wwmp 1633 13 the the DT cord-015306-us58wwmp 1633 14 Minimal minimal JJ cord-015306-us58wwmp 1633 15 - - HYPH cord-015306-us58wwmp 1633 16 Change change NN cord-015306-us58wwmp 1633 17 - - HYPH cord-015306-us58wwmp 1633 18 Glomerulonephritis Glomerulonephritis NNP cord-015306-us58wwmp 1633 19 ( ( -LRB- cord-015306-us58wwmp 1633 20 MCGN MCGN NNP cord-015306-us58wwmp 1633 21 ) ) -RRB- cord-015306-us58wwmp 1633 22 . . . cord-015306-us58wwmp 1634 1 Typically typically RB cord-015306-us58wwmp 1634 2 , , , cord-015306-us58wwmp 1634 3 MCGN MCGN NNP cord-015306-us58wwmp 1634 4 results result NNS cord-015306-us58wwmp 1634 5 in in IN cord-015306-us58wwmp 1634 6 foot foot NN cord-015306-us58wwmp 1634 7 processes process NNS cord-015306-us58wwmp 1634 8 effacement effacement NN cord-015306-us58wwmp 1634 9 of of IN cord-015306-us58wwmp 1634 10 podocytes podocyte NNS cord-015306-us58wwmp 1634 11 . . . cord-015306-us58wwmp 1635 1 Their -PRON- PRP$ cord-015306-us58wwmp 1635 2 plate plate NN cord-015306-us58wwmp 1635 3 - - HYPH cord-015306-us58wwmp 1635 4 shaped shape VBN cord-015306-us58wwmp 1635 5 flattening flatten VBG cord-015306-us58wwmp 1635 6 very very RB cord-015306-us58wwmp 1635 7 likely likely JJ cord-015306-us58wwmp 1635 8 results result NNS cord-015306-us58wwmp 1635 9 in in IN cord-015306-us58wwmp 1635 10 dysfunction dysfunction NN cord-015306-us58wwmp 1635 11 of of IN cord-015306-us58wwmp 1635 12 the the DT cord-015306-us58wwmp 1635 13 filtration filtration NN cord-015306-us58wwmp 1635 14 barrier barrier NN cord-015306-us58wwmp 1635 15 and and CC cord-015306-us58wwmp 1635 16 may may MD cord-015306-us58wwmp 1635 17 underlie underlie VB cord-015306-us58wwmp 1635 18 the the DT cord-015306-us58wwmp 1635 19 increase increase NN cord-015306-us58wwmp 1635 20 in in IN cord-015306-us58wwmp 1635 21 urine urine NN cord-015306-us58wwmp 1635 22 albumin albumin NN cord-015306-us58wwmp 1635 23 concentrations concentration NNS cord-015306-us58wwmp 1635 24 . . . cord-015306-us58wwmp 1636 1 Notably notably RB cord-015306-us58wwmp 1636 2 , , , cord-015306-us58wwmp 1636 3 MCGN MCGN NNP cord-015306-us58wwmp 1636 4 often often RB cord-015306-us58wwmp 1636 5 disappears disappear VBZ cord-015306-us58wwmp 1636 6 at at IN cord-015306-us58wwmp 1636 7 the the DT cord-015306-us58wwmp 1636 8 onset onset NN cord-015306-us58wwmp 1636 9 of of IN cord-015306-us58wwmp 1636 10 puberty puberty NN cord-015306-us58wwmp 1636 11 , , , cord-015306-us58wwmp 1636 12 thus thus RB cord-015306-us58wwmp 1636 13 in in IN cord-015306-us58wwmp 1636 14 parallel parallel NN cord-015306-us58wwmp 1636 15 with with IN cord-015306-us58wwmp 1636 16 increasing increase VBG cord-015306-us58wwmp 1636 17 peripheral peripheral JJ cord-015306-us58wwmp 1636 18 hormone hormone NN cord-015306-us58wwmp 1636 19 levels level NNS cord-015306-us58wwmp 1636 20 . . . cord-015306-us58wwmp 1637 1 This this DT cord-015306-us58wwmp 1637 2 is be VBZ cord-015306-us58wwmp 1637 3 particularly particularly RB cord-015306-us58wwmp 1637 4 true true JJ cord-015306-us58wwmp 1637 5 in in IN cord-015306-us58wwmp 1637 6 girls girl NNS cord-015306-us58wwmp 1637 7 . . . cord-015306-us58wwmp 1638 1 Methods method NNS cord-015306-us58wwmp 1638 2 : : : cord-015306-us58wwmp 1639 1 Podocytes Podocytes NNP cord-015306-us58wwmp 1639 2 were be VBD cord-015306-us58wwmp 1639 3 studied study VBN cord-015306-us58wwmp 1639 4 by by IN cord-015306-us58wwmp 1639 5 Western Western NNP cord-015306-us58wwmp 1639 6 Blot Blot NNP cord-015306-us58wwmp 1639 7 analysis analysis NN cord-015306-us58wwmp 1639 8 , , , cord-015306-us58wwmp 1639 9 Immunofluorescence Immunofluorescence NNP cord-015306-us58wwmp 1639 10 and and CC cord-015306-us58wwmp 1639 11 by by IN cord-015306-us58wwmp 1639 12 radioimmunoassay radioimmunoassay JJ cord-015306-us58wwmp 1639 13 for for IN cord-015306-us58wwmp 1639 14 their -PRON- PRP$ cord-015306-us58wwmp 1639 15 ability ability NN cord-015306-us58wwmp 1639 16 to to TO cord-015306-us58wwmp 1639 17 secrete secrete VB cord-015306-us58wwmp 1639 18 and and CC cord-015306-us58wwmp 1639 19 bind bind VB cord-015306-us58wwmp 1639 20 estrogens estrogen NNS cord-015306-us58wwmp 1639 21 . . . cord-015306-us58wwmp 1640 1 Results result NNS cord-015306-us58wwmp 1640 2 : : : cord-015306-us58wwmp 1641 1 Podocytes Podocytes NNP cord-015306-us58wwmp 1641 2 express express VBP cord-015306-us58wwmp 1641 3 estrogen estrogen NN cord-015306-us58wwmp 1641 4 receptors receptor NNS cord-015306-us58wwmp 1641 5 both both DT cord-015306-us58wwmp 1641 6 , , , cord-015306-us58wwmp 1641 7 estrogen estrogen NN cord-015306-us58wwmp 1641 8 receptor receptor NN cord-015306-us58wwmp 1641 9 alpha alpha NN cord-015306-us58wwmp 1641 10 and and CC cord-015306-us58wwmp 1641 11 beta beta NN cord-015306-us58wwmp 1641 12 , , , cord-015306-us58wwmp 1641 13 suggesting suggest VBG cord-015306-us58wwmp 1641 14 that that IN cord-015306-us58wwmp 1641 15 increasing increase VBG cord-015306-us58wwmp 1641 16 levels level NNS cord-015306-us58wwmp 1641 17 of of IN cord-015306-us58wwmp 1641 18 estradiol estradiol NN cord-015306-us58wwmp 1641 19 during during IN cord-015306-us58wwmp 1641 20 puberty puberty NN cord-015306-us58wwmp 1641 21 potentially potentially RB cord-015306-us58wwmp 1641 22 maintains maintain VBZ cord-015306-us58wwmp 1641 23 and and CC cord-015306-us58wwmp 1641 24 restores restore VBZ cord-015306-us58wwmp 1641 25 morphological morphological JJ cord-015306-us58wwmp 1641 26 integrity integrity NN cord-015306-us58wwmp 1641 27 of of IN cord-015306-us58wwmp 1641 28 podocytes podocyte NNS cord-015306-us58wwmp 1641 29 . . . cord-015306-us58wwmp 1642 1 This this DT cord-015306-us58wwmp 1642 2 protective protective JJ cord-015306-us58wwmp 1642 3 function function NN cord-015306-us58wwmp 1642 4 could could MD cord-015306-us58wwmp 1642 5 be be VB cord-015306-us58wwmp 1642 6 mediated mediate VBN cord-015306-us58wwmp 1642 7 by by IN cord-015306-us58wwmp 1642 8 stabilization stabilization NN cord-015306-us58wwmp 1642 9 of of IN cord-015306-us58wwmp 1642 10 the the DT cord-015306-us58wwmp 1642 11 podocyte podocyte NNP cord-015306-us58wwmp 1642 12 cytoskeleton cytoskeleton NNP cord-015306-us58wwmp 1642 13 by by IN cord-015306-us58wwmp 1642 14 estradiol estradiol NN cord-015306-us58wwmp 1642 15 , , , cord-015306-us58wwmp 1642 16 as as IN cord-015306-us58wwmp 1642 17 evidenced evidence VBN cord-015306-us58wwmp 1642 18 in in IN cord-015306-us58wwmp 1642 19 vitro vitro FW cord-015306-us58wwmp 1642 20 by by IN cord-015306-us58wwmp 1642 21 the the DT cord-015306-us58wwmp 1642 22 increase increase NN cord-015306-us58wwmp 1642 23 in in IN cord-015306-us58wwmp 1642 24 phosphorylation phosphorylation NN cord-015306-us58wwmp 1642 25 of of IN cord-015306-us58wwmp 1642 26 cofilin cofilin NN cord-015306-us58wwmp 1642 27 , , , cord-015306-us58wwmp 1642 28 very very RB cord-015306-us58wwmp 1642 29 similar similar JJ cord-015306-us58wwmp 1642 30 to to IN cord-015306-us58wwmp 1642 31 the the DT cord-015306-us58wwmp 1642 32 effects effect NNS cord-015306-us58wwmp 1642 33 of of IN cord-015306-us58wwmp 1642 34 estradiol estradiol NN cord-015306-us58wwmp 1642 35 in in IN cord-015306-us58wwmp 1642 36 neurons neuron NNS cord-015306-us58wwmp 1642 37 . . . cord-015306-us58wwmp 1643 1 Furthermore furthermore RB cord-015306-us58wwmp 1643 2 , , , cord-015306-us58wwmp 1643 3 we -PRON- PRP cord-015306-us58wwmp 1643 4 show show VBP cord-015306-us58wwmp 1643 5 that that IN cord-015306-us58wwmp 1643 6 dissociated dissociate VBN cord-015306-us58wwmp 1643 7 podocytes podocytes NNP cord-015306-us58wwmp 1643 8 express express NNP cord-015306-us58wwmp 1643 9 aromatase aromatase NNP cord-015306-us58wwmp 1643 10 , , , cord-015306-us58wwmp 1643 11 the the DT cord-015306-us58wwmp 1643 12 final final JJ cord-015306-us58wwmp 1643 13 enzyme enzyme NN cord-015306-us58wwmp 1643 14 of of IN cord-015306-us58wwmp 1643 15 estrogen estrogen NN cord-015306-us58wwmp 1643 16 synthesis synthesis NN cord-015306-us58wwmp 1643 17 , , , cord-015306-us58wwmp 1643 18 and and CC cord-015306-us58wwmp 1643 19 that that IN cord-015306-us58wwmp 1643 20 podocytes podocytes NNP cord-015306-us58wwmp 1643 21 in in IN cord-015306-us58wwmp 1643 22 fact fact NN cord-015306-us58wwmp 1643 23 synthesize synthesize VB cord-015306-us58wwmp 1643 24 estradiol estradiol NN cord-015306-us58wwmp 1643 25 , , , cord-015306-us58wwmp 1643 26 as as IN cord-015306-us58wwmp 1643 27 evidenced evidence VBN cord-015306-us58wwmp 1643 28 by by IN cord-015306-us58wwmp 1643 29 measuring measure VBG cord-015306-us58wwmp 1643 30 estradiol estradiol NN cord-015306-us58wwmp 1643 31 content content NN cord-015306-us58wwmp 1643 32 in in IN cord-015306-us58wwmp 1643 33 the the DT cord-015306-us58wwmp 1643 34 supernatant supernatant NN cord-015306-us58wwmp 1643 35 . . . cord-015306-us58wwmp 1644 1 Conclusion conclusion NN cord-015306-us58wwmp 1644 2 : : : cord-015306-us58wwmp 1645 1 As as IN cord-015306-us58wwmp 1645 2 it -PRON- PRP cord-015306-us58wwmp 1645 3 was be VBD cord-015306-us58wwmp 1645 4 shown show VBN cord-015306-us58wwmp 1645 5 that that IN cord-015306-us58wwmp 1645 6 estrogen estrogen NN cord-015306-us58wwmp 1645 7 synthesis synthesis NN cord-015306-us58wwmp 1645 8 in in IN cord-015306-us58wwmp 1645 9 cells cell NNS cord-015306-us58wwmp 1645 10 other other JJ cord-015306-us58wwmp 1645 11 than than IN cord-015306-us58wwmp 1645 12 those those DT cord-015306-us58wwmp 1645 13 in in IN cord-015306-us58wwmp 1645 14 gonads gonad NNS cord-015306-us58wwmp 1645 15 becomes become VBZ cord-015306-us58wwmp 1645 16 stimulated stimulate VBN cord-015306-us58wwmp 1645 17 during during IN cord-015306-us58wwmp 1645 18 puberty puberty NN cord-015306-us58wwmp 1645 19 , , , cord-015306-us58wwmp 1645 20 an an DT cord-015306-us58wwmp 1645 21 autocrine autocrine JJ cord-015306-us58wwmp 1645 22 mechanism mechanism NN cord-015306-us58wwmp 1645 23 of of IN cord-015306-us58wwmp 1645 24 estrogen estrogen NN cord-015306-us58wwmp 1645 25 action action NN cord-015306-us58wwmp 1645 26 could could MD cord-015306-us58wwmp 1645 27 underlie underlie VB cord-015306-us58wwmp 1645 28 decreasing decrease VBG cord-015306-us58wwmp 1645 29 frequency frequency NN cord-015306-us58wwmp 1645 30 of of IN cord-015306-us58wwmp 1645 31 MCGN MCGN NNS cord-015306-us58wwmp 1645 32 at at IN cord-015306-us58wwmp 1645 33 the the DT cord-015306-us58wwmp 1645 34 onset onset NN cord-015306-us58wwmp 1645 35 of of IN cord-015306-us58wwmp 1645 36 puberty puberty NN cord-015306-us58wwmp 1645 37 . . . cord-015306-us58wwmp 1646 1 Overexpression Overexpression NNP cord-015306-us58wwmp 1646 2 of of IN cord-015306-us58wwmp 1646 3 PGC-1α PGC-1α NNP cord-015306-us58wwmp 1646 4 inhibits inhibit VBZ cord-015306-us58wwmp 1646 5 aldosterone aldosterone NN cord-015306-us58wwmp 1646 6 - - HYPH cord-015306-us58wwmp 1646 7 induced induce VBN cord-015306-us58wwmp 1646 8 podocyte podocyte NNP cord-015306-us58wwmp 1646 9 phenotypic phenotypic JJ cord-015306-us58wwmp 1646 10 changes change NNS cord-015306-us58wwmp 1646 11 and and CC cord-015306-us58wwmp 1646 12 detachment detachment NN cord-015306-us58wwmp 1646 13 by by IN cord-015306-us58wwmp 1646 14 blocking block VBG cord-015306-us58wwmp 1646 15 mitochondrial mitochondrial JJ cord-015306-us58wwmp 1646 16 dysfunction dysfunction NN cord-015306-us58wwmp 1646 17 Objective objective NN cord-015306-us58wwmp 1646 18 : : : cord-015306-us58wwmp 1647 1 To to TO cord-015306-us58wwmp 1647 2 explore explore VB cord-015306-us58wwmp 1647 3 the the DT cord-015306-us58wwmp 1647 4 role role NN cord-015306-us58wwmp 1647 5 of of IN cord-015306-us58wwmp 1647 6 heparanase heparanase NNP cord-015306-us58wwmp 1647 7 in in IN cord-015306-us58wwmp 1647 8 the the DT cord-015306-us58wwmp 1647 9 pathogenesis pathogenesis NN cord-015306-us58wwmp 1647 10 of of IN cord-015306-us58wwmp 1647 11 rat rat NN cord-015306-us58wwmp 1647 12 respiratory respiratory JJ cord-015306-us58wwmp 1647 13 syncytial syncytial JJ cord-015306-us58wwmp 1647 14 virus virus NN cord-015306-us58wwmp 1647 15 ( ( -LRB- cord-015306-us58wwmp 1647 16 RSV RSV NNP cord-015306-us58wwmp 1647 17 ) ) -RRB- cord-015306-us58wwmp 1647 18 nephropathy nephropathy NN cord-015306-us58wwmp 1647 19 . . . cord-015306-us58wwmp 1648 1 Methods method NNS cord-015306-us58wwmp 1648 2 : : : cord-015306-us58wwmp 1648 3 150~200 150~200 LS cord-015306-us58wwmp 1649 1 g g NNP cord-015306-us58wwmp 1649 2 Sprague Sprague NNP cord-015306-us58wwmp 1649 3 - - HYPH cord-015306-us58wwmp 1649 4 Dawley(SD Dawley(SD NNP cord-015306-us58wwmp 1649 5 ) ) -RRB- cord-015306-us58wwmp 1649 6 rats rat NNS cord-015306-us58wwmp 1649 7 ( ( -LRB- cord-015306-us58wwmp 1649 8 n=5 n=5 JJ cord-015306-us58wwmp 1649 9 per per IN cord-015306-us58wwmp 1649 10 group group NN cord-015306-us58wwmp 1649 11 ) ) -RRB- cord-015306-us58wwmp 1649 12 were be VBD cord-015306-us58wwmp 1649 13 inoculated inoculate VBN cord-015306-us58wwmp 1649 14 with with IN cord-015306-us58wwmp 1649 15 6×10 6×10 CD cord-015306-us58wwmp 1649 16 6 6 CD cord-015306-us58wwmp 1649 17 ( ( -LRB- cord-015306-us58wwmp 1649 18 plaque plaque NN cord-015306-us58wwmp 1649 19 - - HYPH cord-015306-us58wwmp 1649 20 forming form VBG cord-015306-us58wwmp 1649 21 units unit NNS cord-015306-us58wwmp 1649 22 , , , cord-015306-us58wwmp 1649 23 PFU pfu NN cord-015306-us58wwmp 1649 24 ) ) -RRB- cord-015306-us58wwmp 1649 25 RSV RSV NNP cord-015306-us58wwmp 1649 26 and and CC cord-015306-us58wwmp 1649 27 sacrificed sacrifice VBD cord-015306-us58wwmp 1649 28 on on IN cord-015306-us58wwmp 1649 29 days day NNS cord-015306-us58wwmp 1649 30 4,8,14 4,8,14 CD cord-015306-us58wwmp 1649 31 and and CC cord-015306-us58wwmp 1649 32 28 28 CD cord-015306-us58wwmp 1649 33 postinoculation postinoculation NN cord-015306-us58wwmp 1649 34 ( ( -LRB- cord-015306-us58wwmp 1649 35 RSV RSV NNP cord-015306-us58wwmp 1649 36 4 4 CD cord-015306-us58wwmp 1649 37 , , , cord-015306-us58wwmp 1649 38 RSV RSV NNP cord-015306-us58wwmp 1649 39 8 8 CD cord-015306-us58wwmp 1649 40 , , , cord-015306-us58wwmp 1649 41 RSV RSV NNP cord-015306-us58wwmp 1649 42 l4 l4 NNP cord-015306-us58wwmp 1649 43 and and CC cord-015306-us58wwmp 1649 44 RSV RSV NNP cord-015306-us58wwmp 1649 45 28 28 CD cord-015306-us58wwmp 1649 46 ) ) -RRB- cord-015306-us58wwmp 1649 47 . . . cord-015306-us58wwmp 1650 1 Five five CD cord-015306-us58wwmp 1650 2 normal normal JJ cord-015306-us58wwmp 1650 3 SD sd NN cord-015306-us58wwmp 1650 4 rats rat NNS cord-015306-us58wwmp 1650 5 inoculated inoculate VBN cord-015306-us58wwmp 1650 6 with with IN cord-015306-us58wwmp 1650 7 Dulbecco Dulbecco NNP cord-015306-us58wwmp 1650 8 's 's POS cord-015306-us58wwmp 1650 9 minimum minimum JJ cord-015306-us58wwmp 1650 10 essential essential JJ cord-015306-us58wwmp 1650 11 medium medium NN cord-015306-us58wwmp 1650 12 were be VBD cord-015306-us58wwmp 1650 13 served serve VBN cord-015306-us58wwmp 1650 14 as as IN cord-015306-us58wwmp 1650 15 normal normal JJ cord-015306-us58wwmp 1650 16 control control NN cord-015306-us58wwmp 1650 17 . . . cord-015306-us58wwmp 1651 1 The the DT cord-015306-us58wwmp 1651 2 expression expression NN cord-015306-us58wwmp 1651 3 level level NN cord-015306-us58wwmp 1651 4 of of IN cord-015306-us58wwmp 1651 5 heparanase heparanase NNP cord-015306-us58wwmp 1651 6 protein protein NNP cord-015306-us58wwmp 1651 7 and and CC cord-015306-us58wwmp 1651 8 mRNA mrna NN cord-015306-us58wwmp 1651 9 in in IN cord-015306-us58wwmp 1651 10 kidney kidney NN cord-015306-us58wwmp 1651 11 of of IN cord-015306-us58wwmp 1651 12 each each DT cord-015306-us58wwmp 1651 13 group group NN cord-015306-us58wwmp 1651 14 was be VBD cord-015306-us58wwmp 1651 15 determined determine VBN cord-015306-us58wwmp 1651 16 by by IN cord-015306-us58wwmp 1651 17 immunohistochemical immunohistochemical JJ cord-015306-us58wwmp 1651 18 staining staining NN cord-015306-us58wwmp 1651 19 and and CC cord-015306-us58wwmp 1651 20 real real JJ cord-015306-us58wwmp 1651 21 - - HYPH cord-015306-us58wwmp 1651 22 time time NN cord-015306-us58wwmp 1651 23 quantitative quantitative JJ cord-015306-us58wwmp 1651 24 RT RT NNP cord-015306-us58wwmp 1651 25 - - HYPH cord-015306-us58wwmp 1651 26 PCR PCR NNP cord-015306-us58wwmp 1651 27 respectively respectively RB cord-015306-us58wwmp 1651 28 . . . cord-015306-us58wwmp 1652 1 The the DT cord-015306-us58wwmp 1652 2 proteinurina proteinurina NN cord-015306-us58wwmp 1652 3 was be VBD cord-015306-us58wwmp 1652 4 measured measure VBN cord-015306-us58wwmp 1652 5 and and CC cord-015306-us58wwmp 1652 6 the the DT cord-015306-us58wwmp 1652 7 relationship relationship NN cord-015306-us58wwmp 1652 8 between between IN cord-015306-us58wwmp 1652 9 the the DT cord-015306-us58wwmp 1652 10 expression expression NN cord-015306-us58wwmp 1652 11 level level NN cord-015306-us58wwmp 1652 12 of of IN cord-015306-us58wwmp 1652 13 heparanase heparanase NN cord-015306-us58wwmp 1652 14 and and CC cord-015306-us58wwmp 1652 15 the the DT cord-015306-us58wwmp 1652 16 24hour 24hour JJ cord-015306-us58wwmp 1652 17 urinary urinary JJ cord-015306-us58wwmp 1652 18 protein protein NN cord-015306-us58wwmp 1652 19 was be VBD cord-015306-us58wwmp 1652 20 studied study VBN cord-015306-us58wwmp 1652 21 . . . cord-015306-us58wwmp 1653 1 Results result NNS cord-015306-us58wwmp 1653 2 : : : cord-015306-us58wwmp 1654 1 Rats rat NNS cord-015306-us58wwmp 1654 2 with with IN cord-015306-us58wwmp 1654 3 RSV RSV NNP cord-015306-us58wwmp 1654 4 nephropathy nephropathy NN cord-015306-us58wwmp 1654 5 exhibited exhibit VBD cord-015306-us58wwmp 1654 6 higher high JJR cord-015306-us58wwmp 1654 7 proteinuria proteinuria NN cord-015306-us58wwmp 1654 8 by by IN cord-015306-us58wwmp 1654 9 comparison comparison NN cord-015306-us58wwmp 1654 10 with with IN cord-015306-us58wwmp 1654 11 normal normal JJ cord-015306-us58wwmp 1654 12 rats rat NNS cord-015306-us58wwmp 1654 13 . . . cord-015306-us58wwmp 1655 1 There there EX cord-015306-us58wwmp 1655 2 was be VBD cord-015306-us58wwmp 1655 3 a a DT cord-015306-us58wwmp 1655 4 significant significant JJ cord-015306-us58wwmp 1655 5 difference difference NN cord-015306-us58wwmp 1655 6 between between IN cord-015306-us58wwmp 1655 7 each each DT cord-015306-us58wwmp 1655 8 group(RSV group(RSV NNP cord-015306-us58wwmp 1655 9 14 14 CD cord-015306-us58wwmp 1656 1 > > XX cord-015306-us58wwmp 1657 1 RSV RSV NNP cord-015306-us58wwmp 1657 2 8 8 CD cord-015306-us58wwmp 1657 3 > > XX cord-015306-us58wwmp 1658 1 RSV RSV NNP cord-015306-us58wwmp 1658 2 28 28 CD cord-015306-us58wwmp 1659 1 > > XX cord-015306-us58wwmp 1660 1 RSV RSV NNP cord-015306-us58wwmp 1660 2 4 4 CD cord-015306-us58wwmp 1660 3 ) ) -RRB- cord-015306-us58wwmp 1660 4 . . . cord-015306-us58wwmp 1661 1 Compared compare VBN cord-015306-us58wwmp 1661 2 with with IN cord-015306-us58wwmp 1661 3 normal normal JJ cord-015306-us58wwmp 1661 4 control control NN cord-015306-us58wwmp 1661 5 , , , cord-015306-us58wwmp 1661 6 Rats Rats NNP cord-015306-us58wwmp 1661 7 with with IN cord-015306-us58wwmp 1661 8 RSV RSV NNP cord-015306-us58wwmp 1661 9 nephropathy nephropathy NN cord-015306-us58wwmp 1661 10 showed show VBD cord-015306-us58wwmp 1661 11 up up RB cord-015306-us58wwmp 1661 12 - - HYPH cord-015306-us58wwmp 1661 13 regulated regulate VBN cord-015306-us58wwmp 1661 14 expression expression NN cord-015306-us58wwmp 1661 15 of of IN cord-015306-us58wwmp 1661 16 heparanase heparanase NN cord-015306-us58wwmp 1661 17 protein protein NN cord-015306-us58wwmp 1661 18 in in IN cord-015306-us58wwmp 1661 19 glomeruli glomerulus NNS cord-015306-us58wwmp 1661 20 . . . cord-015306-us58wwmp 1662 1 The the DT cord-015306-us58wwmp 1662 2 expression expression NN cord-015306-us58wwmp 1662 3 level level NN cord-015306-us58wwmp 1662 4 of of IN cord-015306-us58wwmp 1662 5 heparanase heparanase NN cord-015306-us58wwmp 1662 6 protein protein NN cord-015306-us58wwmp 1662 7 in in IN cord-015306-us58wwmp 1662 8 RSV RSV NNP cord-015306-us58wwmp 1662 9 8 8 CD cord-015306-us58wwmp 1662 10 and and CC cord-015306-us58wwmp 1662 11 RSV RSV NNP cord-015306-us58wwmp 1662 12 14 14 CD cord-015306-us58wwmp 1662 13 group group NN cord-015306-us58wwmp 1662 14 was be VBD cord-015306-us58wwmp 1662 15 higher high JJR cord-015306-us58wwmp 1662 16 than than IN cord-015306-us58wwmp 1662 17 that that DT cord-015306-us58wwmp 1662 18 in in IN cord-015306-us58wwmp 1662 19 RSV RSV NNP cord-015306-us58wwmp 1662 20 4 4 CD cord-015306-us58wwmp 1662 21 and and CC cord-015306-us58wwmp 1662 22 RSV RSV NNP cord-015306-us58wwmp 1662 23 28 28 CD cord-015306-us58wwmp 1662 24 group group NN cord-015306-us58wwmp 1662 25 . . . cord-015306-us58wwmp 1663 1 There there EX cord-015306-us58wwmp 1663 2 was be VBD cord-015306-us58wwmp 1663 3 a a DT cord-015306-us58wwmp 1663 4 linear linear JJ cord-015306-us58wwmp 1663 5 positive positive JJ cord-015306-us58wwmp 1663 6 correlation correlation NN cord-015306-us58wwmp 1663 7 between between IN cord-015306-us58wwmp 1663 8 the the DT cord-015306-us58wwmp 1663 9 expression expression NN cord-015306-us58wwmp 1663 10 level level NN cord-015306-us58wwmp 1663 11 of of IN cord-015306-us58wwmp 1663 12 glomerular glomerular JJ cord-015306-us58wwmp 1663 13 heparanase heparanase NN cord-015306-us58wwmp 1663 14 protein protein NN cord-015306-us58wwmp 1663 15 and and CC cord-015306-us58wwmp 1663 16 the the DT cord-015306-us58wwmp 1663 17 quantity quantity NN cord-015306-us58wwmp 1663 18 of of IN cord-015306-us58wwmp 1663 19 urinary urinary JJ cord-015306-us58wwmp 1663 20 protein(r protein(r NNS cord-015306-us58wwmp 1664 1 = = LS cord-015306-us58wwmp 1664 2 0.783,P<0.05).Compared 0.783,p<0.05).compare VBN cord-015306-us58wwmp 1664 3 with with IN cord-015306-us58wwmp 1664 4 normal normal JJ cord-015306-us58wwmp 1664 5 control control NN cord-015306-us58wwmp 1664 6 group group NN cord-015306-us58wwmp 1664 7 , , , cord-015306-us58wwmp 1664 8 the the DT cord-015306-us58wwmp 1664 9 expression expression NN cord-015306-us58wwmp 1664 10 level level NN cord-015306-us58wwmp 1664 11 of of IN cord-015306-us58wwmp 1664 12 heparanase heparanase NNP cord-015306-us58wwmp 1664 13 mRNA mRNA NNP cord-015306-us58wwmp 1664 14 in in IN cord-015306-us58wwmp 1664 15 kidney kidney NN cord-015306-us58wwmp 1664 16 f f NN cord-015306-us58wwmp 1664 17 r r NN cord-015306-us58wwmp 1664 18 o o NN cord-015306-us58wwmp 1664 19 m m NN cord-015306-us58wwmp 1664 20 R r NN cord-015306-us58wwmp 1664 21 S s NN cord-015306-us58wwmp 1664 22 V v NN cord-015306-us58wwmp 1664 23 4 4 CD cord-015306-us58wwmp 1664 24 , , , cord-015306-us58wwmp 1664 25 RSV RSV NNP cord-015306-us58wwmp 1664 26 8 8 CD cord-015306-us58wwmp 1664 27 , , , cord-015306-us58wwmp 1664 28 RSV RSV NNP cord-015306-us58wwmp 1664 29 1 1 CD cord-015306-us58wwmp 1664 30 4 4 CD cord-015306-us58wwmp 1664 31 a a DT cord-015306-us58wwmp 1664 32 n n NN cord-015306-us58wwmp 1664 33 d d NN cord-015306-us58wwmp 1664 34 R r NN cord-015306-us58wwmp 1664 35 S s NN cord-015306-us58wwmp 1664 36 V v NN cord-015306-us58wwmp 1664 37 2 2 CD cord-015306-us58wwmp 1664 38 8 8 CD cord-015306-us58wwmp 1665 1 g g NNP cord-015306-us58wwmp 1666 1 r r LS cord-015306-us58wwmp 1666 2 o o NN cord-015306-us58wwmp 1666 3 u u NN cord-015306-us58wwmp 1666 4 p p NN cord-015306-us58wwmp 1666 5 w w NN cord-015306-us58wwmp 1666 6 a a DT cord-015306-us58wwmp 1666 7 s s NN cord-015306-us58wwmp 1667 1 elevated(RSV elevated(RSV NFP cord-015306-us58wwmp 1667 2 14 14 CD cord-015306-us58wwmp 1668 1 > > XX cord-015306-us58wwmp 1669 1 RSV RSV NNP cord-015306-us58wwmp 1669 2 8 8 CD cord-015306-us58wwmp 1669 3 > > XX cord-015306-us58wwmp 1670 1 RSV RSV NNP cord-015306-us58wwmp 1670 2 4 4 CD cord-015306-us58wwmp 1671 1 > > XX cord-015306-us58wwmp 1672 1 RSV RSV NNP cord-015306-us58wwmp 1672 2 28 28 CD cord-015306-us58wwmp 1672 3 ) ) -RRB- cord-015306-us58wwmp 1673 1 .There .There , cord-015306-us58wwmp 1673 2 was be VBD cord-015306-us58wwmp 1673 3 a a DT cord-015306-us58wwmp 1673 4 linear linear JJ cord-015306-us58wwmp 1673 5 positive positive JJ cord-015306-us58wwmp 1673 6 correlation correlation NN cord-015306-us58wwmp 1673 7 between between IN cord-015306-us58wwmp 1673 8 the the DT cord-015306-us58wwmp 1673 9 expression expression NN cord-015306-us58wwmp 1673 10 level level NN cord-015306-us58wwmp 1673 11 of of IN cord-015306-us58wwmp 1673 12 renal renal JJ cord-015306-us58wwmp 1673 13 heparanase heparanase NNP cord-015306-us58wwmp 1673 14 mRNA mRNA NNP cord-015306-us58wwmp 1673 15 and and CC cord-015306-us58wwmp 1673 16 the the DT cord-015306-us58wwmp 1673 17 24-hour 24-hour JJ cord-015306-us58wwmp 1673 18 urinary urinary JJ cord-015306-us58wwmp 1673 19 protein(r=0.725,P<0.05 protein(r=0.725,p<0.05 NN cord-015306-us58wwmp 1673 20 ) ) -RRB- cord-015306-us58wwmp 1673 21 . . . cord-015306-us58wwmp 1674 1 The the DT cord-015306-us58wwmp 1674 2 increased increase VBN cord-015306-us58wwmp 1674 3 heparanase heparanase NN cord-015306-us58wwmp 1674 4 in in IN cord-015306-us58wwmp 1674 5 kidney kidney NN cord-015306-us58wwmp 1674 6 may may MD cord-015306-us58wwmp 1674 7 be be VB cord-015306-us58wwmp 1674 8 important important JJ cord-015306-us58wwmp 1674 9 to to IN cord-015306-us58wwmp 1674 10 the the DT cord-015306-us58wwmp 1674 11 loss loss NN cord-015306-us58wwmp 1674 12 of of IN cord-015306-us58wwmp 1674 13 glomerular glomerular JJ cord-015306-us58wwmp 1674 14 negative negative JJ cord-015306-us58wwmp 1674 15 charge charge NN cord-015306-us58wwmp 1674 16 in in IN cord-015306-us58wwmp 1674 17 glomerular glomerular JJ cord-015306-us58wwmp 1674 18 basement basement NN cord-015306-us58wwmp 1674 19 membrane membrane NN cord-015306-us58wwmp 1674 20 and and CC cord-015306-us58wwmp 1674 21 is be VBZ cord-015306-us58wwmp 1674 22 involved involve VBN cord-015306-us58wwmp 1674 23 in in IN cord-015306-us58wwmp 1674 24 the the DT cord-015306-us58wwmp 1674 25 pathogenesis pathogenesis NN cord-015306-us58wwmp 1674 26 of of IN cord-015306-us58wwmp 1674 27 RSV RSV NNP cord-015306-us58wwmp 1674 28 nephropathy nephropathy NN cord-015306-us58wwmp 1674 29 . . . cord-015306-us58wwmp 1675 1 Podocyte Podocyte NNP cord-015306-us58wwmp 1675 2 morphology morphology NN cord-015306-us58wwmp 1675 3 andautophagosomes andautophagosome NNS cord-015306-us58wwmp 1675 4 were be VBD cord-015306-us58wwmp 1675 5 viewed view VBN cord-015306-us58wwmp 1675 6 using use VBG cord-015306-us58wwmp 1675 7 electron electron NN cord-015306-us58wwmp 1675 8 microscopy microscopy NN cord-015306-us58wwmp 1675 9 . . . cord-015306-us58wwmp 1676 1 Podocyte Podocyte NNP cord-015306-us58wwmp 1676 2 numerical numerical JJ cord-015306-us58wwmp 1676 3 density density NN cord-015306-us58wwmp 1676 4 was be VBD cord-015306-us58wwmp 1676 5 estimated estimate VBN cord-015306-us58wwmp 1676 6 by by IN cord-015306-us58wwmp 1676 7 Weibel Weibel NNP cord-015306-us58wwmp 1676 8 - - HYPH cord-015306-us58wwmp 1676 9 Gomez Gomez NNP cord-015306-us58wwmp 1676 10 method method NN cord-015306-us58wwmp 1676 11 . . . cord-015306-us58wwmp 1677 1 Expressions expression NNS cord-015306-us58wwmp 1677 2 of of IN cord-015306-us58wwmp 1677 3 autophagy autophagy NN cord-015306-us58wwmp 1677 4 markers marker NNS cord-015306-us58wwmp 1677 5 and and CC cord-015306-us58wwmp 1677 6 ERSassociated ersassociate VBN cord-015306-us58wwmp 1677 7 proteins protein NNS cord-015306-us58wwmp 1677 8 were be VBD cord-015306-us58wwmp 1677 9 analyzed analyze VBN cord-015306-us58wwmp 1677 10 by by IN cord-015306-us58wwmp 1677 11 Western western JJ cord-015306-us58wwmp 1677 12 blot blot NN cord-015306-us58wwmp 1677 13 . . . cord-015306-us58wwmp 1678 1 Results result NNS cord-015306-us58wwmp 1678 2 : : : cord-015306-us58wwmp 1679 1 The the DT cord-015306-us58wwmp 1679 2 expression expression NN cord-015306-us58wwmp 1679 3 level level NN cord-015306-us58wwmp 1679 4 of of IN cord-015306-us58wwmp 1679 5 ERS ERS NNP cord-015306-us58wwmp 1679 6 - - HYPH cord-015306-us58wwmp 1679 7 associated associate VBN cord-015306-us58wwmp 1679 8 protein protein NN cord-015306-us58wwmp 1679 9 GRP78 GRP78 NNP cord-015306-us58wwmp 1679 10 was be VBD cord-015306-us58wwmp 1679 11 up up RB cord-015306-us58wwmp 1679 12 - - HYPH cord-015306-us58wwmp 1679 13 regulated regulate VBN cord-015306-us58wwmp 1679 14 from from IN cord-015306-us58wwmp 1679 15 day day NN cord-015306-us58wwmp 1679 16 4 4 CD cord-015306-us58wwmp 1679 17 to to IN cord-015306-us58wwmp 1679 18 day day NN cord-015306-us58wwmp 1679 19 21 21 CD cord-015306-us58wwmp 1679 20 post post NN cord-015306-us58wwmp 1679 21 - - NN cord-015306-us58wwmp 1679 22 injection injection NN cord-015306-us58wwmp 1679 23 . . . cord-015306-us58wwmp 1680 1 The the DT cord-015306-us58wwmp 1680 2 results result NNS cord-015306-us58wwmp 1680 3 also also RB cord-015306-us58wwmp 1680 4 showed show VBD cord-015306-us58wwmp 1680 5 that that IN cord-015306-us58wwmp 1680 6 autophagosomes autophagosomes NNP cord-015306-us58wwmp 1680 7 were be VBD cord-015306-us58wwmp 1680 8 massively massively RB cord-015306-us58wwmp 1680 9 accumulated accumulate VBN cord-015306-us58wwmp 1680 10 and and CC cord-015306-us58wwmp 1681 1 the the DT cord-015306-us58wwmp 1681 2 autophagy autophagy NN cord-015306-us58wwmp 1681 3 marker marker NN cord-015306-us58wwmp 1681 4 LC3 LC3 NNP cord-015306-us58wwmp 1681 5 was be VBD cord-015306-us58wwmp 1681 6 up up RB cord-015306-us58wwmp 1681 7 - - HYPH cord-015306-us58wwmp 1681 8 regulated regulate VBN cord-015306-us58wwmp 1681 9 in in IN cord-015306-us58wwmp 1681 10 the the DT cord-015306-us58wwmp 1681 11 models model NNS cord-015306-us58wwmp 1681 12 on on IN cord-015306-us58wwmp 1681 13 day day NN cord-015306-us58wwmp 1681 14 7 7 CD cord-015306-us58wwmp 1681 15 and and CC cord-015306-us58wwmp 1681 16 14 14 CD cord-015306-us58wwmp 1681 17 . . . cord-015306-us58wwmp 1682 1 Furthermore furthermore RB cord-015306-us58wwmp 1682 2 , , , cord-015306-us58wwmp 1682 3 rapamycin rapamycin NN cord-015306-us58wwmp 1682 4 was be VBD cord-015306-us58wwmp 1682 5 given give VBN cord-015306-us58wwmp 1682 6 to to IN cord-015306-us58wwmp 1682 7 PHN PHN NNP cord-015306-us58wwmp 1682 8 rats rat NNS cord-015306-us58wwmp 1682 9 to to TO cord-015306-us58wwmp 1682 10 further further RB cord-015306-us58wwmp 1682 11 explore explore VB cord-015306-us58wwmp 1682 12 the the DT cord-015306-us58wwmp 1682 13 role role NN cord-015306-us58wwmp 1682 14 of of IN cord-015306-us58wwmp 1682 15 autophagy autophagy NN cord-015306-us58wwmp 1682 16 in in IN cord-015306-us58wwmp 1682 17 the the DT cord-015306-us58wwmp 1682 18 process process NN cord-015306-us58wwmp 1682 19 of of IN cord-015306-us58wwmp 1682 20 complement complement NN cord-015306-us58wwmp 1682 21 - - HYPH cord-015306-us58wwmp 1682 22 dependent dependent JJ cord-015306-us58wwmp 1682 23 podocyte podocyte NNP cord-015306-us58wwmp 1682 24 injury injury NN cord-015306-us58wwmp 1682 25 . . . cord-015306-us58wwmp 1683 1 Results result NNS cord-015306-us58wwmp 1683 2 revealed reveal VBD cord-015306-us58wwmp 1683 3 that that IN cord-015306-us58wwmp 1683 4 rapamycin rapamycin NN cord-015306-us58wwmp 1683 5 , , , cord-015306-us58wwmp 1683 6 which which WDT cord-015306-us58wwmp 1683 7 enhanced enhance VBD cord-015306-us58wwmp 1683 8 autophagy autophagy NN cord-015306-us58wwmp 1683 9 in in IN cord-015306-us58wwmp 1683 10 podocyte podocyte NNP cord-015306-us58wwmp 1683 11 , , , cord-015306-us58wwmp 1683 12 could could MD cord-015306-us58wwmp 1683 13 reduce reduce VB cord-015306-us58wwmp 1683 14 proteinuria proteinuria NN cord-015306-us58wwmp 1683 15 , , , cord-015306-us58wwmp 1683 16 lighten lighten VB cord-015306-us58wwmp 1683 17 podocyte podocyte NNP cord-015306-us58wwmp 1683 18 lesionsand lesionsand NNP cord-015306-us58wwmp 1683 19 prevent prevent VB cord-015306-us58wwmp 1683 20 podocyte podocyte NNP cord-015306-us58wwmp 1683 21 loss loss NN cord-015306-us58wwmp 1683 22 on on IN cord-015306-us58wwmp 1683 23 day day NN cord-015306-us58wwmp 1683 24 21 21 CD cord-015306-us58wwmp 1683 25 . . . cord-015306-us58wwmp 1684 1 Conclusion conclusion NN cord-015306-us58wwmp 1684 2 : : : cord-015306-us58wwmp 1684 3 Taken take VBN cord-015306-us58wwmp 1684 4 together together RB cord-015306-us58wwmp 1685 1 , , , cord-015306-us58wwmp 1685 2 our -PRON- PRP$ cord-015306-us58wwmp 1685 3 results result NNS cord-015306-us58wwmp 1685 4 demonstrated demonstrate VBD cord-015306-us58wwmp 1685 5 that that IN cord-015306-us58wwmp 1685 6 ERS ERS NNP cord-015306-us58wwmp 1685 7 plays play VBZ cord-015306-us58wwmp 1685 8 an an DT cord-015306-us58wwmp 1685 9 important important JJ cord-015306-us58wwmp 1685 10 role role NN cord-015306-us58wwmp 1685 11 in in IN cord-015306-us58wwmp 1685 12 completment completment NN cord-015306-us58wwmp 1685 13 - - HYPH cord-015306-us58wwmp 1685 14 dependent dependent JJ cord-015306-us58wwmp 1685 15 podocyte podocyte NNP cord-015306-us58wwmp 1685 16 damage damage NN cord-015306-us58wwmp 1685 17 , , , cord-015306-us58wwmp 1685 18 and and CC cord-015306-us58wwmp 1685 19 in in IN cord-015306-us58wwmp 1685 20 another another DT cord-015306-us58wwmp 1685 21 aspect aspect NN cord-015306-us58wwmp 1685 22 , , , cord-015306-us58wwmp 1685 23 autophagy autophagy NN cord-015306-us58wwmp 1685 24 induced induce VBN cord-015306-us58wwmp 1685 25 byERS byers RB cord-015306-us58wwmp 1685 26 can can MD cord-015306-us58wwmp 1685 27 alleviate alleviate VB cord-015306-us58wwmp 1685 28 injury injury NN cord-015306-us58wwmp 1685 29 as as IN cord-015306-us58wwmp 1685 30 a a DT cord-015306-us58wwmp 1685 31 protective protective JJ cord-015306-us58wwmp 1685 32 mechanism mechanism NN cord-015306-us58wwmp 1685 33 . . . cord-015306-us58wwmp 1686 1 This this DT cord-015306-us58wwmp 1686 2 provides provide VBZ cord-015306-us58wwmp 1686 3 an an DT cord-015306-us58wwmp 1686 4 important important JJ cord-015306-us58wwmp 1686 5 basis basis NN cord-015306-us58wwmp 1686 6 for for IN cord-015306-us58wwmp 1686 7 a a DT cord-015306-us58wwmp 1686 8 thorough thorough JJ cord-015306-us58wwmp 1686 9 understanding understanding NN cord-015306-us58wwmp 1686 10 of of IN cord-015306-us58wwmp 1686 11 the the DT cord-015306-us58wwmp 1686 12 role role NN cord-015306-us58wwmp 1686 13 of of IN cord-015306-us58wwmp 1686 14 autophagy autophagy NN cord-015306-us58wwmp 1686 15 in in IN cord-015306-us58wwmp 1686 16 the the DT cord-015306-us58wwmp 1686 17 process process NN cord-015306-us58wwmp 1686 18 of of IN cord-015306-us58wwmp 1686 19 podocyte podocyte NNP cord-015306-us58wwmp 1686 20 damage damage NN cord-015306-us58wwmp 1686 21 and and CC cord-015306-us58wwmp 1686 22 the the DT cord-015306-us58wwmp 1686 23 pathogenesis pathogenesis NN cord-015306-us58wwmp 1686 24 of of IN cord-015306-us58wwmp 1686 25 MN MN NNP cord-015306-us58wwmp 1686 26 . . . cord-015306-us58wwmp 1687 1 Abstract abstract JJ cord-015306-us58wwmp 1687 2 # # NN cord-015306-us58wwmp 1687 3 P p NN cord-015306-us58wwmp 1687 4 - - HYPH cord-015306-us58wwmp 1687 5 SAT209 SAT209 NNP cord-015306-us58wwmp 1688 1 The the DT cord-015306-us58wwmp 1688 2 cytoprotective cytoprotective JJ cord-015306-us58wwmp 1688 3 role role NN cord-015306-us58wwmp 1688 4 of of IN cord-015306-us58wwmp 1688 5 autophagy autophagy NN cord-015306-us58wwmp 1688 6 under under IN cord-015306-us58wwmp 1688 7 oxidative oxidative JJ cord-015306-us58wwmp 1688 8 stress stress NN cord-015306-us58wwmp 1688 9 in in IN cord-015306-us58wwmp 1688 10 human human JJ cord-015306-us58wwmp 1688 11 podocyte podocyte NNP cord-015306-us58wwmp 1688 12 Objective Objective NNP cord-015306-us58wwmp 1688 13 : : : cord-015306-us58wwmp 1688 14 Autophagy Autophagy NNP cord-015306-us58wwmp 1688 15 is be VBZ cord-015306-us58wwmp 1688 16 a a DT cord-015306-us58wwmp 1688 17 ubiquitous ubiquitous JJ cord-015306-us58wwmp 1688 18 catabolic catabolic JJ cord-015306-us58wwmp 1688 19 process process NN cord-015306-us58wwmp 1688 20 involving involve VBG cord-015306-us58wwmp 1688 21 selective selective JJ cord-015306-us58wwmp 1688 22 degradation degradation NN cord-015306-us58wwmp 1688 23 of of IN cord-015306-us58wwmp 1688 24 cellular cellular JJ cord-015306-us58wwmp 1688 25 components component NNS cord-015306-us58wwmp 1688 26 . . . cord-015306-us58wwmp 1689 1 It -PRON- PRP cord-015306-us58wwmp 1689 2 shows show VBZ cord-015306-us58wwmp 1689 3 cytoprotective cytoprotective JJ cord-015306-us58wwmp 1689 4 effects effect NNS cord-015306-us58wwmp 1689 5 in in IN cord-015306-us58wwmp 1689 6 different different JJ cord-015306-us58wwmp 1689 7 cell cell NN cord-015306-us58wwmp 1689 8 types type NNS cord-015306-us58wwmp 1689 9 and and CC cord-015306-us58wwmp 1689 10 helps help VBZ cord-015306-us58wwmp 1689 11 to to TO cord-015306-us58wwmp 1689 12 maintain maintain VB cord-015306-us58wwmp 1689 13 cell cell NN cord-015306-us58wwmp 1689 14 homeostasis homeostasis NN cord-015306-us58wwmp 1689 15 . . . cord-015306-us58wwmp 1690 1 Some some DT cord-015306-us58wwmp 1690 2 studies study NNS cord-015306-us58wwmp 1690 3 demonstrated demonstrate VBD cord-015306-us58wwmp 1690 4 that that IN cord-015306-us58wwmp 1690 5 cell cell NN cord-015306-us58wwmp 1690 6 stress stress NN cord-015306-us58wwmp 1690 7 , , , cord-015306-us58wwmp 1690 8 generated generate VBN cord-015306-us58wwmp 1690 9 by by IN cord-015306-us58wwmp 1690 10 starvation starvation NN cord-015306-us58wwmp 1690 11 or or CC cord-015306-us58wwmp 1690 12 some some DT cord-015306-us58wwmp 1690 13 chemical chemical JJ cord-015306-us58wwmp 1690 14 reagents reagent NNS cord-015306-us58wwmp 1690 15 , , , cord-015306-us58wwmp 1690 16 can can MD cord-015306-us58wwmp 1690 17 initiate initiate VB cord-015306-us58wwmp 1690 18 autophagy autophagy NN cord-015306-us58wwmp 1690 19 which which WDT cord-015306-us58wwmp 1690 20 responsively responsively RB cord-015306-us58wwmp 1690 21 resists resist VBZ cord-015306-us58wwmp 1690 22 harmful harmful JJ cord-015306-us58wwmp 1690 23 stimuli stimulus NNS cord-015306-us58wwmp 1690 24 at at IN cord-015306-us58wwmp 1690 25 the the DT cord-015306-us58wwmp 1690 26 early early JJ cord-015306-us58wwmp 1690 27 stage stage NN cord-015306-us58wwmp 1690 28 . . . cord-015306-us58wwmp 1691 1 However however RB cord-015306-us58wwmp 1691 2 , , , cord-015306-us58wwmp 1691 3 little little JJ cord-015306-us58wwmp 1691 4 is be VBZ cord-015306-us58wwmp 1691 5 known know VBN cord-015306-us58wwmp 1691 6 about about IN cord-015306-us58wwmp 1691 7 autophagy autophagy NN cord-015306-us58wwmp 1691 8 in in IN cord-015306-us58wwmp 1691 9 human human JJ cord-015306-us58wwmp 1691 10 podocytes podocyte NNS cord-015306-us58wwmp 1691 11 under under IN cord-015306-us58wwmp 1691 12 oxidative oxidative JJ cord-015306-us58wwmp 1691 13 stress stress NN cord-015306-us58wwmp 1691 14 . . . cord-015306-us58wwmp 1692 1 Since since IN cord-015306-us58wwmp 1692 2 the the DT cord-015306-us58wwmp 1692 3 apoptosis apoptosis NN cord-015306-us58wwmp 1692 4 and and CC cord-015306-us58wwmp 1692 5 autophagy autophagy NN cord-015306-us58wwmp 1692 6 pathways pathway NNS cord-015306-us58wwmp 1692 7 share share VBP cord-015306-us58wwmp 1692 8 some some DT cord-015306-us58wwmp 1692 9 common common JJ cord-015306-us58wwmp 1692 10 molecules molecule NNS cord-015306-us58wwmp 1692 11 , , , cord-015306-us58wwmp 1692 12 we -PRON- PRP cord-015306-us58wwmp 1692 13 investigated investigate VBD cord-015306-us58wwmp 1692 14 the the DT cord-015306-us58wwmp 1692 15 role role NN cord-015306-us58wwmp 1692 16 of of IN cord-015306-us58wwmp 1692 17 autophagy autophagy NN cord-015306-us58wwmp 1692 18 induced induce VBN cord-015306-us58wwmp 1692 19 by by IN cord-015306-us58wwmp 1692 20 puromycin puromycin NNS cord-015306-us58wwmp 1692 21 aminonucleoside aminonucleoside NNP cord-015306-us58wwmp 1692 22 ( ( -LRB- cord-015306-us58wwmp 1692 23 PAN PAN NNP cord-015306-us58wwmp 1692 24 ) ) -RRB- cord-015306-us58wwmp 1692 25 in in IN cord-015306-us58wwmp 1692 26 human human JJ cord-015306-us58wwmp 1692 27 podocytes podocyte NNS cord-015306-us58wwmp 1692 28 . . . cord-015306-us58wwmp 1693 1 Methods method NNS cord-015306-us58wwmp 1693 2 : : : cord-015306-us58wwmp 1693 3 Human human JJ cord-015306-us58wwmp 1693 4 conditional conditional JJ cord-015306-us58wwmp 1693 5 immortalized immortalize VBN cord-015306-us58wwmp 1693 6 podocytes podocyte NNS cord-015306-us58wwmp 1693 7 were be VBD cord-015306-us58wwmp 1693 8 treated treat VBN cord-015306-us58wwmp 1693 9 with with IN cord-015306-us58wwmp 1693 10 PAN PAN NNP cord-015306-us58wwmp 1693 11 , , , cord-015306-us58wwmp 1693 12 the the DT cord-015306-us58wwmp 1693 13 generation generation NN cord-015306-us58wwmp 1693 14 of of IN cord-015306-us58wwmp 1693 15 reactive reactive JJ cord-015306-us58wwmp 1693 16 oxygen oxygen NN cord-015306-us58wwmp 1693 17 species specie NNS cord-015306-us58wwmp 1693 18 ( ( -LRB- cord-015306-us58wwmp 1693 19 ROS ROS NNP cord-015306-us58wwmp 1693 20 ) ) -RRB- cord-015306-us58wwmp 1693 21 was be VBD cord-015306-us58wwmp 1693 22 measured measure VBN cord-015306-us58wwmp 1693 23 by by IN cord-015306-us58wwmp 1693 24 immunofluorescence immunofluorescence NN cord-015306-us58wwmp 1693 25 . . . cord-015306-us58wwmp 1694 1 Then then RB cord-015306-us58wwmp 1694 2 , , , cord-015306-us58wwmp 1694 3 autophagy autophagy NN cord-015306-us58wwmp 1694 4 was be VBD cord-015306-us58wwmp 1694 5 assayed assay VBN cord-015306-us58wwmp 1694 6 by by IN cord-015306-us58wwmp 1694 7 immunofluorecence immunofluorecence NN cord-015306-us58wwmp 1694 8 staining stain VBG cord-015306-us58wwmp 1694 9 for for IN cord-015306-us58wwmp 1694 10 LC3 LC3 NNP cord-015306-us58wwmp 1694 11 puncta puncta NN cord-015306-us58wwmp 1694 12 and and CC cord-015306-us58wwmp 1694 13 western western JJ cord-015306-us58wwmp 1694 14 blotting blotting NN cord-015306-us58wwmp 1694 15 for for IN cord-015306-us58wwmp 1694 16 LC3 LC3 NNP cord-015306-us58wwmp 1694 17 . . . cord-015306-us58wwmp 1695 1 In in IN cord-015306-us58wwmp 1695 2 addition addition NN cord-015306-us58wwmp 1695 3 , , , cord-015306-us58wwmp 1695 4 the the DT cord-015306-us58wwmp 1695 5 mammalian mammalian JJ cord-015306-us58wwmp 1695 6 target target NN cord-015306-us58wwmp 1695 7 of of IN cord-015306-us58wwmp 1695 8 rapamycin rapamycin NNP cord-015306-us58wwmp 1695 9 ( ( -LRB- cord-015306-us58wwmp 1695 10 mTOR mTOR NNP cord-015306-us58wwmp 1695 11 ) ) -RRB- cord-015306-us58wwmp 1695 12 and and CC cord-015306-us58wwmp 1695 13 its -PRON- PRP$ cord-015306-us58wwmp 1695 14 substrates substrate NNS cord-015306-us58wwmp 1695 15 which which WDT cord-015306-us58wwmp 1695 16 play play VBP cord-015306-us58wwmp 1695 17 critical critical JJ cord-015306-us58wwmp 1695 18 roles role NNS cord-015306-us58wwmp 1695 19 in in IN cord-015306-us58wwmp 1695 20 autophagy autophagy NN cord-015306-us58wwmp 1695 21 inhibition inhibition NN cord-015306-us58wwmp 1695 22 were be VBD cord-015306-us58wwmp 1695 23 investigated investigate VBN cord-015306-us58wwmp 1695 24 for for IN cord-015306-us58wwmp 1695 25 elucidating elucidate VBG cord-015306-us58wwmp 1695 26 the the DT cord-015306-us58wwmp 1695 27 mechanism mechanism NN cord-015306-us58wwmp 1695 28 of of IN cord-015306-us58wwmp 1695 29 PAN PAN NNP cord-015306-us58wwmp 1695 30 induced induce VBN cord-015306-us58wwmp 1695 31 autophagy autophagy NN cord-015306-us58wwmp 1695 32 . . . cord-015306-us58wwmp 1696 1 Podocyte Podocyte NNP cord-015306-us58wwmp 1696 2 apoptosis apoptosis NN cord-015306-us58wwmp 1696 3 was be VBD cord-015306-us58wwmp 1696 4 assessed assess VBN cord-015306-us58wwmp 1696 5 by by IN cord-015306-us58wwmp 1696 6 flow flow NN cord-015306-us58wwmp 1696 7 cytometry cytometry NN cord-015306-us58wwmp 1696 8 ( ( -LRB- cord-015306-us58wwmp 1696 9 YO YO NNP cord-015306-us58wwmp 1696 10 - - HYPH cord-015306-us58wwmp 1696 11 PRO-1 PRO-1 NNP cord-015306-us58wwmp 1696 12 / / SYM cord-015306-us58wwmp 1696 13 PI pi NN cord-015306-us58wwmp 1696 14 and and CC cord-015306-us58wwmp 1696 15 active active JJ cord-015306-us58wwmp 1696 16 caspase caspase NN cord-015306-us58wwmp 1696 17 3 3 CD cord-015306-us58wwmp 1696 18 assays assay NNS cord-015306-us58wwmp 1696 19 ) ) -RRB- cord-015306-us58wwmp 1696 20 . . . cord-015306-us58wwmp 1697 1 To to TO cord-015306-us58wwmp 1697 2 study study VB cord-015306-us58wwmp 1697 3 the the DT cord-015306-us58wwmp 1697 4 effects effect NNS cord-015306-us58wwmp 1697 5 of of IN cord-015306-us58wwmp 1697 6 autophagy autophagy NN cord-015306-us58wwmp 1697 7 on on IN cord-015306-us58wwmp 1697 8 podocyte podocyte JJ cord-015306-us58wwmp 1697 9 apoptosis apoptosis NN cord-015306-us58wwmp 1697 10 , , , cord-015306-us58wwmp 1697 11 3-Methyladenine 3-Methyladenine NNP cord-015306-us58wwmp 1697 12 ( ( -LRB- cord-015306-us58wwmp 1697 13 3-MA 3-ma CD cord-015306-us58wwmp 1697 14 ) ) -RRB- cord-015306-us58wwmp 1697 15 and and CC cord-015306-us58wwmp 1697 16 chloroquine chloroquine NN cord-015306-us58wwmp 1697 17 were be VBD cord-015306-us58wwmp 1697 18 used use VBN cord-015306-us58wwmp 1697 19 to to TO cord-015306-us58wwmp 1697 20 inhibit inhibit VB cord-015306-us58wwmp 1697 21 autophagy autophagy NN cord-015306-us58wwmp 1697 22 . . . cord-015306-us58wwmp 1698 1 Results result NNS cord-015306-us58wwmp 1698 2 : : : cord-015306-us58wwmp 1699 1 Autophagy Autophagy NNP cord-015306-us58wwmp 1699 2 was be VBD cord-015306-us58wwmp 1699 3 detected detect VBN cord-015306-us58wwmp 1699 4 in in IN cord-015306-us58wwmp 1699 5 PAN PAN NNP cord-015306-us58wwmp 1699 6 - - HYPH cord-015306-us58wwmp 1699 7 treated treat VBN cord-015306-us58wwmp 1699 8 podocytes podocyte NNS cord-015306-us58wwmp 1699 9 in in IN cord-015306-us58wwmp 1699 10 a a DT cord-015306-us58wwmp 1699 11 dose dose NN cord-015306-us58wwmp 1699 12 and and CC cord-015306-us58wwmp 1699 13 time time NN cord-015306-us58wwmp 1699 14 dependent dependent JJ cord-015306-us58wwmp 1699 15 manner manner NN cord-015306-us58wwmp 1699 16 and and CC cord-015306-us58wwmp 1699 17 prior prior RB cord-015306-us58wwmp 1699 18 to to IN cord-015306-us58wwmp 1699 19 apoptosis apoptosis NN cord-015306-us58wwmp 1699 20 which which WDT cord-015306-us58wwmp 1699 21 was be VBD cord-015306-us58wwmp 1699 22 accompanied accompany VBN cord-015306-us58wwmp 1699 23 with with IN cord-015306-us58wwmp 1699 24 increased increase VBN cord-015306-us58wwmp 1699 25 ROS ROS NNP cord-015306-us58wwmp 1699 26 generation generation NN cord-015306-us58wwmp 1699 27 . . . cord-015306-us58wwmp 1700 1 LC3 LC3 NNP cord-015306-us58wwmp 1700 2 aggregates aggregate NNS cord-015306-us58wwmp 1700 3 were be VBD cord-015306-us58wwmp 1700 4 observed observe VBN cord-015306-us58wwmp 1700 5 in in IN cord-015306-us58wwmp 1700 6 the the DT cord-015306-us58wwmp 1700 7 cytoplasm cytoplasm NN cord-015306-us58wwmp 1700 8 and and CC cord-015306-us58wwmp 1700 9 the the DT cord-015306-us58wwmp 1700 10 expression expression NN cord-015306-us58wwmp 1700 11 of of IN cord-015306-us58wwmp 1700 12 LC3 LC3 NNP cord-015306-us58wwmp 1700 13 II II NNP cord-015306-us58wwmp 1700 14 was be VBD cord-015306-us58wwmp 1700 15 significantly significantly RB cord-015306-us58wwmp 1700 16 elevated elevate VBN cord-015306-us58wwmp 1700 17 . . . cord-015306-us58wwmp 1701 1 Intriguingly intriguingly RB cord-015306-us58wwmp 1701 2 , , , cord-015306-us58wwmp 1701 3 Phospho Phospho NNP cord-015306-us58wwmp 1701 4 - - HYPH cord-015306-us58wwmp 1701 5 mTOR mTOR NNP cord-015306-us58wwmp 1701 6 and and CC cord-015306-us58wwmp 1701 7 its -PRON- PRP$ cord-015306-us58wwmp 1701 8 substrates substrate NNS cord-015306-us58wwmp 1701 9 ( ( -LRB- cord-015306-us58wwmp 1701 10 Phospho Phospho NNP cord-015306-us58wwmp 1701 11 - - HYPH cord-015306-us58wwmp 1701 12 p70 p70 CD cord-015306-us58wwmp 1701 13 S6 S6 NNP cord-015306-us58wwmp 1701 14 Kinase Kinase NNP cord-015306-us58wwmp 1701 15 and and CC cord-015306-us58wwmp 1701 16 Phospho-4E Phospho-4E NNP cord-015306-us58wwmp 1701 17 - - HYPH cord-015306-us58wwmp 1701 18 BP1 BP1 NNP cord-015306-us58wwmp 1701 19 ) ) -RRB- cord-015306-us58wwmp 1701 20 increased increase VBD cord-015306-us58wwmp 1701 21 when when WRB cord-015306-us58wwmp 1701 22 the the DT cord-015306-us58wwmp 1701 23 autophagy autophagy NN cord-015306-us58wwmp 1701 24 was be VBD cord-015306-us58wwmp 1701 25 activated activate VBN cord-015306-us58wwmp 1701 26 . . . cord-015306-us58wwmp 1702 1 When when WRB cord-015306-us58wwmp 1702 2 autophagy autophagy NN cord-015306-us58wwmp 1702 3 was be VBD cord-015306-us58wwmp 1702 4 inhibited inhibit VBN cord-015306-us58wwmp 1702 5 by by IN cord-015306-us58wwmp 1702 6 3MA 3ma CD cord-015306-us58wwmp 1702 7 and and CC cord-015306-us58wwmp 1702 8 chloroquine chloroquine NN cord-015306-us58wwmp 1702 9 , , , cord-015306-us58wwmp 1702 10 podocyte podocyte NNP cord-015306-us58wwmp 1702 11 apoptosis apoptosis NN cord-015306-us58wwmp 1702 12 increased increase VBD cord-015306-us58wwmp 1702 13 significantly significantly RB cord-015306-us58wwmp 1702 14 . . . cord-015306-us58wwmp 1703 1 Conclusion conclusion NN cord-015306-us58wwmp 1703 2 : : : cord-015306-us58wwmp 1704 1 PAN PAN NNP cord-015306-us58wwmp 1704 2 induced induce VBD cord-015306-us58wwmp 1704 3 both both CC cord-015306-us58wwmp 1704 4 apoptosis apoptosis NN cord-015306-us58wwmp 1704 5 and and CC cord-015306-us58wwmp 1704 6 autophagy autophagy NN cord-015306-us58wwmp 1704 7 in in IN cord-015306-us58wwmp 1704 8 human human JJ cord-015306-us58wwmp 1704 9 podocytes podocyte NNS cord-015306-us58wwmp 1704 10 . . . cord-015306-us58wwmp 1705 1 Our -PRON- PRP$ cord-015306-us58wwmp 1705 2 results result NNS cord-015306-us58wwmp 1705 3 suggested suggest VBD cord-015306-us58wwmp 1705 4 that that IN cord-015306-us58wwmp 1705 5 this this DT cord-015306-us58wwmp 1705 6 in in FW cord-015306-us58wwmp 1705 7 vitro vitro FW cord-015306-us58wwmp 1705 8 model model NN cord-015306-us58wwmp 1705 9 will will MD cord-015306-us58wwmp 1705 10 be be VB cord-015306-us58wwmp 1705 11 useful useful JJ cord-015306-us58wwmp 1705 12 for for IN cord-015306-us58wwmp 1705 13 the the DT cord-015306-us58wwmp 1705 14 study study NN cord-015306-us58wwmp 1705 15 of of IN cord-015306-us58wwmp 1705 16 crosstalk crosstalk NN cord-015306-us58wwmp 1705 17 between between IN cord-015306-us58wwmp 1705 18 apoptosis apoptosis NN cord-015306-us58wwmp 1705 19 and and CC cord-015306-us58wwmp 1705 20 autophagy autophagy NN cord-015306-us58wwmp 1705 21 in in IN cord-015306-us58wwmp 1705 22 podocytes podocyte NNS cord-015306-us58wwmp 1705 23 . . . cord-015306-us58wwmp 1706 1 Autophagy Autophagy NNP cord-015306-us58wwmp 1706 2 may may MD cord-015306-us58wwmp 1706 3 be be VB cord-015306-us58wwmp 1706 4 the the DT cord-015306-us58wwmp 1706 5 adaptive adaptive JJ cord-015306-us58wwmp 1706 6 cytoprotective cytoprotective JJ cord-015306-us58wwmp 1706 7 mechanism mechanism NN cord-015306-us58wwmp 1706 8 for for IN cord-015306-us58wwmp 1706 9 podocytes podocyte NNS cord-015306-us58wwmp 1706 10 under under IN cord-015306-us58wwmp 1706 11 oxidative oxidative JJ cord-015306-us58wwmp 1706 12 stress stress NN cord-015306-us58wwmp 1706 13 . . . cord-015306-us58wwmp 1707 1 Further further JJ cord-015306-us58wwmp 1707 2 studies study NNS cord-015306-us58wwmp 1707 3 directed direct VBN cord-015306-us58wwmp 1707 4 at at IN cord-015306-us58wwmp 1707 5 identifying identify VBG cord-015306-us58wwmp 1707 6 the the DT cord-015306-us58wwmp 1707 7 role role NN cord-015306-us58wwmp 1707 8 of of IN cord-015306-us58wwmp 1707 9 mTOR mTOR NNP cord-015306-us58wwmp 1707 10 are be VBP cord-015306-us58wwmp 1707 11 essential essential JJ cord-015306-us58wwmp 1707 12 . . . cord-015306-us58wwmp 1708 1 Abstract abstract JJ cord-015306-us58wwmp 1708 2 # # NN cord-015306-us58wwmp 1709 1 P p NN cord-015306-us58wwmp 1709 2 - - HYPH cord-015306-us58wwmp 1709 3 SAT210 SAT210 NNP cord-015306-us58wwmp 1709 4 Impact Impact NNP cord-015306-us58wwmp 1709 5 of of IN cord-015306-us58wwmp 1709 6 Angptl3 Angptl3 NNP cord-015306-us58wwmp 1709 7 knock knock VB cord-015306-us58wwmp 1709 8 - - HYPH cord-015306-us58wwmp 1709 9 out out NN cord-015306-us58wwmp 1709 10 on on IN cord-015306-us58wwmp 1709 11 adriamycin adriamycin NN cord-015306-us58wwmp 1709 12 - - HYPH cord-015306-us58wwmp 1709 13 induced induce VBN cord-015306-us58wwmp 1709 14 nephropathy nephropathy NN cord-015306-us58wwmp 1710 1 mice mice NNP cord-015306-us58wwmp 1710 2 Objective Objective NNP cord-015306-us58wwmp 1710 3 : : : cord-015306-us58wwmp 1711 1 Idiopathic idiopathic JJ cord-015306-us58wwmp 1711 2 focal focal JJ cord-015306-us58wwmp 1711 3 segmental segmental JJ cord-015306-us58wwmp 1711 4 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 1711 5 ( ( -LRB- cord-015306-us58wwmp 1711 6 FSGS FSGS NNP cord-015306-us58wwmp 1711 7 ) ) -RRB- cord-015306-us58wwmp 1711 8 is be VBZ cord-015306-us58wwmp 1711 9 associated associate VBN cord-015306-us58wwmp 1711 10 with with IN cord-015306-us58wwmp 1711 11 recurrence recurrence NN cord-015306-us58wwmp 1711 12 after after IN cord-015306-us58wwmp 1711 13 transplantation transplantation NN cord-015306-us58wwmp 1711 14 due due IN cord-015306-us58wwmp 1711 15 to to IN cord-015306-us58wwmp 1711 16 a a DT cord-015306-us58wwmp 1711 17 circulating circulate VBG cord-015306-us58wwmp 1711 18 permeability permeability NN cord-015306-us58wwmp 1711 19 factor factor NN cord-015306-us58wwmp 1711 20 or or CC cord-015306-us58wwmp 1711 21 factors factor NNS cord-015306-us58wwmp 1711 22 ( ( -LRB- cord-015306-us58wwmp 1711 23 N N NNP cord-015306-us58wwmp 1711 24 Engl Engl NNP cord-015306-us58wwmp 1711 25 J J NNP cord-015306-us58wwmp 1711 26 Med Med NNP cord-015306-us58wwmp 1711 27 , , , cord-015306-us58wwmp 1711 28 334:878 334:878 CD cord-015306-us58wwmp 1711 29 - - SYM cord-015306-us58wwmp 1711 30 883 883 CD cord-015306-us58wwmp 1711 31 , , , cord-015306-us58wwmp 1711 32 1996 1996 CD cord-015306-us58wwmp 1711 33 ) ) -RRB- cord-015306-us58wwmp 1711 34 . . . cord-015306-us58wwmp 1712 1 We -PRON- PRP cord-015306-us58wwmp 1712 2 have have VBP cord-015306-us58wwmp 1712 3 shown show VBN cord-015306-us58wwmp 1712 4 the the DT cord-015306-us58wwmp 1712 5 effects effect NNS cord-015306-us58wwmp 1712 6 of of IN cord-015306-us58wwmp 1712 7 FSGS fsgs NN cord-015306-us58wwmp 1712 8 plasma plasma NN cord-015306-us58wwmp 1712 9 and and CC cord-015306-us58wwmp 1712 10 its -PRON- PRP$ cord-015306-us58wwmp 1712 11 fractions fraction NNS cord-015306-us58wwmp 1712 12 on on IN cord-015306-us58wwmp 1712 13 glomerular glomerular JJ cord-015306-us58wwmp 1712 14 permeability permeability NN cord-015306-us58wwmp 1712 15 in in IN cord-015306-us58wwmp 1712 16 vitro vitro FW cord-015306-us58wwmp 1712 17 and and CC cord-015306-us58wwmp 1712 18 in in IN cord-015306-us58wwmp 1712 19 vivo vivo NN cord-015306-us58wwmp 1712 20 and and CC cord-015306-us58wwmp 1712 21 have have VBP cord-015306-us58wwmp 1712 22 used use VBN cord-015306-us58wwmp 1712 23 state state NN cord-015306-us58wwmp 1712 24 - - HYPH cord-015306-us58wwmp 1712 25 of of IN cord-015306-us58wwmp 1712 26 - - HYPH cord-015306-us58wwmp 1712 27 the the DT cord-015306-us58wwmp 1712 28 - - HYPH cord-015306-us58wwmp 1712 29 art art NN cord-015306-us58wwmp 1712 30 proteomics proteomic NNS cord-015306-us58wwmp 1712 31 to to TO cord-015306-us58wwmp 1712 32 identify identify VB cord-015306-us58wwmp 1712 33 cardiotrophin cardiotrophin NNP cord-015306-us58wwmp 1712 34 - - HYPH cord-015306-us58wwmp 1712 35 like like JJ cord-015306-us58wwmp 1712 36 cytokine-1 cytokine-1 NNP cord-015306-us58wwmp 1712 37 ( ( -LRB- cord-015306-us58wwmp 1712 38 CLCF1 CLCF1 NNP cord-015306-us58wwmp 1712 39 ) ) -RRB- cord-015306-us58wwmp 1712 40 , , , cord-015306-us58wwmp 1712 41 a a DT cord-015306-us58wwmp 1712 42 member member NN cord-015306-us58wwmp 1712 43 of of IN cord-015306-us58wwmp 1712 44 the the DT cord-015306-us58wwmp 1712 45 IL-6 IL-6 NNP cord-015306-us58wwmp 1712 46 family family NN cord-015306-us58wwmp 1712 47 , , , cord-015306-us58wwmp 1712 48 as as IN cord-015306-us58wwmp 1712 49 a a DT cord-015306-us58wwmp 1712 50 candidate candidate NN cord-015306-us58wwmp 1712 51 for for IN cord-015306-us58wwmp 1712 52 the the DT cord-015306-us58wwmp 1712 53 active active JJ cord-015306-us58wwmp 1712 54 substance substance NN cord-015306-us58wwmp 1712 55 . . . cord-015306-us58wwmp 1713 1 We -PRON- PRP cord-015306-us58wwmp 1713 2 hypothesize hypothesize VBP cord-015306-us58wwmp 1713 3 that that IN cord-015306-us58wwmp 1713 4 a a DT cord-015306-us58wwmp 1713 5 new new JJ cord-015306-us58wwmp 1713 6 model model NN cord-015306-us58wwmp 1713 7 of of IN cord-015306-us58wwmp 1713 8 FSGS FSGS NNP cord-015306-us58wwmp 1713 9 can can MD cord-015306-us58wwmp 1713 10 be be VB cord-015306-us58wwmp 1713 11 based base VBN cord-015306-us58wwmp 1713 12 on on IN cord-015306-us58wwmp 1713 13 the the DT cord-015306-us58wwmp 1713 14 effects effect NNS cord-015306-us58wwmp 1713 15 of of IN cord-015306-us58wwmp 1713 16 CLCF1 CLCF1 NNS cord-015306-us58wwmp 1713 17 in in IN cord-015306-us58wwmp 1713 18 mice mouse NNS cord-015306-us58wwmp 1713 19 . . . cord-015306-us58wwmp 1714 1 Methods method NNS cord-015306-us58wwmp 1714 2 : : : cord-015306-us58wwmp 1715 1 rCLCF1 rCLCF1 NNP cord-015306-us58wwmp 1715 2 ( ( -LRB- cord-015306-us58wwmp 1715 3 R&D R&D NNP cord-015306-us58wwmp 1715 4 Systems Systems NNP cord-015306-us58wwmp 1715 5 ) ) -RRB- cord-015306-us58wwmp 1715 6 was be VBD cord-015306-us58wwmp 1715 7 injected inject VBN cord-015306-us58wwmp 1715 8 intraperitoneally intraperitoneally RB cord-015306-us58wwmp 1715 9 ( ( -LRB- cord-015306-us58wwmp 1715 10 IP IP NNP cord-015306-us58wwmp 1715 11 ) ) -RRB- cord-015306-us58wwmp 1715 12 , , , cord-015306-us58wwmp 1715 13 one one CD cord-015306-us58wwmp 1715 14 dose dose NN cord-015306-us58wwmp 1715 15 , , , cord-015306-us58wwmp 1715 16 10 10 CD cord-015306-us58wwmp 1715 17 μg μg NN cord-015306-us58wwmp 1715 18 / / SYM cord-015306-us58wwmp 1715 19 kg kg NNP cord-015306-us58wwmp 1715 20 , , , cord-015306-us58wwmp 1715 21 or or CC cord-015306-us58wwmp 1715 22 infused infuse VBN cord-015306-us58wwmp 1715 23 by by IN cord-015306-us58wwmp 1715 24 minipump minipump NNP cord-015306-us58wwmp 1715 25 for for IN cord-015306-us58wwmp 1715 26 28 28 CD cord-015306-us58wwmp 1715 27 days day NNS cord-015306-us58wwmp 1715 28 , , , cord-015306-us58wwmp 1715 29 40 40 CD cord-015306-us58wwmp 1715 30 μg μg NN cord-015306-us58wwmp 1715 31 /kg /kg NNP cord-015306-us58wwmp 1715 32 / / SYM cord-015306-us58wwmp 1715 33 day day NN cord-015306-us58wwmp 1715 34 . . . cord-015306-us58wwmp 1716 1 A a DT cord-015306-us58wwmp 1716 2 construct construct NN cord-015306-us58wwmp 1716 3 containing contain VBG cord-015306-us58wwmp 1716 4 CLCF-1 CLCF-1 NNP cord-015306-us58wwmp 1716 5 was be VBD cord-015306-us58wwmp 1716 6 administered administer VBN cord-015306-us58wwmp 1716 7 by by IN cord-015306-us58wwmp 1716 8 electroporation electroporation NN cord-015306-us58wwmp 1716 9 . . . cord-015306-us58wwmp 1717 1 All all DT cord-015306-us58wwmp 1717 2 studies study NNS cord-015306-us58wwmp 1717 3 were be VBD cord-015306-us58wwmp 1717 4 done do VBN cord-015306-us58wwmp 1717 5 in in IN cord-015306-us58wwmp 1717 6 C57BL6 C57BL6 NNP cord-015306-us58wwmp 1717 7 mice mouse NNS cord-015306-us58wwmp 1717 8 . . . cord-015306-us58wwmp 1718 1 Urinary urinary JJ cord-015306-us58wwmp 1718 2 albumin albumin NN cord-015306-us58wwmp 1718 3 / / SYM cord-015306-us58wwmp 1718 4 creatinine creatinine NN cord-015306-us58wwmp 1718 5 , , , cord-015306-us58wwmp 1718 6 pJAK1 pJAK1 NNP cord-015306-us58wwmp 1718 7 , , , cord-015306-us58wwmp 1718 8 pSTAT3 pstat3 CD cord-015306-us58wwmp 1718 9 , , , cord-015306-us58wwmp 1718 10 pATK patk JJ cord-015306-us58wwmp 1718 11 , , , cord-015306-us58wwmp 1718 12 and and CC cord-015306-us58wwmp 1718 13 pERK pERK NNP cord-015306-us58wwmp 1719 1 in in IN cord-015306-us58wwmp 1719 2 peripheral peripheral JJ cord-015306-us58wwmp 1719 3 blood blood NN cord-015306-us58wwmp 1719 4 cells cell NNS cord-015306-us58wwmp 1719 5 ( ( -LRB- cord-015306-us58wwmp 1719 6 PBC PBC NNP cord-015306-us58wwmp 1719 7 ) ) -RRB- cord-015306-us58wwmp 1719 8 and and CC cord-015306-us58wwmp 1719 9 in in IN cord-015306-us58wwmp 1719 10 kidney kidney NN cord-015306-us58wwmp 1719 11 homogenate homogenate NNP cord-015306-us58wwmp 1719 12 were be VBD cord-015306-us58wwmp 1719 13 measured measure VBN cord-015306-us58wwmp 1719 14 and and CC cord-015306-us58wwmp 1719 15 glomerular glomerular JJ cord-015306-us58wwmp 1719 16 histology histology NN cord-015306-us58wwmp 1719 17 was be VBD cord-015306-us58wwmp 1719 18 assessed assess VBN cord-015306-us58wwmp 1719 19 . . . cord-015306-us58wwmp 1720 1 Results result NNS cord-015306-us58wwmp 1720 2 : : : cord-015306-us58wwmp 1721 1 Albuminuria Albuminuria NNP cord-015306-us58wwmp 1721 2 was be VBD cord-015306-us58wwmp 1721 3 induced induce VBN cord-015306-us58wwmp 1721 4 promptly promptly RB cord-015306-us58wwmp 1721 5 by by IN cord-015306-us58wwmp 1721 6 rCLCF1 rCLCF1 NNS cord-015306-us58wwmp 1721 7 after after IN cord-015306-us58wwmp 1721 8 either either DT cord-015306-us58wwmp 1721 9 injection injection NN cord-015306-us58wwmp 1721 10 or or CC cord-015306-us58wwmp 1721 11 electroporation electroporation NN cord-015306-us58wwmp 1721 12 . . . cord-015306-us58wwmp 1722 1 Peak Peak NNP cord-015306-us58wwmp 1722 2 albuminuria albuminuria NNS cord-015306-us58wwmp 1722 3 occurred occur VBD cord-015306-us58wwmp 1722 4 by by IN cord-015306-us58wwmp 1722 5 7 7 CD cord-015306-us58wwmp 1722 6 days day NNS cord-015306-us58wwmp 1722 7 of of IN cord-015306-us58wwmp 1722 8 expression expression NN cord-015306-us58wwmp 1722 9 and and CC cord-015306-us58wwmp 1722 10 was be VBD cord-015306-us58wwmp 1722 11 3 3 CD cord-015306-us58wwmp 1722 12 - - SYM cord-015306-us58wwmp 1722 13 5 5 CD cord-015306-us58wwmp 1722 14 fold fold NN cord-015306-us58wwmp 1722 15 increased increase VBN cord-015306-us58wwmp 1722 16 vs. vs. IN cord-015306-us58wwmp 1722 17 baseline baseline NN cord-015306-us58wwmp 1722 18 . . . cord-015306-us58wwmp 1723 1 IP IP NNP cord-015306-us58wwmp 1723 2 administration administration NN cord-015306-us58wwmp 1723 3 of of IN cord-015306-us58wwmp 1723 4 rCLCF-1 rCLCF-1 NNP cord-015306-us58wwmp 1723 5 increased increase VBD cord-015306-us58wwmp 1723 6 pJAK2 pjak2 NN cord-015306-us58wwmp 1723 7 and and CC cord-015306-us58wwmp 1723 8 pSTAT3 pstat3 CD cord-015306-us58wwmp 1723 9 of of IN cord-015306-us58wwmp 1723 10 PBC PBC NNP cord-015306-us58wwmp 1723 11 within within IN cord-015306-us58wwmp 1723 12 15 15 CD cord-015306-us58wwmp 1723 13 min min NN cord-015306-us58wwmp 1723 14 . . . cord-015306-us58wwmp 1724 1 and and CC cord-015306-us58wwmp 1724 2 renal renal NNP cord-015306-us58wwmp 1724 3 pJAK1 pJAK1 NNP cord-015306-us58wwmp 1724 4 and and CC cord-015306-us58wwmp 1724 5 pSTAT3 pSTAT3 NNP cord-015306-us58wwmp 1724 6 remained remain VBD cord-015306-us58wwmp 1724 7 upregulated upregulate VBN cord-015306-us58wwmp 1724 8 for for IN cord-015306-us58wwmp 1724 9 at at RB cord-015306-us58wwmp 1724 10 least least RBS cord-015306-us58wwmp 1724 11 72 72 CD cord-015306-us58wwmp 1724 12 hours hour NNS cord-015306-us58wwmp 1724 13 after after IN cord-015306-us58wwmp 1724 14 injection injection NN cord-015306-us58wwmp 1724 15 . . . cord-015306-us58wwmp 1725 1 Kidney kidney NN cord-015306-us58wwmp 1725 2 pJAK2 pjak2 NN cord-015306-us58wwmp 1725 3 and and CC cord-015306-us58wwmp 1725 4 pSTAT3 pstat3 NN cord-015306-us58wwmp 1725 5 as as RB cord-015306-us58wwmp 1725 6 well well RB cord-015306-us58wwmp 1725 7 as as IN cord-015306-us58wwmp 1725 8 pERK/12 pERK/12 NNP cord-015306-us58wwmp 1725 9 and and CC cord-015306-us58wwmp 1725 10 pAKT pakt NN cord-015306-us58wwmp 1725 11 were be VBD cord-015306-us58wwmp 1725 12 markedly markedly RB cord-015306-us58wwmp 1725 13 increased increase VBN cord-015306-us58wwmp 1725 14 after after IN cord-015306-us58wwmp 1725 15 28 28 CD cord-015306-us58wwmp 1725 16 days day NNS cord-015306-us58wwmp 1725 17 of of IN cord-015306-us58wwmp 1725 18 infusion infusion NN cord-015306-us58wwmp 1725 19 . . . cord-015306-us58wwmp 1726 1 Mesangial mesangial JJ cord-015306-us58wwmp 1726 2 matrix matrix NN cord-015306-us58wwmp 1726 3 was be VBD cord-015306-us58wwmp 1726 4 increased increase VBN cord-015306-us58wwmp 1726 5 at at IN cord-015306-us58wwmp 1726 6 that that DT cord-015306-us58wwmp 1726 7 time time NN cord-015306-us58wwmp 1726 8 . . . cord-015306-us58wwmp 1727 1 Conclusion conclusion NN cord-015306-us58wwmp 1727 2 : : : cord-015306-us58wwmp 1728 1 We -PRON- PRP cord-015306-us58wwmp 1728 2 conclude conclude VBP cord-015306-us58wwmp 1728 3 that that IN cord-015306-us58wwmp 1728 4 CLCF1 CLCF1 NNP cord-015306-us58wwmp 1728 5 mimics mimic VBZ cord-015306-us58wwmp 1728 6 many many JJ cord-015306-us58wwmp 1728 7 of of IN cord-015306-us58wwmp 1728 8 the the DT cord-015306-us58wwmp 1728 9 renal renal JJ cord-015306-us58wwmp 1728 10 effects effect NNS cord-015306-us58wwmp 1728 11 of of IN cord-015306-us58wwmp 1728 12 the the DT cord-015306-us58wwmp 1728 13 active active JJ cord-015306-us58wwmp 1728 14 fraction fraction NN cord-015306-us58wwmp 1728 15 of of IN cord-015306-us58wwmp 1728 16 plasma plasma NN cord-015306-us58wwmp 1728 17 from from IN cord-015306-us58wwmp 1728 18 patients patient NNS cord-015306-us58wwmp 1728 19 with with IN cord-015306-us58wwmp 1728 20 idiopathic idiopathic JJ cord-015306-us58wwmp 1728 21 FSGS FSGS NNP cord-015306-us58wwmp 1728 22 and and CC cord-015306-us58wwmp 1728 23 may may MD cord-015306-us58wwmp 1728 24 play play VB cord-015306-us58wwmp 1728 25 an an DT cord-015306-us58wwmp 1728 26 important important JJ cord-015306-us58wwmp 1728 27 role role NN cord-015306-us58wwmp 1728 28 in in IN cord-015306-us58wwmp 1728 29 its -PRON- PRP$ cord-015306-us58wwmp 1728 30 etiology etiology NN cord-015306-us58wwmp 1728 31 . . . cord-015306-us58wwmp 1729 1 Its -PRON- PRP$ cord-015306-us58wwmp 1729 2 relationship relationship NN cord-015306-us58wwmp 1729 3 to to IN cord-015306-us58wwmp 1729 4 other other JJ cord-015306-us58wwmp 1729 5 candidates candidate NNS cord-015306-us58wwmp 1729 6 such such JJ cord-015306-us58wwmp 1729 7 as as IN cord-015306-us58wwmp 1729 8 circulating circulate VBG cord-015306-us58wwmp 1729 9 urokinase urokinase NN cord-015306-us58wwmp 1729 10 receptor receptor NN cord-015306-us58wwmp 1729 11 ( ( -LRB- cord-015306-us58wwmp 1729 12 suPAR supar NN cord-015306-us58wwmp 1729 13 ) ) -RRB- cord-015306-us58wwmp 1729 14 is be VBZ cord-015306-us58wwmp 1729 15 not not RB cord-015306-us58wwmp 1729 16 known know VBN cord-015306-us58wwmp 1729 17 . . . cord-015306-us58wwmp 1730 1 A a DT cord-015306-us58wwmp 1730 2 murine murine JJ cord-015306-us58wwmp 1730 3 model model NN cord-015306-us58wwmp 1730 4 based base VBN cord-015306-us58wwmp 1730 5 on on IN cord-015306-us58wwmp 1730 6 administration administration NN cord-015306-us58wwmp 1730 7 or or CC cord-015306-us58wwmp 1730 8 overexpression overexpression NN cord-015306-us58wwmp 1730 9 of of IN cord-015306-us58wwmp 1730 10 CLCF1 CLCF1 NNPS cord-015306-us58wwmp 1730 11 may may MD cord-015306-us58wwmp 1730 12 permit permit VB cord-015306-us58wwmp 1730 13 us -PRON- PRP cord-015306-us58wwmp 1730 14 to to TO cord-015306-us58wwmp 1730 15 define define VB cord-015306-us58wwmp 1730 16 mechanisms mechanism NNS cord-015306-us58wwmp 1730 17 of of IN cord-015306-us58wwmp 1730 18 injury injury NN cord-015306-us58wwmp 1730 19 and and CC cord-015306-us58wwmp 1730 20 to to TO cord-015306-us58wwmp 1730 21 test test VB cord-015306-us58wwmp 1730 22 potential potential JJ cord-015306-us58wwmp 1730 23 therapeutic therapeutic JJ cord-015306-us58wwmp 1730 24 agents agent NNS cord-015306-us58wwmp 1730 25 prior prior RB cord-015306-us58wwmp 1730 26 to to IN cord-015306-us58wwmp 1730 27 use use NN cord-015306-us58wwmp 1730 28 in in IN cord-015306-us58wwmp 1730 29 clinical clinical JJ cord-015306-us58wwmp 1730 30 trials trial NNS cord-015306-us58wwmp 1730 31 . . . cord-015306-us58wwmp 1731 1 Over over IN cord-015306-us58wwmp 1731 2 - - HYPH cord-015306-us58wwmp 1731 3 expression expression NN cord-015306-us58wwmp 1731 4 of of IN cord-015306-us58wwmp 1731 5 Myo1e Myo1e NNP cord-015306-us58wwmp 1731 6 in in IN cord-015306-us58wwmp 1731 7 mouse mouse NN cord-015306-us58wwmp 1731 8 podocytes podocyte NNS cord-015306-us58wwmp 1731 9 enhance enhance VBP cord-015306-us58wwmp 1731 10 cellular cellular JJ cord-015306-us58wwmp 1731 11 endocytosis endocytosis NN cord-015306-us58wwmp 1731 12 , , , cord-015306-us58wwmp 1731 13 migration migration NN cord-015306-us58wwmp 1731 14 , , , cord-015306-us58wwmp 1731 15 and and CC cord-015306-us58wwmp 1731 16 adhesion adhesion NN cord-015306-us58wwmp 1731 17 Objective objective NN cord-015306-us58wwmp 1731 18 : : : cord-015306-us58wwmp 1732 1 To to TO cord-015306-us58wwmp 1732 2 investigate investigate VB cord-015306-us58wwmp 1732 3 the the DT cord-015306-us58wwmp 1732 4 effects effect NNS cord-015306-us58wwmp 1732 5 of of IN cord-015306-us58wwmp 1732 6 tacrolimus tacrolimus NN cord-015306-us58wwmp 1732 7 ( ( -LRB- cord-015306-us58wwmp 1732 8 FK506 FK506 NNP cord-015306-us58wwmp 1732 9 ) ) -RRB- cord-015306-us58wwmp 1732 10 on on IN cord-015306-us58wwmp 1732 11 hepatocyte hepatocyte NN cord-015306-us58wwmp 1732 12 growth growth NN cord-015306-us58wwmp 1732 13 factor factor NN cord-015306-us58wwmp 1732 14 and and CC cord-015306-us58wwmp 1732 15 transforming transform VBG cord-015306-us58wwmp 1732 16 growth growth NN cord-015306-us58wwmp 1732 17 factor factor NN cord-015306-us58wwmp 1732 18 β1 β1 NNP cord-015306-us58wwmp 1732 19 in in IN cord-015306-us58wwmp 1732 20 kidneys kidney NNS cord-015306-us58wwmp 1732 21 of of IN cord-015306-us58wwmp 1732 22 FSGS FSGS NNP cord-015306-us58wwmp 1732 23 rats rat NNS cord-015306-us58wwmp 1732 24 . . . cord-015306-us58wwmp 1733 1 Methods method NNS cord-015306-us58wwmp 1733 2 : : : cord-015306-us58wwmp 1733 3 Establish establish VB cord-015306-us58wwmp 1733 4 unilateral unilateral JJ cord-015306-us58wwmp 1733 5 nephrectomy nephrectomy NN cord-015306-us58wwmp 1733 6 combined combine VBN cord-015306-us58wwmp 1734 1 adriamycin adriamycin IN cord-015306-us58wwmp 1734 2 double double JJ cord-015306-us58wwmp 1734 3 tail tail NN cord-015306-us58wwmp 1734 4 vein vein NN cord-015306-us58wwmp 1734 5 injection injection NN cord-015306-us58wwmp 1734 6 of of IN cord-015306-us58wwmp 1734 7 FSGS FSGS NNP cord-015306-us58wwmp 1734 8 model model NN cord-015306-us58wwmp 1734 9 in in IN cord-015306-us58wwmp 1734 10 rats rat NNS cord-015306-us58wwmp 1734 11 divided divide VBN cord-015306-us58wwmp 1734 12 to to TO cord-015306-us58wwmp 1734 13 model model VB cord-015306-us58wwmp 1734 14 group group NN cord-015306-us58wwmp 1734 15 and and CC cord-015306-us58wwmp 1734 16 treatment treatment NN cord-015306-us58wwmp 1734 17 group group NN cord-015306-us58wwmp 1734 18 , , , cord-015306-us58wwmp 1734 19 then then RB cord-015306-us58wwmp 1734 20 treatment treatment NN cord-015306-us58wwmp 1734 21 group group NN cord-015306-us58wwmp 1734 22 rats rat NNS cord-015306-us58wwmp 1734 23 were be VBD cord-015306-us58wwmp 1734 24 treated treat VBN cord-015306-us58wwmp 1734 25 withtacrolimus withtacrolimus JJ cord-015306-us58wwmp 1734 26 8 8 CD cord-015306-us58wwmp 1734 27 weeks week NNS cord-015306-us58wwmp 1734 28 . . . cord-015306-us58wwmp 1735 1 The the DT cord-015306-us58wwmp 1735 2 protein protein NN cord-015306-us58wwmp 1735 3 expression expression NN cord-015306-us58wwmp 1735 4 and and CC cord-015306-us58wwmp 1735 5 site site NN cord-015306-us58wwmp 1735 6 of of IN cord-015306-us58wwmp 1735 7 HGF HGF NNP cord-015306-us58wwmp 1735 8 and and CC cord-015306-us58wwmp 1735 9 TGF TGF NNP cord-015306-us58wwmp 1735 10 - - HYPH cord-015306-us58wwmp 1735 11 β1 β1 NNP cord-015306-us58wwmp 1735 12 in in IN cord-015306-us58wwmp 1735 13 renal renal NN cord-015306-us58wwmp 1735 14 of of IN cord-015306-us58wwmp 1735 15 each each DT cord-015306-us58wwmp 1735 16 group group NN cord-015306-us58wwmp 1735 17 were be VBD cord-015306-us58wwmp 1735 18 assayed assay VBN cord-015306-us58wwmp 1735 19 by by IN cord-015306-us58wwmp 1735 20 Western western JJ cord-015306-us58wwmp 1735 21 blot blot NN cord-015306-us58wwmp 1735 22 and and CC cord-015306-us58wwmp 1735 23 immunohistochemistry immunohistochemistry NN cord-015306-us58wwmp 1735 24 after after IN cord-015306-us58wwmp 1735 25 animals animal NNS cord-015306-us58wwmp 1735 26 were be VBD cord-015306-us58wwmp 1735 27 sacrificed sacrifice VBN cord-015306-us58wwmp 1735 28 . . . cord-015306-us58wwmp 1736 1 Urine urine NN cord-015306-us58wwmp 1736 2 protein protein NN cord-015306-us58wwmp 1736 3 , , , cord-015306-us58wwmp 1736 4 serum serum NN cord-015306-us58wwmp 1736 5 albumin albumin NN cord-015306-us58wwmp 1736 6 , , , cord-015306-us58wwmp 1736 7 blood blood NN cord-015306-us58wwmp 1736 8 lipoids lipoid NNS cord-015306-us58wwmp 1736 9 and and CC cord-015306-us58wwmp 1736 10 kidney kidney NN cord-015306-us58wwmp 1736 11 function function NN cord-015306-us58wwmp 1736 12 were be VBD cord-015306-us58wwmp 1736 13 tested test VBN cord-015306-us58wwmp 1736 14 automatic automatic JJ cord-015306-us58wwmp 1736 15 biochemical biochemical JJ cord-015306-us58wwmp 1736 16 analysis analysis NN cord-015306-us58wwmp 1736 17 system system NN cord-015306-us58wwmp 1736 18 . . . cord-015306-us58wwmp 1737 1 Results result NNS cord-015306-us58wwmp 1738 1 Compared compare VBN cord-015306-us58wwmp 1738 2 with with IN cord-015306-us58wwmp 1738 3 the the DT cord-015306-us58wwmp 1738 4 normal normal JJ cord-015306-us58wwmp 1738 5 control control NN cord-015306-us58wwmp 1738 6 group group NN cord-015306-us58wwmp 1738 7 , , , cord-015306-us58wwmp 1738 8 model model NN cord-015306-us58wwmp 1738 9 group group NN cord-015306-us58wwmp 1738 10 and and CC cord-015306-us58wwmp 1738 11 treatment treatment NN cord-015306-us58wwmp 1738 12 group group NN cord-015306-us58wwmp 1738 13 rats rat NNS cord-015306-us58wwmp 1738 14 24h 24h VBD cord-015306-us58wwmp 1738 15 urinary urinary JJ cord-015306-us58wwmp 1738 16 protein protein NN cord-015306-us58wwmp 1738 17 excretion excretion NN cord-015306-us58wwmp 1738 18 , , , cord-015306-us58wwmp 1738 19 serum serum NN cord-015306-us58wwmp 1738 20 creatinine creatinine NN cord-015306-us58wwmp 1738 21 , , , cord-015306-us58wwmp 1738 22 blood blood NN cord-015306-us58wwmp 1738 23 urea urea NN cord-015306-us58wwmp 1738 24 nitrogen nitrogen NN cord-015306-us58wwmp 1738 25 , , , cord-015306-us58wwmp 1738 26 cholesterol cholesterol NN cord-015306-us58wwmp 1738 27 significantly significantly RB cord-015306-us58wwmp 1738 28 increased increase VBD cord-015306-us58wwmp 1739 1 serum serum NN cord-015306-us58wwmp 1739 2 albumin albumin NN cord-015306-us58wwmp 1739 3 significantly significantly RB cord-015306-us58wwmp 1739 4 reduced reduce VBD cord-015306-us58wwmp 1739 5 severe severe JJ cord-015306-us58wwmp 1739 6 renal renal JJ cord-015306-us58wwmp 1739 7 pathological pathological JJ cord-015306-us58wwmp 1739 8 changes change NNS cord-015306-us58wwmp 1739 9 and and CC cord-015306-us58wwmp 1739 10 TGF TGF NNP cord-015306-us58wwmp 1739 11 - - HYPH cord-015306-us58wwmp 1739 12 β1 β1 NNP cord-015306-us58wwmp 1739 13 protein protein NN cord-015306-us58wwmp 1739 14 expression expression NN cord-015306-us58wwmp 1739 15 was be VBD cord-015306-us58wwmp 1739 16 significantly significantly RB cord-015306-us58wwmp 1739 17 increased increase VBN cord-015306-us58wwmp 1739 18 , , , cord-015306-us58wwmp 1739 19 and and CC cord-015306-us58wwmp 1739 20 the the DT cord-015306-us58wwmp 1739 21 differences difference NNS cord-015306-us58wwmp 1739 22 were be VBD cord-015306-us58wwmp 1739 23 statistically statistically RB cord-015306-us58wwmp 1739 24 significant significant JJ cord-015306-us58wwmp 1739 25 ( ( -LRB- cord-015306-us58wwmp 1739 26 P p NN cord-015306-us58wwmp 1739 27 < < XX cord-015306-us58wwmp 1739 28 0.05 0.05 CD cord-015306-us58wwmp 1739 29 ) ) -RRB- cord-015306-us58wwmp 1739 30 ; ; : cord-015306-us58wwmp 1739 31 compared compare VBN cord-015306-us58wwmp 1739 32 with with IN cord-015306-us58wwmp 1739 33 the the DT cord-015306-us58wwmp 1739 34 model model NN cord-015306-us58wwmp 1739 35 group group NN cord-015306-us58wwmp 1739 36 , , , cord-015306-us58wwmp 1739 37 in in IN cord-015306-us58wwmp 1739 38 experiments experiment NNS cord-015306-us58wwmp 1739 39 9 9 CD cord-015306-us58wwmp 1739 40 weekend weekend NN cord-015306-us58wwmp 1739 41 , , , cord-015306-us58wwmp 1739 42 the the DT cord-015306-us58wwmp 1739 43 treated treat VBN cord-015306-us58wwmp 1739 44 rats rat NNS cord-015306-us58wwmp 1739 45 24h 24h CC cord-015306-us58wwmp 1739 46 urinary urinary JJ cord-015306-us58wwmp 1739 47 protein protein NN cord-015306-us58wwmp 1739 48 excretion excretion NN cord-015306-us58wwmp 1739 49 , , , cord-015306-us58wwmp 1739 50 relevant relevant JJ cord-015306-us58wwmp 1739 51 serum serum NN cord-015306-us58wwmp 1739 52 biochemical biochemical JJ cord-015306-us58wwmp 1739 53 indicators indicator NNS cord-015306-us58wwmp 1739 54 of of IN cord-015306-us58wwmp 1739 55 renal renal JJ cord-015306-us58wwmp 1739 56 pathological pathological JJ cord-015306-us58wwmp 1739 57 changes change NNS cord-015306-us58wwmp 1739 58 varying vary VBG cord-015306-us58wwmp 1739 59 degree degree NN cord-015306-us58wwmp 1739 60 of of IN cord-015306-us58wwmp 1739 61 improvement improvement NN cord-015306-us58wwmp 1739 62 in in IN cord-015306-us58wwmp 1739 63 renal renal JJ cord-015306-us58wwmp 1739 64 tissue tissue NN cord-015306-us58wwmp 1739 65 HGF hgf NN cord-015306-us58wwmp 1739 66 protein protein NN cord-015306-us58wwmp 1739 67 expression expression NN cord-015306-us58wwmp 1739 68 was be VBD cord-015306-us58wwmp 1739 69 increased increase VBN cord-015306-us58wwmp 1739 70 and and CC cord-015306-us58wwmp 1739 71 TGF TGF NNP cord-015306-us58wwmp 1739 72 - - HYPH cord-015306-us58wwmp 1739 73 β1 β1 NNP cord-015306-us58wwmp 1739 74 protein protein NN cord-015306-us58wwmp 1739 75 expression expression NN cord-015306-us58wwmp 1739 76 was be VBD cord-015306-us58wwmp 1739 77 decreased decrease VBN cord-015306-us58wwmp 1739 78 , , , cord-015306-us58wwmp 1739 79 the the DT cord-015306-us58wwmp 1739 80 above above JJ cord-015306-us58wwmp 1739 81 differences difference NNS cord-015306-us58wwmp 1739 82 were be VBD cord-015306-us58wwmp 1739 83 statistically statistically RB cord-015306-us58wwmp 1739 84 significant significant JJ cord-015306-us58wwmp 1739 85 ( ( -LRB- cord-015306-us58wwmp 1739 86 P p NN cord-015306-us58wwmp 1739 87 < < XX cord-015306-us58wwmp 1739 88 0.05 0.05 CD cord-015306-us58wwmp 1739 89 ) ) -RRB- cord-015306-us58wwmp 1739 90 . . . cord-015306-us58wwmp 1740 1 Objective objective NN cord-015306-us58wwmp 1740 2 : : : cord-015306-us58wwmp 1741 1 The the DT cord-015306-us58wwmp 1741 2 cellular cellular JJ cord-015306-us58wwmp 1741 3 mechanisms mechanism NNS cord-015306-us58wwmp 1741 4 of of IN cord-015306-us58wwmp 1741 5 kidney kidney NN cord-015306-us58wwmp 1741 6 injury injury NN cord-015306-us58wwmp 1741 7 caused cause VBN cord-015306-us58wwmp 1741 8 by by IN cord-015306-us58wwmp 1741 9 obstructive obstructive JJ cord-015306-us58wwmp 1741 10 nephropathy nephropathy NN cord-015306-us58wwmp 1741 11 are be VBP cord-015306-us58wwmp 1741 12 interstitial interstitial JJ cord-015306-us58wwmp 1741 13 inflammation inflammation NN cord-015306-us58wwmp 1741 14 , , , cord-015306-us58wwmp 1741 15 fibrosis fibrosis NN cord-015306-us58wwmp 1741 16 , , , cord-015306-us58wwmp 1741 17 and and CC cord-015306-us58wwmp 1741 18 apoptosis apoptosis NN cord-015306-us58wwmp 1741 19 . . . cord-015306-us58wwmp 1742 1 Rodent rodent NN cord-015306-us58wwmp 1742 2 models model NNS cord-015306-us58wwmp 1742 3 can can MD cord-015306-us58wwmp 1742 4 be be VB cord-015306-us58wwmp 1742 5 used use VBN cord-015306-us58wwmp 1742 6 to to TO cord-015306-us58wwmp 1742 7 simulate simulate VB cord-015306-us58wwmp 1742 8 obstructive obstructive JJ cord-015306-us58wwmp 1742 9 nephropathy nephropathy NN cord-015306-us58wwmp 1742 10 in in IN cord-015306-us58wwmp 1742 11 the the DT cord-015306-us58wwmp 1742 12 human human JJ cord-015306-us58wwmp 1742 13 kidney kidney NN cord-015306-us58wwmp 1742 14 . . . cord-015306-us58wwmp 1743 1 We -PRON- PRP cord-015306-us58wwmp 1743 2 developed develop VBD cord-015306-us58wwmp 1743 3 shear shear NN cord-015306-us58wwmp 1743 4 - - HYPH cord-015306-us58wwmp 1743 5 thinning thin VBG cord-015306-us58wwmp 1743 6 hydrogels hydrogel NNS cord-015306-us58wwmp 1743 7 for for IN cord-015306-us58wwmp 1743 8 the the DT cord-015306-us58wwmp 1743 9 local local JJ cord-015306-us58wwmp 1743 10 delivery delivery NN cord-015306-us58wwmp 1743 11 of of IN cord-015306-us58wwmp 1743 12 IL-10 IL-10 NNP cord-015306-us58wwmp 1743 13 to to TO cord-015306-us58wwmp 1743 14 abate abate VB cord-015306-us58wwmp 1743 15 the the DT cord-015306-us58wwmp 1743 16 progression progression NN cord-015306-us58wwmp 1743 17 of of IN cord-015306-us58wwmp 1743 18 inflammation inflammation NN cord-015306-us58wwmp 1743 19 and and CC cord-015306-us58wwmp 1743 20 fibrosis fibrosis NN cord-015306-us58wwmp 1743 21 that that WDT cord-015306-us58wwmp 1743 22 leads lead VBZ cord-015306-us58wwmp 1743 23 to to IN cord-015306-us58wwmp 1743 24 CKD CKD NNP cord-015306-us58wwmp 1743 25 . . . cord-015306-us58wwmp 1744 1 Methods method NNS cord-015306-us58wwmp 1744 2 : : : cord-015306-us58wwmp 1745 1 Injectable Injectable NNP cord-015306-us58wwmp 1745 2 Dock Dock NNP cord-015306-us58wwmp 1745 3 - - HYPH cord-015306-us58wwmp 1745 4 n n NNP cord-015306-us58wwmp 1745 5 - - HYPH cord-015306-us58wwmp 1745 6 Lock Lock NNP cord-015306-us58wwmp 1745 7 gels gel NNS cord-015306-us58wwmp 1745 8 were be VBD cord-015306-us58wwmp 1745 9 developed develop VBN cord-015306-us58wwmp 1745 10 as as IN cord-015306-us58wwmp 1745 11 previously previously RB cord-015306-us58wwmp 1745 12 reported report VBN cord-015306-us58wwmp 1745 13 1 1 CD cord-015306-us58wwmp 1745 14 ( ( -LRB- cord-015306-us58wwmp 1745 15 Fig fig NN cord-015306-us58wwmp 1745 16 . . . cord-015306-us58wwmp 1745 17 1 1 CD cord-015306-us58wwmp 1745 18 ) ) -RRB- cord-015306-us58wwmp 1745 19 . . . cord-015306-us58wwmp 1745 20 IL-10 IL-10 NNP cord-015306-us58wwmp 1745 21 was be VBD cord-015306-us58wwmp 1745 22 added add VBN cord-015306-us58wwmp 1745 23 to to IN cord-015306-us58wwmp 1745 24 the the DT cord-015306-us58wwmp 1745 25 gel gel NN cord-015306-us58wwmp 1745 26 or or CC cord-015306-us58wwmp 1745 27 phosphate phosphate NN cord-015306-us58wwmp 1745 28 buffered buffer VBN cord-015306-us58wwmp 1745 29 saline saline NN cord-015306-us58wwmp 1745 30 solution solution NN cord-015306-us58wwmp 1745 31 at at IN cord-015306-us58wwmp 1745 32 a a DT cord-015306-us58wwmp 1745 33 concentration concentration NN cord-015306-us58wwmp 1745 34 of of IN cord-015306-us58wwmp 1745 35 0.33 0.33 CD cord-015306-us58wwmp 1745 36 ug ug NNP cord-015306-us58wwmp 1745 37 / / SYM cord-015306-us58wwmp 1745 38 uL. uL. NNP cord-015306-us58wwmp 1745 39 Study Study NNP cord-015306-us58wwmp 1745 40 Design Design NNP cord-015306-us58wwmp 1745 41 : : : cord-015306-us58wwmp 1745 42 Eight eight CD cord-015306-us58wwmp 1745 43 cohorts cohort NNS cord-015306-us58wwmp 1745 44 were be VBD cord-015306-us58wwmp 1745 45 studied study VBN cord-015306-us58wwmp 1745 46 ( ( -LRB- cord-015306-us58wwmp 1745 47 7 7 CD cord-015306-us58wwmp 1745 48 , , , cord-015306-us58wwmp 1745 49 21 21 CD cord-015306-us58wwmp 1745 50 , , , cord-015306-us58wwmp 1745 51 35 35 CD cord-015306-us58wwmp 1745 52 days day NNS cord-015306-us58wwmp 1745 53 , , , cord-015306-us58wwmp 1745 54 n=4 n=4 JJ cord-015306-us58wwmp 1745 55 ) ) -RRB- cord-015306-us58wwmp 1745 56 : : : cord-015306-us58wwmp 1745 57 healthy healthy JJ cord-015306-us58wwmp 1745 58 , , , cord-015306-us58wwmp 1745 59 sham sham JJ cord-015306-us58wwmp 1745 60 operation operation NN cord-015306-us58wwmp 1745 61 , , , cord-015306-us58wwmp 1745 62 healthy healthy JJ cord-015306-us58wwmp 1745 63 injected inject VBN cord-015306-us58wwmp 1745 64 with with IN cord-015306-us58wwmp 1745 65 MSA MSA NNP cord-015306-us58wwmp 1745 66 , , , cord-015306-us58wwmp 1745 67 healthy healthy JJ cord-015306-us58wwmp 1745 68 + + CC cord-015306-us58wwmp 1745 69 gel gel NN cord-015306-us58wwmp 1745 70 , , , cord-015306-us58wwmp 1745 71 unilateral unilateral JJ cord-015306-us58wwmp 1745 72 ureteral ureteral JJ cord-015306-us58wwmp 1745 73 obstruction obstruction NN cord-015306-us58wwmp 1745 74 ( ( -LRB- cord-015306-us58wwmp 1745 75 UUO UUO NNP cord-015306-us58wwmp 1745 76 ) ) -RRB- cord-015306-us58wwmp 1745 77 , , , cord-015306-us58wwmp 1745 78 UUO UUO NNP cord-015306-us58wwmp 1745 79 + + CC cord-015306-us58wwmp 1745 80 IL-10 IL-10 NNP cord-015306-us58wwmp 1745 81 , , , cord-015306-us58wwmp 1745 82 UUO UUO NNP cord-015306-us58wwmp 1745 83 + + CC cord-015306-us58wwmp 1745 84 gel gel NN cord-015306-us58wwmp 1745 85 , , , cord-015306-us58wwmp 1745 86 UUO UUO NNP cord-015306-us58wwmp 1745 87 + + CC cord-015306-us58wwmp 1745 88 gel gel NN cord-015306-us58wwmp 1746 1 /IL-10 /IL-10 NNP cord-015306-us58wwmp 1746 2 . . . cord-015306-us58wwmp 1746 3 15 15 CD cord-015306-us58wwmp 1746 4 uL ul NN cord-015306-us58wwmp 1746 5 of of IN cord-015306-us58wwmp 1746 6 IL-10 IL-10 NNP cord-015306-us58wwmp 1746 7 solution solution NN cord-015306-us58wwmp 1746 8 , , , cord-015306-us58wwmp 1746 9 gel gel NN cord-015306-us58wwmp 1746 10 , , , cord-015306-us58wwmp 1746 11 or or CC cord-015306-us58wwmp 1746 12 gel gel NN cord-015306-us58wwmp 1746 13 / / , cord-015306-us58wwmp 1746 14 IL-10 IL-10 NNP cord-015306-us58wwmp 1746 15 was be VBD cord-015306-us58wwmp 1746 16 injected inject VBN cord-015306-us58wwmp 1746 17 into into IN cord-015306-us58wwmp 1746 18 the the DT cord-015306-us58wwmp 1746 19 left left JJ cord-015306-us58wwmp 1746 20 kidney kidney NN cord-015306-us58wwmp 1746 21 via via IN cord-015306-us58wwmp 1746 22 retroperitoneal retroperitoneal JJ cord-015306-us58wwmp 1746 23 approach approach NN cord-015306-us58wwmp 1746 24 3 3 CD cord-015306-us58wwmp 1746 25 days day NNS cord-015306-us58wwmp 1746 26 after after IN cord-015306-us58wwmp 1746 27 the the DT cord-015306-us58wwmp 1746 28 initial initial JJ cord-015306-us58wwmp 1746 29 UUO UUO NNP cord-015306-us58wwmp 1746 30 or or CC cord-015306-us58wwmp 1746 31 sham sham JJ cord-015306-us58wwmp 1746 32 operation operation NN cord-015306-us58wwmp 1746 33 . . . cord-015306-us58wwmp 1747 1 Histology histology NN cord-015306-us58wwmp 1747 2 : : : cord-015306-us58wwmp 1748 1 Immunohistochemistry Immunohistochemistry NNP cord-015306-us58wwmp 1748 2 ( ( -LRB- cord-015306-us58wwmp 1748 3 IHC IHC NNP cord-015306-us58wwmp 1748 4 ) ) -RRB- cord-015306-us58wwmp 1748 5 was be VBD cord-015306-us58wwmp 1748 6 performed perform VBN cord-015306-us58wwmp 1748 7 on on IN cord-015306-us58wwmp 1748 8 paraffin paraffin NN cord-015306-us58wwmp 1748 9 sections section NNS cord-015306-us58wwmp 1748 10 to to TO cord-015306-us58wwmp 1748 11 identify identify VB cord-015306-us58wwmp 1748 12 macrophages macrophage NNS cord-015306-us58wwmp 1748 13 and and CC cord-015306-us58wwmp 1748 14 apoptotic apoptotic JJ cord-015306-us58wwmp 1748 15 cells cell NNS cord-015306-us58wwmp 1748 16 , , , cord-015306-us58wwmp 1748 17 and and CC cord-015306-us58wwmp 1748 18 trichrome trichrome JJ cord-015306-us58wwmp 1748 19 stain stain NN cord-015306-us58wwmp 1748 20 was be VBD cord-015306-us58wwmp 1748 21 used use VBN cord-015306-us58wwmp 1748 22 to to TO cord-015306-us58wwmp 1748 23 evaluate evaluate VB cord-015306-us58wwmp 1748 24 fibrosis fibrosis NN cord-015306-us58wwmp 1748 25 . . . cord-015306-us58wwmp 1749 1 Cells cell NNS cord-015306-us58wwmp 1749 2 and and CC cord-015306-us58wwmp 1749 3 total total JJ cord-015306-us58wwmp 1749 4 area area NN cord-015306-us58wwmp 1749 5 were be VBD cord-015306-us58wwmp 1749 6 quantified quantify VBN cord-015306-us58wwmp 1749 7 for for IN cord-015306-us58wwmp 1749 8 IHC IHC NNP cord-015306-us58wwmp 1749 9 and and CC cord-015306-us58wwmp 1749 10 total total JJ cord-015306-us58wwmp 1749 11 fibrotic fibrotic JJ cord-015306-us58wwmp 1749 12 area area NN cord-015306-us58wwmp 1749 13 was be VBD cord-015306-us58wwmp 1749 14 quantified quantify VBN cord-015306-us58wwmp 1749 15 for for IN cord-015306-us58wwmp 1749 16 trichrome trichrome JJ cord-015306-us58wwmp 1749 17 . . . cord-015306-us58wwmp 1750 1 Results result NNS cord-015306-us58wwmp 1750 2 : : : cord-015306-us58wwmp 1751 1 Comparing compare VBG cord-015306-us58wwmp 1751 2 the the DT cord-015306-us58wwmp 1751 3 treatment treatment NN cord-015306-us58wwmp 1751 4 groups group NNS cord-015306-us58wwmp 1751 5 to to IN cord-015306-us58wwmp 1751 6 the the DT cord-015306-us58wwmp 1751 7 untreated untreated JJ cord-015306-us58wwmp 1751 8 UUO UUO NNP cord-015306-us58wwmp 1751 9 , , , cord-015306-us58wwmp 1751 10 macrophage macrophage NN cord-015306-us58wwmp 1751 11 infiltration infiltration NN cord-015306-us58wwmp 1751 12 and and CC cord-015306-us58wwmp 1751 13 apoptosis apoptosis NN cord-015306-us58wwmp 1751 14 were be VBD cord-015306-us58wwmp 1751 15 significantly significantly RB cord-015306-us58wwmp 1751 16 reduced reduce VBN cord-015306-us58wwmp 1751 17 at at IN cord-015306-us58wwmp 1751 18 day day NN cord-015306-us58wwmp 1751 19 21 21 CD cord-015306-us58wwmp 1751 20 and and CC cord-015306-us58wwmp 1751 21 35 35 CD cord-015306-us58wwmp 1751 22 . . . cord-015306-us58wwmp 1752 1 By by IN cord-015306-us58wwmp 1752 2 day day NN cord-015306-us58wwmp 1752 3 35 35 CD cord-015306-us58wwmp 1752 4 , , , cord-015306-us58wwmp 1752 5 adding add VBG cord-015306-us58wwmp 1752 6 the the DT cord-015306-us58wwmp 1752 7 IL-10 IL-10 NNP cord-015306-us58wwmp 1752 8 via via IN cord-015306-us58wwmp 1752 9 gel gel NN cord-015306-us58wwmp 1752 10 injection injection NN cord-015306-us58wwmp 1752 11 reduced reduce VBN cord-015306-us58wwmp 1752 12 macrophage macrophage NN cord-015306-us58wwmp 1752 13 infiltration infiltration NN cord-015306-us58wwmp 1752 14 more more JJR cord-015306-us58wwmp 1752 15 than than IN cord-015306-us58wwmp 1752 16 IL-10 IL-10 NNP cord-015306-us58wwmp 1752 17 alone alone RB cord-015306-us58wwmp 1752 18 and and CC cord-015306-us58wwmp 1752 19 IL-10 IL-10 NNP cord-015306-us58wwmp 1752 20 alone alone RB cord-015306-us58wwmp 1752 21 did do VBD cord-015306-us58wwmp 1752 22 not not RB cord-015306-us58wwmp 1752 23 reduce reduce VB cord-015306-us58wwmp 1752 24 apoptosis apoptosis NN cord-015306-us58wwmp 1752 25 . . . cord-015306-us58wwmp 1753 1 Fibrosis fibrosis NN cord-015306-us58wwmp 1753 2 was be VBD cord-015306-us58wwmp 1753 3 decreased decrease VBN cord-015306-us58wwmp 1753 4 by by IN cord-015306-us58wwmp 1753 5 day day NN cord-015306-us58wwmp 1753 6 35 35 CD cord-015306-us58wwmp 1753 7 in in IN cord-015306-us58wwmp 1753 8 all all DT cord-015306-us58wwmp 1753 9 three three CD cord-015306-us58wwmp 1753 10 treatment treatment NN cord-015306-us58wwmp 1753 11 groups group NNS cord-015306-us58wwmp 1753 12 ( ( -LRB- cord-015306-us58wwmp 1753 13 Fig Fig NNP cord-015306-us58wwmp 1753 14 . . NNP cord-015306-us58wwmp 1753 15 2 2 CD cord-015306-us58wwmp 1753 16 ) ) -RRB- cord-015306-us58wwmp 1753 17 . . . cord-015306-us58wwmp 1754 1 Conclusion conclusion NN cord-015306-us58wwmp 1754 2 : : : cord-015306-us58wwmp 1755 1 Injectable injectable JJ cord-015306-us58wwmp 1755 2 hydrogels hydrogel NNS cord-015306-us58wwmp 1755 3 were be VBD cord-015306-us58wwmp 1755 4 synthesized synthesize VBN cord-015306-us58wwmp 1755 5 that that WDT cord-015306-us58wwmp 1755 6 permit permit VBP cord-015306-us58wwmp 1755 7 facile facile JJ cord-015306-us58wwmp 1755 8 local local JJ cord-015306-us58wwmp 1755 9 delivery delivery NN cord-015306-us58wwmp 1755 10 of of IN cord-015306-us58wwmp 1755 11 immunotherapy immunotherapy NN cord-015306-us58wwmp 1755 12 to to IN cord-015306-us58wwmp 1755 13 both both CC cord-015306-us58wwmp 1755 14 healthy healthy JJ cord-015306-us58wwmp 1755 15 and and CC cord-015306-us58wwmp 1755 16 obstructed obstructed JJ cord-015306-us58wwmp 1755 17 kidneys kidney NNS cord-015306-us58wwmp 1755 18 . . . cord-015306-us58wwmp 1756 1 Renal renal JJ cord-015306-us58wwmp 1756 2 inflammation inflammation NN cord-015306-us58wwmp 1756 3 and and CC cord-015306-us58wwmp 1756 4 scarring scarring NN cord-015306-us58wwmp 1756 5 was be VBD cord-015306-us58wwmp 1756 6 reduced reduce VBN cord-015306-us58wwmp 1756 7 in in IN cord-015306-us58wwmp 1756 8 an an DT cord-015306-us58wwmp 1756 9 animal animal NN cord-015306-us58wwmp 1756 10 model model NN cord-015306-us58wwmp 1756 11 of of IN cord-015306-us58wwmp 1756 12 CKD CKD NNP cord-015306-us58wwmp 1756 13 by by IN cord-015306-us58wwmp 1756 14 using use VBG cord-015306-us58wwmp 1756 15 an an DT cord-015306-us58wwmp 1756 16 injectable injectable JJ cord-015306-us58wwmp 1756 17 hydrogel hydrogel NN cord-015306-us58wwmp 1756 18 for for IN cord-015306-us58wwmp 1756 19 drug drug NN cord-015306-us58wwmp 1756 20 delivery delivery NN cord-015306-us58wwmp 1756 21 . . . cord-015306-us58wwmp 1757 1 Logistic logistic JJ cord-015306-us58wwmp 1757 2 regression regression NN cord-015306-us58wwmp 1757 3 reveled revel VBD cord-015306-us58wwmp 1757 4 that that IN cord-015306-us58wwmp 1757 5 APD APD NNP cord-015306-us58wwmp 1757 6 was be VBD cord-015306-us58wwmp 1757 7 the the DT cord-015306-us58wwmp 1757 8 main main JJ cord-015306-us58wwmp 1757 9 parameter parameter NN cord-015306-us58wwmp 1757 10 significantly significantly RB cord-015306-us58wwmp 1757 11 associated associate VBN cord-015306-us58wwmp 1757 12 with with IN cord-015306-us58wwmp 1757 13 surgery surgery NN cord-015306-us58wwmp 1757 14 treated treat VBN cord-015306-us58wwmp 1757 15 UPJO UPJO NNP cord-015306-us58wwmp 1757 16 cases case NNS cord-015306-us58wwmp 1757 17 ( ( -LRB- cord-015306-us58wwmp 1757 18 ROC ROC NNP cord-015306-us58wwmp 1757 19 plot plot NN cord-015306-us58wwmp 1757 20 was be VBD cord-015306-us58wwmp 1757 21 0.79 0.79 CD cord-015306-us58wwmp 1757 22 ) ) -RRB- cord-015306-us58wwmp 1757 23 . . . cord-015306-us58wwmp 1758 1 A a DT cord-015306-us58wwmp 1758 2 possible possible JJ cord-015306-us58wwmp 1758 3 threshold threshold NN cord-015306-us58wwmp 1758 4 of of IN cord-015306-us58wwmp 1758 5 14 14 CD cord-015306-us58wwmp 1758 6 mm mm NN cord-015306-us58wwmp 1758 7 APD APD NNP cord-015306-us58wwmp 1758 8 may may MD cord-015306-us58wwmp 1758 9 be be VB cord-015306-us58wwmp 1758 10 used use VBN cord-015306-us58wwmp 1758 11 as as IN cord-015306-us58wwmp 1758 12 a a DT cord-015306-us58wwmp 1758 13 cut cut VBN cord-015306-us58wwmp 1758 14 - - HYPH cord-015306-us58wwmp 1758 15 off off RP cord-015306-us58wwmp 1758 16 value value NN cord-015306-us58wwmp 1758 17 of of IN cord-015306-us58wwmp 1758 18 surgery surgery NN cord-015306-us58wwmp 1758 19 treated treat VBN cord-015306-us58wwmp 1758 20 UPJO UPJO NNP cord-015306-us58wwmp 1758 21 group group NN cord-015306-us58wwmp 1758 22 with with IN cord-015306-us58wwmp 1758 23 a a DT cord-015306-us58wwmp 1758 24 sensitivity sensitivity NN cord-015306-us58wwmp 1758 25 of of IN cord-015306-us58wwmp 1758 26 77 77 CD cord-015306-us58wwmp 1758 27 % % NN cord-015306-us58wwmp 1758 28 and and CC cord-015306-us58wwmp 1758 29 a a DT cord-015306-us58wwmp 1758 30 specificity specificity NN cord-015306-us58wwmp 1758 31 of of IN cord-015306-us58wwmp 1758 32 69 69 CD cord-015306-us58wwmp 1758 33 % % NN cord-015306-us58wwmp 1758 34 . . . cord-015306-us58wwmp 1759 1 Conclusion conclusion NN cord-015306-us58wwmp 1759 2 : : : cord-015306-us58wwmp 1759 3 APD APD NNP cord-015306-us58wwmp 1759 4 dilatation dilatation NN cord-015306-us58wwmp 1759 5 was be VBD cord-015306-us58wwmp 1759 6 the the DT cord-015306-us58wwmp 1759 7 strongest strong JJS cord-015306-us58wwmp 1759 8 predictor predictor NN cord-015306-us58wwmp 1759 9 of of IN cord-015306-us58wwmp 1759 10 surgery surgery NN cord-015306-us58wwmp 1759 11 treated treat VBN cord-015306-us58wwmp 1759 12 UPJO UPJO NNP cord-015306-us58wwmp 1759 13 . . . cord-015306-us58wwmp 1760 1 PT pt NN cord-015306-us58wwmp 1760 2 and and CC cord-015306-us58wwmp 1760 3 renal renal JJ cord-015306-us58wwmp 1760 4 length length NN cord-015306-us58wwmp 1760 5 also also RB cord-015306-us58wwmp 1760 6 significantly significantly RB cord-015306-us58wwmp 1760 7 discriminate discriminate VBP cord-015306-us58wwmp 1760 8 the the DT cord-015306-us58wwmp 1760 9 two two CD cord-015306-us58wwmp 1760 10 groups group NNS cord-015306-us58wwmp 1760 11 and and CC cord-015306-us58wwmp 1760 12 correlate correlate VB cord-015306-us58wwmp 1760 13 with with IN cord-015306-us58wwmp 1760 14 APD APD NNP cord-015306-us58wwmp 1760 15 , , , cord-015306-us58wwmp 1760 16 only only RB cord-015306-us58wwmp 1760 17 with with IN cord-015306-us58wwmp 1760 18 lower low JJR cord-015306-us58wwmp 1760 19 predictive predictive JJ cord-015306-us58wwmp 1760 20 power power NN cord-015306-us58wwmp 1760 21 . . . cord-015306-us58wwmp 1761 1 Our -PRON- PRP$ cord-015306-us58wwmp 1761 2 findings finding NNS cord-015306-us58wwmp 1761 3 expand expand VBP cord-015306-us58wwmp 1761 4 the the DT cord-015306-us58wwmp 1761 5 clinical clinical JJ cord-015306-us58wwmp 1761 6 knowledge knowledge NN cord-015306-us58wwmp 1761 7 in in IN cord-015306-us58wwmp 1761 8 the the DT cord-015306-us58wwmp 1761 9 field field NN cord-015306-us58wwmp 1761 10 of of IN cord-015306-us58wwmp 1761 11 prenatal prenatal JJ cord-015306-us58wwmp 1761 12 consult consult NN cord-015306-us58wwmp 1761 13 by by IN cord-015306-us58wwmp 1761 14 highlighting highlight VBG cord-015306-us58wwmp 1761 15 a a DT cord-015306-us58wwmp 1761 16 threshold threshold NN cord-015306-us58wwmp 1761 17 of of IN cord-015306-us58wwmp 1761 18 APD APD NNP cord-015306-us58wwmp 1761 19 , , , cord-015306-us58wwmp 1761 20 which which WDT cord-015306-us58wwmp 1761 21 predicts predict VBZ cord-015306-us58wwmp 1761 22 the the DT cord-015306-us58wwmp 1761 23 need need NN cord-015306-us58wwmp 1761 24 for for IN cord-015306-us58wwmp 1761 25 surgery surgery NN cord-015306-us58wwmp 1761 26 in in IN cord-015306-us58wwmp 1761 27 prenatally prenatally RB cord-015306-us58wwmp 1761 28 detected detect VBN cord-015306-us58wwmp 1761 29 HN HN NNP cord-015306-us58wwmp 1761 30 cases case NNS cord-015306-us58wwmp 1761 31 . . . cord-015306-us58wwmp 1762 1 Abstract abstract JJ cord-015306-us58wwmp 1762 2 # # NN cord-015306-us58wwmp 1762 3 P p NN cord-015306-us58wwmp 1762 4 - - HYPH cord-015306-us58wwmp 1762 5 SAT221 sat221 NN cord-015306-us58wwmp 1762 6 Survival survival NN cord-015306-us58wwmp 1762 7 and and CC cord-015306-us58wwmp 1762 8 renal renal JJ cord-015306-us58wwmp 1762 9 outcome outcome NN cord-015306-us58wwmp 1762 10 in in IN cord-015306-us58wwmp 1762 11 fetuses fetus NNS cord-015306-us58wwmp 1762 12 with with IN cord-015306-us58wwmp 1762 13 Lower low JJR cord-015306-us58wwmp 1762 14 Urinary urinary JJ cord-015306-us58wwmp 1762 15 Obstruction obstruction NN cord-015306-us58wwmp 1762 16 ( ( -LRB- cord-015306-us58wwmp 1762 17 LUTO LUTO NNP cord-015306-us58wwmp 1762 18 ) ) -RRB- cord-015306-us58wwmp 1762 19 with with IN cord-015306-us58wwmp 1762 20 and and CC cord-015306-us58wwmp 1762 21 without without IN cord-015306-us58wwmp 1762 22 intra intra JJ cord-015306-us58wwmp 1762 23 - - JJ cord-015306-us58wwmp 1762 24 uterine uterine JJ cord-015306-us58wwmp 1762 25 vesicoamniotic vesicoamniotic JJ cord-015306-us58wwmp 1762 26 shunting shunting NN cord-015306-us58wwmp 1762 27 . . . cord-015306-us58wwmp 1763 1 A a DT cord-015306-us58wwmp 1763 2 ten ten CD cord-015306-us58wwmp 1763 3 years year NNS cord-015306-us58wwmp 1763 4 experience experience NN cord-015306-us58wwmp 1763 5 of of IN cord-015306-us58wwmp 1763 6 a a DT cord-015306-us58wwmp 1763 7 cohort cohort NN cord-015306-us58wwmp 1763 8 . . . cord-015306-us58wwmp 1764 1 Objective objective NN cord-015306-us58wwmp 1764 2 : : : cord-015306-us58wwmp 1765 1 Ureteropelvic ureteropelvic JJ cord-015306-us58wwmp 1765 2 junction junction NN cord-015306-us58wwmp 1765 3 obstruction obstruction NN cord-015306-us58wwmp 1765 4 ( ( -LRB- cord-015306-us58wwmp 1765 5 UPJO UPJO NNP cord-015306-us58wwmp 1765 6 ) ) -RRB- cord-015306-us58wwmp 1765 7 is be VBZ cord-015306-us58wwmp 1765 8 the the DT cord-015306-us58wwmp 1765 9 most most RBS cord-015306-us58wwmp 1765 10 common common JJ cord-015306-us58wwmp 1765 11 cause cause NN cord-015306-us58wwmp 1765 12 of of IN cord-015306-us58wwmp 1765 13 hydronephrosis hydronephrosis NN cord-015306-us58wwmp 1765 14 in in IN cord-015306-us58wwmp 1765 15 children child NNS cord-015306-us58wwmp 1765 16 . . . cord-015306-us58wwmp 1766 1 The the DT cord-015306-us58wwmp 1766 2 significant significant JJ cord-015306-us58wwmp 1766 3 role role NN cord-015306-us58wwmp 1766 4 of of IN cord-015306-us58wwmp 1766 5 the the DT cord-015306-us58wwmp 1766 6 surgical surgical JJ cord-015306-us58wwmp 1766 7 relieving relieving NN cord-015306-us58wwmp 1766 8 of of IN cord-015306-us58wwmp 1766 9 high high JJ cord-015306-us58wwmp 1766 10 grade grade NN cord-015306-us58wwmp 1766 11 obstruction obstruction NN cord-015306-us58wwmp 1766 12 is be VBZ cord-015306-us58wwmp 1766 13 indisputable indisputable JJ cord-015306-us58wwmp 1766 14 . . . cord-015306-us58wwmp 1767 1 Nevertheless nevertheless RB cord-015306-us58wwmp 1767 2 , , , cord-015306-us58wwmp 1767 3 the the DT cord-015306-us58wwmp 1767 4 effect effect NN cord-015306-us58wwmp 1767 5 of of IN cord-015306-us58wwmp 1767 6 pyeloplasty pyeloplasty NN cord-015306-us58wwmp 1767 7 on on IN cord-015306-us58wwmp 1767 8 the the DT cord-015306-us58wwmp 1767 9 function function NN cord-015306-us58wwmp 1767 10 of of IN cord-015306-us58wwmp 1767 11 the the DT cord-015306-us58wwmp 1767 12 involved involved JJ cord-015306-us58wwmp 1767 13 kidney kidney NN cord-015306-us58wwmp 1767 14 remains remain VBZ cord-015306-us58wwmp 1767 15 controversial controversial JJ cord-015306-us58wwmp 1767 16 , , , cord-015306-us58wwmp 1767 17 especially especially RB cord-015306-us58wwmp 1767 18 in in IN cord-015306-us58wwmp 1767 19 UPJO UPJO NNP cord-015306-us58wwmp 1767 20 with with IN cord-015306-us58wwmp 1767 21 significantly significantly RB cord-015306-us58wwmp 1767 22 reduced reduce VBN cord-015306-us58wwmp 1767 23 relative relative JJ cord-015306-us58wwmp 1767 24 renal renal JJ cord-015306-us58wwmp 1767 25 function function NN cord-015306-us58wwmp 1767 26 ( ( -LRB- cord-015306-us58wwmp 1767 27 RRF RRF NNP cord-015306-us58wwmp 1767 28 ) ) -RRB- cord-015306-us58wwmp 1767 29 before before IN cord-015306-us58wwmp 1767 30 surgery surgery NN cord-015306-us58wwmp 1767 31 . . . cord-015306-us58wwmp 1768 1 To to TO cord-015306-us58wwmp 1768 2 evaluate evaluate VB cord-015306-us58wwmp 1768 3 the the DT cord-015306-us58wwmp 1768 4 effect effect NN cord-015306-us58wwmp 1768 5 of of IN cord-015306-us58wwmp 1768 6 pyeloplasty pyeloplasty NN cord-015306-us58wwmp 1768 7 on on IN cord-015306-us58wwmp 1768 8 the the DT cord-015306-us58wwmp 1768 9 relative relative JJ cord-015306-us58wwmp 1768 10 function function NN cord-015306-us58wwmp 1768 11 of of IN cord-015306-us58wwmp 1768 12 kidneys kidney NNS cord-015306-us58wwmp 1768 13 in in IN cord-015306-us58wwmp 1768 14 children child NNS cord-015306-us58wwmp 1768 15 with with IN cord-015306-us58wwmp 1768 16 UPJO UPJO NNP cord-015306-us58wwmp 1768 17 and and CC cord-015306-us58wwmp 1768 18 decreased decrease VBD cord-015306-us58wwmp 1768 19 RRF RRF NNP cord-015306-us58wwmp 1768 20 . . . cord-015306-us58wwmp 1769 1 Methods method NNS cord-015306-us58wwmp 1769 2 : : : cord-015306-us58wwmp 1770 1 The the DT cord-015306-us58wwmp 1770 2 records record NNS cord-015306-us58wwmp 1770 3 of of IN cord-015306-us58wwmp 1770 4 children child NNS cord-015306-us58wwmp 1770 5 who who WP cord-015306-us58wwmp 1770 6 underwent undergo VBD cord-015306-us58wwmp 1770 7 pyeloplasty pyeloplasty NN cord-015306-us58wwmp 1770 8 for for IN cord-015306-us58wwmp 1770 9 UPJO UPJO NNP cord-015306-us58wwmp 1770 10 during during IN cord-015306-us58wwmp 1770 11 a a DT cord-015306-us58wwmp 1770 12 10 10 CD cord-015306-us58wwmp 1770 13 year year NN cord-015306-us58wwmp 1770 14 period period NN cord-015306-us58wwmp 1770 15 in in IN cord-015306-us58wwmp 1770 16 Schneider Schneider NNP cord-015306-us58wwmp 1770 17 Children Children NNP cord-015306-us58wwmp 1770 18 's 's POS cord-015306-us58wwmp 1770 19 Medical Medical NNP cord-015306-us58wwmp 1770 20 Center Center NNP cord-015306-us58wwmp 1770 21 of of IN cord-015306-us58wwmp 1770 22 Israel Israel NNP cord-015306-us58wwmp 1770 23 were be VBD cord-015306-us58wwmp 1770 24 reviewed review VBN cord-015306-us58wwmp 1770 25 . . . cord-015306-us58wwmp 1771 1 The the DT cord-015306-us58wwmp 1771 2 study study NN cord-015306-us58wwmp 1771 3 group group NN cord-015306-us58wwmp 1771 4 included include VBD cord-015306-us58wwmp 1771 5 40 40 CD cord-015306-us58wwmp 1771 6 children child NNS cord-015306-us58wwmp 1771 7 who who WP cord-015306-us58wwmp 1771 8 underwent undergo VBD cord-015306-us58wwmp 1771 9 pyeloplasty pyeloplasty NN cord-015306-us58wwmp 1771 10 for for IN cord-015306-us58wwmp 1771 11 UPJO UPJO NNP cord-015306-us58wwmp 1771 12 and and CC cord-015306-us58wwmp 1771 13 had have VBD cord-015306-us58wwmp 1771 14 an an DT cord-015306-us58wwmp 1771 15 initial initial JJ cord-015306-us58wwmp 1771 16 RRF RRF NNP cord-015306-us58wwmp 1771 17 < < XX cord-015306-us58wwmp 1771 18 40 40 CD cord-015306-us58wwmp 1771 19 % % NN cord-015306-us58wwmp 1771 20 . . . cord-015306-us58wwmp 1772 1 Children child NNS cord-015306-us58wwmp 1772 2 with with IN cord-015306-us58wwmp 1772 3 bilateral bilateral JJ cord-015306-us58wwmp 1772 4 UPJO UPJO NNP cord-015306-us58wwmp 1772 5 , , , cord-015306-us58wwmp 1772 6 solitary solitary JJ cord-015306-us58wwmp 1772 7 kidney kidney NN cord-015306-us58wwmp 1772 8 or or CC cord-015306-us58wwmp 1772 9 other other JJ cord-015306-us58wwmp 1772 10 genito genito JJ cord-015306-us58wwmp 1772 11 urinary urinary JJ cord-015306-us58wwmp 1772 12 abnormalities abnormality NNS cord-015306-us58wwmp 1772 13 were be VBD cord-015306-us58wwmp 1772 14 excluded exclude VBN cord-015306-us58wwmp 1772 15 . . . cord-015306-us58wwmp 1773 1 The the DT cord-015306-us58wwmp 1773 2 control control NN cord-015306-us58wwmp 1773 3 group group NN cord-015306-us58wwmp 1773 4 included include VBD cord-015306-us58wwmp 1773 5 38 38 CD cord-015306-us58wwmp 1773 6 children child NNS cord-015306-us58wwmp 1773 7 with with IN cord-015306-us58wwmp 1773 8 non non JJ cord-015306-us58wwmp 1773 9 obstructive obstructive JJ cord-015306-us58wwmp 1773 10 hydronephrosis hydronephrosis NN cord-015306-us58wwmp 1773 11 and and CC cord-015306-us58wwmp 1773 12 an an DT cord-015306-us58wwmp 1773 13 initial initial JJ cord-015306-us58wwmp 1773 14 RRF<40 rrf<40 NN cord-015306-us58wwmp 1773 15 % % NN cord-015306-us58wwmp 1773 16 . . . cord-015306-us58wwmp 1774 1 Results result NNS cord-015306-us58wwmp 1774 2 : : : cord-015306-us58wwmp 1775 1 The the DT cord-015306-us58wwmp 1775 2 average average JJ cord-015306-us58wwmp 1775 3 initial initial JJ cord-015306-us58wwmp 1775 4 RRF rrf NN cord-015306-us58wwmp 1775 5 in in IN cord-015306-us58wwmp 1775 6 the the DT cord-015306-us58wwmp 1775 7 study study NN cord-015306-us58wwmp 1775 8 group group NN cord-015306-us58wwmp 1775 9 was be VBD cord-015306-us58wwmp 1775 10 26 26 CD cord-015306-us58wwmp 1775 11 % % NN cord-015306-us58wwmp 1775 12 ( ( -LRB- cord-015306-us58wwmp 1775 13 range range NNP cord-015306-us58wwmp 1775 14 8 8 CD cord-015306-us58wwmp 1775 15 - - SYM cord-015306-us58wwmp 1775 16 39 39 CD cord-015306-us58wwmp 1775 17 % % NN cord-015306-us58wwmp 1775 18 ) ) -RRB- cord-015306-us58wwmp 1775 19 , , , cord-015306-us58wwmp 1775 20 and and CC cord-015306-us58wwmp 1775 21 the the DT cord-015306-us58wwmp 1775 22 final final JJ cord-015306-us58wwmp 1775 23 renal renal JJ cord-015306-us58wwmp 1775 24 function function NN cord-015306-us58wwmp 1775 25 was be VBD cord-015306-us58wwmp 1775 26 32 32 CD cord-015306-us58wwmp 1775 27 % % NN cord-015306-us58wwmp 1775 28 ( ( -LRB- cord-015306-us58wwmp 1775 29 1 1 CD cord-015306-us58wwmp 1775 30 - - SYM cord-015306-us58wwmp 1775 31 55 55 CD cord-015306-us58wwmp 1775 32 % % NN cord-015306-us58wwmp 1775 33 ) ) -RRB- cord-015306-us58wwmp 1775 34 . . . cord-015306-us58wwmp 1776 1 In in IN cord-015306-us58wwmp 1776 2 the the DT cord-015306-us58wwmp 1776 3 control control NN cord-015306-us58wwmp 1776 4 group group NN cord-015306-us58wwmp 1776 5 , , , cord-015306-us58wwmp 1776 6 the the DT cord-015306-us58wwmp 1776 7 initial initial JJ cord-015306-us58wwmp 1776 8 RRF RRF NNP cord-015306-us58wwmp 1776 9 was be VBD cord-015306-us58wwmp 1776 10 23 23 CD cord-015306-us58wwmp 1776 11 % % NN cord-015306-us58wwmp 1776 12 ( ( -LRB- cord-015306-us58wwmp 1776 13 2 2 CD cord-015306-us58wwmp 1776 14 - - SYM cord-015306-us58wwmp 1776 15 40 40 CD cord-015306-us58wwmp 1776 16 % % NN cord-015306-us58wwmp 1776 17 ) ) -RRB- cord-015306-us58wwmp 1776 18 , , , cord-015306-us58wwmp 1776 19 and and CC cord-015306-us58wwmp 1776 20 the the DT cord-015306-us58wwmp 1776 21 final final JJ cord-015306-us58wwmp 1776 22 function function NN cord-015306-us58wwmp 1776 23 was be VBD cord-015306-us58wwmp 1776 24 22 22 CD cord-015306-us58wwmp 1776 25 % % NN cord-015306-us58wwmp 1776 26 ( ( -LRB- cord-015306-us58wwmp 1776 27 0 0 CD cord-015306-us58wwmp 1776 28 - - SYM cord-015306-us58wwmp 1776 29 44 44 CD cord-015306-us58wwmp 1776 30 % % NN cord-015306-us58wwmp 1776 31 ) ) -RRB- cord-015306-us58wwmp 1776 32 . . . cord-015306-us58wwmp 1777 1 The the DT cord-015306-us58wwmp 1777 2 final final JJ cord-015306-us58wwmp 1777 3 RRF rrf NN cord-015306-us58wwmp 1777 4 of of IN cord-015306-us58wwmp 1777 5 the the DT cord-015306-us58wwmp 1777 6 study study NN cord-015306-us58wwmp 1777 7 group group NN cord-015306-us58wwmp 1777 8 was be VBD cord-015306-us58wwmp 1777 9 significantly significantly RB cord-015306-us58wwmp 1777 10 higher high JJR cord-015306-us58wwmp 1777 11 comparing compare VBG cord-015306-us58wwmp 1777 12 to to IN cord-015306-us58wwmp 1777 13 the the DT cord-015306-us58wwmp 1777 14 control control NN cord-015306-us58wwmp 1777 15 group group NN cord-015306-us58wwmp 1777 16 ( ( -LRB- cord-015306-us58wwmp 1777 17 P p NN cord-015306-us58wwmp 1777 18 value<0.05 value<0.05 NNP cord-015306-us58wwmp 1777 19 ) ) -RRB- cord-015306-us58wwmp 1777 20 . . . cord-015306-us58wwmp 1778 1 In in IN cord-015306-us58wwmp 1778 2 the the DT cord-015306-us58wwmp 1778 3 subgroup subgroup NN cord-015306-us58wwmp 1778 4 of of IN cord-015306-us58wwmp 1778 5 patients patient NNS cord-015306-us58wwmp 1778 6 with with IN cord-015306-us58wwmp 1778 7 UPJO UPJO NNP cord-015306-us58wwmp 1778 8 and and CC cord-015306-us58wwmp 1778 9 initial initial JJ cord-015306-us58wwmp 1778 10 RRF<30 RRF<30 '' cord-015306-us58wwmp 1778 11 % % NN cord-015306-us58wwmp 1778 12 ( ( -LRB- cord-015306-us58wwmp 1778 13 24 24 CD cord-015306-us58wwmp 1778 14 patients patient NNS cord-015306-us58wwmp 1778 15 ) ) -RRB- cord-015306-us58wwmp 1778 16 the the DT cord-015306-us58wwmp 1778 17 average average JJ cord-015306-us58wwmp 1778 18 initial initial JJ cord-015306-us58wwmp 1778 19 function function NN cord-015306-us58wwmp 1778 20 was be VBD cord-015306-us58wwmp 1778 21 20 20 CD cord-015306-us58wwmp 1778 22 % % NN cord-015306-us58wwmp 1778 23 ( ( -LRB- cord-015306-us58wwmp 1778 24 8 8 CD cord-015306-us58wwmp 1778 25 - - SYM cord-015306-us58wwmp 1778 26 30 30 CD cord-015306-us58wwmp 1778 27 % % NN cord-015306-us58wwmp 1778 28 ) ) -RRB- cord-015306-us58wwmp 1778 29 and and CC cord-015306-us58wwmp 1778 30 the the DT cord-015306-us58wwmp 1778 31 final final JJ cord-015306-us58wwmp 1778 32 function function NN cord-015306-us58wwmp 1778 33 was be VBD cord-015306-us58wwmp 1778 34 27 27 CD cord-015306-us58wwmp 1778 35 % % NN cord-015306-us58wwmp 1778 36 ( ( -LRB- cord-015306-us58wwmp 1778 37 3 3 CD cord-015306-us58wwmp 1778 38 - - SYM cord-015306-us58wwmp 1778 39 55 55 CD cord-015306-us58wwmp 1778 40 % % NN cord-015306-us58wwmp 1778 41 ) ) -RRB- cord-015306-us58wwmp 1778 42 . . . cord-015306-us58wwmp 1779 1 In in IN cord-015306-us58wwmp 1779 2 the the DT cord-015306-us58wwmp 1779 3 control control NN cord-015306-us58wwmp 1779 4 subgroup subgroup NN cord-015306-us58wwmp 1779 5 with with IN cord-015306-us58wwmp 1779 6 initial initial JJ cord-015306-us58wwmp 1779 7 RRF<30 RRF<30 `` cord-015306-us58wwmp 1779 8 % % NN cord-015306-us58wwmp 1779 9 ( ( -LRB- cord-015306-us58wwmp 1779 10 26 26 CD cord-015306-us58wwmp 1779 11 patients patient NNS cord-015306-us58wwmp 1779 12 ) ) -RRB- cord-015306-us58wwmp 1780 1 the the DT cord-015306-us58wwmp 1780 2 initial initial JJ cord-015306-us58wwmp 1780 3 average average JJ cord-015306-us58wwmp 1780 4 function function NN cord-015306-us58wwmp 1780 5 was be VBD cord-015306-us58wwmp 1780 6 17 17 CD cord-015306-us58wwmp 1780 7 % % NN cord-015306-us58wwmp 1780 8 ( ( -LRB- cord-015306-us58wwmp 1780 9 2 2 CD cord-015306-us58wwmp 1780 10 - - SYM cord-015306-us58wwmp 1780 11 30 30 CD cord-015306-us58wwmp 1780 12 % % NN cord-015306-us58wwmp 1780 13 ) ) -RRB- cord-015306-us58wwmp 1780 14 and and CC cord-015306-us58wwmp 1780 15 the the DT cord-015306-us58wwmp 1780 16 final final JJ cord-015306-us58wwmp 1780 17 function function NN cord-015306-us58wwmp 1780 18 was be VBD cord-015306-us58wwmp 1780 19 17 17 CD cord-015306-us58wwmp 1780 20 % % NN cord-015306-us58wwmp 1780 21 ( ( -LRB- cord-015306-us58wwmp 1780 22 0 0 CD cord-015306-us58wwmp 1780 23 - - SYM cord-015306-us58wwmp 1780 24 44 44 CD cord-015306-us58wwmp 1780 25 % % NN cord-015306-us58wwmp 1780 26 ) ) -RRB- cord-015306-us58wwmp 1780 27 . . . cord-015306-us58wwmp 1781 1 Conclusion conclusion NN cord-015306-us58wwmp 1781 2 : : : cord-015306-us58wwmp 1782 1 Pyeloplasty Pyeloplasty NNP cord-015306-us58wwmp 1782 2 is be VBZ cord-015306-us58wwmp 1782 3 associated associate VBN cord-015306-us58wwmp 1782 4 with with IN cord-015306-us58wwmp 1782 5 an an DT cord-015306-us58wwmp 1782 6 improvement improvement NN cord-015306-us58wwmp 1782 7 of of IN cord-015306-us58wwmp 1782 8 renal renal JJ cord-015306-us58wwmp 1782 9 function function NN cord-015306-us58wwmp 1782 10 in in IN cord-015306-us58wwmp 1782 11 children child NNS cord-015306-us58wwmp 1782 12 with with IN cord-015306-us58wwmp 1782 13 UPJO UPJO NNP cord-015306-us58wwmp 1782 14 and and CC cord-015306-us58wwmp 1782 15 an an DT cord-015306-us58wwmp 1782 16 initial initial JJ cord-015306-us58wwmp 1782 17 RRF RRF NNP cord-015306-us58wwmp 1782 18 < < XX cord-015306-us58wwmp 1782 19 40 40 CD cord-015306-us58wwmp 1782 20 % % NN cord-015306-us58wwmp 1782 21 . . . cord-015306-us58wwmp 1783 1 This this DT cord-015306-us58wwmp 1783 2 is be VBZ cord-015306-us58wwmp 1783 3 also also RB cord-015306-us58wwmp 1783 4 true true JJ cord-015306-us58wwmp 1783 5 for for IN cord-015306-us58wwmp 1783 6 patients patient NNS cord-015306-us58wwmp 1783 7 with with IN cord-015306-us58wwmp 1783 8 RRF<30 rrf<30 ADD cord-015306-us58wwmp 1783 9 % % NN cord-015306-us58wwmp 1783 10 before before IN cord-015306-us58wwmp 1783 11 surgery surgery NN cord-015306-us58wwmp 1783 12 . . . cord-015306-us58wwmp 1784 1 Our -PRON- PRP$ cord-015306-us58wwmp 1784 2 results result NNS cord-015306-us58wwmp 1784 3 support support VBP cord-015306-us58wwmp 1784 4 the the DT cord-015306-us58wwmp 1784 5 need need NN cord-015306-us58wwmp 1784 6 for for IN cord-015306-us58wwmp 1784 7 pyeloplasty pyeloplasty NN cord-015306-us58wwmp 1784 8 in in IN cord-015306-us58wwmp 1784 9 children child NNS cord-015306-us58wwmp 1784 10 with with IN cord-015306-us58wwmp 1784 11 UPJO UPJO NNP cord-015306-us58wwmp 1784 12 and and CC cord-015306-us58wwmp 1784 13 reduced reduce VBN cord-015306-us58wwmp 1784 14 RRF RRF NNP cord-015306-us58wwmp 1784 15 . . . cord-015306-us58wwmp 1785 1 Objective objective JJ cord-015306-us58wwmp 1785 2 : : : cord-015306-us58wwmp 1785 3 common common JJ cord-015306-us58wwmp 1785 4 cause cause NN cord-015306-us58wwmp 1785 5 of of IN cord-015306-us58wwmp 1785 6 chronic chronic JJ cord-015306-us58wwmp 1785 7 kidney kidney NN cord-015306-us58wwmp 1785 8 disease disease NN cord-015306-us58wwmp 1785 9 ( ( -LRB- cord-015306-us58wwmp 1785 10 CKD CKD NNP cord-015306-us58wwmp 1785 11 ) ) -RRB- cord-015306-us58wwmp 1785 12 in in IN cord-015306-us58wwmp 1785 13 children child NNS cord-015306-us58wwmp 1785 14 . . . cord-015306-us58wwmp 1786 1 Kidney kidney NN cord-015306-us58wwmp 1786 2 damage damage NN cord-015306-us58wwmp 1786 3 occurs occur VBZ cord-015306-us58wwmp 1786 4 in in IN cord-015306-us58wwmp 1786 5 utero utero NN cord-015306-us58wwmp 1786 6 , , , cord-015306-us58wwmp 1786 7 and and CC cord-015306-us58wwmp 1786 8 kidney kidney NN cord-015306-us58wwmp 1786 9 disease disease NN cord-015306-us58wwmp 1786 10 progresses progress VBZ cord-015306-us58wwmp 1786 11 postnatally postnatally RB cord-015306-us58wwmp 1786 12 . . . cord-015306-us58wwmp 1787 1 The the DT cord-015306-us58wwmp 1787 2 objective objective NN cord-015306-us58wwmp 1787 3 of of IN cord-015306-us58wwmp 1787 4 this this DT cord-015306-us58wwmp 1787 5 project project NN cord-015306-us58wwmp 1787 6 was be VBD cord-015306-us58wwmp 1787 7 to to TO cord-015306-us58wwmp 1787 8 identify identify VB cord-015306-us58wwmp 1787 9 clinical clinical JJ cord-015306-us58wwmp 1787 10 biomarkers biomarker NNS cord-015306-us58wwmp 1787 11 , , , cord-015306-us58wwmp 1787 12 in in IN cord-015306-us58wwmp 1787 13 particular particular JJ cord-015306-us58wwmp 1787 14 antenatal antenatal JJ cord-015306-us58wwmp 1787 15 variables variable NNS cord-015306-us58wwmp 1787 16 , , , cord-015306-us58wwmp 1787 17 which which WDT cord-015306-us58wwmp 1787 18 predicted predict VBD cord-015306-us58wwmp 1787 19 long long JJ cord-015306-us58wwmp 1787 20 - - HYPH cord-015306-us58wwmp 1787 21 term term NN cord-015306-us58wwmp 1787 22 renal renal JJ cord-015306-us58wwmp 1787 23 outcome outcome NN cord-015306-us58wwmp 1787 24 in in IN cord-015306-us58wwmp 1787 25 boys boy NNS cord-015306-us58wwmp 1787 26 with with IN cord-015306-us58wwmp 1787 27 PUV PUV NNP cord-015306-us58wwmp 1787 28 . . . cord-015306-us58wwmp 1788 1 Methods method NNS cord-015306-us58wwmp 1788 2 : : : cord-015306-us58wwmp 1788 3 This this DT cord-015306-us58wwmp 1788 4 was be VBD cord-015306-us58wwmp 1788 5 a a DT cord-015306-us58wwmp 1788 6 retrospective retrospective JJ cord-015306-us58wwmp 1788 7 cohort cohort NN cord-015306-us58wwmp 1788 8 analysis analysis NN cord-015306-us58wwmp 1788 9 . . . cord-015306-us58wwmp 1789 1 Primary primary JJ cord-015306-us58wwmp 1789 2 outcome outcome NN cord-015306-us58wwmp 1789 3 was be VBD cord-015306-us58wwmp 1789 4 the the DT cord-015306-us58wwmp 1789 5 development development NN cord-015306-us58wwmp 1789 6 of of IN cord-015306-us58wwmp 1789 7 end end NN cord-015306-us58wwmp 1789 8 stage stage NN cord-015306-us58wwmp 1789 9 renal renal JJ cord-015306-us58wwmp 1789 10 disease disease NN cord-015306-us58wwmp 1789 11 ( ( -LRB- cord-015306-us58wwmp 1789 12 ESRD ESRD NNP cord-015306-us58wwmp 1789 13 ) ) -RRB- cord-015306-us58wwmp 1789 14 as as IN cord-015306-us58wwmp 1789 15 defined define VBN cord-015306-us58wwmp 1789 16 as as IN cord-015306-us58wwmp 1789 17 starting start VBG cord-015306-us58wwmp 1789 18 dialysis dialysis NN cord-015306-us58wwmp 1789 19 or or CC cord-015306-us58wwmp 1789 20 preemptive preemptive JJ cord-015306-us58wwmp 1789 21 transplantation transplantation NN cord-015306-us58wwmp 1789 22 . . . cord-015306-us58wwmp 1790 1 Clinical clinical JJ cord-015306-us58wwmp 1790 2 variables variable NNS cord-015306-us58wwmp 1790 3 studied study VBD cord-015306-us58wwmp 1790 4 included include VBD cord-015306-us58wwmp 1790 5 antenatal antenatal JJ cord-015306-us58wwmp 1790 6 factors factor NNS cord-015306-us58wwmp 1790 7 , , , cord-015306-us58wwmp 1790 8 postnatal postnatal JJ cord-015306-us58wwmp 1790 9 renal renal JJ cord-015306-us58wwmp 1790 10 function function NN cord-015306-us58wwmp 1790 11 , , , cord-015306-us58wwmp 1790 12 and and CC cord-015306-us58wwmp 1790 13 modifiable modifiable JJ cord-015306-us58wwmp 1790 14 variables variable NNS cord-015306-us58wwmp 1790 15 . . . cord-015306-us58wwmp 1791 1 Continuous continuous JJ cord-015306-us58wwmp 1791 2 data datum NNS cord-015306-us58wwmp 1791 3 for for IN cord-015306-us58wwmp 1791 4 the the DT cord-015306-us58wwmp 1791 5 two two CD cord-015306-us58wwmp 1791 6 outcome outcome NN cord-015306-us58wwmp 1791 7 groups group NNS cord-015306-us58wwmp 1791 8 were be VBD cord-015306-us58wwmp 1791 9 compared compare VBN cord-015306-us58wwmp 1791 10 , , , cord-015306-us58wwmp 1791 11 receiver receiver NN cord-015306-us58wwmp 1791 12 - - HYPH cord-015306-us58wwmp 1791 13 operating operating NN cord-015306-us58wwmp 1791 14 characteristic characteristic NN cord-015306-us58wwmp 1791 15 ( ( -LRB- cord-015306-us58wwmp 1791 16 ROC ROC NNP cord-015306-us58wwmp 1791 17 ) ) -RRB- cord-015306-us58wwmp 1791 18 , , , cord-015306-us58wwmp 1791 19 Kaplan Kaplan NNP cord-015306-us58wwmp 1791 20 - - HYPH cord-015306-us58wwmp 1791 21 Meier Meier NNP cord-015306-us58wwmp 1791 22 , , , cord-015306-us58wwmp 1791 23 and and CC cord-015306-us58wwmp 1791 24 logistic logistic JJ cord-015306-us58wwmp 1791 25 regression regression NN cord-015306-us58wwmp 1791 26 analyses analysis NNS cord-015306-us58wwmp 1791 27 were be VBD cord-015306-us58wwmp 1791 28 conducted conduct VBN cord-015306-us58wwmp 1791 29 to to TO cord-015306-us58wwmp 1791 30 assess assess VB cord-015306-us58wwmp 1791 31 the the DT cord-015306-us58wwmp 1791 32 robustness robustness NN cord-015306-us58wwmp 1791 33 of of IN cord-015306-us58wwmp 1791 34 each each DT cord-015306-us58wwmp 1791 35 candidate candidate NN cord-015306-us58wwmp 1791 36 biomarker biomarker NN cord-015306-us58wwmp 1791 37 as as IN cord-015306-us58wwmp 1791 38 a a DT cord-015306-us58wwmp 1791 39 predictor predictor NN cord-015306-us58wwmp 1791 40 of of IN cord-015306-us58wwmp 1791 41 outcome outcome NN cord-015306-us58wwmp 1791 42 . . . cord-015306-us58wwmp 1792 1 Results result NNS cord-015306-us58wwmp 1792 2 : : : cord-015306-us58wwmp 1793 1 In in IN cord-015306-us58wwmp 1793 2 this this DT cord-015306-us58wwmp 1793 3 cohort cohort NN cord-015306-us58wwmp 1793 4 15 15 CD cord-015306-us58wwmp 1793 5 cases case NNS cord-015306-us58wwmp 1793 6 reached reach VBD cord-015306-us58wwmp 1793 7 the the DT cord-015306-us58wwmp 1793 8 primary primary JJ cord-015306-us58wwmp 1793 9 outcome outcome NN cord-015306-us58wwmp 1793 10 of of IN cord-015306-us58wwmp 1793 11 end end JJ cord-015306-us58wwmp 1793 12 stage stage NN cord-015306-us58wwmp 1793 13 renal renal JJ cord-015306-us58wwmp 1793 14 disease disease NN cord-015306-us58wwmp 1793 15 at at IN cord-015306-us58wwmp 1793 16 a a DT cord-015306-us58wwmp 1793 17 mean mean JJ cord-015306-us58wwmp 1793 18 age age NN cord-015306-us58wwmp 1793 19 of of IN cord-015306-us58wwmp 1793 20 7.0 7.0 CD cord-015306-us58wwmp 1793 21 ± ± NNP cord-015306-us58wwmp 1793 22 6.7 6.7 CD cord-015306-us58wwmp 1793 23 yrs yr NNS cord-015306-us58wwmp 1793 24 . . . cord-015306-us58wwmp 1794 1 Compared compare VBN cord-015306-us58wwmp 1794 2 to to IN cord-015306-us58wwmp 1794 3 those those DT cord-015306-us58wwmp 1794 4 who who WP cord-015306-us58wwmp 1794 5 did do VBD cord-015306-us58wwmp 1794 6 n't not RB cord-015306-us58wwmp 1794 7 , , , cord-015306-us58wwmp 1794 8 those those DT cord-015306-us58wwmp 1794 9 who who WP cord-015306-us58wwmp 1794 10 progressed progress VBD cord-015306-us58wwmp 1794 11 to to IN cord-015306-us58wwmp 1794 12 ESRD ESRD NNP cord-015306-us58wwmp 1794 13 had have VBD cord-015306-us58wwmp 1794 14 younger young JJR cord-015306-us58wwmp 1794 15 age age NN cord-015306-us58wwmp 1794 16 at at IN cord-015306-us58wwmp 1794 17 diagnosis diagnosis NN cord-015306-us58wwmp 1794 18 ( ( -LRB- cord-015306-us58wwmp 1794 19 0.6 0.6 CD cord-015306-us58wwmp 1794 20 ± ± CD cord-015306-us58wwmp 1794 21 1.5 1.5 CD cord-015306-us58wwmp 1794 22 vs vs IN cord-015306-us58wwmp 1794 23 3.3 3.3 CD cord-015306-us58wwmp 1794 24 ± ± NNP cord-015306-us58wwmp 1794 25 7.3 7.3 CD cord-015306-us58wwmp 1794 26 yrs yr NNS cord-015306-us58wwmp 1794 27 , , , cord-015306-us58wwmp 1794 28 p<0.05 p<0.05 CD cord-015306-us58wwmp 1794 29 ) ) -RRB- cord-015306-us58wwmp 1794 30 , , , cord-015306-us58wwmp 1794 31 valve valve NN cord-015306-us58wwmp 1794 32 ablation ablation NN cord-015306-us58wwmp 1795 1 ( ( -LRB- cord-015306-us58wwmp 1795 2 . . . cord-015306-us58wwmp 1796 1 FSGS fsgs NN cord-015306-us58wwmp 1796 2 rate rate NN cord-015306-us58wwmp 1796 3 was be VBD cord-015306-us58wwmp 1796 4 found find VBN cord-015306-us58wwmp 1796 5 as as IN cord-015306-us58wwmp 1796 6 60 60 CD cord-015306-us58wwmp 1796 7 % % NN cord-015306-us58wwmp 1796 8 in in IN cord-015306-us58wwmp 1796 9 biopsied biopsied JJ cord-015306-us58wwmp 1796 10 subjects subject NNS cord-015306-us58wwmp 1796 11 . . . cord-015306-us58wwmp 1797 1 Nephrotic nephrotic JJ cord-015306-us58wwmp 1797 2 syndrome syndrome NN cord-015306-us58wwmp 1797 3 was be VBD cord-015306-us58wwmp 1797 4 defined define VBN cord-015306-us58wwmp 1797 5 by by IN cord-015306-us58wwmp 1797 6 edema edema NN cord-015306-us58wwmp 1797 7 , , , cord-015306-us58wwmp 1797 8 massive massive JJ cord-015306-us58wwmp 1797 9 proteinuria proteinuria NN cord-015306-us58wwmp 1797 10 ( ( -LRB- cord-015306-us58wwmp 1797 11 > > XX cord-015306-us58wwmp 1798 1 40 40 CD cord-015306-us58wwmp 1798 2 mg mg NNP cord-015306-us58wwmp 1798 3 / / SYM cord-015306-us58wwmp 1798 4 m m NN cord-015306-us58wwmp 1798 5 2 2 CD cord-015306-us58wwmp 1798 6 per per IN cord-015306-us58wwmp 1798 7 hour hour NN cord-015306-us58wwmp 1798 8 or or CC cord-015306-us58wwmp 1798 9 a a DT cord-015306-us58wwmp 1798 10 protein protein NN cord-015306-us58wwmp 1798 11 / / SYM cord-015306-us58wwmp 1798 12 creatinine creatinine NN cord-015306-us58wwmp 1798 13 ratio ratio NN cord-015306-us58wwmp 1798 14 > > XX cord-015306-us58wwmp 1799 1 2.0 2.0 CD cord-015306-us58wwmp 1799 2 mg mg NNP cord-015306-us58wwmp 1799 3 / / SYM cord-015306-us58wwmp 1799 4 mg mg NNP cord-015306-us58wwmp 1799 5 ) ) -RRB- cord-015306-us58wwmp 1799 6 , , , cord-015306-us58wwmp 1799 7 hypoalbuminemia hypoalbuminemia NNP cord-015306-us58wwmp 1799 8 ( ( -LRB- cord-015306-us58wwmp 1799 9 < < NNP cord-015306-us58wwmp 1799 10 2.5 2.5 CD cord-015306-us58wwmp 1799 11 g g NN cord-015306-us58wwmp 1799 12 / / SYM cord-015306-us58wwmp 1799 13 dl dl NNP cord-015306-us58wwmp 1799 14 ) ) -RRB- cord-015306-us58wwmp 1799 15 , , , cord-015306-us58wwmp 1799 16 and and CC cord-015306-us58wwmp 1799 17 hyperlipidemia hyperlipidemia NN cord-015306-us58wwmp 1799 18 . . . cord-015306-us58wwmp 1800 1 Remission remission NN cord-015306-us58wwmp 1800 2 was be VBD cord-015306-us58wwmp 1800 3 defined define VBN cord-015306-us58wwmp 1800 4 as as IN cord-015306-us58wwmp 1800 5 a a DT cord-015306-us58wwmp 1800 6 urinary urinary JJ cord-015306-us58wwmp 1800 7 protein protein NN cord-015306-us58wwmp 1800 8 excretion excretion NN cord-015306-us58wwmp 1800 9 below below IN cord-015306-us58wwmp 1800 10 4 4 CD cord-015306-us58wwmp 1800 11 mg mg NNP cord-015306-us58wwmp 1800 12 / / SYM cord-015306-us58wwmp 1800 13 m m NN cord-015306-us58wwmp 1800 14 2 2 CD cord-015306-us58wwmp 1800 15 per per IN cord-015306-us58wwmp 1800 16 hour hour NN cord-015306-us58wwmp 1800 17 or or CC cord-015306-us58wwmp 1800 18 a a DT cord-015306-us58wwmp 1800 19 protein protein NN cord-015306-us58wwmp 1800 20 / / SYM cord-015306-us58wwmp 1800 21 creatinine creatinine NN cord-015306-us58wwmp 1800 22 ratio ratio NN cord-015306-us58wwmp 1800 23 below below IN cord-015306-us58wwmp 1800 24 0.2 0.2 CD cord-015306-us58wwmp 1800 25 mg mg NNP cord-015306-us58wwmp 1800 26 / / SYM cord-015306-us58wwmp 1800 27 mg mg NNP cord-015306-us58wwmp 1800 28 for for IN cord-015306-us58wwmp 1800 29 three three CD cord-015306-us58wwmp 1800 30 consecutive consecutive JJ cord-015306-us58wwmp 1800 31 days day NNS cord-015306-us58wwmp 1800 32 . . . cord-015306-us58wwmp 1801 1 Steroid steroid NN cord-015306-us58wwmp 1801 2 resistance resistance NN cord-015306-us58wwmp 1801 3 was be VBD cord-015306-us58wwmp 1801 4 accepted accept VBN cord-015306-us58wwmp 1801 5 as as IN cord-015306-us58wwmp 1801 6 no no DT cord-015306-us58wwmp 1801 7 achievement achievement NN cord-015306-us58wwmp 1801 8 of of IN cord-015306-us58wwmp 1801 9 remission remission NN cord-015306-us58wwmp 1801 10 in in IN cord-015306-us58wwmp 1801 11 spite spite NN cord-015306-us58wwmp 1801 12 of of IN cord-015306-us58wwmp 1801 13 treatment treatment NN cord-015306-us58wwmp 1801 14 with with IN cord-015306-us58wwmp 1801 15 prednisolone prednisolone NNP cord-015306-us58wwmp 1801 16 , , , cord-015306-us58wwmp 1801 17 2 2 CD cord-015306-us58wwmp 1801 18 mg mg NNP cord-015306-us58wwmp 1801 19 / / SYM cord-015306-us58wwmp 1801 20 kg kg NN cord-015306-us58wwmp 1801 21 per per IN cord-015306-us58wwmp 1801 22 day day NN cord-015306-us58wwmp 1801 23 for for IN cord-015306-us58wwmp 1801 24 4 4 CD cord-015306-us58wwmp 1801 25 weeks week NNS cord-015306-us58wwmp 1801 26 . . . cord-015306-us58wwmp 1802 1 If if IN cord-015306-us58wwmp 1802 2 steroid steroid NN cord-015306-us58wwmp 1802 3 resistance resistance NN cord-015306-us58wwmp 1802 4 was be VBD cord-015306-us58wwmp 1802 5 seen see VBN cord-015306-us58wwmp 1802 6 , , , cord-015306-us58wwmp 1802 7 patients patient NNS cord-015306-us58wwmp 1802 8 were be VBD cord-015306-us58wwmp 1802 9 also also RB cord-015306-us58wwmp 1802 10 treated treat VBN cord-015306-us58wwmp 1802 11 with with IN cord-015306-us58wwmp 1802 12 cyclosporine cyclosporine NN cord-015306-us58wwmp 1802 13 A a NN cord-015306-us58wwmp 1802 14 ( ( -LRB- cord-015306-us58wwmp 1802 15 CsA csa NN cord-015306-us58wwmp 1802 16 ) ) -RRB- cord-015306-us58wwmp 1802 17 ( ( -LRB- cord-015306-us58wwmp 1802 18 3 3 CD cord-015306-us58wwmp 1802 19 - - SYM cord-015306-us58wwmp 1802 20 5mg 5mg NN cord-015306-us58wwmp 1802 21 / / SYM cord-015306-us58wwmp 1802 22 kg kg NN cord-015306-us58wwmp 1802 23 per per IN cord-015306-us58wwmp 1802 24 day day NN cord-015306-us58wwmp 1802 25 for for IN cord-015306-us58wwmp 1802 26 least least JJS cord-015306-us58wwmp 1802 27 6 6 CD cord-015306-us58wwmp 1802 28 months month NNS cord-015306-us58wwmp 1802 29 ) ) -RRB- cord-015306-us58wwmp 1802 30 and and CC cord-015306-us58wwmp 1802 31 , , , cord-015306-us58wwmp 1802 32 thereafter thereafter RB cord-015306-us58wwmp 1802 33 , , , cord-015306-us58wwmp 1802 34 if if IN cord-015306-us58wwmp 1802 35 required require VBN cord-015306-us58wwmp 1802 36 , , , cord-015306-us58wwmp 1802 37 with with IN cord-015306-us58wwmp 1802 38 cyclophosphamide(CP cyclophosphamide(cp FW cord-015306-us58wwmp 1802 39 ) ) -RRB- cord-015306-us58wwmp 1803 1 ( ( -LRB- cord-015306-us58wwmp 1803 2 2.5 2.5 CD cord-015306-us58wwmp 1803 3 - - SYM cord-015306-us58wwmp 1803 4 3.0 3.0 CD cord-015306-us58wwmp 1803 5 mg mg NNP cord-015306-us58wwmp 1803 6 / / SYM cord-015306-us58wwmp 1803 7 kg kg NN cord-015306-us58wwmp 1803 8 per per IN cord-015306-us58wwmp 1803 9 day day NN cord-015306-us58wwmp 1803 10 for for IN cord-015306-us58wwmp 1803 11 10 10 CD cord-015306-us58wwmp 1803 12 - - SYM cord-015306-us58wwmp 1803 13 12 12 CD cord-015306-us58wwmp 1803 14 weeks week NNS cord-015306-us58wwmp 1803 15 ) ) -RRB- cord-015306-us58wwmp 1803 16 . . . cord-015306-us58wwmp 1804 1 Renal renal JJ cord-015306-us58wwmp 1804 2 failure failure NN cord-015306-us58wwmp 1804 3 was be VBD cord-015306-us58wwmp 1804 4 defined define VBN cord-015306-us58wwmp 1804 5 as as IN cord-015306-us58wwmp 1804 6 a a DT cord-015306-us58wwmp 1804 7 glomerular glomerular JJ cord-015306-us58wwmp 1804 8 filtration filtration NN cord-015306-us58wwmp 1804 9 rate rate NN cord-015306-us58wwmp 1804 10 ( ( -LRB- cord-015306-us58wwmp 1804 11 GFR GFR NNP cord-015306-us58wwmp 1804 12 ) ) -RRB- cord-015306-us58wwmp 1804 13 below below IN cord-015306-us58wwmp 1804 14 80 80 CD cord-015306-us58wwmp 1804 15 ml ml NN cord-015306-us58wwmp 1804 16 / / SYM cord-015306-us58wwmp 1804 17 min min NN cord-015306-us58wwmp 1804 18 per per IN cord-015306-us58wwmp 1804 19 1.73 1.73 CD cord-015306-us58wwmp 1804 20 m m CD cord-015306-us58wwmp 1804 21 2 2 CD cord-015306-us58wwmp 1804 22 body body NN cord-015306-us58wwmp 1804 23 surface surface NN cord-015306-us58wwmp 1804 24 area area NN cord-015306-us58wwmp 1804 25 , , , cord-015306-us58wwmp 1804 26 and and CC cord-015306-us58wwmp 1804 27 ESRD ESRD NNP cord-015306-us58wwmp 1804 28 was be VBD cord-015306-us58wwmp 1804 29 defined define VBN cord-015306-us58wwmp 1804 30 as as IN cord-015306-us58wwmp 1804 31 a a DT cord-015306-us58wwmp 1804 32 GFR GFR NNP cord-015306-us58wwmp 1804 33 below below IN cord-015306-us58wwmp 1804 34 10 10 CD cord-015306-us58wwmp 1804 35 ml ml NNS cord-015306-us58wwmp 1804 36 / / SYM cord-015306-us58wwmp 1804 37 min min NN cord-015306-us58wwmp 1804 38 per per IN cord-015306-us58wwmp 1804 39 1.73 1.73 CD cord-015306-us58wwmp 1804 40 m m CD cord-015306-us58wwmp 1804 41 2 2 CD cord-015306-us58wwmp 1804 42 or or CC cord-015306-us58wwmp 1804 43 the the DT cord-015306-us58wwmp 1804 44 necessity necessity NN cord-015306-us58wwmp 1804 45 for for IN cord-015306-us58wwmp 1804 46 any any DT cord-015306-us58wwmp 1804 47 renal renal JJ cord-015306-us58wwmp 1804 48 replacement replacement NN cord-015306-us58wwmp 1804 49 therapy therapy NN cord-015306-us58wwmp 1804 50 . . . cord-015306-us58wwmp 1805 1 Bidirectional bidirectional JJ cord-015306-us58wwmp 1805 2 DNA dna NN cord-015306-us58wwmp 1805 3 cycle cycle NN cord-015306-us58wwmp 1805 4 sequencing sequencing NN cord-015306-us58wwmp 1805 5 analysis analysis NN cord-015306-us58wwmp 1805 6 of of IN cord-015306-us58wwmp 1805 7 entire entire JJ cord-015306-us58wwmp 1805 8 coding coding NN cord-015306-us58wwmp 1805 9 exons exon NNS cord-015306-us58wwmp 1805 10 and and CC cord-015306-us58wwmp 1805 11 adjacent adjacent JJ cord-015306-us58wwmp 1805 12 intronic intronic JJ cord-015306-us58wwmp 1805 13 segments segment NNS cord-015306-us58wwmp 1805 14 of of IN cord-015306-us58wwmp 1805 15 NPHS2 nphs2 JJ cord-015306-us58wwmp 1805 16 gene gene NN cord-015306-us58wwmp 1805 17 was be VBD cord-015306-us58wwmp 1805 18 performed perform VBN cord-015306-us58wwmp 1805 19 . . . cord-015306-us58wwmp 1806 1 NPHS2 nphs2 RB cord-015306-us58wwmp 1807 1 gene gene NNP cord-015306-us58wwmp 1807 2 mutation mutation NN cord-015306-us58wwmp 1807 3 analysis analysis NN cord-015306-us58wwmp 1807 4 has have VBZ cord-015306-us58wwmp 1807 5 been be VBN cord-015306-us58wwmp 1807 6 also also RB cord-015306-us58wwmp 1807 7 performed perform VBN cord-015306-us58wwmp 1807 8 in in IN cord-015306-us58wwmp 1807 9 100 100 CD cord-015306-us58wwmp 1807 10 healthy healthy JJ cord-015306-us58wwmp 1807 11 children child NNS cord-015306-us58wwmp 1807 12 . . . cord-015306-us58wwmp 1808 1 Results result NNS cord-015306-us58wwmp 1808 2 : : : cord-015306-us58wwmp 1809 1 Pathogenic pathogenic JJ cord-015306-us58wwmp 1809 2 NPHS2 NPHS2 NNP cord-015306-us58wwmp 1809 3 mutations mutation NNS cord-015306-us58wwmp 1809 4 were be VBD cord-015306-us58wwmp 1809 5 found find VBN cord-015306-us58wwmp 1809 6 in in IN cord-015306-us58wwmp 1809 7 127 127 CD cord-015306-us58wwmp 1809 8 patients patient NNS cord-015306-us58wwmp 1809 9 ( ( -LRB- cord-015306-us58wwmp 1809 10 18 18 CD cord-015306-us58wwmp 1809 11 % % NN cord-015306-us58wwmp 1809 12 ) ) -RRB- cord-015306-us58wwmp 1809 13 from from IN cord-015306-us58wwmp 1809 14 the the DT cord-015306-us58wwmp 1809 15 totally totally RB cord-015306-us58wwmp 1809 16 700 700 CD cord-015306-us58wwmp 1809 17 SRNS SRNS NNP cord-015306-us58wwmp 1809 18 children child NNS cord-015306-us58wwmp 1809 19 group group NN cord-015306-us58wwmp 1809 20 . . . cord-015306-us58wwmp 1810 1 Mutation mutation NN cord-015306-us58wwmp 1810 2 rate rate NN cord-015306-us58wwmp 1810 3 was be VBD cord-015306-us58wwmp 1810 4 29 29 CD cord-015306-us58wwmp 1810 5 % % NN cord-015306-us58wwmp 1810 6 in in IN cord-015306-us58wwmp 1810 7 familial familial JJ cord-015306-us58wwmp 1810 8 group group NN cord-015306-us58wwmp 1810 9 , , , cord-015306-us58wwmp 1810 10 and and CC cord-015306-us58wwmp 1810 11 16.5 16.5 CD cord-015306-us58wwmp 1810 12 % % NN cord-015306-us58wwmp 1810 13 in in IN cord-015306-us58wwmp 1810 14 sporadic sporadic JJ cord-015306-us58wwmp 1810 15 group group NN cord-015306-us58wwmp 1810 16 . . . cord-015306-us58wwmp 1811 1 A a DT cord-015306-us58wwmp 1811 2 total total NN cord-015306-us58wwmp 1811 3 of of IN cord-015306-us58wwmp 1811 4 53 53 CD cord-015306-us58wwmp 1811 5 mutations mutation NNS cord-015306-us58wwmp 1811 6 were be VBD cord-015306-us58wwmp 1811 7 determined determine VBN cord-015306-us58wwmp 1811 8 in in IN cord-015306-us58wwmp 1811 9 the the DT cord-015306-us58wwmp 1811 10 NPHS2 NPHS2 NNP cord-015306-us58wwmp 1811 11 gene gene NN cord-015306-us58wwmp 1811 12 , , , cord-015306-us58wwmp 1811 13 and and CC cord-015306-us58wwmp 1811 14 37 37 CD cord-015306-us58wwmp 1811 15 of of IN cord-015306-us58wwmp 1811 16 which which WDT cord-015306-us58wwmp 1811 17 were be VBD cord-015306-us58wwmp 1811 18 characterized characterize VBN cord-015306-us58wwmp 1811 19 as as IN cord-015306-us58wwmp 1811 20 a a DT cord-015306-us58wwmp 1811 21 novel novel JJ cord-015306-us58wwmp 1811 22 mutation mutation NN cord-015306-us58wwmp 1811 23 presented present VBN cord-015306-us58wwmp 1811 24 at at IN cord-015306-us58wwmp 1811 25 HGMD HGMD NNP cord-015306-us58wwmp 1811 26 databank databank NN cord-015306-us58wwmp 1811 27 . . . cord-015306-us58wwmp 1812 1 In in IN cord-015306-us58wwmp 1812 2 the the DT cord-015306-us58wwmp 1812 3 mutation mutation NN cord-015306-us58wwmp 1812 4 positive positive JJ cord-015306-us58wwmp 1812 5 NPHS2 NPHS2 NNP cord-015306-us58wwmp 1812 6 group group NN cord-015306-us58wwmp 1812 7 , , , cord-015306-us58wwmp 1812 8 most most JJS cord-015306-us58wwmp 1812 9 of of IN cord-015306-us58wwmp 1812 10 the the DT cord-015306-us58wwmp 1812 11 mutations mutation NNS cord-015306-us58wwmp 1812 12 were be VBD cord-015306-us58wwmp 1812 13 found find VBN cord-015306-us58wwmp 1812 14 out out RP cord-015306-us58wwmp 1812 15 to to TO cord-015306-us58wwmp 1812 16 harbor harbor VB cord-015306-us58wwmp 1812 17 in in IN cord-015306-us58wwmp 1812 18 exons exon NNS cord-015306-us58wwmp 1812 19 1 1 CD cord-015306-us58wwmp 1812 20 , , , cord-015306-us58wwmp 1812 21 4 4 CD cord-015306-us58wwmp 1812 22 , , , cord-015306-us58wwmp 1812 23 and and CC cord-015306-us58wwmp 1812 24 5 5 CD cord-015306-us58wwmp 1812 25 while while IN cord-015306-us58wwmp 1812 26 no no DT cord-015306-us58wwmp 1812 27 mutation mutation NN cord-015306-us58wwmp 1812 28 were be VBD cord-015306-us58wwmp 1812 29 found find VBN cord-015306-us58wwmp 1812 30 in in IN cord-015306-us58wwmp 1812 31 exon exon NN cord-015306-us58wwmp 1812 32 6 6 CD cord-015306-us58wwmp 1812 33 of of IN cord-015306-us58wwmp 1812 34 the the DT cord-015306-us58wwmp 1812 35 respective respective JJ cord-015306-us58wwmp 1812 36 gene gene NN cord-015306-us58wwmp 1812 37 . . . cord-015306-us58wwmp 1813 1 Patients patient NNS cord-015306-us58wwmp 1813 2 with with IN cord-015306-us58wwmp 1813 3 P118L P118L NNP cord-015306-us58wwmp 1813 4 , , , cord-015306-us58wwmp 1813 5 R138Q r138q NN cord-015306-us58wwmp 1813 6 , , , cord-015306-us58wwmp 1813 7 R138X R138X NNP cord-015306-us58wwmp 1813 8 , , , cord-015306-us58wwmp 1813 9 R168H r168h NN cord-015306-us58wwmp 1813 10 , , , cord-015306-us58wwmp 1813 11 S211A S211A NNP cord-015306-us58wwmp 1813 12 , , , cord-015306-us58wwmp 1813 13 A212 A212 NNP cord-015306-us58wwmp 1813 14 T T NNP cord-015306-us58wwmp 1813 15 , , , cord-015306-us58wwmp 1813 16 V218 V218 NNP cord-015306-us58wwmp 1813 17 G G NNP cord-015306-us58wwmp 1813 18 , , , cord-015306-us58wwmp 1813 19 H228D H228D NNP cord-015306-us58wwmp 1813 20 , , , cord-015306-us58wwmp 1813 21 IVS7 IVS7 NNP cord-015306-us58wwmp 1813 22 + + SYM cord-015306-us58wwmp 1813 23 5 5 CD cord-015306-us58wwmp 1813 24 G g NN cord-015306-us58wwmp 1814 1 > > XX cord-015306-us58wwmp 1815 1 A a LS cord-015306-us58wwmp 1815 2 , , , cord-015306-us58wwmp 1815 3 c.460 c.460 NNP cord-015306-us58wwmp 1815 4 - - HYPH cord-015306-us58wwmp 1815 5 467insT 467inst CD cord-015306-us58wwmp 1815 6 , , , cord-015306-us58wwmp 1816 1 c.503delG c.503delg CD cord-015306-us58wwmp 1816 2 mutations mutation NNS cord-015306-us58wwmp 1816 3 were be VBD cord-015306-us58wwmp 1816 4 progressed progress VBN cord-015306-us58wwmp 1816 5 to to TO cord-015306-us58wwmp 1816 6 end end VB cord-015306-us58wwmp 1816 7 - - HYPH cord-015306-us58wwmp 1816 8 stage stage NN cord-015306-us58wwmp 1816 9 renal renal JJ cord-015306-us58wwmp 1816 10 disease disease NN cord-015306-us58wwmp 1816 11 ( ( -LRB- cord-015306-us58wwmp 1816 12 ESRD ESRD NNP cord-015306-us58wwmp 1816 13 ) ) -RRB- cord-015306-us58wwmp 1816 14 . . . cord-015306-us58wwmp 1817 1 Also also RB cord-015306-us58wwmp 1817 2 , , , cord-015306-us58wwmp 1817 3 age age NN cord-015306-us58wwmp 1817 4 at at IN cord-015306-us58wwmp 1817 5 onset onset NN cord-015306-us58wwmp 1817 6 of of IN cord-015306-us58wwmp 1817 7 proteinuria proteinuria NN cord-015306-us58wwmp 1817 8 ( ( -LRB- cord-015306-us58wwmp 1817 9 years year NNS cord-015306-us58wwmp 1817 10 ) ) -RRB- cord-015306-us58wwmp 1817 11 was be VBD cord-015306-us58wwmp 1817 12 4.2+/-0.5 4.2+/-0.5 CD cord-015306-us58wwmp 1817 13 in in IN cord-015306-us58wwmp 1817 14 the the DT cord-015306-us58wwmp 1817 15 mutation mutation NN cord-015306-us58wwmp 1817 16 ( ( -LRB- cord-015306-us58wwmp 1817 17 - - : cord-015306-us58wwmp 1817 18 ) ) -RRB- cord-015306-us58wwmp 1817 19 ( ( -LRB- cord-015306-us58wwmp 1817 20 n=573 n=573 UH cord-015306-us58wwmp 1817 21 ) ) -RRB- cord-015306-us58wwmp 1817 22 group group NN cord-015306-us58wwmp 1817 23 ; ; : cord-015306-us58wwmp 1817 24 3.6+/-3.08 3.6+/-3.08 CD cord-015306-us58wwmp 1817 25 in in IN cord-015306-us58wwmp 1817 26 the the DT cord-015306-us58wwmp 1817 27 mutation mutation NN cord-015306-us58wwmp 1817 28 ( ( -LRB- cord-015306-us58wwmp 1817 29 + + NN cord-015306-us58wwmp 1817 30 ) ) -RRB- cord-015306-us58wwmp 1818 1 ( ( -LRB- cord-015306-us58wwmp 1818 2 n=127 n=127 NNP cord-015306-us58wwmp 1818 3 ) ) -RRB- cord-015306-us58wwmp 1818 4 group group NN cord-015306-us58wwmp 1818 5 . . . cord-015306-us58wwmp 1819 1 For for IN cord-015306-us58wwmp 1819 2 the the DT cord-015306-us58wwmp 1819 3 mutation mutation NN cord-015306-us58wwmp 1819 4 negative negative JJ cord-015306-us58wwmp 1819 5 patients patient NNS cord-015306-us58wwmp 1819 6 , , , cord-015306-us58wwmp 1819 7 effects effect NNS cord-015306-us58wwmp 1819 8 of of IN cord-015306-us58wwmp 1819 9 other other JJ cord-015306-us58wwmp 1819 10 disease disease NN cord-015306-us58wwmp 1819 11 causing cause VBG cord-015306-us58wwmp 1819 12 genes gene NNS cord-015306-us58wwmp 1819 13 involving involve VBG cord-015306-us58wwmp 1819 14 NPHS1 nphs1 XX cord-015306-us58wwmp 1819 15 , , , cord-015306-us58wwmp 1819 16 WT1 WT1 NNP cord-015306-us58wwmp 1819 17 , , , cord-015306-us58wwmp 1819 18 TRPC6 TRPC6 NNP cord-015306-us58wwmp 1819 19 , , , cord-015306-us58wwmp 1819 20 CD2AP CD2AP NNP cord-015306-us58wwmp 1819 21 , , , cord-015306-us58wwmp 1819 22 and and CC cord-015306-us58wwmp 1819 23 ACTN4 ACTN4 VBN cord-015306-us58wwmp 1819 24 for for IN cord-015306-us58wwmp 1819 25 different different JJ cord-015306-us58wwmp 1819 26 molecular molecular JJ cord-015306-us58wwmp 1819 27 subtypes subtype NNS cord-015306-us58wwmp 1819 28 of of IN cord-015306-us58wwmp 1819 29 SRNS SRNS NNP cord-015306-us58wwmp 1819 30 may may MD cord-015306-us58wwmp 1819 31 be be VB cord-015306-us58wwmp 1819 32 considered consider VBN cord-015306-us58wwmp 1819 33 . . . cord-015306-us58wwmp 1820 1 NPHS1 NPHS1 NNP cord-015306-us58wwmp 1820 2 mutation mutation NN cord-015306-us58wwmp 1820 3 screening screening NN cord-015306-us58wwmp 1820 4 was be VBD cord-015306-us58wwmp 1820 5 performed perform VBN cord-015306-us58wwmp 1820 6 for for IN cord-015306-us58wwmp 1820 7 all all PDT cord-015306-us58wwmp 1820 8 the the DT cord-015306-us58wwmp 1820 9 patients patient NNS cord-015306-us58wwmp 1820 10 who who WP cord-015306-us58wwmp 1820 11 had have VBD cord-015306-us58wwmp 1820 12 proteinuria proteinuria NN cord-015306-us58wwmp 1820 13 up up RP cord-015306-us58wwmp 1820 14 to to TO cord-015306-us58wwmp 1820 15 two two CD cord-015306-us58wwmp 1820 16 years year NNS cord-015306-us58wwmp 1820 17 of of IN cord-015306-us58wwmp 1820 18 age age NN cord-015306-us58wwmp 1820 19 . . . cord-015306-us58wwmp 1821 1 As as IN cord-015306-us58wwmp 1821 2 a a DT cord-015306-us58wwmp 1821 3 causative causative JJ cord-015306-us58wwmp 1821 4 SRNS SRNS NNP cord-015306-us58wwmp 1821 5 gene gene NN cord-015306-us58wwmp 1821 6 , , , cord-015306-us58wwmp 1821 7 we -PRON- PRP cord-015306-us58wwmp 1821 8 should should MD cord-015306-us58wwmp 1821 9 consider consider VB cord-015306-us58wwmp 1821 10 NPHS2 NPHS2 NNP cord-015306-us58wwmp 1821 11 gene gene NN cord-015306-us58wwmp 1821 12 mutation mutation NN cord-015306-us58wwmp 1821 13 screening screening NN cord-015306-us58wwmp 1821 14 in in IN cord-015306-us58wwmp 1821 15 early early JJ cord-015306-us58wwmp 1821 16 diagnosis diagnosis NN cord-015306-us58wwmp 1821 17 and and CC cord-015306-us58wwmp 1821 18 the the DT cord-015306-us58wwmp 1821 19 follow follow NN cord-015306-us58wwmp 1821 20 - - HYPH cord-015306-us58wwmp 1821 21 up up NN cord-015306-us58wwmp 1821 22 of of IN cord-015306-us58wwmp 1821 23 the the DT cord-015306-us58wwmp 1821 24 clinical clinical JJ cord-015306-us58wwmp 1821 25 course course NN cord-015306-us58wwmp 1821 26 . . . cord-015306-us58wwmp 1822 1 Conclusion conclusion NN cord-015306-us58wwmp 1822 2 : : : cord-015306-us58wwmp 1823 1 In in IN cord-015306-us58wwmp 1823 2 relation relation NN cord-015306-us58wwmp 1823 3 to to IN cord-015306-us58wwmp 1823 4 homozygous homozygous JJ cord-015306-us58wwmp 1823 5 or or CC cord-015306-us58wwmp 1823 6 compound compound JJ cord-015306-us58wwmp 1823 7 heterozygous heterozygous JJ cord-015306-us58wwmp 1823 8 NPHS2 nphs2 RB cord-015306-us58wwmp 1823 9 mutated mutated JJ cord-015306-us58wwmp 1823 10 patients patient NNS cord-015306-us58wwmp 1823 11 who who WP cord-015306-us58wwmp 1823 12 have have VBP cord-015306-us58wwmp 1823 13 the the DT cord-015306-us58wwmp 1823 14 lack lack NN cord-015306-us58wwmp 1823 15 of of IN cord-015306-us58wwmp 1823 16 response response NN cord-015306-us58wwmp 1823 17 to to IN cord-015306-us58wwmp 1823 18 standard standard JJ cord-015306-us58wwmp 1823 19 steroid steroid NN cord-015306-us58wwmp 1823 20 therapy therapy NN cord-015306-us58wwmp 1823 21 we -PRON- PRP cord-015306-us58wwmp 1823 22 suggest suggest VBP cord-015306-us58wwmp 1823 23 to to TO cord-015306-us58wwmp 1823 24 perform perform VB cord-015306-us58wwmp 1823 25 NPHS2 NPHS2 NNP cord-015306-us58wwmp 1823 26 gene gene NN cord-015306-us58wwmp 1823 27 mutation mutation NN cord-015306-us58wwmp 1823 28 analysis analysis NN cord-015306-us58wwmp 1823 29 for for IN cord-015306-us58wwmp 1823 30 every every DT cord-015306-us58wwmp 1823 31 child child NN cord-015306-us58wwmp 1823 32 ( ( -LRB- cord-015306-us58wwmp 1823 33 if if IN cord-015306-us58wwmp 1823 34 consent consent NN cord-015306-us58wwmp 1823 35 can can MD cord-015306-us58wwmp 1823 36 be be VB cord-015306-us58wwmp 1823 37 obtained obtain VBN cord-015306-us58wwmp 1823 38 ) ) -RRB- cord-015306-us58wwmp 1823 39 soon soon RB cord-015306-us58wwmp 1823 40 after after IN cord-015306-us58wwmp 1823 41 the the DT cord-015306-us58wwmp 1823 42 first first JJ cord-015306-us58wwmp 1823 43 episode episode NN cord-015306-us58wwmp 1823 44 of of IN cord-015306-us58wwmp 1823 45 NS NS NNP cord-015306-us58wwmp 1823 46 . . . cord-015306-us58wwmp 1824 1 For for IN cord-015306-us58wwmp 1824 2 the the DT cord-015306-us58wwmp 1824 3 newly newly RB cord-015306-us58wwmp 1824 4 diagnosed diagnose VBN cord-015306-us58wwmp 1824 5 patients patient NNS cord-015306-us58wwmp 1824 6 , , , cord-015306-us58wwmp 1824 7 the the DT cord-015306-us58wwmp 1824 8 crucial crucial JJ cord-015306-us58wwmp 1824 9 certain certain JJ cord-015306-us58wwmp 1824 10 determination determination NN cord-015306-us58wwmp 1824 11 of of IN cord-015306-us58wwmp 1824 12 the the DT cord-015306-us58wwmp 1824 13 causative causative JJ cord-015306-us58wwmp 1824 14 disease disease NN cord-015306-us58wwmp 1824 15 gene gene NN cord-015306-us58wwmp 1824 16 mutation mutation NN cord-015306-us58wwmp 1824 17 will will MD cord-015306-us58wwmp 1824 18 enable enable VB cord-015306-us58wwmp 1824 19 clinicians clinician NNS cord-015306-us58wwmp 1824 20 to to TO cord-015306-us58wwmp 1824 21 avoid avoid VB cord-015306-us58wwmp 1824 22 redundant redundant JJ cord-015306-us58wwmp 1824 23 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 1824 24 therapeutic therapeutic JJ cord-015306-us58wwmp 1824 25 trials trial NNS cord-015306-us58wwmp 1824 26 . . . cord-015306-us58wwmp 1825 1 We -PRON- PRP cord-015306-us58wwmp 1825 2 then then RB cord-015306-us58wwmp 1825 3 performed perform VBD cord-015306-us58wwmp 1825 4 Next Next NNP cord-015306-us58wwmp 1825 5 Generation Generation NNP cord-015306-us58wwmp 1825 6 Sequencing Sequencing NNP cord-015306-us58wwmp 1825 7 in in IN cord-015306-us58wwmp 1825 8 the the DT cord-015306-us58wwmp 1825 9 5 5 CD cord-015306-us58wwmp 1825 10 affected affected JJ cord-015306-us58wwmp 1825 11 patients patient NNS cord-015306-us58wwmp 1825 12 and and CC cord-015306-us58wwmp 1825 13 in in IN cord-015306-us58wwmp 1825 14 one one CD cord-015306-us58wwmp 1825 15 of of IN cord-015306-us58wwmp 1825 16 their -PRON- PRP$ cord-015306-us58wwmp 1825 17 unaffected unaffected JJ cord-015306-us58wwmp 1825 18 relatives relative NNS cord-015306-us58wwmp 1825 19 . . . cord-015306-us58wwmp 1826 1 Exome Exome NNP cord-015306-us58wwmp 1826 2 enrichment enrichment NN cord-015306-us58wwmp 1826 3 was be VBD cord-015306-us58wwmp 1826 4 conducted conduct VBN cord-015306-us58wwmp 1826 5 using use VBG cord-015306-us58wwmp 1826 6 the the DT cord-015306-us58wwmp 1826 7 Agilent Agilent NNP cord-015306-us58wwmp 1826 8 SureSelect SureSelect NNP cord-015306-us58wwmp 1826 9 Human Human NNP cord-015306-us58wwmp 1826 10 All all DT cord-015306-us58wwmp 1826 11 Exon Exon NNP cord-015306-us58wwmp 1826 12 V4 V4 NNP cord-015306-us58wwmp 1826 13 + + CC cord-015306-us58wwmp 1826 14 UTRs UTRs NNP cord-015306-us58wwmp 1826 15 capture capture NN cord-015306-us58wwmp 1826 16 kit kit NN cord-015306-us58wwmp 1826 17 . . . cord-015306-us58wwmp 1827 1 The the DT cord-015306-us58wwmp 1827 2 multiplex multiplex NN cord-015306-us58wwmp 1827 3 libraries library NNS cord-015306-us58wwmp 1827 4 were be VBD cord-015306-us58wwmp 1827 5 then then RB cord-015306-us58wwmp 1827 6 sequenced sequence VBN cord-015306-us58wwmp 1827 7 on on IN cord-015306-us58wwmp 1827 8 an an DT cord-015306-us58wwmp 1827 9 Illumina Illumina NNP cord-015306-us58wwmp 1827 10 HiSeq2000 HiSeq2000 NNP cord-015306-us58wwmp 1827 11 instrument instrument NN cord-015306-us58wwmp 1827 12 with with IN cord-015306-us58wwmp 1827 13 a a DT cord-015306-us58wwmp 1827 14 2x76 2x76 CD cord-015306-us58wwmp 1827 15 bp bp NNP cord-015306-us58wwmp 1827 16 read read VBD cord-015306-us58wwmp 1827 17 length length NN cord-015306-us58wwmp 1827 18 . . . cord-015306-us58wwmp 1828 1 Results result NNS cord-015306-us58wwmp 1828 2 : : : cord-015306-us58wwmp 1829 1 We -PRON- PRP cord-015306-us58wwmp 1829 2 unexpectedly unexpectedly RB cord-015306-us58wwmp 1829 3 identified identify VBD cord-015306-us58wwmp 1829 4 a a DT cord-015306-us58wwmp 1829 5 novel novel JJ cord-015306-us58wwmp 1829 6 LMX1B lmx1b NN cord-015306-us58wwmp 1829 7 mutation mutation NN cord-015306-us58wwmp 1829 8 segregating segregate VBG cord-015306-us58wwmp 1829 9 with with IN cord-015306-us58wwmp 1829 10 the the DT cord-015306-us58wwmp 1829 11 disease disease NN cord-015306-us58wwmp 1829 12 in in IN cord-015306-us58wwmp 1829 13 the the DT cord-015306-us58wwmp 1829 14 family family NN cord-015306-us58wwmp 1829 15 . . . cord-015306-us58wwmp 1830 1 Subsequently subsequently RB cord-015306-us58wwmp 1830 2 , , , cord-015306-us58wwmp 1830 3 we -PRON- PRP cord-015306-us58wwmp 1830 4 screened screen VBD cord-015306-us58wwmp 1830 5 74 74 CD cord-015306-us58wwmp 1830 6 additional additional JJ cord-015306-us58wwmp 1830 7 unrelated unrelated JJ cord-015306-us58wwmp 1830 8 families family NNS cord-015306-us58wwmp 1830 9 from from IN cord-015306-us58wwmp 1830 10 our -PRON- PRP$ cord-015306-us58wwmp 1830 11 international international JJ cord-015306-us58wwmp 1830 12 cohort cohort NN cord-015306-us58wwmp 1830 13 of of IN cord-015306-us58wwmp 1830 14 autosomal autosomal JJ cord-015306-us58wwmp 1830 15 dominant dominant JJ cord-015306-us58wwmp 1830 16 FSGS FSGS NNP cord-015306-us58wwmp 1830 17 and and CC cord-015306-us58wwmp 1830 18 found find VBD cord-015306-us58wwmp 1830 19 mutations mutation NNS cord-015306-us58wwmp 1830 20 of of IN cord-015306-us58wwmp 1830 21 the the DT cord-015306-us58wwmp 1830 22 same same JJ cord-015306-us58wwmp 1830 23 residue residue NN cord-015306-us58wwmp 1830 24 in in IN cord-015306-us58wwmp 1830 25 2 2 CD cord-015306-us58wwmp 1830 26 families family NNS cord-015306-us58wwmp 1830 27 . . . cord-015306-us58wwmp 1831 1 None none NN cord-015306-us58wwmp 1831 2 of of IN cord-015306-us58wwmp 1831 3 the the DT cord-015306-us58wwmp 1831 4 probands proband NNS cord-015306-us58wwmp 1831 5 had have VBD cord-015306-us58wwmp 1831 6 any any DT cord-015306-us58wwmp 1831 7 sign sign NN cord-015306-us58wwmp 1831 8 of of IN cord-015306-us58wwmp 1831 9 dysplasia dysplasia NN cord-015306-us58wwmp 1831 10 of of IN cord-015306-us58wwmp 1831 11 nails nail NNS cord-015306-us58wwmp 1831 12 , , , cord-015306-us58wwmp 1831 13 patellae patella NNS cord-015306-us58wwmp 1831 14 or or CC cord-015306-us58wwmp 1831 15 elbows elbow NNS cord-015306-us58wwmp 1831 16 , , , cord-015306-us58wwmp 1831 17 iliac iliac NN cord-015306-us58wwmp 1831 18 horns horn NNS cord-015306-us58wwmp 1831 19 or or CC cord-015306-us58wwmp 1831 20 glaucoma glaucoma NN cord-015306-us58wwmp 1831 21 , , , cord-015306-us58wwmp 1831 22 or or CC cord-015306-us58wwmp 1831 23 any any DT cord-015306-us58wwmp 1831 24 ultrastructural ultrastructural JJ cord-015306-us58wwmp 1831 25 changes change NNS cord-015306-us58wwmp 1831 26 suggestive suggestive JJ cord-015306-us58wwmp 1831 27 of of IN cord-015306-us58wwmp 1831 28 Nail nail NN cord-015306-us58wwmp 1831 29 - - HYPH cord-015306-us58wwmp 1831 30 Patella patella NN cord-015306-us58wwmp 1831 31 - - HYPH cord-015306-us58wwmp 1831 32 like like JJ cord-015306-us58wwmp 1831 33 renal renal JJ cord-015306-us58wwmp 1831 34 lesions lesion NNS cord-015306-us58wwmp 1831 35 . . . cord-015306-us58wwmp 1832 1 LMX1B LMX1B NNP cord-015306-us58wwmp 1832 2 encodes encode VBZ cord-015306-us58wwmp 1832 3 a a DT cord-015306-us58wwmp 1832 4 homeodomain homeodomain NN cord-015306-us58wwmp 1832 5 - - HYPH cord-015306-us58wwmp 1832 6 containing contain VBG cord-015306-us58wwmp 1832 7 transcription transcription NN cord-015306-us58wwmp 1832 8 factor factor NN cord-015306-us58wwmp 1832 9 that that WDT cord-015306-us58wwmp 1832 10 is be VBZ cord-015306-us58wwmp 1832 11 essential essential JJ cord-015306-us58wwmp 1832 12 during during IN cord-015306-us58wwmp 1832 13 development development NN cord-015306-us58wwmp 1832 14 . . . cord-015306-us58wwmp 1833 1 A a DT cord-015306-us58wwmp 1833 2 LMX1B lmx1b NN cord-015306-us58wwmp 1833 3 in in IN cord-015306-us58wwmp 1833 4 silicohomology silicohomology NN cord-015306-us58wwmp 1833 5 model model NN cord-015306-us58wwmp 1833 6 suggests suggest VBZ cord-015306-us58wwmp 1833 7 the the DT cord-015306-us58wwmp 1833 8 mutated mutated JJ cord-015306-us58wwmp 1833 9 residue residue NN cord-015306-us58wwmp 1833 10 plays play VBZ cord-015306-us58wwmp 1833 11 an an DT cord-015306-us58wwmp 1833 12 important important JJ cord-015306-us58wwmp 1833 13 role role NN cord-015306-us58wwmp 1833 14 in in IN cord-015306-us58wwmp 1833 15 strengthening strengthen VBG cord-015306-us58wwmp 1833 16 the the DT cord-015306-us58wwmp 1833 17 interaction interaction NN cord-015306-us58wwmp 1833 18 between between IN cord-015306-us58wwmp 1833 19 the the DT cord-015306-us58wwmp 1833 20 LMX1B LMX1B NNP cord-015306-us58wwmp 1833 21 homeodomain homeodomain NNP cord-015306-us58wwmp 1833 22 and and CC cord-015306-us58wwmp 1833 23 DNA DNA NNP cord-015306-us58wwmp 1833 24 . . . cord-015306-us58wwmp 1834 1 Both both DT cord-015306-us58wwmp 1834 2 mutations mutation NNS cord-015306-us58wwmp 1834 3 are be VBP cord-015306-us58wwmp 1834 4 expected expect VBN cord-015306-us58wwmp 1834 5 to to TO cord-015306-us58wwmp 1834 6 diminish diminish VB cord-015306-us58wwmp 1834 7 such such JJ cord-015306-us58wwmp 1834 8 interactions interaction NNS cord-015306-us58wwmp 1834 9 . . . cord-015306-us58wwmp 1835 1 Conclusions conclusion NNS cord-015306-us58wwmp 1835 2 : : : cord-015306-us58wwmp 1836 1 Our -PRON- PRP$ cord-015306-us58wwmp 1836 2 data datum NNS cord-015306-us58wwmp 1836 3 demonstrate demonstrate VBP cord-015306-us58wwmp 1836 4 that that IN cord-015306-us58wwmp 1836 5 isolated isolate VBN cord-015306-us58wwmp 1836 6 FSGS FSGS NNP cord-015306-us58wwmp 1836 7 could could MD cord-015306-us58wwmp 1836 8 be be VB cord-015306-us58wwmp 1836 9 due due JJ cord-015306-us58wwmp 1836 10 to to IN cord-015306-us58wwmp 1836 11 mutations mutation NNS cord-015306-us58wwmp 1836 12 in in IN cord-015306-us58wwmp 1836 13 genes gene NNS cord-015306-us58wwmp 1836 14 also also RB cord-015306-us58wwmp 1836 15 involved involve VBN cord-015306-us58wwmp 1836 16 in in IN cord-015306-us58wwmp 1836 17 syndromic syndromic JJ cord-015306-us58wwmp 1836 18 forms form NNS cord-015306-us58wwmp 1836 19 and and CC cord-015306-us58wwmp 1836 20 highlights highlight VBZ cord-015306-us58wwmp 1836 21 the the DT cord-015306-us58wwmp 1836 22 need need NN cord-015306-us58wwmp 1836 23 to to TO cord-015306-us58wwmp 1836 24 include include VB cord-015306-us58wwmp 1836 25 these these DT cord-015306-us58wwmp 1836 26 genes gene NNS cord-015306-us58wwmp 1836 27 in in IN cord-015306-us58wwmp 1836 28 all all DT cord-015306-us58wwmp 1836 29 next next JJ cord-015306-us58wwmp 1836 30 - - HYPH cord-015306-us58wwmp 1836 31 generation generation NN cord-015306-us58wwmp 1836 32 sequencing sequencing NN cord-015306-us58wwmp 1836 33 diagnosis diagnosis NN cord-015306-us58wwmp 1836 34 approaches approach NNS cord-015306-us58wwmp 1836 35 in in IN cord-015306-us58wwmp 1836 36 FSGS FSGS NNP cord-015306-us58wwmp 1836 37 . . . cord-015306-us58wwmp 1837 1 .In .In . cord-015306-us58wwmp 1838 1 24/37 24/37 CD cord-015306-us58wwmp 1838 2 patients patient NNS cord-015306-us58wwmp 1838 3 mutations mutation NNS cord-015306-us58wwmp 1838 4 were be VBD cord-015306-us58wwmp 1838 5 identified identify VBN cord-015306-us58wwmp 1838 6 by by IN cord-015306-us58wwmp 1838 7 NGS NGS NNP cord-015306-us58wwmp 1838 8 ( ( -LRB- cord-015306-us58wwmp 1838 9 detection detection NN cord-015306-us58wwmp 1838 10 rate rate NN cord-015306-us58wwmp 1838 11 65 65 CD cord-015306-us58wwmp 1838 12 % % NN cord-015306-us58wwmp 1838 13 ) ) -RRB- cord-015306-us58wwmp 1838 14 . . . cord-015306-us58wwmp 1839 1 In in IN cord-015306-us58wwmp 1839 2 8/24 8/24 CD cord-015306-us58wwmp 1839 3 patients patient NNS cord-015306-us58wwmp 1839 4 sequence sequence NN cord-015306-us58wwmp 1839 5 variants variant NNS cord-015306-us58wwmp 1839 6 were be VBD cord-015306-us58wwmp 1839 7 found find VBN cord-015306-us58wwmp 1839 8 in in IN cord-015306-us58wwmp 1839 9 two two CD cord-015306-us58wwmp 1839 10 different different JJ cord-015306-us58wwmp 1839 11 genes gene NNS cord-015306-us58wwmp 1839 12 ( ( -LRB- cord-015306-us58wwmp 1839 13 33 33 CD cord-015306-us58wwmp 1839 14 % % NN cord-015306-us58wwmp 1839 15 ) ) -RRB- cord-015306-us58wwmp 1839 16 suggesting suggest VBG cord-015306-us58wwmp 1839 17 oligogenic oligogenic VBN cord-015306-us58wwmp 1839 18 inheritance inheritance NN cord-015306-us58wwmp 1839 19 . . . cord-015306-us58wwmp 1840 1 In in IN cord-015306-us58wwmp 1840 2 6 6 CD cord-015306-us58wwmp 1840 3 of of IN cord-015306-us58wwmp 1840 4 these these DT cord-015306-us58wwmp 1840 5 8 8 CD cord-015306-us58wwmp 1840 6 patients patient NNS cord-015306-us58wwmp 1840 7 the the DT cord-015306-us58wwmp 1840 8 causative causative JJ cord-015306-us58wwmp 1840 9 mutation mutation NN cord-015306-us58wwmp 1840 10 was be VBD cord-015306-us58wwmp 1840 11 located locate VBN cord-015306-us58wwmp 1840 12 in in IN cord-015306-us58wwmp 1840 13 a a DT cord-015306-us58wwmp 1840 14 gene gene NN cord-015306-us58wwmp 1840 15 following follow VBG cord-015306-us58wwmp 1840 16 an an DT cord-015306-us58wwmp 1840 17 autosomal autosomal JJ cord-015306-us58wwmp 1840 18 dominant dominant JJ cord-015306-us58wwmp 1840 19 inheritance inheritance NN cord-015306-us58wwmp 1840 20 pattern pattern NN cord-015306-us58wwmp 1840 21 . . . cord-015306-us58wwmp 1841 1 These these DT cord-015306-us58wwmp 1841 2 patients patient NNS cord-015306-us58wwmp 1841 3 showed show VBD cord-015306-us58wwmp 1841 4 a a DT cord-015306-us58wwmp 1841 5 more more RBR cord-015306-us58wwmp 1841 6 severe severe JJ cord-015306-us58wwmp 1841 7 form form NN cord-015306-us58wwmp 1841 8 of of IN cord-015306-us58wwmp 1841 9 the the DT cord-015306-us58wwmp 1841 10 disease disease NN cord-015306-us58wwmp 1841 11 compared compare VBN cord-015306-us58wwmp 1841 12 to to IN cord-015306-us58wwmp 1841 13 affected affect VBN cord-015306-us58wwmp 1841 14 family family NN cord-015306-us58wwmp 1841 15 members member NNS cord-015306-us58wwmp 1841 16 who who WP cord-015306-us58wwmp 1841 17 showed show VBD cord-015306-us58wwmp 1841 18 only only RB cord-015306-us58wwmp 1841 19 the the DT cord-015306-us58wwmp 1841 20 causative causative JJ cord-015306-us58wwmp 1841 21 mutation mutation NN cord-015306-us58wwmp 1841 22 without without IN cord-015306-us58wwmp 1841 23 additional additional JJ cord-015306-us58wwmp 1841 24 modifier modifier NN cord-015306-us58wwmp 1841 25 variants variant NNS cord-015306-us58wwmp 1841 26 . . . cord-015306-us58wwmp 1842 1 One one CD cord-015306-us58wwmp 1842 2 additional additional JJ cord-015306-us58wwmp 1842 3 patient patient NN cord-015306-us58wwmp 1842 4 of of IN cord-015306-us58wwmp 1842 5 this this DT cord-015306-us58wwmp 1842 6 cohort cohort NN cord-015306-us58wwmp 1842 7 with with IN cord-015306-us58wwmp 1842 8 Pierson Pierson NNP cord-015306-us58wwmp 1842 9 syndrome syndrome NN cord-015306-us58wwmp 1842 10 had have VBD cord-015306-us58wwmp 1842 11 two two CD cord-015306-us58wwmp 1842 12 single single JJ cord-015306-us58wwmp 1842 13 heterozygous heterozygous JJ cord-015306-us58wwmp 1842 14 mutations mutation NNS cord-015306-us58wwmp 1842 15 in in IN cord-015306-us58wwmp 1842 16 NPHS1 NPHS1 NNP cord-015306-us58wwmp 1842 17 and and CC cord-015306-us58wwmp 1842 18 LAMB2 LAMB2 NNP cord-015306-us58wwmp 1842 19 , , , cord-015306-us58wwmp 1842 20 respectively respectively RB cord-015306-us58wwmp 1842 21 ( ( -LRB- cord-015306-us58wwmp 1842 22 both both DT cord-015306-us58wwmp 1842 23 genes gene NNS cord-015306-us58wwmp 1842 24 following follow VBG cord-015306-us58wwmp 1842 25 an an DT cord-015306-us58wwmp 1842 26 autosomal autosomal JJ cord-015306-us58wwmp 1842 27 recessive recessive JJ cord-015306-us58wwmp 1842 28 pattern pattern NN cord-015306-us58wwmp 1842 29 of of IN cord-015306-us58wwmp 1842 30 inheritance inheritance NN cord-015306-us58wwmp 1842 31 ) ) -RRB- cord-015306-us58wwmp 1842 32 . . . cord-015306-us58wwmp 1843 1 A a DT cord-015306-us58wwmp 1843 2 further further JJ cord-015306-us58wwmp 1843 3 patient patient NN cord-015306-us58wwmp 1843 4 showed show VBD cord-015306-us58wwmp 1843 5 two two CD cord-015306-us58wwmp 1843 6 mutations mutation NNS cord-015306-us58wwmp 1843 7 in in IN cord-015306-us58wwmp 1843 8 NPHS1 NPHS1 NNP cord-015306-us58wwmp 1843 9 and and CC cord-015306-us58wwmp 1843 10 the the DT cord-015306-us58wwmp 1843 11 non non JJ cord-015306-us58wwmp 1843 12 - - JJ cord-015306-us58wwmp 1843 13 neutral neutral JJ cord-015306-us58wwmp 1843 14 polymorphism polymorphism NN cord-015306-us58wwmp 1843 15 p. p. NN cord-015306-us58wwmp 1844 1 Arg229Gln arg229gln IN cord-015306-us58wwmp 1844 2 in in IN cord-015306-us58wwmp 1844 3 NPHS2 NPHS2 NNP cord-015306-us58wwmp 1844 4 . . . cord-015306-us58wwmp 1845 1 Structural structural JJ cord-015306-us58wwmp 1845 2 and/or and/or CC cord-015306-us58wwmp 1845 3 functional functional JJ cord-015306-us58wwmp 1845 4 analysis analysis NN cord-015306-us58wwmp 1845 5 of of IN cord-015306-us58wwmp 1845 6 all all DT cord-015306-us58wwmp 1845 7 mutations mutation NNS cord-015306-us58wwmp 1845 8 identified identify VBN cord-015306-us58wwmp 1845 9 in in IN cord-015306-us58wwmp 1845 10 patients patient NNS cord-015306-us58wwmp 1845 11 with with IN cord-015306-us58wwmp 1845 12 mutations mutation NNS cord-015306-us58wwmp 1845 13 in in IN cord-015306-us58wwmp 1845 14 two two CD cord-015306-us58wwmp 1845 15 genes gene NNS cord-015306-us58wwmp 1845 16 suggested suggest VBD cord-015306-us58wwmp 1845 17 impaired impaired JJ cord-015306-us58wwmp 1845 18 protein protein NN cord-015306-us58wwmp 1845 19 function function NN cord-015306-us58wwmp 1845 20 of of IN cord-015306-us58wwmp 1845 21 the the DT cord-015306-us58wwmp 1845 22 particular particular JJ cord-015306-us58wwmp 1845 23 gene gene NN cord-015306-us58wwmp 1845 24 products product NNS cord-015306-us58wwmp 1845 25 . . . cord-015306-us58wwmp 1846 1 Conclusion conclusion NN cord-015306-us58wwmp 1846 2 : : : cord-015306-us58wwmp 1847 1 The the DT cord-015306-us58wwmp 1847 2 influence influence NN cord-015306-us58wwmp 1847 3 of of IN cord-015306-us58wwmp 1847 4 modifier modifier NN cord-015306-us58wwmp 1847 5 genes gene NNS cord-015306-us58wwmp 1847 6 or or CC cord-015306-us58wwmp 1847 7 digenic digenic JJ cord-015306-us58wwmp 1847 8 inheritance inheritance NN cord-015306-us58wwmp 1847 9 seems seem VBZ cord-015306-us58wwmp 1847 10 to to TO cord-015306-us58wwmp 1847 11 play play VB cord-015306-us58wwmp 1847 12 an an DT cord-015306-us58wwmp 1847 13 important important JJ cord-015306-us58wwmp 1847 14 role role NN cord-015306-us58wwmp 1847 15 in in IN cord-015306-us58wwmp 1847 16 the the DT cord-015306-us58wwmp 1847 17 pathogenicity pathogenicity NN cord-015306-us58wwmp 1847 18 of of IN cord-015306-us58wwmp 1847 19 SRNS SRNS NNP cord-015306-us58wwmp 1847 20 . . . cord-015306-us58wwmp 1848 1 The the DT cord-015306-us58wwmp 1848 2 application application NN cord-015306-us58wwmp 1848 3 of of IN cord-015306-us58wwmp 1848 4 NGS NGS NNP cord-015306-us58wwmp 1848 5 is be VBZ cord-015306-us58wwmp 1848 6 therefore therefore RB cord-015306-us58wwmp 1848 7 of of IN cord-015306-us58wwmp 1848 8 special special JJ cord-015306-us58wwmp 1848 9 interest interest NN cord-015306-us58wwmp 1848 10 and and CC cord-015306-us58wwmp 1848 11 highly highly RB cord-015306-us58wwmp 1848 12 efficient efficient JJ cord-015306-us58wwmp 1848 13 in in IN cord-015306-us58wwmp 1848 14 the the DT cord-015306-us58wwmp 1848 15 diagnostics diagnostic NNS cord-015306-us58wwmp 1848 16 of of IN cord-015306-us58wwmp 1848 17 patients patient NNS cord-015306-us58wwmp 1848 18 with with IN cord-015306-us58wwmp 1848 19 SRNS SRNS NNP cord-015306-us58wwmp 1848 20 . . . cord-015306-us58wwmp 1849 1 Abstract abstract JJ cord-015306-us58wwmp 1849 2 # # NN cord-015306-us58wwmp 1849 3 P p NN cord-015306-us58wwmp 1849 4 - - , cord-015306-us58wwmp 1849 5 SAT232 SAT232 NNP cord-015306-us58wwmp 1849 6 Mutation Mutation NNP cord-015306-us58wwmp 1849 7 analysis analysis NN cord-015306-us58wwmp 1849 8 in in IN cord-015306-us58wwmp 1849 9 Japanese japanese JJ cord-015306-us58wwmp 1849 10 patients patient NNS cord-015306-us58wwmp 1849 11 with with IN cord-015306-us58wwmp 1849 12 congenital congenital JJ cord-015306-us58wwmp 1849 13 and and CC cord-015306-us58wwmp 1849 14 infantile infantile JJ cord-015306-us58wwmp 1849 15 nephrotic nephrotic NN cord-015306-us58wwmp 1850 1 syndrome syndrome NNP cord-015306-us58wwmp 1850 2 Objective Objective NNP cord-015306-us58wwmp 1850 3 : : : cord-015306-us58wwmp 1851 1 Mutations mutation NNS cord-015306-us58wwmp 1851 2 in in IN cord-015306-us58wwmp 1851 3 podocyte podocyte NNP cord-015306-us58wwmp 1851 4 genes gene NNS cord-015306-us58wwmp 1851 5 ( ( -LRB- cord-015306-us58wwmp 1851 6 NPHS1 NPHS1 NNP cord-015306-us58wwmp 1851 7 , , , cord-015306-us58wwmp 1851 8 NPHS2 NPHS2 NNP cord-015306-us58wwmp 1851 9 , , , cord-015306-us58wwmp 1851 10 WT1 WT1 NNP cord-015306-us58wwmp 1851 11 , , , cord-015306-us58wwmp 1851 12 and and CC cord-015306-us58wwmp 1851 13 LAMB2 LAMB2 NNP cord-015306-us58wwmp 1851 14 ) ) -RRB- cord-015306-us58wwmp 1851 15 are be VBP cord-015306-us58wwmp 1851 16 associated associate VBN cord-015306-us58wwmp 1851 17 with with IN cord-015306-us58wwmp 1851 18 congenital congenital JJ cord-015306-us58wwmp 1851 19 ( ( -LRB- cord-015306-us58wwmp 1851 20 <3 <3 NNP cord-015306-us58wwmp 1851 21 months month NNS cord-015306-us58wwmp 1851 22 ) ) -RRB- cord-015306-us58wwmp 1851 23 and and CC cord-015306-us58wwmp 1851 24 infantile infantile JJ cord-015306-us58wwmp 1851 25 ( ( -LRB- cord-015306-us58wwmp 1851 26 3 3 CD cord-015306-us58wwmp 1851 27 - - SYM cord-015306-us58wwmp 1851 28 12 12 CD cord-015306-us58wwmp 1851 29 months month NNS cord-015306-us58wwmp 1851 30 ) ) -RRB- cord-015306-us58wwmp 1851 31 nephrotic nephrotic JJ cord-015306-us58wwmp 1851 32 syndrome syndrome NN cord-015306-us58wwmp 1851 33 ( ( -LRB- cord-015306-us58wwmp 1851 34 NS NS NNP cord-015306-us58wwmp 1851 35 ) ) -RRB- cord-015306-us58wwmp 1851 36 . . . cord-015306-us58wwmp 1852 1 The the DT cord-015306-us58wwmp 1852 2 purpose purpose NN cord-015306-us58wwmp 1852 3 of of IN cord-015306-us58wwmp 1852 4 this this DT cord-015306-us58wwmp 1852 5 study study NN cord-015306-us58wwmp 1852 6 is be VBZ cord-015306-us58wwmp 1852 7 to to TO cord-015306-us58wwmp 1852 8 investigate investigate VB cord-015306-us58wwmp 1852 9 the the DT cord-015306-us58wwmp 1852 10 frequency frequency NN cord-015306-us58wwmp 1852 11 of of IN cord-015306-us58wwmp 1852 12 causative causative JJ cord-015306-us58wwmp 1852 13 mutations mutation NNS cord-015306-us58wwmp 1852 14 in in IN cord-015306-us58wwmp 1852 15 these these DT cord-015306-us58wwmp 1852 16 genes gene NNS cord-015306-us58wwmp 1852 17 in in IN cord-015306-us58wwmp 1852 18 NS NS NNP cord-015306-us58wwmp 1852 19 manifesting manifest VBG cord-015306-us58wwmp 1852 20 in in IN cord-015306-us58wwmp 1852 21 the the DT cord-015306-us58wwmp 1852 22 first first JJ cord-015306-us58wwmp 1852 23 year year NN cord-015306-us58wwmp 1852 24 of of IN cord-015306-us58wwmp 1852 25 life life NN cord-015306-us58wwmp 1852 26 in in IN cord-015306-us58wwmp 1852 27 Japan Japan NNP cord-015306-us58wwmp 1852 28 . . . cord-015306-us58wwmp 1853 1 Methods method NNS cord-015306-us58wwmp 1853 2 : : : cord-015306-us58wwmp 1853 3 All all DT cord-015306-us58wwmp 1853 4 exons exon NNS cord-015306-us58wwmp 1853 5 and and CC cord-015306-us58wwmp 1853 6 exon exon NN cord-015306-us58wwmp 1853 7 - - HYPH cord-015306-us58wwmp 1853 8 intron intron NN cord-015306-us58wwmp 1853 9 boundaries boundary NNS cord-015306-us58wwmp 1853 10 were be VBD cord-015306-us58wwmp 1853 11 investigated investigate VBN cord-015306-us58wwmp 1853 12 in in IN cord-015306-us58wwmp 1853 13 consecutive consecutive JJ cord-015306-us58wwmp 1853 14 , , , cord-015306-us58wwmp 1853 15 unrelated unrelated JJ cord-015306-us58wwmp 1853 16 37 37 CD cord-015306-us58wwmp 1853 17 patients patient NNS cord-015306-us58wwmp 1853 18 from from IN cord-015306-us58wwmp 1853 19 regional regional JJ cord-015306-us58wwmp 1853 20 pediatric pediatric JJ cord-015306-us58wwmp 1853 21 kidney kidney NN cord-015306-us58wwmp 1853 22 disease disease NN cord-015306-us58wwmp 1853 23 centers center NNS cord-015306-us58wwmp 1853 24 , , , cord-015306-us58wwmp 1853 25 by by IN cord-015306-us58wwmp 1853 26 PCR pcr NN cord-015306-us58wwmp 1853 27 - - HYPH cord-015306-us58wwmp 1853 28 direct direct JJ cord-015306-us58wwmp 1853 29 sequencing sequencing NN cord-015306-us58wwmp 1853 30 . . . cord-015306-us58wwmp 1854 1 Results result NNS cord-015306-us58wwmp 1854 2 : : : cord-015306-us58wwmp 1855 1 We -PRON- PRP cord-015306-us58wwmp 1855 2 detected detect VBD cord-015306-us58wwmp 1855 3 disease disease NN cord-015306-us58wwmp 1855 4 - - HYPH cord-015306-us58wwmp 1855 5 causing cause VBG cord-015306-us58wwmp 1855 6 mutations mutation NNS cord-015306-us58wwmp 1855 7 in in IN cord-015306-us58wwmp 1855 8 64.9 64.9 CD cord-015306-us58wwmp 1855 9 % % NN cord-015306-us58wwmp 1855 10 ( ( -LRB- cord-015306-us58wwmp 1855 11 24 24 CD cord-015306-us58wwmp 1855 12 of of IN cord-015306-us58wwmp 1855 13 37 37 CD cord-015306-us58wwmp 1855 14 ) ) -RRB- cord-015306-us58wwmp 1855 15 patients patient NNS cord-015306-us58wwmp 1855 16 ( ( -LRB- cord-015306-us58wwmp 1855 17 75 75 CD cord-015306-us58wwmp 1855 18 % % NN cord-015306-us58wwmp 1855 19 in in IN cord-015306-us58wwmp 1855 20 congenital congenital JJ cord-015306-us58wwmp 1855 21 and and CC cord-015306-us58wwmp 1855 22 25 25 CD cord-015306-us58wwmp 1855 23 % % NN cord-015306-us58wwmp 1855 24 in in IN cord-015306-us58wwmp 1855 25 infantile infantile JJ cord-015306-us58wwmp 1855 26 ) ) -RRB- cord-015306-us58wwmp 1856 1 ( ( -LRB- cord-015306-us58wwmp 1856 2 Table table NN cord-015306-us58wwmp 1856 3 ) ) -RRB- cord-015306-us58wwmp 1856 4 . . . cord-015306-us58wwmp 1857 1 Objective objective NN cord-015306-us58wwmp 1857 2 : : : cord-015306-us58wwmp 1858 1 Hypercoagulability hypercoagulability NN cord-015306-us58wwmp 1858 2 along along IN cord-015306-us58wwmp 1858 3 with with IN cord-015306-us58wwmp 1858 4 thrombosis thrombosis NN cord-015306-us58wwmp 1858 5 are be VBP cord-015306-us58wwmp 1858 6 prevalent prevalent JJ cord-015306-us58wwmp 1858 7 complications complication NNS cord-015306-us58wwmp 1858 8 of of IN cord-015306-us58wwmp 1858 9 nephrotic nephrotic JJ cord-015306-us58wwmp 1858 10 syndrome syndrome NN cord-015306-us58wwmp 1858 11 . . . cord-015306-us58wwmp 1859 1 In in IN cord-015306-us58wwmp 1859 2 cases case NNS cord-015306-us58wwmp 1859 3 of of IN cord-015306-us58wwmp 1859 4 refractory refractory JJ cord-015306-us58wwmp 1859 5 nephrotic nephrotic JJ cord-015306-us58wwmp 1859 6 syndrome syndrome NN cord-015306-us58wwmp 1859 7 , , , cord-015306-us58wwmp 1859 8 intracardiac intracardiac NNP cord-015306-us58wwmp 1859 9 thrombus thrombus NN cord-015306-us58wwmp 1859 10 , , , cord-015306-us58wwmp 1859 11 although although IN cord-015306-us58wwmp 1859 12 rare rare JJ cord-015306-us58wwmp 1859 13 , , , cord-015306-us58wwmp 1859 14 is be VBZ cord-015306-us58wwmp 1859 15 a a DT cord-015306-us58wwmp 1859 16 serious serious JJ cord-015306-us58wwmp 1859 17 complication complication NN cord-015306-us58wwmp 1859 18 because because IN cord-015306-us58wwmp 1859 19 of of IN cord-015306-us58wwmp 1859 20 its -PRON- PRP$ cord-015306-us58wwmp 1859 21 association association NN cord-015306-us58wwmp 1859 22 with with IN cord-015306-us58wwmp 1859 23 morbidity morbidity NN cord-015306-us58wwmp 1859 24 and and CC cord-015306-us58wwmp 1859 25 high high JJ cord-015306-us58wwmp 1859 26 mortality mortality NN cord-015306-us58wwmp 1860 1 Herein herein RB cord-015306-us58wwmp 1860 2 , , , cord-015306-us58wwmp 1860 3 we -PRON- PRP cord-015306-us58wwmp 1860 4 report report VBP cord-015306-us58wwmp 1860 5 a a DT cord-015306-us58wwmp 1860 6 case case NN cord-015306-us58wwmp 1860 7 of of IN cord-015306-us58wwmp 1860 8 a a DT cord-015306-us58wwmp 1860 9 patient patient NN cord-015306-us58wwmp 1860 10 with with IN cord-015306-us58wwmp 1860 11 a a DT cord-015306-us58wwmp 1860 12 right right JJ cord-015306-us58wwmp 1860 13 atrial atrial JJ cord-015306-us58wwmp 1860 14 thrombus thrombus NN cord-015306-us58wwmp 1860 15 associated associate VBN cord-015306-us58wwmp 1860 16 with with IN cord-015306-us58wwmp 1860 17 nephrotic nephrotic JJ cord-015306-us58wwmp 1860 18 syndrome syndrome NN cord-015306-us58wwmp 1860 19 who who WP cord-015306-us58wwmp 1860 20 responded respond VBD cord-015306-us58wwmp 1860 21 well well RB cord-015306-us58wwmp 1860 22 to to IN cord-015306-us58wwmp 1860 23 corticosteroid corticosteroid NN cord-015306-us58wwmp 1860 24 therapy therapy NN cord-015306-us58wwmp 1860 25 and and CC cord-015306-us58wwmp 1860 26 attained attain VBD cord-015306-us58wwmp 1860 27 quick quick JJ cord-015306-us58wwmp 1860 28 remission remission NN cord-015306-us58wwmp 1860 29 . . . cord-015306-us58wwmp 1861 1 Case case NN cord-015306-us58wwmp 1861 2 Presentation presentation NN cord-015306-us58wwmp 1861 3 : : : cord-015306-us58wwmp 1861 4 A a DT cord-015306-us58wwmp 1861 5 12-year 12-year JJ cord-015306-us58wwmp 1861 6 - - HYPH cord-015306-us58wwmp 1861 7 old old JJ cord-015306-us58wwmp 1861 8 Japanese japanese JJ cord-015306-us58wwmp 1861 9 boy boy NN cord-015306-us58wwmp 1861 10 was be VBD cord-015306-us58wwmp 1861 11 referred refer VBN cord-015306-us58wwmp 1861 12 to to IN cord-015306-us58wwmp 1861 13 our -PRON- PRP$ cord-015306-us58wwmp 1861 14 hospital hospital NN cord-015306-us58wwmp 1861 15 for for IN cord-015306-us58wwmp 1861 16 a a DT cord-015306-us58wwmp 1861 17 right right JJ cord-015306-us58wwmp 1861 18 atrial atrial JJ cord-015306-us58wwmp 1861 19 thrombus thrombus NN cord-015306-us58wwmp 1861 20 associated associate VBN cord-015306-us58wwmp 1861 21 with with IN cord-015306-us58wwmp 1861 22 idiopathic idiopathic JJ cord-015306-us58wwmp 1861 23 nephrotic nephrotic JJ cord-015306-us58wwmp 1861 24 syndrome syndrome NN cord-015306-us58wwmp 1861 25 diagnosed diagnose VBD cord-015306-us58wwmp 1861 26 1 1 CD cord-015306-us58wwmp 1861 27 month month NN cord-015306-us58wwmp 1861 28 ago ago RB cord-015306-us58wwmp 1861 29 . . . cord-015306-us58wwmp 1862 1 The the DT cord-015306-us58wwmp 1862 2 patient patient NN cord-015306-us58wwmp 1862 3 had have VBD cord-015306-us58wwmp 1862 4 attained attain VBN cord-015306-us58wwmp 1862 5 the the DT cord-015306-us58wwmp 1862 6 partial partial JJ cord-015306-us58wwmp 1862 7 remission remission NN cord-015306-us58wwmp 1862 8 within within IN cord-015306-us58wwmp 1862 9 the the DT cord-015306-us58wwmp 1862 10 10 10 CD cord-015306-us58wwmp 1862 11 days day NNS cord-015306-us58wwmp 1862 12 of of IN cord-015306-us58wwmp 1862 13 the the DT cord-015306-us58wwmp 1862 14 corticosteroid corticosteroid NN cord-015306-us58wwmp 1862 15 therapy therapy NN cord-015306-us58wwmp 1862 16 initiation initiation NN cord-015306-us58wwmp 1862 17 . . . cord-015306-us58wwmp 1863 1 He -PRON- PRP cord-015306-us58wwmp 1863 2 was be VBD cord-015306-us58wwmp 1863 3 asymptomatic asymptomatic JJ cord-015306-us58wwmp 1863 4 otherwise otherwise RB cord-015306-us58wwmp 1863 5 at at IN cord-015306-us58wwmp 1863 6 the the DT cord-015306-us58wwmp 1863 7 time time NN cord-015306-us58wwmp 1863 8 of of IN cord-015306-us58wwmp 1863 9 admission admission NN cord-015306-us58wwmp 1863 10 . . . cord-015306-us58wwmp 1864 1 The the DT cord-015306-us58wwmp 1864 2 patient patient NN cord-015306-us58wwmp 1864 3 's 's POS cord-015306-us58wwmp 1864 4 vitals vital NNS cord-015306-us58wwmp 1864 5 were be VBD cord-015306-us58wwmp 1864 6 stable stable JJ cord-015306-us58wwmp 1864 7 and and CC cord-015306-us58wwmp 1864 8 laboratory laboratory NN cord-015306-us58wwmp 1864 9 values value NNS cord-015306-us58wwmp 1864 10 were be VBD cord-015306-us58wwmp 1864 11 almost almost RB cord-015306-us58wwmp 1864 12 within within IN cord-015306-us58wwmp 1864 13 the the DT cord-015306-us58wwmp 1864 14 normal normal JJ cord-015306-us58wwmp 1864 15 range range NN cord-015306-us58wwmp 1864 16 . . . cord-015306-us58wwmp 1865 1 An an DT cord-015306-us58wwmp 1865 2 echocardiogram echocardiogram NN cord-015306-us58wwmp 1865 3 showed show VBD cord-015306-us58wwmp 1865 4 a a DT cord-015306-us58wwmp 1865 5 large large JJ cord-015306-us58wwmp 1865 6 isolated isolate VBN cord-015306-us58wwmp 1865 7 hyperechoic hyperechoic JJ cord-015306-us58wwmp 1865 8 mass mass NN cord-015306-us58wwmp 1865 9 in in IN cord-015306-us58wwmp 1865 10 the the DT cord-015306-us58wwmp 1865 11 right right JJ cord-015306-us58wwmp 1865 12 atrium atrium NN cord-015306-us58wwmp 1865 13 , , , cord-015306-us58wwmp 1865 14 which which WDT cord-015306-us58wwmp 1865 15 originated originate VBD cord-015306-us58wwmp 1865 16 from from IN cord-015306-us58wwmp 1865 17 the the DT cord-015306-us58wwmp 1865 18 superior superior JJ cord-015306-us58wwmp 1865 19 right right JJ cord-015306-us58wwmp 1865 20 atrial atrial JJ cord-015306-us58wwmp 1865 21 wall wall NN cord-015306-us58wwmp 1865 22 . . . cord-015306-us58wwmp 1866 1 The the DT cord-015306-us58wwmp 1866 2 mass mass NN cord-015306-us58wwmp 1866 3 measured measure VBD cord-015306-us58wwmp 1866 4 31 31 CD cord-015306-us58wwmp 1866 5 × × NNP cord-015306-us58wwmp 1866 6 26 26 CD cord-015306-us58wwmp 1866 7 mm mm NNS cord-015306-us58wwmp 1866 8 in in IN cord-015306-us58wwmp 1866 9 diameter diameter NN cord-015306-us58wwmp 1866 10 and and CC cord-015306-us58wwmp 1866 11 traversed traverse VBN cord-015306-us58wwmp 1866 12 through through IN cord-015306-us58wwmp 1866 13 the the DT cord-015306-us58wwmp 1866 14 tricuspid tricuspid NN cord-015306-us58wwmp 1866 15 valve valve NN cord-015306-us58wwmp 1866 16 in in IN cord-015306-us58wwmp 1866 17 a a DT cord-015306-us58wwmp 1866 18 to to IN cord-015306-us58wwmp 1866 19 - - HYPH cord-015306-us58wwmp 1866 20 and and CC cord-015306-us58wwmp 1866 21 - - HYPH cord-015306-us58wwmp 1866 22 fro fro JJ cord-015306-us58wwmp 1866 23 motion motion NN cord-015306-us58wwmp 1866 24 . . . cord-015306-us58wwmp 1867 1 The the DT cord-015306-us58wwmp 1867 2 patient patient NN cord-015306-us58wwmp 1867 3 underwent undergo VBD cord-015306-us58wwmp 1867 4 emergency emergency NN cord-015306-us58wwmp 1867 5 surgical surgical JJ cord-015306-us58wwmp 1867 6 thrombectomy thrombectomy NN cord-015306-us58wwmp 1867 7 on on IN cord-015306-us58wwmp 1867 8 day day NN cord-015306-us58wwmp 1867 9 1 1 CD cord-015306-us58wwmp 1867 10 and and CC cord-015306-us58wwmp 1867 11 anticoagulation anticoagulation NN cord-015306-us58wwmp 1867 12 therapy therapy NN cord-015306-us58wwmp 1867 13 was be VBD cord-015306-us58wwmp 1867 14 started start VBN cord-015306-us58wwmp 1867 15 7 7 CD cord-015306-us58wwmp 1867 16 days day NNS cord-015306-us58wwmp 1867 17 after after IN cord-015306-us58wwmp 1867 18 the the DT cord-015306-us58wwmp 1867 19 operation operation NN cord-015306-us58wwmp 1867 20 . . . cord-015306-us58wwmp 1868 1 The the DT cord-015306-us58wwmp 1868 2 subsequent subsequent JJ cord-015306-us58wwmp 1868 3 hospital hospital NN cord-015306-us58wwmp 1868 4 stay stay NN cord-015306-us58wwmp 1868 5 was be VBD cord-015306-us58wwmp 1868 6 uneventful uneventful JJ cord-015306-us58wwmp 1868 7 , , , cord-015306-us58wwmp 1868 8 and and CC cord-015306-us58wwmp 1868 9 the the DT cord-015306-us58wwmp 1868 10 patient patient NN cord-015306-us58wwmp 1868 11 was be VBD cord-015306-us58wwmp 1868 12 discharged discharge VBN cord-015306-us58wwmp 1868 13 on on IN cord-015306-us58wwmp 1868 14 day day NN cord-015306-us58wwmp 1868 15 87 87 CD cord-015306-us58wwmp 1868 16 . . . cord-015306-us58wwmp 1869 1 Objective objective NN cord-015306-us58wwmp 1869 2 : : : cord-015306-us58wwmp 1870 1 Nephrotic nephrotic JJ cord-015306-us58wwmp 1870 2 syndrome syndrome NN cord-015306-us58wwmp 1870 3 features feature VBZ cord-015306-us58wwmp 1870 4 proteinuria proteinuria NN cord-015306-us58wwmp 1870 5 and and CC cord-015306-us58wwmp 1870 6 severe severe JJ cord-015306-us58wwmp 1870 7 sodium sodium NN cord-015306-us58wwmp 1870 8 retention retention NN cord-015306-us58wwmp 1870 9 which which WDT cord-015306-us58wwmp 1870 10 is be VBZ cord-015306-us58wwmp 1870 11 implicated implicate VBN cord-015306-us58wwmp 1870 12 in in IN cord-015306-us58wwmp 1870 13 ascites ascites NN cord-015306-us58wwmp 1870 14 and and CC cord-015306-us58wwmp 1870 15 edema edema NN cord-015306-us58wwmp 1870 16 formation formation NN cord-015306-us58wwmp 1870 17 . . . cord-015306-us58wwmp 1871 1 Previous previous JJ cord-015306-us58wwmp 1871 2 works work NNS cord-015306-us58wwmp 1871 3 realized realize VBD cord-015306-us58wwmp 1871 4 in in IN cord-015306-us58wwmp 1871 5 nephrotic nephrotic JJ cord-015306-us58wwmp 1871 6 rats rat NNS cord-015306-us58wwmp 1871 7 ( ( -LRB- cord-015306-us58wwmp 1871 8 PAN PAN NNP cord-015306-us58wwmp 1871 9 ) ) -RRB- cord-015306-us58wwmp 1871 10 clearly clearly RB cord-015306-us58wwmp 1871 11 highlighted highlight VBD cord-015306-us58wwmp 1871 12 that that IN cord-015306-us58wwmp 1871 13 , , , cord-015306-us58wwmp 1871 14 the the DT cord-015306-us58wwmp 1871 15 increase increase NN cord-015306-us58wwmp 1871 16 of of IN cord-015306-us58wwmp 1871 17 sodium sodium NN cord-015306-us58wwmp 1871 18 absorption absorption NN cord-015306-us58wwmp 1871 19 in in IN cord-015306-us58wwmp 1871 20 the the DT cord-015306-us58wwmp 1871 21 CCD ccd NN cord-015306-us58wwmp 1871 22 is be VBZ cord-015306-us58wwmp 1871 23 associated associate VBN cord-015306-us58wwmp 1871 24 with with IN cord-015306-us58wwmp 1871 25 an an DT cord-015306-us58wwmp 1871 26 increase increase NN cord-015306-us58wwmp 1871 27 activity activity NN cord-015306-us58wwmp 1871 28 of of IN cord-015306-us58wwmp 1871 29 the the DT cord-015306-us58wwmp 1871 30 Na Na NNP cord-015306-us58wwmp 1871 31 / / SYM cord-015306-us58wwmp 1871 32 K K NNP cord-015306-us58wwmp 1871 33 ATPase ATPase NNP cord-015306-us58wwmp 1871 34 ; ; : cord-015306-us58wwmp 1871 35 sodium sodium NN cord-015306-us58wwmp 1871 36 absorption absorption NN cord-015306-us58wwmp 1871 37 is be VBZ cord-015306-us58wwmp 1871 38 independent independent JJ cord-015306-us58wwmp 1871 39 of of IN cord-015306-us58wwmp 1871 40 aldosterone aldosterone NN cord-015306-us58wwmp 1871 41 , , , cord-015306-us58wwmp 1871 42 activation activation NN cord-015306-us58wwmp 1871 43 of of IN cord-015306-us58wwmp 1871 44 epithelial epithelial JJ cord-015306-us58wwmp 1871 45 sodium sodium NN cord-015306-us58wwmp 1871 46 channel channel NN cord-015306-us58wwmp 1871 47 ENaC ENaC NNP cord-015306-us58wwmp 1871 48 is be VBZ cord-015306-us58wwmp 1871 49 not not RB cord-015306-us58wwmp 1871 50 necessary necessary JJ cord-015306-us58wwmp 1871 51 and and CC cord-015306-us58wwmp 1871 52 sodium sodium NN cord-015306-us58wwmp 1871 53 absorption absorption NN cord-015306-us58wwmp 1871 54 is be VBZ cord-015306-us58wwmp 1871 55 inhibited inhibit VBN cord-015306-us58wwmp 1871 56 by by IN cord-015306-us58wwmp 1871 57 amiloride amiloride NNP cord-015306-us58wwmp 1871 58 . . . cord-015306-us58wwmp 1872 1 Our -PRON- PRP$ cord-015306-us58wwmp 1872 2 hypothesis hypothesis NN cord-015306-us58wwmp 1872 3 is be VBZ cord-015306-us58wwmp 1872 4 that that IN cord-015306-us58wwmp 1872 5 , , , cord-015306-us58wwmp 1872 6 in in IN cord-015306-us58wwmp 1872 7 nephrotic nephrotic JJ cord-015306-us58wwmp 1872 8 syndrome syndrome NN cord-015306-us58wwmp 1872 9 , , , cord-015306-us58wwmp 1872 10 another another DT cord-015306-us58wwmp 1872 11 apical apical JJ cord-015306-us58wwmp 1872 12 sodium sodium NN cord-015306-us58wwmp 1872 13 channel channel NN cord-015306-us58wwmp 1872 14 sensitive sensitive JJ cord-015306-us58wwmp 1872 15 to to IN cord-015306-us58wwmp 1872 16 amiloride amiloride NNP cord-015306-us58wwmp 1872 17 and and CC cord-015306-us58wwmp 1872 18 independent independent JJ cord-015306-us58wwmp 1872 19 of of IN cord-015306-us58wwmp 1872 20 SAAR SAAR NNP cord-015306-us58wwmp 1872 21 pathway pathway NN cord-015306-us58wwmp 1872 22 is be VBZ cord-015306-us58wwmp 1872 23 implicated implicate VBN cord-015306-us58wwmp 1872 24 in in IN cord-015306-us58wwmp 1872 25 sodium sodium NN cord-015306-us58wwmp 1872 26 absorption absorption NN cord-015306-us58wwmp 1872 27 in in IN cord-015306-us58wwmp 1872 28 the the DT cord-015306-us58wwmp 1872 29 CCD ccd NN cord-015306-us58wwmp 1872 30 . . . cord-015306-us58wwmp 1873 1 Methods method NNS cord-015306-us58wwmp 1873 2 : : : cord-015306-us58wwmp 1874 1 Transcriptome Transcriptome NNP cord-015306-us58wwmp 1874 2 of of IN cord-015306-us58wwmp 1874 3 CCDs ccd NNS cord-015306-us58wwmp 1874 4 from from IN cord-015306-us58wwmp 1874 5 control control NN cord-015306-us58wwmp 1874 6 rats rat NNS cord-015306-us58wwmp 1874 7 ( ( -LRB- cord-015306-us58wwmp 1874 8 CT CT NNP cord-015306-us58wwmp 1874 9 ) ) -RRB- cord-015306-us58wwmp 1874 10 and and CC cord-015306-us58wwmp 1874 11 PAN PAN NNP cord-015306-us58wwmp 1874 12 treated treat VBD cord-015306-us58wwmp 1874 13 clamped clamp VBD cord-015306-us58wwmp 1874 14 rats rat NNS cord-015306-us58wwmp 1874 15 ( ( -LRB- cord-015306-us58wwmp 1874 16 ADX ADX NNP cord-015306-us58wwmp 1874 17 PAN PAN NNP cord-015306-us58wwmp 1874 18 ) ) -RRB- cord-015306-us58wwmp 1874 19 was be VBD cord-015306-us58wwmp 1874 20 analyzed analyze VBN cord-015306-us58wwmp 1874 21 using use VBG cord-015306-us58wwmp 1874 22 a a DT cord-015306-us58wwmp 1874 23 high high JJ cord-015306-us58wwmp 1874 24 - - HYPH cord-015306-us58wwmp 1874 25 resolution resolution NN cord-015306-us58wwmp 1874 26 quantitative quantitative JJ cord-015306-us58wwmp 1874 27 and and CC cord-015306-us58wwmp 1874 28 comparative comparative JJ cord-015306-us58wwmp 1874 29 analysis analysis NN cord-015306-us58wwmp 1874 30 of of IN cord-015306-us58wwmp 1874 31 gene gene NN cord-015306-us58wwmp 1874 32 expression expression NN cord-015306-us58wwmp 1874 33 . . . cord-015306-us58wwmp 1875 1 Subsequently subsequently RB cord-015306-us58wwmp 1875 2 , , , cord-015306-us58wwmp 1875 3 transcriptional transcriptional JJ cord-015306-us58wwmp 1875 4 ( ( -LRB- cord-015306-us58wwmp 1875 5 RT RT NNP cord-015306-us58wwmp 1875 6 - - HYPH cord-015306-us58wwmp 1875 7 qPCR qPCR NNP cord-015306-us58wwmp 1875 8 ) ) -RRB- cord-015306-us58wwmp 1875 9 and and CC cord-015306-us58wwmp 1875 10 proteic proteic JJ cord-015306-us58wwmp 1875 11 expression expression NN cord-015306-us58wwmp 1875 12 ( ( -LRB- cord-015306-us58wwmp 1875 13 western western JJ cord-015306-us58wwmp 1875 14 blot blot NN cord-015306-us58wwmp 1875 15 and and CC cord-015306-us58wwmp 1875 16 immunohistochemistry immunohistochemistry NN cord-015306-us58wwmp 1875 17 ) ) -RRB- cord-015306-us58wwmp 1875 18 of of IN cord-015306-us58wwmp 1875 19 channel channel NNP cord-015306-us58wwmp 1875 20 were be VBD cord-015306-us58wwmp 1875 21 analyzed analyze VBN cord-015306-us58wwmp 1875 22 . . . cord-015306-us58wwmp 1876 1 Sodium sodium NN cord-015306-us58wwmp 1876 2 handling handling NN cord-015306-us58wwmp 1876 3 in in IN cord-015306-us58wwmp 1876 4 vivo vivo NN cord-015306-us58wwmp 1876 5 and and CC cord-015306-us58wwmp 1876 6 in in IN cord-015306-us58wwmp 1876 7 vitro vitro FW cord-015306-us58wwmp 1876 8 microperfused microperfuse VBN cord-015306-us58wwmp 1876 9 collecting collect VBG cord-015306-us58wwmp 1876 10 ducts duct NNS cord-015306-us58wwmp 1876 11 in in IN cord-015306-us58wwmp 1876 12 different different JJ cord-015306-us58wwmp 1876 13 conditions condition NNS cord-015306-us58wwmp 1876 14 ( ( -LRB- cord-015306-us58wwmp 1876 15 pH pH NNP cord-015306-us58wwmp 1876 16 6 6 CD cord-015306-us58wwmp 1876 17 and and CC cord-015306-us58wwmp 1876 18 7.4 7.4 CD cord-015306-us58wwmp 1876 19 , , , cord-015306-us58wwmp 1876 20 apical apical JJ cord-015306-us58wwmp 1876 21 zinc zinc NN cord-015306-us58wwmp 1876 22 0.3mM 0.3mm CD cord-015306-us58wwmp 1876 23 and and CC cord-015306-us58wwmp 1876 24 amiloride amiloride NNP cord-015306-us58wwmp 1876 25 0.1mM 0.1mm CD cord-015306-us58wwmp 1876 26 ) ) -RRB- cord-015306-us58wwmp 1876 27 was be VBD cord-015306-us58wwmp 1876 28 analyzed analyze VBN cord-015306-us58wwmp 1876 29 . . . cord-015306-us58wwmp 1877 1 Results result NNS cord-015306-us58wwmp 1877 2 : : : cord-015306-us58wwmp 1878 1 Metabolic metabolic JJ cord-015306-us58wwmp 1878 2 study study NN cord-015306-us58wwmp 1878 3 confirmed confirm VBD cord-015306-us58wwmp 1878 4 previous previous JJ cord-015306-us58wwmp 1878 5 results result NNS cord-015306-us58wwmp 1878 6 : : : cord-015306-us58wwmp 1878 7 Sodium sodium NN cord-015306-us58wwmp 1878 8 absorption absorption NN cord-015306-us58wwmp 1878 9 and and CC cord-015306-us58wwmp 1878 10 ascites ascite NNS cord-015306-us58wwmp 1878 11 were be VBD cord-015306-us58wwmp 1878 12 similar similar JJ cord-015306-us58wwmp 1878 13 in in IN cord-015306-us58wwmp 1878 14 PAN PAN NNP cord-015306-us58wwmp 1878 15 and and CC cord-015306-us58wwmp 1878 16 ADXPAN ADXPAN NNP cord-015306-us58wwmp 1878 17 rats rat NNS cord-015306-us58wwmp 1878 18 suggesting suggest VBG cord-015306-us58wwmp 1878 19 that that IN cord-015306-us58wwmp 1878 20 sodium sodium NN cord-015306-us58wwmp 1878 21 absorption absorption NN cord-015306-us58wwmp 1878 22 in in IN cord-015306-us58wwmp 1878 23 nephrotic nephrotic JJ cord-015306-us58wwmp 1878 24 syndrome syndrome NN cord-015306-us58wwmp 1878 25 was be VBD cord-015306-us58wwmp 1878 26 independent independent JJ cord-015306-us58wwmp 1878 27 of of IN cord-015306-us58wwmp 1878 28 SAAR SAAR NNP cord-015306-us58wwmp 1878 29 . . . cord-015306-us58wwmp 1879 1 Transcriptome Transcriptome NNP cord-015306-us58wwmp 1879 2 analyses analysis NNS cord-015306-us58wwmp 1879 3 highlighted highlight VBD cord-015306-us58wwmp 1879 4 an an DT cord-015306-us58wwmp 1879 5 increased increase VBN cord-015306-us58wwmp 1879 6 expression expression NN cord-015306-us58wwmp 1879 7 of of IN cord-015306-us58wwmp 1879 8 ACCN1 ACCN1 NNS cord-015306-us58wwmp 1880 1 mRNA mRNA NNP cord-015306-us58wwmp 1880 2 only only RB cord-015306-us58wwmp 1880 3 in in IN cord-015306-us58wwmp 1880 4 ADX ADX NNP cord-015306-us58wwmp 1880 5 PAN PAN NNP cord-015306-us58wwmp 1880 6 at at IN cord-015306-us58wwmp 1880 7 day day NN cord-015306-us58wwmp 1880 8 6 6 CD cord-015306-us58wwmp 1880 9 . . . cord-015306-us58wwmp 1881 1 RT RT NNP cord-015306-us58wwmp 1881 2 - - HYPH cord-015306-us58wwmp 1881 3 qPCR qPCR NNP cord-015306-us58wwmp 1881 4 confirmed confirm VBD cord-015306-us58wwmp 1881 5 an an DT cord-015306-us58wwmp 1881 6 increased increase VBN cord-015306-us58wwmp 1881 7 expression expression NN cord-015306-us58wwmp 1881 8 of of IN cord-015306-us58wwmp 1881 9 ACCN1 ACCN1 NNS cord-015306-us58wwmp 1881 10 only only RB cord-015306-us58wwmp 1881 11 in in IN cord-015306-us58wwmp 1881 12 the the DT cord-015306-us58wwmp 1881 13 CCD CCD NNP cord-015306-us58wwmp 1881 14 of of IN cord-015306-us58wwmp 1881 15 ADX ADX NNP cord-015306-us58wwmp 1881 16 PAN PAN NNP cord-015306-us58wwmp 1881 17 ( ( -LRB- cord-015306-us58wwmp 1881 18 about about RB cord-015306-us58wwmp 1881 19 eight eight CD cord-015306-us58wwmp 1881 20 time time NN cord-015306-us58wwmp 1881 21 compared compare VBN cord-015306-us58wwmp 1881 22 to to IN cord-015306-us58wwmp 1881 23 ADX ADX NNP cord-015306-us58wwmp 1881 24 CT CT NNP cord-015306-us58wwmp 1881 25 ) ) -RRB- cord-015306-us58wwmp 1881 26 . . . cord-015306-us58wwmp 1882 1 Subsequently subsequently RB cord-015306-us58wwmp 1882 2 , , , cord-015306-us58wwmp 1882 3 protein protein NN cord-015306-us58wwmp 1882 4 shows show VBZ cord-015306-us58wwmp 1882 5 an an DT cord-015306-us58wwmp 1882 6 increase increase NN cord-015306-us58wwmp 1882 7 expression expression NN cord-015306-us58wwmp 1882 8 of of IN cord-015306-us58wwmp 1882 9 ACCN1 ACCN1 NNS cord-015306-us58wwmp 1883 1 ( ( -LRB- cord-015306-us58wwmp 1883 2 ADX ADX NNP cord-015306-us58wwmp 1883 3 PAN PAN NNP cord-015306-us58wwmp 1883 4 0.72+/-0.12 0.72+/-0.12 CD cord-015306-us58wwmp 1883 5 vs vs IN cord-015306-us58wwmp 1883 6 ADX ADX NNP cord-015306-us58wwmp 1883 7 CT CT NNP cord-015306-us58wwmp 1883 8 0.31+/-0.03 0.31+/-0.03 CD cord-015306-us58wwmp 1883 9 , , , cord-015306-us58wwmp 1883 10 p p NN cord-015306-us58wwmp 1883 11 0.03 0.03 CD cord-015306-us58wwmp 1883 12 ) ) -RRB- cord-015306-us58wwmp 1883 13 and and CC cord-015306-us58wwmp 1883 14 immunohistochemistry immunohistochemistry NN cord-015306-us58wwmp 1883 15 on on IN cord-015306-us58wwmp 1883 16 microdissecated microdissecated NNP cord-015306-us58wwmp 1883 17 CCD CCD NNP cord-015306-us58wwmp 1883 18 highlighted highlight VBD cord-015306-us58wwmp 1883 19 a a DT cord-015306-us58wwmp 1883 20 strong strong JJ cord-015306-us58wwmp 1883 21 apical apical JJ cord-015306-us58wwmp 1883 22 expression expression NN cord-015306-us58wwmp 1883 23 of of IN cord-015306-us58wwmp 1883 24 ACCN1 ACCN1 NNS cord-015306-us58wwmp 1883 25 only only RB cord-015306-us58wwmp 1883 26 in in IN cord-015306-us58wwmp 1883 27 ADX ADX NNP cord-015306-us58wwmp 1883 28 PAN PAN NNP cord-015306-us58wwmp 1883 29 rats rat NNS cord-015306-us58wwmp 1883 30 . . . cord-015306-us58wwmp 1884 1 Schimke Schimke NNP cord-015306-us58wwmp 1884 2 immuno immuno JJ cord-015306-us58wwmp 1884 3 - - HYPH cord-015306-us58wwmp 1884 4 osseous osseous JJ cord-015306-us58wwmp 1884 5 dysplasia dysplasia NN cord-015306-us58wwmp 1884 6 ( ( -LRB- cord-015306-us58wwmp 1884 7 SIOD SIOD NNP cord-015306-us58wwmp 1884 8 ) ) -RRB- cord-015306-us58wwmp 1884 9 is be VBZ cord-015306-us58wwmp 1884 10 a a DT cord-015306-us58wwmp 1884 11 rare rare JJ cord-015306-us58wwmp 1884 12 autosomalrecessive autosomalrecessive JJ cord-015306-us58wwmp 1884 13 multisystem multisystem JJ cord-015306-us58wwmp 1884 14 disorder disorder NN cord-015306-us58wwmp 1884 15 , , , cord-015306-us58wwmp 1884 16 characterised characterise VBN cord-015306-us58wwmp 1884 17 by by IN cord-015306-us58wwmp 1884 18 : : : cord-015306-us58wwmp 1884 19 disproportionate disproportionate JJ cord-015306-us58wwmp 1884 20 growth growth NN cord-015306-us58wwmp 1884 21 deficiency deficiency NN cord-015306-us58wwmp 1884 22 , , , cord-015306-us58wwmp 1884 23 defective defective JJ cord-015306-us58wwmp 1884 24 cellular cellular JJ cord-015306-us58wwmp 1884 25 immunity immunity NN cord-015306-us58wwmp 1884 26 , , , cord-015306-us58wwmp 1884 27 nephrotic nephrotic JJ cord-015306-us58wwmp 1884 28 syndrome syndrome NN cord-015306-us58wwmp 1884 29 and and CC cord-015306-us58wwmp 1884 30 progressive progressive JJ cord-015306-us58wwmp 1884 31 renal renal JJ cord-015306-us58wwmp 1884 32 disease disease NN cord-015306-us58wwmp 1884 33 . . . cord-015306-us58wwmp 1885 1 SIOD SIOD NNP cord-015306-us58wwmp 1885 2 is be VBZ cord-015306-us58wwmp 1885 3 caused cause VBN cord-015306-us58wwmp 1885 4 by by IN cord-015306-us58wwmp 1885 5 bi bi JJ cord-015306-us58wwmp 1885 6 - - JJ cord-015306-us58wwmp 1885 7 allelic allelic JJ cord-015306-us58wwmp 1885 8 mutations mutation NNS cord-015306-us58wwmp 1885 9 of of IN cord-015306-us58wwmp 1885 10 SMARCAL1 smarcal1 NN cord-015306-us58wwmp 1885 11 gene gene NN cord-015306-us58wwmp 1885 12 , , , cord-015306-us58wwmp 1885 13 which which WDT cord-015306-us58wwmp 1885 14 encodes encode VBZ cord-015306-us58wwmp 1885 15 the the DT cord-015306-us58wwmp 1885 16 HepA HepA NNP cord-015306-us58wwmp 1885 17 - - HYPH cord-015306-us58wwmp 1885 18 related relate VBN cord-015306-us58wwmp 1885 19 protein protein NN cord-015306-us58wwmp 1885 20 ( ( -LRB- cord-015306-us58wwmp 1885 21 HARP HARP NNP cord-015306-us58wwmp 1885 22 ) ) -RRB- cord-015306-us58wwmp 1885 23 , , , cord-015306-us58wwmp 1885 24 a a DT cord-015306-us58wwmp 1885 25 member member NN cord-015306-us58wwmp 1885 26 of of IN cord-015306-us58wwmp 1885 27 the the DT cord-015306-us58wwmp 1885 28 SNF2 SNF2 NNP cord-015306-us58wwmp 1885 29 family family NN cord-015306-us58wwmp 1885 30 of of IN cord-015306-us58wwmp 1885 31 ATPases atpase NNS cord-015306-us58wwmp 1885 32 , , , cord-015306-us58wwmp 1885 33 acting act VBG cord-015306-us58wwmp 1885 34 as as IN cord-015306-us58wwmp 1885 35 chromatin chromatin NN cord-015306-us58wwmp 1885 36 remodelers remodeler NNS cord-015306-us58wwmp 1885 37 within within IN cord-015306-us58wwmp 1885 38 multi multi JJ cord-015306-us58wwmp 1885 39 - - JJ cord-015306-us58wwmp 1885 40 protein protein JJ cord-015306-us58wwmp 1885 41 complexes complex NNS cord-015306-us58wwmp 1885 42 . . . cord-015306-us58wwmp 1886 1 A a DT cord-015306-us58wwmp 1886 2 5-year 5-year CD cord-015306-us58wwmp 1886 3 - - HYPH cord-015306-us58wwmp 1886 4 old old JJ cord-015306-us58wwmp 1886 5 patient patient NN cord-015306-us58wwmp 1886 6 was be VBD cord-015306-us58wwmp 1886 7 hospitalized hospitalize VBN cord-015306-us58wwmp 1886 8 in in IN cord-015306-us58wwmp 1886 9 November November NNP cord-015306-us58wwmp 1886 10 2011 2011 CD cord-015306-us58wwmp 1886 11 , , , cord-015306-us58wwmp 1886 12 after after IN cord-015306-us58wwmp 1886 13 detection detection NN cord-015306-us58wwmp 1886 14 of of IN cord-015306-us58wwmp 1886 15 proteinuria proteinuria NN cord-015306-us58wwmp 1886 16 ( ( -LRB- cord-015306-us58wwmp 1886 17 1.5 1.5 CD cord-015306-us58wwmp 1886 18 g g NN cord-015306-us58wwmp 1886 19 / / SYM cord-015306-us58wwmp 1886 20 day day NN cord-015306-us58wwmp 1886 21 ) ) -RRB- cord-015306-us58wwmp 1886 22 . . . cord-015306-us58wwmp 1887 1 At at IN cord-015306-us58wwmp 1887 2 our -PRON- PRP$ cord-015306-us58wwmp 1887 3 first first JJ cord-015306-us58wwmp 1887 4 clinical clinical JJ cord-015306-us58wwmp 1887 5 examination examination NN cord-015306-us58wwmp 1887 6 : : : cord-015306-us58wwmp 1887 7 height height NN cord-015306-us58wwmp 1887 8 - - HYPH cord-015306-us58wwmp 1887 9 weightgrowth weightgrowth NN cord-015306-us58wwmp 1887 10 retardation retardation NN cord-015306-us58wwmp 1887 11 , , , cord-015306-us58wwmp 1887 12 thinning thin VBG cord-015306-us58wwmp 1887 13 hair hair NN cord-015306-us58wwmp 1887 14 , , , cord-015306-us58wwmp 1887 15 thin thin JJ cord-015306-us58wwmp 1887 16 and and CC cord-015306-us58wwmp 1887 17 hypopigmented hypopigmented JJ cord-015306-us58wwmp 1887 18 skin skin NN cord-015306-us58wwmp 1887 19 , , , cord-015306-us58wwmp 1887 20 arched arched JJ cord-015306-us58wwmp 1887 21 palate palate NN cord-015306-us58wwmp 1887 22 and and CC cord-015306-us58wwmp 1887 23 normal normal JJ cord-015306-us58wwmp 1887 24 neuro neuro JJ cord-015306-us58wwmp 1887 25 - - HYPH cord-015306-us58wwmp 1887 26 psychological psychological JJ cord-015306-us58wwmp 1887 27 development development NN cord-015306-us58wwmp 1887 28 . . . cord-015306-us58wwmp 1888 1 Serological serological JJ cord-015306-us58wwmp 1888 2 examination examination NN cord-015306-us58wwmp 1888 3 showed show VBD cord-015306-us58wwmp 1888 4 proteinuria proteinuria NN cord-015306-us58wwmp 1888 5 ( ( -LRB- cord-015306-us58wwmp 1888 6 1.7 1.7 CD cord-015306-us58wwmp 1888 7 g g NN cord-015306-us58wwmp 1888 8 / / SYM cord-015306-us58wwmp 1888 9 day day NN cord-015306-us58wwmp 1888 10 ) ) -RRB- cord-015306-us58wwmp 1888 11 , , , cord-015306-us58wwmp 1888 12 hyperchol hyperchol NNP cord-015306-us58wwmp 1888 13 . . . cord-015306-us58wwmp 1889 1 ( ( -LRB- cord-015306-us58wwmp 1889 2 Col Col NNP cord-015306-us58wwmp 1889 3 tot tot NNP cord-015306-us58wwmp 1889 4 242 242 CD cord-015306-us58wwmp 1889 5 mg mg NNP cord-015306-us58wwmp 1889 6 / / SYM cord-015306-us58wwmp 1889 7 dl dl NNP cord-015306-us58wwmp 1889 8 , , , cord-015306-us58wwmp 1889 9 LDL LDL NNP cord-015306-us58wwmp 1889 10 - - HYPH cord-015306-us58wwmp 1889 11 Col Col NNP cord-015306-us58wwmp 1889 12 165 165 CD cord-015306-us58wwmp 1889 13 mg mg NNP cord-015306-us58wwmp 1889 14 / / SYM cord-015306-us58wwmp 1889 15 dl dl NNP cord-015306-us58wwmp 1889 16 ) ) -RRB- cord-015306-us58wwmp 1889 17 and and CC cord-015306-us58wwmp 1889 18 lymphocyte lymphocyte NN cord-015306-us58wwmp 1889 19 deficiency deficiency NN cord-015306-us58wwmp 1890 1 ( ( -LRB- cord-015306-us58wwmp 1890 2 17.6%).Renal 17.6%).renal CD cord-015306-us58wwmp 1890 3 function function NN cord-015306-us58wwmp 1890 4 and and CC cord-015306-us58wwmp 1890 5 complement complement NN cord-015306-us58wwmp 1890 6 levels level NNS cord-015306-us58wwmp 1890 7 were be VBD cord-015306-us58wwmp 1890 8 normal normal JJ cord-015306-us58wwmp 1890 9 . . . cord-015306-us58wwmp 1891 1 Lymphocyte lymphocyte NN cord-015306-us58wwmp 1891 2 subpopulations subpopulation NNS cord-015306-us58wwmp 1891 3 showed show VBD cord-015306-us58wwmp 1891 4 a a DT cord-015306-us58wwmp 1891 5 decrease decrease NN cord-015306-us58wwmp 1891 6 of of IN cord-015306-us58wwmp 1891 7 T t NN cord-015306-us58wwmp 1891 8 lymphocytes lymphocyte NNS cord-015306-us58wwmp 1891 9 and and CC cord-015306-us58wwmp 1891 10 an an DT cord-015306-us58wwmp 1891 11 increase increase NN cord-015306-us58wwmp 1891 12 of of IN cord-015306-us58wwmp 1891 13 NK NK NNP cord-015306-us58wwmp 1891 14 cells(CD16 cells(CD16 NNP cord-015306-us58wwmp 1891 15 + + CC cord-015306-us58wwmp 1891 16 CD56 CD56 NNP cord-015306-us58wwmp 1891 17 + + CD cord-015306-us58wwmp 1891 18 ) ) -RRB- cord-015306-us58wwmp 1892 1 .The .The . cord-015306-us58wwmp 1893 1 patient patient NNP cord-015306-us58wwmp 1893 2 had have VBD cord-015306-us58wwmp 1893 3 also also RB cord-015306-us58wwmp 1893 4 a a DT cord-015306-us58wwmp 1893 5 detour detour NN cord-015306-us58wwmp 1893 6 back back NN cord-015306-us58wwmp 1893 7 - - HYPH cord-015306-us58wwmp 1893 8 lumbar lumbar NN cord-015306-us58wwmp 1893 9 scoliosis scoliosis NN cord-015306-us58wwmp 1893 10 and and CC cord-015306-us58wwmp 1893 11 normal normal JJ cord-015306-us58wwmp 1893 12 kidneys kidney NNS cord-015306-us58wwmp 1893 13 in in IN cord-015306-us58wwmp 1893 14 size size NN cord-015306-us58wwmp 1893 15 , , , cord-015306-us58wwmp 1893 16 but but CC cord-015306-us58wwmp 1893 17 with with IN cord-015306-us58wwmp 1893 18 reduced reduce VBN cord-015306-us58wwmp 1893 19 corticomedullarydifferentiation corticomedullarydifferentiation NN cord-015306-us58wwmp 1893 20 . . . cord-015306-us58wwmp 1894 1 We -PRON- PRP cord-015306-us58wwmp 1894 2 started start VBD cord-015306-us58wwmp 1894 3 therapy therapy NN cord-015306-us58wwmp 1894 4 with with IN cord-015306-us58wwmp 1894 5 ramipril ramipril NNP cord-015306-us58wwmp 1894 6 2.5 2.5 CD cord-015306-us58wwmp 1894 7 mg mg NNP cord-015306-us58wwmp 1894 8 / / SYM cord-015306-us58wwmp 1894 9 day day NN cord-015306-us58wwmp 1894 10 . . . cord-015306-us58wwmp 1895 1 The the DT cord-015306-us58wwmp 1895 2 24 24 CD cord-015306-us58wwmp 1895 3 hrs hrs NN cord-015306-us58wwmp 1895 4 urine urine NN cord-015306-us58wwmp 1895 5 exams exam NNS cord-015306-us58wwmp 1895 6 performed perform VBD cord-015306-us58wwmp 1895 7 monthly monthly RB cord-015306-us58wwmp 1895 8 showed show VBD cord-015306-us58wwmp 1895 9 persistent persistent JJ cord-015306-us58wwmp 1895 10 proteinuria proteinuria NN cord-015306-us58wwmp 1895 11 ( ( -LRB- cord-015306-us58wwmp 1895 12 500 500 CD cord-015306-us58wwmp 1895 13 - - SYM cord-015306-us58wwmp 1895 14 800 800 CD cord-015306-us58wwmp 1895 15 mg mg NNP cord-015306-us58wwmp 1895 16 / / SYM cord-015306-us58wwmp 1895 17 day day NN cord-015306-us58wwmp 1895 18 ) ) -RRB- cord-015306-us58wwmp 1895 19 . . . cord-015306-us58wwmp 1896 1 At at IN cord-015306-us58wwmp 1896 2 the the DT cord-015306-us58wwmp 1896 3 end end NN cord-015306-us58wwmp 1896 4 of of IN cord-015306-us58wwmp 1896 5 April April NNP cord-015306-us58wwmp 1896 6 2012 2012 CD cord-015306-us58wwmp 1896 7 , , , cord-015306-us58wwmp 1896 8 for for IN cord-015306-us58wwmp 1896 9 the the DT cord-015306-us58wwmp 1896 10 persistence persistence NN cord-015306-us58wwmp 1896 11 of of IN cord-015306-us58wwmp 1896 12 proteinuria proteinuria NN cord-015306-us58wwmp 1896 13 , , , cord-015306-us58wwmp 1896 14 we -PRON- PRP cord-015306-us58wwmp 1896 15 performed perform VBD cord-015306-us58wwmp 1896 16 renal renal JJ cord-015306-us58wwmp 1896 17 biopsy biopsy NN cord-015306-us58wwmp 1896 18 , , , cord-015306-us58wwmp 1896 19 which which WDT cord-015306-us58wwmp 1896 20 showed show VBD cord-015306-us58wwmp 1896 21 focal focal JJ cord-015306-us58wwmp 1896 22 and and CC cord-015306-us58wwmp 1896 23 segmental segmental JJ cord-015306-us58wwmp 1896 24 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 1896 25 . . . cord-015306-us58wwmp 1897 1 At at IN cord-015306-us58wwmp 1897 2 discharge discharge NN cord-015306-us58wwmp 1897 3 , , , cord-015306-us58wwmp 1897 4 she -PRON- PRP cord-015306-us58wwmp 1897 5 started start VBD cord-015306-us58wwmp 1897 6 therapy therapy NN cord-015306-us58wwmp 1897 7 with with IN cord-015306-us58wwmp 1897 8 Irbesartan Irbesartan NNP cord-015306-us58wwmp 1897 9 75 75 CD cord-015306-us58wwmp 1897 10 mg mg NNP cord-015306-us58wwmp 1897 11 / / SYM cord-015306-us58wwmp 1897 12 day day NN cord-015306-us58wwmp 1897 13 with with IN cord-015306-us58wwmp 1897 14 significant significant JJ cord-015306-us58wwmp 1897 15 reduction reduction NN cord-015306-us58wwmp 1897 16 of of IN cord-015306-us58wwmp 1897 17 proteinuria proteinuria NN cord-015306-us58wwmp 1897 18 ( ( -LRB- cord-015306-us58wwmp 1897 19 140 140 CD cord-015306-us58wwmp 1897 20 mg mg NNP cord-015306-us58wwmp 1897 21 / / SYM cord-015306-us58wwmp 1897 22 day day NN cord-015306-us58wwmp 1897 23 ) ) -RRB- cord-015306-us58wwmp 1897 24 . . . cord-015306-us58wwmp 1898 1 After after IN cord-015306-us58wwmp 1898 2 6 6 CD cord-015306-us58wwmp 1898 3 months month NNS cord-015306-us58wwmp 1898 4 of of IN cord-015306-us58wwmp 1898 5 therapy therapy NN cord-015306-us58wwmp 1898 6 , , , cord-015306-us58wwmp 1898 7 thepatient thepatient NNP cord-015306-us58wwmp 1898 8 did do VBD cord-015306-us58wwmp 1898 9 not not RB cord-015306-us58wwmp 1898 10 present present VB cord-015306-us58wwmp 1898 11 proteinuria proteinuria NN cord-015306-us58wwmp 1898 12 and and CC cord-015306-us58wwmp 1898 13 her -PRON- PRP$ cord-015306-us58wwmp 1898 14 renal renal JJ cord-015306-us58wwmp 1898 15 function function NN cord-015306-us58wwmp 1898 16 was be VBD cord-015306-us58wwmp 1898 17 normal normal JJ cord-015306-us58wwmp 1898 18 . . . cord-015306-us58wwmp 1899 1 The the DT cord-015306-us58wwmp 1899 2 molecular molecular JJ cord-015306-us58wwmp 1899 3 genetic genetic JJ cord-015306-us58wwmp 1899 4 study study NN cord-015306-us58wwmp 1899 5 of of IN cord-015306-us58wwmp 1899 6 SMARCAL1 SMARCAL1 NNP cord-015306-us58wwmp 1899 7 gene gene NN cord-015306-us58wwmp 1899 8 revealed reveal VBD cord-015306-us58wwmp 1899 9 that that DT cord-015306-us58wwmp 1899 10 patient patient NN cord-015306-us58wwmp 1899 11 was be VBD cord-015306-us58wwmp 1899 12 compound compound JJ cord-015306-us58wwmp 1899 13 heterozygous heterozygous JJ cord-015306-us58wwmp 1899 14 for for IN cord-015306-us58wwmp 1899 15 two two CD cord-015306-us58wwmp 1899 16 mutations mutation NNS cord-015306-us58wwmp 1899 17 : : : cord-015306-us58wwmp 1899 18 a a DT cord-015306-us58wwmp 1899 19 novel novel JJ cord-015306-us58wwmp 1899 20 missense missense NN cord-015306-us58wwmp 1899 21 mutation mutation NN cord-015306-us58wwmp 1899 22 in in IN cord-015306-us58wwmp 1899 23 exon exon NN cord-015306-us58wwmp 1899 24 3 3 CD cord-015306-us58wwmp 1899 25 , , , cord-015306-us58wwmp 1899 26 inherited inherit VBN cord-015306-us58wwmp 1899 27 by by IN cord-015306-us58wwmp 1899 28 mother mother NN cord-015306-us58wwmp 1899 29 , , , cord-015306-us58wwmp 1899 30 and and CC cord-015306-us58wwmp 1899 31 a a DT cord-015306-us58wwmp 1899 32 nonsense nonsense NN cord-015306-us58wwmp 1899 33 paternally paternally RB cord-015306-us58wwmp 1899 34 - - HYPH cord-015306-us58wwmp 1899 35 derived derive VBN cord-015306-us58wwmp 1899 36 mutation mutation NN cord-015306-us58wwmp 1899 37 in in IN cord-015306-us58wwmp 1899 38 exon exon NN cord-015306-us58wwmp 1899 39 17 17 CD cord-015306-us58wwmp 1899 40 , , , cord-015306-us58wwmp 1899 41 leading lead VBG cord-015306-us58wwmp 1899 42 to to IN cord-015306-us58wwmp 1899 43 a a DT cord-015306-us58wwmp 1899 44 truncated truncated JJ cord-015306-us58wwmp 1899 45 SMARCAL1 smarcal1 NN cord-015306-us58wwmp 1899 46 protein protein NN cord-015306-us58wwmp 1899 47 . . . cord-015306-us58wwmp 1900 1 Our -PRON- PRP$ cord-015306-us58wwmp 1900 2 data datum NNS cord-015306-us58wwmp 1900 3 allow allow VBP cord-015306-us58wwmp 1900 4 us -PRON- PRP cord-015306-us58wwmp 1900 5 to to TO cord-015306-us58wwmp 1900 6 diagnose diagnose VB cord-015306-us58wwmp 1900 7 a a DT cord-015306-us58wwmp 1900 8 Schimke Schimke NNP cord-015306-us58wwmp 1900 9 immuno immuno JJ cord-015306-us58wwmp 1900 10 - - HYPH cord-015306-us58wwmp 1900 11 osseous osseous JJ cord-015306-us58wwmp 1900 12 dysplasia dysplasia NN cord-015306-us58wwmp 1900 13 ( ( -LRB- cord-015306-us58wwmp 1900 14 SIOD SIOD NNP cord-015306-us58wwmp 1900 15 ) ) -RRB- cord-015306-us58wwmp 1900 16 . . . cord-015306-us58wwmp 1901 1 In in IN cord-015306-us58wwmp 1901 2 most most JJS cord-015306-us58wwmp 1901 3 patients patient NNS cord-015306-us58wwmp 1901 4 , , , cord-015306-us58wwmp 1901 5 life life NN cord-015306-us58wwmp 1901 6 expectancy expectancy NN cord-015306-us58wwmp 1901 7 is be VBZ cord-015306-us58wwmp 1901 8 limited limit VBN cord-015306-us58wwmp 1901 9 to to IN cord-015306-us58wwmp 1901 10 childhood childhood NN cord-015306-us58wwmp 1901 11 or or CC cord-015306-us58wwmp 1901 12 early early JJ cord-015306-us58wwmp 1901 13 adolescence adolescence NN cord-015306-us58wwmp 1901 14 , , , cord-015306-us58wwmp 1901 15 due due IN cord-015306-us58wwmp 1901 16 to to IN cord-015306-us58wwmp 1901 17 the the DT cord-015306-us58wwmp 1901 18 onset onset NN cord-015306-us58wwmp 1901 19 of of IN cord-015306-us58wwmp 1901 20 stroke stroke NN cord-015306-us58wwmp 1901 21 , , , cord-015306-us58wwmp 1901 22 infections infection NNS cord-015306-us58wwmp 1901 23 , , , cord-015306-us58wwmp 1901 24 hematopoietic hematopoietic JJ cord-015306-us58wwmp 1901 25 bone bone NN cord-015306-us58wwmp 1901 26 marrow marrow NN cord-015306-us58wwmp 1901 27 failure failure NN cord-015306-us58wwmp 1901 28 and and CC cord-015306-us58wwmp 1901 29 renal renal JJ cord-015306-us58wwmp 1901 30 failure failure NN cord-015306-us58wwmp 1901 31 . . . cord-015306-us58wwmp 1902 1 Only only RB cord-015306-us58wwmp 1902 2 patients patient NNS cord-015306-us58wwmp 1902 3 with with IN cord-015306-us58wwmp 1902 4 milder mild JJR cord-015306-us58wwmp 1902 5 and and CC cord-015306-us58wwmp 1902 6 late late JJ cord-015306-us58wwmp 1902 7 onset onset NN cord-015306-us58wwmp 1902 8 forms form NNS cord-015306-us58wwmp 1902 9 can can MD cord-015306-us58wwmp 1902 10 survive survive VB cord-015306-us58wwmp 1902 11 until until IN cord-015306-us58wwmp 1902 12 adulthood adulthood NN cord-015306-us58wwmp 1902 13 . . . cord-015306-us58wwmp 1903 1 Gain gain NN cord-015306-us58wwmp 1903 2 of of IN cord-015306-us58wwmp 1903 3 glycosylation glycosylation NN cord-015306-us58wwmp 1903 4 in in IN cord-015306-us58wwmp 1903 5 integrin integrin NN cord-015306-us58wwmp 1903 6 - - : cord-015306-us58wwmp 1903 7 alpha-3 alpha-3 NNP cord-015306-us58wwmp 1903 8 causes cause VBZ cord-015306-us58wwmp 1903 9 nephrotic nephrotic JJ cord-015306-us58wwmp 1903 10 syndrome syndrome NN cord-015306-us58wwmp 1903 11 and and CC cord-015306-us58wwmp 1903 12 lung lung NN cord-015306-us58wwmp 1903 13 disease disease NN cord-015306-us58wwmp 1903 14 Objective Objective NNP cord-015306-us58wwmp 1903 15 : : : cord-015306-us58wwmp 1904 1 Congenital congenital JJ cord-015306-us58wwmp 1904 2 nephrotic nephrotic JJ cord-015306-us58wwmp 1904 3 syndrome syndrome NN cord-015306-us58wwmp 1904 4 and and CC cord-015306-us58wwmp 1904 5 interstitial interstitial JJ cord-015306-us58wwmp 1904 6 lung lung NN cord-015306-us58wwmp 1904 7 disease disease NN cord-015306-us58wwmp 1904 8 is be VBZ cord-015306-us58wwmp 1904 9 a a DT cord-015306-us58wwmp 1904 10 rare rare JJ cord-015306-us58wwmp 1904 11 multiorgan multiorgan NN cord-015306-us58wwmp 1904 12 disorder disorder NN cord-015306-us58wwmp 1904 13 , , , cord-015306-us58wwmp 1904 14 characterized characterize VBN cord-015306-us58wwmp 1904 15 by by IN cord-015306-us58wwmp 1904 16 disrupted disrupt VBN cord-015306-us58wwmp 1904 17 basement basement NN cord-015306-us58wwmp 1904 18 membrane membrane NN cord-015306-us58wwmp 1904 19 structures structure NNS cord-015306-us58wwmp 1904 20 . . . cord-015306-us58wwmp 1905 1 ITGA3 ITGA3 '' cord-015306-us58wwmp 1906 1 gene gene NN cord-015306-us58wwmp 1906 2 mutations mutation NNS cord-015306-us58wwmp 1906 3 were be VBD cord-015306-us58wwmp 1906 4 recently recently RB cord-015306-us58wwmp 1906 5 identified identify VBN cord-015306-us58wwmp 1906 6 as as IN cord-015306-us58wwmp 1906 7 the the DT cord-015306-us58wwmp 1906 8 genetic genetic JJ cord-015306-us58wwmp 1906 9 cause cause NN cord-015306-us58wwmp 1906 10 of of IN cord-015306-us58wwmp 1906 11 this this DT cord-015306-us58wwmp 1906 12 disorder disorder NN cord-015306-us58wwmp 1906 13 , , , cord-015306-us58wwmp 1906 14 but but CC cord-015306-us58wwmp 1906 15 the the DT cord-015306-us58wwmp 1906 16 disease disease NN cord-015306-us58wwmp 1906 17 mechanism mechanism NN cord-015306-us58wwmp 1906 18 remains remain VBZ cord-015306-us58wwmp 1906 19 poorly poorly RB cord-015306-us58wwmp 1906 20 understood understand VBN cord-015306-us58wwmp 1906 21 . . . cord-015306-us58wwmp 1907 1 Methods method NNS cord-015306-us58wwmp 1907 2 : : : cord-015306-us58wwmp 1907 3 We -PRON- PRP cord-015306-us58wwmp 1907 4 describe describe VBP cord-015306-us58wwmp 1907 5 a a DT cord-015306-us58wwmp 1907 6 patient patient NN cord-015306-us58wwmp 1907 7 who who WP cord-015306-us58wwmp 1907 8 presented present VBD cord-015306-us58wwmp 1907 9 with with IN cord-015306-us58wwmp 1907 10 neonatal neonatal JJ cord-015306-us58wwmp 1907 11 respiratory respiratory JJ cord-015306-us58wwmp 1907 12 distress distress NN cord-015306-us58wwmp 1907 13 , , , cord-015306-us58wwmp 1907 14 glomerulosclerosis glomerulosclerosis NNP cord-015306-us58wwmp 1907 15 , , , cord-015306-us58wwmp 1907 16 proteinuria proteinuria NN cord-015306-us58wwmp 1907 17 , , , cord-015306-us58wwmp 1907 18 pulmonary pulmonary JJ cord-015306-us58wwmp 1907 19 hypoplasia hypoplasia NN cord-015306-us58wwmp 1907 20 and and CC cord-015306-us58wwmp 1907 21 alveolar alveolar NNP cord-015306-us58wwmp 1907 22 glycogenosis glycogenosis NN cord-015306-us58wwmp 1907 23 , , , cord-015306-us58wwmp 1907 24 who who WP cord-015306-us58wwmp 1907 25 died die VBD cord-015306-us58wwmp 1907 26 7 7 CD cord-015306-us58wwmp 1907 27 months month NNS cord-015306-us58wwmp 1907 28 after after IN cord-015306-us58wwmp 1907 29 birth birth NN cord-015306-us58wwmp 1907 30 due due IN cord-015306-us58wwmp 1907 31 to to IN cord-015306-us58wwmp 1907 32 respiratory respiratory JJ cord-015306-us58wwmp 1907 33 insufficiency insufficiency NN cord-015306-us58wwmp 1907 34 . . . cord-015306-us58wwmp 1908 1 A a DT cord-015306-us58wwmp 1908 2 genome genome NN cord-015306-us58wwmp 1908 3 - - HYPH cord-015306-us58wwmp 1908 4 wide wide JJ cord-015306-us58wwmp 1908 5 screening screening NN cord-015306-us58wwmp 1908 6 for for IN cord-015306-us58wwmp 1908 7 deletions deletion NNS cord-015306-us58wwmp 1908 8 and and CC cord-015306-us58wwmp 1908 9 duplications duplication NNS cord-015306-us58wwmp 1908 10 revealed reveal VBD cord-015306-us58wwmp 1908 11 a a DT cord-015306-us58wwmp 1908 12 large large JJ cord-015306-us58wwmp 1908 13 homozygous homozygous JJ cord-015306-us58wwmp 1908 14 region region NN cord-015306-us58wwmp 1908 15 that that WDT cord-015306-us58wwmp 1908 16 included include VBD cord-015306-us58wwmp 1908 17 the the DT cord-015306-us58wwmp 1908 18 ITGA3 itga3 NN cord-015306-us58wwmp 1908 19 gene gene NN cord-015306-us58wwmp 1908 20 . . . cord-015306-us58wwmp 1909 1 We -PRON- PRP cord-015306-us58wwmp 1909 2 sequenced sequence VBD cord-015306-us58wwmp 1909 3 the the DT cord-015306-us58wwmp 1909 4 gene gene NN cord-015306-us58wwmp 1909 5 and and CC cord-015306-us58wwmp 1909 6 then then RB cord-015306-us58wwmp 1909 7 conductedin conductedin NNP cord-015306-us58wwmp 1909 8 vitro vitro FW cord-015306-us58wwmp 1909 9 characterization characterization NN cord-015306-us58wwmp 1909 10 studies study NNS cord-015306-us58wwmp 1909 11 to to TO cord-015306-us58wwmp 1909 12 investigate investigate VB cord-015306-us58wwmp 1909 13 the the DT cord-015306-us58wwmp 1909 14 effect effect NN cord-015306-us58wwmp 1909 15 of of IN cord-015306-us58wwmp 1909 16 the the DT cord-015306-us58wwmp 1909 17 variant variant NN cord-015306-us58wwmp 1909 18 on on IN cord-015306-us58wwmp 1909 19 the the DT cord-015306-us58wwmp 1909 20 protein protein NN cord-015306-us58wwmp 1909 21 function function NN cord-015306-us58wwmp 1909 22 . . . cord-015306-us58wwmp 1910 1 Results result NNS cord-015306-us58wwmp 1910 2 : : : cord-015306-us58wwmp 1911 1 A a DT cord-015306-us58wwmp 1911 2 novel novel JJ cord-015306-us58wwmp 1911 3 homozygous homozygous JJ cord-015306-us58wwmp 1911 4 missense missense NN cord-015306-us58wwmp 1911 5 mutation mutation NN cord-015306-us58wwmp 1911 6 was be VBD cord-015306-us58wwmp 1911 7 identified identify VBN cord-015306-us58wwmp 1911 8 in in IN cord-015306-us58wwmp 1911 9 the the DT cord-015306-us58wwmp 1911 10 coding code VBG cord-015306-us58wwmp 1911 11 region region NN cord-015306-us58wwmp 1911 12 of of IN cord-015306-us58wwmp 1911 13 the the DT cord-015306-us58wwmp 1911 14 ITGA3 ITGA3 NNP cord-015306-us58wwmp 1911 15 gene gene NN cord-015306-us58wwmp 1911 16 , , , cord-015306-us58wwmp 1911 17 which which WDT cord-015306-us58wwmp 1911 18 introduces introduce VBZ cord-015306-us58wwmp 1911 19 an an DT cord-015306-us58wwmp 1911 20 N n CD cord-015306-us58wwmp 1911 21 - - HYPH cord-015306-us58wwmp 1911 22 glycosylation glycosylation NN cord-015306-us58wwmp 1911 23 motif motif NN cord-015306-us58wwmp 1911 24 to to IN cord-015306-us58wwmp 1911 25 the the DT cord-015306-us58wwmp 1911 26 protein protein NN cord-015306-us58wwmp 1911 27 sequence sequence NN cord-015306-us58wwmp 1911 28 . . . cord-015306-us58wwmp 1912 1 Thereby thereby RB cord-015306-us58wwmp 1912 2 , , , cord-015306-us58wwmp 1912 3 the the DT cord-015306-us58wwmp 1912 4 mutant mutant NN cord-015306-us58wwmp 1912 5 integrin integrin VBD cord-015306-us58wwmp 1912 6 alpha-3 alpha-3 NNP cord-015306-us58wwmp 1912 7 protein protein NN cord-015306-us58wwmp 1912 8 becomes become VBZ cord-015306-us58wwmp 1912 9 hyperglycosylated hyperglycosylate VBN cord-015306-us58wwmp 1912 10 . . . cord-015306-us58wwmp 1913 1 Functional functional JJ cord-015306-us58wwmp 1913 2 studies study NNS cord-015306-us58wwmp 1913 3 demonstrated demonstrate VBD cord-015306-us58wwmp 1913 4 that that IN cord-015306-us58wwmp 1913 5 the the DT cord-015306-us58wwmp 1913 6 conformation conformation NN cord-015306-us58wwmp 1913 7 of of IN cord-015306-us58wwmp 1913 8 integrin integrin NN cord-015306-us58wwmp 1913 9 alpha-3 alpha-3 NNP cord-015306-us58wwmp 1913 10 is be VBZ cord-015306-us58wwmp 1913 11 affected affect VBN cord-015306-us58wwmp 1913 12 and and CC cord-015306-us58wwmp 1913 13 the the DT cord-015306-us58wwmp 1913 14 mutant mutant JJ cord-015306-us58wwmp 1913 15 alpha-3 alpha-3 NNP cord-015306-us58wwmp 1913 16 precursor precursor NN cord-015306-us58wwmp 1913 17 is be VBZ cord-015306-us58wwmp 1913 18 targeted target VBN cord-015306-us58wwmp 1913 19 for for IN cord-015306-us58wwmp 1913 20 degradation degradation NN cord-015306-us58wwmp 1913 21 . . . cord-015306-us58wwmp 1914 1 Consistent consistent JJ cord-015306-us58wwmp 1914 2 with with IN cord-015306-us58wwmp 1914 3 these these DT cord-015306-us58wwmp 1914 4 findings finding NNS cord-015306-us58wwmp 1914 5 , , , cord-015306-us58wwmp 1914 6 alpha-3 alpha-3 NNP cord-015306-us58wwmp 1914 7 integrin integrin NN cord-015306-us58wwmp 1914 8 was be VBD cord-015306-us58wwmp 1914 9 not not RB cord-015306-us58wwmp 1914 10 detected detect VBN cord-015306-us58wwmp 1914 11 in in IN cord-015306-us58wwmp 1914 12 the the DT cord-015306-us58wwmp 1914 13 patient patient JJ cord-015306-us58wwmp 1914 14 glomeruli glomerulus NNS cord-015306-us58wwmp 1914 15 . . . cord-015306-us58wwmp 1915 1 Furthermore furthermore RB cord-015306-us58wwmp 1915 2 , , , cord-015306-us58wwmp 1915 3 integrin integrin VB cord-015306-us58wwmp 1915 4 alpha-3 alpha-3 NNP cord-015306-us58wwmp 1915 5 protein protein NN cord-015306-us58wwmp 1915 6 expression expression NN cord-015306-us58wwmp 1915 7 was be VBD cord-015306-us58wwmp 1915 8 absent absent JJ cord-015306-us58wwmp 1915 9 in in IN cord-015306-us58wwmp 1915 10 murine murine JJ cord-015306-us58wwmp 1915 11 podocytes podocyte NNS cord-015306-us58wwmp 1915 12 that that WDT cord-015306-us58wwmp 1915 13 lack lack VBP cord-015306-us58wwmp 1915 14 endogenous endogenous JJ cord-015306-us58wwmp 1915 15 integrin integrin NN cord-015306-us58wwmp 1915 16 alpha-3 alpha-3 NNP cord-015306-us58wwmp 1915 17 and and CC cord-015306-us58wwmp 1915 18 transfected transfecte VBN cord-015306-us58wwmp 1915 19 with with IN cord-015306-us58wwmp 1915 20 mutant mutant NN cord-015306-us58wwmp 1915 21 ITGA3 ITGA3 '' cord-015306-us58wwmp 1915 22 . . . cord-015306-us58wwmp 1916 1 Conclusion conclusion NN cord-015306-us58wwmp 1916 2 : : : cord-015306-us58wwmp 1917 1 Our -PRON- PRP$ cord-015306-us58wwmp 1917 2 findings finding NNS cord-015306-us58wwmp 1917 3 underscore underscore VBP cord-015306-us58wwmp 1917 4 the the DT cord-015306-us58wwmp 1917 5 role role NN cord-015306-us58wwmp 1917 6 of of IN cord-015306-us58wwmp 1917 7 the the DT cord-015306-us58wwmp 1917 8 integrin integrin NN cord-015306-us58wwmp 1917 9 alpha-3beta-1 alpha-3beta-1 NNP cord-015306-us58wwmp 1917 10 complex complex JJ cord-015306-us58wwmp 1917 11 as as IN cord-015306-us58wwmp 1917 12 the the DT cord-015306-us58wwmp 1917 13 main main JJ cord-015306-us58wwmp 1917 14 regulator regulator NN cord-015306-us58wwmp 1917 15 of of IN cord-015306-us58wwmp 1917 16 podocyte podocyte NNP cord-015306-us58wwmp 1917 17 basement basement NN cord-015306-us58wwmp 1917 18 membrane membrane NN cord-015306-us58wwmp 1917 19 integrity integrity NN cord-015306-us58wwmp 1917 20 . . . cord-015306-us58wwmp 1918 1 Here here RB cord-015306-us58wwmp 1918 2 , , , cord-015306-us58wwmp 1918 3 we -PRON- PRP cord-015306-us58wwmp 1918 4 show show VBP cord-015306-us58wwmp 1918 5 that that IN cord-015306-us58wwmp 1918 6 hyperglycosylation hyperglycosylation NN cord-015306-us58wwmp 1918 7 of of IN cord-015306-us58wwmp 1918 8 the the DT cord-015306-us58wwmp 1918 9 integrin integrin NN cord-015306-us58wwmp 1918 10 alpha-3 alpha-3 NNP cord-015306-us58wwmp 1918 11 subunit subunit NN cord-015306-us58wwmp 1918 12 , , , cord-015306-us58wwmp 1918 13 causing cause VBG cord-015306-us58wwmp 1918 14 the the DT cord-015306-us58wwmp 1918 15 complete complete JJ cord-015306-us58wwmp 1918 16 lack lack NN cord-015306-us58wwmp 1918 17 of of IN cord-015306-us58wwmp 1918 18 alpha-3-beta-1 alpha-3-beta-1 NNP cord-015306-us58wwmp 1918 19 expression expression NN cord-015306-us58wwmp 1918 20 on on IN cord-015306-us58wwmp 1918 21 the the DT cord-015306-us58wwmp 1918 22 basement basement NN cord-015306-us58wwmp 1918 23 membrane membrane NN cord-015306-us58wwmp 1918 24 , , , cord-015306-us58wwmp 1918 25 is be VBZ cord-015306-us58wwmp 1918 26 a a DT cord-015306-us58wwmp 1918 27 new new JJ cord-015306-us58wwmp 1918 28 pathogenic pathogenic JJ cord-015306-us58wwmp 1918 29 mechanism mechanism NN cord-015306-us58wwmp 1918 30 underlying underlie VBG cord-015306-us58wwmp 1918 31 congenital congenital JJ cord-015306-us58wwmp 1918 32 nephrotic nephrotic JJ cord-015306-us58wwmp 1918 33 syndrome syndrome NN cord-015306-us58wwmp 1918 34 and and CC cord-015306-us58wwmp 1918 35 interstitial interstitial JJ cord-015306-us58wwmp 1918 36 lung lung NN cord-015306-us58wwmp 1918 37 disease disease NN cord-015306-us58wwmp 1918 38 . . . cord-015306-us58wwmp 1919 1 ITGA3 ITGA3 '' cord-015306-us58wwmp 1920 1 mutation mutation NN cord-015306-us58wwmp 1920 2 screening screening NN cord-015306-us58wwmp 1920 3 was be VBD cord-015306-us58wwmp 1920 4 directly directly RB cord-015306-us58wwmp 1920 5 implemented implement VBN cord-015306-us58wwmp 1920 6 in in IN cord-015306-us58wwmp 1920 7 DNA dna NN cord-015306-us58wwmp 1920 8 diagnostics diagnostic NNS cord-015306-us58wwmp 1920 9 , , , cord-015306-us58wwmp 1920 10 facilitating facilitate VBG cord-015306-us58wwmp 1920 11 early early JJ cord-015306-us58wwmp 1920 12 diagnosis diagnosis NN cord-015306-us58wwmp 1920 13 , , , cord-015306-us58wwmp 1920 14 recurrence recurrence NN cord-015306-us58wwmp 1920 15 risk risk NN cord-015306-us58wwmp 1920 16 estimation estimation NN cord-015306-us58wwmp 1920 17 , , , cord-015306-us58wwmp 1920 18 and and CC cord-015306-us58wwmp 1920 19 genetic genetic JJ cord-015306-us58wwmp 1920 20 counselling counselling NN cord-015306-us58wwmp 1920 21 . . . cord-015306-us58wwmp 1921 1 The the DT cord-015306-us58wwmp 1921 2 Clinical Clinical NNP cord-015306-us58wwmp 1921 3 Study Study NNP cord-015306-us58wwmp 1921 4 on on IN cord-015306-us58wwmp 1921 5 PKHD1 PKHD1 NNS cord-015306-us58wwmp 1922 1 Gene gene NN cord-015306-us58wwmp 1922 2 - - HYPH cord-015306-us58wwmp 1922 3 based base VBN cord-015306-us58wwmp 1922 4 Testing testing NN cord-015306-us58wwmp 1922 5 for for IN cord-015306-us58wwmp 1922 6 the the DT cord-015306-us58wwmp 1922 7 diagnosis diagnosis NN cord-015306-us58wwmp 1922 8 of of IN cord-015306-us58wwmp 1922 9 ARPKD ARPKD NNP cord-015306-us58wwmp 1922 10 Objective Objective NNP cord-015306-us58wwmp 1923 1 : : : cord-015306-us58wwmp 1923 2 In in IN cord-015306-us58wwmp 1923 3 order order NN cord-015306-us58wwmp 1923 4 to to TO cord-015306-us58wwmp 1923 5 study study VB cord-015306-us58wwmp 1923 6 the the DT cord-015306-us58wwmp 1923 7 implications implication NNS cord-015306-us58wwmp 1923 8 of of IN cord-015306-us58wwmp 1923 9 PKHD1 PKHD1 NNS cord-015306-us58wwmp 1923 10 gene gene NN cord-015306-us58wwmp 1923 11 - - HYPH cord-015306-us58wwmp 1923 12 based base VBN cord-015306-us58wwmp 1923 13 testing testing NN cord-015306-us58wwmp 1923 14 for for IN cord-015306-us58wwmp 1923 15 ARPKD ARPKD NNP cord-015306-us58wwmp 1923 16 diagnosis diagnosis NN cord-015306-us58wwmp 1923 17 in in IN cord-015306-us58wwmp 1923 18 clinical clinical JJ cord-015306-us58wwmp 1923 19 practice practice NN cord-015306-us58wwmp 1923 20 , , , cord-015306-us58wwmp 1923 21 we -PRON- PRP cord-015306-us58wwmp 1923 22 performed perform VBD cord-015306-us58wwmp 1923 23 a a DT cord-015306-us58wwmp 1923 24 prospective prospective JJ cord-015306-us58wwmp 1923 25 study study NN cord-015306-us58wwmp 1923 26 to to TO cord-015306-us58wwmp 1923 27 apply apply VB cord-015306-us58wwmp 1923 28 PKHD1-based PKHD1-based NNP cord-015306-us58wwmp 1923 29 genetic genetic JJ cord-015306-us58wwmp 1923 30 testing testing NN cord-015306-us58wwmp 1923 31 to to IN cord-015306-us58wwmp 1923 32 the the DT cord-015306-us58wwmp 1923 33 suspected suspect VBN cord-015306-us58wwmp 1923 34 ARPKD ARPKD NNP cord-015306-us58wwmp 1923 35 patients patient NNS cord-015306-us58wwmp 1923 36 . . . cord-015306-us58wwmp 1924 1 Methods method NNS cord-015306-us58wwmp 1924 2 : : : cord-015306-us58wwmp 1924 3 12 12 CD cord-015306-us58wwmp 1924 4 suspected suspect VBN cord-015306-us58wwmp 1924 5 ARPKD ARPKD NNP cord-015306-us58wwmp 1924 6 patients patient NNS cord-015306-us58wwmp 1924 7 from from IN cord-015306-us58wwmp 1924 8 10 10 CD cord-015306-us58wwmp 1924 9 unrelated unrelated JJ cord-015306-us58wwmp 1924 10 families family NNS cord-015306-us58wwmp 1924 11 were be VBD cord-015306-us58wwmp 1924 12 detected detect VBN cord-015306-us58wwmp 1924 13 on on IN cord-015306-us58wwmp 1924 14 mutations mutation NNS cord-015306-us58wwmp 1924 15 of of IN cord-015306-us58wwmp 1924 16 PKHD1 PKHD1 NNS cord-015306-us58wwmp 1924 17 gene gene NN cord-015306-us58wwmp 1924 18 by by IN cord-015306-us58wwmp 1924 19 PCR PCR NNP cord-015306-us58wwmp 1924 20 direct direct JJ cord-015306-us58wwmp 1924 21 sequencing sequencing NN cord-015306-us58wwmp 1924 22 . . . cord-015306-us58wwmp 1925 1 These these DT cord-015306-us58wwmp 1925 2 patients patient NNS cord-015306-us58wwmp 1925 3 were be VBD cord-015306-us58wwmp 1925 4 evaluated evaluate VBN cord-015306-us58wwmp 1925 5 by by IN cord-015306-us58wwmp 1925 6 combining combine VBG cord-015306-us58wwmp 1925 7 the the DT cord-015306-us58wwmp 1925 8 testing testing NN cord-015306-us58wwmp 1925 9 results result NNS cord-015306-us58wwmp 1925 10 and and CC cord-015306-us58wwmp 1925 11 their -PRON- PRP$ cord-015306-us58wwmp 1925 12 clinical clinical JJ cord-015306-us58wwmp 1925 13 materials material NNS cord-015306-us58wwmp 1925 14 . . . cord-015306-us58wwmp 1926 1 Results result NNS cord-015306-us58wwmp 1926 2 : : : cord-015306-us58wwmp 1927 1 In in IN cord-015306-us58wwmp 1927 2 the the DT cord-015306-us58wwmp 1927 3 6 6 CD cord-015306-us58wwmp 1927 4 detected detect VBN cord-015306-us58wwmp 1927 5 children child NNS cord-015306-us58wwmp 1927 6 , , , cord-015306-us58wwmp 1927 7 4 4 CD cord-015306-us58wwmp 1927 8 mutations mutation NNS cord-015306-us58wwmp 1927 9 ( ( -LRB- cord-015306-us58wwmp 1927 10 P137S P137S NNP cord-015306-us58wwmp 1927 11 , , , cord-015306-us58wwmp 1927 12 V836A V836A NNP cord-015306-us58wwmp 1927 13 , , , cord-015306-us58wwmp 1927 14 Q1574H Q1574H NNP cord-015306-us58wwmp 1927 15 , , , cord-015306-us58wwmp 1927 16 L2658X L2658X NNP cord-015306-us58wwmp 1927 17 ) ) -RRB- cord-015306-us58wwmp 1927 18 were be VBD cord-015306-us58wwmp 1927 19 novel novel JJ cord-015306-us58wwmp 1927 20 and and CC cord-015306-us58wwmp 1927 21 7 7 CD cord-015306-us58wwmp 1927 22 mutations mutation NNS cord-015306-us58wwmp 1928 1 ( ( -LRB- cord-015306-us58wwmp 1928 2 T36 T36 NNP cord-015306-us58wwmp 1928 3 M M NNP cord-015306-us58wwmp 1928 4 , , , cord-015306-us58wwmp 1928 5 R559W R559W NNP cord-015306-us58wwmp 1928 6 , , , cord-015306-us58wwmp 1928 7 R760C R760C NNP cord-015306-us58wwmp 1928 8 , , , cord-015306-us58wwmp 1928 9 N830S N830S NNP cord-015306-us58wwmp 1928 10 , , , cord-015306-us58wwmp 1928 11 A1262V A1262V NNP cord-015306-us58wwmp 1928 12 , , , cord-015306-us58wwmp 1928 13 Q3899R Q3899R NNP cord-015306-us58wwmp 1928 14 , , , cord-015306-us58wwmp 1928 15 Q4048R Q4048R NNP cord-015306-us58wwmp 1928 16 ) ) -RRB- cord-015306-us58wwmp 1928 17 were be VBD cord-015306-us58wwmp 1928 18 previously previously RB cord-015306-us58wwmp 1928 19 described describe VBN cord-015306-us58wwmp 1928 20 . . . cord-015306-us58wwmp 1929 1 4 4 CD cord-015306-us58wwmp 1929 2 of of IN cord-015306-us58wwmp 1929 3 the the DT cord-015306-us58wwmp 1929 4 11 11 CD cord-015306-us58wwmp 1929 5 variants variant NNS cord-015306-us58wwmp 1929 6 were be VBD cord-015306-us58wwmp 1929 7 definite definite JJ cord-015306-us58wwmp 1929 8 pathogenic pathogenic JJ cord-015306-us58wwmp 1929 9 mutations mutation NNS cord-015306-us58wwmp 1929 10 . . . cord-015306-us58wwmp 1930 1 Two two CD cord-015306-us58wwmp 1930 2 pathogenic pathogenic JJ cord-015306-us58wwmp 1930 3 mutations mutation NNS cord-015306-us58wwmp 1930 4 in in IN cord-015306-us58wwmp 1930 5 both both DT cord-015306-us58wwmp 1930 6 chromosomes chromosome NNS cord-015306-us58wwmp 1930 7 were be VBD cord-015306-us58wwmp 1930 8 found find VBN cord-015306-us58wwmp 1930 9 in in IN cord-015306-us58wwmp 1930 10 2 2 CD cord-015306-us58wwmp 1930 11 out out IN cord-015306-us58wwmp 1930 12 of of IN cord-015306-us58wwmp 1930 13 6 6 CD cord-015306-us58wwmp 1930 14 families family NNS cord-015306-us58wwmp 1930 15 ( ( -LRB- cord-015306-us58wwmp 1930 16 30 30 CD cord-015306-us58wwmp 1930 17 % % NN cord-015306-us58wwmp 1930 18 ) ) -RRB- cord-015306-us58wwmp 1930 19 , , , cord-015306-us58wwmp 1930 20 which which WDT cord-015306-us58wwmp 1930 21 greatly greatly RB cord-015306-us58wwmp 1930 22 aid aid VBP cord-015306-us58wwmp 1930 23 to to IN cord-015306-us58wwmp 1930 24 making make VBG cord-015306-us58wwmp 1930 25 definite definite JJ cord-015306-us58wwmp 1930 26 diagnoses diagnosis NNS cord-015306-us58wwmp 1930 27 . . . cord-015306-us58wwmp 1931 1 The the DT cord-015306-us58wwmp 1931 2 4 4 CD cord-015306-us58wwmp 1931 3 families family NNS cord-015306-us58wwmp 1931 4 with with IN cord-015306-us58wwmp 1931 5 perinatal perinatal JJ cord-015306-us58wwmp 1931 6 presentation presentation NN cord-015306-us58wwmp 1931 7 consisted consist VBD cord-015306-us58wwmp 1931 8 of of IN cord-015306-us58wwmp 1931 9 2 2 CD cord-015306-us58wwmp 1931 10 fetuses fetus NNS cord-015306-us58wwmp 1931 11 and and CC cord-015306-us58wwmp 1931 12 2 2 CD cord-015306-us58wwmp 1931 13 couples couple NNS cord-015306-us58wwmp 1931 14 . . . cord-015306-us58wwmp 1932 1 One one CD cord-015306-us58wwmp 1932 2 definite definite JJ cord-015306-us58wwmp 1932 3 pathogenic pathogenic JJ cord-015306-us58wwmp 1932 4 mutation mutation NN cord-015306-us58wwmp 1932 5 ( ( -LRB- cord-015306-us58wwmp 1932 6 S3457C S3457C NNP cord-015306-us58wwmp 1932 7 ) ) -RRB- cord-015306-us58wwmp 1932 8 was be VBD cord-015306-us58wwmp 1932 9 found find VBN cord-015306-us58wwmp 1932 10 in in IN cord-015306-us58wwmp 1932 11 the the DT cord-015306-us58wwmp 1932 12 wife wife NN cord-015306-us58wwmp 1932 13 of of IN cord-015306-us58wwmp 1932 14 family family NN cord-015306-us58wwmp 1932 15 No.9 no.9 CD cord-015306-us58wwmp 1932 16 , , , cord-015306-us58wwmp 1932 17 however however RB cord-015306-us58wwmp 1932 18 , , , cord-015306-us58wwmp 1932 19 it -PRON- PRP cord-015306-us58wwmp 1932 20 was be VBD cord-015306-us58wwmp 1932 21 still still RB cord-015306-us58wwmp 1932 22 difficult difficult JJ cord-015306-us58wwmp 1932 23 in in IN cord-015306-us58wwmp 1932 24 conforming conform VBG cord-015306-us58wwmp 1932 25 the the DT cord-015306-us58wwmp 1932 26 diagnosis diagnosis NN cord-015306-us58wwmp 1932 27 owing owe VBG cord-015306-us58wwmp 1932 28 to to IN cord-015306-us58wwmp 1932 29 lack lack NN cord-015306-us58wwmp 1932 30 of of IN cord-015306-us58wwmp 1932 31 the the DT cord-015306-us58wwmp 1932 32 pathogenic pathogenic JJ cord-015306-us58wwmp 1932 33 mutation mutation NN cord-015306-us58wwmp 1932 34 from from IN cord-015306-us58wwmp 1932 35 the the DT cord-015306-us58wwmp 1932 36 husband husband NN cord-015306-us58wwmp 1932 37 . . . cord-015306-us58wwmp 1933 1 For for IN cord-015306-us58wwmp 1933 2 the the DT cord-015306-us58wwmp 1933 3 other other JJ cord-015306-us58wwmp 1933 4 families family NNS cord-015306-us58wwmp 1933 5 , , , cord-015306-us58wwmp 1933 6 only only RB cord-015306-us58wwmp 1933 7 some some DT cord-015306-us58wwmp 1933 8 potential potential JJ cord-015306-us58wwmp 1933 9 mutations mutation NNS cord-015306-us58wwmp 1933 10 were be VBD cord-015306-us58wwmp 1933 11 found find VBN cord-015306-us58wwmp 1933 12 . . . cord-015306-us58wwmp 1934 1 Two two CD cord-015306-us58wwmp 1934 2 in in IN cord-015306-us58wwmp 1934 3 four four CD cord-015306-us58wwmp 1934 4 children child NNS cord-015306-us58wwmp 1934 5 with with IN cord-015306-us58wwmp 1934 6 congenital congenital JJ cord-015306-us58wwmp 1934 7 hepatic hepatic JJ cord-015306-us58wwmp 1934 8 fibrosis fibrosis NN cord-015306-us58wwmp 1934 9 were be VBD cord-015306-us58wwmp 1934 10 detected detect VBN cord-015306-us58wwmp 1934 11 two two CD cord-015306-us58wwmp 1934 12 pathogenic pathogenic JJ cord-015306-us58wwmp 1934 13 mutations mutation NNS cord-015306-us58wwmp 1934 14 in in IN cord-015306-us58wwmp 1934 15 both both DT cord-015306-us58wwmp 1934 16 chromosomes chromosome NNS cord-015306-us58wwmp 1934 17 , , , cord-015306-us58wwmp 1934 18 and and CC cord-015306-us58wwmp 1934 19 their -PRON- PRP$ cord-015306-us58wwmp 1934 20 liver liver NN cord-015306-us58wwmp 1934 21 functions function NNS cord-015306-us58wwmp 1934 22 were be VBD cord-015306-us58wwmp 1934 23 obviously obviously RB cord-015306-us58wwmp 1934 24 lower low JJR cord-015306-us58wwmp 1934 25 than than IN cord-015306-us58wwmp 1934 26 the the DT cord-015306-us58wwmp 1934 27 other other JJ cord-015306-us58wwmp 1934 28 two two CD cord-015306-us58wwmp 1934 29 children child NNS cord-015306-us58wwmp 1934 30 without without IN cord-015306-us58wwmp 1934 31 pathogenic pathogenic JJ cord-015306-us58wwmp 1934 32 mutations mutation NNS cord-015306-us58wwmp 1934 33 . . . cord-015306-us58wwmp 1935 1 Conclusion conclusion NN cord-015306-us58wwmp 1935 2 : : : cord-015306-us58wwmp 1935 3 PKHD1 PKHD1 NNS cord-015306-us58wwmp 1936 1 gene gene NN cord-015306-us58wwmp 1936 2 - - HYPH cord-015306-us58wwmp 1936 3 based base VBN cord-015306-us58wwmp 1936 4 testing testing NN cord-015306-us58wwmp 1936 5 is be VBZ cord-015306-us58wwmp 1936 6 an an DT cord-015306-us58wwmp 1936 7 effective effective JJ cord-015306-us58wwmp 1936 8 means mean NNS cord-015306-us58wwmp 1936 9 for for IN cord-015306-us58wwmp 1936 10 the the DT cord-015306-us58wwmp 1936 11 diagnosis diagnosis NN cord-015306-us58wwmp 1936 12 of of IN cord-015306-us58wwmp 1936 13 ARPKD ARPKD NNP cord-015306-us58wwmp 1936 14 , , , cord-015306-us58wwmp 1936 15 at at IN cord-015306-us58wwmp 1936 16 the the DT cord-015306-us58wwmp 1936 17 same same JJ cord-015306-us58wwmp 1936 18 time time NN cord-015306-us58wwmp 1936 19 it -PRON- PRP cord-015306-us58wwmp 1936 20 could could MD cord-015306-us58wwmp 1936 21 improve improve VB cord-015306-us58wwmp 1936 22 the the DT cord-015306-us58wwmp 1936 23 understanding understanding NN cord-015306-us58wwmp 1936 24 of of IN cord-015306-us58wwmp 1936 25 this this DT cord-015306-us58wwmp 1936 26 disease disease NN cord-015306-us58wwmp 1936 27 by by IN cord-015306-us58wwmp 1936 28 analysing analyse VBG cord-015306-us58wwmp 1936 29 the the DT cord-015306-us58wwmp 1936 30 testing testing NN cord-015306-us58wwmp 1936 31 results result NNS cord-015306-us58wwmp 1936 32 and and CC cord-015306-us58wwmp 1936 33 their -PRON- PRP$ cord-015306-us58wwmp 1936 34 clinical clinical JJ cord-015306-us58wwmp 1936 35 materials material NNS cord-015306-us58wwmp 1936 36 . . . cord-015306-us58wwmp 1937 1 Objective objective NN cord-015306-us58wwmp 1937 2 : : : cord-015306-us58wwmp 1938 1 To to TO cord-015306-us58wwmp 1938 2 present present VB cord-015306-us58wwmp 1938 3 a a DT cord-015306-us58wwmp 1938 4 case case NN cord-015306-us58wwmp 1938 5 of of IN cord-015306-us58wwmp 1938 6 Schimke Schimke NNP cord-015306-us58wwmp 1938 7 Immuno Immuno NNP cord-015306-us58wwmp 1938 8 - - HYPH cord-015306-us58wwmp 1938 9 Osseous osseous JJ cord-015306-us58wwmp 1938 10 Dysplasia dysplasia NN cord-015306-us58wwmp 1938 11 ( ( -LRB- cord-015306-us58wwmp 1938 12 SIOD SIOD NNP cord-015306-us58wwmp 1938 13 ) ) -RRB- cord-015306-us58wwmp 1938 14 which which WDT cord-015306-us58wwmp 1938 15 is be VBZ cord-015306-us58wwmp 1938 16 the the DT cord-015306-us58wwmp 1938 17 first first JJ cord-015306-us58wwmp 1938 18 to to TO cord-015306-us58wwmp 1938 19 be be VB cord-015306-us58wwmp 1938 20 reported report VBN cord-015306-us58wwmp 1938 21 from from IN cord-015306-us58wwmp 1938 22 Egypt Egypt NNP cord-015306-us58wwmp 1938 23 . . . cord-015306-us58wwmp 1939 1 Methods method NNS cord-015306-us58wwmp 1939 2 and and CC cord-015306-us58wwmp 1939 3 Results result NNS cord-015306-us58wwmp 1940 1 : : : cord-015306-us58wwmp 1940 2 This this DT cord-015306-us58wwmp 1940 3 article article NN cord-015306-us58wwmp 1940 4 presents present VBZ cord-015306-us58wwmp 1940 5 a a DT cord-015306-us58wwmp 1940 6 case case NN cord-015306-us58wwmp 1940 7 from from IN cord-015306-us58wwmp 1940 8 Egypt Egypt NNP cord-015306-us58wwmp 1940 9 with with IN cord-015306-us58wwmp 1940 10 mild mild JJ cord-015306-us58wwmp 1940 11 form form NN cord-015306-us58wwmp 1940 12 of of IN cord-015306-us58wwmp 1940 13 SIOD SIOD NNP cord-015306-us58wwmp 1940 14 presented present VBN cord-015306-us58wwmp 1940 15 at at IN cord-015306-us58wwmp 1940 16 the the DT cord-015306-us58wwmp 1940 17 age age NN cord-015306-us58wwmp 1940 18 of of IN cord-015306-us58wwmp 1940 19 14.5 14.5 CD cord-015306-us58wwmp 1940 20 years year NNS cord-015306-us58wwmp 1940 21 with with IN cord-015306-us58wwmp 1940 22 disproportionate disproportionate JJ cord-015306-us58wwmp 1940 23 short short JJ cord-015306-us58wwmp 1940 24 stature stature NN cord-015306-us58wwmp 1940 25 , , , cord-015306-us58wwmp 1940 26 SRNS SRNS NNP cord-015306-us58wwmp 1940 27 ( ( -LRB- cord-015306-us58wwmp 1940 28 focal focal JJ cord-015306-us58wwmp 1940 29 segmental segmental JJ cord-015306-us58wwmp 1940 30 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 1940 31 ) ) -RRB- cord-015306-us58wwmp 1940 32 , , , cord-015306-us58wwmp 1940 33 laboratory laboratory NN cord-015306-us58wwmp 1940 34 evidence evidence NN cord-015306-us58wwmp 1940 35 of of IN cord-015306-us58wwmp 1940 36 cellular cellular JJ cord-015306-us58wwmp 1940 37 immune immune JJ cord-015306-us58wwmp 1940 38 deficiency deficiency NN cord-015306-us58wwmp 1940 39 and and CC cord-015306-us58wwmp 1940 40 radiologic radiologic JJ cord-015306-us58wwmp 1940 41 characteristics characteristic NNS cord-015306-us58wwmp 1940 42 of of IN cord-015306-us58wwmp 1940 43 spondyloepiphyseal spondyloepiphyseal JJ cord-015306-us58wwmp 1940 44 dysplasia dysplasia NN cord-015306-us58wwmp 1940 45 and and CC cord-015306-us58wwmp 1940 46 died die VBD cord-015306-us58wwmp 1940 47 at at IN cord-015306-us58wwmp 1940 48 the the DT cord-015306-us58wwmp 1940 49 age age NN cord-015306-us58wwmp 1940 50 of of IN cord-015306-us58wwmp 1940 51 16.5 16.5 CD cord-015306-us58wwmp 1940 52 years year NNS cord-015306-us58wwmp 1940 53 with with IN cord-015306-us58wwmp 1940 54 bone bone NN cord-015306-us58wwmp 1940 55 marrow marrow NN cord-015306-us58wwmp 1940 56 failure failure NN cord-015306-us58wwmp 1940 57 and and CC cord-015306-us58wwmp 1940 58 severe severe JJ cord-015306-us58wwmp 1940 59 pneumonia pneumonia NN cord-015306-us58wwmp 1940 60 . . . cord-015306-us58wwmp 1941 1 Conclusion conclusion NN cord-015306-us58wwmp 1941 2 : : : cord-015306-us58wwmp 1942 1 We -PRON- PRP cord-015306-us58wwmp 1942 2 emphasize emphasize VBP cord-015306-us58wwmp 1942 3 that that IN cord-015306-us58wwmp 1942 4 SIOD SIOD NNP cord-015306-us58wwmp 1942 5 is be VBZ cord-015306-us58wwmp 1942 6 to to TO cord-015306-us58wwmp 1942 7 be be VB cord-015306-us58wwmp 1942 8 considered consider VBN cord-015306-us58wwmp 1942 9 in in IN cord-015306-us58wwmp 1942 10 children child NNS cord-015306-us58wwmp 1942 11 with with IN cord-015306-us58wwmp 1942 12 growth growth NN cord-015306-us58wwmp 1942 13 retardation retardation NN cord-015306-us58wwmp 1942 14 , , , cord-015306-us58wwmp 1942 15 SRNS SRNS NNP cord-015306-us58wwmp 1942 16 and and CC cord-015306-us58wwmp 1942 17 bone bone NN cord-015306-us58wwmp 1942 18 abnormalities abnormality NNS cord-015306-us58wwmp 1942 19 and and CC cord-015306-us58wwmp 1942 20 that that DT cord-015306-us58wwmp 1942 21 inherited inherit VBD cord-015306-us58wwmp 1942 22 nephrotic nephrotic JJ cord-015306-us58wwmp 1942 23 syndrome syndrome NN cord-015306-us58wwmp 1942 24 may may MD cord-015306-us58wwmp 1942 25 be be VB cord-015306-us58wwmp 1942 26 presented present VBN cord-015306-us58wwmp 1942 27 in in IN cord-015306-us58wwmp 1942 28 late late JJ cord-015306-us58wwmp 1942 29 childhood childhood NN cord-015306-us58wwmp 1942 30 or or CC cord-015306-us58wwmp 1942 31 even even RB cord-015306-us58wwmp 1942 32 adolescence adolescence NN cord-015306-us58wwmp 1942 33 and and CC cord-015306-us58wwmp 1942 34 SIOD SIOD NNP cord-015306-us58wwmp 1942 35 suspected suspect VBD cord-015306-us58wwmp 1942 36 patients patient NNS cord-015306-us58wwmp 1942 37 even even RB cord-015306-us58wwmp 1942 38 before before IN cord-015306-us58wwmp 1942 39 full full JJ cord-015306-us58wwmp 1942 40 picture picture NN cord-015306-us58wwmp 1942 41 development development NN cord-015306-us58wwmp 1942 42 should should MD cord-015306-us58wwmp 1942 43 be be VB cord-015306-us58wwmp 1942 44 closely closely RB cord-015306-us58wwmp 1942 45 monitored monitor VBN cord-015306-us58wwmp 1942 46 for for IN cord-015306-us58wwmp 1942 47 proteinuria proteinuria NN cord-015306-us58wwmp 1942 48 , , , cord-015306-us58wwmp 1942 49 hypertension hypertension NN cord-015306-us58wwmp 1942 50 , , , cord-015306-us58wwmp 1942 51 cellular cellular JJ cord-015306-us58wwmp 1942 52 immunity immunity NN cord-015306-us58wwmp 1942 53 and and CC cord-015306-us58wwmp 1942 54 opportunistic opportunistic JJ cord-015306-us58wwmp 1942 55 infections infection NNS cord-015306-us58wwmp 1942 56 especially especially RB cord-015306-us58wwmp 1942 57 with with IN cord-015306-us58wwmp 1942 58 the the DT cord-015306-us58wwmp 1942 59 need need NN cord-015306-us58wwmp 1942 60 to to TO cord-015306-us58wwmp 1942 61 start start VB cord-015306-us58wwmp 1942 62 immune immune JJ cord-015306-us58wwmp 1942 63 suppressive suppressive JJ cord-015306-us58wwmp 1942 64 therapy therapy NN cord-015306-us58wwmp 1942 65 for for IN cord-015306-us58wwmp 1942 66 nephrotic nephrotic JJ cord-015306-us58wwmp 1942 67 syndrome syndrome NN cord-015306-us58wwmp 1942 68 . . . cord-015306-us58wwmp 1943 1 Abstract abstract JJ cord-015306-us58wwmp 1943 2 # # NN cord-015306-us58wwmp 1943 3 P p NN cord-015306-us58wwmp 1943 4 - - HYPH cord-015306-us58wwmp 1943 5 SAT244 SAT244 NNP cord-015306-us58wwmp 1943 6 Denys Denys NNP cord-015306-us58wwmp 1943 7 - - HYPH cord-015306-us58wwmp 1943 8 Drash Drash NNP cord-015306-us58wwmp 1943 9 syndrome syndrome NN cord-015306-us58wwmp 1943 10 presenting present VBG cord-015306-us58wwmp 1943 11 with with IN cord-015306-us58wwmp 1943 12 polycystic polycystic JJ cord-015306-us58wwmp 1943 13 kidneys kidney NNS cord-015306-us58wwmp 1943 14 Objective objective NN cord-015306-us58wwmp 1943 15 : : : cord-015306-us58wwmp 1944 1 Denys Denys NNP cord-015306-us58wwmp 1944 2 - - HYPH cord-015306-us58wwmp 1944 3 Drash Drash NNP cord-015306-us58wwmp 1944 4 syndrome syndrome NN cord-015306-us58wwmp 1944 5 ( ( -LRB- cord-015306-us58wwmp 1944 6 DDS DDS NNP cord-015306-us58wwmp 1944 7 ) ) -RRB- cord-015306-us58wwmp 1944 8 is be VBZ cord-015306-us58wwmp 1944 9 characterized characterize VBN cord-015306-us58wwmp 1944 10 by by IN cord-015306-us58wwmp 1944 11 a a DT cord-015306-us58wwmp 1944 12 congenital congenital JJ cord-015306-us58wwmp 1944 13 or or CC cord-015306-us58wwmp 1944 14 infantile infantile JJ cord-015306-us58wwmp 1944 15 nephrotic nephrotic JJ cord-015306-us58wwmp 1944 16 syndrome syndrome NN cord-015306-us58wwmp 1944 17 due due JJ cord-015306-us58wwmp 1944 18 to to TO cord-015306-us58wwmp 1944 19 diffuse diffuse VB cord-015306-us58wwmp 1944 20 mesangial mesangial JJ cord-015306-us58wwmp 1944 21 sclerosis sclerosis NN cord-015306-us58wwmp 1944 22 , , , cord-015306-us58wwmp 1944 23 male male JJ cord-015306-us58wwmp 1944 24 pseudohermaphroditism pseudohermaphroditism NN cord-015306-us58wwmp 1944 25 and and CC cord-015306-us58wwmp 1944 26 a a DT cord-015306-us58wwmp 1944 27 strong strong JJ cord-015306-us58wwmp 1944 28 predisposition predisposition NN cord-015306-us58wwmp 1944 29 to to TO cord-015306-us58wwmp 1944 30 develop develop VB cord-015306-us58wwmp 1944 31 Wilm Wilm NNP cord-015306-us58wwmp 1944 32 's 's POS cord-015306-us58wwmp 1944 33 tumors tumor NNS cord-015306-us58wwmp 1944 34 and and CC cord-015306-us58wwmp 1944 35 gonadoblastoma gonadoblastoma NNP cord-015306-us58wwmp 1944 36 's 's POS cord-015306-us58wwmp 1944 37 . . . cord-015306-us58wwmp 1945 1 The the DT cord-015306-us58wwmp 1945 2 syndrome syndrome NN cord-015306-us58wwmp 1945 3 is be VBZ cord-015306-us58wwmp 1945 4 caused cause VBN cord-015306-us58wwmp 1945 5 by by IN cord-015306-us58wwmp 1945 6 a a DT cord-015306-us58wwmp 1945 7 dominant dominant JJ cord-015306-us58wwmp 1945 8 mutation mutation NN cord-015306-us58wwmp 1945 9 in in IN cord-015306-us58wwmp 1945 10 the the DT cord-015306-us58wwmp 1945 11 WT1 WT1 NNP cord-015306-us58wwmp 1945 12 gene gene NN cord-015306-us58wwmp 1945 13 . . . cord-015306-us58wwmp 1946 1 We -PRON- PRP cord-015306-us58wwmp 1946 2 report report VBP cord-015306-us58wwmp 1946 3 a a DT cord-015306-us58wwmp 1946 4 case case NN cord-015306-us58wwmp 1946 5 of of IN cord-015306-us58wwmp 1946 6 DDS DDS NNP cord-015306-us58wwmp 1946 7 associated associate VBN cord-015306-us58wwmp 1946 8 with with IN cord-015306-us58wwmp 1946 9 renal renal JJ cord-015306-us58wwmp 1946 10 cysts cyst NNS cord-015306-us58wwmp 1946 11 , , , cord-015306-us58wwmp 1946 12 which which WDT cord-015306-us58wwmp 1946 13 has have VBZ cord-015306-us58wwmp 1946 14 never never RB cord-015306-us58wwmp 1946 15 been be VBN cord-015306-us58wwmp 1946 16 described describe VBN cord-015306-us58wwmp 1946 17 so so RB cord-015306-us58wwmp 1946 18 far far RB cord-015306-us58wwmp 1946 19 . . . cord-015306-us58wwmp 1947 1 We -PRON- PRP cord-015306-us58wwmp 1947 2 report report VBP cord-015306-us58wwmp 1947 3 a a DT cord-015306-us58wwmp 1947 4 case case NN cord-015306-us58wwmp 1947 5 of of IN cord-015306-us58wwmp 1947 6 DDS DDS NNP cord-015306-us58wwmp 1947 7 in in IN cord-015306-us58wwmp 1947 8 a a DT cord-015306-us58wwmp 1947 9 3 3 CD cord-015306-us58wwmp 1947 10 months month NNS cord-015306-us58wwmp 1947 11 old old JJ cord-015306-us58wwmp 1947 12 girl girl NN cord-015306-us58wwmp 1947 13 presenting present VBG cord-015306-us58wwmp 1947 14 with with IN cord-015306-us58wwmp 1947 15 proteinuria proteinuria NN cord-015306-us58wwmp 1947 16 and and CC cord-015306-us58wwmp 1947 17 bilateral bilateral JJ cord-015306-us58wwmp 1947 18 cortical cortical JJ cord-015306-us58wwmp 1947 19 cysts cyst NNS cord-015306-us58wwmp 1947 20 on on IN cord-015306-us58wwmp 1947 21 renal renal JJ cord-015306-us58wwmp 1947 22 ultrasound ultrasound NN cord-015306-us58wwmp 1947 23 . . . cord-015306-us58wwmp 1948 1 Autosomal autosomal JJ cord-015306-us58wwmp 1948 2 recessive recessive JJ cord-015306-us58wwmp 1948 3 polycystic polycystic JJ cord-015306-us58wwmp 1948 4 kidney kidney NN cord-015306-us58wwmp 1948 5 disease disease NN cord-015306-us58wwmp 1948 6 was be VBD cord-015306-us58wwmp 1948 7 excluded exclude VBN cord-015306-us58wwmp 1948 8 by by IN cord-015306-us58wwmp 1948 9 a a DT cord-015306-us58wwmp 1948 10 normal normal JJ cord-015306-us58wwmp 1948 11 liver liver NN cord-015306-us58wwmp 1948 12 biopsy biopsy NN cord-015306-us58wwmp 1948 13 . . . cord-015306-us58wwmp 1949 1 A a DT cord-015306-us58wwmp 1949 2 kidney kidney NN cord-015306-us58wwmp 1949 3 biopsy biopsy NN cord-015306-us58wwmp 1949 4 showed show VBD cord-015306-us58wwmp 1949 5 diffuse diffuse JJ cord-015306-us58wwmp 1949 6 mesangial mesangial JJ cord-015306-us58wwmp 1949 7 sclerosis sclerosis NN cord-015306-us58wwmp 1949 8 . . . cord-015306-us58wwmp 1950 1 At at IN cord-015306-us58wwmp 1950 2 the the DT cord-015306-us58wwmp 1950 3 age age NN cord-015306-us58wwmp 1950 4 of of IN cord-015306-us58wwmp 1950 5 7 7 CD cord-015306-us58wwmp 1950 6 months month NNS cord-015306-us58wwmp 1950 7 , , , cord-015306-us58wwmp 1950 8 she -PRON- PRP cord-015306-us58wwmp 1950 9 developed develop VBD cord-015306-us58wwmp 1950 10 a a DT cord-015306-us58wwmp 1950 11 unilateral unilateral JJ cord-015306-us58wwmp 1950 12 Wilm Wilm NNP cord-015306-us58wwmp 1950 13 's 's POS cord-015306-us58wwmp 1950 14 tumor tumor NN cord-015306-us58wwmp 1950 15 , , , cord-015306-us58wwmp 1950 16 which which WDT cord-015306-us58wwmp 1950 17 was be VBD cord-015306-us58wwmp 1950 18 treated treat VBN cord-015306-us58wwmp 1950 19 by by IN cord-015306-us58wwmp 1950 20 heminephrectomy heminephrectomy NN cord-015306-us58wwmp 1950 21 and and CC cord-015306-us58wwmp 1950 22 chemotherapy chemotherapy NN cord-015306-us58wwmp 1950 23 . . . cord-015306-us58wwmp 1951 1 The the DT cord-015306-us58wwmp 1951 2 renal renal JJ cord-015306-us58wwmp 1951 3 cysts cyst NNS cord-015306-us58wwmp 1951 4 were be VBD cord-015306-us58wwmp 1951 5 still still RB cord-015306-us58wwmp 1951 6 present present JJ cord-015306-us58wwmp 1951 7 on on IN cord-015306-us58wwmp 1951 8 ultrasound ultrasound NN cord-015306-us58wwmp 1951 9 . . . cord-015306-us58wwmp 1952 1 Histological histological JJ cord-015306-us58wwmp 1952 2 examination examination NN cord-015306-us58wwmp 1952 3 of of IN cord-015306-us58wwmp 1952 4 a a DT cord-015306-us58wwmp 1952 5 cyst cyst NN cord-015306-us58wwmp 1952 6 ( ( -LRB- cord-015306-us58wwmp 1952 7 located locate VBN cord-015306-us58wwmp 1952 8 in in IN cord-015306-us58wwmp 1952 9 the the DT cord-015306-us58wwmp 1952 10 resected resected JJ cord-015306-us58wwmp 1952 11 specimen specimen NN cord-015306-us58wwmp 1952 12 , , , cord-015306-us58wwmp 1952 13 but but CC cord-015306-us58wwmp 1952 14 separate separate JJ cord-015306-us58wwmp 1952 15 from from IN cord-015306-us58wwmp 1952 16 the the DT cord-015306-us58wwmp 1952 17 Wilm Wilm NNP cord-015306-us58wwmp 1952 18 's 's POS cord-015306-us58wwmp 1952 19 tumor tumor NN cord-015306-us58wwmp 1952 20 ) ) -RRB- cord-015306-us58wwmp 1952 21 showed show VBD cord-015306-us58wwmp 1952 22 one one CD cord-015306-us58wwmp 1952 23 layer layer NN cord-015306-us58wwmp 1952 24 of of IN cord-015306-us58wwmp 1952 25 flattened flatten VBN cord-015306-us58wwmp 1952 26 epithelial epithelial JJ cord-015306-us58wwmp 1952 27 cells cell NNS cord-015306-us58wwmp 1952 28 , , , cord-015306-us58wwmp 1952 29 without without IN cord-015306-us58wwmp 1952 30 any any DT cord-015306-us58wwmp 1952 31 evidence evidence NN cord-015306-us58wwmp 1952 32 of of IN cord-015306-us58wwmp 1952 33 malignancy malignancy NN cord-015306-us58wwmp 1952 34 . . . cord-015306-us58wwmp 1953 1 The the DT cord-015306-us58wwmp 1953 2 combination combination NN cord-015306-us58wwmp 1953 3 of of IN cord-015306-us58wwmp 1953 4 diffuse diffuse JJ cord-015306-us58wwmp 1953 5 mesangial mesangial JJ cord-015306-us58wwmp 1953 6 sclerosis sclerosis NN cord-015306-us58wwmp 1953 7 and and CC cord-015306-us58wwmp 1953 8 a a DT cord-015306-us58wwmp 1953 9 Wilm Wilm NNP cord-015306-us58wwmp 1953 10 's 's POS cord-015306-us58wwmp 1953 11 tumor tumor NN cord-015306-us58wwmp 1953 12 pointed point VBD cord-015306-us58wwmp 1953 13 to to IN cord-015306-us58wwmp 1953 14 the the DT cord-015306-us58wwmp 1953 15 diagnosis diagnosis NN cord-015306-us58wwmp 1953 16 of of IN cord-015306-us58wwmp 1953 17 DDS DDS NNP cord-015306-us58wwmp 1953 18 . . . cord-015306-us58wwmp 1954 1 Genetic genetic JJ cord-015306-us58wwmp 1954 2 analysis analysis NN cord-015306-us58wwmp 1954 3 showed show VBD cord-015306-us58wwmp 1954 4 a a DT cord-015306-us58wwmp 1954 5 de de FW cord-015306-us58wwmp 1954 6 novo novo NNP cord-015306-us58wwmp 1954 7 heterozygous heterozygous JJ cord-015306-us58wwmp 1954 8 missense missense NNP cord-015306-us58wwmp 1954 9 mutation mutation NN cord-015306-us58wwmp 1955 1 c.1186G c.1186G NFP cord-015306-us58wwmp 1955 2 > > XX cord-015306-us58wwmp 1955 3 A a NN cord-015306-us58wwmp 1955 4 ( ( -LRB- cord-015306-us58wwmp 1955 5 p. p. NN cord-015306-us58wwmp 1956 1 Asp396Asn asp396asn LS cord-015306-us58wwmp 1956 2 ) ) -RRB- cord-015306-us58wwmp 1956 3 in in IN cord-015306-us58wwmp 1956 4 the the DT cord-015306-us58wwmp 1956 5 WT1 WT1 NNP cord-015306-us58wwmp 1956 6 gene gene NN cord-015306-us58wwmp 1956 7 , , , cord-015306-us58wwmp 1956 8 previously previously RB cord-015306-us58wwmp 1956 9 described describe VBN cord-015306-us58wwmp 1956 10 in in IN cord-015306-us58wwmp 1956 11 patients patient NNS cord-015306-us58wwmp 1956 12 with with IN cord-015306-us58wwmp 1956 13 DDS DDS NNP cord-015306-us58wwmp 1956 14 , , , cord-015306-us58wwmp 1956 15 confirming confirm VBG cord-015306-us58wwmp 1956 16 the the DT cord-015306-us58wwmp 1956 17 diagnosis diagnosis NN cord-015306-us58wwmp 1956 18 . . . cord-015306-us58wwmp 1957 1 Because because IN cord-015306-us58wwmp 1957 2 polycystic polycystic JJ cord-015306-us58wwmp 1957 3 kidneys kidney NNS cord-015306-us58wwmp 1957 4 have have VBP cord-015306-us58wwmp 1957 5 never never RB cord-015306-us58wwmp 1957 6 been be VBN cord-015306-us58wwmp 1957 7 reported report VBN cord-015306-us58wwmp 1957 8 in in IN cord-015306-us58wwmp 1957 9 DDS DDS NNP cord-015306-us58wwmp 1957 10 , , , cord-015306-us58wwmp 1957 11 we -PRON- PRP cord-015306-us58wwmp 1957 12 explored explore VBD cord-015306-us58wwmp 1957 13 several several JJ cord-015306-us58wwmp 1957 14 genes gene NNS cord-015306-us58wwmp 1957 15 responsible responsible JJ cord-015306-us58wwmp 1957 16 for for IN cord-015306-us58wwmp 1957 17 these these DT cord-015306-us58wwmp 1957 18 renal renal JJ cord-015306-us58wwmp 1957 19 manifestations manifestation NNS cord-015306-us58wwmp 1957 20 , , , cord-015306-us58wwmp 1957 21 such such JJ cord-015306-us58wwmp 1957 22 as as IN cord-015306-us58wwmp 1957 23 HNF-1β HNF-1β NNP cord-015306-us58wwmp 1957 24 , , , cord-015306-us58wwmp 1957 25 PAX2 PAX2 NNP cord-015306-us58wwmp 1957 26 , , , cord-015306-us58wwmp 1957 27 PKD1 PKD1 NNP cord-015306-us58wwmp 1957 28 and and CC cord-015306-us58wwmp 1957 29 PKD2 PKD2 NNP cord-015306-us58wwmp 1957 30 . . . cord-015306-us58wwmp 1958 1 Remarkably remarkably RB cord-015306-us58wwmp 1958 2 , , , cord-015306-us58wwmp 1958 3 we -PRON- PRP cord-015306-us58wwmp 1958 4 identified identify VBD cord-015306-us58wwmp 1958 5 a a DT cord-015306-us58wwmp 1958 6 heterozygous heterozygous JJ cord-015306-us58wwmp 1958 7 missense missense NN cord-015306-us58wwmp 1958 8 variant variant NN cord-015306-us58wwmp 1959 1 c.12439A c.12439A NFP cord-015306-us58wwmp 1959 2 > > XX cord-015306-us58wwmp 1959 3 G g NN cord-015306-us58wwmp 1959 4 ( ( -LRB- cord-015306-us58wwmp 1959 5 p p NN cord-015306-us58wwmp 1959 6 . . . cord-015306-us58wwmp 1959 7 Lys4147Glu Lys4147Glu NNP cord-015306-us58wwmp 1959 8 ) ) -RRB- cord-015306-us58wwmp 1959 9 in in IN cord-015306-us58wwmp 1959 10 the the DT cord-015306-us58wwmp 1959 11 PKD1 PKD1 NNP cord-015306-us58wwmp 1959 12 gene gene NN cord-015306-us58wwmp 1959 13 . . . cord-015306-us58wwmp 1960 1 Mutations mutation NNS cord-015306-us58wwmp 1960 2 in in IN cord-015306-us58wwmp 1960 3 PKD1 PKD1 NNP cord-015306-us58wwmp 1960 4 lead lead NN cord-015306-us58wwmp 1960 5 to to IN cord-015306-us58wwmp 1960 6 autosomal autosomal JJ cord-015306-us58wwmp 1960 7 dominant dominant JJ cord-015306-us58wwmp 1960 8 polycystic polycystic JJ cord-015306-us58wwmp 1960 9 kidney kidney NN cord-015306-us58wwmp 1960 10 disease disease NN cord-015306-us58wwmp 1960 11 ( ( -LRB- cord-015306-us58wwmp 1960 12 ADPKD ADPKD NNP cord-015306-us58wwmp 1960 13 ) ) -RRB- cord-015306-us58wwmp 1960 14 . . . cord-015306-us58wwmp 1961 1 The the DT cord-015306-us58wwmp 1961 2 pathogenicity pathogenicity NN cord-015306-us58wwmp 1961 3 of of IN cord-015306-us58wwmp 1961 4 the the DT cord-015306-us58wwmp 1961 5 newly newly RB cord-015306-us58wwmp 1961 6 identified identify VBN cord-015306-us58wwmp 1961 7 missense missense NN cord-015306-us58wwmp 1961 8 variant variant NN cord-015306-us58wwmp 1961 9 in in IN cord-015306-us58wwmp 1961 10 our -PRON- PRP$ cord-015306-us58wwmp 1961 11 case case NN cord-015306-us58wwmp 1961 12 was be VBD cord-015306-us58wwmp 1961 13 evaluated evaluate VBN cord-015306-us58wwmp 1961 14 by by IN cord-015306-us58wwmp 1961 15 different different JJ cord-015306-us58wwmp 1961 16 mutation mutation NN cord-015306-us58wwmp 1961 17 prediction prediction NN cord-015306-us58wwmp 1961 18 software software NN cord-015306-us58wwmp 1961 19 programs program NNS cord-015306-us58wwmp 1961 20 and and CC cord-015306-us58wwmp 1961 21 was be VBD cord-015306-us58wwmp 1961 22 classified classify VBN cord-015306-us58wwmp 1961 23 as as IN cord-015306-us58wwmp 1961 24 being be VBG cord-015306-us58wwmp 1961 25 ' ' `` cord-015306-us58wwmp 1961 26 likely likely RB cord-015306-us58wwmp 1961 27 pathogenic pathogenic JJ cord-015306-us58wwmp 1961 28 ' ' '' cord-015306-us58wwmp 1961 29 . . . cord-015306-us58wwmp 1962 1 The the DT cord-015306-us58wwmp 1962 2 same same JJ cord-015306-us58wwmp 1962 3 variant variant NN cord-015306-us58wwmp 1962 4 was be VBD cord-015306-us58wwmp 1962 5 found find VBN cord-015306-us58wwmp 1962 6 in in IN cord-015306-us58wwmp 1962 7 the the DT cord-015306-us58wwmp 1962 8 patient patient NN cord-015306-us58wwmp 1962 9 's 's POS cord-015306-us58wwmp 1962 10 mother mother NN cord-015306-us58wwmp 1962 11 , , , cord-015306-us58wwmp 1962 12 having have VBG cord-015306-us58wwmp 1962 13 no no DT cord-015306-us58wwmp 1962 14 renal renal JJ cord-015306-us58wwmp 1962 15 cysts cyst NNS cord-015306-us58wwmp 1962 16 on on IN cord-015306-us58wwmp 1962 17 ultrasound ultrasound NN cord-015306-us58wwmp 1962 18 and and CC cord-015306-us58wwmp 1962 19 in in IN cord-015306-us58wwmp 1962 20 the the DT cord-015306-us58wwmp 1962 21 grandfather grandfather NN cord-015306-us58wwmp 1962 22 , , , cord-015306-us58wwmp 1962 23 having have VBG cord-015306-us58wwmp 1962 24 bilaterally bilaterally RB cord-015306-us58wwmp 1962 25 renal renal JJ cord-015306-us58wwmp 1962 26 cysts cyst NNS cord-015306-us58wwmp 1962 27 . . . cord-015306-us58wwmp 1963 1 Conclusion conclusion NN cord-015306-us58wwmp 1963 2 : : : cord-015306-us58wwmp 1963 3 This this DT cord-015306-us58wwmp 1963 4 is be VBZ cord-015306-us58wwmp 1963 5 the the DT cord-015306-us58wwmp 1963 6 first first JJ cord-015306-us58wwmp 1963 7 case case NN cord-015306-us58wwmp 1963 8 of of IN cord-015306-us58wwmp 1963 9 DDS DDS NNP cord-015306-us58wwmp 1963 10 in in IN cord-015306-us58wwmp 1963 11 combination combination NN cord-015306-us58wwmp 1963 12 with with IN cord-015306-us58wwmp 1963 13 polycystic polycystic JJ cord-015306-us58wwmp 1963 14 kidneys kidney NNS cord-015306-us58wwmp 1963 15 . . . cord-015306-us58wwmp 1964 1 We -PRON- PRP cord-015306-us58wwmp 1964 2 hypothesize hypothesize VBP cord-015306-us58wwmp 1964 3 that that IN cord-015306-us58wwmp 1964 4 PKD1 PKD1 NNP cord-015306-us58wwmp 1965 1 c.12439A c.12439A NFP cord-015306-us58wwmp 1965 2 > > XX cord-015306-us58wwmp 1965 3 G g NN cord-015306-us58wwmp 1965 4 variant variant NN cord-015306-us58wwmp 1965 5 might may MD cord-015306-us58wwmp 1965 6 be be VB cord-015306-us58wwmp 1965 7 an an DT cord-015306-us58wwmp 1965 8 incompletely incompletely RB cord-015306-us58wwmp 1965 9 penetrant penetrant JJ cord-015306-us58wwmp 1965 10 allele allele NN cord-015306-us58wwmp 1965 11 that that WDT cord-015306-us58wwmp 1965 12 can can MD cord-015306-us58wwmp 1965 13 cause cause VB cord-015306-us58wwmp 1965 14 a a DT cord-015306-us58wwmp 1965 15 severe severe JJ cord-015306-us58wwmp 1965 16 phenotype phenotype NN cord-015306-us58wwmp 1965 17 of of IN cord-015306-us58wwmp 1965 18 ADPKD ADPKD NNP cord-015306-us58wwmp 1965 19 in in IN cord-015306-us58wwmp 1965 20 association association NN cord-015306-us58wwmp 1965 21 with with IN cord-015306-us58wwmp 1965 22 a a DT cord-015306-us58wwmp 1965 23 WT1 WT1 NNP cord-015306-us58wwmp 1965 24 gene gene NN cord-015306-us58wwmp 1965 25 mutation mutation NN cord-015306-us58wwmp 1965 26 . . . cord-015306-us58wwmp 1966 1 The the DT cord-015306-us58wwmp 1966 2 phosphatase phosphatase NN cord-015306-us58wwmp 1966 3 and and CC cord-015306-us58wwmp 1966 4 tensine tensine JJ cord-015306-us58wwmp 1966 5 homolog homolog NN cord-015306-us58wwmp 1966 6 ( ( -LRB- cord-015306-us58wwmp 1966 7 PTEN PTEN NNP cord-015306-us58wwmp 1966 8 ) ) -RRB- cord-015306-us58wwmp 1966 9 gene gene NN cord-015306-us58wwmp 1966 10 is be VBZ cord-015306-us58wwmp 1966 11 a a DT cord-015306-us58wwmp 1966 12 tumor tumor NN cord-015306-us58wwmp 1966 13 suppressor suppressor NN cord-015306-us58wwmp 1966 14 gene gene NN cord-015306-us58wwmp 1966 15 located locate VBN cord-015306-us58wwmp 1966 16 on on IN cord-015306-us58wwmp 1966 17 the the DT cord-015306-us58wwmp 1966 18 long long JJ cord-015306-us58wwmp 1966 19 arm arm NN cord-015306-us58wwmp 1966 20 of of IN cord-015306-us58wwmp 1966 21 chromosome chromosome NN cord-015306-us58wwmp 1966 22 10 10 CD cord-015306-us58wwmp 1967 1 ( ( -LRB- cord-015306-us58wwmp 1967 2 10q22 10q22 CD cord-015306-us58wwmp 1967 3 - - SYM cord-015306-us58wwmp 1967 4 23 23 CD cord-015306-us58wwmp 1967 5 ) ) -RRB- cord-015306-us58wwmp 1967 6 . . . cord-015306-us58wwmp 1968 1 The the DT cord-015306-us58wwmp 1968 2 PTEN PTEN NNP cord-015306-us58wwmp 1968 3 protein protein NN cord-015306-us58wwmp 1968 4 is be VBZ cord-015306-us58wwmp 1968 5 broadly broadly RB cord-015306-us58wwmp 1968 6 expressed express VBN cord-015306-us58wwmp 1968 7 in in IN cord-015306-us58wwmp 1968 8 cells cell NNS cord-015306-us58wwmp 1968 9 throughout throughout IN cord-015306-us58wwmp 1968 10 the the DT cord-015306-us58wwmp 1968 11 body body NN cord-015306-us58wwmp 1968 12 , , , cord-015306-us58wwmp 1968 13 acting act VBG cord-015306-us58wwmp 1968 14 as as IN cord-015306-us58wwmp 1968 15 both both CC cord-015306-us58wwmp 1968 16 lipid lipid NN cord-015306-us58wwmp 1968 17 and and CC cord-015306-us58wwmp 1968 18 protein protein NN cord-015306-us58wwmp 1968 19 phosphatases phosphatase NNS cord-015306-us58wwmp 1968 20 , , , cord-015306-us58wwmp 1968 21 and and CC cord-015306-us58wwmp 1968 22 regulates regulate VBZ cord-015306-us58wwmp 1968 23 intracellular intracellular JJ cord-015306-us58wwmp 1968 24 signaling signal VBG cord-015306-us58wwmp 1968 25 via via IN cord-015306-us58wwmp 1968 26 various various JJ cord-015306-us58wwmp 1968 27 pathways pathway NNS cord-015306-us58wwmp 1968 28 . . . cord-015306-us58wwmp 1969 1 Reduced reduce VBN cord-015306-us58wwmp 1969 2 PTEN PTEN NNP cord-015306-us58wwmp 1969 3 protein protein NN cord-015306-us58wwmp 1969 4 resulting result VBG cord-015306-us58wwmp 1969 5 from from IN cord-015306-us58wwmp 1969 6 a a DT cord-015306-us58wwmp 1969 7 PTEN PTEN NNP cord-015306-us58wwmp 1969 8 gene gene NN cord-015306-us58wwmp 1969 9 mutation mutation NN cord-015306-us58wwmp 1969 10 may may MD cord-015306-us58wwmp 1969 11 enhance enhance VB cord-015306-us58wwmp 1969 12 cell cell NN cord-015306-us58wwmp 1969 13 proliferation proliferation NN cord-015306-us58wwmp 1969 14 , , , cord-015306-us58wwmp 1969 15 resist resist VBP cord-015306-us58wwmp 1969 16 from from IN cord-015306-us58wwmp 1969 17 apoptosis apoptosis NN cord-015306-us58wwmp 1969 18 . . . cord-015306-us58wwmp 1970 1 In in IN cord-015306-us58wwmp 1970 2 addition addition NN cord-015306-us58wwmp 1970 3 , , , cord-015306-us58wwmp 1970 4 it -PRON- PRP cord-015306-us58wwmp 1970 5 has have VBZ cord-015306-us58wwmp 1970 6 became become VBN cord-015306-us58wwmp 1970 7 clear clear JJ cord-015306-us58wwmp 1970 8 that that IN cord-015306-us58wwmp 1970 9 , , , cord-015306-us58wwmp 1970 10 in in IN cord-015306-us58wwmp 1970 11 vascular vascular JJ cord-015306-us58wwmp 1970 12 endothelial endothelial JJ cord-015306-us58wwmp 1970 13 cells cell NNS cord-015306-us58wwmp 1970 14 , , , cord-015306-us58wwmp 1970 15 PTEN PTEN NNP cord-015306-us58wwmp 1970 16 gene gene NN cord-015306-us58wwmp 1970 17 abnormalities abnormality NNS cord-015306-us58wwmp 1970 18 lead lead VBP cord-015306-us58wwmp 1970 19 to to IN cord-015306-us58wwmp 1970 20 increased increase VBN cord-015306-us58wwmp 1970 21 expressions expression NNS cord-015306-us58wwmp 1970 22 of of IN cord-015306-us58wwmp 1970 23 vascular vascular JJ cord-015306-us58wwmp 1970 24 growth growth NN cord-015306-us58wwmp 1970 25 factors factor NNS cord-015306-us58wwmp 1970 26 , , , cord-015306-us58wwmp 1970 27 such such JJ cord-015306-us58wwmp 1970 28 as as IN cord-015306-us58wwmp 1970 29 angiotensin angiotensin NN cord-015306-us58wwmp 1970 30 II II NNP cord-015306-us58wwmp 1970 31 ( ( -LRB- cord-015306-us58wwmp 1970 32 Ang Ang NNP cord-015306-us58wwmp 1970 33 II II NNP cord-015306-us58wwmp 1970 34 ) ) -RRB- cord-015306-us58wwmp 1970 35 , , , cord-015306-us58wwmp 1970 36 that that WDT cord-015306-us58wwmp 1970 37 are be VBP cord-015306-us58wwmp 1970 38 essential essential JJ cord-015306-us58wwmp 1970 39 to to IN cord-015306-us58wwmp 1970 40 angiogenesis angiogenesis NN cord-015306-us58wwmp 1970 41 . . . cord-015306-us58wwmp 1971 1 Recent recent JJ cord-015306-us58wwmp 1971 2 reports report NNS cord-015306-us58wwmp 1971 3 revealed reveal VBD cord-015306-us58wwmp 1971 4 a a DT cord-015306-us58wwmp 1971 5 germline germline JJ cord-015306-us58wwmp 1971 6 mutation mutation NN cord-015306-us58wwmp 1971 7 of of IN cord-015306-us58wwmp 1971 8 the the DT cord-015306-us58wwmp 1971 9 PTEN PTEN NNP cord-015306-us58wwmp 1971 10 gene gene NN cord-015306-us58wwmp 1971 11 to to TO cord-015306-us58wwmp 1971 12 cause cause VB cord-015306-us58wwmp 1971 13 several several JJ cord-015306-us58wwmp 1971 14 syndromes syndrome NNS cord-015306-us58wwmp 1971 15 with with IN cord-015306-us58wwmp 1971 16 generalized generalized JJ cord-015306-us58wwmp 1971 17 , , , cord-015306-us58wwmp 1971 18 multiple multiple JJ cord-015306-us58wwmp 1971 19 hamartomatous hamartomatous JJ cord-015306-us58wwmp 1971 20 lesions lesion NNS cord-015306-us58wwmp 1971 21 of of IN cord-015306-us58wwmp 1971 22 tridermic tridermic JJ cord-015306-us58wwmp 1971 23 origin origin NN cord-015306-us58wwmp 1971 24 . . . cord-015306-us58wwmp 1972 1 Thus thus RB cord-015306-us58wwmp 1972 2 , , , cord-015306-us58wwmp 1972 3 the the DT cord-015306-us58wwmp 1972 4 new new JJ cord-015306-us58wwmp 1972 5 concept concept NN cord-015306-us58wwmp 1972 6 of of IN cord-015306-us58wwmp 1972 7 PTEN PTEN NNP cord-015306-us58wwmp 1972 8 hamartoma hamartoma NNP cord-015306-us58wwmp 1972 9 tumor tumor NN cord-015306-us58wwmp 1972 10 syndrome syndrome NN cord-015306-us58wwmp 1972 11 ( ( -LRB- cord-015306-us58wwmp 1972 12 PHTS PHTS NNP cord-015306-us58wwmp 1972 13 ) ) -RRB- cord-015306-us58wwmp 1972 14 has have VBZ cord-015306-us58wwmp 1972 15 been be VBN cord-015306-us58wwmp 1972 16 proposed propose VBN cord-015306-us58wwmp 1972 17 . . . cord-015306-us58wwmp 1973 1 To to IN cord-015306-us58wwmp 1973 2 the the DT cord-015306-us58wwmp 1973 3 best good JJS cord-015306-us58wwmp 1973 4 of of IN cord-015306-us58wwmp 1973 5 our -PRON- PRP$ cord-015306-us58wwmp 1973 6 knowledge knowledge NN cord-015306-us58wwmp 1973 7 , , , cord-015306-us58wwmp 1973 8 we -PRON- PRP cord-015306-us58wwmp 1973 9 describe describe VBP cord-015306-us58wwmp 1973 10 here here RB cord-015306-us58wwmp 1973 11 for for IN cord-015306-us58wwmp 1973 12 the the DT cord-015306-us58wwmp 1973 13 first first JJ cord-015306-us58wwmp 1973 14 time time NN cord-015306-us58wwmp 1973 15 a a DT cord-015306-us58wwmp 1973 16 case case NN cord-015306-us58wwmp 1973 17 of of IN cord-015306-us58wwmp 1973 18 focal focal JJ cord-015306-us58wwmp 1973 19 segmental segmental JJ cord-015306-us58wwmp 1973 20 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 1973 21 ( ( -LRB- cord-015306-us58wwmp 1973 22 FSGS FSGS NNP cord-015306-us58wwmp 1973 23 ) ) -RRB- cord-015306-us58wwmp 1973 24 with with IN cord-015306-us58wwmp 1973 25 PHTS PHTS NNP cord-015306-us58wwmp 1973 26 . . . cord-015306-us58wwmp 1974 1 A a DT cord-015306-us58wwmp 1974 2 3-year 3-year JJ cord-015306-us58wwmp 1974 3 - - HYPH cord-015306-us58wwmp 1974 4 old old JJ cord-015306-us58wwmp 1974 5 girl girl NN cord-015306-us58wwmp 1974 6 was be VBD cord-015306-us58wwmp 1974 7 found find VBN cord-015306-us58wwmp 1974 8 to to TO cord-015306-us58wwmp 1974 9 have have VB cord-015306-us58wwmp 1974 10 proteinuria proteinuria NN cord-015306-us58wwmp 1974 11 and and CC cord-015306-us58wwmp 1974 12 hematuria hematuria NN cord-015306-us58wwmp 1974 13 on on IN cord-015306-us58wwmp 1974 14 health health NN cord-015306-us58wwmp 1974 15 examination examination NN cord-015306-us58wwmp 1974 16 and and CC cord-015306-us58wwmp 1974 17 referred refer VBD cord-015306-us58wwmp 1974 18 to to IN cord-015306-us58wwmp 1974 19 us -PRON- PRP cord-015306-us58wwmp 1974 20 for for IN cord-015306-us58wwmp 1974 21 persistent persistent JJ cord-015306-us58wwmp 1974 22 urinary urinary JJ cord-015306-us58wwmp 1974 23 abnormalities abnormality NNS cord-015306-us58wwmp 1974 24 . . . cord-015306-us58wwmp 1975 1 IgM IgM NNP cord-015306-us58wwmp 1975 2 nephropathy nephropathy NNP cord-015306-us58wwmp 1975 3 were be VBD cord-015306-us58wwmp 1975 4 diagnosed diagnose VBN cord-015306-us58wwmp 1975 5 by by IN cord-015306-us58wwmp 1975 6 renal renal JJ cord-015306-us58wwmp 1975 7 biopsy biopsy NN cord-015306-us58wwmp 1975 8 , , , cord-015306-us58wwmp 1975 9 and and CC cord-015306-us58wwmp 1975 10 she -PRON- PRP cord-015306-us58wwmp 1975 11 started start VBD cord-015306-us58wwmp 1975 12 taking take VBG cord-015306-us58wwmp 1975 13 an an DT cord-015306-us58wwmp 1975 14 angiotensin angiotensin NN cord-015306-us58wwmp 1975 15 - - HYPH cord-015306-us58wwmp 1975 16 converting convert VBG cord-015306-us58wwmp 1975 17 enzyme enzyme NN cord-015306-us58wwmp 1975 18 inhibitor inhibitor NN cord-015306-us58wwmp 1975 19 . . . cord-015306-us58wwmp 1976 1 However however RB cord-015306-us58wwmp 1976 2 , , , cord-015306-us58wwmp 1976 3 proteinuria proteinuria NN cord-015306-us58wwmp 1976 4 was be VBD cord-015306-us58wwmp 1976 5 not not RB cord-015306-us58wwmp 1976 6 reduced reduce VBN cord-015306-us58wwmp 1976 7 , , , cord-015306-us58wwmp 1976 8 and and CC cord-015306-us58wwmp 1976 9 an an DT cord-015306-us58wwmp 1976 10 oral oral JJ cord-015306-us58wwmp 1976 11 angiotensin angiotensin NN cord-015306-us58wwmp 1976 12 II II NNP cord-015306-us58wwmp 1976 13 receptor receptor NN cord-015306-us58wwmp 1976 14 blocker blocker NN cord-015306-us58wwmp 1976 15 ( ( -LRB- cord-015306-us58wwmp 1976 16 ARB ARB NNP cord-015306-us58wwmp 1976 17 ) ) -RRB- cord-015306-us58wwmp 1976 18 was be VBD cord-015306-us58wwmp 1976 19 administered administer VBN cord-015306-us58wwmp 1976 20 . . . cord-015306-us58wwmp 1977 1 Proteinuria Proteinuria NNP cord-015306-us58wwmp 1977 2 persisted persist VBD cord-015306-us58wwmp 1977 3 and and CC cord-015306-us58wwmp 1977 4 she -PRON- PRP cord-015306-us58wwmp 1977 5 underwent undergo VBD cord-015306-us58wwmp 1977 6 renal renal JJ cord-015306-us58wwmp 1977 7 biopsy biopsy NN cord-015306-us58wwmp 1977 8 again again RB cord-015306-us58wwmp 1977 9 , , , cord-015306-us58wwmp 1977 10 yielding yield VBG cord-015306-us58wwmp 1977 11 a a DT cord-015306-us58wwmp 1977 12 diagnosis diagnosis NN cord-015306-us58wwmp 1977 13 of of IN cord-015306-us58wwmp 1977 14 FSGS FSGS NNP cord-015306-us58wwmp 1977 15 . . . cord-015306-us58wwmp 1978 1 Despite despite IN cord-015306-us58wwmp 1978 2 continued continued JJ cord-015306-us58wwmp 1978 3 oral oral JJ cord-015306-us58wwmp 1978 4 ARB ARB NNP cord-015306-us58wwmp 1978 5 treatment treatment NN cord-015306-us58wwmp 1978 6 , , , cord-015306-us58wwmp 1978 7 proteinuria proteinuria NN cord-015306-us58wwmp 1978 8 is be VBZ cord-015306-us58wwmp 1978 9 ongoing ongoing JJ cord-015306-us58wwmp 1978 10 with with IN cord-015306-us58wwmp 1978 11 a a DT cord-015306-us58wwmp 1978 12 urine urine NN cord-015306-us58wwmp 1978 13 protein protein NN cord-015306-us58wwmp 1978 14 - - HYPH cord-015306-us58wwmp 1978 15 to to IN cord-015306-us58wwmp 1978 16 - - HYPH cord-015306-us58wwmp 1978 17 creatinine creatinine NN cord-015306-us58wwmp 1978 18 ratio ratio NN cord-015306-us58wwmp 1978 19 of of IN cord-015306-us58wwmp 1978 20 approximately approximately RB cord-015306-us58wwmp 1978 21 0.5 0.5 CD cord-015306-us58wwmp 1978 22 , , , cord-015306-us58wwmp 1978 23 and and CC cord-015306-us58wwmp 1978 24 mild mild JJ cord-015306-us58wwmp 1978 25 renal renal JJ cord-015306-us58wwmp 1978 26 impairment impairment NN cord-015306-us58wwmp 1978 27 . . . cord-015306-us58wwmp 1979 1 At at IN cord-015306-us58wwmp 1979 2 age age NN cord-015306-us58wwmp 1979 3 13 13 CD cord-015306-us58wwmp 1979 4 years year NNS cord-015306-us58wwmp 1979 5 , , , cord-015306-us58wwmp 1979 6 2 2 CD cord-015306-us58wwmp 1979 7 years year NNS cord-015306-us58wwmp 1979 8 ago ago RB cord-015306-us58wwmp 1979 9 , , , cord-015306-us58wwmp 1979 10 a a DT cord-015306-us58wwmp 1979 11 neck neck NN cord-015306-us58wwmp 1979 12 mass mass NN cord-015306-us58wwmp 1979 13 prompted prompt VBD cord-015306-us58wwmp 1979 14 a a DT cord-015306-us58wwmp 1979 15 detailed detailed JJ cord-015306-us58wwmp 1979 16 examination examination NN cord-015306-us58wwmp 1979 17 which which WDT cord-015306-us58wwmp 1979 18 revealed reveal VBD cord-015306-us58wwmp 1979 19 multiple multiple JJ cord-015306-us58wwmp 1979 20 thyroid thyroid NN cord-015306-us58wwmp 1979 21 nodules nodule NNS cord-015306-us58wwmp 1979 22 , , , cord-015306-us58wwmp 1979 23 ovarian ovarian JJ cord-015306-us58wwmp 1979 24 cysts cyst NNS cord-015306-us58wwmp 1979 25 ( ( -LRB- cord-015306-us58wwmp 1979 26 mucinous mucinous NNP cord-015306-us58wwmp 1979 27 cystadenoma cystadenoma NNP cord-015306-us58wwmp 1979 28 ) ) -RRB- cord-015306-us58wwmp 1979 29 , , , cord-015306-us58wwmp 1979 30 hemangiomas hemangiomas NNP cord-015306-us58wwmp 1979 31 in in IN cord-015306-us58wwmp 1979 32 the the DT cord-015306-us58wwmp 1979 33 plantar plantar JJ cord-015306-us58wwmp 1979 34 and and CC cord-015306-us58wwmp 1979 35 femoral femoral JJ cord-015306-us58wwmp 1979 36 regions region NNS cord-015306-us58wwmp 1979 37 , , , cord-015306-us58wwmp 1979 38 spinal spinal JJ cord-015306-us58wwmp 1979 39 cord cord NN cord-015306-us58wwmp 1979 40 lipoma lipoma NN cord-015306-us58wwmp 1979 41 , , , cord-015306-us58wwmp 1979 42 and and CC cord-015306-us58wwmp 1979 43 renal renal JJ cord-015306-us58wwmp 1979 44 nodular nodular JJ cord-015306-us58wwmp 1979 45 lesions lesion NNS cord-015306-us58wwmp 1979 46 , , , cord-015306-us58wwmp 1979 47 necessitating necessitate VBG cord-015306-us58wwmp 1979 48 follow follow NN cord-015306-us58wwmp 1979 49 - - HYPH cord-015306-us58wwmp 1979 50 up up NN cord-015306-us58wwmp 1979 51 . . . cord-015306-us58wwmp 1980 1 Subsequently subsequently RB cord-015306-us58wwmp 1980 2 , , , cord-015306-us58wwmp 1980 3 additional additional JJ cord-015306-us58wwmp 1980 4 workup workup NN cord-015306-us58wwmp 1980 5 detected detect VBD cord-015306-us58wwmp 1980 6 a a DT cord-015306-us58wwmp 1980 7 PTEN PTEN NNP cord-015306-us58wwmp 1980 8 gene gene NN cord-015306-us58wwmp 1980 9 heterozygous heterozygous JJ cord-015306-us58wwmp 1980 10 mutation mutation NN cord-015306-us58wwmp 1980 11 ( ( -LRB- cord-015306-us58wwmp 1980 12 exon exon NN cord-015306-us58wwmp 1980 13 8 8 CD cord-015306-us58wwmp 1980 14 codon codon NN cord-015306-us58wwmp 1980 15 335 335 CD cord-015306-us58wwmp 1980 16 CGA(Arg CGA(Arg NNP cord-015306-us58wwmp 1980 17 ) ) -RRB- cord-015306-us58wwmp 1980 18 TGA(STOP TGA(STOP NNP cord-015306-us58wwmp 1980 19 ) ) -RRB- cord-015306-us58wwmp 1980 20 ) ) -RRB- cord-015306-us58wwmp 1980 21 and and CC cord-015306-us58wwmp 1980 22 she -PRON- PRP cord-015306-us58wwmp 1980 23 was be VBD cord-015306-us58wwmp 1980 24 diagnosed diagnose VBN cord-015306-us58wwmp 1980 25 with with IN cord-015306-us58wwmp 1980 26 PHTS PHTS NNP cord-015306-us58wwmp 1980 27 . . . cord-015306-us58wwmp 1981 1 Methods method NNS cord-015306-us58wwmp 1981 2 : : : cord-015306-us58wwmp 1982 1 A a DT cord-015306-us58wwmp 1982 2 7-day 7-day JJ cord-015306-us58wwmp 1982 3 - - HYPH cord-015306-us58wwmp 1982 4 old old JJ cord-015306-us58wwmp 1982 5 girl girl NN cord-015306-us58wwmp 1982 6 , , , cord-015306-us58wwmp 1982 7 the the DT cord-015306-us58wwmp 1982 8 first first JJ cord-015306-us58wwmp 1982 9 child child NN cord-015306-us58wwmp 1982 10 of of IN cord-015306-us58wwmp 1982 11 non non JJ cord-015306-us58wwmp 1982 12 - - JJ cord-015306-us58wwmp 1982 13 consanguineous consanguineous JJ cord-015306-us58wwmp 1982 14 Chinese chinese JJ cord-015306-us58wwmp 1982 15 parents parent NNS cord-015306-us58wwmp 1982 16 , , , cord-015306-us58wwmp 1982 17 was be VBD cord-015306-us58wwmp 1982 18 hospitalized hospitalize VBN cord-015306-us58wwmp 1982 19 due due IN cord-015306-us58wwmp 1982 20 to to IN cord-015306-us58wwmp 1982 21 edema edema NN cord-015306-us58wwmp 1982 22 , , , cord-015306-us58wwmp 1982 23 gross gross JJ cord-015306-us58wwmp 1982 24 proteinuria proteinuria NN cord-015306-us58wwmp 1982 25 , , , cord-015306-us58wwmp 1982 26 and and CC cord-015306-us58wwmp 1982 27 progressive progressive JJ cord-015306-us58wwmp 1982 28 renal renal JJ cord-015306-us58wwmp 1982 29 failure failure NN cord-015306-us58wwmp 1982 30 . . . cord-015306-us58wwmp 1983 1 She -PRON- PRP cord-015306-us58wwmp 1983 2 was be VBD cord-015306-us58wwmp 1983 3 delivered deliver VBN cord-015306-us58wwmp 1983 4 spontaneously spontaneously RB cord-015306-us58wwmp 1983 5 at at IN cord-015306-us58wwmp 1983 6 36 36 CD cord-015306-us58wwmp 1983 7 weeks week NNS cord-015306-us58wwmp 1983 8 of of IN cord-015306-us58wwmp 1983 9 gestation gestation NN cord-015306-us58wwmp 1983 10 with with IN cord-015306-us58wwmp 1983 11 a a DT cord-015306-us58wwmp 1983 12 birth birth NN cord-015306-us58wwmp 1983 13 weight weight NN cord-015306-us58wwmp 1983 14 of of IN cord-015306-us58wwmp 1983 15 2700gand 2700gand CD cord-015306-us58wwmp 1983 16 a a DT cord-015306-us58wwmp 1983 17 body body NN cord-015306-us58wwmp 1983 18 length length NN cord-015306-us58wwmp 1983 19 of48 of48 NNP cord-015306-us58wwmp 1983 20 cm cm NN cord-015306-us58wwmp 1983 21 . . . cord-015306-us58wwmp 1984 1 During during IN cord-015306-us58wwmp 1984 2 the the DT cord-015306-us58wwmp 1984 3 delivery delivery NN cord-015306-us58wwmp 1984 4 , , , cord-015306-us58wwmp 1984 5 she -PRON- PRP cord-015306-us58wwmp 1984 6 was be VBD cord-015306-us58wwmp 1984 7 experienced experience VBN cord-015306-us58wwmp 1984 8 mild mild JJ cord-015306-us58wwmp 1984 9 asphyxia asphyxia NN cord-015306-us58wwmp 1984 10 . . . cord-015306-us58wwmp 1985 1 Placental placental JJ cord-015306-us58wwmp 1985 2 weight weight NN cord-015306-us58wwmp 1985 3 was be VBD cord-015306-us58wwmp 1985 4 large large JJ cord-015306-us58wwmp 1985 5 , , , cord-015306-us58wwmp 1985 6 and and CC cord-015306-us58wwmp 1985 7 the the DT cord-015306-us58wwmp 1985 8 amniotic amniotic NN cord-015306-us58wwmp 1985 9 fluid fluid NN cord-015306-us58wwmp 1985 10 was be VBD cord-015306-us58wwmp 1985 11 meconium meconium NN cord-015306-us58wwmp 1985 12 - - HYPH cord-015306-us58wwmp 1985 13 stained stain VBN cord-015306-us58wwmp 1985 14 . . . cord-015306-us58wwmp 1986 1 Pregnancy pregnancy NN cord-015306-us58wwmp 1986 2 was be VBD cord-015306-us58wwmp 1986 3 unremarkable unremarkable JJ cord-015306-us58wwmp 1986 4 and and CC cord-015306-us58wwmp 1986 5 had have VBD cord-015306-us58wwmp 1986 6 included include VBN cord-015306-us58wwmp 1986 7 routine routine JJ cord-015306-us58wwmp 1986 8 prenatal prenatal JJ cord-015306-us58wwmp 1986 9 ultrasound ultrasound NN cord-015306-us58wwmp 1986 10 evaluation evaluation NN cord-015306-us58wwmp 1986 11 . . . cord-015306-us58wwmp 1987 1 The the DT cord-015306-us58wwmp 1987 2 family family NN cord-015306-us58wwmp 1987 3 history history NN cord-015306-us58wwmp 1987 4 of of IN cord-015306-us58wwmp 1987 5 proteinuria proteinuria NN cord-015306-us58wwmp 1987 6 or or CC cord-015306-us58wwmp 1987 7 renal renal JJ cord-015306-us58wwmp 1987 8 failure failure NN cord-015306-us58wwmp 1987 9 was be VBD cord-015306-us58wwmp 1987 10 negative negative JJ cord-015306-us58wwmp 1987 11 . . . cord-015306-us58wwmp 1988 1 On on IN cord-015306-us58wwmp 1988 2 admission admission NN cord-015306-us58wwmp 1988 3 , , , cord-015306-us58wwmp 1988 4 the the DT cord-015306-us58wwmp 1988 5 findings finding NNS cord-015306-us58wwmp 1988 6 from from IN cord-015306-us58wwmp 1988 7 physical physical JJ cord-015306-us58wwmp 1988 8 examination examination NN cord-015306-us58wwmp 1988 9 showed show VBD cord-015306-us58wwmp 1988 10 the the DT cord-015306-us58wwmp 1988 11 patient patient NN cord-015306-us58wwmp 1988 12 had have VBD cord-015306-us58wwmp 1988 13 bilateral bilateral JJ cord-015306-us58wwmp 1988 14 microcoria microcoria NN cord-015306-us58wwmp 1988 15 and and CC cord-015306-us58wwmp 1988 16 Limb limb NN cord-015306-us58wwmp 1988 17 hypotonia hypotonia NNS cord-015306-us58wwmp 1988 18 . . . cord-015306-us58wwmp 1989 1 Results result NNS cord-015306-us58wwmp 1989 2 of of IN cord-015306-us58wwmp 1989 3 serological serological JJ cord-015306-us58wwmp 1989 4 testing testing NN cord-015306-us58wwmp 1989 5 for for IN cord-015306-us58wwmp 1989 6 TORCH torch NN cord-015306-us58wwmp 1989 7 infections infection NNS cord-015306-us58wwmp 1989 8 were be VBD cord-015306-us58wwmp 1989 9 negative negative JJ cord-015306-us58wwmp 1989 10 . . . cord-015306-us58wwmp 1990 1 Since since IN cord-015306-us58wwmp 1990 2 Pierson Pierson NNP cord-015306-us58wwmp 1990 3 syndrome syndrome NN cord-015306-us58wwmp 1990 4 was be VBD cord-015306-us58wwmp 1990 5 suspected suspect VBN cord-015306-us58wwmp 1990 6 , , , cord-015306-us58wwmp 1990 7 a a DT cord-015306-us58wwmp 1990 8 kidney kidney NN cord-015306-us58wwmp 1990 9 biopsy biopsy NN cord-015306-us58wwmp 1990 10 was be VBD cord-015306-us58wwmp 1990 11 performed perform VBN cord-015306-us58wwmp 1990 12 when when WRB cord-015306-us58wwmp 1990 13 she -PRON- PRP cord-015306-us58wwmp 1990 14 was be VBD cord-015306-us58wwmp 1990 15 aged age VBN cord-015306-us58wwmp 1990 16 10 10 CD cord-015306-us58wwmp 1990 17 days day NNS cord-015306-us58wwmp 1990 18 . . . cord-015306-us58wwmp 1991 1 Meanwhile meanwhile RB cord-015306-us58wwmp 1991 2 , , , cord-015306-us58wwmp 1991 3 all all DT cord-015306-us58wwmp 1991 4 coding code VBG cord-015306-us58wwmp 1991 5 exons exon NNS cord-015306-us58wwmp 1991 6 of of IN cord-015306-us58wwmp 1991 7 LAMB2 LAMB2 NNP cord-015306-us58wwmp 1991 8 were be VBD cord-015306-us58wwmp 1991 9 analyzed analyze VBN cord-015306-us58wwmp 1991 10 by by IN cord-015306-us58wwmp 1991 11 using use VBG cord-015306-us58wwmp 1991 12 PCR PCR NNP cord-015306-us58wwmp 1991 13 and and CC cord-015306-us58wwmp 1991 14 direct direct JJ cord-015306-us58wwmp 1991 15 sequencing sequencing NN cord-015306-us58wwmp 1991 16 . . . cord-015306-us58wwmp 1992 1 Results result NNS cord-015306-us58wwmp 1992 2 : : : cord-015306-us58wwmp 1993 1 Electron electron NN cord-015306-us58wwmp 1993 2 microscopy microscopy NN cord-015306-us58wwmp 1993 3 revealed reveal VBD cord-015306-us58wwmp 1993 4 some some DT cord-015306-us58wwmp 1993 5 glomerular glomerular JJ cord-015306-us58wwmp 1993 6 basement basement NN cord-015306-us58wwmp 1993 7 membranes membrane NNS cord-015306-us58wwmp 1993 8 were be VBD cord-015306-us58wwmp 1993 9 thick thick JJ cord-015306-us58wwmp 1993 10 and and CC cord-015306-us58wwmp 1993 11 thinning thin VBG cord-015306-us58wwmp 1993 12 , , , cord-015306-us58wwmp 1993 13 with with IN cord-015306-us58wwmp 1993 14 splitting splitting NN cord-015306-us58wwmp 1993 15 of of IN cord-015306-us58wwmp 1993 16 the the DT cord-015306-us58wwmp 1993 17 lamina lamina NNP cord-015306-us58wwmp 1993 18 densa densa NNP cord-015306-us58wwmp 1993 19 . . . cord-015306-us58wwmp 1994 1 In in IN cord-015306-us58wwmp 1994 2 addition addition NN cord-015306-us58wwmp 1994 3 , , , cord-015306-us58wwmp 1994 4 the the DT cord-015306-us58wwmp 1994 5 foot foot NN cord-015306-us58wwmp 1994 6 processes process NNS cord-015306-us58wwmp 1994 7 of of IN cord-015306-us58wwmp 1994 8 podocytes podocyte NNS cord-015306-us58wwmp 1994 9 were be VBD cord-015306-us58wwmp 1994 10 diffusely diffusely RB cord-015306-us58wwmp 1994 11 effaced efface VBN cord-015306-us58wwmp 1994 12 , , , cord-015306-us58wwmp 1994 13 and and CC cord-015306-us58wwmp 1994 14 the the DT cord-015306-us58wwmp 1994 15 number number NN cord-015306-us58wwmp 1994 16 of of IN cord-015306-us58wwmp 1994 17 podocytes podocyte NNS cord-015306-us58wwmp 1994 18 increased increase VBD cord-015306-us58wwmp 1994 19 . . . cord-015306-us58wwmp 1995 1 Two two CD cord-015306-us58wwmp 1995 2 different different JJ cord-015306-us58wwmp 1995 3 novel novel NN cord-015306-us58wwmp 1995 4 nonsense nonsense NN cord-015306-us58wwmp 1995 5 mutations mutation NNS cord-015306-us58wwmp 1995 6 ( ( -LRB- cord-015306-us58wwmp 1995 7 Trp16X trp16x NN cord-015306-us58wwmp 1995 8 and and CC cord-015306-us58wwmp 1995 9 Gln748X Gln748X NNP cord-015306-us58wwmp 1995 10 ) ) -RRB- cord-015306-us58wwmp 1995 11 of of IN cord-015306-us58wwmp 1995 12 LAMB2 LAMB2 NNP cord-015306-us58wwmp 1995 13 were be VBD cord-015306-us58wwmp 1995 14 detected detect VBN cord-015306-us58wwmp 1995 15 in in IN cord-015306-us58wwmp 1995 16 the the DT cord-015306-us58wwmp 1995 17 patient patient NN cord-015306-us58wwmp 1995 18 . . . cord-015306-us58wwmp 1996 1 These these DT cord-015306-us58wwmp 1996 2 mutations mutation NNS cord-015306-us58wwmp 1996 3 were be VBD cord-015306-us58wwmp 1996 4 inherited inherit VBN cord-015306-us58wwmp 1996 5 from from IN cord-015306-us58wwmp 1996 6 her -PRON- PRP$ cord-015306-us58wwmp 1996 7 parents parent NNS cord-015306-us58wwmp 1996 8 respectively respectively RB cord-015306-us58wwmp 1996 9 . . . cord-015306-us58wwmp 1997 1 Conclusions conclusion NNS cord-015306-us58wwmp 1997 2 : : : cord-015306-us58wwmp 1998 1 Newborn newborn JJ cord-015306-us58wwmp 1998 2 with with IN cord-015306-us58wwmp 1998 3 unexplained unexplained JJ cord-015306-us58wwmp 1998 4 renal renal JJ cord-015306-us58wwmp 1998 5 insufficiency insufficiency NN cord-015306-us58wwmp 1998 6 or or CC cord-015306-us58wwmp 1998 7 nephrotic nephrotic JJ cord-015306-us58wwmp 1998 8 syndrome syndrome NN cord-015306-us58wwmp 1998 9 should should MD cord-015306-us58wwmp 1998 10 consider consider VB cord-015306-us58wwmp 1998 11 Pierson Pierson NNP cord-015306-us58wwmp 1998 12 syndrome syndrome NN cord-015306-us58wwmp 1998 13 . . . cord-015306-us58wwmp 1999 1 Our -PRON- PRP$ cord-015306-us58wwmp 1999 2 report report NN cord-015306-us58wwmp 1999 3 extends extend VBZ cord-015306-us58wwmp 1999 4 the the DT cord-015306-us58wwmp 1999 5 genotypic genotypic JJ cord-015306-us58wwmp 1999 6 spectrum spectrum NN cord-015306-us58wwmp 1999 7 of of IN cord-015306-us58wwmp 1999 8 Pierson Pierson NNP cord-015306-us58wwmp 1999 9 syndrome syndrome NN cord-015306-us58wwmp 1999 10 . . . cord-015306-us58wwmp 2000 1 A a DT cord-015306-us58wwmp 2000 2 familial familial JJ cord-015306-us58wwmp 2000 3 WT1 WT1 NNP cord-015306-us58wwmp 2000 4 mutation mutation NN cord-015306-us58wwmp 2000 5 associated associate VBN cord-015306-us58wwmp 2000 6 with with IN cord-015306-us58wwmp 2000 7 incomplete incomplete JJ cord-015306-us58wwmp 2000 8 Denys Denys NNP cord-015306-us58wwmp 2000 9 - - HYPH cord-015306-us58wwmp 2000 10 Drash Drash NNP cord-015306-us58wwmp 2000 11 syndrome syndrome NN cord-015306-us58wwmp 2000 12 We -PRON- PRP cord-015306-us58wwmp 2000 13 report report VBP cord-015306-us58wwmp 2000 14 a a DT cord-015306-us58wwmp 2000 15 familial familial NN cord-015306-us58wwmp 2000 16 WT1 wt1 NN cord-015306-us58wwmp 2000 17 missense missense JJ cord-015306-us58wwmp 2000 18 mutation mutation NN cord-015306-us58wwmp 2000 19 in in IN cord-015306-us58wwmp 2000 20 exon exon NN cord-015306-us58wwmp 2000 21 9 9 CD cord-015306-us58wwmp 2000 22 ( ( -LRB- cord-015306-us58wwmp 2000 23 1180C 1180C NNP cord-015306-us58wwmp 2001 1 > > XX cord-015306-us58wwmp 2002 1 T T NNP cord-015306-us58wwmp 2002 2 , , , cord-015306-us58wwmp 2002 3 R394W R394W NNP cord-015306-us58wwmp 2002 4 ) ) -RRB- cord-015306-us58wwmp 2002 5 in in IN cord-015306-us58wwmp 2002 6 three three CD cord-015306-us58wwmp 2002 7 members member NNS cord-015306-us58wwmp 2002 8 of of IN cord-015306-us58wwmp 2002 9 one one CD cord-015306-us58wwmp 2002 10 family family NN cord-015306-us58wwmp 2002 11 . . . cord-015306-us58wwmp 2003 1 Patient Patient NNP cord-015306-us58wwmp 2003 2 1 1 CD cord-015306-us58wwmp 2003 3 , , , cord-015306-us58wwmp 2003 4 a a DT cord-015306-us58wwmp 2003 5 2 2 CD cord-015306-us58wwmp 2003 6 years year NNS cord-015306-us58wwmp 2003 7 old old JJ cord-015306-us58wwmp 2003 8 boy boy NN cord-015306-us58wwmp 2003 9 , , , cord-015306-us58wwmp 2003 10 was be VBD cord-015306-us58wwmp 2003 11 born bear VBN cord-015306-us58wwmp 2003 12 at at IN cord-015306-us58wwmp 2003 13 ambiguous ambiguous JJ cord-015306-us58wwmp 2003 14 genitalia genitalia NNS cord-015306-us58wwmp 2003 15 ( ( -LRB- cord-015306-us58wwmp 2003 16 46 46 CD cord-015306-us58wwmp 2003 17 , , , cord-015306-us58wwmp 2003 18 XY XY NNP cord-015306-us58wwmp 2003 19 karyotype karyotype NNP cord-015306-us58wwmp 2003 20 ) ) -RRB- cord-015306-us58wwmp 2003 21 , , , cord-015306-us58wwmp 2003 22 penoscrotal penoscrotal JJ cord-015306-us58wwmp 2003 23 hypospadias hypospadia NNS cord-015306-us58wwmp 2003 24 and and CC cord-015306-us58wwmp 2003 25 bilateral bilateral JJ cord-015306-us58wwmp 2003 26 inguinal inguinal JJ cord-015306-us58wwmp 2003 27 hernias hernia NNS cord-015306-us58wwmp 2003 28 . . . cord-015306-us58wwmp 2004 1 He -PRON- PRP cord-015306-us58wwmp 2004 2 was be VBD cord-015306-us58wwmp 2004 3 found find VBN cord-015306-us58wwmp 2004 4 proteinuria proteinuria NN cord-015306-us58wwmp 2004 5 on on IN cord-015306-us58wwmp 2004 6 the the DT cord-015306-us58wwmp 2004 7 preoperative preoperative JJ cord-015306-us58wwmp 2004 8 examination examination NN cord-015306-us58wwmp 2004 9 and and CC cord-015306-us58wwmp 2004 10 renal renal JJ cord-015306-us58wwmp 2004 11 biopsy biopsy NN cord-015306-us58wwmp 2004 12 showed show VBD cord-015306-us58wwmp 2004 13 diffuse diffuse JJ cord-015306-us58wwmp 2004 14 mesangial mesangial JJ cord-015306-us58wwmp 2004 15 sclerosis sclerosis NN cord-015306-us58wwmp 2004 16 . . . cord-015306-us58wwmp 2005 1 Patient Patient NNP cord-015306-us58wwmp 2005 2 2 2 CD cord-015306-us58wwmp 2005 3 , , , cord-015306-us58wwmp 2005 4 a a DT cord-015306-us58wwmp 2005 5 3 3 CD cord-015306-us58wwmp 2005 6 years year NNS cord-015306-us58wwmp 2005 7 old old JJ cord-015306-us58wwmp 2005 8 , , , cord-015306-us58wwmp 2005 9 is be VBZ cord-015306-us58wwmp 2005 10 the the DT cord-015306-us58wwmp 2005 11 older old JJR cord-015306-us58wwmp 2005 12 sister sister NN cord-015306-us58wwmp 2005 13 of of IN cord-015306-us58wwmp 2005 14 Patient Patient NNP cord-015306-us58wwmp 2005 15 1 1 CD cord-015306-us58wwmp 2005 16 , , , cord-015306-us58wwmp 2005 17 who who WP cord-015306-us58wwmp 2005 18 has have VBZ cord-015306-us58wwmp 2005 19 normal normal JJ cord-015306-us58wwmp 2005 20 genitalia genitalia NNS cord-015306-us58wwmp 2005 21 . . . cord-015306-us58wwmp 2006 1 She -PRON- PRP cord-015306-us58wwmp 2006 2 was be VBD cord-015306-us58wwmp 2006 3 found find VBN cord-015306-us58wwmp 2006 4 proteinuria proteinuria NN cord-015306-us58wwmp 2006 5 and and CC cord-015306-us58wwmp 2006 6 renal renal JJ cord-015306-us58wwmp 2006 7 biopsy biopsy NN cord-015306-us58wwmp 2006 8 showed show VBD cord-015306-us58wwmp 2006 9 focal focal JJ cord-015306-us58wwmp 2006 10 mesangial mesangial JJ cord-015306-us58wwmp 2006 11 sclerosis sclerosis NN cord-015306-us58wwmp 2006 12 . . . cord-015306-us58wwmp 2007 1 Wilms Wilms NNP cord-015306-us58wwmp 2007 2 's 's POS cord-015306-us58wwmp 2007 3 tumor tumor NN cord-015306-us58wwmp 2007 4 was be VBD cord-015306-us58wwmp 2007 5 not not RB cord-015306-us58wwmp 2007 6 found find VBN cord-015306-us58wwmp 2007 7 in in IN cord-015306-us58wwmp 2007 8 both both DT cord-015306-us58wwmp 2007 9 of of IN cord-015306-us58wwmp 2007 10 them -PRON- PRP cord-015306-us58wwmp 2007 11 . . . cord-015306-us58wwmp 2008 1 A a DT cord-015306-us58wwmp 2008 2 WT1 WT1 NNP cord-015306-us58wwmp 2008 3 mutation mutation NN cord-015306-us58wwmp 2008 4 was be VBD cord-015306-us58wwmp 2008 5 detected detect VBN cord-015306-us58wwmp 2008 6 in in IN cord-015306-us58wwmp 2008 7 both both CC cord-015306-us58wwmp 2008 8 the the DT cord-015306-us58wwmp 2008 9 two two CD cord-015306-us58wwmp 2008 10 patients patient NNS cord-015306-us58wwmp 2008 11 and and CC cord-015306-us58wwmp 2008 12 their -PRON- PRP$ cord-015306-us58wwmp 2008 13 farther far RBR cord-015306-us58wwmp 2008 14 . . . cord-015306-us58wwmp 2009 1 The the DT cord-015306-us58wwmp 2009 2 patients patient NNS cord-015306-us58wwmp 2009 3 are be VBP cord-015306-us58wwmp 2009 4 considered consider VBN cord-015306-us58wwmp 2009 5 as as RB cord-015306-us58wwmp 2009 6 incomplete incomplete JJ cord-015306-us58wwmp 2009 7 DDS DDS NNP cord-015306-us58wwmp 2009 8 and and CC cord-015306-us58wwmp 2009 9 they -PRON- PRP cord-015306-us58wwmp 2009 10 can can MD cord-015306-us58wwmp 2009 11 inherit inherit VB cord-015306-us58wwmp 2009 12 mutations mutation NNS cord-015306-us58wwmp 2009 13 from from IN cord-015306-us58wwmp 2009 14 their -PRON- PRP$ cord-015306-us58wwmp 2009 15 father father NN cord-015306-us58wwmp 2009 16 . . . cord-015306-us58wwmp 2010 1 So so RB cord-015306-us58wwmp 2010 2 , , , cord-015306-us58wwmp 2010 3 this this DT cord-015306-us58wwmp 2010 4 finding finding NN cord-015306-us58wwmp 2010 5 will will MD cord-015306-us58wwmp 2010 6 provide provide VB cord-015306-us58wwmp 2010 7 new new JJ cord-015306-us58wwmp 2010 8 evidence evidence NN cord-015306-us58wwmp 2010 9 for for IN cord-015306-us58wwmp 2010 10 a a DT cord-015306-us58wwmp 2010 11 better well JJR cord-015306-us58wwmp 2010 12 understanding understanding NN cord-015306-us58wwmp 2010 13 of of IN cord-015306-us58wwmp 2010 14 DDS DDS NNP cord-015306-us58wwmp 2010 15 and and CC cord-015306-us58wwmp 2010 16 further further JJ cord-015306-us58wwmp 2010 17 familial familial JJ cord-015306-us58wwmp 2010 18 studies study NNS cord-015306-us58wwmp 2010 19 in in IN cord-015306-us58wwmp 2010 20 patients patient NNS cord-015306-us58wwmp 2010 21 of of IN cord-015306-us58wwmp 2010 22 DDS DDS NNP cord-015306-us58wwmp 2010 23 are be VBP cord-015306-us58wwmp 2010 24 need nee VBN cord-015306-us58wwmp 2010 25 . . . cord-015306-us58wwmp 2011 1 Ying Ying NNP cord-015306-us58wwmp 2011 2 Chen Chen NNP cord-015306-us58wwmp 2011 3 1 1 CD cord-015306-us58wwmp 2011 4 , , , cord-015306-us58wwmp 2011 5 Songming Songming NNP cord-015306-us58wwmp 2011 6 Huang Huang NNP cord-015306-us58wwmp 2011 7 1 1 CD cord-015306-us58wwmp 2011 8 , , , cord-015306-us58wwmp 2011 9 2 2 CD cord-015306-us58wwmp 2011 10 , , , cord-015306-us58wwmp 2011 11 Guixia Guixia NNP cord-015306-us58wwmp 2011 12 Ding Ding NNP cord-015306-us58wwmp 2011 13 1 1 CD cord-015306-us58wwmp 2011 14 , , , cord-015306-us58wwmp 2011 15 2 2 CD cord-015306-us58wwmp 2011 16 , , , cord-015306-us58wwmp 2011 17 Hongmei Hongmei NNP cord-015306-us58wwmp 2011 18 Wu Wu NNP cord-015306-us58wwmp 2011 19 1 1 CD cord-015306-us58wwmp 2011 20 , , , cord-015306-us58wwmp 2011 21 Aihua Aihua NNP cord-015306-us58wwmp 2011 22 Zhang Zhang NNP cord-015306-us58wwmp 2011 23 1 1 CD cord-015306-us58wwmp 2011 24 , , , cord-015306-us58wwmp 2012 1 2 2 CD cord-015306-us58wwmp 2012 2 1 1 CD cord-015306-us58wwmp 2012 3 Nephrology Nephrology NNP cord-015306-us58wwmp 2012 4 , , , cord-015306-us58wwmp 2012 5 Nanjing Nanjing NNP cord-015306-us58wwmp 2012 6 Children Children NNPS cord-015306-us58wwmp 2012 7 's 's POS cord-015306-us58wwmp 2012 8 Hospital Hospital NNP cord-015306-us58wwmp 2012 9 , , , cord-015306-us58wwmp 2012 10 Nanjing Nanjing NNP cord-015306-us58wwmp 2012 11 , , , cord-015306-us58wwmp 2012 12 China China NNP cord-015306-us58wwmp 2012 13 2 2 CD cord-015306-us58wwmp 2012 14 Institute Institute NNP cord-015306-us58wwmp 2012 15 of of IN cord-015306-us58wwmp 2012 16 Pediatrics Pediatrics NNP cord-015306-us58wwmp 2012 17 , , , cord-015306-us58wwmp 2012 18 Nanjing Nanjing NNP cord-015306-us58wwmp 2012 19 Medical Medical NNP cord-015306-us58wwmp 2012 20 University University NNP cord-015306-us58wwmp 2012 21 , , , cord-015306-us58wwmp 2012 22 Nanjing Nanjing NNP cord-015306-us58wwmp 2012 23 , , , cord-015306-us58wwmp 2013 1 China China NNP cord-015306-us58wwmp 2013 2 Objective Objective NNP cord-015306-us58wwmp 2013 3 : : : cord-015306-us58wwmp 2013 4 To to TO cord-015306-us58wwmp 2013 5 investigate investigate VB cord-015306-us58wwmp 2013 6 the the DT cord-015306-us58wwmp 2013 7 correlations correlation NNS cord-015306-us58wwmp 2013 8 between between IN cord-015306-us58wwmp 2013 9 Peroxisome Peroxisome NNP cord-015306-us58wwmp 2013 10 proliferator proliferator NN cord-015306-us58wwmp 2013 11 - - HYPH cord-015306-us58wwmp 2013 12 activated activate VBN cord-015306-us58wwmp 2013 13 receptor receptor NN cord-015306-us58wwmp 2013 14 ( ( -LRB- cord-015306-us58wwmp 2013 15 PPAR)-α PPAR)-α NNP cord-015306-us58wwmp 2013 16 , , , cord-015306-us58wwmp 2013 17 PPAR PPAR NNP cord-015306-us58wwmp 2013 18 - - HYPH cord-015306-us58wwmp 2013 19 γ γ NNP cord-015306-us58wwmp 2013 20 , , , cord-015306-us58wwmp 2013 21 and and CC cord-015306-us58wwmp 2013 22 PPAR PPAR NNP cord-015306-us58wwmp 2013 23 - - HYPH cord-015306-us58wwmp 2013 24 γ γ NN cord-015306-us58wwmp 2013 25 coactivator-1α coactivator-1α NNP cord-015306-us58wwmp 2013 26 ( ( -LRB- cord-015306-us58wwmp 2013 27 PGC-1α pgc-1α NN cord-015306-us58wwmp 2013 28 ) ) -RRB- cord-015306-us58wwmp 2013 29 gene gene NN cord-015306-us58wwmp 2013 30 polymorphisms polymorphism NNS cord-015306-us58wwmp 2013 31 and and CC cord-015306-us58wwmp 2013 32 susceptibility susceptibility NN cord-015306-us58wwmp 2013 33 to to IN cord-015306-us58wwmp 2013 34 primary primary JJ cord-015306-us58wwmp 2013 35 nephrotic nephrotic JJ cord-015306-us58wwmp 2013 36 syndrome syndrome NN cord-015306-us58wwmp 2013 37 ( ( -LRB- cord-015306-us58wwmp 2013 38 PNS PNS NNP cord-015306-us58wwmp 2013 39 ) ) -RRB- cord-015306-us58wwmp 2013 40 . . . cord-015306-us58wwmp 2014 1 Methods method NNS cord-015306-us58wwmp 2014 2 : : : cord-015306-us58wwmp 2014 3 Patient patient NN cord-015306-us58wwmp 2014 4 genotypes genotype NNS cord-015306-us58wwmp 2014 5 were be VBD cord-015306-us58wwmp 2014 6 determined determine VBN cord-015306-us58wwmp 2014 7 using use VBG cord-015306-us58wwmp 2014 8 the the DT cord-015306-us58wwmp 2014 9 polymerase polymerase NN cord-015306-us58wwmp 2014 10 chain chain NN cord-015306-us58wwmp 2014 11 reaction reaction NN cord-015306-us58wwmp 2014 12 - - HYPH cord-015306-us58wwmp 2014 13 restriction restriction NN cord-015306-us58wwmp 2014 14 fragment fragment NN cord-015306-us58wwmp 2014 15 length length NN cord-015306-us58wwmp 2014 16 polymorphism polymorphism NN cord-015306-us58wwmp 2014 17 ( ( -LRB- cord-015306-us58wwmp 2014 18 PCR PCR NNP cord-015306-us58wwmp 2014 19 - - HYPH cord-015306-us58wwmp 2014 20 RFLP RFLP NNP cord-015306-us58wwmp 2014 21 ) ) -RRB- cord-015306-us58wwmp 2014 22 technique technique NN cord-015306-us58wwmp 2014 23 for for IN cord-015306-us58wwmp 2014 24 the the DT cord-015306-us58wwmp 2014 25 Pro12AlA Pro12AlA NNP cord-015306-us58wwmp 2014 26 and and CC cord-015306-us58wwmp 2014 27 Val290Met val290met CD cord-015306-us58wwmp 2014 28 polymorphisms polymorphism NNS cord-015306-us58wwmp 2014 29 of of IN cord-015306-us58wwmp 2014 30 the the DT cord-015306-us58wwmp 2014 31 PPAR PPAR NNP cord-015306-us58wwmp 2014 32 - - HYPH cord-015306-us58wwmp 2014 33 γ γ NN cord-015306-us58wwmp 2014 34 gene gene NN cord-015306-us58wwmp 2014 35 , , , cord-015306-us58wwmp 2014 36 the the DT cord-015306-us58wwmp 2014 37 Gly482Ser gly482ser JJ cord-015306-us58wwmp 2014 38 polymorphism polymorphism NN cord-015306-us58wwmp 2014 39 of of IN cord-015306-us58wwmp 2014 40 the the DT cord-015306-us58wwmp 2014 41 PGC-1α PGC-1α NNP cord-015306-us58wwmp 2014 42 gene gene NN cord-015306-us58wwmp 2014 43 , , , cord-015306-us58wwmp 2014 44 and and CC cord-015306-us58wwmp 2014 45 the the DT cord-015306-us58wwmp 2014 46 Leu62Val Leu62Val NNP cord-015306-us58wwmp 2014 47 polymorphism polymorphism NN cord-015306-us58wwmp 2014 48 of of IN cord-015306-us58wwmp 2014 49 the the DT cord-015306-us58wwmp 2014 50 PPAR PPAR NNP cord-015306-us58wwmp 2014 51 - - HYPH cord-015306-us58wwmp 2014 52 α α NN cord-015306-us58wwmp 2014 53 gene gene NN cord-015306-us58wwmp 2014 54 . . . cord-015306-us58wwmp 2015 1 The the DT cord-015306-us58wwmp 2015 2 gene gene NN cord-015306-us58wwmp 2015 3 polymorphisms polymorphism NNS cord-015306-us58wwmp 2015 4 in in IN cord-015306-us58wwmp 2015 5 111 111 CD cord-015306-us58wwmp 2015 6 cases case NNS cord-015306-us58wwmp 2015 7 of of IN cord-015306-us58wwmp 2015 8 PNS PNS NNP cord-015306-us58wwmp 2015 9 in in IN cord-015306-us58wwmp 2015 10 children child NNS cord-015306-us58wwmp 2015 11 and and CC cord-015306-us58wwmp 2015 12 111 111 CD cord-015306-us58wwmp 2015 13 normal normal JJ cord-015306-us58wwmp 2015 14 controls control NNS cord-015306-us58wwmp 2015 15 ( ( -LRB- cord-015306-us58wwmp 2015 16 NC NC NNP cord-015306-us58wwmp 2015 17 ) ) -RRB- cord-015306-us58wwmp 2015 18 were be VBD cord-015306-us58wwmp 2015 19 analyzed analyze VBN cord-015306-us58wwmp 2015 20 and and CC cord-015306-us58wwmp 2015 21 compared compare VBN cord-015306-us58wwmp 2015 22 to to TO cord-015306-us58wwmp 2015 23 examine examine VB cord-015306-us58wwmp 2015 24 the the DT cord-015306-us58wwmp 2015 25 differences difference NNS cord-015306-us58wwmp 2015 26 in in IN cord-015306-us58wwmp 2015 27 the the DT cord-015306-us58wwmp 2015 28 clinical clinical JJ cord-015306-us58wwmp 2015 29 metabolism metabolism NN cord-015306-us58wwmp 2015 30 index index NN cord-015306-us58wwmp 2015 31 , , , cord-015306-us58wwmp 2015 32 proteinuria proteinuria NN cord-015306-us58wwmp 2015 33 , , , cord-015306-us58wwmp 2015 34 renal renal JJ cord-015306-us58wwmp 2015 35 pathological pathological JJ cord-015306-us58wwmp 2015 36 types type NNS cord-015306-us58wwmp 2015 37 , , , cord-015306-us58wwmp 2015 38 and and CC cord-015306-us58wwmp 2015 39 hormone hormone NN cord-015306-us58wwmp 2015 40 treatment treatment NN cord-015306-us58wwmp 2015 41 responses response NNS cord-015306-us58wwmp 2015 42 among among IN cord-015306-us58wwmp 2015 43 PNS PNS NNP cord-015306-us58wwmp 2015 44 children child NNS cord-015306-us58wwmp 2015 45 with with IN cord-015306-us58wwmp 2015 46 different different JJ cord-015306-us58wwmp 2015 47 genotypes genotype NNS cord-015306-us58wwmp 2015 48 . . . cord-015306-us58wwmp 2016 1 Results result NNS cord-015306-us58wwmp 2016 2 : : : cord-015306-us58wwmp 2017 1 The the DT cord-015306-us58wwmp 2017 2 PPAR PPAR NNP cord-015306-us58wwmp 2017 3 - - HYPH cord-015306-us58wwmp 2017 4 γ γ NN cord-015306-us58wwmp 2017 5 Pro12Ala Pro12Ala NNS cord-015306-us58wwmp 2017 6 and and CC cord-015306-us58wwmp 2018 1 PGC-1α PGC-1α NNP cord-015306-us58wwmp 2018 2 Gly482Ser gly482ser JJ cord-015306-us58wwmp 2018 3 mutations mutation NNS cord-015306-us58wwmp 2018 4 were be VBD cord-015306-us58wwmp 2018 5 not not RB cord-015306-us58wwmp 2018 6 associated associate VBN cord-015306-us58wwmp 2018 7 with with IN cord-015306-us58wwmp 2018 8 the the DT cord-015306-us58wwmp 2018 9 occurrence occurrence NN cord-015306-us58wwmp 2018 10 , , , cord-015306-us58wwmp 2018 11 blood blood NN cord-015306-us58wwmp 2018 12 pressure pressure NN cord-015306-us58wwmp 2018 13 , , , cord-015306-us58wwmp 2018 14 total total JJ cord-015306-us58wwmp 2018 15 cholesterol cholesterol NN cord-015306-us58wwmp 2018 16 , , , cord-015306-us58wwmp 2018 17 a a DT cord-015306-us58wwmp 2018 18 decrease decrease NN cord-015306-us58wwmp 2018 19 in in IN cord-015306-us58wwmp 2018 20 glomerular glomerular JJ cord-015306-us58wwmp 2018 21 filtration filtration NN cord-015306-us58wwmp 2018 22 rate rate NN cord-015306-us58wwmp 2018 23 ( ( -LRB- cord-015306-us58wwmp 2018 24 GFR GFR NNP cord-015306-us58wwmp 2018 25 ) ) -RRB- cord-015306-us58wwmp 2018 26 , , , cord-015306-us58wwmp 2018 27 urine urine NN cord-015306-us58wwmp 2018 28 protein protein NN cord-015306-us58wwmp 2018 29 excretion excretion NN cord-015306-us58wwmp 2018 30 at at IN cord-015306-us58wwmp 2018 31 the the DT cord-015306-us58wwmp 2018 32 onset onset NN cord-015306-us58wwmp 2018 33 of of IN cord-015306-us58wwmp 2018 34 disease disease NN cord-015306-us58wwmp 2018 35 , , , cord-015306-us58wwmp 2018 36 renal renal JJ cord-015306-us58wwmp 2018 37 pathological pathological JJ cord-015306-us58wwmp 2018 38 type type NN cord-015306-us58wwmp 2018 39 , , , cord-015306-us58wwmp 2018 40 or or CC cord-015306-us58wwmp 2018 41 hormone hormone NN cord-015306-us58wwmp 2018 42 treatment treatment NN cord-015306-us58wwmp 2018 43 response response NN cord-015306-us58wwmp 2018 44 in in IN cord-015306-us58wwmp 2018 45 children child NNS cord-015306-us58wwmp 2018 46 with with IN cord-015306-us58wwmp 2018 47 PNS PNS NNP cord-015306-us58wwmp 2018 48 . . . cord-015306-us58wwmp 2019 1 Although although IN cord-015306-us58wwmp 2019 2 the the DT cord-015306-us58wwmp 2019 3 Homa Homa NNP cord-015306-us58wwmp 2019 4 - - HYPH cord-015306-us58wwmp 2019 5 IR IR NNP cord-015306-us58wwmp 2019 6 values value NNS cord-015306-us58wwmp 2019 7 for for IN cord-015306-us58wwmp 2019 8 children child NNS cord-015306-us58wwmp 2019 9 with with IN cord-015306-us58wwmp 2019 10 the the DT cord-015306-us58wwmp 2019 11 A a DT cord-015306-us58wwmp 2019 12 allele allele NN cord-015306-us58wwmp 2019 13 did do VBD cord-015306-us58wwmp 2019 14 not not RB cord-015306-us58wwmp 2019 15 differ differ VB cord-015306-us58wwmp 2019 16 significantly significantly RB cord-015306-us58wwmp 2019 17 from from IN cord-015306-us58wwmp 2019 18 those those DT cord-015306-us58wwmp 2019 19 of of IN cord-015306-us58wwmp 2019 20 children child NNS cord-015306-us58wwmp 2019 21 with with IN cord-015306-us58wwmp 2019 22 the the DT cord-015306-us58wwmp 2019 23 PP PP NNP cord-015306-us58wwmp 2019 24 genotype genotype NN cord-015306-us58wwmp 2019 25 of of IN cord-015306-us58wwmp 2019 26 the the DT cord-015306-us58wwmp 2019 27 PPAR PPAR NNP cord-015306-us58wwmp 2019 28 - - HYPH cord-015306-us58wwmp 2019 29 γ γ NN cord-015306-us58wwmp 2019 30 gene gene NN cord-015306-us58wwmp 2019 31 , , , cord-015306-us58wwmp 2019 32 their -PRON- PRP$ cord-015306-us58wwmp 2019 33 insulin insulin NN cord-015306-us58wwmp 2019 34 levels level NNS cord-015306-us58wwmp 2019 35 were be VBD cord-015306-us58wwmp 2019 36 decreased decrease VBN cord-015306-us58wwmp 2019 37 and and CC cord-015306-us58wwmp 2019 38 their -PRON- PRP$ cord-015306-us58wwmp 2019 39 ISI ISI NNP cord-015306-us58wwmp 2019 40 values value NNS cord-015306-us58wwmp 2019 41 were be VBD cord-015306-us58wwmp 2019 42 significantly significantly RB cord-015306-us58wwmp 2019 43 increased increase VBN cord-015306-us58wwmp 2019 44 ( ( -LRB- cord-015306-us58wwmp 2019 45 P=0.012 p=0.012 NN cord-015306-us58wwmp 2019 46 and and CC cord-015306-us58wwmp 2019 47 0.006 0.006 CD cord-015306-us58wwmp 2019 48 , , , cord-015306-us58wwmp 2019 49 respectively respectively RB cord-015306-us58wwmp 2019 50 ) ) -RRB- cord-015306-us58wwmp 2019 51 . . . cord-015306-us58wwmp 2020 1 The the DT cord-015306-us58wwmp 2020 2 triglycerides triglyceride NNS cord-015306-us58wwmp 2020 3 ( ( -LRB- cord-015306-us58wwmp 2020 4 TG TG NNP cord-015306-us58wwmp 2020 5 ) ) -RRB- cord-015306-us58wwmp 2020 6 levels level NNS cord-015306-us58wwmp 2020 7 of of IN cord-015306-us58wwmp 2020 8 children child NNS cord-015306-us58wwmp 2020 9 with with IN cord-015306-us58wwmp 2020 10 the the DT cord-015306-us58wwmp 2020 11 AA AA NNP cord-015306-us58wwmp 2020 12 genotype genotype NN cord-015306-us58wwmp 2020 13 of of IN cord-015306-us58wwmp 2020 14 the the DT cord-015306-us58wwmp 2020 15 PGC-1α PGC-1α NNP cord-015306-us58wwmp 2020 16 gene gene NN cord-015306-us58wwmp 2020 17 were be VBD cord-015306-us58wwmp 2020 18 significantly significantly RB cord-015306-us58wwmp 2020 19 increased increase VBN cord-015306-us58wwmp 2020 20 ( ( -LRB- cord-015306-us58wwmp 2020 21 P=0.026 P=0.026 NNP cord-015306-us58wwmp 2020 22 ) ) -RRB- cord-015306-us58wwmp 2020 23 . . . cord-015306-us58wwmp 2021 1 In in IN cord-015306-us58wwmp 2021 2 addition addition NN cord-015306-us58wwmp 2021 3 , , , cord-015306-us58wwmp 2021 4 the the DT cord-015306-us58wwmp 2021 5 PPAR PPAR NNP cord-015306-us58wwmp 2021 6 - - HYPH cord-015306-us58wwmp 2021 7 γ γ NNP cord-015306-us58wwmp 2021 8 ( ( -LRB- cord-015306-us58wwmp 2021 9 Val290Met val290met CD cord-015306-us58wwmp 2021 10 ) ) -RRB- cord-015306-us58wwmp 2021 11 and and CC cord-015306-us58wwmp 2021 12 PPAR PPAR NNP cord-015306-us58wwmp 2021 13 - - HYPH cord-015306-us58wwmp 2021 14 α α NNP cord-015306-us58wwmp 2021 15 ( ( -LRB- cord-015306-us58wwmp 2021 16 Leu162Val Leu162Val NNP cord-015306-us58wwmp 2021 17 ) ) -RRB- cord-015306-us58wwmp 2021 18 gene gene NN cord-015306-us58wwmp 2021 19 polymorphisms polymorphism NNS cord-015306-us58wwmp 2021 20 did do VBD cord-015306-us58wwmp 2021 21 not not RB cord-015306-us58wwmp 2021 22 show show VB cord-015306-us58wwmp 2021 23 any any DT cord-015306-us58wwmp 2021 24 mutations mutation NNS cord-015306-us58wwmp 2021 25 in in IN cord-015306-us58wwmp 2021 26 the the DT cord-015306-us58wwmp 2021 27 111 111 CD cord-015306-us58wwmp 2021 28 cases case NNS cord-015306-us58wwmp 2021 29 of of IN cord-015306-us58wwmp 2021 30 PNS PNS NNP cord-015306-us58wwmp 2021 31 in in IN cord-015306-us58wwmp 2021 32 children child NNS cord-015306-us58wwmp 2021 33 or or CC cord-015306-us58wwmp 2021 34 the the DT cord-015306-us58wwmp 2021 35 111 111 CD cord-015306-us58wwmp 2021 36 NC NC NNP cord-015306-us58wwmp 2021 37 children child NNS cord-015306-us58wwmp 2021 38 . . . cord-015306-us58wwmp 2022 1 Conclusion conclusion NN cord-015306-us58wwmp 2022 2 : : : cord-015306-us58wwmp 2023 1 The the DT cord-015306-us58wwmp 2023 2 Pro12Ala Pro12Ala NNP cord-015306-us58wwmp 2023 3 mutation mutation NN cord-015306-us58wwmp 2023 4 of of IN cord-015306-us58wwmp 2023 5 the the DT cord-015306-us58wwmp 2023 6 PPAR PPAR NNP cord-015306-us58wwmp 2023 7 - - HYPH cord-015306-us58wwmp 2023 8 γ γ NN cord-015306-us58wwmp 2023 9 gene gene NN cord-015306-us58wwmp 2023 10 may may MD cord-015306-us58wwmp 2023 11 be be VB cord-015306-us58wwmp 2023 12 correlated correlate VBN cord-015306-us58wwmp 2023 13 with with IN cord-015306-us58wwmp 2023 14 a a DT cord-015306-us58wwmp 2023 15 decrease decrease NN cord-015306-us58wwmp 2023 16 in in IN cord-015306-us58wwmp 2023 17 insulin insulin NN cord-015306-us58wwmp 2023 18 secretion secretion NN cord-015306-us58wwmp 2023 19 and and CC cord-015306-us58wwmp 2023 20 an an DT cord-015306-us58wwmp 2023 21 increase increase NN cord-015306-us58wwmp 2023 22 in in IN cord-015306-us58wwmp 2023 23 insulin insulin NN cord-015306-us58wwmp 2023 24 sensitivity sensitivity NN cord-015306-us58wwmp 2023 25 and and CC cord-015306-us58wwmp 2023 26 the the DT cord-015306-us58wwmp 2023 27 PGC-1α PGC-1α NNP cord-015306-us58wwmp 2023 28 ( ( -LRB- cord-015306-us58wwmp 2023 29 Gly482Ser gly482ser JJ cord-015306-us58wwmp 2023 30 ) ) -RRB- cord-015306-us58wwmp 2023 31 gene gene NN cord-015306-us58wwmp 2023 32 polymorphism polymorphism NN cord-015306-us58wwmp 2023 33 may may MD cord-015306-us58wwmp 2023 34 be be VB cord-015306-us58wwmp 2023 35 a a DT cord-015306-us58wwmp 2023 36 causative causative JJ cord-015306-us58wwmp 2023 37 genetic genetic JJ cord-015306-us58wwmp 2023 38 factor factor NN cord-015306-us58wwmp 2023 39 for for IN cord-015306-us58wwmp 2023 40 the the DT cord-015306-us58wwmp 2023 41 triglyceride triglyceride NN cord-015306-us58wwmp 2023 42 abnormalities abnormality NNS cord-015306-us58wwmp 2023 43 in in IN cord-015306-us58wwmp 2023 44 children child NNS cord-015306-us58wwmp 2023 45 with with IN cord-015306-us58wwmp 2023 46 PNS PNS NNP cord-015306-us58wwmp 2023 47 . . . cord-015306-us58wwmp 2024 1 The the DT cord-015306-us58wwmp 2024 2 relationship relationship NN cord-015306-us58wwmp 2024 3 between between IN cord-015306-us58wwmp 2024 4 endothelin-1 endothelin-1 NNP cord-015306-us58wwmp 2024 5 gene gene NN cord-015306-us58wwmp 2024 6 polymorphisms polymorphism NNS cord-015306-us58wwmp 2024 7 and and CC cord-015306-us58wwmp 2024 8 primary primary JJ cord-015306-us58wwmp 2024 9 nephrotic nephrotic JJ cord-015306-us58wwmp 2024 10 syndrome syndrome NN cord-015306-us58wwmp 2024 11 in in IN cord-015306-us58wwmp 2024 12 children child NNS cord-015306-us58wwmp 2025 1 Objective objective NN cord-015306-us58wwmp 2025 2 : : : cord-015306-us58wwmp 2025 3 NPHS1 nphs1 XX cord-015306-us58wwmp 2026 1 mutations mutation NNS cord-015306-us58wwmp 2026 2 have have VBP cord-015306-us58wwmp 2026 3 been be VBN cord-015306-us58wwmp 2026 4 reported report VBN cord-015306-us58wwmp 2026 5 in in IN cord-015306-us58wwmp 2026 6 CNS CNS NNP cord-015306-us58wwmp 2026 7 . . . cord-015306-us58wwmp 2027 1 However however RB cord-015306-us58wwmp 2027 2 , , , cord-015306-us58wwmp 2027 3 no no DT cord-015306-us58wwmp 2027 4 hot hot JJ cord-015306-us58wwmp 2027 5 mutation mutation NN cord-015306-us58wwmp 2027 6 has have VBZ cord-015306-us58wwmp 2027 7 been be VBN cord-015306-us58wwmp 2027 8 described describe VBN cord-015306-us58wwmp 2027 9 in in IN cord-015306-us58wwmp 2027 10 Chinese chinese JJ cord-015306-us58wwmp 2027 11 family family NN cord-015306-us58wwmp 2027 12 . . . cord-015306-us58wwmp 2028 1 In in IN cord-015306-us58wwmp 2028 2 this this DT cord-015306-us58wwmp 2028 3 study study NN cord-015306-us58wwmp 2028 4 , , , cord-015306-us58wwmp 2028 5 NPHS1 nphs1 NN cord-015306-us58wwmp 2028 6 mutations mutation NNS cord-015306-us58wwmp 2028 7 were be VBD cord-015306-us58wwmp 2028 8 analyzed analyze VBN cord-015306-us58wwmp 2028 9 in in IN cord-015306-us58wwmp 2028 10 a a DT cord-015306-us58wwmp 2028 11 Chinese chinese JJ cord-015306-us58wwmp 2028 12 family family NN cord-015306-us58wwmp 2028 13 with with IN cord-015306-us58wwmp 2028 14 two two CD cord-015306-us58wwmp 2028 15 siblings sibling NNS cord-015306-us58wwmp 2028 16 died die VBD cord-015306-us58wwmp 2028 17 of of IN cord-015306-us58wwmp 2028 18 CNS CNS NNP cord-015306-us58wwmp 2028 19 . . . cord-015306-us58wwmp 2029 1 Methods method NNS cord-015306-us58wwmp 2029 2 : : : cord-015306-us58wwmp 2030 1 Genomic genomic JJ cord-015306-us58wwmp 2030 2 DNA dna NN cord-015306-us58wwmp 2030 3 samples sample NNS cord-015306-us58wwmp 2030 4 were be VBD cord-015306-us58wwmp 2030 5 extracted extract VBN cord-015306-us58wwmp 2030 6 from from IN cord-015306-us58wwmp 2030 7 peripheral peripheral JJ cord-015306-us58wwmp 2030 8 blood blood NN cord-015306-us58wwmp 2030 9 of of IN cord-015306-us58wwmp 2030 10 the the DT cord-015306-us58wwmp 2030 11 proband proband NN cord-015306-us58wwmp 2030 12 , , , cord-015306-us58wwmp 2030 13 her -PRON- PRP$ cord-015306-us58wwmp 2030 14 parents parent NNS cord-015306-us58wwmp 2030 15 , , , cord-015306-us58wwmp 2030 16 and and CC cord-015306-us58wwmp 2030 17 150 150 CD cord-015306-us58wwmp 2030 18 unrelated unrelated JJ cord-015306-us58wwmp 2030 19 normal normal JJ cord-015306-us58wwmp 2030 20 individuals individual NNS cord-015306-us58wwmp 2030 21 . . . cord-015306-us58wwmp 2031 1 All all DT cord-015306-us58wwmp 2031 2 29 29 CD cord-015306-us58wwmp 2031 3 exons exon NNS cord-015306-us58wwmp 2031 4 of of IN cord-015306-us58wwmp 2031 5 NPHS1 NPHS1 NNS cord-015306-us58wwmp 2031 6 were be VBD cord-015306-us58wwmp 2031 7 detected detect VBN cord-015306-us58wwmp 2031 8 by by IN cord-015306-us58wwmp 2031 9 polymerase polymerase NN cord-015306-us58wwmp 2031 10 chain chain NN cord-015306-us58wwmp 2031 11 reaction(PCR reaction(PCR NNP cord-015306-us58wwmp 2031 12 ) ) -RRB- cord-015306-us58wwmp 2031 13 and and CC cord-015306-us58wwmp 2031 14 direct direct JJ cord-015306-us58wwmp 2031 15 DNA dna NN cord-015306-us58wwmp 2031 16 sequencing sequencing NN cord-015306-us58wwmp 2031 17 . . . cord-015306-us58wwmp 2032 1 Results result NNS cord-015306-us58wwmp 2032 2 : : : cord-015306-us58wwmp 2033 1 The the DT cord-015306-us58wwmp 2033 2 proband proband NN cord-015306-us58wwmp 2033 3 , , , cord-015306-us58wwmp 2033 4 a a DT cord-015306-us58wwmp 2033 5 15-day 15-day CD cord-015306-us58wwmp 2033 6 - - HYPH cord-015306-us58wwmp 2033 7 old old JJ cord-015306-us58wwmp 2033 8 girl girl NN cord-015306-us58wwmp 2033 9 , , , cord-015306-us58wwmp 2033 10 weighed weigh VBD cord-015306-us58wwmp 2033 11 3500 3500 CD cord-015306-us58wwmp 2033 12 g g NN cord-015306-us58wwmp 2033 13 at at IN cord-015306-us58wwmp 2033 14 birth birth NN cord-015306-us58wwmp 2033 15 . . . cord-015306-us58wwmp 2034 1 The the DT cord-015306-us58wwmp 2034 2 placenta placenta NN cord-015306-us58wwmp 2034 3 was be VBD cord-015306-us58wwmp 2034 4 one one CD cord-015306-us58wwmp 2034 5 time time NN cord-015306-us58wwmp 2034 6 heavier heavy JJR cord-015306-us58wwmp 2034 7 than than IN cord-015306-us58wwmp 2034 8 usual usual JJ cord-015306-us58wwmp 2034 9 . . . cord-015306-us58wwmp 2035 1 She -PRON- PRP cord-015306-us58wwmp 2035 2 was be VBD cord-015306-us58wwmp 2035 3 hospitalized hospitalize VBN cord-015306-us58wwmp 2035 4 with with IN cord-015306-us58wwmp 2035 5 edema edema NN cord-015306-us58wwmp 2035 6 of of IN cord-015306-us58wwmp 2035 7 legs leg NNS cord-015306-us58wwmp 2035 8 , , , cord-015306-us58wwmp 2035 9 heavy heavy JJ cord-015306-us58wwmp 2035 10 proteinuria(+++ proteinuria(+++ NNP cord-015306-us58wwmp 2035 11 ) ) -RRB- cord-015306-us58wwmp 2035 12 , , , cord-015306-us58wwmp 2035 13 and and CC cord-015306-us58wwmp 2035 14 hematuresis(+++ hematuresis(+++ NNP cord-015306-us58wwmp 2035 15 ) ) -RRB- cord-015306-us58wwmp 2035 16 . . . cord-015306-us58wwmp 2036 1 Two two CD cord-015306-us58wwmp 2036 2 compound compound NN cord-015306-us58wwmp 2036 3 heterozygous heterozygous JJ cord-015306-us58wwmp 2036 4 mutations mutation NNS cord-015306-us58wwmp 2036 5 were be VBD cord-015306-us58wwmp 2036 6 identified identify VBN cord-015306-us58wwmp 2036 7 in in IN cord-015306-us58wwmp 2036 8 exon exon NN cord-015306-us58wwmp 2036 9 15 15 CD cord-015306-us58wwmp 2036 10 ( ( -LRB- cord-015306-us58wwmp 2036 11 c.2020C c.2020C NFP cord-015306-us58wwmp 2037 1 > > XX cord-015306-us58wwmp 2038 1 T T NNP cord-015306-us58wwmp 2038 2 , , , cord-015306-us58wwmp 2038 3 p p NN cord-015306-us58wwmp 2038 4 . . . cord-015306-us58wwmp 2038 5 P674S P674S NNP cord-015306-us58wwmp 2038 6 ) ) -RRB- cord-015306-us58wwmp 2038 7 , , , cord-015306-us58wwmp 2038 8 which which WDT cord-015306-us58wwmp 2038 9 was be VBD cord-015306-us58wwmp 2038 10 detected detect VBN cord-015306-us58wwmp 2038 11 in in IN cord-015306-us58wwmp 2038 12 her -PRON- PRP$ cord-015306-us58wwmp 2038 13 father father NN cord-015306-us58wwmp 2038 14 , , , cord-015306-us58wwmp 2038 15 and and CC cord-015306-us58wwmp 2038 16 in in IN cord-015306-us58wwmp 2038 17 exon exon NN cord-015306-us58wwmp 2038 18 16(c.2207 16(c.2207 CD cord-015306-us58wwmp 2038 19 T t NN cord-015306-us58wwmp 2039 1 > > XX cord-015306-us58wwmp 2039 2 C C NNP cord-015306-us58wwmp 2039 3 , , , cord-015306-us58wwmp 2039 4 p p NN cord-015306-us58wwmp 2039 5 . . . cord-015306-us58wwmp 2039 6 V736A V736A NNP cord-015306-us58wwmp 2039 7 ) ) -RRB- cord-015306-us58wwmp 2039 8 , , , cord-015306-us58wwmp 2039 9 which which WDT cord-015306-us58wwmp 2039 10 was be VBD cord-015306-us58wwmp 2039 11 also also RB cord-015306-us58wwmp 2039 12 detected detect VBN cord-015306-us58wwmp 2039 13 in in IN cord-015306-us58wwmp 2039 14 her -PRON- PRP$ cord-015306-us58wwmp 2039 15 mother mother NN cord-015306-us58wwmp 2039 16 . . . cord-015306-us58wwmp 2040 1 These these DT cord-015306-us58wwmp 2040 2 two two CD cord-015306-us58wwmp 2040 3 new new JJ cord-015306-us58wwmp 2040 4 mutations mutation NNS cord-015306-us58wwmp 2040 5 were be VBD cord-015306-us58wwmp 2040 6 not not RB cord-015306-us58wwmp 2040 7 found find VBN cord-015306-us58wwmp 2040 8 in in IN cord-015306-us58wwmp 2040 9 the the DT cord-015306-us58wwmp 2040 10 150 150 CD cord-015306-us58wwmp 2040 11 Chinese chinese JJ cord-015306-us58wwmp 2040 12 controls control NNS cord-015306-us58wwmp 2040 13 . . . cord-015306-us58wwmp 2041 1 Conclusion conclusion NN cord-015306-us58wwmp 2041 2 : : : cord-015306-us58wwmp 2041 3 New new JJ cord-015306-us58wwmp 2041 4 compound compound NN cord-015306-us58wwmp 2041 5 heterozygous heterozygous JJ cord-015306-us58wwmp 2042 1 NPHS1 NPHS1 NNP cord-015306-us58wwmp 2042 2 mutations mutation NNS cord-015306-us58wwmp 2042 3 ( ( -LRB- cord-015306-us58wwmp 2042 4 c.2020C c.2020C NFP cord-015306-us58wwmp 2043 1 > > XX cord-015306-us58wwmp 2044 1 T T NNP cord-015306-us58wwmp 2044 2 and and CC cord-015306-us58wwmp 2044 3 c.2207T c.2207t NN cord-015306-us58wwmp 2044 4 > > XX cord-015306-us58wwmp 2044 5 C C NNP cord-015306-us58wwmp 2044 6 ) ) -RRB- cord-015306-us58wwmp 2044 7 were be VBD cord-015306-us58wwmp 2044 8 identified identify VBN cord-015306-us58wwmp 2044 9 in in IN cord-015306-us58wwmp 2044 10 a a DT cord-015306-us58wwmp 2044 11 Chinese chinese JJ cord-015306-us58wwmp 2044 12 family family NN cord-015306-us58wwmp 2044 13 with with IN cord-015306-us58wwmp 2044 14 two two CD cord-015306-us58wwmp 2044 15 siblings sibling NNS cord-015306-us58wwmp 2044 16 of of IN cord-015306-us58wwmp 2044 17 congenital congenital JJ cord-015306-us58wwmp 2044 18 nephrotic nephrotic JJ cord-015306-us58wwmp 2044 19 syndrome syndrome NN cord-015306-us58wwmp 2044 20 , , , cord-015306-us58wwmp 2044 21 which which WDT cord-015306-us58wwmp 2044 22 were be VBD cord-015306-us58wwmp 2044 23 suggested suggest VBN cord-015306-us58wwmp 2044 24 to to TO cord-015306-us58wwmp 2044 25 be be VB cord-015306-us58wwmp 2044 26 the the DT cord-015306-us58wwmp 2044 27 causative causative JJ cord-015306-us58wwmp 2044 28 mutations mutation NNS cord-015306-us58wwmp 2044 29 in in IN cord-015306-us58wwmp 2044 30 this this DT cord-015306-us58wwmp 2044 31 family family NN cord-015306-us58wwmp 2044 32 . . . cord-015306-us58wwmp 2045 1 The the DT cord-015306-us58wwmp 2045 2 compound compound NN cord-015306-us58wwmp 2045 3 heterozygous heterozygous JJ cord-015306-us58wwmp 2045 4 mutations mutation NNS cord-015306-us58wwmp 2045 5 ( ( -LRB- cord-015306-us58wwmp 2045 6 c.2020C c.2020C NFP cord-015306-us58wwmp 2046 1 > > XX cord-015306-us58wwmp 2047 1 T T NNP cord-015306-us58wwmp 2047 2 and and CC cord-015306-us58wwmp 2048 1 c.2207T c.2207t NN cord-015306-us58wwmp 2048 2 > > XX cord-015306-us58wwmp 2048 3 C c NN cord-015306-us58wwmp 2048 4 ) ) -RRB- cord-015306-us58wwmp 2048 5 lie lie VBP cord-015306-us58wwmp 2048 6 between between IN cord-015306-us58wwmp 2048 7 Ig6 ig6 PRP cord-015306-us58wwmp 2048 8 and and CC cord-015306-us58wwmp 2048 9 Ig7 ig7 CD cord-015306-us58wwmp 2048 10 domain domain NN cord-015306-us58wwmp 2048 11 which which WDT cord-015306-us58wwmp 2048 12 has have VBZ cord-015306-us58wwmp 2048 13 a a DT cord-015306-us58wwmp 2048 14 free free JJ cord-015306-us58wwmp 2048 15 cysteine cysteine NN cord-015306-us58wwmp 2048 16 residues residue NNS cord-015306-us58wwmp 2048 17 . . . cord-015306-us58wwmp 2049 1 These these DT cord-015306-us58wwmp 2049 2 mutations mutation NNS cord-015306-us58wwmp 2049 3 might may MD cord-015306-us58wwmp 2049 4 cause cause VB cord-015306-us58wwmp 2049 5 misfolding misfolde VBG cord-015306-us58wwmp 2049 6 and and CC cord-015306-us58wwmp 2049 7 defective defective JJ cord-015306-us58wwmp 2049 8 intracellular intracellular JJ cord-015306-us58wwmp 2049 9 transport transport NN cord-015306-us58wwmp 2049 10 , , , cord-015306-us58wwmp 2049 11 with with IN cord-015306-us58wwmp 2049 12 consequent consequent JJ cord-015306-us58wwmp 2049 13 absence absence NN cord-015306-us58wwmp 2049 14 of of IN cord-015306-us58wwmp 2049 15 the the DT cord-015306-us58wwmp 2049 16 mutant mutant JJ cord-015306-us58wwmp 2049 17 nephrin nephrin NN cord-015306-us58wwmp 2049 18 on on IN cord-015306-us58wwmp 2049 19 the the DT cord-015306-us58wwmp 2049 20 plasma plasma NN cord-015306-us58wwmp 2049 21 membrane membrane NN cord-015306-us58wwmp 2049 22 . . . cord-015306-us58wwmp 2050 1 Abstract abstract JJ cord-015306-us58wwmp 2050 2 # # NN cord-015306-us58wwmp 2050 3 P p NN cord-015306-us58wwmp 2050 4 - - HYPH cord-015306-us58wwmp 2050 5 SAT255 SAT255 NNP cord-015306-us58wwmp 2050 6 Sporadic sporadic JJ cord-015306-us58wwmp 2050 7 MYH9-related myh9-relate VBN cord-015306-us58wwmp 2050 8 disease disease NN cord-015306-us58wwmp 2050 9 : : : cord-015306-us58wwmp 2050 10 a a DT cord-015306-us58wwmp 2050 11 case case NN cord-015306-us58wwmp 2050 12 report report NN cord-015306-us58wwmp 2050 13 and and CC cord-015306-us58wwmp 2050 14 mutational mutational JJ cord-015306-us58wwmp 2050 15 analysis analysis NN cord-015306-us58wwmp 2050 16 of of IN cord-015306-us58wwmp 2050 17 MYH9 MYH9 NNP cord-015306-us58wwmp 2050 18 gene gene NN cord-015306-us58wwmp 2050 19 .Genetic .Genetic NNP cord-015306-us58wwmp 2050 20 analysis analysis NN cord-015306-us58wwmp 2050 21 confirmed confirm VBD cord-015306-us58wwmp 2050 22 that that IN cord-015306-us58wwmp 2050 23 these these DT cord-015306-us58wwmp 2050 24 three three CD cord-015306-us58wwmp 2050 25 cases case NNS cord-015306-us58wwmp 2050 26 had have VBD cord-015306-us58wwmp 2050 27 intron intron NNP cord-015306-us58wwmp 2050 28 9 9 CD cord-015306-us58wwmp 2050 29 ( ( -LRB- cord-015306-us58wwmp 2050 30 + + `` cord-015306-us58wwmp 2050 31 KTS kts NN cord-015306-us58wwmp 2050 32 ) ) -RRB- cord-015306-us58wwmp 2050 33 mutation mutation NN cord-015306-us58wwmp 2050 34 . . . cord-015306-us58wwmp 2051 1 After after IN cord-015306-us58wwmp 2051 2 confirmation confirmation NN cord-015306-us58wwmp 2051 3 of of IN cord-015306-us58wwmp 2051 4 FS FS NNP cord-015306-us58wwmp 2051 5 , , , cord-015306-us58wwmp 2051 6 Cytogenetic Cytogenetic NNP cord-015306-us58wwmp 2051 7 analysis analysis NN cord-015306-us58wwmp 2051 8 showed show VBD cord-015306-us58wwmp 2051 9 XY XY NNP cord-015306-us58wwmp 2051 10 in in IN cord-015306-us58wwmp 2051 11 girls girl NNS cord-015306-us58wwmp 2051 12 though though IN cord-015306-us58wwmp 2051 13 phenotypically phenotypically RB cord-015306-us58wwmp 2051 14 there there EX cord-015306-us58wwmp 2051 15 were be VBD cord-015306-us58wwmp 2051 16 females female NNS cord-015306-us58wwmp 2051 17 . . . cord-015306-us58wwmp 2052 1 Abdominal abdominal JJ cord-015306-us58wwmp 2052 2 ultrasound ultrasound NN cord-015306-us58wwmp 2052 3 in in IN cord-015306-us58wwmp 2052 4 them -PRON- PRP cord-015306-us58wwmp 2052 5 showed show VBD cord-015306-us58wwmp 2052 6 normal normal JJ cord-015306-us58wwmp 2052 7 uterus uterus NN cord-015306-us58wwmp 2052 8 with with IN cord-015306-us58wwmp 2052 9 streak streak NN cord-015306-us58wwmp 2052 10 gonads gonad NNS cord-015306-us58wwmp 2052 11 and and CC cord-015306-us58wwmp 2052 12 gonadectomy gonadectomy NN cord-015306-us58wwmp 2052 13 was be VBD cord-015306-us58wwmp 2052 14 done do VBN cord-015306-us58wwmp 2052 15 for for IN cord-015306-us58wwmp 2052 16 both both DT cord-015306-us58wwmp 2052 17 and and CC cord-015306-us58wwmp 2052 18 histologically histologically RB cord-015306-us58wwmp 2052 19 reported report VBD cord-015306-us58wwmp 2052 20 as as IN cord-015306-us58wwmp 2052 21 Dysgerminoma Dysgerminoma NNP cord-015306-us58wwmp 2052 22 stage stage NN cord-015306-us58wwmp 2052 23 I. I. NNP cord-015306-us58wwmp 2052 24 Familial familial JJ cord-015306-us58wwmp 2052 25 girl girl NN cord-015306-us58wwmp 2052 26 aged age VBN cord-015306-us58wwmp 2052 27 12 12 CD cord-015306-us58wwmp 2052 28 entered enter VBN cord-015306-us58wwmp 2052 29 ESRD ESRD NNP cord-015306-us58wwmp 2052 30 and and CC cord-015306-us58wwmp 2052 31 received receive VBD cord-015306-us58wwmp 2052 32 live live RB cord-015306-us58wwmp 2052 33 related related JJ cord-015306-us58wwmp 2052 34 renal renal JJ cord-015306-us58wwmp 2052 35 transplant transplant NN cord-015306-us58wwmp 2052 36 from from IN cord-015306-us58wwmp 2052 37 her -PRON- PRP$ cord-015306-us58wwmp 2052 38 mother mother NN cord-015306-us58wwmp 2052 39 . . . cord-015306-us58wwmp 2053 1 The the DT cord-015306-us58wwmp 2053 2 sporadic sporadic JJ cord-015306-us58wwmp 2053 3 girl girl NN cord-015306-us58wwmp 2053 4 aged age VBN cord-015306-us58wwmp 2053 5 9 9 CD cord-015306-us58wwmp 2053 6 years year NNS cord-015306-us58wwmp 2053 7 also also RB cord-015306-us58wwmp 2053 8 entered enter VBD cord-015306-us58wwmp 2053 9 end end JJ cord-015306-us58wwmp 2053 10 stage stage NN cord-015306-us58wwmp 2053 11 renal renal JJ cord-015306-us58wwmp 2053 12 disease disease NN cord-015306-us58wwmp 2053 13 rapidly rapidly RB cord-015306-us58wwmp 2053 14 and and CC cord-015306-us58wwmp 2053 15 died die VBD cord-015306-us58wwmp 2053 16 . . . cord-015306-us58wwmp 2054 1 The the DT cord-015306-us58wwmp 2054 2 third third JJ cord-015306-us58wwmp 2054 3 was be VBD cord-015306-us58wwmp 2054 4 a a DT cord-015306-us58wwmp 2054 5 nephrotic nephrotic JJ cord-015306-us58wwmp 2054 6 boy boy NN cord-015306-us58wwmp 2054 7 aged age VBN cord-015306-us58wwmp 2054 8 9 9 CD cord-015306-us58wwmp 2054 9 years year NNS cord-015306-us58wwmp 2054 10 with with IN cord-015306-us58wwmp 2054 11 FS FS NNP cord-015306-us58wwmp 2054 12 . . . cord-015306-us58wwmp 2055 1 He -PRON- PRP cord-015306-us58wwmp 2055 2 had have VBD cord-015306-us58wwmp 2055 3 bilateral bilateral JJ cord-015306-us58wwmp 2055 4 hypoplastic hypoplastic JJ cord-015306-us58wwmp 2055 5 testes testis NNS cord-015306-us58wwmp 2055 6 . . . cord-015306-us58wwmp 2056 1 His -PRON- PRP$ cord-015306-us58wwmp 2056 2 chromosome chromosome NN cord-015306-us58wwmp 2056 3 was be VBD cord-015306-us58wwmp 2056 4 XY XY NNP cord-015306-us58wwmp 2056 5 . . . cord-015306-us58wwmp 2057 1 Renal renal JJ cord-015306-us58wwmp 2057 2 biopsy biopsy NN cord-015306-us58wwmp 2057 3 showed show VBD cord-015306-us58wwmp 2057 4 MCD MCD NNP cord-015306-us58wwmp 2057 5 with with IN cord-015306-us58wwmp 2057 6 IgM IgM NNP cord-015306-us58wwmp 2057 7 deposits deposit NNS cord-015306-us58wwmp 2057 8 and and CC cord-015306-us58wwmp 2057 9 partially partially RB cord-015306-us58wwmp 2057 10 responding respond VBG cord-015306-us58wwmp 2057 11 to to IN cord-015306-us58wwmp 2057 12 therapy therapy NN cord-015306-us58wwmp 2057 13 . . . cord-015306-us58wwmp 2057 14 _SP cord-015306-us58wwmp 2058 1 A a DT cord-015306-us58wwmp 2058 2 six six CD cord-015306-us58wwmp 2058 3 year year NN cord-015306-us58wwmp 2058 4 old old JJ cord-015306-us58wwmp 2058 5 girl girl NN cord-015306-us58wwmp 2058 6 presented present VBN cord-015306-us58wwmp 2058 7 at at IN cord-015306-us58wwmp 2058 8 the the DT cord-015306-us58wwmp 2058 9 emergency emergency NN cord-015306-us58wwmp 2058 10 department department NN cord-015306-us58wwmp 2058 11 with with IN cord-015306-us58wwmp 2058 12 a a DT cord-015306-us58wwmp 2058 13 history history NN cord-015306-us58wwmp 2058 14 of of IN cord-015306-us58wwmp 2058 15 3 3 CD cord-015306-us58wwmp 2058 16 episodes episode NNS cord-015306-us58wwmp 2058 17 of of IN cord-015306-us58wwmp 2058 18 vomiting vomit VBG cord-015306-us58wwmp 2058 19 in in IN cord-015306-us58wwmp 2058 20 24 24 CD cord-015306-us58wwmp 2058 21 hours hour NNS cord-015306-us58wwmp 2058 22 . . . cord-015306-us58wwmp 2059 1 She -PRON- PRP cord-015306-us58wwmp 2059 2 had have VBD cord-015306-us58wwmp 2059 3 a a DT cord-015306-us58wwmp 2059 4 history history NN cord-015306-us58wwmp 2059 5 of of IN cord-015306-us58wwmp 2059 6 polyuria polyuria NN cord-015306-us58wwmp 2059 7 and and CC cord-015306-us58wwmp 2059 8 polydipsia polydipsia NN cord-015306-us58wwmp 2059 9 with with IN cord-015306-us58wwmp 2059 10 a a DT cord-015306-us58wwmp 2059 11 current current JJ cord-015306-us58wwmp 2059 12 daily daily JJ cord-015306-us58wwmp 2059 13 intake intake NN cord-015306-us58wwmp 2059 14 of of IN cord-015306-us58wwmp 2059 15 3 3 CD cord-015306-us58wwmp 2059 16 liters liter NNS cord-015306-us58wwmp 2059 17 . . . cord-015306-us58wwmp 2060 1 Physical physical JJ cord-015306-us58wwmp 2060 2 examination examination NN cord-015306-us58wwmp 2060 3 revealed reveal VBD cord-015306-us58wwmp 2060 4 signs sign NNS cord-015306-us58wwmp 2060 5 of of IN cord-015306-us58wwmp 2060 6 mild mild JJ cord-015306-us58wwmp 2060 7 dehydration dehydration NN cord-015306-us58wwmp 2060 8 . . . cord-015306-us58wwmp 2061 1 Plasma plasma NN cord-015306-us58wwmp 2061 2 electrolytes electrolyte NNS cord-015306-us58wwmp 2061 3 revealed reveal VBD cord-015306-us58wwmp 2061 4 hyponatremia hyponatremia NN cord-015306-us58wwmp 2061 5 ( ( -LRB- cord-015306-us58wwmp 2061 6 128 128 CD cord-015306-us58wwmp 2061 7 mmol mmol JJ cord-015306-us58wwmp 2061 8 / / SYM cord-015306-us58wwmp 2061 9 l l NN cord-015306-us58wwmp 2061 10 ) ) -RRB- cord-015306-us58wwmp 2061 11 , , , cord-015306-us58wwmp 2061 12 hypokaliemia hypokaliemia NNP cord-015306-us58wwmp 2061 13 ( ( -LRB- cord-015306-us58wwmp 2061 14 1.6 1.6 CD cord-015306-us58wwmp 2061 15 mmol mmol JJ cord-015306-us58wwmp 2061 16 / / SYM cord-015306-us58wwmp 2061 17 l l NN cord-015306-us58wwmp 2061 18 ) ) -RRB- cord-015306-us58wwmp 2061 19 , , , cord-015306-us58wwmp 2061 20 metabolic metabolic JJ cord-015306-us58wwmp 2061 21 acidosis acidosis NN cord-015306-us58wwmp 2061 22 with with IN cord-015306-us58wwmp 2061 23 normal normal JJ cord-015306-us58wwmp 2061 24 anion anion NN cord-015306-us58wwmp 2061 25 gap gap NN cord-015306-us58wwmp 2061 26 ( ( -LRB- cord-015306-us58wwmp 2061 27 14 14 CD cord-015306-us58wwmp 2061 28 mmol mmol JJ cord-015306-us58wwmp 2061 29 / / SYM cord-015306-us58wwmp 2061 30 l l NNP cord-015306-us58wwmp 2061 31 ) ) -RRB- cord-015306-us58wwmp 2061 32 , , , cord-015306-us58wwmp 2061 33 hypophosphatemia hypophosphatemia NNP cord-015306-us58wwmp 2061 34 ( ( -LRB- cord-015306-us58wwmp 2061 35 0.86 0.86 CD cord-015306-us58wwmp 2061 36 mmol mmol NNP cord-015306-us58wwmp 2061 37 / / SYM cord-015306-us58wwmp 2061 38 l l NN cord-015306-us58wwmp 2061 39 ) ) -RRB- cord-015306-us58wwmp 2061 40 , , . cord-015306-us58wwmp 2062 1 hypouricemia hypouricemia NNP cord-015306-us58wwmp 2062 2 ( ( -LRB- cord-015306-us58wwmp 2062 3 90 90 CD cord-015306-us58wwmp 2062 4 umol umol NNP cord-015306-us58wwmp 2062 5 / / SYM cord-015306-us58wwmp 2062 6 l l NN cord-015306-us58wwmp 2062 7 ) ) -RRB- cord-015306-us58wwmp 2062 8 and and CC cord-015306-us58wwmp 2062 9 normal normal JJ cord-015306-us58wwmp 2062 10 serum serum NN cord-015306-us58wwmp 2062 11 creatinine creatinine NN cord-015306-us58wwmp 2062 12 ( ( -LRB- cord-015306-us58wwmp 2062 13 29 29 CD cord-015306-us58wwmp 2062 14 umol umol NNP cord-015306-us58wwmp 2062 15 / / SYM cord-015306-us58wwmp 2062 16 l l NN cord-015306-us58wwmp 2062 17 ) ) -RRB- cord-015306-us58wwmp 2062 18 . . . cord-015306-us58wwmp 2063 1 Urinalysis urinalysis NN cord-015306-us58wwmp 2063 2 confirmed confirm VBD cord-015306-us58wwmp 2063 3 the the DT cord-015306-us58wwmp 2063 4 Na Na NNP cord-015306-us58wwmp 2063 5 , , , cord-015306-us58wwmp 2063 6 K K NNP cord-015306-us58wwmp 2063 7 , , , cord-015306-us58wwmp 2063 8 Ph Ph NNP cord-015306-us58wwmp 2063 9 and and CC cord-015306-us58wwmp 2063 10 acid acid JJ cord-015306-us58wwmp 2063 11 uric uric NN cord-015306-us58wwmp 2063 12 losses loss NNS cord-015306-us58wwmp 2063 13 : : : cord-015306-us58wwmp 2063 14 Na Na NNP cord-015306-us58wwmp 2063 15 ( ( -LRB- cord-015306-us58wwmp 2063 16 67 67 CD cord-015306-us58wwmp 2063 17 mmol mmol JJ cord-015306-us58wwmp 2063 18 / / SYM cord-015306-us58wwmp 2063 19 l l NN cord-015306-us58wwmp 2063 20 , , , cord-015306-us58wwmp 2063 21 fractional fractional JJ cord-015306-us58wwmp 2063 22 excretion excretion NN cord-015306-us58wwmp 2063 23 2 2 CD cord-015306-us58wwmp 2063 24 % % NN cord-015306-us58wwmp 2063 25 ) ) -RRB- cord-015306-us58wwmp 2063 26 , , , cord-015306-us58wwmp 2063 27 K K NNP cord-015306-us58wwmp 2063 28 ( ( -LRB- cord-015306-us58wwmp 2063 29 83 83 CD cord-015306-us58wwmp 2063 30 mmol mmol NNP cord-015306-us58wwmp 2063 31 / / SYM cord-015306-us58wwmp 2063 32 l l NN cord-015306-us58wwmp 2063 33 , , , cord-015306-us58wwmp 2063 34 TTKG TTKG NNP cord-015306-us58wwmp 2063 35 30 30 CD cord-015306-us58wwmp 2063 36 ) ) -RRB- cord-015306-us58wwmp 2063 37 , , , cord-015306-us58wwmp 2063 38 tubular tubular JJ cord-015306-us58wwmp 2063 39 phosphate phosphate NN cord-015306-us58wwmp 2063 40 reabsorption reabsorption NN cord-015306-us58wwmp 2063 41 of of IN cord-015306-us58wwmp 2063 42 18 18 CD cord-015306-us58wwmp 2063 43 % % NN cord-015306-us58wwmp 2063 44 , , , cord-015306-us58wwmp 2063 45 and and CC cord-015306-us58wwmp 2063 46 fractional fractional JJ cord-015306-us58wwmp 2063 47 excretion excretion NN cord-015306-us58wwmp 2063 48 of of IN cord-015306-us58wwmp 2063 49 uric uric NN cord-015306-us58wwmp 2063 50 acid acid NN cord-015306-us58wwmp 2063 51 of of IN cord-015306-us58wwmp 2063 52 30 30 CD cord-015306-us58wwmp 2063 53 % % NN cord-015306-us58wwmp 2063 54 . . . cord-015306-us58wwmp 2064 1 Cystine cystine JJ cord-015306-us58wwmp 2064 2 level level NN cord-015306-us58wwmp 2064 3 in in IN cord-015306-us58wwmp 2064 4 leucocytes leucocyte NNS cord-015306-us58wwmp 2064 5 was be VBD cord-015306-us58wwmp 2064 6 normal normal JJ cord-015306-us58wwmp 2064 7 . . . cord-015306-us58wwmp 2065 1 She -PRON- PRP cord-015306-us58wwmp 2065 2 was be VBD cord-015306-us58wwmp 2065 3 discharged discharge VBN cord-015306-us58wwmp 2065 4 six six CD cord-015306-us58wwmp 2065 5 days day NNS cord-015306-us58wwmp 2065 6 later later RB cord-015306-us58wwmp 2065 7 with with IN cord-015306-us58wwmp 2065 8 oral oral JJ cord-015306-us58wwmp 2065 9 supplementation supplementation NN cord-015306-us58wwmp 2065 10 of of IN cord-015306-us58wwmp 2065 11 potassium potassium NN cord-015306-us58wwmp 2065 12 and and CC cord-015306-us58wwmp 2065 13 phosphorus phosphorus NN cord-015306-us58wwmp 2065 14 . . . cord-015306-us58wwmp 2066 1 Laboratory laboratory NN cord-015306-us58wwmp 2066 2 studies study NNS cord-015306-us58wwmp 2066 3 3 3 CD cord-015306-us58wwmp 2066 4 weeks week NNS cord-015306-us58wwmp 2066 5 later later RB cord-015306-us58wwmp 2066 6 revealed reveal VBD cord-015306-us58wwmp 2066 7 surprising surprising JJ cord-015306-us58wwmp 2066 8 findings finding NNS cord-015306-us58wwmp 2066 9 with with IN cord-015306-us58wwmp 2066 10 persistent persistent JJ cord-015306-us58wwmp 2066 11 hypokaliemia hypokaliemia NN cord-015306-us58wwmp 2066 12 ( ( -LRB- cord-015306-us58wwmp 2066 13 3 3 CD cord-015306-us58wwmp 2066 14 mmol mmol JJ cord-015306-us58wwmp 2066 15 / / SYM cord-015306-us58wwmp 2066 16 l l NN cord-015306-us58wwmp 2066 17 ) ) -RRB- cord-015306-us58wwmp 2066 18 , , , cord-015306-us58wwmp 2066 19 metabolic metabolic JJ cord-015306-us58wwmp 2066 20 alcalosis alcalosis NN cord-015306-us58wwmp 2066 21 ( ( -LRB- cord-015306-us58wwmp 2066 22 HCO3 HCO3 NNP cord-015306-us58wwmp 2066 23 30 30 CD cord-015306-us58wwmp 2066 24 mmol mmol NN cord-015306-us58wwmp 2066 25 / / SYM cord-015306-us58wwmp 2066 26 l l NN cord-015306-us58wwmp 2066 27 ) ) -RRB- cord-015306-us58wwmp 2066 28 , , , cord-015306-us58wwmp 2066 29 hypomagnesemia hypomagnesemia NNP cord-015306-us58wwmp 2066 30 ( ( -LRB- cord-015306-us58wwmp 2066 31 0.65 0.65 CD cord-015306-us58wwmp 2066 32 mmol mmol NNP cord-015306-us58wwmp 2066 33 / / SYM cord-015306-us58wwmp 2066 34 l l NN cord-015306-us58wwmp 2066 35 ) ) -RRB- cord-015306-us58wwmp 2066 36 , , , cord-015306-us58wwmp 2066 37 and and CC cord-015306-us58wwmp 2066 38 hypocalciuria hypocalciuria NNP cord-015306-us58wwmp 2066 39 ( ( -LRB- cord-015306-us58wwmp 2066 40 calcium calcium NN cord-015306-us58wwmp 2066 41 / / SYM cord-015306-us58wwmp 2066 42 creatinine creatinine NN cord-015306-us58wwmp 2066 43 0.06 0.06 CD cord-015306-us58wwmp 2066 44 mmol mmol JJ cord-015306-us58wwmp 2066 45 / / SYM cord-015306-us58wwmp 2066 46 mmol mmol NN cord-015306-us58wwmp 2066 47 ) ) -RRB- cord-015306-us58wwmp 2066 48 . . . cord-015306-us58wwmp 2067 1 We -PRON- PRP cord-015306-us58wwmp 2067 2 therefore therefore RB cord-015306-us58wwmp 2067 3 sequenced sequence VBD cord-015306-us58wwmp 2067 4 the the DT cord-015306-us58wwmp 2067 5 SLC12A3 slc12a3 NN cord-015306-us58wwmp 2067 6 gene gene NN cord-015306-us58wwmp 2067 7 and and CC cord-015306-us58wwmp 2067 8 we -PRON- PRP cord-015306-us58wwmp 2067 9 found find VBD cord-015306-us58wwmp 2067 10 that that IN cord-015306-us58wwmp 2067 11 she -PRON- PRP cord-015306-us58wwmp 2067 12 is be VBZ cord-015306-us58wwmp 2067 13 compound compound JJ cord-015306-us58wwmp 2067 14 heterozygous heterozygous JJ cord-015306-us58wwmp 2067 15 for for IN cord-015306-us58wwmp 2067 16 2 2 CD cord-015306-us58wwmp 2067 17 known know VBN cord-015306-us58wwmp 2067 18 missense missense NN cord-015306-us58wwmp 2067 19 mutations mutation NNS cord-015306-us58wwmp 2067 20 ( ( -LRB- cord-015306-us58wwmp 2067 21 p. p. NN cord-015306-us58wwmp 2068 1 Thr304Met Thr304Met NNP cord-015306-us58wwmp 2068 2 and and CC cord-015306-us58wwmp 2068 3 p p NN cord-015306-us58wwmp 2068 4 . . . cord-015306-us58wwmp 2068 5 Gly439Ser Gly439Ser NNP cord-015306-us58wwmp 2068 6 ) ) -RRB- cord-015306-us58wwmp 2069 1 . . . cord-015306-us58wwmp 2070 1 Conclusion conclusion NN cord-015306-us58wwmp 2070 2 : : : cord-015306-us58wwmp 2071 1 GS GS NNP cord-015306-us58wwmp 2071 2 can can MD cord-015306-us58wwmp 2071 3 have have VB cord-015306-us58wwmp 2071 4 atypical atypical JJ cord-015306-us58wwmp 2071 5 presentations presentation NNS cord-015306-us58wwmp 2071 6 including include VBG cord-015306-us58wwmp 2071 7 severe severe JJ cord-015306-us58wwmp 2071 8 polyuria polyuria NN cord-015306-us58wwmp 2071 9 ; ; : cord-015306-us58wwmp 2071 10 it -PRON- PRP cord-015306-us58wwmp 2071 11 should should MD cord-015306-us58wwmp 2071 12 be be VB cord-015306-us58wwmp 2071 13 suspected suspect VBN cord-015306-us58wwmp 2071 14 in in IN cord-015306-us58wwmp 2071 15 case case NN cord-015306-us58wwmp 2071 16 of of IN cord-015306-us58wwmp 2071 17 severe severe JJ cord-015306-us58wwmp 2071 18 hypokaliemia hypokaliemia NN cord-015306-us58wwmp 2071 19 even even RB cord-015306-us58wwmp 2071 20 in in IN cord-015306-us58wwmp 2071 21 the the DT cord-015306-us58wwmp 2071 22 absence absence NN cord-015306-us58wwmp 2071 23 of of IN cord-015306-us58wwmp 2071 24 the the DT cord-015306-us58wwmp 2071 25 other other JJ cord-015306-us58wwmp 2071 26 classical classical JJ cord-015306-us58wwmp 2071 27 features feature NNS cord-015306-us58wwmp 2071 28 . . . cord-015306-us58wwmp 2072 1 This this DT cord-015306-us58wwmp 2072 2 case case NN cord-015306-us58wwmp 2072 3 report report NN cord-015306-us58wwmp 2072 4 emphasizes emphasize VBZ cord-015306-us58wwmp 2072 5 the the DT cord-015306-us58wwmp 2072 6 need need NN cord-015306-us58wwmp 2072 7 for for IN cord-015306-us58wwmp 2072 8 repeated repeat VBN cord-015306-us58wwmp 2072 9 laboratory laboratory NN cord-015306-us58wwmp 2072 10 tests test NNS cord-015306-us58wwmp 2072 11 in in IN cord-015306-us58wwmp 2072 12 unclear unclear JJ cord-015306-us58wwmp 2072 13 tubular tubular JJ cord-015306-us58wwmp 2072 14 disorders disorder NNS cord-015306-us58wwmp 2072 15 , , , cord-015306-us58wwmp 2072 16 especially especially RB cord-015306-us58wwmp 2072 17 outside outside RB cord-015306-us58wwmp 2072 18 of of IN cord-015306-us58wwmp 2072 19 confusing confuse VBG cord-015306-us58wwmp 2072 20 intercurrent intercurrent NN cord-015306-us58wwmp 2072 21 illness illness NN cord-015306-us58wwmp 2072 22 . . . cord-015306-us58wwmp 2073 1 A a DT cord-015306-us58wwmp 2073 2 single single JJ cord-015306-us58wwmp 2073 3 basepair basepair NNP cord-015306-us58wwmp 2073 4 mutation mutation NN cord-015306-us58wwmp 2073 5 causes cause VBZ cord-015306-us58wwmp 2073 6 cystinosis cystinosis NNP cord-015306-us58wwmp 2073 7 in in IN cord-015306-us58wwmp 2073 8 the the DT cord-015306-us58wwmp 2073 9 majority majority NN cord-015306-us58wwmp 2073 10 of of IN cord-015306-us58wwmp 2073 11 Western Western NNP cord-015306-us58wwmp 2073 12 Cape Cape NNP cord-015306-us58wwmp 2073 13 patients patient NNS cord-015306-us58wwmp 2073 14 . . . cord-015306-us58wwmp 2074 1 Conclusion conclusion NN cord-015306-us58wwmp 2074 2 : : : cord-015306-us58wwmp 2075 1 RenalTube RenalTube NNP cord-015306-us58wwmp 2075 2 is be VBZ cord-015306-us58wwmp 2075 3 being be VBG cord-015306-us58wwmp 2075 4 used use VBN cord-015306-us58wwmp 2075 5 by by IN cord-015306-us58wwmp 2075 6 pediatric pediatric JJ cord-015306-us58wwmp 2075 7 nephrologists nephrologist NNS cord-015306-us58wwmp 2075 8 over over IN cord-015306-us58wwmp 2075 9 the the DT cord-015306-us58wwmp 2075 10 world world NN cord-015306-us58wwmp 2075 11 for for IN cord-015306-us58wwmp 2075 12 the the DT cord-015306-us58wwmp 2075 13 study study NN cord-015306-us58wwmp 2075 14 of of IN cord-015306-us58wwmp 2075 15 their -PRON- PRP$ cord-015306-us58wwmp 2075 16 patients patient NNS cord-015306-us58wwmp 2075 17 with with IN cord-015306-us58wwmp 2075 18 primary primary JJ cord-015306-us58wwmp 2075 19 tubular tubular JJ cord-015306-us58wwmp 2075 20 disorders disorder NNS cord-015306-us58wwmp 2075 21 . . . cord-015306-us58wwmp 2076 1 RenalTube RenalTube NNP cord-015306-us58wwmp 2076 2 will will MD cord-015306-us58wwmp 2076 3 likely likely RB cord-015306-us58wwmp 2076 4 contribute contribute VB cord-015306-us58wwmp 2076 5 to to IN cord-015306-us58wwmp 2076 6 a a DT cord-015306-us58wwmp 2076 7 better well JJR cord-015306-us58wwmp 2076 8 care care NN cord-015306-us58wwmp 2076 9 of of IN cord-015306-us58wwmp 2076 10 these these DT cord-015306-us58wwmp 2076 11 children child NNS cord-015306-us58wwmp 2076 12 and and CC cord-015306-us58wwmp 2076 13 to to IN cord-015306-us58wwmp 2076 14 a a DT cord-015306-us58wwmp 2076 15 better well RBR cord-015306-us58wwmp 2076 16 scientific scientific JJ cord-015306-us58wwmp 2076 17 understanding understanding NN cord-015306-us58wwmp 2076 18 of of IN cord-015306-us58wwmp 2076 19 primary primary JJ cord-015306-us58wwmp 2076 20 tubular tubular JJ cord-015306-us58wwmp 2076 21 diseases disease NNS cord-015306-us58wwmp 2076 22 . . . cord-015306-us58wwmp 2077 1 The the DT cord-015306-us58wwmp 2077 2 creation creation NN cord-015306-us58wwmp 2077 3 and and CC cord-015306-us58wwmp 2077 4 development development NN cord-015306-us58wwmp 2077 5 of of IN cord-015306-us58wwmp 2077 6 this this DT cord-015306-us58wwmp 2077 7 sort sort NN cord-015306-us58wwmp 2077 8 of of IN cord-015306-us58wwmp 2077 9 international international JJ cord-015306-us58wwmp 2077 10 collaborative collaborative JJ cord-015306-us58wwmp 2077 11 efforts effort NNS cord-015306-us58wwmp 2077 12 must must MD cord-015306-us58wwmp 2077 13 be be VB cord-015306-us58wwmp 2077 14 encouraged encourage VBN cord-015306-us58wwmp 2077 15 within within IN cord-015306-us58wwmp 2077 16 the the DT cord-015306-us58wwmp 2077 17 Pediatric Pediatric NNP cord-015306-us58wwmp 2077 18 Nephrology Nephrology NNP cord-015306-us58wwmp 2077 19 community community NN cord-015306-us58wwmp 2077 20 . . . cord-015306-us58wwmp 2078 1 Objective objective NN cord-015306-us58wwmp 2078 2 : : : cord-015306-us58wwmp 2079 1 To to TO cord-015306-us58wwmp 2079 2 study study VB cord-015306-us58wwmp 2079 3 molecular molecular JJ cord-015306-us58wwmp 2079 4 mechanism mechanism NN cord-015306-us58wwmp 2079 5 of of IN cord-015306-us58wwmp 2079 6 hypercalcemia hypercalcemia NN cord-015306-us58wwmp 2079 7 - - HYPH cord-015306-us58wwmp 2079 8 induced induce VBN cord-015306-us58wwmp 2079 9 nephrogenic nephrogenic JJ cord-015306-us58wwmp 2079 10 diabetes diabetes NN cord-015306-us58wwmp 2079 11 insipidus insipidus NN cord-015306-us58wwmp 2079 12 ( ( -LRB- cord-015306-us58wwmp 2079 13 NDI NDI NNP cord-015306-us58wwmp 2079 14 ) ) -RRB- cord-015306-us58wwmp 2079 15 by by IN cord-015306-us58wwmp 2079 16 identification identification NN cord-015306-us58wwmp 2079 17 of of IN cord-015306-us58wwmp 2079 18 proteins protein NNS cord-015306-us58wwmp 2079 19 in in IN cord-015306-us58wwmp 2079 20 inner inner JJ cord-015306-us58wwmp 2079 21 medullary medullary JJ cord-015306-us58wwmp 2079 22 collecting collecting NN cord-015306-us58wwmp 2079 23 duct duct NN cord-015306-us58wwmp 2079 24 ( ( -LRB- cord-015306-us58wwmp 2079 25 IMCD IMCD NNP cord-015306-us58wwmp 2079 26 ) ) -RRB- cord-015306-us58wwmp 2079 27 responsible responsible JJ cord-015306-us58wwmp 2079 28 for for IN cord-015306-us58wwmp 2079 29 this this DT cord-015306-us58wwmp 2079 30 syndrome syndrome NN cord-015306-us58wwmp 2079 31 . . . cord-015306-us58wwmp 2080 1 Methods method NNS cord-015306-us58wwmp 2080 2 : : : cord-015306-us58wwmp 2081 1 The the DT cord-015306-us58wwmp 2081 2 effect effect NN cord-015306-us58wwmp 2081 3 on on IN cord-015306-us58wwmp 2081 4 rat rat NN cord-015306-us58wwmp 2081 5 kidney kidney NN cord-015306-us58wwmp 2081 6 medullary medullary JJ cord-015306-us58wwmp 2081 7 collecting collect VBG cord-015306-us58wwmp 2081 8 duct duct NN cord-015306-us58wwmp 2081 9 of of IN cord-015306-us58wwmp 2081 10 early early JJ cord-015306-us58wwmp 2081 11 onset onset NN cord-015306-us58wwmp 2081 12 NDI NDI NNP cord-015306-us58wwmp 2081 13 resulting result VBG cord-015306-us58wwmp 2081 14 from from IN cord-015306-us58wwmp 2081 15 parathyroid parathyroid JJ cord-015306-us58wwmp 2081 16 hormone hormone NN cord-015306-us58wwmp 2081 17 - - HYPH cord-015306-us58wwmp 2081 18 induced induce VBN cord-015306-us58wwmp 2081 19 hypercalcemia hypercalcemia NN cord-015306-us58wwmp 2081 20 was be VBD cord-015306-us58wwmp 2081 21 studied study VBN cord-015306-us58wwmp 2081 22 using use VBG cord-015306-us58wwmp 2081 23 proteomics proteomic NNS cord-015306-us58wwmp 2081 24 and and CC cord-015306-us58wwmp 2081 25 phosphoproteomics phosphoproteomic NNS cord-015306-us58wwmp 2081 26 in in IN cord-015306-us58wwmp 2081 27 native native JJ cord-015306-us58wwmp 2081 28 inner inner JJ cord-015306-us58wwmp 2081 29 medullary medullary JJ cord-015306-us58wwmp 2081 30 collecting collecting NN cord-015306-us58wwmp 2081 31 duct duct NN cord-015306-us58wwmp 2081 32 ( ( -LRB- cord-015306-us58wwmp 2081 33 IMCD IMCD NNP cord-015306-us58wwmp 2081 34 ) ) -RRB- cord-015306-us58wwmp 2081 35 cells cell NNS cord-015306-us58wwmp 2081 36 . . . cord-015306-us58wwmp 2082 1 IMCD IMCD NNP cord-015306-us58wwmp 2082 2 tryptic tryptic JJ cord-015306-us58wwmp 2082 3 peptides peptide NNS cord-015306-us58wwmp 2082 4 and and CC cord-015306-us58wwmp 2082 5 phosphopeptides phosphopeptides NNP cord-015306-us58wwmp 2082 6 were be VBD cord-015306-us58wwmp 2082 7 identified identify VBN cord-015306-us58wwmp 2082 8 and and CC cord-015306-us58wwmp 2082 9 quantified quantify VBN cord-015306-us58wwmp 2082 10 by by IN cord-015306-us58wwmp 2082 11 mass mass NN cord-015306-us58wwmp 2082 12 spectrometry spectrometry NN cord-015306-us58wwmp 2082 13 using use VBG cord-015306-us58wwmp 2082 14 a a DT cord-015306-us58wwmp 2082 15 label label NN cord-015306-us58wwmp 2082 16 - - HYPH cord-015306-us58wwmp 2082 17 free free JJ cord-015306-us58wwmp 2082 18 methodology methodology NN cord-015306-us58wwmp 2082 19 . . . cord-015306-us58wwmp 2083 1 The the DT cord-015306-us58wwmp 2083 2 major major JJ cord-015306-us58wwmp 2083 3 findings finding NNS cord-015306-us58wwmp 2083 4 were be VBD cord-015306-us58wwmp 2083 5 confirmed confirm VBN cord-015306-us58wwmp 2083 6 by by IN cord-015306-us58wwmp 2083 7 selected select VBN cord-015306-us58wwmp 2083 8 reaction reaction NN cord-015306-us58wwmp 2083 9 monitoring monitoring NN cord-015306-us58wwmp 2083 10 study study NN cord-015306-us58wwmp 2083 11 , , , cord-015306-us58wwmp 2083 12 immunoblot immunoblot NNP cord-015306-us58wwmp 2083 13 , , , cord-015306-us58wwmp 2083 14 and and CC cord-015306-us58wwmp 2083 15 immunohistochemistry immunohistochemistry NN cord-015306-us58wwmp 2083 16 . . . cord-015306-us58wwmp 2084 1 Results result NNS cord-015306-us58wwmp 2084 2 : : : cord-015306-us58wwmp 2085 1 A a DT cord-015306-us58wwmp 2085 2 total total NN cord-015306-us58wwmp 2085 3 of of IN cord-015306-us58wwmp 2085 4 5,866 5,866 CD cord-015306-us58wwmp 2085 5 peptides peptide NNS cord-015306-us58wwmp 2085 6 corresponding correspond VBG cord-015306-us58wwmp 2085 7 to to IN cord-015306-us58wwmp 2085 8 1,107 1,107 CD cord-015306-us58wwmp 2085 9 proteins protein NNS cord-015306-us58wwmp 2085 10 and and CC cord-015306-us58wwmp 2085 11 1,388 1,388 CD cord-015306-us58wwmp 2085 12 phosphopeptides phosphopeptide NNS cord-015306-us58wwmp 2085 13 of of IN cord-015306-us58wwmp 2085 14 580 580 CD cord-015306-us58wwmp 2085 15 proteins protein NNS cord-015306-us58wwmp 2085 16 were be VBD cord-015306-us58wwmp 2085 17 identified identify VBN cord-015306-us58wwmp 2085 18 , , , cord-015306-us58wwmp 2085 19 with with IN cord-015306-us58wwmp 2085 20 significant significant JJ cord-015306-us58wwmp 2085 21 changes change NNS cord-015306-us58wwmp 2085 22 in in IN cord-015306-us58wwmp 2085 23 abundance abundance NN cord-015306-us58wwmp 2085 24 of of IN cord-015306-us58wwmp 2085 25 69 69 CD cord-015306-us58wwmp 2085 26 proteins protein NNS cord-015306-us58wwmp 2085 27 and and CC cord-015306-us58wwmp 2085 28 49 49 CD cord-015306-us58wwmp 2085 29 phosphopeptides phosphopeptide NNS cord-015306-us58wwmp 2085 30 in in IN cord-015306-us58wwmp 2085 31 early early JJ cord-015306-us58wwmp 2085 32 onset onset NN cord-015306-us58wwmp 2085 33 NDI NDI NNP cord-015306-us58wwmp 2085 34 versus versus IN cord-015306-us58wwmp 2085 35 vehicle vehicle NN cord-015306-us58wwmp 2085 36 controls control NNS cord-015306-us58wwmp 2085 37 . . . cord-015306-us58wwmp 2086 1 Gene Gene NNP cord-015306-us58wwmp 2086 2 Ontology Ontology NNP cord-015306-us58wwmp 2086 3 terms term NNS cord-015306-us58wwmp 2086 4 and and CC cord-015306-us58wwmp 2086 5 pathway pathway NN cord-015306-us58wwmp 2086 6 analysis analysis NN cord-015306-us58wwmp 2086 7 revealed reveal VBD cord-015306-us58wwmp 2086 8 that that IN cord-015306-us58wwmp 2086 9 hypercalcemiaaffected hypercalcemiaaffecte VBN cord-015306-us58wwmp 2086 10 proteins protein NNS cord-015306-us58wwmp 2086 11 and and CC cord-015306-us58wwmp 2086 12 phosphoproteins phosphoprotein NNS cord-015306-us58wwmp 2086 13 are be VBP cord-015306-us58wwmp 2086 14 associated associate VBN cord-015306-us58wwmp 2086 15 with with IN cord-015306-us58wwmp 2086 16 integrin integrin NN cord-015306-us58wwmp 2086 17 signaling signaling NN cord-015306-us58wwmp 2086 18 , , , cord-015306-us58wwmp 2086 19 and and CC cord-015306-us58wwmp 2086 20 actin actin NNP cord-015306-us58wwmp 2086 21 cytoskeleton cytoskeleton NN cord-015306-us58wwmp 2086 22 organization organization NN cord-015306-us58wwmp 2086 23 . . . cord-015306-us58wwmp 2087 1 Immunoblot Immunoblot NNP cord-015306-us58wwmp 2087 2 and and CC cord-015306-us58wwmp 2087 3 selected select VBN cord-015306-us58wwmp 2087 4 reaction reaction NN cord-015306-us58wwmp 2087 5 monitoring monitor VBG cord-015306-us58wwmp 2087 6 LC LC NNP cord-015306-us58wwmp 2087 7 - - HYPH cord-015306-us58wwmp 2087 8 MS MS NNP cord-015306-us58wwmp 2087 9 / / SYM cord-015306-us58wwmp 2087 10 MS MS NNP cord-015306-us58wwmp 2087 11 studies study NNS cord-015306-us58wwmp 2087 12 confirmed confirm VBD cord-015306-us58wwmp 2087 13 the the DT cord-015306-us58wwmp 2087 14 hypercalcemia hypercalcemia NN cord-015306-us58wwmp 2087 15 - - HYPH cord-015306-us58wwmp 2087 16 regulated regulate VBN cord-015306-us58wwmp 2087 17 proteins protein NNS cord-015306-us58wwmp 2087 18 ( ( -LRB- cord-015306-us58wwmp 2087 19 Agrin Agrin NNP cord-015306-us58wwmp 2087 20 , , , cord-015306-us58wwmp 2087 21 Arcp1b arcp1b NN cord-015306-us58wwmp 2087 22 , , , cord-015306-us58wwmp 2087 23 Capg Capg NNP cord-015306-us58wwmp 2087 24 , , , cord-015306-us58wwmp 2087 25 ERM ERM NNP cord-015306-us58wwmp 2087 26 , , , cord-015306-us58wwmp 2087 27 Itgb1 Itgb1 NNP cord-015306-us58wwmp 2087 28 , , , cord-015306-us58wwmp 2087 29 Lamb2 Lamb2 NNP cord-015306-us58wwmp 2087 30 , , , cord-015306-us58wwmp 2087 31 and and CC cord-015306-us58wwmp 2087 32 Lamc1 lamc1 JJ cord-015306-us58wwmp 2087 33 ) ) -RRB- cord-015306-us58wwmp 2088 1 and and CC cord-015306-us58wwmp 2088 2 phosphoproteins phosphoproteins NNP cord-015306-us58wwmp 2088 3 ( ( -LRB- cord-015306-us58wwmp 2088 4 Myh9 Myh9 NNP cord-015306-us58wwmp 2088 5 , , , cord-015306-us58wwmp 2088 6 Add1 Add1 NNP cord-015306-us58wwmp 2088 7 , , , cord-015306-us58wwmp 2088 8 Dync1li1 dync1li1 NN cord-015306-us58wwmp 2088 9 , , , cord-015306-us58wwmp 2088 10 Cgnl1 cgnl1 JJ cord-015306-us58wwmp 2088 11 , , , cord-015306-us58wwmp 2088 12 Aqp2 Aqp2 NNP cord-015306-us58wwmp 2088 13 ) ) -RRB- cord-015306-us58wwmp 2088 14 . . . cord-015306-us58wwmp 2089 1 Hypercalcemia hypercalcemia NN cord-015306-us58wwmp 2089 2 induced induce VBD cord-015306-us58wwmp 2089 3 changes change NNS cord-015306-us58wwmp 2089 4 in in IN cord-015306-us58wwmp 2089 5 abundance abundance NN cord-015306-us58wwmp 2089 6 of of IN cord-015306-us58wwmp 2089 7 vasopressin vasopressin NN cord-015306-us58wwmp 2089 8 - - HYPH cord-015306-us58wwmp 2089 9 regulated regulate VBN cord-015306-us58wwmp 2089 10 phosphorylation phosphorylation NN cord-015306-us58wwmp 2089 11 of of IN cord-015306-us58wwmp 2089 12 aquaporin-2 aquaporin-2 NNP cord-015306-us58wwmp 2090 1 ( ( -LRB- cord-015306-us58wwmp 2090 2 Aqp2 Aqp2 NNP cord-015306-us58wwmp 2090 3 ) ) -RRB- cord-015306-us58wwmp 2090 4 at at IN cord-015306-us58wwmp 2090 5 Ser256 ser256 CD cord-015306-us58wwmp 2090 6 and and CC cord-015306-us58wwmp 2090 7 Ser261 Ser261 NNS cord-015306-us58wwmp 2090 8 , , , cord-015306-us58wwmp 2090 9 but but CC cord-015306-us58wwmp 2090 10 not not RB cord-015306-us58wwmp 2090 11 total total JJ cord-015306-us58wwmp 2090 12 Aqp2 Aqp2 NNP cord-015306-us58wwmp 2090 13 , , , cord-015306-us58wwmp 2090 14 and and CC cord-015306-us58wwmp 2090 15 decreased decrease VBD cord-015306-us58wwmp 2090 16 abundances abundance NNS cord-015306-us58wwmp 2090 17 of of IN cord-015306-us58wwmp 2090 18 Slc14a2 slc14a2 NN cord-015306-us58wwmp 2090 19 urea urea NN cord-015306-us58wwmp 2090 20 transporters transporter NNS cord-015306-us58wwmp 2090 21 UT UT NNP cord-015306-us58wwmp 2090 22 - - HYPH cord-015306-us58wwmp 2090 23 A1 A1 NNP cord-015306-us58wwmp 2090 24 , , , cord-015306-us58wwmp 2090 25 UT UT NNP cord-015306-us58wwmp 2090 26 - - HYPH cord-015306-us58wwmp 2090 27 A3 A3 NNP cord-015306-us58wwmp 2090 28 , , , cord-015306-us58wwmp 2090 29 and and CC cord-015306-us58wwmp 2090 30 phospho phospho NN cord-015306-us58wwmp 2090 31 - - HYPH cord-015306-us58wwmp 2090 32 Ser486-UT Ser486-UT NNP cord-015306-us58wwmp 2090 33 - - HYPH cord-015306-us58wwmp 2090 34 A1 A1 NNP cord-015306-us58wwmp 2090 35 . . . cord-015306-us58wwmp 2091 1 The the DT cord-015306-us58wwmp 2091 2 major major JJ cord-015306-us58wwmp 2091 3 findings finding NNS cord-015306-us58wwmp 2091 4 were be VBD cord-015306-us58wwmp 2091 5 also also RB cord-015306-us58wwmp 2091 6 identified identify VBN cord-015306-us58wwmp 2091 7 in in IN cord-015306-us58wwmp 2091 8 IMCD IMCD NNP cord-015306-us58wwmp 2091 9 of of IN cord-015306-us58wwmp 2091 10 rats rat NNS cord-015306-us58wwmp 2091 11 with with IN cord-015306-us58wwmp 2091 12 vitamin vitamin NN cord-015306-us58wwmp 2091 13 D d NN cord-015306-us58wwmp 2091 14 - - HYPH cord-015306-us58wwmp 2091 15 induced induce VBN cord-015306-us58wwmp 2091 16 hypercalcemia hypercalcemia NN cord-015306-us58wwmp 2091 17 . . . cord-015306-us58wwmp 2092 1 Filamentous filamentous JJ cord-015306-us58wwmp 2092 2 actin actin NN cord-015306-us58wwmp 2092 3 aggregation aggregation NN cord-015306-us58wwmp 2092 4 was be VBD cord-015306-us58wwmp 2092 5 firstly firstly RB cord-015306-us58wwmp 2092 6 demonstrated demonstrate VBN cord-015306-us58wwmp 2092 7 in in IN cord-015306-us58wwmp 2092 8 IMCD IMCD NNP cord-015306-us58wwmp 2092 9 of of IN cord-015306-us58wwmp 2092 10 rats rat NNS cord-015306-us58wwmp 2092 11 with with IN cord-015306-us58wwmp 2092 12 hypercalcemia hypercalcemia NN cord-015306-us58wwmp 2092 13 - - HYPH cord-015306-us58wwmp 2092 14 induced induce VBN cord-015306-us58wwmp 2092 15 NDI NDI NNP cord-015306-us58wwmp 2092 16 from from IN cord-015306-us58wwmp 2092 17 both both DT cord-015306-us58wwmp 2092 18 PTH PTH NNP cord-015306-us58wwmp 2092 19 and and CC cord-015306-us58wwmp 2092 20 vitamin vitamin NN cord-015306-us58wwmp 2092 21 D. D. NNP cord-015306-us58wwmp 2092 22 Conclusions Conclusions NNPS cord-015306-us58wwmp 2092 23 : : : cord-015306-us58wwmp 2092 24 Early early RB cord-015306-us58wwmp 2092 25 increasing increase VBG cord-015306-us58wwmp 2092 26 in in IN cord-015306-us58wwmp 2092 27 water water NN cord-015306-us58wwmp 2092 28 excretion excretion NN cord-015306-us58wwmp 2092 29 in in IN cord-015306-us58wwmp 2092 30 response response NN cord-015306-us58wwmp 2092 31 to to IN cord-015306-us58wwmp 2092 32 hypercalcemia hypercalcemia NN cord-015306-us58wwmp 2092 33 are be VBP cord-015306-us58wwmp 2092 34 dependent dependent JJ cord-015306-us58wwmp 2092 35 of of IN cord-015306-us58wwmp 2092 36 changes change NNS cord-015306-us58wwmp 2092 37 in in IN cord-015306-us58wwmp 2092 38 abundances abundance NNS cord-015306-us58wwmp 2092 39 of of IN cord-015306-us58wwmp 2092 40 Aqp2 aqp2 JJ cord-015306-us58wwmp 2092 41 phosphorylations phosphorylation NNS cord-015306-us58wwmp 2092 42 , , , cord-015306-us58wwmp 2092 43 UT UT NNP cord-015306-us58wwmp 2092 44 - - HYPH cord-015306-us58wwmp 2092 45 A A NNP cord-015306-us58wwmp 2092 46 and and CC cord-015306-us58wwmp 2092 47 its -PRON- PRP$ cord-015306-us58wwmp 2092 48 phosphorylations phosphorylation NNS cord-015306-us58wwmp 2092 49 are be VBP cord-015306-us58wwmp 2092 50 consistent consistent JJ cord-015306-us58wwmp 2092 51 with with IN cord-015306-us58wwmp 2092 52 prior prior JJ cord-015306-us58wwmp 2092 53 literature literature NN cord-015306-us58wwmp 2092 54 pointing point VBG cord-015306-us58wwmp 2092 55 to to IN cord-015306-us58wwmp 2092 56 key key JJ cord-015306-us58wwmp 2092 57 roles role NNS cord-015306-us58wwmp 2092 58 of of IN cord-015306-us58wwmp 2092 59 the the DT cord-015306-us58wwmp 2092 60 integrin integrin NN cord-015306-us58wwmp 2092 61 signaling signal VBG cord-015306-us58wwmp 2092 62 and and CC cord-015306-us58wwmp 2092 63 the the DT cord-015306-us58wwmp 2092 64 actin actin NN cord-015306-us58wwmp 2092 65 cytoskeleton cytoskeleton NN cord-015306-us58wwmp 2092 66 in in IN cord-015306-us58wwmp 2092 67 maintenance maintenance NN cord-015306-us58wwmp 2092 68 of of IN cord-015306-us58wwmp 2092 69 collecting collect VBG cord-015306-us58wwmp 2092 70 duct duct NN cord-015306-us58wwmp 2092 71 function function NN cord-015306-us58wwmp 2092 72 . . . cord-015306-us58wwmp 2093 1 Objective objective NN cord-015306-us58wwmp 2093 2 : : : cord-015306-us58wwmp 2094 1 To to TO cord-015306-us58wwmp 2094 2 study study VB cord-015306-us58wwmp 2094 3 molecular molecular JJ cord-015306-us58wwmp 2094 4 mechanism mechanism NN cord-015306-us58wwmp 2094 5 of of IN cord-015306-us58wwmp 2094 6 hypokalemia hypokalemia NN cord-015306-us58wwmp 2094 7 - - HYPH cord-015306-us58wwmp 2094 8 induced induce VBN cord-015306-us58wwmp 2094 9 nephrogenic nephrogenic JJ cord-015306-us58wwmp 2094 10 diabetes diabetes NN cord-015306-us58wwmp 2094 11 insipidus insipidus NN cord-015306-us58wwmp 2094 12 ( ( -LRB- cord-015306-us58wwmp 2094 13 NDI NDI NNP cord-015306-us58wwmp 2094 14 ) ) -RRB- cord-015306-us58wwmp 2094 15 by by IN cord-015306-us58wwmp 2094 16 identification identification NN cord-015306-us58wwmp 2094 17 of of IN cord-015306-us58wwmp 2094 18 proteins protein NNS cord-015306-us58wwmp 2094 19 in in IN cord-015306-us58wwmp 2094 20 inner inner JJ cord-015306-us58wwmp 2094 21 medullary medullary JJ cord-015306-us58wwmp 2094 22 collecting collecting NN cord-015306-us58wwmp 2094 23 duct duct NN cord-015306-us58wwmp 2094 24 ( ( -LRB- cord-015306-us58wwmp 2094 25 IMCD IMCD NNP cord-015306-us58wwmp 2094 26 ) ) -RRB- cord-015306-us58wwmp 2094 27 responsible responsible JJ cord-015306-us58wwmp 2094 28 for for IN cord-015306-us58wwmp 2094 29 this this DT cord-015306-us58wwmp 2094 30 syndrome syndrome NN cord-015306-us58wwmp 2094 31 . . . cord-015306-us58wwmp 2095 1 Methods method NNS cord-015306-us58wwmp 2095 2 : : : cord-015306-us58wwmp 2096 1 The the DT cord-015306-us58wwmp 2096 2 effect effect NN cord-015306-us58wwmp 2096 3 on on IN cord-015306-us58wwmp 2096 4 rat rat NN cord-015306-us58wwmp 2096 5 kidney kidney NN cord-015306-us58wwmp 2096 6 medullary medullary JJ cord-015306-us58wwmp 2096 7 collecting collect VBG cord-015306-us58wwmp 2096 8 duct duct NN cord-015306-us58wwmp 2096 9 of of IN cord-015306-us58wwmp 2096 10 early early JJ cord-015306-us58wwmp 2096 11 onset onset NN cord-015306-us58wwmp 2096 12 NDI NDI NNP cord-015306-us58wwmp 2096 13 resulting result VBG cord-015306-us58wwmp 2096 14 from from IN cord-015306-us58wwmp 2096 15 hypokalemia hypokalemia NN cord-015306-us58wwmp 2096 16 was be VBD cord-015306-us58wwmp 2096 17 studied study VBN cord-015306-us58wwmp 2096 18 using use VBG cord-015306-us58wwmp 2096 19 proteomics proteomic NNS cord-015306-us58wwmp 2096 20 in in IN cord-015306-us58wwmp 2096 21 native native JJ cord-015306-us58wwmp 2096 22 inner inner JJ cord-015306-us58wwmp 2096 23 medullary medullary JJ cord-015306-us58wwmp 2096 24 collecting collecting NN cord-015306-us58wwmp 2096 25 duct duct NN cord-015306-us58wwmp 2096 26 ( ( -LRB- cord-015306-us58wwmp 2096 27 IMCD IMCD NNP cord-015306-us58wwmp 2096 28 ) ) -RRB- cord-015306-us58wwmp 2096 29 cells cell NNS cord-015306-us58wwmp 2096 30 . . . cord-015306-us58wwmp 2097 1 IMCD IMCD NNP cord-015306-us58wwmp 2097 2 tryptic tryptic JJ cord-015306-us58wwmp 2097 3 peptides peptide NNS cord-015306-us58wwmp 2097 4 were be VBD cord-015306-us58wwmp 2097 5 identified identify VBN cord-015306-us58wwmp 2097 6 and and CC cord-015306-us58wwmp 2097 7 quantified quantify VBN cord-015306-us58wwmp 2097 8 by by IN cord-015306-us58wwmp 2097 9 mass mass NN cord-015306-us58wwmp 2097 10 spectrometry spectrometry NN cord-015306-us58wwmp 2097 11 using use VBG cord-015306-us58wwmp 2097 12 a a DT cord-015306-us58wwmp 2097 13 label label NN cord-015306-us58wwmp 2097 14 - - HYPH cord-015306-us58wwmp 2097 15 free free JJ cord-015306-us58wwmp 2097 16 methodology methodology NN cord-015306-us58wwmp 2097 17 . . . cord-015306-us58wwmp 2098 1 The the DT cord-015306-us58wwmp 2098 2 major major JJ cord-015306-us58wwmp 2098 3 findings finding NNS cord-015306-us58wwmp 2098 4 were be VBD cord-015306-us58wwmp 2098 5 confirmed confirm VBN cord-015306-us58wwmp 2098 6 by by IN cord-015306-us58wwmp 2098 7 selected select VBN cord-015306-us58wwmp 2098 8 reaction reaction NN cord-015306-us58wwmp 2098 9 monitoring monitoring NN cord-015306-us58wwmp 2098 10 study study NN cord-015306-us58wwmp 2098 11 , , , cord-015306-us58wwmp 2098 12 immunoblot immunoblot NNP cord-015306-us58wwmp 2098 13 and and CC cord-015306-us58wwmp 2098 14 immunohistochemistry immunohistochemistry NN cord-015306-us58wwmp 2098 15 . . . cord-015306-us58wwmp 2099 1 Results result NNS cord-015306-us58wwmp 2099 2 : : : cord-015306-us58wwmp 2100 1 A a DT cord-015306-us58wwmp 2100 2 total total NN cord-015306-us58wwmp 2100 3 of of IN cord-015306-us58wwmp 2100 4 2,477 2,477 CD cord-015306-us58wwmp 2100 5 peptides peptide NNS cord-015306-us58wwmp 2100 6 corresponding correspond VBG cord-015306-us58wwmp 2100 7 to to IN cord-015306-us58wwmp 2100 8 821 821 CD cord-015306-us58wwmp 2100 9 proteins protein NNS cord-015306-us58wwmp 2100 10 were be VBD cord-015306-us58wwmp 2100 11 identified identify VBN cord-015306-us58wwmp 2100 12 with with IN cord-015306-us58wwmp 2100 13 significant significant JJ cord-015306-us58wwmp 2100 14 changes change NNS cord-015306-us58wwmp 2100 15 in in IN cord-015306-us58wwmp 2100 16 abundance abundance NN cord-015306-us58wwmp 2100 17 of of IN cord-015306-us58wwmp 2100 18 189 189 CD cord-015306-us58wwmp 2100 19 proteins protein NNS cord-015306-us58wwmp 2100 20 in in IN cord-015306-us58wwmp 2100 21 early early JJ cord-015306-us58wwmp 2100 22 onset onset NN cord-015306-us58wwmp 2100 23 NDI NDI NNP cord-015306-us58wwmp 2100 24 versus versus IN cord-015306-us58wwmp 2100 25 vehicle vehicle NN cord-015306-us58wwmp 2100 26 controls control NNS cord-015306-us58wwmp 2100 27 . . . cord-015306-us58wwmp 2101 1 Gene Gene NNP cord-015306-us58wwmp 2101 2 Ontology Ontology NNP cord-015306-us58wwmp 2101 3 terms term NNS cord-015306-us58wwmp 2101 4 and and CC cord-015306-us58wwmp 2101 5 pathway pathway NN cord-015306-us58wwmp 2101 6 analysis analysis NN cord-015306-us58wwmp 2101 7 revealed reveal VBD cord-015306-us58wwmp 2101 8 that that IN cord-015306-us58wwmp 2101 9 hypokalemia hypokalemia NN cord-015306-us58wwmp 2101 10 - - HYPH cord-015306-us58wwmp 2101 11 affected affect VBN cord-015306-us58wwmp 2101 12 proteins protein NNS cord-015306-us58wwmp 2101 13 are be VBP cord-015306-us58wwmp 2101 14 associated associate VBN cord-015306-us58wwmp 2101 15 with with IN cord-015306-us58wwmp 2101 16 generation generation NN cord-015306-us58wwmp 2101 17 of of IN cord-015306-us58wwmp 2101 18 precursor precursor NN cord-015306-us58wwmp 2101 19 metabolite metabolite NN cord-015306-us58wwmp 2101 20 and and CC cord-015306-us58wwmp 2101 21 energy energy NN cord-015306-us58wwmp 2101 22 and and CC cord-015306-us58wwmp 2101 23 regulation regulation NN cord-015306-us58wwmp 2101 24 of of IN cord-015306-us58wwmp 2101 25 actin actin NN cord-015306-us58wwmp 2101 26 cytoskeleton cytoskeleton NN cord-015306-us58wwmp 2101 27 . . . cord-015306-us58wwmp 2102 1 Immunoblot Immunoblot NNP cord-015306-us58wwmp 2102 2 and and CC cord-015306-us58wwmp 2102 3 selected select VBN cord-015306-us58wwmp 2102 4 reaction reaction NN cord-015306-us58wwmp 2102 5 Objective Objective NNP cord-015306-us58wwmp 2102 6 : : : cord-015306-us58wwmp 2103 1 Inherited inherit VBN cord-015306-us58wwmp 2103 2 distal distal JJ cord-015306-us58wwmp 2103 3 RTA RTA NNP cord-015306-us58wwmp 2103 4 ( ( -LRB- cord-015306-us58wwmp 2103 5 dRTA dRTA NNP cord-015306-us58wwmp 2103 6 ) ) -RRB- cord-015306-us58wwmp 2103 7 is be VBZ cord-015306-us58wwmp 2103 8 a a DT cord-015306-us58wwmp 2103 9 rare rare JJ cord-015306-us58wwmp 2103 10 condition condition NN cord-015306-us58wwmp 2103 11 and and CC cord-015306-us58wwmp 2103 12 is be VBZ cord-015306-us58wwmp 2103 13 almost almost RB cord-015306-us58wwmp 2103 14 always always RB cord-015306-us58wwmp 2103 15 observed observe VBN cord-015306-us58wwmp 2103 16 in in IN cord-015306-us58wwmp 2103 17 children child NNS cord-015306-us58wwmp 2103 18 as as IN cord-015306-us58wwmp 2103 19 a a DT cord-015306-us58wwmp 2103 20 primary primary JJ cord-015306-us58wwmp 2103 21 entity entity NN cord-015306-us58wwmp 2103 22 . . . cord-015306-us58wwmp 2104 1 Mutations mutation NNS cord-015306-us58wwmp 2104 2 in in IN cord-015306-us58wwmp 2104 3 genes gene NNS cord-015306-us58wwmp 2104 4 encoding encode VBG cord-015306-us58wwmp 2104 5 transporter transporter NN cord-015306-us58wwmp 2104 6 or or CC cord-015306-us58wwmp 2104 7 channel channel NN cord-015306-us58wwmp 2104 8 proteins protein NNS cord-015306-us58wwmp 2104 9 operating operate VBG cord-015306-us58wwmp 2104 10 along along IN cord-015306-us58wwmp 2104 11 the the DT cord-015306-us58wwmp 2104 12 renal renal JJ cord-015306-us58wwmp 2104 13 tubule tubule NN cord-015306-us58wwmp 2104 14 may may MD cord-015306-us58wwmp 2104 15 result result VB cord-015306-us58wwmp 2104 16 in in IN cord-015306-us58wwmp 2104 17 a a DT cord-015306-us58wwmp 2104 18 variety variety NN cord-015306-us58wwmp 2104 19 of of IN cord-015306-us58wwmp 2104 20 functional functional JJ cord-015306-us58wwmp 2104 21 defects defect NNS cord-015306-us58wwmp 2104 22 . . . cord-015306-us58wwmp 2105 1 The the DT cord-015306-us58wwmp 2105 2 identification identification NN cord-015306-us58wwmp 2105 3 of of IN cord-015306-us58wwmp 2105 4 the the DT cord-015306-us58wwmp 2105 5 molecular molecular JJ cord-015306-us58wwmp 2105 6 defects defect NNS cord-015306-us58wwmp 2105 7 in in IN cord-015306-us58wwmp 2105 8 dRTA dRTA NNP cord-015306-us58wwmp 2105 9 may may MD cord-015306-us58wwmp 2105 10 provide provide VB cord-015306-us58wwmp 2105 11 a a DT cord-015306-us58wwmp 2105 12 basis basis NN cord-015306-us58wwmp 2105 13 for for IN cord-015306-us58wwmp 2105 14 future future JJ cord-015306-us58wwmp 2105 15 design design NN cord-015306-us58wwmp 2105 16 of of IN cord-015306-us58wwmp 2105 17 targeted target VBN cord-015306-us58wwmp 2105 18 therapeutic therapeutic JJ cord-015306-us58wwmp 2105 19 interventions intervention NNS cord-015306-us58wwmp 2105 20 and and CC cord-015306-us58wwmp 2105 21 , , , cord-015306-us58wwmp 2105 22 possibly possibly RB cord-015306-us58wwmp 2105 23 , , , cord-015306-us58wwmp 2105 24 strategies strategy NNS cord-015306-us58wwmp 2105 25 for for IN cord-015306-us58wwmp 2105 26 gene gene NN cord-015306-us58wwmp 2105 27 therapy therapy NN cord-015306-us58wwmp 2105 28 of of IN cord-015306-us58wwmp 2105 29 these these DT cord-015306-us58wwmp 2105 30 complex complex JJ cord-015306-us58wwmp 2105 31 disorders disorder NNS cord-015306-us58wwmp 2105 32 . . . cord-015306-us58wwmp 2106 1 For for IN cord-015306-us58wwmp 2106 2 this this DT cord-015306-us58wwmp 2106 3 reason reason NN cord-015306-us58wwmp 2106 4 , , , cord-015306-us58wwmp 2106 5 we -PRON- PRP cord-015306-us58wwmp 2106 6 evaluated evaluate VBD cord-015306-us58wwmp 2106 7 mutations mutation NNS cord-015306-us58wwmp 2106 8 in in IN cord-015306-us58wwmp 2106 9 SLC4A1 SLC4A1 NNP cord-015306-us58wwmp 2106 10 and and CC cord-015306-us58wwmp 2106 11 ATP6V1B1 ATP6V1B1 NNP cord-015306-us58wwmp 2106 12 genes gene NNS cord-015306-us58wwmp 2106 13 . . . cord-015306-us58wwmp 2107 1 Methods method NNS cord-015306-us58wwmp 2107 2 Genomic genomic VBP cord-015306-us58wwmp 2107 3 DNA dna NN cord-015306-us58wwmp 2107 4 from from IN cord-015306-us58wwmp 2107 5 20 20 CD cord-015306-us58wwmp 2107 6 pediatric pediatric JJ cord-015306-us58wwmp 2107 7 patients patient NNS cord-015306-us58wwmp 2107 8 diagnosed diagnose VBN cord-015306-us58wwmp 2107 9 with with IN cord-015306-us58wwmp 2107 10 dRTA dRTA NNP cord-015306-us58wwmp 2107 11 was be VBD cord-015306-us58wwmp 2107 12 extracted extract VBN cord-015306-us58wwmp 2107 13 from from IN cord-015306-us58wwmp 2107 14 peripheral peripheral JJ cord-015306-us58wwmp 2107 15 blood blood NN cord-015306-us58wwmp 2107 16 samples sample NNS cord-015306-us58wwmp 2107 17 . . . cord-015306-us58wwmp 2108 1 Sequencing sequencing NN cord-015306-us58wwmp 2108 2 was be VBD cord-015306-us58wwmp 2108 3 performed perform VBN cord-015306-us58wwmp 2108 4 for for IN cord-015306-us58wwmp 2108 5 five five CD cord-015306-us58wwmp 2108 6 exons exon NNS cord-015306-us58wwmp 2108 7 of of IN cord-015306-us58wwmp 2108 8 SLC4A1 SLC4A1 NNP cord-015306-us58wwmp 2108 9 ( ( -LRB- cord-015306-us58wwmp 2108 10 14 14 CD cord-015306-us58wwmp 2108 11 , , , cord-015306-us58wwmp 2108 12 15 15 CD cord-015306-us58wwmp 2108 13 , , , cord-015306-us58wwmp 2108 14 17 17 CD cord-015306-us58wwmp 2108 15 , , , cord-015306-us58wwmp 2108 16 19 19 CD cord-015306-us58wwmp 2108 17 , , , cord-015306-us58wwmp 2108 18 20 20 CD cord-015306-us58wwmp 2108 19 ) ) -RRB- cord-015306-us58wwmp 2108 20 and and CC cord-015306-us58wwmp 2108 21 two two CD cord-015306-us58wwmp 2108 22 exons exon NNS cord-015306-us58wwmp 2108 23 of of IN cord-015306-us58wwmp 2108 24 ATP6V1B1 ATP6V1B1 NNP cord-015306-us58wwmp 2108 25 ( ( -LRB- cord-015306-us58wwmp 2108 26 1 1 CD cord-015306-us58wwmp 2108 27 , , , cord-015306-us58wwmp 2108 28 7 7 CD cord-015306-us58wwmp 2108 29 ) ) -RRB- cord-015306-us58wwmp 2108 30 . . . cord-015306-us58wwmp 2109 1 All all PDT cord-015306-us58wwmp 2109 2 the the DT cord-015306-us58wwmp 2109 3 selected select VBN cord-015306-us58wwmp 2109 4 exons exon NNS cord-015306-us58wwmp 2109 5 are be VBP cord-015306-us58wwmp 2109 6 considered consider VBN cord-015306-us58wwmp 2109 7 hotspots hotspot NNS cord-015306-us58wwmp 2109 8 for for IN cord-015306-us58wwmp 2109 9 mutations mutation NNS cord-015306-us58wwmp 2109 10 associated associate VBN cord-015306-us58wwmp 2109 11 to to IN cord-015306-us58wwmp 2109 12 this this DT cord-015306-us58wwmp 2109 13 tubular tubular JJ cord-015306-us58wwmp 2109 14 disorder disorder NN cord-015306-us58wwmp 2109 15 . . . cord-015306-us58wwmp 2110 1 Results result NNS cord-015306-us58wwmp 2111 1 Silent silent JJ cord-015306-us58wwmp 2111 2 mutations mutation NNS cord-015306-us58wwmp 2111 3 were be VBD cord-015306-us58wwmp 2111 4 identified identify VBN cord-015306-us58wwmp 2111 5 in in IN cord-015306-us58wwmp 2111 6 both both CC cord-015306-us58wwmp 2111 7 studied study VBN cord-015306-us58wwmp 2111 8 genes gene NNS cord-015306-us58wwmp 2111 9 . . . cord-015306-us58wwmp 2112 1 The the DT cord-015306-us58wwmp 2112 2 mutation mutation NN cord-015306-us58wwmp 2112 3 c.2688 c.2688 NN cord-015306-us58wwmp 2112 4 T t NN cord-015306-us58wwmp 2112 5 > > XX cord-015306-us58wwmp 2113 1 C C NNP cord-015306-us58wwmp 2113 2 was be VBD cord-015306-us58wwmp 2113 3 identified identify VBN cord-015306-us58wwmp 2113 4 in in IN cord-015306-us58wwmp 2113 5 exon exon NN cord-015306-us58wwmp 2113 6 20 20 CD cord-015306-us58wwmp 2113 7 of of IN cord-015306-us58wwmp 2113 8 SLC4A1 SLC4A1 NNP cord-015306-us58wwmp 2113 9 in in IN cord-015306-us58wwmp 2113 10 one one CD cord-015306-us58wwmp 2113 11 patient patient NN cord-015306-us58wwmp 2113 12 and and CC cord-015306-us58wwmp 2113 13 the the DT cord-015306-us58wwmp 2113 14 second second JJ cord-015306-us58wwmp 2113 15 variation variation NN cord-015306-us58wwmp 2113 16 ( ( -LRB- cord-015306-us58wwmp 2113 17 c.27T c.27t NN cord-015306-us58wwmp 2113 18 > > XX cord-015306-us58wwmp 2113 19 C C NNP cord-015306-us58wwmp 2113 20 ) ) -RRB- cord-015306-us58wwmp 2113 21 was be VBD cord-015306-us58wwmp 2113 22 found find VBN cord-015306-us58wwmp 2113 23 in in IN cord-015306-us58wwmp 2113 24 exon exon NN cord-015306-us58wwmp 2113 25 1 1 CD cord-015306-us58wwmp 2113 26 of of IN cord-015306-us58wwmp 2113 27 ATP6V1B1 ATP6V1B1 NNP cord-015306-us58wwmp 2113 28 in in IN cord-015306-us58wwmp 2113 29 two two CD cord-015306-us58wwmp 2113 30 patients patient NNS cord-015306-us58wwmp 2113 31 . . . cord-015306-us58wwmp 2114 1 Although although IN cord-015306-us58wwmp 2114 2 previously previously RB cord-015306-us58wwmp 2114 3 described describe VBN cord-015306-us58wwmp 2114 4 , , , cord-015306-us58wwmp 2114 5 these these DT cord-015306-us58wwmp 2114 6 silent silent JJ cord-015306-us58wwmp 2114 7 variations variation NNS cord-015306-us58wwmp 2114 8 are be VBP cord-015306-us58wwmp 2114 9 not not RB cord-015306-us58wwmp 2114 10 highly highly RB cord-015306-us58wwmp 2114 11 frequent frequent JJ cord-015306-us58wwmp 2114 12 in in IN cord-015306-us58wwmp 2114 13 the the DT cord-015306-us58wwmp 2114 14 overall overall JJ cord-015306-us58wwmp 2114 15 population population NN cord-015306-us58wwmp 2114 16 . . . cord-015306-us58wwmp 2115 1 Also also RB cord-015306-us58wwmp 2115 2 in in IN cord-015306-us58wwmp 2115 3 SLC4A1 SLC4A1 NNP cord-015306-us58wwmp 2115 4 , , , cord-015306-us58wwmp 2115 5 exon exon NN cord-015306-us58wwmp 2115 6 19 19 CD cord-015306-us58wwmp 2115 7 , , , cord-015306-us58wwmp 2115 8 two two CD cord-015306-us58wwmp 2115 9 nonsynonymous nonsynonymous JJ cord-015306-us58wwmp 2115 10 variations variation NNS cord-015306-us58wwmp 2115 11 were be VBD cord-015306-us58wwmp 2115 12 identified identify VBN cord-015306-us58wwmp 2115 13 in in IN cord-015306-us58wwmp 2115 14 the the DT cord-015306-us58wwmp 2115 15 same same JJ cord-015306-us58wwmp 2115 16 patient patient NN cord-015306-us58wwmp 2115 17 ( ( -LRB- cord-015306-us58wwmp 2115 18 p. p. NN cord-015306-us58wwmp 2116 1 Pro854Leu Pro854Leu NNP cord-015306-us58wwmp 2116 2 and and CC cord-015306-us58wwmp 2116 3 p. p. NN cord-015306-us58wwmp 2117 1 Val862Ile Val862Ile NNP cord-015306-us58wwmp 2117 2 ) ) -RRB- cord-015306-us58wwmp 2117 3 . . . cord-015306-us58wwmp 2118 1 The the DT cord-015306-us58wwmp 2118 2 p. p. NN cord-015306-us58wwmp 2119 1 Val862Ile Val862Ile NNS cord-015306-us58wwmp 2119 2 variation variation NN cord-015306-us58wwmp 2119 3 was be VBD cord-015306-us58wwmp 2119 4 also also RB cord-015306-us58wwmp 2119 5 found find VBN cord-015306-us58wwmp 2119 6 in in IN cord-015306-us58wwmp 2119 7 three three CD cord-015306-us58wwmp 2119 8 other other JJ cord-015306-us58wwmp 2119 9 patients patient NNS cord-015306-us58wwmp 2119 10 . . . cord-015306-us58wwmp 2120 1 It -PRON- PRP cord-015306-us58wwmp 2120 2 has have VBZ cord-015306-us58wwmp 2120 3 been be VBN cord-015306-us58wwmp 2120 4 shown show VBN cord-015306-us58wwmp 2120 5 that that IN cord-015306-us58wwmp 2120 6 these these DT cord-015306-us58wwmp 2120 7 variations variation NNS cord-015306-us58wwmp 2120 8 are be VBP cord-015306-us58wwmp 2120 9 rare rare JJ cord-015306-us58wwmp 2120 10 polymorphisms polymorphism NNS cord-015306-us58wwmp 2120 11 in in IN cord-015306-us58wwmp 2120 12 the the DT cord-015306-us58wwmp 2120 13 population population NN cord-015306-us58wwmp 2120 14 , , , cord-015306-us58wwmp 2120 15 but but CC cord-015306-us58wwmp 2120 16 they -PRON- PRP cord-015306-us58wwmp 2120 17 have have VBP cord-015306-us58wwmp 2120 18 already already RB cord-015306-us58wwmp 2120 19 been be VBN cord-015306-us58wwmp 2120 20 associated associate VBN cord-015306-us58wwmp 2120 21 to to IN cord-015306-us58wwmp 2120 22 Diego Diego NNP cord-015306-us58wwmp 2120 23 group group NN cord-015306-us58wwmp 2120 24 erythrocyte erythrocyte NN cord-015306-us58wwmp 2120 25 antigen antigen NN cord-015306-us58wwmp 2120 26 . . . cord-015306-us58wwmp 2121 1 In in IN cord-015306-us58wwmp 2121 2 exon exon NN cord-015306-us58wwmp 2121 3 1 1 CD cord-015306-us58wwmp 2121 4 of of IN cord-015306-us58wwmp 2121 5 ATP6V1B1 ATP6V1B1 NNP cord-015306-us58wwmp 2121 6 the the DT cord-015306-us58wwmp 2121 7 variation variation NN cord-015306-us58wwmp 2121 8 p. p. NN cord-015306-us58wwmp 2122 1 Met2 Met2 NNP cord-015306-us58wwmp 2122 2 ? ? , cord-015306-us58wwmp 2122 3 was be VBD cord-015306-us58wwmp 2122 4 presented present VBN cord-015306-us58wwmp 2122 5 in in IN cord-015306-us58wwmp 2122 6 twelve twelve CD cord-015306-us58wwmp 2122 7 patients patient NNS cord-015306-us58wwmp 2122 8 and and CC cord-015306-us58wwmp 2122 9 the the DT cord-015306-us58wwmp 2122 10 mutation mutation NN cord-015306-us58wwmp 2122 11 p. p. NN cord-015306-us58wwmp 2123 1 Thr30Ile Thr30Ile NNP cord-015306-us58wwmp 2123 2 was be VBD cord-015306-us58wwmp 2123 3 found find VBN cord-015306-us58wwmp 2123 4 in in IN cord-015306-us58wwmp 2123 5 six six CD cord-015306-us58wwmp 2123 6 patients patient NNS cord-015306-us58wwmp 2123 7 . . . cord-015306-us58wwmp 2124 1 Although although IN cord-015306-us58wwmp 2124 2 they -PRON- PRP cord-015306-us58wwmp 2124 3 occur occur VBP cord-015306-us58wwmp 2124 4 in in IN cord-015306-us58wwmp 2124 5 the the DT cord-015306-us58wwmp 2124 6 coding code VBG cord-015306-us58wwmp 2124 7 region region NN cord-015306-us58wwmp 2124 8 of of IN cord-015306-us58wwmp 2124 9 ATP6V1B1 ATP6V1B1 NNP cord-015306-us58wwmp 2124 10 , , , cord-015306-us58wwmp 2124 11 these these DT cord-015306-us58wwmp 2124 12 variations variation NNS cord-015306-us58wwmp 2124 13 have have VBP cord-015306-us58wwmp 2124 14 been be VBN cord-015306-us58wwmp 2124 15 described describe VBN cord-015306-us58wwmp 2124 16 as as IN cord-015306-us58wwmp 2124 17 highly highly RB cord-015306-us58wwmp 2124 18 frequent frequent JJ cord-015306-us58wwmp 2124 19 in in IN cord-015306-us58wwmp 2124 20 the the DT cord-015306-us58wwmp 2124 21 population population NN cord-015306-us58wwmp 2124 22 . . . cord-015306-us58wwmp 2125 1 Dent Dent NNP cord-015306-us58wwmp 2125 2 's 's POS cord-015306-us58wwmp 2125 3 disease disease NN cord-015306-us58wwmp 2125 4 is be VBZ cord-015306-us58wwmp 2125 5 an an DT cord-015306-us58wwmp 2125 6 X x NN cord-015306-us58wwmp 2125 7 -linked -linked JJ cord-015306-us58wwmp 2125 8 renal renal JJ cord-015306-us58wwmp 2125 9 proximal proximal JJ cord-015306-us58wwmp 2125 10 tubulopathy tubulopathy NN cord-015306-us58wwmp 2125 11 associated associate VBN cord-015306-us58wwmp 2125 12 with with IN cord-015306-us58wwmp 2125 13 mutations mutation NNS cord-015306-us58wwmp 2125 14 in in IN cord-015306-us58wwmp 2125 15 CLCN5 CLCN5 NNS cord-015306-us58wwmp 2126 1 ( ( -LRB- cord-015306-us58wwmp 2126 2 Dent Dent NNP cord-015306-us58wwmp 2126 3 's 's POS cord-015306-us58wwmp 2126 4 type type NN cord-015306-us58wwmp 2126 5 1 1 CD cord-015306-us58wwmp 2126 6 ) ) -RRB- cord-015306-us58wwmp 2126 7 and and CC cord-015306-us58wwmp 2126 8 OCRL1 OCRL1 NNP cord-015306-us58wwmp 2127 1 ( ( -LRB- cord-015306-us58wwmp 2127 2 Dent Dent NNP cord-015306-us58wwmp 2127 3 's 's POS cord-015306-us58wwmp 2127 4 type type NN cord-015306-us58wwmp 2127 5 2).OCRL1 2).ocrl1 CD cord-015306-us58wwmp 2127 6 mutations mutation NNS cord-015306-us58wwmp 2127 7 also also RB cord-015306-us58wwmp 2127 8 cause cause VBP cord-015306-us58wwmp 2127 9 the the DT cord-015306-us58wwmp 2127 10 oculocerebrorenal oculocerebrorenal JJ cord-015306-us58wwmp 2127 11 syndrome syndrome NN cord-015306-us58wwmp 2127 12 of of IN cord-015306-us58wwmp 2127 13 Lowe Lowe NNP cord-015306-us58wwmp 2127 14 . . . cord-015306-us58wwmp 2128 1 We -PRON- PRP cord-015306-us58wwmp 2128 2 report report VBP cord-015306-us58wwmp 2128 3 the the DT cord-015306-us58wwmp 2128 4 case case NN cord-015306-us58wwmp 2128 5 of of IN cord-015306-us58wwmp 2128 6 a a DT cord-015306-us58wwmp 2128 7 5 5 CD cord-015306-us58wwmp 2128 8 year year NN cord-015306-us58wwmp 2128 9 old old JJ cord-015306-us58wwmp 2128 10 boy boy NN cord-015306-us58wwmp 2128 11 with with IN cord-015306-us58wwmp 2128 12 Dent Dent NNP cord-015306-us58wwmp 2128 13 's 's POS cord-015306-us58wwmp 2128 14 disease disease NN cord-015306-us58wwmp 2128 15 associated associate VBN cord-015306-us58wwmp 2128 16 with with IN cord-015306-us58wwmp 2128 17 a a DT cord-015306-us58wwmp 2128 18 novel novel JJ cord-015306-us58wwmp 2128 19 hemizygous hemizygous JJ cord-015306-us58wwmp 2128 20 change change NN cord-015306-us58wwmp 2128 21 , , , cord-015306-us58wwmp 2128 22 c.2T c.2t XX cord-015306-us58wwmp 2128 23 > > XX cord-015306-us58wwmp 2128 24 C c NN cord-015306-us58wwmp 2128 25 p.(Met1 p.(met1 NN cord-015306-us58wwmp 2128 26 ) ) -RRB- cord-015306-us58wwmp 2128 27 in in IN cord-015306-us58wwmp 2128 28 exon exon NN cord-015306-us58wwmp 2128 29 1 1 CD cord-015306-us58wwmp 2128 30 of of IN cord-015306-us58wwmp 2128 31 OCRL OCRL NNP cord-015306-us58wwmp 2128 32 . . . cord-015306-us58wwmp 2129 1 Our -PRON- PRP$ cord-015306-us58wwmp 2129 2 patient patient NN cord-015306-us58wwmp 2129 3 presented present VBD cord-015306-us58wwmp 2129 4 at at IN cord-015306-us58wwmp 2129 5 3 3 CD cord-015306-us58wwmp 2129 6 years year NNS cord-015306-us58wwmp 2129 7 of of IN cord-015306-us58wwmp 2129 8 age age NN cord-015306-us58wwmp 2129 9 with with IN cord-015306-us58wwmp 2129 10 incidental incidental JJ cord-015306-us58wwmp 2129 11 finding finding NN cord-015306-us58wwmp 2129 12 of of IN cord-015306-us58wwmp 2129 13 non non JJ cord-015306-us58wwmp 2129 14 - - JJ cord-015306-us58wwmp 2129 15 nephrotic nephrotic JJ cord-015306-us58wwmp 2129 16 range range NN cord-015306-us58wwmp 2129 17 proteinuria proteinuria NN cord-015306-us58wwmp 2129 18 . . . cord-015306-us58wwmp 2130 1 He -PRON- PRP cord-015306-us58wwmp 2130 2 had have VBD cord-015306-us58wwmp 2130 3 elevated elevate VBN cord-015306-us58wwmp 2130 4 urinary urinary JJ cord-015306-us58wwmp 2130 5 beta beta NN cord-015306-us58wwmp 2130 6 -2 -2 NN cord-015306-us58wwmp 2130 7 microglobulin microglobulin NN cord-015306-us58wwmp 2130 8 , , , cord-015306-us58wwmp 2130 9 retinol retinol NN cord-015306-us58wwmp 2130 10 binding bind VBG cord-015306-us58wwmp 2130 11 protein protein NN cord-015306-us58wwmp 2130 12 and and CC cord-015306-us58wwmp 2130 13 hypercalciuria hypercalciuria NNP cord-015306-us58wwmp 2130 14 . . . cord-015306-us58wwmp 2131 1 He -PRON- PRP cord-015306-us58wwmp 2131 2 was be VBD cord-015306-us58wwmp 2131 3 developmentally developmentally RB cord-015306-us58wwmp 2131 4 normal normal JJ cord-015306-us58wwmp 2131 5 and and CC cord-015306-us58wwmp 2131 6 is be VBZ cord-015306-us58wwmp 2131 7 otherwise otherwise RB cord-015306-us58wwmp 2131 8 of of IN cord-015306-us58wwmp 2131 9 good good JJ cord-015306-us58wwmp 2131 10 general general JJ cord-015306-us58wwmp 2131 11 health health NN cord-015306-us58wwmp 2131 12 . . . cord-015306-us58wwmp 2132 1 Slit slit JJ cord-015306-us58wwmp 2132 2 lamp lamp NN cord-015306-us58wwmp 2132 3 examination examination NN cord-015306-us58wwmp 2132 4 and and CC cord-015306-us58wwmp 2132 5 vision vision NN cord-015306-us58wwmp 2132 6 were be VBD cord-015306-us58wwmp 2132 7 normal normal JJ cord-015306-us58wwmp 2132 8 . . . cord-015306-us58wwmp 2133 1 He -PRON- PRP cord-015306-us58wwmp 2133 2 had have VBD cord-015306-us58wwmp 2133 3 normal normal JJ cord-015306-us58wwmp 2133 4 renal renal JJ cord-015306-us58wwmp 2133 5 function function NN cord-015306-us58wwmp 2133 6 but but CC cord-015306-us58wwmp 2133 7 had have VBD cord-015306-us58wwmp 2133 8 very very RB cord-015306-us58wwmp 2133 9 poor poor JJ cord-015306-us58wwmp 2133 10 renal renal JJ cord-015306-us58wwmp 2133 11 accumulation accumulation NN cord-015306-us58wwmp 2133 12 of of IN cord-015306-us58wwmp 2133 13 99mTc 99mtc NN cord-015306-us58wwmp 2133 14 - - HYPH cord-015306-us58wwmp 2133 15 DMSA DMSA NNS cord-015306-us58wwmp 2133 16 on on IN cord-015306-us58wwmp 2133 17 renoscintigraphy renoscintigraphy NNP cord-015306-us58wwmp 2133 18 . . . cord-015306-us58wwmp 2134 1 Genetic genetic JJ cord-015306-us58wwmp 2134 2 testing testing NN cord-015306-us58wwmp 2134 3 identified identify VBD cord-015306-us58wwmp 2134 4 a a DT cord-015306-us58wwmp 2134 5 hemizygous hemizygous JJ cord-015306-us58wwmp 2134 6 change change NN cord-015306-us58wwmp 2134 7 , , , cord-015306-us58wwmp 2134 8 c.2T c.2t XX cord-015306-us58wwmp 2134 9 > > XX cord-015306-us58wwmp 2134 10 C c NN cord-015306-us58wwmp 2134 11 p.(Met1 p.(met1 NN cord-015306-us58wwmp 2134 12 ) ) -RRB- cord-015306-us58wwmp 2134 13 , , , cord-015306-us58wwmp 2134 14 in in IN cord-015306-us58wwmp 2134 15 exon exon NN cord-015306-us58wwmp 2134 16 1 1 CD cord-015306-us58wwmp 2134 17 of of IN cord-015306-us58wwmp 2134 18 OCRL OCRL NNP cord-015306-us58wwmp 2134 19 , , , cord-015306-us58wwmp 2134 20 which which WDT cord-015306-us58wwmp 2134 21 affects affect VBZ cord-015306-us58wwmp 2134 22 the the DT cord-015306-us58wwmp 2134 23 translation translation NN cord-015306-us58wwmp 2134 24 initiation initiation NN cord-015306-us58wwmp 2134 25 codon codon NNP cord-015306-us58wwmp 2134 26 . . . cord-015306-us58wwmp 2135 1 His -PRON- PRP$ cord-015306-us58wwmp 2135 2 healthy healthy JJ cord-015306-us58wwmp 2135 3 8 8 CD cord-015306-us58wwmp 2135 4 year year NN cord-015306-us58wwmp 2135 5 old old JJ cord-015306-us58wwmp 2135 6 brother brother NN cord-015306-us58wwmp 2135 7 who who WP cord-015306-us58wwmp 2135 8 was be VBD cord-015306-us58wwmp 2135 9 also also RB cord-015306-us58wwmp 2135 10 found find VBN cord-015306-us58wwmp 2135 11 to to TO cord-015306-us58wwmp 2135 12 have have VB cord-015306-us58wwmp 2135 13 low low JJ cord-015306-us58wwmp 2135 14 -molecular -molecular HYPH cord-015306-us58wwmp 2135 15 weight weight NN cord-015306-us58wwmp 2135 16 proteinuria proteinuria NN cord-015306-us58wwmp 2135 17 and and CC cord-015306-us58wwmp 2135 18 hypercalciuria hypercalciuria NNP cord-015306-us58wwmp 2135 19 , , , cord-015306-us58wwmp 2135 20 is be VBZ cord-015306-us58wwmp 2135 21 currently currently RB cord-015306-us58wwmp 2135 22 being be VBG cord-015306-us58wwmp 2135 23 investigated investigate VBN cord-015306-us58wwmp 2135 24 . . . cord-015306-us58wwmp 2136 1 To to IN cord-015306-us58wwmp 2136 2 the the DT cord-015306-us58wwmp 2136 3 best good JJS cord-015306-us58wwmp 2136 4 of of IN cord-015306-us58wwmp 2136 5 our -PRON- PRP$ cord-015306-us58wwmp 2136 6 knowledge knowledge NN cord-015306-us58wwmp 2136 7 , , , cord-015306-us58wwmp 2136 8 the the DT cord-015306-us58wwmp 2136 9 hemizygous hemizygous JJ cord-015306-us58wwmp 2136 10 change change NN cord-015306-us58wwmp 2136 11 , , , cord-015306-us58wwmp 2136 12 c.2 c.2 NNP cord-015306-us58wwmp 2136 13 T t NN cord-015306-us58wwmp 2136 14 > > XX cord-015306-us58wwmp 2137 1 C C NNP cord-015306-us58wwmp 2137 2 p.(Met1 p.(Met1 NNP cord-015306-us58wwmp 2137 3 ? ? . cord-015306-us58wwmp 2137 4 ) ) -RRB- cord-015306-us58wwmp 2138 1 in in IN cord-015306-us58wwmp 2138 2 exon exon NN cord-015306-us58wwmp 2138 3 1 1 CD cord-015306-us58wwmp 2138 4 of of IN cord-015306-us58wwmp 2138 5 the the DT cord-015306-us58wwmp 2138 6 OCRL ocrl JJ cord-015306-us58wwmp 2138 7 gene gene NN cord-015306-us58wwmp 2138 8 which which WDT cord-015306-us58wwmp 2138 9 was be VBD cord-015306-us58wwmp 2138 10 identified identify VBN cord-015306-us58wwmp 2138 11 in in IN cord-015306-us58wwmp 2138 12 our -PRON- PRP$ cord-015306-us58wwmp 2138 13 patient patient NN cord-015306-us58wwmp 2138 14 with with IN cord-015306-us58wwmp 2138 15 Dent Dent NNP cord-015306-us58wwmp 2138 16 's 's POS cord-015306-us58wwmp 2138 17 disease disease NN cord-015306-us58wwmp 2138 18 represents represent VBZ cord-015306-us58wwmp 2138 19 a a DT cord-015306-us58wwmp 2138 20 novel novel JJ cord-015306-us58wwmp 2138 21 variant variant NN cord-015306-us58wwmp 2138 22 which which WDT cord-015306-us58wwmp 2138 23 has have VBZ cord-015306-us58wwmp 2138 24 not not RB cord-015306-us58wwmp 2138 25 been be VBN cord-015306-us58wwmp 2138 26 previously previously RB cord-015306-us58wwmp 2138 27 reported report VBN cord-015306-us58wwmp 2138 28 in in IN cord-015306-us58wwmp 2138 29 a a DT cord-015306-us58wwmp 2138 30 Dent Dent NNP cord-015306-us58wwmp 2138 31 's 's POS cord-015306-us58wwmp 2138 32 disease disease NN cord-015306-us58wwmp 2138 33 patient patient NN cord-015306-us58wwmp 2138 34 . . . cord-015306-us58wwmp 2139 1 Abstract abstract JJ cord-015306-us58wwmp 2139 2 # # NN cord-015306-us58wwmp 2139 3 P p NN cord-015306-us58wwmp 2139 4 - - HYPH cord-015306-us58wwmp 2139 5 SAT274 SAT274 NNP cord-015306-us58wwmp 2139 6 Enamel Enamel NNP cord-015306-us58wwmp 2139 7 - - HYPH cord-015306-us58wwmp 2139 8 renal renal JJ cord-015306-us58wwmp 2139 9 syndrome syndrome NN cord-015306-us58wwmp 2139 10 associated associate VBN cord-015306-us58wwmp 2139 11 to to IN cord-015306-us58wwmp 2139 12 splenic splenic JJ cord-015306-us58wwmp 2139 13 and and CC cord-015306-us58wwmp 2139 14 ovarian ovarian JJ cord-015306-us58wwmp 2139 15 calcifications calcification NNS cord-015306-us58wwmp 2139 16 : : : cord-015306-us58wwmp 2139 17 a a DT cord-015306-us58wwmp 2139 18 case case NN cord-015306-us58wwmp 2139 19 report report NN cord-015306-us58wwmp 2139 20 Sameh Sameh NNP cord-015306-us58wwmp 2139 21 Mabrouk Mabrouk NNP cord-015306-us58wwmp 2139 22 , , , cord-015306-us58wwmp 2139 23 Noura Noura NNP cord-015306-us58wwmp 2139 24 Zouari Zouari NNP cord-015306-us58wwmp 2139 25 , , , cord-015306-us58wwmp 2139 26 Houda Houda NNP cord-015306-us58wwmp 2139 27 Ajmi Ajmi NNP cord-015306-us58wwmp 2139 28 , , , cord-015306-us58wwmp 2139 29 Jalel Jalel NNP cord-015306-us58wwmp 2139 30 Chemli Chemli NNP cord-015306-us58wwmp 2139 31 , , , cord-015306-us58wwmp 2139 32 Menair Menair NNP cord-015306-us58wwmp 2139 33 Tfifha Tfifha NNP cord-015306-us58wwmp 2139 34 , , , cord-015306-us58wwmp 2139 35 Saida Saida NNP cord-015306-us58wwmp 2139 36 Hassayoun Hassayoun NNP cord-015306-us58wwmp 2139 37 , , , cord-015306-us58wwmp 2139 38 Saoussen Saoussen NNP cord-015306-us58wwmp 2139 39 Abroug Abroug NNP cord-015306-us58wwmp 2139 40 , , , cord-015306-us58wwmp 2139 41 Abdelaziz Abdelaziz NNP cord-015306-us58wwmp 2139 42 Harbi Harbi NNP cord-015306-us58wwmp 2139 43 Pediatrics Pediatrics NNP cord-015306-us58wwmp 2139 44 , , , cord-015306-us58wwmp 2139 45 university university NN cord-015306-us58wwmp 2139 46 hospital hospital NN cord-015306-us58wwmp 2139 47 of of IN cord-015306-us58wwmp 2139 48 Sahloul Sahloul NNP cord-015306-us58wwmp 2139 49 , , , cord-015306-us58wwmp 2139 50 Sousse Sousse NNP cord-015306-us58wwmp 2139 51 , , , cord-015306-us58wwmp 2139 52 Tunisia Tunisia NNP cord-015306-us58wwmp 2139 53 Enamel Enamel NNP cord-015306-us58wwmp 2139 54 - - HYPH cord-015306-us58wwmp 2139 55 renal renal JJ cord-015306-us58wwmp 2139 56 syndrome syndrome NN cord-015306-us58wwmp 2139 57 ( ( -LRB- cord-015306-us58wwmp 2139 58 OMIM204690 omim204690 CD cord-015306-us58wwmp 2139 59 ) ) -RRB- cord-015306-us58wwmp 2140 1 is be VBZ cord-015306-us58wwmp 2140 2 a a DT cord-015306-us58wwmp 2140 3 rare rare JJ cord-015306-us58wwmp 2140 4 condition condition NN cord-015306-us58wwmp 2140 5 characterized characterize VBN cord-015306-us58wwmp 2140 6 by by IN cord-015306-us58wwmp 2140 7 amelogenosis amelogenosis NN cord-015306-us58wwmp 2140 8 imperfecta imperfecta NN cord-015306-us58wwmp 2140 9 and and CC cord-015306-us58wwmp 2140 10 nephrocalcinosis nephrocalcinosis NN cord-015306-us58wwmp 2140 11 . . . cord-015306-us58wwmp 2141 1 We -PRON- PRP cord-015306-us58wwmp 2141 2 report report VBP cord-015306-us58wwmp 2141 3 a a DT cord-015306-us58wwmp 2141 4 new new JJ cord-015306-us58wwmp 2141 5 pediatric pediatric JJ cord-015306-us58wwmp 2141 6 case case NN cord-015306-us58wwmp 2141 7 of of IN cord-015306-us58wwmp 2141 8 this this DT cord-015306-us58wwmp 2141 9 rare rare JJ cord-015306-us58wwmp 2141 10 association association NN cord-015306-us58wwmp 2141 11 with with IN cord-015306-us58wwmp 2141 12 the the DT cord-015306-us58wwmp 2141 13 particularity particularity NN cord-015306-us58wwmp 2141 14 of of IN cord-015306-us58wwmp 2141 15 associated associated JJ cord-015306-us58wwmp 2141 16 splenic splenic JJ cord-015306-us58wwmp 2141 17 and and CC cord-015306-us58wwmp 2141 18 ovarian ovarian JJ cord-015306-us58wwmp 2141 19 calcifications calcification NNS cord-015306-us58wwmp 2141 20 . . . cord-015306-us58wwmp 2142 1 This this DT cord-015306-us58wwmp 2142 2 report report NN cord-015306-us58wwmp 2142 3 concerns concern VBZ cord-015306-us58wwmp 2142 4 a a DT cord-015306-us58wwmp 2142 5 13-year 13-year JJ cord-015306-us58wwmp 2142 6 - - HYPH cord-015306-us58wwmp 2142 7 old old JJ cord-015306-us58wwmp 2142 8 girl girl NN cord-015306-us58wwmp 2142 9 , , , cord-015306-us58wwmp 2142 10 born bear VBN cord-015306-us58wwmp 2142 11 to to IN cord-015306-us58wwmp 2142 12 consanguineous consanguineous JJ cord-015306-us58wwmp 2142 13 parents parent NNS cord-015306-us58wwmp 2142 14 ( ( -LRB- cord-015306-us58wwmp 2142 15 first first JJ cord-015306-us58wwmp 2142 16 degree degree NN cord-015306-us58wwmp 2142 17 cousins cousin NNS cord-015306-us58wwmp 2142 18 ) ) -RRB- cord-015306-us58wwmp 2142 19 . . . cord-015306-us58wwmp 2143 1 She -PRON- PRP cord-015306-us58wwmp 2143 2 has have VBZ cord-015306-us58wwmp 2143 3 no no DT cord-015306-us58wwmp 2143 4 family family NN cord-015306-us58wwmp 2143 5 history history NN cord-015306-us58wwmp 2143 6 of of IN cord-015306-us58wwmp 2143 7 nephrocalcinosis nephrocalcinosis NNP cord-015306-us58wwmp 2143 8 or or CC cord-015306-us58wwmp 2143 9 kidneydisease kidneydisease NNP cord-015306-us58wwmp 2143 10 . . . cord-015306-us58wwmp 2144 1 Her -PRON- PRP$ cord-015306-us58wwmp 2144 2 unique unique JJ cord-015306-us58wwmp 2144 3 brother brother NN cord-015306-us58wwmp 2144 4 , , , cord-015306-us58wwmp 2144 5 aged aged JJ cord-015306-us58wwmp 2144 6 8 8 CD cord-015306-us58wwmp 2144 7 years year NNS cord-015306-us58wwmp 2144 8 , , , cord-015306-us58wwmp 2144 9 is be VBZ cord-015306-us58wwmp 2144 10 in in IN cord-015306-us58wwmp 2144 11 good good JJ cord-015306-us58wwmp 2144 12 health health NN cord-015306-us58wwmp 2144 13 and and CC cord-015306-us58wwmp 2144 14 has have VBZ cord-015306-us58wwmp 2144 15 no no DT cord-015306-us58wwmp 2144 16 dental dental JJ cord-015306-us58wwmp 2144 17 or or CC cord-015306-us58wwmp 2144 18 renal renal JJ cord-015306-us58wwmp 2144 19 problems problem NNS cord-015306-us58wwmp 2144 20 . . . cord-015306-us58wwmp 2145 1 She -PRON- PRP cord-015306-us58wwmp 2145 2 was be VBD cord-015306-us58wwmp 2145 3 first first RB cord-015306-us58wwmp 2145 4 seen see VBN cord-015306-us58wwmp 2145 5 at at IN cord-015306-us58wwmp 2145 6 the the DT cord-015306-us58wwmp 2145 7 age age NN cord-015306-us58wwmp 2145 8 of of IN cord-015306-us58wwmp 2145 9 12 12 CD cord-015306-us58wwmp 2145 10 years year NNS cord-015306-us58wwmp 2145 11 in in IN cord-015306-us58wwmp 2145 12 dentistrydepartment dentistrydepartment NN cord-015306-us58wwmp 2145 13 because because IN cord-015306-us58wwmp 2145 14 of of IN cord-015306-us58wwmp 2145 15 dental dental JJ cord-015306-us58wwmp 2145 16 abnormalities abnormality NNS cord-015306-us58wwmp 2145 17 , , , cord-015306-us58wwmp 2145 18 the the DT cord-015306-us58wwmp 2145 19 diagnosis diagnosis NN cord-015306-us58wwmp 2145 20 of of IN cord-015306-us58wwmp 2145 21 amelogenosis amelogenosis NN cord-015306-us58wwmp 2145 22 imperfecta imperfecta NN cord-015306-us58wwmp 2145 23 was be VBD cord-015306-us58wwmp 2145 24 made make VBN cord-015306-us58wwmp 2145 25 and and CC cord-015306-us58wwmp 2145 26 the the DT cord-015306-us58wwmp 2145 27 patient patient NN cord-015306-us58wwmp 2145 28 was be VBD cord-015306-us58wwmp 2145 29 further further RB cord-015306-us58wwmp 2145 30 investigated investigate VBN cord-015306-us58wwmp 2145 31 . . . cord-015306-us58wwmp 2146 1 A a DT cord-015306-us58wwmp 2146 2 renal renal JJ cord-015306-us58wwmp 2146 3 ultrasound ultrasound NN cord-015306-us58wwmp 2146 4 showed show VBD cord-015306-us58wwmp 2146 5 a a DT cord-015306-us58wwmp 2146 6 bilateral bilateral JJ cord-015306-us58wwmp 2146 7 medullary medullary JJ cord-015306-us58wwmp 2146 8 nephrocalcinosis nephrocalcinosis NN cord-015306-us58wwmp 2146 9 . . . cord-015306-us58wwmp 2147 1 CT CT NNP cord-015306-us58wwmp 2147 2 confirmed confirm VBD cord-015306-us58wwmp 2147 3 bilateral bilateral JJ cord-015306-us58wwmp 2147 4 nephrocalcinosis nephrocalcinosis NN cord-015306-us58wwmp 2147 5 which which WDT cord-015306-us58wwmp 2147 6 was be VBD cord-015306-us58wwmp 2147 7 associated associate VBN cord-015306-us58wwmp 2147 8 to to IN cord-015306-us58wwmp 2147 9 ovarian ovarian JJ cord-015306-us58wwmp 2147 10 and and CC cord-015306-us58wwmp 2147 11 splenic splenic JJ cord-015306-us58wwmp 2147 12 calcifications calcification NNS cord-015306-us58wwmp 2147 13 . . . cord-015306-us58wwmp 2148 1 Besides besides IN cord-015306-us58wwmp 2148 2 this this DT cord-015306-us58wwmp 2148 3 young young JJ cord-015306-us58wwmp 2148 4 girl girl NN cord-015306-us58wwmp 2148 5 has have VBZ cord-015306-us58wwmp 2148 6 a a DT cord-015306-us58wwmp 2148 7 normal normal JJ cord-015306-us58wwmp 2148 8 growth growth NN cord-015306-us58wwmp 2148 9 , , , cord-015306-us58wwmp 2148 10 her -PRON- PRP$ cord-015306-us58wwmp 2148 11 puberty puberty NN cord-015306-us58wwmp 2148 12 began begin VBD cord-015306-us58wwmp 2148 13 at at IN cord-015306-us58wwmp 2148 14 the the DT cord-015306-us58wwmp 2148 15 age age NN cord-015306-us58wwmp 2148 16 of of IN cord-015306-us58wwmp 2148 17 12 12 CD cord-015306-us58wwmp 2148 18 years year NNS cord-015306-us58wwmp 2148 19 . . . cord-015306-us58wwmp 2149 1 Laboratory laboratory NN cord-015306-us58wwmp 2149 2 findings finding NNS cord-015306-us58wwmp 2149 3 including include VBG cord-015306-us58wwmp 2149 4 serum serum NN cord-015306-us58wwmp 2149 5 electrolytes electrolyte NNS cord-015306-us58wwmp 2149 6 , , , cord-015306-us58wwmp 2149 7 urea urea NN cord-015306-us58wwmp 2149 8 , , , cord-015306-us58wwmp 2149 9 creatinine creatinine NN cord-015306-us58wwmp 2149 10 , , , cord-015306-us58wwmp 2149 11 calcium calcium NN cord-015306-us58wwmp 2149 12 , , , cord-015306-us58wwmp 2149 13 phosphate phosphate NN cord-015306-us58wwmp 2149 14 , , , cord-015306-us58wwmp 2149 15 parathormone parathormone NN cord-015306-us58wwmp 2149 16 and and CC cord-015306-us58wwmp 2149 17 alkaline alkaline JJ cord-015306-us58wwmp 2149 18 phosphatase phosphatase NN cord-015306-us58wwmp 2149 19 were be VBD cord-015306-us58wwmp 2149 20 within within IN cord-015306-us58wwmp 2149 21 normal normal JJ cord-015306-us58wwmp 2149 22 ranges range NNS cord-015306-us58wwmp 2149 23 . . . cord-015306-us58wwmp 2150 1 On on IN cord-015306-us58wwmp 2150 2 urine urine NN cord-015306-us58wwmp 2150 3 examination examination NN cord-015306-us58wwmp 2150 4 we -PRON- PRP cord-015306-us58wwmp 2150 5 found find VBD cord-015306-us58wwmp 2150 6 a a DT cord-015306-us58wwmp 2150 7 hypocalciuria hypocalciuria NN cord-015306-us58wwmp 2150 8 , , , cord-015306-us58wwmp 2150 9 with with IN cord-015306-us58wwmp 2150 10 normal normal JJ cord-015306-us58wwmp 2150 11 sodium sodium NN cord-015306-us58wwmp 2150 12 and and CC cord-015306-us58wwmp 2150 13 phosphate phosphate NN cord-015306-us58wwmp 2150 14 excretion excretion NN cord-015306-us58wwmp 2150 15 . . . cord-015306-us58wwmp 2151 1 The the DT cord-015306-us58wwmp 2151 2 patient patient NN cord-015306-us58wwmp 2151 3 is be VBZ cord-015306-us58wwmp 2151 4 regularly regularly RB cord-015306-us58wwmp 2151 5 seen see VBN cord-015306-us58wwmp 2151 6 in in IN cord-015306-us58wwmp 2151 7 both both DT cord-015306-us58wwmp 2151 8 dentistry dentistry NNP cord-015306-us58wwmp 2151 9 department department NNP cord-015306-us58wwmp 2151 10 and and CC cord-015306-us58wwmp 2151 11 pediatrics pediatrics NNP cord-015306-us58wwmp 2151 12 . . . cord-015306-us58wwmp 2152 1 The the DT cord-015306-us58wwmp 2152 2 aim aim NN cord-015306-us58wwmp 2152 3 of of IN cord-015306-us58wwmp 2152 4 this this DT cord-015306-us58wwmp 2152 5 report report NN cord-015306-us58wwmp 2152 6 is be VBZ cord-015306-us58wwmp 2152 7 to to TO cord-015306-us58wwmp 2152 8 highlight highlight VB cord-015306-us58wwmp 2152 9 the the DT cord-015306-us58wwmp 2152 10 important important JJ cord-015306-us58wwmp 2152 11 role role NN cord-015306-us58wwmp 2152 12 of of IN cord-015306-us58wwmp 2152 13 pediatricians pediatrician NNS cord-015306-us58wwmp 2152 14 as as RB cord-015306-us58wwmp 2152 15 well well RB cord-015306-us58wwmp 2152 16 as as IN cord-015306-us58wwmp 2152 17 dentists dentist NNS cord-015306-us58wwmp 2152 18 in in IN cord-015306-us58wwmp 2152 19 recognizing recognize VBG cord-015306-us58wwmp 2152 20 this this DT cord-015306-us58wwmp 2152 21 rare rare JJ cord-015306-us58wwmp 2152 22 and and CC cord-015306-us58wwmp 2152 23 uncommon uncommon JJ cord-015306-us58wwmp 2152 24 syndrome syndrome NN cord-015306-us58wwmp 2152 25 . . . cord-015306-us58wwmp 2153 1 Objective objective NN cord-015306-us58wwmp 2153 2 : : : cord-015306-us58wwmp 2154 1 IPEX IPEX NNP cord-015306-us58wwmp 2154 2 syndrome syndrome NN cord-015306-us58wwmp 2154 3 , , , cord-015306-us58wwmp 2154 4 a a DT cord-015306-us58wwmp 2154 5 hereditary hereditary JJ cord-015306-us58wwmp 2154 6 ( ( -LRB- cord-015306-us58wwmp 2154 7 X x NN cord-015306-us58wwmp 2154 8 - - HYPH cord-015306-us58wwmp 2154 9 linked link VBN cord-015306-us58wwmp 2154 10 ) ) -RRB- cord-015306-us58wwmp 2154 11 immune immune JJ cord-015306-us58wwmp 2154 12 dysregulation dysregulation NN cord-015306-us58wwmp 2154 13 with with IN cord-015306-us58wwmp 2154 14 autoimmune autoimmune JJ cord-015306-us58wwmp 2154 15 polyendocrinopathy polyendocrinopathy NN cord-015306-us58wwmp 2154 16 and and CC cord-015306-us58wwmp 2154 17 enteropathy enteropathy NNP cord-015306-us58wwmp 2154 18 , , , cord-015306-us58wwmp 2154 19 as as IN cord-015306-us58wwmp 2154 20 the the DT cord-015306-us58wwmp 2154 21 basic basic JJ cord-015306-us58wwmp 2154 22 manifestations manifestation NNS cord-015306-us58wwmp 2154 23 , , , cord-015306-us58wwmp 2154 24 presents present VBZ cord-015306-us58wwmp 2154 25 a a DT cord-015306-us58wwmp 2154 26 rare rare JJ cord-015306-us58wwmp 2154 27 and and CC cord-015306-us58wwmp 2154 28 severe severe JJ cord-015306-us58wwmp 2154 29 disease disease NN cord-015306-us58wwmp 2154 30 . . . cord-015306-us58wwmp 2155 1 The the DT cord-015306-us58wwmp 2155 2 objective objective NN cord-015306-us58wwmp 2155 3 of of IN cord-015306-us58wwmp 2155 4 this this DT cord-015306-us58wwmp 2155 5 case case NN cord-015306-us58wwmp 2155 6 report report NN cord-015306-us58wwmp 2155 7 is be VBZ cord-015306-us58wwmp 2155 8 to to TO cord-015306-us58wwmp 2155 9 highlight highlight VB cord-015306-us58wwmp 2155 10 the the DT cord-015306-us58wwmp 2155 11 pleomorphism pleomorphism NN cord-015306-us58wwmp 2155 12 of of IN cord-015306-us58wwmp 2155 13 the the DT cord-015306-us58wwmp 2155 14 syndrome syndrome NN cord-015306-us58wwmp 2155 15 . . . cord-015306-us58wwmp 2156 1 Methods method NNS cord-015306-us58wwmp 2156 2 : : : cord-015306-us58wwmp 2157 1 The the DT cord-015306-us58wwmp 2157 2 authors author NNS cord-015306-us58wwmp 2157 3 report report VBP cord-015306-us58wwmp 2157 4 the the DT cord-015306-us58wwmp 2157 5 case case NN cord-015306-us58wwmp 2157 6 of of IN cord-015306-us58wwmp 2157 7 a a DT cord-015306-us58wwmp 2157 8 male male JJ cord-015306-us58wwmp 2157 9 infant infant NN cord-015306-us58wwmp 2157 10 , , , cord-015306-us58wwmp 2157 11 with with IN cord-015306-us58wwmp 2157 12 a a DT cord-015306-us58wwmp 2157 13 family family NN cord-015306-us58wwmp 2157 14 history history NN cord-015306-us58wwmp 2157 15 of of IN cord-015306-us58wwmp 2157 16 three three CD cord-015306-us58wwmp 2157 17 male male JJ cord-015306-us58wwmp 2157 18 siblings sibling NNS cord-015306-us58wwmp 2157 19 affected affect VBN cord-015306-us58wwmp 2157 20 by by IN cord-015306-us58wwmp 2157 21 IPEX IPEX NNP cord-015306-us58wwmp 2157 22 syndrome syndrome NN cord-015306-us58wwmp 2157 23 . . . cord-015306-us58wwmp 2158 1 The the DT cord-015306-us58wwmp 2158 2 patients patient NNS cord-015306-us58wwmp 2158 3 ' ' POS cord-015306-us58wwmp 2158 4 medical medical JJ cord-015306-us58wwmp 2158 5 records record NNS cord-015306-us58wwmp 2158 6 were be VBD cord-015306-us58wwmp 2158 7 reviewed review VBN cord-015306-us58wwmp 2158 8 in in IN cord-015306-us58wwmp 2158 9 order order NN cord-015306-us58wwmp 2158 10 to to TO cord-015306-us58wwmp 2158 11 describe describe VB cord-015306-us58wwmp 2158 12 the the DT cord-015306-us58wwmp 2158 13 case case NN cord-015306-us58wwmp 2158 14 of of IN cord-015306-us58wwmp 2158 15 the the DT cord-015306-us58wwmp 2158 16 youngest young JJS cord-015306-us58wwmp 2158 17 one one CD cord-015306-us58wwmp 2158 18 . . . cord-015306-us58wwmp 2159 1 Results result NNS cord-015306-us58wwmp 2159 2 : : : cord-015306-us58wwmp 2160 1 During during IN cord-015306-us58wwmp 2160 2 the the DT cord-015306-us58wwmp 2160 3 follow follow NN cord-015306-us58wwmp 2160 4 - - HYPH cord-015306-us58wwmp 2160 5 up up NN cord-015306-us58wwmp 2160 6 of of IN cord-015306-us58wwmp 2160 7 the the DT cord-015306-us58wwmp 2160 8 youngest young JJS cord-015306-us58wwmp 2160 9 of of IN cord-015306-us58wwmp 2160 10 three three CD cord-015306-us58wwmp 2160 11 siblings sibling NNS cord-015306-us58wwmp 2160 12 , , , cord-015306-us58wwmp 2160 13 who who WP cord-015306-us58wwmp 2160 14 presented present VBD cord-015306-us58wwmp 2160 15 eczema eczema NN cord-015306-us58wwmp 2160 16 and and CC cord-015306-us58wwmp 2160 17 intestinal intestinal JJ cord-015306-us58wwmp 2160 18 manifestation manifestation NN cord-015306-us58wwmp 2160 19 , , , cord-015306-us58wwmp 2160 20 without without IN cord-015306-us58wwmp 2160 21 compromised compromise VBN cord-015306-us58wwmp 2160 22 pancreatic pancreatic JJ cord-015306-us58wwmp 2160 23 and and CC cord-015306-us58wwmp 2160 24 thyroid thyroid NN cord-015306-us58wwmp 2160 25 function function NN cord-015306-us58wwmp 2160 26 , , , cord-015306-us58wwmp 2160 27 different different JJ cord-015306-us58wwmp 2160 28 from from IN cord-015306-us58wwmp 2160 29 other other JJ cord-015306-us58wwmp 2160 30 two two CD cord-015306-us58wwmp 2160 31 siblings sibling NNS cord-015306-us58wwmp 2160 32 , , , cord-015306-us58wwmp 2160 33 it -PRON- PRP cord-015306-us58wwmp 2160 34 was be VBD cord-015306-us58wwmp 2160 35 noticed notice VBN cord-015306-us58wwmp 2160 36 the the DT cord-015306-us58wwmp 2160 37 pattern pattern NN cord-015306-us58wwmp 2160 38 of of IN cord-015306-us58wwmp 2160 39 Dent Dent NNP cord-015306-us58wwmp 2160 40 's 's POS cord-015306-us58wwmp 2160 41 disease disease NN cord-015306-us58wwmp 2160 42 . . . cord-015306-us58wwmp 2161 1 We -PRON- PRP cord-015306-us58wwmp 2161 2 registered register VBD cord-015306-us58wwmp 2161 3 hypophosphatemia hypophosphatemia NNP cord-015306-us58wwmp 2161 4 , , , cord-015306-us58wwmp 2161 5 hypercalciuria hypercalciuria NNP cord-015306-us58wwmp 2161 6 , , , cord-015306-us58wwmp 2161 7 glycosuria glycosuria NNP cord-015306-us58wwmp 2161 8 , , , cord-015306-us58wwmp 2161 9 low low JJ cord-015306-us58wwmp 2161 10 molecular molecular JJ cord-015306-us58wwmp 2161 11 weight weight NN cord-015306-us58wwmp 2161 12 proteinuria proteinuria NN cord-015306-us58wwmp 2161 13 and and CC cord-015306-us58wwmp 2161 14 ultrasound ultrasound NN cord-015306-us58wwmp 2161 15 revealed reveal VBD cord-015306-us58wwmp 2161 16 second second JJ cord-015306-us58wwmp 2161 17 stage stage NN cord-015306-us58wwmp 2161 18 bilateral bilateral JJ cord-015306-us58wwmp 2161 19 nephrocalcinosis nephrocalcinosis NN cord-015306-us58wwmp 2161 20 . . . cord-015306-us58wwmp 2162 1 In in IN cord-015306-us58wwmp 2162 2 this this DT cord-015306-us58wwmp 2162 3 child child NN cord-015306-us58wwmp 2162 4 there there EX cord-015306-us58wwmp 2162 5 was be VBD cord-015306-us58wwmp 2162 6 no no DT cord-015306-us58wwmp 2162 7 apparent apparent JJ cord-015306-us58wwmp 2162 8 glomerular glomerular JJ cord-015306-us58wwmp 2162 9 involvement involvement NN cord-015306-us58wwmp 2162 10 , , , cord-015306-us58wwmp 2162 11 as as IN cord-015306-us58wwmp 2162 12 it -PRON- PRP cord-015306-us58wwmp 2162 13 was be VBD cord-015306-us58wwmp 2162 14 seen see VBN cord-015306-us58wwmp 2162 15 in in IN cord-015306-us58wwmp 2162 16 the the DT cord-015306-us58wwmp 2162 17 eldest eld JJS cord-015306-us58wwmp 2162 18 sibling sibling NN cord-015306-us58wwmp 2162 19 . . . cord-015306-us58wwmp 2163 1 Conclusion conclusion NN cord-015306-us58wwmp 2163 2 : : : cord-015306-us58wwmp 2164 1 Dent Dent NNP cord-015306-us58wwmp 2164 2 's 's POS cord-015306-us58wwmp 2164 3 disease disease NN cord-015306-us58wwmp 2164 4 is be VBZ cord-015306-us58wwmp 2164 5 an an DT cord-015306-us58wwmp 2164 6 X x NN cord-015306-us58wwmp 2164 7 - - HYPH cord-015306-us58wwmp 2164 8 linked link VBN cord-015306-us58wwmp 2164 9 renal renal JJ cord-015306-us58wwmp 2164 10 proximal proximal JJ cord-015306-us58wwmp 2164 11 tubulopathy tubulopathy NN cord-015306-us58wwmp 2164 12 associated associate VBN cord-015306-us58wwmp 2164 13 with with IN cord-015306-us58wwmp 2164 14 mutations mutation NNS cord-015306-us58wwmp 2164 15 in in IN cord-015306-us58wwmp 2164 16 the the DT cord-015306-us58wwmp 2164 17 chloride chloride NN cord-015306-us58wwmp 2164 18 channel channel NN cord-015306-us58wwmp 2164 19 gene gene NN cord-015306-us58wwmp 2164 20 CLCN5 CLCN5 NNP cord-015306-us58wwmp 2165 1 ( ( -LRB- cord-015306-us58wwmp 2165 2 Xp11.22 Xp11.22 NNP cord-015306-us58wwmp 2165 3 ) ) -RRB- cord-015306-us58wwmp 2165 4 , , , cord-015306-us58wwmp 2165 5 which which WDT cord-015306-us58wwmp 2165 6 is be VBZ cord-015306-us58wwmp 2165 7 next next JJ cord-015306-us58wwmp 2165 8 to to IN cord-015306-us58wwmp 2165 9 FOXP3 FOXP3 NNS cord-015306-us58wwmp 2165 10 gene gene NN cord-015306-us58wwmp 2165 11 on on IN cord-015306-us58wwmp 2165 12 the the DT cord-015306-us58wwmp 2165 13 X x NN cord-015306-us58wwmp 2165 14 chromosome chromosome NN cord-015306-us58wwmp 2165 15 ( ( -LRB- cord-015306-us58wwmp 2165 16 Xp11.23-q13.3 xp11.23-q13.3 NN cord-015306-us58wwmp 2165 17 ) ) -RRB- cord-015306-us58wwmp 2165 18 . . . cord-015306-us58wwmp 2166 1 It -PRON- PRP cord-015306-us58wwmp 2166 2 seems seem VBZ cord-015306-us58wwmp 2166 3 that that IN cord-015306-us58wwmp 2166 4 in in IN cord-015306-us58wwmp 2166 5 this this DT cord-015306-us58wwmp 2166 6 sibling sibling NN cord-015306-us58wwmp 2166 7 mutations mutation NNS cord-015306-us58wwmp 2166 8 occurred occur VBD cord-015306-us58wwmp 2166 9 in in IN cord-015306-us58wwmp 2166 10 exons exon NNS cord-015306-us58wwmp 2166 11 of of IN cord-015306-us58wwmp 2166 12 both both DT cord-015306-us58wwmp 2166 13 of of IN cord-015306-us58wwmp 2166 14 these these DT cord-015306-us58wwmp 2166 15 genes gene NNS cord-015306-us58wwmp 2166 16 . . . cord-015306-us58wwmp 2167 1 This this DT cord-015306-us58wwmp 2167 2 case case NN cord-015306-us58wwmp 2167 3 is be VBZ cord-015306-us58wwmp 2167 4 to to TO cord-015306-us58wwmp 2167 5 remind remind VB cord-015306-us58wwmp 2167 6 on on IN cord-015306-us58wwmp 2167 7 pleomorphic pleomorphic JJ cord-015306-us58wwmp 2167 8 potential potential NN cord-015306-us58wwmp 2167 9 of of IN cord-015306-us58wwmp 2167 10 mutations mutation NNS cord-015306-us58wwmp 2167 11 that that WDT cord-015306-us58wwmp 2167 12 occur occur VBP cord-015306-us58wwmp 2167 13 near near IN cord-015306-us58wwmp 2167 14 the the DT cord-015306-us58wwmp 2167 15 coding code VBG cord-015306-us58wwmp 2167 16 regions region NNS cord-015306-us58wwmp 2167 17 of of IN cord-015306-us58wwmp 2167 18 the the DT cord-015306-us58wwmp 2167 19 FOXP3 FOXP3 NNP cord-015306-us58wwmp 2167 20 gene gene NN cord-015306-us58wwmp 2167 21 . . . cord-015306-us58wwmp 2168 1 Objective objective NN cord-015306-us58wwmp 2168 2 : : : cord-015306-us58wwmp 2169 1 multiple multiple JJ cord-015306-us58wwmp 2169 2 target target NN cord-015306-us58wwmp 2169 3 organ organ NN cord-015306-us58wwmp 2169 4 defects defect NNS cord-015306-us58wwmp 2169 5 ( ( -LRB- cord-015306-us58wwmp 2169 6 MTOD MTOD NNP cord-015306-us58wwmp 2169 7 ) ) -RRB- cord-015306-us58wwmp 2169 8 is be VBZ cord-015306-us58wwmp 2169 9 a a DT cord-015306-us58wwmp 2169 10 subgroup subgroup NN cord-015306-us58wwmp 2169 11 of of IN cord-015306-us58wwmp 2169 12 pseudohypoaldosteronism pseudohypoaldosteronism NN cord-015306-us58wwmp 2170 1 ( ( -LRB- cord-015306-us58wwmp 2170 2 PHA PHA NNP cord-015306-us58wwmp 2170 3 ) ) -RRB- cord-015306-us58wwmp 2170 4 type type NN cord-015306-us58wwmp 2170 5 I -PRON- PRP cord-015306-us58wwmp 2170 6 and and CC cord-015306-us58wwmp 2170 7 salt salt NN cord-015306-us58wwmp 2170 8 wasting wasting NN cord-015306-us58wwmp 2170 9 is be VBZ cord-015306-us58wwmp 2170 10 more more RBR cord-015306-us58wwmp 2170 11 severe severe JJ cord-015306-us58wwmp 2170 12 in in IN cord-015306-us58wwmp 2170 13 this this DT cord-015306-us58wwmp 2170 14 form form NN cord-015306-us58wwmp 2170 15 of of IN cord-015306-us58wwmp 2171 1 PHA PHA NNP cord-015306-us58wwmp 2171 2 I. I. NNP cord-015306-us58wwmp 2171 3 It -PRON- PRP cord-015306-us58wwmp 2171 4 has have VBZ cord-015306-us58wwmp 2171 5 a a DT cord-015306-us58wwmp 2171 6 poorer poor JJR cord-015306-us58wwmp 2171 7 outcome outcome NN cord-015306-us58wwmp 2171 8 than than IN cord-015306-us58wwmp 2171 9 the the DT cord-015306-us58wwmp 2171 10 renal renal JJ cord-015306-us58wwmp 2171 11 form form NN cord-015306-us58wwmp 2171 12 , , , cord-015306-us58wwmp 2171 13 and and CC cord-015306-us58wwmp 2171 14 therapy therapy NN cord-015306-us58wwmp 2171 15 must must MD cord-015306-us58wwmp 2171 16 be be VB cord-015306-us58wwmp 2171 17 maintained maintain VBN cord-015306-us58wwmp 2171 18 throughout throughout IN cord-015306-us58wwmp 2171 19 life life NN cord-015306-us58wwmp 2171 20 . . . cord-015306-us58wwmp 2172 1 Here here RB cord-015306-us58wwmp 2172 2 , , , cord-015306-us58wwmp 2172 3 we -PRON- PRP cord-015306-us58wwmp 2172 4 reported report VBD cord-015306-us58wwmp 2172 5 an an DT cord-015306-us58wwmp 2172 6 infant infant NN cord-015306-us58wwmp 2172 7 with with IN cord-015306-us58wwmp 2172 8 MTOD MTOD NNP cord-015306-us58wwmp 2172 9 who who WP cord-015306-us58wwmp 2172 10 had have VBD cord-015306-us58wwmp 2172 11 severe severe JJ cord-015306-us58wwmp 2172 12 hyperkalemia hyperkalemia NN cord-015306-us58wwmp 2172 13 resistant resistant JJ cord-015306-us58wwmp 2172 14 to to IN cord-015306-us58wwmp 2172 15 classical classical JJ cord-015306-us58wwmp 2172 16 treatment treatment NN cord-015306-us58wwmp 2172 17 of of IN cord-015306-us58wwmp 2172 18 PHA PHA NNP cord-015306-us58wwmp 2172 19 . . . cord-015306-us58wwmp 2173 1 Hyperkalemia Hyperkalemia NNP cord-015306-us58wwmp 2173 2 was be VBD cord-015306-us58wwmp 2173 3 normalized normalize VBN cord-015306-us58wwmp 2173 4 only only RB cord-015306-us58wwmp 2173 5 by by IN cord-015306-us58wwmp 2173 6 peritoneal peritoneal JJ cord-015306-us58wwmp 2173 7 dialysis dialysis NN cord-015306-us58wwmp 2173 8 ( ( -LRB- cord-015306-us58wwmp 2173 9 PD PD NNP cord-015306-us58wwmp 2173 10 ) ) -RRB- cord-015306-us58wwmp 2173 11 . . . cord-015306-us58wwmp 2174 1 Case case NN cord-015306-us58wwmp 2174 2 : : : cord-015306-us58wwmp 2175 1 A a DT cord-015306-us58wwmp 2175 2 4 4 CD cord-015306-us58wwmp 2175 3 month month NN cord-015306-us58wwmp 2175 4 - - HYPH cord-015306-us58wwmp 2175 5 old old JJ cord-015306-us58wwmp 2175 6 boy boy NN cord-015306-us58wwmp 2175 7 was be VBD cord-015306-us58wwmp 2175 8 admitted admit VBN cord-015306-us58wwmp 2175 9 to to IN cord-015306-us58wwmp 2175 10 our -PRON- PRP$ cord-015306-us58wwmp 2175 11 hospital hospital NN cord-015306-us58wwmp 2175 12 with with IN cord-015306-us58wwmp 2175 13 persistent persistent JJ cord-015306-us58wwmp 2175 14 vomiting vomiting NN cord-015306-us58wwmp 2175 15 , , , cord-015306-us58wwmp 2175 16 metabolic metabolic JJ cord-015306-us58wwmp 2175 17 acidosis acidosis NN cord-015306-us58wwmp 2175 18 , , , cord-015306-us58wwmp 2175 19 and and CC cord-015306-us58wwmp 2175 20 severe severe JJ cord-015306-us58wwmp 2175 21 hyperkalemia hyperkalemia NN cord-015306-us58wwmp 2175 22 . . . cord-015306-us58wwmp 2176 1 There there EX cord-015306-us58wwmp 2176 2 was be VBD cord-015306-us58wwmp 2176 3 consanguinity consanguinity NN cord-015306-us58wwmp 2176 4 between between IN cord-015306-us58wwmp 2176 5 parents parent NNS cord-015306-us58wwmp 2176 6 and and CC cord-015306-us58wwmp 2176 7 he -PRON- PRP cord-015306-us58wwmp 2176 8 had have VBD cord-015306-us58wwmp 2176 9 a a DT cord-015306-us58wwmp 2176 10 healthy healthy JJ cord-015306-us58wwmp 2176 11 sister sister NN cord-015306-us58wwmp 2176 12 and and CC cord-015306-us58wwmp 2176 13 brother brother NN cord-015306-us58wwmp 2176 14 . . . cord-015306-us58wwmp 2177 1 There there EX cord-015306-us58wwmp 2177 2 was be VBD cord-015306-us58wwmp 2177 3 no no DT cord-015306-us58wwmp 2177 4 history history NN cord-015306-us58wwmp 2177 5 of of IN cord-015306-us58wwmp 2177 6 medication medication NN cord-015306-us58wwmp 2177 7 . . . cord-015306-us58wwmp 2178 1 Physical physical JJ cord-015306-us58wwmp 2178 2 examination examination NN cord-015306-us58wwmp 2178 3 revealed reveal VBD cord-015306-us58wwmp 2178 4 the the DT cord-015306-us58wwmp 2178 5 signs sign NNS cord-015306-us58wwmp 2178 6 of of IN cord-015306-us58wwmp 2178 7 volume volume NN cord-015306-us58wwmp 2178 8 depletion depletion NN cord-015306-us58wwmp 2178 9 and and CC cord-015306-us58wwmp 2178 10 acidosis acidosis NN cord-015306-us58wwmp 2178 11 . . . cord-015306-us58wwmp 2179 1 Results result NNS cord-015306-us58wwmp 2179 2 : : : cord-015306-us58wwmp 2180 1 In in IN cord-015306-us58wwmp 2180 2 laboratory laboratory NN cord-015306-us58wwmp 2180 3 examination examination NN cord-015306-us58wwmp 2180 4 , , , cord-015306-us58wwmp 2180 5 blood blood NN cord-015306-us58wwmp 2180 6 urea urea NN cord-015306-us58wwmp 2180 7 nitrogen nitrogen NN cord-015306-us58wwmp 2180 8 was be VBD cord-015306-us58wwmp 2180 9 71 71 CD cord-015306-us58wwmp 2180 10 mg mg NNP cord-015306-us58wwmp 2180 11 / / SYM cord-015306-us58wwmp 2180 12 dl dl NNP cord-015306-us58wwmp 2180 13 , , , cord-015306-us58wwmp 2180 14 creatinine creatinine NN cord-015306-us58wwmp 2180 15 0.43 0.43 CD cord-015306-us58wwmp 2180 16 mg mg NNP cord-015306-us58wwmp 2180 17 / / SYM cord-015306-us58wwmp 2180 18 dl dl NNP cord-015306-us58wwmp 2180 19 , , , cord-015306-us58wwmp 2180 20 sodium sodium NN cord-015306-us58wwmp 2180 21 114mEq 114mEq NNP cord-015306-us58wwmp 2180 22 / / SYM cord-015306-us58wwmp 2180 23 L l NN cord-015306-us58wwmp 2180 24 , , , cord-015306-us58wwmp 2180 25 potassium potassium NN cord-015306-us58wwmp 2180 26 9.5mEq 9.5meq CD cord-015306-us58wwmp 2180 27 / / SYM cord-015306-us58wwmp 2180 28 L l NN cord-015306-us58wwmp 2180 29 , , , cord-015306-us58wwmp 2180 30 and and CC cord-015306-us58wwmp 2181 1 chloride chloride NNP cord-015306-us58wwmp 2181 2 97mEq 97mEq NNP cord-015306-us58wwmp 2181 3 / / SYM cord-015306-us58wwmp 2181 4 L. L. NNP cord-015306-us58wwmp 2181 5 Blood Blood NNP cord-015306-us58wwmp 2181 6 pH pH NNP cord-015306-us58wwmp 2181 7 was be VBD cord-015306-us58wwmp 2181 8 7.33 7.33 CD cord-015306-us58wwmp 2181 9 , , , cord-015306-us58wwmp 2181 10 base base JJ cord-015306-us58wwmp 2181 11 excess excess JJ cord-015306-us58wwmp 2181 12 -12mEq -12mEq NNS cord-015306-us58wwmp 2181 13 / / SYM cord-015306-us58wwmp 2181 14 L L NNP cord-015306-us58wwmp 2181 15 , , , cord-015306-us58wwmp 2181 16 and and CC cord-015306-us58wwmp 2181 17 HCO3 HCO3 NNP cord-015306-us58wwmp 2181 18 11mEq 11mEq NNP cord-015306-us58wwmp 2181 19 / / SYM cord-015306-us58wwmp 2181 20 L. L. NNP cord-015306-us58wwmp 2181 21 Urinary urinary JJ cord-015306-us58wwmp 2181 22 analysis analysis NN cord-015306-us58wwmp 2181 23 revealed reveal VBD cord-015306-us58wwmp 2181 24 low low JJ cord-015306-us58wwmp 2181 25 specific specific JJ cord-015306-us58wwmp 2181 26 gravity gravity NN cord-015306-us58wwmp 2181 27 ( ( -LRB- cord-015306-us58wwmp 2181 28 1003 1003 CD cord-015306-us58wwmp 2181 29 ) ) -RRB- cord-015306-us58wwmp 2181 30 with with IN cord-015306-us58wwmp 2181 31 pH pH NNP cord-015306-us58wwmp 2181 32 8.0 8.0 CD cord-015306-us58wwmp 2181 33 , , , cord-015306-us58wwmp 2181 34 and and CC cord-015306-us58wwmp 2181 35 normal normal JJ cord-015306-us58wwmp 2181 36 urinary urinary JJ cord-015306-us58wwmp 2181 37 sediment sediment NN cord-015306-us58wwmp 2181 38 . . . cord-015306-us58wwmp 2182 1 Urinary urinary JJ cord-015306-us58wwmp 2182 2 sodium sodium NN cord-015306-us58wwmp 2182 3 was be VBD cord-015306-us58wwmp 2182 4 68mEq 68meq CD cord-015306-us58wwmp 2182 5 / / SYM cord-015306-us58wwmp 2182 6 L L NNP cord-015306-us58wwmp 2182 7 , , , cord-015306-us58wwmp 2182 8 potassium potassium NN cord-015306-us58wwmp 2182 9 1mEq 1meq CD cord-015306-us58wwmp 2182 10 / / SYM cord-015306-us58wwmp 2182 11 L l NN cord-015306-us58wwmp 2182 12 , , , cord-015306-us58wwmp 2182 13 and and CC cord-015306-us58wwmp 2182 14 plasma plasma NN cord-015306-us58wwmp 2182 15 renin renin NN cord-015306-us58wwmp 2182 16 activity activity NN cord-015306-us58wwmp 2182 17 80.2ng 80.2ng CD cord-015306-us58wwmp 2182 18 / / SYM cord-015306-us58wwmp 2182 19 ml ml NN cord-015306-us58wwmp 2182 20 ( ( -LRB- cord-015306-us58wwmp 2182 21 2.7 2.7 CD cord-015306-us58wwmp 2182 22 - - SYM cord-015306-us58wwmp 2182 23 37.0 37.0 CD cord-015306-us58wwmp 2182 24 ) ) -RRB- cord-015306-us58wwmp 2182 25 , , , cord-015306-us58wwmp 2182 26 aldosterone aldosterone NNP cord-015306-us58wwmp 2182 27 2800pg 2800pg NNP cord-015306-us58wwmp 2183 1 /ml /ml . cord-015306-us58wwmp 2183 2 ( ( -LRB- cord-015306-us58wwmp 2183 3 50 50 CD cord-015306-us58wwmp 2183 4 - - SYM cord-015306-us58wwmp 2183 5 900 900 CD cord-015306-us58wwmp 2183 6 ) ) -RRB- cord-015306-us58wwmp 2183 7 , , , cord-015306-us58wwmp 2183 8 cortisol cortisol NN cord-015306-us58wwmp 2183 9 11.1 11.1 CD cord-015306-us58wwmp 2183 10 mg mg NNP cord-015306-us58wwmp 2183 11 / / SYM cord-015306-us58wwmp 2183 12 dl dl NNP cord-015306-us58wwmp 2183 13 ( ( -LRB- cord-015306-us58wwmp 2183 14 7 7 CD cord-015306-us58wwmp 2183 15 - - SYM cord-015306-us58wwmp 2183 16 17.5 17.5 CD cord-015306-us58wwmp 2183 17 ) ) -RRB- cord-015306-us58wwmp 2183 18 , , , cord-015306-us58wwmp 2183 19 and and CC cord-015306-us58wwmp 2183 20 ACTH ACTH NNP cord-015306-us58wwmp 2183 21 5.5pg 5.5pg CD cord-015306-us58wwmp 2184 1 /ml /ml . cord-015306-us58wwmp 2184 2 ( ( -LRB- cord-015306-us58wwmp 2184 3 10 10 CD cord-015306-us58wwmp 2184 4 - - SYM cord-015306-us58wwmp 2184 5 469 469 CD cord-015306-us58wwmp 2184 6 ) ) -RRB- cord-015306-us58wwmp 2184 7 . . . cord-015306-us58wwmp 2185 1 Renal renal JJ cord-015306-us58wwmp 2185 2 ultrasonography ultrasonography NN cord-015306-us58wwmp 2185 3 did do VBD cord-015306-us58wwmp 2185 4 not not RB cord-015306-us58wwmp 2185 5 show show VB cord-015306-us58wwmp 2185 6 any any DT cord-015306-us58wwmp 2185 7 abnormalities abnormality NNS cord-015306-us58wwmp 2185 8 . . . cord-015306-us58wwmp 2186 1 Sweet sweet JJ cord-015306-us58wwmp 2186 2 - - HYPH cord-015306-us58wwmp 2186 3 test test NN cord-015306-us58wwmp 2186 4 showed show VBD cord-015306-us58wwmp 2186 5 high high JJ cord-015306-us58wwmp 2186 6 sodium sodium NN cord-015306-us58wwmp 2186 7 waste waste NN cord-015306-us58wwmp 2186 8 from from IN cord-015306-us58wwmp 2186 9 sweet sweet JJ cord-015306-us58wwmp 2186 10 glands gland NNS cord-015306-us58wwmp 2186 11 ( ( -LRB- cord-015306-us58wwmp 2186 12 144mEq 144meq CD cord-015306-us58wwmp 2186 13 / / SYM cord-015306-us58wwmp 2186 14 L l NN cord-015306-us58wwmp 2186 15 ) ) -RRB- cord-015306-us58wwmp 2186 16 . . . cord-015306-us58wwmp 2187 1 The the DT cord-015306-us58wwmp 2187 2 patient patient NN cord-015306-us58wwmp 2187 3 diagnosed diagnose VBN cord-015306-us58wwmp 2187 4 as as IN cord-015306-us58wwmp 2187 5 MTOD MTOD NNP cord-015306-us58wwmp 2187 6 . . . cord-015306-us58wwmp 2188 1 Severe severe JJ cord-015306-us58wwmp 2188 2 hyperkalemia hyperkalemia NN cord-015306-us58wwmp 2188 3 persisted persist VBD cord-015306-us58wwmp 2188 4 and and CC cord-015306-us58wwmp 2188 5 was be VBD cord-015306-us58wwmp 2188 6 resistant resistant JJ cord-015306-us58wwmp 2188 7 to to IN cord-015306-us58wwmp 2188 8 all all DT cord-015306-us58wwmp 2188 9 treatment treatment NN cord-015306-us58wwmp 2188 10 options option NNS cord-015306-us58wwmp 2188 11 for for IN cord-015306-us58wwmp 2188 12 PHA PHA NNP cord-015306-us58wwmp 2188 13 , , , cord-015306-us58wwmp 2188 14 including include VBG cord-015306-us58wwmp 2188 15 high high JJ cord-015306-us58wwmp 2188 16 - - HYPH cord-015306-us58wwmp 2188 17 sodium sodium NN cord-015306-us58wwmp 2188 18 and and CC cord-015306-us58wwmp 2188 19 low low JJ cord-015306-us58wwmp 2188 20 - - HYPH cord-015306-us58wwmp 2188 21 potassium potassium NN cord-015306-us58wwmp 2188 22 diet diet NN cord-015306-us58wwmp 2188 23 , , , cord-015306-us58wwmp 2188 24 fluid fluid JJ cord-015306-us58wwmp 2188 25 resuscitation resuscitation NN cord-015306-us58wwmp 2188 26 , , , cord-015306-us58wwmp 2188 27 potassiumbinding potassiumbinding NN cord-015306-us58wwmp 2188 28 resins resin NNS cord-015306-us58wwmp 2188 29 , , , cord-015306-us58wwmp 2188 30 indomethacin indomethacin NN cord-015306-us58wwmp 2188 31 , , , cord-015306-us58wwmp 2188 32 fludrocortisone fludrocortisone NNP cord-015306-us58wwmp 2188 33 , , , cord-015306-us58wwmp 2188 34 and and CC cord-015306-us58wwmp 2188 35 hydrochlorothiazide hydrochlorothiazide NN cord-015306-us58wwmp 2188 36 . . . cord-015306-us58wwmp 2189 1 Nutritional nutritional JJ cord-015306-us58wwmp 2189 2 status status NN cord-015306-us58wwmp 2189 3 of of IN cord-015306-us58wwmp 2189 4 the the DT cord-015306-us58wwmp 2189 5 patient patient NN cord-015306-us58wwmp 2189 6 was be VBD cord-015306-us58wwmp 2189 7 also also RB cord-015306-us58wwmp 2189 8 not not RB cord-015306-us58wwmp 2189 9 good good JJ cord-015306-us58wwmp 2189 10 , , , cord-015306-us58wwmp 2189 11 and and CC cord-015306-us58wwmp 2189 12 parents parent NNS cord-015306-us58wwmp 2189 13 did do VBD cord-015306-us58wwmp 2189 14 not not RB cord-015306-us58wwmp 2189 15 accept accept VB cord-015306-us58wwmp 2189 16 gastrostomy gastrostomy NN cord-015306-us58wwmp 2189 17 . . . cord-015306-us58wwmp 2190 1 Hyperkalemia Hyperkalemia NNP cord-015306-us58wwmp 2190 2 was be VBD cord-015306-us58wwmp 2190 3 corrected correct VBN cord-015306-us58wwmp 2190 4 only only RB cord-015306-us58wwmp 2190 5 after after IN cord-015306-us58wwmp 2190 6 PD PD NNP cord-015306-us58wwmp 2190 7 treatment treatment NN cord-015306-us58wwmp 2190 8 , , , cord-015306-us58wwmp 2190 9 and and CC cord-015306-us58wwmp 2190 10 his -PRON- PRP$ cord-015306-us58wwmp 2190 11 nutritional nutritional JJ cord-015306-us58wwmp 2190 12 status status NN cord-015306-us58wwmp 2190 13 improved improve VBN cord-015306-us58wwmp 2190 14 dramatically dramatically RB cord-015306-us58wwmp 2190 15 . . . cord-015306-us58wwmp 2191 1 Conclusion conclusion NN cord-015306-us58wwmp 2191 2 : : : cord-015306-us58wwmp 2192 1 In in IN cord-015306-us58wwmp 2192 2 the the DT cord-015306-us58wwmp 2192 3 case case NN cord-015306-us58wwmp 2192 4 of of IN cord-015306-us58wwmp 2192 5 type type NN cord-015306-us58wwmp 2192 6 IV IV NNP cord-015306-us58wwmp 2192 7 renal renal JJ cord-015306-us58wwmp 2192 8 tubular tubular JJ cord-015306-us58wwmp 2192 9 acidosis acidosis NN cord-015306-us58wwmp 2192 10 resistant resistant JJ cord-015306-us58wwmp 2192 11 to to IN cord-015306-us58wwmp 2192 12 therapy therapy NN cord-015306-us58wwmp 2192 13 , , , cord-015306-us58wwmp 2192 14 MTOD MTOD NNP cord-015306-us58wwmp 2192 15 could could MD cord-015306-us58wwmp 2192 16 be be VB cord-015306-us58wwmp 2192 17 considered consider VBN cord-015306-us58wwmp 2192 18 as as IN cord-015306-us58wwmp 2192 19 a a DT cord-015306-us58wwmp 2192 20 cause cause NN cord-015306-us58wwmp 2192 21 of of IN cord-015306-us58wwmp 2192 22 acidosis acidosis NN cord-015306-us58wwmp 2192 23 . . . cord-015306-us58wwmp 2193 1 If if IN cord-015306-us58wwmp 2193 2 the the DT cord-015306-us58wwmp 2193 3 classical classical JJ cord-015306-us58wwmp 2193 4 treatment treatment NN cord-015306-us58wwmp 2193 5 options option NNS cord-015306-us58wwmp 2193 6 fail fail VBP cord-015306-us58wwmp 2193 7 to to TO cord-015306-us58wwmp 2193 8 correct correct VB cord-015306-us58wwmp 2193 9 hyperkalemia hyperkalemia NN cord-015306-us58wwmp 2193 10 in in IN cord-015306-us58wwmp 2193 11 these these DT cord-015306-us58wwmp 2193 12 patients patient NNS cord-015306-us58wwmp 2193 13 , , , cord-015306-us58wwmp 2193 14 PD PD NNP cord-015306-us58wwmp 2193 15 may may MD cord-015306-us58wwmp 2193 16 be be VB cord-015306-us58wwmp 2193 17 a a DT cord-015306-us58wwmp 2193 18 reasonable reasonable JJ cord-015306-us58wwmp 2193 19 choice choice NN cord-015306-us58wwmp 2193 20 to to TO cord-015306-us58wwmp 2193 21 normalize normalize VB cord-015306-us58wwmp 2193 22 severe severe JJ cord-015306-us58wwmp 2193 23 hyperkalemia hyperkalemia NN cord-015306-us58wwmp 2193 24 . . . cord-015306-us58wwmp 2194 1 Gülsün Gülsün NNP cord-015306-us58wwmp 2194 2 Gülay Gülay NNP cord-015306-us58wwmp 2194 3 Yılmaz Yılmaz NNP cord-015306-us58wwmp 2194 4 1 1 CD cord-015306-us58wwmp 2194 5 Erta Erta NNP cord-015306-us58wwmp 2194 6 Yilmaz Yilmaz NNP cord-015306-us58wwmp 2194 7 1 1 CD cord-015306-us58wwmp 2194 8 , , , cord-015306-us58wwmp 2194 9 2 2 CD cord-015306-us58wwmp 2194 10 1 1 CD cord-015306-us58wwmp 2194 11 Pediatric Pediatric NNP cord-015306-us58wwmp 2194 12 Nephrology Nephrology NNP cord-015306-us58wwmp 2194 13 , , , cord-015306-us58wwmp 2194 14 MD MD NNP cord-015306-us58wwmp 2194 15 , , , cord-015306-us58wwmp 2194 16 Antalya Antalya NNP cord-015306-us58wwmp 2194 17 , , , cord-015306-us58wwmp 2194 18 Turkey Turkey NNP cord-015306-us58wwmp 2194 19 2 2 CD cord-015306-us58wwmp 2194 20 Akdeniz Akdeniz NNP cord-015306-us58wwmp 2194 21 Univercity Univercity NNP cord-015306-us58wwmp 2194 22 , , , cord-015306-us58wwmp 2195 1 Prof. Prof. NNP cord-015306-us58wwmp 2195 2 Dr Dr NNP cord-015306-us58wwmp 2195 3 , , , cord-015306-us58wwmp 2195 4 Antalya Antalya NNP cord-015306-us58wwmp 2195 5 , , , cord-015306-us58wwmp 2196 1 Turkey Turkey NNP cord-015306-us58wwmp 2196 2 Tuberous Tuberous NNP cord-015306-us58wwmp 2196 3 sclerosis sclerosis NN cord-015306-us58wwmp 2196 4 , , , cord-015306-us58wwmp 2196 5 which which WDT cord-015306-us58wwmp 2196 6 has have VBZ cord-015306-us58wwmp 2196 7 an an DT cord-015306-us58wwmp 2196 8 autosomal autosomal JJ cord-015306-us58wwmp 2196 9 dominant dominant JJ cord-015306-us58wwmp 2196 10 hereditary hereditary JJ cord-015306-us58wwmp 2196 11 disease disease NN cord-015306-us58wwmp 2196 12 with with IN cord-015306-us58wwmp 2196 13 a a DT cord-015306-us58wwmp 2196 14 high high JJ cord-015306-us58wwmp 2196 15 rate rate NN cord-015306-us58wwmp 2196 16 of of IN cord-015306-us58wwmp 2196 17 spotaneous spotaneous JJ cord-015306-us58wwmp 2196 18 mutation mutation NN cord-015306-us58wwmp 2196 19 , , , cord-015306-us58wwmp 2196 20 especially especially RB cord-015306-us58wwmp 2196 21 occupies occupy VBZ cord-015306-us58wwmp 2196 22 the the DT cord-015306-us58wwmp 2196 23 nervous nervous JJ cord-015306-us58wwmp 2196 24 system system NN cord-015306-us58wwmp 2196 25 and and CC cord-015306-us58wwmp 2196 26 many many JJ cord-015306-us58wwmp 2196 27 other other JJ cord-015306-us58wwmp 2196 28 organs organ NNS cord-015306-us58wwmp 2196 29 like like IN cord-015306-us58wwmp 2196 30 kidney kidney NN cord-015306-us58wwmp 2196 31 , , , cord-015306-us58wwmp 2196 32 heart heart NN cord-015306-us58wwmp 2196 33 and and CC cord-015306-us58wwmp 2196 34 lung lung NN cord-015306-us58wwmp 2196 35 . . . cord-015306-us58wwmp 2197 1 The the DT cord-015306-us58wwmp 2197 2 case case NN cord-015306-us58wwmp 2197 3 presented present VBN cord-015306-us58wwmp 2197 4 here here RB cord-015306-us58wwmp 2197 5 was be VBD cord-015306-us58wwmp 2197 6 initially initially RB cord-015306-us58wwmp 2197 7 diagnosed diagnose VBN cord-015306-us58wwmp 2197 8 as as IN cord-015306-us58wwmp 2197 9 congenital congenital JJ cord-015306-us58wwmp 2197 10 heart heart NN cord-015306-us58wwmp 2197 11 and and CC cord-015306-us58wwmp 2197 12 polycycystic polycycystic JJ cord-015306-us58wwmp 2197 13 kidney kidney NN cord-015306-us58wwmp 2197 14 diasease diasease NNP cord-015306-us58wwmp 2197 15 , , , cord-015306-us58wwmp 2197 16 because because IN cord-015306-us58wwmp 2197 17 of of IN cord-015306-us58wwmp 2197 18 its -PRON- PRP$ cord-015306-us58wwmp 2197 19 characteristics characteristic NNS cord-015306-us58wwmp 2197 20 which which WDT cord-015306-us58wwmp 2197 21 were be VBD cord-015306-us58wwmp 2197 22 quite quite RB cord-015306-us58wwmp 2197 23 different different JJ cord-015306-us58wwmp 2197 24 than than IN cord-015306-us58wwmp 2197 25 expected expect VBN cord-015306-us58wwmp 2197 26 for for IN cord-015306-us58wwmp 2197 27 tuberous tuberous JJ cord-015306-us58wwmp 2197 28 sclerosis sclerosis NN cord-015306-us58wwmp 2197 29 . . . cord-015306-us58wwmp 2198 1 Finally finally RB cord-015306-us58wwmp 2198 2 , , , cord-015306-us58wwmp 2198 3 it -PRON- PRP cord-015306-us58wwmp 2198 4 was be VBD cord-015306-us58wwmp 2198 5 evaluated evaluate VBN cord-015306-us58wwmp 2198 6 at at IN cord-015306-us58wwmp 2198 7 our -PRON- PRP$ cord-015306-us58wwmp 2198 8 pediatric pediatric JJ cord-015306-us58wwmp 2198 9 department department NN cord-015306-us58wwmp 2198 10 together together RB cord-015306-us58wwmp 2198 11 with with IN cord-015306-us58wwmp 2198 12 its -PRON- PRP$ cord-015306-us58wwmp 2198 13 dermatological dermatological JJ cord-015306-us58wwmp 2198 14 and and CC cord-015306-us58wwmp 2198 15 radiological radiological JJ cord-015306-us58wwmp 2198 16 aspects aspect NNS cord-015306-us58wwmp 2198 17 and and CC cord-015306-us58wwmp 2198 18 defined define VBN cord-015306-us58wwmp 2198 19 as as IN cord-015306-us58wwmp 2198 20 a a DT cord-015306-us58wwmp 2198 21 tuberous tuberous JJ cord-015306-us58wwmp 2198 22 sclerosis sclerosis NN cord-015306-us58wwmp 2198 23 of of IN cord-015306-us58wwmp 2198 24 delateddiagnosis delateddiagnosis NNP cord-015306-us58wwmp 2198 25 . . . cord-015306-us58wwmp 2199 1 The the DT cord-015306-us58wwmp 2199 2 case case NN cord-015306-us58wwmp 2199 3 was be VBD cord-015306-us58wwmp 2199 4 discussed discuss VBN cord-015306-us58wwmp 2199 5 with with IN cord-015306-us58wwmp 2199 6 its -PRON- PRP$ cord-015306-us58wwmp 2199 7 former former JJ cord-015306-us58wwmp 2199 8 and and CC cord-015306-us58wwmp 2199 9 actual actual JJ cord-015306-us58wwmp 2199 10 findings finding NNS cord-015306-us58wwmp 2199 11 and and CC cord-015306-us58wwmp 2199 12 presented present VBN cord-015306-us58wwmp 2199 13 as as IN cord-015306-us58wwmp 2199 14 a a DT cord-015306-us58wwmp 2199 15 warning warning NN cord-015306-us58wwmp 2199 16 for for IN cord-015306-us58wwmp 2199 17 early early JJ cord-015306-us58wwmp 2199 18 diagnosis diagnosis NN cord-015306-us58wwmp 2199 19 . . . cord-015306-us58wwmp 2200 1 Abstract abstract JJ cord-015306-us58wwmp 2200 2 # # NN cord-015306-us58wwmp 2201 1 P p NN cord-015306-us58wwmp 2201 2 - - HYPH cord-015306-us58wwmp 2201 3 SAT285 sat285 JJ cord-015306-us58wwmp 2202 1 The the DT cord-015306-us58wwmp 2202 2 effect effect NN cord-015306-us58wwmp 2202 3 of of IN cord-015306-us58wwmp 2202 4 bone bone NN cord-015306-us58wwmp 2202 5 marrow marrow NN cord-015306-us58wwmp 2202 6 stem stem NN cord-015306-us58wwmp 2202 7 cells cell NNS cord-015306-us58wwmp 2202 8 mobilization mobilization NN cord-015306-us58wwmp 2202 9 on on IN cord-015306-us58wwmp 2202 10 expression expression NN cord-015306-us58wwmp 2202 11 of of IN cord-015306-us58wwmp 2202 12 HIF-1α HIF-1α NNP cord-015306-us58wwmp 2202 13 and and CC cord-015306-us58wwmp 2202 14 EGF EGF NNP cord-015306-us58wwmp 2202 15 in in IN cord-015306-us58wwmp 2202 16 ischemia ischemia NN cord-015306-us58wwmp 2202 17 / / SYM cord-015306-us58wwmp 2202 18 reperfusion reperfusion NN cord-015306-us58wwmp 2202 19 - - HYPH cord-015306-us58wwmp 2202 20 induced induce VBN cord-015306-us58wwmp 2202 21 renal renal JJ cord-015306-us58wwmp 2202 22 injury injury NN cord-015306-us58wwmp 2202 23 Objective objective NN cord-015306-us58wwmp 2202 24 : : : cord-015306-us58wwmp 2202 25 To to TO cord-015306-us58wwmp 2202 26 investigate investigate VB cord-015306-us58wwmp 2202 27 the the DT cord-015306-us58wwmp 2202 28 therapeutic therapeutic JJ cord-015306-us58wwmp 2202 29 effects effect NNS cord-015306-us58wwmp 2202 30 of of IN cord-015306-us58wwmp 2202 31 bone bone NN cord-015306-us58wwmp 2202 32 marrow marrow NN cord-015306-us58wwmp 2202 33 stem stem NN cord-015306-us58wwmp 2202 34 cells cell NNS cord-015306-us58wwmp 2202 35 which which WDT cord-015306-us58wwmp 2202 36 has have VBZ cord-015306-us58wwmp 2202 37 been be VBN cord-015306-us58wwmp 2202 38 mobilized mobilize VBN cord-015306-us58wwmp 2202 39 by by IN cord-015306-us58wwmp 2202 40 G G NNP cord-015306-us58wwmp 2202 41 - - HYPH cord-015306-us58wwmp 2202 42 CSF CSF NNP cord-015306-us58wwmp 2202 43 and and CC cord-015306-us58wwmp 2202 44 stem stem VB cord-015306-us58wwmp 2202 45 SCF SCF NNS cord-015306-us58wwmp 2202 46 on on IN cord-015306-us58wwmp 2202 47 expression expression NN cord-015306-us58wwmp 2202 48 of of IN cord-015306-us58wwmp 2202 49 acute acute JJ cord-015306-us58wwmp 2202 50 tubular tubular JJ cord-015306-us58wwmp 2202 51 necrosis necrosis NN cord-015306-us58wwmp 2202 52 hypoxia hypoxia NN cord-015306-us58wwmp 2202 53 inducible inducible JJ cord-015306-us58wwmp 2202 54 factor-1a factor-1a NNP cord-015306-us58wwmp 2202 55 ( ( -LRB- cord-015306-us58wwmp 2202 56 HIF-1α HIF-1α NNP cord-015306-us58wwmp 2202 57 ) ) -RRB- cord-015306-us58wwmp 2202 58 and and CC cord-015306-us58wwmp 2202 59 epidermal epidermal JJ cord-015306-us58wwmp 2202 60 growth growth NN cord-015306-us58wwmp 2202 61 factor factor NN cord-015306-us58wwmp 2202 62 ( ( -LRB- cord-015306-us58wwmp 2202 63 EGF EGF NNP cord-015306-us58wwmp 2202 64 ) ) -RRB- cord-015306-us58wwmp 2202 65 , , , cord-015306-us58wwmp 2202 66 and and CC cord-015306-us58wwmp 2202 67 to to TO cord-015306-us58wwmp 2202 68 investigate investigate VB cord-015306-us58wwmp 2202 69 the the DT cord-015306-us58wwmp 2202 70 mechanism mechanism NN cord-015306-us58wwmp 2202 71 of of IN cord-015306-us58wwmp 2202 72 SCF SCF NNP cord-015306-us58wwmp 2202 73 and and CC cord-015306-us58wwmp 2202 74 G G NNP cord-015306-us58wwmp 2202 75 - - HYPH cord-015306-us58wwmp 2202 76 CSF CSF NNP cord-015306-us58wwmp 2202 77 on on IN cord-015306-us58wwmp 2202 78 the the DT cord-015306-us58wwmp 2202 79 treatment treatment NN cord-015306-us58wwmp 2202 80 of of IN cord-015306-us58wwmp 2202 81 ischemia ischemia NN cord-015306-us58wwmp 2202 82 / / SYM cord-015306-us58wwmp 2202 83 reperfusion reperfusion NN cord-015306-us58wwmp 2202 84 - - HYPH cord-015306-us58wwmp 2202 85 induced induce VBN cord-015306-us58wwmp 2202 86 renal renal JJ cord-015306-us58wwmp 2202 87 injury injury NN cord-015306-us58wwmp 2202 88 . . . cord-015306-us58wwmp 2203 1 Methods method NNS cord-015306-us58wwmp 2203 2 : : : cord-015306-us58wwmp 2203 3 160 160 CD cord-015306-us58wwmp 2203 4 male male JJ cord-015306-us58wwmp 2203 5 Sprague Sprague NNP cord-015306-us58wwmp 2203 6 - - HYPH cord-015306-us58wwmp 2203 7 Dawley Dawley NNP cord-015306-us58wwmp 2203 8 rats rat NNS cord-015306-us58wwmp 2203 9 that that WDT cord-015306-us58wwmp 2203 10 are be VBP cord-015306-us58wwmp 2203 11 8 8 CD cord-015306-us58wwmp 2203 12 - - SYM cord-015306-us58wwmp 2203 13 10 10 CD cord-015306-us58wwmp 2203 14 weeks week NNS cord-015306-us58wwmp 2203 15 old old JJ cord-015306-us58wwmp 2203 16 were be VBD cord-015306-us58wwmp 2203 17 randomly randomly RB cord-015306-us58wwmp 2203 18 allocated allocate VBN cord-015306-us58wwmp 2203 19 into into IN cord-015306-us58wwmp 2203 20 4 4 CD cord-015306-us58wwmp 2203 21 groups group NNS cord-015306-us58wwmp 2203 22 ( ( -LRB- cord-015306-us58wwmp 2203 23 n n NN cord-015306-us58wwmp 2203 24 = = SYM cord-015306-us58wwmp 2203 25 40 40 CD cord-015306-us58wwmp 2203 26 ineach ineach JJ cord-015306-us58wwmp 2203 27 group group NN cord-015306-us58wwmp 2203 28 ) ) -RRB- cord-015306-us58wwmp 2203 29 : : : cord-015306-us58wwmp 2203 30 control control NNP cord-015306-us58wwmp 2203 31 group group NN cord-015306-us58wwmp 2203 32 ( ( -LRB- cord-015306-us58wwmp 2203 33 group group NN cord-015306-us58wwmp 2203 34 A A NNP cord-015306-us58wwmp 2203 35 ) ) -RRB- cord-015306-us58wwmp 2203 36 , , , cord-015306-us58wwmp 2203 37 ischemic ischemic JJ cord-015306-us58wwmp 2203 38 - - HYPH cord-015306-us58wwmp 2203 39 reperfusion reperfusion NN cord-015306-us58wwmp 2203 40 group group NN cord-015306-us58wwmp 2203 41 ( ( -LRB- cord-015306-us58wwmp 2203 42 group group NN cord-015306-us58wwmp 2203 43 B B NNP cord-015306-us58wwmp 2203 44 ) ) -RRB- cord-015306-us58wwmp 2203 45 , , , cord-015306-us58wwmp 2203 46 SCF SCF NNP cord-015306-us58wwmp 2203 47 + + CC cord-015306-us58wwmp 2203 48 G G NNP cord-015306-us58wwmp 2203 49 - - HYPH cord-015306-us58wwmp 2203 50 CSF csf NN cord-015306-us58wwmp 2203 51 + + CC cord-015306-us58wwmp 2203 52 ischemic ischemic JJ cord-015306-us58wwmp 2203 53 - - HYPH cord-015306-us58wwmp 2203 54 reperfusion reperfusion NN cord-015306-us58wwmp 2203 55 group group NN cord-015306-us58wwmp 2203 56 ( ( -LRB- cord-015306-us58wwmp 2203 57 group group NN cord-015306-us58wwmp 2203 58 C C NNP cord-015306-us58wwmp 2203 59 ) ) -RRB- cord-015306-us58wwmp 2203 60 and and CC cord-015306-us58wwmp 2203 61 SCF SCF NNP cord-015306-us58wwmp 2203 62 + + CC cord-015306-us58wwmp 2203 63 G G NNP cord-015306-us58wwmp 2203 64 - - HYPH cord-015306-us58wwmp 2203 65 CSF CSF NNP cord-015306-us58wwmp 2203 66 + + CC cord-015306-us58wwmp 2203 67 control control NN cord-015306-us58wwmp 2203 68 group group NN cord-015306-us58wwmp 2203 69 ( ( -LRB- cord-015306-us58wwmp 2203 70 group group NN cord-015306-us58wwmp 2203 71 D D NNP cord-015306-us58wwmp 2203 72 ) ) -RRB- cord-015306-us58wwmp 2203 73 . . . cord-015306-us58wwmp 2204 1 Detection detection NN cord-015306-us58wwmp 2204 2 index index NN cord-015306-us58wwmp 2204 3 : : : cord-015306-us58wwmp 2205 1 HIF-1α HIF-1α NNP cord-015306-us58wwmp 2205 2 was be VBD cord-015306-us58wwmp 2205 3 measured measure VBN cord-015306-us58wwmp 2205 4 by by IN cord-015306-us58wwmp 2205 5 immunohistochemistry immunohistochemistry NN cord-015306-us58wwmp 2205 6 technique technique NN cord-015306-us58wwmp 2205 7 , , , cord-015306-us58wwmp 2205 8 the the DT cord-015306-us58wwmp 2205 9 expression expression NN cord-015306-us58wwmp 2205 10 of of IN cord-015306-us58wwmp 2205 11 EGF EGF NNP cord-015306-us58wwmp 2205 12 and and CC cord-015306-us58wwmp 2205 13 CD34 CD34 NNP cord-015306-us58wwmp 2205 14 + + CC cord-015306-us58wwmp 2205 15 cells cell NNS cord-015306-us58wwmp 2205 16 in in IN cord-015306-us58wwmp 2205 17 kidney kidney NN cord-015306-us58wwmp 2205 18 was be VBD cord-015306-us58wwmp 2205 19 measured measure VBN cord-015306-us58wwmp 2205 20 by by IN cord-015306-us58wwmp 2205 21 strept strept NNP cord-015306-us58wwmp 2205 22 avidin avidin NNP cord-015306-us58wwmp 2205 23 - - HYPH cord-015306-us58wwmp 2205 24 biotin biotin NN cord-015306-us58wwmp 2205 25 - - HYPH cord-015306-us58wwmp 2205 26 peroxidase(SABC peroxidase(sabc NN cord-015306-us58wwmp 2205 27 ) ) -RRB- cord-015306-us58wwmp 2205 28 and and CC cord-015306-us58wwmp 2205 29 EGF EGF NNP cord-015306-us58wwmp 2205 30 mRNA mrna NN cord-015306-us58wwmp 2205 31 by by IN cord-015306-us58wwmp 2205 32 RT RT NNP cord-015306-us58wwmp 2205 33 - - HYPH cord-015306-us58wwmp 2205 34 PCR PCR NNP cord-015306-us58wwmp 2205 35 . . . cord-015306-us58wwmp 2206 1 Results result NNS cord-015306-us58wwmp 2206 2 : : : cord-015306-us58wwmp 2206 3 ( ( -LRB- cord-015306-us58wwmp 2206 4 1 1 LS cord-015306-us58wwmp 2206 5 ) ) -RRB- cord-015306-us58wwmp 2207 1 At at IN cord-015306-us58wwmp 2207 2 5 5 CD cord-015306-us58wwmp 2207 3 days day NNS cord-015306-us58wwmp 2207 4 postoperative postoperative JJ cord-015306-us58wwmp 2207 5 , , , cord-015306-us58wwmp 2207 6 the the DT cord-015306-us58wwmp 2207 7 CD34 CD34 NNP cord-015306-us58wwmp 2207 8 + + CC cord-015306-us58wwmp 2207 9 cells cell NNS cord-015306-us58wwmp 2207 10 of of IN cord-015306-us58wwmp 2207 11 group group NN cord-015306-us58wwmp 2207 12 B B NNP cord-015306-us58wwmp 2207 13 and and CC cord-015306-us58wwmp 2207 14 C C NNP cord-015306-us58wwmp 2207 15 was be VBD cord-015306-us58wwmp 2207 16 conspicuous conspicuous JJ cord-015306-us58wwmp 2207 17 higher high JJR cord-015306-us58wwmp 2207 18 than than IN cord-015306-us58wwmp 2207 19 group group NN cord-015306-us58wwmp 2207 20 A A NNP cord-015306-us58wwmp 2207 21 and and CC cord-015306-us58wwmp 2207 22 D(P<0.05 D(P<0.05 NNP cord-015306-us58wwmp 2207 23 ) ) -RRB- cord-015306-us58wwmp 2207 24 , , , cord-015306-us58wwmp 2207 25 group group NN cord-015306-us58wwmp 2207 26 C C NNP cord-015306-us58wwmp 2207 27 was be VBD cord-015306-us58wwmp 2207 28 higher high JJR cord-015306-us58wwmp 2207 29 than than IN cord-015306-us58wwmp 2207 30 group group NN cord-015306-us58wwmp 2207 31 B(P<0.05 B(P<0.05 NNP cord-015306-us58wwmp 2207 32 ) ) -RRB- cord-015306-us58wwmp 2207 33 . . . cord-015306-us58wwmp 2208 1 They -PRON- PRP cord-015306-us58wwmp 2208 2 gradually gradually RB cord-015306-us58wwmp 2208 3 descended descend VBD cord-015306-us58wwmp 2208 4 from from IN cord-015306-us58wwmp 2208 5 5 5 CD cord-015306-us58wwmp 2208 6 days day NNS cord-015306-us58wwmp 2208 7 with with IN cord-015306-us58wwmp 2208 8 the the DT cord-015306-us58wwmp 2208 9 time time NN cord-015306-us58wwmp 2208 10 prolonged prolong VBN cord-015306-us58wwmp 2208 11 . . . cord-015306-us58wwmp 2209 1 ( ( -LRB- cord-015306-us58wwmp 2209 2 2)At 2)at CD cord-015306-us58wwmp 2209 3 5 5 CD cord-015306-us58wwmp 2209 4 days day NNS cord-015306-us58wwmp 2209 5 postoperative postoperative JJ cord-015306-us58wwmp 2209 6 , , , cord-015306-us58wwmp 2209 7 there there EX cord-015306-us58wwmp 2209 8 was be VBD cord-015306-us58wwmp 2209 9 significant significant JJ cord-015306-us58wwmp 2209 10 difference difference NN cord-015306-us58wwmp 2209 11 of of IN cord-015306-us58wwmp 2209 12 the the DT cord-015306-us58wwmp 2209 13 expression expression NN cord-015306-us58wwmp 2209 14 of of IN cord-015306-us58wwmp 2209 15 HIF-1α HIF-1α NNP cord-015306-us58wwmp 2209 16 between between IN cord-015306-us58wwmp 2209 17 group group NN cord-015306-us58wwmp 2209 18 A a NN cord-015306-us58wwmp 2209 19 and and CC cord-015306-us58wwmp 2209 20 D D NNP cord-015306-us58wwmp 2209 21 ( ( -LRB- cord-015306-us58wwmp 2209 22 P<0.05 P<0.05 NNP cord-015306-us58wwmp 2209 23 ) ) -RRB- cord-015306-us58wwmp 2209 24 . . . cord-015306-us58wwmp 2210 1 The the DT cord-015306-us58wwmp 2210 2 expression expression NN cord-015306-us58wwmp 2210 3 of of IN cord-015306-us58wwmp 2210 4 HIF-1α HIF-1α NNP cord-015306-us58wwmp 2210 5 of of IN cord-015306-us58wwmp 2210 6 group group NN cord-015306-us58wwmp 2210 7 B B NNP cord-015306-us58wwmp 2210 8 and and CC cord-015306-us58wwmp 2210 9 C C NNP cord-015306-us58wwmp 2210 10 showed show VBD cord-015306-us58wwmp 2210 11 higher high JJR cord-015306-us58wwmp 2210 12 positive positive JJ cord-015306-us58wwmp 2210 13 reaction reaction NN cord-015306-us58wwmp 2210 14 at at IN cord-015306-us58wwmp 2210 15 5 5 CD cord-015306-us58wwmp 2210 16 days day NNS cord-015306-us58wwmp 2210 17 postoperative postoperative JJ cord-015306-us58wwmp 2210 18 then then RB cord-015306-us58wwmp 2210 19 decent decent JJ cord-015306-us58wwmp 2210 20 to to IN cord-015306-us58wwmp 2210 21 normal normal JJ cord-015306-us58wwmp 2210 22 . . . cord-015306-us58wwmp 2211 1 At at IN cord-015306-us58wwmp 2211 2 each each DT cord-015306-us58wwmp 2211 3 time time NN cord-015306-us58wwmp 2211 4 the the DT cord-015306-us58wwmp 2211 5 expression expression NN cord-015306-us58wwmp 2211 6 of of IN cord-015306-us58wwmp 2211 7 HIF-1α HIF-1α NNP cord-015306-us58wwmp 2211 8 of of IN cord-015306-us58wwmp 2211 9 group group NN cord-015306-us58wwmp 2211 10 C C NNP cord-015306-us58wwmp 2211 11 was be VBD cord-015306-us58wwmp 2211 12 significant significant JJ cord-015306-us58wwmp 2211 13 higher high JJR cord-015306-us58wwmp 2211 14 than than IN cord-015306-us58wwmp 2211 15 other other JJ cord-015306-us58wwmp 2211 16 groups group NNS cord-015306-us58wwmp 2211 17 ( ( -LRB- cord-015306-us58wwmp 2211 18 P<0.05 P<0.05 NNS cord-015306-us58wwmp 2211 19 ) ) -RRB- cord-015306-us58wwmp 2211 20 . . . cord-015306-us58wwmp 2212 1 ( ( -LRB- cord-015306-us58wwmp 2212 2 3)The 3)the CD cord-015306-us58wwmp 2212 3 EGF EGF NNP cord-015306-us58wwmp 2212 4 expression expression NN cord-015306-us58wwmp 2212 5 of of IN cord-015306-us58wwmp 2212 6 group group NN cord-015306-us58wwmp 2212 7 B B NNP cord-015306-us58wwmp 2212 8 and and CC cord-015306-us58wwmp 2212 9 C C NNP cord-015306-us58wwmp 2212 10 showed show VBD cord-015306-us58wwmp 2212 11 higher high JJR cord-015306-us58wwmp 2212 12 positive positive JJ cord-015306-us58wwmp 2212 13 reaction reaction NN cord-015306-us58wwmp 2212 14 at at IN cord-015306-us58wwmp 2212 15 5 5 CD cord-015306-us58wwmp 2212 16 days day NNS cord-015306-us58wwmp 2212 17 postoperative postoperative JJ cord-015306-us58wwmp 2212 18 and and CC cord-015306-us58wwmp 2212 19 decent decent JJ cord-015306-us58wwmp 2212 20 to to IN cord-015306-us58wwmp 2212 21 normal normal JJ cord-015306-us58wwmp 2212 22 with with IN cord-015306-us58wwmp 2212 23 the the DT cord-015306-us58wwmp 2212 24 time time NN cord-015306-us58wwmp 2212 25 prolonged prolong VBN cord-015306-us58wwmp 2212 26 , , , cord-015306-us58wwmp 2212 27 group group NN cord-015306-us58wwmp 2212 28 B b NN cord-015306-us58wwmp 2212 29 peaks peak NNS cord-015306-us58wwmp 2212 30 at at IN cord-015306-us58wwmp 2212 31 17 17 CD cord-015306-us58wwmp 2212 32 days day NNS cord-015306-us58wwmp 2212 33 and and CC cord-015306-us58wwmp 2212 34 higher high JJR cord-015306-us58wwmp 2212 35 than than IN cord-015306-us58wwmp 2212 36 group group NN cord-015306-us58wwmp 2212 37 A A NNP cord-015306-us58wwmp 2212 38 , , , cord-015306-us58wwmp 2212 39 group group NN cord-015306-us58wwmp 2212 40 C c NN cord-015306-us58wwmp 2212 41 peaks peak NNS cord-015306-us58wwmp 2212 42 at at IN cord-015306-us58wwmp 2212 43 10 10 CD cord-015306-us58wwmp 2212 44 days day NNS cord-015306-us58wwmp 2212 45 , , , cord-015306-us58wwmp 2212 46 and and CC cord-015306-us58wwmp 2212 47 it -PRON- PRP cord-015306-us58wwmp 2212 48 is be VBZ cord-015306-us58wwmp 2212 49 the the DT cord-015306-us58wwmp 2212 50 highest high JJS cord-015306-us58wwmp 2212 51 ( ( -LRB- cord-015306-us58wwmp 2212 52 P<0.05 p<0.05 JJ cord-015306-us58wwmp 2212 53 Results result NNS cord-015306-us58wwmp 2212 54 : : : cord-015306-us58wwmp 2213 1 In in IN cord-015306-us58wwmp 2213 2 contrast contrast NN cord-015306-us58wwmp 2213 3 to to IN cord-015306-us58wwmp 2213 4 model model NN cord-015306-us58wwmp 2213 5 group group NN cord-015306-us58wwmp 2213 6 , , , cord-015306-us58wwmp 2213 7 ATN ATN NNP cord-015306-us58wwmp 2213 8 treated treat VBD cord-015306-us58wwmp 2213 9 with with IN cord-015306-us58wwmp 2213 10 ADSCs adsc NNS cord-015306-us58wwmp 2213 11 displayed display VBN cord-015306-us58wwmp 2213 12 : : : cord-015306-us58wwmp 2213 13 cells cell NNS cord-015306-us58wwmp 2213 14 expressing express VBG cord-015306-us58wwmp 2213 15 green green JJ cord-015306-us58wwmp 2213 16 fluorescent fluorescent NN cord-015306-us58wwmp 2213 17 protein protein NN cord-015306-us58wwmp 2213 18 were be VBD cord-015306-us58wwmp 2213 19 dectected dectecte VBN cord-015306-us58wwmp 2213 20 in in IN cord-015306-us58wwmp 2213 21 injured injured JJ cord-015306-us58wwmp 2213 22 tubule tubule NN cord-015306-us58wwmp 2213 23 in in IN cord-015306-us58wwmp 2213 24 kidney kidney NN cord-015306-us58wwmp 2213 25 . . . cord-015306-us58wwmp 2214 1 treatment treatment NN cord-015306-us58wwmp 2214 2 group group NN cord-015306-us58wwmp 2214 3 were be VBD cord-015306-us58wwmp 2214 4 significantly significantly RB cord-015306-us58wwmp 2214 5 higher high JJR cord-015306-us58wwmp 2214 6 than than IN cord-015306-us58wwmp 2214 7 model model NN cord-015306-us58wwmp 2214 8 group group NN cord-015306-us58wwmp 2214 9 , , , cord-015306-us58wwmp 2214 10 P<0.05 p<0.05 JJ cord-015306-us58wwmp 2214 11 ; ; : cord-015306-us58wwmp 2214 12 Renal renal JJ cord-015306-us58wwmp 2214 13 damage damage NN cord-015306-us58wwmp 2214 14 is be VBZ cord-015306-us58wwmp 2214 15 lighter light JJR cord-015306-us58wwmp 2214 16 ; ; : cord-015306-us58wwmp 2214 17 kidney kidney NN cord-015306-us58wwmp 2214 18 damages damage NNS cord-015306-us58wwmp 2214 19 were be VBD cord-015306-us58wwmp 2214 20 relative relative JJ cord-015306-us58wwmp 2214 21 gently gently RB cord-015306-us58wwmp 2214 22 and and CC cord-015306-us58wwmp 2214 23 histopathologic histopathologic JJ cord-015306-us58wwmp 2214 24 lesion lesion NN cord-015306-us58wwmp 2214 25 scores score NNS cord-015306-us58wwmp 2214 26 was be VBD cord-015306-us58wwmp 2214 27 relative relative JJ cord-015306-us58wwmp 2214 28 lower low JJR cord-015306-us58wwmp 2214 29 ; ; : cord-015306-us58wwmp 2214 30 while while IN cord-015306-us58wwmp 2214 31 Ki-67 Ki-67 NNP cord-015306-us58wwmp 2214 32 positivece positivece NN cord-015306-us58wwmp 2214 33 cells cell NNS cord-015306-us58wwmp 2214 34 in in IN cord-015306-us58wwmp 2214 35 treatment treatment NN cord-015306-us58wwmp 2214 36 group group NN cord-015306-us58wwmp 2214 37 were be VBD cord-015306-us58wwmp 2214 38 more more JJR cord-015306-us58wwmp 2214 39 than than IN cord-015306-us58wwmp 2214 40 those those DT cord-015306-us58wwmp 2214 41 in in IN cord-015306-us58wwmp 2214 42 model model NN cord-015306-us58wwmp 2214 43 group group NN cord-015306-us58wwmp 2214 44 ( ( -LRB- cord-015306-us58wwmp 2214 45 P<0.05 P<0.05 NNP cord-015306-us58wwmp 2214 46 ) ) -RRB- cord-015306-us58wwmp 2214 47 ; ; : cord-015306-us58wwmp 2214 48 The the DT cord-015306-us58wwmp 2214 49 expression expression NN cord-015306-us58wwmp 2214 50 of of IN cord-015306-us58wwmp 2214 51 Bax Bax NNP cord-015306-us58wwmp 2214 52 , , , cord-015306-us58wwmp 2214 53 Bcl-2 Bcl-2 NNP cord-015306-us58wwmp 2214 54 and and CC cord-015306-us58wwmp 2214 55 cell cell NN cord-015306-us58wwmp 2214 56 apoptotic apoptotic JJ cord-015306-us58wwmp 2214 57 index(AI index(AI NNS cord-015306-us58wwmp 2214 58 ) ) -RRB- cord-015306-us58wwmp 2214 59 in in IN cord-015306-us58wwmp 2214 60 treatment treatment NN cord-015306-us58wwmp 2214 61 group group NN cord-015306-us58wwmp 2214 62 was be VBD cord-015306-us58wwmp 2214 63 lower low JJR cord-015306-us58wwmp 2214 64 than than IN cord-015306-us58wwmp 2214 65 those those DT cord-015306-us58wwmp 2214 66 in in IN cord-015306-us58wwmp 2214 67 model model NN cord-015306-us58wwmp 2214 68 group group NN cord-015306-us58wwmp 2214 69 , , , cord-015306-us58wwmp 2214 70 P<0.05 P<0.05 NNP cord-015306-us58wwmp 2214 71 , , , cord-015306-us58wwmp 2214 72 but but CC cord-015306-us58wwmp 2215 1 Bax Bax NNP cord-015306-us58wwmp 2215 2 / / SYM cord-015306-us58wwmp 2215 3 Bcl-2 Bcl-2 NNP cord-015306-us58wwmp 2215 4 ratio ratio NN cord-015306-us58wwmp 2215 5 was be VBD cord-015306-us58wwmp 2215 6 higher high JJR cord-015306-us58wwmp 2215 7 than than IN cord-015306-us58wwmp 2215 8 those those DT cord-015306-us58wwmp 2215 9 in in IN cord-015306-us58wwmp 2215 10 model model NN cord-015306-us58wwmp 2215 11 group group NN cord-015306-us58wwmp 2215 12 . . . cord-015306-us58wwmp 2216 1 Conclusion conclusion NN cord-015306-us58wwmp 2216 2 : : : cord-015306-us58wwmp 2217 1 Allogenic allogenic JJ cord-015306-us58wwmp 2217 2 ADSCs adscs JJ cord-015306-us58wwmp 2217 3 transplantation transplantation NN cord-015306-us58wwmp 2217 4 can can MD cord-015306-us58wwmp 2217 5 accelerate accelerate VB cord-015306-us58wwmp 2217 6 proliferation proliferation NN cord-015306-us58wwmp 2217 7 of of IN cord-015306-us58wwmp 2217 8 renal renal JJ cord-015306-us58wwmp 2217 9 tubular tubular JJ cord-015306-us58wwmp 2217 10 epithelial epithelial JJ cord-015306-us58wwmp 2217 11 cell cell NN cord-015306-us58wwmp 2217 12 and and CC cord-015306-us58wwmp 2217 13 suppress suppress VB cord-015306-us58wwmp 2217 14 apeptosis apeptosis NN cord-015306-us58wwmp 2217 15 injury injury NN cord-015306-us58wwmp 2217 16 through through IN cord-015306-us58wwmp 2217 17 up up IN cord-015306-us58wwmp 2217 18 - - HYPH cord-015306-us58wwmp 2217 19 regulating regulate VBG cord-015306-us58wwmp 2217 20 the the DT cord-015306-us58wwmp 2217 21 ratio ratio NN cord-015306-us58wwmp 2217 22 of of IN cord-015306-us58wwmp 2217 23 Bcl-2/ Bcl-2/ NNP cord-015306-us58wwmp 2217 24 Bax Bax NNP cord-015306-us58wwmp 2217 25 and and CC cord-015306-us58wwmp 2217 26 down down RB cord-015306-us58wwmp 2217 27 - - HYPH cord-015306-us58wwmp 2217 28 regulating regulate VBG cord-015306-us58wwmp 2217 29 the the DT cord-015306-us58wwmp 2217 30 expression expression NN cord-015306-us58wwmp 2217 31 of of IN cord-015306-us58wwmp 2217 32 Bax Bax NNP cord-015306-us58wwmp 2217 33 protein protein NN cord-015306-us58wwmp 2217 34 in in IN cord-015306-us58wwmp 2217 35 acute acute JJ cord-015306-us58wwmp 2217 36 kidney kidney NN cord-015306-us58wwmp 2217 37 injury injury NN cord-015306-us58wwmp 2217 38 . . . cord-015306-us58wwmp 2218 1 Objective objective NN cord-015306-us58wwmp 2218 2 : : : cord-015306-us58wwmp 2218 3 Previously previously RB cord-015306-us58wwmp 2218 4 we -PRON- PRP cord-015306-us58wwmp 2218 5 showed show VBD cord-015306-us58wwmp 2218 6 that that IN cord-015306-us58wwmp 2218 7 pretreatment pretreatment NN cord-015306-us58wwmp 2218 8 with with IN cord-015306-us58wwmp 2218 9 the the DT cord-015306-us58wwmp 2218 10 antidepressant antidepressant NN cord-015306-us58wwmp 2218 11 fluvoxamine fluvoxamine NN cord-015306-us58wwmp 2218 12 ( ( -LRB- cord-015306-us58wwmp 2218 13 FLU FLU NNP cord-015306-us58wwmp 2218 14 ) ) -RRB- cord-015306-us58wwmp 2218 15 improves improve VBZ cord-015306-us58wwmp 2218 16 postischemic postischemic JJ cord-015306-us58wwmp 2218 17 survival survival NN cord-015306-us58wwmp 2218 18 and and CC cord-015306-us58wwmp 2218 19 ameliorates ameliorate VBZ cord-015306-us58wwmp 2218 20 functional functional JJ cord-015306-us58wwmp 2218 21 and and CC cord-015306-us58wwmp 2218 22 structural structural JJ cord-015306-us58wwmp 2218 23 kidney kidney NN cord-015306-us58wwmp 2218 24 damage damage NN cord-015306-us58wwmp 2218 25 after after IN cord-015306-us58wwmp 2218 26 renal renal JJ cord-015306-us58wwmp 2218 27 ischemia ischemia NN cord-015306-us58wwmp 2218 28 / / SYM cord-015306-us58wwmp 2218 29 reperfusion reperfusion NN cord-015306-us58wwmp 2218 30 ( ( -LRB- cord-015306-us58wwmp 2218 31 IR IR NNP cord-015306-us58wwmp 2218 32 ) ) -RRB- cord-015306-us58wwmp 2218 33 . . . cord-015306-us58wwmp 2219 1 In in IN cord-015306-us58wwmp 2219 2 heart heart NN cord-015306-us58wwmp 2219 3 IR IR NNP cord-015306-us58wwmp 2219 4 injury injury NN cord-015306-us58wwmp 2219 5 FLU FLU NNP cord-015306-us58wwmp 2219 6 is be VBZ cord-015306-us58wwmp 2219 7 protective protective JJ cord-015306-us58wwmp 2219 8 through through IN cord-015306-us58wwmp 2219 9 activating activate VBG cord-015306-us58wwmp 2219 10 the the DT cord-015306-us58wwmp 2219 11 Sigma-1 Sigma-1 NNP cord-015306-us58wwmp 2219 12 receptor receptor NN cord-015306-us58wwmp 2219 13 ( ( -LRB- cord-015306-us58wwmp 2219 14 S1R s1r NN cord-015306-us58wwmp 2219 15 ) ) -RRB- cord-015306-us58wwmp 2219 16 -nitric -nitric JJ cord-015306-us58wwmp 2219 17 - - HYPH cord-015306-us58wwmp 2219 18 oxide oxide NN cord-015306-us58wwmp 2219 19 synthase synthase NN cord-015306-us58wwmp 2219 20 ( ( -LRB- cord-015306-us58wwmp 2219 21 NOS NOS NNP cord-015306-us58wwmp 2219 22 ) ) -RRB- cord-015306-us58wwmp 2219 23 system system NN cord-015306-us58wwmp 2219 24 . . . cord-015306-us58wwmp 2220 1 Here here RB cord-015306-us58wwmp 2220 2 we -PRON- PRP cord-015306-us58wwmp 2220 3 studied study VBD cord-015306-us58wwmp 2220 4 the the DT cord-015306-us58wwmp 2220 5 intrarenal intrarenal JJ cord-015306-us58wwmp 2220 6 vasoregulatory vasoregulatory NNP cord-015306-us58wwmp 2220 7 effect effect NN cord-015306-us58wwmp 2220 8 of of IN cord-015306-us58wwmp 2220 9 FLU FLU NNP cord-015306-us58wwmp 2220 10 and and CC cord-015306-us58wwmp 2220 11 analyzed analyze VBD cord-015306-us58wwmp 2220 12 the the DT cord-015306-us58wwmp 2220 13 renal renal JJ cord-015306-us58wwmp 2220 14 S1R s1r NN cord-015306-us58wwmp 2220 15 - - HYPH cord-015306-us58wwmp 2220 16 NOS NOS NNP cord-015306-us58wwmp 2220 17 cascade cascade NN cord-015306-us58wwmp 2220 18 . . . cord-015306-us58wwmp 2221 1 Methods method NNS cord-015306-us58wwmp 2221 2 : : : cord-015306-us58wwmp 2222 1 Male male JJ cord-015306-us58wwmp 2222 2 Wistar Wistar NNP cord-015306-us58wwmp 2222 3 rats rat NNS cord-015306-us58wwmp 2222 4 were be VBD cord-015306-us58wwmp 2222 5 were be VBD cord-015306-us58wwmp 2222 6 treated treat VBN cord-015306-us58wwmp 2222 7 i.p i.p NNP cord-015306-us58wwmp 2222 8 . . . cord-015306-us58wwmp 2223 1 either either CC cord-015306-us58wwmp 2223 2 with with IN cord-015306-us58wwmp 2224 1 ( ( -LRB- cord-015306-us58wwmp 2224 2 1 1 LS cord-015306-us58wwmp 2224 3 ) ) -RRB- cord-015306-us58wwmp 2224 4 vehiculum vehiculum NN cord-015306-us58wwmp 2224 5 ( ( -LRB- cord-015306-us58wwmp 2224 6 VEH VEH NNP cord-015306-us58wwmp 2224 7 ) ) -RRB- cord-015306-us58wwmp 2224 8 ; ; : cord-015306-us58wwmp 2224 9 ( ( -LRB- cord-015306-us58wwmp 2224 10 2 2 LS cord-015306-us58wwmp 2224 11 ) ) -RRB- cord-015306-us58wwmp 2224 12 FLU flu NN cord-015306-us58wwmp 2224 13 ( ( -LRB- cord-015306-us58wwmp 2224 14 20 20 CD cord-015306-us58wwmp 2224 15 mg mg NNP cord-015306-us58wwmp 2224 16 / / SYM cord-015306-us58wwmp 2224 17 bwkg bwkg NNP cord-015306-us58wwmp 2224 18 ; ; : cord-015306-us58wwmp 2224 19 FLU FLU NNP cord-015306-us58wwmp 2224 20 ) ) -RRB- cord-015306-us58wwmp 2224 21 ; ; : cord-015306-us58wwmp 2225 1 ( ( -LRB- cord-015306-us58wwmp 2225 2 3 3 LS cord-015306-us58wwmp 2225 3 ) ) -RRB- cord-015306-us58wwmp 2225 4 FLU+ flu+ JJ cord-015306-us58wwmp 2225 5 S1R s1r NN cord-015306-us58wwmp 2225 6 antagonist antagonist NN cord-015306-us58wwmp 2225 7 NE-100 ne-100 NN cord-015306-us58wwmp 2226 1 ( ( -LRB- cord-015306-us58wwmp 2226 2 1mg 1mg NNP cord-015306-us58wwmp 2226 3 / / SYM cord-015306-us58wwmp 2226 4 bwkg bwkg NNP cord-015306-us58wwmp 2226 5 ; ; : cord-015306-us58wwmp 2226 6 FN FN NNP cord-015306-us58wwmp 2226 7 ) ) -RRB- cord-015306-us58wwmp 2226 8 ; ; : cord-015306-us58wwmp 2227 1 ( ( -LRB- cord-015306-us58wwmp 2227 2 4 4 LS cord-015306-us58wwmp 2227 3 ) ) -RRB- cord-015306-us58wwmp 2227 4 FLU+ flu+ JJ cord-015306-us58wwmp 2227 5 non non JJ cord-015306-us58wwmp 2227 6 - - JJ cord-015306-us58wwmp 2227 7 selective selective JJ cord-015306-us58wwmp 2227 8 NOS NOS NNP cord-015306-us58wwmp 2227 9 blocker blocker NN cord-015306-us58wwmp 2227 10 L L NNP cord-015306-us58wwmp 2227 11 - - HYPH cord-015306-us58wwmp 2227 12 NAME NAME NNP cord-015306-us58wwmp 2227 13 ( ( -LRB- cord-015306-us58wwmp 2227 14 10mg 10mg NNP cord-015306-us58wwmp 2227 15 / / SYM cord-015306-us58wwmp 2227 16 bwkg bwkg NNP cord-015306-us58wwmp 2227 17 ) ) -RRB- cord-015306-us58wwmp 2227 18 ; ; : cord-015306-us58wwmp 2227 19 ( ( -LRB- cord-015306-us58wwmp 2227 20 5 5 LS cord-015306-us58wwmp 2227 21 ) ) -RRB- cord-015306-us58wwmp 2227 22 FLU flu NN cord-015306-us58wwmp 2227 23 + + CC cord-015306-us58wwmp 2227 24 selective selective JJ cord-015306-us58wwmp 2227 25 endothelial endothelial NN cord-015306-us58wwmp 2227 26 ( ( -LRB- cord-015306-us58wwmp 2227 27 e e NN cord-015306-us58wwmp 2227 28 ) ) -RRB- cord-015306-us58wwmp 2227 29 NOS NOS NNP cord-015306-us58wwmp 2227 30 blocker blocker NN cord-015306-us58wwmp 2227 31 L L NNP cord-015306-us58wwmp 2227 32 - - HYPH cord-015306-us58wwmp 2227 33 NIO NIO NNP cord-015306-us58wwmp 2227 34 ( ( -LRB- cord-015306-us58wwmp 2227 35 20mg 20mg NNP cord-015306-us58wwmp 2227 36 / / SYM cord-015306-us58wwmp 2227 37 bwkg bwkg NNP cord-015306-us58wwmp 2227 38 ) ) -RRB- cord-015306-us58wwmp 2227 39 ; ; : cord-015306-us58wwmp 2227 40 ( ( -LRB- cord-015306-us58wwmp 2227 41 6 6 LS cord-015306-us58wwmp 2227 42 ) ) -RRB- cord-015306-us58wwmp 2227 43 FLU flu NN cord-015306-us58wwmp 2227 44 and and CC cord-015306-us58wwmp 2227 45 selective selective JJ cord-015306-us58wwmp 2227 46 neuronal neuronal JJ cord-015306-us58wwmp 2227 47 ( ( -LRB- cord-015306-us58wwmp 2227 48 n n NN cord-015306-us58wwmp 2227 49 ) ) -RRB- cord-015306-us58wwmp 2227 50 NOS NOS NNP cord-015306-us58wwmp 2227 51 blocker blocker NN cord-015306-us58wwmp 2228 1 7-NI 7-ni CD cord-015306-us58wwmp 2228 2 ( ( -LRB- cord-015306-us58wwmp 2228 3 25mg 25mg NNP cord-015306-us58wwmp 2228 4 / / SYM cord-015306-us58wwmp 2228 5 bwkg bwkg NNP cord-015306-us58wwmp 2228 6 ) ) -RRB- cord-015306-us58wwmp 2228 7 . . . cord-015306-us58wwmp 2229 1 30 30 CD cord-015306-us58wwmp 2229 2 minutes minute NNS cord-015306-us58wwmp 2229 3 later later RBR cord-015306-us58wwmp 2229 4 rats rat NNS cord-015306-us58wwmp 2229 5 were be VBD cord-015306-us58wwmp 2229 6 either either CC cord-015306-us58wwmp 2229 7 harvested harvest VBN cord-015306-us58wwmp 2229 8 or or CC cord-015306-us58wwmp 2229 9 subjected subject VBN cord-015306-us58wwmp 2229 10 to to IN cord-015306-us58wwmp 2229 11 50 50 CD cord-015306-us58wwmp 2229 12 minutes minute NNS cord-015306-us58wwmp 2229 13 of of IN cord-015306-us58wwmp 2229 14 ischemia ischemia NN cord-015306-us58wwmp 2229 15 followed follow VBN cord-015306-us58wwmp 2229 16 by by IN cord-015306-us58wwmp 2229 17 24 24 CD cord-015306-us58wwmp 2229 18 hours hour NNS cord-015306-us58wwmp 2229 19 of of IN cord-015306-us58wwmp 2229 20 reperfusion reperfusion NN cord-015306-us58wwmp 2229 21 . . . cord-015306-us58wwmp 2230 1 Sham Sham NNP cord-015306-us58wwmp 2230 2 - - HYPH cord-015306-us58wwmp 2230 3 operated operate VBN cord-015306-us58wwmp 2230 4 animals animal NNS cord-015306-us58wwmp 2230 5 served serve VBD cord-015306-us58wwmp 2230 6 as as IN cord-015306-us58wwmp 2230 7 controls control NNS cord-015306-us58wwmp 2230 8 ( ( -LRB- cord-015306-us58wwmp 2230 9 n=10 n=10 NNP cord-015306-us58wwmp 2230 10 / / SYM cord-015306-us58wwmp 2230 11 group group NN cord-015306-us58wwmp 2230 12 ) ) -RRB- cord-015306-us58wwmp 2230 13 . . . cord-015306-us58wwmp 2231 1 Renal renal JJ cord-015306-us58wwmp 2231 2 S1R s1r NN cord-015306-us58wwmp 2231 3 , , , cord-015306-us58wwmp 2231 4 Akt Akt NNP cord-015306-us58wwmp 2231 5 , , , cord-015306-us58wwmp 2231 6 eNOS enos JJ cord-015306-us58wwmp 2231 7 and and CC cord-015306-us58wwmp 2231 8 nNOS nnos JJ cord-015306-us58wwmp 2231 9 protein protein NN cord-015306-us58wwmp 2231 10 levels level NNS cord-015306-us58wwmp 2231 11 were be VBD cord-015306-us58wwmp 2231 12 measured measure VBN cord-015306-us58wwmp 2231 13 , , , cord-015306-us58wwmp 2231 14 the the DT cord-015306-us58wwmp 2231 15 alteration alteration NN cord-015306-us58wwmp 2231 16 of of IN cord-015306-us58wwmp 2231 17 renal renal JJ cord-015306-us58wwmp 2231 18 capillary capillary JJ cord-015306-us58wwmp 2231 19 diameters diameter NNS cord-015306-us58wwmp 2231 20 was be VBD cord-015306-us58wwmp 2231 21 determined determine VBN cord-015306-us58wwmp 2231 22 in in IN cord-015306-us58wwmp 2231 23 vivo vivo NN cord-015306-us58wwmp 2231 24 using use VBG cord-015306-us58wwmp 2231 25 muliphoton muliphoton NN cord-015306-us58wwmp 2231 26 microscopy microscopy NNP cord-015306-us58wwmp 2231 27 . . . cord-015306-us58wwmp 2232 1 Results result NNS cord-015306-us58wwmp 2233 1 : : : cord-015306-us58wwmp 2233 2 IR IR NNP cord-015306-us58wwmp 2233 3 induced induce VBD cord-015306-us58wwmp 2233 4 renal renal JJ cord-015306-us58wwmp 2233 5 vasoconstriction vasoconstriction NN cord-015306-us58wwmp 2233 6 , , , cord-015306-us58wwmp 2233 7 which which WDT cord-015306-us58wwmp 2233 8 was be VBD cord-015306-us58wwmp 2233 9 ameliorated ameliorate VBN cord-015306-us58wwmp 2233 10 by by IN cord-015306-us58wwmp 2233 11 FLU FLU NNP cord-015306-us58wwmp 2233 12 . . . cord-015306-us58wwmp 2234 1 This this DT cord-015306-us58wwmp 2234 2 increase increase NN cord-015306-us58wwmp 2234 3 was be VBD cord-015306-us58wwmp 2234 4 neutralized neutralize VBN cord-015306-us58wwmp 2234 5 by by IN cord-015306-us58wwmp 2234 6 all all DT cord-015306-us58wwmp 2234 7 NOS NOS NNP cord-015306-us58wwmp 2234 8 blockers blocker NNS cord-015306-us58wwmp 2234 9 , , , cord-015306-us58wwmp 2234 10 mostly mostly RB cord-015306-us58wwmp 2234 11 by by IN cord-015306-us58wwmp 2234 12 7-NI 7-ni CD cord-015306-us58wwmp 2234 13 . . . cord-015306-us58wwmp 2235 1 After after IN cord-015306-us58wwmp 2235 2 IR IR NNP cord-015306-us58wwmp 2235 3 all all DT cord-015306-us58wwmp 2235 4 measured measure VBN cord-015306-us58wwmp 2235 5 protein protein NN cord-015306-us58wwmp 2235 6 levels level NNS cord-015306-us58wwmp 2235 7 increased increase VBD cord-015306-us58wwmp 2235 8 . . . cord-015306-us58wwmp 2236 1 S1R s1r JJ cord-015306-us58wwmp 2236 2 expression expression NN cord-015306-us58wwmp 2236 3 was be VBD cord-015306-us58wwmp 2236 4 similar similar JJ cord-015306-us58wwmp 2236 5 in in IN cord-015306-us58wwmp 2236 6 all all DT cord-015306-us58wwmp 2236 7 treatment treatment NN cord-015306-us58wwmp 2236 8 groups group NNS cord-015306-us58wwmp 2236 9 . . . cord-015306-us58wwmp 2237 1 Akt Akt NNP cord-015306-us58wwmp 2237 2 and and CC cord-015306-us58wwmp 2237 3 eNOS enos JJ cord-015306-us58wwmp 2237 4 levels level NNS cord-015306-us58wwmp 2237 5 were be VBD cord-015306-us58wwmp 2237 6 lower low JJR cord-015306-us58wwmp 2237 7 , , , cord-015306-us58wwmp 2237 8 while while IN cord-015306-us58wwmp 2237 9 nNOS nnos JJ cord-015306-us58wwmp 2237 10 levels level NNS cord-015306-us58wwmp 2237 11 were be VBD cord-015306-us58wwmp 2237 12 higher high JJR cord-015306-us58wwmp 2237 13 in in IN cord-015306-us58wwmp 2237 14 the the DT cord-015306-us58wwmp 2237 15 FLU flu NN cord-015306-us58wwmp 2237 16 treated treat VBN cord-015306-us58wwmp 2237 17 group group NN cord-015306-us58wwmp 2237 18 compared compare VBN cord-015306-us58wwmp 2237 19 to to IN cord-015306-us58wwmp 2237 20 VEH VEH NNP cord-015306-us58wwmp 2237 21 and and CC cord-015306-us58wwmp 2237 22 FN FN NNP cord-015306-us58wwmp 2237 23 . . . cord-015306-us58wwmp 2238 1 The the DT cord-015306-us58wwmp 2238 2 acute acute JJ cord-015306-us58wwmp 2238 3 vasodilatative vasodilatative NN cord-015306-us58wwmp 2238 4 effect effect NN cord-015306-us58wwmp 2238 5 of of IN cord-015306-us58wwmp 2238 6 FLU FLU NNP cord-015306-us58wwmp 2238 7 30 30 CD cord-015306-us58wwmp 2238 8 minutes minute NNS cord-015306-us58wwmp 2238 9 after after IN cord-015306-us58wwmp 2238 10 treatment treatment NN cord-015306-us58wwmp 2238 11 was be VBD cord-015306-us58wwmp 2238 12 suspended suspend VBN cord-015306-us58wwmp 2238 13 by by IN cord-015306-us58wwmp 2238 14 L l NN cord-015306-us58wwmp 2238 15 - - HYPH cord-015306-us58wwmp 2238 16 NAME NAME NNP cord-015306-us58wwmp 2238 17 and and CC cord-015306-us58wwmp 2238 18 7-NI 7-ni CD cord-015306-us58wwmp 2238 19 and and CC cord-015306-us58wwmp 2238 20 even even RB cord-015306-us58wwmp 2238 21 reversed reverse VBN cord-015306-us58wwmp 2238 22 by by IN cord-015306-us58wwmp 2238 23 L L NNP cord-015306-us58wwmp 2238 24 - - HYPH cord-015306-us58wwmp 2238 25 NIO NIO NNP cord-015306-us58wwmp 2238 26 . . . cord-015306-us58wwmp 2239 1 S1R s1r NN cord-015306-us58wwmp 2239 2 , , , cord-015306-us58wwmp 2239 3 Akt Akt NNP cord-015306-us58wwmp 2239 4 and and CC cord-015306-us58wwmp 2239 5 eNOS enos JJ cord-015306-us58wwmp 2239 6 protein protein NN cord-015306-us58wwmp 2239 7 levels level NNS cord-015306-us58wwmp 2239 8 were be VBD cord-015306-us58wwmp 2239 9 elevated elevate VBN cord-015306-us58wwmp 2239 10 30min 30min NN cord-015306-us58wwmp 2239 11 after after IN cord-015306-us58wwmp 2239 12 FLU flu NN cord-015306-us58wwmp 2239 13 treatment treatment NN cord-015306-us58wwmp 2239 14 , , , cord-015306-us58wwmp 2239 15 while while IN cord-015306-us58wwmp 2239 16 nNOS nnos JJ cord-015306-us58wwmp 2239 17 levels level NNS cord-015306-us58wwmp 2239 18 remained remain VBD cord-015306-us58wwmp 2239 19 unchanged unchanged JJ cord-015306-us58wwmp 2239 20 . . . cord-015306-us58wwmp 2240 1 Discussion discussion NN cord-015306-us58wwmp 2240 2 : : : cord-015306-us58wwmp 2241 1 Pretreatment pretreatment JJ cord-015306-us58wwmp 2241 2 with with IN cord-015306-us58wwmp 2241 3 the the DT cord-015306-us58wwmp 2241 4 S1R s1r NN cord-015306-us58wwmp 2241 5 agonist agonist NN cord-015306-us58wwmp 2241 6 FLU flu NN cord-015306-us58wwmp 2241 7 -used -use VBN cord-015306-us58wwmp 2241 8 chronically chronically RB cord-015306-us58wwmp 2241 9 without without IN cord-015306-us58wwmp 2241 10 notable notable JJ cord-015306-us58wwmp 2241 11 side side NN cord-015306-us58wwmp 2241 12 - - HYPH cord-015306-us58wwmp 2241 13 effects effect NNS cord-015306-us58wwmp 2241 14 -improves -improve NNS cord-015306-us58wwmp 2242 1 postischemic postischemic JJ cord-015306-us58wwmp 2242 2 renal renal JJ cord-015306-us58wwmp 2242 3 perfusion perfusion NN cord-015306-us58wwmp 2242 4 through through IN cord-015306-us58wwmp 2242 5 the the DT cord-015306-us58wwmp 2242 6 activation activation NN cord-015306-us58wwmp 2242 7 of of IN cord-015306-us58wwmp 2242 8 S1R s1r NN cord-015306-us58wwmp 2242 9 -NOS -NOS : cord-015306-us58wwmp 2242 10 system system NN cord-015306-us58wwmp 2242 11 in in IN cord-015306-us58wwmp 2242 12 a a DT cord-015306-us58wwmp 2242 13 time time NN cord-015306-us58wwmp 2242 14 and and CC cord-015306-us58wwmp 2242 15 NOS NOS NNP cord-015306-us58wwmp 2242 16 isoform isoform NN cord-015306-us58wwmp 2242 17 specific specific JJ cord-015306-us58wwmp 2242 18 manner manner NN cord-015306-us58wwmp 2242 19 . . . cord-015306-us58wwmp 2243 1 Based base VBN cord-015306-us58wwmp 2243 2 on on IN cord-015306-us58wwmp 2243 3 this this DT cord-015306-us58wwmp 2243 4 data datum NNS cord-015306-us58wwmp 2243 5 one one PRP cord-015306-us58wwmp 2243 6 can can MD cord-015306-us58wwmp 2243 7 hope hope VB cord-015306-us58wwmp 2243 8 to to TO cord-015306-us58wwmp 2243 9 find find VB cord-015306-us58wwmp 2243 10 a a DT cord-015306-us58wwmp 2243 11 new new JJ cord-015306-us58wwmp 2243 12 therapeutic therapeutic JJ cord-015306-us58wwmp 2243 13 target target NN cord-015306-us58wwmp 2243 14 in in IN cord-015306-us58wwmp 2243 15 the the DT cord-015306-us58wwmp 2243 16 treatment treatment NN cord-015306-us58wwmp 2243 17 of of IN cord-015306-us58wwmp 2243 18 renal renal JJ cord-015306-us58wwmp 2243 19 IR IR NNP cord-015306-us58wwmp 2243 20 damage damage NN cord-015306-us58wwmp 2243 21 through through IN cord-015306-us58wwmp 2243 22 the the DT cord-015306-us58wwmp 2243 23 modulation modulation NN cord-015306-us58wwmp 2243 24 of of IN cord-015306-us58wwmp 2243 25 the the DT cord-015306-us58wwmp 2243 26 S1R. S1R. NNP cord-015306-us58wwmp 2243 27 Methods method NNS cord-015306-us58wwmp 2243 28 : : : cord-015306-us58wwmp 2243 29 36 36 CD cord-015306-us58wwmp 2243 30 SD sd NN cord-015306-us58wwmp 2243 31 rats rat NNS cord-015306-us58wwmp 2243 32 were be VBD cord-015306-us58wwmp 2243 33 randomly randomly RB cord-015306-us58wwmp 2243 34 divided divide VBN cord-015306-us58wwmp 2243 35 into into IN cord-015306-us58wwmp 2243 36 model model NN cord-015306-us58wwmp 2243 37 group group NN cord-015306-us58wwmp 2243 38 , , , cord-015306-us58wwmp 2243 39 intervention intervention NN cord-015306-us58wwmp 2243 40 group group NN cord-015306-us58wwmp 2243 41 and and CC cord-015306-us58wwmp 2243 42 normal normal JJ cord-015306-us58wwmp 2243 43 group group NN cord-015306-us58wwmp 2243 44 , , , cord-015306-us58wwmp 2243 45 12 12 CD cord-015306-us58wwmp 2243 46 rats rat NNS cord-015306-us58wwmp 2243 47 in in IN cord-015306-us58wwmp 2243 48 each each DT cord-015306-us58wwmp 2243 49 group group NN cord-015306-us58wwmp 2243 50 . . . cord-015306-us58wwmp 2244 1 Intraperitoneal intraperitoneal JJ cord-015306-us58wwmp 2244 2 injection injection NN cord-015306-us58wwmp 2244 3 with with IN cord-015306-us58wwmp 2244 4 gentamicin gentamicin NNS cord-015306-us58wwmp 2244 5 for for IN cord-015306-us58wwmp 2244 6 7 7 CD cord-015306-us58wwmp 2244 7 days day NNS cord-015306-us58wwmp 2244 8 to to TO cord-015306-us58wwmp 2244 9 establish establish VB cord-015306-us58wwmp 2244 10 renal renal JJ cord-015306-us58wwmp 2244 11 tubular tubular JJ cord-015306-us58wwmp 2244 12 injury injury NN cord-015306-us58wwmp 2244 13 rat rat NN cord-015306-us58wwmp 2244 14 model model NN cord-015306-us58wwmp 2244 15 . . . cord-015306-us58wwmp 2245 1 Then then RB cord-015306-us58wwmp 2245 2 the the DT cord-015306-us58wwmp 2245 3 intervention intervention NN cord-015306-us58wwmp 2245 4 group group NN cord-015306-us58wwmp 2245 5 rats rat NNS cord-015306-us58wwmp 2245 6 were be VBD cord-015306-us58wwmp 2245 7 transplanted transplant VBN cord-015306-us58wwmp 2245 8 with with IN cord-015306-us58wwmp 2245 9 4×10 4×10 CD cord-015306-us58wwmp 2245 10 6 6 CD cord-015306-us58wwmp 2245 11 /ml /ml . cord-015306-us58wwmp 2245 12 BM BM NNP cord-015306-us58wwmp 2245 13 - - HYPH cord-015306-us58wwmp 2245 14 MSCs msc NNS cord-015306-us58wwmp 2245 15 via via IN cord-015306-us58wwmp 2245 16 tail tail NN cord-015306-us58wwmp 2245 17 vein vein NN cord-015306-us58wwmp 2245 18 . . . cord-015306-us58wwmp 2246 1 7 7 CD cord-015306-us58wwmp 2246 2 days day NNS cord-015306-us58wwmp 2246 3 after after IN cord-015306-us58wwmp 2246 4 transplanted transplant VBN cord-015306-us58wwmp 2246 5 with with IN cord-015306-us58wwmp 2246 6 BM BM NNP cord-015306-us58wwmp 2246 7 - - HYPH cord-015306-us58wwmp 2246 8 MSCs msc NNS cord-015306-us58wwmp 2246 9 , , , cord-015306-us58wwmp 2246 10 took take VBD cord-015306-us58wwmp 2246 11 blood blood NN cord-015306-us58wwmp 2246 12 and and CC cord-015306-us58wwmp 2246 13 kidney kidney NN cord-015306-us58wwmp 2246 14 specimen specimen NN cord-015306-us58wwmp 2246 15 of of IN cord-015306-us58wwmp 2246 16 rats rat NNS cord-015306-us58wwmp 2246 17 for for IN cord-015306-us58wwmp 2246 18 testing testing NN cord-015306-us58wwmp 2246 19 . . . cord-015306-us58wwmp 2247 1 Serum serum NN cord-015306-us58wwmp 2247 2 creatinine creatinine NN cord-015306-us58wwmp 2247 3 ( ( -LRB- cord-015306-us58wwmp 2247 4 SCr SCr NNP cord-015306-us58wwmp 2247 5 ) ) -RRB- cord-015306-us58wwmp 2247 6 , , , cord-015306-us58wwmp 2247 7 urea urea NN cord-015306-us58wwmp 2247 8 ( ( -LRB- cord-015306-us58wwmp 2247 9 BUN bun NN cord-015306-us58wwmp 2247 10 ) ) -RRB- cord-015306-us58wwmp 2247 11 , , , cord-015306-us58wwmp 2247 12 Malondialdehyde Malondialdehyde NNP cord-015306-us58wwmp 2247 13 ( ( -LRB- cord-015306-us58wwmp 2247 14 MDA MDA NNP cord-015306-us58wwmp 2247 15 ) ) -RRB- cord-015306-us58wwmp 2247 16 , , , cord-015306-us58wwmp 2247 17 Superoxide superoxide NN cord-015306-us58wwmp 2247 18 dismutase dismutase NN cord-015306-us58wwmp 2247 19 ( ( -LRB- cord-015306-us58wwmp 2247 20 SOD SOD NNP cord-015306-us58wwmp 2247 21 ) ) -RRB- cord-015306-us58wwmp 2247 22 , , , cord-015306-us58wwmp 2247 23 Glutathione glutathione NN cord-015306-us58wwmp 2247 24 peroxidase peroxidase NN cord-015306-us58wwmp 2247 25 ( ( -LRB- cord-015306-us58wwmp 2247 26 Gpx Gpx NNP cord-015306-us58wwmp 2247 27 ) ) -RRB- cord-015306-us58wwmp 2247 28 , , , cord-015306-us58wwmp 2247 29 Heme Heme NNP cord-015306-us58wwmp 2247 30 oxygenase oxygenase NN cord-015306-us58wwmp 2247 31 -1 -1 NN cord-015306-us58wwmp 2247 32 ( ( -LRB- cord-015306-us58wwmp 2247 33 HO-1 HO-1 NNP cord-015306-us58wwmp 2247 34 ) ) -RRB- cord-015306-us58wwmp 2247 35 were be VBD cord-015306-us58wwmp 2247 36 detected detect VBN cord-015306-us58wwmp 2247 37 by by IN cord-015306-us58wwmp 2247 38 spectrophotometry spectrophotometry NN cord-015306-us58wwmp 2247 39 . . . cord-015306-us58wwmp 2248 1 HE he PRP cord-015306-us58wwmp 2248 2 staining staining NN cord-015306-us58wwmp 2248 3 was be VBD cord-015306-us58wwmp 2248 4 used use VBN cord-015306-us58wwmp 2248 5 to to TO cord-015306-us58wwmp 2248 6 evaluate evaluate VB cord-015306-us58wwmp 2248 7 the the DT cord-015306-us58wwmp 2248 8 change change NN cord-015306-us58wwmp 2248 9 of of IN cord-015306-us58wwmp 2248 10 renal renal JJ cord-015306-us58wwmp 2248 11 tissue tissue NN cord-015306-us58wwmp 2248 12 pathology pathology NN cord-015306-us58wwmp 2248 13 , , , cord-015306-us58wwmp 2248 14 then then RB cord-015306-us58wwmp 2248 15 score score VB cord-015306-us58wwmp 2248 16 the the DT cord-015306-us58wwmp 2248 17 renal renal JJ cord-015306-us58wwmp 2248 18 tubular tubular JJ cord-015306-us58wwmp 2248 19 injury injury NN cord-015306-us58wwmp 2248 20 according accord VBG cord-015306-us58wwmp 2248 21 to to IN cord-015306-us58wwmp 2248 22 the the DT cord-015306-us58wwmp 2248 23 Nangaku Nangaku NNP cord-015306-us58wwmp 2248 24 semiquantitative semiquantitative NN cord-015306-us58wwmp 2248 25 scoring score VBG cord-015306-us58wwmp 2248 26 method method NN cord-015306-us58wwmp 2248 27 . . . cord-015306-us58wwmp 2249 1 TUNEL TUNEL NNP cord-015306-us58wwmp 2249 2 method method NN cord-015306-us58wwmp 2249 3 was be VBD cord-015306-us58wwmp 2249 4 used use VBN cord-015306-us58wwmp 2249 5 to to TO cord-015306-us58wwmp 2249 6 detect detect VB cord-015306-us58wwmp 2249 7 the the DT cord-015306-us58wwmp 2249 8 apoptosis apoptosis NN cord-015306-us58wwmp 2249 9 of of IN cord-015306-us58wwmp 2249 10 epithelial epithelial JJ cord-015306-us58wwmp 2249 11 cell cell NN cord-015306-us58wwmp 2249 12 rate rate NN cord-015306-us58wwmp 2249 13 in in IN cord-015306-us58wwmp 2249 14 renal renal JJ cord-015306-us58wwmp 2249 15 tubular tubular JJ cord-015306-us58wwmp 2249 16 , , , cord-015306-us58wwmp 2249 17 while while IN cord-015306-us58wwmp 2249 18 immunohistochemistry immunohistochemistry NN cord-015306-us58wwmp 2249 19 was be VBD cord-015306-us58wwmp 2249 20 used use VBN cord-015306-us58wwmp 2249 21 to to TO cord-015306-us58wwmp 2249 22 detect detect VB cord-015306-us58wwmp 2249 23 the the DT cord-015306-us58wwmp 2249 24 proliferation proliferation NN cord-015306-us58wwmp 2249 25 of of IN cord-015306-us58wwmp 2249 26 renal renal JJ cord-015306-us58wwmp 2249 27 tubular tubular JJ cord-015306-us58wwmp 2249 28 epithelial epithelial JJ cord-015306-us58wwmp 2249 29 cells cell NNS cord-015306-us58wwmp 2249 30 ( ( -LRB- cord-015306-us58wwmp 2249 31 PCNA PCNA NNS cord-015306-us58wwmp 2249 32 labeling labeling NN cord-015306-us58wwmp 2249 33 index index NN cord-015306-us58wwmp 2249 34 ) ) -RRB- cord-015306-us58wwmp 2249 35 . . . cord-015306-us58wwmp 2250 1 Results result NNS cord-015306-us58wwmp 2250 2 : : : cord-015306-us58wwmp 2251 1 1 1 LS cord-015306-us58wwmp 2251 2 . . . cord-015306-us58wwmp 2251 3 SCr SCr NNS cord-015306-us58wwmp 2251 4 and and CC cord-015306-us58wwmp 2251 5 BUN bun NN cord-015306-us58wwmp 2251 6 of of IN cord-015306-us58wwmp 2251 7 intervention intervention NN cord-015306-us58wwmp 2251 8 group group NN cord-015306-us58wwmp 2251 9 rats rat NNS cord-015306-us58wwmp 2251 10 were be VBD cord-015306-us58wwmp 2251 11 lower low JJR cord-015306-us58wwmp 2251 12 than than IN cord-015306-us58wwmp 2251 13 those those DT cord-015306-us58wwmp 2251 14 in in IN cord-015306-us58wwmp 2251 15 the the DT cord-015306-us58wwmp 2251 16 model model NN cord-015306-us58wwmp 2251 17 group group NN cord-015306-us58wwmp 2251 18 , , , cord-015306-us58wwmp 2251 19 the the DT cord-015306-us58wwmp 2251 20 difference difference NN cord-015306-us58wwmp 2251 21 was be VBD cord-015306-us58wwmp 2251 22 statistically statistically RB cord-015306-us58wwmp 2251 23 significant significant JJ cord-015306-us58wwmp 2252 1 ( ( -LRB- cord-015306-us58wwmp 2252 2 P p NN cord-015306-us58wwmp 2252 3 < < XX cord-015306-us58wwmp 2252 4 0.01 0.01 CD cord-015306-us58wwmp 2252 5 ) ) -RRB- cord-015306-us58wwmp 2253 1 ; ; : cord-015306-us58wwmp 2253 2 2 2 CD cord-015306-us58wwmp 2253 3 . . . cord-015306-us58wwmp 2254 1 Renal renal JJ cord-015306-us58wwmp 2254 2 tubule tubule NN cord-015306-us58wwmp 2254 3 pathological pathological JJ cord-015306-us58wwmp 2254 4 score score NN cord-015306-us58wwmp 2254 5 of of IN cord-015306-us58wwmp 2254 6 intervention intervention NN cord-015306-us58wwmp 2254 7 group group NN cord-015306-us58wwmp 2254 8 rats rat NNS cord-015306-us58wwmp 2254 9 were be VBD cord-015306-us58wwmp 2254 10 lower low JJR cord-015306-us58wwmp 2254 11 than than IN cord-015306-us58wwmp 2254 12 those those DT cord-015306-us58wwmp 2254 13 in in IN cord-015306-us58wwmp 2254 14 the the DT cord-015306-us58wwmp 2254 15 model model NN cord-015306-us58wwmp 2254 16 group group NN cord-015306-us58wwmp 2254 17 , , , cord-015306-us58wwmp 2254 18 the the DT cord-015306-us58wwmp 2254 19 difference difference NN cord-015306-us58wwmp 2254 20 was be VBD cord-015306-us58wwmp 2254 21 statistically statistically RB cord-015306-us58wwmp 2254 22 significant significant JJ cord-015306-us58wwmp 2255 1 ( ( -LRB- cord-015306-us58wwmp 2255 2 P p NN cord-015306-us58wwmp 2255 3 < < XX cord-015306-us58wwmp 2255 4 0.01 0.01 CD cord-015306-us58wwmp 2255 5 ) ) -RRB- cord-015306-us58wwmp 2255 6 ; ; : cord-015306-us58wwmp 2255 7 3 3 CD cord-015306-us58wwmp 2255 8 . . . cord-015306-us58wwmp 2256 1 Apoptosis apoptosis NN cord-015306-us58wwmp 2256 2 ratio ratio NN cord-015306-us58wwmp 2256 3 of of IN cord-015306-us58wwmp 2256 4 renal renal JJ cord-015306-us58wwmp 2256 5 tubular tubular JJ cord-015306-us58wwmp 2256 6 epithelial epithelial JJ cord-015306-us58wwmp 2256 7 cell cell NN cord-015306-us58wwmp 2256 8 in in IN cord-015306-us58wwmp 2256 9 intervention intervention NN cord-015306-us58wwmp 2256 10 group group NN cord-015306-us58wwmp 2256 11 rats rat NNS cord-015306-us58wwmp 2256 12 were be VBD cord-015306-us58wwmp 2256 13 lower low JJR cord-015306-us58wwmp 2256 14 than than IN cord-015306-us58wwmp 2256 15 the the DT cord-015306-us58wwmp 2256 16 model model NN cord-015306-us58wwmp 2256 17 group group NN cord-015306-us58wwmp 2256 18 , , , cord-015306-us58wwmp 2256 19 the the DT cord-015306-us58wwmp 2256 20 difference difference NN cord-015306-us58wwmp 2256 21 was be VBD cord-015306-us58wwmp 2256 22 statistically statistically RB cord-015306-us58wwmp 2256 23 significant significant JJ cord-015306-us58wwmp 2256 24 ( ( -LRB- cord-015306-us58wwmp 2256 25 P<0.01 P<0.01 NNS cord-015306-us58wwmp 2256 26 ) ) -RRB- cord-015306-us58wwmp 2256 27 ; ; : cord-015306-us58wwmp 2257 1 4 4 LS cord-015306-us58wwmp 2257 2 . . . cord-015306-us58wwmp 2258 1 The the DT cord-015306-us58wwmp 2258 2 PCNA PCNA NNP cord-015306-us58wwmp 2258 3 labeling labeling NN cord-015306-us58wwmp 2258 4 index index NN cord-015306-us58wwmp 2258 5 of of IN cord-015306-us58wwmp 2258 6 intervention intervention NN cord-015306-us58wwmp 2258 7 group group NN cord-015306-us58wwmp 2258 8 rats rat NNS cord-015306-us58wwmp 2258 9 were be VBD cord-015306-us58wwmp 2258 10 higher high JJR cord-015306-us58wwmp 2258 11 than than IN cord-015306-us58wwmp 2258 12 those those DT cord-015306-us58wwmp 2258 13 in in IN cord-015306-us58wwmp 2258 14 the the DT cord-015306-us58wwmp 2258 15 model model NN cord-015306-us58wwmp 2258 16 group group NN cord-015306-us58wwmp 2258 17 , , , cord-015306-us58wwmp 2258 18 the the DT cord-015306-us58wwmp 2258 19 difference difference NN cord-015306-us58wwmp 2258 20 was be VBD cord-015306-us58wwmp 2258 21 significant significant JJ cord-015306-us58wwmp 2258 22 ( ( -LRB- cord-015306-us58wwmp 2258 23 P<0.05 P<0.05 NNS cord-015306-us58wwmp 2258 24 ) ) -RRB- cord-015306-us58wwmp 2258 25 ; ; : cord-015306-us58wwmp 2258 26 5 5 CD cord-015306-us58wwmp 2258 27 . . . cord-015306-us58wwmp 2259 1 The the DT cord-015306-us58wwmp 2259 2 MDA MDA NNP cord-015306-us58wwmp 2259 3 level level NN cord-015306-us58wwmp 2259 4 was be VBD cord-015306-us58wwmp 2259 5 significantly significantly RB cord-015306-us58wwmp 2259 6 reduced reduce VBN cord-015306-us58wwmp 2259 7 in in IN cord-015306-us58wwmp 2259 8 intervention intervention NN cord-015306-us58wwmp 2259 9 group group NN cord-015306-us58wwmp 2259 10 rats rat NNS cord-015306-us58wwmp 2259 11 than than IN cord-015306-us58wwmp 2259 12 in in IN cord-015306-us58wwmp 2259 13 the the DT cord-015306-us58wwmp 2259 14 model model NN cord-015306-us58wwmp 2259 15 group group NN cord-015306-us58wwmp 2259 16 ( ( -LRB- cord-015306-us58wwmp 2259 17 P p NN cord-015306-us58wwmp 2259 18 < < XX cord-015306-us58wwmp 2259 19 0.01 0.01 CD cord-015306-us58wwmp 2259 20 ) ) -RRB- cord-015306-us58wwmp 2259 21 ; ; : cord-015306-us58wwmp 2259 22 6 6 CD cord-015306-us58wwmp 2259 23 . . . cord-015306-us58wwmp 2260 1 The the DT cord-015306-us58wwmp 2260 2 SOD sod NN cord-015306-us58wwmp 2260 3 , , , cord-015306-us58wwmp 2260 4 Gpx Gpx NNP cord-015306-us58wwmp 2260 5 and and CC cord-015306-us58wwmp 2260 6 HO-1 HO-1 NNP cord-015306-us58wwmp 2260 7 inintervention inintervention NN cord-015306-us58wwmp 2260 8 group group NN cord-015306-us58wwmp 2260 9 rats rat NNS cord-015306-us58wwmp 2260 10 were be VBD cord-015306-us58wwmp 2260 11 significantly significantly RB cord-015306-us58wwmp 2260 12 increased increase VBN cord-015306-us58wwmp 2260 13 than than IN cord-015306-us58wwmp 2260 14 those those DT cord-015306-us58wwmp 2260 15 in in IN cord-015306-us58wwmp 2260 16 the the DT cord-015306-us58wwmp 2260 17 model model NN cord-015306-us58wwmp 2260 18 group group NN cord-015306-us58wwmp 2260 19 ( ( -LRB- cord-015306-us58wwmp 2260 20 P p NN cord-015306-us58wwmp 2260 21 < < XX cord-015306-us58wwmp 2260 22 0.01 0.01 CD cord-015306-us58wwmp 2260 23 ) ) -RRB- cord-015306-us58wwmp 2260 24 . . . cord-015306-us58wwmp 2261 1 Conclusion conclusion NN cord-015306-us58wwmp 2261 2 : : : cord-015306-us58wwmp 2262 1 Antioxidant antioxidant NN cord-015306-us58wwmp 2262 2 factors factor NNS cord-015306-us58wwmp 2262 3 such such JJ cord-015306-us58wwmp 2262 4 as as IN cord-015306-us58wwmp 2262 5 SOD SOD NNP cord-015306-us58wwmp 2262 6 , , , cord-015306-us58wwmp 2262 7 Gpx Gpx NNP cord-015306-us58wwmp 2262 8 and and CC cord-015306-us58wwmp 2262 9 HO-1 HO-1 NNP cord-015306-us58wwmp 2262 10 were be VBD cord-015306-us58wwmp 2262 11 significant significant JJ cord-015306-us58wwmp 2262 12 increased increase VBN cord-015306-us58wwmp 2262 13 after after IN cord-015306-us58wwmp 2262 14 BM BM NNP cord-015306-us58wwmp 2262 15 - - HYPH cord-015306-us58wwmp 2262 16 MSCs msc NNS cord-015306-us58wwmp 2262 17 transplanted transplant VBN cord-015306-us58wwmp 2262 18 into into IN cord-015306-us58wwmp 2262 19 rats rat NNS cord-015306-us58wwmp 2262 20 . . . cord-015306-us58wwmp 2263 1 It -PRON- PRP cord-015306-us58wwmp 2263 2 means mean VBZ cord-015306-us58wwmp 2263 3 that that IN cord-015306-us58wwmp 2263 4 BM BM NNP cord-015306-us58wwmp 2263 5 - - HYPH cord-015306-us58wwmp 2263 6 MSCs mscs NN cord-015306-us58wwmp 2263 7 may may MD cord-015306-us58wwmp 2263 8 have have VB cord-015306-us58wwmp 2263 9 antioxidant antioxidant JJ cord-015306-us58wwmp 2263 10 effect effect NN cord-015306-us58wwmp 2263 11 to to TO cord-015306-us58wwmp 2263 12 heal heal VB cord-015306-us58wwmp 2263 13 the the DT cord-015306-us58wwmp 2263 14 renal renal JJ cord-015306-us58wwmp 2263 15 tubular tubular JJ cord-015306-us58wwmp 2263 16 damage damage NN cord-015306-us58wwmp 2263 17 . . . cord-015306-us58wwmp 2264 1 The the DT cord-015306-us58wwmp 2264 2 effect effect NN cord-015306-us58wwmp 2264 3 on on IN cord-015306-us58wwmp 2264 4 regeneration regeneration NN cord-015306-us58wwmp 2264 5 and and CC cord-015306-us58wwmp 2264 6 repair repair NN cord-015306-us58wwmp 2264 7 in in IN cord-015306-us58wwmp 2264 8 renal renal JJ cord-015306-us58wwmp 2264 9 tubular tubular JJ cord-015306-us58wwmp 2264 10 epithelial epithelial JJ cord-015306-us58wwmp 2264 11 cell cell NN cord-015306-us58wwmp 2264 12 after after IN cord-015306-us58wwmp 2264 13 injury injury NN cord-015306-us58wwmp 2264 14 deal deal NN cord-015306-us58wwmp 2264 15 with with IN cord-015306-us58wwmp 2264 16 AT2R at2r ADD cord-015306-us58wwmp 2264 17 antagonist antagonist NN cord-015306-us58wwmp 2264 18 PD123319 pd123319 NN cord-015306-us58wwmp 2264 19 Objective objective NN cord-015306-us58wwmp 2264 20 : : : cord-015306-us58wwmp 2264 21 To to TO cord-015306-us58wwmp 2264 22 study study VB cord-015306-us58wwmp 2264 23 the the DT cord-015306-us58wwmp 2264 24 effect effect NN cord-015306-us58wwmp 2264 25 of of IN cord-015306-us58wwmp 2264 26 proliferation proliferation NN cord-015306-us58wwmp 2264 27 of of IN cord-015306-us58wwmp 2264 28 renal renal JJ cord-015306-us58wwmp 2264 29 tubular tubular JJ cord-015306-us58wwmp 2264 30 epithelial epithelial JJ cord-015306-us58wwmp 2264 31 cell cell NN cord-015306-us58wwmp 2264 32 after after IN cord-015306-us58wwmp 2264 33 injury injury NN cord-015306-us58wwmp 2264 34 deal deal NN cord-015306-us58wwmp 2264 35 with with IN cord-015306-us58wwmp 2264 36 AT2R at2r ADD cord-015306-us58wwmp 2264 37 antagonist antagonist NN cord-015306-us58wwmp 2264 38 PD123319,And pd123319,and NN cord-015306-us58wwmp 2264 39 to to TO cord-015306-us58wwmp 2264 40 explore explore VB cord-015306-us58wwmp 2264 41 the the DT cord-015306-us58wwmp 2264 42 function function NN cord-015306-us58wwmp 2264 43 and and CC cord-015306-us58wwmp 2264 44 mechanism mechanism NN cord-015306-us58wwmp 2264 45 of of IN cord-015306-us58wwmp 2264 46 AT2R AT2R NNS cord-015306-us58wwmp 2264 47 in in IN cord-015306-us58wwmp 2264 48 the the DT cord-015306-us58wwmp 2264 49 regeneration regeneration NN cord-015306-us58wwmp 2264 50 and and CC cord-015306-us58wwmp 2264 51 repair repair NN cord-015306-us58wwmp 2264 52 after after IN cord-015306-us58wwmp 2264 53 acute acute JJ cord-015306-us58wwmp 2264 54 kidney kidney NN cord-015306-us58wwmp 2264 55 injury injury NN cord-015306-us58wwmp 2264 56 . . . cord-015306-us58wwmp 2265 1 Methods method NNS cord-015306-us58wwmp 2265 2 : : : cord-015306-us58wwmp 2265 3 To to TO cord-015306-us58wwmp 2265 4 establish establish VB cord-015306-us58wwmp 2265 5 the the DT cord-015306-us58wwmp 2265 6 human human JJ cord-015306-us58wwmp 2265 7 renal renal JJ cord-015306-us58wwmp 2265 8 proximal proximal JJ cord-015306-us58wwmp 2265 9 tubule tubule NN cord-015306-us58wwmp 2265 10 cells cell NNS cord-015306-us58wwmp 2265 11 ( ( -LRB- cord-015306-us58wwmp 2265 12 HK-2 HK-2 NNP cord-015306-us58wwmp 2265 13 cells cell NNS cord-015306-us58wwmp 2265 14 ) ) -RRB- cord-015306-us58wwmp 2265 15 hypoxia hypoxia NN cord-015306-us58wwmp 2265 16 /reoxygenation /reoxygenation . cord-015306-us58wwmp 2265 17 model model NN cord-015306-us58wwmp 2265 18 . . . cord-015306-us58wwmp 2266 1 HK-2 HK-2 NNP cord-015306-us58wwmp 2267 1 cells cell NNS cord-015306-us58wwmp 2267 2 were be VBD cord-015306-us58wwmp 2267 3 divided divide VBN cord-015306-us58wwmp 2267 4 into into IN cord-015306-us58wwmp 2267 5 two two CD cord-015306-us58wwmp 2267 6 groups group NNS cord-015306-us58wwmp 2267 7 . . . cord-015306-us58wwmp 2268 1 ( ( -LRB- cord-015306-us58wwmp 2268 2 1 1 LS cord-015306-us58wwmp 2268 3 ) ) -RRB- cord-015306-us58wwmp 2268 4 ( ( -LRB- cord-015306-us58wwmp 2268 5 1 1 CD cord-015306-us58wwmp 2268 6 ) ) -RRB- cord-015306-us58wwmp 2269 1 These these DT cord-015306-us58wwmp 2269 2 results result NNS cord-015306-us58wwmp 2269 3 suggest suggest VBP cord-015306-us58wwmp 2269 4 that that IN cord-015306-us58wwmp 2269 5 the the DT cord-015306-us58wwmp 2269 6 renal renal JJ cord-015306-us58wwmp 2269 7 proximal proximal JJ cord-015306-us58wwmp 2269 8 tubule tubule NN cord-015306-us58wwmp 2269 9 epithelial epithelial JJ cord-015306-us58wwmp 2269 10 cells cell NNS cord-015306-us58wwmp 2269 11 after after IN cord-015306-us58wwmp 2269 12 hypoxia hypoxia NN cord-015306-us58wwmp 2269 13 / / SYM cord-015306-us58wwmp 2269 14 reoxygenation reoxygenation NN cord-015306-us58wwmp 2269 15 can can MD cord-015306-us58wwmp 2269 16 be be VB cord-015306-us58wwmp 2269 17 simulated simulate VBN cord-015306-us58wwmp 2269 18 tubular tubular JJ cord-015306-us58wwmp 2269 19 epithelial epithelial JJ cord-015306-us58wwmp 2269 20 cell cell NN cord-015306-us58wwmp 2269 21 process process NN cord-015306-us58wwmp 2269 22 damage damage NN cord-015306-us58wwmp 2269 23 ; ; : cord-015306-us58wwmp 2269 24 ( ( -LRB- cord-015306-us58wwmp 2269 25 2 2 LS cord-015306-us58wwmp 2269 26 ) ) -RRB- cord-015306-us58wwmp 2270 1 The the DT cord-015306-us58wwmp 2270 2 proliferation proliferation NN cord-015306-us58wwmp 2270 3 of of IN cord-015306-us58wwmp 2270 4 renal renal JJ cord-015306-us58wwmp 2270 5 tubular tubular JJ cord-015306-us58wwmp 2270 6 epithelial epithelial JJ cord-015306-us58wwmp 2270 7 cell cell NN cord-015306-us58wwmp 2270 8 after after IN cord-015306-us58wwmp 2270 9 injury injury NN cord-015306-us58wwmp 2270 10 was be VBD cord-015306-us58wwmp 2270 11 inhibited inhibit VBN cord-015306-us58wwmp 2270 12 by by IN cord-015306-us58wwmp 2270 13 PD123319.AT2R PD123319.AT2R NNP cord-015306-us58wwmp 2270 14 may may MD cord-015306-us58wwmp 2270 15 play play VB cord-015306-us58wwmp 2270 16 an an DT cord-015306-us58wwmp 2270 17 important important JJ cord-015306-us58wwmp 2270 18 role role NN cord-015306-us58wwmp 2270 19 in in IN cord-015306-us58wwmp 2270 20 the the DT cord-015306-us58wwmp 2270 21 regeneration regeneration NN cord-015306-us58wwmp 2270 22 and and CC cord-015306-us58wwmp 2270 23 repair repair NN cord-015306-us58wwmp 2270 24 in in IN cord-015306-us58wwmp 2270 25 the the DT cord-015306-us58wwmp 2270 26 kidney kidney NN cord-015306-us58wwmp 2270 27 by by IN cord-015306-us58wwmp 2270 28 means mean NNS cord-015306-us58wwmp 2270 29 of of IN cord-015306-us58wwmp 2270 30 promoting promote VBG cord-015306-us58wwmp 2270 31 the the DT cord-015306-us58wwmp 2270 32 proliferation proliferation NN cord-015306-us58wwmp 2270 33 of of IN cord-015306-us58wwmp 2270 34 renal renal JJ cord-015306-us58wwmp 2270 35 tubular tubular JJ cord-015306-us58wwmp 2270 36 epithelial epithelial JJ cord-015306-us58wwmp 2270 37 cells cell NNS cord-015306-us58wwmp 2270 38 . . . cord-015306-us58wwmp 2271 1 ( ( -LRB- cord-015306-us58wwmp 2271 2 3 3 LS cord-015306-us58wwmp 2271 3 ) ) -RRB- cord-015306-us58wwmp 2271 4 ARB ARB NNP cord-015306-us58wwmp 2271 5 have have VBP cord-015306-us58wwmp 2271 6 no no DT cord-015306-us58wwmp 2271 7 significantly significantly RB cord-015306-us58wwmp 2271 8 inhibit inhibit VB cord-015306-us58wwmp 2271 9 the the DT cord-015306-us58wwmp 2271 10 proliferation proliferation NN cord-015306-us58wwmp 2271 11 of of IN cord-015306-us58wwmp 2271 12 renal renal JJ cord-015306-us58wwmp 2271 13 tubular tubular JJ cord-015306-us58wwmp 2271 14 epithelial epithelial JJ cord-015306-us58wwmp 2271 15 cell cell NN cord-015306-us58wwmp 2271 16 after after IN cord-015306-us58wwmp 2271 17 injury injury NN cord-015306-us58wwmp 2271 18 , , , cord-015306-us58wwmp 2271 19 suggesting suggest VBG cord-015306-us58wwmp 2271 20 that that IN cord-015306-us58wwmp 2271 21 AT1R AT1R NNP cord-015306-us58wwmp 2271 22 may may MD cord-015306-us58wwmp 2271 23 not not RB cord-015306-us58wwmp 2271 24 have have VB cord-015306-us58wwmp 2271 25 major major JJ cord-015306-us58wwmp 2271 26 role role NN cord-015306-us58wwmp 2271 27 in in IN cord-015306-us58wwmp 2271 28 regeneration regeneration NN cord-015306-us58wwmp 2271 29 and and CC cord-015306-us58wwmp 2271 30 repair repair NN cord-015306-us58wwmp 2271 31 after after IN cord-015306-us58wwmp 2271 32 acute acute JJ cord-015306-us58wwmp 2271 33 kidney kidney NN cord-015306-us58wwmp 2271 34 injury injury NN cord-015306-us58wwmp 2271 35 . . . cord-015306-us58wwmp 2272 1 The the DT cord-015306-us58wwmp 2272 2 effect effect NN cord-015306-us58wwmp 2272 3 and and CC cord-015306-us58wwmp 2272 4 mechanism mechanism NN cord-015306-us58wwmp 2272 5 on on IN cord-015306-us58wwmp 2272 6 regeneration regeneration NN cord-015306-us58wwmp 2272 7 and and CC cord-015306-us58wwmp 2272 8 repair repair NN cord-015306-us58wwmp 2272 9 in in IN cord-015306-us58wwmp 2272 10 renal renal JJ cord-015306-us58wwmp 2272 11 tubular tubular JJ cord-015306-us58wwmp 2272 12 epithelial epithelial JJ cord-015306-us58wwmp 2272 13 cell cell NN cord-015306-us58wwmp 2272 14 after after IN cord-015306-us58wwmp 2272 15 injury injury NN cord-015306-us58wwmp 2272 16 by by IN cord-015306-us58wwmp 2272 17 the the DT cord-015306-us58wwmp 2272 18 inhibitory inhibitory JJ cord-015306-us58wwmp 2272 19 proliferation proliferation NN cord-015306-us58wwmp 2272 20 effect effect NN cord-015306-us58wwmp 2272 21 of of IN cord-015306-us58wwmp 2272 22 ACEI ACEI NNP cord-015306-us58wwmp 2272 23 and and CC cord-015306-us58wwmp 2272 24 ARB ARB NNP cord-015306-us58wwmp 2272 25 Objective Objective NNP cord-015306-us58wwmp 2272 26 : : : cord-015306-us58wwmp 2272 27 To to TO cord-015306-us58wwmp 2272 28 study study VB cord-015306-us58wwmp 2272 29 the the DT cord-015306-us58wwmp 2272 30 effect effect NN cord-015306-us58wwmp 2272 31 of of IN cord-015306-us58wwmp 2272 32 regeneration regeneration NN cord-015306-us58wwmp 2272 33 and and CC cord-015306-us58wwmp 2272 34 repair repair NN cord-015306-us58wwmp 2272 35 of of IN cord-015306-us58wwmp 2272 36 renal renal JJ cord-015306-us58wwmp 2272 37 tubular tubular JJ cord-015306-us58wwmp 2272 38 epithelial epithelial JJ cord-015306-us58wwmp 2272 39 cell cell NN cord-015306-us58wwmp 2272 40 after after IN cord-015306-us58wwmp 2272 41 injury injury NN cord-015306-us58wwmp 2272 42 deal deal NN cord-015306-us58wwmp 2272 43 with with IN cord-015306-us58wwmp 2272 44 fosinopril fosinopril NN cord-015306-us58wwmp 2272 45 and and CC cord-015306-us58wwmp 2272 46 valsartan valsartan NNP cord-015306-us58wwmp 2272 47 , , , cord-015306-us58wwmp 2272 48 And and CC cord-015306-us58wwmp 2272 49 to to TO cord-015306-us58wwmp 2272 50 explore explore VB cord-015306-us58wwmp 2272 51 the the DT cord-015306-us58wwmp 2272 52 function function NN cord-015306-us58wwmp 2272 53 and and CC cord-015306-us58wwmp 2272 54 mechanism mechanism NN cord-015306-us58wwmp 2272 55 of of IN cord-015306-us58wwmp 2272 56 ACEI ACEI NNP cord-015306-us58wwmp 2272 57 and and CC cord-015306-us58wwmp 2272 58 ARB ARB NNP cord-015306-us58wwmp 2272 59 induced induce VBD cord-015306-us58wwmp 2272 60 acute acute JJ cord-015306-us58wwmp 2272 61 kidney kidney NN cord-015306-us58wwmp 2272 62 injury injury NN cord-015306-us58wwmp 2272 63 by by IN cord-015306-us58wwmp 2272 64 suppressing suppress VBG cord-015306-us58wwmp 2272 65 proliferation proliferation NN cord-015306-us58wwmp 2272 66 . . . cord-015306-us58wwmp 2273 1 Objective objective NN cord-015306-us58wwmp 2273 2 : : : cord-015306-us58wwmp 2274 1 Ischemia ischemia NN cord-015306-us58wwmp 2274 2 - - HYPH cord-015306-us58wwmp 2274 3 reperfusion reperfusion NN cord-015306-us58wwmp 2274 4 injury injury NN cord-015306-us58wwmp 2274 5 ( ( -LRB- cord-015306-us58wwmp 2274 6 IRI IRI NNP cord-015306-us58wwmp 2274 7 ) ) -RRB- cord-015306-us58wwmp 2274 8 is be VBZ cord-015306-us58wwmp 2274 9 a a DT cord-015306-us58wwmp 2274 10 major major JJ cord-015306-us58wwmp 2274 11 cause cause NN cord-015306-us58wwmp 2274 12 of of IN cord-015306-us58wwmp 2274 13 acute acute JJ cord-015306-us58wwmp 2274 14 kidney kidney NN cord-015306-us58wwmp 2274 15 injury injury NN cord-015306-us58wwmp 2274 16 ( ( -LRB- cord-015306-us58wwmp 2274 17 AKI AKI NNP cord-015306-us58wwmp 2274 18 ) ) -RRB- cord-015306-us58wwmp 2274 19 and and CC cord-015306-us58wwmp 2274 20 both both DT cord-015306-us58wwmp 2274 21 innate innate JJ cord-015306-us58wwmp 2274 22 and and CC cord-015306-us58wwmp 2274 23 adaptive adaptive JJ cord-015306-us58wwmp 2274 24 immunity immunity NN cord-015306-us58wwmp 2274 25 contribute contribute VBP cord-015306-us58wwmp 2274 26 to to IN cord-015306-us58wwmp 2274 27 the the DT cord-015306-us58wwmp 2274 28 pathogenesis pathogenesis NN cord-015306-us58wwmp 2274 29 . . . cord-015306-us58wwmp 2275 1 T t NN cord-015306-us58wwmp 2275 2 cell cell NN cord-015306-us58wwmp 2275 3 immunoglobulin-3 immunoglobulin-3 NN cord-015306-us58wwmp 2275 4 ( ( -LRB- cord-015306-us58wwmp 2275 5 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2275 6 ) ) -RRB- cord-015306-us58wwmp 2275 7 has have VBZ cord-015306-us58wwmp 2275 8 been be VBN cord-015306-us58wwmp 2275 9 reported report VBN cord-015306-us58wwmp 2275 10 as as IN cord-015306-us58wwmp 2275 11 an an DT cord-015306-us58wwmp 2275 12 important important JJ cord-015306-us58wwmp 2275 13 regulatory regulatory JJ cord-015306-us58wwmp 2275 14 molecule molecule NN cord-015306-us58wwmp 2275 15 and and CC cord-015306-us58wwmp 2275 16 plays play VBZ cord-015306-us58wwmp 2275 17 a a DT cord-015306-us58wwmp 2275 18 pivotal pivotal JJ cord-015306-us58wwmp 2275 19 role role NN cord-015306-us58wwmp 2275 20 in in IN cord-015306-us58wwmp 2275 21 several several JJ cord-015306-us58wwmp 2275 22 inflammatory inflammatory JJ cord-015306-us58wwmp 2275 23 diseases disease NNS cord-015306-us58wwmp 2275 24 . . . cord-015306-us58wwmp 2276 1 However however RB cord-015306-us58wwmp 2276 2 , , , cord-015306-us58wwmp 2276 3 it -PRON- PRP cord-015306-us58wwmp 2276 4 keeps keep VBZ cord-015306-us58wwmp 2276 5 unknown unknown JJ cord-015306-us58wwmp 2276 6 whether whether IN cord-015306-us58wwmp 2276 7 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2276 8 is be VBZ cord-015306-us58wwmp 2276 9 involved involve VBN cord-015306-us58wwmp 2276 10 in in IN cord-015306-us58wwmp 2276 11 renal renal JJ cord-015306-us58wwmp 2276 12 IRI IRI NNP cord-015306-us58wwmp 2276 13 . . . cord-015306-us58wwmp 2277 1 To to TO cord-015306-us58wwmp 2277 2 investigate investigate VB cord-015306-us58wwmp 2277 3 the the DT cord-015306-us58wwmp 2277 4 expression expression NN cord-015306-us58wwmp 2277 5 of of IN cord-015306-us58wwmp 2277 6 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2277 7 on on IN cord-015306-us58wwmp 2277 8 kidney kidney NN cord-015306-us58wwmp 2277 9 mononuclear mononuclear NN cord-015306-us58wwmp 2277 10 cells cell NNS cord-015306-us58wwmp 2277 11 ( ( -LRB- cord-015306-us58wwmp 2277 12 KMNCs kmnc NNS cord-015306-us58wwmp 2277 13 ) ) -RRB- cord-015306-us58wwmp 2277 14 from from IN cord-015306-us58wwmp 2277 15 mice mouse NNS cord-015306-us58wwmp 2277 16 with with IN cord-015306-us58wwmp 2277 17 renal renal JJ cord-015306-us58wwmp 2277 18 IRI IRI NNP cord-015306-us58wwmp 2277 19 and and CC cord-015306-us58wwmp 2277 20 explored explore VBD cord-015306-us58wwmp 2277 21 its -PRON- PRP$ cord-015306-us58wwmp 2277 22 role role NN cord-015306-us58wwmp 2277 23 in in IN cord-015306-us58wwmp 2277 24 the the DT cord-015306-us58wwmp 2277 25 pathogenesis pathogenesis NN cord-015306-us58wwmp 2277 26 of of IN cord-015306-us58wwmp 2277 27 renal renal JJ cord-015306-us58wwmp 2277 28 IRI IRI NNP cord-015306-us58wwmp 2277 29 . . . cord-015306-us58wwmp 2278 1 Methods method NNS cord-015306-us58wwmp 2278 2 : : : cord-015306-us58wwmp 2279 1 The the DT cord-015306-us58wwmp 2279 2 left left JJ cord-015306-us58wwmp 2279 3 renal renal JJ cord-015306-us58wwmp 2279 4 pedicle pedicle NN cord-015306-us58wwmp 2279 5 was be VBD cord-015306-us58wwmp 2279 6 clamped clamp VBN cord-015306-us58wwmp 2279 7 in in IN cord-015306-us58wwmp 2279 8 C57BL6 C57BL6 NNP cord-015306-us58wwmp 2279 9 mice mouse NNS cord-015306-us58wwmp 2279 10 for for IN cord-015306-us58wwmp 2279 11 45 45 CD cord-015306-us58wwmp 2279 12 min min NN cord-015306-us58wwmp 2279 13 , , , cord-015306-us58wwmp 2279 14 followed follow VBN cord-015306-us58wwmp 2279 15 by by IN cord-015306-us58wwmp 2279 16 reperfusion reperfusion NN cord-015306-us58wwmp 2279 17 . . . cord-015306-us58wwmp 2280 1 Animals animal NNS cord-015306-us58wwmp 2280 2 were be VBD cord-015306-us58wwmp 2280 3 sacrificed sacrifice VBN cord-015306-us58wwmp 2280 4 at at IN cord-015306-us58wwmp 2280 5 baseline baseline NN cord-015306-us58wwmp 2280 6 , , , cord-015306-us58wwmp 2280 7 day day NN cord-015306-us58wwmp 2280 8 1,3 1,3 CD cord-015306-us58wwmp 2280 9 . . . cord-015306-us58wwmp 2281 1 Flow flow NN cord-015306-us58wwmp 2281 2 cytometry cytometry NN cord-015306-us58wwmp 2281 3 was be VBD cord-015306-us58wwmp 2281 4 used use VBN cord-015306-us58wwmp 2281 5 to to TO cord-015306-us58wwmp 2281 6 quantify quantify VB cord-015306-us58wwmp 2281 7 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2281 8 expression expression NN cord-015306-us58wwmp 2281 9 on on IN cord-015306-us58wwmp 2281 10 KMNCs kmnc NNS cord-015306-us58wwmp 2281 11 , , , cord-015306-us58wwmp 2281 12 CD4 CD4 NNP cord-015306-us58wwmp 2281 13 + + CC cord-015306-us58wwmp 2281 14 T T NNP cord-015306-us58wwmp 2281 15 cell cell NN cord-015306-us58wwmp 2281 16 , , , cord-015306-us58wwmp 2281 17 CD8 CD8 NNP cord-015306-us58wwmp 2281 18 + + CC cord-015306-us58wwmp 2281 19 T T NNP cord-015306-us58wwmp 2281 20 cell cell NN cord-015306-us58wwmp 2281 21 , , . cord-015306-us58wwmp 2282 1 Foxp3 foxp3 JJ cord-015306-us58wwmp 2282 2 + + CC cord-015306-us58wwmp 2282 3 Tregs Tregs NNP cord-015306-us58wwmp 2282 4 and and CC cord-015306-us58wwmp 2282 5 CD19 CD19 NNP cord-015306-us58wwmp 2282 6 + + CC cord-015306-us58wwmp 2282 7 B b NN cord-015306-us58wwmp 2282 8 cell cell NN cord-015306-us58wwmp 2282 9 . . . cord-015306-us58wwmp 2283 1 The the DT cord-015306-us58wwmp 2283 2 levels level NNS cord-015306-us58wwmp 2283 3 of of IN cord-015306-us58wwmp 2283 4 TNF TNF NNP cord-015306-us58wwmp 2283 5 - - HYPH cord-015306-us58wwmp 2283 6 α α NNP cord-015306-us58wwmp 2283 7 , , , cord-015306-us58wwmp 2283 8 IFN IFN NNP cord-015306-us58wwmp 2283 9 - - HYPH cord-015306-us58wwmp 2283 10 γ γ NNP cord-015306-us58wwmp 2283 11 , , , cord-015306-us58wwmp 2283 12 IL-4 IL-4 NNP cord-015306-us58wwmp 2283 13 and and CC cord-015306-us58wwmp 2283 14 IL-10 IL-10 NNP cord-015306-us58wwmp 2283 15 in in IN cord-015306-us58wwmp 2283 16 kidney kidney NN cord-015306-us58wwmp 2283 17 tissue tissue NN cord-015306-us58wwmp 2283 18 were be VBD cord-015306-us58wwmp 2283 19 measured measure VBN cord-015306-us58wwmp 2283 20 using use VBG cord-015306-us58wwmp 2283 21 ELISA ELISA NNP cord-015306-us58wwmp 2283 22 . . . cord-015306-us58wwmp 2284 1 Results result NNS cord-015306-us58wwmp 2284 2 : : : cord-015306-us58wwmp 2285 1 At at IN cord-015306-us58wwmp 2285 2 day day NN cord-015306-us58wwmp 2285 3 1 1 CD cord-015306-us58wwmp 2285 4 , , , cord-015306-us58wwmp 2285 5 the the DT cord-015306-us58wwmp 2285 6 increased increase VBN cord-015306-us58wwmp 2285 7 expression expression NN cord-015306-us58wwmp 2285 8 of of IN cord-015306-us58wwmp 2285 9 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2285 10 on on IN cord-015306-us58wwmp 2285 11 KMNCs kmnc NNS cord-015306-us58wwmp 2285 12 , , , cord-015306-us58wwmp 2285 13 CD4 CD4 NNP cord-015306-us58wwmp 2285 14 + + CC cord-015306-us58wwmp 2285 15 T T NNP cord-015306-us58wwmp 2285 16 cell cell NN cord-015306-us58wwmp 2285 17 , , , cord-015306-us58wwmp 2285 18 CD8 CD8 NNP cord-015306-us58wwmp 2285 19 + + CC cord-015306-us58wwmp 2285 20 T T NNP cord-015306-us58wwmp 2285 21 cell cell NN cord-015306-us58wwmp 2285 22 , , , cord-015306-us58wwmp 2285 23 Foxp3 foxp3 JJ cord-015306-us58wwmp 2285 24 + + CC cord-015306-us58wwmp 2285 25 Tregs Tregs NNP cord-015306-us58wwmp 2285 26 in in IN cord-015306-us58wwmp 2285 27 the the DT cord-015306-us58wwmp 2285 28 injured injure VBN cord-015306-us58wwmp 2285 29 kidney kidney NN cord-015306-us58wwmp 2285 30 from from IN cord-015306-us58wwmp 2285 31 mice mouse NNS cord-015306-us58wwmp 2285 32 with with IN cord-015306-us58wwmp 2285 33 renal renal JJ cord-015306-us58wwmp 2285 34 IRI IRI NNP cord-015306-us58wwmp 2285 35 compared compare VBN cord-015306-us58wwmp 2285 36 to to IN cord-015306-us58wwmp 2285 37 those those DT cord-015306-us58wwmp 2285 38 from from IN cord-015306-us58wwmp 2285 39 uninjured uninjured JJ cord-015306-us58wwmp 2285 40 kidney kidney NN cord-015306-us58wwmp 2285 41 tissues tissue NNS cord-015306-us58wwmp 2285 42 and and CC cord-015306-us58wwmp 2285 43 baseline baseline JJ cord-015306-us58wwmp 2285 44 ( ( -LRB- cord-015306-us58wwmp 2285 45 P<0 P<0 NNP cord-015306-us58wwmp 2285 46 . . . cord-015306-us58wwmp 2285 47 05 05 CD cord-015306-us58wwmp 2285 48 ) ) -RRB- cord-015306-us58wwmp 2285 49 . . . cord-015306-us58wwmp 2286 1 Percentage percentage NN cord-015306-us58wwmp 2286 2 of of IN cord-015306-us58wwmp 2286 3 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2286 4 + + CC cord-015306-us58wwmp 2286 5 cells cell NNS cord-015306-us58wwmp 2286 6 in in IN cord-015306-us58wwmp 2286 7 KMNCs kmnc NNS cord-015306-us58wwmp 2286 8 showed show VBD cord-015306-us58wwmp 2286 9 an an DT cord-015306-us58wwmp 2286 10 inverse inverse JJ cord-015306-us58wwmp 2286 11 correlation correlation NN cord-015306-us58wwmp 2286 12 with with IN cord-015306-us58wwmp 2286 13 kidney kidney NN cord-015306-us58wwmp 2286 14 injury injury NN cord-015306-us58wwmp 2286 15 score score NN cord-015306-us58wwmp 2286 16 and and CC cord-015306-us58wwmp 2286 17 kidney kidney NN cord-015306-us58wwmp 2286 18 TNF TNF NNP cord-015306-us58wwmp 2286 19 - - HYPH cord-015306-us58wwmp 2286 20 α α NNP cord-015306-us58wwmp 2286 21 level level NN cord-015306-us58wwmp 2286 22 . . . cord-015306-us58wwmp 2287 1 Similar similar JJ cord-015306-us58wwmp 2287 2 negative negative JJ cord-015306-us58wwmp 2287 3 correlations correlation NNS cord-015306-us58wwmp 2287 4 were be VBD cord-015306-us58wwmp 2287 5 found find VBN cord-015306-us58wwmp 2287 6 between between IN cord-015306-us58wwmp 2287 7 kidney kidney NN cord-015306-us58wwmp 2287 8 injury injury NN cord-015306-us58wwmp 2287 9 score score NN cord-015306-us58wwmp 2287 10 and and CC cord-015306-us58wwmp 2287 11 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2287 12 levels level NNS cord-015306-us58wwmp 2287 13 on on IN cord-015306-us58wwmp 2287 14 CD4 CD4 NNP cord-015306-us58wwmp 2287 15 + + CC cord-015306-us58wwmp 2287 16 T T NNP cord-015306-us58wwmp 2287 17 , , , cord-015306-us58wwmp 2287 18 CD8 CD8 NNP cord-015306-us58wwmp 2287 19 + + CC cord-015306-us58wwmp 2287 20 T T NNP cord-015306-us58wwmp 2287 21 cells cell NNS cord-015306-us58wwmp 2287 22 . . . cord-015306-us58wwmp 2288 1 Consistently consistently RB cord-015306-us58wwmp 2288 2 , , , cord-015306-us58wwmp 2288 3 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2288 4 expression expression NN cord-015306-us58wwmp 2288 5 on on IN cord-015306-us58wwmp 2288 6 CD3 CD3 NNP cord-015306-us58wwmp 2288 7 + + CC cord-015306-us58wwmp 2288 8 T T NNP cord-015306-us58wwmp 2288 9 cells cell NNS cord-015306-us58wwmp 2288 10 was be VBD cord-015306-us58wwmp 2288 11 further further RB cord-015306-us58wwmp 2288 12 increased increase VBN cord-015306-us58wwmp 2288 13 in in IN cord-015306-us58wwmp 2288 14 mice mouse NNS cord-015306-us58wwmp 2288 15 at at IN cord-015306-us58wwmp 2288 16 day day NN cord-015306-us58wwmp 2288 17 3 3 CD cord-015306-us58wwmp 2288 18 . . . cord-015306-us58wwmp 2289 1 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2289 2 expression expression NN cord-015306-us58wwmp 2289 3 on on IN cord-015306-us58wwmp 2290 1 Foxp3 foxp3 JJ cord-015306-us58wwmp 2290 2 + + CC cord-015306-us58wwmp 2290 3 Tregs Tregs NNP cord-015306-us58wwmp 2290 4 negatively negatively RB cord-015306-us58wwmp 2290 5 correlates correlate VBZ cord-015306-us58wwmp 2290 6 with with IN cord-015306-us58wwmp 2290 7 kindey kindey NNP cord-015306-us58wwmp 2290 8 TNF TNF NNP cord-015306-us58wwmp 2290 9 - - HYPH cord-015306-us58wwmp 2290 10 α α NNP cord-015306-us58wwmp 2290 11 . . . cord-015306-us58wwmp 2291 1 Conclusion conclusion NN cord-015306-us58wwmp 2291 2 : : : cord-015306-us58wwmp 2292 1 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2292 2 might may MD cord-015306-us58wwmp 2292 3 participate participate VB cord-015306-us58wwmp 2292 4 in in IN cord-015306-us58wwmp 2292 5 the the DT cord-015306-us58wwmp 2292 6 proceeding proceeding NN cord-015306-us58wwmp 2292 7 of of IN cord-015306-us58wwmp 2292 8 renal renal JJ cord-015306-us58wwmp 2292 9 IRI IRI NNP cord-015306-us58wwmp 2292 10 by by IN cord-015306-us58wwmp 2292 11 regulation regulation NN cord-015306-us58wwmp 2292 12 on on IN cord-015306-us58wwmp 2292 13 various various JJ cord-015306-us58wwmp 2292 14 CD4 CD4 NNP cord-015306-us58wwmp 2292 15 + + CC cord-015306-us58wwmp 2292 16 T t NN cord-015306-us58wwmp 2292 17 cell cell NN cord-015306-us58wwmp 2292 18 subsets subset NNS cord-015306-us58wwmp 2292 19 . . . cord-015306-us58wwmp 2293 1 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2293 2 might may MD cord-015306-us58wwmp 2293 3 be be VB cord-015306-us58wwmp 2293 4 a a DT cord-015306-us58wwmp 2293 5 potential potential JJ cord-015306-us58wwmp 2293 6 new new JJ cord-015306-us58wwmp 2293 7 marker marker NN cord-015306-us58wwmp 2293 8 for for IN cord-015306-us58wwmp 2293 9 assessing assess VBG cord-015306-us58wwmp 2293 10 severity severity NN cord-015306-us58wwmp 2293 11 of of IN cord-015306-us58wwmp 2293 12 renal renal JJ cord-015306-us58wwmp 2293 13 IRI IRI NNP cord-015306-us58wwmp 2293 14 . . . cord-015306-us58wwmp 2294 1 Expression expression NN cord-015306-us58wwmp 2294 2 of of IN cord-015306-us58wwmp 2294 3 Galectin-9 Galectin-9 NNP cord-015306-us58wwmp 2294 4 and and CC cord-015306-us58wwmp 2295 1 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2295 2 in in IN cord-015306-us58wwmp 2295 3 kidney kidney NN cord-015306-us58wwmp 2295 4 of of IN cord-015306-us58wwmp 2295 5 mice mouse NNS cord-015306-us58wwmp 2295 6 with with IN cord-015306-us58wwmp 2295 7 renal renal JJ cord-015306-us58wwmp 2295 8 ischemia ischemia NN cord-015306-us58wwmp 2295 9 reperfusion reperfusion NN cord-015306-us58wwmp 2295 10 injury injury NN cord-015306-us58wwmp 2295 11 Objective Objective NNP cord-015306-us58wwmp 2295 12 : : : cord-015306-us58wwmp 2295 13 T t NN cord-015306-us58wwmp 2295 14 cell cell NN cord-015306-us58wwmp 2295 15 immunoglobulin-3 immunoglobulin-3 NN cord-015306-us58wwmp 2296 1 ( ( -LRB- cord-015306-us58wwmp 2296 2 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2296 3 ) ) -RRB- cord-015306-us58wwmp 2296 4 is be VBZ cord-015306-us58wwmp 2296 5 a a DT cord-015306-us58wwmp 2296 6 surface surface NN cord-015306-us58wwmp 2296 7 molecule molecule NN cord-015306-us58wwmp 2296 8 expressed express VBN cord-015306-us58wwmp 2296 9 on on IN cord-015306-us58wwmp 2296 10 various various JJ cord-015306-us58wwmp 2296 11 immune immune JJ cord-015306-us58wwmp 2296 12 cells cell NNS cord-015306-us58wwmp 2296 13 which which WDT cord-015306-us58wwmp 2296 14 plays play VBZ cord-015306-us58wwmp 2296 15 a a DT cord-015306-us58wwmp 2296 16 central central JJ cord-015306-us58wwmp 2296 17 role role NN cord-015306-us58wwmp 2296 18 in in IN cord-015306-us58wwmp 2296 19 immune immune JJ cord-015306-us58wwmp 2296 20 regulation regulation NN cord-015306-us58wwmp 2296 21 . . . cord-015306-us58wwmp 2297 1 Identification identification NN cord-015306-us58wwmp 2297 2 of of IN cord-015306-us58wwmp 2297 3 galectin-9 galectin-9 NNP cord-015306-us58wwmp 2297 4 ( ( -LRB- cord-015306-us58wwmp 2297 5 Gal-9 Gal-9 NNP cord-015306-us58wwmp 2297 6 ) ) -RRB- cord-015306-us58wwmp 2297 7 as as IN cord-015306-us58wwmp 2297 8 a a DT cord-015306-us58wwmp 2297 9 ligand ligand NN cord-015306-us58wwmp 2297 10 for for IN cord-015306-us58wwmp 2297 11 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2297 12 has have VBZ cord-015306-us58wwmp 2297 13 established establish VBN cord-015306-us58wwmp 2297 14 that that IN cord-015306-us58wwmp 2297 15 the the DT cord-015306-us58wwmp 2297 16 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2297 17 / / SYM cord-015306-us58wwmp 2297 18 Gal-9 Gal-9 NNP cord-015306-us58wwmp 2297 19 pathway pathway NN cord-015306-us58wwmp 2297 20 has have VBZ cord-015306-us58wwmp 2297 21 been be VBN cord-015306-us58wwmp 2297 22 linked link VBN cord-015306-us58wwmp 2297 23 to to IN cord-015306-us58wwmp 2297 24 several several JJ cord-015306-us58wwmp 2297 25 inflammatory inflammatory JJ cord-015306-us58wwmp 2297 26 diseases disease NNS cord-015306-us58wwmp 2297 27 by by IN cord-015306-us58wwmp 2297 28 regulating regulate VBG cord-015306-us58wwmp 2297 29 adaptive adaptive JJ cord-015306-us58wwmp 2297 30 and and CC cord-015306-us58wwmp 2297 31 innate innate JJ cord-015306-us58wwmp 2297 32 immunity immunity NN cord-015306-us58wwmp 2297 33 . . . cord-015306-us58wwmp 2298 1 To to TO cord-015306-us58wwmp 2298 2 study study VB cord-015306-us58wwmp 2298 3 the the DT cord-015306-us58wwmp 2298 4 expression expression NN cord-015306-us58wwmp 2298 5 of of IN cord-015306-us58wwmp 2299 1 Gal-9 Gal-9 NNP cord-015306-us58wwmp 2299 2 and and CC cord-015306-us58wwmp 2299 3 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2299 4 in in IN cord-015306-us58wwmp 2299 5 kidney kidney NN cord-015306-us58wwmp 2299 6 of of IN cord-015306-us58wwmp 2299 7 mice mouse NNS cord-015306-us58wwmp 2299 8 with with IN cord-015306-us58wwmp 2299 9 renal renal JJ cord-015306-us58wwmp 2299 10 ischemia ischemia NN cord-015306-us58wwmp 2299 11 reperfusion reperfusion NN cord-015306-us58wwmp 2299 12 injury injury NN cord-015306-us58wwmp 2299 13 ( ( -LRB- cord-015306-us58wwmp 2299 14 IRI IRI NNP cord-015306-us58wwmp 2299 15 ) ) -RRB- cord-015306-us58wwmp 2299 16 . . . cord-015306-us58wwmp 2300 1 Methods method NNS cord-015306-us58wwmp 2300 2 : : : cord-015306-us58wwmp 2301 1 Thirty thirty CD cord-015306-us58wwmp 2301 2 C57BL6 c57bl6 NN cord-015306-us58wwmp 2301 3 male male JJ cord-015306-us58wwmp 2301 4 mice mouse NNS cord-015306-us58wwmp 2301 5 were be VBD cord-015306-us58wwmp 2301 6 randomized randomize VBN cord-015306-us58wwmp 2301 7 into into IN cord-015306-us58wwmp 2301 8 renal renal JJ cord-015306-us58wwmp 2301 9 IRI IRI NNP cord-015306-us58wwmp 2301 10 groups group NNS cord-015306-us58wwmp 2301 11 with with IN cord-015306-us58wwmp 2301 12 and and CC cord-015306-us58wwmp 2301 13 without without IN cord-015306-us58wwmp 2301 14 recombinant recombinant JJ cord-015306-us58wwmp 2301 15 Gal-9 Gal-9 NNP cord-015306-us58wwmp 2301 16 . . . cord-015306-us58wwmp 2302 1 The the DT cord-015306-us58wwmp 2302 2 left left JJ cord-015306-us58wwmp 2302 3 renal renal JJ cord-015306-us58wwmp 2302 4 pedicle pedicle NN cord-015306-us58wwmp 2302 5 was be VBD cord-015306-us58wwmp 2302 6 clamped clamp VBN cord-015306-us58wwmp 2302 7 in in IN cord-015306-us58wwmp 2302 8 C57BL6 C57BL6 NNP cord-015306-us58wwmp 2302 9 mice mouse NNS cord-015306-us58wwmp 2302 10 for for IN cord-015306-us58wwmp 2302 11 45 45 CD cord-015306-us58wwmp 2302 12 min min NN cord-015306-us58wwmp 2302 13 , , , cord-015306-us58wwmp 2302 14 followed follow VBN cord-015306-us58wwmp 2302 15 by by IN cord-015306-us58wwmp 2302 16 reperfusion reperfusion NN cord-015306-us58wwmp 2302 17 . . . cord-015306-us58wwmp 2303 1 Animals animal NNS cord-015306-us58wwmp 2303 2 were be VBD cord-015306-us58wwmp 2303 3 sacrificed sacrifice VBN cord-015306-us58wwmp 2303 4 at at IN cord-015306-us58wwmp 2303 5 baseline baseline NN cord-015306-us58wwmp 2303 6 , , , cord-015306-us58wwmp 2303 7 day day NN cord-015306-us58wwmp 2303 8 1,3,10 1,3,10 CD cord-015306-us58wwmp 2303 9 , , , cord-015306-us58wwmp 2303 10 21 21 CD cord-015306-us58wwmp 2303 11 after after IN cord-015306-us58wwmp 2303 12 IRI IRI NNP cord-015306-us58wwmp 2303 13 . . . cord-015306-us58wwmp 2304 1 Gal-9 Gal-9 NNP cord-015306-us58wwmp 2304 2 and and CC cord-015306-us58wwmp 2304 3 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2304 4 mRNA mRNA NNP cord-015306-us58wwmp 2304 5 levels level NNS cord-015306-us58wwmp 2304 6 in in IN cord-015306-us58wwmp 2304 7 kidney kidney NN cord-015306-us58wwmp 2304 8 tissues tissue NNS cord-015306-us58wwmp 2304 9 were be VBD cord-015306-us58wwmp 2304 10 determined determine VBN cord-015306-us58wwmp 2304 11 using use VBG cord-015306-us58wwmp 2304 12 real real JJ cord-015306-us58wwmp 2304 13 - - HYPH cord-015306-us58wwmp 2304 14 time time NN cord-015306-us58wwmp 2304 15 RT RT NNP cord-015306-us58wwmp 2304 16 - - HYPH cord-015306-us58wwmp 2304 17 PCR PCR NNP cord-015306-us58wwmp 2304 18 . . . cord-015306-us58wwmp 2305 1 Expression expression NN cord-015306-us58wwmp 2305 2 of of IN cord-015306-us58wwmp 2306 1 Gal-9 Gal-9 NNP cord-015306-us58wwmp 2306 2 in in IN cord-015306-us58wwmp 2306 3 kidney kidney NN cord-015306-us58wwmp 2306 4 were be VBD cord-015306-us58wwmp 2306 5 detected detect VBN cord-015306-us58wwmp 2306 6 by by IN cord-015306-us58wwmp 2306 7 immunohistochemistry immunohistochemistry NN cord-015306-us58wwmp 2306 8 staining staining NN cord-015306-us58wwmp 2306 9 .The .The . cord-015306-us58wwmp 2306 10 levels level NNS cord-015306-us58wwmp 2306 11 of of IN cord-015306-us58wwmp 2306 12 TNF TNF NNP cord-015306-us58wwmp 2306 13 - - HYPH cord-015306-us58wwmp 2306 14 α α NNP cord-015306-us58wwmp 2306 15 , , , cord-015306-us58wwmp 2306 16 IFN IFN NNP cord-015306-us58wwmp 2306 17 - - HYPH cord-015306-us58wwmp 2306 18 γ γ NNP cord-015306-us58wwmp 2306 19 , , , cord-015306-us58wwmp 2306 20 IL-4 IL-4 NNP cord-015306-us58wwmp 2306 21 and and CC cord-015306-us58wwmp 2306 22 IL-10 IL-10 NNP cord-015306-us58wwmp 2306 23 in in IN cord-015306-us58wwmp 2306 24 kidney kidney NN cord-015306-us58wwmp 2306 25 tissue tissue NN cord-015306-us58wwmp 2306 26 were be VBD cord-015306-us58wwmp 2306 27 measured measure VBN cord-015306-us58wwmp 2306 28 using use VBG cord-015306-us58wwmp 2306 29 ELISA ELISA NNP cord-015306-us58wwmp 2306 30 . . . cord-015306-us58wwmp 2307 1 Results result NNS cord-015306-us58wwmp 2307 2 : : : cord-015306-us58wwmp 2308 1 The the DT cord-015306-us58wwmp 2308 2 expression expression NN cord-015306-us58wwmp 2308 3 of of IN cord-015306-us58wwmp 2309 1 Gal-9 Gal-9 NNP cord-015306-us58wwmp 2309 2 and and CC cord-015306-us58wwmp 2309 3 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2309 4 mRNA mrna NN cord-015306-us58wwmp 2309 5 in in IN cord-015306-us58wwmp 2309 6 the the DT cord-015306-us58wwmp 2309 7 injured injure VBN cord-015306-us58wwmp 2309 8 kidney kidney NN cord-015306-us58wwmp 2309 9 tissues tissue NNS cord-015306-us58wwmp 2309 10 increased increase VBD cord-015306-us58wwmp 2309 11 significantly significantly RB cord-015306-us58wwmp 2309 12 compared compare VBN cord-015306-us58wwmp 2309 13 with with IN cord-015306-us58wwmp 2309 14 uninjured uninjured JJ cord-015306-us58wwmp 2309 15 kidney kidney NN cord-015306-us58wwmp 2309 16 tissues tissue NNS cord-015306-us58wwmp 2309 17 and and CC cord-015306-us58wwmp 2309 18 baseline baseline JJ cord-015306-us58wwmp 2309 19 ( ( -LRB- cord-015306-us58wwmp 2309 20 P<0 P<0 NNP cord-015306-us58wwmp 2309 21 . . . cord-015306-us58wwmp 2309 22 05 05 CD cord-015306-us58wwmp 2309 23 ) ) -RRB- cord-015306-us58wwmp 2309 24 . . . cord-015306-us58wwmp 2310 1 Compared compare VBN cord-015306-us58wwmp 2310 2 with with IN cord-015306-us58wwmp 2310 3 the the DT cord-015306-us58wwmp 2310 4 uninjured uninjured JJ cord-015306-us58wwmp 2310 5 control control NN cord-015306-us58wwmp 2310 6 and and CC cord-015306-us58wwmp 2310 7 baseline baseline JJ cord-015306-us58wwmp 2310 8 control control NN cord-015306-us58wwmp 2310 9 , , , cord-015306-us58wwmp 2310 10 the the DT cord-015306-us58wwmp 2310 11 expression expression NN cord-015306-us58wwmp 2310 12 of of IN cord-015306-us58wwmp 2310 13 TNF TNF NNP cord-015306-us58wwmp 2310 14 - - HYPH cord-015306-us58wwmp 2310 15 α α NNP cord-015306-us58wwmp 2310 16 and and CC cord-015306-us58wwmp 2310 17 IFN IFN NNP cord-015306-us58wwmp 2310 18 - - HYPH cord-015306-us58wwmp 2310 19 γ γ NNP cord-015306-us58wwmp 2310 20 increased increase VBD cord-015306-us58wwmp 2310 21 significantly significantly RB cord-015306-us58wwmp 2310 22 in in IN cord-015306-us58wwmp 2310 23 the the DT cord-015306-us58wwmp 2310 24 injured injure VBN cord-015306-us58wwmp 2310 25 kidney kidney NN cord-015306-us58wwmp 2310 26 . . . cord-015306-us58wwmp 2311 1 The the DT cord-015306-us58wwmp 2311 2 expression expression NN cord-015306-us58wwmp 2311 3 of of IN cord-015306-us58wwmp 2312 1 Gal-9 Gal-9 NNP cord-015306-us58wwmp 2312 2 and and CC cord-015306-us58wwmp 2312 3 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2312 4 mRNA mRNA NNP cord-015306-us58wwmp 2312 5 was be VBD cord-015306-us58wwmp 2312 6 positively positively RB cord-015306-us58wwmp 2312 7 correlated correlate VBN cord-015306-us58wwmp 2312 8 with with IN cord-015306-us58wwmp 2312 9 renal renal JJ cord-015306-us58wwmp 2312 10 IL-4 IL-4 NNP cord-015306-us58wwmp 2312 11 and and CC cord-015306-us58wwmp 2312 12 IL-10 IL-10 NNP cord-015306-us58wwmp 2312 13 level level NN cord-015306-us58wwmp 2312 14 ( ( -LRB- cord-015306-us58wwmp 2312 15 r=0.792 r=0.792 JJ cord-015306-us58wwmp 2312 16 , , , cord-015306-us58wwmp 2312 17 r=0.79 r=0.79 VB cord-015306-us58wwmp 2312 18 respectively respectively RB cord-015306-us58wwmp 2312 19 ; ; : cord-015306-us58wwmp 2312 20 P<0 P<0 NNP cord-015306-us58wwmp 2312 21 . . . cord-015306-us58wwmp 2312 22 05 05 CD cord-015306-us58wwmp 2312 23 ) ) -RRB- cord-015306-us58wwmp 2312 24 , , , cord-015306-us58wwmp 2312 25 but but CC cord-015306-us58wwmp 2312 26 negatively negatively RB cord-015306-us58wwmp 2312 27 correlated correlate VBN cord-015306-us58wwmp 2312 28 with with IN cord-015306-us58wwmp 2312 29 kidney kidney NN cord-015306-us58wwmp 2312 30 TNF TNF NNP cord-015306-us58wwmp 2312 31 - - HYPH cord-015306-us58wwmp 2312 32 α α NNP cord-015306-us58wwmp 2312 33 and and CC cord-015306-us58wwmp 2312 34 IFN IFN NNP cord-015306-us58wwmp 2312 35 - - HYPH cord-015306-us58wwmp 2312 36 γ γ NN cord-015306-us58wwmp 2312 37 level level NN cord-015306-us58wwmp 2312 38 ( ( -LRB- cord-015306-us58wwmp 2312 39 r=-0.69,r=-0.75 r=-0.69,r=-0.75 NNP cord-015306-us58wwmp 2312 40 respectively respectively RB cord-015306-us58wwmp 2312 41 , , , cord-015306-us58wwmp 2312 42 P<0.05 P<0.05 NNS cord-015306-us58wwmp 2312 43 ) ) -RRB- cord-015306-us58wwmp 2312 44 . . . cord-015306-us58wwmp 2313 1 After after IN cord-015306-us58wwmp 2313 2 recombinant recombinant JJ cord-015306-us58wwmp 2313 3 Gal-9 Gal-9 NNP cord-015306-us58wwmp 2313 4 treatment treatment NN cord-015306-us58wwmp 2313 5 for for IN cord-015306-us58wwmp 2313 6 three three CD cord-015306-us58wwmp 2313 7 days day NNS cord-015306-us58wwmp 2313 8 , , , cord-015306-us58wwmp 2313 9 the the DT cord-015306-us58wwmp 2313 10 kidney kidney NN cord-015306-us58wwmp 2313 11 injury injury NN cord-015306-us58wwmp 2313 12 ameliorated ameliorate VBD cord-015306-us58wwmp 2313 13 and and CC cord-015306-us58wwmp 2313 14 inflammatory inflammatory JJ cord-015306-us58wwmp 2313 15 cytokines cytokine NNS cord-015306-us58wwmp 2313 16 ( ( -LRB- cord-015306-us58wwmp 2313 17 TNF TNF NNP cord-015306-us58wwmp 2313 18 - - HYPH cord-015306-us58wwmp 2313 19 α α NNP cord-015306-us58wwmp 2313 20 and and CC cord-015306-us58wwmp 2313 21 IFN IFN NNP cord-015306-us58wwmp 2313 22 - - HYPH cord-015306-us58wwmp 2313 23 γ γ NNP cord-015306-us58wwmp 2313 24 ) ) -RRB- cord-015306-us58wwmp 2313 25 decreased decrease VBD cord-015306-us58wwmp 2313 26 . . . cord-015306-us58wwmp 2314 1 The the DT cord-015306-us58wwmp 2314 2 expression expression NN cord-015306-us58wwmp 2314 3 of of IN cord-015306-us58wwmp 2314 4 Gal-9 Gal-9 NNP cord-015306-us58wwmp 2314 5 and and CC cord-015306-us58wwmp 2314 6 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2314 7 in in IN cord-015306-us58wwmp 2314 8 kidney kidney NN cord-015306-us58wwmp 2314 9 tissues tissue NNS cord-015306-us58wwmp 2314 10 increase increase VB cord-015306-us58wwmp 2314 11 in in IN cord-015306-us58wwmp 2314 12 mice mouse NNS cord-015306-us58wwmp 2314 13 with with IN cord-015306-us58wwmp 2314 14 kidney kidney NN cord-015306-us58wwmp 2314 15 IRI IRI NNP cord-015306-us58wwmp 2314 16 . . . cord-015306-us58wwmp 2315 1 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2315 2 / / SYM cord-015306-us58wwmp 2315 3 Gal-9 Gal-9 NNP cord-015306-us58wwmp 2315 4 pathway pathway NN cord-015306-us58wwmp 2315 5 are be VBP cord-015306-us58wwmp 2315 6 closely closely RB cord-015306-us58wwmp 2315 7 related relate VBN cord-015306-us58wwmp 2315 8 to to IN cord-015306-us58wwmp 2315 9 inflammatory inflammatory JJ cord-015306-us58wwmp 2315 10 process process NN cord-015306-us58wwmp 2315 11 in in IN cord-015306-us58wwmp 2315 12 renal renal JJ cord-015306-us58wwmp 2315 13 IRI IRI NNP cord-015306-us58wwmp 2315 14 . . . cord-015306-us58wwmp 2316 1 Objective objective JJ cord-015306-us58wwmp 2316 2 : : : cord-015306-us58wwmp 2316 3 We -PRON- PRP cord-015306-us58wwmp 2316 4 previously previously RB cord-015306-us58wwmp 2316 5 found find VBD cord-015306-us58wwmp 2316 6 that that IN cord-015306-us58wwmp 2316 7 RGC-32(Response RGC-32(Response NNP cord-015306-us58wwmp 2316 8 Gene Gene NNP cord-015306-us58wwmp 2316 9 to to IN cord-015306-us58wwmp 2316 10 Complement-32 Complement-32 NNP cord-015306-us58wwmp 2316 11 ) ) -RRB- cord-015306-us58wwmp 2316 12 , , , cord-015306-us58wwmp 2316 13 a a DT cord-015306-us58wwmp 2316 14 key key JJ cord-015306-us58wwmp 2316 15 factor factor NN cord-015306-us58wwmp 2316 16 in in IN cord-015306-us58wwmp 2316 17 regulating regulate VBG cord-015306-us58wwmp 2316 18 cell cell NN cord-015306-us58wwmp 2316 19 cycle cycle NN cord-015306-us58wwmp 2316 20 , , , cord-015306-us58wwmp 2316 21 plays play VBZ cord-015306-us58wwmp 2316 22 an an DT cord-015306-us58wwmp 2316 23 important important JJ cord-015306-us58wwmp 2316 24 role role NN cord-015306-us58wwmp 2316 25 in in IN cord-015306-us58wwmp 2316 26 dealing deal VBG cord-015306-us58wwmp 2316 27 with with IN cord-015306-us58wwmp 2316 28 epithelial epithelial NN cord-015306-us58wwmp 2316 29 - - HYPH cord-015306-us58wwmp 2316 30 mesenchymal mesenchymal JJ cord-015306-us58wwmp 2316 31 transition transition NN cord-015306-us58wwmp 2316 32 ( ( -LRB- cord-015306-us58wwmp 2316 33 EMT EMT NNP cord-015306-us58wwmp 2316 34 ) ) -RRB- cord-015306-us58wwmp 2316 35 . . . cord-015306-us58wwmp 2317 1 This this DT cord-015306-us58wwmp 2317 2 study study NN cord-015306-us58wwmp 2317 3 aimed aim VBD cord-015306-us58wwmp 2317 4 to to TO cord-015306-us58wwmp 2317 5 evaluate evaluate VB cord-015306-us58wwmp 2317 6 the the DT cord-015306-us58wwmp 2317 7 effects effect NNS cord-015306-us58wwmp 2317 8 of of IN cord-015306-us58wwmp 2317 9 RGC-32 RGC-32 NNP cord-015306-us58wwmp 2317 10 regulating regulating NN cord-015306-us58wwmp 2317 11 cell cell NN cord-015306-us58wwmp 2317 12 cycle cycle NN cord-015306-us58wwmp 2317 13 in in IN cord-015306-us58wwmp 2317 14 renal renal JJ cord-015306-us58wwmp 2317 15 tubular tubular JJ cord-015306-us58wwmp 2317 16 epithelial epithelial JJ cord-015306-us58wwmp 2317 17 cells cell NNS cord-015306-us58wwmp 2317 18 injury injury NN cord-015306-us58wwmp 2317 19 and and CC cord-015306-us58wwmp 2317 20 repair repair NN cord-015306-us58wwmp 2317 21 . . . cord-015306-us58wwmp 2318 1 Methods method NNS cord-015306-us58wwmp 2318 2 : : : cord-015306-us58wwmp 2319 1 ( ( -LRB- cord-015306-us58wwmp 2319 2 1 1 LS cord-015306-us58wwmp 2319 3 ) ) -RRB- cord-015306-us58wwmp 2319 4 Objective objective NN cord-015306-us58wwmp 2319 5 : : : cord-015306-us58wwmp 2319 6 Autophagy Autophagy NNP cord-015306-us58wwmp 2319 7 is be VBZ cord-015306-us58wwmp 2319 8 a a DT cord-015306-us58wwmp 2319 9 lysosomal lysosomal JJ cord-015306-us58wwmp 2319 10 degradation degradation NN cord-015306-us58wwmp 2319 11 pathway pathway NN cord-015306-us58wwmp 2319 12 that that WDT cord-015306-us58wwmp 2319 13 is be VBZ cord-015306-us58wwmp 2319 14 essential essential JJ cord-015306-us58wwmp 2319 15 for for IN cord-015306-us58wwmp 2319 16 cellular cellular JJ cord-015306-us58wwmp 2319 17 stress stress NN cord-015306-us58wwmp 2319 18 adaptation adaptation NN cord-015306-us58wwmp 2319 19 and and CC cord-015306-us58wwmp 2319 20 normal normal JJ cord-015306-us58wwmp 2319 21 homeostasis homeostasis NN cord-015306-us58wwmp 2319 22 . . . cord-015306-us58wwmp 2320 1 Increased increase VBN cord-015306-us58wwmp 2320 2 level level NN cord-015306-us58wwmp 2320 3 of of IN cord-015306-us58wwmp 2320 4 autophagy autophagy NN cord-015306-us58wwmp 2320 5 has have VBZ cord-015306-us58wwmp 2320 6 been be VBN cord-015306-us58wwmp 2320 7 reported report VBN cord-015306-us58wwmp 2320 8 in in IN cord-015306-us58wwmp 2320 9 the the DT cord-015306-us58wwmp 2320 10 post post JJ cord-015306-us58wwmp 2320 11 - - JJ cord-015306-us58wwmp 2320 12 ischemic ischemic JJ cord-015306-us58wwmp 2320 13 kidneys kidney NNS cord-015306-us58wwmp 2320 14 by by IN cord-015306-us58wwmp 2320 15 static static JJ cord-015306-us58wwmp 2320 16 analysis analysis NN cord-015306-us58wwmp 2320 17 . . . cord-015306-us58wwmp 2321 1 This this DT cord-015306-us58wwmp 2321 2 study study NN cord-015306-us58wwmp 2321 3 aimed aim VBD cord-015306-us58wwmp 2321 4 to to TO cord-015306-us58wwmp 2321 5 understand understand VB cord-015306-us58wwmp 2321 6 the the DT cord-015306-us58wwmp 2321 7 dynamics dynamic NNS cord-015306-us58wwmp 2321 8 of of IN cord-015306-us58wwmp 2321 9 epithelial epithelial JJ cord-015306-us58wwmp 2321 10 autophagy autophagy NN cord-015306-us58wwmp 2321 11 in in IN cord-015306-us58wwmp 2321 12 kidneys kidney NNS cord-015306-us58wwmp 2321 13 following follow VBG cord-015306-us58wwmp 2321 14 acute acute JJ cord-015306-us58wwmp 2321 15 ischemic ischemic JJ cord-015306-us58wwmp 2321 16 injury injury NN cord-015306-us58wwmp 2321 17 and and CC cord-015306-us58wwmp 2321 18 during during IN cord-015306-us58wwmp 2321 19 renal renal JJ cord-015306-us58wwmp 2321 20 repair repair NN cord-015306-us58wwmp 2321 21 . . . cord-015306-us58wwmp 2322 1 Methods method NNS cord-015306-us58wwmp 2322 2 : : : cord-015306-us58wwmp 2322 3 Taking take VBG cord-015306-us58wwmp 2322 4 the the DT cord-015306-us58wwmp 2322 5 advantage advantage NN cord-015306-us58wwmp 2322 6 of of IN cord-015306-us58wwmp 2322 7 differential differential JJ cord-015306-us58wwmp 2322 8 pH ph NN cord-015306-us58wwmp 2322 9 sensitivity sensitivity NN cord-015306-us58wwmp 2322 10 of of IN cord-015306-us58wwmp 2322 11 RFP RFP NNP cord-015306-us58wwmp 2322 12 ( ( -LRB- cord-015306-us58wwmp 2322 13 pKa pKa NNP cord-015306-us58wwmp 2322 14 4.5 4.5 CD cord-015306-us58wwmp 2322 15 ) ) -RRB- cord-015306-us58wwmp 2322 16 and and CC cord-015306-us58wwmp 2322 17 EGFP EGFP NNP cord-015306-us58wwmp 2322 18 ( ( -LRB- cord-015306-us58wwmp 2322 19 pKa pKa NNP cord-015306-us58wwmp 2322 20 5.9 5.9 CD cord-015306-us58wwmp 2322 21 ) ) -RRB- cord-015306-us58wwmp 2322 22 fluorescence fluorescence NN cord-015306-us58wwmp 2322 23 , , , cord-015306-us58wwmp 2322 24 we -PRON- PRP cord-015306-us58wwmp 2322 25 generated generate VBD cord-015306-us58wwmp 2322 26 a a DT cord-015306-us58wwmp 2322 27 new new JJ cord-015306-us58wwmp 2322 28 strain strain NN cord-015306-us58wwmp 2322 29 of of IN cord-015306-us58wwmp 2322 30 CAG CAG NNP cord-015306-us58wwmp 2322 31 - - HYPH cord-015306-us58wwmp 2322 32 RFP RFP NNP cord-015306-us58wwmp 2322 33 - - HYPH cord-015306-us58wwmp 2322 34 EGFP EGFP NNP cord-015306-us58wwmp 2322 35 - - HYPH cord-015306-us58wwmp 2322 36 LC3 lc3 JJ cord-015306-us58wwmp 2322 37 mice mouse NNS cord-015306-us58wwmp 2322 38 to to TO cord-015306-us58wwmp 2322 39 distinguish distinguish VB cord-015306-us58wwmp 2322 40 early early JJ cord-015306-us58wwmp 2322 41 autophagic autophagic JJ cord-015306-us58wwmp 2322 42 vacuoles vacuole NNS cord-015306-us58wwmp 2322 43 from from IN cord-015306-us58wwmp 2322 44 autolysosomes autolysosome NNS cord-015306-us58wwmp 2322 45 and and CC cord-015306-us58wwmp 2322 46 to to TO cord-015306-us58wwmp 2322 47 monitor monitor VB cord-015306-us58wwmp 2322 48 autophagic autophagic JJ cord-015306-us58wwmp 2322 49 process process NN cord-015306-us58wwmp 2322 50 in in IN cord-015306-us58wwmp 2322 51 the the DT cord-015306-us58wwmp 2322 52 kidneys kidney NNS cord-015306-us58wwmp 2322 53 with with IN cord-015306-us58wwmp 2322 54 ischemia ischemia NN cord-015306-us58wwmp 2322 55 - - HYPH cord-015306-us58wwmp 2322 56 reperfusion reperfusion NN cord-015306-us58wwmp 2322 57 injury injury NN cord-015306-us58wwmp 2322 58 ( ( -LRB- cord-015306-us58wwmp 2322 59 IRI IRI NNP cord-015306-us58wwmp 2322 60 ) ) -RRB- cord-015306-us58wwmp 2322 61 . . . cord-015306-us58wwmp 2323 1 Results result NNS cord-015306-us58wwmp 2323 2 : : : cord-015306-us58wwmp 2324 1 Renal renal JJ cord-015306-us58wwmp 2324 2 epithelial epithelial JJ cord-015306-us58wwmp 2324 3 cells cell NNS cord-015306-us58wwmp 2324 4 responded respond VBD cord-015306-us58wwmp 2324 5 to to IN cord-015306-us58wwmp 2324 6 nutrient nutrient NN cord-015306-us58wwmp 2324 7 deprivation deprivation NN cord-015306-us58wwmp 2324 8 with with IN cord-015306-us58wwmp 2324 9 easily easily RB cord-015306-us58wwmp 2324 10 detectable detectable JJ cord-015306-us58wwmp 2324 11 fluorescent fluorescent JJ cord-015306-us58wwmp 2324 12 puncta puncta NN cord-015306-us58wwmp 2324 13 that that WDT cord-015306-us58wwmp 2324 14 represented represent VBD cord-015306-us58wwmp 2324 15 autophagic autophagic JJ cord-015306-us58wwmp 2324 16 vacuoles vacuole NNS cord-015306-us58wwmp 2324 17 and and CC cord-015306-us58wwmp 2324 18 corresponded correspond VBD cord-015306-us58wwmp 2324 19 to to IN cord-015306-us58wwmp 2324 20 LC3-II lc3-ii NN cord-015306-us58wwmp 2324 21 and and CC cord-015306-us58wwmp 2324 22 Atg5 atg5 JJ cord-015306-us58wwmp 2324 23 protein protein NN cord-015306-us58wwmp 2324 24 levels level NNS cord-015306-us58wwmp 2324 25 . . . cord-015306-us58wwmp 2325 1 The the DT cord-015306-us58wwmp 2325 2 majority majority NN cord-015306-us58wwmp 2325 3 of of IN cord-015306-us58wwmp 2325 4 the the DT cord-015306-us58wwmp 2325 5 EGFP EGFP NNP cord-015306-us58wwmp 2325 6 lost lose VBD cord-015306-us58wwmp 2325 7 its -PRON- PRP$ cord-015306-us58wwmp 2325 8 fluorescence fluorescence NN cord-015306-us58wwmp 2325 9 in in IN cord-015306-us58wwmp 2325 10 the the DT cord-015306-us58wwmp 2325 11 acidic acidic JJ cord-015306-us58wwmp 2325 12 environment environment NN cord-015306-us58wwmp 2325 13 of of IN cord-015306-us58wwmp 2325 14 the the DT cord-015306-us58wwmp 2325 15 autolysosomes autolysosome NNS cord-015306-us58wwmp 2325 16 where where WRB cord-015306-us58wwmp 2325 17 bright bright JJ cord-015306-us58wwmp 2325 18 RFP RFP NNP cord-015306-us58wwmp 2325 19 signals signal NNS cord-015306-us58wwmp 2325 20 remained remain VBD cord-015306-us58wwmp 2325 21 . . . cord-015306-us58wwmp 2326 1 In in IN cord-015306-us58wwmp 2326 2 normal normal JJ cord-015306-us58wwmp 2326 3 kidneys kidney NNS cord-015306-us58wwmp 2326 4 , , , cord-015306-us58wwmp 2326 5 few few JJ cord-015306-us58wwmp 2326 6 EGFP EGFP NNP cord-015306-us58wwmp 2326 7 and and CC cord-015306-us58wwmp 2326 8 RFP RFP NNP cord-015306-us58wwmp 2326 9 puncta puncta NN cord-015306-us58wwmp 2326 10 were be VBD cord-015306-us58wwmp 2326 11 present present JJ cord-015306-us58wwmp 2326 12 in in IN cord-015306-us58wwmp 2326 13 the the DT cord-015306-us58wwmp 2326 14 nephron nephron NN cord-015306-us58wwmp 2326 15 . . . cord-015306-us58wwmp 2327 1 IRI IRI NNP cord-015306-us58wwmp 2327 2 led lead VBD cord-015306-us58wwmp 2327 3 to to IN cord-015306-us58wwmp 2327 4 dynamic dynamic JJ cord-015306-us58wwmp 2327 5 changes change NNS cord-015306-us58wwmp 2327 6 in in IN cord-015306-us58wwmp 2327 7 autophagic autophagic JJ cord-015306-us58wwmp 2327 8 process process NN cord-015306-us58wwmp 2327 9 in in IN cord-015306-us58wwmp 2327 10 the the DT cord-015306-us58wwmp 2327 11 proximal proximal JJ cord-015306-us58wwmp 2327 12 tubules tubule NNS cord-015306-us58wwmp 2327 13 with with IN cord-015306-us58wwmp 2327 14 the the DT cord-015306-us58wwmp 2327 15 number number NN cord-015306-us58wwmp 2327 16 of of IN cord-015306-us58wwmp 2327 17 EGFP EGFP NNP cord-015306-us58wwmp 2327 18 puncta puncta NN cord-015306-us58wwmp 2327 19 reaching reach VBG cord-015306-us58wwmp 2327 20 the the DT cord-015306-us58wwmp 2327 21 peak peak NN cord-015306-us58wwmp 2327 22 at at IN cord-015306-us58wwmp 2327 23 1 1 CD cord-015306-us58wwmp 2327 24 day day NN cord-015306-us58wwmp 2327 25 and and CC cord-015306-us58wwmp 2327 26 returning return VBG cord-015306-us58wwmp 2327 27 to to IN cord-015306-us58wwmp 2327 28 the the DT cord-015306-us58wwmp 2327 29 control control NN cord-015306-us58wwmp 2327 30 level level NN cord-015306-us58wwmp 2327 31 at at IN cord-015306-us58wwmp 2327 32 3 3 CD cord-015306-us58wwmp 2327 33 days day NNS cord-015306-us58wwmp 2327 34 whereas whereas IN cord-015306-us58wwmp 2327 35 RFP RFP NNP cord-015306-us58wwmp 2327 36 puncta puncta NN cord-015306-us58wwmp 2327 37 persisted persist VBD cord-015306-us58wwmp 2327 38 at at IN cord-015306-us58wwmp 2327 39 a a DT cord-015306-us58wwmp 2327 40 high high JJ cord-015306-us58wwmp 2327 41 level level NN cord-015306-us58wwmp 2327 42 through through IN cord-015306-us58wwmp 2327 43 3 3 CD cord-015306-us58wwmp 2327 44 days day NNS cord-015306-us58wwmp 2327 45 post post NN cord-015306-us58wwmp 2327 46 injury injury NN cord-015306-us58wwmp 2327 47 , , , cord-015306-us58wwmp 2327 48 indicating indicate VBG cord-015306-us58wwmp 2327 49 autophagy autophagy NN cord-015306-us58wwmp 2327 50 initiation initiation NN cord-015306-us58wwmp 2327 51 at at IN cord-015306-us58wwmp 2327 52 1 1 CD cord-015306-us58wwmp 2327 53 day day NN cord-015306-us58wwmp 2327 54 but but CC cord-015306-us58wwmp 2327 55 autophagosome autophagosome JJ cord-015306-us58wwmp 2327 56 clearance clearance NN cord-015306-us58wwmp 2327 57 at at IN cord-015306-us58wwmp 2327 58 3 3 CD cord-015306-us58wwmp 2327 59 days day NNS cord-015306-us58wwmp 2327 60 as as IN cord-015306-us58wwmp 2327 61 kidneys kidney NNS cord-015306-us58wwmp 2327 62 were be VBD cord-015306-us58wwmp 2327 63 recovering recover VBG cord-015306-us58wwmp 2327 64 . . . cord-015306-us58wwmp 2328 1 Since since IN cord-015306-us58wwmp 2328 2 RFP RFP NNP cord-015306-us58wwmp 2328 3 puncta puncta NN cord-015306-us58wwmp 2328 4 persisted persist VBD cord-015306-us58wwmp 2328 5 in in IN cord-015306-us58wwmp 2328 6 cells cell NNS cord-015306-us58wwmp 2328 7 with with IN cord-015306-us58wwmp 2328 8 recent recent JJ cord-015306-us58wwmp 2328 9 autophagy autophagy NN cord-015306-us58wwmp 2328 10 , , , cord-015306-us58wwmp 2328 11 we -PRON- PRP cord-015306-us58wwmp 2328 12 examined examine VBD cord-015306-us58wwmp 2328 13 Ki67 Ki67 NNP cord-015306-us58wwmp 2328 14 expression expression NN cord-015306-us58wwmp 2328 15 and and CC cord-015306-us58wwmp 2328 16 found find VBD cord-015306-us58wwmp 2328 17 significantly significantly RB cord-015306-us58wwmp 2328 18 lower low JJR cord-015306-us58wwmp 2328 19 proliferation proliferation NN cord-015306-us58wwmp 2328 20 in in IN cord-015306-us58wwmp 2328 21 cells cell NNS cord-015306-us58wwmp 2328 22 that that WDT cord-015306-us58wwmp 2328 23 contained contain VBD cord-015306-us58wwmp 2328 24 RFP RFP NNP cord-015306-us58wwmp 2328 25 puncta puncta NN cord-015306-us58wwmp 2328 26 , , , cord-015306-us58wwmp 2328 27 suggesting suggest VBG cord-015306-us58wwmp 2328 28 that that IN cord-015306-us58wwmp 2328 29 autophagic autophagic NNP cord-015306-us58wwmp 2328 30 cells cell NNS cord-015306-us58wwmp 2328 31 were be VBD cord-015306-us58wwmp 2328 32 less less RBR cord-015306-us58wwmp 2328 33 likely likely JJ cord-015306-us58wwmp 2328 34 to to TO cord-015306-us58wwmp 2328 35 divide divide VB cord-015306-us58wwmp 2328 36 for for IN cord-015306-us58wwmp 2328 37 tubular tubular JJ cord-015306-us58wwmp 2328 38 repair repair NN cord-015306-us58wwmp 2328 39 . . . cord-015306-us58wwmp 2329 1 Furthermore furthermore RB cord-015306-us58wwmp 2329 2 , , , cord-015306-us58wwmp 2329 3 87 87 CD cord-015306-us58wwmp 2329 4 % % NN cord-015306-us58wwmp 2329 5 proximal proximal JJ cord-015306-us58wwmp 2329 6 tubular tubular JJ cord-015306-us58wwmp 2329 7 cells cell NNS cord-015306-us58wwmp 2329 8 with with IN cord-015306-us58wwmp 2329 9 mTOR mTOR NNP cord-015306-us58wwmp 2329 10 activation activation NN cord-015306-us58wwmp 2329 11 indicated indicate VBN cord-015306-us58wwmp 2329 12 by by IN cord-015306-us58wwmp 2329 13 p p NN cord-015306-us58wwmp 2329 14 - - HYPH cord-015306-us58wwmp 2329 15 S6 S6 NNP cord-015306-us58wwmp 2329 16 kinase kinase NN cord-015306-us58wwmp 2329 17 expression expression NN cord-015306-us58wwmp 2329 18 contained contain VBD cord-015306-us58wwmp 2329 19 no no DT cord-015306-us58wwmp 2329 20 RFP RFP NNP cord-015306-us58wwmp 2329 21 puncta puncta NN cord-015306-us58wwmp 2329 22 . . . cord-015306-us58wwmp 2330 1 Inhibition inhibition NN cord-015306-us58wwmp 2330 2 of of IN cord-015306-us58wwmp 2330 3 mTORC1 mTORC1 NNP cord-015306-us58wwmp 2330 4 activity activity NN cord-015306-us58wwmp 2330 5 with with IN cord-015306-us58wwmp 2330 6 rapamycin rapamycin NNS cord-015306-us58wwmp 2330 7 caused cause VBD cord-015306-us58wwmp 2330 8 a a DT cord-015306-us58wwmp 2330 9 2-fold 2-fold CD cord-015306-us58wwmp 2330 10 decrease decrease NN cord-015306-us58wwmp 2330 11 in in IN cord-015306-us58wwmp 2330 12 cell cell NN cord-015306-us58wwmp 2330 13 proliferation proliferation NN cord-015306-us58wwmp 2330 14 . . . cord-015306-us58wwmp 2331 1 Conclusion conclusion NN cord-015306-us58wwmp 2331 2 : : : cord-015306-us58wwmp 2332 1 Our -PRON- PRP$ cord-015306-us58wwmp 2332 2 results result NNS cord-015306-us58wwmp 2332 3 highlight highlight VBP cord-015306-us58wwmp 2332 4 the the DT cord-015306-us58wwmp 2332 5 dynamic dynamic JJ cord-015306-us58wwmp 2332 6 regulation regulation NN cord-015306-us58wwmp 2332 7 of of IN cord-015306-us58wwmp 2332 8 autophagy autophagy NN cord-015306-us58wwmp 2332 9 in in IN cord-015306-us58wwmp 2332 10 post post JJ cord-015306-us58wwmp 2332 11 - - JJ cord-015306-us58wwmp 2332 12 ischemic ischemic JJ cord-015306-us58wwmp 2332 13 kidneys kidney NNS cord-015306-us58wwmp 2332 14 and and CC cord-015306-us58wwmp 2332 15 suggest suggest VBP cord-015306-us58wwmp 2332 16 a a DT cord-015306-us58wwmp 2332 17 role role NN cord-015306-us58wwmp 2332 18 of of IN cord-015306-us58wwmp 2332 19 mTOR mTOR NNP cord-015306-us58wwmp 2332 20 in in IN cord-015306-us58wwmp 2332 21 autophagy autophagy NN cord-015306-us58wwmp 2332 22 resolution resolution NN cord-015306-us58wwmp 2332 23 during during IN cord-015306-us58wwmp 2332 24 renal renal JJ cord-015306-us58wwmp 2332 25 repair repair NN cord-015306-us58wwmp 2332 26 . . . cord-015306-us58wwmp 2333 1 Abstract abstract JJ cord-015306-us58wwmp 2333 2 # # NN cord-015306-us58wwmp 2334 1 P p NN cord-015306-us58wwmp 2334 2 - - HYPH cord-015306-us58wwmp 2334 3 SAT297 SAT297 NNP cord-015306-us58wwmp 2334 4 Novel Novel NNP cord-015306-us58wwmp 2334 5 mechanisms mechanism NNS cord-015306-us58wwmp 2334 6 by by IN cord-015306-us58wwmp 2334 7 which which WDT cord-015306-us58wwmp 2334 8 Heparin Heparin NNP cord-015306-us58wwmp 2334 9 can can MD cord-015306-us58wwmp 2334 10 regulate regulate VB cord-015306-us58wwmp 2334 11 the the DT cord-015306-us58wwmp 2334 12 vascular vascular JJ cord-015306-us58wwmp 2334 13 activity activity NN cord-015306-us58wwmp 2334 14 of of IN cord-015306-us58wwmp 2334 15 Angiotensin Angiotensin NNP cord-015306-us58wwmp 2334 16 II II NNP cord-015306-us58wwmp 2334 17 ( ( -LRB- cord-015306-us58wwmp 2334 18 Ang Ang NNP cord-015306-us58wwmp 2334 19 - - HYPH cord-015306-us58wwmp 2334 20 II II NNP cord-015306-us58wwmp 2334 21 ) ) -RRB- cord-015306-us58wwmp 2334 22 and and CC cord-015306-us58wwmp 2334 23 Fibroblast Fibroblast NNP cord-015306-us58wwmp 2334 24 Growth Growth NNP cord-015306-us58wwmp 2334 25 Factor-2 Factor-2 NNP cord-015306-us58wwmp 2334 26 ( ( -LRB- cord-015306-us58wwmp 2334 27 FGF-2 FGF-2 NNP cord-015306-us58wwmp 2334 28 ) ) -RRB- cord-015306-us58wwmp 2334 29 and and CC cord-015306-us58wwmp 2334 30 affect affect VB cord-015306-us58wwmp 2334 31 the the DT cord-015306-us58wwmp 2334 32 outcome outcome NN cord-015306-us58wwmp 2334 33 of of IN cord-015306-us58wwmp 2334 34 acute acute JJ cord-015306-us58wwmp 2334 35 kidney kidney NN cord-015306-us58wwmp 2334 36 injury injury NN cord-015306-us58wwmp 2334 37 ( ( -LRB- cord-015306-us58wwmp 2334 38 AKI AKI NNP cord-015306-us58wwmp 2334 39 ) ) -RRB- cord-015306-us58wwmp 2335 1 Objective objective NN cord-015306-us58wwmp 2335 2 : : : cord-015306-us58wwmp 2335 3 Critically critically RB cord-015306-us58wwmp 2335 4 ill ill JJ cord-015306-us58wwmp 2335 5 children child NNS cord-015306-us58wwmp 2335 6 treated treat VBN cord-015306-us58wwmp 2335 7 with with IN cord-015306-us58wwmp 2335 8 extracorporeal extracorporeal JJ cord-015306-us58wwmp 2335 9 membrane membrane NN cord-015306-us58wwmp 2335 10 oxygenation oxygenation NN cord-015306-us58wwmp 2335 11 ( ( -LRB- cord-015306-us58wwmp 2335 12 ECMO ECMO NNP cord-015306-us58wwmp 2335 13 ) ) -RRB- cord-015306-us58wwmp 2336 1 and/or and/or CC cord-015306-us58wwmp 2337 1 cardiopulmonary cardiopulmonary JJ cord-015306-us58wwmp 2337 2 bypass bypass NNP cord-015306-us58wwmp 2337 3 ( ( -LRB- cord-015306-us58wwmp 2337 4 CPB CPB NNP cord-015306-us58wwmp 2337 5 ) ) -RRB- cord-015306-us58wwmp 2337 6 frequently frequently RB cord-015306-us58wwmp 2337 7 develop develop VBP cord-015306-us58wwmp 2337 8 hypertension hypertension NN cord-015306-us58wwmp 2337 9 , , , cord-015306-us58wwmp 2337 10 endothelial endothelial JJ cord-015306-us58wwmp 2337 11 dysfunction dysfunction NN cord-015306-us58wwmp 2337 12 , , , cord-015306-us58wwmp 2337 13 and and CC cord-015306-us58wwmp 2337 14 acute acute JJ cord-015306-us58wwmp 2337 15 kidney kidney NN cord-015306-us58wwmp 2337 16 injury injury NN cord-015306-us58wwmp 2337 17 ( ( -LRB- cord-015306-us58wwmp 2337 18 AKI AKI NNP cord-015306-us58wwmp 2337 19 ) ) -RRB- cord-015306-us58wwmp 2337 20 . . . cord-015306-us58wwmp 2338 1 These these DT cord-015306-us58wwmp 2338 2 patients patient NNS cord-015306-us58wwmp 2338 3 show show VBP cord-015306-us58wwmp 2338 4 high high JJ cord-015306-us58wwmp 2338 5 serum serum NN cord-015306-us58wwmp 2338 6 levels level NNS cord-015306-us58wwmp 2338 7 of of IN cord-015306-us58wwmp 2338 8 Ang Ang NNP cord-015306-us58wwmp 2338 9 - - HYPH cord-015306-us58wwmp 2338 10 II II NNP cord-015306-us58wwmp 2338 11 and and CC cord-015306-us58wwmp 2338 12 FGF-2 FGF-2 NNP cord-015306-us58wwmp 2338 13 , , , cord-015306-us58wwmp 2338 14 and and CC cord-015306-us58wwmp 2338 15 are be VBP cord-015306-us58wwmp 2338 16 treated treat VBN cord-015306-us58wwmp 2338 17 with with IN cord-015306-us58wwmp 2338 18 heparin heparin NN cord-015306-us58wwmp 2338 19 to to TO cord-015306-us58wwmp 2338 20 prevent prevent VB cord-015306-us58wwmp 2338 21 clotting clotting NN cord-015306-us58wwmp 2338 22 disorders disorder NNS cord-015306-us58wwmp 2338 23 . . . cord-015306-us58wwmp 2339 1 However however RB cord-015306-us58wwmp 2339 2 , , , cord-015306-us58wwmp 2339 3 the the DT cord-015306-us58wwmp 2339 4 mechanisms mechanism NNS cord-015306-us58wwmp 2339 5 by by IN cord-015306-us58wwmp 2339 6 which which WDT cord-015306-us58wwmp 2339 7 heparin heparin NN cord-015306-us58wwmp 2339 8 may may MD cord-015306-us58wwmp 2339 9 affect affect VB cord-015306-us58wwmp 2339 10 the the DT cord-015306-us58wwmp 2339 11 vascular vascular JJ cord-015306-us58wwmp 2339 12 activity activity NN cord-015306-us58wwmp 2339 13 of of IN cord-015306-us58wwmp 2339 14 Ang Ang NNP cord-015306-us58wwmp 2339 15 - - HYPH cord-015306-us58wwmp 2339 16 II II NNP cord-015306-us58wwmp 2339 17 and and CC cord-015306-us58wwmp 2339 18 FGF-2 FGF-2 NNP cord-015306-us58wwmp 2339 19 are be VBP cord-015306-us58wwmp 2339 20 not not RB cord-015306-us58wwmp 2339 21 clearly clearly RB cord-015306-us58wwmp 2339 22 understood understand VBN cord-015306-us58wwmp 2339 23 . . . cord-015306-us58wwmp 2340 1 We -PRON- PRP cord-015306-us58wwmp 2340 2 carried carry VBD cord-015306-us58wwmp 2340 3 out out RP cord-015306-us58wwmp 2340 4 this this DT cord-015306-us58wwmp 2340 5 study study NN cord-015306-us58wwmp 2340 6 to to TO cord-015306-us58wwmp 2340 7 determine determine VB cord-015306-us58wwmp 2340 8 whether whether IN cord-015306-us58wwmp 2340 9 heparin heparin NN cord-015306-us58wwmp 2340 10 can can MD cord-015306-us58wwmp 2340 11 modulate modulate VB cord-015306-us58wwmp 2340 12 the the DT cord-015306-us58wwmp 2340 13 vascular vascular JJ cord-015306-us58wwmp 2340 14 activity activity NN cord-015306-us58wwmp 2340 15 of of IN cord-015306-us58wwmp 2340 16 Ang Ang NNP cord-015306-us58wwmp 2340 17 - - HYPH cord-015306-us58wwmp 2340 18 II II NNP cord-015306-us58wwmp 2340 19 and and CC cord-015306-us58wwmp 2340 20 FGF-2 FGF-2 NNP cord-015306-us58wwmp 2340 21 by by IN cord-015306-us58wwmp 2340 22 affecting affect VBG cord-015306-us58wwmp 2340 23 the the DT cord-015306-us58wwmp 2340 24 Rho Rho NNP cord-015306-us58wwmp 2340 25 - - HYPH cord-015306-us58wwmp 2340 26 A A NNP cord-015306-us58wwmp 2340 27 , , , cord-015306-us58wwmp 2340 28 Rac-1 Rac-1 NNP cord-015306-us58wwmp 2340 29 , , , cord-015306-us58wwmp 2340 30 Src Src NNP cord-015306-us58wwmp 2340 31 , , , cord-015306-us58wwmp 2340 32 and and CC cord-015306-us58wwmp 2340 33 PKC PKC NNP cord-015306-us58wwmp 2340 34 signaling signal VBG cord-015306-us58wwmp 2340 35 pathways pathway NNS cord-015306-us58wwmp 2340 36 . . . cord-015306-us58wwmp 2341 1 Methods method NNS cord-015306-us58wwmp 2341 2 : : : cord-015306-us58wwmp 2342 1 Normal normal JJ cord-015306-us58wwmp 2342 2 FVB FVB NNP cord-015306-us58wwmp 2342 3 / / SYM cord-015306-us58wwmp 2342 4 N n CD cord-015306-us58wwmp 2342 5 mice mouse NNS cord-015306-us58wwmp 2342 6 were be VBD cord-015306-us58wwmp 2342 7 injected inject VBN cord-015306-us58wwmp 2342 8 with with IN cord-015306-us58wwmp 2342 9 adenoviral adenoviral JJ cord-015306-us58wwmp 2342 10 vectors vector NNS cord-015306-us58wwmp 2342 11 carrying carry VBG cord-015306-us58wwmp 2342 12 a a DT cord-015306-us58wwmp 2342 13 secreted secrete VBN cord-015306-us58wwmp 2342 14 form form NN cord-015306-us58wwmp 2342 15 of of IN cord-015306-us58wwmp 2342 16 human human JJ cord-015306-us58wwmp 2342 17 FGF-2 FGF-2 NNP cord-015306-us58wwmp 2342 18 or or CC cord-015306-us58wwmp 2342 19 Lac Lac NNP cord-015306-us58wwmp 2342 20 Z Z NNP cord-015306-us58wwmp 2342 21 vectors vector NNS cord-015306-us58wwmp 2342 22 , , , cord-015306-us58wwmp 2342 23 and and CC cord-015306-us58wwmp 2342 24 treated treat VBN cord-015306-us58wwmp 2342 25 with with IN cord-015306-us58wwmp 2342 26 heparin heparin NN cord-015306-us58wwmp 2342 27 ( ( -LRB- cord-015306-us58wwmp 2342 28 5,000 5,000 CD cord-015306-us58wwmp 2342 29 U U NNP cord-015306-us58wwmp 2342 30 / / SYM cord-015306-us58wwmp 2342 31 kg kg NNP cord-015306-us58wwmp 2342 32 ) ) -RRB- cord-015306-us58wwmp 2342 33 or or CC cord-015306-us58wwmp 2342 34 control control NN cord-015306-us58wwmp 2342 35 buffer buffer NN cord-015306-us58wwmp 2342 36 ( ( -LRB- cord-015306-us58wwmp 2342 37 n=5 n=5 JJ cord-015306-us58wwmp 2342 38 per per IN cord-015306-us58wwmp 2342 39 group group NN cord-015306-us58wwmp 2342 40 ) ) -RRB- cord-015306-us58wwmp 2342 41 . . . cord-015306-us58wwmp 2343 1 Vascular vascular JJ cord-015306-us58wwmp 2343 2 contractility contractility NN cord-015306-us58wwmp 2343 3 was be VBD cord-015306-us58wwmp 2343 4 studied study VBN cord-015306-us58wwmp 2343 5 in in IN cord-015306-us58wwmp 2343 6 pressurized pressurize VBN cord-015306-us58wwmp 2343 7 isolated isolated JJ cord-015306-us58wwmp 2343 8 resistance resistance NN cord-015306-us58wwmp 2343 9 - - HYPH cord-015306-us58wwmp 2343 10 sized sized JJ cord-015306-us58wwmp 2343 11 mouse mouse NN cord-015306-us58wwmp 2343 12 mesenteric mesenteric JJ cord-015306-us58wwmp 2343 13 arteries artery NNS cord-015306-us58wwmp 2343 14 , , , cord-015306-us58wwmp 2343 15 in in IN cord-015306-us58wwmp 2343 16 the the DT cord-015306-us58wwmp 2343 17 presence presence NN cord-015306-us58wwmp 2343 18 and and CC cord-015306-us58wwmp 2343 19 absence absence NN cord-015306-us58wwmp 2343 20 of of IN cord-015306-us58wwmp 2343 21 Ang Ang NNP cord-015306-us58wwmp 2343 22 - - HYPH cord-015306-us58wwmp 2343 23 II II NNP cord-015306-us58wwmp 2343 24 and and CC cord-015306-us58wwmp 2343 25 FGF-2 FGF-2 NNP cord-015306-us58wwmp 2343 26 . . . cord-015306-us58wwmp 2344 1 The the DT cord-015306-us58wwmp 2344 2 activation activation NN cord-015306-us58wwmp 2344 3 of of IN cord-015306-us58wwmp 2344 4 the the DT cord-015306-us58wwmp 2344 5 Src Src NNP cord-015306-us58wwmp 2344 6 , , , cord-015306-us58wwmp 2344 7 Rho Rho NNP cord-015306-us58wwmp 2344 8 - - HYPH cord-015306-us58wwmp 2344 9 A A NNP cord-015306-us58wwmp 2344 10 , , , cord-015306-us58wwmp 2344 11 Rac-1 Rac-1 NNP cord-015306-us58wwmp 2344 12 , , , cord-015306-us58wwmp 2344 13 and and CC cord-015306-us58wwmp 2344 14 PKC PKC NNP cord-015306-us58wwmp 2344 15 signaling signal VBG cord-015306-us58wwmp 2344 16 pathways pathway NNS cord-015306-us58wwmp 2344 17 were be VBD cord-015306-us58wwmp 2344 18 assessed assess VBN cord-015306-us58wwmp 2344 19 by by IN cord-015306-us58wwmp 2344 20 pull pull NN cord-015306-us58wwmp 2344 21 - - HYPH cord-015306-us58wwmp 2344 22 down down RP cord-015306-us58wwmp 2344 23 assays assay NNS cord-015306-us58wwmp 2344 24 and and CC cord-015306-us58wwmp 2344 25 Western western JJ cord-015306-us58wwmp 2344 26 blots blot NNS cord-015306-us58wwmp 2344 27 , , , cord-015306-us58wwmp 2344 28 both both CC cord-015306-us58wwmp 2344 29 in in IN cord-015306-us58wwmp 2344 30 vivo vivo NN cord-015306-us58wwmp 2344 31 and and CC cord-015306-us58wwmp 2344 32 in in IN cord-015306-us58wwmp 2344 33 vitro vitro FW cord-015306-us58wwmp 2344 34 . . . cord-015306-us58wwmp 2345 1 Permeability permeability NN cord-015306-us58wwmp 2345 2 changes change NNS cord-015306-us58wwmp 2345 3 were be VBD cord-015306-us58wwmp 2345 4 explored explore VBN cord-015306-us58wwmp 2345 5 in in IN cord-015306-us58wwmp 2345 6 cultured cultured JJ cord-015306-us58wwmp 2345 7 human human JJ cord-015306-us58wwmp 2345 8 renal renal JJ cord-015306-us58wwmp 2345 9 glomerular glomerular JJ cord-015306-us58wwmp 2345 10 endothelial endothelial JJ cord-015306-us58wwmp 2345 11 cells cell NNS cord-015306-us58wwmp 2345 12 ( ( -LRB- cord-015306-us58wwmp 2345 13 HRGEc HRGEc NNS cord-015306-us58wwmp 2345 14 ) ) -RRB- cord-015306-us58wwmp 2345 15 using use VBG cord-015306-us58wwmp 2345 16 FITC FITC NNP cord-015306-us58wwmp 2345 17 - - HYPH cord-015306-us58wwmp 2345 18 dextran dextran NN cord-015306-us58wwmp 2345 19 . . . cord-015306-us58wwmp 2346 1 Results result NNS cord-015306-us58wwmp 2346 2 : : : cord-015306-us58wwmp 2347 1 Heparin Heparin NNP cord-015306-us58wwmp 2347 2 significantly significantly RB cord-015306-us58wwmp 2347 3 enhanced enhance VBD cord-015306-us58wwmp 2347 4 the the DT cord-015306-us58wwmp 2347 5 FGF-2-induced fgf-2-induced JJ cord-015306-us58wwmp 2347 6 activation activation NN cord-015306-us58wwmp 2347 7 of of IN cord-015306-us58wwmp 2347 8 Rho Rho NNP cord-015306-us58wwmp 2347 9 - - HYPH cord-015306-us58wwmp 2347 10 A a NN cord-015306-us58wwmp 2347 11 and and CC cord-015306-us58wwmp 2348 1 Rac-1 Rac-1 NNP cord-015306-us58wwmp 2348 2 in in IN cord-015306-us58wwmp 2348 3 the the DT cord-015306-us58wwmp 2348 4 kidney kidney NN cord-015306-us58wwmp 2348 5 and and CC cord-015306-us58wwmp 2348 6 isolated isolate VBN cord-015306-us58wwmp 2348 7 mouse mouse NN cord-015306-us58wwmp 2348 8 mesenteric mesenteric JJ cord-015306-us58wwmp 2348 9 vessels vessel NNS cord-015306-us58wwmp 2348 10 . . . cord-015306-us58wwmp 2349 1 In in IN cord-015306-us58wwmp 2349 2 addition addition NN cord-015306-us58wwmp 2349 3 , , , cord-015306-us58wwmp 2349 4 heparin heparin NN cord-015306-us58wwmp 2349 5 antagonized antagonize VBD cord-015306-us58wwmp 2349 6 the the DT cord-015306-us58wwmp 2349 7 Ang Ang NNP cord-015306-us58wwmp 2349 8 II II NNP cord-015306-us58wwmp 2349 9 - - HYPH cord-015306-us58wwmp 2349 10 induced induce VBN cord-015306-us58wwmp 2349 11 contractility contractility NN cord-015306-us58wwmp 2349 12 of of IN cord-015306-us58wwmp 2349 13 isolated isolated JJ cord-015306-us58wwmp 2349 14 mouse mouse NN cord-015306-us58wwmp 2349 15 mesenteric mesenteric JJ cord-015306-us58wwmp 2349 16 vessels vessel NNS cord-015306-us58wwmp 2349 17 through through IN cord-015306-us58wwmp 2349 18 Rho Rho NNP cord-015306-us58wwmp 2349 19 - - HYPH cord-015306-us58wwmp 2349 20 A A NNP cord-015306-us58wwmp 2349 21 and and CC cord-015306-us58wwmp 2349 22 PKC PKC NNP cord-015306-us58wwmp 2349 23 - - HYPH cord-015306-us58wwmp 2349 24 dependent dependent JJ cord-015306-us58wwmp 2349 25 pathways pathway NNS cord-015306-us58wwmp 2349 26 . . . cord-015306-us58wwmp 2350 1 These these DT cord-015306-us58wwmp 2350 2 changes change NNS cord-015306-us58wwmp 2350 3 were be VBD cord-015306-us58wwmp 2350 4 reverted revert VBN cord-015306-us58wwmp 2350 5 by by IN cord-015306-us58wwmp 2350 6 FGF-2 FGF-2 NNP cord-015306-us58wwmp 2350 7 , , , cord-015306-us58wwmp 2350 8 and and CC cord-015306-us58wwmp 2350 9 abolished abolish VBN cord-015306-us58wwmp 2350 10 by by IN cord-015306-us58wwmp 2350 11 the the DT cord-015306-us58wwmp 2350 12 Rho Rho NNP cord-015306-us58wwmp 2350 13 kinase kinase NN cord-015306-us58wwmp 2350 14 inhibitor inhibitor NN cord-015306-us58wwmp 2350 15 Y27632 Y27632 NNP cord-015306-us58wwmp 2350 16 . . . cord-015306-us58wwmp 2351 1 Both both DT cord-015306-us58wwmp 2351 2 heparin heparin NN cord-015306-us58wwmp 2351 3 and and CC cord-015306-us58wwmp 2351 4 FGF-2 FGF-2 NNP cord-015306-us58wwmp 2351 5 , , , cord-015306-us58wwmp 2351 6 acting act VBG cord-015306-us58wwmp 2351 7 in in IN cord-015306-us58wwmp 2351 8 a a DT cord-015306-us58wwmp 2351 9 synergistic synergistic JJ cord-015306-us58wwmp 2351 10 manner manner NN cord-015306-us58wwmp 2351 11 , , , cord-015306-us58wwmp 2351 12 increased increase VBD cord-015306-us58wwmp 2351 13 the the DT cord-015306-us58wwmp 2351 14 permeability permeability NN cord-015306-us58wwmp 2351 15 of of IN cord-015306-us58wwmp 2351 16 HREC HREC NNP cord-015306-us58wwmp 2351 17 by by IN cord-015306-us58wwmp 2351 18 activating activate VBG cord-015306-us58wwmp 2351 19 the the DT cord-015306-us58wwmp 2351 20 Rho Rho NNP cord-015306-us58wwmp 2351 21 - - HYPH cord-015306-us58wwmp 2351 22 A A NNP cord-015306-us58wwmp 2351 23 and and CC cord-015306-us58wwmp 2351 24 Src Src NNP cord-015306-us58wwmp 2351 25 signaling signal VBG cord-015306-us58wwmp 2351 26 pathways pathway NNS cord-015306-us58wwmp 2351 27 . . . cord-015306-us58wwmp 2352 1 Conclusion conclusion NN cord-015306-us58wwmp 2352 2 : : : cord-015306-us58wwmp 2353 1 We -PRON- PRP cord-015306-us58wwmp 2353 2 conclude conclude VBP cord-015306-us58wwmp 2353 3 that that IN cord-015306-us58wwmp 2353 4 heparin heparin NN cord-015306-us58wwmp 2353 5 and and CC cord-015306-us58wwmp 2353 6 FGF-2 FGF-2 NNP cord-015306-us58wwmp 2353 7 , , , cord-015306-us58wwmp 2353 8 acting act VBG cord-015306-us58wwmp 2353 9 in in IN cord-015306-us58wwmp 2353 10 a a DT cord-015306-us58wwmp 2353 11 synergistic synergistic JJ cord-015306-us58wwmp 2353 12 manner manner NN cord-015306-us58wwmp 2353 13 , , , cord-015306-us58wwmp 2353 14 can can MD cord-015306-us58wwmp 2353 15 modulate modulate VB cord-015306-us58wwmp 2353 16 the the DT cord-015306-us58wwmp 2353 17 activity activity NN cord-015306-us58wwmp 2353 18 of of IN cord-015306-us58wwmp 2353 19 Ang Ang NNP cord-015306-us58wwmp 2353 20 - - HYPH cord-015306-us58wwmp 2353 21 II II NNP cord-015306-us58wwmp 2353 22 in in IN cord-015306-us58wwmp 2353 23 the the DT cord-015306-us58wwmp 2353 24 kidney kidney NN cord-015306-us58wwmp 2353 25 , , , cord-015306-us58wwmp 2353 26 isolated isolate VBN cord-015306-us58wwmp 2353 27 resistance resistance NN cord-015306-us58wwmp 2353 28 vessels vessel NNS cord-015306-us58wwmp 2353 29 , , , cord-015306-us58wwmp 2353 30 and and CC cord-015306-us58wwmp 2353 31 cultured cultured JJ cord-015306-us58wwmp 2353 32 HRGEc HRGEc NNS cord-015306-us58wwmp 2353 33 . . . cord-015306-us58wwmp 2354 1 These these DT cord-015306-us58wwmp 2354 2 findings finding NNS cord-015306-us58wwmp 2354 3 clearly clearly RB cord-015306-us58wwmp 2354 4 identify identify VBP cord-015306-us58wwmp 2354 5 novel novel JJ cord-015306-us58wwmp 2354 6 mechanisms mechanism NNS cord-015306-us58wwmp 2354 7 by by IN cord-015306-us58wwmp 2354 8 which which WDT cord-015306-us58wwmp 2354 9 heparin heparin NN cord-015306-us58wwmp 2354 10 , , , cord-015306-us58wwmp 2354 11 acting act VBG cord-015306-us58wwmp 2354 12 alone alone RB cord-015306-us58wwmp 2354 13 or or CC cord-015306-us58wwmp 2354 14 in in IN cord-015306-us58wwmp 2354 15 combination combination NN cord-015306-us58wwmp 2354 16 with with IN cord-015306-us58wwmp 2354 17 FGF-2 FGF-2 NNP cord-015306-us58wwmp 2354 18 , , , cord-015306-us58wwmp 2354 19 may may MD cord-015306-us58wwmp 2354 20 affect affect VB cord-015306-us58wwmp 2354 21 the the DT cord-015306-us58wwmp 2354 22 control control NN cord-015306-us58wwmp 2354 23 of of IN cord-015306-us58wwmp 2354 24 blood blood NN cord-015306-us58wwmp 2354 25 pressure pressure NN cord-015306-us58wwmp 2354 26 , , , cord-015306-us58wwmp 2354 27 renal renal JJ cord-015306-us58wwmp 2354 28 perfussion perfussion NN cord-015306-us58wwmp 2354 29 , , , cord-015306-us58wwmp 2354 30 and and CC cord-015306-us58wwmp 2354 31 capillary capillary JJ cord-015306-us58wwmp 2354 32 permeability permeability NN cord-015306-us58wwmp 2354 33 in in IN cord-015306-us58wwmp 2354 34 critically critically RB cord-015306-us58wwmp 2354 35 ill ill JJ cord-015306-us58wwmp 2354 36 children child NNS cord-015306-us58wwmp 2354 37 treated treat VBN cord-015306-us58wwmp 2354 38 with with IN cord-015306-us58wwmp 2354 39 ECMO ECMO NNP cord-015306-us58wwmp 2354 40 and and CC cord-015306-us58wwmp 2354 41 CPB CPB NNP cord-015306-us58wwmp 2354 42 . . . cord-015306-us58wwmp 2355 1 Abstract abstract JJ cord-015306-us58wwmp 2355 2 # # NN cord-015306-us58wwmp 2355 3 P p NN cord-015306-us58wwmp 2355 4 - - HYPH cord-015306-us58wwmp 2355 5 SAT298 SAT298 NNP cord-015306-us58wwmp 2355 6 Cisplatinum Cisplatinum NNP cord-015306-us58wwmp 2355 7 ( ( -LRB- cord-015306-us58wwmp 2355 8 Cis Cis NNP cord-015306-us58wwmp 2355 9 ) ) -RRB- cord-015306-us58wwmp 2355 10 toxicity toxicity NN cord-015306-us58wwmp 2355 11 in in IN cord-015306-us58wwmp 2355 12 immortalized immortalize VBN cord-015306-us58wwmp 2355 13 human human JJ cord-015306-us58wwmp 2355 14 kidney kidney NN cord-015306-us58wwmp 2355 15 ( ( -LRB- cord-015306-us58wwmp 2355 16 HK-2 HK-2 NNP cord-015306-us58wwmp 2355 17 ) ) -RRB- cord-015306-us58wwmp 2355 18 proximal proximal VBD cord-015306-us58wwmp 2355 19 tubular tubular JJ cord-015306-us58wwmp 2355 20 epithelial epithelial JJ cord-015306-us58wwmp 2355 21 cells cell NNS cord-015306-us58wwmp 2355 22 is be VBZ cord-015306-us58wwmp 2355 23 independent independent JJ cord-015306-us58wwmp 2355 24 of of IN cord-015306-us58wwmp 2355 25 DNA dna NN cord-015306-us58wwmp 2355 26 strand strand NN cord-015306-us58wwmp 2355 27 breaks break NNS cord-015306-us58wwmp 2355 28 and and CC cord-015306-us58wwmp 2355 29 has have VBZ cord-015306-us58wwmp 2355 30 implications implication NNS cord-015306-us58wwmp 2355 31 for for IN cord-015306-us58wwmp 2355 32 biology biology NN cord-015306-us58wwmp 2355 33 and and CC cord-015306-us58wwmp 2355 34 therapy therapy NN cord-015306-us58wwmp 2355 35 of of IN cord-015306-us58wwmp 2356 1 renal renal JJ cord-015306-us58wwmp 2356 2 cell cell NN cord-015306-us58wwmp 2356 3 carcinoma carcinoma NN cord-015306-us58wwmp 2356 4 ( ( -LRB- cord-015306-us58wwmp 2356 5 RCC RCC NNP cord-015306-us58wwmp 2356 6 ) ) -RRB- cord-015306-us58wwmp 2356 7 Results result VBZ cord-015306-us58wwmp 2356 8 : : : cord-015306-us58wwmp 2356 9 Viability viability NN cord-015306-us58wwmp 2356 10 of of IN cord-015306-us58wwmp 2356 11 HuH-7 HuH-7 NNP cord-015306-us58wwmp 2356 12 and and CC cord-015306-us58wwmp 2356 13 HK-2 HK-2 NNP cord-015306-us58wwmp 2356 14 cells cell NNS cord-015306-us58wwmp 2356 15 decreased decrease VBD cord-015306-us58wwmp 2356 16 similarly similarly RB cord-015306-us58wwmp 2356 17 after after IN cord-015306-us58wwmp 2356 18 IC50 ic50 JJ cord-015306-us58wwmp 2356 19 doses dose NNS cord-015306-us58wwmp 2356 20 of of IN cord-015306-us58wwmp 2356 21 Cis Cis NNP cord-015306-us58wwmp 2356 22 with with IN cord-015306-us58wwmp 2356 23 morphology morphology NN cord-015306-us58wwmp 2356 24 and and CC cord-015306-us58wwmp 2356 25 MTT MTT NNP cord-015306-us58wwmp 2356 26 assays assay NNS cord-015306-us58wwmp 2356 27 . . . cord-015306-us58wwmp 2357 1 Many many JJ cord-015306-us58wwmp 2357 2 DNA dna NN cord-015306-us58wwmp 2357 3 damage damage NN cord-015306-us58wwmp 2357 4 genes gene NNS cord-015306-us58wwmp 2357 5 , , , cord-015306-us58wwmp 2357 6 including include VBG cord-015306-us58wwmp 2357 7 ATM atm NN cord-015306-us58wwmp 2357 8 - - HYPH cord-015306-us58wwmp 2357 9 related relate VBN cord-015306-us58wwmp 2357 10 genes gene NNS cord-015306-us58wwmp 2357 11 , , , cord-015306-us58wwmp 2357 12 were be VBD cord-015306-us58wwmp 2357 13 expressed express VBN cord-015306-us58wwmp 2357 14 less less JJR cord-015306-us58wwmp 2357 15 at at IN cord-015306-us58wwmp 2357 16 mRNA mRNA NNP cord-015306-us58wwmp 2357 17 and and CC cord-015306-us58wwmp 2357 18 protein protein NN cord-015306-us58wwmp 2357 19 levels level NNS cord-015306-us58wwmp 2357 20 in in IN cord-015306-us58wwmp 2357 21 both both DT cord-015306-us58wwmp 2357 22 cell cell NN cord-015306-us58wwmp 2357 23 types type NNS cord-015306-us58wwmp 2357 24 . . . cord-015306-us58wwmp 2358 1 However however RB cord-015306-us58wwmp 2358 2 , , , cord-015306-us58wwmp 2358 3 p53 p53 NN cord-015306-us58wwmp 2358 4 expression expression NN cord-015306-us58wwmp 2358 5 decreased decrease VBD cord-015306-us58wwmp 2358 6 in in IN cord-015306-us58wwmp 2358 7 HK-2 HK-2 NNP cord-015306-us58wwmp 2358 8 cells cell NNS cord-015306-us58wwmp 2358 9 . . . cord-015306-us58wwmp 2359 1 Comet Comet NNP cord-015306-us58wwmp 2359 2 assays assay NNS cord-015306-us58wwmp 2359 3 showed show VBD cord-015306-us58wwmp 2359 4 extensive extensive JJ cord-015306-us58wwmp 2359 5 DNA dna NN cord-015306-us58wwmp 2359 6 strand strand NN cord-015306-us58wwmp 2359 7 breaks break NNS cord-015306-us58wwmp 2359 8 in in IN cord-015306-us58wwmp 2359 9 HuH-7 HuH-7 NNP cord-015306-us58wwmp 2359 10 but but CC cord-015306-us58wwmp 2359 11 not not RB cord-015306-us58wwmp 2359 12 in in IN cord-015306-us58wwmp 2359 13 HK-2 HK-2 NNP cord-015306-us58wwmp 2359 14 cells cell NNS cord-015306-us58wwmp 2359 15 . . . cord-015306-us58wwmp 2360 1 ATM atm NN cord-015306-us58wwmp 2360 2 promoter promoter NN cord-015306-us58wwmp 2360 3 activity activity NN cord-015306-us58wwmp 2360 4 increased increase VBD cord-015306-us58wwmp 2360 5 in in IN cord-015306-us58wwmp 2360 6 only only JJ cord-015306-us58wwmp 2360 7 HuH-7 HuH-7 NNP cord-015306-us58wwmp 2360 8 cells cell NNS cord-015306-us58wwmp 2360 9 . . . cord-015306-us58wwmp 2361 1 Also also RB cord-015306-us58wwmp 2361 2 , , , cord-015306-us58wwmp 2361 3 S S NNP cord-015306-us58wwmp 2361 4 and and CC cord-015306-us58wwmp 2361 5 G2 G2 NNP cord-015306-us58wwmp 2361 6 / / SYM cord-015306-us58wwmp 2361 7 M M NNP cord-015306-us58wwmp 2361 8 populations population NNS cord-015306-us58wwmp 2361 9 were be VBD cord-015306-us58wwmp 2361 10 depleted deplete VBN cord-015306-us58wwmp 2361 11 by by IN cord-015306-us58wwmp 2361 12 FACS FACS NNP cord-015306-us58wwmp 2361 13 in in IN cord-015306-us58wwmp 2361 14 HuH-7 HuH-7 NNP cord-015306-us58wwmp 2361 15 but but CC cord-015306-us58wwmp 2361 16 not not RB cord-015306-us58wwmp 2361 17 HK-2 HK-2 NNP cord-015306-us58wwmp 2361 18 cells cell NNS cord-015306-us58wwmp 2361 19 . . . cord-015306-us58wwmp 2362 1 Conclusion conclusion NN cord-015306-us58wwmp 2362 2 : : : cord-015306-us58wwmp 2362 3 HK-2 HK-2 NNP cord-015306-us58wwmp 2362 4 cells cell NNS cord-015306-us58wwmp 2362 5 transformed transform VBN cord-015306-us58wwmp 2362 6 by by IN cord-015306-us58wwmp 2362 7 HPV hpv NN cord-015306-us58wwmp 2362 8 E6/7 E6/7 NNP cord-015306-us58wwmp 2362 9 oncogenes oncogene NNS cord-015306-us58wwmp 2362 10 displayed display VBD cord-015306-us58wwmp 2362 11 independence independence NN cord-015306-us58wwmp 2362 12 from from IN cord-015306-us58wwmp 2362 13 Cis Cis NNP cord-015306-us58wwmp 2362 14 - - HYPH cord-015306-us58wwmp 2362 15 induced induce VBN cord-015306-us58wwmp 2362 16 DNA dna NN cord-015306-us58wwmp 2362 17 breaks break NNS cord-015306-us58wwmp 2362 18 and and CC cord-015306-us58wwmp 2362 19 ATMmediated atmmediated JJ cord-015306-us58wwmp 2362 20 cell cell NN cord-015306-us58wwmp 2362 21 cycle cycle NN cord-015306-us58wwmp 2362 22 arrest arrest NN cord-015306-us58wwmp 2362 23 . . . cord-015306-us58wwmp 2363 1 Such such JJ cord-015306-us58wwmp 2363 2 independence independence NN cord-015306-us58wwmp 2363 3 from from IN cord-015306-us58wwmp 2363 4 genotoxicity genotoxicity NN cord-015306-us58wwmp 2363 5 will will MD cord-015306-us58wwmp 2363 6 help help VB cord-015306-us58wwmp 2363 7 explain explain VB cord-015306-us58wwmp 2363 8 mechanisms mechanism NNS cord-015306-us58wwmp 2363 9 imparting impart VBG cord-015306-us58wwmp 2363 10 resistance resistance NN cord-015306-us58wwmp 2363 11 to to IN cord-015306-us58wwmp 2363 12 chemo chemo NN cord-015306-us58wwmp 2363 13 - - , cord-015306-us58wwmp 2363 14 or or CC cord-015306-us58wwmp 2363 15 radiotherapy radiotherapy NN cord-015306-us58wwmp 2363 16 and and CC cord-015306-us58wwmp 2363 17 invasiveness invasiveness NN cord-015306-us58wwmp 2363 18 in in IN cord-015306-us58wwmp 2363 19 RCC RCC NNP cord-015306-us58wwmp 2363 20 . . . cord-015306-us58wwmp 2364 1 Abstract abstract JJ cord-015306-us58wwmp 2364 2 # # NN cord-015306-us58wwmp 2364 3 P p NN cord-015306-us58wwmp 2364 4 - - HYPH cord-015306-us58wwmp 2364 5 SAT299 SAT299 NNP cord-015306-us58wwmp 2364 6 Renal renal JJ cord-015306-us58wwmp 2364 7 neutrophil neutrophil NN cord-015306-us58wwmp 2364 8 gelatinase gelatinase NN cord-015306-us58wwmp 2364 9 - - HYPH cord-015306-us58wwmp 2364 10 associated associate VBN cord-015306-us58wwmp 2364 11 lipocalin lipocalin NN cord-015306-us58wwmp 2364 12 and and CC cord-015306-us58wwmp 2364 13 kidney kidney NN cord-015306-us58wwmp 2364 14 injury injury NN cord-015306-us58wwmp 2364 15 molecule-1 molecule-1 NNP cord-015306-us58wwmp 2364 16 expression expression NN cord-015306-us58wwmp 2364 17 in in IN cord-015306-us58wwmp 2364 18 children child NNS cord-015306-us58wwmp 2364 19 with with IN cord-015306-us58wwmp 2364 20 acute acute JJ cord-015306-us58wwmp 2364 21 kidney kidney NN cord-015306-us58wwmp 2364 22 injury injury NN cord-015306-us58wwmp 2364 23 on on IN cord-015306-us58wwmp 2364 24 Henoch Henoch NNP cord-015306-us58wwmp 2364 25 - - HYPH cord-015306-us58wwmp 2364 26 Schonlein Schonlein NNP cord-015306-us58wwmp 2364 27 purpura purpura NN cord-015306-us58wwmp 2364 28 nephritis nephritis NN cord-015306-us58wwmp 2364 29 Yue Yue NNP cord-015306-us58wwmp 2364 30 Du Du NNP cord-015306-us58wwmp 2364 31 , , , cord-015306-us58wwmp 2364 32 Jinjie Jinjie NNP cord-015306-us58wwmp 2364 33 Guo Guo NNP cord-015306-us58wwmp 2364 34 , , , cord-015306-us58wwmp 2364 35 Ling Ling NNP cord-015306-us58wwmp 2364 36 Hou Hou NNP cord-015306-us58wwmp 2364 37 , , , cord-015306-us58wwmp 2364 38 Yubin Yubin NNP cord-015306-us58wwmp 2364 39 wu wu NNP cord-015306-us58wwmp 2364 40 , , , cord-015306-us58wwmp 2364 41 Tingting Tingting NNP cord-015306-us58wwmp 2364 42 Sun Sun NNP cord-015306-us58wwmp 2364 43 Paediatrics Paediatrics NNP cord-015306-us58wwmp 2364 44 , , , cord-015306-us58wwmp 2364 45 Post Post NNP cord-015306-us58wwmp 2364 46 Graduate Graduate NNP cord-015306-us58wwmp 2364 47 Trainee Trainee NNP cord-015306-us58wwmp 2364 48 , , , cord-015306-us58wwmp 2365 1 China China NNP cord-015306-us58wwmp 2365 2 Objective Objective NNP cord-015306-us58wwmp 2365 3 : : : cord-015306-us58wwmp 2365 4 To to TO cord-015306-us58wwmp 2365 5 evaluate evaluate VB cord-015306-us58wwmp 2365 6 serum serum NN cord-015306-us58wwmp 2365 7 , , , cord-015306-us58wwmp 2365 8 urinary urinary JJ cord-015306-us58wwmp 2365 9 and and CC cord-015306-us58wwmp 2365 10 renal renal JJ cord-015306-us58wwmp 2365 11 neutrophil neutrophil NN cord-015306-us58wwmp 2365 12 gelatinaseassociated gelatinaseassociated JJ cord-015306-us58wwmp 2365 13 lipocalin(NGAL lipocalin(ngal CD cord-015306-us58wwmp 2365 14 ) ) -RRB- cord-015306-us58wwmp 2365 15 and and CC cord-015306-us58wwmp 2365 16 kidney kidney NN cord-015306-us58wwmp 2365 17 injury injury NN cord-015306-us58wwmp 2365 18 molecule-1(KIM-1 molecule-1(KIM-1 NNP cord-015306-us58wwmp 2365 19 ) ) -RRB- cord-015306-us58wwmp 2365 20 in in IN cord-015306-us58wwmp 2365 21 children child NNS cord-015306-us58wwmp 2365 22 with with IN cord-015306-us58wwmp 2365 23 AKI AKI NNP cord-015306-us58wwmp 2365 24 on on IN cord-015306-us58wwmp 2365 25 HSPN HSPN NNP cord-015306-us58wwmp 2365 26 by by IN cord-015306-us58wwmp 2365 27 pRIFLE prifle NN cord-015306-us58wwmp 2365 28 or or CC cord-015306-us58wwmp 2365 29 HSPN HSPN NNP cord-015306-us58wwmp 2365 30 with with IN cord-015306-us58wwmp 2365 31 nephroticrange nephroticrange NNP cord-015306-us58wwmp 2365 32 proteinuria proteinuria NNP cord-015306-us58wwmp 2365 33 . . . cord-015306-us58wwmp 2366 1 Methods method NNS cord-015306-us58wwmp 2366 2 : : : cord-015306-us58wwmp 2366 3 We -PRON- PRP cord-015306-us58wwmp 2366 4 performed perform VBD cord-015306-us58wwmp 2366 5 a a DT cord-015306-us58wwmp 2366 6 prospective prospective JJ cord-015306-us58wwmp 2366 7 single single JJ cord-015306-us58wwmp 2366 8 - - HYPH cord-015306-us58wwmp 2366 9 center center NN cord-015306-us58wwmp 2366 10 evaluation evaluation NN cord-015306-us58wwmp 2366 11 of of IN cord-015306-us58wwmp 2366 12 serum serum NN cord-015306-us58wwmp 2366 13 , , , cord-015306-us58wwmp 2366 14 urinary urinary JJ cord-015306-us58wwmp 2366 15 and and CC cord-015306-us58wwmp 2366 16 renal renal JJ cord-015306-us58wwmp 2366 17 NGAL NGAL NNP cord-015306-us58wwmp 2366 18 and and CC cord-015306-us58wwmp 2366 19 KIM-1 KIM-1 NNP cord-015306-us58wwmp 2366 20 in in IN cord-015306-us58wwmp 2366 21 a a DT cord-015306-us58wwmp 2366 22 cohort cohort NN cord-015306-us58wwmp 2366 23 of of IN cord-015306-us58wwmp 2366 24 children child NNS cord-015306-us58wwmp 2366 25 . . . cord-015306-us58wwmp 2367 1 We -PRON- PRP cord-015306-us58wwmp 2367 2 recorded record VBD cord-015306-us58wwmp 2367 3 any any DT cord-015306-us58wwmp 2367 4 relevant relevant JJ cord-015306-us58wwmp 2367 5 data datum NNS cord-015306-us58wwmp 2367 6 including include VBG cord-015306-us58wwmp 2367 7 age age NN cord-015306-us58wwmp 2367 8 , , , cord-015306-us58wwmp 2367 9 gender gender NN cord-015306-us58wwmp 2367 10 , , , cord-015306-us58wwmp 2367 11 weight weight NN cord-015306-us58wwmp 2367 12 , , , cord-015306-us58wwmp 2367 13 hemoglobin(Hb hemoglobin(Hb NNP cord-015306-us58wwmp 2367 14 ) ) -RRB- cord-015306-us58wwmp 2367 15 , , , cord-015306-us58wwmp 2367 16 serum serum NN cord-015306-us58wwmp 2367 17 creatinine(SCr creatinine(SCr NNP cord-015306-us58wwmp 2367 18 ) ) -RRB- cord-015306-us58wwmp 2367 19 , , , cord-015306-us58wwmp 2367 20 Cystatine Cystatine NNP cord-015306-us58wwmp 2367 21 C(CysC C(CysC NNP cord-015306-us58wwmp 2367 22 ) ) -RRB- cord-015306-us58wwmp 2367 23 , , , cord-015306-us58wwmp 2367 24 serum serum NN cord-015306-us58wwmp 2367 25 beta2-MG beta2-MG NNS cord-015306-us58wwmp 2367 26 , , , cord-015306-us58wwmp 2367 27 Albumine Albumine NNP cord-015306-us58wwmp 2367 28 , , , cord-015306-us58wwmp 2367 29 urine urine NN cord-015306-us58wwmp 2367 30 beta2-MG beta2-MG NNS cord-015306-us58wwmp 2367 31 , , , cord-015306-us58wwmp 2367 32 urine urine NN cord-015306-us58wwmp 2367 33 protein protein NN cord-015306-us58wwmp 2367 34 in in IN cord-015306-us58wwmp 2367 35 all all DT cord-015306-us58wwmp 2367 36 patients patient NNS cord-015306-us58wwmp 2367 37 . . . cord-015306-us58wwmp 2368 1 Each each DT cord-015306-us58wwmp 2368 2 patient patient NN cord-015306-us58wwmp 2368 3 's 's POS cord-015306-us58wwmp 2368 4 estimated estimate VBN cord-015306-us58wwmp 2368 5 creatinine creatinine NN cord-015306-us58wwmp 2368 6 clearance clearance NN cord-015306-us58wwmp 2368 7 was be VBD cord-015306-us58wwmp 2368 8 calculated calculate VBN cord-015306-us58wwmp 2368 9 using use VBG cord-015306-us58wwmp 2368 10 the the DT cord-015306-us58wwmp 2368 11 original original JJ cord-015306-us58wwmp 2368 12 Schwartz Schwartz NNP cord-015306-us58wwmp 2368 13 formula formula NN cord-015306-us58wwmp 2368 14 . . . cord-015306-us58wwmp 2369 1 Blood blood NN cord-015306-us58wwmp 2369 2 sample sample NN cord-015306-us58wwmp 2369 3 and and CC cord-015306-us58wwmp 2369 4 Five five CD cord-015306-us58wwmp 2369 5 ml ml NNS cord-015306-us58wwmp 2369 6 of of IN cord-015306-us58wwmp 2369 7 urine urine NN cord-015306-us58wwmp 2369 8 sample sample NN cord-015306-us58wwmp 2369 9 from from IN cord-015306-us58wwmp 2369 10 each each DT cord-015306-us58wwmp 2369 11 participating participate VBG cord-015306-us58wwmp 2369 12 patient patient NN cord-015306-us58wwmp 2369 13 were be VBD cord-015306-us58wwmp 2369 14 collected collect VBN cord-015306-us58wwmp 2369 15 for for IN cord-015306-us58wwmp 2369 16 NGAL NGAL NNP cord-015306-us58wwmp 2369 17 and and CC cord-015306-us58wwmp 2369 18 KIM-1 KIM-1 NNP cord-015306-us58wwmp 2369 19 using use VBG cord-015306-us58wwmp 2369 20 an an DT cord-015306-us58wwmp 2369 21 enzyme enzyme NN cord-015306-us58wwmp 2369 22 - - HYPH cord-015306-us58wwmp 2369 23 linked link VBN cord-015306-us58wwmp 2369 24 immunosorbent immunosorbent JJ cord-015306-us58wwmp 2369 25 assay assay NN cord-015306-us58wwmp 2369 26 . . . cord-015306-us58wwmp 2370 1 Analysis analysis NN cord-015306-us58wwmp 2370 2 of of IN cord-015306-us58wwmp 2370 3 proteins protein NNS cord-015306-us58wwmp 2370 4 NGAL NGAL NNP cord-015306-us58wwmp 2370 5 and and CC cord-015306-us58wwmp 2370 6 KIM-1 KIM-1 NNP cord-015306-us58wwmp 2370 7 using use VBG cord-015306-us58wwmp 2370 8 SABC SABC NNP cord-015306-us58wwmp 2370 9 immunohistochemical immunohistochemical JJ cord-015306-us58wwmp 2370 10 assay assay NN cord-015306-us58wwmp 2370 11 . . . cord-015306-us58wwmp 2371 1 Results result NNS cord-015306-us58wwmp 2371 2 : : : cord-015306-us58wwmp 2372 1 Twenty twenty CD cord-015306-us58wwmp 2372 2 five five CD cord-015306-us58wwmp 2372 3 patients patient NNS cord-015306-us58wwmp 2372 4 were be VBD cord-015306-us58wwmp 2372 5 enrolled enrol VBN cord-015306-us58wwmp 2372 6 in in IN cord-015306-us58wwmp 2372 7 the the DT cord-015306-us58wwmp 2372 8 study study NN cord-015306-us58wwmp 2372 9 . . . cord-015306-us58wwmp 2373 1 Nine nine CD cord-015306-us58wwmp 2373 2 patients patient NNS cord-015306-us58wwmp 2373 3 with with IN cord-015306-us58wwmp 2373 4 AKI AKI NNP cord-015306-us58wwmp 2373 5 - - HYPH cord-015306-us58wwmp 2373 6 on on IN cord-015306-us58wwmp 2373 7 - - HYPH cord-015306-us58wwmp 2373 8 HSPN(A hspn(a NN cord-015306-us58wwmp 2373 9 - - HYPH cord-015306-us58wwmp 2373 10 on on IN cord-015306-us58wwmp 2373 11 - - HYPH cord-015306-us58wwmp 2373 12 C c NN cord-015306-us58wwmp 2373 13 ) ) -RRB- cord-015306-us58wwmp 2373 14 and and CC cord-015306-us58wwmp 2373 15 six six CD cord-015306-us58wwmp 2373 16 were be VBD cord-015306-us58wwmp 2373 17 done do VBN cord-015306-us58wwmp 2373 18 renal renal JJ cord-015306-us58wwmp 2373 19 biopsy biopsy NN cord-015306-us58wwmp 2373 20 , , , cord-015306-us58wwmp 2373 21 Sixteen sixteen CD cord-015306-us58wwmp 2373 22 patients patient NNS cord-015306-us58wwmp 2373 23 with with IN cord-015306-us58wwmp 2373 24 HSPN HSPN NNP cord-015306-us58wwmp 2373 25 with with IN cord-015306-us58wwmp 2373 26 nephrotic nephrotic JJ cord-015306-us58wwmp 2373 27 - - HYPH cord-015306-us58wwmp 2373 28 range range NN cord-015306-us58wwmp 2373 29 proteinuria proteinuria NN cord-015306-us58wwmp 2373 30 and and CC cord-015306-us58wwmp 2373 31 ten ten CD cord-015306-us58wwmp 2373 32 were be VBD cord-015306-us58wwmp 2373 33 done do VBN cord-015306-us58wwmp 2373 34 renal renal JJ cord-015306-us58wwmp 2373 35 biopsy biopsy NN cord-015306-us58wwmp 2373 36 . . . cord-015306-us58wwmp 2374 1 Blood blood NN cord-015306-us58wwmp 2374 2 cystatinC cystatinC NNP cord-015306-us58wwmp 2374 3 , , , cord-015306-us58wwmp 2374 4 beta2-MG beta2-MG NNS cord-015306-us58wwmp 2374 5 , , , cord-015306-us58wwmp 2374 6 SCr SCr NNS cord-015306-us58wwmp 2374 7 , , , cord-015306-us58wwmp 2374 8 NGAL NGAL NNP cord-015306-us58wwmp 2374 9 and and CC cord-015306-us58wwmp 2374 10 KIM-1 KIM-1 NNP cord-015306-us58wwmp 2374 11 were be VBD cord-015306-us58wwmp 2374 12 increased increase VBN cord-015306-us58wwmp 2374 13 significantly significantly RB cord-015306-us58wwmp 2374 14 in in IN cord-015306-us58wwmp 2374 15 patients patient NNS cord-015306-us58wwmp 2374 16 with with IN cord-015306-us58wwmp 2374 17 A a DT cord-015306-us58wwmp 2374 18 - - HYPH cord-015306-us58wwmp 2374 19 on on IN cord-015306-us58wwmp 2374 20 - - HYPH cord-015306-us58wwmp 2374 21 C c NN cord-015306-us58wwmp 2374 22 than than IN cord-015306-us58wwmp 2374 23 those those DT cord-015306-us58wwmp 2374 24 with with IN cord-015306-us58wwmp 2374 25 HSPN HSPN NNP cord-015306-us58wwmp 2374 26 , , , cord-015306-us58wwmp 2374 27 and and CC cord-015306-us58wwmp 2374 28 so so RB cord-015306-us58wwmp 2374 29 do do VB cord-015306-us58wwmp 2374 30 urine urine NN cord-015306-us58wwmp 2374 31 NGAL NGAL NNP cord-015306-us58wwmp 2374 32 , , , cord-015306-us58wwmp 2374 33 KIM-1 KIM-1 NNP cord-015306-us58wwmp 2374 34 and and CC cord-015306-us58wwmp 2374 35 beta2-MG beta2-MG NNS cord-015306-us58wwmp 2374 36 . . . cord-015306-us58wwmp 2375 1 There there EX cord-015306-us58wwmp 2375 2 was be VBD cord-015306-us58wwmp 2375 3 no no DT cord-015306-us58wwmp 2375 4 significant significant JJ cord-015306-us58wwmp 2375 5 difference difference NN cord-015306-us58wwmp 2375 6 of of IN cord-015306-us58wwmp 2375 7 proteinuria proteinuria NN cord-015306-us58wwmp 2375 8 between between IN cord-015306-us58wwmp 2375 9 the the DT cord-015306-us58wwmp 2375 10 patient patient NN cord-015306-us58wwmp 2375 11 with with IN cord-015306-us58wwmp 2375 12 A a DT cord-015306-us58wwmp 2375 13 - - HYPH cord-015306-us58wwmp 2375 14 on on IN cord-015306-us58wwmp 2375 15 - - HYPH cord-015306-us58wwmp 2375 16 C c NN cord-015306-us58wwmp 2375 17 and and CC cord-015306-us58wwmp 2375 18 the the DT cord-015306-us58wwmp 2375 19 patients patient NNS cord-015306-us58wwmp 2375 20 with with IN cord-015306-us58wwmp 2375 21 HSPN HSPN NNP cord-015306-us58wwmp 2375 22 . . . cord-015306-us58wwmp 2376 1 Immunohistochemical immunohistochemical JJ cord-015306-us58wwmp 2376 2 results result NNS cord-015306-us58wwmp 2376 3 showed show VBD cord-015306-us58wwmp 2376 4 that that IN cord-015306-us58wwmp 2376 5 NGAL NGAL NNP cord-015306-us58wwmp 2376 6 and and CC cord-015306-us58wwmp 2376 7 KIM-1 KIM-1 NNP cord-015306-us58wwmp 2376 8 were be VBD cord-015306-us58wwmp 2376 9 expressed express VBN cord-015306-us58wwmp 2376 10 in in IN cord-015306-us58wwmp 2376 11 proximal proximal JJ cord-015306-us58wwmp 2376 12 tubule tubule NN cord-015306-us58wwmp 2376 13 and and CC cord-015306-us58wwmp 2376 14 their -PRON- PRP$ cord-015306-us58wwmp 2376 15 expression expression NN cord-015306-us58wwmp 2376 16 were be VBD cord-015306-us58wwmp 2376 17 significantly significantly RB cord-015306-us58wwmp 2376 18 higher high JJR cord-015306-us58wwmp 2376 19 in in IN cord-015306-us58wwmp 2376 20 A a DT cord-015306-us58wwmp 2376 21 - - HYPH cord-015306-us58wwmp 2376 22 on on IN cord-015306-us58wwmp 2376 23 - - HYPH cord-015306-us58wwmp 2376 24 C c NN cord-015306-us58wwmp 2376 25 group group NN cord-015306-us58wwmp 2376 26 than than IN cord-015306-us58wwmp 2376 27 in in IN cord-015306-us58wwmp 2376 28 HSPN HSPN NNP cord-015306-us58wwmp 2376 29 group group NN cord-015306-us58wwmp 2376 30 . . . cord-015306-us58wwmp 2377 1 The the DT cord-015306-us58wwmp 2377 2 correlation correlation NN cord-015306-us58wwmp 2377 3 analysis analysis NN cord-015306-us58wwmp 2377 4 showed show VBD cord-015306-us58wwmp 2377 5 that that IN cord-015306-us58wwmp 2377 6 urine urine NN cord-015306-us58wwmp 2377 7 NGAL NGAL NNP cord-015306-us58wwmp 2377 8 and and CC cord-015306-us58wwmp 2377 9 KIM-1 KIM-1 NNP cord-015306-us58wwmp 2377 10 were be VBD cord-015306-us58wwmp 2377 11 negative negative JJ cord-015306-us58wwmp 2377 12 correlated correlate VBN cord-015306-us58wwmp 2377 13 with with IN cord-015306-us58wwmp 2377 14 GFR GFR NNP cord-015306-us58wwmp 2377 15 and and CC cord-015306-us58wwmp 2377 16 they -PRON- PRP cord-015306-us58wwmp 2377 17 were be VBD cord-015306-us58wwmp 2377 18 uncorrelated uncorrelated JJ cord-015306-us58wwmp 2377 19 with with IN cord-015306-us58wwmp 2377 20 proteinuria proteinuria NN cord-015306-us58wwmp 2377 21 . . . cord-015306-us58wwmp 2378 1 Conclusion conclusion NN cord-015306-us58wwmp 2378 2 : : : cord-015306-us58wwmp 2378 3 Blood blood NN cord-015306-us58wwmp 2378 4 , , , cord-015306-us58wwmp 2378 5 urine urine NN cord-015306-us58wwmp 2378 6 and and CC cord-015306-us58wwmp 2378 7 renal renal JJ cord-015306-us58wwmp 2378 8 NGAL NGAL NNP cord-015306-us58wwmp 2378 9 and and CC cord-015306-us58wwmp 2378 10 KIM-1 KIM-1 NNP cord-015306-us58wwmp 2378 11 were be VBD cord-015306-us58wwmp 2378 12 significantly significantly RB cord-015306-us58wwmp 2378 13 increased increase VBN cord-015306-us58wwmp 2378 14 in in IN cord-015306-us58wwmp 2378 15 patients patient NNS cord-015306-us58wwmp 2378 16 with with IN cord-015306-us58wwmp 2378 17 A a DT cord-015306-us58wwmp 2378 18 - - HYPH cord-015306-us58wwmp 2378 19 on on IN cord-015306-us58wwmp 2378 20 - - HYPH cord-015306-us58wwmp 2378 21 C c NN cord-015306-us58wwmp 2378 22 than than IN cord-015306-us58wwmp 2378 23 those those DT cord-015306-us58wwmp 2378 24 with with IN cord-015306-us58wwmp 2378 25 HSPN HSPN NNP cord-015306-us58wwmp 2378 26 , , , cord-015306-us58wwmp 2378 27 and and CC cord-015306-us58wwmp 2378 28 they -PRON- PRP cord-015306-us58wwmp 2378 29 were be VBD cord-015306-us58wwmp 2378 30 negative negative JJ cord-015306-us58wwmp 2378 31 correlated correlate VBN cord-015306-us58wwmp 2378 32 with with IN cord-015306-us58wwmp 2378 33 GFR GFR NNP cord-015306-us58wwmp 2378 34 . . . cord-015306-us58wwmp 2379 1 We -PRON- PRP cord-015306-us58wwmp 2379 2 may may MD cord-015306-us58wwmp 2379 3 conclude conclude VB cord-015306-us58wwmp 2379 4 that that IN cord-015306-us58wwmp 2379 5 NGAL NGAL NNP cord-015306-us58wwmp 2379 6 and and CC cord-015306-us58wwmp 2379 7 KIM-1 KIM-1 NNP cord-015306-us58wwmp 2379 8 may may MD cord-015306-us58wwmp 2379 9 diagnose diagnose VB cord-015306-us58wwmp 2379 10 A A NNP cord-015306-us58wwmp 2379 11 - - HYPH cord-015306-us58wwmp 2379 12 on on IN cord-015306-us58wwmp 2379 13 - - HYPH cord-015306-us58wwmp 2379 14 C c NN cord-015306-us58wwmp 2379 15 patients patient NNS cord-015306-us58wwmp 2379 16 more more RBR cord-015306-us58wwmp 2379 17 sensitive sensitive JJ cord-015306-us58wwmp 2379 18 than than IN cord-015306-us58wwmp 2379 19 SCr SCr NNS cord-015306-us58wwmp 2379 20 . . . cord-015306-us58wwmp 2380 1 Abstract abstract JJ cord-015306-us58wwmp 2380 2 # # NN cord-015306-us58wwmp 2380 3 P p NN cord-015306-us58wwmp 2380 4 - - HYPH cord-015306-us58wwmp 2380 5 SAT300 SAT300 NNP cord-015306-us58wwmp 2380 6 Objective Objective NNP cord-015306-us58wwmp 2380 7 : : : cord-015306-us58wwmp 2380 8 Neonatal neonatal JJ cord-015306-us58wwmp 2380 9 period period NN cord-015306-us58wwmp 2380 10 is be VBZ cord-015306-us58wwmp 2380 11 an an DT cord-015306-us58wwmp 2380 12 important important JJ cord-015306-us58wwmp 2380 13 stage stage NN cord-015306-us58wwmp 2380 14 in in IN cord-015306-us58wwmp 2380 15 the the DT cord-015306-us58wwmp 2380 16 development development NN cord-015306-us58wwmp 2380 17 of of IN cord-015306-us58wwmp 2380 18 renal renal JJ cord-015306-us58wwmp 2380 19 function function NN cord-015306-us58wwmp 2380 20 at at IN cord-015306-us58wwmp 2380 21 the the DT cord-015306-us58wwmp 2380 22 children child NNS cord-015306-us58wwmp 2380 23 . . . cord-015306-us58wwmp 2381 1 The the DT cord-015306-us58wwmp 2381 2 frequency frequency NN cord-015306-us58wwmp 2381 3 of of IN cord-015306-us58wwmp 2381 4 renal renal JJ cord-015306-us58wwmp 2381 5 damage damage NN cord-015306-us58wwmp 2381 6 in in IN cord-015306-us58wwmp 2381 7 infants infant NNS cord-015306-us58wwmp 2381 8 undergoing undergo VBG cord-015306-us58wwmp 2381 9 resuscitation resuscitation NN cord-015306-us58wwmp 2381 10 is be VBZ cord-015306-us58wwmp 2381 11 high high JJ cord-015306-us58wwmp 2381 12 , , , cord-015306-us58wwmp 2381 13 but but CC cord-015306-us58wwmp 2381 14 non non JJ cord-015306-us58wwmp 2381 15 - - JJ cord-015306-us58wwmp 2381 16 specific specific JJ cord-015306-us58wwmp 2381 17 clinical clinical JJ cord-015306-us58wwmp 2381 18 symptoms symptom NNS cord-015306-us58wwmp 2381 19 and and CC cord-015306-us58wwmp 2381 20 low low JJ cord-015306-us58wwmp 2381 21 information information NN cord-015306-us58wwmp 2381 22 existing exist VBG cord-015306-us58wwmp 2381 23 survey survey NN cord-015306-us58wwmp 2381 24 methods method NNS cord-015306-us58wwmp 2381 25 impede impede VBP cord-015306-us58wwmp 2381 26 their -PRON- PRP$ cord-015306-us58wwmp 2381 27 timely timely JJ cord-015306-us58wwmp 2381 28 diagnosis diagnosis NN cord-015306-us58wwmp 2381 29 . . . cord-015306-us58wwmp 2382 1 Purpose purpose NN cord-015306-us58wwmp 2382 2 -evaluation -evaluation NN cord-015306-us58wwmp 2382 3 of of IN cord-015306-us58wwmp 2382 4 diagnostic diagnostic JJ cord-015306-us58wwmp 2382 5 importance importance NN cord-015306-us58wwmp 2382 6 of of IN cord-015306-us58wwmp 2382 7 determining determine VBG cord-015306-us58wwmp 2382 8 the the DT cord-015306-us58wwmp 2382 9 level level NN cord-015306-us58wwmp 2382 10 of of IN cord-015306-us58wwmp 2382 11 carbonic carbonic JJ cord-015306-us58wwmp 2382 12 anhydrase anhydrase NN cord-015306-us58wwmp 2382 13 IX IX NNP cord-015306-us58wwmp 2382 14 ( ( -LRB- cord-015306-us58wwmp 2382 15 CA9 CA9 NNP cord-015306-us58wwmp 2382 16 ) ) -RRB- cord-015306-us58wwmp 2382 17 in in IN cord-015306-us58wwmp 2382 18 the the DT cord-015306-us58wwmp 2382 19 urine urine NN cord-015306-us58wwmp 2382 20 of of IN cord-015306-us58wwmp 2382 21 newborns newborn NNS cord-015306-us58wwmp 2382 22 in in IN cord-015306-us58wwmp 2382 23 critical critical JJ cord-015306-us58wwmp 2382 24 states state NNS cord-015306-us58wwmp 2382 25 . . . cord-015306-us58wwmp 2383 1 Methods method NNS cord-015306-us58wwmp 2383 2 : : : cord-015306-us58wwmp 2384 1 We -PRON- PRP cord-015306-us58wwmp 2384 2 evaluated evaluate VBD cord-015306-us58wwmp 2384 3 Human human JJ cord-015306-us58wwmp 2384 4 carbonic carbonic JJ cord-015306-us58wwmp 2384 5 anhydrase anhydrase NN cord-015306-us58wwmp 2384 6 IX IX NNP cord-015306-us58wwmp 2384 7 in in IN cord-015306-us58wwmp 2384 8 the the DT cord-015306-us58wwmp 2384 9 urine urine NN cord-015306-us58wwmp 2384 10 of of IN cord-015306-us58wwmp 2384 11 40 40 CD cord-015306-us58wwmp 2384 12 newborns newborn NNS cord-015306-us58wwmp 2384 13 who who WP cord-015306-us58wwmp 2384 14 had have VBD cord-015306-us58wwmp 2384 15 asphyxia asphyxia NN cord-015306-us58wwmp 2384 16 at at IN cord-015306-us58wwmp 2384 17 birth birth NN cord-015306-us58wwmp 2384 18 and and CC cord-015306-us58wwmp 2384 19 receiving receive VBG cord-015306-us58wwmp 2384 20 treatment treatment NN cord-015306-us58wwmp 2384 21 in in IN cord-015306-us58wwmp 2384 22 the the DT cord-015306-us58wwmp 2384 23 intensive intensive JJ cord-015306-us58wwmp 2384 24 care care NN cord-015306-us58wwmp 2384 25 unit unit NN cord-015306-us58wwmp 2384 26 -the -the DT cord-015306-us58wwmp 2384 27 main main JJ cord-015306-us58wwmp 2384 28 group group NN cord-015306-us58wwmp 2384 29 . . . cord-015306-us58wwmp 2385 1 The the DT cord-015306-us58wwmp 2385 2 control control NN cord-015306-us58wwmp 2385 3 group group NN cord-015306-us58wwmp 2385 4 consisted consist VBD cord-015306-us58wwmp 2385 5 from from IN cord-015306-us58wwmp 2385 6 healthy healthy JJ cord-015306-us58wwmp 2385 7 newborns newborn NNS cord-015306-us58wwmp 2385 8 ( ( -LRB- cord-015306-us58wwmp 2385 9 13 13 CD cord-015306-us58wwmp 2385 10 people people NNS cord-015306-us58wwmp 2385 11 ) ) -RRB- cord-015306-us58wwmp 2385 12 . . . cord-015306-us58wwmp 2386 1 For for IN cord-015306-us58wwmp 2386 2 the the DT cord-015306-us58wwmp 2386 3 study study NN cord-015306-us58wwmp 2386 4 used use VBD cord-015306-us58wwmp 2386 5 a a DT cord-015306-us58wwmp 2386 6 sample sample NN cord-015306-us58wwmp 2386 7 of of IN cord-015306-us58wwmp 2386 8 newborn newborn JJ cord-015306-us58wwmp 2386 9 urine urine NN cord-015306-us58wwmp 2386 10 collected collect VBN cord-015306-us58wwmp 2386 11 at at IN cord-015306-us58wwmp 2386 12 1 1 CD cord-015306-us58wwmp 2386 13 - - SYM cord-015306-us58wwmp 2386 14 2 2 CD cord-015306-us58wwmp 2386 15 days day NNS cord-015306-us58wwmp 2386 16 of of IN cord-015306-us58wwmp 2386 17 age age NN cord-015306-us58wwmp 2386 18 . . . cord-015306-us58wwmp 2387 1 Carbonic carbonic JJ cord-015306-us58wwmp 2387 2 anhydrase anhydrase NN cord-015306-us58wwmp 2387 3 was be VBD cord-015306-us58wwmp 2387 4 determined determine VBN cord-015306-us58wwmp 2387 5 using use VBG cord-015306-us58wwmp 2387 6 enzyme enzyme NN cord-015306-us58wwmp 2387 7 immunoassay immunoassay JJ cord-015306-us58wwmp 2387 8 kit kit NN cord-015306-us58wwmp 2387 9 . . . cord-015306-us58wwmp 2388 1 Results result NNS cord-015306-us58wwmp 2388 2 : : : cord-015306-us58wwmp 2389 1 Human human JJ cord-015306-us58wwmp 2389 2 carbonic carbonic JJ cord-015306-us58wwmp 2389 3 anhydrase anhydrase NN cord-015306-us58wwmp 2389 4 IX IX NNP cord-015306-us58wwmp 2390 1 ( ( -LRB- cord-015306-us58wwmp 2390 2 CA9 CA9 NNP cord-015306-us58wwmp 2390 3 ) ) -RRB- cord-015306-us58wwmp 2390 4 -trans -trans . cord-015306-us58wwmp 2391 1 membrane membrane NN cord-015306-us58wwmp 2391 2 protein protein NN cord-015306-us58wwmp 2391 3 , , , cord-015306-us58wwmp 2391 4 the the DT cord-015306-us58wwmp 2391 5 main main JJ cord-015306-us58wwmp 2391 6 physiological physiological JJ cord-015306-us58wwmp 2391 7 function function NN cord-015306-us58wwmp 2391 8 of of IN cord-015306-us58wwmp 2391 9 which which WDT cord-015306-us58wwmp 2391 10 is be VBZ cord-015306-us58wwmp 2391 11 to to TO cord-015306-us58wwmp 2391 12 regulate regulate VB cord-015306-us58wwmp 2391 13 the the DT cord-015306-us58wwmp 2391 14 pH ph NN cord-015306-us58wwmp 2391 15 by by IN cord-015306-us58wwmp 2391 16 the the DT cord-015306-us58wwmp 2391 17 reversible reversible JJ cord-015306-us58wwmp 2391 18 hydration hydration NN cord-015306-us58wwmp 2391 19 of of IN cord-015306-us58wwmp 2391 20 carbon carbon NN cord-015306-us58wwmp 2391 21 dioxide dioxide NN cord-015306-us58wwmp 2391 22 . . . cord-015306-us58wwmp 2392 1 The the DT cord-015306-us58wwmp 2392 2 main main JJ cord-015306-us58wwmp 2392 3 pathogenic pathogenic JJ cord-015306-us58wwmp 2392 4 factor factor NN cord-015306-us58wwmp 2392 5 causing cause VBG cord-015306-us58wwmp 2392 6 kidney kidney NN cord-015306-us58wwmp 2392 7 damage damage NN cord-015306-us58wwmp 2392 8 of of IN cord-015306-us58wwmp 2392 9 fetus fetus NN cord-015306-us58wwmp 2392 10 is be VBZ cord-015306-us58wwmp 2392 11 chronic chronic JJ cord-015306-us58wwmp 2392 12 fetal fetal JJ cord-015306-us58wwmp 2392 13 hypoxia hypoxia NN cord-015306-us58wwmp 2392 14 . . . cord-015306-us58wwmp 2393 1 There there EX cord-015306-us58wwmp 2393 2 is be VBZ cord-015306-us58wwmp 2393 3 a a DT cord-015306-us58wwmp 2393 4 single single JJ cord-015306-us58wwmp 2393 5 study study NN cord-015306-us58wwmp 2393 6 HIF HIF NNP cord-015306-us58wwmp 2393 7 - - HYPH cord-015306-us58wwmp 2393 8 I -PRON- PRP cord-015306-us58wwmp 2393 9 alpha alpha NN cord-015306-us58wwmp 2393 10 ( ( -LRB- cord-015306-us58wwmp 2393 11 hypoxia hypoxia VB cord-015306-us58wwmp 2393 12 inducible inducible JJ cord-015306-us58wwmp 2393 13 factor factor NN cord-015306-us58wwmp 2393 14 - - : cord-015306-us58wwmp 2393 15 I -PRON- PRP cord-015306-us58wwmp 2393 16 alpha alpha NN cord-015306-us58wwmp 2393 17 ) ) -RRB- cord-015306-us58wwmp 2393 18 in in IN cord-015306-us58wwmp 2393 19 the the DT cord-015306-us58wwmp 2393 20 blood blood NN cord-015306-us58wwmp 2393 21 , , , cord-015306-us58wwmp 2393 22 increased increase VBN cord-015306-us58wwmp 2393 23 expression expression NN cord-015306-us58wwmp 2393 24 of of IN cord-015306-us58wwmp 2393 25 which which WDT cord-015306-us58wwmp 2393 26 occurs occur VBZ cord-015306-us58wwmp 2393 27 during during IN cord-015306-us58wwmp 2393 28 hypoxia hypoxia NN cord-015306-us58wwmp 2393 29 . . . cord-015306-us58wwmp 2394 1 This this DT cord-015306-us58wwmp 2394 2 is be VBZ cord-015306-us58wwmp 2394 3 connected connect VBN cord-015306-us58wwmp 2394 4 with with IN cord-015306-us58wwmp 2394 5 damage damage NN cord-015306-us58wwmp 2394 6 of of IN cord-015306-us58wwmp 2394 7 tubules tubule NNS cord-015306-us58wwmp 2394 8 and and CC cord-015306-us58wwmp 2394 9 interstitial interstitial JJ cord-015306-us58wwmp 2394 10 cells cell NNS cord-015306-us58wwmp 2394 11 of of IN cord-015306-us58wwmp 2394 12 the the DT cord-015306-us58wwmp 2394 13 kidneys kidney NNS cord-015306-us58wwmp 2394 14 , , , cord-015306-us58wwmp 2394 15 their -PRON- PRP$ cord-015306-us58wwmp 2394 16 proliferation proliferation NN cord-015306-us58wwmp 2394 17 , , , cord-015306-us58wwmp 2394 18 synthesis synthesis NN cord-015306-us58wwmp 2394 19 of of IN cord-015306-us58wwmp 2394 20 cytokines cytokine NNS cord-015306-us58wwmp 2394 21 and and CC cord-015306-us58wwmp 2394 22 extracellular extracellular JJ cord-015306-us58wwmp 2394 23 matrix matrix NN cord-015306-us58wwmp 2394 24 . . . cord-015306-us58wwmp 2395 1 In in IN cord-015306-us58wwmp 2395 2 this this DT cord-015306-us58wwmp 2395 3 case case NN cord-015306-us58wwmp 2395 4 , , , cord-015306-us58wwmp 2395 5 activity activity NN cord-015306-us58wwmp 2395 6 of of IN cord-015306-us58wwmp 2395 7 CA9 CA9 NNP cord-015306-us58wwmp 2395 8 is be VBZ cord-015306-us58wwmp 2395 9 reduced reduce VBN cord-015306-us58wwmp 2395 10 in in IN cord-015306-us58wwmp 2395 11 the the DT cord-015306-us58wwmp 2395 12 blood blood NN cord-015306-us58wwmp 2395 13 . . . cord-015306-us58wwmp 2396 1 Normally normally RB cord-015306-us58wwmp 2396 2 , , , cord-015306-us58wwmp 2396 3 CA9 CA9 NNP cord-015306-us58wwmp 2396 4 is be VBZ cord-015306-us58wwmp 2396 5 missing miss VBG cord-015306-us58wwmp 2396 6 in in IN cord-015306-us58wwmp 2396 7 the the DT cord-015306-us58wwmp 2396 8 urine urine NN cord-015306-us58wwmp 2396 9 , , , cord-015306-us58wwmp 2396 10 so so IN cord-015306-us58wwmp 2396 11 its -PRON- PRP$ cord-015306-us58wwmp 2396 12 definition definition NN cord-015306-us58wwmp 2396 13 can can MD cord-015306-us58wwmp 2396 14 be be VB cord-015306-us58wwmp 2396 15 a a DT cord-015306-us58wwmp 2396 16 marker marker NN cord-015306-us58wwmp 2396 17 of of IN cord-015306-us58wwmp 2396 18 early early JJ cord-015306-us58wwmp 2396 19 renal renal JJ cord-015306-us58wwmp 2396 20 dysfunction dysfunction NN cord-015306-us58wwmp 2396 21 . . . cord-015306-us58wwmp 2397 1 The the DT cord-015306-us58wwmp 2397 2 authentic authentic JJ cord-015306-us58wwmp 2397 3 increase increase NN cord-015306-us58wwmp 2397 4 of of IN cord-015306-us58wwmp 2397 5 CA9 ca9 JJ cord-015306-us58wwmp 2397 6 level level NN cord-015306-us58wwmp 2397 7 in in IN cord-015306-us58wwmp 2397 8 the the DT cord-015306-us58wwmp 2397 9 main main JJ cord-015306-us58wwmp 2397 10 group group NN cord-015306-us58wwmp 2397 11 was be VBD cord-015306-us58wwmp 2397 12 revealed reveal VBN cord-015306-us58wwmp 2397 13 in in IN cord-015306-us58wwmp 2397 14 comparison comparison NN cord-015306-us58wwmp 2397 15 with with IN cord-015306-us58wwmp 2397 16 the the DT cord-015306-us58wwmp 2397 17 control control NN cord-015306-us58wwmp 2397 18 group group NN cord-015306-us58wwmp 2397 19 ( ( -LRB- cord-015306-us58wwmp 2397 20 and and CC cord-015306-us58wwmp 2397 21 β2-MG β2-MG NNP cord-015306-us58wwmp 2397 22 , , , cord-015306-us58wwmp 2397 23 59,723/ 59,723/ NNP cord-015306-us58wwmp 2397 24 32,616/ 32,616/ CD cord-015306-us58wwmp 2397 25 1511/ 1511/ CD cord-015306-us58wwmp 2397 26 996/ 996/ CD cord-015306-us58wwmp 2397 27 1084/ 1084/ CD cord-015306-us58wwmp 2397 28 600 600 CD cord-015306-us58wwmp 2397 29 μg/ μg/ XX cord-015306-us58wwmp 2398 1 g g NNP cord-015306-us58wwmp 2398 2 Cr Cr NNP cord-015306-us58wwmp 2398 3 . . . cord-015306-us58wwmp 2399 1 Levels level NNS cord-015306-us58wwmp 2399 2 of of IN cord-015306-us58wwmp 2399 3 each each DT cord-015306-us58wwmp 2399 4 marker marker NN cord-015306-us58wwmp 2399 5 were be VBD cord-015306-us58wwmp 2399 6 very very RB cord-015306-us58wwmp 2399 7 high high JJ cord-015306-us58wwmp 2399 8 in in IN cord-015306-us58wwmp 2399 9 NB NB NNP cord-015306-us58wwmp 2399 10 and and CC cord-015306-us58wwmp 2399 11 1 1 CD cord-015306-us58wwmp 2399 12 M M NNP cord-015306-us58wwmp 2399 13 children child NNS cord-015306-us58wwmp 2399 14 , , , cord-015306-us58wwmp 2399 15 and and CC cord-015306-us58wwmp 2399 16 subsequently subsequently RB cord-015306-us58wwmp 2399 17 decreased decrease VBD cord-015306-us58wwmp 2399 18 gradually gradually RB cord-015306-us58wwmp 2399 19 . . . cord-015306-us58wwmp 2400 1 Urinary urinary JJ cord-015306-us58wwmp 2400 2 α1-MG α1-MG NNPS cord-015306-us58wwmp 2400 3 levels level NNS cord-015306-us58wwmp 2400 4 reduced reduce VBD cord-015306-us58wwmp 2400 5 the the DT cord-015306-us58wwmp 2400 6 quickest quick JJS cord-015306-us58wwmp 2400 7 , , , cord-015306-us58wwmp 2400 8 and and CC cord-015306-us58wwmp 2400 9 became become VBD cord-015306-us58wwmp 2400 10 the the DT cord-015306-us58wwmp 2400 11 same same JJ cord-015306-us58wwmp 2400 12 as as IN cord-015306-us58wwmp 2400 13 at at IN cord-015306-us58wwmp 2400 14 > > XX cord-015306-us58wwmp 2400 15 =3 =3 NN cord-015306-us58wwmp 2400 16 years year NNS cord-015306-us58wwmp 2400 17 old old JJ cord-015306-us58wwmp 2400 18 by by IN cord-015306-us58wwmp 2400 19 6 6 CD cord-015306-us58wwmp 2400 20 months month NNS cord-015306-us58wwmp 2400 21 after after IN cord-015306-us58wwmp 2400 22 birth birth NN cord-015306-us58wwmp 2400 23 . . . cord-015306-us58wwmp 2401 1 Conclusion conclusion NN cord-015306-us58wwmp 2401 2 : : : cord-015306-us58wwmp 2402 1 Renal renal JJ cord-015306-us58wwmp 2402 2 tubular tubular JJ cord-015306-us58wwmp 2402 3 function function NN cord-015306-us58wwmp 2402 4 can can MD cord-015306-us58wwmp 2402 5 be be VB cord-015306-us58wwmp 2402 6 evaluated evaluate VBN cord-015306-us58wwmp 2402 7 in in IN cord-015306-us58wwmp 2402 8 children child NNS cord-015306-us58wwmp 2402 9 <3 <3 . cord-015306-us58wwmp 2402 10 years year NNS cord-015306-us58wwmp 2402 11 old old JJ cord-015306-us58wwmp 2402 12 using use VBG cord-015306-us58wwmp 2402 13 these these DT cord-015306-us58wwmp 2402 14 normal normal JJ cord-015306-us58wwmp 2402 15 values value NNS cord-015306-us58wwmp 2402 16 . . . cord-015306-us58wwmp 2403 1 The the DT cord-015306-us58wwmp 2403 2 most most RBS cord-015306-us58wwmp 2403 3 stable stable JJ cord-015306-us58wwmp 2403 4 and and CC cord-015306-us58wwmp 2403 5 useful useful JJ cord-015306-us58wwmp 2403 6 marker marker NN cord-015306-us58wwmp 2403 7 from from IN cord-015306-us58wwmp 2403 8 early early JJ cord-015306-us58wwmp 2403 9 infancy infancy NN cord-015306-us58wwmp 2403 10 seems seem VBZ cord-015306-us58wwmp 2403 11 to to TO cord-015306-us58wwmp 2403 12 be be VB cord-015306-us58wwmp 2403 13 urinary urinary JJ cord-015306-us58wwmp 2403 14 α1-MG α1-MG NNS cord-015306-us58wwmp 2403 15 . . . cord-015306-us58wwmp 2404 1 Urinary urinary JJ cord-015306-us58wwmp 2404 2 biomarkers biomarker NNS cord-015306-us58wwmp 2404 3 for for IN cord-015306-us58wwmp 2404 4 gentamicin gentamicin NN cord-015306-us58wwmp 2404 5 - - HYPH cord-015306-us58wwmp 2404 6 induced induce VBN cord-015306-us58wwmp 2404 7 acute acute JJ cord-015306-us58wwmp 2404 8 kidney kidney NN cord-015306-us58wwmp 2404 9 injury injury NN cord-015306-us58wwmp 2404 10 in in IN cord-015306-us58wwmp 2404 11 the the DT cord-015306-us58wwmp 2404 12 neonatal neonatal JJ cord-015306-us58wwmp 2404 13 intensive intensive JJ cord-015306-us58wwmp 2404 14 care care NN cord-015306-us58wwmp 2404 15 unit unit NN cord-015306-us58wwmp 2405 1 Objective objective JJ cord-015306-us58wwmp 2405 2 : : : cord-015306-us58wwmp 2405 3 Gentamicin Gentamicin NNP cord-015306-us58wwmp 2405 4 ( ( -LRB- cord-015306-us58wwmp 2405 5 GM GM NNP cord-015306-us58wwmp 2405 6 ) ) -RRB- cord-015306-us58wwmp 2405 7 is be VBZ cord-015306-us58wwmp 2405 8 an an DT cord-015306-us58wwmp 2405 9 aminoglycoside aminoglycoside NN cord-015306-us58wwmp 2405 10 frequently frequently RB cord-015306-us58wwmp 2405 11 used use VBN cord-015306-us58wwmp 2405 12 in in IN cord-015306-us58wwmp 2405 13 the the DT cord-015306-us58wwmp 2405 14 neonatal neonatal JJ cord-015306-us58wwmp 2405 15 intensive intensive JJ cord-015306-us58wwmp 2405 16 care care NN cord-015306-us58wwmp 2405 17 unit unit NN cord-015306-us58wwmp 2405 18 ( ( -LRB- cord-015306-us58wwmp 2405 19 NICU NICU NNP cord-015306-us58wwmp 2405 20 ) ) -RRB- cord-015306-us58wwmp 2405 21 . . . cord-015306-us58wwmp 2406 1 GM GM NNP cord-015306-us58wwmp 2406 2 is be VBZ cord-015306-us58wwmp 2406 3 nephrotoxic nephrotoxic JJ cord-015306-us58wwmp 2406 4 and and CC cord-015306-us58wwmp 2406 5 may may MD cord-015306-us58wwmp 2406 6 cause cause VB cord-015306-us58wwmp 2406 7 acute acute JJ cord-015306-us58wwmp 2406 8 kidney kidney NN cord-015306-us58wwmp 2406 9 injury injury NN cord-015306-us58wwmp 2406 10 ( ( -LRB- cord-015306-us58wwmp 2406 11 AKI AKI NNP cord-015306-us58wwmp 2406 12 ) ) -RRB- cord-015306-us58wwmp 2406 13 . . . cord-015306-us58wwmp 2407 1 Serum serum NN cord-015306-us58wwmp 2407 2 creatinine creatinine NN cord-015306-us58wwmp 2407 3 ( ( -LRB- cord-015306-us58wwmp 2407 4 sCr scr NN cord-015306-us58wwmp 2407 5 ) ) -RRB- cord-015306-us58wwmp 2407 6 appears appear VBZ cord-015306-us58wwmp 2407 7 to to TO cord-015306-us58wwmp 2407 8 be be VB cord-015306-us58wwmp 2407 9 an an DT cord-015306-us58wwmp 2407 10 insensitive insensitive JJ cord-015306-us58wwmp 2407 11 and and CC cord-015306-us58wwmp 2407 12 unreliable unreliable JJ cord-015306-us58wwmp 2407 13 marker marker NN cord-015306-us58wwmp 2407 14 for for IN cord-015306-us58wwmp 2407 15 detecting detect VBG cord-015306-us58wwmp 2407 16 AKI AKI NNP cord-015306-us58wwmp 2407 17 . . . cord-015306-us58wwmp 2408 1 To to TO cord-015306-us58wwmp 2408 2 determine determine VB cord-015306-us58wwmp 2408 3 whether whether IN cord-015306-us58wwmp 2408 4 urine urine NN cord-015306-us58wwmp 2408 5 biomarkers biomarker NNS cord-015306-us58wwmp 2408 6 are be VBP cord-015306-us58wwmp 2408 7 useful useful JJ cord-015306-us58wwmp 2408 8 for for IN cord-015306-us58wwmp 2408 9 early early JJ cord-015306-us58wwmp 2408 10 detection detection NN cord-015306-us58wwmp 2408 11 of of IN cord-015306-us58wwmp 2408 12 GM GM NNP cord-015306-us58wwmp 2408 13 - - HYPH cord-015306-us58wwmp 2408 14 induced induce VBN cord-015306-us58wwmp 2408 15 AKI AKI NNP cord-015306-us58wwmp 2408 16 in in IN cord-015306-us58wwmp 2408 17 neonates neonate NNS cord-015306-us58wwmp 2408 18 in in IN cord-015306-us58wwmp 2408 19 the the DT cord-015306-us58wwmp 2408 20 NICU NICU NNP cord-015306-us58wwmp 2408 21 . . . cord-015306-us58wwmp 2409 1 Methods method NNS cord-015306-us58wwmp 2409 2 : : : cord-015306-us58wwmp 2409 3 Prospective prospective JJ cord-015306-us58wwmp 2409 4 , , , cord-015306-us58wwmp 2409 5 clinical clinical JJ cord-015306-us58wwmp 2409 6 , , , cord-015306-us58wwmp 2409 7 observational observational JJ cord-015306-us58wwmp 2409 8 study study NN cord-015306-us58wwmp 2409 9 . . . cord-015306-us58wwmp 2410 1 Forty forty CD cord-015306-us58wwmp 2410 2 - - HYPH cord-015306-us58wwmp 2410 3 six six CD cord-015306-us58wwmp 2410 4 neonates neonate NNS cord-015306-us58wwmp 2410 5 ( ( -LRB- cord-015306-us58wwmp 2410 6 32M/14F 32m/14f LS cord-015306-us58wwmp 2410 7 ) ) -RRB- cord-015306-us58wwmp 2410 8 without without IN cord-015306-us58wwmp 2410 9 pre pre JJ cord-015306-us58wwmp 2410 10 - - JJ cord-015306-us58wwmp 2410 11 existent existent JJ cord-015306-us58wwmp 2410 12 kidney kidney NN cord-015306-us58wwmp 2410 13 disease disease NN cord-015306-us58wwmp 2410 14 were be VBD cord-015306-us58wwmp 2410 15 divided divide VBN cord-015306-us58wwmp 2410 16 in in IN cord-015306-us58wwmp 2410 17 a a DT cord-015306-us58wwmp 2410 18 GM GM NNP cord-015306-us58wwmp 2410 19 group group NN cord-015306-us58wwmp 2410 20 ( ( -LRB- cord-015306-us58wwmp 2410 21 n=26 n=26 RB cord-015306-us58wwmp 2410 22 ) ) -RRB- cord-015306-us58wwmp 2410 23 and and CC cord-015306-us58wwmp 2410 24 a a DT cord-015306-us58wwmp 2410 25 reference reference NN cord-015306-us58wwmp 2410 26 group group NN cord-015306-us58wwmp 2410 27 ( ( -LRB- cord-015306-us58wwmp 2410 28 n=20 n=20 NNP cord-015306-us58wwmp 2410 29 ) ) -RRB- cord-015306-us58wwmp 2410 30 . . . cord-015306-us58wwmp 2411 1 Demographics demographic NNS cord-015306-us58wwmp 2411 2 , , , cord-015306-us58wwmp 2411 3 vital vital JJ cord-015306-us58wwmp 2411 4 signs sign NNS cord-015306-us58wwmp 2411 5 and and CC cord-015306-us58wwmp 2411 6 clinical clinical JJ cord-015306-us58wwmp 2411 7 conditions condition NNS cord-015306-us58wwmp 2411 8 were be VBD cord-015306-us58wwmp 2411 9 recorded record VBN cord-015306-us58wwmp 2411 10 . . . cord-015306-us58wwmp 2412 1 Only only RB cord-015306-us58wwmp 2412 2 neonates neonate NNS cord-015306-us58wwmp 2412 3 with with IN cord-015306-us58wwmp 2412 4 a a DT cord-015306-us58wwmp 2412 5 bladder bladder NN cord-015306-us58wwmp 2412 6 catheter catheter NN cord-015306-us58wwmp 2412 7 in in IN cord-015306-us58wwmp 2412 8 place place NN cord-015306-us58wwmp 2412 9 were be VBD cord-015306-us58wwmp 2412 10 included include VBN cord-015306-us58wwmp 2412 11 . . . cord-015306-us58wwmp 2413 1 Urine urine NN cord-015306-us58wwmp 2413 2 samples sample NNS cord-015306-us58wwmp 2413 3 were be VBD cord-015306-us58wwmp 2413 4 collected collect VBN cord-015306-us58wwmp 2413 5 every every DT cord-015306-us58wwmp 2413 6 two two CD cord-015306-us58wwmp 2413 7 hours hour NNS cord-015306-us58wwmp 2413 8 . . . cord-015306-us58wwmp 2414 1 Biomarkers biomarker NNS cord-015306-us58wwmp 2414 2 ( ( -LRB- cord-015306-us58wwmp 2414 3 GSTA1 GSTA1 NNP cord-015306-us58wwmp 2414 4 - - HYPH cord-015306-us58wwmp 2414 5 1 1 CD cord-015306-us58wwmp 2414 6 , , , cord-015306-us58wwmp 2414 7 GSTP1 GSTP1 NNP cord-015306-us58wwmp 2414 8 - - HYPH cord-015306-us58wwmp 2414 9 1 1 CD cord-015306-us58wwmp 2414 10 , , , cord-015306-us58wwmp 2414 11 KIM-1 KIM-1 NNP cord-015306-us58wwmp 2414 12 , , , cord-015306-us58wwmp 2414 13 NAG NAG NNP cord-015306-us58wwmp 2414 14 , , , cord-015306-us58wwmp 2414 15 NGAL NGAL NNP cord-015306-us58wwmp 2414 16 ) ) -RRB- cord-015306-us58wwmp 2414 17 were be VBD cord-015306-us58wwmp 2414 18 determined determine VBN cord-015306-us58wwmp 2414 19 . . . cord-015306-us58wwmp 2415 1 Residual residual JJ cord-015306-us58wwmp 2415 2 blood blood NN cord-015306-us58wwmp 2415 3 samples sample NNS cord-015306-us58wwmp 2415 4 were be VBD cord-015306-us58wwmp 2415 5 used use VBN cord-015306-us58wwmp 2415 6 to to TO cord-015306-us58wwmp 2415 7 measure measure VB cord-015306-us58wwmp 2415 8 sCr sCr NNS cord-015306-us58wwmp 2415 9 . . . cord-015306-us58wwmp 2416 1 Results result NNS cord-015306-us58wwmp 2416 2 : : : cord-015306-us58wwmp 2417 1 The the DT cord-015306-us58wwmp 2417 2 GM GM NNP cord-015306-us58wwmp 2417 3 and and CC cord-015306-us58wwmp 2417 4 reference reference NN cord-015306-us58wwmp 2417 5 group group NN cord-015306-us58wwmp 2417 6 were be VBD cord-015306-us58wwmp 2417 7 comparable comparable JJ cord-015306-us58wwmp 2417 8 for for IN cord-015306-us58wwmp 2417 9 gestational gestational JJ cord-015306-us58wwmp 2417 10 age age NN cord-015306-us58wwmp 2417 11 , , , cord-015306-us58wwmp 2417 12 weight weight NN cord-015306-us58wwmp 2417 13 and and CC cord-015306-us58wwmp 2417 14 mortality mortality NN cord-015306-us58wwmp 2417 15 . . . cord-015306-us58wwmp 2418 1 Neonates neonate NNS cord-015306-us58wwmp 2418 2 treated treat VBN cord-015306-us58wwmp 2418 3 with with IN cord-015306-us58wwmp 2418 4 GM GM NNP cord-015306-us58wwmp 2418 5 are be VBP cord-015306-us58wwmp 2418 6 admitted admit VBN cord-015306-us58wwmp 2418 7 longer long RBR cord-015306-us58wwmp 2418 8 than than IN cord-015306-us58wwmp 2418 9 neonates neonate NNS cord-015306-us58wwmp 2418 10 in in IN cord-015306-us58wwmp 2418 11 the the DT cord-015306-us58wwmp 2418 12 reference reference NN cord-015306-us58wwmp 2418 13 group group NN cord-015306-us58wwmp 2418 14 . . . cord-015306-us58wwmp 2419 1 Treatment treatment NN cord-015306-us58wwmp 2419 2 with with IN cord-015306-us58wwmp 2419 3 GM GM NNP cord-015306-us58wwmp 2419 4 resulted result VBD cord-015306-us58wwmp 2419 5 in in IN cord-015306-us58wwmp 2419 6 higher high JJR cord-015306-us58wwmp 2419 7 sCr sCr NNS cord-015306-us58wwmp 2419 8 compared compare VBN cord-015306-us58wwmp 2419 9 to to IN cord-015306-us58wwmp 2419 10 the the DT cord-015306-us58wwmp 2419 11 reference reference NN cord-015306-us58wwmp 2419 12 group group NN cord-015306-us58wwmp 2419 13 ( ( -LRB- cord-015306-us58wwmp 2419 14 58 58 CD cord-015306-us58wwmp 2419 15 . . . cord-015306-us58wwmp 2420 1 5 5 LS cord-015306-us58wwmp 2420 2 [ [ -LRB- cord-015306-us58wwmp 2420 3 44.8 44.8 CD cord-015306-us58wwmp 2420 4 - - HYPH cord-015306-us58wwmp 2420 5 58.5 58.5 CD cord-015306-us58wwmp 2420 6 ] ] -RRB- cord-015306-us58wwmp 2420 7 vs. vs. FW cord-015306-us58wwmp 2420 8 34.0 34.0 CD cord-015306-us58wwmp 2420 9 [ [ -LRB- cord-015306-us58wwmp 2420 10 28.3 28.3 CD cord-015306-us58wwmp 2420 11 - - HYPH cord-015306-us58wwmp 2420 12 58.8 58.8 CD cord-015306-us58wwmp 2420 13 ] ] -RRB- cord-015306-us58wwmp 2420 14 ; ; : cord-015306-us58wwmp 2420 15 p<0.05 p<0.05 CD cord-015306-us58wwmp 2420 16 ) ) -RRB- cord-015306-us58wwmp 2420 17 . . . cord-015306-us58wwmp 2421 1 Higher high JJR cord-015306-us58wwmp 2421 2 levels level NNS cord-015306-us58wwmp 2421 3 of of IN cord-015306-us58wwmp 2421 4 sCr sCr NNS cord-015306-us58wwmp 2421 5 correspond correspond VBP cord-015306-us58wwmp 2421 6 with with IN cord-015306-us58wwmp 2421 7 higher high JJR cord-015306-us58wwmp 2421 8 urinary urinary JJ cord-015306-us58wwmp 2421 9 excretion excretion NN cord-015306-us58wwmp 2421 10 of of IN cord-015306-us58wwmp 2421 11 all all DT cord-015306-us58wwmp 2421 12 biomarkers biomarker NNS cord-015306-us58wwmp 2421 13 , , , cord-015306-us58wwmp 2421 14 especially especially RB cord-015306-us58wwmp 2421 15 in in IN cord-015306-us58wwmp 2421 16 neonates neonate NNS cord-015306-us58wwmp 2421 17 treated treat VBN cord-015306-us58wwmp 2421 18 with with IN cord-015306-us58wwmp 2421 19 GM GM NNP cord-015306-us58wwmp 2421 20 . . . cord-015306-us58wwmp 2422 1 The the DT cord-015306-us58wwmp 2422 2 average average JJ cord-015306-us58wwmp 2422 3 time time NN cord-015306-us58wwmp 2422 4 until until IN cord-015306-us58wwmp 2422 5 the the DT cord-015306-us58wwmp 2422 6 highest high JJS cord-015306-us58wwmp 2422 7 peak peak NN cord-015306-us58wwmp 2422 8 was be VBD cord-015306-us58wwmp 2422 9 shorter short JJR cord-015306-us58wwmp 2422 10 for for IN cord-015306-us58wwmp 2422 11 all all DT cord-015306-us58wwmp 2422 12 biomarkers biomarker NNS cord-015306-us58wwmp 2422 13 compared compare VBN cord-015306-us58wwmp 2422 14 with with IN cord-015306-us58wwmp 2422 15 sCr sCr NNS cord-015306-us58wwmp 2422 16 ( ( -LRB- cord-015306-us58wwmp 2422 17 p<0.05 p<0.05 CD cord-015306-us58wwmp 2422 18 ) ) -RRB- cord-015306-us58wwmp 2422 19 . . . cord-015306-us58wwmp 2423 1 There there EX cord-015306-us58wwmp 2423 2 was be VBD cord-015306-us58wwmp 2423 3 no no DT cord-015306-us58wwmp 2423 4 difference difference NN cord-015306-us58wwmp 2423 5 in in IN cord-015306-us58wwmp 2423 6 produced produce VBN cord-015306-us58wwmp 2423 7 urine urine NN cord-015306-us58wwmp 2423 8 volume volume NN cord-015306-us58wwmp 2423 9 between between IN cord-015306-us58wwmp 2423 10 the the DT cord-015306-us58wwmp 2423 11 GM GM NNP cord-015306-us58wwmp 2423 12 and and CC cord-015306-us58wwmp 2423 13 the the DT cord-015306-us58wwmp 2423 14 reference reference NN cord-015306-us58wwmp 2423 15 group group NN cord-015306-us58wwmp 2423 16 . . . cord-015306-us58wwmp 2424 1 Conclusion conclusion NN cord-015306-us58wwmp 2424 2 : : : cord-015306-us58wwmp 2425 1 Higher high JJR cord-015306-us58wwmp 2425 2 sCr sCr NNS cord-015306-us58wwmp 2425 3 levels level NNS cord-015306-us58wwmp 2425 4 correspond correspond VBP cord-015306-us58wwmp 2425 5 with with IN cord-015306-us58wwmp 2425 6 higher high JJR cord-015306-us58wwmp 2425 7 urinary urinary JJ cord-015306-us58wwmp 2425 8 excretion excretion NN cord-015306-us58wwmp 2425 9 of of IN cord-015306-us58wwmp 2425 10 all all DT cord-015306-us58wwmp 2425 11 biomarkers biomarker NNS cord-015306-us58wwmp 2425 12 , , , cord-015306-us58wwmp 2425 13 especially especially RB cord-015306-us58wwmp 2425 14 in in IN cord-015306-us58wwmp 2425 15 neonates neonate NNS cord-015306-us58wwmp 2425 16 treated treat VBN cord-015306-us58wwmp 2425 17 with with IN cord-015306-us58wwmp 2425 18 GM GM NNP cord-015306-us58wwmp 2425 19 . . . cord-015306-us58wwmp 2426 1 GSTP1 GSTP1 NNP cord-015306-us58wwmp 2426 2 - - HYPH cord-015306-us58wwmp 2426 3 1 1 NNP cord-015306-us58wwmp 2426 4 seems seem VBZ cord-015306-us58wwmp 2426 5 the the DT cord-015306-us58wwmp 2426 6 most most RBS cord-015306-us58wwmp 2426 7 useful useful JJ cord-015306-us58wwmp 2426 8 marker marker NN cord-015306-us58wwmp 2426 9 for for IN cord-015306-us58wwmp 2426 10 early early JJ cord-015306-us58wwmp 2426 11 detection detection NN cord-015306-us58wwmp 2426 12 of of IN cord-015306-us58wwmp 2426 13 AKI AKI NNP cord-015306-us58wwmp 2426 14 in in IN cord-015306-us58wwmp 2426 15 neonates neonate NNS cord-015306-us58wwmp 2426 16 . . . cord-015306-us58wwmp 2427 1 Seong Seong NNP cord-015306-us58wwmp 2427 2 Heon Heon NNP cord-015306-us58wwmp 2427 3 Kim Kim NNP cord-015306-us58wwmp 2427 4 , , , cord-015306-us58wwmp 2427 5 Sang Sang NNP cord-015306-us58wwmp 2427 6 Wook Wook NNP cord-015306-us58wwmp 2427 7 Mun Mun NNP cord-015306-us58wwmp 2427 8 , , , cord-015306-us58wwmp 2427 9 Su Su NNP cord-015306-us58wwmp 2427 10 Young Young NNP cord-015306-us58wwmp 2427 11 Kim Kim NNP cord-015306-us58wwmp 2427 12 1 1 CD cord-015306-us58wwmp 2427 13 1 1 CD cord-015306-us58wwmp 2427 14 . . . cord-015306-us58wwmp 2428 1 Pediatrics Pediatrics NNP cord-015306-us58wwmp 2428 2 , , , cord-015306-us58wwmp 2428 3 Pusan Pusan NNP cord-015306-us58wwmp 2428 4 National National NNP cord-015306-us58wwmp 2428 5 University University NNP cord-015306-us58wwmp 2428 6 Children Children NNP cord-015306-us58wwmp 2428 7 's 's POS cord-015306-us58wwmp 2428 8 Hospital Hospital NNP cord-015306-us58wwmp 2428 9 , , , cord-015306-us58wwmp 2428 10 Yangsan Yangsan NNP cord-015306-us58wwmp 2428 11 , , , cord-015306-us58wwmp 2428 12 Korea Korea NNP cord-015306-us58wwmp 2428 13 Objective Objective NNP cord-015306-us58wwmp 2428 14 : : : cord-015306-us58wwmp 2428 15 Spontaneous spontaneous JJ cord-015306-us58wwmp 2428 16 tumor tumor NN cord-015306-us58wwmp 2428 17 lysis lysis NN cord-015306-us58wwmp 2428 18 syndrome syndrome NN cord-015306-us58wwmp 2428 19 ( ( -LRB- cord-015306-us58wwmp 2428 20 STLS STLS NNP cord-015306-us58wwmp 2428 21 ) ) -RRB- cord-015306-us58wwmp 2428 22 before before IN cord-015306-us58wwmp 2428 23 cancer cancer NN cord-015306-us58wwmp 2428 24 treatment treatment NN cord-015306-us58wwmp 2428 25 is be VBZ cord-015306-us58wwmp 2428 26 rare rare JJ cord-015306-us58wwmp 2428 27 and and CC cord-015306-us58wwmp 2428 28 develop develop VBP cord-015306-us58wwmp 2428 29 mostly mostly RB cord-015306-us58wwmp 2428 30 in in IN cord-015306-us58wwmp 2428 31 Burkitt Burkitt NNP cord-015306-us58wwmp 2428 32 lymphoma lymphoma NN cord-015306-us58wwmp 2428 33 and and CC cord-015306-us58wwmp 2428 34 non non JJ cord-015306-us58wwmp 2428 35 - - JJ cord-015306-us58wwmp 2428 36 Hodgkin Hodgkin NNP cord-015306-us58wwmp 2428 37 lymphoma lymphoma NN cord-015306-us58wwmp 2428 38 . . . cord-015306-us58wwmp 2429 1 Here here RB cord-015306-us58wwmp 2429 2 we -PRON- PRP cord-015306-us58wwmp 2429 3 report report VBP cord-015306-us58wwmp 2429 4 a a DT cord-015306-us58wwmp 2429 5 case case NN cord-015306-us58wwmp 2429 6 of of IN cord-015306-us58wwmp 2429 7 STLS STLS NNP cord-015306-us58wwmp 2429 8 secondary secondary JJ cord-015306-us58wwmp 2429 9 to to IN cord-015306-us58wwmp 2429 10 Tcell Tcell NNP cord-015306-us58wwmp 2429 11 acute acute JJ cord-015306-us58wwmp 2429 12 lymphoblastic lymphoblastic JJ cord-015306-us58wwmp 2429 13 leukemia(ALL leukemia(ALL NNP cord-015306-us58wwmp 2429 14 ) ) -RRB- cord-015306-us58wwmp 2429 15 which which WDT cord-015306-us58wwmp 2429 16 presented present VBD cord-015306-us58wwmp 2429 17 with with IN cord-015306-us58wwmp 2429 18 renal renal JJ cord-015306-us58wwmp 2429 19 stone stone NN cord-015306-us58wwmp 2429 20 and and CC cord-015306-us58wwmp 2429 21 subsequent subsequent JJ cord-015306-us58wwmp 2429 22 AKI AKI NNP cord-015306-us58wwmp 2429 23 . . . cord-015306-us58wwmp 2430 1 Methods method NNS cord-015306-us58wwmp 2430 2 and and CC cord-015306-us58wwmp 2430 3 Results result NNS cord-015306-us58wwmp 2430 4 : : : cord-015306-us58wwmp 2431 1 A a DT cord-015306-us58wwmp 2431 2 6-year 6-year JJ cord-015306-us58wwmp 2431 3 - - HYPH cord-015306-us58wwmp 2431 4 old old JJ cord-015306-us58wwmp 2431 5 boy boy NN cord-015306-us58wwmp 2431 6 was be VBD cord-015306-us58wwmp 2431 7 admitted admit VBN cord-015306-us58wwmp 2431 8 to to IN cord-015306-us58wwmp 2431 9 our -PRON- PRP$ cord-015306-us58wwmp 2431 10 hospital hospital NN cord-015306-us58wwmp 2431 11 for for IN cord-015306-us58wwmp 2431 12 generalized generalized JJ cord-015306-us58wwmp 2431 13 tonic tonic JJ cord-015306-us58wwmp 2431 14 clonic clonic JJ cord-015306-us58wwmp 2431 15 seizure seizure NN cord-015306-us58wwmp 2431 16 . . . cord-015306-us58wwmp 2432 1 One one CD cord-015306-us58wwmp 2432 2 month month NN cord-015306-us58wwmp 2432 3 ago ago RB cord-015306-us58wwmp 2432 4 , , , cord-015306-us58wwmp 2432 5 He -PRON- PRP cord-015306-us58wwmp 2432 6 visited visit VBD cord-015306-us58wwmp 2432 7 other other JJ cord-015306-us58wwmp 2432 8 hospital hospital NN cord-015306-us58wwmp 2432 9 for for IN cord-015306-us58wwmp 2432 10 episodic episodic JJ cord-015306-us58wwmp 2432 11 right right JJ cord-015306-us58wwmp 2432 12 - - HYPH cord-015306-us58wwmp 2432 13 sided sided JJ cord-015306-us58wwmp 2432 14 flank flank NN cord-015306-us58wwmp 2432 15 pain pain NN cord-015306-us58wwmp 2432 16 and and CC cord-015306-us58wwmp 2432 17 evaluations evaluation NNS cord-015306-us58wwmp 2432 18 revealed reveal VBD cord-015306-us58wwmp 2432 19 microscopic microscopic JJ cord-015306-us58wwmp 2432 20 hematuria hematuria NN cord-015306-us58wwmp 2432 21 , , , cord-015306-us58wwmp 2432 22 hyperuricemia hyperuricemia NN cord-015306-us58wwmp 2432 23 and and CC cord-015306-us58wwmp 2432 24 stone stone NN cord-015306-us58wwmp 2432 25 on on IN cord-015306-us58wwmp 2432 26 right right JJ cord-015306-us58wwmp 2432 27 uretero uretero NN cord-015306-us58wwmp 2432 28 - - HYPH cord-015306-us58wwmp 2432 29 pelvic pelvic NN cord-015306-us58wwmp 2432 30 junction junction NN cord-015306-us58wwmp 2432 31 . . . cord-015306-us58wwmp 2433 1 His -PRON- PRP$ cord-015306-us58wwmp 2433 2 blood blood NN cord-015306-us58wwmp 2433 3 pressure pressure NN cord-015306-us58wwmp 2433 4 was be VBD cord-015306-us58wwmp 2433 5 160/90 160/90 CD cord-015306-us58wwmp 2433 6 mmHg mmHg NNS cord-015306-us58wwmp 2433 7 and and CC cord-015306-us58wwmp 2433 8 he -PRON- PRP cord-015306-us58wwmp 2433 9 did do VBD cord-015306-us58wwmp 2433 10 not not RB cord-015306-us58wwmp 2433 11 have have VB cord-015306-us58wwmp 2433 12 any any DT cord-015306-us58wwmp 2433 13 dysmorphic dysmorphic JJ cord-015306-us58wwmp 2433 14 features feature NNS cord-015306-us58wwmp 2434 1 and and CC cord-015306-us58wwmp 2434 2 he -PRON- PRP cord-015306-us58wwmp 2434 3 had have VBD cord-015306-us58wwmp 2434 4 developed develop VBN cord-015306-us58wwmp 2434 5 normally normally RB cord-015306-us58wwmp 2434 6 . . . cord-015306-us58wwmp 2435 1 Physical physical JJ cord-015306-us58wwmp 2435 2 examination examination NN cord-015306-us58wwmp 2435 3 showed show VBD cord-015306-us58wwmp 2435 4 tender tender JJ cord-015306-us58wwmp 2435 5 hepatomegaly hepatomegaly NNP cord-015306-us58wwmp 2435 6 ( ( -LRB- cord-015306-us58wwmp 2435 7 2 2 CD cord-015306-us58wwmp 2435 8 cm cm NNP cord-015306-us58wwmp 2435 9 below below IN cord-015306-us58wwmp 2435 10 costal costal NNP cord-015306-us58wwmp 2435 11 margin margin NNP cord-015306-us58wwmp 2435 12 ) ) -RRB- cord-015306-us58wwmp 2435 13 and and CC cord-015306-us58wwmp 2435 14 no no DT cord-015306-us58wwmp 2435 15 splenomegaly splenomegaly NN cord-015306-us58wwmp 2435 16 . . . cord-015306-us58wwmp 2436 1 His -PRON- PRP$ cord-015306-us58wwmp 2436 2 initial initial JJ cord-015306-us58wwmp 2436 3 laboratory laboratory NN cord-015306-us58wwmp 2436 4 findings finding NNS cord-015306-us58wwmp 2436 5 were be VBD cord-015306-us58wwmp 2436 6 as as IN cord-015306-us58wwmp 2436 7 follows follow VBZ cord-015306-us58wwmp 2436 8 : : : cord-015306-us58wwmp 2437 1 BUN BUN NNP cord-015306-us58wwmp 2437 2 119.3 119.3 CD cord-015306-us58wwmp 2438 1 mg mg NNP cord-015306-us58wwmp 2438 2 / / SYM cord-015306-us58wwmp 2438 3 dL dl NN cord-015306-us58wwmp 2438 4 , , , cord-015306-us58wwmp 2438 5 creatinine creatinine NN cord-015306-us58wwmp 2438 6 4.77 4.77 CD cord-015306-us58wwmp 2438 7 mg mg NNP cord-015306-us58wwmp 2438 8 / / SYM cord-015306-us58wwmp 2438 9 dL dl NN cord-015306-us58wwmp 2438 10 , , , cord-015306-us58wwmp 2438 11 uric uric NN cord-015306-us58wwmp 2438 12 acid acid NN cord-015306-us58wwmp 2439 1 47.6 47.6 CD cord-015306-us58wwmp 2439 2 mg mg NNP cord-015306-us58wwmp 2439 3 / / SYM cord-015306-us58wwmp 2439 4 dL dl NN cord-015306-us58wwmp 2440 1 , , , cord-015306-us58wwmp 2440 2 LDH LDH NNP cord-015306-us58wwmp 2440 3 460 460 CD cord-015306-us58wwmp 2440 4 IU IU NNP cord-015306-us58wwmp 2440 5 / / SYM cord-015306-us58wwmp 2440 6 L L NNP cord-015306-us58wwmp 2440 7 , , , cord-015306-us58wwmp 2440 8 WBC WBC NNP cord-015306-us58wwmp 2440 9 11,900 11,900 CD cord-015306-us58wwmp 2440 10 /uL /uL : cord-015306-us58wwmp 2440 11 , , , cord-015306-us58wwmp 2440 12 Hb Hb NNP cord-015306-us58wwmp 2440 13 9.9 9.9 CD cord-015306-us58wwmp 2440 14 g g NN cord-015306-us58wwmp 2440 15 / / SYM cord-015306-us58wwmp 2440 16 d d NNP cord-015306-us58wwmp 2440 17 L L NNP cord-015306-us58wwmp 2440 18 , , , cord-015306-us58wwmp 2440 19 platelet platelet NN cord-015306-us58wwmp 2440 20 242 242 CD cord-015306-us58wwmp 2440 21 K K NNP cord-015306-us58wwmp 2440 22 /u /u NNP cord-015306-us58wwmp 2440 23 L. L. NNP cord-015306-us58wwmp 2441 1 There there EX cord-015306-us58wwmp 2441 2 was be VBD cord-015306-us58wwmp 2441 3 no no DT cord-015306-us58wwmp 2441 4 blast blast NN cord-015306-us58wwmp 2441 5 on on IN cord-015306-us58wwmp 2441 6 his -PRON- PRP$ cord-015306-us58wwmp 2441 7 peripheral peripheral JJ cord-015306-us58wwmp 2441 8 blood blood NN cord-015306-us58wwmp 2441 9 smear smear NN cord-015306-us58wwmp 2441 10 test test NN cord-015306-us58wwmp 2441 11 . . . cord-015306-us58wwmp 2442 1 Emergent emergent JJ cord-015306-us58wwmp 2442 2 hemodialysis hemodialysis NN cord-015306-us58wwmp 2442 3 was be VBD cord-015306-us58wwmp 2442 4 started start VBN cord-015306-us58wwmp 2442 5 because because IN cord-015306-us58wwmp 2442 6 of of IN cord-015306-us58wwmp 2442 7 AKI AKI NNP cord-015306-us58wwmp 2442 8 , , , cord-015306-us58wwmp 2442 9 hypertension hypertension NN cord-015306-us58wwmp 2442 10 and and CC cord-015306-us58wwmp 2442 11 seizure seizure NN cord-015306-us58wwmp 2442 12 . . . cord-015306-us58wwmp 2443 1 His -PRON- PRP$ cord-015306-us58wwmp 2443 2 renal renal JJ cord-015306-us58wwmp 2443 3 function function NN cord-015306-us58wwmp 2443 4 , , , cord-015306-us58wwmp 2443 5 blood blood NN cord-015306-us58wwmp 2443 6 pressure pressure NN cord-015306-us58wwmp 2443 7 , , , cord-015306-us58wwmp 2443 8 uric uric NN cord-015306-us58wwmp 2443 9 acid acid NN cord-015306-us58wwmp 2443 10 and and CC cord-015306-us58wwmp 2443 11 electrolyte electrolyte JJ cord-015306-us58wwmp 2443 12 abnormalities abnormality NNS cord-015306-us58wwmp 2443 13 gradually gradually RB cord-015306-us58wwmp 2443 14 improved improve VBD cord-015306-us58wwmp 2443 15 with with IN cord-015306-us58wwmp 2443 16 appropriate appropriate JJ cord-015306-us58wwmp 2443 17 therapy therapy NN cord-015306-us58wwmp 2443 18 after after IN cord-015306-us58wwmp 2443 19 2 2 CD cord-015306-us58wwmp 2443 20 times time NNS cord-015306-us58wwmp 2443 21 of of IN cord-015306-us58wwmp 2443 22 hemodialysis hemodialysis NN cord-015306-us58wwmp 2443 23 . . . cord-015306-us58wwmp 2444 1 But but CC cord-015306-us58wwmp 2444 2 serum serum NN cord-015306-us58wwmp 2444 3 uric uric NN cord-015306-us58wwmp 2444 4 acid acid NN cord-015306-us58wwmp 2444 5 level level NN cord-015306-us58wwmp 2444 6 increased increase VBD cord-015306-us58wwmp 2444 7 again again RB cord-015306-us58wwmp 2444 8 ( ( -LRB- cord-015306-us58wwmp 2444 9 from from IN cord-015306-us58wwmp 2444 10 6.1 6.1 CD cord-015306-us58wwmp 2444 11 mg mg NNP cord-015306-us58wwmp 2444 12 / / SYM cord-015306-us58wwmp 2444 13 dL dl NN cord-015306-us58wwmp 2444 14 to to IN cord-015306-us58wwmp 2444 15 12.9 12.9 CD cord-015306-us58wwmp 2444 16 mg mg NNP cord-015306-us58wwmp 2444 17 / / SYM cord-015306-us58wwmp 2444 18 dL dL NNP cord-015306-us58wwmp 2444 19 ) ) -RRB- cord-015306-us58wwmp 2444 20 , , , cord-015306-us58wwmp 2444 21 so so RB cord-015306-us58wwmp 2444 22 allopurinol allopurinol NNP cord-015306-us58wwmp 2444 23 was be VBD cord-015306-us58wwmp 2444 24 added add VBN cord-015306-us58wwmp 2444 25 on on IN cord-015306-us58wwmp 2444 26 . . . cord-015306-us58wwmp 2445 1 The the DT cord-015306-us58wwmp 2445 2 cause cause NN cord-015306-us58wwmp 2445 3 of of IN cord-015306-us58wwmp 2445 4 AKI AKI NNP cord-015306-us58wwmp 2445 5 was be VBD cord-015306-us58wwmp 2445 6 unclear unclear JJ cord-015306-us58wwmp 2445 7 and and CC cord-015306-us58wwmp 2445 8 we -PRON- PRP cord-015306-us58wwmp 2445 9 thought think VBD cord-015306-us58wwmp 2445 10 that that IN cord-015306-us58wwmp 2445 11 AKI AKI NNP cord-015306-us58wwmp 2445 12 presumed presume VBD cord-015306-us58wwmp 2445 13 to to TO cord-015306-us58wwmp 2445 14 be be VB cord-015306-us58wwmp 2445 15 secondary secondary JJ cord-015306-us58wwmp 2445 16 to to TO cord-015306-us58wwmp 2445 17 acute acute JJ cord-015306-us58wwmp 2445 18 uric uric NN cord-015306-us58wwmp 2445 19 acid acid NN cord-015306-us58wwmp 2445 20 nephropathy nephropathy NN cord-015306-us58wwmp 2445 21 caused cause VBN cord-015306-us58wwmp 2445 22 by by IN cord-015306-us58wwmp 2445 23 STLS STLS NNP cord-015306-us58wwmp 2445 24 . . . cord-015306-us58wwmp 2446 1 After after IN cord-015306-us58wwmp 2446 2 few few JJ cord-015306-us58wwmp 2446 3 days day NNS cord-015306-us58wwmp 2446 4 , , , cord-015306-us58wwmp 2446 5 bone bone NN cord-015306-us58wwmp 2446 6 marrow marrow NN cord-015306-us58wwmp 2446 7 biopsy biopsy NN cord-015306-us58wwmp 2446 8 was be VBD cord-015306-us58wwmp 2446 9 done do VBN cord-015306-us58wwmp 2446 10 and and CC cord-015306-us58wwmp 2446 11 demonstrated demonstrate VBN cord-015306-us58wwmp 2446 12 normocellular normocellular JJ cord-015306-us58wwmp 2446 13 marrow marrow NN cord-015306-us58wwmp 2446 14 without without IN cord-015306-us58wwmp 2446 15 evidence evidence NN cord-015306-us58wwmp 2446 16 of of IN cord-015306-us58wwmp 2446 17 malignancy malignancy NN cord-015306-us58wwmp 2446 18 . . . cord-015306-us58wwmp 2447 1 After after IN cord-015306-us58wwmp 2447 2 day day NN cord-015306-us58wwmp 2447 3 15 15 CD cord-015306-us58wwmp 2447 4 of of IN cord-015306-us58wwmp 2447 5 hospitalization hospitalization NN cord-015306-us58wwmp 2447 6 , , , cord-015306-us58wwmp 2447 7 abdominal abdominal JJ cord-015306-us58wwmp 2447 8 pain pain NN cord-015306-us58wwmp 2447 9 with with IN cord-015306-us58wwmp 2447 10 hepatomegaly hepatomegaly NNP cord-015306-us58wwmp 2447 11 was be VBD cord-015306-us58wwmp 2447 12 getting get VBG cord-015306-us58wwmp 2447 13 worse bad JJR cord-015306-us58wwmp 2447 14 than than IN cord-015306-us58wwmp 2447 15 before before RB cord-015306-us58wwmp 2447 16 and and CC cord-015306-us58wwmp 2447 17 uncontrolled uncontrolled JJ cord-015306-us58wwmp 2447 18 high high JJ cord-015306-us58wwmp 2447 19 fever fever NN cord-015306-us58wwmp 2447 20 occurred occur VBD cord-015306-us58wwmp 2447 21 . . . cord-015306-us58wwmp 2448 1 20 20 CD cord-015306-us58wwmp 2448 2 % % NN cord-015306-us58wwmp 2448 3 of of IN cord-015306-us58wwmp 2448 4 blasts blast NNS cord-015306-us58wwmp 2448 5 were be VBD cord-015306-us58wwmp 2448 6 seen see VBN cord-015306-us58wwmp 2448 7 on on IN cord-015306-us58wwmp 2448 8 his -PRON- PRP$ cord-015306-us58wwmp 2448 9 peripheral peripheral JJ cord-015306-us58wwmp 2448 10 blood blood NN cord-015306-us58wwmp 2448 11 smear smear NN cord-015306-us58wwmp 2448 12 and and CC cord-015306-us58wwmp 2448 13 subsequent subsequent JJ cord-015306-us58wwmp 2448 14 second second JJ cord-015306-us58wwmp 2448 15 bone bone NN cord-015306-us58wwmp 2448 16 marrow marrow NN cord-015306-us58wwmp 2448 17 biopsy biopsy NN cord-015306-us58wwmp 2449 1 demonstrated demonstrate VBD cord-015306-us58wwmp 2449 2 acute acute JJ cord-015306-us58wwmp 2449 3 T T NNP cord-015306-us58wwmp 2449 4 cell cell NN cord-015306-us58wwmp 2449 5 lymphoblastic lymphoblastic NN cord-015306-us58wwmp 2449 6 leukemia leukemia NN cord-015306-us58wwmp 2449 7 . . . cord-015306-us58wwmp 2450 1 Then then RB cord-015306-us58wwmp 2450 2 , , , cord-015306-us58wwmp 2450 3 he -PRON- PRP cord-015306-us58wwmp 2450 4 was be VBD cord-015306-us58wwmp 2450 5 referred refer VBN cord-015306-us58wwmp 2450 6 to to IN cord-015306-us58wwmp 2450 7 division division NN cord-015306-us58wwmp 2450 8 of of IN cord-015306-us58wwmp 2450 9 pediatric pediatric JJ cord-015306-us58wwmp 2450 10 hemato hemato NNP cord-015306-us58wwmp 2450 11 - - HYPH cord-015306-us58wwmp 2450 12 oncology oncology NN cord-015306-us58wwmp 2450 13 on on IN cord-015306-us58wwmp 2450 14 our -PRON- PRP$ cord-015306-us58wwmp 2450 15 hospital hospital NN cord-015306-us58wwmp 2450 16 and and CC cord-015306-us58wwmp 2450 17 induction induction NN cord-015306-us58wwmp 2451 1 chemotherapy chemotherapy NN cord-015306-us58wwmp 2451 2 was be VBD cord-015306-us58wwmp 2451 3 started start VBN cord-015306-us58wwmp 2451 4 . . . cord-015306-us58wwmp 2452 1 Conclusion conclusion NN cord-015306-us58wwmp 2452 2 : : : cord-015306-us58wwmp 2453 1 STLS STLS NNP cord-015306-us58wwmp 2453 2 with with IN cord-015306-us58wwmp 2453 3 AKI AKI NNP cord-015306-us58wwmp 2453 4 is be VBZ cord-015306-us58wwmp 2453 5 very very RB cord-015306-us58wwmp 2453 6 uncommon uncommon JJ cord-015306-us58wwmp 2453 7 initial initial JJ cord-015306-us58wwmp 2453 8 presentation presentation NN cord-015306-us58wwmp 2453 9 of of IN cord-015306-us58wwmp 2453 10 leukemia leukemia NN cord-015306-us58wwmp 2453 11 and and CC cord-015306-us58wwmp 2453 12 STLS STLS NNP cord-015306-us58wwmp 2453 13 presenting present VBG cord-015306-us58wwmp 2453 14 with with IN cord-015306-us58wwmp 2453 15 renal renal JJ cord-015306-us58wwmp 2453 16 stone stone NN cord-015306-us58wwmp 2453 17 is be VBZ cord-015306-us58wwmp 2453 18 extremely extremely RB cord-015306-us58wwmp 2453 19 rare rare JJ cord-015306-us58wwmp 2453 20 . . . cord-015306-us58wwmp 2454 1 In in IN cord-015306-us58wwmp 2454 2 a a DT cord-015306-us58wwmp 2454 3 clinical clinical JJ cord-015306-us58wwmp 2454 4 situation situation NN cord-015306-us58wwmp 2454 5 of of IN cord-015306-us58wwmp 2454 6 marked marked JJ cord-015306-us58wwmp 2454 7 hyperuricemia hyperuricemia NN cord-015306-us58wwmp 2454 8 with with IN cord-015306-us58wwmp 2454 9 acute acute JJ cord-015306-us58wwmp 2454 10 kidney kidney NN cord-015306-us58wwmp 2454 11 injury injury NN cord-015306-us58wwmp 2454 12 , , , cord-015306-us58wwmp 2454 13 we -PRON- PRP cord-015306-us58wwmp 2454 14 need need VBP cord-015306-us58wwmp 2454 15 to to TO cord-015306-us58wwmp 2454 16 consider consider VB cord-015306-us58wwmp 2454 17 occult occult JJ cord-015306-us58wwmp 2454 18 malignancy malignancy NN cord-015306-us58wwmp 2454 19 and and CC cord-015306-us58wwmp 2454 20 STLS STLS NNP cord-015306-us58wwmp 2454 21 . . . cord-015306-us58wwmp 2455 1 The the DT cord-015306-us58wwmp 2455 2 application application NN cord-015306-us58wwmp 2455 3 of of IN cord-015306-us58wwmp 2455 4 Serum serum NN cord-015306-us58wwmp 2455 5 beta-2-microglobulin beta-2-microglobulin NNP cord-015306-us58wwmp 2455 6 ( ( -LRB- cord-015306-us58wwmp 2455 7 beta-2-MG beta-2-mg NN cord-015306-us58wwmp 2455 8 ) ) -RRB- cord-015306-us58wwmp 2455 9 and and CC cord-015306-us58wwmp 2455 10 cystatin cystatin JJ cord-015306-us58wwmp 2455 11 C(CysC)concentration c(cysc)concentration NN cord-015306-us58wwmp 2455 12 to to IN cord-015306-us58wwmp 2455 13 evaluation evaluation NN cord-015306-us58wwmp 2455 14 of of IN cord-015306-us58wwmp 2455 15 renal renal JJ cord-015306-us58wwmp 2455 16 function function NN cord-015306-us58wwmp 2455 17 impairment impairment NN cord-015306-us58wwmp 2455 18 in in IN cord-015306-us58wwmp 2455 19 patients patient NNS cord-015306-us58wwmp 2455 20 withneonatal withneonatal VBP cord-015306-us58wwmp 2455 21 jaundice jaundice NN cord-015306-us58wwmp 2455 22 Yanan Yanan NNP cord-015306-us58wwmp 2455 23 Xin Xin NNP cord-015306-us58wwmp 2455 24 , , , cord-015306-us58wwmp 2455 25 Cairong Cairong NNP cord-015306-us58wwmp 2455 26 Jiang Jiang NNP cord-015306-us58wwmp 2455 27 , , , cord-015306-us58wwmp 2455 28 Junfeng Junfeng NNP cord-015306-us58wwmp 2455 29 Yang Yang NNP cord-015306-us58wwmp 2455 30 , , , cord-015306-us58wwmp 2455 31 Hui Hui NNP cord-015306-us58wwmp 2455 32 Xu Xu NNP cord-015306-us58wwmp 2455 33 , , , cord-015306-us58wwmp 2455 34 Yuan Yuan NNP cord-015306-us58wwmp 2455 35 Zhang Zhang NNP cord-015306-us58wwmp 2456 1 The the DT cord-015306-us58wwmp 2456 2 Fourth Fourth NNP cord-015306-us58wwmp 2456 3 Hospital Hospital NNP cord-015306-us58wwmp 2456 4 of of IN cord-015306-us58wwmp 2456 5 Baotou Baotou NNP cord-015306-us58wwmp 2456 6 , , , cord-015306-us58wwmp 2456 7 Baotou Baotou NNP cord-015306-us58wwmp 2456 8 , , , cord-015306-us58wwmp 2457 1 China China NNP cord-015306-us58wwmp 2457 2 Objective Objective NNP cord-015306-us58wwmp 2457 3 : : : cord-015306-us58wwmp 2458 1 To to TO cord-015306-us58wwmp 2458 2 explore explore VB cord-015306-us58wwmp 2458 3 the the DT cord-015306-us58wwmp 2458 4 application application NN cord-015306-us58wwmp 2458 5 of of IN cord-015306-us58wwmp 2458 6 Serum Serum NNP cord-015306-us58wwmp 2458 7 beta-2-microglobulin beta-2-microglobulin NNP cord-015306-us58wwmp 2458 8 ( ( -LRB- cord-015306-us58wwmp 2458 9 beta-2-MG beta-2-mg NN cord-015306-us58wwmp 2458 10 ) ) -RRB- cord-015306-us58wwmp 2458 11 and and CC cord-015306-us58wwmp 2458 12 cystatin cystatin JJ cord-015306-us58wwmp 2458 13 C(CysC)concentration c(cysc)concentration NN cord-015306-us58wwmp 2458 14 to to IN cord-015306-us58wwmp 2458 15 evaluation evaluation NN cord-015306-us58wwmp 2458 16 of of IN cord-015306-us58wwmp 2458 17 renal renal JJ cord-015306-us58wwmp 2458 18 function function NN cord-015306-us58wwmp 2458 19 impairment impairment NN cord-015306-us58wwmp 2458 20 in in IN cord-015306-us58wwmp 2458 21 patients patient NNS cord-015306-us58wwmp 2458 22 with with IN cord-015306-us58wwmp 2458 23 neonatal neonatal JJ cord-015306-us58wwmp 2458 24 jaundice jaundice NN cord-015306-us58wwmp 2458 25 . . . cord-015306-us58wwmp 2459 1 Methods method NNS cord-015306-us58wwmp 2459 2 : : : cord-015306-us58wwmp 2459 3 60 60 CD cord-015306-us58wwmp 2459 4 neonates neonate NNS cord-015306-us58wwmp 2459 5 with with IN cord-015306-us58wwmp 2459 6 hyperbilirubinemia hyperbilirubinemia NN cord-015306-us58wwmp 2459 7 from from IN cord-015306-us58wwmp 2459 8 Jan. January NNP cord-015306-us58wwmp 2459 9 of of IN cord-015306-us58wwmp 2459 10 2012 2012 CD cord-015306-us58wwmp 2459 11 to to IN cord-015306-us58wwmp 2459 12 dec.of dec.of NNP cord-015306-us58wwmp 2459 13 2012 2012 CD cord-015306-us58wwmp 2459 14 in in IN cord-015306-us58wwmp 2459 15 pediatric pediatric JJ cord-015306-us58wwmp 2459 16 department department NN cord-015306-us58wwmp 2459 17 and and CC cord-015306-us58wwmp 2459 18 34 34 CD cord-015306-us58wwmp 2459 19 full full JJ cord-015306-us58wwmp 2459 20 term term NN cord-015306-us58wwmp 2459 21 infants infant NNS cord-015306-us58wwmp 2459 22 were be VBD cord-015306-us58wwmp 2459 23 chosen choose VBN cord-015306-us58wwmp 2459 24 as as IN cord-015306-us58wwmp 2459 25 research research NN cord-015306-us58wwmp 2459 26 object object NN cord-015306-us58wwmp 2459 27 , , , cord-015306-us58wwmp 2459 28 hyperbilirubinemia hyperbilirubinemia NN cord-015306-us58wwmp 2459 29 divided divide VBN cord-015306-us58wwmp 2459 30 into into IN cord-015306-us58wwmp 2459 31 mild mild JJ cord-015306-us58wwmp 2459 32 group group NN cord-015306-us58wwmp 2459 33 ( ( -LRB- cord-015306-us58wwmp 2459 34 bilirubin<256.5umol bilirubin<256.5umol NNP cord-015306-us58wwmp 2459 35 / / SYM cord-015306-us58wwmp 2459 36 L L NNP cord-015306-us58wwmp 2459 37 ) ) -RRB- cord-015306-us58wwmp 2459 38 and and CC cord-015306-us58wwmp 2459 39 moderate moderate JJ cord-015306-us58wwmp 2459 40 severe severe JJ cord-015306-us58wwmp 2460 1 ( ( -LRB- cord-015306-us58wwmp 2460 2 bilirubin bilirubin NN cord-015306-us58wwmp 2460 3 > > XX cord-015306-us58wwmp 2460 4 256.5umol 256.5umol CD cord-015306-us58wwmp 2460 5 / / SYM cord-015306-us58wwmp 2460 6 L L NNP cord-015306-us58wwmp 2460 7 ) ) -RRB- cord-015306-us58wwmp 2460 8 group group NN cord-015306-us58wwmp 2460 9 according accord VBG cord-015306-us58wwmp 2460 10 to to IN cord-015306-us58wwmp 2460 11 the the DT cord-015306-us58wwmp 2460 12 level level NN cord-015306-us58wwmp 2460 13 of of IN cord-015306-us58wwmp 2460 14 bilirubin bilirubin NN cord-015306-us58wwmp 2460 15 . . . cord-015306-us58wwmp 2461 1 The the DT cord-015306-us58wwmp 2461 2 different different JJ cord-015306-us58wwmp 2461 3 of of IN cord-015306-us58wwmp 2461 4 sex sex NN cord-015306-us58wwmp 2461 5 and and CC cord-015306-us58wwmp 2461 6 age age NN cord-015306-us58wwmp 2461 7 were be VBD cord-015306-us58wwmp 2461 8 not not RB cord-015306-us58wwmp 2461 9 significant significant JJ cord-015306-us58wwmp 2461 10 between between IN cord-015306-us58wwmp 2461 11 neonates neonate NNS cord-015306-us58wwmp 2461 12 with with IN cord-015306-us58wwmp 2461 13 hyperbilirubinemia hyperbilirubinemia NN cord-015306-us58wwmp 2461 14 and and CC cord-015306-us58wwmp 2461 15 control control NN cord-015306-us58wwmp 2461 16 group group NN cord-015306-us58wwmp 2461 17 . . . cord-015306-us58wwmp 2462 1 Serum serum NN cord-015306-us58wwmp 2462 2 beta-2-MG beta-2-mg NN cord-015306-us58wwmp 2462 3 , , , cord-015306-us58wwmp 2462 4 CysC CysC NNP cord-015306-us58wwmp 2462 5 , , , cord-015306-us58wwmp 2462 6 Cr Cr NNP cord-015306-us58wwmp 2462 7 and and CC cord-015306-us58wwmp 2462 8 BUN BUN NNP cord-015306-us58wwmp 2462 9 were be VBD cord-015306-us58wwmp 2462 10 measured measure VBN cord-015306-us58wwmp 2462 11 in in IN cord-015306-us58wwmp 2462 12 the the DT cord-015306-us58wwmp 2462 13 two two CD cord-015306-us58wwmp 2462 14 groups group NNS cord-015306-us58wwmp 2462 15 . . . cord-015306-us58wwmp 2463 1 Results result NNS cord-015306-us58wwmp 2463 2 : : : cord-015306-us58wwmp 2464 1 Serum serum NN cord-015306-us58wwmp 2464 2 beta-2-MG beta-2-mg NN cord-015306-us58wwmp 2464 3 and and CC cord-015306-us58wwmp 2464 4 CysC CysC NNP cord-015306-us58wwmp 2464 5 in in IN cord-015306-us58wwmp 2464 6 60 60 CD cord-015306-us58wwmp 2464 7 neonates neonate NNS cord-015306-us58wwmp 2464 8 of of IN cord-015306-us58wwmp 2464 9 hyperbilirubinemia hyperbilirubinemia NN cord-015306-us58wwmp 2464 10 were be VBD cord-015306-us58wwmp 2464 11 significantly significantly RB cord-015306-us58wwmp 2464 12 higher high JJR cord-015306-us58wwmp 2464 13 ( ( -LRB- cord-015306-us58wwmp 2464 14 P<0.01 P<0.01 NNS cord-015306-us58wwmp 2464 15 ) ) -RRB- cord-015306-us58wwmp 2464 16 than than IN cord-015306-us58wwmp 2464 17 healthy healthy JJ cord-015306-us58wwmp 2464 18 neonates neonate NNS cord-015306-us58wwmp 2464 19 , , , cord-015306-us58wwmp 2464 20 meanwhile meanwhile RB cord-015306-us58wwmp 2464 21 , , , cord-015306-us58wwmp 2464 22 Serum Serum NNP cord-015306-us58wwmp 2464 23 Cr Cr NNP cord-015306-us58wwmp 2464 24 and and CC cord-015306-us58wwmp 2464 25 BUN BUN NNP cord-015306-us58wwmp 2464 26 were be VBD cord-015306-us58wwmp 2464 27 significantly significantly RB cord-015306-us58wwmp 2464 28 lower low JJR cord-015306-us58wwmp 2464 29 ( ( -LRB- cord-015306-us58wwmp 2464 30 P<0.01 P<0.01 NNS cord-015306-us58wwmp 2464 31 ) ) -RRB- cord-015306-us58wwmp 2464 32 than than IN cord-015306-us58wwmp 2464 33 healthy healthy JJ cord-015306-us58wwmp 2464 34 neonates neonate NNS cord-015306-us58wwmp 2464 35 . . . cord-015306-us58wwmp 2465 1 After after IN cord-015306-us58wwmp 2465 2 treatment treatment NN cord-015306-us58wwmp 2465 3 , , , cord-015306-us58wwmp 2465 4 Serum serum NN cord-015306-us58wwmp 2465 5 beta-2-MG beta-2-MG NNP cord-015306-us58wwmp 2465 6 and and CC cord-015306-us58wwmp 2465 7 CysC CysC NNP cord-015306-us58wwmp 2465 8 of of IN cord-015306-us58wwmp 2465 9 neonates neonate NNS cord-015306-us58wwmp 2465 10 with with IN cord-015306-us58wwmp 2465 11 hyperbilirubinemia hyperbilirubinemia NNP cord-015306-us58wwmp 2465 12 were be VBD cord-015306-us58wwmp 2465 13 significantly significantly RB cord-015306-us58wwmp 2465 14 lower low JJR cord-015306-us58wwmp 2465 15 ( ( -LRB- cord-015306-us58wwmp 2465 16 P<0.01 P<0.01 NNS cord-015306-us58wwmp 2465 17 ) ) -RRB- cord-015306-us58wwmp 2465 18 than than IN cord-015306-us58wwmp 2465 19 pretreatment pretreatment NN cord-015306-us58wwmp 2465 20 . . . cord-015306-us58wwmp 2466 1 However however RB cord-015306-us58wwmp 2466 2 , , , cord-015306-us58wwmp 2466 3 Serum serum NN cord-015306-us58wwmp 2466 4 beta-2-MG beta-2-mg CD cord-015306-us58wwmp 2466 5 were be VBD cord-015306-us58wwmp 2466 6 higher high JJR cord-015306-us58wwmp 2467 1 ( ( -LRB- cord-015306-us58wwmp 2467 2 P>0.05 P>0.05 NNP cord-015306-us58wwmp 2467 3 ) ) -RRB- cord-015306-us58wwmp 2467 4 abeta abeta NNP cord-015306-us58wwmp 2467 5 - - HYPH cord-015306-us58wwmp 2467 6 d d NNP cord-015306-us58wwmp 2467 7 CysC CysC NNP cord-015306-us58wwmp 2467 8 were be VBD cord-015306-us58wwmp 2467 9 significantly significantly RB cord-015306-us58wwmp 2467 10 higher high JJR cord-015306-us58wwmp 2467 11 ( ( -LRB- cord-015306-us58wwmp 2467 12 P<0.01 P<0.01 NNS cord-015306-us58wwmp 2467 13 ) ) -RRB- cord-015306-us58wwmp 2467 14 than than IN cord-015306-us58wwmp 2467 15 normal normal JJ cord-015306-us58wwmp 2467 16 group group NN cord-015306-us58wwmp 2467 17 . . . cord-015306-us58wwmp 2468 1 But but CC cord-015306-us58wwmp 2468 2 there there EX cord-015306-us58wwmp 2468 3 was be VBD cord-015306-us58wwmp 2468 4 no no DT cord-015306-us58wwmp 2468 5 significant significant JJ cord-015306-us58wwmp 2468 6 difference difference NN cord-015306-us58wwmp 2468 7 between between IN cord-015306-us58wwmp 2468 8 mild mild JJ cord-015306-us58wwmp 2468 9 and and CC cord-015306-us58wwmp 2468 10 moderate moderate JJ cord-015306-us58wwmp 2468 11 severe severe JJ cord-015306-us58wwmp 2468 12 group group NN cord-015306-us58wwmp 2468 13 in in IN cord-015306-us58wwmp 2468 14 the the DT cord-015306-us58wwmp 2468 15 level level NN cord-015306-us58wwmp 2468 16 of of IN cord-015306-us58wwmp 2468 17 Serum serum NN cord-015306-us58wwmp 2468 18 beta-2-MG beta-2-MG NNP cord-015306-us58wwmp 2468 19 , , , cord-015306-us58wwmp 2468 20 CysC CysC NNP cord-015306-us58wwmp 2468 21 , , , cord-015306-us58wwmp 2468 22 Cr Cr NNP cord-015306-us58wwmp 2468 23 and and CC cord-015306-us58wwmp 2468 24 BUN(P>0.05 BUN(P>0.05 NNP cord-015306-us58wwmp 2468 25 ) ) -RRB- cord-015306-us58wwmp 2468 26 . . . cord-015306-us58wwmp 2469 1 The the DT cord-015306-us58wwmp 2469 2 result result NN cord-015306-us58wwmp 2469 3 implied imply VBD cord-015306-us58wwmp 2469 4 that that IN cord-015306-us58wwmp 2469 5 neonates neonate NNS cord-015306-us58wwmp 2469 6 with with IN cord-015306-us58wwmp 2469 7 hyperbilirubinemia hyperbilirubinemia NN cord-015306-us58wwmp 2469 8 suffered suffer VBN cord-015306-us58wwmp 2469 9 for for IN cord-015306-us58wwmp 2469 10 renal renal JJ cord-015306-us58wwmp 2469 11 function function NN cord-015306-us58wwmp 2469 12 to to IN cord-015306-us58wwmp 2469 13 varying vary VBG cord-015306-us58wwmp 2469 14 degrees degree NNS cord-015306-us58wwmp 2469 15 . . . cord-015306-us58wwmp 2470 1 Howerer Howerer NNP cord-015306-us58wwmp 2470 2 , , , cord-015306-us58wwmp 2470 3 the the DT cord-015306-us58wwmp 2470 4 damage damage NN cord-015306-us58wwmp 2470 5 can can MD cord-015306-us58wwmp 2470 6 partially partially RB cord-015306-us58wwmp 2470 7 recovered recover VBN cord-015306-us58wwmp 2470 8 after after IN cord-015306-us58wwmp 2470 9 energetic energetic JJ cord-015306-us58wwmp 2470 10 treatment treatment NN cord-015306-us58wwmp 2470 11 . . . cord-015306-us58wwmp 2471 1 Clinical clinical JJ cord-015306-us58wwmp 2471 2 and and CC cord-015306-us58wwmp 2471 3 pathological pathological JJ cord-015306-us58wwmp 2471 4 analysis analysis NN cord-015306-us58wwmp 2471 5 of of IN cord-015306-us58wwmp 2471 6 IgA IgA NNP cord-015306-us58wwmp 2471 7 nephropathy nephropathy NNP cord-015306-us58wwmp 2471 8 with with IN cord-015306-us58wwmp 2471 9 acute acute JJ cord-015306-us58wwmp 2471 10 kidney kidney NN cord-015306-us58wwmp 2471 11 injury injury NN cord-015306-us58wwmp 2471 12 Minguang Minguang NNP cord-015306-us58wwmp 2471 13 Chen Chen NNP cord-015306-us58wwmp 2471 14 , , , cord-015306-us58wwmp 2471 15 Xiaohua Xiaohua NNP cord-015306-us58wwmp 2471 16 Ye Ye NNP cord-015306-us58wwmp 2471 17 , , , cord-015306-us58wwmp 2471 18 Qing Qing NNP cord-015306-us58wwmp 2471 19 Yang Yang NNP cord-015306-us58wwmp 2471 20 Nephrology Nephrology NNP cord-015306-us58wwmp 2471 21 , , , cord-015306-us58wwmp 2471 22 Yuying Yuying NNP cord-015306-us58wwmp 2471 23 children child NNS cord-015306-us58wwmp 2471 24 's 's POS cord-015306-us58wwmp 2471 25 Hospital Hospital NNP cord-015306-us58wwmp 2471 26 , , , cord-015306-us58wwmp 2471 27 Wenzhou Wenzhou NNP cord-015306-us58wwmp 2471 28 , , , cord-015306-us58wwmp 2472 1 China China NNP cord-015306-us58wwmp 2472 2 Objective Objective NNP cord-015306-us58wwmp 2472 3 : : : cord-015306-us58wwmp 2472 4 To to TO cord-015306-us58wwmp 2472 5 investigate investigate VB cord-015306-us58wwmp 2472 6 the the DT cord-015306-us58wwmp 2472 7 incidence incidence NN cord-015306-us58wwmp 2472 8 , , , cord-015306-us58wwmp 2472 9 etiology etiology NN cord-015306-us58wwmp 2472 10 , , , cord-015306-us58wwmp 2472 11 clinical clinical JJ cord-015306-us58wwmp 2472 12 pathological pathological JJ cord-015306-us58wwmp 2472 13 characteristics characteristic NNS cord-015306-us58wwmp 2472 14 and and CC cord-015306-us58wwmp 2472 15 prognosis prognosis NN cord-015306-us58wwmp 2472 16 in in IN cord-015306-us58wwmp 2472 17 primary primary JJ cord-015306-us58wwmp 2472 18 IgA IgA NNP cord-015306-us58wwmp 2472 19 nephropathy(IgAN nephropathy(IgAN NNP cord-015306-us58wwmp 2472 20 ) ) -RRB- cord-015306-us58wwmp 2472 21 children child NNS cord-015306-us58wwmp 2472 22 with with IN cord-015306-us58wwmp 2472 23 acute acute JJ cord-015306-us58wwmp 2472 24 kidney kidney NN cord-015306-us58wwmp 2472 25 injury(AKI injury(AKI NNP cord-015306-us58wwmp 2472 26 ) ) -RRB- cord-015306-us58wwmp 2472 27 . . . cord-015306-us58wwmp 2473 1 Methods method NNS cord-015306-us58wwmp 2473 2 : : : cord-015306-us58wwmp 2473 3 Retrospectively retrospectively RB cord-015306-us58wwmp 2473 4 analysis analysis VB cord-015306-us58wwmp 2473 5 the the DT cord-015306-us58wwmp 2473 6 clinical clinical JJ cord-015306-us58wwmp 2473 7 and and CC cord-015306-us58wwmp 2473 8 pathological pathological JJ cord-015306-us58wwmp 2473 9 manifestations manifestation NNS cord-015306-us58wwmp 2473 10 and and CC cord-015306-us58wwmp 2473 11 follow follow VB cord-015306-us58wwmp 2473 12 - - HYPH cord-015306-us58wwmp 2473 13 up up RP cord-015306-us58wwmp 2473 14 results result NNS cord-015306-us58wwmp 2473 15 of of IN cord-015306-us58wwmp 2473 16 Chlidren Chlidren NNP cord-015306-us58wwmp 2473 17 with with IN cord-015306-us58wwmp 2473 18 primary primary JJ cord-015306-us58wwmp 2473 19 IgAN IgAN NNP cord-015306-us58wwmp 2473 20 and and CC cord-015306-us58wwmp 2473 21 AKI AKI NNP cord-015306-us58wwmp 2473 22 in in IN cord-015306-us58wwmp 2473 23 our -PRON- PRP$ cord-015306-us58wwmp 2473 24 department department NN cord-015306-us58wwmp 2473 25 from from IN cord-015306-us58wwmp 2473 26 January,1996 January,1996 NNP cord-015306-us58wwmp 2473 27 to to IN cord-015306-us58wwmp 2473 28 Jun Jun NNP cord-015306-us58wwmp 2473 29 , , , cord-015306-us58wwmp 2473 30 2012 2012 CD cord-015306-us58wwmp 2473 31 . . . cord-015306-us58wwmp 2474 1 Results result NNS cord-015306-us58wwmp 2474 2 : : : cord-015306-us58wwmp 2475 1 There there EX cord-015306-us58wwmp 2475 2 were be VBD cord-015306-us58wwmp 2475 3 19 19 CD cord-015306-us58wwmp 2475 4 cases case NNS cord-015306-us58wwmp 2475 5 with with IN cord-015306-us58wwmp 2475 6 AKI AKI NNP cord-015306-us58wwmp 2475 7 in in IN cord-015306-us58wwmp 2475 8 196 196 CD cord-015306-us58wwmp 2475 9 Chlidren Chlidren NNP cord-015306-us58wwmp 2475 10 with with IN cord-015306-us58wwmp 2475 11 IgAN(9.7 IgAN(9.7 NNP cord-015306-us58wwmp 2475 12 % % NN cord-015306-us58wwmp 2475 13 ) ) -RRB- cord-015306-us58wwmp 2475 14 , , , cord-015306-us58wwmp 2475 15 The the DT cord-015306-us58wwmp 2475 16 peak peak NN cord-015306-us58wwmp 2475 17 serum serum NN cord-015306-us58wwmp 2475 18 creatinine creatinine NN cord-015306-us58wwmp 2475 19 were be VBD cord-015306-us58wwmp 2475 20 from from IN cord-015306-us58wwmp 2475 21 94.5umol/ 94.5umol/ CD cord-015306-us58wwmp 2475 22 to to IN cord-015306-us58wwmp 2475 23 282 282 CD cord-015306-us58wwmp 2475 24 umol umol JJ cord-015306-us58wwmp 2475 25 / / SYM cord-015306-us58wwmp 2475 26 L. L. NNP cord-015306-us58wwmp 2475 27 Histological Histological NNP cord-015306-us58wwmp 2475 28 changes change VBZ cord-015306-us58wwmp 2475 29 : : : cord-015306-us58wwmp 2475 30 with with IN cord-015306-us58wwmp 2475 31 the the DT cord-015306-us58wwmp 2475 32 formation formation NN cord-015306-us58wwmp 2475 33 of of IN cord-015306-us58wwmp 2475 34 crescent crescent NN cord-015306-us58wwmp 2475 35 in in IN cord-015306-us58wwmp 2475 36 10 10 CD cord-015306-us58wwmp 2475 37 cases case NNS cord-015306-us58wwmp 2475 38 , , , cord-015306-us58wwmp 2475 39 diffuse diffuse VB cord-015306-us58wwmp 2475 40 endocapillary endocapillary JJ cord-015306-us58wwmp 2475 41 proliferation proliferation NN cord-015306-us58wwmp 2475 42 in in IN cord-015306-us58wwmp 2475 43 5 5 CD cord-015306-us58wwmp 2475 44 example example NN cord-015306-us58wwmp 2475 45 , , , cord-015306-us58wwmp 2475 46 15 15 CD cord-015306-us58wwmp 2475 47 cases case NNS cord-015306-us58wwmp 2475 48 of of IN cord-015306-us58wwmp 2475 49 renal renal JJ cord-015306-us58wwmp 2475 50 tubular tubular JJ cord-015306-us58wwmp 2475 51 injury injury NN cord-015306-us58wwmp 2475 52 , , , cord-015306-us58wwmp 2475 53 10 10 CD cord-015306-us58wwmp 2475 54 cases case NNS cord-015306-us58wwmp 2475 55 of of IN cord-015306-us58wwmp 2475 56 red red JJ cord-015306-us58wwmp 2475 57 blood blood NN cord-015306-us58wwmp 2475 58 cell cell NN cord-015306-us58wwmp 2475 59 and and CC cord-015306-us58wwmp 2475 60 protein protein NN cord-015306-us58wwmp 2475 61 cast cast NN cord-015306-us58wwmp 2475 62 , , , cord-015306-us58wwmp 2475 63 1 1 CD cord-015306-us58wwmp 2475 64 cases case NNS cord-015306-us58wwmp 2475 65 with with IN cord-015306-us58wwmp 2475 66 acute acute JJ cord-015306-us58wwmp 2475 67 interstitial interstitial JJ cord-015306-us58wwmp 2475 68 nephritis nephritis NN cord-015306-us58wwmp 2475 69 . . . cord-015306-us58wwmp 2476 1 Multivariate multivariate JJ cord-015306-us58wwmp 2476 2 logistic logistic JJ cord-015306-us58wwmp 2476 3 regression regression NN cord-015306-us58wwmp 2476 4 analysis analysis NN cord-015306-us58wwmp 2476 5 showed show VBD cord-015306-us58wwmp 2476 6 : : : cord-015306-us58wwmp 2476 7 with with IN cord-015306-us58wwmp 2476 8 massive massive JJ cord-015306-us58wwmp 2476 9 proteinuria proteinuria NN cord-015306-us58wwmp 2476 10 were be VBD cord-015306-us58wwmp 2476 11 independent independent JJ cord-015306-us58wwmp 2476 12 risk risk NN cord-015306-us58wwmp 2476 13 factors factor NNS cord-015306-us58wwmp 2476 14 of of IN cord-015306-us58wwmp 2476 15 IgAN IgAN NNP cord-015306-us58wwmp 2476 16 in in IN cord-015306-us58wwmp 2476 17 children child NNS cord-015306-us58wwmp 2476 18 with with IN cord-015306-us58wwmp 2476 19 AKI AKI NNP cord-015306-us58wwmp 2476 20 ( ( -LRB- cord-015306-us58wwmp 2476 21 OR or CC cord-015306-us58wwmp 2477 1 = = SYM cord-015306-us58wwmp 2477 2 27.370 27.370 CD cord-015306-us58wwmp 2477 3 , , , cord-015306-us58wwmp 2477 4 95 95 CD cord-015306-us58wwmp 2477 5 % % NN cord-015306-us58wwmp 2477 6 confidence confidence NN cord-015306-us58wwmp 2477 7 interval interval NN cord-015306-us58wwmp 2477 8 was be VBD cord-015306-us58wwmp 2477 9 3.151 3.151 CD cord-015306-us58wwmp 2477 10 - - SYM cord-015306-us58wwmp 2477 11 237.740 237.740 CD cord-015306-us58wwmp 2477 12 , , , cord-015306-us58wwmp 2477 13 P<0.01 p<0.01 CD cord-015306-us58wwmp 2477 14 ) ) -RRB- cord-015306-us58wwmp 2477 15 . . . cord-015306-us58wwmp 2478 1 The the DT cord-015306-us58wwmp 2478 2 etiology etiology NN cord-015306-us58wwmp 2478 3 of of IN cord-015306-us58wwmp 2478 4 AKI AKI NNP cord-015306-us58wwmp 2478 5 except except IN cord-015306-us58wwmp 2478 6 with with IN cord-015306-us58wwmp 2478 7 massive massive JJ cord-015306-us58wwmp 2478 8 proteinuria proteinuria NN cord-015306-us58wwmp 2478 9 , , , cord-015306-us58wwmp 2478 10 include include VBP cord-015306-us58wwmp 2478 11 : : : cord-015306-us58wwmp 2478 12 1 1 CD cord-015306-us58wwmp 2478 13 . . . cord-015306-us58wwmp 2479 1 IgA IgA NNP cord-015306-us58wwmp 2479 2 nephropathy nephropathy NNP cord-015306-us58wwmp 2479 3 with with IN cord-015306-us58wwmp 2479 4 severe severe JJ cord-015306-us58wwmp 2479 5 glomerular glomerular JJ cord-015306-us58wwmp 2479 6 damage damage NN cord-015306-us58wwmp 2479 7 , , , cord-015306-us58wwmp 2479 8 including include VBG cord-015306-us58wwmp 2479 9 crescentic crescentic JJ cord-015306-us58wwmp 2479 10 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 2479 11 and and CC cord-015306-us58wwmp 2479 12 diffuse diffuse VB cord-015306-us58wwmp 2479 13 endocapillary endocapillary JJ cord-015306-us58wwmp 2479 14 proliferation proliferation NN cord-015306-us58wwmp 2479 15 ; ; : cord-015306-us58wwmp 2479 16 2 2 CD cord-015306-us58wwmp 2479 17 complicated complicated JJ cord-015306-us58wwmp 2479 18 acute acute JJ cord-015306-us58wwmp 2479 19 interstitial interstitial JJ cord-015306-us58wwmp 2479 20 nephritis nephritis NN cord-015306-us58wwmp 2479 21 ; ; : cord-015306-us58wwmp 2479 22 3 3 CD cord-015306-us58wwmp 2479 23 drugs drug NNS cord-015306-us58wwmp 2479 24 causing cause VBG cord-015306-us58wwmp 2479 25 decreased decrease VBD cord-015306-us58wwmp 2479 26 glomerular glomerular JJ cord-015306-us58wwmp 2479 27 filtration filtration NN cord-015306-us58wwmp 2479 28 rate rate NN cord-015306-us58wwmp 2479 29 ; ; : cord-015306-us58wwmp 2479 30 4 4 CD cord-015306-us58wwmp 2479 31 . . . cord-015306-us58wwmp 2480 1 renal renal JJ cord-015306-us58wwmp 2480 2 tubular tubular JJ cord-015306-us58wwmp 2480 3 injury injury NN cord-015306-us58wwmp 2480 4 induced induce VBN cord-015306-us58wwmp 2480 5 by by IN cord-015306-us58wwmp 2480 6 gross gross JJ cord-015306-us58wwmp 2480 7 hematuria hematuria NN cord-015306-us58wwmp 2480 8 . . . cord-015306-us58wwmp 2481 1 All all DT cord-015306-us58wwmp 2481 2 of of IN cord-015306-us58wwmp 2481 3 the the DT cord-015306-us58wwmp 2481 4 patients patient NNS cord-015306-us58wwmp 2481 5 were be VBD cord-015306-us58wwmp 2481 6 not not RB cord-015306-us58wwmp 2481 7 on on IN cord-015306-us58wwmp 2481 8 dialysis dialysis NN cord-015306-us58wwmp 2481 9 , , , cord-015306-us58wwmp 2481 10 hormone hormone NN cord-015306-us58wwmp 2481 11 therapy therapy NN cord-015306-us58wwmp 2481 12 in in IN cord-015306-us58wwmp 2481 13 13 13 CD cord-015306-us58wwmp 2481 14 cases case NNS cord-015306-us58wwmp 2481 15 ( ( -LRB- cord-015306-us58wwmp 2481 16 including include VBG cord-015306-us58wwmp 2481 17 7 7 CD cord-015306-us58wwmp 2481 18 cases case NNS cord-015306-us58wwmp 2481 19 of of IN cord-015306-us58wwmp 2481 20 methylprednisolone methylprednisolone JJ cord-015306-us58wwmp 2481 21 pulse pulse NN cord-015306-us58wwmp 2481 22 therapy therapy NN cord-015306-us58wwmp 2481 23 ) ) -RRB- cord-015306-us58wwmp 2481 24 , , , cord-015306-us58wwmp 2481 25 6 6 CD cord-015306-us58wwmp 2481 26 cases case NNS cord-015306-us58wwmp 2481 27 combined combine VBN cord-015306-us58wwmp 2481 28 with with IN cord-015306-us58wwmp 2481 29 cyclophosphamide cyclophosphamide JJ cord-015306-us58wwmp 2481 30 treatment treatment NN cord-015306-us58wwmp 2481 31 . . . cord-015306-us58wwmp 2482 1 Except except IN cord-015306-us58wwmp 2482 2 1 1 CD cord-015306-us58wwmp 2482 3 cases case NNS cord-015306-us58wwmp 2482 4 no no DT cord-015306-us58wwmp 2482 5 significant significant JJ cord-015306-us58wwmp 2482 6 improvement improvement NN cord-015306-us58wwmp 2482 7 , , , cord-015306-us58wwmp 2482 8 the the DT cord-015306-us58wwmp 2482 9 renal renal JJ cord-015306-us58wwmp 2482 10 functiones functione NNS cord-015306-us58wwmp 2482 11 of of IN cord-015306-us58wwmp 2482 12 all all DT cord-015306-us58wwmp 2482 13 patients patient NNS cord-015306-us58wwmp 2482 14 recovered recover VBD cord-015306-us58wwmp 2482 15 or or CC cord-015306-us58wwmp 2482 16 improved improve VBN cord-015306-us58wwmp 2482 17 within within IN cord-015306-us58wwmp 2482 18 1 1 CD cord-015306-us58wwmp 2482 19 - - SYM cord-015306-us58wwmp 2482 20 2 2 CD cord-015306-us58wwmp 2482 21 months month NNS cord-015306-us58wwmp 2482 22 after after IN cord-015306-us58wwmp 2482 23 treatment treatment NN cord-015306-us58wwmp 2482 24 . . . cord-015306-us58wwmp 2483 1 Follow follow VB cord-015306-us58wwmp 2483 2 - - HYPH cord-015306-us58wwmp 2483 3 up up NN cord-015306-us58wwmp 2483 4 from from IN cord-015306-us58wwmp 2483 5 1 1 CD cord-015306-us58wwmp 2483 6 month month NN cord-015306-us58wwmp 2483 7 to to IN cord-015306-us58wwmp 2483 8 7 7 CD cord-015306-us58wwmp 2483 9 years year NNS cord-015306-us58wwmp 2483 10 , , , cord-015306-us58wwmp 2483 11 3 3 CD cord-015306-us58wwmp 2483 12 cases case NNS cord-015306-us58wwmp 2483 13 had have VBD cord-015306-us58wwmp 2483 14 renal renal JJ cord-015306-us58wwmp 2483 15 function function NN cord-015306-us58wwmp 2483 16 improved improve VBN cord-015306-us58wwmp 2483 17 , , , cord-015306-us58wwmp 2483 18 but but CC cord-015306-us58wwmp 2483 19 2 2 CD cord-015306-us58wwmp 2483 20 were be VBD cord-015306-us58wwmp 2483 21 lost lose VBN cord-015306-us58wwmp 2483 22 to to TO cord-015306-us58wwmp 2483 23 follow follow VB cord-015306-us58wwmp 2483 24 - - HYPH cord-015306-us58wwmp 2483 25 up up NN cord-015306-us58wwmp 2483 26 and and CC cord-015306-us58wwmp 2483 27 after after IN cord-015306-us58wwmp 2483 28 3 3 CD cord-015306-us58wwmp 2483 29 years year NNS cord-015306-us58wwmp 2483 30 enter enter VBP cord-015306-us58wwmp 2483 31 to to IN cord-015306-us58wwmp 2483 32 the the DT cord-015306-us58wwmp 2483 33 chronic chronic JJ cord-015306-us58wwmp 2483 34 renal renal JJ cord-015306-us58wwmp 2483 35 failure failure NN cord-015306-us58wwmp 2483 36 , , , cord-015306-us58wwmp 2483 37 1 1 CD cord-015306-us58wwmp 2483 38 case case NN cord-015306-us58wwmp 2483 39 with with IN cord-015306-us58wwmp 2483 40 renal renal JJ cord-015306-us58wwmp 2483 41 function function NN cord-015306-us58wwmp 2483 42 loss loss NN cord-015306-us58wwmp 2483 43 after after IN cord-015306-us58wwmp 2483 44 32 32 CD cord-015306-us58wwmp 2483 45 months month NNS cord-015306-us58wwmp 2483 46 and and CC cord-015306-us58wwmp 2483 47 repeated repeated JJ cord-015306-us58wwmp 2483 48 renal renal JJ cord-015306-us58wwmp 2483 49 biopsy biopsy NN cord-015306-us58wwmp 2483 50 showed show VBD cord-015306-us58wwmp 2483 51 glomerular glomerular JJ cord-015306-us58wwmp 2483 52 sclerosis sclerosis NN cord-015306-us58wwmp 2483 53 of of IN cord-015306-us58wwmp 2483 54 31.6 31.6 CD cord-015306-us58wwmp 2483 55 % % NN cord-015306-us58wwmp 2483 56 during during IN cord-015306-us58wwmp 2483 57 the the DT cord-015306-us58wwmp 2483 58 follow follow NN cord-015306-us58wwmp 2483 59 - - HYPH cord-015306-us58wwmp 2483 60 up up NN cord-015306-us58wwmp 2483 61 period period NN cord-015306-us58wwmp 2483 62 . . . cord-015306-us58wwmp 2484 1 Conclusion conclusion NN cord-015306-us58wwmp 2484 2 : : : cord-015306-us58wwmp 2485 1 AKI AKI NNP cord-015306-us58wwmp 2485 2 is be VBZ cord-015306-us58wwmp 2485 3 not not RB cord-015306-us58wwmp 2485 4 uncommon uncommon JJ cord-015306-us58wwmp 2485 5 in in IN cord-015306-us58wwmp 2485 6 children child NNS cord-015306-us58wwmp 2485 7 with with IN cord-015306-us58wwmp 2485 8 IgAN IgAN NNP cord-015306-us58wwmp 2485 9 , , , cord-015306-us58wwmp 2485 10 the the DT cord-015306-us58wwmp 2485 11 causes cause NNS cord-015306-us58wwmp 2485 12 are be VBP cord-015306-us58wwmp 2485 13 varied varied JJ cord-015306-us58wwmp 2485 14 and and CC cord-015306-us58wwmp 2485 15 massive massive JJ cord-015306-us58wwmp 2485 16 proteinuria proteinuria NN cord-015306-us58wwmp 2485 17 is be VBZ cord-015306-us58wwmp 2485 18 independent independent JJ cord-015306-us58wwmp 2485 19 risk risk NN cord-015306-us58wwmp 2485 20 factor factor NN cord-015306-us58wwmp 2485 21 among among IN cord-015306-us58wwmp 2485 22 them -PRON- PRP cord-015306-us58wwmp 2485 23 . . . cord-015306-us58wwmp 2486 1 We -PRON- PRP cord-015306-us58wwmp 2486 2 should should MD cord-015306-us58wwmp 2486 3 adopt adopt VB cord-015306-us58wwmp 2486 4 different different JJ cord-015306-us58wwmp 2486 5 treatment treatment NN cord-015306-us58wwmp 2486 6 strategy strategy NN cord-015306-us58wwmp 2486 7 according accord VBG cord-015306-us58wwmp 2486 8 to to IN cord-015306-us58wwmp 2486 9 different different JJ cord-015306-us58wwmp 2486 10 causes cause NNS cord-015306-us58wwmp 2486 11 and and CC cord-015306-us58wwmp 2487 1 the the DT cord-015306-us58wwmp 2487 2 short short JJ cord-015306-us58wwmp 2487 3 term term NN cord-015306-us58wwmp 2487 4 prognosis prognosis NN cord-015306-us58wwmp 2487 5 is be VBZ cord-015306-us58wwmp 2487 6 good good JJ cord-015306-us58wwmp 2487 7 . . . cord-015306-us58wwmp 2488 1 Abstract abstract JJ cord-015306-us58wwmp 2488 2 # # NN cord-015306-us58wwmp 2489 1 P p NN cord-015306-us58wwmp 2489 2 - - , cord-015306-us58wwmp 2489 3 SAT307 SAT307 NNP cord-015306-us58wwmp 2489 4 Biopsy Biopsy NNP cord-015306-us58wwmp 2489 5 proven prove VBD cord-015306-us58wwmp 2489 6 acute acute JJ cord-015306-us58wwmp 2489 7 interstitial interstitial JJ cord-015306-us58wwmp 2489 8 nephritis nephritis NN cord-015306-us58wwmp 2489 9 in in IN cord-015306-us58wwmp 2489 10 children child NNS cord-015306-us58wwmp 2490 1 Objective objective NN cord-015306-us58wwmp 2490 2 : : : cord-015306-us58wwmp 2491 1 Biopsy Biopsy NNP cord-015306-us58wwmp 2491 2 proven prove VBD cord-015306-us58wwmp 2491 3 acute acute JJ cord-015306-us58wwmp 2491 4 interstitial interstitial JJ cord-015306-us58wwmp 2491 5 nephritis nephritis NN cord-015306-us58wwmp 2491 6 ( ( -LRB- cord-015306-us58wwmp 2491 7 AIN AIN NNP cord-015306-us58wwmp 2491 8 ) ) -RRB- cord-015306-us58wwmp 2492 1 is be VBZ cord-015306-us58wwmp 2492 2 an an DT cord-015306-us58wwmp 2492 3 uncommon uncommon JJ cord-015306-us58wwmp 2492 4 cause cause NN cord-015306-us58wwmp 2492 5 of of IN cord-015306-us58wwmp 2492 6 acute acute JJ cord-015306-us58wwmp 2492 7 renal renal JJ cord-015306-us58wwmp 2492 8 failure failure NN cord-015306-us58wwmp 2492 9 in in IN cord-015306-us58wwmp 2492 10 children child NNS cord-015306-us58wwmp 2492 11 . . . cord-015306-us58wwmp 2493 1 The the DT cord-015306-us58wwmp 2493 2 cause cause NN cord-015306-us58wwmp 2493 3 of of IN cord-015306-us58wwmp 2493 4 AIN AIN NNP cord-015306-us58wwmp 2493 5 most most RBS cord-015306-us58wwmp 2493 6 is be VBZ cord-015306-us58wwmp 2493 7 commonly commonly RB cord-015306-us58wwmp 2493 8 due due JJ cord-015306-us58wwmp 2493 9 to to IN cord-015306-us58wwmp 2493 10 medications medication NNS cord-015306-us58wwmp 2493 11 such such JJ cord-015306-us58wwmp 2493 12 as as IN cord-015306-us58wwmp 2493 13 antibiotics antibiotic NNS cord-015306-us58wwmp 2493 14 or or CC cord-015306-us58wwmp 2493 15 infections infection NNS cord-015306-us58wwmp 2493 16 . . . cord-015306-us58wwmp 2494 1 We -PRON- PRP cord-015306-us58wwmp 2494 2 reviewed review VBD cord-015306-us58wwmp 2494 3 our -PRON- PRP$ cord-015306-us58wwmp 2494 4 experience experience NN cord-015306-us58wwmp 2494 5 of of IN cord-015306-us58wwmp 2494 6 biopsy biopsy NN cord-015306-us58wwmp 2494 7 proven prove VBN cord-015306-us58wwmp 2494 8 AIN AIN NNP cord-015306-us58wwmp 2494 9 in in IN cord-015306-us58wwmp 2494 10 children child NNS cord-015306-us58wwmp 2494 11 . . . cord-015306-us58wwmp 2495 1 The the DT cord-015306-us58wwmp 2495 2 biopsy biopsy NN cord-015306-us58wwmp 2495 3 database database NN cord-015306-us58wwmp 2495 4 of of IN cord-015306-us58wwmp 2495 5 all all DT cord-015306-us58wwmp 2495 6 native native JJ cord-015306-us58wwmp 2495 7 renal renal JJ cord-015306-us58wwmp 2495 8 biopsies biopsy NNS cord-015306-us58wwmp 2495 9 over over IN cord-015306-us58wwmp 2495 10 a a DT cord-015306-us58wwmp 2495 11 15 15 CD cord-015306-us58wwmp 2495 12 year year NN cord-015306-us58wwmp 2495 13 period period NN cord-015306-us58wwmp 2495 14 was be VBD cord-015306-us58wwmp 2495 15 reviewed review VBN cord-015306-us58wwmp 2495 16 . . . cord-015306-us58wwmp 2496 1 All all DT cord-015306-us58wwmp 2496 2 biopsies biopsy NNS cord-015306-us58wwmp 2496 3 which which WDT cord-015306-us58wwmp 2496 4 listed list VBD cord-015306-us58wwmp 2496 5 acute acute JJ cord-015306-us58wwmp 2496 6 interstitial interstitial JJ cord-015306-us58wwmp 2496 7 nephritis nephritis NN cord-015306-us58wwmp 2496 8 were be VBD cord-015306-us58wwmp 2496 9 selected select VBN cord-015306-us58wwmp 2496 10 and and CC cord-015306-us58wwmp 2496 11 clinical clinical JJ cord-015306-us58wwmp 2496 12 and and CC cord-015306-us58wwmp 2496 13 laboratory laboratory NN cord-015306-us58wwmp 2496 14 data datum NNS cord-015306-us58wwmp 2496 15 were be VBD cord-015306-us58wwmp 2496 16 extracted extract VBN cord-015306-us58wwmp 2496 17 from from IN cord-015306-us58wwmp 2496 18 clinical clinical JJ cord-015306-us58wwmp 2496 19 records record NNS cord-015306-us58wwmp 2496 20 . . . cord-015306-us58wwmp 2497 1 Results result NNS cord-015306-us58wwmp 2497 2 : : : cord-015306-us58wwmp 2497 3 16 16 CD cord-015306-us58wwmp 2497 4 cases case NNS cord-015306-us58wwmp 2497 5 of of IN cord-015306-us58wwmp 2497 6 AIN AIN NNP cord-015306-us58wwmp 2497 7 from from IN cord-015306-us58wwmp 2497 8 540 540 CD cord-015306-us58wwmp 2497 9 biopsies,(2.9 biopsies,(2.9 NNP cord-015306-us58wwmp 2497 10 % % NN cord-015306-us58wwmp 2497 11 ) ) -RRB- cord-015306-us58wwmp 2497 12 was be VBD cord-015306-us58wwmp 2497 13 identified identify VBN cord-015306-us58wwmp 2497 14 . . . cord-015306-us58wwmp 2498 1 Median median JJ cord-015306-us58wwmp 2498 2 age age NN cord-015306-us58wwmp 2498 3 11.5 11.5 CD cord-015306-us58wwmp 2498 4 years year NNS cord-015306-us58wwmp 2498 5 , , , cord-015306-us58wwmp 2498 6 range range VBP cord-015306-us58wwmp 2498 7 1 1 CD cord-015306-us58wwmp 2498 8 - - SYM cord-015306-us58wwmp 2498 9 14 14 CD cord-015306-us58wwmp 2498 10 12/16 12/16 CD cord-015306-us58wwmp 2498 11 cases case NNS cord-015306-us58wwmp 2498 12 presented present VBN cord-015306-us58wwmp 2498 13 with with IN cord-015306-us58wwmp 2498 14 acute acute JJ cord-015306-us58wwmp 2498 15 renal renal JJ cord-015306-us58wwmp 2498 16 failure failure NN cord-015306-us58wwmp 2498 17 without without IN cord-015306-us58wwmp 2498 18 an an DT cord-015306-us58wwmp 2498 19 obvious obvious JJ cord-015306-us58wwmp 2498 20 cause cause NN cord-015306-us58wwmp 2498 21 . . . cord-015306-us58wwmp 2499 1 13/16 13/16 CD cord-015306-us58wwmp 2499 2 cases case NNS cord-015306-us58wwmp 2499 3 had have VBD cord-015306-us58wwmp 2499 4 non non JJ cord-015306-us58wwmp 2499 5 specific specific JJ cord-015306-us58wwmp 2499 6 constitutional constitutional JJ cord-015306-us58wwmp 2499 7 symptoms symptom NNS cord-015306-us58wwmp 2499 8 and and CC cord-015306-us58wwmp 2499 9 oliguria oliguria NNP cord-015306-us58wwmp 2499 10 was be VBD cord-015306-us58wwmp 2499 11 reported report VBN cord-015306-us58wwmp 2499 12 by by IN cord-015306-us58wwmp 2499 13 6 6 CD cord-015306-us58wwmp 2499 14 patients patient NNS cord-015306-us58wwmp 2499 15 . . . cord-015306-us58wwmp 2500 1 Antibiotics antibiotic NNS cord-015306-us58wwmp 2500 2 were be VBD cord-015306-us58wwmp 2500 3 the the DT cord-015306-us58wwmp 2500 4 most most RBS cord-015306-us58wwmp 2500 5 common common JJ cord-015306-us58wwmp 2500 6 medications medication NNS cord-015306-us58wwmp 2500 7 implicated implicate VBN cord-015306-us58wwmp 2500 8 ( ( -LRB- cord-015306-us58wwmp 2500 9 5/16 5/16 CD cord-015306-us58wwmp 2500 10 patients patient NNS cord-015306-us58wwmp 2500 11 ) ) -RRB- cord-015306-us58wwmp 2501 1 Three three CD cord-015306-us58wwmp 2501 2 patients patient NNS cord-015306-us58wwmp 2501 3 were be VBD cord-015306-us58wwmp 2501 4 on on IN cord-015306-us58wwmp 2501 5 multiple multiple JJ cord-015306-us58wwmp 2501 6 medications medication NNS cord-015306-us58wwmp 2501 7 with with IN cord-015306-us58wwmp 2501 8 one one CD cord-015306-us58wwmp 2501 9 having have VBG cord-015306-us58wwmp 2501 10 chronic chronic JJ cord-015306-us58wwmp 2501 11 epilepsy epilepsy NN cord-015306-us58wwmp 2501 12 and and CC cord-015306-us58wwmp 2501 13 the the DT cord-015306-us58wwmp 2501 14 other other JJ cord-015306-us58wwmp 2501 15 Crohn Crohn NNP cord-015306-us58wwmp 2501 16 's 's POS cord-015306-us58wwmp 2501 17 disease disease NN cord-015306-us58wwmp 2501 18 . . . cord-015306-us58wwmp 2502 1 Five five CD cord-015306-us58wwmp 2502 2 patients patient NNS cord-015306-us58wwmp 2502 3 required require VBD cord-015306-us58wwmp 2502 4 short short JJ cord-015306-us58wwmp 2502 5 term term NN cord-015306-us58wwmp 2502 6 dialysis dialysis NN cord-015306-us58wwmp 2502 7 ranging range VBG cord-015306-us58wwmp 2502 8 from from IN cord-015306-us58wwmp 2502 9 2 2 CD cord-015306-us58wwmp 2502 10 to to IN cord-015306-us58wwmp 2502 11 7 7 CD cord-015306-us58wwmp 2502 12 days.13 days.13 NNP cord-015306-us58wwmp 2502 13 patients patient NNS cord-015306-us58wwmp 2502 14 were be VBD cord-015306-us58wwmp 2502 15 treated treat VBN cord-015306-us58wwmp 2502 16 with with IN cord-015306-us58wwmp 2502 17 corticosteroids corticosteroid NNS cord-015306-us58wwmp 2502 18 and and CC cord-015306-us58wwmp 2502 19 at at IN cord-015306-us58wwmp 2502 20 last last JJ cord-015306-us58wwmp 2502 21 follow follow VB cord-015306-us58wwmp 2502 22 up up RP cord-015306-us58wwmp 2502 23 , , , cord-015306-us58wwmp 2502 24 4 4 CD cord-015306-us58wwmp 2502 25 had have VBD cord-015306-us58wwmp 2502 26 reduced reduce VBN cord-015306-us58wwmp 2502 27 GFR GFR NNP cord-015306-us58wwmp 2502 28 45 45 CD cord-015306-us58wwmp 2502 29 - - HYPH cord-015306-us58wwmp 2502 30 74ml 74ml NN cord-015306-us58wwmp 2502 31 / / SYM cord-015306-us58wwmp 2502 32 min/1.73 min/1.73 JJ cord-015306-us58wwmp 2502 33 m m CD cord-015306-us58wwmp 2502 34 2 2 CD cord-015306-us58wwmp 2502 35 . . . cord-015306-us58wwmp 2503 1 Conclusion conclusion NN cord-015306-us58wwmp 2503 2 : : : cord-015306-us58wwmp 2504 1 Acute acute JJ cord-015306-us58wwmp 2504 2 interstitial interstitial JJ cord-015306-us58wwmp 2504 3 nephritis nephritis NN cord-015306-us58wwmp 2504 4 is be VBZ cord-015306-us58wwmp 2504 5 uncommon uncommon JJ cord-015306-us58wwmp 2504 6 in in IN cord-015306-us58wwmp 2504 7 childhood childhood NN cord-015306-us58wwmp 2504 8 but but CC cord-015306-us58wwmp 2504 9 when when WRB cord-015306-us58wwmp 2504 10 it -PRON- PRP cord-015306-us58wwmp 2504 11 occurs occur VBZ cord-015306-us58wwmp 2504 12 , , , cord-015306-us58wwmp 2504 13 antibiotics antibiotic NNS cord-015306-us58wwmp 2504 14 are be VBP cord-015306-us58wwmp 2504 15 the the DT cord-015306-us58wwmp 2504 16 single single JJ cord-015306-us58wwmp 2504 17 commonest common JJS cord-015306-us58wwmp 2504 18 cause cause NN cord-015306-us58wwmp 2504 19 . . . cord-015306-us58wwmp 2505 1 There there EX cord-015306-us58wwmp 2505 2 is be VBZ cord-015306-us58wwmp 2505 3 significant significant JJ cord-015306-us58wwmp 2505 4 morbidity morbidity NN cord-015306-us58wwmp 2505 5 associated associate VBN cord-015306-us58wwmp 2505 6 with with IN cord-015306-us58wwmp 2505 7 the the DT cord-015306-us58wwmp 2505 8 illness illness NN cord-015306-us58wwmp 2505 9 with with IN cord-015306-us58wwmp 2505 10 not not RB cord-015306-us58wwmp 2505 11 all all DT cord-015306-us58wwmp 2505 12 patients patient NNS cord-015306-us58wwmp 2505 13 making make VBG cord-015306-us58wwmp 2505 14 a a DT cord-015306-us58wwmp 2505 15 full full JJ cord-015306-us58wwmp 2505 16 recovery recovery NN cord-015306-us58wwmp 2505 17 . . . cord-015306-us58wwmp 2506 1 Abstract abstract JJ cord-015306-us58wwmp 2506 2 # # NN cord-015306-us58wwmp 2506 3 P p NN cord-015306-us58wwmp 2506 4 - - HYPH cord-015306-us58wwmp 2506 5 SAT308 SAT308 NNP cord-015306-us58wwmp 2506 6 Acute acute JJ cord-015306-us58wwmp 2506 7 kidney kidney NN cord-015306-us58wwmp 2506 8 injury injury NN cord-015306-us58wwmp 2506 9 as as IN cord-015306-us58wwmp 2506 10 presentation presentation NN cord-015306-us58wwmp 2506 11 of of IN cord-015306-us58wwmp 2506 12 Burkitt Burkitt NNP cord-015306-us58wwmp 2506 13 's 's POS cord-015306-us58wwmp 2506 14 lymphoma lymphoma NN cord-015306-us58wwmp 2506 15 Eva Eva NNP cord-015306-us58wwmp 2506 16 Greta Greta NNP cord-015306-us58wwmp 2506 17 ter ter NN cord-015306-us58wwmp 2506 18 Haar Haar NNP cord-015306-us58wwmp 2506 19 1 1 CD cord-015306-us58wwmp 2506 20 , , , cord-015306-us58wwmp 2506 21 Anne Anne NNP cord-015306-us58wwmp 2506 22 Uyttebroeck Uyttebroeck NNP cord-015306-us58wwmp 2506 23 2 2 CD cord-015306-us58wwmp 2506 24 , , , cord-015306-us58wwmp 2506 25 Marleen Marleen NNP cord-015306-us58wwmp 2506 26 Renard Renard NNP cord-015306-us58wwmp 2506 27 2 2 CD cord-015306-us58wwmp 2506 28 , , , cord-015306-us58wwmp 2506 29 Veerle Veerle NNP cord-015306-us58wwmp 2506 30 Labarque Labarque NNP cord-015306-us58wwmp 2506 31 2 2 CD cord-015306-us58wwmp 2506 32 , , , cord-015306-us58wwmp 2506 33 Djalila Djalila NNP cord-015306-us58wwmp 2506 34 Mekahli Mekahli NNP cord-015306-us58wwmp 2506 35 1 1 CD cord-015306-us58wwmp 2506 36 1 1 CD cord-015306-us58wwmp 2506 37 Pediatric Pediatric NNP cord-015306-us58wwmp 2506 38 Nephorlogy Nephorlogy NNP cord-015306-us58wwmp 2506 39 , , , cord-015306-us58wwmp 2506 40 University University NNP cord-015306-us58wwmp 2506 41 Hospital Hospital NNP cord-015306-us58wwmp 2506 42 Leuven Leuven NNP cord-015306-us58wwmp 2506 43 , , , cord-015306-us58wwmp 2506 44 Leuven Leuven NNP cord-015306-us58wwmp 2506 45 , , , cord-015306-us58wwmp 2506 46 Belgium Belgium NNP cord-015306-us58wwmp 2506 47 2 2 CD cord-015306-us58wwmp 2506 48 Pediatric Pediatric NNP cord-015306-us58wwmp 2506 49 Hemato Hemato NNP cord-015306-us58wwmp 2506 50 - - HYPH cord-015306-us58wwmp 2506 51 Oncology Oncology NNP cord-015306-us58wwmp 2506 52 , , , cord-015306-us58wwmp 2506 53 University University NNP cord-015306-us58wwmp 2506 54 Hospitals Hospitals NNPS cord-015306-us58wwmp 2506 55 Leuven Leuven NNP cord-015306-us58wwmp 2506 56 , , , cord-015306-us58wwmp 2507 1 Belgium Belgium NNP cord-015306-us58wwmp 2507 2 Objective Objective NNP cord-015306-us58wwmp 2507 3 : : : cord-015306-us58wwmp 2507 4 Acute acute JJ cord-015306-us58wwmp 2507 5 kidney kidney NN cord-015306-us58wwmp 2507 6 injury injury NN cord-015306-us58wwmp 2507 7 ( ( -LRB- cord-015306-us58wwmp 2507 8 AKI AKI NNP cord-015306-us58wwmp 2507 9 ) ) -RRB- cord-015306-us58wwmp 2507 10 has have VBZ cord-015306-us58wwmp 2507 11 become become VBN cord-015306-us58wwmp 2507 12 increasingly increasingly RB cord-015306-us58wwmp 2507 13 prevalent prevalent JJ cord-015306-us58wwmp 2507 14 . . . cord-015306-us58wwmp 2508 1 Approximately approximately RB cord-015306-us58wwmp 2508 2 2 2 CD cord-015306-us58wwmp 2508 3 - - SYM cord-015306-us58wwmp 2508 4 3 3 CD cord-015306-us58wwmp 2508 5 % % NN cord-015306-us58wwmp 2508 6 of of IN cord-015306-us58wwmp 2508 7 children child NNS cord-015306-us58wwmp 2508 8 admitted admit VBN cord-015306-us58wwmp 2508 9 to to IN cord-015306-us58wwmp 2508 10 pediatric pediatric JJ cord-015306-us58wwmp 2508 11 tertiary tertiary JJ cord-015306-us58wwmp 2508 12 care care NN cord-015306-us58wwmp 2508 13 centers center NNS cord-015306-us58wwmp 2508 14 present present JJ cord-015306-us58wwmp 2508 15 with with IN cord-015306-us58wwmp 2508 16 this this DT cord-015306-us58wwmp 2508 17 life life NN cord-015306-us58wwmp 2508 18 - - HYPH cord-015306-us58wwmp 2508 19 threatening threaten VBG cord-015306-us58wwmp 2508 20 condition condition NN cord-015306-us58wwmp 2508 21 . . . cord-015306-us58wwmp 2509 1 The the DT cord-015306-us58wwmp 2509 2 most most RBS cord-015306-us58wwmp 2509 3 common common JJ cord-015306-us58wwmp 2509 4 causes cause NNS cord-015306-us58wwmp 2509 5 are be VBP cord-015306-us58wwmp 2509 6 post post JJ cord-015306-us58wwmp 2509 7 - - JJ cord-015306-us58wwmp 2509 8 operative operative JJ cord-015306-us58wwmp 2509 9 septic septic JJ cord-015306-us58wwmp 2509 10 shock shock NN cord-015306-us58wwmp 2509 11 , , , cord-015306-us58wwmp 2509 12 organ organ NN cord-015306-us58wwmp 2509 13 or or CC cord-015306-us58wwmp 2509 14 bone bone NN cord-015306-us58wwmp 2509 15 marrow marrow NN cord-015306-us58wwmp 2509 16 transplantations transplantation NNS cord-015306-us58wwmp 2509 17 and and CC cord-015306-us58wwmp 2509 18 intrinsic intrinsic JJ cord-015306-us58wwmp 2509 19 renal renal JJ cord-015306-us58wwmp 2509 20 disease disease NN cord-015306-us58wwmp 2509 21 . . . cord-015306-us58wwmp 2510 1 The the DT cord-015306-us58wwmp 2510 2 latter latter JJ cord-015306-us58wwmp 2510 3 comprises comprise VBZ cord-015306-us58wwmp 2510 4 multiple multiple JJ cord-015306-us58wwmp 2510 5 disorders disorder NNS cord-015306-us58wwmp 2510 6 , , , cord-015306-us58wwmp 2510 7 but but CC cord-015306-us58wwmp 2510 8 tumor tumor NN cord-015306-us58wwmp 2510 9 invasion invasion NN cord-015306-us58wwmp 2510 10 due due IN cord-015306-us58wwmp 2510 11 to to IN cord-015306-us58wwmp 2510 12 a a DT cord-015306-us58wwmp 2510 13 lymphoproliferative lymphoproliferative JJ cord-015306-us58wwmp 2510 14 malignancy malignancy NN cord-015306-us58wwmp 2510 15 is be VBZ cord-015306-us58wwmp 2510 16 very very RB cord-015306-us58wwmp 2510 17 exceptional exceptional JJ cord-015306-us58wwmp 2510 18 . . . cord-015306-us58wwmp 2511 1 Methods method NNS cord-015306-us58wwmp 2511 2 and and CC cord-015306-us58wwmp 2511 3 Results result NNS cord-015306-us58wwmp 2512 1 : : : cord-015306-us58wwmp 2512 2 We -PRON- PRP cord-015306-us58wwmp 2512 3 report report VBP cord-015306-us58wwmp 2512 4 two two CD cord-015306-us58wwmp 2512 5 cases case NNS cord-015306-us58wwmp 2512 6 of of IN cord-015306-us58wwmp 2512 7 AKI AKI NNP cord-015306-us58wwmp 2512 8 caused cause VBN cord-015306-us58wwmp 2512 9 by by IN cord-015306-us58wwmp 2512 10 infiltration infiltration NN cord-015306-us58wwmp 2512 11 of of IN cord-015306-us58wwmp 2512 12 Burkitt Burkitt NNP cord-015306-us58wwmp 2512 13 's 's POS cord-015306-us58wwmp 2512 14 lymphoma lymphoma NN cord-015306-us58wwmp 2512 15 . . . cord-015306-us58wwmp 2513 1 Both both DT cord-015306-us58wwmp 2513 2 four four CD cord-015306-us58wwmp 2513 3 - - HYPH cord-015306-us58wwmp 2513 4 year year NN cord-015306-us58wwmp 2513 5 - - HYPH cord-015306-us58wwmp 2513 6 old old JJ cord-015306-us58wwmp 2513 7 male male JJ cord-015306-us58wwmp 2513 8 patients patient NNS cord-015306-us58wwmp 2513 9 presented present VBN cord-015306-us58wwmp 2513 10 with with IN cord-015306-us58wwmp 2513 11 abdominal abdominal JJ cord-015306-us58wwmp 2513 12 pain pain NN cord-015306-us58wwmp 2513 13 , , , cord-015306-us58wwmp 2513 14 nausea nausea NN cord-015306-us58wwmp 2513 15 , , , cord-015306-us58wwmp 2513 16 vomiting vomiting NN cord-015306-us58wwmp 2513 17 , , , cord-015306-us58wwmp 2513 18 weight weight NN cord-015306-us58wwmp 2513 19 loss loss NN cord-015306-us58wwmp 2513 20 and and CC cord-015306-us58wwmp 2513 21 overall overall JJ cord-015306-us58wwmp 2513 22 weakness weakness NN cord-015306-us58wwmp 2513 23 since since IN cord-015306-us58wwmp 2513 24 a a DT cord-015306-us58wwmp 2513 25 few few JJ cord-015306-us58wwmp 2513 26 weeks week NNS cord-015306-us58wwmp 2513 27 . . . cord-015306-us58wwmp 2514 1 Clinical clinical JJ cord-015306-us58wwmp 2514 2 examination examination NN cord-015306-us58wwmp 2514 3 showed show VBD cord-015306-us58wwmp 2514 4 hepatosplenomegaly hepatosplenomegaly NNP cord-015306-us58wwmp 2514 5 and and CC cord-015306-us58wwmp 2514 6 impressive impressive JJ cord-015306-us58wwmp 2514 7 bilateral bilateral JJ cord-015306-us58wwmp 2514 8 nephromegaly nephromegaly NN cord-015306-us58wwmp 2514 9 . . . cord-015306-us58wwmp 2515 1 Both both DT cord-015306-us58wwmp 2515 2 had have VBD cord-015306-us58wwmp 2515 3 malignant malignant JJ cord-015306-us58wwmp 2515 4 hypertension hypertension NN cord-015306-us58wwmp 2515 5 . . . cord-015306-us58wwmp 2516 1 Blood blood NN cord-015306-us58wwmp 2516 2 analysis analysis NN cord-015306-us58wwmp 2516 3 showed show VBD cord-015306-us58wwmp 2516 4 severe severe JJ cord-015306-us58wwmp 2516 5 renal renal JJ cord-015306-us58wwmp 2516 6 impairment impairment NN cord-015306-us58wwmp 2516 7 in in IN cord-015306-us58wwmp 2516 8 both both DT cord-015306-us58wwmp 2516 9 patients patient NNS cord-015306-us58wwmp 2516 10 . . . cord-015306-us58wwmp 2517 1 The the DT cord-015306-us58wwmp 2517 2 first first JJ cord-015306-us58wwmp 2517 3 had have VBD cord-015306-us58wwmp 2517 4 creatinine creatinine NN cord-015306-us58wwmp 2517 5 of of IN cord-015306-us58wwmp 2517 6 2.9 2.9 CD cord-015306-us58wwmp 2517 7 mg mg NNP cord-015306-us58wwmp 2517 8 / / SYM cord-015306-us58wwmp 2517 9 dL dL NNP cord-015306-us58wwmp 2517 10 ( ( -LRB- cord-015306-us58wwmp 2517 11 eGFR egfr NN cord-015306-us58wwmp 2517 12 21 21 CD cord-015306-us58wwmp 2517 13 ml ml NN cord-015306-us58wwmp 2517 14 / / SYM cord-015306-us58wwmp 2517 15 min/1.73 min/1.73 JJ cord-015306-us58wwmp 2517 16 m m CD cord-015306-us58wwmp 2517 17 2 2 CD cord-015306-us58wwmp 2517 18 ) ) -RRB- cord-015306-us58wwmp 2517 19 , , , cord-015306-us58wwmp 2517 20 urea urea NN cord-015306-us58wwmp 2517 21 of of IN cord-015306-us58wwmp 2517 22 97 97 CD cord-015306-us58wwmp 2517 23 mg mg NNP cord-015306-us58wwmp 2517 24 / / SYM cord-015306-us58wwmp 2517 25 dL dl NN cord-015306-us58wwmp 2517 26 and and CC cord-015306-us58wwmp 2517 27 uric uric JJ cord-015306-us58wwmp 2517 28 acid acid NN cord-015306-us58wwmp 2517 29 of of IN cord-015306-us58wwmp 2517 30 8.9 8.9 CD cord-015306-us58wwmp 2517 31 mg mg CD cord-015306-us58wwmp 2518 1 / / NFP cord-015306-us58wwmp 2519 1 dL. dL. NNP cord-015306-us58wwmp 2520 1 The the DT cord-015306-us58wwmp 2520 2 second second JJ cord-015306-us58wwmp 2520 3 had have VBD cord-015306-us58wwmp 2520 4 creatinine creatinine NN cord-015306-us58wwmp 2520 5 of of IN cord-015306-us58wwmp 2520 6 5.97mg 5.97mg CD cord-015306-us58wwmp 2520 7 / / SYM cord-015306-us58wwmp 2520 8 dL dl NN cord-015306-us58wwmp 2520 9 ( ( -LRB- cord-015306-us58wwmp 2520 10 eGFR egfr NN cord-015306-us58wwmp 2520 11 10 10 CD cord-015306-us58wwmp 2520 12 ml ml NN cord-015306-us58wwmp 2520 13 / / SYM cord-015306-us58wwmp 2520 14 min/1.73 min/1.73 JJ cord-015306-us58wwmp 2520 15 m m CD cord-015306-us58wwmp 2520 16 2 2 CD cord-015306-us58wwmp 2520 17 ) ) -RRB- cord-015306-us58wwmp 2520 18 , , , cord-015306-us58wwmp 2520 19 urea urea NN cord-015306-us58wwmp 2520 20 of of IN cord-015306-us58wwmp 2520 21 215mg 215mg NNP cord-015306-us58wwmp 2520 22 / / SYM cord-015306-us58wwmp 2520 23 dL dl NN cord-015306-us58wwmp 2520 24 and and CC cord-015306-us58wwmp 2520 25 uric uric JJ cord-015306-us58wwmp 2520 26 acid acid NN cord-015306-us58wwmp 2520 27 of of IN cord-015306-us58wwmp 2520 28 12mg/ 12mg/ CD cord-015306-us58wwmp 2521 1 dL. dL. NNP cord-015306-us58wwmp 2521 2 Lactate Lactate NNP cord-015306-us58wwmp 2521 3 dehydrogenase dehydrogenase NN cord-015306-us58wwmp 2521 4 was be VBD cord-015306-us58wwmp 2521 5 extremely extremely RB cord-015306-us58wwmp 2521 6 elevated elevated JJ cord-015306-us58wwmp 2521 7 in in IN cord-015306-us58wwmp 2521 8 both both DT cord-015306-us58wwmp 2521 9 cases case NNS cord-015306-us58wwmp 2522 1 ( ( -LRB- cord-015306-us58wwmp 2522 2 5860 5860 CD cord-015306-us58wwmp 2522 3 U U NNP cord-015306-us58wwmp 2522 4 / / SYM cord-015306-us58wwmp 2522 5 L l NN cord-015306-us58wwmp 2522 6 ; ; : cord-015306-us58wwmp 2522 7 758 758 CD cord-015306-us58wwmp 2522 8 U U NNP cord-015306-us58wwmp 2522 9 / / SYM cord-015306-us58wwmp 2522 10 L L NNP cord-015306-us58wwmp 2522 11 respectively respectively RB cord-015306-us58wwmp 2522 12 ) ) -RRB- cord-015306-us58wwmp 2522 13 . . . cord-015306-us58wwmp 2523 1 Urinary urinary JJ cord-015306-us58wwmp 2523 2 sediment sediment NN cord-015306-us58wwmp 2523 3 was be VBD cord-015306-us58wwmp 2523 4 normal normal JJ cord-015306-us58wwmp 2523 5 . . . cord-015306-us58wwmp 2524 1 Ultrasound ultrasound NN cord-015306-us58wwmp 2524 2 showed show VBD cord-015306-us58wwmp 2524 3 bilateral bilateral JJ cord-015306-us58wwmp 2524 4 nephromegaly nephromegaly NN cord-015306-us58wwmp 2524 5 in in IN cord-015306-us58wwmp 2524 6 both both DT cord-015306-us58wwmp 2524 7 patients patient NNS cord-015306-us58wwmp 2524 8 ( ( -LRB- cord-015306-us58wwmp 2524 9 Patient patient JJ cord-015306-us58wwmp 2524 10 1:+12SD 1:+12sd CD cord-015306-us58wwmp 2524 11 and and CC cord-015306-us58wwmp 2524 12 +11SD +11sd NN cord-015306-us58wwmp 2524 13 ; ; : cord-015306-us58wwmp 2524 14 Patient Patient NNP cord-015306-us58wwmp 2524 15 2 2 CD cord-015306-us58wwmp 2524 16 : : : cord-015306-us58wwmp 2525 1 +10SD +10sd FW cord-015306-us58wwmp 2525 2 and and CC cord-015306-us58wwmp 2525 3 +9SD +9SD NNP cord-015306-us58wwmp 2525 4 , , , cord-015306-us58wwmp 2525 5 for for IN cord-015306-us58wwmp 2525 6 right right NN cord-015306-us58wwmp 2525 7 and and CC cord-015306-us58wwmp 2525 8 left left JJ cord-015306-us58wwmp 2525 9 kidney kidney NN cord-015306-us58wwmp 2525 10 respectively respectively RB cord-015306-us58wwmp 2525 11 ) ) -RRB- cord-015306-us58wwmp 2525 12 . . . cord-015306-us58wwmp 2526 1 MRI MRI NNP cord-015306-us58wwmp 2526 2 demonstrated demonstrate VBD cord-015306-us58wwmp 2526 3 a a DT cord-015306-us58wwmp 2526 4 homogenous homogenous JJ cord-015306-us58wwmp 2526 5 renal renal JJ cord-015306-us58wwmp 2526 6 enlargement enlargement NN cord-015306-us58wwmp 2526 7 with with IN cord-015306-us58wwmp 2526 8 features feature NNS cord-015306-us58wwmp 2526 9 of of IN cord-015306-us58wwmp 2526 10 an an DT cord-015306-us58wwmp 2526 11 infiltrative infiltrative JJ cord-015306-us58wwmp 2526 12 lesion lesion NN cord-015306-us58wwmp 2526 13 . . . cord-015306-us58wwmp 2527 1 Bone bone NN cord-015306-us58wwmp 2527 2 marrow marrow NN cord-015306-us58wwmp 2527 3 was be VBD cord-015306-us58wwmp 2527 4 inconclusive inconclusive JJ cord-015306-us58wwmp 2527 5 and and CC cord-015306-us58wwmp 2527 6 diagnosis diagnosis NN cord-015306-us58wwmp 2527 7 of of IN cord-015306-us58wwmp 2527 8 Burkitt Burkitt NNP cord-015306-us58wwmp 2527 9 's 's POS cord-015306-us58wwmp 2527 10 lymphoma lymphoma NN cord-015306-us58wwmp 2527 11 was be VBD cord-015306-us58wwmp 2527 12 confirmed confirm VBN cord-015306-us58wwmp 2527 13 by by IN cord-015306-us58wwmp 2527 14 a a DT cord-015306-us58wwmp 2527 15 renal renal JJ cord-015306-us58wwmp 2527 16 biopsy biopsy NN cord-015306-us58wwmp 2527 17 . . . cord-015306-us58wwmp 2528 1 After after IN cord-015306-us58wwmp 2528 2 starting start VBG cord-015306-us58wwmp 2528 3 chemotherapy chemotherapy NN cord-015306-us58wwmp 2528 4 according accord VBG cord-015306-us58wwmp 2528 5 to to IN cord-015306-us58wwmp 2528 6 the the DT cord-015306-us58wwmp 2528 7 Inter Inter NNP cord-015306-us58wwmp 2528 8 - - HYPH cord-015306-us58wwmp 2528 9 B B NNP cord-015306-us58wwmp 2528 10 - - HYPH cord-015306-us58wwmp 2528 11 NHL NHL NNP cord-015306-us58wwmp 2528 12 Ritux Ritux NNP cord-015306-us58wwmp 2528 13 2010 2010 CD cord-015306-us58wwmp 2528 14 protocol protocol NN cord-015306-us58wwmp 2528 15 , , , cord-015306-us58wwmp 2528 16 both both DT cord-015306-us58wwmp 2528 17 children child NNS cord-015306-us58wwmp 2528 18 developed develop VBD cord-015306-us58wwmp 2528 19 a a DT cord-015306-us58wwmp 2528 20 tumor tumor NN cord-015306-us58wwmp 2528 21 lysis lysis NN cord-015306-us58wwmp 2528 22 syndrome syndrome NN cord-015306-us58wwmp 2528 23 and and CC cord-015306-us58wwmp 2528 24 required require VBN cord-015306-us58wwmp 2528 25 hemodialysis hemodialysis NN cord-015306-us58wwmp 2528 26 . . . cord-015306-us58wwmp 2529 1 At at IN cord-015306-us58wwmp 2529 2 last last JJ cord-015306-us58wwmp 2529 3 follow follow NN cord-015306-us58wwmp 2529 4 - - HYPH cord-015306-us58wwmp 2529 5 up up NN cord-015306-us58wwmp 2529 6 both both DT cord-015306-us58wwmp 2529 7 children child NNS cord-015306-us58wwmp 2529 8 still still RB cord-015306-us58wwmp 2529 9 had have VBD cord-015306-us58wwmp 2529 10 hypertension hypertension NN cord-015306-us58wwmp 2529 11 . . . cord-015306-us58wwmp 2530 1 Nevertheless nevertheless RB cord-015306-us58wwmp 2530 2 , , , cord-015306-us58wwmp 2530 3 renal renal JJ cord-015306-us58wwmp 2530 4 size size NN cord-015306-us58wwmp 2530 5 and and CC cord-015306-us58wwmp 2530 6 function function NN cord-015306-us58wwmp 2530 7 were be VBD cord-015306-us58wwmp 2530 8 normalized normalize VBN cord-015306-us58wwmp 2530 9 . . . cord-015306-us58wwmp 2531 1 Conclusion conclusion NN cord-015306-us58wwmp 2531 2 : : : cord-015306-us58wwmp 2532 1 Lymphomatous lymphomatous JJ cord-015306-us58wwmp 2532 2 infiltration infiltration NN cord-015306-us58wwmp 2532 3 due due IN cord-015306-us58wwmp 2532 4 to to IN cord-015306-us58wwmp 2532 5 Burkitt Burkitt NNP cord-015306-us58wwmp 2532 6 's 's POS cord-015306-us58wwmp 2532 7 lymphoma lymphoma NN cord-015306-us58wwmp 2532 8 is be VBZ cord-015306-us58wwmp 2532 9 a a DT cord-015306-us58wwmp 2532 10 rare rare JJ cord-015306-us58wwmp 2532 11 cause cause NN cord-015306-us58wwmp 2532 12 of of IN cord-015306-us58wwmp 2532 13 AKI AKI NNP cord-015306-us58wwmp 2532 14 . . . cord-015306-us58wwmp 2533 1 However however RB cord-015306-us58wwmp 2533 2 , , , cord-015306-us58wwmp 2533 3 it -PRON- PRP cord-015306-us58wwmp 2533 4 should should MD cord-015306-us58wwmp 2533 5 be be VB cord-015306-us58wwmp 2533 6 considered consider VBN cord-015306-us58wwmp 2533 7 in in IN cord-015306-us58wwmp 2533 8 a a DT cord-015306-us58wwmp 2533 9 patient patient NN cord-015306-us58wwmp 2533 10 presenting present VBG cord-015306-us58wwmp 2533 11 with with IN cord-015306-us58wwmp 2533 12 unexplained unexplained JJ cord-015306-us58wwmp 2533 13 renal renal JJ cord-015306-us58wwmp 2533 14 failure failure NN cord-015306-us58wwmp 2533 15 and and CC cord-015306-us58wwmp 2533 16 bilateral bilateral JJ cord-015306-us58wwmp 2533 17 nephromegaly nephromegaly NN cord-015306-us58wwmp 2533 18 with with IN cord-015306-us58wwmp 2533 19 normal normal JJ cord-015306-us58wwmp 2533 20 urinary urinary JJ cord-015306-us58wwmp 2533 21 sediment sediment NN cord-015306-us58wwmp 2533 22 . . . cord-015306-us58wwmp 2534 1 Renal renal JJ cord-015306-us58wwmp 2534 2 biopsy biopsy NN cord-015306-us58wwmp 2534 3 may may MD cord-015306-us58wwmp 2534 4 be be VB cord-015306-us58wwmp 2534 5 needed need VBN cord-015306-us58wwmp 2534 6 to to TO cord-015306-us58wwmp 2534 7 confirm confirm VB cord-015306-us58wwmp 2534 8 diagnosis diagnosis NN cord-015306-us58wwmp 2534 9 . . . cord-015306-us58wwmp 2535 1 Abstract abstract JJ cord-015306-us58wwmp 2535 2 # # NN cord-015306-us58wwmp 2535 3 P p NN cord-015306-us58wwmp 2536 1 -SAT309 -SAT309 NNP cord-015306-us58wwmp 2536 2 Does do VBZ cord-015306-us58wwmp 2536 3 malnutrition malnutrition NN cord-015306-us58wwmp 2536 4 interact interact VBP cord-015306-us58wwmp 2536 5 with with IN cord-015306-us58wwmp 2536 6 acute acute JJ cord-015306-us58wwmp 2536 7 kidney kidney NN cord-015306-us58wwmp 2536 8 injury injury NN cord-015306-us58wwmp 2536 9 in in IN cord-015306-us58wwmp 2536 10 children child NNS cord-015306-us58wwmp 2536 11 ? ? . cord-015306-us58wwmp 2537 1 Objective objective NN cord-015306-us58wwmp 2537 2 : : : cord-015306-us58wwmp 2537 3 To to TO cord-015306-us58wwmp 2537 4 investigate investigate VB cord-015306-us58wwmp 2537 5 the the DT cord-015306-us58wwmp 2537 6 interaction interaction NN cord-015306-us58wwmp 2537 7 between between IN cord-015306-us58wwmp 2537 8 malnutrition malnutrition NN cord-015306-us58wwmp 2537 9 and and CC cord-015306-us58wwmp 2537 10 acute acute JJ cord-015306-us58wwmp 2537 11 kidney kidney NN cord-015306-us58wwmp 2537 12 injury injury NN cord-015306-us58wwmp 2537 13 ( ( -LRB- cord-015306-us58wwmp 2537 14 AKI AKI NNP cord-015306-us58wwmp 2537 15 ) ) -RRB- cord-015306-us58wwmp 2537 16 assessed assess VBN cord-015306-us58wwmp 2537 17 by by IN cord-015306-us58wwmp 2537 18 pRIFLE prifle JJ cord-015306-us58wwmp 2537 19 criteria criterion NNS cord-015306-us58wwmp 2537 20 and and CC cord-015306-us58wwmp 2537 21 to to TO cord-015306-us58wwmp 2537 22 assess assess VB cord-015306-us58wwmp 2537 23 the the DT cord-015306-us58wwmp 2537 24 effects effect NNS cord-015306-us58wwmp 2537 25 of of IN cord-015306-us58wwmp 2537 26 these these DT cord-015306-us58wwmp 2537 27 factors factor NNS cord-015306-us58wwmp 2537 28 on on IN cord-015306-us58wwmp 2537 29 the the DT cord-015306-us58wwmp 2537 30 outcomes outcome NNS cord-015306-us58wwmp 2537 31 of of IN cord-015306-us58wwmp 2537 32 pediatric pediatric JJ cord-015306-us58wwmp 2537 33 intensive intensive JJ cord-015306-us58wwmp 2537 34 care care NN cord-015306-us58wwmp 2537 35 unit unit NN cord-015306-us58wwmp 2537 36 ( ( -LRB- cord-015306-us58wwmp 2537 37 pICU pICU NNP cord-015306-us58wwmp 2537 38 ) ) -RRB- cord-015306-us58wwmp 2537 39 patients patient NNS cord-015306-us58wwmp 2537 40 . . . cord-015306-us58wwmp 2538 1 Methods method NNS cord-015306-us58wwmp 2538 2 : : : cord-015306-us58wwmp 2539 1 Prospective prospective JJ cord-015306-us58wwmp 2539 2 cohort cohort NN cord-015306-us58wwmp 2539 3 study study NN cord-015306-us58wwmp 2539 4 conducted conduct VBN cord-015306-us58wwmp 2539 5 on on IN cord-015306-us58wwmp 2539 6 children child NNS cord-015306-us58wwmp 2539 7 . . . cord-015306-us58wwmp 2540 1 Outcome outcome NN cord-015306-us58wwmp 2540 2 variables variable NNS cord-015306-us58wwmp 2540 3 : : : cord-015306-us58wwmp 2540 4 mortality mortality NN cord-015306-us58wwmp 2540 5 , , , cord-015306-us58wwmp 2540 6 need need VBP cord-015306-us58wwmp 2540 7 for for IN cord-015306-us58wwmp 2540 8 dialysis dialysis NN cord-015306-us58wwmp 2540 9 , , , cord-015306-us58wwmp 2540 10 pICU picu FW cord-015306-us58wwmp 2540 11 free free JJ cord-015306-us58wwmp 2540 12 days day NNS cord-015306-us58wwmp 2540 13 ( ( -LRB- cord-015306-us58wwmp 2540 14 the the DT cord-015306-us58wwmp 2540 15 number number NN cord-015306-us58wwmp 2540 16 of of IN cord-015306-us58wwmp 2540 17 days day NNS cord-015306-us58wwmp 2540 18 alive alive JJ cord-015306-us58wwmp 2540 19 from from IN cord-015306-us58wwmp 2540 20 ICU ICU NNP cord-015306-us58wwmp 2540 21 discharge discharge NN cord-015306-us58wwmp 2540 22 to to IN cord-015306-us58wwmp 2540 23 day day NN cord-015306-us58wwmp 2540 24 28 28 CD cord-015306-us58wwmp 2540 25 ) ) -RRB- cord-015306-us58wwmp 2540 26 and and CC cord-015306-us58wwmp 2540 27 ventilator ventilator NN cord-015306-us58wwmp 2540 28 - - HYPH cord-015306-us58wwmp 2540 29 free free JJ cord-015306-us58wwmp 2540 30 days day NNS cord-015306-us58wwmp 2540 31 ( ( -LRB- cord-015306-us58wwmp 2540 32 the the DT cord-015306-us58wwmp 2540 33 number number NN cord-015306-us58wwmp 2540 34 of of IN cord-015306-us58wwmp 2540 35 days day NNS cord-015306-us58wwmp 2540 36 alive alive JJ cord-015306-us58wwmp 2540 37 and and CC cord-015306-us58wwmp 2540 38 breathing breathe VBG cord-015306-us58wwmp 2540 39 without without IN cord-015306-us58wwmp 2540 40 assistance assistance NN cord-015306-us58wwmp 2540 41 from from IN cord-015306-us58wwmp 2540 42 admission admission NN cord-015306-us58wwmp 2540 43 to to IN cord-015306-us58wwmp 2540 44 day day NN cord-015306-us58wwmp 2540 45 28 28 CD cord-015306-us58wwmp 2540 46 ) ) -RRB- cord-015306-us58wwmp 2540 47 . . . cord-015306-us58wwmp 2541 1 Exposure exposure NN cord-015306-us58wwmp 2541 2 variables variable NNS cord-015306-us58wwmp 2541 3 : : : cord-015306-us58wwmp 2542 1 Malnutrition malnutrition NN cord-015306-us58wwmp 2542 2 on on IN cord-015306-us58wwmp 2542 3 admission admission NN cord-015306-us58wwmp 2542 4 ( ( -LRB- cord-015306-us58wwmp 2542 5 WHO who WP cord-015306-us58wwmp 2542 6 growth growth NN cord-015306-us58wwmp 2542 7 standards standard NNS cord-015306-us58wwmp 2542 8 ) ) -RRB- cord-015306-us58wwmp 2542 9 and and CC cord-015306-us58wwmp 2542 10 any any DT cord-015306-us58wwmp 2542 11 change change NN cord-015306-us58wwmp 2542 12 in in IN cord-015306-us58wwmp 2542 13 pRIFLE prifle JJ cord-015306-us58wwmp 2542 14 criteria criterion NNS cord-015306-us58wwmp 2542 15 during during IN cord-015306-us58wwmp 2542 16 the the DT cord-015306-us58wwmp 2542 17 first first JJ cord-015306-us58wwmp 2542 18 ICU ICU NNP cord-015306-us58wwmp 2542 19 14 14 CD cord-015306-us58wwmp 2542 20 days day NNS cord-015306-us58wwmp 2542 21 . . . cord-015306-us58wwmp 2543 1 Results result NNS cord-015306-us58wwmp 2543 2 : : : cord-015306-us58wwmp 2544 1 Of of IN cord-015306-us58wwmp 2544 2 98 98 CD cord-015306-us58wwmp 2544 3 patients patient NNS cord-015306-us58wwmp 2544 4 ( ( -LRB- cord-015306-us58wwmp 2544 5 median median JJ cord-015306-us58wwmp 2544 6 age age NN cord-015306-us58wwmp 2544 7 = = SYM cord-015306-us58wwmp 2544 8 19 19 CD cord-015306-us58wwmp 2544 9 IQR IQR NNP cord-015306-us58wwmp 2544 10 = = SYM cord-015306-us58wwmp 2544 11 50 50 CD cord-015306-us58wwmp 2544 12 months month NNS cord-015306-us58wwmp 2544 13 , , , cord-015306-us58wwmp 2544 14 35 35 CD cord-015306-us58wwmp 2544 15 girls girl NNS cord-015306-us58wwmp 2544 16 ) ) -RRB- cord-015306-us58wwmp 2544 17 enrolled enrol VBD cord-015306-us58wwmp 2544 18 , , , cord-015306-us58wwmp 2544 19 39 39 CD cord-015306-us58wwmp 2544 20 ( ( -LRB- cord-015306-us58wwmp 2544 21 40 40 CD cord-015306-us58wwmp 2544 22 % % NN cord-015306-us58wwmp 2544 23 ) ) -RRB- cord-015306-us58wwmp 2544 24 were be VBD cord-015306-us58wwmp 2544 25 malnourished malnourish VBN cord-015306-us58wwmp 2544 26 and and CC cord-015306-us58wwmp 2544 27 34 34 CD cord-015306-us58wwmp 2544 28 ( ( -LRB- cord-015306-us58wwmp 2544 29 35 35 CD cord-015306-us58wwmp 2544 30 % % NN cord-015306-us58wwmp 2544 31 ) ) -RRB- cord-015306-us58wwmp 2544 32 developed develop VBD cord-015306-us58wwmp 2544 33 AKI AKI NNP cord-015306-us58wwmp 2544 34 . . . cord-015306-us58wwmp 2545 1 Among among IN cord-015306-us58wwmp 2545 2 the the DT cord-015306-us58wwmp 2545 3 malnourished malnourished JJ cord-015306-us58wwmp 2545 4 , , , cord-015306-us58wwmp 2545 5 19/39 19/39 CD cord-015306-us58wwmp 2545 6 cases case NNS cord-015306-us58wwmp 2545 7 ( ( -LRB- cord-015306-us58wwmp 2545 8 49 49 CD cord-015306-us58wwmp 2545 9 % % NN cord-015306-us58wwmp 2545 10 ) ) -RRB- cord-015306-us58wwmp 2545 11 had have VBD cord-015306-us58wwmp 2545 12 AKI AKI NNP cord-015306-us58wwmp 2545 13 , , , cord-015306-us58wwmp 2545 14 while while IN cord-015306-us58wwmp 2545 15 this this DT cord-015306-us58wwmp 2545 16 complication complication NN cord-015306-us58wwmp 2545 17 occurred occur VBD cord-015306-us58wwmp 2545 18 in in IN cord-015306-us58wwmp 2545 19 15/59 15/59 CD cord-015306-us58wwmp 2545 20 ( ( -LRB- cord-015306-us58wwmp 2545 21 25 25 CD cord-015306-us58wwmp 2545 22 % % NN cord-015306-us58wwmp 2545 23 ) ) -RRB- cord-015306-us58wwmp 2545 24 of of IN cord-015306-us58wwmp 2545 25 patients patient NNS cord-015306-us58wwmp 2545 26 without without IN cord-015306-us58wwmp 2545 27 malnutrition malnutrition NN cord-015306-us58wwmp 2545 28 resulting result VBG cord-015306-us58wwmp 2545 29 in in IN cord-015306-us58wwmp 2545 30 a a DT cord-015306-us58wwmp 2545 31 risk risk NN cord-015306-us58wwmp 2545 32 ratio ratio NN cord-015306-us58wwmp 2545 33 of of IN cord-015306-us58wwmp 2545 34 1.9 1.9 CD cord-015306-us58wwmp 2545 35 ( ( -LRB- cord-015306-us58wwmp 2545 36 95%CI 95%ci CD cord-015306-us58wwmp 2545 37 1.1 1.1 CD cord-015306-us58wwmp 2545 38 -3.3 -3.3 CD cord-015306-us58wwmp 2545 39 ) ) -RRB- cord-015306-us58wwmp 2545 40 . . . cord-015306-us58wwmp 2546 1 The the DT cord-015306-us58wwmp 2546 2 28 28 CD cord-015306-us58wwmp 2546 3 days day NNS cord-015306-us58wwmp 2546 4 mortality mortality NN cord-015306-us58wwmp 2546 5 rate rate NN cord-015306-us58wwmp 2546 6 was be VBD cord-015306-us58wwmp 2546 7 10/98 10/98 CD cord-015306-us58wwmp 2546 8 cases case NNS cord-015306-us58wwmp 2546 9 ( ( -LRB- cord-015306-us58wwmp 2546 10 10 10 CD cord-015306-us58wwmp 2546 11 % % NN cord-015306-us58wwmp 2546 12 ) ) -RRB- cord-015306-us58wwmp 2546 13 and and CC cord-015306-us58wwmp 2546 14 AKI AKI NNP cord-015306-us58wwmp 2546 15 was be VBD cord-015306-us58wwmp 2546 16 associated associate VBN cord-015306-us58wwmp 2546 17 with with IN cord-015306-us58wwmp 2546 18 higher high JJR cord-015306-us58wwmp 2546 19 risk risk NN cord-015306-us58wwmp 2546 20 ( ( -LRB- cord-015306-us58wwmp 2546 21 8/34 8/34 CD cord-015306-us58wwmp 2546 22 versus versus IN cord-015306-us58wwmp 2546 23 2/64 2/64 CD cord-015306-us58wwmp 2546 24 cases case NNS cord-015306-us58wwmp 2547 1 -RR=7.5 -rr=7.5 XX cord-015306-us58wwmp 2548 1 95%CI 95%ci CD cord-015306-us58wwmp 2548 2 1.7 1.7 CD cord-015306-us58wwmp 2548 3 - - HYPH cord-015306-us58wwmp 2548 4 33.5 33.5 CD cord-015306-us58wwmp 2548 5 ) ) -RRB- cord-015306-us58wwmp 2548 6 . . . cord-015306-us58wwmp 2549 1 Concurrent concurrent JJ cord-015306-us58wwmp 2549 2 malnutrition malnutrition NN cord-015306-us58wwmp 2549 3 and and CC cord-015306-us58wwmp 2549 4 AKI AKI NNP cord-015306-us58wwmp 2549 5 was be VBD cord-015306-us58wwmp 2549 6 present present JJ cord-015306-us58wwmp 2549 7 in in IN cord-015306-us58wwmp 2549 8 19/98 19/98 CD cord-015306-us58wwmp 2549 9 cases case NNS cord-015306-us58wwmp 2549 10 ( ( -LRB- cord-015306-us58wwmp 2549 11 19 19 CD cord-015306-us58wwmp 2549 12 % % NN cord-015306-us58wwmp 2549 13 ) ) -RRB- cord-015306-us58wwmp 2549 14 producing produce VBG cord-015306-us58wwmp 2549 15 a a DT cord-015306-us58wwmp 2549 16 tendency tendency NN cord-015306-us58wwmp 2549 17 ( ( -LRB- cord-015306-us58wwmp 2549 18 p=0.2 p=0.2 NNP cord-015306-us58wwmp 2549 19 ) ) -RRB- cord-015306-us58wwmp 2549 20 to to IN cord-015306-us58wwmp 2549 21 a a DT cord-015306-us58wwmp 2549 22 further further JJ cord-015306-us58wwmp 2549 23 increased increase VBN cord-015306-us58wwmp 2549 24 risk risk NN cord-015306-us58wwmp 2549 25 of of IN cord-015306-us58wwmp 2549 26 death death NN cord-015306-us58wwmp 2550 1 ( ( -LRB- cord-015306-us58wwmp 2550 2 RR=9.4 rr=9.4 UH cord-015306-us58wwmp 2551 1 95%CI 95%ci CD cord-015306-us58wwmp 2551 2 1.5 1.5 CD cord-015306-us58wwmp 2551 3 - - HYPH cord-015306-us58wwmp 2551 4 58.0 58.0 CD cord-015306-us58wwmp 2551 5 ) ) -RRB- cord-015306-us58wwmp 2551 6 . . . cord-015306-us58wwmp 2552 1 9/98 9/98 CD cord-015306-us58wwmp 2552 2 ( ( -LRB- cord-015306-us58wwmp 2552 3 9 9 CD cord-015306-us58wwmp 2552 4 % % NN cord-015306-us58wwmp 2552 5 ) ) -RRB- cord-015306-us58wwmp 2552 6 patients patient NNS cord-015306-us58wwmp 2552 7 needed need VBD cord-015306-us58wwmp 2552 8 dialysis dialysis NN cord-015306-us58wwmp 2552 9 and and CC cord-015306-us58wwmp 2552 10 malnutrition malnutrition NN cord-015306-us58wwmp 2552 11 increased increase VBD cord-015306-us58wwmp 2552 12 the the DT cord-015306-us58wwmp 2552 13 risk risk NN cord-015306-us58wwmp 2552 14 for for IN cord-015306-us58wwmp 2552 15 this this DT cord-015306-us58wwmp 2552 16 outcome outcome NN cord-015306-us58wwmp 2552 17 ( ( -LRB- cord-015306-us58wwmp 2552 18 RR=5.3 rr=5.3 VB cord-015306-us58wwmp 2553 1 95%CI 95%ci CD cord-015306-us58wwmp 2553 2 1.2 1.2 CD cord-015306-us58wwmp 2553 3 - - SYM cord-015306-us58wwmp 2553 4 24.2 24.2 CD cord-015306-us58wwmp 2553 5 ) ) -RRB- cord-015306-us58wwmp 2553 6 . . . cord-015306-us58wwmp 2554 1 AKI AKI NNP cord-015306-us58wwmp 2554 2 was be VBD cord-015306-us58wwmp 2554 3 associated associate VBN cord-015306-us58wwmp 2554 4 with with IN cord-015306-us58wwmp 2554 5 significantly significantly RB cord-015306-us58wwmp 2554 6 higher high JJR cord-015306-us58wwmp 2554 7 ICU ICU NNP cord-015306-us58wwmp 2554 8 free free JJ cord-015306-us58wwmp 2554 9 days day NNS cord-015306-us58wwmp 2554 10 ( ( -LRB- cord-015306-us58wwmp 2554 11 19±7 19±7 CD cord-015306-us58wwmp 2554 12 vs. vs. IN cord-015306-us58wwmp 2554 13 15±10 15±10 LS cord-015306-us58wwmp 2554 14 ) ) -RRB- cord-015306-us58wwmp 2554 15 and and CC cord-015306-us58wwmp 2554 16 ventilator ventilator NN cord-015306-us58wwmp 2554 17 - - HYPH cord-015306-us58wwmp 2554 18 free free JJ cord-015306-us58wwmp 2554 19 days day NNS cord-015306-us58wwmp 2554 20 ( ( -LRB- cord-015306-us58wwmp 2554 21 22±9 22±9 CD cord-015306-us58wwmp 2554 22 vs. vs. FW cord-015306-us58wwmp 2554 23 13±12 13±12 CD cord-015306-us58wwmp 2554 24 ) ) -RRB- cord-015306-us58wwmp 2554 25 but but CC cord-015306-us58wwmp 2554 26 concomitant concomitant JJ cord-015306-us58wwmp 2554 27 malnutrition malnutrition NN cord-015306-us58wwmp 2554 28 did do VBD cord-015306-us58wwmp 2554 29 not not RB cord-015306-us58wwmp 2554 30 reduce reduce VB cord-015306-us58wwmp 2554 31 either either DT cord-015306-us58wwmp 2554 32 of of IN cord-015306-us58wwmp 2554 33 these these DT cord-015306-us58wwmp 2554 34 outcomes outcome NNS cord-015306-us58wwmp 2554 35 . . . cord-015306-us58wwmp 2555 1 Conclusion conclusion NN cord-015306-us58wwmp 2555 2 : : : cord-015306-us58wwmp 2556 1 Malnutrition malnutrition NN cord-015306-us58wwmp 2556 2 and and CC cord-015306-us58wwmp 2556 3 AKI AKI NNP cord-015306-us58wwmp 2556 4 are be VBP cord-015306-us58wwmp 2556 5 common common JJ cord-015306-us58wwmp 2556 6 in in IN cord-015306-us58wwmp 2556 7 children child NNS cord-015306-us58wwmp 2556 8 admitted admit VBN cord-015306-us58wwmp 2556 9 to to IN cord-015306-us58wwmp 2556 10 the the DT cord-015306-us58wwmp 2556 11 ICU ICU NNP cord-015306-us58wwmp 2556 12 and and CC cord-015306-us58wwmp 2556 13 the the DT cord-015306-us58wwmp 2556 14 presence presence NN cord-015306-us58wwmp 2556 15 of of IN cord-015306-us58wwmp 2556 16 malnutrition malnutrition NN cord-015306-us58wwmp 2556 17 is be VBZ cord-015306-us58wwmp 2556 18 associated associate VBN cord-015306-us58wwmp 2556 19 with with IN cord-015306-us58wwmp 2556 20 increased increase VBN cord-015306-us58wwmp 2556 21 risk risk NN cord-015306-us58wwmp 2556 22 of of IN cord-015306-us58wwmp 2556 23 developing develop VBG cord-015306-us58wwmp 2556 24 AKI AKI NNP cord-015306-us58wwmp 2556 25 . . . cord-015306-us58wwmp 2557 1 The the DT cord-015306-us58wwmp 2557 2 need need NN cord-015306-us58wwmp 2557 3 for for IN cord-015306-us58wwmp 2557 4 dialysis dialysis NN cord-015306-us58wwmp 2557 5 was be VBD cord-015306-us58wwmp 2557 6 increased increase VBN cord-015306-us58wwmp 2557 7 in in IN cord-015306-us58wwmp 2557 8 malnourished malnourished JJ cord-015306-us58wwmp 2557 9 patients patient NNS cord-015306-us58wwmp 2557 10 and and CC cord-015306-us58wwmp 2557 11 more more RBR cord-015306-us58wwmp 2557 12 powered powered JJ cord-015306-us58wwmp 2557 13 studies study NNS cord-015306-us58wwmp 2557 14 are be VBP cord-015306-us58wwmp 2557 15 demanded demand VBN cord-015306-us58wwmp 2557 16 to to TO cord-015306-us58wwmp 2557 17 test test VB cord-015306-us58wwmp 2557 18 whether whether IN cord-015306-us58wwmp 2557 19 the the DT cord-015306-us58wwmp 2557 20 tendency tendency NN cord-015306-us58wwmp 2557 21 to to IN cord-015306-us58wwmp 2557 22 higher high JJR cord-015306-us58wwmp 2557 23 mortality mortality NN cord-015306-us58wwmp 2557 24 observed observe VBN cord-015306-us58wwmp 2557 25 in in IN cord-015306-us58wwmp 2557 26 patients patient NNS cord-015306-us58wwmp 2557 27 with with IN cord-015306-us58wwmp 2557 28 concomitant concomitant JJ cord-015306-us58wwmp 2557 29 AKI AKI NNP cord-015306-us58wwmp 2557 30 and and CC cord-015306-us58wwmp 2557 31 malnutrition malnutrition NN cord-015306-us58wwmp 2557 32 is be VBZ cord-015306-us58wwmp 2557 33 confirmed confirm VBN cord-015306-us58wwmp 2557 34 . . . cord-015306-us58wwmp 2558 1 Urine urine NN cord-015306-us58wwmp 2558 2 erythropoietin erythropoietin NN cord-015306-us58wwmp 2558 3 level level NN cord-015306-us58wwmp 2558 4 is be VBZ cord-015306-us58wwmp 2558 5 associated associate VBN cord-015306-us58wwmp 2558 6 with with IN cord-015306-us58wwmp 2558 7 kidney kidney NN cord-015306-us58wwmp 2558 8 and and CC cord-015306-us58wwmp 2558 9 brain brain NN cord-015306-us58wwmp 2558 10 injury injury NN cord-015306-us58wwmp 2558 11 in in IN cord-015306-us58wwmp 2558 12 critically critically RB cord-015306-us58wwmp 2558 13 ill ill JJ cord-015306-us58wwmp 2558 14 neonates neonate NNS cord-015306-us58wwmp 2558 15 Yanhong Yanhong NNP cord-015306-us58wwmp 2558 16 Li Li NNP cord-015306-us58wwmp 2558 17 , , , cord-015306-us58wwmp 2558 18 Jie Jie NNP cord-015306-us58wwmp 2558 19 Yan Yan NNP cord-015306-us58wwmp 2558 20 , , , cord-015306-us58wwmp 2558 21 XiaoZhong XiaoZhong NNP cord-015306-us58wwmp 2558 22 Li Li NNP cord-015306-us58wwmp 2558 23 Department Department NNP cord-015306-us58wwmp 2558 24 of of IN cord-015306-us58wwmp 2558 25 nephrology nephrology NN cord-015306-us58wwmp 2558 26 , , , cord-015306-us58wwmp 2558 27 Children Children NNP cord-015306-us58wwmp 2558 28 's 's POS cord-015306-us58wwmp 2558 29 Hospital Hospital NNP cord-015306-us58wwmp 2558 30 affiliated affiliate VBN cord-015306-us58wwmp 2558 31 to to IN cord-015306-us58wwmp 2558 32 Soochow Soochow NNP cord-015306-us58wwmp 2558 33 University University NNP cord-015306-us58wwmp 2558 34 , , , cord-015306-us58wwmp 2558 35 SuZhou SuZhou NNP cord-015306-us58wwmp 2558 36 , , , cord-015306-us58wwmp 2559 1 China China NNP cord-015306-us58wwmp 2559 2 Objective Objective NNP cord-015306-us58wwmp 2559 3 : : : cord-015306-us58wwmp 2559 4 Erythropoietin Erythropoietin NNP cord-015306-us58wwmp 2559 5 ( ( -LRB- cord-015306-us58wwmp 2559 6 EPO EPO NNP cord-015306-us58wwmp 2559 7 ) ) -RRB- cord-015306-us58wwmp 2559 8 is be VBZ cord-015306-us58wwmp 2559 9 a a DT cord-015306-us58wwmp 2559 10 glycoprotein glycoprotein NN cord-015306-us58wwmp 2559 11 hormone hormone NN cord-015306-us58wwmp 2559 12 produced produce VBN cord-015306-us58wwmp 2559 13 predominantly predominantly RB cord-015306-us58wwmp 2559 14 in in IN cord-015306-us58wwmp 2559 15 the the DT cord-015306-us58wwmp 2559 16 kidneys kidney NNS cord-015306-us58wwmp 2559 17 . . . cord-015306-us58wwmp 2560 1 The the DT cord-015306-us58wwmp 2560 2 protective protective JJ cord-015306-us58wwmp 2560 3 effect effect NN cord-015306-us58wwmp 2560 4 of of IN cord-015306-us58wwmp 2560 5 exogenous exogenous JJ cord-015306-us58wwmp 2560 6 EPO EPO NNP cord-015306-us58wwmp 2560 7 in in IN cord-015306-us58wwmp 2560 8 hypoxic hypoxic JJ cord-015306-us58wwmp 2560 9 - - HYPH cord-015306-us58wwmp 2560 10 ischemic ischemic JJ cord-015306-us58wwmp 2560 11 brain brain NN cord-015306-us58wwmp 2560 12 injury injury NN cord-015306-us58wwmp 2560 13 has have VBZ cord-015306-us58wwmp 2560 14 been be VBN cord-015306-us58wwmp 2560 15 thoroughly thoroughly RB cord-015306-us58wwmp 2560 16 examined examine VBN cord-015306-us58wwmp 2560 17 in in IN cord-015306-us58wwmp 2560 18 neonates neonate NNS cord-015306-us58wwmp 2560 19 . . . cord-015306-us58wwmp 2561 1 However however RB cord-015306-us58wwmp 2561 2 , , , cord-015306-us58wwmp 2561 3 the the DT cord-015306-us58wwmp 2561 4 metabolism metabolism NN cord-015306-us58wwmp 2561 5 of of IN cord-015306-us58wwmp 2561 6 endogenous endogenous JJ cord-015306-us58wwmp 2561 7 EPO EPO NNP cord-015306-us58wwmp 2561 8 in in IN cord-015306-us58wwmp 2561 9 neonates neonate NNS cord-015306-us58wwmp 2561 10 remains remain VBZ cord-015306-us58wwmp 2561 11 unclear unclear JJ cord-015306-us58wwmp 2561 12 . . . cord-015306-us58wwmp 2562 1 We -PRON- PRP cord-015306-us58wwmp 2562 2 aimed aim VBD cord-015306-us58wwmp 2562 3 to to TO cord-015306-us58wwmp 2562 4 evaluate evaluate VB cord-015306-us58wwmp 2562 5 the the DT cord-015306-us58wwmp 2562 6 concentration concentration NN cord-015306-us58wwmp 2562 7 of of IN cord-015306-us58wwmp 2562 8 urinary urinary JJ cord-015306-us58wwmp 2562 9 EPO EPO NNP cord-015306-us58wwmp 2562 10 ( ( -LRB- cord-015306-us58wwmp 2562 11 uEPO uepo JJ cord-015306-us58wwmp 2562 12 ) ) -RRB- cord-015306-us58wwmp 2562 13 in in IN cord-015306-us58wwmp 2562 14 critically critically RB cord-015306-us58wwmp 2562 15 ill ill JJ cord-015306-us58wwmp 2562 16 neonates neonate NNS cord-015306-us58wwmp 2562 17 and and CC cord-015306-us58wwmp 2562 18 to to TO cord-015306-us58wwmp 2562 19 identify identify VB cord-015306-us58wwmp 2562 20 possible possible JJ cord-015306-us58wwmp 2562 21 clinical clinical JJ cord-015306-us58wwmp 2562 22 and and CC cord-015306-us58wwmp 2562 23 laboratory laboratory NN cord-015306-us58wwmp 2562 24 variables variable NNS cord-015306-us58wwmp 2562 25 that that WDT cord-015306-us58wwmp 2562 26 may may MD cord-015306-us58wwmp 2562 27 be be VB cord-015306-us58wwmp 2562 28 associated associate VBN cord-015306-us58wwmp 2562 29 with with IN cord-015306-us58wwmp 2562 30 uEPO uepo JJ cord-015306-us58wwmp 2562 31 levels level NNS cord-015306-us58wwmp 2562 32 . . . cord-015306-us58wwmp 2563 1 Methods method NNS cord-015306-us58wwmp 2563 2 : : : cord-015306-us58wwmp 2564 1 The the DT cord-015306-us58wwmp 2564 2 concentrations concentration NNS cord-015306-us58wwmp 2564 3 of of IN cord-015306-us58wwmp 2564 4 EPO EPO NNP cord-015306-us58wwmp 2564 5 , , , cord-015306-us58wwmp 2564 6 cystatin cystatin NN cord-015306-us58wwmp 2564 7 - - HYPH cord-015306-us58wwmp 2564 8 C C NNP cord-015306-us58wwmp 2564 9 , , , cord-015306-us58wwmp 2564 10 microalbumin microalbumin NNP cord-015306-us58wwmp 2564 11 , , , cord-015306-us58wwmp 2564 12 and and CC cord-015306-us58wwmp 2564 13 α α NN cord-015306-us58wwmp 2564 14 1 1 CD cord-015306-us58wwmp 2564 15 -microglobulin -microglobulin CD cord-015306-us58wwmp 2564 16 in in IN cord-015306-us58wwmp 2564 17 the the DT cord-015306-us58wwmp 2564 18 first first JJ cord-015306-us58wwmp 2564 19 available available JJ cord-015306-us58wwmp 2564 20 urine urine NN cord-015306-us58wwmp 2564 21 sample sample NN cord-015306-us58wwmp 2564 22 during during IN cord-015306-us58wwmp 2564 23 the the DT cord-015306-us58wwmp 2564 24 initial initial JJ cord-015306-us58wwmp 2564 25 72 72 CD cord-015306-us58wwmp 2564 26 hours hour NNS cord-015306-us58wwmp 2564 27 of of IN cord-015306-us58wwmp 2564 28 life life NN cord-015306-us58wwmp 2564 29 were be VBD cord-015306-us58wwmp 2564 30 measured measure VBN cord-015306-us58wwmp 2564 31 in in IN cord-015306-us58wwmp 2564 32 103 103 CD cord-015306-us58wwmp 2564 33 critically critically RB cord-015306-us58wwmp 2564 34 ill ill JJ cord-015306-us58wwmp 2564 35 neonates neonate NNS cord-015306-us58wwmp 2564 36 . . . cord-015306-us58wwmp 2565 1 Clinical clinical JJ cord-015306-us58wwmp 2565 2 and and CC cord-015306-us58wwmp 2565 3 laboratory laboratory NN cord-015306-us58wwmp 2565 4 data datum NNS cord-015306-us58wwmp 2565 5 were be VBD cord-015306-us58wwmp 2565 6 collected collect VBN cord-015306-us58wwmp 2565 7 for for IN cord-015306-us58wwmp 2565 8 each each DT cord-015306-us58wwmp 2565 9 neonate neonate NN cord-015306-us58wwmp 2565 10 . . . cord-015306-us58wwmp 2566 1 Results result NNS cord-015306-us58wwmp 2566 2 : : : cord-015306-us58wwmp 2567 1 There there EX cord-015306-us58wwmp 2567 2 was be VBD cord-015306-us58wwmp 2567 3 a a DT cord-015306-us58wwmp 2567 4 positive positive JJ cord-015306-us58wwmp 2567 5 correlation correlation NN cord-015306-us58wwmp 2567 6 between between IN cord-015306-us58wwmp 2567 7 uEPO uepo JJ cord-015306-us58wwmp 2567 8 levels level NNS cord-015306-us58wwmp 2567 9 and and CC cord-015306-us58wwmp 2567 10 urinary urinary JJ cord-015306-us58wwmp 2567 11 levels level NNS cord-015306-us58wwmp 2567 12 of of IN cord-015306-us58wwmp 2567 13 cystatin cystatin NN cord-015306-us58wwmp 2567 14 - - HYPH cord-015306-us58wwmp 2567 15 C c NN cord-015306-us58wwmp 2567 16 ( ( -LRB- cord-015306-us58wwmp 2567 17 r r NN cord-015306-us58wwmp 2567 18 = = SYM cord-015306-us58wwmp 2567 19 0.265 0.265 CD cord-015306-us58wwmp 2567 20 , , , cord-015306-us58wwmp 2567 21 p p NN cord-015306-us58wwmp 2567 22 = = SYM cord-015306-us58wwmp 2567 23 0.008 0.008 CD cord-015306-us58wwmp 2567 24 ) ) -RRB- cord-015306-us58wwmp 2567 25 , , , cord-015306-us58wwmp 2567 26 microalbumin microalbumin NNP cord-015306-us58wwmp 2567 27 ( ( -LRB- cord-015306-us58wwmp 2567 28 r r NN cord-015306-us58wwmp 2567 29 = = SYM cord-015306-us58wwmp 2567 30 0.422 0.422 CD cord-015306-us58wwmp 2567 31 , , , cord-015306-us58wwmp 2567 32 p p NN cord-015306-us58wwmp 2567 33 < < XX cord-015306-us58wwmp 2567 34 0.001 0.001 CD cord-015306-us58wwmp 2567 35 ) ) -RRB- cord-015306-us58wwmp 2567 36 , , , cord-015306-us58wwmp 2567 37 andα andα NNP cord-015306-us58wwmp 2567 38 1 1 CD cord-015306-us58wwmp 2567 39 -microglobulin -microglobulin CD cord-015306-us58wwmp 2568 1 ( ( -LRB- cord-015306-us58wwmp 2568 2 r r NN cord-015306-us58wwmp 2568 3 = = SYM cord-015306-us58wwmp 2568 4 0.421 0.421 CD cord-015306-us58wwmp 2568 5 , , , cord-015306-us58wwmp 2568 6 p p NN cord-015306-us58wwmp 2568 7 < < XX cord-015306-us58wwmp 2568 8 0.001 0.001 CD cord-015306-us58wwmp 2568 9 ) ) -RRB- cord-015306-us58wwmp 2568 10 . . . cord-015306-us58wwmp 2569 1 The the DT cord-015306-us58wwmp 2569 2 concentration concentration NN cord-015306-us58wwmp 2569 3 of of IN cord-015306-us58wwmp 2569 4 uEPO uEPO NNP cord-015306-us58wwmp 2569 5 was be VBD cord-015306-us58wwmp 2569 6 elevated elevate VBN cord-015306-us58wwmp 2569 7 in in IN cord-015306-us58wwmp 2569 8 neonates neonate NNS cord-015306-us58wwmp 2569 9 who who WP cord-015306-us58wwmp 2569 10 developed develop VBD cord-015306-us58wwmp 2569 11 acute acute JJ cord-015306-us58wwmp 2569 12 kidney kidney NN cord-015306-us58wwmp 2569 13 injury injury NN cord-015306-us58wwmp 2569 14 ( ( -LRB- cord-015306-us58wwmp 2569 15 AKI AKI NNP cord-015306-us58wwmp 2569 16 ) ) -RRB- cord-015306-us58wwmp 2569 17 during during IN cord-015306-us58wwmp 2569 18 the the DT cord-015306-us58wwmp 2569 19 first first JJ cord-015306-us58wwmp 2569 20 week week NN cord-015306-us58wwmp 2569 21 of of IN cord-015306-us58wwmp 2569 22 life life NN cord-015306-us58wwmp 2569 23 compared compare VBN cord-015306-us58wwmp 2569 24 with with IN cord-015306-us58wwmp 2569 25 those those DT cord-015306-us58wwmp 2569 26 without without IN cord-015306-us58wwmp 2569 27 AKI AKI NNP cord-015306-us58wwmp 2569 28 ( ( -LRB- cord-015306-us58wwmp 2569 29 P p NN cord-015306-us58wwmp 2569 30 = = SYM cord-015306-us58wwmp 2569 31 0.002 0.002 CD cord-015306-us58wwmp 2569 32 ) ) -RRB- cord-015306-us58wwmp 2569 33 and and CC cord-015306-us58wwmp 2569 34 was be VBD cord-015306-us58wwmp 2569 35 also also RB cord-015306-us58wwmp 2569 36 elevated elevate VBN cord-015306-us58wwmp 2569 37 in in IN cord-015306-us58wwmp 2569 38 neonates neonate NNS cord-015306-us58wwmp 2569 39 with with IN cord-015306-us58wwmp 2569 40 brain brain NN cord-015306-us58wwmp 2569 41 injury injury NN cord-015306-us58wwmp 2569 42 , , , cord-015306-us58wwmp 2569 43 as as IN cord-015306-us58wwmp 2569 44 demonstrated demonstrate VBN cord-015306-us58wwmp 2569 45 by by IN cord-015306-us58wwmp 2569 46 ultrasound ultrasound NN cord-015306-us58wwmp 2569 47 or or CC cord-015306-us58wwmp 2569 48 magnetic magnetic JJ cord-015306-us58wwmp 2569 49 resonance resonance NN cord-015306-us58wwmp 2569 50 imaging imaging NN cord-015306-us58wwmp 2569 51 , , , cord-015306-us58wwmp 2569 52 compared compare VBN cord-015306-us58wwmp 2569 53 to to IN cord-015306-us58wwmp 2569 54 neonates neonate NNS cord-015306-us58wwmp 2569 55 without without IN cord-015306-us58wwmp 2569 56 brain brain NN cord-015306-us58wwmp 2569 57 injury injury NN cord-015306-us58wwmp 2570 1 ( ( -LRB- cord-015306-us58wwmp 2570 2 P p NN cord-015306-us58wwmp 2570 3 = = SYM cord-015306-us58wwmp 2570 4 0.008 0.008 CD cord-015306-us58wwmp 2570 5 ) ) -RRB- cord-015306-us58wwmp 2570 6 . . . cord-015306-us58wwmp 2571 1 An an DT cord-015306-us58wwmp 2571 2 increased increase VBN cord-015306-us58wwmp 2571 3 log log NN cord-015306-us58wwmp 2571 4 10 10 CD cord-015306-us58wwmp 2571 5 uEPO uepo JJ cord-015306-us58wwmp 2571 6 level level NN cord-015306-us58wwmp 2571 7 was be VBD cord-015306-us58wwmp 2571 8 associated associate VBN cord-015306-us58wwmp 2571 9 with with IN cord-015306-us58wwmp 2571 10 the the DT cord-015306-us58wwmp 2571 11 occurrence occurrence NN cord-015306-us58wwmp 2571 12 of of IN cord-015306-us58wwmp 2571 13 AKI AKI NNP cord-015306-us58wwmp 2571 14 ( ( -LRB- cord-015306-us58wwmp 2571 15 odds odd NNS cord-015306-us58wwmp 2571 16 ratio ratio NN cord-015306-us58wwmp 2571 17 of of IN cord-015306-us58wwmp 2571 18 2.70 2.70 CD cord-015306-us58wwmp 2571 19 , , , cord-015306-us58wwmp 2571 20 p p NN cord-015306-us58wwmp 2571 21 = = SYM cord-015306-us58wwmp 2571 22 0.007 0.007 CD cord-015306-us58wwmp 2571 23 ) ) -RRB- cord-015306-us58wwmp 2571 24 and and CC cord-015306-us58wwmp 2571 25 brain brain NN cord-015306-us58wwmp 2571 26 injury injury NN cord-015306-us58wwmp 2571 27 ( ( -LRB- cord-015306-us58wwmp 2571 28 odds odd NNS cord-015306-us58wwmp 2571 29 ratio ratio NN cord-015306-us58wwmp 2571 30 of of IN cord-015306-us58wwmp 2571 31 2.33 2.33 CD cord-015306-us58wwmp 2571 32 , , , cord-015306-us58wwmp 2571 33 p p NN cord-015306-us58wwmp 2571 34 = = SYM cord-015306-us58wwmp 2571 35 0.016 0.016 CD cord-015306-us58wwmp 2571 36 ) ) -RRB- cord-015306-us58wwmp 2571 37 . . . cord-015306-us58wwmp 2572 1 Conclusion conclusion NN cord-015306-us58wwmp 2572 2 : : : cord-015306-us58wwmp 2573 1 An an DT cord-015306-us58wwmp 2573 2 increased increased JJ cord-015306-us58wwmp 2573 3 urinary urinary JJ cord-015306-us58wwmp 2573 4 EPO EPO NNP cord-015306-us58wwmp 2573 5 level level NN cord-015306-us58wwmp 2573 6 in in IN cord-015306-us58wwmp 2573 7 the the DT cord-015306-us58wwmp 2573 8 early early JJ cord-015306-us58wwmp 2573 9 postnatal postnatal JJ cord-015306-us58wwmp 2573 10 period period NN cord-015306-us58wwmp 2573 11 is be VBZ cord-015306-us58wwmp 2573 12 significantly significantly RB cord-015306-us58wwmp 2573 13 associated associate VBN cord-015306-us58wwmp 2573 14 with with IN cord-015306-us58wwmp 2573 15 kidney kidney NN cord-015306-us58wwmp 2573 16 and and CC cord-015306-us58wwmp 2573 17 brain brain NN cord-015306-us58wwmp 2573 18 injury injury NN cord-015306-us58wwmp 2573 19 in in IN cord-015306-us58wwmp 2573 20 critically critically RB cord-015306-us58wwmp 2573 21 ill ill JJ cord-015306-us58wwmp 2573 22 neonates neonate NNS cord-015306-us58wwmp 2573 23 . . . cord-015306-us58wwmp 2574 1 Abstract abstract JJ cord-015306-us58wwmp 2574 2 # # NN cord-015306-us58wwmp 2574 3 P p NN cord-015306-us58wwmp 2574 4 - - HYPH cord-015306-us58wwmp 2574 5 SAT311 SAT311 NNP cord-015306-us58wwmp 2574 6 Acute acute JJ cord-015306-us58wwmp 2574 7 kidney kidney NN cord-015306-us58wwmp 2574 8 injury injury NN cord-015306-us58wwmp 2574 9 following follow VBG cord-015306-us58wwmp 2574 10 extracorporeal extracorporeal JJ cord-015306-us58wwmp 2574 11 membrane membrane NN cord-015306-us58wwmp 2574 12 oxygenation oxygenation NN cord-015306-us58wwmp 2574 13 support support NN cord-015306-us58wwmp 2574 14 and and CC cord-015306-us58wwmp 2574 15 concomitant concomitant JJ cord-015306-us58wwmp 2574 16 hemofiltration hemofiltration NN cord-015306-us58wwmp 2574 17 -the -the DT cord-015306-us58wwmp 2574 18 role role NN cord-015306-us58wwmp 2574 19 of of IN cord-015306-us58wwmp 2574 20 diuretics diuretic NNS cord-015306-us58wwmp 2575 1 Objective objective NN cord-015306-us58wwmp 2575 2 : : : cord-015306-us58wwmp 2576 1 Fluid fluid JJ cord-015306-us58wwmp 2576 2 overload overload NN cord-015306-us58wwmp 2576 3 ( ( -LRB- cord-015306-us58wwmp 2576 4 FO FO NNP cord-015306-us58wwmp 2576 5 ) ) -RRB- cord-015306-us58wwmp 2576 6 is be VBZ cord-015306-us58wwmp 2576 7 common common JJ cord-015306-us58wwmp 2576 8 during during IN cord-015306-us58wwmp 2576 9 extracorporeal extracorporeal JJ cord-015306-us58wwmp 2576 10 membrane membrane NN cord-015306-us58wwmp 2576 11 oxygenation oxygenation NN cord-015306-us58wwmp 2576 12 ( ( -LRB- cord-015306-us58wwmp 2576 13 ECMO ECMO NNP cord-015306-us58wwmp 2576 14 ) ) -RRB- cord-015306-us58wwmp 2576 15 and and CC cord-015306-us58wwmp 2576 16 can can MD cord-015306-us58wwmp 2576 17 be be VB cord-015306-us58wwmp 2576 18 managed manage VBN cord-015306-us58wwmp 2576 19 by by IN cord-015306-us58wwmp 2576 20 continuous continuous JJ cord-015306-us58wwmp 2576 21 hemofiltration hemofiltration NN cord-015306-us58wwmp 2576 22 ( ( -LRB- cord-015306-us58wwmp 2576 23 HF HF NNP cord-015306-us58wwmp 2576 24 ) ) -RRB- cord-015306-us58wwmp 2576 25 and/or and/or CC cord-015306-us58wwmp 2576 26 diuretic diuretic JJ cord-015306-us58wwmp 2576 27 therapy therapy NN cord-015306-us58wwmp 2576 28 . . . cord-015306-us58wwmp 2577 1 Although although IN cord-015306-us58wwmp 2577 2 combination combination NN cord-015306-us58wwmp 2577 3 therapy therapy NN cord-015306-us58wwmp 2577 4 of of IN cord-015306-us58wwmp 2577 5 HF HF NNP cord-015306-us58wwmp 2577 6 and and CC cord-015306-us58wwmp 2577 7 diuretics diuretic NNS cord-015306-us58wwmp 2577 8 in in IN cord-015306-us58wwmp 2577 9 particular particular JJ cord-015306-us58wwmp 2577 10 can can MD cord-015306-us58wwmp 2577 11 be be VB cord-015306-us58wwmp 2577 12 most most RBS cord-015306-us58wwmp 2577 13 effectively effectively RB cord-015306-us58wwmp 2577 14 for for IN cord-015306-us58wwmp 2577 15 FO FO NNP cord-015306-us58wwmp 2577 16 removal removal NN cord-015306-us58wwmp 2577 17 during during IN cord-015306-us58wwmp 2577 18 ECMO ECMO NNP cord-015306-us58wwmp 2577 19 , , , cord-015306-us58wwmp 2577 20 it -PRON- PRP cord-015306-us58wwmp 2577 21 may may MD cord-015306-us58wwmp 2577 22 also also RB cord-015306-us58wwmp 2577 23 increase increase VB cord-015306-us58wwmp 2577 24 the the DT cord-015306-us58wwmp 2577 25 risk risk NN cord-015306-us58wwmp 2577 26 for for IN cord-015306-us58wwmp 2577 27 prerenal prerenal JJ cord-015306-us58wwmp 2577 28 acute acute JJ cord-015306-us58wwmp 2577 29 kidney kidney NN cord-015306-us58wwmp 2577 30 injury injury NN cord-015306-us58wwmp 2577 31 ( ( -LRB- cord-015306-us58wwmp 2577 32 AKI AKI NNP cord-015306-us58wwmp 2577 33 ) ) -RRB- cord-015306-us58wwmp 2577 34 post post JJ cord-015306-us58wwmp 2577 35 - - NN cord-015306-us58wwmp 2577 36 ECMO ECMO NNP cord-015306-us58wwmp 2577 37 . . . cord-015306-us58wwmp 2578 1 Our -PRON- PRP$ cord-015306-us58wwmp 2578 2 objective objective NN cord-015306-us58wwmp 2578 3 was be VBD cord-015306-us58wwmp 2578 4 to to TO cord-015306-us58wwmp 2578 5 describe describe VB cord-015306-us58wwmp 2578 6 the the DT cord-015306-us58wwmp 2578 7 incidence incidence NN cord-015306-us58wwmp 2578 8 of of IN cord-015306-us58wwmp 2578 9 AKI AKI NNP cord-015306-us58wwmp 2578 10 post post NN cord-015306-us58wwmp 2578 11 - - NN cord-015306-us58wwmp 2578 12 ECMO ecmo NN cord-015306-us58wwmp 2578 13 in in IN cord-015306-us58wwmp 2578 14 patients patient NNS cord-015306-us58wwmp 2578 15 treated treat VBN cord-015306-us58wwmp 2578 16 with with IN cord-015306-us58wwmp 2578 17 ECMO ECMO NNP cord-015306-us58wwmp 2578 18 and and CC cord-015306-us58wwmp 2578 19 HF HF NNP cord-015306-us58wwmp 2578 20 who who WP cord-015306-us58wwmp 2578 21 received receive VBD cord-015306-us58wwmp 2578 22 concurrent concurrent JJ cord-015306-us58wwmp 2578 23 diuretics diuretic NNS cord-015306-us58wwmp 2578 24 . . . cord-015306-us58wwmp 2579 1 Methods method NNS cord-015306-us58wwmp 2579 2 : : : cord-015306-us58wwmp 2579 3 In in IN cord-015306-us58wwmp 2579 4 this this DT cord-015306-us58wwmp 2579 5 cohort cohort NN cord-015306-us58wwmp 2579 6 study study NN cord-015306-us58wwmp 2579 7 all all DT cord-015306-us58wwmp 2579 8 neonates neonate NNS cord-015306-us58wwmp 2579 9 ( ( -LRB- cord-015306-us58wwmp 2579 10 ≤28 ≤28 NNS cord-015306-us58wwmp 2579 11 days day NNS cord-015306-us58wwmp 2579 12 after after IN cord-015306-us58wwmp 2579 13 birth birth NN cord-015306-us58wwmp 2579 14 ) ) -RRB- cord-015306-us58wwmp 2579 15 treated treat VBN cord-015306-us58wwmp 2579 16 with with IN cord-015306-us58wwmp 2579 17 ECMO ecmo NN cord-015306-us58wwmp 2579 18 and and CC cord-015306-us58wwmp 2579 19 concomitant concomitant JJ cord-015306-us58wwmp 2579 20 HF HF NNP cord-015306-us58wwmp 2579 21 between between IN cord-015306-us58wwmp 2579 22 2007 2007 CD cord-015306-us58wwmp 2579 23 and and CC cord-015306-us58wwmp 2579 24 2011 2011 CD cord-015306-us58wwmp 2579 25 were be VBD cord-015306-us58wwmp 2579 26 included include VBN cord-015306-us58wwmp 2579 27 . . . cord-015306-us58wwmp 2580 1 Patients patient NNS cord-015306-us58wwmp 2580 2 were be VBD cord-015306-us58wwmp 2580 3 divided divide VBN cord-015306-us58wwmp 2580 4 into into IN cord-015306-us58wwmp 2580 5 two two CD cord-015306-us58wwmp 2580 6 groups group NNS cord-015306-us58wwmp 2580 7 based base VBN cord-015306-us58wwmp 2580 8 on on IN cord-015306-us58wwmp 2580 9 diuretic diuretic JJ cord-015306-us58wwmp 2580 10 regimen regimen NN cord-015306-us58wwmp 2580 11 : : : cord-015306-us58wwmp 2580 12 Group-1 group-1 UH cord-015306-us58wwmp 2580 13 , , , cord-015306-us58wwmp 2580 14 patients patient NNS cord-015306-us58wwmp 2580 15 who who WP cord-015306-us58wwmp 2580 16 received receive VBD cord-015306-us58wwmp 2580 17 no no DT cord-015306-us58wwmp 2580 18 or or CC cord-015306-us58wwmp 2580 19 one one CD cord-015306-us58wwmp 2580 20 single single JJ cord-015306-us58wwmp 2580 21 diuretic diuretic JJ cord-015306-us58wwmp 2580 22 dose dose NN cord-015306-us58wwmp 2580 23 during during IN cord-015306-us58wwmp 2580 24 ECMO ECMO NNP cord-015306-us58wwmp 2580 25 and and CC cord-015306-us58wwmp 2580 26 Group-2 Group-2 NNP cord-015306-us58wwmp 2580 27 , , , cord-015306-us58wwmp 2580 28 patients patient NNS cord-015306-us58wwmp 2580 29 who who WP cord-015306-us58wwmp 2580 30 repeatedly repeatedly RB cord-015306-us58wwmp 2580 31 received receive VBD cord-015306-us58wwmp 2580 32 diuretics diuretic NNS cord-015306-us58wwmp 2580 33 . . . cord-015306-us58wwmp 2581 1 Both both DT cord-015306-us58wwmp 2581 2 groups group NNS cord-015306-us58wwmp 2581 3 were be VBD cord-015306-us58wwmp 2581 4 compared compare VBN cord-015306-us58wwmp 2581 5 using use VBG cord-015306-us58wwmp 2581 6 Mann Mann NNP cord-015306-us58wwmp 2581 7 - - HYPH cord-015306-us58wwmp 2581 8 Whitney Whitney NNP cord-015306-us58wwmp 2581 9 U U NNP cord-015306-us58wwmp 2581 10 test test VBP cord-015306-us58wwmp 2581 11 for for IN cord-015306-us58wwmp 2581 12 nonparametric nonparametric JJ cord-015306-us58wwmp 2581 13 data datum NNS cord-015306-us58wwmp 2581 14 and and CC cord-015306-us58wwmp 2581 15 Chisquare Chisquare NNP cord-015306-us58wwmp 2581 16 test test NN cord-015306-us58wwmp 2581 17 for for IN cord-015306-us58wwmp 2581 18 categorical categorical JJ cord-015306-us58wwmp 2581 19 data datum NNS cord-015306-us58wwmp 2581 20 . . . cord-015306-us58wwmp 2582 1 AKI AKI NNP cord-015306-us58wwmp 2582 2 was be VBD cord-015306-us58wwmp 2582 3 defined define VBN cord-015306-us58wwmp 2582 4 as as IN cord-015306-us58wwmp 2582 5 the the DT cord-015306-us58wwmp 2582 6 highest high JJS cord-015306-us58wwmp 2582 7 serum serum NN cord-015306-us58wwmp 2582 8 creatinine creatinine NN cord-015306-us58wwmp 2582 9 ( ( -LRB- cord-015306-us58wwmp 2582 10 SCr)-based SCr)-based NNP cord-015306-us58wwmp 2582 11 RIFLE rifle NN cord-015306-us58wwmp 2582 12 class class NN cord-015306-us58wwmp 2582 13 reached reach VBD cord-015306-us58wwmp 2582 14 on on IN cord-015306-us58wwmp 2582 15 post post JJ cord-015306-us58wwmp 2582 16 - - JJ cord-015306-us58wwmp 2582 17 ECMO ecmo JJ cord-015306-us58wwmp 2582 18 day day NN cord-015306-us58wwmp 2582 19 1 1 CD cord-015306-us58wwmp 2582 20 up up RP cord-015306-us58wwmp 2582 21 to to IN cord-015306-us58wwmp 2582 22 post post VB cord-015306-us58wwmp 2582 23 - - JJ cord-015306-us58wwmp 2582 24 ECMO ecmo JJ cord-015306-us58wwmp 2582 25 day day NN cord-015306-us58wwmp 2582 26 4 4 CD cord-015306-us58wwmp 2583 1 ( ( -LRB- cord-015306-us58wwmp 2583 2 Risk risk NN cord-015306-us58wwmp 2583 3 , , , cord-015306-us58wwmp 2583 4 Injury injury NN cord-015306-us58wwmp 2583 5 , , , cord-015306-us58wwmp 2583 6 or or CC cord-015306-us58wwmp 2583 7 Failure failure NN cord-015306-us58wwmp 2583 8 being be VBG cord-015306-us58wwmp 2583 9 150 150 CD cord-015306-us58wwmp 2583 10 % % NN cord-015306-us58wwmp 2583 11 , , , cord-015306-us58wwmp 2583 12 200 200 CD cord-015306-us58wwmp 2583 13 % % NN cord-015306-us58wwmp 2583 14 or or CC cord-015306-us58wwmp 2583 15 300 300 CD cord-015306-us58wwmp 2583 16 % % NN cord-015306-us58wwmp 2583 17 of of IN cord-015306-us58wwmp 2583 18 median median JJ cord-015306-us58wwmp 2583 19 SCr scr NN cord-015306-us58wwmp 2583 20 reference reference NN cord-015306-us58wwmp 2583 21 values value NNS cord-015306-us58wwmp 2583 22 for for IN cord-015306-us58wwmp 2583 23 age age NN cord-015306-us58wwmp 2583 24 ) ) -RRB- cord-015306-us58wwmp 2583 25 . . . cord-015306-us58wwmp 2584 1 Results result NNS cord-015306-us58wwmp 2584 2 : : : cord-015306-us58wwmp 2585 1 56 56 CD cord-015306-us58wwmp 2585 2 neonates neonate NNS cord-015306-us58wwmp 2585 3 received receive VBD cord-015306-us58wwmp 2585 4 ECMO ECMO NNP cord-015306-us58wwmp 2585 5 support support NN cord-015306-us58wwmp 2585 6 with with IN cord-015306-us58wwmp 2585 7 HF HF NNP cord-015306-us58wwmp 2585 8 , , , cord-015306-us58wwmp 2585 9 6 6 CD cord-015306-us58wwmp 2585 10 died die VBD cord-015306-us58wwmp 2585 11 immediately immediately RB cord-015306-us58wwmp 2585 12 following follow VBG cord-015306-us58wwmp 2585 13 decannulation decannulation NN cord-015306-us58wwmp 2585 14 and and CC cord-015306-us58wwmp 2585 15 6 6 CD cord-015306-us58wwmp 2585 16 others other NNS cord-015306-us58wwmp 2585 17 were be VBD cord-015306-us58wwmp 2585 18 lost lose VBN cord-015306-us58wwmp 2585 19 to to TO cord-015306-us58wwmp 2585 20 followup followup VB cord-015306-us58wwmp 2585 21 since since IN cord-015306-us58wwmp 2585 22 they -PRON- PRP cord-015306-us58wwmp 2585 23 were be VBD cord-015306-us58wwmp 2585 24 transferred transfer VBN cord-015306-us58wwmp 2585 25 back back RB cord-015306-us58wwmp 2585 26 to to IN cord-015306-us58wwmp 2585 27 their -PRON- PRP$ cord-015306-us58wwmp 2585 28 referring refer VBG cord-015306-us58wwmp 2585 29 hospitals hospital NNS cord-015306-us58wwmp 2585 30 within within IN cord-015306-us58wwmp 2585 31 3 3 CD cord-015306-us58wwmp 2585 32 days day NNS cord-015306-us58wwmp 2585 33 post post NN cord-015306-us58wwmp 2585 34 - - NN cord-015306-us58wwmp 2585 35 ECMO ECMO NNP cord-015306-us58wwmp 2585 36 . . . cord-015306-us58wwmp 2586 1 Of of IN cord-015306-us58wwmp 2586 2 the the DT cord-015306-us58wwmp 2586 3 18 18 CD cord-015306-us58wwmp 2586 4 patients patient NNS cord-015306-us58wwmp 2586 5 in in IN cord-015306-us58wwmp 2586 6 Group-1 Group-1 NNP cord-015306-us58wwmp 2586 7 , , , cord-015306-us58wwmp 2586 8 3 3 CD cord-015306-us58wwmp 2586 9 ( ( -LRB- cord-015306-us58wwmp 2586 10 17 17 CD cord-015306-us58wwmp 2586 11 % % NN cord-015306-us58wwmp 2586 12 ) ) -RRB- cord-015306-us58wwmp 2586 13 qualified qualified JJ cord-015306-us58wwmp 2586 14 as as IN cord-015306-us58wwmp 2586 15 Risk risk NN cord-015306-us58wwmp 2586 16 and and CC cord-015306-us58wwmp 2586 17 1 1 CD cord-015306-us58wwmp 2586 18 ( ( -LRB- cord-015306-us58wwmp 2586 19 6 6 CD cord-015306-us58wwmp 2586 20 % % NN cord-015306-us58wwmp 2586 21 ) ) -RRB- cord-015306-us58wwmp 2586 22 as as IN cord-015306-us58wwmp 2586 23 Injury injury NN cord-015306-us58wwmp 2586 24 . . . cord-015306-us58wwmp 2587 1 Of of IN cord-015306-us58wwmp 2587 2 the the DT cord-015306-us58wwmp 2587 3 26 26 CD cord-015306-us58wwmp 2587 4 patients patient NNS cord-015306-us58wwmp 2587 5 in in IN cord-015306-us58wwmp 2587 6 Group-2 Group-2 NNP cord-015306-us58wwmp 2587 7 , , , cord-015306-us58wwmp 2587 8 3 3 CD cord-015306-us58wwmp 2587 9 ( ( -LRB- cord-015306-us58wwmp 2587 10 12 12 CD cord-015306-us58wwmp 2587 11 % % NN cord-015306-us58wwmp 2587 12 ) ) -RRB- cord-015306-us58wwmp 2587 13 qualified qualified JJ cord-015306-us58wwmp 2587 14 as as IN cord-015306-us58wwmp 2587 15 Risk Risk NNP cord-015306-us58wwmp 2587 16 , , , cord-015306-us58wwmp 2587 17 4 4 CD cord-015306-us58wwmp 2587 18 ( ( -LRB- cord-015306-us58wwmp 2587 19 15 15 CD cord-015306-us58wwmp 2587 20 % % NN cord-015306-us58wwmp 2587 21 ) ) -RRB- cord-015306-us58wwmp 2587 22 as as IN cord-015306-us58wwmp 2587 23 Injury injury NN cord-015306-us58wwmp 2587 24 and and CC cord-015306-us58wwmp 2587 25 9 9 CD cord-015306-us58wwmp 2587 26 ( ( -LRB- cord-015306-us58wwmp 2587 27 35 35 CD cord-015306-us58wwmp 2587 28 % % NN cord-015306-us58wwmp 2587 29 ) ) -RRB- cord-015306-us58wwmp 2587 30 as as IN cord-015306-us58wwmp 2587 31 Failure failure NN cord-015306-us58wwmp 2587 32 ( ( -LRB- cord-015306-us58wwmp 2587 33 Group-1 Group-1 NNP cord-015306-us58wwmp 2587 34 vs. vs. FW cord-015306-us58wwmp 2587 35 Group-2 Group-2 NNP cord-015306-us58wwmp 2587 36 , , , cord-015306-us58wwmp 2587 37 p=0.039 p=0.039 NNP cord-015306-us58wwmp 2587 38 ) ) -RRB- cord-015306-us58wwmp 2587 39 . . . cord-015306-us58wwmp 2588 1 Patients patient NNS cord-015306-us58wwmp 2588 2 in in IN cord-015306-us58wwmp 2588 3 Group-2 Group-2 NNP cord-015306-us58wwmp 2588 4 had have VBD cord-015306-us58wwmp 2588 5 an an DT cord-015306-us58wwmp 2588 6 increased increase VBN cord-015306-us58wwmp 2588 7 ECMO ecmo NN cord-015306-us58wwmp 2588 8 duration duration NN cord-015306-us58wwmp 2588 9 ( ( -LRB- cord-015306-us58wwmp 2588 10 p=0.001 p=0.001 NNS cord-015306-us58wwmp 2588 11 ) ) -RRB- cord-015306-us58wwmp 2588 12 and and CC cord-015306-us58wwmp 2588 13 number number NN cord-015306-us58wwmp 2588 14 of of IN cord-015306-us58wwmp 2588 15 ventilator ventilator NN cord-015306-us58wwmp 2588 16 days day NNS cord-015306-us58wwmp 2588 17 ( ( -LRB- cord-015306-us58wwmp 2588 18 p=0.002 p=0.002 NNP cord-015306-us58wwmp 2588 19 ) ) -RRB- cord-015306-us58wwmp 2588 20 . . . cord-015306-us58wwmp 2589 1 No no DT cord-015306-us58wwmp 2589 2 differences difference NNS cord-015306-us58wwmp 2589 3 were be VBD cord-015306-us58wwmp 2589 4 observed observe VBN cord-015306-us58wwmp 2589 5 in in IN cord-015306-us58wwmp 2589 6 baseline baseline JJ cord-015306-us58wwmp 2589 7 characteristics characteristic NNS cord-015306-us58wwmp 2589 8 ( ( -LRB- cord-015306-us58wwmp 2589 9 e.g. e.g. JJ cord-015306-us58wwmp 2589 10 age age NN cord-015306-us58wwmp 2589 11 at at IN cord-015306-us58wwmp 2589 12 the the DT cord-015306-us58wwmp 2589 13 start start NN cord-015306-us58wwmp 2589 14 of of IN cord-015306-us58wwmp 2589 15 ECMO ECMO NNP cord-015306-us58wwmp 2589 16 , , , cord-015306-us58wwmp 2589 17 underlying underlie VBG cord-015306-us58wwmp 2589 18 diagnosis diagnosis NN cord-015306-us58wwmp 2589 19 , , , cord-015306-us58wwmp 2589 20 severity severity NN cord-015306-us58wwmp 2589 21 of of IN cord-015306-us58wwmp 2589 22 illness illness NN cord-015306-us58wwmp 2589 23 scoring score VBG cord-015306-us58wwmp 2589 24 using use VBG cord-015306-us58wwmp 2589 25 the the DT cord-015306-us58wwmp 2589 26 PIM PIM NNP cord-015306-us58wwmp 2589 27 and and CC cord-015306-us58wwmp 2589 28 PRISM PRISM NNP cord-015306-us58wwmp 2589 29 risk risk NN cord-015306-us58wwmp 2589 30 adjustment adjustment NN cord-015306-us58wwmp 2589 31 systems system NNS cord-015306-us58wwmp 2589 32 ) ) -RRB- cord-015306-us58wwmp 2589 33 , , , cord-015306-us58wwmp 2589 34 HF HF NNP cord-015306-us58wwmp 2589 35 flow flow NN cord-015306-us58wwmp 2589 36 rate rate NN cord-015306-us58wwmp 2589 37 , , , cord-015306-us58wwmp 2589 38 and and CC cord-015306-us58wwmp 2589 39 fluid fluid JJ cord-015306-us58wwmp 2589 40 balance balance NN cord-015306-us58wwmp 2589 41 between between IN cord-015306-us58wwmp 2589 42 both both DT cord-015306-us58wwmp 2589 43 study study NN cord-015306-us58wwmp 2589 44 groups group NNS cord-015306-us58wwmp 2589 45 . . . cord-015306-us58wwmp 2590 1 Conclusion conclusion NN cord-015306-us58wwmp 2590 2 : : : cord-015306-us58wwmp 2591 1 The the DT cord-015306-us58wwmp 2591 2 incidence incidence NN cord-015306-us58wwmp 2591 3 and and CC cord-015306-us58wwmp 2591 4 severity severity NN cord-015306-us58wwmp 2591 5 of of IN cord-015306-us58wwmp 2591 6 AKI AKI NNP cord-015306-us58wwmp 2591 7 immediately immediately RB cord-015306-us58wwmp 2591 8 post post VBP cord-015306-us58wwmp 2591 9 - - NN cord-015306-us58wwmp 2591 10 ECMO ECMO NNP cord-015306-us58wwmp 2591 11 was be VBD cord-015306-us58wwmp 2591 12 significantly significantly RB cord-015306-us58wwmp 2591 13 higher high JJR cord-015306-us58wwmp 2591 14 in in IN cord-015306-us58wwmp 2591 15 patients patient NNS cord-015306-us58wwmp 2591 16 who who WP cord-015306-us58wwmp 2591 17 repeatedly repeatedly RB cord-015306-us58wwmp 2591 18 received receive VBD cord-015306-us58wwmp 2591 19 diuretics diuretic NNS cord-015306-us58wwmp 2591 20 in in IN cord-015306-us58wwmp 2591 21 addition addition NN cord-015306-us58wwmp 2591 22 to to IN cord-015306-us58wwmp 2591 23 HF HF NNP cord-015306-us58wwmp 2591 24 during during IN cord-015306-us58wwmp 2591 25 ECMO ECMO NNP cord-015306-us58wwmp 2591 26 . . . cord-015306-us58wwmp 2592 1 Valentina Valentina NNP cord-015306-us58wwmp 2592 2 Sitnikova Sitnikova NNP cord-015306-us58wwmp 2592 3 , , , cord-015306-us58wwmp 2592 4 Yuliya Yuliya NNP cord-015306-us58wwmp 2592 5 Pashkova Pashkova NNP cord-015306-us58wwmp 2592 6 , , , cord-015306-us58wwmp 2592 7 Tatiana Tatiana NNP cord-015306-us58wwmp 2592 8 Zvyagina Zvyagina NNP cord-015306-us58wwmp 2592 9 , , , cord-015306-us58wwmp 2592 10 Elena Elena NNP cord-015306-us58wwmp 2592 11 Kulakova Kulakova NNP cord-015306-us58wwmp 2592 12 , , , cord-015306-us58wwmp 2592 13 Alexandra Alexandra NNP cord-015306-us58wwmp 2592 14 Nastausheva Nastausheva NNP cord-015306-us58wwmp 2592 15 Voronezh Voronezh NNP cord-015306-us58wwmp 2592 16 state state NN cord-015306-us58wwmp 2592 17 medical medical JJ cord-015306-us58wwmp 2592 18 academy academy NN cord-015306-us58wwmp 2592 19 , , , cord-015306-us58wwmp 2592 20 Voronezh Voronezh NNP cord-015306-us58wwmp 2592 21 , , , cord-015306-us58wwmp 2593 1 Russia Russia NNP cord-015306-us58wwmp 2593 2 Objective Objective NNP cord-015306-us58wwmp 2593 3 : : : cord-015306-us58wwmp 2594 1 It -PRON- PRP cord-015306-us58wwmp 2594 2 is be VBZ cord-015306-us58wwmp 2594 3 actually actually RB cord-015306-us58wwmp 2594 4 to to TO cord-015306-us58wwmp 2594 5 find find VB cord-015306-us58wwmp 2594 6 the the DT cord-015306-us58wwmp 2594 7 new new JJ cord-015306-us58wwmp 2594 8 markers marker NNS cord-015306-us58wwmp 2594 9 of of IN cord-015306-us58wwmp 2594 10 kidney kidney NN cord-015306-us58wwmp 2594 11 damage damage NN cord-015306-us58wwmp 2594 12 and and CC cord-015306-us58wwmp 2594 13 spread spread VBD cord-015306-us58wwmp 2594 14 them -PRON- PRP cord-015306-us58wwmp 2594 15 in in IN cord-015306-us58wwmp 2594 16 practice practice NN cord-015306-us58wwmp 2594 17 . . . cord-015306-us58wwmp 2595 1 Cystatine Cystatine NNP cord-015306-us58wwmp 2595 2 C C NNP cord-015306-us58wwmp 2595 3 ( ( -LRB- cord-015306-us58wwmp 2595 4 Cys Cys NNP cord-015306-us58wwmp 2595 5 ) ) -RRB- cord-015306-us58wwmp 2595 6 is be VBZ cord-015306-us58wwmp 2595 7 one one CD cord-015306-us58wwmp 2595 8 of of IN cord-015306-us58wwmp 2595 9 these these DT cord-015306-us58wwmp 2595 10 , , , cord-015306-us58wwmp 2595 11 but but CC cord-015306-us58wwmp 2595 12 there there EX cord-015306-us58wwmp 2595 13 are be VBP cord-015306-us58wwmp 2595 14 only only RB cord-015306-us58wwmp 2595 15 few few JJ cord-015306-us58wwmp 2595 16 data datum NNS cord-015306-us58wwmp 2595 17 about about IN cord-015306-us58wwmp 2595 18 it -PRON- PRP cord-015306-us58wwmp 2595 19 in in IN cord-015306-us58wwmp 2595 20 children child NNS cord-015306-us58wwmp 2595 21 with with IN cord-015306-us58wwmp 2595 22 urinary urinary JJ cord-015306-us58wwmp 2595 23 tract tract NN cord-015306-us58wwmp 2595 24 infection infection NN cord-015306-us58wwmp 2595 25 ( ( -LRB- cord-015306-us58wwmp 2595 26 UTI UTI NNP cord-015306-us58wwmp 2595 27 ) ) -RRB- cord-015306-us58wwmp 2595 28 according accord VBG cord-015306-us58wwmp 2595 29 to to IN cord-015306-us58wwmp 2595 30 the the DT cord-015306-us58wwmp 2595 31 age age NN cord-015306-us58wwmp 2595 32 . . . cord-015306-us58wwmp 2596 1 The the DT cord-015306-us58wwmp 2596 2 aim aim NN cord-015306-us58wwmp 2596 3 of of IN cord-015306-us58wwmp 2596 4 our -PRON- PRP$ cord-015306-us58wwmp 2596 5 study study NN cord-015306-us58wwmp 2596 6 was be VBD cord-015306-us58wwmp 2596 7 to to TO cord-015306-us58wwmp 2596 8 evaluate evaluate VB cord-015306-us58wwmp 2596 9 serum serum NN cord-015306-us58wwmp 2596 10 concentration concentration NN cord-015306-us58wwmp 2596 11 of of IN cord-015306-us58wwmp 2596 12 Cys Cys NNP cord-015306-us58wwmp 2596 13 in in IN cord-015306-us58wwmp 2596 14 children child NNS cord-015306-us58wwmp 2596 15 with with IN cord-015306-us58wwmp 2596 16 UTI UTI NNP cord-015306-us58wwmp 2596 17 of of IN cord-015306-us58wwmp 2596 18 different different JJ cord-015306-us58wwmp 2596 19 age age NN cord-015306-us58wwmp 2596 20 . . . cord-015306-us58wwmp 2597 1 We -PRON- PRP cord-015306-us58wwmp 2597 2 investigated investigate VBD cord-015306-us58wwmp 2597 3 83 83 CD cord-015306-us58wwmp 2597 4 patients patient NNS cord-015306-us58wwmp 2597 5 ( ( -LRB- cord-015306-us58wwmp 2597 6 47 47 CD cord-015306-us58wwmp 2597 7 girls girl NNS cord-015306-us58wwmp 2597 8 and and CC cord-015306-us58wwmp 2597 9 36 36 CD cord-015306-us58wwmp 2597 10 boys boy NNS cord-015306-us58wwmp 2597 11 ) ) -RRB- cord-015306-us58wwmp 2597 12 with with IN cord-015306-us58wwmp 2597 13 UTI UTI NNP cord-015306-us58wwmp 2597 14 from from IN cord-015306-us58wwmp 2597 15 1 1 CD cord-015306-us58wwmp 2597 16 month month NN cord-015306-us58wwmp 2597 17 to to IN cord-015306-us58wwmp 2597 18 17 17 CD cord-015306-us58wwmp 2597 19 years year NNS cord-015306-us58wwmp 2597 20 among among IN cord-015306-us58wwmp 2597 21 them -PRON- PRP cord-015306-us58wwmp 2597 22 32 32 CD cord-015306-us58wwmp 2597 23 children child NNS cord-015306-us58wwmp 2597 24 were be VBD cord-015306-us58wwmp 2597 25 under under IN cord-015306-us58wwmp 2597 26 1 1 CD cord-015306-us58wwmp 2597 27 years year NNS cord-015306-us58wwmp 2597 28 old old JJ cord-015306-us58wwmp 2597 29 . . . cord-015306-us58wwmp 2598 1 Methods method NNS cord-015306-us58wwmp 2598 2 : : : cord-015306-us58wwmp 2599 1 Concentration concentration NN cord-015306-us58wwmp 2599 2 of of IN cord-015306-us58wwmp 2599 3 Cys Cys NNP cord-015306-us58wwmp 2599 4 were be VBD cord-015306-us58wwmp 2599 5 measured measure VBN cord-015306-us58wwmp 2599 6 by by IN cord-015306-us58wwmp 2599 7 immunoenzime immunoenzime NN cord-015306-us58wwmp 2599 8 method method NN cord-015306-us58wwmp 2599 9 ( ( -LRB- cord-015306-us58wwmp 2599 10 ELISA ELISA NNP cord-015306-us58wwmp 2599 11 ) ) -RRB- cord-015306-us58wwmp 2599 12 with with IN cord-015306-us58wwmp 2599 13 test test NN cord-015306-us58wwmp 2599 14 - - HYPH cord-015306-us58wwmp 2599 15 system system NN cord-015306-us58wwmp 2599 16 BioVendor BioVendor NNP cord-015306-us58wwmp 2599 17 ( ( -LRB- cord-015306-us58wwmp 2599 18 Check check VB cord-015306-us58wwmp 2599 19 Republic Republic NNP cord-015306-us58wwmp 2599 20 ) ) -RRB- cord-015306-us58wwmp 2599 21 . . . cord-015306-us58wwmp 2600 1 Results result NNS cord-015306-us58wwmp 2600 2 : : : cord-015306-us58wwmp 2601 1 The the DT cord-015306-us58wwmp 2601 2 mean mean JJ cord-015306-us58wwmp 2601 3 Cys Cys NNP cord-015306-us58wwmp 2601 4 concentration concentration NN cord-015306-us58wwmp 2601 5 in in IN cord-015306-us58wwmp 2601 6 children child NNS cord-015306-us58wwmp 2601 7 with with IN cord-015306-us58wwmp 2601 8 UTI UTI NNP cord-015306-us58wwmp 2601 9 under under IN cord-015306-us58wwmp 2601 10 1 1 CD cord-015306-us58wwmp 2601 11 year year NN cord-015306-us58wwmp 2601 12 was be VBD cord-015306-us58wwmp 2601 13 1.43± 1.43± JJ cord-015306-us58wwmp 2601 14 0.37 0.37 CD cord-015306-us58wwmp 2601 15 mg mg NNP cord-015306-us58wwmp 2601 16 / / SYM cord-015306-us58wwmp 2601 17 l l NNP cord-015306-us58wwmp 2601 18 , , , cord-015306-us58wwmp 2601 19 in in IN cord-015306-us58wwmp 2601 20 older old JJR cord-015306-us58wwmp 2601 21 children child NNS cord-015306-us58wwmp 2601 22 it -PRON- PRP cord-015306-us58wwmp 2601 23 was be VBD cord-015306-us58wwmp 2601 24 lower low JJR cord-015306-us58wwmp 2601 25 : : : cord-015306-us58wwmp 2601 26 1.23 1.23 CD cord-015306-us58wwmp 2601 27 ± ± CD cord-015306-us58wwmp 2601 28 0.36 0.36 CD cord-015306-us58wwmp 2602 1 mg mg NNP cord-015306-us58wwmp 2602 2 / / SYM cord-015306-us58wwmp 2602 3 l l NNP cord-015306-us58wwmp 2602 4 , , , cord-015306-us58wwmp 2602 5 p= p= NNP cord-015306-us58wwmp 2602 6 0.025 0.025 CD cord-015306-us58wwmp 2603 1 ( ( -LRB- cord-015306-us58wwmp 2603 2 Mann Mann NNP cord-015306-us58wwmp 2603 3 - - HYPH cord-015306-us58wwmp 2603 4 Whitney Whitney NNP cord-015306-us58wwmp 2603 5 ) ) -RRB- cord-015306-us58wwmp 2603 6 . . . cord-015306-us58wwmp 2604 1 In in IN cord-015306-us58wwmp 2604 2 16 16 CD cord-015306-us58wwmp 2604 3 girls girl NNS cord-015306-us58wwmp 2604 4 before before IN cord-015306-us58wwmp 2604 5 1 1 CD cord-015306-us58wwmp 2604 6 year year NN cord-015306-us58wwmp 2604 7 Cys Cys NNP cord-015306-us58wwmp 2604 8 concentration concentration NN cord-015306-us58wwmp 2604 9 was be VBD cord-015306-us58wwmp 2604 10 1.47± 1.47± CD cord-015306-us58wwmp 2604 11 0.32 0.32 CD cord-015306-us58wwmp 2604 12 mg mg NNP cord-015306-us58wwmp 2604 13 / / SYM cord-015306-us58wwmp 2604 14 l l NNP cord-015306-us58wwmp 2604 15 and and CC cord-015306-us58wwmp 2604 16 in in IN cord-015306-us58wwmp 2604 17 16 16 CD cord-015306-us58wwmp 2604 18 boys boy NNS cord-015306-us58wwmp 2604 19 of of IN cord-015306-us58wwmp 2604 20 the the DT cord-015306-us58wwmp 2604 21 same same JJ cord-015306-us58wwmp 2604 22 age age NN cord-015306-us58wwmp 2604 23 it -PRON- PRP cord-015306-us58wwmp 2604 24 was be VBD cord-015306-us58wwmp 2604 25 1.40±0.43 1.40±0.43 CD cord-015306-us58wwmp 2605 1 mg mg NNP cord-015306-us58wwmp 2605 2 / / SYM cord-015306-us58wwmp 2605 3 l l NNP cord-015306-us58wwmp 2605 4 , , , cord-015306-us58wwmp 2605 5 p>0.05 p>0.05 NNP cord-015306-us58wwmp 2605 6 . . . cord-015306-us58wwmp 2606 1 In in IN cord-015306-us58wwmp 2606 2 31 31 CD cord-015306-us58wwmp 2606 3 girls girl NNS cord-015306-us58wwmp 2606 4 over over IN cord-015306-us58wwmp 2606 5 1 1 CD cord-015306-us58wwmp 2606 6 year year NN cord-015306-us58wwmp 2606 7 Cys Cys NNP cord-015306-us58wwmp 2606 8 concentration concentration NN cord-015306-us58wwmp 2606 9 in in IN cord-015306-us58wwmp 2606 10 serum serum NN cord-015306-us58wwmp 2606 11 was be VBD cord-015306-us58wwmp 2606 12 1.31± 1.31± CD cord-015306-us58wwmp 2607 1 0.41 0.41 CD cord-015306-us58wwmp 2607 2 mg mg NNP cord-015306-us58wwmp 2607 3 / / SYM cord-015306-us58wwmp 2607 4 l l NN cord-015306-us58wwmp 2608 1 , , , cord-015306-us58wwmp 2608 2 in in IN cord-015306-us58wwmp 2608 3 20 20 CD cord-015306-us58wwmp 2608 4 boys boy NNS cord-015306-us58wwmp 2608 5 -1.3± -1.3± RB cord-015306-us58wwmp 2608 6 0.33 0.33 CD cord-015306-us58wwmp 2608 7 mg mg NNP cord-015306-us58wwmp 2608 8 / / SYM cord-015306-us58wwmp 2608 9 l l NNP cord-015306-us58wwmp 2608 10 , , , cord-015306-us58wwmp 2608 11 p>0.05 p>0.05 NNP cord-015306-us58wwmp 2608 12 . . . cord-015306-us58wwmp 2609 1 The the DT cord-015306-us58wwmp 2609 2 results result NNS cord-015306-us58wwmp 2609 3 of of IN cord-015306-us58wwmp 2609 4 our -PRON- PRP$ cord-015306-us58wwmp 2609 5 study study NN cord-015306-us58wwmp 2609 6 showed show VBD cord-015306-us58wwmp 2609 7 that that IN cord-015306-us58wwmp 2609 8 among among IN cord-015306-us58wwmp 2609 9 children child NNS cord-015306-us58wwmp 2609 10 with with IN cord-015306-us58wwmp 2609 11 UTI UTI NNP cord-015306-us58wwmp 2609 12 serum serum NN cord-015306-us58wwmp 2609 13 concentration concentration NN cord-015306-us58wwmp 2609 14 of of IN cord-015306-us58wwmp 2609 15 Cys Cys NNP cord-015306-us58wwmp 2609 16 was be VBD cord-015306-us58wwmp 2609 17 higher high JJR cord-015306-us58wwmp 2609 18 in in IN cord-015306-us58wwmp 2609 19 children child NNS cord-015306-us58wwmp 2609 20 of of IN cord-015306-us58wwmp 2609 21 the the DT cord-015306-us58wwmp 2609 22 first first JJ cord-015306-us58wwmp 2609 23 year year NN cord-015306-us58wwmp 2609 24 of of IN cord-015306-us58wwmp 2609 25 life life NN cord-015306-us58wwmp 2609 26 and and CC cord-015306-us58wwmp 2609 27 did do VBD cord-015306-us58wwmp 2609 28 not not RB cord-015306-us58wwmp 2609 29 depend depend VB cord-015306-us58wwmp 2609 30 on on IN cord-015306-us58wwmp 2609 31 sex sex NN cord-015306-us58wwmp 2609 32 . . . cord-015306-us58wwmp 2610 1 Probably probably RB cord-015306-us58wwmp 2610 2 , , , cord-015306-us58wwmp 2610 3 higher high JJR cord-015306-us58wwmp 2610 4 level level NN cord-015306-us58wwmp 2610 5 of of IN cord-015306-us58wwmp 2610 6 Cys Cys NNP cord-015306-us58wwmp 2610 7 in in IN cord-015306-us58wwmp 2610 8 infants infant NNS cord-015306-us58wwmp 2610 9 connects connect VBZ cord-015306-us58wwmp 2610 10 with with IN cord-015306-us58wwmp 2610 11 low low JJ cord-015306-us58wwmp 2610 12 glomerular glomerular JJ cord-015306-us58wwmp 2610 13 filtration filtration NN cord-015306-us58wwmp 2610 14 rate rate NN cord-015306-us58wwmp 2610 15 in in IN cord-015306-us58wwmp 2610 16 children child NNS cord-015306-us58wwmp 2610 17 of of IN cord-015306-us58wwmp 2610 18 this this DT cord-015306-us58wwmp 2610 19 age age NN cord-015306-us58wwmp 2610 20 . . . cord-015306-us58wwmp 2611 1 Microalbuminuria Microalbuminuria NNP cord-015306-us58wwmp 2611 2 Can Can MD cord-015306-us58wwmp 2612 1 Prognosticate prognosticate NN cord-015306-us58wwmp 2612 2 Outcome outcome NN cord-015306-us58wwmp 2612 3 In in IN cord-015306-us58wwmp 2612 4 The the DT cord-015306-us58wwmp 2612 5 Critically Critically NNP cord-015306-us58wwmp 2612 6 Ill Ill NNP cord-015306-us58wwmp 2612 7 Children Children NNPS cord-015306-us58wwmp 2612 8 Biplab Biplab NNP cord-015306-us58wwmp 2612 9 Maji Maji NNP cord-015306-us58wwmp 2612 10 , , , cord-015306-us58wwmp 2612 11 Surupa Surupa NNP cord-015306-us58wwmp 2612 12 Basu Basu NNP cord-015306-us58wwmp 2612 13 , , , cord-015306-us58wwmp 2612 14 Rajiv Rajiv NNP cord-015306-us58wwmp 2612 15 Sinha Sinha NNP cord-015306-us58wwmp 2612 16 Paediatrics Paediatrics NNP cord-015306-us58wwmp 2612 17 , , , cord-015306-us58wwmp 2612 18 Post Post NNP cord-015306-us58wwmp 2612 19 Graduate Graduate NNP cord-015306-us58wwmp 2612 20 Trainee Trainee NNP cord-015306-us58wwmp 2612 21 , , , cord-015306-us58wwmp 2612 22 Kolkata Kolkata NNP cord-015306-us58wwmp 2612 23 , , , cord-015306-us58wwmp 2613 1 India India NNP cord-015306-us58wwmp 2613 2 Objective Objective NNP cord-015306-us58wwmp 2613 3 : : : cord-015306-us58wwmp 2614 1 Microalbuminuria Microalbuminuria NNP cord-015306-us58wwmp 2614 2 [ [ -LRB- cord-015306-us58wwmp 2614 3 albumin albumin NN cord-015306-us58wwmp 2614 4 creatinine creatinine NN cord-015306-us58wwmp 2614 5 ratio ratio NN cord-015306-us58wwmp 2614 6 ( ( -LRB- cord-015306-us58wwmp 2614 7 ACR ACR NNP cord-015306-us58wwmp 2614 8 ) ) -RRB- cord-015306-us58wwmp 2614 9 > > XX cord-015306-us58wwmp 2615 1 30 30 CD cord-015306-us58wwmp 2615 2 mg mg NN cord-015306-us58wwmp 2615 3 / / SYM cord-015306-us58wwmp 2615 4 g g NN cord-015306-us58wwmp 2615 5 ] ] -RRB- cord-015306-us58wwmp 2615 6 increases increase NNS cord-015306-us58wwmp 2615 7 in in IN cord-015306-us58wwmp 2615 8 acute acute JJ cord-015306-us58wwmp 2615 9 inflammatory inflammatory JJ cord-015306-us58wwmp 2615 10 conditions condition NNS cord-015306-us58wwmp 2615 11 as as IN cord-015306-us58wwmp 2615 12 a a DT cord-015306-us58wwmp 2615 13 result result NN cord-015306-us58wwmp 2615 14 of of IN cord-015306-us58wwmp 2615 15 glomerular glomerular JJ cord-015306-us58wwmp 2615 16 endothelial endothelial JJ cord-015306-us58wwmp 2615 17 dysfunction dysfunction NN cord-015306-us58wwmp 2615 18 . . . cord-015306-us58wwmp 2616 1 The the DT cord-015306-us58wwmp 2616 2 study study NN cord-015306-us58wwmp 2616 3 evaluated evaluate VBD cord-015306-us58wwmp 2616 4 its -PRON- PRP$ cord-015306-us58wwmp 2616 5 prognostic prognostic JJ cord-015306-us58wwmp 2616 6 potential potential NN cord-015306-us58wwmp 2616 7 in in IN cord-015306-us58wwmp 2616 8 the the DT cord-015306-us58wwmp 2616 9 critically critically RB cord-015306-us58wwmp 2616 10 ill ill JJ cord-015306-us58wwmp 2616 11 child child NN cord-015306-us58wwmp 2616 12 . . . cord-015306-us58wwmp 2617 1 Methods method NNS cord-015306-us58wwmp 2617 2 : : : cord-015306-us58wwmp 2618 1 An an DT cord-015306-us58wwmp 2618 2 ongoing ongoing JJ cord-015306-us58wwmp 2618 3 prospective prospective JJ cord-015306-us58wwmp 2618 4 observational observational JJ cord-015306-us58wwmp 2618 5 study study NN cord-015306-us58wwmp 2618 6 ( ( -LRB- cord-015306-us58wwmp 2618 7 Oct Oct NNP cord-015306-us58wwmp 2618 8 2012-Mar 2012-mar CD cord-015306-us58wwmp 2618 9 2012 2012 CD cord-015306-us58wwmp 2618 10 ) ) -RRB- cord-015306-us58wwmp 2618 11 of of IN cord-015306-us58wwmp 2618 12 random random JJ cord-015306-us58wwmp 2618 13 urine urine NN cord-015306-us58wwmp 2618 14 ACR ACR NNP cord-015306-us58wwmp 2618 15 ( ( -LRB- cord-015306-us58wwmp 2618 16 mg mg NN cord-015306-us58wwmp 2618 17 / / SYM cord-015306-us58wwmp 2618 18 g g NNP cord-015306-us58wwmp 2618 19 ) ) -RRB- cord-015306-us58wwmp 2618 20 estimated estimate VBN cord-015306-us58wwmp 2618 21 on on IN cord-015306-us58wwmp 2618 22 day1 day1 NNP cord-015306-us58wwmp 2618 23 and and CC cord-015306-us58wwmp 2618 24 day day NN cord-015306-us58wwmp 2618 25 3 3 CD cord-015306-us58wwmp 2618 26 of of IN cord-015306-us58wwmp 2618 27 pediatric pediatric JJ cord-015306-us58wwmp 2618 28 intensive intensive JJ cord-015306-us58wwmp 2618 29 care care NN cord-015306-us58wwmp 2618 30 unit unit NN cord-015306-us58wwmp 2618 31 ( ( -LRB- cord-015306-us58wwmp 2618 32 PICU PICU NNP cord-015306-us58wwmp 2618 33 ) ) -RRB- cord-015306-us58wwmp 2618 34 admission admission NN cord-015306-us58wwmp 2618 35 , , , cord-015306-us58wwmp 2618 36 of of IN cord-015306-us58wwmp 2618 37 a a DT cord-015306-us58wwmp 2618 38 tertiary tertiary JJ cord-015306-us58wwmp 2618 39 care care NN cord-015306-us58wwmp 2618 40 pediatric pediatric JJ cord-015306-us58wwmp 2618 41 hospital hospital NN cord-015306-us58wwmp 2618 42 . . . cord-015306-us58wwmp 2619 1 Demographic demographic JJ cord-015306-us58wwmp 2619 2 , , , cord-015306-us58wwmp 2619 3 laboratory laboratory NN cord-015306-us58wwmp 2619 4 data datum NNS cord-015306-us58wwmp 2619 5 , , , cord-015306-us58wwmp 2619 6 vasopressor vasopressor NN cord-015306-us58wwmp 2619 7 use use NN cord-015306-us58wwmp 2619 8 , , , cord-015306-us58wwmp 2619 9 mechanical mechanical JJ cord-015306-us58wwmp 2619 10 ventilation ventilation NN cord-015306-us58wwmp 2619 11 , , , cord-015306-us58wwmp 2619 12 length length NN cord-015306-us58wwmp 2619 13 of of IN cord-015306-us58wwmp 2619 14 stay stay NN cord-015306-us58wwmp 2619 15 , , , cord-015306-us58wwmp 2619 16 outcome outcome NN cord-015306-us58wwmp 2619 17 and and CC cord-015306-us58wwmp 2619 18 PELOD pelod NN cord-015306-us58wwmp 2619 19 scores score NNS cord-015306-us58wwmp 2619 20 were be VBD cord-015306-us58wwmp 2619 21 recorded record VBN cord-015306-us58wwmp 2619 22 . . . cord-015306-us58wwmp 2620 1 Results result NNS cord-015306-us58wwmp 2620 2 : : : cord-015306-us58wwmp 2620 3 Of of IN cord-015306-us58wwmp 2620 4 113 113 CD cord-015306-us58wwmp 2620 5 children child NNS cord-015306-us58wwmp 2620 6 , , , cord-015306-us58wwmp 2620 7 72 72 CD cord-015306-us58wwmp 2620 8 children child NNS cord-015306-us58wwmp 2620 9 ( ( -LRB- cord-015306-us58wwmp 2620 10 median median JJ cord-015306-us58wwmp 2620 11 age age NN cord-015306-us58wwmp 2620 12 4.5years 4.5years CD cord-015306-us58wwmp 2620 13 , , , cord-015306-us58wwmp 2620 14 68 68 CD cord-015306-us58wwmp 2620 15 % % NN cord-015306-us58wwmp 2620 16 male male NN cord-015306-us58wwmp 2620 17 ) ) -RRB- cord-015306-us58wwmp 2620 18 recruited recruit VBN cord-015306-us58wwmp 2620 19 . . . cord-015306-us58wwmp 2621 1 The the DT cord-015306-us58wwmp 2621 2 commonest common JJS cord-015306-us58wwmp 2621 3 cause cause NN cord-015306-us58wwmp 2621 4 of of IN cord-015306-us58wwmp 2621 5 admission admission NN cord-015306-us58wwmp 2621 6 was be VBD cord-015306-us58wwmp 2621 7 pneumonia pneumonia NN cord-015306-us58wwmp 2621 8 , , , cord-015306-us58wwmp 2621 9 infection infection NN cord-015306-us58wwmp 2621 10 associated associate VBD cord-015306-us58wwmp 2621 11 hemophagocytic hemophagocytic JJ cord-015306-us58wwmp 2621 12 lymphohistiocytosis lymphohistiocytosis NN cord-015306-us58wwmp 2621 13 followed follow VBN cord-015306-us58wwmp 2621 14 by by IN cord-015306-us58wwmp 2621 15 meningitis meningitis NN cord-015306-us58wwmp 2621 16 . . . cord-015306-us58wwmp 2622 1 Day1 Day1 NNP cord-015306-us58wwmp 2622 2 ACR ACR NNP cord-015306-us58wwmp 2622 3 ( ( -LRB- cord-015306-us58wwmp 2622 4 median median JJ cord-015306-us58wwmp 2622 5 70.8 70.8 CD cord-015306-us58wwmp 2622 6 mg mg NNP cord-015306-us58wwmp 2622 7 / / SYM cord-015306-us58wwmp 2622 8 g g NNP cord-015306-us58wwmp 2622 9 ) ) -RRB- cord-015306-us58wwmp 2622 10 significantly significantly RB cord-015306-us58wwmp 2622 11 correlated correlate VBD cord-015306-us58wwmp 2622 12 with with IN cord-015306-us58wwmp 2622 13 day day NN cord-015306-us58wwmp 2622 14 3 3 CD cord-015306-us58wwmp 2622 15 total total JJ cord-015306-us58wwmp 2622 16 leukocyte leukocyte NN cord-015306-us58wwmp 2622 17 count count NN cord-015306-us58wwmp 2622 18 ( ( -LRB- cord-015306-us58wwmp 2622 19 P=0.016 P=0.016 NNP cord-015306-us58wwmp 2622 20 ) ) -RRB- cord-015306-us58wwmp 2622 21 . . . cord-015306-us58wwmp 2623 1 Both both DT cord-015306-us58wwmp 2623 2 day day NN cord-015306-us58wwmp 2623 3 1 1 CD cord-015306-us58wwmp 2623 4 and and CC cord-015306-us58wwmp 2623 5 day day NN cord-015306-us58wwmp 2623 6 3 3 CD cord-015306-us58wwmp 2623 7 ACR ACR NNP cord-015306-us58wwmp 2623 8 correlated correlate VBD cord-015306-us58wwmp 2623 9 with with IN cord-015306-us58wwmp 2623 10 PELOD pelod NN cord-015306-us58wwmp 2623 11 scores score NNS cord-015306-us58wwmp 2623 12 [ [ -LRB- cord-015306-us58wwmp 2623 13 median median JJ cord-015306-us58wwmp 2623 14 8 8 CD cord-015306-us58wwmp 2623 15 ] ] -RRB- cord-015306-us58wwmp 2623 16 ( ( -LRB- cord-015306-us58wwmp 2623 17 P=0.002 P=0.002 NNP cord-015306-us58wwmp 2623 18 & & CC cord-015306-us58wwmp 2623 19 p= p= NNP cord-015306-us58wwmp 2623 20 0.003 0.003 CD cord-015306-us58wwmp 2623 21 respectively respectively RB cord-015306-us58wwmp 2623 22 ) ) -RRB- cord-015306-us58wwmp 2623 23 and and CC cord-015306-us58wwmp 2623 24 duration duration NN cord-015306-us58wwmp 2623 25 of of IN cord-015306-us58wwmp 2623 26 mechanical mechanical JJ cord-015306-us58wwmp 2623 27 ventilation ventilation NN cord-015306-us58wwmp 2623 28 ( ( -LRB- cord-015306-us58wwmp 2623 29 p=0.003 p=0.003 NNP cord-015306-us58wwmp 2623 30 and and CC cord-015306-us58wwmp 2623 31 p=0.001 p=0.001 NNP cord-015306-us58wwmp 2623 32 respectively respectively RB cord-015306-us58wwmp 2623 33 ) ) -RRB- cord-015306-us58wwmp 2623 34 . . . cord-015306-us58wwmp 2624 1 Both both DT cord-015306-us58wwmp 2624 2 median median JJ cord-015306-us58wwmp 2624 3 day day NN cord-015306-us58wwmp 2624 4 1 1 CD cord-015306-us58wwmp 2624 5 ACR ACR NNP cord-015306-us58wwmp 2624 6 , , , cord-015306-us58wwmp 2624 7 and and CC cord-015306-us58wwmp 2624 8 day day NN cord-015306-us58wwmp 2624 9 3 3 CD cord-015306-us58wwmp 2624 10 ACR ACR NNP cord-015306-us58wwmp 2624 11 were be VBD cord-015306-us58wwmp 2624 12 significantly significantly RB cord-015306-us58wwmp 2624 13 different different JJ cord-015306-us58wwmp 2624 14 between between IN cord-015306-us58wwmp 2624 15 survivors survivor NNS cord-015306-us58wwmp 2624 16 ( ( -LRB- cord-015306-us58wwmp 2624 17 n= n= NNP cord-015306-us58wwmp 2624 18 29 29 CD cord-015306-us58wwmp 2624 19 ) ) -RRB- cord-015306-us58wwmp 2624 20 and and CC cord-015306-us58wwmp 2624 21 non non NNS cord-015306-us58wwmp 2624 22 - - NNS cord-015306-us58wwmp 2624 23 survivors survivor NNS cord-015306-us58wwmp 2624 24 ( ( -LRB- cord-015306-us58wwmp 2624 25 n=11 n=11 NNP cord-015306-us58wwmp 2624 26 ) ) -RRB- cord-015306-us58wwmp 2624 27 ( ( -LRB- cord-015306-us58wwmp 2624 28 p=0.0001 p=0.0001 NNS cord-015306-us58wwmp 2624 29 and and CC cord-015306-us58wwmp 2624 30 p<0.0001 p<0.0001 NNP cord-015306-us58wwmp 2624 31 , , , cord-015306-us58wwmp 2624 32 respectively respectively RB cord-015306-us58wwmp 2624 33 ) ) -RRB- cord-015306-us58wwmp 2624 34 . . . cord-015306-us58wwmp 2625 1 ROC ROC NNP cord-015306-us58wwmp 2625 2 curve curve NN cord-015306-us58wwmp 2625 3 analysis analysis NN cord-015306-us58wwmp 2625 4 for for IN cord-015306-us58wwmp 2625 5 mortality mortality NN cord-015306-us58wwmp 2625 6 prediction prediction NN cord-015306-us58wwmp 2625 7 revealed reveal VBD cord-015306-us58wwmp 2625 8 the the DT cord-015306-us58wwmp 2625 9 highest high JJS cord-015306-us58wwmp 2625 10 area area NN cord-015306-us58wwmp 2625 11 under under IN cord-015306-us58wwmp 2625 12 curve curve NN cord-015306-us58wwmp 2625 13 ( ( -LRB- cord-015306-us58wwmp 2625 14 AuC auc NN cord-015306-us58wwmp 2625 15 ) ) -RRB- cord-015306-us58wwmp 2625 16 of of IN cord-015306-us58wwmp 2625 17 0.963 0.963 CD cord-015306-us58wwmp 2625 18 for for IN cord-015306-us58wwmp 2625 19 ACR3 ACR3 NNP cord-015306-us58wwmp 2625 20 , , , cord-015306-us58wwmp 2625 21 followed follow VBN cord-015306-us58wwmp 2625 22 by by IN cord-015306-us58wwmp 2625 23 0.928 0.928 CD cord-015306-us58wwmp 2625 24 for for IN cord-015306-us58wwmp 2625 25 ACR1 ACR1 NNP cord-015306-us58wwmp 2625 26 and and CC cord-015306-us58wwmp 2625 27 0.867 0.867 CD cord-015306-us58wwmp 2625 28 for for IN cord-015306-us58wwmp 2625 29 PELOD PELOD NNP cord-015306-us58wwmp 2625 30 scoring score VBG cord-015306-us58wwmp 2625 31 ( ( -LRB- cord-015306-us58wwmp 2625 32 p>0.05 p>0.05 NNP cord-015306-us58wwmp 2625 33 , , , cord-015306-us58wwmp 2625 34 non non JJ cord-015306-us58wwmp 2625 35 - - JJ cord-015306-us58wwmp 2625 36 significant significant JJ cord-015306-us58wwmp 2625 37 for for IN cord-015306-us58wwmp 2625 38 AuC auc NN cord-015306-us58wwmp 2625 39 comparisions comparision NNS cord-015306-us58wwmp 2625 40 ) ) -RRB- cord-015306-us58wwmp 2626 1 ( ( -LRB- cord-015306-us58wwmp 2626 2 Fig Fig NNP cord-015306-us58wwmp 2626 3 . . . cord-015306-us58wwmp 2627 1 1 1 LS cord-015306-us58wwmp 2627 2 . . . cord-015306-us58wwmp 2627 3 ) ) -RRB- cord-015306-us58wwmp 2627 4 . . . cord-015306-us58wwmp 2628 1 A a DT cord-015306-us58wwmp 2628 2 cut cut VB cord-015306-us58wwmp 2628 3 - - HYPH cord-015306-us58wwmp 2628 4 off off RP cord-015306-us58wwmp 2628 5 value value NN cord-015306-us58wwmp 2628 6 of of IN cord-015306-us58wwmp 2628 7 day day NN cord-015306-us58wwmp 2628 8 3 3 CD cord-015306-us58wwmp 2628 9 ACR ACR NNP cord-015306-us58wwmp 2628 10 of of IN cord-015306-us58wwmp 2628 11 102.4mg 102.4mg CD cord-015306-us58wwmp 2628 12 / / SYM cord-015306-us58wwmp 2628 13 g g NN cord-015306-us58wwmp 2628 14 had have VBD cord-015306-us58wwmp 2628 15 a a DT cord-015306-us58wwmp 2628 16 positive positive JJ cord-015306-us58wwmp 2628 17 predictive predictive JJ cord-015306-us58wwmp 2628 18 value value NN cord-015306-us58wwmp 2628 19 of of IN cord-015306-us58wwmp 2628 20 95.8 95.8 CD cord-015306-us58wwmp 2628 21 % % NN cord-015306-us58wwmp 2628 22 for for IN cord-015306-us58wwmp 2628 23 negative negative JJ cord-015306-us58wwmp 2628 24 outcome outcome NN cord-015306-us58wwmp 2628 25 Conclusion conclusion NN cord-015306-us58wwmp 2628 26 : : : cord-015306-us58wwmp 2629 1 Microalbuminuria Microalbuminuria NNP cord-015306-us58wwmp 2629 2 is be VBZ cord-015306-us58wwmp 2629 3 an an DT cord-015306-us58wwmp 2629 4 early early JJ cord-015306-us58wwmp 2629 5 inflammatory inflammatory JJ cord-015306-us58wwmp 2629 6 marker marker NN cord-015306-us58wwmp 2629 7 that that WDT cord-015306-us58wwmp 2629 8 correlates correlate VBZ cord-015306-us58wwmp 2629 9 with with IN cord-015306-us58wwmp 2629 10 organ organ NN cord-015306-us58wwmp 2629 11 dysfunction dysfunction NN cord-015306-us58wwmp 2629 12 . . . cord-015306-us58wwmp 2630 1 Significant significant JJ cord-015306-us58wwmp 2630 2 levels level NNS cord-015306-us58wwmp 2630 3 reliably reliably RB cord-015306-us58wwmp 2630 4 predict predict VBP cord-015306-us58wwmp 2630 5 negative negative JJ cord-015306-us58wwmp 2630 6 outcome outcome NN cord-015306-us58wwmp 2630 7 early early RB cord-015306-us58wwmp 2630 8 into into IN cord-015306-us58wwmp 2630 9 intensive intensive JJ cord-015306-us58wwmp 2630 10 care care NN cord-015306-us58wwmp 2630 11 admission admission NN cord-015306-us58wwmp 2630 12 , , , cord-015306-us58wwmp 2630 13 as as RB cord-015306-us58wwmp 2630 14 accurately accurately RB cord-015306-us58wwmp 2630 15 as as IN cord-015306-us58wwmp 2630 16 PELOD PELOD NNP cord-015306-us58wwmp 2630 17 scores score NNS cord-015306-us58wwmp 2630 18 , , , cord-015306-us58wwmp 2630 19 which which WDT cord-015306-us58wwmp 2630 20 can can MD cord-015306-us58wwmp 2630 21 help help VB cord-015306-us58wwmp 2630 22 counsel counsel VB cord-015306-us58wwmp 2630 23 patients patient NNS cord-015306-us58wwmp 2630 24 , , , cord-015306-us58wwmp 2630 25 plan plan VBP cord-015306-us58wwmp 2630 26 treatment treatment NN cord-015306-us58wwmp 2630 27 and and CC cord-015306-us58wwmp 2630 28 triage triage NN cord-015306-us58wwmp 2630 29 , , , cord-015306-us58wwmp 2630 30 and and CC cord-015306-us58wwmp 2630 31 allocate allocate VB cord-015306-us58wwmp 2630 32 resources resource NNS cord-015306-us58wwmp 2630 33 judiciously judiciously RB cord-015306-us58wwmp 2630 34 . . . cord-015306-us58wwmp 2631 1 Abstract abstract JJ cord-015306-us58wwmp 2631 2 # # NN cord-015306-us58wwmp 2632 1 P p NN cord-015306-us58wwmp 2632 2 - - HYPH cord-015306-us58wwmp 2632 3 SAT314 sat314 NN cord-015306-us58wwmp 2633 1 An an DT cord-015306-us58wwmp 2633 2 unusual unusual JJ cord-015306-us58wwmp 2633 3 presentation presentation NN cord-015306-us58wwmp 2633 4 of of IN cord-015306-us58wwmp 2633 5 congenital congenital JJ cord-015306-us58wwmp 2633 6 nephrotic nephrotic JJ cord-015306-us58wwmp 2633 7 syndrome syndrome NN cord-015306-us58wwmp 2633 8 caused cause VBN cord-015306-us58wwmp 2633 9 by by IN cord-015306-us58wwmp 2633 10 WT1 WT1 NNP cord-015306-us58wwmp 2633 11 mutation mutation NN cord-015306-us58wwmp 2633 12 Ann Ann NNP cord-015306-us58wwmp 2633 13 Raes Raes NNP cord-015306-us58wwmp 2633 14 , , , cord-015306-us58wwmp 2633 15 Sofie Sofie NNP cord-015306-us58wwmp 2633 16 Maebe Maebe NNP cord-015306-us58wwmp 2633 17 , , , cord-015306-us58wwmp 2633 18 Joke Joke NNP cord-015306-us58wwmp 2633 19 Dehoorne Dehoorne NNP cord-015306-us58wwmp 2633 20 , , , cord-015306-us58wwmp 2633 21 Bert Bert NNP cord-015306-us58wwmp 2633 22 Callewaert Callewaert NNP cord-015306-us58wwmp 2633 23 , , , cord-015306-us58wwmp 2633 24 Johan Johan NNP cord-015306-us58wwmp 2633 25 Vande Vande NNP cord-015306-us58wwmp 2633 26 Walle Walle NNP cord-015306-us58wwmp 2633 27 Pediatric Pediatric NNP cord-015306-us58wwmp 2633 28 Nephrology Nephrology NNP cord-015306-us58wwmp 2633 29 , , , cord-015306-us58wwmp 2633 30 University University NNP cord-015306-us58wwmp 2633 31 Hospital Hospital NNP cord-015306-us58wwmp 2633 32 , , , cord-015306-us58wwmp 2633 33 Gent Gent NNP cord-015306-us58wwmp 2633 34 , , , cord-015306-us58wwmp 2633 35 Belgium Belgium NNP cord-015306-us58wwmp 2633 36 Objective Objective NNP cord-015306-us58wwmp 2633 37 , , , cord-015306-us58wwmp 2633 38 Methods Methods NNPS cord-015306-us58wwmp 2633 39 and and CC cord-015306-us58wwmp 2633 40 Results result NNS cord-015306-us58wwmp 2633 41 : : : cord-015306-us58wwmp 2633 42 A a DT cord-015306-us58wwmp 2633 43 Caucasian caucasian JJ cord-015306-us58wwmp 2633 44 girl girl NN cord-015306-us58wwmp 2633 45 was be VBD cord-015306-us58wwmp 2633 46 admitted admit VBN cord-015306-us58wwmp 2633 47 at at IN cord-015306-us58wwmp 2633 48 the the DT cord-015306-us58wwmp 2633 49 age age NN cord-015306-us58wwmp 2633 50 of of IN cord-015306-us58wwmp 2633 51 28 28 CD cord-015306-us58wwmp 2633 52 days day NNS cord-015306-us58wwmp 2633 53 because because IN cord-015306-us58wwmp 2633 54 of of IN cord-015306-us58wwmp 2633 55 progressive progressive JJ cord-015306-us58wwmp 2633 56 lethargy lethargy NN cord-015306-us58wwmp 2633 57 , , , cord-015306-us58wwmp 2633 58 poor poor JJ cord-015306-us58wwmp 2633 59 feeding feeding NN cord-015306-us58wwmp 2633 60 , , , cord-015306-us58wwmp 2633 61 oliguria oliguria FW cord-015306-us58wwmp 2633 62 en en FW cord-015306-us58wwmp 2633 63 peri peri JJ cord-015306-us58wwmp 2633 64 - - HYPH cord-015306-us58wwmp 2633 65 orbital orbital JJ cord-015306-us58wwmp 2633 66 edema edema NN cord-015306-us58wwmp 2633 67 . . . cord-015306-us58wwmp 2634 1 extreme extreme JJ cord-015306-us58wwmp 2634 2 hyponatremia hyponatremia NN cord-015306-us58wwmp 2634 3 ( ( -LRB- cord-015306-us58wwmp 2634 4 89 89 CD cord-015306-us58wwmp 2634 5 mmol mmol JJ cord-015306-us58wwmp 2634 6 / / SYM cord-015306-us58wwmp 2634 7 L L NNP cord-015306-us58wwmp 2634 8 ) ) -RRB- cord-015306-us58wwmp 2634 9 , , , cord-015306-us58wwmp 2634 10 severe severe JJ cord-015306-us58wwmp 2634 11 renal renal JJ cord-015306-us58wwmp 2634 12 insufficiency insufficiency NN cord-015306-us58wwmp 2634 13 ( ( -LRB- cord-015306-us58wwmp 2634 14 creat creat VB cord-015306-us58wwmp 2634 15 1.9 1.9 CD cord-015306-us58wwmp 2634 16 mg mg NNP cord-015306-us58wwmp 2634 17 / / SYM cord-015306-us58wwmp 2634 18 dl dl NNP cord-015306-us58wwmp 2634 19 , , , cord-015306-us58wwmp 2634 20 P P NNP cord-015306-us58wwmp 2634 21 10.7 10.7 CD cord-015306-us58wwmp 2634 22 mg mg NNP cord-015306-us58wwmp 2634 23 / / SYM cord-015306-us58wwmp 2634 24 dl dl NNP cord-015306-us58wwmp 2634 25 ) ) -RRB- cord-015306-us58wwmp 2634 26 , , , cord-015306-us58wwmp 2634 27 low low JJ cord-015306-us58wwmp 2634 28 plasma plasma NN cord-015306-us58wwmp 2634 29 albumin albumin NN cord-015306-us58wwmp 2634 30 ( ( -LRB- cord-015306-us58wwmp 2634 31 1.5 1.5 CD cord-015306-us58wwmp 2634 32 g g NN cord-015306-us58wwmp 2634 33 / / SYM cord-015306-us58wwmp 2634 34 dl dl NN cord-015306-us58wwmp 2634 35 ) ) -RRB- cord-015306-us58wwmp 2634 36 , , , cord-015306-us58wwmp 2634 37 respiratory respiratory JJ cord-015306-us58wwmp 2634 38 compensated compensate VBN cord-015306-us58wwmp 2634 39 metabolic metabolic JJ cord-015306-us58wwmp 2634 40 acidosis acidosis NN cord-015306-us58wwmp 2634 41 ( ( -LRB- cord-015306-us58wwmp 2634 42 arterial arterial JJ cord-015306-us58wwmp 2634 43 pH pH NNP cord-015306-us58wwmp 2634 44 7.31 7.31 CD cord-015306-us58wwmp 2634 45 pCO pco CD cord-015306-us58wwmp 2634 46 2 2 CD cord-015306-us58wwmp 2634 47 27 27 CD cord-015306-us58wwmp 2634 48 mmHg mmHg NNS cord-015306-us58wwmp 2634 49 , , , cord-015306-us58wwmp 2634 50 bicarbonate bicarbonate NN cord-015306-us58wwmp 2634 51 13.5 13.5 CD cord-015306-us58wwmp 2634 52 mmol mmol NNP cord-015306-us58wwmp 2634 53 / / SYM cord-015306-us58wwmp 2634 54 L L NNP cord-015306-us58wwmp 2634 55 , , , cord-015306-us58wwmp 2634 56 BE be VB cord-015306-us58wwmp 2634 57 -10.9 -10.9 IN cord-015306-us58wwmp 2634 58 mmol mmol NN cord-015306-us58wwmp 2634 59 / / SYM cord-015306-us58wwmp 2634 60 L L NNP cord-015306-us58wwmp 2634 61 ) ) -RRB- cord-015306-us58wwmp 2634 62 and and CC cord-015306-us58wwmp 2634 63 massive massive JJ cord-015306-us58wwmp 2634 64 proteinuria proteinuria NN cord-015306-us58wwmp 2634 65 ( ( -LRB- cord-015306-us58wwmp 2634 66 12 12 CD cord-015306-us58wwmp 2634 67 g g NN cord-015306-us58wwmp 2634 68 / / SYM cord-015306-us58wwmp 2634 69 L L NNP cord-015306-us58wwmp 2634 70 ) ) -RRB- cord-015306-us58wwmp 2634 71 . . . cord-015306-us58wwmp 2635 1 Clinical clinical JJ cord-015306-us58wwmp 2635 2 examination examination NN cord-015306-us58wwmp 2635 3 was be VBD cord-015306-us58wwmp 2635 4 normal normal JJ cord-015306-us58wwmp 2635 5 without without IN cord-015306-us58wwmp 2635 6 anomalies anomaly NNS cord-015306-us58wwmp 2635 7 of of IN cord-015306-us58wwmp 2635 8 the the DT cord-015306-us58wwmp 2635 9 external external JJ cord-015306-us58wwmp 2635 10 genitals genital NNS cord-015306-us58wwmp 2635 11 or or CC cord-015306-us58wwmp 2635 12 other other JJ cord-015306-us58wwmp 2635 13 dysmorphic dysmorphic JJ cord-015306-us58wwmp 2635 14 features feature NNS cord-015306-us58wwmp 2635 15 . . . cord-015306-us58wwmp 2636 1 Despite despite IN cord-015306-us58wwmp 2636 2 supportive supportive JJ cord-015306-us58wwmp 2636 3 therapy therapy NN cord-015306-us58wwmp 2636 4 ( ( -LRB- cord-015306-us58wwmp 2636 5 sodium sodium NN cord-015306-us58wwmp 2636 6 , , , cord-015306-us58wwmp 2636 7 bicarbonate bicarbonate NN cord-015306-us58wwmp 2636 8 , , , cord-015306-us58wwmp 2636 9 albumin albumin NN cord-015306-us58wwmp 2636 10 and and CC cord-015306-us58wwmp 2636 11 furosemide furosemide NN cord-015306-us58wwmp 2636 12 ) ) -RRB- cord-015306-us58wwmp 2637 1 she -PRON- PRP cord-015306-us58wwmp 2637 2 progressed progress VBD cord-015306-us58wwmp 2637 3 to to IN cord-015306-us58wwmp 2637 4 respiratory respiratory JJ cord-015306-us58wwmp 2637 5 failure failure NN cord-015306-us58wwmp 2637 6 and and CC cord-015306-us58wwmp 2637 7 renal renal JJ cord-015306-us58wwmp 2637 8 failure failure NN cord-015306-us58wwmp 2637 9 with with IN cord-015306-us58wwmp 2637 10 need need NN cord-015306-us58wwmp 2637 11 for for IN cord-015306-us58wwmp 2637 12 mechanical mechanical JJ cord-015306-us58wwmp 2637 13 ventilation ventilation NN cord-015306-us58wwmp 2637 14 and and CC cord-015306-us58wwmp 2637 15 peritoneal peritoneal JJ cord-015306-us58wwmp 2637 16 dialysis dialysis NN cord-015306-us58wwmp 2637 17 . . . cord-015306-us58wwmp 2638 1 Congenital congenital JJ cord-015306-us58wwmp 2638 2 infections infection NNS cord-015306-us58wwmp 2638 3 and and CC cord-015306-us58wwmp 2638 4 thrombosis thrombosis NN cord-015306-us58wwmp 2638 5 was be VBD cord-015306-us58wwmp 2638 6 ruled rule VBN cord-015306-us58wwmp 2638 7 out out RP cord-015306-us58wwmp 2638 8 . . . cord-015306-us58wwmp 2639 1 Histological histological JJ cord-015306-us58wwmp 2639 2 examination examination NN cord-015306-us58wwmp 2639 3 showed show VBD cord-015306-us58wwmp 2639 4 diffuse diffuse JJ cord-015306-us58wwmp 2639 5 mesangial mesangial JJ cord-015306-us58wwmp 2639 6 sclerosis sclerosis NN cord-015306-us58wwmp 2639 7 ( ( -LRB- cord-015306-us58wwmp 2639 8 DMS DMS NNP cord-015306-us58wwmp 2639 9 ) ) -RRB- cord-015306-us58wwmp 2639 10 . . . cord-015306-us58wwmp 2640 1 The the DT cord-015306-us58wwmp 2640 2 combination combination NN cord-015306-us58wwmp 2640 3 of of IN cord-015306-us58wwmp 2640 4 congenital congenital JJ cord-015306-us58wwmp 2640 5 nephritic nephritic JJ cord-015306-us58wwmp 2640 6 syndrome syndrome NN cord-015306-us58wwmp 2640 7 and and CC cord-015306-us58wwmp 2640 8 DMS DMS NNP cord-015306-us58wwmp 2640 9 on on IN cord-015306-us58wwmp 2640 10 biopsy biopsy NN cord-015306-us58wwmp 2640 11 was be VBD cord-015306-us58wwmp 2640 12 suggestive suggestive JJ cord-015306-us58wwmp 2640 13 for for IN cord-015306-us58wwmp 2640 14 mutations mutation NNS cord-015306-us58wwmp 2640 15 in in IN cord-015306-us58wwmp 2640 16 the the DT cord-015306-us58wwmp 2640 17 Wilms Wilms NNP cord-015306-us58wwmp 2640 18 ' ' POS cord-015306-us58wwmp 2640 19 Tumor tumor NN cord-015306-us58wwmp 2640 20 1 1 CD cord-015306-us58wwmp 2640 21 ( ( -LRB- cord-015306-us58wwmp 2640 22 WT1 wt1 NN cord-015306-us58wwmp 2640 23 ) ) -RRB- cord-015306-us58wwmp 2640 24 gene gene NN cord-015306-us58wwmp 2640 25 . . . cord-015306-us58wwmp 2641 1 Genetic genetic JJ cord-015306-us58wwmp 2641 2 analysis analysis NN cord-015306-us58wwmp 2641 3 showed show VBD cord-015306-us58wwmp 2641 4 normal normal JJ cord-015306-us58wwmp 2641 5 female female JJ cord-015306-us58wwmp 2641 6 karyotype karyotype NN cord-015306-us58wwmp 2641 7 and and CC cord-015306-us58wwmp 2641 8 conformed conform VBD cord-015306-us58wwmp 2641 9 a a DT cord-015306-us58wwmp 2641 10 heterozygosity heterozygosity NN cord-015306-us58wwmp 2641 11 for for IN cord-015306-us58wwmp 2641 12 the the DT cord-015306-us58wwmp 2641 13 c.1223c c.1223c NNP cord-015306-us58wwmp 2641 14 > > XX cord-015306-us58wwmp 2641 15 G G NNP cord-015306-us58wwmp 2641 16 or or CC cord-015306-us58wwmp 2641 17 p. p. NN cord-015306-us58wwmp 2642 1 His441Gln his441gln DT cord-015306-us58wwmp 2642 2 mutation mutation NN cord-015306-us58wwmp 2642 3 within within IN cord-015306-us58wwmp 2642 4 the the DT cord-015306-us58wwmp 2642 5 Zinc zinc NN cord-015306-us58wwmp 2642 6 finger finger NN cord-015306-us58wwmp 2642 7 2 2 CD cord-015306-us58wwmp 2642 8 domain domain NN cord-015306-us58wwmp 2642 9 . . . cord-015306-us58wwmp 2643 1 After after IN cord-015306-us58wwmp 2643 2 a a DT cord-015306-us58wwmp 2643 3 long long JJ cord-015306-us58wwmp 2643 4 and and CC cord-015306-us58wwmp 2643 5 complicated complicated JJ cord-015306-us58wwmp 2643 6 ICU ICU NNP cord-015306-us58wwmp 2643 7 episode episode NN cord-015306-us58wwmp 2643 8 , , , cord-015306-us58wwmp 2643 9 a a DT cord-015306-us58wwmp 2643 10 stable stable JJ cord-015306-us58wwmp 2643 11 situation situation NN cord-015306-us58wwmp 2643 12 with with IN cord-015306-us58wwmp 2643 13 home home NN cord-015306-us58wwmp 2643 14 choice choice NN cord-015306-us58wwmp 2643 15 peritoneal peritoneal JJ cord-015306-us58wwmp 2643 16 dialysis dialysis NN cord-015306-us58wwmp 2643 17 was be VBD cord-015306-us58wwmp 2643 18 achieved achieve VBN cord-015306-us58wwmp 2643 19 . . . cord-015306-us58wwmp 2644 1 Due due IN cord-015306-us58wwmp 2644 2 to to IN cord-015306-us58wwmp 2644 3 the the DT cord-015306-us58wwmp 2644 4 important important JJ cord-015306-us58wwmp 2644 5 risk risk NN cord-015306-us58wwmp 2644 6 for for IN cord-015306-us58wwmp 2644 7 comparision comparision NN cord-015306-us58wwmp 2644 8 of of IN cord-015306-us58wwmp 2644 9 AuC auc NN cord-015306-us58wwmp 2644 10 of of IN cord-015306-us58wwmp 2644 11 PELOD PELOD NNP cord-015306-us58wwmp 2644 12 with with IN cord-015306-us58wwmp 2644 13 ACR ACR NNP cord-015306-us58wwmp 2644 14 3 3 CD cord-015306-us58wwmp 2644 15 , , , cord-015306-us58wwmp 2644 16 p= p= NNP cord-015306-us58wwmp 2644 17 0.766 0.766 CD cord-015306-us58wwmp 2644 18 for for IN cord-015306-us58wwmp 2644 19 comparison comparison NN cord-015306-us58wwmp 2644 20 with with IN cord-015306-us58wwmp 2644 21 ACR ACR NNP cord-015306-us58wwmp 2644 22 1 1 CD cord-015306-us58wwmp 2644 23 ) ) -RRB- cord-015306-us58wwmp 2644 24 for for IN cord-015306-us58wwmp 2644 25 the the DT cord-015306-us58wwmp 2644 26 prediction prediction NN cord-015306-us58wwmp 2644 27 of of IN cord-015306-us58wwmp 2644 28 mortality mortality NN cord-015306-us58wwmp 2644 29 in in IN cord-015306-us58wwmp 2644 30 the the DT cord-015306-us58wwmp 2644 31 pediatric pediatric JJ cord-015306-us58wwmp 2644 32 intensive intensive JJ cord-015306-us58wwmp 2644 33 care care NN cord-015306-us58wwmp 2644 34 unit unit NN cord-015306-us58wwmp 2644 35 . . . cord-015306-us58wwmp 2645 1 development development NN cord-015306-us58wwmp 2645 2 of of IN cord-015306-us58wwmp 2645 3 Wilms Wilms NNP cord-015306-us58wwmp 2645 4 ' ' POS cord-015306-us58wwmp 2645 5 tumor tumor NN cord-015306-us58wwmp 2645 6 , , , cord-015306-us58wwmp 2645 7 bilateral bilateral JJ cord-015306-us58wwmp 2645 8 nefrectomy nefrectomy NN cord-015306-us58wwmp 2645 9 was be VBD cord-015306-us58wwmp 2645 10 performed perform VBN cord-015306-us58wwmp 2645 11 and and CC cord-015306-us58wwmp 2645 12 kidney kidney NN cord-015306-us58wwmp 2645 13 transplantation transplantation NN cord-015306-us58wwmp 2645 14 will will MD cord-015306-us58wwmp 2645 15 be be VB cord-015306-us58wwmp 2645 16 planned plan VBN cord-015306-us58wwmp 2645 17 . . . cord-015306-us58wwmp 2646 1 We -PRON- PRP cord-015306-us58wwmp 2646 2 present present VBP cord-015306-us58wwmp 2646 3 an an DT cord-015306-us58wwmp 2646 4 unusual unusual JJ cord-015306-us58wwmp 2646 5 case case NN cord-015306-us58wwmp 2646 6 of of IN cord-015306-us58wwmp 2646 7 congenital congenital JJ cord-015306-us58wwmp 2646 8 nephrotic nephrotic JJ cord-015306-us58wwmp 2646 9 syndrome syndrome NN cord-015306-us58wwmp 2646 10 with with IN cord-015306-us58wwmp 2646 11 extreme extreme JJ cord-015306-us58wwmp 2646 12 hyponatremia hyponatremia NN cord-015306-us58wwmp 2646 13 at at IN cord-015306-us58wwmp 2646 14 presentation presentation NN cord-015306-us58wwmp 2646 15 and and CC cord-015306-us58wwmp 2646 16 fast fast JJ cord-015306-us58wwmp 2646 17 progression progression NN cord-015306-us58wwmp 2646 18 to to IN cord-015306-us58wwmp 2646 19 ESRD ESRD NNP cord-015306-us58wwmp 2646 20 , , , cord-015306-us58wwmp 2646 21 due due IN cord-015306-us58wwmp 2646 22 to to IN cord-015306-us58wwmp 2646 23 mutation mutation NN cord-015306-us58wwmp 2646 24 in in IN cord-015306-us58wwmp 2646 25 WT1 WT1 NNP cord-015306-us58wwmp 2646 26 gene gene NN cord-015306-us58wwmp 2646 27 . . . cord-015306-us58wwmp 2647 1 Several several JJ cord-015306-us58wwmp 2647 2 genes gene NNS cord-015306-us58wwmp 2647 3 have have VBP cord-015306-us58wwmp 2647 4 been be VBN cord-015306-us58wwmp 2647 5 implicated implicate VBN cord-015306-us58wwmp 2647 6 in in IN cord-015306-us58wwmp 2647 7 congenital congenital JJ cord-015306-us58wwmp 2647 8 nephrotic nephrotic JJ cord-015306-us58wwmp 2647 9 syndrome syndrome NN cord-015306-us58wwmp 2647 10 . . . cord-015306-us58wwmp 2648 1 Genetic genetic JJ cord-015306-us58wwmp 2648 2 testing testing NN cord-015306-us58wwmp 2648 3 is be VBZ cord-015306-us58wwmp 2648 4 mandatory mandatory JJ cord-015306-us58wwmp 2648 5 and and CC cord-015306-us58wwmp 2648 6 can can MD cord-015306-us58wwmp 2648 7 add add VB cord-015306-us58wwmp 2648 8 important important JJ cord-015306-us58wwmp 2648 9 information information NN cord-015306-us58wwmp 2648 10 such such JJ cord-015306-us58wwmp 2648 11 as as IN cord-015306-us58wwmp 2648 12 risk risk NN cord-015306-us58wwmp 2648 13 of of IN cord-015306-us58wwmp 2648 14 malignancy malignancy NN cord-015306-us58wwmp 2648 15 . . . cord-015306-us58wwmp 2649 1 Renal renal JJ cord-015306-us58wwmp 2649 2 histology histology NN cord-015306-us58wwmp 2649 3 can can MD cord-015306-us58wwmp 2649 4 play play VB cord-015306-us58wwmp 2649 5 an an DT cord-015306-us58wwmp 2649 6 important important JJ cord-015306-us58wwmp 2649 7 role role NN cord-015306-us58wwmp 2649 8 in in IN cord-015306-us58wwmp 2649 9 the the DT cord-015306-us58wwmp 2649 10 approach approach NN cord-015306-us58wwmp 2649 11 for for IN cord-015306-us58wwmp 2649 12 appropriate appropriate JJ cord-015306-us58wwmp 2649 13 mutational mutational JJ cord-015306-us58wwmp 2649 14 screening screening NN cord-015306-us58wwmp 2649 15 . . . cord-015306-us58wwmp 2650 1 Mutations mutation NNS cord-015306-us58wwmp 2650 2 in in IN cord-015306-us58wwmp 2650 3 the the DT cord-015306-us58wwmp 2650 4 WT1 WT1 NNP cord-015306-us58wwmp 2650 5 gene gene NN cord-015306-us58wwmp 2650 6 are be VBP cord-015306-us58wwmp 2650 7 associated associate VBN cord-015306-us58wwmp 2650 8 with with IN cord-015306-us58wwmp 2650 9 Denish Denish NNP cord-015306-us58wwmp 2650 10 Drash Drash NNP cord-015306-us58wwmp 2650 11 syndrome syndrome NN cord-015306-us58wwmp 2650 12 and and CC cord-015306-us58wwmp 2650 13 Frasier Frasier NNP cord-015306-us58wwmp 2650 14 syndrome syndrome NN cord-015306-us58wwmp 2650 15 , , , cord-015306-us58wwmp 2650 16 but but CC cord-015306-us58wwmp 2650 17 also also RB cord-015306-us58wwmp 2650 18 with with IN cord-015306-us58wwmp 2650 19 isolated isolated JJ cord-015306-us58wwmp 2650 20 and and CC cord-015306-us58wwmp 2650 21 sporadic sporadic JJ cord-015306-us58wwmp 2650 22 steroid steroid JJ cord-015306-us58wwmp 2650 23 resistant resistant JJ cord-015306-us58wwmp 2650 24 nephrotic nephrotic JJ cord-015306-us58wwmp 2650 25 syndrome syndrome NN cord-015306-us58wwmp 2650 26 . . . cord-015306-us58wwmp 2651 1 In in IN cord-015306-us58wwmp 2651 2 the the DT cord-015306-us58wwmp 2651 3 last last JJ cord-015306-us58wwmp 2651 4 category category NN cord-015306-us58wwmp 2651 5 the the DT cord-015306-us58wwmp 2651 6 majority majority NN cord-015306-us58wwmp 2651 7 of of IN cord-015306-us58wwmp 2651 8 patients patient NNS cord-015306-us58wwmp 2651 9 is be VBZ cord-015306-us58wwmp 2651 10 female female JJ cord-015306-us58wwmp 2651 11 , , , cord-015306-us58wwmp 2651 12 the the DT cord-015306-us58wwmp 2651 13 age age NN cord-015306-us58wwmp 2651 14 of of IN cord-015306-us58wwmp 2651 15 onset onset NN cord-015306-us58wwmp 2651 16 and and CC cord-015306-us58wwmp 2651 17 time time NN cord-015306-us58wwmp 2651 18 to to IN cord-015306-us58wwmp 2651 19 ESRD ESRD NNP cord-015306-us58wwmp 2651 20 is be VBZ cord-015306-us58wwmp 2651 21 variable variable JJ cord-015306-us58wwmp 2651 22 , , , cord-015306-us58wwmp 2651 23 although although IN cord-015306-us58wwmp 2651 24 the the DT cord-015306-us58wwmp 2651 25 vast vast JJ cord-015306-us58wwmp 2651 26 majority majority NN cord-015306-us58wwmp 2651 27 of of IN cord-015306-us58wwmp 2651 28 cases case NNS cord-015306-us58wwmp 2651 29 are be VBP cord-015306-us58wwmp 2651 30 older old JJR cord-015306-us58wwmp 2651 31 at at IN cord-015306-us58wwmp 2651 32 presentation presentation NN cord-015306-us58wwmp 2651 33 and and CC cord-015306-us58wwmp 2651 34 time time NN cord-015306-us58wwmp 2651 35 to to IN cord-015306-us58wwmp 2651 36 ESRD ESRD NNP cord-015306-us58wwmp 2651 37 is be VBZ cord-015306-us58wwmp 2651 38 longer long JJR cord-015306-us58wwmp 2651 39 than than IN cord-015306-us58wwmp 2651 40 in in IN cord-015306-us58wwmp 2651 41 our -PRON- PRP$ cord-015306-us58wwmp 2651 42 case case NN cord-015306-us58wwmp 2651 43 . . . cord-015306-us58wwmp 2652 1 Objective objective JJ cord-015306-us58wwmp 2652 2 , , , cord-015306-us58wwmp 2652 3 Methods Methods NNPS cord-015306-us58wwmp 2652 4 and and CC cord-015306-us58wwmp 2652 5 Results result NNS cord-015306-us58wwmp 2652 6 : : : cord-015306-us58wwmp 2653 1 A a DT cord-015306-us58wwmp 2653 2 8-year 8-year JJ cord-015306-us58wwmp 2653 3 - - HYPH cord-015306-us58wwmp 2653 4 old old JJ cord-015306-us58wwmp 2653 5 girl girl NN cord-015306-us58wwmp 2653 6 , , , cord-015306-us58wwmp 2653 7 affected affect VBN cord-015306-us58wwmp 2653 8 by by IN cord-015306-us58wwmp 2653 9 b b NN cord-015306-us58wwmp 2653 10 thalassemia thalassemia NN cord-015306-us58wwmp 2653 11 major major NN cord-015306-us58wwmp 2653 12 , , , cord-015306-us58wwmp 2653 13 was be VBD cord-015306-us58wwmp 2653 14 admitted admit VBN cord-015306-us58wwmp 2653 15 for for IN cord-015306-us58wwmp 2653 16 proteinuria proteinuria NN cord-015306-us58wwmp 2653 17 detected detect VBN cord-015306-us58wwmp 2653 18 at at IN cord-015306-us58wwmp 2653 19 the the DT cord-015306-us58wwmp 2653 20 emergency emergency NN cord-015306-us58wwmp 2653 21 unit unit NN cord-015306-us58wwmp 2653 22 . . . cord-015306-us58wwmp 2654 1 Fever fever NN cord-015306-us58wwmp 2654 2 , , , cord-015306-us58wwmp 2654 3 hyporexia hyporexia NN cord-015306-us58wwmp 2654 4 and and CC cord-015306-us58wwmp 2654 5 diarrhea diarrhea NN cord-015306-us58wwmp 2654 6 had have VBD cord-015306-us58wwmp 2654 7 been be VBN cord-015306-us58wwmp 2654 8 present present JJ cord-015306-us58wwmp 2654 9 in in IN cord-015306-us58wwmp 2654 10 the the DT cord-015306-us58wwmp 2654 11 last last JJ cord-015306-us58wwmp 2654 12 three three CD cord-015306-us58wwmp 2654 13 days day NNS cord-015306-us58wwmp 2654 14 . . . cord-015306-us58wwmp 2655 1 On on IN cord-015306-us58wwmp 2655 2 physical physical JJ cord-015306-us58wwmp 2655 3 examination examination NN cord-015306-us58wwmp 2655 4 she -PRON- PRP cord-015306-us58wwmp 2655 5 presented present VBD cord-015306-us58wwmp 2655 6 with with IN cord-015306-us58wwmp 2655 7 decreased decreased JJ cord-015306-us58wwmp 2655 8 skin skin NN cord-015306-us58wwmp 2655 9 turgor turgor NN cord-015306-us58wwmp 2655 10 and and CC cord-015306-us58wwmp 2655 11 hypertension hypertension NN cord-015306-us58wwmp 2655 12 . . . cord-015306-us58wwmp 2656 1 Laboratory laboratory NN cord-015306-us58wwmp 2656 2 examinations examination NNS cord-015306-us58wwmp 2656 3 showed show VBD cord-015306-us58wwmp 2656 4 : : : cord-015306-us58wwmp 2656 5 hyponatremia hyponatremia NN cord-015306-us58wwmp 2656 6 ( ( -LRB- cord-015306-us58wwmp 2656 7 124 124 CD cord-015306-us58wwmp 2656 8 mEq mEq NNS cord-015306-us58wwmp 2656 9 / / SYM cord-015306-us58wwmp 2656 10 l l NNP cord-015306-us58wwmp 2656 11 ) ) -RRB- cord-015306-us58wwmp 2656 12 , , , cord-015306-us58wwmp 2656 13 hypokalaemia hypokalaemia NNP cord-015306-us58wwmp 2656 14 ( ( -LRB- cord-015306-us58wwmp 2656 15 2.9 2.9 CD cord-015306-us58wwmp 2656 16 mEq mEq NNS cord-015306-us58wwmp 2656 17 / / SYM cord-015306-us58wwmp 2656 18 l l NNP cord-015306-us58wwmp 2656 19 ) ) -RRB- cord-015306-us58wwmp 2656 20 , , , cord-015306-us58wwmp 2656 21 hypophosphatemia hypophosphatemia NNP cord-015306-us58wwmp 2656 22 ( ( -LRB- cord-015306-us58wwmp 2656 23 1.1 1.1 CD cord-015306-us58wwmp 2656 24 mg mg NNP cord-015306-us58wwmp 2656 25 / / SYM cord-015306-us58wwmp 2656 26 dl dl NNP cord-015306-us58wwmp 2656 27 ) ) -RRB- cord-015306-us58wwmp 2656 28 , , , cord-015306-us58wwmp 2656 29 hyperazotemia hyperazotemia NNP cord-015306-us58wwmp 2656 30 ( ( -LRB- cord-015306-us58wwmp 2656 31 60 60 CD cord-015306-us58wwmp 2656 32 mg mg NNP cord-015306-us58wwmp 2656 33 / / SYM cord-015306-us58wwmp 2656 34 dl dl NNP cord-015306-us58wwmp 2656 35 ) ) -RRB- cord-015306-us58wwmp 2656 36 , , , cord-015306-us58wwmp 2656 37 reduced reduce VBN cord-015306-us58wwmp 2656 38 creatinine creatinine NN cord-015306-us58wwmp 2656 39 clearance clearance NN cord-015306-us58wwmp 2656 40 ( ( -LRB- cord-015306-us58wwmp 2656 41 CrCl CrCl NNP cord-015306-us58wwmp 2656 42 = = SYM cord-015306-us58wwmp 2656 43 68 68 CD cord-015306-us58wwmp 2656 44 ml ml NN cord-015306-us58wwmp 2656 45 / / SYM cord-015306-us58wwmp 2656 46 min/1.73 min/1.73 JJ cord-015306-us58wwmp 2656 47 m m CD cord-015306-us58wwmp 2656 48 2 2 CD cord-015306-us58wwmp 2656 49 ) ) -RRB- cord-015306-us58wwmp 2656 50 and and CC cord-015306-us58wwmp 2656 51 metabolic metabolic JJ cord-015306-us58wwmp 2656 52 acidosis acidosis NN cord-015306-us58wwmp 2656 53 ( ( -LRB- cord-015306-us58wwmp 2656 54 HCO HCO NNP cord-015306-us58wwmp 2656 55 3 3 CD cord-015306-us58wwmp 2656 56 -12.8 -12.8 NNP cord-015306-us58wwmp 2656 57 mmol mmol NN cord-015306-us58wwmp 2656 58 / / SYM cord-015306-us58wwmp 2656 59 l l NN cord-015306-us58wwmp 2656 60 ) ) -RRB- cord-015306-us58wwmp 2656 61 . . . cord-015306-us58wwmp 2657 1 Urine urine NN cord-015306-us58wwmp 2657 2 analysis analysis NN cord-015306-us58wwmp 2657 3 revealed reveal VBD cord-015306-us58wwmp 2657 4 : : : cord-015306-us58wwmp 2657 5 proteinuria proteinuria NN cord-015306-us58wwmp 2657 6 , , , cord-015306-us58wwmp 2657 7 glycosuria glycosuria NNP cord-015306-us58wwmp 2657 8 , , , cord-015306-us58wwmp 2657 9 hypercalciuria hypercalciuria NNP cord-015306-us58wwmp 2657 10 , , , cord-015306-us58wwmp 2657 11 hyperuricuria hyperuricuria NNP cord-015306-us58wwmp 2657 12 , , , cord-015306-us58wwmp 2657 13 hyperphosphaturia hyperphosphaturia NNP cord-015306-us58wwmp 2657 14 and and CC cord-015306-us58wwmp 2657 15 aminoaciduria aminoaciduria NNP cord-015306-us58wwmp 2657 16 . . . cord-015306-us58wwmp 2658 1 She -PRON- PRP cord-015306-us58wwmp 2658 2 had have VBD cord-015306-us58wwmp 2658 3 been be VBN cord-015306-us58wwmp 2658 4 under under IN cord-015306-us58wwmp 2658 5 treatment treatment NN cord-015306-us58wwmp 2658 6 for for IN cord-015306-us58wwmp 2658 7 five five CD cord-015306-us58wwmp 2658 8 years year NNS cord-015306-us58wwmp 2658 9 with with IN cord-015306-us58wwmp 2658 10 Deferasirox Deferasirox NNP cord-015306-us58wwmp 2658 11 ( ( -LRB- cord-015306-us58wwmp 2658 12 DFX DFX NNP cord-015306-us58wwmp 2658 13 ) ) -RRB- cord-015306-us58wwmp 2658 14 26 26 CD cord-015306-us58wwmp 2658 15 mg mg NNP cord-015306-us58wwmp 2658 16 / / SYM cord-015306-us58wwmp 2658 17 kg kg NNP cord-015306-us58wwmp 2658 18 / / SYM cord-015306-us58wwmp 2658 19 die die VBP cord-015306-us58wwmp 2658 20 . . . cord-015306-us58wwmp 2659 1 We -PRON- PRP cord-015306-us58wwmp 2659 2 stopped stop VBD cord-015306-us58wwmp 2659 3 DFX DFX NNP cord-015306-us58wwmp 2659 4 and and CC cord-015306-us58wwmp 2659 5 gave give VBD cord-015306-us58wwmp 2659 6 supplementation supplementation NN cord-015306-us58wwmp 2659 7 of of IN cord-015306-us58wwmp 2659 8 potassium potassium NN cord-015306-us58wwmp 2659 9 , , , cord-015306-us58wwmp 2659 10 phosphate phosphate NN cord-015306-us58wwmp 2659 11 , , , cord-015306-us58wwmp 2659 12 sodium sodium NN cord-015306-us58wwmp 2659 13 bicarbonate bicarbonate NN cord-015306-us58wwmp 2659 14 and and CC cord-015306-us58wwmp 2659 15 sodium sodium NN cord-015306-us58wwmp 2659 16 chloride chloride NN cord-015306-us58wwmp 2659 17 with with IN cord-015306-us58wwmp 2659 18 electrolyte electrolyte NN cord-015306-us58wwmp 2659 19 and and CC cord-015306-us58wwmp 2659 20 renal renal JJ cord-015306-us58wwmp 2659 21 function function NN cord-015306-us58wwmp 2659 22 ( ( -LRB- cord-015306-us58wwmp 2659 23 CrCl CrCl NNP cord-015306-us58wwmp 2659 24 130 130 CD cord-015306-us58wwmp 2659 25 ml ml XX cord-015306-us58wwmp 2659 26 / / SYM cord-015306-us58wwmp 2659 27 min/1.73 min/1.73 JJ cord-015306-us58wwmp 2659 28 m m CD cord-015306-us58wwmp 2659 29 2 2 CD cord-015306-us58wwmp 2659 30 ) ) -RRB- cord-015306-us58wwmp 2659 31 normalization normalization NN cord-015306-us58wwmp 2659 32 in in IN cord-015306-us58wwmp 2659 33 6 6 CD cord-015306-us58wwmp 2659 34 days day NNS cord-015306-us58wwmp 2659 35 . . . cord-015306-us58wwmp 2660 1 After after IN cord-015306-us58wwmp 2660 2 one one CD cord-015306-us58wwmp 2660 3 month month NN cord-015306-us58wwmp 2660 4 only only RB cord-015306-us58wwmp 2660 5 minimal minimal JJ cord-015306-us58wwmp 2660 6 proteinuria proteinuria NN cord-015306-us58wwmp 2660 7 persisted persist VBD cord-015306-us58wwmp 2660 8 . . . cord-015306-us58wwmp 2661 1 Conclusion conclusion NN cord-015306-us58wwmp 2661 2 : : : cord-015306-us58wwmp 2662 1 In in IN cord-015306-us58wwmp 2662 2 so so RB cord-015306-us58wwmp 2662 3 far far RB cord-015306-us58wwmp 2662 4 a a DT cord-015306-us58wwmp 2662 5 Fanconi Fanconi NNP cord-015306-us58wwmp 2662 6 Syndrome Syndrome NNP cord-015306-us58wwmp 2662 7 ( ( -LRB- cord-015306-us58wwmp 2662 8 FS FS NNP cord-015306-us58wwmp 2662 9 ) ) -RRB- cord-015306-us58wwmp 2662 10 has have VBZ cord-015306-us58wwmp 2662 11 been be VBN cord-015306-us58wwmp 2662 12 reported report VBN cord-015306-us58wwmp 2662 13 in in IN cord-015306-us58wwmp 2662 14 11 11 CD cord-015306-us58wwmp 2662 15 patients patient NNS cord-015306-us58wwmp 2662 16 ( ( -LRB- cord-015306-us58wwmp 2662 17 6 6 CD cord-015306-us58wwmp 2662 18 children child NNS cord-015306-us58wwmp 2662 19 ) ) -RRB- cord-015306-us58wwmp 2662 20 , , , cord-015306-us58wwmp 2662 21 while while IN cord-015306-us58wwmp 2662 22 mild mild JJ cord-015306-us58wwmp 2662 23 renal renal JJ cord-015306-us58wwmp 2662 24 insufficiency insufficiency NN cord-015306-us58wwmp 2662 25 ( ( -LRB- cord-015306-us58wwmp 2662 26 RI RI NNP cord-015306-us58wwmp 2662 27 ) ) -RRB- cord-015306-us58wwmp 2662 28 has have VBZ cord-015306-us58wwmp 2662 29 been be VBN cord-015306-us58wwmp 2662 30 documented document VBN cord-015306-us58wwmp 2662 31 only only RB cord-015306-us58wwmp 2662 32 in in IN cord-015306-us58wwmp 2662 33 2 2 CD cord-015306-us58wwmp 2662 34 children child NNS cord-015306-us58wwmp 2662 35 . . . cord-015306-us58wwmp 2663 1 In in IN cord-015306-us58wwmp 2663 2 our -PRON- PRP$ cord-015306-us58wwmp 2663 3 case case NN cord-015306-us58wwmp 2663 4 dehydration dehydration NN cord-015306-us58wwmp 2663 5 seems seem VBZ cord-015306-us58wwmp 2663 6 to to TO cord-015306-us58wwmp 2663 7 be be VB cord-015306-us58wwmp 2663 8 responsible responsible JJ cord-015306-us58wwmp 2663 9 for for IN cord-015306-us58wwmp 2663 10 the the DT cord-015306-us58wwmp 2663 11 RI RI NNP cord-015306-us58wwmp 2663 12 , , , cord-015306-us58wwmp 2663 13 while while IN cord-015306-us58wwmp 2663 14 an an DT cord-015306-us58wwmp 2663 15 interstitial interstitial JJ cord-015306-us58wwmp 2663 16 nephritis nephritis NN cord-015306-us58wwmp 2663 17 can can MD cord-015306-us58wwmp 2663 18 not not RB cord-015306-us58wwmp 2663 19 be be VB cord-015306-us58wwmp 2663 20 excluded exclude VBN cord-015306-us58wwmp 2663 21 . . . cord-015306-us58wwmp 2664 1 Close close JJ cord-015306-us58wwmp 2664 2 monitoring monitoring NN cord-015306-us58wwmp 2664 3 of of IN cord-015306-us58wwmp 2664 4 renal renal JJ cord-015306-us58wwmp 2664 5 function function NN cord-015306-us58wwmp 2664 6 should should MD cord-015306-us58wwmp 2664 7 be be VB cord-015306-us58wwmp 2664 8 done do VBN cord-015306-us58wwmp 2664 9 in in IN cord-015306-us58wwmp 2664 10 children child NNS cord-015306-us58wwmp 2664 11 on on IN cord-015306-us58wwmp 2664 12 DFX DFX NNP cord-015306-us58wwmp 2664 13 . . . cord-015306-us58wwmp 2665 1 Objective objective NN cord-015306-us58wwmp 2665 2 : : : cord-015306-us58wwmp 2666 1 To to TO cord-015306-us58wwmp 2666 2 test test VB cord-015306-us58wwmp 2666 3 the the DT cord-015306-us58wwmp 2666 4 hypothesis hypothesis NN cord-015306-us58wwmp 2666 5 that that WDT cord-015306-us58wwmp 2666 6 neutrophil neutrophil VBZ cord-015306-us58wwmp 2666 7 gelatinase gelatinase NN cord-015306-us58wwmp 2666 8 - - HYPH cord-015306-us58wwmp 2666 9 associated associate VBN cord-015306-us58wwmp 2666 10 lipocalin lipocalin NNP cord-015306-us58wwmp 2666 11 ( ( -LRB- cord-015306-us58wwmp 2666 12 NGAL NGAL NNP cord-015306-us58wwmp 2666 13 ) ) -RRB- cord-015306-us58wwmp 2666 14 and and CC cord-015306-us58wwmp 2666 15 interleukin-18 interleukin-18 NN cord-015306-us58wwmp 2666 16 ( ( -LRB- cord-015306-us58wwmp 2666 17 IL-18 IL-18 NNP cord-015306-us58wwmp 2666 18 ) ) -RRB- cord-015306-us58wwmp 2666 19 are be VBP cord-015306-us58wwmp 2666 20 early early JJ cord-015306-us58wwmp 2666 21 biomarkers biomarker NNS cord-015306-us58wwmp 2666 22 for for IN cord-015306-us58wwmp 2666 23 AKI AKI NNP cord-015306-us58wwmp 2666 24 in in IN cord-015306-us58wwmp 2666 25 critically critically RB cord-015306-us58wwmp 2666 26 ill ill JJ cord-015306-us58wwmp 2666 27 patients patient NNS cord-015306-us58wwmp 2666 28 and and CC cord-015306-us58wwmp 2666 29 evaluate evaluate VB cord-015306-us58wwmp 2666 30 the the DT cord-015306-us58wwmp 2666 31 predictive predictive JJ cord-015306-us58wwmp 2666 32 value value NN cord-015306-us58wwmp 2666 33 of of IN cord-015306-us58wwmp 2666 34 them -PRON- PRP cord-015306-us58wwmp 2666 35 in in IN cord-015306-us58wwmp 2666 36 patients patient NNS cord-015306-us58wwmp 2666 37 with with IN cord-015306-us58wwmp 2666 38 established establish VBN cord-015306-us58wwmp 2666 39 AKI AKI NNP cord-015306-us58wwmp 2666 40 at at IN cord-015306-us58wwmp 2666 41 inception inception NN cord-015306-us58wwmp 2666 42 of of IN cord-015306-us58wwmp 2666 43 CRRT CRRT NNP cord-015306-us58wwmp 2666 44 . . . cord-015306-us58wwmp 2667 1 Methods method NNS cord-015306-us58wwmp 2667 2 : : : cord-015306-us58wwmp 2667 3 Children child NNS cord-015306-us58wwmp 2667 4 from from IN cord-015306-us58wwmp 2667 5 PICU PICU NNP cord-015306-us58wwmp 2667 6 and and CC cord-015306-us58wwmp 2667 7 health health NN cord-015306-us58wwmp 2667 8 examination examination NN cord-015306-us58wwmp 2667 9 center center NN cord-015306-us58wwmp 2667 10 in in IN cord-015306-us58wwmp 2667 11 Guangzhou Guangzhou NNP cord-015306-us58wwmp 2667 12 Women Women NNP cord-015306-us58wwmp 2667 13 's 's POS cord-015306-us58wwmp 2667 14 and and CC cord-015306-us58wwmp 2667 15 Children Children NNP cord-015306-us58wwmp 2667 16 's 's POS cord-015306-us58wwmp 2667 17 Medical Medical NNP cord-015306-us58wwmp 2667 18 Center Center NNP cord-015306-us58wwmp 2667 19 were be VBD cord-015306-us58wwmp 2667 20 divided divide VBN cord-015306-us58wwmp 2667 21 into into IN cord-015306-us58wwmp 2667 22 four four CD cord-015306-us58wwmp 2667 23 groups group NNS cord-015306-us58wwmp 2667 24 : : : cord-015306-us58wwmp 2667 25 critically critically RB cord-015306-us58wwmp 2667 26 ill ill JJ cord-015306-us58wwmp 2667 27 patients patient NNS cord-015306-us58wwmp 2667 28 with with IN cord-015306-us58wwmp 2667 29 AKI AKI NNP cord-015306-us58wwmp 2667 30 recevied recevie VBD cord-015306-us58wwmp 2667 31 CRRT CRRT NNP cord-015306-us58wwmp 2667 32 group group NN cord-015306-us58wwmp 2667 33 ( ( -LRB- cord-015306-us58wwmp 2667 34 group1 group1 NNP cord-015306-us58wwmp 2667 35 ) ) -RRB- cord-015306-us58wwmp 2667 36 , , , cord-015306-us58wwmp 2667 37 critically critically RB cord-015306-us58wwmp 2667 38 ill ill JJ cord-015306-us58wwmp 2667 39 patients patient NNS cord-015306-us58wwmp 2667 40 with with IN cord-015306-us58wwmp 2667 41 non non JJ cord-015306-us58wwmp 2667 42 - - JJ cord-015306-us58wwmp 2667 43 AKI AKI NNP cord-015306-us58wwmp 2667 44 recevied recevie VBD cord-015306-us58wwmp 2667 45 CRRT CRRT NNP cord-015306-us58wwmp 2667 46 group(group2 group(group2 NNP cord-015306-us58wwmp 2667 47 ) ) -RRB- cord-015306-us58wwmp 2667 48 , , , cord-015306-us58wwmp 2667 49 critically critically RB cord-015306-us58wwmp 2667 50 ill ill JJ cord-015306-us58wwmp 2667 51 patients patient NNS cord-015306-us58wwmp 2667 52 with with IN cord-015306-us58wwmp 2667 53 AKI AKI NNP cord-015306-us58wwmp 2667 54 do do VBP cord-015306-us58wwmp 2667 55 n't not RB cord-015306-us58wwmp 2667 56 recevie recevie VB cord-015306-us58wwmp 2667 57 CRRT CRRT NNP cord-015306-us58wwmp 2667 58 group group NN cord-015306-us58wwmp 2667 59 ( ( -LRB- cord-015306-us58wwmp 2667 60 group group NN cord-015306-us58wwmp 2667 61 3),healthy 3),healthy CD cord-015306-us58wwmp 2667 62 control control NNP cord-015306-us58wwmp 2667 63 group group NNP cord-015306-us58wwmp 2667 64 ( ( -LRB- cord-015306-us58wwmp 2667 65 group4 group4 NNP cord-015306-us58wwmp 2667 66 ) ) -RRB- cord-015306-us58wwmp 2667 67 . . . cord-015306-us58wwmp 2668 1 1.5 1.5 CD cord-015306-us58wwmp 2668 2 mL ml NN cord-015306-us58wwmp 2668 3 venous venous JJ cord-015306-us58wwmp 2668 4 blood blood NN cord-015306-us58wwmp 2668 5 and and CC cord-015306-us58wwmp 2668 6 Urine urine NN cord-015306-us58wwmp 2668 7 specimens specimen NNS cord-015306-us58wwmp 2668 8 were be VBD cord-015306-us58wwmp 2668 9 collected collect VBN cord-015306-us58wwmp 2668 10 and and CC cord-015306-us58wwmp 2668 11 was be VBD cord-015306-us58wwmp 2668 12 kept keep VBN cord-015306-us58wwmp 2668 13 under under IN cord-015306-us58wwmp 2668 14 -70 -70 NN cord-015306-us58wwmp 2668 15 ° ° NN cord-015306-us58wwmp 2668 16 C.from C.from NNP cord-015306-us58wwmp 2669 1 each each DT cord-015306-us58wwmp 2669 2 patient patient NN cord-015306-us58wwmp 2669 3 in in IN cord-015306-us58wwmp 2669 4 PICU PICU NNP cord-015306-us58wwmp 2669 5 untill untill NNP cord-015306-us58wwmp 2669 6 they -PRON- PRP cord-015306-us58wwmp 2669 7 were be VBD cord-015306-us58wwmp 2669 8 discharged discharge VBN cord-015306-us58wwmp 2669 9 , , , cord-015306-us58wwmp 2669 10 transferred transfer VBN cord-015306-us58wwmp 2669 11 or or CC cord-015306-us58wwmp 2669 12 die die VB cord-015306-us58wwmp 2669 13 . . . cord-015306-us58wwmp 2670 1 serum serum NN cord-015306-us58wwmp 2670 2 creatinine creatinine NN cord-015306-us58wwmp 2670 3 ( ( -LRB- cord-015306-us58wwmp 2670 4 Scr Scr NNP cord-015306-us58wwmp 2670 5 ) ) -RRB- cord-015306-us58wwmp 2670 6 and and CC cord-015306-us58wwmp 2670 7 urine urine NN cord-015306-us58wwmp 2670 8 NGAL NGAL NNP cord-015306-us58wwmp 2670 9 and and CC cord-015306-us58wwmp 2670 10 urine urine NN cord-015306-us58wwmp 2670 11 IL-18 IL-18 NNP cord-015306-us58wwmp 2670 12 were be VBD cord-015306-us58wwmp 2670 13 analyzed analyze VBN cord-015306-us58wwmp 2670 14 . . . cord-015306-us58wwmp 2671 1 Results result NNS cord-015306-us58wwmp 2671 2 : : : cord-015306-us58wwmp 2672 1 Compared compare VBN cord-015306-us58wwmp 2672 2 with with IN cord-015306-us58wwmp 2672 3 group2 group2 NN cord-015306-us58wwmp 2672 4 and and CC cord-015306-us58wwmp 2672 5 group4 group4 NN cord-015306-us58wwmp 2672 6 , , , cord-015306-us58wwmp 2672 7 the the DT cord-015306-us58wwmp 2672 8 urine urine NN cord-015306-us58wwmp 2672 9 NGAL NGAL NNP cord-015306-us58wwmp 2672 10 and and CC cord-015306-us58wwmp 2672 11 urine urine NN cord-015306-us58wwmp 2672 12 IL-18 IL-18 NNP cord-015306-us58wwmp 2672 13 increases increase VBZ cord-015306-us58wwmp 2672 14 obviously obviously RB cord-015306-us58wwmp 2672 15 in in IN cord-015306-us58wwmp 2672 16 group1 group1 NN cord-015306-us58wwmp 2672 17 and and CC cord-015306-us58wwmp 2672 18 group3 group3 NNP cord-015306-us58wwmp 2672 19 ( ( -LRB- cord-015306-us58wwmp 2672 20 P<0.05 P<0.05 NNS cord-015306-us58wwmp 2672 21 ) ) -RRB- cord-015306-us58wwmp 2672 22 . . . cord-015306-us58wwmp 2673 1 There there EX cord-015306-us58wwmp 2673 2 is be VBZ cord-015306-us58wwmp 2673 3 no no DT cord-015306-us58wwmp 2673 4 significance significance NN cord-015306-us58wwmp 2673 5 of of IN cord-015306-us58wwmp 2673 6 urine urine NN cord-015306-us58wwmp 2673 7 NGAL NGAL NNP cord-015306-us58wwmp 2673 8 and and CC cord-015306-us58wwmp 2673 9 urine urine NN cord-015306-us58wwmp 2673 10 IL-18 IL-18 NNP cord-015306-us58wwmp 2673 11 between between IN cord-015306-us58wwmp 2673 12 group2 group2 NN cord-015306-us58wwmp 2673 13 and and CC cord-015306-us58wwmp 2673 14 group group NN cord-015306-us58wwmp 2673 15 4.(P 4.(p CD cord-015306-us58wwmp 2674 1 > > XX cord-015306-us58wwmp 2675 1 0.05).The 0.05).the LS cord-015306-us58wwmp 2675 2 concentration concentration NN cord-015306-us58wwmp 2675 3 of of IN cord-015306-us58wwmp 2675 4 urine urine NN cord-015306-us58wwmp 2675 5 NGAL NGAL NNP cord-015306-us58wwmp 2675 6 increased increase VBD cord-015306-us58wwmp 2675 7 more more JJR cord-015306-us58wwmp 2675 8 than10 than10 NNS cord-015306-us58wwmp 2675 9 times time NNS cord-015306-us58wwmp 2675 10 obviously obviously RB cord-015306-us58wwmp 2675 11 2 2 CD cord-015306-us58wwmp 2675 12 days day NNS cord-015306-us58wwmp 2675 13 before before IN cord-015306-us58wwmp 2675 14 diagnosed diagnose VBN cord-015306-us58wwmp 2675 15 of of IN cord-015306-us58wwmp 2675 16 AKI AKI NNP cord-015306-us58wwmp 2675 17 under under IN cord-015306-us58wwmp 2675 18 the the DT cord-015306-us58wwmp 2675 19 AKIN akin NN cord-015306-us58wwmp 2675 20 standard standard NN cord-015306-us58wwmp 2675 21 with with IN cord-015306-us58wwmp 2675 22 AUC AUC NNP cord-015306-us58wwmp 2675 23 0.841(P 0.841(p CD cord-015306-us58wwmp 2675 24 < < XX cord-015306-us58wwmp 2675 25 0.05 0.05 CD cord-015306-us58wwmp 2675 26 ) ) -RRB- cord-015306-us58wwmp 2675 27 , , , cord-015306-us58wwmp 2675 28 and and CC cord-015306-us58wwmp 2675 29 the the DT cord-015306-us58wwmp 2675 30 concentration concentration NN cord-015306-us58wwmp 2675 31 of of IN cord-015306-us58wwmp 2675 32 urine urine NN cord-015306-us58wwmp 2675 33 IL-18 IL-18 NNP cord-015306-us58wwmp 2675 34 increased increase VBD cord-015306-us58wwmp 2675 35 more more JJR cord-015306-us58wwmp 2675 36 than than IN cord-015306-us58wwmp 2675 37 5 5 CD cord-015306-us58wwmp 2675 38 times time NNS cord-015306-us58wwmp 2675 39 2 2 CD cord-015306-us58wwmp 2675 40 day day NN cord-015306-us58wwmp 2675 41 before before IN cord-015306-us58wwmp 2675 42 AKI AKI NNP cord-015306-us58wwmp 2675 43 with with IN cord-015306-us58wwmp 2675 44 AUC AUC NNP cord-015306-us58wwmp 2675 45 0.808(P 0.808(p CD cord-015306-us58wwmp 2675 46 < < XX cord-015306-us58wwmp 2675 47 0.05 0.05 CD cord-015306-us58wwmp 2675 48 ) ) -RRB- cord-015306-us58wwmp 2675 49 . . . cord-015306-us58wwmp 2676 1 The the DT cord-015306-us58wwmp 2676 2 AUC AUC NNP cord-015306-us58wwmp 2676 3 was be VBD cord-015306-us58wwmp 2676 4 0.943(P 0.943(p CD cord-015306-us58wwmp 2676 5 < < XX cord-015306-us58wwmp 2676 6 0.01 0.01 CD cord-015306-us58wwmp 2676 7 ) ) -RRB- cord-015306-us58wwmp 2676 8 when when WRB cord-015306-us58wwmp 2676 9 they -PRON- PRP cord-015306-us58wwmp 2676 10 were be VBD cord-015306-us58wwmp 2676 11 combined combine VBN cord-015306-us58wwmp 2676 12 . . . cord-015306-us58wwmp 2677 1 The the DT cord-015306-us58wwmp 2677 2 level level NN cord-015306-us58wwmp 2677 3 of of IN cord-015306-us58wwmp 2677 4 urine urine NN cord-015306-us58wwmp 2677 5 NGALand ngaland CC cord-015306-us58wwmp 2677 6 IL-18 IL-18 NNP cord-015306-us58wwmp 2677 7 at at IN cord-015306-us58wwmp 2677 8 initiation initiation NN cord-015306-us58wwmp 2677 9 of of IN cord-015306-us58wwmp 2677 10 RRT RRT NNP cord-015306-us58wwmp 2677 11 were be VBD cord-015306-us58wwmp 2677 12 higher high JJR cord-015306-us58wwmp 2677 13 in in IN cord-015306-us58wwmp 2677 14 in in IN cord-015306-us58wwmp 2677 15 non non JJ cord-015306-us58wwmp 2677 16 - - NNS cord-015306-us58wwmp 2677 17 survivors survivor NNS cord-015306-us58wwmp 2677 18 compared compare VBN cord-015306-us58wwmp 2677 19 to to IN cord-015306-us58wwmp 2677 20 survivors survivor NNS cord-015306-us58wwmp 2677 21 . . . cord-015306-us58wwmp 2678 1 Conclusion conclusion NN cord-015306-us58wwmp 2678 2 : : : cord-015306-us58wwmp 2679 1 Urine Urine NNP cord-015306-us58wwmp 2679 2 NGAL NGAL NNP cord-015306-us58wwmp 2679 3 and and CC cord-015306-us58wwmp 2679 4 urine urine NN cord-015306-us58wwmp 2679 5 IL-18 IL-18 NNP cord-015306-us58wwmp 2679 6 are be VBP cord-015306-us58wwmp 2679 7 useful useful JJ cord-015306-us58wwmp 2679 8 indicators indicator NNS cord-015306-us58wwmp 2679 9 to to TO cord-015306-us58wwmp 2679 10 predict predict VB cord-015306-us58wwmp 2679 11 and and CC cord-015306-us58wwmp 2679 12 early early RB cord-015306-us58wwmp 2679 13 diagnose diagnose VB cord-015306-us58wwmp 2679 14 AKI AKI NNP cord-015306-us58wwmp 2679 15 . . . cord-015306-us58wwmp 2680 1 The the DT cord-015306-us58wwmp 2680 2 level level NN cord-015306-us58wwmp 2680 3 of of IN cord-015306-us58wwmp 2680 4 urine urine NN cord-015306-us58wwmp 2680 5 NGAL NGAL NNP cord-015306-us58wwmp 2680 6 and and CC cord-015306-us58wwmp 2680 7 IL-18 IL-18 NNP cord-015306-us58wwmp 2680 8 at at IN cord-015306-us58wwmp 2680 9 initiation initiation NN cord-015306-us58wwmp 2680 10 of of IN cord-015306-us58wwmp 2680 11 RRT.were rrt.were JJ cord-015306-us58wwmp 2680 12 negative negative JJ cord-015306-us58wwmp 2680 13 correlation correlation NN cord-015306-us58wwmp 2680 14 with with IN cord-015306-us58wwmp 2680 15 the the DT cord-015306-us58wwmp 2680 16 outcome outcome NN cord-015306-us58wwmp 2680 17 of of IN cord-015306-us58wwmp 2680 18 renal renal JJ cord-015306-us58wwmp 2680 19 prognosis prognosis NN cord-015306-us58wwmp 2680 20 and and CC cord-015306-us58wwmp 2680 21 survival survival NN cord-015306-us58wwmp 2680 22 rate rate NN cord-015306-us58wwmp 2680 23 . . . cord-015306-us58wwmp 2681 1 Objective objective NN cord-015306-us58wwmp 2681 2 : : : cord-015306-us58wwmp 2682 1 The the DT cord-015306-us58wwmp 2682 2 aim aim NN cord-015306-us58wwmp 2682 3 of of IN cord-015306-us58wwmp 2682 4 this this DT cord-015306-us58wwmp 2682 5 study study NN cord-015306-us58wwmp 2682 6 was be VBD cord-015306-us58wwmp 2682 7 to to TO cord-015306-us58wwmp 2682 8 evaluate evaluate VB cord-015306-us58wwmp 2682 9 the the DT cord-015306-us58wwmp 2682 10 rate rate NN cord-015306-us58wwmp 2682 11 of of IN cord-015306-us58wwmp 2682 12 early early JJ cord-015306-us58wwmp 2682 13 kidney kidney NN cord-015306-us58wwmp 2682 14 injury injury NN cord-015306-us58wwmp 2682 15 in in IN cord-015306-us58wwmp 2682 16 infants infant NNS cord-015306-us58wwmp 2682 17 with with IN cord-015306-us58wwmp 2682 18 congenital congenital JJ cord-015306-us58wwmp 2682 19 heart heart NN cord-015306-us58wwmp 2682 20 disease disease NN cord-015306-us58wwmp 2682 21 ( ( -LRB- cord-015306-us58wwmp 2682 22 CHD CHD NNP cord-015306-us58wwmp 2682 23 ) ) -RRB- cord-015306-us58wwmp 2682 24 . . . cord-015306-us58wwmp 2683 1 Neutrophil Neutrophil NNP cord-015306-us58wwmp 2683 2 gelatinase gelatinase NN cord-015306-us58wwmp 2683 3 associated associate VBN cord-015306-us58wwmp 2683 4 with with IN cord-015306-us58wwmp 2683 5 lipocalin lipocalin NNP cord-015306-us58wwmp 2683 6 ( ( -LRB- cord-015306-us58wwmp 2683 7 NGAL NGAL NNP cord-015306-us58wwmp 2683 8 ) ) -RRB- cord-015306-us58wwmp 2683 9 which which WDT cord-015306-us58wwmp 2683 10 can can MD cord-015306-us58wwmp 2683 11 be be VB cord-015306-us58wwmp 2683 12 measured measure VBN cord-015306-us58wwmp 2683 13 both both CC cord-015306-us58wwmp 2683 14 in in IN cord-015306-us58wwmp 2683 15 serum serum NN cord-015306-us58wwmp 2683 16 ( ( -LRB- cord-015306-us58wwmp 2683 17 sNGAL sNGAL NNP cord-015306-us58wwmp 2683 18 ) ) -RRB- cord-015306-us58wwmp 2683 19 and and CC cord-015306-us58wwmp 2683 20 in in IN cord-015306-us58wwmp 2683 21 urine urine NN cord-015306-us58wwmp 2683 22 ( ( -LRB- cord-015306-us58wwmp 2683 23 uNGAL uNGAL NNP cord-015306-us58wwmp 2683 24 ) ) -RRB- cord-015306-us58wwmp 2683 25 , , , cord-015306-us58wwmp 2683 26 is be VBZ cord-015306-us58wwmp 2683 27 at at IN cord-015306-us58wwmp 2683 28 the the DT cord-015306-us58wwmp 2683 29 moment moment NN cord-015306-us58wwmp 2683 30 the the DT cord-015306-us58wwmp 2683 31 most most RBS cord-015306-us58wwmp 2683 32 promising promising JJ cord-015306-us58wwmp 2683 33 marker marker NN cord-015306-us58wwmp 2683 34 directed direct VBN cord-015306-us58wwmp 2683 35 to to TO cord-015306-us58wwmp 2683 36 discover discover VB cord-015306-us58wwmp 2683 37 early early JJ cord-015306-us58wwmp 2683 38 kidney kidney NN cord-015306-us58wwmp 2683 39 injury injury NN cord-015306-us58wwmp 2683 40 within within IN cord-015306-us58wwmp 2683 41 the the DT cord-015306-us58wwmp 2683 42 glomeruli glomerulus NNS cord-015306-us58wwmp 2683 43 and and CC cord-015306-us58wwmp 2683 44 distal distal JJ cord-015306-us58wwmp 2683 45 and and CC cord-015306-us58wwmp 2683 46 proximal proximal JJ cord-015306-us58wwmp 2683 47 tubules tubule NNS cord-015306-us58wwmp 2683 48 . . . cord-015306-us58wwmp 2684 1 Less less RBR cord-015306-us58wwmp 2684 2 known known JJ cord-015306-us58wwmp 2684 3 is be VBZ cord-015306-us58wwmp 2684 4 cathepsine cathepsine NNP cord-015306-us58wwmp 2684 5 L L NNP cord-015306-us58wwmp 2684 6 as as IN cord-015306-us58wwmp 2684 7 a a DT cord-015306-us58wwmp 2684 8 marker marker NN cord-015306-us58wwmp 2684 9 of of IN cord-015306-us58wwmp 2684 10 tubule tubule NN cord-015306-us58wwmp 2684 11 necrosis necrosis NN cord-015306-us58wwmp 2684 12 . . . cord-015306-us58wwmp 2685 1 Methods method NNS cord-015306-us58wwmp 2685 2 : : : cord-015306-us58wwmp 2686 1 The the DT cord-015306-us58wwmp 2686 2 study study NN cord-015306-us58wwmp 2686 3 group group NN cord-015306-us58wwmp 2686 4 consisted consist VBD cord-015306-us58wwmp 2686 5 of of IN cord-015306-us58wwmp 2686 6 patients patient NNS cord-015306-us58wwmp 2686 7 ( ( -LRB- cord-015306-us58wwmp 2686 8 22 22 CD cord-015306-us58wwmp 2686 9 boys boy NNS cord-015306-us58wwmp 2686 10 and and CC cord-015306-us58wwmp 2686 11 12 12 CD cord-015306-us58wwmp 2686 12 girls girl NNS cord-015306-us58wwmp 2686 13 ) ) -RRB- cord-015306-us58wwmp 2686 14 with with IN cord-015306-us58wwmp 2686 15 congenital congenital JJ cord-015306-us58wwmp 2686 16 heart heart NN cord-015306-us58wwmp 2686 17 disease disease NN cord-015306-us58wwmp 2686 18 . . . cord-015306-us58wwmp 2687 1 All all DT cord-015306-us58wwmp 2687 2 patients patient NNS cord-015306-us58wwmp 2687 3 were be VBD cord-015306-us58wwmp 2687 4 under under IN cord-015306-us58wwmp 2687 5 3 3 CD cord-015306-us58wwmp 2687 6 years year NNS cord-015306-us58wwmp 2687 7 of of IN cord-015306-us58wwmp 2687 8 age age NN cord-015306-us58wwmp 2687 9 ( ( -LRB- cord-015306-us58wwmp 2687 10 mean mean VB cord-015306-us58wwmp 2687 11 8.2 8.2 CD cord-015306-us58wwmp 2687 12 months month NNS cord-015306-us58wwmp 2687 13 ) ) -RRB- cord-015306-us58wwmp 2687 14 . . . cord-015306-us58wwmp 2688 1 Blood blood NN cord-015306-us58wwmp 2688 2 and and CC cord-015306-us58wwmp 2688 3 urine urine NN cord-015306-us58wwmp 2688 4 samples sample NNS cord-015306-us58wwmp 2688 5 were be VBD cord-015306-us58wwmp 2688 6 obtained obtain VBN cord-015306-us58wwmp 2688 7 during during IN cord-015306-us58wwmp 2688 8 routine routine JJ cord-015306-us58wwmp 2688 9 checkups checkup NNS cord-015306-us58wwmp 2688 10 . . . cord-015306-us58wwmp 2689 1 All all DT cord-015306-us58wwmp 2689 2 patients patient NNS cord-015306-us58wwmp 2689 3 had have VBD cord-015306-us58wwmp 2689 4 normal normal JJ cord-015306-us58wwmp 2689 5 serum serum NN cord-015306-us58wwmp 2689 6 creatinine creatinine NN cord-015306-us58wwmp 2689 7 level level NN cord-015306-us58wwmp 2689 8 at at IN cord-015306-us58wwmp 2689 9 the the DT cord-015306-us58wwmp 2689 10 day day NN cord-015306-us58wwmp 2689 11 of of IN cord-015306-us58wwmp 2689 12 collecting collect VBG cord-015306-us58wwmp 2689 13 samples sample NNS cord-015306-us58wwmp 2689 14 . . . cord-015306-us58wwmp 2690 1 The the DT cord-015306-us58wwmp 2690 2 control control NN cord-015306-us58wwmp 2690 3 group group NN cord-015306-us58wwmp 2690 4 ( ( -LRB- cord-015306-us58wwmp 2690 5 n n NN cord-015306-us58wwmp 2690 6 = = SYM cord-015306-us58wwmp 2690 7 20 20 CD cord-015306-us58wwmp 2690 8 ) ) -RRB- cord-015306-us58wwmp 2690 9 was be VBD cord-015306-us58wwmp 2690 10 age age NN cord-015306-us58wwmp 2690 11 - - HYPH cord-015306-us58wwmp 2690 12 and and CC cord-015306-us58wwmp 2690 13 gender gender NN cord-015306-us58wwmp 2690 14 - - HYPH cord-015306-us58wwmp 2690 15 matched match VBN cord-015306-us58wwmp 2690 16 . . . cord-015306-us58wwmp 2691 1 Levels level NNS cord-015306-us58wwmp 2691 2 of of IN cord-015306-us58wwmp 2691 3 sNGAL sNGAL NNP cord-015306-us58wwmp 2691 4 , , , cord-015306-us58wwmp 2691 5 uNGAL uNGAL NNP cord-015306-us58wwmp 2691 6 and and CC cord-015306-us58wwmp 2691 7 cathepsine cathepsine NN cord-015306-us58wwmp 2691 8 were be VBD cord-015306-us58wwmp 2691 9 compared compare VBN cord-015306-us58wwmp 2691 10 in in IN cord-015306-us58wwmp 2691 11 whole whole JJ cord-015306-us58wwmp 2691 12 group group NN cord-015306-us58wwmp 2691 13 . . . cord-015306-us58wwmp 2692 1 The the DT cord-015306-us58wwmp 2692 2 study study NN cord-015306-us58wwmp 2692 3 group group NN cord-015306-us58wwmp 2692 4 was be VBD cord-015306-us58wwmp 2692 5 divided divide VBN cord-015306-us58wwmp 2692 6 depending depend VBG cord-015306-us58wwmp 2692 7 on on IN cord-015306-us58wwmp 2692 8 the the DT cord-015306-us58wwmp 2692 9 nature nature NN cord-015306-us58wwmp 2692 10 of of IN cord-015306-us58wwmp 2692 11 the the DT cord-015306-us58wwmp 2692 12 defect defect NN cord-015306-us58wwmp 2692 13 ( ( -LRB- cord-015306-us58wwmp 2692 14 cyanotic cyanotic JJ cord-015306-us58wwmp 2692 15 / / SYM cord-015306-us58wwmp 2692 16 acyanotic acyanotic VBN cord-015306-us58wwmp 2692 17 ) ) -RRB- cord-015306-us58wwmp 2692 18 and and CC cord-015306-us58wwmp 2692 19 the the DT cord-015306-us58wwmp 2692 20 treatment treatment NN cord-015306-us58wwmp 2692 21 ( ( -LRB- cord-015306-us58wwmp 2692 22 surgical surgical JJ cord-015306-us58wwmp 2692 23 / / SYM cord-015306-us58wwmp 2692 24 conservative conservative JJ cord-015306-us58wwmp 2692 25 treatment treatment NN cord-015306-us58wwmp 2692 26 ) ) -RRB- cord-015306-us58wwmp 2692 27 . . . cord-015306-us58wwmp 2693 1 Results result NNS cord-015306-us58wwmp 2693 2 : : : cord-015306-us58wwmp 2694 1 Chlidren Chlidren NNP cord-015306-us58wwmp 2694 2 with with IN cord-015306-us58wwmp 2694 3 congenital congenital JJ cord-015306-us58wwmp 2694 4 heart heart NN cord-015306-us58wwmp 2694 5 disease disease NN cord-015306-us58wwmp 2694 6 had have VBD cord-015306-us58wwmp 2694 7 significantly significantly RB cord-015306-us58wwmp 2694 8 higher high JJR cord-015306-us58wwmp 2694 9 concentration concentration NN cord-015306-us58wwmp 2694 10 of of IN cord-015306-us58wwmp 2694 11 sNGAL sNGAL NNP cord-015306-us58wwmp 2694 12 , , , cord-015306-us58wwmp 2694 13 uNGAL ungal JJ cord-015306-us58wwmp 2694 14 and and CC cord-015306-us58wwmp 2694 15 urine urine NN cord-015306-us58wwmp 2694 16 cathepsine cathepsine NN cord-015306-us58wwmp 2694 17 than than IN cord-015306-us58wwmp 2694 18 the the DT cord-015306-us58wwmp 2694 19 control control NN cord-015306-us58wwmp 2694 20 group group NN cord-015306-us58wwmp 2694 21 . . . cord-015306-us58wwmp 2695 1 No no DT cord-015306-us58wwmp 2695 2 significant significant JJ cord-015306-us58wwmp 2695 3 difference difference NN cord-015306-us58wwmp 2695 4 was be VBD cord-015306-us58wwmp 2695 5 observed observe VBN cord-015306-us58wwmp 2695 6 in in IN cord-015306-us58wwmp 2695 7 the the DT cord-015306-us58wwmp 2695 8 urine urine NN cord-015306-us58wwmp 2695 9 cathepsine cathepsine NN cord-015306-us58wwmp 2695 10 and and CC cord-015306-us58wwmp 2695 11 urine urine NN cord-015306-us58wwmp 2695 12 and and CC cord-015306-us58wwmp 2695 13 serum serum NN cord-015306-us58wwmp 2695 14 NGAL NGAL NNP cord-015306-us58wwmp 2695 15 level level NN cord-015306-us58wwmp 2695 16 between between IN cord-015306-us58wwmp 2695 17 patients patient NNS cord-015306-us58wwmp 2695 18 with with IN cord-015306-us58wwmp 2695 19 acyanotic acyanotic JJ cord-015306-us58wwmp 2695 20 and and CC cord-015306-us58wwmp 2695 21 cyanotic cyanotic JJ cord-015306-us58wwmp 2695 22 CHD chd NN cord-015306-us58wwmp 2695 23 . . . cord-015306-us58wwmp 2696 1 There there EX cord-015306-us58wwmp 2696 2 were be VBD cord-015306-us58wwmp 2696 3 also also RB cord-015306-us58wwmp 2696 4 no no DT cord-015306-us58wwmp 2696 5 significant significant JJ cord-015306-us58wwmp 2696 6 differences difference NNS cord-015306-us58wwmp 2696 7 in in IN cord-015306-us58wwmp 2696 8 patients patient NNS cord-015306-us58wwmp 2696 9 who who WP cord-015306-us58wwmp 2696 10 underwent undergo VBD cord-015306-us58wwmp 2696 11 surgery surgery NN cord-015306-us58wwmp 2696 12 and and CC cord-015306-us58wwmp 2696 13 on on IN cord-015306-us58wwmp 2696 14 conservative conservative JJ cord-015306-us58wwmp 2696 15 treatment treatment NN cord-015306-us58wwmp 2696 16 in in IN cord-015306-us58wwmp 2696 17 NGAL NGAL NNP cord-015306-us58wwmp 2696 18 level level NN cord-015306-us58wwmp 2696 19 ( ( -LRB- cord-015306-us58wwmp 2696 20 both both DT cord-015306-us58wwmp 2696 21 in in IN cord-015306-us58wwmp 2696 22 urine urine NN cord-015306-us58wwmp 2696 23 and and CC cord-015306-us58wwmp 2696 24 serum serum NN cord-015306-us58wwmp 2696 25 ) ) -RRB- cord-015306-us58wwmp 2696 26 . . . cord-015306-us58wwmp 2697 1 Cathepsine Cathepsine NNP cord-015306-us58wwmp 2697 2 level level NN cord-015306-us58wwmp 2697 3 was be VBD cord-015306-us58wwmp 2697 4 significantly significantly RB cord-015306-us58wwmp 2697 5 higher high JJR cord-015306-us58wwmp 2697 6 in in IN cord-015306-us58wwmp 2697 7 group group NN cord-015306-us58wwmp 2697 8 after after IN cord-015306-us58wwmp 2697 9 surgical surgical JJ cord-015306-us58wwmp 2697 10 treatment treatment NN cord-015306-us58wwmp 2697 11 . . . cord-015306-us58wwmp 2698 1 Conclusion conclusion NN cord-015306-us58wwmp 2698 2 : : : cord-015306-us58wwmp 2698 3 Patients patient NNS cord-015306-us58wwmp 2698 4 with with IN cord-015306-us58wwmp 2698 5 CHD CHD NNP cord-015306-us58wwmp 2698 6 are be VBP cord-015306-us58wwmp 2698 7 at at IN cord-015306-us58wwmp 2698 8 higher high JJR cord-015306-us58wwmp 2698 9 risk risk NN cord-015306-us58wwmp 2698 10 of of IN cord-015306-us58wwmp 2698 11 early early JJ cord-015306-us58wwmp 2698 12 kidney kidney NN cord-015306-us58wwmp 2698 13 damage damage NN cord-015306-us58wwmp 2698 14 . . . cord-015306-us58wwmp 2699 1 This this DT cord-015306-us58wwmp 2699 2 process process NN cord-015306-us58wwmp 2699 3 is be VBZ cord-015306-us58wwmp 2699 4 independent independent JJ cord-015306-us58wwmp 2699 5 on on IN cord-015306-us58wwmp 2699 6 the the DT cord-015306-us58wwmp 2699 7 etiology etiology NN cord-015306-us58wwmp 2699 8 and and CC cord-015306-us58wwmp 2699 9 nature nature NN cord-015306-us58wwmp 2699 10 of of IN cord-015306-us58wwmp 2699 11 the the DT cord-015306-us58wwmp 2699 12 defect defect NN cord-015306-us58wwmp 2699 13 . . . cord-015306-us58wwmp 2700 1 NGAL NGAL NNP cord-015306-us58wwmp 2700 2 determined determine VBD cord-015306-us58wwmp 2700 3 in in IN cord-015306-us58wwmp 2700 4 the the DT cord-015306-us58wwmp 2700 5 serum serum NN cord-015306-us58wwmp 2700 6 and and CC cord-015306-us58wwmp 2700 7 urine urine NN cord-015306-us58wwmp 2700 8 of of IN cord-015306-us58wwmp 2700 9 these these DT cord-015306-us58wwmp 2700 10 patients patient NNS cord-015306-us58wwmp 2700 11 may may MD cord-015306-us58wwmp 2700 12 be be VB cord-015306-us58wwmp 2700 13 used use VBN cord-015306-us58wwmp 2700 14 to to TO cord-015306-us58wwmp 2700 15 detect detect VB cord-015306-us58wwmp 2700 16 kidney kidney NN cord-015306-us58wwmp 2700 17 injury injury NN cord-015306-us58wwmp 2700 18 or or CC cord-015306-us58wwmp 2700 19 monitoring monitor VBG cord-015306-us58wwmp 2700 20 disease disease NN cord-015306-us58wwmp 2700 21 progression progression NN cord-015306-us58wwmp 2700 22 . . . cord-015306-us58wwmp 2701 1 Urine urine NN cord-015306-us58wwmp 2701 2 cathepsine cathepsine NN cord-015306-us58wwmp 2701 3 is be VBZ cord-015306-us58wwmp 2701 4 more more RBR cord-015306-us58wwmp 2701 5 efficient efficient JJ cord-015306-us58wwmp 2701 6 marker marker NN cord-015306-us58wwmp 2701 7 of of IN cord-015306-us58wwmp 2701 8 early early JJ cord-015306-us58wwmp 2701 9 kidney kidney NN cord-015306-us58wwmp 2701 10 injury injury NN cord-015306-us58wwmp 2701 11 in in IN cord-015306-us58wwmp 2701 12 patients patient NNS cord-015306-us58wwmp 2701 13 after after IN cord-015306-us58wwmp 2701 14 cardiac cardiac JJ cord-015306-us58wwmp 2701 15 surgery surgery NN cord-015306-us58wwmp 2701 16 . . . cord-015306-us58wwmp 2702 1 Abstract abstract JJ cord-015306-us58wwmp 2702 2 # # NN cord-015306-us58wwmp 2703 1 P p NN cord-015306-us58wwmp 2703 2 - - HYPH cord-015306-us58wwmp 2703 3 SAT318 sat318 NN cord-015306-us58wwmp 2704 1 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2704 2 expression expression NN cord-015306-us58wwmp 2704 3 in in IN cord-015306-us58wwmp 2704 4 kidney kidney NN cord-015306-us58wwmp 2704 5 mononuclear mononuclear NN cord-015306-us58wwmp 2704 6 cells cell NNS cord-015306-us58wwmp 2704 7 and and CC cord-015306-us58wwmp 2704 8 its -PRON- PRP$ cord-015306-us58wwmp 2704 9 relationship relationship NN cord-015306-us58wwmp 2704 10 with with IN cord-015306-us58wwmp 2705 1 Foxp3 foxp3 JJ cord-015306-us58wwmp 2705 2 + + CC cord-015306-us58wwmp 2706 1 Tregs Tregs NNP cord-015306-us58wwmp 2706 2 from from IN cord-015306-us58wwmp 2706 3 mice mouse NNS cord-015306-us58wwmp 2706 4 with with IN cord-015306-us58wwmp 2706 5 renal renal JJ cord-015306-us58wwmp 2706 6 ischemia ischemia NN cord-015306-us58wwmp 2706 7 reperfusion reperfusion NN cord-015306-us58wwmp 2706 8 injury injury NN cord-015306-us58wwmp 2706 9 Yamei Yamei NNP cord-015306-us58wwmp 2706 10 Wang Wang NNP cord-015306-us58wwmp 2706 11 , , , cord-015306-us58wwmp 2706 12 Yuhong Yuhong NNP cord-015306-us58wwmp 2706 13 Tao Tao NNP cord-015306-us58wwmp 2706 14 , , , cord-015306-us58wwmp 2706 15 Li Li NNP cord-015306-us58wwmp 2706 16 Ye Ye NNP cord-015306-us58wwmp 2706 17 Department Department NNP cord-015306-us58wwmp 2706 18 of of IN cord-015306-us58wwmp 2706 19 Pediatrics Pediatrics NNP cord-015306-us58wwmp 2706 20 , , , cord-015306-us58wwmp 2706 21 West West NNP cord-015306-us58wwmp 2706 22 China China NNP cord-015306-us58wwmp 2706 23 Second Second NNP cord-015306-us58wwmp 2706 24 University University NNP cord-015306-us58wwmp 2706 25 Hospital Hospital NNP cord-015306-us58wwmp 2706 26 , , , cord-015306-us58wwmp 2706 27 Chengdu Chengdu NNP cord-015306-us58wwmp 2706 28 , , , cord-015306-us58wwmp 2707 1 China China NNP cord-015306-us58wwmp 2707 2 Objective Objective NNP cord-015306-us58wwmp 2707 3 : : : cord-015306-us58wwmp 2708 1 Foxp3 foxp3 JJ cord-015306-us58wwmp 2708 2 + + CC cord-015306-us58wwmp 2709 1 Tregs Tregs NNP cord-015306-us58wwmp 2709 2 participate participate VBP cord-015306-us58wwmp 2709 3 in in IN cord-015306-us58wwmp 2709 4 the the DT cord-015306-us58wwmp 2709 5 repair repair NN cord-015306-us58wwmp 2709 6 of of IN cord-015306-us58wwmp 2709 7 renal renal JJ cord-015306-us58wwmp 2709 8 ischemia ischemia NN cord-015306-us58wwmp 2709 9 reperfusion reperfusion NN cord-015306-us58wwmp 2709 10 injury injury NN cord-015306-us58wwmp 2709 11 . . . cord-015306-us58wwmp 2710 1 T t NN cord-015306-us58wwmp 2710 2 cell cell NN cord-015306-us58wwmp 2710 3 immunoglobulin-3 immunoglobulin-3 NN cord-015306-us58wwmp 2710 4 ( ( -LRB- cord-015306-us58wwmp 2710 5 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2710 6 ) ) -RRB- cord-015306-us58wwmp 2710 7 plays play VBZ cord-015306-us58wwmp 2710 8 a a DT cord-015306-us58wwmp 2710 9 pivotal pivotal JJ cord-015306-us58wwmp 2710 10 role role NN cord-015306-us58wwmp 2710 11 in in IN cord-015306-us58wwmp 2710 12 several several JJ cord-015306-us58wwmp 2710 13 inflammatory inflammatory JJ cord-015306-us58wwmp 2710 14 diseases disease NNS cord-015306-us58wwmp 2710 15 by by IN cord-015306-us58wwmp 2710 16 modulation modulation NN cord-015306-us58wwmp 2710 17 of of IN cord-015306-us58wwmp 2711 1 Foxp3 foxp3 JJ cord-015306-us58wwmp 2711 2 + + CC cord-015306-us58wwmp 2711 3 regulatory regulatory JJ cord-015306-us58wwmp 2711 4 T T NNP cord-015306-us58wwmp 2711 5 ( ( -LRB- cord-015306-us58wwmp 2711 6 Treg Treg NNP cord-015306-us58wwmp 2711 7 ) ) -RRB- cord-015306-us58wwmp 2711 8 cells cell NNS cord-015306-us58wwmp 2711 9 . . . cord-015306-us58wwmp 2712 1 To to TO cord-015306-us58wwmp 2712 2 detect detect VB cord-015306-us58wwmp 2712 3 the the DT cord-015306-us58wwmp 2712 4 expression expression NN cord-015306-us58wwmp 2712 5 of of IN cord-015306-us58wwmp 2712 6 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2712 7 in in IN cord-015306-us58wwmp 2712 8 kidney kidney NN cord-015306-us58wwmp 2712 9 mononuclear mononuclear NN cord-015306-us58wwmp 2712 10 cells cell NNS cord-015306-us58wwmp 2712 11 ( ( -LRB- cord-015306-us58wwmp 2712 12 KMNCs kmnc NNS cord-015306-us58wwmp 2712 13 ) ) -RRB- cord-015306-us58wwmp 2712 14 from from IN cord-015306-us58wwmp 2712 15 mice mouse NNS cord-015306-us58wwmp 2712 16 with with IN cord-015306-us58wwmp 2712 17 renal renal JJ cord-015306-us58wwmp 2712 18 IRI IRI NNP cord-015306-us58wwmp 2712 19 and and CC cord-015306-us58wwmp 2712 20 analyze analyze VB cord-015306-us58wwmp 2712 21 the the DT cord-015306-us58wwmp 2712 22 relationship relationship NN cord-015306-us58wwmp 2712 23 with with IN cord-015306-us58wwmp 2713 1 Foxp3 foxp3 JJ cord-015306-us58wwmp 2713 2 + + CC cord-015306-us58wwmp 2714 1 Tregs Tregs NNP cord-015306-us58wwmp 2714 2 , , , cord-015306-us58wwmp 2714 3 to to TO cord-015306-us58wwmp 2714 4 explore explore VB cord-015306-us58wwmp 2714 5 the the DT cord-015306-us58wwmp 2714 6 role role NN cord-015306-us58wwmp 2714 7 of of IN cord-015306-us58wwmp 2714 8 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2714 9 in in IN cord-015306-us58wwmp 2714 10 repair repair NN cord-015306-us58wwmp 2714 11 of of IN cord-015306-us58wwmp 2714 12 renal renal JJ cord-015306-us58wwmp 2714 13 IRI IRI NNP cord-015306-us58wwmp 2714 14 . . . cord-015306-us58wwmp 2715 1 Methods method NNS cord-015306-us58wwmp 2715 2 : : : cord-015306-us58wwmp 2716 1 The the DT cord-015306-us58wwmp 2716 2 left left JJ cord-015306-us58wwmp 2716 3 renal renal JJ cord-015306-us58wwmp 2716 4 pedicle pedicle NN cord-015306-us58wwmp 2716 5 was be VBD cord-015306-us58wwmp 2716 6 clamped clamp VBN cord-015306-us58wwmp 2716 7 in in IN cord-015306-us58wwmp 2716 8 C57BL6 C57BL6 NNP cord-015306-us58wwmp 2716 9 mice mouse NNS cord-015306-us58wwmp 2716 10 for for IN cord-015306-us58wwmp 2716 11 45 45 CD cord-015306-us58wwmp 2716 12 min min NN cord-015306-us58wwmp 2716 13 , , , cord-015306-us58wwmp 2716 14 followed follow VBN cord-015306-us58wwmp 2716 15 by by IN cord-015306-us58wwmp 2716 16 reperfusion reperfusion NN cord-015306-us58wwmp 2716 17 . . . cord-015306-us58wwmp 2717 1 Animals animal NNS cord-015306-us58wwmp 2717 2 were be VBD cord-015306-us58wwmp 2717 3 sacrificed sacrifice VBN cord-015306-us58wwmp 2717 4 at at IN cord-015306-us58wwmp 2717 5 baseline baseline NN cord-015306-us58wwmp 2717 6 , , , cord-015306-us58wwmp 2717 7 day day NN cord-015306-us58wwmp 2717 8 1,3,10 1,3,10 CD cord-015306-us58wwmp 2717 9 , , , cord-015306-us58wwmp 2717 10 21 21 CD cord-015306-us58wwmp 2717 11 after after IN cord-015306-us58wwmp 2717 12 IRI IRI NNP cord-015306-us58wwmp 2717 13 . . . cord-015306-us58wwmp 2718 1 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2718 2 expression expression NN cord-015306-us58wwmp 2718 3 in in IN cord-015306-us58wwmp 2718 4 KMNCs kmnc NNS cord-015306-us58wwmp 2718 5 were be VBD cord-015306-us58wwmp 2718 6 determined determine VBN cord-015306-us58wwmp 2718 7 using use VBG cord-015306-us58wwmp 2718 8 real real JJ cord-015306-us58wwmp 2718 9 - - HYPH cord-015306-us58wwmp 2718 10 time time NN cord-015306-us58wwmp 2718 11 RT RT NNP cord-015306-us58wwmp 2718 12 - - HYPH cord-015306-us58wwmp 2718 13 PCR PCR NNP cord-015306-us58wwmp 2718 14 and and CC cord-015306-us58wwmp 2718 15 flow flow NN cord-015306-us58wwmp 2718 16 cytometry cytometry NN cord-015306-us58wwmp 2718 17 . . . cord-015306-us58wwmp 2719 1 The the DT cord-015306-us58wwmp 2719 2 percentage percentage NN cord-015306-us58wwmp 2719 3 of of IN cord-015306-us58wwmp 2720 1 Foxp3 foxp3 JJ cord-015306-us58wwmp 2720 2 + + CC cord-015306-us58wwmp 2720 3 Treg Treg NNP cord-015306-us58wwmp 2720 4 in in IN cord-015306-us58wwmp 2720 5 CD4 CD4 NNP cord-015306-us58wwmp 2720 6 + + CC cord-015306-us58wwmp 2720 7 T t NN cord-015306-us58wwmp 2720 8 cells cell NNS cord-015306-us58wwmp 2720 9 was be VBD cord-015306-us58wwmp 2720 10 quantified quantify VBN cord-015306-us58wwmp 2720 11 by by IN cord-015306-us58wwmp 2720 12 flow flow NN cord-015306-us58wwmp 2720 13 cytometry cytometry NN cord-015306-us58wwmp 2720 14 . . . cord-015306-us58wwmp 2721 1 The the DT cord-015306-us58wwmp 2721 2 levels level NNS cord-015306-us58wwmp 2721 3 of of IN cord-015306-us58wwmp 2721 4 TNF TNF NNP cord-015306-us58wwmp 2721 5 - - HYPH cord-015306-us58wwmp 2721 6 α、IFN α、IFN NNP cord-015306-us58wwmp 2721 7 - - HYPH cord-015306-us58wwmp 2721 8 γ、IL-4 γ、IL-4 NNP cord-015306-us58wwmp 2721 9 and and CC cord-015306-us58wwmp 2721 10 IL-10 IL-10 NNP cord-015306-us58wwmp 2721 11 in in IN cord-015306-us58wwmp 2721 12 kidney kidney NN cord-015306-us58wwmp 2721 13 tissue tissue NN cord-015306-us58wwmp 2721 14 were be VBD cord-015306-us58wwmp 2721 15 measured measure VBN cord-015306-us58wwmp 2721 16 using use VBG cord-015306-us58wwmp 2721 17 ELISA ELISA NNP cord-015306-us58wwmp 2721 18 . . . cord-015306-us58wwmp 2722 1 The the DT cord-015306-us58wwmp 2722 2 correlation correlation NN cord-015306-us58wwmp 2722 3 among among IN cord-015306-us58wwmp 2722 4 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2722 5 expression expression NN cord-015306-us58wwmp 2722 6 , , , cord-015306-us58wwmp 2722 7 Foxp3 foxp3 JJ cord-015306-us58wwmp 2722 8 + + CC cord-015306-us58wwmp 2723 1 Treg Treg NNP cord-015306-us58wwmp 2723 2 and and CC cord-015306-us58wwmp 2723 3 cytokine cytokine JJ cord-015306-us58wwmp 2723 4 level level NN cord-015306-us58wwmp 2723 5 was be VBD cord-015306-us58wwmp 2723 6 analyzed analyze VBN cord-015306-us58wwmp 2723 7 . . . cord-015306-us58wwmp 2724 1 Results result NNS cord-015306-us58wwmp 2724 2 : : : cord-015306-us58wwmp 2725 1 The the DT cord-015306-us58wwmp 2725 2 expression expression NN cord-015306-us58wwmp 2725 3 of of IN cord-015306-us58wwmp 2725 4 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2725 5 expression expression NN cord-015306-us58wwmp 2725 6 in in IN cord-015306-us58wwmp 2725 7 KMNCs kmnc NNS cord-015306-us58wwmp 2725 8 from from IN cord-015306-us58wwmp 2725 9 injured injured JJ cord-015306-us58wwmp 2725 10 kidney kidney NN cord-015306-us58wwmp 2725 11 at at IN cord-015306-us58wwmp 2725 12 acute acute JJ cord-015306-us58wwmp 2725 13 stage(day stage(day NNP cord-015306-us58wwmp 2725 14 1 1 CD cord-015306-us58wwmp 2725 15 ) ) -RRB- cord-015306-us58wwmp 2725 16 was be VBD cord-015306-us58wwmp 2725 17 significantly significantly RB cord-015306-us58wwmp 2725 18 higher high JJR cord-015306-us58wwmp 2725 19 than than IN cord-015306-us58wwmp 2725 20 those those DT cord-015306-us58wwmp 2725 21 from from IN cord-015306-us58wwmp 2725 22 uninjured uninjured JJ cord-015306-us58wwmp 2725 23 kidney kidney NN cord-015306-us58wwmp 2725 24 at at IN cord-015306-us58wwmp 2725 25 acute acute JJ cord-015306-us58wwmp 2725 26 stage stage NN cord-015306-us58wwmp 2725 27 and and CC cord-015306-us58wwmp 2725 28 lower low JJR cord-015306-us58wwmp 2725 29 than than IN cord-015306-us58wwmp 2725 30 those those DT cord-015306-us58wwmp 2725 31 from from IN cord-015306-us58wwmp 2725 32 injured injured JJ cord-015306-us58wwmp 2725 33 kidney kidney NN cord-015306-us58wwmp 2725 34 at at IN cord-015306-us58wwmp 2725 35 repair repair NN cord-015306-us58wwmp 2725 36 stage stage NN cord-015306-us58wwmp 2725 37 ( ( -LRB- cord-015306-us58wwmp 2725 38 day day NN cord-015306-us58wwmp 2725 39 3,10 3,10 CD cord-015306-us58wwmp 2725 40 , , , cord-015306-us58wwmp 2725 41 21 21 CD cord-015306-us58wwmp 2725 42 ) ) -RRB- cord-015306-us58wwmp 2725 43 . . . cord-015306-us58wwmp 2726 1 The the DT cord-015306-us58wwmp 2726 2 percentage percentage NN cord-015306-us58wwmp 2726 3 of of IN cord-015306-us58wwmp 2727 1 Foxp3 foxp3 JJ cord-015306-us58wwmp 2727 2 + + CC cord-015306-us58wwmp 2727 3 Treg Treg NNP cord-015306-us58wwmp 2727 4 in in IN cord-015306-us58wwmp 2727 5 CD4 CD4 NNP cord-015306-us58wwmp 2727 6 + + CC cord-015306-us58wwmp 2727 7 T t NN cord-015306-us58wwmp 2727 8 cells cell NNS cord-015306-us58wwmp 2727 9 was be VBD cord-015306-us58wwmp 2727 10 up up RB cord-015306-us58wwmp 2727 11 - - HYPH cord-015306-us58wwmp 2727 12 regulated regulate VBN cord-015306-us58wwmp 2727 13 with with IN cord-015306-us58wwmp 2727 14 time time NN cord-015306-us58wwmp 2727 15 . . . cord-015306-us58wwmp 2728 1 Compared compare VBN cord-015306-us58wwmp 2728 2 with with IN cord-015306-us58wwmp 2728 3 the the DT cord-015306-us58wwmp 2728 4 uninjured uninjured JJ cord-015306-us58wwmp 2728 5 kidney kidney NN cord-015306-us58wwmp 2728 6 , , , cord-015306-us58wwmp 2728 7 the the DT cord-015306-us58wwmp 2728 8 expression expression NN cord-015306-us58wwmp 2728 9 of of IN cord-015306-us58wwmp 2728 10 TNF TNF NNP cord-015306-us58wwmp 2728 11 - - HYPH cord-015306-us58wwmp 2728 12 α α NNP cord-015306-us58wwmp 2728 13 and and CC cord-015306-us58wwmp 2728 14 IFN IFN NNP cord-015306-us58wwmp 2728 15 - - HYPH cord-015306-us58wwmp 2728 16 γ γ NNP cord-015306-us58wwmp 2728 17 increased increase VBD cord-015306-us58wwmp 2728 18 significantly significantly RB cord-015306-us58wwmp 2728 19 in in IN cord-015306-us58wwmp 2728 20 the the DT cord-015306-us58wwmp 2728 21 injured injure VBN cord-015306-us58wwmp 2728 22 kidney kidney NN cord-015306-us58wwmp 2728 23 at at IN cord-015306-us58wwmp 2728 24 acute acute JJ cord-015306-us58wwmp 2728 25 stage stage NN cord-015306-us58wwmp 2728 26 and and CC cord-015306-us58wwmp 2728 27 the the DT cord-015306-us58wwmp 2728 28 expression expression NN cord-015306-us58wwmp 2728 29 of of IN cord-015306-us58wwmp 2728 30 IL-4 IL-4 NNP cord-015306-us58wwmp 2728 31 and and CC cord-015306-us58wwmp 2728 32 IL-10 IL-10 NNP cord-015306-us58wwmp 2728 33 increased increase VBD cord-015306-us58wwmp 2728 34 significantly significantly RB cord-015306-us58wwmp 2728 35 in in IN cord-015306-us58wwmp 2728 36 the the DT cord-015306-us58wwmp 2728 37 injured injure VBN cord-015306-us58wwmp 2728 38 kidney kidney NN cord-015306-us58wwmp 2728 39 at at IN cord-015306-us58wwmp 2728 40 repair repair NN cord-015306-us58wwmp 2728 41 stage stage NN cord-015306-us58wwmp 2728 42 . . . cord-015306-us58wwmp 2729 1 The the DT cord-015306-us58wwmp 2729 2 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2729 3 expression expression NN cord-015306-us58wwmp 2729 4 in in IN cord-015306-us58wwmp 2729 5 KMNCs kmnc NNS cord-015306-us58wwmp 2729 6 at at IN cord-015306-us58wwmp 2729 7 IRI IRI NNP cord-015306-us58wwmp 2729 8 repair repair NN cord-015306-us58wwmp 2729 9 stage stage NN cord-015306-us58wwmp 2729 10 was be VBD cord-015306-us58wwmp 2729 11 positively positively RB cord-015306-us58wwmp 2729 12 related relate VBN cord-015306-us58wwmp 2729 13 with with IN cord-015306-us58wwmp 2729 14 the the DT cord-015306-us58wwmp 2729 15 level level NN cord-015306-us58wwmp 2729 16 of of IN cord-015306-us58wwmp 2730 1 Foxp3 foxp3 JJ cord-015306-us58wwmp 2730 2 + + CC cord-015306-us58wwmp 2730 3 Treg Treg NNP cord-015306-us58wwmp 2730 4 , , , cord-015306-us58wwmp 2730 5 IL-10 IL-10 NNP cord-015306-us58wwmp 2730 6 ( ( -LRB- cord-015306-us58wwmp 2730 7 r=0.81 r=0.81 NN cord-015306-us58wwmp 2730 8 , , , cord-015306-us58wwmp 2730 9 r=0.79 r=0.79 VB cord-015306-us58wwmp 2730 10 respectively respectively RB cord-015306-us58wwmp 2730 11 ; ; : cord-015306-us58wwmp 2730 12 P<0 P<0 NNP cord-015306-us58wwmp 2730 13 . . . cord-015306-us58wwmp 2730 14 05 05 CD cord-015306-us58wwmp 2730 15 ) ) -RRB- cord-015306-us58wwmp 2730 16 , , , cord-015306-us58wwmp 2730 17 but but CC cord-015306-us58wwmp 2730 18 negatively negatively RB cord-015306-us58wwmp 2730 19 related relate VBN cord-015306-us58wwmp 2730 20 with with IN cord-015306-us58wwmp 2730 21 the the DT cord-015306-us58wwmp 2730 22 level level NN cord-015306-us58wwmp 2730 23 of of IN cord-015306-us58wwmp 2730 24 TNF TNF NNP cord-015306-us58wwmp 2730 25 - - HYPH cord-015306-us58wwmp 2730 26 α α NNP cord-015306-us58wwmp 2730 27 and and CC cord-015306-us58wwmp 2730 28 IFN IFN NNP cord-015306-us58wwmp 2730 29 - - HYPH cord-015306-us58wwmp 2730 30 γ γ NNP cord-015306-us58wwmp 2730 31 . . . cord-015306-us58wwmp 2731 1 Conclusion conclusion NN cord-015306-us58wwmp 2731 2 : : : cord-015306-us58wwmp 2732 1 The the DT cord-015306-us58wwmp 2732 2 increased increased JJ cord-015306-us58wwmp 2732 3 expression expression NN cord-015306-us58wwmp 2732 4 of of IN cord-015306-us58wwmp 2732 5 Tim-3 Tim-3 NNP cord-015306-us58wwmp 2732 6 in in IN cord-015306-us58wwmp 2732 7 KMNCs kmnc NNS cord-015306-us58wwmp 2732 8 may may MD cord-015306-us58wwmp 2732 9 take take VB cord-015306-us58wwmp 2732 10 part part NN cord-015306-us58wwmp 2732 11 in in IN cord-015306-us58wwmp 2732 12 the the DT cord-015306-us58wwmp 2732 13 repair repair NN cord-015306-us58wwmp 2732 14 of of IN cord-015306-us58wwmp 2732 15 renal renal JJ cord-015306-us58wwmp 2732 16 IRI IRI NNP cord-015306-us58wwmp 2732 17 and and CC cord-015306-us58wwmp 2732 18 contribute contribute VB cord-015306-us58wwmp 2732 19 to to IN cord-015306-us58wwmp 2732 20 the the DT cord-015306-us58wwmp 2732 21 development development NN cord-015306-us58wwmp 2732 22 of of IN cord-015306-us58wwmp 2733 1 Foxp3 foxp3 JJ cord-015306-us58wwmp 2733 2 + + CC cord-015306-us58wwmp 2734 1 Treg Treg NNP cord-015306-us58wwmp 2734 2 . . . cord-015306-us58wwmp 2735 1 Objective objective NN cord-015306-us58wwmp 2735 2 : : : cord-015306-us58wwmp 2736 1 ( ( -LRB- cord-015306-us58wwmp 2736 2 D+)HUS D+)HUS NNP cord-015306-us58wwmp 2736 3 is be VBZ cord-015306-us58wwmp 2736 4 a a DT cord-015306-us58wwmp 2736 5 critical critical JJ cord-015306-us58wwmp 2736 6 health health NN cord-015306-us58wwmp 2736 7 problem problem NN cord-015306-us58wwmp 2736 8 in in IN cord-015306-us58wwmp 2736 9 Argentina Argentina NNP cord-015306-us58wwmp 2736 10 since since IN cord-015306-us58wwmp 2736 11 it -PRON- PRP cord-015306-us58wwmp 2736 12 is be VBZ cord-015306-us58wwmp 2736 13 the the DT cord-015306-us58wwmp 2736 14 main main JJ cord-015306-us58wwmp 2736 15 cause cause NN cord-015306-us58wwmp 2736 16 of of IN cord-015306-us58wwmp 2736 17 acute acute JJ cord-015306-us58wwmp 2736 18 renal renal JJ cord-015306-us58wwmp 2736 19 failure failure NN cord-015306-us58wwmp 2736 20 in in IN cord-015306-us58wwmp 2736 21 children child NNS cord-015306-us58wwmp 2736 22 and and CC cord-015306-us58wwmp 2736 23 the the DT cord-015306-us58wwmp 2736 24 second second JJ cord-015306-us58wwmp 2736 25 cause cause NN cord-015306-us58wwmp 2736 26 of of IN cord-015306-us58wwmp 2736 27 chronic chronic JJ cord-015306-us58wwmp 2736 28 renal renal JJ cord-015306-us58wwmp 2736 29 failure failure NN cord-015306-us58wwmp 2736 30 . . . cord-015306-us58wwmp 2737 1 Fecal fecal JJ cord-015306-us58wwmp 2737 2 contamination contamination NN cord-015306-us58wwmp 2737 3 of of IN cord-015306-us58wwmp 2737 4 food food NN cord-015306-us58wwmp 2737 5 and and CC cord-015306-us58wwmp 2737 6 drinking drinking NN cord-015306-us58wwmp 2737 7 water water NN cord-015306-us58wwmp 2737 8 by by IN cord-015306-us58wwmp 2737 9 asymptomatic asymptomatic JJ cord-015306-us58wwmp 2737 10 cattle cattle NNS cord-015306-us58wwmp 2737 11 is be VBZ cord-015306-us58wwmp 2737 12 often often RB cord-015306-us58wwmp 2737 13 the the DT cord-015306-us58wwmp 2737 14 source source NN cord-015306-us58wwmp 2737 15 although although IN cord-015306-us58wwmp 2737 16 secondary secondary JJ cord-015306-us58wwmp 2737 17 infection infection NN cord-015306-us58wwmp 2737 18 through through IN cord-015306-us58wwmp 2737 19 personto personto NN cord-015306-us58wwmp 2737 20 - - HYPH cord-015306-us58wwmp 2737 21 person person NN cord-015306-us58wwmp 2737 22 contact contact NN cord-015306-us58wwmp 2737 23 may may MD cord-015306-us58wwmp 2737 24 also also RB cord-015306-us58wwmp 2737 25 occur occur VB cord-015306-us58wwmp 2737 26 . . . cord-015306-us58wwmp 2738 1 Occasionally occasionally RB cord-015306-us58wwmp 2738 2 in in IN cord-015306-us58wwmp 2738 3 ( ( -LRB- cord-015306-us58wwmp 2738 4 D+ d+ NN cord-015306-us58wwmp 2738 5 ) ) -RRB- cord-015306-us58wwmp 2738 6 HUS HUS NNP cord-015306-us58wwmp 2738 7 , , , cord-015306-us58wwmp 2738 8 the the DT cord-015306-us58wwmp 2738 9 onset onset NN cord-015306-us58wwmp 2738 10 among among IN cord-015306-us58wwmp 2738 11 affected affected JJ cord-015306-us58wwmp 2738 12 siblings sibling NNS cord-015306-us58wwmp 2738 13 occurred occur VBD cord-015306-us58wwmp 2738 14 within within IN cord-015306-us58wwmp 2738 15 a a DT cord-015306-us58wwmp 2738 16 short short JJ cord-015306-us58wwmp 2738 17 time time NN cord-015306-us58wwmp 2738 18 of of IN cord-015306-us58wwmp 2738 19 each each DT cord-015306-us58wwmp 2738 20 other other JJ cord-015306-us58wwmp 2738 21 . . . cord-015306-us58wwmp 2739 1 To to TO cord-015306-us58wwmp 2739 2 evaluate evaluate VB cord-015306-us58wwmp 2739 3 the the DT cord-015306-us58wwmp 2739 4 risk risk NN cord-015306-us58wwmp 2739 5 and and CC cord-015306-us58wwmp 2739 6 clinical clinical JJ cord-015306-us58wwmp 2739 7 severity severity NN cord-015306-us58wwmp 2739 8 of of IN cord-015306-us58wwmp 2739 9 illness illness NN cord-015306-us58wwmp 2739 10 for for IN cord-015306-us58wwmp 2739 11 childhood childhood NN cord-015306-us58wwmp 2739 12 ( ( -LRB- cord-015306-us58wwmp 2739 13 D+)HUS D+)HUS NNP cord-015306-us58wwmp 2739 14 in in IN cord-015306-us58wwmp 2739 15 siblings sibling NNS cord-015306-us58wwmp 2739 16 . . . cord-015306-us58wwmp 2740 1 Methods method NNS cord-015306-us58wwmp 2740 2 : : : cord-015306-us58wwmp 2740 3 We -PRON- PRP cord-015306-us58wwmp 2740 4 retrospectively retrospectively RB cord-015306-us58wwmp 2740 5 analyzed analyze VBD cord-015306-us58wwmp 2740 6 the the DT cord-015306-us58wwmp 2740 7 clinical clinical JJ cord-015306-us58wwmp 2740 8 records record NNS cord-015306-us58wwmp 2740 9 of of IN cord-015306-us58wwmp 2740 10 133 133 CD cord-015306-us58wwmp 2740 11 children child NNS cord-015306-us58wwmp 2740 12 with with IN cord-015306-us58wwmp 2740 13 D+HUS d+hu NNS cord-015306-us58wwmp 2740 14 that that WDT cord-015306-us58wwmp 2740 15 were be VBD cord-015306-us58wwmp 2740 16 admitted admit VBN cord-015306-us58wwmp 2740 17 in in IN cord-015306-us58wwmp 2740 18 our -PRON- PRP$ cord-015306-us58wwmp 2740 19 pediatric pediatric JJ cord-015306-us58wwmp 2740 20 department department NN cord-015306-us58wwmp 2740 21 between between IN cord-015306-us58wwmp 2740 22 March March NNP cord-015306-us58wwmp 2740 23 1997 1997 CD cord-015306-us58wwmp 2740 24 and and CC cord-015306-us58wwmp 2740 25 December December NNP cord-015306-us58wwmp 2740 26 2012 2012 CD cord-015306-us58wwmp 2740 27 . . . cord-015306-us58wwmp 2741 1 Results result NNS cord-015306-us58wwmp 2741 2 : : : cord-015306-us58wwmp 2742 1 ( ( -LRB- cord-015306-us58wwmp 2742 2 D+ D+ NNP cord-015306-us58wwmp 2742 3 ) ) -RRB- cord-015306-us58wwmp 2742 4 HUS HUS NNP cord-015306-us58wwmp 2742 5 occurred occur VBD cord-015306-us58wwmp 2742 6 in in IN cord-015306-us58wwmp 2742 7 2 2 CD cord-015306-us58wwmp 2742 8 siblings sibling NNS cord-015306-us58wwmp 2742 9 in in IN cord-015306-us58wwmp 2742 10 4 4 CD cord-015306-us58wwmp 2742 11 of of IN cord-015306-us58wwmp 2742 12 the the DT cord-015306-us58wwmp 2742 13 129 129 CD cord-015306-us58wwmp 2742 14 families family NNS cord-015306-us58wwmp 2742 15 studied study VBD cord-015306-us58wwmp 2742 16 ( ( -LRB- cord-015306-us58wwmp 2742 17 3 3 CD cord-015306-us58wwmp 2742 18 % % NN cord-015306-us58wwmp 2742 19 ) ) -RRB- cord-015306-us58wwmp 2742 20 . . . cord-015306-us58wwmp 2743 1 16 16 CD cord-015306-us58wwmp 2743 2 patients patient NNS cord-015306-us58wwmp 2743 3 had have VBD cord-015306-us58wwmp 2743 4 an an DT cord-015306-us58wwmp 2743 5 affected affect VBN cord-015306-us58wwmp 2743 6 sibling sibling NN cord-015306-us58wwmp 2743 7 with with IN cord-015306-us58wwmp 2743 8 diarrhea diarrhea NN cord-015306-us58wwmp 2743 9 and and CC cord-015306-us58wwmp 2743 10 4 4 CD cord-015306-us58wwmp 2743 11 progressed progress VBD cord-015306-us58wwmp 2743 12 to to IN cord-015306-us58wwmp 2743 13 HUS HUS NNP cord-015306-us58wwmp 2743 14 ( ( -LRB- cord-015306-us58wwmp 2743 15 25 25 CD cord-015306-us58wwmp 2743 16 % % NN cord-015306-us58wwmp 2743 17 ) ) -RRB- cord-015306-us58wwmp 2743 18 . . . cord-015306-us58wwmp 2744 1 Family family NN cord-015306-us58wwmp 2744 2 cases case NNS cord-015306-us58wwmp 2744 3 : : : cord-015306-us58wwmp 2745 1 Mean mean JJ cord-015306-us58wwmp 2745 2 age age NN cord-015306-us58wwmp 2745 3 : : : cord-015306-us58wwmp 2745 4 28 28 CD cord-015306-us58wwmp 2745 5 months month NNS cord-015306-us58wwmp 2745 6 , , , cord-015306-us58wwmp 2745 7 5 5 CD cord-015306-us58wwmp 2745 8 were be VBD cord-015306-us58wwmp 2745 9 girls girl NNS cord-015306-us58wwmp 2745 10 . . . cord-015306-us58wwmp 2746 1 The the DT cord-015306-us58wwmp 2746 2 mean mean JJ cord-015306-us58wwmp 2746 3 duration duration NN cord-015306-us58wwmp 2746 4 of of IN cord-015306-us58wwmp 2746 5 interval interval NN cord-015306-us58wwmp 2746 6 between between IN cord-015306-us58wwmp 2746 7 HUS HUS NNP cord-015306-us58wwmp 2746 8 episodes episode NNS cord-015306-us58wwmp 2746 9 was be VBD cord-015306-us58wwmp 2746 10 4 4 CD cord-015306-us58wwmp 2746 11 days day NNS cord-015306-us58wwmp 2746 12 . . . cord-015306-us58wwmp 2747 1 Second second JJ cord-015306-us58wwmp 2747 2 family family NN cord-015306-us58wwmp 2747 3 members member NNS cord-015306-us58wwmp 2747 4 had have VBD cord-015306-us58wwmp 2747 5 prolonged prolong VBN cord-015306-us58wwmp 2747 6 oligoanuria oligoanuria NNS cord-015306-us58wwmp 2747 7 ( ( -LRB- cord-015306-us58wwmp 2747 8 3 3 CD cord-015306-us58wwmp 2747 9 vs vs IN cord-015306-us58wwmp 2747 10 12 12 CD cord-015306-us58wwmp 2747 11 days day NNS cord-015306-us58wwmp 2747 12 ) ) -RRB- cord-015306-us58wwmp 2747 13 and and CC cord-015306-us58wwmp 2747 14 a a DT cord-015306-us58wwmp 2747 15 most most JJS cord-015306-us58wwmp 2747 16 of of IN cord-015306-us58wwmp 2747 17 them -PRON- PRP cord-015306-us58wwmp 2747 18 developed develop VBD cord-015306-us58wwmp 2747 19 neurological neurological JJ cord-015306-us58wwmp 2747 20 complications complication NNS cord-015306-us58wwmp 2747 21 . . . cord-015306-us58wwmp 2748 1 Long long JJ cord-015306-us58wwmp 2748 2 - - HYPH cord-015306-us58wwmp 2748 3 term term NN cord-015306-us58wwmp 2748 4 renal renal JJ cord-015306-us58wwmp 2748 5 complications complication NNS cord-015306-us58wwmp 2748 6 were be VBD cord-015306-us58wwmp 2748 7 more more RBR cord-015306-us58wwmp 2748 8 frequent frequent JJ cord-015306-us58wwmp 2748 9 in in IN cord-015306-us58wwmp 2748 10 this this DT cord-015306-us58wwmp 2748 11 group group NN cord-015306-us58wwmp 2748 12 , , , cord-015306-us58wwmp 2748 13 but but CC cord-015306-us58wwmp 2748 14 differences difference NNS cord-015306-us58wwmp 2748 15 were be VBD cord-015306-us58wwmp 2748 16 not not RB cord-015306-us58wwmp 2748 17 statistically statistically RB cord-015306-us58wwmp 2748 18 significant significant JJ cord-015306-us58wwmp 2748 19 . . . cord-015306-us58wwmp 2749 1 Conclusion conclusion NN cord-015306-us58wwmp 2749 2 : : : cord-015306-us58wwmp 2750 1 These these DT cord-015306-us58wwmp 2750 2 findings finding NNS cord-015306-us58wwmp 2750 3 emphasize emphasize VBP cord-015306-us58wwmp 2750 4 the the DT cord-015306-us58wwmp 2750 5 potential potential NN cord-015306-us58wwmp 2750 6 for for IN cord-015306-us58wwmp 2750 7 extensive extensive JJ cord-015306-us58wwmp 2750 8 intra intra JJ cord-015306-us58wwmp 2750 9 - - JJ cord-015306-us58wwmp 2750 10 familiar familiar JJ cord-015306-us58wwmp 2750 11 transmission transmission NN cord-015306-us58wwmp 2750 12 of of IN cord-015306-us58wwmp 2750 13 STEC STEC NNP cord-015306-us58wwmp 2750 14 , , , cord-015306-us58wwmp 2750 15 especially especially RB cord-015306-us58wwmp 2750 16 between between IN cord-015306-us58wwmp 2750 17 siblings sibling NNS cord-015306-us58wwmp 2750 18 . . . cord-015306-us58wwmp 2751 1 A a DT cord-015306-us58wwmp 2751 2 second second JJ cord-015306-us58wwmp 2751 3 family family NN cord-015306-us58wwmp 2751 4 member member NN cord-015306-us58wwmp 2751 5 might may MD cord-015306-us58wwmp 2751 6 also also RB cord-015306-us58wwmp 2751 7 develop develop VB cord-015306-us58wwmp 2751 8 an an DT cord-015306-us58wwmp 2751 9 even even RB cord-015306-us58wwmp 2751 10 more more RBR cord-015306-us58wwmp 2751 11 severe severe JJ cord-015306-us58wwmp 2751 12 HUS HUS NNP cord-015306-us58wwmp 2751 13 episode episode NN cord-015306-us58wwmp 2751 14 , , , cord-015306-us58wwmp 2751 15 so so IN cord-015306-us58wwmp 2751 16 siblings sibling NNS cord-015306-us58wwmp 2751 17 should should MD cord-015306-us58wwmp 2751 18 be be VB cord-015306-us58wwmp 2751 19 kept keep VBN cord-015306-us58wwmp 2751 20 under under IN cord-015306-us58wwmp 2751 21 close close JJ cord-015306-us58wwmp 2751 22 surveillance surveillance NN cord-015306-us58wwmp 2751 23 . . . cord-015306-us58wwmp 2752 1 Objective objective NN cord-015306-us58wwmp 2752 2 : : : cord-015306-us58wwmp 2753 1 Kawasaki Kawasaki NNP cord-015306-us58wwmp 2753 2 disease disease NN cord-015306-us58wwmp 2753 3 ( ( -LRB- cord-015306-us58wwmp 2753 4 KD KD NNP cord-015306-us58wwmp 2753 5 ) ) -RRB- cord-015306-us58wwmp 2753 6 is be VBZ cord-015306-us58wwmp 2753 7 a a DT cord-015306-us58wwmp 2753 8 common common JJ cord-015306-us58wwmp 2753 9 cause cause NN cord-015306-us58wwmp 2753 10 of of IN cord-015306-us58wwmp 2753 11 systemic systemic JJ cord-015306-us58wwmp 2753 12 vasculitis vasculitis NN cord-015306-us58wwmp 2753 13 in in IN cord-015306-us58wwmp 2753 14 children child NNS cord-015306-us58wwmp 2753 15 . . . cord-015306-us58wwmp 2754 1 Other other JJ cord-015306-us58wwmp 2754 2 than than IN cord-015306-us58wwmp 2754 3 well well RB cord-015306-us58wwmp 2754 4 known know VBN cord-015306-us58wwmp 2754 5 complications complication NNS cord-015306-us58wwmp 2754 6 like like IN cord-015306-us58wwmp 2754 7 coronary coronary JJ cord-015306-us58wwmp 2754 8 artery artery NN cord-015306-us58wwmp 2754 9 aneurysm aneurysm NN cord-015306-us58wwmp 2754 10 , , , cord-015306-us58wwmp 2754 11 there there EX cord-015306-us58wwmp 2754 12 have have VBP cord-015306-us58wwmp 2754 13 been be VBN cord-015306-us58wwmp 2754 14 few few JJ cord-015306-us58wwmp 2754 15 reports report NNS cord-015306-us58wwmp 2754 16 of of IN cord-015306-us58wwmp 2754 17 this this DT cord-015306-us58wwmp 2754 18 disease disease NN cord-015306-us58wwmp 2754 19 involvement involvement NN cord-015306-us58wwmp 2754 20 in in IN cord-015306-us58wwmp 2754 21 renal renal JJ cord-015306-us58wwmp 2754 22 system system NN cord-015306-us58wwmp 2754 23 . . . cord-015306-us58wwmp 2755 1 According accord VBG cord-015306-us58wwmp 2755 2 to to IN cord-015306-us58wwmp 2755 3 the the DT cord-015306-us58wwmp 2755 4 study study NN cord-015306-us58wwmp 2755 5 from from IN cord-015306-us58wwmp 2755 6 Wang Wang NNP cord-015306-us58wwmp 2755 7 JN JN NNP cord-015306-us58wwmp 2756 1 et.al et.al NNS cord-015306-us58wwmp 2756 2 , , , cord-015306-us58wwmp 2756 3 52 52 CD cord-015306-us58wwmp 2756 4 % % NN cord-015306-us58wwmp 2756 5 ( ( -LRB- cord-015306-us58wwmp 2756 6 26 26 CD cord-015306-us58wwmp 2756 7 out out IN cord-015306-us58wwmp 2756 8 of of IN cord-015306-us58wwmp 2756 9 50 50 CD cord-015306-us58wwmp 2756 10 ) ) -RRB- cord-015306-us58wwmp 2756 11 of of IN cord-015306-us58wwmp 2756 12 the the DT cord-015306-us58wwmp 2756 13 patients patient NNS cord-015306-us58wwmp 2756 14 who who WP cord-015306-us58wwmp 2756 15 suffered suffer VBD cord-015306-us58wwmp 2756 16 from from IN cord-015306-us58wwmp 2756 17 KD KD NNP cord-015306-us58wwmp 2756 18 showed show VBD cord-015306-us58wwmp 2756 19 renal renal JJ cord-015306-us58wwmp 2756 20 inflammatory inflammatory JJ cord-015306-us58wwmp 2756 21 foci foci NN cord-015306-us58wwmp 2756 22 in in IN cord-015306-us58wwmp 2756 23 DMSA DMSA NNS cord-015306-us58wwmp 2756 24 renal renal JJ cord-015306-us58wwmp 2756 25 SPECT spect NN cord-015306-us58wwmp 2756 26 which which WDT cord-015306-us58wwmp 2756 27 suggested suggest VBD cord-015306-us58wwmp 2756 28 a a DT cord-015306-us58wwmp 2756 29 possibility possibility NN cord-015306-us58wwmp 2756 30 of of IN cord-015306-us58wwmp 2756 31 renal renal JJ cord-015306-us58wwmp 2756 32 scar scar NN cord-015306-us58wwmp 2756 33 formation formation NN cord-015306-us58wwmp 2756 34 subsequent subsequent JJ cord-015306-us58wwmp 2756 35 to to IN cord-015306-us58wwmp 2756 36 KD KD NNP cord-015306-us58wwmp 2756 37 . . . cord-015306-us58wwmp 2757 1 Therefore therefore RB cord-015306-us58wwmp 2757 2 , , , cord-015306-us58wwmp 2757 3 this this DT cord-015306-us58wwmp 2757 4 study study NN cord-015306-us58wwmp 2757 5 was be VBD cord-015306-us58wwmp 2757 6 performed perform VBN cord-015306-us58wwmp 2757 7 to to TO cord-015306-us58wwmp 2757 8 verify verify VB cord-015306-us58wwmp 2757 9 the the DT cord-015306-us58wwmp 2757 10 renal renal JJ cord-015306-us58wwmp 2757 11 inflammation inflammation NN cord-015306-us58wwmp 2757 12 following follow VBG cord-015306-us58wwmp 2757 13 KD KD NNP cord-015306-us58wwmp 2757 14 . . . cord-015306-us58wwmp 2758 1 Methods method NNS cord-015306-us58wwmp 2758 2 : : : cord-015306-us58wwmp 2759 1 From from IN cord-015306-us58wwmp 2759 2 March March NNP cord-015306-us58wwmp 2759 3 2011 2011 CD cord-015306-us58wwmp 2759 4 to to IN cord-015306-us58wwmp 2759 5 October October NNP cord-015306-us58wwmp 2759 6 2011 2011 CD cord-015306-us58wwmp 2759 7 , , , cord-015306-us58wwmp 2759 8 15 15 CD cord-015306-us58wwmp 2759 9 patients patient NNS cord-015306-us58wwmp 2759 10 who who WP cord-015306-us58wwmp 2759 11 were be VBD cord-015306-us58wwmp 2759 12 diagnosed diagnose VBN cord-015306-us58wwmp 2759 13 as as IN cord-015306-us58wwmp 2759 14 KD KD NNP cord-015306-us58wwmp 2759 15 at at IN cord-015306-us58wwmp 2759 16 National National NNP cord-015306-us58wwmp 2759 17 Health Health NNP cord-015306-us58wwmp 2759 18 Insurance Insurance NNP cord-015306-us58wwmp 2759 19 Service Service NNP cord-015306-us58wwmp 2759 20 Ilsan Ilsan NNP cord-015306-us58wwmp 2759 21 Hospital Hospital NNP cord-015306-us58wwmp 2759 22 were be VBD cord-015306-us58wwmp 2759 23 enrolled enrol VBN cord-015306-us58wwmp 2759 24 to to IN cord-015306-us58wwmp 2759 25 the the DT cord-015306-us58wwmp 2759 26 study study NN cord-015306-us58wwmp 2759 27 . . . cord-015306-us58wwmp 2760 1 All all DT cord-015306-us58wwmp 2760 2 of of IN cord-015306-us58wwmp 2760 3 the the DT cord-015306-us58wwmp 2760 4 patients patient NNS cord-015306-us58wwmp 2760 5 underwent undergo VBD cord-015306-us58wwmp 2760 6 DMSA DMSA NNS cord-015306-us58wwmp 2760 7 renal renal JJ cord-015306-us58wwmp 2760 8 SPECT SPECT NNS cord-015306-us58wwmp 2760 9 to to TO cord-015306-us58wwmp 2760 10 evaluate evaluate VB cord-015306-us58wwmp 2760 11 renal renal JJ cord-015306-us58wwmp 2760 12 involvement involvement NN cord-015306-us58wwmp 2760 13 during during IN cord-015306-us58wwmp 2760 14 their -PRON- PRP$ cord-015306-us58wwmp 2760 15 acute acute JJ cord-015306-us58wwmp 2760 16 phase phase NN cord-015306-us58wwmp 2760 17 of of IN cord-015306-us58wwmp 2760 18 KD KD NNP cord-015306-us58wwmp 2760 19 . . . cord-015306-us58wwmp 2761 1 Echocardiography echocardiography NN cord-015306-us58wwmp 2761 2 was be VBD cord-015306-us58wwmp 2761 3 performed perform VBN cord-015306-us58wwmp 2761 4 to to TO cord-015306-us58wwmp 2761 5 assess assess VB cord-015306-us58wwmp 2761 6 cardiac cardiac JJ cord-015306-us58wwmp 2761 7 involvement involvement NN cord-015306-us58wwmp 2761 8 such such JJ cord-015306-us58wwmp 2761 9 as as IN cord-015306-us58wwmp 2761 10 coronary coronary JJ cord-015306-us58wwmp 2761 11 artery artery NN cord-015306-us58wwmp 2761 12 aneurysm aneurysm NN cord-015306-us58wwmp 2761 13 . . . cord-015306-us58wwmp 2762 1 Complete complete JJ cord-015306-us58wwmp 2762 2 blood blood NN cord-015306-us58wwmp 2762 3 cell cell NN cord-015306-us58wwmp 2762 4 counts count NNS cord-015306-us58wwmp 2762 5 , , , cord-015306-us58wwmp 2762 6 aspartate aspartate NN cord-015306-us58wwmp 2762 7 amino amino NN cord-015306-us58wwmp 2762 8 - - HYPH cord-015306-us58wwmp 2762 9 transferase transferase NN cord-015306-us58wwmp 2762 10 , , , cord-015306-us58wwmp 2762 11 alanin alanin NNS cord-015306-us58wwmp 2762 12 amino amino NN cord-015306-us58wwmp 2762 13 - - HYPH cord-015306-us58wwmp 2762 14 transferase transferase NN cord-015306-us58wwmp 2762 15 , , , cord-015306-us58wwmp 2762 16 albumin albumin NN cord-015306-us58wwmp 2762 17 , , , cord-015306-us58wwmp 2762 18 c c NN cord-015306-us58wwmp 2762 19 - - HYPH cord-015306-us58wwmp 2762 20 reactive reactive JJ cord-015306-us58wwmp 2762 21 protein protein NN cord-015306-us58wwmp 2762 22 , , , cord-015306-us58wwmp 2762 23 and and CC cord-015306-us58wwmp 2762 24 BUN bun NN cord-015306-us58wwmp 2762 25 / / SYM cord-015306-us58wwmp 2762 26 Creatinine creatinine NN cord-015306-us58wwmp 2762 27 were be VBD cord-015306-us58wwmp 2762 28 measured measure VBN cord-015306-us58wwmp 2762 29 . . . cord-015306-us58wwmp 2763 1 Also also RB cord-015306-us58wwmp 2763 2 Urine Urine NNP cord-015306-us58wwmp 2763 3 β2microglobulin β2microglobulin NNP cord-015306-us58wwmp 2763 4 was be VBD cord-015306-us58wwmp 2763 5 measured measure VBN cord-015306-us58wwmp 2763 6 to to TO cord-015306-us58wwmp 2763 7 assess assess VB cord-015306-us58wwmp 2763 8 renal renal JJ cord-015306-us58wwmp 2763 9 tubular tubular JJ cord-015306-us58wwmp 2763 10 function function NN cord-015306-us58wwmp 2763 11 . . . cord-015306-us58wwmp 2764 1 Addition addition NN cord-015306-us58wwmp 2764 2 to to IN cord-015306-us58wwmp 2764 3 fever fever NN cord-015306-us58wwmp 2764 4 of of IN cord-015306-us58wwmp 2764 5 more more JJR cord-015306-us58wwmp 2764 6 than than IN cord-015306-us58wwmp 2764 7 five five CD cord-015306-us58wwmp 2764 8 days day NNS cord-015306-us58wwmp 2764 9 of of IN cord-015306-us58wwmp 2764 10 duration duration NN cord-015306-us58wwmp 2764 11 , , , cord-015306-us58wwmp 2764 12 4 4 CD cord-015306-us58wwmp 2764 13 of of IN cord-015306-us58wwmp 2764 14 the the DT cord-015306-us58wwmp 2764 15 following follow VBG cord-015306-us58wwmp 2764 16 symptoms symptom NNS cord-015306-us58wwmp 2764 17 , , , cord-015306-us58wwmp 2764 18 rash rash JJ cord-015306-us58wwmp 2764 19 , , , cord-015306-us58wwmp 2764 20 conjunctival conjunctival JJ cord-015306-us58wwmp 2764 21 injection injection NN cord-015306-us58wwmp 2764 22 , , , cord-015306-us58wwmp 2764 23 changes change NNS cord-015306-us58wwmp 2764 24 of of IN cord-015306-us58wwmp 2764 25 lips lip NNS cord-015306-us58wwmp 2764 26 or or CC cord-015306-us58wwmp 2764 27 oral oral JJ cord-015306-us58wwmp 2764 28 mucosa mucosa NN cord-015306-us58wwmp 2764 29 , , , cord-015306-us58wwmp 2764 30 erythema erythema NN cord-015306-us58wwmp 2764 31 and and CC cord-015306-us58wwmp 2764 32 swelling swelling NN cord-015306-us58wwmp 2764 33 of of IN cord-015306-us58wwmp 2764 34 hands hand NNS cord-015306-us58wwmp 2764 35 and and CC cord-015306-us58wwmp 2764 36 feet foot NNS cord-015306-us58wwmp 2764 37 and and CC cord-015306-us58wwmp 2764 38 cervical cervical JJ cord-015306-us58wwmp 2764 39 lymphadenopathy lymphadenopathy NN cord-015306-us58wwmp 2764 40 , , , cord-015306-us58wwmp 2764 41 was be VBD cord-015306-us58wwmp 2764 42 the the DT cord-015306-us58wwmp 2764 43 diagnostic diagnostic JJ cord-015306-us58wwmp 2764 44 criteria criterion NNS cord-015306-us58wwmp 2764 45 for for IN cord-015306-us58wwmp 2764 46 KD KD NNP cord-015306-us58wwmp 2764 47 . . . cord-015306-us58wwmp 2765 1 Results result NNS cord-015306-us58wwmp 2765 2 : : : cord-015306-us58wwmp 2766 1 Among among IN cord-015306-us58wwmp 2766 2 the the DT cord-015306-us58wwmp 2766 3 15 15 CD cord-015306-us58wwmp 2766 4 patients patient NNS cord-015306-us58wwmp 2766 5 , , , cord-015306-us58wwmp 2766 6 80 80 CD cord-015306-us58wwmp 2766 7 % % NN cord-015306-us58wwmp 2766 8 showed show VBD cord-015306-us58wwmp 2766 9 increased increase VBN cord-015306-us58wwmp 2766 10 white white JJ cord-015306-us58wwmp 2766 11 blood blood NN cord-015306-us58wwmp 2766 12 cell cell NN cord-015306-us58wwmp 2766 13 s s NN cord-015306-us58wwmp 2766 14 ( ( -LRB- cord-015306-us58wwmp 2766 15 WBC WBC NNP cord-015306-us58wwmp 2766 16 ) ) -RRB- cord-015306-us58wwmp 2766 17 and and CC cord-015306-us58wwmp 2766 18 47 47 CD cord-015306-us58wwmp 2766 19 % % NN cord-015306-us58wwmp 2766 20 showed show VBD cord-015306-us58wwmp 2766 21 elevated elevate VBN cord-015306-us58wwmp 2766 22 AST AST NNP cord-015306-us58wwmp 2766 23 / / SYM cord-015306-us58wwmp 2766 24 ALT alt NN cord-015306-us58wwmp 2766 25 level level NN cord-015306-us58wwmp 2766 26 . . . cord-015306-us58wwmp 2767 1 Serum serum NN cord-015306-us58wwmp 2767 2 albumin albumin NN cord-015306-us58wwmp 2767 3 was be VBD cord-015306-us58wwmp 2767 4 below below IN cord-015306-us58wwmp 2767 5 4.0 4.0 CD cord-015306-us58wwmp 2767 6 g g NN cord-015306-us58wwmp 2767 7 / / SYM cord-015306-us58wwmp 2767 8 dl dl NN cord-015306-us58wwmp 2767 9 in in IN cord-015306-us58wwmp 2767 10 93 93 CD cord-015306-us58wwmp 2767 11 % % NN cord-015306-us58wwmp 2767 12 of of IN cord-015306-us58wwmp 2767 13 the the DT cord-015306-us58wwmp 2767 14 patients patient NNS cord-015306-us58wwmp 2767 15 . . . cord-015306-us58wwmp 2768 1 All all DT cord-015306-us58wwmp 2768 2 of of IN cord-015306-us58wwmp 2768 3 the the DT cord-015306-us58wwmp 2768 4 patients patient NNS cord-015306-us58wwmp 2768 5 presented present VBD cord-015306-us58wwmp 2768 6 normal normal JJ cord-015306-us58wwmp 2768 7 renal renal JJ cord-015306-us58wwmp 2768 8 function function NN cord-015306-us58wwmp 2768 9 test test NN cord-015306-us58wwmp 2768 10 . . . cord-015306-us58wwmp 2769 1 In in IN cord-015306-us58wwmp 2769 2 urinalysis urinalysis NN cord-015306-us58wwmp 2769 3 , , , cord-015306-us58wwmp 2769 4 hematuria hematuria NN cord-015306-us58wwmp 2769 5 and and CC cord-015306-us58wwmp 2769 6 pyuria pyuria NNS cord-015306-us58wwmp 2769 7 were be VBD cord-015306-us58wwmp 2769 8 observed observe VBN cord-015306-us58wwmp 2769 9 in in IN cord-015306-us58wwmp 2769 10 13 13 CD cord-015306-us58wwmp 2769 11 % % NN cord-015306-us58wwmp 2769 12 and and CC cord-015306-us58wwmp 2769 13 33 33 CD cord-015306-us58wwmp 2769 14 % % NN cord-015306-us58wwmp 2769 15 respectively respectively RB cord-015306-us58wwmp 2769 16 . . . cord-015306-us58wwmp 2770 1 Echocardiography echocardiography NN cord-015306-us58wwmp 2770 2 revealed reveal VBD cord-015306-us58wwmp 2770 3 coronary coronary JJ cord-015306-us58wwmp 2770 4 artery artery NN cord-015306-us58wwmp 2770 5 aneurysm aneurysm NN cord-015306-us58wwmp 2770 6 in in IN cord-015306-us58wwmp 2770 7 33 33 CD cord-015306-us58wwmp 2770 8 % % NN cord-015306-us58wwmp 2770 9 of of IN cord-015306-us58wwmp 2770 10 the the DT cord-015306-us58wwmp 2770 11 patients patient NNS cord-015306-us58wwmp 2770 12 . . . cord-015306-us58wwmp 2771 1 Urine urine NN cord-015306-us58wwmp 2771 2 β2-microglobulin β2-microglobulin NNP cord-015306-us58wwmp 2771 3 was be VBD cord-015306-us58wwmp 2771 4 elevated elevate VBN cord-015306-us58wwmp 2771 5 in in IN cord-015306-us58wwmp 2771 6 46 46 CD cord-015306-us58wwmp 2771 7 % % NN cord-015306-us58wwmp 2771 8 . . . cord-015306-us58wwmp 2772 1 Regardless regardless RB cord-015306-us58wwmp 2772 2 abnormal abnormal JJ cord-015306-us58wwmp 2772 3 findings finding NNS cord-015306-us58wwmp 2772 4 in in IN cord-015306-us58wwmp 2772 5 urinalysis urinalysis NN cord-015306-us58wwmp 2772 6 and and CC cord-015306-us58wwmp 2772 7 elevated elevated JJ cord-015306-us58wwmp 2772 8 β2microglobulin β2microglobulin NNP cord-015306-us58wwmp 2772 9 , , , cord-015306-us58wwmp 2772 10 no no DT cord-015306-us58wwmp 2772 11 significant significant JJ cord-015306-us58wwmp 2772 12 findings finding NNS cord-015306-us58wwmp 2772 13 were be VBD cord-015306-us58wwmp 2772 14 observed observe VBN cord-015306-us58wwmp 2772 15 in in IN cord-015306-us58wwmp 2772 16 DMSA DMSA NNP cord-015306-us58wwmp 2772 17 renal renal JJ cord-015306-us58wwmp 2772 18 SPECT SPECT NNS cord-015306-us58wwmp 2772 19 . . . cord-015306-us58wwmp 2773 1 Conclusion conclusion NN cord-015306-us58wwmp 2773 2 : : : cord-015306-us58wwmp 2774 1 According accord VBG cord-015306-us58wwmp 2774 2 to to IN cord-015306-us58wwmp 2774 3 the the DT cord-015306-us58wwmp 2774 4 study study NN cord-015306-us58wwmp 2774 5 , , , cord-015306-us58wwmp 2774 6 mild mild JJ cord-015306-us58wwmp 2774 7 abnormality abnormality NN cord-015306-us58wwmp 2774 8 in in IN cord-015306-us58wwmp 2774 9 the the DT cord-015306-us58wwmp 2774 10 urinalysis urinalysis NN cord-015306-us58wwmp 2774 11 and and CC cord-015306-us58wwmp 2774 12 elevated elevated JJ cord-015306-us58wwmp 2774 13 β2-microglobulin β2-microglobulin NNP cord-015306-us58wwmp 2774 14 were be VBD cord-015306-us58wwmp 2774 15 the the DT cord-015306-us58wwmp 2774 16 only only JJ cord-015306-us58wwmp 2774 17 findings finding NNS cord-015306-us58wwmp 2774 18 of of IN cord-015306-us58wwmp 2774 19 renal renal JJ cord-015306-us58wwmp 2774 20 involvement involvement NN cord-015306-us58wwmp 2774 21 in in IN cord-015306-us58wwmp 2774 22 KD KD NNP cord-015306-us58wwmp 2774 23 . . . cord-015306-us58wwmp 2775 1 However however RB cord-015306-us58wwmp 2775 2 there there EX cord-015306-us58wwmp 2775 3 was be VBD cord-015306-us58wwmp 2775 4 no no DT cord-015306-us58wwmp 2775 5 aggressive aggressive JJ cord-015306-us58wwmp 2775 6 renal renal JJ cord-015306-us58wwmp 2775 7 manifestation manifestation NN cord-015306-us58wwmp 2775 8 which which WDT cord-015306-us58wwmp 2775 9 could could MD cord-015306-us58wwmp 2775 10 be be VB cord-015306-us58wwmp 2775 11 detected detect VBN cord-015306-us58wwmp 2775 12 in in IN cord-015306-us58wwmp 2775 13 DMSA DMSA NNP cord-015306-us58wwmp 2775 14 renal renal JJ cord-015306-us58wwmp 2775 15 SPECT SPECT NNS cord-015306-us58wwmp 2775 16 . . . cord-015306-us58wwmp 2776 1 Objective objective JJ cord-015306-us58wwmp 2776 2 : : : cord-015306-us58wwmp 2776 3 In in IN cord-015306-us58wwmp 2776 4 this this DT cord-015306-us58wwmp 2776 5 study study NN cord-015306-us58wwmp 2776 6 , , , cord-015306-us58wwmp 2776 7 the the DT cord-015306-us58wwmp 2776 8 question question NN cord-015306-us58wwmp 2776 9 remains remain VBZ cord-015306-us58wwmp 2776 10 if if IN cord-015306-us58wwmp 2776 11 NGAL NGAL NNP cord-015306-us58wwmp 2776 12 is be VBZ cord-015306-us58wwmp 2776 13 a a DT cord-015306-us58wwmp 2776 14 culprit culprit NN cord-015306-us58wwmp 2776 15 or or CC cord-015306-us58wwmp 2776 16 only only JJ cord-015306-us58wwmp 2776 17 bystander bystander NN cord-015306-us58wwmp 2776 18 in in IN cord-015306-us58wwmp 2776 19 AKI AKI NNP cord-015306-us58wwmp 2776 20 due due JJ cord-015306-us58wwmp 2776 21 to to IN cord-015306-us58wwmp 2776 22 sepsis sepsis NN cord-015306-us58wwmp 2776 23 in in IN cord-015306-us58wwmp 2776 24 children child NNS cord-015306-us58wwmp 2776 25 . . . cord-015306-us58wwmp 2777 1 Methods method NNS cord-015306-us58wwmp 2777 2 : : : cord-015306-us58wwmp 2777 3 Twenty twenty CD cord-015306-us58wwmp 2777 4 seven seven CD cord-015306-us58wwmp 2777 5 children child NNS cord-015306-us58wwmp 2777 6 , , , cord-015306-us58wwmp 2777 7 ( ( -LRB- cord-015306-us58wwmp 2777 8 M-17 M-17 NNP cord-015306-us58wwmp 2777 9 , , , cord-015306-us58wwmp 2777 10 F-10 F-10 NNP cord-015306-us58wwmp 2777 11 ) ) -RRB- cord-015306-us58wwmp 2777 12 admitted admit VBD cord-015306-us58wwmp 2777 13 to to IN cord-015306-us58wwmp 2777 14 Intensive Intensive NNP cord-015306-us58wwmp 2777 15 Care Care NNP cord-015306-us58wwmp 2777 16 diagnosed diagnose VBN cord-015306-us58wwmp 2777 17 with with IN cord-015306-us58wwmp 2777 18 sepsis sepsis NN cord-015306-us58wwmp 2777 19 , , , cord-015306-us58wwmp 2777 20 severe severe JJ cord-015306-us58wwmp 2777 21 sepsis sepsis NN cord-015306-us58wwmp 2777 22 or or CC cord-015306-us58wwmp 2777 23 septic septic JJ cord-015306-us58wwmp 2777 24 shock shock NN cord-015306-us58wwmp 2777 25 were be VBD cord-015306-us58wwmp 2777 26 enrolled enrol VBN cord-015306-us58wwmp 2777 27 in in IN cord-015306-us58wwmp 2777 28 this this DT cord-015306-us58wwmp 2777 29 study study NN cord-015306-us58wwmp 2777 30 . . . cord-015306-us58wwmp 2778 1 The the DT cord-015306-us58wwmp 2778 2 concentration concentration NN cord-015306-us58wwmp 2778 3 of of IN cord-015306-us58wwmp 2778 4 NGAL NGAL NNP cord-015306-us58wwmp 2778 5 , , , cord-015306-us58wwmp 2778 6 protein protein NN cord-015306-us58wwmp 2778 7 C C NNP cord-015306-us58wwmp 2778 8 and and CC cord-015306-us58wwmp 2778 9 S S NNP cord-015306-us58wwmp 2778 10 , , , cord-015306-us58wwmp 2778 11 Antithrombin Antithrombin NNP cord-015306-us58wwmp 2778 12 III III NNP cord-015306-us58wwmp 2778 13 and and CC cord-015306-us58wwmp 2778 14 basic basic JJ cord-015306-us58wwmp 2778 15 parameters parameter NNS cord-015306-us58wwmp 2778 16 were be VBD cord-015306-us58wwmp 2778 17 measured measure VBN cord-015306-us58wwmp 2778 18 in in IN cord-015306-us58wwmp 2778 19 the the DT cord-015306-us58wwmp 2778 20 plasma plasma NN cord-015306-us58wwmp 2778 21 at at IN cord-015306-us58wwmp 2778 22 diagnosis diagnosis NN cord-015306-us58wwmp 2778 23 and and CC cord-015306-us58wwmp 2778 24 after after IN cord-015306-us58wwmp 2778 25 10 10 CD cord-015306-us58wwmp 2778 26 days day NNS cord-015306-us58wwmp 2778 27 of of IN cord-015306-us58wwmp 2778 28 treatment treatment NN cord-015306-us58wwmp 2778 29 . . . cord-015306-us58wwmp 2779 1 Results result NNS cord-015306-us58wwmp 2779 2 : : : cord-015306-us58wwmp 2780 1 Mean mean JJ cord-015306-us58wwmp 2780 2 creatinine creatinine NN cord-015306-us58wwmp 2780 3 concentration concentration NN cord-015306-us58wwmp 2780 4 in in IN cord-015306-us58wwmp 2780 5 septic septic JJ cord-015306-us58wwmp 2780 6 children child NNS cord-015306-us58wwmp 2780 7 at at IN cord-015306-us58wwmp 2780 8 admission admission NN cord-015306-us58wwmp 2780 9 was be VBD cord-015306-us58wwmp 2780 10 higher high JJR cord-015306-us58wwmp 2780 11 than than IN cord-015306-us58wwmp 2780 12 in in IN cord-015306-us58wwmp 2780 13 reference reference NN cord-015306-us58wwmp 2780 14 group group NN cord-015306-us58wwmp 2780 15 ( ( -LRB- cord-015306-us58wwmp 2780 16 p p NN cord-015306-us58wwmp 2780 17 < < XX cord-015306-us58wwmp 2780 18 0.05 0.05 CD cord-015306-us58wwmp 2780 19 ) ) -RRB- cord-015306-us58wwmp 2780 20 . . . cord-015306-us58wwmp 2781 1 There there EX cord-015306-us58wwmp 2781 2 was be VBD cord-015306-us58wwmp 2781 3 statistically statistically RB cord-015306-us58wwmp 2781 4 significant significant JJ cord-015306-us58wwmp 2781 5 difference difference NN cord-015306-us58wwmp 2781 6 in in IN cord-015306-us58wwmp 2781 7 APTT APTT NNP cord-015306-us58wwmp 2781 8 , , , cord-015306-us58wwmp 2781 9 prothrombin prothrombin JJ cord-015306-us58wwmp 2781 10 time time NN cord-015306-us58wwmp 2781 11 , , , cord-015306-us58wwmp 2781 12 prothrombin prothrombin NN cord-015306-us58wwmp 2781 13 ratio ratio NN cord-015306-us58wwmp 2781 14 , , , cord-015306-us58wwmp 2781 15 thrombocytes thrombocyte NNS cord-015306-us58wwmp 2781 16 count count NN cord-015306-us58wwmp 2781 17 , , , cord-015306-us58wwmp 2781 18 heart heart NN cord-015306-us58wwmp 2781 19 rate rate NN cord-015306-us58wwmp 2781 20 , , , cord-015306-us58wwmp 2781 21 and and CC cord-015306-us58wwmp 2781 22 systolic systolic JJ cord-015306-us58wwmp 2781 23 blood blood NN cord-015306-us58wwmp 2781 24 pressure pressure NN cord-015306-us58wwmp 2781 25 between between IN cord-015306-us58wwmp 2781 26 study study NN cord-015306-us58wwmp 2781 27 groups group NNS cord-015306-us58wwmp 2781 28 in in IN cord-015306-us58wwmp 2781 29 first first JJ cord-015306-us58wwmp 2781 30 and and CC cord-015306-us58wwmp 2781 31 after after IN cord-015306-us58wwmp 2781 32 10 10 CD cord-015306-us58wwmp 2781 33 days day NNS cord-015306-us58wwmp 2782 1 ( ( -LRB- cord-015306-us58wwmp 2782 2 p<0.005 p<0.005 JJ cord-015306-us58wwmp 2782 3 , , , cord-015306-us58wwmp 2782 4 p<0.001 p<0.001 CD cord-015306-us58wwmp 2782 5 , , , cord-015306-us58wwmp 2782 6 p<0.001 p<0.001 CD cord-015306-us58wwmp 2782 7 , , , cord-015306-us58wwmp 2782 8 p<0.01 p<0.01 NNP cord-015306-us58wwmp 2782 9 , , , cord-015306-us58wwmp 2782 10 p<0.05 p<0.05 CD cord-015306-us58wwmp 2782 11 , , , cord-015306-us58wwmp 2782 12 p<0.05 p<0.05 JJ cord-015306-us58wwmp 2782 13 respectively respectively RB cord-015306-us58wwmp 2782 14 ) ) -RRB- cord-015306-us58wwmp 2782 15 . . . cord-015306-us58wwmp 2783 1 The the DT cord-015306-us58wwmp 2783 2 PC pc NN cord-015306-us58wwmp 2783 3 concentration concentration NN cord-015306-us58wwmp 2783 4 in in IN cord-015306-us58wwmp 2783 5 the the DT cord-015306-us58wwmp 2783 6 septic septic JJ cord-015306-us58wwmp 2783 7 patients patient NNS cord-015306-us58wwmp 2783 8 was be VBD cord-015306-us58wwmp 2783 9 significantly significantly RB cord-015306-us58wwmp 2783 10 lower low JJR cord-015306-us58wwmp 2783 11 than than IN cord-015306-us58wwmp 2783 12 those those DT cord-015306-us58wwmp 2783 13 of of IN cord-015306-us58wwmp 2783 14 the the DT cord-015306-us58wwmp 2783 15 references reference NNS cord-015306-us58wwmp 2783 16 ( ( -LRB- cord-015306-us58wwmp 2783 17 p<0.0001 p<0.0001 NNP cord-015306-us58wwmp 2783 18 ) ) -RRB- cord-015306-us58wwmp 2783 19 , , , cord-015306-us58wwmp 2783 20 and and CC cord-015306-us58wwmp 2783 21 during during IN cord-015306-us58wwmp 2783 22 intensive intensive JJ cord-015306-us58wwmp 2783 23 10 10 CD cord-015306-us58wwmp 2783 24 days day NNS cord-015306-us58wwmp 2783 25 treatment treatment NN cord-015306-us58wwmp 2783 26 raised raise VBN cord-015306-us58wwmp 2783 27 ( ( -LRB- cord-015306-us58wwmp 2783 28 p<0.01 p<0.01 NNP cord-015306-us58wwmp 2783 29 ) ) -RRB- cord-015306-us58wwmp 2783 30 . . . cord-015306-us58wwmp 2784 1 Also also RB cord-015306-us58wwmp 2784 2 protein protein NN cord-015306-us58wwmp 2784 3 S S NNP cord-015306-us58wwmp 2784 4 concentration concentration NN cord-015306-us58wwmp 2784 5 rose rise VBD cord-015306-us58wwmp 2784 6 during during IN cord-015306-us58wwmp 2784 7 the the DT cord-015306-us58wwmp 2784 8 treatment treatment NN cord-015306-us58wwmp 2784 9 ( ( -LRB- cord-015306-us58wwmp 2784 10 p<0.005 p<0.005 JJ cord-015306-us58wwmp 2784 11 ) ) -RRB- cord-015306-us58wwmp 2784 12 , , , cord-015306-us58wwmp 2784 13 and and CC cord-015306-us58wwmp 2784 14 was be VBD cord-015306-us58wwmp 2784 15 lower low JJR cord-015306-us58wwmp 2784 16 in in IN cord-015306-us58wwmp 2784 17 septic septic JJ cord-015306-us58wwmp 2784 18 children child NNS cord-015306-us58wwmp 2784 19 then then RB cord-015306-us58wwmp 2784 20 reference reference NN cord-015306-us58wwmp 2784 21 group group NN cord-015306-us58wwmp 2784 22 ( ( -LRB- cord-015306-us58wwmp 2784 23 p<0.0001 p<0.0001 NNP cord-015306-us58wwmp 2784 24 ) ) -RRB- cord-015306-us58wwmp 2784 25 . . . cord-015306-us58wwmp 2785 1 NGAL NGAL NNP cord-015306-us58wwmp 2785 2 concentration concentration NN cord-015306-us58wwmp 2785 3 was be VBD cord-015306-us58wwmp 2785 4 significantly significantly RB cord-015306-us58wwmp 2785 5 higher high JJR cord-015306-us58wwmp 2785 6 in in IN cord-015306-us58wwmp 2785 7 study study NN cord-015306-us58wwmp 2785 8 group group NN cord-015306-us58wwmp 2785 9 on on IN cord-015306-us58wwmp 2785 10 the the DT cord-015306-us58wwmp 2785 11 admission admission NN cord-015306-us58wwmp 2785 12 day day NN cord-015306-us58wwmp 2785 13 comparing compare VBG cord-015306-us58wwmp 2785 14 with with IN cord-015306-us58wwmp 2785 15 reference reference NN cord-015306-us58wwmp 2785 16 group group NN cord-015306-us58wwmp 2785 17 ( ( -LRB- cord-015306-us58wwmp 2785 18 p<0.05 p<0.05 CD cord-015306-us58wwmp 2785 19 ) ) -RRB- cord-015306-us58wwmp 2785 20 . . . cord-015306-us58wwmp 2786 1 Plasma Plasma NNP cord-015306-us58wwmp 2786 2 NGAL NGAL NNP cord-015306-us58wwmp 2786 3 was be VBD cord-015306-us58wwmp 2786 4 correlated correlate VBN cord-015306-us58wwmp 2786 5 at at IN cord-015306-us58wwmp 2786 6 admission admission NN cord-015306-us58wwmp 2786 7 and and CC cord-015306-us58wwmp 2786 8 after after IN cord-015306-us58wwmp 2786 9 10 10 CD cord-015306-us58wwmp 2786 10 days day NNS cord-015306-us58wwmp 2786 11 of of IN cord-015306-us58wwmp 2786 12 treatment treatment NN cord-015306-us58wwmp 2786 13 with with IN cord-015306-us58wwmp 2786 14 protein protein NN cord-015306-us58wwmp 2786 15 C C NNP cord-015306-us58wwmp 2786 16 ( ( -LRB- cord-015306-us58wwmp 2786 17 respectively respectively RB cord-015306-us58wwmp 2786 18 : : : cord-015306-us58wwmp 2786 19 r=-0.48 r=-0.48 NNP cord-015306-us58wwmp 2786 20 , , , cord-015306-us58wwmp 2786 21 p<0.00005 p<0.00005 RB cord-015306-us58wwmp 2786 22 ; ; : cord-015306-us58wwmp 2786 23 r=-0.53 r=-0.53 ADD cord-015306-us58wwmp 2786 24 , , , cord-015306-us58wwmp 2786 25 p<0.05 p<0.05 CD cord-015306-us58wwmp 2786 26 ) ) -RRB- cord-015306-us58wwmp 2786 27 . . . cord-015306-us58wwmp 2787 1 Multivariate multivariate JJ cord-015306-us58wwmp 2787 2 regression regression NN cord-015306-us58wwmp 2787 3 revealed reveal VBD cord-015306-us58wwmp 2787 4 that that IN cord-015306-us58wwmp 2787 5 NGAL NGAL NNP cord-015306-us58wwmp 2787 6 was be VBD cord-015306-us58wwmp 2787 7 significantly significantly RB cord-015306-us58wwmp 2787 8 predicted predict VBN cord-015306-us58wwmp 2787 9 by by IN cord-015306-us58wwmp 2787 10 creatinine creatinine NN cord-015306-us58wwmp 2787 11 ( ( -LRB- cord-015306-us58wwmp 2787 12 β=0.39 β=0.39 NNP cord-015306-us58wwmp 2787 13 , , , cord-015306-us58wwmp 2787 14 p<0.01 p<0.01 NNP cord-015306-us58wwmp 2787 15 ) ) -RRB- cord-015306-us58wwmp 2787 16 and and CC cord-015306-us58wwmp 2787 17 Protein Protein NNP cord-015306-us58wwmp 2787 18 C C NNP cord-015306-us58wwmp 2787 19 ( ( -LRB- cord-015306-us58wwmp 2787 20 β=-0.38 β=-0.38 NNP cord-015306-us58wwmp 2787 21 ; ; : cord-015306-us58wwmp 2787 22 p<0.01 p<0.01 NNP cord-015306-us58wwmp 2787 23 ) ) -RRB- cord-015306-us58wwmp 2787 24 , , , cord-015306-us58wwmp 2787 25 yielding yield VBG cord-015306-us58wwmp 2787 26 a a DT cord-015306-us58wwmp 2787 27 model model NN cord-015306-us58wwmp 2787 28 R2 r2 NN cord-015306-us58wwmp 2787 29 = = SYM cord-015306-us58wwmp 2787 30 0.34 0.34 CD cord-015306-us58wwmp 2787 31 ( ( -LRB- cord-015306-us58wwmp 2787 32 p<0.001 p<0.001 CD cord-015306-us58wwmp 2787 33 ) ) -RRB- cord-015306-us58wwmp 2787 34 . . . cord-015306-us58wwmp 2788 1 Conclusions conclusion NNS cord-015306-us58wwmp 2788 2 : : : cord-015306-us58wwmp 2789 1 It -PRON- PRP cord-015306-us58wwmp 2789 2 is be VBZ cord-015306-us58wwmp 2789 3 possible possible JJ cord-015306-us58wwmp 2789 4 that that IN cord-015306-us58wwmp 2789 5 kidney kidney NN cord-015306-us58wwmp 2789 6 binding binding NN cord-015306-us58wwmp 2789 7 of of IN cord-015306-us58wwmp 2789 8 pathogenic pathogenic JJ cord-015306-us58wwmp 2789 9 antibodies antibody NNS cord-015306-us58wwmp 2789 10 stimulates stimulate VBZ cord-015306-us58wwmp 2789 11 local local JJ cord-015306-us58wwmp 2789 12 expression expression NN cord-015306-us58wwmp 2789 13 of of IN cord-015306-us58wwmp 2789 14 NGAL NGAL NNP cord-015306-us58wwmp 2789 15 , , , cord-015306-us58wwmp 2789 16 which which WDT cord-015306-us58wwmp 2789 17 plays play VBZ cord-015306-us58wwmp 2789 18 a a DT cord-015306-us58wwmp 2789 19 crucial crucial JJ cord-015306-us58wwmp 2789 20 role role NN cord-015306-us58wwmp 2789 21 in in IN cord-015306-us58wwmp 2789 22 the the DT cord-015306-us58wwmp 2789 23 pathogenesis pathogenesis NN cord-015306-us58wwmp 2789 24 of of IN cord-015306-us58wwmp 2789 25 AKI AKI NNP cord-015306-us58wwmp 2789 26 . . . cord-015306-us58wwmp 2790 1 Objective objective NN cord-015306-us58wwmp 2790 2 : : : cord-015306-us58wwmp 2791 1 The the DT cord-015306-us58wwmp 2791 2 aim aim NN cord-015306-us58wwmp 2791 3 of of IN cord-015306-us58wwmp 2791 4 the the DT cord-015306-us58wwmp 2791 5 study study NN cord-015306-us58wwmp 2791 6 was be VBD cord-015306-us58wwmp 2791 7 to to TO cord-015306-us58wwmp 2791 8 assess assess VB cord-015306-us58wwmp 2791 9 the the DT cord-015306-us58wwmp 2791 10 impact impact NN cord-015306-us58wwmp 2791 11 of of IN cord-015306-us58wwmp 2791 12 perinatal perinatal JJ cord-015306-us58wwmp 2791 13 risk risk NN cord-015306-us58wwmp 2791 14 factors factor NNS cord-015306-us58wwmp 2791 15 ( ( -LRB- cord-015306-us58wwmp 2791 16 PRFs PRFs NNP cord-015306-us58wwmp 2791 17 ) ) -RRB- cord-015306-us58wwmp 2791 18 on on IN cord-015306-us58wwmp 2791 19 serum serum NN cord-015306-us58wwmp 2791 20 NGAL NGAL NNP cord-015306-us58wwmp 2791 21 level level NN cord-015306-us58wwmp 2791 22 in in IN cord-015306-us58wwmp 2791 23 term term NN cord-015306-us58wwmp 2791 24 neonates neonate NNS cord-015306-us58wwmp 2791 25 . . . cord-015306-us58wwmp 2792 1 Methods method NNS cord-015306-us58wwmp 2792 2 : : : cord-015306-us58wwmp 2792 3 The the DT cord-015306-us58wwmp 2792 4 study study NN cord-015306-us58wwmp 2792 5 group group NN cord-015306-us58wwmp 2792 6 consist consist VBP cord-015306-us58wwmp 2792 7 of of IN cord-015306-us58wwmp 2792 8 62 62 CD cord-015306-us58wwmp 2792 9 term term NN cord-015306-us58wwmp 2792 10 neonates neonate NNS cord-015306-us58wwmp 2792 11 with with IN cord-015306-us58wwmp 2792 12 PRFs prf NNS cord-015306-us58wwmp 2792 13 , , , cord-015306-us58wwmp 2792 14 and and CC cord-015306-us58wwmp 2792 15 14 14 CD cord-015306-us58wwmp 2792 16 healthy healthy JJ cord-015306-us58wwmp 2792 17 neonatescontrol neonatescontrol JJ cord-015306-us58wwmp 2792 18 group group NN cord-015306-us58wwmp 2792 19 ( ( -LRB- cord-015306-us58wwmp 2792 20 CG CG NNP cord-015306-us58wwmp 2792 21 ) ) -RRB- cord-015306-us58wwmp 2792 22 . . . cord-015306-us58wwmp 2793 1 Serum serum NN cord-015306-us58wwmp 2793 2 NGAL NGAL NNP cord-015306-us58wwmp 2793 3 ( ( -LRB- cord-015306-us58wwmp 2793 4 ELISA ELISA NNP cord-015306-us58wwmp 2793 5 ) ) -RRB- cord-015306-us58wwmp 2793 6 was be VBD cord-015306-us58wwmp 2793 7 measured measure VBN cord-015306-us58wwmp 2793 8 in in IN cord-015306-us58wwmp 2793 9 samples sample NNS cord-015306-us58wwmp 2793 10 of of IN cord-015306-us58wwmp 2793 11 cord cord NN cord-015306-us58wwmp 2793 12 blood blood NN cord-015306-us58wwmp 2793 13 ( ( -LRB- cord-015306-us58wwmp 2793 14 cNGAL cngal NN cord-015306-us58wwmp 2793 15 ) ) -RRB- cord-015306-us58wwmp 2793 16 and and CC cord-015306-us58wwmp 2793 17 peripheral peripheral JJ cord-015306-us58wwmp 2793 18 blood blood NN cord-015306-us58wwmp 2793 19 ( ( -LRB- cord-015306-us58wwmp 2793 20 pNGAL pngal NN cord-015306-us58wwmp 2793 21 ) ) -RRB- cord-015306-us58wwmp 2793 22 taken take VBN cord-015306-us58wwmp 2793 23 within within IN cord-015306-us58wwmp 2793 24 first first JJ cord-015306-us58wwmp 2793 25 5 5 CD cord-015306-us58wwmp 2793 26 days day NNS cord-015306-us58wwmp 2793 27 of of IN cord-015306-us58wwmp 2793 28 life life NN cord-015306-us58wwmp 2793 29 , , , cord-015306-us58wwmp 2793 30 and and CC cord-015306-us58wwmp 2793 31 stored store VBN cord-015306-us58wwmp 2793 32 in in IN cord-015306-us58wwmp 2793 33 -80 -80 NNP cord-015306-us58wwmp 2793 34 ° ° NN cord-015306-us58wwmp 2793 35 C C NNP cord-015306-us58wwmp 2793 36 until until IN cord-015306-us58wwmp 2793 37 ELISA ELISA NNP cord-015306-us58wwmp 2793 38 procedure procedure NN cord-015306-us58wwmp 2793 39 was be VBD cord-015306-us58wwmp 2793 40 performed perform VBN cord-015306-us58wwmp 2793 41 . . . cord-015306-us58wwmp 2794 1 PRFs PRFs NNP cord-015306-us58wwmp 2794 2 were be VBD cord-015306-us58wwmp 2794 3 divided divide VBN cord-015306-us58wwmp 2794 4 into into IN cord-015306-us58wwmp 2794 5 3 3 CD cord-015306-us58wwmp 2794 6 groups group NNS cord-015306-us58wwmp 2794 7 : : : cord-015306-us58wwmp 2795 1 1 1 LS cord-015306-us58wwmp 2795 2 . . . cord-015306-us58wwmp 2795 3 pathology pathology NN cord-015306-us58wwmp 2795 4 of of IN cord-015306-us58wwmp 2795 5 pregnancy pregnancy NN cord-015306-us58wwmp 2795 6 or or CC cord-015306-us58wwmp 2795 7 mother mother NN cord-015306-us58wwmp 2795 8 : : : cord-015306-us58wwmp 2795 9 diabetes diabetes NN cord-015306-us58wwmp 2795 10 ( ( -LRB- cord-015306-us58wwmp 2795 11 D d NN cord-015306-us58wwmp 2795 12 ) ) -RRB- cord-015306-us58wwmp 2796 1 n=23 n=23 UH cord-015306-us58wwmp 2796 2 , , , cord-015306-us58wwmp 2796 3 infection infection NN cord-015306-us58wwmp 2796 4 ( ( -LRB- cord-015306-us58wwmp 2796 5 I i NN cord-015306-us58wwmp 2796 6 ) ) -RRB- cord-015306-us58wwmp 2797 1 -elevated -elevated JJ cord-015306-us58wwmp 2797 2 CRP CRP NNP cord-015306-us58wwmp 2797 3 or or CC cord-015306-us58wwmp 2797 4 WBC WBC NNP cord-015306-us58wwmp 2797 5 n=20 n=20 NNP cord-015306-us58wwmp 2797 6 , , , cord-015306-us58wwmp 2797 7 positive positive JJ cord-015306-us58wwmp 2797 8 vaginal vaginal JJ cord-015306-us58wwmp 2797 9 culture culture NN cord-015306-us58wwmp 2797 10 ( ( -LRB- cord-015306-us58wwmp 2797 11 VC VC NNP cord-015306-us58wwmp 2797 12 ) ) -RRB- cord-015306-us58wwmp 2797 13 n=21 n=21 NN cord-015306-us58wwmp 2797 14 , , , cord-015306-us58wwmp 2797 15 hypertension hypertension NN cord-015306-us58wwmp 2797 16 ( ( -LRB- cord-015306-us58wwmp 2797 17 HT HT NNP cord-015306-us58wwmp 2797 18 ) ) -RRB- cord-015306-us58wwmp 2798 1 n=7 n=7 NNS cord-015306-us58wwmp 2798 2 , , , cord-015306-us58wwmp 2798 3 others other NNS cord-015306-us58wwmp 2798 4 n=5 n=5 JJ cord-015306-us58wwmp 2798 5 ; ; : cord-015306-us58wwmp 2798 6 2 2 CD cord-015306-us58wwmp 2798 7 . . . cord-015306-us58wwmp 2799 1 labor labor NN cord-015306-us58wwmp 2799 2 pathology pathology NN cord-015306-us58wwmp 2799 3 : : : cord-015306-us58wwmp 2799 4 instrumental instrumental JJ cord-015306-us58wwmp 2799 5 delivery delivery NN cord-015306-us58wwmp 2799 6 ( ( -LRB- cord-015306-us58wwmp 2799 7 ID ID NNP cord-015306-us58wwmp 2799 8 ) ) -RRB- cord-015306-us58wwmp 2800 1 n=41 n=41 RB cord-015306-us58wwmp 2800 2 , , , cord-015306-us58wwmp 2800 3 premature premature JJ cord-015306-us58wwmp 2800 4 rupture rupture NN cord-015306-us58wwmp 2800 5 of of IN cord-015306-us58wwmp 2800 6 membranes membrane NNS cord-015306-us58wwmp 2800 7 , , , cord-015306-us58wwmp 2800 8 > > XX cord-015306-us58wwmp 2800 9 6 6 CD cord-015306-us58wwmp 2800 10 hours hour NNS cord-015306-us58wwmp 2800 11 ( ( -LRB- cord-015306-us58wwmp 2800 12 PROM prom NN cord-015306-us58wwmp 2800 13 ) ) -RRB- cord-015306-us58wwmp 2801 1 n=26 n=26 RB cord-015306-us58wwmp 2801 2 , , , cord-015306-us58wwmp 2801 3 fetal fetal JJ cord-015306-us58wwmp 2801 4 distress distress NN cord-015306-us58wwmp 2801 5 ( ( -LRB- cord-015306-us58wwmp 2801 6 FD FD NNP cord-015306-us58wwmp 2801 7 ) ) -RRB- cord-015306-us58wwmp 2802 1 n=26 n=26 RB cord-015306-us58wwmp 2802 2 ; ; : cord-015306-us58wwmp 2802 3 3 3 CD cord-015306-us58wwmp 2802 4 . . . cord-015306-us58wwmp 2803 1 neonatal neonatal JJ cord-015306-us58wwmp 2803 2 pathology pathology NN cord-015306-us58wwmp 2803 3 : : : cord-015306-us58wwmp 2804 1 intrauterine intrauterine JJ cord-015306-us58wwmp 2804 2 infection infection NN cord-015306-us58wwmp 2804 3 ( ( -LRB- cord-015306-us58wwmp 2804 4 II II NNP cord-015306-us58wwmp 2804 5 ) ) -RRB- cord-015306-us58wwmp 2804 6 n=10 n=10 NNP cord-015306-us58wwmp 2804 7 , , , cord-015306-us58wwmp 2804 8 CAKUT CAKUT NNP cord-015306-us58wwmp 2804 9 n=5 n=5 RB cord-015306-us58wwmp 2804 10 , , . cord-015306-us58wwmp 2805 1 perinatal perinatal JJ cord-015306-us58wwmp 2805 2 asphyxia asphyxia NN cord-015306-us58wwmp 2805 3 ( ( -LRB- cord-015306-us58wwmp 2805 4 PA PA NNP cord-015306-us58wwmp 2805 5 ) ) -RRB- cord-015306-us58wwmp 2805 6 n=4 n=4 NNS cord-015306-us58wwmp 2805 7 . . . cord-015306-us58wwmp 2806 1 The the DT cord-015306-us58wwmp 2806 2 results result NNS cord-015306-us58wwmp 2806 3 were be VBD cord-015306-us58wwmp 2806 4 shown show VBN cord-015306-us58wwmp 2806 5 as as IN cord-015306-us58wwmp 2806 6 median median NN cord-015306-us58wwmp 2806 7 ; ; : cord-015306-us58wwmp 2806 8 values value NNS cord-015306-us58wwmp 2806 9 of of IN cord-015306-us58wwmp 2806 10 cNGAL cngal NN cord-015306-us58wwmp 2806 11 , , , cord-015306-us58wwmp 2806 12 pNGAL pNGAL NNP cord-015306-us58wwmp 2806 13 were be VBD cord-015306-us58wwmp 2806 14 logtransformed logtransforme VBN cord-015306-us58wwmp 2806 15 before before IN cord-015306-us58wwmp 2806 16 analysis analysis NN cord-015306-us58wwmp 2806 17 . . . cord-015306-us58wwmp 2807 1 Statistical statistical JJ cord-015306-us58wwmp 2807 2 analysis analysis NN cord-015306-us58wwmp 2807 3 was be VBD cord-015306-us58wwmp 2807 4 performed perform VBN cord-015306-us58wwmp 2807 5 with with IN cord-015306-us58wwmp 2807 6 t t NN cord-015306-us58wwmp 2807 7 - - HYPH cord-015306-us58wwmp 2807 8 student student NN cord-015306-us58wwmp 2807 9 , , , cord-015306-us58wwmp 2807 10 MANOVA MANOVA NNP cord-015306-us58wwmp 2807 11 tests test NNS cord-015306-us58wwmp 2807 12 with with IN cord-015306-us58wwmp 2807 13 help help NN cord-015306-us58wwmp 2807 14 of of IN cord-015306-us58wwmp 2807 15 Statistica Statistica NNP cord-015306-us58wwmp 2807 16 10 10 CD cord-015306-us58wwmp 2807 17 . . . cord-015306-us58wwmp 2808 1 Statistical statistical JJ cord-015306-us58wwmp 2808 2 significance significance NN cord-015306-us58wwmp 2808 3 : : : cord-015306-us58wwmp 2809 1 p<0.05 p<0.05 NNP cord-015306-us58wwmp 2809 2 . . . cord-015306-us58wwmp 2810 1 Results result NNS cord-015306-us58wwmp 2810 2 : : : cord-015306-us58wwmp 2811 1 In in IN cord-015306-us58wwmp 2811 2 62 62 CD cord-015306-us58wwmp 2811 3 term term NN cord-015306-us58wwmp 2811 4 neonates neonate NNS cord-015306-us58wwmp 2811 5 , , , cord-015306-us58wwmp 2811 6 median median JJ cord-015306-us58wwmp 2811 7 cNGAL cngal RB cord-015306-us58wwmp 2811 8 was be VBD cord-015306-us58wwmp 2811 9 117.69ng 117.69ng CD cord-015306-us58wwmp 2812 1 /mL /mL . cord-015306-us58wwmp 2813 1 vs vs IN cord-015306-us58wwmp 2813 2 64.37ng 64.37ng CD cord-015306-us58wwmp 2813 3 / / SYM cord-015306-us58wwmp 2813 4 mL ml NN cord-015306-us58wwmp 2813 5 in in IN cord-015306-us58wwmp 2813 6 CG CG NNP cord-015306-us58wwmp 2813 7 . . . cord-015306-us58wwmp 2814 1 Mean mean JJ cord-015306-us58wwmp 2814 2 log log NN cord-015306-us58wwmp 2814 3 cNGAL cngal RB cord-015306-us58wwmp 2814 4 was be VBD cord-015306-us58wwmp 2814 5 significantly significantly RB cord-015306-us58wwmp 2814 6 higher high JJR cord-015306-us58wwmp 2814 7 ( ( -LRB- cord-015306-us58wwmp 2814 8 p<0.01 p<0.01 NN cord-015306-us58wwmp 2814 9 ) ) -RRB- cord-015306-us58wwmp 2815 1 vs vs IN cord-015306-us58wwmp 2815 2 CG CG NNP cord-015306-us58wwmp 2815 3 , , , cord-015306-us58wwmp 2815 4 pNGAL pNGAL NNP cord-015306-us58wwmp 2815 5 was be VBD cord-015306-us58wwmp 2815 6 NS NS NNP cord-015306-us58wwmp 2815 7 . . . cord-015306-us58wwmp 2816 1 Mean mean JJ cord-015306-us58wwmp 2816 2 log log NN cord-015306-us58wwmp 2816 3 cNGAL cngal RB cord-015306-us58wwmp 2816 4 correlated correlate VBN cord-015306-us58wwmp 2816 5 positively positively RB cord-015306-us58wwmp 2816 6 with with IN cord-015306-us58wwmp 2816 7 mean mean JJ cord-015306-us58wwmp 2816 8 log log NN cord-015306-us58wwmp 2816 9 pNGAL pngal NN cord-015306-us58wwmp 2817 1 ( ( -LRB- cord-015306-us58wwmp 2817 2 r=0.36 r=0.36 NNP cord-015306-us58wwmp 2817 3 , , , cord-015306-us58wwmp 2817 4 p<0.01 p<0.01 NNP cord-015306-us58wwmp 2817 5 ) ) -RRB- cord-015306-us58wwmp 2817 6 . . . cord-015306-us58wwmp 2818 1 Univariate Univariate NNP cord-015306-us58wwmp 2818 2 analyzes analyze VBZ cord-015306-us58wwmp 2818 3 of of IN cord-015306-us58wwmp 2818 4 log log NN cord-015306-us58wwmp 2818 5 NGAL NGAL NNP cord-015306-us58wwmp 2818 6 in in IN cord-015306-us58wwmp 2818 7 neonates neonate NNS cord-015306-us58wwmp 2818 8 with with IN cord-015306-us58wwmp 2818 9 chosen choose VBN cord-015306-us58wwmp 2818 10 PRFs prf NNS cord-015306-us58wwmp 2818 11 vs vs IN cord-015306-us58wwmp 2818 12 neonates neonate NNS cord-015306-us58wwmp 2818 13 without without IN cord-015306-us58wwmp 2818 14 particular particular JJ cord-015306-us58wwmp 2818 15 factor factor NN cord-015306-us58wwmp 2818 16 showed show VBD cord-015306-us58wwmp 2818 17 significantly significantly RB cord-015306-us58wwmp 2818 18 higher high JJR cord-015306-us58wwmp 2819 1 ( ( -LRB- cord-015306-us58wwmp 2819 2 p<0.05 p<0.05 CD cord-015306-us58wwmp 2819 3 ) ) -RRB- cord-015306-us58wwmp 2819 4 mean mean VBP cord-015306-us58wwmp 2819 5 log log NN cord-015306-us58wwmp 2819 6 cNGAL cngal RB cord-015306-us58wwmp 2819 7 in in IN cord-015306-us58wwmp 2819 8 ID ID NNP cord-015306-us58wwmp 2819 9 and and CC cord-015306-us58wwmp 2819 10 FD FD NNP cord-015306-us58wwmp 2819 11 group group NN cord-015306-us58wwmp 2820 1 ( ( -LRB- cord-015306-us58wwmp 2820 2 median median JJ cord-015306-us58wwmp 2820 3 cNGAL cngal RB cord-015306-us58wwmp 2820 4 : : : cord-015306-us58wwmp 2820 5 126.47 126.47 CD cord-015306-us58wwmp 2820 6 vs vs IN cord-015306-us58wwmp 2820 7 67.50 67.50 CD cord-015306-us58wwmp 2820 8 and and CC cord-015306-us58wwmp 2820 9 122.30 122.30 CD cord-015306-us58wwmp 2820 10 vs vs IN cord-015306-us58wwmp 2820 11 77.01ng 77.01ng CD cord-015306-us58wwmp 2820 12 / / SYM cord-015306-us58wwmp 2820 13 mL ml NN cord-015306-us58wwmp 2820 14 respectively respectively RB cord-015306-us58wwmp 2820 15 ) ) -RRB- cord-015306-us58wwmp 2820 16 , , , cord-015306-us58wwmp 2820 17 whereas whereas IN cord-015306-us58wwmp 2820 18 in in IN cord-015306-us58wwmp 2820 19 II ii CD cord-015306-us58wwmp 2820 20 group group NN cord-015306-us58wwmp 2820 21 significantly significantly RB cord-015306-us58wwmp 2820 22 higher high JJR cord-015306-us58wwmp 2820 23 were be VBD cord-015306-us58wwmp 2820 24 mean mean JJ cord-015306-us58wwmp 2820 25 log log NN cord-015306-us58wwmp 2820 26 cNGAL cngal RB cord-015306-us58wwmp 2821 1 and and CC cord-015306-us58wwmp 2821 2 mean mean VB cord-015306-us58wwmp 2821 3 log log NN cord-015306-us58wwmp 2821 4 pNGAL pngal NN cord-015306-us58wwmp 2822 1 ( ( -LRB- cord-015306-us58wwmp 2822 2 median median JJ cord-015306-us58wwmp 2822 3 cNGAL cngal RB cord-015306-us58wwmp 2822 4 209.69 209.69 CD cord-015306-us58wwmp 2822 5 vs vs IN cord-015306-us58wwmp 2822 6 96.52ng 96.52ng CD cord-015306-us58wwmp 2822 7 / / SYM cord-015306-us58wwmp 2822 8 mL ml NN cord-015306-us58wwmp 2822 9 , , , cord-015306-us58wwmp 2823 1 pNGAL pngal LS cord-015306-us58wwmp 2823 2 457.35 457.35 CD cord-015306-us58wwmp 2823 3 vs vs IN cord-015306-us58wwmp 2823 4 156.37ng 156.37ng CD cord-015306-us58wwmp 2823 5 / / SYM cord-015306-us58wwmp 2823 6 mL ml NN cord-015306-us58wwmp 2823 7 ) ) -RRB- cord-015306-us58wwmp 2823 8 . . . cord-015306-us58wwmp 2824 1 Multivariate multivariate JJ cord-015306-us58wwmp 2824 2 analysis analysis NN cord-015306-us58wwmp 2824 3 showed show VBD cord-015306-us58wwmp 2824 4 that that IN cord-015306-us58wwmp 2824 5 the the DT cord-015306-us58wwmp 2824 6 impact impact NN cord-015306-us58wwmp 2824 7 of of IN cord-015306-us58wwmp 2824 8 ID ID NNP cord-015306-us58wwmp 2824 9 was be VBD cord-015306-us58wwmp 2824 10 significant significant JJ cord-015306-us58wwmp 2824 11 in in IN cord-015306-us58wwmp 2824 12 groups group NNS cord-015306-us58wwmp 2824 13 : : : cord-015306-us58wwmp 2824 14 D D NNP cord-015306-us58wwmp 2824 15 ( ( -LRB- cord-015306-us58wwmp 2824 16 F=9.84 F=9.84 NNP cord-015306-us58wwmp 2824 17 ; ; : cord-015306-us58wwmp 2824 18 p<0.002 p<0.002 CD cord-015306-us58wwmp 2824 19 ) ) -RRB- cord-015306-us58wwmp 2824 20 , , , cord-015306-us58wwmp 2824 21 I -PRON- PRP cord-015306-us58wwmp 2824 22 ( ( -LRB- cord-015306-us58wwmp 2824 23 F=4.56 F=4.56 NNP cord-015306-us58wwmp 2824 24 ; ; : cord-015306-us58wwmp 2824 25 p<0.04 p<0.04 NN cord-015306-us58wwmp 2824 26 ) ) -RRB- cord-015306-us58wwmp 2824 27 , , , cord-015306-us58wwmp 2824 28 PROM prom NN cord-015306-us58wwmp 2824 29 ( ( -LRB- cord-015306-us58wwmp 2824 30 F=6.01 F=6.01 NNP cord-015306-us58wwmp 2824 31 ; ; : cord-015306-us58wwmp 2824 32 p<0.02 p<0.02 XX cord-015306-us58wwmp 2824 33 ) ) -RRB- cord-015306-us58wwmp 2824 34 and and CC cord-015306-us58wwmp 2824 35 FD FD NNP cord-015306-us58wwmp 2824 36 ( ( -LRB- cord-015306-us58wwmp 2824 37 F=5.36 f=5.36 NN cord-015306-us58wwmp 2824 38 ; ; : cord-015306-us58wwmp 2824 39 p<0.02 p<0.02 XX cord-015306-us58wwmp 2824 40 ) ) -RRB- cord-015306-us58wwmp 2824 41 . . . cord-015306-us58wwmp 2825 1 Conclusion conclusion NN cord-015306-us58wwmp 2825 2 : : : cord-015306-us58wwmp 2825 3 1 1 CD cord-015306-us58wwmp 2825 4 . . . cord-015306-us58wwmp 2826 1 Intrauterine intrauterine JJ cord-015306-us58wwmp 2826 2 infection infection NN cord-015306-us58wwmp 2826 3 may may MD cord-015306-us58wwmp 2826 4 have have VB cord-015306-us58wwmp 2826 5 a a DT cord-015306-us58wwmp 2826 6 significant significant JJ cord-015306-us58wwmp 2826 7 influence influence NN cord-015306-us58wwmp 2826 8 on on IN cord-015306-us58wwmp 2826 9 NGAL NGAL NNP cord-015306-us58wwmp 2826 10 in in IN cord-015306-us58wwmp 2826 11 cord cord NN cord-015306-us58wwmp 2826 12 and and CC cord-015306-us58wwmp 2826 13 peripheral peripheral JJ cord-015306-us58wwmp 2826 14 blood blood NN cord-015306-us58wwmp 2826 15 whereas whereas IN cord-015306-us58wwmp 2826 16 fetal fetal JJ cord-015306-us58wwmp 2826 17 distress distress NN cord-015306-us58wwmp 2826 18 and and CC cord-015306-us58wwmp 2826 19 instrumental instrumental JJ cord-015306-us58wwmp 2826 20 delivery delivery NN cord-015306-us58wwmp 2826 21 only only RB cord-015306-us58wwmp 2826 22 in in IN cord-015306-us58wwmp 2826 23 cord cord NN cord-015306-us58wwmp 2826 24 blood blood NN cord-015306-us58wwmp 2826 25 . . . cord-015306-us58wwmp 2827 1 2 2 LS cord-015306-us58wwmp 2827 2 . . . cord-015306-us58wwmp 2828 1 The the DT cord-015306-us58wwmp 2828 2 instrumental instrumental JJ cord-015306-us58wwmp 2828 3 termination termination NN cord-015306-us58wwmp 2828 4 of of IN cord-015306-us58wwmp 2828 5 pregnancy pregnancy NN cord-015306-us58wwmp 2828 6 has have VBZ cord-015306-us58wwmp 2828 7 an an DT cord-015306-us58wwmp 2828 8 import import NN cord-015306-us58wwmp 2828 9 impact impact NN cord-015306-us58wwmp 2828 10 on on IN cord-015306-us58wwmp 2828 11 NGAL NGAL NNP cord-015306-us58wwmp 2828 12 level level NN cord-015306-us58wwmp 2828 13 in in IN cord-015306-us58wwmp 2828 14 cord cord NN cord-015306-us58wwmp 2828 15 blood blood NN cord-015306-us58wwmp 2828 16 of of IN cord-015306-us58wwmp 2828 17 neonates neonate NNS cord-015306-us58wwmp 2828 18 whose whose WP$ cord-015306-us58wwmp 2828 19 mothers mother NNS cord-015306-us58wwmp 2828 20 had have VBD cord-015306-us58wwmp 2828 21 diabetes diabete NNS cord-015306-us58wwmp 2828 22 or or CC cord-015306-us58wwmp 2828 23 infection infection NN cord-015306-us58wwmp 2828 24 , , , cord-015306-us58wwmp 2828 25 with with IN cord-015306-us58wwmp 2828 26 PROM prom NN cord-015306-us58wwmp 2828 27 or or CC cord-015306-us58wwmp 2828 28 fetal fetal JJ cord-015306-us58wwmp 2828 29 distress distress NN cord-015306-us58wwmp 2828 30 . . . cord-015306-us58wwmp 2829 1 Objective objective NN cord-015306-us58wwmp 2829 2 : : : cord-015306-us58wwmp 2830 1 Acute acute JJ cord-015306-us58wwmp 2830 2 kidney kidney NN cord-015306-us58wwmp 2830 3 injury injury NN cord-015306-us58wwmp 2830 4 ( ( -LRB- cord-015306-us58wwmp 2830 5 AKI AKI NNP cord-015306-us58wwmp 2830 6 ) ) -RRB- cord-015306-us58wwmp 2830 7 is be VBZ cord-015306-us58wwmp 2830 8 a a DT cord-015306-us58wwmp 2830 9 common common JJ cord-015306-us58wwmp 2830 10 problem problem NN cord-015306-us58wwmp 2830 11 and and CC cord-015306-us58wwmp 2830 12 associated associate VBN cord-015306-us58wwmp 2830 13 with with IN cord-015306-us58wwmp 2830 14 significant significant JJ cord-015306-us58wwmp 2830 15 morbidity morbidity NN cord-015306-us58wwmp 2830 16 and and CC cord-015306-us58wwmp 2830 17 mortality mortality NN cord-015306-us58wwmp 2830 18 in in IN cord-015306-us58wwmp 2830 19 neonates neonate NNS cord-015306-us58wwmp 2830 20 . . . cord-015306-us58wwmp 2831 1 Pediatric pediatric NN cord-015306-us58wwmp 2831 2 - - HYPH cord-015306-us58wwmp 2831 3 modified modify VBN cord-015306-us58wwmp 2831 4 RIFLE RIFLE NNP cord-015306-us58wwmp 2831 5 ( ( -LRB- cord-015306-us58wwmp 2831 6 pRIFLE prifle NN cord-015306-us58wwmp 2831 7 ) ) -RRB- cord-015306-us58wwmp 2831 8 classification classification NN cord-015306-us58wwmp 2831 9 system system NN cord-015306-us58wwmp 2831 10 was be VBD cord-015306-us58wwmp 2831 11 developed develop VBN cord-015306-us58wwmp 2831 12 to to TO cord-015306-us58wwmp 2831 13 standardize standardize VB cord-015306-us58wwmp 2831 14 the the DT cord-015306-us58wwmp 2831 15 definition definition NN cord-015306-us58wwmp 2831 16 of of IN cord-015306-us58wwmp 2831 17 AKI AKI NNP cord-015306-us58wwmp 2831 18 in in IN cord-015306-us58wwmp 2831 19 children child NNS cord-015306-us58wwmp 2831 20 . . . cord-015306-us58wwmp 2832 1 We -PRON- PRP cord-015306-us58wwmp 2832 2 aimed aim VBD cord-015306-us58wwmp 2832 3 to to TO cord-015306-us58wwmp 2832 4 evaluate evaluate VB cord-015306-us58wwmp 2832 5 the the DT cord-015306-us58wwmp 2832 6 performance performance NN cord-015306-us58wwmp 2832 7 of of IN cord-015306-us58wwmp 2832 8 pRIFLE prifle JJ cord-015306-us58wwmp 2832 9 score score NN cord-015306-us58wwmp 2832 10 diagnosis diagnosis NN cord-015306-us58wwmp 2832 11 , , , cord-015306-us58wwmp 2832 12 severity severity NN cord-015306-us58wwmp 2832 13 and and CC cord-015306-us58wwmp 2832 14 prognosis prognosis NN cord-015306-us58wwmp 2832 15 of of IN cord-015306-us58wwmp 2832 16 AKI AKI NNP cord-015306-us58wwmp 2832 17 in in IN cord-015306-us58wwmp 2832 18 term term NN cord-015306-us58wwmp 2832 19 and and CC cord-015306-us58wwmp 2832 20 preterm preterm JJ cord-015306-us58wwmp 2832 21 neonates neonate NNS cord-015306-us58wwmp 2832 22 . . . cord-015306-us58wwmp 2833 1 Methods method NNS cord-015306-us58wwmp 2833 2 : : : cord-015306-us58wwmp 2833 3 In in IN cord-015306-us58wwmp 2833 4 this this DT cord-015306-us58wwmp 2833 5 retrospective retrospective JJ cord-015306-us58wwmp 2833 6 study study NN cord-015306-us58wwmp 2833 7 , , , cord-015306-us58wwmp 2833 8 charts chart NNS cord-015306-us58wwmp 2833 9 of of IN cord-015306-us58wwmp 2833 10 820 820 CD cord-015306-us58wwmp 2833 11 patients patient NNS cord-015306-us58wwmp 2833 12 who who WP cord-015306-us58wwmp 2833 13 were be VBD cord-015306-us58wwmp 2833 14 admitted admit VBN cord-015306-us58wwmp 2833 15 to to IN cord-015306-us58wwmp 2833 16 neonatal neonatal JJ cord-015306-us58wwmp 2833 17 intensive intensive JJ cord-015306-us58wwmp 2833 18 care care NN cord-015306-us58wwmp 2833 19 unit unit NN cord-015306-us58wwmp 2833 20 ( ( -LRB- cord-015306-us58wwmp 2833 21 NICU NICU NNP cord-015306-us58wwmp 2833 22 ) ) -RRB- cord-015306-us58wwmp 2833 23 over over IN cord-015306-us58wwmp 2833 24 a a DT cord-015306-us58wwmp 2833 25 4 4 CD cord-015306-us58wwmp 2833 26 year year NN cord-015306-us58wwmp 2833 27 period period NN cord-015306-us58wwmp 2833 28 were be VBD cord-015306-us58wwmp 2833 29 reviewed review VBN cord-015306-us58wwmp 2833 30 for for IN cord-015306-us58wwmp 2833 31 development development NN cord-015306-us58wwmp 2833 32 of of IN cord-015306-us58wwmp 2833 33 AKI AKI NNP cord-015306-us58wwmp 2833 34 . . . cord-015306-us58wwmp 2834 1 A a DT cord-015306-us58wwmp 2834 2 diagnosis diagnosis NN cord-015306-us58wwmp 2834 3 of of IN cord-015306-us58wwmp 2834 4 AKI AKI NNP cord-015306-us58wwmp 2834 5 was be VBD cord-015306-us58wwmp 2834 6 determined determine VBN cord-015306-us58wwmp 2834 7 for for IN cord-015306-us58wwmp 2834 8 254 254 CD cord-015306-us58wwmp 2834 9 patients patient NNS cord-015306-us58wwmp 2834 10 ( ( -LRB- cord-015306-us58wwmp 2834 11 30.9 30.9 CD cord-015306-us58wwmp 2834 12 % % NN cord-015306-us58wwmp 2834 13 ) ) -RRB- cord-015306-us58wwmp 2834 14 according accord VBG cord-015306-us58wwmp 2834 15 to to IN cord-015306-us58wwmp 2834 16 the the DT cord-015306-us58wwmp 2834 17 pRIFLE prifle JJ cord-015306-us58wwmp 2834 18 criteria criterion NNS cord-015306-us58wwmp 2834 19 Results result NNS cord-015306-us58wwmp 2834 20 : : : cord-015306-us58wwmp 2834 21 Of of IN cord-015306-us58wwmp 2834 22 the the DT cord-015306-us58wwmp 2834 23 254patients 254patients CD cord-015306-us58wwmp 2834 24 included include VBN cord-015306-us58wwmp 2834 25 in in IN cord-015306-us58wwmp 2834 26 this this DT cord-015306-us58wwmp 2834 27 study study NN cord-015306-us58wwmp 2834 28 , , , cord-015306-us58wwmp 2834 29 101 101 CD cord-015306-us58wwmp 2834 30 of of IN cord-015306-us58wwmp 2834 31 them -PRON- PRP cord-015306-us58wwmp 2834 32 were be VBD cord-015306-us58wwmp 2834 33 girls girl NNS cord-015306-us58wwmp 2834 34 and and CC cord-015306-us58wwmp 2834 35 153-were 153-were CD cord-015306-us58wwmp 2834 36 boys boy NNS cord-015306-us58wwmp 2834 37 . . . cord-015306-us58wwmp 2835 1 Mean mean JJ cord-015306-us58wwmp 2835 2 age age NN cord-015306-us58wwmp 2835 3 was be VBD cord-015306-us58wwmp 2835 4 4.12days 4.12days CD cord-015306-us58wwmp 2835 5 ( ( -LRB- cord-015306-us58wwmp 2835 6 min min NNP cord-015306-us58wwmp 2835 7 - - HYPH cord-015306-us58wwmp 2835 8 max max NN cord-015306-us58wwmp 2835 9 : : : cord-015306-us58wwmp 2835 10 0 0 CD cord-015306-us58wwmp 2835 11 - - SYM cord-015306-us58wwmp 2835 12 49 49 CD cord-015306-us58wwmp 2835 13 ) ) -RRB- cord-015306-us58wwmp 2835 14 , , , cord-015306-us58wwmp 2835 15 mean mean JJ cord-015306-us58wwmp 2835 16 birth birth NN cord-015306-us58wwmp 2835 17 week week NN cord-015306-us58wwmp 2835 18 was be VBD cord-015306-us58wwmp 2835 19 33.6 33.6 CD cord-015306-us58wwmp 2835 20 ±5.1 ±5.1 NNP cord-015306-us58wwmp 2835 21 weeks week NNS cord-015306-us58wwmp 2835 22 ( ( -LRB- cord-015306-us58wwmp 2835 23 min min NNP cord-015306-us58wwmp 2835 24 - - HYPH cord-015306-us58wwmp 2835 25 max max NN cord-015306-us58wwmp 2835 26 : : : cord-015306-us58wwmp 2835 27 24 24 CD cord-015306-us58wwmp 2835 28 - - SYM cord-015306-us58wwmp 2835 29 42 42 CD cord-015306-us58wwmp 2835 30 ) ) -RRB- cord-015306-us58wwmp 2835 31 , , , cord-015306-us58wwmp 2835 32 mean mean VB cord-015306-us58wwmp 2835 33 birth birth NN cord-015306-us58wwmp 2835 34 weight weight NN cord-015306-us58wwmp 2835 35 was be VBD cord-015306-us58wwmp 2835 36 2166 2166 CD cord-015306-us58wwmp 2835 37 ± ± NNP cord-015306-us58wwmp 2835 38 1045 1045 CD cord-015306-us58wwmp 2835 39 gr gr NNP cord-015306-us58wwmp 2835 40 ( ( -LRB- cord-015306-us58wwmp 2835 41 min min NNP cord-015306-us58wwmp 2835 42 - - HYPH cord-015306-us58wwmp 2835 43 max max NN cord-015306-us58wwmp 2835 44 : : : cord-015306-us58wwmp 2835 45 580 580 CD cord-015306-us58wwmp 2835 46 - - HYPH cord-015306-us58wwmp 2835 47 4600 4600 CD cord-015306-us58wwmp 2835 48 gr gr NNP cord-015306-us58wwmp 2835 49 ) ) -RRB- cord-015306-us58wwmp 2835 50 , , , cord-015306-us58wwmp 2835 51 length length NN cord-015306-us58wwmp 2835 52 of of IN cord-015306-us58wwmp 2835 53 NICU NICU NNP cord-015306-us58wwmp 2835 54 stay stay NN cord-015306-us58wwmp 2835 55 was be VBD cord-015306-us58wwmp 2835 56 37.3 37.3 CD cord-015306-us58wwmp 2836 1 ± ± NNP cord-015306-us58wwmp 2836 2 33.5(min 33.5(min CD cord-015306-us58wwmp 2836 3 - - HYPH cord-015306-us58wwmp 2836 4 max max NN cord-015306-us58wwmp 2836 5 : : : cord-015306-us58wwmp 2836 6 2 2 CD cord-015306-us58wwmp 2836 7 - - HYPH cord-015306-us58wwmp 2836 8 165days 165days CD cord-015306-us58wwmp 2836 9 ) ) -RRB- cord-015306-us58wwmp 2836 10 . . . cord-015306-us58wwmp 2837 1 Two two CD cord-015306-us58wwmp 2837 2 hundred hundred CD cord-015306-us58wwmp 2837 3 fifty fifty CD cord-015306-us58wwmp 2837 4 four four CD cord-015306-us58wwmp 2837 5 patients patient NNS cord-015306-us58wwmp 2837 6 with with IN cord-015306-us58wwmp 2837 7 AKI AKI NNP cord-015306-us58wwmp 2837 8 were be VBD cord-015306-us58wwmp 2837 9 classified classify VBN cord-015306-us58wwmp 2837 10 according accord VBG cord-015306-us58wwmp 2837 11 to to IN cord-015306-us58wwmp 2837 12 pRIFLE pRIFLE NNP cord-015306-us58wwmp 2837 13 criteria criterion NNS cord-015306-us58wwmp 2837 14 . . . cord-015306-us58wwmp 2838 1 Ninetyeight Ninetyeight NNP cord-015306-us58wwmp 2838 2 patients patient NNS cord-015306-us58wwmp 2838 3 ( ( -LRB- cord-015306-us58wwmp 2838 4 38.5 38.5 CD cord-015306-us58wwmp 2838 5 % % NN cord-015306-us58wwmp 2838 6 ) ) -RRB- cord-015306-us58wwmp 2838 7 achieved achieve VBD cord-015306-us58wwmp 2838 8 an an DT cord-015306-us58wwmp 2838 9 ' ' `` cord-015306-us58wwmp 2838 10 R r NN cord-015306-us58wwmp 2838 11 ' ' '' cord-015306-us58wwmp 2838 12 level level NN cord-015306-us58wwmp 2838 13 of of IN cord-015306-us58wwmp 2838 14 AKI AKI NNP cord-015306-us58wwmp 2838 15 severity severity NN cord-015306-us58wwmp 2838 16 , , , cord-015306-us58wwmp 2838 17 86 86 CD cord-015306-us58wwmp 2838 18 patients patient NNS cord-015306-us58wwmp 2838 19 ( ( -LRB- cord-015306-us58wwmp 2838 20 33.5 33.5 CD cord-015306-us58wwmp 2838 21 % % NN cord-015306-us58wwmp 2838 22 ) ) -RRB- cord-015306-us58wwmp 2838 23 an an DT cord-015306-us58wwmp 2838 24 " " `` cord-015306-us58wwmp 2838 25 I I NNP cord-015306-us58wwmp 2838 26 " " '' cord-015306-us58wwmp 2838 27 level level NN cord-015306-us58wwmp 2838 28 , , , cord-015306-us58wwmp 2838 29 66 66 CD cord-015306-us58wwmp 2838 30 patients patient NNS cord-015306-us58wwmp 2838 31 ( ( -LRB- cord-015306-us58wwmp 2838 32 26 26 CD cord-015306-us58wwmp 2838 33 % % NN cord-015306-us58wwmp 2838 34 ) ) -RRB- cord-015306-us58wwmp 2838 35 an an DT cord-015306-us58wwmp 2838 36 " " `` cord-015306-us58wwmp 2838 37 F F NNP cord-015306-us58wwmp 2838 38 " " '' cord-015306-us58wwmp 2838 39 level level NN cord-015306-us58wwmp 2838 40 , , , cord-015306-us58wwmp 2838 41 4 4 CD cord-015306-us58wwmp 2838 42 patients patient NNS cord-015306-us58wwmp 2838 43 ( ( -LRB- cord-015306-us58wwmp 2838 44 1,5 1,5 CD cord-015306-us58wwmp 2838 45 % % NN cord-015306-us58wwmp 2838 46 ) ) -RRB- cord-015306-us58wwmp 2838 47 an an DT cord-015306-us58wwmp 2838 48 " " `` cord-015306-us58wwmp 2838 49 L l NN cord-015306-us58wwmp 2838 50 " " '' cord-015306-us58wwmp 2838 51 level level NN cord-015306-us58wwmp 2838 52 . . . cord-015306-us58wwmp 2839 1 The the DT cord-015306-us58wwmp 2839 2 most most RBS cord-015306-us58wwmp 2839 3 common common JJ cord-015306-us58wwmp 2839 4 etiologies etiology NNS cord-015306-us58wwmp 2839 5 of of IN cord-015306-us58wwmp 2839 6 AKI AKI NNP cord-015306-us58wwmp 2839 7 -were -were RBR cord-015306-us58wwmp 2839 8 prematurity prematurity NN cord-015306-us58wwmp 2839 9 , , , cord-015306-us58wwmp 2839 10 congenital congenital JJ cord-015306-us58wwmp 2839 11 heart heart NN cord-015306-us58wwmp 2839 12 disease disease NN cord-015306-us58wwmp 2839 13 , , , cord-015306-us58wwmp 2839 14 hypoxic hypoxic JJ cord-015306-us58wwmp 2839 15 ischemic ischemic JJ cord-015306-us58wwmp 2839 16 injury injury NN cord-015306-us58wwmp 2839 17 , , , cord-015306-us58wwmp 2839 18 sepsis sepsis NN cord-015306-us58wwmp 2839 19 and and CC cord-015306-us58wwmp 2839 20 usage usage NN cord-015306-us58wwmp 2839 21 of of IN cord-015306-us58wwmp 2839 22 nephrotoxic nephrotoxic NNP cord-015306-us58wwmp 2839 23 agents agent NNS cord-015306-us58wwmp 2839 24 . . . cord-015306-us58wwmp 2840 1 Patients patient NNS cord-015306-us58wwmp 2840 2 classified classify VBN cord-015306-us58wwmp 2840 3 with with IN cord-015306-us58wwmp 2840 4 a a DT cord-015306-us58wwmp 2840 5 higher high JJR cord-015306-us58wwmp 2840 6 pRIFLE prifle NN cord-015306-us58wwmp 2840 7 score score NN cord-015306-us58wwmp 2841 1 had have VBD cord-015306-us58wwmp 2841 2 a a DT cord-015306-us58wwmp 2841 3 longer long JJR cord-015306-us58wwmp 2841 4 NICU NICU NNP cord-015306-us58wwmp 2841 5 stay stay NN cord-015306-us58wwmp 2841 6 and and CC cord-015306-us58wwmp 2841 7 required require VBD cord-015306-us58wwmp 2841 8 a a DT cord-015306-us58wwmp 2841 9 greater great JJR cord-015306-us58wwmp 2841 10 number number NN cord-015306-us58wwmp 2841 11 of of IN cord-015306-us58wwmp 2841 12 mechanical mechanical JJ cord-015306-us58wwmp 2841 13 ventilation ventilation NN cord-015306-us58wwmp 2841 14 ( ( -LRB- cord-015306-us58wwmp 2841 15 p<0.05 p<0.05 CD cord-015306-us58wwmp 2841 16 ) ) -RRB- cord-015306-us58wwmp 2841 17 . . . cord-015306-us58wwmp 2842 1 Renal renal JJ cord-015306-us58wwmp 2842 2 replacement replacement NN cord-015306-us58wwmp 2842 3 therapy therapy NN cord-015306-us58wwmp 2842 4 ( ( -LRB- cord-015306-us58wwmp 2842 5 RRT rrt NN cord-015306-us58wwmp 2842 6 ) ) -RRB- cord-015306-us58wwmp 2842 7 was be VBD cord-015306-us58wwmp 2842 8 needed need VBN cord-015306-us58wwmp 2842 9 for for IN cord-015306-us58wwmp 2842 10 30 30 CD cord-015306-us58wwmp 2842 11 patients patient NNS cord-015306-us58wwmp 2842 12 ( ( -LRB- cord-015306-us58wwmp 2842 13 11.8 11.8 CD cord-015306-us58wwmp 2842 14 % % NN cord-015306-us58wwmp 2842 15 ) ) -RRB- cord-015306-us58wwmp 2842 16 . . . cord-015306-us58wwmp 2843 1 Mortality mortality NN cord-015306-us58wwmp 2843 2 rate rate NN cord-015306-us58wwmp 2843 3 was be VBD cord-015306-us58wwmp 2843 4 26 26 CD cord-015306-us58wwmp 2843 5 % % NN cord-015306-us58wwmp 2843 6 and and CC cord-015306-us58wwmp 2843 7 all all DT cord-015306-us58wwmp 2843 8 deceased deceased JJ cord-015306-us58wwmp 2843 9 patients patient NNS cord-015306-us58wwmp 2843 10 were be VBD cord-015306-us58wwmp 2843 11 classified classify VBN cord-015306-us58wwmp 2843 12 as as IN cord-015306-us58wwmp 2843 13 pRIFLE pRIFLE VBZ cord-015306-us58wwmp 2843 14 ' ' `` cord-015306-us58wwmp 2843 15 I','F I','F -LRB- cord-015306-us58wwmp 2843 16 ' ' '' cord-015306-us58wwmp 2843 17 or or CC cord-015306-us58wwmp 2843 18 ' ' `` cord-015306-us58wwmp 2843 19 L',p l',p XX cord-015306-us58wwmp 2843 20 < < XX cord-015306-us58wwmp 2843 21 0.05 0.05 CD cord-015306-us58wwmp 2843 22 ) ) -RRB- cord-015306-us58wwmp 2844 1 Conclusion conclusion NN cord-015306-us58wwmp 2844 2 : : : cord-015306-us58wwmp 2844 3 Using use VBG cord-015306-us58wwmp 2844 4 pRIFLE prifle JJ cord-015306-us58wwmp 2844 5 criteria criterion NNS cord-015306-us58wwmp 2844 6 in in IN cord-015306-us58wwmp 2844 7 neonates neonate NNS cord-015306-us58wwmp 2844 8 with with IN cord-015306-us58wwmp 2844 9 AKI AKI NNP cord-015306-us58wwmp 2844 10 is be VBZ cord-015306-us58wwmp 2844 11 an an DT cord-015306-us58wwmp 2844 12 efficient efficient JJ cord-015306-us58wwmp 2844 13 way way NN cord-015306-us58wwmp 2844 14 to to TO cord-015306-us58wwmp 2844 15 assess assess VB cord-015306-us58wwmp 2844 16 the the DT cord-015306-us58wwmp 2844 17 severity severity NN cord-015306-us58wwmp 2844 18 and and CC cord-015306-us58wwmp 2844 19 prognosis prognosis NN cord-015306-us58wwmp 2844 20 of of IN cord-015306-us58wwmp 2844 21 the the DT cord-015306-us58wwmp 2844 22 disease disease NN cord-015306-us58wwmp 2844 23 . . . cord-015306-us58wwmp 2845 1 Objective objective JJ cord-015306-us58wwmp 2845 2 , , , cord-015306-us58wwmp 2845 3 Methods Methods NNPS cord-015306-us58wwmp 2845 4 and and CC cord-015306-us58wwmp 2845 5 Results result NNS cord-015306-us58wwmp 2846 1 : : : cord-015306-us58wwmp 2846 2 I -PRON- PRP cord-015306-us58wwmp 2846 3 present present VBP cord-015306-us58wwmp 2846 4 a a DT cord-015306-us58wwmp 2846 5 case case NN cord-015306-us58wwmp 2846 6 of of IN cord-015306-us58wwmp 2846 7 a a DT cord-015306-us58wwmp 2846 8 11 11 CD cord-015306-us58wwmp 2846 9 years year NNS cord-015306-us58wwmp 2846 10 albanian albanian JJ cord-015306-us58wwmp 2846 11 old old JJ cord-015306-us58wwmp 2846 12 boy boy NN cord-015306-us58wwmp 2846 13 , , , cord-015306-us58wwmp 2846 14 25th 25th JJ cord-015306-us58wwmp 2846 15 centile centile NN cord-015306-us58wwmp 2846 16 of of IN cord-015306-us58wwmp 2846 17 development development NN cord-015306-us58wwmp 2846 18 . . . cord-015306-us58wwmp 2847 1 Presented present VBN cord-015306-us58wwmp 2847 2 with with IN cord-015306-us58wwmp 2847 3 abdominal abdominal JJ cord-015306-us58wwmp 2847 4 pain pain NN cord-015306-us58wwmp 2847 5 , , , cord-015306-us58wwmp 2847 6 vomiting vomit VBG cord-015306-us58wwmp 2847 7 . . . cord-015306-us58wwmp 2848 1 Four four CD cord-015306-us58wwmp 2848 2 days day NNS cord-015306-us58wwmp 2848 3 after after RB cord-015306-us58wwmp 2848 4 , , , cord-015306-us58wwmp 2848 5 was be VBD cord-015306-us58wwmp 2848 6 addmited addmite VBN cord-015306-us58wwmp 2848 7 in in IN cord-015306-us58wwmp 2848 8 the the DT cord-015306-us58wwmp 2848 9 surgery surgery NN cord-015306-us58wwmp 2848 10 clinic clinic NN cord-015306-us58wwmp 2848 11 for for IN cord-015306-us58wwmp 2848 12 uregent uregent NNP cord-015306-us58wwmp 2848 13 apendicitectomy apendicitectomy NNP cord-015306-us58wwmp 2848 14 . . . cord-015306-us58wwmp 2849 1 WBC WBC NNP cord-015306-us58wwmp 2849 2 : : : cord-015306-us58wwmp 2849 3 23.0 23.0 CD cord-015306-us58wwmp 2849 4 , , , cord-015306-us58wwmp 2849 5 SE SE NNP cord-015306-us58wwmp 2849 6 : : : cord-015306-us58wwmp 2849 7 64/ 64/ CD cord-015306-us58wwmp 2849 8 , , , cord-015306-us58wwmp 2849 9 BUN bun NN cord-015306-us58wwmp 2849 10 : : : cord-015306-us58wwmp 2849 11 6.1 6.1 CD cord-015306-us58wwmp 2849 12 , , , cord-015306-us58wwmp 2849 13 Cre Cre NNP cord-015306-us58wwmp 2849 14 : : : cord-015306-us58wwmp 2849 15 60 60 CD cord-015306-us58wwmp 2849 16 , , , cord-015306-us58wwmp 2849 17 urine urine NN cord-015306-us58wwmp 2849 18 : : : cord-015306-us58wwmp 2849 19 normal normal JJ cord-015306-us58wwmp 2849 20 . . . cord-015306-us58wwmp 2850 1 After after IN cord-015306-us58wwmp 2850 2 the the DT cord-015306-us58wwmp 2850 3 intervention intervention NN cord-015306-us58wwmp 2850 4 medications medication NNS cord-015306-us58wwmp 2850 5 that that WDT cord-015306-us58wwmp 2850 6 were be VBD cord-015306-us58wwmp 2850 7 used use VBN cord-015306-us58wwmp 2850 8 were be VBD cord-015306-us58wwmp 2850 9 : : : cord-015306-us58wwmp 2850 10 Gentamycin Gentamycin NNP cord-015306-us58wwmp 2850 11 , , , cord-015306-us58wwmp 2850 12 Metronidazol Metronidazol NNP cord-015306-us58wwmp 2850 13 , , , cord-015306-us58wwmp 2850 14 Cephtriaxon Cephtriaxon NNP cord-015306-us58wwmp 2850 15 , , , cord-015306-us58wwmp 2850 16 H2 H2 NNP cord-015306-us58wwmp 2850 17 blocators blocator NNS cord-015306-us58wwmp 2850 18 . . . cord-015306-us58wwmp 2851 1 Two two CD cord-015306-us58wwmp 2851 2 days day NNS cord-015306-us58wwmp 2851 3 after after IN cord-015306-us58wwmp 2851 4 he -PRON- PRP cord-015306-us58wwmp 2851 5 was be VBD cord-015306-us58wwmp 2851 6 better well JJR cord-015306-us58wwmp 2851 7 . . . cord-015306-us58wwmp 2852 1 Thereafter thereafter RB cord-015306-us58wwmp 2852 2 he -PRON- PRP cord-015306-us58wwmp 2852 3 had have VBD cord-015306-us58wwmp 2852 4 polyuria polyuria NNS cord-015306-us58wwmp 2852 5 and and CC cord-015306-us58wwmp 2852 6 frequent frequent JJ cord-015306-us58wwmp 2852 7 urinating urinating NN cord-015306-us58wwmp 2852 8 . . . cord-015306-us58wwmp 2853 1 The the DT cord-015306-us58wwmp 2853 2 fifth fifth JJ cord-015306-us58wwmp 2853 3 day day NN cord-015306-us58wwmp 2853 4 he -PRON- PRP cord-015306-us58wwmp 2853 5 had have VBD cord-015306-us58wwmp 2853 6 oliguria oliguria NNS cord-015306-us58wwmp 2853 7 to to IN cord-015306-us58wwmp 2853 8 seventh seventh JJ cord-015306-us58wwmp 2853 9 day day NN cord-015306-us58wwmp 2853 10 , , , cord-015306-us58wwmp 2853 11 when when WRB cord-015306-us58wwmp 2853 12 he -PRON- PRP cord-015306-us58wwmp 2853 13 could could MD cord-015306-us58wwmp 2853 14 n't not RB cord-015306-us58wwmp 2853 15 urinate urinate VB cord-015306-us58wwmp 2853 16 . . . cord-015306-us58wwmp 2854 1 Nativ Nativ NNP cord-015306-us58wwmp 2854 2 Rtg Rtg NNP cord-015306-us58wwmp 2854 3 of of IN cord-015306-us58wwmp 2854 4 abdomen abdomen NN cord-015306-us58wwmp 2854 5 resulted result VBD cord-015306-us58wwmp 2854 6 normal normal JJ cord-015306-us58wwmp 2854 7 . . . cord-015306-us58wwmp 2855 1 He -PRON- PRP cord-015306-us58wwmp 2855 2 was be VBD cord-015306-us58wwmp 2855 3 transferede transferede VBN cord-015306-us58wwmp 2855 4 to to IN cord-015306-us58wwmp 2855 5 Pediatric Pediatric NNP cord-015306-us58wwmp 2855 6 clinic clinic NN cord-015306-us58wwmp 2855 7 - - HYPH cord-015306-us58wwmp 2855 8 Nephrology Nephrology NNP cord-015306-us58wwmp 2855 9 department department NN cord-015306-us58wwmp 2855 10 as as IN cord-015306-us58wwmp 2855 11 an an DT cord-015306-us58wwmp 2855 12 Akute Akute NNP cord-015306-us58wwmp 2855 13 kidney kidney NN cord-015306-us58wwmp 2855 14 injory injory NN cord-015306-us58wwmp 2855 15 . . . cord-015306-us58wwmp 2856 1 He -PRON- PRP cord-015306-us58wwmp 2856 2 looked look VBD cord-015306-us58wwmp 2856 3 very very RB cord-015306-us58wwmp 2856 4 sick sick JJ cord-015306-us58wwmp 2856 5 , , , cord-015306-us58wwmp 2856 6 consious consious JJ cord-015306-us58wwmp 2856 7 , , , cord-015306-us58wwmp 2856 8 stratified stratified JJ cord-015306-us58wwmp 2856 9 tongue tongue NN cord-015306-us58wwmp 2856 10 , , , cord-015306-us58wwmp 2856 11 ECG ECG NNP cord-015306-us58wwmp 2856 12 : : : cord-015306-us58wwmp 2856 13 50b 50b NNS cord-015306-us58wwmp 2856 14 / / SYM cord-015306-us58wwmp 2856 15 min min NNP cord-015306-us58wwmp 2856 16 , , , cord-015306-us58wwmp 2856 17 BP BP NNP cord-015306-us58wwmp 2856 18 : : : cord-015306-us58wwmp 2857 1 115/60 115/60 CD cord-015306-us58wwmp 2857 2 mmHg mmHg NNS cord-015306-us58wwmp 2857 3 , , , cord-015306-us58wwmp 2857 4 breathing breathing NN cord-015306-us58wwmp 2857 5 sounds sound NNS cord-015306-us58wwmp 2857 6 were be VBD cord-015306-us58wwmp 2857 7 normal normal JJ cord-015306-us58wwmp 2857 8 , , , cord-015306-us58wwmp 2857 9 periferal periferal JJ cord-015306-us58wwmp 2857 10 edemas edema NNS cord-015306-us58wwmp 2857 11 and and CC cord-015306-us58wwmp 2857 12 cold cold JJ cord-015306-us58wwmp 2857 13 extremities extremity NNS cord-015306-us58wwmp 2857 14 . . . cord-015306-us58wwmp 2858 1 Lab lab NN cord-015306-us58wwmp 2858 2 resultrs resultrs NN cord-015306-us58wwmp 2858 3 : : : cord-015306-us58wwmp 2858 4 Cre Cre NNP cord-015306-us58wwmp 2858 5 : : : cord-015306-us58wwmp 2858 6 624 624 CD cord-015306-us58wwmp 2858 7 , , , cord-015306-us58wwmp 2858 8 BUN bun NN cord-015306-us58wwmp 2858 9 : : : cord-015306-us58wwmp 2858 10 16.6 16.6 CD cord-015306-us58wwmp 2858 11 , , , cord-015306-us58wwmp 2858 12 K k NN cord-015306-us58wwmp 2858 13 : : : cord-015306-us58wwmp 2858 14 5.1 5.1 CD cord-015306-us58wwmp 2859 1 , , , cord-015306-us58wwmp 2859 2 Na Na NNP cord-015306-us58wwmp 2859 3 : : : cord-015306-us58wwmp 2859 4 131 131 CD cord-015306-us58wwmp 2859 5 , , , cord-015306-us58wwmp 2859 6 eGFR egfr NN cord-015306-us58wwmp 2859 7 : : : cord-015306-us58wwmp 2859 8 8.8 8.8 CD cord-015306-us58wwmp 2859 9 ml ml NNS cord-015306-us58wwmp 2859 10 / / SYM cord-015306-us58wwmp 2859 11 min min NNP cord-015306-us58wwmp 2859 12 oer oer NNP cord-015306-us58wwmp 2859 13 1.73m2 1.73m2 CD cord-015306-us58wwmp 2859 14 . . . cord-015306-us58wwmp 2860 1 Ultrasound ultrasound NN cord-015306-us58wwmp 2860 2 resulterd resulterd NNP cord-015306-us58wwmp 2860 3 with with IN cord-015306-us58wwmp 2860 4 urinary urinary JJ cord-015306-us58wwmp 2860 5 stasis stasis NN cord-015306-us58wwmp 2860 6 : : : cord-015306-us58wwmp 2860 7 hydronephrosis hydronephrosis NN cord-015306-us58wwmp 2860 8 , , , cord-015306-us58wwmp 2860 9 huge huge JJ cord-015306-us58wwmp 2860 10 bladder bladder NN cord-015306-us58wwmp 2860 11 . . . cord-015306-us58wwmp 2861 1 First first RB cord-015306-us58wwmp 2861 2 was be VBD cord-015306-us58wwmp 2861 3 suspected suspect VBN cord-015306-us58wwmp 2861 4 for for IN cord-015306-us58wwmp 2861 5 acute acute JJ cord-015306-us58wwmp 2861 6 obstruction obstruction NN cord-015306-us58wwmp 2861 7 and and CC cord-015306-us58wwmp 2861 8 AKI AKI NNP cord-015306-us58wwmp 2861 9 couse couse NN cord-015306-us58wwmp 2861 10 of of IN cord-015306-us58wwmp 2861 11 a a DT cord-015306-us58wwmp 2861 12 medication medication NN cord-015306-us58wwmp 2861 13 . . . cord-015306-us58wwmp 2862 1 We -PRON- PRP cord-015306-us58wwmp 2862 2 changed change VBD cord-015306-us58wwmp 2862 3 a a DT cord-015306-us58wwmp 2862 4 bladder bladder NN cord-015306-us58wwmp 2862 5 cathether cathether NN cord-015306-us58wwmp 2862 6 which which WDT cord-015306-us58wwmp 2862 7 we -PRON- PRP cord-015306-us58wwmp 2862 8 find find VBP cord-015306-us58wwmp 2862 9 out out RP cord-015306-us58wwmp 2862 10 that that WDT cord-015306-us58wwmp 2862 11 was be VBD cord-015306-us58wwmp 2862 12 blocked block VBN cord-015306-us58wwmp 2862 13 and and CC cord-015306-us58wwmp 2862 14 took take VBD cord-015306-us58wwmp 2862 15 out out RP cord-015306-us58wwmp 2862 16 2700 2700 CD cord-015306-us58wwmp 2862 17 ml ml NNS cord-015306-us58wwmp 2862 18 urine/24h urine/24h NN cord-015306-us58wwmp 2862 19 . . . cord-015306-us58wwmp 2863 1 We -PRON- PRP cord-015306-us58wwmp 2863 2 Dialysed dialyse VBD cord-015306-us58wwmp 2863 3 him -PRON- PRP cord-015306-us58wwmp 2863 4 for for IN cord-015306-us58wwmp 2863 5 three three CD cord-015306-us58wwmp 2863 6 days day NNS cord-015306-us58wwmp 2863 7 and and CC cord-015306-us58wwmp 2863 8 cre cre NNP cord-015306-us58wwmp 2863 9 was be VBD cord-015306-us58wwmp 2863 10 stabilized stabilize VBN cord-015306-us58wwmp 2863 11 to to IN cord-015306-us58wwmp 2863 12 266 266 CD cord-015306-us58wwmp 2863 13 , , , cord-015306-us58wwmp 2863 14 when when WRB cord-015306-us58wwmp 2863 15 we -PRON- PRP cord-015306-us58wwmp 2863 16 stoped stop VBD cord-015306-us58wwmp 2863 17 dialyse dialyse NNP cord-015306-us58wwmp 2863 18 . . . cord-015306-us58wwmp 2864 1 BP BP NNP cord-015306-us58wwmp 2864 2 was be VBD cord-015306-us58wwmp 2864 3 stabile stabile JJ cord-015306-us58wwmp 2864 4 , , , cord-015306-us58wwmp 2864 5 his -PRON- PRP$ cord-015306-us58wwmp 2864 6 weight weight NN cord-015306-us58wwmp 2864 7 droped drop VBD cord-015306-us58wwmp 2864 8 from from IN cord-015306-us58wwmp 2864 9 32 32 CD cord-015306-us58wwmp 2864 10 kg kg NNS cord-015306-us58wwmp 2864 11 to to IN cord-015306-us58wwmp 2864 12 27.5 27.5 CD cord-015306-us58wwmp 2864 13 kg kg NNS cord-015306-us58wwmp 2864 14 . . . cord-015306-us58wwmp 2865 1 He -PRON- PRP cord-015306-us58wwmp 2865 2 had have VBD cord-015306-us58wwmp 2865 3 proteinuria proteinuria NN cord-015306-us58wwmp 2865 4 2 2 CD cord-015306-us58wwmp 2865 5 g/24 g/24 NN cord-015306-us58wwmp 2866 1 h. h. NNP cord-015306-us58wwmp 2866 2 Schintigraphy Schintigraphy NNP cord-015306-us58wwmp 2866 3 was be VBD cord-015306-us58wwmp 2866 4 done do VBN cord-015306-us58wwmp 2867 1 ( ( -LRB- cord-015306-us58wwmp 2867 2 biopsy biopsy NN cord-015306-us58wwmp 2867 3 we -PRON- PRP cord-015306-us58wwmp 2867 4 could could MD cord-015306-us58wwmp 2867 5 n't not RB cord-015306-us58wwmp 2867 6 do do VB cord-015306-us58wwmp 2867 7 ) ) -RRB- cord-015306-us58wwmp 2867 8 and and CC cord-015306-us58wwmp 2867 9 resulted result VBD cord-015306-us58wwmp 2867 10 : : : cord-015306-us58wwmp 2868 1 eGFR eGFR NNP cord-015306-us58wwmp 2868 2 was be VBD cord-015306-us58wwmp 2868 3 12 12 CD cord-015306-us58wwmp 2868 4 % % NN cord-015306-us58wwmp 2868 5 less less JJR cord-015306-us58wwmp 2868 6 than than IN cord-015306-us58wwmp 2868 7 adecuat adecuat NNP cord-015306-us58wwmp 2868 8 for for IN cord-015306-us58wwmp 2868 9 age age NN cord-015306-us58wwmp 2868 10 , , , cord-015306-us58wwmp 2868 11 suspected suspect VBN cord-015306-us58wwmp 2868 12 for for IN cord-015306-us58wwmp 2868 13 Nephritis nephritis NN cord-015306-us58wwmp 2868 14 tubulointestialis tubulointestialis JJ cord-015306-us58wwmp 2868 15 . . . cord-015306-us58wwmp 2869 1 He -PRON- PRP cord-015306-us58wwmp 2869 2 had have VBD cord-015306-us58wwmp 2869 3 some some DT cord-015306-us58wwmp 2869 4 toxoalergic toxoalergic NN cord-015306-us58wwmp 2869 5 exanthema exanthema NNP cord-015306-us58wwmp 2869 6 spread spread VBD cord-015306-us58wwmp 2869 7 to to IN cord-015306-us58wwmp 2869 8 the the DT cord-015306-us58wwmp 2869 9 body body NN cord-015306-us58wwmp 2869 10 . . . cord-015306-us58wwmp 2870 1 Repeted repete VBN cord-015306-us58wwmp 2870 2 US US NNP cord-015306-us58wwmp 2870 3 resulted result VBD cord-015306-us58wwmp 2870 4 with with IN cord-015306-us58wwmp 2870 5 ascaridosis ascaridosis NN cord-015306-us58wwmp 2870 6 in in IN cord-015306-us58wwmp 2870 7 the the DT cord-015306-us58wwmp 2870 8 gallbladder gallbladder NN cord-015306-us58wwmp 2870 9 , , , cord-015306-us58wwmp 2870 10 which which WDT cord-015306-us58wwmp 2870 11 was be VBD cord-015306-us58wwmp 2870 12 treated treat VBN cord-015306-us58wwmp 2870 13 with with IN cord-015306-us58wwmp 2870 14 Mebendazole Mebendazole NNP cord-015306-us58wwmp 2870 15 and and CC cord-015306-us58wwmp 2870 16 in in IN cord-015306-us58wwmp 2870 17 the the DT cord-015306-us58wwmp 2870 18 feces fece NNS cord-015306-us58wwmp 2870 19 were be VBD cord-015306-us58wwmp 2870 20 found find VBN cord-015306-us58wwmp 2870 21 the the DT cord-015306-us58wwmp 2870 22 parasites parasite NNS cord-015306-us58wwmp 2870 23 . . . cord-015306-us58wwmp 2871 1 Imune Imune NNP cord-015306-us58wwmp 2871 2 Ab Ab NNP cord-015306-us58wwmp 2871 3 were be VBD cord-015306-us58wwmp 2871 4 negativ negativ NNP cord-015306-us58wwmp 2871 5 , , , cord-015306-us58wwmp 2871 6 IgE IgE NNP cord-015306-us58wwmp 2871 7 : : : cord-015306-us58wwmp 2871 8 positive positive JJ cord-015306-us58wwmp 2871 9 , , , cord-015306-us58wwmp 2871 10 periferal periferal JJ cord-015306-us58wwmp 2871 11 blood blood NN cord-015306-us58wwmp 2871 12 smear smear NN cord-015306-us58wwmp 2872 1 had have VBD cord-015306-us58wwmp 2872 2 eosinophils eosinophil NNS cord-015306-us58wwmp 2872 3 , , , cord-015306-us58wwmp 2872 4 wastage wastage NN cord-015306-us58wwmp 2872 5 of of IN cord-015306-us58wwmp 2872 6 Na Na NNP cord-015306-us58wwmp 2872 7 and and CC cord-015306-us58wwmp 2872 8 Mg Mg NNP cord-015306-us58wwmp 2872 9 with with IN cord-015306-us58wwmp 2872 10 urine urine NN cord-015306-us58wwmp 2872 11 . . . cord-015306-us58wwmp 2873 1 Cre Cre NNP cord-015306-us58wwmp 2873 2 after after IN cord-015306-us58wwmp 2873 3 four four CD cord-015306-us58wwmp 2873 4 weeks week NNS cord-015306-us58wwmp 2873 5 was be VBD cord-015306-us58wwmp 2873 6 58 58 CD cord-015306-us58wwmp 2873 7 , , , cord-015306-us58wwmp 2873 8 BUN:5 bun:5 UH cord-015306-us58wwmp 2873 9 , , , cord-015306-us58wwmp 2873 10 negative negative JJ cord-015306-us58wwmp 2873 11 proteinuria proteinuria NN cord-015306-us58wwmp 2873 12 . . . cord-015306-us58wwmp 2874 1 No no DT cord-015306-us58wwmp 2874 2 changes change NNS cord-015306-us58wwmp 2874 3 of of IN cord-015306-us58wwmp 2874 4 uveitis uveitis NN cord-015306-us58wwmp 2874 5 in in IN cord-015306-us58wwmp 2874 6 the the DT cord-015306-us58wwmp 2874 7 eyes eye NNS cord-015306-us58wwmp 2874 8 . . . cord-015306-us58wwmp 2875 1 Importance importance NN cord-015306-us58wwmp 2875 2 of of IN cord-015306-us58wwmp 2875 3 this this DT cord-015306-us58wwmp 2875 4 case case NN cord-015306-us58wwmp 2875 5 is be VBZ cord-015306-us58wwmp 2875 6 cause cause IN cord-015306-us58wwmp 2875 7 this this DT cord-015306-us58wwmp 2875 8 is be VBZ cord-015306-us58wwmp 2875 9 the the DT cord-015306-us58wwmp 2875 10 first first JJ cord-015306-us58wwmp 2875 11 case case NN cord-015306-us58wwmp 2875 12 in in IN cord-015306-us58wwmp 2875 13 Kosova Kosova NNP cord-015306-us58wwmp 2875 14 that that WDT cord-015306-us58wwmp 2875 15 was be VBD cord-015306-us58wwmp 2875 16 dialysed dialyse VBN cord-015306-us58wwmp 2875 17 and and CC cord-015306-us58wwmp 2875 18 has have VBZ cord-015306-us58wwmp 2875 19 recovered recover VBN cord-015306-us58wwmp 2875 20 and and CC cord-015306-us58wwmp 2875 21 now now RB cord-015306-us58wwmp 2875 22 is be VBZ cord-015306-us58wwmp 2875 23 free free JJ cord-015306-us58wwmp 2875 24 of of IN cord-015306-us58wwmp 2875 25 dialyse dialyse NN cord-015306-us58wwmp 2875 26 ( ( -LRB- cord-015306-us58wwmp 2875 27 all all DT cord-015306-us58wwmp 2875 28 other other JJ cord-015306-us58wwmp 2875 29 cases case NNS cord-015306-us58wwmp 2875 30 have have VBP cord-015306-us58wwmp 2875 31 traveled travel VBN cord-015306-us58wwmp 2875 32 abroad abroad RB cord-015306-us58wwmp 2875 33 until until IN cord-015306-us58wwmp 2875 34 then then RB cord-015306-us58wwmp 2875 35 ) ) -RRB- cord-015306-us58wwmp 2875 36 . . . cord-015306-us58wwmp 2876 1 Conclusion conclusion NN cord-015306-us58wwmp 2876 2 : : : cord-015306-us58wwmp 2876 3 We -PRON- PRP cord-015306-us58wwmp 2876 4 have have VBP cord-015306-us58wwmp 2876 5 to to TO cord-015306-us58wwmp 2876 6 think think VB cord-015306-us58wwmp 2876 7 for for IN cord-015306-us58wwmp 2876 8 parasites parasite NNS cord-015306-us58wwmp 2876 9 as as IN cord-015306-us58wwmp 2876 10 a a DT cord-015306-us58wwmp 2876 11 cause cause NN cord-015306-us58wwmp 2876 12 of of IN cord-015306-us58wwmp 2876 13 a a DT cord-015306-us58wwmp 2876 14 Tubulointesticial Tubulointesticial NNP cord-015306-us58wwmp 2876 15 Nephritis Nephritis NNP cord-015306-us58wwmp 2876 16 but but CC cord-015306-us58wwmp 2876 17 also also RB cord-015306-us58wwmp 2876 18 of of IN cord-015306-us58wwmp 2876 19 a a DT cord-015306-us58wwmp 2876 20 abdominal abdominal JJ cord-015306-us58wwmp 2876 21 pain pain NN cord-015306-us58wwmp 2876 22 or or CC cord-015306-us58wwmp 2876 23 fatigue fatigue NN cord-015306-us58wwmp 2876 24 . . . cord-015306-us58wwmp 2877 1 Surgery surgery NN cord-015306-us58wwmp 2877 2 team team NN cord-015306-us58wwmp 2877 3 should should MD cord-015306-us58wwmp 2877 4 have have VB cord-015306-us58wwmp 2877 5 a a DT cord-015306-us58wwmp 2877 6 close close JJ cord-015306-us58wwmp 2877 7 cooperation cooperation NN cord-015306-us58wwmp 2877 8 with with IN cord-015306-us58wwmp 2877 9 pediatricians pediatrician NNS cord-015306-us58wwmp 2877 10 , , , cord-015306-us58wwmp 2877 11 in in IN cord-015306-us58wwmp 2877 12 order order NN cord-015306-us58wwmp 2877 13 to to IN cord-015306-us58wwmp 2877 14 identifye identifye NNP cord-015306-us58wwmp 2877 15 in in IN cord-015306-us58wwmp 2877 16 time time NN cord-015306-us58wwmp 2877 17 complications complication NNS cord-015306-us58wwmp 2877 18 of of IN cord-015306-us58wwmp 2877 19 the the DT cord-015306-us58wwmp 2877 20 surgery surgery NN cord-015306-us58wwmp 2877 21 . . . cord-015306-us58wwmp 2878 1 Urine urine NN cord-015306-us58wwmp 2878 2 output output NN cord-015306-us58wwmp 2878 3 in in IN cord-015306-us58wwmp 2878 4 first first JJ cord-015306-us58wwmp 2878 5 48 48 CD cord-015306-us58wwmp 2878 6 hours hour NNS cord-015306-us58wwmp 2878 7 after after IN cord-015306-us58wwmp 2878 8 birth birth NN cord-015306-us58wwmp 2878 9 in in IN cord-015306-us58wwmp 2878 10 relation relation NN cord-015306-us58wwmp 2878 11 to to IN cord-015306-us58wwmp 2878 12 AKIN akin NN cord-015306-us58wwmp 2878 13 criteria criterion NNS cord-015306-us58wwmp 2879 1 Saroj Saroj NNP cord-015306-us58wwmp 2879 2 Kumar Kumar NNP cord-015306-us58wwmp 2879 3 Patnaik Patnaik NNP cord-015306-us58wwmp 2879 4 , , , cord-015306-us58wwmp 2879 5 Gaurav Gaurav NNP cord-015306-us58wwmp 2879 6 Aggarwal Aggarwal NNP cord-015306-us58wwmp 2879 7 , , , cord-015306-us58wwmp 2879 8 Uday Uday NNP cord-015306-us58wwmp 2879 9 Kumar Kumar NNP cord-015306-us58wwmp 2879 10 , , , cord-015306-us58wwmp 2879 11 Vempati Vempati NNP cord-015306-us58wwmp 2879 12 Venkateshwar Venkateshwar NNP cord-015306-us58wwmp 2879 13 , , , cord-015306-us58wwmp 2879 14 Shamsher Shamsher NNP cord-015306-us58wwmp 2879 15 Singh Singh NNP cord-015306-us58wwmp 2879 16 Dalal Dalal NNP cord-015306-us58wwmp 2879 17 Pediatrics Pediatrics NNP cord-015306-us58wwmp 2879 18 , , , cord-015306-us58wwmp 2879 19 Command Command NNP cord-015306-us58wwmp 2879 20 Hospital Hospital NNP cord-015306-us58wwmp 2879 21 Air Air NNP cord-015306-us58wwmp 2879 22 Force Force NNP cord-015306-us58wwmp 2879 23 , , , cord-015306-us58wwmp 2879 24 Bangalore Bangalore NNP cord-015306-us58wwmp 2879 25 , , , cord-015306-us58wwmp 2880 1 India India NNP cord-015306-us58wwmp 2880 2 Objective Objective NNP cord-015306-us58wwmp 2880 3 : : : cord-015306-us58wwmp 2881 1 Applicability applicability NN cord-015306-us58wwmp 2881 2 of of IN cord-015306-us58wwmp 2881 3 AKIN akin NN cord-015306-us58wwmp 2881 4 urinary urinary JJ cord-015306-us58wwmp 2881 5 output output NN cord-015306-us58wwmp 2881 6 ( ( -LRB- cord-015306-us58wwmp 2881 7 UO UO NNP cord-015306-us58wwmp 2881 8 ) ) -RRB- cord-015306-us58wwmp 2881 9 criteria criterion NNS cord-015306-us58wwmp 2881 10 in in IN cord-015306-us58wwmp 2881 11 neonates neonate NNS cord-015306-us58wwmp 2881 12 during during IN cord-015306-us58wwmp 2881 13 first first JJ cord-015306-us58wwmp 2881 14 48 48 CD cord-015306-us58wwmp 2881 15 hours hour NNS cord-015306-us58wwmp 2881 16 of of IN cord-015306-us58wwmp 2881 17 life life NN cord-015306-us58wwmp 2881 18 remains remain VBZ cord-015306-us58wwmp 2881 19 contentious contentious JJ cord-015306-us58wwmp 2881 20 since since IN cord-015306-us58wwmp 2881 21 nonpassage nonpassage NN cord-015306-us58wwmp 2881 22 of of IN cord-015306-us58wwmp 2881 23 urine urine NN cord-015306-us58wwmp 2881 24 during during IN cord-015306-us58wwmp 2881 25 this this DT cord-015306-us58wwmp 2881 26 time time NN cord-015306-us58wwmp 2881 27 has have VBZ cord-015306-us58wwmp 2881 28 traditionally traditionally RB cord-015306-us58wwmp 2881 29 been be VBN cord-015306-us58wwmp 2881 30 considered consider VBN cord-015306-us58wwmp 2881 31 ' ' `` cord-015306-us58wwmp 2881 32 normal normal JJ cord-015306-us58wwmp 2881 33 ' ' '' cord-015306-us58wwmp 2881 34 . . . cord-015306-us58wwmp 2882 1 We -PRON- PRP cord-015306-us58wwmp 2882 2 hypothesize hypothesize VBP cord-015306-us58wwmp 2882 3 that that IN cord-015306-us58wwmp 2882 4 ' ' `` cord-015306-us58wwmp 2882 5 physiological physiological JJ cord-015306-us58wwmp 2882 6 ' ' '' cord-015306-us58wwmp 2882 7 oliguria oliguria NN cord-015306-us58wwmp 2882 8 in in IN cord-015306-us58wwmp 2882 9 first first JJ cord-015306-us58wwmp 2882 10 48 48 CD cord-015306-us58wwmp 2882 11 hours hour NNS cord-015306-us58wwmp 2882 12 of of IN cord-015306-us58wwmp 2882 13 life life NN cord-015306-us58wwmp 2882 14 is be VBZ cord-015306-us58wwmp 2882 15 mostly mostly RB cord-015306-us58wwmp 2882 16 prerenal prerenal JJ cord-015306-us58wwmp 2882 17 in in IN cord-015306-us58wwmp 2882 18 origin origin NN cord-015306-us58wwmp 2882 19 related relate VBN cord-015306-us58wwmp 2882 20 to to IN cord-015306-us58wwmp 2882 21 poor poor JJ cord-015306-us58wwmp 2882 22 fluid fluid NN cord-015306-us58wwmp 2882 23 intake intake NN cord-015306-us58wwmp 2882 24 during during IN cord-015306-us58wwmp 2882 25 transition transition NN cord-015306-us58wwmp 2882 26 and and CC cord-015306-us58wwmp 2882 27 UO UO NNP cord-015306-us58wwmp 2882 28 criteria criterion NNS cord-015306-us58wwmp 2882 29 should should MD cord-015306-us58wwmp 2882 30 be be VB cord-015306-us58wwmp 2882 31 applicable applicable JJ cord-015306-us58wwmp 2882 32 in in IN cord-015306-us58wwmp 2882 33 the the DT cord-015306-us58wwmp 2882 34 1st 1st JJ cord-015306-us58wwmp 2882 35 48 48 CD cord-015306-us58wwmp 2882 36 hours hour NNS cord-015306-us58wwmp 2882 37 of of IN cord-015306-us58wwmp 2882 38 life life NN cord-015306-us58wwmp 2882 39 too too RB cord-015306-us58wwmp 2882 40 . . . cord-015306-us58wwmp 2883 1 We -PRON- PRP cord-015306-us58wwmp 2883 2 aimed aim VBD cord-015306-us58wwmp 2883 3 a a LS cord-015306-us58wwmp 2883 4 ) ) -RRB- cord-015306-us58wwmp 2883 5 to to TO cord-015306-us58wwmp 2883 6 investigate investigate VB cord-015306-us58wwmp 2883 7 pattern pattern NN cord-015306-us58wwmp 2883 8 of of IN cord-015306-us58wwmp 2883 9 UO uo NN cord-015306-us58wwmp 2883 10 in in IN cord-015306-us58wwmp 2883 11 babies baby NNS cord-015306-us58wwmp 2883 12 admitted admit VBN cord-015306-us58wwmp 2883 13 to to IN cord-015306-us58wwmp 2883 14 NICU NICU NNP cord-015306-us58wwmp 2883 15 with with IN cord-015306-us58wwmp 2883 16 underlying underlying JJ cord-015306-us58wwmp 2883 17 morbidity morbidity NN cord-015306-us58wwmp 2883 18 but but CC cord-015306-us58wwmp 2883 19 regulated regulated JJ cord-015306-us58wwmp 2883 20 fluid fluid JJ cord-015306-us58wwmp 2883 21 intake intake NN cord-015306-us58wwmp 2883 22 versus versus IN cord-015306-us58wwmp 2883 23 roomed room VBN cord-015306-us58wwmp 2883 24 - - HYPH cord-015306-us58wwmp 2883 25 in in IN cord-015306-us58wwmp 2883 26 babies baby NNS cord-015306-us58wwmp 2883 27 in in IN cord-015306-us58wwmp 2883 28 postnatal postnatal JJ cord-015306-us58wwmp 2883 29 ward ward NN cord-015306-us58wwmp 2883 30 on on IN cord-015306-us58wwmp 2883 31 breastfeeds breastfeed NNS cord-015306-us58wwmp 2883 32 in in IN cord-015306-us58wwmp 2883 33 first first JJ cord-015306-us58wwmp 2883 34 48 48 CD cord-015306-us58wwmp 2883 35 hours hour NNS cord-015306-us58wwmp 2883 36 of of IN cord-015306-us58wwmp 2883 37 life life NN cord-015306-us58wwmp 2883 38 ; ; : cord-015306-us58wwmp 2883 39 b b LS cord-015306-us58wwmp 2883 40 ) ) -RRB- cord-015306-us58wwmp 2883 41 to to TO cord-015306-us58wwmp 2883 42 relate relate VB cord-015306-us58wwmp 2883 43 UO UO NNP cord-015306-us58wwmp 2883 44 till till IN cord-015306-us58wwmp 2883 45 48 48 CD cord-015306-us58wwmp 2883 46 hrs hrs NN cord-015306-us58wwmp 2883 47 of of IN cord-015306-us58wwmp 2883 48 life life NN cord-015306-us58wwmp 2883 49 with with IN cord-015306-us58wwmp 2883 50 development development NN cord-015306-us58wwmp 2883 51 of of IN cord-015306-us58wwmp 2883 52 AKI AKI NNP cord-015306-us58wwmp 2883 53 Methods method NNS cord-015306-us58wwmp 2883 54 : : : cord-015306-us58wwmp 2884 1 Prospectively prospectively RB cord-015306-us58wwmp 2884 2 timing timing NN cord-015306-us58wwmp 2884 3 of of IN cord-015306-us58wwmp 2884 4 first first JJ cord-015306-us58wwmp 2884 5 void void JJ cord-015306-us58wwmp 2884 6 and and CC cord-015306-us58wwmp 2884 7 6 6 CD cord-015306-us58wwmp 2884 8 hourly hourly JJ cord-015306-us58wwmp 2884 9 UO uo NN cord-015306-us58wwmp 2884 10 from from IN cord-015306-us58wwmp 2884 11 birth birth NN cord-015306-us58wwmp 2884 12 till till IN cord-015306-us58wwmp 2884 13 48 48 CD cord-015306-us58wwmp 2884 14 hours hour NNS cord-015306-us58wwmp 2884 15 age age NN cord-015306-us58wwmp 2884 16 was be VBD cord-015306-us58wwmp 2884 17 compared compare VBN cord-015306-us58wwmp 2884 18 between between IN cord-015306-us58wwmp 2884 19 consecutive consecutive JJ cord-015306-us58wwmp 2884 20 postnatal postnatal JJ cord-015306-us58wwmp 2884 21 ward ward NN cord-015306-us58wwmp 2884 22 and and CC cord-015306-us58wwmp 2884 23 NICU NICU NNP cord-015306-us58wwmp 2884 24 admissions admission NNS cord-015306-us58wwmp 2884 25 . . . cord-015306-us58wwmp 2885 1 Neonates neonate NNS cord-015306-us58wwmp 2885 2 with with IN cord-015306-us58wwmp 2885 3 structural structural JJ cord-015306-us58wwmp 2885 4 malformations malformation NNS cord-015306-us58wwmp 2885 5 and and CC cord-015306-us58wwmp 2885 6 requiring require VBG cord-015306-us58wwmp 2885 7 ventilatory ventilatory NN cord-015306-us58wwmp 2885 8 / / SYM cord-015306-us58wwmp 2885 9 vasopressor vasopressor NN cord-015306-us58wwmp 2885 10 support support NN cord-015306-us58wwmp 2885 11 were be VBD cord-015306-us58wwmp 2885 12 excluded exclude VBN cord-015306-us58wwmp 2885 13 . . . cord-015306-us58wwmp 2886 1 Outcomes outcome NNS cord-015306-us58wwmp 2886 2 - - : cord-015306-us58wwmp 2886 3 Primary primary JJ cord-015306-us58wwmp 2886 4 : : : cord-015306-us58wwmp 2886 5 time time NN cord-015306-us58wwmp 2886 6 of of IN cord-015306-us58wwmp 2886 7 first first JJ cord-015306-us58wwmp 2886 8 void void NN cord-015306-us58wwmp 2886 9 after after IN cord-015306-us58wwmp 2886 10 birth birth NN cord-015306-us58wwmp 2886 11 Secondary Secondary NNP cord-015306-us58wwmp 2886 12 : : : cord-015306-us58wwmp 2886 13 UO UO NNP cord-015306-us58wwmp 2886 14 in in IN cord-015306-us58wwmp 2886 15 1st 1st JJ cord-015306-us58wwmp 2886 16 48 48 CD cord-015306-us58wwmp 2886 17 hrs hrs NN cord-015306-us58wwmp 2886 18 in in IN cord-015306-us58wwmp 2886 19 relation relation NN cord-015306-us58wwmp 2886 20 to to IN cord-015306-us58wwmp 2886 21 subsequent subsequent JJ cord-015306-us58wwmp 2886 22 AKI AKI NNP cord-015306-us58wwmp 2886 23 Results result NNS cord-015306-us58wwmp 2886 24 : : : cord-015306-us58wwmp 2887 1 Amongst amongst IN cord-015306-us58wwmp 2887 2 eligible eligible JJ cord-015306-us58wwmp 2887 3 87 87 CD cord-015306-us58wwmp 2887 4 postnatal postnatal NN cord-015306-us58wwmp 2887 5 breastfed breastfe VBN cord-015306-us58wwmp 2887 6 babies baby NNS cord-015306-us58wwmp 2887 7 ( ( -LRB- cord-015306-us58wwmp 2887 8 mean mean VB cord-015306-us58wwmp 2887 9 bwt bwt NNP cord-015306-us58wwmp 2887 10 2.86 2.86 CD cord-015306-us58wwmp 2887 11 Kg Kg NNP cord-015306-us58wwmp 2887 12 ; ; : cord-015306-us58wwmp 2887 13 SGA SGA NNP cord-015306-us58wwmp 2887 14 18 18 CD cord-015306-us58wwmp 2887 15 ; ; : cord-015306-us58wwmp 2887 16 27 27 CD cord-015306-us58wwmp 2887 17 LSCS LSCS NNP cord-015306-us58wwmp 2887 18 born bear VBN cord-015306-us58wwmp 2887 19 ) ) -RRB- cord-015306-us58wwmp 2887 20 and and CC cord-015306-us58wwmp 2887 21 110 110 CD cord-015306-us58wwmp 2887 22 NICU NICU NNP cord-015306-us58wwmp 2887 23 admissions admission NNS cord-015306-us58wwmp 2887 24 ( ( -LRB- cord-015306-us58wwmp 2887 25 median median JJ cord-015306-us58wwmp 2887 26 birthweight birthweight JJ cord-015306-us58wwmp 2887 27 2.01 2.01 CD cord-015306-us58wwmp 2887 28 kg kg NNS cord-015306-us58wwmp 2887 29 , , , cord-015306-us58wwmp 2887 30 mean mean VB cord-015306-us58wwmp 2887 31 GA GA NNP cord-015306-us58wwmp 2887 32 34 34 CD cord-015306-us58wwmp 2887 33 wks wks NN cord-015306-us58wwmp 2887 34 ( ( -LRB- cord-015306-us58wwmp 2887 35 26 26 CD cord-015306-us58wwmp 2887 36 - - SYM cord-015306-us58wwmp 2887 37 43 43 CD cord-015306-us58wwmp 2887 38 wks wks NN cord-015306-us58wwmp 2887 39 ) ) -RRB- cord-015306-us58wwmp 2887 40 ; ; : cord-015306-us58wwmp 2887 41 67 67 CD cord-015306-us58wwmp 2887 42 prematures premature NNS cord-015306-us58wwmp 2887 43 ( ( -LRB- cord-015306-us58wwmp 2887 44 10 10 CD cord-015306-us58wwmp 2887 45 < < SYM cord-015306-us58wwmp 2887 46 30 30 CD cord-015306-us58wwmp 2887 47 wks wks NN cord-015306-us58wwmp 2887 48 ) ) -RRB- cord-015306-us58wwmp 2887 49 ; ; : cord-015306-us58wwmp 2888 1 82 82 CD cord-015306-us58wwmp 2888 2 SGA SGA NNP cord-015306-us58wwmp 2888 3 ( ( -LRB- cord-015306-us58wwmp 2888 4 6 6 CD cord-015306-us58wwmp 2888 5 ELBW ELBW NNP cord-015306-us58wwmp 2888 6 ) ) -RRB- cord-015306-us58wwmp 2888 7 recruited recruit VBN cord-015306-us58wwmp 2888 8 after after IN cord-015306-us58wwmp 2888 9 informed informed JJ cord-015306-us58wwmp 2888 10 consent consent NN cord-015306-us58wwmp 2888 11 , , , cord-015306-us58wwmp 2888 12 first first JJ cord-015306-us58wwmp 2888 13 voiding voiding NN cord-015306-us58wwmp 2888 14 was be VBD cord-015306-us58wwmp 2888 15 significantly significantly RB cord-015306-us58wwmp 2888 16 earlier early RBR cord-015306-us58wwmp 2888 17 for for IN cord-015306-us58wwmp 2888 18 NICU NICU NNP cord-015306-us58wwmp 2888 19 babies baby NNS cord-015306-us58wwmp 2888 20 ( ( -LRB- cord-015306-us58wwmp 2888 21 Mean(95%CI Mean(95%CI NNP cord-015306-us58wwmp 2888 22 ) ) -RRB- cord-015306-us58wwmp 2889 1 ( ( -LRB- cord-015306-us58wwmp 2889 2 hrs hrs NN cord-015306-us58wwmp 2889 3 ) ) -RRB- cord-015306-us58wwmp 2890 1 Postnatal postnatal NN cord-015306-us58wwmp 2890 2 4.12 4.12 CD cord-015306-us58wwmp 2890 3 ( ( -LRB- cord-015306-us58wwmp 2890 4 3.29 3.29 CD cord-015306-us58wwmp 2890 5 , , , cord-015306-us58wwmp 2890 6 4 4 CD cord-015306-us58wwmp 2890 7 .93 .93 CD cord-015306-us58wwmp 2890 8 ) ) -RRB- cord-015306-us58wwmp 2890 9 vs vs IN cord-015306-us58wwmp 2890 10 NICU NICU NNP cord-015306-us58wwmp 2890 11 2.31 2.31 CD cord-015306-us58wwmp 2890 12 ( ( -LRB- cord-015306-us58wwmp 2890 13 1.50,3.12 1.50,3.12 CD cord-015306-us58wwmp 2890 14 ) ) -RRB- cord-015306-us58wwmp 2890 15 hrs hrs NN cord-015306-us58wwmp 2890 16 ) ) -RRB- cord-015306-us58wwmp 2890 17 . . . cord-015306-us58wwmp 2891 1 Nonvaginal nonvaginal JJ cord-015306-us58wwmp 2892 1 delivery(LSCS delivery(LSCS NFP cord-015306-us58wwmp 2892 2 3.00 3.00 CD cord-015306-us58wwmp 2892 3 ( ( -LRB- cord-015306-us58wwmp 2892 4 1.89,4.11 1.89,4.11 CD cord-015306-us58wwmp 2892 5 ) ) -RRB- cord-015306-us58wwmp 2892 6 vs vs IN cord-015306-us58wwmp 2892 7 vaginal vaginal JJ cord-015306-us58wwmp 2892 8 4.68 4.68 CD cord-015306-us58wwmp 2892 9 ( ( -LRB- cord-015306-us58wwmp 2892 10 3.60,5.75 3.60,5.75 CD cord-015306-us58wwmp 2892 11 ) ) -RRB- cord-015306-us58wwmp 2892 12 and and CC cord-015306-us58wwmp 2892 13 normal normal JJ cord-015306-us58wwmp 2892 14 birthweight birthweight NNS cord-015306-us58wwmp 2892 15 ( ( -LRB- cord-015306-us58wwmp 2892 16 AGA AGA NNP cord-015306-us58wwmp 2892 17 4.08(3.10 4.08(3.10 CD cord-015306-us58wwmp 2892 18 , , , cord-015306-us58wwmp 2892 19 5.06 5.06 CD cord-015306-us58wwmp 2892 20 ) ) -RRB- cord-015306-us58wwmp 2892 21 vs vs IN cord-015306-us58wwmp 2892 22 SGA SGA NNP cord-015306-us58wwmp 2892 23 4.22(2.81 4.22(2.81 CD cord-015306-us58wwmp 2892 24 , , , cord-015306-us58wwmp 2892 25 5.63 5.63 CD cord-015306-us58wwmp 2892 26 ) ) -RRB- cord-015306-us58wwmp 2892 27 ) ) -RRB- cord-015306-us58wwmp 2892 28 had have VBD cord-015306-us58wwmp 2892 29 a a DT cord-015306-us58wwmp 2892 30 trend trend NN cord-015306-us58wwmp 2892 31 for for IN cord-015306-us58wwmp 2892 32 earlier early JJR cord-015306-us58wwmp 2892 33 voiding voiding NN cord-015306-us58wwmp 2892 34 . . . cord-015306-us58wwmp 2893 1 80 80 CD cord-015306-us58wwmp 2893 2 % % NN cord-015306-us58wwmp 2893 3 babies baby NNS cord-015306-us58wwmp 2893 4 voided void VBN cord-015306-us58wwmp 2893 5 within within IN cord-015306-us58wwmp 2893 6 6 6 CD cord-015306-us58wwmp 2893 7 hrs hrs NN cord-015306-us58wwmp 2893 8 of of IN cord-015306-us58wwmp 2893 9 birth birth NN cord-015306-us58wwmp 2893 10 -more -more . cord-015306-us58wwmp 2894 1 in in IN cord-015306-us58wwmp 2894 2 NICU NICU NNP cord-015306-us58wwmp 2894 3 babies baby NNS cord-015306-us58wwmp 2894 4 ( ( -LRB- cord-015306-us58wwmp 2894 5 90.4 90.4 CD cord-015306-us58wwmp 2894 6 % % NN cord-015306-us58wwmp 2894 7 NICU NICU NNP cord-015306-us58wwmp 2894 8 vs vs IN cord-015306-us58wwmp 2894 9 76.7 76.7 CD cord-015306-us58wwmp 2894 10 % % NN cord-015306-us58wwmp 2894 11 postnatal postnatal JJ cord-015306-us58wwmp 2894 12 ( ( -LRB- cord-015306-us58wwmp 2894 13 p<0.004 p<0.004 CD cord-015306-us58wwmp 2894 14 ) ) -RRB- cord-015306-us58wwmp 2895 1 ( ( -LRB- cord-015306-us58wwmp 2895 2 Fig Fig NNP cord-015306-us58wwmp 2895 3 ) ) -RRB- cord-015306-us58wwmp 2895 4 .Asphyxia .Asphyxia NFP cord-015306-us58wwmp 2895 5 with with IN cord-015306-us58wwmp 2895 6 MAS MAS NNP cord-015306-us58wwmp 2895 7 in in IN cord-015306-us58wwmp 2895 8 NICU NICU NNP cord-015306-us58wwmp 2895 9 and and CC cord-015306-us58wwmp 2895 10 IUGR IUGR NNP cord-015306-us58wwmp 2895 11 and and CC cord-015306-us58wwmp 2895 12 poor poor JJ cord-015306-us58wwmp 2895 13 feeding feeding NN cord-015306-us58wwmp 2895 14 in in IN cord-015306-us58wwmp 2895 15 postnatal postnatal JJ cord-015306-us58wwmp 2895 16 ward ward NN cord-015306-us58wwmp 2895 17 had have VBD cord-015306-us58wwmp 2895 18 delayed delay VBN cord-015306-us58wwmp 2895 19 first first JJ cord-015306-us58wwmp 2895 20 void void NN cord-015306-us58wwmp 2895 21 beyond beyond IN cord-015306-us58wwmp 2895 22 12 12 CD cord-015306-us58wwmp 2895 23 hours hour NNS cord-015306-us58wwmp 2895 24 . . . cord-015306-us58wwmp 2896 1 6 6 CD cord-015306-us58wwmp 2896 2 postnatal postnatal NN cord-015306-us58wwmp 2896 3 and and CC cord-015306-us58wwmp 2896 4 7 7 CD cord-015306-us58wwmp 2896 5 NICU NICU NNP cord-015306-us58wwmp 2896 6 neonates neonate NNS cord-015306-us58wwmp 2896 7 anuric anuric RB cord-015306-us58wwmp 2896 8 in in IN cord-015306-us58wwmp 2896 9 1st 1st JJ cord-015306-us58wwmp 2896 10 6hrs 6hrs CD cord-015306-us58wwmp 2897 1 met meet VBD cord-015306-us58wwmp 2897 2 stage stage NN cord-015306-us58wwmp 2898 1 I -PRON- PRP cord-015306-us58wwmp 2898 2 AKIN akin RB cord-015306-us58wwmp 2898 3 creatinine creatinine NN cord-015306-us58wwmp 2898 4 criteria criterion NNS cord-015306-us58wwmp 2898 5 . . . cord-015306-us58wwmp 2899 1 2 2 LS cord-015306-us58wwmp 2899 2 asphyxiated asphyxiate VBN cord-015306-us58wwmp 2899 3 babies baby NNS cord-015306-us58wwmp 2899 4 anuric anuric RB cord-015306-us58wwmp 2899 5 beyond beyond IN cord-015306-us58wwmp 2899 6 12 12 CD cord-015306-us58wwmp 2899 7 hours hour NNS cord-015306-us58wwmp 2899 8 in in IN cord-015306-us58wwmp 2899 9 NICU NICU NNP cord-015306-us58wwmp 2900 1 developed developed JJ cord-015306-us58wwmp 2900 2 Stage Stage NNP cord-015306-us58wwmp 2900 3 III III NNP cord-015306-us58wwmp 2900 4 AKI AKI NNP cord-015306-us58wwmp 2900 5 . . . cord-015306-us58wwmp 2901 1 Conclusion conclusion NN cord-015306-us58wwmp 2901 2 : : : cord-015306-us58wwmp 2901 3 ' ' `` cord-015306-us58wwmp 2901 4 Physiological physiological JJ cord-015306-us58wwmp 2901 5 ' ' POS cord-015306-us58wwmp 2901 6 anuria anuria NN cord-015306-us58wwmp 2901 7 in in IN cord-015306-us58wwmp 2901 8 1st 1st NN cord-015306-us58wwmp 2902 1 48 48 CD cord-015306-us58wwmp 2902 2 hrs hrs NN cord-015306-us58wwmp 2902 3 of of IN cord-015306-us58wwmp 2902 4 life life NN cord-015306-us58wwmp 2902 5 is be VBZ cord-015306-us58wwmp 2902 6 misnomer misnomer NN cord-015306-us58wwmp 2902 7 and and CC cord-015306-us58wwmp 2902 8 is be VBZ cord-015306-us58wwmp 2902 9 related relate VBN cord-015306-us58wwmp 2902 10 to to IN cord-015306-us58wwmp 2902 11 fluid fluid JJ cord-015306-us58wwmp 2902 12 intake intake NN cord-015306-us58wwmp 2902 13 . . . cord-015306-us58wwmp 2903 1 Most Most JJS cord-015306-us58wwmp 2903 2 babies baby NNS cord-015306-us58wwmp 2903 3 are be VBP cord-015306-us58wwmp 2903 4 nonoliguric nonoliguric JJ cord-015306-us58wwmp 2903 5 by by IN cord-015306-us58wwmp 2903 6 6 6 CD cord-015306-us58wwmp 2903 7 h h NN cord-015306-us58wwmp 2903 8 ; ; : cord-015306-us58wwmp 2903 9 anuria anuria NNP cord-015306-us58wwmp 2903 10 > > XX cord-015306-us58wwmp 2903 11 12 12 CD cord-015306-us58wwmp 2903 12 h h NNP cord-015306-us58wwmp 2903 13 needs need VBZ cord-015306-us58wwmp 2903 14 investigation investigation NN cord-015306-us58wwmp 2903 15 . . . cord-015306-us58wwmp 2904 1 AKIN AKIN NNP cord-015306-us58wwmp 2904 2 urinary urinary JJ cord-015306-us58wwmp 2904 3 criteria criterion NNS cord-015306-us58wwmp 2904 4 should should MD cord-015306-us58wwmp 2904 5 be be VB cord-015306-us58wwmp 2904 6 applicable applicable JJ cord-015306-us58wwmp 2904 7 in in IN cord-015306-us58wwmp 2904 8 neonates neonate NNS cord-015306-us58wwmp 2904 9 . . . cord-015306-us58wwmp 2905 1 Odillha Odillha NNP cord-015306-us58wwmp 2905 2 Morales Morales NNP cord-015306-us58wwmp 2905 3 Maglalang Maglalang NNP cord-015306-us58wwmp 2905 4 - - HYPH cord-015306-us58wwmp 2905 5 Reed Reed NNP cord-015306-us58wwmp 2905 6 Nephrology Nephrology NNP cord-015306-us58wwmp 2905 7 , , , cord-015306-us58wwmp 2905 8 Philippine Philippine NNP cord-015306-us58wwmp 2905 9 Children Children NNP cord-015306-us58wwmp 2905 10 's 's POS cord-015306-us58wwmp 2905 11 Medical Medical NNP cord-015306-us58wwmp 2905 12 Center Center NNP cord-015306-us58wwmp 2905 13 , , , cord-015306-us58wwmp 2905 14 Quezon Quezon NNP cord-015306-us58wwmp 2905 15 City City NNP cord-015306-us58wwmp 2905 16 , , , cord-015306-us58wwmp 2906 1 Philippines Philippines NNP cord-015306-us58wwmp 2906 2 Objective Objective NNP cord-015306-us58wwmp 2906 3 : : : cord-015306-us58wwmp 2907 1 The the DT cord-015306-us58wwmp 2907 2 precise precise JJ cord-015306-us58wwmp 2907 3 mechanism mechanism NN cord-015306-us58wwmp 2907 4 of of IN cord-015306-us58wwmp 2907 5 renal renal JJ cord-015306-us58wwmp 2907 6 injury injury NN cord-015306-us58wwmp 2907 7 among among IN cord-015306-us58wwmp 2907 8 Dengue dengue NN cord-015306-us58wwmp 2907 9 patients patient NNS cord-015306-us58wwmp 2907 10 is be VBZ cord-015306-us58wwmp 2907 11 not not RB cord-015306-us58wwmp 2907 12 known know VBN cord-015306-us58wwmp 2907 13 . . . cord-015306-us58wwmp 2908 1 Patients patient NNS cord-015306-us58wwmp 2908 2 who who WP cord-015306-us58wwmp 2908 3 have have VBP cord-015306-us58wwmp 2908 4 ATN ATN NNP cord-015306-us58wwmp 2908 5 will will MD cord-015306-us58wwmp 2908 6 usually usually RB cord-015306-us58wwmp 2908 7 require require VB cord-015306-us58wwmp 2908 8 early early JJ cord-015306-us58wwmp 2908 9 dialysis dialysis NN cord-015306-us58wwmp 2908 10 . . . cord-015306-us58wwmp 2909 1 However however RB cord-015306-us58wwmp 2909 2 , , , cord-015306-us58wwmp 2909 3 on on IN cord-015306-us58wwmp 2909 4 admission admission NN cord-015306-us58wwmp 2909 5 to to IN cord-015306-us58wwmp 2909 6 the the DT cord-015306-us58wwmp 2909 7 hospital hospital NN cord-015306-us58wwmp 2909 8 , , , cord-015306-us58wwmp 2909 9 it -PRON- PRP cord-015306-us58wwmp 2909 10 is be VBZ cord-015306-us58wwmp 2909 11 difficult difficult JJ cord-015306-us58wwmp 2909 12 to to TO cord-015306-us58wwmp 2909 13 distinguish distinguish VB cord-015306-us58wwmp 2909 14 DSS DSS NNP cord-015306-us58wwmp 2909 15 patients patient NNS cord-015306-us58wwmp 2909 16 with with IN cord-015306-us58wwmp 2909 17 ATN ATN NNP cord-015306-us58wwmp 2909 18 from from IN cord-015306-us58wwmp 2909 19 patients patient NNS cord-015306-us58wwmp 2909 20 with with IN cord-015306-us58wwmp 2909 21 reversible reversible JJ cord-015306-us58wwmp 2909 22 prerenal prerenal JJ cord-015306-us58wwmp 2909 23 causes cause NNS cord-015306-us58wwmp 2909 24 that that WDT cord-015306-us58wwmp 2909 25 will will MD cord-015306-us58wwmp 2909 26 respond respond VB cord-015306-us58wwmp 2909 27 to to IN cord-015306-us58wwmp 2909 28 simple simple JJ cord-015306-us58wwmp 2909 29 hydration hydration NN cord-015306-us58wwmp 2909 30 . . . cord-015306-us58wwmp 2910 1 Our -PRON- PRP$ cord-015306-us58wwmp 2910 2 understanding understanding NN cord-015306-us58wwmp 2910 3 of of IN cord-015306-us58wwmp 2910 4 the the DT cord-015306-us58wwmp 2910 5 complex complex JJ cord-015306-us58wwmp 2910 6 pathogenesis pathogenesis NN cord-015306-us58wwmp 2910 7 of of IN cord-015306-us58wwmp 2910 8 tubular tubular JJ cord-015306-us58wwmp 2910 9 injury injury NN cord-015306-us58wwmp 2910 10 in in IN cord-015306-us58wwmp 2910 11 Dengue Dengue NNP cord-015306-us58wwmp 2910 12 AKI AKI NNP cord-015306-us58wwmp 2910 13 is be VBZ cord-015306-us58wwmp 2910 14 very very RB cord-015306-us58wwmp 2910 15 limited limited JJ cord-015306-us58wwmp 2910 16 that that IN cord-015306-us58wwmp 2910 17 until until IN cord-015306-us58wwmp 2910 18 it -PRON- PRP cord-015306-us58wwmp 2910 19 is be VBZ cord-015306-us58wwmp 2910 20 sufficiently sufficiently RB cord-015306-us58wwmp 2910 21 increased increase VBN cord-015306-us58wwmp 2910 22 , , , cord-015306-us58wwmp 2910 23 therapeutic therapeutic JJ cord-015306-us58wwmp 2910 24 strategies strategy NNS cord-015306-us58wwmp 2910 25 will will MD cord-015306-us58wwmp 2910 26 continue continue VB cord-015306-us58wwmp 2910 27 to to TO cord-015306-us58wwmp 2910 28 fail fail VB cord-015306-us58wwmp 2910 29 . . . cord-015306-us58wwmp 2911 1 Therefore therefore RB cord-015306-us58wwmp 2911 2 we -PRON- PRP cord-015306-us58wwmp 2911 3 sought seek VBD cord-015306-us58wwmp 2911 4 to to TO cord-015306-us58wwmp 2911 5 explore explore VB cord-015306-us58wwmp 2911 6 the the DT cord-015306-us58wwmp 2911 7 limitations limitation NNS cord-015306-us58wwmp 2911 8 of of IN cord-015306-us58wwmp 2911 9 serum serum NN cord-015306-us58wwmp 2911 10 creatinine creatinine NN cord-015306-us58wwmp 2911 11 in in IN cord-015306-us58wwmp 2911 12 this this DT cord-015306-us58wwmp 2911 13 setting setting NN cord-015306-us58wwmp 2911 14 . . . cord-015306-us58wwmp 2912 1 General general JJ cord-015306-us58wwmp 2912 2 objective objective NN cord-015306-us58wwmp 2912 3 is be VBZ cord-015306-us58wwmp 2912 4 to to TO cord-015306-us58wwmp 2912 5 determine determine VB cord-015306-us58wwmp 2912 6 the the DT cord-015306-us58wwmp 2912 7 clinical clinical JJ cord-015306-us58wwmp 2912 8 and and CC cord-015306-us58wwmp 2912 9 diagnostic diagnostic JJ cord-015306-us58wwmp 2912 10 factors factor NNS cord-015306-us58wwmp 2912 11 which which WDT cord-015306-us58wwmp 2912 12 are be VBP cord-015306-us58wwmp 2912 13 predictive predictive JJ cord-015306-us58wwmp 2912 14 for for IN cord-015306-us58wwmp 2912 15 the the DT cord-015306-us58wwmp 2912 16 need need NN cord-015306-us58wwmp 2912 17 for for IN cord-015306-us58wwmp 2912 18 dialysis dialysis NN cord-015306-us58wwmp 2912 19 among among IN cord-015306-us58wwmp 2912 20 DSS DSS NNP cord-015306-us58wwmp 2912 21 patients patient NNS cord-015306-us58wwmp 2912 22 at at IN cord-015306-us58wwmp 2912 23 PCMC PCMC NNP cord-015306-us58wwmp 2912 24 . . . cord-015306-us58wwmp 2913 1 Specific specific JJ cord-015306-us58wwmp 2913 2 objective objective NN cord-015306-us58wwmp 2913 3 is be VBZ cord-015306-us58wwmp 2913 4 to to TO cord-015306-us58wwmp 2913 5 determine determine VB cord-015306-us58wwmp 2913 6 if if IN cord-015306-us58wwmp 2913 7 the the DT cord-015306-us58wwmp 2913 8 following following JJ cord-015306-us58wwmp 2913 9 factors factor NNS cord-015306-us58wwmp 2913 10 are be VBP cord-015306-us58wwmp 2913 11 predictive predictive JJ cord-015306-us58wwmp 2913 12 of of IN cord-015306-us58wwmp 2913 13 the the DT cord-015306-us58wwmp 2913 14 need need NN cord-015306-us58wwmp 2913 15 for for IN cord-015306-us58wwmp 2913 16 dialysis dialysis NN cord-015306-us58wwmp 2913 17 : : : cord-015306-us58wwmp 2913 18 decrease decrease NN cord-015306-us58wwmp 2913 19 in in IN cord-015306-us58wwmp 2913 20 estimated estimate VBN cord-015306-us58wwmp 2913 21 creatinine creatinine NN cord-015306-us58wwmp 2913 22 clearance clearance NN cord-015306-us58wwmp 2913 23 by by IN cord-015306-us58wwmp 2913 24 75 75 CD cord-015306-us58wwmp 2913 25 % % NN cord-015306-us58wwmp 2913 26 or or CC cord-015306-us58wwmp 2913 27 < < XX cord-015306-us58wwmp 2913 28 35 35 CD cord-015306-us58wwmp 2913 29 ml ml NNS cord-015306-us58wwmp 2913 30 / / SYM cord-015306-us58wwmp 2913 31 min min NNP cord-015306-us58wwmp 2913 32 / / SYM cord-015306-us58wwmp 2913 33 BSA BSA NNP cord-015306-us58wwmp 2913 34 with with IN cord-015306-us58wwmp 2913 35 urine urine NN cord-015306-us58wwmp 2913 36 output output NN cord-015306-us58wwmp 2913 37 of of IN cord-015306-us58wwmp 2913 38 < < XX cord-015306-us58wwmp 2913 39 0.3ml 0.3ml CD cord-015306-us58wwmp 2913 40 / / SYM cord-015306-us58wwmp 2913 41 kg kg NNP cord-015306-us58wwmp 2913 42 / / SYM cord-015306-us58wwmp 2913 43 hr hr NN cord-015306-us58wwmp 2913 44 . . . cord-015306-us58wwmp 2914 1 X X NNS cord-015306-us58wwmp 2915 1 24 24 CD cord-015306-us58wwmp 2915 2 hours hour NNS cord-015306-us58wwmp 2915 3 or or CC cord-015306-us58wwmp 2915 4 anuria anuria NN cord-015306-us58wwmp 2915 5 of of IN cord-015306-us58wwmp 2915 6 12 12 CD cord-015306-us58wwmp 2915 7 hours hour NNS cord-015306-us58wwmp 2915 8 , , , cord-015306-us58wwmp 2915 9 assess assess VB cord-015306-us58wwmp 2915 10 the the DT cord-015306-us58wwmp 2915 11 usefulness usefulness NN cord-015306-us58wwmp 2915 12 of of IN cord-015306-us58wwmp 2915 13 urinary urinary JJ cord-015306-us58wwmp 2915 14 sediment sediment NN cord-015306-us58wwmp 2915 15 scoring scoring NN cord-015306-us58wwmp 2915 16 ( ( -LRB- cord-015306-us58wwmp 2915 17 USS USS NNP cord-015306-us58wwmp 2915 18 ) ) -RRB- cord-015306-us58wwmp 2915 19 in in IN cord-015306-us58wwmp 2915 20 predicting predict VBG cord-015306-us58wwmp 2915 21 the the DT cord-015306-us58wwmp 2915 22 need need NN cord-015306-us58wwmp 2915 23 for for IN cord-015306-us58wwmp 2915 24 dialysis dialysis NN cord-015306-us58wwmp 2915 25 , , , cord-015306-us58wwmp 2915 26 Methods method NNS cord-015306-us58wwmp 2915 27 : : : cord-015306-us58wwmp 2916 1 This this DT cord-015306-us58wwmp 2916 2 retrospective retrospective JJ cord-015306-us58wwmp 2916 3 study study NN cord-015306-us58wwmp 2916 4 covered cover VBD cord-015306-us58wwmp 2916 5 60 60 CD cord-015306-us58wwmp 2916 6 newly newly RB cord-015306-us58wwmp 2916 7 admitted admit VBN cord-015306-us58wwmp 2916 8 cases case NNS cord-015306-us58wwmp 2916 9 of of IN cord-015306-us58wwmp 2916 10 Dengue Dengue NNP cord-015306-us58wwmp 2916 11 Shock Shock NNP cord-015306-us58wwmp 2916 12 Syndrome Syndrome NNP cord-015306-us58wwmp 2916 13 lll lll NNP cord-015306-us58wwmp 2916 14 and and CC cord-015306-us58wwmp 2916 15 lV lV NNP cord-015306-us58wwmp 2916 16 at at IN cord-015306-us58wwmp 2916 17 the the DT cord-015306-us58wwmp 2916 18 Philippine Philippine NNP cord-015306-us58wwmp 2916 19 Children Children NNPS cord-015306-us58wwmp 2916 20 's 's POS cord-015306-us58wwmp 2916 21 Medical Medical NNP cord-015306-us58wwmp 2916 22 Center Center NNP cord-015306-us58wwmp 2916 23 between between IN cord-015306-us58wwmp 2916 24 January January NNP cord-015306-us58wwmp 2916 25 2010 2010 CD cord-015306-us58wwmp 2916 26 to to IN cord-015306-us58wwmp 2916 27 December December NNP cord-015306-us58wwmp 2916 28 2011 2011 CD cord-015306-us58wwmp 2916 29 . . . cord-015306-us58wwmp 2917 1 Results result NNS cord-015306-us58wwmp 2917 2 : : : cord-015306-us58wwmp 2918 1 Data datum NNS cord-015306-us58wwmp 2918 2 from from IN cord-015306-us58wwmp 2918 3 60 60 CD cord-015306-us58wwmp 2918 4 patients patient NNS cord-015306-us58wwmp 2918 5 were be VBD cord-015306-us58wwmp 2918 6 available available JJ cord-015306-us58wwmp 2918 7 for for IN cord-015306-us58wwmp 2918 8 analysis analysis NN cord-015306-us58wwmp 2918 9 . . . cord-015306-us58wwmp 2919 1 Comparison comparison NN cord-015306-us58wwmp 2919 2 of of IN cord-015306-us58wwmp 2919 3 the the DT cord-015306-us58wwmp 2919 4 demographic demographic JJ cord-015306-us58wwmp 2919 5 characteristics characteristic NNS cord-015306-us58wwmp 2919 6 between between IN cord-015306-us58wwmp 2919 7 patients patient NNS cord-015306-us58wwmp 2919 8 who who WP cord-015306-us58wwmp 2919 9 required require VBD cord-015306-us58wwmp 2919 10 dialysis dialysis NN cord-015306-us58wwmp 2919 11 and and CC cord-015306-us58wwmp 2919 12 those those DT cord-015306-us58wwmp 2919 13 who who WP cord-015306-us58wwmp 2919 14 did do VBD cord-015306-us58wwmp 2919 15 not not RB cord-015306-us58wwmp 2919 16 showed show VBN cord-015306-us58wwmp 2919 17 no no DT cord-015306-us58wwmp 2919 18 significant significant JJ cord-015306-us58wwmp 2919 19 difference difference NN cord-015306-us58wwmp 2919 20 as as IN cord-015306-us58wwmp 2919 21 proven prove VBN cord-015306-us58wwmp 2919 22 by by IN cord-015306-us58wwmp 2919 23 all all DT cord-015306-us58wwmp 2919 24 p p NN cord-015306-us58wwmp 2919 25 values value NNS cord-015306-us58wwmp 2919 26 > > XX cord-015306-us58wwmp 2919 27 0.05 0.05 CD cord-015306-us58wwmp 2919 28 . . . cord-015306-us58wwmp 2920 1 Of of IN cord-015306-us58wwmp 2920 2 the the DT cord-015306-us58wwmp 2920 3 differentclinical differentclinical JJ cord-015306-us58wwmp 2920 4 and and CC cord-015306-us58wwmp 2920 5 laboratory laboratory NN cord-015306-us58wwmp 2920 6 parameters parameter NNS cord-015306-us58wwmp 2920 7 , , , cord-015306-us58wwmp 2920 8 there there EX cord-015306-us58wwmp 2920 9 was be VBD cord-015306-us58wwmp 2920 10 a a DT cord-015306-us58wwmp 2920 11 significant significant JJ cord-015306-us58wwmp 2920 12 difference difference NN cord-015306-us58wwmp 2920 13 in in IN cord-015306-us58wwmp 2920 14 the the DT cord-015306-us58wwmp 2920 15 HR hr NN cord-015306-us58wwmp 2920 16 , , , cord-015306-us58wwmp 2920 17 RR RR NNP cord-015306-us58wwmp 2920 18 , , , cord-015306-us58wwmp 2920 19 O o NN cord-015306-us58wwmp 2920 20 2 2 CD cord-015306-us58wwmp 2920 21 saturation saturation NN cord-015306-us58wwmp 2920 22 , , , cord-015306-us58wwmp 2920 23 bicarbonate bicarbonate NN cord-015306-us58wwmp 2920 24 and and CC cord-015306-us58wwmp 2920 25 base base NN cord-015306-us58wwmp 2920 26 excess excess NN cord-015306-us58wwmp 2920 27 as as IN cord-015306-us58wwmp 2920 28 proven prove VBN cord-015306-us58wwmp 2920 29 by by IN cord-015306-us58wwmp 2920 30 all all DT cord-015306-us58wwmp 2920 31 p p NN cord-015306-us58wwmp 2920 32 values value NNS cord-015306-us58wwmp 2920 33 < < XX cord-015306-us58wwmp 2920 34 0.05 0.05 CD cord-015306-us58wwmp 2920 35 . . . cord-015306-us58wwmp 2921 1 The the DT cord-015306-us58wwmp 2921 2 HR HR NNP cord-015306-us58wwmp 2921 3 an an DT cord-015306-us58wwmp 2921 4 RR rr NN cord-015306-us58wwmp 2921 5 were be VBD cord-015306-us58wwmp 2921 6 significantly significantly RB cord-015306-us58wwmp 2921 7 higher high JJR cord-015306-us58wwmp 2921 8 among among IN cord-015306-us58wwmp 2921 9 those those DT cord-015306-us58wwmp 2921 10 who who WP cord-015306-us58wwmp 2921 11 needed need VBD cord-015306-us58wwmp 2921 12 dialysis dialysis NN cord-015306-us58wwmp 2921 13 than than IN cord-015306-us58wwmp 2921 14 those those DT cord-015306-us58wwmp 2921 15 who who WP cord-015306-us58wwmp 2921 16 did do VBD cord-015306-us58wwmp 2921 17 not not RB cord-015306-us58wwmp 2921 18 O o NN cord-015306-us58wwmp 2921 19 2 2 CD cord-015306-us58wwmp 2921 20 saturation saturation NN cord-015306-us58wwmp 2921 21 , , , cord-015306-us58wwmp 2921 22 bicarbonate bicarbonate NN cord-015306-us58wwmp 2921 23 and and CC cord-015306-us58wwmp 2921 24 base base NN cord-015306-us58wwmp 2921 25 excess excess NN cord-015306-us58wwmp 2921 26 were be VBD cord-015306-us58wwmp 2921 27 significantly significantly RB cord-015306-us58wwmp 2921 28 lower low JJR cord-015306-us58wwmp 2921 29 among among IN cord-015306-us58wwmp 2921 30 those those DT cord-015306-us58wwmp 2921 31 who who WP cord-015306-us58wwmp 2921 32 needed need VBD cord-015306-us58wwmp 2921 33 dialysis dialysis NN cord-015306-us58wwmp 2921 34 than than IN cord-015306-us58wwmp 2921 35 those those DT cord-015306-us58wwmp 2921 36 who who WP cord-015306-us58wwmp 2921 37 did do VBD cord-015306-us58wwmp 2921 38 not not RB cord-015306-us58wwmp 2921 39 . . . cord-015306-us58wwmp 2922 1 The the DT cord-015306-us58wwmp 2922 2 estimated estimate VBN cord-015306-us58wwmp 2922 3 creatinine creatinine NN cord-015306-us58wwmp 2922 4 clearance clearance NN cord-015306-us58wwmp 2922 5 was be VBD cord-015306-us58wwmp 2922 6 significantly significantly RB cord-015306-us58wwmp 2922 7 lower low JJR cord-015306-us58wwmp 2922 8 among among IN cord-015306-us58wwmp 2922 9 those those DT cord-015306-us58wwmp 2922 10 who who WP cord-015306-us58wwmp 2922 11 needed need VBD cord-015306-us58wwmp 2922 12 dialysis dialysis NN cord-015306-us58wwmp 2922 13 than than IN cord-015306-us58wwmp 2922 14 those those DT cord-015306-us58wwmp 2922 15 who who WP cord-015306-us58wwmp 2922 16 did do VBD cord-015306-us58wwmp 2922 17 not not RB cord-015306-us58wwmp 2922 18 . . . cord-015306-us58wwmp 2923 1 Urine urine NN cord-015306-us58wwmp 2923 2 sediment sediment NN cord-015306-us58wwmp 2923 3 score score NN cord-015306-us58wwmp 2923 4 ( ( -LRB- cord-015306-us58wwmp 2923 5 USS USS NNP cord-015306-us58wwmp 2923 6 ) ) -RRB- cord-015306-us58wwmp 2924 1 ≥3 ≥3 NNP cord-015306-us58wwmp 2924 2 was be VBD cord-015306-us58wwmp 2924 3 significantly significantly RB cord-015306-us58wwmp 2924 4 higher high JJR cord-015306-us58wwmp 2924 5 among among IN cord-015306-us58wwmp 2924 6 those those DT cord-015306-us58wwmp 2924 7 who who WP cord-015306-us58wwmp 2924 8 needed need VBD cord-015306-us58wwmp 2924 9 dialysis dialysis NN cord-015306-us58wwmp 2924 10 than than IN cord-015306-us58wwmp 2924 11 those those DT cord-015306-us58wwmp 2924 12 who who WP cord-015306-us58wwmp 2924 13 did do VBD cord-015306-us58wwmp 2924 14 not not RB cord-015306-us58wwmp 2924 15 . . . cord-015306-us58wwmp 2925 1 Conclusion conclusion NN cord-015306-us58wwmp 2925 2 : : : cord-015306-us58wwmp 2926 1 Our -PRON- PRP$ cord-015306-us58wwmp 2926 2 data datum NNS cord-015306-us58wwmp 2926 3 indicate indicate VBP cord-015306-us58wwmp 2926 4 that that IN cord-015306-us58wwmp 2926 5 a a DT cord-015306-us58wwmp 2926 6 decrease decrease NN cord-015306-us58wwmp 2926 7 in in IN cord-015306-us58wwmp 2926 8 estimated estimate VBN cord-015306-us58wwmp 2926 9 creatinine creatinine NN cord-015306-us58wwmp 2926 10 clearance clearance NN cord-015306-us58wwmp 2926 11 by by IN cord-015306-us58wwmp 2926 12 75 75 CD cord-015306-us58wwmp 2926 13 % % NN cord-015306-us58wwmp 2926 14 or or CC cord-015306-us58wwmp 2926 15 < < XX cord-015306-us58wwmp 2926 16 35 35 CD cord-015306-us58wwmp 2926 17 ml ml NNS cord-015306-us58wwmp 2926 18 / / SYM cord-015306-us58wwmp 2926 19 min min NNP cord-015306-us58wwmp 2926 20 / / SYM cord-015306-us58wwmp 2926 21 BSA BSA NNP cord-015306-us58wwmp 2926 22 with with IN cord-015306-us58wwmp 2926 23 urine urine NN cord-015306-us58wwmp 2926 24 output output NN cord-015306-us58wwmp 2926 25 of of IN cord-015306-us58wwmp 2926 26 < < XX cord-015306-us58wwmp 2926 27 0.3ml 0.3ml CD cord-015306-us58wwmp 2926 28 / / SYM cord-015306-us58wwmp 2926 29 kg kg NNP cord-015306-us58wwmp 2926 30 / / SYM cord-015306-us58wwmp 2926 31 hr hr NN cord-015306-us58wwmp 2926 32 . . . cord-015306-us58wwmp 2927 1 X X NNS cord-015306-us58wwmp 2928 1 24 24 CD cord-015306-us58wwmp 2928 2 hours hour NNS cord-015306-us58wwmp 2928 3 or or CC cord-015306-us58wwmp 2928 4 anuria anuria NN cord-015306-us58wwmp 2928 5 of of IN cord-015306-us58wwmp 2928 6 12 12 CD cord-015306-us58wwmp 2928 7 hours hour NNS cord-015306-us58wwmp 2928 8 is be VBZ cord-015306-us58wwmp 2928 9 not not RB cord-015306-us58wwmp 2928 10 predictive predictive JJ cord-015306-us58wwmp 2928 11 of of IN cord-015306-us58wwmp 2928 12 dialysis dialysis NN cord-015306-us58wwmp 2928 13 among among IN cord-015306-us58wwmp 2928 14 DSS DSS NNP cord-015306-us58wwmp 2928 15 - - HYPH cord-015306-us58wwmp 2928 16 induced induce VBN cord-015306-us58wwmp 2928 17 AKI AKI NNP cord-015306-us58wwmp 2928 18 as as RB cord-015306-us58wwmp 2928 19 well well RB cord-015306-us58wwmp 2928 20 as as IN cord-015306-us58wwmp 2928 21 other other JJ cord-015306-us58wwmp 2928 22 clinical clinical JJ cord-015306-us58wwmp 2928 23 and and CC cord-015306-us58wwmp 2928 24 laboratory laboratory NN cord-015306-us58wwmp 2928 25 indices index NNS cord-015306-us58wwmp 2928 26 . . . cord-015306-us58wwmp 2929 1 But but CC cord-015306-us58wwmp 2929 2 rather rather RB cord-015306-us58wwmp 2929 3 , , , cord-015306-us58wwmp 2929 4 relatively relatively RB cord-015306-us58wwmp 2929 5 lower low JJR cord-015306-us58wwmp 2929 6 serum serum NN cord-015306-us58wwmp 2929 7 creatinine creatinine NN cord-015306-us58wwmp 2929 8 level level NN cord-015306-us58wwmp 2929 9 among among IN cord-015306-us58wwmp 2929 10 DSSinduced dssinduce VBN cord-015306-us58wwmp 2929 11 AKI AKI NNP cord-015306-us58wwmp 2929 12 who who WP cord-015306-us58wwmp 2929 13 needed need VBD cord-015306-us58wwmp 2929 14 dialysis dialysis NN cord-015306-us58wwmp 2929 15 is be VBZ cord-015306-us58wwmp 2929 16 associated associate VBN cord-015306-us58wwmp 2929 17 with with IN cord-015306-us58wwmp 2929 18 greater great JJR cord-015306-us58wwmp 2929 19 urine urine NN cord-015306-us58wwmp 2929 20 sediment sediment NN cord-015306-us58wwmp 2929 21 scorecompared scorecompare VBN cord-015306-us58wwmp 2929 22 with with IN cord-015306-us58wwmp 2929 23 those those DT cord-015306-us58wwmp 2929 24 who who WP cord-015306-us58wwmp 2929 25 did do VBD cord-015306-us58wwmp 2929 26 not not RB cord-015306-us58wwmp 2929 27 . . . cord-015306-us58wwmp 2930 1 A a DT cord-015306-us58wwmp 2930 2 USS USS NNP cord-015306-us58wwmp 2930 3 ≥ ≥ NNP cord-015306-us58wwmp 2930 4 3 3 CD cord-015306-us58wwmp 2930 5 correlated correlate VBD cord-015306-us58wwmp 2930 6 with with IN cord-015306-us58wwmp 2930 7 ATN ATN NNP cord-015306-us58wwmp 2930 8 and and CC cord-015306-us58wwmp 2930 9 was be VBD cord-015306-us58wwmp 2930 10 predictive predictive JJ cord-015306-us58wwmp 2930 11 of of IN cord-015306-us58wwmp 2930 12 early early JJ cord-015306-us58wwmp 2930 13 dialysis dialysis NN cord-015306-us58wwmp 2930 14 . . . cord-015306-us58wwmp 2931 1 However however RB cord-015306-us58wwmp 2931 2 , , , cord-015306-us58wwmp 2931 3 estimated estimate VBN cord-015306-us58wwmp 2931 4 crea crea NNP cord-015306-us58wwmp 2931 5 < < XX cord-015306-us58wwmp 2931 6 50 50 CD cord-015306-us58wwmp 2931 7 is be VBZ cord-015306-us58wwmp 2931 8 the the DT cord-015306-us58wwmp 2931 9 only only JJ cord-015306-us58wwmp 2931 10 factor factor NN cord-015306-us58wwmp 2931 11 predictive predictive NN cord-015306-us58wwmp 2931 12 of of IN cord-015306-us58wwmp 2931 13 dialysis dialysis NN cord-015306-us58wwmp 2931 14 , , , cord-015306-us58wwmp 2931 15 since since IN cord-015306-us58wwmp 2931 16 this this DT cord-015306-us58wwmp 2931 17 is be VBZ cord-015306-us58wwmp 2931 18 the the DT cord-015306-us58wwmp 2931 19 only only JJ cord-015306-us58wwmp 2931 20 one one CD cord-015306-us58wwmp 2931 21 that that WDT cord-015306-us58wwmp 2931 22 was be VBD cord-015306-us58wwmp 2931 23 positive positive JJ cord-015306-us58wwmp 2931 24 after after IN cord-015306-us58wwmp 2931 25 logistic logistic JJ cord-015306-us58wwmp 2931 26 regression regression NN cord-015306-us58wwmp 2931 27 . . . cord-015306-us58wwmp 2932 1 Abstract abstract JJ cord-015306-us58wwmp 2932 2 # # NN cord-015306-us58wwmp 2933 1 P p NN cord-015306-us58wwmp 2933 2 - - HYPH cord-015306-us58wwmp 2933 3 SAT327 SAT327 NNP cord-015306-us58wwmp 2934 1 Pre pre JJ cord-015306-us58wwmp 2934 2 - - JJ cord-015306-us58wwmp 2934 3 operative operative JJ cord-015306-us58wwmp 2934 4 FGF23 FGF23 NNP cord-015306-us58wwmp 2934 5 predicts predict VBZ cord-015306-us58wwmp 2934 6 acute acute JJ cord-015306-us58wwmp 2934 7 kidney kidney NN cord-015306-us58wwmp 2934 8 injury injury NN cord-015306-us58wwmp 2934 9 in in IN cord-015306-us58wwmp 2934 10 pediatric pediatric JJ cord-015306-us58wwmp 2934 11 cardiac cardiac JJ cord-015306-us58wwmp 2934 12 surgery surgery NN cord-015306-us58wwmp 2934 13 patients patient NNS cord-015306-us58wwmp 2934 14 : : : cord-015306-us58wwmp 2934 15 a a DT cord-015306-us58wwmp 2934 16 prospective prospective JJ cord-015306-us58wwmp 2934 17 study study NN cord-015306-us58wwmp 2934 18 Mark Mark NNP cord-015306-us58wwmp 2934 19 R R NNP cord-015306-us58wwmp 2934 20 Hanudel Hanudel NNP cord-015306-us58wwmp 2934 21 , , , cord-015306-us58wwmp 2934 22 Myke Myke NNP cord-015306-us58wwmp 2934 23 Federman Federman NNP cord-015306-us58wwmp 2934 24 , , , cord-015306-us58wwmp 2934 25 Barbara Barbara NNP cord-015306-us58wwmp 2934 26 Gales Gales NNP cord-015306-us58wwmp 2934 27 , , , cord-015306-us58wwmp 2934 28 Georgina Georgina NNP cord-015306-us58wwmp 2934 29 Ramos Ramos NNP cord-015306-us58wwmp 2934 30 , , , cord-015306-us58wwmp 2934 31 Vicky Vicky NNP cord-015306-us58wwmp 2934 32 Campbell Campbell NNP cord-015306-us58wwmp 2934 33 , , , cord-015306-us58wwmp 2934 34 Kristen Kristen NNP cord-015306-us58wwmp 2934 35 Ethridge Ethridge NNP cord-015306-us58wwmp 2934 36 , , , cord-015306-us58wwmp 2934 37 Mary Mary NNP cord-015306-us58wwmp 2934 38 Scotti Scotti NNP cord-015306-us58wwmp 2934 39 , , , cord-015306-us58wwmp 2934 40 Brian Brian NNP cord-015306-us58wwmp 2934 41 Reemtsen Reemtsen NNP cord-015306-us58wwmp 2934 42 , , , cord-015306-us58wwmp 2934 43 Isidro Isidro NNP cord-015306-us58wwmp 2934 44 B B NNP cord-015306-us58wwmp 2934 45 Salusky Salusky NNP cord-015306-us58wwmp 2934 46 , , , cord-015306-us58wwmp 2934 47 Katherine Katherine NNP cord-015306-us58wwmp 2934 48 Wesseling Wesseling NNP cord-015306-us58wwmp 2934 49 - - HYPH cord-015306-us58wwmp 2934 50 Perry Perry NNP cord-015306-us58wwmp 2934 51 Pediatrics Pediatrics NNP cord-015306-us58wwmp 2934 52 , , , cord-015306-us58wwmp 2934 53 UCLA UCLA NNP cord-015306-us58wwmp 2934 54 , , , cord-015306-us58wwmp 2934 55 Los Los NNP cord-015306-us58wwmp 2934 56 Angeles Angeles NNP cord-015306-us58wwmp 2934 57 , , , cord-015306-us58wwmp 2934 58 USA USA NNP cord-015306-us58wwmp 2934 59 Objective Objective NNP cord-015306-us58wwmp 2934 60 : : : cord-015306-us58wwmp 2934 61 Fibroblast Fibroblast NNP cord-015306-us58wwmp 2934 62 growth growth NN cord-015306-us58wwmp 2934 63 factor factor NN cord-015306-us58wwmp 2934 64 23 23 CD cord-015306-us58wwmp 2935 1 ( ( -LRB- cord-015306-us58wwmp 2935 2 FGF23 fgf23 NN cord-015306-us58wwmp 2935 3 ) ) -RRB- cord-015306-us58wwmp 2935 4 is be VBZ cord-015306-us58wwmp 2935 5 a a DT cord-015306-us58wwmp 2935 6 phosphaturic phosphaturic JJ cord-015306-us58wwmp 2935 7 hormone hormone NN cord-015306-us58wwmp 2935 8 that that WDT cord-015306-us58wwmp 2935 9 predicts predict VBZ cord-015306-us58wwmp 2935 10 renal renal JJ cord-015306-us58wwmp 2935 11 disease disease NN cord-015306-us58wwmp 2935 12 progression progression NN cord-015306-us58wwmp 2935 13 in in IN cord-015306-us58wwmp 2935 14 CKD CKD NNP cord-015306-us58wwmp 2935 15 . . . cord-015306-us58wwmp 2936 1 However however RB cord-015306-us58wwmp 2936 2 , , , cord-015306-us58wwmp 2936 3 in in IN cord-015306-us58wwmp 2936 4 the the DT cord-015306-us58wwmp 2936 5 setting setting NN cord-015306-us58wwmp 2936 6 of of IN cord-015306-us58wwmp 2936 7 AKI AKI NNP cord-015306-us58wwmp 2936 8 , , , cord-015306-us58wwmp 2936 9 there there EX cord-015306-us58wwmp 2936 10 is be VBZ cord-015306-us58wwmp 2936 11 a a DT cord-015306-us58wwmp 2936 12 paucity paucity NN cord-015306-us58wwmp 2936 13 of of IN cord-015306-us58wwmp 2936 14 prospective prospective JJ cord-015306-us58wwmp 2936 15 data datum NNS cord-015306-us58wwmp 2936 16 on on IN cord-015306-us58wwmp 2936 17 FGF23 fgf23 NN cord-015306-us58wwmp 2936 18 , , , cord-015306-us58wwmp 2936 19 especially especially RB cord-015306-us58wwmp 2936 20 in in IN cord-015306-us58wwmp 2936 21 the the DT cord-015306-us58wwmp 2936 22 pediatric pediatric JJ cord-015306-us58wwmp 2936 23 population population NN cord-015306-us58wwmp 2936 24 . . . cord-015306-us58wwmp 2937 1 Thus thus RB cord-015306-us58wwmp 2937 2 , , , cord-015306-us58wwmp 2937 3 we -PRON- PRP cord-015306-us58wwmp 2937 4 prospectively prospectively RB cord-015306-us58wwmp 2937 5 measured measure VBD cord-015306-us58wwmp 2937 6 FGF23 fgf23 NN cord-015306-us58wwmp 2937 7 levels level NNS cord-015306-us58wwmp 2937 8 in in IN cord-015306-us58wwmp 2937 9 pediatric pediatric JJ cord-015306-us58wwmp 2937 10 patients patient NNS cord-015306-us58wwmp 2937 11 undergoing undergo VBG cord-015306-us58wwmp 2937 12 cardiopulmonary cardiopulmonary JJ cord-015306-us58wwmp 2937 13 bypass bypass NN cord-015306-us58wwmp 2937 14 ( ( -LRB- cord-015306-us58wwmp 2937 15 CPB CPB NNP cord-015306-us58wwmp 2937 16 ) ) -RRB- cord-015306-us58wwmp 2937 17 and and CC cord-015306-us58wwmp 2937 18 assessed assess VBD cord-015306-us58wwmp 2937 19 the the DT cord-015306-us58wwmp 2937 20 ability ability NN cord-015306-us58wwmp 2937 21 of of IN cord-015306-us58wwmp 2937 22 FGF23 fgf23 NN cord-015306-us58wwmp 2937 23 to to TO cord-015306-us58wwmp 2937 24 predict predict VB cord-015306-us58wwmp 2937 25 AKI AKI NNP cord-015306-us58wwmp 2937 26 . . . cord-015306-us58wwmp 2938 1 Methods method NNS cord-015306-us58wwmp 2938 2 : : : cord-015306-us58wwmp 2938 3 Pediatric pediatric JJ cord-015306-us58wwmp 2938 4 patients patient NNS cord-015306-us58wwmp 2938 5 , , , cord-015306-us58wwmp 2938 6 age age NN cord-015306-us58wwmp 2938 7 newborn newborn JJ cord-015306-us58wwmp 2938 8 to to IN cord-015306-us58wwmp 2938 9 21 21 CD cord-015306-us58wwmp 2938 10 years year NNS cord-015306-us58wwmp 2938 11 , , , cord-015306-us58wwmp 2938 12 without without IN cord-015306-us58wwmp 2938 13 underlying underlie VBG cord-015306-us58wwmp 2938 14 CKD CKD NNP cord-015306-us58wwmp 2938 15 , , , cord-015306-us58wwmp 2938 16 undergoing undergo VBG cord-015306-us58wwmp 2938 17 cardiac cardiac JJ cord-015306-us58wwmp 2938 18 surgery surgery NN cord-015306-us58wwmp 2938 19 requiring require VBG cord-015306-us58wwmp 2938 20 CPB CPB NNP cord-015306-us58wwmp 2938 21 were be VBD cord-015306-us58wwmp 2938 22 eligible eligible JJ cord-015306-us58wwmp 2938 23 for for IN cord-015306-us58wwmp 2938 24 the the DT cord-015306-us58wwmp 2938 25 study study NN cord-015306-us58wwmp 2938 26 . . . cord-015306-us58wwmp 2939 1 Plasma plasma NN cord-015306-us58wwmp 2939 2 FGF23 fgf23 NN cord-015306-us58wwmp 2939 3 levels level NNS cord-015306-us58wwmp 2939 4 ( ( -LRB- cord-015306-us58wwmp 2939 5 2nd 2nd JJ cord-015306-us58wwmp 2939 6 generation generation NN cord-015306-us58wwmp 2939 7 Cterminal Cterminal NNP cord-015306-us58wwmp 2939 8 , , , cord-015306-us58wwmp 2939 9 Immunotopics Immunotopics NNP cord-015306-us58wwmp 2939 10 ) ) -RRB- cord-015306-us58wwmp 2939 11 were be VBD cord-015306-us58wwmp 2939 12 measured measure VBN cord-015306-us58wwmp 2939 13 pre pre JJ cord-015306-us58wwmp 2939 14 - - JJ cord-015306-us58wwmp 2939 15 operatively operatively RB cord-015306-us58wwmp 2939 16 and and CC cord-015306-us58wwmp 2939 17 at at IN cord-015306-us58wwmp 2939 18 2 2 CD cord-015306-us58wwmp 2939 19 , , , cord-015306-us58wwmp 2939 20 6 6 CD cord-015306-us58wwmp 2939 21 , , , cord-015306-us58wwmp 2939 22 12 12 CD cord-015306-us58wwmp 2939 23 , , , cord-015306-us58wwmp 2939 24 24 24 CD cord-015306-us58wwmp 2939 25 , , , cord-015306-us58wwmp 2939 26 48 48 CD cord-015306-us58wwmp 2939 27 , , , cord-015306-us58wwmp 2939 28 and and CC cord-015306-us58wwmp 2939 29 96 96 CD cord-015306-us58wwmp 2939 30 hours hour NNS cord-015306-us58wwmp 2939 31 post post NN cord-015306-us58wwmp 2939 32 - - NN cord-015306-us58wwmp 2939 33 reperfusion reperfusion NN cord-015306-us58wwmp 2939 34 . . . cord-015306-us58wwmp 2940 1 Serum serum NN cord-015306-us58wwmp 2940 2 creatinine creatinine NN cord-015306-us58wwmp 2940 3 was be VBD cord-015306-us58wwmp 2940 4 obtained obtain VBN cord-015306-us58wwmp 2940 5 at at IN cord-015306-us58wwmp 2940 6 baseline baseline NN cord-015306-us58wwmp 2940 7 and and CC cord-015306-us58wwmp 2940 8 daily daily JJ cord-015306-us58wwmp 2940 9 post post JJ cord-015306-us58wwmp 2940 10 - - NN cord-015306-us58wwmp 2940 11 reperfusion reperfusion NN cord-015306-us58wwmp 2940 12 . . . cord-015306-us58wwmp 2941 1 AKI AKI NNP cord-015306-us58wwmp 2941 2 was be VBD cord-015306-us58wwmp 2941 3 defined define VBN cord-015306-us58wwmp 2941 4 by by IN cord-015306-us58wwmp 2941 5 the the DT cord-015306-us58wwmp 2941 6 AKIN akin NN cord-015306-us58wwmp 2941 7 criteria criterion NNS cord-015306-us58wwmp 2941 8 , , , cord-015306-us58wwmp 2941 9 estimated estimate VBN cord-015306-us58wwmp 2941 10 GFR GFR NNP cord-015306-us58wwmp 2941 11 was be VBD cord-015306-us58wwmp 2941 12 calculated calculate VBN cord-015306-us58wwmp 2941 13 using use VBG cord-015306-us58wwmp 2941 14 the the DT cord-015306-us58wwmp 2941 15 Schwartz Schwartz NNP cord-015306-us58wwmp 2941 16 formula formula NN cord-015306-us58wwmp 2941 17 , , , cord-015306-us58wwmp 2941 18 and and CC cord-015306-us58wwmp 2941 19 cardiac cardiac JJ cord-015306-us58wwmp 2941 20 surgery surgery NN cord-015306-us58wwmp 2941 21 complexity complexity NN cord-015306-us58wwmp 2941 22 was be VBD cord-015306-us58wwmp 2941 23 classified classify VBN cord-015306-us58wwmp 2941 24 via via IN cord-015306-us58wwmp 2941 25 RACHS-1 RACHS-1 NNP cord-015306-us58wwmp 2941 26 score score NN cord-015306-us58wwmp 2941 27 . . . cord-015306-us58wwmp 2942 1 Results result NNS cord-015306-us58wwmp 2942 2 : : : cord-015306-us58wwmp 2943 1 Of of IN cord-015306-us58wwmp 2943 2 the the DT cord-015306-us58wwmp 2943 3 20 20 CD cord-015306-us58wwmp 2943 4 enrolled enrol VBN cord-015306-us58wwmp 2943 5 patients patient NNS cord-015306-us58wwmp 2943 6 , , , cord-015306-us58wwmp 2943 7 13 13 CD cord-015306-us58wwmp 2943 8 developed develop VBD cord-015306-us58wwmp 2943 9 at at IN cord-015306-us58wwmp 2943 10 least least JJS cord-015306-us58wwmp 2943 11 Stage stage NN cord-015306-us58wwmp 2943 12 1 1 CD cord-015306-us58wwmp 2943 13 AKI AKI NNP cord-015306-us58wwmp 2943 14 . . . cord-015306-us58wwmp 2944 1 Gender gender NN cord-015306-us58wwmp 2944 2 , , , cord-015306-us58wwmp 2944 3 weight weight NN cord-015306-us58wwmp 2944 4 SDS SDS NNP cord-015306-us58wwmp 2944 5 , , , cord-015306-us58wwmp 2944 6 height height NN cord-015306-us58wwmp 2944 7 SDS SDS NNP cord-015306-us58wwmp 2944 8 , , , cord-015306-us58wwmp 2944 9 baseline baseline JJ cord-015306-us58wwmp 2944 10 eGFR egfr NN cord-015306-us58wwmp 2944 11 , , , cord-015306-us58wwmp 2944 12 cardiac cardiac JJ cord-015306-us58wwmp 2944 13 surgery surgery NN cord-015306-us58wwmp 2944 14 complexity complexity NN cord-015306-us58wwmp 2944 15 , , , cord-015306-us58wwmp 2944 16 and and CC cord-015306-us58wwmp 2944 17 CPB CPB NNP cord-015306-us58wwmp 2944 18 duration duration NN cord-015306-us58wwmp 2944 19 did do VBD cord-015306-us58wwmp 2944 20 not not RB cord-015306-us58wwmp 2944 21 differ differ VB cord-015306-us58wwmp 2944 22 between between IN cord-015306-us58wwmp 2944 23 the the DT cord-015306-us58wwmp 2944 24 AKI AKI NNP cord-015306-us58wwmp 2944 25 group group NN cord-015306-us58wwmp 2944 26 and and CC cord-015306-us58wwmp 2944 27 the the DT cord-015306-us58wwmp 2944 28 non non JJ cord-015306-us58wwmp 2944 29 - - JJ cord-015306-us58wwmp 2944 30 AKI aki JJ cord-015306-us58wwmp 2944 31 group group NN cord-015306-us58wwmp 2944 32 . . . cord-015306-us58wwmp 2945 1 Patients patient NNS cord-015306-us58wwmp 2945 2 who who WP cord-015306-us58wwmp 2945 3 developed develop VBD cord-015306-us58wwmp 2945 4 postoperative postoperative JJ cord-015306-us58wwmp 2945 5 AKI AKI NNP cord-015306-us58wwmp 2945 6 were be VBD cord-015306-us58wwmp 2945 7 younger young JJR cord-015306-us58wwmp 2945 8 than than IN cord-015306-us58wwmp 2945 9 those those DT cord-015306-us58wwmp 2945 10 who who WP cord-015306-us58wwmp 2945 11 did do VBD cord-015306-us58wwmp 2945 12 not not RB cord-015306-us58wwmp 2945 13 . . . cord-015306-us58wwmp 2946 1 Preoperative Preoperative NNP cord-015306-us58wwmp 2946 2 FGF23 fgf23 NN cord-015306-us58wwmp 2946 3 levels level NNS cord-015306-us58wwmp 2946 4 were be VBD cord-015306-us58wwmp 2946 5 inversely inversely RB cord-015306-us58wwmp 2946 6 related relate VBN cord-015306-us58wwmp 2946 7 to to IN cord-015306-us58wwmp 2946 8 age age NN cord-015306-us58wwmp 2947 1 ( ( -LRB- cord-015306-us58wwmp 2947 2 r r NN cord-015306-us58wwmp 2947 3 = = SYM cord-015306-us58wwmp 2947 4 -0.67 -0.67 CD cord-015306-us58wwmp 2947 5 , , , cord-015306-us58wwmp 2947 6 p p NN cord-015306-us58wwmp 2947 7 = = SYM cord-015306-us58wwmp 2947 8 0.001 0.001 CD cord-015306-us58wwmp 2947 9 ) ) -RRB- cord-015306-us58wwmp 2947 10 . . . cord-015306-us58wwmp 2948 1 Pre pre JJ cord-015306-us58wwmp 2948 2 - - JJ cord-015306-us58wwmp 2948 3 operative operative JJ cord-015306-us58wwmp 2948 4 FGF23 fgf23 NN cord-015306-us58wwmp 2948 5 levels level NNS cord-015306-us58wwmp 2948 6 were be VBD cord-015306-us58wwmp 2948 7 significantly significantly RB cord-015306-us58wwmp 2948 8 higher high JJR cord-015306-us58wwmp 2948 9 in in IN cord-015306-us58wwmp 2948 10 patients patient NNS cord-015306-us58wwmp 2948 11 who who WP cord-015306-us58wwmp 2948 12 developed develop VBD cord-015306-us58wwmp 2948 13 AKI AKI NNP cord-015306-us58wwmp 2948 14 than than IN cord-015306-us58wwmp 2948 15 in in IN cord-015306-us58wwmp 2948 16 those those DT cord-015306-us58wwmp 2948 17 who who WP cord-015306-us58wwmp 2948 18 did do VBD cord-015306-us58wwmp 2948 19 not not RB cord-015306-us58wwmp 2948 20 ; ; : cord-015306-us58wwmp 2948 21 this this DT cord-015306-us58wwmp 2948 22 remained remain VBD cord-015306-us58wwmp 2948 23 significant significant JJ cord-015306-us58wwmp 2948 24 upon upon IN cord-015306-us58wwmp 2948 25 correcting correct VBG cord-015306-us58wwmp 2948 26 for for IN cord-015306-us58wwmp 2948 27 age age NN cord-015306-us58wwmp 2948 28 . . . cord-015306-us58wwmp 2949 1 Post post VB cord-015306-us58wwmp 2949 2 - - JJ cord-015306-us58wwmp 2949 3 operatively operatively RB cord-015306-us58wwmp 2949 4 , , , cord-015306-us58wwmp 2949 5 FGF23 fgf23 NN cord-015306-us58wwmp 2949 6 levels level NNS cord-015306-us58wwmp 2949 7 increased increase VBD cord-015306-us58wwmp 2949 8 in in IN cord-015306-us58wwmp 2949 9 all all DT cord-015306-us58wwmp 2949 10 patients patient NNS cord-015306-us58wwmp 2949 11 . . . cord-015306-us58wwmp 2950 1 Conclusion conclusion NN cord-015306-us58wwmp 2950 2 : : : cord-015306-us58wwmp 2951 1 Pre pre JJ cord-015306-us58wwmp 2951 2 - - JJ cord-015306-us58wwmp 2951 3 operative operative JJ cord-015306-us58wwmp 2951 4 FGF23 FGF23 NNP cord-015306-us58wwmp 2951 5 levels level NNS cord-015306-us58wwmp 2951 6 predict predict VBP cord-015306-us58wwmp 2951 7 the the DT cord-015306-us58wwmp 2951 8 development development NN cord-015306-us58wwmp 2951 9 of of IN cord-015306-us58wwmp 2951 10 post post JJ cord-015306-us58wwmp 2951 11 - - JJ cord-015306-us58wwmp 2951 12 operative operative JJ cord-015306-us58wwmp 2951 13 CPB CPB NNP cord-015306-us58wwmp 2951 14 - - HYPH cord-015306-us58wwmp 2951 15 associated associate VBN cord-015306-us58wwmp 2951 16 AKI AKI NNP cord-015306-us58wwmp 2951 17 . . . cord-015306-us58wwmp 2952 1 FGF23 fgf23 NN cord-015306-us58wwmp 2952 2 levels level NNS cord-015306-us58wwmp 2952 3 increase increase VBP cord-015306-us58wwmp 2952 4 in in IN cord-015306-us58wwmp 2952 5 non non JJ cord-015306-us58wwmp 2952 6 - - JJ cord-015306-us58wwmp 2952 7 CKD ckd JJ cord-015306-us58wwmp 2952 8 patients patient NNS cord-015306-us58wwmp 2952 9 undergoing undergo VBG cord-015306-us58wwmp 2952 10 CPB CPB NNP cord-015306-us58wwmp 2952 11 , , , cord-015306-us58wwmp 2952 12 even even RB cord-015306-us58wwmp 2952 13 in in IN cord-015306-us58wwmp 2952 14 patients patient NNS cord-015306-us58wwmp 2952 15 without without IN cord-015306-us58wwmp 2952 16 significant significant JJ cord-015306-us58wwmp 2952 17 changes change NNS cord-015306-us58wwmp 2952 18 in in IN cord-015306-us58wwmp 2952 19 serum serum NN cord-015306-us58wwmp 2952 20 creatinine creatinine NN cord-015306-us58wwmp 2952 21 , , , cord-015306-us58wwmp 2952 22 suggesting suggest VBG cord-015306-us58wwmp 2952 23 that that IN cord-015306-us58wwmp 2952 24 FGF23 FGF23 NNP cord-015306-us58wwmp 2952 25 may may MD cord-015306-us58wwmp 2952 26 be be VB cord-015306-us58wwmp 2952 27 a a DT cord-015306-us58wwmp 2952 28 more more RBR cord-015306-us58wwmp 2952 29 sensitive sensitive JJ cord-015306-us58wwmp 2952 30 marker marker NN cord-015306-us58wwmp 2952 31 of of IN cord-015306-us58wwmp 2952 32 AKI AKI NNP cord-015306-us58wwmp 2952 33 than than IN cord-015306-us58wwmp 2952 34 serum serum NN cord-015306-us58wwmp 2952 35 creatinine creatinine NN cord-015306-us58wwmp 2952 36 . . . cord-015306-us58wwmp 2953 1 Non non JJ cord-015306-us58wwmp 2953 2 - - JJ cord-015306-us58wwmp 2953 3 AKI AKI NNP cord-015306-us58wwmp 2953 4 Pateints Pateints NNP cord-015306-us58wwmp 2953 5 p p NNP cord-015306-us58wwmp 2953 6 value value NN cord-015306-us58wwmp 2953 7 Objective objective NN cord-015306-us58wwmp 2953 8 : : : cord-015306-us58wwmp 2953 9 Improved improve VBN cord-015306-us58wwmp 2953 10 perinatal perinatal JJ cord-015306-us58wwmp 2953 11 care care NN cord-015306-us58wwmp 2953 12 increased increase VBD cord-015306-us58wwmp 2953 13 not not RB cord-015306-us58wwmp 2953 14 only only RB cord-015306-us58wwmp 2953 15 the the DT cord-015306-us58wwmp 2953 16 survival survival NN cord-015306-us58wwmp 2953 17 rate rate NN cord-015306-us58wwmp 2953 18 but but CC cord-015306-us58wwmp 2953 19 also also RB cord-015306-us58wwmp 2953 20 the the DT cord-015306-us58wwmp 2953 21 frequency frequency NN cord-015306-us58wwmp 2953 22 of of IN cord-015306-us58wwmp 2953 23 acute acute JJ cord-015306-us58wwmp 2953 24 kidney kidney NN cord-015306-us58wwmp 2953 25 injury injury NN cord-015306-us58wwmp 2953 26 ( ( -LRB- cord-015306-us58wwmp 2953 27 AKI AKI NNP cord-015306-us58wwmp 2953 28 ) ) -RRB- cord-015306-us58wwmp 2953 29 in in IN cord-015306-us58wwmp 2953 30 newborns newborn NNS cord-015306-us58wwmp 2953 31 . . . cord-015306-us58wwmp 2954 1 We -PRON- PRP cord-015306-us58wwmp 2954 2 aimed aim VBD cord-015306-us58wwmp 2954 3 to to TO cord-015306-us58wwmp 2954 4 determine determine VB cord-015306-us58wwmp 2954 5 the the DT cord-015306-us58wwmp 2954 6 frequency frequency NN cord-015306-us58wwmp 2954 7 , , , cord-015306-us58wwmp 2954 8 etiology etiology NN cord-015306-us58wwmp 2954 9 , , , cord-015306-us58wwmp 2954 10 clinical clinical JJ cord-015306-us58wwmp 2954 11 course course NN cord-015306-us58wwmp 2954 12 and and CC cord-015306-us58wwmp 2954 13 mortality mortality NN cord-015306-us58wwmp 2954 14 of of IN cord-015306-us58wwmp 2954 15 AKI AKI NNP cord-015306-us58wwmp 2954 16 in in IN cord-015306-us58wwmp 2954 17 a a DT cord-015306-us58wwmp 2954 18 third third JJ cord-015306-us58wwmp 2954 19 level level NN cord-015306-us58wwmp 2954 20 neonatal neonatal JJ cord-015306-us58wwmp 2954 21 intensive intensive JJ cord-015306-us58wwmp 2954 22 care care NN cord-015306-us58wwmp 2954 23 unit unit NN cord-015306-us58wwmp 2954 24 ( ( -LRB- cord-015306-us58wwmp 2954 25 NICU NICU NNP cord-015306-us58wwmp 2954 26 ) ) -RRB- cord-015306-us58wwmp 2954 27 . . . cord-015306-us58wwmp 2955 1 Methods method NNS cord-015306-us58wwmp 2955 2 : : : cord-015306-us58wwmp 2956 1 Medical medical JJ cord-015306-us58wwmp 2956 2 records record NNS cord-015306-us58wwmp 2956 3 of of IN cord-015306-us58wwmp 2956 4 all all DT cord-015306-us58wwmp 2956 5 patients patient NNS cord-015306-us58wwmp 2956 6 admitted admit VBN cord-015306-us58wwmp 2956 7 to to IN cord-015306-us58wwmp 2956 8 a a DT cord-015306-us58wwmp 2956 9 NICU NICU NNP cord-015306-us58wwmp 2956 10 in in IN cord-015306-us58wwmp 2956 11 western western JJ cord-015306-us58wwmp 2956 12 Turkey Turkey NNP cord-015306-us58wwmp 2956 13 during during IN cord-015306-us58wwmp 2956 14 2007 2007 CD cord-015306-us58wwmp 2956 15 - - SYM cord-015306-us58wwmp 2956 16 2011 2011 CD cord-015306-us58wwmp 2956 17 were be VBD cord-015306-us58wwmp 2956 18 evaluated evaluate VBN cord-015306-us58wwmp 2956 19 and and CC cord-015306-us58wwmp 2956 20 those those DT cord-015306-us58wwmp 2956 21 having have VBG cord-015306-us58wwmp 2956 22 AKI AKI NNP cord-015306-us58wwmp 2956 23 within within IN cord-015306-us58wwmp 2956 24 0 0 CD cord-015306-us58wwmp 2956 25 - - SYM cord-015306-us58wwmp 2956 26 30 30 CD cord-015306-us58wwmp 2956 27 days day NNS cord-015306-us58wwmp 2956 28 of of IN cord-015306-us58wwmp 2956 29 life life NN cord-015306-us58wwmp 2956 30 were be VBD cord-015306-us58wwmp 2956 31 determined determine VBN cord-015306-us58wwmp 2956 32 . . . cord-015306-us58wwmp 2957 1 Birth birth NN cord-015306-us58wwmp 2957 2 weight weight NN cord-015306-us58wwmp 2957 3 , , , cord-015306-us58wwmp 2957 4 gestational gestational JJ cord-015306-us58wwmp 2957 5 age age NN cord-015306-us58wwmp 2957 6 , , , cord-015306-us58wwmp 2957 7 mode mode NN cord-015306-us58wwmp 2957 8 of of IN cord-015306-us58wwmp 2957 9 delivery delivery NN cord-015306-us58wwmp 2957 10 , , , cord-015306-us58wwmp 2957 11 gender gender NN cord-015306-us58wwmp 2957 12 , , , cord-015306-us58wwmp 2957 13 maternal maternal JJ cord-015306-us58wwmp 2957 14 morbidity morbidity NN cord-015306-us58wwmp 2957 15 , , , cord-015306-us58wwmp 2957 16 hospitalization hospitalization NN cord-015306-us58wwmp 2957 17 period period NN cord-015306-us58wwmp 2957 18 , , , cord-015306-us58wwmp 2957 19 accompanying accompany VBG cord-015306-us58wwmp 2957 20 morbidities morbidity NNS cord-015306-us58wwmp 2957 21 and and CC cord-015306-us58wwmp 2957 22 mortality mortality NN cord-015306-us58wwmp 2957 23 of of IN cord-015306-us58wwmp 2957 24 all all DT cord-015306-us58wwmp 2957 25 patients patient NNS cord-015306-us58wwmp 2957 26 ; ; : cord-015306-us58wwmp 2957 27 and and CC cord-015306-us58wwmp 2957 28 primary primary JJ cord-015306-us58wwmp 2957 29 disease disease NN cord-015306-us58wwmp 2957 30 causing cause VBG cord-015306-us58wwmp 2957 31 AKI AKI NNP cord-015306-us58wwmp 2957 32 , , , cord-015306-us58wwmp 2957 33 highest high JJS cord-015306-us58wwmp 2957 34 serum serum NN cord-015306-us58wwmp 2957 35 creatinine creatinine NN cord-015306-us58wwmp 2957 36 and and CC cord-015306-us58wwmp 2957 37 prognosis prognosis NN cord-015306-us58wwmp 2957 38 of of IN cord-015306-us58wwmp 2957 39 patients patient NNS cord-015306-us58wwmp 2957 40 with with IN cord-015306-us58wwmp 2957 41 AKI AKI NNP cord-015306-us58wwmp 2957 42 were be VBD cord-015306-us58wwmp 2957 43 recorded record VBN cord-015306-us58wwmp 2957 44 . . . cord-015306-us58wwmp 2958 1 Results result NNS cord-015306-us58wwmp 2958 2 : : : cord-015306-us58wwmp 2959 1 There there EX cord-015306-us58wwmp 2959 2 were be VBD cord-015306-us58wwmp 2959 3 677 677 CD cord-015306-us58wwmp 2959 4 patients patient NNS cord-015306-us58wwmp 2959 5 ( ( -LRB- cord-015306-us58wwmp 2959 6 M M NNP cord-015306-us58wwmp 2959 7 / / SYM cord-015306-us58wwmp 2959 8 F:392/285 F:392/285 NNP cord-015306-us58wwmp 2959 9 ) ) -RRB- cord-015306-us58wwmp 2959 10 and and CC cord-015306-us58wwmp 2959 11 94 94 CD cord-015306-us58wwmp 2959 12 ( ( -LRB- cord-015306-us58wwmp 2959 13 13,9 13,9 CD cord-015306-us58wwmp 2959 14 % % NN cord-015306-us58wwmp 2959 15 ) ) -RRB- cord-015306-us58wwmp 2959 16 had have VBD cord-015306-us58wwmp 2959 17 AKI AKI NNP cord-015306-us58wwmp 2959 18 of of IN cord-015306-us58wwmp 2959 19 which which WDT cord-015306-us58wwmp 2959 20 80 80 CD cord-015306-us58wwmp 2959 21 % % NN cord-015306-us58wwmp 2959 22 developed develop VBN cord-015306-us58wwmp 2959 23 during during IN cord-015306-us58wwmp 2959 24 0 0 CD cord-015306-us58wwmp 2959 25 - - SYM cord-015306-us58wwmp 2959 26 7 7 CD cord-015306-us58wwmp 2959 27 days day NNS cord-015306-us58wwmp 2959 28 of of IN cord-015306-us58wwmp 2959 29 life life NN cord-015306-us58wwmp 2959 30 mostly mostly RB cord-015306-us58wwmp 2959 31 due due JJ cord-015306-us58wwmp 2959 32 to to IN cord-015306-us58wwmp 2959 33 birth birth NN cord-015306-us58wwmp 2959 34 asphyxia asphyxia NN cord-015306-us58wwmp 2959 35 , , , cord-015306-us58wwmp 2959 36 hypovolemia hypovolemia NN cord-015306-us58wwmp 2959 37 , , , cord-015306-us58wwmp 2959 38 cardiac cardiac JJ cord-015306-us58wwmp 2959 39 disease disease NN cord-015306-us58wwmp 2959 40 , , , cord-015306-us58wwmp 2959 41 sepsis sepsis NN cord-015306-us58wwmp 2959 42 and and CC cord-015306-us58wwmp 2959 43 urinary urinary JJ cord-015306-us58wwmp 2959 44 system system NN cord-015306-us58wwmp 2959 45 anomalies anomaly NNS cord-015306-us58wwmp 2959 46 . . . cord-015306-us58wwmp 2960 1 AKI AKI NNP cord-015306-us58wwmp 2960 2 incidence incidence NN cord-015306-us58wwmp 2960 3 and and CC cord-015306-us58wwmp 2960 4 total total JJ cord-015306-us58wwmp 2960 5 mortality mortality NN cord-015306-us58wwmp 2960 6 rate rate NN cord-015306-us58wwmp 2960 7 were be VBD cord-015306-us58wwmp 2960 8 higher high JJR cord-015306-us58wwmp 2960 9 in in IN cord-015306-us58wwmp 2960 10 patients patient NNS cord-015306-us58wwmp 2960 11 with with IN cord-015306-us58wwmp 2960 12 birth birth NN cord-015306-us58wwmp 2960 13 weight weight NN cord-015306-us58wwmp 2960 14 < < XX cord-015306-us58wwmp 2960 15 1000 1000 CD cord-015306-us58wwmp 2960 16 g g NN cord-015306-us58wwmp 2960 17 and and CC cord-015306-us58wwmp 2960 18 with with IN cord-015306-us58wwmp 2960 19 gestational gestational JJ cord-015306-us58wwmp 2960 20 age age NN cord-015306-us58wwmp 2960 21 < < XX cord-015306-us58wwmp 2960 22 28 28 CD cord-015306-us58wwmp 2960 23 week week NN cord-015306-us58wwmp 2960 24 . . . cord-015306-us58wwmp 2961 1 However however RB cord-015306-us58wwmp 2961 2 , , , cord-015306-us58wwmp 2961 3 mortality mortality NN cord-015306-us58wwmp 2961 4 in in IN cord-015306-us58wwmp 2961 5 patients patient NNS cord-015306-us58wwmp 2961 6 with with IN cord-015306-us58wwmp 2961 7 AKI AKI NNP cord-015306-us58wwmp 2961 8 was be VBD cord-015306-us58wwmp 2961 9 increased increase VBN cord-015306-us58wwmp 2961 10 independent independent JJ cord-015306-us58wwmp 2961 11 on on IN cord-015306-us58wwmp 2961 12 birth birth NN cord-015306-us58wwmp 2961 13 weight weight NN cord-015306-us58wwmp 2961 14 ( ( -LRB- cord-015306-us58wwmp 2961 15 42,1 42,1 CD cord-015306-us58wwmp 2961 16 % % NN cord-015306-us58wwmp 2961 17 in in IN cord-015306-us58wwmp 2961 18 < < NNP cord-015306-us58wwmp 2961 19 1000 1000 CD cord-015306-us58wwmp 2961 20 g g NN cord-015306-us58wwmp 2961 21 vs vs IN cord-015306-us58wwmp 2961 22 32,1 32,1 CD cord-015306-us58wwmp 2961 23 % % NN cord-015306-us58wwmp 2961 24 in in IN cord-015306-us58wwmp 2961 25 > > NN cord-015306-us58wwmp 2961 26 1000 1000 CD cord-015306-us58wwmp 2961 27 g g NN cord-015306-us58wwmp 2961 28 ; ; : cord-015306-us58wwmp 2961 29 p=0,324 p=0,324 NNP cord-015306-us58wwmp 2961 30 ) ) -RRB- cord-015306-us58wwmp 2961 31 and and CC cord-015306-us58wwmp 2961 32 gestational gestational JJ cord-015306-us58wwmp 2961 33 age age NN cord-015306-us58wwmp 2962 1 ( ( -LRB- cord-015306-us58wwmp 2962 2 44,1 44,1 CD cord-015306-us58wwmp 2962 3 % % NN cord-015306-us58wwmp 2962 4 in in IN cord-015306-us58wwmp 2962 5 < < NNP cord-015306-us58wwmp 2962 6 28 28 CD cord-015306-us58wwmp 2962 7 week week NN cord-015306-us58wwmp 2962 8 vs vs IN cord-015306-us58wwmp 2962 9 31,7 31,7 CD cord-015306-us58wwmp 2962 10 % % NN cord-015306-us58wwmp 2962 11 in in IN cord-015306-us58wwmp 2962 12 > > NNP cord-015306-us58wwmp 2962 13 28 28 CD cord-015306-us58wwmp 2962 14 week week NN cord-015306-us58wwmp 2962 15 ; ; : cord-015306-us58wwmp 2963 1 p=0,227 p=0,227 UH cord-015306-us58wwmp 2963 2 ) ) -RRB- cord-015306-us58wwmp 2963 3 . . . cord-015306-us58wwmp 2964 1 Mortality mortality NN cord-015306-us58wwmp 2964 2 tended tend VBD cord-015306-us58wwmp 2964 3 to to TO cord-015306-us58wwmp 2964 4 increase increase VB cord-015306-us58wwmp 2964 5 in in IN cord-015306-us58wwmp 2964 6 the the DT cord-015306-us58wwmp 2964 7 presence presence NN cord-015306-us58wwmp 2964 8 of of IN cord-015306-us58wwmp 2964 9 AKI AKI NNP cord-015306-us58wwmp 2964 10 independent independent JJ cord-015306-us58wwmp 2964 11 on on IN cord-015306-us58wwmp 2964 12 the the DT cord-015306-us58wwmp 2964 13 underlying underlying JJ cord-015306-us58wwmp 2964 14 cause cause NN cord-015306-us58wwmp 2964 15 , , , cord-015306-us58wwmp 2964 16 but but CC cord-015306-us58wwmp 2964 17 this this DT cord-015306-us58wwmp 2964 18 was be VBD cord-015306-us58wwmp 2964 19 significant significant JJ cord-015306-us58wwmp 2964 20 only only RB cord-015306-us58wwmp 2964 21 for for IN cord-015306-us58wwmp 2964 22 sepsis sepsis NN cord-015306-us58wwmp 2964 23 ( ( -LRB- cord-015306-us58wwmp 2964 24 33 33 CD cord-015306-us58wwmp 2964 25 , , , cord-015306-us58wwmp 2964 26 3 3 CD cord-015306-us58wwmp 2964 27 % % NN cord-015306-us58wwmp 2964 28 vs vs IN cord-015306-us58wwmp 2964 29 5 5 CD cord-015306-us58wwmp 2964 30 , , , cord-015306-us58wwmp 2964 31 9 9 CD cord-015306-us58wwmp 2964 32 % % NN cord-015306-us58wwmp 2964 33 , , , cord-015306-us58wwmp 2964 34 p<0 p<0 NNP cord-015306-us58wwmp 2964 35 , , , cord-015306-us58wwmp 2964 36 001 001 CD cord-015306-us58wwmp 2964 37 ; ; : cord-015306-us58wwmp 2964 38 OR or CC cord-015306-us58wwmp 2964 39 7 7 CD cord-015306-us58wwmp 2964 40 , , , cord-015306-us58wwmp 2964 41 9 9 CD cord-015306-us58wwmp 2964 42 ) ) -RRB- cord-015306-us58wwmp 2964 43 and and CC cord-015306-us58wwmp 2964 44 cardiac cardiac JJ cord-015306-us58wwmp 2964 45 diseases disease NNS cord-015306-us58wwmp 2964 46 ( ( -LRB- cord-015306-us58wwmp 2964 47 50,0 50,0 CD cord-015306-us58wwmp 2964 48 % % NN cord-015306-us58wwmp 2964 49 vs vs IN cord-015306-us58wwmp 2964 50 15,0 15,0 CD cord-015306-us58wwmp 2964 51 % % NN cord-015306-us58wwmp 2964 52 , , , cord-015306-us58wwmp 2964 53 p=0,001 p=0,001 NNP cord-015306-us58wwmp 2964 54 ; ; : cord-015306-us58wwmp 2964 55 OR or CC cord-015306-us58wwmp 2964 56 5 5 CD cord-015306-us58wwmp 2964 57 , , , cord-015306-us58wwmp 2964 58 6 6 CD cord-015306-us58wwmp 2964 59 ) ) -RRB- cord-015306-us58wwmp 2964 60 . . . cord-015306-us58wwmp 2965 1 Hospitalization hospitalization NN cord-015306-us58wwmp 2965 2 period period NN cord-015306-us58wwmp 2965 3 was be VBD cord-015306-us58wwmp 2965 4 increased increase VBN cord-015306-us58wwmp 2965 5 if if IN cord-015306-us58wwmp 2965 6 AKI AKI NNP cord-015306-us58wwmp 2965 7 was be VBD cord-015306-us58wwmp 2965 8 present present JJ cord-015306-us58wwmp 2965 9 ( ( -LRB- cord-015306-us58wwmp 2965 10 39,1 39,1 CD cord-015306-us58wwmp 2965 11 vs vs IN cord-015306-us58wwmp 2965 12 20,5 20,5 CD cord-015306-us58wwmp 2965 13 days day NNS cord-015306-us58wwmp 2965 14 , , , cord-015306-us58wwmp 2965 15 p<0,001 p<0,001 NNP cord-015306-us58wwmp 2965 16 ) ) -RRB- cord-015306-us58wwmp 2965 17 . . . cord-015306-us58wwmp 2966 1 Serum serum NN cord-015306-us58wwmp 2966 2 creatinine creatinine NN cord-015306-us58wwmp 2966 3 in in IN cord-015306-us58wwmp 2966 4 deceased deceased JJ cord-015306-us58wwmp 2966 5 patients patient NNS cord-015306-us58wwmp 2966 6 with with IN cord-015306-us58wwmp 2966 7 AKI AKI NNP cord-015306-us58wwmp 2966 8 was be VBD cord-015306-us58wwmp 2966 9 higher high JJR cord-015306-us58wwmp 2966 10 than than IN cord-015306-us58wwmp 2966 11 those those DT cord-015306-us58wwmp 2966 12 who who WP cord-015306-us58wwmp 2966 13 survived survive VBD cord-015306-us58wwmp 2966 14 ( ( -LRB- cord-015306-us58wwmp 2966 15 2,0 2,0 CD cord-015306-us58wwmp 2966 16 vs vs IN cord-015306-us58wwmp 2966 17 1,6 1,6 CD cord-015306-us58wwmp 2967 1 mg mg NNP cord-015306-us58wwmp 2967 2 / / SYM cord-015306-us58wwmp 2967 3 dL dl NN cord-015306-us58wwmp 2967 4 , , , cord-015306-us58wwmp 2967 5 p<0,05 p<0,05 NNP cord-015306-us58wwmp 2967 6 ) ) -RRB- cord-015306-us58wwmp 2967 7 . . . cord-015306-us58wwmp 2968 1 Chronic chronic JJ cord-015306-us58wwmp 2968 2 kidney kidney NN cord-015306-us58wwmp 2968 3 disease disease NN cord-015306-us58wwmp 2968 4 was be VBD cord-015306-us58wwmp 2968 5 developed develop VBN cord-015306-us58wwmp 2968 6 in in IN cord-015306-us58wwmp 2968 7 6 6 CD cord-015306-us58wwmp 2968 8 ( ( -LRB- cord-015306-us58wwmp 2968 9 10 10 CD cord-015306-us58wwmp 2968 10 % % NN cord-015306-us58wwmp 2968 11 ) ) -RRB- cord-015306-us58wwmp 2968 12 patients patient NNS cord-015306-us58wwmp 2968 13 of of IN cord-015306-us58wwmp 2968 14 whom whom WP cord-015306-us58wwmp 2968 15 3 3 CD cord-015306-us58wwmp 2968 16 had have VBD cord-015306-us58wwmp 2968 17 urinary urinary JJ cord-015306-us58wwmp 2968 18 tract tract JJ cord-015306-us58wwmp 2968 19 anomalies anomaly NNS cord-015306-us58wwmp 2968 20 and and CC cord-015306-us58wwmp 2968 21 3 3 CD cord-015306-us58wwmp 2968 22 had have VBD cord-015306-us58wwmp 2968 23 birth birth NN cord-015306-us58wwmp 2968 24 asphyxia asphyxia NN cord-015306-us58wwmp 2968 25 . . . cord-015306-us58wwmp 2969 1 Conclusion conclusion NN cord-015306-us58wwmp 2969 2 : : : cord-015306-us58wwmp 2969 3 AKI AKI NNP cord-015306-us58wwmp 2969 4 incidence incidence NN cord-015306-us58wwmp 2969 5 in in IN cord-015306-us58wwmp 2969 6 NICU NICU NNP cord-015306-us58wwmp 2969 7 was be VBD cord-015306-us58wwmp 2969 8 14 14 CD cord-015306-us58wwmp 2969 9 % % NN cord-015306-us58wwmp 2969 10 , , , cord-015306-us58wwmp 2969 11 and and CC cord-015306-us58wwmp 2969 12 80 80 CD cord-015306-us58wwmp 2969 13 % % NN cord-015306-us58wwmp 2969 14 of of IN cord-015306-us58wwmp 2969 15 AKI AKI NNP cord-015306-us58wwmp 2969 16 developed develop VBN cord-015306-us58wwmp 2969 17 during during IN cord-015306-us58wwmp 2969 18 the the DT cord-015306-us58wwmp 2969 19 first first JJ cord-015306-us58wwmp 2969 20 week week NN cord-015306-us58wwmp 2969 21 of of IN cord-015306-us58wwmp 2969 22 life life NN cord-015306-us58wwmp 2969 23 . . . cord-015306-us58wwmp 2970 1 AKI AKI NNP cord-015306-us58wwmp 2970 2 is be VBZ cord-015306-us58wwmp 2970 3 associated associate VBN cord-015306-us58wwmp 2970 4 with with IN cord-015306-us58wwmp 2970 5 low low JJ cord-015306-us58wwmp 2970 6 birth birth NN cord-015306-us58wwmp 2970 7 weight weight NN cord-015306-us58wwmp 2970 8 , , , cord-015306-us58wwmp 2970 9 prematurity prematurity NN cord-015306-us58wwmp 2970 10 , , , cord-015306-us58wwmp 2970 11 birth birth NN cord-015306-us58wwmp 2970 12 asphyxia asphyxia NN cord-015306-us58wwmp 2970 13 , , , cord-015306-us58wwmp 2970 14 sepsis sepsis NN cord-015306-us58wwmp 2970 15 , , , cord-015306-us58wwmp 2970 16 hypovolemia hypovolemia NN cord-015306-us58wwmp 2970 17 , , , cord-015306-us58wwmp 2970 18 cardiac cardiac JJ cord-015306-us58wwmp 2970 19 diseases disease NNS cord-015306-us58wwmp 2970 20 and and CC cord-015306-us58wwmp 2970 21 urinary urinary JJ cord-015306-us58wwmp 2970 22 tract tract NN cord-015306-us58wwmp 2970 23 anomalies anomaly NNS cord-015306-us58wwmp 2970 24 . . . cord-015306-us58wwmp 2971 1 Mortality mortality NN cord-015306-us58wwmp 2971 2 in in IN cord-015306-us58wwmp 2971 3 patients patient NNS cord-015306-us58wwmp 2971 4 with with IN cord-015306-us58wwmp 2971 5 AKI AKI NNP cord-015306-us58wwmp 2971 6 is be VBZ cord-015306-us58wwmp 2971 7 increased increase VBN cord-015306-us58wwmp 2971 8 independent independent JJ cord-015306-us58wwmp 2971 9 on on IN cord-015306-us58wwmp 2971 10 the the DT cord-015306-us58wwmp 2971 11 birth birth NN cord-015306-us58wwmp 2971 12 weight weight NN cord-015306-us58wwmp 2971 13 , , , cord-015306-us58wwmp 2971 14 gestational gestational JJ cord-015306-us58wwmp 2971 15 age age NN cord-015306-us58wwmp 2971 16 and and CC cord-015306-us58wwmp 2971 17 underlying underlying JJ cord-015306-us58wwmp 2971 18 etiology etiology NN cord-015306-us58wwmp 2971 19 . . . cord-015306-us58wwmp 2972 1 Objective objective NN cord-015306-us58wwmp 2972 2 : : : cord-015306-us58wwmp 2973 1 Cisplatin cisplatin NN cord-015306-us58wwmp 2973 2 ( ( -LRB- cord-015306-us58wwmp 2973 3 CDDP CDDP NNP cord-015306-us58wwmp 2973 4 ) ) -RRB- cord-015306-us58wwmp 2973 5 is be VBZ cord-015306-us58wwmp 2973 6 one one CD cord-015306-us58wwmp 2973 7 of of IN cord-015306-us58wwmp 2973 8 the the DT cord-015306-us58wwmp 2973 9 antineoplastic antineoplastic JJ cord-015306-us58wwmp 2973 10 agents agent NNS cord-015306-us58wwmp 2973 11 widely widely RB cord-015306-us58wwmp 2973 12 used use VBN cord-015306-us58wwmp 2973 13 for for IN cord-015306-us58wwmp 2973 14 solid solid JJ cord-015306-us58wwmp 2973 15 tumors tumor NNS cord-015306-us58wwmp 2973 16 in in IN cord-015306-us58wwmp 2973 17 adults adult NNS cord-015306-us58wwmp 2973 18 and and CC cord-015306-us58wwmp 2973 19 children child NNS cord-015306-us58wwmp 2973 20 . . . cord-015306-us58wwmp 2974 1 An an DT cord-015306-us58wwmp 2974 2 excessive excessive JJ cord-015306-us58wwmp 2974 3 dose dose NN cord-015306-us58wwmp 2974 4 due due IN cord-015306-us58wwmp 2974 5 to to IN cord-015306-us58wwmp 2974 6 medical medical JJ cord-015306-us58wwmp 2974 7 error error NN cord-015306-us58wwmp 2974 8 causes cause VBZ cord-015306-us58wwmp 2974 9 severe severe JJ cord-015306-us58wwmp 2974 10 nephrotoxicity nephrotoxicity NN cord-015306-us58wwmp 2974 11 , , , cord-015306-us58wwmp 2974 12 ototoxicity ototoxicity NNP cord-015306-us58wwmp 2974 13 and and CC cord-015306-us58wwmp 2974 14 myelosuppression myelosuppression NNP cord-015306-us58wwmp 2974 15 . . . cord-015306-us58wwmp 2975 1 Previous previous JJ cord-015306-us58wwmp 2975 2 reports report NNS cord-015306-us58wwmp 2975 3 described describe VBD cord-015306-us58wwmp 2975 4 the the DT cord-015306-us58wwmp 2975 5 effects effect NNS cord-015306-us58wwmp 2975 6 of of IN cord-015306-us58wwmp 2975 7 plasma plasma NN cord-015306-us58wwmp 2975 8 exchange exchange NN cord-015306-us58wwmp 2975 9 , , , cord-015306-us58wwmp 2975 10 sodium sodium NN cord-015306-us58wwmp 2975 11 thiosulfate thiosulfate NN cord-015306-us58wwmp 2975 12 , , , cord-015306-us58wwmp 2975 13 N n CD cord-015306-us58wwmp 2975 14 - - HYPH cord-015306-us58wwmp 2975 15 acetylcysteine acetylcysteine NN cord-015306-us58wwmp 2975 16 and and CC cord-015306-us58wwmp 2975 17 other other JJ cord-015306-us58wwmp 2975 18 interventions intervention NNS cord-015306-us58wwmp 2975 19 . . . cord-015306-us58wwmp 2976 1 However however RB cord-015306-us58wwmp 2976 2 , , , cord-015306-us58wwmp 2976 3 the the DT cord-015306-us58wwmp 2976 4 strategy strategy NN cord-015306-us58wwmp 2976 5 for for IN cord-015306-us58wwmp 2976 6 over over IN cord-015306-us58wwmp 2976 7 - - HYPH cord-015306-us58wwmp 2976 8 dose dose NN cord-015306-us58wwmp 2976 9 patients patient NNS cord-015306-us58wwmp 2976 10 , , , cord-015306-us58wwmp 2976 11 as as IN cord-015306-us58wwmp 2976 12 regards regard VBZ cord-015306-us58wwmp 2976 13 the the DT cord-015306-us58wwmp 2976 14 selection selection NN cord-015306-us58wwmp 2976 15 or or CC cord-015306-us58wwmp 2976 16 intensity intensity NN cord-015306-us58wwmp 2976 17 of of IN cord-015306-us58wwmp 2976 18 therapies therapy NNS cord-015306-us58wwmp 2976 19 and and CC cord-015306-us58wwmp 2976 20 the the DT cord-015306-us58wwmp 2976 21 target target NN cord-015306-us58wwmp 2976 22 of of IN cord-015306-us58wwmp 2976 23 cisplatin cisplatin NN cord-015306-us58wwmp 2976 24 removal removal NN cord-015306-us58wwmp 2976 25 , , , cord-015306-us58wwmp 2976 26 remains remain VBZ cord-015306-us58wwmp 2976 27 uncertain uncertain JJ cord-015306-us58wwmp 2976 28 in in IN cord-015306-us58wwmp 2976 29 children child NNS cord-015306-us58wwmp 2976 30 . . . cord-015306-us58wwmp 2977 1 A a DT cord-015306-us58wwmp 2977 2 12 12 CD cord-015306-us58wwmp 2977 3 year year NN cord-015306-us58wwmp 2977 4 - - HYPH cord-015306-us58wwmp 2977 5 old old JJ cord-015306-us58wwmp 2977 6 girl girl NN cord-015306-us58wwmp 2977 7 was be VBD cord-015306-us58wwmp 2977 8 admitted admit VBN cord-015306-us58wwmp 2977 9 for for IN cord-015306-us58wwmp 2977 10 headache headache NN cord-015306-us58wwmp 2977 11 and and CC cord-015306-us58wwmp 2977 12 vomiting vomiting NN cord-015306-us58wwmp 2977 13 . . . cord-015306-us58wwmp 2978 1 She -PRON- PRP cord-015306-us58wwmp 2978 2 was be VBD cord-015306-us58wwmp 2978 3 found find VBN cord-015306-us58wwmp 2978 4 to to TO cord-015306-us58wwmp 2978 5 have have VB cord-015306-us58wwmp 2978 6 a a DT cord-015306-us58wwmp 2978 7 right right JJ cord-015306-us58wwmp 2978 8 cerebellar cerebellar JJ cord-015306-us58wwmp 2978 9 tumor tumor NN cord-015306-us58wwmp 2978 10 and and CC cord-015306-us58wwmp 2978 11 underwent undergo VBD cord-015306-us58wwmp 2978 12 total total JJ cord-015306-us58wwmp 2978 13 extirpation extirpation NN cord-015306-us58wwmp 2978 14 of of IN cord-015306-us58wwmp 2978 15 this this DT cord-015306-us58wwmp 2978 16 medulloblastoma medulloblastoma NNP cord-015306-us58wwmp 2978 17 . . . cord-015306-us58wwmp 2979 1 Next next RB cord-015306-us58wwmp 2979 2 , , , cord-015306-us58wwmp 2979 3 we -PRON- PRP cord-015306-us58wwmp 2979 4 administered administer VBD cord-015306-us58wwmp 2979 5 chemotherapy chemotherapy NN cord-015306-us58wwmp 2979 6 mainly mainly RB cord-015306-us58wwmp 2979 7 using use VBG cord-015306-us58wwmp 2979 8 CDDP CDDP NNP cord-015306-us58wwmp 2979 9 . . . cord-015306-us58wwmp 2980 1 However however RB cord-015306-us58wwmp 2980 2 , , , cord-015306-us58wwmp 2980 3 she -PRON- PRP cord-015306-us58wwmp 2980 4 developed develop VBD cord-015306-us58wwmp 2980 5 renal renal JJ cord-015306-us58wwmp 2980 6 insufficiency insufficiency NN cord-015306-us58wwmp 2980 7 and and CC cord-015306-us58wwmp 2980 8 hearing hear VBG cord-015306-us58wwmp 2980 9 loss loss NN cord-015306-us58wwmp 2980 10 on on IN cord-015306-us58wwmp 2980 11 the the DT cord-015306-us58wwmp 2980 12 fourth fourth JJ cord-015306-us58wwmp 2980 13 day day NN cord-015306-us58wwmp 2980 14 . . . cord-015306-us58wwmp 2981 1 We -PRON- PRP cord-015306-us58wwmp 2981 2 then then RB cord-015306-us58wwmp 2981 3 realized realize VBD cord-015306-us58wwmp 2981 4 that that IN cord-015306-us58wwmp 2981 5 we -PRON- PRP cord-015306-us58wwmp 2981 6 had have VBD cord-015306-us58wwmp 2981 7 been be VBN cord-015306-us58wwmp 2981 8 administering administer VBG cord-015306-us58wwmp 2981 9 CDDP CDDP NNP cord-015306-us58wwmp 2982 1 90 90 CD cord-015306-us58wwmp 2982 2 mg mg NNP cord-015306-us58wwmp 2982 3 / / SYM cord-015306-us58wwmp 2982 4 m m NN cord-015306-us58wwmp 2982 5 2 2 CD cord-015306-us58wwmp 2982 6 for for IN cord-015306-us58wwmp 2982 7 4 4 CD cord-015306-us58wwmp 2982 8 days day NNS cord-015306-us58wwmp 2982 9 , , , cord-015306-us58wwmp 2982 10 instead instead RB cord-015306-us58wwmp 2982 11 of of IN cord-015306-us58wwmp 2982 12 the the DT cord-015306-us58wwmp 2982 13 intended intended JJ cord-015306-us58wwmp 2982 14 1 1 CD cord-015306-us58wwmp 2982 15 day day NN cord-015306-us58wwmp 2982 16 . . . cord-015306-us58wwmp 2983 1 We -PRON- PRP cord-015306-us58wwmp 2983 2 promptly promptly RB cord-015306-us58wwmp 2983 3 discontinued discontinue VBD cord-015306-us58wwmp 2983 4 the the DT cord-015306-us58wwmp 2983 5 CDDP CDDP NNP cord-015306-us58wwmp 2983 6 and and CC cord-015306-us58wwmp 2983 7 began begin VBD cord-015306-us58wwmp 2983 8 plasma plasma NN cord-015306-us58wwmp 2983 9 exchange exchange NN cord-015306-us58wwmp 2983 10 and and CC cord-015306-us58wwmp 2983 11 sodium sodium NN cord-015306-us58wwmp 2983 12 thiosulfate thiosulfate NNP cord-015306-us58wwmp 2983 13 administration administration NN cord-015306-us58wwmp 2983 14 . . . cord-015306-us58wwmp 2984 1 Nonoligiric nonoligiric JJ cord-015306-us58wwmp 2984 2 renal renal JJ cord-015306-us58wwmp 2984 3 failure failure NN cord-015306-us58wwmp 2984 4 was be VBD cord-015306-us58wwmp 2984 5 confirmed confirm VBN cord-015306-us58wwmp 2984 6 by by IN cord-015306-us58wwmp 2984 7 a a DT cord-015306-us58wwmp 2984 8 urea urea NN cord-015306-us58wwmp 2984 9 nitrogen nitrogen NN cord-015306-us58wwmp 2984 10 value value NN cord-015306-us58wwmp 2984 11 of of IN cord-015306-us58wwmp 2984 12 63.6 63.6 CD cord-015306-us58wwmp 2984 13 mg mg NNP cord-015306-us58wwmp 2984 14 / / SYM cord-015306-us58wwmp 2984 15 dL dl NN cord-015306-us58wwmp 2984 16 and and CC cord-015306-us58wwmp 2984 17 creatinine creatinine JJ cord-015306-us58wwmp 2984 18 level level NN cord-015306-us58wwmp 2984 19 of of IN cord-015306-us58wwmp 2984 20 4.4 4.4 CD cord-015306-us58wwmp 2984 21 mg mg NN cord-015306-us58wwmp 2984 22 / / SYM cord-015306-us58wwmp 2984 23 dL. dL. NNS cord-015306-us58wwmp 2985 1 With with IN cord-015306-us58wwmp 2985 2 4 4 CD cord-015306-us58wwmp 2985 3 cycles cycle NNS cord-015306-us58wwmp 2985 4 of of IN cord-015306-us58wwmp 2985 5 plasma plasma NN cord-015306-us58wwmp 2985 6 exchange exchange NN cord-015306-us58wwmp 2985 7 and and CC cord-015306-us58wwmp 2985 8 2 2 CD cord-015306-us58wwmp 2985 9 weeks week NNS cord-015306-us58wwmp 2985 10 of of IN cord-015306-us58wwmp 2985 11 sodium sodium NN cord-015306-us58wwmp 2985 12 thiosulfate thiosulfate NN cord-015306-us58wwmp 2985 13 , , , cord-015306-us58wwmp 2985 14 renal renal JJ cord-015306-us58wwmp 2985 15 function function NN cord-015306-us58wwmp 2985 16 improved improve VBD cord-015306-us58wwmp 2985 17 and and CC cord-015306-us58wwmp 2985 18 the the DT cord-015306-us58wwmp 2985 19 CDDP CDDP NNP cord-015306-us58wwmp 2985 20 concentration concentration NN cord-015306-us58wwmp 2985 21 decreased decrease VBD cord-015306-us58wwmp 2985 22 from from IN cord-015306-us58wwmp 2985 23 6.04 6.04 CD cord-015306-us58wwmp 2985 24 to to IN cord-015306-us58wwmp 2985 25 0.99 0.99 CD cord-015306-us58wwmp 2985 26 mg mg NNP cord-015306-us58wwmp 2985 27 / / SYM cord-015306-us58wwmp 2985 28 mL. mL. NNP cord-015306-us58wwmp 2986 1 After after IN cord-015306-us58wwmp 2986 2 1 1 CD cord-015306-us58wwmp 2986 3 month month NN cord-015306-us58wwmp 2986 4 , , , cord-015306-us58wwmp 2986 5 the the DT cord-015306-us58wwmp 2986 6 concentration concentration NN cord-015306-us58wwmp 2986 7 was be VBD cord-015306-us58wwmp 2986 8 0.34 0.34 CD cord-015306-us58wwmp 2986 9 mg/ mg/ NN cord-015306-us58wwmp 2987 1 mL. mL. NNS cord-015306-us58wwmp 2987 2 We -PRON- PRP cord-015306-us58wwmp 2987 3 switched switch VBD cord-015306-us58wwmp 2987 4 from from IN cord-015306-us58wwmp 2987 5 CDDP CDDP NNP cord-015306-us58wwmp 2987 6 to to IN cord-015306-us58wwmp 2987 7 carboplatin carboplatin NNS cord-015306-us58wwmp 2987 8 , , , cord-015306-us58wwmp 2987 9 and and CC cord-015306-us58wwmp 2987 10 chemotherapy chemotherapy NN cord-015306-us58wwmp 2987 11 was be VBD cord-015306-us58wwmp 2987 12 continued continue VBN cord-015306-us58wwmp 2987 13 for for IN cord-015306-us58wwmp 2987 14 4 4 CD cord-015306-us58wwmp 2987 15 courses course NNS cord-015306-us58wwmp 2987 16 and and CC cord-015306-us58wwmp 2987 17 then then RB cord-015306-us58wwmp 2987 18 radiation radiation NN cord-015306-us58wwmp 2987 19 therapy therapy NN cord-015306-us58wwmp 2987 20 was be VBD cord-015306-us58wwmp 2987 21 added add VBN cord-015306-us58wwmp 2987 22 . . . cord-015306-us58wwmp 2988 1 Ultimately ultimately RB cord-015306-us58wwmp 2988 2 , , , cord-015306-us58wwmp 2988 3 she -PRON- PRP cord-015306-us58wwmp 2988 4 had have VBD cord-015306-us58wwmp 2988 5 mild mild JJ cord-015306-us58wwmp 2988 6 renal renal JJ cord-015306-us58wwmp 2988 7 insufficiency insufficiency NN cord-015306-us58wwmp 2988 8 and and CC cord-015306-us58wwmp 2988 9 moderate moderate JJ cord-015306-us58wwmp 2988 10 hearing hearing NN cord-015306-us58wwmp 2988 11 loss loss NN cord-015306-us58wwmp 2988 12 . . . cord-015306-us58wwmp 2989 1 We -PRON- PRP cord-015306-us58wwmp 2989 2 evaluated evaluate VBD cord-015306-us58wwmp 2989 3 the the DT cord-015306-us58wwmp 2989 4 relationship relationship NN cord-015306-us58wwmp 2989 5 between between IN cord-015306-us58wwmp 2989 6 renal renal JJ cord-015306-us58wwmp 2989 7 function function NN cord-015306-us58wwmp 2989 8 and and CC cord-015306-us58wwmp 2989 9 the the DT cord-015306-us58wwmp 2989 10 CDDP CDDP NNP cord-015306-us58wwmp 2989 11 concentration concentration NN cord-015306-us58wwmp 2989 12 . . . cord-015306-us58wwmp 2990 1 Severe severe JJ cord-015306-us58wwmp 2990 2 renal renal JJ cord-015306-us58wwmp 2990 3 failure failure NN cord-015306-us58wwmp 2990 4 and and CC cord-015306-us58wwmp 2990 5 hyponatremia hyponatremia NN cord-015306-us58wwmp 2990 6 were be VBD cord-015306-us58wwmp 2990 7 observed observe VBN cord-015306-us58wwmp 2990 8 at at IN cord-015306-us58wwmp 2990 9 a a DT cord-015306-us58wwmp 2990 10 CDDP CDDP NNP cord-015306-us58wwmp 2990 11 concentration concentration NN cord-015306-us58wwmp 2990 12 of of IN cord-015306-us58wwmp 2990 13 1 1 CD cord-015306-us58wwmp 2990 14 mg mg NNP cord-015306-us58wwmp 2990 15 / / SYM cord-015306-us58wwmp 2990 16 mL ml NN cord-015306-us58wwmp 2990 17 or or CC cord-015306-us58wwmp 2990 18 more more JJR cord-015306-us58wwmp 2990 19 . . . cord-015306-us58wwmp 2991 1 Creatinine creatinine NN cord-015306-us58wwmp 2991 2 clearance clearance NN cord-015306-us58wwmp 2991 3 of of IN cord-015306-us58wwmp 2991 4 60 60 CD cord-015306-us58wwmp 2991 5 mL ml NN cord-015306-us58wwmp 2991 6 / / SYM cord-015306-us58wwmp 2991 7 min/1.73 min/1.73 JJ cord-015306-us58wwmp 2991 8 m m CD cord-015306-us58wwmp 2991 9 2 2 CD cord-015306-us58wwmp 2991 10 was be VBD cord-015306-us58wwmp 2991 11 maintained maintain VBN cord-015306-us58wwmp 2991 12 at at IN cord-015306-us58wwmp 2991 13 a a DT cord-015306-us58wwmp 2991 14 CDDP CDDP NNP cord-015306-us58wwmp 2991 15 concentration concentration NN cord-015306-us58wwmp 2991 16 below below IN cord-015306-us58wwmp 2991 17 0.5 0.5 CD cord-015306-us58wwmp 2991 18 mg mg NNP cord-015306-us58wwmp 2991 19 / / SYM cord-015306-us58wwmp 2991 20 mL. mL. NNP cord-015306-us58wwmp 2991 21 Conclusion conclusion NN cord-015306-us58wwmp 2991 22 : : : cord-015306-us58wwmp 2991 23 In in IN cord-015306-us58wwmp 2991 24 children child NNS cord-015306-us58wwmp 2991 25 with with IN cord-015306-us58wwmp 2991 26 a a DT cord-015306-us58wwmp 2991 27 CDDP CDDP NNP cord-015306-us58wwmp 2991 28 over over IN cord-015306-us58wwmp 2991 29 - - HYPH cord-015306-us58wwmp 2991 30 dose dose NN cord-015306-us58wwmp 2991 31 , , , cord-015306-us58wwmp 2991 32 plasma plasma NN cord-015306-us58wwmp 2991 33 exchange exchange NN cord-015306-us58wwmp 2991 34 and and CC cord-015306-us58wwmp 2991 35 sodium sodium NN cord-015306-us58wwmp 2991 36 thiosulfate thiosulfate NNP cord-015306-us58wwmp 2991 37 administration administration NN cord-015306-us58wwmp 2991 38 are be VBP cord-015306-us58wwmp 2991 39 effective effective JJ cord-015306-us58wwmp 2991 40 . . . cord-015306-us58wwmp 2992 1 Also also RB cord-015306-us58wwmp 2992 2 , , , cord-015306-us58wwmp 2992 3 monitoring monitoring NN cord-015306-us58wwmp 2992 4 of of IN cord-015306-us58wwmp 2992 5 CDDP CDDP NNP cord-015306-us58wwmp 2992 6 concentrations concentration NNS cord-015306-us58wwmp 2992 7 is be VBZ cord-015306-us58wwmp 2992 8 recommended recommend VBN cord-015306-us58wwmp 2992 9 in in IN cord-015306-us58wwmp 2992 10 patients patient NNS cord-015306-us58wwmp 2992 11 with with IN cord-015306-us58wwmp 2992 12 acute acute JJ cord-015306-us58wwmp 2992 13 renal renal JJ cord-015306-us58wwmp 2992 14 failure failure NN cord-015306-us58wwmp 2992 15 . . . cord-015306-us58wwmp 2993 1 In in IN cord-015306-us58wwmp 2993 2 over over IN cord-015306-us58wwmp 2993 3 - - HYPH cord-015306-us58wwmp 2993 4 dose dose NN cord-015306-us58wwmp 2993 5 patients patient NNS cord-015306-us58wwmp 2993 6 , , , cord-015306-us58wwmp 2993 7 early early JJ cord-015306-us58wwmp 2993 8 severe severe JJ cord-015306-us58wwmp 2993 9 renal renal JJ cord-015306-us58wwmp 2993 10 failure failure NN cord-015306-us58wwmp 2993 11 can can MD cord-015306-us58wwmp 2993 12 be be VB cord-015306-us58wwmp 2993 13 prevented prevent VBN cord-015306-us58wwmp 2993 14 when when WRB cord-015306-us58wwmp 2993 15 the the DT cord-015306-us58wwmp 2993 16 CDDP CDDP NNP cord-015306-us58wwmp 2993 17 concentration concentration NN cord-015306-us58wwmp 2993 18 is be VBZ cord-015306-us58wwmp 2993 19 reduced reduce VBN cord-015306-us58wwmp 2993 20 to to IN cord-015306-us58wwmp 2993 21 less less JJR cord-015306-us58wwmp 2993 22 than than IN cord-015306-us58wwmp 2993 23 0.5 0.5 CD cord-015306-us58wwmp 2993 24 mg mg NNP cord-015306-us58wwmp 2993 25 / / SYM cord-015306-us58wwmp 2993 26 mL ml XX cord-015306-us58wwmp 2993 27 with with IN cord-015306-us58wwmp 2993 28 these these DT cord-015306-us58wwmp 2993 29 therapies therapy NNS cord-015306-us58wwmp 2993 30 . . . cord-015306-us58wwmp 2994 1 Abstract abstract JJ cord-015306-us58wwmp 2994 2 # # NN cord-015306-us58wwmp 2994 3 P p NN cord-015306-us58wwmp 2994 4 - - HYPH cord-015306-us58wwmp 2994 5 SAT331 SAT331 NNP cord-015306-us58wwmp 2994 6 Peritoneal Peritoneal NNP cord-015306-us58wwmp 2994 7 Dialysis Dialysis NNP cord-015306-us58wwmp 2994 8 in in IN cord-015306-us58wwmp 2994 9 Children Children NNP cord-015306-us58wwmp 2994 10 with with IN cord-015306-us58wwmp 2994 11 Acute acute JJ cord-015306-us58wwmp 2994 12 Kidney Kidney NNP cord-015306-us58wwmp 2994 13 Injury injury NN cord-015306-us58wwmp 2994 14 : : : cord-015306-us58wwmp 2995 1 A a DT cord-015306-us58wwmp 2995 2 Developing develop VBG cord-015306-us58wwmp 2995 3 country country NN cord-015306-us58wwmp 2995 4 experience experience NN cord-015306-us58wwmp 2995 5 Om Om NNP cord-015306-us58wwmp 2995 6 P P NNP cord-015306-us58wwmp 2995 7 Mishra Mishra NNP cord-015306-us58wwmp 2995 8 1 1 CD cord-015306-us58wwmp 2995 9 , , , cord-015306-us58wwmp 2995 10 Aditya Aditya NNP cord-015306-us58wwmp 2995 11 K K NNP cord-015306-us58wwmp 2995 12 Gupta Gupta NNP cord-015306-us58wwmp 2995 13 1 1 CD cord-015306-us58wwmp 2995 14 , , , cord-015306-us58wwmp 2995 15 Vishal Vishal NNP cord-015306-us58wwmp 2995 16 Pooniya Pooniya NNP cord-015306-us58wwmp 2995 17 1 1 CD cord-015306-us58wwmp 2995 18 , , , cord-015306-us58wwmp 2995 19 Rajniti Rajniti NNP cord-015306-us58wwmp 2995 20 Prasad Prasad NNP cord-015306-us58wwmp 2995 21 1 1 CD cord-015306-us58wwmp 2995 22 , , , cord-015306-us58wwmp 2995 23 Narendra Narendra NNP cord-015306-us58wwmp 2995 24 K K NNP cord-015306-us58wwmp 2995 25 Tiwary Tiwary NNP cord-015306-us58wwmp 2995 26 1 1 CD cord-015306-us58wwmp 2995 27 , , , cord-015306-us58wwmp 2995 28 Franz Franz NNP cord-015306-us58wwmp 2995 29 Schaefer Schaefer NNP cord-015306-us58wwmp 2995 30 2 2 CD cord-015306-us58wwmp 2995 31 1 1 CD cord-015306-us58wwmp 2995 32 Pediatrics Pediatrics NNP cord-015306-us58wwmp 2995 33 and and CC cord-015306-us58wwmp 2995 34 Medicine Medicine NNP cord-015306-us58wwmp 2995 35 , , , cord-015306-us58wwmp 2995 36 Institute Institute NNP cord-015306-us58wwmp 2995 37 of of IN cord-015306-us58wwmp 2995 38 Medical Medical NNP cord-015306-us58wwmp 2995 39 Sciences Sciences NNPS cord-015306-us58wwmp 2995 40 , , , cord-015306-us58wwmp 2995 41 Varanasi Varanasi NNP cord-015306-us58wwmp 2995 42 , , , cord-015306-us58wwmp 2995 43 India India NNP cord-015306-us58wwmp 2995 44 2 2 CD cord-015306-us58wwmp 2995 45 Division Division NNP cord-015306-us58wwmp 2995 46 of of IN cord-015306-us58wwmp 2995 47 Pediatric Pediatric NNP cord-015306-us58wwmp 2995 48 Nephrology Nephrology NNP cord-015306-us58wwmp 2995 49 , , , cord-015306-us58wwmp 2995 50 Heidelberg Heidelberg NNP cord-015306-us58wwmp 2995 51 University University NNP cord-015306-us58wwmp 2995 52 Medical Medical NNP cord-015306-us58wwmp 2995 53 Centre Centre NNP cord-015306-us58wwmp 2995 54 , , , cord-015306-us58wwmp 2995 55 Heidelberg Heidelberg NNP cord-015306-us58wwmp 2995 56 , , , cord-015306-us58wwmp 2996 1 Germany Germany NNP cord-015306-us58wwmp 2996 2 Objective Objective NNP cord-015306-us58wwmp 2996 3 : : : cord-015306-us58wwmp 2996 4 Peritoneal peritoneal JJ cord-015306-us58wwmp 2996 5 dialysis dialysis NN cord-015306-us58wwmp 2996 6 ( ( -LRB- cord-015306-us58wwmp 2996 7 PD PD NNP cord-015306-us58wwmp 2996 8 ) ) -RRB- cord-015306-us58wwmp 2996 9 is be VBZ cord-015306-us58wwmp 2996 10 the the DT cord-015306-us58wwmp 2996 11 preferred preferred JJ cord-015306-us58wwmp 2996 12 and and CC cord-015306-us58wwmp 2996 13 convenient convenient JJ cord-015306-us58wwmp 2996 14 treatment treatment NN cord-015306-us58wwmp 2996 15 modality modality NN cord-015306-us58wwmp 2996 16 for for IN cord-015306-us58wwmp 2996 17 acute acute JJ cord-015306-us58wwmp 2996 18 kidney kidney NN cord-015306-us58wwmp 2996 19 injury injury NN cord-015306-us58wwmp 2996 20 ( ( -LRB- cord-015306-us58wwmp 2996 21 AKI AKI NNP cord-015306-us58wwmp 2996 22 ) ) -RRB- cord-015306-us58wwmp 2996 23 in in IN cord-015306-us58wwmp 2996 24 children child NNS cord-015306-us58wwmp 2996 25 and and CC cord-015306-us58wwmp 2996 26 hemodynamically hemodynamically RB cord-015306-us58wwmp 2996 27 unstable unstable JJ cord-015306-us58wwmp 2996 28 patients patient NNS cord-015306-us58wwmp 2996 29 . . . cord-015306-us58wwmp 2997 1 The the DT cord-015306-us58wwmp 2997 2 present present JJ cord-015306-us58wwmp 2997 3 study study NN cord-015306-us58wwmp 2997 4 analyzed analyze VBD cord-015306-us58wwmp 2997 5 the the DT cord-015306-us58wwmp 2997 6 efficacy efficacy NN cord-015306-us58wwmp 2997 7 of of IN cord-015306-us58wwmp 2997 8 PD PD NNP cord-015306-us58wwmp 2997 9 in in IN cord-015306-us58wwmp 2997 10 patients patient NNS cord-015306-us58wwmp 2997 11 with with IN cord-015306-us58wwmp 2997 12 AKI AKI NNP cord-015306-us58wwmp 2997 13 and and CC cord-015306-us58wwmp 2997 14 factors factor NNS cord-015306-us58wwmp 2997 15 contributing contribute VBG cord-015306-us58wwmp 2997 16 to to IN cord-015306-us58wwmp 2997 17 mortality mortality NN cord-015306-us58wwmp 2997 18 . . . cord-015306-us58wwmp 2998 1 Methods method NNS cord-015306-us58wwmp 2998 2 : : : cord-015306-us58wwmp 2998 3 The the DT cord-015306-us58wwmp 2998 4 outcome outcome NN cord-015306-us58wwmp 2998 5 of of IN cord-015306-us58wwmp 2998 6 acute acute JJ cord-015306-us58wwmp 2998 7 PD PD NNP cord-015306-us58wwmp 2998 8 was be VBD cord-015306-us58wwmp 2998 9 studied study VBN cord-015306-us58wwmp 2998 10 in in IN cord-015306-us58wwmp 2998 11 57 57 CD cord-015306-us58wwmp 2998 12 children child NNS cord-015306-us58wwmp 2998 13 ( ( -LRB- cord-015306-us58wwmp 2998 14 39 39 CD cord-015306-us58wwmp 2998 15 males male NNS cord-015306-us58wwmp 2998 16 ) ) -RRB- cord-015306-us58wwmp 2998 17 with with IN cord-015306-us58wwmp 2998 18 AKI AKI NNP cord-015306-us58wwmp 2998 19 , , , cord-015306-us58wwmp 2998 20 aged aged JJ cord-015306-us58wwmp 2998 21 1 1 CD cord-015306-us58wwmp 2998 22 month month NN cord-015306-us58wwmp 2998 23 to to IN cord-015306-us58wwmp 2998 24 12 12 CD cord-015306-us58wwmp 2998 25 years year NNS cord-015306-us58wwmp 2998 26 , , , cord-015306-us58wwmp 2998 27 at at IN cord-015306-us58wwmp 2998 28 a a DT cord-015306-us58wwmp 2998 29 tertiary tertiary JJ cord-015306-us58wwmp 2998 30 care care NN cord-015306-us58wwmp 2998 31 centre centre NN cord-015306-us58wwmp 2998 32 of of IN cord-015306-us58wwmp 2998 33 a a DT cord-015306-us58wwmp 2998 34 teaching teaching NN cord-015306-us58wwmp 2998 35 hospital hospital NN cord-015306-us58wwmp 2998 36 in in IN cord-015306-us58wwmp 2998 37 India India NNP cord-015306-us58wwmp 2998 38 . . . cord-015306-us58wwmp 2999 1 Results result NNS cord-015306-us58wwmp 2999 2 : : : cord-015306-us58wwmp 3000 1 There there EX cord-015306-us58wwmp 3000 2 were be VBD cord-015306-us58wwmp 3000 3 14 14 CD cord-015306-us58wwmp 3000 4 patients patient NNS cord-015306-us58wwmp 3000 5 less less JJR cord-015306-us58wwmp 3000 6 than than IN cord-015306-us58wwmp 3000 7 1 1 CD cord-015306-us58wwmp 3000 8 year year NN cord-015306-us58wwmp 3000 9 of of IN cord-015306-us58wwmp 3000 10 age age NN cord-015306-us58wwmp 3000 11 , , , cord-015306-us58wwmp 3000 12 23 23 CD cord-015306-us58wwmp 3000 13 patients patient NNS cord-015306-us58wwmp 3000 14 1 1 CD cord-015306-us58wwmp 3000 15 - - SYM cord-015306-us58wwmp 3000 16 5 5 CD cord-015306-us58wwmp 3000 17 years year NNS cord-015306-us58wwmp 3000 18 of of IN cord-015306-us58wwmp 3000 19 age age NN cord-015306-us58wwmp 3000 20 , , , cord-015306-us58wwmp 3000 21 and and CC cord-015306-us58wwmp 3000 22 20 20 CD cord-015306-us58wwmp 3000 23 patients patient NNS cord-015306-us58wwmp 3000 24 more more JJR cord-015306-us58wwmp 3000 25 than than IN cord-015306-us58wwmp 3000 26 5 5 CD cord-015306-us58wwmp 3000 27 years year NNS cord-015306-us58wwmp 3000 28 of of IN cord-015306-us58wwmp 3000 29 age age NN cord-015306-us58wwmp 3000 30 . . . cord-015306-us58wwmp 3001 1 Per per IN cord-015306-us58wwmp 3001 2 the the DT cord-015306-us58wwmp 3001 3 RIFLE rifle NN cord-015306-us58wwmp 3001 4 criteria criterion NNS cord-015306-us58wwmp 3001 5 , , , cord-015306-us58wwmp 3001 6 5 5 CD cord-015306-us58wwmp 3001 7 patients patient NNS cord-015306-us58wwmp 3001 8 were be VBD cord-015306-us58wwmp 3001 9 classified classify VBN cord-015306-us58wwmp 3001 10 at at IN cord-015306-us58wwmp 3001 11 the the DT cord-015306-us58wwmp 3001 12 Risk Risk NNP cord-015306-us58wwmp 3001 13 stage stage NN cord-015306-us58wwmp 3001 14 ; ; : cord-015306-us58wwmp 3001 15 13 13 CD cord-015306-us58wwmp 3001 16 , , , cord-015306-us58wwmp 3001 17 at at IN cord-015306-us58wwmp 3001 18 the the DT cord-015306-us58wwmp 3001 19 Injury injury NN cord-015306-us58wwmp 3001 20 stage stage NN cord-015306-us58wwmp 3001 21 ; ; : cord-015306-us58wwmp 3001 22 and and CC cord-015306-us58wwmp 3001 23 39 39 CD cord-015306-us58wwmp 3001 24 , , , cord-015306-us58wwmp 3001 25 at at IN cord-015306-us58wwmp 3001 26 the the DT cord-015306-us58wwmp 3001 27 Failure Failure NNP cord-015306-us58wwmp 3001 28 stage stage NN cord-015306-us58wwmp 3001 29 at at IN cord-015306-us58wwmp 3001 30 the the DT cord-015306-us58wwmp 3001 31 time time NN cord-015306-us58wwmp 3001 32 of of IN cord-015306-us58wwmp 3001 33 the the DT cord-015306-us58wwmp 3001 34 decision decision NN cord-015306-us58wwmp 3001 35 to to TO cord-015306-us58wwmp 3001 36 start start VB cord-015306-us58wwmp 3001 37 PD PD NNP cord-015306-us58wwmp 3001 38 . . . cord-015306-us58wwmp 3002 1 Hemolytic hemolytic JJ cord-015306-us58wwmp 3002 2 uremic uremic JJ cord-015306-us58wwmp 3002 3 syndrome syndrome NN cord-015306-us58wwmp 3002 4 was be VBD cord-015306-us58wwmp 3002 5 the the DT cord-015306-us58wwmp 3002 6 most most RBS cord-015306-us58wwmp 3002 7 common common JJ cord-015306-us58wwmp 3002 8 cause cause NN cord-015306-us58wwmp 3002 9 of of IN cord-015306-us58wwmp 3002 10 AKI AKI NNP cord-015306-us58wwmp 3002 11 ( ( -LRB- cord-015306-us58wwmp 3002 12 36.8 36.8 CD cord-015306-us58wwmp 3002 13 % % NN cord-015306-us58wwmp 3002 14 ) ) -RRB- cord-015306-us58wwmp 3002 15 , , , cord-015306-us58wwmp 3002 16 followed follow VBN cord-015306-us58wwmp 3002 17 by by IN cord-015306-us58wwmp 3002 18 septicemia septicemia NN cord-015306-us58wwmp 3002 19 ( ( -LRB- cord-015306-us58wwmp 3002 20 24.6 24.6 CD cord-015306-us58wwmp 3002 21 % % NN cord-015306-us58wwmp 3002 22 ) ) -RRB- cord-015306-us58wwmp 3002 23 and and CC cord-015306-us58wwmp 3002 24 acute acute JJ cord-015306-us58wwmp 3002 25 tubular tubular JJ cord-015306-us58wwmp 3002 26 necrosis necrosis NN cord-015306-us58wwmp 3002 27 ( ( -LRB- cord-015306-us58wwmp 3002 28 19.3 19.3 CD cord-015306-us58wwmp 3002 29 % % NN cord-015306-us58wwmp 3002 30 ) ) -RRB- cord-015306-us58wwmp 3002 31 . . . cord-015306-us58wwmp 3003 1 Treatment treatment NN cord-015306-us58wwmp 3003 2 with with IN cord-015306-us58wwmp 3003 3 PD PD NNP cord-015306-us58wwmp 3003 4 was be VBD cord-015306-us58wwmp 3003 5 highly highly RB cord-015306-us58wwmp 3003 6 effective effective JJ cord-015306-us58wwmp 3003 7 in in IN cord-015306-us58wwmp 3003 8 lowering lower VBG cord-015306-us58wwmp 3003 9 retention retention NN cord-015306-us58wwmp 3003 10 markers marker NNS cord-015306-us58wwmp 3003 11 ( ( -LRB- cord-015306-us58wwmp 3003 12 blood blood NN cord-015306-us58wwmp 3003 13 urea urea NN cord-015306-us58wwmp 3003 14 decreased decrease VBD cord-015306-us58wwmp 3003 15 by by IN cord-015306-us58wwmp 3003 16 40 40 CD cord-015306-us58wwmp 3003 17 % % NN cord-015306-us58wwmp 3003 18 and and CC cord-015306-us58wwmp 3003 19 serum serum NN cord-015306-us58wwmp 3003 20 creatinine creatinine NN cord-015306-us58wwmp 3003 21 by by IN cord-015306-us58wwmp 3003 22 34 34 CD cord-015306-us58wwmp 3003 23 % % NN cord-015306-us58wwmp 3003 24 during during IN cord-015306-us58wwmp 3003 25 the the DT cord-015306-us58wwmp 3003 26 course course NN cord-015306-us58wwmp 3003 27 of of IN cord-015306-us58wwmp 3003 28 dialysis dialysis NN cord-015306-us58wwmp 3003 29 therapy therapy NN cord-015306-us58wwmp 3003 30 , , , cord-015306-us58wwmp 3003 31 both both DT cord-015306-us58wwmp 3003 32 trends trend NNS cord-015306-us58wwmp 3003 33 significant significant JJ cord-015306-us58wwmp 3003 34 at at IN cord-015306-us58wwmp 3003 35 p p NN cord-015306-us58wwmp 3003 36 < < XX cord-015306-us58wwmp 3003 37 0.001 0.001 CD cord-015306-us58wwmp 3003 38 ) ) -RRB- cord-015306-us58wwmp 3003 39 . . . cord-015306-us58wwmp 3004 1 Overall overall JJ cord-015306-us58wwmp 3004 2 mortality mortality NN cord-015306-us58wwmp 3004 3 was be VBD cord-015306-us58wwmp 3004 4 36.8 36.8 CD cord-015306-us58wwmp 3004 5 % % NN cord-015306-us58wwmp 3004 6 . . . cord-015306-us58wwmp 3005 1 Deaths death NNS cord-015306-us58wwmp 3005 2 occurred occur VBD cord-015306-us58wwmp 3005 3 2 2 CD cord-015306-us58wwmp 3005 4 - - SYM cord-015306-us58wwmp 3005 5 7 7 CD cord-015306-us58wwmp 3005 6 days day NNS cord-015306-us58wwmp 3005 7 after after IN cord-015306-us58wwmp 3005 8 hospitalization hospitalization NN cord-015306-us58wwmp 3005 9 . . . cord-015306-us58wwmp 3006 1 Significantly significantly RB cord-015306-us58wwmp 3006 2 higher high JJR cord-015306-us58wwmp 3006 3 proportion proportion NN cord-015306-us58wwmp 3006 4 of of IN cord-015306-us58wwmp 3006 5 non non JJ cord-015306-us58wwmp 3006 6 - - NNS cord-015306-us58wwmp 3006 7 survivors survivor NNS cord-015306-us58wwmp 3006 8 had have VBD cord-015306-us58wwmp 3006 9 fluid fluid JJ cord-015306-us58wwmp 3006 10 overload overload NN cord-015306-us58wwmp 3006 11 ( ( -LRB- cord-015306-us58wwmp 3006 12 66.7 66.7 CD cord-015306-us58wwmp 3006 13 % % NN cord-015306-us58wwmp 3006 14 vs vs IN cord-015306-us58wwmp 3006 15 25 25 CD cord-015306-us58wwmp 3006 16 % % NN cord-015306-us58wwmp 3006 17 , , , cord-015306-us58wwmp 3006 18 p= p= NNP cord-015306-us58wwmp 3006 19 0.002 0.002 CD cord-015306-us58wwmp 3006 20 ) ) -RRB- cord-015306-us58wwmp 3006 21 and and CC cord-015306-us58wwmp 3006 22 septicemia septicemia NN cord-015306-us58wwmp 3006 23 ( ( -LRB- cord-015306-us58wwmp 3006 24 47.6 47.6 CD cord-015306-us58wwmp 3006 25 % % NN cord-015306-us58wwmp 3006 26 vs vs IN cord-015306-us58wwmp 3006 27 11.1 11.1 CD cord-015306-us58wwmp 3006 28 % % NN cord-015306-us58wwmp 3006 29 , , , cord-015306-us58wwmp 3006 30 p p NN cord-015306-us58wwmp 3006 31 < < XX cord-015306-us58wwmp 3006 32 0.001 0.001 CD cord-015306-us58wwmp 3006 33 ) ) -RRB- cord-015306-us58wwmp 3006 34 than than IN cord-015306-us58wwmp 3006 35 survivors survivor NNS cord-015306-us58wwmp 3006 36 at at IN cord-015306-us58wwmp 3006 37 presentation presentation NN cord-015306-us58wwmp 3006 38 . . . cord-015306-us58wwmp 3007 1 The the DT cord-015306-us58wwmp 3007 2 risk risk NN cord-015306-us58wwmp 3007 3 of of IN cord-015306-us58wwmp 3007 4 mortality mortality NN cord-015306-us58wwmp 3007 5 by by IN cord-015306-us58wwmp 3007 6 multivariate multivariate JJ cord-015306-us58wwmp 3007 7 analysis analysis NN cord-015306-us58wwmp 3007 8 was be VBD cord-015306-us58wwmp 3007 9 higher high JJR cord-015306-us58wwmp 3007 10 when when WRB cord-015306-us58wwmp 3007 11 patients patient NNS cord-015306-us58wwmp 3007 12 were be VBD cord-015306-us58wwmp 3007 13 anuric anuric JJ cord-015306-us58wwmp 3008 1 [ [ -LRB- cord-015306-us58wwmp 3008 2 Odds odd NNS cord-015306-us58wwmp 3008 3 ratio ratio NN cord-015306-us58wwmp 3008 4 ( ( -LRB- cord-015306-us58wwmp 3008 5 OR or CC cord-015306-us58wwmp 3008 6 ) ) -RRB- cord-015306-us58wwmp 3008 7 8.2 8.2 CD cord-015306-us58wwmp 3008 8 , , , cord-015306-us58wwmp 3008 9 95 95 CD cord-015306-us58wwmp 3008 10 % % NN cord-015306-us58wwmp 3008 11 confidence confidence NN cord-015306-us58wwmp 3008 12 interval interval NN cord-015306-us58wwmp 3008 13 ( ( -LRB- cord-015306-us58wwmp 3008 14 CI CI NNP cord-015306-us58wwmp 3008 15 ) ) -RRB- cord-015306-us58wwmp 3008 16 1.3 1.3 CD cord-015306-us58wwmp 3008 17 - - SYM cord-015306-us58wwmp 3008 18 49 49 CD cord-015306-us58wwmp 3008 19 , , , cord-015306-us58wwmp 3008 20 p<0.05 p<0.05 CD cord-015306-us58wwmp 3008 21 ) ) -RRB- cord-015306-us58wwmp 3008 22 , , , cord-015306-us58wwmp 3008 23 had have VBD cord-015306-us58wwmp 3008 24 septicemia septicemia NN cord-015306-us58wwmp 3008 25 ( ( -LRB- cord-015306-us58wwmp 3008 26 OR or CC cord-015306-us58wwmp 3008 27 3.79 3.79 CD cord-015306-us58wwmp 3008 28 , , , cord-015306-us58wwmp 3008 29 95 95 CD cord-015306-us58wwmp 3008 30 % % NN cord-015306-us58wwmp 3008 31 CI CI NNP cord-015306-us58wwmp 3008 32 1.55 1.55 CD cord-015306-us58wwmp 3008 33 - - HYPH cord-015306-us58wwmp 3008 34 25.8 25.8 CD cord-015306-us58wwmp 3008 35 , , , cord-015306-us58wwmp 3008 36 p<0.05 p<0.05 CD cord-015306-us58wwmp 3008 37 ) ) -RRB- cord-015306-us58wwmp 3008 38 , , , cord-015306-us58wwmp 3008 39 or or CC cord-015306-us58wwmp 3008 40 severe severe JJ cord-015306-us58wwmp 3008 41 infectious infectious JJ cord-015306-us58wwmp 3008 42 complications complication NNS cord-015306-us58wwmp 3008 43 ( ( -LRB- cord-015306-us58wwmp 3008 44 OR or CC cord-015306-us58wwmp 3009 1 8.2 8.2 CD cord-015306-us58wwmp 3009 2 , , , cord-015306-us58wwmp 3009 3 95 95 CD cord-015306-us58wwmp 3009 4 % % NN cord-015306-us58wwmp 3009 5 CI CI NNP cord-015306-us58wwmp 3009 6 1.5 1.5 CD cord-015306-us58wwmp 3009 7 - - HYPH cord-015306-us58wwmp 3009 8 42.9 42.9 CD cord-015306-us58wwmp 3009 9 , , , cord-015306-us58wwmp 3009 10 p<001 p<001 NNP cord-015306-us58wwmp 3009 11 ) ) -RRB- cord-015306-us58wwmp 3009 12 . . . cord-015306-us58wwmp 3010 1 Conclusion conclusion NN cord-015306-us58wwmp 3010 2 : : : cord-015306-us58wwmp 3011 1 Because because IN cord-015306-us58wwmp 3011 2 of of IN cord-015306-us58wwmp 3011 3 its -PRON- PRP$ cord-015306-us58wwmp 3011 4 simplicity simplicity NN cord-015306-us58wwmp 3011 5 and and CC cord-015306-us58wwmp 3011 6 feasibility feasibility NN cord-015306-us58wwmp 3011 7 , , , cord-015306-us58wwmp 3011 8 acute acute JJ cord-015306-us58wwmp 3011 9 PD PD NNP cord-015306-us58wwmp 3011 10 is be VBZ cord-015306-us58wwmp 3011 11 still still RB cord-015306-us58wwmp 3011 12 an an DT cord-015306-us58wwmp 3011 13 appropriate appropriate JJ cord-015306-us58wwmp 3011 14 treatment treatment NN cord-015306-us58wwmp 3011 15 choice choice NN cord-015306-us58wwmp 3011 16 for for IN cord-015306-us58wwmp 3011 17 children child NNS cord-015306-us58wwmp 3011 18 with with IN cord-015306-us58wwmp 3011 19 AKI AKI NNP cord-015306-us58wwmp 3011 20 in in IN cord-015306-us58wwmp 3011 21 resource resource NN cord-015306-us58wwmp 3011 22 - - HYPH cord-015306-us58wwmp 3011 23 poor poor JJ cord-015306-us58wwmp 3011 24 settings setting NNS cord-015306-us58wwmp 3011 25 . . . cord-015306-us58wwmp 3012 1 Septicemia septicemia NN cord-015306-us58wwmp 3012 2 and and CC cord-015306-us58wwmp 3012 3 severity severity NN cord-015306-us58wwmp 3012 4 of of IN cord-015306-us58wwmp 3012 5 AKI AKI NNP cord-015306-us58wwmp 3012 6 are be VBP cord-015306-us58wwmp 3012 7 contributory contributory JJ cord-015306-us58wwmp 3012 8 factors factor NNS cord-015306-us58wwmp 3012 9 to to IN cord-015306-us58wwmp 3012 10 high high JJ cord-015306-us58wwmp 3012 11 mortality mortality NN cord-015306-us58wwmp 3012 12 in in IN cord-015306-us58wwmp 3012 13 pediatric pediatric JJ cord-015306-us58wwmp 3012 14 acute acute JJ cord-015306-us58wwmp 3012 15 kidney kidney NN cord-015306-us58wwmp 3012 16 injury injury NN cord-015306-us58wwmp 3012 17 . . . cord-015306-us58wwmp 3013 1 Outcome outcome NN cord-015306-us58wwmp 3013 2 of of IN cord-015306-us58wwmp 3013 3 Acute acute JJ cord-015306-us58wwmp 3013 4 Kidney Kidney NNP cord-015306-us58wwmp 3013 5 Injury Injury NNP cord-015306-us58wwmp 3013 6 managed manage VBD cord-015306-us58wwmp 3013 7 in in IN cord-015306-us58wwmp 3013 8 a a DT cord-015306-us58wwmp 3013 9 regional regional JJ cord-015306-us58wwmp 3013 10 paediatric paediatric JJ cord-015306-us58wwmp 3013 11 nephrology nephrology NN cord-015306-us58wwmp 3013 12 centre centre NN cord-015306-us58wwmp 3013 13 Shivaram Shivaram NNP cord-015306-us58wwmp 3013 14 Hegde Hegde NNP cord-015306-us58wwmp 3013 15 , , , cord-015306-us58wwmp 3013 16 Sabina Sabina NNP cord-015306-us58wwmp 3013 17 Pahari Pahari NNP cord-015306-us58wwmp 3013 18 Paediatric Paediatric NNP cord-015306-us58wwmp 3013 19 nephrology nephrology NN cord-015306-us58wwmp 3013 20 , , , cord-015306-us58wwmp 3013 21 University University NNP cord-015306-us58wwmp 3013 22 Hospital Hospital NNP cord-015306-us58wwmp 3013 23 of of IN cord-015306-us58wwmp 3013 24 Wales Wales NNP cord-015306-us58wwmp 3013 25 , , , cord-015306-us58wwmp 3013 26 Cardiff Cardiff NNP cord-015306-us58wwmp 3013 27 , , , cord-015306-us58wwmp 3014 1 UK UK NNP cord-015306-us58wwmp 3014 2 Objective Objective NNP cord-015306-us58wwmp 3014 3 : : : cord-015306-us58wwmp 3015 1 This this DT cord-015306-us58wwmp 3015 2 study study NN cord-015306-us58wwmp 3015 3 reviewed review VBD cord-015306-us58wwmp 3015 4 the the DT cord-015306-us58wwmp 3015 5 aetiology aetiology NN cord-015306-us58wwmp 3015 6 , , , cord-015306-us58wwmp 3015 7 treatment treatment NN cord-015306-us58wwmp 3015 8 modalities modality NNS cord-015306-us58wwmp 3015 9 and and CC cord-015306-us58wwmp 3015 10 outcome outcome NN cord-015306-us58wwmp 3015 11 of of IN cord-015306-us58wwmp 3015 12 children child NNS cord-015306-us58wwmp 3015 13 with with IN cord-015306-us58wwmp 3015 14 AKI AKI NNP cord-015306-us58wwmp 3015 15 managed manage VBD cord-015306-us58wwmp 3015 16 in in IN cord-015306-us58wwmp 3015 17 our -PRON- PRP$ cord-015306-us58wwmp 3015 18 tertiary tertiary JJ cord-015306-us58wwmp 3015 19 paediatric paediatric JJ cord-015306-us58wwmp 3015 20 nephrology nephrology NN cord-015306-us58wwmp 3015 21 unit unit NN cord-015306-us58wwmp 3015 22 . . . cord-015306-us58wwmp 3016 1 Method method NN cord-015306-us58wwmp 3016 2 : : : cord-015306-us58wwmp 3017 1 Retrospective retrospective JJ cord-015306-us58wwmp 3017 2 analysis analysis NN cord-015306-us58wwmp 3017 3 of of IN cord-015306-us58wwmp 3017 4 referral referral JJ cord-015306-us58wwmp 3017 5 practices practice NNS cord-015306-us58wwmp 3017 6 , , , cord-015306-us58wwmp 3017 7 aetiology aetiology NN cord-015306-us58wwmp 3017 8 , , , cord-015306-us58wwmp 3017 9 and and CC cord-015306-us58wwmp 3017 10 management management NN cord-015306-us58wwmp 3017 11 of of IN cord-015306-us58wwmp 3017 12 38 38 CD cord-015306-us58wwmp 3017 13 children child NNS cord-015306-us58wwmp 3017 14 treated treat VBN cord-015306-us58wwmp 3017 15 for for IN cord-015306-us58wwmp 3017 16 AKI AKI NNP cord-015306-us58wwmp 3017 17 over over IN cord-015306-us58wwmp 3017 18 the the DT cord-015306-us58wwmp 3017 19 last last JJ cord-015306-us58wwmp 3017 20 5 5 CD cord-015306-us58wwmp 3017 21 years year NNS cord-015306-us58wwmp 3017 22 . . . cord-015306-us58wwmp 3018 1 Children child NNS cord-015306-us58wwmp 3018 2 primarily primarily RB cord-015306-us58wwmp 3018 3 treated treat VBN cord-015306-us58wwmp 3018 4 in in IN cord-015306-us58wwmp 3018 5 intensive intensive JJ cord-015306-us58wwmp 3018 6 care care NN cord-015306-us58wwmp 3018 7 units unit NNS cord-015306-us58wwmp 3018 8 were be VBD cord-015306-us58wwmp 3018 9 excluded exclude VBN cord-015306-us58wwmp 3018 10 . . . cord-015306-us58wwmp 3019 1 Outcomes outcome NNS cord-015306-us58wwmp 3019 2 noted note VBD cord-015306-us58wwmp 3019 3 as as IN cord-015306-us58wwmp 3019 4 complete complete JJ cord-015306-us58wwmp 3019 5 recovery recovery NN cord-015306-us58wwmp 3019 6 , , , cord-015306-us58wwmp 3019 7 residual residual JJ cord-015306-us58wwmp 3019 8 renal renal JJ cord-015306-us58wwmp 3019 9 injury injury NN cord-015306-us58wwmp 3019 10 , , , cord-015306-us58wwmp 3019 11 renal renal JJ cord-015306-us58wwmp 3019 12 replacement replacement NN cord-015306-us58wwmp 3019 13 therapy therapy NN cord-015306-us58wwmp 3019 14 ( ( -LRB- cord-015306-us58wwmp 3019 15 RRT rrt NN cord-015306-us58wwmp 3019 16 ) ) -RRB- cord-015306-us58wwmp 3019 17 dependency dependency NN cord-015306-us58wwmp 3019 18 or or CC cord-015306-us58wwmp 3019 19 death death NN cord-015306-us58wwmp 3019 20 . . . cord-015306-us58wwmp 3020 1 They -PRON- PRP cord-015306-us58wwmp 3020 2 were be VBD cord-015306-us58wwmp 3020 3 followed follow VBN cord-015306-us58wwmp 3020 4 up up RP cord-015306-us58wwmp 3020 5 until until IN cord-015306-us58wwmp 3020 6 their -PRON- PRP$ cord-015306-us58wwmp 3020 7 renal renal JJ cord-015306-us58wwmp 3020 8 function function NN cord-015306-us58wwmp 3020 9 normalised normalise VBN cord-015306-us58wwmp 3020 10 and and CC cord-015306-us58wwmp 3020 11 any any DT cord-015306-us58wwmp 3020 12 proteinuria proteinuria NN cord-015306-us58wwmp 3020 13 or or CC cord-015306-us58wwmp 3020 14 hypertension hypertension NN cord-015306-us58wwmp 3020 15 resolved resolve VBN cord-015306-us58wwmp 3020 16 . . . cord-015306-us58wwmp 3021 1 Result result NN cord-015306-us58wwmp 3021 2 : : : cord-015306-us58wwmp 3022 1 Out out IN cord-015306-us58wwmp 3022 2 of of IN cord-015306-us58wwmp 3022 3 the the DT cord-015306-us58wwmp 3022 4 total total JJ cord-015306-us58wwmp 3022 5 38 38 CD cord-015306-us58wwmp 3022 6 children child NNS cord-015306-us58wwmp 3022 7 aged age VBN cord-015306-us58wwmp 3022 8 5 5 CD cord-015306-us58wwmp 3022 9 months month NNS cord-015306-us58wwmp 3022 10 to to IN cord-015306-us58wwmp 3022 11 16 16 CD cord-015306-us58wwmp 3022 12 years year NNS cord-015306-us58wwmp 3022 13 , , , cord-015306-us58wwmp 3022 14 34 34 CD cord-015306-us58wwmp 3022 15 % % NN cord-015306-us58wwmp 3022 16 were be VBD cord-015306-us58wwmp 3022 17 under under IN cord-015306-us58wwmp 3022 18 5 5 CD cord-015306-us58wwmp 3022 19 years year NNS cord-015306-us58wwmp 3022 20 . . . cord-015306-us58wwmp 3023 1 Haemolytic haemolytic JJ cord-015306-us58wwmp 3023 2 Uremic Uremic NNP cord-015306-us58wwmp 3023 3 syndrome syndrome NN cord-015306-us58wwmp 3023 4 ( ( -LRB- cord-015306-us58wwmp 3023 5 HUS HUS NNP cord-015306-us58wwmp 3023 6 ) ) -RRB- cord-015306-us58wwmp 3023 7 was be VBD cord-015306-us58wwmp 3023 8 the the DT cord-015306-us58wwmp 3023 9 commonest common JJS cord-015306-us58wwmp 3023 10 aetiology aetiology NN cord-015306-us58wwmp 3023 11 in in IN cord-015306-us58wwmp 3023 12 18 18 CD cord-015306-us58wwmp 3023 13 cases case NNS cord-015306-us58wwmp 3023 14 ( ( -LRB- cord-015306-us58wwmp 3023 15 47 47 CD cord-015306-us58wwmp 3023 16 % % NN cord-015306-us58wwmp 3023 17 ) ) -RRB- cord-015306-us58wwmp 3023 18 , , , cord-015306-us58wwmp 3023 19 15 15 CD cord-015306-us58wwmp 3023 20 of of IN cord-015306-us58wwmp 3023 21 them -PRON- PRP cord-015306-us58wwmp 3023 22 secondary secondary JJ cord-015306-us58wwmp 3023 23 to to IN cord-015306-us58wwmp 3023 24 Ecoli Ecoli NNP cord-015306-us58wwmp 3023 25 0157 0157 CD cord-015306-us58wwmp 3023 26 and and CC cord-015306-us58wwmp 3023 27 3 3 CD cord-015306-us58wwmp 3023 28 with with IN cord-015306-us58wwmp 3023 29 atypical atypical JJ cord-015306-us58wwmp 3023 30 HUS hus NN cord-015306-us58wwmp 3023 31 . . . cord-015306-us58wwmp 3024 1 Obstruction obstruction NN cord-015306-us58wwmp 3024 2 was be VBD cord-015306-us58wwmp 3024 3 second second RB cord-015306-us58wwmp 3024 4 most most RBS cord-015306-us58wwmp 3024 5 common common JJ cord-015306-us58wwmp 3024 6 ( ( -LRB- cord-015306-us58wwmp 3024 7 5 5 CD cord-015306-us58wwmp 3024 8 ) ) -RRB- cord-015306-us58wwmp 3024 9 and and CC cord-015306-us58wwmp 3024 10 renal renal JJ cord-015306-us58wwmp 3024 11 function function NN cord-015306-us58wwmp 3024 12 improved improve VBD cord-015306-us58wwmp 3024 13 following follow VBG cord-015306-us58wwmp 3024 14 relief relief NN cord-015306-us58wwmp 3024 15 of of IN cord-015306-us58wwmp 3024 16 obstruction obstruction NN cord-015306-us58wwmp 3024 17 . . . cord-015306-us58wwmp 3025 1 Supportive supportive JJ cord-015306-us58wwmp 3025 2 management management NN cord-015306-us58wwmp 3025 3 sufficed suffice VBD cord-015306-us58wwmp 3025 4 in in IN cord-015306-us58wwmp 3025 5 23 23 CD cord-015306-us58wwmp 3025 6 ( ( -LRB- cord-015306-us58wwmp 3025 7 60 60 CD cord-015306-us58wwmp 3025 8 % % NN cord-015306-us58wwmp 3025 9 ) ) -RRB- cord-015306-us58wwmp 3025 10 cases case NNS cord-015306-us58wwmp 3025 11 and and CC cord-015306-us58wwmp 3025 12 15 15 CD cord-015306-us58wwmp 3025 13 ( ( -LRB- cord-015306-us58wwmp 3025 14 37.5 37.5 CD cord-015306-us58wwmp 3025 15 % % NN cord-015306-us58wwmp 3025 16 ) ) -RRB- cord-015306-us58wwmp 3025 17 received receive VBD cord-015306-us58wwmp 3025 18 renal renal JJ cord-015306-us58wwmp 3025 19 replacement replacement NN cord-015306-us58wwmp 3025 20 therapy therapy NN cord-015306-us58wwmp 3025 21 ( ( -LRB- cord-015306-us58wwmp 3025 22 RRT rrt NN cord-015306-us58wwmp 3025 23 ) ) -RRB- cord-015306-us58wwmp 3025 24 ; ; : cord-015306-us58wwmp 3025 25 peritoneal peritoneal JJ cord-015306-us58wwmp 3025 26 dialysis dialysis NN cord-015306-us58wwmp 3025 27 being be VBG cord-015306-us58wwmp 3025 28 the the DT cord-015306-us58wwmp 3025 29 commonest common JJS cord-015306-us58wwmp 3025 30 mode mode NN cord-015306-us58wwmp 3025 31 . . . cord-015306-us58wwmp 3026 1 Most Most JJS cord-015306-us58wwmp 3026 2 children child NNS cord-015306-us58wwmp 3026 3 needing need VBG cord-015306-us58wwmp 3026 4 dialysis dialysis NN cord-015306-us58wwmp 3026 5 were be VBD cord-015306-us58wwmp 3026 6 oliguric oliguric JJ cord-015306-us58wwmp 3026 7 ( ( -LRB- cord-015306-us58wwmp 3026 8 14 14 CD cord-015306-us58wwmp 3026 9 ) ) -RRB- cord-015306-us58wwmp 3026 10 . . . cord-015306-us58wwmp 3027 1 At at IN cord-015306-us58wwmp 3027 2 discharge discharge NN cord-015306-us58wwmp 3027 3 there there EX cord-015306-us58wwmp 3027 4 were be VBD cord-015306-us58wwmp 3027 5 no no DT cord-015306-us58wwmp 3027 6 deaths death NNS cord-015306-us58wwmp 3027 7 , , , cord-015306-us58wwmp 3027 8 5 5 CD cord-015306-us58wwmp 3027 9 patients patient NNS cord-015306-us58wwmp 3027 10 showed show VBD cord-015306-us58wwmp 3027 11 complete complete JJ cord-015306-us58wwmp 3027 12 recovery recovery NN cord-015306-us58wwmp 3027 13 of of IN cord-015306-us58wwmp 3027 14 renal renal JJ cord-015306-us58wwmp 3027 15 function function NN cord-015306-us58wwmp 3027 16 , , , cord-015306-us58wwmp 3027 17 one one CD cord-015306-us58wwmp 3027 18 was be VBD cord-015306-us58wwmp 3027 19 dialysis dialysis NN cord-015306-us58wwmp 3027 20 dependant dependant JJ cord-015306-us58wwmp 3027 21 and and CC cord-015306-us58wwmp 3027 22 renal renal JJ cord-015306-us58wwmp 3027 23 function function NN cord-015306-us58wwmp 3027 24 was be VBD cord-015306-us58wwmp 3027 25 improving improve VBG cord-015306-us58wwmp 3027 26 in in IN cord-015306-us58wwmp 3027 27 the the DT cord-015306-us58wwmp 3027 28 rest rest NN cord-015306-us58wwmp 3027 29 . . . cord-015306-us58wwmp 3028 1 At at IN cord-015306-us58wwmp 3028 2 3 3 CD cord-015306-us58wwmp 3028 3 months month NNS cord-015306-us58wwmp 3028 4 we -PRON- PRP cord-015306-us58wwmp 3028 5 found find VBD cord-015306-us58wwmp 3028 6 normal normal JJ cord-015306-us58wwmp 3028 7 renal renal JJ cord-015306-us58wwmp 3028 8 function function NN cord-015306-us58wwmp 3028 9 in in IN cord-015306-us58wwmp 3028 10 26 26 CD cord-015306-us58wwmp 3028 11 ( ( -LRB- cord-015306-us58wwmp 3028 12 68 68 CD cord-015306-us58wwmp 3028 13 % % NN cord-015306-us58wwmp 3028 14 ) ) -RRB- cord-015306-us58wwmp 3028 15 children child NNS cord-015306-us58wwmp 3028 16 and and CC cord-015306-us58wwmp 3028 17 chronic chronic JJ cord-015306-us58wwmp 3028 18 kidney kidney NN cord-015306-us58wwmp 3028 19 disease disease NN cord-015306-us58wwmp 3028 20 ( ( -LRB- cord-015306-us58wwmp 3028 21 CKD CKD NNP cord-015306-us58wwmp 3028 22 ) ) -RRB- cord-015306-us58wwmp 3028 23 stage stage NN cord-015306-us58wwmp 3028 24 II II NNP cord-015306-us58wwmp 3028 25 in in IN cord-015306-us58wwmp 3028 26 7 7 CD cord-015306-us58wwmp 3028 27 ( ( -LRB- cord-015306-us58wwmp 3028 28 18 18 CD cord-015306-us58wwmp 3028 29 % % NN cord-015306-us58wwmp 3028 30 ) ) -RRB- cord-015306-us58wwmp 3028 31 and and CC cord-015306-us58wwmp 3028 32 CKD CKD NNP cord-015306-us58wwmp 3028 33 stage stage NN cord-015306-us58wwmp 3028 34 III III NNP cord-015306-us58wwmp 3028 35 in in IN cord-015306-us58wwmp 3028 36 4 4 CD cord-015306-us58wwmp 3028 37 . . . cord-015306-us58wwmp 3029 1 The the DT cord-015306-us58wwmp 3029 2 dialysis dialysis NN cord-015306-us58wwmp 3029 3 dependent dependent JJ cord-015306-us58wwmp 3029 4 child child NN cord-015306-us58wwmp 3029 5 underwent undergo VBD cord-015306-us58wwmp 3029 6 renal renal JJ cord-015306-us58wwmp 3029 7 transplantation transplantation NN cord-015306-us58wwmp 3029 8 . . . cord-015306-us58wwmp 3030 1 Based base VBN cord-015306-us58wwmp 3030 2 on on IN cord-015306-us58wwmp 3030 3 the the DT cord-015306-us58wwmp 3030 4 data datum NNS cord-015306-us58wwmp 3030 5 from from IN cord-015306-us58wwmp 3030 6 12 12 CD cord-015306-us58wwmp 3030 7 patients patient NNS cord-015306-us58wwmp 3030 8 currently currently RB cord-015306-us58wwmp 3030 9 under under IN cord-015306-us58wwmp 3030 10 follow follow NN cord-015306-us58wwmp 3030 11 up up RP cord-015306-us58wwmp 3030 12 ( ( -LRB- cord-015306-us58wwmp 3030 13 for for IN cord-015306-us58wwmp 3030 14 12 12 CD cord-015306-us58wwmp 3030 15 - - SYM cord-015306-us58wwmp 3030 16 62 62 CD cord-015306-us58wwmp 3030 17 months month NNS cord-015306-us58wwmp 3030 18 , , , cord-015306-us58wwmp 3030 19 mean mean VBP cord-015306-us58wwmp 3030 20 41 41 CD cord-015306-us58wwmp 3030 21 months month NNS cord-015306-us58wwmp 3030 22 ) ) -RRB- cord-015306-us58wwmp 3030 23 , , , cord-015306-us58wwmp 3030 24 32 32 CD cord-015306-us58wwmp 3030 25 ( ( -LRB- cord-015306-us58wwmp 3030 26 84 84 CD cord-015306-us58wwmp 3030 27 % % NN cord-015306-us58wwmp 3030 28 ) ) -RRB- cord-015306-us58wwmp 3030 29 children child NNS cord-015306-us58wwmp 3030 30 have have VBP cord-015306-us58wwmp 3030 31 recovered recover VBN cord-015306-us58wwmp 3030 32 completely completely RB cord-015306-us58wwmp 3030 33 and and CC cord-015306-us58wwmp 3030 34 5 5 CD cord-015306-us58wwmp 3030 35 have have VBP cord-015306-us58wwmp 3030 36 developed develop VBN cord-015306-us58wwmp 3030 37 CKD CKD NNP cord-015306-us58wwmp 3030 38 ; ; : cord-015306-us58wwmp 3030 39 stage stage NN cord-015306-us58wwmp 3030 40 I -PRON- PRP cord-015306-us58wwmp 3030 41 in in IN cord-015306-us58wwmp 3030 42 2 2 CD cord-015306-us58wwmp 3030 43 and and CC cord-015306-us58wwmp 3030 44 stage stage NN cord-015306-us58wwmp 3030 45 II II NNP cord-015306-us58wwmp 3030 46 in in IN cord-015306-us58wwmp 3030 47 3 3 CD cord-015306-us58wwmp 3030 48 . . . cord-015306-us58wwmp 3031 1 Conclusion conclusion NN cord-015306-us58wwmp 3031 2 : : : cord-015306-us58wwmp 3032 1 Prognosis prognosis NN cord-015306-us58wwmp 3032 2 following follow VBG cord-015306-us58wwmp 3032 3 AKI AKI NNP cord-015306-us58wwmp 3032 4 was be VBD cord-015306-us58wwmp 3032 5 excellent excellent JJ cord-015306-us58wwmp 3032 6 in in IN cord-015306-us58wwmp 3032 7 our -PRON- PRP$ cord-015306-us58wwmp 3032 8 patients patient NNS cord-015306-us58wwmp 3032 9 , , , cord-015306-us58wwmp 3032 10 probably probably RB cord-015306-us58wwmp 3032 11 because because IN cord-015306-us58wwmp 3032 12 of of IN cord-015306-us58wwmp 3032 13 lack lack NN cord-015306-us58wwmp 3032 14 of of IN cord-015306-us58wwmp 3032 15 multiorgan multiorgan NNP cord-015306-us58wwmp 3032 16 dysfunction dysfunction NN cord-015306-us58wwmp 3032 17 . . . cord-015306-us58wwmp 3033 1 HUS HUS NNP cord-015306-us58wwmp 3033 2 was be VBD cord-015306-us58wwmp 3033 3 the the DT cord-015306-us58wwmp 3033 4 commonest common JJS cord-015306-us58wwmp 3033 5 cause cause NN cord-015306-us58wwmp 3033 6 and and CC cord-015306-us58wwmp 3033 7 urgent urgent JJ cord-015306-us58wwmp 3033 8 renal renal JJ cord-015306-us58wwmp 3033 9 imaging imaging NN cord-015306-us58wwmp 3033 10 needed need VBN cord-015306-us58wwmp 3033 11 when when WRB cord-015306-us58wwmp 3033 12 obstruction obstruction NN cord-015306-us58wwmp 3033 13 is be VBZ cord-015306-us58wwmp 3033 14 suspected suspect VBN cord-015306-us58wwmp 3033 15 . . . cord-015306-us58wwmp 3034 1 Oliguric Oliguric NNP cord-015306-us58wwmp 3034 2 patients patient NNS cord-015306-us58wwmp 3034 3 are be VBP cord-015306-us58wwmp 3034 4 more more RBR cord-015306-us58wwmp 3034 5 likely likely JJ cord-015306-us58wwmp 3034 6 to to TO cord-015306-us58wwmp 3034 7 require require VB cord-015306-us58wwmp 3034 8 dialysis dialysis NN cord-015306-us58wwmp 3034 9 and and CC cord-015306-us58wwmp 3034 10 need need VB cord-015306-us58wwmp 3034 11 early early JJ cord-015306-us58wwmp 3034 12 referral referral NN cord-015306-us58wwmp 3034 13 to to IN cord-015306-us58wwmp 3034 14 the the DT cord-015306-us58wwmp 3034 15 regional regional JJ cord-015306-us58wwmp 3034 16 unit unit NN cord-015306-us58wwmp 3034 17 . . . cord-015306-us58wwmp 3035 1 All all DT cord-015306-us58wwmp 3035 2 cases case NNS cord-015306-us58wwmp 3035 3 should should MD cord-015306-us58wwmp 3035 4 have have VB cord-015306-us58wwmp 3035 5 long long JJ cord-015306-us58wwmp 3035 6 - - HYPH cord-015306-us58wwmp 3035 7 term term NN cord-015306-us58wwmp 3035 8 follow follow VB cord-015306-us58wwmp 3035 9 up up RP cord-015306-us58wwmp 3035 10 to to TO cord-015306-us58wwmp 3035 11 ensure ensure VB cord-015306-us58wwmp 3035 12 renal renal JJ cord-015306-us58wwmp 3035 13 recovery recovery NN cord-015306-us58wwmp 3035 14 and and CC cord-015306-us58wwmp 3035 15 detect detect VB cord-015306-us58wwmp 3035 16 delayed delay VBN cord-015306-us58wwmp 3035 17 complications complication NNS cord-015306-us58wwmp 3035 18 . . . cord-015306-us58wwmp 3036 1 Clinical clinical JJ cord-015306-us58wwmp 3036 2 course course NN cord-015306-us58wwmp 3036 3 and and CC cord-015306-us58wwmp 3036 4 outcome outcome NN cord-015306-us58wwmp 3036 5 of of IN cord-015306-us58wwmp 3036 6 Acute acute JJ cord-015306-us58wwmp 3036 7 kidney kidney NN cord-015306-us58wwmp 3036 8 injury injury NN cord-015306-us58wwmp 3036 9 ( ( -LRB- cord-015306-us58wwmp 3036 10 AKI AKI NNP cord-015306-us58wwmp 3036 11 ) ) -RRB- cord-015306-us58wwmp 3036 12 due due IN cord-015306-us58wwmp 3036 13 to to IN cord-015306-us58wwmp 3036 14 childhood childhood NN cord-015306-us58wwmp 3036 15 Haemolytic Haemolytic NNP cord-015306-us58wwmp 3036 16 Uremic Uremic NNP cord-015306-us58wwmp 3036 17 syndrome syndrome NN cord-015306-us58wwmp 3036 18 ( ( -LRB- cord-015306-us58wwmp 3036 19 HUS HUS NNP cord-015306-us58wwmp 3036 20 ) ) -RRB- cord-015306-us58wwmp 3036 21 : : : cord-015306-us58wwmp 3036 22 A a DT cord-015306-us58wwmp 3036 23 single single JJ cord-015306-us58wwmp 3036 24 centre centre NN cord-015306-us58wwmp 3036 25 experience experience NN cord-015306-us58wwmp 3036 26 Shivaram Shivaram NNP cord-015306-us58wwmp 3036 27 Hegde Hegde NNP cord-015306-us58wwmp 3036 28 , , , cord-015306-us58wwmp 3036 29 Sabina Sabina NNP cord-015306-us58wwmp 3036 30 Pahari Pahari NNP cord-015306-us58wwmp 3036 31 Paediatric Paediatric NNP cord-015306-us58wwmp 3036 32 nephrology nephrology NN cord-015306-us58wwmp 3036 33 , , , cord-015306-us58wwmp 3036 34 University University NNP cord-015306-us58wwmp 3036 35 Hospital Hospital NNP cord-015306-us58wwmp 3036 36 of of IN cord-015306-us58wwmp 3036 37 Wales Wales NNP cord-015306-us58wwmp 3036 38 , , , cord-015306-us58wwmp 3036 39 Cardiff Cardiff NNP cord-015306-us58wwmp 3036 40 , , , cord-015306-us58wwmp 3037 1 UK UK NNP cord-015306-us58wwmp 3037 2 Objective Objective NNP cord-015306-us58wwmp 3037 3 : : : cord-015306-us58wwmp 3037 4 Clinical clinical JJ cord-015306-us58wwmp 3037 5 data datum NNS cord-015306-us58wwmp 3037 6 , , , cord-015306-us58wwmp 3037 7 along along IN cord-015306-us58wwmp 3037 8 with with IN cord-015306-us58wwmp 3037 9 the the DT cord-015306-us58wwmp 3037 10 management management NN cord-015306-us58wwmp 3037 11 and and CC cord-015306-us58wwmp 3037 12 outcome outcome NN cord-015306-us58wwmp 3037 13 of of IN cord-015306-us58wwmp 3037 14 15 15 CD cord-015306-us58wwmp 3037 15 children child NNS cord-015306-us58wwmp 3037 16 with with IN cord-015306-us58wwmp 3037 17 AKI AKI NNP cord-015306-us58wwmp 3037 18 due due JJ cord-015306-us58wwmp 3037 19 to to IN cord-015306-us58wwmp 3037 20 HUS HUS NNP cord-015306-us58wwmp 3037 21 , , , cord-015306-us58wwmp 3037 22 caused cause VBN cord-015306-us58wwmp 3037 23 by by IN cord-015306-us58wwmp 3037 24 Shigatoxin Shigatoxin NNP cord-015306-us58wwmp 3037 25 - - HYPH cord-015306-us58wwmp 3037 26 producing produce VBG cord-015306-us58wwmp 3037 27 Ecoli Ecoli NNP cord-015306-us58wwmp 3037 28 ( ( -LRB- cord-015306-us58wwmp 3037 29 Stx Stx NNP cord-015306-us58wwmp 3037 30 - - HYPH cord-015306-us58wwmp 3037 31 HUS HUS NNP cord-015306-us58wwmp 3037 32 ) ) -RRB- cord-015306-us58wwmp 3037 33 are be VBP cord-015306-us58wwmp 3037 34 described describe VBN cord-015306-us58wwmp 3037 35 . . . cord-015306-us58wwmp 3038 1 Method method NN cord-015306-us58wwmp 3038 2 : : : cord-015306-us58wwmp 3038 3 We -PRON- PRP cord-015306-us58wwmp 3038 4 analysed analyse VBD cord-015306-us58wwmp 3038 5 the the DT cord-015306-us58wwmp 3038 6 data datum NNS cord-015306-us58wwmp 3038 7 of of IN cord-015306-us58wwmp 3038 8 children child NNS cord-015306-us58wwmp 3038 9 with with IN cord-015306-us58wwmp 3038 10 Stx Stx NNP cord-015306-us58wwmp 3038 11 - - HYPH cord-015306-us58wwmp 3038 12 HUS HUS NNP cord-015306-us58wwmp 3038 13 induced induce VBN cord-015306-us58wwmp 3038 14 AKI AKI NNP cord-015306-us58wwmp 3038 15 , , , cord-015306-us58wwmp 3038 16 managed manage VBN cord-015306-us58wwmp 3038 17 in in IN cord-015306-us58wwmp 3038 18 our -PRON- PRP$ cord-015306-us58wwmp 3038 19 unit unit NN cord-015306-us58wwmp 3038 20 over over IN cord-015306-us58wwmp 3038 21 the the DT cord-015306-us58wwmp 3038 22 last last JJ cord-015306-us58wwmp 3038 23 5 5 CD cord-015306-us58wwmp 3038 24 years year NNS cord-015306-us58wwmp 3038 25 . . . cord-015306-us58wwmp 3039 1 Outcomes outcome NNS cord-015306-us58wwmp 3039 2 noted note VBD cord-015306-us58wwmp 3039 3 as as IN cord-015306-us58wwmp 3039 4 complete complete JJ cord-015306-us58wwmp 3039 5 recovery recovery NN cord-015306-us58wwmp 3039 6 , , , cord-015306-us58wwmp 3039 7 residual residual JJ cord-015306-us58wwmp 3039 8 renal renal JJ cord-015306-us58wwmp 3039 9 injury injury NN cord-015306-us58wwmp 3039 10 , , , cord-015306-us58wwmp 3039 11 dialysis dialysis NN cord-015306-us58wwmp 3039 12 dependency dependency NN cord-015306-us58wwmp 3039 13 or or CC cord-015306-us58wwmp 3039 14 death death NN cord-015306-us58wwmp 3039 15 . . . cord-015306-us58wwmp 3040 1 All all DT cord-015306-us58wwmp 3040 2 patients patient NNS cord-015306-us58wwmp 3040 3 were be VBD cord-015306-us58wwmp 3040 4 followed follow VBN cord-015306-us58wwmp 3040 5 up up RP cord-015306-us58wwmp 3040 6 at at IN cord-015306-us58wwmp 3040 7 least least JJS cord-015306-us58wwmp 3040 8 for for IN cord-015306-us58wwmp 3040 9 a a DT cord-015306-us58wwmp 3040 10 year year NN cord-015306-us58wwmp 3040 11 and and CC cord-015306-us58wwmp 3040 12 further further JJ cord-015306-us58wwmp 3040 13 monitoring monitoring NN cord-015306-us58wwmp 3040 14 continued continue VBD cord-015306-us58wwmp 3040 15 until until IN cord-015306-us58wwmp 3040 16 their -PRON- PRP$ cord-015306-us58wwmp 3040 17 renal renal JJ cord-015306-us58wwmp 3040 18 function function NN cord-015306-us58wwmp 3040 19 normalised normalise VBN cord-015306-us58wwmp 3040 20 and and CC cord-015306-us58wwmp 3040 21 any any DT cord-015306-us58wwmp 3040 22 proteinuria proteinuria NN cord-015306-us58wwmp 3040 23 or or CC cord-015306-us58wwmp 3040 24 hypertension hypertension NN cord-015306-us58wwmp 3040 25 resolved resolve VBN cord-015306-us58wwmp 3040 26 . . . cord-015306-us58wwmp 3041 1 Methods method NNS cord-015306-us58wwmp 3041 2 and and CC cord-015306-us58wwmp 3041 3 Results result NNS cord-015306-us58wwmp 3041 4 : : : cord-015306-us58wwmp 3041 5 Stx Stx NNP cord-015306-us58wwmp 3041 6 - - HYPH cord-015306-us58wwmp 3041 7 HUS HUS NNP cord-015306-us58wwmp 3041 8 was be VBD cord-015306-us58wwmp 3041 9 the the DT cord-015306-us58wwmp 3041 10 commonest common JJS cord-015306-us58wwmp 3041 11 cause cause NN cord-015306-us58wwmp 3041 12 of of IN cord-015306-us58wwmp 3041 13 AKI AKI NNP cord-015306-us58wwmp 3041 14 in in IN cord-015306-us58wwmp 3041 15 our -PRON- PRP$ cord-015306-us58wwmp 3041 16 unit unit NN cord-015306-us58wwmp 3041 17 , , , cord-015306-us58wwmp 3041 18 accounting account VBG cord-015306-us58wwmp 3041 19 for for IN cord-015306-us58wwmp 3041 20 15 15 CD cord-015306-us58wwmp 3041 21 of of IN cord-015306-us58wwmp 3041 22 the the DT cord-015306-us58wwmp 3041 23 total total JJ cord-015306-us58wwmp 3041 24 38 38 CD cord-015306-us58wwmp 3041 25 cases case NNS cord-015306-us58wwmp 3041 26 ( ( -LRB- cord-015306-us58wwmp 3041 27 39.5 39.5 CD cord-015306-us58wwmp 3041 28 % % NN cord-015306-us58wwmp 3041 29 ) ) -RRB- cord-015306-us58wwmp 3041 30 treated treat VBN cord-015306-us58wwmp 3041 31 for for IN cord-015306-us58wwmp 3041 32 AKI AKI NNP cord-015306-us58wwmp 3041 33 during during IN cord-015306-us58wwmp 3041 34 this this DT cord-015306-us58wwmp 3041 35 period period NN cord-015306-us58wwmp 3041 36 . . . cord-015306-us58wwmp 3042 1 11 11 CD cord-015306-us58wwmp 3042 2 patients patient NNS cord-015306-us58wwmp 3042 3 were be VBD cord-015306-us58wwmp 3042 4 less less JJR cord-015306-us58wwmp 3042 5 than than IN cord-015306-us58wwmp 3042 6 10 10 CD cord-015306-us58wwmp 3042 7 years year NNS cord-015306-us58wwmp 3042 8 of of IN cord-015306-us58wwmp 3042 9 age age NN cord-015306-us58wwmp 3042 10 . . . cord-015306-us58wwmp 3043 1 All all DT cord-015306-us58wwmp 3043 2 children child NNS cord-015306-us58wwmp 3043 3 presented present VBN cord-015306-us58wwmp 3043 4 with with IN cord-015306-us58wwmp 3043 5 blood blood NN cord-015306-us58wwmp 3043 6 in in IN cord-015306-us58wwmp 3043 7 stool stool NN cord-015306-us58wwmp 3043 8 and and CC cord-015306-us58wwmp 3043 9 11 11 CD cord-015306-us58wwmp 3043 10 with with IN cord-015306-us58wwmp 3043 11 oligoanuria oligoanuria NNP cord-015306-us58wwmp 3043 12 . . . cord-015306-us58wwmp 3044 1 All all DT cord-015306-us58wwmp 3044 2 showed show VBD cord-015306-us58wwmp 3044 3 microangiopathic microangiopathic JJ cord-015306-us58wwmp 3044 4 haemolytic haemolytic JJ cord-015306-us58wwmp 3044 5 anaemia anaemia NN cord-015306-us58wwmp 3044 6 and and CC cord-015306-us58wwmp 3044 7 thrombocytopenia thrombocytopenia NN cord-015306-us58wwmp 3044 8 . . . cord-015306-us58wwmp 3045 1 Positive positive JJ cord-015306-us58wwmp 3045 2 stool stool NN cord-015306-us58wwmp 3045 3 cultures culture NNS cord-015306-us58wwmp 3045 4 ( ( -LRB- cord-015306-us58wwmp 3045 5 for for IN cord-015306-us58wwmp 3045 6 Ecoli Ecoli NNP cord-015306-us58wwmp 3045 7 0157 0157 CD cord-015306-us58wwmp 3045 8 ) ) -RRB- cord-015306-us58wwmp 3045 9 were be VBD cord-015306-us58wwmp 3045 10 obtained obtain VBN cord-015306-us58wwmp 3045 11 in in IN cord-015306-us58wwmp 3045 12 11 11 CD cord-015306-us58wwmp 3045 13 and and CC cord-015306-us58wwmp 3045 14 4 4 CD cord-015306-us58wwmp 3045 15 had have VBD cord-015306-us58wwmp 3045 16 Ecoli Ecoli NNP cord-015306-us58wwmp 3045 17 0157 0157 CD cord-015306-us58wwmp 3045 18 lipopolysaccharide lipopolysaccharide NN cord-015306-us58wwmp 3045 19 serum serum NN cord-015306-us58wwmp 3045 20 antibodies antibody NNS cord-015306-us58wwmp 3045 21 . . . cord-015306-us58wwmp 3046 1 10 10 CD cord-015306-us58wwmp 3046 2 patients patient NNS cord-015306-us58wwmp 3046 3 required require VBD cord-015306-us58wwmp 3046 4 dialysis dialysis NN cord-015306-us58wwmp 3046 5 ( ( -LRB- cord-015306-us58wwmp 3046 6 peritoneal peritoneal JJ cord-015306-us58wwmp 3046 7 dialysis dialysis NN cord-015306-us58wwmp 3046 8 in in IN cord-015306-us58wwmp 3046 9 7 7 CD cord-015306-us58wwmp 3046 10 , , , cord-015306-us58wwmp 3046 11 haemodialysis haemodialysis NNP cord-015306-us58wwmp 3046 12 in in IN cord-015306-us58wwmp 3046 13 1 1 CD cord-015306-us58wwmp 3046 14 and and CC cord-015306-us58wwmp 3046 15 both both DT cord-015306-us58wwmp 3046 16 modes mode NNS cord-015306-us58wwmp 3046 17 in in IN cord-015306-us58wwmp 3046 18 2 2 CD cord-015306-us58wwmp 3046 19 ) ) -RRB- cord-015306-us58wwmp 3046 20 and and CC cord-015306-us58wwmp 3047 1 one one CD cord-015306-us58wwmp 3047 2 child child NN cord-015306-us58wwmp 3047 3 needed need VBD cord-015306-us58wwmp 3047 4 plasma plasma NN cord-015306-us58wwmp 3047 5 exchange exchange NN cord-015306-us58wwmp 3047 6 . . . cord-015306-us58wwmp 3048 1 The the DT cord-015306-us58wwmp 3048 2 remaining remain VBG cord-015306-us58wwmp 3048 3 responded respond VBD cord-015306-us58wwmp 3048 4 to to IN cord-015306-us58wwmp 3048 5 supportive supportive JJ cord-015306-us58wwmp 3048 6 management management NN cord-015306-us58wwmp 3048 7 . . . cord-015306-us58wwmp 3049 1 Morbidities morbidity NNS cord-015306-us58wwmp 3049 2 encountered encounter VBD cord-015306-us58wwmp 3049 3 included include VBD cord-015306-us58wwmp 3049 4 bowel bowel NN cord-015306-us58wwmp 3049 5 perforation perforation NN cord-015306-us58wwmp 3049 6 ( ( -LRB- cord-015306-us58wwmp 3049 7 1 1 CD cord-015306-us58wwmp 3049 8 ) ) -RRB- cord-015306-us58wwmp 3049 9 , , , cord-015306-us58wwmp 3049 10 hypertension hypertension NN cord-015306-us58wwmp 3049 11 ( ( -LRB- cord-015306-us58wwmp 3049 12 2 2 CD cord-015306-us58wwmp 3049 13 ) ) -RRB- cord-015306-us58wwmp 3049 14 , , , cord-015306-us58wwmp 3049 15 seizures seizure NNS cord-015306-us58wwmp 3049 16 ( ( -LRB- cord-015306-us58wwmp 3049 17 2 2 CD cord-015306-us58wwmp 3049 18 ) ) -RRB- cord-015306-us58wwmp 3049 19 and and CC cord-015306-us58wwmp 3049 20 diabetes diabetes NN cord-015306-us58wwmp 3049 21 mellitus mellitus NN cord-015306-us58wwmp 3049 22 ( ( -LRB- cord-015306-us58wwmp 3049 23 1 1 CD cord-015306-us58wwmp 3049 24 ) ) -RRB- cord-015306-us58wwmp 3049 25 and and CC cord-015306-us58wwmp 3049 26 three three CD cord-015306-us58wwmp 3049 27 of of IN cord-015306-us58wwmp 3049 28 these these DT cord-015306-us58wwmp 3049 29 children child NNS cord-015306-us58wwmp 3049 30 needed need VBD cord-015306-us58wwmp 3049 31 intensive intensive JJ cord-015306-us58wwmp 3049 32 care care NN cord-015306-us58wwmp 3049 33 management management NN cord-015306-us58wwmp 3049 34 . . . cord-015306-us58wwmp 3050 1 At at IN cord-015306-us58wwmp 3050 2 discharge discharge NN cord-015306-us58wwmp 3050 3 there there EX cord-015306-us58wwmp 3050 4 were be VBD cord-015306-us58wwmp 3050 5 no no DT cord-015306-us58wwmp 3050 6 deaths death NNS cord-015306-us58wwmp 3050 7 , , , cord-015306-us58wwmp 3050 8 none none NN cord-015306-us58wwmp 3050 9 with with IN cord-015306-us58wwmp 3050 10 dialysis dialysis NN cord-015306-us58wwmp 3050 11 dependency dependency NN cord-015306-us58wwmp 3050 12 or or CC cord-015306-us58wwmp 3050 13 complete complete JJ cord-015306-us58wwmp 3050 14 renal renal JJ cord-015306-us58wwmp 3050 15 recovery recovery NN cord-015306-us58wwmp 3050 16 but but CC cord-015306-us58wwmp 3050 17 all all DT cord-015306-us58wwmp 3050 18 showing show VBG cord-015306-us58wwmp 3050 19 improving improve VBG cord-015306-us58wwmp 3050 20 renal renal JJ cord-015306-us58wwmp 3050 21 function function NN cord-015306-us58wwmp 3050 22 . . . cord-015306-us58wwmp 3051 1 At at IN cord-015306-us58wwmp 3051 2 3 3 CD cord-015306-us58wwmp 3051 3 months month NNS cord-015306-us58wwmp 3051 4 we -PRON- PRP cord-015306-us58wwmp 3051 5 found find VBD cord-015306-us58wwmp 3051 6 normal normal JJ cord-015306-us58wwmp 3051 7 renal renal JJ cord-015306-us58wwmp 3051 8 function function NN cord-015306-us58wwmp 3051 9 in in IN cord-015306-us58wwmp 3051 10 12 12 CD cord-015306-us58wwmp 3051 11 ( ( -LRB- cord-015306-us58wwmp 3051 12 80 80 CD cord-015306-us58wwmp 3051 13 % % NN cord-015306-us58wwmp 3051 14 ) ) -RRB- cord-015306-us58wwmp 3051 15 and and CC cord-015306-us58wwmp 3051 16 chronic chronic JJ cord-015306-us58wwmp 3051 17 kidney kidney NN cord-015306-us58wwmp 3051 18 disease disease NN cord-015306-us58wwmp 3051 19 ( ( -LRB- cord-015306-us58wwmp 3051 20 CKD CKD NNP cord-015306-us58wwmp 3051 21 ) ) -RRB- cord-015306-us58wwmp 3051 22 stage stage NN cord-015306-us58wwmp 3051 23 II II NNP cord-015306-us58wwmp 3051 24 in in IN cord-015306-us58wwmp 3051 25 2 2 CD cord-015306-us58wwmp 3051 26 and and CC cord-015306-us58wwmp 3051 27 CKD CKD NNP cord-015306-us58wwmp 3051 28 stage stage NN cord-015306-us58wwmp 3051 29 III III NNP cord-015306-us58wwmp 3051 30 in in IN cord-015306-us58wwmp 3051 31 1 1 CD cord-015306-us58wwmp 3051 32 . . . cord-015306-us58wwmp 3052 1 A a DT cord-015306-us58wwmp 3052 2 13 13 CD cord-015306-us58wwmp 3052 3 year year NN cord-015306-us58wwmp 3052 4 old old JJ cord-015306-us58wwmp 3052 5 girl girl NN cord-015306-us58wwmp 3052 6 with with IN cord-015306-us58wwmp 3052 7 an an DT cord-015306-us58wwmp 3052 8 unknown unknown JJ cord-015306-us58wwmp 3052 9 myopathy myopathy NN cord-015306-us58wwmp 3052 10 presented present VBN cord-015306-us58wwmp 3052 11 for for IN cord-015306-us58wwmp 3052 12 the the DT cord-015306-us58wwmp 3052 13 third third JJ cord-015306-us58wwmp 3052 14 time time NN cord-015306-us58wwmp 3052 15 with with IN cord-015306-us58wwmp 3052 16 clinical clinical JJ cord-015306-us58wwmp 3052 17 and and CC cord-015306-us58wwmp 3052 18 laboratory laboratory NN cord-015306-us58wwmp 3052 19 features feature NNS cord-015306-us58wwmp 3052 20 of of IN cord-015306-us58wwmp 3052 21 rhabdomyolysis rhabdomyolysis NN cord-015306-us58wwmp 3052 22 . . . cord-015306-us58wwmp 3053 1 On on IN cord-015306-us58wwmp 3053 2 day day NN cord-015306-us58wwmp 3053 3 two two CD cord-015306-us58wwmp 3053 4 of of IN cord-015306-us58wwmp 3053 5 admission admission NN cord-015306-us58wwmp 3053 6 , , , cord-015306-us58wwmp 3053 7 her -PRON- PRP$ cord-015306-us58wwmp 3053 8 renal renal JJ cord-015306-us58wwmp 3053 9 function function NN cord-015306-us58wwmp 3053 10 deteriorated deteriorate VBD cord-015306-us58wwmp 3053 11 with with IN cord-015306-us58wwmp 3053 12 decreased decrease VBN cord-015306-us58wwmp 3053 13 urine urine NN cord-015306-us58wwmp 3053 14 output output NN cord-015306-us58wwmp 3053 15 , , , cord-015306-us58wwmp 3053 16 increasing increase VBG cord-015306-us58wwmp 3053 17 creatinine creatinine NN cord-015306-us58wwmp 3053 18 of of IN cord-015306-us58wwmp 3053 19 380 380 CD cord-015306-us58wwmp 3053 20 μmol μmol NNP cord-015306-us58wwmp 3053 21 / / SYM cord-015306-us58wwmp 3053 22 l l NNP cord-015306-us58wwmp 3053 23 and and CC cord-015306-us58wwmp 3053 24 CK CK NNP cord-015306-us58wwmp 3053 25 of of IN cord-015306-us58wwmp 3053 26 240,220 240,220 CD cord-015306-us58wwmp 3053 27 IU IU NNP cord-015306-us58wwmp 3053 28 / / SYM cord-015306-us58wwmp 3053 29 l l NN cord-015306-us58wwmp 3053 30 . . . cord-015306-us58wwmp 3054 1 She -PRON- PRP cord-015306-us58wwmp 3054 2 was be VBD cord-015306-us58wwmp 3054 3 commenced commence VBN cord-015306-us58wwmp 3054 4 on on IN cord-015306-us58wwmp 3054 5 haemodialysis haemodialysis NNP cord-015306-us58wwmp 3054 6 and and CC cord-015306-us58wwmp 3054 7 started start VBD cord-015306-us58wwmp 3054 8 on on IN cord-015306-us58wwmp 3054 9 calcium calcium NN cord-015306-us58wwmp 3054 10 supplements supplement NNS cord-015306-us58wwmp 3054 11 , , , cord-015306-us58wwmp 3054 12 as as IN cord-015306-us58wwmp 3054 13 her -PRON- PRP$ cord-015306-us58wwmp 3054 14 calcium calcium NN cord-015306-us58wwmp 3054 15 levels level NNS cord-015306-us58wwmp 3054 16 were be VBD cord-015306-us58wwmp 3054 17 1.6 1.6 CD cord-015306-us58wwmp 3054 18 mmol mmol JJ cord-015306-us58wwmp 3054 19 / / SYM cord-015306-us58wwmp 3054 20 l l NN cord-015306-us58wwmp 3054 21 . . . cord-015306-us58wwmp 3055 1 Three three CD cord-015306-us58wwmp 3055 2 week week NN cord-015306-us58wwmp 3055 3 into into IN cord-015306-us58wwmp 3055 4 her -PRON- PRP$ cord-015306-us58wwmp 3055 5 illness illness NN cord-015306-us58wwmp 3055 6 , , , cord-015306-us58wwmp 3055 7 she -PRON- PRP cord-015306-us58wwmp 3055 8 was be VBD cord-015306-us58wwmp 3055 9 symptomatic symptomatic JJ cord-015306-us58wwmp 3055 10 with with IN cord-015306-us58wwmp 3055 11 high high JJ cord-015306-us58wwmp 3055 12 blood blood NN cord-015306-us58wwmp 3055 13 pressure pressure NN cord-015306-us58wwmp 3055 14 of of IN cord-015306-us58wwmp 3055 15 170 170 CD cord-015306-us58wwmp 3055 16 mm mm NNS cord-015306-us58wwmp 3055 17 of of IN cord-015306-us58wwmp 3055 18 Hg Hg NNP cord-015306-us58wwmp 3055 19 leading lead VBG cord-015306-us58wwmp 3055 20 to to IN cord-015306-us58wwmp 3055 21 a a DT cord-015306-us58wwmp 3055 22 generalised generalised JJ cord-015306-us58wwmp 3055 23 seizure seizure NN cord-015306-us58wwmp 3055 24 . . . cord-015306-us58wwmp 3056 1 Her -PRON- PRP$ cord-015306-us58wwmp 3056 2 serum serum NN cord-015306-us58wwmp 3056 3 calcium calcium NN cord-015306-us58wwmp 3056 4 was be VBD cord-015306-us58wwmp 3056 5 4.01 4.01 CD cord-015306-us58wwmp 3056 6 mmol mmol JJ cord-015306-us58wwmp 3056 7 / / SYM cord-015306-us58wwmp 3056 8 l l NN cord-015306-us58wwmp 3056 9 . . . cord-015306-us58wwmp 3057 1 The the DT cord-015306-us58wwmp 3057 2 CT CT NNP cord-015306-us58wwmp 3057 3 brain brain NN cord-015306-us58wwmp 3057 4 did do VBD cord-015306-us58wwmp 3057 5 not not RB cord-015306-us58wwmp 3057 6 reveal reveal VB cord-015306-us58wwmp 3057 7 any any DT cord-015306-us58wwmp 3057 8 evidence evidence NN cord-015306-us58wwmp 3057 9 of of IN cord-015306-us58wwmp 3057 10 haemorrhage haemorrhage NN cord-015306-us58wwmp 3057 11 or or CC cord-015306-us58wwmp 3057 12 infarction infarction NN cord-015306-us58wwmp 3057 13 . . . cord-015306-us58wwmp 3058 1 There there EX cord-015306-us58wwmp 3058 2 were be VBD cord-015306-us58wwmp 3058 3 no no DT cord-015306-us58wwmp 3058 4 other other JJ cord-015306-us58wwmp 3058 5 trigger trigger NN cord-015306-us58wwmp 3058 6 factors factor NNS cord-015306-us58wwmp 3058 7 identified identify VBN cord-015306-us58wwmp 3058 8 for for IN cord-015306-us58wwmp 3058 9 the the DT cord-015306-us58wwmp 3058 10 seizure seizure NN cord-015306-us58wwmp 3058 11 and and CC cord-015306-us58wwmp 3058 12 the the DT cord-015306-us58wwmp 3058 13 hypertension hypertension NN cord-015306-us58wwmp 3058 14 , , , cord-015306-us58wwmp 3058 15 apart apart RB cord-015306-us58wwmp 3058 16 from from IN cord-015306-us58wwmp 3058 17 the the DT cord-015306-us58wwmp 3058 18 hypercalcaemia hypercalcaemia NN cord-015306-us58wwmp 3058 19 . . . cord-015306-us58wwmp 3059 1 The the DT cord-015306-us58wwmp 3059 2 hypercalcaemia hypercalcaemia NN cord-015306-us58wwmp 3059 3 was be VBD cord-015306-us58wwmp 3059 4 managed manage VBN cord-015306-us58wwmp 3059 5 with with IN cord-015306-us58wwmp 3059 6 low low JJ cord-015306-us58wwmp 3059 7 calcium calcium NN cord-015306-us58wwmp 3059 8 dialysate dialysate NN cord-015306-us58wwmp 3059 9 , , , cord-015306-us58wwmp 3059 10 calcitonin calcitonin NN cord-015306-us58wwmp 3059 11 and and CC cord-015306-us58wwmp 3059 12 Sevalamer Sevalamer NNP cord-015306-us58wwmp 3059 13 . . . cord-015306-us58wwmp 3060 1 Despite despite IN cord-015306-us58wwmp 3060 2 the the DT cord-015306-us58wwmp 3060 3 above above JJ cord-015306-us58wwmp 3060 4 treatments treatment NNS cord-015306-us58wwmp 3060 5 , , , cord-015306-us58wwmp 3060 6 she -PRON- PRP cord-015306-us58wwmp 3060 7 continued continue VBD cord-015306-us58wwmp 3060 8 to to TO cord-015306-us58wwmp 3060 9 be be VB cord-015306-us58wwmp 3060 10 hypercalcemic hypercalcemic NNP cord-015306-us58wwmp 3060 11 and and CC cord-015306-us58wwmp 3060 12 developed develop VBD cord-015306-us58wwmp 3060 13 erythematous erythematous JJ cord-015306-us58wwmp 3060 14 palms palm NNS cord-015306-us58wwmp 3060 15 and and CC cord-015306-us58wwmp 3060 16 soles sol NNS cord-015306-us58wwmp 3060 17 and and CC cord-015306-us58wwmp 3060 18 an an DT cord-015306-us58wwmp 3060 19 injected inject VBN cord-015306-us58wwmp 3060 20 conjunctiva conjunctiva NN cord-015306-us58wwmp 3060 21 . . . cord-015306-us58wwmp 3061 1 In in IN cord-015306-us58wwmp 3061 2 view view NN cord-015306-us58wwmp 3061 3 of of IN cord-015306-us58wwmp 3061 4 the the DT cord-015306-us58wwmp 3061 5 refractory refractory JJ cord-015306-us58wwmp 3061 6 hypercalcaemia hypercalcaemia NN cord-015306-us58wwmp 3061 7 , , , cord-015306-us58wwmp 3061 8 She -PRON- PRP cord-015306-us58wwmp 3061 9 received receive VBD cord-015306-us58wwmp 3061 10 two two CD cord-015306-us58wwmp 3061 11 doses dose NNS cord-015306-us58wwmp 3061 12 of of IN cord-015306-us58wwmp 3061 13 intravenous intravenous JJ cord-015306-us58wwmp 3061 14 Pamidronate Pamidronate NNP cord-015306-us58wwmp 3061 15 ( ( -LRB- cord-015306-us58wwmp 3061 16 0.5 0.5 CD cord-015306-us58wwmp 3061 17 -1 -1 CD cord-015306-us58wwmp 3061 18 mg mg NNP cord-015306-us58wwmp 3061 19 / / SYM cord-015306-us58wwmp 3061 20 kg kg NNP cord-015306-us58wwmp 3061 21 ) ) -RRB- cord-015306-us58wwmp 3061 22 when when WRB cord-015306-us58wwmp 3061 23 the the DT cord-015306-us58wwmp 3061 24 creatinine creatinine NN cord-015306-us58wwmp 3061 25 was be VBD cord-015306-us58wwmp 3061 26 317 317 CD cord-015306-us58wwmp 3061 27 mmol mmol JJ cord-015306-us58wwmp 3061 28 / / SYM cord-015306-us58wwmp 3061 29 l l NN cord-015306-us58wwmp 3061 30 . . . cord-015306-us58wwmp 3062 1 Following follow VBG cord-015306-us58wwmp 3062 2 this this DT cord-015306-us58wwmp 3062 3 , , , cord-015306-us58wwmp 3062 4 her -PRON- PRP$ cord-015306-us58wwmp 3062 5 calcium calcium NN cord-015306-us58wwmp 3062 6 levels level NNS cord-015306-us58wwmp 3062 7 normalised normalise VBN cord-015306-us58wwmp 3062 8 to to IN cord-015306-us58wwmp 3062 9 2.59 2.59 CD cord-015306-us58wwmp 3062 10 mmol mmol JJ cord-015306-us58wwmp 3062 11 / / SYM cord-015306-us58wwmp 3062 12 l l NN cord-015306-us58wwmp 3062 13 . . . cord-015306-us58wwmp 3063 1 Her -PRON- PRP$ cord-015306-us58wwmp 3063 2 renal renal JJ cord-015306-us58wwmp 3063 3 function function NN cord-015306-us58wwmp 3063 4 improved improve VBD cord-015306-us58wwmp 3063 5 and and CC cord-015306-us58wwmp 3063 6 was be VBD cord-015306-us58wwmp 3063 7 discharged discharge VBN cord-015306-us58wwmp 3063 8 a a DT cord-015306-us58wwmp 3063 9 week week NN cord-015306-us58wwmp 3063 10 later later RB cord-015306-us58wwmp 3063 11 . . . cord-015306-us58wwmp 3064 1 There there EX cord-015306-us58wwmp 3064 2 was be VBD cord-015306-us58wwmp 3064 3 no no DT cord-015306-us58wwmp 3064 4 nephrocalcinosis nephrocalcinosis NN cord-015306-us58wwmp 3064 5 seen see VBN cord-015306-us58wwmp 3064 6 on on IN cord-015306-us58wwmp 3064 7 follow follow VB cord-015306-us58wwmp 3064 8 up up RP cord-015306-us58wwmp 3064 9 . . . cord-015306-us58wwmp 3065 1 Bisphosphonates Bisphosphonates NNP cord-015306-us58wwmp 3065 2 are be VBP cord-015306-us58wwmp 3065 3 used use VBN cord-015306-us58wwmp 3065 4 in in IN cord-015306-us58wwmp 3065 5 children child NNS cord-015306-us58wwmp 3065 6 with with IN cord-015306-us58wwmp 3065 7 caution caution NN cord-015306-us58wwmp 3065 8 , , , cord-015306-us58wwmp 3065 9 as as IN cord-015306-us58wwmp 3065 10 there there EX cord-015306-us58wwmp 3065 11 is be VBZ cord-015306-us58wwmp 3065 12 little little JJ cord-015306-us58wwmp 3065 13 evidence evidence NN cord-015306-us58wwmp 3065 14 on on IN cord-015306-us58wwmp 3065 15 its -PRON- PRP$ cord-015306-us58wwmp 3065 16 safety safety NN cord-015306-us58wwmp 3065 17 and and CC cord-015306-us58wwmp 3065 18 efficacy efficacy NN cord-015306-us58wwmp 3065 19 . . . cord-015306-us58wwmp 3066 1 They -PRON- PRP cord-015306-us58wwmp 3066 2 act act VBP cord-015306-us58wwmp 3066 3 by by IN cord-015306-us58wwmp 3066 4 binding bind VBG cord-015306-us58wwmp 3066 5 to to IN cord-015306-us58wwmp 3066 6 the the DT cord-015306-us58wwmp 3066 7 surface surface NN cord-015306-us58wwmp 3066 8 of of IN cord-015306-us58wwmp 3066 9 calcium calcium NN cord-015306-us58wwmp 3066 10 phosphate phosphate NN cord-015306-us58wwmp 3066 11 crystals crystal NNS cord-015306-us58wwmp 3066 12 and and CC cord-015306-us58wwmp 3066 13 inhibiting inhibit VBG cord-015306-us58wwmp 3066 14 osteoclast osteoclast JJ cord-015306-us58wwmp 3066 15 formation formation NN cord-015306-us58wwmp 3066 16 , , , cord-015306-us58wwmp 3066 17 aggregation aggregation NN cord-015306-us58wwmp 3066 18 and and CC cord-015306-us58wwmp 3066 19 dissolution dissolution NN cord-015306-us58wwmp 3066 20 . . . cord-015306-us58wwmp 3067 1 It -PRON- PRP cord-015306-us58wwmp 3067 2 is be VBZ cord-015306-us58wwmp 3067 3 nephrotoxic nephrotoxic RB cord-015306-us58wwmp 3067 4 causing cause VBG cord-015306-us58wwmp 3067 5 acute acute JJ cord-015306-us58wwmp 3067 6 tubular tubular JJ cord-015306-us58wwmp 3067 7 necrosis necrosis NN cord-015306-us58wwmp 3067 8 and and CC cord-015306-us58wwmp 3067 9 collapsing collapse VBG cord-015306-us58wwmp 3067 10 focal focal JJ cord-015306-us58wwmp 3067 11 segmental segmental JJ cord-015306-us58wwmp 3067 12 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 3067 13 . . . cord-015306-us58wwmp 3068 1 Pamidronate Pamidronate NNP cord-015306-us58wwmp 3068 2 is be VBZ cord-015306-us58wwmp 3068 3 usually usually RB cord-015306-us58wwmp 3068 4 used use VBN cord-015306-us58wwmp 3068 5 in in IN cord-015306-us58wwmp 3068 6 children child NNS cord-015306-us58wwmp 3068 7 with with IN cord-015306-us58wwmp 3068 8 chronic chronic JJ cord-015306-us58wwmp 3068 9 kidney kidney NN cord-015306-us58wwmp 3068 10 disease disease NN cord-015306-us58wwmp 3068 11 but but CC cord-015306-us58wwmp 3068 12 this this DT cord-015306-us58wwmp 3068 13 was be VBD cord-015306-us58wwmp 3068 14 the the DT cord-015306-us58wwmp 3068 15 first first JJ cord-015306-us58wwmp 3068 16 time time NN cord-015306-us58wwmp 3068 17 it -PRON- PRP cord-015306-us58wwmp 3068 18 was be VBD cord-015306-us58wwmp 3068 19 used use VBN cord-015306-us58wwmp 3068 20 in in IN cord-015306-us58wwmp 3068 21 a a DT cord-015306-us58wwmp 3068 22 child child NN cord-015306-us58wwmp 3068 23 recovering recover VBG cord-015306-us58wwmp 3068 24 from from IN cord-015306-us58wwmp 3068 25 acute acute JJ cord-015306-us58wwmp 3068 26 kidney kidney NN cord-015306-us58wwmp 3068 27 injury injury NN cord-015306-us58wwmp 3068 28 secondary secondary JJ cord-015306-us58wwmp 3068 29 to to IN cord-015306-us58wwmp 3068 30 rhabdomyolysis rhabdomyolysis NN cord-015306-us58wwmp 3068 31 . . . cord-015306-us58wwmp 3069 1 There there EX cord-015306-us58wwmp 3069 2 were be VBD cord-015306-us58wwmp 3069 3 no no DT cord-015306-us58wwmp 3069 4 complications complication NNS cord-015306-us58wwmp 3069 5 with with IN cord-015306-us58wwmp 3069 6 the the DT cord-015306-us58wwmp 3069 7 use use NN cord-015306-us58wwmp 3069 8 of of IN cord-015306-us58wwmp 3069 9 pamidronate pamidronate NN cord-015306-us58wwmp 3069 10 in in IN cord-015306-us58wwmp 3069 11 our -PRON- PRP$ cord-015306-us58wwmp 3069 12 patient patient NN cord-015306-us58wwmp 3069 13 . . . cord-015306-us58wwmp 3070 1 Chronic chronic JJ cord-015306-us58wwmp 3070 2 kidney kidney NN cord-015306-us58wwmp 3070 3 disease disease NN cord-015306-us58wwmp 3070 4 during during IN cord-015306-us58wwmp 3070 5 long long JJ cord-015306-us58wwmp 3070 6 - - HYPH cord-015306-us58wwmp 3070 7 term term NN cord-015306-us58wwmp 3070 8 follow follow NN cord-015306-us58wwmp 3070 9 - - HYPH cord-015306-us58wwmp 3070 10 up up NN cord-015306-us58wwmp 3070 11 in in IN cord-015306-us58wwmp 3070 12 children child NNS cord-015306-us58wwmp 3070 13 treated treat VBN cord-015306-us58wwmp 3070 14 with with IN cord-015306-us58wwmp 3070 15 neonatal neonatal JJ cord-015306-us58wwmp 3070 16 extracorporeal extracorporeal JJ cord-015306-us58wwmp 3070 17 membrane membrane NN cord-015306-us58wwmp 3070 18 oxygenation oxygenation NN cord-015306-us58wwmp 3070 19 : : : cord-015306-us58wwmp 3070 20 do do VBP cord-015306-us58wwmp 3070 21 we -PRON- PRP cord-015306-us58wwmp 3070 22 need need VB cord-015306-us58wwmp 3070 23 to to TO cord-015306-us58wwmp 3070 24 worry worry VB cord-015306-us58wwmp 3070 25 ? ? . cord-015306-us58wwmp 3071 1 Objective objective NN cord-015306-us58wwmp 3071 2 : : : cord-015306-us58wwmp 3072 1 Acute acute JJ cord-015306-us58wwmp 3072 2 kidney kidney NN cord-015306-us58wwmp 3072 3 injury injury NN cord-015306-us58wwmp 3072 4 ( ( -LRB- cord-015306-us58wwmp 3072 5 AKI AKI NNP cord-015306-us58wwmp 3072 6 ) ) -RRB- cord-015306-us58wwmp 3072 7 is be VBZ cord-015306-us58wwmp 3072 8 a a DT cord-015306-us58wwmp 3072 9 common common JJ cord-015306-us58wwmp 3072 10 complication complication NN cord-015306-us58wwmp 3072 11 in in IN cord-015306-us58wwmp 3072 12 children child NNS cord-015306-us58wwmp 3072 13 receiving receive VBG cord-015306-us58wwmp 3072 14 extracorporeal extracorporeal JJ cord-015306-us58wwmp 3072 15 membrane membrane NN cord-015306-us58wwmp 3072 16 oxygenation oxygenation NN cord-015306-us58wwmp 3072 17 ( ( -LRB- cord-015306-us58wwmp 3072 18 ECMO ECMO NNP cord-015306-us58wwmp 3072 19 ) ) -RRB- cord-015306-us58wwmp 3072 20 support support NN cord-015306-us58wwmp 3072 21 . . . cord-015306-us58wwmp 3073 1 As as IN cord-015306-us58wwmp 3073 2 AKI AKI NNP cord-015306-us58wwmp 3073 3 may may MD cord-015306-us58wwmp 3073 4 cause cause VB cord-015306-us58wwmp 3073 5 loss loss NN cord-015306-us58wwmp 3073 6 of of IN cord-015306-us58wwmp 3073 7 a a DT cord-015306-us58wwmp 3073 8 significant significant JJ cord-015306-us58wwmp 3073 9 number number NN cord-015306-us58wwmp 3073 10 of of IN cord-015306-us58wwmp 3073 11 functioning function VBG cord-015306-us58wwmp 3073 12 nephrons nephron NNS cord-015306-us58wwmp 3073 13 , , , cord-015306-us58wwmp 3073 14 these these DT cord-015306-us58wwmp 3073 15 children child NNS cord-015306-us58wwmp 3073 16 are be VBP cord-015306-us58wwmp 3073 17 at at IN cord-015306-us58wwmp 3073 18 risk risk NN cord-015306-us58wwmp 3073 19 of of IN cord-015306-us58wwmp 3073 20 developing develop VBG cord-015306-us58wwmp 3073 21 Chronic Chronic NNP cord-015306-us58wwmp 3073 22 Kidney Kidney NNP cord-015306-us58wwmp 3073 23 Disease Disease NNP cord-015306-us58wwmp 3073 24 ( ( -LRB- cord-015306-us58wwmp 3073 25 CKD CKD NNP cord-015306-us58wwmp 3073 26 ) ) -RRB- cord-015306-us58wwmp 3073 27 post post JJ cord-015306-us58wwmp 3073 28 - - NN cord-015306-us58wwmp 3073 29 ECMO ECMO NNP cord-015306-us58wwmp 3073 30 . . . cord-015306-us58wwmp 3074 1 Therapeutic therapeutic JJ cord-015306-us58wwmp 3074 2 interventions intervention NNS cord-015306-us58wwmp 3074 3 might may MD cord-015306-us58wwmp 3074 4 be be VB cord-015306-us58wwmp 3074 5 needed need VBN cord-015306-us58wwmp 3074 6 to to TO cord-015306-us58wwmp 3074 7 prevent prevent VB cord-015306-us58wwmp 3074 8 further further JJ cord-015306-us58wwmp 3074 9 renal renal JJ cord-015306-us58wwmp 3074 10 function function NN cord-015306-us58wwmp 3074 11 deterioration deterioration NN cord-015306-us58wwmp 3074 12 or or CC cord-015306-us58wwmp 3074 13 comorbidity comorbidity NN cord-015306-us58wwmp 3074 14 of of IN cord-015306-us58wwmp 3074 15 CKD CKD NNP cord-015306-us58wwmp 3074 16 in in IN cord-015306-us58wwmp 3074 17 these these DT cord-015306-us58wwmp 3074 18 patients patient NNS cord-015306-us58wwmp 3074 19 . . . cord-015306-us58wwmp 3075 1 The the DT cord-015306-us58wwmp 3075 2 objective objective NN cord-015306-us58wwmp 3075 3 of of IN cord-015306-us58wwmp 3075 4 our -PRON- PRP$ cord-015306-us58wwmp 3075 5 study study NN cord-015306-us58wwmp 3075 6 was be VBD cord-015306-us58wwmp 3075 7 to to TO cord-015306-us58wwmp 3075 8 determine determine VB cord-015306-us58wwmp 3075 9 the the DT cord-015306-us58wwmp 3075 10 prevalence prevalence NN cord-015306-us58wwmp 3075 11 of of IN cord-015306-us58wwmp 3075 12 CKD CKD NNP cord-015306-us58wwmp 3075 13 during during IN cord-015306-us58wwmp 3075 14 long long JJ cord-015306-us58wwmp 3075 15 - - HYPH cord-015306-us58wwmp 3075 16 term term NN cord-015306-us58wwmp 3075 17 follow follow NN cord-015306-us58wwmp 3075 18 - - HYPH cord-015306-us58wwmp 3075 19 up up NN cord-015306-us58wwmp 3075 20 ( ( -LRB- cord-015306-us58wwmp 3075 21 FUP FUP NNP cord-015306-us58wwmp 3075 22 ) ) -RRB- cord-015306-us58wwmp 3075 23 of of IN cord-015306-us58wwmp 3075 24 children child NNS cord-015306-us58wwmp 3075 25 treated treat VBN cord-015306-us58wwmp 3075 26 with with IN cord-015306-us58wwmp 3075 27 ECMO ECMO NNP cord-015306-us58wwmp 3075 28 . . . cord-015306-us58wwmp 3076 1 Methods method NNS cord-015306-us58wwmp 3076 2 : : : cord-015306-us58wwmp 3076 3 This this DT cord-015306-us58wwmp 3076 4 was be VBD cord-015306-us58wwmp 3076 5 a a DT cord-015306-us58wwmp 3076 6 cross cross JJ cord-015306-us58wwmp 3076 7 - - JJ cord-015306-us58wwmp 3076 8 sectional sectional JJ cord-015306-us58wwmp 3076 9 study study NN cord-015306-us58wwmp 3076 10 performed perform VBN cord-015306-us58wwmp 3076 11 between between IN cord-015306-us58wwmp 3076 12 2010 2010 CD cord-015306-us58wwmp 3076 13 and and CC cord-015306-us58wwmp 3076 14 2013 2013 CD cord-015306-us58wwmp 3076 15 . . . cord-015306-us58wwmp 3077 1 All all DT cord-015306-us58wwmp 3077 2 children child NNS cord-015306-us58wwmp 3077 3 previously previously RB cord-015306-us58wwmp 3077 4 treated treat VBN cord-015306-us58wwmp 3077 5 with with IN cord-015306-us58wwmp 3077 6 neonatal neonatal JJ cord-015306-us58wwmp 3077 7 ECMO ECMO NNP cord-015306-us58wwmp 3077 8 who who WP cord-015306-us58wwmp 3077 9 visited visit VBD cord-015306-us58wwmp 3077 10 our -PRON- PRP$ cord-015306-us58wwmp 3077 11 FUP FUP NNP cord-015306-us58wwmp 3077 12 clinic clinic NN cord-015306-us58wwmp 3077 13 at at IN cord-015306-us58wwmp 3077 14 the the DT cord-015306-us58wwmp 3077 15 age age NN cord-015306-us58wwmp 3077 16 of of IN cord-015306-us58wwmp 3077 17 1 1 CD cord-015306-us58wwmp 3077 18 , , , cord-015306-us58wwmp 3077 19 2 2 CD cord-015306-us58wwmp 3077 20 , , , cord-015306-us58wwmp 3077 21 5 5 CD cord-015306-us58wwmp 3077 22 , , , cord-015306-us58wwmp 3077 23 8 8 CD cord-015306-us58wwmp 3077 24 , , , cord-015306-us58wwmp 3077 25 12 12 CD cord-015306-us58wwmp 3077 26 and and CC cord-015306-us58wwmp 3077 27 18 18 CD cord-015306-us58wwmp 3077 28 years year NNS cord-015306-us58wwmp 3077 29 were be VBD cord-015306-us58wwmp 3077 30 screened screen VBN cord-015306-us58wwmp 3077 31 for for IN cord-015306-us58wwmp 3077 32 CKD CKD NNP cord-015306-us58wwmp 3077 33 . . . cord-015306-us58wwmp 3078 1 If if IN cord-015306-us58wwmp 3078 2 more more JJR cord-015306-us58wwmp 3078 3 check check NN cord-015306-us58wwmp 3078 4 - - HYPH cord-015306-us58wwmp 3078 5 ups up NNS cord-015306-us58wwmp 3078 6 were be VBD cord-015306-us58wwmp 3078 7 available available JJ cord-015306-us58wwmp 3078 8 per per IN cord-015306-us58wwmp 3078 9 patient patient NN cord-015306-us58wwmp 3078 10 , , , cord-015306-us58wwmp 3078 11 only only RB cord-015306-us58wwmp 3078 12 the the DT cord-015306-us58wwmp 3078 13 latter latter JJ cord-015306-us58wwmp 3078 14 one one NN cord-015306-us58wwmp 3078 15 was be VBD cord-015306-us58wwmp 3078 16 used use VBN cord-015306-us58wwmp 3078 17 for for IN cord-015306-us58wwmp 3078 18 the the DT cord-015306-us58wwmp 3078 19 study study NN cord-015306-us58wwmp 3078 20 . . . cord-015306-us58wwmp 3079 1 CKD CKD NNP cord-015306-us58wwmp 3079 2 screening screening NN cord-015306-us58wwmp 3079 3 included include VBD cord-015306-us58wwmp 3079 4 height height NN cord-015306-us58wwmp 3079 5 ( ( -LRB- cord-015306-us58wwmp 3079 6 Ht Ht NNP cord-015306-us58wwmp 3079 7 ) ) -RRB- cord-015306-us58wwmp 3079 8 and and CC cord-015306-us58wwmp 3079 9 blood blood NN cord-015306-us58wwmp 3079 10 pressure pressure NN cord-015306-us58wwmp 3079 11 measurements measurement NNS cord-015306-us58wwmp 3079 12 ( ( -LRB- cord-015306-us58wwmp 3079 13 BP BP NNP cord-015306-us58wwmp 3079 14 ) ) -RRB- cord-015306-us58wwmp 3079 15 , , , cord-015306-us58wwmp 3079 16 and and CC cord-015306-us58wwmp 3079 17 laboratory laboratory NN cord-015306-us58wwmp 3079 18 parameters parameter NNS cord-015306-us58wwmp 3079 19 including include VBG cord-015306-us58wwmp 3079 20 serum serum NN cord-015306-us58wwmp 3079 21 creatinine creatinine NN cord-015306-us58wwmp 3079 22 ( ( -LRB- cord-015306-us58wwmp 3079 23 SCr scr NN cord-015306-us58wwmp 3079 24 ) ) -RRB- cord-015306-us58wwmp 3079 25 ( ( -LRB- cord-015306-us58wwmp 3079 26 Schwartz Schwartz NNP cord-015306-us58wwmp 3079 27 formula formula NN cord-015306-us58wwmp 3079 28 [ [ -LRB- cord-015306-us58wwmp 3079 29 0.413*Ht 0.413*ht XX cord-015306-us58wwmp 3079 30 ( ( -LRB- cord-015306-us58wwmp 3079 31 cm)/SCr cm)/SCr NFP cord-015306-us58wwmp 3079 32 ( ( -LRB- cord-015306-us58wwmp 3079 33 mg mg NNP cord-015306-us58wwmp 3079 34 / / SYM cord-015306-us58wwmp 3079 35 dl dl NNP cord-015306-us58wwmp 3079 36 ) ) -RRB- cord-015306-us58wwmp 3079 37 ] ] -RRB- cord-015306-us58wwmp 3079 38 or or CC cord-015306-us58wwmp 3079 39 MDRD MDRD NNP cord-015306-us58wwmp 3079 40 formula formula NN cord-015306-us58wwmp 3079 41 were be VBD cord-015306-us58wwmp 3079 42 used use VBN cord-015306-us58wwmp 3079 43 to to TO cord-015306-us58wwmp 3079 44 estimate estimate VB cord-015306-us58wwmp 3079 45 GFR GFR NNP cord-015306-us58wwmp 3079 46 ) ) -RRB- cord-015306-us58wwmp 3079 47 and and CC cord-015306-us58wwmp 3079 48 urinary urinary JJ cord-015306-us58wwmp 3079 49 protein protein NN cord-015306-us58wwmp 3079 50 / / SYM cord-015306-us58wwmp 3079 51 creatinine creatinine NN cord-015306-us58wwmp 3079 52 ( ( -LRB- cord-015306-us58wwmp 3079 53 uP uP NNP cord-015306-us58wwmp 3079 54 / / SYM cord-015306-us58wwmp 3079 55 C c NN cord-015306-us58wwmp 3079 56 ) ) -RRB- cord-015306-us58wwmp 3079 57 ratio ratio NN cord-015306-us58wwmp 3079 58 . . . cord-015306-us58wwmp 3080 1 CKD CKD NNP cord-015306-us58wwmp 3080 2 was be VBD cord-015306-us58wwmp 3080 3 suspected suspect VBN cord-015306-us58wwmp 3080 4 in in IN cord-015306-us58wwmp 3080 5 patients patient NNS cord-015306-us58wwmp 3080 6 with with IN cord-015306-us58wwmp 3080 7 hypertension hypertension NN cord-015306-us58wwmp 3080 8 ( ( -LRB- cord-015306-us58wwmp 3080 9 > > XX cord-015306-us58wwmp 3081 1 95th 95th JJ cord-015306-us58wwmp 3081 2 percentile percentile NN cord-015306-us58wwmp 3081 3 of of IN cord-015306-us58wwmp 3081 4 reference reference NN cord-015306-us58wwmp 3081 5 values value NNS cord-015306-us58wwmp 3081 6 according accord VBG cord-015306-us58wwmp 3081 7 to to IN cord-015306-us58wwmp 3081 8 height height NN cord-015306-us58wwmp 3081 9 and and CC cord-015306-us58wwmp 3081 10 age age NN cord-015306-us58wwmp 3081 11 ) ) -RRB- cord-015306-us58wwmp 3081 12 , , , cord-015306-us58wwmp 3081 13 abnormal abnormal JJ cord-015306-us58wwmp 3081 14 eGFR egfr NN cord-015306-us58wwmp 3081 15 ( ( -LRB- cord-015306-us58wwmp 3081 16 < < NNP cord-015306-us58wwmp 3081 17 90 90 CD cord-015306-us58wwmp 3081 18 ml ml NN cord-015306-us58wwmp 3081 19 / / SYM cord-015306-us58wwmp 3081 20 min/1.73 min/1.73 JJ cord-015306-us58wwmp 3081 21 m m CD cord-015306-us58wwmp 3081 22 2 2 CD cord-015306-us58wwmp 3081 23 ) ) -RRB- cord-015306-us58wwmp 3081 24 or or CC cord-015306-us58wwmp 3081 25 proteinuria proteinuria NN cord-015306-us58wwmp 3081 26 ( ( -LRB- cord-015306-us58wwmp 3081 27 uP up RB cord-015306-us58wwmp 3081 28 / / SYM cord-015306-us58wwmp 3081 29 C c NN cord-015306-us58wwmp 3081 30 ratio ratio NN cord-015306-us58wwmp 3082 1 > > XX cord-015306-us58wwmp 3083 1 30 30 CD cord-015306-us58wwmp 3083 2 mg mg NN cord-015306-us58wwmp 3083 3 / / SYM cord-015306-us58wwmp 3083 4 mmol mmol JJ cord-015306-us58wwmp 3083 5 creatinine creatinine NN cord-015306-us58wwmp 3083 6 ) ) -RRB- cord-015306-us58wwmp 3083 7 . . . cord-015306-us58wwmp 3084 1 Patients patient NNS cord-015306-us58wwmp 3084 2 were be VBD cord-015306-us58wwmp 3084 3 excluded exclude VBN cord-015306-us58wwmp 3084 4 if if IN cord-015306-us58wwmp 3084 5 SCr SCr NNS cord-015306-us58wwmp 3084 6 was be VBD cord-015306-us58wwmp 3084 7 lacking lack VBG cord-015306-us58wwmp 3084 8 . . . cord-015306-us58wwmp 3085 1 Results result NNS cord-015306-us58wwmp 3085 2 : : : cord-015306-us58wwmp 3086 1 To to IN cord-015306-us58wwmp 3086 2 date date NN cord-015306-us58wwmp 3086 3 , , , cord-015306-us58wwmp 3086 4 132 132 CD cord-015306-us58wwmp 3086 5 children child NNS cord-015306-us58wwmp 3086 6 visited visit VBD cord-015306-us58wwmp 3086 7 the the DT cord-015306-us58wwmp 3086 8 FUP FUP NNP cord-015306-us58wwmp 3086 9 clinic clinic NN cord-015306-us58wwmp 3086 10 . . . cord-015306-us58wwmp 3087 1 Of of IN cord-015306-us58wwmp 3087 2 these these DT cord-015306-us58wwmp 3087 3 , , , cord-015306-us58wwmp 3087 4 4 4 CD cord-015306-us58wwmp 3087 5 ( ( -LRB- cord-015306-us58wwmp 3087 6 3 3 CD cord-015306-us58wwmp 3087 7 % % NN cord-015306-us58wwmp 3087 8 ) ) -RRB- cord-015306-us58wwmp 3087 9 were be VBD cord-015306-us58wwmp 3087 10 excluded exclude VBN cord-015306-us58wwmp 3087 11 because because IN cord-015306-us58wwmp 3087 12 of of IN cord-015306-us58wwmp 3087 13 pre pre JJ cord-015306-us58wwmp 3087 14 - - JJ cord-015306-us58wwmp 3087 15 existent existent JJ cord-015306-us58wwmp 3087 16 kidney kidney NN cord-015306-us58wwmp 3087 17 disease disease NN cord-015306-us58wwmp 3087 18 and and CC cord-015306-us58wwmp 3087 19 6 6 CD cord-015306-us58wwmp 3087 20 ( ( -LRB- cord-015306-us58wwmp 3087 21 5 5 CD cord-015306-us58wwmp 3087 22 % % NN cord-015306-us58wwmp 3087 23 ) ) -RRB- cord-015306-us58wwmp 3087 24 because because IN cord-015306-us58wwmp 3087 25 of of IN cord-015306-us58wwmp 3087 26 missing miss VBG cord-015306-us58wwmp 3087 27 SCr scr NN cord-015306-us58wwmp 3087 28 data datum NNS cord-015306-us58wwmp 3087 29 . . . cord-015306-us58wwmp 3088 1 Hence hence RB cord-015306-us58wwmp 3088 2 , , , cord-015306-us58wwmp 3088 3 122 122 CD cord-015306-us58wwmp 3088 4 children child NNS cord-015306-us58wwmp 3088 5 ( ( -LRB- cord-015306-us58wwmp 3088 6 44 44 CD cord-015306-us58wwmp 3088 7 % % NN cord-015306-us58wwmp 3088 8 female female NN cord-015306-us58wwmp 3088 9 ) ) -RRB- cord-015306-us58wwmp 3088 10 were be VBD cord-015306-us58wwmp 3088 11 screened screen VBN cord-015306-us58wwmp 3088 12 for for IN cord-015306-us58wwmp 3088 13 CKD CKD NNP cord-015306-us58wwmp 3088 14 . . . cord-015306-us58wwmp 3089 1 The the DT cord-015306-us58wwmp 3089 2 number number NN cord-015306-us58wwmp 3089 3 of of IN cord-015306-us58wwmp 3089 4 patients patient NNS cord-015306-us58wwmp 3089 5 per per IN cord-015306-us58wwmp 3089 6 FUP FUP NNP cord-015306-us58wwmp 3089 7 age age NN cord-015306-us58wwmp 3089 8 category category NN cord-015306-us58wwmp 3089 9 was be VBD cord-015306-us58wwmp 3089 10 17 17 CD cord-015306-us58wwmp 3089 11 < < XX cord-015306-us58wwmp 3089 12 5 5 CD cord-015306-us58wwmp 3089 13 years year NNS cord-015306-us58wwmp 3089 14 , , , cord-015306-us58wwmp 3089 15 56 56 CD cord-015306-us58wwmp 3089 16 between between IN cord-015306-us58wwmp 3089 17 5 5 CD cord-015306-us58wwmp 3089 18 - - SYM cord-015306-us58wwmp 3089 19 12 12 CD cord-015306-us58wwmp 3089 20 years year NNS cord-015306-us58wwmp 3089 21 , , , cord-015306-us58wwmp 3089 22 and and CC cord-015306-us58wwmp 3089 23 49 49 CD cord-015306-us58wwmp 3089 24 > > SYM cord-015306-us58wwmp 3089 25 12 12 CD cord-015306-us58wwmp 3089 26 years year NNS cord-015306-us58wwmp 3089 27 . . . cord-015306-us58wwmp 3090 1 BP BP NNP cord-015306-us58wwmp 3090 2 was be VBD cord-015306-us58wwmp 3090 3 within within IN cord-015306-us58wwmp 3090 4 normal normal JJ cord-015306-us58wwmp 3090 5 ranges range NNS cord-015306-us58wwmp 3090 6 in in IN cord-015306-us58wwmp 3090 7 all all DT cord-015306-us58wwmp 3090 8 children child NNS cord-015306-us58wwmp 3090 9 . . . cord-015306-us58wwmp 3091 1 In in IN cord-015306-us58wwmp 3091 2 13 13 CD cord-015306-us58wwmp 3091 3 ( ( -LRB- cord-015306-us58wwmp 3091 4 11 11 CD cord-015306-us58wwmp 3091 5 % % NN cord-015306-us58wwmp 3091 6 ) ) -RRB- cord-015306-us58wwmp 3091 7 children child NNS cord-015306-us58wwmp 3091 8 either either CC cord-015306-us58wwmp 3091 9 an an DT cord-015306-us58wwmp 3091 10 abnormal abnormal JJ cord-015306-us58wwmp 3091 11 uP up RP cord-015306-us58wwmp 3091 12 / / SYM cord-015306-us58wwmp 3091 13 C c NN cord-015306-us58wwmp 3091 14 ratio ratio NN cord-015306-us58wwmp 3091 15 or or CC cord-015306-us58wwmp 3091 16 eGFR egfr NN cord-015306-us58wwmp 3091 17 was be VBD cord-015306-us58wwmp 3091 18 observed observe VBN cord-015306-us58wwmp 3091 19 . . . cord-015306-us58wwmp 3092 1 uP up RB cord-015306-us58wwmp 3092 2 / / SYM cord-015306-us58wwmp 3092 3 C c NN cord-015306-us58wwmp 3092 4 ratio ratio NN cord-015306-us58wwmp 3092 5 was be VBD cord-015306-us58wwmp 3092 6 increased increase VBN cord-015306-us58wwmp 3092 7 ( ( -LRB- cord-015306-us58wwmp 3092 8 median median JJ cord-015306-us58wwmp 3092 9 36 36 CD cord-015306-us58wwmp 3092 10 [ [ -LRB- cord-015306-us58wwmp 3092 11 IQR IQR NNP cord-015306-us58wwmp 3092 12 32 32 CD cord-015306-us58wwmp 3092 13 - - SYM cord-015306-us58wwmp 3092 14 38 38 CD cord-015306-us58wwmp 3092 15 mg mg NNP cord-015306-us58wwmp 3092 16 / / SYM cord-015306-us58wwmp 3092 17 mmol mmol JJ cord-015306-us58wwmp 3092 18 creatinine creatinine NN cord-015306-us58wwmp 3092 19 ] ] -RRB- cord-015306-us58wwmp 3092 20 ) ) -RRB- cord-015306-us58wwmp 3092 21 in in IN cord-015306-us58wwmp 3092 22 8 8 CD cord-015306-us58wwmp 3092 23 ( ( -LRB- cord-015306-us58wwmp 3092 24 7 7 CD cord-015306-us58wwmp 3092 25 % % NN cord-015306-us58wwmp 3092 26 ) ) -RRB- cord-015306-us58wwmp 3092 27 children child NNS cord-015306-us58wwmp 3092 28 , , , cord-015306-us58wwmp 3092 29 of of IN cord-015306-us58wwmp 3092 30 which which WDT cord-015306-us58wwmp 3092 31 1 1 CD cord-015306-us58wwmp 3092 32 was be VBD cord-015306-us58wwmp 3092 33 explained explain VBN cord-015306-us58wwmp 3092 34 by by IN cord-015306-us58wwmp 3092 35 low low JJ cord-015306-us58wwmp 3092 36 muscle muscle NN cord-015306-us58wwmp 3092 37 mass mass NN cord-015306-us58wwmp 3092 38 . . . cord-015306-us58wwmp 3093 1 Only only RB cord-015306-us58wwmp 3093 2 5 5 CD cord-015306-us58wwmp 3093 3 ( ( -LRB- cord-015306-us58wwmp 3093 4 4 4 CD cord-015306-us58wwmp 3093 5 % % NN cord-015306-us58wwmp 3093 6 ) ) -RRB- cord-015306-us58wwmp 3093 7 children child NNS cord-015306-us58wwmp 3093 8 had have VBD cord-015306-us58wwmp 3093 9 an an DT cord-015306-us58wwmp 3093 10 abnormal abnormal JJ cord-015306-us58wwmp 3093 11 eGFR egfr NN cord-015306-us58wwmp 3094 1 but but CC cord-015306-us58wwmp 3094 2 all all DT cord-015306-us58wwmp 3094 3 > > XX cord-015306-us58wwmp 3094 4 60 60 CD cord-015306-us58wwmp 3094 5 ml ml NN cord-015306-us58wwmp 3094 6 / / SYM cord-015306-us58wwmp 3094 7 min/1.73 min/1.73 JJ cord-015306-us58wwmp 3094 8 m m CD cord-015306-us58wwmp 3094 9 2 2 CD cord-015306-us58wwmp 3094 10 . . . cord-015306-us58wwmp 3095 1 Conclusion conclusion NN cord-015306-us58wwmp 3095 2 : : : cord-015306-us58wwmp 3096 1 The the DT cord-015306-us58wwmp 3096 2 prevalence prevalence NN cord-015306-us58wwmp 3096 3 of of IN cord-015306-us58wwmp 3096 4 CKD CKD NNP cord-015306-us58wwmp 3096 5 and and CC cord-015306-us58wwmp 3096 6 its -PRON- PRP$ cord-015306-us58wwmp 3096 7 clinical clinical JJ cord-015306-us58wwmp 3096 8 implication implication NN cord-015306-us58wwmp 3096 9 in in IN cord-015306-us58wwmp 3096 10 children child NNS cord-015306-us58wwmp 3096 11 previously previously RB cord-015306-us58wwmp 3096 12 treated treat VBN cord-015306-us58wwmp 3096 13 with with IN cord-015306-us58wwmp 3096 14 neonatal neonatal JJ cord-015306-us58wwmp 3096 15 ECMO ECMO NNP cord-015306-us58wwmp 3096 16 seems seem VBZ cord-015306-us58wwmp 3096 17 to to TO cord-015306-us58wwmp 3096 18 be be VB cord-015306-us58wwmp 3096 19 limited limit VBN cord-015306-us58wwmp 3096 20 . . . cord-015306-us58wwmp 3097 1 Future future JJ cord-015306-us58wwmp 3097 2 research research NN cord-015306-us58wwmp 3097 3 will will MD cord-015306-us58wwmp 3097 4 focus focus VB cord-015306-us58wwmp 3097 5 on on IN cord-015306-us58wwmp 3097 6 identifying identify VBG cord-015306-us58wwmp 3097 7 risk risk NN cord-015306-us58wwmp 3097 8 factors factor NNS cord-015306-us58wwmp 3097 9 for for IN cord-015306-us58wwmp 3097 10 CKD CKD NNP cord-015306-us58wwmp 3097 11 following follow VBG cord-015306-us58wwmp 3097 12 ECMO ECMO NNP cord-015306-us58wwmp 3097 13 support support NN cord-015306-us58wwmp 3097 14 . . . cord-015306-us58wwmp 3098 1 Abstract abstract JJ cord-015306-us58wwmp 3098 2 # # NN cord-015306-us58wwmp 3098 3 P p NN cord-015306-us58wwmp 3098 4 - - HYPH cord-015306-us58wwmp 3098 5 SAT336 sat336 JJ cord-015306-us58wwmp 3098 6 10 10 CD cord-015306-us58wwmp 3098 7 years year NNS cord-015306-us58wwmp 3098 8 clinical clinical JJ cord-015306-us58wwmp 3098 9 retrospective retrospective JJ cord-015306-us58wwmp 3098 10 analysis analysis NN cord-015306-us58wwmp 3098 11 in in IN cord-015306-us58wwmp 3098 12 children child NNS cord-015306-us58wwmp 3098 13 of of IN cord-015306-us58wwmp 3098 14 acute acute JJ cord-015306-us58wwmp 3098 15 poisoning poisoning NN cord-015306-us58wwmp 3098 16 inpatient inpatient NN cord-015306-us58wwmp 3098 17 Man Man NNP cord-015306-us58wwmp 3098 18 Jiang Jiang NNP cord-015306-us58wwmp 3098 19 , , , cord-015306-us58wwmp 3098 20 Qiu Qiu NNP cord-015306-us58wwmp 3098 21 Li Li NNP cord-015306-us58wwmp 3098 22 Nephrology Nephrology NNP cord-015306-us58wwmp 3098 23 and and CC cord-015306-us58wwmp 3098 24 immunology immunology NN cord-015306-us58wwmp 3098 25 department department NN cord-015306-us58wwmp 3098 26 , , , cord-015306-us58wwmp 3098 27 Children Children NNP cord-015306-us58wwmp 3098 28 's 's POS cord-015306-us58wwmp 3098 29 hospital hospital NN cord-015306-us58wwmp 3098 30 of of IN cord-015306-us58wwmp 3098 31 Chongqing Chongqing NNP cord-015306-us58wwmp 3098 32 medical medical JJ cord-015306-us58wwmp 3098 33 university university NN cord-015306-us58wwmp 3098 34 , , , cord-015306-us58wwmp 3098 35 Chongqing Chongqing NNP cord-015306-us58wwmp 3098 36 , , , cord-015306-us58wwmp 3099 1 China China NNP cord-015306-us58wwmp 3099 2 Objective Objective NNP cord-015306-us58wwmp 3099 3 : : : cord-015306-us58wwmp 3100 1 Acute acute JJ cord-015306-us58wwmp 3100 2 poisoning poisoning NN cord-015306-us58wwmp 3100 3 is be VBZ cord-015306-us58wwmp 3100 4 the the DT cord-015306-us58wwmp 3100 5 common common JJ cord-015306-us58wwmp 3100 6 critical critical JJ cord-015306-us58wwmp 3100 7 and and CC cord-015306-us58wwmp 3100 8 emergency emergency NN cord-015306-us58wwmp 3100 9 disease disease NN cord-015306-us58wwmp 3100 10 in in IN cord-015306-us58wwmp 3100 11 children child NNS cord-015306-us58wwmp 3100 12 . . . cord-015306-us58wwmp 3101 1 Since since IN cord-015306-us58wwmp 3101 2 childhood childhood NN cord-015306-us58wwmp 3101 3 is be VBZ cord-015306-us58wwmp 3101 4 the the DT cord-015306-us58wwmp 3101 5 special special JJ cord-015306-us58wwmp 3101 6 life life NN cord-015306-us58wwmp 3101 7 stage stage NN cord-015306-us58wwmp 3101 8 with with IN cord-015306-us58wwmp 3101 9 continuous continuous JJ cord-015306-us58wwmp 3101 10 growth growth NN cord-015306-us58wwmp 3101 11 , , , cord-015306-us58wwmp 3101 12 clinical clinical JJ cord-015306-us58wwmp 3101 13 features feature NNS cord-015306-us58wwmp 3101 14 are be VBP cord-015306-us58wwmp 3101 15 different different JJ cord-015306-us58wwmp 3101 16 from from IN cord-015306-us58wwmp 3101 17 the the DT cord-015306-us58wwmp 3101 18 adult adult NN cord-015306-us58wwmp 3101 19 and and CC cord-015306-us58wwmp 3101 20 changes change NNS cord-015306-us58wwmp 3101 21 were be VBD cord-015306-us58wwmp 3101 22 happened happen VBN cord-015306-us58wwmp 3101 23 in in IN cord-015306-us58wwmp 3101 24 resent resent NN cord-015306-us58wwmp 3101 25 years year NNS cord-015306-us58wwmp 3101 26 . . . cord-015306-us58wwmp 3102 1 The the DT cord-015306-us58wwmp 3102 2 change change NN cord-015306-us58wwmp 3102 3 rules rule NNS cord-015306-us58wwmp 3102 4 , , , cord-015306-us58wwmp 3102 5 clinical clinical JJ cord-015306-us58wwmp 3102 6 features feature NNS cord-015306-us58wwmp 3102 7 , , , cord-015306-us58wwmp 3102 8 treatments treatment NNS cord-015306-us58wwmp 3102 9 and and CC cord-015306-us58wwmp 3102 10 the the DT cord-015306-us58wwmp 3102 11 outcomes outcome NNS cord-015306-us58wwmp 3102 12 of of IN cord-015306-us58wwmp 3102 13 acute acute JJ cord-015306-us58wwmp 3102 14 pediatric pediatric JJ cord-015306-us58wwmp 3102 15 poisonings poisoning NNS cord-015306-us58wwmp 3102 16 inpatients inpatient NNS cord-015306-us58wwmp 3102 17 were be VBD cord-015306-us58wwmp 3102 18 investigated investigate VBN cord-015306-us58wwmp 3102 19 in in IN cord-015306-us58wwmp 3102 20 this this DT cord-015306-us58wwmp 3102 21 article article NN cord-015306-us58wwmp 3102 22 . . . cord-015306-us58wwmp 3103 1 Methods method NNS cord-015306-us58wwmp 3103 2 : : : cord-015306-us58wwmp 3104 1 Retrospective Retrospective NNP cord-015306-us58wwmp 3104 2 evaluated evaluate VBD cord-015306-us58wwmp 3104 3 the the DT cord-015306-us58wwmp 3104 4 1005 1005 CD cord-015306-us58wwmp 3104 5 cases case NNS cord-015306-us58wwmp 3104 6 of of IN cord-015306-us58wwmp 3104 7 pediatric pediatric JJ cord-015306-us58wwmp 3104 8 acute acute JJ cord-015306-us58wwmp 3104 9 poisonings poisoning NNS cord-015306-us58wwmp 3104 10 admitted admit VBD cord-015306-us58wwmp 3104 11 to to IN cord-015306-us58wwmp 3104 12 the the DT cord-015306-us58wwmp 3104 13 Children Children NNPS cord-015306-us58wwmp 3104 14 's 's POS cord-015306-us58wwmp 3104 15 Hospital Hospital NNP cord-015306-us58wwmp 3104 16 of of IN cord-015306-us58wwmp 3104 17 Chongqing Chongqing NNP cord-015306-us58wwmp 3104 18 Medical Medical NNP cord-015306-us58wwmp 3104 19 University University NNP cord-015306-us58wwmp 3104 20 . . . cord-015306-us58wwmp 3105 1 Cases case NNS cord-015306-us58wwmp 3105 2 were be VBD cord-015306-us58wwmp 3105 3 divided divide VBN cord-015306-us58wwmp 3105 4 into into IN cord-015306-us58wwmp 3105 5 5 5 CD cord-015306-us58wwmp 3105 6 groups group NNS cord-015306-us58wwmp 3105 7 by by IN cord-015306-us58wwmp 3105 8 ages age NNS cord-015306-us58wwmp 3105 9 , , , cord-015306-us58wwmp 3105 10 or or CC cord-015306-us58wwmp 3105 11 divided divide VBN cord-015306-us58wwmp 3105 12 into into IN cord-015306-us58wwmp 3105 13 2 2 CD cord-015306-us58wwmp 3105 14 groups group NNS cord-015306-us58wwmp 3105 15 based base VBN cord-015306-us58wwmp 3105 16 on on IN cord-015306-us58wwmp 3105 17 different different JJ cord-015306-us58wwmp 3105 18 origins origin NNS cord-015306-us58wwmp 3105 19 ( ( -LRB- cord-015306-us58wwmp 3105 20 urban urban JJ cord-015306-us58wwmp 3105 21 or or CC cord-015306-us58wwmp 3105 22 suburban suburban JJ cord-015306-us58wwmp 3105 23 ) ) -RRB- cord-015306-us58wwmp 3105 24 , , , cord-015306-us58wwmp 3105 25 different different JJ cord-015306-us58wwmp 3105 26 causes cause NNS cord-015306-us58wwmp 3105 27 and and CC cord-015306-us58wwmp 3105 28 routes route NNS cord-015306-us58wwmp 3105 29 of of IN cord-015306-us58wwmp 3105 30 poisonings poisoning NNS cord-015306-us58wwmp 3105 31 in in IN cord-015306-us58wwmp 3105 32 different different JJ cord-015306-us58wwmp 3105 33 groups group NNS cord-015306-us58wwmp 3105 34 were be VBD cord-015306-us58wwmp 3105 35 calculated calculate VBN cord-015306-us58wwmp 3105 36 . . . cord-015306-us58wwmp 3106 1 The the DT cord-015306-us58wwmp 3106 2 clinical clinical JJ cord-015306-us58wwmp 3106 3 manifestations manifestation NNS cord-015306-us58wwmp 3106 4 , , , cord-015306-us58wwmp 3106 5 treatments treatment NNS cord-015306-us58wwmp 3106 6 and and CC cord-015306-us58wwmp 3106 7 prognosis prognosis NN cord-015306-us58wwmp 3106 8 in in IN cord-015306-us58wwmp 3106 9 acute acute JJ cord-015306-us58wwmp 3106 10 intoxication intoxication NN cord-015306-us58wwmp 3106 11 were be VBD cord-015306-us58wwmp 3106 12 also also RB cord-015306-us58wwmp 3106 13 studied study VBN cord-015306-us58wwmp 3106 14 . . . cord-015306-us58wwmp 3107 1 Results result NNS cord-015306-us58wwmp 3107 2 and and CC cord-015306-us58wwmp 3107 3 Conclusion conclusion NN cord-015306-us58wwmp 3107 4 : : : cord-015306-us58wwmp 3107 5 Pediatric pediatric JJ cord-015306-us58wwmp 3107 6 acute acute JJ cord-015306-us58wwmp 3107 7 poisoning poisoning NN cord-015306-us58wwmp 3107 8 mainly mainly RB cord-015306-us58wwmp 3107 9 happened happen VBD cord-015306-us58wwmp 3107 10 in in IN cord-015306-us58wwmp 3107 11 1 1 CD cord-015306-us58wwmp 3107 12 - - SYM cord-015306-us58wwmp 3107 13 4 4 CD cord-015306-us58wwmp 3107 14 years year NNS cord-015306-us58wwmp 3107 15 old old JJ cord-015306-us58wwmp 3107 16 children child NNS cord-015306-us58wwmp 3107 17 ( ( -LRB- cord-015306-us58wwmp 3107 18 50.02 50.02 CD cord-015306-us58wwmp 3107 19 % % NN cord-015306-us58wwmp 3107 20 ) ) -RRB- cord-015306-us58wwmp 3107 21 , , , cord-015306-us58wwmp 3107 22 there there EX cord-015306-us58wwmp 3107 23 was be VBD cord-015306-us58wwmp 3107 24 no no DT cord-015306-us58wwmp 3107 25 statistical statistical JJ cord-015306-us58wwmp 3107 26 difference difference NN cord-015306-us58wwmp 3107 27 between between IN cord-015306-us58wwmp 3107 28 genders gender NNS cord-015306-us58wwmp 3107 29 . . . cord-015306-us58wwmp 3108 1 The the DT cord-015306-us58wwmp 3108 2 common common JJ cord-015306-us58wwmp 3108 3 causes cause NNS cord-015306-us58wwmp 3108 4 of of IN cord-015306-us58wwmp 3108 5 poisonings poisoning NNS cord-015306-us58wwmp 3108 6 were be VBD cord-015306-us58wwmp 3108 7 pharmacological pharmacological JJ cord-015306-us58wwmp 3108 8 poisoning poisoning NN cord-015306-us58wwmp 3108 9 ( ( -LRB- cord-015306-us58wwmp 3108 10 26.07 26.07 CD cord-015306-us58wwmp 3108 11 % % NN cord-015306-us58wwmp 3108 12 ) ) -RRB- cord-015306-us58wwmp 3108 13 , , , cord-015306-us58wwmp 3108 14 food food NN cord-015306-us58wwmp 3108 15 poisoning poisoning NN cord-015306-us58wwmp 3108 16 ( ( -LRB- cord-015306-us58wwmp 3108 17 19.50 19.50 CD cord-015306-us58wwmp 3108 18 % % NN cord-015306-us58wwmp 3108 19 ) ) -RRB- cord-015306-us58wwmp 3108 20 , , , cord-015306-us58wwmp 3108 21 animal animal NN cord-015306-us58wwmp 3108 22 bites bite NNS cord-015306-us58wwmp 3108 23 and and CC cord-015306-us58wwmp 3108 24 stings sting NNS cord-015306-us58wwmp 3108 25 ( ( -LRB- cord-015306-us58wwmp 3108 26 16.92 16.92 CD cord-015306-us58wwmp 3108 27 % % NN cord-015306-us58wwmp 3108 28 ) ) -RRB- cord-015306-us58wwmp 3108 29 and and CC cord-015306-us58wwmp 3108 30 pesticide pesticide NN cord-015306-us58wwmp 3108 31 poisoning poisoning NN cord-015306-us58wwmp 3108 32 ( ( -LRB- cord-015306-us58wwmp 3108 33 14.73 14.73 CD cord-015306-us58wwmp 3108 34 % % NN cord-015306-us58wwmp 3108 35 ) ) -RRB- cord-015306-us58wwmp 3108 36 . . . cord-015306-us58wwmp 3109 1 In in IN cord-015306-us58wwmp 3109 2 the the DT cord-015306-us58wwmp 3109 3 resent resent NN cord-015306-us58wwmp 3109 4 five five CD cord-015306-us58wwmp 3109 5 years year NNS cord-015306-us58wwmp 3109 6 , , , cord-015306-us58wwmp 3109 7 Pharmacological pharmacological JJ cord-015306-us58wwmp 3109 8 poisoning poisoning NN cord-015306-us58wwmp 3109 9 rose rise VBD cord-015306-us58wwmp 3109 10 to to TO cord-015306-us58wwmp 3109 11 be be VB cord-015306-us58wwmp 3109 12 the the DT cord-015306-us58wwmp 3109 13 top top JJ cord-015306-us58wwmp 3109 14 reason reason NN cord-015306-us58wwmp 3109 15 of of IN cord-015306-us58wwmp 3109 16 poisonings poisoning NNS cord-015306-us58wwmp 3109 17 , , , cord-015306-us58wwmp 3109 18 and and CC cord-015306-us58wwmp 3109 19 was be VBD cord-015306-us58wwmp 3109 20 mainly mainly RB cord-015306-us58wwmp 3109 21 composed compose VBN cord-015306-us58wwmp 3109 22 by by IN cord-015306-us58wwmp 3109 23 children≤3 children≤3 VBN cord-015306-us58wwmp 3110 1 years year NNS cord-015306-us58wwmp 3110 2 old old JJ cord-015306-us58wwmp 3110 3 ( ( -LRB- cord-015306-us58wwmp 3110 4 P p NN cord-015306-us58wwmp 3110 5 < < XX cord-015306-us58wwmp 3110 6 0.001),and 0.001),and CD cord-015306-us58wwmp 3110 7 urban urban JJ cord-015306-us58wwmp 3110 8 children child NNS cord-015306-us58wwmp 3110 9 were be VBD cord-015306-us58wwmp 3110 10 more more JJR cord-015306-us58wwmp 3110 11 than than IN cord-015306-us58wwmp 3110 12 children child NNS cord-015306-us58wwmp 3110 13 from from IN cord-015306-us58wwmp 3110 14 suburban(P suburban(p NN cord-015306-us58wwmp 3110 15 < < XX cord-015306-us58wwmp 3110 16 0.001 0.001 CD cord-015306-us58wwmp 3110 17 ) ) -RRB- cord-015306-us58wwmp 3110 18 . . . cord-015306-us58wwmp 3111 1 Neurological neurological JJ cord-015306-us58wwmp 3111 2 and and CC cord-015306-us58wwmp 3111 3 psychiatric psychiatric JJ cord-015306-us58wwmp 3111 4 drugs drug NNS cord-015306-us58wwmp 3111 5 were be VBD cord-015306-us58wwmp 3111 6 the the DT cord-015306-us58wwmp 3111 7 most most RBS cord-015306-us58wwmp 3111 8 common common JJ cord-015306-us58wwmp 3111 9 ( ( -LRB- cord-015306-us58wwmp 3111 10 32.06 32.06 CD cord-015306-us58wwmp 3111 11 % % NN cord-015306-us58wwmp 3111 12 ) ) -RRB- cord-015306-us58wwmp 3111 13 in in IN cord-015306-us58wwmp 3111 14 drug drug NN cord-015306-us58wwmp 3111 15 poisoning poisoning NN cord-015306-us58wwmp 3111 16 . . . cord-015306-us58wwmp 3112 1 Rural rural JJ cord-015306-us58wwmp 3112 2 children child NNS cord-015306-us58wwmp 3112 3 with with IN cord-015306-us58wwmp 3112 4 animal animal NN cord-015306-us58wwmp 3112 5 bites bite NNS cord-015306-us58wwmp 3112 6 and and CC cord-015306-us58wwmp 3112 7 stings sting NNS cord-015306-us58wwmp 3112 8 , , , cord-015306-us58wwmp 3112 9 pesticide pesticide NN cord-015306-us58wwmp 3112 10 poisonings poisoning NNS cord-015306-us58wwmp 3112 11 and and CC cord-015306-us58wwmp 3112 12 rodenticide rodenticide NN cord-015306-us58wwmp 3112 13 poisonings poisoning NNS cord-015306-us58wwmp 3112 14 were be VBD cord-015306-us58wwmp 3112 15 more more JJR cord-015306-us58wwmp 3112 16 than than IN cord-015306-us58wwmp 3112 17 the the DT cord-015306-us58wwmp 3112 18 urban urban JJ cord-015306-us58wwmp 3112 19 children child NNS cord-015306-us58wwmp 3112 20 ( ( -LRB- cord-015306-us58wwmp 3112 21 P p NN cord-015306-us58wwmp 3112 22 < < XX cord-015306-us58wwmp 3112 23 0.001 0.001 CD cord-015306-us58wwmp 3112 24 , , , cord-015306-us58wwmp 3112 25 P p NN cord-015306-us58wwmp 3112 26 < < XX cord-015306-us58wwmp 3112 27 0.001 0.001 CD cord-015306-us58wwmp 3112 28 , , , cord-015306-us58wwmp 3112 29 P p NN cord-015306-us58wwmp 3112 30 < < XX cord-015306-us58wwmp 3112 31 0.05 0.05 CD cord-015306-us58wwmp 3112 32 ) ) -RRB- cord-015306-us58wwmp 3112 33 . . . cord-015306-us58wwmp 3113 1 The the DT cord-015306-us58wwmp 3113 2 main main JJ cord-015306-us58wwmp 3113 3 poisoning poisoning NN cord-015306-us58wwmp 3113 4 causes cause NNS cord-015306-us58wwmp 3113 5 in in IN cord-015306-us58wwmp 3113 6 6 6 CD cord-015306-us58wwmp 3113 7 - - SYM cord-015306-us58wwmp 3113 8 12 12 CD cord-015306-us58wwmp 3113 9 years year NNS cord-015306-us58wwmp 3113 10 old old JJ cord-015306-us58wwmp 3113 11 group group NN cord-015306-us58wwmp 3113 12 and and CC cord-015306-us58wwmp 3113 13 > > XX cord-015306-us58wwmp 3113 14 12 12 CD cord-015306-us58wwmp 3113 15 years year NNS cord-015306-us58wwmp 3113 16 old old JJ cord-015306-us58wwmp 3113 17 group group NN cord-015306-us58wwmp 3113 18 children child NNS cord-015306-us58wwmp 3113 19 were be VBD cord-015306-us58wwmp 3113 20 food food NN cord-015306-us58wwmp 3113 21 poisoning poisoning NN cord-015306-us58wwmp 3113 22 ( ( -LRB- cord-015306-us58wwmp 3113 23 29.20 29.20 CD cord-015306-us58wwmp 3113 24 % % NN cord-015306-us58wwmp 3113 25 ) ) -RRB- cord-015306-us58wwmp 3113 26 and and CC cord-015306-us58wwmp 3113 27 pesticide pesticide NN cord-015306-us58wwmp 3113 28 poisoning poisoning NN cord-015306-us58wwmp 3113 29 ( ( -LRB- cord-015306-us58wwmp 3113 30 Objective objective NN cord-015306-us58wwmp 3113 31 : : : cord-015306-us58wwmp 3114 1 Little little JJ cord-015306-us58wwmp 3114 2 is be VBZ cord-015306-us58wwmp 3114 3 known know VBN cord-015306-us58wwmp 3114 4 about about IN cord-015306-us58wwmp 3114 5 cardiac cardiac JJ cord-015306-us58wwmp 3114 6 surgery surgery NN cord-015306-us58wwmp 3114 7 - - HYPH cord-015306-us58wwmp 3114 8 associated associate VBN cord-015306-us58wwmp 3114 9 acute acute JJ cord-015306-us58wwmp 3114 10 kidney kidney NN cord-015306-us58wwmp 3114 11 injury injury NN cord-015306-us58wwmp 3114 12 ( ( -LRB- cord-015306-us58wwmp 3114 13 CS CS NNP cord-015306-us58wwmp 3114 14 - - HYPH cord-015306-us58wwmp 3114 15 AKI AKI NNP cord-015306-us58wwmp 3114 16 ) ) -RRB- cord-015306-us58wwmp 3114 17 in in IN cord-015306-us58wwmp 3114 18 children child NNS cord-015306-us58wwmp 3114 19 in in IN cord-015306-us58wwmp 3114 20 developing develop VBG cord-015306-us58wwmp 3114 21 regions region NNS cord-015306-us58wwmp 3114 22 of of IN cord-015306-us58wwmp 3114 23 the the DT cord-015306-us58wwmp 3114 24 world world NN cord-015306-us58wwmp 3114 25 . . . cord-015306-us58wwmp 3115 1 The the DT cord-015306-us58wwmp 3115 2 study study NN cord-015306-us58wwmp 3115 3 aimed aim VBD cord-015306-us58wwmp 3115 4 to to TO cord-015306-us58wwmp 3115 5 determine determine VB cord-015306-us58wwmp 3115 6 the the DT cord-015306-us58wwmp 3115 7 prevalence prevalence NN cord-015306-us58wwmp 3115 8 of of IN cord-015306-us58wwmp 3115 9 CS CS NNP cord-015306-us58wwmp 3115 10 - - HYPH cord-015306-us58wwmp 3115 11 AKI AKI NNP cord-015306-us58wwmp 3115 12 , , , cord-015306-us58wwmp 3115 13 associated associated JJ cord-015306-us58wwmp 3115 14 factors factor NNS cord-015306-us58wwmp 3115 15 and and CC cord-015306-us58wwmp 3115 16 its -PRON- PRP$ cord-015306-us58wwmp 3115 17 impact impact NN cord-015306-us58wwmp 3115 18 on on IN cord-015306-us58wwmp 3115 19 mortality mortality NN cord-015306-us58wwmp 3115 20 and and CC cord-015306-us58wwmp 3115 21 utilization utilization NN cord-015306-us58wwmp 3115 22 of of IN cord-015306-us58wwmp 3115 23 hospital hospital NN cord-015306-us58wwmp 3115 24 services service NNS cord-015306-us58wwmp 3115 25 . . . cord-015306-us58wwmp 3116 1 Methods method NNS cord-015306-us58wwmp 3116 2 : : : cord-015306-us58wwmp 3116 3 Hospital hospital NN cord-015306-us58wwmp 3116 4 records record NNS cord-015306-us58wwmp 3116 5 of of IN cord-015306-us58wwmp 3116 6 children child NNS cord-015306-us58wwmp 3116 7 aged age VBN cord-015306-us58wwmp 3116 8 0 0 CD cord-015306-us58wwmp 3116 9 - - SYM cord-015306-us58wwmp 3116 10 17 17 CD cord-015306-us58wwmp 3116 11 years year NNS cord-015306-us58wwmp 3116 12 that that WDT cord-015306-us58wwmp 3116 13 underwent undergo VBD cord-015306-us58wwmp 3116 14 cardiac cardiac JJ cord-015306-us58wwmp 3116 15 surgery surgery NN cord-015306-us58wwmp 3116 16 ( ( -LRB- cord-015306-us58wwmp 3116 17 other other JJ cord-015306-us58wwmp 3116 18 than than IN cord-015306-us58wwmp 3116 19 device device NN cord-015306-us58wwmp 3116 20 closure closure NN cord-015306-us58wwmp 3116 21 procedures procedure NNS cord-015306-us58wwmp 3116 22 and and CC cord-015306-us58wwmp 3116 23 pacemaker pacemaker NN cord-015306-us58wwmp 3116 24 insertion insertion NN cord-015306-us58wwmp 3116 25 only only RB cord-015306-us58wwmp 3116 26 ) ) -RRB- cord-015306-us58wwmp 3116 27 at at IN cord-015306-us58wwmp 3116 28 an an DT cord-015306-us58wwmp 3116 29 Indian indian JJ cord-015306-us58wwmp 3116 30 hospital hospital NN cord-015306-us58wwmp 3116 31 between between IN cord-015306-us58wwmp 3116 32 2011 2011 CD cord-015306-us58wwmp 3116 33 and and CC cord-015306-us58wwmp 3116 34 2012 2012 CD cord-015306-us58wwmp 3116 35 were be VBD cord-015306-us58wwmp 3116 36 reviewed review VBN cord-015306-us58wwmp 3116 37 . . . cord-015306-us58wwmp 3117 1 CS CS NNP cord-015306-us58wwmp 3117 2 - - HYPH cord-015306-us58wwmp 3117 3 AKI AKI NNP cord-015306-us58wwmp 3117 4 was be VBD cord-015306-us58wwmp 3117 5 defined define VBN cord-015306-us58wwmp 3117 6 as as IN cord-015306-us58wwmp 3117 7 a a DT cord-015306-us58wwmp 3117 8 rise rise NN cord-015306-us58wwmp 3117 9 in in IN cord-015306-us58wwmp 3117 10 serum serum NN cord-015306-us58wwmp 3117 11 creatinine creatinine NN cord-015306-us58wwmp 3117 12 of of IN cord-015306-us58wwmp 3117 13 ≥0.3 ≥0.3 NNP cord-015306-us58wwmp 3117 14 mg mg NNP cord-015306-us58wwmp 3117 15 / / SYM cord-015306-us58wwmp 3117 16 dl dl NNP cord-015306-us58wwmp 3117 17 in in IN cord-015306-us58wwmp 3117 18 any any DT cord-015306-us58wwmp 3117 19 48 48 CD cord-015306-us58wwmp 3117 20 hours hour NNS cord-015306-us58wwmp 3117 21 and and CC cord-015306-us58wwmp 3117 22 or or CC cord-015306-us58wwmp 3117 23 by by IN cord-015306-us58wwmp 3117 24 urine urine NN cord-015306-us58wwmp 3117 25 output output NN cord-015306-us58wwmp 3117 26 less less JJR cord-015306-us58wwmp 3117 27 than than IN cord-015306-us58wwmp 3117 28 0.5ml 0.5ml CD cord-015306-us58wwmp 3118 1 /kg /kg NFP cord-015306-us58wwmp 3118 2 / / SYM cord-015306-us58wwmp 3118 3 hr hr NN cord-015306-us58wwmp 3118 4 for for IN cord-015306-us58wwmp 3118 5 an an DT cord-015306-us58wwmp 3118 6 8-hour 8-hour CD cord-015306-us58wwmp 3118 7 period period NN cord-015306-us58wwmp 3118 8 in in IN cord-015306-us58wwmp 3118 9 the the DT cord-015306-us58wwmp 3118 10 first first JJ cord-015306-us58wwmp 3118 11 5 5 CD cord-015306-us58wwmp 3118 12 days day NNS cord-015306-us58wwmp 3118 13 after after IN cord-015306-us58wwmp 3118 14 cardiac cardiac JJ cord-015306-us58wwmp 3118 15 surgery surgery NN cord-015306-us58wwmp 3118 16 . . . cord-015306-us58wwmp 3119 1 Results result NNS cord-015306-us58wwmp 3119 2 : : : cord-015306-us58wwmp 3120 1 The the DT cord-015306-us58wwmp 3120 2 study study NN cord-015306-us58wwmp 3120 3 included include VBD cord-015306-us58wwmp 3120 4 323 323 CD cord-015306-us58wwmp 3120 5 children child NNS cord-015306-us58wwmp 3120 6 with with IN cord-015306-us58wwmp 3120 7 a a DT cord-015306-us58wwmp 3120 8 median median JJ cord-015306-us58wwmp 3120 9 age age NN cord-015306-us58wwmp 3120 10 of of IN cord-015306-us58wwmp 3120 11 1 1 CD cord-015306-us58wwmp 3120 12 year year NN cord-015306-us58wwmp 3120 13 ( ( -LRB- cord-015306-us58wwmp 3120 14 0.04 0.04 CD cord-015306-us58wwmp 3120 15 - - SYM cord-015306-us58wwmp 3120 16 17 17 CD cord-015306-us58wwmp 3120 17 ) ) -RRB- cord-015306-us58wwmp 3120 18 , , , cord-015306-us58wwmp 3120 19 of of IN cord-015306-us58wwmp 3120 20 which which WDT cord-015306-us58wwmp 3120 21 22 22 CD cord-015306-us58wwmp 3120 22 ( ( -LRB- cord-015306-us58wwmp 3120 23 6.8 6.8 CD cord-015306-us58wwmp 3120 24 % % NN cord-015306-us58wwmp 3120 25 ) ) -RRB- cord-015306-us58wwmp 3120 26 were be VBD cord-015306-us58wwmp 3120 27 neonates neonate NNS cord-015306-us58wwmp 3120 28 and and CC cord-015306-us58wwmp 3120 29 18.3 18.3 CD cord-015306-us58wwmp 3120 30 % % NN cord-015306-us58wwmp 3120 31 had have VBD cord-015306-us58wwmp 3120 32 single single JJ cord-015306-us58wwmp 3120 33 ventricle ventricle NN cord-015306-us58wwmp 3120 34 . . . cord-015306-us58wwmp 3121 1 About about RB cord-015306-us58wwmp 3121 2 60 60 CD cord-015306-us58wwmp 3121 3 % % NN cord-015306-us58wwmp 3121 4 of of IN cord-015306-us58wwmp 3121 5 the the DT cord-015306-us58wwmp 3121 6 children child NNS cord-015306-us58wwmp 3121 7 had have VBD cord-015306-us58wwmp 3121 8 RACHS-1 RACHS-1 NNP cord-015306-us58wwmp 3121 9 1 1 CD cord-015306-us58wwmp 3121 10 or or CC cord-015306-us58wwmp 3121 11 2 2 CD cord-015306-us58wwmp 3121 12 interventions intervention NNS cord-015306-us58wwmp 3121 13 . . . cord-015306-us58wwmp 3122 1 CS CS NNP cord-015306-us58wwmp 3122 2 - - HYPH cord-015306-us58wwmp 3122 3 AKI AKI NNP cord-015306-us58wwmp 3122 4 occurred occur VBD cord-015306-us58wwmp 3122 5 in in IN cord-015306-us58wwmp 3122 6 39 39 CD cord-015306-us58wwmp 3122 7 children child NNS cord-015306-us58wwmp 3122 8 ( ( -LRB- cord-015306-us58wwmp 3122 9 12.1 12.1 CD cord-015306-us58wwmp 3122 10 % % NN cord-015306-us58wwmp 3122 11 ) ) -RRB- cord-015306-us58wwmp 3122 12 , , , cord-015306-us58wwmp 3122 13 most most RBS cord-015306-us58wwmp 3122 14 often often RB cord-015306-us58wwmp 3122 15 in in IN cord-015306-us58wwmp 3122 16 the the DT cord-015306-us58wwmp 3122 17 first first JJ cord-015306-us58wwmp 3122 18 48 48 CD cord-015306-us58wwmp 3122 19 hours hour NNS cord-015306-us58wwmp 3122 20 after after IN cord-015306-us58wwmp 3122 21 cardiac cardiac JJ cord-015306-us58wwmp 3122 22 surgery surgery NN cord-015306-us58wwmp 3122 23 . . . cord-015306-us58wwmp 3123 1 On on IN cord-015306-us58wwmp 3123 2 univariate univariate JJ cord-015306-us58wwmp 3123 3 analysis analysis NN cord-015306-us58wwmp 3123 4 CS cs NN cord-015306-us58wwmp 3123 5 - - HYPH cord-015306-us58wwmp 3123 6 AKI AKI NNP cord-015306-us58wwmp 3123 7 was be VBD cord-015306-us58wwmp 3123 8 associated associate VBN cord-015306-us58wwmp 3123 9 with with IN cord-015306-us58wwmp 3123 10 sepsis sepsis NN cord-015306-us58wwmp 3123 11 and and CC cord-015306-us58wwmp 3123 12 intra intra JJ cord-015306-us58wwmp 3123 13 and and CC cord-015306-us58wwmp 3123 14 post post JJ cord-015306-us58wwmp 3123 15 - - JJ cord-015306-us58wwmp 3123 16 operative operative JJ cord-015306-us58wwmp 3123 17 hypotension hypotension NN cord-015306-us58wwmp 3123 18 . . . cord-015306-us58wwmp 3124 1 In in IN cord-015306-us58wwmp 3124 2 - - HYPH cord-015306-us58wwmp 3124 3 hospital hospital NN cord-015306-us58wwmp 3124 4 mortality mortality NN cord-015306-us58wwmp 3124 5 was be VBD cord-015306-us58wwmp 3124 6 6-fold 6-fold CD cord-015306-us58wwmp 3124 7 higher high JJR cord-015306-us58wwmp 3124 8 in in IN cord-015306-us58wwmp 3124 9 children child NNS cord-015306-us58wwmp 3124 10 who who WP cord-015306-us58wwmp 3124 11 developed develop VBD cord-015306-us58wwmp 3124 12 CS CS NNP cord-015306-us58wwmp 3124 13 - - HYPH cord-015306-us58wwmp 3124 14 AKI AKI NNP cord-015306-us58wwmp 3124 15 . . . cord-015306-us58wwmp 3125 1 CS CS NNP cord-015306-us58wwmp 3125 2 - - HYPH cord-015306-us58wwmp 3125 3 AKI AKI NNP cord-015306-us58wwmp 3125 4 was be VBD cord-015306-us58wwmp 3125 5 associated associate VBN cord-015306-us58wwmp 3125 6 with with IN cord-015306-us58wwmp 3125 7 2 2 CD cord-015306-us58wwmp 3125 8 - - SYM cord-015306-us58wwmp 3125 9 3 3 CD cord-015306-us58wwmp 3125 10 days day NNS cord-015306-us58wwmp 3125 11 longer long JJR cord-015306-us58wwmp 3125 12 duration duration NN cord-015306-us58wwmp 3125 13 of of IN cord-015306-us58wwmp 3125 14 mechanical mechanical JJ cord-015306-us58wwmp 3125 15 ventilation ventilation NN cord-015306-us58wwmp 3125 16 , , , cord-015306-us58wwmp 3125 17 inotropic inotropic NNP cord-015306-us58wwmp 3125 18 support support NN cord-015306-us58wwmp 3125 19 and and CC cord-015306-us58wwmp 3125 20 ICU ICU NNP cord-015306-us58wwmp 3125 21 stay stay VBP cord-015306-us58wwmp 3125 22 . . . cord-015306-us58wwmp 3126 1 Conclusion conclusion NN cord-015306-us58wwmp 3126 2 : : : cord-015306-us58wwmp 3127 1 CS CS NNP cord-015306-us58wwmp 3127 2 - - HYPH cord-015306-us58wwmp 3127 3 AKI AKI NNP cord-015306-us58wwmp 3127 4 occurs occur VBZ cord-015306-us58wwmp 3127 5 in in IN cord-015306-us58wwmp 3127 6 children child NNS cord-015306-us58wwmp 3127 7 in in IN cord-015306-us58wwmp 3127 8 developing develop VBG cord-015306-us58wwmp 3127 9 countries country NNS cord-015306-us58wwmp 3127 10 but but CC cord-015306-us58wwmp 3127 11 at at IN cord-015306-us58wwmp 3127 12 a a DT cord-015306-us58wwmp 3127 13 lower low JJR cord-015306-us58wwmp 3127 14 frequency frequency NN cord-015306-us58wwmp 3127 15 mainly mainly RB cord-015306-us58wwmp 3127 16 due due JJ cord-015306-us58wwmp 3127 17 to to IN cord-015306-us58wwmp 3127 18 older old JJR cord-015306-us58wwmp 3127 19 children child NNS cord-015306-us58wwmp 3127 20 with with IN cord-015306-us58wwmp 3127 21 less less RBR cord-015306-us58wwmp 3127 22 complex complex JJ cord-015306-us58wwmp 3127 23 congenital congenital JJ cord-015306-us58wwmp 3127 24 heart heart NN cord-015306-us58wwmp 3127 25 disease disease NN cord-015306-us58wwmp 3127 26 undergoing undergo VBG cord-015306-us58wwmp 3127 27 cardiac cardiac JJ cord-015306-us58wwmp 3127 28 surgery surgery NN cord-015306-us58wwmp 3127 29 . . . cord-015306-us58wwmp 3128 1 CS CS NNP cord-015306-us58wwmp 3128 2 - - HYPH cord-015306-us58wwmp 3128 3 AKI AKI NNP cord-015306-us58wwmp 3128 4 was be VBD cord-015306-us58wwmp 3128 5 associated associate VBN cord-015306-us58wwmp 3128 6 with with IN cord-015306-us58wwmp 3128 7 higher high JJR cord-015306-us58wwmp 3128 8 in in IN cord-015306-us58wwmp 3128 9 - - HYPH cord-015306-us58wwmp 3128 10 hospital hospital NN cord-015306-us58wwmp 3128 11 mortality mortality NN cord-015306-us58wwmp 3128 12 and and CC cord-015306-us58wwmp 3128 13 increased increase VBN cord-015306-us58wwmp 3128 14 utilization utilization NN cord-015306-us58wwmp 3128 15 of of IN cord-015306-us58wwmp 3128 16 hospital hospital NN cord-015306-us58wwmp 3128 17 services service NNS cord-015306-us58wwmp 3128 18 . . . cord-015306-us58wwmp 3129 1 Factors factor NNS cord-015306-us58wwmp 3129 2 associated associate VBN cord-015306-us58wwmp 3129 3 with with IN cord-015306-us58wwmp 3129 4 CS CS NNP cord-015306-us58wwmp 3129 5 - - HYPH cord-015306-us58wwmp 3129 6 AKI AKI NNP cord-015306-us58wwmp 3129 7 included include VBD cord-015306-us58wwmp 3129 8 intra intra JJ cord-015306-us58wwmp 3129 9 and and CC cord-015306-us58wwmp 3129 10 post post JJ cord-015306-us58wwmp 3129 11 - - JJ cord-015306-us58wwmp 3129 12 operative operative JJ cord-015306-us58wwmp 3129 13 hypotension hypotension NN cord-015306-us58wwmp 3129 14 and and CC cord-015306-us58wwmp 3129 15 sepsis sepsis NN cord-015306-us58wwmp 3129 16 . . . cord-015306-us58wwmp 3130 1 Objective objective NN cord-015306-us58wwmp 3130 2 : : : cord-015306-us58wwmp 3131 1 Data datum NNS cord-015306-us58wwmp 3131 2 on on IN cord-015306-us58wwmp 3131 3 long long JJ cord-015306-us58wwmp 3131 4 term term NN cord-015306-us58wwmp 3131 5 effects effect NNS cord-015306-us58wwmp 3131 6 of of IN cord-015306-us58wwmp 3131 7 newborns newborn NNS cord-015306-us58wwmp 3131 8 after after IN cord-015306-us58wwmp 3131 9 acute acute JJ cord-015306-us58wwmp 3131 10 kidney kidney NN cord-015306-us58wwmp 3131 11 injury injury NN cord-015306-us58wwmp 3131 12 is be VBZ cord-015306-us58wwmp 3131 13 limited limit VBN cord-015306-us58wwmp 3131 14 . . . cord-015306-us58wwmp 3132 1 The the DT cord-015306-us58wwmp 3132 2 aim aim NN cord-015306-us58wwmp 3132 3 of of IN cord-015306-us58wwmp 3132 4 the the DT cord-015306-us58wwmp 3132 5 study study NN cord-015306-us58wwmp 3132 6 was be VBD cord-015306-us58wwmp 3132 7 to to TO cord-015306-us58wwmp 3132 8 evaluate evaluate VB cord-015306-us58wwmp 3132 9 long long JJ cord-015306-us58wwmp 3132 10 term term NN cord-015306-us58wwmp 3132 11 effects effect NNS cord-015306-us58wwmp 3132 12 of of IN cord-015306-us58wwmp 3132 13 acute acute JJ cord-015306-us58wwmp 3132 14 kidney kidney NN cord-015306-us58wwmp 3132 15 injury injury NN cord-015306-us58wwmp 3132 16 ( ( -LRB- cord-015306-us58wwmp 3132 17 AKI AKI NNP cord-015306-us58wwmp 3132 18 ) ) -RRB- cord-015306-us58wwmp 3132 19 in in IN cord-015306-us58wwmp 3132 20 neonatal neonatal JJ cord-015306-us58wwmp 3132 21 period period NN cord-015306-us58wwmp 3132 22 . . . cord-015306-us58wwmp 3133 1 Methods method NNS cord-015306-us58wwmp 3133 2 : : : cord-015306-us58wwmp 3134 1 Inclusion inclusion NN cord-015306-us58wwmp 3134 2 criteria criterion NNS cord-015306-us58wwmp 3134 3 were be VBD cord-015306-us58wwmp 3134 4 as as IN cord-015306-us58wwmp 3134 5 follows follow VBZ cord-015306-us58wwmp 3134 6 : : : cord-015306-us58wwmp 3134 7 oligo oligo NNP cord-015306-us58wwmp 3134 8 - - HYPH cord-015306-us58wwmp 3134 9 anuria anuria NNP cord-015306-us58wwmp 3134 10 or or CC cord-015306-us58wwmp 3134 11 plasma plasma NN cord-015306-us58wwmp 3134 12 creatinine creatinine NN cord-015306-us58wwmp 3134 13 > > XX cord-015306-us58wwmp 3135 1 1.5 1.5 CD cord-015306-us58wwmp 3135 2 mg mg NNP cord-015306-us58wwmp 3135 3 / / SYM cord-015306-us58wwmp 3135 4 dl dl NN cord-015306-us58wwmp 3135 5 during during IN cord-015306-us58wwmp 3135 6 first first JJ cord-015306-us58wwmp 3135 7 three three CD cord-015306-us58wwmp 3135 8 postnatal postnatal JJ cord-015306-us58wwmp 3135 9 days day NNS cord-015306-us58wwmp 3135 10 or or CC cord-015306-us58wwmp 3135 11 > > XX cord-015306-us58wwmp 3135 12 0.7 0.7 CD cord-015306-us58wwmp 3135 13 mg mg NNP cord-015306-us58wwmp 3135 14 / / SYM cord-015306-us58wwmp 3135 15 dl dl NN cord-015306-us58wwmp 3135 16 after after IN cord-015306-us58wwmp 3135 17 third third JJ cord-015306-us58wwmp 3135 18 postnatal postnatal JJ cord-015306-us58wwmp 3135 19 day day NN cord-015306-us58wwmp 3135 20 or or CC cord-015306-us58wwmp 3135 21 ≥25 ≥25 NNP cord-015306-us58wwmp 3135 22 % % NN cord-015306-us58wwmp 3135 23 increase increase NN cord-015306-us58wwmp 3135 24 in in IN cord-015306-us58wwmp 3135 25 plasma plasma NN cord-015306-us58wwmp 3135 26 creatinine creatinine NN cord-015306-us58wwmp 3135 27 within within IN cord-015306-us58wwmp 3135 28 48 48 CD cord-015306-us58wwmp 3135 29 hours hour NNS cord-015306-us58wwmp 3135 30 during during IN cord-015306-us58wwmp 3135 31 hospitalization hospitalization NN cord-015306-us58wwmp 3135 32 in in IN cord-015306-us58wwmp 3135 33 neonatal neonatal JJ cord-015306-us58wwmp 3135 34 period period NN cord-015306-us58wwmp 3135 35 . . . cord-015306-us58wwmp 3136 1 Three three CD cord-015306-us58wwmp 3136 2 hundred hundred CD cord-015306-us58wwmp 3136 3 sixty sixty CD cord-015306-us58wwmp 3136 4 children child NNS cord-015306-us58wwmp 3136 5 who who WP cord-015306-us58wwmp 3136 6 had have VBD cord-015306-us58wwmp 3136 7 AKI AKI NNP cord-015306-us58wwmp 3136 8 during during IN cord-015306-us58wwmp 3136 9 neonatal neonatal JJ cord-015306-us58wwmp 3136 10 period period NN cord-015306-us58wwmp 3136 11 ( ( -LRB- cord-015306-us58wwmp 3136 12 between between IN cord-015306-us58wwmp 3136 13 January January NNP cord-015306-us58wwmp 3136 14 2000 2000 CD cord-015306-us58wwmp 3136 15 and and CC cord-015306-us58wwmp 3136 16 December December NNP cord-015306-us58wwmp 3136 17 2009 2009 CD cord-015306-us58wwmp 3136 18 ) ) -RRB- cord-015306-us58wwmp 3136 19 and and CC cord-015306-us58wwmp 3136 20 survived survive VBD cord-015306-us58wwmp 3136 21 to to IN cord-015306-us58wwmp 3136 22 hospital hospital NN cord-015306-us58wwmp 3136 23 discharge discharge NN cord-015306-us58wwmp 3136 24 were be VBD cord-015306-us58wwmp 3136 25 invited invite VBN cord-015306-us58wwmp 3136 26 ; ; : cord-015306-us58wwmp 3136 27 106 106 CD cord-015306-us58wwmp 3136 28 of of IN cord-015306-us58wwmp 3136 29 them -PRON- PRP cord-015306-us58wwmp 3136 30 accepted accept VBD cord-015306-us58wwmp 3136 31 to to TO cord-015306-us58wwmp 3136 32 participate participate VB cord-015306-us58wwmp 3136 33 . . . cord-015306-us58wwmp 3137 1 Patients patient NNS cord-015306-us58wwmp 3137 2 ' ' POS cord-015306-us58wwmp 3137 3 characteristics characteristic NNS cord-015306-us58wwmp 3137 4 during during IN cord-015306-us58wwmp 3137 5 AKI AKI NNP cord-015306-us58wwmp 3137 6 and and CC cord-015306-us58wwmp 3137 7 during during IN cord-015306-us58wwmp 3137 8 follow follow NN cord-015306-us58wwmp 3137 9 - - HYPH cord-015306-us58wwmp 3137 10 up up NN cord-015306-us58wwmp 3137 11 were be VBD cord-015306-us58wwmp 3137 12 recorded record VBN cord-015306-us58wwmp 3137 13 ; ; : cord-015306-us58wwmp 3137 14 a a DT cord-015306-us58wwmp 3137 15 physical physical JJ cord-015306-us58wwmp 3137 16 examination examination NN cord-015306-us58wwmp 3137 17 and and CC cord-015306-us58wwmp 3137 18 laboratory laboratory NN cord-015306-us58wwmp 3137 19 studies study NNS cord-015306-us58wwmp 3137 20 , , , cord-015306-us58wwmp 3137 21 including include VBG cord-015306-us58wwmp 3137 22 ACR ACR NNP cord-015306-us58wwmp 3137 23 ( ( -LRB- cord-015306-us58wwmp 3137 24 urine urine NN cord-015306-us58wwmp 3137 25 microalbumin microalbumin NNP cord-015306-us58wwmp 3137 26 / / SYM cord-015306-us58wwmp 3137 27 creatinine creatinine NN cord-015306-us58wwmp 3137 28 ratio ratio NN cord-015306-us58wwmp 3137 29 ) ) -RRB- cord-015306-us58wwmp 3137 30 were be VBD cord-015306-us58wwmp 3137 31 performed perform VBN cord-015306-us58wwmp 3137 32 . . . cord-015306-us58wwmp 3138 1 Schwartz Schwartz NNP cord-015306-us58wwmp 3138 2 formula formula NN cord-015306-us58wwmp 3138 3 was be VBD cord-015306-us58wwmp 3138 4 used use VBN cord-015306-us58wwmp 3138 5 to to TO cord-015306-us58wwmp 3138 6 estimate estimate VB cord-015306-us58wwmp 3138 7 GFR GFR NNP cord-015306-us58wwmp 3138 8 ; ; : cord-015306-us58wwmp 3138 9 hyperfiltration hyperfiltration NN cord-015306-us58wwmp 3138 10 was be VBD cord-015306-us58wwmp 3138 11 defined define VBN cord-015306-us58wwmp 3138 12 as as IN cord-015306-us58wwmp 3138 13 a a DT cord-015306-us58wwmp 3138 14 GFR GFR NNP cord-015306-us58wwmp 3139 1 > > XX cord-015306-us58wwmp 3140 1 160 160 CD cord-015306-us58wwmp 3140 2 ml/ ml/ XX cord-015306-us58wwmp 3141 1 min/1.73 min/1.73 NNP cord-015306-us58wwmp 3141 2 m m CD cord-015306-us58wwmp 3141 3 2 2 CD cord-015306-us58wwmp 3141 4 . . . cord-015306-us58wwmp 3142 1 Hypertension hypertension NN cord-015306-us58wwmp 3142 2 was be VBD cord-015306-us58wwmp 3142 3 defined define VBN cord-015306-us58wwmp 3142 4 as as IN cord-015306-us58wwmp 3142 5 blood blood NN cord-015306-us58wwmp 3142 6 pressure pressure NN cord-015306-us58wwmp 3142 7 ≥95 ≥95 NN cord-015306-us58wwmp 3142 8 th th XX cord-015306-us58wwmp 3142 9 percentile percentile NN cord-015306-us58wwmp 3142 10 for for IN cord-015306-us58wwmp 3142 11 age age NN cord-015306-us58wwmp 3142 12 , , , cord-015306-us58wwmp 3142 13 gender gender NN cord-015306-us58wwmp 3142 14 and and CC cord-015306-us58wwmp 3142 15 length length NN cord-015306-us58wwmp 3142 16 . . . cord-015306-us58wwmp 3143 1 Results result NNS cord-015306-us58wwmp 3143 2 : : : cord-015306-us58wwmp 3144 1 The the DT cord-015306-us58wwmp 3144 2 mean mean JJ cord-015306-us58wwmp 3144 3 age age NN cord-015306-us58wwmp 3144 4 on on IN cord-015306-us58wwmp 3144 5 evaluation evaluation NN cord-015306-us58wwmp 3144 6 was be VBD cord-015306-us58wwmp 3144 7 6.78±2.9 6.78±2.9 NNP cord-015306-us58wwmp 3144 8 years year NNS cord-015306-us58wwmp 3144 9 . . . cord-015306-us58wwmp 3145 1 15.8 15.8 CD cord-015306-us58wwmp 3145 2 - - HYPH cord-015306-us58wwmp 3145 3 15.8 15.8 CD cord-015306-us58wwmp 3145 4 - - SYM cord-015306-us58wwmp 3145 5 12 12 CD cord-015306-us58wwmp 3145 6 .2 .2 CD cord-015306-us58wwmp 3145 7 % % NN cord-015306-us58wwmp 3145 8 of of IN cord-015306-us58wwmp 3145 9 patients patient NNS cord-015306-us58wwmp 3145 10 . . . cord-015306-us58wwmp 3146 1 All all PDT cord-015306-us58wwmp 3146 2 these these DT cord-015306-us58wwmp 3146 3 children child NNS cord-015306-us58wwmp 3146 4 were be VBD cord-015306-us58wwmp 3146 5 dialyzed dialyze VBN cord-015306-us58wwmp 3146 6 for for IN cord-015306-us58wwmp 3146 7 more more JJR cord-015306-us58wwmp 3146 8 than than IN cord-015306-us58wwmp 3146 9 7 7 CD cord-015306-us58wwmp 3146 10 days day NNS cord-015306-us58wwmp 3146 11 on on IN cord-015306-us58wwmp 3146 12 acute acute JJ cord-015306-us58wwmp 3146 13 phase phase NN cord-015306-us58wwmp 3146 14 of of IN cord-015306-us58wwmp 3146 15 the the DT cord-015306-us58wwmp 3146 16 disease disease NN cord-015306-us58wwmp 3146 17 . . . cord-015306-us58wwmp 3147 1 At at IN cord-015306-us58wwmp 3147 2 time time NN cord-015306-us58wwmp 3147 3 of of IN cord-015306-us58wwmp 3147 4 discharge discharge NN cord-015306-us58wwmp 3147 5 from from IN cord-015306-us58wwmp 3147 6 hospital hospital NN cord-015306-us58wwmp 3147 7 proteinuria proteinuria NN cord-015306-us58wwmp 3147 8 remained remain VBD cord-015306-us58wwmp 3147 9 in in IN cord-015306-us58wwmp 3147 10 53 53 CD cord-015306-us58wwmp 3147 11 ( ( -LRB- cord-015306-us58wwmp 3147 12 85.5 85.5 CD cord-015306-us58wwmp 3147 13 % % NN cord-015306-us58wwmp 3147 14 ) ) -RRB- cord-015306-us58wwmp 3147 15 , , , cord-015306-us58wwmp 3147 16 hypertension hypertension NN cord-015306-us58wwmp 3147 17 -in -in IN cord-015306-us58wwmp 3147 18 47 47 CD cord-015306-us58wwmp 3147 19 ( ( -LRB- cord-015306-us58wwmp 3147 20 75.8 75.8 CD cord-015306-us58wwmp 3147 21 % % NN cord-015306-us58wwmp 3147 22 ) ) -RRB- cord-015306-us58wwmp 3147 23 patients patient NNS cord-015306-us58wwmp 3147 24 . . . cord-015306-us58wwmp 3148 1 After after IN cord-015306-us58wwmp 3148 2 1 1 CD cord-015306-us58wwmp 3148 3 year year NN cord-015306-us58wwmp 3148 4 , , , cord-015306-us58wwmp 3148 5 5years 5years CD cord-015306-us58wwmp 3148 6 and and CC cord-015306-us58wwmp 3148 7 > > XX cord-015306-us58wwmp 3148 8 10 10 CD cord-015306-us58wwmp 3148 9 years year NNS cord-015306-us58wwmp 3148 10 period period NN cord-015306-us58wwmp 3148 11 proteinuria proteinuria NN cord-015306-us58wwmp 3148 12 was be VBD cord-015306-us58wwmp 3148 13 detected detect VBN cord-015306-us58wwmp 3148 14 accordingly accordingly RB cord-015306-us58wwmp 3148 15 to to IN cord-015306-us58wwmp 3148 16 26.3 26.3 CD cord-015306-us58wwmp 3148 17 - - HYPH cord-015306-us58wwmp 3148 18 7.9 7.9 CD cord-015306-us58wwmp 3148 19 - - HYPH cord-015306-us58wwmp 3148 20 33.3 33.3 CD cord-015306-us58wwmp 3148 21 % % NN cord-015306-us58wwmp 3148 22 , , , cord-015306-us58wwmp 3148 23 hypertension hypertension NN cord-015306-us58wwmp 3148 24 to to IN cord-015306-us58wwmp 3148 25 11.3 11.3 CD cord-015306-us58wwmp 3148 26 - - SYM cord-015306-us58wwmp 3148 27 6.5 6.5 CD cord-015306-us58wwmp 3148 28 - - HYPH cord-015306-us58wwmp 3148 29 12.9 12.9 CD cord-015306-us58wwmp 3148 30 % % NN cord-015306-us58wwmp 3148 31 of of IN cord-015306-us58wwmp 3148 32 patients patient NNS cord-015306-us58wwmp 3148 33 . . . cord-015306-us58wwmp 3149 1 After after IN cord-015306-us58wwmp 3149 2 > > XX cord-015306-us58wwmp 3149 3 10 10 CD cord-015306-us58wwmp 3149 4 years year NNS cord-015306-us58wwmp 3149 5 from from IN cord-015306-us58wwmp 3149 6 the the DT cord-015306-us58wwmp 3149 7 onset onset NN cord-015306-us58wwmp 3149 8 of of IN cord-015306-us58wwmp 3149 9 disease disease NN cord-015306-us58wwmp 3149 10 hypertension hypertension NN cord-015306-us58wwmp 3149 11 was be VBD cord-015306-us58wwmp 3149 12 detected detect VBN cord-015306-us58wwmp 3149 13 more more RBR cord-015306-us58wwmp 3149 14 often often RB cord-015306-us58wwmp 3149 15 in in IN cord-015306-us58wwmp 3149 16 the the DT cord-015306-us58wwmp 3149 17 group group NN cord-015306-us58wwmp 3149 18 of of IN cord-015306-us58wwmp 3149 19 children child NNS cord-015306-us58wwmp 3149 20 who who WP cord-015306-us58wwmp 3149 21 were be VBD cord-015306-us58wwmp 3149 22 < < XX cord-015306-us58wwmp 3149 23 1 1 CD cord-015306-us58wwmp 3149 24 years year NNS cord-015306-us58wwmp 3149 25 old old JJ cord-015306-us58wwmp 3149 26 on on IN cord-015306-us58wwmp 3149 27 acute acute JJ cord-015306-us58wwmp 3149 28 phase phase NN cord-015306-us58wwmp 3149 29 of of IN cord-015306-us58wwmp 3149 30 the the DT cord-015306-us58wwmp 3149 31 disease disease NN cord-015306-us58wwmp 3149 32 ( ( -LRB- cord-015306-us58wwmp 3149 33 40 40 CD cord-015306-us58wwmp 3149 34 % % NN cord-015306-us58wwmp 3149 35 vs vs IN cord-015306-us58wwmp 3149 36 11.1 11.1 CD cord-015306-us58wwmp 3149 37 % % NN cord-015306-us58wwmp 3149 38 , , , cord-015306-us58wwmp 3149 39 p=0.05 p=0.05 NNP cord-015306-us58wwmp 3149 40 ) ) -RRB- cord-015306-us58wwmp 3149 41 . . . cord-015306-us58wwmp 3150 1 In in IN cord-015306-us58wwmp 3150 2 the the DT cord-015306-us58wwmp 3150 3 group group NN cord-015306-us58wwmp 3150 4 of of IN cord-015306-us58wwmp 3150 5 patients patient NNS cord-015306-us58wwmp 3150 6 who who WP cord-015306-us58wwmp 3150 7 had have VBD cord-015306-us58wwmp 3150 8 n't not RB cord-015306-us58wwmp 3150 9 proteinuria proteinuria NN cord-015306-us58wwmp 3150 10 on on IN cord-015306-us58wwmp 3150 11 the the DT cord-015306-us58wwmp 3150 12 acute acute JJ cord-015306-us58wwmp 3150 13 phase phase NN cord-015306-us58wwmp 3150 14 , , , cord-015306-us58wwmp 3150 15 after after IN cord-015306-us58wwmp 3150 16 > > XX cord-015306-us58wwmp 3150 17 10 10 CD cord-015306-us58wwmp 3150 18 years year NNS cord-015306-us58wwmp 3150 19 period period NN cord-015306-us58wwmp 3150 20 proteinuria proteinuria NN cord-015306-us58wwmp 3150 21 was be VBD cord-015306-us58wwmp 3150 22 observed observe VBN cord-015306-us58wwmp 3150 23 to to IN cord-015306-us58wwmp 3150 24 25 25 CD cord-015306-us58wwmp 3150 25 % % NN cord-015306-us58wwmp 3150 26 of of IN cord-015306-us58wwmp 3150 27 them -PRON- PRP cord-015306-us58wwmp 3150 28 . . . cord-015306-us58wwmp 3151 1 After after IN cord-015306-us58wwmp 3151 2 1 1 CD cord-015306-us58wwmp 3151 3 year year NN cord-015306-us58wwmp 3151 4 period period NN cord-015306-us58wwmp 3151 5 renal renal JJ cord-015306-us58wwmp 3151 6 impairment impairment NN cord-015306-us58wwmp 3151 7 of of IN cord-015306-us58wwmp 3151 8 various various JJ cord-015306-us58wwmp 3151 9 degree degree NN cord-015306-us58wwmp 3151 10 was be VBD cord-015306-us58wwmp 3151 11 observed observe VBN cord-015306-us58wwmp 3151 12 to to IN cord-015306-us58wwmp 3151 13 26.3 26.3 CD cord-015306-us58wwmp 3151 14 % % NN cord-015306-us58wwmp 3151 15 , , , cord-015306-us58wwmp 3151 16 after after IN cord-015306-us58wwmp 3151 17 5 5 CD cord-015306-us58wwmp 3151 18 years year NNS cord-015306-us58wwmp 3151 19 -to -to CD cord-015306-us58wwmp 3151 20 39.5 39.5 CD cord-015306-us58wwmp 3151 21 % % NN cord-015306-us58wwmp 3151 22 , , , cord-015306-us58wwmp 3151 23 after after IN cord-015306-us58wwmp 3151 24 > > XX cord-015306-us58wwmp 3151 25 10 10 CD cord-015306-us58wwmp 3151 26 years year NNS cord-015306-us58wwmp 3151 27 - - : cord-015306-us58wwmp 3151 28 to to IN cord-015306-us58wwmp 3151 29 33 33 CD cord-015306-us58wwmp 3151 30 . . . cord-015306-us58wwmp 3151 31 . . . cord-015306-us58wwmp 3152 1 On on IN cord-015306-us58wwmp 3152 2 admission admission NN cord-015306-us58wwmp 3152 3 his -PRON- PRP$ cord-015306-us58wwmp 3152 4 mean mean JJ cord-015306-us58wwmp 3152 5 arterial arterial JJ cord-015306-us58wwmp 3152 6 pressure pressure NN cord-015306-us58wwmp 3152 7 was be VBD cord-015306-us58wwmp 3152 8 35 35 CD cord-015306-us58wwmp 3152 9 mmHg mmHg NNS cord-015306-us58wwmp 3152 10 , , , cord-015306-us58wwmp 3152 11 his -PRON- PRP$ cord-015306-us58wwmp 3152 12 creatinine creatinine NN cord-015306-us58wwmp 3152 13 was be VBD cord-015306-us58wwmp 3152 14 5.8 5.8 CD cord-015306-us58wwmp 3152 15 , , , cord-015306-us58wwmp 3152 16 potassium potassium NN cord-015306-us58wwmp 3152 17 6.5 6.5 CD cord-015306-us58wwmp 3152 18 and and CC cord-015306-us58wwmp 3152 19 sodium sodium NN cord-015306-us58wwmp 3152 20 121 121 CD cord-015306-us58wwmp 3152 21 . . . cord-015306-us58wwmp 3153 1 Usual usual JJ cord-015306-us58wwmp 3153 2 medical medical JJ cord-015306-us58wwmp 3153 3 management management NN cord-015306-us58wwmp 3153 4 for for IN cord-015306-us58wwmp 3153 5 AKI AKI NNP cord-015306-us58wwmp 3153 6 was be VBD cord-015306-us58wwmp 3153 7 initiated initiate VBN cord-015306-us58wwmp 3153 8 but but CC cord-015306-us58wwmp 3153 9 even even RB cord-015306-us58wwmp 3153 10 by by IN cord-015306-us58wwmp 3153 11 late late JJ cord-015306-us58wwmp 3153 12 D5 D5 NNP cord-015306-us58wwmp 3153 13 he -PRON- PRP cord-015306-us58wwmp 3153 14 continued continue VBD cord-015306-us58wwmp 3153 15 to to TO cord-015306-us58wwmp 3153 16 be be VB cord-015306-us58wwmp 3153 17 anuric anuric JJ cord-015306-us58wwmp 3153 18 with with IN cord-015306-us58wwmp 3153 19 a a DT cord-015306-us58wwmp 3153 20 rising rise VBG cord-015306-us58wwmp 3153 21 creatinine creatinine NN cord-015306-us58wwmp 3153 22 . . . cord-015306-us58wwmp 3154 1 His -PRON- PRP$ cord-015306-us58wwmp 3154 2 uric uric NN cord-015306-us58wwmp 3154 3 acid acid NN cord-015306-us58wwmp 3154 4 was be VBD cord-015306-us58wwmp 3154 5 grossly grossly RB cord-015306-us58wwmp 3154 6 elevated elevate VBN cord-015306-us58wwmp 3154 7 at at IN cord-015306-us58wwmp 3154 8 14 14 CD cord-015306-us58wwmp 3154 9 mg mg NNP cord-015306-us58wwmp 3154 10 / / SYM cord-015306-us58wwmp 3154 11 dl dl NN cord-015306-us58wwmp 3154 12 . . . cord-015306-us58wwmp 3155 1 Dialysis dialysis NN cord-015306-us58wwmp 3155 2 was be VBD cord-015306-us58wwmp 3155 3 considered consider VBN cord-015306-us58wwmp 3155 4 but but CC cord-015306-us58wwmp 3155 5 as as IN cord-015306-us58wwmp 3155 6 the the DT cord-015306-us58wwmp 3155 7 parents parent NNS cord-015306-us58wwmp 3155 8 were be VBD cord-015306-us58wwmp 3155 9 not not RB cord-015306-us58wwmp 3155 10 in in IN cord-015306-us58wwmp 3155 11 favour favour NN cord-015306-us58wwmp 3155 12 of of IN cord-015306-us58wwmp 3155 13 it -PRON- PRP cord-015306-us58wwmp 3155 14 they -PRON- PRP cord-015306-us58wwmp 3155 15 were be VBD cord-015306-us58wwmp 3155 16 offered offer VBN cord-015306-us58wwmp 3155 17 the the DT cord-015306-us58wwmp 3155 18 option option NN cord-015306-us58wwmp 3155 19 of of IN cord-015306-us58wwmp 3155 20 rasburicase rasburicase NNP cord-015306-us58wwmp 3155 21 . . . cord-015306-us58wwmp 3156 1 Rasburicase Rasburicase NNP cord-015306-us58wwmp 3156 2 was be VBD cord-015306-us58wwmp 3156 3 given give VBN cord-015306-us58wwmp 3156 4 on on IN cord-015306-us58wwmp 3156 5 late late JJ cord-015306-us58wwmp 3156 6 D5 d5 NN cord-015306-us58wwmp 3156 7 and and CC cord-015306-us58wwmp 3156 8 within within IN cord-015306-us58wwmp 3156 9 12 12 CD cord-015306-us58wwmp 3156 10 hrs hrs NN cord-015306-us58wwmp 3156 11 he -PRON- PRP cord-015306-us58wwmp 3156 12 started start VBD cord-015306-us58wwmp 3156 13 to to TO cord-015306-us58wwmp 3156 14 produce produce VB cord-015306-us58wwmp 3156 15 urine urine NN cord-015306-us58wwmp 3156 16 which which WDT cord-015306-us58wwmp 3156 17 peaked peak VBD cord-015306-us58wwmp 3156 18 at at IN cord-015306-us58wwmp 3156 19 4 4 CD cord-015306-us58wwmp 3156 20 ml ml NN cord-015306-us58wwmp 3156 21 / / SYM cord-015306-us58wwmp 3156 22 kg kg NN cord-015306-us58wwmp 3156 23 / / SYM cord-015306-us58wwmp 3156 24 hr hr NN cord-015306-us58wwmp 3156 25 by by IN cord-015306-us58wwmp 3156 26 D9 D9 NNP cord-015306-us58wwmp 3156 27 . . . cord-015306-us58wwmp 3157 1 The the DT cord-015306-us58wwmp 3157 2 creatinine creatinine NN cord-015306-us58wwmp 3157 3 also also RB cord-015306-us58wwmp 3157 4 showed show VBD cord-015306-us58wwmp 3157 5 a a DT cord-015306-us58wwmp 3157 6 concomitant concomitant JJ cord-015306-us58wwmp 3157 7 fall fall NN cord-015306-us58wwmp 3157 8 and and CC cord-015306-us58wwmp 3157 9 by by IN cord-015306-us58wwmp 3157 10 discharge discharge NN cord-015306-us58wwmp 3157 11 ( ( -LRB- cord-015306-us58wwmp 3157 12 D10 D10 NNP cord-015306-us58wwmp 3157 13 ) ) -RRB- cord-015306-us58wwmp 3157 14 it -PRON- PRP cord-015306-us58wwmp 3157 15 was be VBD cord-015306-us58wwmp 3157 16 2.1 2.1 CD cord-015306-us58wwmp 3157 17 mg mg NNP cord-015306-us58wwmp 3157 18 / / SYM cord-015306-us58wwmp 3157 19 dl dl NNP cord-015306-us58wwmp 3157 20 and and CC cord-015306-us58wwmp 3157 21 normalized normalize VBD cord-015306-us58wwmp 3157 22 at at IN cord-015306-us58wwmp 3157 23 0.5 0.5 CD cord-015306-us58wwmp 3157 24 mg mg NNP cord-015306-us58wwmp 3157 25 / / SYM cord-015306-us58wwmp 3157 26 dl dl NN cord-015306-us58wwmp 3157 27 by by IN cord-015306-us58wwmp 3157 28 D30 D30 NNP cord-015306-us58wwmp 3157 29 . . . cord-015306-us58wwmp 3158 1 Uric uric NN cord-015306-us58wwmp 3158 2 acid acid NN cord-015306-us58wwmp 3158 3 was be VBD cord-015306-us58wwmp 3158 4 0.5 0.5 CD cord-015306-us58wwmp 3158 5 mg mg NNP cord-015306-us58wwmp 3158 6 / / SYM cord-015306-us58wwmp 3158 7 dl dl NNP cord-015306-us58wwmp 3158 8 on on IN cord-015306-us58wwmp 3158 9 D7 D7 NNP cord-015306-us58wwmp 3158 10 and and CC cord-015306-us58wwmp 3158 11 2.8 2.8 CD cord-015306-us58wwmp 3158 12 mg mg NNP cord-015306-us58wwmp 3158 13 / / SYM cord-015306-us58wwmp 3158 14 dl dl NNP cord-015306-us58wwmp 3158 15 on on IN cord-015306-us58wwmp 3158 16 D9 D9 NNP cord-015306-us58wwmp 3158 17 . . . cord-015306-us58wwmp 3159 1 Case case NN cord-015306-us58wwmp 3159 2 2 2 CD cord-015306-us58wwmp 3159 3 : : SYM cord-015306-us58wwmp 3159 4 6 6 CD cord-015306-us58wwmp 3159 5 years year NNS cord-015306-us58wwmp 3159 6 old old JJ cord-015306-us58wwmp 3159 7 boy boy NN cord-015306-us58wwmp 3159 8 with with IN cord-015306-us58wwmp 3159 9 multiple multiple JJ cord-015306-us58wwmp 3159 10 special special JJ cord-015306-us58wwmp 3159 11 needs need NNS cord-015306-us58wwmp 3159 12 was be VBD cord-015306-us58wwmp 3159 13 transferred transfer VBN cord-015306-us58wwmp 3159 14 from from IN cord-015306-us58wwmp 3159 15 another another DT cord-015306-us58wwmp 3159 16 hospital hospital NN cord-015306-us58wwmp 3159 17 intubated intubate VBN cord-015306-us58wwmp 3159 18 , , , cord-015306-us58wwmp 3159 19 anuric anuric JJ cord-015306-us58wwmp 3159 20 and and CC cord-015306-us58wwmp 3159 21 in in IN cord-015306-us58wwmp 3159 22 multi multi JJ cord-015306-us58wwmp 3159 23 organ organ NN cord-015306-us58wwmp 3159 24 failure failure NN cord-015306-us58wwmp 3159 25 ( ( -LRB- cord-015306-us58wwmp 3159 26 MOF MOF NNP cord-015306-us58wwmp 3159 27 ) ) -RRB- cord-015306-us58wwmp 3159 28 . . . cord-015306-us58wwmp 3160 1 Creatinine creatinine NN cord-015306-us58wwmp 3160 2 was be VBD cord-015306-us58wwmp 3160 3 elevated elevate VBN cord-015306-us58wwmp 3160 4 at at IN cord-015306-us58wwmp 3160 5 3.7 3.7 CD cord-015306-us58wwmp 3160 6 mg mg NNP cord-015306-us58wwmp 3160 7 / / SYM cord-015306-us58wwmp 3160 8 dl dl NN cord-015306-us58wwmp 3160 9 and and CC cord-015306-us58wwmp 3160 10 uric uric NN cord-015306-us58wwmp 3160 11 acid acid NN cord-015306-us58wwmp 3160 12 was be VBD cord-015306-us58wwmp 3160 13 also also RB cord-015306-us58wwmp 3160 14 found find VBN cord-015306-us58wwmp 3160 15 to to TO cord-015306-us58wwmp 3160 16 be be VB cord-015306-us58wwmp 3160 17 raised raise VBN cord-015306-us58wwmp 3160 18 at at IN cord-015306-us58wwmp 3160 19 9.1 9.1 CD cord-015306-us58wwmp 3160 20 mg mg NNP cord-015306-us58wwmp 3160 21 / / SYM cord-015306-us58wwmp 3160 22 dl dl NN cord-015306-us58wwmp 3160 23 . . . cord-015306-us58wwmp 3161 1 In in IN cord-015306-us58wwmp 3161 2 view view NN cord-015306-us58wwmp 3161 3 of of IN cord-015306-us58wwmp 3161 4 MOF MOF NNP cord-015306-us58wwmp 3161 5 along along IN cord-015306-us58wwmp 3161 6 with with IN cord-015306-us58wwmp 3161 7 Disseminated disseminate VBN cord-015306-us58wwmp 3161 8 Intravascular Intravascular NNP cord-015306-us58wwmp 3161 9 Coagulopathy Coagulopathy NNP cord-015306-us58wwmp 3161 10 ( ( -LRB- cord-015306-us58wwmp 3161 11 DIC DIC NNP cord-015306-us58wwmp 3161 12 ) ) -RRB- cord-015306-us58wwmp 3161 13 dialysis dialysis NN cord-015306-us58wwmp 3161 14 was be VBD cord-015306-us58wwmp 3161 15 considered consider VBN cord-015306-us58wwmp 3161 16 a a DT cord-015306-us58wwmp 3161 17 risky risky JJ cord-015306-us58wwmp 3161 18 process process NN cord-015306-us58wwmp 3161 19 and and CC cord-015306-us58wwmp 3161 20 parents parent NNS cord-015306-us58wwmp 3161 21 were be VBD cord-015306-us58wwmp 3161 22 offered offer VBN cord-015306-us58wwmp 3161 23 the the DT cord-015306-us58wwmp 3161 24 option option NN cord-015306-us58wwmp 3161 25 of of IN cord-015306-us58wwmp 3161 26 rasburicase rasburicase NNP cord-015306-us58wwmp 3161 27 . . . cord-015306-us58wwmp 3162 1 Rasburicase Rasburicase NNP cord-015306-us58wwmp 3162 2 was be VBD cord-015306-us58wwmp 3162 3 given give VBN cord-015306-us58wwmp 3162 4 on on IN cord-015306-us58wwmp 3162 5 D2 d2 NN cord-015306-us58wwmp 3162 6 of of IN cord-015306-us58wwmp 3162 7 admission admission NN cord-015306-us58wwmp 3162 8 and and CC cord-015306-us58wwmp 3162 9 although although IN cord-015306-us58wwmp 3162 10 the the DT cord-015306-us58wwmp 3162 11 repeat repeat NN cord-015306-us58wwmp 3162 12 uric uric NN cord-015306-us58wwmp 3162 13 acid acid NN cord-015306-us58wwmp 3162 14 was be VBD cord-015306-us58wwmp 3162 15 0.3 0.3 CD cord-015306-us58wwmp 3162 16 mg mg NNP cord-015306-us58wwmp 3162 17 / / SYM cord-015306-us58wwmp 3162 18 dl dl NN cord-015306-us58wwmp 3163 1 and and CC cord-015306-us58wwmp 3163 2 he -PRON- PRP cord-015306-us58wwmp 3163 3 did do VBD cord-015306-us58wwmp 3163 4 produce produce VB cord-015306-us58wwmp 3163 5 5 5 CD cord-015306-us58wwmp 3163 6 ml ml NNS cord-015306-us58wwmp 3163 7 of of IN cord-015306-us58wwmp 3163 8 urine urine NN cord-015306-us58wwmp 3163 9 within within IN cord-015306-us58wwmp 3163 10 6 6 CD cord-015306-us58wwmp 3163 11 hours hour NNS cord-015306-us58wwmp 3164 1 no no DT cord-015306-us58wwmp 3164 2 further further JJ cord-015306-us58wwmp 3164 3 improvement improvement NN cord-015306-us58wwmp 3164 4 in in IN cord-015306-us58wwmp 3164 5 renal renal JJ cord-015306-us58wwmp 3164 6 parameters parameter NNS cord-015306-us58wwmp 3164 7 was be VBD cord-015306-us58wwmp 3164 8 noticed notice VBN cord-015306-us58wwmp 3164 9 . . . cord-015306-us58wwmp 3165 1 Dialysis dialysis NN cord-015306-us58wwmp 3165 2 ( ( -LRB- cord-015306-us58wwmp 3165 3 SLED SLED NNP cord-015306-us58wwmp 3165 4 ) ) -RRB- cord-015306-us58wwmp 3165 5 was be VBD cord-015306-us58wwmp 3165 6 initiated initiate VBN cord-015306-us58wwmp 3165 7 on on IN cord-015306-us58wwmp 3165 8 D3 D3 NNP cord-015306-us58wwmp 3165 9 . . . cord-015306-us58wwmp 3166 1 Although although IN cord-015306-us58wwmp 3166 2 the the DT cord-015306-us58wwmp 3166 3 creatinine creatinine NN cord-015306-us58wwmp 3166 4 improved improve VBD cord-015306-us58wwmp 3166 5 with with IN cord-015306-us58wwmp 3166 6 SLED SLED NNP cord-015306-us58wwmp 3166 7 he -PRON- PRP cord-015306-us58wwmp 3166 8 continued continue VBD cord-015306-us58wwmp 3166 9 to to TO cord-015306-us58wwmp 3166 10 be be VB cord-015306-us58wwmp 3166 11 oligo oligo NN cord-015306-us58wwmp 3166 12 - - HYPH cord-015306-us58wwmp 3166 13 anuric anuric JJ cord-015306-us58wwmp 3166 14 and and CC cord-015306-us58wwmp 3166 15 died die VBD cord-015306-us58wwmp 3166 16 of of IN cord-015306-us58wwmp 3166 17 MOF MOF NNP cord-015306-us58wwmp 3166 18 by by IN cord-015306-us58wwmp 3166 19 D5 D5 NNP cord-015306-us58wwmp 3166 20 . . . cord-015306-us58wwmp 3167 1 Conclusion conclusion NN cord-015306-us58wwmp 3167 2 : : : cord-015306-us58wwmp 3168 1 Although although IN cord-015306-us58wwmp 3168 2 Rasburicase Rasburicase NNP cord-015306-us58wwmp 3168 3 seemed seem VBD cord-015306-us58wwmp 3168 4 to to TO cord-015306-us58wwmp 3168 5 work work VB cord-015306-us58wwmp 3168 6 in in IN cord-015306-us58wwmp 3168 7 case1 case1 NN cord-015306-us58wwmp 3168 8 , , , cord-015306-us58wwmp 3168 9 it -PRON- PRP cord-015306-us58wwmp 3168 10 was be VBD cord-015306-us58wwmp 3168 11 not not RB cord-015306-us58wwmp 3168 12 beneficial beneficial JJ cord-015306-us58wwmp 3168 13 in in IN cord-015306-us58wwmp 3168 14 Case case NN cord-015306-us58wwmp 3168 15 2 2 CD cord-015306-us58wwmp 3168 16 . . . cord-015306-us58wwmp 3169 1 The the DT cord-015306-us58wwmp 3169 2 exact exact JJ cord-015306-us58wwmp 3169 3 mechanism mechanism NN cord-015306-us58wwmp 3169 4 for for IN cord-015306-us58wwmp 3169 5 rasburicase rasburicase NNP cord-015306-us58wwmp 3169 6 is be VBZ cord-015306-us58wwmp 3169 7 still still RB cord-015306-us58wwmp 3169 8 hypothetical hypothetical JJ cord-015306-us58wwmp 3169 9 and and CC cord-015306-us58wwmp 3169 10 the the DT cord-015306-us58wwmp 3169 11 few few JJ cord-015306-us58wwmp 3169 12 case case NN cord-015306-us58wwmp 3169 13 reports report NNS cord-015306-us58wwmp 3169 14 have have VBP cord-015306-us58wwmp 3169 15 all all DT cord-015306-us58wwmp 3169 16 documented document VBN cord-015306-us58wwmp 3169 17 positive positive JJ cord-015306-us58wwmp 3169 18 results result NNS cord-015306-us58wwmp 3169 19 . . . cord-015306-us58wwmp 3170 1 Although although IN cord-015306-us58wwmp 3170 2 it -PRON- PRP cord-015306-us58wwmp 3170 3 seemed seem VBD cord-015306-us58wwmp 3170 4 to to TO cord-015306-us58wwmp 3170 5 have have VB cord-015306-us58wwmp 3170 6 worked work VBN cord-015306-us58wwmp 3170 7 in in IN cord-015306-us58wwmp 3170 8 Case case NN cord-015306-us58wwmp 3170 9 1 1 CD cord-015306-us58wwmp 3170 10 , , , cord-015306-us58wwmp 3170 11 to to IN cord-015306-us58wwmp 3170 12 the the DT cord-015306-us58wwmp 3170 13 best good JJS cord-015306-us58wwmp 3170 14 of of IN cord-015306-us58wwmp 3170 15 our -PRON- PRP$ cord-015306-us58wwmp 3170 16 knowledge knowledge NN cord-015306-us58wwmp 3170 17 case case NN cord-015306-us58wwmp 3170 18 2 2 CD cord-015306-us58wwmp 3170 19 is be VBZ cord-015306-us58wwmp 3170 20 the the DT cord-015306-us58wwmp 3170 21 first first JJ cord-015306-us58wwmp 3170 22 documented document VBN cord-015306-us58wwmp 3170 23 case case NN cord-015306-us58wwmp 3170 24 wherein wherein WRB cord-015306-us58wwmp 3170 25 it -PRON- PRP cord-015306-us58wwmp 3170 26 did do VBD cord-015306-us58wwmp 3170 27 not not RB cord-015306-us58wwmp 3170 28 work work VB cord-015306-us58wwmp 3170 29 . . . cord-015306-us58wwmp 3171 1 Proper proper JJ cord-015306-us58wwmp 3171 2 randomized randomized JJ cord-015306-us58wwmp 3171 3 control control NN cord-015306-us58wwmp 3171 4 trial trial NN cord-015306-us58wwmp 3171 5 is be VBZ cord-015306-us58wwmp 3171 6 needed need VBN cord-015306-us58wwmp 3171 7 before before IN cord-015306-us58wwmp 3171 8 advocating advocate VBG cord-015306-us58wwmp 3171 9 rasburicase rasburicase NNP cord-015306-us58wwmp 3171 10 as as IN cord-015306-us58wwmp 3171 11 a a DT cord-015306-us58wwmp 3171 12 novel novel JJ cord-015306-us58wwmp 3171 13 therapy therapy NN cord-015306-us58wwmp 3171 14 for for IN cord-015306-us58wwmp 3171 15 AKI AKI NNP cord-015306-us58wwmp 3171 16 . . . cord-015306-us58wwmp 3172 1 Results result NNS cord-015306-us58wwmp 3172 2 : : : cord-015306-us58wwmp 3173 1 Age age NN cord-015306-us58wwmp 3173 2 , , , cord-015306-us58wwmp 3173 3 sex sex NN cord-015306-us58wwmp 3173 4 , , , cord-015306-us58wwmp 3173 5 diagnosis diagnosis NN cord-015306-us58wwmp 3173 6 , , , cord-015306-us58wwmp 3173 7 baseline baseline NN cord-015306-us58wwmp 3173 8 and and CC cord-015306-us58wwmp 3173 9 post post JJ cord-015306-us58wwmp 3173 10 - - JJ cord-015306-us58wwmp 3173 11 surgery surgery JJ cord-015306-us58wwmp 3173 12 hemoglobin hemoglobin NN cord-015306-us58wwmp 3173 13 , , , cord-015306-us58wwmp 3173 14 total total JJ cord-015306-us58wwmp 3173 15 leukocyte leukocyte NN cord-015306-us58wwmp 3173 16 count count NN cord-015306-us58wwmp 3173 17 , , , cord-015306-us58wwmp 3173 18 platelet platelet NN cord-015306-us58wwmp 3173 19 count count NN cord-015306-us58wwmp 3173 20 and and CC cord-015306-us58wwmp 3173 21 biochemistry biochemistry NN cord-015306-us58wwmp 3173 22 were be VBD cord-015306-us58wwmp 3173 23 recorded record VBN cord-015306-us58wwmp 3173 24 . . . cord-015306-us58wwmp 3174 1 Baseline baseline JJ cord-015306-us58wwmp 3174 2 and and CC cord-015306-us58wwmp 3174 3 post post JJ cord-015306-us58wwmp 3174 4 - - JJ cord-015306-us58wwmp 3174 5 operative operative JJ cord-015306-us58wwmp 3174 6 , , , cord-015306-us58wwmp 3174 7 urea urea NN cord-015306-us58wwmp 3174 8 ( ( -LRB- cord-015306-us58wwmp 3174 9 mg mg NNP cord-015306-us58wwmp 3174 10 / / SYM cord-015306-us58wwmp 3174 11 dl dl NNP cord-015306-us58wwmp 3174 12 ) ) -RRB- cord-015306-us58wwmp 3174 13 , , , cord-015306-us58wwmp 3174 14 creatinine creatinine NNP cord-015306-us58wwmp 3174 15 ( ( -LRB- cord-015306-us58wwmp 3174 16 mg mg NNP cord-015306-us58wwmp 3174 17 / / SYM cord-015306-us58wwmp 3174 18 dl dl NNP cord-015306-us58wwmp 3174 19 ) ) -RRB- cord-015306-us58wwmp 3174 20 , , , cord-015306-us58wwmp 3174 21 urine urine NN cord-015306-us58wwmp 3174 22 output output NN cord-015306-us58wwmp 3174 23 ( ( -LRB- cord-015306-us58wwmp 3174 24 ml ml NN cord-015306-us58wwmp 3174 25 / / SYM cord-015306-us58wwmp 3174 26 kg kg NNP cord-015306-us58wwmp 3174 27 / / SYM cord-015306-us58wwmp 3174 28 hr hr NN cord-015306-us58wwmp 3174 29 ) ) -RRB- cord-015306-us58wwmp 3174 30 and and CC cord-015306-us58wwmp 3174 31 inotrope inotrope NN cord-015306-us58wwmp 3174 32 dose dose NN cord-015306-us58wwmp 3174 33 were be VBD cord-015306-us58wwmp 3174 34 also also RB cord-015306-us58wwmp 3174 35 recorded record VBN cord-015306-us58wwmp 3174 36 daily daily RB cord-015306-us58wwmp 3174 37 . . . cord-015306-us58wwmp 3175 1 The the DT cord-015306-us58wwmp 3175 2 duration duration NN cord-015306-us58wwmp 3175 3 of of IN cord-015306-us58wwmp 3175 4 CPB CPB NNP cord-015306-us58wwmp 3175 5 was be VBD cord-015306-us58wwmp 3175 6 noted note VBN cord-015306-us58wwmp 3175 7 . . . cord-015306-us58wwmp 3176 1 Post post VB cord-015306-us58wwmp 3176 2 - - JJ cord-015306-us58wwmp 3176 3 operatively operatively RB cord-015306-us58wwmp 3176 4 cardiac cardiac JJ cord-015306-us58wwmp 3176 5 , , , cord-015306-us58wwmp 3176 6 renal renal JJ cord-015306-us58wwmp 3176 7 , , , cord-015306-us58wwmp 3176 8 hepatic hepatic JJ cord-015306-us58wwmp 3176 9 , , , cord-015306-us58wwmp 3176 10 neurological neurological JJ cord-015306-us58wwmp 3176 11 and and CC cord-015306-us58wwmp 3176 12 respiratory respiratory JJ cord-015306-us58wwmp 3176 13 dysfunctions dysfunction NNS cord-015306-us58wwmp 3176 14 were be VBD cord-015306-us58wwmp 3176 15 recorded record VBN cord-015306-us58wwmp 3176 16 . . . cord-015306-us58wwmp 3177 1 Conclusion conclusion NN cord-015306-us58wwmp 3177 2 : : : cord-015306-us58wwmp 3177 3 Fifteen fifteen CD cord-015306-us58wwmp 3177 4 ( ( -LRB- cord-015306-us58wwmp 3177 5 7.2 7.2 CD cord-015306-us58wwmp 3177 6 % % NN cord-015306-us58wwmp 3177 7 ) ) -RRB- cord-015306-us58wwmp 3177 8 children child NNS cord-015306-us58wwmp 3177 9 developed develop VBD cord-015306-us58wwmp 3177 10 AKI AKI NNP cord-015306-us58wwmp 3177 11 stage stage NN cord-015306-us58wwmp 3178 1 I -PRON- PRP cord-015306-us58wwmp 3178 2 , , , cord-015306-us58wwmp 3178 3 one one CD cord-015306-us58wwmp 3178 4 child child NN cord-015306-us58wwmp 3178 5 ( ( -LRB- cord-015306-us58wwmp 3178 6 0.5 0.5 CD cord-015306-us58wwmp 3178 7 % % NN cord-015306-us58wwmp 3178 8 ) ) -RRB- cord-015306-us58wwmp 3178 9 developed develop VBD cord-015306-us58wwmp 3178 10 AKI AKI NNP cord-015306-us58wwmp 3178 11 stage stage NN cord-015306-us58wwmp 3178 12 II II NNP cord-015306-us58wwmp 3178 13 and and CC cord-015306-us58wwmp 3178 14 four four CD cord-015306-us58wwmp 3178 15 children child NNS cord-015306-us58wwmp 3179 1 developed develop VBD cord-015306-us58wwmp 3179 2 AKI AKI NNP cord-015306-us58wwmp 3179 3 stage stage NN cord-015306-us58wwmp 3179 4 III III NNP cord-015306-us58wwmp 3179 5 ( ( -LRB- cord-015306-us58wwmp 3179 6 2 2 CD cord-015306-us58wwmp 3179 7 % % NN cord-015306-us58wwmp 3179 8 ) ) -RRB- cord-015306-us58wwmp 3179 9 . . . cord-015306-us58wwmp 3180 1 All all DT cord-015306-us58wwmp 3180 2 patients patient NNS cord-015306-us58wwmp 3180 3 with with IN cord-015306-us58wwmp 3180 4 AKI AKI NNP cord-015306-us58wwmp 3180 5 had have VBD cord-015306-us58wwmp 3180 6 a a DT cord-015306-us58wwmp 3180 7 longer long RBR cord-015306-us58wwmp 3180 8 stay stay NN cord-015306-us58wwmp 3180 9 in in IN cord-015306-us58wwmp 3180 10 hospital hospital NN cord-015306-us58wwmp 3180 11 . . . cord-015306-us58wwmp 3181 1 Eight eight CD cord-015306-us58wwmp 3181 2 children child NNS cord-015306-us58wwmp 3181 3 required require VBD cord-015306-us58wwmp 3181 4 dialysis dialysis NN cord-015306-us58wwmp 3181 5 for for IN cord-015306-us58wwmp 3181 6 AKI AKI NNP cord-015306-us58wwmp 3181 7 ; ; : cord-015306-us58wwmp 3181 8 two two CD cord-015306-us58wwmp 3181 9 required require VBN cord-015306-us58wwmp 3181 10 dialysis dialysis NN cord-015306-us58wwmp 3181 11 to to TO cord-015306-us58wwmp 3181 12 maintain maintain VB cord-015306-us58wwmp 3181 13 the the DT cord-015306-us58wwmp 3181 14 fluid fluid JJ cord-015306-us58wwmp 3181 15 balance balance NN cord-015306-us58wwmp 3181 16 post post NN cord-015306-us58wwmp 3181 17 operatively operatively RB cord-015306-us58wwmp 3181 18 . . . cord-015306-us58wwmp 3182 1 None none NN cord-015306-us58wwmp 3182 2 developed develop VBD cord-015306-us58wwmp 3182 3 chronic chronic JJ cord-015306-us58wwmp 3182 4 renal renal JJ cord-015306-us58wwmp 3182 5 impairment impairment NN cord-015306-us58wwmp 3182 6 . . . cord-015306-us58wwmp 3183 1 Using use VBG cord-015306-us58wwmp 3183 2 stepwise stepwise JJ cord-015306-us58wwmp 3183 3 regression regression NN cord-015306-us58wwmp 3183 4 , , , cord-015306-us58wwmp 3183 5 younger young JJR cord-015306-us58wwmp 3183 6 age age NN cord-015306-us58wwmp 3183 7 ( ( -LRB- cord-015306-us58wwmp 3183 8 < < NNP cord-015306-us58wwmp 3183 9 1 1 CD cord-015306-us58wwmp 3183 10 year year NN cord-015306-us58wwmp 3183 11 ) ) -RRB- cord-015306-us58wwmp 3183 12 , , , cord-015306-us58wwmp 3183 13 weight weight NN cord-015306-us58wwmp 3183 14 < < XX cord-015306-us58wwmp 3183 15 10Kg 10kg CD cord-015306-us58wwmp 3183 16 , , , cord-015306-us58wwmp 3183 17 pump pump NN cord-015306-us58wwmp 3183 18 failure failure NN cord-015306-us58wwmp 3183 19 , , , cord-015306-us58wwmp 3183 20 sepsis sepsis NN cord-015306-us58wwmp 3183 21 and and CC cord-015306-us58wwmp 3183 22 duration duration NN cord-015306-us58wwmp 3183 23 of of IN cord-015306-us58wwmp 3183 24 CPB CPB NNP cord-015306-us58wwmp 3183 25 more more JJR cord-015306-us58wwmp 3183 26 than than IN cord-015306-us58wwmp 3183 27 60 60 CD cord-015306-us58wwmp 3183 28 minutes minute NNS cord-015306-us58wwmp 3183 29 were be VBD cord-015306-us58wwmp 3183 30 significant significant JJ cord-015306-us58wwmp 3183 31 risk risk NN cord-015306-us58wwmp 3183 32 factor factor NN cord-015306-us58wwmp 3183 33 for for IN cord-015306-us58wwmp 3183 34 developing develop VBG cord-015306-us58wwmp 3183 35 AKI AKI NNP cord-015306-us58wwmp 3183 36 . . . cord-015306-us58wwmp 3184 1 Results result NNS cord-015306-us58wwmp 3184 2 : : : cord-015306-us58wwmp 3185 1 most most JJS cord-015306-us58wwmp 3185 2 of of IN cord-015306-us58wwmp 3185 3 the the DT cord-015306-us58wwmp 3185 4 patients patient NNS cord-015306-us58wwmp 3185 5 were be VBD cord-015306-us58wwmp 3185 6 male male JJ cord-015306-us58wwmp 3185 7 , , , cord-015306-us58wwmp 3185 8 with with IN cord-015306-us58wwmp 3185 9 less less JJR cord-015306-us58wwmp 3185 10 than than IN cord-015306-us58wwmp 3185 11 28 28 CD cord-015306-us58wwmp 3185 12 days day NNS cord-015306-us58wwmp 3185 13 old old JJ cord-015306-us58wwmp 3185 14 and and CC cord-015306-us58wwmp 3185 15 weighing weigh VBG cord-015306-us58wwmp 3185 16 less less JJR cord-015306-us58wwmp 3185 17 than than IN cord-015306-us58wwmp 3185 18 5 5 CD cord-015306-us58wwmp 3185 19 kg kg NNS cord-015306-us58wwmp 3185 20 . . . cord-015306-us58wwmp 3186 1 In in IN cord-015306-us58wwmp 3186 2 the the DT cord-015306-us58wwmp 3186 3 majority majority NN cord-015306-us58wwmp 3186 4 of of IN cord-015306-us58wwmp 3186 5 cases case NNS cord-015306-us58wwmp 3186 6 ( ( -LRB- cord-015306-us58wwmp 3186 7 77 77 CD cord-015306-us58wwmp 3186 8 % % NN cord-015306-us58wwmp 3186 9 ) ) -RRB- cord-015306-us58wwmp 3186 10 , , , cord-015306-us58wwmp 3186 11 ARF ARF NNP cord-015306-us58wwmp 3186 12 was be VBD cord-015306-us58wwmp 3186 13 diagnosed diagnose VBN cord-015306-us58wwmp 3186 14 in in IN cord-015306-us58wwmp 3186 15 the the DT cord-015306-us58wwmp 3186 16 first first JJ cord-015306-us58wwmp 3186 17 6 6 CD cord-015306-us58wwmp 3186 18 days day NNS cord-015306-us58wwmp 3186 19 after after IN cord-015306-us58wwmp 3186 20 surgery surgery NN cord-015306-us58wwmp 3186 21 , , , cord-015306-us58wwmp 3186 22 demonstrating demonstrate VBG cord-015306-us58wwmp 3186 23 influence influence NN cord-015306-us58wwmp 3186 24 of of IN cord-015306-us58wwmp 3186 25 the the DT cord-015306-us58wwmp 3186 26 procedure procedure NN cord-015306-us58wwmp 3186 27 itself -PRON- PRP cord-015306-us58wwmp 3186 28 . . . cord-015306-us58wwmp 3187 1 All all DT cord-015306-us58wwmp 3187 2 of of IN cord-015306-us58wwmp 3187 3 them -PRON- PRP cord-015306-us58wwmp 3187 4 were be VBD cord-015306-us58wwmp 3187 5 treated treat VBN cord-015306-us58wwmp 3187 6 by by IN cord-015306-us58wwmp 3187 7 peritoneal peritoneal NN cord-015306-us58wwmp 3187 8 dialysis(PD dialysis(PD NNS cord-015306-us58wwmp 3187 9 ) ) -RRB- cord-015306-us58wwmp 3187 10 for for IN cord-015306-us58wwmp 3187 11 a a DT cord-015306-us58wwmp 3187 12 mean mean JJ cord-015306-us58wwmp 3187 13 time time NN cord-015306-us58wwmp 3187 14 of of IN cord-015306-us58wwmp 3187 15 255 255 CD cord-015306-us58wwmp 3187 16 hours hour NNS cord-015306-us58wwmp 3187 17 ; ; : cord-015306-us58wwmp 3187 18 58.3 58.3 CD cord-015306-us58wwmp 3187 19 % % NN cord-015306-us58wwmp 3187 20 of of IN cord-015306-us58wwmp 3187 21 them -PRON- PRP cord-015306-us58wwmp 3187 22 died die VBD cord-015306-us58wwmp 3187 23 . . . cord-015306-us58wwmp 3188 1 There there EX cord-015306-us58wwmp 3188 2 was be VBD cord-015306-us58wwmp 3188 3 no no DT cord-015306-us58wwmp 3188 4 statistical statistical JJ cord-015306-us58wwmp 3188 5 significant significant JJ cord-015306-us58wwmp 3188 6 difference difference NN cord-015306-us58wwmp 3188 7 between between IN cord-015306-us58wwmp 3188 8 age age NN cord-015306-us58wwmp 3188 9 , , , cord-015306-us58wwmp 3188 10 time time NN cord-015306-us58wwmp 3188 11 on on IN cord-015306-us58wwmp 3188 12 extracorporeal extracorporeal JJ cord-015306-us58wwmp 3188 13 circulation circulation NN cord-015306-us58wwmp 3188 14 and and CC cord-015306-us58wwmp 3188 15 duration duration NN cord-015306-us58wwmp 3188 16 of of IN cord-015306-us58wwmp 3188 17 dialysis dialysis NN cord-015306-us58wwmp 3188 18 , , , cord-015306-us58wwmp 3188 19 comparing compare VBG cord-015306-us58wwmp 3188 20 the the DT cord-015306-us58wwmp 3188 21 patients patient NNS cord-015306-us58wwmp 3188 22 who who WP cord-015306-us58wwmp 3188 23 survived survive VBD cord-015306-us58wwmp 3188 24 and and CC cord-015306-us58wwmp 3188 25 the the DT cord-015306-us58wwmp 3188 26 deceased deceased JJ cord-015306-us58wwmp 3188 27 ones one NNS cord-015306-us58wwmp 3188 28 . . . cord-015306-us58wwmp 3189 1 Conclusion conclusion NN cord-015306-us58wwmp 3189 2 : : : cord-015306-us58wwmp 3190 1 Acute acute JJ cord-015306-us58wwmp 3190 2 renal renal JJ cord-015306-us58wwmp 3190 3 failure failure NN cord-015306-us58wwmp 3190 4 is be VBZ cord-015306-us58wwmp 3190 5 a a DT cord-015306-us58wwmp 3190 6 common common JJ cord-015306-us58wwmp 3190 7 complication complication NN cord-015306-us58wwmp 3190 8 in in IN cord-015306-us58wwmp 3190 9 children child NNS cord-015306-us58wwmp 3190 10 with with IN cord-015306-us58wwmp 3190 11 congenital congenital JJ cord-015306-us58wwmp 3190 12 heart heart NN cord-015306-us58wwmp 3190 13 disease disease NN cord-015306-us58wwmp 3190 14 and and CC cord-015306-us58wwmp 3190 15 PD PD NNP cord-015306-us58wwmp 3190 16 is be VBZ cord-015306-us58wwmp 3190 17 a a DT cord-015306-us58wwmp 3190 18 safe safe JJ cord-015306-us58wwmp 3190 19 dialytic dialytic JJ cord-015306-us58wwmp 3190 20 method method NN cord-015306-us58wwmp 3190 21 . . . cord-015306-us58wwmp 3191 1 The the DT cord-015306-us58wwmp 3191 2 mortality mortality NN cord-015306-us58wwmp 3191 3 rate rate NN cord-015306-us58wwmp 3191 4 is be VBZ cord-015306-us58wwmp 3191 5 high high JJ cord-015306-us58wwmp 3191 6 and and CC cord-015306-us58wwmp 3191 7 influenced influence VBN cord-015306-us58wwmp 3191 8 by by IN cord-015306-us58wwmp 3191 9 aspects aspect NNS cord-015306-us58wwmp 3191 10 related relate VBN cord-015306-us58wwmp 3191 11 to to IN cord-015306-us58wwmp 3191 12 the the DT cord-015306-us58wwmp 3191 13 child child NN cord-015306-us58wwmp 3191 14 , , , cord-015306-us58wwmp 3191 15 underlying underlie VBG cord-015306-us58wwmp 3191 16 disease disease NN cord-015306-us58wwmp 3191 17 , , , cord-015306-us58wwmp 3191 18 type type NN cord-015306-us58wwmp 3191 19 of of IN cord-015306-us58wwmp 3191 20 surgery surgery NN cord-015306-us58wwmp 3191 21 and and CC cord-015306-us58wwmp 3191 22 many many JJ cord-015306-us58wwmp 3191 23 other other JJ cord-015306-us58wwmp 3191 24 associated associate VBN cord-015306-us58wwmp 3191 25 aspects aspect NNS cord-015306-us58wwmp 3191 26 . . . cord-015306-us58wwmp 3192 1 Abstract abstract JJ cord-015306-us58wwmp 3192 2 # # NN cord-015306-us58wwmp 3192 3 P p NN cord-015306-us58wwmp 3192 4 - - HYPH cord-015306-us58wwmp 3192 5 SAT344 SAT344 NNP cord-015306-us58wwmp 3193 1 Acute acute JJ cord-015306-us58wwmp 3193 2 Kidney kidney NN cord-015306-us58wwmp 3193 3 Injury injury NN cord-015306-us58wwmp 3193 4 epidemiology epidemiology NN cord-015306-us58wwmp 3193 5 and and CC cord-015306-us58wwmp 3193 6 associated associate VBN cord-015306-us58wwmp 3193 7 factors factor NNS cord-015306-us58wwmp 3193 8 in in IN cord-015306-us58wwmp 3193 9 a a DT cord-015306-us58wwmp 3193 10 pediatric pediatric JJ cord-015306-us58wwmp 3193 11 intensive intensive JJ cord-015306-us58wwmp 3193 12 care care NN cord-015306-us58wwmp 3193 13 unit unit NN cord-015306-us58wwmp 3193 14 . . . cord-015306-us58wwmp 3194 1 Conclusion conclusion NN cord-015306-us58wwmp 3194 2 : : : cord-015306-us58wwmp 3195 1 Acute acute JJ cord-015306-us58wwmp 3195 2 kidney kidney NN cord-015306-us58wwmp 3195 3 injury injury NN cord-015306-us58wwmp 3195 4 ( ( -LRB- cord-015306-us58wwmp 3195 5 AKI AKI NNP cord-015306-us58wwmp 3195 6 ) ) -RRB- cord-015306-us58wwmp 3195 7 is be VBZ cord-015306-us58wwmp 3195 8 associated associate VBN cord-015306-us58wwmp 3195 9 with with IN cord-015306-us58wwmp 3195 10 significant significant JJ cord-015306-us58wwmp 3195 11 morbidity morbidity NN cord-015306-us58wwmp 3195 12 and and CC cord-015306-us58wwmp 3195 13 mortality mortality NN cord-015306-us58wwmp 3195 14 in in IN cord-015306-us58wwmp 3195 15 pediatric pediatric JJ cord-015306-us58wwmp 3195 16 patients patient NNS cord-015306-us58wwmp 3195 17 with with IN cord-015306-us58wwmp 3195 18 critical critical JJ cord-015306-us58wwmp 3195 19 illness illness NN cord-015306-us58wwmp 3195 20 . . . cord-015306-us58wwmp 3196 1 The the DT cord-015306-us58wwmp 3196 2 main main JJ cord-015306-us58wwmp 3196 3 causes cause NNS cord-015306-us58wwmp 3196 4 associated associate VBN cord-015306-us58wwmp 3196 5 to to IN cord-015306-us58wwmp 3196 6 AKI AKI NNP cord-015306-us58wwmp 3196 7 were be VBD cord-015306-us58wwmp 3196 8 sepsis sepsis NN cord-015306-us58wwmp 3196 9 and and CC cord-015306-us58wwmp 3196 10 shock shock NN cord-015306-us58wwmp 3196 11 . . . cord-015306-us58wwmp 3197 1 We -PRON- PRP cord-015306-us58wwmp 3197 2 found find VBD cord-015306-us58wwmp 3197 3 no no DT cord-015306-us58wwmp 3197 4 association association NN cord-015306-us58wwmp 3197 5 with with IN cord-015306-us58wwmp 3197 6 cardiac cardiac JJ cord-015306-us58wwmp 3197 7 surgery surgery NN cord-015306-us58wwmp 3197 8 , , , cord-015306-us58wwmp 3197 9 probably probably RB cord-015306-us58wwmp 3197 10 explained explain VBD cord-015306-us58wwmp 3197 11 by by IN cord-015306-us58wwmp 3197 12 the the DT cord-015306-us58wwmp 3197 13 low low JJ cord-015306-us58wwmp 3197 14 level level NN cord-015306-us58wwmp 3197 15 of of IN cord-015306-us58wwmp 3197 16 complexity complexity NN cord-015306-us58wwmp 3197 17 that that WDT cord-015306-us58wwmp 3197 18 is be VBZ cord-015306-us58wwmp 3197 19 performed perform VBN cord-015306-us58wwmp 3197 20 in in IN cord-015306-us58wwmp 3197 21 our -PRON- PRP$ cord-015306-us58wwmp 3197 22 center center NN cord-015306-us58wwmp 3197 23 . . . cord-015306-us58wwmp 3198 1 Almost almost RB cord-015306-us58wwmp 3198 2 half half NN cord-015306-us58wwmp 3198 3 of of IN cord-015306-us58wwmp 3198 4 our -PRON- PRP$ cord-015306-us58wwmp 3198 5 patients patient NNS cord-015306-us58wwmp 3198 6 with with IN cord-015306-us58wwmp 3198 7 AKI AKI NNP cord-015306-us58wwmp 3198 8 were be VBD cord-015306-us58wwmp 3198 9 in in IN cord-015306-us58wwmp 3198 10 Failure failure NN cord-015306-us58wwmp 3198 11 and and CC cord-015306-us58wwmp 3198 12 the the DT cord-015306-us58wwmp 3198 13 mortality mortality NN cord-015306-us58wwmp 3198 14 was be VBD cord-015306-us58wwmp 3198 15 high high JJ cord-015306-us58wwmp 3198 16 as as IN cord-015306-us58wwmp 3198 17 previously previously RB cord-015306-us58wwmp 3198 18 reported report VBN cord-015306-us58wwmp 3198 19 . . . cord-015306-us58wwmp 3199 1 Objective objective NN cord-015306-us58wwmp 3199 2 : : : cord-015306-us58wwmp 3200 1 Fibroblast fibroblast JJ cord-015306-us58wwmp 3200 2 growth growth NN cord-015306-us58wwmp 3201 1 factor-23 factor-23 LS cord-015306-us58wwmp 3201 2 ( ( -LRB- cord-015306-us58wwmp 3201 3 FGF-23 FGF-23 NNP cord-015306-us58wwmp 3201 4 ) ) -RRB- cord-015306-us58wwmp 3201 5 , , , cord-015306-us58wwmp 3201 6 a a DT cord-015306-us58wwmp 3201 7 phosphaturic phosphaturic JJ cord-015306-us58wwmp 3201 8 hormone hormone NN cord-015306-us58wwmp 3201 9 involved involve VBN cord-015306-us58wwmp 3201 10 in in IN cord-015306-us58wwmp 3201 11 calcium calcium NN cord-015306-us58wwmp 3201 12 phosphate phosphate NN cord-015306-us58wwmp 3201 13 homeostasis homeostasis NN cord-015306-us58wwmp 3201 14 , , , cord-015306-us58wwmp 3201 15 appears appear VBZ cord-015306-us58wwmp 3201 16 to to TO cord-015306-us58wwmp 3201 17 predict predict VB cord-015306-us58wwmp 3201 18 renal renal JJ cord-015306-us58wwmp 3201 19 disease disease NN cord-015306-us58wwmp 3201 20 progression progression NN cord-015306-us58wwmp 3201 21 in in IN cord-015306-us58wwmp 3201 22 adults adult NNS cord-015306-us58wwmp 3201 23 with with IN cord-015306-us58wwmp 3201 24 non non JJ cord-015306-us58wwmp 3201 25 - - JJ cord-015306-us58wwmp 3201 26 diabetic diabetic JJ cord-015306-us58wwmp 3201 27 CKD CKD NNP cord-015306-us58wwmp 3201 28 ( ( -LRB- cord-015306-us58wwmp 3201 29 Fliser Fliser NNP cord-015306-us58wwmp 3201 30 , , , cord-015306-us58wwmp 3201 31 JASN JASN NNP cord-015306-us58wwmp 3201 32 2007 2007 CD cord-015306-us58wwmp 3201 33 ) ) -RRB- cord-015306-us58wwmp 3201 34 . . . cord-015306-us58wwmp 3202 1 This this DT cord-015306-us58wwmp 3202 2 study study NN cord-015306-us58wwmp 3202 3 aimed aim VBD cord-015306-us58wwmp 3202 4 to to TO cord-015306-us58wwmp 3202 5 determine determine VB cord-015306-us58wwmp 3202 6 renal renal JJ cord-015306-us58wwmp 3202 7 survival survival NN cord-015306-us58wwmp 3202 8 according accord VBG cord-015306-us58wwmp 3202 9 to to IN cord-015306-us58wwmp 3202 10 FGF-23 FGF-23 NNP cord-015306-us58wwmp 3202 11 serum serum NN cord-015306-us58wwmp 3202 12 levels level NNS cord-015306-us58wwmp 3202 13 in in IN cord-015306-us58wwmp 3202 14 children child NNS cord-015306-us58wwmp 3202 15 with with IN cord-015306-us58wwmp 3202 16 CKD CKD NNP cord-015306-us58wwmp 3202 17 stage stage NN cord-015306-us58wwmp 3202 18 II II NNP cord-015306-us58wwmp 3202 19 - - HYPH cord-015306-us58wwmp 3202 20 IV IV NNP cord-015306-us58wwmp 3202 21 . . . cord-015306-us58wwmp 3203 1 Methods method NNS cord-015306-us58wwmp 3203 2 : : : cord-015306-us58wwmp 3203 3 232 232 CD cord-015306-us58wwmp 3203 4 children child NNS cord-015306-us58wwmp 3203 5 participating participate VBG cord-015306-us58wwmp 3203 6 in in IN cord-015306-us58wwmp 3203 7 the the DT cord-015306-us58wwmp 3203 8 ESCAPE ESCAPE NNP cord-015306-us58wwmp 3203 9 trial trial NN cord-015306-us58wwmp 3203 10 ( ( -LRB- cord-015306-us58wwmp 3203 11 age age NN cord-015306-us58wwmp 3203 12 11.5±4 11.5±4 CD cord-015306-us58wwmp 3203 13 yrs yr NNS cord-015306-us58wwmp 3203 14 , , , cord-015306-us58wwmp 3203 15 GFR GFR NNP cord-015306-us58wwmp 3203 16 45±18 45±18 NNP cord-015306-us58wwmp 3203 17 ml ml XX cord-015306-us58wwmp 3203 18 / / SYM cord-015306-us58wwmp 3203 19 min/1.73 min/1.73 JJ cord-015306-us58wwmp 3203 20 m m CD cord-015306-us58wwmp 3203 21 2 2 CD cord-015306-us58wwmp 3203 22 ; ; , cord-015306-us58wwmp 3203 23 underlying underlie VBG cord-015306-us58wwmp 3203 24 renal renal JJ cord-015306-us58wwmp 3203 25 disease disease NN cord-015306-us58wwmp 3203 26 : : : cord-015306-us58wwmp 3203 27 hypo hypo NN cord-015306-us58wwmp 3203 28 / / SYM cord-015306-us58wwmp 3203 29 dysplasia dysplasia NN cord-015306-us58wwmp 3203 30 ( ( -LRB- cord-015306-us58wwmp 3203 31 71 71 CD cord-015306-us58wwmp 3203 32 % % NN cord-015306-us58wwmp 3203 33 ) ) -RRB- cord-015306-us58wwmp 3203 34 , , , cord-015306-us58wwmp 3203 35 glomerulopathies glomerulopathie NNS cord-015306-us58wwmp 3203 36 ( ( -LRB- cord-015306-us58wwmp 3203 37 12 12 CD cord-015306-us58wwmp 3203 38 % % NN cord-015306-us58wwmp 3203 39 ) ) -RRB- cord-015306-us58wwmp 3203 40 , , , cord-015306-us58wwmp 3203 41 hereditary hereditary JJ cord-015306-us58wwmp 3203 42 or or CC cord-015306-us58wwmp 3203 43 other other JJ cord-015306-us58wwmp 3203 44 ( ( -LRB- cord-015306-us58wwmp 3203 45 17 17 CD cord-015306-us58wwmp 3203 46 % % NN cord-015306-us58wwmp 3203 47 ) ) -RRB- cord-015306-us58wwmp 3203 48 ) ) -RRB- cord-015306-us58wwmp 3203 49 were be VBD cord-015306-us58wwmp 3203 50 analyzed analyze VBN cord-015306-us58wwmp 3203 51 . . . cord-015306-us58wwmp 3204 1 All all DT cord-015306-us58wwmp 3204 2 patients patient NNS cord-015306-us58wwmp 3204 3 received receive VBD cord-015306-us58wwmp 3204 4 fixed fix VBN cord-015306-us58wwmp 3204 5 dose dose NN cord-015306-us58wwmp 3204 6 ACE ace NN cord-015306-us58wwmp 3204 7 inhibition inhibition NN cord-015306-us58wwmp 3204 8 and and CC cord-015306-us58wwmp 3204 9 were be VBD cord-015306-us58wwmp 3204 10 followed follow VBN cord-015306-us58wwmp 3204 11 prospectively prospectively RB cord-015306-us58wwmp 3204 12 by by IN cord-015306-us58wwmp 3204 13 2-monthly 2-monthly CD cord-015306-us58wwmp 3204 14 examinations examination NNS cord-015306-us58wwmp 3204 15 for for IN cord-015306-us58wwmp 3204 16 up up IN cord-015306-us58wwmp 3204 17 to to TO cord-015306-us58wwmp 3204 18 5 5 CD cord-015306-us58wwmp 3204 19 years year NNS cord-015306-us58wwmp 3204 20 . . . cord-015306-us58wwmp 3205 1 The the DT cord-015306-us58wwmp 3205 2 study study NN cord-015306-us58wwmp 3205 3 endpoint endpoint NN cord-015306-us58wwmp 3205 4 was be VBD cord-015306-us58wwmp 3205 5 defined define VBN cord-015306-us58wwmp 3205 6 by by IN cord-015306-us58wwmp 3205 7 eGFR egfr JJ cord-015306-us58wwmp 3205 8 loss loss NN cord-015306-us58wwmp 3205 9 > > XX cord-015306-us58wwmp 3205 10 50 50 CD cord-015306-us58wwmp 3205 11 % % NN cord-015306-us58wwmp 3205 12 from from IN cord-015306-us58wwmp 3205 13 baseline baseline NN cord-015306-us58wwmp 3205 14 , , , cord-015306-us58wwmp 3205 15 GFR GFR NNP cord-015306-us58wwmp 3205 16 < < XX cord-015306-us58wwmp 3205 17 10ml 10ml NN cord-015306-us58wwmp 3205 18 or or CC cord-015306-us58wwmp 3205 19 start start VB cord-015306-us58wwmp 3205 20 of of IN cord-015306-us58wwmp 3205 21 renal renal JJ cord-015306-us58wwmp 3205 22 replacement replacement NN cord-015306-us58wwmp 3205 23 therapy therapy NN cord-015306-us58wwmp 3205 24 . . . cord-015306-us58wwmp 3206 1 FGF-23 fgf-23 JJ cord-015306-us58wwmp 3206 2 levels level NNS cord-015306-us58wwmp 3206 3 were be VBD cord-015306-us58wwmp 3206 4 determined determine VBN cord-015306-us58wwmp 3206 5 at at IN cord-015306-us58wwmp 3206 6 baseline baseline NN cord-015306-us58wwmp 3206 7 ( ( -LRB- cord-015306-us58wwmp 3206 8 C c NN cord-015306-us58wwmp 3206 9 - - HYPH cord-015306-us58wwmp 3206 10 terminal terminal NN cord-015306-us58wwmp 3206 11 human human JJ cord-015306-us58wwmp 3206 12 FGF-23 FGF-23 NNP cord-015306-us58wwmp 3206 13 ELISA ELISA NNP cord-015306-us58wwmp 3206 14 ( ( -LRB- cord-015306-us58wwmp 3206 15 Immutopics Immutopics NNP cord-015306-us58wwmp 3206 16 , , , cord-015306-us58wwmp 3206 17 San San NNP cord-015306-us58wwmp 3206 18 Clemente Clemente NNP cord-015306-us58wwmp 3206 19 , , , cord-015306-us58wwmp 3206 20 CA CA NNP cord-015306-us58wwmp 3206 21 , , , cord-015306-us58wwmp 3206 22 USA USA NNP cord-015306-us58wwmp 3206 23 Objective Objective NNP cord-015306-us58wwmp 3206 24 : : : cord-015306-us58wwmp 3207 1 The the DT cord-015306-us58wwmp 3207 2 long long JJ cord-015306-us58wwmp 3207 3 - - HYPH cord-015306-us58wwmp 3207 4 term term NN cord-015306-us58wwmp 3207 5 outcome outcome NN cord-015306-us58wwmp 3207 6 of of IN cord-015306-us58wwmp 3207 7 patients patient NNS cord-015306-us58wwmp 3207 8 born bear VBN cord-015306-us58wwmp 3207 9 with with IN cord-015306-us58wwmp 3207 10 unilateral unilateral JJ cord-015306-us58wwmp 3207 11 renal renal JJ cord-015306-us58wwmp 3207 12 agenesis agenesis NN cord-015306-us58wwmp 3207 13 ( ( -LRB- cord-015306-us58wwmp 3207 14 URA URA NNP cord-015306-us58wwmp 3207 15 ) ) -RRB- cord-015306-us58wwmp 3207 16 and and CC cord-015306-us58wwmp 3207 17 of of IN cord-015306-us58wwmp 3207 18 those those DT cord-015306-us58wwmp 3207 19 who who WP cord-015306-us58wwmp 3207 20 underwent undergo VBD cord-015306-us58wwmp 3207 21 therapeutic therapeutic JJ cord-015306-us58wwmp 3207 22 unilateral unilateral JJ cord-015306-us58wwmp 3207 23 nephrectomy nephrectomy NN cord-015306-us58wwmp 3207 24 ( ( -LRB- cord-015306-us58wwmp 3207 25 UN UN NNP cord-015306-us58wwmp 3207 26 ) ) -RRB- cord-015306-us58wwmp 3207 27 remains remain VBZ cord-015306-us58wwmp 3207 28 a a DT cord-015306-us58wwmp 3207 29 topic topic NN cord-015306-us58wwmp 3207 30 of of IN cord-015306-us58wwmp 3207 31 concern concern NN cord-015306-us58wwmp 3207 32 and and CC cord-015306-us58wwmp 3207 33 debate debate NN cord-015306-us58wwmp 3207 34 . . . cord-015306-us58wwmp 3208 1 Children child NNS cord-015306-us58wwmp 3208 2 with with IN cord-015306-us58wwmp 3208 3 a a DT cord-015306-us58wwmp 3208 4 solitary solitary JJ cord-015306-us58wwmp 3208 5 functioning function VBG cord-015306-us58wwmp 3208 6 kidney kidney NN cord-015306-us58wwmp 3208 7 ( ( -LRB- cord-015306-us58wwmp 3208 8 SFK SFK NNP cord-015306-us58wwmp 3208 9 ) ) -RRB- cord-015306-us58wwmp 3208 10 have have VB cord-015306-us58wwmp 3208 11 an an DT cord-015306-us58wwmp 3208 12 increased increase VBN cord-015306-us58wwmp 3208 13 risk risk NN cord-015306-us58wwmp 3208 14 of of IN cord-015306-us58wwmp 3208 15 developing develop VBG cord-015306-us58wwmp 3208 16 hypertension hypertension NN cord-015306-us58wwmp 3208 17 , , , cord-015306-us58wwmp 3208 18 albuminuria albuminuria NNS cord-015306-us58wwmp 3208 19 and and CC cord-015306-us58wwmp 3208 20 chronic chronic JJ cord-015306-us58wwmp 3208 21 kidney kidney NN cord-015306-us58wwmp 3208 22 disease disease NN cord-015306-us58wwmp 3208 23 in in IN cord-015306-us58wwmp 3208 24 later later JJ cord-015306-us58wwmp 3208 25 life life NN cord-015306-us58wwmp 3208 26 . . . cord-015306-us58wwmp 3209 1 The the DT cord-015306-us58wwmp 3209 2 purpose purpose NN cord-015306-us58wwmp 3209 3 of of IN cord-015306-us58wwmp 3209 4 this this DT cord-015306-us58wwmp 3209 5 study study NN cord-015306-us58wwmp 3209 6 was be VBD cord-015306-us58wwmp 3209 7 to to TO cord-015306-us58wwmp 3209 8 identify identify VB cord-015306-us58wwmp 3209 9 whether whether IN cord-015306-us58wwmp 3209 10 plasma plasma NN cord-015306-us58wwmp 3209 11 symmetric symmetric JJ cord-015306-us58wwmp 3209 12 dimethylarginine dimethylarginine NN cord-015306-us58wwmp 3209 13 ( ( -LRB- cord-015306-us58wwmp 3209 14 pSDMA psdma NN cord-015306-us58wwmp 3209 15 ) ) -RRB- cord-015306-us58wwmp 3209 16 is be VBZ cord-015306-us58wwmp 3209 17 an an DT cord-015306-us58wwmp 3209 18 useful useful JJ cord-015306-us58wwmp 3209 19 biomarker biomarker NN cord-015306-us58wwmp 3209 20 reflecting reflect VBG cord-015306-us58wwmp 3209 21 the the DT cord-015306-us58wwmp 3209 22 level level NN cord-015306-us58wwmp 3209 23 of of IN cord-015306-us58wwmp 3209 24 renal renal JJ cord-015306-us58wwmp 3209 25 injury injury NN cord-015306-us58wwmp 3209 26 in in IN cord-015306-us58wwmp 3209 27 children child NNS cord-015306-us58wwmp 3209 28 with with IN cord-015306-us58wwmp 3209 29 solitary solitary JJ cord-015306-us58wwmp 3209 30 functioning function VBG cord-015306-us58wwmp 3209 31 kidney kidney NN cord-015306-us58wwmp 3209 32 ( ( -LRB- cord-015306-us58wwmp 3209 33 SFK SFK NNP cord-015306-us58wwmp 3209 34 ) ) -RRB- cord-015306-us58wwmp 3209 35 . . . cord-015306-us58wwmp 3210 1 Methods method NNS cord-015306-us58wwmp 3210 2 : : : cord-015306-us58wwmp 3211 1 We -PRON- PRP cord-015306-us58wwmp 3211 2 measured measure VBD cord-015306-us58wwmp 3211 3 circulating circulate VBG cord-015306-us58wwmp 3211 4 pSDMA psdma NN cord-015306-us58wwmp 3211 5 in in IN cord-015306-us58wwmp 3211 6 51 51 CD cord-015306-us58wwmp 3211 7 patients patient NNS cord-015306-us58wwmp 3211 8 with with IN cord-015306-us58wwmp 3211 9 SFK SFK NNP cord-015306-us58wwmp 3211 10 and and CC cord-015306-us58wwmp 3211 11 no no DT cord-015306-us58wwmp 3211 12 other other JJ cord-015306-us58wwmp 3211 13 urinary urinary JJ cord-015306-us58wwmp 3211 14 defects defect NNS cord-015306-us58wwmp 3211 15 . . . cord-015306-us58wwmp 3212 1 Patients patient NNS cord-015306-us58wwmp 3212 2 were be VBD cord-015306-us58wwmp 3212 3 subdivided subdivide VBN cord-015306-us58wwmp 3212 4 for for IN cord-015306-us58wwmp 3212 5 two two CD cord-015306-us58wwmp 3212 6 groups group NNS cord-015306-us58wwmp 3212 7 : : : cord-015306-us58wwmp 3212 8 primary primary JJ cord-015306-us58wwmp 3212 9 SFK SFK NNP cord-015306-us58wwmp 3212 10 ( ( -LRB- cord-015306-us58wwmp 3212 11 pSFK)-unilateral psfk)-unilateral JJ cord-015306-us58wwmp 3212 12 renal renal JJ cord-015306-us58wwmp 3212 13 agenesis agenesis NN cord-015306-us58wwmp 3212 14 ( ( -LRB- cord-015306-us58wwmp 3212 15 URA URA NNP cord-015306-us58wwmp 3212 16 ) ) -RRB- cord-015306-us58wwmp 3212 17 and and CC cord-015306-us58wwmp 3212 18 secondary secondary JJ cord-015306-us58wwmp 3212 19 SFK SFK NNP cord-015306-us58wwmp 3212 20 ( ( -LRB- cord-015306-us58wwmp 3212 21 sSFK ssfk NN cord-015306-us58wwmp 3212 22 ) ) -RRB- cord-015306-us58wwmp 3212 23 after after IN cord-015306-us58wwmp 3212 24 unilateral unilateral JJ cord-015306-us58wwmp 3212 25 nephrectomy nephrectomy NN cord-015306-us58wwmp 3212 26 . . . cord-015306-us58wwmp 3213 1 The the DT cord-015306-us58wwmp 3213 2 control control NN cord-015306-us58wwmp 3213 3 group group NN cord-015306-us58wwmp 3213 4 ( ( -LRB- cord-015306-us58wwmp 3213 5 C C NNP cord-015306-us58wwmp 3213 6 ) ) -RRB- cord-015306-us58wwmp 3213 7 consisted consist VBD cord-015306-us58wwmp 3213 8 of of IN cord-015306-us58wwmp 3213 9 21 21 CD cord-015306-us58wwmp 3213 10 healthy healthy JJ cord-015306-us58wwmp 3213 11 children child NNS cord-015306-us58wwmp 3213 12 , , . cord-015306-us58wwmp 3214 1 aged aged JJ cord-015306-us58wwmp 3214 2 mean mean JJ cord-015306-us58wwmp 3214 3 9.92 9.92 CD cord-015306-us58wwmp 3214 4 ± ± CD cord-015306-us58wwmp 3214 5 4.85 4.85 CD cord-015306-us58wwmp 3214 6 yrs yr NNS cord-015306-us58wwmp 3214 7 . . . cord-015306-us58wwmp 3215 1 Immunoenzymatic Immunoenzymatic NNP cord-015306-us58wwmp 3215 2 ELISA ELISA NNP cord-015306-us58wwmp 3215 3 commercial commercial JJ cord-015306-us58wwmp 3215 4 kits kit NNS cord-015306-us58wwmp 3215 5 was be VBD cord-015306-us58wwmp 3215 6 used use VBN cord-015306-us58wwmp 3215 7 to to TO cord-015306-us58wwmp 3215 8 measure measure VB cord-015306-us58wwmp 3215 9 pSDMA psdma NN cord-015306-us58wwmp 3215 10 concentration concentration NN cord-015306-us58wwmp 3215 11 . . . cord-015306-us58wwmp 3216 1 Data data NN cord-015306-us58wwmp 3216 2 analysis analysis NN cord-015306-us58wwmp 3216 3 was be VBD cord-015306-us58wwmp 3216 4 performed perform VBN cord-015306-us58wwmp 3216 5 using use VBG cord-015306-us58wwmp 3216 6 computer computer NN cord-015306-us58wwmp 3216 7 program program NN cord-015306-us58wwmp 3216 8 Statistica Statistica NNP cord-015306-us58wwmp 3216 9 9.0 9.0 CD cord-015306-us58wwmp 3216 10 . . . cord-015306-us58wwmp 3217 1 Results result NNS cord-015306-us58wwmp 3217 2 : : : cord-015306-us58wwmp 3218 1 The the DT cord-015306-us58wwmp 3218 2 age age NN cord-015306-us58wwmp 3218 3 and and CC cord-015306-us58wwmp 3218 4 sex sex NN cord-015306-us58wwmp 3218 5 of of IN cord-015306-us58wwmp 3218 6 studied study VBN cord-015306-us58wwmp 3218 7 children child NNS cord-015306-us58wwmp 3218 8 did do VBD cord-015306-us58wwmp 3218 9 not not RB cord-015306-us58wwmp 3218 10 differ differ VB cord-015306-us58wwmp 3218 11 from from IN cord-015306-us58wwmp 3218 12 healthy healthy JJ cord-015306-us58wwmp 3218 13 controls control NNS cord-015306-us58wwmp 3218 14 ( ( -LRB- cord-015306-us58wwmp 3218 15 p p NN cord-015306-us58wwmp 3218 16 > > XX cord-015306-us58wwmp 3218 17 0.05 0.05 CD cord-015306-us58wwmp 3218 18 ) ) -RRB- cord-015306-us58wwmp 3218 19 . . . cord-015306-us58wwmp 3219 1 Plasma plasma NN cord-015306-us58wwmp 3219 2 SDMA SDMA NNP cord-015306-us58wwmp 3219 3 levels level NNS cord-015306-us58wwmp 3219 4 in in IN cord-015306-us58wwmp 3219 5 SFK SFK NNP cord-015306-us58wwmp 3219 6 children child NNS cord-015306-us58wwmp 3219 7 were be VBD cord-015306-us58wwmp 3219 8 higher high JJR cord-015306-us58wwmp 3219 9 than than IN cord-015306-us58wwmp 3219 10 in in IN cord-015306-us58wwmp 3219 11 healthy healthy JJ cord-015306-us58wwmp 3219 12 participants participant NNS cord-015306-us58wwmp 3219 13 ( ( -LRB- cord-015306-us58wwmp 3219 14 p p NN cord-015306-us58wwmp 3219 15 < < XX cord-015306-us58wwmp 3219 16 0.05 0.05 CD cord-015306-us58wwmp 3219 17 ) ) -RRB- cord-015306-us58wwmp 3219 18 . . . cord-015306-us58wwmp 3220 1 There there EX cord-015306-us58wwmp 3220 2 was be VBD cord-015306-us58wwmp 3220 3 no no DT cord-015306-us58wwmp 3220 4 difference difference NN cord-015306-us58wwmp 3220 5 in in IN cord-015306-us58wwmp 3220 6 pSDMA psdma NN cord-015306-us58wwmp 3220 7 concentrations concentration NNS cord-015306-us58wwmp 3220 8 between between IN cord-015306-us58wwmp 3220 9 pSFK psfk NN cord-015306-us58wwmp 3220 10 and and CC cord-015306-us58wwmp 3220 11 sSFK ssfk JJ cord-015306-us58wwmp 3220 12 patients patient NNS cord-015306-us58wwmp 3220 13 ( ( -LRB- cord-015306-us58wwmp 3220 14 p p NN cord-015306-us58wwmp 3220 15 > > XX cord-015306-us58wwmp 3220 16 0.05 0.05 CD cord-015306-us58wwmp 3220 17 ) ) -RRB- cord-015306-us58wwmp 3220 18 . . . cord-015306-us58wwmp 3221 1 SDMA SDMA NNP cord-015306-us58wwmp 3221 2 plasma plasma NN cord-015306-us58wwmp 3221 3 levels level NNS cord-015306-us58wwmp 3221 4 correlated correlate VBD cord-015306-us58wwmp 3221 5 significantly significantly RB cord-015306-us58wwmp 3221 6 with with IN cord-015306-us58wwmp 3221 7 C C NNP cord-015306-us58wwmp 3221 8 cr cr NNP cord-015306-us58wwmp 3221 9 ( ( -LRB- cord-015306-us58wwmp 3221 10 r= r= NNP cord-015306-us58wwmp 3221 11 -0.32 -0.32 CD cord-015306-us58wwmp 3221 12 , , , cord-015306-us58wwmp 3221 13 p p NN cord-015306-us58wwmp 3221 14 < < XX cord-015306-us58wwmp 3221 15 0.01 0.01 CD cord-015306-us58wwmp 3221 16 ) ) -RRB- cord-015306-us58wwmp 3221 17 in in IN cord-015306-us58wwmp 3221 18 all all DT cord-015306-us58wwmp 3221 19 participants participant NNS cord-015306-us58wwmp 3221 20 . . . cord-015306-us58wwmp 3222 1 ROC ROC NNP cord-015306-us58wwmp 3222 2 analyses analysis NNS cord-015306-us58wwmp 3222 3 performed perform VBN cord-015306-us58wwmp 3222 4 in in IN cord-015306-us58wwmp 3222 5 order order NN cord-015306-us58wwmp 3222 6 to to TO cord-015306-us58wwmp 3222 7 define define VB cord-015306-us58wwmp 3222 8 the the DT cord-015306-us58wwmp 3222 9 diagnostic diagnostic JJ cord-015306-us58wwmp 3222 10 efficiency efficiency NN cord-015306-us58wwmp 3222 11 of of IN cord-015306-us58wwmp 3222 12 serum serum NN cord-015306-us58wwmp 3222 13 creatinine creatinine NN cord-015306-us58wwmp 3222 14 and and CC cord-015306-us58wwmp 3222 15 pSDMA psdma NN cord-015306-us58wwmp 3223 1 in in IN cord-015306-us58wwmp 3223 2 identifying identify VBG cord-015306-us58wwmp 3223 3 children child NNS cord-015306-us58wwmp 3223 4 with with IN cord-015306-us58wwmp 3223 5 C C NNP cord-015306-us58wwmp 3223 6 cr cr NN cord-015306-us58wwmp 3223 7 < < XX cord-015306-us58wwmp 3223 8 90ml/ 90ml/ CC cord-015306-us58wwmp 3223 9 min/ min/ CD cord-015306-us58wwmp 3223 10 1.73 1.73 CD cord-015306-us58wwmp 3223 11 m m NN cord-015306-us58wwmp 3223 12 2 2 CD cord-015306-us58wwmp 3223 13 among among IN cord-015306-us58wwmp 3223 14 SFK SFK NNP cord-015306-us58wwmp 3223 15 and and CC cord-015306-us58wwmp 3223 16 healthy healthy JJ cord-015306-us58wwmp 3223 17 participants participant NNS cord-015306-us58wwmp 3223 18 revealed reveal VBD cord-015306-us58wwmp 3223 19 no no DT cord-015306-us58wwmp 3223 20 difference difference NN cord-015306-us58wwmp 3223 21 between between IN cord-015306-us58wwmp 3223 22 all all DT cord-015306-us58wwmp 3223 23 two two CD cord-015306-us58wwmp 3223 24 AUCs auc NNS cord-015306-us58wwmp 3223 25 ( ( -LRB- cord-015306-us58wwmp 3223 26 p p NN cord-015306-us58wwmp 3223 27 > > XX cord-015306-us58wwmp 3223 28 0.05 0.05 CD cord-015306-us58wwmp 3223 29 ) ) -RRB- cord-015306-us58wwmp 3223 30 . . . cord-015306-us58wwmp 3224 1 Conclusion conclusion NN cord-015306-us58wwmp 3224 2 : : : cord-015306-us58wwmp 3225 1 In in IN cord-015306-us58wwmp 3225 2 children child NNS cord-015306-us58wwmp 3225 3 with with IN cord-015306-us58wwmp 3225 4 a a DT cord-015306-us58wwmp 3225 5 solitary solitary JJ cord-015306-us58wwmp 3225 6 functioning function VBG cord-015306-us58wwmp 3225 7 kidney kidney NN cord-015306-us58wwmp 3225 8 increased increase VBD cord-015306-us58wwmp 3225 9 pSDMA psdma NN cord-015306-us58wwmp 3225 10 levels level NNS cord-015306-us58wwmp 3225 11 were be VBD cord-015306-us58wwmp 3225 12 observed observe VBN cord-015306-us58wwmp 3225 13 , , , cord-015306-us58wwmp 3225 14 however however RB cord-015306-us58wwmp 3225 15 the the DT cord-015306-us58wwmp 3225 16 sensitivity sensitivity NN cord-015306-us58wwmp 3225 17 and and CC cord-015306-us58wwmp 3225 18 specificity specificity NN cord-015306-us58wwmp 3225 19 of of IN cord-015306-us58wwmp 3225 20 this this DT cord-015306-us58wwmp 3225 21 marker marker NN cord-015306-us58wwmp 3225 22 in in IN cord-015306-us58wwmp 3225 23 detecting detect VBG cord-015306-us58wwmp 3225 24 the the DT cord-015306-us58wwmp 3225 25 decrease decrease NN cord-015306-us58wwmp 3225 26 in in IN cord-015306-us58wwmp 3225 27 C C NNP cord-015306-us58wwmp 3225 28 cr cr NNP cord-015306-us58wwmp 3225 29 was be VBD cord-015306-us58wwmp 3225 30 not not RB cord-015306-us58wwmp 3225 31 better well JJR cord-015306-us58wwmp 3225 32 than than IN cord-015306-us58wwmp 3225 33 creatinine creatinine NN cord-015306-us58wwmp 3225 34 . . . cord-015306-us58wwmp 3226 1 Objective objective JJ cord-015306-us58wwmp 3226 2 : : : cord-015306-us58wwmp 3226 3 Renal renal JJ cord-015306-us58wwmp 3226 4 osteodystrophy osteodystrophy NN cord-015306-us58wwmp 3226 5 encompasses encompass VBZ cord-015306-us58wwmp 3226 6 a a DT cord-015306-us58wwmp 3226 7 variety variety NN cord-015306-us58wwmp 3226 8 of of IN cord-015306-us58wwmp 3226 9 skeletal skeletal JJ cord-015306-us58wwmp 3226 10 disorder disorder NN cord-015306-us58wwmp 3226 11 ranging range VBG cord-015306-us58wwmp 3226 12 from from IN cord-015306-us58wwmp 3226 13 high high JJ cord-015306-us58wwmp 3226 14 turnover turnover NN cord-015306-us58wwmp 3226 15 lesions lesion NNS cord-015306-us58wwmp 3226 16 of of IN cord-015306-us58wwmp 3226 17 secondary secondary JJ cord-015306-us58wwmp 3226 18 hyperparathyroidism hyperparathyroidism NN cord-015306-us58wwmp 3226 19 ( ( -LRB- cord-015306-us58wwmp 3226 20 SHPT SHPT NNP cord-015306-us58wwmp 3226 21 ) ) -RRB- cord-015306-us58wwmp 3226 22 , , , cord-015306-us58wwmp 3226 23 to to IN cord-015306-us58wwmp 3226 24 low low JJ cord-015306-us58wwmp 3226 25 turnover turnover NN cord-015306-us58wwmp 3226 26 lesionsof lesionsof FW cord-015306-us58wwmp 3226 27 diverse diverse JJ cord-015306-us58wwmp 3226 28 etiology etiology NN cord-015306-us58wwmp 3226 29 that that WDT cord-015306-us58wwmp 3226 30 are be VBP cord-015306-us58wwmp 3226 31 usually usually RB cord-015306-us58wwmp 3226 32 associated associate VBN cord-015306-us58wwmp 3226 33 with with IN cord-015306-us58wwmp 3226 34 normal normal JJ cord-015306-us58wwmp 3226 35 or or CC cord-015306-us58wwmp 3226 36 reduced reduce VBN cord-015306-us58wwmp 3226 37 PTH PTH NNP cord-015306-us58wwmp 3226 38 levels level NNS cord-015306-us58wwmp 3226 39 . . . cord-015306-us58wwmp 3227 1 So so RB cord-015306-us58wwmp 3227 2 our -PRON- PRP$ cord-015306-us58wwmp 3227 3 aim aim NN cord-015306-us58wwmp 3227 4 was be VBD cord-015306-us58wwmp 3227 5 to to TO cord-015306-us58wwmp 3227 6 assess assess VB cord-015306-us58wwmp 3227 7 by by IN cord-015306-us58wwmp 3227 8 DEXA DEXA NNP cord-015306-us58wwmp 3227 9 which which WDT cord-015306-us58wwmp 3227 10 is be VBZ cord-015306-us58wwmp 3227 11 a a DT cord-015306-us58wwmp 3227 12 precise precise JJ cord-015306-us58wwmp 3227 13 , , , cord-015306-us58wwmp 3227 14 rapid rapid JJ cord-015306-us58wwmp 3227 15 and and CC cord-015306-us58wwmp 3227 16 noninvasive noninvasive JJ cord-015306-us58wwmp 3227 17 procedure procedure NN cord-015306-us58wwmp 3228 1 the the DT cord-015306-us58wwmp 3228 2 degree degree NN cord-015306-us58wwmp 3228 3 of of IN cord-015306-us58wwmp 3228 4 osteopenia osteopenia NN cord-015306-us58wwmp 3228 5 in in IN cord-015306-us58wwmp 3228 6 patients patient NNS cord-015306-us58wwmp 3228 7 with with IN cord-015306-us58wwmp 3228 8 CRF CRF NNP cord-015306-us58wwmp 3228 9 . . . cord-015306-us58wwmp 3229 1 Methods method NNS cord-015306-us58wwmp 3229 2 : : : cord-015306-us58wwmp 3229 3 53 53 CD cord-015306-us58wwmp 3229 4 children child NNS cord-015306-us58wwmp 3229 5 aged age VBN cord-015306-us58wwmp 3229 6 ( ( -LRB- cord-015306-us58wwmp 3229 7 11 11 CD cord-015306-us58wwmp 3229 8 - - SYM cord-015306-us58wwmp 3229 9 3.84 3.84 CD cord-015306-us58wwmp 3229 10 ) ) -RRB- cord-015306-us58wwmp 3229 11 years year NNS cord-015306-us58wwmp 3229 12 , , , cord-015306-us58wwmp 3229 13 17 17 CD cord-015306-us58wwmp 3229 14 on on IN cord-015306-us58wwmp 3229 15 conservative conservative JJ cord-015306-us58wwmp 3229 16 treatment treatment NN cord-015306-us58wwmp 3229 17 and and CC cord-015306-us58wwmp 3229 18 36 36 CD cord-015306-us58wwmp 3229 19 on on IN cord-015306-us58wwmp 3229 20 hemodialysis hemodialysis NN cord-015306-us58wwmp 3229 21 were be VBD cord-015306-us58wwmp 3229 22 included include VBN cord-015306-us58wwmp 3229 23 in in IN cord-015306-us58wwmp 3229 24 the the DT cord-015306-us58wwmp 3229 25 study study NN cord-015306-us58wwmp 3229 26 BMD bmd NN cord-015306-us58wwmp 3229 27 of of IN cord-015306-us58wwmp 3229 28 lumbar lumbar JJ cord-015306-us58wwmp 3229 29 spine spine NN cord-015306-us58wwmp 3229 30 and and CC cord-015306-us58wwmp 3229 31 wrist wrist NN cord-015306-us58wwmp 3229 32 were be VBD cord-015306-us58wwmp 3229 33 measured measure VBN cord-015306-us58wwmp 3229 34 by by IN cord-015306-us58wwmp 3229 35 ( ( -LRB- cord-015306-us58wwmp 3229 36 DEXA DEXA NNP cord-015306-us58wwmp 3229 37 ) ) -RRB- cord-015306-us58wwmp 3229 38 and and CC cord-015306-us58wwmp 3229 39 compared compare VBN cord-015306-us58wwmp 3229 40 with with IN cord-015306-us58wwmp 3229 41 age age NN cord-015306-us58wwmp 3229 42 and and CC cord-015306-us58wwmp 3229 43 sex sex NN cord-015306-us58wwmp 3229 44 matched match VBN cord-015306-us58wwmp 3229 45 controls control NNS cord-015306-us58wwmp 3229 46 . . . cord-015306-us58wwmp 3230 1 Results result NNS cord-015306-us58wwmp 3230 2 : : : cord-015306-us58wwmp 3230 3 shows show VBZ cord-015306-us58wwmp 3230 4 that that IN cord-015306-us58wwmp 3230 5 out out IN cord-015306-us58wwmp 3230 6 of of IN cord-015306-us58wwmp 3230 7 53 53 CD cord-015306-us58wwmp 3230 8 patients patient NNS cord-015306-us58wwmp 3230 9 , , , cord-015306-us58wwmp 3230 10 25 25 CD cord-015306-us58wwmp 3230 11 ( ( -LRB- cord-015306-us58wwmp 3230 12 47 47 CD cord-015306-us58wwmp 3230 13 % % NN cord-015306-us58wwmp 3230 14 ) ) -RRB- cord-015306-us58wwmp 3230 15 are be VBP cord-015306-us58wwmp 3230 16 osteopenic osteopenic NNP cord-015306-us58wwmp 3230 17 22 22 CD cord-015306-us58wwmp 3230 18 ( ( -LRB- cord-015306-us58wwmp 3230 19 88 88 CD cord-015306-us58wwmp 3230 20 % % NN cord-015306-us58wwmp 3230 21 ) ) -RRB- cord-015306-us58wwmp 3230 22 on on IN cord-015306-us58wwmp 3230 23 hemodialysis hemodialysis NN cord-015306-us58wwmp 3230 24 and and CC cord-015306-us58wwmp 3230 25 3 3 CD cord-015306-us58wwmp 3230 26 ( ( -LRB- cord-015306-us58wwmp 3230 27 12 12 CD cord-015306-us58wwmp 3230 28 % % NN cord-015306-us58wwmp 3230 29 ) ) -RRB- cord-015306-us58wwmp 3230 30 on on IN cord-015306-us58wwmp 3230 31 conservative conservative JJ cord-015306-us58wwmp 3230 32 treatment treatment NN cord-015306-us58wwmp 3230 33 , , , cord-015306-us58wwmp 3230 34 of of IN cord-015306-us58wwmp 3230 35 these these DT cord-015306-us58wwmp 3230 36 13 13 CD cord-015306-us58wwmp 3230 37 ( ( -LRB- cord-015306-us58wwmp 3230 38 24.4 24.4 CD cord-015306-us58wwmp 3230 39 % % NN cord-015306-us58wwmp 3230 40 ) ) -RRB- cord-015306-us58wwmp 3230 41 had have VBD cord-015306-us58wwmp 3230 42 severe severe JJ cord-015306-us58wwmp 3230 43 osteopenia osteopenia NN cord-015306-us58wwmp 3230 44 as as IN cord-015306-us58wwmp 3230 45 regard regard NN cord-015306-us58wwmp 3230 46 BMD bmd NN cord-015306-us58wwmp 3230 47 of of IN cord-015306-us58wwmp 3230 48 the the DT cord-015306-us58wwmp 3230 49 spine spine NN cord-015306-us58wwmp 3230 50 , , , cord-015306-us58wwmp 3230 51 while while IN cord-015306-us58wwmp 3230 52 DEXAwrist dexawrist NN cord-015306-us58wwmp 3230 53 shows show VBZ cord-015306-us58wwmp 3230 54 11 11 CD cord-015306-us58wwmp 3230 55 ( ( -LRB- cord-015306-us58wwmp 3230 56 21 21 CD cord-015306-us58wwmp 3230 57 % % NN cord-015306-us58wwmp 3230 58 ) ) -RRB- cord-015306-us58wwmp 3230 59 are be VBP cord-015306-us58wwmp 3230 60 osteopenic osteopenic JJ cord-015306-us58wwmp 3230 61 , , , cord-015306-us58wwmp 3230 62 7 7 CD cord-015306-us58wwmp 3230 63 ( ( -LRB- cord-015306-us58wwmp 3230 64 64 64 CD cord-015306-us58wwmp 3230 65 % % NN cord-015306-us58wwmp 3230 66 ) ) -RRB- cord-015306-us58wwmp 3230 67 on on IN cord-015306-us58wwmp 3230 68 regular regular JJ cord-015306-us58wwmp 3230 69 hemodialysis hemodialysis NN cord-015306-us58wwmp 3230 70 and and CC cord-015306-us58wwmp 3230 71 4 4 CD cord-015306-us58wwmp 3230 72 ( ( -LRB- cord-015306-us58wwmp 3230 73 36 36 CD cord-015306-us58wwmp 3230 74 % % NN cord-015306-us58wwmp 3230 75 ) ) -RRB- cord-015306-us58wwmp 3230 76 on on IN cord-015306-us58wwmp 3230 77 conservative conservative JJ cord-015306-us58wwmp 3230 78 III III NNP cord-015306-us58wwmp 3230 79 , , , cord-015306-us58wwmp 3230 80 of of IN cord-015306-us58wwmp 3230 81 these these DT cord-015306-us58wwmp 3230 82 3 3 CD cord-015306-us58wwmp 3230 83 ( ( -LRB- cord-015306-us58wwmp 3230 84 5.66 5.66 CD cord-015306-us58wwmp 3230 85 % % NN cord-015306-us58wwmp 3230 86 ) ) -RRB- cord-015306-us58wwmp 3230 87 had have VBD cord-015306-us58wwmp 3230 88 severe severe JJ cord-015306-us58wwmp 3230 89 osteopenia osteopenia NN cord-015306-us58wwmp 3230 90 , , , cord-015306-us58wwmp 3230 91 correlation correlation NN cord-015306-us58wwmp 3230 92 between between IN cord-015306-us58wwmp 3230 93 Z z NN cord-015306-us58wwmp 3230 94 - - HYPH cord-015306-us58wwmp 3230 95 score score NN cord-015306-us58wwmp 3230 96 spine spine NN cord-015306-us58wwmp 3230 97 in in IN cord-015306-us58wwmp 3230 98 the the DT cord-015306-us58wwmp 3230 99 osteopenic osteopenic NNP cord-015306-us58wwmp 3230 100 group group NN cord-015306-us58wwmp 3230 101 and and CC cord-015306-us58wwmp 3230 102 different different JJ cord-015306-us58wwmp 3230 103 biochemical biochemical JJ cord-015306-us58wwmp 3230 104 parameters parameter NNS cord-015306-us58wwmp 3230 105 shows show VBZ cord-015306-us58wwmp 3230 106 non non JJ cord-015306-us58wwmp 3230 107 - - JJ cord-015306-us58wwmp 3230 108 significant significant JJ cord-015306-us58wwmp 3230 109 correlation correlation NN cord-015306-us58wwmp 3230 110 except except IN cord-015306-us58wwmp 3230 111 -ve -ve . cord-015306-us58wwmp 3231 1 correlation correlation NN cord-015306-us58wwmp 3231 2 with with IN cord-015306-us58wwmp 3231 3 duration duration NN cord-015306-us58wwmp 3231 4 and and CC cord-015306-us58wwmp 3231 5 age age NN cord-015306-us58wwmp 3231 6 of of IN cord-015306-us58wwmp 3231 7 the the DT cord-015306-us58wwmp 3231 8 patients patient NNS cord-015306-us58wwmp 3231 9 , , , cord-015306-us58wwmp 3231 10 while while IN cord-015306-us58wwmp 3231 11 Z z NN cord-015306-us58wwmp 3231 12 - - HYPH cord-015306-us58wwmp 3231 13 score score NN cord-015306-us58wwmp 3231 14 wrist wrist NN cord-015306-us58wwmp 3231 15 of of IN cord-015306-us58wwmp 3231 16 the the DT cord-015306-us58wwmp 3231 17 same same JJ cord-015306-us58wwmp 3231 18 group group NN cord-015306-us58wwmp 3231 19 shows show VBZ cord-015306-us58wwmp 3231 20 + + CC cord-015306-us58wwmp 3231 21 ve ve VBD cord-015306-us58wwmp 3231 22 correlation correlation NN cord-015306-us58wwmp 3231 23 with with IN cord-015306-us58wwmp 3231 24 bicarbonate bicarbonate NN cord-015306-us58wwmp 3231 25 . . . cord-015306-us58wwmp 3232 1 our -PRON- PRP$ cord-015306-us58wwmp 3232 2 result result NN cord-015306-us58wwmp 3232 3 shows show VBZ cord-015306-us58wwmp 3232 4 that that DT cord-015306-us58wwmp 3232 5 group group NN cord-015306-us58wwmp 3232 6 with with IN cord-015306-us58wwmp 3232 7 IPTH IPTH NNP cord-015306-us58wwmp 3233 1 > > XX cord-015306-us58wwmp 3234 1 = = SYM cord-015306-us58wwmp 3234 2 200 200 CD cord-015306-us58wwmp 3234 3 pg pg NN cord-015306-us58wwmp 3234 4 / / SYM cord-015306-us58wwmp 3234 5 ml ml NNS cord-015306-us58wwmp 3234 6 are be VBP cord-015306-us58wwmp 3234 7 more more RBR cord-015306-us58wwmp 3234 8 osteopenic osteopenic JJ cord-015306-us58wwmp 3234 9 than than IN cord-015306-us58wwmp 3234 10 those those DT cord-015306-us58wwmp 3234 11 with with IN cord-015306-us58wwmp 3234 12 lower low JJR cord-015306-us58wwmp 3234 13 IPHT IPHT NNP cord-015306-us58wwmp 3234 14 levels level NNS cord-015306-us58wwmp 3234 15 , , , cord-015306-us58wwmp 3234 16 although although IN cord-015306-us58wwmp 3234 17 difference difference NN cord-015306-us58wwmp 3234 18 did do VBD cord-015306-us58wwmp 3234 19 not not RB cord-015306-us58wwmp 3234 20 reach reach VB cord-015306-us58wwmp 3234 21 level level NN cord-015306-us58wwmp 3234 22 of of IN cord-015306-us58wwmp 3234 23 statistical statistical JJ cord-015306-us58wwmp 3234 24 significance significance NN cord-015306-us58wwmp 3234 25 P p NN cord-015306-us58wwmp 3234 26 > > XX cord-015306-us58wwmp 3234 27 0.05 0.05 CD cord-015306-us58wwmp 3234 28 . . . cord-015306-us58wwmp 3235 1 Conclusion conclusion NN cord-015306-us58wwmp 3235 2 : : : cord-015306-us58wwmp 3235 3 We -PRON- PRP cord-015306-us58wwmp 3235 4 can can MD cord-015306-us58wwmp 3235 5 conclude conclude VB cord-015306-us58wwmp 3235 6 that that IN cord-015306-us58wwmp 3235 7 osteopenia osteopenia NN cord-015306-us58wwmp 3235 8 is be VBZ cord-015306-us58wwmp 3235 9 frequent frequent JJ cord-015306-us58wwmp 3235 10 in in IN cord-015306-us58wwmp 3235 11 patients patient NNS cord-015306-us58wwmp 3235 12 with with IN cord-015306-us58wwmp 3235 13 CRF CRF NNP cord-015306-us58wwmp 3235 14 more more JJR cord-015306-us58wwmp 3235 15 in in IN cord-015306-us58wwmp 3235 16 the the DT cord-015306-us58wwmp 3235 17 dialyzed dialyzed JJ cord-015306-us58wwmp 3235 18 group group NN cord-015306-us58wwmp 3235 19 , , , cord-015306-us58wwmp 3235 20 with with IN cord-015306-us58wwmp 3235 21 longer long JJR cord-015306-us58wwmp 3235 22 duration duration NN cord-015306-us58wwmp 3235 23 of of IN cord-015306-us58wwmp 3235 24 the the DT cord-015306-us58wwmp 3235 25 disease disease NN cord-015306-us58wwmp 3235 26 , , , cord-015306-us58wwmp 3235 27 older old JJR cord-015306-us58wwmp 3235 28 age age NN cord-015306-us58wwmp 3235 29 and and CC cord-015306-us58wwmp 3235 30 severe severe JJ cord-015306-us58wwmp 3235 31 acidosis acidosis NN cord-015306-us58wwmp 3235 32 , , , cord-015306-us58wwmp 3235 33 irrespective irrespective RB cord-015306-us58wwmp 3235 34 of of IN cord-015306-us58wwmp 3235 35 the the DT cord-015306-us58wwmp 3235 36 severity severity NN cord-015306-us58wwmp 3235 37 of of IN cord-015306-us58wwmp 3235 38 the the DT cord-015306-us58wwmp 3235 39 disease disease NN cord-015306-us58wwmp 3235 40 . . . cord-015306-us58wwmp 3236 1 Although although IN cord-015306-us58wwmp 3236 2 , , , cord-015306-us58wwmp 3236 3 degree degree NN cord-015306-us58wwmp 3236 4 of of IN cord-015306-us58wwmp 3236 5 osteopenia osteopenia NN cord-015306-us58wwmp 3236 6 is be VBZ cord-015306-us58wwmp 3236 7 not not RB cord-015306-us58wwmp 3236 8 correlated correlate VBN cord-015306-us58wwmp 3236 9 with with IN cord-015306-us58wwmp 3236 10 biochemical biochemical JJ cord-015306-us58wwmp 3236 11 findings finding NNS cord-015306-us58wwmp 3236 12 of of IN cord-015306-us58wwmp 3236 13 ( ( -LRB- cord-015306-us58wwmp 3236 14 SHPT SHPT NNP cord-015306-us58wwmp 3236 15 ) ) -RRB- cord-015306-us58wwmp 3236 16 but but CC cord-015306-us58wwmp 3236 17 still still RB cord-015306-us58wwmp 3236 18 patients patient NNS cord-015306-us58wwmp 3236 19 with with IN cord-015306-us58wwmp 3236 20 ( ( -LRB- cord-015306-us58wwmp 3236 21 SHPT SHPT NNP cord-015306-us58wwmp 3236 22 ) ) -RRB- cord-015306-us58wwmp 3236 23 are be VBP cord-015306-us58wwmp 3236 24 more more RBR cord-015306-us58wwmp 3236 25 osteopenic osteopenic JJ cord-015306-us58wwmp 3236 26 and and CC cord-015306-us58wwmp 3236 27 have have VBP cord-015306-us58wwmp 3236 28 lower low JJR cord-015306-us58wwmp 3236 29 cortical cortical JJ cord-015306-us58wwmp 3236 30 bone bone NN cord-015306-us58wwmp 3236 31 density density NN cord-015306-us58wwmp 3236 32 . . . cord-015306-us58wwmp 3237 1 Mineral mineral NN cord-015306-us58wwmp 3237 2 and and CC cord-015306-us58wwmp 3237 3 bone bone NN cord-015306-us58wwmp 3237 4 disorders disorder NNS cord-015306-us58wwmp 3237 5 were be VBD cord-015306-us58wwmp 3237 6 defined define VBN cord-015306-us58wwmp 3237 7 according accord VBG cord-015306-us58wwmp 3237 8 to to IN cord-015306-us58wwmp 3237 9 K K NNP cord-015306-us58wwmp 3237 10 / / SYM cord-015306-us58wwmp 3237 11 DOQI DOQI NNP cord-015306-us58wwmp 3237 12 guidelines guideline NNS cord-015306-us58wwmp 3237 13 . . . cord-015306-us58wwmp 3238 1 Results result NNS cord-015306-us58wwmp 3238 2 : : : cord-015306-us58wwmp 3239 1 During during IN cord-015306-us58wwmp 3239 2 the the DT cord-015306-us58wwmp 3239 3 study study NN cord-015306-us58wwmp 3239 4 period period NN cord-015306-us58wwmp 3239 5 95 95 CD cord-015306-us58wwmp 3239 6 % % NN cord-015306-us58wwmp 3239 7 of of IN cord-015306-us58wwmp 3239 8 stage stage NN cord-015306-us58wwmp 3239 9 I I NNP cord-015306-us58wwmp 3239 10 - - HYPH cord-015306-us58wwmp 3239 11 IV IV NNP cord-015306-us58wwmp 3239 12 CKD CKD NNP cord-015306-us58wwmp 3239 13 patients patient NNS cord-015306-us58wwmp 3239 14 and and CC cord-015306-us58wwmp 3239 15 all all DT cord-015306-us58wwmp 3239 16 ESRD ESRD NNP cord-015306-us58wwmp 3239 17 patients patient NNS cord-015306-us58wwmp 3239 18 and and CC cord-015306-us58wwmp 3239 19 renal renal JJ cord-015306-us58wwmp 3239 20 allograft allograft NN cord-015306-us58wwmp 3239 21 recipients recipient NNS cord-015306-us58wwmp 3239 22 had have VBD cord-015306-us58wwmp 3239 23 at at RB cord-015306-us58wwmp 3239 24 least least RBS cord-015306-us58wwmp 3239 25 one one CD cord-015306-us58wwmp 3239 26 type type NN cord-015306-us58wwmp 3239 27 of of IN cord-015306-us58wwmp 3239 28 MBD MBD NNP cord-015306-us58wwmp 3239 29 . . . cord-015306-us58wwmp 3240 1 High high JJ cord-015306-us58wwmp 3240 2 turnover turnover NN cord-015306-us58wwmp 3240 3 bone bone NN cord-015306-us58wwmp 3240 4 disease disease NN cord-015306-us58wwmp 3240 5 with with IN cord-015306-us58wwmp 3240 6 hyperphosphatemia hyperphosphatemia NN cord-015306-us58wwmp 3240 7 , , , cord-015306-us58wwmp 3240 8 hyperparathyroidism hyperparathyroidism NN cord-015306-us58wwmp 3240 9 and and CC cord-015306-us58wwmp 3240 10 hypocalcemia hypocalcemia NN cord-015306-us58wwmp 3240 11 was be VBD cord-015306-us58wwmp 3240 12 the the DT cord-015306-us58wwmp 3240 13 most most RBS cord-015306-us58wwmp 3240 14 frequent frequent JJ cord-015306-us58wwmp 3240 15 type type NN cord-015306-us58wwmp 3240 16 of of IN cord-015306-us58wwmp 3240 17 MBD MBD NNP cord-015306-us58wwmp 3240 18 in in IN cord-015306-us58wwmp 3240 19 stage stage NN cord-015306-us58wwmp 3240 20 I I NNP cord-015306-us58wwmp 3240 21 - - HYPH cord-015306-us58wwmp 3240 22 IV IV NNP cord-015306-us58wwmp 3240 23 CKD CKD NNP cord-015306-us58wwmp 3240 24 and and CC cord-015306-us58wwmp 3240 25 ESRD ESRD NNP cord-015306-us58wwmp 3240 26 patient patient NN cord-015306-us58wwmp 3240 27 . . . cord-015306-us58wwmp 3241 1 Adynamic adynamic JJ cord-015306-us58wwmp 3241 2 bone bone NN cord-015306-us58wwmp 3241 3 disease disease NN cord-015306-us58wwmp 3241 4 was be VBD cord-015306-us58wwmp 3241 5 seen see VBN cord-015306-us58wwmp 3241 6 in in IN cord-015306-us58wwmp 3241 7 only only RB cord-015306-us58wwmp 3241 8 one one CD cord-015306-us58wwmp 3241 9 ESRD ESRD NNP cord-015306-us58wwmp 3241 10 patient patient NN cord-015306-us58wwmp 3241 11 . . . cord-015306-us58wwmp 3242 1 Hypophasphatemia Hypophasphatemia NNP cord-015306-us58wwmp 3242 2 was be VBD cord-015306-us58wwmp 3242 3 the the DT cord-015306-us58wwmp 3242 4 most most RBS cord-015306-us58wwmp 3242 5 common common JJ cord-015306-us58wwmp 3242 6 disorder disorder NN cord-015306-us58wwmp 3242 7 in in IN cord-015306-us58wwmp 3242 8 renal renal JJ cord-015306-us58wwmp 3242 9 allograft allograft NN cord-015306-us58wwmp 3242 10 recipients recipient NNS cord-015306-us58wwmp 3242 11 . . . cord-015306-us58wwmp 3243 1 Vitamin vitamin NN cord-015306-us58wwmp 3243 2 D d NN cord-015306-us58wwmp 3243 3 deficiency deficiency NN cord-015306-us58wwmp 3243 4 / / SYM cord-015306-us58wwmp 3243 5 insufficiency insufficiency NN cord-015306-us58wwmp 3243 6 was be VBD cord-015306-us58wwmp 3243 7 seen see VBN cord-015306-us58wwmp 3243 8 in in IN cord-015306-us58wwmp 3243 9 55 55 CD cord-015306-us58wwmp 3243 10 % % NN cord-015306-us58wwmp 3243 11 of of IN cord-015306-us58wwmp 3243 12 stage stage NN cord-015306-us58wwmp 3243 13 I I NNP cord-015306-us58wwmp 3243 14 - - HYPH cord-015306-us58wwmp 3243 15 IV IV NNP cord-015306-us58wwmp 3243 16 CKD CKD NNP cord-015306-us58wwmp 3243 17 , , , cord-015306-us58wwmp 3243 18 65 65 CD cord-015306-us58wwmp 3243 19 % % NN cord-015306-us58wwmp 3243 20 of of IN cord-015306-us58wwmp 3243 21 ESRD ESRD NNP cord-015306-us58wwmp 3243 22 patients patient NNS cord-015306-us58wwmp 3243 23 and and CC cord-015306-us58wwmp 3243 24 all all DT cord-015306-us58wwmp 3243 25 renal renal JJ cord-015306-us58wwmp 3243 26 allograft allograft NN cord-015306-us58wwmp 3243 27 recipients recipient NNS cord-015306-us58wwmp 3243 28 . . . cord-015306-us58wwmp 3244 1 All all DT cord-015306-us58wwmp 3244 2 patients patient NNS cord-015306-us58wwmp 3244 3 with with IN cord-015306-us58wwmp 3244 4 stage stage NN cord-015306-us58wwmp 3244 5 I I NNP cord-015306-us58wwmp 3244 6 - - HYPH cord-015306-us58wwmp 3244 7 IV IV NNP cord-015306-us58wwmp 3244 8 CKD CKD NNP cord-015306-us58wwmp 3244 9 and and CC cord-015306-us58wwmp 3244 10 ESRD ESRD NNP cord-015306-us58wwmp 3244 11 were be VBD cord-015306-us58wwmp 3244 12 treated treat VBN cord-015306-us58wwmp 3244 13 with with IN cord-015306-us58wwmp 3244 14 calsitriol calsitriol NNP cord-015306-us58wwmp 3244 15 and and CC cord-015306-us58wwmp 3244 16 renal renal JJ cord-015306-us58wwmp 3244 17 allograft allograft NN cord-015306-us58wwmp 3244 18 recipients recipient NNS cord-015306-us58wwmp 3244 19 were be VBD cord-015306-us58wwmp 3244 20 treated treat VBN cord-015306-us58wwmp 3244 21 with with IN cord-015306-us58wwmp 3244 22 vitamin vitamin NN cord-015306-us58wwmp 3244 23 D3 D3 NNP cord-015306-us58wwmp 3244 24 supplementation supplementation NN cord-015306-us58wwmp 3244 25 . . . cord-015306-us58wwmp 3245 1 Conclusion conclusion NN cord-015306-us58wwmp 3245 2 : : : cord-015306-us58wwmp 3245 3 Mineral mineral NN cord-015306-us58wwmp 3245 4 and and CC cord-015306-us58wwmp 3245 5 bone bone NN cord-015306-us58wwmp 3245 6 disorders disorder NNS cord-015306-us58wwmp 3245 7 especially especially RB cord-015306-us58wwmp 3245 8 high high JJ cord-015306-us58wwmp 3245 9 turnerover turnerover NN cord-015306-us58wwmp 3245 10 type type NN cord-015306-us58wwmp 3245 11 is be VBZ cord-015306-us58wwmp 3245 12 common common JJ cord-015306-us58wwmp 3245 13 in in IN cord-015306-us58wwmp 3245 14 children child NNS cord-015306-us58wwmp 3245 15 with with IN cord-015306-us58wwmp 3245 16 CKD CKD NNP cord-015306-us58wwmp 3245 17 and and CC cord-015306-us58wwmp 3245 18 ESRD ESRD NNP cord-015306-us58wwmp 3245 19 . . . cord-015306-us58wwmp 3246 1 Although although IN cord-015306-us58wwmp 3246 2 successful successful JJ cord-015306-us58wwmp 3246 3 kidney kidney NN cord-015306-us58wwmp 3246 4 transplantation transplantation NN cord-015306-us58wwmp 3246 5 corrects correct VBZ cord-015306-us58wwmp 3246 6 many many JJ cord-015306-us58wwmp 3246 7 of of IN cord-015306-us58wwmp 3246 8 the the DT cord-015306-us58wwmp 3246 9 metabolic metabolic JJ cord-015306-us58wwmp 3246 10 abnormalities abnormality NNS cord-015306-us58wwmp 3246 11 associated associate VBN cord-015306-us58wwmp 3246 12 with with IN cord-015306-us58wwmp 3246 13 the the DT cord-015306-us58wwmp 3246 14 development development NN cord-015306-us58wwmp 3246 15 of of IN cord-015306-us58wwmp 3246 16 MBDs MBDs NNP cord-015306-us58wwmp 3246 17 , , , cord-015306-us58wwmp 3246 18 renal renal JJ cord-015306-us58wwmp 3246 19 allograft allograft NN cord-015306-us58wwmp 3246 20 recipients recipient NNS cord-015306-us58wwmp 3246 21 had have VBD cord-015306-us58wwmp 3246 22 increased increase VBN cord-015306-us58wwmp 3246 23 risk risk NN cord-015306-us58wwmp 3246 24 of of IN cord-015306-us58wwmp 3246 25 vitamin vitamin NN cord-015306-us58wwmp 3246 26 D D NNP cord-015306-us58wwmp 3246 27 deficiency deficiency NN cord-015306-us58wwmp 3246 28 / / SYM cord-015306-us58wwmp 3246 29 insufficiency insufficiency NN cord-015306-us58wwmp 3246 30 . . . cord-015306-us58wwmp 3247 1 Objective objective JJ cord-015306-us58wwmp 3247 2 : : : cord-015306-us58wwmp 3247 3 Calciphylaxis Calciphylaxis NNP cord-015306-us58wwmp 3247 4 is be VBZ cord-015306-us58wwmp 3247 5 a a DT cord-015306-us58wwmp 3247 6 complication complication NN cord-015306-us58wwmp 3247 7 of of IN cord-015306-us58wwmp 3247 8 chronic chronic JJ cord-015306-us58wwmp 3247 9 kidney kidney NN cord-015306-us58wwmp 3247 10 disease disease NN cord-015306-us58wwmp 3247 11 that that WDT cord-015306-us58wwmp 3247 12 characterized characterize VBN cord-015306-us58wwmp 3247 13 by by IN cord-015306-us58wwmp 3247 14 necrotic necrotic JJ cord-015306-us58wwmp 3247 15 lesion lesion NN cord-015306-us58wwmp 3247 16 in in IN cord-015306-us58wwmp 3247 17 the the DT cord-015306-us58wwmp 3247 18 skin skin NN cord-015306-us58wwmp 3247 19 and and CC cord-015306-us58wwmp 3247 20 in in IN cord-015306-us58wwmp 3247 21 histological histological JJ cord-015306-us58wwmp 3247 22 examination examination NN cord-015306-us58wwmp 3247 23 reveals reveal VBZ cord-015306-us58wwmp 3247 24 microcalcification microcalcification NN cord-015306-us58wwmp 3247 25 of of IN cord-015306-us58wwmp 3247 26 medium medium JJ cord-015306-us58wwmp 3247 27 sized sized JJ cord-015306-us58wwmp 3247 28 blood blood NN cord-015306-us58wwmp 3247 29 vessels vessel NNS cord-015306-us58wwmp 3247 30 . . . cord-015306-us58wwmp 3248 1 Materials material NNS cord-015306-us58wwmp 3248 2 and and CC cord-015306-us58wwmp 3248 3 Methods method NNS cord-015306-us58wwmp 3248 4 : : : cord-015306-us58wwmp 3248 5 We -PRON- PRP cord-015306-us58wwmp 3248 6 report report VBP cord-015306-us58wwmp 3248 7 on on IN cord-015306-us58wwmp 3248 8 a a DT cord-015306-us58wwmp 3248 9 21-month 21-month JJ cord-015306-us58wwmp 3248 10 old old JJ cord-015306-us58wwmp 3248 11 girl girl NN cord-015306-us58wwmp 3248 12 with with IN cord-015306-us58wwmp 3248 13 end end NN cord-015306-us58wwmp 3248 14 stage stage NN cord-015306-us58wwmp 3248 15 renal renal JJ cord-015306-us58wwmp 3248 16 disease disease NN cord-015306-us58wwmp 3248 17 due due JJ cord-015306-us58wwmp 3248 18 to to TO cord-015306-us58wwmp 3248 19 diffuse diffuse VB cord-015306-us58wwmp 3248 20 mesangial mesangial JJ cord-015306-us58wwmp 3248 21 sclerosis sclerosis NN cord-015306-us58wwmp 3248 22 referred refer VBN cord-015306-us58wwmp 3248 23 for for IN cord-015306-us58wwmp 3248 24 Tenckhoff Tenckhoff NNP cord-015306-us58wwmp 3248 25 catheter catheter NN cord-015306-us58wwmp 3248 26 implantation implantation NN cord-015306-us58wwmp 3248 27 . . . cord-015306-us58wwmp 3249 1 Laboratory laboratory NN cord-015306-us58wwmp 3249 2 tests test NNS cord-015306-us58wwmp 3249 3 on on IN cord-015306-us58wwmp 3249 4 admission admission NN cord-015306-us58wwmp 3249 5 were be VBD cord-015306-us58wwmp 3249 6 : : : cord-015306-us58wwmp 3249 7 BUN bun NN cord-015306-us58wwmp 3249 8 = = SYM cord-015306-us58wwmp 3249 9 150 150 CD cord-015306-us58wwmp 3249 10 mg mg NNP cord-015306-us58wwmp 3249 11 / / SYM cord-015306-us58wwmp 3249 12 dl dl NNP cord-015306-us58wwmp 3249 13 , , , cord-015306-us58wwmp 3249 14 Cr= Cr= NNP cord-015306-us58wwmp 3249 15 5 5 CD cord-015306-us58wwmp 3249 16 mg mg NNP cord-015306-us58wwmp 3249 17 / / SYM cord-015306-us58wwmp 3249 18 dl dl NN cord-015306-us58wwmp 3249 19 , , , cord-015306-us58wwmp 3249 20 uric uric NN cord-015306-us58wwmp 3249 21 acid acid NN cord-015306-us58wwmp 3249 22 = = NFP cord-015306-us58wwmp 3250 1 10 10 CD cord-015306-us58wwmp 3250 2 mg mg NNP cord-015306-us58wwmp 3250 3 / / SYM cord-015306-us58wwmp 3250 4 dl dl NNP cord-015306-us58wwmp 3250 5 , , , cord-015306-us58wwmp 3250 6 calcium= calcium= NNP cord-015306-us58wwmp 3250 7 4 4 CD cord-015306-us58wwmp 3250 8 mg mg NNP cord-015306-us58wwmp 3250 9 / / SYM cord-015306-us58wwmp 3250 10 dl dl NNP cord-015306-us58wwmp 3250 11 , , , cord-015306-us58wwmp 3250 12 phosphate phosphate NN cord-015306-us58wwmp 3250 13 = = NFP cord-015306-us58wwmp 3251 1 40 40 CD cord-015306-us58wwmp 3252 1 mg mg NNP cord-015306-us58wwmp 3252 2 / / SYM cord-015306-us58wwmp 3252 3 dl dl NNP cord-015306-us58wwmp 3252 4 , , , cord-015306-us58wwmp 3252 5 alkaline alkaline JJ cord-015306-us58wwmp 3252 6 phosphatase= phosphatase= NN cord-015306-us58wwmp 3252 7 1017 1017 CD cord-015306-us58wwmp 3252 8 , , , cord-015306-us58wwmp 3252 9 PTH= pth= ADD cord-015306-us58wwmp 3252 10 700 700 CD cord-015306-us58wwmp 3253 1 pm pm NNP cord-015306-us58wwmp 3253 2 / / SYM cord-015306-us58wwmp 3253 3 l l NNP cord-015306-us58wwmp 3253 4 , , , cord-015306-us58wwmp 3253 5 VITD= VITD= NNP cord-015306-us58wwmp 3253 6 21 21 CD cord-015306-us58wwmp 3253 7 mg mg NNP cord-015306-us58wwmp 3253 8 / / SYM cord-015306-us58wwmp 3253 9 ml ml NN cord-015306-us58wwmp 3253 10 . . . cord-015306-us58wwmp 3254 1 Calciphylaxis calciphylaxis NN cord-015306-us58wwmp 3254 2 process process NN cord-015306-us58wwmp 3254 3 started start VBD cord-015306-us58wwmp 3254 4 when when WRB cord-015306-us58wwmp 3254 5 she -PRON- PRP cord-015306-us58wwmp 3254 6 received receive VBD cord-015306-us58wwmp 3254 7 calcium calcium NN cord-015306-us58wwmp 3254 8 gluconate gluconate NNP cord-015306-us58wwmp 3254 9 IV IV NNP cord-015306-us58wwmp 3254 10 the the DT cord-015306-us58wwmp 3254 11 day day NN cord-015306-us58wwmp 3254 12 before before IN cord-015306-us58wwmp 3254 13 surgery surgery NN cord-015306-us58wwmp 3254 14 and and CC cord-015306-us58wwmp 3254 15 continued continue VBD cord-015306-us58wwmp 3254 16 progressively progressively RB cord-015306-us58wwmp 3254 17 when when WRB cord-015306-us58wwmp 3254 18 oral oral JJ cord-015306-us58wwmp 3254 19 calcium calcium NN cord-015306-us58wwmp 3254 20 carbonate carbonate NN cord-015306-us58wwmp 3254 21 and and CC cord-015306-us58wwmp 3254 22 oral oral JJ cord-015306-us58wwmp 3254 23 calcium calcium NN cord-015306-us58wwmp 3254 24 gluconate gluconate NN cord-015306-us58wwmp 3254 25 were be VBD cord-015306-us58wwmp 3254 26 given give VBN cord-015306-us58wwmp 3254 27 . . . cord-015306-us58wwmp 3255 1 Hourly hourly JJ cord-015306-us58wwmp 3255 2 peritoneal peritoneal JJ cord-015306-us58wwmp 3255 3 dialysis dialysis NN cord-015306-us58wwmp 3255 4 was be VBD cord-015306-us58wwmp 3255 5 started start VBN cord-015306-us58wwmp 3255 6 and and CC cord-015306-us58wwmp 3255 7 all all DT cord-015306-us58wwmp 3255 8 calcium calcium NN cord-015306-us58wwmp 3255 9 containing contain VBG cord-015306-us58wwmp 3255 10 medications medication NNS cord-015306-us58wwmp 3255 11 were be VBD cord-015306-us58wwmp 3255 12 stopped stop VBN cord-015306-us58wwmp 3255 13 . . . cord-015306-us58wwmp 3256 1 But but CC cord-015306-us58wwmp 3256 2 the the DT cord-015306-us58wwmp 3256 3 process process NN cord-015306-us58wwmp 3256 4 continued continue VBD cord-015306-us58wwmp 3256 5 progressively progressively RB cord-015306-us58wwmp 3256 6 . . . cord-015306-us58wwmp 3257 1 Surgical surgical JJ cord-015306-us58wwmp 3257 2 detriment detriment NN cord-015306-us58wwmp 3257 3 of of IN cord-015306-us58wwmp 3257 4 the the DT cord-015306-us58wwmp 3257 5 necrotic necrotic JJ cord-015306-us58wwmp 3257 6 tissue tissue NN cord-015306-us58wwmp 3257 7 of of IN cord-015306-us58wwmp 3257 8 right right JJ cord-015306-us58wwmp 3257 9 wrist wrist NN cord-015306-us58wwmp 3257 10 was be VBD cord-015306-us58wwmp 3257 11 done do VBN cord-015306-us58wwmp 3257 12 . . . cord-015306-us58wwmp 3258 1 Comfeel Comfeel NNP cord-015306-us58wwmp 3258 2 dressing dressing NN cord-015306-us58wwmp 3258 3 had have VBD cord-015306-us58wwmp 3258 4 no no DT cord-015306-us58wwmp 3258 5 effect effect NN cord-015306-us58wwmp 3258 6 and and CC cord-015306-us58wwmp 3258 7 the the DT cord-015306-us58wwmp 3258 8 circulation circulation NN cord-015306-us58wwmp 3258 9 of of IN cord-015306-us58wwmp 3258 10 tissue tissue NN cord-015306-us58wwmp 3258 11 was be VBD cord-015306-us58wwmp 3258 12 poor poor JJ cord-015306-us58wwmp 3258 13 . . . cord-015306-us58wwmp 3259 1 Therefore therefore RB cord-015306-us58wwmp 3259 2 the the DT cord-015306-us58wwmp 3259 3 left left JJ cord-015306-us58wwmp 3259 4 wrist wrist NN cord-015306-us58wwmp 3259 5 was be VBD cord-015306-us58wwmp 3259 6 kept keep VBN cord-015306-us58wwmp 3259 7 as as IN cord-015306-us58wwmp 3259 8 control control NN cord-015306-us58wwmp 3259 9 . . . cord-015306-us58wwmp 3260 1 Pamidronate Pamidronate NNP cord-015306-us58wwmp 3260 2 0.5 0.5 CD cord-015306-us58wwmp 3260 3 mg mg NNP cord-015306-us58wwmp 3260 4 / / SYM cord-015306-us58wwmp 3260 5 kg kg NNP cord-015306-us58wwmp 3260 6 / / SYM cord-015306-us58wwmp 3260 7 day day NN cord-015306-us58wwmp 3260 8 prescribed prescribe VBN cord-015306-us58wwmp 3260 9 for for IN cord-015306-us58wwmp 3260 10 6 6 CD cord-015306-us58wwmp 3260 11 days day NNS cord-015306-us58wwmp 3260 12 and and CC cord-015306-us58wwmp 3261 1 then then RB cord-015306-us58wwmp 3261 2 once once RB cord-015306-us58wwmp 3261 3 a a DT cord-015306-us58wwmp 3261 4 week week NN cord-015306-us58wwmp 3261 5 for for IN cord-015306-us58wwmp 3261 6 5 5 CD cord-015306-us58wwmp 3261 7 weeks week NNS cord-015306-us58wwmp 3261 8 . . . cord-015306-us58wwmp 3262 1 After after IN cord-015306-us58wwmp 3262 2 one one CD cord-015306-us58wwmp 3262 3 week week NN cord-015306-us58wwmp 3262 4 of of IN cord-015306-us58wwmp 3262 5 starting start VBG cord-015306-us58wwmp 3262 6 pamidronate pamidronate JJ cord-015306-us58wwmp 3262 7 skin skin NN cord-015306-us58wwmp 3262 8 lesion lesion NN cord-015306-us58wwmp 3262 9 began begin VBD cord-015306-us58wwmp 3262 10 to to TO cord-015306-us58wwmp 3262 11 heal heal VB cord-015306-us58wwmp 3262 12 , , , cord-015306-us58wwmp 3262 13 circulation circulation NN cord-015306-us58wwmp 3262 14 improved improve VBN cord-015306-us58wwmp 3262 15 and and CC cord-015306-us58wwmp 3262 16 after after IN cord-015306-us58wwmp 3262 17 six six CD cord-015306-us58wwmp 3262 18 weeks week NNS cord-015306-us58wwmp 3262 19 all all DT cord-015306-us58wwmp 3262 20 skin skin NN cord-015306-us58wwmp 3262 21 lesions lesion NNS cord-015306-us58wwmp 3262 22 completely completely RB cord-015306-us58wwmp 3262 23 recovered recover VBD cord-015306-us58wwmp 3262 24 . . . cord-015306-us58wwmp 3263 1 As as IN cord-015306-us58wwmp 3263 2 shown show VBN cord-015306-us58wwmp 3263 3 in in IN cord-015306-us58wwmp 3263 4 figure figure NN cord-015306-us58wwmp 3263 5 one one CD cord-015306-us58wwmp 3263 6 debridement debridement NN cord-015306-us58wwmp 3263 7 cause cause NN cord-015306-us58wwmp 3263 8 skin skin NN cord-015306-us58wwmp 3263 9 scar scar NN cord-015306-us58wwmp 3263 10 on on IN cord-015306-us58wwmp 3263 11 right right JJ cord-015306-us58wwmp 3263 12 wrist wrist NN cord-015306-us58wwmp 3263 13 . . . cord-015306-us58wwmp 3264 1 Conclusion conclusion NN cord-015306-us58wwmp 3264 2 : : : cord-015306-us58wwmp 3265 1 Pamidronate Pamidronate NNP cord-015306-us58wwmp 3265 2 is be VBZ cord-015306-us58wwmp 3265 3 effective effective JJ cord-015306-us58wwmp 3265 4 to to TO cord-015306-us58wwmp 3265 5 stop stop VB cord-015306-us58wwmp 3265 6 calciphylaxis calciphylaxis NN cord-015306-us58wwmp 3265 7 in in IN cord-015306-us58wwmp 3265 8 children child NNS cord-015306-us58wwmp 3265 9 with with IN cord-015306-us58wwmp 3265 10 advance advance JJ cord-015306-us58wwmp 3265 11 renal renal JJ cord-015306-us58wwmp 3265 12 insufficiency insufficiency NN cord-015306-us58wwmp 3265 13 and and CC cord-015306-us58wwmp 3265 14 severe severe JJ cord-015306-us58wwmp 3265 15 calcium calcium NN cord-015306-us58wwmp 3265 16 - - HYPH cord-015306-us58wwmp 3265 17 phosphate phosphate NN cord-015306-us58wwmp 3265 18 imbalance imbalance NN cord-015306-us58wwmp 3265 19 . . . cord-015306-us58wwmp 3266 1 Medical medical JJ cord-015306-us58wwmp 3266 2 or or CC cord-015306-us58wwmp 3266 3 surgical surgical JJ cord-015306-us58wwmp 3266 4 debridement debridement NN cord-015306-us58wwmp 3266 5 are be VBP cord-015306-us58wwmp 3266 6 not not RB cord-015306-us58wwmp 3266 7 suggested suggest VBN cord-015306-us58wwmp 3266 8 and and CC cord-015306-us58wwmp 3266 9 lesions lesion NNS cord-015306-us58wwmp 3266 10 will will MD cord-015306-us58wwmp 3266 11 recover recover VB cord-015306-us58wwmp 3266 12 without without IN cord-015306-us58wwmp 3266 13 scar scar NN cord-015306-us58wwmp 3266 14 by by IN cord-015306-us58wwmp 3266 15 pamidronate pamidronate NNP cord-015306-us58wwmp 3266 16 Objective Objective NNP cord-015306-us58wwmp 3266 17 : : : cord-015306-us58wwmp 3266 18 Fibroblast fibroblast JJ cord-015306-us58wwmp 3266 19 growth growth NN cord-015306-us58wwmp 3266 20 factor factor NN cord-015306-us58wwmp 3266 21 23 23 CD cord-015306-us58wwmp 3266 22 ( ( -LRB- cord-015306-us58wwmp 3266 23 FGF23 fgf23 NN cord-015306-us58wwmp 3266 24 ) ) -RRB- cord-015306-us58wwmp 3266 25 is be VBZ cord-015306-us58wwmp 3266 26 a a DT cord-015306-us58wwmp 3266 27 key key JJ cord-015306-us58wwmp 3266 28 player player NN cord-015306-us58wwmp 3266 29 in in IN cord-015306-us58wwmp 3266 30 kidney kidney NN cord-015306-us58wwmp 3266 31 - - HYPH cord-015306-us58wwmp 3266 32 bone bone NN cord-015306-us58wwmp 3266 33 axis axis NN cord-015306-us58wwmp 3266 34 and and CC cord-015306-us58wwmp 3266 35 regulation regulation NN cord-015306-us58wwmp 3266 36 of of IN cord-015306-us58wwmp 3266 37 calcium calcium NN cord-015306-us58wwmp 3266 38 and and CC cord-015306-us58wwmp 3266 39 phosphate phosphate NN cord-015306-us58wwmp 3266 40 homeostasis homeostasis NN cord-015306-us58wwmp 3266 41 . . . cord-015306-us58wwmp 3267 1 Most Most JJS cord-015306-us58wwmp 3267 2 of of IN cord-015306-us58wwmp 3267 3 the the DT cord-015306-us58wwmp 3267 4 recent recent JJ cord-015306-us58wwmp 3267 5 research research NN cord-015306-us58wwmp 3267 6 has have VBZ cord-015306-us58wwmp 3267 7 focused focus VBN cord-015306-us58wwmp 3267 8 on on IN cord-015306-us58wwmp 3267 9 FGF23 fgf23 NN cord-015306-us58wwmp 3267 10 in in IN cord-015306-us58wwmp 3267 11 chronic chronic JJ cord-015306-us58wwmp 3267 12 kidney kidney NN cord-015306-us58wwmp 3267 13 disease disease NN cord-015306-us58wwmp 3267 14 and and CC cord-015306-us58wwmp 3267 15 there there EX cord-015306-us58wwmp 3267 16 is be VBZ cord-015306-us58wwmp 3267 17 paucity paucity NN cord-015306-us58wwmp 3267 18 of of IN cord-015306-us58wwmp 3267 19 data datum NNS cord-015306-us58wwmp 3267 20 in in IN cord-015306-us58wwmp 3267 21 healthy healthy JJ cord-015306-us58wwmp 3267 22 children child NNS cord-015306-us58wwmp 3267 23 . . . cord-015306-us58wwmp 3268 1 Hence hence RB cord-015306-us58wwmp 3268 2 we -PRON- PRP cord-015306-us58wwmp 3268 3 initiated initiate VBD cord-015306-us58wwmp 3268 4 a a DT cord-015306-us58wwmp 3268 5 study study NN cord-015306-us58wwmp 3268 6 on on IN cord-015306-us58wwmp 3268 7 the the DT cord-015306-us58wwmp 3268 8 various various JJ cord-015306-us58wwmp 3268 9 biomarkers biomarker NNS cord-015306-us58wwmp 3268 10 of of IN cord-015306-us58wwmp 3268 11 calcium calcium NN cord-015306-us58wwmp 3268 12 - - HYPH cord-015306-us58wwmp 3268 13 phosphate phosphate NN cord-015306-us58wwmp 3268 14 metabolism metabolism NN cord-015306-us58wwmp 3268 15 including include VBG cord-015306-us58wwmp 3268 16 FGF23 fgf23 NN cord-015306-us58wwmp 3268 17 in in IN cord-015306-us58wwmp 3268 18 healthy healthy JJ cord-015306-us58wwmp 3268 19 children child NNS cord-015306-us58wwmp 3268 20 and and CC cord-015306-us58wwmp 3268 21 present present VB cord-015306-us58wwmp 3268 22 here here RB cord-015306-us58wwmp 3268 23 the the DT cord-015306-us58wwmp 3268 24 interim interim JJ cord-015306-us58wwmp 3268 25 report report NN cord-015306-us58wwmp 3268 26 of of IN cord-015306-us58wwmp 3268 27 our -PRON- PRP$ cord-015306-us58wwmp 3268 28 findings finding NNS cord-015306-us58wwmp 3268 29 as as IN cord-015306-us58wwmp 3268 30 of of IN cord-015306-us58wwmp 3268 31 now now RB cord-015306-us58wwmp 3268 32 . . . cord-015306-us58wwmp 3269 1 Methods method NNS cord-015306-us58wwmp 3269 2 : : : cord-015306-us58wwmp 3270 1 A a DT cord-015306-us58wwmp 3270 2 total total JJ cord-015306-us58wwmp 3270 3 100 100 CD cord-015306-us58wwmp 3270 4 healthy healthy JJ cord-015306-us58wwmp 3270 5 school school NN cord-015306-us58wwmp 3270 6 children child NNS cord-015306-us58wwmp 3270 7 and and CC cord-015306-us58wwmp 3270 8 adolescents adolescent NNS cord-015306-us58wwmp 3270 9 aged age VBN cord-015306-us58wwmp 3270 10 6 6 CD cord-015306-us58wwmp 3270 11 - - SYM cord-015306-us58wwmp 3270 12 16 16 CD cord-015306-us58wwmp 3270 13 years year NNS cord-015306-us58wwmp 3270 14 , , , cord-015306-us58wwmp 3270 15 were be VBD cord-015306-us58wwmp 3270 16 enrolled enrol VBN cord-015306-us58wwmp 3270 17 in in IN cord-015306-us58wwmp 3270 18 this this DT cord-015306-us58wwmp 3270 19 cross cross JJ cord-015306-us58wwmp 3270 20 - - JJ cord-015306-us58wwmp 3270 21 sectional sectional JJ cord-015306-us58wwmp 3270 22 study study NN cord-015306-us58wwmp 3270 23 , , , cord-015306-us58wwmp 3270 24 after after IN cord-015306-us58wwmp 3270 25 a a DT cord-015306-us58wwmp 3270 26 written write VBN cord-015306-us58wwmp 3270 27 consent consent NN cord-015306-us58wwmp 3270 28 from from IN cord-015306-us58wwmp 3270 29 their -PRON- PRP$ cord-015306-us58wwmp 3270 30 parents parent NNS cord-015306-us58wwmp 3270 31 . . . cord-015306-us58wwmp 3271 1 Height height NN cord-015306-us58wwmp 3271 2 , , , cord-015306-us58wwmp 3271 3 weight weight NN cord-015306-us58wwmp 3271 4 and and CC cord-015306-us58wwmp 3271 5 pubertal pubertal JJ cord-015306-us58wwmp 3271 6 staging staging NN cord-015306-us58wwmp 3271 7 were be VBD cord-015306-us58wwmp 3271 8 assessed assess VBN cord-015306-us58wwmp 3271 9 . . . cord-015306-us58wwmp 3272 1 Blood blood NN cord-015306-us58wwmp 3272 2 was be VBD cord-015306-us58wwmp 3272 3 collected collect VBN cord-015306-us58wwmp 3272 4 and and CC cord-015306-us58wwmp 3272 5 calcium calcium NN cord-015306-us58wwmp 3272 6 , , , cord-015306-us58wwmp 3272 7 phosphate phosphate NN cord-015306-us58wwmp 3272 8 , , , cord-015306-us58wwmp 3272 9 PTH PTH NNP cord-015306-us58wwmp 3272 10 and and CC cord-015306-us58wwmp 3272 11 vitamin vitamin NN cord-015306-us58wwmp 3272 12 D D NNP cord-015306-us58wwmp 3272 13 were be VBD cord-015306-us58wwmp 3272 14 estimated estimate VBN cord-015306-us58wwmp 3272 15 by by IN cord-015306-us58wwmp 3272 16 standard standard JJ cord-015306-us58wwmp 3272 17 methods method NNS cord-015306-us58wwmp 3272 18 . . . cord-015306-us58wwmp 3273 1 Plasma plasma NN cord-015306-us58wwmp 3273 2 C c NN cord-015306-us58wwmp 3273 3 - - HYPH cord-015306-us58wwmp 3273 4 terminal terminal NN cord-015306-us58wwmp 3273 5 fragment fragment NN cord-015306-us58wwmp 3273 6 of of IN cord-015306-us58wwmp 3273 7 FGF23 FGF23 NNP cord-015306-us58wwmp 3273 8 was be VBD cord-015306-us58wwmp 3273 9 quantitated quantitate VBN cord-015306-us58wwmp 3273 10 using use VBG cord-015306-us58wwmp 3273 11 a a DT cord-015306-us58wwmp 3273 12 commercial commercial JJ cord-015306-us58wwmp 3273 13 ELISA ELISA NNP cord-015306-us58wwmp 3273 14 kit kit NN cord-015306-us58wwmp 3273 15 ( ( -LRB- cord-015306-us58wwmp 3273 16 Immutopics Immutopics NNP cord-015306-us58wwmp 3273 17 , , , cord-015306-us58wwmp 3273 18 USA USA NNP cord-015306-us58wwmp 3273 19 ) ) -RRB- cord-015306-us58wwmp 3273 20 . . . cord-015306-us58wwmp 3274 1 Three three CD cord-015306-us58wwmp 3274 2 day day NN cord-015306-us58wwmp 3274 3 dietary dietary JJ cord-015306-us58wwmp 3274 4 recall recall NN cord-015306-us58wwmp 3274 5 was be VBD cord-015306-us58wwmp 3274 6 done do VBN cord-015306-us58wwmp 3274 7 to to TO cord-015306-us58wwmp 3274 8 calculate calculate VB cord-015306-us58wwmp 3274 9 mean mean JJ cord-015306-us58wwmp 3274 10 daily daily JJ cord-015306-us58wwmp 3274 11 calcium calcium NN cord-015306-us58wwmp 3274 12 , , , cord-015306-us58wwmp 3274 13 phosphate phosphate NN cord-015306-us58wwmp 3274 14 and and CC cord-015306-us58wwmp 3274 15 protein protein NN cord-015306-us58wwmp 3274 16 intake intake NN cord-015306-us58wwmp 3274 17 . . . cord-015306-us58wwmp 3275 1 Results result NNS cord-015306-us58wwmp 3275 2 : : : cord-015306-us58wwmp 3276 1 Of of IN cord-015306-us58wwmp 3276 2 the the DT cord-015306-us58wwmp 3276 3 100 100 CD cord-015306-us58wwmp 3276 4 children child NNS cord-015306-us58wwmp 3276 5 enrolled enrol VBD cord-015306-us58wwmp 3276 6 60 60 CD cord-015306-us58wwmp 3276 7 % % NN cord-015306-us58wwmp 3276 8 were be VBD cord-015306-us58wwmp 3276 9 males male NNS cord-015306-us58wwmp 3276 10 . . . cord-015306-us58wwmp 3277 1 The the DT cord-015306-us58wwmp 3277 2 mean mean JJ cord-015306-us58wwmp 3277 3 age age NN cord-015306-us58wwmp 3277 4 was be VBD cord-015306-us58wwmp 3277 5 12.3 12.3 CD cord-015306-us58wwmp 3277 6 yrs yr NNS cord-015306-us58wwmp 3277 7 , , , cord-015306-us58wwmp 3278 1 mean mean VB cord-015306-us58wwmp 3278 2 height height NNP cord-015306-us58wwmp 3278 3 was144 was144 NNP cord-015306-us58wwmp 3278 4 cms cms NNP cord-015306-us58wwmp 3278 5 and and CC cord-015306-us58wwmp 3278 6 mean mean VB cord-015306-us58wwmp 3278 7 weight weight NN cord-015306-us58wwmp 3278 8 was be VBD cord-015306-us58wwmp 3278 9 34kgs 34kgs JJ cord-015306-us58wwmp 3278 10 . . . cord-015306-us58wwmp 3279 1 The the DT cord-015306-us58wwmp 3279 2 mean mean JJ cord-015306-us58wwmp 3279 3 blood blood NN cord-015306-us58wwmp 3279 4 biochemistry biochemistry NN cord-015306-us58wwmp 3279 5 values value NNS cord-015306-us58wwmp 3279 6 of of IN cord-015306-us58wwmp 3279 7 the the DT cord-015306-us58wwmp 3279 8 children child NNS cord-015306-us58wwmp 3279 9 tested test VBN cord-015306-us58wwmp 3279 10 so so RB cord-015306-us58wwmp 3279 11 far far RB cord-015306-us58wwmp 3279 12 for for IN cord-015306-us58wwmp 3279 13 Ca Ca NNP cord-015306-us58wwmp 3279 14 , , , cord-015306-us58wwmp 3279 15 P P NNP cord-015306-us58wwmp 3279 16 , , , cord-015306-us58wwmp 3279 17 PTH PTH NNP cord-015306-us58wwmp 3279 18 and and CC cord-015306-us58wwmp 3279 19 vitamin vitamin NN cord-015306-us58wwmp 3279 20 D d NN cord-015306-us58wwmp 3279 21 shown show VBN cord-015306-us58wwmp 3279 22 in in IN cord-015306-us58wwmp 3279 23 table table NN cord-015306-us58wwmp 3279 24 1 1 CD cord-015306-us58wwmp 3279 25 . . . cord-015306-us58wwmp 3280 1 The the DT cord-015306-us58wwmp 3280 2 parameters parameter NNS cord-015306-us58wwmp 3280 3 of of IN cord-015306-us58wwmp 3280 4 the the DT cord-015306-us58wwmp 3280 5 children child NNS cord-015306-us58wwmp 3280 6 were be VBD cord-015306-us58wwmp 3280 7 normal normal JJ cord-015306-us58wwmp 3280 8 for for IN cord-015306-us58wwmp 3280 9 their -PRON- PRP$ cord-015306-us58wwmp 3280 10 respective respective JJ cord-015306-us58wwmp 3280 11 ages age NNS cord-015306-us58wwmp 3280 12 however however RB cord-015306-us58wwmp 3280 13 FGF23 fgf23 NN cord-015306-us58wwmp 3280 14 levels level NNS cord-015306-us58wwmp 3280 15 were be VBD cord-015306-us58wwmp 3280 16 found find VBN cord-015306-us58wwmp 3280 17 to to TO cord-015306-us58wwmp 3280 18 be be VB cord-015306-us58wwmp 3280 19 lower low JJR cord-015306-us58wwmp 3280 20 compared compare VBN cord-015306-us58wwmp 3280 21 to to IN cord-015306-us58wwmp 3280 22 reports report NNS cord-015306-us58wwmp 3280 23 in in IN cord-015306-us58wwmp 3280 24 literature literature NN cord-015306-us58wwmp 3280 25 . . . cord-015306-us58wwmp 3281 1 Conclusions conclusion NNS cord-015306-us58wwmp 3281 2 : : : cord-015306-us58wwmp 3282 1 From from IN cord-015306-us58wwmp 3282 2 the the DT cord-015306-us58wwmp 3282 3 results result NNS cord-015306-us58wwmp 3282 4 available available JJ cord-015306-us58wwmp 3282 5 as as IN cord-015306-us58wwmp 3282 6 of of IN cord-015306-us58wwmp 3282 7 now now RB cord-015306-us58wwmp 3282 8 all all DT cord-015306-us58wwmp 3282 9 of of IN cord-015306-us58wwmp 3282 10 the the DT cord-015306-us58wwmp 3282 11 children child NNS cord-015306-us58wwmp 3282 12 had have VBD cord-015306-us58wwmp 3282 13 normal normal JJ cord-015306-us58wwmp 3282 14 biochemistry biochemistry NN cord-015306-us58wwmp 3282 15 for for IN cord-015306-us58wwmp 3282 16 their -PRON- PRP$ cord-015306-us58wwmp 3282 17 ages age NNS cord-015306-us58wwmp 3282 18 . . . cord-015306-us58wwmp 3283 1 The the DT cord-015306-us58wwmp 3283 2 FGF23 fgf23 NN cord-015306-us58wwmp 3283 3 levels level NNS cord-015306-us58wwmp 3283 4 were be VBD cord-015306-us58wwmp 3283 5 found find VBN cord-015306-us58wwmp 3283 6 to to TO cord-015306-us58wwmp 3283 7 be be VB cord-015306-us58wwmp 3283 8 lower low JJR cord-015306-us58wwmp 3283 9 than than IN cord-015306-us58wwmp 3283 10 reports report NNS cord-015306-us58wwmp 3283 11 in in IN cord-015306-us58wwmp 3283 12 the the DT cord-015306-us58wwmp 3283 13 literature literature NN cord-015306-us58wwmp 3283 14 . . . cord-015306-us58wwmp 3284 1 Whether whether IN cord-015306-us58wwmp 3284 2 it -PRON- PRP cord-015306-us58wwmp 3284 3 can can MD cord-015306-us58wwmp 3284 4 be be VB cord-015306-us58wwmp 3284 5 attributed attribute VBN cord-015306-us58wwmp 3284 6 to to IN cord-015306-us58wwmp 3284 7 the the DT cord-015306-us58wwmp 3284 8 dietary dietary JJ cord-015306-us58wwmp 3284 9 differences difference NNS cord-015306-us58wwmp 3284 10 from from IN cord-015306-us58wwmp 3284 11 the the DT cord-015306-us58wwmp 3284 12 children child NNS cord-015306-us58wwmp 3284 13 of of IN cord-015306-us58wwmp 3284 14 the the DT cord-015306-us58wwmp 3284 15 west west NNP cord-015306-us58wwmp 3284 16 needs need VBZ cord-015306-us58wwmp 3284 17 further further JJ cord-015306-us58wwmp 3284 18 investigation investigation NN cord-015306-us58wwmp 3284 19 . . . cord-015306-us58wwmp 3285 1 Testing testing NN cord-015306-us58wwmp 3285 2 of of IN cord-015306-us58wwmp 3285 3 the the DT cord-015306-us58wwmp 3285 4 entire entire JJ cord-015306-us58wwmp 3285 5 cohort cohort NN cord-015306-us58wwmp 3285 6 will will MD cord-015306-us58wwmp 3285 7 reveal reveal VB cord-015306-us58wwmp 3285 8 if if IN cord-015306-us58wwmp 3285 9 this this DT cord-015306-us58wwmp 3285 10 lower low JJR cord-015306-us58wwmp 3285 11 FGF23 fgf23 NN cord-015306-us58wwmp 3285 12 is be VBZ cord-015306-us58wwmp 3285 13 a a DT cord-015306-us58wwmp 3285 14 universal universal JJ cord-015306-us58wwmp 3285 15 phenomenon phenomenon NN cord-015306-us58wwmp 3285 16 among among IN cord-015306-us58wwmp 3285 17 all all DT cord-015306-us58wwmp 3285 18 children child NNS cord-015306-us58wwmp 3285 19 in in IN cord-015306-us58wwmp 3285 20 our -PRON- PRP$ cord-015306-us58wwmp 3285 21 study study NN cord-015306-us58wwmp 3285 22 . . . cord-015306-us58wwmp 3286 1 On on IN cord-015306-us58wwmp 3286 2 the the DT cord-015306-us58wwmp 3286 3 contrary contrary NN cord-015306-us58wwmp 3286 4 , , , cord-015306-us58wwmp 3286 5 all all DT cord-015306-us58wwmp 3286 6 DXA DXA NNP cord-015306-us58wwmp 3286 7 parameters parameter NNS cord-015306-us58wwmp 3286 8 showed show VBD cord-015306-us58wwmp 3286 9 a a DT cord-015306-us58wwmp 3286 10 decreased decreased NN cord-015306-us58wwmp 3286 11 in in IN cord-015306-us58wwmp 3286 12 their -PRON- PRP$ cord-015306-us58wwmp 3286 13 mean mean JJ cord-015306-us58wwmp 3286 14 Zscore Zscore NNP cord-015306-us58wwmp 3286 15 BMD bmd NN cord-015306-us58wwmp 3286 16 values value NNS cord-015306-us58wwmp 3286 17 that that WDT cord-015306-us58wwmp 3286 18 reached reach VBD cord-015306-us58wwmp 3286 19 statistically statistically RB cord-015306-us58wwmp 3286 20 significance significance NN cord-015306-us58wwmp 3286 21 . . . cord-015306-us58wwmp 3287 1 Finally finally RB cord-015306-us58wwmp 3287 2 , , , cord-015306-us58wwmp 3287 3 multivariate multivariate JJ cord-015306-us58wwmp 3287 4 stepwise stepwise JJ cord-015306-us58wwmp 3287 5 regression regression NN cord-015306-us58wwmp 3287 6 analyses analysis NNS cord-015306-us58wwmp 3287 7 showed show VBD cord-015306-us58wwmp 3287 8 that that IN cord-015306-us58wwmp 3287 9 estimated estimate VBN cord-015306-us58wwmp 3287 10 glomerular glomerular JJ cord-015306-us58wwmp 3287 11 filtration filtration NN cord-015306-us58wwmp 3287 12 rate rate NN cord-015306-us58wwmp 3287 13 at at IN cord-015306-us58wwmp 3287 14 the the DT cord-015306-us58wwmp 3287 15 beginning beginning NN cord-015306-us58wwmp 3287 16 of of IN cord-015306-us58wwmp 3287 17 the the DT cord-015306-us58wwmp 3287 18 study study NN cord-015306-us58wwmp 3287 19 was be VBD cord-015306-us58wwmp 3287 20 the the DT cord-015306-us58wwmp 3287 21 best good JJS cord-015306-us58wwmp 3287 22 predictor predictor NN cord-015306-us58wwmp 3287 23 of of IN cord-015306-us58wwmp 3287 24 the the DT cord-015306-us58wwmp 3287 25 difference difference NN cord-015306-us58wwmp 3287 26 in in IN cord-015306-us58wwmp 3287 27 BMD BMD NNP cord-015306-us58wwmp 3287 28 Z Z NNP cord-015306-us58wwmp 3287 29 - - HYPH cord-015306-us58wwmp 3287 30 scores score NNS cord-015306-us58wwmp 3287 31 measured measure VBN cord-015306-us58wwmp 3287 32 at at IN cord-015306-us58wwmp 3287 33 lumbar lumbar NN cord-015306-us58wwmp 3287 34 spine spine NN cord-015306-us58wwmp 3287 35 . . . cord-015306-us58wwmp 3288 1 Additionally additionally RB cord-015306-us58wwmp 3288 2 , , , cord-015306-us58wwmp 3288 3 values value NNS cord-015306-us58wwmp 3288 4 of of IN cord-015306-us58wwmp 3288 5 iPTH ipth NN cord-015306-us58wwmp 3288 6 at at IN cord-015306-us58wwmp 3288 7 the the DT cord-015306-us58wwmp 3288 8 beginning beginning NN cord-015306-us58wwmp 3288 9 of of IN cord-015306-us58wwmp 3288 10 the the DT cord-015306-us58wwmp 3288 11 study study NN cord-015306-us58wwmp 3288 12 and and CC cord-015306-us58wwmp 3288 13 the the DT cord-015306-us58wwmp 3288 14 change change NN cord-015306-us58wwmp 3288 15 of of IN cord-015306-us58wwmp 3288 16 iPTH iPTH NNP cord-015306-us58wwmp 3288 17 throughout throughout IN cord-015306-us58wwmp 3288 18 the the DT cord-015306-us58wwmp 3288 19 study study NN cord-015306-us58wwmp 3288 20 predicted predict VBD cord-015306-us58wwmp 3288 21 the the DT cord-015306-us58wwmp 3288 22 72.3 72.3 CD cord-015306-us58wwmp 3288 23 % % NN cord-015306-us58wwmp 3288 24 of of IN cord-015306-us58wwmp 3288 25 the the DT cord-015306-us58wwmp 3288 26 difference difference NN cord-015306-us58wwmp 3288 27 in in IN cord-015306-us58wwmp 3288 28 Z z NN cord-015306-us58wwmp 3288 29 - - HYPH cord-015306-us58wwmp 3288 30 score score NN cord-015306-us58wwmp 3288 31 of of IN cord-015306-us58wwmp 3288 32 SOS SOS NNP cord-015306-us58wwmp 3288 33 measured measure VBN cord-015306-us58wwmp 3288 34 at at IN cord-015306-us58wwmp 3288 35 radius radius NN cord-015306-us58wwmp 3288 36 with with IN cord-015306-us58wwmp 3288 37 an an DT cord-015306-us58wwmp 3288 38 inverse inverse JJ cord-015306-us58wwmp 3288 39 relationship relationship NN cord-015306-us58wwmp 3288 40 . . . cord-015306-us58wwmp 3289 1 Conclusion conclusion NN cord-015306-us58wwmp 3289 2 : : : cord-015306-us58wwmp 3290 1 The the DT cord-015306-us58wwmp 3290 2 use use NN cord-015306-us58wwmp 3290 3 of of IN cord-015306-us58wwmp 3290 4 two two CD cord-015306-us58wwmp 3290 5 different different JJ cord-015306-us58wwmp 3290 6 techniques technique NNS cord-015306-us58wwmp 3290 7 have have VBP cord-015306-us58wwmp 3290 8 shown show VBN cord-015306-us58wwmp 3290 9 bipolar bipolar JJ cord-015306-us58wwmp 3290 10 changes change NNS cord-015306-us58wwmp 3290 11 of of IN cord-015306-us58wwmp 3290 12 bone bone NN cord-015306-us58wwmp 3290 13 properties property NNS cord-015306-us58wwmp 3290 14 after after IN cord-015306-us58wwmp 3290 15 renal renal JJ cord-015306-us58wwmp 3290 16 transplantation transplantation NN cord-015306-us58wwmp 3290 17 . . . cord-015306-us58wwmp 3291 1 Reversal reversal NN cord-015306-us58wwmp 3291 2 of of IN cord-015306-us58wwmp 3291 3 renal renal JJ cord-015306-us58wwmp 3291 4 osteodystrophy osteodystrophy NN cord-015306-us58wwmp 3291 5 and and CC cord-015306-us58wwmp 3291 6 consequently consequently RB cord-015306-us58wwmp 3291 7 correction correction NN cord-015306-us58wwmp 3291 8 of of IN cord-015306-us58wwmp 3291 9 many many JJ cord-015306-us58wwmp 3291 10 of of IN cord-015306-us58wwmp 3291 11 the the DT cord-015306-us58wwmp 3291 12 underlying underlying JJ cord-015306-us58wwmp 3291 13 metabolic metabolic JJ cord-015306-us58wwmp 3291 14 abnormalities abnormality NNS cord-015306-us58wwmp 3291 15 , , , cord-015306-us58wwmp 3291 16 mainly mainly RB cord-015306-us58wwmp 3291 17 normalization normalization NN cord-015306-us58wwmp 3291 18 of of IN cord-015306-us58wwmp 3291 19 iPTH iPTH NNP cord-015306-us58wwmp 3291 20 , , , cord-015306-us58wwmp 3291 21 strengths strength NNS cord-015306-us58wwmp 3291 22 cortical cortical JJ cord-015306-us58wwmp 3291 23 bone bone NN cord-015306-us58wwmp 3291 24 as as IN cord-015306-us58wwmp 3291 25 this this DT cord-015306-us58wwmp 3291 26 is be VBZ cord-015306-us58wwmp 3291 27 best well RBS cord-015306-us58wwmp 3291 28 illustrated illustrate VBN cord-015306-us58wwmp 3291 29 by by IN cord-015306-us58wwmp 3291 30 QUS QUS NNP cord-015306-us58wwmp 3291 31 assessment assessment NN cord-015306-us58wwmp 3291 32 . . . cord-015306-us58wwmp 3292 1 However however RB cord-015306-us58wwmp 3292 2 , , , cord-015306-us58wwmp 3292 3 reduction reduction NN cord-015306-us58wwmp 3292 4 in in IN cord-015306-us58wwmp 3292 5 BMD BMD NNP cord-015306-us58wwmp 3292 6 , , , cord-015306-us58wwmp 3292 7 is be VBZ cord-015306-us58wwmp 3292 8 predominantly predominantly RB cord-015306-us58wwmp 3292 9 considered consider VBN cord-015306-us58wwmp 3292 10 as as IN cord-015306-us58wwmp 3292 11 an an DT cord-015306-us58wwmp 3292 12 adverse adverse JJ cord-015306-us58wwmp 3292 13 effect effect NN cord-015306-us58wwmp 3292 14 of of IN cord-015306-us58wwmp 3292 15 steroid steroid NN cord-015306-us58wwmp 3292 16 immunosuppression immunosuppression NN cord-015306-us58wwmp 3292 17 . . . cord-015306-us58wwmp 3293 1 age age NN cord-015306-us58wwmp 3293 2 3.3 3.3 CD cord-015306-us58wwmp 3293 3 yr yr NN cord-015306-us58wwmp 3293 4 ) ) -RRB- cord-015306-us58wwmp 3293 5 ( ( -LRB- cord-015306-us58wwmp 3293 6 group group NN cord-015306-us58wwmp 3293 7 1 1 CD cord-015306-us58wwmp 3293 8 ) ) -RRB- cord-015306-us58wwmp 3294 1 , , , cord-015306-us58wwmp 3294 2 33 33 CD cord-015306-us58wwmp 3294 3 patients patient NNS cord-015306-us58wwmp 3294 4 with with IN cord-015306-us58wwmp 3294 5 CKD CKD NNP cord-015306-us58wwmp 3294 6 stage stage NN cord-015306-us58wwmp 3294 7 5 5 CD cord-015306-us58wwmp 3294 8 on on IN cord-015306-us58wwmp 3294 9 PD PD NNP cord-015306-us58wwmp 3294 10 or or CC cord-015306-us58wwmp 3294 11 Hemo Hemo NNP cord-015306-us58wwmp 3294 12 ( ( -LRB- cord-015306-us58wwmp 3294 13 mean mean VB cord-015306-us58wwmp 3294 14 age age NN cord-015306-us58wwmp 3294 15 9 9 CD cord-015306-us58wwmp 3294 16 yr yr NN cord-015306-us58wwmp 3294 17 , , , cord-015306-us58wwmp 3294 18 mean mean JJ cord-015306-us58wwmp 3294 19 time time NN cord-015306-us58wwmp 3294 20 on on IN cord-015306-us58wwmp 3294 21 dialysis dialysis NN cord-015306-us58wwmp 3294 22 2 2 CD cord-015306-us58wwmp 3294 23 yr yr NN cord-015306-us58wwmp 3294 24 ) ) -RRB- cord-015306-us58wwmp 3295 1 ( ( -LRB- cord-015306-us58wwmp 3295 2 group group NN cord-015306-us58wwmp 3295 3 2 2 CD cord-015306-us58wwmp 3295 4 ) ) -RRB- cord-015306-us58wwmp 3295 5 and and CC cord-015306-us58wwmp 3295 6 29 29 CD cord-015306-us58wwmp 3295 7 patients patient NNS cord-015306-us58wwmp 3295 8 with with IN cord-015306-us58wwmp 3295 9 CKD CKD NNP cord-015306-us58wwmp 3295 10 stages stage VBZ cord-015306-us58wwmp 3295 11 2 2 CD cord-015306-us58wwmp 3295 12 - - SYM cord-015306-us58wwmp 3295 13 4 4 CD cord-015306-us58wwmp 3296 1 ( ( -LRB- cord-015306-us58wwmp 3296 2 mean mean UH cord-015306-us58wwmp 3296 3 age age NN cord-015306-us58wwmp 3296 4 7 7 CD cord-015306-us58wwmp 3296 5 yr yr NN cord-015306-us58wwmp 3296 6 , , , cord-015306-us58wwmp 3296 7 mean mean VB cord-015306-us58wwmp 3296 8 GFR GFR NNP cord-015306-us58wwmp 3296 9 37 37 CD cord-015306-us58wwmp 3296 10 ml ml NNS cord-015306-us58wwmp 3296 11 / / SYM cord-015306-us58wwmp 3296 12 min/1.73 min/1.73 JJ cord-015306-us58wwmp 3296 13 m m CD cord-015306-us58wwmp 3296 14 2 2 CD cord-015306-us58wwmp 3296 15 ) ) -RRB- cord-015306-us58wwmp 3297 1 ( ( -LRB- cord-015306-us58wwmp 3297 2 group group NN cord-015306-us58wwmp 3297 3 3 3 CD cord-015306-us58wwmp 3297 4 ) ) -RRB- cord-015306-us58wwmp 3297 5 . . . cord-015306-us58wwmp 3298 1 25OHD 25ohd CD cord-015306-us58wwmp 3298 2 levels level NNS cord-015306-us58wwmp 3298 3 were be VBD cord-015306-us58wwmp 3298 4 deficient deficient JJ cord-015306-us58wwmp 3298 5 in in IN cord-015306-us58wwmp 3298 6 20 20 CD cord-015306-us58wwmp 3298 7 % % NN cord-015306-us58wwmp 3298 8 and and CC cord-015306-us58wwmp 3298 9 insufficient insufficient JJ cord-015306-us58wwmp 3298 10 in in IN cord-015306-us58wwmp 3298 11 35 35 CD cord-015306-us58wwmp 3298 12 % % NN cord-015306-us58wwmp 3298 13 of of IN cord-015306-us58wwmp 3298 14 the the DT cord-015306-us58wwmp 3298 15 group group NN cord-015306-us58wwmp 3298 16 1 1 CD cord-015306-us58wwmp 3298 17 patients patient NNS cord-015306-us58wwmp 3298 18 , , , cord-015306-us58wwmp 3298 19 48 48 CD cord-015306-us58wwmp 3298 20 % % NN cord-015306-us58wwmp 3298 21 were be VBD cord-015306-us58wwmp 3298 22 deficient deficient JJ cord-015306-us58wwmp 3298 23 and and CC cord-015306-us58wwmp 3298 24 15 15 CD cord-015306-us58wwmp 3298 25 % % NN cord-015306-us58wwmp 3298 26 were be VBD cord-015306-us58wwmp 3298 27 insufficient insufficient JJ cord-015306-us58wwmp 3298 28 in in IN cord-015306-us58wwmp 3298 29 group group NN cord-015306-us58wwmp 3298 30 2 2 CD cord-015306-us58wwmp 3298 31 , , , cord-015306-us58wwmp 3298 32 and and CC cord-015306-us58wwmp 3298 33 7 7 CD cord-015306-us58wwmp 3298 34 % % NN cord-015306-us58wwmp 3298 35 were be VBD cord-015306-us58wwmp 3298 36 deficient deficient JJ cord-015306-us58wwmp 3298 37 and and CC cord-015306-us58wwmp 3298 38 17 17 CD cord-015306-us58wwmp 3298 39 % % NN cord-015306-us58wwmp 3298 40 were be VBD cord-015306-us58wwmp 3298 41 insufficient insufficient JJ cord-015306-us58wwmp 3298 42 in in IN cord-015306-us58wwmp 3298 43 group group NN cord-015306-us58wwmp 3298 44 3 3 CD cord-015306-us58wwmp 3298 45 . . . cord-015306-us58wwmp 3299 1 Results result NNS cord-015306-us58wwmp 3299 2 : : : cord-015306-us58wwmp 3300 1 Intact Intact NNP cord-015306-us58wwmp 3300 2 PTH PTH NNP cord-015306-us58wwmp 3300 3 ( ( -LRB- cord-015306-us58wwmp 3300 4 iPTH iPTH NNP cord-015306-us58wwmp 3300 5 ) ) -RRB- cord-015306-us58wwmp 3300 6 was be VBD cord-015306-us58wwmp 3300 7 above above IN cord-015306-us58wwmp 3300 8 the the DT cord-015306-us58wwmp 3300 9 target target NN cord-015306-us58wwmp 3300 10 level level NN cord-015306-us58wwmp 3300 11 by by IN cord-015306-us58wwmp 3300 12 different different JJ cord-015306-us58wwmp 3300 13 CKD CKD NNP cord-015306-us58wwmp 3300 14 stages stage NNS cord-015306-us58wwmp 3300 15 in in IN cord-015306-us58wwmp 3300 16 52 52 CD cord-015306-us58wwmp 3300 17 % % NN cord-015306-us58wwmp 3300 18 of of IN cord-015306-us58wwmp 3300 19 the the DT cord-015306-us58wwmp 3300 20 group group NN cord-015306-us58wwmp 3300 21 1 1 CD cord-015306-us58wwmp 3300 22 patients patient NNS cord-015306-us58wwmp 3300 23 , , , cord-015306-us58wwmp 3300 24 in in IN cord-015306-us58wwmp 3300 25 58 58 CD cord-015306-us58wwmp 3300 26 % % NN cord-015306-us58wwmp 3300 27 of of IN cord-015306-us58wwmp 3300 28 the the DT cord-015306-us58wwmp 3300 29 group group NN cord-015306-us58wwmp 3300 30 2 2 CD cord-015306-us58wwmp 3300 31 and and CC cord-015306-us58wwmp 3300 32 in in IN cord-015306-us58wwmp 3300 33 52 52 CD cord-015306-us58wwmp 3300 34 % % NN cord-015306-us58wwmp 3300 35 of of IN cord-015306-us58wwmp 3300 36 the the DT cord-015306-us58wwmp 3300 37 group group NN cord-015306-us58wwmp 3300 38 3 3 CD cord-015306-us58wwmp 3300 39 and and CC cord-015306-us58wwmp 3300 40 showed show VBD cord-015306-us58wwmp 3300 41 an an DT cord-015306-us58wwmp 3300 42 inverse inverse JJ cord-015306-us58wwmp 3300 43 correlation correlation NN cord-015306-us58wwmp 3300 44 with with IN cord-015306-us58wwmp 3300 45 25OHD 25ohd CD cord-015306-us58wwmp 3300 46 levels level NNS cord-015306-us58wwmp 3300 47 ( ( -LRB- cord-015306-us58wwmp 3300 48 p<0.05 p<0.05 CD cord-015306-us58wwmp 3300 49 , , , cord-015306-us58wwmp 3300 50 r=−0.25 r=−0.25 RB cord-015306-us58wwmp 3300 51 ) ) -RRB- cord-015306-us58wwmp 3300 52 . . . cord-015306-us58wwmp 3301 1 There there EX cord-015306-us58wwmp 3301 2 was be VBD cord-015306-us58wwmp 3301 3 inverse inverse JJ cord-015306-us58wwmp 3301 4 correlation correlation NN cord-015306-us58wwmp 3301 5 with with IN cord-015306-us58wwmp 3301 6 age age NN cord-015306-us58wwmp 3301 7 in in IN cord-015306-us58wwmp 3301 8 the the DT cord-015306-us58wwmp 3301 9 complete complete JJ cord-015306-us58wwmp 3301 10 cohort cohort NN cord-015306-us58wwmp 3301 11 of of IN cord-015306-us58wwmp 3301 12 patients patient NNS cord-015306-us58wwmp 3301 13 ( ( -LRB- cord-015306-us58wwmp 3301 14 p=0.0005 p=0.0005 NNS cord-015306-us58wwmp 3301 15 , , . cord-015306-us58wwmp 3302 1 r r LS cord-015306-us58wwmp 3302 2 = = SYM cord-015306-us58wwmp 3302 3 −0.33 −0.33 NNP cord-015306-us58wwmp 3302 4 ) ) -RRB- cord-015306-us58wwmp 3302 5 Height Height NNP cord-015306-us58wwmp 3302 6 standard standard JJ cord-015306-us58wwmp 3302 7 deviation deviation NN cord-015306-us58wwmp 3302 8 score score NN cord-015306-us58wwmp 3302 9 ( ( -LRB- cord-015306-us58wwmp 3302 10 SDS SDS NNP cord-015306-us58wwmp 3302 11 ) ) -RRB- cord-015306-us58wwmp 3302 12 was be VBD cord-015306-us58wwmp 3302 13 associated associate VBN cord-015306-us58wwmp 3302 14 with with IN cord-015306-us58wwmp 3302 15 25OHD 25ohd CD cord-015306-us58wwmp 3302 16 only only RB cord-015306-us58wwmp 3302 17 in in IN cord-015306-us58wwmp 3302 18 group group NN cord-015306-us58wwmp 3302 19 2 2 CD cord-015306-us58wwmp 3302 20 ( ( -LRB- cord-015306-us58wwmp 3302 21 p=0.025 p=0.025 NNP cord-015306-us58wwmp 3302 22 , , , cord-015306-us58wwmp 3302 23 r=0.45 r=0.45 NNP cord-015306-us58wwmp 3302 24 ) ) -RRB- cord-015306-us58wwmp 3302 25 . . . cord-015306-us58wwmp 3303 1 There there EX cord-015306-us58wwmp 3303 2 was be VBD cord-015306-us58wwmp 3303 3 direct direct JJ cord-015306-us58wwmp 3303 4 correlation correlation NN cord-015306-us58wwmp 3303 5 between between IN cord-015306-us58wwmp 3303 6 25OHD 25ohd CD cord-015306-us58wwmp 3303 7 levels level NNS cord-015306-us58wwmp 3303 8 and and CC cord-015306-us58wwmp 3303 9 GFR GFR NNP cord-015306-us58wwmp 3303 10 in in IN cord-015306-us58wwmp 3303 11 group group NN cord-015306-us58wwmp 3303 12 1 1 CD cord-015306-us58wwmp 3303 13 and and CC cord-015306-us58wwmp 3303 14 2 2 CD cord-015306-us58wwmp 3303 15 . . . cord-015306-us58wwmp 3304 1 Conclusion conclusion NN cord-015306-us58wwmp 3304 2 : : : cord-015306-us58wwmp 3305 1 Our -PRON- PRP$ cord-015306-us58wwmp 3305 2 data datum NNS cord-015306-us58wwmp 3305 3 suggest suggest VBP cord-015306-us58wwmp 3305 4 that that IN cord-015306-us58wwmp 3305 5 25OHD 25ohd CD cord-015306-us58wwmp 3305 6 deficiency deficiency NN cord-015306-us58wwmp 3305 7 is be VBZ cord-015306-us58wwmp 3305 8 common common JJ cord-015306-us58wwmp 3305 9 in in IN cord-015306-us58wwmp 3305 10 pediatric pediatric JJ cord-015306-us58wwmp 3305 11 renal renal JJ cord-015306-us58wwmp 3305 12 transplant transplant NN cord-015306-us58wwmp 3305 13 and and CC cord-015306-us58wwmp 3305 14 CKD CKD NNP cord-015306-us58wwmp 3305 15 children child NNS cord-015306-us58wwmp 3305 16 of of IN cord-015306-us58wwmp 3305 17 any any DT cord-015306-us58wwmp 3305 18 stage stage NN cord-015306-us58wwmp 3305 19 even even RB cord-015306-us58wwmp 3305 20 in in IN cord-015306-us58wwmp 3305 21 an an DT cord-015306-us58wwmp 3305 22 area area NN cord-015306-us58wwmp 3305 23 with with IN cord-015306-us58wwmp 3305 24 year year NN cord-015306-us58wwmp 3305 25 - - HYPH cord-015306-us58wwmp 3305 26 long long JJ cord-015306-us58wwmp 3305 27 sunshine sunshine NN cord-015306-us58wwmp 3305 28 , , , cord-015306-us58wwmp 3305 29 especially especially RB cord-015306-us58wwmp 3305 30 in in IN cord-015306-us58wwmp 3305 31 adolescents adolescent NNS cord-015306-us58wwmp 3305 32 . . . cord-015306-us58wwmp 3306 1 Hyperparathyroidism Hyperparathyroidism NNP cord-015306-us58wwmp 3306 2 was be VBD cord-015306-us58wwmp 3306 3 also also RB cord-015306-us58wwmp 3306 4 frequent frequent JJ cord-015306-us58wwmp 3306 5 in in IN cord-015306-us58wwmp 3306 6 all all DT cord-015306-us58wwmp 3306 7 groups group NNS cord-015306-us58wwmp 3306 8 . . . cord-015306-us58wwmp 3307 1 It -PRON- PRP cord-015306-us58wwmp 3307 2 would would MD cord-015306-us58wwmp 3307 3 be be VB cord-015306-us58wwmp 3307 4 advisable advisable JJ cord-015306-us58wwmp 3307 5 to to TO cord-015306-us58wwmp 3307 6 monitor monitor VB cord-015306-us58wwmp 3307 7 vitamin vitamin NN cord-015306-us58wwmp 3307 8 D d NN cord-015306-us58wwmp 3307 9 status status NN cord-015306-us58wwmp 3307 10 in in IN cord-015306-us58wwmp 3307 11 these these DT cord-015306-us58wwmp 3307 12 patients patient NNS cord-015306-us58wwmp 3307 13 . . . cord-015306-us58wwmp 3308 1 3 3 LS cord-015306-us58wwmp 3308 2 ) ) -RRB- cord-015306-us58wwmp 3308 3 years year NNS cord-015306-us58wwmp 3308 4 , , , cord-015306-us58wwmp 3308 5 28 28 CD cord-015306-us58wwmp 3308 6 with with IN cord-015306-us58wwmp 3308 7 CKD CKD NNP cord-015306-us58wwmp 3308 8 5 5 CD cord-015306-us58wwmp 3308 9 ( ( -LRB- cord-015306-us58wwmp 3308 10 2 2 CD cord-015306-us58wwmp 3308 11 on on IN cord-015306-us58wwmp 3308 12 HD HD NNP cord-015306-us58wwmp 3308 13 , , , cord-015306-us58wwmp 3308 14 9 9 CD cord-015306-us58wwmp 3308 15 on on IN cord-015306-us58wwmp 3308 16 PD PD NNP cord-015306-us58wwmp 3308 17 and and CC cord-015306-us58wwmp 3308 18 17 17 CD cord-015306-us58wwmp 3308 19 Tx Tx NNP cord-015306-us58wwmp 3308 20 ) ) -RRB- cord-015306-us58wwmp 3309 1 mean mean VB cord-015306-us58wwmp 3309 2 age age NN cord-015306-us58wwmp 3309 3 13 13 CD cord-015306-us58wwmp 3309 4 ( ( -LRB- cord-015306-us58wwmp 3309 5 5.4 5.4 CD cord-015306-us58wwmp 3309 6 - - SYM cord-015306-us58wwmp 3309 7 17.5 17.5 CD cord-015306-us58wwmp 3309 8 ) ) -RRB- cord-015306-us58wwmp 3309 9 and and CC cord-015306-us58wwmp 3309 10 113 113 CD cord-015306-us58wwmp 3309 11 healthy healthy JJ cord-015306-us58wwmp 3309 12 children child NNS cord-015306-us58wwmp 3309 13 , , . cord-015306-us58wwmp 3310 1 mean mean VB cord-015306-us58wwmp 3310 2 age age NN cord-015306-us58wwmp 3310 3 11.5 11.5 CD cord-015306-us58wwmp 3311 1 ( ( -LRB- cord-015306-us58wwmp 3311 2 5 5 CD cord-015306-us58wwmp 3311 3 - - SYM cord-015306-us58wwmp 3311 4 17.9 17.9 CD cord-015306-us58wwmp 3311 5 Objective objective NN cord-015306-us58wwmp 3311 6 : : : cord-015306-us58wwmp 3311 7 The the DT cord-015306-us58wwmp 3311 8 aim aim NN cord-015306-us58wwmp 3311 9 of of IN cord-015306-us58wwmp 3311 10 our -PRON- PRP$ cord-015306-us58wwmp 3311 11 study study NN cord-015306-us58wwmp 3311 12 was be VBD cord-015306-us58wwmp 3311 13 to to TO cord-015306-us58wwmp 3311 14 analyze analyze VB cord-015306-us58wwmp 3311 15 twelve twelve CD cord-015306-us58wwmp 3311 16 single single JJ cord-015306-us58wwmp 3311 17 nucleotide nucleotide JJ cord-015306-us58wwmp 3311 18 polymorphisms polymorphism NNS cord-015306-us58wwmp 3311 19 ( ( -LRB- cord-015306-us58wwmp 3311 20 SNP SNP NNP cord-015306-us58wwmp 3311 21 ) ) -RRB- cord-015306-us58wwmp 3311 22 of of IN cord-015306-us58wwmp 3311 23 gene gene NN cord-015306-us58wwmp 3311 24 LRP5 LRP5 NNP cord-015306-us58wwmp 3311 25 potentially potentially RB cord-015306-us58wwmp 3311 26 associated associate VBN cord-015306-us58wwmp 3311 27 with with IN cord-015306-us58wwmp 3311 28 osteoporosis osteoporosis NN cord-015306-us58wwmp 3311 29 risk risk NN cord-015306-us58wwmp 3311 30 in in IN cord-015306-us58wwmp 3311 31 children child NNS cord-015306-us58wwmp 3311 32 with with IN cord-015306-us58wwmp 3311 33 routine routine JJ cord-015306-us58wwmp 3311 34 steroidotherapy steroidotherapy NN cord-015306-us58wwmp 3311 35 in in IN cord-015306-us58wwmp 3311 36 the the DT cord-015306-us58wwmp 3311 37 course course NN cord-015306-us58wwmp 3311 38 of of IN cord-015306-us58wwmp 3311 39 the the DT cord-015306-us58wwmp 3311 40 idiopathic idiopathic JJ cord-015306-us58wwmp 3311 41 nephrotic nephrotic JJ cord-015306-us58wwmp 3311 42 syndrome syndrome NN cord-015306-us58wwmp 3311 43 . . . cord-015306-us58wwmp 3312 1 Methods method NNS cord-015306-us58wwmp 3312 2 and and CC cord-015306-us58wwmp 3312 3 Results result NNS cord-015306-us58wwmp 3312 4 : : : cord-015306-us58wwmp 3312 5 Glucocorticosteroids glucocorticosteroid NNS cord-015306-us58wwmp 3312 6 are be VBP cord-015306-us58wwmp 3312 7 important important JJ cord-015306-us58wwmp 3312 8 risk risk NN cord-015306-us58wwmp 3312 9 factors factor NNS cord-015306-us58wwmp 3312 10 for for IN cord-015306-us58wwmp 3312 11 drug drug NN cord-015306-us58wwmp 3312 12 induced induce VBN cord-015306-us58wwmp 3312 13 osteoporosis osteoporosis NN cord-015306-us58wwmp 3312 14 . . . cord-015306-us58wwmp 3313 1 Decrease decrease VB cord-015306-us58wwmp 3313 2 in in IN cord-015306-us58wwmp 3313 3 bone bone NN cord-015306-us58wwmp 3313 4 mineral mineral NN cord-015306-us58wwmp 3313 5 density density NN cord-015306-us58wwmp 3313 6 ( ( -LRB- cord-015306-us58wwmp 3313 7 BMD BMD NNP cord-015306-us58wwmp 3313 8 ) ) -RRB- cord-015306-us58wwmp 3313 9 and and CC cord-015306-us58wwmp 3313 10 increased increase VBN cord-015306-us58wwmp 3313 11 risk risk NN cord-015306-us58wwmp 3313 12 for for IN cord-015306-us58wwmp 3313 13 pathological pathological JJ cord-015306-us58wwmp 3313 14 fractures fracture NNS cord-015306-us58wwmp 3313 15 are be VBP cord-015306-us58wwmp 3313 16 caused cause VBN cord-015306-us58wwmp 3313 17 by by IN cord-015306-us58wwmp 3313 18 direct direct JJ cord-015306-us58wwmp 3313 19 division division NN cord-015306-us58wwmp 3313 20 of of IN cord-015306-us58wwmp 3313 21 steroids steroid NNS cord-015306-us58wwmp 3313 22 at at IN cord-015306-us58wwmp 3313 23 the the DT cord-015306-us58wwmp 3313 24 cellular cellular JJ cord-015306-us58wwmp 3313 25 level level NN cord-015306-us58wwmp 3313 26 by by IN cord-015306-us58wwmp 3313 27 inhibiting inhibit VBG cord-015306-us58wwmp 3313 28 the the DT cord-015306-us58wwmp 3313 29 replication replication NN cord-015306-us58wwmp 3313 30 of of IN cord-015306-us58wwmp 3313 31 osteoblasts osteoblast NNS cord-015306-us58wwmp 3313 32 and and CC cord-015306-us58wwmp 3313 33 stimulation stimulation NN cord-015306-us58wwmp 3313 34 of of IN cord-015306-us58wwmp 3313 35 its -PRON- PRP$ cord-015306-us58wwmp 3313 36 apoptosis apoptosis NN cord-015306-us58wwmp 3313 37 . . . cord-015306-us58wwmp 3314 1 Also also RB cord-015306-us58wwmp 3314 2 proven prove VBN cord-015306-us58wwmp 3314 3 its -PRON- PRP$ cord-015306-us58wwmp 3314 4 effects effect NNS cord-015306-us58wwmp 3314 5 on on IN cord-015306-us58wwmp 3314 6 the the DT cord-015306-us58wwmp 3314 7 inhibition inhibition NN cord-015306-us58wwmp 3314 8 of of IN cord-015306-us58wwmp 3314 9 type type NN cord-015306-us58wwmp 3314 10 I -PRON- PRP cord-015306-us58wwmp 3314 11 collagen collagen NN cord-015306-us58wwmp 3314 12 synthesis synthesis NN cord-015306-us58wwmp 3314 13 . . . cord-015306-us58wwmp 3315 1 LRP5 LRP5 NNP cord-015306-us58wwmp 3315 2 is be VBZ cord-015306-us58wwmp 3315 3 one one CD cord-015306-us58wwmp 3315 4 of of IN cord-015306-us58wwmp 3315 5 the the DT cord-015306-us58wwmp 3315 6 Wnt Wnt NNP cord-015306-us58wwmp 3315 7 signaling signal VBG cord-015306-us58wwmp 3315 8 pathway pathway NN cord-015306-us58wwmp 3315 9 proteins protein NNS cord-015306-us58wwmp 3315 10 coreceptors coreceptor NNS cord-015306-us58wwmp 3315 11 involved involve VBN cord-015306-us58wwmp 3315 12 through through IN cord-015306-us58wwmp 3315 13 the the DT cord-015306-us58wwmp 3315 14 RANK rank NN cord-015306-us58wwmp 3315 15 - - HYPH cord-015306-us58wwmp 3315 16 RANKL RANKL NNP cord-015306-us58wwmp 3315 17 system system NN cord-015306-us58wwmp 3315 18 in in IN cord-015306-us58wwmp 3315 19 regulation regulation NN cord-015306-us58wwmp 3315 20 of of IN cord-015306-us58wwmp 3315 21 the the DT cord-015306-us58wwmp 3315 22 osteoblasts osteoblast NNS cord-015306-us58wwmp 3315 23 function function NN cord-015306-us58wwmp 3315 24 . . . cord-015306-us58wwmp 3316 1 LRP5 LRP5 NNP cord-015306-us58wwmp 3316 2 is be VBZ cord-015306-us58wwmp 3316 3 included include VBN cord-015306-us58wwmp 3316 4 to to IN cord-015306-us58wwmp 3316 5 the the DT cord-015306-us58wwmp 3316 6 osteoporosis osteoporosis NN cord-015306-us58wwmp 3316 7 phenotype phenotype NN cord-015306-us58wwmp 3316 8 genes gene NNS cord-015306-us58wwmp 3316 9 group group NN cord-015306-us58wwmp 3316 10 and and CC cord-015306-us58wwmp 3316 11 its -PRON- PRP$ cord-015306-us58wwmp 3316 12 selected select VBN cord-015306-us58wwmp 3316 13 single single JJ cord-015306-us58wwmp 3316 14 nucleotide nucleotide JJ cord-015306-us58wwmp 3316 15 polymorphisms polymorphism NNS cord-015306-us58wwmp 3316 16 can can MD cord-015306-us58wwmp 3316 17 be be VB cord-015306-us58wwmp 3316 18 responsible responsible JJ cord-015306-us58wwmp 3316 19 for for IN cord-015306-us58wwmp 3316 20 BMD bmd NN cord-015306-us58wwmp 3316 21 decrease decrease NN cord-015306-us58wwmp 3316 22 in in IN cord-015306-us58wwmp 3316 23 patients patient NNS cord-015306-us58wwmp 3316 24 with with IN cord-015306-us58wwmp 3316 25 glucocorticoid glucocorticoid NN cord-015306-us58wwmp 3316 26 therapy therapy NN cord-015306-us58wwmp 3316 27 . . . cord-015306-us58wwmp 3317 1 The the DT cord-015306-us58wwmp 3317 2 study study NN cord-015306-us58wwmp 3317 3 group group NN cord-015306-us58wwmp 3317 4 was be VBD cord-015306-us58wwmp 3317 5 composed compose VBN cord-015306-us58wwmp 3317 6 of of IN cord-015306-us58wwmp 3317 7 38 38 CD cord-015306-us58wwmp 3317 8 children child NNS cord-015306-us58wwmp 3317 9 with with IN cord-015306-us58wwmp 3317 10 idiopathic idiopathic JJ cord-015306-us58wwmp 3317 11 nephrotic nephrotic JJ cord-015306-us58wwmp 3317 12 syndrome syndrome NN cord-015306-us58wwmp 3317 13 , , , cord-015306-us58wwmp 3317 14 21 21 CD cord-015306-us58wwmp 3317 15 boys boy NNS cord-015306-us58wwmp 3317 16 and and CC cord-015306-us58wwmp 3317 17 17 17 CD cord-015306-us58wwmp 3317 18 girls girl NNS cord-015306-us58wwmp 3317 19 beetwen beetwen VBP cord-015306-us58wwmp 3317 20 the the DT cord-015306-us58wwmp 3317 21 age age NN cord-015306-us58wwmp 3317 22 of of IN cord-015306-us58wwmp 3317 23 five five CD cord-015306-us58wwmp 3317 24 to to TO cord-015306-us58wwmp 3317 25 twelve twelve CD cord-015306-us58wwmp 3317 26 years year NNS cord-015306-us58wwmp 3317 27 old old JJ cord-015306-us58wwmp 3317 28 , , , cord-015306-us58wwmp 3317 29 14 14 CD cord-015306-us58wwmp 3317 30 with with IN cord-015306-us58wwmp 3317 31 osteoporosis osteoporosis NN cord-015306-us58wwmp 3317 32 and and CC cord-015306-us58wwmp 3317 33 24 24 CD cord-015306-us58wwmp 3317 34 with with IN cord-015306-us58wwmp 3317 35 normal normal JJ cord-015306-us58wwmp 3317 36 bone bone NN cord-015306-us58wwmp 3317 37 mass mass NN cord-015306-us58wwmp 3317 38 density density NN cord-015306-us58wwmp 3317 39 . . . cord-015306-us58wwmp 3318 1 Study study NN cord-015306-us58wwmp 3318 2 also also RB cord-015306-us58wwmp 3318 3 included include VBD cord-015306-us58wwmp 3318 4 the the DT cord-015306-us58wwmp 3318 5 control control NN cord-015306-us58wwmp 3318 6 group group NN cord-015306-us58wwmp 3318 7 consists consist VBZ cord-015306-us58wwmp 3318 8 of of IN cord-015306-us58wwmp 3318 9 102 102 CD cord-015306-us58wwmp 3318 10 healthy healthy JJ cord-015306-us58wwmp 3318 11 individuals individual NNS cord-015306-us58wwmp 3318 12 at at IN cord-015306-us58wwmp 3318 13 the the DT cord-015306-us58wwmp 3318 14 same same JJ cord-015306-us58wwmp 3318 15 age age NN cord-015306-us58wwmp 3318 16 not not RB cord-015306-us58wwmp 3318 17 treated treat VBN cord-015306-us58wwmp 3318 18 with with IN cord-015306-us58wwmp 3318 19 glucocorticoids glucocorticoid NNS cord-015306-us58wwmp 3318 20 . . . cord-015306-us58wwmp 3319 1 The the DT cord-015306-us58wwmp 3319 2 analysis analysis NN cord-015306-us58wwmp 3319 3 was be VBD cord-015306-us58wwmp 3319 4 carried carry VBN cord-015306-us58wwmp 3319 5 out out RP cord-015306-us58wwmp 3319 6 with with IN cord-015306-us58wwmp 3319 7 polimerase polimerase NNP cord-015306-us58wwmp 3319 8 chain chain NN cord-015306-us58wwmp 3319 9 reaction reaction NN cord-015306-us58wwmp 3319 10 ( ( -LRB- cord-015306-us58wwmp 3319 11 PCR PCR NNP cord-015306-us58wwmp 3319 12 ) ) -RRB- cord-015306-us58wwmp 3319 13 and and CC cord-015306-us58wwmp 3320 1 TaqMan TaqMan NNP cord-015306-us58wwmp 3320 2 molecular molecular JJ cord-015306-us58wwmp 3320 3 probe probe NN cord-015306-us58wwmp 3320 4 designed design VBN cord-015306-us58wwmp 3320 5 for for IN cord-015306-us58wwmp 3320 6 12 12 CD cord-015306-us58wwmp 3320 7 single single JJ cord-015306-us58wwmp 3320 8 nucleotide nucleotide JJ cord-015306-us58wwmp 3320 9 polymorphisms polymorphism NNS cord-015306-us58wwmp 3320 10 ( ( -LRB- cord-015306-us58wwmp 3320 11 SNPs SNPs NNP cord-015306-us58wwmp 3320 12 ) ) -RRB- cord-015306-us58wwmp 3320 13 nearby nearby RB cord-015306-us58wwmp 3320 14 investigated investigate VBN cord-015306-us58wwmp 3320 15 mutations mutation NNS cord-015306-us58wwmp 3320 16 in in IN cord-015306-us58wwmp 3320 17 LRP5 LRP5 NNP cord-015306-us58wwmp 3320 18 gene gene NN cord-015306-us58wwmp 3320 19 that that WDT cord-015306-us58wwmp 3320 20 can can MD cord-015306-us58wwmp 3320 21 be be VB cord-015306-us58wwmp 3320 22 connected connect VBN cord-015306-us58wwmp 3320 23 with with IN cord-015306-us58wwmp 3320 24 osteoporosis osteoporosis NN cord-015306-us58wwmp 3320 25 fenotype fenotype NN cord-015306-us58wwmp 3320 26 . . . cord-015306-us58wwmp 3321 1 Odds odd NNS cord-015306-us58wwmp 3321 2 ratio ratio NN cord-015306-us58wwmp 3321 3 value value NN cord-015306-us58wwmp 3321 4 ( ( -LRB- cord-015306-us58wwmp 3321 5 OR or NN cord-015306-us58wwmp 3321 6 ) ) -RRB- cord-015306-us58wwmp 3321 7 was be VBD cord-015306-us58wwmp 3321 8 based base VBN cord-015306-us58wwmp 3321 9 on on IN cord-015306-us58wwmp 3321 10 frequencies frequency NNS cord-015306-us58wwmp 3321 11 of of IN cord-015306-us58wwmp 3321 12 single single JJ cord-015306-us58wwmp 3321 13 nucleotide nucleotide JJ cord-015306-us58wwmp 3321 14 polymorphisms polymorphism NNS cord-015306-us58wwmp 3321 15 in in IN cord-015306-us58wwmp 3321 16 LRP5 LRP5 NNP cord-015306-us58wwmp 3321 17 gene gene NN cord-015306-us58wwmp 3321 18 and and CC cord-015306-us58wwmp 3321 19 its -PRON- PRP$ cord-015306-us58wwmp 3321 20 haplotype haplotype NN cord-015306-us58wwmp 3321 21 analysis analysis NN cord-015306-us58wwmp 3321 22 . . . cord-015306-us58wwmp 3322 1 The the DT cord-015306-us58wwmp 3322 2 results result NNS cord-015306-us58wwmp 3322 3 showed show VBD cord-015306-us58wwmp 3322 4 significant significant JJ cord-015306-us58wwmp 3322 5 differences difference NNS cord-015306-us58wwmp 3322 6 in in IN cord-015306-us58wwmp 3322 7 OR or CC cord-015306-us58wwmp 3322 8 value value NN cord-015306-us58wwmp 3322 9 among among IN cord-015306-us58wwmp 3322 10 the the DT cord-015306-us58wwmp 3322 11 three three CD cord-015306-us58wwmp 3322 12 groups group NNS cord-015306-us58wwmp 3322 13 . . . cord-015306-us58wwmp 3323 1 It -PRON- PRP cord-015306-us58wwmp 3323 2 was be VBD cord-015306-us58wwmp 3323 3 also also RB cord-015306-us58wwmp 3323 4 found find VBN cord-015306-us58wwmp 3323 5 the the DT cord-015306-us58wwmp 3323 6 differences difference NNS cord-015306-us58wwmp 3323 7 in in IN cord-015306-us58wwmp 3323 8 the the DT cord-015306-us58wwmp 3323 9 LRP5 LRP5 NNP cord-015306-us58wwmp 3323 10 gene gene NN cord-015306-us58wwmp 3323 11 structure structure NN cord-015306-us58wwmp 3323 12 . . . cord-015306-us58wwmp 3324 1 Based base VBN cord-015306-us58wwmp 3324 2 on on IN cord-015306-us58wwmp 3324 3 Gabriel Gabriel NNP cord-015306-us58wwmp 3324 4 algorytm algorytm NNP cord-015306-us58wwmp 3324 5 single single JJ cord-015306-us58wwmp 3324 6 nucleotide nucleotide JJ cord-015306-us58wwmp 3324 7 polymorphisms polymorphism NNS cord-015306-us58wwmp 3324 8 pairs pair NNS cord-015306-us58wwmp 3324 9 analysis analysis NN cord-015306-us58wwmp 3324 10 in in IN cord-015306-us58wwmp 3324 11 children child NNS cord-015306-us58wwmp 3324 12 with with IN cord-015306-us58wwmp 3324 13 osteoporosis osteoporosis NN cord-015306-us58wwmp 3324 14 and and CC cord-015306-us58wwmp 3324 15 nephrotic nephrotic JJ cord-015306-us58wwmp 3324 16 syndrome syndrome NN cord-015306-us58wwmp 3325 1 we -PRON- PRP cord-015306-us58wwmp 3325 2 proved prove VBD cord-015306-us58wwmp 3325 3 the the DT cord-015306-us58wwmp 3325 4 correlation correlation NN cord-015306-us58wwmp 3325 5 between between IN cord-015306-us58wwmp 3325 6 selected select VBN cord-015306-us58wwmp 3325 7 SNPs SNPs NNP cord-015306-us58wwmp 3325 8 pairs pair NNS cord-015306-us58wwmp 3325 9 presence presence NN cord-015306-us58wwmp 3325 10 and and CC cord-015306-us58wwmp 3325 11 decretion decretion NN cord-015306-us58wwmp 3325 12 of of IN cord-015306-us58wwmp 3325 13 bone bone NN cord-015306-us58wwmp 3325 14 mineral mineral NN cord-015306-us58wwmp 3325 15 density density NN cord-015306-us58wwmp 3325 16 in in IN cord-015306-us58wwmp 3325 17 studied study VBN cord-015306-us58wwmp 3325 18 group group NN cord-015306-us58wwmp 3325 19 . . . cord-015306-us58wwmp 3326 1 Objective objective NN cord-015306-us58wwmp 3326 2 : : : cord-015306-us58wwmp 3327 1 Growth growth NN cord-015306-us58wwmp 3327 2 hormone hormone NN cord-015306-us58wwmp 3327 3 ( ( -LRB- cord-015306-us58wwmp 3327 4 GH GH NNP cord-015306-us58wwmp 3327 5 ) ) -RRB- cord-015306-us58wwmp 3327 6 and and CC cord-015306-us58wwmp 3327 7 insulin insulin NN cord-015306-us58wwmp 3327 8 - - HYPH cord-015306-us58wwmp 3327 9 like like JJ cord-015306-us58wwmp 3327 10 growth growth NN cord-015306-us58wwmp 3327 11 factors factor NNS cord-015306-us58wwmp 3327 12 are be VBP cord-015306-us58wwmp 3327 13 essential essential JJ cord-015306-us58wwmp 3327 14 for for IN cord-015306-us58wwmp 3327 15 normal normal JJ cord-015306-us58wwmp 3327 16 growth growth NN cord-015306-us58wwmp 3327 17 and and CC cord-015306-us58wwmp 3327 18 development development NN cord-015306-us58wwmp 3327 19 . . . cord-015306-us58wwmp 3328 1 Chronic chronic JJ cord-015306-us58wwmp 3328 2 renal renal JJ cord-015306-us58wwmp 3328 3 failure failure NN cord-015306-us58wwmp 3328 4 ( ( -LRB- cord-015306-us58wwmp 3328 5 CRF CRF NNP cord-015306-us58wwmp 3328 6 ) ) -RRB- cord-015306-us58wwmp 3328 7 results result VBZ cord-015306-us58wwmp 3328 8 in in IN cord-015306-us58wwmp 3328 9 major major JJ cord-015306-us58wwmp 3328 10 changes change NNS cord-015306-us58wwmp 3328 11 in in IN cord-015306-us58wwmp 3328 12 the the DT cord-015306-us58wwmp 3328 13 circulating circulate VBG cord-015306-us58wwmp 3328 14 growth growth NN cord-015306-us58wwmp 3328 15 hormone hormone NN cord-015306-us58wwmp 3328 16 /insulin /insulin . cord-015306-us58wwmp 3328 17 - - HYPH cord-015306-us58wwmp 3328 18 like like JJ cord-015306-us58wwmp 3328 19 growth growth NN cord-015306-us58wwmp 3328 20 factor factor NN cord-015306-us58wwmp 3328 21 ( ( -LRB- cord-015306-us58wwmp 3328 22 IGF IGF NNP cord-015306-us58wwmp 3328 23 ) ) -RRB- cord-015306-us58wwmp 3328 24 system system NN cord-015306-us58wwmp 3328 25 . . . cord-015306-us58wwmp 3329 1 Our -PRON- PRP$ cord-015306-us58wwmp 3329 2 aim aim NN cord-015306-us58wwmp 3329 3 isto isto NNP cord-015306-us58wwmp 3329 4 study study NN cord-015306-us58wwmp 3329 5 : : : cord-015306-us58wwmp 3329 6 To to TO cord-015306-us58wwmp 3329 7 assess assess VB cord-015306-us58wwmp 3329 8 clinical clinical JJ cord-015306-us58wwmp 3329 9 and and CC cord-015306-us58wwmp 3329 10 laboratory laboratory NN cord-015306-us58wwmp 3329 11 parameters parameter NNS cord-015306-us58wwmp 3329 12 of of IN cord-015306-us58wwmp 3329 13 growth growth NN cord-015306-us58wwmp 3329 14 and and CC cord-015306-us58wwmp 3329 15 osteodystrophy osteodystrophy NN cord-015306-us58wwmp 3329 16 including include VBG cord-015306-us58wwmp 3329 17 IGF1 IGF1 NNP cord-015306-us58wwmp 3329 18 and and CC cord-015306-us58wwmp 3329 19 IGFBP2 igfbp2 NN cord-015306-us58wwmp 3329 20 as as IN cord-015306-us58wwmp 3329 21 part part NN cord-015306-us58wwmp 3329 22 of of IN cord-015306-us58wwmp 3329 23 the the DT cord-015306-us58wwmp 3329 24 somatotropic somatotropic JJ cord-015306-us58wwmp 3329 25 hormone hormone NN cord-015306-us58wwmp 3329 26 axis axis NN cord-015306-us58wwmp 3329 27 in in IN cord-015306-us58wwmp 3329 28 Egyptian egyptian JJ cord-015306-us58wwmp 3329 29 children child NNS cord-015306-us58wwmp 3329 30 suffering suffer VBG cord-015306-us58wwmp 3329 31 from from IN cord-015306-us58wwmp 3329 32 CRF CRF NNP cord-015306-us58wwmp 3329 33 on on IN cord-015306-us58wwmp 3329 34 conservative conservative JJ cord-015306-us58wwmp 3329 35 therapy therapy NN cord-015306-us58wwmp 3329 36 . . . cord-015306-us58wwmp 3330 1 Methods method NNS cord-015306-us58wwmp 3330 2 : : : cord-015306-us58wwmp 3330 3 62 62 CD cord-015306-us58wwmp 3330 4 Egyptian egyptian JJ cord-015306-us58wwmp 3330 5 children child NNS cord-015306-us58wwmp 3330 6 ( ( -LRB- cord-015306-us58wwmp 3330 7 47 47 CD cord-015306-us58wwmp 3330 8 boys boy NNS cord-015306-us58wwmp 3330 9 and and CC cord-015306-us58wwmp 3330 10 15 15 CD cord-015306-us58wwmp 3330 11 girls girl NNS cord-015306-us58wwmp 3330 12 ) ) -RRB- cord-015306-us58wwmp 3330 13 with with IN cord-015306-us58wwmp 3330 14 a a DT cord-015306-us58wwmp 3330 15 mean mean JJ cord-015306-us58wwmp 3330 16 age age NN cord-015306-us58wwmp 3330 17 of of IN cord-015306-us58wwmp 3330 18 9.7y 9.7y CD cord-015306-us58wwmp 3330 19 ( ( -LRB- cord-015306-us58wwmp 3330 20 0.47 0.47 CD cord-015306-us58wwmp 3330 21 to to IN cord-015306-us58wwmp 3330 22 21.12y 21.12y CD cord-015306-us58wwmp 3330 23 ) ) -RRB- cord-015306-us58wwmp 3330 24 suffering suffer VBG cord-015306-us58wwmp 3330 25 from from IN cord-015306-us58wwmp 3330 26 CRF CRF NNP cord-015306-us58wwmp 3330 27 on on IN cord-015306-us58wwmp 3330 28 conservative conservative JJ cord-015306-us58wwmp 3330 29 therapy therapy NN cord-015306-us58wwmp 3330 30 and and CC cord-015306-us58wwmp 3330 31 21 21 CD cord-015306-us58wwmp 3330 32 controls control NNS cord-015306-us58wwmp 3330 33 were be VBD cord-015306-us58wwmp 3330 34 included include VBN cord-015306-us58wwmp 3330 35 in in IN cord-015306-us58wwmp 3330 36 the the DT cord-015306-us58wwmp 3330 37 study study NN cord-015306-us58wwmp 3330 38 . . . cord-015306-us58wwmp 3331 1 Ht Ht NNP cord-015306-us58wwmp 3331 2 , , , cord-015306-us58wwmp 3331 3 wt wt NN cord-015306-us58wwmp 3331 4 and and CC cord-015306-us58wwmp 3331 5 TSF TSF NNP cord-015306-us58wwmp 3331 6 were be VBD cord-015306-us58wwmp 3331 7 measured measure VBN cord-015306-us58wwmp 3331 8 , , , cord-015306-us58wwmp 3331 9 pubertal pubertal JJ cord-015306-us58wwmp 3331 10 staging staging NN cord-015306-us58wwmp 3331 11 was be VBD cord-015306-us58wwmp 3331 12 assessed assess VBN cord-015306-us58wwmp 3331 13 and and CC cord-015306-us58wwmp 3331 14 followed follow VBN cord-015306-us58wwmp 3331 15 up up RP cord-015306-us58wwmp 3331 16 for for IN cord-015306-us58wwmp 3331 17 a a DT cord-015306-us58wwmp 3331 18 period period NN cord-015306-us58wwmp 3331 19 of of IN cord-015306-us58wwmp 3331 20 6 6 CD cord-015306-us58wwmp 3331 21 months month NNS cord-015306-us58wwmp 3331 22 . . . cord-015306-us58wwmp 3332 1 At at IN cord-015306-us58wwmp 3332 2 the the DT cord-015306-us58wwmp 3332 3 end end NN cord-015306-us58wwmp 3332 4 of of IN cord-015306-us58wwmp 3332 5 the the DT cord-015306-us58wwmp 3332 6 follow follow NN cord-015306-us58wwmp 3332 7 up up RP cord-015306-us58wwmp 3332 8 period period NN cord-015306-us58wwmp 3332 9 serum serum NN cord-015306-us58wwmp 3332 10 for for IN cord-015306-us58wwmp 3332 11 IGF1 IGF1 NNP cord-015306-us58wwmp 3332 12 and and CC cord-015306-us58wwmp 3332 13 IGFBP2 igfbp2 NN cord-015306-us58wwmp 3332 14 , , , cord-015306-us58wwmp 3332 15 renal renal JJ cord-015306-us58wwmp 3332 16 function function NN cord-015306-us58wwmp 3332 17 , , , cord-015306-us58wwmp 3332 18 electrolytes electrolyte NNS cord-015306-us58wwmp 3332 19 , , , cord-015306-us58wwmp 3332 20 Ca Ca NNP cord-015306-us58wwmp 3332 21 , , , cord-015306-us58wwmp 3332 22 P p NN cord-015306-us58wwmp 3332 23 , , , cord-015306-us58wwmp 3332 24 and and CC cord-015306-us58wwmp 3332 25 alkaline alkaline JJ cord-015306-us58wwmp 3332 26 phosphatase phosphatase NN cord-015306-us58wwmp 3332 27 and and CC cord-015306-us58wwmp 3332 28 acid acid NN cord-015306-us58wwmp 3332 29 base base NN cord-015306-us58wwmp 3332 30 balance balance NN cord-015306-us58wwmp 3332 31 were be VBD cord-015306-us58wwmp 3332 32 measured measure VBN cord-015306-us58wwmp 3332 33 and and CC cord-015306-us58wwmp 3332 34 an an DT cord-015306-us58wwmp 3332 35 X x NN cord-015306-us58wwmp 3332 36 - - NN cord-015306-us58wwmp 3332 37 ray ray NN cord-015306-us58wwmp 3332 38 of of IN cord-015306-us58wwmp 3332 39 the the DT cord-015306-us58wwmp 3332 40 left left JJ cord-015306-us58wwmp 3332 41 hand hand NN cord-015306-us58wwmp 3332 42 and and CC cord-015306-us58wwmp 3332 43 wrist wrist NN cord-015306-us58wwmp 3332 44 was be VBD cord-015306-us58wwmp 3332 45 done do VBN cord-015306-us58wwmp 3332 46 to to TO cord-015306-us58wwmp 3332 47 determine determine VB cord-015306-us58wwmp 3332 48 their -PRON- PRP$ cord-015306-us58wwmp 3332 49 bone bone NN cord-015306-us58wwmp 3332 50 age age NN cord-015306-us58wwmp 3332 51 by by IN cord-015306-us58wwmp 3332 52 Tanner Tanner NNP cord-015306-us58wwmp 3332 53 and and CC cord-015306-us58wwmp 3332 54 Whitehouse Whitehouse NNP cord-015306-us58wwmp 3332 55 . . . cord-015306-us58wwmp 3333 1 Results result NNS cord-015306-us58wwmp 3333 2 : : : cord-015306-us58wwmp 3334 1 Our -PRON- PRP$ cord-015306-us58wwmp 3334 2 study study NN cord-015306-us58wwmp 3334 3 shows show VBZ cord-015306-us58wwmp 3334 4 that that IN cord-015306-us58wwmp 3334 5 Children child NNS cord-015306-us58wwmp 3334 6 suffering suffer VBG cord-015306-us58wwmp 3334 7 from from IN cord-015306-us58wwmp 3334 8 CRF CRF NNP cord-015306-us58wwmp 3334 9 in in IN cord-015306-us58wwmp 3334 10 Egyptian egyptian JJ cord-015306-us58wwmp 3334 11 conservative conservative JJ cord-015306-us58wwmp 3334 12 therapy therapy NN cord-015306-us58wwmp 3334 13 have have VBP cord-015306-us58wwmp 3334 14 growth growth NN cord-015306-us58wwmp 3334 15 retardation retardation NN cord-015306-us58wwmp 3334 16 with with IN cord-015306-us58wwmp 3334 17 a a DT cord-015306-us58wwmp 3334 18 mean mean JJ cord-015306-us58wwmp 3334 19 ht ht NNP cord-015306-us58wwmp 3334 20 of of IN cord-015306-us58wwmp 3334 21 -3.7 -3.7 NNP cord-015306-us58wwmp 3334 22 SDS SDS NNP cord-015306-us58wwmp 3334 23 , , , cord-015306-us58wwmp 3334 24 a a DT cord-015306-us58wwmp 3334 25 mean mean NN cord-015306-us58wwmp 3334 26 wt wt NN cord-015306-us58wwmp 3334 27 of of IN cord-015306-us58wwmp 3334 28 -2.24 -2.24 CD cord-015306-us58wwmp 3334 29 SDS SDS NNP cord-015306-us58wwmp 3334 30 . . . cord-015306-us58wwmp 3335 1 TSF TSF NNP cord-015306-us58wwmp 3335 2 mean mean NN cord-015306-us58wwmp 3335 3 was be VBD cord-015306-us58wwmp 3335 4 -1.3 -1.3 CD cord-015306-us58wwmp 3335 5 SDS SDS NNP cord-015306-us58wwmp 3335 6 . . . cord-015306-us58wwmp 3336 1 On on IN cord-015306-us58wwmp 3336 2 the the DT cord-015306-us58wwmp 3336 3 average average NN cord-015306-us58wwmp 3336 4 the the DT cord-015306-us58wwmp 3336 5 patients patient NNS cord-015306-us58wwmp 3336 6 had have VBD cord-015306-us58wwmp 3336 7 a a DT cord-015306-us58wwmp 3336 8 delay delay NN cord-015306-us58wwmp 3336 9 of of IN cord-015306-us58wwmp 3336 10 2.95y 2.95y CD cord-015306-us58wwmp 3336 11 ( ( -LRB- cord-015306-us58wwmp 3336 12 + + CC cord-015306-us58wwmp 3337 1 /-2.0 /-2.0 NFP cord-015306-us58wwmp 3337 2 ) ) -RRB- cord-015306-us58wwmp 3338 1 in in IN cord-015306-us58wwmp 3338 2 their -PRON- PRP$ cord-015306-us58wwmp 3338 3 bone bone NN cord-015306-us58wwmp 3338 4 age age NN cord-015306-us58wwmp 3338 5 . . . cord-015306-us58wwmp 3339 1 Their -PRON- PRP$ cord-015306-us58wwmp 3339 2 height height NN cord-015306-us58wwmp 3339 3 was be VBD cord-015306-us58wwmp 3339 4 retarded retarded JJ cord-015306-us58wwmp 3339 5 more more JJR cord-015306-us58wwmp 3339 6 than than IN cord-015306-us58wwmp 3339 7 their -PRON- PRP$ cord-015306-us58wwmp 3339 8 bone bone NN cord-015306-us58wwmp 3339 9 age age NN cord-015306-us58wwmp 3339 10 with with IN cord-015306-us58wwmp 3339 11 a a DT cord-015306-us58wwmp 3339 12 height height NN cord-015306-us58wwmp 3339 13 age age NN cord-015306-us58wwmp 3339 14 / / SYM cord-015306-us58wwmp 3339 15 bone bone NN cord-015306-us58wwmp 3339 16 age age NN cord-015306-us58wwmp 3339 17 of of IN cord-015306-us58wwmp 3339 18 0.8 0.8 CD cord-015306-us58wwmp 3339 19 ( ( -LRB- cord-015306-us58wwmp 3339 20 + + CC cord-015306-us58wwmp 3339 21 /-0.18 /-0.18 . cord-015306-us58wwmp 3339 22 ) ) -RRB- cord-015306-us58wwmp 3339 23 . . . cord-015306-us58wwmp 3340 1 Alkaline alkaline JJ cord-015306-us58wwmp 3340 2 phosphatase phosphatase NN cord-015306-us58wwmp 3340 3 as as IN cord-015306-us58wwmp 3340 4 a a DT cord-015306-us58wwmp 3340 5 markers marker NNS cord-015306-us58wwmp 3340 6 of of IN cord-015306-us58wwmp 3340 7 renal renal JJ cord-015306-us58wwmp 3340 8 osteodystrophy osteodystrophy NN cord-015306-us58wwmp 3340 9 is be VBZ cord-015306-us58wwmp 3340 10 significantly significantly RB cord-015306-us58wwmp 3340 11 correlated correlate VBN cord-015306-us58wwmp 3340 12 to to IN cord-015306-us58wwmp 3340 13 the the DT cord-015306-us58wwmp 3340 14 height height NN cord-015306-us58wwmp 3340 15 , , , cord-015306-us58wwmp 3340 16 height height NN cord-015306-us58wwmp 3340 17 age age NN cord-015306-us58wwmp 3340 18 , , , cord-015306-us58wwmp 3340 19 bone bone NN cord-015306-us58wwmp 3340 20 age age NN cord-015306-us58wwmp 3340 21 and and CC cord-015306-us58wwmp 3340 22 to to IN cord-015306-us58wwmp 3340 23 the the DT cord-015306-us58wwmp 3340 24 pH. ph. NN cord-015306-us58wwmp 3341 1 The the DT cord-015306-us58wwmp 3341 2 mean mean JJ cord-015306-us58wwmp 3341 3 IGF1SDS IGF1SDS NNP cord-015306-us58wwmp 3341 4 ( ( -LRB- cord-015306-us58wwmp 3341 5 -0.6 -0.6 NN cord-015306-us58wwmp 3341 6 + + SYM cord-015306-us58wwmp 3341 7 /-1.8 /-1.8 . cord-015306-us58wwmp 3341 8 ) ) -RRB- cord-015306-us58wwmp 3341 9 did do VBD cord-015306-us58wwmp 3341 10 not not RB cord-015306-us58wwmp 3341 11 differ differ VB cord-015306-us58wwmp 3341 12 from from IN cord-015306-us58wwmp 3341 13 that that DT cord-015306-us58wwmp 3341 14 of of IN cord-015306-us58wwmp 3341 15 controls control NNS cord-015306-us58wwmp 3341 16 while while IN cord-015306-us58wwmp 3341 17 the the DT cord-015306-us58wwmp 3341 18 mean mean JJ cord-015306-us58wwmp 3341 19 IGFBP2SDS igfbp2sds NN cord-015306-us58wwmp 3341 20 ( ( -LRB- cord-015306-us58wwmp 3341 21 2.4 2.4 CD cord-015306-us58wwmp 3341 22 + + CC cord-015306-us58wwmp 3341 23 /-4.6 /-4.6 . cord-015306-us58wwmp 3341 24 ) ) -RRB- cord-015306-us58wwmp 3341 25 was be VBD cord-015306-us58wwmp 3341 26 significantly significantly RB cord-015306-us58wwmp 3341 27 higher high JJR cord-015306-us58wwmp 3341 28 in in IN cord-015306-us58wwmp 3341 29 patients patient NNS cord-015306-us58wwmp 3341 30 with with IN cord-015306-us58wwmp 3341 31 CRF CRF NNP cord-015306-us58wwmp 3341 32 than than IN cord-015306-us58wwmp 3341 33 in in IN cord-015306-us58wwmp 3341 34 controls control NNS cord-015306-us58wwmp 3341 35 . . . cord-015306-us58wwmp 3342 1 Height height NN cord-015306-us58wwmp 3342 2 and and CC cord-015306-us58wwmp 3342 3 weight weight NN cord-015306-us58wwmp 3342 4 were be VBD cord-015306-us58wwmp 3342 5 significantly significantly RB cord-015306-us58wwmp 3342 6 correlated correlate VBN cord-015306-us58wwmp 3342 7 to to IN cord-015306-us58wwmp 3342 8 IGF1 IGF1 NNP cord-015306-us58wwmp 3343 1 but but CC cord-015306-us58wwmp 3343 2 not not RB cord-015306-us58wwmp 3343 3 IGFBP2 igfbp2 CD cord-015306-us58wwmp 3343 4 . . . cord-015306-us58wwmp 3344 1 There there EX cord-015306-us58wwmp 3344 2 is be VBZ cord-015306-us58wwmp 3344 3 a a DT cord-015306-us58wwmp 3344 4 significant significant JJ cord-015306-us58wwmp 3344 5 correlation correlation NN cord-015306-us58wwmp 3344 6 between between IN cord-015306-us58wwmp 3344 7 IGFBP2 igfbp2 CD cord-015306-us58wwmp 3344 8 level level NN cord-015306-us58wwmp 3344 9 and and CC cord-015306-us58wwmp 3344 10 the the DT cord-015306-us58wwmp 3344 11 glomerular glomerular JJ cord-015306-us58wwmp 3344 12 filtration filtration NN cord-015306-us58wwmp 3344 13 rate rate NN cord-015306-us58wwmp 3344 14 . . . cord-015306-us58wwmp 3345 1 Conclusion conclusion NN cord-015306-us58wwmp 3345 2 : : : cord-015306-us58wwmp 3346 1 The the DT cord-015306-us58wwmp 3346 2 imbalance imbalance NN cord-015306-us58wwmp 3346 3 between between IN cord-015306-us58wwmp 3346 4 normal normal JJ cord-015306-us58wwmp 3346 5 insulin insulin NN cord-015306-us58wwmp 3346 6 - - HYPH cord-015306-us58wwmp 3346 7 like like JJ cord-015306-us58wwmp 3346 8 growth growth NN cord-015306-us58wwmp 3346 9 factor factor NN cord-015306-us58wwmp 3346 10 - - : cord-015306-us58wwmp 3346 11 I i NN cord-015306-us58wwmp 3346 12 ( ( -LRB- cord-015306-us58wwmp 3346 13 IGF IGF NNP cord-015306-us58wwmp 3346 14 - - HYPH cord-015306-us58wwmp 3346 15 I I NNP cord-015306-us58wwmp 3346 16 ) ) -RRB- cord-015306-us58wwmp 3346 17 and and CC cord-015306-us58wwmp 3346 18 markedly markedly RB cord-015306-us58wwmp 3346 19 increased increase VBN cord-015306-us58wwmp 3346 20 IGFBP2 igfbp2 NN cord-015306-us58wwmp 3346 21 plasma plasma NN cord-015306-us58wwmp 3346 22 levels level NNS cord-015306-us58wwmp 3346 23 plays play VBZ cord-015306-us58wwmp 3346 24 a a DT cord-015306-us58wwmp 3346 25 pathogenic pathogenic JJ cord-015306-us58wwmp 3346 26 role role NN cord-015306-us58wwmp 3346 27 for for IN cord-015306-us58wwmp 3346 28 growth growth NN cord-015306-us58wwmp 3346 29 retardation retardation NN cord-015306-us58wwmp 3346 30 in in IN cord-015306-us58wwmp 3346 31 children child NNS cord-015306-us58wwmp 3346 32 with with IN cord-015306-us58wwmp 3346 33 chronic chronic JJ cord-015306-us58wwmp 3346 34 renal renal JJ cord-015306-us58wwmp 3346 35 failure failure NN cord-015306-us58wwmp 3346 36 . . . cord-015306-us58wwmp 3347 1 The the DT cord-015306-us58wwmp 3347 2 lower low JJR cord-015306-us58wwmp 3347 3 the the DT cord-015306-us58wwmp 3347 4 GFR GFR NNP cord-015306-us58wwmp 3348 1 the the DT cord-015306-us58wwmp 3348 2 higher high JJR cord-015306-us58wwmp 3348 3 the the DT cord-015306-us58wwmp 3348 4 IGFBP2 igfbp2 CD cord-015306-us58wwmp 3348 5 level level NN cord-015306-us58wwmp 3348 6 . . . cord-015306-us58wwmp 3349 1 The the DT cord-015306-us58wwmp 3349 2 latters latter NNS cord-015306-us58wwmp 3349 3 inhibitory inhibitory JJ cord-015306-us58wwmp 3349 4 action action NN cord-015306-us58wwmp 3349 5 may may MD cord-015306-us58wwmp 3349 6 provide provide VB cord-015306-us58wwmp 3349 7 hope hope NN cord-015306-us58wwmp 3349 8 for for IN cord-015306-us58wwmp 3349 9 improving improve VBG cord-015306-us58wwmp 3349 10 growth growth NN cord-015306-us58wwmp 3349 11 in in IN cord-015306-us58wwmp 3349 12 cases case NNS cord-015306-us58wwmp 3349 13 of of IN cord-015306-us58wwmp 3349 14 CRF CRF NNP cord-015306-us58wwmp 3349 15 by by IN cord-015306-us58wwmp 3349 16 reducing reduce VBG cord-015306-us58wwmp 3349 17 the the DT cord-015306-us58wwmp 3349 18 level level NN cord-015306-us58wwmp 3349 19 of of IN cord-015306-us58wwmp 3349 20 IGFBP2 igfbp2 NN cord-015306-us58wwmp 3349 21 or or CC cord-015306-us58wwmp 3349 22 displacing displace VBG cord-015306-us58wwmp 3349 23 IGF1 IGF1 NNP cord-015306-us58wwmp 3349 24 from from IN cord-015306-us58wwmp 3349 25 it -PRON- PRP cord-015306-us58wwmp 3349 26 . . . cord-015306-us58wwmp 3350 1 Objective objective NN cord-015306-us58wwmp 3350 2 : : : cord-015306-us58wwmp 3351 1 Anemia anemia NN cord-015306-us58wwmp 3351 2 is be VBZ cord-015306-us58wwmp 3351 3 one one CD cord-015306-us58wwmp 3351 4 of of IN cord-015306-us58wwmp 3351 5 the the DT cord-015306-us58wwmp 3351 6 most most RBS cord-015306-us58wwmp 3351 7 common common JJ cord-015306-us58wwmp 3351 8 complications complication NNS cord-015306-us58wwmp 3351 9 of of IN cord-015306-us58wwmp 3351 10 chronic chronic JJ cord-015306-us58wwmp 3351 11 kidney kidney NN cord-015306-us58wwmp 3351 12 disease disease NN cord-015306-us58wwmp 3351 13 ( ( -LRB- cord-015306-us58wwmp 3351 14 CKD CKD NNP cord-015306-us58wwmp 3351 15 ) ) -RRB- cord-015306-us58wwmp 3351 16 and and CC cord-015306-us58wwmp 3351 17 renal renal JJ cord-015306-us58wwmp 3351 18 transplantation transplantation NN cord-015306-us58wwmp 3351 19 . . . cord-015306-us58wwmp 3352 1 This this DT cord-015306-us58wwmp 3352 2 study study NN cord-015306-us58wwmp 3352 3 evaluated evaluate VBD cord-015306-us58wwmp 3352 4 the the DT cord-015306-us58wwmp 3352 5 prevelance prevelance NN cord-015306-us58wwmp 3352 6 and and CC cord-015306-us58wwmp 3352 7 the the DT cord-015306-us58wwmp 3352 8 etiology etiology NN cord-015306-us58wwmp 3352 9 of of IN cord-015306-us58wwmp 3352 10 anemia anemia NN cord-015306-us58wwmp 3352 11 in in IN cord-015306-us58wwmp 3352 12 children child NNS cord-015306-us58wwmp 3352 13 with with IN cord-015306-us58wwmp 3352 14 stage stage NN cord-015306-us58wwmp 3352 15 I I NNP cord-015306-us58wwmp 3352 16 - - HYPH cord-015306-us58wwmp 3352 17 IV IV NNP cord-015306-us58wwmp 3352 18 CKD CKD NNP cord-015306-us58wwmp 3352 19 , , , cord-015306-us58wwmp 3352 20 end end NN cord-015306-us58wwmp 3352 21 - - HYPH cord-015306-us58wwmp 3352 22 stage stage NN cord-015306-us58wwmp 3352 23 renal renal JJ cord-015306-us58wwmp 3352 24 disease disease NN cord-015306-us58wwmp 3352 25 ( ( -LRB- cord-015306-us58wwmp 3352 26 ESRD ESRD NNP cord-015306-us58wwmp 3352 27 ) ) -RRB- cord-015306-us58wwmp 3352 28 and and CC cord-015306-us58wwmp 3352 29 renal renal JJ cord-015306-us58wwmp 3352 30 allograft allograft NN cord-015306-us58wwmp 3352 31 recipients recipient NNS cord-015306-us58wwmp 3352 32 . . . cord-015306-us58wwmp 3353 1 Methods method NNS cord-015306-us58wwmp 3353 2 : : : cord-015306-us58wwmp 3353 3 Between between IN cord-015306-us58wwmp 3353 4 2010 2010 CD cord-015306-us58wwmp 3353 5 and and CC cord-015306-us58wwmp 3353 6 2012 2012 CD cord-015306-us58wwmp 3353 7 , , , cord-015306-us58wwmp 3353 8 we -PRON- PRP cord-015306-us58wwmp 3353 9 prospectively prospectively RB cord-015306-us58wwmp 3353 10 followed follow VBD cord-015306-us58wwmp 3353 11 21 21 CD cord-015306-us58wwmp 3353 12 pediatric pediatric JJ cord-015306-us58wwmp 3353 13 stage stage NN cord-015306-us58wwmp 3353 14 I I NNP cord-015306-us58wwmp 3353 15 - - HYPH cord-015306-us58wwmp 3353 16 IV IV NNP cord-015306-us58wwmp 3353 17 CKD CKD NNP cord-015306-us58wwmp 3353 18 , , , cord-015306-us58wwmp 3353 19 20 20 CD cord-015306-us58wwmp 3353 20 ESRD ESRD NNP cord-015306-us58wwmp 3353 21 patients patient NNS cord-015306-us58wwmp 3353 22 and and CC cord-015306-us58wwmp 3353 23 27 27 CD cord-015306-us58wwmp 3353 24 renal renal JJ cord-015306-us58wwmp 3353 25 allograft allograft NN cord-015306-us58wwmp 3353 26 recipients recipient NNS cord-015306-us58wwmp 3353 27 . . . cord-015306-us58wwmp 3354 1 Anemia anemia NN cord-015306-us58wwmp 3354 2 was be VBD cord-015306-us58wwmp 3354 3 defined define VBN cord-015306-us58wwmp 3354 4 according accord VBG cord-015306-us58wwmp 3354 5 to to IN cord-015306-us58wwmp 3354 6 K K NNP cord-015306-us58wwmp 3354 7 / / SYM cord-015306-us58wwmp 3354 8 DOQI DOQI NNP cord-015306-us58wwmp 3354 9 guidelines guideline NNS cord-015306-us58wwmp 3354 10 as as IN cord-015306-us58wwmp 3354 11 Hb Hb NNP cord-015306-us58wwmp 3354 12 is be VBZ cord-015306-us58wwmp 3354 13 less less JJR cord-015306-us58wwmp 3354 14 than than IN cord-015306-us58wwmp 3354 15 the the DT cord-015306-us58wwmp 3354 16 fifth fifth JJ cord-015306-us58wwmp 3354 17 percentile percentile NN cord-015306-us58wwmp 3354 18 of of IN cord-015306-us58wwmp 3354 19 the the DT cord-015306-us58wwmp 3354 20 normal normal JJ cord-015306-us58wwmp 3354 21 , , , cord-015306-us58wwmp 3354 22 adjusted adjust VBN cord-015306-us58wwmp 3354 23 for for IN cord-015306-us58wwmp 3354 24 age age NN cord-015306-us58wwmp 3354 25 and and CC cord-015306-us58wwmp 3354 26 sex sex NN cord-015306-us58wwmp 3354 27 . . . cord-015306-us58wwmp 3355 1 Results result NNS cord-015306-us58wwmp 3355 2 : : : cord-015306-us58wwmp 3356 1 During during IN cord-015306-us58wwmp 3356 2 the the DT cord-015306-us58wwmp 3356 3 study study NN cord-015306-us58wwmp 3356 4 period52.3 period52.3 NNP cord-015306-us58wwmp 3356 5 % % NN cord-015306-us58wwmp 3356 6 of of IN cord-015306-us58wwmp 3356 7 stage stage NN cord-015306-us58wwmp 3356 8 I I NNP cord-015306-us58wwmp 3356 9 - - HYPH cord-015306-us58wwmp 3356 10 IV IV NNP cord-015306-us58wwmp 3356 11 CKD CKD NNP cord-015306-us58wwmp 3356 12 , , , cord-015306-us58wwmp 3356 13 100 100 CD cord-015306-us58wwmp 3356 14 % % NN cord-015306-us58wwmp 3356 15 of of IN cord-015306-us58wwmp 3356 16 ESRD ESRD NNP cord-015306-us58wwmp 3356 17 patients patient NNS cord-015306-us58wwmp 3356 18 and and CC cord-015306-us58wwmp 3356 19 48.1 48.1 CD cord-015306-us58wwmp 3356 20 % % NN cord-015306-us58wwmp 3356 21 of of IN cord-015306-us58wwmp 3356 22 renal renal JJ cord-015306-us58wwmp 3356 23 allograft allograft NN cord-015306-us58wwmp 3356 24 recipients recipient NNS cord-015306-us58wwmp 3356 25 developed develop VBD cord-015306-us58wwmp 3356 26 anemia anemia NN cord-015306-us58wwmp 3356 27 . . . cord-015306-us58wwmp 3357 1 The the DT cord-015306-us58wwmp 3357 2 mean mean JJ cord-015306-us58wwmp 3357 3 Hb Hb NNP cord-015306-us58wwmp 3357 4 levels level NNS cord-015306-us58wwmp 3357 5 were be VBD cord-015306-us58wwmp 3357 6 11.30+/-1.72 11.30+/-1.72 VBN cord-015306-us58wwmp 3357 7 g g NNP cord-015306-us58wwmp 3357 8 / / SYM cord-015306-us58wwmp 3357 9 dl dl NNP cord-015306-us58wwmp 3357 10 , , , cord-015306-us58wwmp 3357 11 9.62+/-1.94 9.62+/-1.94 CD cord-015306-us58wwmp 3357 12 g g NN cord-015306-us58wwmp 3357 13 / / SYM cord-015306-us58wwmp 3357 14 dl dl NN cord-015306-us58wwmp 3357 15 and and CC cord-015306-us58wwmp 3357 16 11.95+/-1.88 11.95+/-1.88 CD cord-015306-us58wwmp 3358 1 g g NNP cord-015306-us58wwmp 3358 2 / / SYM cord-015306-us58wwmp 3358 3 dl dl NN cord-015306-us58wwmp 3358 4 in in IN cord-015306-us58wwmp 3358 5 stage stage NN cord-015306-us58wwmp 3359 1 I -PRON- PRP cord-015306-us58wwmp 3359 2 - - HYPH cord-015306-us58wwmp 3359 3 IV IV NNP cord-015306-us58wwmp 3359 4 CKD CKD NNP cord-015306-us58wwmp 3359 5 , , , cord-015306-us58wwmp 3359 6 ESRD ESRD NNP cord-015306-us58wwmp 3359 7 patients patient NNS cord-015306-us58wwmp 3359 8 and and CC cord-015306-us58wwmp 3359 9 renal renal JJ cord-015306-us58wwmp 3359 10 allograft allograft NN cord-015306-us58wwmp 3359 11 recipients recipient NNS cord-015306-us58wwmp 3359 12 , , , cord-015306-us58wwmp 3359 13 respectively respectively RB cord-015306-us58wwmp 3359 14 . . . cord-015306-us58wwmp 3360 1 The the DT cord-015306-us58wwmp 3360 2 mean mean JJ cord-015306-us58wwmp 3360 3 Hb Hb NNP cord-015306-us58wwmp 3360 4 levels level NNS cord-015306-us58wwmp 3360 5 were be VBD cord-015306-us58wwmp 3360 6 significantly significantly RB cord-015306-us58wwmp 3360 7 lower low JJR cord-015306-us58wwmp 3360 8 in in IN cord-015306-us58wwmp 3360 9 ESRD ESRD NNP cord-015306-us58wwmp 3360 10 patients patient NNS cord-015306-us58wwmp 3360 11 as as IN cord-015306-us58wwmp 3360 12 compared compare VBN cord-015306-us58wwmp 3360 13 to to IN cord-015306-us58wwmp 3360 14 stage stage NN cord-015306-us58wwmp 3360 15 I I NNP cord-015306-us58wwmp 3360 16 - - HYPH cord-015306-us58wwmp 3360 17 IV IV NNP cord-015306-us58wwmp 3360 18 CKD CKD NNP cord-015306-us58wwmp 3360 19 patients patient NNS cord-015306-us58wwmp 3360 20 and and CC cord-015306-us58wwmp 3360 21 renal renal JJ cord-015306-us58wwmp 3360 22 allograft allograft NN cord-015306-us58wwmp 3360 23 recipients recipient NNS cord-015306-us58wwmp 3360 24 ( ( -LRB- cord-015306-us58wwmp 3360 25 p<0.0081 p<0.0081 NNP cord-015306-us58wwmp 3360 26 , , , cord-015306-us58wwmp 3360 27 p<0.002 p<0.002 CD cord-015306-us58wwmp 3360 28 ) ) -RRB- cord-015306-us58wwmp 3360 29 . . . cord-015306-us58wwmp 3361 1 Erythropoetine Erythropoetine NNP cord-015306-us58wwmp 3361 2 ( ( -LRB- cord-015306-us58wwmp 3361 3 EPO EPO NNP cord-015306-us58wwmp 3361 4 ) ) -RRB- cord-015306-us58wwmp 3361 5 deficiency deficiency NN cord-015306-us58wwmp 3361 6 was be VBD cord-015306-us58wwmp 3361 7 the the DT cord-015306-us58wwmp 3361 8 most most RBS cord-015306-us58wwmp 3361 9 frequent frequent JJ cord-015306-us58wwmp 3361 10 cause cause NN cord-015306-us58wwmp 3361 11 of of IN cord-015306-us58wwmp 3361 12 anemia anemia NN cord-015306-us58wwmp 3361 13 in in IN cord-015306-us58wwmp 3361 14 stage stage NN cord-015306-us58wwmp 3362 1 I -PRON- PRP cord-015306-us58wwmp 3362 2 - - HYPH cord-015306-us58wwmp 3362 3 IV IV NNP cord-015306-us58wwmp 3362 4 CKD CKD NNP cord-015306-us58wwmp 3362 5 and and CC cord-015306-us58wwmp 3362 6 ESRD ESRD NNP cord-015306-us58wwmp 3362 7 patients patient NNS cord-015306-us58wwmp 3362 8 , , , cord-015306-us58wwmp 3362 9 followed follow VBN cord-015306-us58wwmp 3362 10 by by IN cord-015306-us58wwmp 3362 11 iron iron NN cord-015306-us58wwmp 3362 12 deficiency deficiency NN cord-015306-us58wwmp 3362 13 . . . cord-015306-us58wwmp 3363 1 In in IN cord-015306-us58wwmp 3363 2 addition addition NN cord-015306-us58wwmp 3363 3 to to IN cord-015306-us58wwmp 3363 4 EPO EPO NNP cord-015306-us58wwmp 3363 5 and and CC cord-015306-us58wwmp 3363 6 iron iron NN cord-015306-us58wwmp 3363 7 deficiency deficiency NN cord-015306-us58wwmp 3363 8 , , , cord-015306-us58wwmp 3363 9 bone bone NN cord-015306-us58wwmp 3363 10 marrow marrow NN cord-015306-us58wwmp 3363 11 suppression suppression NN cord-015306-us58wwmp 3363 12 and and CC cord-015306-us58wwmp 3363 13 parvovirus parvovirus NN cord-015306-us58wwmp 3363 14 infection infection NN cord-015306-us58wwmp 3363 15 were be VBD cord-015306-us58wwmp 3363 16 the the DT cord-015306-us58wwmp 3363 17 causes cause NNS cord-015306-us58wwmp 3363 18 of of IN cord-015306-us58wwmp 3363 19 anemia anemia NN cord-015306-us58wwmp 3363 20 in in IN cord-015306-us58wwmp 3363 21 renal renal JJ cord-015306-us58wwmp 3363 22 allograft allograft NN cord-015306-us58wwmp 3363 23 recipients recipient NNS cord-015306-us58wwmp 3363 24 . . . cord-015306-us58wwmp 3364 1 Erythropoietic erythropoietic JJ cord-015306-us58wwmp 3364 2 stimulating stimulating JJ cord-015306-us58wwmp 3364 3 agents agent NNS cord-015306-us58wwmp 3364 4 were be VBD cord-015306-us58wwmp 3364 5 used use VBN cord-015306-us58wwmp 3364 6 in in IN cord-015306-us58wwmp 3364 7 27 27 CD cord-015306-us58wwmp 3364 8 % % NN cord-015306-us58wwmp 3364 9 of of IN cord-015306-us58wwmp 3364 10 stage stage NN cord-015306-us58wwmp 3364 11 I I NNP cord-015306-us58wwmp 3364 12 - - HYPH cord-015306-us58wwmp 3364 13 IV IV NNP cord-015306-us58wwmp 3364 14 CKD CKD NNP cord-015306-us58wwmp 3364 15 , , , cord-015306-us58wwmp 3364 16 100 100 CD cord-015306-us58wwmp 3364 17 % % NN cord-015306-us58wwmp 3364 18 of of IN cord-015306-us58wwmp 3364 19 ESRD ESRD NNP cord-015306-us58wwmp 3364 20 patients patient NNS cord-015306-us58wwmp 3364 21 and and CC cord-015306-us58wwmp 3364 22 23 23 CD cord-015306-us58wwmp 3364 23 % % NN cord-015306-us58wwmp 3364 24 of of IN cord-015306-us58wwmp 3364 25 the the DT cord-015306-us58wwmp 3364 26 renal renal JJ cord-015306-us58wwmp 3364 27 allograft allograft NN cord-015306-us58wwmp 3364 28 recipients recipient NNS cord-015306-us58wwmp 3364 29 . . . cord-015306-us58wwmp 3365 1 Conclusion conclusion NN cord-015306-us58wwmp 3365 2 : : : cord-015306-us58wwmp 3366 1 Although although IN cord-015306-us58wwmp 3366 2 anemia anemia NN cord-015306-us58wwmp 3366 3 is be VBZ cord-015306-us58wwmp 3366 4 one one NN cord-015306-us58wwmp 3366 5 the the DT cord-015306-us58wwmp 3366 6 most most RBS cord-015306-us58wwmp 3366 7 common common JJ cord-015306-us58wwmp 3366 8 problems problem NNS cord-015306-us58wwmp 3366 9 seen see VBN cord-015306-us58wwmp 3366 10 in in IN cord-015306-us58wwmp 3366 11 children child NNS cord-015306-us58wwmp 3366 12 with with IN cord-015306-us58wwmp 3366 13 CKD CKD NNP cord-015306-us58wwmp 3366 14 and and CC cord-015306-us58wwmp 3366 15 ESRD ESRD NNP cord-015306-us58wwmp 3366 16 , , , cord-015306-us58wwmp 3366 17 the the DT cord-015306-us58wwmp 3366 18 prevelance prevelance NN cord-015306-us58wwmp 3366 19 is be VBZ cord-015306-us58wwmp 3366 20 also also RB cord-015306-us58wwmp 3366 21 high high JJ cord-015306-us58wwmp 3366 22 in in IN cord-015306-us58wwmp 3366 23 renal renal JJ cord-015306-us58wwmp 3366 24 allograft allograft NN cord-015306-us58wwmp 3366 25 recipients recipient NNS cord-015306-us58wwmp 3366 26 . . . cord-015306-us58wwmp 3367 1 These these DT cord-015306-us58wwmp 3367 2 patients patient NNS cord-015306-us58wwmp 3367 3 should should MD cord-015306-us58wwmp 3367 4 be be VB cord-015306-us58wwmp 3367 5 evaluated evaluate VBN cord-015306-us58wwmp 3367 6 and and CC cord-015306-us58wwmp 3367 7 treated treat VBN cord-015306-us58wwmp 3367 8 accordingly accordingly RB cord-015306-us58wwmp 3367 9 to to IN cord-015306-us58wwmp 3367 10 the the DT cord-015306-us58wwmp 3367 11 underlying underlie VBG cord-015306-us58wwmp 3367 12 causes cause NNS cord-015306-us58wwmp 3367 13 . . . cord-015306-us58wwmp 3368 1 Abstract abstract JJ cord-015306-us58wwmp 3368 2 # # NN cord-015306-us58wwmp 3368 3 P p NN cord-015306-us58wwmp 3368 4 - - HYPH cord-015306-us58wwmp 3368 5 SAT375 SAT375 NNP cord-015306-us58wwmp 3368 6 Determinants determinant NNS cord-015306-us58wwmp 3368 7 and and CC cord-015306-us58wwmp 3368 8 prevalence prevalence NN cord-015306-us58wwmp 3368 9 of of IN cord-015306-us58wwmp 3368 10 anaemia anaemia NN cord-015306-us58wwmp 3368 11 among among IN cord-015306-us58wwmp 3368 12 preschool preschool NN cord-015306-us58wwmp 3368 13 children child NNS cord-015306-us58wwmp 3368 14 in in IN cord-015306-us58wwmp 3368 15 highly highly RB cord-015306-us58wwmp 3368 16 focussed focusse VBN cord-015306-us58wwmp 3368 17 states state NNS cord-015306-us58wwmp 3368 18 of of IN cord-015306-us58wwmp 3368 19 India India NNP cord-015306-us58wwmp 3368 20 Results Results NNPS cord-015306-us58wwmp 3368 21 : : : cord-015306-us58wwmp 3368 22 About about IN cord-015306-us58wwmp 3368 23 more more JJR cord-015306-us58wwmp 3368 24 than than IN cord-015306-us58wwmp 3368 25 60 60 CD cord-015306-us58wwmp 3368 26 % % NN cord-015306-us58wwmp 3368 27 child child NN cord-015306-us58wwmp 3368 28 is be VBZ cord-015306-us58wwmp 3368 29 anaemic anaemic JJ cord-015306-us58wwmp 3368 30 among among IN cord-015306-us58wwmp 3368 31 all all DT cord-015306-us58wwmp 3368 32 EAG EAG NNP cord-015306-us58wwmp 3368 33 States States NNPS cord-015306-us58wwmp 3368 34 . . . cord-015306-us58wwmp 3369 1 The the DT cord-015306-us58wwmp 3369 2 prevalence prevalence NN cord-015306-us58wwmp 3369 3 of of IN cord-015306-us58wwmp 3369 4 severe severe JJ cord-015306-us58wwmp 3369 5 anaemia anaemia NN cord-015306-us58wwmp 3369 6 is be VBZ cord-015306-us58wwmp 3369 7 6.7 6.7 CD cord-015306-us58wwmp 3369 8 % % NN cord-015306-us58wwmp 3369 9 in in IN cord-015306-us58wwmp 3369 10 Rajasthan Rajasthan NNP cord-015306-us58wwmp 3369 11 followed follow VBN cord-015306-us58wwmp 3369 12 by by IN cord-015306-us58wwmp 3369 13 Uttar Uttar NNP cord-015306-us58wwmp 3369 14 Pradesh Pradesh NNP cord-015306-us58wwmp 3369 15 ( ( -LRB- cord-015306-us58wwmp 3369 16 3.6 3.6 CD cord-015306-us58wwmp 3369 17 % % NN cord-015306-us58wwmp 3369 18 ) ) -RRB- cord-015306-us58wwmp 3369 19 and and CC cord-015306-us58wwmp 3369 20 Madhya Madhya NNP cord-015306-us58wwmp 3369 21 Pradesh Pradesh NNP cord-015306-us58wwmp 3369 22 ( ( -LRB- cord-015306-us58wwmp 3369 23 3.4 3.4 CD cord-015306-us58wwmp 3369 24 % % NN cord-015306-us58wwmp 3369 25 ) ) -RRB- cord-015306-us58wwmp 3369 26 . . . cord-015306-us58wwmp 3370 1 Those those DT cord-015306-us58wwmp 3370 2 children child NNS cord-015306-us58wwmp 3370 3 aged age VBN cord-015306-us58wwmp 3370 4 12 12 CD cord-015306-us58wwmp 3370 5 to to TO cord-015306-us58wwmp 3370 6 17 17 CD cord-015306-us58wwmp 3370 7 months month NNS cord-015306-us58wwmp 3370 8 are be VBP cord-015306-us58wwmp 3370 9 7 7 CD cord-015306-us58wwmp 3370 10 times time NNS cord-015306-us58wwmp 3370 11 significantly significantly RB cord-015306-us58wwmp 3370 12 more more RBR cord-015306-us58wwmp 3370 13 likely likely JJ cord-015306-us58wwmp 3370 14 to to TO cord-015306-us58wwmp 3370 15 be be VB cord-015306-us58wwmp 3370 16 severe severe JJ cord-015306-us58wwmp 3370 17 anaemic anaemic JJ cord-015306-us58wwmp 3370 18 as as IN cord-015306-us58wwmp 3370 19 compare compare VBP cord-015306-us58wwmp 3370 20 to to IN cord-015306-us58wwmp 3370 21 the the DT cord-015306-us58wwmp 3370 22 36 36 CD cord-015306-us58wwmp 3370 23 to to TO cord-015306-us58wwmp 3370 24 59 59 CD cord-015306-us58wwmp 3370 25 months month NNS cord-015306-us58wwmp 3370 26 aged age VBN cord-015306-us58wwmp 3370 27 children child NNS cord-015306-us58wwmp 3370 28 . . . cord-015306-us58wwmp 3371 1 Those those DT cord-015306-us58wwmp 3371 2 mothers mother NNS cord-015306-us58wwmp 3371 3 have have VBP cord-015306-us58wwmp 3371 4 severe severe JJ cord-015306-us58wwmp 3371 5 anaemia anaemia NN cord-015306-us58wwmp 3371 6 , , , cord-015306-us58wwmp 3371 7 their -PRON- PRP$ cord-015306-us58wwmp 3371 8 children child NNS cord-015306-us58wwmp 3371 9 are be VBP cord-015306-us58wwmp 3371 10 also also RB cord-015306-us58wwmp 3371 11 found find VBN cord-015306-us58wwmp 3371 12 to to TO cord-015306-us58wwmp 3371 13 be be VB cord-015306-us58wwmp 3371 14 severe severe JJ cord-015306-us58wwmp 3371 15 anaemic anaemic JJ cord-015306-us58wwmp 3371 16 ( ( -LRB- cord-015306-us58wwmp 3371 17 16 16 CD cord-015306-us58wwmp 3371 18 times time NNS cord-015306-us58wwmp 3371 19 more more JJR cord-015306-us58wwmp 3371 20 than than IN cord-015306-us58wwmp 3371 21 not not RB cord-015306-us58wwmp 3371 22 anaemic anaemic JJ cord-015306-us58wwmp 3371 23 mothers mother NNS cord-015306-us58wwmp 3371 24 ) ) -RRB- cord-015306-us58wwmp 3371 25 . . . cord-015306-us58wwmp 3372 1 Mothers mother NNS cord-015306-us58wwmp 3372 2 who who WP cord-015306-us58wwmp 3372 3 are be VBP cord-015306-us58wwmp 3372 4 highly highly RB cord-015306-us58wwmp 3372 5 educated educate VBN cord-015306-us58wwmp 3372 6 and and CC cord-015306-us58wwmp 3372 7 belong belong VB cord-015306-us58wwmp 3372 8 to to IN cord-015306-us58wwmp 3372 9 richest rich JJS cord-015306-us58wwmp 3372 10 quintile quintile NN cord-015306-us58wwmp 3373 1 their -PRON- PRP$ cord-015306-us58wwmp 3373 2 children child NNS cord-015306-us58wwmp 3373 3 are be VBP cord-015306-us58wwmp 3373 4 less less RBR cord-015306-us58wwmp 3373 5 likely likely JJ cord-015306-us58wwmp 3373 6 to to TO cord-015306-us58wwmp 3373 7 be be VB cord-015306-us58wwmp 3373 8 anaemic anaemic JJ cord-015306-us58wwmp 3373 9 . . . cord-015306-us58wwmp 3374 1 The the DT cord-015306-us58wwmp 3374 2 finding finding NN cord-015306-us58wwmp 3374 3 of of IN cord-015306-us58wwmp 3374 4 the the DT cord-015306-us58wwmp 3374 5 study study NN cord-015306-us58wwmp 3374 6 shows show VBZ cord-015306-us58wwmp 3374 7 that that IN cord-015306-us58wwmp 3374 8 demographic demographic JJ cord-015306-us58wwmp 3374 9 and and CC cord-015306-us58wwmp 3374 10 socio socio JJ cord-015306-us58wwmp 3374 11 - - JJ cord-015306-us58wwmp 3374 12 economic economic JJ cord-015306-us58wwmp 3374 13 indicators indicator NNS cord-015306-us58wwmp 3374 14 play play VBP cord-015306-us58wwmp 3374 15 significant significant JJ cord-015306-us58wwmp 3374 16 role role NN cord-015306-us58wwmp 3374 17 in in IN cord-015306-us58wwmp 3374 18 determining determine VBG cord-015306-us58wwmp 3374 19 the the DT cord-015306-us58wwmp 3374 20 prevalence prevalence NN cord-015306-us58wwmp 3374 21 of of IN cord-015306-us58wwmp 3374 22 anaemia anaemia NN cord-015306-us58wwmp 3374 23 in in IN cord-015306-us58wwmp 3374 24 EAG EAG NNP cord-015306-us58wwmp 3374 25 states state NNS cord-015306-us58wwmp 3374 26 which which WDT cord-015306-us58wwmp 3374 27 needs need VBZ cord-015306-us58wwmp 3374 28 focused focused JJ cord-015306-us58wwmp 3374 29 programme programme NN cord-015306-us58wwmp 3374 30 to to TO cord-015306-us58wwmp 3374 31 reduce reduce VB cord-015306-us58wwmp 3374 32 the the DT cord-015306-us58wwmp 3374 33 prevalence prevalence NN cord-015306-us58wwmp 3374 34 of of IN cord-015306-us58wwmp 3374 35 anaemia anaemia NN cord-015306-us58wwmp 3374 36 in in IN cord-015306-us58wwmp 3374 37 preschool preschool NN cord-015306-us58wwmp 3374 38 children child NNS cord-015306-us58wwmp 3374 39 . . . cord-015306-us58wwmp 3375 1 Abstract abstract JJ cord-015306-us58wwmp 3375 2 # # NN cord-015306-us58wwmp 3375 3 P p NN cord-015306-us58wwmp 3375 4 - - HYPH cord-015306-us58wwmp 3375 5 SAT376 SAT376 NNP cord-015306-us58wwmp 3376 1 Impaired impaired JJ cord-015306-us58wwmp 3376 2 renal renal JJ cord-015306-us58wwmp 3376 3 growth growth NN cord-015306-us58wwmp 3376 4 hormone hormone NN cord-015306-us58wwmp 3376 5 mediated mediate VBN cord-015306-us58wwmp 3377 1 JAK JAK NNP cord-015306-us58wwmp 3377 2 / / SYM cord-015306-us58wwmp 3377 3 STAT5 STAT5 NNP cord-015306-us58wwmp 3377 4 signaling signal VBG cord-015306-us58wwmp 3377 5 in in IN cord-015306-us58wwmp 3377 6 juvenile juvenile JJ cord-015306-us58wwmp 3377 7 rats rat NNS cord-015306-us58wwmp 3377 8 with with IN cord-015306-us58wwmp 3377 9 chronic chronic JJ cord-015306-us58wwmp 3377 10 kidney kidney NN cord-015306-us58wwmp 3377 11 disease disease NN cord-015306-us58wwmp 3377 12 Objective Objective NNP cord-015306-us58wwmp 3378 1 : : : cord-015306-us58wwmp 3378 2 Linear linear JJ cord-015306-us58wwmp 3378 3 growth growth NN cord-015306-us58wwmp 3378 4 retardation retardation NN cord-015306-us58wwmp 3378 5 is be VBZ cord-015306-us58wwmp 3378 6 a a DT cord-015306-us58wwmp 3378 7 major major JJ cord-015306-us58wwmp 3378 8 problem problem NN cord-015306-us58wwmp 3378 9 in in IN cord-015306-us58wwmp 3378 10 children child NNS cord-015306-us58wwmp 3378 11 with with IN cord-015306-us58wwmp 3378 12 chronic chronic JJ cord-015306-us58wwmp 3378 13 kidney kidney NN cord-015306-us58wwmp 3378 14 disease disease NN cord-015306-us58wwmp 3378 15 ( ( -LRB- cord-015306-us58wwmp 3378 16 CKD CKD NNP cord-015306-us58wwmp 3378 17 ) ) -RRB- cord-015306-us58wwmp 3378 18 and and CC cord-015306-us58wwmp 3378 19 is be VBZ cord-015306-us58wwmp 3378 20 ascribed ascribe VBN cord-015306-us58wwmp 3378 21 to to IN cord-015306-us58wwmp 3378 22 GH GH NNP cord-015306-us58wwmp 3378 23 insensitivity insensitivity NN cord-015306-us58wwmp 3378 24 . . . cord-015306-us58wwmp 3379 1 Treatment treatment NN cord-015306-us58wwmp 3379 2 with with IN cord-015306-us58wwmp 3379 3 exogenous exogenous JJ cord-015306-us58wwmp 3379 4 GH GH NNP cord-015306-us58wwmp 3379 5 has have VBZ cord-015306-us58wwmp 3379 6 been be VBN cord-015306-us58wwmp 3379 7 accepted accept VBN cord-015306-us58wwmp 3379 8 as as IN cord-015306-us58wwmp 3379 9 standard standard JJ cord-015306-us58wwmp 3379 10 therapy therapy NN cord-015306-us58wwmp 3379 11 in in IN cord-015306-us58wwmp 3379 12 children child NNS cord-015306-us58wwmp 3379 13 with with IN cord-015306-us58wwmp 3379 14 CKD CKD NNP cord-015306-us58wwmp 3379 15 and and CC cord-015306-us58wwmp 3379 16 short short JJ cord-015306-us58wwmp 3379 17 stature stature NN cord-015306-us58wwmp 3379 18 . . . cord-015306-us58wwmp 3380 1 However however RB cord-015306-us58wwmp 3380 2 , , , cord-015306-us58wwmp 3380 3 concerns concern NNS cord-015306-us58wwmp 3380 4 have have VBP cord-015306-us58wwmp 3380 5 been be VBN cord-015306-us58wwmp 3380 6 raised raise VBN cord-015306-us58wwmp 3380 7 in in IN cord-015306-us58wwmp 3380 8 the the DT cord-015306-us58wwmp 3380 9 past past NN cord-015306-us58wwmp 3380 10 on on IN cord-015306-us58wwmp 3380 11 the the DT cord-015306-us58wwmp 3380 12 potential potential JJ cord-015306-us58wwmp 3380 13 fibrogenic fibrogenic JJ cord-015306-us58wwmp 3380 14 effects effect NNS cord-015306-us58wwmp 3380 15 of of IN cord-015306-us58wwmp 3380 16 GH GH NNP cord-015306-us58wwmp 3380 17 . . . cord-015306-us58wwmp 3381 1 There there EX cord-015306-us58wwmp 3381 2 is be VBZ cord-015306-us58wwmp 3381 3 no no DT cord-015306-us58wwmp 3381 4 information information NN cord-015306-us58wwmp 3381 5 regarding regard VBG cord-015306-us58wwmp 3381 6 renal renal JJ cord-015306-us58wwmp 3381 7 GHR GHR NNP cord-015306-us58wwmp 3381 8 signaling signal VBG cord-015306-us58wwmp 3381 9 pathway pathway NN cord-015306-us58wwmp 3381 10 in in IN cord-015306-us58wwmp 3381 11 CKD CKD NNP cord-015306-us58wwmp 3381 12 . . . cord-015306-us58wwmp 3382 1 Methods method NNS cord-015306-us58wwmp 3382 2 and and CC cord-015306-us58wwmp 3382 3 Results result NNS cord-015306-us58wwmp 3382 4 : : : cord-015306-us58wwmp 3382 5 To to TO cord-015306-us58wwmp 3382 6 investigate investigate VB cord-015306-us58wwmp 3382 7 this this DT cord-015306-us58wwmp 3382 8 pathway pathway NN cord-015306-us58wwmp 3382 9 , , , cord-015306-us58wwmp 3382 10 surgically surgically RB cord-015306-us58wwmp 3382 11 5/6 5/6 CD cord-015306-us58wwmp 3382 12 nephrectomized nephrectomized JJ cord-015306-us58wwmp 3382 13 ( ( -LRB- cord-015306-us58wwmp 3382 14 CKD CKD NNP cord-015306-us58wwmp 3382 15 ) ) -RRB- cord-015306-us58wwmp 3382 16 and and CC cord-015306-us58wwmp 3382 17 pair pair NN cord-015306-us58wwmp 3382 18 - - HYPH cord-015306-us58wwmp 3382 19 fed feed VBN cord-015306-us58wwmp 3382 20 control control NN cord-015306-us58wwmp 3382 21 ( ( -LRB- cord-015306-us58wwmp 3382 22 C C NNP cord-015306-us58wwmp 3382 23 ) ) -RRB- cord-015306-us58wwmp 3382 24 juvenile juvenile NN cord-015306-us58wwmp 3382 25 ( ( -LRB- cord-015306-us58wwmp 3382 26 3 3 CD cord-015306-us58wwmp 3382 27 wk wk NN cord-015306-us58wwmp 3382 28 old old JJ cord-015306-us58wwmp 3382 29 ) ) -RRB- cord-015306-us58wwmp 3382 30 rats rat NNS cord-015306-us58wwmp 3382 31 were be VBD cord-015306-us58wwmp 3382 32 sacrificed sacrifice VBN cord-015306-us58wwmp 3382 33 after after IN cord-015306-us58wwmp 3382 34 2 2 CD cord-015306-us58wwmp 3382 35 weeks week NNS cord-015306-us58wwmp 3382 36 of of IN cord-015306-us58wwmp 3382 37 CKD CKD NNP cord-015306-us58wwmp 3382 38 . . . cord-015306-us58wwmp 3383 1 Serum serum NN cord-015306-us58wwmp 3383 2 creatinine creatinine NN cord-015306-us58wwmp 3383 3 and and CC cord-015306-us58wwmp 3383 4 albumin albumin NN cord-015306-us58wwmp 3383 5 excretion excretion NN cord-015306-us58wwmp 3383 6 were be VBD cord-015306-us58wwmp 3383 7 significantly significantly RB cord-015306-us58wwmp 3383 8 elevated elevate VBN cord-015306-us58wwmp 3383 9 ( ( -LRB- cord-015306-us58wwmp 3383 10 associated associate VBN cord-015306-us58wwmp 3383 11 with with IN cord-015306-us58wwmp 3383 12 glomerulomegaly glomerulomegaly NNP cord-015306-us58wwmp 3383 13 and and CC cord-015306-us58wwmp 3383 14 early early JJ cord-015306-us58wwmp 3383 15 fibrosis fibrosis NN cord-015306-us58wwmp 3383 16 ) ) -RRB- cord-015306-us58wwmp 3383 17 while while IN cord-015306-us58wwmp 3383 18 body body NN cord-015306-us58wwmp 3383 19 weight weight NN cord-015306-us58wwmp 3383 20 and and CC cord-015306-us58wwmp 3383 21 length length NN cord-015306-us58wwmp 3383 22 gain gain NN cord-015306-us58wwmp 3383 23 were be VBD cord-015306-us58wwmp 3383 24 reduced reduce VBN cord-015306-us58wwmp 3383 25 in in IN cord-015306-us58wwmp 3383 26 CKD CKD NNP cord-015306-us58wwmp 3383 27 rats rat NNS cord-015306-us58wwmp 3383 28 . . . cord-015306-us58wwmp 3384 1 Serum serum NN cord-015306-us58wwmp 3384 2 IGF IGF NNP cord-015306-us58wwmp 3384 3 - - HYPH cord-015306-us58wwmp 3384 4 I -PRON- PRP cord-015306-us58wwmp 3384 5 levels level NNS cord-015306-us58wwmp 3384 6 were be VBD cord-015306-us58wwmp 3384 7 decreased decrease VBN cord-015306-us58wwmp 3384 8 in in IN cord-015306-us58wwmp 3384 9 CKD CKD NNP cord-015306-us58wwmp 3384 10 , , , cord-015306-us58wwmp 3384 11 even even RB cord-015306-us58wwmp 3384 12 though though IN cord-015306-us58wwmp 3384 13 serum serum NN cord-015306-us58wwmp 3384 14 GH gh NN cord-015306-us58wwmp 3384 15 levels level NNS cord-015306-us58wwmp 3384 16 were be VBD cord-015306-us58wwmp 3384 17 unchanged unchanged JJ cord-015306-us58wwmp 3384 18 . . . cord-015306-us58wwmp 3385 1 Kidney kidney NN cord-015306-us58wwmp 3385 2 GHR GHR NNP cord-015306-us58wwmp 3385 3 mRNA mRNA NNP cord-015306-us58wwmp 3385 4 and and CC cord-015306-us58wwmp 3385 5 protein protein NN cord-015306-us58wwmp 3385 6 levels level NNS cord-015306-us58wwmp 3385 7 were be VBD cord-015306-us58wwmp 3385 8 reduced reduce VBN cord-015306-us58wwmp 3385 9 and and CC cord-015306-us58wwmp 3385 10 phosphorylation phosphorylation NN cord-015306-us58wwmp 3385 11 of of IN cord-015306-us58wwmp 3385 12 JAK2 JAK2 NNP cord-015306-us58wwmp 3385 13 and and CC cord-015306-us58wwmp 3385 14 STAT5 STAT5 NNP cord-015306-us58wwmp 3385 15 was be VBD cord-015306-us58wwmp 3385 16 significantly significantly RB cord-015306-us58wwmp 3385 17 impaired impair VBN cord-015306-us58wwmp 3385 18 . . . cord-015306-us58wwmp 3386 1 Supressor supressor NN cord-015306-us58wwmp 3386 2 of of IN cord-015306-us58wwmp 3386 3 cytokine cytokine NN cord-015306-us58wwmp 3386 4 signaling signaling NN cord-015306-us58wwmp 3386 5 ( ( -LRB- cord-015306-us58wwmp 3386 6 SOCS3 SOCS3 NNP cord-015306-us58wwmp 3386 7 ) ) -RRB- cord-015306-us58wwmp 3387 1 mRNA mRNA NNP cord-015306-us58wwmp 3387 2 was be VBD cord-015306-us58wwmp 3387 3 increased increase VBN cord-015306-us58wwmp 3387 4 in in IN cord-015306-us58wwmp 3387 5 association association NN cord-015306-us58wwmp 3387 6 of of IN cord-015306-us58wwmp 3387 7 increase increase NN cord-015306-us58wwmp 3387 8 in in IN cord-015306-us58wwmp 3387 9 renal renal JJ cord-015306-us58wwmp 3387 10 IL6 IL6 NNP cord-015306-us58wwmp 3387 11 mRNA mRNA NNP cord-015306-us58wwmp 3387 12 . . . cord-015306-us58wwmp 3388 1 Renal Renal NNP cord-015306-us58wwmp 3388 2 IGF-1 IGF-1 NNP cord-015306-us58wwmp 3388 3 mRNA mrna NN cord-015306-us58wwmp 3388 4 was be VBD cord-015306-us58wwmp 3388 5 unaltered unaltered JJ cord-015306-us58wwmp 3388 6 in in IN cord-015306-us58wwmp 3388 7 CKD CKD NNP cord-015306-us58wwmp 3388 8 . . . cord-015306-us58wwmp 3389 1 Thus thus RB cord-015306-us58wwmp 3389 2 , , , cord-015306-us58wwmp 3389 3 in in IN cord-015306-us58wwmp 3389 4 the the DT cord-015306-us58wwmp 3389 5 remnant remnant JJ cord-015306-us58wwmp 3389 6 kidney kidney NN cord-015306-us58wwmp 3389 7 of of IN cord-015306-us58wwmp 3389 8 CKD CKD NNP cord-015306-us58wwmp 3389 9 growth growth NN cord-015306-us58wwmp 3389 10 retarded retard VBD cord-015306-us58wwmp 3389 11 juvenile juvenile JJ cord-015306-us58wwmp 3389 12 rats rat NNS cord-015306-us58wwmp 3389 13 there there EX cord-015306-us58wwmp 3389 14 is be VBZ cord-015306-us58wwmp 3389 15 impaired impair VBN cord-015306-us58wwmp 3389 16 GH GH NNP cord-015306-us58wwmp 3389 17 mediated mediate VBD cord-015306-us58wwmp 3389 18 JAK2 JAK2 NNP cord-015306-us58wwmp 3389 19 / / SYM cord-015306-us58wwmp 3389 20 STAT5 stat5 NN cord-015306-us58wwmp 3389 21 signaling signal VBG cord-015306-us58wwmp 3389 22 . . . cord-015306-us58wwmp 3390 1 This this DT cord-015306-us58wwmp 3390 2 defect defect NN cord-015306-us58wwmp 3390 3 may may MD cord-015306-us58wwmp 3390 4 be be VB cord-015306-us58wwmp 3390 5 due due JJ cord-015306-us58wwmp 3390 6 to to IN cord-015306-us58wwmp 3390 7 a a DT cord-015306-us58wwmp 3390 8 reduction reduction NN cord-015306-us58wwmp 3390 9 in in IN cord-015306-us58wwmp 3390 10 GH GH NNP cord-015306-us58wwmp 3390 11 receptor receptor NN cord-015306-us58wwmp 3390 12 expression expression NN cord-015306-us58wwmp 3390 13 and and CC cord-015306-us58wwmp 3390 14 signaling signal VBG cord-015306-us58wwmp 3390 15 together together RB cord-015306-us58wwmp 3390 16 with with IN cord-015306-us58wwmp 3390 17 an an DT cord-015306-us58wwmp 3390 18 increase increase NN cord-015306-us58wwmp 3390 19 in in IN cord-015306-us58wwmp 3390 20 SOCS3 socs3 JJ cord-015306-us58wwmp 3390 21 expression expression NN cord-015306-us58wwmp 3390 22 . . . cord-015306-us58wwmp 3391 1 Conclusion conclusion NN cord-015306-us58wwmp 3391 2 : : : cord-015306-us58wwmp 3391 3 We -PRON- PRP cord-015306-us58wwmp 3391 4 suggest suggest VBP cord-015306-us58wwmp 3391 5 that that IN cord-015306-us58wwmp 3391 6 the the DT cord-015306-us58wwmp 3391 7 insensitivity insensitivity NN cord-015306-us58wwmp 3391 8 of of IN cord-015306-us58wwmp 3391 9 the the DT cord-015306-us58wwmp 3391 10 remnant remnant JJ cord-015306-us58wwmp 3391 11 kidney kidney NN cord-015306-us58wwmp 3391 12 to to IN cord-015306-us58wwmp 3391 13 GH GH NNP cord-015306-us58wwmp 3391 14 may may MD cord-015306-us58wwmp 3391 15 serve serve VB cord-015306-us58wwmp 3391 16 to to TO cord-015306-us58wwmp 3391 17 protect protect VB cord-015306-us58wwmp 3391 18 against against IN cord-015306-us58wwmp 3391 19 the the DT cord-015306-us58wwmp 3391 20 potential potential JJ cord-015306-us58wwmp 3391 21 adverse adverse JJ cord-015306-us58wwmp 3391 22 renal renal JJ cord-015306-us58wwmp 3391 23 effects effect NNS cord-015306-us58wwmp 3391 24 of of IN cord-015306-us58wwmp 3391 25 exogenous exogenous JJ cord-015306-us58wwmp 3391 26 GH GH NNP cord-015306-us58wwmp 3391 27 in in IN cord-015306-us58wwmp 3391 28 CKD CKD NNP cord-015306-us58wwmp 3391 29 patients patient NNS cord-015306-us58wwmp 3391 30 . . . cord-015306-us58wwmp 3392 1 Objective objective NN cord-015306-us58wwmp 3392 2 : : : cord-015306-us58wwmp 3393 1 Concerns concern NNS cord-015306-us58wwmp 3393 2 have have VBP cord-015306-us58wwmp 3393 3 been be VBN cord-015306-us58wwmp 3393 4 raised raise VBN cord-015306-us58wwmp 3393 5 about about IN cord-015306-us58wwmp 3393 6 possible possible JJ cord-015306-us58wwmp 3393 7 adverse adverse JJ cord-015306-us58wwmp 3393 8 effects effect NNS cord-015306-us58wwmp 3393 9 of of IN cord-015306-us58wwmp 3393 10 growth growth NN cord-015306-us58wwmp 3393 11 hormone(GH hormone(gh ADD cord-015306-us58wwmp 3393 12 ) ) -RRB- cord-015306-us58wwmp 3393 13 in in IN cord-015306-us58wwmp 3393 14 short short JJ cord-015306-us58wwmp 3393 15 children child NNS cord-015306-us58wwmp 3393 16 with with IN cord-015306-us58wwmp 3393 17 chronic chronic JJ cord-015306-us58wwmp 3393 18 renal renal JJ cord-015306-us58wwmp 3393 19 diseases disease NNS cord-015306-us58wwmp 3393 20 . . . cord-015306-us58wwmp 3394 1 Six six CD cord-015306-us58wwmp 3394 2 cases case NNS cord-015306-us58wwmp 3394 3 of of IN cord-015306-us58wwmp 3394 4 short short JJ cord-015306-us58wwmp 3394 5 children child NNS cord-015306-us58wwmp 3394 6 with with IN cord-015306-us58wwmp 3394 7 chronic chronic JJ cord-015306-us58wwmp 3394 8 renal renal JJ cord-015306-us58wwmp 3394 9 diseases disease NNS cord-015306-us58wwmp 3395 1 CKD CKD NNP cord-015306-us58wwmp 3395 2 were be VBD cord-015306-us58wwmp 3395 3 studied study VBN cord-015306-us58wwmp 3395 4 in in IN cord-015306-us58wwmp 3395 5 our -PRON- PRP$ cord-015306-us58wwmp 3395 6 hospital hospital NN cord-015306-us58wwmp 3395 7 , , , cord-015306-us58wwmp 3395 8 the the DT cord-015306-us58wwmp 3395 9 microalbuminuria microalbuminuria NNP cord-015306-us58wwmp 3395 10 as as IN cord-015306-us58wwmp 3395 11 a a DT cord-015306-us58wwmp 3395 12 sensitive sensitive JJ cord-015306-us58wwmp 3395 13 parameter parameter NN cord-015306-us58wwmp 3395 14 of of IN cord-015306-us58wwmp 3395 15 early early JJ cord-015306-us58wwmp 3395 16 glomerular glomerular JJ cord-015306-us58wwmp 3395 17 damage damage NN cord-015306-us58wwmp 3395 18 was be VBD cord-015306-us58wwmp 3395 19 detected detect VBN cord-015306-us58wwmp 3395 20 during during IN cord-015306-us58wwmp 3395 21 the the DT cord-015306-us58wwmp 3395 22 treatment treatment NN cord-015306-us58wwmp 3395 23 of of IN cord-015306-us58wwmp 3395 24 recombinant recombinant JJ cord-015306-us58wwmp 3395 25 human human JJ cord-015306-us58wwmp 3395 26 growth growth NN cord-015306-us58wwmp 3395 27 hormone hormone NN cord-015306-us58wwmp 3395 28 . . . cord-015306-us58wwmp 3396 1 The the DT cord-015306-us58wwmp 3396 2 individual individual JJ cord-015306-us58wwmp 3396 3 growth growth NN cord-015306-us58wwmp 3396 4 response response NN cord-015306-us58wwmp 3396 5 to to IN cord-015306-us58wwmp 3396 6 GH GH NNP cord-015306-us58wwmp 3396 7 was be VBD cord-015306-us58wwmp 3396 8 also also RB cord-015306-us58wwmp 3396 9 observed observe VBN cord-015306-us58wwmp 3396 10 . . . cord-015306-us58wwmp 3397 1 Methods method NNS cord-015306-us58wwmp 3397 2 : : : cord-015306-us58wwmp 3397 3 Of of IN cord-015306-us58wwmp 3397 4 the the DT cord-015306-us58wwmp 3397 5 6 6 CD cord-015306-us58wwmp 3397 6 cases case NNS cord-015306-us58wwmp 3397 7 , , , cord-015306-us58wwmp 3397 8 male male NN cord-015306-us58wwmp 3397 9 were be VBD cord-015306-us58wwmp 3397 10 4 4 CD cord-015306-us58wwmp 3397 11 , , , cord-015306-us58wwmp 3397 12 female female JJ cord-015306-us58wwmp 3397 13 2 2 CD cord-015306-us58wwmp 3397 14 , , , cord-015306-us58wwmp 3397 15 the the DT cord-015306-us58wwmp 3397 16 onset onset NN cord-015306-us58wwmp 3397 17 age age NN cord-015306-us58wwmp 3397 18 ranged range VBD cord-015306-us58wwmp 3397 19 from from IN cord-015306-us58wwmp 3397 20 4 4 CD cord-015306-us58wwmp 3397 21 to to TO cord-015306-us58wwmp 3397 22 14 14 CD cord-015306-us58wwmp 3397 23 years year NNS cord-015306-us58wwmp 3397 24 old old JJ cord-015306-us58wwmp 3397 25 , , , cord-015306-us58wwmp 3397 26 all all DT cord-015306-us58wwmp 3397 27 were be VBD cord-015306-us58wwmp 3397 28 diagnosed diagnose VBN cord-015306-us58wwmp 3397 29 as as IN cord-015306-us58wwmp 3397 30 growth growth NN cord-015306-us58wwmp 3397 31 retarded retarded JJ cord-015306-us58wwmp 3397 32 children child NNS cord-015306-us58wwmp 3397 33 with with IN cord-015306-us58wwmp 3397 34 various various JJ cord-015306-us58wwmp 3397 35 chronic chronic JJ cord-015306-us58wwmp 3397 36 renal renal JJ cord-015306-us58wwmp 3397 37 diseases disease NNS cord-015306-us58wwmp 3397 38 . . . cord-015306-us58wwmp 3398 1 The the DT cord-015306-us58wwmp 3398 2 dosage dosage NN cord-015306-us58wwmp 3398 3 of of IN cord-015306-us58wwmp 3398 4 GH GH NNP cord-015306-us58wwmp 3398 5 was be VBD cord-015306-us58wwmp 3398 6 0.1 0.1 CD cord-015306-us58wwmp 3398 7 IU IU NNP cord-015306-us58wwmp 3398 8 / / SYM cord-015306-us58wwmp 3398 9 kg kg NN cord-015306-us58wwmp 3398 10 / / SYM cord-015306-us58wwmp 3398 11 d d NN cord-015306-us58wwmp 3398 12 . . . cord-015306-us58wwmp 3399 1 The the DT cord-015306-us58wwmp 3399 2 follow follow NN cord-015306-us58wwmp 3399 3 - - HYPH cord-015306-us58wwmp 3399 4 up up NN cord-015306-us58wwmp 3399 5 period period NN cord-015306-us58wwmp 3399 6 was be VBD cord-015306-us58wwmp 3399 7 from from IN cord-015306-us58wwmp 3399 8 3 3 CD cord-015306-us58wwmp 3399 9 months month NNS cord-015306-us58wwmp 3399 10 to to IN cord-015306-us58wwmp 3399 11 1years 1years CD cord-015306-us58wwmp 3399 12 . . . cord-015306-us58wwmp 3400 1 Microalbuminuria Microalbuminuria NNP cord-015306-us58wwmp 3400 2 was be VBD cord-015306-us58wwmp 3400 3 measured measure VBN cord-015306-us58wwmp 3400 4 by by IN cord-015306-us58wwmp 3400 5 a a DT cord-015306-us58wwmp 3400 6 commercially commercially RB cord-015306-us58wwmp 3400 7 available available JJ cord-015306-us58wwmp 3400 8 ELISA ELISA NNP cord-015306-us58wwmp 3400 9 kit kit NN cord-015306-us58wwmp 3400 10 , , , cord-015306-us58wwmp 3400 11 as as IN cord-015306-us58wwmp 3400 12 a a DT cord-015306-us58wwmp 3400 13 sensitive sensitive JJ cord-015306-us58wwmp 3400 14 parameter parameter NN cord-015306-us58wwmp 3400 15 of of IN cord-015306-us58wwmp 3400 16 early early JJ cord-015306-us58wwmp 3400 17 glomerular glomerular JJ cord-015306-us58wwmp 3400 18 damage damage NN cord-015306-us58wwmp 3400 19 in in IN cord-015306-us58wwmp 3400 20 children child NNS cord-015306-us58wwmp 3400 21 being be VBG cord-015306-us58wwmp 3400 22 treated treat VBN cord-015306-us58wwmp 3400 23 with with IN cord-015306-us58wwmp 3400 24 recombinant recombinant JJ cord-015306-us58wwmp 3400 25 human human JJ cord-015306-us58wwmp 3400 26 growth growth NN cord-015306-us58wwmp 3400 27 hormone hormone NN cord-015306-us58wwmp 3400 28 . . . cord-015306-us58wwmp 3401 1 Serum serum NN cord-015306-us58wwmp 3401 2 insulin insulin NN cord-015306-us58wwmp 3401 3 - - HYPH cord-015306-us58wwmp 3401 4 like like JJ cord-015306-us58wwmp 3401 5 growth growth NN cord-015306-us58wwmp 3401 6 factor factor NN cord-015306-us58wwmp 3401 7 IGF- IGF- VBN cord-015306-us58wwmp 3402 1 I -PRON- PRP cord-015306-us58wwmp 3402 2 concentration concentration NN cord-015306-us58wwmp 3402 3 and and CC cord-015306-us58wwmp 3402 4 IGFBP3 IGFBP3 NNP cord-015306-us58wwmp 3402 5 were be VBD cord-015306-us58wwmp 3402 6 also also RB cord-015306-us58wwmp 3402 7 measured measure VBN cord-015306-us58wwmp 3402 8 before before RB cord-015306-us58wwmp 3402 9 and and CC cord-015306-us58wwmp 3402 10 during during IN cord-015306-us58wwmp 3402 11 the the DT cord-015306-us58wwmp 3402 12 treatment treatment NN cord-015306-us58wwmp 3402 13 with with IN cord-015306-us58wwmp 3402 14 GH GH NNP cord-015306-us58wwmp 3402 15 . . . cord-015306-us58wwmp 3403 1 Results result NNS cord-015306-us58wwmp 3403 2 : : : cord-015306-us58wwmp 3404 1 There there EX cord-015306-us58wwmp 3404 2 was be VBD cord-015306-us58wwmp 3404 3 no no DT cord-015306-us58wwmp 3404 4 statistically statistically RB cord-015306-us58wwmp 3404 5 difference difference NN cord-015306-us58wwmp 3404 6 on on IN cord-015306-us58wwmp 3404 7 the the DT cord-015306-us58wwmp 3404 8 level level NN cord-015306-us58wwmp 3404 9 of of IN cord-015306-us58wwmp 3404 10 microalbuminuria microalbuminuria FW cord-015306-us58wwmp 3404 11 compared compare VBN cord-015306-us58wwmp 3404 12 with with IN cord-015306-us58wwmp 3404 13 that that DT cord-015306-us58wwmp 3404 14 of of IN cord-015306-us58wwmp 3404 15 pretreatment pretreatment NN cord-015306-us58wwmp 3404 16 . . . cord-015306-us58wwmp 3405 1 Linear linear JJ cord-015306-us58wwmp 3405 2 growth growth NN cord-015306-us58wwmp 3405 3 were be VBD cord-015306-us58wwmp 3405 4 1.0 1.0 CD cord-015306-us58wwmp 3405 5 cm cm NNS cord-015306-us58wwmp 3405 6 / / SYM cord-015306-us58wwmp 3405 7 month month NN cord-015306-us58wwmp 3405 8 with with IN cord-015306-us58wwmp 3405 9 an an DT cord-015306-us58wwmp 3405 10 increment increment NN cord-015306-us58wwmp 3405 11 in in IN cord-015306-us58wwmp 3405 12 height height NN cord-015306-us58wwmp 3405 13 SDS SDS NNP cord-015306-us58wwmp 3405 14 by by IN cord-015306-us58wwmp 3405 15 1.5 1.5 CD cord-015306-us58wwmp 3405 16 at at IN cord-015306-us58wwmp 3405 17 the the DT cord-015306-us58wwmp 3405 18 end end NN cord-015306-us58wwmp 3405 19 of of IN cord-015306-us58wwmp 3405 20 the the DT cord-015306-us58wwmp 3405 21 first first JJ cord-015306-us58wwmp 3405 22 year year NN cord-015306-us58wwmp 3405 23 of of IN cord-015306-us58wwmp 3405 24 GH GH NNP cord-015306-us58wwmp 3405 25 treatment treatment NN cord-015306-us58wwmp 3405 26 . . . cord-015306-us58wwmp 3406 1 Growth growth NN cord-015306-us58wwmp 3406 2 retardation retardation NN cord-015306-us58wwmp 3406 3 in in IN cord-015306-us58wwmp 3406 4 children child NNS cord-015306-us58wwmp 3406 5 with with IN cord-015306-us58wwmp 3406 6 CKD CKD NNP cord-015306-us58wwmp 3406 7 is be VBZ cord-015306-us58wwmp 3406 8 associated associate VBN cord-015306-us58wwmp 3406 9 with with IN cord-015306-us58wwmp 3406 10 normal normal JJ cord-015306-us58wwmp 3406 11 to to IN cord-015306-us58wwmp 3406 12 slightly slightly RB cord-015306-us58wwmp 3406 13 low low JJ cord-015306-us58wwmp 3406 14 concentrations concentration NNS cord-015306-us58wwmp 3406 15 of of IN cord-015306-us58wwmp 3406 16 ( ( -LRB- cord-015306-us58wwmp 3406 17 IGF)-I igf)-i NN cord-015306-us58wwmp 3406 18 and and CC cord-015306-us58wwmp 3406 19 IGFBP3 IGFBP3 NNP cord-015306-us58wwmp 3406 20 . . . cord-015306-us58wwmp 3407 1 Objective objective NN cord-015306-us58wwmp 3407 2 : : : cord-015306-us58wwmp 3408 1 Iron iron NN cord-015306-us58wwmp 3408 2 deficiency deficiency NN cord-015306-us58wwmp 3408 3 anaemia anaemia NN cord-015306-us58wwmp 3408 4 is be VBZ cord-015306-us58wwmp 3408 5 common common JJ cord-015306-us58wwmp 3408 6 in in IN cord-015306-us58wwmp 3408 7 chronic chronic JJ cord-015306-us58wwmp 3408 8 haemodialysis haemodialysis NN cord-015306-us58wwmp 3408 9 patients patient NNS cord-015306-us58wwmp 3408 10 and and CC cord-015306-us58wwmp 3408 11 is be VBZ cord-015306-us58wwmp 3408 12 the the DT cord-015306-us58wwmp 3408 13 most most RBS cord-015306-us58wwmp 3408 14 common common JJ cord-015306-us58wwmp 3408 15 factor factor NN cord-015306-us58wwmp 3408 16 of of IN cord-015306-us58wwmp 3408 17 resistance resistance NN cord-015306-us58wwmp 3408 18 to to IN cord-015306-us58wwmp 3408 19 erythropoeitin erythropoeitin NN cord-015306-us58wwmp 3408 20 treatment treatment NN cord-015306-us58wwmp 3408 21 . . . cord-015306-us58wwmp 3409 1 KDOQI KDOQI NNP cord-015306-us58wwmp 3409 2 Clinical Clinical NNP cord-015306-us58wwmp 3409 3 Practice Practice NNP cord-015306-us58wwmp 3409 4 Guidelines Guidelines NNPS cord-015306-us58wwmp 3409 5 and and CC cord-015306-us58wwmp 3409 6 Recommendations Recommendations NNPS cord-015306-us58wwmp 3409 7 for for IN cord-015306-us58wwmp 3409 8 Anaemia anaemia NN cord-015306-us58wwmp 3409 9 in in IN cord-015306-us58wwmp 3409 10 CKD CKD NNP cord-015306-us58wwmp 3409 11 suggest suggest VBP cord-015306-us58wwmp 3409 12 maintaining maintain VBG cord-015306-us58wwmp 3409 13 Hb Hb NNP cord-015306-us58wwmp 3409 14 levels level NNS cord-015306-us58wwmp 3409 15 between between IN cord-015306-us58wwmp 3409 16 11 11 CD cord-015306-us58wwmp 3409 17 - - SYM cord-015306-us58wwmp 3409 18 12 12 CD cord-015306-us58wwmp 3409 19 g g NN cord-015306-us58wwmp 3409 20 / / SYM cord-015306-us58wwmp 3409 21 dL dl NN cord-015306-us58wwmp 3409 22 , , , cord-015306-us58wwmp 3409 23 TSATS TSATS NNP cord-015306-us58wwmp 3409 24 > > XX cord-015306-us58wwmp 3409 25 20 20 CD cord-015306-us58wwmp 3409 26 % % NN cord-015306-us58wwmp 3409 27 and and CC cord-015306-us58wwmp 3409 28 serum serum NN cord-015306-us58wwmp 3409 29 ferritin ferritin NNS cord-015306-us58wwmp 3409 30 above above IN cord-015306-us58wwmp 3409 31 100 100 CD cord-015306-us58wwmp 3409 32 ng ng NN cord-015306-us58wwmp 3409 33 / / SYM cord-015306-us58wwmp 3409 34 ml ml NN cord-015306-us58wwmp 3409 35 . . . cord-015306-us58wwmp 3410 1 Our -PRON- PRP$ cord-015306-us58wwmp 3410 2 unit unit NN cord-015306-us58wwmp 3410 3 's 's POS cord-015306-us58wwmp 3410 4 previous previous JJ cord-015306-us58wwmp 3410 5 practice practice NN cord-015306-us58wwmp 3410 6 provided provide VBN cord-015306-us58wwmp 3410 7 1 1 CD cord-015306-us58wwmp 3410 8 - - SYM cord-015306-us58wwmp 3410 9 2 2 CD cord-015306-us58wwmp 3410 10 mg mg NNP cord-015306-us58wwmp 3410 11 / / SYM cord-015306-us58wwmp 3410 12 kg kg NNP cord-015306-us58wwmp 3410 13 / / SYM cord-015306-us58wwmp 3410 14 week week NN cord-015306-us58wwmp 3410 15 of of IN cord-015306-us58wwmp 3410 16 elemental elemental JJ cord-015306-us58wwmp 3410 17 iron iron NN cord-015306-us58wwmp 3410 18 intravenously intravenously RB cord-015306-us58wwmp 3410 19 to to IN cord-015306-us58wwmp 3410 20 our -PRON- PRP$ cord-015306-us58wwmp 3410 21 haemodialysis haemodialysis NN cord-015306-us58wwmp 3410 22 population population NN cord-015306-us58wwmp 3410 23 and and CC cord-015306-us58wwmp 3410 24 monitored monitor VBD cord-015306-us58wwmp 3410 25 blood blood NN cord-015306-us58wwmp 3410 26 parameters parameter NNS cord-015306-us58wwmp 3410 27 monthly monthly RB cord-015306-us58wwmp 3410 28 . . . cord-015306-us58wwmp 3411 1 From from IN cord-015306-us58wwmp 3411 2 July July NNP cord-015306-us58wwmp 3411 3 2012 2012 CD cord-015306-us58wwmp 3411 4 , , , cord-015306-us58wwmp 3411 5 we -PRON- PRP cord-015306-us58wwmp 3411 6 changed change VBD cord-015306-us58wwmp 3411 7 our -PRON- PRP$ cord-015306-us58wwmp 3411 8 practice practice NN cord-015306-us58wwmp 3411 9 to to TO cord-015306-us58wwmp 3411 10 withhold withhold VB cord-015306-us58wwmp 3411 11 routine routine JJ cord-015306-us58wwmp 3411 12 administration administration NN cord-015306-us58wwmp 3411 13 of of IN cord-015306-us58wwmp 3411 14 IV IV NNP cord-015306-us58wwmp 3411 15 iron iron NN cord-015306-us58wwmp 3411 16 , , , cord-015306-us58wwmp 3411 17 unless unless IN cord-015306-us58wwmp 3411 18 blood blood NN cord-015306-us58wwmp 3411 19 parameters parameter NNS cord-015306-us58wwmp 3411 20 ( ( -LRB- cord-015306-us58wwmp 3411 21 monitored monitor VBN cord-015306-us58wwmp 3411 22 fortnightly fortnightly RB cord-015306-us58wwmp 3411 23 ) ) -RRB- cord-015306-us58wwmp 3411 24 suggested suggest VBN cord-015306-us58wwmp 3411 25 iron iron NN cord-015306-us58wwmp 3411 26 deficiency deficiency NN cord-015306-us58wwmp 3411 27 . . . cord-015306-us58wwmp 3412 1 We -PRON- PRP cord-015306-us58wwmp 3412 2 assessed assess VBD cord-015306-us58wwmp 3412 3 the the DT cord-015306-us58wwmp 3412 4 change change NN cord-015306-us58wwmp 3412 5 in in IN cord-015306-us58wwmp 3412 6 our -PRON- PRP$ cord-015306-us58wwmp 3412 7 practice practice NN cord-015306-us58wwmp 3412 8 in in IN cord-015306-us58wwmp 3412 9 safely safely RB cord-015306-us58wwmp 3412 10 reducing reduce VBG cord-015306-us58wwmp 3412 11 the the DT cord-015306-us58wwmp 3412 12 frequency frequency NN cord-015306-us58wwmp 3412 13 of of IN cord-015306-us58wwmp 3412 14 IV IV NNP cord-015306-us58wwmp 3412 15 iron iron NNP cord-015306-us58wwmp 3412 16 administration administration NN cord-015306-us58wwmp 3412 17 in in IN cord-015306-us58wwmp 3412 18 our -PRON- PRP$ cord-015306-us58wwmp 3412 19 haemodialysis haemodialysis NN cord-015306-us58wwmp 3412 20 population population NN cord-015306-us58wwmp 3412 21 . . . cord-015306-us58wwmp 3413 1 Methods method NNS cord-015306-us58wwmp 3413 2 : : : cord-015306-us58wwmp 3413 3 We -PRON- PRP cord-015306-us58wwmp 3413 4 included include VBD cord-015306-us58wwmp 3413 5 all all DT cord-015306-us58wwmp 3413 6 9 9 CD cord-015306-us58wwmp 3413 7 children child NNS cord-015306-us58wwmp 3413 8 attending attend VBG cord-015306-us58wwmp 3413 9 our -PRON- PRP$ cord-015306-us58wwmp 3413 10 haemodialysis haemodialysis NNP cord-015306-us58wwmp 3413 11 unit unit NN cord-015306-us58wwmp 3413 12 ( ( -LRB- cord-015306-us58wwmp 3413 13 July July NNP cord-015306-us58wwmp 3413 14 2012 2012 CD cord-015306-us58wwmp 3413 15 ) ) -RRB- cord-015306-us58wwmp 3413 16 . . . cord-015306-us58wwmp 3414 1 We -PRON- PRP cord-015306-us58wwmp 3414 2 used use VBD cord-015306-us58wwmp 3414 3 % % NN cord-015306-us58wwmp 3414 4 hypochromia hypochromia NN cord-015306-us58wwmp 3414 5 of of IN cord-015306-us58wwmp 3414 6 > > $ cord-015306-us58wwmp 3414 7 4 4 CD cord-015306-us58wwmp 3414 8 % % NN cord-015306-us58wwmp 3414 9 , , , cord-015306-us58wwmp 3414 10 correlating correlate VBG cord-015306-us58wwmp 3414 11 with with IN cord-015306-us58wwmp 3414 12 Hb Hb NNP cord-015306-us58wwmp 3414 13 level level NN cord-015306-us58wwmp 3414 14 of of IN cord-015306-us58wwmp 3414 15 < < $ cord-015306-us58wwmp 3414 16 11 11 CD cord-015306-us58wwmp 3414 17 g g NN cord-015306-us58wwmp 3414 18 / / SYM cord-015306-us58wwmp 3414 19 dL dl NN cord-015306-us58wwmp 3414 20 as as IN cord-015306-us58wwmp 3414 21 a a DT cord-015306-us58wwmp 3414 22 marker marker NN cord-015306-us58wwmp 3414 23 for for IN cord-015306-us58wwmp 3414 24 initiating initiate VBG cord-015306-us58wwmp 3414 25 IV IV NNP cord-015306-us58wwmp 3414 26 iron iron NN cord-015306-us58wwmp 3414 27 sucrose sucrose NN cord-015306-us58wwmp 3414 28 ( ( -LRB- cord-015306-us58wwmp 3414 29 3mg 3mg NNP cord-015306-us58wwmp 3414 30 / / SYM cord-015306-us58wwmp 3414 31 kg kg NN cord-015306-us58wwmp 3414 32 / / SYM cord-015306-us58wwmp 3414 33 week week NN cord-015306-us58wwmp 3414 34 ) ) -RRB- cord-015306-us58wwmp 3414 35 until until IN cord-015306-us58wwmp 3414 36 improvement improvement NN cord-015306-us58wwmp 3414 37 of of IN cord-015306-us58wwmp 3414 38 the the DT cord-015306-us58wwmp 3414 39 above above JJ cord-015306-us58wwmp 3414 40 parameters parameter NNS cord-015306-us58wwmp 3414 41 . . . cord-015306-us58wwmp 3415 1 Serum serum NN cord-015306-us58wwmp 3415 2 Hb Hb NNP cord-015306-us58wwmp 3415 3 and and CC cord-015306-us58wwmp 3415 4 % % NN cord-015306-us58wwmp 3415 5 hypochromia hypochromia NN cord-015306-us58wwmp 3415 6 were be VBD cord-015306-us58wwmp 3415 7 monitored monitor VBN cord-015306-us58wwmp 3415 8 at at IN cord-015306-us58wwmp 3415 9 the the DT cord-015306-us58wwmp 3415 10 start start NN cord-015306-us58wwmp 3415 11 of of IN cord-015306-us58wwmp 3415 12 change change NN cord-015306-us58wwmp 3415 13 - - HYPH cord-015306-us58wwmp 3415 14 over over NN cord-015306-us58wwmp 3415 15 and and CC cord-015306-us58wwmp 3415 16 fortnightly fortnightly RB cord-015306-us58wwmp 3415 17 thereafter thereafter RB cord-015306-us58wwmp 3415 18 . . . cord-015306-us58wwmp 3416 1 All all DT cord-015306-us58wwmp 3416 2 patients patient NNS cord-015306-us58wwmp 3416 3 received receive VBD cord-015306-us58wwmp 3416 4 routine routine JJ cord-015306-us58wwmp 3416 5 erythropoietin erythropoietin NN cord-015306-us58wwmp 3416 6 at at IN cord-015306-us58wwmp 3416 7 recommended recommend VBN cord-015306-us58wwmp 3416 8 doses dose NNS cord-015306-us58wwmp 3416 9 of of IN cord-015306-us58wwmp 3416 10 between between IN cord-015306-us58wwmp 3416 11 50 50 CD cord-015306-us58wwmp 3416 12 - - SYM cord-015306-us58wwmp 3416 13 300 300 CD cord-015306-us58wwmp 3416 14 units unit NNS cord-015306-us58wwmp 3416 15 / / SYM cord-015306-us58wwmp 3416 16 kg kg NN cord-015306-us58wwmp 3416 17 / / SYM cord-015306-us58wwmp 3416 18 week week NN cord-015306-us58wwmp 3416 19 . . . cord-015306-us58wwmp 3417 1 Results result NNS cord-015306-us58wwmp 3417 2 : : : cord-015306-us58wwmp 3418 1 At at IN cord-015306-us58wwmp 3418 2 initiation initiation NN cord-015306-us58wwmp 3418 3 of of IN cord-015306-us58wwmp 3418 4 change change NN cord-015306-us58wwmp 3418 5 - - HYPH cord-015306-us58wwmp 3418 6 over over RP cord-015306-us58wwmp 3418 7 , , , cord-015306-us58wwmp 3418 8 there there EX cord-015306-us58wwmp 3418 9 were be VBD cord-015306-us58wwmp 3418 10 9 9 CD cord-015306-us58wwmp 3418 11 patients patient NNS cord-015306-us58wwmp 3418 12 with with IN cord-015306-us58wwmp 3418 13 mean mean NN cord-015306-us58wwmp 3419 1 Hb Hb NNP cord-015306-us58wwmp 3419 2 11.3 11.3 CD cord-015306-us58wwmp 3419 3 g g NNP cord-015306-us58wwmp 3419 4 / / SYM cord-015306-us58wwmp 3419 5 dL dl NN cord-015306-us58wwmp 3419 6 , , , cord-015306-us58wwmp 3420 1 mean mean VB cord-015306-us58wwmp 3420 2 % % NN cord-015306-us58wwmp 3420 3 hypochromia hypochromia NNP cord-015306-us58wwmp 3420 4 1.2 1.2 CD cord-015306-us58wwmp 3420 5 % % NN cord-015306-us58wwmp 3420 6 and and CC cord-015306-us58wwmp 3420 7 mean mean VB cord-015306-us58wwmp 3420 8 TSATS TSATS NNP cord-015306-us58wwmp 3420 9 27.7 27.7 CD cord-015306-us58wwmp 3420 10 % % NN cord-015306-us58wwmp 3420 11 . . . cord-015306-us58wwmp 3421 1 From from IN cord-015306-us58wwmp 3421 2 July July NNP cord-015306-us58wwmp 3421 3 2012 2012 CD cord-015306-us58wwmp 3421 4 -Mar -Mar VBZ cord-015306-us58wwmp 3421 5 2013 2013 CD cord-015306-us58wwmp 3421 6 , , , cord-015306-us58wwmp 3421 7 four four CD cord-015306-us58wwmp 3421 8 patients patient NNS cord-015306-us58wwmp 3421 9 required require VBD cord-015306-us58wwmp 3421 10 IV IV NNP cord-015306-us58wwmp 3421 11 iron iron NN cord-015306-us58wwmp 3421 12 therapy therapy NN cord-015306-us58wwmp 3421 13 ( ( -LRB- cord-015306-us58wwmp 3421 14 mean mean VB cord-015306-us58wwmp 3421 15 Hb Hb NNP cord-015306-us58wwmp 3421 16 9.2 9.2 CD cord-015306-us58wwmp 3421 17 g g NN cord-015306-us58wwmp 3421 18 / / SYM cord-015306-us58wwmp 3421 19 dL dl NN cord-015306-us58wwmp 3421 20 , , , cord-015306-us58wwmp 3421 21 mean mean VBP cord-015306-us58wwmp 3421 22 % % NN cord-015306-us58wwmp 3421 23 hypochromia hypochromia NN cord-015306-us58wwmp 3421 24 6.2 6.2 CD cord-015306-us58wwmp 3421 25 % % NN cord-015306-us58wwmp 3421 26 , , , cord-015306-us58wwmp 3422 1 mean mean VB cord-015306-us58wwmp 3422 2 TSATS TSATS NNP cord-015306-us58wwmp 3422 3 16.3 16.3 CD cord-015306-us58wwmp 3422 4 % % NN cord-015306-us58wwmp 3422 5 ) ) -RRB- cord-015306-us58wwmp 3422 6 . . . cord-015306-us58wwmp 3423 1 Three three CD cord-015306-us58wwmp 3423 2 patients patient NNS cord-015306-us58wwmp 3423 3 had have VBD cord-015306-us58wwmp 3423 4 4 4 CD cord-015306-us58wwmp 3423 5 weeks week NNS cord-015306-us58wwmp 3423 6 and and CC cord-015306-us58wwmp 3423 7 one one CD cord-015306-us58wwmp 3423 8 patient patient NN cord-015306-us58wwmp 3423 9 had have VBD cord-015306-us58wwmp 3423 10 7 7 CD cord-015306-us58wwmp 3423 11 weeks week NNS cord-015306-us58wwmp 3423 12 of of IN cord-015306-us58wwmp 3423 13 IV IV NNP cord-015306-us58wwmp 3423 14 iron iron NN cord-015306-us58wwmp 3424 1 sucrose sucrose NN cord-015306-us58wwmp 3424 2 3 3 CD cord-015306-us58wwmp 3424 3 mg mg NNP cord-015306-us58wwmp 3424 4 / / SYM cord-015306-us58wwmp 3424 5 kg kg NNP cord-015306-us58wwmp 3424 6 / / SYM cord-015306-us58wwmp 3424 7 week week NN cord-015306-us58wwmp 3424 8 to to TO cord-015306-us58wwmp 3424 9 achieve achieve VB cord-015306-us58wwmp 3424 10 normalisation normalisation NN cord-015306-us58wwmp 3424 11 of of IN cord-015306-us58wwmp 3424 12 serum serum NN cord-015306-us58wwmp 3424 13 Hb Hb NNP cord-015306-us58wwmp 3424 14 ( ( -LRB- cord-015306-us58wwmp 3424 15 mean mean VBP cord-015306-us58wwmp 3424 16 11.5 11.5 CD cord-015306-us58wwmp 3424 17 g g NN cord-015306-us58wwmp 3424 18 / / SYM cord-015306-us58wwmp 3424 19 dL dl NN cord-015306-us58wwmp 3424 20 ) ) -RRB- cord-015306-us58wwmp 3424 21 , , , cord-015306-us58wwmp 3424 22 % % NN cord-015306-us58wwmp 3424 23 hypochromia hypochromia NN cord-015306-us58wwmp 3424 24 ( ( -LRB- cord-015306-us58wwmp 3424 25 mean mean VB cord-015306-us58wwmp 3424 26 2.73 2.73 CD cord-015306-us58wwmp 3424 27 % % NN cord-015306-us58wwmp 3424 28 ) ) -RRB- cord-015306-us58wwmp 3424 29 and and CC cord-015306-us58wwmp 3424 30 TSATS TSATS NNP cord-015306-us58wwmp 3424 31 ( ( -LRB- cord-015306-us58wwmp 3425 1 mean mean VB cord-015306-us58wwmp 3425 2 26 26 CD cord-015306-us58wwmp 3425 3 % % NN cord-015306-us58wwmp 3425 4 ) ) -RRB- cord-015306-us58wwmp 3425 5 . . . cord-015306-us58wwmp 3426 1 At at IN cord-015306-us58wwmp 3426 2 time time NN cord-015306-us58wwmp 3426 3 of of IN cord-015306-us58wwmp 3426 4 reporting reporting NN cord-015306-us58wwmp 3426 5 ( ( -LRB- cord-015306-us58wwmp 3426 6 Mar Mar NNP cord-015306-us58wwmp 3426 7 2013 2013 CD cord-015306-us58wwmp 3426 8 ) ) -RRB- cord-015306-us58wwmp 3426 9 , , , cord-015306-us58wwmp 3426 10 there there EX cord-015306-us58wwmp 3426 11 were be VBD cord-015306-us58wwmp 3426 12 7 7 CD cord-015306-us58wwmp 3426 13 patients patient NNS cord-015306-us58wwmp 3426 14 with with IN cord-015306-us58wwmp 3426 15 mean mean JJ cord-015306-us58wwmp 3426 16 Hb Hb NNP cord-015306-us58wwmp 3426 17 11.22 11.22 CD cord-015306-us58wwmp 3426 18 g g NNP cord-015306-us58wwmp 3426 19 / / SYM cord-015306-us58wwmp 3426 20 dL dl NN cord-015306-us58wwmp 3426 21 , , , cord-015306-us58wwmp 3426 22 mean mean VBP cord-015306-us58wwmp 3426 23 % % NN cord-015306-us58wwmp 3426 24 hypochromia hypochromia NN cord-015306-us58wwmp 3426 25 2.07 2.07 CD cord-015306-us58wwmp 3426 26 % % NN cord-015306-us58wwmp 3426 27 and and CC cord-015306-us58wwmp 3426 28 mean mean VB cord-015306-us58wwmp 3426 29 TSATS TSATS NNP cord-015306-us58wwmp 3426 30 28.2 28.2 CD cord-015306-us58wwmp 3426 31 % % NN cord-015306-us58wwmp 3426 32 . . . cord-015306-us58wwmp 3427 1 Two two CD cord-015306-us58wwmp 3427 2 patients patient NNS cord-015306-us58wwmp 3427 3 received receive VBD cord-015306-us58wwmp 3427 4 transplants transplant NNS cord-015306-us58wwmp 3427 5 . . . cord-015306-us58wwmp 3428 1 Conclusion conclusion NN cord-015306-us58wwmp 3428 2 : : : cord-015306-us58wwmp 3428 3 A a DT cord-015306-us58wwmp 3428 4 novel novel JJ cord-015306-us58wwmp 3428 5 change change NN cord-015306-us58wwmp 3428 6 in in IN cord-015306-us58wwmp 3428 7 our -PRON- PRP$ cord-015306-us58wwmp 3428 8 practice practice NN cord-015306-us58wwmp 3428 9 has have VBZ cord-015306-us58wwmp 3428 10 resulted result VBN cord-015306-us58wwmp 3428 11 in in IN cord-015306-us58wwmp 3428 12 a a DT cord-015306-us58wwmp 3428 13 safe safe JJ cord-015306-us58wwmp 3428 14 reduction reduction NN cord-015306-us58wwmp 3428 15 of of IN cord-015306-us58wwmp 3428 16 IV IV NNP cord-015306-us58wwmp 3428 17 iron iron NN cord-015306-us58wwmp 3428 18 therapy therapy NN cord-015306-us58wwmp 3428 19 in in IN cord-015306-us58wwmp 3428 20 our -PRON- PRP$ cord-015306-us58wwmp 3428 21 population population NN cord-015306-us58wwmp 3428 22 of of IN cord-015306-us58wwmp 3428 23 children child NNS cord-015306-us58wwmp 3428 24 undergoing undergo VBG cord-015306-us58wwmp 3428 25 haemodialysis haemodialysis NNP cord-015306-us58wwmp 3428 26 . . . cord-015306-us58wwmp 3429 1 From from IN cord-015306-us58wwmp 3429 2 our -PRON- PRP$ cord-015306-us58wwmp 3429 3 findings finding NNS cord-015306-us58wwmp 3429 4 , , , cord-015306-us58wwmp 3429 5 we -PRON- PRP cord-015306-us58wwmp 3429 6 suggest suggest VBP cord-015306-us58wwmp 3429 7 avoiding avoid VBG cord-015306-us58wwmp 3429 8 routine routine JJ cord-015306-us58wwmp 3429 9 iron iron NN cord-015306-us58wwmp 3429 10 infusions infusion NNS cord-015306-us58wwmp 3429 11 in in IN cord-015306-us58wwmp 3429 12 paediatrichaemodialysis paediatrichaemodialysis NN cord-015306-us58wwmp 3429 13 , , , cord-015306-us58wwmp 3429 14 which which WDT cord-015306-us58wwmp 3429 15 is be VBZ cord-015306-us58wwmp 3429 16 unlikely unlikely JJ cord-015306-us58wwmp 3429 17 to to TO cord-015306-us58wwmp 3429 18 have have VB cord-015306-us58wwmp 3429 19 an an DT cord-015306-us58wwmp 3429 20 adverse adverse JJ cord-015306-us58wwmp 3429 21 effect effect NN cord-015306-us58wwmp 3429 22 on on IN cord-015306-us58wwmp 3429 23 the the DT cord-015306-us58wwmp 3429 24 incidence incidence NN cord-015306-us58wwmp 3429 25 of of IN cord-015306-us58wwmp 3429 26 anaemia anaemia NN cord-015306-us58wwmp 3429 27 and and CC cord-015306-us58wwmp 3429 28 will will MD cord-015306-us58wwmp 3429 29 reduce reduce VB cord-015306-us58wwmp 3429 30 the the DT cord-015306-us58wwmp 3429 31 risk risk NN cord-015306-us58wwmp 3429 32 of of IN cord-015306-us58wwmp 3429 33 inadvertent inadvertent JJ cord-015306-us58wwmp 3429 34 iron iron NN cord-015306-us58wwmp 3429 35 overload overload NN cord-015306-us58wwmp 3429 36 . . . cord-015306-us58wwmp 3430 1 Abstract abstract JJ cord-015306-us58wwmp 3430 2 # # NN cord-015306-us58wwmp 3430 3 P p NN cord-015306-us58wwmp 3430 4 - - HYPH cord-015306-us58wwmp 3430 5 SAT380 SAT380 NNP cord-015306-us58wwmp 3430 6 Reversible reversible JJ cord-015306-us58wwmp 3430 7 portal portal NN cord-015306-us58wwmp 3430 8 ascitis ascitis NN cord-015306-us58wwmp 3430 9 after after IN cord-015306-us58wwmp 3430 10 bilateral bilateral JJ cord-015306-us58wwmp 3430 11 nephrectomy nephrectomy NN cord-015306-us58wwmp 3430 12 in in IN cord-015306-us58wwmp 3430 13 infant infant NN cord-015306-us58wwmp 3430 14 with with IN cord-015306-us58wwmp 3430 15 polycystic polycystic JJ cord-015306-us58wwmp 3430 16 kidney kidney NN cord-015306-us58wwmp 3430 17 disease disease NN cord-015306-us58wwmp 3430 18 We -PRON- PRP cord-015306-us58wwmp 3430 19 report report VBP cord-015306-us58wwmp 3430 20 here here RB cord-015306-us58wwmp 3430 21 on on IN cord-015306-us58wwmp 3430 22 a a DT cord-015306-us58wwmp 3430 23 newborn newborn NN cord-015306-us58wwmp 3430 24 with with IN cord-015306-us58wwmp 3430 25 moderate moderate JJ cord-015306-us58wwmp 3430 26 renal renal JJ cord-015306-us58wwmp 3430 27 failure failure NN cord-015306-us58wwmp 3430 28 and and CC cord-015306-us58wwmp 3430 29 severe severe JJ cord-015306-us58wwmp 3430 30 hypertension hypertension NN cord-015306-us58wwmp 3430 31 due due IN cord-015306-us58wwmp 3430 32 to to IN cord-015306-us58wwmp 3430 33 autosomal autosomal JJ cord-015306-us58wwmp 3430 34 recessive recessive JJ cord-015306-us58wwmp 3430 35 polycystic polycystic JJ cord-015306-us58wwmp 3430 36 kidney kidney NN cord-015306-us58wwmp 3430 37 disease disease NN cord-015306-us58wwmp 3430 38 ( ( -LRB- cord-015306-us58wwmp 3430 39 ARPKD ARPKD NNP cord-015306-us58wwmp 3430 40 ) ) -RRB- cord-015306-us58wwmp 3430 41 . . . cord-015306-us58wwmp 3431 1 Antihypertensive antihypertensive JJ cord-015306-us58wwmp 3431 2 therapy therapy NN cord-015306-us58wwmp 3431 3 associating associate VBG cord-015306-us58wwmp 3431 4 minoxidil minoxidil NN cord-015306-us58wwmp 3431 5 , , , cord-015306-us58wwmp 3431 6 labetalol labetalol NN cord-015306-us58wwmp 3431 7 , , , cord-015306-us58wwmp 3431 8 amlodipine amlodipine NN cord-015306-us58wwmp 3431 9 and and CC cord-015306-us58wwmp 3431 10 lasilix lasilix NNP cord-015306-us58wwmp 3431 11 were be VBD cord-015306-us58wwmp 3431 12 not not RB cord-015306-us58wwmp 3431 13 able able JJ cord-015306-us58wwmp 3431 14 to to TO cord-015306-us58wwmp 3431 15 control control VB cord-015306-us58wwmp 3431 16 adequately adequately RB cord-015306-us58wwmp 3431 17 blood blood NN cord-015306-us58wwmp 3431 18 pressure pressure NN cord-015306-us58wwmp 3431 19 . . . cord-015306-us58wwmp 3432 1 Due due IN cord-015306-us58wwmp 3432 2 to to IN cord-015306-us58wwmp 3432 3 massive massive JJ cord-015306-us58wwmp 3432 4 kidney kidney NN cord-015306-us58wwmp 3432 5 enlargement enlargement NN cord-015306-us58wwmp 3432 6 , , , cord-015306-us58wwmp 3432 7 inadequate inadequate JJ cord-015306-us58wwmp 3432 8 respiratory respiratory JJ cord-015306-us58wwmp 3432 9 function function NN cord-015306-us58wwmp 3432 10 and and CC cord-015306-us58wwmp 3432 11 inability inability NN cord-015306-us58wwmp 3432 12 to to TO cord-015306-us58wwmp 3432 13 tolerate tolerate VB cord-015306-us58wwmp 3432 14 enteral enteral JJ cord-015306-us58wwmp 3432 15 nutrition nutrition NN cord-015306-us58wwmp 3432 16 , , , cord-015306-us58wwmp 3432 17 parenteral parenteral JJ cord-015306-us58wwmp 3432 18 nutrition nutrition NN cord-015306-us58wwmp 3432 19 was be VBD cord-015306-us58wwmp 3432 20 initiated initiate VBN cord-015306-us58wwmp 3432 21 at at IN cord-015306-us58wwmp 3432 22 2 2 CD cord-015306-us58wwmp 3432 23 months month NNS cord-015306-us58wwmp 3432 24 to to TO cord-015306-us58wwmp 3432 25 maintain maintain VB cord-015306-us58wwmp 3432 26 adequate adequate JJ cord-015306-us58wwmp 3432 27 calories calorie NNS cord-015306-us58wwmp 3432 28 intake intake JJ cord-015306-us58wwmp 3432 29 . . . cord-015306-us58wwmp 3433 1 At at IN cord-015306-us58wwmp 3433 2 4 4 CD cord-015306-us58wwmp 3433 3 months month NNS cord-015306-us58wwmp 3433 4 of of IN cord-015306-us58wwmp 3433 5 life life NN cord-015306-us58wwmp 3433 6 , , , cord-015306-us58wwmp 3433 7 the the DT cord-015306-us58wwmp 3433 8 infant infant NN cord-015306-us58wwmp 3433 9 presented present VBD cord-015306-us58wwmp 3433 10 severe severe JJ cord-015306-us58wwmp 3433 11 viral viral JJ cord-015306-us58wwmp 3433 12 pneumonia pneumonia NN cord-015306-us58wwmp 3433 13 complicated complicate VBN cord-015306-us58wwmp 3433 14 by by IN cord-015306-us58wwmp 3433 15 cardio cardio JJ cord-015306-us58wwmp 3433 16 respiratory respiratory JJ cord-015306-us58wwmp 3433 17 arrest arrest NN cord-015306-us58wwmp 3433 18 . . . cord-015306-us58wwmp 3434 1 He -PRON- PRP cord-015306-us58wwmp 3434 2 required require VBD cord-015306-us58wwmp 3434 3 cardio cardio JJ cord-015306-us58wwmp 3434 4 respiratory respiratory JJ cord-015306-us58wwmp 3434 5 resuscitation resuscitation NN cord-015306-us58wwmp 3434 6 and and CC cord-015306-us58wwmp 3434 7 hospitalization hospitalization NN cord-015306-us58wwmp 3434 8 in in IN cord-015306-us58wwmp 3434 9 ICU ICU NNP cord-015306-us58wwmp 3434 10 for for IN cord-015306-us58wwmp 3434 11 several several JJ cord-015306-us58wwmp 3434 12 days day NNS cord-015306-us58wwmp 3434 13 . . . cord-015306-us58wwmp 3435 1 Unilateral unilateral JJ cord-015306-us58wwmp 3435 2 right right JJ cord-015306-us58wwmp 3435 3 nephrectomy nephrectomy NN cord-015306-us58wwmp 3435 4 was be VBD cord-015306-us58wwmp 3435 5 decided decide VBN cord-015306-us58wwmp 3435 6 after after IN cord-015306-us58wwmp 3435 7 this this DT cord-015306-us58wwmp 3435 8 severe severe JJ cord-015306-us58wwmp 3435 9 complication complication NN cord-015306-us58wwmp 3435 10 in in IN cord-015306-us58wwmp 3435 11 order order NN cord-015306-us58wwmp 3435 12 to to TO cord-015306-us58wwmp 3435 13 avoid avoid VB cord-015306-us58wwmp 3435 14 similar similar JJ cord-015306-us58wwmp 3435 15 accidents accident NNS cord-015306-us58wwmp 3435 16 due due JJ cord-015306-us58wwmp 3435 17 to to IN cord-015306-us58wwmp 3435 18 massive massive JJ cord-015306-us58wwmp 3435 19 kidney kidney NN cord-015306-us58wwmp 3435 20 volume volume NN cord-015306-us58wwmp 3435 21 and and CC cord-015306-us58wwmp 3435 22 to to TO cord-015306-us58wwmp 3435 23 improve improve VB cord-015306-us58wwmp 3435 24 respiratory respiratory JJ cord-015306-us58wwmp 3435 25 and and CC cord-015306-us58wwmp 3435 26 nutrition nutrition NN cord-015306-us58wwmp 3435 27 status status NN cord-015306-us58wwmp 3435 28 . . . cord-015306-us58wwmp 3436 1 One one CD cord-015306-us58wwmp 3436 2 week week NN cord-015306-us58wwmp 3436 3 after after IN cord-015306-us58wwmp 3436 4 unilateral unilateral JJ cord-015306-us58wwmp 3436 5 nephrectomy nephrectomy NN cord-015306-us58wwmp 3436 6 , , , cord-015306-us58wwmp 3436 7 we -PRON- PRP cord-015306-us58wwmp 3436 8 noted note VBD cord-015306-us58wwmp 3436 9 rapid rapid JJ cord-015306-us58wwmp 3436 10 increase increase NN cord-015306-us58wwmp 3436 11 volume volume NN cord-015306-us58wwmp 3436 12 of of IN cord-015306-us58wwmp 3436 13 the the DT cord-015306-us58wwmp 3436 14 left left JJ cord-015306-us58wwmp 3436 15 kidney kidney NN cord-015306-us58wwmp 3436 16 and and CC cord-015306-us58wwmp 3436 17 important important JJ cord-015306-us58wwmp 3436 18 ascitis ascitis NN cord-015306-us58wwmp 3436 19 having have VBG cord-015306-us58wwmp 3436 20 the the DT cord-015306-us58wwmp 3436 21 biological biological JJ cord-015306-us58wwmp 3436 22 characteristics characteristic NNS cord-015306-us58wwmp 3436 23 of of IN cord-015306-us58wwmp 3436 24 portal portal JJ cord-015306-us58wwmp 3436 25 hypertension hypertension NN cord-015306-us58wwmp 3436 26 . . . cord-015306-us58wwmp 3437 1 Repeated repeat VBN cord-015306-us58wwmp 3437 2 aspiration aspiration NN cord-015306-us58wwmp 3437 3 of of IN cord-015306-us58wwmp 3437 4 more more JJR cord-015306-us58wwmp 3437 5 than than IN cord-015306-us58wwmp 3437 6 100 100 CD cord-015306-us58wwmp 3437 7 ml ml NNS cord-015306-us58wwmp 3437 8 of of IN cord-015306-us58wwmp 3437 9 portal portal NNP cord-015306-us58wwmp 3437 10 ascitis ascitis NNP cord-015306-us58wwmp 3437 11 was be VBD cord-015306-us58wwmp 3437 12 performed perform VBN cord-015306-us58wwmp 3437 13 every every DT cord-015306-us58wwmp 3437 14 day day NN cord-015306-us58wwmp 3437 15 . . . cord-015306-us58wwmp 3438 1 In in IN cord-015306-us58wwmp 3438 2 parallel parallel JJ cord-015306-us58wwmp 3438 3 daily daily JJ cord-015306-us58wwmp 3438 4 perfusion perfusion NN cord-015306-us58wwmp 3438 5 of of IN cord-015306-us58wwmp 3438 6 albumin albumin NN cord-015306-us58wwmp 3438 7 for for IN cord-015306-us58wwmp 3438 8 more more JJR cord-015306-us58wwmp 3438 9 than than IN cord-015306-us58wwmp 3438 10 3 3 CD cord-015306-us58wwmp 3438 11 weeks week NNS cord-015306-us58wwmp 3438 12 and and CC cord-015306-us58wwmp 3438 13 complete complete JJ cord-015306-us58wwmp 3438 14 parenteral parenteral JJ cord-015306-us58wwmp 3438 15 nutrition nutrition NN cord-015306-us58wwmp 3438 16 did do VBD cord-015306-us58wwmp 3438 17 not not RB cord-015306-us58wwmp 3438 18 succeed succeed VB cord-015306-us58wwmp 3438 19 in in IN cord-015306-us58wwmp 3438 20 treating treat VBG cord-015306-us58wwmp 3438 21 ascitis ascitis NN cord-015306-us58wwmp 3438 22 . . . cord-015306-us58wwmp 3439 1 Faced face VBN cord-015306-us58wwmp 3439 2 to to TO cord-015306-us58wwmp 3439 3 resistant resistant VB cord-015306-us58wwmp 3439 4 ascitis ascitis NN cord-015306-us58wwmp 3439 5 and and CC cord-015306-us58wwmp 3439 6 persisting persist VBG cord-015306-us58wwmp 3439 7 difficulties difficulty NNS cord-015306-us58wwmp 3439 8 in in IN cord-015306-us58wwmp 3439 9 maintaining maintain VBG cord-015306-us58wwmp 3439 10 enteral enteral JJ cord-015306-us58wwmp 3439 11 nutrition nutrition NN cord-015306-us58wwmp 3439 12 and and CC cord-015306-us58wwmp 3439 13 adequate adequate JJ cord-015306-us58wwmp 3439 14 respiratory respiratory JJ cord-015306-us58wwmp 3439 15 ventilation ventilation NN cord-015306-us58wwmp 3439 16 , , , cord-015306-us58wwmp 3439 17 left leave VBN cord-015306-us58wwmp 3439 18 nepherctomy nepherctomy NN cord-015306-us58wwmp 3439 19 was be VBD cord-015306-us58wwmp 3439 20 decided decide VBN cord-015306-us58wwmp 3439 21 and and CC cord-015306-us58wwmp 3439 22 performed perform VBN cord-015306-us58wwmp 3439 23 . . . cord-015306-us58wwmp 3440 1 Automated automate VBN cord-015306-us58wwmp 3440 2 peritoneal peritoneal JJ cord-015306-us58wwmp 3440 3 dialysis dialysis NN cord-015306-us58wwmp 3440 4 was be VBD cord-015306-us58wwmp 3440 5 rapidly rapidly RB cord-015306-us58wwmp 3440 6 initiated initiate VBN cord-015306-us58wwmp 3440 7 in in IN cord-015306-us58wwmp 3440 8 our -PRON- PRP$ cord-015306-us58wwmp 3440 9 anuric anuric JJ cord-015306-us58wwmp 3440 10 infant infant NN cord-015306-us58wwmp 3440 11 ( ( -LRB- cord-015306-us58wwmp 3440 12 weight weight NN cord-015306-us58wwmp 3440 13 after after IN cord-015306-us58wwmp 3440 14 binephrectomy4kgs binephrectomy4kgs NN cord-015306-us58wwmp 3440 15 ) ) -RRB- cord-015306-us58wwmp 3440 16 . . . cord-015306-us58wwmp 3441 1 Portal Portal NNP cord-015306-us58wwmp 3441 2 ascitis ascitis NN cord-015306-us58wwmp 3441 3 disappeared disappear VBD cord-015306-us58wwmp 3441 4 in in IN cord-015306-us58wwmp 3441 5 48 48 CD cord-015306-us58wwmp 3441 6 hours hour NNS cord-015306-us58wwmp 3441 7 with with IN cord-015306-us58wwmp 3441 8 rapid rapid JJ cord-015306-us58wwmp 3441 9 normalization normalization NN cord-015306-us58wwmp 3441 10 of of IN cord-015306-us58wwmp 3441 11 respiratory respiratory JJ cord-015306-us58wwmp 3441 12 ventilation ventilation NN cord-015306-us58wwmp 3441 13 and and CC cord-015306-us58wwmp 3441 14 return return NN cord-015306-us58wwmp 3441 15 to to IN cord-015306-us58wwmp 3441 16 normal normal JJ cord-015306-us58wwmp 3441 17 and and CC cord-015306-us58wwmp 3441 18 well well RB cord-015306-us58wwmp 3441 19 tolerated tolerate VBN cord-015306-us58wwmp 3441 20 enteral enteral JJ cord-015306-us58wwmp 3441 21 nutrition nutrition NN cord-015306-us58wwmp 3441 22 . . . cord-015306-us58wwmp 3442 1 Conclusion conclusion NN cord-015306-us58wwmp 3442 2 : : : cord-015306-us58wwmp 3443 1 To to IN cord-015306-us58wwmp 3443 2 our -PRON- PRP$ cord-015306-us58wwmp 3443 3 knowledge knowledge NN cord-015306-us58wwmp 3443 4 , , , cord-015306-us58wwmp 3443 5 this this DT cord-015306-us58wwmp 3443 6 is be VBZ cord-015306-us58wwmp 3443 7 the the DT cord-015306-us58wwmp 3443 8 first first JJ cord-015306-us58wwmp 3443 9 case case NN cord-015306-us58wwmp 3443 10 reported report VBN cord-015306-us58wwmp 3443 11 of of IN cord-015306-us58wwmp 3443 12 portal portal NNP cord-015306-us58wwmp 3443 13 ascitis ascitis NNP cord-015306-us58wwmp 3443 14 noted note VBN cord-015306-us58wwmp 3443 15 after after IN cord-015306-us58wwmp 3443 16 palliative palliative JJ cord-015306-us58wwmp 3443 17 unilateral unilateral JJ cord-015306-us58wwmp 3443 18 nephrectomy nephrectomy NN cord-015306-us58wwmp 3443 19 to to TO cord-015306-us58wwmp 3443 20 facilitate facilitate VB cord-015306-us58wwmp 3443 21 pulmonary pulmonary JJ cord-015306-us58wwmp 3443 22 expansion expansion NN cord-015306-us58wwmp 3443 23 and and CC cord-015306-us58wwmp 3443 24 gastrointestinal gastrointestinal JJ cord-015306-us58wwmp 3443 25 function function NN cord-015306-us58wwmp 3443 26 in in IN cord-015306-us58wwmp 3443 27 ARPKD ARPKD NNP cord-015306-us58wwmp 3443 28 . . . cord-015306-us58wwmp 3444 1 Ascitis Ascitis NNP cord-015306-us58wwmp 3444 2 was be VBD cord-015306-us58wwmp 3444 3 resistant resistant JJ cord-015306-us58wwmp 3444 4 to to IN cord-015306-us58wwmp 3444 5 daily daily JJ cord-015306-us58wwmp 3444 6 albumin albumin NN cord-015306-us58wwmp 3444 7 perfusion perfusion NN cord-015306-us58wwmp 3444 8 and and CC cord-015306-us58wwmp 3444 9 repeated repeat VBN cord-015306-us58wwmp 3444 10 aspirations aspiration NNS cord-015306-us58wwmp 3444 11 but but CC cord-015306-us58wwmp 3444 12 was be VBD cord-015306-us58wwmp 3444 13 completely completely RB cord-015306-us58wwmp 3444 14 reversible reversible JJ cord-015306-us58wwmp 3444 15 after after IN cord-015306-us58wwmp 3444 16 bilateral bilateral JJ cord-015306-us58wwmp 3444 17 nephrectomy nephrectomy NN cord-015306-us58wwmp 3444 18 and and CC cord-015306-us58wwmp 3444 19 initiation initiation NN cord-015306-us58wwmp 3444 20 of of IN cord-015306-us58wwmp 3444 21 peritoneal peritoneal JJ cord-015306-us58wwmp 3444 22 dialysis dialysis NN cord-015306-us58wwmp 3444 23 . . . cord-015306-us58wwmp 3445 1 Early early JJ cord-015306-us58wwmp 3445 2 bilateral bilateral JJ cord-015306-us58wwmp 3445 3 nephrectomy nephrectomy NN cord-015306-us58wwmp 3445 4 at at IN cord-015306-us58wwmp 3445 5 2 2 CD cord-015306-us58wwmp 3445 6 months month NNS cord-015306-us58wwmp 3445 7 of of IN cord-015306-us58wwmp 3445 8 life life NN cord-015306-us58wwmp 3445 9 was be VBD cord-015306-us58wwmp 3445 10 probably probably RB cord-015306-us58wwmp 3445 11 the the DT cord-015306-us58wwmp 3445 12 ideal ideal JJ cord-015306-us58wwmp 3445 13 choice choice NN cord-015306-us58wwmp 3445 14 to to TO cord-015306-us58wwmp 3445 15 avoid avoid VB cord-015306-us58wwmp 3445 16 many many JJ cord-015306-us58wwmp 3445 17 complications complication NNS cord-015306-us58wwmp 3445 18 in in IN cord-015306-us58wwmp 3445 19 our -PRON- PRP$ cord-015306-us58wwmp 3445 20 infant infant NN cord-015306-us58wwmp 3445 21 due due IN cord-015306-us58wwmp 3445 22 to to IN cord-015306-us58wwmp 3445 23 abdominal abdominal JJ cord-015306-us58wwmp 3445 24 and and CC cord-015306-us58wwmp 3445 25 thoracic thoracic JJ cord-015306-us58wwmp 3445 26 compression compression NN cord-015306-us58wwmp 3445 27 by by IN cord-015306-us58wwmp 3445 28 massive massive JJ cord-015306-us58wwmp 3445 29 kidney kidney NN cord-015306-us58wwmp 3445 30 compression compression NN cord-015306-us58wwmp 3445 31 . . . cord-015306-us58wwmp 3446 1 Ethical ethical JJ cord-015306-us58wwmp 3446 2 considerations consideration NNS cord-015306-us58wwmp 3446 3 , , , cord-015306-us58wwmp 3446 4 therapeutic therapeutic JJ cord-015306-us58wwmp 3446 5 possibilities possibility NNS cord-015306-us58wwmp 3446 6 , , , cord-015306-us58wwmp 3446 7 and and CC cord-015306-us58wwmp 3446 8 parent parent NN cord-015306-us58wwmp 3446 9 consent consent NN cord-015306-us58wwmp 3446 10 should should MD cord-015306-us58wwmp 3446 11 be be VB cord-015306-us58wwmp 3446 12 discussed discuss VBN cord-015306-us58wwmp 3446 13 in in IN cord-015306-us58wwmp 3446 14 such such JJ cord-015306-us58wwmp 3446 15 challenging challenging JJ cord-015306-us58wwmp 3446 16 and and CC cord-015306-us58wwmp 3446 17 very very RB cord-015306-us58wwmp 3446 18 difficult difficult JJ cord-015306-us58wwmp 3446 19 cases case NNS cord-015306-us58wwmp 3446 20 . . . cord-015306-us58wwmp 3447 1 Abstract abstract JJ cord-015306-us58wwmp 3447 2 # # NN cord-015306-us58wwmp 3447 3 P P NNP cord-015306-us58wwmp 3447 4 - - HYPH cord-015306-us58wwmp 3447 5 SAT381 SAT381 NNP cord-015306-us58wwmp 3447 6 Serum Serum NNP cord-015306-us58wwmp 3447 7 hepcidin hepcidin NNS cord-015306-us58wwmp 3447 8 25 25 CD cord-015306-us58wwmp 3447 9 levels level NNS cord-015306-us58wwmp 3447 10 and and CC cord-015306-us58wwmp 3447 11 anemia anemia NN cord-015306-us58wwmp 3447 12 in in IN cord-015306-us58wwmp 3447 13 pediatric pediatric JJ cord-015306-us58wwmp 3447 14 chronic chronic JJ cord-015306-us58wwmp 3447 15 kidney kidney NN cord-015306-us58wwmp 3447 16 disease disease NN cord-015306-us58wwmp 3447 17 Objective Objective NNP cord-015306-us58wwmp 3448 1 : : : cord-015306-us58wwmp 3448 2 Hepcidin Hepcidin NNP cord-015306-us58wwmp 3448 3 restricts restrict VBZ cord-015306-us58wwmp 3448 4 the the DT cord-015306-us58wwmp 3448 5 availability availability NN cord-015306-us58wwmp 3448 6 of of IN cord-015306-us58wwmp 3448 7 iron iron NN cord-015306-us58wwmp 3448 8 from from IN cord-015306-us58wwmp 3448 9 its -PRON- PRP$ cord-015306-us58wwmp 3448 10 stores store NNS cord-015306-us58wwmp 3448 11 for for IN cord-015306-us58wwmp 3448 12 erythropoiesis erythropoiesis NN cord-015306-us58wwmp 3448 13 resulting result VBG cord-015306-us58wwmp 3448 14 in in IN cord-015306-us58wwmp 3448 15 a a DT cord-015306-us58wwmp 3448 16 functional functional JJ cord-015306-us58wwmp 3448 17 deficiency deficiency NN cord-015306-us58wwmp 3448 18 of of IN cord-015306-us58wwmp 3448 19 iron iron NN cord-015306-us58wwmp 3448 20 and and CC cord-015306-us58wwmp 3448 21 hyporesponsiveness hyporesponsiveness NN cord-015306-us58wwmp 3448 22 to to TO cord-015306-us58wwmp 3448 23 erythropoiesis erythropoiesis VB cord-015306-us58wwmp 3448 24 stimulating stimulate VBG cord-015306-us58wwmp 3448 25 agents agent NNS cord-015306-us58wwmp 3448 26 . . . cord-015306-us58wwmp 3449 1 The the DT cord-015306-us58wwmp 3449 2 objectives objective NNS cord-015306-us58wwmp 3449 3 were be VBD cord-015306-us58wwmp 3449 4 to to TO cord-015306-us58wwmp 3449 5 estimate estimate VB cord-015306-us58wwmp 3449 6 the the DT cord-015306-us58wwmp 3449 7 serum serum NN cord-015306-us58wwmp 3449 8 hepcidin hepcidin NNP cord-015306-us58wwmp 3449 9 25 25 CD cord-015306-us58wwmp 3449 10 in in IN cord-015306-us58wwmp 3449 11 children child NNS cord-015306-us58wwmp 3449 12 with with IN cord-015306-us58wwmp 3449 13 chronic chronic JJ cord-015306-us58wwmp 3449 14 kidney kidney NN cord-015306-us58wwmp 3449 15 disease disease NN cord-015306-us58wwmp 3449 16 stage stage NN cord-015306-us58wwmp 3449 17 II II NNP cord-015306-us58wwmp 3449 18 to to IN cord-015306-us58wwmp 3449 19 IV IV NNP cord-015306-us58wwmp 3449 20 and and CC cord-015306-us58wwmp 3449 21 correlate correlate VB cord-015306-us58wwmp 3449 22 it -PRON- PRP cord-015306-us58wwmp 3449 23 with with IN cord-015306-us58wwmp 3449 24 hemoglobin hemoglobin NN cord-015306-us58wwmp 3449 25 , , , cord-015306-us58wwmp 3449 26 iron iron NN cord-015306-us58wwmp 3449 27 status status NN cord-015306-us58wwmp 3449 28 ( ( -LRB- cord-015306-us58wwmp 3449 29 serum serum NN cord-015306-us58wwmp 3449 30 ferritin ferritin NN cord-015306-us58wwmp 3449 31 and and CC cord-015306-us58wwmp 3449 32 transferrin transferrin NN cord-015306-us58wwmp 3449 33 saturation saturation NN cord-015306-us58wwmp 3449 34 ) ) -RRB- cord-015306-us58wwmp 3449 35 , , , cord-015306-us58wwmp 3449 36 inflammation inflammation NN cord-015306-us58wwmp 3449 37 ( ( -LRB- cord-015306-us58wwmp 3449 38 C C NNP cord-015306-us58wwmp 3449 39 reactive reactive JJ cord-015306-us58wwmp 3449 40 protein protein NN cord-015306-us58wwmp 3449 41 ) ) -RRB- cord-015306-us58wwmp 3449 42 and and CC cord-015306-us58wwmp 3449 43 estimated estimate VBD cord-015306-us58wwmp 3449 44 glomerular glomerular JJ cord-015306-us58wwmp 3449 45 filtration filtration NN cord-015306-us58wwmp 3449 46 rate rate NN cord-015306-us58wwmp 3449 47 ( ( -LRB- cord-015306-us58wwmp 3449 48 eGFR egfr NN cord-015306-us58wwmp 3449 49 ) ) -RRB- cord-015306-us58wwmp 3449 50 . . . cord-015306-us58wwmp 3450 1 Methods method NNS cord-015306-us58wwmp 3450 2 : : : cord-015306-us58wwmp 3450 3 It -PRON- PRP cord-015306-us58wwmp 3450 4 was be VBD cord-015306-us58wwmp 3450 5 a a DT cord-015306-us58wwmp 3450 6 cross cross JJ cord-015306-us58wwmp 3450 7 sectional sectional JJ cord-015306-us58wwmp 3450 8 study study NN cord-015306-us58wwmp 3450 9 . . . cord-015306-us58wwmp 3451 1 Children child NNS cord-015306-us58wwmp 3451 2 aged age VBN cord-015306-us58wwmp 3451 3 2 2 CD cord-015306-us58wwmp 3451 4 to to TO cord-015306-us58wwmp 3451 5 18 18 CD cord-015306-us58wwmp 3451 6 years year NNS cord-015306-us58wwmp 3451 7 with with IN cord-015306-us58wwmp 3451 8 CKD CKD NNP cord-015306-us58wwmp 3451 9 stage stage NN cord-015306-us58wwmp 3452 1 2 2 LS cord-015306-us58wwmp 3452 2 - - SYM cord-015306-us58wwmp 3452 3 4 4 CD cord-015306-us58wwmp 3452 4 on on IN cord-015306-us58wwmp 3452 5 stable stable JJ cord-015306-us58wwmp 3452 6 dose dose NN cord-015306-us58wwmp 3452 7 of of IN cord-015306-us58wwmp 3452 8 iron iron NN cord-015306-us58wwmp 3452 9 and and CC cord-015306-us58wwmp 3452 10 or or CC cord-015306-us58wwmp 3452 11 erythropoetin erythropoetin VBZ cord-015306-us58wwmp 3452 12 for for IN cord-015306-us58wwmp 3452 13 the the DT cord-015306-us58wwmp 3452 14 last last JJ cord-015306-us58wwmp 3452 15 4 4 CD cord-015306-us58wwmp 3452 16 weeks week NNS cord-015306-us58wwmp 3452 17 were be VBD cord-015306-us58wwmp 3452 18 included include VBN cord-015306-us58wwmp 3452 19 . . . cord-015306-us58wwmp 3453 1 Children child NNS cord-015306-us58wwmp 3453 2 with with IN cord-015306-us58wwmp 3453 3 anemia anemia NN cord-015306-us58wwmp 3453 4 due due IN cord-015306-us58wwmp 3453 5 to to IN cord-015306-us58wwmp 3453 6 other other JJ cord-015306-us58wwmp 3453 7 causes cause NNS cord-015306-us58wwmp 3453 8 , , , cord-015306-us58wwmp 3453 9 severe severe JJ cord-015306-us58wwmp 3453 10 acute acute JJ cord-015306-us58wwmp 3453 11 infection infection NN cord-015306-us58wwmp 3453 12 , , , cord-015306-us58wwmp 3453 13 chronic chronic JJ cord-015306-us58wwmp 3453 14 cardiac cardiac JJ cord-015306-us58wwmp 3453 15 or or CC cord-015306-us58wwmp 3453 16 respiratory respiratory JJ cord-015306-us58wwmp 3453 17 conditions condition NNS cord-015306-us58wwmp 3453 18 and and CC cord-015306-us58wwmp 3453 19 those those DT cord-015306-us58wwmp 3453 20 who who WP cord-015306-us58wwmp 3453 21 received receive VBD cord-015306-us58wwmp 3453 22 parenteral parenteral JJ cord-015306-us58wwmp 3453 23 iron iron NN cord-015306-us58wwmp 3453 24 and and CC cord-015306-us58wwmp 3453 25 or or CC cord-015306-us58wwmp 3453 26 blood blood NN cord-015306-us58wwmp 3453 27 transfusion transfusion NN cord-015306-us58wwmp 3453 28 in in IN cord-015306-us58wwmp 3453 29 last last JJ cord-015306-us58wwmp 3453 30 4 4 CD cord-015306-us58wwmp 3453 31 weeks week NNS cord-015306-us58wwmp 3453 32 were be VBD cord-015306-us58wwmp 3453 33 excluded exclude VBN cord-015306-us58wwmp 3453 34 . . . cord-015306-us58wwmp 3454 1 Hemoglobin hemoglobin NN cord-015306-us58wwmp 3454 2 , , , cord-015306-us58wwmp 3454 3 serum serum NN cord-015306-us58wwmp 3454 4 ferritin ferritin NN cord-015306-us58wwmp 3454 5 , , , cord-015306-us58wwmp 3454 6 transferrin transferrin NN cord-015306-us58wwmp 3454 7 saturation saturation NN cord-015306-us58wwmp 3454 8 , , , cord-015306-us58wwmp 3454 9 C C NNP cord-015306-us58wwmp 3454 10 reactive reactive JJ cord-015306-us58wwmp 3454 11 protein protein NN cord-015306-us58wwmp 3454 12 were be VBD cord-015306-us58wwmp 3454 13 assessed assess VBN cord-015306-us58wwmp 3454 14 . . . cord-015306-us58wwmp 3455 1 Serum serum NN cord-015306-us58wwmp 3455 2 hepcidin hepcidin NN cord-015306-us58wwmp 3455 3 25 25 CD cord-015306-us58wwmp 3455 4 levels level NNS cord-015306-us58wwmp 3455 5 were be VBD cord-015306-us58wwmp 3455 6 estimated estimate VBN cord-015306-us58wwmp 3455 7 using use VBG cord-015306-us58wwmp 3455 8 a a DT cord-015306-us58wwmp 3455 9 ELISA ELISA NNP cord-015306-us58wwmp 3455 10 based base VBN cord-015306-us58wwmp 3455 11 kit kit NN cord-015306-us58wwmp 3455 12 in in IN cord-015306-us58wwmp 3455 13 the the DT cord-015306-us58wwmp 3455 14 cohort cohort NN cord-015306-us58wwmp 3455 15 as as RB cord-015306-us58wwmp 3455 16 well well RB cord-015306-us58wwmp 3455 17 as as IN cord-015306-us58wwmp 3455 18 in in IN cord-015306-us58wwmp 3455 19 15 15 CD cord-015306-us58wwmp 3455 20 age age NN cord-015306-us58wwmp 3455 21 and and CC cord-015306-us58wwmp 3455 22 sex sex NN cord-015306-us58wwmp 3455 23 matched match VBD cord-015306-us58wwmp 3455 24 normal normal JJ cord-015306-us58wwmp 3455 25 children child NNS cord-015306-us58wwmp 3455 26 to to TO cord-015306-us58wwmp 3455 27 estimate estimate VB cord-015306-us58wwmp 3455 28 the the DT cord-015306-us58wwmp 3455 29 levels level NNS cord-015306-us58wwmp 3455 30 in in IN cord-015306-us58wwmp 3455 31 normal normal JJ cord-015306-us58wwmp 3455 32 population population NN cord-015306-us58wwmp 3455 33 . . . cord-015306-us58wwmp 3456 1 Multivariate multivariate JJ cord-015306-us58wwmp 3456 2 regression regression NN cord-015306-us58wwmp 3456 3 analysis analysis NN cord-015306-us58wwmp 3456 4 was be VBD cord-015306-us58wwmp 3456 5 used use VBN cord-015306-us58wwmp 3456 6 to to TO cord-015306-us58wwmp 3456 7 assess assess VB cord-015306-us58wwmp 3456 8 the the DT cord-015306-us58wwmp 3456 9 relationship relationship NN cord-015306-us58wwmp 3456 10 between between IN cord-015306-us58wwmp 3456 11 hepcidin hepcidin NNS cord-015306-us58wwmp 3456 12 and and CC cord-015306-us58wwmp 3456 13 hemoglobin hemoglobin NN cord-015306-us58wwmp 3456 14 , , , cord-015306-us58wwmp 3456 15 iron iron NN cord-015306-us58wwmp 3456 16 status status NN cord-015306-us58wwmp 3456 17 , , , cord-015306-us58wwmp 3456 18 inflammation inflammation NN cord-015306-us58wwmp 3456 19 and and CC cord-015306-us58wwmp 3456 20 eGFR egfr NN cord-015306-us58wwmp 3456 21 . . . cord-015306-us58wwmp 3457 1 Results result NNS cord-015306-us58wwmp 3457 2 : : : cord-015306-us58wwmp 3458 1 Forty forty CD cord-015306-us58wwmp 3458 2 children child NNS cord-015306-us58wwmp 3458 3 were be VBD cord-015306-us58wwmp 3458 4 recruited recruit VBN cord-015306-us58wwmp 3458 5 into into IN cord-015306-us58wwmp 3458 6 the the DT cord-015306-us58wwmp 3458 7 study study NN cord-015306-us58wwmp 3458 8 . . . cord-015306-us58wwmp 3459 1 The the DT cord-015306-us58wwmp 3459 2 mean mean JJ cord-015306-us58wwmp 3459 3 age age NN cord-015306-us58wwmp 3459 4 of of IN cord-015306-us58wwmp 3459 5 children child NNS cord-015306-us58wwmp 3459 6 was be VBD cord-015306-us58wwmp 3459 7 9.1 9.1 CD cord-015306-us58wwmp 3459 8 + + SYM cord-015306-us58wwmp 3459 9 4.5 4.5 CD cord-015306-us58wwmp 3459 10 years year NNS cord-015306-us58wwmp 3459 11 . . . cord-015306-us58wwmp 3460 1 Around around IN cord-015306-us58wwmp 3460 2 30 30 CD cord-015306-us58wwmp 3460 3 % % NN cord-015306-us58wwmp 3460 4 , , , cord-015306-us58wwmp 3460 5 28 28 CD cord-015306-us58wwmp 3460 6 % % NN cord-015306-us58wwmp 3460 7 and and CC cord-015306-us58wwmp 3460 8 42 42 CD cord-015306-us58wwmp 3460 9 % % NN cord-015306-us58wwmp 3460 10 of of IN cord-015306-us58wwmp 3460 11 children child NNS cord-015306-us58wwmp 3460 12 had have VBD cord-015306-us58wwmp 3460 13 CKD CKD NNP cord-015306-us58wwmp 3460 14 stage stage NN cord-015306-us58wwmp 3460 15 II II NNP cord-015306-us58wwmp 3460 16 , , , cord-015306-us58wwmp 3460 17 III III NNP cord-015306-us58wwmp 3460 18 and and CC cord-015306-us58wwmp 3460 19 IV IV NNP cord-015306-us58wwmp 3460 20 respectively respectively RB cord-015306-us58wwmp 3460 21 . . . cord-015306-us58wwmp 3461 1 The the DT cord-015306-us58wwmp 3461 2 mean mean JJ cord-015306-us58wwmp 3461 3 serum serum NN cord-015306-us58wwmp 3461 4 hepcidinlevels hepcidinlevel NNS cord-015306-us58wwmp 3461 5 in in IN cord-015306-us58wwmp 3461 6 children child NNS cord-015306-us58wwmp 3461 7 with with IN cord-015306-us58wwmp 3461 8 CKD CKD NNP cord-015306-us58wwmp 3461 9 ( ( -LRB- cord-015306-us58wwmp 3461 10 55.87 55.87 CD cord-015306-us58wwmp 3461 11 + + SYM cord-015306-us58wwmp 3461 12 14.27ng 14.27ng CD cord-015306-us58wwmp 3461 13 / / SYM cord-015306-us58wwmp 3461 14 ml ml NN cord-015306-us58wwmp 3461 15 ) ) -RRB- cord-015306-us58wwmp 3461 16 was be VBD cord-015306-us58wwmp 3461 17 significantly significantly RB cord-015306-us58wwmp 3461 18 higher high JJR cord-015306-us58wwmp 3461 19 than than IN cord-015306-us58wwmp 3461 20 controls control NNS cord-015306-us58wwmp 3461 21 ( ( -LRB- cord-015306-us58wwmp 3461 22 11.17 11.17 CD cord-015306-us58wwmp 3461 23 + + SYM cord-015306-us58wwmp 3461 24 4.38ng 4.38ng CD cord-015306-us58wwmp 3461 25 / / SYM cord-015306-us58wwmp 3461 26 ml ml NN cord-015306-us58wwmp 3461 27 ) ) -RRB- cord-015306-us58wwmp 3461 28 . . . cord-015306-us58wwmp 3462 1 Conclusion conclusion NN cord-015306-us58wwmp 3462 2 : : : cord-015306-us58wwmp 3463 1 Serum serum NN cord-015306-us58wwmp 3463 2 hepcidin hepcidin NN cord-015306-us58wwmp 3463 3 levels level NNS cord-015306-us58wwmp 3463 4 showed show VBD cord-015306-us58wwmp 3463 5 an an DT cord-015306-us58wwmp 3463 6 increasing increase VBG cord-015306-us58wwmp 3463 7 trend trend NN cord-015306-us58wwmp 3463 8 with with IN cord-015306-us58wwmp 3463 9 decrease decrease NN cord-015306-us58wwmp 3463 10 in in IN cord-015306-us58wwmp 3463 11 eGFR egfr NN cord-015306-us58wwmp 3463 12 , , , cord-015306-us58wwmp 3463 13 but but CC cord-015306-us58wwmp 3463 14 this this DT cord-015306-us58wwmp 3463 15 was be VBD cord-015306-us58wwmp 3463 16 not not RB cord-015306-us58wwmp 3463 17 statistically statistically RB cord-015306-us58wwmp 3463 18 significant significant JJ cord-015306-us58wwmp 3463 19 . . . cord-015306-us58wwmp 3464 1 The the DT cord-015306-us58wwmp 3464 2 mean mean JJ cord-015306-us58wwmp 3464 3 haemoglobin haemoglobin NN cord-015306-us58wwmp 3464 4 was be VBD cord-015306-us58wwmp 3464 5 10.76 10.76 CD cord-015306-us58wwmp 3464 6 + + SYM cord-015306-us58wwmp 3464 7 1.59g 1.59g CD cord-015306-us58wwmp 3464 8 / / SYM cord-015306-us58wwmp 3464 9 dL dl NN cord-015306-us58wwmp 3464 10 , , , cord-015306-us58wwmp 3464 11 the the DT cord-015306-us58wwmp 3464 12 mean mean JJ cord-015306-us58wwmp 3464 13 ferritin ferritin NN cord-015306-us58wwmp 3464 14 was be VBD cord-015306-us58wwmp 3464 15 43.27 43.27 CD cord-015306-us58wwmp 3464 16 + + SYM cord-015306-us58wwmp 3464 17 38.3ng 38.3ng CD cord-015306-us58wwmp 3464 18 / / SYM cord-015306-us58wwmp 3464 19 ml ml NNS cord-015306-us58wwmp 3464 20 , , , cord-015306-us58wwmp 3464 21 the the DT cord-015306-us58wwmp 3464 22 mean mean JJ cord-015306-us58wwmp 3464 23 transferrin transferrin NN cord-015306-us58wwmp 3464 24 saturation saturation NN cord-015306-us58wwmp 3464 25 was be VBD cord-015306-us58wwmp 3464 26 21.68 21.68 CD cord-015306-us58wwmp 3464 27 + + SYM cord-015306-us58wwmp 3464 28 11.5 11.5 CD cord-015306-us58wwmp 3464 29 % % NN cord-015306-us58wwmp 3464 30 . . . cord-015306-us58wwmp 3465 1 Anemia anemia NN cord-015306-us58wwmp 3465 2 and and CC cord-015306-us58wwmp 3465 3 absolute absolute JJ cord-015306-us58wwmp 3465 4 iron iron NN cord-015306-us58wwmp 3465 5 deficiency deficiency NN cord-015306-us58wwmp 3465 6 was be VBD cord-015306-us58wwmp 3465 7 seen see VBN cord-015306-us58wwmp 3465 8 in in IN cord-015306-us58wwmp 3465 9 100 100 CD cord-015306-us58wwmp 3465 10 % % NN cord-015306-us58wwmp 3465 11 of of IN cord-015306-us58wwmp 3465 12 our -PRON- PRP$ cord-015306-us58wwmp 3465 13 cohort cohort NN cord-015306-us58wwmp 3465 14 and and CC cord-015306-us58wwmp 3465 15 worsened worsen VBD cord-015306-us58wwmp 3465 16 with with IN cord-015306-us58wwmp 3465 17 increasing increase VBG cord-015306-us58wwmp 3465 18 stages stage NNS cord-015306-us58wwmp 3465 19 of of IN cord-015306-us58wwmp 3465 20 CKD CKD NNP cord-015306-us58wwmp 3465 21 . . . cord-015306-us58wwmp 3466 1 serumhepcidin serumhepcidin NNP cord-015306-us58wwmp 3466 2 levels level NNS cord-015306-us58wwmp 3466 3 did do VBD cord-015306-us58wwmp 3466 4 not not RB cord-015306-us58wwmp 3466 5 correlate correlate VB cord-015306-us58wwmp 3466 6 significantly significantly RB cord-015306-us58wwmp 3466 7 with with IN cord-015306-us58wwmp 3466 8 haemoglobin haemoglobin NN cord-015306-us58wwmp 3466 9 , , , cord-015306-us58wwmp 3466 10 ferritin ferritin NN cord-015306-us58wwmp 3466 11 or or CC cord-015306-us58wwmp 3466 12 with with IN cord-015306-us58wwmp 3466 13 C C NNP cord-015306-us58wwmp 3466 14 - - HYPH cord-015306-us58wwmp 3466 15 reactive reactive JJ cord-015306-us58wwmp 3466 16 protein protein NN cord-015306-us58wwmp 3466 17 . . . cord-015306-us58wwmp 3467 1 Objectives objective NNS cord-015306-us58wwmp 3467 2 , , , cord-015306-us58wwmp 3467 3 Methods Methods NNPS cord-015306-us58wwmp 3467 4 and and CC cord-015306-us58wwmp 3467 5 Results result NNS cord-015306-us58wwmp 3467 6 : : : cord-015306-us58wwmp 3467 7 Presenting present VBG cord-015306-us58wwmp 3467 8 a a DT cord-015306-us58wwmp 3467 9 16-year 16-year JJ cord-015306-us58wwmp 3467 10 old old JJ cord-015306-us58wwmp 3467 11 Armenian armenian JJ cord-015306-us58wwmp 3467 12 patient patient NN cord-015306-us58wwmp 3467 13 who who WP cord-015306-us58wwmp 3467 14 developed develop VBD cord-015306-us58wwmp 3467 15 a a DT cord-015306-us58wwmp 3467 16 secondary secondary JJ cord-015306-us58wwmp 3467 17 amyloidosis amyloidosis NN cord-015306-us58wwmp 3467 18 on on IN cord-015306-us58wwmp 3467 19 top top NN cord-015306-us58wwmp 3467 20 of of IN cord-015306-us58wwmp 3467 21 a a DT cord-015306-us58wwmp 3467 22 familial familial JJ cord-015306-us58wwmp 3467 23 Mediterranean Mediterranean NNP cord-015306-us58wwmp 3467 24 fever fever NN cord-015306-us58wwmp 3467 25 ( ( -LRB- cord-015306-us58wwmp 3467 26 FMF FMF NNP cord-015306-us58wwmp 3467 27 ) ) -RRB- cord-015306-us58wwmp 3467 28 and and CC cord-015306-us58wwmp 3467 29 moved move VBD cord-015306-us58wwmp 3467 30 to to IN cord-015306-us58wwmp 3467 31 Germany Germany NNP cord-015306-us58wwmp 3467 32 4 4 CD cord-015306-us58wwmp 3467 33 years year NNS cord-015306-us58wwmp 3467 34 ago ago RB cord-015306-us58wwmp 3467 35 . . . cord-015306-us58wwmp 3468 1 At at IN cord-015306-us58wwmp 3468 2 the the DT cord-015306-us58wwmp 3468 3 time time NN cord-015306-us58wwmp 3468 4 of of IN cord-015306-us58wwmp 3468 5 the the DT cord-015306-us58wwmp 3468 6 move move NN cord-015306-us58wwmp 3468 7 the the DT cord-015306-us58wwmp 3468 8 patient patient NN cord-015306-us58wwmp 3468 9 had have VBD cord-015306-us58wwmp 3468 10 already already RB cord-015306-us58wwmp 3468 11 a a DT cord-015306-us58wwmp 3468 12 terminal terminal JJ cord-015306-us58wwmp 3468 13 renal renal JJ cord-015306-us58wwmp 3468 14 insufficiency insufficiency NN cord-015306-us58wwmp 3468 15 and and CC cord-015306-us58wwmp 3468 16 received receive VBD cord-015306-us58wwmp 3468 17 intermittent intermittent JJ cord-015306-us58wwmp 3468 18 hemodialysis hemodialysis NN cord-015306-us58wwmp 3468 19 . . . cord-015306-us58wwmp 3469 1 Despite despite IN cord-015306-us58wwmp 3469 2 the the DT cord-015306-us58wwmp 3469 3 therapy therapy NN cord-015306-us58wwmp 3469 4 with with IN cord-015306-us58wwmp 3469 5 colchicine colchicine JJ cord-015306-us58wwmp 3469 6 moderate moderate JJ cord-015306-us58wwmp 3469 7 attacks attack NNS cord-015306-us58wwmp 3469 8 of of IN cord-015306-us58wwmp 3469 9 the the DT cord-015306-us58wwmp 3469 10 FMF FMF NNP cord-015306-us58wwmp 3469 11 occurred occur VBD cord-015306-us58wwmp 3469 12 with with IN cord-015306-us58wwmp 3469 13 an an DT cord-015306-us58wwmp 3469 14 interval interval NN cord-015306-us58wwmp 3469 15 of of IN cord-015306-us58wwmp 3469 16 4 4 CD cord-015306-us58wwmp 3469 17 weeks week NNS cord-015306-us58wwmp 3469 18 and and CC cord-015306-us58wwmp 3469 19 inflammatory inflammatory JJ cord-015306-us58wwmp 3469 20 parameters parameter NNS cord-015306-us58wwmp 3469 21 were be VBD cord-015306-us58wwmp 3469 22 permanently permanently RB cord-015306-us58wwmp 3469 23 elevated elevate VBN cord-015306-us58wwmp 3469 24 . . . cord-015306-us58wwmp 3470 1 The the DT cord-015306-us58wwmp 3470 2 dosage dosage NN cord-015306-us58wwmp 3470 3 of of IN cord-015306-us58wwmp 3470 4 colchicine colchicine NNP cord-015306-us58wwmp 3470 5 was be VBD cord-015306-us58wwmp 3470 6 titrated titrate VBN cord-015306-us58wwmp 3470 7 up up RP cord-015306-us58wwmp 3470 8 to to IN cord-015306-us58wwmp 3470 9 3 3 CD cord-015306-us58wwmp 3470 10 mg mg NN cord-015306-us58wwmp 3470 11 per per IN cord-015306-us58wwmp 3470 12 day day NN cord-015306-us58wwmp 3470 13 . . . cord-015306-us58wwmp 3471 1 As as IN cord-015306-us58wwmp 3471 2 a a DT cord-015306-us58wwmp 3471 3 consequence consequence NN cord-015306-us58wwmp 3471 4 diarrhea diarrhea NN cord-015306-us58wwmp 3471 5 occurred occur VBD cord-015306-us58wwmp 3471 6 and and CC cord-015306-us58wwmp 3471 7 the the DT cord-015306-us58wwmp 3471 8 dosage dosage NN cord-015306-us58wwmp 3471 9 had have VBD cord-015306-us58wwmp 3471 10 to to TO cord-015306-us58wwmp 3471 11 be be VB cord-015306-us58wwmp 3471 12 decreased decrease VBN cord-015306-us58wwmp 3471 13 . . . cord-015306-us58wwmp 3472 1 Over over IN cord-015306-us58wwmp 3472 2 the the DT cord-015306-us58wwmp 3472 3 course course NN cord-015306-us58wwmp 3472 4 the the DT cord-015306-us58wwmp 3472 5 amyloidosis amyloidosis NN cord-015306-us58wwmp 3472 6 progressed progress VBD cord-015306-us58wwmp 3472 7 and and CC cord-015306-us58wwmp 3472 8 affected affect VBD cord-015306-us58wwmp 3472 9 all all DT cord-015306-us58wwmp 3472 10 internal internal JJ cord-015306-us58wwmp 3472 11 organs organ NNS cord-015306-us58wwmp 3472 12 including include VBG cord-015306-us58wwmp 3472 13 heart heart NN cord-015306-us58wwmp 3472 14 and and CC cord-015306-us58wwmp 3472 15 bowel bowel NN cord-015306-us58wwmp 3472 16 . . . cord-015306-us58wwmp 3473 1 The the DT cord-015306-us58wwmp 3473 2 combination combination NN cord-015306-us58wwmp 3473 3 of of IN cord-015306-us58wwmp 3473 4 inflammation inflammation NN cord-015306-us58wwmp 3473 5 , , , cord-015306-us58wwmp 3473 6 uremia uremia NN cord-015306-us58wwmp 3473 7 and and CC cord-015306-us58wwmp 3473 8 amyloidosis amyloidosis NN cord-015306-us58wwmp 3473 9 led lead VBD cord-015306-us58wwmp 3473 10 to to IN cord-015306-us58wwmp 3473 11 malnutrition malnutrition NN cord-015306-us58wwmp 3473 12 ( ( -LRB- cord-015306-us58wwmp 3473 13 BMI BMI NNP cord-015306-us58wwmp 3473 14 14 14 CD cord-015306-us58wwmp 3473 15 kg kg NNP cord-015306-us58wwmp 3473 16 / / SYM cord-015306-us58wwmp 3473 17 m2 m2 NNP cord-015306-us58wwmp 3473 18 ) ) -RRB- cord-015306-us58wwmp 3473 19 . . . cord-015306-us58wwmp 3474 1 At at IN cord-015306-us58wwmp 3474 2 the the DT cord-015306-us58wwmp 3474 3 age age NN cord-015306-us58wwmp 3474 4 of of IN cord-015306-us58wwmp 3474 5 16 16 CD cord-015306-us58wwmp 3474 6 years year NNS cord-015306-us58wwmp 3474 7 the the DT cord-015306-us58wwmp 3474 8 most most RBS cord-015306-us58wwmp 3474 9 severe severe JJ cord-015306-us58wwmp 3474 10 colitis colitis NN cord-015306-us58wwmp 3474 11 with with IN cord-015306-us58wwmp 3474 12 peritonitis peritonitis NN cord-015306-us58wwmp 3474 13 and and CC cord-015306-us58wwmp 3474 14 paralytic paralytic JJ cord-015306-us58wwmp 3474 15 ileus ileus NN cord-015306-us58wwmp 3474 16 occurred occur VBD cord-015306-us58wwmp 3474 17 . . . cord-015306-us58wwmp 3475 1 The the DT cord-015306-us58wwmp 3475 2 treatment treatment NN cord-015306-us58wwmp 3475 3 with with IN cord-015306-us58wwmp 3475 4 colchicine colchicine NNP cord-015306-us58wwmp 3475 5 was be VBD cord-015306-us58wwmp 3475 6 paused pause VBN cord-015306-us58wwmp 3475 7 in in IN cord-015306-us58wwmp 3475 8 assumption assumption NN cord-015306-us58wwmp 3475 9 of of IN cord-015306-us58wwmp 3475 10 a a DT cord-015306-us58wwmp 3475 11 toxic toxic JJ cord-015306-us58wwmp 3475 12 effect effect NN cord-015306-us58wwmp 3475 13 . . . cord-015306-us58wwmp 3476 1 After after IN cord-015306-us58wwmp 3476 2 improvement improvement NN cord-015306-us58wwmp 3476 3 of of IN cord-015306-us58wwmp 3476 4 the the DT cord-015306-us58wwmp 3476 5 diarrhea diarrhea NN cord-015306-us58wwmp 3476 6 but but CC cord-015306-us58wwmp 3476 7 still still RB cord-015306-us58wwmp 3476 8 persisting persist VBG cord-015306-us58wwmp 3476 9 abdominal abdominal JJ cord-015306-us58wwmp 3476 10 pain pain NN cord-015306-us58wwmp 3476 11 the the DT cord-015306-us58wwmp 3476 12 colchicine colchicine NNP cord-015306-us58wwmp 3476 13 treatment treatment NN cord-015306-us58wwmp 3476 14 was be VBD cord-015306-us58wwmp 3476 15 slowly slowly RB cord-015306-us58wwmp 3476 16 started start VBN cord-015306-us58wwmp 3476 17 again again RB cord-015306-us58wwmp 3476 18 . . . cord-015306-us58wwmp 3477 1 Shortly shortly RB cord-015306-us58wwmp 3477 2 afterwards afterwards RB cord-015306-us58wwmp 3477 3 a a DT cord-015306-us58wwmp 3477 4 very very RB cord-015306-us58wwmp 3477 5 severe severe JJ cord-015306-us58wwmp 3477 6 attack attack NN cord-015306-us58wwmp 3477 7 of of IN cord-015306-us58wwmp 3477 8 the the DT cord-015306-us58wwmp 3477 9 FMF FMF NNP cord-015306-us58wwmp 3477 10 developed develop VBN cord-015306-us58wwmp 3477 11 with with IN cord-015306-us58wwmp 3477 12 an an DT cord-015306-us58wwmp 3477 13 accompanied accompany VBN cord-015306-us58wwmp 3477 14 cardiovascular cardiovascular JJ cord-015306-us58wwmp 3477 15 insufficiency insufficiency NN cord-015306-us58wwmp 3477 16 . . . cord-015306-us58wwmp 3478 1 The the DT cord-015306-us58wwmp 3478 2 treatment treatment NN cord-015306-us58wwmp 3478 3 with with IN cord-015306-us58wwmp 3478 4 a a DT cord-015306-us58wwmp 3478 5 single single JJ cord-015306-us58wwmp 3478 6 high high JJ cord-015306-us58wwmp 3478 7 - - HYPH cord-015306-us58wwmp 3478 8 dose dose NN cord-015306-us58wwmp 3478 9 of of IN cord-015306-us58wwmp 3478 10 methylprednisolone methylprednisolone NN cord-015306-us58wwmp 3478 11 and and CC cord-015306-us58wwmp 3478 12 the the DT cord-015306-us58wwmp 3478 13 inhibition inhibition NN cord-015306-us58wwmp 3478 14 of of IN cord-015306-us58wwmp 3478 15 interleukin interleukin NN cord-015306-us58wwmp 3478 16 1 1 CD cord-015306-us58wwmp 3478 17 with with IN cord-015306-us58wwmp 3478 18 anakinra anakinra NNP cord-015306-us58wwmp 3478 19 ( ( -LRB- cord-015306-us58wwmp 3478 20 1 1 CD cord-015306-us58wwmp 3478 21 mg mg NNP cord-015306-us58wwmp 3478 22 / / SYM cord-015306-us58wwmp 3478 23 kg kg NNP cord-015306-us58wwmp 3478 24 , , , cord-015306-us58wwmp 3478 25 given give VBN cord-015306-us58wwmp 3478 26 after after IN cord-015306-us58wwmp 3478 27 dialysis dialysis NN cord-015306-us58wwmp 3478 28 ) ) -RRB- cord-015306-us58wwmp 3478 29 led lead VBD cord-015306-us58wwmp 3478 30 only only RB cord-015306-us58wwmp 3478 31 to to IN cord-015306-us58wwmp 3478 32 a a DT cord-015306-us58wwmp 3478 33 short short JJ cord-015306-us58wwmp 3478 34 remission remission NN cord-015306-us58wwmp 3478 35 . . . cord-015306-us58wwmp 3479 1 The the DT cord-015306-us58wwmp 3479 2 high high JJ cord-015306-us58wwmp 3479 3 - - HYPH cord-015306-us58wwmp 3479 4 dose dose NN cord-015306-us58wwmp 3479 5 methylprednisolone methylprednisolone NN cord-015306-us58wwmp 3479 6 treatment treatment NN cord-015306-us58wwmp 3479 7 was be VBD cord-015306-us58wwmp 3479 8 therefore therefore RB cord-015306-us58wwmp 3479 9 repeated repeat VBN cord-015306-us58wwmp 3479 10 three three CD cord-015306-us58wwmp 3479 11 times time NNS cord-015306-us58wwmp 3479 12 and and CC cord-015306-us58wwmp 3479 13 anakinra anakinra NNP cord-015306-us58wwmp 3479 14 was be VBD cord-015306-us58wwmp 3479 15 given give VBN cord-015306-us58wwmp 3479 16 on on IN cord-015306-us58wwmp 3479 17 a a DT cord-015306-us58wwmp 3479 18 daily daily JJ cord-015306-us58wwmp 3479 19 basis basis NN cord-015306-us58wwmp 3479 20 . . . cord-015306-us58wwmp 3480 1 Since since IN cord-015306-us58wwmp 3480 2 then then RB cord-015306-us58wwmp 3480 3 no no DT cord-015306-us58wwmp 3480 4 new new JJ cord-015306-us58wwmp 3480 5 attack attack NN cord-015306-us58wwmp 3480 6 of of IN cord-015306-us58wwmp 3480 7 the the DT cord-015306-us58wwmp 3480 8 FMF FMF NNP cord-015306-us58wwmp 3480 9 occurred occur VBD cord-015306-us58wwmp 3480 10 and and CC cord-015306-us58wwmp 3480 11 the the DT cord-015306-us58wwmp 3480 12 combination combination NN cord-015306-us58wwmp 3480 13 of of IN cord-015306-us58wwmp 3480 14 lowdose lowdose NNP cord-015306-us58wwmp 3480 15 colchicine colchicine NNP cord-015306-us58wwmp 3480 16 and and CC cord-015306-us58wwmp 3480 17 anakinra anakinra NNP cord-015306-us58wwmp 3480 18 improved improve VBD cord-015306-us58wwmp 3480 19 the the DT cord-015306-us58wwmp 3480 20 general general JJ cord-015306-us58wwmp 3480 21 status status NN cord-015306-us58wwmp 3480 22 of of IN cord-015306-us58wwmp 3480 23 the the DT cord-015306-us58wwmp 3480 24 patient patient NN cord-015306-us58wwmp 3480 25 The the DT cord-015306-us58wwmp 3480 26 elevated elevated JJ cord-015306-us58wwmp 3480 27 inflammatory inflammatory JJ cord-015306-us58wwmp 3480 28 parameters parameter NNS cord-015306-us58wwmp 3480 29 including include VBG cord-015306-us58wwmp 3480 30 serum serum NN cord-015306-us58wwmp 3480 31 amyloid amyloid NN cord-015306-us58wwmp 3480 32 A a DT cord-015306-us58wwmp 3480 33 have have VBP cord-015306-us58wwmp 3480 34 almost almost RB cord-015306-us58wwmp 3480 35 normalized normalize VBN cord-015306-us58wwmp 3480 36 . . . cord-015306-us58wwmp 3481 1 Objectives objective NNS cord-015306-us58wwmp 3481 2 : : : cord-015306-us58wwmp 3482 1 Invasive invasive JJ cord-015306-us58wwmp 3482 2 aspergillosis aspergillosis NN cord-015306-us58wwmp 3482 3 is be VBZ cord-015306-us58wwmp 3482 4 almost almost RB cord-015306-us58wwmp 3482 5 exclusively exclusively RB cord-015306-us58wwmp 3482 6 occurs occur VBZ cord-015306-us58wwmp 3482 7 in in IN cord-015306-us58wwmp 3482 8 immunocompromised immunocompromised JJ cord-015306-us58wwmp 3482 9 hosts host NNS cord-015306-us58wwmp 3482 10 . . . cord-015306-us58wwmp 3483 1 The the DT cord-015306-us58wwmp 3483 2 central central JJ cord-015306-us58wwmp 3483 3 nervous nervous JJ cord-015306-us58wwmp 3483 4 system system NN cord-015306-us58wwmp 3483 5 ( ( -LRB- cord-015306-us58wwmp 3483 6 CNS CNS NNP cord-015306-us58wwmp 3483 7 ) ) -RRB- cord-015306-us58wwmp 3483 8 is be VBZ cord-015306-us58wwmp 3483 9 one one CD cord-015306-us58wwmp 3483 10 of of IN cord-015306-us58wwmp 3483 11 the the DT cord-015306-us58wwmp 3483 12 most most RBS cord-015306-us58wwmp 3483 13 frequent frequent JJ cord-015306-us58wwmp 3483 14 sites site NNS cord-015306-us58wwmp 3483 15 of of IN cord-015306-us58wwmp 3483 16 invaziveaspergillozis invaziveaspergillozis NNP cord-015306-us58wwmp 3483 17 after after IN cord-015306-us58wwmp 3483 18 the the DT cord-015306-us58wwmp 3483 19 lungs lung NNS cord-015306-us58wwmp 3483 20 . . . cord-015306-us58wwmp 3484 1 We -PRON- PRP cord-015306-us58wwmp 3484 2 report report VBP cord-015306-us58wwmp 3484 3 a a DT cord-015306-us58wwmp 3484 4 case case NN cord-015306-us58wwmp 3484 5 of of IN cord-015306-us58wwmp 3484 6 invasive invasive JJ cord-015306-us58wwmp 3484 7 Aspergillosis Aspergillosis NNP cord-015306-us58wwmp 3484 8 in in IN cord-015306-us58wwmp 3484 9 a a DT cord-015306-us58wwmp 3484 10 boy boy NN cord-015306-us58wwmp 3484 11 with with IN cord-015306-us58wwmp 3484 12 end end NN cord-015306-us58wwmp 3484 13 stage stage NN cord-015306-us58wwmp 3484 14 renal renal JJ cord-015306-us58wwmp 3484 15 failure failure NN cord-015306-us58wwmp 3484 16 . . . cord-015306-us58wwmp 3485 1 Methods method NNS cord-015306-us58wwmp 3485 2 and and CC cord-015306-us58wwmp 3485 3 Results result NNS cord-015306-us58wwmp 3485 4 : : : cord-015306-us58wwmp 3485 5 A a DT cord-015306-us58wwmp 3485 6 15-year 15-year JJ cord-015306-us58wwmp 3485 7 - - HYPH cord-015306-us58wwmp 3485 8 old old JJ cord-015306-us58wwmp 3485 9 boy boy NN cord-015306-us58wwmp 3485 10 was be VBD cord-015306-us58wwmp 3485 11 admitted admit VBN cord-015306-us58wwmp 3485 12 to to IN cord-015306-us58wwmp 3485 13 the the DT cord-015306-us58wwmp 3485 14 hospital hospital NN cord-015306-us58wwmp 3485 15 for for IN cord-015306-us58wwmp 3485 16 abdominal abdominal JJ cord-015306-us58wwmp 3485 17 pain pain NN cord-015306-us58wwmp 3485 18 , , , cord-015306-us58wwmp 3485 19 fewer few JJR cord-015306-us58wwmp 3485 20 and and CC cord-015306-us58wwmp 3485 21 cough cough NN cord-015306-us58wwmp 3485 22 . . . cord-015306-us58wwmp 3486 1 He -PRON- PRP cord-015306-us58wwmp 3486 2 suffered suffer VBD cord-015306-us58wwmp 3486 3 from from IN cord-015306-us58wwmp 3486 4 chronic chronic JJ cord-015306-us58wwmp 3486 5 kidney kidney NN cord-015306-us58wwmp 3486 6 failure failure NN cord-015306-us58wwmp 3486 7 ( ( -LRB- cord-015306-us58wwmp 3486 8 CRF CRF NNP cord-015306-us58wwmp 3486 9 ) ) -RRB- cord-015306-us58wwmp 3486 10 known know VBN cord-015306-us58wwmp 3486 11 for for IN cord-015306-us58wwmp 3486 12 a a DT cord-015306-us58wwmp 3486 13 year year NN cord-015306-us58wwmp 3487 1 and and CC cord-015306-us58wwmp 3487 2 he -PRON- PRP cord-015306-us58wwmp 3487 3 was be VBD cord-015306-us58wwmp 3487 4 on on IN cord-015306-us58wwmp 3487 5 peritoneal peritoneal JJ cord-015306-us58wwmp 3487 6 dialysis dialysis NN cord-015306-us58wwmp 3487 7 for for IN cord-015306-us58wwmp 3487 8 seven seven CD cord-015306-us58wwmp 3487 9 months month NNS cord-015306-us58wwmp 3487 10 . . . cord-015306-us58wwmp 3488 1 He -PRON- PRP cord-015306-us58wwmp 3488 2 was be VBD cord-015306-us58wwmp 3488 3 initially initially RB cord-015306-us58wwmp 3488 4 treated treat VBN cord-015306-us58wwmp 3488 5 with with IN cord-015306-us58wwmp 3488 6 iv iv NNP cord-015306-us58wwmp 3488 7 . . . cord-015306-us58wwmp 3489 1 ceftriaxone ceftriaxone NNP cord-015306-us58wwmp 3489 2 for for IN cord-015306-us58wwmp 3489 3 lobar lobar NNP cord-015306-us58wwmp 3489 4 pneumonia pneumonia NN cord-015306-us58wwmp 3489 5 , , , cord-015306-us58wwmp 3489 6 intraperitonealceftazidime intraperitonealceftazidime NNP cord-015306-us58wwmp 3489 7 and and CC cord-015306-us58wwmp 3489 8 cefazolin cefazolin NNP cord-015306-us58wwmp 3489 9 for for IN cord-015306-us58wwmp 3489 10 peritonitis peritonitis NN cord-015306-us58wwmp 3489 11 . . . cord-015306-us58wwmp 3490 1 The the DT cord-015306-us58wwmp 3490 2 peritoneal peritoneal JJ cord-015306-us58wwmp 3490 3 fluid fluid NN cord-015306-us58wwmp 3490 4 was be VBD cord-015306-us58wwmp 3490 5 also also RB cord-015306-us58wwmp 3490 6 cultured culture VBN cord-015306-us58wwmp 3490 7 for for IN cord-015306-us58wwmp 3490 8 fungus fungus NN cord-015306-us58wwmp 3490 9 and and CC cord-015306-us58wwmp 3490 10 mycobacteria mycobacterium NNS cord-015306-us58wwmp 3490 11 and and CC cord-015306-us58wwmp 3490 12 all all DT cord-015306-us58wwmp 3490 13 cultures culture NNS cord-015306-us58wwmp 3490 14 were be VBD cord-015306-us58wwmp 3490 15 negative negative JJ cord-015306-us58wwmp 3490 16 . . . cord-015306-us58wwmp 3491 1 On on IN cord-015306-us58wwmp 3491 2 the the DT cord-015306-us58wwmp 3491 3 seventh seventh JJ cord-015306-us58wwmp 3491 4 day day NN cord-015306-us58wwmp 3491 5 , , , cord-015306-us58wwmp 3491 6 the the DT cord-015306-us58wwmp 3491 7 patient patient NN cord-015306-us58wwmp 3491 8 complained complain VBD cord-015306-us58wwmp 3491 9 for for IN cord-015306-us58wwmp 3491 10 lower low JJR cord-015306-us58wwmp 3491 11 extremity extremity NN cord-015306-us58wwmp 3491 12 weakness weakness NN cord-015306-us58wwmp 3491 13 , , , cord-015306-us58wwmp 3491 14 and and CC cord-015306-us58wwmp 3491 15 bilateral bilateral JJ cord-015306-us58wwmp 3491 16 hyperactive hyperactive JJ cord-015306-us58wwmp 3491 17 deep deep JJ cord-015306-us58wwmp 3491 18 tendon tendon NN cord-015306-us58wwmp 3491 19 reflexes reflex NNS cord-015306-us58wwmp 3491 20 and and CC cord-015306-us58wwmp 3491 21 positive positive JJ cord-015306-us58wwmp 3491 22 babinski babinski NNP cord-015306-us58wwmp 3491 23 reflex reflex NN cord-015306-us58wwmp 3491 24 were be VBD cord-015306-us58wwmp 3491 25 found find VBN cord-015306-us58wwmp 3491 26 . . . cord-015306-us58wwmp 3492 1 Cranial cranial JJ cord-015306-us58wwmp 3492 2 magnetic magnetic JJ cord-015306-us58wwmp 3492 3 resonance resonance NN cord-015306-us58wwmp 3492 4 imaging imaging NN cord-015306-us58wwmp 3492 5 ( ( -LRB- cord-015306-us58wwmp 3492 6 MRI MRI NNP cord-015306-us58wwmp 3492 7 ) ) -RRB- cord-015306-us58wwmp 3492 8 was be VBD cord-015306-us58wwmp 3492 9 normal normal JJ cord-015306-us58wwmp 3492 10 , , , cord-015306-us58wwmp 3492 11 but but CC cord-015306-us58wwmp 3492 12 the the DT cord-015306-us58wwmp 3492 13 spinal spinal JJ cord-015306-us58wwmp 3492 14 cord cord NN cord-015306-us58wwmp 3492 15 was be VBD cord-015306-us58wwmp 3492 16 compressed compress VBN cord-015306-us58wwmp 3492 17 between between IN cord-015306-us58wwmp 3492 18 C7-T5 c7-t5 NN cord-015306-us58wwmp 3492 19 by by IN cord-015306-us58wwmp 3492 20 a a DT cord-015306-us58wwmp 3492 21 solid solid JJ cord-015306-us58wwmp 3492 22 mass mass NN cord-015306-us58wwmp 3492 23 which which WDT cord-015306-us58wwmp 3492 24 was be VBD cord-015306-us58wwmp 3492 25 originated originate VBN cord-015306-us58wwmp 3492 26 from from IN cord-015306-us58wwmp 3492 27 right right JJ cord-015306-us58wwmp 3492 28 lung lung NN cord-015306-us58wwmp 3492 29 on on IN cord-015306-us58wwmp 3492 30 spinal spinal JJ cord-015306-us58wwmp 3492 31 MRI MRI NNP cord-015306-us58wwmp 3492 32 . . . cord-015306-us58wwmp 3493 1 Computed compute VBN cord-015306-us58wwmp 3493 2 tomography tomography NN cord-015306-us58wwmp 3493 3 - - HYPH cord-015306-us58wwmp 3493 4 guided guide VBN cord-015306-us58wwmp 3493 5 tru tru NN cord-015306-us58wwmp 3493 6 - - HYPH cord-015306-us58wwmp 3493 7 cut cut JJ cord-015306-us58wwmp 3493 8 lung lung NN cord-015306-us58wwmp 3493 9 biopsy biopsy NN cord-015306-us58wwmp 3493 10 was be VBD cord-015306-us58wwmp 3493 11 performed perform VBN cord-015306-us58wwmp 3493 12 for for IN cord-015306-us58wwmp 3493 13 the the DT cord-015306-us58wwmp 3493 14 solid solid JJ cord-015306-us58wwmp 3493 15 mass mass NN cord-015306-us58wwmp 3493 16 . . . cord-015306-us58wwmp 3494 1 Repeated repeat VBN cord-015306-us58wwmp 3494 2 peritoneal peritoneal JJ cord-015306-us58wwmp 3494 3 fluid fluid JJ cord-015306-us58wwmp 3494 4 culteres cultere NNS cord-015306-us58wwmp 3494 5 were be VBD cord-015306-us58wwmp 3494 6 also also RB cord-015306-us58wwmp 3494 7 negative negative JJ cord-015306-us58wwmp 3494 8 . . . cord-015306-us58wwmp 3495 1 Two two CD cord-015306-us58wwmp 3495 2 days day NNS cord-015306-us58wwmp 3495 3 later later RB cord-015306-us58wwmp 3495 4 , , , cord-015306-us58wwmp 3495 5 when when WRB cord-015306-us58wwmp 3495 6 unconsiousness unconsiousness NN cord-015306-us58wwmp 3495 7 and and CC cord-015306-us58wwmp 3495 8 convulsions convulsion NNS cord-015306-us58wwmp 3495 9 were be VBD cord-015306-us58wwmp 3495 10 seen see VBN cord-015306-us58wwmp 3495 11 , , , cord-015306-us58wwmp 3495 12 intraparenchymal intraparenchymal JJ cord-015306-us58wwmp 3495 13 multiple multiple JJ cord-015306-us58wwmp 3495 14 hemorrhagic hemorrhagic JJ cord-015306-us58wwmp 3495 15 abscesses abscess NNS cord-015306-us58wwmp 3495 16 were be VBD cord-015306-us58wwmp 3495 17 found find VBN cord-015306-us58wwmp 3495 18 on on IN cord-015306-us58wwmp 3495 19 his -PRON- PRP$ cord-015306-us58wwmp 3495 20 second second JJ cord-015306-us58wwmp 3495 21 MRI MRI NNP cord-015306-us58wwmp 3495 22 . . . cord-015306-us58wwmp 3496 1 Typical typical JJ cord-015306-us58wwmp 3496 2 hyphae hypha NNS cord-015306-us58wwmp 3496 3 of of IN cord-015306-us58wwmp 3496 4 aspergillusfumigatus aspergillusfumigatus NNP cord-015306-us58wwmp 3496 5 was be VBD cord-015306-us58wwmp 3496 6 present present JJ cord-015306-us58wwmp 3496 7 in in IN cord-015306-us58wwmp 3496 8 pathologic pathologic JJ cord-015306-us58wwmp 3496 9 specimens specimen NNS cord-015306-us58wwmp 3496 10 and and CC cord-015306-us58wwmp 3496 11 galactomannan galactomannan NNP cord-015306-us58wwmp 3496 12 test test NN cord-015306-us58wwmp 3496 13 was be VBD cord-015306-us58wwmp 3496 14 positive positive JJ cord-015306-us58wwmp 3496 15 . . . cord-015306-us58wwmp 3497 1 Cerebral cerebral JJ cord-015306-us58wwmp 3497 2 abscesses abscess NNS cord-015306-us58wwmp 3497 3 were be VBD cord-015306-us58wwmp 3497 4 evaluated evaluate VBN cord-015306-us58wwmp 3497 5 as as IN cord-015306-us58wwmp 3497 6 CNS CNS NNP cord-015306-us58wwmp 3497 7 involvement involvement NN cord-015306-us58wwmp 3497 8 of of IN cord-015306-us58wwmp 3497 9 invasive invasive JJ cord-015306-us58wwmp 3497 10 aspergillosis aspergillosis NN cord-015306-us58wwmp 3497 11 . . . cord-015306-us58wwmp 3498 1 Anti anti JJ cord-015306-us58wwmp 3498 2 fungal fungal JJ cord-015306-us58wwmp 3498 3 therapy therapy NN cord-015306-us58wwmp 3498 4 was be VBD cord-015306-us58wwmp 3498 5 began begin VBN cord-015306-us58wwmp 3498 6 immediately immediately RB cord-015306-us58wwmp 3498 7 as as IN cord-015306-us58wwmp 3498 8 amphotericin amphotericin NNS cord-015306-us58wwmp 3498 9 B B NNP cord-015306-us58wwmp 3498 10 and and CC cord-015306-us58wwmp 3498 11 caspofungin caspofungin NNP cord-015306-us58wwmp 3498 12 . . . cord-015306-us58wwmp 3499 1 The the DT cord-015306-us58wwmp 3499 2 peritoneal peritoneal JJ cord-015306-us58wwmp 3499 3 catheter catheter NN cord-015306-us58wwmp 3499 4 was be VBD cord-015306-us58wwmp 3499 5 removed remove VBN cord-015306-us58wwmp 3499 6 and and CC cord-015306-us58wwmp 3499 7 continuous continuous JJ cord-015306-us58wwmp 3499 8 veno veno NNP cord-015306-us58wwmp 3499 9 - - HYPH cord-015306-us58wwmp 3499 10 venous venous JJ cord-015306-us58wwmp 3499 11 hemodiafiltration hemodiafiltration NN cord-015306-us58wwmp 3499 12 was be VBD cord-015306-us58wwmp 3499 13 performed perform VBN cord-015306-us58wwmp 3499 14 . . . cord-015306-us58wwmp 3500 1 However however RB cord-015306-us58wwmp 3500 2 his -PRON- PRP$ cord-015306-us58wwmp 3500 3 condition condition NN cord-015306-us58wwmp 3500 4 kept keep VBD cord-015306-us58wwmp 3500 5 deteriorating deteriorate VBG cord-015306-us58wwmp 3500 6 and and CC cord-015306-us58wwmp 3500 7 death death NN cord-015306-us58wwmp 3500 8 ensued ensue VBD cord-015306-us58wwmp 3500 9 on on IN cord-015306-us58wwmp 3500 10 the the DT cord-015306-us58wwmp 3500 11 fourth fourth JJ cord-015306-us58wwmp 3500 12 day day NN cord-015306-us58wwmp 3500 13 of of IN cord-015306-us58wwmp 3500 14 anti anti JJ cord-015306-us58wwmp 3500 15 fungal fungal JJ cord-015306-us58wwmp 3500 16 therapy therapy NN cord-015306-us58wwmp 3500 17 . . . cord-015306-us58wwmp 3501 1 Conclusion conclusion NN cord-015306-us58wwmp 3501 2 : : : cord-015306-us58wwmp 3502 1 Invasive invasive JJ cord-015306-us58wwmp 3502 2 Aspergillosis Aspergillosis NNP cord-015306-us58wwmp 3502 3 may may MD cord-015306-us58wwmp 3502 4 rarely rarely RB cord-015306-us58wwmp 3502 5 occur occur VB cord-015306-us58wwmp 3502 6 in in IN cord-015306-us58wwmp 3502 7 immunocompetent immunocompetent JJ cord-015306-us58wwmp 3502 8 patients patient NNS cord-015306-us58wwmp 3502 9 and and CC cord-015306-us58wwmp 3502 10 diagnosis diagnosis NN cord-015306-us58wwmp 3502 11 may may MD cord-015306-us58wwmp 3502 12 be be VB cord-015306-us58wwmp 3502 13 missed miss VBN cord-015306-us58wwmp 3502 14 or or CC cord-015306-us58wwmp 3502 15 delayed delay VBN cord-015306-us58wwmp 3502 16 due due IN cord-015306-us58wwmp 3502 17 to to IN cord-015306-us58wwmp 3502 18 lack lack NN cord-015306-us58wwmp 3502 19 of of IN cord-015306-us58wwmp 3502 20 the the DT cord-015306-us58wwmp 3502 21 particular particular JJ cord-015306-us58wwmp 3502 22 clinical clinical JJ cord-015306-us58wwmp 3502 23 signs sign NNS cord-015306-us58wwmp 3502 24 . . . cord-015306-us58wwmp 3503 1 We -PRON- PRP cord-015306-us58wwmp 3503 2 should should MD cord-015306-us58wwmp 3503 3 be be VB cord-015306-us58wwmp 3503 4 careful careful JJ cord-015306-us58wwmp 3503 5 about about IN cord-015306-us58wwmp 3503 6 diagnosis diagnosis NN cord-015306-us58wwmp 3503 7 of of IN cord-015306-us58wwmp 3503 8 fungal fungal JJ cord-015306-us58wwmp 3503 9 infections infection NNS cord-015306-us58wwmp 3503 10 in in IN cord-015306-us58wwmp 3503 11 patients patient NNS cord-015306-us58wwmp 3503 12 with with IN cord-015306-us58wwmp 3503 13 CRF CRF NNP cord-015306-us58wwmp 3503 14 since since IN cord-015306-us58wwmp 3503 15 early early JJ cord-015306-us58wwmp 3503 16 treatment treatment NN cord-015306-us58wwmp 3503 17 before before IN cord-015306-us58wwmp 3503 18 the the DT cord-015306-us58wwmp 3503 19 invasion invasion NN cord-015306-us58wwmp 3503 20 and and CC cord-015306-us58wwmp 3503 21 dissemination dissemination NN cord-015306-us58wwmp 3503 22 of of IN cord-015306-us58wwmp 3503 23 aspergillosis aspergillosis NN cord-015306-us58wwmp 3503 24 to to TO cord-015306-us58wwmp 3503 25 adjacent adjacent JJ cord-015306-us58wwmp 3503 26 tissues tissue NNS cord-015306-us58wwmp 3504 1 and/or and/or CC cord-015306-us58wwmp 3504 2 organs organ NNS cord-015306-us58wwmp 3504 3 offers offer VBZ cord-015306-us58wwmp 3504 4 a a DT cord-015306-us58wwmp 3504 5 higher high JJR cord-015306-us58wwmp 3504 6 survival survival NN cord-015306-us58wwmp 3504 7 chance chance NN cord-015306-us58wwmp 3504 8 for for IN cord-015306-us58wwmp 3504 9 the the DT cord-015306-us58wwmp 3504 10 patient patient NN cord-015306-us58wwmp 3504 11 . . . cord-015306-us58wwmp 3505 1 questionnaire questionnaire NN cord-015306-us58wwmp 3505 2 and and CC cord-015306-us58wwmp 3505 3 to to TO cord-015306-us58wwmp 3505 4 find find VB cord-015306-us58wwmp 3505 5 a a DT cord-015306-us58wwmp 3505 6 way way NN cord-015306-us58wwmp 3505 7 to to TO cord-015306-us58wwmp 3505 8 increase increase VB cord-015306-us58wwmp 3505 9 reliability reliability NN cord-015306-us58wwmp 3505 10 for for IN cord-015306-us58wwmp 3505 11 healthy healthy JJ cord-015306-us58wwmp 3505 12 children child NNS cord-015306-us58wwmp 3505 13 aged age VBN cord-015306-us58wwmp 3505 14 8 8 CD cord-015306-us58wwmp 3505 15 - - SYM cord-015306-us58wwmp 3505 16 12 12 CD cord-015306-us58wwmp 3505 17 years year NNS cord-015306-us58wwmp 3505 18 especially especially RB cord-015306-us58wwmp 3505 19 , , , cord-015306-us58wwmp 3505 20 according accord VBG cord-015306-us58wwmp 3505 21 to to IN cord-015306-us58wwmp 3505 22 Iranian iranian JJ cord-015306-us58wwmp 3505 23 culture culture NN cord-015306-us58wwmp 3505 24 . . . cord-015306-us58wwmp 3506 1 Objective objective NN cord-015306-us58wwmp 3506 2 : : : cord-015306-us58wwmp 3507 1 We -PRON- PRP cord-015306-us58wwmp 3507 2 lunch lunch VBP cord-015306-us58wwmp 3507 3 this this DT cord-015306-us58wwmp 3507 4 study study NN cord-015306-us58wwmp 3507 5 to to TO cord-015306-us58wwmp 3507 6 compare compare VB cord-015306-us58wwmp 3507 7 the the DT cord-015306-us58wwmp 3507 8 parent parent NN cord-015306-us58wwmp 3507 9 and and CC cord-015306-us58wwmp 3507 10 children child NNS cord-015306-us58wwmp 3507 11 's 's POS cord-015306-us58wwmp 3507 12 behavior behavior NN cord-015306-us58wwmp 3507 13 problem problem NN cord-015306-us58wwmp 3507 14 in in IN cord-015306-us58wwmp 3507 15 pediatric pediatric JJ cord-015306-us58wwmp 3507 16 patients patient NNS cord-015306-us58wwmp 3507 17 suffering suffer VBG cord-015306-us58wwmp 3507 18 from from IN cord-015306-us58wwmp 3507 19 CKD CKD NNP cord-015306-us58wwmp 3507 20 referring refer VBG cord-015306-us58wwmp 3507 21 Arak Arak NNP cord-015306-us58wwmp 3507 22 Amir Amir NNP cord-015306-us58wwmp 3507 23 Kabir Kabir NNP cord-015306-us58wwmp 3507 24 Hospital Hospital NNP cord-015306-us58wwmp 3507 25 . . . cord-015306-us58wwmp 3508 1 Methods method NNS cord-015306-us58wwmp 3508 2 : : : cord-015306-us58wwmp 3508 3 To to TO cord-015306-us58wwmp 3508 4 perform perform VB cord-015306-us58wwmp 3508 5 this this DT cord-015306-us58wwmp 3508 6 case case NN cord-015306-us58wwmp 3508 7 control control NN cord-015306-us58wwmp 3508 8 study study NN cord-015306-us58wwmp 3508 9 , , , cord-015306-us58wwmp 3508 10 we -PRON- PRP cord-015306-us58wwmp 3508 11 recruit recruit VBP cord-015306-us58wwmp 3508 12 116 116 CD cord-015306-us58wwmp 3508 13 children child NNS cord-015306-us58wwmp 3508 14 with with IN cord-015306-us58wwmp 3508 15 CKD CKD NNP cord-015306-us58wwmp 3508 16 and and CC cord-015306-us58wwmp 3508 17 compared compare VBD cord-015306-us58wwmp 3508 18 them -PRON- PRP cord-015306-us58wwmp 3508 19 with with IN cord-015306-us58wwmp 3508 20 other other JJ cord-015306-us58wwmp 3508 21 116 116 CD cord-015306-us58wwmp 3508 22 non non JJ cord-015306-us58wwmp 3508 23 affected affected JJ cord-015306-us58wwmp 3508 24 children child NNS cord-015306-us58wwmp 3508 25 age age NN cord-015306-us58wwmp 3508 26 between between IN cord-015306-us58wwmp 3508 27 5 5 CD cord-015306-us58wwmp 3508 28 to to TO cord-015306-us58wwmp 3508 29 16 16 CD cord-015306-us58wwmp 3508 30 years year NNS cord-015306-us58wwmp 3508 31 old old JJ cord-015306-us58wwmp 3508 32 . . . cord-015306-us58wwmp 3509 1 The the DT cord-015306-us58wwmp 3509 2 child child NN cord-015306-us58wwmp 3509 3 behavior behavior NN cord-015306-us58wwmp 3509 4 checklist checklist NN cord-015306-us58wwmp 3509 5 CBCL4/18 CBCL4/18 NNP cord-015306-us58wwmp 3509 6 for for IN cord-015306-us58wwmp 3509 7 child child NN cord-015306-us58wwmp 3509 8 behavior behavior NN cord-015306-us58wwmp 3509 9 assessment assessment NN cord-015306-us58wwmp 3509 10 and and CC cord-015306-us58wwmp 3509 11 general general JJ cord-015306-us58wwmp 3509 12 assessment assessment NN cord-015306-us58wwmp 3509 13 function function NN cord-015306-us58wwmp 3509 14 GAF GAF NNP cord-015306-us58wwmp 3509 15 for for IN cord-015306-us58wwmp 3509 16 the the DT cord-015306-us58wwmp 3509 17 evaluation evaluation NN cord-015306-us58wwmp 3509 18 of of IN cord-015306-us58wwmp 3509 19 their -PRON- PRP$ cord-015306-us58wwmp 3509 20 parent parent NN cord-015306-us58wwmp 3509 21 's 's POS cord-015306-us58wwmp 3509 22 behavior behavior NN cord-015306-us58wwmp 3509 23 were be VBD cord-015306-us58wwmp 3509 24 completed complete VBN cord-015306-us58wwmp 3509 25 by by IN cord-015306-us58wwmp 3509 26 the the DT cord-015306-us58wwmp 3509 27 parent parent NN cord-015306-us58wwmp 3509 28 's 's POS cord-015306-us58wwmp 3509 29 data datum NNS cord-015306-us58wwmp 3509 30 was be VBD cord-015306-us58wwmp 3509 31 analyzed analyze VBN cord-015306-us58wwmp 3509 32 using use VBG cord-015306-us58wwmp 3509 33 qualitative qualitative JJ cord-015306-us58wwmp 3509 34 variables variable NNS cord-015306-us58wwmp 3509 35 and and CC cord-015306-us58wwmp 3509 36 chi chi JJ cord-015306-us58wwmp 3509 37 - - JJ cord-015306-us58wwmp 3509 38 square square JJ cord-015306-us58wwmp 3509 39 formula formula NN cord-015306-us58wwmp 3509 40 . . . cord-015306-us58wwmp 3510 1 Results result NNS cord-015306-us58wwmp 3510 2 : : : cord-015306-us58wwmp 3511 1 Among among IN cord-015306-us58wwmp 3511 2 116 116 CD cord-015306-us58wwmp 3511 3 patients patient NNS cord-015306-us58wwmp 3511 4 with with IN cord-015306-us58wwmp 3511 5 CKD CKD NNP cord-015306-us58wwmp 3511 6 , , , cord-015306-us58wwmp 3511 7 10 10 CD cord-015306-us58wwmp 3511 8 case case NN cord-015306-us58wwmp 3511 9 8.6 8.6 CD cord-015306-us58wwmp 3511 10 % % NN cord-015306-us58wwmp 3511 11 showed show VBD cord-015306-us58wwmp 3511 12 behavioral behavioral JJ cord-015306-us58wwmp 3511 13 problem problem NN cord-015306-us58wwmp 3511 14 while while IN cord-015306-us58wwmp 3511 15 this this DT cord-015306-us58wwmp 3511 16 figure figure NN cord-015306-us58wwmp 3511 17 was be VBD cord-015306-us58wwmp 3511 18 3 3 CD cord-015306-us58wwmp 3511 19 case case NN cord-015306-us58wwmp 3511 20 2.6 2.6 CD cord-015306-us58wwmp 3511 21 % % NN cord-015306-us58wwmp 3511 22 in in IN cord-015306-us58wwmp 3511 23 the the DT cord-015306-us58wwmp 3511 24 control control NN cord-015306-us58wwmp 3511 25 group group NN cord-015306-us58wwmp 3511 26 , , , cord-015306-us58wwmp 3511 27 denoting denote VBG cord-015306-us58wwmp 3511 28 a a DT cord-015306-us58wwmp 3511 29 significant significant JJ cord-015306-us58wwmp 3511 30 difference difference NN cord-015306-us58wwmp 3511 31 P-0.04 p-0.04 NN cord-015306-us58wwmp 3511 32 . . . cord-015306-us58wwmp 3512 1 Moreover moreover RB cord-015306-us58wwmp 3512 2 20 20 CD cord-015306-us58wwmp 3512 3 children child NNS cord-015306-us58wwmp 3512 4 17/2 17/2 CD cord-015306-us58wwmp 3512 5 % % NN cord-015306-us58wwmp 3512 6 in in IN cord-015306-us58wwmp 3512 7 the the DT cord-015306-us58wwmp 3512 8 case case NN cord-015306-us58wwmp 3512 9 group group NN cord-015306-us58wwmp 3512 10 and and CC cord-015306-us58wwmp 3512 11 9 9 CD cord-015306-us58wwmp 3512 12 children child NNS cord-015306-us58wwmp 3512 13 7.8 7.8 CD cord-015306-us58wwmp 3512 14 % % NN cord-015306-us58wwmp 3512 15 in in IN cord-015306-us58wwmp 3512 16 the the DT cord-015306-us58wwmp 3512 17 control control NN cord-015306-us58wwmp 3512 18 group group NN cord-015306-us58wwmp 3512 19 had have VBD cord-015306-us58wwmp 3512 20 internalizing internalize VBG cord-015306-us58wwmp 3512 21 problem problem NN cord-015306-us58wwmp 3512 22 P-0.02 P-0.02 NNP cord-015306-us58wwmp 3512 23 . . . cord-015306-us58wwmp 3513 1 22 22 CD cord-015306-us58wwmp 3513 2 children child NNS cord-015306-us58wwmp 3513 3 19 19 CD cord-015306-us58wwmp 3513 4 % % NN cord-015306-us58wwmp 3513 5 with with IN cord-015306-us58wwmp 3513 6 CKD CKD NNP cord-015306-us58wwmp 3513 7 and and CC cord-015306-us58wwmp 3513 8 8 8 CD cord-015306-us58wwmp 3513 9 children child NNS cord-015306-us58wwmp 3513 10 6.9 6.9 CD cord-015306-us58wwmp 3513 11 % % NN cord-015306-us58wwmp 3513 12 in in IN cord-015306-us58wwmp 3513 13 the the DT cord-015306-us58wwmp 3513 14 healthy healthy JJ cord-015306-us58wwmp 3513 15 group group NN cord-015306-us58wwmp 3513 16 had have VBD cord-015306-us58wwmp 3513 17 externalizing externalize VBG cord-015306-us58wwmp 3513 18 problem problem NN cord-015306-us58wwmp 3513 19 which which WDT cord-015306-us58wwmp 3513 20 was be VBD cord-015306-us58wwmp 3513 21 also also RB cord-015306-us58wwmp 3513 22 a a DT cord-015306-us58wwmp 3513 23 significant significant JJ cord-015306-us58wwmp 3513 24 difference difference NN cord-015306-us58wwmp 3513 25 P-0.0003 P-0.0003 NNP cord-015306-us58wwmp 3513 26 . . . cord-015306-us58wwmp 3514 1 As as IN cord-015306-us58wwmp 3514 2 a a DT cord-015306-us58wwmp 3514 3 significant significant JJ cord-015306-us58wwmp 3514 4 P-0.0001 P-0.0001 NNP cord-015306-us58wwmp 3514 5 the the DT cord-015306-us58wwmp 3514 6 parent parent NN cord-015306-us58wwmp 3514 7 's 's POS cord-015306-us58wwmp 3514 8 average average JJ cord-015306-us58wwmp 3514 9 stress stress NN cord-015306-us58wwmp 3514 10 and and CC cord-015306-us58wwmp 3514 11 behavior behavior NN cord-015306-us58wwmp 3514 12 scores score NNS cord-015306-us58wwmp 3514 13 in in IN cord-015306-us58wwmp 3514 14 case case NN cord-015306-us58wwmp 3514 15 and and CC cord-015306-us58wwmp 3514 16 control control NN cord-015306-us58wwmp 3514 17 were be VBD cord-015306-us58wwmp 3514 18 3.65 3.65 CD cord-015306-us58wwmp 3514 19 & & CC cord-015306-us58wwmp 3514 20 3.76 3.76 CD cord-015306-us58wwmp 3514 21 , , , cord-015306-us58wwmp 3514 22 respectively respectively RB cord-015306-us58wwmp 3514 23 . . . cord-015306-us58wwmp 3515 1 Conclusion conclusion NN cord-015306-us58wwmp 3515 2 : : : cord-015306-us58wwmp 3516 1 The the DT cord-015306-us58wwmp 3516 2 higher high JJR cord-015306-us58wwmp 3516 3 prevalence prevalence NN cord-015306-us58wwmp 3516 4 of of IN cord-015306-us58wwmp 3516 5 behavioral behavioral JJ cord-015306-us58wwmp 3516 6 problem problem NN cord-015306-us58wwmp 3516 7 in in IN cord-015306-us58wwmp 3516 8 the the DT cord-015306-us58wwmp 3516 9 children child NNS cord-015306-us58wwmp 3516 10 suffering suffer VBG cord-015306-us58wwmp 3516 11 from from IN cord-015306-us58wwmp 3516 12 CKD CKD NNP cord-015306-us58wwmp 3516 13 and and CC cord-015306-us58wwmp 3516 14 their -PRON- PRP$ cord-015306-us58wwmp 3516 15 parent parent NN cord-015306-us58wwmp 3516 16 's 's POS cord-015306-us58wwmp 3516 17 functional functional JJ cord-015306-us58wwmp 3516 18 impairment impairment NN cord-015306-us58wwmp 3516 19 highlights highlight VBZ cord-015306-us58wwmp 3516 20 the the DT cord-015306-us58wwmp 3516 21 important important JJ cord-015306-us58wwmp 3516 22 of of IN cord-015306-us58wwmp 3516 23 early early JJ cord-015306-us58wwmp 3516 24 treatment treatment NN cord-015306-us58wwmp 3516 25 and and CC cord-015306-us58wwmp 3516 26 subsequently subsequently RB cord-015306-us58wwmp 3516 27 prevention prevention NN cord-015306-us58wwmp 3516 28 of of IN cord-015306-us58wwmp 3516 29 future future JJ cord-015306-us58wwmp 3516 30 behavioral behavioral JJ cord-015306-us58wwmp 3516 31 problem problem NN cord-015306-us58wwmp 3516 32 in in IN cord-015306-us58wwmp 3516 33 their -PRON- PRP$ cord-015306-us58wwmp 3516 34 sibling sibling NN cord-015306-us58wwmp 3516 35 . . . cord-015306-us58wwmp 3517 1 Abstract abstract JJ cord-015306-us58wwmp 3517 2 # # NN cord-015306-us58wwmp 3517 3 P p NN cord-015306-us58wwmp 3517 4 - - HYPH cord-015306-us58wwmp 3517 5 SAT391 SAT391 NNP cord-015306-us58wwmp 3517 6 Development Development NNP cord-015306-us58wwmp 3517 7 in in IN cord-015306-us58wwmp 3517 8 6-year 6-year JJ cord-015306-us58wwmp 3517 9 - - HYPH cord-015306-us58wwmp 3517 10 old old JJ cord-015306-us58wwmp 3517 11 children child NNS cord-015306-us58wwmp 3517 12 with with IN cord-015306-us58wwmp 3517 13 and and CC cord-015306-us58wwmp 3517 14 without without IN cord-015306-us58wwmp 3517 15 CKD CKD NNP cord-015306-us58wwmp 3517 16 Objective Objective NNP cord-015306-us58wwmp 3517 17 : : : cord-015306-us58wwmp 3517 18 CKD CKD NNP cord-015306-us58wwmp 3517 19 is be VBZ cord-015306-us58wwmp 3517 20 a a DT cord-015306-us58wwmp 3517 21 pathophysiologic pathophysiologic JJ cord-015306-us58wwmp 3517 22 process process NN cord-015306-us58wwmp 3517 23 with with IN cord-015306-us58wwmp 3517 24 multiple multiple JJ cord-015306-us58wwmp 3517 25 etiologies etiology NNS cord-015306-us58wwmp 3517 26 , , , cord-015306-us58wwmp 3517 27 resulting result VBG cord-015306-us58wwmp 3517 28 in in IN cord-015306-us58wwmp 3517 29 the the DT cord-015306-us58wwmp 3517 30 inexorable inexorable JJ cord-015306-us58wwmp 3517 31 attrition attrition NN cord-015306-us58wwmp 3517 32 of of IN cord-015306-us58wwmp 3517 33 nephron nephron NN cord-015306-us58wwmp 3517 34 number number NN cord-015306-us58wwmp 3517 35 and and CC cord-015306-us58wwmp 3517 36 function function NN cord-015306-us58wwmp 3517 37 and and CC cord-015306-us58wwmp 3517 38 frequently frequently RB cord-015306-us58wwmp 3517 39 leading lead VBG cord-015306-us58wwmp 3517 40 to to IN cord-015306-us58wwmp 3517 41 ESRD ESRD NNP cord-015306-us58wwmp 3517 42 . . . cord-015306-us58wwmp 3518 1 A a DT cord-015306-us58wwmp 3518 2 number number NN cord-015306-us58wwmp 3518 3 of of IN cord-015306-us58wwmp 3518 4 studies study NNS cord-015306-us58wwmp 3518 5 have have VBP cord-015306-us58wwmp 3518 6 suggested suggest VBN cord-015306-us58wwmp 3518 7 that that IN cord-015306-us58wwmp 3518 8 children child NNS cord-015306-us58wwmp 3518 9 with with IN cord-015306-us58wwmp 3518 10 CKD CKD NNP cord-015306-us58wwmp 3518 11 have have VBP cord-015306-us58wwmp 3518 12 problem problem NN cord-015306-us58wwmp 3518 13 in in IN cord-015306-us58wwmp 3518 14 development development NN cord-015306-us58wwmp 3518 15 than than IN cord-015306-us58wwmp 3518 16 other other JJ cord-015306-us58wwmp 3518 17 children child NNS cord-015306-us58wwmp 3518 18 our -PRON- PRP$ cord-015306-us58wwmp 3518 19 goal goal NN cord-015306-us58wwmp 3518 20 was be VBD cord-015306-us58wwmp 3518 21 to to TO cord-015306-us58wwmp 3518 22 compare compare VB cord-015306-us58wwmp 3518 23 development development NN cord-015306-us58wwmp 3518 24 of of IN cord-015306-us58wwmp 3518 25 children child NNS cord-015306-us58wwmp 3518 26 with with IN cord-015306-us58wwmp 3518 27 CKD CKD NNP cord-015306-us58wwmp 3518 28 with with IN cord-015306-us58wwmp 3518 29 normal normal JJ cord-015306-us58wwmp 3518 30 children child NNS cord-015306-us58wwmp 3518 31 within within IN cord-015306-us58wwmp 3518 32 the the DT cord-015306-us58wwmp 3518 33 common common JJ cord-015306-us58wwmp 3518 34 age age NN cord-015306-us58wwmp 3518 35 range range NN cord-015306-us58wwmp 3518 36 for for IN cord-015306-us58wwmp 3518 37 the the DT cord-015306-us58wwmp 3518 38 disease disease NN cord-015306-us58wwmp 3518 39 . . . cord-015306-us58wwmp 3519 1 Methods method NNS cord-015306-us58wwmp 3519 2 : : : cord-015306-us58wwmp 3519 3 In in IN cord-015306-us58wwmp 3519 4 this this DT cord-015306-us58wwmp 3519 5 descriptive descriptive JJ cord-015306-us58wwmp 3519 6 - - HYPH cord-015306-us58wwmp 3519 7 analytical analytical JJ cord-015306-us58wwmp 3519 8 study study NN cord-015306-us58wwmp 3519 9 , , , cord-015306-us58wwmp 3519 10 we -PRON- PRP cord-015306-us58wwmp 3519 11 selected select VBD cord-015306-us58wwmp 3519 12 30 30 CD cord-015306-us58wwmp 3519 13 children child NNS cord-015306-us58wwmp 3519 14 with with IN cord-015306-us58wwmp 3519 15 6-year 6-year JJ cord-015306-us58wwmp 3519 16 - - HYPH cord-015306-us58wwmp 3519 17 old old JJ cord-015306-us58wwmp 3519 18 children child NNS cord-015306-us58wwmp 3519 19 whom whom WP cord-015306-us58wwmp 3519 20 were be VBD cord-015306-us58wwmp 3519 21 diagnosed diagnose VBN cord-015306-us58wwmp 3519 22 with with IN cord-015306-us58wwmp 3519 23 CKD CKD NNP cord-015306-us58wwmp 3519 24 as as IN cord-015306-us58wwmp 3519 25 our -PRON- PRP$ cord-015306-us58wwmp 3519 26 case case NN cord-015306-us58wwmp 3519 27 group group NN cord-015306-us58wwmp 3519 28 and and CC cord-015306-us58wwmp 3519 29 studied study VBD cord-015306-us58wwmp 3519 30 their -PRON- PRP$ cord-015306-us58wwmp 3519 31 developmental developmental JJ cord-015306-us58wwmp 3519 32 status status NN cord-015306-us58wwmp 3519 33 by by IN cord-015306-us58wwmp 3519 34 ages age NNS cord-015306-us58wwmp 3519 35 and and CC cord-015306-us58wwmp 3519 36 stages stage NNS cord-015306-us58wwmp 3519 37 questionnaire questionnaire NN cord-015306-us58wwmp 3519 38 ( ( -LRB- cord-015306-us58wwmp 3519 39 ASQ ASQ NNP cord-015306-us58wwmp 3519 40 ) ) -RRB- cord-015306-us58wwmp 3519 41 . . . cord-015306-us58wwmp 3520 1 The the DT cord-015306-us58wwmp 3520 2 control control NN cord-015306-us58wwmp 3520 3 group group NN cord-015306-us58wwmp 3520 4 was be VBD cord-015306-us58wwmp 3520 5 selected select VBN cord-015306-us58wwmp 3520 6 from from IN cord-015306-us58wwmp 3520 7 6-year 6-year JJ cord-015306-us58wwmp 3520 8 - - HYPH cord-015306-us58wwmp 3520 9 old old JJ cord-015306-us58wwmp 3520 10 children child NNS cord-015306-us58wwmp 3520 11 who who WP cord-015306-us58wwmp 3520 12 attended attend VBD cord-015306-us58wwmp 3520 13 the the DT cord-015306-us58wwmp 3520 14 clinic clinic NN cord-015306-us58wwmp 3520 15 for for IN cord-015306-us58wwmp 3520 16 reasons reason NNS cord-015306-us58wwmp 3520 17 other other JJ cord-015306-us58wwmp 3520 18 than than IN cord-015306-us58wwmp 3520 19 CKD CKD NNP cord-015306-us58wwmp 3520 20 . . . cord-015306-us58wwmp 3521 1 Conclusion Conclusion NNP cord-015306-us58wwmp 3521 2 & & CC cord-015306-us58wwmp 3521 3 Application Application NNP cord-015306-us58wwmp 3521 4 to to TO cord-015306-us58wwmp 3521 5 Practice practice VB cord-015306-us58wwmp 3521 6 : : : cord-015306-us58wwmp 3522 1 The the DT cord-015306-us58wwmp 3522 2 eleven eleven CD cord-015306-us58wwmp 3522 3 key key JJ cord-015306-us58wwmp 3522 4 areas area NNS cord-015306-us58wwmp 3522 5 of of IN cord-015306-us58wwmp 3522 6 responsibility responsibility NN cord-015306-us58wwmp 3522 7 used use VBN cord-015306-us58wwmp 3522 8 to to TO cord-015306-us58wwmp 3522 9 measure measure VB cord-015306-us58wwmp 3522 10 SC SC NNP cord-015306-us58wwmp 3522 11 in in IN cord-015306-us58wwmp 3522 12 a a DT cord-015306-us58wwmp 3522 13 periodic periodic JJ cord-015306-us58wwmp 3522 14 evaluation evaluation NN cord-015306-us58wwmp 3522 15 demonstrated demonstrate VBD cord-015306-us58wwmp 3522 16 a a DT cord-015306-us58wwmp 3522 17 strong strong JJ cord-015306-us58wwmp 3522 18 correlation correlation NN cord-015306-us58wwmp 3522 19 to to IN cord-015306-us58wwmp 3522 20 the the DT cord-015306-us58wwmp 3522 21 increasing increase VBG cord-015306-us58wwmp 3522 22 extent extent NN cord-015306-us58wwmp 3522 23 of of IN cord-015306-us58wwmp 3522 24 QPDO QPDO NNP cord-015306-us58wwmp 3522 25 . . . cord-015306-us58wwmp 3523 1 Additionally additionally RB cord-015306-us58wwmp 3523 2 , , , cord-015306-us58wwmp 3523 3 as as IN cord-015306-us58wwmp 3523 4 the the DT cord-015306-us58wwmp 3523 5 nurses nurse NNS cord-015306-us58wwmp 3523 6 progressed progress VBD cord-015306-us58wwmp 3523 7 to to IN cord-015306-us58wwmp 3523 8 becoming become VBG cord-015306-us58wwmp 3523 9 expert expert VB cord-015306-us58wwmp 3523 10 a a DT cord-015306-us58wwmp 3523 11 direct direct JJ cord-015306-us58wwmp 3523 12 correlation correlation NN cord-015306-us58wwmp 3523 13 to to IN cord-015306-us58wwmp 3523 14 the the DT cord-015306-us58wwmp 3523 15 QPDO QPDO NNP cord-015306-us58wwmp 3523 16 was be VBD cord-015306-us58wwmp 3523 17 notable notable JJ cord-015306-us58wwmp 3523 18 . . . cord-015306-us58wwmp 3524 1 The the DT cord-015306-us58wwmp 3524 2 study study NN cord-015306-us58wwmp 3524 3 became become VBD cord-015306-us58wwmp 3524 4 the the DT cord-015306-us58wwmp 3524 5 foundation foundation NN cord-015306-us58wwmp 3524 6 for for IN cord-015306-us58wwmp 3524 7 staff staff NN cord-015306-us58wwmp 3524 8 training training NN cord-015306-us58wwmp 3524 9 and and CC cord-015306-us58wwmp 3524 10 developing develop VBG cord-015306-us58wwmp 3524 11 a a DT cord-015306-us58wwmp 3524 12 competency competency NN cord-015306-us58wwmp 3524 13 appraisal appraisal NN cord-015306-us58wwmp 3524 14 framework framework NN cord-015306-us58wwmp 3524 15 in in IN cord-015306-us58wwmp 3524 16 renal renal JJ cord-015306-us58wwmp 3524 17 nursing nursing NN cord-015306-us58wwmp 3524 18 practice practice NN cord-015306-us58wwmp 3524 19 thereby thereby RB cord-015306-us58wwmp 3524 20 promoting promote VBG cord-015306-us58wwmp 3524 21 quality quality NN cord-015306-us58wwmp 3524 22 assurance assurance NN cord-015306-us58wwmp 3524 23 procedures procedure NNS cord-015306-us58wwmp 3524 24 while while IN cord-015306-us58wwmp 3524 25 attaining attain VBG cord-015306-us58wwmp 3524 26 QPDO QPDO NNP cord-015306-us58wwmp 3524 27 . . . cord-015306-us58wwmp 3525 1 Objective objective NN cord-015306-us58wwmp 3525 2 : : : cord-015306-us58wwmp 3526 1 Urinary urinary JJ cord-015306-us58wwmp 3526 2 incontinence incontinence NN cord-015306-us58wwmp 3526 3 is be VBZ cord-015306-us58wwmp 3526 4 a a DT cord-015306-us58wwmp 3526 5 child child NN cord-015306-us58wwmp 3526 6 health health NN cord-015306-us58wwmp 3526 7 problem problem NN cord-015306-us58wwmp 3526 8 that that WDT cord-015306-us58wwmp 3526 9 affect affect VBP cord-015306-us58wwmp 3526 10 both both CC cord-015306-us58wwmp 3526 11 the the DT cord-015306-us58wwmp 3526 12 child child NN cord-015306-us58wwmp 3526 13 and and CC cord-015306-us58wwmp 3526 14 the the DT cord-015306-us58wwmp 3526 15 family family NN cord-015306-us58wwmp 3526 16 in in IN cord-015306-us58wwmp 3526 17 psychological psychological JJ cord-015306-us58wwmp 3526 18 and and CC cord-015306-us58wwmp 3526 19 social social JJ cord-015306-us58wwmp 3526 20 aspect aspect NN cord-015306-us58wwmp 3526 21 and and CC cord-015306-us58wwmp 3526 22 that that DT cord-015306-us58wwmp 3526 23 leads lead VBZ cord-015306-us58wwmp 3526 24 to to IN cord-015306-us58wwmp 3526 25 a a DT cord-015306-us58wwmp 3526 26 decrease decrease NN cord-015306-us58wwmp 3526 27 in in IN cord-015306-us58wwmp 3526 28 quality quality NN cord-015306-us58wwmp 3526 29 of of IN cord-015306-us58wwmp 3526 30 life life NN cord-015306-us58wwmp 3526 31 of of IN cord-015306-us58wwmp 3526 32 the the DT cord-015306-us58wwmp 3526 33 child child NN cord-015306-us58wwmp 3526 34 and and CC cord-015306-us58wwmp 3526 35 his -PRON- PRP$ cord-015306-us58wwmp 3526 36 caregiver caregiver NN cord-015306-us58wwmp 3526 37 . . . cord-015306-us58wwmp 3527 1 Patients patient NNS cord-015306-us58wwmp 3527 2 with with IN cord-015306-us58wwmp 3527 3 higher high JJR cord-015306-us58wwmp 3527 4 CKD CKD NNP cord-015306-us58wwmp 3527 5 stage stage NN cord-015306-us58wwmp 3527 6 had have VBD cord-015306-us58wwmp 3527 7 significantly significantly RB cord-015306-us58wwmp 3527 8 lower low JJR cord-015306-us58wwmp 3527 9 QOL QOL NNP cord-015306-us58wwmp 3527 10 score score NN cord-015306-us58wwmp 3527 11 in in IN cord-015306-us58wwmp 3527 12 all all DT cord-015306-us58wwmp 3527 13 domains domain NNS cord-015306-us58wwmp 3527 14 in in IN cord-015306-us58wwmp 3527 15 the the DT cord-015306-us58wwmp 3527 16 child child NN cord-015306-us58wwmp 3527 17 - - HYPH cord-015306-us58wwmp 3527 18 self self NN cord-015306-us58wwmp 3527 19 reports report NNS cord-015306-us58wwmp 3527 20 , , , cord-015306-us58wwmp 3527 21 but but CC cord-015306-us58wwmp 3527 22 not not RB cord-015306-us58wwmp 3527 23 parent parent NN cord-015306-us58wwmp 3527 24 - - HYPH cord-015306-us58wwmp 3527 25 proxy proxy NN cord-015306-us58wwmp 3527 26 reports report NNS cord-015306-us58wwmp 3527 27 . . . cord-015306-us58wwmp 3528 1 Whereas whereas IN cord-015306-us58wwmp 3528 2 there there EX cord-015306-us58wwmp 3528 3 was be VBD cord-015306-us58wwmp 3528 4 no no DT cord-015306-us58wwmp 3528 5 difference difference NN cord-015306-us58wwmp 3528 6 between between IN cord-015306-us58wwmp 3528 7 patents patent NNS cord-015306-us58wwmp 3528 8 with with IN cord-015306-us58wwmp 3528 9 stage stage NN cord-015306-us58wwmp 3528 10 I -PRON- PRP cord-015306-us58wwmp 3528 11 and and CC cord-015306-us58wwmp 3528 12 stage stage NN cord-015306-us58wwmp 3528 13 II II NNP cord-015306-us58wwmp 3528 14 . . . cord-015306-us58wwmp 3529 1 According accord VBG cord-015306-us58wwmp 3529 2 to to IN cord-015306-us58wwmp 3529 3 gender gender NN cord-015306-us58wwmp 3529 4 , , , cord-015306-us58wwmp 3529 5 boys boy NNS cord-015306-us58wwmp 3529 6 had have VBD cord-015306-us58wwmp 3529 7 a a DT cord-015306-us58wwmp 3529 8 tendency tendency NN cord-015306-us58wwmp 3529 9 to to TO cord-015306-us58wwmp 3529 10 present present VB cord-015306-us58wwmp 3529 11 better well JJR cord-015306-us58wwmp 3529 12 QOL QOL NNP cord-015306-us58wwmp 3529 13 than than IN cord-015306-us58wwmp 3529 14 girls girl NNS cord-015306-us58wwmp 3529 15 , , , cord-015306-us58wwmp 3529 16 but but CC cord-015306-us58wwmp 3529 17 there there EX cord-015306-us58wwmp 3529 18 was be VBD cord-015306-us58wwmp 3529 19 no no DT cord-015306-us58wwmp 3529 20 significant significant JJ cord-015306-us58wwmp 3529 21 difference difference NN cord-015306-us58wwmp 3529 22 between between IN cord-015306-us58wwmp 3529 23 these these DT cord-015306-us58wwmp 3529 24 two two CD cord-015306-us58wwmp 3529 25 groups group NNS cord-015306-us58wwmp 3529 26 . . . cord-015306-us58wwmp 3530 1 Age age NN cord-015306-us58wwmp 3530 2 discrepancy discrepancy NN cord-015306-us58wwmp 3530 3 was be VBD cord-015306-us58wwmp 3530 4 not not RB cord-015306-us58wwmp 3530 5 a a DT cord-015306-us58wwmp 3530 6 significant significant JJ cord-015306-us58wwmp 3530 7 factor factor NN cord-015306-us58wwmp 3530 8 to to TO cord-015306-us58wwmp 3530 9 decide decide VB cord-015306-us58wwmp 3530 10 QOL QOL NNP cord-015306-us58wwmp 3530 11 in in IN cord-015306-us58wwmp 3530 12 children child NNS cord-015306-us58wwmp 3530 13 with with IN cord-015306-us58wwmp 3530 14 CKD CKD NNP cord-015306-us58wwmp 3530 15 . . . cord-015306-us58wwmp 3531 1 In in IN cord-015306-us58wwmp 3531 2 addition addition NN cord-015306-us58wwmp 3531 3 , , , cord-015306-us58wwmp 3531 4 there there EX cord-015306-us58wwmp 3531 5 was be VBD cord-015306-us58wwmp 3531 6 significant significant JJ cord-015306-us58wwmp 3531 7 difference difference NN cord-015306-us58wwmp 3531 8 between between IN cord-015306-us58wwmp 3531 9 parent parent NN cord-015306-us58wwmp 3531 10 - - HYPH cord-015306-us58wwmp 3531 11 proxy proxy NN cord-015306-us58wwmp 3531 12 reports report NNS cord-015306-us58wwmp 3531 13 and and CC cord-015306-us58wwmp 3531 14 child child NN cord-015306-us58wwmp 3531 15 - - HYPH cord-015306-us58wwmp 3531 16 self self NN cord-015306-us58wwmp 3531 17 reports report NNS cord-015306-us58wwmp 3531 18 and and CC cord-015306-us58wwmp 3531 19 QOL QOL NNP cord-015306-us58wwmp 3531 20 scores score NNS cord-015306-us58wwmp 3531 21 in in IN cord-015306-us58wwmp 3531 22 the the DT cord-015306-us58wwmp 3531 23 child child NN cord-015306-us58wwmp 3531 24 - - HYPH cord-015306-us58wwmp 3531 25 self self NN cord-015306-us58wwmp 3531 26 reports report NNS cord-015306-us58wwmp 3531 27 was be VBD cord-015306-us58wwmp 3531 28 significantly significantly RB cord-015306-us58wwmp 3531 29 higher high JJR cord-015306-us58wwmp 3531 30 than than IN cord-015306-us58wwmp 3531 31 in in IN cord-015306-us58wwmp 3531 32 the the DT cord-015306-us58wwmp 3531 33 parent parent NN cord-015306-us58wwmp 3531 34 - - HYPH cord-015306-us58wwmp 3531 35 proxy proxy NN cord-015306-us58wwmp 3531 36 reports report NNS cord-015306-us58wwmp 3531 37 , , , cord-015306-us58wwmp 3531 38 especially especially RB cord-015306-us58wwmp 3531 39 in in IN cord-015306-us58wwmp 3531 40 the the DT cord-015306-us58wwmp 3531 41 domains domain NNS cord-015306-us58wwmp 3531 42 of of IN cord-015306-us58wwmp 3531 43 emotional emotional JJ cord-015306-us58wwmp 3531 44 , , , cord-015306-us58wwmp 3531 45 school school NN cord-015306-us58wwmp 3531 46 functioning functioning NN cord-015306-us58wwmp 3531 47 and and CC cord-015306-us58wwmp 3531 48 psychosocial psychosocial JJ cord-015306-us58wwmp 3531 49 health health NN cord-015306-us58wwmp 3531 50 score score NN cord-015306-us58wwmp 3531 51 . . . cord-015306-us58wwmp 3532 1 Conclusion conclusion NN cord-015306-us58wwmp 3532 2 : : : cord-015306-us58wwmp 3533 1 Residual residual JJ cord-015306-us58wwmp 3533 2 renal renal JJ cord-015306-us58wwmp 3533 3 function function NN cord-015306-us58wwmp 3533 4 in in IN cord-015306-us58wwmp 3533 5 children child NNS cord-015306-us58wwmp 3533 6 with with IN cord-015306-us58wwmp 3533 7 CKD CKD NNP cord-015306-us58wwmp 3533 8 is be VBZ cord-015306-us58wwmp 3533 9 a a DT cord-015306-us58wwmp 3533 10 important important JJ cord-015306-us58wwmp 3533 11 factor factor NN cord-015306-us58wwmp 3533 12 to to TO cord-015306-us58wwmp 3533 13 decide decide VB cord-015306-us58wwmp 3533 14 QOL QOL NNP cord-015306-us58wwmp 3533 15 . . . cord-015306-us58wwmp 3534 1 In in IN cord-015306-us58wwmp 3534 2 addition addition NN cord-015306-us58wwmp 3534 3 , , , cord-015306-us58wwmp 3534 4 emotional emotional JJ cord-015306-us58wwmp 3534 5 and and CC cord-015306-us58wwmp 3534 6 psychosocial psychosocial JJ cord-015306-us58wwmp 3534 7 support support NN cord-015306-us58wwmp 3534 8 for for IN cord-015306-us58wwmp 3534 9 their -PRON- PRP$ cord-015306-us58wwmp 3534 10 parents parent NNS cord-015306-us58wwmp 3534 11 can can MD cord-015306-us58wwmp 3534 12 be be VB cord-015306-us58wwmp 3534 13 necessary necessary JJ cord-015306-us58wwmp 3534 14 to to TO cord-015306-us58wwmp 3534 15 improve improve VB cord-015306-us58wwmp 3534 16 QOL QOL NNP cord-015306-us58wwmp 3534 17 in in IN cord-015306-us58wwmp 3534 18 children child NNS cord-015306-us58wwmp 3534 19 with with IN cord-015306-us58wwmp 3534 20 CKD CKD NNP cord-015306-us58wwmp 3534 21 . . . cord-015306-us58wwmp 3535 1 Abstract abstract JJ cord-015306-us58wwmp 3535 2 # # NN cord-015306-us58wwmp 3535 3 P p NN cord-015306-us58wwmp 3535 4 - - HYPH cord-015306-us58wwmp 3535 5 SAT398 sat398 NN cord-015306-us58wwmp 3535 6 Results result NNS cord-015306-us58wwmp 3535 7 : : : cord-015306-us58wwmp 3536 1 The the DT cord-015306-us58wwmp 3536 2 mean mean JJ cord-015306-us58wwmp 3536 3 period period NN cord-015306-us58wwmp 3536 4 of of IN cord-015306-us58wwmp 3536 5 post post JJ cord-015306-us58wwmp 3536 6 - - JJ cord-015306-us58wwmp 3536 7 transplant transplant JJ cord-015306-us58wwmp 3536 8 follow follow NN cord-015306-us58wwmp 3536 9 - - HYPH cord-015306-us58wwmp 3536 10 up up NN cord-015306-us58wwmp 3536 11 was be VBD cord-015306-us58wwmp 3536 12 4.7+/-2.1years(range 4.7+/-2.1years(range CD cord-015306-us58wwmp 3536 13 : : : cord-015306-us58wwmp 3536 14 0.8 0.8 CD cord-015306-us58wwmp 3536 15 - - SYM cord-015306-us58wwmp 3536 16 9 9 CD cord-015306-us58wwmp 3536 17 years year NNS cord-015306-us58wwmp 3536 18 ) ) -RRB- cord-015306-us58wwmp 3536 19 . . . cord-015306-us58wwmp 3537 1 In in IN cord-015306-us58wwmp 3537 2 the the DT cord-015306-us58wwmp 3537 3 first first JJ cord-015306-us58wwmp 3537 4 year year NN cord-015306-us58wwmp 3537 5 of of IN cord-015306-us58wwmp 3537 6 transplantation transplantation NN cord-015306-us58wwmp 3537 7 , , , cord-015306-us58wwmp 3537 8 14 14 CD cord-015306-us58wwmp 3537 9 ( ( -LRB- cord-015306-us58wwmp 3537 10 15.2 15.2 CD cord-015306-us58wwmp 3537 11 % % NN cord-015306-us58wwmp 3537 12 ) ) -RRB- cord-015306-us58wwmp 3537 13 recipients recipient NNS cord-015306-us58wwmp 3537 14 had have VBD cord-015306-us58wwmp 3537 15 obesity obesity NN cord-015306-us58wwmp 3538 1 Obese obese JJ cord-015306-us58wwmp 3538 2 patients patient NNS cord-015306-us58wwmp 3538 3 had have VBD cord-015306-us58wwmp 3538 4 higher high JJR cord-015306-us58wwmp 3538 5 serum serum NN cord-015306-us58wwmp 3538 6 GGT ggt NN cord-015306-us58wwmp 3538 7 levels level NNS cord-015306-us58wwmp 3538 8 than than IN cord-015306-us58wwmp 3538 9 non non JJ cord-015306-us58wwmp 3538 10 - - JJ cord-015306-us58wwmp 3538 11 obese obese JJ cord-015306-us58wwmp 3538 12 patients patient NNS cord-015306-us58wwmp 3539 1 ( ( -LRB- cord-015306-us58wwmp 3539 2 21.2+/-6.2 21.2+/-6.2 CD cord-015306-us58wwmp 3539 3 u u NNP cord-015306-us58wwmp 3539 4 / / SYM cord-015306-us58wwmp 3539 5 L L NNP cord-015306-us58wwmp 3539 6 vs vs IN cord-015306-us58wwmp 3539 7 14.9+/-3.8u 14.9+/-3.8u CD cord-015306-us58wwmp 3539 8 / / SYM cord-015306-us58wwmp 3539 9 L l NN cord-015306-us58wwmp 3539 10 , , , cord-015306-us58wwmp 3539 11 p=0.01 p=0.01 NNP cord-015306-us58wwmp 3539 12 ) ) -RRB- cord-015306-us58wwmp 3539 13 . . . cord-015306-us58wwmp 3540 1 There there EX cord-015306-us58wwmp 3540 2 was be VBD cord-015306-us58wwmp 3540 3 a a DT cord-015306-us58wwmp 3540 4 positive positive JJ cord-015306-us58wwmp 3540 5 correlation correlation NN cord-015306-us58wwmp 3540 6 between between IN cord-015306-us58wwmp 3540 7 BMI BMI NNP cord-015306-us58wwmp 3540 8 and and CC cord-015306-us58wwmp 3540 9 GGT GGT NNP cord-015306-us58wwmp 3540 10 and and CC cord-015306-us58wwmp 3540 11 TG TG NNP cord-015306-us58wwmp 3540 12 levels level NNS cord-015306-us58wwmp 3540 13 in in IN cord-015306-us58wwmp 3540 14 obese obese JJ cord-015306-us58wwmp 3540 15 patients patient NNS cord-015306-us58wwmp 3540 16 ( ( -LRB- cord-015306-us58wwmp 3540 17 r=0.61 r=0.61 JJ cord-015306-us58wwmp 3540 18 , , , cord-015306-us58wwmp 3540 19 and and CC cord-015306-us58wwmp 3540 20 r=0.5 r=0.5 NNP cord-015306-us58wwmp 3540 21 , , , cord-015306-us58wwmp 3540 22 p<0.01 p<0.01 NNP cord-015306-us58wwmp 3540 23 respectively respectively RB cord-015306-us58wwmp 3540 24 ) ) -RRB- cord-015306-us58wwmp 3540 25 . . . cord-015306-us58wwmp 3541 1 Patients patient NNS cord-015306-us58wwmp 3541 2 with with IN cord-015306-us58wwmp 3541 3 dyslipidemia dyslipidemia NN cord-015306-us58wwmp 3541 4 were be VBD cord-015306-us58wwmp 3541 5 found find VBN cord-015306-us58wwmp 3541 6 to to TO cord-015306-us58wwmp 3541 7 have have VB cord-015306-us58wwmp 3541 8 significantly significantly RB cord-015306-us58wwmp 3541 9 higher high JJR cord-015306-us58wwmp 3541 10 mean mean JJ cord-015306-us58wwmp 3541 11 GGT GGT NNP cord-015306-us58wwmp 3541 12 level level NN cord-015306-us58wwmp 3541 13 ( ( -LRB- cord-015306-us58wwmp 3541 14 14.2+/-3.6 14.2+/-3.6 CD cord-015306-us58wwmp 3541 15 u u NNP cord-015306-us58wwmp 3541 16 / / SYM cord-015306-us58wwmp 3541 17 L l NN cord-015306-us58wwmp 3541 18 vs. vs. FW cord-015306-us58wwmp 3541 19 19.2+/-6.2 19.2+/-6.2 CD cord-015306-us58wwmp 3541 20 u u NNP cord-015306-us58wwmp 3541 21 / / SYM cord-015306-us58wwmp 3541 22 L L NNP cord-015306-us58wwmp 3541 23 , , , cord-015306-us58wwmp 3541 24 p=0.016 p=0.016 JJS cord-015306-us58wwmp 3541 25 ) ) -RRB- cord-015306-us58wwmp 3541 26 and and CC cord-015306-us58wwmp 3541 27 BMI BMI NNP cord-015306-us58wwmp 3541 28 ( ( -LRB- cord-015306-us58wwmp 3541 29 18.6+/-3.4 18.6+/-3.4 CD cord-015306-us58wwmp 3541 30 vs. vs. IN cord-015306-us58wwmp 3541 31 29.4+/-6.3 29.4+/-6.3 CD cord-015306-us58wwmp 3541 32 p=0.04 p=0.04 NNP cord-015306-us58wwmp 3541 33 ) ) -RRB- cord-015306-us58wwmp 3541 34 . . . cord-015306-us58wwmp 3542 1 We -PRON- PRP cord-015306-us58wwmp 3542 2 could could MD cord-015306-us58wwmp 3542 3 not not RB cord-015306-us58wwmp 3542 4 find find VB cord-015306-us58wwmp 3542 5 any any DT cord-015306-us58wwmp 3542 6 correlation correlation NN cord-015306-us58wwmp 3542 7 between between IN cord-015306-us58wwmp 3542 8 BMI BMI NNP cord-015306-us58wwmp 3542 9 , , , cord-015306-us58wwmp 3542 10 and and CC cord-015306-us58wwmp 3542 11 gender gender NN cord-015306-us58wwmp 3542 12 , , , cord-015306-us58wwmp 3542 13 post post NN cord-015306-us58wwmp 3542 14 - - JJ cord-015306-us58wwmp 3542 15 transplant transplant JJ cord-015306-us58wwmp 3542 16 follow follow NN cord-015306-us58wwmp 3542 17 - - HYPH cord-015306-us58wwmp 3542 18 up up NN cord-015306-us58wwmp 3542 19 , , , cord-015306-us58wwmp 3542 20 duration duration NN cord-015306-us58wwmp 3542 21 of of IN cord-015306-us58wwmp 3542 22 CRF CRF NNP cord-015306-us58wwmp 3542 23 , , , cord-015306-us58wwmp 3542 24 primary primary JJ cord-015306-us58wwmp 3542 25 disease disease NN cord-015306-us58wwmp 3542 26 , , , cord-015306-us58wwmp 3542 27 donor donor NN cord-015306-us58wwmp 3542 28 status status NN cord-015306-us58wwmp 3542 29 and and CC cord-015306-us58wwmp 3542 30 graft graft NN cord-015306-us58wwmp 3542 31 loss loss NN cord-015306-us58wwmp 3542 32 . . . cord-015306-us58wwmp 3543 1 In in IN cord-015306-us58wwmp 3543 2 the the DT cord-015306-us58wwmp 3543 3 first first JJ cord-015306-us58wwmp 3543 4 year year NN cord-015306-us58wwmp 3543 5 of of IN cord-015306-us58wwmp 3543 6 transplantation transplantation NN cord-015306-us58wwmp 3543 7 , , , cord-015306-us58wwmp 3543 8 GFR GFR NNP cord-015306-us58wwmp 3543 9 was be VBD cord-015306-us58wwmp 3543 10 significantly significantly RB cord-015306-us58wwmp 3543 11 lower low JJR cord-015306-us58wwmp 3543 12 in in IN cord-015306-us58wwmp 3543 13 obese obese JJ cord-015306-us58wwmp 3543 14 patients patient NNS cord-015306-us58wwmp 3543 15 than than IN cord-015306-us58wwmp 3543 16 non non JJ cord-015306-us58wwmp 3543 17 - - JJ cord-015306-us58wwmp 3543 18 obese obese JJ cord-015306-us58wwmp 3543 19 recipients recipient NNS cord-015306-us58wwmp 3543 20 ( ( -LRB- cord-015306-us58wwmp 3543 21 p<0.05 p<0.05 CD cord-015306-us58wwmp 3543 22 ) ) -RRB- cord-015306-us58wwmp 3544 1 Conclusion conclusion NN cord-015306-us58wwmp 3544 2 : : : cord-015306-us58wwmp 3545 1 Our -PRON- PRP$ cord-015306-us58wwmp 3545 2 data datum NNS cord-015306-us58wwmp 3545 3 has have VBZ cord-015306-us58wwmp 3545 4 suggested suggest VBN cord-015306-us58wwmp 3545 5 that that IN cord-015306-us58wwmp 3545 6 , , , cord-015306-us58wwmp 3545 7 even even RB cord-015306-us58wwmp 3545 8 within within IN cord-015306-us58wwmp 3545 9 its -PRON- PRP$ cord-015306-us58wwmp 3545 10 normal normal JJ cord-015306-us58wwmp 3545 11 range range NN cord-015306-us58wwmp 3545 12 , , , cord-015306-us58wwmp 3545 13 elevated elevated JJ cord-015306-us58wwmp 3545 14 serum serum NN cord-015306-us58wwmp 3545 15 GGT ggt NN cord-015306-us58wwmp 3545 16 concentrations concentration NNS cord-015306-us58wwmp 3545 17 and and CC cord-015306-us58wwmp 3545 18 hyperlipidemia hyperlipidemia NN cord-015306-us58wwmp 3545 19 are be VBP cord-015306-us58wwmp 3545 20 closely closely RB cord-015306-us58wwmp 3545 21 associated associate VBN cord-015306-us58wwmp 3545 22 with with IN cord-015306-us58wwmp 3545 23 obesity obesity NN cord-015306-us58wwmp 3545 24 in in IN cord-015306-us58wwmp 3545 25 transplanted transplanted JJ cord-015306-us58wwmp 3545 26 patients patient NNS cord-015306-us58wwmp 3545 27 and and CC cord-015306-us58wwmp 3545 28 obesity obesity NN cord-015306-us58wwmp 3545 29 has have VBZ cord-015306-us58wwmp 3545 30 negative negative JJ cord-015306-us58wwmp 3545 31 effects effect NNS cord-015306-us58wwmp 3545 32 on on IN cord-015306-us58wwmp 3545 33 graft graft NN cord-015306-us58wwmp 3545 34 functions function NNS cord-015306-us58wwmp 3545 35 . . . cord-015306-us58wwmp 3546 1 The the DT cord-015306-us58wwmp 3546 2 relationship relationship NN cord-015306-us58wwmp 3546 3 between between IN cord-015306-us58wwmp 3546 4 the the DT cord-015306-us58wwmp 3546 5 graft graft NN cord-015306-us58wwmp 3546 6 function function NN cord-015306-us58wwmp 3546 7 and and CC cord-015306-us58wwmp 3546 8 the the DT cord-015306-us58wwmp 3546 9 serum serum NN cord-015306-us58wwmp 3546 10 and and CC cord-015306-us58wwmp 3546 11 urine urine NN cord-015306-us58wwmp 3546 12 NGAL NGAL NNP cord-015306-us58wwmp 3546 13 in in IN cord-015306-us58wwmp 3546 14 children child NNS cord-015306-us58wwmp 3546 15 with with IN cord-015306-us58wwmp 3546 16 renal renal JJ cord-015306-us58wwmp 3546 17 transplantation transplantation NN cord-015306-us58wwmp 3546 18 Tehran Tehran NNP cord-015306-us58wwmp 3546 19 university university NN cord-015306-us58wwmp 3546 20 of of IN cord-015306-us58wwmp 3546 21 medical medical JJ cord-015306-us58wwmp 3546 22 science science NN cord-015306-us58wwmp 3546 23 , , , cord-015306-us58wwmp 3546 24 associated associated JJ cord-015306-us58wwmp 3546 25 professor professor NN cord-015306-us58wwmp 3546 26 , , , cord-015306-us58wwmp 3546 27 Tehran Tehran NNP cord-015306-us58wwmp 3546 28 , , , cord-015306-us58wwmp 3547 1 Iran Iran NNP cord-015306-us58wwmp 3547 2 Objective Objective NNP cord-015306-us58wwmp 3547 3 : : : cord-015306-us58wwmp 3548 1 The the DT cord-015306-us58wwmp 3548 2 evaluation evaluation NN cord-015306-us58wwmp 3548 3 of of IN cord-015306-us58wwmp 3548 4 graft graft NN cord-015306-us58wwmp 3548 5 function function NN cord-015306-us58wwmp 3548 6 long long JJ cord-015306-us58wwmp 3548 7 term term NN cord-015306-us58wwmp 3548 8 after after IN cord-015306-us58wwmp 3548 9 transplantation transplantation NN cord-015306-us58wwmp 3548 10 is be VBZ cord-015306-us58wwmp 3548 11 important important JJ cord-015306-us58wwmp 3548 12 . . . cord-015306-us58wwmp 3549 1 Serum serum NN cord-015306-us58wwmp 3549 2 creatinine creatinine NN cord-015306-us58wwmp 3549 3 is be VBZ cord-015306-us58wwmp 3549 4 the the DT cord-015306-us58wwmp 3549 5 most most RBS cord-015306-us58wwmp 3549 6 common common JJ cord-015306-us58wwmp 3549 7 used use VBN cord-015306-us58wwmp 3549 8 marker marker NN cord-015306-us58wwmp 3549 9 for for IN cord-015306-us58wwmp 3549 10 graft graft NN cord-015306-us58wwmp 3549 11 function function NN cord-015306-us58wwmp 3549 12 in in IN cord-015306-us58wwmp 3549 13 renal renal JJ cord-015306-us58wwmp 3549 14 transplantation transplantation NN cord-015306-us58wwmp 3549 15 . . . cord-015306-us58wwmp 3550 1 The the DT cord-015306-us58wwmp 3550 2 level level NN cord-015306-us58wwmp 3550 3 of of IN cord-015306-us58wwmp 3550 4 serum serum NN cord-015306-us58wwmp 3550 5 and and CC cord-015306-us58wwmp 3550 6 urine urine NN cord-015306-us58wwmp 3550 7 NGAL NGAL NNP cord-015306-us58wwmp 3550 8 may may MD cord-015306-us58wwmp 3550 9 predict predict VB cord-015306-us58wwmp 3550 10 graft graft NN cord-015306-us58wwmp 3550 11 function function NN cord-015306-us58wwmp 3550 12 in in IN cord-015306-us58wwmp 3550 13 renal renal JJ cord-015306-us58wwmp 3550 14 transplant transplant NN cord-015306-us58wwmp 3550 15 recipients recipient NNS cord-015306-us58wwmp 3550 16 . . . cord-015306-us58wwmp 3551 1 Methods method NNS cord-015306-us58wwmp 3551 2 : : : cord-015306-us58wwmp 3551 3 We -PRON- PRP cord-015306-us58wwmp 3551 4 evaluated evaluate VBD cord-015306-us58wwmp 3551 5 21 21 CD cord-015306-us58wwmp 3551 6 pediatric pediatric JJ cord-015306-us58wwmp 3551 7 renal renal JJ cord-015306-us58wwmp 3551 8 transplant transplant NN cord-015306-us58wwmp 3551 9 recipients recipient NNS cord-015306-us58wwmp 3551 10 by by IN cord-015306-us58wwmp 3551 11 measurement measurement NN cord-015306-us58wwmp 3551 12 of of IN cord-015306-us58wwmp 3551 13 serum serum NN cord-015306-us58wwmp 3551 14 and and CC cord-015306-us58wwmp 3551 15 urine urine NN cord-015306-us58wwmp 3551 16 NGAL NGAL NNP cord-015306-us58wwmp 3551 17 , , , cord-015306-us58wwmp 3551 18 serum serum NN cord-015306-us58wwmp 3551 19 creatinine creatinine NN cord-015306-us58wwmp 3551 20 concurrently concurrently RB cord-015306-us58wwmp 3551 21 . . . cord-015306-us58wwmp 3552 1 The the DT cord-015306-us58wwmp 3552 2 GFR GFR NNP cord-015306-us58wwmp 3552 3 of of IN cord-015306-us58wwmp 3552 4 the the DT cord-015306-us58wwmp 3552 5 patients patient NNS cord-015306-us58wwmp 3552 6 was be VBD cord-015306-us58wwmp 3552 7 also also RB cord-015306-us58wwmp 3552 8 estimated estimate VBN cord-015306-us58wwmp 3552 9 by by IN cord-015306-us58wwmp 3552 10 Schwartz Schwartz NNP cord-015306-us58wwmp 3552 11 formula formula NN cord-015306-us58wwmp 3552 12 . . . cord-015306-us58wwmp 3553 1 Results result NNS cord-015306-us58wwmp 3553 2 and and CC cord-015306-us58wwmp 3553 3 Conclusion conclusion NN cord-015306-us58wwmp 3553 4 : : : cord-015306-us58wwmp 3554 1 The the DT cord-015306-us58wwmp 3554 2 time time NN cord-015306-us58wwmp 3554 3 after after IN cord-015306-us58wwmp 3554 4 transplantation transplantation NN cord-015306-us58wwmp 3554 5 was be VBD cord-015306-us58wwmp 3554 6 3 3 CD cord-015306-us58wwmp 3554 7 - - SYM cord-015306-us58wwmp 3554 8 12 12 CD cord-015306-us58wwmp 3554 9 years year NNS cord-015306-us58wwmp 3555 1 ( ( -LRB- cord-015306-us58wwmp 3555 2 mean mean VB cord-015306-us58wwmp 3555 3 : : : cord-015306-us58wwmp 3555 4 6.8+/-2.47 6.8+/-2.47 CD cord-015306-us58wwmp 3555 5 years year NNS cord-015306-us58wwmp 3555 6 ) ) -RRB- cord-015306-us58wwmp 3555 7 . . . cord-015306-us58wwmp 3556 1 The the DT cord-015306-us58wwmp 3556 2 mean mean JJ cord-015306-us58wwmp 3556 3 serum serum NN cord-015306-us58wwmp 3556 4 NGAL NGAL NNP cord-015306-us58wwmp 3556 5 was be VBD cord-015306-us58wwmp 3556 6 140+/-94.2 140+/-94.2 CD cord-015306-us58wwmp 3556 7 ng ng NNP cord-015306-us58wwmp 3556 8 / / SYM cord-015306-us58wwmp 3556 9 ml ml NN cord-015306-us58wwmp 3556 10 ( ( -LRB- cord-015306-us58wwmp 3556 11 15.4 15.4 CD cord-015306-us58wwmp 3556 12 - - SYM cord-015306-us58wwmp 3556 13 324 324 CD cord-015306-us58wwmp 3556 14 ) ) -RRB- cord-015306-us58wwmp 3556 15 . . . cord-015306-us58wwmp 3557 1 The the DT cord-015306-us58wwmp 3557 2 mean mean JJ cord-015306-us58wwmp 3557 3 urine urine NN cord-015306-us58wwmp 3557 4 NGAL NGAL NNP cord-015306-us58wwmp 3557 5 was be VBD cord-015306-us58wwmp 3557 6 17.8+/-20 17.8+/-20 CD cord-015306-us58wwmp 3557 7 ng ng NNP cord-015306-us58wwmp 3557 8 / / SYM cord-015306-us58wwmp 3557 9 ml ml NN cord-015306-us58wwmp 3557 10 ( ( -LRB- cord-015306-us58wwmp 3557 11 32 32 CD cord-015306-us58wwmp 3557 12 - - SYM cord-015306-us58wwmp 3557 13 68 68 CD cord-015306-us58wwmp 3557 14 ) ) -RRB- cord-015306-us58wwmp 3557 15 . . . cord-015306-us58wwmp 3558 1 We -PRON- PRP cord-015306-us58wwmp 3558 2 did do VBD cord-015306-us58wwmp 3558 3 n't not RB cord-015306-us58wwmp 3558 4 find find VB cord-015306-us58wwmp 3558 5 any any DT cord-015306-us58wwmp 3558 6 association association NN cord-015306-us58wwmp 3558 7 between between IN cord-015306-us58wwmp 3558 8 serum serum NN cord-015306-us58wwmp 3558 9 creatinine creatinine NN cord-015306-us58wwmp 3558 10 , , , cord-015306-us58wwmp 3558 11 GFR GFR NNP cord-015306-us58wwmp 3558 12 estimated estimate VBN cord-015306-us58wwmp 3558 13 by by IN cord-015306-us58wwmp 3558 14 Schwarz Schwarz NNP cord-015306-us58wwmp 3558 15 and and CC cord-015306-us58wwmp 3558 16 serum serum NN cord-015306-us58wwmp 3558 17 NGAL NGAL NNP cord-015306-us58wwmp 3558 18 . . . cord-015306-us58wwmp 3559 1 We -PRON- PRP cord-015306-us58wwmp 3559 2 also also RB cord-015306-us58wwmp 3559 3 didn'y didn'y VBZ cord-015306-us58wwmp 3559 4 find find VBP cord-015306-us58wwmp 3559 5 any any DT cord-015306-us58wwmp 3559 6 association association NN cord-015306-us58wwmp 3559 7 between between IN cord-015306-us58wwmp 3559 8 urine urine NN cord-015306-us58wwmp 3559 9 creatinine creatinine NN cord-015306-us58wwmp 3559 10 , , , cord-015306-us58wwmp 3559 11 GFR GFR NNP cord-015306-us58wwmp 3559 12 estimated estimate VBN cord-015306-us58wwmp 3559 13 by by IN cord-015306-us58wwmp 3559 14 Schwarz Schwarz NNP cord-015306-us58wwmp 3559 15 and and CC cord-015306-us58wwmp 3559 16 serum serum NN cord-015306-us58wwmp 3559 17 NGAL NGAL NNP cord-015306-us58wwmp 3559 18 . . . cord-015306-us58wwmp 3560 1 Glomerular glomerular JJ cord-015306-us58wwmp 3560 2 filtration filtration NN cord-015306-us58wwmp 3560 3 rate rate NN cord-015306-us58wwmp 3560 4 measured measure VBN cord-015306-us58wwmp 3560 5 by by IN cord-015306-us58wwmp 3560 6 DTPA DTPA NNP cord-015306-us58wwmp 3560 7 scan scan NN cord-015306-us58wwmp 3560 8 of of IN cord-015306-us58wwmp 3560 9 fourteen fourteen CD cord-015306-us58wwmp 3560 10 patients patient NNS cord-015306-us58wwmp 3560 11 were be VBD cord-015306-us58wwmp 3560 12 available available JJ cord-015306-us58wwmp 3560 13 . . . cord-015306-us58wwmp 3561 1 We -PRON- PRP cord-015306-us58wwmp 3561 2 also also RB cord-015306-us58wwmp 3561 3 did do VBD cord-015306-us58wwmp 3561 4 n't not RB cord-015306-us58wwmp 3561 5 any any DT cord-015306-us58wwmp 3561 6 association association NN cord-015306-us58wwmp 3561 7 between between IN cord-015306-us58wwmp 3561 8 GFR GFR NNP cord-015306-us58wwmp 3561 9 measured measure VBN cord-015306-us58wwmp 3561 10 by by IN cord-015306-us58wwmp 3561 11 DTPA DTPA NNP cord-015306-us58wwmp 3561 12 scan scan NN cord-015306-us58wwmp 3561 13 and and CC cord-015306-us58wwmp 3561 14 serum serum NN cord-015306-us58wwmp 3561 15 and and CC cord-015306-us58wwmp 3561 16 urine urine NN cord-015306-us58wwmp 3561 17 NGAL NGAL NNP cord-015306-us58wwmp 3561 18 . . . cord-015306-us58wwmp 3562 1 Abstract abstract JJ cord-015306-us58wwmp 3562 2 # # NN cord-015306-us58wwmp 3563 1 P p NN cord-015306-us58wwmp 3563 2 - - NN cord-015306-us58wwmp 3563 3 SAT409 sat409 JJ cord-015306-us58wwmp 3564 1 Racial racial JJ cord-015306-us58wwmp 3564 2 disparities disparity NNS cord-015306-us58wwmp 3564 3 in in IN cord-015306-us58wwmp 3564 4 paediatric paediatric JJ cord-015306-us58wwmp 3564 5 kidney kidney NN cord-015306-us58wwmp 3564 6 transplantation transplantation NN cord-015306-us58wwmp 3564 7 in in IN cord-015306-us58wwmp 3564 8 Australia Australia NNP cord-015306-us58wwmp 3564 9 Glomerulonephritis Glomerulonephritis NNP cord-015306-us58wwmp 3564 10 and and CC cord-015306-us58wwmp 3564 11 late late JJ cord-015306-us58wwmp 3564 12 referral referral NN cord-015306-us58wwmp 3564 13 were be VBD cord-015306-us58wwmp 3564 14 more more RBR cord-015306-us58wwmp 3564 15 common common JJ cord-015306-us58wwmp 3564 16 in in IN cord-015306-us58wwmp 3564 17 non non JJ cord-015306-us58wwmp 3564 18 - - JJ cord-015306-us58wwmp 3564 19 Caucasian caucasian JJ cord-015306-us58wwmp 3564 20 patients patient NNS cord-015306-us58wwmp 3564 21 . . . cord-015306-us58wwmp 3565 1 Among among IN cord-015306-us58wwmp 3565 2 patients patient NNS cord-015306-us58wwmp 3565 3 who who WP cord-015306-us58wwmp 3565 4 did do VBD cord-015306-us58wwmp 3565 5 receive receive VB cord-015306-us58wwmp 3565 6 a a DT cord-015306-us58wwmp 3565 7 transplant transplant NN cord-015306-us58wwmp 3565 8 , , , cord-015306-us58wwmp 3565 9 Caucasians Caucasians NNPS cord-015306-us58wwmp 3565 10 had have VBD cord-015306-us58wwmp 3565 11 overall overall RB cord-015306-us58wwmp 3565 12 better well JJR cord-015306-us58wwmp 3565 13 HLA HLA NNP cord-015306-us58wwmp 3565 14 matches match NNS cord-015306-us58wwmp 3565 15 to to IN cord-015306-us58wwmp 3565 16 their -PRON- PRP$ cord-015306-us58wwmp 3565 17 graft graft NN cord-015306-us58wwmp 3565 18 and and CC cord-015306-us58wwmp 3565 19 were be VBD cord-015306-us58wwmp 3565 20 less less RBR cord-015306-us58wwmp 3565 21 sensitised sensitised JJ cord-015306-us58wwmp 3565 22 . . . cord-015306-us58wwmp 3566 1 Conclusion conclusion NN cord-015306-us58wwmp 3566 2 : : : cord-015306-us58wwmp 3567 1 Caucasian caucasian JJ cord-015306-us58wwmp 3567 2 Australian australian JJ cord-015306-us58wwmp 3567 3 paediatric paediatric JJ cord-015306-us58wwmp 3567 4 patients patient NNS cord-015306-us58wwmp 3567 5 have have VBP cord-015306-us58wwmp 3567 6 greater great JJR cord-015306-us58wwmp 3567 7 access access NN cord-015306-us58wwmp 3567 8 to to IN cord-015306-us58wwmp 3567 9 kidney kidney NN cord-015306-us58wwmp 3567 10 transplantation transplantation NN cord-015306-us58wwmp 3567 11 , , , cord-015306-us58wwmp 3567 12 particularly particularly RB cord-015306-us58wwmp 3567 13 from from IN cord-015306-us58wwmp 3567 14 living live VBG cord-015306-us58wwmp 3567 15 donors donor NNS cord-015306-us58wwmp 3567 16 , , , cord-015306-us58wwmp 3567 17 and and CC cord-015306-us58wwmp 3567 18 are be VBP cord-015306-us58wwmp 3567 19 likely likely JJ cord-015306-us58wwmp 3567 20 to to TO cord-015306-us58wwmp 3567 21 have have VB cord-015306-us58wwmp 3567 22 the the DT cord-015306-us58wwmp 3567 23 better well JJR cord-015306-us58wwmp 3567 24 graft graft NN cord-015306-us58wwmp 3567 25 survival survival NN cord-015306-us58wwmp 3567 26 . . . cord-015306-us58wwmp 3568 1 Some some DT cord-015306-us58wwmp 3568 2 racial racial JJ cord-015306-us58wwmp 3568 3 disparities disparity NNS cord-015306-us58wwmp 3568 4 may may MD cord-015306-us58wwmp 3568 5 be be VB cord-015306-us58wwmp 3568 6 inevitable inevitable JJ cord-015306-us58wwmp 3568 7 due due IN cord-015306-us58wwmp 3568 8 to to IN cord-015306-us58wwmp 3568 9 differences difference NNS cord-015306-us58wwmp 3568 10 in in IN cord-015306-us58wwmp 3568 11 kidney kidney NN cord-015306-us58wwmp 3568 12 diseases disease NNS cord-015306-us58wwmp 3568 13 , , , cord-015306-us58wwmp 3568 14 however however RB cord-015306-us58wwmp 3568 15 further further JJ cord-015306-us58wwmp 3568 16 work work NN cord-015306-us58wwmp 3568 17 is be VBZ cord-015306-us58wwmp 3568 18 required require VBN cord-015306-us58wwmp 3568 19 to to TO cord-015306-us58wwmp 3568 20 understand understand VB cord-015306-us58wwmp 3568 21 barriers barrier NNS cord-015306-us58wwmp 3568 22 to to TO cord-015306-us58wwmp 3568 23 live live VB cord-015306-us58wwmp 3568 24 donation donation NN cord-015306-us58wwmp 3568 25 and and CC cord-015306-us58wwmp 3568 26 address address NN cord-015306-us58wwmp 3568 27 disparities disparity NNS cord-015306-us58wwmp 3568 28 . . . cord-015306-us58wwmp 3569 1 Abstract abstract JJ cord-015306-us58wwmp 3569 2 # # NN cord-015306-us58wwmp 3569 3 P p NN cord-015306-us58wwmp 3569 4 - - HYPH cord-015306-us58wwmp 3569 5 SAT410 SAT410 NNP cord-015306-us58wwmp 3569 6 Cost cost NN cord-015306-us58wwmp 3569 7 - - HYPH cord-015306-us58wwmp 3569 8 effectiveness effectiveness NN cord-015306-us58wwmp 3569 9 of of IN cord-015306-us58wwmp 3569 10 renal renal JJ cord-015306-us58wwmp 3569 11 transplantation transplantation NN cord-015306-us58wwmp 3569 12 in in IN cord-015306-us58wwmp 3569 13 paediatric paediatric JJ cord-015306-us58wwmp 3569 14 and and CC cord-015306-us58wwmp 3569 15 adult adult NN cord-015306-us58wwmp 3569 16 transplant transplant NN cord-015306-us58wwmp 3569 17 recipients recipient NNS cord-015306-us58wwmp 3569 18 . . . cord-015306-us58wwmp 3570 1 [ [ -LRB- cord-015306-us58wwmp 3570 2 1.4 1.4 CD cord-015306-us58wwmp 3570 3 - - SYM cord-015306-us58wwmp 3570 4 4.8 4.8 CD cord-015306-us58wwmp 3570 5 ] ] -RRB- cord-015306-us58wwmp 3570 6 ) ) -RRB- cord-015306-us58wwmp 3570 7 , , , cord-015306-us58wwmp 3570 8 were be VBD cord-015306-us58wwmp 3570 9 associated associate VBN cord-015306-us58wwmp 3570 10 with with IN cord-015306-us58wwmp 3570 11 a a DT cord-015306-us58wwmp 3570 12 lower low JJR cord-015306-us58wwmp 3570 13 inscription inscription NN cord-015306-us58wwmp 3570 14 probability probability NN cord-015306-us58wwmp 3570 15 6 6 CD cord-015306-us58wwmp 3570 16 months month NNS cord-015306-us58wwmp 3570 17 after after IN cord-015306-us58wwmp 3570 18 reaching reach VBG cord-015306-us58wwmp 3570 19 ESRD ESRD NNP cord-015306-us58wwmp 3570 20 . . . cord-015306-us58wwmp 3571 1 The the DT cord-015306-us58wwmp 3571 2 national national JJ cord-015306-us58wwmp 3571 3 inscription inscription NN cord-015306-us58wwmp 3571 4 rate rate NN cord-015306-us58wwmp 3571 5 was be VBD cord-015306-us58wwmp 3571 6 69 69 CD cord-015306-us58wwmp 3571 7 % % NN cord-015306-us58wwmp 3571 8 with with IN cord-015306-us58wwmp 3571 9 a a DT cord-015306-us58wwmp 3571 10 significant significant JJ cord-015306-us58wwmp 3571 11 center center NN cord-015306-us58wwmp 3571 12 variability variability NN cord-015306-us58wwmp 3571 13 ( ( -LRB- cord-015306-us58wwmp 3571 14 median median NN cord-015306-us58wwmp 3571 15 69 69 CD cord-015306-us58wwmp 3571 16 % % NN cord-015306-us58wwmp 3571 17 [ [ -LRB- cord-015306-us58wwmp 3571 18 IQR IQR NNP cord-015306-us58wwmp 3571 19 51 51 CD cord-015306-us58wwmp 3571 20 - - SYM cord-015306-us58wwmp 3571 21 80 80 CD cord-015306-us58wwmp 3571 22 ] ] -RRB- cord-015306-us58wwmp 3571 23 ) ) -RRB- cord-015306-us58wwmp 3571 24 that that WDT cord-015306-us58wwmp 3571 25 remained remain VBD cord-015306-us58wwmp 3571 26 after after IN cord-015306-us58wwmp 3571 27 adjustment adjustment NN cord-015306-us58wwmp 3571 28 on on IN cord-015306-us58wwmp 3571 29 patient patient JJ cord-015306-us58wwmp 3571 30 characteristics characteristic NNS cord-015306-us58wwmp 3571 31 ( ( -LRB- cord-015306-us58wwmp 3571 32 p<0.0001 p<0.0001 NNP cord-015306-us58wwmp 3571 33 ) ) -RRB- cord-015306-us58wwmp 3571 34 . . . cord-015306-us58wwmp 3572 1 Preemptive preemptive JJ cord-015306-us58wwmp 3572 2 transplantation transplantation NN cord-015306-us58wwmp 3572 3 rate rate NN cord-015306-us58wwmp 3572 4 explained explain VBD cord-015306-us58wwmp 3572 5 19 19 CD cord-015306-us58wwmp 3572 6 % % NN cord-015306-us58wwmp 3572 7 of of IN cord-015306-us58wwmp 3572 8 the the DT cord-015306-us58wwmp 3572 9 inter inter JJ cord-015306-us58wwmp 3572 10 - - JJ cord-015306-us58wwmp 3572 11 center center JJ cord-015306-us58wwmp 3572 12 variability variability NN cord-015306-us58wwmp 3572 13 ( ( -LRB- cord-015306-us58wwmp 3572 14 p=0.06 p=0.06 NNP cord-015306-us58wwmp 3572 15 ) ) -RRB- cord-015306-us58wwmp 3572 16 . . . cord-015306-us58wwmp 3573 1 Probability probability NN cord-015306-us58wwmp 3573 2 of of IN cord-015306-us58wwmp 3573 3 transplantation transplantation NN cord-015306-us58wwmp 3573 4 12 12 CD cord-015306-us58wwmp 3573 5 months month NNS cord-015306-us58wwmp 3573 6 after after IN cord-015306-us58wwmp 3573 7 inscription inscription NN cord-015306-us58wwmp 3573 8 decreased decrease VBD cord-015306-us58wwmp 3573 9 with with IN cord-015306-us58wwmp 3573 10 time time NN cord-015306-us58wwmp 3573 11 of of IN cord-015306-us58wwmp 3573 12 waiting wait VBG cord-015306-us58wwmp 3573 13 list list NN cord-015306-us58wwmp 3573 14 inactivity inactivity NN cord-015306-us58wwmp 3573 15 ( ( -LRB- cord-015306-us58wwmp 3573 16 p<0.0001 p<0.0001 NNP cord-015306-us58wwmp 3573 17 ) ) -RRB- cord-015306-us58wwmp 3573 18 and and CC cord-015306-us58wwmp 3573 19 with with IN cord-015306-us58wwmp 3573 20 the the DT cord-015306-us58wwmp 3573 21 probability probability NN cord-015306-us58wwmp 3573 22 of of IN cord-015306-us58wwmp 3573 23 finding find VBG cord-015306-us58wwmp 3573 24 a a DT cord-015306-us58wwmp 3573 25 compatible compatible JJ cord-015306-us58wwmp 3573 26 transplant transplant NN cord-015306-us58wwmp 3573 27 considering consider VBG cord-015306-us58wwmp 3573 28 patient patient NN cord-015306-us58wwmp 3573 29 's 's POS cord-015306-us58wwmp 3573 30 HLA HLA NNP cord-015306-us58wwmp 3573 31 and and CC cord-015306-us58wwmp 3573 32 ABO ABO NNP cord-015306-us58wwmp 3573 33 groups group NNS cord-015306-us58wwmp 3573 34 . . . cord-015306-us58wwmp 3574 1 Underweight underweight JJ cord-015306-us58wwmp 3574 2 ( ( -LRB- cord-015306-us58wwmp 3574 3 BMI BMI NNP cord-015306-us58wwmp 3574 4 < < XX cord-015306-us58wwmp 3574 5 -2SD -2SD , cord-015306-us58wwmp 3574 6 ) ) -RRB- cord-015306-us58wwmp 3574 7 was be VBD cord-015306-us58wwmp 3574 8 associated associate VBN cord-015306-us58wwmp 3574 9 with with IN cord-015306-us58wwmp 3574 10 lower low JJR cord-015306-us58wwmp 3574 11 transplant transplant NN cord-015306-us58wwmp 3574 12 probability probability NN cord-015306-us58wwmp 3574 13 ( ( -LRB- cord-015306-us58wwmp 3574 14 OR or CC cord-015306-us58wwmp 3574 15 0.3 0.3 CD cord-015306-us58wwmp 3574 16 [ [ -LRB- cord-015306-us58wwmp 3574 17 0.1 0.1 CD cord-015306-us58wwmp 3574 18 - - SYM cord-015306-us58wwmp 3574 19 0.9 0.9 CD cord-015306-us58wwmp 3574 20 ] ] -RRB- cord-015306-us58wwmp 3574 21 ) ) -RRB- cord-015306-us58wwmp 3574 22 . . . cord-015306-us58wwmp 3575 1 At at IN cord-015306-us58wwmp 3575 2 12 12 CD cord-015306-us58wwmp 3575 3 months month NNS cord-015306-us58wwmp 3575 4 , , , cord-015306-us58wwmp 3575 5 81 81 CD cord-015306-us58wwmp 3575 6 % % NN cord-015306-us58wwmp 3575 7 of of IN cord-015306-us58wwmp 3575 8 patients patient NNS cord-015306-us58wwmp 3575 9 were be VBD cord-015306-us58wwmp 3575 10 transplanted transplant VBN cord-015306-us58wwmp 3575 11 with with IN cord-015306-us58wwmp 3575 12 a a DT cord-015306-us58wwmp 3575 13 significant significant JJ cord-015306-us58wwmp 3575 14 center center NN cord-015306-us58wwmp 3575 15 variability variability NN cord-015306-us58wwmp 3575 16 ( ( -LRB- cord-015306-us58wwmp 3575 17 median median NN cord-015306-us58wwmp 3575 18 80 80 CD cord-015306-us58wwmp 3575 19 % % NN cord-015306-us58wwmp 3575 20 [ [ -LRB- cord-015306-us58wwmp 3575 21 IQR IQR NNP cord-015306-us58wwmp 3575 22 72 72 CD cord-015306-us58wwmp 3575 23 - - SYM cord-015306-us58wwmp 3575 24 88 88 CD cord-015306-us58wwmp 3575 25 ] ] -RRB- cord-015306-us58wwmp 3575 26 that that WDT cord-015306-us58wwmp 3575 27 remained remain VBD cord-015306-us58wwmp 3575 28 after after IN cord-015306-us58wwmp 3575 29 adjustment adjustment NN cord-015306-us58wwmp 3575 30 ( ( -LRB- cord-015306-us58wwmp 3575 31 p=0.02 p=0.02 NN cord-015306-us58wwmp 3575 32 ) ) -RRB- cord-015306-us58wwmp 3575 33 . . . cord-015306-us58wwmp 3576 1 Conclusion conclusion NN cord-015306-us58wwmp 3576 2 : : : cord-015306-us58wwmp 3577 1 As as IN cord-015306-us58wwmp 3577 2 expected expect VBN cord-015306-us58wwmp 3577 3 patients patient NNS cord-015306-us58wwmp 3577 4 ' ' POS cord-015306-us58wwmp 3577 5 characteristics characteristic NNS cord-015306-us58wwmp 3577 6 contribute contribute VBP cord-015306-us58wwmp 3577 7 to to IN cord-015306-us58wwmp 3577 8 intercenter intercenter JJ cord-015306-us58wwmp 3577 9 variability variability NN cord-015306-us58wwmp 3577 10 as as RB cord-015306-us58wwmp 3577 11 well well RB cord-015306-us58wwmp 3577 12 as as IN cord-015306-us58wwmp 3577 13 centers center NNS cord-015306-us58wwmp 3577 14 ' ' POS cord-015306-us58wwmp 3577 15 attitude attitude NN cord-015306-us58wwmp 3577 16 towards towards IN cord-015306-us58wwmp 3577 17 the the DT cord-015306-us58wwmp 3577 18 inscription inscription NN cord-015306-us58wwmp 3577 19 of of IN cord-015306-us58wwmp 3577 20 younger young JJR cord-015306-us58wwmp 3577 21 children child NNS cord-015306-us58wwmp 3577 22 , , , cord-015306-us58wwmp 3577 23 management management NN cord-015306-us58wwmp 3577 24 of of IN cord-015306-us58wwmp 3577 25 specific specific JJ cord-015306-us58wwmp 3577 26 primary primary JJ cord-015306-us58wwmp 3577 27 renal renal JJ cord-015306-us58wwmp 3577 28 diseases disease NNS cord-015306-us58wwmp 3577 29 and and CC cord-015306-us58wwmp 3577 30 preemptive preemptive JJ cord-015306-us58wwmp 3577 31 transplantation transplantation NN cord-015306-us58wwmp 3577 32 . . . cord-015306-us58wwmp 3578 1 Despite despite IN cord-015306-us58wwmp 3578 2 national national JJ cord-015306-us58wwmp 3578 3 allocation allocation NN cord-015306-us58wwmp 3578 4 rules rule NNS cord-015306-us58wwmp 3578 5 we -PRON- PRP cord-015306-us58wwmp 3578 6 found find VBD cord-015306-us58wwmp 3578 7 a a DT cord-015306-us58wwmp 3578 8 significant significant JJ cord-015306-us58wwmp 3578 9 inter inter JJ cord-015306-us58wwmp 3578 10 - - JJ cord-015306-us58wwmp 3578 11 center center JJ cord-015306-us58wwmp 3578 12 variability variability NN cord-015306-us58wwmp 3578 13 in in IN cord-015306-us58wwmp 3578 14 the the DT cord-015306-us58wwmp 3578 15 probability probability NN cord-015306-us58wwmp 3578 16 of of IN cord-015306-us58wwmp 3578 17 being be VBG cord-015306-us58wwmp 3578 18 transplanted transplant VBN cord-015306-us58wwmp 3578 19 after after IN cord-015306-us58wwmp 3578 20 inscription inscription NN cord-015306-us58wwmp 3578 21 on on IN cord-015306-us58wwmp 3578 22 the the DT cord-015306-us58wwmp 3578 23 list list NN cord-015306-us58wwmp 3578 24 , , , cord-015306-us58wwmp 3578 25 which which WDT cord-015306-us58wwmp 3578 26 was be VBD cord-015306-us58wwmp 3578 27 not not RB cord-015306-us58wwmp 3578 28 explained explain VBN cord-015306-us58wwmp 3578 29 by by IN cord-015306-us58wwmp 3578 30 either either CC cord-015306-us58wwmp 3578 31 the the DT cord-015306-us58wwmp 3578 32 patient patient NN cord-015306-us58wwmp 3578 33 or or CC cord-015306-us58wwmp 3578 34 center center NN cord-015306-us58wwmp 3578 35 characteristics characteristic NNS cord-015306-us58wwmp 3578 36 of of IN cord-015306-us58wwmp 3578 37 our -PRON- PRP$ cord-015306-us58wwmp 3578 38 study study NN cord-015306-us58wwmp 3578 39 . . . cord-015306-us58wwmp 3579 1 Abstract abstract JJ cord-015306-us58wwmp 3579 2 # # NN cord-015306-us58wwmp 3580 1 P p NN cord-015306-us58wwmp 3580 2 - - : cord-015306-us58wwmp 3580 3 SAT414 SAT414 NNP cord-015306-us58wwmp 3581 1 Ten ten CD cord-015306-us58wwmp 3581 2 year year NN cord-015306-us58wwmp 3581 3 outcomes outcome NNS cord-015306-us58wwmp 3581 4 of of IN cord-015306-us58wwmp 3581 5 paediatric paediatric JJ cord-015306-us58wwmp 3581 6 renal renal JJ cord-015306-us58wwmp 3581 7 transplantation transplantation NN cord-015306-us58wwmp 3581 8 : : : cord-015306-us58wwmp 3582 1 the the DT cord-015306-us58wwmp 3582 2 Irish irish JJ cord-015306-us58wwmp 3582 3 experience experience NN cord-015306-us58wwmp 3582 4 Objective objective NN cord-015306-us58wwmp 3582 5 : : : cord-015306-us58wwmp 3583 1 Focal focal JJ cord-015306-us58wwmp 3583 2 segmental segmental JJ cord-015306-us58wwmp 3583 3 glomerulosclerosis glomerulosclerosis NN cord-015306-us58wwmp 3583 4 is be VBZ cord-015306-us58wwmp 3583 5 the the DT cord-015306-us58wwmp 3583 6 most most RBS cord-015306-us58wwmp 3583 7 common common JJ cord-015306-us58wwmp 3583 8 cause cause NN cord-015306-us58wwmp 3583 9 of of IN cord-015306-us58wwmp 3583 10 steroid steroid NN cord-015306-us58wwmp 3583 11 - - HYPH cord-015306-us58wwmp 3583 12 resistant resistant JJ cord-015306-us58wwmp 3583 13 nephrotic nephrotic JJ cord-015306-us58wwmp 3583 14 syndrome syndrome NN cord-015306-us58wwmp 3583 15 in in IN cord-015306-us58wwmp 3583 16 children child NNS cord-015306-us58wwmp 3583 17 and and CC cord-015306-us58wwmp 3583 18 adolescents adolescent NNS cord-015306-us58wwmp 3583 19 . . . cord-015306-us58wwmp 3584 1 Within within IN cord-015306-us58wwmp 3584 2 10 10 CD cord-015306-us58wwmp 3584 3 years year NNS cord-015306-us58wwmp 3584 4 of of IN cord-015306-us58wwmp 3584 5 initial initial JJ cord-015306-us58wwmp 3584 6 presentation presentation NN cord-015306-us58wwmp 3584 7 , , , cord-015306-us58wwmp 3584 8 50 50 CD cord-015306-us58wwmp 3584 9 - - SYM cord-015306-us58wwmp 3584 10 70 70 CD cord-015306-us58wwmp 3584 11 % % NN cord-015306-us58wwmp 3584 12 of of IN cord-015306-us58wwmp 3584 13 patients patient NNS cord-015306-us58wwmp 3584 14 will will MD cord-015306-us58wwmp 3584 15 progress progress VB cord-015306-us58wwmp 3584 16 to to TO cord-015306-us58wwmp 3584 17 end end VB cord-015306-us58wwmp 3584 18 stage stage NN cord-015306-us58wwmp 3584 19 kidney kidney NN cord-015306-us58wwmp 3584 20 disease disease NN cord-015306-us58wwmp 3584 21 requiring require VBG cord-015306-us58wwmp 3584 22 kidney kidney NN cord-015306-us58wwmp 3584 23 transplant transplant NN cord-015306-us58wwmp 3584 24 . . . cord-015306-us58wwmp 3585 1 Recurrence recurrence NN cord-015306-us58wwmp 3585 2 rate rate NN cord-015306-us58wwmp 3585 3 after after IN cord-015306-us58wwmp 3585 4 transplantation transplantation NN cord-015306-us58wwmp 3585 5 is be VBZ cord-015306-us58wwmp 3585 6 high high JJ cord-015306-us58wwmp 3585 7 and and CC cord-015306-us58wwmp 3585 8 may may MD cord-015306-us58wwmp 3585 9 be be VB cord-015306-us58wwmp 3585 10 associated associate VBN cord-015306-us58wwmp 3585 11 with with IN cord-015306-us58wwmp 3585 12 early early JJ cord-015306-us58wwmp 3585 13 graft graft NN cord-015306-us58wwmp 3585 14 loss loss NN cord-015306-us58wwmp 3585 15 . . . cord-015306-us58wwmp 3586 1 Methods method NNS cord-015306-us58wwmp 3586 2 : : : cord-015306-us58wwmp 3587 1 We -PRON- PRP cord-015306-us58wwmp 3587 2 analysed analyse VBD cord-015306-us58wwmp 3587 3 demographic demographic JJ cord-015306-us58wwmp 3587 4 and and CC cord-015306-us58wwmp 3587 5 transplant transplant NN cord-015306-us58wwmp 3587 6 data datum NNS cord-015306-us58wwmp 3587 7 collected collect VBN cord-015306-us58wwmp 3587 8 by by IN cord-015306-us58wwmp 3587 9 the the DT cord-015306-us58wwmp 3587 10 Australian australian JJ cord-015306-us58wwmp 3587 11 and and CC cord-015306-us58wwmp 3587 12 New New NNP cord-015306-us58wwmp 3587 13 Zealand Zealand NNP cord-015306-us58wwmp 3587 14 Dialysis Dialysis NNP cord-015306-us58wwmp 3587 15 and and CC cord-015306-us58wwmp 3587 16 Transplant Transplant NNP cord-015306-us58wwmp 3587 17 Registry Registry NNP cord-015306-us58wwmp 3587 18 ( ( -LRB- cord-015306-us58wwmp 3587 19 ANZDATA ANZDATA NNP cord-015306-us58wwmp 3587 20 ) ) -RRB- cord-015306-us58wwmp 3587 21 on on IN cord-015306-us58wwmp 3587 22 children child NNS cord-015306-us58wwmp 3587 23 and and CC cord-015306-us58wwmp 3587 24 adolescents adolescent NNS cord-015306-us58wwmp 3587 25 with with IN cord-015306-us58wwmp 3587 26 a a DT cord-015306-us58wwmp 3587 27 diagnosis diagnosis NN cord-015306-us58wwmp 3587 28 of of IN cord-015306-us58wwmp 3587 29 primary primary JJ cord-015306-us58wwmp 3587 30 FSGS FSGS NNP cord-015306-us58wwmp 3587 31 who who WP cord-015306-us58wwmp 3587 32 were be VBD cord-015306-us58wwmp 3587 33 20 20 CD cord-015306-us58wwmp 3587 34 years year NNS cord-015306-us58wwmp 3587 35 of of IN cord-015306-us58wwmp 3587 36 age age NN cord-015306-us58wwmp 3587 37 or or CC cord-015306-us58wwmp 3587 38 younger young JJR cord-015306-us58wwmp 3587 39 at at IN cord-015306-us58wwmp 3587 40 the the DT cord-015306-us58wwmp 3587 41 time time NN cord-015306-us58wwmp 3587 42 of of IN cord-015306-us58wwmp 3587 43 transplant transplant NN cord-015306-us58wwmp 3587 44 . . . cord-015306-us58wwmp 3588 1 Kaplan Kaplan NNP cord-015306-us58wwmp 3588 2 - - HYPH cord-015306-us58wwmp 3588 3 Meier Meier NNP cord-015306-us58wwmp 3588 4 analysis analysis NN cord-015306-us58wwmp 3588 5 was be VBD cord-015306-us58wwmp 3588 6 performed perform VBN cord-015306-us58wwmp 3588 7 to to TO cord-015306-us58wwmp 3588 8 compare compare VB cord-015306-us58wwmp 3588 9 graft graft NN cord-015306-us58wwmp 3588 10 survival survival NN cord-015306-us58wwmp 3588 11 according accord VBG cord-015306-us58wwmp 3588 12 to to IN cord-015306-us58wwmp 3588 13 recurrence recurrence NN cord-015306-us58wwmp 3588 14 of of IN cord-015306-us58wwmp 3588 15 FSGS FSGS NNP cord-015306-us58wwmp 3588 16 and and CC cord-015306-us58wwmp 3588 17 donor donor NN cord-015306-us58wwmp 3588 18 characteristics characteristic NNS cord-015306-us58wwmp 3588 19 . . . cord-015306-us58wwmp 3589 1 Results result NNS cord-015306-us58wwmp 3589 2 : : : cord-015306-us58wwmp 3590 1 During during IN cord-015306-us58wwmp 3590 2 the the DT cord-015306-us58wwmp 3590 3 20-year 20-year JJ cord-015306-us58wwmp 3590 4 period period NN cord-015306-us58wwmp 3590 5 from from IN cord-015306-us58wwmp 3590 6 1st 1st JJ cord-015306-us58wwmp 3590 7 January January NNP cord-015306-us58wwmp 3590 8 1992 1992 CD cord-015306-us58wwmp 3590 9 to to IN cord-015306-us58wwmp 3590 10 31st 31st NN cord-015306-us58wwmp 3590 11 December December NNP cord-015306-us58wwmp 3590 12 2011 2011 CD cord-015306-us58wwmp 3590 13 , , , cord-015306-us58wwmp 3590 14 80 80 CD cord-015306-us58wwmp 3590 15 transplants transplant NNS cord-015306-us58wwmp 3590 16 were be VBD cord-015306-us58wwmp 3590 17 performed perform VBN cord-015306-us58wwmp 3590 18 in in IN cord-015306-us58wwmp 3590 19 74 74 CD cord-015306-us58wwmp 3590 20 patients patient NNS cord-015306-us58wwmp 3590 21 ( ( -LRB- cord-015306-us58wwmp 3590 22 age age NN cord-015306-us58wwmp 3590 23 range range NN cord-015306-us58wwmp 3590 24 3 3 CD cord-015306-us58wwmp 3590 25 - - SYM cord-015306-us58wwmp 3590 26 20 20 CD cord-015306-us58wwmp 3590 27 years year NNS cord-015306-us58wwmp 3590 28 , , , cord-015306-us58wwmp 3590 29 median median NN cord-015306-us58wwmp 3590 30 15 15 CD cord-015306-us58wwmp 3590 31 years year NNS cord-015306-us58wwmp 3590 32 ) ) -RRB- cord-015306-us58wwmp 3590 33 . . . cord-015306-us58wwmp 3591 1 Twenty twenty CD cord-015306-us58wwmp 3591 2 seven seven CD cord-015306-us58wwmp 3591 3 patients patient NNS cord-015306-us58wwmp 3591 4 developed develop VBD cord-015306-us58wwmp 3591 5 recurrent recurrent JJ cord-015306-us58wwmp 3591 6 FSGS FSGS NNP cord-015306-us58wwmp 3591 7 , , , cord-015306-us58wwmp 3591 8 with with IN cord-015306-us58wwmp 3591 9 one one CD cord-015306-us58wwmp 3591 10 child child NN cord-015306-us58wwmp 3591 11 developing develop VBG cord-015306-us58wwmp 3591 12 recurrent recurrent JJ cord-015306-us58wwmp 3591 13 disease disease NN cord-015306-us58wwmp 3591 14 in in IN cord-015306-us58wwmp 3591 15 2 2 CD cord-015306-us58wwmp 3591 16 grafts graft NNS cord-015306-us58wwmp 3591 17 ( ( -LRB- cord-015306-us58wwmp 3591 18 overall overall JJ cord-015306-us58wwmp 3591 19 recurrence recurrence NN cord-015306-us58wwmp 3591 20 rate rate NN cord-015306-us58wwmp 3591 21 36 36 CD cord-015306-us58wwmp 3591 22 % % NN cord-015306-us58wwmp 3591 23 ) ) -RRB- cord-015306-us58wwmp 3591 24 . . . cord-015306-us58wwmp 3592 1 The the DT cord-015306-us58wwmp 3592 2 median median JJ cord-015306-us58wwmp 3592 3 time time NN cord-015306-us58wwmp 3592 4 to to IN cord-015306-us58wwmp 3592 5 recurrence recurrence NN cord-015306-us58wwmp 3592 6 was be VBD cord-015306-us58wwmp 3592 7 15 15 CD cord-015306-us58wwmp 3592 8 days day NNS cord-015306-us58wwmp 3592 9 , , , cord-015306-us58wwmp 3592 10 with with IN cord-015306-us58wwmp 3592 11 loss loss NN cord-015306-us58wwmp 3592 12 of of IN cord-015306-us58wwmp 3592 13 graft graft NN cord-015306-us58wwmp 3592 14 function function NN cord-015306-us58wwmp 3592 15 in in IN cord-015306-us58wwmp 3592 16 12/28 12/28 CD cord-015306-us58wwmp 3592 17 transplants transplant NNS cord-015306-us58wwmp 3592 18 ( ( -LRB- cord-015306-us58wwmp 3592 19 43 43 CD cord-015306-us58wwmp 3592 20 % % NN cord-015306-us58wwmp 3592 21 ) ) -RRB- cord-015306-us58wwmp 3592 22 . . . cord-015306-us58wwmp 3593 1 Median median JJ cord-015306-us58wwmp 3593 2 graft graft NN cord-015306-us58wwmp 3593 3 survival survival NN cord-015306-us58wwmp 3593 4 in in IN cord-015306-us58wwmp 3593 5 patients patient NNS cord-015306-us58wwmp 3593 6 with with IN cord-015306-us58wwmp 3593 7 recurrence recurrence NN cord-015306-us58wwmp 3593 8 was be VBD cord-015306-us58wwmp 3593 9 significantly significantly RB cord-015306-us58wwmp 3593 10 shorter short JJR cord-015306-us58wwmp 3593 11 than than IN cord-015306-us58wwmp 3593 12 in in IN cord-015306-us58wwmp 3593 13 patients patient NNS cord-015306-us58wwmp 3593 14 with with IN cord-015306-us58wwmp 3593 15 no no DT cord-015306-us58wwmp 3593 16 recurrence recurrence NN cord-015306-us58wwmp 3593 17 ( ( -LRB- cord-015306-us58wwmp 3593 18 2.3 2.3 CD cord-015306-us58wwmp 3593 19 years year NNS cord-015306-us58wwmp 3593 20 vs vs IN cord-015306-us58wwmp 3593 21 > > XX cord-015306-us58wwmp 3593 22 10 10 CD cord-015306-us58wwmp 3593 23 years year NNS cord-015306-us58wwmp 3593 24 , , , cord-015306-us58wwmp 3593 25 respectively respectively RB cord-015306-us58wwmp 3593 26 ; ; : cord-015306-us58wwmp 3593 27 p<0.01 p<0.01 NNP cord-015306-us58wwmp 3593 28 ) ) -RRB- cord-015306-us58wwmp 3593 29 . . . cord-015306-us58wwmp 3594 1 There there EX cord-015306-us58wwmp 3594 2 was be VBD cord-015306-us58wwmp 3594 3 no no DT cord-015306-us58wwmp 3594 4 significant significant JJ cord-015306-us58wwmp 3594 5 difference difference NN cord-015306-us58wwmp 3594 6 in in IN cord-015306-us58wwmp 3594 7 recurrence recurrence NN cord-015306-us58wwmp 3594 8 rate rate NN cord-015306-us58wwmp 3594 9 in in IN cord-015306-us58wwmp 3594 10 recipients recipient NNS cord-015306-us58wwmp 3594 11 receiving receive VBG cord-015306-us58wwmp 3594 12 deceased deceased JJ cord-015306-us58wwmp 3594 13 donor donor NN cord-015306-us58wwmp 3594 14 ( ( -LRB- cord-015306-us58wwmp 3594 15 DD DD NNP cord-015306-us58wwmp 3594 16 ) ) -RRB- cord-015306-us58wwmp 3594 17 versus versus IN cord-015306-us58wwmp 3594 18 live live JJ cord-015306-us58wwmp 3594 19 donor donor NN cord-015306-us58wwmp 3594 20 ( ( -LRB- cord-015306-us58wwmp 3594 21 LD LD NNP cord-015306-us58wwmp 3594 22 ) ) -RRB- cord-015306-us58wwmp 3594 23 transplants transplant NNS cord-015306-us58wwmp 3594 24 ( ( -LRB- cord-015306-us58wwmp 3594 25 p=0.24 p=0.24 NNP cord-015306-us58wwmp 3594 26 ) ) -RRB- cord-015306-us58wwmp 3594 27 and and CC cord-015306-us58wwmp 3594 28 median median JJ cord-015306-us58wwmp 3594 29 graft graft NN cord-015306-us58wwmp 3594 30 survival survival NN cord-015306-us58wwmp 3594 31 was be VBD cord-015306-us58wwmp 3594 32 significantly significantly RB cord-015306-us58wwmp 3594 33 better well JJR cord-015306-us58wwmp 3594 34 in in IN cord-015306-us58wwmp 3594 35 recipients recipient NNS cord-015306-us58wwmp 3594 36 with with IN cord-015306-us58wwmp 3594 37 live live JJ cord-015306-us58wwmp 3594 38 donors donor NNS cord-015306-us58wwmp 3594 39 ( ( -LRB- cord-015306-us58wwmp 3594 40 11.7 11.7 CD cord-015306-us58wwmp 3594 41 yrs yr NNS cord-015306-us58wwmp 3594 42 vs vs IN cord-015306-us58wwmp 3594 43 1.6 1.6 CD cord-015306-us58wwmp 3594 44 yrs yr NNS cord-015306-us58wwmp 3594 45 for for IN cord-015306-us58wwmp 3594 46 DD DD NNP cord-015306-us58wwmp 3594 47 , , , cord-015306-us58wwmp 3594 48 p<0.01 p<0.01 NN cord-015306-us58wwmp 3594 49 ) ) -RRB- cord-015306-us58wwmp 3595 1 Conclusion conclusion NN cord-015306-us58wwmp 3595 2 : : : cord-015306-us58wwmp 3596 1 The the DT cord-015306-us58wwmp 3596 2 rate rate NN cord-015306-us58wwmp 3596 3 of of IN cord-015306-us58wwmp 3596 4 recurrent recurrent JJ cord-015306-us58wwmp 3596 5 FSGS fsgs NN cord-015306-us58wwmp 3596 6 and and CC cord-015306-us58wwmp 3596 7 graft graft NN cord-015306-us58wwmp 3596 8 loss loss NN cord-015306-us58wwmp 3596 9 in in IN cord-015306-us58wwmp 3596 10 this this DT cord-015306-us58wwmp 3596 11 retrospective retrospective JJ cord-015306-us58wwmp 3596 12 cohort cohort NN cord-015306-us58wwmp 3596 13 study study NN cord-015306-us58wwmp 3596 14 of of IN cord-015306-us58wwmp 3596 15 children child NNS cord-015306-us58wwmp 3596 16 and and CC cord-015306-us58wwmp 3596 17 adolescents adolescent NNS cord-015306-us58wwmp 3596 18 transplanted transplant VBN cord-015306-us58wwmp 3596 19 within within IN cord-015306-us58wwmp 3596 20 the the DT cord-015306-us58wwmp 3596 21 Australasian australasian JJ cord-015306-us58wwmp 3596 22 region region NN cord-015306-us58wwmp 3596 23 , , , cord-015306-us58wwmp 3596 24 was be VBD cord-015306-us58wwmp 3596 25 similar similar JJ cord-015306-us58wwmp 3596 26 to to IN cord-015306-us58wwmp 3596 27 previously previously RB cord-015306-us58wwmp 3596 28 reported report VBN cord-015306-us58wwmp 3596 29 studies study NNS cord-015306-us58wwmp 3596 30 . . . cord-015306-us58wwmp 3597 1 However however RB cord-015306-us58wwmp 3597 2 , , , cord-015306-us58wwmp 3597 3 in in IN cord-015306-us58wwmp 3597 4 contrast contrast NN cord-015306-us58wwmp 3597 5 to to IN cord-015306-us58wwmp 3597 6 previous previous JJ cord-015306-us58wwmp 3597 7 studies study NNS cord-015306-us58wwmp 3597 8 , , , cord-015306-us58wwmp 3597 9 there there EX cord-015306-us58wwmp 3597 10 was be VBD cord-015306-us58wwmp 3597 11 no no DT cord-015306-us58wwmp 3597 12 significant significant JJ cord-015306-us58wwmp 3597 13 difference difference NN cord-015306-us58wwmp 3597 14 in in IN cord-015306-us58wwmp 3597 15 rate rate NN cord-015306-us58wwmp 3597 16 of of IN cord-015306-us58wwmp 3597 17 recurrence recurrence NN cord-015306-us58wwmp 3597 18 for for IN cord-015306-us58wwmp 3597 19 live live JJ cord-015306-us58wwmp 3597 20 versus versus IN cord-015306-us58wwmp 3597 21 deceased deceased JJ cord-015306-us58wwmp 3597 22 donors donor NNS cord-015306-us58wwmp 3597 23 . . . cord-015306-us58wwmp 3598 1 Additionally additionally RB cord-015306-us58wwmp 3598 2 , , , cord-015306-us58wwmp 3598 3 live live JJ cord-015306-us58wwmp 3598 4 donor donor NN cord-015306-us58wwmp 3598 5 recipients recipient NNS cord-015306-us58wwmp 3598 6 had have VBD cord-015306-us58wwmp 3598 7 longer long JJR cord-015306-us58wwmp 3598 8 median median JJ cord-015306-us58wwmp 3598 9 graft graft NN cord-015306-us58wwmp 3598 10 survival survival NN cord-015306-us58wwmp 3598 11 compared compare VBN cord-015306-us58wwmp 3598 12 to to IN cord-015306-us58wwmp 3598 13 deceased deceased JJ cord-015306-us58wwmp 3598 14 donor donor NN cord-015306-us58wwmp 3598 15 recipients recipient NNS cord-015306-us58wwmp 3598 16 . . . cord-015306-us58wwmp 3599 1 Outcomes outcome NNS cord-015306-us58wwmp 3599 2 of of IN cord-015306-us58wwmp 3599 3 calcineurin calcineurin NNP cord-015306-us58wwmp 3599 4 inhibitors inhibitor NNS cord-015306-us58wwmp 3599 5 conversion conversion NN cord-015306-us58wwmp 3599 6 to to IN cord-015306-us58wwmp 3599 7 mammalian mammalian JJ cord-015306-us58wwmp 3599 8 target target NN cord-015306-us58wwmp 3599 9 of of IN cord-015306-us58wwmp 3599 10 rapamycin rapamycin NN cord-015306-us58wwmp 3599 11 inhibitors inhibitor NNS cord-015306-us58wwmp 3599 12 in in IN cord-015306-us58wwmp 3599 13 children child NNS cord-015306-us58wwmp 3599 14 with with IN cord-015306-us58wwmp 3599 15 renal renal JJ cord-015306-us58wwmp 3599 16 transplantation transplantation NN cord-015306-us58wwmp 3599 17 Nuntawan Nuntawan NNP cord-015306-us58wwmp 3599 18 Piyaphanee Piyaphanee NNP cord-015306-us58wwmp 3599 19 , , , cord-015306-us58wwmp 3599 20 Suroj Suroj NNP cord-015306-us58wwmp 3599 21 Supavekin Supavekin NNP cord-015306-us58wwmp 3599 22 , , , cord-015306-us58wwmp 3599 23 Anirut Anirut NNP cord-015306-us58wwmp 3599 24 Pattaragarn Pattaragarn NNP cord-015306-us58wwmp 3599 25 Pediatrics Pediatrics NNP cord-015306-us58wwmp 3599 26 , , , cord-015306-us58wwmp 3599 27 Siriaj Siriaj NNP cord-015306-us58wwmp 3599 28 Hospital Hospital NNP cord-015306-us58wwmp 3599 29 , , , cord-015306-us58wwmp 3599 30 Bangkok Bangkok NNP cord-015306-us58wwmp 3599 31 , , , cord-015306-us58wwmp 3600 1 Thailand Thailand NNP cord-015306-us58wwmp 3600 2 Objective Objective NNP cord-015306-us58wwmp 3600 3 : : : cord-015306-us58wwmp 3601 1 To to TO cord-015306-us58wwmp 3601 2 study study VB cord-015306-us58wwmp 3601 3 outcomes outcome NNS cord-015306-us58wwmp 3601 4 of of IN cord-015306-us58wwmp 3601 5 pediatric pediatric JJ cord-015306-us58wwmp 3601 6 renal renal JJ cord-015306-us58wwmp 3601 7 transplant transplant NN cord-015306-us58wwmp 3601 8 recipients recipient NNS cord-015306-us58wwmp 3601 9 who who WP cord-015306-us58wwmp 3601 10 underwent undergo VBD cord-015306-us58wwmp 3601 11 CNI CNI NNP cord-015306-us58wwmp 3601 12 elimination elimination NN cord-015306-us58wwmp 3601 13 and and CC cord-015306-us58wwmp 3601 14 conversion conversion NN cord-015306-us58wwmp 3601 15 to to IN cord-015306-us58wwmp 3601 16 mTOR mTOR NNP cord-015306-us58wwmp 3601 17 inhibitors inhibitor NNS cord-015306-us58wwmp 3601 18 . . . cord-015306-us58wwmp 3602 1 Methods method NNS cord-015306-us58wwmp 3602 2 : : : cord-015306-us58wwmp 3602 3 We -PRON- PRP cord-015306-us58wwmp 3602 4 performed perform VBD cord-015306-us58wwmp 3602 5 retrospective retrospective JJ cord-015306-us58wwmp 3602 6 analysis analysis NN cord-015306-us58wwmp 3602 7 of of IN cord-015306-us58wwmp 3602 8 all all DT cord-015306-us58wwmp 3602 9 pediatric pediatric JJ cord-015306-us58wwmp 3602 10 renal renal JJ cord-015306-us58wwmp 3602 11 transplant transplant NN cord-015306-us58wwmp 3602 12 recipients recipient NNS cord-015306-us58wwmp 3602 13 who who WP cord-015306-us58wwmp 3602 14 underwent undergo VBD cord-015306-us58wwmp 3602 15 CNI CNI NNP cord-015306-us58wwmp 3602 16 elimination elimination NN cord-015306-us58wwmp 3602 17 and and CC cord-015306-us58wwmp 3602 18 conversion conversion NN cord-015306-us58wwmp 3602 19 to to IN cord-015306-us58wwmp 3602 20 mTOR mTOR NNP cord-015306-us58wwmp 3602 21 inhibitor inhibitor NN cord-015306-us58wwmp 3602 22 at at IN cord-015306-us58wwmp 3602 23 Siriraj Siriraj NNP cord-015306-us58wwmp 3602 24 Hospital Hospital NNP cord-015306-us58wwmp 3602 25 , , , cord-015306-us58wwmp 3602 26 a a DT cord-015306-us58wwmp 3602 27 tertiary tertiary JJ cord-015306-us58wwmp 3602 28 care care NN cord-015306-us58wwmp 3602 29 center center NN cord-015306-us58wwmp 3602 30 in in IN cord-015306-us58wwmp 3602 31 Thailand Thailand NNP cord-015306-us58wwmp 3602 32 . . . cord-015306-us58wwmp 3603 1 Indications indication NNS cord-015306-us58wwmp 3603 2 for for IN cord-015306-us58wwmp 3603 3 conversion conversion NN cord-015306-us58wwmp 3603 4 were be VBD cord-015306-us58wwmp 3603 5 defined define VBN cord-015306-us58wwmp 3603 6 . . . cord-015306-us58wwmp 3604 1 Graft graft NN cord-015306-us58wwmp 3604 2 function function NN cord-015306-us58wwmp 3604 3 prior prior RB cord-015306-us58wwmp 3604 4 and and CC cord-015306-us58wwmp 3604 5 post post NN cord-015306-us58wwmp 3604 6 conversion conversion NN cord-015306-us58wwmp 3604 7 , , , cord-015306-us58wwmp 3604 8 history history NN cord-015306-us58wwmp 3604 9 of of IN cord-015306-us58wwmp 3604 10 acute acute JJ cord-015306-us58wwmp 3604 11 rejection rejection NN cord-015306-us58wwmp 3604 12 , , , cord-015306-us58wwmp 3604 13 and and CC cord-015306-us58wwmp 3604 14 CNI CNI NNP cord-015306-us58wwmp 3604 15 elimination elimination NN cord-015306-us58wwmp 3604 16 failure failure NN cord-015306-us58wwmp 3604 17 were be VBD cord-015306-us58wwmp 3604 18 reviewed review VBN cord-015306-us58wwmp 3604 19 . . . cord-015306-us58wwmp 3605 1 Results result NNS cord-015306-us58wwmp 3605 2 : : : cord-015306-us58wwmp 3606 1 Nine nine CD cord-015306-us58wwmp 3606 2 of of IN cord-015306-us58wwmp 3606 3 32 32 CD cord-015306-us58wwmp 3606 4 pediatric pediatric JJ cord-015306-us58wwmp 3606 5 renal renal JJ cord-015306-us58wwmp 3606 6 transplant transplant NN cord-015306-us58wwmp 3606 7 recipients recipient NNS cord-015306-us58wwmp 3606 8 underwent undergo VBD cord-015306-us58wwmp 3606 9 complete complete JJ cord-015306-us58wwmp 3606 10 CNI CNI NNP cord-015306-us58wwmp 3606 11 conversion conversion NN cord-015306-us58wwmp 3606 12 to to IN cord-015306-us58wwmp 3606 13 mTOR mTOR NNP cord-015306-us58wwmp 3606 14 inhibitor inhibitor NN cord-015306-us58wwmp 3606 15 . . . cord-015306-us58wwmp 3607 1 Triple triple JJ cord-015306-us58wwmp 3607 2 - - HYPH cord-015306-us58wwmp 3607 3 drug drug NN cord-015306-us58wwmp 3607 4 regimen regimen NN cord-015306-us58wwmp 3607 5 including include VBG cord-015306-us58wwmp 3607 6 prednisolone prednisolone NN cord-015306-us58wwmp 3607 7 , , , cord-015306-us58wwmp 3607 8 CNI CNI NNP cord-015306-us58wwmp 3607 9 and and CC cord-015306-us58wwmp 3607 10 MMF MMF NNP cord-015306-us58wwmp 3607 11 / / SYM cord-015306-us58wwmp 3607 12 MPA MPA NNP cord-015306-us58wwmp 3607 13 was be VBD cord-015306-us58wwmp 3607 14 basically basically RB cord-015306-us58wwmp 3607 15 prescribed prescribe VBN cord-015306-us58wwmp 3607 16 to to IN cord-015306-us58wwmp 3607 17 the the DT cord-015306-us58wwmp 3607 18 recipients recipient NNS cord-015306-us58wwmp 3607 19 . . . cord-015306-us58wwmp 3608 1 Eight eight CD cord-015306-us58wwmp 3608 2 with with IN cord-015306-us58wwmp 3608 3 tacrolimus tacrolimus NN cord-015306-us58wwmp 3608 4 and and CC cord-015306-us58wwmp 3608 5 1 1 CD cord-015306-us58wwmp 3608 6 with with IN cord-015306-us58wwmp 3608 7 cyclosporine cyclosporine NN cord-015306-us58wwmp 3608 8 were be VBD cord-015306-us58wwmp 3608 9 conversed converse VBN cord-015306-us58wwmp 3608 10 to to IN cord-015306-us58wwmp 3608 11 everolimus everolimus NNP cord-015306-us58wwmp 3608 12 . . . cord-015306-us58wwmp 3609 1 Mean mean JJ cord-015306-us58wwmp 3609 2 ages age NNS cord-015306-us58wwmp 3609 3 at at IN cord-015306-us58wwmp 3609 4 transplantation transplantation NN cord-015306-us58wwmp 3609 5 , , , cord-015306-us58wwmp 3609 6 conversion conversion NN cord-015306-us58wwmp 3609 7 and and CC cord-015306-us58wwmp 3609 8 last last JJ cord-015306-us58wwmp 3609 9 follow follow NN cord-015306-us58wwmp 3609 10 up up RB cord-015306-us58wwmp 3609 11 were be VBD cord-015306-us58wwmp 3609 12 12.1±2.4 12.1±2.4 CD cord-015306-us58wwmp 3609 13 , , , cord-015306-us58wwmp 3609 14 13.6±2.1 13.6±2.1 CD cord-015306-us58wwmp 3609 15 and and CC cord-015306-us58wwmp 3609 16 14.5±1.8 14.5±1.8 CD cord-015306-us58wwmp 3609 17 years year NNS cord-015306-us58wwmp 3609 18 , , , cord-015306-us58wwmp 3609 19 respectively respectively RB cord-015306-us58wwmp 3609 20 . . . cord-015306-us58wwmp 3610 1 Everolimus Everolimus NNP cord-015306-us58wwmp 3610 2 was be VBD cord-015306-us58wwmp 3610 3 initiated initiate VBN cord-015306-us58wwmp 3610 4 within within IN cord-015306-us58wwmp 3610 5 3 3 CD cord-015306-us58wwmp 3610 6 months month NNS cord-015306-us58wwmp 3610 7 in in IN cord-015306-us58wwmp 3610 8 4 4 CD cord-015306-us58wwmp 3610 9 patients patient NNS cord-015306-us58wwmp 3610 10 . . . cord-015306-us58wwmp 3611 1 Each each DT cord-015306-us58wwmp 3611 2 patient patient NN cord-015306-us58wwmp 3611 3 due due IN cord-015306-us58wwmp 3611 4 to to IN cord-015306-us58wwmp 3611 5 CNI CNI NNP cord-015306-us58wwmp 3611 6 induced induce VBN cord-015306-us58wwmp 3611 7 hemolytic hemolytic JJ cord-015306-us58wwmp 3611 8 uremic uremic JJ cord-015306-us58wwmp 3611 9 syndrome syndrome NN cord-015306-us58wwmp 3611 10 , , , cord-015306-us58wwmp 3611 11 posttransplant posttransplant NNP cord-015306-us58wwmp 3611 12 diabetes diabetes NN cord-015306-us58wwmp 3611 13 mellitus mellitus NN cord-015306-us58wwmp 3611 14 , , , cord-015306-us58wwmp 3611 15 graft graft NN cord-015306-us58wwmp 3611 16 impairment impairment NN cord-015306-us58wwmp 3611 17 with with IN cord-015306-us58wwmp 3611 18 early early JJ cord-015306-us58wwmp 3611 19 onset onset NN cord-015306-us58wwmp 3611 20 nephrocalcinosis nephrocalcinosis NN cord-015306-us58wwmp 3611 21 and and CC cord-015306-us58wwmp 3611 22 graft graft NN cord-015306-us58wwmp 3611 23 impairment impairment NN cord-015306-us58wwmp 3611 24 with with IN cord-015306-us58wwmp 3611 25 renal renal JJ cord-015306-us58wwmp 3611 26 artery artery NN cord-015306-us58wwmp 3611 27 stenosis stenosis NN cord-015306-us58wwmp 3611 28 . . . cord-015306-us58wwmp 3612 1 Everolimus Everolimus NNP cord-015306-us58wwmp 3612 2 was be VBD cord-015306-us58wwmp 3612 3 initiated initiate VBN cord-015306-us58wwmp 3612 4 after after IN cord-015306-us58wwmp 3612 5 3 3 CD cord-015306-us58wwmp 3612 6 months month NNS cord-015306-us58wwmp 3612 7 in in IN cord-015306-us58wwmp 3612 8 5 5 CD cord-015306-us58wwmp 3612 9 patients patient NNS cord-015306-us58wwmp 3612 10 due due JJ cord-015306-us58wwmp 3612 11 to to IN cord-015306-us58wwmp 3612 12 1 1 CD cord-015306-us58wwmp 3612 13 chronic chronic JJ cord-015306-us58wwmp 3612 14 CNI CNI NNP cord-015306-us58wwmp 3612 15 nephrotoxicity nephrotoxicity NN cord-015306-us58wwmp 3612 16 , , , cord-015306-us58wwmp 3612 17 2 2 CD cord-015306-us58wwmp 3612 18 chronic chronic JJ cord-015306-us58wwmp 3612 19 allograft allograft NN cord-015306-us58wwmp 3612 20 nephropathy nephropathy NN cord-015306-us58wwmp 3612 21 ( ( -LRB- cord-015306-us58wwmp 3612 22 CAN CAN MD cord-015306-us58wwmp 3612 23 ) ) -RRB- cord-015306-us58wwmp 3612 24 and and CC cord-015306-us58wwmp 3612 25 2 2 CD cord-015306-us58wwmp 3612 26 unfavorable unfavorable JJ cord-015306-us58wwmp 3612 27 graft graft NN cord-015306-us58wwmp 3612 28 functions function NNS cord-015306-us58wwmp 3612 29 with with IN cord-015306-us58wwmp 3612 30 history history NN cord-015306-us58wwmp 3612 31 of of IN cord-015306-us58wwmp 3612 32 delay delay NN cord-015306-us58wwmp 3612 33 graft graft NN cord-015306-us58wwmp 3612 34 function function NN cord-015306-us58wwmp 3612 35 . . . cord-015306-us58wwmp 3613 1 Median median JJ cord-015306-us58wwmp 3613 2 duration duration NN cord-015306-us58wwmp 3613 3 from from IN cord-015306-us58wwmp 3613 4 transplantation transplantation NN cord-015306-us58wwmp 3613 5 to to IN cord-015306-us58wwmp 3613 6 CNI CNI NNP cord-015306-us58wwmp 3613 7 conversion conversion NN cord-015306-us58wwmp 3613 8 was be VBD cord-015306-us58wwmp 3613 9 4.5 4.5 CD cord-015306-us58wwmp 3613 10 months month NNS cord-015306-us58wwmp 3613 11 ( ( -LRB- cord-015306-us58wwmp 3613 12 range range VBP cord-015306-us58wwmp 3613 13 0.8 0.8 CD cord-015306-us58wwmp 3613 14 - - SYM cord-015306-us58wwmp 3613 15 88 88 CD cord-015306-us58wwmp 3613 16 ) ) -RRB- cord-015306-us58wwmp 3613 17 and and CC cord-015306-us58wwmp 3613 18 median median JJ cord-015306-us58wwmp 3613 19 time time NN cord-015306-us58wwmp 3613 20 from from IN cord-015306-us58wwmp 3613 21 conversion conversion NN cord-015306-us58wwmp 3613 22 to to IN cord-015306-us58wwmp 3613 23 the the DT cord-015306-us58wwmp 3613 24 last last JJ cord-015306-us58wwmp 3613 25 follow follow NN cord-015306-us58wwmp 3613 26 - - HYPH cord-015306-us58wwmp 3613 27 up up NN cord-015306-us58wwmp 3613 28 was be VBD cord-015306-us58wwmp 3613 29 8 8 CD cord-015306-us58wwmp 3613 30 months month NNS cord-015306-us58wwmp 3614 1 ( ( -LRB- cord-015306-us58wwmp 3614 2 range range NNP cord-015306-us58wwmp 3614 3 2 2 CD cord-015306-us58wwmp 3614 4 - - SYM cord-015306-us58wwmp 3614 5 26 26 CD cord-015306-us58wwmp 3614 6 ) ) -RRB- cord-015306-us58wwmp 3614 7 . . . cord-015306-us58wwmp 3615 1 Mean mean JJ cord-015306-us58wwmp 3615 2 creatinine creatinine NN cord-015306-us58wwmp 3615 3 clearance clearance NN cord-015306-us58wwmp 3615 4 ( ( -LRB- cord-015306-us58wwmp 3615 5 CrCl CrCl NNP cord-015306-us58wwmp 3615 6 ) ) -RRB- cord-015306-us58wwmp 3616 1 prior prior RB cord-015306-us58wwmp 3616 2 to to IN cord-015306-us58wwmp 3616 3 the the DT cord-015306-us58wwmp 3616 4 CNI CNI NNP cord-015306-us58wwmp 3616 5 elimination elimination NN cord-015306-us58wwmp 3616 6 was be VBD cord-015306-us58wwmp 3616 7 33.0±13.2 33.0±13.2 CD cord-015306-us58wwmp 3616 8 , , , cord-015306-us58wwmp 3616 9 as as IN cord-015306-us58wwmp 3616 10 compared compare VBN cord-015306-us58wwmp 3616 11 to to TO cord-015306-us58wwmp 3616 12 mean mean VB cord-015306-us58wwmp 3616 13 CrCl crcl NN cord-015306-us58wwmp 3616 14 of of IN cord-015306-us58wwmp 3616 15 49.0±16.3 49.0±16.3 CD cord-015306-us58wwmp 3616 16 ml/ ml/ XX cord-015306-us58wwmp 3617 1 min/1.73 min/1.73 NNP cord-015306-us58wwmp 3617 2 m m CD cord-015306-us58wwmp 3617 3 2 2 CD cord-015306-us58wwmp 3617 4 at at IN cord-015306-us58wwmp 3617 5 last last JJ cord-015306-us58wwmp 3617 6 follow follow NN cord-015306-us58wwmp 3617 7 up up RP cord-015306-us58wwmp 3617 8 ( ( -LRB- cord-015306-us58wwmp 3617 9 p p NN cord-015306-us58wwmp 3617 10 = = SYM cord-015306-us58wwmp 3617 11 0.069 0.069 CD cord-015306-us58wwmp 3617 12 ) ) -RRB- cord-015306-us58wwmp 3617 13 . . . cord-015306-us58wwmp 3618 1 Three three CD cord-015306-us58wwmp 3618 2 patients patient NNS cord-015306-us58wwmp 3618 3 had have VBD cord-015306-us58wwmp 3618 4 acute acute JJ cord-015306-us58wwmp 3618 5 rejection rejection NN cord-015306-us58wwmp 3618 6 ( ( -LRB- cord-015306-us58wwmp 3618 7 AR AR NNP cord-015306-us58wwmp 3618 8 ) ) -RRB- cord-015306-us58wwmp 3618 9 before before IN cord-015306-us58wwmp 3618 10 the the DT cord-015306-us58wwmp 3618 11 conversion conversion NN cord-015306-us58wwmp 3618 12 , , , cord-015306-us58wwmp 3618 13 but but CC cord-015306-us58wwmp 3618 14 only only RB cord-015306-us58wwmp 3618 15 1 1 CD cord-015306-us58wwmp 3618 16 patient patient NN cord-015306-us58wwmp 3618 17 had have VBD cord-015306-us58wwmp 3618 18 AR AR NNP cord-015306-us58wwmp 3618 19 post post NN cord-015306-us58wwmp 3618 20 CNI cni NN cord-015306-us58wwmp 3618 21 elimination elimination NN cord-015306-us58wwmp 3618 22 . . . cord-015306-us58wwmp 3619 1 There there EX cord-015306-us58wwmp 3619 2 were be VBD cord-015306-us58wwmp 3619 3 no no DT cord-015306-us58wwmp 3619 4 patients patient NNS cord-015306-us58wwmp 3619 5 with with IN cord-015306-us58wwmp 3619 6 graft graft NN cord-015306-us58wwmp 3619 7 loss loss NN cord-015306-us58wwmp 3619 8 or or CC cord-015306-us58wwmp 3619 9 CNI cni NN cord-015306-us58wwmp 3619 10 - - HYPH cord-015306-us58wwmp 3619 11 elimination elimination NN cord-015306-us58wwmp 3619 12 failure failure NN cord-015306-us58wwmp 3619 13 . . . cord-015306-us58wwmp 3620 1 Conclusion conclusion NN cord-015306-us58wwmp 3620 2 : : : cord-015306-us58wwmp 3620 3 Conversion conversion NN cord-015306-us58wwmp 3620 4 from from IN cord-015306-us58wwmp 3620 5 CNI CNI NNP cord-015306-us58wwmp 3620 6 to to IN cord-015306-us58wwmp 3620 7 everolimus everolimus NNP cord-015306-us58wwmp 3620 8 was be VBD cord-015306-us58wwmp 3620 9 safe safe JJ cord-015306-us58wwmp 3620 10 without without IN cord-015306-us58wwmp 3620 11 increasing increase VBG cord-015306-us58wwmp 3620 12 risk risk NN cord-015306-us58wwmp 3620 13 of of IN cord-015306-us58wwmp 3620 14 acute acute JJ cord-015306-us58wwmp 3620 15 rejection rejection NN cord-015306-us58wwmp 3620 16 in in IN cord-015306-us58wwmp 3620 17 pediatric pediatric JJ cord-015306-us58wwmp 3620 18 kidney kidney NN cord-015306-us58wwmp 3620 19 transplant transplant NN cord-015306-us58wwmp 3620 20 patients patient NNS cord-015306-us58wwmp 3620 21 who who WP cord-015306-us58wwmp 3620 22 experienced experience VBD cord-015306-us58wwmp 3620 23 early early JJ cord-015306-us58wwmp 3620 24 and and CC cord-015306-us58wwmp 3620 25 late late JJ cord-015306-us58wwmp 3620 26 CNI CNI NNP cord-015306-us58wwmp 3620 27 associated associate VBD cord-015306-us58wwmp 3620 28 complications complication NNS cord-015306-us58wwmp 3620 29 . . . cord-015306-us58wwmp 3621 1 Objective objective JJ cord-015306-us58wwmp 3621 2 : : : cord-015306-us58wwmp 3621 3 Due due IN cord-015306-us58wwmp 3621 4 to to IN cord-015306-us58wwmp 3621 5 a a DT cord-015306-us58wwmp 3621 6 severe severe JJ cord-015306-us58wwmp 3621 7 shortage shortage NN cord-015306-us58wwmp 3621 8 of of IN cord-015306-us58wwmp 3621 9 suitable suitable JJ cord-015306-us58wwmp 3621 10 deceased deceased JJ cord-015306-us58wwmp 3621 11 - - HYPH cord-015306-us58wwmp 3621 12 donor donor NN cord-015306-us58wwmp 3621 13 kidneys kidney NNS cord-015306-us58wwmp 3621 14 for for IN cord-015306-us58wwmp 3621 15 children child NNS cord-015306-us58wwmp 3621 16 awaiting await VBG cord-015306-us58wwmp 3621 17 kidney kidney NN cord-015306-us58wwmp 3621 18 transplants transplant NNS cord-015306-us58wwmp 3621 19 ( ( -LRB- cord-015306-us58wwmp 3621 20 KT KT NNP cord-015306-us58wwmp 3621 21 ) ) -RRB- cord-015306-us58wwmp 3621 22 , , , cord-015306-us58wwmp 3621 23 we -PRON- PRP cord-015306-us58wwmp 3621 24 have have VBP cord-015306-us58wwmp 3621 25 performed perform VBN cord-015306-us58wwmp 3621 26 a a DT cord-015306-us58wwmp 3621 27 series series NN cord-015306-us58wwmp 3621 28 of of IN cord-015306-us58wwmp 3621 29 ABO ABO NNP cord-015306-us58wwmp 3621 30 - - HYPH cord-015306-us58wwmp 3621 31 incompatible incompatible JJ cord-015306-us58wwmp 3622 1 ( ( -LRB- cord-015306-us58wwmp 3622 2 ABO ABO NNP cord-015306-us58wwmp 3622 3 - - HYPH cord-015306-us58wwmp 3622 4 i i NNP cord-015306-us58wwmp 3622 5 ) ) -RRB- cord-015306-us58wwmp 3622 6 living live VBG cord-015306-us58wwmp 3622 7 KT kt NN cord-015306-us58wwmp 3622 8 since since IN cord-015306-us58wwmp 3622 9 1989 1989 CD cord-015306-us58wwmp 3622 10 . . . cord-015306-us58wwmp 3623 1 Historically historically RB cord-015306-us58wwmp 3623 2 , , , cord-015306-us58wwmp 3623 3 ABO ABO NNP cord-015306-us58wwmp 3623 4 - - HYPH cord-015306-us58wwmp 3623 5 i i PRP cord-015306-us58wwmp 3623 6 KT KT NNP cord-015306-us58wwmp 3623 7 was be VBD cord-015306-us58wwmp 3623 8 performed perform VBN cord-015306-us58wwmp 3623 9 using use VBG cord-015306-us58wwmp 3623 10 several several JJ cord-015306-us58wwmp 3623 11 session session NN cord-015306-us58wwmp 3623 12 of of IN cord-015306-us58wwmp 3623 13 plasmapheresis plasmapheresis NN cord-015306-us58wwmp 3623 14 ( ( -LRB- cord-015306-us58wwmp 3623 15 PP PP NNP cord-015306-us58wwmp 3623 16 ) ) -RRB- cord-015306-us58wwmp 3623 17 to to TO cord-015306-us58wwmp 3623 18 remove remove VB cord-015306-us58wwmp 3623 19 existing exist VBG cord-015306-us58wwmp 3623 20 anti anti JJ cord-015306-us58wwmp 3623 21 - - JJ cord-015306-us58wwmp 3623 22 A a JJ cord-015306-us58wwmp 3623 23 or or CC cord-015306-us58wwmp 3623 24 anti anti JJ cord-015306-us58wwmp 3623 25 - - JJ cord-015306-us58wwmp 3623 26 B b JJ cord-015306-us58wwmp 3623 27 antibodies antibody NNS cord-015306-us58wwmp 3623 28 , , , cord-015306-us58wwmp 3623 29 followed follow VBN cord-015306-us58wwmp 3623 30 by by IN cord-015306-us58wwmp 3623 31 splenectomy splenectomy NN cord-015306-us58wwmp 3623 32 to to TO cord-015306-us58wwmp 3623 33 prevent prevent VB cord-015306-us58wwmp 3623 34 rebound rebound NN cord-015306-us58wwmp 3623 35 of of IN cord-015306-us58wwmp 3623 36 antibodies antibody NNS cord-015306-us58wwmp 3623 37 . . . cord-015306-us58wwmp 3624 1 Because because IN cord-015306-us58wwmp 3624 2 splenectomy splenectomy NN cord-015306-us58wwmp 3624 3 had have VBD cord-015306-us58wwmp 3624 4 risks risk NNS cord-015306-us58wwmp 3624 5 of of IN cord-015306-us58wwmp 3624 6 surgical surgical JJ cord-015306-us58wwmp 3624 7 complications complication NNS cord-015306-us58wwmp 3624 8 including include VBG cord-015306-us58wwmp 3624 9 bleeding bleed VBG cord-015306-us58wwmp 3624 10 and and CC cord-015306-us58wwmp 3624 11 pancreatic pancreatic NN cord-015306-us58wwmp 3624 12 pseudocyst pseudocyst NN cord-015306-us58wwmp 3624 13 , , , cord-015306-us58wwmp 3624 14 we -PRON- PRP cord-015306-us58wwmp 3624 15 introduced introduce VBD cord-015306-us58wwmp 3624 16 a a DT cord-015306-us58wwmp 3624 17 new new JJ cord-015306-us58wwmp 3624 18 protocol protocol NN cord-015306-us58wwmp 3624 19 , , , cord-015306-us58wwmp 3624 20 for for IN cord-015306-us58wwmp 3624 21 ABO ABO NNP cord-015306-us58wwmp 3624 22 - - HYPH cord-015306-us58wwmp 3624 23 i i NNP cord-015306-us58wwmp 3624 24 KT KT NNP cord-015306-us58wwmp 3624 25 , , , cord-015306-us58wwmp 3624 26 in in IN cord-015306-us58wwmp 3624 27 January January NNP cord-015306-us58wwmp 3624 28 2006 2006 CD cord-015306-us58wwmp 3624 29 . . . cord-015306-us58wwmp 3625 1 The the DT cord-015306-us58wwmp 3625 2 new new JJ cord-015306-us58wwmp 3625 3 protocol protocol NN cord-015306-us58wwmp 3625 4 without without IN cord-015306-us58wwmp 3625 5 splenectomy splenectomy NN cord-015306-us58wwmp 3625 6 utilizes utilize VBZ cord-015306-us58wwmp 3625 7 the the DT cord-015306-us58wwmp 3625 8 anti anti JJ cord-015306-us58wwmp 3625 9 - - JJ cord-015306-us58wwmp 3625 10 CD20 cd20 JJ cord-015306-us58wwmp 3625 11 monoclonal monoclonal JJ cord-015306-us58wwmp 3625 12 antibody antibody NN cord-015306-us58wwmp 3625 13 ( ( -LRB- cord-015306-us58wwmp 3625 14 rituximab rituximab NN cord-015306-us58wwmp 3625 15 ) ) -RRB- cord-015306-us58wwmp 3625 16 and and CC cord-015306-us58wwmp 3625 17 PP PP NNP cord-015306-us58wwmp 3625 18 . . . cord-015306-us58wwmp 3626 1 This this DT cord-015306-us58wwmp 3626 2 study study NN cord-015306-us58wwmp 3626 3 retrospectivery retrospectivery NN cord-015306-us58wwmp 3626 4 examined examine VBD cord-015306-us58wwmp 3626 5 the the DT cord-015306-us58wwmp 3626 6 efficacy efficacy NN cord-015306-us58wwmp 3626 7 and and CC cord-015306-us58wwmp 3626 8 safety safety NN cord-015306-us58wwmp 3626 9 of of IN cord-015306-us58wwmp 3626 10 this this DT cord-015306-us58wwmp 3626 11 protocol protocol NN cord-015306-us58wwmp 3626 12 . . . cord-015306-us58wwmp 3627 1 Methods method NNS cord-015306-us58wwmp 3627 2 : : : cord-015306-us58wwmp 3628 1 Eight eight CD cord-015306-us58wwmp 3629 1 de de NNP cord-015306-us58wwmp 3629 2 novo novo NNP cord-015306-us58wwmp 3629 3 ABO ABO NNP cord-015306-us58wwmp 3630 1 -i -i NFP cord-015306-us58wwmp 3630 2 KT KT NNP cord-015306-us58wwmp 3630 3 ( ( -LRB- cord-015306-us58wwmp 3630 4 5 5 CD cord-015306-us58wwmp 3630 5 males male NNS cord-015306-us58wwmp 3630 6 and and CC cord-015306-us58wwmp 3630 7 3 3 CD cord-015306-us58wwmp 3630 8 females female NNS cord-015306-us58wwmp 3630 9 ) ) -RRB- cord-015306-us58wwmp 3630 10 were be VBD cord-015306-us58wwmp 3630 11 performed perform VBN cord-015306-us58wwmp 3630 12 between between IN cord-015306-us58wwmp 3630 13 January January NNP cord-015306-us58wwmp 3630 14 2006 2006 CD cord-015306-us58wwmp 3630 15 and and CC cord-015306-us58wwmp 3630 16 December December NNP cord-015306-us58wwmp 3630 17 2012 2012 CD cord-015306-us58wwmp 3630 18 . . . cord-015306-us58wwmp 3631 1 The the DT cord-015306-us58wwmp 3631 2 mean mean JJ cord-015306-us58wwmp 3631 3 age age NN cord-015306-us58wwmp 3631 4 at at IN cord-015306-us58wwmp 3631 5 transplantation transplantation NN cord-015306-us58wwmp 3631 6 was be VBD cord-015306-us58wwmp 3631 7 15.3±4.0 15.3±4.0 CD cord-015306-us58wwmp 3631 8 years year NNS cord-015306-us58wwmp 3632 1 ( ( -LRB- cord-015306-us58wwmp 3632 2 range range VB cord-015306-us58wwmp 3632 3 9.9 9.9 CD cord-015306-us58wwmp 3632 4 - - HYPH cord-015306-us58wwmp 3632 5 20.5 20.5 CD cord-015306-us58wwmp 3632 6 years year NNS cord-015306-us58wwmp 3632 7 ) ) -RRB- cord-015306-us58wwmp 3632 8 . . . cord-015306-us58wwmp 3633 1 The the DT cord-015306-us58wwmp 3633 2 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 3633 3 protocol protocol NN cord-015306-us58wwmp 3633 4 consisted consist VBD cord-015306-us58wwmp 3633 5 of of IN cord-015306-us58wwmp 3633 6 cyclospolin cyclospolin NNP cord-015306-us58wwmp 3633 7 or or CC cord-015306-us58wwmp 3633 8 tacrolimus tacrolimus NNP cord-015306-us58wwmp 3633 9 , , , cord-015306-us58wwmp 3633 10 mycophenolate mycophenolate NNP cord-015306-us58wwmp 3633 11 mofetil mofetil NNP cord-015306-us58wwmp 3633 12 , , , cord-015306-us58wwmp 3633 13 and and CC cord-015306-us58wwmp 3633 14 methylprednisolone methylprednisolone NN cord-015306-us58wwmp 3633 15 . . . cord-015306-us58wwmp 3634 1 All all DT cord-015306-us58wwmp 3634 2 patients patient NNS cord-015306-us58wwmp 3634 3 received receive VBD cord-015306-us58wwmp 3634 4 induction induction NN cord-015306-us58wwmp 3634 5 therapy therapy NN cord-015306-us58wwmp 3634 6 with with IN cord-015306-us58wwmp 3634 7 basiliximab basiliximab NNP cord-015306-us58wwmp 3634 8 . . . cord-015306-us58wwmp 3635 1 The the DT cord-015306-us58wwmp 3635 2 preconditioning preconditioning NN cord-015306-us58wwmp 3635 3 protocol protocol NN cord-015306-us58wwmp 3635 4 included include VBD cord-015306-us58wwmp 3635 5 PP PP NNP cord-015306-us58wwmp 3635 6 or or CC cord-015306-us58wwmp 3635 7 double double JJ cord-015306-us58wwmp 3635 8 filtration filtration NN cord-015306-us58wwmp 3635 9 plasmapheresis plasmapheresis NN cord-015306-us58wwmp 3635 10 ( ( -LRB- cord-015306-us58wwmp 3635 11 DFPP DFPP NNP cord-015306-us58wwmp 3635 12 ) ) -RRB- cord-015306-us58wwmp 3635 13 and and CC cord-015306-us58wwmp 3635 14 a a DT cord-015306-us58wwmp 3635 15 single single JJ cord-015306-us58wwmp 3635 16 dose dose NN cord-015306-us58wwmp 3635 17 of of IN cord-015306-us58wwmp 3635 18 rituximab rituximab JJ cord-015306-us58wwmp 3635 19 ( ( -LRB- cord-015306-us58wwmp 3635 20 average average JJ cord-015306-us58wwmp 3635 21 dosage dosage NN cord-015306-us58wwmp 3635 22 179 179 CD cord-015306-us58wwmp 3635 23 mg mg NNP cord-015306-us58wwmp 3635 24 / / SYM cord-015306-us58wwmp 3635 25 m m NNP cord-015306-us58wwmp 3635 26 2 2 CD cord-015306-us58wwmp 3635 27 ) ) -RRB- cord-015306-us58wwmp 3635 28 . . . cord-015306-us58wwmp 3636 1 All all DT cord-015306-us58wwmp 3636 2 patients patient NNS cord-015306-us58wwmp 3636 3 who who WP cord-015306-us58wwmp 3636 4 underwent undergo VBD cord-015306-us58wwmp 3636 5 KT KT NNP cord-015306-us58wwmp 3636 6 achieved achieve VBD cord-015306-us58wwmp 3636 7 a a DT cord-015306-us58wwmp 3636 8 isoagglutinin isoagglutinin NNS cord-015306-us58wwmp 3636 9 titer titer NN cord-015306-us58wwmp 3636 10 less less JJR cord-015306-us58wwmp 3636 11 than than IN cord-015306-us58wwmp 3636 12 1:16 1:16 CD cord-015306-us58wwmp 3636 13 with with IN cord-015306-us58wwmp 3636 14 1 1 CD cord-015306-us58wwmp 3636 15 - - SYM cord-015306-us58wwmp 3636 16 4 4 CD cord-015306-us58wwmp 3636 17 sessions session NNS cord-015306-us58wwmp 3636 18 of of IN cord-015306-us58wwmp 3636 19 PP PP NNP cord-015306-us58wwmp 3636 20 / / SYM cord-015306-us58wwmp 3636 21 DFPP DFPP NNP cord-015306-us58wwmp 3636 22 treatment treatment NN cord-015306-us58wwmp 3636 23 before before IN cord-015306-us58wwmp 3636 24 transplant transplant NN cord-015306-us58wwmp 3636 25 . . . cord-015306-us58wwmp 3637 1 Results result NNS cord-015306-us58wwmp 3637 2 : : : cord-015306-us58wwmp 3638 1 The the DT cord-015306-us58wwmp 3638 2 patients patient NNS cord-015306-us58wwmp 3638 3 were be VBD cord-015306-us58wwmp 3638 4 followed follow VBN cord-015306-us58wwmp 3638 5 for for IN cord-015306-us58wwmp 3638 6 5 5 CD cord-015306-us58wwmp 3638 7 to to TO cord-015306-us58wwmp 3638 8 82 82 CD cord-015306-us58wwmp 3638 9 months month NNS cord-015306-us58wwmp 3638 10 with with IN cord-015306-us58wwmp 3638 11 a a DT cord-015306-us58wwmp 3638 12 mean mean JJ cord-015306-us58wwmp 3638 13 follow follow NN cord-015306-us58wwmp 3638 14 - - HYPH cord-015306-us58wwmp 3638 15 up up NN cord-015306-us58wwmp 3638 16 of of IN cord-015306-us58wwmp 3638 17 36 36 CD cord-015306-us58wwmp 3638 18 months month NNS cord-015306-us58wwmp 3638 19 . . . cord-015306-us58wwmp 3639 1 Patient patient JJ cord-015306-us58wwmp 3639 2 and and CC cord-015306-us58wwmp 3639 3 graft graft NN cord-015306-us58wwmp 3639 4 survival survival NN cord-015306-us58wwmp 3639 5 rates rate NNS cord-015306-us58wwmp 3639 6 were be VBD cord-015306-us58wwmp 3639 7 100 100 CD cord-015306-us58wwmp 3639 8 % % NN cord-015306-us58wwmp 3639 9 . . . cord-015306-us58wwmp 3640 1 One one CD cord-015306-us58wwmp 3640 2 non non JJ cord-015306-us58wwmp 3640 3 - - JJ cord-015306-us58wwmp 3640 4 adherent adherent JJ cord-015306-us58wwmp 3640 5 patient patient NN cord-015306-us58wwmp 3640 6 experienced experience VBD cord-015306-us58wwmp 3640 7 antibody antibody NN cord-015306-us58wwmp 3640 8 mediated mediate VBD cord-015306-us58wwmp 3640 9 rejection rejection NN cord-015306-us58wwmp 3640 10 . . . cord-015306-us58wwmp 3641 1 Figure1 Figure1 NNP cord-015306-us58wwmp 3641 2 ) ) -RRB- cord-015306-us58wwmp 3641 3 . . . cord-015306-us58wwmp 3642 1 In in IN cord-015306-us58wwmp 3642 2 the the DT cord-015306-us58wwmp 3642 3 RTR RTR NNP cord-015306-us58wwmp 3642 4 who who WP cord-015306-us58wwmp 3642 5 had have VBD cord-015306-us58wwmp 3642 6 graft graft NN cord-015306-us58wwmp 3642 7 loss loss NN cord-015306-us58wwmp 3642 8 , , , cord-015306-us58wwmp 3642 9 there there EX cord-015306-us58wwmp 3642 10 was be VBD cord-015306-us58wwmp 3642 11 no no DT cord-015306-us58wwmp 3642 12 significant significant JJ cord-015306-us58wwmp 3642 13 difference difference NN cord-015306-us58wwmp 3642 14 in in IN cord-015306-us58wwmp 3642 15 graft graft NN cord-015306-us58wwmp 3642 16 survival survival NN cord-015306-us58wwmp 3642 17 time time NN cord-015306-us58wwmp 3642 18 ( ( -LRB- cord-015306-us58wwmp 3642 19 6.0 6.0 CD cord-015306-us58wwmp 3642 20 , , , cord-015306-us58wwmp 3642 21 3.1 3.1 CD cord-015306-us58wwmp 3642 22 years year NNS cord-015306-us58wwmp 3642 23 , , , cord-015306-us58wwmp 3642 24 DSA DSA NNP cord-015306-us58wwmp 3642 25 negative negative NN cord-015306-us58wwmp 3642 26 vs vs IN cord-015306-us58wwmp 3642 27 DSA DSA NNP cord-015306-us58wwmp 3642 28 positive positive JJ cord-015306-us58wwmp 3642 29 ) ) -RRB- cord-015306-us58wwmp 3642 30 , , , cord-015306-us58wwmp 3642 31 Grade grade NN cord-015306-us58wwmp 3642 32 1 1 CD cord-015306-us58wwmp 3642 33 rejection rejection NN cord-015306-us58wwmp 3642 34 ( ( -LRB- cord-015306-us58wwmp 3642 35 0.5 0.5 CD cord-015306-us58wwmp 3642 36 , , , cord-015306-us58wwmp 3642 37 0.7 0.7 CD cord-015306-us58wwmp 3642 38 episodes episode NNS cord-015306-us58wwmp 3642 39 per per IN cord-015306-us58wwmp 3642 40 patient patient NN cord-015306-us58wwmp 3642 41 ) ) -RRB- cord-015306-us58wwmp 3642 42 , , , cord-015306-us58wwmp 3642 43 Grade grade NN cord-015306-us58wwmp 3642 44 2 2 CD cord-015306-us58wwmp 3642 45 rejection rejection NN cord-015306-us58wwmp 3642 46 ( ( -LRB- cord-015306-us58wwmp 3642 47 0.5 0.5 CD cord-015306-us58wwmp 3642 48 , , , cord-015306-us58wwmp 3642 49 0.7 0.7 CD cord-015306-us58wwmp 3642 50 episodes episode NNS cord-015306-us58wwmp 3642 51 per per IN cord-015306-us58wwmp 3642 52 patient patient NN cord-015306-us58wwmp 3642 53 ) ) -RRB- cord-015306-us58wwmp 3642 54 or or CC cord-015306-us58wwmp 3642 55 C4d C4d NNP cord-015306-us58wwmp 3642 56 staining stain VBG cord-015306-us58wwmp 3642 57 ( ( -LRB- cord-015306-us58wwmp 3642 58 100 100 CD cord-015306-us58wwmp 3642 59 % % NN cord-015306-us58wwmp 3642 60 , , , cord-015306-us58wwmp 3642 61 57 57 CD cord-015306-us58wwmp 3642 62 % % NN cord-015306-us58wwmp 3642 63 patients patient NNS cord-015306-us58wwmp 3642 64 ) ) -RRB- cord-015306-us58wwmp 3642 65 . . . cord-015306-us58wwmp 3643 1 One one CD cord-015306-us58wwmp 3643 2 patient patient NN cord-015306-us58wwmp 3643 3 in in IN cord-015306-us58wwmp 3643 4 each each DT cord-015306-us58wwmp 3643 5 group group NN cord-015306-us58wwmp 3643 6 had have VBD cord-015306-us58wwmp 3643 7 BK BK NNP cord-015306-us58wwmp 3643 8 virus virus NN cord-015306-us58wwmp 3643 9 associated associate VBD cord-015306-us58wwmp 3643 10 nephropathy nephropathy NN cord-015306-us58wwmp 3643 11 . . . cord-015306-us58wwmp 3644 1 Two two CD cord-015306-us58wwmp 3644 2 patients patient NNS cord-015306-us58wwmp 3644 3 had have VBD cord-015306-us58wwmp 3644 4 plasma plasma NN cord-015306-us58wwmp 3644 5 cell cell NN cord-015306-us58wwmp 3644 6 infiltrates infiltrate VBZ cord-015306-us58wwmp 3644 7 on on IN cord-015306-us58wwmp 3644 8 biopsy biopsy NN cord-015306-us58wwmp 3644 9 and and CC cord-015306-us58wwmp 3644 10 lost lose VBD cord-015306-us58wwmp 3644 11 their -PRON- PRP$ cord-015306-us58wwmp 3644 12 grafts graft NNS cord-015306-us58wwmp 3644 13 within within IN cord-015306-us58wwmp 3644 14 6 6 CD cord-015306-us58wwmp 3644 15 months month NNS cord-015306-us58wwmp 3644 16 of of IN cord-015306-us58wwmp 3644 17 DSA DSA NNP cord-015306-us58wwmp 3644 18 detection detection NN cord-015306-us58wwmp 3644 19 . . . cord-015306-us58wwmp 3645 1 Results result NNS cord-015306-us58wwmp 3645 2 : : : cord-015306-us58wwmp 3646 1 Fifty fifty CD cord-015306-us58wwmp 3646 2 - - HYPH cord-015306-us58wwmp 3646 3 one one CD cord-015306-us58wwmp 3646 4 kidney kidney NN cord-015306-us58wwmp 3646 5 recipients recipient NNS cord-015306-us58wwmp 3646 6 ( ( -LRB- cord-015306-us58wwmp 3646 7 male male JJ cord-015306-us58wwmp 3646 8 32 32 CD cord-015306-us58wwmp 3646 9 cases case NNS cord-015306-us58wwmp 3646 10 ; ; : cord-015306-us58wwmp 3646 11 female female JJ cord-015306-us58wwmp 3646 12 19cases 19case NNS cord-015306-us58wwmp 3646 13 ) ) -RRB- cord-015306-us58wwmp 3646 14 were be VBD cord-015306-us58wwmp 3646 15 enrolled enrol VBN cord-015306-us58wwmp 3646 16 in in IN cord-015306-us58wwmp 3646 17 this this DT cord-015306-us58wwmp 3646 18 study study NN cord-015306-us58wwmp 3646 19 . . . cord-015306-us58wwmp 3647 1 The the DT cord-015306-us58wwmp 3647 2 median median JJ cord-015306-us58wwmp 3647 3 age age NN cord-015306-us58wwmp 3647 4 was be VBD cord-015306-us58wwmp 3647 5 15 15 CD cord-015306-us58wwmp 3647 6 years year NNS cord-015306-us58wwmp 3647 7 , , , cord-015306-us58wwmp 3647 8 the the DT cord-015306-us58wwmp 3647 9 youngest young JJS cord-015306-us58wwmp 3647 10 kidney kidney NN cord-015306-us58wwmp 3647 11 recipient recipient NN cord-015306-us58wwmp 3647 12 was be VBD cord-015306-us58wwmp 3647 13 3years 3year VBN cord-015306-us58wwmp 3647 14 old old JJ cord-015306-us58wwmp 3647 15 with with IN cord-015306-us58wwmp 3647 16 a a DT cord-015306-us58wwmp 3647 17 body body NN cord-015306-us58wwmp 3647 18 weight weight NN cord-015306-us58wwmp 3647 19 of of IN cord-015306-us58wwmp 3647 20 10.0 10.0 CD cord-015306-us58wwmp 3647 21 kg kg NNS cord-015306-us58wwmp 3647 22 ) ) -RRB- cord-015306-us58wwmp 3647 23 . . . cord-015306-us58wwmp 3648 1 There there EX cord-015306-us58wwmp 3648 2 were be VBD cord-015306-us58wwmp 3648 3 11 11 CD cord-015306-us58wwmp 3648 4 recipients recipient NNS cord-015306-us58wwmp 3648 5 less less JJR cord-015306-us58wwmp 3648 6 than than IN cord-015306-us58wwmp 3648 7 equal equal JJ cord-015306-us58wwmp 3648 8 10 10 CD cord-015306-us58wwmp 3648 9 years year NNS cord-015306-us58wwmp 3648 10 , , , cord-015306-us58wwmp 3648 11 including include VBG cord-015306-us58wwmp 3648 12 one one CD cord-015306-us58wwmp 3648 13 children child NNS cord-015306-us58wwmp 3648 14 with with IN cord-015306-us58wwmp 3648 15 congenital congenital JJ cord-015306-us58wwmp 3648 16 renal renal JJ cord-015306-us58wwmp 3648 17 dysplasia dysplasia NN cord-015306-us58wwmp 3648 18 and and CC cord-015306-us58wwmp 3648 19 one one CD cord-015306-us58wwmp 3648 20 with with IN cord-015306-us58wwmp 3648 21 congenital congenital JJ cord-015306-us58wwmp 3648 22 renal renal JJ cord-015306-us58wwmp 3648 23 artery artery NN cord-015306-us58wwmp 3648 24 malformation malformation NN cord-015306-us58wwmp 3648 25 . . . cord-015306-us58wwmp 3649 1 About about RB cord-015306-us58wwmp 3649 2 73.7 73.7 CD cord-015306-us58wwmp 3649 3 % % NN cord-015306-us58wwmp 3649 4 kidney kidney NN cord-015306-us58wwmp 3649 5 recipients recipient NNS cord-015306-us58wwmp 3649 6 came come VBD cord-015306-us58wwmp 3649 7 from from IN cord-015306-us58wwmp 3649 8 GuangdongProvince GuangdongProvince NNP cord-015306-us58wwmp 3649 9 . . . cord-015306-us58wwmp 3650 1 About about RB cord-015306-us58wwmp 3650 2 1 1 CD cord-015306-us58wwmp 3650 3 to to TO cord-015306-us58wwmp 3650 4 7 7 CD cord-015306-us58wwmp 3650 5 pediatric pediatric JJ cord-015306-us58wwmp 3650 6 patients patient NNS cord-015306-us58wwmp 3650 7 accepted accept VBD cord-015306-us58wwmp 3650 8 renal renal JJ cord-015306-us58wwmp 3650 9 transplatation transplatation NN cord-015306-us58wwmp 3650 10 each each DT cord-015306-us58wwmp 3650 11 year year NN cord-015306-us58wwmp 3650 12 from from IN cord-015306-us58wwmp 3650 13 2003 2003 CD cord-015306-us58wwmp 3650 14 to to IN cord-015306-us58wwmp 3650 15 2011 2011 CD cord-015306-us58wwmp 3650 16 , , , cord-015306-us58wwmp 3650 17 but but CC cord-015306-us58wwmp 3650 18 there there EX cord-015306-us58wwmp 3650 19 were13 were13 NNP cord-015306-us58wwmp 3650 20 in2012 in2012 NNP cord-015306-us58wwmp 3650 21 , , , cord-015306-us58wwmp 3650 22 which which WDT cord-015306-us58wwmp 3650 23 showed show VBD cord-015306-us58wwmp 3650 24 a a DT cord-015306-us58wwmp 3650 25 significant significant JJ cord-015306-us58wwmp 3650 26 increase increase NN cord-015306-us58wwmp 3650 27 than than IN cord-015306-us58wwmp 3650 28 in in IN cord-015306-us58wwmp 3650 29 each each DT cord-015306-us58wwmp 3650 30 previous previous JJ cord-015306-us58wwmp 3650 31 sigle sigle JJ cord-015306-us58wwmp 3650 32 year year NN cord-015306-us58wwmp 3650 33 . . . cord-015306-us58wwmp 3651 1 The the DT cord-015306-us58wwmp 3651 2 policy policy NN cord-015306-us58wwmp 3651 3 that that WDT cord-015306-us58wwmp 3651 4 children child NNS cord-015306-us58wwmp 3651 5 had have VBD cord-015306-us58wwmp 3651 6 a a DT cord-015306-us58wwmp 3651 7 kidney kidney NN cord-015306-us58wwmp 3651 8 recipients recipient NNS cord-015306-us58wwmp 3651 9 priority priority NN cord-015306-us58wwmp 3651 10 may may MD cord-015306-us58wwmp 3651 11 contribute contribute VB cord-015306-us58wwmp 3651 12 to to IN cord-015306-us58wwmp 3651 13 this this DT cord-015306-us58wwmp 3651 14 increase increase NN cord-015306-us58wwmp 3651 15 . . . cord-015306-us58wwmp 3652 1 The the DT cord-015306-us58wwmp 3652 2 kidney kidney NN cord-015306-us58wwmp 3652 3 donors donor NNS cord-015306-us58wwmp 3652 4 were be VBD cord-015306-us58wwmp 3652 5 cadaveric cadaveric JJ cord-015306-us58wwmp 3652 6 kidneys(72.5 kidneys(72.5 NNP cord-015306-us58wwmp 3652 7 % % NN cord-015306-us58wwmp 3652 8 ) ) -RRB- cord-015306-us58wwmp 3652 9 and and CC cord-015306-us58wwmp 3652 10 living live VBG cord-015306-us58wwmp 3652 11 kidneys(27.4 kidneys(27.4 NNP cord-015306-us58wwmp 3652 12 % % NN cord-015306-us58wwmp 3652 13 ) ) -RRB- cord-015306-us58wwmp 3652 14 , , , cord-015306-us58wwmp 3652 15 only only RB cord-015306-us58wwmp 3652 16 one one CD cord-015306-us58wwmp 3652 17 patient patient NN cord-015306-us58wwmp 3652 18 accepted accept VBN cord-015306-us58wwmp 3652 19 auto auto NN cord-015306-us58wwmp 3652 20 - - HYPH cord-015306-us58wwmp 3652 21 renal renal JJ cord-015306-us58wwmp 3652 22 - - HYPH cord-015306-us58wwmp 3652 23 transplatation transplatation NN cord-015306-us58wwmp 3652 24 . . . cord-015306-us58wwmp 3653 1 All all DT cord-015306-us58wwmp 3653 2 kidney kidney NN cord-015306-us58wwmp 3653 3 recipients recipient NNS cord-015306-us58wwmp 3653 4 were be VBD cord-015306-us58wwmp 3653 5 survival survival NN cord-015306-us58wwmp 3653 6 to to TO cord-015306-us58wwmp 3653 7 present present VB cord-015306-us58wwmp 3653 8 with with IN cord-015306-us58wwmp 3653 9 the the DT cord-015306-us58wwmp 3653 10 treatment treatment NN cord-015306-us58wwmp 3653 11 of of IN cord-015306-us58wwmp 3653 12 glucocorticoid glucocorticoid NN cord-015306-us58wwmp 3653 13 and and CC cord-015306-us58wwmp 3653 14 or or CC cord-015306-us58wwmp 3653 15 immunosuppressants immunosuppressant NNS cord-015306-us58wwmp 3653 16 , , , cord-015306-us58wwmp 3653 17 such such JJ cord-015306-us58wwmp 3653 18 as as IN cord-015306-us58wwmp 3653 19 CsA csa NN cord-015306-us58wwmp 3653 20 , , , cord-015306-us58wwmp 3653 21 FK506 FK506 NNP cord-015306-us58wwmp 3653 22 , , , cord-015306-us58wwmp 3653 23 MMF mmf NN cord-015306-us58wwmp 3653 24 , , , cord-015306-us58wwmp 3653 25 ect ect FW cord-015306-us58wwmp 3653 26 . . . cord-015306-us58wwmp 3654 1 Only only RB cord-015306-us58wwmp 3654 2 two two CD cord-015306-us58wwmp 3654 3 patients patient NNS cord-015306-us58wwmp 3654 4 accepted accept VBD cord-015306-us58wwmp 3654 5 retransplatation retransplatation NN cord-015306-us58wwmp 3654 6 due due IN cord-015306-us58wwmp 3654 7 to to IN cord-015306-us58wwmp 3654 8 losing lose VBG cord-015306-us58wwmp 3654 9 function function NN cord-015306-us58wwmp 3654 10 of of IN cord-015306-us58wwmp 3654 11 the the DT cord-015306-us58wwmp 3654 12 renal renal JJ cord-015306-us58wwmp 3654 13 grafts graft NNS cord-015306-us58wwmp 3654 14 . . . cord-015306-us58wwmp 3655 1 Conclusion conclusion NN cord-015306-us58wwmp 3655 2 : : : cord-015306-us58wwmp 3655 3 Renal renal JJ cord-015306-us58wwmp 3655 4 transplantation transplantation NN cord-015306-us58wwmp 3655 5 in in IN cord-015306-us58wwmp 3655 6 children child NNS cord-015306-us58wwmp 3655 7 increased increase VBD cord-015306-us58wwmp 3655 8 significantly significantly RB cord-015306-us58wwmp 3655 9 in in IN cord-015306-us58wwmp 3655 10 2012 2012 CD cord-015306-us58wwmp 3655 11 in in IN cord-015306-us58wwmp 3655 12 our -PRON- PRP$ cord-015306-us58wwmp 3655 13 hospital hospital NN cord-015306-us58wwmp 3655 14 , , , cord-015306-us58wwmp 3655 15 and and CC cord-015306-us58wwmp 3655 16 it -PRON- PRP cord-015306-us58wwmp 3655 17 seemed seem VBD cord-015306-us58wwmp 3655 18 an an DT cord-015306-us58wwmp 3655 19 effective effective JJ cord-015306-us58wwmp 3655 20 treatment treatment NN cord-015306-us58wwmp 3655 21 to to IN cord-015306-us58wwmp 3655 22 children child NNS cord-015306-us58wwmp 3655 23 with with IN cord-015306-us58wwmp 3655 24 ESRD ESRD NNP cord-015306-us58wwmp 3655 25 . . . cord-015306-us58wwmp 3656 1 Recent recent JJ cord-015306-us58wwmp 3656 2 adult adult NN cord-015306-us58wwmp 3656 3 studies study NNS cord-015306-us58wwmp 3656 4 have have VBP cord-015306-us58wwmp 3656 5 shown show VBN cord-015306-us58wwmp 3656 6 that that IN cord-015306-us58wwmp 3656 7 low low JJ cord-015306-us58wwmp 3656 8 levels level NNS cord-015306-us58wwmp 3656 9 of of IN cord-015306-us58wwmp 3656 10 immunosuppression immunosuppression NN cord-015306-us58wwmp 3656 11 ( ( -LRB- cord-015306-us58wwmp 3656 12 IS is NN cord-015306-us58wwmp 3656 13 ) ) -RRB- cord-015306-us58wwmp 3656 14 are be VBP cord-015306-us58wwmp 3656 15 associated associate VBN cord-015306-us58wwmp 3656 16 with with IN cord-015306-us58wwmp 3656 17 dnDSA dndsa NN cord-015306-us58wwmp 3656 18 . . . cord-015306-us58wwmp 3657 1 However however RB cord-015306-us58wwmp 3657 2 , , , cord-015306-us58wwmp 3657 3 limited limited JJ cord-015306-us58wwmp 3657 4 data data NN cord-015306-us58wwmp 3657 5 is be VBZ cord-015306-us58wwmp 3657 6 available available JJ cord-015306-us58wwmp 3657 7 on on IN cord-015306-us58wwmp 3657 8 significance significance NN cord-015306-us58wwmp 3657 9 of of IN cord-015306-us58wwmp 3657 10 dnDSA dndsa NN cord-015306-us58wwmp 3657 11 and and CC cord-015306-us58wwmp 3657 12 its -PRON- PRP$ cord-015306-us58wwmp 3657 13 management management NN cord-015306-us58wwmp 3657 14 in in IN cord-015306-us58wwmp 3657 15 paediatric paediatric JJ cord-015306-us58wwmp 3657 16 population population NN cord-015306-us58wwmp 3657 17 . . . cord-015306-us58wwmp 3658 1 To to TO cord-015306-us58wwmp 3658 2 assess assess VB cord-015306-us58wwmp 3658 3 relationship relationship NN cord-015306-us58wwmp 3658 4 between between IN cord-015306-us58wwmp 3658 5 dnDSA dndsa NN cord-015306-us58wwmp 3658 6 with with IN cord-015306-us58wwmp 3658 7 renal renal JJ cord-015306-us58wwmp 3658 8 function function NN cord-015306-us58wwmp 3658 9 , , , cord-015306-us58wwmp 3658 10 histological histological JJ cord-015306-us58wwmp 3658 11 findings finding NNS cord-015306-us58wwmp 3658 12 , , , cord-015306-us58wwmp 3658 13 immunosuppression immunosuppression NN cord-015306-us58wwmp 3658 14 levels level NNS cord-015306-us58wwmp 3658 15 and and CC cord-015306-us58wwmp 3658 16 graft graft NN cord-015306-us58wwmp 3658 17 outcome outcome NN cord-015306-us58wwmp 3658 18 in in IN cord-015306-us58wwmp 3658 19 paediatric paediatric JJ cord-015306-us58wwmp 3658 20 renal renal JJ cord-015306-us58wwmp 3658 21 transplant transplant NN cord-015306-us58wwmp 3658 22 recipients recipient NNS cord-015306-us58wwmp 3658 23 ( ( -LRB- cord-015306-us58wwmp 3658 24 RTR RTR NNP cord-015306-us58wwmp 3658 25 ) ) -RRB- cord-015306-us58wwmp 3658 26 . . . cord-015306-us58wwmp 3659 1 In in IN cord-015306-us58wwmp 3659 2 our -PRON- PRP$ cord-015306-us58wwmp 3659 3 centre centre NN cord-015306-us58wwmp 3659 4 , , , cord-015306-us58wwmp 3659 5 at at IN cord-015306-us58wwmp 3659 6 the the DT cord-015306-us58wwmp 3659 7 time time NN cord-015306-us58wwmp 3659 8 of of IN cord-015306-us58wwmp 3659 9 the the DT cord-015306-us58wwmp 3659 10 study study NN cord-015306-us58wwmp 3659 11 , , , cord-015306-us58wwmp 3659 12 DSA DSA NNP cord-015306-us58wwmp 3659 13 were be VBD cord-015306-us58wwmp 3659 14 tested test VBN cord-015306-us58wwmp 3659 15 if if IN cord-015306-us58wwmp 3659 16 deterioration deterioration NN cord-015306-us58wwmp 3659 17 in in IN cord-015306-us58wwmp 3659 18 graft graft NN cord-015306-us58wwmp 3659 19 function function NN cord-015306-us58wwmp 3659 20 was be VBD cord-015306-us58wwmp 3659 21 found find VBN cord-015306-us58wwmp 3659 22 necessitating necessitate VBG cord-015306-us58wwmp 3659 23 renal renal JJ cord-015306-us58wwmp 3659 24 biopsy biopsy NN cord-015306-us58wwmp 3659 25 . . . cord-015306-us58wwmp 3660 1 Methods method NNS cord-015306-us58wwmp 3660 2 : : : cord-015306-us58wwmp 3661 1 Retrospective retrospective JJ cord-015306-us58wwmp 3661 2 review review NN cord-015306-us58wwmp 3661 3 of of IN cord-015306-us58wwmp 3661 4 all all DT cord-015306-us58wwmp 3661 5 RTRs rtr NNS cord-015306-us58wwmp 3661 6 in in IN cord-015306-us58wwmp 3661 7 a a DT cord-015306-us58wwmp 3661 8 single single JJ cord-015306-us58wwmp 3661 9 tertiary tertiary JJ cord-015306-us58wwmp 3661 10 nephrology nephrology NN cord-015306-us58wwmp 3661 11 centre centre NN cord-015306-us58wwmp 3661 12 tested test VBN cord-015306-us58wwmp 3661 13 for for IN cord-015306-us58wwmp 3661 14 dnDSA dndsa NN cord-015306-us58wwmp 3661 15 . . . cord-015306-us58wwmp 3662 1 Data datum NNS cord-015306-us58wwmp 3662 2 collected collect VBN cord-015306-us58wwmp 3662 3 included include VBN cord-015306-us58wwmp 3662 4 dnDSA dndsa NN cord-015306-us58wwmp 3662 5 , , , cord-015306-us58wwmp 3662 6 histological histological JJ cord-015306-us58wwmp 3662 7 findings finding NNS cord-015306-us58wwmp 3662 8 , , , cord-015306-us58wwmp 3662 9 eGFR eGFR VBN cord-015306-us58wwmp 3662 10 as as IN cord-015306-us58wwmp 3662 11 marker marker NN cord-015306-us58wwmp 3662 12 of of IN cord-015306-us58wwmp 3662 13 renal renal JJ cord-015306-us58wwmp 3662 14 function function NN cord-015306-us58wwmp 3662 15 , , , cord-015306-us58wwmp 3662 16 baseline baseline JJ cord-015306-us58wwmp 3662 17 immunosuppression immunosuppression NN cord-015306-us58wwmp 3662 18 , , , cord-015306-us58wwmp 3662 19 subsequent subsequent JJ cord-015306-us58wwmp 3662 20 treatment treatment NN cord-015306-us58wwmp 3662 21 and and CC cord-015306-us58wwmp 3662 22 outcome outcome NN cord-015306-us58wwmp 3662 23 . . . cord-015306-us58wwmp 3663 1 Results result NNS cord-015306-us58wwmp 3663 2 : : : cord-015306-us58wwmp 3664 1 27/88 27/88 CD cord-015306-us58wwmp 3664 2 patients patient NNS cord-015306-us58wwmp 3664 3 had have VBD cord-015306-us58wwmp 3664 4 DSA DSA NNP cord-015306-us58wwmp 3664 5 tested test VBN cord-015306-us58wwmp 3664 6 ; ; : cord-015306-us58wwmp 3664 7 12/27 12/27 CD cord-015306-us58wwmp 3664 8 had have VBD cord-015306-us58wwmp 3664 9 dnDSA dndsa NN cord-015306-us58wwmp 3664 10 detected detect VBN cord-015306-us58wwmp 3664 11 . . . cord-015306-us58wwmp 3665 1 Median median JJ cord-015306-us58wwmp 3665 2 time time NN cord-015306-us58wwmp 3665 3 for for IN cord-015306-us58wwmp 3665 4 measured measure VBN cord-015306-us58wwmp 3665 5 of of IN cord-015306-us58wwmp 3665 6 dnDSA dndsa NN cord-015306-us58wwmp 3665 7 was be VBD cord-015306-us58wwmp 3665 8 7.6 7.6 CD cord-015306-us58wwmp 3665 9 years year NNS cord-015306-us58wwmp 3665 10 post post JJ cord-015306-us58wwmp 3665 11 - - NN cord-015306-us58wwmp 3665 12 transplant transplant JJ cord-015306-us58wwmp 3665 13 ( ( -LRB- cord-015306-us58wwmp 3665 14 range range NN cord-015306-us58wwmp 3665 15 1.07 1.07 CD cord-015306-us58wwmp 3665 16 - - HYPH cord-015306-us58wwmp 3665 17 13.02).Histology 13.02).histology CD cord-015306-us58wwmp 3665 18 : : : cord-015306-us58wwmp 3665 19 8/12 8/12 CD cord-015306-us58wwmp 3665 20 biopsies biopsy NNS cord-015306-us58wwmp 3665 21 in in IN cord-015306-us58wwmp 3665 22 dnDSA+ve dnDSA+ve NNS cord-015306-us58wwmp 3666 1 subgroup subgroup NNP cord-015306-us58wwmp 3666 2 had have VBD cord-015306-us58wwmp 3666 3 antibody antibody NN cord-015306-us58wwmp 3666 4 mediated mediate VBN cord-015306-us58wwmp 3666 5 rejection rejection NN cord-015306-us58wwmp 3666 6 ( ( -LRB- cord-015306-us58wwmp 3666 7 ABMR ABMR NNP cord-015306-us58wwmp 3666 8 ) ) -RRB- cord-015306-us58wwmp 3666 9 of of IN cord-015306-us58wwmp 3666 10 which which WDT cord-015306-us58wwmp 3666 11 6 6 CD cord-015306-us58wwmp 3666 12 were be VBD cord-015306-us58wwmp 3666 13 active active JJ cord-015306-us58wwmp 3666 14 ABMR ABMR NNP cord-015306-us58wwmp 3666 15 ( ( -LRB- cord-015306-us58wwmp 3666 16 3 3 CD cord-015306-us58wwmp 3666 17 were be VBD cord-015306-us58wwmp 3666 18 C4d C4d NNP cord-015306-us58wwmp 3666 19 positive positive JJ cord-015306-us58wwmp 3666 20 ) ) -RRB- cord-015306-us58wwmp 3666 21 compared compare VBN cord-015306-us58wwmp 3666 22 to to IN cord-015306-us58wwmp 3666 23 1/16 1/16 CD cord-015306-us58wwmp 3666 24 in in IN cord-015306-us58wwmp 3666 25 dnDSA dndsa NN cord-015306-us58wwmp 3666 26 - - HYPH cord-015306-us58wwmp 3666 27 ve ve JJ cord-015306-us58wwmp 3666 28 subgroup subgroup NN cord-015306-us58wwmp 3666 29 . . . cord-015306-us58wwmp 3667 1 The the DT cord-015306-us58wwmp 3667 2 following follow VBG cord-015306-us58wwmp 3667 3 treatments treatment NNS cord-015306-us58wwmp 3667 4 were be VBD cord-015306-us58wwmp 3667 5 used use VBN cord-015306-us58wwmp 3667 6 in in IN cord-015306-us58wwmp 3667 7 the the DT cord-015306-us58wwmp 3667 8 dnDSA+ve dnDSA+ve NNP cord-015306-us58wwmp 3667 9 group group NN cord-015306-us58wwmp 3667 10 : : : cord-015306-us58wwmp 3667 11 increase increase NN cord-015306-us58wwmp 3667 12 in in IN cord-015306-us58wwmp 3667 13 IS+ IS+ NNP cord-015306-us58wwmp 3667 14 pulsed pulse VBD cord-015306-us58wwmp 3667 15 methylprednisolone methylprednisolone NN cord-015306-us58wwmp 3667 16 ( ( -LRB- cord-015306-us58wwmp 3667 17 MP MP NNP cord-015306-us58wwmp 3667 18 ) ) -RRB- cord-015306-us58wwmp 3667 19 ( ( -LRB- cord-015306-us58wwmp 3667 20 5 5 CD cord-015306-us58wwmp 3667 21 patients patient NNS cord-015306-us58wwmp 3667 22 ) ) -RRB- cord-015306-us58wwmp 3667 23 , , , cord-015306-us58wwmp 3667 24 increase increase VB cord-015306-us58wwmp 3667 25 in in IN cord-015306-us58wwmp 3667 26 existing exist VBG cord-015306-us58wwmp 3667 27 IS be VBZ cord-015306-us58wwmp 3667 28 ( ( -LRB- cord-015306-us58wwmp 3667 29 2 2 CD cord-015306-us58wwmp 3667 30 ) ) -RRB- cord-015306-us58wwmp 3667 31 , , , cord-015306-us58wwmp 3667 32 rituximab rituximab VBN cord-015306-us58wwmp 3667 33 ( ( -LRB- cord-015306-us58wwmp 3667 34 2 2 CD cord-015306-us58wwmp 3667 35 ) ) -RRB- cord-015306-us58wwmp 3667 36 , , , cord-015306-us58wwmp 3667 37 pulsed pulse VBD cord-015306-us58wwmp 3667 38 MP MP NNP cord-015306-us58wwmp 3667 39 ( ( -LRB- cord-015306-us58wwmp 3667 40 1 1 CD cord-015306-us58wwmp 3667 41 ) ) -RRB- cord-015306-us58wwmp 3667 42 , , , cord-015306-us58wwmp 3667 43 sirolimus sirolimus NNP cord-015306-us58wwmp 3667 44 added+pulsed added+pulsed NNP cord-015306-us58wwmp 3667 45 MP MP NNP cord-015306-us58wwmp 3667 46 ( ( -LRB- cord-015306-us58wwmp 3667 47 1 1 CD cord-015306-us58wwmp 3667 48 ) ) -RRB- cord-015306-us58wwmp 3667 49 . . . cord-015306-us58wwmp 3668 1 In in IN cord-015306-us58wwmp 3668 2 one one CD cord-015306-us58wwmp 3668 3 patient patient NN cord-015306-us58wwmp 3668 4 no no DT cord-015306-us58wwmp 3668 5 change change NN cord-015306-us58wwmp 3668 6 was be VBD cord-015306-us58wwmp 3668 7 made make VBN cord-015306-us58wwmp 3668 8 . . . cord-015306-us58wwmp 3669 1 At at IN cord-015306-us58wwmp 3669 2 last last JJ cord-015306-us58wwmp 3669 3 follow follow NN cord-015306-us58wwmp 3669 4 up up RP cord-015306-us58wwmp 3669 5 , , , cord-015306-us58wwmp 3669 6 in in IN cord-015306-us58wwmp 3669 7 9/12 9/12 CD cord-015306-us58wwmp 3669 8 patients patient NNS cord-015306-us58wwmp 3669 9 with with IN cord-015306-us58wwmp 3669 10 dnDSA dndsa NN cord-015306-us58wwmp 3670 1 an an DT cord-015306-us58wwmp 3670 2 improvement improvement NN cord-015306-us58wwmp 3670 3 in in IN cord-015306-us58wwmp 3670 4 eGFR egfr NN cord-015306-us58wwmp 3670 5 was be VBD cord-015306-us58wwmp 3670 6 observed observe VBN cord-015306-us58wwmp 3670 7 . . . cord-015306-us58wwmp 3671 1 On on IN cord-015306-us58wwmp 3671 2 re re NN cord-015306-us58wwmp 3671 3 - - NN cord-015306-us58wwmp 3671 4 testing testing NN cord-015306-us58wwmp 3671 5 for for IN cord-015306-us58wwmp 3671 6 dnDSAs dnDSAs NNP cord-015306-us58wwmp 3671 7 , , , cord-015306-us58wwmp 3671 8 3/12 3/12 CD cord-015306-us58wwmp 3671 9 patients patient NNS cord-015306-us58wwmp 3671 10 tested test VBD cord-015306-us58wwmp 3671 11 negative negative JJ cord-015306-us58wwmp 3671 12 , , , cord-015306-us58wwmp 3671 13 2/12 2/12 CD cord-015306-us58wwmp 3671 14 had have VBD cord-015306-us58wwmp 3671 15 lower low JJR cord-015306-us58wwmp 3671 16 and and CC cord-015306-us58wwmp 3671 17 3/12 3/12 CD cord-015306-us58wwmp 3671 18 increased increase VBN cord-015306-us58wwmp 3671 19 levels level NNS cord-015306-us58wwmp 3671 20 . . . cord-015306-us58wwmp 3672 1 3/12 3/12 CD cord-015306-us58wwmp 3672 2 had have VBD cord-015306-us58wwmp 3672 3 not not RB cord-015306-us58wwmp 3672 4 yet yet RB cord-015306-us58wwmp 3672 5 had have VBN cord-015306-us58wwmp 3672 6 repeat repeat NN cord-015306-us58wwmp 3672 7 dnDSA dndsa JJ cord-015306-us58wwmp 3672 8 testing testing NN cord-015306-us58wwmp 3672 9 . . . cord-015306-us58wwmp 3673 1 Conclusion conclusion NN cord-015306-us58wwmp 3673 2 : : : cord-015306-us58wwmp 3674 1 Despite despite IN cord-015306-us58wwmp 3674 2 previous previous JJ cord-015306-us58wwmp 3674 3 reports report NNS cord-015306-us58wwmp 3674 4 of of IN cord-015306-us58wwmp 3674 5 dnDSA dndsa JJ cord-015306-us58wwmp 3674 6 conferring confer VBG cord-015306-us58wwmp 3674 7 poor poor JJ cord-015306-us58wwmp 3674 8 prognosis prognosis NN cord-015306-us58wwmp 3674 9 , , , cord-015306-us58wwmp 3674 10 in in IN cord-015306-us58wwmp 3674 11 our -PRON- PRP$ cord-015306-us58wwmp 3674 12 cohort cohort NN cord-015306-us58wwmp 3674 13 with with IN cord-015306-us58wwmp 3674 14 allograft allograft NN cord-015306-us58wwmp 3674 15 dysfunction dysfunction NN cord-015306-us58wwmp 3674 16 and and CC cord-015306-us58wwmp 3674 17 positive positive JJ cord-015306-us58wwmp 3674 18 dnDSA dndsa NN cord-015306-us58wwmp 3675 1 an an DT cord-015306-us58wwmp 3675 2 improvement improvement NN cord-015306-us58wwmp 3675 3 in in IN cord-015306-us58wwmp 3675 4 renal renal JJ cord-015306-us58wwmp 3675 5 function function NN cord-015306-us58wwmp 3675 6 was be VBD cord-015306-us58wwmp 3675 7 observed observe VBN cord-015306-us58wwmp 3675 8 in in IN cord-015306-us58wwmp 3675 9 75 75 CD cord-015306-us58wwmp 3675 10 % % NN cord-015306-us58wwmp 3675 11 . . . cord-015306-us58wwmp 3676 1 However however RB cord-015306-us58wwmp 3676 2 , , , cord-015306-us58wwmp 3676 3 larger large JJR cord-015306-us58wwmp 3676 4 prospective prospective JJ cord-015306-us58wwmp 3676 5 studies study NNS cord-015306-us58wwmp 3676 6 are be VBP cord-015306-us58wwmp 3676 7 required require VBN cord-015306-us58wwmp 3676 8 to to TO cord-015306-us58wwmp 3676 9 further further RB cord-015306-us58wwmp 3676 10 evaluate evaluate VB cord-015306-us58wwmp 3676 11 these these DT cord-015306-us58wwmp 3676 12 findings finding NNS cord-015306-us58wwmp 3676 13 . . . cord-015306-us58wwmp 3677 1 Abstract abstract JJ cord-015306-us58wwmp 3677 2 # # NN cord-015306-us58wwmp 3677 3 P p NN cord-015306-us58wwmp 3677 4 - - HYPH cord-015306-us58wwmp 3677 5 SAT425 SAT425 NNP cord-015306-us58wwmp 3677 6 Anuria Anuria NNP cord-015306-us58wwmp 3677 7 Since since IN cord-015306-us58wwmp 3677 8 Birth Birth NNP cord-015306-us58wwmp 3677 9 : : : cord-015306-us58wwmp 3678 1 Does do VBZ cord-015306-us58wwmp 3678 2 It -PRON- PRP cord-015306-us58wwmp 3678 3 Impact impact VB cord-015306-us58wwmp 3678 4 Outcome outcome NN cord-015306-us58wwmp 3678 5 Of of IN cord-015306-us58wwmp 3678 6 Kidney kidney NN cord-015306-us58wwmp 3678 7 Transplant transplant NN cord-015306-us58wwmp 3678 8 In in IN cord-015306-us58wwmp 3678 9 Infants infant NNS cord-015306-us58wwmp 3678 10 ? ? . cord-015306-us58wwmp 3679 1 Shefali Shefali NNP cord-015306-us58wwmp 3679 2 Vyas Vyas NNP cord-015306-us58wwmp 3679 3 , , , cord-015306-us58wwmp 3679 4 Maria Maria NNP cord-015306-us58wwmp 3679 5 Isabel Isabel NNP cord-015306-us58wwmp 3679 6 Roberti Roberti NNP cord-015306-us58wwmp 3679 7 Pediatric Pediatric NNP cord-015306-us58wwmp 3679 8 Nephrology Nephrology NNP cord-015306-us58wwmp 3679 9 , , , cord-015306-us58wwmp 3679 10 Saint Saint NNP cord-015306-us58wwmp 3679 11 Barnabas Barnabas NNP cord-015306-us58wwmp 3679 12 Medical Medical NNP cord-015306-us58wwmp 3679 13 Center Center NNP cord-015306-us58wwmp 3679 14 , , , cord-015306-us58wwmp 3679 15 Livingston Livingston NNP cord-015306-us58wwmp 3679 16 , , , cord-015306-us58wwmp 3680 1 USA USA NNP cord-015306-us58wwmp 3680 2 Objective Objective NNP cord-015306-us58wwmp 3680 3 : : : cord-015306-us58wwmp 3680 4 Scarcity scarcity NN cord-015306-us58wwmp 3680 5 of of IN cord-015306-us58wwmp 3680 6 data data NN cord-015306-us58wwmp 3680 7 exists exist VBZ cord-015306-us58wwmp 3680 8 for for IN cord-015306-us58wwmp 3680 9 allograft allograft NN cord-015306-us58wwmp 3680 10 outcomes outcome NNS cord-015306-us58wwmp 3680 11 and and CC cord-015306-us58wwmp 3680 12 urological urological JJ cord-015306-us58wwmp 3680 13 problems problem NNS cord-015306-us58wwmp 3680 14 in in IN cord-015306-us58wwmp 3680 15 children child NNS cord-015306-us58wwmp 3680 16 with with IN cord-015306-us58wwmp 3680 17 long long JJ cord-015306-us58wwmp 3680 18 term term NN cord-015306-us58wwmp 3680 19 de de IN cord-015306-us58wwmp 3680 20 functionalized functionalize VBN cord-015306-us58wwmp 3680 21 bladders bladder NNS cord-015306-us58wwmp 3680 22 . . . cord-015306-us58wwmp 3681 1 However however RB cord-015306-us58wwmp 3681 2 , , , cord-015306-us58wwmp 3681 3 even even RB cord-015306-us58wwmp 3681 4 less less RBR cord-015306-us58wwmp 3681 5 is be VBZ cord-015306-us58wwmp 3681 6 known know VBN cord-015306-us58wwmp 3681 7 about about IN cord-015306-us58wwmp 3681 8 the the DT cord-015306-us58wwmp 3681 9 outcome outcome NN cord-015306-us58wwmp 3681 10 of of IN cord-015306-us58wwmp 3681 11 infants infant NNS cord-015306-us58wwmp 3681 12 anuric anuric RB cord-015306-us58wwmp 3681 13 since since IN cord-015306-us58wwmp 3681 14 birth birth NN cord-015306-us58wwmp 3681 15 and and CC cord-015306-us58wwmp 3681 16 whose whose WP$ cord-015306-us58wwmp 3681 17 bladders bladder NNS cord-015306-us58wwmp 3681 18 underwent undergo VBD cord-015306-us58wwmp 3681 19 " " `` cord-015306-us58wwmp 3681 20 forced force VBN cord-015306-us58wwmp 3681 21 rehabilitation rehabilitation NN cord-015306-us58wwmp 3681 22 " " '' cord-015306-us58wwmp 3681 23 after after IN cord-015306-us58wwmp 3681 24 a a DT cord-015306-us58wwmp 3681 25 successful successful JJ cord-015306-us58wwmp 3681 26 renal renal JJ cord-015306-us58wwmp 3681 27 transplant transplant NN cord-015306-us58wwmp 3681 28 . . . cord-015306-us58wwmp 3682 1 Methods method NNS cord-015306-us58wwmp 3682 2 : : : cord-015306-us58wwmp 3682 3 In in IN cord-015306-us58wwmp 3682 4 this this DT cord-015306-us58wwmp 3682 5 retrospective retrospective JJ cord-015306-us58wwmp 3682 6 study study NN cord-015306-us58wwmp 3682 7 we -PRON- PRP cord-015306-us58wwmp 3682 8 compared compare VBD cord-015306-us58wwmp 3682 9 urological urological JJ cord-015306-us58wwmp 3682 10 events event NNS cord-015306-us58wwmp 3682 11 and and CC cord-015306-us58wwmp 3682 12 allograft allograft NN cord-015306-us58wwmp 3682 13 outcome outcome NN cord-015306-us58wwmp 3682 14 in in IN cord-015306-us58wwmp 3682 15 infants infant NNS cord-015306-us58wwmp 3682 16 with with IN cord-015306-us58wwmp 3682 17 ESRD ESRD NNP cord-015306-us58wwmp 3682 18 mainly mainly RB cord-015306-us58wwmp 3682 19 due due JJ cord-015306-us58wwmp 3682 20 to to IN cord-015306-us58wwmp 3682 21 urological urological JJ cord-015306-us58wwmp 3682 22 problems problem NNS cord-015306-us58wwmp 3682 23 . . . cord-015306-us58wwmp 3683 1 They -PRON- PRP cord-015306-us58wwmp 3683 2 were be VBD cord-015306-us58wwmp 3683 3 grouped group VBN cord-015306-us58wwmp 3683 4 according accord VBG cord-015306-us58wwmp 3683 5 to to IN cord-015306-us58wwmp 3683 6 the the DT cord-015306-us58wwmp 3683 7 history history NN cord-015306-us58wwmp 3683 8 of of IN cord-015306-us58wwmp 3683 9 pre pre JJ cord-015306-us58wwmp 3683 10 - - JJ cord-015306-us58wwmp 3683 11 txp txp JJ cord-015306-us58wwmp 3683 12 urine urine NN cord-015306-us58wwmp 3683 13 out out RP cord-015306-us58wwmp 3683 14 put put NN cord-015306-us58wwmp 3683 15 : : : cord-015306-us58wwmp 3684 1 Group group NN cord-015306-us58wwmp 3684 2 A a DT cord-015306-us58wwmp 3684 3 with with IN cord-015306-us58wwmp 3684 4 urine urine NN cord-015306-us58wwmp 3684 5 output output NN cord-015306-us58wwmp 3684 6 prior prior RB cord-015306-us58wwmp 3684 7 to to IN cord-015306-us58wwmp 3684 8 txp txp NNP cord-015306-us58wwmp 3684 9 and and CC cord-015306-us58wwmp 3684 10 Group Group NNP cord-015306-us58wwmp 3684 11 B B NNP cord-015306-us58wwmp 3684 12 anuric anuric RB cord-015306-us58wwmp 3684 13 since since IN cord-015306-us58wwmp 3684 14 birth birth NN cord-015306-us58wwmp 3685 1 ( ( -LRB- cord-015306-us58wwmp 3685 2 all all DT cord-015306-us58wwmp 3685 3 had have VBD cord-015306-us58wwmp 3685 4 visible visible JJ cord-015306-us58wwmp 3685 5 small small JJ cord-015306-us58wwmp 3685 6 bladders bladder NNS cord-015306-us58wwmp 3685 7 by by IN cord-015306-us58wwmp 3685 8 ultra ultra JJ cord-015306-us58wwmp 3685 9 sonogram sonogram NN cord-015306-us58wwmp 3685 10 ) ) -RRB- cord-015306-us58wwmp 3685 11 . . . cord-015306-us58wwmp 3686 1 Results result NNS cord-015306-us58wwmp 3686 2 : : : cord-015306-us58wwmp 3687 1 There there EX cord-015306-us58wwmp 3687 2 were be VBD cord-015306-us58wwmp 3687 3 no no DT cord-015306-us58wwmp 3687 4 significant significant JJ cord-015306-us58wwmp 3687 5 differences difference NNS cord-015306-us58wwmp 3687 6 regarding regard VBG cord-015306-us58wwmp 3687 7 birth birth NN cord-015306-us58wwmp 3687 8 history history NN cord-015306-us58wwmp 3687 9 or or CC cord-015306-us58wwmp 3687 10 ethnicity ethnicity NN cord-015306-us58wwmp 3687 11 . . . cord-015306-us58wwmp 3688 1 Group Group NNP cord-015306-us58wwmp 3688 2 A A NNP cord-015306-us58wwmp 3688 3 had have VBD cord-015306-us58wwmp 3688 4 13 13 CD cord-015306-us58wwmp 3688 5 boys boy NNS cord-015306-us58wwmp 3688 6 ( ( -LRB- cord-015306-us58wwmp 3688 7 87 87 CD cord-015306-us58wwmp 3688 8 % % NN cord-015306-us58wwmp 3688 9 ) ) -RRB- cord-015306-us58wwmp 3688 10 and and CC cord-015306-us58wwmp 3688 11 group group NN cord-015306-us58wwmp 3688 12 B B NNP cord-015306-us58wwmp 3688 13 had have VBD cord-015306-us58wwmp 3688 14 all all DT cord-015306-us58wwmp 3688 15 girls girl NNS cord-015306-us58wwmp 3688 16 ; ; , cord-015306-us58wwmp 3688 17 All all DT cord-015306-us58wwmp 3688 18 but but IN cord-015306-us58wwmp 3688 19 one one CD cord-015306-us58wwmp 3688 20 child child NN cord-015306-us58wwmp 3688 21 in in IN cord-015306-us58wwmp 3688 22 group group NN cord-015306-us58wwmp 3688 23 B B NNP cord-015306-us58wwmp 3688 24 received receive VBD cord-015306-us58wwmp 3688 25 LRD LRD NNP cord-015306-us58wwmp 3688 26 Txp Txp NNP cord-015306-us58wwmp 3688 27 . . . cord-015306-us58wwmp 3689 1 All all DT cord-015306-us58wwmp 3689 2 received receive VBD cord-015306-us58wwmp 3689 3 induction induction NN cord-015306-us58wwmp 3689 4 followed follow VBN cord-015306-us58wwmp 3689 5 by by IN cord-015306-us58wwmp 3689 6 triple triple JJ cord-015306-us58wwmp 3689 7 therapy therapy NN cord-015306-us58wwmp 3689 8 ( ( -LRB- cord-015306-us58wwmp 3689 9 tacrolimus tacrolimus NNP cord-015306-us58wwmp 3689 10 , , , cord-015306-us58wwmp 3689 11 steroids steroid NNS cord-015306-us58wwmp 3689 12 and and CC cord-015306-us58wwmp 3689 13 MMF MMF NNP cord-015306-us58wwmp 3689 14 ) ) -RRB- cord-015306-us58wwmp 3689 15 . . . cord-015306-us58wwmp 3690 1 Group Group NNP cord-015306-us58wwmp 3690 2 A a NN cord-015306-us58wwmp 3690 3 : : : cord-015306-us58wwmp 3690 4 8/15 8/15 CD cord-015306-us58wwmp 3690 5 had have VBD cord-015306-us58wwmp 3690 6 V v NN cord-015306-us58wwmp 3690 7 - - HYPH cord-015306-us58wwmp 3690 8 U u NN cord-015306-us58wwmp 3690 9 reflux reflux NN cord-015306-us58wwmp 3690 10 and and CC cord-015306-us58wwmp 3690 11 13/15 13/15 CD cord-015306-us58wwmp 3690 12 were be VBD cord-015306-us58wwmp 3690 13 on on IN cord-015306-us58wwmp 3690 14 PD PD NNP cord-015306-us58wwmp 3690 15 prior prior RB cord-015306-us58wwmp 3690 16 to to IN cord-015306-us58wwmp 3690 17 txp txp NNP cord-015306-us58wwmp 3690 18 ( ( -LRB- cord-015306-us58wwmp 3691 1 mean mean VBP cord-015306-us58wwmp 3691 2 time= time= NNP cord-015306-us58wwmp 3691 3 7 7 CD cord-015306-us58wwmp 3691 4 mos mos NNP cord-015306-us58wwmp 3691 5 ) ) -RRB- cord-015306-us58wwmp 3691 6 . . . cord-015306-us58wwmp 3692 1 All all DT cord-015306-us58wwmp 3692 2 patients patient NNS cord-015306-us58wwmp 3692 3 in in IN cord-015306-us58wwmp 3692 4 Group Group NNP cord-015306-us58wwmp 3692 5 B B NNP cord-015306-us58wwmp 3692 6 were be VBD cord-015306-us58wwmp 3692 7 started start VBN cord-015306-us58wwmp 3692 8 on on IN cord-015306-us58wwmp 3692 9 PD PD NNP cord-015306-us58wwmp 3692 10 in in IN cord-015306-us58wwmp 3692 11 the the DT cord-015306-us58wwmp 3692 12 neonatal neonatal JJ cord-015306-us58wwmp 3692 13 period period NN cord-015306-us58wwmp 3692 14 ( ( -LRB- cord-015306-us58wwmp 3692 15 mean mean VB cord-015306-us58wwmp 3692 16 = = SYM cord-015306-us58wwmp 3692 17 9.8 9.8 CD cord-015306-us58wwmp 3692 18 days day NNS cord-015306-us58wwmp 3692 19 ) ) -RRB- cord-015306-us58wwmp 3692 20 . . . cord-015306-us58wwmp 3693 1 Pre pre JJ cord-015306-us58wwmp 3693 2 txp txp NNP cord-015306-us58wwmp 3693 3 native native JJ cord-015306-us58wwmp 3693 4 nephrectomies nephrectomy NNS cord-015306-us58wwmp 3693 5 were be VBD cord-015306-us58wwmp 3693 6 done do VBN cord-015306-us58wwmp 3693 7 in in IN cord-015306-us58wwmp 3693 8 3 3 CD cord-015306-us58wwmp 3693 9 patients patient NNS cord-015306-us58wwmp 3693 10 ( ( -LRB- cord-015306-us58wwmp 3693 11 2 2 CD cord-015306-us58wwmp 3693 12 in in IN cord-015306-us58wwmp 3693 13 Group Group NNP cord-015306-us58wwmp 3693 14 A A NNP cord-015306-us58wwmp 3693 15 and and CC cord-015306-us58wwmp 3693 16 1 1 CD cord-015306-us58wwmp 3693 17 in in IN cord-015306-us58wwmp 3693 18 Group Group NNP cord-015306-us58wwmp 3693 19 B B NNP cord-015306-us58wwmp 3693 20 ) ) -RRB- cord-015306-us58wwmp 3693 21 . . . cord-015306-us58wwmp 3694 1 Group Group NNP cord-015306-us58wwmp 3694 2 A A NNP cord-015306-us58wwmp 3694 3 had have VBD cord-015306-us58wwmp 3694 4 2 2 CD cord-015306-us58wwmp 3694 5 acute acute JJ cord-015306-us58wwmp 3694 6 rejections rejection NNS cord-015306-us58wwmp 3694 7 and and CC cord-015306-us58wwmp 3694 8 none none NN cord-015306-us58wwmp 3694 9 in in IN cord-015306-us58wwmp 3694 10 Group Group NNP cord-015306-us58wwmp 3694 11 B. B. NNP cord-015306-us58wwmp 3694 12 Conclusion Conclusion NNP cord-015306-us58wwmp 3694 13 : : : cord-015306-us58wwmp 3695 1 Anuric anuric JJ cord-015306-us58wwmp 3695 2 young young JJ cord-015306-us58wwmp 3695 3 infants infant NNS cord-015306-us58wwmp 3695 4 had have VBD cord-015306-us58wwmp 3695 5 higher high JJR cord-015306-us58wwmp 3695 6 rates rate NNS cord-015306-us58wwmp 3695 7 of of IN cord-015306-us58wwmp 3695 8 post post NN cord-015306-us58wwmp 3695 9 txp txp NNP cord-015306-us58wwmp 3695 10 UTIs uti NNS cord-015306-us58wwmp 3695 11 and and CC cord-015306-us58wwmp 3695 12 V v NN cord-015306-us58wwmp 3695 13 - - HYPH cord-015306-us58wwmp 3695 14 U U NNP cord-015306-us58wwmp 3695 15 Reflux reflux NN cord-015306-us58wwmp 3695 16 , , , cord-015306-us58wwmp 3695 17 a a DT cord-015306-us58wwmp 3695 18 direct direct JJ cord-015306-us58wwmp 3695 19 consequence consequence NN cord-015306-us58wwmp 3695 20 of of IN cord-015306-us58wwmp 3695 21 their -PRON- PRP$ cord-015306-us58wwmp 3695 22 inherent inherent JJ cord-015306-us58wwmp 3695 23 small small JJ cord-015306-us58wwmp 3695 24 bladders bladder NNS cord-015306-us58wwmp 3695 25 . . . cord-015306-us58wwmp 3696 1 However however RB cord-015306-us58wwmp 3696 2 , , , cord-015306-us58wwmp 3696 3 the the DT cord-015306-us58wwmp 3696 4 3 3 CD cord-015306-us58wwmp 3696 5 year year NN cord-015306-us58wwmp 3696 6 graft graft NN cord-015306-us58wwmp 3696 7 survival survival NN cord-015306-us58wwmp 3696 8 , , , cord-015306-us58wwmp 3696 9 patient patient JJ cord-015306-us58wwmp 3696 10 survival survival NN cord-015306-us58wwmp 3696 11 and and CC cord-015306-us58wwmp 3696 12 GFR GFR NNP cord-015306-us58wwmp 3696 13 remained remain VBD cord-015306-us58wwmp 3696 14 excellent excellent JJ cord-015306-us58wwmp 3696 15 in in IN cord-015306-us58wwmp 3696 16 anuric anuric JJ cord-015306-us58wwmp 3696 17 infants infant NNS cord-015306-us58wwmp 3696 18 ( ( -LRB- cord-015306-us58wwmp 3696 19 Group Group NNP cord-015306-us58wwmp 3696 20 B B NNP cord-015306-us58wwmp 3696 21 ) ) -RRB- cord-015306-us58wwmp 3696 22 compared compare VBN cord-015306-us58wwmp 3696 23 to to IN cord-015306-us58wwmp 3696 24 young young JJ cord-015306-us58wwmp 3696 25 infants infant NNS cord-015306-us58wwmp 3696 26 transplanted transplant VBN cord-015306-us58wwmp 3696 27 with with IN cord-015306-us58wwmp 3696 28 higher high JJR cord-015306-us58wwmp 3696 29 rates rate NNS cord-015306-us58wwmp 3696 30 of of IN cord-015306-us58wwmp 3696 31 V v NN cord-015306-us58wwmp 3696 32 - - HYPH cord-015306-us58wwmp 3696 33 U u NN cord-015306-us58wwmp 3696 34 Reflux reflux NN cord-015306-us58wwmp 3696 35 and and CC cord-015306-us58wwmp 3696 36 dysfunctional dysfunctional JJ cord-015306-us58wwmp 3696 37 bladders bladder NNS cord-015306-us58wwmp 3696 38 pre pre VBP cord-015306-us58wwmp 3696 39 txp txp NN cord-015306-us58wwmp 3696 40 . . . cord-015306-us58wwmp 3697 1 Abstract abstract JJ cord-015306-us58wwmp 3697 2 # # NN cord-015306-us58wwmp 3697 3 P p NN cord-015306-us58wwmp 3697 4 - - HYPH cord-015306-us58wwmp 3697 5 SAT426 SAT426 NNP cord-015306-us58wwmp 3697 6 Kidney kidney NN cord-015306-us58wwmp 3697 7 transplantation transplantation NN cord-015306-us58wwmp 3697 8 in in IN cord-015306-us58wwmp 3697 9 a a DT cord-015306-us58wwmp 3697 10 child child NN cord-015306-us58wwmp 3697 11 with with IN cord-015306-us58wwmp 3697 12 bladder bladder NN cord-015306-us58wwmp 3697 13 dysfunction dysfunction NN cord-015306-us58wwmp 3697 14 who who WP cord-015306-us58wwmp 3697 15 underwent undergo VBD cord-015306-us58wwmp 3697 16 prior prior JJ cord-015306-us58wwmp 3697 17 bladder bladder NN cord-015306-us58wwmp 3697 18 augmentation augmentation NN cord-015306-us58wwmp 3697 19 : : : cord-015306-us58wwmp 3697 20 A a DT cord-015306-us58wwmp 3697 21 case case NN cord-015306-us58wwmp 3697 22 report report NN cord-015306-us58wwmp 3697 23 1 1 CD cord-015306-us58wwmp 3697 24 Tepecik Tepecik NNP cord-015306-us58wwmp 3697 25 Training Training NNP cord-015306-us58wwmp 3697 26 and and CC cord-015306-us58wwmp 3697 27 Research Research NNP cord-015306-us58wwmp 3697 28 Hospital Hospital NNP cord-015306-us58wwmp 3697 29 , , , cord-015306-us58wwmp 3697 30 Pediatric Pediatric NNP cord-015306-us58wwmp 3697 31 Nephrology Nephrology NNP cord-015306-us58wwmp 3697 32 , , , cord-015306-us58wwmp 3697 33 They -PRON- PRP cord-015306-us58wwmp 3697 34 were be VBD cord-015306-us58wwmp 3697 35 divided divide VBN cord-015306-us58wwmp 3697 36 into into IN cord-015306-us58wwmp 3697 37 2 2 CD cord-015306-us58wwmp 3697 38 groups group NNS cord-015306-us58wwmp 3697 39 ; ; : cord-015306-us58wwmp 3697 40 12pts 12pts CD cord-015306-us58wwmp 3697 41 with with IN cord-015306-us58wwmp 3697 42 ESRD ESRD NNP cord-015306-us58wwmp 3697 43 on on IN cord-015306-us58wwmp 3697 44 dialysis dialysis NN cord-015306-us58wwmp 3697 45 ( ( -LRB- cord-015306-us58wwmp 3697 46 D D NNP cord-015306-us58wwmp 3697 47 ) ) -RRB- cord-015306-us58wwmp 3697 48 , , , cord-015306-us58wwmp 3697 49 4/12 4/12 CD cord-015306-us58wwmp 3697 50 with with IN cord-015306-us58wwmp 3697 51 history history NN cord-015306-us58wwmp 3697 52 of of IN cord-015306-us58wwmp 3697 53 kidney kidney NN cord-015306-us58wwmp 3697 54 transplant transplant NN cord-015306-us58wwmp 3697 55 , , , cord-015306-us58wwmp 3697 56 and and CC cord-015306-us58wwmp 3697 57 9 9 CD cord-015306-us58wwmp 3697 58 kidney kidney NN cord-015306-us58wwmp 3697 59 transplant transplant NN cord-015306-us58wwmp 3697 60 recipients recipient NNS cord-015306-us58wwmp 3697 61 with with IN cord-015306-us58wwmp 3697 62 good good JJ cord-015306-us58wwmp 3697 63 graft graft NN cord-015306-us58wwmp 3697 64 function function NN cord-015306-us58wwmp 3697 65 ( ( -LRB- cord-015306-us58wwmp 3697 66 T T NNP cord-015306-us58wwmp 3697 67 ) ) -RRB- cord-015306-us58wwmp 3697 68 . . . cord-015306-us58wwmp 3698 1 All all DT cord-015306-us58wwmp 3698 2 subjects subject NNS cord-015306-us58wwmp 3698 3 were be VBD cord-015306-us58wwmp 3698 4 tested test VBN cord-015306-us58wwmp 3698 5 for for IN cord-015306-us58wwmp 3698 6 anti anti JJ cord-015306-us58wwmp 3698 7 - - JJ cord-015306-us58wwmp 3698 8 HLA HLA NNP cord-015306-us58wwmp 3698 9 antibody antibody NN cord-015306-us58wwmp 3698 10 1 1 CD cord-015306-us58wwmp 3698 11 month month NN cord-015306-us58wwmp 3698 12 prior prior RB cord-015306-us58wwmp 3698 13 to to IN cord-015306-us58wwmp 3698 14 and and CC cord-015306-us58wwmp 3698 15 1 1 CD cord-015306-us58wwmp 3698 16 month month NN cord-015306-us58wwmp 3698 17 and and CC cord-015306-us58wwmp 3698 18 6 6 CD cord-015306-us58wwmp 3698 19 months month NNS cord-015306-us58wwmp 3698 20 after after IN cord-015306-us58wwmp 3698 21 administration administration NN cord-015306-us58wwmp 3698 22 of of IN cord-015306-us58wwmp 3698 23 the the DT cord-015306-us58wwmp 3698 24 combination combination NN cord-015306-us58wwmp 3698 25 vaccine vaccine NN cord-015306-us58wwmp 3698 26 of of IN cord-015306-us58wwmp 3698 27 Influenza Influenza NNP cord-015306-us58wwmp 3698 28 A/ A/ NNP cord-015306-us58wwmp 3698 29 H1N1 H1N1 NNP cord-015306-us58wwmp 3698 30 . . . cord-015306-us58wwmp 3699 1 Results result NNS cord-015306-us58wwmp 3699 2 : : : cord-015306-us58wwmp 3700 1 Among among IN cord-015306-us58wwmp 3700 2 the the DT cord-015306-us58wwmp 3700 3 T T NNP cord-015306-us58wwmp 3700 4 group group NN cord-015306-us58wwmp 3700 5 , , , cord-015306-us58wwmp 3700 6 no no DT cord-015306-us58wwmp 3700 7 pt pt RB cord-015306-us58wwmp 3700 8 tested test VBD cord-015306-us58wwmp 3700 9 positive positive JJ cord-015306-us58wwmp 3700 10 for for IN cord-015306-us58wwmp 3700 11 either either DT cord-015306-us58wwmp 3700 12 anti anti JJ cord-015306-us58wwmp 3700 13 - - JJ cord-015306-us58wwmp 3700 14 HLA hla JJ cord-015306-us58wwmp 3700 15 class class NN cord-015306-us58wwmp 3700 16 I i NN cord-015306-us58wwmp 3700 17 or or CC cord-015306-us58wwmp 3700 18 class class NN cord-015306-us58wwmp 3700 19 II ii CD cord-015306-us58wwmp 3700 20 antibodies antibody NNS cord-015306-us58wwmp 3700 21 before before IN cord-015306-us58wwmp 3700 22 or or CC cord-015306-us58wwmp 3700 23 after after IN cord-015306-us58wwmp 3701 1 Influenza Influenza NNP cord-015306-us58wwmp 3701 2 A/ A/ NNP cord-015306-us58wwmp 3701 3 H1N1 H1N1 NNP cord-015306-us58wwmp 3701 4 vaccine vaccine NN cord-015306-us58wwmp 3701 5 . . . cord-015306-us58wwmp 3702 1 In in IN cord-015306-us58wwmp 3702 2 the the DT cord-015306-us58wwmp 3702 3 D D NNP cord-015306-us58wwmp 3702 4 group group NN cord-015306-us58wwmp 3702 5 , , , cord-015306-us58wwmp 3702 6 of of IN cord-015306-us58wwmp 3702 7 the the DT cord-015306-us58wwmp 3702 8 4 4 CD cord-015306-us58wwmp 3702 9 pts pt NNS cord-015306-us58wwmp 3702 10 with with IN cord-015306-us58wwmp 3702 11 a a DT cord-015306-us58wwmp 3702 12 history history NN cord-015306-us58wwmp 3702 13 of of IN cord-015306-us58wwmp 3702 14 graft graft NN cord-015306-us58wwmp 3702 15 failure failure NN cord-015306-us58wwmp 3702 16 who who WP cord-015306-us58wwmp 3702 17 were be VBD cord-015306-us58wwmp 3702 18 sensitized sensitize VBN cord-015306-us58wwmp 3702 19 before before IN cord-015306-us58wwmp 3702 20 immunization immunization NN cord-015306-us58wwmp 3702 21 ; ; : cord-015306-us58wwmp 3702 22 2 2 CD cord-015306-us58wwmp 3702 23 showed show VBD cord-015306-us58wwmp 3702 24 no no DT cord-015306-us58wwmp 3702 25 change change NN cord-015306-us58wwmp 3702 26 in in IN cord-015306-us58wwmp 3702 27 class class NN cord-015306-us58wwmp 3702 28 I i NN cord-015306-us58wwmp 3702 29 & & CC cord-015306-us58wwmp 3702 30 II II NNP cord-015306-us58wwmp 3702 31 , , , cord-015306-us58wwmp 3702 32 one one CD cord-015306-us58wwmp 3702 33 patient patient NN cord-015306-us58wwmp 3702 34 had have VBD cord-015306-us58wwmp 3702 35 mild mild JJ cord-015306-us58wwmp 3702 36 increase increase NN cord-015306-us58wwmp 3702 37 in in IN cord-015306-us58wwmp 3702 38 class class NN cord-015306-us58wwmp 3702 39 I -PRON- PRP cord-015306-us58wwmp 3702 40 after after IN cord-015306-us58wwmp 3702 41 vaccination vaccination NN cord-015306-us58wwmp 3702 42 , , , cord-015306-us58wwmp 3702 43 and and CC cord-015306-us58wwmp 3702 44 one one CD cord-015306-us58wwmp 3702 45 patient patient NN cord-015306-us58wwmp 3702 46 had have VBD cord-015306-us58wwmp 3702 47 an an DT cord-015306-us58wwmp 3702 48 increase increase NN cord-015306-us58wwmp 3702 49 in in IN cord-015306-us58wwmp 3702 50 class class NN cord-015306-us58wwmp 3702 51 I -PRON- PRP cord-015306-us58wwmp 3702 52 by by IN cord-015306-us58wwmp 3702 53 24 24 CD cord-015306-us58wwmp 3702 54 % % NN cord-015306-us58wwmp 3702 55 . . . cord-015306-us58wwmp 3703 1 [ [ -LRB- cord-015306-us58wwmp 3703 2 figure figure NN cord-015306-us58wwmp 3703 3 ] ] -RRB- cord-015306-us58wwmp 3703 4 Conclusion conclusion NN cord-015306-us58wwmp 3703 5 : : : cord-015306-us58wwmp 3704 1 None none NN cord-015306-us58wwmp 3704 2 of of IN cord-015306-us58wwmp 3704 3 the the DT cord-015306-us58wwmp 3704 4 T T NNP cord-015306-us58wwmp 3704 5 pts pts NN cord-015306-us58wwmp 3704 6 had have VBD cord-015306-us58wwmp 3704 7 clinical clinical JJ cord-015306-us58wwmp 3704 8 evidence evidence NN cord-015306-us58wwmp 3704 9 of of IN cord-015306-us58wwmp 3704 10 either either DT cord-015306-us58wwmp 3704 11 cell cell NN cord-015306-us58wwmp 3704 12 mediated mediate VBN cord-015306-us58wwmp 3704 13 or or CC cord-015306-us58wwmp 3704 14 humoral humoral JJ cord-015306-us58wwmp 3704 15 rejection rejection NN cord-015306-us58wwmp 3704 16 after after IN cord-015306-us58wwmp 3704 17 the the DT cord-015306-us58wwmp 3704 18 Influenza Influenza NNP cord-015306-us58wwmp 3704 19 A A NNP cord-015306-us58wwmp 3704 20 / / SYM cord-015306-us58wwmp 3704 21 H1N1 H1N1 NNP cord-015306-us58wwmp 3704 22 vaccine vaccine NN cord-015306-us58wwmp 3704 23 . . . cord-015306-us58wwmp 3705 1 In in IN cord-015306-us58wwmp 3705 2 the the DT cord-015306-us58wwmp 3705 3 D D NNP cord-015306-us58wwmp 3705 4 group group NN cord-015306-us58wwmp 3705 5 , , , cord-015306-us58wwmp 3705 6 no no DT cord-015306-us58wwmp 3705 7 pt pt NN cord-015306-us58wwmp 3705 8 had have VBD cord-015306-us58wwmp 3705 9 any any DT cord-015306-us58wwmp 3705 10 statistically statistically RB cord-015306-us58wwmp 3705 11 significant significant JJ cord-015306-us58wwmp 3705 12 increase increase NN cord-015306-us58wwmp 3705 13 in in IN cord-015306-us58wwmp 3705 14 anti anti JJ cord-015306-us58wwmp 3705 15 - - JJ cord-015306-us58wwmp 3705 16 HLA HLA NNP cord-015306-us58wwmp 3705 17 antibody antibody NN cord-015306-us58wwmp 3705 18 following follow VBG cord-015306-us58wwmp 3705 19 vaccination vaccination NN cord-015306-us58wwmp 3705 20 . . . cord-015306-us58wwmp 3706 1 Our -PRON- PRP$ cord-015306-us58wwmp 3706 2 study study NN cord-015306-us58wwmp 3706 3 suggests suggest VBZ cord-015306-us58wwmp 3706 4 that that IN cord-015306-us58wwmp 3706 5 Influenza Influenza NNP cord-015306-us58wwmp 3706 6 A A NNP cord-015306-us58wwmp 3706 7 / / SYM cord-015306-us58wwmp 3706 8 H1N1 H1N1 NNP cord-015306-us58wwmp 3706 9 vaccination vaccination NN cord-015306-us58wwmp 3706 10 may may MD cord-015306-us58wwmp 3706 11 be be VB cord-015306-us58wwmp 3706 12 safe safe JJ cord-015306-us58wwmp 3706 13 and and CC cord-015306-us58wwmp 3706 14 tolerable tolerable JJ cord-015306-us58wwmp 3706 15 in in IN cord-015306-us58wwmp 3706 16 pediatric pediatric JJ cord-015306-us58wwmp 3706 17 dialysis dialysis NN cord-015306-us58wwmp 3706 18 pts pt NNS cord-015306-us58wwmp 3706 19 with with IN cord-015306-us58wwmp 3706 20 or or CC cord-015306-us58wwmp 3706 21 without without IN cord-015306-us58wwmp 3706 22 a a DT cord-015306-us58wwmp 3706 23 failed fail VBN cord-015306-us58wwmp 3706 24 kidney kidney NN cord-015306-us58wwmp 3706 25 allograft allograft NN cord-015306-us58wwmp 3706 26 . . . cord-015306-us58wwmp 3707 1 The the DT cord-015306-us58wwmp 3707 2 effect effect NN cord-015306-us58wwmp 3707 3 of of IN cord-015306-us58wwmp 3707 4 dipping dip VBG cord-015306-us58wwmp 3707 5 blood blood NN cord-015306-us58wwmp 3707 6 pressure pressure NN cord-015306-us58wwmp 3707 7 status status NN cord-015306-us58wwmp 3707 8 on on IN cord-015306-us58wwmp 3707 9 structural structural JJ cord-015306-us58wwmp 3707 10 and and CC cord-015306-us58wwmp 3707 11 diastolic diastolic JJ cord-015306-us58wwmp 3707 12 heart heart NN cord-015306-us58wwmp 3707 13 function function NN cord-015306-us58wwmp 3707 14 in in IN cord-015306-us58wwmp 3707 15 renal renal JJ cord-015306-us58wwmp 3707 16 transplant transplant NN cord-015306-us58wwmp 3707 17 recipients recipient NNS cord-015306-us58wwmp 3707 18 Mitra Mitra NNP cord-015306-us58wwmp 3707 19 Basiratnia Basiratnia NNP cord-015306-us58wwmp 3707 20 1 1 CD cord-015306-us58wwmp 3707 21 , , , cord-015306-us58wwmp 3707 22 GholamHossein GholamHossein NNP cord-015306-us58wwmp 3707 23 Ajami Ajami NNP cord-015306-us58wwmp 3707 24 2 2 CD cord-015306-us58wwmp 3707 25 1 1 CD cord-015306-us58wwmp 3707 26 Shiraz Shiraz NNP cord-015306-us58wwmp 3707 27 nephrology nephrology NNP cord-015306-us58wwmp 3707 28 urology urology NNP cord-015306-us58wwmp 3707 29 research research NN cord-015306-us58wwmp 3707 30 center center NN cord-015306-us58wwmp 3707 31 , , , cord-015306-us58wwmp 3707 32 Shiraz Shiraz NNP cord-015306-us58wwmp 3707 33 university university NNP cord-015306-us58wwmp 3707 34 of of IN cord-015306-us58wwmp 3707 35 medical medical JJ cord-015306-us58wwmp 3707 36 sciences sciences NNPS cord-015306-us58wwmp 3707 37 , , , cord-015306-us58wwmp 3707 38 Shiraz Shiraz NNP cord-015306-us58wwmp 3707 39 , , , cord-015306-us58wwmp 3707 40 Iran Iran NNP cord-015306-us58wwmp 3707 41 2 2 CD cord-015306-us58wwmp 3707 42 Department Department NNP cord-015306-us58wwmp 3707 43 of of IN cord-015306-us58wwmp 3707 44 pediatric pediatric JJ cord-015306-us58wwmp 3707 45 cardiology cardiology NN cord-015306-us58wwmp 3707 46 , , , cord-015306-us58wwmp 3707 47 Shiraz Shiraz NNP cord-015306-us58wwmp 3707 48 university university NNP cord-015306-us58wwmp 3707 49 of of IN cord-015306-us58wwmp 3707 50 medical medical JJ cord-015306-us58wwmp 3707 51 sciences sciences NNPS cord-015306-us58wwmp 3707 52 , , , cord-015306-us58wwmp 3707 53 Shiraz Shiraz NNP cord-015306-us58wwmp 3707 54 , , , cord-015306-us58wwmp 3708 1 Iran Iran NNP cord-015306-us58wwmp 3708 2 Objectives Objectives NNP cord-015306-us58wwmp 3709 1 : : : cord-015306-us58wwmp 3709 2 Non non JJ cord-015306-us58wwmp 3709 3 dipping dipping NN cord-015306-us58wwmp 3709 4 has have VBZ cord-015306-us58wwmp 3709 5 been be VBN cord-015306-us58wwmp 3709 6 linked link VBN cord-015306-us58wwmp 3709 7 to to IN cord-015306-us58wwmp 3709 8 cardiovascular cardiovascular JJ cord-015306-us58wwmp 3709 9 disease disease NN cord-015306-us58wwmp 3709 10 in in IN cord-015306-us58wwmp 3709 11 adults adult NNS cord-015306-us58wwmp 3709 12 , , , cord-015306-us58wwmp 3709 13 however however RB cord-015306-us58wwmp 3709 14 the the DT cord-015306-us58wwmp 3709 15 impact impact NN cord-015306-us58wwmp 3709 16 of of IN cord-015306-us58wwmp 3709 17 non non JJ cord-015306-us58wwmp 3709 18 - - JJ cord-015306-us58wwmp 3709 19 dipping dipping JJ cord-015306-us58wwmp 3709 20 on on IN cord-015306-us58wwmp 3709 21 cardiovascular cardiovascular JJ cord-015306-us58wwmp 3709 22 status status NN cord-015306-us58wwmp 3709 23 of of IN cord-015306-us58wwmp 3709 24 the the DT cord-015306-us58wwmp 3709 25 adolescents adolescent NNS cord-015306-us58wwmp 3709 26 with with IN cord-015306-us58wwmp 3709 27 renal renal JJ cord-015306-us58wwmp 3709 28 transplantation transplantation NN cord-015306-us58wwmp 3709 29 has have VBZ cord-015306-us58wwmp 3709 30 not not RB cord-015306-us58wwmp 3709 31 been be VBN cord-015306-us58wwmp 3709 32 well well RB cord-015306-us58wwmp 3709 33 established establish VBN cord-015306-us58wwmp 3709 34 . . . cord-015306-us58wwmp 3710 1 The the DT cord-015306-us58wwmp 3710 2 aim aim NN cord-015306-us58wwmp 3710 3 of of IN cord-015306-us58wwmp 3710 4 this this DT cord-015306-us58wwmp 3710 5 study study NN cord-015306-us58wwmp 3710 6 was be VBD cord-015306-us58wwmp 3710 7 to to TO cord-015306-us58wwmp 3710 8 evaluate evaluate VB cord-015306-us58wwmp 3710 9 the the DT cord-015306-us58wwmp 3710 10 influence influence NN cord-015306-us58wwmp 3710 11 of of IN cord-015306-us58wwmp 3710 12 non non JJ cord-015306-us58wwmp 3710 13 dipping dipping NN cord-015306-us58wwmp 3710 14 status status NN cord-015306-us58wwmp 3710 15 on on IN cord-015306-us58wwmp 3710 16 left left JJ cord-015306-us58wwmp 3710 17 ventricular ventricular JJ cord-015306-us58wwmp 3710 18 mass mass JJ cord-015306-us58wwmp 3710 19 index index NN cord-015306-us58wwmp 3710 20 and and CC cord-015306-us58wwmp 3710 21 diastolic diastolic JJ cord-015306-us58wwmp 3710 22 function function NN cord-015306-us58wwmp 3710 23 in in IN cord-015306-us58wwmp 3710 24 subjects subject NNS cord-015306-us58wwmp 3710 25 with with IN cord-015306-us58wwmp 3710 26 renal renal JJ cord-015306-us58wwmp 3710 27 transplantation transplantation NN cord-015306-us58wwmp 3710 28 . . . cord-015306-us58wwmp 3711 1 Methods method NNS cord-015306-us58wwmp 3711 2 : : : cord-015306-us58wwmp 3712 1 Sixty sixty CD cord-015306-us58wwmp 3712 2 six six CD cord-015306-us58wwmp 3712 3 stable stable JJ cord-015306-us58wwmp 3712 4 renal renal JJ cord-015306-us58wwmp 3712 5 transplant transplant NN cord-015306-us58wwmp 3712 6 patients patient NNS cord-015306-us58wwmp 3712 7 ( ( -LRB- cord-015306-us58wwmp 3712 8 34 34 CD cord-015306-us58wwmp 3712 9 females female NNS cord-015306-us58wwmp 3712 10 , , , cord-015306-us58wwmp 3712 11 32 32 CD cord-015306-us58wwmp 3712 12 males male NNS cord-015306-us58wwmp 3712 13 ) ) -RRB- cord-015306-us58wwmp 3712 14 , , , cord-015306-us58wwmp 3712 15 aged age VBN cord-015306-us58wwmp 3712 16 7 7 CD cord-015306-us58wwmp 3712 17 to to TO cord-015306-us58wwmp 3712 18 25 25 CD cord-015306-us58wwmp 3712 19 years year NNS cord-015306-us58wwmp 3712 20 ( ( -LRB- cord-015306-us58wwmp 3712 21 mean mean VB cord-015306-us58wwmp 3712 22 17.4±4.3 17.4±4.3 CD cord-015306-us58wwmp 3712 23 years year NNS cord-015306-us58wwmp 3712 24 ) ) -RRB- cord-015306-us58wwmp 3712 25 were be VBD cord-015306-us58wwmp 3712 26 enrolled enrol VBN cord-015306-us58wwmp 3712 27 in in IN cord-015306-us58wwmp 3712 28 this this DT cord-015306-us58wwmp 3712 29 study study NN cord-015306-us58wwmp 3712 30 . . . cord-015306-us58wwmp 3713 1 Cardiac cardiac JJ cord-015306-us58wwmp 3713 2 function function NN cord-015306-us58wwmp 3713 3 assessed assess VBN cord-015306-us58wwmp 3713 4 by by IN cord-015306-us58wwmp 3713 5 tissue tissue NN cord-015306-us58wwmp 3713 6 Doppler doppler NN cord-015306-us58wwmp 3713 7 echocardiography echocardiography NN cord-015306-us58wwmp 3713 8 and and CC cord-015306-us58wwmp 3713 9 blood blood NN cord-015306-us58wwmp 3713 10 pressure pressure NN cord-015306-us58wwmp 3713 11 measurement measurement NN cord-015306-us58wwmp 3713 12 performed perform VBN cord-015306-us58wwmp 3713 13 using use VBG cord-015306-us58wwmp 3713 14 ambulatory ambulatory JJ cord-015306-us58wwmp 3713 15 method method NN cord-015306-us58wwmp 3713 16 . . . cord-015306-us58wwmp 3714 1 Dipping dipping NN cord-015306-us58wwmp 3714 2 was be VBD cord-015306-us58wwmp 3714 3 defined define VBN cord-015306-us58wwmp 3714 4 as as IN cord-015306-us58wwmp 3714 5 at at RB cord-015306-us58wwmp 3714 6 least least RBS cord-015306-us58wwmp 3714 7 10 10 CD cord-015306-us58wwmp 3714 8 % % NN cord-015306-us58wwmp 3714 9 BP BP NNP cord-015306-us58wwmp 3714 10 decline decline NN cord-015306-us58wwmp 3714 11 during during IN cord-015306-us58wwmp 3714 12 the the DT cord-015306-us58wwmp 3714 13 night night NN cord-015306-us58wwmp 3714 14 and and CC cord-015306-us58wwmp 3714 15 was be VBD cord-015306-us58wwmp 3714 16 calculated calculate VBN cord-015306-us58wwmp 3714 17 as as IN cord-015306-us58wwmp 3714 18 ( ( -LRB- cord-015306-us58wwmp 3714 19 mean mean VB cord-015306-us58wwmp 3714 20 daytime daytime JJ cord-015306-us58wwmp 3714 21 -mean -mean CD cord-015306-us58wwmp 3714 22 night night NN cord-015306-us58wwmp 3714 23 time time NN cord-015306-us58wwmp 3714 24 / / , cord-015306-us58wwmp 3714 25 mean mean VBP cord-015306-us58wwmp 3714 26 daytime)*% daytime)*% NNP cord-015306-us58wwmp 3714 27 100 100 CD cord-015306-us58wwmp 3714 28 . . . cord-015306-us58wwmp 3715 1 Left leave VBN cord-015306-us58wwmp 3715 2 ventricular ventricular JJ cord-015306-us58wwmp 3715 3 mass mass NN cord-015306-us58wwmp 3715 4 ( ( -LRB- cord-015306-us58wwmp 3715 5 LVM LVM NNP cord-015306-us58wwmp 3715 6 ) ) -RRB- cord-015306-us58wwmp 3715 7 was be VBD cord-015306-us58wwmp 3715 8 calculated calculate VBN cord-015306-us58wwmp 3715 9 by by IN cord-015306-us58wwmp 3715 10 standard standard JJ cord-015306-us58wwmp 3715 11 2dimensional 2dimensional CD cord-015306-us58wwmp 3715 12 directed direct VBN cord-015306-us58wwmp 3715 13 M M NNP cord-015306-us58wwmp 3715 14 - - HYPH cord-015306-us58wwmp 3715 15 mode mode NN cord-015306-us58wwmp 3715 16 echocardiography echocardiography NN cord-015306-us58wwmp 3715 17 according accord VBG cord-015306-us58wwmp 3715 18 to to IN cord-015306-us58wwmp 3715 19 the the DT cord-015306-us58wwmp 3715 20 formula formula NN cord-015306-us58wwmp 3715 21 of of IN cord-015306-us58wwmp 3715 22 Devereux Devereux NNP cord-015306-us58wwmp 3715 23 and and CC cord-015306-us58wwmp 3715 24 was be VBD cord-015306-us58wwmp 3715 25 indexed index VBN cord-015306-us58wwmp 3715 26 to to TO cord-015306-us58wwmp 3715 27 height height VB cord-015306-us58wwmp 3715 28 in in IN cord-015306-us58wwmp 3715 29 meters meter NNS cord-015306-us58wwmp 3715 30 to to IN cord-015306-us58wwmp 3715 31 the the DT cord-015306-us58wwmp 3715 32 2.7 2.7 CD cord-015306-us58wwmp 3715 33 power power NN cord-015306-us58wwmp 3715 34 to to TO cord-015306-us58wwmp 3715 35 allow allow VB cord-015306-us58wwmp 3715 36 the the DT cord-015306-us58wwmp 3715 37 comparison comparison NN cord-015306-us58wwmp 3715 38 between between IN cord-015306-us58wwmp 3715 39 recipients recipient NNS cord-015306-us58wwmp 3715 40 of of IN cord-015306-us58wwmp 3715 41 different different JJ cord-015306-us58wwmp 3715 42 sizes size NNS cord-015306-us58wwmp 3715 43 . . . cord-015306-us58wwmp 3716 1 Left leave VBN cord-015306-us58wwmp 3716 2 ventricular ventricular JJ cord-015306-us58wwmp 3716 3 hypertrophy hypertrophy NN cord-015306-us58wwmp 3716 4 was be VBD cord-015306-us58wwmp 3716 5 defined define VBN cord-015306-us58wwmp 3716 6 as as IN cord-015306-us58wwmp 3716 7 LVMI>38.6g LVMI>38.6g NNP cord-015306-us58wwmp 3716 8 / / SYM cord-015306-us58wwmp 3716 9 m m NNP cord-015306-us58wwmp 3716 10 2.7 2.7 CD cord-015306-us58wwmp 3716 11 in in IN cord-015306-us58wwmp 3716 12 patients patient NNS cord-015306-us58wwmp 3716 13 younger young JJR cord-015306-us58wwmp 3716 14 than than IN cord-015306-us58wwmp 3716 15 18 18 CD cord-015306-us58wwmp 3716 16 years year NNS cord-015306-us58wwmp 3716 17 and and CC cord-015306-us58wwmp 3716 18 51 51 CD cord-015306-us58wwmp 3716 19 g g NN cord-015306-us58wwmp 3717 1 /m /m NNP cord-015306-us58wwmp 3717 2 2.7 2.7 CD cord-015306-us58wwmp 3717 3 in in IN cord-015306-us58wwmp 3717 4 patients patient NNS cord-015306-us58wwmp 3717 5 > > XX cord-015306-us58wwmp 3717 6 18 18 CD cord-015306-us58wwmp 3717 7 years year NNS cord-015306-us58wwmp 3717 8 . . . cord-015306-us58wwmp 3718 1 Data data NN cord-015306-us58wwmp 3718 2 analysis analysis NN cord-015306-us58wwmp 3718 3 was be VBD cord-015306-us58wwmp 3718 4 performed perform VBN cord-015306-us58wwmp 3718 5 by by IN cord-015306-us58wwmp 3718 6 SPSS-15 SPSS-15 NNPS cord-015306-us58wwmp 3718 7 . . . cord-015306-us58wwmp 3719 1 A a DT cord-015306-us58wwmp 3719 2 P<0.05 p<0.05 NN cord-015306-us58wwmp 3719 3 was be VBD cord-015306-us58wwmp 3719 4 considered consider VBN cord-015306-us58wwmp 3719 5 statistically statistically RB cord-015306-us58wwmp 3719 6 significant significant JJ cord-015306-us58wwmp 3719 7 . . . cord-015306-us58wwmp 3720 1 Results result NNS cord-015306-us58wwmp 3720 2 : : : cord-015306-us58wwmp 3721 1 Non non JJ cord-015306-us58wwmp 3721 2 - - JJ cord-015306-us58wwmp 3721 3 dipping dipping NN cord-015306-us58wwmp 3721 4 was be VBD cord-015306-us58wwmp 3721 5 identified identify VBN cord-015306-us58wwmp 3721 6 in in IN cord-015306-us58wwmp 3721 7 48 48 CD cord-015306-us58wwmp 3721 8 ( ( -LRB- cord-015306-us58wwmp 3721 9 73 73 CD cord-015306-us58wwmp 3721 10 % % NN cord-015306-us58wwmp 3721 11 ) ) -RRB- cord-015306-us58wwmp 3721 12 patients patient NNS cord-015306-us58wwmp 3721 13 . . . cord-015306-us58wwmp 3722 1 Five five CD cord-015306-us58wwmp 3722 2 recipients recipient NNS cord-015306-us58wwmp 3722 3 were be VBD cord-015306-us58wwmp 3722 4 systolic systolic JJ cord-015306-us58wwmp 3722 5 non non JJ cord-015306-us58wwmp 3722 6 - - NNS cord-015306-us58wwmp 3722 7 dippers dipper NNS cord-015306-us58wwmp 3722 8 , , , cord-015306-us58wwmp 3722 9 1 1 CD cord-015306-us58wwmp 3722 10 diastolic diastolic JJ cord-015306-us58wwmp 3722 11 non non JJ cord-015306-us58wwmp 3722 12 - - JJ cord-015306-us58wwmp 3722 13 dipper dipper JJ cord-015306-us58wwmp 3722 14 , , , cord-015306-us58wwmp 3722 15 and and CC cord-015306-us58wwmp 3722 16 42 42 CD cord-015306-us58wwmp 3722 17 both both CC cord-015306-us58wwmp 3722 18 systolic systolic JJ cord-015306-us58wwmp 3722 19 and and CC cord-015306-us58wwmp 3722 20 diastolic diastolic JJ cord-015306-us58wwmp 3722 21 non non JJ cord-015306-us58wwmp 3722 22 - - NNS cord-015306-us58wwmp 3722 23 dippers dipper NNS cord-015306-us58wwmp 3722 24 . . . cord-015306-us58wwmp 3723 1 Left leave VBN cord-015306-us58wwmp 3723 2 ventricular ventricular JJ cord-015306-us58wwmp 3723 3 hypertrophy hypertrophy NN cord-015306-us58wwmp 3723 4 ( ( -LRB- cord-015306-us58wwmp 3723 5 LVH LVH NNP cord-015306-us58wwmp 3723 6 ) ) -RRB- cord-015306-us58wwmp 3723 7 was be VBD cord-015306-us58wwmp 3723 8 found find VBN cord-015306-us58wwmp 3723 9 in in IN cord-015306-us58wwmp 3723 10 37.1 37.1 CD cord-015306-us58wwmp 3723 11 % % NN cord-015306-us58wwmp 3723 12 of of IN cord-015306-us58wwmp 3723 13 the the DT cord-015306-us58wwmp 3723 14 renal renal JJ cord-015306-us58wwmp 3723 15 allograft allograft NN cord-015306-us58wwmp 3723 16 recipients recipient NNS cord-015306-us58wwmp 3723 17 . . . cord-015306-us58wwmp 3724 1 LVH LVH NNP cord-015306-us58wwmp 3724 2 was be VBD cord-015306-us58wwmp 3724 3 present present JJ cord-015306-us58wwmp 3724 4 in in IN cord-015306-us58wwmp 3724 5 41 41 CD cord-015306-us58wwmp 3724 6 % % NN cord-015306-us58wwmp 3724 7 of of IN cord-015306-us58wwmp 3724 8 the the DT cord-015306-us58wwmp 3724 9 systolic systolic JJ cord-015306-us58wwmp 3724 10 nondippers nondipper NNS cord-015306-us58wwmp 3724 11 and and CC cord-015306-us58wwmp 3724 12 27.8 27.8 CD cord-015306-us58wwmp 3724 13 % % NN cord-015306-us58wwmp 3724 14 of of IN cord-015306-us58wwmp 3724 15 the the DT cord-015306-us58wwmp 3724 16 systolic systolic JJ cord-015306-us58wwmp 3724 17 dippers dipper NNS cord-015306-us58wwmp 3724 18 ( ( -LRB- cord-015306-us58wwmp 3724 19 p=0.33 p=0.33 NNP cord-015306-us58wwmp 3724 20 ) ) -RRB- cord-015306-us58wwmp 3724 21 . . . cord-015306-us58wwmp 3725 1 Forty forty CD cord-015306-us58wwmp 3725 2 five five CD cord-015306-us58wwmp 3725 3 percent percent NN cord-015306-us58wwmp 3725 4 of of IN cord-015306-us58wwmp 3725 5 the the DT cord-015306-us58wwmp 3725 6 diastolic diastolic JJ cord-015306-us58wwmp 3725 7 non non AFX cord-015306-us58wwmp 3725 8 dippers dipper NNS cord-015306-us58wwmp 3725 9 and and CC cord-015306-us58wwmp 3725 10 22.7 22.7 CD cord-015306-us58wwmp 3725 11 % % NN cord-015306-us58wwmp 3725 12 of of IN cord-015306-us58wwmp 3725 13 the the DT cord-015306-us58wwmp 3725 14 diastolic diastolic JJ cord-015306-us58wwmp 3725 15 dippers dipper NNS cord-015306-us58wwmp 3725 16 had have VBD cord-015306-us58wwmp 3725 17 LVH LVH NNP cord-015306-us58wwmp 3725 18 ( ( -LRB- cord-015306-us58wwmp 3725 19 p=0.08 p=0.08 NNP cord-015306-us58wwmp 3725 20 ) ) -RRB- cord-015306-us58wwmp 3725 21 . . . cord-015306-us58wwmp 3726 1 There there EX cord-015306-us58wwmp 3726 2 was be VBD cord-015306-us58wwmp 3726 3 no no DT cord-015306-us58wwmp 3726 4 correlation correlation NN cord-015306-us58wwmp 3726 5 between between IN cord-015306-us58wwmp 3726 6 systolic systolic JJ cord-015306-us58wwmp 3726 7 and and CC cord-015306-us58wwmp 3726 8 diastolic diastolic JJ cord-015306-us58wwmp 3726 9 dipping dipping NN cord-015306-us58wwmp 3726 10 status status NN cord-015306-us58wwmp 3726 11 and and CC cord-015306-us58wwmp 3726 12 LVH LVH NNP cord-015306-us58wwmp 3726 13 , , , cord-015306-us58wwmp 3726 14 respectively respectively RB cord-015306-us58wwmp 3726 15 ( ( -LRB- cord-015306-us58wwmp 3726 16 p=0.33 p=0.33 NNP cord-015306-us58wwmp 3726 17 , , , cord-015306-us58wwmp 3726 18 p= p= NNP cord-015306-us58wwmp 3726 19 0.08 0.08 CD cord-015306-us58wwmp 3726 20 ) ) -RRB- cord-015306-us58wwmp 3726 21 . . . cord-015306-us58wwmp 3727 1 There there EX cord-015306-us58wwmp 3727 2 were be VBD cord-015306-us58wwmp 3727 3 no no DT cord-015306-us58wwmp 3727 4 significant significant JJ cord-015306-us58wwmp 3727 5 differences difference NNS cord-015306-us58wwmp 3727 6 in in IN cord-015306-us58wwmp 3727 7 terms term NNS cord-015306-us58wwmp 3727 8 of of IN cord-015306-us58wwmp 3727 9 diastolic diastolic JJ cord-015306-us58wwmp 3727 10 function function NN cord-015306-us58wwmp 3727 11 [ [ -LRB- cord-015306-us58wwmp 3727 12 measured measure VBN cord-015306-us58wwmp 3727 13 by by IN cord-015306-us58wwmp 3727 14 Early early JJ cord-015306-us58wwmp 3727 15 diastolic diastolic JJ cord-015306-us58wwmp 3727 16 inflow inflow NN cord-015306-us58wwmp 3727 17 velocity velocity NN cord-015306-us58wwmp 3727 18 ( ( -LRB- cord-015306-us58wwmp 3727 19 E E NNP cord-015306-us58wwmp 3727 20 ) ) -RRB- cord-015306-us58wwmp 3727 21 , , , cord-015306-us58wwmp 3727 22 E E NNP cord-015306-us58wwmp 3727 23 / / SYM cord-015306-us58wwmp 3727 24 A a DT cord-015306-us58wwmp 3727 25 ratio ratio NN cord-015306-us58wwmp 3727 26 , , , cord-015306-us58wwmp 3727 27 and and CC cord-015306-us58wwmp 3727 28 early early JJ cord-015306-us58wwmp 3727 29 diastolic diastolic JJ cord-015306-us58wwmp 3727 30 mitral mitral JJ cord-015306-us58wwmp 3727 31 inflow inflow JJ cord-015306-us58wwmp 3727 32 velocity velocity NN cord-015306-us58wwmp 3727 33 to to IN cord-015306-us58wwmp 3727 34 earlydiastolic earlydiastolic JJ cord-015306-us58wwmp 3727 35 annular annular JJ cord-015306-us58wwmp 3727 36 velocity velocity NN cord-015306-us58wwmp 3728 1 ( ( -LRB- cord-015306-us58wwmp 3728 2 E E NNP cord-015306-us58wwmp 3728 3 / / SYM cord-015306-us58wwmp 3728 4 Ea Ea NNP cord-015306-us58wwmp 3728 5 ) ) -RRB- cord-015306-us58wwmp 3728 6 ] ] -RRB- cord-015306-us58wwmp 3729 1 between between IN cord-015306-us58wwmp 3729 2 dipper dipper NN cord-015306-us58wwmp 3729 3 and and CC cord-015306-us58wwmp 3729 4 non non NNP cord-015306-us58wwmp 3729 5 dippergroups(p= dippergroups(p= NNP cord-015306-us58wwmp 3729 6 > > SYM cord-015306-us58wwmp 3729 7 0.05 0.05 CD cord-015306-us58wwmp 3729 8 ) ) -RRB- cord-015306-us58wwmp 3730 1 . . . cord-015306-us58wwmp 3731 1 Conclusion conclusion NN cord-015306-us58wwmp 3731 2 : : : cord-015306-us58wwmp 3732 1 Non non JJ cord-015306-us58wwmp 3732 2 dipping dipping NN cord-015306-us58wwmp 3732 3 is be VBZ cord-015306-us58wwmp 3732 4 common common JJ cord-015306-us58wwmp 3732 5 among among IN cord-015306-us58wwmp 3732 6 renal renal JJ cord-015306-us58wwmp 3732 7 transplant transplant NN cord-015306-us58wwmp 3732 8 recipients recipient NNS cord-015306-us58wwmp 3732 9 , , , cord-015306-us58wwmp 3732 10 but but CC cord-015306-us58wwmp 3732 11 is be VBZ cord-015306-us58wwmp 3732 12 not not RB cord-015306-us58wwmp 3732 13 always always RB cord-015306-us58wwmp 3732 14 related relate VBN cord-015306-us58wwmp 3732 15 to to IN cord-015306-us58wwmp 3732 16 diastolic diastolic JJ cord-015306-us58wwmp 3732 17 dysfunction dysfunction NN cord-015306-us58wwmp 3732 18 and and CC cord-015306-us58wwmp 3732 19 LVH LVH NNP cord-015306-us58wwmp 3732 20 . . . cord-015306-us58wwmp 3733 1 Prospective prospective JJ cord-015306-us58wwmp 3733 2 longitudinal longitudinal JJ cord-015306-us58wwmp 3733 3 studies study NNS cord-015306-us58wwmp 3733 4 are be VBP cord-015306-us58wwmp 3733 5 required require VBN cord-015306-us58wwmp 3733 6 to to TO cord-015306-us58wwmp 3733 7 determine determine VB cord-015306-us58wwmp 3733 8 the the DT cord-015306-us58wwmp 3733 9 impact impact NN cord-015306-us58wwmp 3733 10 of of IN cord-015306-us58wwmp 3733 11 dipping dip VBG cord-015306-us58wwmp 3733 12 status status NN cord-015306-us58wwmp 3733 13 on on IN cord-015306-us58wwmp 3733 14 diastolic diastolic JJ cord-015306-us58wwmp 3733 15 and and CC cord-015306-us58wwmp 3733 16 structural structural JJ cord-015306-us58wwmp 3733 17 heart heart NN cord-015306-us58wwmp 3733 18 function function NN cord-015306-us58wwmp 3733 19 in in IN cord-015306-us58wwmp 3733 20 renal renal JJ cord-015306-us58wwmp 3733 21 transplant transplant NN cord-015306-us58wwmp 3733 22 recipients recipient NNS cord-015306-us58wwmp 3733 23 . . . cord-015306-us58wwmp 3734 1 Parsa Parsa NNP cord-015306-us58wwmp 3734 2 Yousefi Yousefi NNP cord-015306-us58wwmp 3734 3 Chaijan Chaijan NNP cord-015306-us58wwmp 3734 4 , , , cord-015306-us58wwmp 3734 5 Parvin Parvin NNP cord-015306-us58wwmp 3734 6 Soltani Soltani NNP cord-015306-us58wwmp 3734 7 , , , cord-015306-us58wwmp 3734 8 Farshid Farshid NNP cord-015306-us58wwmp 3734 9 Haghverdi Haghverdi NNPS cord-015306-us58wwmp 3734 10 , , , cord-015306-us58wwmp 3734 11 Masood Masood NNP cord-015306-us58wwmp 3734 12 FazeliMoslehabadee FazeliMoslehabadee NNP cord-015306-us58wwmp 3734 13 Nephrology Nephrology NNP cord-015306-us58wwmp 3734 14 , , , cord-015306-us58wwmp 3734 15 Arak Arak NNP cord-015306-us58wwmp 3734 16 University University NNP cord-015306-us58wwmp 3734 17 of of IN cord-015306-us58wwmp 3734 18 medical medical JJ cord-015306-us58wwmp 3734 19 sciences science NNS cord-015306-us58wwmp 3734 20 , , , cord-015306-us58wwmp 3734 21 Arak Arak NNP cord-015306-us58wwmp 3734 22 , , , cord-015306-us58wwmp 3735 1 Iran Iran NNP cord-015306-us58wwmp 3735 2 Objective Objective NNP cord-015306-us58wwmp 3735 3 : : : cord-015306-us58wwmp 3736 1 Nephrolithiasis nephrolithiasis NN cord-015306-us58wwmp 3736 2 in in IN cord-015306-us58wwmp 3736 3 renal renal JJ cord-015306-us58wwmp 3736 4 grafts graft NNS cord-015306-us58wwmp 3736 5 is be VBZ cord-015306-us58wwmp 3736 6 a a DT cord-015306-us58wwmp 3736 7 relatively relatively RB cord-015306-us58wwmp 3736 8 common common JJ cord-015306-us58wwmp 3736 9 phenomenon phenomenon NN cord-015306-us58wwmp 3736 10 which which WDT cord-015306-us58wwmp 3736 11 can can MD cord-015306-us58wwmp 3736 12 induce induce VB cord-015306-us58wwmp 3736 13 organ organ NN cord-015306-us58wwmp 3736 14 damage damage NN cord-015306-us58wwmp 3736 15 ; ; : cord-015306-us58wwmp 3736 16 hence hence RB cord-015306-us58wwmp 3736 17 early early JJ cord-015306-us58wwmp 3736 18 diagnosis diagnosis NN cord-015306-us58wwmp 3736 19 and and CC cord-015306-us58wwmp 3736 20 management management NN cord-015306-us58wwmp 3736 21 of of IN cord-015306-us58wwmp 3736 22 predisposing predisposing JJ cord-015306-us58wwmp 3736 23 factors factor NNS cord-015306-us58wwmp 3736 24 can can MD cord-015306-us58wwmp 3736 25 preclude preclude VB cord-015306-us58wwmp 3736 26 subsequent subsequent JJ cord-015306-us58wwmp 3736 27 complications complication NNS cord-015306-us58wwmp 3736 28 . . . cord-015306-us58wwmp 3737 1 The the DT cord-015306-us58wwmp 3737 2 aim aim NN cord-015306-us58wwmp 3737 3 of of IN cord-015306-us58wwmp 3737 4 this this DT cord-015306-us58wwmp 3737 5 analytic analytic JJ cord-015306-us58wwmp 3737 6 cross cross JJ cord-015306-us58wwmp 3737 7 - - JJ cord-015306-us58wwmp 3737 8 sectional sectional JJ cord-015306-us58wwmp 3737 9 study study NN cord-015306-us58wwmp 3737 10 is be VBZ cord-015306-us58wwmp 3737 11 to to TO cord-015306-us58wwmp 3737 12 determine determine VB cord-015306-us58wwmp 3737 13 the the DT cord-015306-us58wwmp 3737 14 contributory contributory JJ cord-015306-us58wwmp 3737 15 factors factor NNS cord-015306-us58wwmp 3737 16 to to IN cord-015306-us58wwmp 3737 17 nephrolithiasis nephrolithiasis NN cord-015306-us58wwmp 3737 18 after after IN cord-015306-us58wwmp 3737 19 renal renal JJ cord-015306-us58wwmp 3737 20 transplantation transplantation NN cord-015306-us58wwmp 3737 21 . . . cord-015306-us58wwmp 3738 1 Method method NN cord-015306-us58wwmp 3738 2 : : : cord-015306-us58wwmp 3738 3 56 56 CD cord-015306-us58wwmp 3738 4 renal renal JJ cord-015306-us58wwmp 3738 5 - - HYPH cord-015306-us58wwmp 3738 6 transplanted transplant VBN cord-015306-us58wwmp 3738 7 patients patient NNS cord-015306-us58wwmp 3738 8 ( ( -LRB- cord-015306-us58wwmp 3738 9 10 10 CD cord-015306-us58wwmp 3738 10 - - SYM cord-015306-us58wwmp 3738 11 40 40 CD cord-015306-us58wwmp 3738 12 years year NNS cord-015306-us58wwmp 3738 13 old old JJ cord-015306-us58wwmp 3738 14 ) ) -RRB- cord-015306-us58wwmp 3738 15 were be VBD cord-015306-us58wwmp 3738 16 enrolled enrol VBN cord-015306-us58wwmp 3738 17 in in IN cord-015306-us58wwmp 3738 18 the the DT cord-015306-us58wwmp 3738 19 study study NN cord-015306-us58wwmp 3738 20 , , , cord-015306-us58wwmp 3738 21 being be VBG cord-015306-us58wwmp 3738 22 divided divide VBN cord-015306-us58wwmp 3738 23 into into IN cord-015306-us58wwmp 3738 24 two two CD cord-015306-us58wwmp 3738 25 groups group NNS cord-015306-us58wwmp 3738 26 of of IN cord-015306-us58wwmp 3738 27 28 28 CD cord-015306-us58wwmp 3738 28 transplanted transplant VBN cord-015306-us58wwmp 3738 29 patients patient NNS cord-015306-us58wwmp 3738 30 suffering suffer VBG cord-015306-us58wwmp 3738 31 from from IN cord-015306-us58wwmp 3738 32 nephrolithiasis nephrolithiasis NNP cord-015306-us58wwmp 3738 33 ( ( -LRB- cord-015306-us58wwmp 3738 34 within within IN cord-015306-us58wwmp 3738 35 first first JJ cord-015306-us58wwmp 3738 36 5 5 CD cord-015306-us58wwmp 3738 37 years year NNS cord-015306-us58wwmp 3738 38 after after IN cord-015306-us58wwmp 3738 39 surgery surgery NN cord-015306-us58wwmp 3738 40 ) ) -RRB- cord-015306-us58wwmp 3738 41 and and CC cord-015306-us58wwmp 3738 42 28 28 CD cord-015306-us58wwmp 3738 43 transplanted transplant VBN cord-015306-us58wwmp 3738 44 patients patient NNS cord-015306-us58wwmp 3738 45 free free JJ cord-015306-us58wwmp 3738 46 from from IN cord-015306-us58wwmp 3738 47 renal renal JJ cord-015306-us58wwmp 3738 48 stone stone NN cord-015306-us58wwmp 3738 49 with with IN cord-015306-us58wwmp 3738 50 the the DT cord-015306-us58wwmp 3738 51 same same JJ cord-015306-us58wwmp 3738 52 age age NN cord-015306-us58wwmp 3738 53 and and CC cord-015306-us58wwmp 3738 54 gender gender NN cord-015306-us58wwmp 3738 55 and and CC cord-015306-us58wwmp 3738 56 similar similar JJ cord-015306-us58wwmp 3738 57 GFR GFR NNP cord-015306-us58wwmp 3738 58 . . . cord-015306-us58wwmp 3739 1 Data datum NNS cord-015306-us58wwmp 3739 2 were be VBD cord-015306-us58wwmp 3739 3 collected collect VBN cord-015306-us58wwmp 3739 4 and and CC cord-015306-us58wwmp 3739 5 arranged arrange VBN cord-015306-us58wwmp 3739 6 in in IN cord-015306-us58wwmp 3739 7 Excellmicrosoft Excellmicrosoft NNP cord-015306-us58wwmp 3739 8 program program NN cord-015306-us58wwmp 3739 9 and and CC cord-015306-us58wwmp 3739 10 the the DT cord-015306-us58wwmp 3739 11 statistic statistic NN cord-015306-us58wwmp 3739 12 analysis analysis NN cord-015306-us58wwmp 3739 13 was be VBD cord-015306-us58wwmp 3739 14 carried carry VBN cord-015306-us58wwmp 3739 15 by by IN cord-015306-us58wwmp 3739 16 SPSS SPSS NNP cord-015306-us58wwmp 3739 17 V17 V17 NNP cord-015306-us58wwmp 3739 18 . . . cord-015306-us58wwmp 3740 1 Pvalue Pvalue NNP cord-015306-us58wwmp 3740 2 < < XX cord-015306-us58wwmp 3740 3 0.05 0.05 CD cord-015306-us58wwmp 3740 4 were be VBD cord-015306-us58wwmp 3740 5 considered consider VBN cord-015306-us58wwmp 3740 6 statistically statistically RB cord-015306-us58wwmp 3740 7 significant significant JJ cord-015306-us58wwmp 3740 8 . . . cord-015306-us58wwmp 3741 1 Result result NN cord-015306-us58wwmp 3741 2 : : : cord-015306-us58wwmp 3742 1 The the DT cord-015306-us58wwmp 3742 2 studied study VBN cord-015306-us58wwmp 3742 3 showed show VBD cord-015306-us58wwmp 3742 4 that that IN cord-015306-us58wwmp 3742 5 male male JJ cord-015306-us58wwmp 3742 6 gender gender NN cord-015306-us58wwmp 3742 7 ( ( -LRB- cord-015306-us58wwmp 3742 8 P p NN cord-015306-us58wwmp 3742 9 = = SYM cord-015306-us58wwmp 3742 10 0.048 0.048 CD cord-015306-us58wwmp 3742 11 ) ) -RRB- cord-015306-us58wwmp 3742 12 , , , cord-015306-us58wwmp 3742 13 age age NN cord-015306-us58wwmp 3742 14 group group NN cord-015306-us58wwmp 3742 15 of of IN cord-015306-us58wwmp 3742 16 15 15 CD cord-015306-us58wwmp 3742 17 - - SYM cord-015306-us58wwmp 3742 18 25 25 CD cord-015306-us58wwmp 3742 19 years year NNS cord-015306-us58wwmp 3742 20 ( ( -LRB- cord-015306-us58wwmp 3742 21 P=0.021 P=0.021 NNP cord-015306-us58wwmp 3742 22 ) ) -RRB- cord-015306-us58wwmp 3742 23 , , , cord-015306-us58wwmp 3742 24 hyper hyper NNP cord-015306-us58wwmp 3742 25 cholesterolemia cholesterolemia NNP cord-015306-us58wwmp 3742 26 ( ( -LRB- cord-015306-us58wwmp 3742 27 P=0.007 P=0.007 NNP cord-015306-us58wwmp 3742 28 ) ) -RRB- cord-015306-us58wwmp 3742 29 , , , cord-015306-us58wwmp 3742 30 hyper hyper JJ cord-015306-us58wwmp 3742 31 triglyceridemia triglyceridemia NN cord-015306-us58wwmp 3742 32 ( ( -LRB- cord-015306-us58wwmp 3742 33 P=0.031 P=0.031 NNP cord-015306-us58wwmp 3742 34 ) ) -RRB- cord-015306-us58wwmp 3742 35 , , , cord-015306-us58wwmp 3742 36 3 3 CD cord-015306-us58wwmp 3742 37 rd rd NN cord-015306-us58wwmp 3742 38 year year NN cord-015306-us58wwmp 3742 39 after after IN cord-015306-us58wwmp 3742 40 surgery surgery NN cord-015306-us58wwmp 3742 41 ( ( -LRB- cord-015306-us58wwmp 3742 42 P=0.023 P=0.023 NNP cord-015306-us58wwmp 3742 43 ) ) -RRB- cord-015306-us58wwmp 3742 44 , , , cord-015306-us58wwmp 3742 45 hyperuricosuria hyperuricosuria NNP cord-015306-us58wwmp 3742 46 ( ( -LRB- cord-015306-us58wwmp 3742 47 P=0.012 P=0.012 NNP cord-015306-us58wwmp 3742 48 ) ) -RRB- cord-015306-us58wwmp 3742 49 , , , cord-015306-us58wwmp 3742 50 hypocitraturia hypocitraturia NNP cord-015306-us58wwmp 3742 51 ( ( -LRB- cord-015306-us58wwmp 3742 52 P=0.001 P=0.001 NNP cord-015306-us58wwmp 3742 53 ) ) -RRB- cord-015306-us58wwmp 3742 54 and and CC cord-015306-us58wwmp 3742 55 Anemia anemia NN cord-015306-us58wwmp 3742 56 ( ( -LRB- cord-015306-us58wwmp 3742 57 P=0.006 P=0.006 NNP cord-015306-us58wwmp 3742 58 ) ) -RRB- cord-015306-us58wwmp 3742 59 were be VBD cord-015306-us58wwmp 3742 60 significantly significantly RB cord-015306-us58wwmp 3742 61 more more RBR cord-015306-us58wwmp 3742 62 common common JJ cord-015306-us58wwmp 3742 63 in in IN cord-015306-us58wwmp 3742 64 patients patient NNS cord-015306-us58wwmp 3742 65 with with IN cord-015306-us58wwmp 3742 66 nephrolithiasis nephrolithiasis NN cord-015306-us58wwmp 3742 67 . . . cord-015306-us58wwmp 3743 1 Conclusion conclusion NN cord-015306-us58wwmp 3743 2 : : : cord-015306-us58wwmp 3743 3 It -PRON- PRP cord-015306-us58wwmp 3743 4 is be VBZ cord-015306-us58wwmp 3743 5 better well JJR cord-015306-us58wwmp 3743 6 to to TO cord-015306-us58wwmp 3743 7 evaluate evaluate VB cord-015306-us58wwmp 3743 8 hyperuricosuria hyperuricosuria NNP cord-015306-us58wwmp 3743 9 and and CC cord-015306-us58wwmp 3743 10 hypocitraturia hypocitraturia NNP cord-015306-us58wwmp 3743 11 in in IN cord-015306-us58wwmp 3743 12 kidney kidney NN cord-015306-us58wwmp 3743 13 donors donor NNS cord-015306-us58wwmp 3743 14 , , , cord-015306-us58wwmp 3743 15 moreover moreover RB cord-015306-us58wwmp 3743 16 all all DT cord-015306-us58wwmp 3743 17 patients patient NNS cord-015306-us58wwmp 3743 18 had have VBD cord-015306-us58wwmp 3743 19 better well JJR cord-015306-us58wwmp 3743 20 undergo undergo JJ cord-015306-us58wwmp 3743 21 serial serial JJ cord-015306-us58wwmp 3743 22 sonography sonography NN cord-015306-us58wwmp 3743 23 for for IN cord-015306-us58wwmp 3743 24 early early JJ cord-015306-us58wwmp 3743 25 screen screen NN cord-015306-us58wwmp 3743 26 and and CC cord-015306-us58wwmp 3743 27 management management NN cord-015306-us58wwmp 3743 28 of of IN cord-015306-us58wwmp 3743 29 renal renal JJ cord-015306-us58wwmp 3743 30 stone stone NN cord-015306-us58wwmp 3743 31 as as RB cord-015306-us58wwmp 3743 32 well well RB cord-015306-us58wwmp 3743 33 as as IN cord-015306-us58wwmp 3743 34 treatment treatment NN cord-015306-us58wwmp 3743 35 for for IN cord-015306-us58wwmp 3743 36 hyperlipidemia hyperlipidemia NN cord-015306-us58wwmp 3743 37 and and CC cord-015306-us58wwmp 3743 38 anemia anemia NN cord-015306-us58wwmp 3743 39 . . . cord-015306-us58wwmp 3744 1 It -PRON- PRP cord-015306-us58wwmp 3744 2 also also RB cord-015306-us58wwmp 3744 3 seems seem VBZ cord-015306-us58wwmp 3744 4 prudent prudent JJ cord-015306-us58wwmp 3744 5 to to TO cord-015306-us58wwmp 3744 6 further further RB cord-015306-us58wwmp 3744 7 assess assess VB cord-015306-us58wwmp 3744 8 the the DT cord-015306-us58wwmp 3744 9 donors donor NNS cord-015306-us58wwmp 3744 10 of of IN cord-015306-us58wwmp 3744 11 transplanted transplanted JJ cord-015306-us58wwmp 3744 12 patients patient NNS cord-015306-us58wwmp 3744 13 suffering suffer VBG cord-015306-us58wwmp 3744 14 from from IN cord-015306-us58wwmp 3744 15 renal renal JJ cord-015306-us58wwmp 3744 16 stone stone NN cord-015306-us58wwmp 3744 17 and and CC cord-015306-us58wwmp 3744 18 possbile possbile JJ cord-015306-us58wwmp 3744 19 relation relation NN cord-015306-us58wwmp 3744 20 between between IN cord-015306-us58wwmp 3744 21 CNI CNI NNP cord-015306-us58wwmp 3744 22 & & CC cord-015306-us58wwmp 3744 23 nephrolithiasis nephrolithiasis NNP cord-015306-us58wwmp 3744 24 ( ( -LRB- cord-015306-us58wwmp 3744 25 regardinghyperuricusuria regardinghyperuricusuria NNP cord-015306-us58wwmp 3744 26 ) ) -RRB- cord-015306-us58wwmp 3745 1 Objective objective JJ cord-015306-us58wwmp 3745 2 : : : cord-015306-us58wwmp 3745 3 Epstein Epstein NNP cord-015306-us58wwmp 3745 4 - - HYPH cord-015306-us58wwmp 3745 5 Barr Barr NNP cord-015306-us58wwmp 3745 6 virus virus NN cord-015306-us58wwmp 3745 7 - - HYPH cord-015306-us58wwmp 3745 8 associated associate VBN cord-015306-us58wwmp 3745 9 smooth smooth JJ cord-015306-us58wwmp 3745 10 muscle muscle NN cord-015306-us58wwmp 3745 11 tumor tumor NN cord-015306-us58wwmp 3745 12 ( ( -LRB- cord-015306-us58wwmp 3745 13 EBV EBV NNP cord-015306-us58wwmp 3745 14 - - HYPH cord-015306-us58wwmp 3745 15 SMT SMT NNP cord-015306-us58wwmp 3745 16 ) ) -RRB- cord-015306-us58wwmp 3745 17 in in IN cord-015306-us58wwmp 3745 18 immuno immuno JJ cord-015306-us58wwmp 3745 19 - - HYPH cord-015306-us58wwmp 3745 20 compromised compromise VBN cord-015306-us58wwmp 3745 21 patients patient NNS cord-015306-us58wwmp 3745 22 has have VBZ cord-015306-us58wwmp 3745 23 recently recently RB cord-015306-us58wwmp 3745 24 been be VBN cord-015306-us58wwmp 3745 25 reported report VBN cord-015306-us58wwmp 3745 26 . . . cord-015306-us58wwmp 3746 1 But but CC cord-015306-us58wwmp 3746 2 there there EX cord-015306-us58wwmp 3746 3 were be VBD cord-015306-us58wwmp 3746 4 no no DT cord-015306-us58wwmp 3746 5 evidence evidence NN cord-015306-us58wwmp 3746 6 about about IN cord-015306-us58wwmp 3746 7 the the DT cord-015306-us58wwmp 3746 8 treatment treatment NN cord-015306-us58wwmp 3746 9 of of IN cord-015306-us58wwmp 3746 10 EBV EBV NNP cord-015306-us58wwmp 3746 11 - - HYPH cord-015306-us58wwmp 3746 12 SMT SMT NNP cord-015306-us58wwmp 3746 13 . . . cord-015306-us58wwmp 3747 1 We -PRON- PRP cord-015306-us58wwmp 3747 2 report report VBP cord-015306-us58wwmp 3747 3 a a DT cord-015306-us58wwmp 3747 4 6-year 6-year JJ cord-015306-us58wwmp 3747 5 - - HYPH cord-015306-us58wwmp 3747 6 old old JJ cord-015306-us58wwmp 3747 7 girl girl NN cord-015306-us58wwmp 3747 8 treated treat VBN cord-015306-us58wwmp 3747 9 for for IN cord-015306-us58wwmp 3747 10 multiple multiple JJ cord-015306-us58wwmp 3747 11 EBV EBV NNP cord-015306-us58wwmp 3747 12 - - HYPH cord-015306-us58wwmp 3747 13 SMT SMT NNP cord-015306-us58wwmp 3747 14 by by IN cord-015306-us58wwmp 3747 15 using use VBG cord-015306-us58wwmp 3747 16 rituximab rituximab NN cord-015306-us58wwmp 3747 17 . . . cord-015306-us58wwmp 3748 1 Methods method NNS cord-015306-us58wwmp 3748 2 : : : cord-015306-us58wwmp 3749 1 Case case NN cord-015306-us58wwmp 3749 2 report report NN cord-015306-us58wwmp 3749 3 Results result NNS cord-015306-us58wwmp 3750 1 : : : cord-015306-us58wwmp 3750 2 She -PRON- PRP cord-015306-us58wwmp 3750 3 was be VBD cord-015306-us58wwmp 3750 4 suffering suffer VBG cord-015306-us58wwmp 3750 5 from from IN cord-015306-us58wwmp 3750 6 end end NN cord-015306-us58wwmp 3750 7 stage stage NN cord-015306-us58wwmp 3750 8 renal renal JJ cord-015306-us58wwmp 3750 9 disease disease NN cord-015306-us58wwmp 3750 10 due due JJ cord-015306-us58wwmp 3750 11 to to IN cord-015306-us58wwmp 3750 12 congenital congenital JJ cord-015306-us58wwmp 3750 13 nephrotic nephrotic JJ cord-015306-us58wwmp 3750 14 syndrome syndrome NN cord-015306-us58wwmp 3750 15 induced induce VBN cord-015306-us58wwmp 3750 16 by by IN cord-015306-us58wwmp 3750 17 WT1 WT1 NNP cord-015306-us58wwmp 3750 18 mutation mutation NN cord-015306-us58wwmp 3750 19 . . . cord-015306-us58wwmp 3751 1 Renal renal JJ cord-015306-us58wwmp 3751 2 transplantation transplantation NN cord-015306-us58wwmp 3751 3 ( ( -LRB- cord-015306-us58wwmp 3751 4 TX TX NNP cord-015306-us58wwmp 3751 5 ) ) -RRB- cord-015306-us58wwmp 3751 6 was be VBD cord-015306-us58wwmp 3751 7 performed perform VBN cord-015306-us58wwmp 3751 8 at at IN cord-015306-us58wwmp 3751 9 the the DT cord-015306-us58wwmp 3751 10 age age NN cord-015306-us58wwmp 3751 11 of of IN cord-015306-us58wwmp 3751 12 2 2 CD cord-015306-us58wwmp 3751 13 years year NNS cord-015306-us58wwmp 3751 14 , , , cord-015306-us58wwmp 3751 15 and and CC cord-015306-us58wwmp 3751 16 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 3751 17 therapy therapy NN cord-015306-us58wwmp 3751 18 was be VBD cord-015306-us58wwmp 3751 19 performed perform VBN cord-015306-us58wwmp 3751 20 her -PRON- PRP cord-015306-us58wwmp 3751 21 . . . cord-015306-us58wwmp 3752 1 Soon soon RB cord-015306-us58wwmp 3752 2 after after IN cord-015306-us58wwmp 3752 3 performing perform VBG cord-015306-us58wwmp 3752 4 TX TX NNP cord-015306-us58wwmp 3752 5 , , , cord-015306-us58wwmp 3752 6 she -PRON- PRP cord-015306-us58wwmp 3752 7 was be VBD cord-015306-us58wwmp 3752 8 infected infect VBN cord-015306-us58wwmp 3752 9 cytomegalovirus(CMV cytomegalovirus(CMV NNP cord-015306-us58wwmp 3752 10 ) ) -RRB- cord-015306-us58wwmp 3752 11 , , , cord-015306-us58wwmp 3752 12 BKV BKV NNP cord-015306-us58wwmp 3752 13 and and CC cord-015306-us58wwmp 3752 14 EBV EBV NNP cord-015306-us58wwmp 3752 15 . . . cord-015306-us58wwmp 3753 1 She -PRON- PRP cord-015306-us58wwmp 3753 2 was be VBD cord-015306-us58wwmp 3753 3 reduced reduce VBN cord-015306-us58wwmp 3753 4 in in IN cord-015306-us58wwmp 3753 5 amount amount NN cord-015306-us58wwmp 3753 6 of of IN cord-015306-us58wwmp 3753 7 immunosuppresive immunosuppresive JJ cord-015306-us58wwmp 3753 8 therapy therapy NN cord-015306-us58wwmp 3753 9 , , , cord-015306-us58wwmp 3753 10 and and CC cord-015306-us58wwmp 3753 11 she -PRON- PRP cord-015306-us58wwmp 3753 12 recovered recover VBD cord-015306-us58wwmp 3753 13 from from IN cord-015306-us58wwmp 3753 14 viremia viremia NN cord-015306-us58wwmp 3753 15 of of IN cord-015306-us58wwmp 3753 16 CMV CMV NNP cord-015306-us58wwmp 3753 17 and and CC cord-015306-us58wwmp 3753 18 BKV BKV NNP cord-015306-us58wwmp 3753 19 . . . cord-015306-us58wwmp 3754 1 Her -PRON- PRP$ cord-015306-us58wwmp 3754 2 EBV EBV NNP cord-015306-us58wwmp 3754 3 titer titer NN cord-015306-us58wwmp 3754 4 did do VBD cord-015306-us58wwmp 3754 5 not not RB cord-015306-us58wwmp 3754 6 become become VB cord-015306-us58wwmp 3754 7 negative negative JJ cord-015306-us58wwmp 3754 8 , , , cord-015306-us58wwmp 3754 9 but but CC cord-015306-us58wwmp 3754 10 we -PRON- PRP cord-015306-us58wwmp 3754 11 did do VBD cord-015306-us58wwmp 3754 12 not not RB cord-015306-us58wwmp 3754 13 perform perform VB cord-015306-us58wwmp 3754 14 any any DT cord-015306-us58wwmp 3754 15 medication medication NN cord-015306-us58wwmp 3754 16 because because IN cord-015306-us58wwmp 3754 17 of of IN cord-015306-us58wwmp 3754 18 no no DT cord-015306-us58wwmp 3754 19 symptom symptom NN cord-015306-us58wwmp 3754 20 . . . cord-015306-us58wwmp 3755 1 Four four CD cord-015306-us58wwmp 3755 2 years year NNS cord-015306-us58wwmp 3755 3 after after IN cord-015306-us58wwmp 3755 4 TX TX NNP cord-015306-us58wwmp 3755 5 , , , cord-015306-us58wwmp 3755 6 she -PRON- PRP cord-015306-us58wwmp 3755 7 was be VBD cord-015306-us58wwmp 3755 8 pointed point VBN cord-015306-us58wwmp 3755 9 out out RP cord-015306-us58wwmp 3755 10 1 1 CD cord-015306-us58wwmp 3755 11 cm cm NNS cord-015306-us58wwmp 3755 12 of of IN cord-015306-us58wwmp 3755 13 cholecystic cholecystic JJ cord-015306-us58wwmp 3755 14 polyp polyp NN cord-015306-us58wwmp 3755 15 in in IN cord-015306-us58wwmp 3755 16 a a DT cord-015306-us58wwmp 3755 17 protocol protocol NN cord-015306-us58wwmp 3755 18 abdomen abdomen NN cord-015306-us58wwmp 3755 19 ultrasonic ultrasonic JJ cord-015306-us58wwmp 3755 20 examination examination NN cord-015306-us58wwmp 3755 21 . . . cord-015306-us58wwmp 3756 1 We -PRON- PRP cord-015306-us58wwmp 3756 2 soon soon RB cord-015306-us58wwmp 3756 3 performed perform VBD cord-015306-us58wwmp 3756 4 cholecystectomy cholecystectomy NN cord-015306-us58wwmp 3756 5 and and CC cord-015306-us58wwmp 3756 6 extirpation extirpation NN cord-015306-us58wwmp 3756 7 of of IN cord-015306-us58wwmp 3756 8 swelling swell VBG cord-015306-us58wwmp 3756 9 mesenteric mesenteric JJ cord-015306-us58wwmp 3756 10 lymph lymph NN cord-015306-us58wwmp 3756 11 nodes node NNS cord-015306-us58wwmp 3756 12 . . . cord-015306-us58wwmp 3757 1 The the DT cord-015306-us58wwmp 3757 2 pathological pathological JJ cord-015306-us58wwmp 3757 3 finding finding NN cord-015306-us58wwmp 3757 4 of of IN cord-015306-us58wwmp 3757 5 cholecystic cholecystic JJ cord-015306-us58wwmp 3757 6 polyp polyp NN cord-015306-us58wwmp 3757 7 was be VBD cord-015306-us58wwmp 3757 8 EBV EBV NNP cord-015306-us58wwmp 3757 9 encoded encode VBD cord-015306-us58wwmp 3757 10 small small JJ cord-015306-us58wwmp 3757 11 RNA RNA NNP cord-015306-us58wwmp 3757 12 ( ( -LRB- cord-015306-us58wwmp 3757 13 EBER EBER NNP cord-015306-us58wwmp 3757 14 ) ) -RRB- cord-015306-us58wwmp 3757 15 positive positive JJ cord-015306-us58wwmp 3757 16 smooth smooth JJ cord-015306-us58wwmp 3757 17 muscle muscle NN cord-015306-us58wwmp 3757 18 tumor tumor NN cord-015306-us58wwmp 3758 1 but but CC cord-015306-us58wwmp 3758 2 there there EX cord-015306-us58wwmp 3758 3 was be VBD cord-015306-us58wwmp 3758 4 no no DT cord-015306-us58wwmp 3758 5 finding finding NN cord-015306-us58wwmp 3758 6 about about IN cord-015306-us58wwmp 3758 7 post post JJ cord-015306-us58wwmp 3758 8 - - JJ cord-015306-us58wwmp 3758 9 transplant transplant JJ cord-015306-us58wwmp 3758 10 lymphoproliferative lymphoproliferative JJ cord-015306-us58wwmp 3758 11 disorder disorder NN cord-015306-us58wwmp 3758 12 in in IN cord-015306-us58wwmp 3758 13 mesenteric mesenteric JJ cord-015306-us58wwmp 3758 14 lymph lymph NN cord-015306-us58wwmp 3758 15 nodes node NNS cord-015306-us58wwmp 3758 16 . . . cord-015306-us58wwmp 3759 1 Positron positron NN cord-015306-us58wwmp 3759 2 - - HYPH cord-015306-us58wwmp 3759 3 emission emission NN cord-015306-us58wwmp 3759 4 tomography tomography NN cord-015306-us58wwmp 3759 5 ( ( -LRB- cord-015306-us58wwmp 3759 6 PET PET NNP cord-015306-us58wwmp 3759 7 ) ) -RRB- cord-015306-us58wwmp 3759 8 showed show VBD cord-015306-us58wwmp 3759 9 accumulation accumulation NN cord-015306-us58wwmp 3759 10 of of IN cord-015306-us58wwmp 3759 11 1 1 CD cord-015306-us58wwmp 3759 12 cm cm NN cord-015306-us58wwmp 3759 13 mass mass NN cord-015306-us58wwmp 3759 14 around around IN cord-015306-us58wwmp 3759 15 12th 12th NN cord-015306-us58wwmp 3759 16 of of IN cord-015306-us58wwmp 3759 17 thoracic thoracic JJ cord-015306-us58wwmp 3759 18 vertebra vertebra NN cord-015306-us58wwmp 3759 19 and and CC cord-015306-us58wwmp 3759 20 CT CT NNP cord-015306-us58wwmp 3759 21 scan scan NN cord-015306-us58wwmp 3759 22 showed show VBD cord-015306-us58wwmp 3759 23 three three CD cord-015306-us58wwmp 3759 24 small small JJ cord-015306-us58wwmp 3759 25 masses masse NNS cord-015306-us58wwmp 3759 26 in in IN cord-015306-us58wwmp 3759 27 the the DT cord-015306-us58wwmp 3759 28 lung lung NN cord-015306-us58wwmp 3759 29 and and CC cord-015306-us58wwmp 3759 30 one one CD cord-015306-us58wwmp 3759 31 in in IN cord-015306-us58wwmp 3759 32 the the DT cord-015306-us58wwmp 3759 33 liver liver NN cord-015306-us58wwmp 3759 34 . . . cord-015306-us58wwmp 3760 1 We -PRON- PRP cord-015306-us58wwmp 3760 2 diagnosed diagnose VBD cord-015306-us58wwmp 3760 3 her -PRON- PRP cord-015306-us58wwmp 3760 4 suffering suffer VBG cord-015306-us58wwmp 3760 5 multiple multiple JJ cord-015306-us58wwmp 3760 6 infection infection NN cord-015306-us58wwmp 3760 7 of of IN cord-015306-us58wwmp 3760 8 EBV EBV NNP cord-015306-us58wwmp 3760 9 - - HYPH cord-015306-us58wwmp 3760 10 SMT SMT NNP cord-015306-us58wwmp 3760 11 . . . cord-015306-us58wwmp 3761 1 Immunosuppression Immunosuppression NNP cord-015306-us58wwmp 3761 2 therapy therapy NN cord-015306-us58wwmp 3761 3 was be VBD cord-015306-us58wwmp 3761 4 reduced reduce VBN cord-015306-us58wwmp 3761 5 , , , cord-015306-us58wwmp 3761 6 but but CC cord-015306-us58wwmp 3761 7 there there EX cord-015306-us58wwmp 3761 8 was be VBD cord-015306-us58wwmp 3761 9 no no DT cord-015306-us58wwmp 3761 10 change change NN cord-015306-us58wwmp 3761 11 about about IN cord-015306-us58wwmp 3761 12 size size NN cord-015306-us58wwmp 3761 13 of of IN cord-015306-us58wwmp 3761 14 her -PRON- PRP$ cord-015306-us58wwmp 3761 15 tumor tumor NN cord-015306-us58wwmp 3761 16 . . . cord-015306-us58wwmp 3762 1 Rituximab Rituximab NNP cord-015306-us58wwmp 3762 2 was be VBD cord-015306-us58wwmp 3762 3 administered administer VBN cord-015306-us58wwmp 3762 4 for for IN cord-015306-us58wwmp 3762 5 keep keep VB cord-015306-us58wwmp 3762 6 away away RB cord-015306-us58wwmp 3762 7 from from IN cord-015306-us58wwmp 3762 8 repetition repetition NN cord-015306-us58wwmp 3762 9 of of IN cord-015306-us58wwmp 3762 10 tumor tumor NN cord-015306-us58wwmp 3762 11 after after IN cord-015306-us58wwmp 3762 12 proving prove VBG cord-015306-us58wwmp 3762 13 infection infection NN cord-015306-us58wwmp 3762 14 of of IN cord-015306-us58wwmp 3762 15 EBV EBV NNP cord-015306-us58wwmp 3762 16 only only RB cord-015306-us58wwmp 3762 17 in in IN cord-015306-us58wwmp 3762 18 B b NN cord-015306-us58wwmp 3762 19 cells cell NNS cord-015306-us58wwmp 3762 20 by by IN cord-015306-us58wwmp 3762 21 using use VBG cord-015306-us58wwmp 3762 22 flow flow NN cord-015306-us58wwmp 3762 23 cytometry cytometry NN cord-015306-us58wwmp 3762 24 . . . cord-015306-us58wwmp 3763 1 After after IN cord-015306-us58wwmp 3763 2 medication medication NN cord-015306-us58wwmp 3763 3 of of IN cord-015306-us58wwmp 3763 4 rituximab rituximab NN cord-015306-us58wwmp 3763 5 , , , cord-015306-us58wwmp 3763 6 the the DT cord-015306-us58wwmp 3763 7 EBV EBV NNP cord-015306-us58wwmp 3763 8 DNA dna NN cord-015306-us58wwmp 3763 9 counts count NNS cord-015306-us58wwmp 3763 10 were be VBD cord-015306-us58wwmp 3763 11 normalized normalize VBN cord-015306-us58wwmp 3763 12 . . . cord-015306-us58wwmp 3764 1 Ultrasonic ultrasonic JJ cord-015306-us58wwmp 3764 2 examination examination NN cord-015306-us58wwmp 3764 3 detected detect VBD cord-015306-us58wwmp 3764 4 three three CD cord-015306-us58wwmp 3764 5 small small JJ cord-015306-us58wwmp 3764 6 masses masse NNS cord-015306-us58wwmp 3764 7 in in IN cord-015306-us58wwmp 3764 8 liver liver NN cord-015306-us58wwmp 3764 9 and and CC cord-015306-us58wwmp 3764 10 one one CD cord-015306-us58wwmp 3764 11 lymph lymph NN cord-015306-us58wwmp 3764 12 node node NN cord-015306-us58wwmp 3764 13 around around IN cord-015306-us58wwmp 3764 14 main main JJ cord-015306-us58wwmp 3764 15 artery artery NN cord-015306-us58wwmp 3764 16 . . . cord-015306-us58wwmp 3765 1 But but CC cord-015306-us58wwmp 3765 2 her -PRON- PRP$ cord-015306-us58wwmp 3765 3 mass mass NN cord-015306-us58wwmp 3765 4 around around IN cord-015306-us58wwmp 3765 5 12th 12th NN cord-015306-us58wwmp 3765 6 of of IN cord-015306-us58wwmp 3765 7 thoracic thoracic JJ cord-015306-us58wwmp 3765 8 vertebra vertebra NN cord-015306-us58wwmp 3765 9 was be VBD cord-015306-us58wwmp 3765 10 disappeared disappear VBN cord-015306-us58wwmp 3765 11 and and CC cord-015306-us58wwmp 3765 12 whole whole JJ cord-015306-us58wwmp 3765 13 body body NN cord-015306-us58wwmp 3765 14 CT CT NNP cord-015306-us58wwmp 3765 15 scan scan NN cord-015306-us58wwmp 3765 16 detected detect VBD cord-015306-us58wwmp 3765 17 only only RB cord-015306-us58wwmp 3765 18 one one CD cord-015306-us58wwmp 3765 19 small small JJ cord-015306-us58wwmp 3765 20 residual residual JJ cord-015306-us58wwmp 3765 21 mass mass NN cord-015306-us58wwmp 3765 22 in in IN cord-015306-us58wwmp 3765 23 the the DT cord-015306-us58wwmp 3765 24 lung lung NN cord-015306-us58wwmp 3765 25 . . . cord-015306-us58wwmp 3766 1 We -PRON- PRP cord-015306-us58wwmp 3766 2 report report VBP cord-015306-us58wwmp 3766 3 a a DT cord-015306-us58wwmp 3766 4 case case NN cord-015306-us58wwmp 3766 5 of of IN cord-015306-us58wwmp 3766 6 an an DT cord-015306-us58wwmp 3766 7 EBV EBV NNP cord-015306-us58wwmp 3766 8 - - HYPH cord-015306-us58wwmp 3766 9 SMT SMT NNP cord-015306-us58wwmp 3766 10 presenting present VBG cord-015306-us58wwmp 3766 11 multiple multiple JJ cord-015306-us58wwmp 3766 12 infections infection NNS cord-015306-us58wwmp 3766 13 , , , cord-015306-us58wwmp 3766 14 which which WDT cord-015306-us58wwmp 3766 15 was be VBD cord-015306-us58wwmp 3766 16 treated treat VBN cord-015306-us58wwmp 3766 17 with with IN cord-015306-us58wwmp 3766 18 rituximab rituximab NN cord-015306-us58wwmp 3766 19 . . . cord-015306-us58wwmp 3767 1 Rituximab Rituximab NNP cord-015306-us58wwmp 3767 2 may may MD cord-015306-us58wwmp 3767 3 be be VB cord-015306-us58wwmp 3767 4 an an DT cord-015306-us58wwmp 3767 5 effective effective JJ cord-015306-us58wwmp 3767 6 treatment treatment NN cord-015306-us58wwmp 3767 7 for for IN cord-015306-us58wwmp 3767 8 multiple multiple JJ cord-015306-us58wwmp 3767 9 EBV EBV NNP cord-015306-us58wwmp 3767 10 - - HYPH cord-015306-us58wwmp 3767 11 SMT SMT NNP cord-015306-us58wwmp 3768 1 but but CC cord-015306-us58wwmp 3768 2 careful careful JJ cord-015306-us58wwmp 3768 3 observation observation NN cord-015306-us58wwmp 3768 4 is be VBZ cord-015306-us58wwmp 3768 5 also also RB cord-015306-us58wwmp 3768 6 needed need VBN cord-015306-us58wwmp 3768 7 for for IN cord-015306-us58wwmp 3768 8 the the DT cord-015306-us58wwmp 3768 9 reappearence reappearence NN cord-015306-us58wwmp 3768 10 of of IN cord-015306-us58wwmp 3768 11 EBV EBV NNP cord-015306-us58wwmp 3768 12 - - HYPH cord-015306-us58wwmp 3768 13 SMT SMT NNP cord-015306-us58wwmp 3768 14 . . . cord-015306-us58wwmp 3769 1 The the DT cord-015306-us58wwmp 3769 2 usefulness usefulness NN cord-015306-us58wwmp 3769 3 of of IN cord-015306-us58wwmp 3769 4 monitoring monitoring NN cord-015306-us58wwmp 3769 5 of of IN cord-015306-us58wwmp 3769 6 Epstein Epstein NNP cord-015306-us58wwmp 3769 7 - - HYPH cord-015306-us58wwmp 3769 8 Barr Barr NNP cord-015306-us58wwmp 3769 9 viral viral JJ cord-015306-us58wwmp 3769 10 load load NN cord-015306-us58wwmp 3769 11 after after IN cord-015306-us58wwmp 3769 12 renal renal JJ cord-015306-us58wwmp 3769 13 transplantation transplantation NN cord-015306-us58wwmp 3769 14 in in IN cord-015306-us58wwmp 3769 15 pediatric pediatric JJ cord-015306-us58wwmp 3769 16 recipients recipient NNS cord-015306-us58wwmp 3769 17 with with IN cord-015306-us58wwmp 3769 18 EBV EBV NNP cord-015306-us58wwmp 3769 19 seronegative seronegative JJ cord-015306-us58wwmp 3769 20 Objective Objective NNP cord-015306-us58wwmp 3769 21 : : : cord-015306-us58wwmp 3769 22 The the DT cord-015306-us58wwmp 3769 23 purpose purpose NN cord-015306-us58wwmp 3769 24 of of IN cord-015306-us58wwmp 3769 25 this this DT cord-015306-us58wwmp 3769 26 study study NN cord-015306-us58wwmp 3769 27 are be VBP cord-015306-us58wwmp 3769 28 to to TO cord-015306-us58wwmp 3769 29 establish establish VB cord-015306-us58wwmp 3769 30 a a DT cord-015306-us58wwmp 3769 31 protocol protocol NN cord-015306-us58wwmp 3769 32 for for IN cord-015306-us58wwmp 3769 33 monitoring monitor VBG cord-015306-us58wwmp 3769 34 Epstein Epstein NNP cord-015306-us58wwmp 3769 35 - - HYPH cord-015306-us58wwmp 3769 36 Barr Barr NNP cord-015306-us58wwmp 3769 37 virus virus NN cord-015306-us58wwmp 3769 38 ( ( -LRB- cord-015306-us58wwmp 3769 39 EBV EBV NNP cord-015306-us58wwmp 3769 40 ) ) -RRB- cord-015306-us58wwmp 3769 41 infection infection NN cord-015306-us58wwmp 3769 42 for for IN cord-015306-us58wwmp 3769 43 identification identification NN cord-015306-us58wwmp 3769 44 of of IN cord-015306-us58wwmp 3769 45 pediatric pediatric JJ cord-015306-us58wwmp 3769 46 renal renal JJ cord-015306-us58wwmp 3769 47 transplant transplant NN cord-015306-us58wwmp 3769 48 recipients recipient NNS cord-015306-us58wwmp 3769 49 with with IN cord-015306-us58wwmp 3769 50 a a DT cord-015306-us58wwmp 3769 51 high high JJ cord-015306-us58wwmp 3769 52 risk risk NN cord-015306-us58wwmp 3769 53 of of IN cord-015306-us58wwmp 3769 54 developing develop VBG cord-015306-us58wwmp 3769 55 posttransplantlymphoproliferative posttransplantlymphoproliferative JJ cord-015306-us58wwmp 3769 56 disorder disorder NN cord-015306-us58wwmp 3769 57 ( ( -LRB- cord-015306-us58wwmp 3769 58 PTLD PTLD NNP cord-015306-us58wwmp 3769 59 ) ) -RRB- cord-015306-us58wwmp 3769 60 and and CC cord-015306-us58wwmp 3769 61 to to TO cord-015306-us58wwmp 3769 62 predict predict VB cord-015306-us58wwmp 3769 63 the the DT cord-015306-us58wwmp 3769 64 development development NN cord-015306-us58wwmp 3769 65 of of IN cord-015306-us58wwmp 3769 66 PTLD PTLD NNP cord-015306-us58wwmp 3769 67 . . . cord-015306-us58wwmp 3770 1 Methods method NNS cord-015306-us58wwmp 3770 2 : : : cord-015306-us58wwmp 3770 3 Peripheral peripheral JJ cord-015306-us58wwmp 3770 4 blood blood NN cord-015306-us58wwmp 3770 5 mononuclear mononuclear NN cord-015306-us58wwmp 3770 6 cells cell NNS cord-015306-us58wwmp 3770 7 ( ( -LRB- cord-015306-us58wwmp 3770 8 PBMCs pbmc NNS cord-015306-us58wwmp 3770 9 ) ) -RRB- cord-015306-us58wwmp 3770 10 and and CC cord-015306-us58wwmp 3770 11 plasma plasma NN cord-015306-us58wwmp 3770 12 EBV EBV NNP cord-015306-us58wwmp 3770 13 loads load NNS cord-015306-us58wwmp 3770 14 were be VBD cord-015306-us58wwmp 3770 15 measured measure VBN cord-015306-us58wwmp 3770 16 by by IN cord-015306-us58wwmp 3770 17 nested nested JJ cord-015306-us58wwmp 3770 18 PCR PCR NNP cord-015306-us58wwmp 3770 19 ( ( -LRB- cord-015306-us58wwmp 3770 20 n n NNP cord-015306-us58wwmp 3770 21 - - HYPH cord-015306-us58wwmp 3770 22 PCR PCR NNP cord-015306-us58wwmp 3770 23 ) ) -RRB- cord-015306-us58wwmp 3770 24 and and CC cord-015306-us58wwmp 3770 25 real real JJ cord-015306-us58wwmp 3770 26 - - HYPH cord-015306-us58wwmp 3770 27 time time NN cord-015306-us58wwmp 3770 28 PCR PCR NNP cord-015306-us58wwmp 3770 29 ( ( -LRB- cord-015306-us58wwmp 3770 30 r r NN cord-015306-us58wwmp 3770 31 - - HYPH cord-015306-us58wwmp 3770 32 PCR pcr NN cord-015306-us58wwmp 3770 33 ) ) -RRB- cord-015306-us58wwmp 3771 1 every every DT cord-015306-us58wwmp 3771 2 1 1 CD cord-015306-us58wwmp 3771 3 - - SYM cord-015306-us58wwmp 3771 4 3 3 CD cord-015306-us58wwmp 3771 5 months month NNS cord-015306-us58wwmp 3771 6 after after IN cord-015306-us58wwmp 3771 7 grafting graft VBG cord-015306-us58wwmp 3771 8 in in IN cord-015306-us58wwmp 3771 9 17 17 CD cord-015306-us58wwmp 3771 10 pediatric pediatric JJ cord-015306-us58wwmp 3771 11 recipients recipient NNS cord-015306-us58wwmp 3771 12 who who WP cord-015306-us58wwmp 3771 13 were be VBD cord-015306-us58wwmp 3771 14 seronegative seronegative JJ cord-015306-us58wwmp 3771 15 for for IN cord-015306-us58wwmp 3771 16 EBV EBV NNP cord-015306-us58wwmp 3771 17 before before IN cord-015306-us58wwmp 3771 18 grafting grafting NN cord-015306-us58wwmp 3771 19 ( ( -LRB- cord-015306-us58wwmp 3771 20 4 4 CD cord-015306-us58wwmp 3771 21 with with IN cord-015306-us58wwmp 3771 22 EBV EBV NNP cord-015306-us58wwmp 3771 23 - - HYPH cord-015306-us58wwmp 3771 24 associated associate VBN cord-015306-us58wwmp 3771 25 symptoms symptom NNS cord-015306-us58wwmp 3771 26 , , , cord-015306-us58wwmp 3771 27 including include VBG cord-015306-us58wwmp 3771 28 2 2 CD cord-015306-us58wwmp 3771 29 with with IN cord-015306-us58wwmp 3771 30 PTLD PTLD NNP cord-015306-us58wwmp 3771 31 ( ( -LRB- cord-015306-us58wwmp 3771 32 group group NN cord-015306-us58wwmp 3771 33 A A NNP cord-015306-us58wwmp 3771 34 ) ) -RRB- cord-015306-us58wwmp 3771 35 ; ; : cord-015306-us58wwmp 3771 36 6 6 CD cord-015306-us58wwmp 3771 37 with with IN cord-015306-us58wwmp 3771 38 asymptomatic asymptomatic JJ cord-015306-us58wwmp 3771 39 persistent persistent JJ cord-015306-us58wwmp 3771 40 high high JJ cord-015306-us58wwmp 3771 41 EBV EBV NNP cord-015306-us58wwmp 3771 42 loads load NNS cord-015306-us58wwmp 3771 43 in in IN cord-015306-us58wwmp 3771 44 PBMCs pbmc NNS cord-015306-us58wwmp 3771 45 of of IN cord-015306-us58wwmp 3771 46 > > XX cord-015306-us58wwmp 3772 1 1,000 1,000 CD cord-015306-us58wwmp 3772 2 copies copy NNS cord-015306-us58wwmp 3772 3 / / SYM cord-015306-us58wwmp 3772 4 ug ug NNP cord-015306-us58wwmp 3772 5 DNA DNA NNP cord-015306-us58wwmp 3772 6 for for IN cord-015306-us58wwmp 3772 7 over over IN cord-015306-us58wwmp 3772 8 6 6 CD cord-015306-us58wwmp 3772 9 months month NNS cord-015306-us58wwmp 3772 10 ( ( -LRB- cord-015306-us58wwmp 3772 11 group group NN cord-015306-us58wwmp 3772 12 B B NNP cord-015306-us58wwmp 3772 13 ) ) -RRB- cord-015306-us58wwmp 3772 14 ; ; : cord-015306-us58wwmp 3772 15 and and CC cord-015306-us58wwmp 3772 16 7 7 CD cord-015306-us58wwmp 3772 17 with with IN cord-015306-us58wwmp 3772 18 neither neither CC cord-015306-us58wwmp 3772 19 EBV EBV NNP cord-015306-us58wwmp 3772 20 - - HYPH cord-015306-us58wwmp 3772 21 associated associate VBN cord-015306-us58wwmp 3772 22 symptoms symptom NNS cord-015306-us58wwmp 3772 23 nor nor CC cord-015306-us58wwmp 3772 24 persistent persistent JJ cord-015306-us58wwmp 3772 25 high high JJ cord-015306-us58wwmp 3772 26 EBV EBV NNP cord-015306-us58wwmp 3772 27 loads load NNS cord-015306-us58wwmp 3772 28 in in IN cord-015306-us58wwmp 3772 29 PBMCs pbmc NNS cord-015306-us58wwmp 3772 30 ( ( -LRB- cord-015306-us58wwmp 3772 31 group group NN cord-015306-us58wwmp 3772 32 C C NNP cord-015306-us58wwmp 3772 33 ) ) -RRB- cord-015306-us58wwmp 3772 34 . . . cord-015306-us58wwmp 3773 1 EBV EBV NNP cord-015306-us58wwmp 3773 2 - - HYPH cord-015306-us58wwmp 3773 3 CTLs CTLs NNP cord-015306-us58wwmp 3773 4 were be VBD cord-015306-us58wwmp 3773 5 also also RB cord-015306-us58wwmp 3773 6 measured measure VBN cord-015306-us58wwmp 3773 7 in in IN cord-015306-us58wwmp 3773 8 13 13 CD cord-015306-us58wwmp 3773 9 patients patient NNS cord-015306-us58wwmp 3773 10 without without IN cord-015306-us58wwmp 3773 11 EBV EBV NNP cord-015306-us58wwmp 3773 12 - - HYPH cord-015306-us58wwmp 3773 13 associated associate VBN cord-015306-us58wwmp 3773 14 symptoms symptom NNS cord-015306-us58wwmp 3773 15 . . . cord-015306-us58wwmp 3774 1 Results result NNS cord-015306-us58wwmp 3774 2 : : : cord-015306-us58wwmp 3775 1 The the DT cord-015306-us58wwmp 3775 2 EBV EBV NNP cord-015306-us58wwmp 3775 3 genome genome NN cord-015306-us58wwmp 3775 4 detected detect VBN cord-015306-us58wwmp 3775 5 by by IN cord-015306-us58wwmp 3775 6 n n NNP cord-015306-us58wwmp 3775 7 - - HYPH cord-015306-us58wwmp 3775 8 PCR PCR NNP cord-015306-us58wwmp 3775 9 was be VBD cord-015306-us58wwmp 3775 10 present present JJ cord-015306-us58wwmp 3775 11 in in IN cord-015306-us58wwmp 3775 12 plasma plasma NN cord-015306-us58wwmp 3775 13 in in IN cord-015306-us58wwmp 3775 14 3 3 CD cord-015306-us58wwmp 3775 15 ( ( -LRB- cord-015306-us58wwmp 3775 16 75 75 CD cord-015306-us58wwmp 3775 17 % % NN cord-015306-us58wwmp 3775 18 ) ) -RRB- cord-015306-us58wwmp 3775 19 , , , cord-015306-us58wwmp 3775 20 1 1 CD cord-015306-us58wwmp 3775 21 ( ( -LRB- cord-015306-us58wwmp 3775 22 17 17 CD cord-015306-us58wwmp 3775 23 % % NN cord-015306-us58wwmp 3775 24 ) ) -RRB- cord-015306-us58wwmp 3775 25 , , , cord-015306-us58wwmp 3775 26 and and CC cord-015306-us58wwmp 3775 27 0 0 NFP cord-015306-us58wwmp 3775 28 ( ( -LRB- cord-015306-us58wwmp 3775 29 0 0 CD cord-015306-us58wwmp 3775 30 % % NN cord-015306-us58wwmp 3775 31 ) ) -RRB- cord-015306-us58wwmp 3775 32 in in IN cord-015306-us58wwmp 3775 33 groups group NNS cord-015306-us58wwmp 3775 34 A A NNP cord-015306-us58wwmp 3775 35 , , , cord-015306-us58wwmp 3775 36 B b NN cord-015306-us58wwmp 3775 37 and and CC cord-015306-us58wwmp 3775 38 C C NNP cord-015306-us58wwmp 3775 39 ( ( -LRB- cord-015306-us58wwmp 3775 40 p<0.01 p<0.01 NNP cord-015306-us58wwmp 3775 41 for for IN cord-015306-us58wwmp 3775 42 A a DT cord-015306-us58wwmp 3775 43 vs. vs. FW cord-015306-us58wwmp 3775 44 B b NN cord-015306-us58wwmp 3775 45 and and CC cord-015306-us58wwmp 3775 46 A a NN cord-015306-us58wwmp 3775 47 vs. vs. FW cord-015306-us58wwmp 3775 48 C C NNP cord-015306-us58wwmp 3775 49 ) ) -RRB- cord-015306-us58wwmp 3775 50 . . . cord-015306-us58wwmp 3776 1 EBV EBV NNP cord-015306-us58wwmp 3776 2 loads load NNS cord-015306-us58wwmp 3776 3 detected detect VBN cord-015306-us58wwmp 3776 4 by by IN cord-015306-us58wwmp 3776 5 r r NN cord-015306-us58wwmp 3776 6 - - HYPH cord-015306-us58wwmp 3776 7 PCR PCR NNP cord-015306-us58wwmp 3776 8 in in IN cord-015306-us58wwmp 3776 9 PBMCs pbmc NNS cord-015306-us58wwmp 3776 10 were be VBD cord-015306-us58wwmp 3776 11 significantly significantly RB cord-015306-us58wwmp 3776 12 higher high JJR cord-015306-us58wwmp 3776 13 in in IN cord-015306-us58wwmp 3776 14 groups group NNS cord-015306-us58wwmp 3777 1 A a DT cord-015306-us58wwmp 3777 2 ( ( -LRB- cord-015306-us58wwmp 3777 3 p<0.05 p<0.05 CD cord-015306-us58wwmp 3777 4 ) ) -RRB- cord-015306-us58wwmp 3777 5 and and CC cord-015306-us58wwmp 3777 6 B B NNP cord-015306-us58wwmp 3777 7 ( ( -LRB- cord-015306-us58wwmp 3777 8 p<0.01 p<0.01 NN cord-015306-us58wwmp 3777 9 ) ) -RRB- cord-015306-us58wwmp 3778 1 compared compare VBN cord-015306-us58wwmp 3778 2 to to IN cord-015306-us58wwmp 3778 3 group group NN cord-015306-us58wwmp 3778 4 C. C. NNP cord-015306-us58wwmp 3778 5 EBV EBV NNP cord-015306-us58wwmp 3778 6 genomes genome NNS cord-015306-us58wwmp 3778 7 in in IN cord-015306-us58wwmp 3778 8 plasma plasma NN cord-015306-us58wwmp 3778 9 were be VBD cord-015306-us58wwmp 3778 10 detected detect VBN cord-015306-us58wwmp 3778 11 by by IN cord-015306-us58wwmp 3778 12 n n NN cord-015306-us58wwmp 3778 13 - - : cord-015306-us58wwmp 3778 14 and and CC cord-015306-us58wwmp 3778 15 r r NNP cord-015306-us58wwmp 3778 16 - - HYPH cord-015306-us58wwmp 3778 17 PCR PCR NNP cord-015306-us58wwmp 3778 18 in in IN cord-015306-us58wwmp 3778 19 only only RB cord-015306-us58wwmp 3778 20 the the DT cord-015306-us58wwmp 3778 21 2 2 CD cord-015306-us58wwmp 3778 22 cases case NNS cord-015306-us58wwmp 3778 23 with with IN cord-015306-us58wwmp 3778 24 PTLD PTLD NNP cord-015306-us58wwmp 3778 25 . . . cord-015306-us58wwmp 3779 1 One one CD cord-015306-us58wwmp 3779 2 patient patient NN cord-015306-us58wwmp 3779 3 with with IN cord-015306-us58wwmp 3779 4 lymphadenitis lymphadenitis NNP cord-015306-us58wwmp 3779 5 in in IN cord-015306-us58wwmp 3779 6 group group NN cord-015306-us58wwmp 3779 7 A A NNP cord-015306-us58wwmp 3779 8 and and CC cord-015306-us58wwmp 3779 9 1 1 CD cord-015306-us58wwmp 3779 10 patient patient NN cord-015306-us58wwmp 3779 11 in in IN cord-015306-us58wwmp 3779 12 group group NN cord-015306-us58wwmp 3779 13 B B NNP cord-015306-us58wwmp 3779 14 had have VBD cord-015306-us58wwmp 3779 15 EBV EBV NNP cord-015306-us58wwmp 3779 16 - - HYPH cord-015306-us58wwmp 3779 17 DNA DNA NNP cord-015306-us58wwmp 3779 18 in in IN cord-015306-us58wwmp 3779 19 plasma plasma NN cord-015306-us58wwmp 3779 20 based base VBN cord-015306-us58wwmp 3779 21 on on IN cord-015306-us58wwmp 3779 22 n n NNP cord-015306-us58wwmp 3779 23 - - HYPH cord-015306-us58wwmp 3779 24 PCR PCR NNP cord-015306-us58wwmp 3779 25 , , , cord-015306-us58wwmp 3779 26 but but CC cord-015306-us58wwmp 3779 27 the the DT cord-015306-us58wwmp 3779 28 viral viral JJ cord-015306-us58wwmp 3779 29 loads load NNS cord-015306-us58wwmp 3779 30 using use VBG cord-015306-us58wwmp 3779 31 r r NN cord-015306-us58wwmp 3779 32 - - HYPH cord-015306-us58wwmp 3779 33 PCR PCR NNP cord-015306-us58wwmp 3779 34 were be VBD cord-015306-us58wwmp 3779 35 < < XX cord-015306-us58wwmp 3779 36 250 250 CD cord-015306-us58wwmp 3779 37 copies copy NNS cord-015306-us58wwmp 3779 38 / / SYM cord-015306-us58wwmp 3779 39 ml ml NN cord-015306-us58wwmp 3779 40 . . . cord-015306-us58wwmp 3780 1 The the DT cord-015306-us58wwmp 3780 2 CTLs ctl NNS cord-015306-us58wwmp 3780 3 ' ' POS cord-015306-us58wwmp 3780 4 percentage percentage NN cord-015306-us58wwmp 3780 5 was be VBD cord-015306-us58wwmp 3780 6 significantly significantly RB cord-015306-us58wwmp 3780 7 lower low JJR cord-015306-us58wwmp 3780 8 in in IN cord-015306-us58wwmp 3780 9 Group Group NNP cord-015306-us58wwmp 3780 10 B B NNP cord-015306-us58wwmp 3780 11 when when WRB cord-015306-us58wwmp 3780 12 EBV EBV NNP cord-015306-us58wwmp 3780 13 loads load NNS cord-015306-us58wwmp 3780 14 first first RB cord-015306-us58wwmp 3780 15 rose rise VBD cord-015306-us58wwmp 3780 16 above above IN cord-015306-us58wwmp 3780 17 100 100 CD cord-015306-us58wwmp 3780 18 copies copy NNS cord-015306-us58wwmp 3780 19 / / SYM cord-015306-us58wwmp 3780 20 ugDNA ugdna NN cord-015306-us58wwmp 3780 21 . . . cord-015306-us58wwmp 3781 1 Conclusion conclusion NN cord-015306-us58wwmp 3781 2 : : : cord-015306-us58wwmp 3782 1 Plasma plasma NN cord-015306-us58wwmp 3782 2 EBV EBV NNP cord-015306-us58wwmp 3782 3 loads load NNS cord-015306-us58wwmp 3782 4 ( ( -LRB- cord-015306-us58wwmp 3782 5 over over IN cord-015306-us58wwmp 3782 6 250 250 CD cord-015306-us58wwmp 3782 7 copies copy NNS cord-015306-us58wwmp 3782 8 / / SYM cord-015306-us58wwmp 3782 9 ml ml NN cord-015306-us58wwmp 3782 10 ) ) -RRB- cord-015306-us58wwmp 3782 11 estimated estimate VBN cord-015306-us58wwmp 3782 12 by by IN cord-015306-us58wwmp 3782 13 r r NNP cord-015306-us58wwmp 3782 14 - - HYPH cord-015306-us58wwmp 3782 15 PCR PCR NNP cord-015306-us58wwmp 3782 16 and and CC cord-015306-us58wwmp 3782 17 CTLs CTLs NNP cord-015306-us58wwmp 3782 18 ' ' POS cord-015306-us58wwmp 3782 19 monitoring monitoring NN cord-015306-us58wwmp 3782 20 may may MD cord-015306-us58wwmp 3782 21 be be VB cord-015306-us58wwmp 3782 22 useful useful JJ cord-015306-us58wwmp 3782 23 to to TO cord-015306-us58wwmp 3782 24 distinguish distinguish VB cord-015306-us58wwmp 3782 25 PTLD PTLD NNP cord-015306-us58wwmp 3782 26 from from IN cord-015306-us58wwmp 3782 27 other other JJ cord-015306-us58wwmp 3782 28 EBV EBV NNP cord-015306-us58wwmp 3782 29 - - HYPH cord-015306-us58wwmp 3782 30 associated associate VBN cord-015306-us58wwmp 3782 31 diseases disease NNS cord-015306-us58wwmp 3782 32 or or CC cord-015306-us58wwmp 3782 33 asymptomatic asymptomatic JJ cord-015306-us58wwmp 3782 34 viremia viremia NN cord-015306-us58wwmp 3782 35 , , , cord-015306-us58wwmp 3782 36 and and CC cord-015306-us58wwmp 3782 37 to to TO cord-015306-us58wwmp 3782 38 avoid avoid VB cord-015306-us58wwmp 3782 39 PTLD PTLD NNP cord-015306-us58wwmp 3782 40 as as IN cord-015306-us58wwmp 3782 41 patients patient NNS cord-015306-us58wwmp 3782 42 with with IN cord-015306-us58wwmp 3782 43 asymptomatic asymptomatic JJ cord-015306-us58wwmp 3782 44 persistent persistent JJ cord-015306-us58wwmp 3782 45 high high JJ cord-015306-us58wwmp 3782 46 EBV EBV NNP cord-015306-us58wwmp 3782 47 loads load NNS cord-015306-us58wwmp 3782 48 had have VBD cord-015306-us58wwmp 3782 49 higher high JJR cord-015306-us58wwmp 3782 50 EBV EBV NNP cord-015306-us58wwmp 3782 51 loads load NNS cord-015306-us58wwmp 3782 52 and and CC cord-015306-us58wwmp 3782 53 lower low JJR cord-015306-us58wwmp 3782 54 percentages percentage NNS cord-015306-us58wwmp 3782 55 of of IN cord-015306-us58wwmp 3782 56 CTLs ctl NNS cord-015306-us58wwmp 3782 57 . . . cord-015306-us58wwmp 3783 1 Abstract abstract JJ cord-015306-us58wwmp 3783 2 # # NN cord-015306-us58wwmp 3784 1 P p NN cord-015306-us58wwmp 3784 2 - - HYPH cord-015306-us58wwmp 3784 3 SAT437 SAT437 NNP cord-015306-us58wwmp 3784 4 Risk risk NN cord-015306-us58wwmp 3784 5 factors factor NNS cord-015306-us58wwmp 3784 6 for for IN cord-015306-us58wwmp 3784 7 post post JJ cord-015306-us58wwmp 3784 8 - - JJ cord-015306-us58wwmp 3784 9 transplant transplant JJ cord-015306-us58wwmp 3784 10 lymphoproliferative lymphoproliferative JJ cord-015306-us58wwmp 3784 11 disorder disorder NN cord-015306-us58wwmp 3784 12 ( ( -LRB- cord-015306-us58wwmp 3784 13 PTLD PTLD NNP cord-015306-us58wwmp 3784 14 ) ) -RRB- cord-015306-us58wwmp 3784 15 in in IN cord-015306-us58wwmp 3784 16 children child NNS cord-015306-us58wwmp 3784 17 with with IN cord-015306-us58wwmp 3784 18 kidney kidney NN cord-015306-us58wwmp 3784 19 transplantation transplantation NN cord-015306-us58wwmp 3784 20 ( ( -LRB- cord-015306-us58wwmp 3784 21 KTx KTx NNS cord-015306-us58wwmp 3784 22 ) ) -RRB- cord-015306-us58wwmp 3785 1 -A -A : cord-015306-us58wwmp 3785 2 single single JJ cord-015306-us58wwmp 3785 3 center center NN cord-015306-us58wwmp 3785 4 survey survey NN cord-015306-us58wwmp 3785 5 since since IN cord-015306-us58wwmp 3785 6 the the DT cord-015306-us58wwmp 3785 7 introduction introduction NN cord-015306-us58wwmp 3785 8 of of IN cord-015306-us58wwmp 3785 9 tacrolimus tacrolimus NN cord-015306-us58wwmp 3785 10 ( ( -LRB- cord-015306-us58wwmp 3785 11 Tac Tac NNP cord-015306-us58wwmp 3785 12 ) ) -RRB- cord-015306-us58wwmp 3786 1 Since since IN cord-015306-us58wwmp 3786 2 pre pre JJ cord-015306-us58wwmp 3786 3 - - JJ cord-015306-us58wwmp 3786 4 transplant transplant JJ cord-015306-us58wwmp 3786 5 evaluation evaluation NN cord-015306-us58wwmp 3786 6 showed show VBD cord-015306-us58wwmp 3786 7 complete complete JJ cord-015306-us58wwmp 3786 8 obstruction obstruction NN cord-015306-us58wwmp 3786 9 of of IN cord-015306-us58wwmp 3786 10 IVC/ IVC/ NNP cord-015306-us58wwmp 3786 11 iliac iliac NN cord-015306-us58wwmp 3786 12 vein vein NN cord-015306-us58wwmp 3786 13 below below IN cord-015306-us58wwmp 3786 14 diaphragm diaphragm NN cord-015306-us58wwmp 3786 15 , , , cord-015306-us58wwmp 3786 16 she -PRON- PRP cord-015306-us58wwmp 3786 17 had have VBD cord-015306-us58wwmp 3786 18 been be VBN cord-015306-us58wwmp 3786 19 managed manage VBN cord-015306-us58wwmp 3786 20 with with IN cord-015306-us58wwmp 3786 21 peritoneal peritoneal JJ cord-015306-us58wwmp 3786 22 dialysis dialysis NN cord-015306-us58wwmp 3786 23 for for IN cord-015306-us58wwmp 3786 24 7 7 CD cord-015306-us58wwmp 3786 25 years year NNS cord-015306-us58wwmp 3786 26 until until IN cord-015306-us58wwmp 3786 27 January January NNP cord-015306-us58wwmp 3786 28 2012 2012 CD cord-015306-us58wwmp 3786 29 when when WRB cord-015306-us58wwmp 3786 30 she -PRON- PRP cord-015306-us58wwmp 3786 31 received receive VBD cord-015306-us58wwmp 3786 32 a a DT cord-015306-us58wwmp 3786 33 living live VBG cord-015306-us58wwmp 3786 34 donor donor NN cord-015306-us58wwmp 3786 35 kidney kidney NN cord-015306-us58wwmp 3786 36 allograft allograft NN cord-015306-us58wwmp 3786 37 from from IN cord-015306-us58wwmp 3786 38 her -PRON- PRP$ cord-015306-us58wwmp 3786 39 mother mother NN cord-015306-us58wwmp 3786 40 . . . cord-015306-us58wwmp 3787 1 The the DT cord-015306-us58wwmp 3787 2 graft graft NN cord-015306-us58wwmp 3787 3 was be VBD cord-015306-us58wwmp 3787 4 transplanted transplant VBN cord-015306-us58wwmp 3787 5 in in IN cord-015306-us58wwmp 3787 6 a a DT cord-015306-us58wwmp 3787 7 left left JJ cord-015306-us58wwmp 3787 8 orthotopic orthotopic JJ cord-015306-us58wwmp 3787 9 position position NN cord-015306-us58wwmp 3787 10 . . . cord-015306-us58wwmp 3788 1 Venous venous JJ cord-015306-us58wwmp 3788 2 drainage drainage NN cord-015306-us58wwmp 3788 3 was be VBD cord-015306-us58wwmp 3788 4 to to IN cord-015306-us58wwmp 3788 5 the the DT cord-015306-us58wwmp 3788 6 left left JJ cord-015306-us58wwmp 3788 7 ascending ascend VBG cord-015306-us58wwmp 3788 8 lumber lumber NN cord-015306-us58wwmp 3788 9 vein vein NN cord-015306-us58wwmp 3788 10 . . . cord-015306-us58wwmp 3789 1 In in IN cord-015306-us58wwmp 3789 2 addition addition NN cord-015306-us58wwmp 3789 3 , , , cord-015306-us58wwmp 3789 4 a a DT cord-015306-us58wwmp 3789 5 venous venous JJ cord-015306-us58wwmp 3789 6 bypass bypass NN cord-015306-us58wwmp 3789 7 was be VBD cord-015306-us58wwmp 3789 8 made make VBN cord-015306-us58wwmp 3789 9 using use VBG cord-015306-us58wwmp 3789 10 donor donor NN cord-015306-us58wwmp 3789 11 ovarian ovarian JJ cord-015306-us58wwmp 3789 12 vein vein NN cord-015306-us58wwmp 3789 13 between between IN cord-015306-us58wwmp 3789 14 graft graft NN cord-015306-us58wwmp 3789 15 vein vein NN cord-015306-us58wwmp 3789 16 and and CC cord-015306-us58wwmp 3789 17 splenc splenc NN cord-015306-us58wwmp 3789 18 vein vein NN cord-015306-us58wwmp 3789 19 after after IN cord-015306-us58wwmp 3789 20 splenectomy splenectomy NN cord-015306-us58wwmp 3789 21 . . . cord-015306-us58wwmp 3790 1 Such such JJ cord-015306-us58wwmp 3790 2 double double JJ cord-015306-us58wwmp 3790 3 venous venous JJ cord-015306-us58wwmp 3790 4 drainage drainage NN cord-015306-us58wwmp 3790 5 was be VBD cord-015306-us58wwmp 3790 6 working work VBG cord-015306-us58wwmp 3790 7 very very RB cord-015306-us58wwmp 3790 8 well well RB cord-015306-us58wwmp 3790 9 after after IN cord-015306-us58wwmp 3790 10 transplantation transplantation NN cord-015306-us58wwmp 3790 11 . . . cord-015306-us58wwmp 3791 1 There there EX cord-015306-us58wwmp 3791 2 was be VBD cord-015306-us58wwmp 3791 3 no no DT cord-015306-us58wwmp 3791 4 surgical surgical JJ cord-015306-us58wwmp 3791 5 complication complication NN cord-015306-us58wwmp 3791 6 and and CC cord-015306-us58wwmp 3792 1 the the DT cord-015306-us58wwmp 3792 2 serum serum NN cord-015306-us58wwmp 3792 3 creatinine creatinine NN cord-015306-us58wwmp 3792 4 ( ( -LRB- cord-015306-us58wwmp 3792 5 s s NNP cord-015306-us58wwmp 3792 6 - - HYPH cord-015306-us58wwmp 3792 7 Cr Cr NNP cord-015306-us58wwmp 3792 8 ) ) -RRB- cord-015306-us58wwmp 3792 9 during during IN cord-015306-us58wwmp 3792 10 the the DT cord-015306-us58wwmp 3792 11 hospital hospital NN cord-015306-us58wwmp 3792 12 stay stay NN cord-015306-us58wwmp 3792 13 was be VBD cord-015306-us58wwmp 3792 14 0.54mg 0.54mg CD cord-015306-us58wwmp 3792 15 / / SYM cord-015306-us58wwmp 3792 16 dl dl NN cord-015306-us58wwmp 3792 17 . . . cord-015306-us58wwmp 3793 1 At at IN cord-015306-us58wwmp 3793 2 second second JJ cord-015306-us58wwmp 3793 3 month month NN cord-015306-us58wwmp 3793 4 after after IN cord-015306-us58wwmp 3793 5 the the DT cord-015306-us58wwmp 3793 6 transplantation transplantation NN cord-015306-us58wwmp 3793 7 , , , cord-015306-us58wwmp 3793 8 she -PRON- PRP cord-015306-us58wwmp 3793 9 developed develop VBD cord-015306-us58wwmp 3793 10 an an DT cord-015306-us58wwmp 3793 11 increase increase NN cord-015306-us58wwmp 3793 12 of of IN cord-015306-us58wwmp 3793 13 s s NNP cord-015306-us58wwmp 3793 14 - - HYPH cord-015306-us58wwmp 3793 15 Cr Cr NNP cord-015306-us58wwmp 3793 16 with with IN cord-015306-us58wwmp 3793 17 edema edema NN cord-015306-us58wwmp 3793 18 and and CC cord-015306-us58wwmp 3793 19 hypertention hypertention NN cord-015306-us58wwmp 3793 20 . . . cord-015306-us58wwmp 3794 1 However however RB cord-015306-us58wwmp 3794 2 , , , cord-015306-us58wwmp 3794 3 biopsies biopsy NNS cord-015306-us58wwmp 3794 4 of of IN cord-015306-us58wwmp 3794 5 kidney kidney NN cord-015306-us58wwmp 3794 6 allograft allograft NN cord-015306-us58wwmp 3794 7 performed perform VBN cord-015306-us58wwmp 3794 8 at at IN cord-015306-us58wwmp 3794 9 2 2 CD cord-015306-us58wwmp 3794 10 nd nd NNP cord-015306-us58wwmp 3794 11 and and CC cord-015306-us58wwmp 3794 12 4 4 CD cord-015306-us58wwmp 3794 13 th th XX cord-015306-us58wwmp 3794 14 month month NN cord-015306-us58wwmp 3794 15 after after IN cord-015306-us58wwmp 3794 16 the the DT cord-015306-us58wwmp 3794 17 transplantation transplantation NN cord-015306-us58wwmp 3794 18 revealed reveal VBD cord-015306-us58wwmp 3794 19 no no DT cord-015306-us58wwmp 3794 20 evidence evidence NN cord-015306-us58wwmp 3794 21 of of IN cord-015306-us58wwmp 3794 22 acute acute JJ cord-015306-us58wwmp 3794 23 rejection rejection NN cord-015306-us58wwmp 3794 24 . . . cord-015306-us58wwmp 3795 1 Hypertention Hypertention NNP cord-015306-us58wwmp 3795 2 was be VBD cord-015306-us58wwmp 3795 3 difficult difficult JJ cord-015306-us58wwmp 3795 4 to to TO cord-015306-us58wwmp 3795 5 control control VB cord-015306-us58wwmp 3795 6 even even RB cord-015306-us58wwmp 3795 7 with with IN cord-015306-us58wwmp 3795 8 a a DT cord-015306-us58wwmp 3795 9 maximum maximum JJ cord-015306-us58wwmp 3795 10 dose dose NN cord-015306-us58wwmp 3795 11 of of IN cord-015306-us58wwmp 3795 12 calcium calcium NN cord-015306-us58wwmp 3795 13 blocker blocker NN cord-015306-us58wwmp 3795 14 , , , cord-015306-us58wwmp 3795 15 and and CC cord-015306-us58wwmp 3795 16 a a DT cord-015306-us58wwmp 3795 17 temporary temporary JJ cord-015306-us58wwmp 3795 18 increase increase NN cord-015306-us58wwmp 3795 19 of of IN cord-015306-us58wwmp 3795 20 the the DT cord-015306-us58wwmp 3795 21 s s NNP cord-015306-us58wwmp 3795 22 - - HYPH cord-015306-us58wwmp 3795 23 Cr Cr NNP cord-015306-us58wwmp 3795 24 up up IN cord-015306-us58wwmp 3795 25 to to TO cord-015306-us58wwmp 3795 26 1.30 1.30 CD cord-015306-us58wwmp 3795 27 mg mg NNP cord-015306-us58wwmp 3795 28 / / SYM cord-015306-us58wwmp 3795 29 dl dl NNP cord-015306-us58wwmp 3795 30 was be VBD cord-015306-us58wwmp 3795 31 noted note VBN cord-015306-us58wwmp 3795 32 when when WRB cord-015306-us58wwmp 3795 33 angiotensin angiotensin NN cord-015306-us58wwmp 3795 34 II II NNP cord-015306-us58wwmp 3795 35 receptor receptor NN cord-015306-us58wwmp 3795 36 blocker blocker NN cord-015306-us58wwmp 3795 37 was be VBD cord-015306-us58wwmp 3795 38 administrated administrate VBN cord-015306-us58wwmp 3795 39 . . . cord-015306-us58wwmp 3796 1 By by IN cord-015306-us58wwmp 3796 2 the the DT cord-015306-us58wwmp 3796 3 ultrasonography ultrasonography NN cord-015306-us58wwmp 3796 4 , , , cord-015306-us58wwmp 3796 5 the the DT cord-015306-us58wwmp 3796 6 maximum maximum JJ cord-015306-us58wwmp 3796 7 arterial arterial JJ cord-015306-us58wwmp 3796 8 blood blood NN cord-015306-us58wwmp 3796 9 flow flow NN cord-015306-us58wwmp 3796 10 of of IN cord-015306-us58wwmp 3796 11 the the DT cord-015306-us58wwmp 3796 12 kidney kidney NN cord-015306-us58wwmp 3796 13 allograft allograft NN cord-015306-us58wwmp 3796 14 was be VBD cord-015306-us58wwmp 3796 15 high high JJ cord-015306-us58wwmp 3796 16 enough enough RB cord-015306-us58wwmp 3796 17 ( ( -LRB- cord-015306-us58wwmp 3796 18 459cm 459cm NNP cord-015306-us58wwmp 3796 19 / / SYM cord-015306-us58wwmp 3796 20 s s NN cord-015306-us58wwmp 3796 21 ) ) -RRB- cord-015306-us58wwmp 3796 22 to to TO cord-015306-us58wwmp 3796 23 suggest suggest VB cord-015306-us58wwmp 3796 24 renal renal JJ cord-015306-us58wwmp 3796 25 arterial arterial JJ cord-015306-us58wwmp 3796 26 stenosis stenosis NN cord-015306-us58wwmp 3796 27 . . . cord-015306-us58wwmp 3797 1 Moreover moreover RB cord-015306-us58wwmp 3797 2 , , , cord-015306-us58wwmp 3797 3 severe severe JJ cord-015306-us58wwmp 3797 4 renal renal JJ cord-015306-us58wwmp 3797 5 arterial arterial JJ cord-015306-us58wwmp 3797 6 stenosis stenosis NN cord-015306-us58wwmp 3797 7 was be VBD cord-015306-us58wwmp 3797 8 clearly clearly RB cord-015306-us58wwmp 3797 9 shown show VBN cord-015306-us58wwmp 3797 10 for for IN cord-015306-us58wwmp 3797 11 about about RB cord-015306-us58wwmp 3797 12 10 10 CD cord-015306-us58wwmp 3797 13 mm mm CD cord-015306-us58wwmp 3797 14 length length NN cord-015306-us58wwmp 3797 15 from from IN cord-015306-us58wwmp 3797 16 the the DT cord-015306-us58wwmp 3797 17 anastomosed anastomosed JJ cord-015306-us58wwmp 3797 18 site site NN cord-015306-us58wwmp 3797 19 of of IN cord-015306-us58wwmp 3797 20 Aorta Aorta NNP cord-015306-us58wwmp 3797 21 by by IN cord-015306-us58wwmp 3797 22 the the DT cord-015306-us58wwmp 3797 23 contrasting contrast VBG cord-015306-us58wwmp 3797 24 CT.For CT.For NNP cord-015306-us58wwmp 3797 25 the the DT cord-015306-us58wwmp 3797 26 treatment treatment NN cord-015306-us58wwmp 3797 27 of of IN cord-015306-us58wwmp 3797 28 artery artery NN cord-015306-us58wwmp 3797 29 stenosis stenosis NN cord-015306-us58wwmp 3797 30 of of IN cord-015306-us58wwmp 3797 31 the the DT cord-015306-us58wwmp 3797 32 kidney kidney NN cord-015306-us58wwmp 3797 33 allograft allograft NN cord-015306-us58wwmp 3797 34 , , , cord-015306-us58wwmp 3797 35 percutaneous percutaneous JJ cord-015306-us58wwmp 3797 36 transluminal transluminal NNP cord-015306-us58wwmp 3797 37 renal renal JJ cord-015306-us58wwmp 3797 38 angioplasty angioplasty NNP cord-015306-us58wwmp 3797 39 ( ( -LRB- cord-015306-us58wwmp 3797 40 PTRA PTRA NNP cord-015306-us58wwmp 3797 41 ) ) -RRB- cord-015306-us58wwmp 3797 42 was be VBD cord-015306-us58wwmp 3797 43 performed perform VBN cord-015306-us58wwmp 3797 44 at at IN cord-015306-us58wwmp 3797 45 8 8 CD cord-015306-us58wwmp 3797 46 th th CD cord-015306-us58wwmp 3797 47 month month NN cord-015306-us58wwmp 3797 48 after after IN cord-015306-us58wwmp 3797 49 the the DT cord-015306-us58wwmp 3797 50 transplantation transplantation NN cord-015306-us58wwmp 3797 51 . . . cord-015306-us58wwmp 3798 1 The the DT cord-015306-us58wwmp 3798 2 stenotic stenotic JJ cord-015306-us58wwmp 3798 3 lesion lesion NN cord-015306-us58wwmp 3798 4 was be VBD cord-015306-us58wwmp 3798 5 expanded expand VBN cord-015306-us58wwmp 3798 6 using use VBG cord-015306-us58wwmp 3798 7 the the DT cord-015306-us58wwmp 3798 8 special special JJ cord-015306-us58wwmp 3798 9 dilatation dilatation NN cord-015306-us58wwmp 3798 10 balloon balloon NN cord-015306-us58wwmp 3798 11 from from IN cord-015306-us58wwmp 3798 12 1.7 1.7 CD cord-015306-us58wwmp 3798 13 mm mm NNS cord-015306-us58wwmp 3798 14 through through IN cord-015306-us58wwmp 3798 15 2.0 2.0 CD cord-015306-us58wwmp 3798 16 mm mm NNS cord-015306-us58wwmp 3798 17 in in IN cord-015306-us58wwmp 3798 18 diameter diameter NN cord-015306-us58wwmp 3798 19 . . . cord-015306-us58wwmp 3799 1 Because because IN cord-015306-us58wwmp 3799 2 intravascular intravascular JJ cord-015306-us58wwmp 3799 3 ultrasonography ultrasonography NN cord-015306-us58wwmp 3799 4 showed show VBD cord-015306-us58wwmp 3799 5 no no DT cord-015306-us58wwmp 3799 6 intimal intimal JJ cord-015306-us58wwmp 3799 7 thickening thickening NN cord-015306-us58wwmp 3799 8 of of IN cord-015306-us58wwmp 3799 9 the the DT cord-015306-us58wwmp 3799 10 blood blood NN cord-015306-us58wwmp 3799 11 vessel vessel NN cord-015306-us58wwmp 3799 12 , , , cord-015306-us58wwmp 3799 13 a a DT cord-015306-us58wwmp 3799 14 vascular vascular JJ cord-015306-us58wwmp 3799 15 stent stent NN cord-015306-us58wwmp 3799 16 was be VBD cord-015306-us58wwmp 3799 17 not not RB cord-015306-us58wwmp 3799 18 placed place VBN cord-015306-us58wwmp 3799 19 . . . cord-015306-us58wwmp 3800 1 After after IN cord-015306-us58wwmp 3800 2 the the DT cord-015306-us58wwmp 3800 3 PTRA PTRA NNS cord-015306-us58wwmp 3800 4 , , , cord-015306-us58wwmp 3800 5 s s NNP cord-015306-us58wwmp 3800 6 - - HYPH cord-015306-us58wwmp 3800 7 Cr Cr NNP cord-015306-us58wwmp 3800 8 was be VBD cord-015306-us58wwmp 3800 9 decreased decrease VBN cord-015306-us58wwmp 3800 10 to to IN cord-015306-us58wwmp 3800 11 0.5mg 0.5mg CD cord-015306-us58wwmp 3800 12 / / SYM cord-015306-us58wwmp 3800 13 dl dl NN cord-015306-us58wwmp 3800 14 , , , cord-015306-us58wwmp 3800 15 and and CC cord-015306-us58wwmp 3800 16 the the DT cord-015306-us58wwmp 3800 17 blood blood NN cord-015306-us58wwmp 3800 18 pressure pressure NN cord-015306-us58wwmp 3800 19 became become VBD cord-015306-us58wwmp 3800 20 controllable controllable JJ cord-015306-us58wwmp 3800 21 by by IN cord-015306-us58wwmp 3800 22 antihypertensive antihypertensive JJ cord-015306-us58wwmp 3800 23 agents agent NNS cord-015306-us58wwmp 3800 24 . . . cord-015306-us58wwmp 3801 1 Moreover moreover RB cord-015306-us58wwmp 3801 2 , , , cord-015306-us58wwmp 3801 3 the the DT cord-015306-us58wwmp 3801 4 angiography angiography NN cord-015306-us58wwmp 3801 5 performed perform VBD cord-015306-us58wwmp 3801 6 4 4 CD cord-015306-us58wwmp 3801 7 months month NNS cord-015306-us58wwmp 3801 8 after after IN cord-015306-us58wwmp 3801 9 the the DT cord-015306-us58wwmp 3801 10 PTRA PTRA NNP cord-015306-us58wwmp 3801 11 revealed reveal VBD cord-015306-us58wwmp 3801 12 no no DT cord-015306-us58wwmp 3801 13 progression progression NN cord-015306-us58wwmp 3801 14 of of IN cord-015306-us58wwmp 3801 15 arterial arterial JJ cord-015306-us58wwmp 3801 16 stenosis stenosis NN cord-015306-us58wwmp 3801 17 . . . cord-015306-us58wwmp 3802 1 The the DT cord-015306-us58wwmp 3802 2 s s NNP cord-015306-us58wwmp 3802 3 - - HYPH cord-015306-us58wwmp 3802 4 Cr Cr NNP cord-015306-us58wwmp 3802 5 of of IN cord-015306-us58wwmp 3802 6 this this DT cord-015306-us58wwmp 3802 7 patient patient NN cord-015306-us58wwmp 3802 8 is be VBZ cord-015306-us58wwmp 3802 9 now now RB cord-015306-us58wwmp 3802 10 stable stable JJ cord-015306-us58wwmp 3802 11 in in IN cord-015306-us58wwmp 3802 12 0.7 0.7 CD cord-015306-us58wwmp 3802 13 mg mg NNP cord-015306-us58wwmp 3802 14 / / SYM cord-015306-us58wwmp 3802 15 dl dl NN cord-015306-us58wwmp 3802 16 . . . cord-015306-us58wwmp 3803 1 Post post JJ cord-015306-us58wwmp 3803 2 - - JJ cord-015306-us58wwmp 3803 3 transplant transplant JJ cord-015306-us58wwmp 3803 4 encapsulating encapsulate VBG cord-015306-us58wwmp 3803 5 peritoneal peritoneal JJ cord-015306-us58wwmp 3803 6 sclerosis sclerosis NN cord-015306-us58wwmp 3803 7 in in IN cord-015306-us58wwmp 3803 8 children child NNS cord-015306-us58wwmp 3803 9 : : : cord-015306-us58wwmp 3803 10 a a DT cord-015306-us58wwmp 3803 11 single single JJ cord-015306-us58wwmp 3803 12 center center NN cord-015306-us58wwmp 3803 13 experience experience NN cord-015306-us58wwmp 3803 14 Kei Kei NNP cord-015306-us58wwmp 3803 15 Nishiyama Nishiyama NNP cord-015306-us58wwmp 3803 16 Tokyo Tokyo NNP cord-015306-us58wwmp 3803 17 women woman NNS cord-015306-us58wwmp 3803 18 's 's POS cord-015306-us58wwmp 3803 19 mdical mdical JJ cord-015306-us58wwmp 3803 20 university university NN cord-015306-us58wwmp 3803 21 , , , cord-015306-us58wwmp 3803 22 pediatric pediatric JJ cord-015306-us58wwmp 3803 23 nephrology nephrology NN cord-015306-us58wwmp 3803 24 , , , cord-015306-us58wwmp 3803 25 Tokyo Tokyo NNP cord-015306-us58wwmp 3803 26 , , , cord-015306-us58wwmp 3804 1 Japan Japan NNP cord-015306-us58wwmp 3804 2 Objective Objective NNP cord-015306-us58wwmp 3804 3 : : : cord-015306-us58wwmp 3804 4 A a DT cord-015306-us58wwmp 3804 5 substantial substantial JJ cord-015306-us58wwmp 3804 6 proportion proportion NN cord-015306-us58wwmp 3804 7 of of IN cord-015306-us58wwmp 3804 8 encapsulating encapsulate VBG cord-015306-us58wwmp 3804 9 peritoneal peritoneal JJ cord-015306-us58wwmp 3804 10 sclerosis sclerosis NN cord-015306-us58wwmp 3804 11 ( ( -LRB- cord-015306-us58wwmp 3804 12 EPS EPS NNP cord-015306-us58wwmp 3804 13 ) ) -RRB- cord-015306-us58wwmp 3804 14 cases case NNS cord-015306-us58wwmp 3804 15 develop develop VBP cord-015306-us58wwmp 3804 16 after after IN cord-015306-us58wwmp 3804 17 renal renal JJ cord-015306-us58wwmp 3804 18 transplantation transplantation NN cord-015306-us58wwmp 3804 19 ( ( -LRB- cord-015306-us58wwmp 3804 20 RT RT NNP cord-015306-us58wwmp 3804 21 ) ) -RRB- cord-015306-us58wwmp 3804 22 , , , cord-015306-us58wwmp 3804 23 an an DT cord-015306-us58wwmp 3804 24 entity entity NN cord-015306-us58wwmp 3804 25 known know VBN cord-015306-us58wwmp 3804 26 as as IN cord-015306-us58wwmp 3804 27 post post JJ cord-015306-us58wwmp 3804 28 - - JJ cord-015306-us58wwmp 3804 29 transplant transplant JJ cord-015306-us58wwmp 3804 30 EPS eps NN cord-015306-us58wwmp 3804 31 . . . cord-015306-us58wwmp 3805 1 Although although IN cord-015306-us58wwmp 3805 2 risk risk NN cord-015306-us58wwmp 3805 3 factors factor NNS cord-015306-us58wwmp 3805 4 for for IN cord-015306-us58wwmp 3805 5 EPS ep NNS cord-015306-us58wwmp 3805 6 include include VBP cord-015306-us58wwmp 3805 7 prolonged prolong VBN cord-015306-us58wwmp 3805 8 PD PD NNP cord-015306-us58wwmp 3805 9 , , , cord-015306-us58wwmp 3805 10 recurrent recurrent JJ cord-015306-us58wwmp 3805 11 peritonitis peritonitis NN cord-015306-us58wwmp 3805 12 , , , cord-015306-us58wwmp 3805 13 decreased decrease VBD cord-015306-us58wwmp 3805 14 ultrafiltration ultrafiltration NN cord-015306-us58wwmp 3805 15 and and CC cord-015306-us58wwmp 3805 16 prolonged prolonged JJ cord-015306-us58wwmp 3805 17 administration administration NN cord-015306-us58wwmp 3805 18 of of IN cord-015306-us58wwmp 3805 19 hypertonic hypertonic JJ cord-015306-us58wwmp 3805 20 glucose glucose NN cord-015306-us58wwmp 3805 21 or or CC cord-015306-us58wwmp 3805 22 icodextrin icodextrin NN cord-015306-us58wwmp 3805 23 , , , cord-015306-us58wwmp 3805 24 the the DT cord-015306-us58wwmp 3805 25 pathophysiology pathophysiology NN cord-015306-us58wwmp 3805 26 of of IN cord-015306-us58wwmp 3805 27 post post JJ cord-015306-us58wwmp 3805 28 - - JJ cord-015306-us58wwmp 3805 29 transplant transplant NN cord-015306-us58wwmp 3805 30 EPS eps NN cord-015306-us58wwmp 3805 31 is be VBZ cord-015306-us58wwmp 3805 32 largely largely RB cord-015306-us58wwmp 3805 33 unknown unknown JJ cord-015306-us58wwmp 3805 34 . . . cord-015306-us58wwmp 3806 1 However however RB cord-015306-us58wwmp 3806 2 it -PRON- PRP cord-015306-us58wwmp 3806 3 has have VBZ cord-015306-us58wwmp 3806 4 been be VBN cord-015306-us58wwmp 3806 5 postulated postulate VBN cord-015306-us58wwmp 3806 6 that that IN cord-015306-us58wwmp 3806 7 the the DT cord-015306-us58wwmp 3806 8 use use NN cord-015306-us58wwmp 3806 9 of of IN cord-015306-us58wwmp 3806 10 calcineurin calcineurin NNP cord-015306-us58wwmp 3806 11 inhibitors inhibitor NNS cord-015306-us58wwmp 3806 12 ( ( -LRB- cord-015306-us58wwmp 3806 13 CNIs cni NNS cord-015306-us58wwmp 3806 14 ) ) -RRB- cord-015306-us58wwmp 3806 15 after after IN cord-015306-us58wwmp 3806 16 transplantation transplantation NN cord-015306-us58wwmp 3806 17 may may MD cord-015306-us58wwmp 3806 18 promote promote VB cord-015306-us58wwmp 3806 19 EPS EPS NNP cord-015306-us58wwmp 3806 20 , , , cord-015306-us58wwmp 3806 21 as as IN cord-015306-us58wwmp 3806 22 these these DT cord-015306-us58wwmp 3806 23 drugs drug NNS cord-015306-us58wwmp 3806 24 are be VBP cord-015306-us58wwmp 3806 25 considered consider VBN cord-015306-us58wwmp 3806 26 profibrotic profibrotic JJ cord-015306-us58wwmp 3806 27 . . . cord-015306-us58wwmp 3807 1 A a DT cord-015306-us58wwmp 3807 2 recent recent JJ cord-015306-us58wwmp 3807 3 Scottish scottish JJ cord-015306-us58wwmp 3807 4 study study NN cord-015306-us58wwmp 3807 5 showed show VBD cord-015306-us58wwmp 3807 6 that that IN cord-015306-us58wwmp 3807 7 the the DT cord-015306-us58wwmp 3807 8 contribution contribution NN cord-015306-us58wwmp 3807 9 of of IN cord-015306-us58wwmp 3807 10 post post JJ cord-015306-us58wwmp 3807 11 - - JJ cord-015306-us58wwmp 3807 12 transplant transplant NN cord-015306-us58wwmp 3807 13 EPS eps NN cord-015306-us58wwmp 3807 14 might may MD cord-015306-us58wwmp 3807 15 be be VB cord-015306-us58wwmp 3807 16 even even RB cord-015306-us58wwmp 3807 17 as as RB cord-015306-us58wwmp 3807 18 much much JJ cord-015306-us58wwmp 3807 19 as as IN cord-015306-us58wwmp 3807 20 50 50 CD cord-015306-us58wwmp 3807 21 % % NN cord-015306-us58wwmp 3807 22 of of IN cord-015306-us58wwmp 3807 23 the the DT cord-015306-us58wwmp 3807 24 total total JJ cord-015306-us58wwmp 3807 25 EPS EPS NNP cord-015306-us58wwmp 3807 26 patients patient NNS cord-015306-us58wwmp 3807 27 . . . cord-015306-us58wwmp 3808 1 By by IN cord-015306-us58wwmp 3808 2 contrast contrast JJ cord-015306-us58wwmp 3808 3 pediatric pediatric JJ cord-015306-us58wwmp 3808 4 cases case NNS cord-015306-us58wwmp 3808 5 are be VBP cord-015306-us58wwmp 3808 6 very very RB cord-015306-us58wwmp 3808 7 rare rare JJ cord-015306-us58wwmp 3808 8 . . . cord-015306-us58wwmp 3809 1 Therefore therefore RB cord-015306-us58wwmp 3809 2 we -PRON- PRP cord-015306-us58wwmp 3809 3 examined examine VBD cord-015306-us58wwmp 3809 4 the the DT cord-015306-us58wwmp 3809 5 incidence incidence NN cord-015306-us58wwmp 3809 6 of of IN cord-015306-us58wwmp 3809 7 post post JJ cord-015306-us58wwmp 3809 8 - - JJ cord-015306-us58wwmp 3809 9 transplant transplant JJ cord-015306-us58wwmp 3809 10 EPS eps NN cord-015306-us58wwmp 3809 11 in in IN cord-015306-us58wwmp 3809 12 pediatric pediatric JJ cord-015306-us58wwmp 3809 13 renal renal JJ cord-015306-us58wwmp 3809 14 transplant transplant NN cord-015306-us58wwmp 3809 15 recipients recipient NNS cord-015306-us58wwmp 3809 16 . . . cord-015306-us58wwmp 3810 1 Methods method NNS cord-015306-us58wwmp 3810 2 : : : cord-015306-us58wwmp 3810 3 In in IN cord-015306-us58wwmp 3810 4 this this DT cord-015306-us58wwmp 3810 5 study study NN cord-015306-us58wwmp 3810 6 , , , cord-015306-us58wwmp 3810 7 we -PRON- PRP cord-015306-us58wwmp 3810 8 retrospectively retrospectively RB cord-015306-us58wwmp 3810 9 investigated investigate VBD cord-015306-us58wwmp 3810 10 clinical clinical JJ cord-015306-us58wwmp 3810 11 records record NNS cord-015306-us58wwmp 3810 12 from from IN cord-015306-us58wwmp 3810 13 52 52 CD cord-015306-us58wwmp 3810 14 consecutive consecutive JJ cord-015306-us58wwmp 3810 15 pediatric pediatric JJ cord-015306-us58wwmp 3810 16 renal renal JJ cord-015306-us58wwmp 3810 17 transplant transplant NN cord-015306-us58wwmp 3810 18 recipients recipient NNS cord-015306-us58wwmp 3810 19 in in IN cord-015306-us58wwmp 3810 20 our -PRON- PRP$ cord-015306-us58wwmp 3810 21 center center NN cord-015306-us58wwmp 3810 22 between between IN cord-015306-us58wwmp 3810 23 2007 2007 CD cord-015306-us58wwmp 3810 24 to to IN cord-015306-us58wwmp 3810 25 2012 2012 CD cord-015306-us58wwmp 3810 26 , , , cord-015306-us58wwmp 3810 27 who who WP cord-015306-us58wwmp 3810 28 performed perform VBD cord-015306-us58wwmp 3810 29 PD PD NNP cord-015306-us58wwmp 3810 30 before before IN cord-015306-us58wwmp 3810 31 transplantation transplantation NN cord-015306-us58wwmp 3810 32 . . . cord-015306-us58wwmp 3811 1 Clinical clinical JJ cord-015306-us58wwmp 3811 2 parameters parameter NNS cord-015306-us58wwmp 3811 3 and and CC cord-015306-us58wwmp 3811 4 PD pd NN cord-015306-us58wwmp 3811 5 - - HYPH cord-015306-us58wwmp 3811 6 related relate VBN cord-015306-us58wwmp 3811 7 risk risk NN cord-015306-us58wwmp 3811 8 factors factor NNS cord-015306-us58wwmp 3811 9 of of IN cord-015306-us58wwmp 3811 10 EPS EPS NNP cord-015306-us58wwmp 3811 11 were be VBD cord-015306-us58wwmp 3811 12 collected collect VBN cord-015306-us58wwmp 3811 13 at at IN cord-015306-us58wwmp 3811 14 the the DT cord-015306-us58wwmp 3811 15 time time NN cord-015306-us58wwmp 3811 16 of of IN cord-015306-us58wwmp 3811 17 RT RT NNP cord-015306-us58wwmp 3811 18 . . . cord-015306-us58wwmp 3812 1 Transplant transplant NN cord-015306-us58wwmp 3812 2 - - HYPH cord-015306-us58wwmp 3812 3 related relate VBN cord-015306-us58wwmp 3812 4 variables variable NNS cord-015306-us58wwmp 3812 5 were be VBD cord-015306-us58wwmp 3812 6 also also RB cord-015306-us58wwmp 3812 7 collected collect VBN cord-015306-us58wwmp 3812 8 . . . cord-015306-us58wwmp 3813 1 EPS eps NN cord-015306-us58wwmp 3813 2 cases case NNS cord-015306-us58wwmp 3813 3 who who WP cord-015306-us58wwmp 3813 4 met meet VBD cord-015306-us58wwmp 3813 5 ISPD ISPD NNP cord-015306-us58wwmp 3813 6 diagnostic diagnostic JJ cord-015306-us58wwmp 3813 7 criteria criterion NNS cord-015306-us58wwmp 3813 8 including include VBG cord-015306-us58wwmp 3813 9 clinical clinical JJ cord-015306-us58wwmp 3813 10 feature feature NN cord-015306-us58wwmp 3813 11 and and CC cord-015306-us58wwmp 3813 12 either either CC cord-015306-us58wwmp 3813 13 radiologic radiologic JJ cord-015306-us58wwmp 3813 14 and/or and/or CC cord-015306-us58wwmp 3813 15 histopathological histopathological JJ cord-015306-us58wwmp 3813 16 confirmation confirmation NN cord-015306-us58wwmp 3813 17 were be VBD cord-015306-us58wwmp 3813 18 examined examine VBN cord-015306-us58wwmp 3813 19 . . . cord-015306-us58wwmp 3814 1 Results result NNS cord-015306-us58wwmp 3814 2 : : : cord-015306-us58wwmp 3815 1 The the DT cord-015306-us58wwmp 3815 2 median median JJ cord-015306-us58wwmp 3815 3 duration duration NN cord-015306-us58wwmp 3815 4 of of IN cord-015306-us58wwmp 3815 5 PD PD NNP cord-015306-us58wwmp 3815 6 was be VBD cord-015306-us58wwmp 3815 7 2.0 2.0 CD cord-015306-us58wwmp 3815 8 yr yr NN cord-015306-us58wwmp 3815 9 ( ( -LRB- cord-015306-us58wwmp 3815 10 range range VBP cord-015306-us58wwmp 3815 11 0.5 0.5 CD cord-015306-us58wwmp 3815 12 to to IN cord-015306-us58wwmp 3815 13 7.9 7.9 CD cord-015306-us58wwmp 3815 14 ) ) -RRB- cord-015306-us58wwmp 3815 15 . . . cord-015306-us58wwmp 3816 1 Twelve twelve CD cord-015306-us58wwmp 3816 2 patients patient NNS cord-015306-us58wwmp 3816 3 ( ( -LRB- cord-015306-us58wwmp 3816 4 23.1 23.1 CD cord-015306-us58wwmp 3816 5 % % NN cord-015306-us58wwmp 3816 6 ) ) -RRB- cord-015306-us58wwmp 3816 7 had have VBD cord-015306-us58wwmp 3816 8 at at RB cord-015306-us58wwmp 3816 9 least least RBS cord-015306-us58wwmp 3816 10 one one CD cord-015306-us58wwmp 3816 11 episode episode NN cord-015306-us58wwmp 3816 12 of of IN cord-015306-us58wwmp 3816 13 peritonitis peritonitis NN cord-015306-us58wwmp 3816 14 . . . cord-015306-us58wwmp 3817 1 Ten ten CD cord-015306-us58wwmp 3817 2 patients patient NNS cord-015306-us58wwmp 3817 3 ( ( -LRB- cord-015306-us58wwmp 3817 4 19.2 19.2 CD cord-015306-us58wwmp 3817 5 % % NN cord-015306-us58wwmp 3817 6 ) ) -RRB- cord-015306-us58wwmp 3817 7 were be VBD cord-015306-us58wwmp 3817 8 administered administer VBN cord-015306-us58wwmp 3817 9 hypertonic hypertonic JJ cord-015306-us58wwmp 3817 10 glucose glucose NN cord-015306-us58wwmp 3817 11 and/or and/or CC cord-015306-us58wwmp 3817 12 icodextrin icodextrin NN cord-015306-us58wwmp 3817 13 . . . cord-015306-us58wwmp 3818 1 The the DT cord-015306-us58wwmp 3818 2 median median JJ cord-015306-us58wwmp 3818 3 follow follow NN cord-015306-us58wwmp 3818 4 - - HYPH cord-015306-us58wwmp 3818 5 up up NN cord-015306-us58wwmp 3818 6 period period NN cord-015306-us58wwmp 3818 7 after after IN cord-015306-us58wwmp 3818 8 transplantation transplantation NN cord-015306-us58wwmp 3818 9 was be VBD cord-015306-us58wwmp 3818 10 2.3 2.3 CD cord-015306-us58wwmp 3818 11 yr yr NN cord-015306-us58wwmp 3818 12 ( ( -LRB- cord-015306-us58wwmp 3818 13 range range VBP cord-015306-us58wwmp 3818 14 0.3 0.3 CD cord-015306-us58wwmp 3818 15 to to IN cord-015306-us58wwmp 3818 16 5.8 5.8 CD cord-015306-us58wwmp 3818 17 ) ) -RRB- cord-015306-us58wwmp 3818 18 . . . cord-015306-us58wwmp 3819 1 All all DT cord-015306-us58wwmp 3819 2 patients patient NNS cord-015306-us58wwmp 3819 3 were be VBD cord-015306-us58wwmp 3819 4 administered administer VBN cord-015306-us58wwmp 3819 5 CNI CNI NNP cord-015306-us58wwmp 3819 6 , , , cord-015306-us58wwmp 3819 7 and and CC cord-015306-us58wwmp 3819 8 2 2 CD cord-015306-us58wwmp 3819 9 patients patient NNS cord-015306-us58wwmp 3819 10 discontinued discontinue VBD cord-015306-us58wwmp 3819 11 corticosteroid corticosteroid NN cord-015306-us58wwmp 3819 12 during during IN cord-015306-us58wwmp 3819 13 the the DT cord-015306-us58wwmp 3819 14 follow follow NN cord-015306-us58wwmp 3819 15 - - HYPH cord-015306-us58wwmp 3819 16 up up NN cord-015306-us58wwmp 3819 17 period period NN cord-015306-us58wwmp 3819 18 . . . cord-015306-us58wwmp 3820 1 Although although IN cord-015306-us58wwmp 3820 2 5 5 CD cord-015306-us58wwmp 3820 3 patients patient NNS cord-015306-us58wwmp 3820 4 had have VBD cord-015306-us58wwmp 3820 5 ultrafiltration ultrafiltration NN cord-015306-us58wwmp 3820 6 failure failure NN cord-015306-us58wwmp 3820 7 at at IN cord-015306-us58wwmp 3820 8 the the DT cord-015306-us58wwmp 3820 9 time time NN cord-015306-us58wwmp 3820 10 of of IN cord-015306-us58wwmp 3820 11 RT RT NNP cord-015306-us58wwmp 3820 12 , , , cord-015306-us58wwmp 3820 13 there there EX cord-015306-us58wwmp 3820 14 was be VBD cord-015306-us58wwmp 3820 15 no no DT cord-015306-us58wwmp 3820 16 case case NN cord-015306-us58wwmp 3820 17 who who WP cord-015306-us58wwmp 3820 18 developed develop VBD cord-015306-us58wwmp 3820 19 post post JJ cord-015306-us58wwmp 3820 20 - - JJ cord-015306-us58wwmp 3820 21 transplant transplant JJ cord-015306-us58wwmp 3820 22 EPS eps NN cord-015306-us58wwmp 3820 23 . . . cord-015306-us58wwmp 3821 1 Conclusion conclusion NN cord-015306-us58wwmp 3821 2 : : : cord-015306-us58wwmp 3822 1 The the DT cord-015306-us58wwmp 3822 2 case case NN cord-015306-us58wwmp 3822 3 of of IN cord-015306-us58wwmp 3822 4 EPS EPS NNP cord-015306-us58wwmp 3822 5 after after IN cord-015306-us58wwmp 3822 6 RT RT NNP cord-015306-us58wwmp 3822 7 was be VBD cord-015306-us58wwmp 3822 8 not not RB cord-015306-us58wwmp 3822 9 seen see VBN cord-015306-us58wwmp 3822 10 in in IN cord-015306-us58wwmp 3822 11 this this DT cord-015306-us58wwmp 3822 12 study study NN cord-015306-us58wwmp 3822 13 . . . cord-015306-us58wwmp 3823 1 Possible possible JJ cord-015306-us58wwmp 3823 2 explanation explanation NN cord-015306-us58wwmp 3823 3 of of IN cord-015306-us58wwmp 3823 4 this this DT cord-015306-us58wwmp 3823 5 result result NN cord-015306-us58wwmp 3823 6 might may MD cord-015306-us58wwmp 3823 7 be be VB cord-015306-us58wwmp 3823 8 associated associate VBN cord-015306-us58wwmp 3823 9 with with IN cord-015306-us58wwmp 3823 10 shorter short JJR cord-015306-us58wwmp 3823 11 durations duration NNS cord-015306-us58wwmp 3823 12 of of IN cord-015306-us58wwmp 3823 13 PD PD NNP cord-015306-us58wwmp 3823 14 and and CC cord-015306-us58wwmp 3823 15 small small JJ cord-015306-us58wwmp 3823 16 sample sample NN cord-015306-us58wwmp 3823 17 size size NN cord-015306-us58wwmp 3823 18 . . . cord-015306-us58wwmp 3824 1 Since since IN cord-015306-us58wwmp 3824 2 post post JJ cord-015306-us58wwmp 3824 3 - - JJ cord-015306-us58wwmp 3824 4 transplant transplant NN cord-015306-us58wwmp 3824 5 EPS eps NN cord-015306-us58wwmp 3824 6 is be VBZ cord-015306-us58wwmp 3824 7 rare rare JJ cord-015306-us58wwmp 3824 8 but but CC cord-015306-us58wwmp 3824 9 carries carry VBZ cord-015306-us58wwmp 3824 10 a a DT cord-015306-us58wwmp 3824 11 high high JJ cord-015306-us58wwmp 3824 12 mortality mortality NN cord-015306-us58wwmp 3824 13 , , , cord-015306-us58wwmp 3824 14 caution caution NN cord-015306-us58wwmp 3824 15 should should MD cord-015306-us58wwmp 3824 16 be be VB cord-015306-us58wwmp 3824 17 paid pay VBN cord-015306-us58wwmp 3824 18 to to IN cord-015306-us58wwmp 3824 19 developing develop VBG cord-015306-us58wwmp 3824 20 post post JJ cord-015306-us58wwmp 3824 21 - - JJ cord-015306-us58wwmp 3824 22 transplant transplant JJ cord-015306-us58wwmp 3824 23 EPS eps NN cord-015306-us58wwmp 3824 24 even even RB cord-015306-us58wwmp 3824 25 in in IN cord-015306-us58wwmp 3824 26 pediatric pediatric JJ cord-015306-us58wwmp 3824 27 patients patient NNS cord-015306-us58wwmp 3824 28 with with IN cord-015306-us58wwmp 3824 29 a a DT cord-015306-us58wwmp 3824 30 relatively relatively RB cord-015306-us58wwmp 3824 31 long long JJ cord-015306-us58wwmp 3824 32 pre pre JJ cord-015306-us58wwmp 3824 33 - - JJ cord-015306-us58wwmp 3824 34 transplant transplant JJ cord-015306-us58wwmp 3824 35 duration duration NN cord-015306-us58wwmp 3824 36 of of IN cord-015306-us58wwmp 3824 37 PD PD NNP cord-015306-us58wwmp 3824 38 . . . cord-015306-us58wwmp 3825 1 Asli Asli NNP cord-015306-us58wwmp 3825 2 Kantar Kantar NNP cord-015306-us58wwmp 3825 3 , , , cord-015306-us58wwmp 3825 4 Kaan Kaan NNP cord-015306-us58wwmp 3825 5 Gulleroglu Gulleroglu NNP cord-015306-us58wwmp 3825 6 , , , cord-015306-us58wwmp 3825 7 Esra Esra NNP cord-015306-us58wwmp 3825 8 Baskin Baskin NNP cord-015306-us58wwmp 3825 9 , , , cord-015306-us58wwmp 3825 10 Umut Umut NNP cord-015306-us58wwmp 3825 11 Bayrakci Bayrakci NNP cord-015306-us58wwmp 3825 12 , , , cord-015306-us58wwmp 3825 13 Zafer Zafer NNP cord-015306-us58wwmp 3825 14 Ecevit Ecevit NNP cord-015306-us58wwmp 3825 15 , , , cord-015306-us58wwmp 3825 16 Hande Hande NNP cord-015306-us58wwmp 3825 17 Arslan Arslan NNP cord-015306-us58wwmp 3825 18 , , , cord-015306-us58wwmp 3825 19 Aydincan Aydincan NNP cord-015306-us58wwmp 3825 20 Akdur Akdur NNP cord-015306-us58wwmp 3825 21 , , , cord-015306-us58wwmp 3825 22 Gokhan Gokhan NNP cord-015306-us58wwmp 3825 23 Moray Moray NNP cord-015306-us58wwmp 3825 24 , , , cord-015306-us58wwmp 3825 25 Mehmet Mehmet NNP cord-015306-us58wwmp 3825 26 Haberal Haberal NNP cord-015306-us58wwmp 3825 27 Pediatric Pediatric NNP cord-015306-us58wwmp 3825 28 Nephrology Nephrology NNP cord-015306-us58wwmp 3825 29 , , , cord-015306-us58wwmp 3825 30 Baskent Baskent NNP cord-015306-us58wwmp 3825 31 University University NNP cord-015306-us58wwmp 3825 32 , , , cord-015306-us58wwmp 3825 33 Ankara Ankara NNP cord-015306-us58wwmp 3825 34 , , , cord-015306-us58wwmp 3826 1 Turkey Turkey NNP cord-015306-us58wwmp 3826 2 Objective Objective NNP cord-015306-us58wwmp 3826 3 : : : cord-015306-us58wwmp 3827 1 Viral viral JJ cord-015306-us58wwmp 3827 2 infections infection NNS cord-015306-us58wwmp 3827 3 remain remain VBP cord-015306-us58wwmp 3827 4 a a DT cord-015306-us58wwmp 3827 5 significant significant JJ cord-015306-us58wwmp 3827 6 cause cause NN cord-015306-us58wwmp 3827 7 of of IN cord-015306-us58wwmp 3827 8 morbidity morbidity NN cord-015306-us58wwmp 3827 9 and and CC cord-015306-us58wwmp 3827 10 mortality mortality NN cord-015306-us58wwmp 3827 11 following follow VBG cord-015306-us58wwmp 3827 12 renal renal JJ cord-015306-us58wwmp 3827 13 transplantation transplantation NN cord-015306-us58wwmp 3827 14 . . . cord-015306-us58wwmp 3828 1 Although although IN cord-015306-us58wwmp 3828 2 cytomegalovirus cytomegalovirus NNP cord-015306-us58wwmp 3828 3 is be VBZ cord-015306-us58wwmp 3828 4 the the DT cord-015306-us58wwmp 3828 5 most most RBS cord-015306-us58wwmp 3828 6 common common JJ cord-015306-us58wwmp 3828 7 opportunisticpathogenesis opportunisticpathogenesis NN cord-015306-us58wwmp 3828 8 in in IN cord-015306-us58wwmp 3828 9 transplant transplant NN cord-015306-us58wwmp 3828 10 recipients recipient NNS cord-015306-us58wwmp 3828 11 , , , cord-015306-us58wwmp 3828 12 numerous numerous JJ cord-015306-us58wwmp 3828 13 other other JJ cord-015306-us58wwmp 3828 14 viruses virus NNS cord-015306-us58wwmp 3828 15 may may MD cord-015306-us58wwmp 3828 16 affect affect VB cord-015306-us58wwmp 3828 17 clinical clinical JJ cord-015306-us58wwmp 3828 18 outcome outcome NN cord-015306-us58wwmp 3828 19 . . . cord-015306-us58wwmp 3829 1 Viral viral JJ cord-015306-us58wwmp 3829 2 infections infection NNS cord-015306-us58wwmp 3829 3 are be VBP cord-015306-us58wwmp 3829 4 potentially potentially RB cord-015306-us58wwmp 3829 5 severe severe JJ cord-015306-us58wwmp 3829 6 complications complication NNS cord-015306-us58wwmp 3829 7 of of IN cord-015306-us58wwmp 3829 8 transplantation transplantation NN cord-015306-us58wwmp 3829 9 , , , cord-015306-us58wwmp 3829 10 as as IN cord-015306-us58wwmp 3829 11 they -PRON- PRP cord-015306-us58wwmp 3829 12 not not RB cord-015306-us58wwmp 3829 13 only only RB cord-015306-us58wwmp 3829 14 induce induce VBP cord-015306-us58wwmp 3829 15 specific specific JJ cord-015306-us58wwmp 3829 16 diseases disease NNS cord-015306-us58wwmp 3829 17 , , , cord-015306-us58wwmp 3829 18 but but CC cord-015306-us58wwmp 3829 19 they -PRON- PRP cord-015306-us58wwmp 3829 20 also also RB cord-015306-us58wwmp 3829 21 favor favor VBP cord-015306-us58wwmp 3829 22 the the DT cord-015306-us58wwmp 3829 23 development development NN cord-015306-us58wwmp 3829 24 of of IN cord-015306-us58wwmp 3829 25 allograft allograft NN cord-015306-us58wwmp 3829 26 damage damage NN cord-015306-us58wwmp 3829 27 , , , cord-015306-us58wwmp 3829 28 opportunistic opportunistic JJ cord-015306-us58wwmp 3829 29 infections infection NNS cord-015306-us58wwmp 3829 30 and and CC cord-015306-us58wwmp 3829 31 acute acute JJ cord-015306-us58wwmp 3829 32 rejection rejection NN cord-015306-us58wwmp 3829 33 . . . cord-015306-us58wwmp 3830 1 We -PRON- PRP cord-015306-us58wwmp 3830 2 evaluated evaluate VBD cord-015306-us58wwmp 3830 3 the the DT cord-015306-us58wwmp 3830 4 major major JJ cord-015306-us58wwmp 3830 5 viral viral JJ cord-015306-us58wwmp 3830 6 infections infection NNS cord-015306-us58wwmp 3830 7 seen see VBN cord-015306-us58wwmp 3830 8 following follow VBG cord-015306-us58wwmp 3830 9 kidney kidney NN cord-015306-us58wwmp 3830 10 transplantation transplantation NN cord-015306-us58wwmp 3830 11 and and CC cord-015306-us58wwmp 3830 12 allograft allograft NN cord-015306-us58wwmp 3830 13 outcomes outcome NNS cord-015306-us58wwmp 3830 14 in in IN cord-015306-us58wwmp 3830 15 our -PRON- PRP$ cord-015306-us58wwmp 3830 16 pediatric pediatric JJ cord-015306-us58wwmp 3830 17 patients patient NNS cord-015306-us58wwmp 3830 18 . . . cord-015306-us58wwmp 3831 1 Methods method NNS cord-015306-us58wwmp 3831 2 : : : cord-015306-us58wwmp 3832 1 We -PRON- PRP cord-015306-us58wwmp 3832 2 evaluated evaluate VBD cord-015306-us58wwmp 3832 3 retrospectively retrospectively RB cord-015306-us58wwmp 3832 4 94 94 CD cord-015306-us58wwmp 3832 5 pediatric pediatric JJ cord-015306-us58wwmp 3832 6 renal renal JJ cord-015306-us58wwmp 3832 7 transplant transplant NN cord-015306-us58wwmp 3832 8 recipients recipient NNS cord-015306-us58wwmp 3832 9 for for IN cord-015306-us58wwmp 3832 10 the the DT cord-015306-us58wwmp 3832 11 occurrence occurrence NN cord-015306-us58wwmp 3832 12 of of IN cord-015306-us58wwmp 3832 13 viral viral JJ cord-015306-us58wwmp 3832 14 infections infection NNS cord-015306-us58wwmp 3832 15 and and CC cord-015306-us58wwmp 3832 16 compared compare VBN cord-015306-us58wwmp 3832 17 outcomes outcome NNS cord-015306-us58wwmp 3832 18 among among IN cord-015306-us58wwmp 3832 19 these these DT cord-015306-us58wwmp 3832 20 patients patient NNS cord-015306-us58wwmp 3832 21 . . . cord-015306-us58wwmp 3833 1 Patients patient NNS cord-015306-us58wwmp 3833 2 were be VBD cord-015306-us58wwmp 3833 3 divided divide VBN cord-015306-us58wwmp 3833 4 in in IN cord-015306-us58wwmp 3833 5 to to IN cord-015306-us58wwmp 3833 6 two two CD cord-015306-us58wwmp 3833 7 groups group NNS cord-015306-us58wwmp 3833 8 those those DT cord-015306-us58wwmp 3833 9 who who WP cord-015306-us58wwmp 3833 10 developed develop VBD cord-015306-us58wwmp 3833 11 an an DT cord-015306-us58wwmp 3833 12 infection infection NN cord-015306-us58wwmp 3833 13 and and CC cord-015306-us58wwmp 3833 14 those those DT cord-015306-us58wwmp 3833 15 who who WP cord-015306-us58wwmp 3833 16 did do VBD cord-015306-us58wwmp 3833 17 not not RB cord-015306-us58wwmp 3833 18 . . . cord-015306-us58wwmp 3834 1 Inthese inthese JJ cord-015306-us58wwmp 3834 2 groups group NNS cord-015306-us58wwmp 3834 3 , , , cord-015306-us58wwmp 3834 4 we -PRON- PRP cord-015306-us58wwmp 3834 5 recorded record VBD cord-015306-us58wwmp 3834 6 induction induction NN cord-015306-us58wwmp 3834 7 therapy therapy NN cord-015306-us58wwmp 3834 8 used use VBN cord-015306-us58wwmp 3834 9 at at IN cord-015306-us58wwmp 3834 10 transplantation transplantation NN cord-015306-us58wwmp 3834 11 , , , cord-015306-us58wwmp 3834 12 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 3834 13 therapy therapy NN cord-015306-us58wwmp 3834 14 given give VBN cord-015306-us58wwmp 3834 15 at at IN cord-015306-us58wwmp 3834 16 discharge discharge NN cord-015306-us58wwmp 3834 17 , , , cord-015306-us58wwmp 3834 18 acute acute JJ cord-015306-us58wwmp 3834 19 rejection rejection NN cord-015306-us58wwmp 3834 20 rate rate NN cord-015306-us58wwmp 3834 21 , , , cord-015306-us58wwmp 3834 22 patient patient JJ cord-015306-us58wwmp 3834 23 and and CC cord-015306-us58wwmp 3834 24 graft graft NN cord-015306-us58wwmp 3834 25 survival survival NN cord-015306-us58wwmp 3834 26 rates rate NNS cord-015306-us58wwmp 3834 27 . . . cord-015306-us58wwmp 3835 1 Results result NNS cord-015306-us58wwmp 3835 2 : : : cord-015306-us58wwmp 3836 1 The the DT cord-015306-us58wwmp 3836 2 mean mean JJ cord-015306-us58wwmp 3836 3 age age NN cord-015306-us58wwmp 3836 4 of of IN cord-015306-us58wwmp 3836 5 the the DT cord-015306-us58wwmp 3836 6 patients patient NNS cord-015306-us58wwmp 3836 7 was15.5±5.3 was15.5±5.3 XX cord-015306-us58wwmp 3836 8 years year NNS cord-015306-us58wwmp 3836 9 . . . cord-015306-us58wwmp 3837 1 Viral viral JJ cord-015306-us58wwmp 3837 2 infection infection NN cord-015306-us58wwmp 3837 3 was be VBD cord-015306-us58wwmp 3837 4 found find VBN cord-015306-us58wwmp 3837 5 in in IN cord-015306-us58wwmp 3837 6 32 32 CD cord-015306-us58wwmp 3837 7 patients patient NNS cord-015306-us58wwmp 3837 8 . . . cord-015306-us58wwmp 3838 1 Cytomegalovirus Cytomegalovirus NNP cord-015306-us58wwmp 3838 2 infections infection NNS cord-015306-us58wwmp 3838 3 were be VBD cord-015306-us58wwmp 3838 4 the the DT cord-015306-us58wwmp 3838 5 leading lead VBG cord-015306-us58wwmp 3838 6 causes cause NNS cord-015306-us58wwmp 3838 7 ; ; : cord-015306-us58wwmp 3838 8 EBV EBV NNP cord-015306-us58wwmp 3838 9 and and CC cord-015306-us58wwmp 3838 10 BK BK NNP cord-015306-us58wwmp 3838 11 virus virus NN cord-015306-us58wwmp 3838 12 were be VBD cord-015306-us58wwmp 3838 13 following follow VBG cord-015306-us58wwmp 3838 14 causes cause NNS cord-015306-us58wwmp 3838 15 in in IN cord-015306-us58wwmp 3838 16 our -PRON- PRP$ cord-015306-us58wwmp 3838 17 study study NN cord-015306-us58wwmp 3838 18 . . . cord-015306-us58wwmp 3839 1 Any any DT cord-015306-us58wwmp 3839 2 significant significant JJ cord-015306-us58wwmp 3839 3 correlation correlation NN cord-015306-us58wwmp 3839 4 could could MD cord-015306-us58wwmp 3839 5 not not RB cord-015306-us58wwmp 3839 6 be be VB cord-015306-us58wwmp 3839 7 shown show VBN cord-015306-us58wwmp 3839 8 between between IN cord-015306-us58wwmp 3839 9 viral viral JJ cord-015306-us58wwmp 3839 10 infections infection NNS cord-015306-us58wwmp 3839 11 and and CC cord-015306-us58wwmp 3839 12 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 3839 13 therapy therapy NN cord-015306-us58wwmp 3839 14 . . . cord-015306-us58wwmp 3840 1 We -PRON- PRP cord-015306-us58wwmp 3840 2 did do VBD cord-015306-us58wwmp 3840 3 not not RB cord-015306-us58wwmp 3840 4 observe observe VB cord-015306-us58wwmp 3840 5 any any DT cord-015306-us58wwmp 3840 6 correlation correlation NN cord-015306-us58wwmp 3840 7 between between IN cord-015306-us58wwmp 3840 8 acute acute JJ cord-015306-us58wwmp 3840 9 rejection rejection NN cord-015306-us58wwmp 3840 10 and and CC cord-015306-us58wwmp 3840 11 viral viral JJ cord-015306-us58wwmp 3840 12 infections infection NNS cord-015306-us58wwmp 3840 13 . . . cord-015306-us58wwmp 3841 1 Lowest low JJS cord-015306-us58wwmp 3841 2 GFR GFR NNP cord-015306-us58wwmp 3841 3 at at IN cord-015306-us58wwmp 3841 4 6 6 CD cord-015306-us58wwmp 3841 5 th th XX cord-015306-us58wwmp 3841 6 month month NN cord-015306-us58wwmp 3841 7 was be VBD cord-015306-us58wwmp 3841 8 shown show VBN cord-015306-us58wwmp 3841 9 in in IN cord-015306-us58wwmp 3841 10 patients patient NNS cord-015306-us58wwmp 3841 11 with with IN cord-015306-us58wwmp 3841 12 BK BK NNP cord-015306-us58wwmp 3841 13 virus virus NN cord-015306-us58wwmp 3841 14 infection infection NN cord-015306-us58wwmp 3841 15 . . . cord-015306-us58wwmp 3842 1 A a DT cord-015306-us58wwmp 3842 2 significant significant JJ cord-015306-us58wwmp 3842 3 correlation correlation NN cord-015306-us58wwmp 3842 4 was be VBD cord-015306-us58wwmp 3842 5 shown show VBN cord-015306-us58wwmp 3842 6 between between IN cord-015306-us58wwmp 3842 7 viral viral JJ cord-015306-us58wwmp 3842 8 infection infection NN cord-015306-us58wwmp 3842 9 and and CC cord-015306-us58wwmp 3842 10 graftloss graftloss NNP cord-015306-us58wwmp 3842 11 ( ( -LRB- cord-015306-us58wwmp 3842 12 r r NN cord-015306-us58wwmp 3842 13 : : : cord-015306-us58wwmp 3842 14 0.22 0.22 CD cord-015306-us58wwmp 3842 15 p p NN cord-015306-us58wwmp 3842 16 : : : cord-015306-us58wwmp 3842 17 0.028 0.028 CD cord-015306-us58wwmp 3842 18 ) ) -RRB- cord-015306-us58wwmp 3842 19 . . . cord-015306-us58wwmp 3843 1 Conclusion conclusion NN cord-015306-us58wwmp 3843 2 : : : cord-015306-us58wwmp 3844 1 Viral viral JJ cord-015306-us58wwmp 3844 2 infections infection NNS cord-015306-us58wwmp 3844 3 are be VBP cord-015306-us58wwmp 3844 4 common common JJ cord-015306-us58wwmp 3844 5 after after IN cord-015306-us58wwmp 3844 6 kidney kidney NN cord-015306-us58wwmp 3844 7 transplantation transplantation NN cord-015306-us58wwmp 3844 8 . . . cord-015306-us58wwmp 3845 1 Patients patient NNS cord-015306-us58wwmp 3845 2 should should MD cord-015306-us58wwmp 3845 3 be be VB cord-015306-us58wwmp 3845 4 monitored monitor VBN cord-015306-us58wwmp 3845 5 more more RBR cord-015306-us58wwmp 3845 6 carefully carefully RB cord-015306-us58wwmp 3845 7 for for IN cord-015306-us58wwmp 3845 8 provide provide VB cord-015306-us58wwmp 3845 9 against against IN cord-015306-us58wwmp 3845 10 damage damage NN cord-015306-us58wwmp 3845 11 in in IN cord-015306-us58wwmp 3845 12 transplanted transplant VBN cord-015306-us58wwmp 3845 13 kidney kidney NN cord-015306-us58wwmp 3845 14 . . . cord-015306-us58wwmp 3846 1 Objective objective NN cord-015306-us58wwmp 3846 2 : : : cord-015306-us58wwmp 3847 1 Anemia anemia NN cord-015306-us58wwmp 3847 2 is be VBZ cord-015306-us58wwmp 3847 3 a a DT cord-015306-us58wwmp 3847 4 frequent frequent JJ cord-015306-us58wwmp 3847 5 condition condition NN cord-015306-us58wwmp 3847 6 in in IN cord-015306-us58wwmp 3847 7 kidney kidney NN cord-015306-us58wwmp 3847 8 transplant transplant NN cord-015306-us58wwmp 3847 9 recipients recipient NNS cord-015306-us58wwmp 3847 10 and and CC cord-015306-us58wwmp 3847 11 it -PRON- PRP cord-015306-us58wwmp 3847 12 has have VBZ cord-015306-us58wwmp 3847 13 a a DT cord-015306-us58wwmp 3847 14 negative negative JJ cord-015306-us58wwmp 3847 15 long long JJ cord-015306-us58wwmp 3847 16 term term NN cord-015306-us58wwmp 3847 17 impact impact NN cord-015306-us58wwmp 3847 18 on on IN cord-015306-us58wwmp 3847 19 graft graft NN cord-015306-us58wwmp 3847 20 and and CC cord-015306-us58wwmp 3847 21 patient patient JJ cord-015306-us58wwmp 3847 22 outcomes outcome NNS cord-015306-us58wwmp 3847 23 . . . cord-015306-us58wwmp 3848 1 Recently recently RB cord-015306-us58wwmp 3848 2 it -PRON- PRP cord-015306-us58wwmp 3848 3 has have VBZ cord-015306-us58wwmp 3848 4 been be VBN cord-015306-us58wwmp 3848 5 shown show VBN cord-015306-us58wwmp 3848 6 that that DT cord-015306-us58wwmp 3848 7 treatment treatment NN cord-015306-us58wwmp 3848 8 with with IN cord-015306-us58wwmp 3848 9 angiotensinconverting angiotensinconverte VBG cord-015306-us58wwmp 3848 10 enzyme enzyme NN cord-015306-us58wwmp 3848 11 inhibitors inhibitor NNS cord-015306-us58wwmp 3848 12 ( ( -LRB- cord-015306-us58wwmp 3848 13 ACEI ACEI NNP cord-015306-us58wwmp 3848 14 ) ) -RRB- cord-015306-us58wwmp 3848 15 , , , cord-015306-us58wwmp 3848 16 angiotensin angiotensin NN cord-015306-us58wwmp 3848 17 II ii CD cord-015306-us58wwmp 3848 18 receptor receptor NN cord-015306-us58wwmp 3848 19 blockers blocker NNS cord-015306-us58wwmp 3848 20 ( ( -LRB- cord-015306-us58wwmp 3848 21 ARB ARB NNP cord-015306-us58wwmp 3848 22 ) ) -RRB- cord-015306-us58wwmp 3848 23 and and CC cord-015306-us58wwmp 3848 24 mTOR mTOR NNP cord-015306-us58wwmp 3848 25 inhibitors inhibitor NNS cord-015306-us58wwmp 3848 26 could could MD cord-015306-us58wwmp 3848 27 be be VB cord-015306-us58wwmp 3848 28 the the DT cord-015306-us58wwmp 3848 29 leading lead VBG cord-015306-us58wwmp 3848 30 causes cause NNS cord-015306-us58wwmp 3848 31 of of IN cord-015306-us58wwmp 3848 32 anemia anemia NN cord-015306-us58wwmp 3848 33 in in IN cord-015306-us58wwmp 3848 34 renal renal JJ cord-015306-us58wwmp 3848 35 transplant transplant NN cord-015306-us58wwmp 3848 36 recipients recipient NNS cord-015306-us58wwmp 3848 37 . . . cord-015306-us58wwmp 3849 1 To to TO cord-015306-us58wwmp 3849 2 study study VB cord-015306-us58wwmp 3849 3 the the DT cord-015306-us58wwmp 3849 4 association association NN cord-015306-us58wwmp 3849 5 of of IN cord-015306-us58wwmp 3849 6 hemoglobin hemoglobin NNP cord-015306-us58wwmp 3849 7 ( ( -LRB- cord-015306-us58wwmp 3849 8 Hb Hb NNP cord-015306-us58wwmp 3849 9 ) ) -RRB- cord-015306-us58wwmp 3849 10 and and CC cord-015306-us58wwmp 3849 11 ferric ferric JJ cord-015306-us58wwmp 3849 12 parameters parameter NNS cord-015306-us58wwmp 3849 13 with with IN cord-015306-us58wwmp 3849 14 GFR GFR NNP cord-015306-us58wwmp 3849 15 , , , cord-015306-us58wwmp 3849 16 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 3849 17 drugs drug NNS cord-015306-us58wwmp 3849 18 , , , cord-015306-us58wwmp 3849 19 ACEI ACEI NNP cord-015306-us58wwmp 3849 20 , , , cord-015306-us58wwmp 3849 21 ARB ARB NNP cord-015306-us58wwmp 3849 22 and and CC cord-015306-us58wwmp 3849 23 clinical clinical JJ cord-015306-us58wwmp 3849 24 features feature NNS cord-015306-us58wwmp 3849 25 of of IN cord-015306-us58wwmp 3849 26 kidney kidney NN cord-015306-us58wwmp 3849 27 recipients recipient NNS cord-015306-us58wwmp 3849 28 . . . cord-015306-us58wwmp 3850 1 Method method NN cord-015306-us58wwmp 3850 2 : : : cord-015306-us58wwmp 3850 3 Hospital hospital NN cord-015306-us58wwmp 3850 4 records record NNS cord-015306-us58wwmp 3850 5 of of IN cord-015306-us58wwmp 3850 6 94 94 CD cord-015306-us58wwmp 3850 7 ( ( -LRB- cord-015306-us58wwmp 3850 8 F F NNP cord-015306-us58wwmp 3850 9 / / SYM cord-015306-us58wwmp 3850 10 M:48/46 M:48/46 NNP cord-015306-us58wwmp 3850 11 ) ) -RRB- cord-015306-us58wwmp 3851 1 kidney kidney NN cord-015306-us58wwmp 3851 2 recipients recipient NNS cord-015306-us58wwmp 3851 3 were be VBD cord-015306-us58wwmp 3851 4 reviewed review VBN cord-015306-us58wwmp 3851 5 retrospectively retrospectively RB cord-015306-us58wwmp 3851 6 . . . cord-015306-us58wwmp 3852 1 The the DT cord-015306-us58wwmp 3852 2 mean mean JJ cord-015306-us58wwmp 3852 3 age age NN cord-015306-us58wwmp 3852 4 of of IN cord-015306-us58wwmp 3852 5 the the DT cord-015306-us58wwmp 3852 6 study study NN cord-015306-us58wwmp 3852 7 group group NN cord-015306-us58wwmp 3852 8 was be VBD cord-015306-us58wwmp 3852 9 15.5±5.3 15.5±5.3 CD cord-015306-us58wwmp 3852 10 years year NNS cord-015306-us58wwmp 3852 11 . . . cord-015306-us58wwmp 3853 1 The the DT cord-015306-us58wwmp 3853 2 mean mean JJ cord-015306-us58wwmp 3853 3 follow follow NN cord-015306-us58wwmp 3853 4 - - HYPH cord-015306-us58wwmp 3853 5 up up NN cord-015306-us58wwmp 3853 6 was be VBD cord-015306-us58wwmp 3853 7 52.6±36.31 52.6±36.31 CD cord-015306-us58wwmp 3853 8 months month NNS cord-015306-us58wwmp 3853 9 . . . cord-015306-us58wwmp 3854 1 Results result NNS cord-015306-us58wwmp 3854 2 : : : cord-015306-us58wwmp 3855 1 Thirty thirty CD cord-015306-us58wwmp 3855 2 six six CD cord-015306-us58wwmp 3855 3 ( ( -LRB- cord-015306-us58wwmp 3855 4 38 38 CD cord-015306-us58wwmp 3855 5 % % NN cord-015306-us58wwmp 3855 6 ) ) -RRB- cord-015306-us58wwmp 3856 1 patients patient NNS cord-015306-us58wwmp 3856 2 were be VBD cord-015306-us58wwmp 3856 3 found find VBN cord-015306-us58wwmp 3856 4 to to TO cord-015306-us58wwmp 3856 5 be be VB cord-015306-us58wwmp 3856 6 anemic anemic JJ cord-015306-us58wwmp 3856 7 . . . cord-015306-us58wwmp 3857 1 Mean mean JJ cord-015306-us58wwmp 3857 2 Hb Hb NNP cord-015306-us58wwmp 3857 3 levels level NNS cord-015306-us58wwmp 3857 4 of of IN cord-015306-us58wwmp 3857 5 anemic anemic JJ cord-015306-us58wwmp 3857 6 and and CC cord-015306-us58wwmp 3857 7 non non JJ cord-015306-us58wwmp 3857 8 anemic anemic JJ cord-015306-us58wwmp 3857 9 patients patient NNS cord-015306-us58wwmp 3857 10 were be VBD cord-015306-us58wwmp 3858 1 10.2±1.15 10.2±1.15 CD cord-015306-us58wwmp 3858 2 mg mg NNP cord-015306-us58wwmp 3858 3 / / SYM cord-015306-us58wwmp 3858 4 dl dl NNP cord-015306-us58wwmp 3858 5 vs vs IN cord-015306-us58wwmp 3858 6 13.87±3.41 13.87±3.41 CD cord-015306-us58wwmp 3858 7 mg mg NNP cord-015306-us58wwmp 3858 8 / / SYM cord-015306-us58wwmp 3858 9 dl dl NNP cord-015306-us58wwmp 3858 10 respectively respectively RB cord-015306-us58wwmp 3858 11 . . . cord-015306-us58wwmp 3859 1 Ferritin ferritin NN cord-015306-us58wwmp 3859 2 and and CC cord-015306-us58wwmp 3859 3 iron iron NN cord-015306-us58wwmp 3859 4 levels level NNS cord-015306-us58wwmp 3859 5 as as RB cord-015306-us58wwmp 3859 6 well well RB cord-015306-us58wwmp 3859 7 as as IN cord-015306-us58wwmp 3859 8 transferrin transferrin NN cord-015306-us58wwmp 3859 9 saturation saturation NN cord-015306-us58wwmp 3859 10 index index NN cord-015306-us58wwmp 3859 11 , , , cord-015306-us58wwmp 3859 12 RDW RDW NNP cord-015306-us58wwmp 3859 13 and and CC cord-015306-us58wwmp 3859 14 MCV MCV NNP cord-015306-us58wwmp 3859 15 did do VBD cord-015306-us58wwmp 3859 16 not not RB cord-015306-us58wwmp 3859 17 differ differ VB cord-015306-us58wwmp 3859 18 among among IN cord-015306-us58wwmp 3859 19 the the DT cord-015306-us58wwmp 3859 20 groups group NNS cord-015306-us58wwmp 3859 21 . . . cord-015306-us58wwmp 3860 1 Anemia anemia NN cord-015306-us58wwmp 3860 2 was be VBD cord-015306-us58wwmp 3860 3 not not RB cord-015306-us58wwmp 3860 4 found find VBN cord-015306-us58wwmp 3860 5 to to TO cord-015306-us58wwmp 3860 6 be be VB cord-015306-us58wwmp 3860 7 correlated correlate VBN cord-015306-us58wwmp 3860 8 with with IN cord-015306-us58wwmp 3860 9 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 3860 10 or or CC cord-015306-us58wwmp 3860 11 antihypertensive antihypertensive JJ cord-015306-us58wwmp 3860 12 drugs drug NNS cord-015306-us58wwmp 3860 13 including include VBG cord-015306-us58wwmp 3860 14 ACEI ACEI NNP cord-015306-us58wwmp 3860 15 and and CC cord-015306-us58wwmp 3860 16 ARB ARB NNP cord-015306-us58wwmp 3860 17 . . . cord-015306-us58wwmp 3861 1 Donor donor NN cord-015306-us58wwmp 3861 2 status status NN cord-015306-us58wwmp 3861 3 did do VBD cord-015306-us58wwmp 3861 4 not not RB cord-015306-us58wwmp 3861 5 also also RB cord-015306-us58wwmp 3861 6 have have VB cord-015306-us58wwmp 3861 7 any any DT cord-015306-us58wwmp 3861 8 influence influence NN cord-015306-us58wwmp 3861 9 on on IN cord-015306-us58wwmp 3861 10 anemia anemia NN cord-015306-us58wwmp 3861 11 . . . cord-015306-us58wwmp 3862 1 Mean mean JJ cord-015306-us58wwmp 3862 2 GFR gfr NN cord-015306-us58wwmp 3862 3 of of IN cord-015306-us58wwmp 3862 4 patients patient NNS cord-015306-us58wwmp 3862 5 at at IN cord-015306-us58wwmp 3862 6 posttransplant posttransplant NN cord-015306-us58wwmp 3862 7 6 6 CD cord-015306-us58wwmp 3862 8 months month NNS cord-015306-us58wwmp 3862 9 and and CC cord-015306-us58wwmp 3862 10 1 1 CD cord-015306-us58wwmp 3862 11 year year NN cord-015306-us58wwmp 3862 12 follow follow NN cord-015306-us58wwmp 3862 13 - - HYPH cord-015306-us58wwmp 3862 14 up up NN cord-015306-us58wwmp 3862 15 was be VBD cord-015306-us58wwmp 3862 16 found find VBN cord-015306-us58wwmp 3862 17 to to TO cord-015306-us58wwmp 3862 18 be be VB cord-015306-us58wwmp 3862 19 significantly significantly RB cord-015306-us58wwmp 3862 20 lover lover NN cord-015306-us58wwmp 3862 21 than than IN cord-015306-us58wwmp 3862 22 patients patient NNS cord-015306-us58wwmp 3862 23 without without IN cord-015306-us58wwmp 3862 24 anemia anemia NN cord-015306-us58wwmp 3862 25 ( ( -LRB- cord-015306-us58wwmp 3862 26 74.4±34.1 74.4±34.1 CD cord-015306-us58wwmp 3862 27 vs vs IN cord-015306-us58wwmp 3862 28 99.1±28.9 99.1±28.9 CD cord-015306-us58wwmp 3862 29 ml ml NN cord-015306-us58wwmp 3862 30 / / SYM cord-015306-us58wwmp 3862 31 min/1.73m2 min/1.73m2 NNP cord-015306-us58wwmp 3862 32 respectively respectively RB cord-015306-us58wwmp 3862 33 ) ) -RRB- cord-015306-us58wwmp 3862 34 . . . cord-015306-us58wwmp 3863 1 Graft graft NN cord-015306-us58wwmp 3863 2 loss loss NN cord-015306-us58wwmp 3863 3 was be VBD cord-015306-us58wwmp 3863 4 also also RB cord-015306-us58wwmp 3863 5 found find VBN cord-015306-us58wwmp 3863 6 to to TO cord-015306-us58wwmp 3863 7 be be VB cord-015306-us58wwmp 3863 8 significantly significantly RB cord-015306-us58wwmp 3863 9 higher high JJR cord-015306-us58wwmp 3863 10 in in IN cord-015306-us58wwmp 3863 11 anemic anemic JJ cord-015306-us58wwmp 3863 12 patients patient NNS cord-015306-us58wwmp 3863 13 ( ( -LRB- cord-015306-us58wwmp 3863 14 16 16 CD cord-015306-us58wwmp 3863 15 % % NN cord-015306-us58wwmp 3863 16 vs vs IN cord-015306-us58wwmp 3863 17 6 6 CD cord-015306-us58wwmp 3863 18 % % NN cord-015306-us58wwmp 3863 19 , , , cord-015306-us58wwmp 3863 20 p<0.018 p<0.018 CD cord-015306-us58wwmp 3863 21 ) ) -RRB- cord-015306-us58wwmp 3863 22 . . . cord-015306-us58wwmp 3864 1 Conclusion conclusion NN cord-015306-us58wwmp 3864 2 : : : cord-015306-us58wwmp 3865 1 In in IN cord-015306-us58wwmp 3865 2 this this DT cord-015306-us58wwmp 3865 3 study study NN cord-015306-us58wwmp 3865 4 we -PRON- PRP cord-015306-us58wwmp 3865 5 examined examine VBD cord-015306-us58wwmp 3865 6 the the DT cord-015306-us58wwmp 3865 7 prevalence prevalence NN cord-015306-us58wwmp 3865 8 of of IN cord-015306-us58wwmp 3865 9 anemia anemia NN cord-015306-us58wwmp 3865 10 and and CC cord-015306-us58wwmp 3865 11 its -PRON- PRP$ cord-015306-us58wwmp 3865 12 risk risk NN cord-015306-us58wwmp 3865 13 factors factor NNS cord-015306-us58wwmp 3865 14 in in IN cord-015306-us58wwmp 3865 15 kidney kidney NN cord-015306-us58wwmp 3865 16 transplanted transplant VBN cord-015306-us58wwmp 3865 17 patients patient NNS cord-015306-us58wwmp 3865 18 . . . cord-015306-us58wwmp 3866 1 Its -PRON- PRP$ cord-015306-us58wwmp 3866 2 incidence incidence NN cord-015306-us58wwmp 3866 3 is be VBZ cord-015306-us58wwmp 3866 4 quite quite RB cord-015306-us58wwmp 3866 5 high high JJ cord-015306-us58wwmp 3866 6 in in IN cord-015306-us58wwmp 3866 7 our -PRON- PRP$ cord-015306-us58wwmp 3866 8 patients patient NNS cord-015306-us58wwmp 3866 9 . . . cord-015306-us58wwmp 3867 1 We -PRON- PRP cord-015306-us58wwmp 3867 2 found find VBD cord-015306-us58wwmp 3867 3 that that DT cord-015306-us58wwmp 3867 4 anemia anemia NN cord-015306-us58wwmp 3867 5 in in IN cord-015306-us58wwmp 3867 6 kidney kidney NN cord-015306-us58wwmp 3867 7 recipients recipient NNS cord-015306-us58wwmp 3867 8 is be VBZ cord-015306-us58wwmp 3867 9 neither neither CC cord-015306-us58wwmp 3867 10 related relate VBN cord-015306-us58wwmp 3867 11 to to IN cord-015306-us58wwmp 3867 12 iron iron NN cord-015306-us58wwmp 3867 13 status status NN cord-015306-us58wwmp 3867 14 nor nor CC cord-015306-us58wwmp 3867 15 medications medication NNS cord-015306-us58wwmp 3867 16 like like IN cord-015306-us58wwmp 3867 17 ACEI ACEI NNP cord-015306-us58wwmp 3867 18 , , , cord-015306-us58wwmp 3867 19 ARB ARB NNP cord-015306-us58wwmp 3867 20 or or CC cord-015306-us58wwmp 3867 21 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 3867 22 drugs drug NNS cord-015306-us58wwmp 3867 23 . . . cord-015306-us58wwmp 3868 1 The the DT cord-015306-us58wwmp 3868 2 major major JJ cord-015306-us58wwmp 3868 3 determinant determinant NN cord-015306-us58wwmp 3868 4 of of IN cord-015306-us58wwmp 3868 5 Hb Hb NNP cord-015306-us58wwmp 3868 6 level level NN cord-015306-us58wwmp 3868 7 , , , cord-015306-us58wwmp 3868 8 especially especially RB cord-015306-us58wwmp 3868 9 during during IN cord-015306-us58wwmp 3868 10 the the DT cord-015306-us58wwmp 3868 11 first first JJ cord-015306-us58wwmp 3868 12 year year NN cord-015306-us58wwmp 3868 13 of of IN cord-015306-us58wwmp 3868 14 transplantation transplantation NN cord-015306-us58wwmp 3868 15 is be VBZ cord-015306-us58wwmp 3868 16 the the DT cord-015306-us58wwmp 3868 17 graft graft NN cord-015306-us58wwmp 3868 18 function function NN cord-015306-us58wwmp 3868 19 . . . cord-015306-us58wwmp 3869 1 The the DT cord-015306-us58wwmp 3869 2 most most RBS cord-015306-us58wwmp 3869 3 important important JJ cord-015306-us58wwmp 3869 4 conclusion conclusion NN cord-015306-us58wwmp 3869 5 of of IN cord-015306-us58wwmp 3869 6 this this DT cord-015306-us58wwmp 3869 7 study study NN cord-015306-us58wwmp 3869 8 is be VBZ cord-015306-us58wwmp 3869 9 the the DT cord-015306-us58wwmp 3869 10 considerable considerable JJ cord-015306-us58wwmp 3869 11 controversial controversial JJ cord-015306-us58wwmp 3869 12 impact impact NN cord-015306-us58wwmp 3869 13 of of IN cord-015306-us58wwmp 3869 14 anemia anemia NN cord-015306-us58wwmp 3869 15 on on IN cord-015306-us58wwmp 3869 16 graft graft NN cord-015306-us58wwmp 3869 17 survival survival NN cord-015306-us58wwmp 3869 18 . . . cord-015306-us58wwmp 3870 1 There there EX cord-015306-us58wwmp 3870 2 was be VBD cord-015306-us58wwmp 3870 3 no no DT cord-015306-us58wwmp 3870 4 significant significant JJ cord-015306-us58wwmp 3870 5 effect effect NN cord-015306-us58wwmp 3870 6 on on IN cord-015306-us58wwmp 3870 7 blood blood NN cord-015306-us58wwmp 3870 8 pressure pressure NN cord-015306-us58wwmp 3870 9 ; ; : cord-015306-us58wwmp 3870 10 4 4 CD cord-015306-us58wwmp 3870 11 patients patient NNS cord-015306-us58wwmp 3870 12 7±2 7±2 CD cord-015306-us58wwmp 3871 1 Modigraf Modigraf NNP cord-015306-us58wwmp 3872 1 ® ® NNP cord-015306-us58wwmp 3872 2 administration administration NN cord-015306-us58wwmp 3872 3 days day NNS cord-015306-us58wwmp 3872 4 in in IN cord-015306-us58wwmp 3872 5 the the DT cord-015306-us58wwmp 3872 6 converted converted JJ cord-015306-us58wwmp 3872 7 group group NN cord-015306-us58wwmp 3872 8 . . . cord-015306-us58wwmp 3873 1 In in IN cord-015306-us58wwmp 3873 2 the the DT cord-015306-us58wwmp 3873 3 whole whole JJ cord-015306-us58wwmp 3873 4 series series NN cord-015306-us58wwmp 3873 5 , , , cord-015306-us58wwmp 3873 6 mean mean JJ cord-015306-us58wwmp 3873 7 creatinine creatinine NN cord-015306-us58wwmp 3873 8 level level NN cord-015306-us58wwmp 3873 9 was be VBD cord-015306-us58wwmp 3873 10 0.7±0.5 0.7±0.5 NNP cord-015306-us58wwmp 3873 11 mg mg NNP cord-015306-us58wwmp 3873 12 / / SYM cord-015306-us58wwmp 3873 13 dl dl NNP cord-015306-us58wwmp 3873 14 throughout throughout IN cord-015306-us58wwmp 3873 15 the the DT cord-015306-us58wwmp 3873 16 observational observational JJ cord-015306-us58wwmp 3873 17 period period NN cord-015306-us58wwmp 3873 18 , , , cord-015306-us58wwmp 3873 19 and and CC cord-015306-us58wwmp 3873 20 no no DT cord-015306-us58wwmp 3873 21 rejection rejection NN cord-015306-us58wwmp 3873 22 episodes episode NNS cord-015306-us58wwmp 3873 23 were be VBD cord-015306-us58wwmp 3873 24 detected detect VBN cord-015306-us58wwmp 3873 25 . . . cord-015306-us58wwmp 3874 1 Blood blood NN cord-015306-us58wwmp 3874 2 pressure pressure NN cord-015306-us58wwmp 3874 3 was be VBD cord-015306-us58wwmp 3874 4 well well RB cord-015306-us58wwmp 3874 5 controlled control VBN cord-015306-us58wwmp 3874 6 and and CC cord-015306-us58wwmp 3874 7 no no DT cord-015306-us58wwmp 3874 8 proteinuria proteinuria NN cord-015306-us58wwmp 3874 9 was be VBD cord-015306-us58wwmp 3874 10 seen see VBN cord-015306-us58wwmp 3874 11 . . . cord-015306-us58wwmp 3875 1 The the DT cord-015306-us58wwmp 3875 2 equivalent equivalent JJ cord-015306-us58wwmp 3875 3 dose dose NN cord-015306-us58wwmp 3875 4 ratio ratio NN cord-015306-us58wwmp 3875 5 between between IN cord-015306-us58wwmp 3875 6 Modigraf Modigraf NNP cord-015306-us58wwmp 3875 7 ® ® NN cord-015306-us58wwmp 3875 8 and and CC cord-015306-us58wwmp 3875 9 liquid liquid NN cord-015306-us58wwmp 3875 10 tacrolimus tacrolimus NN cord-015306-us58wwmp 3875 11 was be VBD cord-015306-us58wwmp 3875 12 1.28 1.28 CD cord-015306-us58wwmp 3875 13 . . . cord-015306-us58wwmp 3876 1 Conclusion conclusion NN cord-015306-us58wwmp 3876 2 : : : cord-015306-us58wwmp 3877 1 Modigraf Modigraf NNP cord-015306-us58wwmp 3877 2 ® ® NNP cord-015306-us58wwmp 3877 3 appears appear VBZ cord-015306-us58wwmp 3877 4 to to TO cord-015306-us58wwmp 3877 5 be be VB cord-015306-us58wwmp 3877 6 a a DT cord-015306-us58wwmp 3877 7 safe safe JJ cord-015306-us58wwmp 3877 8 and and CC cord-015306-us58wwmp 3877 9 sustainable sustainable JJ cord-015306-us58wwmp 3877 10 way way NN cord-015306-us58wwmp 3877 11 to to TO cord-015306-us58wwmp 3877 12 administer administer VB cord-015306-us58wwmp 3877 13 tacrolimus tacrolimus NN cord-015306-us58wwmp 3877 14 in in IN cord-015306-us58wwmp 3877 15 kidney kidney NN cord-015306-us58wwmp 3877 16 transplanted transplant VBN cord-015306-us58wwmp 3877 17 infants infant NNS cord-015306-us58wwmp 3877 18 . . . cord-015306-us58wwmp 3878 1 In in IN cord-015306-us58wwmp 3878 2 our -PRON- PRP$ cord-015306-us58wwmp 3878 3 experience experience NN cord-015306-us58wwmp 3878 4 required require VBN cord-015306-us58wwmp 3878 5 Modigraf Modigraf NNP cord-015306-us58wwmp 3879 1 ® ® , cord-015306-us58wwmp 3879 2 dose dose NN cord-015306-us58wwmp 3879 3 was be VBD cord-015306-us58wwmp 3879 4 1.28 1.28 CD cord-015306-us58wwmp 3879 5 times time NNS cord-015306-us58wwmp 3879 6 the the DT cord-015306-us58wwmp 3879 7 oral oral JJ cord-015306-us58wwmp 3879 8 liquid liquid NN cord-015306-us58wwmp 3879 9 tacrolimus tacrolimus NNP cord-015306-us58wwmp 3879 10 one one CD cord-015306-us58wwmp 3879 11 , , , cord-015306-us58wwmp 3879 12 and and CC cord-015306-us58wwmp 3879 13 therapeutic therapeutic JJ cord-015306-us58wwmp 3879 14 levels level NNS cord-015306-us58wwmp 3879 15 were be VBD cord-015306-us58wwmp 3879 16 attained attain VBN cord-015306-us58wwmp 3879 17 in in IN cord-015306-us58wwmp 3879 18 one one CD cord-015306-us58wwmp 3879 19 week week NN cord-015306-us58wwmp 3879 20 . . . cord-015306-us58wwmp 3880 1 Objective objective JJ cord-015306-us58wwmp 3880 2 : : : cord-015306-us58wwmp 3880 3 Prescribing prescribing NN cord-015306-us58wwmp 3880 4 of of IN cord-015306-us58wwmp 3880 5 medications medication NNS cord-015306-us58wwmp 3880 6 in in IN cord-015306-us58wwmp 3880 7 paediatric paediatric JJ cord-015306-us58wwmp 3880 8 practice practice NN cord-015306-us58wwmp 3880 9 is be VBZ cord-015306-us58wwmp 3880 10 problematic problematic JJ cord-015306-us58wwmp 3880 11 as as IN cord-015306-us58wwmp 3880 12 many many JJ cord-015306-us58wwmp 3880 13 drugs drug NNS cord-015306-us58wwmp 3880 14 remain remain VBP cord-015306-us58wwmp 3880 15 unlicensed unlicensed JJ cord-015306-us58wwmp 3880 16 . . . cord-015306-us58wwmp 3881 1 This this DT cord-015306-us58wwmp 3881 2 is be VBZ cord-015306-us58wwmp 3881 3 especially especially RB cord-015306-us58wwmp 3881 4 true true JJ cord-015306-us58wwmp 3881 5 of of IN cord-015306-us58wwmp 3881 6 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 3881 7 medications medication NNS cord-015306-us58wwmp 3881 8 . . . cord-015306-us58wwmp 3882 1 However however RB cord-015306-us58wwmp 3882 2 , , , cord-015306-us58wwmp 3882 3 there there EX cord-015306-us58wwmp 3882 4 is be VBZ cord-015306-us58wwmp 3882 5 now now RB cord-015306-us58wwmp 3882 6 a a DT cord-015306-us58wwmp 3882 7 licensed licensed JJ cord-015306-us58wwmp 3882 8 product product NN cord-015306-us58wwmp 3882 9 for for IN cord-015306-us58wwmp 3882 10 Tacrolimus Tacrolimus NNP cord-015306-us58wwmp 3882 11 called call VBN cord-015306-us58wwmp 3882 12 Modigraf Modigraf NNP cord-015306-us58wwmp 3882 13 ® ® VBP cord-015306-us58wwmp 3882 14 with with IN cord-015306-us58wwmp 3882 15 data datum NNS cord-015306-us58wwmp 3882 16 available available JJ cord-015306-us58wwmp 3882 17 on on IN cord-015306-us58wwmp 3882 18 bioavailability bioavailability NN cord-015306-us58wwmp 3882 19 . . . cord-015306-us58wwmp 3883 1 We -PRON- PRP cord-015306-us58wwmp 3883 2 undertook undertake VBD cord-015306-us58wwmp 3883 3 a a DT cord-015306-us58wwmp 3883 4 single single JJ cord-015306-us58wwmp 3883 5 centre centre NN cord-015306-us58wwmp 3883 6 prospective prospective JJ cord-015306-us58wwmp 3883 7 study study NN cord-015306-us58wwmp 3883 8 of of IN cord-015306-us58wwmp 3883 9 conversion conversion NN cord-015306-us58wwmp 3883 10 to to IN cord-015306-us58wwmp 3883 11 Modigraf Modigraf NNP cord-015306-us58wwmp 3883 12 ® ® NNP cord-015306-us58wwmp 3883 13 , , , cord-015306-us58wwmp 3883 14 an an DT cord-015306-us58wwmp 3883 15 oral oral JJ cord-015306-us58wwmp 3883 16 liquid liquid NN cord-015306-us58wwmp 3883 17 available available JJ cord-015306-us58wwmp 3883 18 in in IN cord-015306-us58wwmp 3883 19 granule granule NN cord-015306-us58wwmp 3883 20 formulation formulation NN cord-015306-us58wwmp 3883 21 ( ( -LRB- cord-015306-us58wwmp 3883 22 1 1 CD cord-015306-us58wwmp 3883 23 mg mg NN cord-015306-us58wwmp 3883 24 and and CC cord-015306-us58wwmp 3883 25 0.2 0.2 CD cord-015306-us58wwmp 3883 26 mg mg CD cord-015306-us58wwmp 3883 27 ) ) -RRB- cord-015306-us58wwmp 3883 28 that that WDT cord-015306-us58wwmp 3883 29 allows allow VBZ cord-015306-us58wwmp 3883 30 for for IN cord-015306-us58wwmp 3883 31 dosing dose VBG cord-015306-us58wwmp 3883 32 according accord VBG cord-015306-us58wwmp 3883 33 to to IN cord-015306-us58wwmp 3883 34 body body NN cord-015306-us58wwmp 3883 35 weight weight NN cord-015306-us58wwmp 3883 36 . . . cord-015306-us58wwmp 3884 1 Methods method NNS cord-015306-us58wwmp 3884 2 : : : cord-015306-us58wwmp 3885 1 All all DT cord-015306-us58wwmp 3885 2 paediatric paediatric JJ cord-015306-us58wwmp 3885 3 renal renal JJ cord-015306-us58wwmp 3885 4 transplant transplant NN cord-015306-us58wwmp 3885 5 recipients recipient NNS cord-015306-us58wwmp 3885 6 ( ( -LRB- cord-015306-us58wwmp 3885 7 RTR RTR NNP cord-015306-us58wwmp 3885 8 ) ) -RRB- cord-015306-us58wwmp 3885 9 under under IN cord-015306-us58wwmp 3885 10 the the DT cord-015306-us58wwmp 3885 11 care care NN cord-015306-us58wwmp 3885 12 of of IN cord-015306-us58wwmp 3885 13 a a DT cord-015306-us58wwmp 3885 14 single single JJ cord-015306-us58wwmp 3885 15 centre centre NN cord-015306-us58wwmp 3885 16 were be VBD cord-015306-us58wwmp 3885 17 considered consider VBN cord-015306-us58wwmp 3885 18 for for IN cord-015306-us58wwmp 3885 19 conversion conversion NN cord-015306-us58wwmp 3885 20 to to IN cord-015306-us58wwmp 3885 21 Modigraf Modigraf NNP cord-015306-us58wwmp 3886 1 ® ® VB cord-015306-us58wwmp 3886 2 from from IN cord-015306-us58wwmp 3886 3 their -PRON- PRP$ cord-015306-us58wwmp 3886 4 current current JJ cord-015306-us58wwmp 3886 5 Tacrolimus Tacrolimus NNP cord-015306-us58wwmp 3886 6 regimen regimen NN cord-015306-us58wwmp 3886 7 . . . cord-015306-us58wwmp 3887 1 Inclusion inclusion NN cord-015306-us58wwmp 3887 2 criteria criterion NNS cord-015306-us58wwmp 3887 3 included include VBD cord-015306-us58wwmp 3887 4 all all DT cord-015306-us58wwmp 3887 5 RTR RTR NNP cord-015306-us58wwmp 3887 6 under under IN cord-015306-us58wwmp 3887 7 18 18 CD cord-015306-us58wwmp 3887 8 years year NNS cord-015306-us58wwmp 3887 9 of of IN cord-015306-us58wwmp 3887 10 age age NN cord-015306-us58wwmp 3887 11 who who WP cord-015306-us58wwmp 3887 12 were be VBD cord-015306-us58wwmp 3887 13 on on IN cord-015306-us58wwmp 3887 14 Tacrolimus Tacrolimus NNP cord-015306-us58wwmp 3887 15 suspension suspension NN cord-015306-us58wwmp 3887 16 . . . cord-015306-us58wwmp 3888 1 Exclusion exclusion NN cord-015306-us58wwmp 3888 2 criteria criterion NNS cord-015306-us58wwmp 3888 3 included include VBD cord-015306-us58wwmp 3888 4 recipients recipient NNS cord-015306-us58wwmp 3888 5 of of IN cord-015306-us58wwmp 3888 6 multi multi JJ cord-015306-us58wwmp 3888 7 - - JJ cord-015306-us58wwmp 3888 8 organ organ JJ cord-015306-us58wwmp 3888 9 grafts graft NNS cord-015306-us58wwmp 3888 10 , , , cord-015306-us58wwmp 3888 11 patients patient NNS cord-015306-us58wwmp 3888 12 with with IN cord-015306-us58wwmp 3888 13 lactose lactose JJ cord-015306-us58wwmp 3888 14 intolerance intolerance NN cord-015306-us58wwmp 3888 15 and and CC cord-015306-us58wwmp 3888 16 patient patient JJ cord-015306-us58wwmp 3888 17 choice choice NN cord-015306-us58wwmp 3888 18 to to TO cord-015306-us58wwmp 3888 19 continue continue VB cord-015306-us58wwmp 3888 20 with with IN cord-015306-us58wwmp 3888 21 their -PRON- PRP$ cord-015306-us58wwmp 3888 22 current current JJ cord-015306-us58wwmp 3888 23 suspension suspension NN cord-015306-us58wwmp 3888 24 . . . cord-015306-us58wwmp 3889 1 Patients patient NNS cord-015306-us58wwmp 3889 2 were be VBD cord-015306-us58wwmp 3889 3 then then RB cord-015306-us58wwmp 3889 4 seen see VBN cord-015306-us58wwmp 3889 5 by by IN cord-015306-us58wwmp 3889 6 the the DT cord-015306-us58wwmp 3889 7 multi multi JJ cord-015306-us58wwmp 3889 8 - - JJ cord-015306-us58wwmp 3889 9 disciplinary disciplinary JJ cord-015306-us58wwmp 3889 10 team team NN cord-015306-us58wwmp 3889 11 . . . cord-015306-us58wwmp 3890 1 After after IN cord-015306-us58wwmp 3890 2 equivalent equivalent JJ cord-015306-us58wwmp 3890 3 dose dose NN cord-015306-us58wwmp 3890 4 conversion conversion NN cord-015306-us58wwmp 3890 5 , , , cord-015306-us58wwmp 3890 6 patients patient NNS cord-015306-us58wwmp 3890 7 were be VBD cord-015306-us58wwmp 3890 8 monitored monitor VBN cord-015306-us58wwmp 3890 9 with with IN cord-015306-us58wwmp 3890 10 blood blood NN cord-015306-us58wwmp 3890 11 tests test NNS cord-015306-us58wwmp 3890 12 one one CD cord-015306-us58wwmp 3890 13 week week NN cord-015306-us58wwmp 3890 14 after after IN cord-015306-us58wwmp 3890 15 conversion conversion NN cord-015306-us58wwmp 3890 16 with with IN cord-015306-us58wwmp 3890 17 subsequent subsequent JJ cord-015306-us58wwmp 3890 18 doses dose NNS cord-015306-us58wwmp 3890 19 adjusted adjust VBN cord-015306-us58wwmp 3890 20 accordingly accordingly RB cord-015306-us58wwmp 3890 21 . . . cord-015306-us58wwmp 3891 1 Patients patient NNS cord-015306-us58wwmp 3891 2 continue continue VBP cord-015306-us58wwmp 3891 3 to to TO cord-015306-us58wwmp 3891 4 be be VB cord-015306-us58wwmp 3891 5 monitored monitor VBN cord-015306-us58wwmp 3891 6 with with IN cord-015306-us58wwmp 3891 7 blood blood NN cord-015306-us58wwmp 3891 8 levels level NNS cord-015306-us58wwmp 3891 9 over over IN cord-015306-us58wwmp 3891 10 a a DT cord-015306-us58wwmp 3891 11 3 3 CD cord-015306-us58wwmp 3891 12 month month NN cord-015306-us58wwmp 3891 13 period period NN cord-015306-us58wwmp 3891 14 after after IN cord-015306-us58wwmp 3891 15 conversion conversion NN cord-015306-us58wwmp 3891 16 with with IN cord-015306-us58wwmp 3891 17 renal renal JJ cord-015306-us58wwmp 3891 18 allograft allograft NN cord-015306-us58wwmp 3891 19 function function NN cord-015306-us58wwmp 3891 20 , , , cord-015306-us58wwmp 3891 21 renal renal JJ cord-015306-us58wwmp 3891 22 allograft allograft NN cord-015306-us58wwmp 3891 23 loss loss NN cord-015306-us58wwmp 3891 24 and and CC cord-015306-us58wwmp 3891 25 side side NN cord-015306-us58wwmp 3891 26 - - HYPH cord-015306-us58wwmp 3891 27 effect effect NN cord-015306-us58wwmp 3891 28 profiles profile NNS cord-015306-us58wwmp 3891 29 recorded record VBN cord-015306-us58wwmp 3891 30 . . . cord-015306-us58wwmp 3892 1 Results result NNS cord-015306-us58wwmp 3892 2 : : : cord-015306-us58wwmp 3893 1 Forty forty CD cord-015306-us58wwmp 3893 2 - - HYPH cord-015306-us58wwmp 3893 3 three three CD cord-015306-us58wwmp 3893 4 ( ( -LRB- cord-015306-us58wwmp 3893 5 27 27 CD cord-015306-us58wwmp 3893 6 % % NN cord-015306-us58wwmp 3893 7 of of IN cord-015306-us58wwmp 3893 8 158 158 CD cord-015306-us58wwmp 3893 9 ) ) -RRB- cord-015306-us58wwmp 3894 1 RTR RTR NNP cord-015306-us58wwmp 3894 2 were be VBD cord-015306-us58wwmp 3894 3 considered consider VBN cord-015306-us58wwmp 3894 4 for for IN cord-015306-us58wwmp 3894 5 conversion conversion NN cord-015306-us58wwmp 3894 6 to to IN cord-015306-us58wwmp 3894 7 Modigraf Modigraf NNP cord-015306-us58wwmp 3894 8 ® ® NNP cord-015306-us58wwmp 3894 9 . . . cord-015306-us58wwmp 3895 1 The the DT cord-015306-us58wwmp 3895 2 families family NNS cord-015306-us58wwmp 3895 3 of of IN cord-015306-us58wwmp 3895 4 four four CD cord-015306-us58wwmp 3895 5 patients patient NNS cord-015306-us58wwmp 3895 6 requested request VBN cord-015306-us58wwmp 3895 7 to to TO cord-015306-us58wwmp 3895 8 stay stay VB cord-015306-us58wwmp 3895 9 on on IN cord-015306-us58wwmp 3895 10 their -PRON- PRP$ cord-015306-us58wwmp 3895 11 current current JJ cord-015306-us58wwmp 3895 12 Tacrolimus Tacrolimus NNP cord-015306-us58wwmp 3895 13 suspension suspension NN cord-015306-us58wwmp 3895 14 , , , cord-015306-us58wwmp 3895 15 three three CD cord-015306-us58wwmp 3895 16 patients patient NNS cord-015306-us58wwmp 3895 17 were be VBD cord-015306-us58wwmp 3895 18 deemed deem VBN cord-015306-us58wwmp 3895 19 unsuitable unsuitable JJ cord-015306-us58wwmp 3895 20 due due IN cord-015306-us58wwmp 3895 21 to to IN cord-015306-us58wwmp 3895 22 lactose lactose JJ cord-015306-us58wwmp 3895 23 intolerance intolerance NN cord-015306-us58wwmp 3895 24 and and CC cord-015306-us58wwmp 3895 25 three three CD cord-015306-us58wwmp 3895 26 patients patient NNS cord-015306-us58wwmp 3895 27 were be VBD cord-015306-us58wwmp 3895 28 excluded exclude VBN cord-015306-us58wwmp 3895 29 due due IN cord-015306-us58wwmp 3895 30 to to IN cord-015306-us58wwmp 3895 31 low low JJ cord-015306-us58wwmp 3895 32 doses dose NNS cord-015306-us58wwmp 3895 33 ( ( -LRB- cord-015306-us58wwmp 3895 34 incompatibility incompatibility NN cord-015306-us58wwmp 3895 35 with with IN cord-015306-us58wwmp 3895 36 the the DT cord-015306-us58wwmp 3895 37 granule granule NN cord-015306-us58wwmp 3895 38 dosing dose VBG cord-015306-us58wwmp 3895 39 ) ) -RRB- cord-015306-us58wwmp 3895 40 . . . cord-015306-us58wwmp 3896 1 Thirty thirty CD cord-015306-us58wwmp 3896 2 - - HYPH cord-015306-us58wwmp 3896 3 three three CD cord-015306-us58wwmp 3896 4 patients patient NNS cord-015306-us58wwmp 3896 5 were be VBD cord-015306-us58wwmp 3896 6 then then RB cord-015306-us58wwmp 3896 7 converted convert VBN cord-015306-us58wwmp 3896 8 to to IN cord-015306-us58wwmp 3896 9 Modigraf Modigraf NNP cord-015306-us58wwmp 3896 10 ® ® . cord-015306-us58wwmp 3896 11 and and CC cord-015306-us58wwmp 3896 12 closely closely RB cord-015306-us58wwmp 3896 13 monitored monitor VBN cord-015306-us58wwmp 3896 14 . . . cord-015306-us58wwmp 3897 1 After after IN cord-015306-us58wwmp 3897 2 blood blood NN cord-015306-us58wwmp 3897 3 level level NN cord-015306-us58wwmp 3897 4 monitoring monitor VBG cord-015306-us58wwmp 3897 5 one one CD cord-015306-us58wwmp 3897 6 week week NN cord-015306-us58wwmp 3897 7 after after IN cord-015306-us58wwmp 3897 8 conversion conversion NN cord-015306-us58wwmp 3897 9 , , , cord-015306-us58wwmp 3897 10 12 12 CD cord-015306-us58wwmp 3897 11 % % NN cord-015306-us58wwmp 3897 12 ( ( -LRB- cord-015306-us58wwmp 3897 13 4 4 CD cord-015306-us58wwmp 3897 14 ) ) -RRB- cord-015306-us58wwmp 3897 15 patients patient NNS cord-015306-us58wwmp 3897 16 had have VBD cord-015306-us58wwmp 3897 17 their -PRON- PRP$ cord-015306-us58wwmp 3897 18 doses dose NNS cord-015306-us58wwmp 3897 19 increased increase VBN cord-015306-us58wwmp 3897 20 due due IN cord-015306-us58wwmp 3897 21 to to IN cord-015306-us58wwmp 3897 22 lower low JJR cord-015306-us58wwmp 3897 23 than than IN cord-015306-us58wwmp 3897 24 anticipated anticipate VBN cord-015306-us58wwmp 3897 25 12-hour 12-hour CD cord-015306-us58wwmp 3897 26 trough trough NN cord-015306-us58wwmp 3897 27 tacrolimus tacrolimus NN cord-015306-us58wwmp 3897 28 levels level NNS cord-015306-us58wwmp 3897 29 . . . cord-015306-us58wwmp 3898 1 There there EX cord-015306-us58wwmp 3898 2 was be VBD cord-015306-us58wwmp 3898 3 stable stable JJ cord-015306-us58wwmp 3898 4 renal renal JJ cord-015306-us58wwmp 3898 5 allograft allograft NN cord-015306-us58wwmp 3898 6 function function NN cord-015306-us58wwmp 3898 7 without without IN cord-015306-us58wwmp 3898 8 renal renal JJ cord-015306-us58wwmp 3898 9 allograft allograft NN cord-015306-us58wwmp 3898 10 loss loss NN cord-015306-us58wwmp 3898 11 after after IN cord-015306-us58wwmp 3898 12 conversion conversion NN cord-015306-us58wwmp 3898 13 . . . cord-015306-us58wwmp 3899 1 Conclusion conclusion NN cord-015306-us58wwmp 3899 2 : : : cord-015306-us58wwmp 3899 3 Conversion conversion NN cord-015306-us58wwmp 3899 4 to to IN cord-015306-us58wwmp 3899 5 Modigraf Modigraf NNP cord-015306-us58wwmp 3900 1 ® ® LS cord-015306-us58wwmp 3900 2 immunosuppression immunosuppression NN cord-015306-us58wwmp 3900 3 can can MD cord-015306-us58wwmp 3900 4 be be VB cord-015306-us58wwmp 3900 5 safely safely RB cord-015306-us58wwmp 3900 6 undertaken undertake VBN cord-015306-us58wwmp 3900 7 in in IN cord-015306-us58wwmp 3900 8 paediatric paediatric JJ cord-015306-us58wwmp 3900 9 RTR RTR NNP cord-015306-us58wwmp 3900 10 , , , cord-015306-us58wwmp 3900 11 although although IN cord-015306-us58wwmp 3900 12 regular regular JJ cord-015306-us58wwmp 3900 13 monitoring monitoring NN cord-015306-us58wwmp 3900 14 in in IN cord-015306-us58wwmp 3900 15 the the DT cord-015306-us58wwmp 3900 16 immediate immediate JJ cord-015306-us58wwmp 3900 17 period period NN cord-015306-us58wwmp 3900 18 of of IN cord-015306-us58wwmp 3900 19 conversion conversion NN cord-015306-us58wwmp 3900 20 is be VBZ cord-015306-us58wwmp 3900 21 required require VBN cord-015306-us58wwmp 3900 22 to to TO cord-015306-us58wwmp 3900 23 provide provide VB cord-015306-us58wwmp 3900 24 accurate accurate JJ cord-015306-us58wwmp 3900 25 immunosuppression immunosuppression NN cord-015306-us58wwmp 3900 26 dosing dose VBG cord-015306-us58wwmp 3900 27 . . . cord-015306-us58wwmp 3901 1 ESCORT escort JJ cord-015306-us58wwmp 3901 2 trial trial NN cord-015306-us58wwmp 3901 3 -Effects -effect NNS cord-015306-us58wwmp 3901 4 of of IN cord-015306-us58wwmp 3901 5 strict strict JJ cord-015306-us58wwmp 3901 6 control control NN cord-015306-us58wwmp 3901 7 of of IN cord-015306-us58wwmp 3901 8 blood blood NN cord-015306-us58wwmp 3901 9 pressure pressure NN cord-015306-us58wwmp 3901 10 in in IN cord-015306-us58wwmp 3901 11 pediatric pediatric JJ cord-015306-us58wwmp 3901 12 renal renal JJ cord-015306-us58wwmp 3901 13 transplant transplant NN cord-015306-us58wwmp 3901 14 recipients recipient NNS cord-015306-us58wwmp 3901 15 -Baseline -Baseline : cord-015306-us58wwmp 3901 16 characteristics characteristic NNS cord-015306-us58wwmp 3901 17 of of IN cord-015306-us58wwmp 3901 18 patients patient NNS cord-015306-us58wwmp 3901 19 from from IN cord-015306-us58wwmp 3901 20 a a DT cord-015306-us58wwmp 3901 21 randomized randomized JJ cord-015306-us58wwmp 3901 22 controlled control VBN cord-015306-us58wwmp 3901 23 trial trial NN cord-015306-us58wwmp 3901 24 Tomas Tomas NNP cord-015306-us58wwmp 3901 25 Seeman Seeman NNP cord-015306-us58wwmp 3901 26 , , , cord-015306-us58wwmp 3901 27 Jiri Jiri NNP cord-015306-us58wwmp 3901 28 Dusek Dusek NNP cord-015306-us58wwmp 3901 29 , , , cord-015306-us58wwmp 3901 30 Nadezda Nadezda NNP cord-015306-us58wwmp 3901 31 Simankova Simankova NNP cord-015306-us58wwmp 3901 32 , , , cord-015306-us58wwmp 3901 33 Karel Karel NNP cord-015306-us58wwmp 3901 34 Vondrak Vondrak NNP cord-015306-us58wwmp 3901 35 , , , cord-015306-us58wwmp 3901 36 Jakub Jakub NNP cord-015306-us58wwmp 3901 37 Zieg Zieg NNP cord-015306-us58wwmp 3901 38 Dpt Dpt NNP cord-015306-us58wwmp 3901 39 . . . cord-015306-us58wwmp 3901 40 of of IN cord-015306-us58wwmp 3901 41 Pediatrics Pediatrics NNP cord-015306-us58wwmp 3901 42 , , , cord-015306-us58wwmp 3901 43 University University NNP cord-015306-us58wwmp 3901 44 Hospital Hospital NNP cord-015306-us58wwmp 3901 45 Motol Motol NNP cord-015306-us58wwmp 3901 46 , , , cord-015306-us58wwmp 3901 47 Prague Prague NNP cord-015306-us58wwmp 3901 48 , , , cord-015306-us58wwmp 3901 49 Czech Czech NNP cord-015306-us58wwmp 3901 50 Republic Republic NNP cord-015306-us58wwmp 3901 51 Objective Objective NNP cord-015306-us58wwmp 3901 52 : : : cord-015306-us58wwmp 3901 53 Arterial arterial JJ cord-015306-us58wwmp 3901 54 hypertension hypertension NN cord-015306-us58wwmp 3901 55 is be VBZ cord-015306-us58wwmp 3901 56 a a DT cord-015306-us58wwmp 3901 57 known know VBN cord-015306-us58wwmp 3901 58 risk risk NN cord-015306-us58wwmp 3901 59 factor factor NN cord-015306-us58wwmp 3901 60 for for IN cord-015306-us58wwmp 3901 61 impaired impaired JJ cord-015306-us58wwmp 3901 62 graft graft NN cord-015306-us58wwmp 3901 63 survival survival NN cord-015306-us58wwmp 3901 64 in in IN cord-015306-us58wwmp 3901 65 patients patient NNS cord-015306-us58wwmp 3901 66 after after IN cord-015306-us58wwmp 3901 67 renal renal JJ cord-015306-us58wwmp 3901 68 transplantation transplantation NN cord-015306-us58wwmp 3901 69 ( ( -LRB- cord-015306-us58wwmp 3901 70 RTx RTx NNP cord-015306-us58wwmp 3901 71 ) ) -RRB- cord-015306-us58wwmp 3901 72 . . . cord-015306-us58wwmp 3902 1 Strict strict JJ cord-015306-us58wwmp 3902 2 control control NN cord-015306-us58wwmp 3902 3 of of IN cord-015306-us58wwmp 3902 4 blood blood NN cord-015306-us58wwmp 3902 5 pressure pressure NN cord-015306-us58wwmp 3902 6 ( ( -LRB- cord-015306-us58wwmp 3902 7 BP BP NNP cord-015306-us58wwmp 3902 8 < < XX cord-015306-us58wwmp 3902 9 50 50 CD cord-015306-us58wwmp 3902 10 th th XX cord-015306-us58wwmp 3902 11 percentile percentile NN cord-015306-us58wwmp 3902 12 ) ) -RRB- cord-015306-us58wwmp 3902 13 delays delay NNS cord-015306-us58wwmp 3902 14 progression progression NN cord-015306-us58wwmp 3902 15 of of IN cord-015306-us58wwmp 3902 16 chronic chronic JJ cord-015306-us58wwmp 3902 17 kidney kidney NN cord-015306-us58wwmp 3902 18 diseases disease NNS cord-015306-us58wwmp 3902 19 in in IN cord-015306-us58wwmp 3902 20 children child NNS cord-015306-us58wwmp 3902 21 ( ( -LRB- cord-015306-us58wwmp 3902 22 ESCAPE escape VB cord-015306-us58wwmp 3902 23 trial trial NN cord-015306-us58wwmp 3902 24 ) ) -RRB- cord-015306-us58wwmp 3902 25 . . . cord-015306-us58wwmp 3903 1 It -PRON- PRP cord-015306-us58wwmp 3903 2 is be VBZ cord-015306-us58wwmp 3903 3 not not RB cord-015306-us58wwmp 3903 4 known know VBN cord-015306-us58wwmp 3903 5 whether whether IN cord-015306-us58wwmp 3903 6 strict strict JJ cord-015306-us58wwmp 3903 7 BP BP NNP cord-015306-us58wwmp 3903 8 control control NN cord-015306-us58wwmp 3903 9 has have VBZ cord-015306-us58wwmp 3903 10 renoprotective renoprotective JJ cord-015306-us58wwmp 3903 11 effect effect NN cord-015306-us58wwmp 3903 12 also also RB cord-015306-us58wwmp 3903 13 in in IN cord-015306-us58wwmp 3903 14 children child NNS cord-015306-us58wwmp 3903 15 after after IN cord-015306-us58wwmp 3903 16 RTx RTx NNS cord-015306-us58wwmp 3903 17 . . . cord-015306-us58wwmp 3904 1 The the DT cord-015306-us58wwmp 3904 2 aim aim NN cord-015306-us58wwmp 3904 3 of of IN cord-015306-us58wwmp 3904 4 this this DT cord-015306-us58wwmp 3904 5 randomized randomize VBN cord-015306-us58wwmp 3904 6 controlled control VBN cord-015306-us58wwmp 3904 7 trial trial NN cord-015306-us58wwmp 3904 8 was be VBD cord-015306-us58wwmp 3904 9 to to TO cord-015306-us58wwmp 3904 10 investigate investigate VB cord-015306-us58wwmp 3904 11 whether whether IN cord-015306-us58wwmp 3904 12 strict strict JJ cord-015306-us58wwmp 3904 13 BP BP NNP cord-015306-us58wwmp 3904 14 control control NN cord-015306-us58wwmp 3904 15 can can MD cord-015306-us58wwmp 3904 16 protect protect VB cord-015306-us58wwmp 3904 17 kidney kidney NN cord-015306-us58wwmp 3904 18 graft graft NN cord-015306-us58wwmp 3904 19 in in IN cord-015306-us58wwmp 3904 20 children child NNS cord-015306-us58wwmp 3904 21 after after IN cord-015306-us58wwmp 3904 22 RTx RTx NNS cord-015306-us58wwmp 3904 23 . . . cord-015306-us58wwmp 3905 1 Methods method NNS cord-015306-us58wwmp 3905 2 : : : cord-015306-us58wwmp 3905 3 All all DT cord-015306-us58wwmp 3905 4 children child NNS cord-015306-us58wwmp 3905 5 from from IN cord-015306-us58wwmp 3905 6 our -PRON- PRP$ cord-015306-us58wwmp 3905 7 pediatric pediatric JJ cord-015306-us58wwmp 3905 8 renal renal JJ cord-015306-us58wwmp 3905 9 transplantation transplantation NN cord-015306-us58wwmp 3905 10 center center NN cord-015306-us58wwmp 3905 11 were be VBD cord-015306-us58wwmp 3905 12 screened screen VBN cord-015306-us58wwmp 3905 13 for for IN cord-015306-us58wwmp 3905 14 eligibility eligibility NN cord-015306-us58wwmp 3905 15 for for IN cord-015306-us58wwmp 3905 16 the the DT cord-015306-us58wwmp 3905 17 study study NN cord-015306-us58wwmp 3905 18 ( ( -LRB- cord-015306-us58wwmp 3905 19 children child NNS cord-015306-us58wwmp 3905 20 3 3 CD cord-015306-us58wwmp 3905 21 - - SYM cord-015306-us58wwmp 3905 22 16 16 CD cord-015306-us58wwmp 3905 23 years year NNS cord-015306-us58wwmp 3905 24 at at IN cord-015306-us58wwmp 3905 25 least least JJS cord-015306-us58wwmp 3905 26 1 1 CD cord-015306-us58wwmp 3905 27 year year NN cord-015306-us58wwmp 3905 28 after after IN cord-015306-us58wwmp 3905 29 RTx RTx NNS cord-015306-us58wwmp 3905 30 , , , cord-015306-us58wwmp 3905 31 no no DT cord-015306-us58wwmp 3905 32 acute acute JJ cord-015306-us58wwmp 3905 33 rejection rejection NN cord-015306-us58wwmp 3905 34 in in IN cord-015306-us58wwmp 3905 35 the the DT cord-015306-us58wwmp 3905 36 last last JJ cord-015306-us58wwmp 3905 37 3 3 CD cord-015306-us58wwmp 3905 38 months month NNS cord-015306-us58wwmp 3905 39 , , , cord-015306-us58wwmp 3906 1 eGFR>15 eGFR>15 NNP cord-015306-us58wwmp 3906 2 ml ml NNP cord-015306-us58wwmp 3906 3 / / SYM cord-015306-us58wwmp 3906 4 min/1.73m2 min/1.73m2 NNP cord-015306-us58wwmp 3906 5 , , , cord-015306-us58wwmp 3906 6 24hr 24hr JJ cord-015306-us58wwmp 3906 7 mean mean NN cord-015306-us58wwmp 3906 8 BP BP NNP cord-015306-us58wwmp 3907 1 > > XX cord-015306-us58wwmp 3908 1 50 50 CD cord-015306-us58wwmp 3908 2 th th XX cord-015306-us58wwmp 3908 3 percentile percentile JJ cord-015306-us58wwmp 3908 4 using use VBG cord-015306-us58wwmp 3908 5 ambulatory ambulatory JJ cord-015306-us58wwmp 3908 6 blood blood NN cord-015306-us58wwmp 3908 7 pressure pressure NN cord-015306-us58wwmp 3908 8 monitoring monitor VBG cord-015306-us58wwmp 3908 9 ABPM ABPM NNP cord-015306-us58wwmp 3908 10 ) ) -RRB- cord-015306-us58wwmp 3908 11 . . . cord-015306-us58wwmp 3909 1 Altogether altogether RB cord-015306-us58wwmp 3909 2 23 23 CD cord-015306-us58wwmp 3909 3 children child NNS cord-015306-us58wwmp 3909 4 fulfilled fulfil VBD cord-015306-us58wwmp 3909 5 the the DT cord-015306-us58wwmp 3909 6 inclusion inclusion NN cord-015306-us58wwmp 3909 7 criteria criterion NNS cord-015306-us58wwmp 3909 8 . . . cord-015306-us58wwmp 3910 1 They -PRON- PRP cord-015306-us58wwmp 3910 2 were be VBD cord-015306-us58wwmp 3910 3 randomized randomize VBN cord-015306-us58wwmp 3910 4 to to IN cord-015306-us58wwmp 3910 5 intensified intensify VBN cord-015306-us58wwmp 3910 6 BP BP NNP cord-015306-us58wwmp 3910 7 control control NN cord-015306-us58wwmp 3910 8 group group NN cord-015306-us58wwmp 3910 9 ( ( -LRB- cord-015306-us58wwmp 3910 10 INTENS INTENS NNP cord-015306-us58wwmp 3910 11 , , , cord-015306-us58wwmp 3910 12 target target VB cord-015306-us58wwmp 3910 13 24hr 24hr JJ cord-015306-us58wwmp 3910 14 MAP map NN cord-015306-us58wwmp 3910 15 < < XX cord-015306-us58wwmp 3910 16 50 50 CD cord-015306-us58wwmp 3910 17 th th XX cord-015306-us58wwmp 3910 18 percentile percentile NN cord-015306-us58wwmp 3910 19 , , , cord-015306-us58wwmp 3910 20 n=12 n=12 NNP cord-015306-us58wwmp 3910 21 ) ) -RRB- cord-015306-us58wwmp 3910 22 or or CC cord-015306-us58wwmp 3910 23 standard standard JJ cord-015306-us58wwmp 3910 24 BP BP NNP cord-015306-us58wwmp 3910 25 control control NN cord-015306-us58wwmp 3910 26 group group NN cord-015306-us58wwmp 3910 27 ( ( -LRB- cord-015306-us58wwmp 3910 28 STAND stand VB cord-015306-us58wwmp 3910 29 , , , cord-015306-us58wwmp 3910 30 target target VB cord-015306-us58wwmp 3910 31 24hr 24hr JJ cord-015306-us58wwmp 3910 32 MAP MAP NNP cord-015306-us58wwmp 3910 33 50 50 CD cord-015306-us58wwmp 3910 34 - - SYM cord-015306-us58wwmp 3910 35 95 95 CD cord-015306-us58wwmp 3910 36 th th XX cord-015306-us58wwmp 3910 37 percentile percentile NN cord-015306-us58wwmp 3910 38 , , , cord-015306-us58wwmp 3910 39 n=11 n=11 FW cord-015306-us58wwmp 3910 40 ) ) -RRB- cord-015306-us58wwmp 3910 41 . . . cord-015306-us58wwmp 3911 1 All all DT cord-015306-us58wwmp 3911 2 antihypertensive antihypertensive JJ cord-015306-us58wwmp 3911 3 drugs drug NNS cord-015306-us58wwmp 3911 4 are be VBP cord-015306-us58wwmp 3911 5 allowed allow VBN cord-015306-us58wwmp 3911 6 to to TO cord-015306-us58wwmp 3911 7 reach reach VB cord-015306-us58wwmp 3911 8 the the DT cord-015306-us58wwmp 3911 9 target target NN cord-015306-us58wwmp 3911 10 BP BP NNP cord-015306-us58wwmp 3911 11 . . . cord-015306-us58wwmp 3912 1 The the DT cord-015306-us58wwmp 3912 2 study study NN cord-015306-us58wwmp 3912 3 period period NN cord-015306-us58wwmp 3912 4 is be VBZ cord-015306-us58wwmp 3912 5 3 3 CD cord-015306-us58wwmp 3912 6 years year NNS cord-015306-us58wwmp 3912 7 . . . cord-015306-us58wwmp 3913 1 The the DT cord-015306-us58wwmp 3913 2 primary primary JJ cord-015306-us58wwmp 3913 3 endpoint endpoint NN cord-015306-us58wwmp 3913 4 is be VBZ cord-015306-us58wwmp 3913 5 the the DT cord-015306-us58wwmp 3913 6 yearly yearly JJ cord-015306-us58wwmp 3913 7 change change NN cord-015306-us58wwmp 3913 8 in in IN cord-015306-us58wwmp 3914 1 eGFR egfr XX cord-015306-us58wwmp 3914 2 ( ( -LRB- cord-015306-us58wwmp 3914 3 Schwartz Schwartz NNP cord-015306-us58wwmp 3914 4 formula formula NN cord-015306-us58wwmp 3914 5 , , , cord-015306-us58wwmp 3914 6 ml ml NN cord-015306-us58wwmp 3914 7 / / SYM cord-015306-us58wwmp 3914 8 min/1.73m2 min/1.73m2 NNP cord-015306-us58wwmp 3914 9 / / SYM cord-015306-us58wwmp 3914 10 year year NN cord-015306-us58wwmp 3914 11 ) ) -RRB- cord-015306-us58wwmp 3914 12 , , , cord-015306-us58wwmp 3914 13 the the DT cord-015306-us58wwmp 3914 14 secondary secondary JJ cord-015306-us58wwmp 3914 15 endpoints endpoint NNS cord-015306-us58wwmp 3914 16 are be VBP cord-015306-us58wwmp 3914 17 graft graft NN cord-015306-us58wwmp 3914 18 failure failure NN cord-015306-us58wwmp 3914 19 , , , cord-015306-us58wwmp 3914 20 change change NN cord-015306-us58wwmp 3914 21 in in IN cord-015306-us58wwmp 3914 22 proteinuria proteinuria NN cord-015306-us58wwmp 3914 23 , , , cord-015306-us58wwmp 3914 24 left leave VBD cord-015306-us58wwmp 3914 25 ventricular ventricular JJ cord-015306-us58wwmp 3914 26 mass mass NN cord-015306-us58wwmp 3914 27 and and CC cord-015306-us58wwmp 3914 28 safety safety NN cord-015306-us58wwmp 3914 29 of of IN cord-015306-us58wwmp 3914 30 strict strict JJ cord-015306-us58wwmp 3914 31 control control NN cord-015306-us58wwmp 3914 32 of of IN cord-015306-us58wwmp 3914 33 BP BP NNP cord-015306-us58wwmp 3914 34 . . . cord-015306-us58wwmp 3915 1 Results result NNS cord-015306-us58wwmp 3915 2 : : : cord-015306-us58wwmp 3916 1 The the DT cord-015306-us58wwmp 3916 2 baseline baseline JJ cord-015306-us58wwmp 3916 3 characteristics characteristic NNS cord-015306-us58wwmp 3916 4 of of IN cord-015306-us58wwmp 3916 5 the the DT cord-015306-us58wwmp 3916 6 patients patient NNS cord-015306-us58wwmp 3916 7 are be VBP cord-015306-us58wwmp 3916 8 given give VBN cord-015306-us58wwmp 3916 9 in in IN cord-015306-us58wwmp 3916 10 the the DT cord-015306-us58wwmp 3916 11 allelic allelic JJ cord-015306-us58wwmp 3916 12 variants variant NNS cord-015306-us58wwmp 3916 13 . . . cord-015306-us58wwmp 3917 1 TAC TAC NNP cord-015306-us58wwmp 3917 2 dose dose NN cord-015306-us58wwmp 3917 3 ( ( -LRB- cord-015306-us58wwmp 3917 4 mg mg NNP cord-015306-us58wwmp 3917 5 / / SYM cord-015306-us58wwmp 3917 6 kg kg NNP cord-015306-us58wwmp 3917 7 / / SYM cord-015306-us58wwmp 3917 8 day day NN cord-015306-us58wwmp 3917 9 ) ) -RRB- cord-015306-us58wwmp 3917 10 and and CC cord-015306-us58wwmp 3917 11 TAC TAC NNP cord-015306-us58wwmp 3917 12 exposure exposure NN cord-015306-us58wwmp 3917 13 normalized normalize VBN cord-015306-us58wwmp 3917 14 for for IN cord-015306-us58wwmp 3917 15 dose dose NN cord-015306-us58wwmp 3917 16 ( ( -LRB- cord-015306-us58wwmp 3917 17 TAC TAC NNP cord-015306-us58wwmp 3917 18 Co Co NNP cord-015306-us58wwmp 3917 19 / / SYM cord-015306-us58wwmp 3917 20 D d NN cord-015306-us58wwmp 3917 21 ) ) -RRB- cord-015306-us58wwmp 3918 1 ( ( -LRB- cord-015306-us58wwmp 3918 2 ng ng NNP cord-015306-us58wwmp 3918 3 / / SYM cord-015306-us58wwmp 3918 4 ml ml NNP cord-015306-us58wwmp 3918 5 / / SYM cord-015306-us58wwmp 3918 6 mg mg NNP cord-015306-us58wwmp 3918 7 / / SYM cord-015306-us58wwmp 3918 8 kg kg NNP cord-015306-us58wwmp 3918 9 / / SYM cord-015306-us58wwmp 3918 10 day day NN cord-015306-us58wwmp 3918 11 ) ) -RRB- cord-015306-us58wwmp 3918 12 were be VBD cord-015306-us58wwmp 3918 13 analyzed analyze VBN cord-015306-us58wwmp 3918 14 with with IN cord-015306-us58wwmp 3918 15 respect respect NN cord-015306-us58wwmp 3918 16 to to IN cord-015306-us58wwmp 3918 17 CYP3A5 CYP3A5 NNP cord-015306-us58wwmp 3918 18 genotype genotype NN cord-015306-us58wwmp 3918 19 and and CC cord-015306-us58wwmp 3918 20 for for IN cord-015306-us58wwmp 3918 21 interaction interaction NN cord-015306-us58wwmp 3918 22 with with IN cord-015306-us58wwmp 3918 23 azoles azole NNS cord-015306-us58wwmp 3918 24 and and CC cord-015306-us58wwmp 3918 25 corticosteroids corticosteroid NNS cord-015306-us58wwmp 3918 26 , , , cord-015306-us58wwmp 3918 27 for for IN cord-015306-us58wwmp 3918 28 a a DT cord-015306-us58wwmp 3918 29 period period NN cord-015306-us58wwmp 3918 30 of of IN cord-015306-us58wwmp 3918 31 one one CD cord-015306-us58wwmp 3918 32 year year NN cord-015306-us58wwmp 3918 33 post post NN cord-015306-us58wwmp 3918 34 - - NN cord-015306-us58wwmp 3918 35 transplant transplant NN cord-015306-us58wwmp 3918 36 . . . cord-015306-us58wwmp 3919 1 Over over IN cord-015306-us58wwmp 3919 2 time time NN cord-015306-us58wwmp 3919 3 , , , cord-015306-us58wwmp 3919 4 TAC TAC NNP cord-015306-us58wwmp 3919 5 Co Co NNP cord-015306-us58wwmp 3919 6 / / SYM cord-015306-us58wwmp 3919 7 D D NNP cord-015306-us58wwmp 3919 8 was be VBD cord-015306-us58wwmp 3919 9 significantly significantly RB cord-015306-us58wwmp 3919 10 lower low JJR cord-015306-us58wwmp 3919 11 in in IN cord-015306-us58wwmp 3919 12 recipients recipient NNS cord-015306-us58wwmp 3919 13 with with IN cord-015306-us58wwmp 3919 14 a a DT cord-015306-us58wwmp 3919 15 CYP3A5 CYP3A5 NNP cord-015306-us58wwmp 3919 16 * * NFP cord-015306-us58wwmp 3919 17 1/*3 1/*3 CD cord-015306-us58wwmp 3919 18 genotype genotype NN cord-015306-us58wwmp 3919 19 compared compare VBN cord-015306-us58wwmp 3919 20 to to IN cord-015306-us58wwmp 3919 21 those those DT cord-015306-us58wwmp 3919 22 being be VBG cord-015306-us58wwmp 3919 23 homozygous homozygous JJ cord-015306-us58wwmp 3919 24 for for IN cord-015306-us58wwmp 3919 25 the the DT cord-015306-us58wwmp 3919 26 CYP3A5 CYP3A5 NNP cord-015306-us58wwmp 3919 27 * * SYM cord-015306-us58wwmp 3919 28 3 3 CD cord-015306-us58wwmp 3919 29 allele allele NN cord-015306-us58wwmp 3919 30 ( ( -LRB- cord-015306-us58wwmp 3919 31 55.33 55.33 CD cord-015306-us58wwmp 3919 32 + + CC cord-015306-us58wwmp 3919 33 /-21.30 /-21.30 . cord-015306-us58wwmp 3920 1 versus versus IN cord-015306-us58wwmp 3920 2 83.07 83.07 CD cord-015306-us58wwmp 3920 3 + + CC cord-015306-us58wwmp 3920 4 /-9.9 /-9.9 . cord-015306-us58wwmp 3921 1 ng ng NNP cord-015306-us58wwmp 3922 1 /ml /ml NFP cord-015306-us58wwmp 3922 2 / / SYM cord-015306-us58wwmp 3922 3 mg mg NNP cord-015306-us58wwmp 3922 4 / / SYM cord-015306-us58wwmp 3922 5 kg kg NNP cord-015306-us58wwmp 3922 6 / / SYM cord-015306-us58wwmp 3922 7 day day NN cord-015306-us58wwmp 3922 8 , , , cord-015306-us58wwmp 3922 9 P= P= NNP cord-015306-us58wwmp 3922 10 0.0068 0.0068 CD cord-015306-us58wwmp 3922 11 ) ) -RRB- cord-015306-us58wwmp 3922 12 . . . cord-015306-us58wwmp 3923 1 The the DT cord-015306-us58wwmp 3923 2 dose dose JJ cord-015306-us58wwmp 3923 3 requirement requirement NN cord-015306-us58wwmp 3923 4 was be VBD cord-015306-us58wwmp 3923 5 significantly significantly RB cord-015306-us58wwmp 3923 6 higher high JJR cord-015306-us58wwmp 3923 7 in in IN cord-015306-us58wwmp 3923 8 children child NNS cord-015306-us58wwmp 3923 9 with with IN cord-015306-us58wwmp 3923 10 a a DT cord-015306-us58wwmp 3923 11 CYP3A5 CYP3A5 NNP cord-015306-us58wwmp 3923 12 * * NFP cord-015306-us58wwmp 3923 13 1/*3 1/*3 CD cord-015306-us58wwmp 3923 14 genotype genotype NN cord-015306-us58wwmp 3923 15 compared compare VBN cord-015306-us58wwmp 3923 16 to to IN cord-015306-us58wwmp 3923 17 those those DT cord-015306-us58wwmp 3923 18 being be VBG cord-015306-us58wwmp 3923 19 CYP3 CYP3 NNP cord-015306-us58wwmp 3923 20 * * NFP cord-015306-us58wwmp 3924 1 3/*3 3/*3 LS cord-015306-us58wwmp 3924 2 ( ( -LRB- cord-015306-us58wwmp 3924 3 0.21 0.21 CD cord-015306-us58wwmp 3924 4 + + CC cord-015306-us58wwmp 3924 5 /-0.02 /-0.02 . cord-015306-us58wwmp 3925 1 versus versus IN cord-015306-us58wwmp 3925 2 0.17 0.17 CD cord-015306-us58wwmp 3925 3 + + CC cord-015306-us58wwmp 3925 4 /-0.01 /-0.01 . cord-015306-us58wwmp 3926 1 mg mg NNP cord-015306-us58wwmp 3926 2 / / SYM cord-015306-us58wwmp 3926 3 kg kg NNP cord-015306-us58wwmp 3926 4 day day NN cord-015306-us58wwmp 3926 5 , , , cord-015306-us58wwmp 3926 6 p=0.0079 p=0.0079 NNP cord-015306-us58wwmp 3926 7 ) ) -RRB- cord-015306-us58wwmp 3926 8 . . . cord-015306-us58wwmp 3927 1 The the DT cord-015306-us58wwmp 3927 2 TAC TAC NNP cord-015306-us58wwmp 3927 3 Co Co NNP cord-015306-us58wwmp 3927 4 / / SYM cord-015306-us58wwmp 3927 5 D D NNP cord-015306-us58wwmp 3927 6 was be VBD cord-015306-us58wwmp 3927 7 significantly significantly RB cord-015306-us58wwmp 3927 8 higher high JJR cord-015306-us58wwmp 3927 9 for for IN cord-015306-us58wwmp 3927 10 patients patient NNS cord-015306-us58wwmp 3927 11 receiving receive VBG cord-015306-us58wwmp 3927 12 azoles azole NNS cord-015306-us58wwmp 3927 13 ( ( -LRB- cord-015306-us58wwmp 3927 14 n=17 n=17 NNP cord-015306-us58wwmp 3927 15 ) ) -RRB- cord-015306-us58wwmp 3927 16 than than IN cord-015306-us58wwmp 3927 17 those those DT cord-015306-us58wwmp 3927 18 not not RB cord-015306-us58wwmp 3927 19 receiving receive VBG cord-015306-us58wwmp 3927 20 azoles azole NNS cord-015306-us58wwmp 3927 21 ( ( -LRB- cord-015306-us58wwmp 3927 22 n=40 n=40 NNP cord-015306-us58wwmp 3927 23 ) ) -RRB- cord-015306-us58wwmp 3927 24 ( ( -LRB- cord-015306-us58wwmp 3927 25 117.21 117.21 CD cord-015306-us58wwmp 3927 26 + + SYM cord-015306-us58wwmp 3927 27 /-1.06 /-1.06 NNS cord-015306-us58wwmp 3927 28 and and CC cord-015306-us58wwmp 3927 29 62.01 62.01 CD cord-015306-us58wwmp 3927 30 + + CC cord-015306-us58wwmp 3927 31 /-0.52 /-0.52 . cord-015306-us58wwmp 3928 1 ng ng NNP cord-015306-us58wwmp 3928 2 / / SYM cord-015306-us58wwmp 3928 3 ml ml NNP cord-015306-us58wwmp 3928 4 / / SYM cord-015306-us58wwmp 3928 5 mg mg NNP cord-015306-us58wwmp 3928 6 / / SYM cord-015306-us58wwmp 3928 7 kg kg NNP cord-015306-us58wwmp 3928 8 / / SYM cord-015306-us58wwmp 3928 9 day day NN cord-015306-us58wwmp 3928 10 , , , cord-015306-us58wwmp 3928 11 P= P= NNP cord-015306-us58wwmp 3928 12 0.002 0.002 CD cord-015306-us58wwmp 3928 13 ) ) -RRB- cord-015306-us58wwmp 3929 1 and and CC cord-015306-us58wwmp 3929 2 consequently consequently RB cord-015306-us58wwmp 3929 3 the the DT cord-015306-us58wwmp 3929 4 required require VBN cord-015306-us58wwmp 3929 5 TAC TAC NNP cord-015306-us58wwmp 3929 6 dose dose NN cord-015306-us58wwmp 3929 7 was be VBD cord-015306-us58wwmp 3929 8 lower low JJR cord-015306-us58wwmp 3929 9 in in IN cord-015306-us58wwmp 3929 10 patients patient NNS cord-015306-us58wwmp 3929 11 receiving receive VBG cord-015306-us58wwmp 3929 12 azoles azole NNS cord-015306-us58wwmp 3929 13 overtime overtime NN cord-015306-us58wwmp 3929 14 ( ( -LRB- cord-015306-us58wwmp 3929 15 0.08 0.08 CD cord-015306-us58wwmp 3929 16 + + CC cord-015306-us58wwmp 3929 17 /-0.00 /-0.00 NN cord-015306-us58wwmp 3929 18 versus versus IN cord-015306-us58wwmp 3929 19 0.22 0.22 CD cord-015306-us58wwmp 3929 20 + + CC cord-015306-us58wwmp 3929 21 /-0.01 /-0.01 . cord-015306-us58wwmp 3930 1 mg mg NNP cord-015306-us58wwmp 3930 2 / / SYM cord-015306-us58wwmp 3930 3 kg kg NNP cord-015306-us58wwmp 3930 4 / / SYM cord-015306-us58wwmp 3930 5 day day NN cord-015306-us58wwmp 3930 6 , , , cord-015306-us58wwmp 3930 7 P p NN cord-015306-us58wwmp 3930 8 < < XX cord-015306-us58wwmp 3930 9 0.001 0.001 CD cord-015306-us58wwmp 3930 10 ) ) -RRB- cord-015306-us58wwmp 3930 11 . . . cord-015306-us58wwmp 3931 1 In in IN cord-015306-us58wwmp 3931 2 children child NNS cord-015306-us58wwmp 3931 3 receiving receive VBG cord-015306-us58wwmp 3931 4 steroids steroid NNS cord-015306-us58wwmp 3931 5 without without IN cord-015306-us58wwmp 3931 6 azoles azole NNS cord-015306-us58wwmp 3931 7 the the DT cord-015306-us58wwmp 3931 8 TAC TAC NNP cord-015306-us58wwmp 3931 9 Co Co NNP cord-015306-us58wwmp 3931 10 / / SYM cord-015306-us58wwmp 3931 11 D D NNP cord-015306-us58wwmp 3931 12 was be VBD cord-015306-us58wwmp 3931 13 significantly significantly RB cord-015306-us58wwmp 3931 14 different different JJ cord-015306-us58wwmp 3931 15 between between IN cord-015306-us58wwmp 3931 16 the the DT cord-015306-us58wwmp 3931 17 CYP3A5 CYP3A5 NNP cord-015306-us58wwmp 3931 18 * * NFP cord-015306-us58wwmp 3931 19 1/*3and 1/*3and CD cord-015306-us58wwmp 3931 20 CYP3A5 CYP3A5 NNP cord-015306-us58wwmp 3931 21 * * NFP cord-015306-us58wwmp 3931 22 3/*3 3/*3 CD cord-015306-us58wwmp 3931 23 genotypes genotype NNS cord-015306-us58wwmp 3931 24 , , , cord-015306-us58wwmp 3931 25 respectively respectively RB cord-015306-us58wwmp 3931 26 ( ( -LRB- cord-015306-us58wwmp 3931 27 52.86 52.86 CD cord-015306-us58wwmp 3931 28 + + SYM cord-015306-us58wwmp 3931 29 /-1.71 /-1.71 CD cord-015306-us58wwmp 3931 30 vs. vs. CC cord-015306-us58wwmp 3931 31 58.68 58.68 CD cord-015306-us58wwmp 3931 32 + + CC cord-015306-us58wwmp 3931 33 /-0.85 /-0.85 CD cord-015306-us58wwmp 3931 34 ng ng NNP cord-015306-us58wwmp 3931 35 / / SYM cord-015306-us58wwmp 3931 36 ml ml NNP cord-015306-us58wwmp 3931 37 / / SYM cord-015306-us58wwmp 3931 38 mg mg NNP cord-015306-us58wwmp 3931 39 / / SYM cord-015306-us58wwmp 3931 40 kg kg NNP cord-015306-us58wwmp 3931 41 / / SYM cord-015306-us58wwmp 3931 42 day day NN cord-015306-us58wwmp 3931 43 , , , cord-015306-us58wwmp 3931 44 P=0.0044 P=0.0044 NNP cord-015306-us58wwmp 3931 45 ) ) -RRB- cord-015306-us58wwmp 3931 46 but but CC cord-015306-us58wwmp 3932 1 the the DT cord-015306-us58wwmp 3932 2 TAC TAC NNP cord-015306-us58wwmp 3932 3 Co Co NNP cord-015306-us58wwmp 3932 4 / / SYM cord-015306-us58wwmp 3932 5 D D NNP cord-015306-us58wwmp 3932 6 was be VBD cord-015306-us58wwmp 3932 7 not not RB cord-015306-us58wwmp 3932 8 different different JJ cord-015306-us58wwmp 3932 9 for for IN cord-015306-us58wwmp 3932 10 those those DT cord-015306-us58wwmp 3932 11 receiving receive VBG cord-015306-us58wwmp 3932 12 steroid steroid NN cord-015306-us58wwmp 3932 13 versus versus IN cord-015306-us58wwmp 3932 14 those those DT cord-015306-us58wwmp 3932 15 not not RB cord-015306-us58wwmp 3932 16 receiving receive VBG cord-015306-us58wwmp 3932 17 steroid steroid NN cord-015306-us58wwmp 3932 18 with with IN cord-015306-us58wwmp 3932 19 CYP3A5 CYP3A5 NNP cord-015306-us58wwmp 3932 20 * * NFP cord-015306-us58wwmp 3932 21 3/*3 3/*3 CD cord-015306-us58wwmp 3932 22 genotype genotype NN cord-015306-us58wwmp 3932 23 ( ( -LRB- cord-015306-us58wwmp 3932 24 84.91 84.91 CD cord-015306-us58wwmp 3932 25 + + SYM cord-015306-us58wwmp 3932 26 /-12.7 /-12.7 NN cord-015306-us58wwmp 3932 27 and and CC cord-015306-us58wwmp 3932 28 84.21 84.21 CD cord-015306-us58wwmp 3933 1 + + CC cord-015306-us58wwmp 3933 2 /-1.41 /-1.41 CD cord-015306-us58wwmp 3933 3 ng ng NNP cord-015306-us58wwmp 3933 4 / / SYM cord-015306-us58wwmp 3933 5 ml ml NNP cord-015306-us58wwmp 3933 6 / / SYM cord-015306-us58wwmp 3933 7 mg mg NNP cord-015306-us58wwmp 3933 8 / / SYM cord-015306-us58wwmp 3933 9 kg kg NNP cord-015306-us58wwmp 3933 10 / / SYM cord-015306-us58wwmp 3933 11 day day NN cord-015306-us58wwmp 3933 12 , , , cord-015306-us58wwmp 3933 13 P=0.16 P=0.16 NNP cord-015306-us58wwmp 3933 14 ) ) -RRB- cord-015306-us58wwmp 3933 15 . . . cord-015306-us58wwmp 3934 1 Conclusion conclusion NN cord-015306-us58wwmp 3934 2 : : : cord-015306-us58wwmp 3935 1 In in IN cord-015306-us58wwmp 3935 2 conclusion conclusion NN cord-015306-us58wwmp 3935 3 , , , cord-015306-us58wwmp 3935 4 the the DT cord-015306-us58wwmp 3935 5 TAC TAC NNP cord-015306-us58wwmp 3935 6 dose dose NN cord-015306-us58wwmp 3935 7 is be VBZ cord-015306-us58wwmp 3935 8 influenced influence VBN cord-015306-us58wwmp 3935 9 by by IN cord-015306-us58wwmp 3935 10 the the DT cord-015306-us58wwmp 3935 11 CYP3A5 CYP3A5 NNP cord-015306-us58wwmp 3935 12 genotype genotype NN cord-015306-us58wwmp 3935 13 and and CC cord-015306-us58wwmp 3935 14 drugs drug NNS cord-015306-us58wwmp 3935 15 such such JJ cord-015306-us58wwmp 3935 16 as as IN cord-015306-us58wwmp 3935 17 azoles azole NNS cord-015306-us58wwmp 3935 18 , , , cord-015306-us58wwmp 3935 19 while while IN cord-015306-us58wwmp 3935 20 steroids steroid NNS cord-015306-us58wwmp 3935 21 may may MD cord-015306-us58wwmp 3935 22 not not RB cord-015306-us58wwmp 3935 23 impact impact VB cord-015306-us58wwmp 3935 24 TAC TAC NNP cord-015306-us58wwmp 3935 25 dose dose NN cord-015306-us58wwmp 3935 26 . . . cord-015306-us58wwmp 3936 1 While while IN cord-015306-us58wwmp 3936 2 therapeutic therapeutic JJ cord-015306-us58wwmp 3936 3 drug drug NN cord-015306-us58wwmp 3936 4 monitoring monitoring NN cord-015306-us58wwmp 3936 5 of of IN cord-015306-us58wwmp 3936 6 TAC TAC NNP cord-015306-us58wwmp 3936 7 remains remain VBZ cord-015306-us58wwmp 3936 8 necessary necessary JJ cord-015306-us58wwmp 3936 9 , , , cord-015306-us58wwmp 3936 10 integrated integrated JJ cord-015306-us58wwmp 3936 11 knowledge knowledge NN cord-015306-us58wwmp 3936 12 of of IN cord-015306-us58wwmp 3936 13 patient patient NN cord-015306-us58wwmp 3936 14 genotype genotype NN cord-015306-us58wwmp 3936 15 and and CC cord-015306-us58wwmp 3936 16 comedication comedication NN cord-015306-us58wwmp 3936 17 use use NN cord-015306-us58wwmp 3936 18 provides provide VBZ cord-015306-us58wwmp 3936 19 the the DT cord-015306-us58wwmp 3936 20 opportunity opportunity NN cord-015306-us58wwmp 3936 21 to to TO cord-015306-us58wwmp 3936 22 refine refine VB cord-015306-us58wwmp 3936 23 TAC TAC NNP cord-015306-us58wwmp 3936 24 dosing dosing NN cord-015306-us58wwmp 3936 25 in in IN cord-015306-us58wwmp 3936 26 children child NNS cord-015306-us58wwmp 3936 27 receiving receive VBG cord-015306-us58wwmp 3936 28 kidney kidney NN cord-015306-us58wwmp 3936 29 transplant transplant NN cord-015306-us58wwmp 3936 30 . . . cord-015306-us58wwmp 3937 1 Abstract abstract JJ cord-015306-us58wwmp 3937 2 # # NN cord-015306-us58wwmp 3937 3 P p NN cord-015306-us58wwmp 3937 4 - - HYPH cord-015306-us58wwmp 3937 5 SAT458 sat458 NN cord-015306-us58wwmp 3938 1 Basiliximab basiliximab JJ cord-015306-us58wwmp 3938 2 induction induction NN cord-015306-us58wwmp 3938 3 therapy therapy NN cord-015306-us58wwmp 3938 4 in in IN cord-015306-us58wwmp 3938 5 pediatric pediatric JJ cord-015306-us58wwmp 3938 6 renal renal JJ cord-015306-us58wwmp 3938 7 transplantation transplantation NN cord-015306-us58wwmp 3938 8 , , , cord-015306-us58wwmp 3938 9 A a DT cord-015306-us58wwmp 3938 10 double double JJ cord-015306-us58wwmp 3938 11 blind blind JJ cord-015306-us58wwmp 3938 12 clinical clinical JJ cord-015306-us58wwmp 3938 13 trial trial NN cord-015306-us58wwmp 3938 14 Hasan Hasan NNP cord-015306-us58wwmp 3938 15 Otukesh Otukesh NNP cord-015306-us58wwmp 3938 16 Tehran Tehran NNP cord-015306-us58wwmp 3938 17 university university NN cord-015306-us58wwmp 3938 18 of of IN cord-015306-us58wwmp 3938 19 medical medical JJ cord-015306-us58wwmp 3938 20 science science NN cord-015306-us58wwmp 3938 21 , , , cord-015306-us58wwmp 3938 22 associated associated JJ cord-015306-us58wwmp 3938 23 professor professor NN cord-015306-us58wwmp 3938 24 , , , cord-015306-us58wwmp 3938 25 Tehran Tehran NNP cord-015306-us58wwmp 3938 26 , , , cord-015306-us58wwmp 3938 27 Iran Iran NNP cord-015306-us58wwmp 3939 1 This this DT cord-015306-us58wwmp 3939 2 is be VBZ cord-015306-us58wwmp 3939 3 an an DT cord-015306-us58wwmp 3939 4 open open JJ cord-015306-us58wwmp 3939 5 , , , cord-015306-us58wwmp 3939 6 single single JJ cord-015306-us58wwmp 3939 7 center center NN cord-015306-us58wwmp 3939 8 , , , cord-015306-us58wwmp 3939 9 randomized randomized JJ cord-015306-us58wwmp 3939 10 study study NN cord-015306-us58wwmp 3939 11 to to TO cord-015306-us58wwmp 3939 12 compare compare VB cord-015306-us58wwmp 3939 13 induction induction NN cord-015306-us58wwmp 3939 14 therapy therapy NN cord-015306-us58wwmp 3939 15 with with IN cord-015306-us58wwmp 3939 16 basilixamb basilixamb NNP cord-015306-us58wwmp 3939 17 with with IN cord-015306-us58wwmp 3939 18 no no DT cord-015306-us58wwmp 3939 19 induction induction NN cord-015306-us58wwmp 3939 20 therapy therapy NN cord-015306-us58wwmp 3939 21 in in IN cord-015306-us58wwmp 3939 22 children child NNS cord-015306-us58wwmp 3939 23 with with IN cord-015306-us58wwmp 3939 24 renal renal JJ cord-015306-us58wwmp 3939 25 living living NN cord-015306-us58wwmp 3939 26 transplantation transplantation NN cord-015306-us58wwmp 3939 27 . . . cord-015306-us58wwmp 3940 1 In in IN cord-015306-us58wwmp 3940 2 this this DT cord-015306-us58wwmp 3940 3 trial trial NN cord-015306-us58wwmp 3940 4 20 20 CD cord-015306-us58wwmp 3940 5 pediatric pediatric JJ cord-015306-us58wwmp 3940 6 renal renal JJ cord-015306-us58wwmp 3940 7 transplant transplant NN cord-015306-us58wwmp 3940 8 recipients recipient NNS cord-015306-us58wwmp 3940 9 enrolled enrol VBN cord-015306-us58wwmp 3940 10 randomly randomly RB cord-015306-us58wwmp 3940 11 to to IN cord-015306-us58wwmp 3940 12 one one CD cord-015306-us58wwmp 3940 13 group group NN cord-015306-us58wwmp 3940 14 with with IN cord-015306-us58wwmp 3940 15 basiliximab basiliximab NNP cord-015306-us58wwmp 3940 16 as as IN cord-015306-us58wwmp 3940 17 induction induction NN cord-015306-us58wwmp 3940 18 therapy therapy NN cord-015306-us58wwmp 3940 19 and and CC cord-015306-us58wwmp 3940 20 another another DT cord-015306-us58wwmp 3940 21 group group NN cord-015306-us58wwmp 3940 22 without without IN cord-015306-us58wwmp 3940 23 basiliximab basiliximab NNP cord-015306-us58wwmp 3940 24 induction induction NN cord-015306-us58wwmp 3940 25 therapy therapy NN cord-015306-us58wwmp 3940 26 . . . cord-015306-us58wwmp 3941 1 Both both DT cord-015306-us58wwmp 3941 2 group group NN cord-015306-us58wwmp 3941 3 received receive VBD cord-015306-us58wwmp 3941 4 prednisolone prednisolone NN cord-015306-us58wwmp 3941 5 , , , cord-015306-us58wwmp 3941 6 cyclosporine cyclosporine NN cord-015306-us58wwmp 3941 7 and and CC cord-015306-us58wwmp 3941 8 cellcept cellcept NNP cord-015306-us58wwmp 3941 9 . . . cord-015306-us58wwmp 3942 1 We -PRON- PRP cord-015306-us58wwmp 3942 2 assessed assess VBD cord-015306-us58wwmp 3942 3 graft graft NN cord-015306-us58wwmp 3942 4 function function NN cord-015306-us58wwmp 3942 5 at at IN cord-015306-us58wwmp 3942 6 3 3 CD cord-015306-us58wwmp 3942 7 months month NNS cord-015306-us58wwmp 3942 8 after after IN cord-015306-us58wwmp 3942 9 transplant transplant NN cord-015306-us58wwmp 3942 10 and and CC cord-015306-us58wwmp 3942 11 compared compare VBD cord-015306-us58wwmp 3942 12 this this DT cord-015306-us58wwmp 3942 13 item item NN cord-015306-us58wwmp 3942 14 between between IN cord-015306-us58wwmp 3942 15 these these DT cord-015306-us58wwmp 3942 16 two two CD cord-015306-us58wwmp 3942 17 groups group NNS cord-015306-us58wwmp 3942 18 . . . cord-015306-us58wwmp 3943 1 In in IN cord-015306-us58wwmp 3943 2 the the DT cord-015306-us58wwmp 3943 3 congress congress NNP cord-015306-us58wwmp 3943 4 the the DT cord-015306-us58wwmp 3943 5 data datum NNS cord-015306-us58wwmp 3943 6 and and CC cord-015306-us58wwmp 3943 7 results result NNS cord-015306-us58wwmp 3943 8 of of IN cord-015306-us58wwmp 3943 9 this this DT cord-015306-us58wwmp 3943 10 randomized randomized JJ cord-015306-us58wwmp 3943 11 trial trial NN cord-015306-us58wwmp 3943 12 will will MD cord-015306-us58wwmp 3943 13 be be VB cord-015306-us58wwmp 3943 14 presented present VBN cord-015306-us58wwmp 3943 15 . . . cord-015306-us58wwmp 3944 1 Abstract abstract JJ cord-015306-us58wwmp 3944 2 # # NN cord-015306-us58wwmp 3944 3 P p NN cord-015306-us58wwmp 3944 4 - - HYPH cord-015306-us58wwmp 3944 5 SAT459 SAT459 NNP cord-015306-us58wwmp 3944 6 Legalization Legalization NNP cord-015306-us58wwmp 3944 7 of of IN cord-015306-us58wwmp 3944 8 the the DT cord-015306-us58wwmp 3944 9 organ organ NN cord-015306-us58wwmp 3944 10 donation donation NN cord-015306-us58wwmp 3944 11 and and CC cord-015306-us58wwmp 3944 12 optimal optimal JJ cord-015306-us58wwmp 3944 13 utilization utilization NN cord-015306-us58wwmp 3944 14 of of IN cord-015306-us58wwmp 3944 15 young young JJ cord-015306-us58wwmp 3944 16 pediatric pediatric JJ cord-015306-us58wwmp 3944 17 donor donor NN cord-015306-us58wwmp 3944 18 kidneys kidney NNS cord-015306-us58wwmp 3944 19 into into IN cord-015306-us58wwmp 3944 20 pediatric pediatric JJ cord-015306-us58wwmp 3944 21 recipients recipient NNS cord-015306-us58wwmp 3944 22 in in IN cord-015306-us58wwmp 3944 23 China China NNP cord-015306-us58wwmp 3944 24 Objective Objective NNP cord-015306-us58wwmp 3945 1 : : : cord-015306-us58wwmp 3945 2 China China NNP cord-015306-us58wwmp 3945 3 has have VBZ cord-015306-us58wwmp 3945 4 started start VBN cord-015306-us58wwmp 3945 5 to to TO cord-015306-us58wwmp 3945 6 establish establish VB cord-015306-us58wwmp 3945 7 a a DT cord-015306-us58wwmp 3945 8 new new JJ cord-015306-us58wwmp 3945 9 national national JJ cord-015306-us58wwmp 3945 10 system system NN cord-015306-us58wwmp 3945 11 for for IN cord-015306-us58wwmp 3945 12 organ organ NN cord-015306-us58wwmp 3945 13 donation donation NN cord-015306-us58wwmp 3945 14 and and CC cord-015306-us58wwmp 3945 15 transplantation transplantation NN cord-015306-us58wwmp 3945 16 since since IN cord-015306-us58wwmp 3945 17 March March NNP cord-015306-us58wwmp 3945 18 2010 2010 CD cord-015306-us58wwmp 3945 19 by by IN cord-015306-us58wwmp 3945 20 the the DT cord-015306-us58wwmp 3945 21 Ministry Ministry NNP cord-015306-us58wwmp 3945 22 of of IN cord-015306-us58wwmp 3945 23 Health Health NNP cord-015306-us58wwmp 3945 24 and and CC cord-015306-us58wwmp 3945 25 the the DT cord-015306-us58wwmp 3945 26 Red Red NNP cord-015306-us58wwmp 3945 27 Cross Cross NNP cord-015306-us58wwmp 3945 28 Society Society NNP cord-015306-us58wwmp 3945 29 of of IN cord-015306-us58wwmp 3945 30 China China NNP cord-015306-us58wwmp 3945 31 . . . cord-015306-us58wwmp 3946 1 The the DT cord-015306-us58wwmp 3946 2 aim aim NN cord-015306-us58wwmp 3946 3 of of IN cord-015306-us58wwmp 3946 4 this this DT cord-015306-us58wwmp 3946 5 study study NN cord-015306-us58wwmp 3946 6 was be VBD cord-015306-us58wwmp 3946 7 to to TO cord-015306-us58wwmp 3946 8 describe describe VB cord-015306-us58wwmp 3946 9 our -PRON- PRP$ cord-015306-us58wwmp 3946 10 initial initial JJ cord-015306-us58wwmp 3946 11 experience experience NN cord-015306-us58wwmp 3946 12 of of IN cord-015306-us58wwmp 3946 13 pediatric pediatric JJ cord-015306-us58wwmp 3946 14 renal renal JJ cord-015306-us58wwmp 3946 15 transplantation transplantation NN cord-015306-us58wwmp 3946 16 using use VBG cord-015306-us58wwmp 3946 17 organ organ NN cord-015306-us58wwmp 3946 18 donations donation NNS cord-015306-us58wwmp 3946 19 from from IN cord-015306-us58wwmp 3946 20 pediatric pediatric JJ cord-015306-us58wwmp 3946 21 patients patient NNS cord-015306-us58wwmp 3946 22 no no DT cord-015306-us58wwmp 3946 23 more more JJR cord-015306-us58wwmp 3946 24 than than IN cord-015306-us58wwmp 3946 25 6 6 CD cord-015306-us58wwmp 3946 26 years year NNS cord-015306-us58wwmp 3946 27 old old JJ cord-015306-us58wwmp 3946 28 . . . cord-015306-us58wwmp 3947 1 Methods method NNS cord-015306-us58wwmp 3947 2 : : : cord-015306-us58wwmp 3948 1 The the DT cord-015306-us58wwmp 3948 2 procedure procedure NN cord-015306-us58wwmp 3948 3 of of IN cord-015306-us58wwmp 3948 4 organ organ NN cord-015306-us58wwmp 3948 5 donation donation NN cord-015306-us58wwmp 3948 6 includes include VBZ cord-015306-us58wwmp 3948 7 : : : cord-015306-us58wwmp 3949 1 1 1 LS cord-015306-us58wwmp 3949 2 . . . cord-015306-us58wwmp 3950 1 Judgment judgment NN cord-015306-us58wwmp 3950 2 of of IN cord-015306-us58wwmp 3950 3 brain brain NN cord-015306-us58wwmp 3950 4 death death NN cord-015306-us58wwmp 3950 5 , , , cord-015306-us58wwmp 3950 6 or or CC cord-015306-us58wwmp 3950 7 circulatory circulatory JJ cord-015306-us58wwmp 3950 8 death death NN cord-015306-us58wwmp 3950 9 , , , cord-015306-us58wwmp 3950 10 or or CC cord-015306-us58wwmp 3950 11 brain brain NN cord-015306-us58wwmp 3950 12 death death NN cord-015306-us58wwmp 3950 13 followed follow VBN cord-015306-us58wwmp 3950 14 by by IN cord-015306-us58wwmp 3950 15 circulatory circulatory JJ cord-015306-us58wwmp 3950 16 death death NN cord-015306-us58wwmp 3950 17 by by IN cord-015306-us58wwmp 3950 18 doctors doctor NNS cord-015306-us58wwmp 3950 19 ; ; : cord-015306-us58wwmp 3950 20 2 2 CD cord-015306-us58wwmp 3950 21 . . . cord-015306-us58wwmp 3951 1 Organ organ NN cord-015306-us58wwmp 3951 2 donation donation NN cord-015306-us58wwmp 3951 3 informed inform VBD cord-015306-us58wwmp 3951 4 consent consent NN cord-015306-us58wwmp 3951 5 form form NN cord-015306-us58wwmp 3951 6 signed sign VBN cord-015306-us58wwmp 3951 7 by by IN cord-015306-us58wwmp 3951 8 family family NN cord-015306-us58wwmp 3951 9 ( ( -LRB- cord-015306-us58wwmp 3951 10 children child NNS cord-015306-us58wwmp 3951 11 's 's POS cord-015306-us58wwmp 3951 12 parents parent NNS cord-015306-us58wwmp 3951 13 ) ) -RRB- cord-015306-us58wwmp 3951 14 ; ; : cord-015306-us58wwmp 3951 15 3 3 CD cord-015306-us58wwmp 3951 16 . . . cord-015306-us58wwmp 3952 1 Approval approval NN cord-015306-us58wwmp 3952 2 by by IN cord-015306-us58wwmp 3952 3 the the DT cord-015306-us58wwmp 3952 4 hospital hospital NN cord-015306-us58wwmp 3952 5 Ethics Ethics NNP cord-015306-us58wwmp 3952 6 Committee Committee NNP cord-015306-us58wwmp 3952 7 ; ; : cord-015306-us58wwmp 3952 8 4.Organ 4.organ CD cord-015306-us58wwmp 3952 9 donation donation NN cord-015306-us58wwmp 3952 10 to to IN cord-015306-us58wwmp 3952 11 the the DT cord-015306-us58wwmp 3952 12 Red Red NNP cord-015306-us58wwmp 3952 13 Cross Cross NNP cord-015306-us58wwmp 3952 14 Society Society NNP cord-015306-us58wwmp 3952 15 and and CC cord-015306-us58wwmp 3952 16 allocation allocation NN cord-015306-us58wwmp 3952 17 by by IN cord-015306-us58wwmp 3952 18 the the DT cord-015306-us58wwmp 3952 19 China China NNP cord-015306-us58wwmp 3952 20 Organ Organ NNP cord-015306-us58wwmp 3952 21 Transplant Transplant NNP cord-015306-us58wwmp 3952 22 Response Response NNP cord-015306-us58wwmp 3952 23 System System NNP cord-015306-us58wwmp 3952 24 ( ( -LRB- cord-015306-us58wwmp 3952 25 COTRS COTRS NNP cord-015306-us58wwmp 3952 26 ) ) -RRB- cord-015306-us58wwmp 3952 27 . . . cord-015306-us58wwmp 3953 1 The the DT cord-015306-us58wwmp 3953 2 Red Red NNP cord-015306-us58wwmp 3953 3 Cross Cross NNP cord-015306-us58wwmp 3953 4 Society Society NNP cord-015306-us58wwmp 3953 5 has have VBZ cord-015306-us58wwmp 3953 6 been be VBN cord-015306-us58wwmp 3953 7 commissioned commission VBN cord-015306-us58wwmp 3953 8 by by IN cord-015306-us58wwmp 3953 9 the the DT cord-015306-us58wwmp 3953 10 Ministry Ministry NNP cord-015306-us58wwmp 3953 11 of of IN cord-015306-us58wwmp 3953 12 Health Health NNP cord-015306-us58wwmp 3953 13 to to TO cord-015306-us58wwmp 3953 14 run run VB cord-015306-us58wwmp 3953 15 this this DT cord-015306-us58wwmp 3953 16 system system NN cord-015306-us58wwmp 3953 17 . . . cord-015306-us58wwmp 3954 1 Clinical clinical JJ cord-015306-us58wwmp 3954 2 data datum NNS cord-015306-us58wwmp 3954 3 of of IN cord-015306-us58wwmp 3954 4 8 8 CD cord-015306-us58wwmp 3954 5 children child NNS cord-015306-us58wwmp 3954 6 who who WP cord-015306-us58wwmp 3954 7 underwent undergo VBD cord-015306-us58wwmp 3954 8 renal renal JJ cord-015306-us58wwmp 3954 9 transplantation transplantation NN cord-015306-us58wwmp 3954 10 using use VBG cord-015306-us58wwmp 3954 11 organ organ NN cord-015306-us58wwmp 3954 12 donations donation NNS cord-015306-us58wwmp 3954 13 from from IN cord-015306-us58wwmp 3954 14 pediatric pediatric JJ cord-015306-us58wwmp 3954 15 patients patient NNS cord-015306-us58wwmp 3954 16 no no DT cord-015306-us58wwmp 3954 17 more more JJR cord-015306-us58wwmp 3954 18 than than IN cord-015306-us58wwmp 3954 19 6 6 CD cord-015306-us58wwmp 3954 20 years year NNS cord-015306-us58wwmp 3954 21 between between IN cord-015306-us58wwmp 3954 22 September September NNP cord-015306-us58wwmp 3954 23 2011 2011 CD cord-015306-us58wwmp 3954 24 and and CC cord-015306-us58wwmp 3954 25 March March NNP cord-015306-us58wwmp 3954 26 2013 2013 CD cord-015306-us58wwmp 3954 27 were be VBD cord-015306-us58wwmp 3954 28 retrospectively retrospectively RB cord-015306-us58wwmp 3954 29 analyzed analyze VBN cord-015306-us58wwmp 3954 30 . . . cord-015306-us58wwmp 3955 1 Results result NNS cord-015306-us58wwmp 3955 2 : : : cord-015306-us58wwmp 3956 1 The the DT cord-015306-us58wwmp 3956 2 age age NN cord-015306-us58wwmp 3956 3 at at IN cord-015306-us58wwmp 3956 4 transplantation transplantation NN cord-015306-us58wwmp 3956 5 for for IN cord-015306-us58wwmp 3956 6 these these DT cord-015306-us58wwmp 3956 7 8 8 CD cord-015306-us58wwmp 3956 8 patients patient NNS cord-015306-us58wwmp 3956 9 was be VBD cord-015306-us58wwmp 3956 10 4.5 4.5 CD cord-015306-us58wwmp 3956 11 years year NNS cord-015306-us58wwmp 3956 12 to to IN cord-015306-us58wwmp 3956 13 14 14 CD cord-015306-us58wwmp 3956 14 years year NNS cord-015306-us58wwmp 3956 15 and and CC cord-015306-us58wwmp 3956 16 the the DT cord-015306-us58wwmp 3956 17 weight weight NN cord-015306-us58wwmp 3956 18 was be VBD cord-015306-us58wwmp 3956 19 14 14 CD cord-015306-us58wwmp 3956 20 kg kg NNS cord-015306-us58wwmp 3956 21 to to IN cord-015306-us58wwmp 3956 22 35 35 CD cord-015306-us58wwmp 3956 23 kg kg NNS cord-015306-us58wwmp 3956 24 . . . cord-015306-us58wwmp 3957 1 Among among IN cord-015306-us58wwmp 3957 2 these these DT cord-015306-us58wwmp 3957 3 8 8 CD cord-015306-us58wwmp 3957 4 cases case NNS cord-015306-us58wwmp 3957 5 , , , cord-015306-us58wwmp 3957 6 7 7 CD cord-015306-us58wwmp 3957 7 donors donor NNS cord-015306-us58wwmp 3957 8 were be VBD cord-015306-us58wwmp 3957 9 used use VBN cord-015306-us58wwmp 3957 10 aged aged JJ cord-015306-us58wwmp 3957 11 from from IN cord-015306-us58wwmp 3957 12 33 33 CD cord-015306-us58wwmp 3957 13 days day NNS cord-015306-us58wwmp 3957 14 to to IN cord-015306-us58wwmp 3957 15 6 6 CD cord-015306-us58wwmp 3957 16 years year NNS cord-015306-us58wwmp 3957 17 and and CC cord-015306-us58wwmp 3957 18 all all DT cord-015306-us58wwmp 3957 19 diagnosed diagnose VBN cord-015306-us58wwmp 3957 20 with with IN cord-015306-us58wwmp 3957 21 circulatory circulatory JJ cord-015306-us58wwmp 3957 22 death death NN cord-015306-us58wwmp 3957 23 . . . cord-015306-us58wwmp 3958 1 5 5 CD cord-015306-us58wwmp 3958 2 recipients recipient NNS cord-015306-us58wwmp 3958 3 received receive VBN cord-015306-us58wwmp 3958 4 en en IN cord-015306-us58wwmp 3958 5 bloc bloc NNP cord-015306-us58wwmp 3958 6 kidney kidney NN cord-015306-us58wwmp 3958 7 transplantation transplantation NN cord-015306-us58wwmp 3958 8 and and CC cord-015306-us58wwmp 3958 9 the the DT cord-015306-us58wwmp 3958 10 other other JJ cord-015306-us58wwmp 3958 11 3 3 CD cord-015306-us58wwmp 3958 12 recipients recipient NNS cord-015306-us58wwmp 3958 13 received receive VBD cord-015306-us58wwmp 3958 14 one one CD cord-015306-us58wwmp 3958 15 single single JJ cord-015306-us58wwmp 3958 16 kidney kidney NN cord-015306-us58wwmp 3958 17 according accord VBG cord-015306-us58wwmp 3958 18 to to IN cord-015306-us58wwmp 3958 19 the the DT cord-015306-us58wwmp 3958 20 size size NN cord-015306-us58wwmp 3958 21 of of IN cord-015306-us58wwmp 3958 22 both both DT cord-015306-us58wwmp 3958 23 recipient recipient NN cord-015306-us58wwmp 3958 24 and and CC cord-015306-us58wwmp 3958 25 donor donor NN cord-015306-us58wwmp 3958 26 . . . cord-015306-us58wwmp 3959 1 The the DT cord-015306-us58wwmp 3959 2 duration duration NN cord-015306-us58wwmp 3959 3 of of IN cord-015306-us58wwmp 3959 4 follow follow NN cord-015306-us58wwmp 3959 5 - - HYPH cord-015306-us58wwmp 3959 6 up up NN cord-015306-us58wwmp 3959 7 after after IN cord-015306-us58wwmp 3959 8 the the DT cord-015306-us58wwmp 3959 9 transplantation transplantation NN cord-015306-us58wwmp 3959 10 was be VBD cord-015306-us58wwmp 3959 11 1 1 CD cord-015306-us58wwmp 3959 12 month month NN cord-015306-us58wwmp 3959 13 to to IN cord-015306-us58wwmp 3959 14 18 18 CD cord-015306-us58wwmp 3959 15 months month NNS cord-015306-us58wwmp 3959 16 . . . cord-015306-us58wwmp 3960 1 Patient patient JJ cord-015306-us58wwmp 3960 2 survival survival NN cord-015306-us58wwmp 3960 3 rate rate NN cord-015306-us58wwmp 3960 4 was be VBD cord-015306-us58wwmp 3960 5 100 100 CD cord-015306-us58wwmp 3960 6 % % NN cord-015306-us58wwmp 3960 7 and and CC cord-015306-us58wwmp 3960 8 graft graft NN cord-015306-us58wwmp 3960 9 survival survival NN cord-015306-us58wwmp 3960 10 rate rate NN cord-015306-us58wwmp 3960 11 was be VBD cord-015306-us58wwmp 3960 12 7/9 7/9 CD cord-015306-us58wwmp 3960 13 ( ( -LRB- cord-015306-us58wwmp 3960 14 77.8 77.8 CD cord-015306-us58wwmp 3960 15 % % NN cord-015306-us58wwmp 3960 16 , , , cord-015306-us58wwmp 3960 17 one one CD cord-015306-us58wwmp 3960 18 graft graft NN cord-015306-us58wwmp 3960 19 loss loss NN cord-015306-us58wwmp 3960 20 due due IN cord-015306-us58wwmp 3960 21 to to IN cord-015306-us58wwmp 3960 22 the the DT cord-015306-us58wwmp 3960 23 hemorrhagic hemorrhagic JJ cord-015306-us58wwmp 3960 24 complication complication NN cord-015306-us58wwmp 3960 25 and and CC cord-015306-us58wwmp 3960 26 the the DT cord-015306-us58wwmp 3960 27 other other JJ cord-015306-us58wwmp 3960 28 one one CD cord-015306-us58wwmp 3960 29 due due IN cord-015306-us58wwmp 3960 30 to to IN cord-015306-us58wwmp 3960 31 the the DT cord-015306-us58wwmp 3960 32 thrombosis thrombosis NN cord-015306-us58wwmp 3960 33 ) ) -RRB- cord-015306-us58wwmp 3960 34 . . . cord-015306-us58wwmp 3961 1 At at IN cord-015306-us58wwmp 3961 2 latest late JJS cord-015306-us58wwmp 3961 3 follow follow NN cord-015306-us58wwmp 3961 4 - - HYPH cord-015306-us58wwmp 3961 5 up up NN cord-015306-us58wwmp 3961 6 , , , cord-015306-us58wwmp 3961 7 the the DT cord-015306-us58wwmp 3961 8 median median JJ cord-015306-us58wwmp 3961 9 serum serum NN cord-015306-us58wwmp 3961 10 creatinine creatinine NN cord-015306-us58wwmp 3961 11 level level NN cord-015306-us58wwmp 3961 12 was be VBD cord-015306-us58wwmp 3962 1 92umol 92umol NNP cord-015306-us58wwmp 3962 2 / / SYM cord-015306-us58wwmp 3962 3 L L NNP cord-015306-us58wwmp 3962 4 and and CC cord-015306-us58wwmp 3962 5 the the DT cord-015306-us58wwmp 3962 6 median median NN cord-015306-us58wwmp 3962 7 eGFR egfr NN cord-015306-us58wwmp 3962 8 was be VBD cord-015306-us58wwmp 3962 9 80ml/(min·1.73 80ml/(min·1.73 CD cord-015306-us58wwmp 3962 10 m m CD cord-015306-us58wwmp 3962 11 2 2 CD cord-015306-us58wwmp 3962 12 ) ) -RRB- cord-015306-us58wwmp 3962 13 . . . cord-015306-us58wwmp 3963 1 Conclusion conclusion NN cord-015306-us58wwmp 3963 2 : : : cord-015306-us58wwmp 3964 1 Organ organ NN cord-015306-us58wwmp 3964 2 transplantation transplantation NN cord-015306-us58wwmp 3964 3 legislation legislation NN cord-015306-us58wwmp 3964 4 is be VBZ cord-015306-us58wwmp 3964 5 necessary necessary JJ cord-015306-us58wwmp 3964 6 to to TO cord-015306-us58wwmp 3964 7 ensure ensure VB cord-015306-us58wwmp 3964 8 the the DT cord-015306-us58wwmp 3964 9 rights right NNS cord-015306-us58wwmp 3964 10 and and CC cord-015306-us58wwmp 3964 11 obligations obligation NNS cord-015306-us58wwmp 3964 12 of of IN cord-015306-us58wwmp 3964 13 donors donor NNS cord-015306-us58wwmp 3964 14 , , , cord-015306-us58wwmp 3964 15 recipients recipient NNS cord-015306-us58wwmp 3964 16 and and CC cord-015306-us58wwmp 3964 17 medical medical JJ cord-015306-us58wwmp 3964 18 institutions institution NNS cord-015306-us58wwmp 3964 19 . . . cord-015306-us58wwmp 3965 1 We -PRON- PRP cord-015306-us58wwmp 3965 2 believe believe VBP cord-015306-us58wwmp 3965 3 young young JJ cord-015306-us58wwmp 3965 4 pediatric pediatric JJ cord-015306-us58wwmp 3965 5 donors donor NNS cord-015306-us58wwmp 3965 6 can can MD cord-015306-us58wwmp 3965 7 be be VB cord-015306-us58wwmp 3965 8 expanded expand VBN cord-015306-us58wwmp 3965 9 further further RB cord-015306-us58wwmp 3965 10 to to TO cord-015306-us58wwmp 3965 11 increase increase VB cord-015306-us58wwmp 3965 12 the the DT cord-015306-us58wwmp 3965 13 number number NN cord-015306-us58wwmp 3965 14 of of IN cord-015306-us58wwmp 3965 15 pediatric pediatric JJ cord-015306-us58wwmp 3965 16 renal renal JJ cord-015306-us58wwmp 3965 17 transplants transplant NNS cord-015306-us58wwmp 3965 18 . . . cord-015306-us58wwmp 3966 1 This this DT cord-015306-us58wwmp 3966 2 pediatric pediatric JJ cord-015306-us58wwmp 3966 3 to to IN cord-015306-us58wwmp 3966 4 pediatric pediatric JJ cord-015306-us58wwmp 3966 5 combination combination NN cord-015306-us58wwmp 3966 6 on on IN cord-015306-us58wwmp 3966 7 the the DT cord-015306-us58wwmp 3966 8 one one CD cord-015306-us58wwmp 3966 9 hand hand NN cord-015306-us58wwmp 3966 10 efficiently efficiently RB cord-015306-us58wwmp 3966 11 lower lower VB cord-015306-us58wwmp 3966 12 the the DT cord-015306-us58wwmp 3966 13 discarding discard VBG cord-015306-us58wwmp 3966 14 ratio ratio NN cord-015306-us58wwmp 3966 15 of of IN cord-015306-us58wwmp 3966 16 the the DT cord-015306-us58wwmp 3966 17 kidneys kidney NNS cord-015306-us58wwmp 3966 18 from from IN cord-015306-us58wwmp 3966 19 small small JJ cord-015306-us58wwmp 3966 20 donor donor NN cord-015306-us58wwmp 3966 21 , , , cord-015306-us58wwmp 3966 22 and and CC cord-015306-us58wwmp 3966 23 give give VB cord-015306-us58wwmp 3966 24 more more JJR cord-015306-us58wwmp 3966 25 chances chance NNS cord-015306-us58wwmp 3966 26 to to IN cord-015306-us58wwmp 3966 27 the the DT cord-015306-us58wwmp 3966 28 younger young JJR cord-015306-us58wwmp 3966 29 recipient recipient NN cord-015306-us58wwmp 3966 30 on on IN cord-015306-us58wwmp 3966 31 the the DT cord-015306-us58wwmp 3966 32 other other JJ cord-015306-us58wwmp 3966 33 . . . cord-015306-us58wwmp 3967 1 To to TO cord-015306-us58wwmp 3967 2 assess assess VB cord-015306-us58wwmp 3967 3 the the DT cord-015306-us58wwmp 3967 4 normalization normalization NN cord-015306-us58wwmp 3967 5 of of IN cord-015306-us58wwmp 3967 6 serum serum NN cord-015306-us58wwmp 3967 7 25 25 CD cord-015306-us58wwmp 3967 8 ( ( -LRB- cord-015306-us58wwmp 3967 9 OH)D oh)d JJ cord-015306-us58wwmp 3967 10 level level NN cord-015306-us58wwmp 3967 11 ( ( -LRB- cord-015306-us58wwmp 3967 12 > > NFP cord-015306-us58wwmp 3967 13 30 30 CD cord-015306-us58wwmp 3967 14 ng ng NN cord-015306-us58wwmp 3967 15 / / SYM cord-015306-us58wwmp 3967 16 ml ml NN cord-015306-us58wwmp 3967 17 ) ) -RRB- cord-015306-us58wwmp 3967 18 after after IN cord-015306-us58wwmp 3967 19 standard standard JJ cord-015306-us58wwmp 3967 20 treatment treatment NN cord-015306-us58wwmp 3967 21 dosing dose VBG cord-015306-us58wwmp 3967 22 among among IN cord-015306-us58wwmp 3967 23 Primary primary JJ cord-015306-us58wwmp 3967 24 Hypertension hypertension NN cord-015306-us58wwmp 3967 25 ( ( -LRB- cord-015306-us58wwmp 3967 26 PH PH NNP cord-015306-us58wwmp 3967 27 ) ) -RRB- cord-015306-us58wwmp 3967 28 and and CC cord-015306-us58wwmp 3968 1 Chronic chronic JJ cord-015306-us58wwmp 3968 2 Kidney kidney NN cord-015306-us58wwmp 3968 3 disease disease NN cord-015306-us58wwmp 3968 4 ( ( -LRB- cord-015306-us58wwmp 3968 5 CKD CKD NNP cord-015306-us58wwmp 3968 6 ) ) -RRB- cord-015306-us58wwmp 3968 7 Methods Methods NNPS cord-015306-us58wwmp 3969 1 : : : cord-015306-us58wwmp 3969 2 We -PRON- PRP cord-015306-us58wwmp 3969 3 enrolled enrol VBD cord-015306-us58wwmp 3969 4 144 144 CD cord-015306-us58wwmp 3969 5 patients patient NNS cord-015306-us58wwmp 3969 6 aged aged JJ cord-015306-us58wwmp 3969 7 2 2 CD cord-015306-us58wwmp 3969 8 - - SYM cord-015306-us58wwmp 3969 9 19 19 CD cord-015306-us58wwmp 3969 10 yrs yr NNS cord-015306-us58wwmp 3969 11 We -PRON- PRP cord-015306-us58wwmp 3969 12 collected collect VBD cord-015306-us58wwmp 3969 13 retrospective retrospective JJ cord-015306-us58wwmp 3969 14 data datum NNS cord-015306-us58wwmp 3969 15 on on IN cord-015306-us58wwmp 3969 16 age age NN cord-015306-us58wwmp 3969 17 , , , cord-015306-us58wwmp 3969 18 sex sex NN cord-015306-us58wwmp 3969 19 , , , cord-015306-us58wwmp 3969 20 race race NN cord-015306-us58wwmp 3969 21 , , , cord-015306-us58wwmp 3969 22 cause cause NN cord-015306-us58wwmp 3969 23 of of IN cord-015306-us58wwmp 3969 24 kidney kidney NN cord-015306-us58wwmp 3969 25 disease disease NN cord-015306-us58wwmp 3969 26 , , , cord-015306-us58wwmp 3969 27 eGFR egfr NN cord-015306-us58wwmp 3969 28 , , , cord-015306-us58wwmp 3970 1 Ht Ht NNP cord-015306-us58wwmp 3970 2 , , , cord-015306-us58wwmp 3970 3 Wt Wt NNP cord-015306-us58wwmp 3970 4 , , , cord-015306-us58wwmp 3970 5 BMI BMI NNP cord-015306-us58wwmp 3970 6 , , , cord-015306-us58wwmp 3970 7 BP BP NNP cord-015306-us58wwmp 3970 8 z z NNP cord-015306-us58wwmp 3970 9 - - HYPH cord-015306-us58wwmp 3970 10 scores score NNS cord-015306-us58wwmp 3970 11 , , , cord-015306-us58wwmp 3970 12 lipid lipid NN cord-015306-us58wwmp 3970 13 panel panel NN cord-015306-us58wwmp 3970 14 , , , cord-015306-us58wwmp 3970 15 25(OH 25(oh CD cord-015306-us58wwmp 3970 16 ) ) -RRB- cord-015306-us58wwmp 3971 1 D d JJ cord-015306-us58wwmp 3971 2 level level NN cord-015306-us58wwmp 3971 3 , , , cord-015306-us58wwmp 3971 4 PTH PTH NNP cord-015306-us58wwmp 3971 5 , , , cord-015306-us58wwmp 3971 6 Calcium Calcium NNP cord-015306-us58wwmp 3971 7 , , , cord-015306-us58wwmp 3971 8 Phosphorus Phosphorus NNP cord-015306-us58wwmp 3971 9 , , , cord-015306-us58wwmp 3971 10 Magnesium magnesium NN cord-015306-us58wwmp 3971 11 , , , cord-015306-us58wwmp 3971 12 medications medication NNS cord-015306-us58wwmp 3971 13 , , , cord-015306-us58wwmp 3971 14 type type NN cord-015306-us58wwmp 3971 15 and and CC cord-015306-us58wwmp 3971 16 dosing dosing NN cord-015306-us58wwmp 3971 17 of of IN cord-015306-us58wwmp 3971 18 Vitamin vitamin NN cord-015306-us58wwmp 3971 19 D D NNP cord-015306-us58wwmp 3971 20 Supplements Supplements NNPS cord-015306-us58wwmp 3971 21 and and CC cord-015306-us58wwmp 3971 22 follow follow VB cord-015306-us58wwmp 3971 23 up up RP cord-015306-us58wwmp 3971 24 serum serum NN cord-015306-us58wwmp 3971 25 vitamin vitamin NN cord-015306-us58wwmp 3971 26 D d NN cord-015306-us58wwmp 3971 27 level level NN cord-015306-us58wwmp 3971 28 three three CD cord-015306-us58wwmp 3971 29 months month NNS cord-015306-us58wwmp 3971 30 post post NN cord-015306-us58wwmp 3971 31 treatment treatment NN cord-015306-us58wwmp 3971 32 . . . cord-015306-us58wwmp 3972 1 Results result NNS cord-015306-us58wwmp 3972 2 : : : cord-015306-us58wwmp 3973 1 Mean mean JJ cord-015306-us58wwmp 3973 2 age age NN cord-015306-us58wwmp 3973 3 ( ( -LRB- cord-015306-us58wwmp 3973 4 yrs yrs NN cord-015306-us58wwmp 3973 5 ) ) -RRB- cord-015306-us58wwmp 3973 6 was be VBD cord-015306-us58wwmp 3973 7 ( ( -LRB- cord-015306-us58wwmp 3973 8 12.99±5.05 12.99±5.05 CD cord-015306-us58wwmp 3973 9 ) ) -RRB- cord-015306-us58wwmp 3973 10 . . . cord-015306-us58wwmp 3974 1 white(2 white(2 NNP cord-015306-us58wwmp 3974 2 ) ) -RRB- cord-015306-us58wwmp 3975 1 Prevalence prevalence NN cord-015306-us58wwmp 3975 2 of of IN cord-015306-us58wwmp 3975 3 Vitamin vitamin NN cord-015306-us58wwmp 3975 4 D d NN cord-015306-us58wwmp 3975 5 deficiency deficiency NN cord-015306-us58wwmp 3975 6 was be VBD cord-015306-us58wwmp 3975 7 ( ( -LRB- cord-015306-us58wwmp 3975 8 88 88 CD cord-015306-us58wwmp 3975 9 % % NN cord-015306-us58wwmp 3975 10 ) ) -RRB- cord-015306-us58wwmp 3975 11 ; ; : cord-015306-us58wwmp 3975 12 60 60 CD cord-015306-us58wwmp 3975 13 % % NN cord-015306-us58wwmp 3975 14 had have VBD cord-015306-us58wwmp 3975 15 level level NN cord-015306-us58wwmp 3975 16 < < XX cord-015306-us58wwmp 3975 17 20 20 CD cord-015306-us58wwmp 3975 18 ng ng NNP cord-015306-us58wwmp 3975 19 / / SYM cord-015306-us58wwmp 3975 20 ml ml NN cord-015306-us58wwmp 3975 21 . . . cord-015306-us58wwmp 3976 1 Mean mean JJ cord-015306-us58wwmp 3976 2 pretreatment pretreatment NN cord-015306-us58wwmp 3976 3 25(OH 25(oh CD cord-015306-us58wwmp 3976 4 ) ) -RRB- cord-015306-us58wwmp 3977 1 D D NNP cord-015306-us58wwmp 3977 2 ( ( -LRB- cord-015306-us58wwmp 3977 3 ng ng NNP cord-015306-us58wwmp 3977 4 / / SYM cord-015306-us58wwmp 3977 5 ml ml NN cord-015306-us58wwmp 3977 6 ) ) -RRB- cord-015306-us58wwmp 3977 7 was be VBD cord-015306-us58wwmp 3977 8 ( ( -LRB- cord-015306-us58wwmp 3977 9 19.25±10.69 19.25±10.69 CD cord-015306-us58wwmp 3977 10 ) ) -RRB- cord-015306-us58wwmp 3978 1 After after IN cord-015306-us58wwmp 3978 2 completion completion NN cord-015306-us58wwmp 3978 3 of of IN cord-015306-us58wwmp 3978 4 standard standard JJ cord-015306-us58wwmp 3978 5 treatment treatment NN cord-015306-us58wwmp 3978 6 almost almost RB cord-015306-us58wwmp 3978 7 64 64 CD cord-015306-us58wwmp 3978 8 % % NN cord-015306-us58wwmp 3978 9 patients patient NNS cord-015306-us58wwmp 3978 10 had have VBD cord-015306-us58wwmp 3978 11 25 25 CD cord-015306-us58wwmp 3979 1 ( ( -LRB- cord-015306-us58wwmp 3979 2 OH oh UH cord-015306-us58wwmp 3979 3 ) ) -RRB- cord-015306-us58wwmp 3979 4 D d NN cord-015306-us58wwmp 3979 5 level level NN cord-015306-us58wwmp 3979 6 < < XX cord-015306-us58wwmp 3979 7 30 30 CD cord-015306-us58wwmp 3979 8 ng ng NN cord-015306-us58wwmp 3979 9 / / SYM cord-015306-us58wwmp 3979 10 ml ml NN cord-015306-us58wwmp 3979 11 ; ; : cord-015306-us58wwmp 3979 12 PH(28.02±9.22 ph(28.02±9.22 LS cord-015306-us58wwmp 3979 13 ) ) -RRB- cord-015306-us58wwmp 3980 1 and and CC cord-015306-us58wwmp 3980 2 CKD(25.38±9.8 CKD(25.38±9.8 NNP cord-015306-us58wwmp 3980 3 ) ) -RRB- cord-015306-us58wwmp 3980 4 . . . cord-015306-us58wwmp 3981 1 None none NN cord-015306-us58wwmp 3981 2 were be VBD cord-015306-us58wwmp 3981 3 in in IN cord-015306-us58wwmp 3981 4 toxic toxic JJ cord-015306-us58wwmp 3981 5 range range NN cord-015306-us58wwmp 3981 6 . . . cord-015306-us58wwmp 3982 1 Conclusion conclusion NN cord-015306-us58wwmp 3982 2 : : : cord-015306-us58wwmp 3983 1 The the DT cord-015306-us58wwmp 3983 2 standard standard JJ cord-015306-us58wwmp 3983 3 treatment treatment NN cord-015306-us58wwmp 3983 4 dose dose NN cord-015306-us58wwmp 3983 5 of of IN cord-015306-us58wwmp 3983 6 Vitamin vitamin NN cord-015306-us58wwmp 3983 7 D d NN cord-015306-us58wwmp 3983 8 doesn doesn NN cord-015306-us58wwmp 3983 9 Abstract abstract JJ cord-015306-us58wwmp 3983 10 # # NN cord-015306-us58wwmp 3983 11 P P NNP cord-015306-us58wwmp 3983 12 - - HYPH cord-015306-us58wwmp 3983 13 SAT360 SAT360 NNP cord-015306-us58wwmp 3983 14 Mineral mineral NN cord-015306-us58wwmp 3983 15 metabolism metabolism NN cord-015306-us58wwmp 3983 16 in in IN cord-015306-us58wwmp 3983 17 European european JJ cord-015306-us58wwmp 3983 18 children child NNS cord-015306-us58wwmp 3983 19 with with IN cord-015306-us58wwmp 3983 20 end end NN cord-015306-us58wwmp 3983 21 - - HYPH cord-015306-us58wwmp 3983 22 stage stage NN cord-015306-us58wwmp 3983 23 renal renal JJ cord-015306-us58wwmp 3983 24 disease disease NN cord-015306-us58wwmp 3983 25 Marjolein Marjolein NNP cord-015306-us58wwmp 3983 26 Bonthuis Bonthuis NNP cord-015306-us58wwmp 3983 27 1 1 CD cord-015306-us58wwmp 3984 1 The the DT cord-015306-us58wwmp 3984 2 Netherlands Netherlands NNP cord-015306-us58wwmp 3984 3 2 2 CD cord-015306-us58wwmp 3984 4 Pediatrics Pediatrics NNP cord-015306-us58wwmp 3984 5 , , , cord-015306-us58wwmp 3984 6 Nephrology Nephrology NNP cord-015306-us58wwmp 3984 7 and and CC cord-015306-us58wwmp 3984 8 Dialysis Dialysis NNP cord-015306-us58wwmp 3984 9 Unit Unit NNP cord-015306-us58wwmp 3984 10 Results result VBZ cord-015306-us58wwmp 3984 11 : : : cord-015306-us58wwmp 3984 12 Hypocalcaemia Hypocalcaemia NNP cord-015306-us58wwmp 3984 13 was be VBD cord-015306-us58wwmp 3984 14 found find VBN cord-015306-us58wwmp 3984 15 in in IN cord-015306-us58wwmp 3984 16 22 22 CD cord-015306-us58wwmp 3984 17 % % NN cord-015306-us58wwmp 3984 18 of of IN cord-015306-us58wwmp 3984 19 HD hd NN cord-015306-us58wwmp 3984 20 , , , cord-015306-us58wwmp 3984 21 18 18 CD cord-015306-us58wwmp 3984 22 % % NN cord-015306-us58wwmp 3984 23 of of IN cord-015306-us58wwmp 3984 24 PD PD NNP cord-015306-us58wwmp 3984 25 , , , cord-015306-us58wwmp 3984 26 and and CC cord-015306-us58wwmp 3984 27 48 48 CD cord-015306-us58wwmp 3984 28 % % NN cord-015306-us58wwmp 3984 29 of of IN cord-015306-us58wwmp 3984 30 transplanted transplanted JJ cord-015306-us58wwmp 3984 31 patients patient NNS cord-015306-us58wwmp 3984 32 , , , cord-015306-us58wwmp 3984 33 with with IN cord-015306-us58wwmp 3984 34 a a DT cord-015306-us58wwmp 3984 35 mean mean JJ cord-015306-us58wwmp 3984 36 time time NN cord-015306-us58wwmp 3984 37 on on IN cord-015306-us58wwmp 3984 38 transplantation transplantation NN cord-015306-us58wwmp 3984 39 of of IN cord-015306-us58wwmp 3984 40 4.3 4.3 CD cord-015306-us58wwmp 3984 41 years year NNS cord-015306-us58wwmp 3984 42 . . . cord-015306-us58wwmp 3985 1 Hyperphosphataemia Hyperphosphataemia NNP cord-015306-us58wwmp 3985 2 was be VBD cord-015306-us58wwmp 3985 3 found find VBN cord-015306-us58wwmp 3985 4 in in IN cord-015306-us58wwmp 3985 5 47 47 CD cord-015306-us58wwmp 3985 6 % % NN cord-015306-us58wwmp 3985 7 of of IN cord-015306-us58wwmp 3985 8 HD hd NN cord-015306-us58wwmp 3985 9 , , , cord-015306-us58wwmp 3985 10 37 37 CD cord-015306-us58wwmp 3985 11 % % NN cord-015306-us58wwmp 3985 12 of of IN cord-015306-us58wwmp 3985 13 PD PD NNP cord-015306-us58wwmp 3985 14 , , , cord-015306-us58wwmp 3985 15 and and CC cord-015306-us58wwmp 3985 16 5 5 CD cord-015306-us58wwmp 3985 17 % % NN cord-015306-us58wwmp 3985 18 of of IN cord-015306-us58wwmp 3985 19 transplanted transplanted JJ cord-015306-us58wwmp 3985 20 patients patient NNS cord-015306-us58wwmp 3985 21 . . . cord-015306-us58wwmp 3986 1 PTH PTH NNP cord-015306-us58wwmp 3986 2 was be VBD cord-015306-us58wwmp 3986 3 outside outside JJ cord-015306-us58wwmp 3986 4 target target NN cord-015306-us58wwmp 3986 5 in in IN cord-015306-us58wwmp 3986 6 56 56 CD cord-015306-us58wwmp 3986 7 % % NN cord-015306-us58wwmp 3986 8 of of IN cord-015306-us58wwmp 3986 9 HD hd NN cord-015306-us58wwmp 3986 10 , , , cord-015306-us58wwmp 3986 11 58 58 CD cord-015306-us58wwmp 3986 12 % % NN cord-015306-us58wwmp 3986 13 of of IN cord-015306-us58wwmp 3986 14 PD PD NNP cord-015306-us58wwmp 3986 15 and and CC cord-015306-us58wwmp 3986 16 14 14 CD cord-015306-us58wwmp 3986 17 % % NN cord-015306-us58wwmp 3986 18 of of IN cord-015306-us58wwmp 3986 19 transplanted transplanted JJ cord-015306-us58wwmp 3986 20 patients patient NNS cord-015306-us58wwmp 3986 21 . . . cord-015306-us58wwmp 3987 1 In in IN cord-015306-us58wwmp 3987 2 dialysis dialysis NN cord-015306-us58wwmp 3987 3 patients patient NNS cord-015306-us58wwmp 3987 4 , , , cord-015306-us58wwmp 3987 5 calcium calcium NN cord-015306-us58wwmp 3987 6 and and CC cord-015306-us58wwmp 3987 7 PTH PTH NNP cord-015306-us58wwmp 3987 8 were be VBD cord-015306-us58wwmp 3987 9 inversely inversely RB cord-015306-us58wwmp 3987 10 associated associate VBN cord-015306-us58wwmp 3987 11 with with IN cord-015306-us58wwmp 3987 12 age age NN cord-015306-us58wwmp 3987 13 ; ; : cord-015306-us58wwmp 3987 14 53 53 CD cord-015306-us58wwmp 3987 15 % % NN cord-015306-us58wwmp 3987 16 of of IN cord-015306-us58wwmp 3987 17 adolescents adolescent NNS cord-015306-us58wwmp 3987 18 were be VBD cord-015306-us58wwmp 3987 19 hyperphosphataemic hyperphosphataemic NN cord-015306-us58wwmp 3987 20 resulting result VBG cord-015306-us58wwmp 3987 21 in in IN cord-015306-us58wwmp 3987 22 a a DT cord-015306-us58wwmp 3987 23 significantly significantly RB cord-015306-us58wwmp 3987 24 higher high JJR cord-015306-us58wwmp 3987 25 risk risk NN cord-015306-us58wwmp 3987 26 compared compare VBN cord-015306-us58wwmp 3987 27 to to IN cord-015306-us58wwmp 3987 28 3 3 CD cord-015306-us58wwmp 3987 29 - - SYM cord-015306-us58wwmp 3987 30 5 5 CD cord-015306-us58wwmp 3987 31 year year NN cord-015306-us58wwmp 3987 32 olds old NNS cord-015306-us58wwmp 3987 33 ( ( -LRB- cord-015306-us58wwmp 3987 34 OR:1.77 OR:1.77 NNP cord-015306-us58wwmp 3987 35 , , , cord-015306-us58wwmp 3987 36 95%CI:1.43 95%ci:1.43 CD cord-015306-us58wwmp 3987 37 - - HYPH cord-015306-us58wwmp 3987 38 2.19 2.19 CD cord-015306-us58wwmp 3987 39 ) ) -RRB- cord-015306-us58wwmp 3987 40 . . . cord-015306-us58wwmp 3988 1 Patients patient NNS cord-015306-us58wwmp 3988 2 transplanted transplant VBD cord-015306-us58wwmp 3988 3 pre pre NNP cord-015306-us58wwmp 3988 4 - - NN cord-015306-us58wwmp 3988 5 emptively emptively NNP cord-015306-us58wwmp 3988 6 had have VBD cord-015306-us58wwmp 3988 7 a a DT cord-015306-us58wwmp 3988 8 lower low JJR cord-015306-us58wwmp 3988 9 risk risk NN cord-015306-us58wwmp 3988 10 of of IN cord-015306-us58wwmp 3988 11 hypocalcaemia hypocalcaemia NNP cord-015306-us58wwmp 3989 1 compared compare VBN cord-015306-us58wwmp 3989 2 FGF23 fgf23 NN cord-015306-us58wwmp 3990 1 Is be VBZ cord-015306-us58wwmp 3990 2 Modulated modulate VBN cord-015306-us58wwmp 3990 3 By by IN cord-015306-us58wwmp 3990 4 Calcium calcium NN cord-015306-us58wwmp 3991 1 In in IN cord-015306-us58wwmp 3991 2 Children child NNS cord-015306-us58wwmp 3992 1 Under under IN cord-015306-us58wwmp 3992 2 Chronic Chronic NNP cord-015306-us58wwmp 3992 3 Peritoneal Peritoneal NNP cord-015306-us58wwmp 3992 4 Dialysis Dialysis NNP cord-015306-us58wwmp 3992 5 Azocar Azocar NNP cord-015306-us58wwmp 3992 6 1 1 CD cord-015306-us58wwmp 3992 7 , , , cord-015306-us58wwmp 3992 8 Maria Maria NNP cord-015306-us58wwmp 3992 9 L. L. NNP cord-015306-us58wwmp 3992 10 Ceballos Ceballos NNP cord-015306-us58wwmp 3992 11 1 1 CD cord-015306-us58wwmp 3992 12 , , , cord-015306-us58wwmp 3992 13 Angelica Angelica NNP cord-015306-us58wwmp 3992 14 M. M. NNP cord-015306-us58wwmp 3992 15 Rojo Rojo NNP cord-015306-us58wwmp 3992 16 1 1 CD cord-015306-us58wwmp 3993 1 Luis Luis NNP cord-015306-us58wwmp 3993 2 Calvo Calvo NNP cord-015306-us58wwmp 3993 3 Mackenna Mackenna NNP cord-015306-us58wwmp 3993 4 Children Children NNP cord-015306-us58wwmp 3993 5 's 's POS cord-015306-us58wwmp 3993 6 Hospital Hospital NNP cord-015306-us58wwmp 3993 7 Human Human NNP cord-015306-us58wwmp 3993 8 intact intact JJ cord-015306-us58wwmp 3993 9 FGF-23 fgf-23 CD cord-015306-us58wwmp 3993 10 levels level NNS cord-015306-us58wwmp 3993 11 ( ( -LRB- cord-015306-us58wwmp 3993 12 pg pg NNP cord-015306-us58wwmp 3993 13 / / SYM cord-015306-us58wwmp 3993 14 ml ml XX cord-015306-us58wwmp 3993 15 , , , cord-015306-us58wwmp 3993 16 Immutopics Immutopics NNP cord-015306-us58wwmp 3993 17 ) ) -RRB- cord-015306-us58wwmp 3993 18 were be VBD cord-015306-us58wwmp 3993 19 determined determine VBN cord-015306-us58wwmp 3993 20 through through IN cord-015306-us58wwmp 3993 21 a a DT cord-015306-us58wwmp 3993 22 2-site 2-site CD cord-015306-us58wwmp 3993 23 ELISA ELISA NNP cord-015306-us58wwmp 3993 24 kit kit NN cord-015306-us58wwmp 3993 25 . . . cord-015306-us58wwmp 3994 1 Klotho Klotho NNP cord-015306-us58wwmp 3994 2 levels level NNS cord-015306-us58wwmp 3994 3 were be VBD cord-015306-us58wwmp 3994 4 determined determine VBN cord-015306-us58wwmp 3994 5 by by IN cord-015306-us58wwmp 3994 6 a a DT cord-015306-us58wwmp 3994 7 solid solid JJ cord-015306-us58wwmp 3994 8 phase phase NN cord-015306-us58wwmp 3994 9 sandwich sandwich NN cord-015306-us58wwmp 3994 10 ELISA ELISA NNP cord-015306-us58wwmp 3994 11 kit kit NNP cord-015306-us58wwmp 3994 12 ( ( -LRB- cord-015306-us58wwmp 3994 13 pg pg NNP cord-015306-us58wwmp 3994 14 / / SYM cord-015306-us58wwmp 3994 15 ml ml NNP cord-015306-us58wwmp 3994 16 ) ) -RRB- cord-015306-us58wwmp 3994 17 . . . cord-015306-us58wwmp 3995 1 Descriptive descriptive JJ cord-015306-us58wwmp 3995 2 statistics statistic NNS cord-015306-us58wwmp 3995 3 , , , cord-015306-us58wwmp 3995 4 univariate univariate JJ cord-015306-us58wwmp 3995 5 and and CC cord-015306-us58wwmp 3995 6 multivariate multivariate JJ cord-015306-us58wwmp 3995 7 analysis analysis NN cord-015306-us58wwmp 3995 8 were be VBD cord-015306-us58wwmp 3995 9 performed perform VBN cord-015306-us58wwmp 3995 10 Methods method NNS cord-015306-us58wwmp 3995 11 : : : cord-015306-us58wwmp 3995 12 We -PRON- PRP cord-015306-us58wwmp 3995 13 measured measure VBD cord-015306-us58wwmp 3995 14 serum serum NN cord-015306-us58wwmp 3995 15 calcium calcium NN cord-015306-us58wwmp 3995 16 , , , cord-015306-us58wwmp 3995 17 phosphorus phosphorus NN cord-015306-us58wwmp 3995 18 , , , cord-015306-us58wwmp 3995 19 intact intact JJ cord-015306-us58wwmp 3995 20 parathyroid parathyroid JJ cord-015306-us58wwmp 3995 21 hormone hormone NN cord-015306-us58wwmp 3995 22 , , , cord-015306-us58wwmp 3995 23 alkaline alkaline JJ cord-015306-us58wwmp 3995 24 phosphatase phosphatase NN cord-015306-us58wwmp 3995 25 ( ( -LRB- cord-015306-us58wwmp 3995 26 ALP ALP NNP cord-015306-us58wwmp 3995 27 ) ) -RRB- cord-015306-us58wwmp 3995 28 , , , cord-015306-us58wwmp 3995 29 25-hydroxy 25-hydroxy CD cord-015306-us58wwmp 3995 30 vitamin vitamin NN cord-015306-us58wwmp 3995 31 D3 D3 NNP cord-015306-us58wwmp 3995 32 ( ( -LRB- cord-015306-us58wwmp 3995 33 25D3 25d3 CD cord-015306-us58wwmp 3995 34 ) ) -RRB- cord-015306-us58wwmp 3995 35 , , , cord-015306-us58wwmp 3995 36 1 1 CD cord-015306-us58wwmp 3995 37 , , , cord-015306-us58wwmp 3995 38 25-hydroxy 25-hydroxy CD cord-015306-us58wwmp 3995 39 vitamin vitamin NN cord-015306-us58wwmp 3995 40 D3 D3 NNP cord-015306-us58wwmp 3995 41 ( ( -LRB- cord-015306-us58wwmp 3995 42 1,25D3 1,25d3 CD cord-015306-us58wwmp 3995 43 ) ) -RRB- cord-015306-us58wwmp 3995 44 , , , cord-015306-us58wwmp 3995 45 and and CC cord-015306-us58wwmp 3995 46 FGF-23 FGF-23 NNPS cord-015306-us58wwmp 3995 47 from from IN cord-015306-us58wwmp 3995 48 233 233 CD cord-015306-us58wwmp 3995 49 children child NNS cord-015306-us58wwmp 3995 50 ( ( -LRB- cord-015306-us58wwmp 3995 51 Male male JJ cord-015306-us58wwmp 3995 52 : : : cord-015306-us58wwmp 3995 53 female female JJ cord-015306-us58wwmp 3995 54 = = NFP cord-015306-us58wwmp 3996 1 157:76 157:76 CD cord-015306-us58wwmp 3997 1 , , , cord-015306-us58wwmp 3997 2 Mean mean JJ cord-015306-us58wwmp 3997 3 age age NN cord-015306-us58wwmp 3997 4 10.2 10.2 CD cord-015306-us58wwmp 3997 5 years year NNS cord-015306-us58wwmp 3997 6 ) ) -RRB- cord-015306-us58wwmp 3997 7 with with IN cord-015306-us58wwmp 3997 8 CKD CKD NNP cord-015306-us58wwmp 3997 9 stage stage NN cord-015306-us58wwmp 3997 10 I I NNP cord-015306-us58wwmp 3997 11 - - HYPH cord-015306-us58wwmp 3997 12 V v NN cord-015306-us58wwmp 3997 13 predialysis predialysis NN cord-015306-us58wwmp 3997 14 in in IN cord-015306-us58wwmp 3997 15 Korea Korea NNP cord-015306-us58wwmp 3997 16 with with IN cord-015306-us58wwmp 3997 17 0.5 0.5 CD cord-015306-us58wwmp 3997 18 - - SYM cord-015306-us58wwmp 3997 19 1 1 CD cord-015306-us58wwmp 3997 20 year year NN cord-015306-us58wwmp 3997 21 intervals interval NNS cord-015306-us58wwmp 3997 22 since since IN cord-015306-us58wwmp 3997 23 2011 2011 CD cord-015306-us58wwmp 3997 24 . . . cord-015306-us58wwmp 3998 1 Results result NNS cord-015306-us58wwmp 3998 2 : : : cord-015306-us58wwmp 3999 1 Hypocalcemia Hypocalcemia NNP cord-015306-us58wwmp 3999 2 was be VBD cord-015306-us58wwmp 3999 3 observed observe VBN cord-015306-us58wwmp 3999 4 in in IN cord-015306-us58wwmp 3999 5 23.8 23.8 CD cord-015306-us58wwmp 3999 6 % % NN cord-015306-us58wwmp 3999 7 , , , cord-015306-us58wwmp 3999 8 32.4 32.4 CD cord-015306-us58wwmp 3999 9 % % NN cord-015306-us58wwmp 3999 10 , , , cord-015306-us58wwmp 3999 11 21.8 21.8 CD cord-015306-us58wwmp 3999 12 % % NN cord-015306-us58wwmp 3999 13 , , , cord-015306-us58wwmp 3999 14 22.4 22.4 CD cord-015306-us58wwmp 3999 15 % % NN cord-015306-us58wwmp 3999 16 and and CC cord-015306-us58wwmp 3999 17 31.8 31.8 CD cord-015306-us58wwmp 3999 18 % % NN cord-015306-us58wwmp 3999 19 of of IN cord-015306-us58wwmp 3999 20 patients patient NNS cord-015306-us58wwmp 3999 21 with with IN cord-015306-us58wwmp 3999 22 CDK CDK NNP cord-015306-us58wwmp 3999 23 I I NNP cord-015306-us58wwmp 3999 24 to to IN cord-015306-us58wwmp 3999 25 V v NN cord-015306-us58wwmp 4000 1 ( ( -LRB- cord-015306-us58wwmp 4000 2 The the DT cord-015306-us58wwmp 4000 3 rest rest NN cord-015306-us58wwmp 4000 4 is be VBZ cord-015306-us58wwmp 4000 5 the the DT cord-015306-us58wwmp 4000 6 same same JJ cord-015306-us58wwmp 4000 7 as as IN cord-015306-us58wwmp 4000 8 above above RB cord-015306-us58wwmp 4000 9 ) ) -RRB- cord-015306-us58wwmp 4000 10 3 3 CD cord-015306-us58wwmp 4000 11 % % NN cord-015306-us58wwmp 4000 12 , , , cord-015306-us58wwmp 4000 13 8.3 8.3 CD cord-015306-us58wwmp 4000 14 % % NN cord-015306-us58wwmp 4000 15 , , , cord-015306-us58wwmp 4000 16 47.1 47.1 CD cord-015306-us58wwmp 4000 17 % % NN cord-015306-us58wwmp 4000 18 , , , cord-015306-us58wwmp 4000 19 68.1 68.1 CD cord-015306-us58wwmp 4000 20 % % NN cord-015306-us58wwmp 4000 21 and and CC cord-015306-us58wwmp 4000 22 40.9 40.9 CD cord-015306-us58wwmp 4000 23 % % NN cord-015306-us58wwmp 4000 24 . . . cord-015306-us58wwmp 4001 1 25D3 25d3 CD cord-015306-us58wwmp 4001 2 level level NN cord-015306-us58wwmp 4001 3 was be VBD cord-015306-us58wwmp 4001 4 below below IN cord-015306-us58wwmp 4001 5 FGF-23 FGF-23 NNP cord-015306-us58wwmp 4002 1 ( ( -LRB- cord-015306-us58wwmp 4002 2 RU RU NNP cord-015306-us58wwmp 4002 3 / / SYM cord-015306-us58wwmp 4002 4 mL mL NNP cord-015306-us58wwmp 4002 5 ) ) -RRB- cord-015306-us58wwmp 4002 6 was be VBD cord-015306-us58wwmp 4002 7 38.0 38.0 CD cord-015306-us58wwmp 4002 8 , , , cord-015306-us58wwmp 4002 9 44.9 44.9 CD cord-015306-us58wwmp 4002 10 , , , cord-015306-us58wwmp 4002 11 54.4 54.4 CD cord-015306-us58wwmp 4002 12 , , , cord-015306-us58wwmp 4002 13 67.3 67.3 CD cord-015306-us58wwmp 4002 14 and and CC cord-015306-us58wwmp 4002 15 119.6 119.6 CD cord-015306-us58wwmp 4002 16 . . . cord-015306-us58wwmp 4003 1 Serum serum NN cord-015306-us58wwmp 4003 2 P p NN cord-015306-us58wwmp 4003 3 had have VBD cord-015306-us58wwmp 4003 4 positive positive JJ cord-015306-us58wwmp 4003 5 correlation correlation NN cord-015306-us58wwmp 4003 6 with with IN cord-015306-us58wwmp 4003 7 ALP ALP NNP cord-015306-us58wwmp 4003 8 ( ( -LRB- cord-015306-us58wwmp 4003 9 P p NN cord-015306-us58wwmp 4003 10 < < XX cord-015306-us58wwmp 4003 11 0.0001 0.0001 CD cord-015306-us58wwmp 4003 12 ) ) -RRB- cord-015306-us58wwmp 4003 13 , , , cord-015306-us58wwmp 4003 14 iPTH iPTH NNP cord-015306-us58wwmp 4003 15 ( ( -LRB- cord-015306-us58wwmp 4003 16 P p NN cord-015306-us58wwmp 4003 17 = = SYM cord-015306-us58wwmp 4003 18 0.0489 0.0489 CD cord-015306-us58wwmp 4003 19 ) ) -RRB- cord-015306-us58wwmp 4003 20 and and CC cord-015306-us58wwmp 4003 21 FGF-23 fgf-23 CD cord-015306-us58wwmp 4003 22 levels level NNS cord-015306-us58wwmp 4003 23 ( ( -LRB- cord-015306-us58wwmp 4003 24 P p NN cord-015306-us58wwmp 4003 25 < < XX cord-015306-us58wwmp 4003 26 0.0001 0.0001 CD cord-015306-us58wwmp 4003 27 ) ) -RRB- cord-015306-us58wwmp 4003 28 and and CC cord-015306-us58wwmp 4003 29 was be VBD cord-015306-us58wwmp 4003 30 inversely inversely RB cord-015306-us58wwmp 4003 31 correlated correlate VBN cord-015306-us58wwmp 4003 32 with with IN cord-015306-us58wwmp 4003 33 urine urine NN cord-015306-us58wwmp 4003 34 phosphorus phosphorus NN cord-015306-us58wwmp 4003 35 Conclusion conclusion NN cord-015306-us58wwmp 4003 36 : : : cord-015306-us58wwmp 4003 37 The the DT cord-015306-us58wwmp 4003 38 prevalence prevalence NN cord-015306-us58wwmp 4003 39 of of IN cord-015306-us58wwmp 4003 40 hypocalcemia hypocalcemia NN cord-015306-us58wwmp 4003 41 , , , cord-015306-us58wwmp 4003 42 hyperphosphatemia hyperphosphatemia NN cord-015306-us58wwmp 4003 43 and and CC cord-015306-us58wwmp 4003 44 hyperparathyroidism hyperparathyroidism NN cord-015306-us58wwmp 4003 45 increased increase VBD cord-015306-us58wwmp 4003 46 as as IN cord-015306-us58wwmp 4003 47 CKD CKD NNP cord-015306-us58wwmp 4003 48 progressed progress VBD cord-015306-us58wwmp 4003 49 . . . cord-015306-us58wwmp 4004 1 Serum serum NN cord-015306-us58wwmp 4004 2 iPTH ipth NN cord-015306-us58wwmp 4004 3 and and CC cord-015306-us58wwmp 4004 4 FGF-23 FGF-23 NNPS cord-015306-us58wwmp 4004 5 increased increase VBD cord-015306-us58wwmp 4004 6 and and CC cord-015306-us58wwmp 4004 7 1,25D3 1,25d3 CD cord-015306-us58wwmp 4004 8 level level NN cord-015306-us58wwmp 4004 9 decreased decrease VBD cord-015306-us58wwmp 4004 10 in in IN cord-015306-us58wwmp 4004 11 proportion proportion NN cord-015306-us58wwmp 4004 12 to to IN cord-015306-us58wwmp 4004 13 the the DT cord-015306-us58wwmp 4004 14 progression progression NN cord-015306-us58wwmp 4004 15 of of IN cord-015306-us58wwmp 4004 16 CKD CKD NNP cord-015306-us58wwmp 4004 17 Malaysia Malaysia NNP cord-015306-us58wwmp 4004 18 6 6 CD cord-015306-us58wwmp 4004 19 National National NNP cord-015306-us58wwmp 4004 20 Transplant Transplant NNP cord-015306-us58wwmp 4004 21 Resource Resource NNP cord-015306-us58wwmp 4004 22 Centre Centre NNP cord-015306-us58wwmp 4004 23 , , , cord-015306-us58wwmp 4004 24 National National NNP cord-015306-us58wwmp 4004 25 Transplant Transplant NNP cord-015306-us58wwmp 4004 26 Resource Resource NNP cord-015306-us58wwmp 4004 27 Centre Centre NNP cord-015306-us58wwmp 4004 28 , , , cord-015306-us58wwmp 4004 29 Kuala Kuala NNP cord-015306-us58wwmp 4004 30 Lumpur Lumpur NNP cord-015306-us58wwmp 4004 31 , , , cord-015306-us58wwmp 4005 1 Malaysia Malaysia NNP cord-015306-us58wwmp 4005 2 Objective Objective NNP cord-015306-us58wwmp 4005 3 : : : cord-015306-us58wwmp 4006 1 To to TO cord-015306-us58wwmp 4006 2 analyse analyse VB cord-015306-us58wwmp 4006 3 the the DT cord-015306-us58wwmp 4006 4 cost cost NN cord-015306-us58wwmp 4006 5 - - HYPH cord-015306-us58wwmp 4006 6 effectiveness effectiveness NN cord-015306-us58wwmp 4006 7 of of IN cord-015306-us58wwmp 4006 8 paediatric paediatric JJ cord-015306-us58wwmp 4006 9 and and CC cord-015306-us58wwmp 4006 10 adult adult NN cord-015306-us58wwmp 4006 11 living living NN cord-015306-us58wwmp 4006 12 related related JJ cord-015306-us58wwmp 4006 13 renal renal JJ cord-015306-us58wwmp 4006 14 transplantation transplantation NN cord-015306-us58wwmp 4006 15 ( ( -LRB- cord-015306-us58wwmp 4006 16 LRT LRT NNP cord-015306-us58wwmp 4006 17 ) ) -RRB- cord-015306-us58wwmp 4006 18 and and CC cord-015306-us58wwmp 4006 19 deceased deceased JJ cord-015306-us58wwmp 4006 20 donor donor NN cord-015306-us58wwmp 4006 21 renal renal JJ cord-015306-us58wwmp 4006 22 transplantation transplantation NN cord-015306-us58wwmp 4006 23 ( ( -LRB- cord-015306-us58wwmp 4006 24 DRT DRT NNP cord-015306-us58wwmp 4006 25 ) ) -RRB- cord-015306-us58wwmp 4007 1 The the DT cord-015306-us58wwmp 4007 2 time time NN cord-015306-us58wwmp 4007 3 horizon horizon NN cord-015306-us58wwmp 4007 4 was be VBD cord-015306-us58wwmp 4007 5 the the DT cord-015306-us58wwmp 4007 6 lifetime lifetime NN cord-015306-us58wwmp 4007 7 of of IN cord-015306-us58wwmp 4007 8 transplant transplant NN cord-015306-us58wwmp 4007 9 recipient recipient NN cord-015306-us58wwmp 4007 10 from from IN cord-015306-us58wwmp 4007 11 transplant transplant NN cord-015306-us58wwmp 4007 12 to to IN cord-015306-us58wwmp 4007 13 death death NN cord-015306-us58wwmp 4007 14 . . . cord-015306-us58wwmp 4008 1 Data datum NNS cord-015306-us58wwmp 4008 2 for for IN cord-015306-us58wwmp 4008 3 survival survival NN cord-015306-us58wwmp 4008 4 analysis analysis NN cord-015306-us58wwmp 4008 5 was be VBD cord-015306-us58wwmp 4008 6 obtained obtain VBN cord-015306-us58wwmp 4008 7 from from IN cord-015306-us58wwmp 4008 8 National National NNP cord-015306-us58wwmp 4008 9 Renal Renal NNP cord-015306-us58wwmp 4008 10 Registry Registry NNP cord-015306-us58wwmp 4008 11 . . . cord-015306-us58wwmp 4009 1 Statistical statistical JJ cord-015306-us58wwmp 4009 2 analysis analysis NN cord-015306-us58wwmp 4009 3 was be VBD cord-015306-us58wwmp 4009 4 performed perform VBN cord-015306-us58wwmp 4009 5 using use VBG cord-015306-us58wwmp 4009 6 STATA STATA NNP cord-015306-us58wwmp 4009 7 SE SE NNP cord-015306-us58wwmp 4009 8 version version NN cord-015306-us58wwmp 4009 9 11.2 11.2 CD cord-015306-us58wwmp 4009 10 . . . cord-015306-us58wwmp 4010 1 The the DT cord-015306-us58wwmp 4010 2 costs cost NNS cord-015306-us58wwmp 4010 3 was be VBD cord-015306-us58wwmp 4010 4 discounted discount VBN cord-015306-us58wwmp 4010 5 at at IN cord-015306-us58wwmp 4010 6 3 3 CD cord-015306-us58wwmp 4010 7 % % NN cord-015306-us58wwmp 4010 8 p.a p.a NN cord-015306-us58wwmp 4010 9 . . . cord-015306-us58wwmp 4010 10 Results result NNS cord-015306-us58wwmp 4010 11 : : : cord-015306-us58wwmp 4010 12 We -PRON- PRP cord-015306-us58wwmp 4010 13 reviewed review VBD cord-015306-us58wwmp 4010 14 206 206 CD cord-015306-us58wwmp 4010 15 medical medical JJ cord-015306-us58wwmp 4010 16 records record NNS cord-015306-us58wwmp 4010 17 . . . cord-015306-us58wwmp 4011 1 There there EX cord-015306-us58wwmp 4011 2 were be VBD cord-015306-us58wwmp 4011 3 88 88 CD cord-015306-us58wwmp 4011 4 children child NNS cord-015306-us58wwmp 4011 5 ( ( -LRB- cord-015306-us58wwmp 4011 6 39 39 CD cord-015306-us58wwmp 4011 7 LRT LRT NNP cord-015306-us58wwmp 4011 8 , , , cord-015306-us58wwmp 4011 9 49 49 CD cord-015306-us58wwmp 4011 10 DRT DRT NNP cord-015306-us58wwmp 4011 11 ) ) -RRB- cord-015306-us58wwmp 4011 12 and and CC cord-015306-us58wwmp 4011 13 118 118 CD cord-015306-us58wwmp 4011 14 adults adult NNS cord-015306-us58wwmp 4011 15 ( ( -LRB- cord-015306-us58wwmp 4011 16 63 63 CD cord-015306-us58wwmp 4011 17 LRT LRT NNP cord-015306-us58wwmp 4011 18 , , , cord-015306-us58wwmp 4011 19 55 55 CD cord-015306-us58wwmp 4011 20 DRT DRT NNP cord-015306-us58wwmp 4011 21 ) ) -RRB- cord-015306-us58wwmp 4011 22 . . . cord-015306-us58wwmp 4012 1 The the DT cord-015306-us58wwmp 4012 2 paediatric paediatric JJ cord-015306-us58wwmp 4012 3 recipients recipient NNS cord-015306-us58wwmp 4012 4 mean mean VBP cord-015306-us58wwmp 4012 5 age age NN cord-015306-us58wwmp 4012 6 was be VBD cord-015306-us58wwmp 4012 7 12.3 12.3 CD cord-015306-us58wwmp 4012 8 + + CC cord-015306-us58wwmp 4012 9 /-3.4 /-3.4 . cord-015306-us58wwmp 4012 10 ( ( -LRB- cord-015306-us58wwmp 4012 11 LRT LRT NNP cord-015306-us58wwmp 4012 12 ) ) -RRB- cord-015306-us58wwmp 4012 13 and and CC cord-015306-us58wwmp 4012 14 14.0 14.0 CD cord-015306-us58wwmp 4012 15 + + CC cord-015306-us58wwmp 4012 16 /-2.4 /-2.4 CD cord-015306-us58wwmp 4012 17 years year NNS cord-015306-us58wwmp 4012 18 ( ( -LRB- cord-015306-us58wwmp 4012 19 DRT DRT NNP cord-015306-us58wwmp 4012 20 ) ) -RRB- cord-015306-us58wwmp 4012 21 , , , cord-015306-us58wwmp 4012 22 whereas whereas IN cord-015306-us58wwmp 4012 23 the the DT cord-015306-us58wwmp 4012 24 adult adult NN cord-015306-us58wwmp 4012 25 recipients recipient NNS cord-015306-us58wwmp 4012 26 mean mean VBP cord-015306-us58wwmp 4012 27 age age NN cord-015306-us58wwmp 4012 28 was be VBD cord-015306-us58wwmp 4012 29 33.4 33.4 CD cord-015306-us58wwmp 4012 30 + + CC cord-015306-us58wwmp 4012 31 /-10.3 /-10.3 . cord-015306-us58wwmp 4012 32 ( ( -LRB- cord-015306-us58wwmp 4012 33 LRT LRT NNP cord-015306-us58wwmp 4012 34 ) ) -RRB- cord-015306-us58wwmp 4012 35 and and CC cord-015306-us58wwmp 4012 36 41.8 41.8 CD cord-015306-us58wwmp 4012 37 ±8.9 ±8.9 JJ cord-015306-us58wwmp 4012 38 years year NNS cord-015306-us58wwmp 4012 39 ( ( -LRB- cord-015306-us58wwmp 4012 40 DRT DRT NNP cord-015306-us58wwmp 4012 41 ) ) -RRB- cord-015306-us58wwmp 4012 42 . . . cord-015306-us58wwmp 4013 1 The the DT cord-015306-us58wwmp 4013 2 5 5 CD cord-015306-us58wwmp 4013 3 and and CC cord-015306-us58wwmp 4013 4 10-year 10-year CD cord-015306-us58wwmp 4013 5 patient patient JJ cord-015306-us58wwmp 4013 6 survival survival NN cord-015306-us58wwmp 4013 7 rates rate NNS cord-015306-us58wwmp 4013 8 for for IN cord-015306-us58wwmp 4013 9 both both CC cord-015306-us58wwmp 4013 10 paediatric paediatric JJ cord-015306-us58wwmp 4013 11 LRT LRT NNP cord-015306-us58wwmp 4013 12 and and CC cord-015306-us58wwmp 4013 13 DRT DRT NNP cord-015306-us58wwmp 4013 14 were be VBD cord-015306-us58wwmp 4013 15 95 95 CD cord-015306-us58wwmp 4013 16 % % NN cord-015306-us58wwmp 4013 17 and and CC cord-015306-us58wwmp 4013 18 85 85 CD cord-015306-us58wwmp 4013 19 % % NN cord-015306-us58wwmp 4013 20 respectively respectively RB cord-015306-us58wwmp 4013 21 . . . cord-015306-us58wwmp 4014 1 The the DT cord-015306-us58wwmp 4014 2 5 5 CD cord-015306-us58wwmp 4014 3 and and CC cord-015306-us58wwmp 4014 4 10-year 10-year CD cord-015306-us58wwmp 4014 5 patient patient JJ cord-015306-us58wwmp 4014 6 survival survival NN cord-015306-us58wwmp 4014 7 rate rate NN cord-015306-us58wwmp 4014 8 for for IN cord-015306-us58wwmp 4014 9 adult adult NN cord-015306-us58wwmp 4014 10 LRT LRT NNP cord-015306-us58wwmp 4014 11 was be VBD cord-015306-us58wwmp 4014 12 92.5 92.5 CD cord-015306-us58wwmp 4014 13 % % NN cord-015306-us58wwmp 4014 14 and and CC cord-015306-us58wwmp 4014 15 90 90 CD cord-015306-us58wwmp 4014 16 % % NN cord-015306-us58wwmp 4014 17 respectively respectively RB cord-015306-us58wwmp 4014 18 , , , cord-015306-us58wwmp 4014 19 whereas whereas IN cord-015306-us58wwmp 4014 20 adult adult NN cord-015306-us58wwmp 4014 21 DRT DRT NNP cord-015306-us58wwmp 4014 22 was be VBD cord-015306-us58wwmp 4014 23 77.5 77.5 CD cord-015306-us58wwmp 4014 24 % % NN cord-015306-us58wwmp 4014 25 and and CC cord-015306-us58wwmp 4014 26 70 70 CD cord-015306-us58wwmp 4014 27 % % NN cord-015306-us58wwmp 4014 28 respectively respectively RB cord-015306-us58wwmp 4014 29 . . . cord-015306-us58wwmp 4015 1 Mean mean JJ cord-015306-us58wwmp 4015 2 cost cost NN cord-015306-us58wwmp 4015 3 per per IN cord-015306-us58wwmp 4015 4 paediatric paediatric JJ cord-015306-us58wwmp 4015 5 transplant transplant NN cord-015306-us58wwmp 4015 6 at at IN cord-015306-us58wwmp 4015 7 first first JJ cord-015306-us58wwmp 4015 8 year year NN cord-015306-us58wwmp 4015 9 was be VBD cord-015306-us58wwmp 4015 10 RM RM NNP cord-015306-us58wwmp 4015 11 81,000 81,000 CD cord-015306-us58wwmp 4015 12 ( ( -LRB- cord-015306-us58wwmp 4015 13 LRT LRT NNP cord-015306-us58wwmp 4015 14 ) ) -RRB- cord-015306-us58wwmp 4015 15 and and CC cord-015306-us58wwmp 4015 16 90,000 90,000 CD cord-015306-us58wwmp 4015 17 ( ( -LRB- cord-015306-us58wwmp 4015 18 CRT CRT NNP cord-015306-us58wwmp 4015 19 ) ) -RRB- cord-015306-us58wwmp 4015 20 , , , cord-015306-us58wwmp 4015 21 from from IN cord-015306-us58wwmp 4015 22 second second JJ cord-015306-us58wwmp 4015 23 year year NN cord-015306-us58wwmp 4015 24 onwards onwards RB cord-015306-us58wwmp 4015 25 was be VBD cord-015306-us58wwmp 4015 26 at at IN cord-015306-us58wwmp 4015 27 20,000 20,000 CD cord-015306-us58wwmp 4015 28 per per IN cord-015306-us58wwmp 4015 29 year year NN cord-015306-us58wwmp 4015 30 ( ( -LRB- cord-015306-us58wwmp 4015 31 LRT LRT NNP cord-015306-us58wwmp 4015 32 ) ) -RRB- cord-015306-us58wwmp 4015 33 and and CC cord-015306-us58wwmp 4015 34 37,000 37,000 CD cord-015306-us58wwmp 4015 35 per per IN cord-015306-us58wwmp 4015 36 year year NN cord-015306-us58wwmp 4015 37 ( ( -LRB- cord-015306-us58wwmp 4015 38 DRT DRT NNP cord-015306-us58wwmp 4015 39 ) ) -RRB- cord-015306-us58wwmp 4015 40 . . . cord-015306-us58wwmp 4016 1 The the DT cord-015306-us58wwmp 4016 2 total total JJ cord-015306-us58wwmp 4016 3 lifetime lifetime NN cord-015306-us58wwmp 4016 4 cost cost NN cord-015306-us58wwmp 4016 5 was be VBD cord-015306-us58wwmp 4016 6 RM RM NNP cord-015306-us58wwmp 4016 7 650,000 650,000 CD cord-015306-us58wwmp 4017 1 ( ( -LRB- cord-015306-us58wwmp 4017 2 LRT LRT NNP cord-015306-us58wwmp 4017 3 ) ) -RRB- cord-015306-us58wwmp 4017 4 and and CC cord-015306-us58wwmp 4017 5 630,000 630,000 CD cord-015306-us58wwmp 4017 6 ( ( -LRB- cord-015306-us58wwmp 4017 7 DRT DRT NNP cord-015306-us58wwmp 4017 8 ) ) -RRB- cord-015306-us58wwmp 4018 1 Their -PRON- PRP$ cord-015306-us58wwmp 4018 2 serum serum NN cord-015306-us58wwmp 4018 3 creatinine creatinine NN cord-015306-us58wwmp 4018 4 , , , cord-015306-us58wwmp 4018 5 eGFR egfr NN cord-015306-us58wwmp 4018 6 , , , cord-015306-us58wwmp 4018 7 cholesterol cholesterol NN cord-015306-us58wwmp 4018 8 , , , cord-015306-us58wwmp 4018 9 LDL ldl NN cord-015306-us58wwmp 4018 10 , , , cord-015306-us58wwmp 4018 11 proteinuria proteinuria NN cord-015306-us58wwmp 4018 12 , , , cord-015306-us58wwmp 4018 13 full full JJ cord-015306-us58wwmp 4018 14 blood blood NN cord-015306-us58wwmp 4018 15 counts count NNS cord-015306-us58wwmp 4018 16 and and CC cord-015306-us58wwmp 4018 17 liver liver NN cord-015306-us58wwmp 4018 18 function function NN cord-015306-us58wwmp 4018 19 were be VBD cord-015306-us58wwmp 4018 20 profiled profile VBN cord-015306-us58wwmp 4018 21 to to TO cord-015306-us58wwmp 4018 22 compare compare VB cord-015306-us58wwmp 4018 23 the the DT cord-015306-us58wwmp 4018 24 pre-/post pre-/post NN cord-015306-us58wwmp 4018 25 - - HYPH cord-015306-us58wwmp 4018 26 conversion conversion NN cord-015306-us58wwmp 4018 27 changes change NNS cord-015306-us58wwmp 4018 28 . . . cord-015306-us58wwmp 4019 1 Common common JJ cord-015306-us58wwmp 4019 2 adverse adverse JJ cord-015306-us58wwmp 4019 3 effects effect NNS cord-015306-us58wwmp 4019 4 , , , cord-015306-us58wwmp 4019 5 acute acute JJ cord-015306-us58wwmp 4019 6 rejection rejection NN cord-015306-us58wwmp 4019 7 , , , cord-015306-us58wwmp 4019 8 opportunistic opportunistic JJ cord-015306-us58wwmp 4019 9 infection infection NN cord-015306-us58wwmp 4019 10 and and CC cord-015306-us58wwmp 4019 11 need need NN cord-015306-us58wwmp 4019 12 of of IN cord-015306-us58wwmp 4019 13 treatment treatment NN cord-015306-us58wwmp 4019 14 for for IN cord-015306-us58wwmp 4019 15 hypercholesterolaemia hypercholesterolaemia NN cord-015306-us58wwmp 4019 16 and and CC cord-015306-us58wwmp 4019 17 proteinuria proteinuria NN cord-015306-us58wwmp 4019 18 were be VBD cord-015306-us58wwmp 4019 19 investigated investigate VBN cord-015306-us58wwmp 4019 20 . . . cord-015306-us58wwmp 4020 1 Results result NNS cord-015306-us58wwmp 4020 2 : : : cord-015306-us58wwmp 4021 1 We -PRON- PRP cord-015306-us58wwmp 4021 2 have have VBP cord-015306-us58wwmp 4021 3 15 15 CD cord-015306-us58wwmp 4021 4 eligible eligible JJ cord-015306-us58wwmp 4021 5 patients patient NNS cord-015306-us58wwmp 4021 6 with with IN cord-015306-us58wwmp 4021 7 M M NNP cord-015306-us58wwmp 4021 8 : : : cord-015306-us58wwmp 4022 1 F F NNP cord-015306-us58wwmp 4022 2 = = SYM cord-015306-us58wwmp 4022 3 7 7 CD cord-015306-us58wwmp 4022 4 : : SYM cord-015306-us58wwmp 4022 5 8 8 CD cord-015306-us58wwmp 4022 6 . . . cord-015306-us58wwmp 4023 1 The the DT cord-015306-us58wwmp 4023 2 mean mean JJ cord-015306-us58wwmp 4023 3 age age NN cord-015306-us58wwmp 4023 4 at at IN cord-015306-us58wwmp 4023 5 renal renal JJ cord-015306-us58wwmp 4023 6 transplantation transplantation NN cord-015306-us58wwmp 4023 7 was be VBD cord-015306-us58wwmp 4023 8 12 12 CD cord-015306-us58wwmp 4023 9 Sirolimus Sirolimus NNP cord-015306-us58wwmp 4023 10 was be VBD cord-015306-us58wwmp 4023 11 started start VBN cord-015306-us58wwmp 4023 12 at at IN cord-015306-us58wwmp 4023 13 a a DT cord-015306-us58wwmp 4023 14 mean mean JJ cord-015306-us58wwmp 4023 15 age age NN cord-015306-us58wwmp 4023 16 of of IN cord-015306-us58wwmp 4023 17 15.4 15.4 CD cord-015306-us58wwmp 4023 18 + + CC cord-015306-us58wwmp 4023 19 /-5.0 /-5.0 NN cord-015306-us58wwmp 4023 20 , , , cord-015306-us58wwmp 4023 21 at at IN cord-015306-us58wwmp 4023 22 a a DT cord-015306-us58wwmp 4023 23 mean mean JJ cord-015306-us58wwmp 4023 24 time time NN cord-015306-us58wwmp 4023 25 period period NN cord-015306-us58wwmp 4023 26 of of IN cord-015306-us58wwmp 4023 27 + + NN cord-015306-us58wwmp 4023 28 /-2.5 /-2.5 . cord-015306-us58wwmp 4023 29 years year NNS cord-015306-us58wwmp 4023 30 after after IN cord-015306-us58wwmp 4023 31 renal renal JJ cord-015306-us58wwmp 4023 32 transplantation transplantation NN cord-015306-us58wwmp 4023 33 , , , cord-015306-us58wwmp 4023 34 and and CC cord-015306-us58wwmp 4023 35 used use VBN cord-015306-us58wwmp 4023 36 for for IN cord-015306-us58wwmp 4023 37 a a DT cord-015306-us58wwmp 4023 38 mean mean JJ cord-015306-us58wwmp 4023 39 duration duration NN cord-015306-us58wwmp 4023 40 of of IN cord-015306-us58wwmp 4023 41 We -PRON- PRP cord-015306-us58wwmp 4023 42 observed observe VBD cord-015306-us58wwmp 4023 43 new new JJ cord-015306-us58wwmp 4023 44 onset onset NN cord-015306-us58wwmp 4023 45 hyperlipidaemia hyperlipidaemia NN cord-015306-us58wwmp 4023 46 in in IN cord-015306-us58wwmp 4023 47 9 9 CD cord-015306-us58wwmp 4023 48 patients patient NNS cord-015306-us58wwmp 4023 49 ( ( -LRB- cord-015306-us58wwmp 4023 50 60 60 CD cord-015306-us58wwmp 4023 51 % % NN cord-015306-us58wwmp 4023 52 ) ) -RRB- cord-015306-us58wwmp 4023 53 and and CC cord-015306-us58wwmp 4023 54 needed need VBD cord-015306-us58wwmp 4023 55 statin statin NN cord-015306-us58wwmp 4023 56 treatment treatment NN cord-015306-us58wwmp 4023 57 . . . cord-015306-us58wwmp 4024 1 We -PRON- PRP cord-015306-us58wwmp 4024 2 found find VBD cord-015306-us58wwmp 4024 3 significant significant JJ cord-015306-us58wwmp 4024 4 proteinuria proteinuria NN cord-015306-us58wwmp 4024 5 ( ( -LRB- cord-015306-us58wwmp 4024 6 spot spot NN cord-015306-us58wwmp 4024 7 Pr Pr NNP cord-015306-us58wwmp 4024 8 / / SYM cord-015306-us58wwmp 4024 9 Cr cr NN cord-015306-us58wwmp 4024 10 > > XX cord-015306-us58wwmp 4024 11 1.0 1.0 CD cord-015306-us58wwmp 4024 12 mg mg NNP cord-015306-us58wwmp 4024 13 / / SYM cord-015306-us58wwmp 4024 14 mg mg NNP cord-015306-us58wwmp 4024 15 ) ) -RRB- cord-015306-us58wwmp 4024 16 in in IN cord-015306-us58wwmp 4024 17 4 4 CD cord-015306-us58wwmp 4024 18 ( ( -LRB- cord-015306-us58wwmp 4024 19 27 27 CD cord-015306-us58wwmp 4024 20 % % NN cord-015306-us58wwmp 4024 21 ) ) -RRB- cord-015306-us58wwmp 4024 22 patients patient NNS cord-015306-us58wwmp 4024 23 and and CC cord-015306-us58wwmp 4024 24 needed need VBD cord-015306-us58wwmp 4024 25 ACEI ACEI NNP cord-015306-us58wwmp 4024 26 treatment treatment NN cord-015306-us58wwmp 4024 27 . . . cord-015306-us58wwmp 4025 1 There there EX cord-015306-us58wwmp 4025 2 was be VBD cord-015306-us58wwmp 4025 3 no no DT cord-015306-us58wwmp 4025 4 adverse adverse JJ cord-015306-us58wwmp 4025 5 effect effect NN cord-015306-us58wwmp 4025 6 on on IN cord-015306-us58wwmp 4025 7 blood blood NN cord-015306-us58wwmp 4025 8 counts count NNS cord-015306-us58wwmp 4025 9 and and CC cord-015306-us58wwmp 4025 10 liver liver NN cord-015306-us58wwmp 4025 11 function function NN cord-015306-us58wwmp 4025 12 . . . cord-015306-us58wwmp 4026 1 There there EX cord-015306-us58wwmp 4026 2 was be VBD cord-015306-us58wwmp 4026 3 no no DT cord-015306-us58wwmp 4026 4 opportunistic opportunistic JJ cord-015306-us58wwmp 4026 5 infection infection NN cord-015306-us58wwmp 4026 6 observed observe VBN cord-015306-us58wwmp 4026 7 after after IN cord-015306-us58wwmp 4026 8 conversion conversion NN cord-015306-us58wwmp 4026 9 to to IN cord-015306-us58wwmp 4026 10 Sirolimus Sirolimus NNP cord-015306-us58wwmp 4026 11 in in IN cord-015306-us58wwmp 4026 12 the the DT cord-015306-us58wwmp 4026 13 study study NN cord-015306-us58wwmp 4026 14 period period NN cord-015306-us58wwmp 4026 15 . . . cord-015306-us58wwmp 4027 1 There there EX cord-015306-us58wwmp 4027 2 was be VBD cord-015306-us58wwmp 4027 3 one one CD cord-015306-us58wwmp 4027 4 acute acute JJ cord-015306-us58wwmp 4027 5 cellular cellular JJ cord-015306-us58wwmp 4027 6 rejection rejection NN cord-015306-us58wwmp 4027 7 ( ( -LRB- cord-015306-us58wwmp 4027 8 Ia Ia NNP cord-015306-us58wwmp 4027 9 ) ) -RRB- cord-015306-us58wwmp 4027 10 one one CD cord-015306-us58wwmp 4027 11 month month NN cord-015306-us58wwmp 4027 12 after after IN cord-015306-us58wwmp 4027 13 conversion conversion NN cord-015306-us58wwmp 4027 14 to to IN cord-015306-us58wwmp 4027 15 Sirolimus Sirolimus NNP cord-015306-us58wwmp 4027 16 and and CC cord-015306-us58wwmp 4027 17 responded respond VBD cord-015306-us58wwmp 4027 18 to to TO cord-015306-us58wwmp 4027 19 pulse pulse VB cord-015306-us58wwmp 4027 20 methylprednisolone methylprednisolone NNP cord-015306-us58wwmp 4027 21 . . . cord-015306-us58wwmp 4028 1 Conclusion conclusion NN cord-015306-us58wwmp 4028 2 : : : cord-015306-us58wwmp 4028 3 Converting convert VBG cord-015306-us58wwmp 4028 4 from from IN cord-015306-us58wwmp 4028 5 a a DT cord-015306-us58wwmp 4028 6 CNI CNI NNP cord-015306-us58wwmp 4028 7 based base VBN cord-015306-us58wwmp 4028 8 immunosuppressant immunosuppressant JJ cord-015306-us58wwmp 4028 9 protocol protocol NN cord-015306-us58wwmp 4028 10 for for IN cord-015306-us58wwmp 4028 11 Paediatric paediatric JJ cord-015306-us58wwmp 4028 12 renal renal JJ cord-015306-us58wwmp 4028 13 transplantation transplantation NN cord-015306-us58wwmp 4028 14 patients patient NNS cord-015306-us58wwmp 4028 15 to to IN cord-015306-us58wwmp 4028 16 a a DT cord-015306-us58wwmp 4028 17 Sirolimus Sirolimus NNP cord-015306-us58wwmp 4028 18 based base VBN cord-015306-us58wwmp 4028 19 one one CD cord-015306-us58wwmp 4028 20 was be VBD cord-015306-us58wwmp 4028 21 effective effective JJ cord-015306-us58wwmp 4028 22 and and CC cord-015306-us58wwmp 4028 23 the the DT cord-015306-us58wwmp 4028 24 benefit benefit NN cord-015306-us58wwmp 4028 25 was be VBD cord-015306-us58wwmp 4028 26 shown show VBN cord-015306-us58wwmp 4028 27 up up RP cord-015306-us58wwmp 4028 28 to to TO cord-015306-us58wwmp 4028 29 54 54 CD cord-015306-us58wwmp 4028 30 months month NNS cord-015306-us58wwmp 4028 31 post post NN cord-015306-us58wwmp 4028 32 - - NN cord-015306-us58wwmp 4028 33 transplantation transplantation JJ cord-015306-us58wwmp 4029 1 One one CD cord-015306-us58wwmp 4029 2 patient patient NN cord-015306-us58wwmp 4029 3 received receive VBD cord-015306-us58wwmp 4029 4 a a DT cord-015306-us58wwmp 4029 5 desensitisation desensitisation NN cord-015306-us58wwmp 4029 6 regime regime NN cord-015306-us58wwmp 4029 7 with with IN cord-015306-us58wwmp 4029 8 Rituximab Rituximab NNP cord-015306-us58wwmp 4029 9 and and CC cord-015306-us58wwmp 4029 10 plasmaexhange plasmaexhange JJ cord-015306-us58wwmp 4029 11 pre pre NN cord-015306-us58wwmp 4029 12 - - NN cord-015306-us58wwmp 4029 13 transplant transplant NN cord-015306-us58wwmp 4030 1 and and CC cord-015306-us58wwmp 4030 2 IV IV NNP cord-015306-us58wwmp 4030 3 immunoglobulin immunoglobulin NN cord-015306-us58wwmp 4030 4 post post NN cord-015306-us58wwmp 4030 5 - - JJ cord-015306-us58wwmp 4030 6 operatively operatively RB cord-015306-us58wwmp 4030 7 . . . cord-015306-us58wwmp 4031 1 Surgical surgical JJ cord-015306-us58wwmp 4031 2 complications complication NNS cord-015306-us58wwmp 4031 3 occurred occur VBD cord-015306-us58wwmp 4031 4 in in IN cord-015306-us58wwmp 4031 5 7 7 CD cord-015306-us58wwmp 4031 6 patients patient NNS cord-015306-us58wwmp 4031 7 ; ; : cord-015306-us58wwmp 4031 8 2 2 CD cord-015306-us58wwmp 4031 9 lymphocoeles lymphocoele NNS cord-015306-us58wwmp 4031 10 , , , cord-015306-us58wwmp 4031 11 3 3 CD cord-015306-us58wwmp 4031 12 ureteric ureteric JJ cord-015306-us58wwmp 4031 13 leaks leak NNS cord-015306-us58wwmp 4031 14 and and CC cord-015306-us58wwmp 4031 15 2 2 CD cord-015306-us58wwmp 4031 16 renal renal JJ cord-015306-us58wwmp 4031 17 vein vein NN cord-015306-us58wwmp 4031 18 thromboses thrombose NNS cord-015306-us58wwmp 4031 19 . . . cord-015306-us58wwmp 4032 1 Early early JJ cord-015306-us58wwmp 4032 2 post post JJ cord-015306-us58wwmp 4032 3 - - JJ cord-015306-us58wwmp 4032 4 operative operative JJ cord-015306-us58wwmp 4032 5 medical medical JJ cord-015306-us58wwmp 4032 6 complications complication NNS cord-015306-us58wwmp 4032 7 included include VBD cord-015306-us58wwmp 4032 8 hypertension hypertension NN cord-015306-us58wwmp 4032 9 ( ( -LRB- cord-015306-us58wwmp 4032 10 47 47 CD cord-015306-us58wwmp 4032 11 ) ) -RRB- cord-015306-us58wwmp 4032 12 , , , cord-015306-us58wwmp 4032 13 pulmonary pulmonary JJ cord-015306-us58wwmp 4032 14 oedema oedema NN cord-015306-us58wwmp 4032 15 ( ( -LRB- cord-015306-us58wwmp 4032 16 13 13 CD cord-015306-us58wwmp 4032 17 ) ) -RRB- cord-015306-us58wwmp 4032 18 , , , cord-015306-us58wwmp 4032 19 seizures seizure NNS cord-015306-us58wwmp 4032 20 ( ( -LRB- cord-015306-us58wwmp 4032 21 9 9 CD cord-015306-us58wwmp 4032 22 ) ) -RRB- cord-015306-us58wwmp 4032 23 , , , cord-015306-us58wwmp 4032 24 reaction reaction NN cord-015306-us58wwmp 4032 25 to to IN cord-015306-us58wwmp 4032 26 Basiliximab Basiliximab NNP cord-015306-us58wwmp 4032 27 ( ( -LRB- cord-015306-us58wwmp 4032 28 3 3 CD cord-015306-us58wwmp 4032 29 ) ) -RRB- cord-015306-us58wwmp 4032 30 , , , cord-015306-us58wwmp 4032 31 sepsis sepsis NN cord-015306-us58wwmp 4032 32 ( ( -LRB- cord-015306-us58wwmp 4032 33 5 5 CD cord-015306-us58wwmp 4032 34 ) ) -RRB- cord-015306-us58wwmp 4032 35 , , , cord-015306-us58wwmp 4032 36 acute acute JJ cord-015306-us58wwmp 4032 37 tubular tubular JJ cord-015306-us58wwmp 4032 38 necrosis necrosis NN cord-015306-us58wwmp 4032 39 ( ( -LRB- cord-015306-us58wwmp 4032 40 8) 8) NNP cord-015306-us58wwmp 4032 41 , , , cord-015306-us58wwmp 4032 42 delayed delay VBN cord-015306-us58wwmp 4032 43 graft graft NN cord-015306-us58wwmp 4032 44 function function NN cord-015306-us58wwmp 4032 45 ( ( -LRB- cord-015306-us58wwmp 4032 46 5 5 CD cord-015306-us58wwmp 4032 47 ) ) -RRB- cord-015306-us58wwmp 4032 48 , , , cord-015306-us58wwmp 4032 49 acute acute JJ cord-015306-us58wwmp 4032 50 rejection rejection NN cord-015306-us58wwmp 4032 51 ( ( -LRB- cord-015306-us58wwmp 4032 52 2 2 CD cord-015306-us58wwmp 4032 53 ) ) -RRB- cord-015306-us58wwmp 4032 54 and and CC cord-015306-us58wwmp 4032 55 diabetic diabetic JJ cord-015306-us58wwmp 4032 56 ketoacidosis ketoacidosis NN cord-015306-us58wwmp 4032 57 ( ( -LRB- cord-015306-us58wwmp 4032 58 1 1 CD cord-015306-us58wwmp 4032 59 ) ) -RRB- cord-015306-us58wwmp 4032 60 . . . cord-015306-us58wwmp 4033 1 Primary primary JJ cord-015306-us58wwmp 4033 2 EBV EBV NNP cord-015306-us58wwmp 4033 3 infection infection NN cord-015306-us58wwmp 4033 4 occurred occur VBD cord-015306-us58wwmp 4033 5 in in IN cord-015306-us58wwmp 4033 6 38 38 CD cord-015306-us58wwmp 4033 7 patients patient NNS cord-015306-us58wwmp 4033 8 -1 -1 NN cord-015306-us58wwmp 4033 9 developed developed JJ cord-015306-us58wwmp 4033 10 PTLD PTLD NNP cord-015306-us58wwmp 4033 11 . . . cord-015306-us58wwmp 4034 1 There there EX cord-015306-us58wwmp 4034 2 were be VBD cord-015306-us58wwmp 4034 3 9 9 CD cord-015306-us58wwmp 4034 4 ( ( -LRB- cord-015306-us58wwmp 4034 5 12 12 CD cord-015306-us58wwmp 4034 6 % % NN cord-015306-us58wwmp 4034 7 ) ) -RRB- cord-015306-us58wwmp 4034 8 graft graft NN cord-015306-us58wwmp 4034 9 failures failure NNS cord-015306-us58wwmp 4034 10 ; ; : cord-015306-us58wwmp 4034 11 renal renal JJ cord-015306-us58wwmp 4034 12 vein vein NN cord-015306-us58wwmp 4034 13 thrombosis thrombosis NN cord-015306-us58wwmp 4034 14 ( ( -LRB- cord-015306-us58wwmp 4034 15 2 2 CD cord-015306-us58wwmp 4034 16 ) ) -RRB- cord-015306-us58wwmp 4034 17 , , , cord-015306-us58wwmp 4034 18 acute acute JJ cord-015306-us58wwmp 4034 19 humoral humoral JJ cord-015306-us58wwmp 4034 20 rejection rejection NN cord-015306-us58wwmp 4034 21 ( ( -LRB- cord-015306-us58wwmp 4034 22 1 1 CD cord-015306-us58wwmp 4034 23 ) ) -RRB- cord-015306-us58wwmp 4034 24 , , , cord-015306-us58wwmp 4034 25 acute acute JJ cord-015306-us58wwmp 4034 26 tubulointerstitial tubulointerstitial JJ cord-015306-us58wwmp 4034 27 nephritis nephritis NN cord-015306-us58wwmp 4034 28 and and CC cord-015306-us58wwmp 4034 29 tacrolimus tacrolimus NN cord-015306-us58wwmp 4034 30 toxicity toxicity NN cord-015306-us58wwmp 4034 31 ( ( -LRB- cord-015306-us58wwmp 4034 32 1 1 CD cord-015306-us58wwmp 4034 33 ) ) -RRB- cord-015306-us58wwmp 4034 34 , , , cord-015306-us58wwmp 4034 35 de de NNP cord-015306-us58wwmp 4034 36 - - JJ cord-015306-us58wwmp 4034 37 novo novo JJ cord-015306-us58wwmp 4034 38 acute acute JJ cord-015306-us58wwmp 4034 39 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 4034 40 ( ( -LRB- cord-015306-us58wwmp 4034 41 1 1 CD cord-015306-us58wwmp 4034 42 ) ) -RRB- cord-015306-us58wwmp 4034 43 , , , cord-015306-us58wwmp 4034 44 chronic chronic JJ cord-015306-us58wwmp 4034 45 rejection rejection NN cord-015306-us58wwmp 4034 46 ( ( -LRB- cord-015306-us58wwmp 4034 47 2 2 CD cord-015306-us58wwmp 4034 48 ) ) -RRB- cord-015306-us58wwmp 4034 49 and and CC cord-015306-us58wwmp 4034 50 non non JJ cord-015306-us58wwmp 4034 51 - - JJ cord-015306-us58wwmp 4034 52 compliance compliance JJ cord-015306-us58wwmp 4034 53 ( ( -LRB- cord-015306-us58wwmp 4034 54 2 2 CD cord-015306-us58wwmp 4034 55 ) ) -RRB- cord-015306-us58wwmp 4034 56 . . . cord-015306-us58wwmp 4035 1 Graft graft NN cord-015306-us58wwmp 4035 2 survival survival NN cord-015306-us58wwmp 4035 3 rates rate NNS cord-015306-us58wwmp 4035 4 were be VBD cord-015306-us58wwmp 4035 5 95 95 CD cord-015306-us58wwmp 4035 6 % % NN cord-015306-us58wwmp 4035 7 at at IN cord-015306-us58wwmp 4035 8 one one CD cord-015306-us58wwmp 4035 9 year year NN cord-015306-us58wwmp 4035 10 , , , cord-015306-us58wwmp 4035 11 93 93 CD cord-015306-us58wwmp 4035 12 % % NN cord-015306-us58wwmp 4035 13 at at IN cord-015306-us58wwmp 4035 14 3 3 CD cord-015306-us58wwmp 4035 15 years year NNS cord-015306-us58wwmp 4035 16 , , , cord-015306-us58wwmp 4035 17 89 89 CD cord-015306-us58wwmp 4035 18 % % NN cord-015306-us58wwmp 4035 19 at at IN cord-015306-us58wwmp 4035 20 5 5 CD cord-015306-us58wwmp 4035 21 years year NNS cord-015306-us58wwmp 4035 22 and and CC cord-015306-us58wwmp 4035 23 88 88 CD cord-015306-us58wwmp 4035 24 % % NN cord-015306-us58wwmp 4035 25 at at IN cord-015306-us58wwmp 4035 26 10 10 CD cord-015306-us58wwmp 4035 27 years year NNS cord-015306-us58wwmp 4035 28 . . . cord-015306-us58wwmp 4036 1 Patient patient JJ cord-015306-us58wwmp 4036 2 survival survival NN cord-015306-us58wwmp 4036 3 was be VBD cord-015306-us58wwmp 4036 4 100 100 CD cord-015306-us58wwmp 4036 5 % % NN cord-015306-us58wwmp 4036 6 at at IN cord-015306-us58wwmp 4036 7 10 10 CD cord-015306-us58wwmp 4036 8 years year NNS cord-015306-us58wwmp 4036 9 . . . cord-015306-us58wwmp 4037 1 Conclusion conclusion NN cord-015306-us58wwmp 4037 2 : : : cord-015306-us58wwmp 4038 1 Our -PRON- PRP$ cord-015306-us58wwmp 4038 2 outcomes outcome NNS cord-015306-us58wwmp 4038 3 compare compare VBP cord-015306-us58wwmp 4038 4 well well RB cord-015306-us58wwmp 4038 5 with with IN cord-015306-us58wwmp 4038 6 international international JJ cord-015306-us58wwmp 4038 7 figures figure NNS cord-015306-us58wwmp 4038 8 A a DT cord-015306-us58wwmp 4038 9 Desensitisation Desensitisation NNP cord-015306-us58wwmp 4038 10 Program Program NNP cord-015306-us58wwmp 4038 11 for for IN cord-015306-us58wwmp 4038 12 Paediatric Paediatric NNP cord-015306-us58wwmp 4038 13 Renal Renal NNP cord-015306-us58wwmp 4038 14 Transplant Transplant NNP cord-015306-us58wwmp 4038 15 Patients Patients NNP cord-015306-us58wwmp 4038 16 in in IN cord-015306-us58wwmp 4038 17 NSW NSW NNP cord-015306-us58wwmp 4039 1 One one CD cord-015306-us58wwmp 4039 2 child child NN cord-015306-us58wwmp 4039 3 received receive VBD cord-015306-us58wwmp 4039 4 ATG ATG NNP cord-015306-us58wwmp 4039 5 in in IN cord-015306-us58wwmp 4039 6 addition addition NN cord-015306-us58wwmp 4039 7 . . . cord-015306-us58wwmp 4040 1 Results result NNS cord-015306-us58wwmp 4040 2 : : : cord-015306-us58wwmp 4040 3 Complications/ complications/ CD cord-015306-us58wwmp 4040 4 Patient patient JJ cord-015306-us58wwmp 4040 5 Outcomes:1 outcomes:1 NN cord-015306-us58wwmp 4040 6 : : : cord-015306-us58wwmp 4040 7 2 2 CD cord-015306-us58wwmp 4040 8 yo yo NN cord-015306-us58wwmp 4040 9 boy boy NN cord-015306-us58wwmp 4040 10 , , , cord-015306-us58wwmp 4040 11 donation donation NN cord-015306-us58wwmp 4040 12 from from IN cord-015306-us58wwmp 4040 13 mother mother NN cord-015306-us58wwmp 4040 14 . . . cord-015306-us58wwmp 4041 1 DSA DSA NNP cord-015306-us58wwmp 4041 2 antibodies antibody NNS cord-015306-us58wwmp 4041 3 MFI MFI NNP cord-015306-us58wwmp 4041 4 658 658 CD cord-015306-us58wwmp 4041 5 . . . cord-015306-us58wwmp 4042 1 No no DT cord-015306-us58wwmp 4042 2 complications complication NNS cord-015306-us58wwmp 4042 3 . . . cord-015306-us58wwmp 4043 1 No no DT cord-015306-us58wwmp 4043 2 infections infection NNS cord-015306-us58wwmp 4043 3 . . . cord-015306-us58wwmp 4044 1 Good good JJ cord-015306-us58wwmp 4044 2 renal renal JJ cord-015306-us58wwmp 4044 3 function function NN cord-015306-us58wwmp 4044 4 , , , cord-015306-us58wwmp 4044 5 creatinine creatinine NN cord-015306-us58wwmp 4044 6 45 45 CD cord-015306-us58wwmp 4044 7 at at IN cord-015306-us58wwmp 4044 8 2yrs 2yrs CD cord-015306-us58wwmp 4044 9 . . . cord-015306-us58wwmp 4045 1 2 2 LS cord-015306-us58wwmp 4045 2 : : : cord-015306-us58wwmp 4045 3 14 14 CD cord-015306-us58wwmp 4046 1 yo yo UH cord-015306-us58wwmp 4046 2 boy boy UH cord-015306-us58wwmp 4046 3 , , , cord-015306-us58wwmp 4046 4 previous previous JJ cord-015306-us58wwmp 4046 5 transplant transplant NN cord-015306-us58wwmp 4046 6 from from IN cord-015306-us58wwmp 4046 7 biological biological JJ cord-015306-us58wwmp 4046 8 father father NN cord-015306-us58wwmp 4046 9 . . . cord-015306-us58wwmp 4047 1 Donation donation NN cord-015306-us58wwmp 4047 2 from from IN cord-015306-us58wwmp 4047 3 foster foster NNP cord-015306-us58wwmp 4047 4 father father NNP cord-015306-us58wwmp 4047 5 . . . cord-015306-us58wwmp 4048 1 DSA DSA NNP cord-015306-us58wwmp 4048 2 antibodies antibody NNS cord-015306-us58wwmp 4048 3 MFI MFI NNP cord-015306-us58wwmp 4048 4 2602 2602 CD cord-015306-us58wwmp 4048 5 . . . cord-015306-us58wwmp 4049 1 Post post JJ cord-015306-us58wwmp 4049 2 operative operative JJ cord-015306-us58wwmp 4049 3 complication complication NN cord-015306-us58wwmp 4049 4 of of IN cord-015306-us58wwmp 4049 5 pseudomonas pseudomonas NNP cord-015306-us58wwmp 4049 6 pneumonia pneumonia NN cord-015306-us58wwmp 4049 7 / / SYM cord-015306-us58wwmp 4049 8 bronchiectasis bronchiectasis NN cord-015306-us58wwmp 4049 9 , , , cord-015306-us58wwmp 4049 10 CMV CMV NNP cord-015306-us58wwmp 4049 11 , , , cord-015306-us58wwmp 4050 1 Acute Acute NNP cord-015306-us58wwmp 4050 2 Cellular Cellular NNP cord-015306-us58wwmp 4050 3 Rejection Rejection NNP cord-015306-us58wwmp 4050 4 x2 x2 NN cord-015306-us58wwmp 4050 5 . . . cord-015306-us58wwmp 4051 1 Good good JJ cord-015306-us58wwmp 4051 2 renal renal JJ cord-015306-us58wwmp 4051 3 function function NN cord-015306-us58wwmp 4051 4 creatinine creatinine VBD cord-015306-us58wwmp 4051 5 120 120 CD cord-015306-us58wwmp 4051 6 at at IN cord-015306-us58wwmp 4051 7 1 1 CD cord-015306-us58wwmp 4051 8 yr yr NN cord-015306-us58wwmp 4051 9 . . . cord-015306-us58wwmp 4052 1 3 3 LS cord-015306-us58wwmp 4052 2 : : SYM cord-015306-us58wwmp 4052 3 17 17 CD cord-015306-us58wwmp 4052 4 yo yo UH cord-015306-us58wwmp 4052 5 boy boy NN cord-015306-us58wwmp 4052 6 , , , cord-015306-us58wwmp 4052 7 donation donation NN cord-015306-us58wwmp 4052 8 from from IN cord-015306-us58wwmp 4052 9 father father NN cord-015306-us58wwmp 4052 10 . . . cord-015306-us58wwmp 4053 1 DSA DSA NNP cord-015306-us58wwmp 4053 2 antibodies antibody NNS cord-015306-us58wwmp 4053 3 MFI MFI NNP cord-015306-us58wwmp 4053 4 724 724 CD cord-015306-us58wwmp 4053 5 . . . cord-015306-us58wwmp 4054 1 Early early RB cord-015306-us58wwmp 4054 2 e e NN cord-015306-us58wwmp 4054 3 - - HYPH cord-015306-us58wwmp 4054 4 coli coli NN cord-015306-us58wwmp 4054 5 urine urine NN cord-015306-us58wwmp 4054 6 infection infection NN cord-015306-us58wwmp 4054 7 . . . cord-015306-us58wwmp 4055 1 No no DT cord-015306-us58wwmp 4055 2 other other JJ cord-015306-us58wwmp 4055 3 complications complication NNS cord-015306-us58wwmp 4055 4 , , , cord-015306-us58wwmp 4055 5 creatinine creatinine NN cord-015306-us58wwmp 4055 6 117 117 CD cord-015306-us58wwmp 4055 7 at at IN cord-015306-us58wwmp 4055 8 1 1 CD cord-015306-us58wwmp 4055 9 yr yr NN cord-015306-us58wwmp 4055 10 . . NN cord-015306-us58wwmp 4055 11 4 4 CD cord-015306-us58wwmp 4055 12 : : : cord-015306-us58wwmp 4055 13 14 14 CD cord-015306-us58wwmp 4055 14 yo yo NNP cord-015306-us58wwmp 4055 15 girl girl NN cord-015306-us58wwmp 4055 16 , , , cord-015306-us58wwmp 4055 17 recipient recipient NN cord-015306-us58wwmp 4055 18 of of IN cord-015306-us58wwmp 4055 19 3 3 CD cord-015306-us58wwmp 4055 20 liver liver NN cord-015306-us58wwmp 4055 21 transplants transplant NNS cord-015306-us58wwmp 4055 22 . . . cord-015306-us58wwmp 4056 1 Maternal maternal JJ cord-015306-us58wwmp 4056 2 donor donor NN cord-015306-us58wwmp 4056 3 with with IN cord-015306-us58wwmp 4056 4 positive positive JJ cord-015306-us58wwmp 4056 5 B b NN cord-015306-us58wwmp 4056 6 cell cell NN cord-015306-us58wwmp 4056 7 CxM CxM NNS cord-015306-us58wwmp 4056 8 and and CC cord-015306-us58wwmp 4056 9 DSA DSA NNP cord-015306-us58wwmp 4056 10 MFI MFI NNP cord-015306-us58wwmp 4056 11 6488 6488 CD cord-015306-us58wwmp 4056 12 . . . cord-015306-us58wwmp 4057 1 No no DT cord-015306-us58wwmp 4057 2 complications complication NNS cord-015306-us58wwmp 4057 3 . . . cord-015306-us58wwmp 4058 1 Good good JJ cord-015306-us58wwmp 4058 2 renal renal JJ cord-015306-us58wwmp 4058 3 function function NN cord-015306-us58wwmp 4059 1 Four four CD cord-015306-us58wwmp 4059 2 of of IN cord-015306-us58wwmp 4059 3 them -PRON- PRP cord-015306-us58wwmp 4059 4 had have VBD cord-015306-us58wwmp 4059 5 subsequently subsequently RB cord-015306-us58wwmp 4059 6 increasing increase VBG cord-015306-us58wwmp 4059 7 needs need NNS cord-015306-us58wwmp 4059 8 in in IN cord-015306-us58wwmp 4059 9 bicarbonate bicarbonate NN cord-015306-us58wwmp 4059 10 and/or and/or CC cord-015306-us58wwmp 4059 11 sodium sodium NN cord-015306-us58wwmp 4059 12 supplementation supplementation NN cord-015306-us58wwmp 4059 13 , , , cord-015306-us58wwmp 4059 14 and and CC cord-015306-us58wwmp 4059 15 F F NNP cord-015306-us58wwmp 4059 16 was be VBD cord-015306-us58wwmp 4059 17 reintroduced reintroduce VBN cord-015306-us58wwmp 4059 18 in in IN cord-015306-us58wwmp 4059 19 3 3 CD cord-015306-us58wwmp 4059 20 of of IN cord-015306-us58wwmp 4059 21 them -PRON- PRP cord-015306-us58wwmp 4059 22 . . . cord-015306-us58wwmp 4060 1 Conclusion conclusion NN cord-015306-us58wwmp 4060 2 : : : cord-015306-us58wwmp 4061 1 F F NNP cord-015306-us58wwmp 4061 2 is be VBZ cord-015306-us58wwmp 4061 3 effective effective JJ cord-015306-us58wwmp 4061 4 in in IN cord-015306-us58wwmp 4061 5 most most JJS cord-015306-us58wwmp 4061 6 cases case NNS cord-015306-us58wwmp 4061 7 of of IN cord-015306-us58wwmp 4061 8 severe severe JJ cord-015306-us58wwmp 4061 9 tubulopathy tubulopathy NNP cord-015306-us58wwmp 4061 10 after after IN cord-015306-us58wwmp 4061 11 RTx RTx NNS cord-015306-us58wwmp 4061 12 . . . cord-015306-us58wwmp 4062 1 However however RB cord-015306-us58wwmp 4062 2 , , , cord-015306-us58wwmp 4062 3 side side NN cord-015306-us58wwmp 4062 4 - - HYPH cord-015306-us58wwmp 4062 5 effects effect NNS cord-015306-us58wwmp 4062 6 can can MD cord-015306-us58wwmp 4062 7 occur occur VB cord-015306-us58wwmp 4062 8 . . . cord-015306-us58wwmp 4063 1 Further further JJ cord-015306-us58wwmp 4063 2 prospective prospective JJ cord-015306-us58wwmp 4063 3 studies study NNS cord-015306-us58wwmp 4063 4 are be VBP cord-015306-us58wwmp 4063 5 needed need VBN cord-015306-us58wwmp 4063 6 to to TO cord-015306-us58wwmp 4063 7 validate validate VB cord-015306-us58wwmp 4063 8 this this DT cord-015306-us58wwmp 4063 9 indication indication NN cord-015306-us58wwmp 4063 10 Methods method NNS cord-015306-us58wwmp 4063 11 : : : cord-015306-us58wwmp 4063 12 Eighty eighty CD cord-015306-us58wwmp 4063 13 - - HYPH cord-015306-us58wwmp 4063 14 one one CD cord-015306-us58wwmp 4063 15 ( ( -LRB- cord-015306-us58wwmp 4063 16 F F NNP cord-015306-us58wwmp 4063 17 / / SYM cord-015306-us58wwmp 4063 18 M M NNP cord-015306-us58wwmp 4063 19 : : : cord-015306-us58wwmp 4063 20 41/40)pediatrictransplant 41/40)pediatrictransplant CD cord-015306-us58wwmp 4064 1 patients patient NNS cord-015306-us58wwmp 4064 2 were be VBD cord-015306-us58wwmp 4064 3 included include VBN cord-015306-us58wwmp 4064 4 to to IN cord-015306-us58wwmp 4064 5 the the DT cord-015306-us58wwmp 4064 6 study study NN cord-015306-us58wwmp 4064 7 . . . cord-015306-us58wwmp 4065 1 Demographic demographic JJ cord-015306-us58wwmp 4065 2 characteristics characteristic NNS cord-015306-us58wwmp 4065 3 and and CC cord-015306-us58wwmp 4065 4 laboratory laboratory NN cord-015306-us58wwmp 4065 5 parameters parameter NNS cord-015306-us58wwmp 4065 6 were be VBD cord-015306-us58wwmp 4065 7 recorded record VBN cord-015306-us58wwmp 4065 8 . . . cord-015306-us58wwmp 4066 1 Risk risk NN cord-015306-us58wwmp 4066 2 factors factor NNS cord-015306-us58wwmp 4066 3 for for IN cord-015306-us58wwmp 4066 4 hyperuricemia hyperuricemia NN cord-015306-us58wwmp 4066 5 and and CC cord-015306-us58wwmp 4066 6 the the DT cord-015306-us58wwmp 4066 7 effects effect NNS cord-015306-us58wwmp 4066 8 of of IN cord-015306-us58wwmp 4066 9 plasma plasma NN cord-015306-us58wwmp 4066 10 uric uric NN cord-015306-us58wwmp 4066 11 acid acid NN cord-015306-us58wwmp 4066 12 levels level NNS cord-015306-us58wwmp 4066 13 at at IN cord-015306-us58wwmp 4066 14 3 3 CD cord-015306-us58wwmp 4066 15 rd rd NN cord-015306-us58wwmp 4066 16 and and CC cord-015306-us58wwmp 4066 17 6 6 CD cord-015306-us58wwmp 4066 18 t t NN cord-015306-us58wwmp 4066 19 h h NN cord-015306-us58wwmp 4066 20 months month NNS cord-015306-us58wwmp 4066 21 , , , cord-015306-us58wwmp 4066 22 1 1 CD cord-015306-us58wwmp 4066 23 st st NNS cord-015306-us58wwmp 4066 24 and and CC cord-015306-us58wwmp 4066 25 3 3 CD cord-015306-us58wwmp 4066 26 th th XX cord-015306-us58wwmp 4066 27 years year NNS cord-015306-us58wwmp 4066 28 on on IN cord-015306-us58wwmp 4066 29 allograft allograft NN cord-015306-us58wwmp 4066 30 outcomes outcome NNS cord-015306-us58wwmp 4066 31 were be VBD cord-015306-us58wwmp 4066 32 evaluated evaluate VBN cord-015306-us58wwmp 4066 33 . . . cord-015306-us58wwmp 4067 1 Results result NNS cord-015306-us58wwmp 4067 2 : : : cord-015306-us58wwmp 4068 1 Mean mean JJ cord-015306-us58wwmp 4068 2 age age NN cord-015306-us58wwmp 4068 3 was be VBD cord-015306-us58wwmp 4068 4 16.9±5.6 16.9±5.6 CD cord-015306-us58wwmp 4068 5 years year NNS cord-015306-us58wwmp 4068 6 . . . cord-015306-us58wwmp 4069 1 Mean mean JJ cord-015306-us58wwmp 4069 2 follow follow NN cord-015306-us58wwmp 4069 3 - - HYPH cord-015306-us58wwmp 4069 4 up up NN cord-015306-us58wwmp 4069 5 time time NN cord-015306-us58wwmp 4069 6 after after IN cord-015306-us58wwmp 4069 7 transplant transplant NN cord-015306-us58wwmp 4069 8 was be VBD cord-015306-us58wwmp 4069 9 3.5±0.47 3.5±0.47 CD cord-015306-us58wwmp 4069 10 years year NNS cord-015306-us58wwmp 4069 11 . . . cord-015306-us58wwmp 4070 1 Hyperuricemia Hyperuricemia NNP cord-015306-us58wwmp 4070 2 was be VBD cord-015306-us58wwmp 4070 3 detected detect VBN cord-015306-us58wwmp 4070 4 in in IN cord-015306-us58wwmp 4070 5 17.6 17.6 CD cord-015306-us58wwmp 4070 6 % % NN cord-015306-us58wwmp 4070 7 of of IN cord-015306-us58wwmp 4070 8 patients patient NNS cord-015306-us58wwmp 4070 9 . . . cord-015306-us58wwmp 4071 1 A a DT cord-015306-us58wwmp 4071 2 significant significant JJ cord-015306-us58wwmp 4071 3 negative negative JJ cord-015306-us58wwmp 4071 4 correlation correlation NN cord-015306-us58wwmp 4071 5 was be VBD cord-015306-us58wwmp 4071 6 found find VBN cord-015306-us58wwmp 4071 7 between between IN cord-015306-us58wwmp 4071 8 6 6 CD cord-015306-us58wwmp 4071 9 th th XX cord-015306-us58wwmp 4071 10 month month NN cord-015306-us58wwmp 4071 11 uric uric NN cord-015306-us58wwmp 4071 12 acid acid NN cord-015306-us58wwmp 4071 13 leveland leveland NNP cord-015306-us58wwmp 4071 14 3 3 CD cord-015306-us58wwmp 4071 15 th th XX cord-015306-us58wwmp 4071 16 year year NN cord-015306-us58wwmp 4071 17 of of IN cord-015306-us58wwmp 4071 18 GFR GFR NNP cord-015306-us58wwmp 4071 19 value value NN cord-015306-us58wwmp 4071 20 ( ( -LRB- cord-015306-us58wwmp 4071 21 r r NN cord-015306-us58wwmp 4071 22 = = SYM cord-015306-us58wwmp 4071 23 -0.33 -0.33 NNS cord-015306-us58wwmp 4071 24 , , , cord-015306-us58wwmp 4071 25 p p NN cord-015306-us58wwmp 4071 26 = = SYM cord-015306-us58wwmp 4071 27 0.04 0.04 CD cord-015306-us58wwmp 4071 28 and and CC cord-015306-us58wwmp 4071 29 r r NN cord-015306-us58wwmp 4071 30 = = SYM cord-015306-us58wwmp 4071 31 -0.33 -0.33 NNS cord-015306-us58wwmp 4071 32 , , , cord-015306-us58wwmp 4071 33 p p NN cord-015306-us58wwmp 4071 34 = = SYM cord-015306-us58wwmp 4071 35 0.017 0.017 CD cord-015306-us58wwmp 4071 36 ) ) -RRB- cord-015306-us58wwmp 4071 37 . . . cord-015306-us58wwmp 4072 1 A a DT cord-015306-us58wwmp 4072 2 significant significant JJ cord-015306-us58wwmp 4072 3 positive positive JJ cord-015306-us58wwmp 4072 4 correlation correlation NN cord-015306-us58wwmp 4072 5 between between IN cord-015306-us58wwmp 4072 6 3 3 CD cord-015306-us58wwmp 4072 7 th th XX cord-015306-us58wwmp 4072 8 and and CC cord-015306-us58wwmp 4072 9 6 6 CD cord-015306-us58wwmp 4072 10 th th XX cord-015306-us58wwmp 4072 11 months month NNS cord-015306-us58wwmp 4072 12 uric uric NN cord-015306-us58wwmp 4072 13 acid acid NN cord-015306-us58wwmp 4072 14 levels level NNS cord-015306-us58wwmp 4073 1 and3 and3 NNP cord-015306-us58wwmp 4074 1 th th DT cord-015306-us58wwmp 4074 2 year year NN cord-015306-us58wwmp 4074 3 plasma plasma NN cord-015306-us58wwmp 4074 4 creatinine creatinine NN cord-015306-us58wwmp 4074 5 level level NN cord-015306-us58wwmp 4074 6 was be VBD cord-015306-us58wwmp 4074 7 demonstrated demonstrate VBN cord-015306-us58wwmp 4074 8 Conclusion conclusion NN cord-015306-us58wwmp 4074 9 : : : cord-015306-us58wwmp 4074 10 Uric uric JJ cord-015306-us58wwmp 4074 11 acid acid NN cord-015306-us58wwmp 4074 12 levels level NNS cord-015306-us58wwmp 4074 13 may may MD cord-015306-us58wwmp 4074 14 have have VB cord-015306-us58wwmp 4074 15 predictive predictive JJ cord-015306-us58wwmp 4074 16 value value NN cord-015306-us58wwmp 4074 17 in in IN cord-015306-us58wwmp 4074 18 the the DT cord-015306-us58wwmp 4074 19 long long JJ cord-015306-us58wwmp 4074 20 term term NN cord-015306-us58wwmp 4074 21 assessment assessment NN cord-015306-us58wwmp 4074 22 of of IN cord-015306-us58wwmp 4074 23 renal renal JJ cord-015306-us58wwmp 4074 24 function function NN cord-015306-us58wwmp 4074 25 . . . cord-015306-us58wwmp 4075 1 Posttransplanthyperuricemia Posttransplanthyperuricemia NNP cord-015306-us58wwmp 4075 2 can can MD cord-015306-us58wwmp 4075 3 be be VB cord-015306-us58wwmp 4075 4 used use VBN cord-015306-us58wwmp 4075 5 as as IN cord-015306-us58wwmp 4075 6 a a DT cord-015306-us58wwmp 4075 7 long long JJ cord-015306-us58wwmp 4075 8 term term NN cord-015306-us58wwmp 4075 9 prognostic prognostic JJ cord-015306-us58wwmp 4075 10 marker marker NN cord-015306-us58wwmp 4075 11 of of IN cord-015306-us58wwmp 4075 12 poor poor JJ cord-015306-us58wwmp 4075 13 renal renal JJ cord-015306-us58wwmp 4075 14 outcome outcome NN cord-015306-us58wwmp 4075 15 . . . cord-015306-us58wwmp 4076 1 Patients patient NNS cord-015306-us58wwmp 4076 2 with with IN cord-015306-us58wwmp 4076 3 hyperuricemia hyperuricemia NN cord-015306-us58wwmp 4076 4 should should MD cord-015306-us58wwmp 4076 5 be be VB cord-015306-us58wwmp 4076 6 monitored monitor VBN cord-015306-us58wwmp 4076 7 closely closely RB cord-015306-us58wwmp 4076 8 for for IN cord-015306-us58wwmp 4076 9 renal renal JJ cord-015306-us58wwmp 4076 10 functions function NNS cord-015306-us58wwmp 4076 11 Abstract abstract JJ cord-015306-us58wwmp 4077 1 # # $ cord-015306-us58wwmp 4077 2 P p NN cord-015306-us58wwmp 4077 3 - - HYPH cord-015306-us58wwmp 4077 4 SAT447 SAT447 NNP cord-015306-us58wwmp 4077 5 Tuberculosis tuberculosis NN cord-015306-us58wwmp 4077 6 in in IN cord-015306-us58wwmp 4077 7 Paediatric Paediatric NNP cord-015306-us58wwmp 4077 8 Renal Renal NNP cord-015306-us58wwmp 4077 9 Transplant Transplant NNP cord-015306-us58wwmp 4077 10 Patients patient NNS cord-015306-us58wwmp 4077 11 -Single -single IN cord-015306-us58wwmp 4077 12 Centre Centre NNP cord-015306-us58wwmp 4077 13 Experience experience NN cord-015306-us58wwmp 4077 14 Methods Methods NNPS cord-015306-us58wwmp 4077 15 : : : cord-015306-us58wwmp 4077 16 Retrospective retrospective JJ cord-015306-us58wwmp 4077 17 descriptive descriptive JJ cord-015306-us58wwmp 4077 18 folder folder NN cord-015306-us58wwmp 4077 19 review review NN cord-015306-us58wwmp 4077 20 of of IN cord-015306-us58wwmp 4077 21 TB TB NNP cord-015306-us58wwmp 4077 22 in in IN cord-015306-us58wwmp 4077 23 Paediatric Paediatric NNP cord-015306-us58wwmp 4077 24 Renal Renal NNP cord-015306-us58wwmp 4077 25 Transplantation Transplantation NNP cord-015306-us58wwmp 4077 26 at at IN cord-015306-us58wwmp 4077 27 Red Red NNP cord-015306-us58wwmp 4077 28 Cross Cross NNP cord-015306-us58wwmp 4077 29 Children Children NNP cord-015306-us58wwmp 4077 30 's 's POS cord-015306-us58wwmp 4077 31 Hospital Hospital NNP cord-015306-us58wwmp 4077 32 , , , cord-015306-us58wwmp 4077 33 University University NNP cord-015306-us58wwmp 4077 34 of of IN cord-015306-us58wwmp 4077 35 Cape Cape NNP cord-015306-us58wwmp 4077 36 Town Town NNP cord-015306-us58wwmp 4077 37 from from IN cord-015306-us58wwmp 4077 38 1994 1994 CD cord-015306-us58wwmp 4077 39 -2012 -2012 NN cord-015306-us58wwmp 4077 40 . . . cord-015306-us58wwmp 4078 1 Results result NNS cord-015306-us58wwmp 4078 2 : : : cord-015306-us58wwmp 4078 3 14 14 CD cord-015306-us58wwmp 4078 4 paediatric paediatric JJ cord-015306-us58wwmp 4078 5 renal renal JJ cord-015306-us58wwmp 4078 6 transplant transplant NN cord-015306-us58wwmp 4078 7 with with IN cord-015306-us58wwmp 4078 8 TB TB NNP cord-015306-us58wwmp 4078 9 identified identify VBN cord-015306-us58wwmp 4078 10 . . . cord-015306-us58wwmp 4079 1 Male male JJ cord-015306-us58wwmp 4079 2 11 11 CD cord-015306-us58wwmp 4079 3 : : : cord-015306-us58wwmp 4079 4 Female female JJ cord-015306-us58wwmp 4079 5 3 3 CD cord-015306-us58wwmp 4079 6 . . . cord-015306-us58wwmp 4080 1 Ages age NNS cord-015306-us58wwmp 4080 2 3.4 3.4 CD cord-015306-us58wwmp 4080 3 -18.8yrs(mean -18.8yrs(mean SYM cord-015306-us58wwmp 4080 4 12.0 12.0 CD cord-015306-us58wwmp 4080 5 ; ; : cord-015306-us58wwmp 4080 6 median median NN cord-015306-us58wwmp 4080 7 13.2 13.2 CD cord-015306-us58wwmp 4080 8 ) ) -RRB- cord-015306-us58wwmp 4080 9 . . . cord-015306-us58wwmp 4081 1 All all DT cord-015306-us58wwmp 4081 2 patients patient NNS cord-015306-us58wwmp 4081 3 screened screen VBN cord-015306-us58wwmp 4081 4 for for IN cord-015306-us58wwmp 4081 5 TB TB NNP cord-015306-us58wwmp 4081 6 prior prior RB cord-015306-us58wwmp 4081 7 to to IN cord-015306-us58wwmp 4081 8 transplant transplant NN cord-015306-us58wwmp 4081 9 Polycystic polycystic JJ cord-015306-us58wwmp 4081 10 Kidney Kidney NNP cord-015306-us58wwmp 4081 11 Disease Disease NNP cord-015306-us58wwmp 4081 12 , , , cord-015306-us58wwmp 4081 13 2 2 CD cord-015306-us58wwmp 4081 14 Dysplasia dysplasia NN cord-015306-us58wwmp 4081 15 , , , cord-015306-us58wwmp 4081 16 2 2 CD cord-015306-us58wwmp 4081 17 Chronic Chronic NNP cord-015306-us58wwmp 4081 18 Glomerular Glomerular NNP cord-015306-us58wwmp 4081 19 Nephritis nephritis NN cord-015306-us58wwmp 4081 20 , , , cord-015306-us58wwmp 4081 21 2 2 CD cord-015306-us58wwmp 4081 22 unknown unknown JJ cord-015306-us58wwmp 4081 23 cause cause NN cord-015306-us58wwmp 4081 24 , , , cord-015306-us58wwmp 4081 25 1 1 CD cord-015306-us58wwmp 4081 26 Systemic Systemic NNP cord-015306-us58wwmp 4081 27 Lupus Lupus NNP cord-015306-us58wwmp 4081 28 Erythematosis Erythematosis NNP cord-015306-us58wwmp 4081 29 and and CC cord-015306-us58wwmp 4081 30 1 1 CD cord-015306-us58wwmp 4082 1 All all DT cord-015306-us58wwmp 4082 2 patients patient NNS cord-015306-us58wwmp 4082 3 were be VBD cord-015306-us58wwmp 4082 4 on on IN cord-015306-us58wwmp 4082 5 steroids steroid NNS cord-015306-us58wwmp 4082 6 and and CC cord-015306-us58wwmp 4082 7 8 8 CD cord-015306-us58wwmp 4082 8 had have VBD cord-015306-us58wwmp 4082 9 recent recent JJ cord-015306-us58wwmp 4082 10 intensification intensification NN cord-015306-us58wwmp 4082 11 of of IN cord-015306-us58wwmp 4082 12 immunosuppression immunosuppression NN cord-015306-us58wwmp 4082 13 . . . cord-015306-us58wwmp 4083 1 TB TB NNP cord-015306-us58wwmp 4083 2 treatment treatment NN cord-015306-us58wwmp 4083 3 included include VBD cord-015306-us58wwmp 4083 4 conventional conventional JJ cord-015306-us58wwmp 4083 5 drugs drug NNS cord-015306-us58wwmp 4083 6 in in IN cord-015306-us58wwmp 4083 7 all all DT cord-015306-us58wwmp 4083 8 but but CC cord-015306-us58wwmp 4083 9 1 1 CD cord-015306-us58wwmp 4083 10 case case NN cord-015306-us58wwmp 4083 11 . . . cord-015306-us58wwmp 4084 1 Levels level NNS cord-015306-us58wwmp 4084 2 of of IN cord-015306-us58wwmp 4084 3 Calcineurin Calcineurin NNP cord-015306-us58wwmp 4084 4 inhibitors inhibitor NNS cord-015306-us58wwmp 4084 5 were be VBD cord-015306-us58wwmp 4084 6 affected affect VBN cord-015306-us58wwmp 4084 7 in in IN cord-015306-us58wwmp 4084 8 12/14 12/14 CD cord-015306-us58wwmp 4084 9 patients patient NNS cord-015306-us58wwmp 4084 10 and and CC cord-015306-us58wwmp 4084 11 required require VBD cord-015306-us58wwmp 4084 12 increased increase VBD cord-015306-us58wwmp 4084 13 dosing(up dosing(up CD cord-015306-us58wwmp 4084 14 to to IN cord-015306-us58wwmp 4084 15 3 3 CD cord-015306-us58wwmp 4084 16 times time NNS cord-015306-us58wwmp 4084 17 baseline baseline JJ cord-015306-us58wwmp 4084 18 ) ) -RRB- cord-015306-us58wwmp 4084 19 according accord VBG cord-015306-us58wwmp 4084 20 to to IN cord-015306-us58wwmp 4084 21 levels level NNS cord-015306-us58wwmp 4084 22 in in IN cord-015306-us58wwmp 4084 23 all all DT cord-015306-us58wwmp 4084 24 . . . cord-015306-us58wwmp 4085 1 Rejection rejection NN cord-015306-us58wwmp 4085 2 was be VBD cord-015306-us58wwmp 4085 3 seen see VBN cord-015306-us58wwmp 4085 4 in in IN cord-015306-us58wwmp 4085 5 7 7 CD cord-015306-us58wwmp 4085 6 patients(all patients(all NN cord-015306-us58wwmp 4085 7 biopsy biopsy JJ cord-015306-us58wwmp 4085 8 proven prove VBN cord-015306-us58wwmp 4085 9 ) ) -RRB- cord-015306-us58wwmp 4085 10 . . . cord-015306-us58wwmp 4086 1 Successful successful JJ cord-015306-us58wwmp 4086 2 treatment treatment NN cord-015306-us58wwmp 4086 3 of of IN cord-015306-us58wwmp 4086 4 TB TB NNP cord-015306-us58wwmp 4086 5 in in IN cord-015306-us58wwmp 4086 6 all all DT cord-015306-us58wwmp 4086 7 patients patient NNS cord-015306-us58wwmp 4086 8 with with IN cord-015306-us58wwmp 4086 9 retention retention NN cord-015306-us58wwmp 4086 10 of of IN cord-015306-us58wwmp 4086 11 graft graft NN cord-015306-us58wwmp 4086 12 . . . cord-015306-us58wwmp 4087 1 Graft graft NN cord-015306-us58wwmp 4087 2 and and CC cord-015306-us58wwmp 4087 3 patient patient JJ cord-015306-us58wwmp 4087 4 survival survival NN cord-015306-us58wwmp 4087 5 100 100 CD cord-015306-us58wwmp 4087 6 % % NN cord-015306-us58wwmp 4087 7 post post NN cord-015306-us58wwmp 4087 8 treatment treatment NN cord-015306-us58wwmp 4087 9 . . . cord-015306-us58wwmp 4088 1 Conclusion conclusion NN cord-015306-us58wwmp 4088 2 : : : cord-015306-us58wwmp 4089 1 TB TB NNP cord-015306-us58wwmp 4089 2 is be VBZ cord-015306-us58wwmp 4089 3 a a DT cord-015306-us58wwmp 4089 4 significant significant JJ cord-015306-us58wwmp 4089 5 problem problem NN cord-015306-us58wwmp 4089 6 in in IN cord-015306-us58wwmp 4089 7 paediatric paediatric JJ cord-015306-us58wwmp 4089 8 renal renal JJ cord-015306-us58wwmp 4089 9 transplants transplant NNS cord-015306-us58wwmp 4089 10 in in IN cord-015306-us58wwmp 4089 11 developing develop VBG cord-015306-us58wwmp 4089 12 countries country NNS cord-015306-us58wwmp 4089 13 . . . cord-015306-us58wwmp 4090 1 Our -PRON- PRP$ cord-015306-us58wwmp 4090 2 series series NN cord-015306-us58wwmp 4090 3 shows show VBZ cord-015306-us58wwmp 4090 4 that that IN cord-015306-us58wwmp 4090 5 with with IN cord-015306-us58wwmp 4090 6 careful careful JJ cord-015306-us58wwmp 4090 7 investigation investigation NN cord-015306-us58wwmp 4090 8 and and CC cord-015306-us58wwmp 4090 9 diagnosis diagnosis NN cord-015306-us58wwmp 4090 10 of of IN cord-015306-us58wwmp 4090 11 TB TB NNP cord-015306-us58wwmp 4090 12 as as RB cord-015306-us58wwmp 4090 13 well well RB cord-015306-us58wwmp 4090 14 as as IN cord-015306-us58wwmp 4090 15 careful careful JJ cord-015306-us58wwmp 4090 16 monitoring monitoring NN cord-015306-us58wwmp 4090 17 of of IN cord-015306-us58wwmp 4090 18 immunosuppressant immunosuppressant JJ cord-015306-us58wwmp 4090 19 levels level NNS cord-015306-us58wwmp 4090 20 Objective Objective NNP cord-015306-us58wwmp 4090 21 : : : cord-015306-us58wwmp 4090 22 To to TO cord-015306-us58wwmp 4090 23 evaluate evaluate VB cord-015306-us58wwmp 4090 24 the the DT cord-015306-us58wwmp 4090 25 reliability reliability NN cord-015306-us58wwmp 4090 26 , , , cord-015306-us58wwmp 4090 27 validity validity NN cord-015306-us58wwmp 4090 28 and and CC cord-015306-us58wwmp 4090 29 feasibility feasibility NN cord-015306-us58wwmp 4090 30 of of IN cord-015306-us58wwmp 4090 31 the the DT cord-015306-us58wwmp 4090 32 Persian persian JJ cord-015306-us58wwmp 4090 33 version version NN cord-015306-us58wwmp 4090 34 of of IN cord-015306-us58wwmp 4090 35 the the DT cord-015306-us58wwmp 4090 36 Pediatric Pediatric NNP cord-015306-us58wwmp 4090 37 Quality Quality NNP cord-015306-us58wwmp 4090 38 of of IN cord-015306-us58wwmp 4090 39 Life Life NNP cord-015306-us58wwmp 4090 40 inventory inventory NN cord-015306-us58wwmp 4090 41 ( ( -LRB- cord-015306-us58wwmp 4090 42 PedsQL PedsQL NNP cord-015306-us58wwmp 4090 43 TM TM NNP cord-015306-us58wwmp 4090 44 4.0TM 4.0tm CD cord-015306-us58wwmp 4090 45 4.0 4.0 CD cord-015306-us58wwmp 4090 46 ) ) -RRB- cord-015306-us58wwmp 4090 47 Generic Generic NNP cord-015306-us58wwmp 4090 48 Core Core NNP cord-015306-us58wwmp 4090 49 Scales Scales NNPS cord-015306-us58wwmp 4090 50 in in IN cord-015306-us58wwmp 4090 51 Iranian iranian JJ cord-015306-us58wwmp 4090 52 healthy healthy JJ cord-015306-us58wwmp 4090 53 students student NNS cord-015306-us58wwmp 4090 54 ages age NNS cord-015306-us58wwmp 4090 55 7 7 CD cord-015306-us58wwmp 4090 56 - - SYM cord-015306-us58wwmp 4090 57 15 15 CD cord-015306-us58wwmp 4090 58 and and CC cord-015306-us58wwmp 4090 59 chronically chronically RB cord-015306-us58wwmp 4090 60 ill ill JJ cord-015306-us58wwmp 4090 61 children child NNS cord-015306-us58wwmp 4090 62 ages age NNS cord-015306-us58wwmp 4090 63 2 2 CD cord-015306-us58wwmp 4090 64 - - SYM cord-015306-us58wwmp 4090 65 18 18 CD cord-015306-us58wwmp 4090 66 . . . cord-015306-us58wwmp 4091 1 Methods method NNS cord-015306-us58wwmp 4091 2 : : : cord-015306-us58wwmp 4091 3 We -PRON- PRP cord-015306-us58wwmp 4091 4 followed follow VBD cord-015306-us58wwmp 4091 5 the the DT cord-015306-us58wwmp 4091 6 translation translation NN cord-015306-us58wwmp 4091 7 methodology methodology NN cord-015306-us58wwmp 4091 8 proposed propose VBN cord-015306-us58wwmp 4091 9 by by IN cord-015306-us58wwmp 4091 10 developer developer NN cord-015306-us58wwmp 4091 11 to to TO cord-015306-us58wwmp 4091 12 validate validate VB cord-015306-us58wwmp 4091 13 Persian persian JJ cord-015306-us58wwmp 4091 14 version version NN cord-015306-us58wwmp 4091 15 of of IN cord-015306-us58wwmp 4091 16 PedsQL PedsQL NNP cord-015306-us58wwmp 4091 17 TM TM NNP cord-015306-us58wwmp 4091 18 4.0TM 4.0tm CD cord-015306-us58wwmp 4091 19 4.0 4.0 CD cord-015306-us58wwmp 4091 20 Generic Generic NNP cord-015306-us58wwmp 4091 21 Core Core NNP cord-015306-us58wwmp 4091 22 Scales Scales NNP cord-015306-us58wwmp 4091 23 for for IN cord-015306-us58wwmp 4091 24 children child NNS cord-015306-us58wwmp 4091 25 . . . cord-015306-us58wwmp 4092 1 Six six CD cord-015306-us58wwmp 4092 2 hundred hundred CD cord-015306-us58wwmp 4092 3 and and CC cord-015306-us58wwmp 4092 4 sixty sixty CD cord-015306-us58wwmp 4092 5 children child NNS cord-015306-us58wwmp 4092 6 and and CC cord-015306-us58wwmp 4092 7 adolescents adolescent NNS cord-015306-us58wwmp 4092 8 and and CC cord-015306-us58wwmp 4092 9 their -PRON- PRP$ cord-015306-us58wwmp 4092 10 parents parent NNS cord-015306-us58wwmp 4092 11 were be VBD cord-015306-us58wwmp 4092 12 enrolled enrol VBN cord-015306-us58wwmp 4092 13 . . . cord-015306-us58wwmp 4093 1 Sample sample NN cord-015306-us58wwmp 4093 2 of of IN cord-015306-us58wwmp 4093 3 160 160 CD cord-015306-us58wwmp 4093 4 healthy healthy JJ cord-015306-us58wwmp 4093 5 students student NNS cord-015306-us58wwmp 4093 6 were be VBD cord-015306-us58wwmp 4093 7 chosen choose VBN cord-015306-us58wwmp 4093 8 by by IN cord-015306-us58wwmp 4093 9 random random JJ cord-015306-us58wwmp 4093 10 cluster cluster NN cord-015306-us58wwmp 4093 11 method method NN cord-015306-us58wwmp 4093 12 between between IN cord-015306-us58wwmp 4093 13 4 4 CD cord-015306-us58wwmp 4093 14 regions region NNS cord-015306-us58wwmp 4093 15 of of IN cord-015306-us58wwmp 4093 16 Isfahan Isfahan NNP cord-015306-us58wwmp 4093 17 education education NN cord-015306-us58wwmp 4093 18 offices office NNS cord-015306-us58wwmp 4093 19 and and CC cord-015306-us58wwmp 4093 20 60 60 CD cord-015306-us58wwmp 4093 21 chronically chronically RB cord-015306-us58wwmp 4093 22 ill ill JJ cord-015306-us58wwmp 4093 23 children child NNS cord-015306-us58wwmp 4093 24 were be VBD cord-015306-us58wwmp 4093 25 recruited recruit VBN cord-015306-us58wwmp 4093 26 from from IN cord-015306-us58wwmp 4093 27 St. St. NNP cord-015306-us58wwmp 4093 28 Alzahra Alzahra NNP cord-015306-us58wwmp 4093 29 hospital hospital NN cord-015306-us58wwmp 4093 30 private private JJ cord-015306-us58wwmp 4093 31 clinics clinic NNS cord-015306-us58wwmp 4093 32 . . . cord-015306-us58wwmp 4094 1 The the DT cord-015306-us58wwmp 4094 2 questionnaires questionnaire NNS cord-015306-us58wwmp 4094 3 were be VBD cord-015306-us58wwmp 4094 4 fulfilled fulfil VBN cord-015306-us58wwmp 4094 5 by by IN cord-015306-us58wwmp 4094 6 the the DT cord-015306-us58wwmp 4094 7 participants participant NNS cord-015306-us58wwmp 4094 8 . . . cord-015306-us58wwmp 4095 1 Results result NNS cord-015306-us58wwmp 4095 2 : : : cord-015306-us58wwmp 4096 1 The the DT cord-015306-us58wwmp 4096 2 Persian persian JJ cord-015306-us58wwmp 4096 3 version version NN cord-015306-us58wwmp 4096 4 of of IN cord-015306-us58wwmp 4096 5 PedsQL PedsQL NNP cord-015306-us58wwmp 4096 6 TM TM NNP cord-015306-us58wwmp 4096 7 4.0TM 4.0tm CD cord-015306-us58wwmp 4096 8 4.0 4.0 CD cord-015306-us58wwmp 4096 9 Generic Generic NNP cord-015306-us58wwmp 4096 10 Core Core NNP cord-015306-us58wwmp 4096 11 Scales Scales NNP cord-015306-us58wwmp 4096 12 discriminated discriminate VBN cord-015306-us58wwmp 4096 13 between between IN cord-015306-us58wwmp 4096 14 healthy healthy JJ cord-015306-us58wwmp 4096 15 and and CC cord-015306-us58wwmp 4096 16 chronically chronically RB cord-015306-us58wwmp 4096 17 ill ill JJ cord-015306-us58wwmp 4096 18 children child NNS cord-015306-us58wwmp 4096 19 ( ( -LRB- cord-015306-us58wwmp 4096 20 healthy healthy JJ cord-015306-us58wwmp 4096 21 students student NNS cord-015306-us58wwmp 4096 22 mean mean VBP cord-015306-us58wwmp 4096 23 score score NN cord-015306-us58wwmp 4096 24 was be VBD cord-015306-us58wwmp 4096 25 12.3 12.3 CD cord-015306-us58wwmp 4096 26 better well JJR cord-015306-us58wwmp 4096 27 than than IN cord-015306-us58wwmp 4096 28 chronically chronically RB cord-015306-us58wwmp 4096 29 ill ill JJ cord-015306-us58wwmp 4096 30 children child NNS cord-015306-us58wwmp 4096 31 , , , cord-015306-us58wwmp 4096 32 P p NN cord-015306-us58wwmp 4096 33 < < XX cord-015306-us58wwmp 4096 34 0.001 0.001 CD cord-015306-us58wwmp 4096 35 ) ) -RRB- cord-015306-us58wwmp 4096 36 . . . cord-015306-us58wwmp 4097 1 Cronbachs cronbachs JJ cord-015306-us58wwmp 4097 2 alpha alpha NN cord-015306-us58wwmp 4097 3 internal internal JJ cord-015306-us58wwmp 4097 4 consistency consistency NN cord-015306-us58wwmp 4097 5 values value NNS cord-015306-us58wwmp 4097 6 exceeded exceed VBD cord-015306-us58wwmp 4097 7 0.7 0.7 CD cord-015306-us58wwmp 4097 8 for for IN cord-015306-us58wwmp 4097 9 children child NNS cord-015306-us58wwmp 4097 10 self self NN cord-015306-us58wwmp 4097 11 reports report NNS cord-015306-us58wwmp 4097 12 and and CC cord-015306-us58wwmp 4097 13 proxy proxy NN cord-015306-us58wwmp 4097 14 reports report NNS cord-015306-us58wwmp 4097 15 of of IN cord-015306-us58wwmp 4097 16 children child NNS cord-015306-us58wwmp 4097 17 5 5 CD cord-015306-us58wwmp 4097 18 - - SYM cord-015306-us58wwmp 4097 19 7 7 CD cord-015306-us58wwmp 4097 20 years year NNS cord-015306-us58wwmp 4097 21 old old JJ cord-015306-us58wwmp 4097 22 and and CC cord-015306-us58wwmp 4097 23 13 13 CD cord-015306-us58wwmp 4097 24 - - SYM cord-015306-us58wwmp 4097 25 18 18 CD cord-015306-us58wwmp 4097 26 years year NNS cord-015306-us58wwmp 4097 27 old old JJ cord-015306-us58wwmp 4097 28 . . . cord-015306-us58wwmp 4098 1 Reliability reliability NN cord-015306-us58wwmp 4098 2 of of IN cord-015306-us58wwmp 4098 3 proxy proxy NN cord-015306-us58wwmp 4098 4 reports report NNS cord-015306-us58wwmp 4098 5 for for IN cord-015306-us58wwmp 4098 6 2 2 CD cord-015306-us58wwmp 4098 7 - - SYM cord-015306-us58wwmp 4098 8 4 4 CD cord-015306-us58wwmp 4098 9 years year NNS cord-015306-us58wwmp 4098 10 old old JJ cord-015306-us58wwmp 4098 11 was be VBD cord-015306-us58wwmp 4098 12 much much RB cord-015306-us58wwmp 4098 13 lower low JJR cord-015306-us58wwmp 4098 14 than than IN cord-015306-us58wwmp 4098 15 0.7 0.7 CD cord-015306-us58wwmp 4098 16 . . . cord-015306-us58wwmp 4099 1 Although although IN cord-015306-us58wwmp 4099 2 , , , cord-015306-us58wwmp 4099 3 proxy proxy NN cord-015306-us58wwmp 4099 4 reports report NNS cord-015306-us58wwmp 4099 5 for for IN cord-015306-us58wwmp 4099 6 chronically chronically RB cord-015306-us58wwmp 4099 7 ill ill JJ cord-015306-us58wwmp 4099 8 children child NNS cord-015306-us58wwmp 4099 9 8 8 CD cord-015306-us58wwmp 4099 10 - - SYM cord-015306-us58wwmp 4099 11 12 12 CD cord-015306-us58wwmp 4099 12 years year NNS cord-015306-us58wwmp 4099 13 old old JJ cord-015306-us58wwmp 4099 14 was be VBD cord-015306-us58wwmp 4099 15 more more JJR cord-015306-us58wwmp 4099 16 than than IN cord-015306-us58wwmp 4099 17 0.7 0.7 CD cord-015306-us58wwmp 4099 18 , , , cord-015306-us58wwmp 4099 19 these these DT cord-015306-us58wwmp 4099 20 reports report NNS cord-015306-us58wwmp 4099 21 for for IN cord-015306-us58wwmp 4099 22 healthy healthy JJ cord-015306-us58wwmp 4099 23 children child NNS cord-015306-us58wwmp 4099 24 with with IN cord-015306-us58wwmp 4099 25 same same JJ cord-015306-us58wwmp 4099 26 age age NN cord-015306-us58wwmp 4099 27 group group NN cord-015306-us58wwmp 4099 28 was be VBD cord-015306-us58wwmp 4099 29 slightly slightly RB cord-015306-us58wwmp 4099 30 lower low JJR cord-015306-us58wwmp 4099 31 than than IN cord-015306-us58wwmp 4099 32 0.7 0.7 CD cord-015306-us58wwmp 4099 33 . . . cord-015306-us58wwmp 4100 1 Constructive constructive JJ cord-015306-us58wwmp 4100 2 , , , cord-015306-us58wwmp 4100 3 criterion criterion NN cord-015306-us58wwmp 4100 4 face face NN cord-015306-us58wwmp 4100 5 and and CC cord-015306-us58wwmp 4100 6 content content NN cord-015306-us58wwmp 4100 7 validity validity NN cord-015306-us58wwmp 4100 8 were be VBD cord-015306-us58wwmp 4100 9 acceptable acceptable JJ cord-015306-us58wwmp 4100 10 . . . cord-015306-us58wwmp 4101 1 In in IN cord-015306-us58wwmp 4101 2 addition addition NN cord-015306-us58wwmp 4101 3 , , , cord-015306-us58wwmp 4101 4 the the DT cord-015306-us58wwmp 4101 5 Persian persian JJ cord-015306-us58wwmp 4101 6 version version NN cord-015306-us58wwmp 4101 7 of of IN cord-015306-us58wwmp 4101 8 PedsQL PedsQL NNP cord-015306-us58wwmp 4101 9 TM TM NNP cord-015306-us58wwmp 4101 10 4.0TM 4.0tm CD cord-015306-us58wwmp 4102 1 4.0 4.0 CD cord-015306-us58wwmp 4102 2 Generic Generic NNP cord-015306-us58wwmp 4102 3 Core Core NNP cord-015306-us58wwmp 4102 4 Scales Scales NNP cord-015306-us58wwmp 4102 5 was be VBD cord-015306-us58wwmp 4102 6 feasible feasible JJ cord-015306-us58wwmp 4102 7 and and CC cord-015306-us58wwmp 4102 8 easy easy JJ cord-015306-us58wwmp 4102 9 to to TO cord-015306-us58wwmp 4102 10 complete complete VB cord-015306-us58wwmp 4102 11 . . . cord-015306-us58wwmp 4103 1 Conclusion conclusion NN cord-015306-us58wwmp 4103 2 : : : cord-015306-us58wwmp 4104 1 Results result NNS cord-015306-us58wwmp 4104 2 showed show VBD cord-015306-us58wwmp 4104 3 that that IN cord-015306-us58wwmp 4104 4 Persian persian JJ cord-015306-us58wwmp 4104 5 version version NN cord-015306-us58wwmp 4104 6 of of IN cord-015306-us58wwmp 4104 7 PedsQL PedsQL NNP cord-015306-us58wwmp 4104 8 TM TM NNP cord-015306-us58wwmp 4104 9 4.0TM 4.0tm CD cord-015306-us58wwmp 4104 10 4.0 4.0 CD cord-015306-us58wwmp 4104 11 Generic Generic NNP cord-015306-us58wwmp 4104 12 Core Core NNP cord-015306-us58wwmp 4104 13 Scales Scales NNP cord-015306-us58wwmp 4104 14 is be VBZ cord-015306-us58wwmp 4104 15 valid valid JJ cord-015306-us58wwmp 4104 16 and and CC cord-015306-us58wwmp 4104 17 acceptable acceptable JJ cord-015306-us58wwmp 4104 18 for for IN cord-015306-us58wwmp 4104 19 pediatric pediatric JJ cord-015306-us58wwmp 4104 20 health health NN cord-015306-us58wwmp 4104 21 researches research NNS cord-015306-us58wwmp 4104 22 . . . cord-015306-us58wwmp 4105 1 It -PRON- PRP cord-015306-us58wwmp 4105 2 is be VBZ cord-015306-us58wwmp 4105 3 necessary necessary JJ cord-015306-us58wwmp 4105 4 to to TO cord-015306-us58wwmp 4105 5 alternate alternate JJ cord-015306-us58wwmp 4105 6 scoring scoring NN cord-015306-us58wwmp 4105 7 for for IN cord-015306-us58wwmp 4105 8 2 2 CD cord-015306-us58wwmp 4105 9 - - SYM cord-015306-us58wwmp 4105 10 4 4 CD cord-015306-us58wwmp 4105 11 years year NNS cord-015306-us58wwmp 4105 12 old old JJ cord-015306-us58wwmp 4105 13 Objective objective NN cord-015306-us58wwmp 4105 14 : : : cord-015306-us58wwmp 4105 15 Bisphosphonates Bisphosphonates NNP cord-015306-us58wwmp 4105 16 are be VBP cord-015306-us58wwmp 4105 17 widely widely RB cord-015306-us58wwmp 4105 18 used use VBN cord-015306-us58wwmp 4105 19 in in IN cord-015306-us58wwmp 4105 20 the the DT cord-015306-us58wwmp 4105 21 management management NN cord-015306-us58wwmp 4105 22 of of IN cord-015306-us58wwmp 4105 23 children child NNS cord-015306-us58wwmp 4105 24 with with IN cord-015306-us58wwmp 4105 25 steroid steroid NN cord-015306-us58wwmp 4105 26 induced induce VBN cord-015306-us58wwmp 4105 27 osteoporosis osteoporosis NN cord-015306-us58wwmp 4105 28 ( ( -LRB- cord-015306-us58wwmp 4105 29 SIO SIO NNP cord-015306-us58wwmp 4105 30 ) ) -RRB- cord-015306-us58wwmp 4105 31 . . . cord-015306-us58wwmp 4106 1 With with IN cord-015306-us58wwmp 4106 2 the the DT cord-015306-us58wwmp 4106 3 increasing increase VBG cord-015306-us58wwmp 4106 4 use use NN cord-015306-us58wwmp 4106 5 of of IN cord-015306-us58wwmp 4106 6 bisphosphonates bisphosphonate NNS cord-015306-us58wwmp 4106 7 , , , cord-015306-us58wwmp 4106 8 there there EX cord-015306-us58wwmp 4106 9 have have VBP cord-015306-us58wwmp 4106 10 been be VBN cord-015306-us58wwmp 4106 11 reports report NNS cord-015306-us58wwmp 4106 12 of of IN cord-015306-us58wwmp 4106 13 abnormal abnormal JJ cord-015306-us58wwmp 4106 14 radiological radiological JJ cord-015306-us58wwmp 4106 15 findings finding NNS cord-015306-us58wwmp 4106 16 in in IN cord-015306-us58wwmp 4106 17 the the DT cord-015306-us58wwmp 4106 18 growing grow VBG cord-015306-us58wwmp 4106 19 skeleton skeleton NN cord-015306-us58wwmp 4106 20 . . . cord-015306-us58wwmp 4107 1 Therefore therefore RB cord-015306-us58wwmp 4107 2 , , , cord-015306-us58wwmp 4107 3 their -PRON- PRP$ cord-015306-us58wwmp 4107 4 use use NN cord-015306-us58wwmp 4107 5 in in IN cord-015306-us58wwmp 4107 6 pediatric pediatric JJ cord-015306-us58wwmp 4107 7 patients patient NNS cord-015306-us58wwmp 4107 8 remains remain VBZ cord-015306-us58wwmp 4107 9 controversial controversial JJ cord-015306-us58wwmp 4107 10 . . . cord-015306-us58wwmp 4108 1 The the DT cord-015306-us58wwmp 4108 2 present present JJ cord-015306-us58wwmp 4108 3 study study NN cord-015306-us58wwmp 4108 4 was be VBD cord-015306-us58wwmp 4108 5 conducted conduct VBN cord-015306-us58wwmp 4108 6 to to TO cord-015306-us58wwmp 4108 7 evaluate evaluate VB cord-015306-us58wwmp 4108 8 the the DT cord-015306-us58wwmp 4108 9 long long JJ cord-015306-us58wwmp 4108 10 term term NN cord-015306-us58wwmp 4108 11 follow follow NN cord-015306-us58wwmp 4108 12 - - HYPH cord-015306-us58wwmp 4108 13 up up RP cord-015306-us58wwmp 4108 14 results result NNS cord-015306-us58wwmp 4108 15 of of IN cord-015306-us58wwmp 4108 16 radiographic radiographic JJ cord-015306-us58wwmp 4108 17 features feature NNS cord-015306-us58wwmp 4108 18 especially especially RB cord-015306-us58wwmp 4108 19 metaphyseal metaphyseal VBP cord-015306-us58wwmp 4108 20 sclerotic sclerotic JJ cord-015306-us58wwmp 4108 21 lines line NNS cord-015306-us58wwmp 4108 22 , , , cord-015306-us58wwmp 4108 23 associated associate VBN cord-015306-us58wwmp 4108 24 with with IN cord-015306-us58wwmp 4108 25 pamidronate pamidronate JJ cord-015306-us58wwmp 4108 26 therapy therapy NN cord-015306-us58wwmp 4108 27 in in IN cord-015306-us58wwmp 4108 28 pediatric pediatric JJ cord-015306-us58wwmp 4108 29 patients patient NNS cord-015306-us58wwmp 4108 30 with with IN cord-015306-us58wwmp 4108 31 nephropathy nephropathy NN cord-015306-us58wwmp 4108 32 . . . cord-015306-us58wwmp 4109 1 Methods method NNS cord-015306-us58wwmp 4109 2 : : : cord-015306-us58wwmp 4110 1 Twenty twenty CD cord-015306-us58wwmp 4110 2 two two CD cord-015306-us58wwmp 4110 3 children child NNS cord-015306-us58wwmp 4110 4 with with IN cord-015306-us58wwmp 4110 5 nephropathy nephropathy NN cord-015306-us58wwmp 4110 6 receiving receive VBG cord-015306-us58wwmp 4110 7 oral oral JJ cord-015306-us58wwmp 4110 8 calcium calcium NN cord-015306-us58wwmp 4110 9 and and CC cord-015306-us58wwmp 4110 10 pamidronate pamidronate JJ cord-015306-us58wwmp 4110 11 ( ( -LRB- cord-015306-us58wwmp 4110 12 mean mean JJ cord-015306-us58wwmp 4110 13 duration duration NN cord-015306-us58wwmp 4110 14 : : : cord-015306-us58wwmp 4110 15 7.9 7.9 CD cord-015306-us58wwmp 4110 16 months month NNS cord-015306-us58wwmp 4110 17 , , , cord-015306-us58wwmp 4110 18 dose dose NN cord-015306-us58wwmp 4110 19 : : : cord-015306-us58wwmp 4111 1 125 125 CD cord-015306-us58wwmp 4111 2 mg mg NNP cord-015306-us58wwmp 4111 3 daily daily NN cord-015306-us58wwmp 4111 4 ) ) -RRB- cord-015306-us58wwmp 4111 5 were be VBD cord-015306-us58wwmp 4111 6 evaluated evaluate VBN cord-015306-us58wwmp 4111 7 restrospectively restrospectively RB cord-015306-us58wwmp 4111 8 . . . cord-015306-us58wwmp 4112 1 All all DT cord-015306-us58wwmp 4112 2 Patients patient NNS cord-015306-us58wwmp 4112 3 had have VBD cord-015306-us58wwmp 4112 4 SOI SOI NNP cord-015306-us58wwmp 4112 5 because because IN cord-015306-us58wwmp 4112 6 of of IN cord-015306-us58wwmp 4112 7 chronic chronic JJ cord-015306-us58wwmp 4112 8 glucocorticoid glucocorticoid NN cord-015306-us58wwmp 4112 9 therapy therapy NN cord-015306-us58wwmp 4112 10 for for IN cord-015306-us58wwmp 4112 11 the the DT cord-015306-us58wwmp 4112 12 treatment treatment NN cord-015306-us58wwmp 4112 13 of of IN cord-015306-us58wwmp 4112 14 nephropathy nephropathy NN cord-015306-us58wwmp 4112 15 . . . cord-015306-us58wwmp 4113 1 Biochemical biochemical JJ cord-015306-us58wwmp 4113 2 tests test NNS cord-015306-us58wwmp 4113 3 , , , cord-015306-us58wwmp 4113 4 long long JJ cord-015306-us58wwmp 4113 5 bone bone NN cord-015306-us58wwmp 4113 6 radiography radiography NN cord-015306-us58wwmp 4113 7 and and CC cord-015306-us58wwmp 4113 8 bone bone NN cord-015306-us58wwmp 4113 9 mineral mineral NN cord-015306-us58wwmp 4113 10 density density NN cord-015306-us58wwmp 4113 11 ( ( -LRB- cord-015306-us58wwmp 4113 12 BMD BMD NNP cord-015306-us58wwmp 4113 13 ) ) -RRB- cord-015306-us58wwmp 4113 14 were be VBD cord-015306-us58wwmp 4113 15 performed perform VBN cord-015306-us58wwmp 4113 16 before before IN cord-015306-us58wwmp 4113 17 the the DT cord-015306-us58wwmp 4113 18 treatment treatment NN cord-015306-us58wwmp 4113 19 of of IN cord-015306-us58wwmp 4113 20 pamidronate pamidronate NNP cord-015306-us58wwmp 4113 21 and and CC cord-015306-us58wwmp 4113 22 followed follow VBD cord-015306-us58wwmp 4113 23 up up RP cord-015306-us58wwmp 4113 24 several several JJ cord-015306-us58wwmp 4113 25 years year NNS cord-015306-us58wwmp 4113 26 later later RB cord-015306-us58wwmp 4113 27 . . . cord-015306-us58wwmp 4114 1 The the DT cord-015306-us58wwmp 4114 2 physeal physeal JJ cord-015306-us58wwmp 4114 3 growth growth NN cord-015306-us58wwmp 4114 4 rates rate NNS cord-015306-us58wwmp 4114 5 were be VBD cord-015306-us58wwmp 4114 6 estimated estimate VBN cord-015306-us58wwmp 4114 7 by by IN cord-015306-us58wwmp 4114 8 measuring measure VBG cord-015306-us58wwmp 4114 9 the the DT cord-015306-us58wwmp 4114 10 distance distance NN cord-015306-us58wwmp 4114 11 that that IN cord-015306-us58wwmp 4114 12 the the DT cord-015306-us58wwmp 4114 13 sclerotic sclerotic JJ cord-015306-us58wwmp 4114 14 lines line NNS cord-015306-us58wwmp 4114 15 moved move VBD cord-015306-us58wwmp 4114 16 on on IN cord-015306-us58wwmp 4114 17 the the DT cord-015306-us58wwmp 4114 18 radiographs radiograph NNS cord-015306-us58wwmp 4114 19 during during IN cord-015306-us58wwmp 4114 20 the the DT cord-015306-us58wwmp 4114 21 corresponding corresponding JJ cord-015306-us58wwmp 4114 22 time time NN cord-015306-us58wwmp 4114 23 intervals interval NNS cord-015306-us58wwmp 4114 24 . . . cord-015306-us58wwmp 4115 1 Results result NNS cord-015306-us58wwmp 4115 2 : : : cord-015306-us58wwmp 4116 1 The the DT cord-015306-us58wwmp 4116 2 mean mean JJ cord-015306-us58wwmp 4116 3 follow follow NN cord-015306-us58wwmp 4116 4 - - HYPH cord-015306-us58wwmp 4116 5 up up NN cord-015306-us58wwmp 4116 6 period period NN cord-015306-us58wwmp 4116 7 was be VBD cord-015306-us58wwmp 4116 8 9.5 9.5 CD cord-015306-us58wwmp 4116 9 years year NNS cord-015306-us58wwmp 4116 10 . . . cord-015306-us58wwmp 4117 1 In in IN cord-015306-us58wwmp 4117 2 all all DT cord-015306-us58wwmp 4117 3 patients patient NNS cord-015306-us58wwmp 4117 4 , , , cord-015306-us58wwmp 4117 5 the the DT cord-015306-us58wwmp 4117 6 well well RB cord-015306-us58wwmp 4117 7 - - HYPH cord-015306-us58wwmp 4117 8 defined define VBN cord-015306-us58wwmp 4117 9 sclerotic sclerotic JJ cord-015306-us58wwmp 4117 10 lines line NNS cord-015306-us58wwmp 4117 11 at at IN cord-015306-us58wwmp 4117 12 the the DT cord-015306-us58wwmp 4117 13 metaphyseal metaphyseal NN cord-015306-us58wwmp 4117 14 ends end NNS cord-015306-us58wwmp 4117 15 were be VBD cord-015306-us58wwmp 4117 16 observed observe VBN cord-015306-us58wwmp 4117 17 and and CC cord-015306-us58wwmp 4117 18 progressively progressively RB cord-015306-us58wwmp 4117 19 moved move VBN cord-015306-us58wwmp 4117 20 from from IN cord-015306-us58wwmp 4117 21 physeal physeal JJ cord-015306-us58wwmp 4117 22 plate plate NN cord-015306-us58wwmp 4117 23 to to IN cord-015306-us58wwmp 4117 24 diaphysis diaphysis NN cord-015306-us58wwmp 4117 25 on on IN cord-015306-us58wwmp 4117 26 the the DT cord-015306-us58wwmp 4117 27 radiographs radiograph NNS cord-015306-us58wwmp 4117 28 of of IN cord-015306-us58wwmp 4117 29 long long JJ cord-015306-us58wwmp 4117 30 bones bone NNS cord-015306-us58wwmp 4117 31 . . . cord-015306-us58wwmp 4118 1 The the DT cord-015306-us58wwmp 4118 2 mean mean NN cord-015306-us58wwmp 4118 3 moving move VBG cord-015306-us58wwmp 4118 4 rates rate NNS cord-015306-us58wwmp 4118 5 of of IN cord-015306-us58wwmp 4118 6 the the DT cord-015306-us58wwmp 4118 7 sclerotic sclerotic JJ cord-015306-us58wwmp 4118 8 lines line NNS cord-015306-us58wwmp 4118 9 was be VBD cord-015306-us58wwmp 4118 10 7.95 7.95 CD cord-015306-us58wwmp 4118 11 mm mm NN cord-015306-us58wwmp 4118 12 per per IN cord-015306-us58wwmp 4118 13 year year NN cord-015306-us58wwmp 4118 14 and and CC cord-015306-us58wwmp 4118 15 in in IN cord-015306-us58wwmp 4118 16 twelve twelve CD cord-015306-us58wwmp 4118 17 patients patient NNS cord-015306-us58wwmp 4118 18 , , , cord-015306-us58wwmp 4118 19 the the DT cord-015306-us58wwmp 4118 20 lines line NNS cord-015306-us58wwmp 4118 21 disappeared disappear VBD cord-015306-us58wwmp 4118 22 . . . cord-015306-us58wwmp 4119 1 And and CC cord-015306-us58wwmp 4119 2 the the DT cord-015306-us58wwmp 4119 3 mean mean JJ cord-015306-us58wwmp 4119 4 growth growth NN cord-015306-us58wwmp 4119 5 rate rate NN cord-015306-us58wwmp 4119 6 of of IN cord-015306-us58wwmp 4119 7 height height NN cord-015306-us58wwmp 4119 8 was be VBD cord-015306-us58wwmp 4119 9 4.50 4.50 CD cord-015306-us58wwmp 4119 10 cm cm NNS cord-015306-us58wwmp 4119 11 per per IN cord-015306-us58wwmp 4119 12 year year NN cord-015306-us58wwmp 4119 13 . . . cord-015306-us58wwmp 4120 1 Conclusion conclusion NN cord-015306-us58wwmp 4120 2 : : : cord-015306-us58wwmp 4121 1 Our -PRON- PRP$ cord-015306-us58wwmp 4121 2 long long JJ cord-015306-us58wwmp 4121 3 - - HYPH cord-015306-us58wwmp 4121 4 term term NN cord-015306-us58wwmp 4121 5 follow follow NN cord-015306-us58wwmp 4121 6 - - HYPH cord-015306-us58wwmp 4121 7 up up NN cord-015306-us58wwmp 4121 8 results result NNS cord-015306-us58wwmp 4121 9 suggest suggest VBP cord-015306-us58wwmp 4121 10 that that IN cord-015306-us58wwmp 4121 11 the the DT cord-015306-us58wwmp 4121 12 metaphyseal metaphyseal JJ cord-015306-us58wwmp 4121 13 sclerotic sclerotic JJ cord-015306-us58wwmp 4121 14 lines line NNS cord-015306-us58wwmp 4121 15 associated associate VBN cord-015306-us58wwmp 4121 16 with with IN cord-015306-us58wwmp 4121 17 pamidronate pamidronate JJ cord-015306-us58wwmp 4121 18 treatment treatment NN cord-015306-us58wwmp 4121 19 tend tend VBP cord-015306-us58wwmp 4121 20 to to TO cord-015306-us58wwmp 4121 21 disappear disappear VB cord-015306-us58wwmp 4121 22 without without IN cord-015306-us58wwmp 4121 23 affecting affect VBG cord-015306-us58wwmp 4121 24 the the DT cord-015306-us58wwmp 4121 25 skeletal skeletal JJ cord-015306-us58wwmp 4121 26 growth growth NN cord-015306-us58wwmp 4121 27 . . . cord-015306-us58wwmp 4122 1 Bisphosphonate Bisphosphonate NNP cord-015306-us58wwmp 4122 2 treatment treatment NN cord-015306-us58wwmp 4122 3 for for IN cord-015306-us58wwmp 4122 4 SOI SOI NNP cord-015306-us58wwmp 4122 5 in in IN cord-015306-us58wwmp 4122 6 pediatric pediatric JJ cord-015306-us58wwmp 4122 7 patients patient NNS cord-015306-us58wwmp 4122 8 with with IN cord-015306-us58wwmp 4122 9 nephropathy nephropathy NN cord-015306-us58wwmp 4122 10 seems seem VBZ cord-015306-us58wwmp 4122 11 to to TO cord-015306-us58wwmp 4122 12 be be VB cord-015306-us58wwmp 4122 13 safe safe JJ cord-015306-us58wwmp 4122 14 although although IN cord-015306-us58wwmp 4122 15 further further JJ cord-015306-us58wwmp 4122 16 studies study NNS cord-015306-us58wwmp 4122 17 for for IN cord-015306-us58wwmp 4122 18 larger large JJR cord-015306-us58wwmp 4122 19 number number NN cord-015306-us58wwmp 4122 20 of of IN cord-015306-us58wwmp 4122 21 patients patient NNS cord-015306-us58wwmp 4122 22 are be VBP cord-015306-us58wwmp 4122 23 needed need VBN cord-015306-us58wwmp 4122 24 Abstract Abstract NNP cord-015306-us58wwmp 4122 25 # # NN cord-015306-us58wwmp 4122 26 P p NN cord-015306-us58wwmp 4122 27 - - : cord-015306-us58wwmp 4122 28 SAT366 SAT366 NNP cord-015306-us58wwmp 4122 29 Clinical clinical JJ cord-015306-us58wwmp 4122 30 effectiveness effectiveness NN cord-015306-us58wwmp 4122 31 and and CC cord-015306-us58wwmp 4122 32 safety safety NN cord-015306-us58wwmp 4122 33 of of IN cord-015306-us58wwmp 4122 34 the the DT cord-015306-us58wwmp 4122 35 high high JJ cord-015306-us58wwmp 4122 36 dose dose NN cord-015306-us58wwmp 4122 37 active active JJ cord-015306-us58wwmp 4122 38 vitamin vitamin NN cord-015306-us58wwmp 4122 39 D d NN cord-015306-us58wwmp 4122 40 therapy therapy NN cord-015306-us58wwmp 4122 41 on on IN cord-015306-us58wwmp 4122 42 severe severe JJ cord-015306-us58wwmp 4122 43 hyperparathyroidism hyperparathyroidism NN cord-015306-us58wwmp 4122 44 in in IN cord-015306-us58wwmp 4122 45 children child NNS cord-015306-us58wwmp 4122 46 with with IN cord-015306-us58wwmp 4122 47 ESRD ESRD NNP cord-015306-us58wwmp 4122 48 Eun Eun NNP cord-015306-us58wwmp 4122 49 Gu Gu NNP cord-015306-us58wwmp 4122 50 Kang Kang NNP cord-015306-us58wwmp 4122 51 , , , cord-015306-us58wwmp 4122 52 Su Su NNP cord-015306-us58wwmp 4122 53 - - HYPH cord-015306-us58wwmp 4122 54 Yon Yon NNP cord-015306-us58wwmp 4122 55 Kim Kim NNP cord-015306-us58wwmp 4122 56 , , , cord-015306-us58wwmp 4122 57 Joo Joo NNP cord-015306-us58wwmp 4122 58 Hoon Hoon NNP cord-015306-us58wwmp 4122 59 Lee Lee NNP cord-015306-us58wwmp 4122 60 , , , cord-015306-us58wwmp 4122 61 Young Young NNP cord-015306-us58wwmp 4122 62 Seo Seo NNP cord-015306-us58wwmp 4122 63 Park Park NNP cord-015306-us58wwmp 4122 64 Department Department NNP cord-015306-us58wwmp 4122 65 of of IN cord-015306-us58wwmp 4122 66 Pediatrics Pediatrics NNP cord-015306-us58wwmp 4122 67 , , , cord-015306-us58wwmp 4122 68 Asan Asan NNP cord-015306-us58wwmp 4122 69 Medical Medical NNP cord-015306-us58wwmp 4122 70 Center Center NNP cord-015306-us58wwmp 4122 71 Children Children NNPS cord-015306-us58wwmp 4122 72 's 's POS cord-015306-us58wwmp 4122 73 Hospital Hospital NNP cord-015306-us58wwmp 4122 74 , , , cord-015306-us58wwmp 4122 75 Seoul Seoul NNP cord-015306-us58wwmp 4122 76 , , , cord-015306-us58wwmp 4122 77 Korea Korea NNP cord-015306-us58wwmp 4122 78 Objective Objective NNP cord-015306-us58wwmp 4122 79 : : : cord-015306-us58wwmp 4122 80 A a DT cord-015306-us58wwmp 4122 81 potent potent JJ cord-015306-us58wwmp 4122 82 inhibiting inhibit VBG cord-015306-us58wwmp 4122 83 effect effect NN cord-015306-us58wwmp 4122 84 of of IN cord-015306-us58wwmp 4122 85 active active JJ cord-015306-us58wwmp 4122 86 vitamin vitamin NN cord-015306-us58wwmp 4122 87 D d NN cord-015306-us58wwmp 4122 88 on on IN cord-015306-us58wwmp 4122 89 parathyroid parathyroid JJ cord-015306-us58wwmp 4122 90 hormone hormone NN cord-015306-us58wwmp 4122 91 is be VBZ cord-015306-us58wwmp 4122 92 well well RB cord-015306-us58wwmp 4122 93 known known JJ cord-015306-us58wwmp 4122 94 , , , cord-015306-us58wwmp 4122 95 but but CC cord-015306-us58wwmp 4122 96 there there EX cord-015306-us58wwmp 4122 97 is be VBZ cord-015306-us58wwmp 4122 98 uncertainty uncertainty NN cord-015306-us58wwmp 4122 99 on on IN cord-015306-us58wwmp 4122 100 the the DT cord-015306-us58wwmp 4122 101 dose dose NN cord-015306-us58wwmp 4122 102 to to TO cord-015306-us58wwmp 4122 103 be be VB cord-015306-us58wwmp 4122 104 used use VBN cord-015306-us58wwmp 4122 105 in in IN cord-015306-us58wwmp 4122 106 hyperparathyroidism hyperparathyroidism NN cord-015306-us58wwmp 4122 107 . . . cord-015306-us58wwmp 4123 1 The the DT cord-015306-us58wwmp 4123 2 aim aim NN cord-015306-us58wwmp 4123 3 of of IN cord-015306-us58wwmp 4123 4 this this DT cord-015306-us58wwmp 4123 5 study study NN cord-015306-us58wwmp 4123 6 is be VBZ cord-015306-us58wwmp 4123 7 to to TO cord-015306-us58wwmp 4123 8 assess assess VB cord-015306-us58wwmp 4123 9 the the DT cord-015306-us58wwmp 4123 10 effectiveness effectiveness NN cord-015306-us58wwmp 4123 11 and and CC cord-015306-us58wwmp 4123 12 safety safety NN cord-015306-us58wwmp 4123 13 of of IN cord-015306-us58wwmp 4123 14 high high JJ cord-015306-us58wwmp 4123 15 dose dose NN cord-015306-us58wwmp 4123 16 active active JJ cord-015306-us58wwmp 4123 17 vitamin vitamin NN cord-015306-us58wwmp 4123 18 D d NN cord-015306-us58wwmp 4123 19 treatment treatment NN cord-015306-us58wwmp 4123 20 on on IN cord-015306-us58wwmp 4123 21 severe severe JJ cord-015306-us58wwmp 4123 22 hyperparathyroidism hyperparathyroidism NN cord-015306-us58wwmp 4123 23 in in IN cord-015306-us58wwmp 4123 24 children child NNS cord-015306-us58wwmp 4123 25 with with IN cord-015306-us58wwmp 4123 26 end end NN cord-015306-us58wwmp 4123 27 stage stage NN cord-015306-us58wwmp 4123 28 renal renal JJ cord-015306-us58wwmp 4123 29 disease disease NN cord-015306-us58wwmp 4123 30 ( ( -LRB- cord-015306-us58wwmp 4123 31 ESRD ESRD NNP cord-015306-us58wwmp 4123 32 ) ) -RRB- cord-015306-us58wwmp 4123 33 . . . cord-015306-us58wwmp 4124 1 Methods method NNS cord-015306-us58wwmp 4124 2 : : : cord-015306-us58wwmp 4124 3 Fifty fifty CD cord-015306-us58wwmp 4124 4 - - HYPH cord-015306-us58wwmp 4124 5 four four CD cord-015306-us58wwmp 4124 6 patients patient NNS cord-015306-us58wwmp 4124 7 underwent undergo VBD cord-015306-us58wwmp 4124 8 dialysis dialysis NN cord-015306-us58wwmp 4124 9 for for IN cord-015306-us58wwmp 4124 10 more more JJR cord-015306-us58wwmp 4124 11 than than IN cord-015306-us58wwmp 4124 12 1 1 CD cord-015306-us58wwmp 4124 13 year year NN cord-015306-us58wwmp 4124 14 between between IN cord-015306-us58wwmp 4124 15 May May NNP cord-015306-us58wwmp 4124 16 2002 2002 CD cord-015306-us58wwmp 4124 17 and and CC cord-015306-us58wwmp 4124 18 Feb Feb NNP cord-015306-us58wwmp 4124 19 2013 2013 CD cord-015306-us58wwmp 4124 20 in in IN cord-015306-us58wwmp 4124 21 Asan Asan NNP cord-015306-us58wwmp 4124 22 Medical Medical NNP cord-015306-us58wwmp 4124 23 Center Center NNP cord-015306-us58wwmp 4124 24 . . . cord-015306-us58wwmp 4125 1 Among among IN cord-015306-us58wwmp 4125 2 them -PRON- PRP cord-015306-us58wwmp 4125 3 , , , cord-015306-us58wwmp 4125 4 patients patient NNS cord-015306-us58wwmp 4125 5 who who WP cord-015306-us58wwmp 4125 6 were be VBD cord-015306-us58wwmp 4125 7 administered administer VBN cord-015306-us58wwmp 4125 8 high high JJ cord-015306-us58wwmp 4125 9 dose dose NN cord-015306-us58wwmp 4125 10 of of IN cord-015306-us58wwmp 4125 11 active active JJ cord-015306-us58wwmp 4125 12 vitamin vitamin NN cord-015306-us58wwmp 4125 13 D d NN cord-015306-us58wwmp 4125 14 ( ( -LRB- cord-015306-us58wwmp 4125 15 dose dose NN cord-015306-us58wwmp 4125 16 of of IN cord-015306-us58wwmp 4125 17 alfacalcidol alfacalcidol NNP cord-015306-us58wwmp 4125 18 1mcg 1mcg CD cord-015306-us58wwmp 4125 19 / / SYM cord-015306-us58wwmp 4125 20 day day NN cord-015306-us58wwmp 4125 21 to to IN cord-015306-us58wwmp 4125 22 3mcg 3mcg CD cord-015306-us58wwmp 4125 23 / / SYM cord-015306-us58wwmp 4125 24 day day NN cord-015306-us58wwmp 4125 25 ) ) -RRB- cord-015306-us58wwmp 4125 26 with with IN cord-015306-us58wwmp 4125 27 severe severe JJ cord-015306-us58wwmp 4125 28 hyperparathyroidism(intact hyperparathyroidism(intact NNP cord-015306-us58wwmp 4125 29 parathyroid parathyroid JJ cord-015306-us58wwmp 4125 30 hormone hormone NN cord-015306-us58wwmp 4125 31 ( ( -LRB- cord-015306-us58wwmp 4125 32 iPTH iPTH NNP cord-015306-us58wwmp 4125 33 ) ) -RRB- cord-015306-us58wwmp 4126 1 > > XX cord-015306-us58wwmp 4127 1 800pg 800pg NNP cord-015306-us58wwmp 4127 2 / / SYM cord-015306-us58wwmp 4127 3 mL mL NNP cord-015306-us58wwmp 4127 4 ) ) -RRB- cord-015306-us58wwmp 4127 5 were be VBD cord-015306-us58wwmp 4127 6 selected select VBN cord-015306-us58wwmp 4127 7 . . . cord-015306-us58wwmp 4128 1 Changes change NNS cord-015306-us58wwmp 4128 2 of of IN cord-015306-us58wwmp 4128 3 iPTH ipth JJ cord-015306-us58wwmp 4128 4 , , , cord-015306-us58wwmp 4128 5 plasma plasma NN cord-015306-us58wwmp 4128 6 albumin albumin NN cord-015306-us58wwmp 4128 7 - - HYPH cord-015306-us58wwmp 4128 8 corrected correct VBN cord-015306-us58wwmp 4128 9 calcium calcium NN cord-015306-us58wwmp 4128 10 , , , cord-015306-us58wwmp 4128 11 phosphorus phosphorus NN cord-015306-us58wwmp 4128 12 and and CC cord-015306-us58wwmp 4128 13 1,25 1,25 CD cord-015306-us58wwmp 4128 14 ( ( -LRB- cord-015306-us58wwmp 4128 15 OH)2 oh)2 JJ cord-015306-us58wwmp 4128 16 vitamin vitamin NN cord-015306-us58wwmp 4128 17 D D NNS cord-015306-us58wwmp 4128 18 were be VBD cord-015306-us58wwmp 4128 19 analysed analyse VBN cord-015306-us58wwmp 4128 20 . . . cord-015306-us58wwmp 4129 1 Results result NNS cord-015306-us58wwmp 4129 2 : : : cord-015306-us58wwmp 4130 1 Fourteen fourteen CD cord-015306-us58wwmp 4130 2 patients patient NNS cord-015306-us58wwmp 4130 3 ( ( -LRB- cord-015306-us58wwmp 4130 4 10 10 CD cord-015306-us58wwmp 4130 5 boys boy NNS cord-015306-us58wwmp 4130 6 and and CC cord-015306-us58wwmp 4130 7 4 4 CD cord-015306-us58wwmp 4130 8 girls girl NNS cord-015306-us58wwmp 4130 9 ) ) -RRB- cord-015306-us58wwmp 4130 10 with with IN cord-015306-us58wwmp 4130 11 median median JJ cord-015306-us58wwmp 4130 12 age age NN cord-015306-us58wwmp 4130 13 of of IN cord-015306-us58wwmp 4130 14 12.5 12.5 CD cord-015306-us58wwmp 4130 15 years year NNS cord-015306-us58wwmp 4130 16 ( ( -LRB- cord-015306-us58wwmp 4130 17 6 6 CD cord-015306-us58wwmp 4130 18 - - SYM cord-015306-us58wwmp 4130 19 19 19 CD cord-015306-us58wwmp 4130 20 years year NNS cord-015306-us58wwmp 4130 21 ) ) -RRB- cord-015306-us58wwmp 4130 22 were be VBD cord-015306-us58wwmp 4130 23 included include VBN cord-015306-us58wwmp 4130 24 . . . cord-015306-us58wwmp 4131 1 The the DT cord-015306-us58wwmp 4131 2 mean mean JJ cord-015306-us58wwmp 4131 3 duration duration NN cord-015306-us58wwmp 4131 4 of of IN cord-015306-us58wwmp 4131 5 dialysis dialysis NN cord-015306-us58wwmp 4131 6 was be VBD cord-015306-us58wwmp 4131 7 49±32 49±32 CD cord-015306-us58wwmp 4131 8 months month NNS cord-015306-us58wwmp 4131 9 and and CC cord-015306-us58wwmp 4132 1 the the DT cord-015306-us58wwmp 4132 2 median median JJ cord-015306-us58wwmp 4132 3 duration duration NN cord-015306-us58wwmp 4132 4 of of IN cord-015306-us58wwmp 4132 5 the the DT cord-015306-us58wwmp 4132 6 high high JJ cord-015306-us58wwmp 4132 7 dose dose NN cord-015306-us58wwmp 4132 8 alfacalcidol alfacalcidol NN cord-015306-us58wwmp 4132 9 therapy therapy NN cord-015306-us58wwmp 4132 10 was be VBD cord-015306-us58wwmp 4132 11 5 5 CD cord-015306-us58wwmp 4132 12 months(3 months(3 JJR cord-015306-us58wwmp 4132 13 - - HYPH cord-015306-us58wwmp 4132 14 22months 22months CD cord-015306-us58wwmp 4132 15 ) ) -RRB- cord-015306-us58wwmp 4132 16 . . . cord-015306-us58wwmp 4133 1 The the DT cord-015306-us58wwmp 4133 2 iPTH ipth JJ cord-015306-us58wwmp 4133 3 level level NN cord-015306-us58wwmp 4133 4 significantly significantly RB cord-015306-us58wwmp 4133 5 decreased decrease VBD cord-015306-us58wwmp 4133 6 in in IN cord-015306-us58wwmp 4133 7 10 10 CD cord-015306-us58wwmp 4133 8 patients patient NNS cord-015306-us58wwmp 4133 9 ( ( -LRB- cord-015306-us58wwmp 4133 10 71 71 CD cord-015306-us58wwmp 4133 11 % % NN cord-015306-us58wwmp 4133 12 ) ) -RRB- cord-015306-us58wwmp 4133 13 from from IN cord-015306-us58wwmp 4133 14 1206.3±387.6 1206.3±387.6 CD cord-015306-us58wwmp 4133 15 to to IN cord-015306-us58wwmp 4133 16 215.2±117 215.2±117 CD cord-015306-us58wwmp 4133 17 during during IN cord-015306-us58wwmp 4133 18 the the DT cord-015306-us58wwmp 4133 19 high high JJ cord-015306-us58wwmp 4133 20 dose dose NN cord-015306-us58wwmp 4133 21 alfacalcidol alfacalcidol NN cord-015306-us58wwmp 4133 22 therapy therapy NN cord-015306-us58wwmp 4133 23 ( ( -LRB- cord-015306-us58wwmp 4133 24 p<0.001 p<0.001 CD cord-015306-us58wwmp 4133 25 ) ) -RRB- cord-015306-us58wwmp 4133 26 . . . cord-015306-us58wwmp 4134 1 Serum serum NN cord-015306-us58wwmp 4134 2 phosphorus phosphorus NN cord-015306-us58wwmp 4134 3 ( ( -LRB- cord-015306-us58wwmp 4134 4 5.9±1.3mg 5.9±1.3mg CD cord-015306-us58wwmp 4134 5 / / SYM cord-015306-us58wwmp 4134 6 dL dl NN cord-015306-us58wwmp 4134 7 vs. vs. FW cord-015306-us58wwmp 4134 8 6.0±1.8mg 6.0±1.8mg CD cord-015306-us58wwmp 4134 9 / / SYM cord-015306-us58wwmp 4134 10 dL dl NN cord-015306-us58wwmp 4134 11 , , , cord-015306-us58wwmp 4134 12 p=0.88 p=0.88 NNP cord-015306-us58wwmp 4134 13 ) ) -RRB- cord-015306-us58wwmp 4134 14 and and CC cord-015306-us58wwmp 4134 15 calciumphosphorus calciumphosphorus NNP cord-015306-us58wwmp 4134 16 product product NN cord-015306-us58wwmp 4134 17 ( ( -LRB- cord-015306-us58wwmp 4134 18 53.4±11.9mg2 53.4±11.9mg2 NNP cord-015306-us58wwmp 4134 19 / / SYM cord-015306-us58wwmp 4134 20 dL2 dl2 FW cord-015306-us58wwmp 4134 21 vs. vs. FW cord-015306-us58wwmp 4134 22 59.8±18.4mg2 59.8±18.4mg2 NNP cord-015306-us58wwmp 4135 1 /dL2 /dL2 NFP cord-015306-us58wwmp 4135 2 , , , cord-015306-us58wwmp 4135 3 p=0.20 p=0.20 NN cord-015306-us58wwmp 4135 4 ) ) -RRB- cord-015306-us58wwmp 4135 5 were be VBD cord-015306-us58wwmp 4135 6 not not RB cord-015306-us58wwmp 4135 7 significantly significantly RB cord-015306-us58wwmp 4135 8 changed change VBN cord-015306-us58wwmp 4135 9 and and CC cord-015306-us58wwmp 4135 10 1,25 1,25 CD cord-015306-us58wwmp 4136 1 ( ( -LRB- cord-015306-us58wwmp 4136 2 OH)2 oh)2 JJ cord-015306-us58wwmp 4136 3 vitamin vitamin NN cord-015306-us58wwmp 4136 4 D d NN cord-015306-us58wwmp 4136 5 was be VBD cord-015306-us58wwmp 4136 6 low low JJ cord-015306-us58wwmp 4136 7 or or CC cord-015306-us58wwmp 4136 8 normal normal JJ cord-015306-us58wwmp 4136 9 after after IN cord-015306-us58wwmp 4136 10 therapy therapy NN cord-015306-us58wwmp 4136 11 . . . cord-015306-us58wwmp 4137 1 Plasma plasma NN cord-015306-us58wwmp 4137 2 albumin albumin NN cord-015306-us58wwmp 4137 3 - - HYPH cord-015306-us58wwmp 4137 4 corrected correct VBN cord-015306-us58wwmp 4137 5 calcium calcium NN cord-015306-us58wwmp 4137 6 significantly significantly RB cord-015306-us58wwmp 4137 7 increased increase VBD cord-015306-us58wwmp 4137 8 ( ( -LRB- cord-015306-us58wwmp 4137 9 9.4±0.64mg 9.4±0.64mg NNP cord-015306-us58wwmp 4137 10 / / SYM cord-015306-us58wwmp 4137 11 dL dl NN cord-015306-us58wwmp 4138 1 vs. vs. FW cord-015306-us58wwmp 4138 2 10.2±0.75mg 10.2±0.75mg CD cord-015306-us58wwmp 4138 3 / / SYM cord-015306-us58wwmp 4138 4 dL dl NN cord-015306-us58wwmp 4138 5 , , , cord-015306-us58wwmp 4138 6 p=0.016 p=0.016 RB cord-015306-us58wwmp 4138 7 ) ) -RRB- cord-015306-us58wwmp 4138 8 . . . cord-015306-us58wwmp 4139 1 Four four CD cord-015306-us58wwmp 4139 2 patients patient NNS cord-015306-us58wwmp 4139 3 ( ( -LRB- cord-015306-us58wwmp 4139 4 29 29 CD cord-015306-us58wwmp 4139 5 % % NN cord-015306-us58wwmp 4139 6 ) ) -RRB- cord-015306-us58wwmp 4139 7 had have VBD cord-015306-us58wwmp 4139 8 persistent persistent JJ cord-015306-us58wwmp 4139 9 severe severe JJ cord-015306-us58wwmp 4139 10 hyperparathyroidism hyperparathyroidism NN cord-015306-us58wwmp 4139 11 despite despite IN cord-015306-us58wwmp 4139 12 treatment treatment NN cord-015306-us58wwmp 4139 13 with with IN cord-015306-us58wwmp 4139 14 high high JJ cord-015306-us58wwmp 4139 15 dose dose NN cord-015306-us58wwmp 4139 16 of of IN cord-015306-us58wwmp 4139 17 alfacalcidol alfacalcidol NN cord-015306-us58wwmp 4139 18 , , , cord-015306-us58wwmp 4139 19 which which WDT cord-015306-us58wwmp 4139 20 was be VBD cord-015306-us58wwmp 4139 21 controlled control VBN cord-015306-us58wwmp 4139 22 after after IN cord-015306-us58wwmp 4139 23 kidney kidney NN cord-015306-us58wwmp 4139 24 transplantation transplantation NN cord-015306-us58wwmp 4139 25 ( ( -LRB- cord-015306-us58wwmp 4139 26 2 2 CD cord-015306-us58wwmp 4139 27 patients patient NNS cord-015306-us58wwmp 4139 28 ) ) -RRB- cord-015306-us58wwmp 4139 29 or or CC cord-015306-us58wwmp 4139 30 after after IN cord-015306-us58wwmp 4139 31 parathyroidectomy parathyroidectomy NN cord-015306-us58wwmp 4139 32 ( ( -LRB- cord-015306-us58wwmp 4139 33 2 2 CD cord-015306-us58wwmp 4139 34 patients).Conclusion patients).conclusion NN cord-015306-us58wwmp 4139 35 : : : cord-015306-us58wwmp 4139 36 High high JJ cord-015306-us58wwmp 4139 37 dose dose NN cord-015306-us58wwmp 4139 38 active active JJ cord-015306-us58wwmp 4139 39 vitamin vitamin NN cord-015306-us58wwmp 4139 40 D d NN cord-015306-us58wwmp 4139 41 therapy therapy NN cord-015306-us58wwmp 4139 42 controlled control VBN cord-015306-us58wwmp 4139 43 severe severe JJ cord-015306-us58wwmp 4139 44 hyperparathyroidism hyperparathyroidism NN cord-015306-us58wwmp 4139 45 in in IN cord-015306-us58wwmp 4139 46 the the DT cord-015306-us58wwmp 4139 47 most most JJS cord-015306-us58wwmp 4139 48 children child NNS cord-015306-us58wwmp 4139 49 with with IN cord-015306-us58wwmp 4139 50 ESRD ESRD NNP cord-015306-us58wwmp 4139 51 without without IN cord-015306-us58wwmp 4139 52 significant significant JJ cord-015306-us58wwmp 4139 53 adverse adverse JJ cord-015306-us58wwmp 4139 54 events event NNS cord-015306-us58wwmp 4139 55 . . . cord-015306-us58wwmp 4140 1 Clinical clinical JJ cord-015306-us58wwmp 4140 2 features feature NNS cord-015306-us58wwmp 4140 3 and and CC cord-015306-us58wwmp 4140 4 treatment treatment NN cord-015306-us58wwmp 4140 5 of of IN cord-015306-us58wwmp 4140 6 CKD CKD NNP cord-015306-us58wwmp 4140 7 - - HYPH cord-015306-us58wwmp 4140 8 MBD MBD NNP cord-015306-us58wwmp 4140 9 in in IN cord-015306-us58wwmp 4140 10 children child NNS cord-015306-us58wwmp 4140 11 with with IN cord-015306-us58wwmp 4141 1 CKD CKD NNP cord-015306-us58wwmp 4141 2 I I NNP cord-015306-us58wwmp 4141 3 - - HYPH cord-015306-us58wwmp 4141 4 V V NNP cord-015306-us58wwmp 4141 5 predialysis predialysis NN cord-015306-us58wwmp 4141 6 Objective objective NN cord-015306-us58wwmp 4141 7 : : : cord-015306-us58wwmp 4142 1 Vitamin vitamin NN cord-015306-us58wwmp 4142 2 D d NN cord-015306-us58wwmp 4142 3 is be VBZ cord-015306-us58wwmp 4142 4 known know VBN cord-015306-us58wwmp 4142 5 to to TO cord-015306-us58wwmp 4142 6 have have VB cord-015306-us58wwmp 4142 7 multiple multiple JJ cord-015306-us58wwmp 4142 8 effects effect NNS cord-015306-us58wwmp 4142 9 on on IN cord-015306-us58wwmp 4142 10 the the DT cord-015306-us58wwmp 4142 11 cardiovascular cardiovascular JJ cord-015306-us58wwmp 4142 12 system system NN cord-015306-us58wwmp 4142 13 , , , cord-015306-us58wwmp 4142 14 renal renal JJ cord-015306-us58wwmp 4142 15 function function NN cord-015306-us58wwmp 4142 16 , , , cord-015306-us58wwmp 4142 17 hyperparathyroidism hyperparathyroidism NN cord-015306-us58wwmp 4142 18 and and CC cord-015306-us58wwmp 4142 19 growth growth NN cord-015306-us58wwmp 4142 20 , , , cord-015306-us58wwmp 4142 21 its -PRON- PRP$ cord-015306-us58wwmp 4142 22 deficiency deficiency NN cord-015306-us58wwmp 4142 23 is be VBZ cord-015306-us58wwmp 4142 24 common common JJ cord-015306-us58wwmp 4142 25 in in IN cord-015306-us58wwmp 4142 26 adults adult NNS cord-015306-us58wwmp 4142 27 and and CC cord-015306-us58wwmp 4142 28 children child NNS cord-015306-us58wwmp 4142 29 with with IN cord-015306-us58wwmp 4142 30 chronic chronic JJ cord-015306-us58wwmp 4142 31 renal renal JJ cord-015306-us58wwmp 4142 32 disease disease NN cord-015306-us58wwmp 4142 33 ( ( -LRB- cord-015306-us58wwmp 4142 34 CKD CKD NNP cord-015306-us58wwmp 4142 35 ) ) -RRB- cord-015306-us58wwmp 4142 36 , , , cord-015306-us58wwmp 4142 37 but but CC cord-015306-us58wwmp 4142 38 data datum NNS cord-015306-us58wwmp 4142 39 in in IN cord-015306-us58wwmp 4142 40 kidney kidney NN cord-015306-us58wwmp 4142 41 transplant transplant NN cord-015306-us58wwmp 4142 42 children child NNS cord-015306-us58wwmp 4142 43 are be VBP cord-015306-us58wwmp 4142 44 scarce scarce JJ cord-015306-us58wwmp 4142 45 . . . cord-015306-us58wwmp 4143 1 The the DT cord-015306-us58wwmp 4143 2 aim aim NN cord-015306-us58wwmp 4143 3 of of IN cord-015306-us58wwmp 4143 4 the the DT cord-015306-us58wwmp 4143 5 present present JJ cord-015306-us58wwmp 4143 6 study study NN cord-015306-us58wwmp 4143 7 was be VBD cord-015306-us58wwmp 4143 8 to to TO cord-015306-us58wwmp 4143 9 investigate investigate VB cord-015306-us58wwmp 4143 10 the the DT cord-015306-us58wwmp 4143 11 vitamin vitamin NN cord-015306-us58wwmp 4143 12 D d NN cord-015306-us58wwmp 4143 13 status status NN cord-015306-us58wwmp 4143 14 in in IN cord-015306-us58wwmp 4143 15 3 3 CD cord-015306-us58wwmp 4143 16 groups group NNS cord-015306-us58wwmp 4143 17 of of IN cord-015306-us58wwmp 4143 18 children child NNS cord-015306-us58wwmp 4143 19 and and CC cord-015306-us58wwmp 4143 20 adolescents adolescent NNS cord-015306-us58wwmp 4143 21 with with IN cord-015306-us58wwmp 4143 22 CKD CKD NNP cord-015306-us58wwmp 4143 23 and and CC cord-015306-us58wwmp 4143 24 to to TO cord-015306-us58wwmp 4143 25 establish establish VB cord-015306-us58wwmp 4143 26 the the DT cord-015306-us58wwmp 4143 27 association association NN cord-015306-us58wwmp 4143 28 between between IN cord-015306-us58wwmp 4143 29 25(OH 25(oh CD cord-015306-us58wwmp 4143 30 ) ) -RRB- cord-015306-us58wwmp 4144 1 vitamin vitamin NN cord-015306-us58wwmp 4144 2 D D NNP cord-015306-us58wwmp 4144 3 ( ( -LRB- cord-015306-us58wwmp 4144 4 25OHD 25ohd CD cord-015306-us58wwmp 4144 5 ) ) -RRB- cord-015306-us58wwmp 4144 6 levels level NNS cord-015306-us58wwmp 4144 7 , , , cord-015306-us58wwmp 4144 8 age age NN cord-015306-us58wwmp 4144 9 , , , cord-015306-us58wwmp 4144 10 hyperparathyroidism hyperparathyroidism NN cord-015306-us58wwmp 4144 11 , , , cord-015306-us58wwmp 4144 12 short short JJ cord-015306-us58wwmp 4144 13 stature stature NN cord-015306-us58wwmp 4144 14 , , , cord-015306-us58wwmp 4144 15 and and CC cord-015306-us58wwmp 4144 16 renal renal JJ cord-015306-us58wwmp 4144 17 function function NN cord-015306-us58wwmp 4144 18 . . . cord-015306-us58wwmp 4145 1 Methods method NNS cord-015306-us58wwmp 4145 2 : : : cord-015306-us58wwmp 4145 3 We -PRON- PRP cord-015306-us58wwmp 4145 4 recruited recruit VBD cord-015306-us58wwmp 4145 5 105 105 CD cord-015306-us58wwmp 4145 6 children child NNS cord-015306-us58wwmp 4145 7 : : : cord-015306-us58wwmp 4145 8 44 44 CD cord-015306-us58wwmp 4145 9 renal renal JJ cord-015306-us58wwmp 4145 10 transplant transplant NN cord-015306-us58wwmp 4145 11 patients patient NNS cord-015306-us58wwmp 4145 12 with with IN cord-015306-us58wwmp 4145 13 a a DT cord-015306-us58wwmp 4145 14 functioning functioning JJ cord-015306-us58wwmp 4145 15 graft graft NN cord-015306-us58wwmp 4145 16 for for IN cord-015306-us58wwmp 4145 17 at at RB cord-015306-us58wwmp 4145 18 least least RBS cord-015306-us58wwmp 4145 19 6 6 CD cord-015306-us58wwmp 4145 20 months month NNS cord-015306-us58wwmp 4145 21 ( ( -LRB- cord-015306-us58wwmp 4145 22 mean mean VB cord-015306-us58wwmp 4145 23 age age NN cord-015306-us58wwmp 4145 24 12 12 CD cord-015306-us58wwmp 4145 25 yr yr NN cord-015306-us58wwmp 4145 26 , , , cord-015306-us58wwmp 4145 27 mean mean JJ cord-015306-us58wwmp 4145 28 graft graft NN cord-015306-us58wwmp 4145 29 Abstract Abstract NNP cord-015306-us58wwmp 4145 30 # # NN cord-015306-us58wwmp 4145 31 P- P- NNP cord-015306-us58wwmp 4146 1 SAT386 SAT386 NNP cord-015306-us58wwmp 4147 1 The the DT cord-015306-us58wwmp 4147 2 expression expression NN cord-015306-us58wwmp 4147 3 and and CC cord-015306-us58wwmp 4147 4 significance significance NN cord-015306-us58wwmp 4147 5 of of IN cord-015306-us58wwmp 4147 6 IL-6 IL-6 NNP cord-015306-us58wwmp 4147 7 、 、 NNP cord-015306-us58wwmp 4147 8 IP-10 IP-10 NNP cord-015306-us58wwmp 4147 9 and and CC cord-015306-us58wwmp 4147 10 IL-17 IL-17 NNP cord-015306-us58wwmp 4147 11 in in IN cord-015306-us58wwmp 4147 12 serum serum NN cord-015306-us58wwmp 4147 13 and and CC cord-015306-us58wwmp 4147 14 synovial synovial JJ cord-015306-us58wwmp 4147 15 fluid fluid NN cord-015306-us58wwmp 4147 16 with with IN cord-015306-us58wwmp 4147 17 juvenile juvenile JJ cord-015306-us58wwmp 4147 18 idiopathic idiopathic JJ cord-015306-us58wwmp 4147 19 arthritis arthritis NN cord-015306-us58wwmp 4147 20 . . . cord-015306-us58wwmp 4148 1 Objective objective NN cord-015306-us58wwmp 4148 2 : : : cord-015306-us58wwmp 4148 3 To to TO cord-015306-us58wwmp 4148 4 detect detect VB cord-015306-us58wwmp 4148 5 the the DT cord-015306-us58wwmp 4148 6 disparity disparity NN cord-015306-us58wwmp 4148 7 of of IN cord-015306-us58wwmp 4148 8 three three CD cord-015306-us58wwmp 4148 9 cytokines cytokine NNS cord-015306-us58wwmp 4148 10 about about IN cord-015306-us58wwmp 4148 11 Interleukin-6(IL-6),Interferon interleukin-6(il-6),interferon RB cord-015306-us58wwmp 4148 12 - - HYPH cord-015306-us58wwmp 4148 13 inducible inducible JJ cord-015306-us58wwmp 4148 14 protein protein NN cord-015306-us58wwmp 4148 15 10(IP-10 10(ip-10 CD cord-015306-us58wwmp 4148 16 ) ) -RRB- cord-015306-us58wwmp 4148 17 and and CC cord-015306-us58wwmp 4148 18 in in IN cord-015306-us58wwmp 4148 19 peripheral peripheral JJ cord-015306-us58wwmp 4148 20 blood(PB blood(PB NNP cord-015306-us58wwmp 4148 21 ) ) -RRB- cord-015306-us58wwmp 4148 22 and and CC cord-015306-us58wwmp 4148 23 synovial synovial JJ cord-015306-us58wwmp 4148 24 fluid(SF fluid(sf ADD cord-015306-us58wwmp 4148 25 ) ) -RRB- cord-015306-us58wwmp 4148 26 of of IN cord-015306-us58wwmp 4148 27 patients patient NNS cord-015306-us58wwmp 4148 28 with with IN cord-015306-us58wwmp 4148 29 juvenile juvenile JJ cord-015306-us58wwmp 4148 30 idiopathic idiopathic JJ cord-015306-us58wwmp 4148 31 arthritis arthritis NN cord-015306-us58wwmp 4148 32 ( ( -LRB- cord-015306-us58wwmp 4148 33 JIA JIA NNP cord-015306-us58wwmp 4148 34 ) ) -RRB- cord-015306-us58wwmp 4148 35 . . . cord-015306-us58wwmp 4149 1 Method method NN cord-015306-us58wwmp 4149 2 : : : cord-015306-us58wwmp 4150 1 Serum serum NN cord-015306-us58wwmp 4150 2 concentrations concentration NNS cord-015306-us58wwmp 4150 3 of of IN cord-015306-us58wwmp 4150 4 the the DT cord-015306-us58wwmp 4150 5 three three CD cord-015306-us58wwmp 4150 6 cytokines cytokine NNS cord-015306-us58wwmp 4150 7 were be VBD cord-015306-us58wwmp 4150 8 measured measure VBN cord-015306-us58wwmp 4150 9 in in IN cord-015306-us58wwmp 4150 10 27 27 CD cord-015306-us58wwmp 4150 11 patients patient NNS cord-015306-us58wwmp 4150 12 with with IN cord-015306-us58wwmp 4150 13 13 13 CD cord-015306-us58wwmp 4150 14 systemic systemic JJ cord-015306-us58wwmp 4150 15 - - HYPH cord-015306-us58wwmp 4150 16 onset onset NN cord-015306-us58wwmp 4150 17 JIA(sJIA jia(sjia NN cord-015306-us58wwmp 4150 18 ) ) -RRB- cord-015306-us58wwmp 4150 19 , , , cord-015306-us58wwmp 4150 20 14 14 CD cord-015306-us58wwmp 4150 21 polyarticular polyarticular JJ cord-015306-us58wwmp 4150 22 JIA(pJIA JIA(pJIA NNP cord-015306-us58wwmp 4150 23 ) ) -RRB- cord-015306-us58wwmp 4150 24 and and CC cord-015306-us58wwmp 4150 25 28 28 CD cord-015306-us58wwmp 4150 26 healthy healthy JJ cord-015306-us58wwmp 4150 27 controls control NNS cord-015306-us58wwmp 4150 28 using use VBG cord-015306-us58wwmp 4150 29 enzyme enzyme NN cord-015306-us58wwmp 4150 30 - - HYPH cord-015306-us58wwmp 4150 31 linked link VBN cord-015306-us58wwmp 4150 32 immunoabsorbent immunoabsorbent NN cord-015306-us58wwmp 4150 33 assays assays NNP cord-015306-us58wwmp 4150 34 ( ( -LRB- cord-015306-us58wwmp 4150 35 ELISA ELISA NNP cord-015306-us58wwmp 4150 36 ) ) -RRB- cord-015306-us58wwmp 4150 37 . . . cord-015306-us58wwmp 4151 1 19 19 CD cord-015306-us58wwmp 4151 2 patients patient NNS cord-015306-us58wwmp 4151 3 being be VBG cord-015306-us58wwmp 4151 4 no no DT cord-015306-us58wwmp 4151 5 marked mark VBN cord-015306-us58wwmp 4151 6 arthritis arthritis NN cord-015306-us58wwmp 4151 7 symptom symptom NN cord-015306-us58wwmp 4151 8 or or CC cord-015306-us58wwmp 4151 9 only only RB cord-015306-us58wwmp 4151 10 temporary temporary JJ cord-015306-us58wwmp 4151 11 arthralgia arthralgia NN cord-015306-us58wwmp 4151 12 enrolled enrol VBN cord-015306-us58wwmp 4151 13 in in IN cord-015306-us58wwmp 4151 14 probable probable JJ cord-015306-us58wwmp 4151 15 sJIA sjia JJ cord-015306-us58wwmp 4151 16 group group NN cord-015306-us58wwmp 4151 17 . . . cord-015306-us58wwmp 4152 1 SF SF NNP cord-015306-us58wwmp 4152 2 from from IN cord-015306-us58wwmp 4152 3 18 18 CD cord-015306-us58wwmp 4152 4 patients patient NNS cord-015306-us58wwmp 4152 5 with with IN cord-015306-us58wwmp 4152 6 7 7 CD cord-015306-us58wwmp 4152 7 sJIA,11pJIA sjia,11pjia NN cord-015306-us58wwmp 4152 8 were be VBD cord-015306-us58wwmp 4152 9 examined examine VBN cord-015306-us58wwmp 4152 10 for for IN cord-015306-us58wwmp 4152 11 cytokine cytokine NN cord-015306-us58wwmp 4152 12 levels level NNS cord-015306-us58wwmp 4152 13 . . . cord-015306-us58wwmp 4153 1 Objective objective NN cord-015306-us58wwmp 4153 2 : : : cord-015306-us58wwmp 4154 1 The the DT cord-015306-us58wwmp 4154 2 aim aim NN cord-015306-us58wwmp 4154 3 of of IN cord-015306-us58wwmp 4154 4 the the DT cord-015306-us58wwmp 4154 5 present present JJ cord-015306-us58wwmp 4154 6 study study NN cord-015306-us58wwmp 4154 7 is be VBZ cord-015306-us58wwmp 4154 8 to to TO cord-015306-us58wwmp 4154 9 evaluate evaluate VB cord-015306-us58wwmp 4154 10 serum serum NN cord-015306-us58wwmp 4154 11 concentrations concentration NNS cord-015306-us58wwmp 4154 12 of of IN cord-015306-us58wwmp 4154 13 ghrelin ghrelin NN cord-015306-us58wwmp 4154 14 and and CC cord-015306-us58wwmp 4154 15 leptin leptin NN cord-015306-us58wwmp 4154 16 , , , cord-015306-us58wwmp 4154 17 and and CC cord-015306-us58wwmp 4154 18 their -PRON- PRP$ cord-015306-us58wwmp 4154 19 associations association NNS cord-015306-us58wwmp 4154 20 with with IN cord-015306-us58wwmp 4154 21 fat fat JJ cord-015306-us58wwmp 4154 22 mass mass NN cord-015306-us58wwmp 4154 23 and and CC cord-015306-us58wwmp 4154 24 insulin insulin NN cord-015306-us58wwmp 4154 25 homeostasis homeostasis NN cord-015306-us58wwmp 4154 26 in in IN cord-015306-us58wwmp 4154 27 children child NNS cord-015306-us58wwmp 4154 28 undergoing undergo VBG cord-015306-us58wwmp 4154 29 chronic chronic JJ cord-015306-us58wwmp 4154 30 dialysis dialysis NN cord-015306-us58wwmp 4154 31 . . . cord-015306-us58wwmp 4155 1 Methods method NNS cord-015306-us58wwmp 4155 2 : : : cord-015306-us58wwmp 4155 3 The the DT cord-015306-us58wwmp 4155 4 study study NN cord-015306-us58wwmp 4155 5 population population NN cord-015306-us58wwmp 4155 6 consisted consist VBD cord-015306-us58wwmp 4155 7 of of IN cord-015306-us58wwmp 4155 8 40 40 CD cord-015306-us58wwmp 4155 9 patients patient NNS cord-015306-us58wwmp 4155 10 on on IN cord-015306-us58wwmp 4155 11 maintenance maintenance NN cord-015306-us58wwmp 4155 12 dialysis dialysis NN cord-015306-us58wwmp 4155 13 ( ( -LRB- cord-015306-us58wwmp 4155 14 22 22 CD cord-015306-us58wwmp 4155 15 PD PD NNP cord-015306-us58wwmp 4155 16 and and CC cord-015306-us58wwmp 4155 17 18 18 CD cord-015306-us58wwmp 4155 18 HD hd NN cord-015306-us58wwmp 4155 19 ) ) -RRB- cord-015306-us58wwmp 4155 20 aged age VBN cord-015306-us58wwmp 4155 21 between between IN cord-015306-us58wwmp 4155 22 5 5 CD cord-015306-us58wwmp 4155 23 - - SYM cord-015306-us58wwmp 4155 24 19 19 CD cord-015306-us58wwmp 4155 25 years year NNS cord-015306-us58wwmp 4155 26 and and CC cord-015306-us58wwmp 4155 27 20 20 CD cord-015306-us58wwmp 4155 28 age age NN cord-015306-us58wwmp 4155 29 - - HYPH cord-015306-us58wwmp 4155 30 and and CC cord-015306-us58wwmp 4155 31 sex sex NN cord-015306-us58wwmp 4155 32 - - HYPH cord-015306-us58wwmp 4155 33 matched match VBN cord-015306-us58wwmp 4155 34 healthy healthy JJ cord-015306-us58wwmp 4155 35 children child NNS cord-015306-us58wwmp 4155 36 . . . cord-015306-us58wwmp 4156 1 Serum serum NN cord-015306-us58wwmp 4156 2 levels level NNS cord-015306-us58wwmp 4156 3 of of IN cord-015306-us58wwmp 4156 4 total total JJ cord-015306-us58wwmp 4156 5 ghrelin ghrelin NN cord-015306-us58wwmp 4156 6 and and CC cord-015306-us58wwmp 4156 7 leptin leptin NN cord-015306-us58wwmp 4156 8 were be VBD cord-015306-us58wwmp 4156 9 measured measure VBN cord-015306-us58wwmp 4156 10 in in IN cord-015306-us58wwmp 4156 11 all all DT cord-015306-us58wwmp 4156 12 patients patient NNS cord-015306-us58wwmp 4156 13 and and CC cord-015306-us58wwmp 4156 14 controls control NNS cord-015306-us58wwmp 4156 15 . . . cord-015306-us58wwmp 4157 1 Fasting fast VBG cord-015306-us58wwmp 4157 2 serum serum NN cord-015306-us58wwmp 4157 3 glucose glucose NN cord-015306-us58wwmp 4157 4 and and CC cord-015306-us58wwmp 4157 5 insulin insulin NN cord-015306-us58wwmp 4157 6 levels level NNS cord-015306-us58wwmp 4157 7 were be VBD cord-015306-us58wwmp 4157 8 also also RB cord-015306-us58wwmp 4157 9 measured measure VBN cord-015306-us58wwmp 4157 10 in in IN cord-015306-us58wwmp 4157 11 the the DT cord-015306-us58wwmp 4157 12 patients patient NNS cord-015306-us58wwmp 4157 13 ; ; : cord-015306-us58wwmp 4157 14 insulin insulin NN cord-015306-us58wwmp 4157 15 resistance resistance NN cord-015306-us58wwmp 4157 16 was be VBD cord-015306-us58wwmp 4157 17 estimated estimate VBN cord-015306-us58wwmp 4157 18 by by IN cord-015306-us58wwmp 4157 19 the the DT cord-015306-us58wwmp 4157 20 homeostasis homeostasis NN cord-015306-us58wwmp 4157 21 model model NN cord-015306-us58wwmp 4157 22 assessment assessment NN cord-015306-us58wwmp 4157 23 of of IN cord-015306-us58wwmp 4157 24 insulin insulin NN cord-015306-us58wwmp 4157 25 resistance resistance NN cord-015306-us58wwmp 4157 26 ( ( -LRB- cord-015306-us58wwmp 4157 27 HOMA HOMA NNP cord-015306-us58wwmp 4157 28 - - HYPH cord-015306-us58wwmp 4157 29 IR IR NNP cord-015306-us58wwmp 4157 30 ) ) -RRB- cord-015306-us58wwmp 4157 31 . . . cord-015306-us58wwmp 4158 1 Nutritional nutritional JJ cord-015306-us58wwmp 4158 2 status status NN cord-015306-us58wwmp 4158 3 was be VBD cord-015306-us58wwmp 4158 4 assessed assess VBN cord-015306-us58wwmp 4158 5 by by IN cord-015306-us58wwmp 4158 6 measuring measure VBG cord-015306-us58wwmp 4158 7 body body NN cord-015306-us58wwmp 4158 8 mass mass NN cord-015306-us58wwmp 4158 9 index index NN cord-015306-us58wwmp 4158 10 ( ( -LRB- cord-015306-us58wwmp 4158 11 BMI BMI NNP cord-015306-us58wwmp 4158 12 ) ) -RRB- cord-015306-us58wwmp 4158 13 , , , cord-015306-us58wwmp 4158 14 triceps triceps JJ cord-015306-us58wwmp 4158 15 skinfold skinfold JJ cord-015306-us58wwmp 4158 16 thickness thickness NN cord-015306-us58wwmp 4158 17 ( ( -LRB- cord-015306-us58wwmp 4158 18 TSF TSF NNP cord-015306-us58wwmp 4158 19 ) ) -RRB- cord-015306-us58wwmp 4158 20 and and CC cord-015306-us58wwmp 4158 21 multi multi JJ cord-015306-us58wwmp 4158 22 - - JJ cord-015306-us58wwmp 4158 23 frequency frequency JJ cord-015306-us58wwmp 4158 24 bioimpedance bioimpedance NN cord-015306-us58wwmp 4158 25 analysis analysis NN cord-015306-us58wwmp 4158 26 ( ( -LRB- cord-015306-us58wwmp 4158 27 BIA BIA NNP cord-015306-us58wwmp 4158 28 ) ) -RRB- cord-015306-us58wwmp 4158 29 . . . cord-015306-us58wwmp 4159 1 Body body NN cord-015306-us58wwmp 4159 2 fat fat JJ cord-015306-us58wwmp 4159 3 mass mass NN cord-015306-us58wwmp 4159 4 was be VBD cord-015306-us58wwmp 4159 5 estimated estimate VBN cord-015306-us58wwmp 4159 6 by by IN cord-015306-us58wwmp 4159 7 the the DT cord-015306-us58wwmp 4159 8 BIA BIA NNP cord-015306-us58wwmp 4159 9 method method NN cord-015306-us58wwmp 4159 10 . . . cord-015306-us58wwmp 4160 1 Results result NNS cord-015306-us58wwmp 4160 2 : : : cord-015306-us58wwmp 4161 1 The the DT cord-015306-us58wwmp 4161 2 mean mean JJ cord-015306-us58wwmp 4161 3 total total JJ cord-015306-us58wwmp 4161 4 ghrelin ghrelin NN cord-015306-us58wwmp 4161 5 level level NN cord-015306-us58wwmp 4161 6 was be VBD cord-015306-us58wwmp 4161 7 significantly significantly RB cord-015306-us58wwmp 4161 8 higher high JJR cord-015306-us58wwmp 4161 9 in in IN cord-015306-us58wwmp 4161 10 the the DT cord-015306-us58wwmp 4161 11 patients patient NNS cord-015306-us58wwmp 4161 12 than than IN cord-015306-us58wwmp 4161 13 the the DT cord-015306-us58wwmp 4161 14 controls control NNS cord-015306-us58wwmp 4161 15 ( ( -LRB- cord-015306-us58wwmp 4161 16 1671±1317 1671±1317 CD cord-015306-us58wwmp 4161 17 vs. vs. NN cord-015306-us58wwmp 4161 18 543±365 543±365 CD cord-015306-us58wwmp 4161 19 pg pg NNP cord-015306-us58wwmp 4161 20 / / SYM cord-015306-us58wwmp 4161 21 mL mL NNP cord-015306-us58wwmp 4161 22 , , , cord-015306-us58wwmp 4161 23 p<0.001 p<0.001 CD cord-015306-us58wwmp 4161 24 ) ) -RRB- cord-015306-us58wwmp 4161 25 . . . cord-015306-us58wwmp 4162 1 Higher high JJR cord-015306-us58wwmp 4162 2 total total JJ cord-015306-us58wwmp 4162 3 ghrelin ghrelin NN cord-015306-us58wwmp 4162 4 levels level NNS cord-015306-us58wwmp 4162 5 in in IN cord-015306-us58wwmp 4162 6 dialysis dialysis NN cord-015306-us58wwmp 4162 7 patients patient NNS cord-015306-us58wwmp 4162 8 were be VBD cord-015306-us58wwmp 4162 9 significantly significantly RB cord-015306-us58wwmp 4162 10 associated associate VBN cord-015306-us58wwmp 4162 11 with with IN cord-015306-us58wwmp 4162 12 younger young JJR cord-015306-us58wwmp 4162 13 age age NN cord-015306-us58wwmp 4162 14 ( ( -LRB- cord-015306-us58wwmp 4162 15 p=0.015 p=0.015 NNP cord-015306-us58wwmp 4162 16 ) ) -RRB- cord-015306-us58wwmp 4162 17 , , , cord-015306-us58wwmp 4162 18 lower low JJR cord-015306-us58wwmp 4162 19 BMI BMI NNP cord-015306-us58wwmp 4162 20 - - HYPH cord-015306-us58wwmp 4162 21 SDS SDS NNP cord-015306-us58wwmp 4162 22 ( ( -LRB- cord-015306-us58wwmp 4162 23 p=0.050 p=0.050 NNP cord-015306-us58wwmp 4162 24 ) ) -RRB- cord-015306-us58wwmp 4162 25 and and CC cord-015306-us58wwmp 4162 26 lower low JJR cord-015306-us58wwmp 4162 27 BIA BIA NNP cord-015306-us58wwmp 4162 28 - - HYPH cord-015306-us58wwmp 4162 29 based base VBN cord-015306-us58wwmp 4162 30 fat fat JJ cord-015306-us58wwmp 4162 31 mass mass NNP cord-015306-us58wwmp 4162 32 - - HYPH cord-015306-us58wwmp 4162 33 z z NN cord-015306-us58wwmp 4162 34 score score NN cord-015306-us58wwmp 4162 35 ( ( -LRB- cord-015306-us58wwmp 4162 36 p=0.007 p=0.007 NNP cord-015306-us58wwmp 4162 37 ) ) -RRB- cord-015306-us58wwmp 4162 38 . . . cord-015306-us58wwmp 4163 1 The the DT cord-015306-us58wwmp 4163 2 mean mean JJ cord-015306-us58wwmp 4163 3 leptin leptin NN cord-015306-us58wwmp 4163 4 level level NN cord-015306-us58wwmp 4163 5 was be VBD cord-015306-us58wwmp 4163 6 also also RB cord-015306-us58wwmp 4163 7 higher high JJR cord-015306-us58wwmp 4163 8 in in IN cord-015306-us58wwmp 4163 9 dialysis dialysis NN cord-015306-us58wwmp 4163 10 patients patient NNS cord-015306-us58wwmp 4163 11 compared compare VBN cord-015306-us58wwmp 4163 12 to to IN cord-015306-us58wwmp 4163 13 the the DT cord-015306-us58wwmp 4163 14 controls control NNS cord-015306-us58wwmp 4163 15 but but CC cord-015306-us58wwmp 4163 16 the the DT cord-015306-us58wwmp 4163 17 difference difference NN cord-015306-us58wwmp 4163 18 was be VBD cord-015306-us58wwmp 4163 19 not not RB cord-015306-us58wwmp 4163 20 statistically statistically RB cord-015306-us58wwmp 4163 21 significant significant JJ cord-015306-us58wwmp 4163 22 ( ( -LRB- cord-015306-us58wwmp 4163 23 15.5±29.2 15.5±29.2 CD cord-015306-us58wwmp 4163 24 vs. vs. FW cord-015306-us58wwmp 4163 25 6.48±5.51 6.48±5.51 CD cord-015306-us58wwmp 4163 26 ng ng NNP cord-015306-us58wwmp 4163 27 / / SYM cord-015306-us58wwmp 4163 28 mL ml NN cord-015306-us58wwmp 4163 29 ) ) -RRB- cord-015306-us58wwmp 4163 30 . . . cord-015306-us58wwmp 4164 1 However however RB cord-015306-us58wwmp 4164 2 , , , cord-015306-us58wwmp 4164 3 the the DT cord-015306-us58wwmp 4164 4 ratio ratio NN cord-015306-us58wwmp 4164 5 of of IN cord-015306-us58wwmp 4164 6 leptin leptin NN cord-015306-us58wwmp 4164 7 levels level NNS cord-015306-us58wwmp 4164 8 to to IN cord-015306-us58wwmp 4164 9 fat fat JJ cord-015306-us58wwmp 4164 10 mass mass NN cord-015306-us58wwmp 4164 11 was be VBD cord-015306-us58wwmp 4164 12 significantly significantly RB cord-015306-us58wwmp 4164 13 higher high JJR cord-015306-us58wwmp 4164 14 in in IN cord-015306-us58wwmp 4164 15 dialysis dialysis NN cord-015306-us58wwmp 4164 16 patients patient NNS cord-015306-us58wwmp 4164 17 than than IN cord-015306-us58wwmp 4164 18 the the DT cord-015306-us58wwmp 4164 19 controls control NNS cord-015306-us58wwmp 4164 20 ( ( -LRB- cord-015306-us58wwmp 4164 21 1.16±1.31 1.16±1.31 CD cord-015306-us58wwmp 4164 22 vs. vs. IN cord-015306-us58wwmp 4164 23 0.50±0.12 0.50±0.12 CD cord-015306-us58wwmp 4164 24 , , , cord-015306-us58wwmp 4164 25 p=0.041 p=0.041 NNP cord-015306-us58wwmp 4164 26 ) ) -RRB- cord-015306-us58wwmp 4164 27 . . . cord-015306-us58wwmp 4165 1 Serum serum NN cord-015306-us58wwmp 4165 2 levels level NNS cord-015306-us58wwmp 4165 3 of of IN cord-015306-us58wwmp 4165 4 leptin leptin NN cord-015306-us58wwmp 4165 5 in in IN cord-015306-us58wwmp 4165 6 dialysis dialysis NN cord-015306-us58wwmp 4165 7 patients patient NNS cord-015306-us58wwmp 4165 8 positively positively RB cord-015306-us58wwmp 4165 9 correlated correlate VBN cord-015306-us58wwmp 4165 10 with with IN cord-015306-us58wwmp 4165 11 BMI BMI NNP cord-015306-us58wwmp 4165 12 - - HYPH cord-015306-us58wwmp 4165 13 SDS SDS NNP cord-015306-us58wwmp 4165 14 , , , cord-015306-us58wwmp 4165 15 TSF TSF NNP cord-015306-us58wwmp 4165 16 - - HYPH cord-015306-us58wwmp 4165 17 z z NNP cord-015306-us58wwmp 4165 18 score score NN cord-015306-us58wwmp 4165 19 and and CC cord-015306-us58wwmp 4165 20 BIA BIA NNP cord-015306-us58wwmp 4165 21 - - HYPH cord-015306-us58wwmp 4165 22 based base VBN cord-015306-us58wwmp 4165 23 fat fat JJ cord-015306-us58wwmp 4165 24 mass mass NNP cord-015306-us58wwmp 4165 25 - - HYPH cord-015306-us58wwmp 4165 26 z z NN cord-015306-us58wwmp 4165 27 score score NN cord-015306-us58wwmp 4165 28 ( ( -LRB- cord-015306-us58wwmp 4165 29 p<0.001 p<0.001 NNS cord-015306-us58wwmp 4165 30 for for IN cord-015306-us58wwmp 4165 31 all all DT cord-015306-us58wwmp 4165 32 ) ) -RRB- cord-015306-us58wwmp 4165 33 . . . cord-015306-us58wwmp 4166 1 Serum serum NN cord-015306-us58wwmp 4166 2 leptin leptin NN cord-015306-us58wwmp 4166 3 levels level NNS cord-015306-us58wwmp 4166 4 also also RB cord-015306-us58wwmp 4166 5 had have VBD cord-015306-us58wwmp 4166 6 a a DT cord-015306-us58wwmp 4166 7 positive positive JJ cord-015306-us58wwmp 4166 8 correlation correlation NN cord-015306-us58wwmp 4166 9 with with IN cord-015306-us58wwmp 4166 10 serum serum NN cord-015306-us58wwmp 4166 11 insulin insulin NN cord-015306-us58wwmp 4166 12 ( ( -LRB- cord-015306-us58wwmp 4166 13 p=0.001 p=0.001 NNP cord-015306-us58wwmp 4166 14 ) ) -RRB- cord-015306-us58wwmp 4166 15 and and CC cord-015306-us58wwmp 4166 16 HOMA HOMA NNP cord-015306-us58wwmp 4166 17 - - HYPH cord-015306-us58wwmp 4166 18 IR IR NNP cord-015306-us58wwmp 4166 19 ( ( -LRB- cord-015306-us58wwmp 4166 20 p<0.001 p<0.001 JJ cord-015306-us58wwmp 4166 21 ) ) -RRB- cord-015306-us58wwmp 4166 22 , , , cord-015306-us58wwmp 4166 23 and and CC cord-015306-us58wwmp 4166 24 an an DT cord-015306-us58wwmp 4166 25 inverse inverse JJ cord-015306-us58wwmp 4166 26 correlation correlation NN cord-015306-us58wwmp 4166 27 with with IN cord-015306-us58wwmp 4166 28 total total JJ cord-015306-us58wwmp 4166 29 ghrelin ghrelin NN cord-015306-us58wwmp 4166 30 level level NN cord-015306-us58wwmp 4166 31 ( ( -LRB- cord-015306-us58wwmp 4166 32 p=0.005 p=0.005 NNP cord-015306-us58wwmp 4166 33 ) ) -RRB- cord-015306-us58wwmp 4166 34 . . . cord-015306-us58wwmp 4167 1 Conclusion conclusion NN cord-015306-us58wwmp 4167 2 : : : cord-015306-us58wwmp 4167 3 Children child NNS cord-015306-us58wwmp 4167 4 on on IN cord-015306-us58wwmp 4167 5 maintenance maintenance NN cord-015306-us58wwmp 4167 6 dialysis dialysis NN cord-015306-us58wwmp 4167 7 have have VBP cord-015306-us58wwmp 4167 8 high high JJ cord-015306-us58wwmp 4167 9 levels level NNS cord-015306-us58wwmp 4167 10 of of IN cord-015306-us58wwmp 4167 11 total total JJ cord-015306-us58wwmp 4167 12 ghrelin ghrelin NN cord-015306-us58wwmp 4167 13 that that WDT cord-015306-us58wwmp 4167 14 are be VBP cord-015306-us58wwmp 4167 15 closely closely RB cord-015306-us58wwmp 4167 16 related relate VBN cord-015306-us58wwmp 4167 17 to to IN cord-015306-us58wwmp 4167 18 decreased decrease VBN cord-015306-us58wwmp 4167 19 fat fat JJ cord-015306-us58wwmp 4167 20 mass mass NN cord-015306-us58wwmp 4167 21 and and CC cord-015306-us58wwmp 4167 22 poor poor JJ cord-015306-us58wwmp 4167 23 nutritional nutritional JJ cord-015306-us58wwmp 4167 24 status status NN cord-015306-us58wwmp 4167 25 . . . cord-015306-us58wwmp 4168 1 In in IN cord-015306-us58wwmp 4168 2 contrast contrast NN cord-015306-us58wwmp 4168 3 to to IN cord-015306-us58wwmp 4168 4 ghrelin ghrelin NN cord-015306-us58wwmp 4168 5 , , , cord-015306-us58wwmp 4168 6 leptin leptin NN cord-015306-us58wwmp 4168 7 is be VBZ cord-015306-us58wwmp 4168 8 associated associate VBN cord-015306-us58wwmp 4168 9 with with IN cord-015306-us58wwmp 4168 10 increased increase VBN cord-015306-us58wwmp 4168 11 fat fat JJ cord-015306-us58wwmp 4168 12 mass mass NN cord-015306-us58wwmp 4168 13 and and CC cord-015306-us58wwmp 4168 14 insulin insulin NN cord-015306-us58wwmp 4168 15 resistance resistance NN cord-015306-us58wwmp 4168 16 ; ; : cord-015306-us58wwmp 4168 17 however however RB cord-015306-us58wwmp 4168 18 , , , cord-015306-us58wwmp 4168 19 these these DT cord-015306-us58wwmp 4168 20 patients patient NNS cord-015306-us58wwmp 4168 21 have have VBP cord-015306-us58wwmp 4168 22 inappropriately inappropriately RB cord-015306-us58wwmp 4168 23 elevated elevate VBN cord-015306-us58wwmp 4168 24 leptin leptin NN cord-015306-us58wwmp 4168 25 levels level NNS cord-015306-us58wwmp 4168 26 in in IN cord-015306-us58wwmp 4168 27 relation relation NN cord-015306-us58wwmp 4168 28 to to IN cord-015306-us58wwmp 4168 29 body body NN cord-015306-us58wwmp 4168 30 fat fat NN cord-015306-us58wwmp 4168 31 mass mass NN cord-015306-us58wwmp 4168 32 that that WDT cord-015306-us58wwmp 4168 33 may may MD cord-015306-us58wwmp 4168 34 be be VB cord-015306-us58wwmp 4168 35 related relate VBN cord-015306-us58wwmp 4168 36 to to IN cord-015306-us58wwmp 4168 37 wasting waste VBG cord-015306-us58wwmp 4168 38 . . . cord-015306-us58wwmp 4169 1 Objective objective NN cord-015306-us58wwmp 4169 2 : : : cord-015306-us58wwmp 4170 1 This this DT cord-015306-us58wwmp 4170 2 study study NN cord-015306-us58wwmp 4170 3 investigated investigate VBD cord-015306-us58wwmp 4170 4 the the DT cord-015306-us58wwmp 4170 5 influence influence NN cord-015306-us58wwmp 4170 6 of of IN cord-015306-us58wwmp 4170 7 social social JJ cord-015306-us58wwmp 4170 8 support support NN cord-015306-us58wwmp 4170 9 and and CC cord-015306-us58wwmp 4170 10 other other JJ cord-015306-us58wwmp 4170 11 psychosocial psychosocial JJ cord-015306-us58wwmp 4170 12 factors factor NNS cord-015306-us58wwmp 4170 13 upon upon IN cord-015306-us58wwmp 4170 14 mortality mortality NN cord-015306-us58wwmp 4170 15 , , , cord-015306-us58wwmp 4170 16 adherence adherence NN cord-015306-us58wwmp 4170 17 to to IN cord-015306-us58wwmp 4170 18 medical medical JJ cord-015306-us58wwmp 4170 19 care care NN cord-015306-us58wwmp 4170 20 recommendations recommendation NNS cord-015306-us58wwmp 4170 21 , , , cord-015306-us58wwmp 4170 22 and and CC cord-015306-us58wwmp 4170 23 physical physical JJ cord-015306-us58wwmp 4170 24 QoL qol NN cord-015306-us58wwmp 4170 25 amongst amongst IN cord-015306-us58wwmp 4170 26 hemodialysis hemodialysis NN cord-015306-us58wwmp 4170 27 patients patient NNS cord-015306-us58wwmp 4170 28 . . . cord-015306-us58wwmp 4171 1 Method method NN cord-015306-us58wwmp 4171 2 : : : cord-015306-us58wwmp 4171 3 272 272 CD cord-015306-us58wwmp 4171 4 HD hd NN cord-015306-us58wwmp 4171 5 patients patient NNS cord-015306-us58wwmp 4171 6 were be VBD cord-015306-us58wwmp 4171 7 examined examine VBN cord-015306-us58wwmp 4171 8 using use VBG cord-015306-us58wwmp 4171 9 the the DT cord-015306-us58wwmp 4171 10 QoL QoL NNP cord-015306-us58wwmp 4171 11 questionnaire questionnaire NN cord-015306-us58wwmp 4171 12 to to TO cord-015306-us58wwmp 4171 13 determine determine VB cord-015306-us58wwmp 4171 14 self self NN cord-015306-us58wwmp 4171 15 - - HYPH cord-015306-us58wwmp 4171 16 reported report VBN cord-015306-us58wwmp 4171 17 inclinations inclination NNS cord-015306-us58wwmp 4171 18 . . . cord-015306-us58wwmp 4172 1 Logistics logistic NNS cord-015306-us58wwmp 4172 2 regression regression NN cord-015306-us58wwmp 4172 3 through through IN cord-015306-us58wwmp 4172 4 Weighted Weighted NNP cord-015306-us58wwmp 4172 5 K K NNP cord-015306-us58wwmp 4172 6 was be VBD cord-015306-us58wwmp 4172 7 used use VBN cord-015306-us58wwmp 4172 8 to to TO cord-015306-us58wwmp 4172 9 analyze analyze VB cord-015306-us58wwmp 4172 10 data datum NNS cord-015306-us58wwmp 4172 11 . . . cord-015306-us58wwmp 4173 1 Results result NNS cord-015306-us58wwmp 4173 2 : : : cord-015306-us58wwmp 4174 1 53.5 53.5 CD cord-015306-us58wwmp 4174 2 % % NN cord-015306-us58wwmp 4174 3 of of IN cord-015306-us58wwmp 4174 4 patients patient NNS cord-015306-us58wwmp 4174 5 reported report VBD cord-015306-us58wwmp 4174 6 health health NN cord-015306-us58wwmp 4174 7 had have VBD cord-015306-us58wwmp 4174 8 interfered interfere VBN cord-015306-us58wwmp 4174 9 with with IN cord-015306-us58wwmp 4174 10 their -PRON- PRP$ cord-015306-us58wwmp 4174 11 social social JJ cord-015306-us58wwmp 4174 12 activities activity NNS cord-015306-us58wwmp 4174 13 demonstrating demonstrate VBG cord-015306-us58wwmp 4174 14 a a DT cord-015306-us58wwmp 4174 15 strong strong JJ cord-015306-us58wwmp 4174 16 associated associate VBN cord-015306-us58wwmp 4174 17 with with IN cord-015306-us58wwmp 4174 18 risk risk NN cord-015306-us58wwmp 4174 19 towards towards IN cord-015306-us58wwmp 4174 20 All all DT cord-015306-us58wwmp 4174 21 - - HYPH cord-015306-us58wwmp 4174 22 Cause cause NN cord-015306-us58wwmp 4174 23 ( ( -LRB- cord-015306-us58wwmp 4174 24 sp=1.33 sp=1.33 NNP cord-015306-us58wwmp 4174 25 ) ) -RRB- cord-015306-us58wwmp 4174 26 and and CC cord-015306-us58wwmp 4174 27 Cause cause NN cord-015306-us58wwmp 4174 28 - - HYPH cord-015306-us58wwmp 4174 29 Specific Specific NNP cord-015306-us58wwmp 4174 30 Mortality mortality NN cord-015306-us58wwmp 4174 31 including include VBG cord-015306-us58wwmp 4174 32 cardiac cardiac JJ cord-015306-us58wwmp 4174 33 diseases disease NNS cord-015306-us58wwmp 4174 34 ( ( -LRB- cord-015306-us58wwmp 4174 35 sp=1.28 sp=1.28 NNP cord-015306-us58wwmp 4174 36 ) ) -RRB- cord-015306-us58wwmp 4174 37 . . . cord-015306-us58wwmp 4175 1 These these DT cord-015306-us58wwmp 4175 2 patients patient NNS cord-015306-us58wwmp 4175 3 had have VBD cord-015306-us58wwmp 4175 4 a a DT cord-015306-us58wwmp 4175 5 greater great JJR cord-015306-us58wwmp 4175 6 risk risk NN cord-015306-us58wwmp 4175 7 of of IN cord-015306-us58wwmp 4175 8 withdrawing withdraw VBG cord-015306-us58wwmp 4175 9 ( ( -LRB- cord-015306-us58wwmp 4175 10 sp=1.67 sp=1.67 NNP cord-015306-us58wwmp 4175 11 ) ) -RRB- cord-015306-us58wwmp 4175 12 from from IN cord-015306-us58wwmp 4175 13 treatment treatment NN cord-015306-us58wwmp 4175 14 , , , cord-015306-us58wwmp 4175 15 non non JJ cord-015306-us58wwmp 4175 16 - - JJ cord-015306-us58wwmp 4175 17 adherence adherence NN cord-015306-us58wwmp 4175 18 to to IN cord-015306-us58wwmp 4175 19 Phosphorus Phosphorus NNP cord-015306-us58wwmp 4175 20 ( ( -LRB- cord-015306-us58wwmp 4175 21 sp=1.06 sp=1.06 NNP cord-015306-us58wwmp 4175 22 ) ) -RRB- cord-015306-us58wwmp 4175 23 greater great JJR cord-015306-us58wwmp 4175 24 than than IN cord-015306-us58wwmp 4175 25 7.5 7.5 CD cord-015306-us58wwmp 4175 26 mg mg NNP cord-015306-us58wwmp 4175 27 / / SYM cord-015306-us58wwmp 4175 28 dL dl NN cord-015306-us58wwmp 4175 29 and and CC cord-015306-us58wwmp 4175 30 increased increase VBN cord-015306-us58wwmp 4175 31 risk risk NN cord-015306-us58wwmp 4175 32 towards towards IN cord-015306-us58wwmp 4175 33 an an DT cord-015306-us58wwmp 4175 34 albumin albumin NN cord-015306-us58wwmp 4175 35 of of IN cord-015306-us58wwmp 4175 36 less less JJR cord-015306-us58wwmp 4175 37 than than IN cord-015306-us58wwmp 4175 38 3.5 3.5 CD cord-015306-us58wwmp 4175 39 g g NN cord-015306-us58wwmp 4175 40 / / SYM cord-015306-us58wwmp 4175 41 dL dl NN cord-015306-us58wwmp 4175 42 ( ( -LRB- cord-015306-us58wwmp 4175 43 sp=1.23 sp=1.23 NNP cord-015306-us58wwmp 4175 44 ) ) -RRB- cord-015306-us58wwmp 4175 45 . . . cord-015306-us58wwmp 4176 1 Patients patient NNS cord-015306-us58wwmp 4176 2 reporting report VBG cord-015306-us58wwmp 4176 3 dissatisfied dissatisfy VBN cord-015306-us58wwmp 4176 4 with with IN cord-015306-us58wwmp 4176 5 family family NN cord-015306-us58wwmp 4176 6 support support NN cord-015306-us58wwmp 4176 7 ( ( -LRB- cord-015306-us58wwmp 4176 8 12.0 12.0 CD cord-015306-us58wwmp 4176 9 % % NN cord-015306-us58wwmp 4176 10 ) ) -RRB- cord-015306-us58wwmp 4176 11 were be VBD cord-015306-us58wwmp 4176 12 at at IN cord-015306-us58wwmp 4176 13 highest high JJS cord-015306-us58wwmp 4176 14 risk risk NN cord-015306-us58wwmp 4176 15 to to IN cord-015306-us58wwmp 4176 16 non non JJ cord-015306-us58wwmp 4176 17 - - JJ cord-015306-us58wwmp 4176 18 adherence adherence NN cord-015306-us58wwmp 4176 19 to to IN cord-015306-us58wwmp 4176 20 intra intra JJ cord-015306-us58wwmp 4176 21 - - JJ cord-015306-us58wwmp 4176 22 dialytic dialytic JJ cord-015306-us58wwmp 4176 23 weight weight NN cord-015306-us58wwmp 4176 24 gain gain NN cord-015306-us58wwmp 4176 25 ( ( -LRB- cord-015306-us58wwmp 4176 26 sp=1.27 sp=1.27 NNP cord-015306-us58wwmp 4176 27 ) ) -RRB- cord-015306-us58wwmp 4176 28 , , , cord-015306-us58wwmp 4176 29 shortening shorten VBG cord-015306-us58wwmp 4176 30 the the DT cord-015306-us58wwmp 4176 31 dialysis dialysis NN cord-015306-us58wwmp 4176 32 session session NN cord-015306-us58wwmp 4176 33 ( ( -LRB- cord-015306-us58wwmp 4176 34 sp=1.21 sp=1.21 NNS cord-015306-us58wwmp 4176 35 ) ) -RRB- cord-015306-us58wwmp 4176 36 and and CC cord-015306-us58wwmp 4176 37 increased increase VBN cord-015306-us58wwmp 4176 38 risk risk NN cord-015306-us58wwmp 4176 39 of of IN cord-015306-us58wwmp 4176 40 Potassium potassium NN cord-015306-us58wwmp 4176 41 level level NN cord-015306-us58wwmp 4176 42 greater great JJR cord-015306-us58wwmp 4176 43 than than IN cord-015306-us58wwmp 4176 44 6 6 CD cord-015306-us58wwmp 4176 45 mEq mEq NNS cord-015306-us58wwmp 4176 46 / / SYM cord-015306-us58wwmp 4176 47 L L NNP cord-015306-us58wwmp 4176 48 ( ( -LRB- cord-015306-us58wwmp 4176 49 sp=1.14 sp=1.14 NNP cord-015306-us58wwmp 4176 50 ) ) -RRB- cord-015306-us58wwmp 4176 51 . . . cord-015306-us58wwmp 4177 1 However however RB cord-015306-us58wwmp 4177 2 , , , cord-015306-us58wwmp 4177 3 patients patient NNS cord-015306-us58wwmp 4177 4 reporting report VBG cord-015306-us58wwmp 4177 5 dissatisfied dissatisfy VBN cord-015306-us58wwmp 4177 6 with with IN cord-015306-us58wwmp 4177 7 staff staff NN cord-015306-us58wwmp 4177 8 support support NN cord-015306-us58wwmp 4177 9 ( ( -LRB- cord-015306-us58wwmp 4177 10 14.1 14.1 CD cord-015306-us58wwmp 4177 11 % % NN cord-015306-us58wwmp 4177 12 ) ) -RRB- cord-015306-us58wwmp 4177 13 revealed reveal VBD cord-015306-us58wwmp 4177 14 a a DT cord-015306-us58wwmp 4177 15 higher high JJR cord-015306-us58wwmp 4177 16 risk risk NN cord-015306-us58wwmp 4177 17 of of IN cord-015306-us58wwmp 4177 18 decreased decreased JJ cord-015306-us58wwmp 4177 19 physical physical JJ cord-015306-us58wwmp 4177 20 QoL qol NN cord-015306-us58wwmp 4177 21 ( ( -LRB- cord-015306-us58wwmp 4177 22 sp=0.76 sp=0.76 NNP cord-015306-us58wwmp 4177 23 ) ) -RRB- cord-015306-us58wwmp 4177 24 . . . cord-015306-us58wwmp 4178 1 Conclusion conclusion NN cord-015306-us58wwmp 4178 2 : : : cord-015306-us58wwmp 4179 1 This this DT cord-015306-us58wwmp 4179 2 study study NN cord-015306-us58wwmp 4179 3 demonstrated demonstrate VBD cord-015306-us58wwmp 4179 4 that that IN cord-015306-us58wwmp 4179 5 physical physical JJ cord-015306-us58wwmp 4179 6 QoL qol NN cord-015306-us58wwmp 4179 7 was be VBD cord-015306-us58wwmp 4179 8 not not RB cord-015306-us58wwmp 4179 9 only only RB cord-015306-us58wwmp 4179 10 affected affect VBN cord-015306-us58wwmp 4179 11 by by IN cord-015306-us58wwmp 4179 12 medications medication NNS cord-015306-us58wwmp 4179 13 and and CC cord-015306-us58wwmp 4179 14 other other JJ cord-015306-us58wwmp 4179 15 laboratory laboratory NN cord-015306-us58wwmp 4179 16 work work NN cord-015306-us58wwmp 4179 17 - - HYPH cord-015306-us58wwmp 4179 18 ups up NNS cord-015306-us58wwmp 4179 19 but but CC cord-015306-us58wwmp 4179 20 also also RB cord-015306-us58wwmp 4179 21 with with IN cord-015306-us58wwmp 4179 22 additional additional JJ cord-015306-us58wwmp 4179 23 psychosocial psychosocial JJ cord-015306-us58wwmp 4179 24 support support NN cord-015306-us58wwmp 4179 25 . . . cord-015306-us58wwmp 4180 1 The the DT cord-015306-us58wwmp 4180 2 study study NN cord-015306-us58wwmp 4180 3 led lead VBD cord-015306-us58wwmp 4180 4 to to IN cord-015306-us58wwmp 4180 5 the the DT cord-015306-us58wwmp 4180 6 development development NN cord-015306-us58wwmp 4180 7 of of IN cord-015306-us58wwmp 4180 8 programs program NNS cord-015306-us58wwmp 4180 9 empowering empower VBG cord-015306-us58wwmp 4180 10 patients patient NNS cord-015306-us58wwmp 4180 11 and and CC cord-015306-us58wwmp 4180 12 families family NNS cord-015306-us58wwmp 4180 13 to to TO cord-015306-us58wwmp 4180 14 participate participate VB cord-015306-us58wwmp 4180 15 in in IN cord-015306-us58wwmp 4180 16 their -PRON- PRP$ cord-015306-us58wwmp 4180 17 treatment treatment NN cord-015306-us58wwmp 4180 18 plans plan NNS cord-015306-us58wwmp 4180 19 . . . cord-015306-us58wwmp 4181 1 The the DT cord-015306-us58wwmp 4181 2 program program NN cord-015306-us58wwmp 4181 3 includes include VBZ cord-015306-us58wwmp 4181 4 various various JJ cord-015306-us58wwmp 4181 5 counselling counselling NN cord-015306-us58wwmp 4181 6 approaches approach NNS cord-015306-us58wwmp 4181 7 directed direct VBN cord-015306-us58wwmp 4181 8 to to IN cord-015306-us58wwmp 4181 9 patient patient NN cord-015306-us58wwmp 4181 10 , , , cord-015306-us58wwmp 4181 11 families family NNS cord-015306-us58wwmp 4181 12 , , , cord-015306-us58wwmp 4181 13 and and CC cord-015306-us58wwmp 4181 14 health health NN cord-015306-us58wwmp 4181 15 team team NN cord-015306-us58wwmp 4181 16 . . . cord-015306-us58wwmp 4182 1 Objective objective NN cord-015306-us58wwmp 4182 2 : : : cord-015306-us58wwmp 4183 1 The the DT cord-015306-us58wwmp 4183 2 aim aim NN cord-015306-us58wwmp 4183 3 of of IN cord-015306-us58wwmp 4183 4 the the DT cord-015306-us58wwmp 4183 5 study study NN cord-015306-us58wwmp 4183 6 was be VBD cord-015306-us58wwmp 4183 7 to to TO cord-015306-us58wwmp 4183 8 analyze analyze VB cord-015306-us58wwmp 4183 9 health health NN cord-015306-us58wwmp 4183 10 - - HYPH cord-015306-us58wwmp 4183 11 related relate VBN cord-015306-us58wwmp 4183 12 quality quality NN cord-015306-us58wwmp 4183 13 of of IN cord-015306-us58wwmp 4183 14 live live JJ cord-015306-us58wwmp 4183 15 ( ( -LRB- cord-015306-us58wwmp 4183 16 HRQoL HRQoL NNP cord-015306-us58wwmp 4183 17 ) ) -RRB- cord-015306-us58wwmp 4183 18 in in IN cord-015306-us58wwmp 4183 19 children child NNS cord-015306-us58wwmp 4183 20 with with IN cord-015306-us58wwmp 4183 21 chronic chronic JJ cord-015306-us58wwmp 4183 22 kidney kidney NN cord-015306-us58wwmp 4183 23 disease disease NN cord-015306-us58wwmp 4183 24 ( ( -LRB- cord-015306-us58wwmp 4183 25 CKD CKD NNP cord-015306-us58wwmp 4183 26 ) ) -RRB- cord-015306-us58wwmp 4183 27 dependent dependent JJ cord-015306-us58wwmp 4183 28 on on IN cord-015306-us58wwmp 4183 29 the the DT cord-015306-us58wwmp 4183 30 CKD CKD NNP cord-015306-us58wwmp 4183 31 stage stage NN cord-015306-us58wwmp 4183 32 , , , cord-015306-us58wwmp 4183 33 treatment treatment NN cord-015306-us58wwmp 4183 34 modality modality NN cord-015306-us58wwmp 4183 35 and and CC cord-015306-us58wwmp 4183 36 selected select VBN cord-015306-us58wwmp 4183 37 social social JJ cord-015306-us58wwmp 4183 38 life life NN cord-015306-us58wwmp 4183 39 elements element NNS cord-015306-us58wwmp 4183 40 in in IN cord-015306-us58wwmp 4183 41 families family NNS cord-015306-us58wwmp 4183 42 of of IN cord-015306-us58wwmp 4183 43 the the DT cord-015306-us58wwmp 4183 44 patients patient NNS cord-015306-us58wwmp 4183 45 . . . cord-015306-us58wwmp 4184 1 Furthermore furthermore RB cord-015306-us58wwmp 4184 2 , , , cord-015306-us58wwmp 4184 3 potential potential JJ cord-015306-us58wwmp 4184 4 differences difference NNS cord-015306-us58wwmp 4184 5 between between IN cord-015306-us58wwmp 4184 6 self self NN cord-015306-us58wwmp 4184 7 - - HYPH cord-015306-us58wwmp 4184 8 and and CC cord-015306-us58wwmp 4184 9 parent parent NN cord-015306-us58wwmp 4184 10 / / SYM cord-015306-us58wwmp 4184 11 proxy proxy NN cord-015306-us58wwmp 4184 12 reports report NNS cord-015306-us58wwmp 4184 13 and and CC cord-015306-us58wwmp 4184 14 the the DT cord-015306-us58wwmp 4184 15 factors factor NNS cord-015306-us58wwmp 4184 16 influencing influence VBG cord-015306-us58wwmp 4184 17 them -PRON- PRP cord-015306-us58wwmp 4184 18 were be VBD cord-015306-us58wwmp 4184 19 assessed assess VBN cord-015306-us58wwmp 4184 20 . . . cord-015306-us58wwmp 4185 1 Methods method NNS cord-015306-us58wwmp 4185 2 : : : cord-015306-us58wwmp 4185 3 203 203 CD cord-015306-us58wwmp 4185 4 CKD CKD NNP cord-015306-us58wwmp 4185 5 children child NNS cord-015306-us58wwmp 4185 6 ( ( -LRB- cord-015306-us58wwmp 4185 7 on on IN cord-015306-us58wwmp 4185 8 hemodialysis hemodialysis NN cord-015306-us58wwmp 4185 9 - - HYPH cord-015306-us58wwmp 4185 10 HD hd NN cord-015306-us58wwmp 4185 11 , , , cord-015306-us58wwmp 4185 12 peritoneal peritoneal JJ cord-015306-us58wwmp 4185 13 dialysis dialysis NN cord-015306-us58wwmp 4185 14 - - HYPH cord-015306-us58wwmp 4185 15 PD pd NN cord-015306-us58wwmp 4185 16 and and CC cord-015306-us58wwmp 4185 17 conservative conservative JJ cord-015306-us58wwmp 4185 18 treatment treatment NN cord-015306-us58wwmp 4185 19 - - HYPH cord-015306-us58wwmp 4185 20 CT CT NNP cord-015306-us58wwmp 4185 21 ) ) -RRB- cord-015306-us58wwmp 4185 22 and and CC cord-015306-us58wwmp 4185 23 their -PRON- PRP$ cord-015306-us58wwmp 4185 24 388 388 CD cord-015306-us58wwmp 4185 25 parentproxies parentproxie NNS cord-015306-us58wwmp 4185 26 were be VBD cord-015306-us58wwmp 4185 27 enrolled enrol VBN cord-015306-us58wwmp 4185 28 into into IN cord-015306-us58wwmp 4185 29 a a DT cord-015306-us58wwmp 4185 30 cross cross JJ cord-015306-us58wwmp 4185 31 - - JJ cord-015306-us58wwmp 4185 32 sectional sectional JJ cord-015306-us58wwmp 4185 33 national national JJ cord-015306-us58wwmp 4185 34 study study NN cord-015306-us58wwmp 4185 35 . . . cord-015306-us58wwmp 4186 1 A a DT cord-015306-us58wwmp 4186 2 semistructured semistructured JJ cord-015306-us58wwmp 4186 3 interview interview NN cord-015306-us58wwmp 4186 4 form form NN cord-015306-us58wwmp 4186 5 was be VBD cord-015306-us58wwmp 4186 6 used use VBN cord-015306-us58wwmp 4186 7 to to TO cord-015306-us58wwmp 4186 8 determine determine VB cord-015306-us58wwmp 4186 9 the the DT cord-015306-us58wwmp 4186 10 demographic demographic JJ cord-015306-us58wwmp 4186 11 and and CC cord-015306-us58wwmp 4186 12 social social JJ cord-015306-us58wwmp 4186 13 characteristics characteristic NNS cord-015306-us58wwmp 4186 14 of of IN cord-015306-us58wwmp 4186 15 the the DT cord-015306-us58wwmp 4186 16 participants participant NNS cord-015306-us58wwmp 4186 17 . . . cord-015306-us58wwmp 4187 1 We -PRON- PRP cord-015306-us58wwmp 4187 2 used use VBD cord-015306-us58wwmp 4187 3 the the DT cord-015306-us58wwmp 4187 4 Pediatric Pediatric NNP cord-015306-us58wwmp 4187 5 Quality Quality NNP cord-015306-us58wwmp 4187 6 of of IN cord-015306-us58wwmp 4187 7 Life Life NNP cord-015306-us58wwmp 4187 8 Inventory Inventory NNP cord-015306-us58wwmp 4187 9 ( ( -LRB- cord-015306-us58wwmp 4187 10 PedsQL PedsQL NNP cord-015306-us58wwmp 4187 11 ) ) -RRB- cord-015306-us58wwmp 4187 12 4.0 4.0 CD cord-015306-us58wwmp 4187 13 Generic Generic NNP cord-015306-us58wwmp 4187 14 Core Core NNP cord-015306-us58wwmp 4187 15 Scales Scales NNP cord-015306-us58wwmp 4187 16 to to TO cord-015306-us58wwmp 4187 17 assess assess VB cord-015306-us58wwmp 4187 18 the the DT cord-015306-us58wwmp 4187 19 HRQoL HRQoL NNP cord-015306-us58wwmp 4187 20 in in IN cord-015306-us58wwmp 4187 21 children child NNS cord-015306-us58wwmp 4187 22 . . . cord-015306-us58wwmp 4188 1 Results result NNS cord-015306-us58wwmp 4188 2 : : : cord-015306-us58wwmp 4189 1 HRQoL HRQoL NNP cord-015306-us58wwmp 4189 2 scores score NNS cord-015306-us58wwmp 4189 3 for for IN cord-015306-us58wwmp 4189 4 all all DT cord-015306-us58wwmp 4189 5 CKD CKD NNP cord-015306-us58wwmp 4189 6 groups group NNS cord-015306-us58wwmp 4189 7 were be VBD cord-015306-us58wwmp 4189 8 significantly significantly RB cord-015306-us58wwmp 4189 9 lower low JJR cord-015306-us58wwmp 4189 10 in in IN cord-015306-us58wwmp 4189 11 all all DT cord-015306-us58wwmp 4189 12 domains domain NNS cord-015306-us58wwmp 4189 13 compared compare VBN cord-015306-us58wwmp 4189 14 with with IN cord-015306-us58wwmp 4189 15 population population NN cord-015306-us58wwmp 4189 16 norms norm NNS cord-015306-us58wwmp 4189 17 , , , cord-015306-us58wwmp 4189 18 the the DT cord-015306-us58wwmp 4189 19 lowest low JJS cord-015306-us58wwmp 4189 20 one one NN cord-015306-us58wwmp 4189 21 being be VBG cord-015306-us58wwmp 4189 22 in in IN cord-015306-us58wwmp 4189 23 the the DT cord-015306-us58wwmp 4189 24 HD hd NN cord-015306-us58wwmp 4189 25 group group NN cord-015306-us58wwmp 4189 26 . . . cord-015306-us58wwmp 4190 1 In in IN cord-015306-us58wwmp 4190 2 CT CT NNP cord-015306-us58wwmp 4190 3 children child NNS cord-015306-us58wwmp 4190 4 , , , cord-015306-us58wwmp 4190 5 HRQoL HRQoL NNP cord-015306-us58wwmp 4190 6 did do VBD cord-015306-us58wwmp 4190 7 not not RB cord-015306-us58wwmp 4190 8 depend depend VB cord-015306-us58wwmp 4190 9 on on IN cord-015306-us58wwmp 4190 10 the the DT cord-015306-us58wwmp 4190 11 CKD CKD NNP cord-015306-us58wwmp 4190 12 stage stage NN cord-015306-us58wwmp 4190 13 . . . cord-015306-us58wwmp 4191 1 Children child NNS cord-015306-us58wwmp 4191 2 with with IN cord-015306-us58wwmp 4191 3 CKD CKD NNP cord-015306-us58wwmp 4191 4 reported report VBD cord-015306-us58wwmp 4191 5 problems problem NNS cord-015306-us58wwmp 4191 6 with with IN cord-015306-us58wwmp 4191 7 education education NN cord-015306-us58wwmp 4191 8 and and CC cord-015306-us58wwmp 4191 9 emotional emotional JJ cord-015306-us58wwmp 4191 10 functioning functioning NN cord-015306-us58wwmp 4191 11 . . . cord-015306-us58wwmp 4192 1 Both both DT cord-015306-us58wwmp 4192 2 parents parent NNS cord-015306-us58wwmp 4192 3 assessed assess VBD cord-015306-us58wwmp 4192 4 the the DT cord-015306-us58wwmp 4192 5 HRQoL HRQoL NNP cord-015306-us58wwmp 4192 6 of of IN cord-015306-us58wwmp 4192 7 their -PRON- PRP$ cord-015306-us58wwmp 4192 8 children child NNS cord-015306-us58wwmp 4192 9 differently differently RB cord-015306-us58wwmp 4192 10 depending depend VBG cord-015306-us58wwmp 4192 11 on on IN cord-015306-us58wwmp 4192 12 their -PRON- PRP$ cord-015306-us58wwmp 4192 13 involvement involvement NN cord-015306-us58wwmp 4192 14 in in IN cord-015306-us58wwmp 4192 15 the the DT cord-015306-us58wwmp 4192 16 care care NN cord-015306-us58wwmp 4192 17 . . . cord-015306-us58wwmp 4193 1 There there EX cord-015306-us58wwmp 4193 2 are be VBP cord-015306-us58wwmp 4193 3 differences difference NNS cord-015306-us58wwmp 4193 4 between between IN cord-015306-us58wwmp 4193 5 the the DT cord-015306-us58wwmp 4193 6 HRQoL HRQoL NNP cord-015306-us58wwmp 4193 7 scores score NNS cord-015306-us58wwmp 4193 8 of of IN cord-015306-us58wwmp 4193 9 the the DT cord-015306-us58wwmp 4193 10 children child NNS cord-015306-us58wwmp 4193 11 and and CC cord-015306-us58wwmp 4193 12 their -PRON- PRP$ cord-015306-us58wwmp 4193 13 parents parent NNS cord-015306-us58wwmp 4193 14 . . . cord-015306-us58wwmp 4194 1 Conclusion conclusion NN cord-015306-us58wwmp 4194 2 : : : cord-015306-us58wwmp 4195 1 The the DT cord-015306-us58wwmp 4195 2 HRQoL HRQoL NNP cord-015306-us58wwmp 4195 3 in in IN cord-015306-us58wwmp 4195 4 children child NNS cord-015306-us58wwmp 4195 5 with with IN cord-015306-us58wwmp 4195 6 CKD CKD NNP cord-015306-us58wwmp 4195 7 is be VBZ cord-015306-us58wwmp 4195 8 lower low JJR cord-015306-us58wwmp 4195 9 than than IN cord-015306-us58wwmp 4195 10 in in IN cord-015306-us58wwmp 4195 11 healthy healthy JJ cord-015306-us58wwmp 4195 12 children child NNS cord-015306-us58wwmp 4195 13 . . . cord-015306-us58wwmp 4196 1 This this DT cord-015306-us58wwmp 4196 2 is be VBZ cord-015306-us58wwmp 4196 3 already already RB cord-015306-us58wwmp 4196 4 observed observe VBN cord-015306-us58wwmp 4196 5 in in IN cord-015306-us58wwmp 4196 6 the the DT cord-015306-us58wwmp 4196 7 early early JJ cord-015306-us58wwmp 4196 8 stages stage NNS cord-015306-us58wwmp 4196 9 of of IN cord-015306-us58wwmp 4196 10 the the DT cord-015306-us58wwmp 4196 11 disease disease NN cord-015306-us58wwmp 4196 12 . . . cord-015306-us58wwmp 4197 1 The the DT cord-015306-us58wwmp 4197 2 disease disease NN cord-015306-us58wwmp 4197 3 itself -PRON- PRP cord-015306-us58wwmp 4197 4 influences influence VBZ cord-015306-us58wwmp 4197 5 the the DT cord-015306-us58wwmp 4197 6 child child NN cord-015306-us58wwmp 4197 7 's 's POS cord-015306-us58wwmp 4197 8 mental mental JJ cord-015306-us58wwmp 4197 9 state state NN cord-015306-us58wwmp 4197 10 . . . cord-015306-us58wwmp 4198 1 Children child NNS cord-015306-us58wwmp 4198 2 on on IN cord-015306-us58wwmp 4198 3 HD HD NNP cord-015306-us58wwmp 4198 4 require require VBP cord-015306-us58wwmp 4198 5 special special JJ cord-015306-us58wwmp 4198 6 support support NN cord-015306-us58wwmp 4198 7 on on IN cord-015306-us58wwmp 4198 8 account account NN cord-015306-us58wwmp 4198 9 of of IN cord-015306-us58wwmp 4198 10 the the DT cord-015306-us58wwmp 4198 11 lowest low JJS cord-015306-us58wwmp 4198 12 demonstrated demonstrate VBN cord-015306-us58wwmp 4198 13 overall overall JJ cord-015306-us58wwmp 4198 14 HRQoL. HRQoL. NNP cord-015306-us58wwmp 4198 15 Children Children NNP cord-015306-us58wwmp 4198 16 's 's POS cord-015306-us58wwmp 4198 17 lower low JJR cord-015306-us58wwmp 4198 18 rating rating NN cord-015306-us58wwmp 4198 19 of of IN cord-015306-us58wwmp 4198 20 the the DT cord-015306-us58wwmp 4198 21 quality quality NN cord-015306-us58wwmp 4198 22 of of IN cord-015306-us58wwmp 4198 23 life life NN cord-015306-us58wwmp 4198 24 observed observe VBN cord-015306-us58wwmp 4198 25 by by IN cord-015306-us58wwmp 4198 26 their -PRON- PRP$ cord-015306-us58wwmp 4198 27 parents parent NNS cord-015306-us58wwmp 4198 28 may may MD cord-015306-us58wwmp 4198 29 render render VB cord-015306-us58wwmp 4198 30 the the DT cord-015306-us58wwmp 4198 31 patients patient NNS cord-015306-us58wwmp 4198 32 unmotivated unmotivated JJ cord-015306-us58wwmp 4198 33 and and CC cord-015306-us58wwmp 4198 34 adversely adversely RB cord-015306-us58wwmp 4198 35 affect affect VB cord-015306-us58wwmp 4198 36 their -PRON- PRP$ cord-015306-us58wwmp 4198 37 adjustment adjustment NN cord-015306-us58wwmp 4198 38 to to IN cord-015306-us58wwmp 4198 39 life life NN cord-015306-us58wwmp 4198 40 in in IN cord-015306-us58wwmp 4198 41 later later JJ cord-015306-us58wwmp 4198 42 years year NNS cord-015306-us58wwmp 4198 43 . . . cord-015306-us58wwmp 4199 1 It -PRON- PRP cord-015306-us58wwmp 4199 2 may may MD cord-015306-us58wwmp 4199 3 also also RB cord-015306-us58wwmp 4199 4 create create VB cord-015306-us58wwmp 4199 5 conflicts conflict NNS cord-015306-us58wwmp 4199 6 between between IN cord-015306-us58wwmp 4199 7 the the DT cord-015306-us58wwmp 4199 8 parents parent NNS cord-015306-us58wwmp 4199 9 and and CC cord-015306-us58wwmp 4199 10 the the DT cord-015306-us58wwmp 4199 11 children child NNS cord-015306-us58wwmp 4199 12 . . . cord-015306-us58wwmp 4200 1 Objective objective NN cord-015306-us58wwmp 4200 2 : : : cord-015306-us58wwmp 4201 1 Chronic chronic JJ cord-015306-us58wwmp 4201 2 medical medical JJ cord-015306-us58wwmp 4201 3 illness illness NN cord-015306-us58wwmp 4201 4 is be VBZ cord-015306-us58wwmp 4201 5 a a DT cord-015306-us58wwmp 4201 6 significant significant JJ cord-015306-us58wwmp 4201 7 risk risk NN cord-015306-us58wwmp 4201 8 factor factor NN cord-015306-us58wwmp 4201 9 for for IN cord-015306-us58wwmp 4201 10 the the DT cord-015306-us58wwmp 4201 11 development development NN cord-015306-us58wwmp 4201 12 of of IN cord-015306-us58wwmp 4201 13 psychiatric psychiatric JJ cord-015306-us58wwmp 4201 14 disorders disorder NNS cord-015306-us58wwmp 4201 15 . . . cord-015306-us58wwmp 4202 1 The the DT cord-015306-us58wwmp 4202 2 aims aim NNS cord-015306-us58wwmp 4202 3 of of IN cord-015306-us58wwmp 4202 4 the the DT cord-015306-us58wwmp 4202 5 study study NN cord-015306-us58wwmp 4202 6 were be VBD cord-015306-us58wwmp 4202 7 : : : cord-015306-us58wwmp 4202 8 to to TO cord-015306-us58wwmp 4202 9 investigate investigate VB cord-015306-us58wwmp 4202 10 the the DT cord-015306-us58wwmp 4202 11 level level NN cord-015306-us58wwmp 4202 12 of of IN cord-015306-us58wwmp 4202 13 anxiety anxiety NN cord-015306-us58wwmp 4202 14 in in IN cord-015306-us58wwmp 4202 15 children child NNS cord-015306-us58wwmp 4202 16 with with IN cord-015306-us58wwmp 4202 17 chronic chronic JJ cord-015306-us58wwmp 4202 18 kidney kidney NN cord-015306-us58wwmp 4202 19 disease disease NN cord-015306-us58wwmp 4202 20 ( ( -LRB- cord-015306-us58wwmp 4202 21 CKD CKD NNP cord-015306-us58wwmp 4202 22 ) ) -RRB- cord-015306-us58wwmp 4202 23 and and CC cord-015306-us58wwmp 4202 24 to to TO cord-015306-us58wwmp 4202 25 identify identify VB cord-015306-us58wwmp 4202 26 factors factor NNS cord-015306-us58wwmp 4202 27 associated associate VBN cord-015306-us58wwmp 4202 28 with with IN cord-015306-us58wwmp 4202 29 the the DT cord-015306-us58wwmp 4202 30 presence presence NN cord-015306-us58wwmp 4202 31 of of IN cord-015306-us58wwmp 4202 32 that that DT cord-015306-us58wwmp 4202 33 emotional emotional JJ cord-015306-us58wwmp 4202 34 problem problem NN cord-015306-us58wwmp 4202 35 . . . cord-015306-us58wwmp 4203 1 Methods method NNS cord-015306-us58wwmp 4203 2 : : : cord-015306-us58wwmp 4203 3 CKD CKD NNP cord-015306-us58wwmp 4203 4 children child NNS cord-015306-us58wwmp 4203 5 on on IN cord-015306-us58wwmp 4203 6 hemodialysis hemodialysis NN cord-015306-us58wwmp 4203 7 ( ( -LRB- cord-015306-us58wwmp 4203 8 HD HD NNP cord-015306-us58wwmp 4203 9 , , , cord-015306-us58wwmp 4203 10 n=22 n=22 NNP cord-015306-us58wwmp 4203 11 ) ) -RRB- cord-015306-us58wwmp 4203 12 , , , cord-015306-us58wwmp 4203 13 peritoneal peritoneal JJ cord-015306-us58wwmp 4203 14 dialysis dialysis NN cord-015306-us58wwmp 4203 15 ( ( -LRB- cord-015306-us58wwmp 4203 16 PD PD NNP cord-015306-us58wwmp 4203 17 , , , cord-015306-us58wwmp 4203 18 n=20 n=20 NN cord-015306-us58wwmp 4203 19 , , , cord-015306-us58wwmp 4203 20 ) ) -RRB- cord-015306-us58wwmp 4203 21 and and CC cord-015306-us58wwmp 4203 22 on on IN cord-015306-us58wwmp 4203 23 conservative conservative JJ cord-015306-us58wwmp 4203 24 treatment treatment NN cord-015306-us58wwmp 4203 25 ( ( -LRB- cord-015306-us58wwmp 4203 26 CT CT NNP cord-015306-us58wwmp 4203 27 , , , cord-015306-us58wwmp 4203 28 n=95 n=95 NNP cord-015306-us58wwmp 4203 29 ) ) -RRB- cord-015306-us58wwmp 4203 30 , , , cord-015306-us58wwmp 4203 31 and and CC cord-015306-us58wwmp 4203 32 healthy healthy JJ cord-015306-us58wwmp 4203 33 subjects subject NNS cord-015306-us58wwmp 4203 34 ( ( -LRB- cord-015306-us58wwmp 4203 35 n=100 n=100 CD cord-015306-us58wwmp 4203 36 ) ) -RRB- cord-015306-us58wwmp 4203 37 were be VBD cord-015306-us58wwmp 4203 38 enrolled enrol VBN cord-015306-us58wwmp 4203 39 in in IN cord-015306-us58wwmp 4203 40 the the DT cord-015306-us58wwmp 4203 41 study study NN cord-015306-us58wwmp 4203 42 . . . cord-015306-us58wwmp 4204 1 We -PRON- PRP cord-015306-us58wwmp 4204 2 used use VBD cord-015306-us58wwmp 4204 3 State state NN cord-015306-us58wwmp 4204 4 - - HYPH cord-015306-us58wwmp 4204 5 Trait Trait NNP cord-015306-us58wwmp 4204 6 Anxiety Anxiety NNP cord-015306-us58wwmp 4204 7 Inventory inventory NN cord-015306-us58wwmp 4204 8 ( ( -LRB- cord-015306-us58wwmp 4204 9 STAI STAI NNP cord-015306-us58wwmp 4204 10 ) ) -RRB- cord-015306-us58wwmp 4204 11 for for IN cord-015306-us58wwmp 4204 12 adolescents adolescent NNS cord-015306-us58wwmp 4204 13 and and CC cord-015306-us58wwmp 4204 14 STAI STAI NNP cord-015306-us58wwmp 4204 15 - - HYPH cord-015306-us58wwmp 4204 16 C C NNP cord-015306-us58wwmp 4204 17 for for IN cord-015306-us58wwmp 4204 18 children child NNS cord-015306-us58wwmp 4204 19 . . . cord-015306-us58wwmp 4205 1 Socio socio JJ cord-015306-us58wwmp 4205 2 - - HYPH cord-015306-us58wwmp 4205 3 demographic demographic JJ cord-015306-us58wwmp 4205 4 and and CC cord-015306-us58wwmp 4205 5 physical physical JJ cord-015306-us58wwmp 4205 6 factors factor NNS cord-015306-us58wwmp 4205 7 were be VBD cord-015306-us58wwmp 4205 8 assessed assess VBN cord-015306-us58wwmp 4205 9 . . . cord-015306-us58wwmp 4206 1 Results result NNS cord-015306-us58wwmp 4206 2 : : : cord-015306-us58wwmp 4207 1 There there EX cord-015306-us58wwmp 4207 2 was be VBD cord-015306-us58wwmp 4207 3 a a DT cord-015306-us58wwmp 4207 4 significantly significantly RB cord-015306-us58wwmp 4207 5 higher high JJR cord-015306-us58wwmp 4207 6 level level NN cord-015306-us58wwmp 4207 7 of of IN cord-015306-us58wwmp 4207 8 anxiety anxiety NN cord-015306-us58wwmp 4207 9 - - HYPH cord-015306-us58wwmp 4207 10 state state NN cord-015306-us58wwmp 4207 11 among among IN cord-015306-us58wwmp 4207 12 HD HD NNP cord-015306-us58wwmp 4207 13 children child NNS cord-015306-us58wwmp 4207 14 ( ( -LRB- cord-015306-us58wwmp 4207 15 8 8 CD cord-015306-us58wwmp 4207 16 - - SYM cord-015306-us58wwmp 4207 17 12 12 CD cord-015306-us58wwmp 4207 18 years year NNS cord-015306-us58wwmp 4207 19 ) ) -RRB- cord-015306-us58wwmp 4207 20 compared compare VBN cord-015306-us58wwmp 4207 21 with with IN cord-015306-us58wwmp 4207 22 other other JJ cord-015306-us58wwmp 4207 23 groups group NNS cord-015306-us58wwmp 4207 24 of of IN cord-015306-us58wwmp 4207 25 participants participant NNS cord-015306-us58wwmp 4207 26 of of IN cord-015306-us58wwmp 4207 27 the the DT cord-015306-us58wwmp 4207 28 same same JJ cord-015306-us58wwmp 4207 29 age age NN cord-015306-us58wwmp 4207 30 . . . cord-015306-us58wwmp 4208 1 The the DT cord-015306-us58wwmp 4208 2 level level NN cord-015306-us58wwmp 4208 3 of of IN cord-015306-us58wwmp 4208 4 anxiety anxiety NN cord-015306-us58wwmp 4208 5 among among IN cord-015306-us58wwmp 4208 6 adolescents adolescent NNS cord-015306-us58wwmp 4208 7 ( ( -LRB- cord-015306-us58wwmp 4208 8 13 13 CD cord-015306-us58wwmp 4208 9 - - SYM cord-015306-us58wwmp 4208 10 18 18 CD cord-015306-us58wwmp 4208 11 years year NNS cord-015306-us58wwmp 4208 12 ) ) -RRB- cord-015306-us58wwmp 4208 13 , , , cord-015306-us58wwmp 4208 14 both both DT cord-015306-us58wwmp 4208 15 anxiety anxiety NN cord-015306-us58wwmp 4208 16 - - HYPH cord-015306-us58wwmp 4208 17 state state NN cord-015306-us58wwmp 4208 18 and and CC cord-015306-us58wwmp 4208 19 anxiety anxiety NN cord-015306-us58wwmp 4208 20 - - HYPH cord-015306-us58wwmp 4208 21 trait trait NN cord-015306-us58wwmp 4208 22 , , , cord-015306-us58wwmp 4208 23 was be VBD cord-015306-us58wwmp 4208 24 significantly significantly RB cord-015306-us58wwmp 4208 25 higher high JJR cord-015306-us58wwmp 4208 26 in in IN cord-015306-us58wwmp 4208 27 the the DT cord-015306-us58wwmp 4208 28 HD hd NN cord-015306-us58wwmp 4208 29 group group NN cord-015306-us58wwmp 4208 30 compared compare VBN cord-015306-us58wwmp 4208 31 with with IN cord-015306-us58wwmp 4208 32 other other JJ cord-015306-us58wwmp 4208 33 groups group NNS cord-015306-us58wwmp 4208 34 , , , cord-015306-us58wwmp 4208 35 which which WDT cord-015306-us58wwmp 4208 36 did do VBD cord-015306-us58wwmp 4208 37 not not RB cord-015306-us58wwmp 4208 38 differ differ VB cord-015306-us58wwmp 4208 39 among among IN cord-015306-us58wwmp 4208 40 themselves -PRON- PRP cord-015306-us58wwmp 4208 41 . . . cord-015306-us58wwmp 4209 1 In in IN cord-015306-us58wwmp 4209 2 the the DT cord-015306-us58wwmp 4209 3 HD hd NN cord-015306-us58wwmp 4209 4 adolescents adolescent NNS cord-015306-us58wwmp 4209 5 , , , cord-015306-us58wwmp 4209 6 there there EX cord-015306-us58wwmp 4209 7 was be VBD cord-015306-us58wwmp 4209 8 a a DT cord-015306-us58wwmp 4209 9 correlation correlation NN cord-015306-us58wwmp 4209 10 between between IN cord-015306-us58wwmp 4209 11 the the DT cord-015306-us58wwmp 4209 12 anxiety anxiety NN cord-015306-us58wwmp 4209 13 - - HYPH cord-015306-us58wwmp 4209 14 state state NN cord-015306-us58wwmp 4209 15 and and CC cord-015306-us58wwmp 4209 16 the the DT cord-015306-us58wwmp 4209 17 duration duration NN cord-015306-us58wwmp 4209 18 of of IN cord-015306-us58wwmp 4209 19 the the DT cord-015306-us58wwmp 4209 20 disease disease NN cord-015306-us58wwmp 4209 21 as as RB cord-015306-us58wwmp 4209 22 well well RB cord-015306-us58wwmp 4209 23 as as IN cord-015306-us58wwmp 4209 24 with with IN cord-015306-us58wwmp 4209 25 the the DT cord-015306-us58wwmp 4209 26 number number NN cord-015306-us58wwmp 4209 27 of of IN cord-015306-us58wwmp 4209 28 hospitalizations hospitalization NNS cord-015306-us58wwmp 4209 29 . . . cord-015306-us58wwmp 4210 1 PD PD NNP cord-015306-us58wwmp 4210 2 adolescents adolescent NNS cord-015306-us58wwmp 4210 3 in in IN cord-015306-us58wwmp 4210 4 the the DT cord-015306-us58wwmp 4210 5 mainstream mainstream NN cord-015306-us58wwmp 4210 6 education education NN cord-015306-us58wwmp 4210 7 had have VBD cord-015306-us58wwmp 4210 8 higher high JJR cord-015306-us58wwmp 4210 9 levels level NNS cord-015306-us58wwmp 4210 10 of of IN cord-015306-us58wwmp 4210 11 anxietystate anxietystate NN cord-015306-us58wwmp 4210 12 and and CC cord-015306-us58wwmp 4210 13 anxiety anxiety NN cord-015306-us58wwmp 4210 14 - - HYPH cord-015306-us58wwmp 4210 15 trait trait NN cord-015306-us58wwmp 4210 16 compared compare VBN cord-015306-us58wwmp 4210 17 with with IN cord-015306-us58wwmp 4210 18 home home NN cord-015306-us58wwmp 4210 19 schooled school VBN cord-015306-us58wwmp 4210 20 patients patient NNS cord-015306-us58wwmp 4210 21 . . . cord-015306-us58wwmp 4211 1 Conclusion conclusion NN cord-015306-us58wwmp 4211 2 : : : cord-015306-us58wwmp 4211 3 Even even RB cord-015306-us58wwmp 4211 4 though though IN cord-015306-us58wwmp 4211 5 children child NNS cord-015306-us58wwmp 4211 6 and and CC cord-015306-us58wwmp 4211 7 adolescents adolescent NNS cord-015306-us58wwmp 4211 8 with with IN cord-015306-us58wwmp 4211 9 CKD CKD NNP cord-015306-us58wwmp 4211 10 are be VBP cord-015306-us58wwmp 4211 11 at at IN cord-015306-us58wwmp 4211 12 risk risk NN cord-015306-us58wwmp 4211 13 of of IN cord-015306-us58wwmp 4211 14 developing develop VBG cord-015306-us58wwmp 4211 15 a a DT cord-015306-us58wwmp 4211 16 variety variety NN cord-015306-us58wwmp 4211 17 of of IN cord-015306-us58wwmp 4211 18 emotional emotional JJ cord-015306-us58wwmp 4211 19 disorders disorder NNS cord-015306-us58wwmp 4211 20 , , , cord-015306-us58wwmp 4211 21 the the DT cord-015306-us58wwmp 4211 22 level level NN cord-015306-us58wwmp 4211 23 of of IN cord-015306-us58wwmp 4211 24 anxiety anxiety NN cord-015306-us58wwmp 4211 25 among among IN cord-015306-us58wwmp 4211 26 the the DT cord-015306-us58wwmp 4211 27 researched research VBN cord-015306-us58wwmp 4211 28 group group NN cord-015306-us58wwmp 4211 29 , , , cord-015306-us58wwmp 4211 30 with with IN cord-015306-us58wwmp 4211 31 the the DT cord-015306-us58wwmp 4211 32 exception exception NN cord-015306-us58wwmp 4211 33 of of IN cord-015306-us58wwmp 4211 34 HD hd NN cord-015306-us58wwmp 4211 35 patients patient NNS cord-015306-us58wwmp 4211 36 , , , cord-015306-us58wwmp 4211 37 was be VBD cord-015306-us58wwmp 4211 38 not not RB cord-015306-us58wwmp 4211 39 significantly significantly RB cord-015306-us58wwmp 4211 40 different different JJ cord-015306-us58wwmp 4211 41 than than IN cord-015306-us58wwmp 4211 42 the the DT cord-015306-us58wwmp 4211 43 level level NN cord-015306-us58wwmp 4211 44 of of IN cord-015306-us58wwmp 4211 45 anxiety anxiety NN cord-015306-us58wwmp 4211 46 among among IN cord-015306-us58wwmp 4211 47 healthy healthy JJ cord-015306-us58wwmp 4211 48 subjects subject NNS cord-015306-us58wwmp 4211 49 . . . cord-015306-us58wwmp 4212 1 Adolescents adolescent NNS cord-015306-us58wwmp 4212 2 on on IN cord-015306-us58wwmp 4212 3 HD HD NNP cord-015306-us58wwmp 4212 4 who who WP cord-015306-us58wwmp 4212 5 present present VBP cord-015306-us58wwmp 4212 6 a a DT cord-015306-us58wwmp 4212 7 high high JJ cord-015306-us58wwmp 4212 8 level level NN cord-015306-us58wwmp 4212 9 of of IN cord-015306-us58wwmp 4212 10 anxiety anxiety NN cord-015306-us58wwmp 4212 11 should should MD cord-015306-us58wwmp 4212 12 undergo undergo VB cord-015306-us58wwmp 4212 13 long long JJ cord-015306-us58wwmp 4212 14 - - HYPH cord-015306-us58wwmp 4212 15 term term NN cord-015306-us58wwmp 4212 16 psychological psychological JJ cord-015306-us58wwmp 4212 17 treatment treatment NN cord-015306-us58wwmp 4212 18 . . . cord-015306-us58wwmp 4213 1 Ipek Ipek NNP cord-015306-us58wwmp 4213 2 Akil Akil NNP cord-015306-us58wwmp 4213 3 Objective Objective NNP cord-015306-us58wwmp 4213 4 : : : cord-015306-us58wwmp 4213 5 Compare compare VB cord-015306-us58wwmp 4213 6 medication medication NN cord-015306-us58wwmp 4213 7 adherence adherence NN cord-015306-us58wwmp 4213 8 and and CC cord-015306-us58wwmp 4213 9 kidney kidney NN cord-015306-us58wwmp 4213 10 graft graft NN cord-015306-us58wwmp 4213 11 loss loss NN cord-015306-us58wwmp 4213 12 rate rate NN cord-015306-us58wwmp 4213 13 before before RB cord-015306-us58wwmp 4213 14 and and CC cord-015306-us58wwmp 4213 15 after after IN cord-015306-us58wwmp 4213 16 transition transition NN cord-015306-us58wwmp 4213 17 in in IN cord-015306-us58wwmp 4213 18 a a DT cord-015306-us58wwmp 4213 19 single single JJ cord-015306-us58wwmp 4213 20 - - HYPH cord-015306-us58wwmp 4213 21 center center NN cord-015306-us58wwmp 4213 22 cohort cohort NN cord-015306-us58wwmp 4213 23 of of IN cord-015306-us58wwmp 4213 24 pediatric pediatric JJ cord-015306-us58wwmp 4213 25 patients patient NNS cord-015306-us58wwmp 4213 26 . . . cord-015306-us58wwmp 4214 1 Methods method NNS cord-015306-us58wwmp 4214 2 : : : cord-015306-us58wwmp 4214 3 Records record NNS cord-015306-us58wwmp 4214 4 of of IN cord-015306-us58wwmp 4214 5 the the DT cord-015306-us58wwmp 4214 6 patients patient NNS cord-015306-us58wwmp 4214 7 transplanted transplant VBN cord-015306-us58wwmp 4214 8 in in IN cord-015306-us58wwmp 4214 9 our -PRON- PRP$ cord-015306-us58wwmp 4214 10 center center NN cord-015306-us58wwmp 4214 11 between between IN cord-015306-us58wwmp 4214 12 1990 1990 CD cord-015306-us58wwmp 4214 13 and and CC cord-015306-us58wwmp 4214 14 2011 2011 CD cord-015306-us58wwmp 4214 15 were be VBD cord-015306-us58wwmp 4214 16 screened screen VBN cord-015306-us58wwmp 4214 17 and and CC cord-015306-us58wwmp 4214 18 patients patient NNS cord-015306-us58wwmp 4214 19 who who WP cord-015306-us58wwmp 4214 20 remained remain VBD cord-015306-us58wwmp 4214 21 in in IN cord-015306-us58wwmp 4214 22 the the DT cord-015306-us58wwmp 4214 23 program program NN cord-015306-us58wwmp 4214 24 by by IN cord-015306-us58wwmp 4214 25 their -PRON- PRP$ cord-015306-us58wwmp 4214 26 18th 18th JJ cord-015306-us58wwmp 4214 27 birthday birthday NN cord-015306-us58wwmp 4214 28 were be VBD cord-015306-us58wwmp 4214 29 included include VBN cord-015306-us58wwmp 4214 30 in in IN cord-015306-us58wwmp 4214 31 the the DT cord-015306-us58wwmp 4214 32 analysis analysis NN cord-015306-us58wwmp 4214 33 . . . cord-015306-us58wwmp 4215 1 Adherence adherence NN cord-015306-us58wwmp 4215 2 and and CC cord-015306-us58wwmp 4215 3 graft graft NN cord-015306-us58wwmp 4215 4 function function NN cord-015306-us58wwmp 4215 5 were be VBD cord-015306-us58wwmp 4215 6 assessed assess VBN cord-015306-us58wwmp 4215 7 for for IN cord-015306-us58wwmp 4215 8 the the DT cord-015306-us58wwmp 4215 9 period period NN cord-015306-us58wwmp 4215 10 of of IN cord-015306-us58wwmp 4215 11 2 2 CD cord-015306-us58wwmp 4215 12 years year NNS cord-015306-us58wwmp 4215 13 prior prior RB cord-015306-us58wwmp 4215 14 and and CC cord-015306-us58wwmp 4215 15 2 2 CD cord-015306-us58wwmp 4215 16 years year NNS cord-015306-us58wwmp 4215 17 after after IN cord-015306-us58wwmp 4215 18 transition transition NN cord-015306-us58wwmp 4215 19 . . . cord-015306-us58wwmp 4216 1 Undetectable undetectable JJ cord-015306-us58wwmp 4216 2 and/or and/or CC cord-015306-us58wwmp 4216 3 sub sub JJ cord-015306-us58wwmp 4216 4 - - JJ cord-015306-us58wwmp 4216 5 therapeutic therapeutic JJ cord-015306-us58wwmp 4216 6 levels level NNS cord-015306-us58wwmp 4216 7 of of IN cord-015306-us58wwmp 4216 8 calcineurin calcineurin NN cord-015306-us58wwmp 4216 9 inhibitors inhibitor NNS cord-015306-us58wwmp 4216 10 and and CC cord-015306-us58wwmp 4216 11 their -PRON- PRP$ cord-015306-us58wwmp 4216 12 level level NN cord-015306-us58wwmp 4216 13 variability variability NN cord-015306-us58wwmp 4216 14 were be VBD cord-015306-us58wwmp 4216 15 used use VBN cord-015306-us58wwmp 4216 16 as as IN cord-015306-us58wwmp 4216 17 measures measure NNS cord-015306-us58wwmp 4216 18 of of IN cord-015306-us58wwmp 4216 19 adherence adherence NN cord-015306-us58wwmp 4216 20 . . . cord-015306-us58wwmp 4217 1 Graft graft NN cord-015306-us58wwmp 4217 2 survival survival NN cord-015306-us58wwmp 4217 3 analysis analysis NN cord-015306-us58wwmp 4217 4 was be VBD cord-015306-us58wwmp 4217 5 performed perform VBN cord-015306-us58wwmp 4217 6 for for IN cord-015306-us58wwmp 4217 7 the the DT cord-015306-us58wwmp 4217 8 period period NN cord-015306-us58wwmp 4217 9 of of IN cord-015306-us58wwmp 4217 10 4 4 CD cord-015306-us58wwmp 4217 11 years year NNS cord-015306-us58wwmp 4217 12 before before RB cord-015306-us58wwmp 4217 13 and and CC cord-015306-us58wwmp 4217 14 4 4 CD cord-015306-us58wwmp 4217 15 years year NNS cord-015306-us58wwmp 4217 16 after after IN cord-015306-us58wwmp 4217 17 transition transition NN cord-015306-us58wwmp 4217 18 . . . cord-015306-us58wwmp 4218 1 Results result NNS cord-015306-us58wwmp 4218 2 : : : cord-015306-us58wwmp 4219 1 Out out IN cord-015306-us58wwmp 4219 2 of of IN cord-015306-us58wwmp 4219 3 197 197 CD cord-015306-us58wwmp 4219 4 screened screen VBN cord-015306-us58wwmp 4219 5 patients patient NNS cord-015306-us58wwmp 4219 6 , , , cord-015306-us58wwmp 4219 7 71 71 CD cord-015306-us58wwmp 4219 8 were be VBD cord-015306-us58wwmp 4219 9 eligible eligible JJ cord-015306-us58wwmp 4219 10 and and CC cord-015306-us58wwmp 4219 11 25 25 CD cord-015306-us58wwmp 4219 12 of of IN cord-015306-us58wwmp 4219 13 them -PRON- PRP cord-015306-us58wwmp 4219 14 were be VBD cord-015306-us58wwmp 4219 15 transitioned transition VBN cord-015306-us58wwmp 4219 16 ( ( -LRB- cord-015306-us58wwmp 4219 17 TG TG NNP cord-015306-us58wwmp 4219 18 -transitioned -transitioned JJ cord-015306-us58wwmp 4219 19 group group NN cord-015306-us58wwmp 4219 20 ) ) -RRB- cord-015306-us58wwmp 4219 21 . . . cord-015306-us58wwmp 4220 1 The the DT cord-015306-us58wwmp 4220 2 remaining remain VBG cord-015306-us58wwmp 4220 3 46 46 CD cord-015306-us58wwmp 4220 4 patients patient NNS cord-015306-us58wwmp 4220 5 were be VBD cord-015306-us58wwmp 4220 6 used use VBN cord-015306-us58wwmp 4220 7 as as IN cord-015306-us58wwmp 4220 8 a a DT cord-015306-us58wwmp 4220 9 comparison comparison NN cord-015306-us58wwmp 4220 10 group group NN cord-015306-us58wwmp 4220 11 ( ( -LRB- cord-015306-us58wwmp 4220 12 CG CG NNP cord-015306-us58wwmp 4220 13 ) ) -RRB- cord-015306-us58wwmp 4220 14 , , , cord-015306-us58wwmp 4220 15 27 27 CD cord-015306-us58wwmp 4220 16 of of IN cord-015306-us58wwmp 4220 17 them -PRON- PRP cord-015306-us58wwmp 4220 18 did do VBD cord-015306-us58wwmp 4220 19 not not RB cord-015306-us58wwmp 4220 20 reach reach VB cord-015306-us58wwmp 4220 21 the the DT cord-015306-us58wwmp 4220 22 age age NN cord-015306-us58wwmp 4220 23 of of IN cord-015306-us58wwmp 4220 24 transition transition NN cord-015306-us58wwmp 4220 25 by by IN cord-015306-us58wwmp 4220 26 the the DT cord-015306-us58wwmp 4220 27 time time NN cord-015306-us58wwmp 4220 28 of of IN cord-015306-us58wwmp 4220 29 the the DT cord-015306-us58wwmp 4220 30 analysis analysis NN cord-015306-us58wwmp 4220 31 . . . cord-015306-us58wwmp 4221 1 The the DT cord-015306-us58wwmp 4221 2 median median JJ cord-015306-us58wwmp 4221 3 age age NN cord-015306-us58wwmp 4221 4 at at IN cord-015306-us58wwmp 4221 5 transplantation transplantation NN cord-015306-us58wwmp 4221 6 was be VBD cord-015306-us58wwmp 4221 7 17.7 17.7 CD cord-015306-us58wwmp 4221 8 [ [ -LRB- cord-015306-us58wwmp 4221 9 15.1 15.1 CD cord-015306-us58wwmp 4221 10 - - HYPH cord-015306-us58wwmp 4221 11 19.1 19.1 CD cord-015306-us58wwmp 4221 12 ] ] -RRB- cord-015306-us58wwmp 4221 13 years year NNS cord-015306-us58wwmp 4221 14 in in IN cord-015306-us58wwmp 4221 15 the the DT cord-015306-us58wwmp 4221 16 TG TG NNP cord-015306-us58wwmp 4221 17 and and CC cord-015306-us58wwmp 4221 18 15.8 15.8 CD cord-015306-us58wwmp 4221 19 [ [ -LRB- cord-015306-us58wwmp 4221 20 13.5 13.5 CD cord-015306-us58wwmp 4221 21 - - HYPH cord-015306-us58wwmp 4221 22 17.6 17.6 CD cord-015306-us58wwmp 4221 23 ] ] -RRB- cord-015306-us58wwmp 4221 24 years year NNS cord-015306-us58wwmp 4221 25 in in IN cord-015306-us58wwmp 4221 26 the the DT cord-015306-us58wwmp 4221 27 CG CG NNP cord-015306-us58wwmp 4221 28 , , , cord-015306-us58wwmp 4221 29 median median JJ cord-015306-us58wwmp 4221 30 age age NN cord-015306-us58wwmp 4221 31 at at IN cord-015306-us58wwmp 4221 32 transition transition NN cord-015306-us58wwmp 4221 33 was be VBD cord-015306-us58wwmp 4221 34 22 22 CD cord-015306-us58wwmp 4221 35 . . . cord-015306-us58wwmp 4222 1 5 5 LS cord-015306-us58wwmp 4222 2 [ [ -LRB- cord-015306-us58wwmp 4222 3 21.7 21.7 CD cord-015306-us58wwmp 4222 4 - - SYM cord-015306-us58wwmp 4222 5 23 23 CD cord-015306-us58wwmp 4222 6 .3 .3 NFP cord-015306-us58wwmp 4222 7 ] ] -RRB- cord-015306-us58wwmp 4222 8 years year NNS cord-015306-us58wwmp 4222 9 . . . cord-015306-us58wwmp 4223 1 Overall overall RB cord-015306-us58wwmp 4223 2 , , , cord-015306-us58wwmp 4223 3 there there EX cord-015306-us58wwmp 4223 4 was be VBD cord-015306-us58wwmp 4223 5 no no DT cord-015306-us58wwmp 4223 6 significant significant JJ cord-015306-us58wwmp 4223 7 difference difference NN cord-015306-us58wwmp 4223 8 in in IN cord-015306-us58wwmp 4223 9 adherence adherence NN cord-015306-us58wwmp 4223 10 within within IN cord-015306-us58wwmp 4223 11 TG TG NNP cord-015306-us58wwmp 4223 12 before before RB cord-015306-us58wwmp 4223 13 and and CC cord-015306-us58wwmp 4223 14 after after IN cord-015306-us58wwmp 4223 15 transition transition NN cord-015306-us58wwmp 4223 16 ( ( -LRB- cord-015306-us58wwmp 4223 17 p=0.5 p=0.5 NNP cord-015306-us58wwmp 4223 18 for for IN cord-015306-us58wwmp 4223 19 low low JJ cord-015306-us58wwmp 4223 20 drug drug NN cord-015306-us58wwmp 4223 21 levels level NNS cord-015306-us58wwmp 4223 22 and and CC cord-015306-us58wwmp 4223 23 p=0.6 p=0.6 NN cord-015306-us58wwmp 4223 24 for for IN cord-015306-us58wwmp 4223 25 drug drug NN cord-015306-us58wwmp 4223 26 levels level NNS cord-015306-us58wwmp 4223 27 variability variability NN cord-015306-us58wwmp 4223 28 ) ) -RRB- cord-015306-us58wwmp 4223 29 ; ; : cord-015306-us58wwmp 4223 30 however however RB cord-015306-us58wwmp 4223 31 , , , cord-015306-us58wwmp 4223 32 patients patient NNS cord-015306-us58wwmp 4223 33 with with IN cord-015306-us58wwmp 4223 34 lower low JJR cord-015306-us58wwmp 4223 35 pre pre JJ cord-015306-us58wwmp 4223 36 - - JJ cord-015306-us58wwmp 4223 37 transition transition JJ cord-015306-us58wwmp 4223 38 adherence adherence NN cord-015306-us58wwmp 4223 39 ( ( -LRB- cord-015306-us58wwmp 4223 40 tertile tertile NNP cord-015306-us58wwmp 4223 41 I I NNP cord-015306-us58wwmp 4223 42 ) ) -RRB- cord-015306-us58wwmp 4223 43 showed show VBD cord-015306-us58wwmp 4223 44 improvement improvement NN cord-015306-us58wwmp 4223 45 of of IN cord-015306-us58wwmp 4223 46 their -PRON- PRP$ cord-015306-us58wwmp 4223 47 adherence adherence NN cord-015306-us58wwmp 4223 48 following follow VBG cord-015306-us58wwmp 4223 49 transition transition NN cord-015306-us58wwmp 4223 50 when when WRB cord-015306-us58wwmp 4223 51 compared compare VBN cord-015306-us58wwmp 4223 52 with with IN cord-015306-us58wwmp 4223 53 those those DT cord-015306-us58wwmp 4223 54 with with IN cord-015306-us58wwmp 4223 55 high high JJ cord-015306-us58wwmp 4223 56 pre pre JJ cord-015306-us58wwmp 4223 57 - - JJ cord-015306-us58wwmp 4223 58 transition transition JJ cord-015306-us58wwmp 4223 59 adherence adherence NN cord-015306-us58wwmp 4223 60 ( ( -LRB- cord-015306-us58wwmp 4223 61 tertile tertile NNP cord-015306-us58wwmp 4223 62 III III NNP cord-015306-us58wwmp 4223 63 ) ) -RRB- cord-015306-us58wwmp 4224 1 , , , cord-015306-us58wwmp 4224 2 p=0.02 p=0.02 NNP cord-015306-us58wwmp 4224 3 . . . cord-015306-us58wwmp 4225 1 There there EX cord-015306-us58wwmp 4225 2 were be VBD cord-015306-us58wwmp 4225 3 4 4 CD cord-015306-us58wwmp 4225 4 graft graft NN cord-015306-us58wwmp 4225 5 losses loss NNS cord-015306-us58wwmp 4225 6 per per IN cord-015306-us58wwmp 4225 7 67.9 67.9 CD cord-015306-us58wwmp 4225 8 patient patient NN cord-015306-us58wwmp 4225 9 - - HYPH cord-015306-us58wwmp 4225 10 years year NNS cord-015306-us58wwmp 4225 11 in in IN cord-015306-us58wwmp 4225 12 TG TG NNP cord-015306-us58wwmp 4225 13 vs vs IN cord-015306-us58wwmp 4225 14 19 19 CD cord-015306-us58wwmp 4225 15 losses loss NNS cord-015306-us58wwmp 4225 16 per per IN cord-015306-us58wwmp 4225 17 102.4 102.4 CD cord-015306-us58wwmp 4225 18 person person NN cord-015306-us58wwmp 4225 19 - - HYPH cord-015306-us58wwmp 4225 20 years year NNS cord-015306-us58wwmp 4225 21 in in IN cord-015306-us58wwmp 4225 22 CG CG NNP cord-015306-us58wwmp 4225 23 ( ( -LRB- cord-015306-us58wwmp 4225 24 p=0.02 p=0.02 NNP cord-015306-us58wwmp 4225 25 ) ) -RRB- cord-015306-us58wwmp 4225 26 . . . cord-015306-us58wwmp 4226 1 The the DT cord-015306-us58wwmp 4226 2 peak peak NN cord-015306-us58wwmp 4226 3 graft graft NN cord-015306-us58wwmp 4226 4 loss loss NN cord-015306-us58wwmp 4226 5 in in IN cord-015306-us58wwmp 4226 6 all all DT cord-015306-us58wwmp 4226 7 pediatric pediatric JJ cord-015306-us58wwmp 4226 8 transplant transplant NN cord-015306-us58wwmp 4226 9 recipients recipient NNS cord-015306-us58wwmp 4226 10 in in IN cord-015306-us58wwmp 4226 11 our -PRON- PRP$ cord-015306-us58wwmp 4226 12 center center NN cord-015306-us58wwmp 4226 13 ( ( -LRB- cord-015306-us58wwmp 4226 14 n=105 n=105 CD cord-015306-us58wwmp 4226 15 losses loss NNS cord-015306-us58wwmp 4226 16 ) ) -RRB- cord-015306-us58wwmp 4226 17 occurred occur VBD cord-015306-us58wwmp 4226 18 3 3 CD cord-015306-us58wwmp 4226 19 years year NNS cord-015306-us58wwmp 4226 20 ( ( -LRB- cord-015306-us58wwmp 4226 21 SD SD NNP cord-015306-us58wwmp 4226 22 5.7 5.7 CD cord-015306-us58wwmp 4226 23 years year NNS cord-015306-us58wwmp 4226 24 ) ) -RRB- cord-015306-us58wwmp 4226 25 prior prior RB cord-015306-us58wwmp 4226 26 to to IN cord-015306-us58wwmp 4226 27 the the DT cord-015306-us58wwmp 4226 28 transition transition NN cord-015306-us58wwmp 4226 29 . . . cord-015306-us58wwmp 4227 1 Conclusion conclusion NN cord-015306-us58wwmp 4227 2 : : : cord-015306-us58wwmp 4227 3 At at IN cord-015306-us58wwmp 4227 4 our -PRON- PRP$ cord-015306-us58wwmp 4227 5 institution institution NN cord-015306-us58wwmp 4227 6 , , , cord-015306-us58wwmp 4227 7 transition transition NN cord-015306-us58wwmp 4227 8 was be VBD cord-015306-us58wwmp 4227 9 not not RB cord-015306-us58wwmp 4227 10 associated associate VBN cord-015306-us58wwmp 4227 11 with with IN cord-015306-us58wwmp 4227 12 worsening worsen VBG cord-015306-us58wwmp 4227 13 adherence adherence NN cord-015306-us58wwmp 4227 14 or or CC cord-015306-us58wwmp 4227 15 graft graft NN cord-015306-us58wwmp 4227 16 loss loss NN cord-015306-us58wwmp 4227 17 . . . cord-015306-us58wwmp 4228 1 This this DT cord-015306-us58wwmp 4228 2 may may MD cord-015306-us58wwmp 4228 3 be be VB cord-015306-us58wwmp 4228 4 in in IN cord-015306-us58wwmp 4228 5 part part NN cord-015306-us58wwmp 4228 6 do do VB cord-015306-us58wwmp 4228 7 to to IN cord-015306-us58wwmp 4228 8 the the DT cord-015306-us58wwmp 4228 9 fact fact NN cord-015306-us58wwmp 4228 10 that that IN cord-015306-us58wwmp 4228 11 the the DT cord-015306-us58wwmp 4228 12 transition transition NN cord-015306-us58wwmp 4228 13 occurred occur VBD cord-015306-us58wwmp 4228 14 at at IN cord-015306-us58wwmp 4228 15 a a DT cord-015306-us58wwmp 4228 16 later later JJ cord-015306-us58wwmp 4228 17 age age NN cord-015306-us58wwmp 4228 18 than than IN cord-015306-us58wwmp 4228 19 in in IN cord-015306-us58wwmp 4228 20 other other JJ cord-015306-us58wwmp 4228 21 institutions institution NNS cord-015306-us58wwmp 4228 22 . . . cord-015306-us58wwmp 4229 1 A a DT cord-015306-us58wwmp 4229 2 report report NN cord-015306-us58wwmp 4229 3 on on IN cord-015306-us58wwmp 4229 4 7-years 7-years CD cord-015306-us58wwmp 4229 5 experience experience NN cord-015306-us58wwmp 4229 6 in in IN cord-015306-us58wwmp 4229 7 the the DT cord-015306-us58wwmp 4229 8 use use NN cord-015306-us58wwmp 4229 9 of of IN cord-015306-us58wwmp 4229 10 mTOR mtor NN cord-015306-us58wwmp 4229 11 - - HYPH cord-015306-us58wwmp 4229 12 inhibitor inhibitor NN cord-015306-us58wwmp 4229 13 ( ( -LRB- cord-015306-us58wwmp 4229 14 Sirolimus Sirolimus NNP cord-015306-us58wwmp 4229 15 ) ) -RRB- cord-015306-us58wwmp 4229 16 in in IN cord-015306-us58wwmp 4229 17 Paediatric paediatric JJ cord-015306-us58wwmp 4229 18 renal renal JJ cord-015306-us58wwmp 4229 19 transplantation transplantation NN cord-015306-us58wwmp 4229 20 patients patient NNS cord-015306-us58wwmp 4229 21 with with IN cord-015306-us58wwmp 4229 22 Calcineurin Calcineurin NNP cord-015306-us58wwmp 4229 23 inhibitor inhibitor NN cord-015306-us58wwmp 4229 24 ( ( -LRB- cord-015306-us58wwmp 4229 25 CNI CNI NNP cord-015306-us58wwmp 4229 26 ) ) -RRB- cord-015306-us58wwmp 4229 27 toxicity toxicity NN cord-015306-us58wwmp 4230 1 The the DT cord-015306-us58wwmp 4230 2 management management NN cord-015306-us58wwmp 4230 3 of of IN cord-015306-us58wwmp 4230 4 children child NNS cord-015306-us58wwmp 4230 5 with with IN cord-015306-us58wwmp 4230 6 end end NN cord-015306-us58wwmp 4230 7 - - HYPH cord-015306-us58wwmp 4230 8 stage stage NN cord-015306-us58wwmp 4230 9 renal renal JJ cord-015306-us58wwmp 4230 10 disease disease NN cord-015306-us58wwmp 4230 11 ( ( -LRB- cord-015306-us58wwmp 4230 12 ESRD ESRD NNP cord-015306-us58wwmp 4230 13 ) ) -RRB- cord-015306-us58wwmp 4230 14 deu deu JJ cord-015306-us58wwmp 4230 15 to to IN cord-015306-us58wwmp 4230 16 congenital congenital JJ cord-015306-us58wwmp 4230 17 urological urological JJ cord-015306-us58wwmp 4230 18 abnormalities abnormality NNS cord-015306-us58wwmp 4230 19 is be VBZ cord-015306-us58wwmp 4230 20 more more RBR cord-015306-us58wwmp 4230 21 problematic problematic JJ cord-015306-us58wwmp 4230 22 and and CC cord-015306-us58wwmp 4230 23 difficult difficult JJ cord-015306-us58wwmp 4230 24 than than IN cord-015306-us58wwmp 4230 25 in in IN cord-015306-us58wwmp 4230 26 patients patient NNS cord-015306-us58wwmp 4230 27 with with IN cord-015306-us58wwmp 4230 28 ESRD ESRD NNP cord-015306-us58wwmp 4230 29 due due IN cord-015306-us58wwmp 4230 30 to to IN cord-015306-us58wwmp 4230 31 other other JJ cord-015306-us58wwmp 4230 32 causes cause NNS cord-015306-us58wwmp 4230 33 . . . cord-015306-us58wwmp 4231 1 Kidney kidney NN cord-015306-us58wwmp 4231 2 transplantation transplantation NN cord-015306-us58wwmp 4231 3 in in IN cord-015306-us58wwmp 4231 4 neurogenic neurogenic JJ cord-015306-us58wwmp 4231 5 bladder bladder NN cord-015306-us58wwmp 4231 6 patients patient NNS cord-015306-us58wwmp 4231 7 with with IN cord-015306-us58wwmp 4231 8 small small JJ cord-015306-us58wwmp 4231 9 capacity capacity NN cord-015306-us58wwmp 4231 10 and and CC cord-015306-us58wwmp 4231 11 defunctionionalized defunctionionalized JJ cord-015306-us58wwmp 4231 12 urinary urinary JJ cord-015306-us58wwmp 4231 13 bladders bladder NNS cord-015306-us58wwmp 4231 14 is be VBZ cord-015306-us58wwmp 4231 15 a a DT cord-015306-us58wwmp 4231 16 challenging challenging JJ cord-015306-us58wwmp 4231 17 issue issue NN cord-015306-us58wwmp 4231 18 in in IN cord-015306-us58wwmp 4231 19 the the DT cord-015306-us58wwmp 4231 20 field field NN cord-015306-us58wwmp 4231 21 of of IN cord-015306-us58wwmp 4231 22 pediatric pediatric JJ cord-015306-us58wwmp 4231 23 transplantation transplantation NN cord-015306-us58wwmp 4231 24 . . . cord-015306-us58wwmp 4232 1 In in IN cord-015306-us58wwmp 4232 2 these these DT cord-015306-us58wwmp 4232 3 patients patient NNS cord-015306-us58wwmp 4232 4 with with IN cord-015306-us58wwmp 4232 5 severe severe JJ cord-015306-us58wwmp 4232 6 bladder bladder NN cord-015306-us58wwmp 4232 7 dysfunction dysfunction NN cord-015306-us58wwmp 4232 8 , , , cord-015306-us58wwmp 4232 9 augmentation augmentation NN cord-015306-us58wwmp 4232 10 cystoplasty cystoplasty NN cord-015306-us58wwmp 4232 11 can can MD cord-015306-us58wwmp 4232 12 protect protect VB cord-015306-us58wwmp 4232 13 the the DT cord-015306-us58wwmp 4232 14 transplanted transplant VBN cord-015306-us58wwmp 4232 15 kidney kidney NN cord-015306-us58wwmp 4232 16 by by IN cord-015306-us58wwmp 4232 17 reducing reduce VBG cord-015306-us58wwmp 4232 18 intravesical intravesical JJ cord-015306-us58wwmp 4232 19 pressure pressure NN cord-015306-us58wwmp 4232 20 and and CC cord-015306-us58wwmp 4232 21 creating create VBG cord-015306-us58wwmp 4232 22 an an DT cord-015306-us58wwmp 4232 23 appropriate appropriate JJ cord-015306-us58wwmp 4232 24 capacity capacity NN cord-015306-us58wwmp 4232 25 . . . cord-015306-us58wwmp 4233 1 8-year 8-year JJ cord-015306-us58wwmp 4233 2 - - HYPH cord-015306-us58wwmp 4233 3 old old JJ cord-015306-us58wwmp 4233 4 boy boy NN cord-015306-us58wwmp 4233 5 who who WP cord-015306-us58wwmp 4233 6 presented present VBD cord-015306-us58wwmp 4233 7 urinary urinary JJ cord-015306-us58wwmp 4233 8 tract tract NN cord-015306-us58wwmp 4233 9 infection infection NN cord-015306-us58wwmp 4233 10 with with IN cord-015306-us58wwmp 4233 11 fever fever NN cord-015306-us58wwmp 4233 12 at at IN cord-015306-us58wwmp 4233 13 2 2 CD cord-015306-us58wwmp 4233 14 year year NN cord-015306-us58wwmp 4233 15 - - HYPH cord-015306-us58wwmp 4233 16 old old JJ cord-015306-us58wwmp 4233 17 and and CC cord-015306-us58wwmp 4233 18 while while IN cord-015306-us58wwmp 4233 19 his -PRON- PRP$ cord-015306-us58wwmp 4233 20 investigation investigation NN cord-015306-us58wwmp 4233 21 , , , cord-015306-us58wwmp 4233 22 stage stage NN cord-015306-us58wwmp 4233 23 3 3 CD cord-015306-us58wwmp 4233 24 chronic chronic JJ cord-015306-us58wwmp 4233 25 kidney kidney NN cord-015306-us58wwmp 4233 26 disease disease NN cord-015306-us58wwmp 4233 27 secondary secondary JJ cord-015306-us58wwmp 4233 28 to to IN cord-015306-us58wwmp 4233 29 bilateral bilateral JJ cord-015306-us58wwmp 4233 30 grade grade NN cord-015306-us58wwmp 4233 31 5 5 CD cord-015306-us58wwmp 4233 32 reflux reflux NN cord-015306-us58wwmp 4233 33 disease disease NN cord-015306-us58wwmp 4233 34 was be VBD cord-015306-us58wwmp 4233 35 found find VBN cord-015306-us58wwmp 4233 36 ( ( -LRB- cord-015306-us58wwmp 4233 37 blood blood NN cord-015306-us58wwmp 4233 38 urea urea NN cord-015306-us58wwmp 4233 39 : : : cord-015306-us58wwmp 4233 40 81 81 CD cord-015306-us58wwmp 4233 41 mg mg NNP cord-015306-us58wwmp 4233 42 / / SYM cord-015306-us58wwmp 4233 43 dl dl NNP cord-015306-us58wwmp 4233 44 , , , cord-015306-us58wwmp 4233 45 creatinin creatinin NNP cord-015306-us58wwmp 4233 46 : : : cord-015306-us58wwmp 4233 47 1.5 1.5 CD cord-015306-us58wwmp 4233 48 mg mg NNP cord-015306-us58wwmp 4233 49 / / SYM cord-015306-us58wwmp 4233 50 dl dl NNP cord-015306-us58wwmp 4233 51 , , , cord-015306-us58wwmp 4233 52 creatinin creatinin NNP cord-015306-us58wwmp 4233 53 clerance clerance NNP cord-015306-us58wwmp 4233 54 : : : cord-015306-us58wwmp 4233 55 32 32 CD cord-015306-us58wwmp 4233 56 ml ml NN cord-015306-us58wwmp 4233 57 / / SYM cord-015306-us58wwmp 4233 58 min/1.73 min/1.73 JJ cord-015306-us58wwmp 4233 59 m m CD cord-015306-us58wwmp 4233 60 2 2 CD cord-015306-us58wwmp 4233 61 ) ) -RRB- cord-015306-us58wwmp 4233 62 . . . cord-015306-us58wwmp 4234 1 His -PRON- PRP$ cord-015306-us58wwmp 4234 2 mixiocystoureterographic mixiocystoureterographic JJ cord-015306-us58wwmp 4234 3 and and CC cord-015306-us58wwmp 4234 4 urodynamic urodynamic JJ cord-015306-us58wwmp 4234 5 study study NN cord-015306-us58wwmp 4234 6 were be VBD cord-015306-us58wwmp 4234 7 showed show VBN cord-015306-us58wwmp 4234 8 bladder bladder NN cord-015306-us58wwmp 4234 9 wall wall NN cord-015306-us58wwmp 4234 10 irregularity irregularity NN cord-015306-us58wwmp 4234 11 and and CC cord-015306-us58wwmp 4234 12 trabeculation trabeculation NN cord-015306-us58wwmp 4234 13 ; ; , cord-015306-us58wwmp 4234 14 decreased decrease VBD cord-015306-us58wwmp 4234 15 bladder bladder NN cord-015306-us58wwmp 4234 16 capacity capacity NN cord-015306-us58wwmp 4234 17 and and CC cord-015306-us58wwmp 4234 18 compliance compliance NN cord-015306-us58wwmp 4234 19 , , , cord-015306-us58wwmp 4234 20 respectively respectively RB cord-015306-us58wwmp 4234 21 . . . cord-015306-us58wwmp 4235 1 At at IN cord-015306-us58wwmp 4235 2 8-month 8-month CD cord-015306-us58wwmp 4235 3 of of IN cord-015306-us58wwmp 4235 4 followup followup NN cord-015306-us58wwmp 4235 5 he -PRON- PRP cord-015306-us58wwmp 4235 6 was be VBD cord-015306-us58wwmp 4235 7 putted putt VBN cord-015306-us58wwmp 4235 8 into into IN cord-015306-us58wwmp 4235 9 dialysis dialysis NN cord-015306-us58wwmp 4235 10 programme programme NN cord-015306-us58wwmp 4235 11 about about RB cord-015306-us58wwmp 4235 12 6 6 CD cord-015306-us58wwmp 4235 13 years year NNS cord-015306-us58wwmp 4235 14 . . . cord-015306-us58wwmp 4236 1 Thereafter thereafter RB cord-015306-us58wwmp 4236 2 , , , cord-015306-us58wwmp 4236 3 normal normal JJ cord-015306-us58wwmp 4236 4 bladder bladder NN cord-015306-us58wwmp 4236 5 capacity capacity NN cord-015306-us58wwmp 4236 6 was be VBD cord-015306-us58wwmp 4236 7 achieved achieve VBN cord-015306-us58wwmp 4236 8 after after IN cord-015306-us58wwmp 4236 9 bladder bladder NN cord-015306-us58wwmp 4236 10 augmentation augmentation NN cord-015306-us58wwmp 4236 11 implementation implementation NN cord-015306-us58wwmp 4236 12 . . . cord-015306-us58wwmp 4237 1 He -PRON- PRP cord-015306-us58wwmp 4237 2 was be VBD cord-015306-us58wwmp 4237 3 achieved achieve VBN cord-015306-us58wwmp 4237 4 renal renal JJ cord-015306-us58wwmp 4237 5 transplantation transplantation NN cord-015306-us58wwmp 4237 6 from from IN cord-015306-us58wwmp 4237 7 his -PRON- PRP$ cord-015306-us58wwmp 4237 8 mother mother NN cord-015306-us58wwmp 4237 9 , , , cord-015306-us58wwmp 4237 10 after after IN cord-015306-us58wwmp 4237 11 6-month 6-month CD cord-015306-us58wwmp 4237 12 of of IN cord-015306-us58wwmp 4237 13 augmentation augmentation NN cord-015306-us58wwmp 4237 14 operation operation NN cord-015306-us58wwmp 4237 15 . . . cord-015306-us58wwmp 4238 1 Now now RB cord-015306-us58wwmp 4238 2 , , , cord-015306-us58wwmp 4238 3 he -PRON- PRP cord-015306-us58wwmp 4238 4 still still RB cord-015306-us58wwmp 4238 5 got get VBD cord-015306-us58wwmp 4238 6 uneventfull uneventfull JJ cord-015306-us58wwmp 4238 7 follow follow NN cord-015306-us58wwmp 4238 8 - - HYPH cord-015306-us58wwmp 4238 9 up up NN cord-015306-us58wwmp 4238 10 period period NN cord-015306-us58wwmp 4238 11 about about RB cord-015306-us58wwmp 4238 12 24 24 CD cord-015306-us58wwmp 4238 13 months month NNS cord-015306-us58wwmp 4238 14 . . . cord-015306-us58wwmp 4239 1 Consequently consequently RB cord-015306-us58wwmp 4239 2 , , , cord-015306-us58wwmp 4239 3 bladder bladder NN cord-015306-us58wwmp 4239 4 augmentation augmentation NN cord-015306-us58wwmp 4239 5 application application NN cord-015306-us58wwmp 4239 6 with with IN cord-015306-us58wwmp 4239 7 timely timely JJ cord-015306-us58wwmp 4239 8 and and CC cord-015306-us58wwmp 4239 9 rationally rationally RB cord-015306-us58wwmp 4239 10 could could MD cord-015306-us58wwmp 4239 11 be be VB cord-015306-us58wwmp 4239 12 a a DT cord-015306-us58wwmp 4239 13 chance chance NN cord-015306-us58wwmp 4239 14 to to IN cord-015306-us58wwmp 4239 15 kidney kidney NN cord-015306-us58wwmp 4239 16 transplantation transplantation NN cord-015306-us58wwmp 4239 17 in in IN cord-015306-us58wwmp 4239 18 children child NNS cord-015306-us58wwmp 4239 19 with with IN cord-015306-us58wwmp 4239 20 bladder bladder NN cord-015306-us58wwmp 4239 21 dysfunction dysfunction NN cord-015306-us58wwmp 4239 22 . . . cord-015306-us58wwmp 4240 1 The the DT cord-015306-us58wwmp 4240 2 Effect Effect NNP cord-015306-us58wwmp 4240 3 Of of IN cord-015306-us58wwmp 4240 4 Anti Anti NNP cord-015306-us58wwmp 4240 5 - - NNP cord-015306-us58wwmp 4240 6 Hla Hla NNP cord-015306-us58wwmp 4240 7 Antibodies Antibodies NNPS cord-015306-us58wwmp 4240 8 On on IN cord-015306-us58wwmp 4240 9 Renal Renal NNP cord-015306-us58wwmp 4240 10 Graft Graft NNP cord-015306-us58wwmp 4240 11 Functions Functions NNPS cord-015306-us58wwmp 4240 12 Esra Esra NNP cord-015306-us58wwmp 4240 13 Baskin Baskin NNP cord-015306-us58wwmp 4240 14 1 1 CD cord-015306-us58wwmp 4240 15 , , , cord-015306-us58wwmp 4240 16 Asli Asli NNP cord-015306-us58wwmp 4240 17 Kantar Kantar NNP cord-015306-us58wwmp 4240 18 1 1 CD cord-015306-us58wwmp 4240 19 Umut Umut NNP cord-015306-us58wwmp 4240 20 Bayrakci Bayrakci NNP cord-015306-us58wwmp 4240 21 1 1 CD cord-015306-us58wwmp 4240 22 , , , cord-015306-us58wwmp 4240 23 Kaan Kaan NNP cord-015306-us58wwmp 4240 24 Gulleroglu Gulleroglu NNP cord-015306-us58wwmp 4240 25 1 1 CD cord-015306-us58wwmp 4240 26 , , , cord-015306-us58wwmp 4240 27 Mahir Mahir NNP cord-015306-us58wwmp 4240 28 Kirnap Kirnap NNP cord-015306-us58wwmp 4240 29 1 1 CD cord-015306-us58wwmp 4240 30 , , , cord-015306-us58wwmp 4240 31 2 2 CD cord-015306-us58wwmp 4240 32 , , , cord-015306-us58wwmp 4240 33 Feza Feza NNP cord-015306-us58wwmp 4240 34 Karakayali Karakayali NNP cord-015306-us58wwmp 4240 35 1 1 CD cord-015306-us58wwmp 4240 36 , , , cord-015306-us58wwmp 4240 37 2 2 CD cord-015306-us58wwmp 4240 38 , , , cord-015306-us58wwmp 4240 39 Aysegul Aysegul NNP cord-015306-us58wwmp 4240 40 Haberal Haberal NNP cord-015306-us58wwmp 4240 41 1 1 CD cord-015306-us58wwmp 4240 42 , , , cord-015306-us58wwmp 4240 43 3 3 CD cord-015306-us58wwmp 4240 44 , , , cord-015306-us58wwmp 4240 45 Gokhan Gokhan NNP cord-015306-us58wwmp 4240 46 Moray Moray NNP cord-015306-us58wwmp 4240 47 1 1 CD cord-015306-us58wwmp 4240 48 , , , cord-015306-us58wwmp 4240 49 2 2 CD cord-015306-us58wwmp 4240 50 , , , cord-015306-us58wwmp 4240 51 Mehmet Mehmet NNP cord-015306-us58wwmp 4240 52 Haberal Haberal NNP cord-015306-us58wwmp 4240 53 1 1 CD cord-015306-us58wwmp 4240 54 , , , cord-015306-us58wwmp 4240 55 2 2 CD cord-015306-us58wwmp 4240 56 1 1 CD cord-015306-us58wwmp 4240 57 Pediatric Pediatric NNP cord-015306-us58wwmp 4240 58 Nephrology Nephrology NNP cord-015306-us58wwmp 4240 59 , , , cord-015306-us58wwmp 4240 60 Baskent Baskent NNP cord-015306-us58wwmp 4240 61 University University NNP cord-015306-us58wwmp 4240 62 , , , cord-015306-us58wwmp 4240 63 Ankara Ankara NNP cord-015306-us58wwmp 4240 64 , , , cord-015306-us58wwmp 4240 65 Turkey Turkey NNP cord-015306-us58wwmp 4240 66 2 2 CD cord-015306-us58wwmp 4240 67 General General NNP cord-015306-us58wwmp 4240 68 Surgery Surgery NNP cord-015306-us58wwmp 4240 69 , , , cord-015306-us58wwmp 4240 70 Baskent Baskent NNP cord-015306-us58wwmp 4240 71 University University NNP cord-015306-us58wwmp 4240 72 , , , cord-015306-us58wwmp 4240 73 Ankara Ankara NNP cord-015306-us58wwmp 4240 74 , , , cord-015306-us58wwmp 4240 75 Turkey Turkey NNP cord-015306-us58wwmp 4240 76 3 3 CD cord-015306-us58wwmp 4240 77 Immunology Immunology NNP cord-015306-us58wwmp 4240 78 , , , cord-015306-us58wwmp 4240 79 Baskent Baskent NNP cord-015306-us58wwmp 4240 80 University University NNP cord-015306-us58wwmp 4240 81 , , , cord-015306-us58wwmp 4240 82 Ankara Ankara NNP cord-015306-us58wwmp 4240 83 , , , cord-015306-us58wwmp 4240 84 TurkeyObjective TurkeyObjective NNP cord-015306-us58wwmp 4240 85 : : : cord-015306-us58wwmp 4241 1 The the DT cord-015306-us58wwmp 4241 2 identification identification NN cord-015306-us58wwmp 4241 3 of of IN cord-015306-us58wwmp 4241 4 suitable suitable JJ cord-015306-us58wwmp 4241 5 donor donor NN cord-015306-us58wwmp 4241 6 kidneys kidney NNS cord-015306-us58wwmp 4241 7 for for IN cord-015306-us58wwmp 4241 8 transplant transplant NN cord-015306-us58wwmp 4241 9 candidates candidate NNS cord-015306-us58wwmp 4241 10 with with IN cord-015306-us58wwmp 4241 11 high high JJ cord-015306-us58wwmp 4241 12 levels level NNS cord-015306-us58wwmp 4241 13 of of IN cord-015306-us58wwmp 4241 14 circulating circulate VBG cord-015306-us58wwmp 4241 15 antibodies antibody NNS cord-015306-us58wwmp 4241 16 against against IN cord-015306-us58wwmp 4241 17 human human JJ cord-015306-us58wwmp 4241 18 leukocyte leukocyte NN cord-015306-us58wwmp 4241 19 antigen antigen NN cord-015306-us58wwmp 4241 20 ( ( -LRB- cord-015306-us58wwmp 4241 21 HLA HLA NNP cord-015306-us58wwmp 4241 22 ) ) -RRB- cord-015306-us58wwmp 4241 23 is be VBZ cord-015306-us58wwmp 4241 24 a a DT cord-015306-us58wwmp 4241 25 major major JJ cord-015306-us58wwmp 4241 26 challenge challenge NN cord-015306-us58wwmp 4241 27 and and CC cord-015306-us58wwmp 4241 28 results result NNS cord-015306-us58wwmp 4241 29 in in IN cord-015306-us58wwmp 4241 30 adverse adverse JJ cord-015306-us58wwmp 4241 31 graft graft NN cord-015306-us58wwmp 4241 32 outcome outcome NN cord-015306-us58wwmp 4241 33 . . . cord-015306-us58wwmp 4242 1 Methods method NNS cord-015306-us58wwmp 4242 2 : : : cord-015306-us58wwmp 4243 1 Seventy seventy CD cord-015306-us58wwmp 4243 2 four four CD cord-015306-us58wwmp 4243 3 kidney kidney NN cord-015306-us58wwmp 4243 4 transplanted transplant VBD cord-015306-us58wwmp 4243 5 children child NNS cord-015306-us58wwmp 4243 6 without without IN cord-015306-us58wwmp 4243 7 any any DT cord-015306-us58wwmp 4243 8 shown show VBN cord-015306-us58wwmp 4243 9 HLA HLA NNP cord-015306-us58wwmp 4243 10 antibody antibody NN cord-015306-us58wwmp 4243 11 in in IN cord-015306-us58wwmp 4243 12 the the DT cord-015306-us58wwmp 4243 13 pre pre JJ cord-015306-us58wwmp 4243 14 - - JJ cord-015306-us58wwmp 4243 15 transplant transplant JJ cord-015306-us58wwmp 4243 16 period period NN cord-015306-us58wwmp 4243 17 were be VBD cord-015306-us58wwmp 4243 18 enrolled enrol VBN cord-015306-us58wwmp 4243 19 in in IN cord-015306-us58wwmp 4243 20 the the DT cord-015306-us58wwmp 4243 21 study study NN cord-015306-us58wwmp 4243 22 . . . cord-015306-us58wwmp 4244 1 Their -PRON- PRP$ cord-015306-us58wwmp 4244 2 anti anti JJ cord-015306-us58wwmp 4244 3 HLA HLA NNP cord-015306-us58wwmp 4244 4 antibody antibody NN cord-015306-us58wwmp 4244 5 status status NN cord-015306-us58wwmp 4244 6 was be VBD cord-015306-us58wwmp 4244 7 checked check VBN cord-015306-us58wwmp 4244 8 by by IN cord-015306-us58wwmp 4244 9 Luminex Luminex NNP cord-015306-us58wwmp 4244 10 during during IN cord-015306-us58wwmp 4244 11 post post JJ cord-015306-us58wwmp 4244 12 transplant transplant NN cord-015306-us58wwmp 4244 13 period period NN cord-015306-us58wwmp 4244 14 and and CC cord-015306-us58wwmp 4244 15 its -PRON- PRP$ cord-015306-us58wwmp 4244 16 relation relation NN cord-015306-us58wwmp 4244 17 with with IN cord-015306-us58wwmp 4244 18 the the DT cord-015306-us58wwmp 4244 19 graft graft NN cord-015306-us58wwmp 4244 20 function function NN cord-015306-us58wwmp 4244 21 and and CC cord-015306-us58wwmp 4244 22 prognosis prognosis NN cord-015306-us58wwmp 4244 23 of of IN cord-015306-us58wwmp 4244 24 the the DT cord-015306-us58wwmp 4244 25 patients patient NNS cord-015306-us58wwmp 4244 26 is be VBZ cord-015306-us58wwmp 4244 27 studied study VBN cord-015306-us58wwmp 4244 28 . . . cord-015306-us58wwmp 4245 1 Results result NNS cord-015306-us58wwmp 4245 2 : : : cord-015306-us58wwmp 4246 1 Mean mean JJ cord-015306-us58wwmp 4246 2 age age NN cord-015306-us58wwmp 4246 3 of of IN cord-015306-us58wwmp 4246 4 the the DT cord-015306-us58wwmp 4246 5 patients patient NNS cord-015306-us58wwmp 4246 6 was be VBD cord-015306-us58wwmp 4246 7 13.5±5.2 13.5±5.2 CD cord-015306-us58wwmp 4246 8 years year NNS cord-015306-us58wwmp 4246 9 . . . cord-015306-us58wwmp 4247 1 Mean mean JJ cord-015306-us58wwmp 4247 2 follow follow NN cord-015306-us58wwmp 4247 3 - - HYPH cord-015306-us58wwmp 4247 4 up up NN cord-015306-us58wwmp 4247 5 time time NN cord-015306-us58wwmp 4247 6 was be VBD cord-015306-us58wwmp 4247 7 3.8±1.1 3.8±1.1 CD cord-015306-us58wwmp 4247 8 years year NNS cord-015306-us58wwmp 4247 9 . . . cord-015306-us58wwmp 4248 1 Pre pre JJ cord-015306-us58wwmp 4248 2 - - JJ cord-015306-us58wwmp 4248 3 transplant transplant NN cord-015306-us58wwmp 4248 4 cytotoxicity cytotoxicity NN cord-015306-us58wwmp 4248 5 tests test NNS cord-015306-us58wwmp 4248 6 and and CC cord-015306-us58wwmp 4248 7 PRA PRA NNP cord-015306-us58wwmp 4248 8 was be VBD cord-015306-us58wwmp 4248 9 negative negative JJ cord-015306-us58wwmp 4248 10 in in IN cord-015306-us58wwmp 4248 11 all all DT cord-015306-us58wwmp 4248 12 patients patient NNS cord-015306-us58wwmp 4248 13 . . . cord-015306-us58wwmp 4249 1 Nine nine CD cord-015306-us58wwmp 4249 2 ( ( -LRB- cord-015306-us58wwmp 4249 3 12.1 12.1 CD cord-015306-us58wwmp 4249 4 % % NN cord-015306-us58wwmp 4249 5 ) ) -RRB- cord-015306-us58wwmp 4249 6 patients patient NNS cord-015306-us58wwmp 4249 7 were be VBD cord-015306-us58wwmp 4249 8 found find VBN cord-015306-us58wwmp 4249 9 to to TO cord-015306-us58wwmp 4249 10 have have VB cord-015306-us58wwmp 4249 11 anti anti NNP cord-015306-us58wwmp 4249 12 HLA HLA NNP cord-015306-us58wwmp 4249 13 antibodies antibody NNS cord-015306-us58wwmp 4249 14 after after IN cord-015306-us58wwmp 4249 15 kidney kidney NN cord-015306-us58wwmp 4249 16 transplantation transplantation NN cord-015306-us58wwmp 4249 17 . . . cord-015306-us58wwmp 4250 1 Mean mean JJ cord-015306-us58wwmp 4250 2 time time NN cord-015306-us58wwmp 4250 3 for for IN cord-015306-us58wwmp 4250 4 the the DT cord-015306-us58wwmp 4250 5 detection detection NN cord-015306-us58wwmp 4250 6 of of IN cord-015306-us58wwmp 4250 7 antibodies antibody NNS cord-015306-us58wwmp 4250 8 was be VBD cord-015306-us58wwmp 4250 9 found find VBN cord-015306-us58wwmp 4250 10 as as IN cord-015306-us58wwmp 4250 11 11±4.8 11±4.8 CD cord-015306-us58wwmp 4250 12 months month NNS cord-015306-us58wwmp 4250 13 . . . cord-015306-us58wwmp 4251 1 Patients patient NNS cord-015306-us58wwmp 4251 2 with with IN cord-015306-us58wwmp 4251 3 anti anti NNP cord-015306-us58wwmp 4251 4 HLA HLA NNP cord-015306-us58wwmp 4251 5 antibodies antibody NNS cord-015306-us58wwmp 4251 6 were be VBD cord-015306-us58wwmp 4251 7 similar similar JJ cord-015306-us58wwmp 4251 8 with with IN cord-015306-us58wwmp 4251 9 patients patient NNS cord-015306-us58wwmp 4251 10 without without IN cord-015306-us58wwmp 4251 11 antibodies antibody NNS cord-015306-us58wwmp 4251 12 in in IN cord-015306-us58wwmp 4251 13 the the DT cord-015306-us58wwmp 4251 14 terms term NNS cord-015306-us58wwmp 4251 15 of of IN cord-015306-us58wwmp 4251 16 age age NN cord-015306-us58wwmp 4251 17 , , , cord-015306-us58wwmp 4251 18 sex sex NN cord-015306-us58wwmp 4251 19 , , , cord-015306-us58wwmp 4251 20 HLA HLA NNP cord-015306-us58wwmp 4251 21 mismatch mismatch NN cord-015306-us58wwmp 4251 22 , , , cord-015306-us58wwmp 4251 23 transfusions transfusion NNS cord-015306-us58wwmp 4251 24 and and CC cord-015306-us58wwmp 4251 25 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 4251 26 drugs drug NNS cord-015306-us58wwmp 4251 27 as as RB cord-015306-us58wwmp 4251 28 well well RB cord-015306-us58wwmp 4251 29 as as IN cord-015306-us58wwmp 4251 30 the the DT cord-015306-us58wwmp 4251 31 presence presence NN cord-015306-us58wwmp 4251 32 of of IN cord-015306-us58wwmp 4251 33 viral viral JJ cord-015306-us58wwmp 4251 34 infections infection NNS cord-015306-us58wwmp 4251 35 . . . cord-015306-us58wwmp 4252 1 Mean mean JJ cord-015306-us58wwmp 4252 2 serum serum NN cord-015306-us58wwmp 4252 3 creatinine creatinine NN cord-015306-us58wwmp 4252 4 level level NN cord-015306-us58wwmp 4252 5 was be VBD cord-015306-us58wwmp 4252 6 found find VBN cord-015306-us58wwmp 4252 7 to to TO cord-015306-us58wwmp 4252 8 be be VB cord-015306-us58wwmp 4252 9 higher high JJR cord-015306-us58wwmp 4252 10 in in IN cord-015306-us58wwmp 4252 11 patients patient NNS cord-015306-us58wwmp 4252 12 with with IN cord-015306-us58wwmp 4252 13 anti anti NNP cord-015306-us58wwmp 4252 14 HLA HLA NNP cord-015306-us58wwmp 4252 15 antibodies antibody NNS cord-015306-us58wwmp 4252 16 . . . cord-015306-us58wwmp 4253 1 The the DT cord-015306-us58wwmp 4253 2 antibody antibody NN cord-015306-us58wwmp 4253 3 mediated mediate VBD cord-015306-us58wwmp 4253 4 rejection rejection NN cord-015306-us58wwmp 4253 5 rate rate NN cord-015306-us58wwmp 4253 6 was be VBD cord-015306-us58wwmp 4253 7 found find VBN cord-015306-us58wwmp 4253 8 to to TO cord-015306-us58wwmp 4253 9 be be VB cord-015306-us58wwmp 4253 10 7.2 7.2 CD cord-015306-us58wwmp 4253 11 % % NN cord-015306-us58wwmp 4253 12 ( ( -LRB- cord-015306-us58wwmp 4253 13 5/65 5/65 CD cord-015306-us58wwmp 4253 14 ) ) -RRB- cord-015306-us58wwmp 4253 15 in in IN cord-015306-us58wwmp 4253 16 patients patient NNS cord-015306-us58wwmp 4253 17 without without IN cord-015306-us58wwmp 4253 18 anti anti NNP cord-015306-us58wwmp 4253 19 HLA HLA NNP cord-015306-us58wwmp 4253 20 antibodies antibody NNS cord-015306-us58wwmp 4253 21 while while IN cord-015306-us58wwmp 4253 22 it -PRON- PRP cord-015306-us58wwmp 4253 23 was be VBD cord-015306-us58wwmp 4253 24 55.1 55.1 CD cord-015306-us58wwmp 4253 25 % % NN cord-015306-us58wwmp 4253 26 ( ( -LRB- cord-015306-us58wwmp 4253 27 5/9 5/9 CD cord-015306-us58wwmp 4253 28 ) ) -RRB- cord-015306-us58wwmp 4253 29 and and CC cord-015306-us58wwmp 4253 30 remained remain VBD cord-015306-us58wwmp 4253 31 dialysis dialysis NN cord-015306-us58wwmp 4253 32 dependent dependent JJ cord-015306-us58wwmp 4253 33 . . . cord-015306-us58wwmp 4254 1 All all DT cord-015306-us58wwmp 4254 2 6 6 CD cord-015306-us58wwmp 4254 3 were be VBD cord-015306-us58wwmp 4254 4 dialysis dialysis NN cord-015306-us58wwmp 4254 5 dependent dependent JJ cord-015306-us58wwmp 4254 6 by by IN cord-015306-us58wwmp 4254 7 6 6 CD cord-015306-us58wwmp 4254 8 months month NNS cord-015306-us58wwmp 4254 9 post post NN cord-015306-us58wwmp 4254 10 diagnosis diagnosis NN cord-015306-us58wwmp 4254 11 . . . cord-015306-us58wwmp 4255 1 Time time NN cord-015306-us58wwmp 4255 2 from from IN cord-015306-us58wwmp 4255 3 ANCA ANCA NNP cord-015306-us58wwmp 4255 4 GN GN NNP cord-015306-us58wwmp 4255 5 diagnosis diagnosis NN cord-015306-us58wwmp 4255 6 to to IN cord-015306-us58wwmp 4255 7 kidney kidney NN cord-015306-us58wwmp 4255 8 transplant transplant NN cord-015306-us58wwmp 4255 9 ( ( -LRB- cord-015306-us58wwmp 4255 10 Mean±SD Mean±SD NNP cord-015306-us58wwmp 4255 11 ) ) -RRB- cord-015306-us58wwmp 4255 12 was be VBD cord-015306-us58wwmp 4255 13 31±12 31±12 CD cord-015306-us58wwmp 4255 14 months month NNS cord-015306-us58wwmp 4256 1 ( ( -LRB- cord-015306-us58wwmp 4256 2 range range NNP cord-015306-us58wwmp 4256 3 17 17 CD cord-015306-us58wwmp 4256 4 -48 -48 NNP cord-015306-us58wwmp 4256 5 months month NNS cord-015306-us58wwmp 4256 6 ) ) -RRB- cord-015306-us58wwmp 4256 7 . . . cord-015306-us58wwmp 4257 1 All all DT cord-015306-us58wwmp 4257 2 patients patient NNS cord-015306-us58wwmp 4257 3 received receive VBD cord-015306-us58wwmp 4257 4 induction induction NN cord-015306-us58wwmp 4257 5 therapy therapy NN cord-015306-us58wwmp 4257 6 and and CC cord-015306-us58wwmp 4257 7 maintenance maintenance NN cord-015306-us58wwmp 4257 8 immunosuppression immunosuppression NN cord-015306-us58wwmp 4257 9 with with IN cord-015306-us58wwmp 4257 10 prednisone prednisone NNP cord-015306-us58wwmp 4257 11 , , , cord-015306-us58wwmp 4257 12 mycophenolate mycophenolate NNP cord-015306-us58wwmp 4257 13 mofetil mofetil NNP cord-015306-us58wwmp 4257 14 , , , cord-015306-us58wwmp 4257 15 and and CC cord-015306-us58wwmp 4257 16 tacrolimus tacrolimus NNP cord-015306-us58wwmp 4257 17 . . . cord-015306-us58wwmp 4258 1 Median median JJ cord-015306-us58wwmp 4258 2 duration duration NN cord-015306-us58wwmp 4258 3 of of IN cord-015306-us58wwmp 4258 4 follow follow VB cord-015306-us58wwmp 4258 5 up up RP cord-015306-us58wwmp 4258 6 post post NN cord-015306-us58wwmp 4258 7 transplantation transplantation NN cord-015306-us58wwmp 4258 8 was be VBD cord-015306-us58wwmp 4258 9 3.5 3.5 CD cord-015306-us58wwmp 4258 10 years year NNS cord-015306-us58wwmp 4258 11 ( ( -LRB- cord-015306-us58wwmp 4258 12 range range VBP cord-015306-us58wwmp 4258 13 1.25 1.25 CD cord-015306-us58wwmp 4258 14 -6.9 -6.9 NN cord-015306-us58wwmp 4258 15 ) ) -RRB- cord-015306-us58wwmp 4258 16 . . . cord-015306-us58wwmp 4259 1 eGFR egfr XX cord-015306-us58wwmp 4260 1 at at IN cord-015306-us58wwmp 4260 2 last last JJ cord-015306-us58wwmp 4260 3 follow follow NN cord-015306-us58wwmp 4260 4 up up RP cord-015306-us58wwmp 4260 5 was be VBD cord-015306-us58wwmp 4260 6 71.9 71.9 CD cord-015306-us58wwmp 4260 7 ± ± CD cord-015306-us58wwmp 4260 8 34.7 34.7 CD cord-015306-us58wwmp 4260 9 ml/ ml/ JJ cord-015306-us58wwmp 4261 1 min/1.73 min/1.73 JJ cord-015306-us58wwmp 4261 2 m m CD cord-015306-us58wwmp 4261 3 2 2 CD cord-015306-us58wwmp 4262 1 ( ( -LRB- cord-015306-us58wwmp 4262 2 range range VBP cord-015306-us58wwmp 4262 3 5.7 5.7 CD cord-015306-us58wwmp 4262 4 -100.5 -100.5 NFP cord-015306-us58wwmp 4262 5 ) ) -RRB- cord-015306-us58wwmp 4262 6 . . . cord-015306-us58wwmp 4263 1 1 1 CD cord-015306-us58wwmp 4263 2 patient patient NN cord-015306-us58wwmp 4263 3 lost lose VBD cord-015306-us58wwmp 4263 4 her -PRON- PRP$ cord-015306-us58wwmp 4263 5 transplant transplant NN cord-015306-us58wwmp 4263 6 to to IN cord-015306-us58wwmp 4263 7 biopsy biopsy NN cord-015306-us58wwmp 4263 8 - - HYPH cord-015306-us58wwmp 4263 9 proven prove VBN cord-015306-us58wwmp 4263 10 , , , cord-015306-us58wwmp 4263 11 severe severe JJ cord-015306-us58wwmp 4263 12 acute acute JJ cord-015306-us58wwmp 4263 13 cellular cellular JJ cord-015306-us58wwmp 4263 14 rejection rejection NN cord-015306-us58wwmp 4263 15 due due IN cord-015306-us58wwmp 4263 16 to to TO cord-015306-us58wwmp 4263 17 complete complete VB cord-015306-us58wwmp 4263 18 non non JJ cord-015306-us58wwmp 4263 19 - - JJ cord-015306-us58wwmp 4263 20 adherence adherence NN cord-015306-us58wwmp 4263 21 to to IN cord-015306-us58wwmp 4263 22 medications medication NNS cord-015306-us58wwmp 4263 23 after after IN cord-015306-us58wwmp 4263 24 21 21 CD cord-015306-us58wwmp 4263 25 months month NNS cord-015306-us58wwmp 4263 26 of of IN cord-015306-us58wwmp 4263 27 stable stable JJ cord-015306-us58wwmp 4263 28 transplant transplant NN cord-015306-us58wwmp 4263 29 function function NN cord-015306-us58wwmp 4263 30 . . . cord-015306-us58wwmp 4264 1 No no DT cord-015306-us58wwmp 4264 2 patient patient NN cord-015306-us58wwmp 4264 3 had have VBD cord-015306-us58wwmp 4264 4 recurrence recurrence NN cord-015306-us58wwmp 4264 5 of of IN cord-015306-us58wwmp 4264 6 vasculitis vasculitis NN cord-015306-us58wwmp 4264 7 . . . cord-015306-us58wwmp 4265 1 Conclusion conclusion NN cord-015306-us58wwmp 4265 2 : : : cord-015306-us58wwmp 4265 3 Short short JJ cord-015306-us58wwmp 4265 4 - - HYPH cord-015306-us58wwmp 4265 5 term term NN cord-015306-us58wwmp 4265 6 patient patient NN cord-015306-us58wwmp 4265 7 and and CC cord-015306-us58wwmp 4265 8 allograft allograft NN cord-015306-us58wwmp 4265 9 survival survival NN cord-015306-us58wwmp 4265 10 in in IN cord-015306-us58wwmp 4265 11 paediatric paediatric JJ cord-015306-us58wwmp 4265 12 patients patient NNS cord-015306-us58wwmp 4265 13 with with IN cord-015306-us58wwmp 4265 14 ESKD ESKD NNP cord-015306-us58wwmp 4265 15 secondary secondary JJ cord-015306-us58wwmp 4265 16 to to IN cord-015306-us58wwmp 4265 17 ANCA ANCA NNP cord-015306-us58wwmp 4265 18 GN GN NNP cord-015306-us58wwmp 4265 19 is be VBZ cord-015306-us58wwmp 4265 20 excellent excellent JJ cord-015306-us58wwmp 4265 21 despite despite IN cord-015306-us58wwmp 4265 22 aggressive aggressive JJ cord-015306-us58wwmp 4265 23 disease disease NN cord-015306-us58wwmp 4265 24 , , , cord-015306-us58wwmp 4265 25 with with IN cord-015306-us58wwmp 4265 26 no no DT cord-015306-us58wwmp 4265 27 recurrence recurrence NN cord-015306-us58wwmp 4265 28 of of IN cord-015306-us58wwmp 4265 29 vasculitis vasculitis JJ cord-015306-us58wwmp 4265 30 post post NN cord-015306-us58wwmp 4265 31 transplant transplant NN cord-015306-us58wwmp 4265 32 . . . cord-015306-us58wwmp 4266 1 Abstract abstract JJ cord-015306-us58wwmp 4266 2 # # NN cord-015306-us58wwmp 4266 3 P p NN cord-015306-us58wwmp 4266 4 - - HYPH cord-015306-us58wwmp 4266 5 SAT429 SAT429 NNP cord-015306-us58wwmp 4266 6 En En NNP cord-015306-us58wwmp 4266 7 - - HYPH cord-015306-us58wwmp 4266 8 bloc bloc NN cord-015306-us58wwmp 4266 9 kidneys kidney NNS cord-015306-us58wwmp 4266 10 from from IN cord-015306-us58wwmp 4266 11 infant infant JJ cord-015306-us58wwmp 4266 12 donors donor NNS cord-015306-us58wwmp 4266 13 less less JJR cord-015306-us58wwmp 4266 14 than than IN cord-015306-us58wwmp 4266 15 5 5 CD cord-015306-us58wwmp 4266 16 kg kg NN cord-015306-us58wwmp 4266 17 transplantation transplantation NN cord-015306-us58wwmp 4266 18 into into IN cord-015306-us58wwmp 4266 19 pediatric pediatric JJ cord-015306-us58wwmp 4266 20 recipients recipient NNS cord-015306-us58wwmp 4266 21 at at IN cord-015306-us58wwmp 4266 22 school school NN cord-015306-us58wwmp 4266 23 age age NN cord-015306-us58wwmp 4266 24 Objective Objective NNP cord-015306-us58wwmp 4266 25 : : : cord-015306-us58wwmp 4266 26 Given give VBN cord-015306-us58wwmp 4266 27 the the DT cord-015306-us58wwmp 4266 28 shortage shortage NN cord-015306-us58wwmp 4266 29 of of IN cord-015306-us58wwmp 4266 30 donor donor NN cord-015306-us58wwmp 4266 31 kidneys kidney NNS cord-015306-us58wwmp 4266 32 in in IN cord-015306-us58wwmp 4266 33 China China NNP cord-015306-us58wwmp 4266 34 , , , cord-015306-us58wwmp 4266 35 the the DT cord-015306-us58wwmp 4266 36 use use NN cord-015306-us58wwmp 4266 37 of of IN cord-015306-us58wwmp 4266 38 grafts graft NNS cord-015306-us58wwmp 4266 39 from from IN cord-015306-us58wwmp 4266 40 deceased deceased JJ cord-015306-us58wwmp 4266 41 infant infant NN cord-015306-us58wwmp 4266 42 donors donor NNS cord-015306-us58wwmp 4266 43 ( ( -LRB- cord-015306-us58wwmp 4266 44 weight weight NN cord-015306-us58wwmp 4266 45 < < XX cord-015306-us58wwmp 4266 46 5 5 CD cord-015306-us58wwmp 4266 47 kg kg NNP cord-015306-us58wwmp 4266 48 ) ) -RRB- cord-015306-us58wwmp 4266 49 is be VBZ cord-015306-us58wwmp 4266 50 a a DT cord-015306-us58wwmp 4266 51 potential potential JJ cord-015306-us58wwmp 4266 52 approach approach NN cord-015306-us58wwmp 4266 53 to to TO cord-015306-us58wwmp 4266 54 expand expand VB cord-015306-us58wwmp 4266 55 the the DT cord-015306-us58wwmp 4266 56 donor donor NN cord-015306-us58wwmp 4266 57 pool pool NN cord-015306-us58wwmp 4266 58 . . . cord-015306-us58wwmp 4267 1 In in IN cord-015306-us58wwmp 4267 2 this this DT cord-015306-us58wwmp 4267 3 study study NN cord-015306-us58wwmp 4267 4 , , , cord-015306-us58wwmp 4267 5 we -PRON- PRP cord-015306-us58wwmp 4267 6 reviewed review VBD cord-015306-us58wwmp 4267 7 the the DT cord-015306-us58wwmp 4267 8 results result NNS cord-015306-us58wwmp 4267 9 of of IN cord-015306-us58wwmp 4267 10 the the DT cord-015306-us58wwmp 4267 11 first first JJ cord-015306-us58wwmp 4267 12 cohort cohort NN cord-015306-us58wwmp 4267 13 of of IN cord-015306-us58wwmp 4267 14 en en NNP cord-015306-us58wwmp 4267 15 bloc bloc NNP cord-015306-us58wwmp 4267 16 kidney kidney NN cord-015306-us58wwmp 4267 17 transplantation transplantation NN cord-015306-us58wwmp 4267 18 of of IN cord-015306-us58wwmp 4267 19 infant infant JJ cord-015306-us58wwmp 4267 20 donors donor NNS cord-015306-us58wwmp 4267 21 to to IN cord-015306-us58wwmp 4267 22 pediatric pediatric JJ cord-015306-us58wwmp 4267 23 recipients recipient NNS cord-015306-us58wwmp 4267 24 at at IN cord-015306-us58wwmp 4267 25 school school NN cord-015306-us58wwmp 4267 26 age age NN cord-015306-us58wwmp 4267 27 in in IN cord-015306-us58wwmp 4267 28 our -PRON- PRP$ cord-015306-us58wwmp 4267 29 center center NN cord-015306-us58wwmp 4267 30 . . . cord-015306-us58wwmp 4268 1 Methods method NNS cord-015306-us58wwmp 4268 2 : : : cord-015306-us58wwmp 4269 1 From from IN cord-015306-us58wwmp 4269 2 February February NNP cord-015306-us58wwmp 4269 3 2012 2012 CD cord-015306-us58wwmp 4269 4 to to IN cord-015306-us58wwmp 4269 5 March March NNP cord-015306-us58wwmp 4269 6 2013 2013 CD cord-015306-us58wwmp 4269 7 , , , cord-015306-us58wwmp 4269 8 4 4 CD cord-015306-us58wwmp 4269 9 infant infant NN cord-015306-us58wwmp 4269 10 en en IN cord-015306-us58wwmp 4269 11 bloc bloc NNP cord-015306-us58wwmp 4269 12 kidney kidney NN cord-015306-us58wwmp 4269 13 transplants transplant NNS cord-015306-us58wwmp 4269 14 in in IN cord-015306-us58wwmp 4269 15 pediatric pediatric JJ cord-015306-us58wwmp 4269 16 recipients recipient NNS cord-015306-us58wwmp 4269 17 were be VBD cord-015306-us58wwmp 4269 18 performed perform VBN cord-015306-us58wwmp 4269 19 in in IN cord-015306-us58wwmp 4269 20 our -PRON- PRP$ cord-015306-us58wwmp 4269 21 center center NN cord-015306-us58wwmp 4269 22 . . . cord-015306-us58wwmp 4270 1 En en IN cord-015306-us58wwmp 4270 2 bloc bloc NNP cord-015306-us58wwmp 4270 3 kidneys kidney NNS cord-015306-us58wwmp 4270 4 from from IN cord-015306-us58wwmp 4270 5 4 4 CD cord-015306-us58wwmp 4270 6 infant infant NN cord-015306-us58wwmp 4270 7 donors donor NNS cord-015306-us58wwmp 4270 8 ( ( -LRB- cord-015306-us58wwmp 4270 9 Maastricht Maastricht NNP cord-015306-us58wwmp 4270 10 Category Category NNP cord-015306-us58wwmp 4270 11 III III NNP cord-015306-us58wwmp 4270 12 ) ) -RRB- cord-015306-us58wwmp 4270 13 who who WP cord-015306-us58wwmp 4270 14 died die VBD cord-015306-us58wwmp 4270 15 of of IN cord-015306-us58wwmp 4270 16 severe severe JJ cord-015306-us58wwmp 4270 17 congenital congenital JJ cord-015306-us58wwmp 4270 18 disease disease NN cord-015306-us58wwmp 4270 19 were be VBD cord-015306-us58wwmp 4270 20 recovered recover VBN cord-015306-us58wwmp 4270 21 and and CC cord-015306-us58wwmp 4270 22 donated donate VBN cord-015306-us58wwmp 4270 23 to to IN cord-015306-us58wwmp 4270 24 the the DT cord-015306-us58wwmp 4270 25 Red Red NNP cord-015306-us58wwmp 4270 26 Cross Cross NNP cord-015306-us58wwmp 4270 27 Society Society NNP cord-015306-us58wwmp 4270 28 of of IN cord-015306-us58wwmp 4270 29 Tianjin Tianjin NNP cord-015306-us58wwmp 4270 30 and and CC cord-015306-us58wwmp 4270 31 allocated allocate VBN cord-015306-us58wwmp 4270 32 to to IN cord-015306-us58wwmp 4270 33 our -PRON- PRP$ cord-015306-us58wwmp 4270 34 center center NN cord-015306-us58wwmp 4270 35 by by IN cord-015306-us58wwmp 4270 36 China China NNP cord-015306-us58wwmp 4270 37 Organ Organ NNP cord-015306-us58wwmp 4270 38 Transplant Transplant NNP cord-015306-us58wwmp 4270 39 Response Response NNP cord-015306-us58wwmp 4270 40 System System NNP cord-015306-us58wwmp 4270 41 ( ( -LRB- cord-015306-us58wwmp 4270 42 CORTS CORTS NNP cord-015306-us58wwmp 4270 43 ) ) -RRB- cord-015306-us58wwmp 4270 44 . . . cord-015306-us58wwmp 4271 1 Donor donor NN cord-015306-us58wwmp 4271 2 age age NN cord-015306-us58wwmp 4271 3 ranged range VBD cord-015306-us58wwmp 4271 4 from from IN cord-015306-us58wwmp 4271 5 33 33 CD cord-015306-us58wwmp 4271 6 to to TO cord-015306-us58wwmp 4271 7 56 56 CD cord-015306-us58wwmp 4271 8 days day NNS cord-015306-us58wwmp 4271 9 with with IN cord-015306-us58wwmp 4271 10 weight weight NN cord-015306-us58wwmp 4271 11 ranging range VBG cord-015306-us58wwmp 4271 12 from from IN cord-015306-us58wwmp 4271 13 2.5 2.5 CD cord-015306-us58wwmp 4271 14 to to IN cord-015306-us58wwmp 4271 15 5.0 5.0 CD cord-015306-us58wwmp 4271 16 kg kg NNS cord-015306-us58wwmp 4271 17 . . . cord-015306-us58wwmp 4272 1 Recipients recipient NNS cord-015306-us58wwmp 4272 2 included include VBD cord-015306-us58wwmp 4272 3 2 2 CD cord-015306-us58wwmp 4272 4 females female NNS cord-015306-us58wwmp 4272 5 and and CC cord-015306-us58wwmp 4272 6 2 2 CD cord-015306-us58wwmp 4272 7 males male NNS cord-015306-us58wwmp 4272 8 with with IN cord-015306-us58wwmp 4272 9 age age NN cord-015306-us58wwmp 4272 10 ranging range VBG cord-015306-us58wwmp 4272 11 from from IN cord-015306-us58wwmp 4272 12 5 5 CD cord-015306-us58wwmp 4272 13 to to TO cord-015306-us58wwmp 4272 14 11 11 CD cord-015306-us58wwmp 4272 15 yr yr NN cord-015306-us58wwmp 4272 16 . . . cord-015306-us58wwmp 4273 1 The the DT cord-015306-us58wwmp 4273 2 en en FW cord-015306-us58wwmp 4273 3 bloc bloc NNP cord-015306-us58wwmp 4273 4 graft graft NN cord-015306-us58wwmp 4273 5 was be VBD cord-015306-us58wwmp 4273 6 implanted implant VBN cord-015306-us58wwmp 4273 7 extraperitoneally extraperitoneally RB cord-015306-us58wwmp 4273 8 in in IN cord-015306-us58wwmp 4273 9 the the DT cord-015306-us58wwmp 4273 10 right right JJ cord-015306-us58wwmp 4273 11 iliac iliac JJ cord-015306-us58wwmp 4273 12 fossa fossa NN cord-015306-us58wwmp 4273 13 . . . cord-015306-us58wwmp 4274 1 The the DT cord-015306-us58wwmp 4274 2 distal distal JJ cord-015306-us58wwmp 4274 3 end end NN cord-015306-us58wwmp 4274 4 of of IN cord-015306-us58wwmp 4274 5 the the DT cord-015306-us58wwmp 4274 6 donor donor NN cord-015306-us58wwmp 4275 1 aorta aorta NNP cord-015306-us58wwmp 4275 2 was be VBD cord-015306-us58wwmp 4275 3 anastomosed anastomosed JJ cord-015306-us58wwmp 4275 4 end end NN cord-015306-us58wwmp 4275 5 - - HYPH cord-015306-us58wwmp 4275 6 to to IN cord-015306-us58wwmp 4275 7 - - HYPH cord-015306-us58wwmp 4275 8 end end NN cord-015306-us58wwmp 4275 9 to to IN cord-015306-us58wwmp 4275 10 the the DT cord-015306-us58wwmp 4275 11 internal internal JJ cord-015306-us58wwmp 4275 12 iliac iliac NNP cord-015306-us58wwmp 4275 13 artery artery NN cord-015306-us58wwmp 4275 14 , , , cord-015306-us58wwmp 4275 15 while while IN cord-015306-us58wwmp 4275 16 the the DT cord-015306-us58wwmp 4275 17 donor donor NN cord-015306-us58wwmp 4275 18 vena vena FW cord-015306-us58wwmp 4275 19 cava cava NNP cord-015306-us58wwmp 4275 20 was be VBD cord-015306-us58wwmp 4275 21 anastomosed anastomose VBN cord-015306-us58wwmp 4275 22 to to IN cord-015306-us58wwmp 4275 23 the the DT cord-015306-us58wwmp 4275 24 external external JJ cord-015306-us58wwmp 4275 25 iliac iliac NN cord-015306-us58wwmp 4275 26 vein vein NN cord-015306-us58wwmp 4275 27 . . . cord-015306-us58wwmp 4276 1 The the DT cord-015306-us58wwmp 4276 2 donor donor NN cord-015306-us58wwmp 4276 3 ureters ureter NNS cord-015306-us58wwmp 4276 4 were be VBD cord-015306-us58wwmp 4276 5 implanted implant VBN cord-015306-us58wwmp 4276 6 separately separately RB cord-015306-us58wwmp 4276 7 onto onto IN cord-015306-us58wwmp 4276 8 the the DT cord-015306-us58wwmp 4276 9 bladder bladder NN cord-015306-us58wwmp 4276 10 with with IN cord-015306-us58wwmp 4276 11 double double JJ cord-015306-us58wwmp 4276 12 - - HYPH cord-015306-us58wwmp 4276 13 J j NN cord-015306-us58wwmp 4276 14 stents stent NNS cord-015306-us58wwmp 4276 15 placement placement NN cord-015306-us58wwmp 4276 16 . . . cord-015306-us58wwmp 4277 1 After after IN cord-015306-us58wwmp 4277 2 the the DT cord-015306-us58wwmp 4277 3 operation operation NN cord-015306-us58wwmp 4277 4 , , , cord-015306-us58wwmp 4277 5 the the DT cord-015306-us58wwmp 4277 6 recipients recipient NNS cord-015306-us58wwmp 4277 7 received receive VBD cord-015306-us58wwmp 4277 8 basiliximab basiliximab NNS cord-015306-us58wwmp 4277 9 as as IN cord-015306-us58wwmp 4277 10 an an DT cord-015306-us58wwmp 4277 11 induction induction NN cord-015306-us58wwmp 4277 12 therapy therapy NN cord-015306-us58wwmp 4277 13 . . . cord-015306-us58wwmp 4278 1 Maintenance maintenance NN cord-015306-us58wwmp 4278 2 immunosuppression immunosuppression NN cord-015306-us58wwmp 4278 3 consisted consist VBD cord-015306-us58wwmp 4278 4 of of IN cord-015306-us58wwmp 4278 5 tacrolimus tacrolimus NN cord-015306-us58wwmp 4278 6 and and CC cord-015306-us58wwmp 4278 7 Myfortic Myfortic NNP cord-015306-us58wwmp 4278 8 . . . cord-015306-us58wwmp 4279 1 Prophylactic prophylactic JJ cord-015306-us58wwmp 4279 2 anticoagulation anticoagulation NN cord-015306-us58wwmp 4279 3 with with IN cord-015306-us58wwmp 4279 4 heparin heparin NN cord-015306-us58wwmp 4279 5 was be VBD cord-015306-us58wwmp 4279 6 used use VBN cord-015306-us58wwmp 4279 7 for for IN cord-015306-us58wwmp 4279 8 the the DT cord-015306-us58wwmp 4279 9 first first JJ cord-015306-us58wwmp 4279 10 week week NN cord-015306-us58wwmp 4279 11 after after IN cord-015306-us58wwmp 4279 12 transplantation transplantation NN cord-015306-us58wwmp 4279 13 . . . cord-015306-us58wwmp 4280 1 Results result NNS cord-015306-us58wwmp 4280 2 : : : cord-015306-us58wwmp 4281 1 Patient patient JJ cord-015306-us58wwmp 4281 2 survival survival NN cord-015306-us58wwmp 4281 3 was be VBD cord-015306-us58wwmp 4281 4 100 100 CD cord-015306-us58wwmp 4281 5 % % NN cord-015306-us58wwmp 4281 6 . . . cord-015306-us58wwmp 4282 1 Complications complication NNS cord-015306-us58wwmp 4282 2 included include VBD cord-015306-us58wwmp 4282 3 delayed delayed JJ cord-015306-us58wwmp 4282 4 graft graft NN cord-015306-us58wwmp 4282 5 function function NN cord-015306-us58wwmp 4282 6 in in IN cord-015306-us58wwmp 4282 7 1 1 CD cord-015306-us58wwmp 4282 8 patient patient NN cord-015306-us58wwmp 4282 9 ( ( -LRB- cord-015306-us58wwmp 4282 10 managed manage VBN cord-015306-us58wwmp 4282 11 by by IN cord-015306-us58wwmp 4282 12 PD PD NNP cord-015306-us58wwmp 4282 13 for for IN cord-015306-us58wwmp 4282 14 one one CD cord-015306-us58wwmp 4282 15 week week NN cord-015306-us58wwmp 4282 16 ) ) -RRB- cord-015306-us58wwmp 4282 17 , , , cord-015306-us58wwmp 4282 18 urine urine NN cord-015306-us58wwmp 4282 19 leak leak NN cord-015306-us58wwmp 4282 20 in in IN cord-015306-us58wwmp 4282 21 1 1 CD cord-015306-us58wwmp 4282 22 , , , cord-015306-us58wwmp 4282 23 and and CC cord-015306-us58wwmp 4282 24 anticoagulation anticoagulation NN cord-015306-us58wwmp 4282 25 - - HYPH cord-015306-us58wwmp 4282 26 related relate VBN cord-015306-us58wwmp 4282 27 hemorrhage hemorrhage NN cord-015306-us58wwmp 4282 28 in in IN cord-015306-us58wwmp 4282 29 1 1 CD cord-015306-us58wwmp 4282 30 . . . cord-015306-us58wwmp 4283 1 Due due IN cord-015306-us58wwmp 4283 2 to to IN cord-015306-us58wwmp 4283 3 discontinued discontinue VBN cord-015306-us58wwmp 4283 4 anticoagulation anticoagulation NN cord-015306-us58wwmp 4283 5 , , , cord-015306-us58wwmp 4283 6 one one CD cord-015306-us58wwmp 4283 7 graft graft NN cord-015306-us58wwmp 4283 8 was be VBD cord-015306-us58wwmp 4283 9 lost lose VBN cord-015306-us58wwmp 4283 10 early early RB cord-015306-us58wwmp 4283 11 from from IN cord-015306-us58wwmp 4283 12 vascular vascular JJ cord-015306-us58wwmp 4283 13 thrombosis thrombosis NN cord-015306-us58wwmp 4283 14 . . . cord-015306-us58wwmp 4284 1 Of of IN cord-015306-us58wwmp 4284 2 the the DT cord-015306-us58wwmp 4284 3 remaining remain VBG cord-015306-us58wwmp 4284 4 3 3 CD cord-015306-us58wwmp 4284 5 recipients recipient NNS cord-015306-us58wwmp 4284 6 , , , cord-015306-us58wwmp 4284 7 all all DT cord-015306-us58wwmp 4284 8 had have VBD cord-015306-us58wwmp 4284 9 immediate immediate JJ cord-015306-us58wwmp 4284 10 and and CC cord-015306-us58wwmp 4284 11 excellent excellent JJ cord-015306-us58wwmp 4284 12 long long JJ cord-015306-us58wwmp 4284 13 - - HYPH cord-015306-us58wwmp 4284 14 term term NN cord-015306-us58wwmp 4284 15 function function NN cord-015306-us58wwmp 4284 16 with with IN cord-015306-us58wwmp 4284 17 average average JJ cord-015306-us58wwmp 4284 18 creatinine creatinine NN cord-015306-us58wwmp 4284 19 of of IN cord-015306-us58wwmp 4284 20 1.13±0.31 1.13±0.31 CD cord-015306-us58wwmp 4284 21 mg mg NNP cord-015306-us58wwmp 4284 22 / / SYM cord-015306-us58wwmp 4284 23 dL dl NN cord-015306-us58wwmp 4284 24 at at IN cord-015306-us58wwmp 4284 25 5 5 CD cord-015306-us58wwmp 4284 26 months month NNS cord-015306-us58wwmp 4284 27 follow follow NN cord-015306-us58wwmp 4284 28 - - HYPH cord-015306-us58wwmp 4284 29 up up NN cord-015306-us58wwmp 4285 1 ( ( -LRB- cord-015306-us58wwmp 4285 2 range range NNP cord-015306-us58wwmp 4285 3 1 1 CD cord-015306-us58wwmp 4285 4 - - SYM cord-015306-us58wwmp 4285 5 12 12 CD cord-015306-us58wwmp 4285 6 months month NNS cord-015306-us58wwmp 4285 7 ) ) -RRB- cord-015306-us58wwmp 4285 8 . . . cord-015306-us58wwmp 4286 1 Conclusion conclusion NN cord-015306-us58wwmp 4286 2 : : : cord-015306-us58wwmp 4287 1 This this DT cord-015306-us58wwmp 4287 2 is be VBZ cord-015306-us58wwmp 4287 3 the the DT cord-015306-us58wwmp 4287 4 first first JJ cord-015306-us58wwmp 4287 5 report report NN cord-015306-us58wwmp 4287 6 of of IN cord-015306-us58wwmp 4287 7 en en NNP cord-015306-us58wwmp 4287 8 bloc bloc NNP cord-015306-us58wwmp 4287 9 kidney kidney NN cord-015306-us58wwmp 4287 10 transplantation transplantation NN cord-015306-us58wwmp 4287 11 from from IN cord-015306-us58wwmp 4287 12 infant infant JJ cord-015306-us58wwmp 4287 13 donors donor NNS cord-015306-us58wwmp 4287 14 into into IN cord-015306-us58wwmp 4287 15 pediatric pediatric JJ cord-015306-us58wwmp 4287 16 recipients recipient NNS cord-015306-us58wwmp 4287 17 in in IN cord-015306-us58wwmp 4287 18 China China NNP cord-015306-us58wwmp 4287 19 . . . cord-015306-us58wwmp 4288 1 Many many JJ cord-015306-us58wwmp 4288 2 improvements improvement NNS cord-015306-us58wwmp 4288 3 by by IN cord-015306-us58wwmp 4288 4 our -PRON- PRP$ cord-015306-us58wwmp 4288 5 transplant transplant NN cord-015306-us58wwmp 4288 6 teams team NNS cord-015306-us58wwmp 4288 7 had have VBD cord-015306-us58wwmp 4288 8 improved improve VBN cord-015306-us58wwmp 4288 9 the the DT cord-015306-us58wwmp 4288 10 survival survival NN cord-015306-us58wwmp 4288 11 of of IN cord-015306-us58wwmp 4288 12 patients patient NNS cord-015306-us58wwmp 4288 13 and and CC cord-015306-us58wwmp 4288 14 grafts graft NNS cord-015306-us58wwmp 4288 15 . . . cord-015306-us58wwmp 4289 1 Based base VBN cord-015306-us58wwmp 4289 2 on on IN cord-015306-us58wwmp 4289 3 our -PRON- PRP$ cord-015306-us58wwmp 4289 4 experience experience NN cord-015306-us58wwmp 4289 5 , , , cord-015306-us58wwmp 4289 6 albeit albeit IN cord-015306-us58wwmp 4289 7 very very RB cord-015306-us58wwmp 4289 8 limited limited JJ cord-015306-us58wwmp 4289 9 , , , cord-015306-us58wwmp 4289 10 we -PRON- PRP cord-015306-us58wwmp 4289 11 concluded conclude VBD cord-015306-us58wwmp 4289 12 that that IN cord-015306-us58wwmp 4289 13 favorable favorable JJ cord-015306-us58wwmp 4289 14 outcomes outcome NNS cord-015306-us58wwmp 4289 15 can can MD cord-015306-us58wwmp 4289 16 be be VB cord-015306-us58wwmp 4289 17 obtained obtain VBN cord-015306-us58wwmp 4289 18 from from IN cord-015306-us58wwmp 4289 19 en en IN cord-015306-us58wwmp 4289 20 bloc bloc NNP cord-015306-us58wwmp 4289 21 transplantation transplantation NN cord-015306-us58wwmp 4289 22 from from IN cord-015306-us58wwmp 4289 23 infant infant JJ cord-015306-us58wwmp 4289 24 donors donor NNS cord-015306-us58wwmp 4289 25 . . . cord-015306-us58wwmp 4290 1 Objective objective NN cord-015306-us58wwmp 4290 2 : : : cord-015306-us58wwmp 4291 1 To to TO cord-015306-us58wwmp 4291 2 describe describe VB cord-015306-us58wwmp 4291 3 the the DT cord-015306-us58wwmp 4291 4 rates rate NNS cord-015306-us58wwmp 4291 5 and and CC cord-015306-us58wwmp 4291 6 outcomes outcome NNS cord-015306-us58wwmp 4291 7 of of IN cord-015306-us58wwmp 4291 8 renal renal JJ cord-015306-us58wwmp 4291 9 transplantation transplantation NN cord-015306-us58wwmp 4291 10 in in IN cord-015306-us58wwmp 4291 11 children child NNS cord-015306-us58wwmp 4291 12 with with IN cord-015306-us58wwmp 4291 13 intellectual intellectual JJ cord-015306-us58wwmp 4291 14 disability disability NN cord-015306-us58wwmp 4291 15 ( ( -LRB- cord-015306-us58wwmp 4291 16 ID ID NNP cord-015306-us58wwmp 4291 17 ) ) -RRB- cord-015306-us58wwmp 4291 18 . . . cord-015306-us58wwmp 4292 1 Methods method NNS cord-015306-us58wwmp 4292 2 : : : cord-015306-us58wwmp 4293 1 We -PRON- PRP cord-015306-us58wwmp 4293 2 performed perform VBD cord-015306-us58wwmp 4293 3 a a DT cord-015306-us58wwmp 4293 4 retrospective retrospective JJ cord-015306-us58wwmp 4293 5 analysis analysis NN cord-015306-us58wwmp 4293 6 of of IN cord-015306-us58wwmp 4293 7 all all DT cord-015306-us58wwmp 4293 8 children child NNS cord-015306-us58wwmp 4293 9 receiving receive VBG cord-015306-us58wwmp 4293 10 a a DT cord-015306-us58wwmp 4293 11 first first JJ cord-015306-us58wwmp 4293 12 kidney kidney NN cord-015306-us58wwmp 4293 13 alone alone RB cord-015306-us58wwmp 4293 14 transplant transplant NN cord-015306-us58wwmp 4293 15 in in IN cord-015306-us58wwmp 4293 16 the the DT cord-015306-us58wwmp 4293 17 United United NNP cord-015306-us58wwmp 4293 18 Network Network NNP cord-015306-us58wwmp 4293 19 for for IN cord-015306-us58wwmp 4293 20 Organ Organ NNP cord-015306-us58wwmp 4293 21 Sharing Sharing NNP cord-015306-us58wwmp 4293 22 ( ( -LRB- cord-015306-us58wwmp 4293 23 UNOS UNOS NNP cord-015306-us58wwmp 4293 24 ) ) -RRB- cord-015306-us58wwmp 4293 25 dataset dataset NN cord-015306-us58wwmp 4293 26 from from IN cord-015306-us58wwmp 4293 27 January January NNP cord-015306-us58wwmp 4293 28 1 1 CD cord-015306-us58wwmp 4293 29 , , , cord-015306-us58wwmp 4293 30 2008 2008 CD cord-015306-us58wwmp 4293 31 to to IN cord-015306-us58wwmp 4293 32 October October NNP cord-015306-us58wwmp 4293 33 31 31 CD cord-015306-us58wwmp 4293 34 , , , cord-015306-us58wwmp 4293 35 2011 2011 CD cord-015306-us58wwmp 4293 36 . . . cord-015306-us58wwmp 4294 1 Recipients recipient NNS cord-015306-us58wwmp 4294 2 with with IN cord-015306-us58wwmp 4294 3 definite definite JJ cord-015306-us58wwmp 4294 4 , , , cord-015306-us58wwmp 4294 5 probable probable JJ cord-015306-us58wwmp 4294 6 , , , cord-015306-us58wwmp 4294 7 and and CC cord-015306-us58wwmp 4294 8 without without IN cord-015306-us58wwmp 4294 9 ID ID NNP cord-015306-us58wwmp 4294 10 were be VBD cord-015306-us58wwmp 4294 11 compared compare VBN cord-015306-us58wwmp 4294 12 using use VBG cord-015306-us58wwmp 4294 13 chi chi NNP cord-015306-us58wwmp 4294 14 - - HYPH cord-015306-us58wwmp 4294 15 square square NNP cord-015306-us58wwmp 4294 16 and and CC cord-015306-us58wwmp 4294 17 Fisher Fisher NNP cord-015306-us58wwmp 4294 18 's 's POS cord-015306-us58wwmp 4294 19 exact exact JJ cord-015306-us58wwmp 4294 20 tests test NNS cord-015306-us58wwmp 4294 21 . . . cord-015306-us58wwmp 4295 1 Kaplan Kaplan NNP cord-015306-us58wwmp 4295 2 Meier Meier NNP cord-015306-us58wwmp 4295 3 curves curve NNS cord-015306-us58wwmp 4295 4 were be VBD cord-015306-us58wwmp 4295 5 constructed construct VBN cord-015306-us58wwmp 4295 6 for for IN cord-015306-us58wwmp 4295 7 patient patient NN cord-015306-us58wwmp 4295 8 and and CC cord-015306-us58wwmp 4295 9 graft graft NN cord-015306-us58wwmp 4295 10 survival survival NN cord-015306-us58wwmp 4295 11 . . . cord-015306-us58wwmp 4296 1 Results result NNS cord-015306-us58wwmp 4296 2 : : : cord-015306-us58wwmp 4297 1 Over over IN cord-015306-us58wwmp 4297 2 the the DT cord-015306-us58wwmp 4297 3 study study NN cord-015306-us58wwmp 4297 4 period period NN cord-015306-us58wwmp 4297 5 , , , cord-015306-us58wwmp 4297 6 218 218 CD cord-015306-us58wwmp 4297 7 children child NNS cord-015306-us58wwmp 4297 8 with with IN cord-015306-us58wwmp 4297 9 definite definite JJ cord-015306-us58wwmp 4297 10 ( ( -LRB- cord-015306-us58wwmp 4297 11 90 90 CD cord-015306-us58wwmp 4297 12 ) ) -RRB- cord-015306-us58wwmp 4297 13 or or CC cord-015306-us58wwmp 4297 14 probable probable JJ cord-015306-us58wwmp 4297 15 ( ( -LRB- cord-015306-us58wwmp 4297 16 128 128 CD cord-015306-us58wwmp 4297 17 ) ) -RRB- cord-015306-us58wwmp 4297 18 intellectual intellectual JJ cord-015306-us58wwmp 4297 19 disability disability NN cord-015306-us58wwmp 4297 20 underwent undergo VBD cord-015306-us58wwmp 4297 21 first first JJ cord-015306-us58wwmp 4297 22 renal renal JJ cord-015306-us58wwmp 4297 23 transplant transplant NN cord-015306-us58wwmp 4297 24 accounting accounting NN cord-015306-us58wwmp 4297 25 for for IN cord-015306-us58wwmp 4297 26 17 17 CD cord-015306-us58wwmp 4297 27 % % NN cord-015306-us58wwmp 4297 28 of of IN cord-015306-us58wwmp 4297 29 all all DT cord-015306-us58wwmp 4297 30 first first JJ cord-015306-us58wwmp 4297 31 pediatric pediatric JJ cord-015306-us58wwmp 4297 32 renal renal JJ cord-015306-us58wwmp 4297 33 transplants transplant NNS cord-015306-us58wwmp 4297 34 ( ( -LRB- cord-015306-us58wwmp 4297 35 total total JJ cord-015306-us58wwmp 4297 36 n=1280 n=1280 NNP cord-015306-us58wwmp 4297 37 ) ) -RRB- cord-015306-us58wwmp 4297 38 . . . cord-015306-us58wwmp 4298 1 Children child NNS cord-015306-us58wwmp 4298 2 with with IN cord-015306-us58wwmp 4298 3 definite definite JJ cord-015306-us58wwmp 4298 4 or or CC cord-015306-us58wwmp 4298 5 probable probable JJ cord-015306-us58wwmp 4298 6 ID ID NNP cord-015306-us58wwmp 4298 7 did do VBD cord-015306-us58wwmp 4298 8 not not RB cord-015306-us58wwmp 4298 9 significantly significantly RB cord-015306-us58wwmp 4298 10 differ differ VB cord-015306-us58wwmp 4298 11 from from IN cord-015306-us58wwmp 4298 12 other other JJ cord-015306-us58wwmp 4298 13 recipients recipient NNS cord-015306-us58wwmp 4298 14 on on IN cord-015306-us58wwmp 4298 15 the the DT cord-015306-us58wwmp 4298 16 basis basis NN cord-015306-us58wwmp 4298 17 of of IN cord-015306-us58wwmp 4298 18 gender gender NN cord-015306-us58wwmp 4298 19 or or CC cord-015306-us58wwmp 4298 20 ethnicity ethnicity NN cord-015306-us58wwmp 4298 21 but but CC cord-015306-us58wwmp 4298 22 tended tend VBD cord-015306-us58wwmp 4298 23 to to TO cord-015306-us58wwmp 4298 24 be be VB cord-015306-us58wwmp 4298 25 younger young JJR cord-015306-us58wwmp 4298 26 . . . cord-015306-us58wwmp 4299 1 Children child NNS cord-015306-us58wwmp 4299 2 with with IN cord-015306-us58wwmp 4299 3 definite definite JJ cord-015306-us58wwmp 4299 4 ID ID NNP cord-015306-us58wwmp 4299 5 had have VBD cord-015306-us58wwmp 4299 6 higher high JJR cord-015306-us58wwmp 4299 7 rates rate NNS cord-015306-us58wwmp 4299 8 of of IN cord-015306-us58wwmp 4299 9 structural structural JJ cord-015306-us58wwmp 4299 10 kidney kidney NN cord-015306-us58wwmp 4299 11 disease disease NN cord-015306-us58wwmp 4299 12 and and CC cord-015306-us58wwmp 4299 13 lower low JJR cord-015306-us58wwmp 4299 14 rates rate NNS cord-015306-us58wwmp 4299 15 of of IN cord-015306-us58wwmp 4299 16 glomerulonephritis glomerulonephritis NN cord-015306-us58wwmp 4299 17 . . . cord-015306-us58wwmp 4300 1 Children child NNS cord-015306-us58wwmp 4300 2 with with IN cord-015306-us58wwmp 4300 3 ID ID NNP cord-015306-us58wwmp 4300 4 were be VBD cord-015306-us58wwmp 4300 5 not not RB cord-015306-us58wwmp 4300 6 significantly significantly RB cord-015306-us58wwmp 4300 7 different different JJ cord-015306-us58wwmp 4300 8 than than IN cord-015306-us58wwmp 4300 9 children child NNS cord-015306-us58wwmp 4300 10 without without IN cord-015306-us58wwmp 4300 11 ID ID NNP cord-015306-us58wwmp 4300 12 with with IN cord-015306-us58wwmp 4300 13 respect respect NN cord-015306-us58wwmp 4300 14 to to IN cord-015306-us58wwmp 4300 15 rate rate NN cord-015306-us58wwmp 4300 16 of of IN cord-015306-us58wwmp 4300 17 preemptive preemptive JJ cord-015306-us58wwmp 4300 18 transplant transplant NN cord-015306-us58wwmp 4300 19 , , , cord-015306-us58wwmp 4300 20 donor donor NN cord-015306-us58wwmp 4300 21 source source NN cord-015306-us58wwmp 4300 22 , , , cord-015306-us58wwmp 4300 23 or or CC cord-015306-us58wwmp 4300 24 number number NN cord-015306-us58wwmp 4300 25 of of IN cord-015306-us58wwmp 4300 26 episodes episode NNS cord-015306-us58wwmp 4300 27 of of IN cord-015306-us58wwmp 4300 28 acute acute JJ cord-015306-us58wwmp 4300 29 rejection rejection NN cord-015306-us58wwmp 4300 30 . . . cord-015306-us58wwmp 4301 1 Graft graft NN cord-015306-us58wwmp 4301 2 and and CC cord-015306-us58wwmp 4301 3 patient patient JJ cord-015306-us58wwmp 4301 4 survival survival NN cord-015306-us58wwmp 4301 5 were be VBD cord-015306-us58wwmp 4301 6 similar similar JJ cord-015306-us58wwmp 4301 7 between between IN cord-015306-us58wwmp 4301 8 children child NNS cord-015306-us58wwmp 4301 9 with with IN cord-015306-us58wwmp 4301 10 definite definite JJ cord-015306-us58wwmp 4301 11 or or CC cord-015306-us58wwmp 4301 12 probable probable JJ cord-015306-us58wwmp 4301 13 ID id NN cord-015306-us58wwmp 4301 14 and and CC cord-015306-us58wwmp 4301 15 without without IN cord-015306-us58wwmp 4301 16 ID ID NNP cord-015306-us58wwmp 4301 17 . . . cord-015306-us58wwmp 4302 1 In in IN cord-015306-us58wwmp 4302 2 Cox Cox NNP cord-015306-us58wwmp 4302 3 regression regression NN cord-015306-us58wwmp 4302 4 , , , cord-015306-us58wwmp 4302 5 intellectual intellectual JJ cord-015306-us58wwmp 4302 6 disability disability NN cord-015306-us58wwmp 4302 7 was be VBD cord-015306-us58wwmp 4302 8 not not RB cord-015306-us58wwmp 4302 9 significantly significantly RB cord-015306-us58wwmp 4302 10 associated associate VBN cord-015306-us58wwmp 4302 11 with with IN cord-015306-us58wwmp 4302 12 patient patient NN cord-015306-us58wwmp 4302 13 or or CC cord-015306-us58wwmp 4302 14 graft graft NN cord-015306-us58wwmp 4302 15 survival survival NN cord-015306-us58wwmp 4302 16 . . . cord-015306-us58wwmp 4303 1 Conclusion conclusion NN cord-015306-us58wwmp 4303 2 : : : cord-015306-us58wwmp 4304 1 In in IN cord-015306-us58wwmp 4304 2 this this DT cord-015306-us58wwmp 4304 3 first first JJ cord-015306-us58wwmp 4304 4 large large JJ cord-015306-us58wwmp 4304 5 - - HYPH cord-015306-us58wwmp 4304 6 scale scale NN cord-015306-us58wwmp 4304 7 study study NN cord-015306-us58wwmp 4304 8 , , , cord-015306-us58wwmp 4304 9 17 17 CD cord-015306-us58wwmp 4304 10 % % NN cord-015306-us58wwmp 4304 11 of of IN cord-015306-us58wwmp 4304 12 all all DT cord-015306-us58wwmp 4304 13 first first JJ cord-015306-us58wwmp 4304 14 pediatric pediatric JJ cord-015306-us58wwmp 4304 15 renal renal JJ cord-015306-us58wwmp 4304 16 transplants transplant NNS cord-015306-us58wwmp 4304 17 are be VBP cord-015306-us58wwmp 4304 18 performed perform VBN cord-015306-us58wwmp 4304 19 in in IN cord-015306-us58wwmp 4304 20 children child NNS cord-015306-us58wwmp 4304 21 identified identify VBN cord-015306-us58wwmp 4304 22 as as IN cord-015306-us58wwmp 4304 23 having have VBG cord-015306-us58wwmp 4304 24 intellectual intellectual JJ cord-015306-us58wwmp 4304 25 disability disability NN cord-015306-us58wwmp 4304 26 . . . cord-015306-us58wwmp 4305 1 Early early JJ cord-015306-us58wwmp 4305 2 outcomes outcome NNS cord-015306-us58wwmp 4305 3 after after IN cord-015306-us58wwmp 4305 4 transplant transplant NN cord-015306-us58wwmp 4305 5 appear appear VBP cord-015306-us58wwmp 4305 6 to to TO cord-015306-us58wwmp 4305 7 be be VB cord-015306-us58wwmp 4305 8 equivalent equivalent JJ cord-015306-us58wwmp 4305 9 between between IN cord-015306-us58wwmp 4305 10 children child NNS cord-015306-us58wwmp 4305 11 with with IN cord-015306-us58wwmp 4305 12 and and CC cord-015306-us58wwmp 4305 13 without without IN cord-015306-us58wwmp 4305 14 ID ID NNP cord-015306-us58wwmp 4305 15 . . . cord-015306-us58wwmp 4306 1 Further further JJ cord-015306-us58wwmp 4306 2 research research NN cord-015306-us58wwmp 4306 3 is be VBZ cord-015306-us58wwmp 4306 4 needed need VBN cord-015306-us58wwmp 4306 5 on on IN cord-015306-us58wwmp 4306 6 long long JJ cord-015306-us58wwmp 4306 7 - - HYPH cord-015306-us58wwmp 4306 8 term term NN cord-015306-us58wwmp 4306 9 outcomes outcome NNS cord-015306-us58wwmp 4306 10 and and CC cord-015306-us58wwmp 4306 11 quality quality NN cord-015306-us58wwmp 4306 12 of of IN cord-015306-us58wwmp 4306 13 life life NN cord-015306-us58wwmp 4306 14 effects effect NNS cord-015306-us58wwmp 4306 15 of of IN cord-015306-us58wwmp 4306 16 transplant transplant NN cord-015306-us58wwmp 4306 17 in in IN cord-015306-us58wwmp 4306 18 this this DT cord-015306-us58wwmp 4306 19 population population NN cord-015306-us58wwmp 4306 20 . . . cord-015306-us58wwmp 4307 1 Mariana Mariana NNP cord-015306-us58wwmp 4307 2 Guerra Guerra NNP cord-015306-us58wwmp 4307 3 Duarte Duarte NNP cord-015306-us58wwmp 4307 4 Rosa Rosa NNP cord-015306-us58wwmp 4307 5 de de NNP cord-015306-us58wwmp 4307 6 Lima Lima NNP cord-015306-us58wwmp 4307 7 , , , cord-015306-us58wwmp 4307 8 Ana Ana NNP cord-015306-us58wwmp 4307 9 Cristina Cristina NNP cord-015306-us58wwmp 4307 10 Simoes Simoes NNP cord-015306-us58wwmp 4307 11 e e NNP cord-015306-us58wwmp 4307 12 Silva Silva NNP cord-015306-us58wwmp 4307 13 , , , cord-015306-us58wwmp 4307 14 Nadine Nadine NNP cord-015306-us58wwmp 4307 15 Marcia Marcia NNP cord-015306-us58wwmp 4307 16 de de NNP cord-015306-us58wwmp 4307 17 Faria Faria NNP cord-015306-us58wwmp 4307 18 , , , cord-015306-us58wwmp 4307 19 Eleonora Eleonora NNP cord-015306-us58wwmp 4307 20 Moreira Moreira NNP cord-015306-us58wwmp 4307 21 Lima Lima NNP cord-015306-us58wwmp 4307 22 Pediatrics Pediatrics NNP cord-015306-us58wwmp 4307 23 , , , cord-015306-us58wwmp 4307 24 Universidade Universidade NNP cord-015306-us58wwmp 4307 25 Federal Federal NNP cord-015306-us58wwmp 4307 26 de de NNP cord-015306-us58wwmp 4307 27 Minas Minas NNP cord-015306-us58wwmp 4307 28 Gerais Gerais NNP cord-015306-us58wwmp 4307 29 , , , cord-015306-us58wwmp 4307 30 Belo Belo NNP cord-015306-us58wwmp 4307 31 Horizonte Horizonte NNP cord-015306-us58wwmp 4307 32 , , , cord-015306-us58wwmp 4307 33 BrazilObjective BrazilObjective NNP cord-015306-us58wwmp 4307 34 : : : cord-015306-us58wwmp 4308 1 The the DT cord-015306-us58wwmp 4308 2 aim aim NN cord-015306-us58wwmp 4308 3 of of IN cord-015306-us58wwmp 4308 4 this this DT cord-015306-us58wwmp 4308 5 study study NN cord-015306-us58wwmp 4308 6 was be VBD cord-015306-us58wwmp 4308 7 to to TO cord-015306-us58wwmp 4308 8 evaluate evaluate VB cord-015306-us58wwmp 4308 9 the the DT cord-015306-us58wwmp 4308 10 clinical clinical JJ cord-015306-us58wwmp 4308 11 course course NN cord-015306-us58wwmp 4308 12 of of IN cord-015306-us58wwmp 4308 13 children child NNS cord-015306-us58wwmp 4308 14 and and CC cord-015306-us58wwmp 4308 15 adolescents adolescent NNS cord-015306-us58wwmp 4308 16 undergoing undergo VBG cord-015306-us58wwmp 4308 17 renal renal JJ cord-015306-us58wwmp 4308 18 transplantation transplantation NN cord-015306-us58wwmp 4308 19 at at IN cord-015306-us58wwmp 4308 20 Federal Federal NNP cord-015306-us58wwmp 4308 21 University University NNP cord-015306-us58wwmp 4308 22 of of IN cord-015306-us58wwmp 4308 23 Minas Minas NNP cord-015306-us58wwmp 4308 24 Gerais Gerais NNP cord-015306-us58wwmp 4308 25 between between IN cord-015306-us58wwmp 4308 26 2000 2000 CD cord-015306-us58wwmp 4308 27 and and CC cord-015306-us58wwmp 4308 28 2011 2011 CD cord-015306-us58wwmp 4308 29 and and CC cord-015306-us58wwmp 4308 30 to to TO cord-015306-us58wwmp 4308 31 identify identify VB cord-015306-us58wwmp 4308 32 possible possible JJ cord-015306-us58wwmp 4308 33 factors factor NNS cord-015306-us58wwmp 4308 34 that that WDT cord-015306-us58wwmp 4308 35 could could MD cord-015306-us58wwmp 4308 36 interfere interfere VB cord-015306-us58wwmp 4308 37 with with IN cord-015306-us58wwmp 4308 38 graft graft NN cord-015306-us58wwmp 4308 39 survival survival NN cord-015306-us58wwmp 4308 40 . . . cord-015306-us58wwmp 4309 1 Methods method NNS cord-015306-us58wwmp 4309 2 : : : cord-015306-us58wwmp 4310 1 A a DT cord-015306-us58wwmp 4310 2 retrospective retrospective JJ cord-015306-us58wwmp 4310 3 observational observational JJ cord-015306-us58wwmp 4310 4 cohort cohort NN cord-015306-us58wwmp 4310 5 study study NN cord-015306-us58wwmp 4310 6 through through IN cord-015306-us58wwmp 4310 7 analysis analysis NN cord-015306-us58wwmp 4310 8 of of IN cord-015306-us58wwmp 4310 9 medical medical JJ cord-015306-us58wwmp 4310 10 records record NNS cord-015306-us58wwmp 4310 11 of of IN cord-015306-us58wwmp 4310 12 patients patient NNS cord-015306-us58wwmp 4310 13 below below IN cord-015306-us58wwmp 4310 14 18 18 CD cord-015306-us58wwmp 4310 15 years year NNS cord-015306-us58wwmp 4310 16 submitted submit VBN cord-015306-us58wwmp 4310 17 to to IN cord-015306-us58wwmp 4310 18 renal renal JJ cord-015306-us58wwmp 4310 19 transplant transplant NN cord-015306-us58wwmp 4310 20 were be VBD cord-015306-us58wwmp 4310 21 performed perform VBN cord-015306-us58wwmp 4310 22 . . . cord-015306-us58wwmp 4311 1 Data datum NNS cord-015306-us58wwmp 4311 2 were be VBD cord-015306-us58wwmp 4311 3 analyzed analyze VBN cord-015306-us58wwmp 4311 4 in in IN cord-015306-us58wwmp 4311 5 SPSS SPSS NNP cord-015306-us58wwmp 4311 6 , , , cord-015306-us58wwmp 4311 7 version version NN cord-015306-us58wwmp 4311 8 19.0 19.0 CD cord-015306-us58wwmp 4311 9 . . . cord-015306-us58wwmp 4312 1 The the DT cord-015306-us58wwmp 4312 2 results result NNS cord-015306-us58wwmp 4312 3 were be VBD cord-015306-us58wwmp 4312 4 expressed express VBN cord-015306-us58wwmp 4312 5 by by IN cord-015306-us58wwmp 4312 6 descriptive descriptive JJ cord-015306-us58wwmp 4312 7 variables variable NNS cord-015306-us58wwmp 4312 8 and and CC cord-015306-us58wwmp 4312 9 survival survival NN cord-015306-us58wwmp 4312 10 analysis analysis NN cord-015306-us58wwmp 4312 11 was be VBD cord-015306-us58wwmp 4312 12 performed perform VBN cord-015306-us58wwmp 4312 13 using use VBG cord-015306-us58wwmp 4312 14 the the DT cord-015306-us58wwmp 4312 15 Kaplan Kaplan NNP cord-015306-us58wwmp 4312 16 - - HYPH cord-015306-us58wwmp 4312 17 Meier Meier NNP cord-015306-us58wwmp 4312 18 method method NN cord-015306-us58wwmp 4312 19 . . . cord-015306-us58wwmp 4313 1 Comparisons comparison NNS cord-015306-us58wwmp 4313 2 between between IN cord-015306-us58wwmp 4313 3 subgroups subgroup NNS cord-015306-us58wwmp 4313 4 were be VBD cord-015306-us58wwmp 4313 5 made make VBN cord-015306-us58wwmp 4313 6 using use VBG cord-015306-us58wwmp 4313 7 the the DT cord-015306-us58wwmp 4313 8 log log NN cord-015306-us58wwmp 4313 9 - - HYPH cord-015306-us58wwmp 4313 10 rank rank NN cord-015306-us58wwmp 4313 11 test test NN cord-015306-us58wwmp 4313 12 . . . cord-015306-us58wwmp 4314 1 P p NN cord-015306-us58wwmp 4314 2 level level NN cord-015306-us58wwmp 4314 3 was be VBD cord-015306-us58wwmp 4314 4 set set VBN cord-015306-us58wwmp 4314 5 at at IN cord-015306-us58wwmp 4314 6 below below IN cord-015306-us58wwmp 4314 7 5 5 CD cord-015306-us58wwmp 4314 8 % % NN cord-015306-us58wwmp 4314 9 . . . cord-015306-us58wwmp 4315 1 Results result NNS cord-015306-us58wwmp 4315 2 : : : cord-015306-us58wwmp 4316 1 We -PRON- PRP cord-015306-us58wwmp 4316 2 analyzed analyze VBD cord-015306-us58wwmp 4316 3 64 64 CD cord-015306-us58wwmp 4316 4 patients patient NNS cord-015306-us58wwmp 4316 5 who who WP cord-015306-us58wwmp 4316 6 underwent undergo VBD cord-015306-us58wwmp 4316 7 66 66 CD cord-015306-us58wwmp 4316 8 transplants transplant NNS cord-015306-us58wwmp 4316 9 . . . cord-015306-us58wwmp 4317 1 The the DT cord-015306-us58wwmp 4317 2 mean mean JJ cord-015306-us58wwmp 4317 3 age age NN cord-015306-us58wwmp 4317 4 was be VBD cord-015306-us58wwmp 4317 5 10.5 10.5 CD cord-015306-us58wwmp 4317 6 ± ± NNP cord-015306-us58wwmp 4317 7 3.9 3.9 CD cord-015306-us58wwmp 4317 8 years year NNS cord-015306-us58wwmp 4317 9 . . . cord-015306-us58wwmp 4318 1 The the DT cord-015306-us58wwmp 4318 2 main main JJ cord-015306-us58wwmp 4318 3 causes cause NNS cord-015306-us58wwmp 4318 4 of of IN cord-015306-us58wwmp 4318 5 chronic chronic JJ cord-015306-us58wwmp 4318 6 kidney kidney NN cord-015306-us58wwmp 4318 7 disease disease NN cord-015306-us58wwmp 4318 8 were be VBD cord-015306-us58wwmp 4318 9 CAKUT CAKUT NNP cord-015306-us58wwmp 4318 10 ( ( -LRB- cord-015306-us58wwmp 4318 11 32.8 32.8 CD cord-015306-us58wwmp 4318 12 % % NN cord-015306-us58wwmp 4318 13 ) ) -RRB- cord-015306-us58wwmp 4318 14 and and CC cord-015306-us58wwmp 4318 15 glomerular glomerular JJ cord-015306-us58wwmp 4318 16 diseases disease NNS cord-015306-us58wwmp 4318 17 ( ( -LRB- cord-015306-us58wwmp 4318 18 26.6 26.6 CD cord-015306-us58wwmp 4318 19 % % NN cord-015306-us58wwmp 4318 20 ) ) -RRB- cord-015306-us58wwmp 4318 21 . . . cord-015306-us58wwmp 4319 1 Most Most JJS cord-015306-us58wwmp 4319 2 patients patient NNS cord-015306-us58wwmp 4319 3 were be VBD cord-015306-us58wwmp 4319 4 submitted submit VBN cord-015306-us58wwmp 4319 5 to to IN cord-015306-us58wwmp 4319 6 dialysis dialysis NN cord-015306-us58wwmp 4319 7 before before IN cord-015306-us58wwmp 4319 8 transplantation transplantation NN cord-015306-us58wwmp 4319 9 ( ( -LRB- cord-015306-us58wwmp 4319 10 81.9 81.9 CD cord-015306-us58wwmp 4319 11 % % NN cord-015306-us58wwmp 4319 12 ) ) -RRB- cord-015306-us58wwmp 4319 13 with with IN cord-015306-us58wwmp 4319 14 a a DT cord-015306-us58wwmp 4319 15 mean mean JJ cord-015306-us58wwmp 4319 16 duration duration NN cord-015306-us58wwmp 4319 17 of of IN cord-015306-us58wwmp 4319 18 36.5 36.5 CD cord-015306-us58wwmp 4319 19 ± ± CD cord-015306-us58wwmp 4319 20 25.5 25.5 CD cord-015306-us58wwmp 4319 21 months month NNS cord-015306-us58wwmp 4319 22 . . . cord-015306-us58wwmp 4320 1 Deceased deceased JJ cord-015306-us58wwmp 4320 2 donor donor NN cord-015306-us58wwmp 4320 3 was be VBD cord-015306-us58wwmp 4320 4 used use VBN cord-015306-us58wwmp 4320 5 in in IN cord-015306-us58wwmp 4320 6 57.6 57.6 CD cord-015306-us58wwmp 4320 7 % % NN cord-015306-us58wwmp 4320 8 and and CC cord-015306-us58wwmp 4320 9 the the DT cord-015306-us58wwmp 4320 10 average average JJ cord-015306-us58wwmp 4320 11 cold cold JJ cord-015306-us58wwmp 4320 12 ischemia ischemia NN cord-015306-us58wwmp 4320 13 time time NN cord-015306-us58wwmp 4320 14 was be VBD cord-015306-us58wwmp 4320 15 22.2 22.2 CD cord-015306-us58wwmp 4320 16 ± ± CD cord-015306-us58wwmp 4320 17 6.3 6.3 CD cord-015306-us58wwmp 4320 18 hours hour NNS cord-015306-us58wwmp 4320 19 . . . cord-015306-us58wwmp 4321 1 Dialysis dialysis NN cord-015306-us58wwmp 4321 2 after after IN cord-015306-us58wwmp 4321 3 renal renal JJ cord-015306-us58wwmp 4321 4 transplantation transplantation NN cord-015306-us58wwmp 4321 5 was be VBD cord-015306-us58wwmp 4321 6 performed perform VBN cord-015306-us58wwmp 4321 7 in in IN cord-015306-us58wwmp 4321 8 22.7 22.7 CD cord-015306-us58wwmp 4321 9 % % NN cord-015306-us58wwmp 4321 10 of of IN cord-015306-us58wwmp 4321 11 cases case NNS cord-015306-us58wwmp 4321 12 . . . cord-015306-us58wwmp 4322 1 The the DT cord-015306-us58wwmp 4322 2 median median JJ cord-015306-us58wwmp 4322 3 survival survival NN cord-015306-us58wwmp 4322 4 of of IN cord-015306-us58wwmp 4322 5 patients patient NNS cord-015306-us58wwmp 4322 6 1 1 CD cord-015306-us58wwmp 4322 7 , , , cord-015306-us58wwmp 4322 8 5 5 CD cord-015306-us58wwmp 4322 9 and and CC cord-015306-us58wwmp 4322 10 10 10 CD cord-015306-us58wwmp 4322 11 years year NNS cord-015306-us58wwmp 4322 12 was be VBD cord-015306-us58wwmp 4322 13 98.3 98.3 CD cord-015306-us58wwmp 4322 14 % % NN cord-015306-us58wwmp 4322 15 , , , cord-015306-us58wwmp 4322 16 95.8 95.8 CD cord-015306-us58wwmp 4322 17 % % NN cord-015306-us58wwmp 4322 18 and and CC cord-015306-us58wwmp 4322 19 92.8 92.8 CD cord-015306-us58wwmp 4322 20 % % NN cord-015306-us58wwmp 4322 21 . . . cord-015306-us58wwmp 4323 1 There there EX cord-015306-us58wwmp 4323 2 were be VBD cord-015306-us58wwmp 4323 3 four four CD cord-015306-us58wwmp 4323 4 deaths death NNS cord-015306-us58wwmp 4323 5 in in IN cord-015306-us58wwmp 4323 6 this this DT cord-015306-us58wwmp 4323 7 population population NN cord-015306-us58wwmp 4323 8 , , , cord-015306-us58wwmp 4323 9 two two CD cord-015306-us58wwmp 4323 10 after after IN cord-015306-us58wwmp 4323 11 graft graft NN cord-015306-us58wwmp 4323 12 loss loss NN cord-015306-us58wwmp 4323 13 . . . cord-015306-us58wwmp 4324 1 Twelve twelve CD cord-015306-us58wwmp 4324 2 patients patient NNS cord-015306-us58wwmp 4324 3 lost lose VBD cord-015306-us58wwmp 4324 4 their -PRON- PRP$ cord-015306-us58wwmp 4324 5 grafts graft NNS cord-015306-us58wwmp 4324 6 ( ( -LRB- cord-015306-us58wwmp 4324 7 19.7 19.7 CD cord-015306-us58wwmp 4324 8 % % NN cord-015306-us58wwmp 4324 9 ) ) -RRB- cord-015306-us58wwmp 4324 10 . . . cord-015306-us58wwmp 4325 1 The the DT cord-015306-us58wwmp 4325 2 median median JJ cord-015306-us58wwmp 4325 3 survival survival NN cord-015306-us58wwmp 4325 4 of of IN cord-015306-us58wwmp 4325 5 the the DT cord-015306-us58wwmp 4325 6 graft graft NN cord-015306-us58wwmp 4325 7 was be VBD cord-015306-us58wwmp 4325 8 9.2 9.2 CD cord-015306-us58wwmp 4325 9 years year NNS cord-015306-us58wwmp 4325 10 and and CC cord-015306-us58wwmp 4326 1 1 1 CD cord-015306-us58wwmp 4326 2 , , , cord-015306-us58wwmp 4326 3 5 5 CD cord-015306-us58wwmp 4326 4 and and CC cord-015306-us58wwmp 4326 5 10 10 CD cord-015306-us58wwmp 4326 6 years year NNS cord-015306-us58wwmp 4326 7 survival survival NN cord-015306-us58wwmp 4326 8 was be VBD cord-015306-us58wwmp 4326 9 91.7 91.7 CD cord-015306-us58wwmp 4326 10 % % NN cord-015306-us58wwmp 4326 11 , , , cord-015306-us58wwmp 4326 12 81.2 81.2 CD cord-015306-us58wwmp 4326 13 % % NN cord-015306-us58wwmp 4326 14 and and CC cord-015306-us58wwmp 4326 15 75.6 75.6 CD cord-015306-us58wwmp 4326 16 % % NN cord-015306-us58wwmp 4326 17 , , , cord-015306-us58wwmp 4326 18 respectively respectively RB cord-015306-us58wwmp 4326 19 . . . cord-015306-us58wwmp 4327 1 No no DT cord-015306-us58wwmp 4327 2 statistical statistical JJ cord-015306-us58wwmp 4327 3 difference difference NN cord-015306-us58wwmp 4327 4 was be VBD cord-015306-us58wwmp 4327 5 detected detect VBN cord-015306-us58wwmp 4327 6 in in IN cord-015306-us58wwmp 4327 7 graft graft NN cord-015306-us58wwmp 4327 8 survival survival NN cord-015306-us58wwmp 4327 9 between between IN cord-015306-us58wwmp 4327 10 the the DT cord-015306-us58wwmp 4327 11 deceased deceased JJ cord-015306-us58wwmp 4327 12 versus versus IN cord-015306-us58wwmp 4327 13 . . . cord-015306-us58wwmp 4328 1 living live VBG cord-015306-us58wwmp 4328 2 donor donor NN cord-015306-us58wwmp 4328 3 recipients recipient NNS cord-015306-us58wwmp 4328 4 , , , cord-015306-us58wwmp 4328 5 the the DT cord-015306-us58wwmp 4328 6 different different JJ cord-015306-us58wwmp 4328 7 age age NN cord-015306-us58wwmp 4328 8 groups group NNS cord-015306-us58wwmp 4328 9 , , , cord-015306-us58wwmp 4328 10 the the DT cord-015306-us58wwmp 4328 11 occurrence occurrence NN cord-015306-us58wwmp 4328 12 of of IN cord-015306-us58wwmp 4328 13 hypertension hypertension NN cord-015306-us58wwmp 4328 14 or or CC cord-015306-us58wwmp 4328 15 not not RB cord-015306-us58wwmp 4328 16 , , , cord-015306-us58wwmp 4328 17 the the DT cord-015306-us58wwmp 4328 18 preemptive preemptive JJ cord-015306-us58wwmp 4328 19 transplantation transplantation NN cord-015306-us58wwmp 4328 20 vs. vs. IN cord-015306-us58wwmp 4328 21 preceded precede VBN cord-015306-us58wwmp 4328 22 by by IN cord-015306-us58wwmp 4328 23 dialysis dialysis NN cord-015306-us58wwmp 4328 24 ( ( -LRB- cord-015306-us58wwmp 4328 25 p=0.97 p=0.97 NNP cord-015306-us58wwmp 4328 26 ) ) -RRB- cord-015306-us58wwmp 4328 27 and and CC cord-015306-us58wwmp 4328 28 those those DT cord-015306-us58wwmp 4328 29 with with IN cord-015306-us58wwmp 4328 30 more more JJR cord-015306-us58wwmp 4328 31 than than IN cord-015306-us58wwmp 4328 32 three three CD cord-015306-us58wwmp 4328 33 versus versus IN cord-015306-us58wwmp 4328 34 less less JJR cord-015306-us58wwmp 4328 35 than than IN cord-015306-us58wwmp 4328 36 three three CD cord-015306-us58wwmp 4328 37 HLA HLA NNP cord-015306-us58wwmp 4328 38 mismatches mismatch NNS cord-015306-us58wwmp 4328 39 . . . cord-015306-us58wwmp 4329 1 A a DT cord-015306-us58wwmp 4329 2 significant significant JJ cord-015306-us58wwmp 4329 3 reduction reduction NN cord-015306-us58wwmp 4329 4 in in IN cord-015306-us58wwmp 4329 5 graft graft NN cord-015306-us58wwmp 4329 6 survival survival NN cord-015306-us58wwmp 4329 7 was be VBD cord-015306-us58wwmp 4329 8 associated associate VBN cord-015306-us58wwmp 4329 9 with with IN cord-015306-us58wwmp 4329 10 cold cold JJ cord-015306-us58wwmp 4329 11 ischemia ischemia NN cord-015306-us58wwmp 4329 12 time time NN cord-015306-us58wwmp 4329 13 associated associate VBN cord-015306-us58wwmp 4329 14 with with IN cord-015306-us58wwmp 4329 15 24h 24h NNS cord-015306-us58wwmp 4329 16 , , , cord-015306-us58wwmp 4329 17 need need VBP cord-015306-us58wwmp 4329 18 for for IN cord-015306-us58wwmp 4329 19 dialysis dialysis NN cord-015306-us58wwmp 4329 20 after after IN cord-015306-us58wwmp 4329 21 transplantation transplantation NN cord-015306-us58wwmp 4329 22 , , , cord-015306-us58wwmp 4329 23 early early JJ cord-015306-us58wwmp 4329 24 acute acute JJ cord-015306-us58wwmp 4329 25 or or CC cord-015306-us58wwmp 4329 26 late late JJ cord-015306-us58wwmp 4329 27 rejection rejection NN cord-015306-us58wwmp 4329 28 and and CC cord-015306-us58wwmp 4330 1 creatinine creatinine NN cord-015306-us58wwmp 4330 2 greater great JJR cord-015306-us58wwmp 4330 3 than than IN cord-015306-us58wwmp 4330 4 1 1 CD cord-015306-us58wwmp 4330 5 mg mg NN cord-015306-us58wwmp 4330 6 per per IN cord-015306-us58wwmp 4330 7 dl dl NN cord-015306-us58wwmp 4330 8 after after IN cord-015306-us58wwmp 4330 9 the the DT cord-015306-us58wwmp 4330 10 first first JJ cord-015306-us58wwmp 4330 11 year year NN cord-015306-us58wwmp 4330 12 os os NN cord-015306-us58wwmp 4330 13 transplantation transplantation NN cord-015306-us58wwmp 4330 14 . . . cord-015306-us58wwmp 4331 1 Conclusion conclusion NN cord-015306-us58wwmp 4331 2 : : : cord-015306-us58wwmp 4332 1 In in IN cord-015306-us58wwmp 4332 2 our -PRON- PRP$ cord-015306-us58wwmp 4332 3 center center NN cord-015306-us58wwmp 4332 4 , , , cord-015306-us58wwmp 4332 5 graft graft NN cord-015306-us58wwmp 4332 6 survival survival NN cord-015306-us58wwmp 4332 7 was be VBD cord-015306-us58wwmp 4332 8 similar similar JJ cord-015306-us58wwmp 4332 9 to to IN cord-015306-us58wwmp 4332 10 that that DT cord-015306-us58wwmp 4332 11 described describe VBN cord-015306-us58wwmp 4332 12 in in IN cord-015306-us58wwmp 4332 13 the the DT cord-015306-us58wwmp 4332 14 literature literature NN cord-015306-us58wwmp 4332 15 . . . cord-015306-us58wwmp 4333 1 However however RB cord-015306-us58wwmp 4333 2 , , , cord-015306-us58wwmp 4333 3 further further JJ cord-015306-us58wwmp 4333 4 studies study NNS cord-015306-us58wwmp 4333 5 are be VBP cord-015306-us58wwmp 4333 6 needed need VBN cord-015306-us58wwmp 4333 7 to to TO cord-015306-us58wwmp 4333 8 address address VB cord-015306-us58wwmp 4333 9 the the DT cord-015306-us58wwmp 4333 10 variables variable NNS cord-015306-us58wwmp 4333 11 that that WDT cord-015306-us58wwmp 4333 12 negatively negatively RB cord-015306-us58wwmp 4333 13 impacted impact VBD cord-015306-us58wwmp 4333 14 the the DT cord-015306-us58wwmp 4333 15 results result NNS cord-015306-us58wwmp 4333 16 of of IN cord-015306-us58wwmp 4333 17 transplantation transplantation NN cord-015306-us58wwmp 4333 18 . . . cord-015306-us58wwmp 4334 1 Objective objective NN cord-015306-us58wwmp 4334 2 : : : cord-015306-us58wwmp 4335 1 The the DT cord-015306-us58wwmp 4335 2 aim aim NN cord-015306-us58wwmp 4335 3 of of IN cord-015306-us58wwmp 4335 4 this this DT cord-015306-us58wwmp 4335 5 study study NN cord-015306-us58wwmp 4335 6 is be VBZ cord-015306-us58wwmp 4335 7 to to TO cord-015306-us58wwmp 4335 8 assess assess VB cord-015306-us58wwmp 4335 9 whether whether IN cord-015306-us58wwmp 4335 10 there there EX cord-015306-us58wwmp 4335 11 is be VBZ cord-015306-us58wwmp 4335 12 an an DT cord-015306-us58wwmp 4335 13 increase increase NN cord-015306-us58wwmp 4335 14 in in IN cord-015306-us58wwmp 4335 15 anti anti JJ cord-015306-us58wwmp 4335 16 - - JJ cord-015306-us58wwmp 4335 17 HLA HLA NNP cord-015306-us58wwmp 4335 18 antibodies antibody NNS cord-015306-us58wwmp 4335 19 after after IN cord-015306-us58wwmp 4335 20 the the DT cord-015306-us58wwmp 4335 21 Influenza Influenza NNP cord-015306-us58wwmp 4335 22 A A NNP cord-015306-us58wwmp 4335 23 / / SYM cord-015306-us58wwmp 4335 24 H1N1 H1N1 NNP cord-015306-us58wwmp 4335 25 vaccine vaccine NN cord-015306-us58wwmp 4335 26 given give VBN cord-015306-us58wwmp 4335 27 to to IN cord-015306-us58wwmp 4335 28 pediatric pediatric JJ cord-015306-us58wwmp 4335 29 pts pt NNS cord-015306-us58wwmp 4335 30 with with IN cord-015306-us58wwmp 4335 31 ESRD ESRD NNP cord-015306-us58wwmp 4335 32 on on IN cord-015306-us58wwmp 4335 33 dialysis dialysis NN cord-015306-us58wwmp 4335 34 ( ( -LRB- cord-015306-us58wwmp 4335 35 D D NNP cord-015306-us58wwmp 4335 36 ) ) -RRB- cord-015306-us58wwmp 4335 37 and and CC cord-015306-us58wwmp 4335 38 with with IN cord-015306-us58wwmp 4335 39 kidney kidney NN cord-015306-us58wwmp 4335 40 transplant transplant NN cord-015306-us58wwmp 4335 41 ( ( -LRB- cord-015306-us58wwmp 4335 42 T T NNP cord-015306-us58wwmp 4335 43 ) ) -RRB- cord-015306-us58wwmp 4335 44 . . . cord-015306-us58wwmp 4336 1 Methods method NNS cord-015306-us58wwmp 4336 2 : : : cord-015306-us58wwmp 4336 3 21 21 CD cord-015306-us58wwmp 4336 4 pediatric pediatric JJ cord-015306-us58wwmp 4336 5 pts pt NNS cord-015306-us58wwmp 4336 6 were be VBD cord-015306-us58wwmp 4336 7 enrolled enrol VBN cord-015306-us58wwmp 4336 8 . . . cord-015306-us58wwmp 4337 1 Mean mean JJ cord-015306-us58wwmp 4337 2 age age NN cord-015306-us58wwmp 4337 3 was be VBD cord-015306-us58wwmp 4337 4 15.5 15.5 CD cord-015306-us58wwmp 4337 5 years year NNS cord-015306-us58wwmp 4337 6 old old JJ cord-015306-us58wwmp 4337 7 , , , cord-015306-us58wwmp 4337 8 29 29 CD cord-015306-us58wwmp 4337 9 % % NN cord-015306-us58wwmp 4337 10 female female NN cord-015306-us58wwmp 4337 11 , , , cord-015306-us58wwmp 4337 12 71 71 CD cord-015306-us58wwmp 4337 13 % % NN cord-015306-us58wwmp 4337 14 male male NN cord-015306-us58wwmp 4337 15 , , , cord-015306-us58wwmp 4337 16 57 57 CD cord-015306-us58wwmp 4337 17 % % NN cord-015306-us58wwmp 4337 18 African african JJ cord-015306-us58wwmp 4337 19 American American NNP cord-015306-us58wwmp 4337 20 , , , cord-015306-us58wwmp 4337 21 29 29 CD cord-015306-us58wwmp 4337 22 % % NN cord-015306-us58wwmp 4337 23 Hispanic hispanic JJ cord-015306-us58wwmp 4337 24 . . . cord-015306-us58wwmp 4338 1 Objective objective NN cord-015306-us58wwmp 4338 2 : : : cord-015306-us58wwmp 4339 1 PTLD PTLD NNP cord-015306-us58wwmp 4339 2 is be VBZ cord-015306-us58wwmp 4339 3 the the DT cord-015306-us58wwmp 4339 4 most most RBS cord-015306-us58wwmp 4339 5 common common JJ cord-015306-us58wwmp 4339 6 malignancy malignancy NN cord-015306-us58wwmp 4339 7 and and CC cord-015306-us58wwmp 4339 8 important important JJ cord-015306-us58wwmp 4339 9 complication complication NN cord-015306-us58wwmp 4339 10 of of IN cord-015306-us58wwmp 4339 11 pediatric pediatric JJ cord-015306-us58wwmp 4339 12 solid solid JJ cord-015306-us58wwmp 4339 13 organ organ NN cord-015306-us58wwmp 4339 14 transplantation transplantation NN cord-015306-us58wwmp 4339 15 . . . cord-015306-us58wwmp 4340 1 The the DT cord-015306-us58wwmp 4340 2 rates rate NNS cord-015306-us58wwmp 4340 3 of of IN cord-015306-us58wwmp 4340 4 PLTD PLTD NNP cord-015306-us58wwmp 4340 5 have have VBP cord-015306-us58wwmp 4340 6 been be VBN cord-015306-us58wwmp 4340 7 increasing increase VBG cord-015306-us58wwmp 4340 8 through through IN cord-015306-us58wwmp 4340 9 1990s 1990 NNS cord-015306-us58wwmp 4340 10 in in IN cord-015306-us58wwmp 4340 11 KTx KTx NNS cord-015306-us58wwmp 4340 12 recipients recipient NNS cord-015306-us58wwmp 4340 13 . . . cord-015306-us58wwmp 4341 1 We -PRON- PRP cord-015306-us58wwmp 4341 2 conducted conduct VBD cord-015306-us58wwmp 4341 3 a a DT cord-015306-us58wwmp 4341 4 survey survey NN cord-015306-us58wwmp 4341 5 of of IN cord-015306-us58wwmp 4341 6 PTLD PTLD NNP cord-015306-us58wwmp 4341 7 in in IN cord-015306-us58wwmp 4341 8 children child NNS cord-015306-us58wwmp 4341 9 who who WP cord-015306-us58wwmp 4341 10 received receive VBD cord-015306-us58wwmp 4341 11 KTx KTx NNS cord-015306-us58wwmp 4341 12 since since IN cord-015306-us58wwmp 4341 13 the the DT cord-015306-us58wwmp 4341 14 introduction introduction NN cord-015306-us58wwmp 4341 15 of of IN cord-015306-us58wwmp 4341 16 Tac Tac NNP cord-015306-us58wwmp 4341 17 . . . cord-015306-us58wwmp 4342 1 Methods method NNS cord-015306-us58wwmp 4342 2 : : : cord-015306-us58wwmp 4343 1 From from IN cord-015306-us58wwmp 4343 2 1975 1975 CD cord-015306-us58wwmp 4343 3 , , , cord-015306-us58wwmp 4343 4 KTx KTx NNS cord-015306-us58wwmp 4343 5 was be VBD cord-015306-us58wwmp 4343 6 performed perform VBN cord-015306-us58wwmp 4343 7 in in IN cord-015306-us58wwmp 4343 8 463 463 CD cord-015306-us58wwmp 4343 9 recipients recipient NNS cord-015306-us58wwmp 4343 10 at at IN cord-015306-us58wwmp 4343 11 our -PRON- PRP$ cord-015306-us58wwmp 4343 12 center center NN cord-015306-us58wwmp 4343 13 . . . cord-015306-us58wwmp 4344 1 Among among IN cord-015306-us58wwmp 4344 2 them -PRON- PRP cord-015306-us58wwmp 4344 3 , , , cord-015306-us58wwmp 4344 4 we -PRON- PRP cord-015306-us58wwmp 4344 5 analyzed analyze VBD cord-015306-us58wwmp 4344 6 data datum NNS cord-015306-us58wwmp 4344 7 from from IN cord-015306-us58wwmp 4344 8 children child NNS cord-015306-us58wwmp 4344 9 who who WP cord-015306-us58wwmp 4344 10 had have VBD cord-015306-us58wwmp 4344 11 undergone undergo VBN cord-015306-us58wwmp 4344 12 KTx KTx NNS cord-015306-us58wwmp 4344 13 since since IN cord-015306-us58wwmp 4344 14 the the DT cord-015306-us58wwmp 4344 15 introduction introduction NN cord-015306-us58wwmp 4344 16 of of IN cord-015306-us58wwmp 4344 17 Tac Tac NNP cord-015306-us58wwmp 4344 18 and and CC cord-015306-us58wwmp 4344 19 retrospectively retrospectively RB cord-015306-us58wwmp 4344 20 studied study VBD cord-015306-us58wwmp 4344 21 incidence incidence NN cord-015306-us58wwmp 4344 22 of of IN cord-015306-us58wwmp 4344 23 PTLD PTLD NNP cord-015306-us58wwmp 4344 24 and and CC cord-015306-us58wwmp 4344 25 risk risk NN cord-015306-us58wwmp 4344 26 factors factor NNS cord-015306-us58wwmp 4344 27 , , , cord-015306-us58wwmp 4344 28 including include VBG cord-015306-us58wwmp 4344 29 immunosuppression immunosuppression NN cord-015306-us58wwmp 4344 30 protocol protocol NN cord-015306-us58wwmp 4344 31 and and CC cord-015306-us58wwmp 4344 32 pre pre NNS cord-015306-us58wwmp 4344 33 - - JJ cord-015306-us58wwmp 4344 34 KTx ktx JJ cord-015306-us58wwmp 4344 35 EBV EBV NNP cord-015306-us58wwmp 4344 36 serology serology NN cord-015306-us58wwmp 4344 37 . . . cord-015306-us58wwmp 4345 1 Results result NNS cord-015306-us58wwmp 4345 2 : : : cord-015306-us58wwmp 4346 1 We -PRON- PRP cord-015306-us58wwmp 4346 2 retrieved retrieve VBD cord-015306-us58wwmp 4346 3 the the DT cord-015306-us58wwmp 4346 4 data datum NNS cord-015306-us58wwmp 4346 5 of of IN cord-015306-us58wwmp 4346 6 188 188 CD cord-015306-us58wwmp 4346 7 pediatric pediatric JJ cord-015306-us58wwmp 4346 8 recipients recipient NNS cord-015306-us58wwmp 4346 9 since since IN cord-015306-us58wwmp 4346 10 1997 1997 CD cord-015306-us58wwmp 4346 11 ( ( -LRB- cord-015306-us58wwmp 4346 12 110 110 CD cord-015306-us58wwmp 4346 13 boys boy NNS cord-015306-us58wwmp 4346 14 , , , cord-015306-us58wwmp 4346 15 median median JJ cord-015306-us58wwmp 4346 16 age age NN cord-015306-us58wwmp 4346 17 at at IN cord-015306-us58wwmp 4346 18 KTx KTx NNS cord-015306-us58wwmp 4346 19 8.2 8.2 CD cord-015306-us58wwmp 4346 20 years year NNS cord-015306-us58wwmp 4346 21 , , , cord-015306-us58wwmp 4346 22 living live VBG cord-015306-us58wwmp 4346 23 KTx KTx NNPS cord-015306-us58wwmp 4346 24 170 170 CD cord-015306-us58wwmp 4346 25 , , , cord-015306-us58wwmp 4346 26 pre pre JJ cord-015306-us58wwmp 4346 27 - - JJ cord-015306-us58wwmp 4346 28 emptive emptive JJ cord-015306-us58wwmp 4346 29 KTx KTx NNP cord-015306-us58wwmp 4346 30 26 26 CD cord-015306-us58wwmp 4346 31 , , , cord-015306-us58wwmp 4346 32 EBV EBV NNP cord-015306-us58wwmp 4346 33 - - HYPH cord-015306-us58wwmp 4346 34 seronegative seronegative JJ cord-015306-us58wwmp 4346 35 82 82 CD cord-015306-us58wwmp 4346 36 ) ) -RRB- cord-015306-us58wwmp 4346 37 . . . cord-015306-us58wwmp 4347 1 Among among IN cord-015306-us58wwmp 4347 2 them -PRON- PRP cord-015306-us58wwmp 4347 3 , , , cord-015306-us58wwmp 4347 4 11 11 CD cord-015306-us58wwmp 4347 5 cases case NNS cord-015306-us58wwmp 4347 6 ( ( -LRB- cord-015306-us58wwmp 4347 7 10 10 CD cord-015306-us58wwmp 4347 8 EBVrelated EBVrelated NNP cord-015306-us58wwmp 4347 9 , , , cord-015306-us58wwmp 4347 10 1 1 CD cord-015306-us58wwmp 4347 11 non non JJ cord-015306-us58wwmp 4347 12 - - JJ cord-015306-us58wwmp 4347 13 EBV EBV NNP cord-015306-us58wwmp 4347 14 ) ) -RRB- cord-015306-us58wwmp 4347 15 of of IN cord-015306-us58wwmp 4347 16 PTLD PTLD NNP cord-015306-us58wwmp 4347 17 were be VBD cord-015306-us58wwmp 4347 18 diagnosed diagnose VBN cord-015306-us58wwmp 4347 19 in in IN cord-015306-us58wwmp 4347 20 10 10 CD cord-015306-us58wwmp 4347 21 recipients recipient NNS cord-015306-us58wwmp 4347 22 ( ( -LRB- cord-015306-us58wwmp 4347 23 5.3 5.3 CD cord-015306-us58wwmp 4347 24 % % NN cord-015306-us58wwmp 4347 25 ) ) -RRB- cord-015306-us58wwmp 4347 26 , , , cord-015306-us58wwmp 4347 27 and and CC cord-015306-us58wwmp 4347 28 all all DT cord-015306-us58wwmp 4347 29 cases case NNS cord-015306-us58wwmp 4347 30 were be VBD cord-015306-us58wwmp 4347 31 EBV EBV NNP cord-015306-us58wwmp 4347 32 - - HYPH cord-015306-us58wwmp 4347 33 seronegative seronegative JJ cord-015306-us58wwmp 4347 34 at at IN cord-015306-us58wwmp 4347 35 KTx KTx NNS cord-015306-us58wwmp 4347 36 . . . cord-015306-us58wwmp 4348 1 The the DT cord-015306-us58wwmp 4348 2 median median JJ cord-015306-us58wwmp 4348 3 duration duration NN cord-015306-us58wwmp 4348 4 from from IN cord-015306-us58wwmp 4348 5 KTx KTx NNS cord-015306-us58wwmp 4348 6 to to IN cord-015306-us58wwmp 4348 7 the the DT cord-015306-us58wwmp 4348 8 onset onset NN cord-015306-us58wwmp 4348 9 of of IN cord-015306-us58wwmp 4348 10 PTLD PTLD NNP cord-015306-us58wwmp 4348 11 was be VBD cord-015306-us58wwmp 4348 12 7 7 CD cord-015306-us58wwmp 4348 13 months month NNS cord-015306-us58wwmp 4349 1 ( ( -LRB- cord-015306-us58wwmp 4349 2 range range NN cord-015306-us58wwmp 4349 3 : : : cord-015306-us58wwmp 4349 4 4 4 CD cord-015306-us58wwmp 4349 5 - - SYM cord-015306-us58wwmp 4349 6 101 101 CD cord-015306-us58wwmp 4349 7 months month NNS cord-015306-us58wwmp 4349 8 ) ) -RRB- cord-015306-us58wwmp 4349 9 . . . cord-015306-us58wwmp 4350 1 The the DT cord-015306-us58wwmp 4350 2 most most RBS cord-015306-us58wwmp 4350 3 common common JJ cord-015306-us58wwmp 4350 4 presenting present VBG cord-015306-us58wwmp 4350 5 symptom symptom NN cord-015306-us58wwmp 4350 6 of of IN cord-015306-us58wwmp 4350 7 PTLD PTLD NNP cord-015306-us58wwmp 4350 8 was be VBD cord-015306-us58wwmp 4350 9 abdominal abdominal JJ cord-015306-us58wwmp 4350 10 complaints complaint NNS cord-015306-us58wwmp 4350 11 in in IN cord-015306-us58wwmp 4350 12 9 9 CD cord-015306-us58wwmp 4350 13 cases case NNS cord-015306-us58wwmp 4350 14 , , , cord-015306-us58wwmp 4350 15 followed follow VBN cord-015306-us58wwmp 4350 16 by by IN cord-015306-us58wwmp 4350 17 fever fever NN cord-015306-us58wwmp 4350 18 in in IN cord-015306-us58wwmp 4350 19 3 3 CD cord-015306-us58wwmp 4350 20 , , , cord-015306-us58wwmp 4350 21 superficial superficial JJ cord-015306-us58wwmp 4350 22 lymphadenopathy lymphadenopathy NN cord-015306-us58wwmp 4350 23 in in IN cord-015306-us58wwmp 4350 24 3 3 CD cord-015306-us58wwmp 4350 25 and and CC cord-015306-us58wwmp 4350 26 nasal nasal VB cord-015306-us58wwmp 4350 27 congestion congestion NN cord-015306-us58wwmp 4350 28 in in IN cord-015306-us58wwmp 4350 29 1 1 CD cord-015306-us58wwmp 4350 30 . . . cord-015306-us58wwmp 4351 1 Immunosuppressants immunosuppressant NNS cord-015306-us58wwmp 4351 2 were be VBD cord-015306-us58wwmp 4351 3 reduced reduce VBN cord-015306-us58wwmp 4351 4 in in IN cord-015306-us58wwmp 4351 5 all all DT cord-015306-us58wwmp 4351 6 cases case NNS cord-015306-us58wwmp 4351 7 ; ; : cord-015306-us58wwmp 4351 8 the the DT cord-015306-us58wwmp 4351 9 subsequent subsequent JJ cord-015306-us58wwmp 4351 10 treatment treatment NN cord-015306-us58wwmp 4351 11 consisted consist VBN cord-015306-us58wwmp 4351 12 of of IN cord-015306-us58wwmp 4351 13 antiviral antiviral JJ cord-015306-us58wwmp 4351 14 agents agent NNS cord-015306-us58wwmp 4351 15 + + CC cord-015306-us58wwmp 4351 16 IVIG IVIG NNP cord-015306-us58wwmp 4351 17 ( ( -LRB- cord-015306-us58wwmp 4351 18 3/11 3/11 CD cord-015306-us58wwmp 4351 19 ) ) -RRB- cord-015306-us58wwmp 4351 20 , , , cord-015306-us58wwmp 4351 21 anti anti JJ cord-015306-us58wwmp 4351 22 - - JJ cord-015306-us58wwmp 4351 23 CD20 cd20 JJ cord-015306-us58wwmp 4351 24 monoclonal monoclonal JJ cord-015306-us58wwmp 4351 25 antibody antibody NN cord-015306-us58wwmp 4351 26 ( ( -LRB- cord-015306-us58wwmp 4351 27 5/11 5/11 CD cord-015306-us58wwmp 4351 28 ) ) -RRB- cord-015306-us58wwmp 4351 29 , , , cord-015306-us58wwmp 4351 30 and and CC cord-015306-us58wwmp 4351 31 anti anti JJ cord-015306-us58wwmp 4351 32 - - JJ cord-015306-us58wwmp 4351 33 CD20 cd20 JJ cord-015306-us58wwmp 4351 34 monoclonal monoclonal JJ cord-015306-us58wwmp 4351 35 antibody antibody NN cord-015306-us58wwmp 4351 36 + + CC cord-015306-us58wwmp 4351 37 chemotherapy chemotherapy NN cord-015306-us58wwmp 4351 38 ( ( -LRB- cord-015306-us58wwmp 4351 39 2/11 2/11 CD cord-015306-us58wwmp 4351 40 ) ) -RRB- cord-015306-us58wwmp 4351 41 . . . cord-015306-us58wwmp 4352 1 Only only RB cord-015306-us58wwmp 4352 2 one one CD cord-015306-us58wwmp 4352 3 recipient recipient NN cord-015306-us58wwmp 4352 4 died die VBD cord-015306-us58wwmp 4352 5 due due IN cord-015306-us58wwmp 4352 6 to to IN cord-015306-us58wwmp 4352 7 PTLD PTLD NNP cord-015306-us58wwmp 4352 8 . . . cord-015306-us58wwmp 4353 1 Assessing assess VBG cord-015306-us58wwmp 4353 2 the the DT cord-015306-us58wwmp 4353 3 correlation correlation NN cord-015306-us58wwmp 4353 4 between between IN cord-015306-us58wwmp 4353 5 PTLD PTLD NNP cord-015306-us58wwmp 4353 6 and and CC cord-015306-us58wwmp 4353 7 immunosuppressants immunosuppressant NNS cord-015306-us58wwmp 4353 8 in in IN cord-015306-us58wwmp 4353 9 82 82 CD cord-015306-us58wwmp 4353 10 EBV EBV NNP cord-015306-us58wwmp 4353 11 - - HYPH cord-015306-us58wwmp 4353 12 seronegative seronegative JJ cord-015306-us58wwmp 4353 13 recipients recipient NNS cord-015306-us58wwmp 4353 14 ( ( -LRB- cord-015306-us58wwmp 4353 15 median median JJ cord-015306-us58wwmp 4353 16 age age NN cord-015306-us58wwmp 4353 17 at at IN cord-015306-us58wwmp 4353 18 KTx KTx NNS cord-015306-us58wwmp 4353 19 5.7 5.7 CD cord-015306-us58wwmp 4353 20 years year NNS cord-015306-us58wwmp 4353 21 , , , cord-015306-us58wwmp 4353 22 CyA cya NN cord-015306-us58wwmp 4353 23 39 39 CD cord-015306-us58wwmp 4353 24 , , , cord-015306-us58wwmp 4353 25 Tac Tac NNP cord-015306-us58wwmp 4353 26 43 43 CD cord-015306-us58wwmp 4353 27 , , , cord-015306-us58wwmp 4353 28 MZR MZR NNP cord-015306-us58wwmp 4353 29 26 26 CD cord-015306-us58wwmp 4353 30 , , , cord-015306-us58wwmp 4353 31 MMF MMF NNP cord-015306-us58wwmp 4353 32 56 56 CD cord-015306-us58wwmp 4353 33 , , , cord-015306-us58wwmp 4353 34 IL-2 IL-2 NNP cord-015306-us58wwmp 4353 35 receptor receptor NN cord-015306-us58wwmp 4353 36 antibody antibody NN cord-015306-us58wwmp 4353 37 56 56 CD cord-015306-us58wwmp 4353 38 ) ) -RRB- cord-015306-us58wwmp 4353 39 , , , cord-015306-us58wwmp 4353 40 a a DT cord-015306-us58wwmp 4353 41 significantly significantly RB cord-015306-us58wwmp 4353 42 higher high JJR cord-015306-us58wwmp 4353 43 incidence incidence NN cord-015306-us58wwmp 4353 44 of of IN cord-015306-us58wwmp 4353 45 PTLD PTLD NNP cord-015306-us58wwmp 4353 46 was be VBD cord-015306-us58wwmp 4353 47 associated associate VBN cord-015306-us58wwmp 4353 48 with with IN cord-015306-us58wwmp 4353 49 Tac Tac NNP cord-015306-us58wwmp 4353 50 ( ( -LRB- cord-015306-us58wwmp 4353 51 9/43 9/43 CD cord-015306-us58wwmp 4353 52 ) ) -RRB- cord-015306-us58wwmp 4353 53 than than IN cord-015306-us58wwmp 4353 54 CyA CyA NNP cord-015306-us58wwmp 4353 55 ( ( -LRB- cord-015306-us58wwmp 4353 56 1/39 1/39 CD cord-015306-us58wwmp 4353 57 ) ) -RRB- cord-015306-us58wwmp 4353 58 [ [ -LRB- cord-015306-us58wwmp 4353 59 OR OR NNP cord-015306-us58wwmp 4353 60 18.3 18.3 CD cord-015306-us58wwmp 4353 61 , , , cord-015306-us58wwmp 4353 62 p=0 p=0 NNP cord-015306-us58wwmp 4353 63 .003 .003 CD cord-015306-us58wwmp 4353 64 ] ] -RRB- cord-015306-us58wwmp 4353 65 in in IN cord-015306-us58wwmp 4353 66 multiple multiple JJ cord-015306-us58wwmp 4353 67 logistic logistic JJ cord-015306-us58wwmp 4353 68 regression regression NN cord-015306-us58wwmp 4353 69 analysis analysis NN cord-015306-us58wwmp 4353 70 . . . cord-015306-us58wwmp 4354 1 We -PRON- PRP cord-015306-us58wwmp 4354 2 compared compare VBD cord-015306-us58wwmp 4354 3 the the DT cord-015306-us58wwmp 4354 4 incidence incidence NN cord-015306-us58wwmp 4354 5 of of IN cord-015306-us58wwmp 4354 6 PTLD PTLD NNP cord-015306-us58wwmp 4354 7 , , , cord-015306-us58wwmp 4354 8 median median JJ cord-015306-us58wwmp 4354 9 age age NN cord-015306-us58wwmp 4354 10 at at IN cord-015306-us58wwmp 4354 11 KTx KTx NNS cord-015306-us58wwmp 4354 12 , , , cord-015306-us58wwmp 4354 13 and and CC cord-015306-us58wwmp 4354 14 rate rate NN cord-015306-us58wwmp 4354 15 of of IN cord-015306-us58wwmp 4354 16 EBV EBV NNP cord-015306-us58wwmp 4354 17 - - HYPH cord-015306-us58wwmp 4354 18 seronegativity seronegativity NN cord-015306-us58wwmp 4354 19 in in IN cord-015306-us58wwmp 4354 20 3 3 CD cord-015306-us58wwmp 4354 21 eras era NNS cord-015306-us58wwmp 4354 22 ( ( -LRB- cord-015306-us58wwmp 4354 23 A a NN cord-015306-us58wwmp 4354 24 : : : cord-015306-us58wwmp 4354 25 1997 1997 CD cord-015306-us58wwmp 4354 26 - - SYM cord-015306-us58wwmp 4354 27 2001 2001 CD cord-015306-us58wwmp 4354 28 , , , cord-015306-us58wwmp 4354 29 B b NN cord-015306-us58wwmp 4354 30 : : : cord-015306-us58wwmp 4354 31 2002 2002 CD cord-015306-us58wwmp 4354 32 - - SYM cord-015306-us58wwmp 4354 33 2006 2006 CD cord-015306-us58wwmp 4354 34 , , , cord-015306-us58wwmp 4354 35 C c NN cord-015306-us58wwmp 4354 36 : : : cord-015306-us58wwmp 4354 37 2007 2007 CD cord-015306-us58wwmp 4354 38 - - SYM cord-015306-us58wwmp 4354 39 2011 2011 CD cord-015306-us58wwmp 4354 40 ) ) -RRB- cord-015306-us58wwmp 4354 41 of of IN cord-015306-us58wwmp 4354 42 the the DT cord-015306-us58wwmp 4354 43 study study NN cord-015306-us58wwmp 4354 44 period period NN cord-015306-us58wwmp 4354 45 and and CC cord-015306-us58wwmp 4354 46 found find VBD cord-015306-us58wwmp 4354 47 4%/8.2 4%/8.2 CD cord-015306-us58wwmp 4354 48 yrs/32 yrs/32 NN cord-015306-us58wwmp 4354 49 % % NN cord-015306-us58wwmp 4354 50 in in IN cord-015306-us58wwmp 4354 51 A A NNP cord-015306-us58wwmp 4354 52 , , , cord-015306-us58wwmp 4354 53 3%/7.1 3%/7.1 CD cord-015306-us58wwmp 4354 54 yrs/43 yrs/43 NN cord-015306-us58wwmp 4354 55 % % NN cord-015306-us58wwmp 4354 56 in in IN cord-015306-us58wwmp 4354 57 B b NN cord-015306-us58wwmp 4354 58 , , , cord-015306-us58wwmp 4354 59 and and CC cord-015306-us58wwmp 4354 60 10%/9.0 10%/9.0 CD cord-015306-us58wwmp 4354 61 yrs/55 yrs/55 NNP cord-015306-us58wwmp 4354 62 % % NN cord-015306-us58wwmp 4354 63 in in IN cord-015306-us58wwmp 4354 64 C. C. NNP cord-015306-us58wwmp 4355 1 Thus thus RB cord-015306-us58wwmp 4355 2 the the DT cord-015306-us58wwmp 4355 3 incidence incidence NN cord-015306-us58wwmp 4355 4 of of IN cord-015306-us58wwmp 4355 5 PTLD PTLD NNP cord-015306-us58wwmp 4355 6 increased increase VBD cord-015306-us58wwmp 4355 7 with with IN cord-015306-us58wwmp 4355 8 the the DT cord-015306-us58wwmp 4355 9 increase increase NN cord-015306-us58wwmp 4355 10 in in IN cord-015306-us58wwmp 4355 11 EBV EBV NNP cord-015306-us58wwmp 4355 12 - - HYPH cord-015306-us58wwmp 4355 13 seronegative seronegative JJ cord-015306-us58wwmp 4355 14 recipients recipient NNS cord-015306-us58wwmp 4355 15 . . . cord-015306-us58wwmp 4356 1 Conclusion conclusion NN cord-015306-us58wwmp 4356 2 : : : cord-015306-us58wwmp 4357 1 In in IN cord-015306-us58wwmp 4357 2 our -PRON- PRP$ cord-015306-us58wwmp 4357 3 study study NN cord-015306-us58wwmp 4357 4 , , , cord-015306-us58wwmp 4357 5 maintenance maintenance NN cord-015306-us58wwmp 4357 6 treatment treatment NN cord-015306-us58wwmp 4357 7 with with IN cord-015306-us58wwmp 4357 8 Tac Tac NNP cord-015306-us58wwmp 4357 9 ( ( -LRB- cord-015306-us58wwmp 4357 10 compared compare VBN cord-015306-us58wwmp 4357 11 with with IN cord-015306-us58wwmp 4357 12 CyA CyA NNP cord-015306-us58wwmp 4357 13 ) ) -RRB- cord-015306-us58wwmp 4357 14 is be VBZ cord-015306-us58wwmp 4357 15 associated associate VBN cord-015306-us58wwmp 4357 16 with with IN cord-015306-us58wwmp 4357 17 a a DT cord-015306-us58wwmp 4357 18 higher high JJR cord-015306-us58wwmp 4357 19 risk risk NN cord-015306-us58wwmp 4357 20 for for IN cord-015306-us58wwmp 4357 21 developing develop VBG cord-015306-us58wwmp 4357 22 PTLD PTLD NNP cord-015306-us58wwmp 4357 23 . . . cord-015306-us58wwmp 4358 1 Attention attention NN cord-015306-us58wwmp 4358 2 should should MD cord-015306-us58wwmp 4358 3 be be VB cord-015306-us58wwmp 4358 4 paid pay VBN cord-015306-us58wwmp 4358 5 to to IN cord-015306-us58wwmp 4358 6 the the DT cord-015306-us58wwmp 4358 7 increase increase NN cord-015306-us58wwmp 4358 8 in in IN cord-015306-us58wwmp 4358 9 the the DT cord-015306-us58wwmp 4358 10 EBV EBV NNP cord-015306-us58wwmp 4358 11 - - HYPH cord-015306-us58wwmp 4358 12 seronegative seronegative JJ cord-015306-us58wwmp 4358 13 recipients recipient NNS cord-015306-us58wwmp 4358 14 . . . cord-015306-us58wwmp 4359 1 Abstract abstract JJ cord-015306-us58wwmp 4359 2 # # NN cord-015306-us58wwmp 4359 3 P p NN cord-015306-us58wwmp 4359 4 - - : cord-015306-us58wwmp 4359 5 SAT438 SAT438 NNP cord-015306-us58wwmp 4359 6 Acute acute JJ cord-015306-us58wwmp 4359 7 graft graft NN cord-015306-us58wwmp 4359 8 dysfunction dysfunction NN cord-015306-us58wwmp 4359 9 and and CC cord-015306-us58wwmp 4359 10 encephalitis encephalitis NN cord-015306-us58wwmp 4359 11 post post JJ cord-015306-us58wwmp 4359 12 renal renal JJ cord-015306-us58wwmp 4359 13 transplant transplant NN cord-015306-us58wwmp 4359 14 : : : cord-015306-us58wwmp 4360 1 the the DT cord-015306-us58wwmp 4360 2 role role NN cord-015306-us58wwmp 4360 3 of of IN cord-015306-us58wwmp 4360 4 Epstein Epstein NNP cord-015306-us58wwmp 4360 5 - - HYPH cord-015306-us58wwmp 4360 6 Barr Barr NNP cord-015306-us58wwmp 4360 7 Virus Virus NNP cord-015306-us58wwmp 4360 8 Objective Objective NNP cord-015306-us58wwmp 4360 9 : : : cord-015306-us58wwmp 4360 10 Epstein Epstein NNP cord-015306-us58wwmp 4360 11 - - HYPH cord-015306-us58wwmp 4360 12 Barr Barr NNP cord-015306-us58wwmp 4360 13 Virus Virus NNP cord-015306-us58wwmp 4360 14 ( ( -LRB- cord-015306-us58wwmp 4360 15 EBV EBV NNP cord-015306-us58wwmp 4360 16 ) ) -RRB- cord-015306-us58wwmp 4360 17 has have VBZ cord-015306-us58wwmp 4360 18 been be VBN cord-015306-us58wwmp 4360 19 described describe VBN cord-015306-us58wwmp 4360 20 as as IN cord-015306-us58wwmp 4360 21 a a DT cord-015306-us58wwmp 4360 22 rare rare JJ cord-015306-us58wwmp 4360 23 cause cause NN cord-015306-us58wwmp 4360 24 of of IN cord-015306-us58wwmp 4360 25 acute acute JJ cord-015306-us58wwmp 4360 26 kidney kidney NN cord-015306-us58wwmp 4360 27 injury injury NN cord-015306-us58wwmp 4360 28 and and CC cord-015306-us58wwmp 4360 29 encephalitis encephalitis NN cord-015306-us58wwmp 4360 30 in in IN cord-015306-us58wwmp 4360 31 children child NNS cord-015306-us58wwmp 4360 32 . . . cord-015306-us58wwmp 4361 1 Methods method NNS cord-015306-us58wwmp 4362 1 : : : cord-015306-us58wwmp 4362 2 We -PRON- PRP cord-015306-us58wwmp 4362 3 report report VBP cord-015306-us58wwmp 4362 4 a a DT cord-015306-us58wwmp 4362 5 case case NN cord-015306-us58wwmp 4362 6 of of IN cord-015306-us58wwmp 4362 7 a a DT cord-015306-us58wwmp 4362 8 5 5 CD cord-015306-us58wwmp 4362 9 year year NN cord-015306-us58wwmp 4362 10 old old JJ cord-015306-us58wwmp 4362 11 renal renal JJ cord-015306-us58wwmp 4362 12 transplant transplant NN cord-015306-us58wwmp 4362 13 recipient recipient NN cord-015306-us58wwmp 4362 14 who who WP cord-015306-us58wwmp 4362 15 developed develop VBD cord-015306-us58wwmp 4362 16 acute acute JJ cord-015306-us58wwmp 4362 17 graft graft NN cord-015306-us58wwmp 4362 18 dysfunction dysfunction NN cord-015306-us58wwmp 4362 19 and and CC cord-015306-us58wwmp 4362 20 a a DT cord-015306-us58wwmp 4362 21 significant significant JJ cord-015306-us58wwmp 4362 22 neurological neurological JJ cord-015306-us58wwmp 4362 23 insult insult NN cord-015306-us58wwmp 4362 24 with with IN cord-015306-us58wwmp 4362 25 evidence evidence NN cord-015306-us58wwmp 4362 26 of of IN cord-015306-us58wwmp 4362 27 primary primary JJ cord-015306-us58wwmp 4362 28 EBV EBV NNP cord-015306-us58wwmp 4362 29 infection infection NN cord-015306-us58wwmp 4362 30 . . . cord-015306-us58wwmp 4363 1 Results result NNS cord-015306-us58wwmp 4363 2 : : : cord-015306-us58wwmp 4364 1 The the DT cord-015306-us58wwmp 4364 2 patient patient NN cord-015306-us58wwmp 4364 3 had have VBD cord-015306-us58wwmp 4364 4 been be VBN cord-015306-us58wwmp 4364 5 diagnosed diagnose VBN cord-015306-us58wwmp 4364 6 with with IN cord-015306-us58wwmp 4364 7 posterior posterior JJ cord-015306-us58wwmp 4364 8 urethral urethral JJ cord-015306-us58wwmp 4364 9 valves valve NNS cord-015306-us58wwmp 4364 10 prenatally prenatally RB cord-015306-us58wwmp 4364 11 and and CC cord-015306-us58wwmp 4364 12 received receive VBD cord-015306-us58wwmp 4364 13 a a DT cord-015306-us58wwmp 4364 14 live live JJ cord-015306-us58wwmp 4364 15 related related JJ cord-015306-us58wwmp 4364 16 renal renal JJ cord-015306-us58wwmp 4364 17 transplant transplant NN cord-015306-us58wwmp 4364 18 aged age VBN cord-015306-us58wwmp 4364 19 4 4 CD cord-015306-us58wwmp 4364 20 years year NNS cord-015306-us58wwmp 4364 21 . . . cord-015306-us58wwmp 4365 1 Seven seven CD cord-015306-us58wwmp 4365 2 months month NNS cord-015306-us58wwmp 4365 3 post post JJ cord-015306-us58wwmp 4365 4 - - JJ cord-015306-us58wwmp 4365 5 transplant transplant NN cord-015306-us58wwmp 4365 6 he -PRON- PRP cord-015306-us58wwmp 4365 7 presented present VBD cord-015306-us58wwmp 4365 8 fluid fluid NN cord-015306-us58wwmp 4365 9 overloaded overload VBN cord-015306-us58wwmp 4365 10 , , , cord-015306-us58wwmp 4365 11 oliguric oliguric JJ cord-015306-us58wwmp 4365 12 , , , cord-015306-us58wwmp 4365 13 with with IN cord-015306-us58wwmp 4365 14 significant significant JJ cord-015306-us58wwmp 4365 15 uraemia uraemia NN cord-015306-us58wwmp 4365 16 and and CC cord-015306-us58wwmp 4365 17 hyponatraemia hyponatraemia NN cord-015306-us58wwmp 4365 18 . . . cord-015306-us58wwmp 4366 1 There there EX cord-015306-us58wwmp 4366 2 was be VBD cord-015306-us58wwmp 4366 3 a a DT cord-015306-us58wwmp 4366 4 history history NN cord-015306-us58wwmp 4366 5 of of IN cord-015306-us58wwmp 4366 6 lower low JJR cord-015306-us58wwmp 4366 7 urine urine NN cord-015306-us58wwmp 4366 8 output output NN cord-015306-us58wwmp 4366 9 and and CC cord-015306-us58wwmp 4366 10 sore sore JJ cord-015306-us58wwmp 4366 11 throat throat NN cord-015306-us58wwmp 4366 12 4 4 CD cord-015306-us58wwmp 4366 13 days day NNS cord-015306-us58wwmp 4366 14 before before IN cord-015306-us58wwmp 4366 15 admission admission NN cord-015306-us58wwmp 4366 16 with with IN cord-015306-us58wwmp 4366 17 evidence evidence NN cord-015306-us58wwmp 4366 18 of of IN cord-015306-us58wwmp 4366 19 anaemia anaemia NN cord-015306-us58wwmp 4366 20 with with IN cord-015306-us58wwmp 4366 21 red red JJ cord-015306-us58wwmp 4366 22 blood blood NN cord-015306-us58wwmp 4366 23 cell cell NN cord-015306-us58wwmp 4366 24 fragments fragment NNS cord-015306-us58wwmp 4366 25 , , , cord-015306-us58wwmp 4366 26 thrombocytopenia thrombocytopenia NN cord-015306-us58wwmp 4366 27 , , , cord-015306-us58wwmp 4366 28 mild mild JJ cord-015306-us58wwmp 4366 29 monocytosis monocytosis NN cord-015306-us58wwmp 4366 30 , , , cord-015306-us58wwmp 4366 31 raised raise VBD cord-015306-us58wwmp 4366 32 LDH LDH NNP cord-015306-us58wwmp 4366 33 , , , cord-015306-us58wwmp 4366 34 ALT ALT NNP cord-015306-us58wwmp 4366 35 and and CC cord-015306-us58wwmp 4366 36 splenomegaly splenomegaly NN cord-015306-us58wwmp 4366 37 on on IN cord-015306-us58wwmp 4366 38 presentation presentation NN cord-015306-us58wwmp 4366 39 . . . cord-015306-us58wwmp 4367 1 Haemodialysis Haemodialysis NNP cord-015306-us58wwmp 4367 2 was be VBD cord-015306-us58wwmp 4367 3 commenced commence VBN cord-015306-us58wwmp 4367 4 . . . cord-015306-us58wwmp 4368 1 Primary primary JJ cord-015306-us58wwmp 4368 2 EBV EBV NNP cord-015306-us58wwmp 4368 3 infection infection NN cord-015306-us58wwmp 4368 4 was be VBD cord-015306-us58wwmp 4368 5 subsequently subsequently RB cord-015306-us58wwmp 4368 6 detected detect VBN cord-015306-us58wwmp 4368 7 by by IN cord-015306-us58wwmp 4368 8 serology serology NN cord-015306-us58wwmp 4368 9 and and CC cord-015306-us58wwmp 4368 10 PCR.Renal PCR.Renal NNP cord-015306-us58wwmp 4368 11 biopsy biopsy NNP cord-015306-us58wwmp 4368 12 showed show VBD cord-015306-us58wwmp 4368 13 a a DT cord-015306-us58wwmp 4368 14 picture picture NN cord-015306-us58wwmp 4368 15 of of IN cord-015306-us58wwmp 4368 16 acute acute JJ cord-015306-us58wwmp 4368 17 glomerular glomerular JJ cord-015306-us58wwmp 4368 18 thrombotic thrombotic JJ cord-015306-us58wwmp 4368 19 microangiopathy(figure microangiopathy(figure NN cord-015306-us58wwmp 4368 20 above above IN cord-015306-us58wwmp 4368 21 ) ) -RRB- cord-015306-us58wwmp 4368 22 and and CC cord-015306-us58wwmp 4368 23 acute acute JJ cord-015306-us58wwmp 4368 24 tubular tubular JJ cord-015306-us58wwmp 4368 25 injury injury NN cord-015306-us58wwmp 4368 26 secondary secondary JJ cord-015306-us58wwmp 4368 27 to to IN cord-015306-us58wwmp 4368 28 haemoglobinuria haemoglobinuria NNP cord-015306-us58wwmp 4368 29 . . . cord-015306-us58wwmp 4369 1 Scanty scanty JJ cord-015306-us58wwmp 4369 2 EBER+ EBER+ NNS cord-015306-us58wwmp 4369 3 lymphocytes lymphocyte NNS cord-015306-us58wwmp 4369 4 containing contain VBG cord-015306-us58wwmp 4369 5 EBVencoded EBVencoded NNP cord-015306-us58wwmp 4369 6 small small JJ cord-015306-us58wwmp 4369 7 nuclear nuclear JJ cord-015306-us58wwmp 4369 8 RNA RNA NNP cord-015306-us58wwmp 4369 9 were be VBD cord-015306-us58wwmp 4369 10 also also RB cord-015306-us58wwmp 4369 11 present present JJ cord-015306-us58wwmp 4369 12 . . . cord-015306-us58wwmp 4370 1 Within within IN cord-015306-us58wwmp 4370 2 3 3 CD cord-015306-us58wwmp 4370 3 days day NNS cord-015306-us58wwmp 4370 4 of of IN cord-015306-us58wwmp 4370 5 presentation presentation NN cord-015306-us58wwmp 4370 6 patient patient NN cord-015306-us58wwmp 4370 7 deteriorated deteriorate VBD cord-015306-us58wwmp 4370 8 neurologically neurologically RB cord-015306-us58wwmp 4370 9 developing develop VBG cord-015306-us58wwmp 4370 10 a a DT cord-015306-us58wwmp 4370 11 reduced reduce VBN cord-015306-us58wwmp 4370 12 conscious conscious JJ cord-015306-us58wwmp 4370 13 level level NN cord-015306-us58wwmp 4370 14 , , , cord-015306-us58wwmp 4370 15 dysarthria dysarthria NN cord-015306-us58wwmp 4370 16 , , , cord-015306-us58wwmp 4370 17 decreased decrease VBD cord-015306-us58wwmp 4370 18 motor motor NN cord-015306-us58wwmp 4370 19 power power NN cord-015306-us58wwmp 4370 20 peripherally peripherally RB cord-015306-us58wwmp 4370 21 and and CC cord-015306-us58wwmp 4370 22 an an DT cord-015306-us58wwmp 4370 23 inability inability NN cord-015306-us58wwmp 4370 24 to to TO cord-015306-us58wwmp 4370 25 upward upward JJ cord-015306-us58wwmp 4370 26 gaze gaze NN cord-015306-us58wwmp 4370 27 . . . cord-015306-us58wwmp 4371 1 An an DT cord-015306-us58wwmp 4371 2 MRI MRI NNP cord-015306-us58wwmp 4371 3 brain brain NN cord-015306-us58wwmp 4371 4 demonstrated demonstrate VBD cord-015306-us58wwmp 4371 5 increased increase VBN cord-015306-us58wwmp 4371 6 T2 T2 NNP cord-015306-us58wwmp 4371 7 signal signal NN cord-015306-us58wwmp 4371 8 and and CC cord-015306-us58wwmp 4371 9 mild mild JJ cord-015306-us58wwmp 4371 10 diffusion diffusion NN cord-015306-us58wwmp 4371 11 restriction restriction NN cord-015306-us58wwmp 4371 12 in in IN cord-015306-us58wwmp 4371 13 in in IN cord-015306-us58wwmp 4371 14 the the DT cord-015306-us58wwmp 4371 15 caudate caudate NN cord-015306-us58wwmp 4371 16 nuclei nucleus NNS cord-015306-us58wwmp 4371 17 , , , cord-015306-us58wwmp 4371 18 putamina putamina NNP cord-015306-us58wwmp 4371 19 and and CC cord-015306-us58wwmp 4371 20 ventro ventro JJ cord-015306-us58wwmp 4371 21 - - HYPH cord-015306-us58wwmp 4371 22 lateral lateral JJ cord-015306-us58wwmp 4371 23 thalami thalami NNP cord-015306-us58wwmp 4371 24 . . . cord-015306-us58wwmp 4372 1 This this DT cord-015306-us58wwmp 4372 2 picture picture NN cord-015306-us58wwmp 4372 3 has have VBZ cord-015306-us58wwmp 4372 4 been be VBN cord-015306-us58wwmp 4372 5 previously previously RB cord-015306-us58wwmp 4372 6 described describe VBN cord-015306-us58wwmp 4372 7 in in IN cord-015306-us58wwmp 4372 8 EBV EBV NNP cord-015306-us58wwmp 4372 9 encephalitis encephalitis RB cord-015306-us58wwmp 4372 10 . . . cord-015306-us58wwmp 4373 1 There there EX cord-015306-us58wwmp 4373 2 was be VBD cord-015306-us58wwmp 4373 3 a a DT cord-015306-us58wwmp 4373 4 gradual gradual JJ cord-015306-us58wwmp 4373 5 neurological neurological JJ cord-015306-us58wwmp 4373 6 improvement improvement NN cord-015306-us58wwmp 4373 7 and and CC cord-015306-us58wwmp 4373 8 by by IN cord-015306-us58wwmp 4373 9 day day NN cord-015306-us58wwmp 4373 10 7 7 CD cord-015306-us58wwmp 4373 11 of of IN cord-015306-us58wwmp 4373 12 admission admission NN cord-015306-us58wwmp 4373 13 , , , cord-015306-us58wwmp 4373 14 and and CC cord-015306-us58wwmp 4373 15 6 6 CD cord-015306-us58wwmp 4373 16 doses dose NNS cord-015306-us58wwmp 4373 17 of of IN cord-015306-us58wwmp 4373 18 i.v i.v NNP cord-015306-us58wwmp 4373 19 . . NNP cord-015306-us58wwmp 4373 20 methylprednisolone methylprednisolone NNP cord-015306-us58wwmp 4373 21 , , , cord-015306-us58wwmp 4373 22 the the DT cord-015306-us58wwmp 4373 23 patient patient NN cord-015306-us58wwmp 4373 24 had have VBD cord-015306-us58wwmp 4373 25 a a DT cord-015306-us58wwmp 4373 26 full full JJ cord-015306-us58wwmp 4373 27 neurological neurological JJ cord-015306-us58wwmp 4373 28 recovery recovery NN cord-015306-us58wwmp 4373 29 . . . cord-015306-us58wwmp 4374 1 The the DT cord-015306-us58wwmp 4374 2 number number NN cord-015306-us58wwmp 4374 3 of of IN cord-015306-us58wwmp 4374 4 EBV EBV NNP cord-015306-us58wwmp 4374 5 copies copy NNS cord-015306-us58wwmp 4374 6 has have VBZ cord-015306-us58wwmp 4374 7 subsequently subsequently RB cord-015306-us58wwmp 4374 8 decreased decrease VBN cord-015306-us58wwmp 4374 9 on on IN cord-015306-us58wwmp 4374 10 lower low JJR cord-015306-us58wwmp 4374 11 dose dose NN cord-015306-us58wwmp 4374 12 of of IN cord-015306-us58wwmp 4374 13 immunosuppression immunosuppression NN cord-015306-us58wwmp 4374 14 . . . cord-015306-us58wwmp 4375 1 By by IN cord-015306-us58wwmp 4375 2 week week NN cord-015306-us58wwmp 4375 3 4 4 CD cord-015306-us58wwmp 4375 4 after after IN cord-015306-us58wwmp 4375 5 presentation presentation NN cord-015306-us58wwmp 4375 6 he -PRON- PRP cord-015306-us58wwmp 4375 7 was be VBD cord-015306-us58wwmp 4375 8 no no RB cord-015306-us58wwmp 4375 9 longer long JJR cord-015306-us58wwmp 4375 10 dialysis dialysis NN cord-015306-us58wwmp 4375 11 dependent dependent JJ cord-015306-us58wwmp 4375 12 with with IN cord-015306-us58wwmp 4375 13 creatinine creatinine NN cord-015306-us58wwmp 4375 14 3-fold 3-fold CD cord-015306-us58wwmp 4375 15 higher high JJR cord-015306-us58wwmp 4375 16 than than IN cord-015306-us58wwmp 4375 17 the the DT cord-015306-us58wwmp 4375 18 previous previous JJ cord-015306-us58wwmp 4375 19 baseline baseline NN cord-015306-us58wwmp 4375 20 . . . cord-015306-us58wwmp 4376 1 Conclusion conclusion NN cord-015306-us58wwmp 4376 2 : : : cord-015306-us58wwmp 4377 1 This this DT cord-015306-us58wwmp 4377 2 is be VBZ cord-015306-us58wwmp 4377 3 the the DT cord-015306-us58wwmp 4377 4 first first JJ cord-015306-us58wwmp 4377 5 report report NN cord-015306-us58wwmp 4377 6 of of IN cord-015306-us58wwmp 4377 7 acute acute JJ cord-015306-us58wwmp 4377 8 graft graft NN cord-015306-us58wwmp 4377 9 dysfunction dysfunction NN cord-015306-us58wwmp 4377 10 and and CC cord-015306-us58wwmp 4377 11 encephalitis encephalitis NN cord-015306-us58wwmp 4377 12 due due JJ cord-015306-us58wwmp 4377 13 to to IN cord-015306-us58wwmp 4377 14 primary primary JJ cord-015306-us58wwmp 4377 15 EBV EBV NNP cord-015306-us58wwmp 4377 16 infection infection NN cord-015306-us58wwmp 4377 17 in in IN cord-015306-us58wwmp 4377 18 renal renal JJ cord-015306-us58wwmp 4377 19 transplant transplant NN cord-015306-us58wwmp 4377 20 recipient recipient NN cord-015306-us58wwmp 4377 21 . . . cord-015306-us58wwmp 4378 1 Abstract abstract JJ cord-015306-us58wwmp 4378 2 # # NN cord-015306-us58wwmp 4378 3 P p NN cord-015306-us58wwmp 4378 4 - - HYPH cord-015306-us58wwmp 4378 5 SAT439 SAT439 NNPS cord-015306-us58wwmp 4378 6 Indoleamine Indoleamine NNP cord-015306-us58wwmp 4378 7 2,3-Dioxygenase 2,3-dioxygenase CD cord-015306-us58wwmp 4379 1 ( ( -LRB- cord-015306-us58wwmp 4379 2 Ido Ido NNP cord-015306-us58wwmp 4379 3 ) ) -RRB- cord-015306-us58wwmp 4380 1 As as IN cord-015306-us58wwmp 4380 2 A a DT cord-015306-us58wwmp 4380 3 New New NNP cord-015306-us58wwmp 4380 4 Immunological immunological JJ cord-015306-us58wwmp 4380 5 Marker marker NN cord-015306-us58wwmp 4381 1 In in IN cord-015306-us58wwmp 4381 2 Kidney Kidney NNP cord-015306-us58wwmp 4381 3 Elisa Elisa NNP cord-015306-us58wwmp 4381 4 Loiacono Loiacono NNP cord-015306-us58wwmp 4381 5 1 1 CD cord-015306-us58wwmp 4381 6 , , , cord-015306-us58wwmp 4381 7 Barbara Barbara NNP cord-015306-us58wwmp 4381 8 Votta Votta NNP cord-015306-us58wwmp 4381 9 2 2 CD cord-015306-us58wwmp 4381 10 , , , cord-015306-us58wwmp 4381 11 Alessandro Alessandro NNP cord-015306-us58wwmp 4381 12 Amore Amore NNP cord-015306-us58wwmp 4381 13 1 1 CD cord-015306-us58wwmp 4381 14 , , , cord-015306-us58wwmp 4381 15 Licia Licia NNP cord-015306-us58wwmp 4381 16 Peruzzi Peruzzi NNP cord-015306-us58wwmp 4381 17 1 1 CD cord-015306-us58wwmp 4381 18 , , , cord-015306-us58wwmp 4381 19 Maria Maria NNP cord-015306-us58wwmp 4381 20 Paola Paola NNP cord-015306-us58wwmp 4381 21 Puccinelli Puccinelli NNP cord-015306-us58wwmp 4381 22 2 2 CD cord-015306-us58wwmp 4381 23 , , , cord-015306-us58wwmp 4381 24 Roberta Roberta NNP cord-015306-us58wwmp 4381 25 Camilla Camilla NNP cord-015306-us58wwmp 4381 26 1 1 CD cord-015306-us58wwmp 4381 27 , , , cord-015306-us58wwmp 4381 28 Luca Luca NNP cord-015306-us58wwmp 4381 29 Vergano Vergano NNP cord-015306-us58wwmp 4381 30 1 1 CD cord-015306-us58wwmp 4381 31 , , , cord-015306-us58wwmp 4381 32 Giuliana Giuliana NNP cord-015306-us58wwmp 4381 33 Guido Guido NNP cord-015306-us58wwmp 4381 34 3 3 CD cord-015306-us58wwmp 4381 35 , , , cord-015306-us58wwmp 4381 36 Maria Maria NNP cord-015306-us58wwmp 4381 37 Elena Elena NNP cord-015306-us58wwmp 4381 38 Donadi Donadi NNP cord-015306-us58wwmp 4381 39 1 1 CD cord-015306-us58wwmp 4381 40 , , , cord-015306-us58wwmp 4381 41 Rosanna Rosanna NNP cord-015306-us58wwmp 4381 42 Coppo Coppo NNP cord-015306-us58wwmp 4381 43 1 1 CD cord-015306-us58wwmp 4381 44 1 1 CD cord-015306-us58wwmp 4381 45 Nephrology Nephrology NNP cord-015306-us58wwmp 4381 46 , , , cord-015306-us58wwmp 4381 47 Cittàdella Cittàdella NNP cord-015306-us58wwmp 4381 48 Salute Salute NNP cord-015306-us58wwmp 4381 49 e e NNP cord-015306-us58wwmp 4381 50 dellaScienza dellaScienza NNP cord-015306-us58wwmp 4381 51 . . . cord-015306-us58wwmp 4382 1 Regina Regina NNP cord-015306-us58wwmp 4382 2 Margherita Margherita NNP cord-015306-us58wwmp 4382 3 Children Children NNP cord-015306-us58wwmp 4382 4 's 's POS cord-015306-us58wwmp 4382 5 Hospital Hospital NNP cord-015306-us58wwmp 4382 6 , , , cord-015306-us58wwmp 4382 7 Turin Turin NNP cord-015306-us58wwmp 4382 8 , , , cord-015306-us58wwmp 4382 9 Italy Italy NNP cord-015306-us58wwmp 4382 10 2 2 CD cord-015306-us58wwmp 4382 11 Nephrology Nephrology NNP cord-015306-us58wwmp 4382 12 , , , cord-015306-us58wwmp 4382 13 Cittàdella Cittàdella NNP cord-015306-us58wwmp 4382 14 Salute Salute NNP cord-015306-us58wwmp 4382 15 e e NNP cord-015306-us58wwmp 4382 16 dellaScienza dellaScienza NNP cord-015306-us58wwmp 4382 17 , , , cord-015306-us58wwmp 4382 18 Turin Turin NNP cord-015306-us58wwmp 4382 19 , , , cord-015306-us58wwmp 4382 20 Italy Italy NNP cord-015306-us58wwmp 4382 21 3 3 CD cord-015306-us58wwmp 4382 22 Nephrology Nephrology NNP cord-015306-us58wwmp 4382 23 , , , cord-015306-us58wwmp 4382 24 Sapienza Sapienza NNP cord-015306-us58wwmp 4382 25 University University NNP cord-015306-us58wwmp 4382 26 of of IN cord-015306-us58wwmp 4382 27 Rome Rome NNP cord-015306-us58wwmp 4382 28 , , , cord-015306-us58wwmp 4382 29 Rome Rome NNP cord-015306-us58wwmp 4382 30 , , , cord-015306-us58wwmp 4382 31 ItalyObjective ItalyObjective NNP cord-015306-us58wwmp 4382 32 : : : cord-015306-us58wwmp 4383 1 The the DT cord-015306-us58wwmp 4383 2 enzyme enzyme NN cord-015306-us58wwmp 4383 3 indoleamine indoleamine NN cord-015306-us58wwmp 4383 4 2,3dioxygenase 2,3dioxygenase CD cord-015306-us58wwmp 4383 5 ( ( -LRB- cord-015306-us58wwmp 4383 6 IDO IDO NNP cord-015306-us58wwmp 4383 7 ) ) -RRB- cord-015306-us58wwmp 4383 8 , , , cord-015306-us58wwmp 4383 9 induced induce VBN cord-015306-us58wwmp 4383 10 by by IN cord-015306-us58wwmp 4383 11 interferon interferon NN cord-015306-us58wwmp 4383 12 - - HYPH cord-015306-us58wwmp 4383 13 gamma gamma NN cord-015306-us58wwmp 4383 14 ( ( -LRB- cord-015306-us58wwmp 4383 15 IFN IFN NNP cord-015306-us58wwmp 4383 16 - - HYPH cord-015306-us58wwmp 4383 17 gamma gamma NNP cord-015306-us58wwmp 4383 18 ) ) -RRB- cord-015306-us58wwmp 4383 19 and and CC cord-015306-us58wwmp 4383 20 Toll toll NN cord-015306-us58wwmp 4383 21 - - HYPH cord-015306-us58wwmp 4383 22 like like JJ cord-015306-us58wwmp 4383 23 receptors receptor NNS cord-015306-us58wwmp 4383 24 ( ( -LRB- cord-015306-us58wwmp 4383 25 TLRs TLRs NNP cord-015306-us58wwmp 4383 26 ) ) -RRB- cord-015306-us58wwmp 4383 27 ligands ligand NNS cord-015306-us58wwmp 4383 28 in in IN cord-015306-us58wwmp 4383 29 dendritic dendritic JJ cord-015306-us58wwmp 4383 30 cells cell NNS cord-015306-us58wwmp 4383 31 , , , cord-015306-us58wwmp 4383 32 degrades degrade VBZ cord-015306-us58wwmp 4383 33 the the DT cord-015306-us58wwmp 4383 34 essential essential JJ cord-015306-us58wwmp 4383 35 aminoacid aminoacid JJ cord-015306-us58wwmp 4383 36 tryptophan tryptophan NN cord-015306-us58wwmp 4383 37 ( ( -LRB- cord-015306-us58wwmp 4383 38 Trp Trp NNP cord-015306-us58wwmp 4383 39 ) ) -RRB- cord-015306-us58wwmp 4383 40 to to IN cord-015306-us58wwmp 4383 41 kinurenine kinurenine VB cord-015306-us58wwmp 4383 42 ( ( -LRB- cord-015306-us58wwmp 4383 43 Kyn Kyn NNP cord-015306-us58wwmp 4383 44 ) ) -RRB- cord-015306-us58wwmp 4383 45 . . . cord-015306-us58wwmp 4384 1 Its -PRON- PRP$ cord-015306-us58wwmp 4384 2 activity activity NN cord-015306-us58wwmp 4384 3 is be VBZ cord-015306-us58wwmp 4384 4 estimated estimate VBN cord-015306-us58wwmp 4384 5 by by IN cord-015306-us58wwmp 4384 6 the the DT cord-015306-us58wwmp 4384 7 ratio ratio NN cord-015306-us58wwmp 4384 8 of of IN cord-015306-us58wwmp 4384 9 Kyn Kyn NNP cord-015306-us58wwmp 4384 10 to to IN cord-015306-us58wwmp 4384 11 Trp trp NN cord-015306-us58wwmp 4384 12 concentration concentration NN cord-015306-us58wwmp 4384 13 ( ( -LRB- cord-015306-us58wwmp 4384 14 Kyn Kyn NNP cord-015306-us58wwmp 4384 15 / / SYM cord-015306-us58wwmp 4384 16 Trp).T Trp).T NNP cord-015306-us58wwmp 4384 17 - - HYPH cord-015306-us58wwmp 4384 18 cell cell NN cord-015306-us58wwmp 4384 19 activation activation NN cord-015306-us58wwmp 4384 20 and and CC cord-015306-us58wwmp 4384 21 proliferation proliferation NN cord-015306-us58wwmp 4384 22 are be VBP cord-015306-us58wwmp 4384 23 affected affect VBN cord-015306-us58wwmp 4384 24 by by IN cord-015306-us58wwmp 4384 25 Trp trp NN cord-015306-us58wwmp 4384 26 deprivation deprivation NN cord-015306-us58wwmp 4384 27 and and CC cord-015306-us58wwmp 4384 28 accumulation accumulation NN cord-015306-us58wwmp 4384 29 of of IN cord-015306-us58wwmp 4384 30 Kyn Kyn NNP cord-015306-us58wwmp 4384 31 . . . cord-015306-us58wwmp 4385 1 Therefore therefore RB cord-015306-us58wwmp 4385 2 , , , cord-015306-us58wwmp 4385 3 activating activate VBG cord-015306-us58wwmp 4385 4 IDO IDO NNP cord-015306-us58wwmp 4385 5 during during IN cord-015306-us58wwmp 4385 6 immune immune JJ cord-015306-us58wwmp 4385 7 responses response NNS cord-015306-us58wwmp 4385 8 counter counter NN cord-015306-us58wwmp 4385 9 balances balance VBZ cord-015306-us58wwmp 4385 10 mechanism mechanism NN cord-015306-us58wwmp 4385 11 of of IN cord-015306-us58wwmp 4385 12 negative negative JJ cord-015306-us58wwmp 4385 13 feedback feedback NN cord-015306-us58wwmp 4385 14 loop loop NN cord-015306-us58wwmp 4385 15 of of IN cord-015306-us58wwmp 4385 16 IFN IFN NNP cord-015306-us58wwmp 4385 17 - - HYPH cord-015306-us58wwmp 4385 18 gamma gamma NN cord-015306-us58wwmp 4385 19 and and CC cord-015306-us58wwmp 4385 20 acts act VBZ cord-015306-us58wwmp 4385 21 as as IN cord-015306-us58wwmp 4385 22 a a DT cord-015306-us58wwmp 4385 23 tool tool NN cord-015306-us58wwmp 4385 24 to to TO cord-015306-us58wwmp 4385 25 downregulate downregulate VB cord-015306-us58wwmp 4385 26 overwhelming overwhelming JJ cord-015306-us58wwmp 4385 27 immune immune JJ cord-015306-us58wwmp 4385 28 activation activation NN cord-015306-us58wwmp 4385 29 . . . cord-015306-us58wwmp 4386 1 IDO IDO NNP cord-015306-us58wwmp 4386 2 activation activation NN cord-015306-us58wwmp 4386 3 has have VBZ cord-015306-us58wwmp 4386 4 been be VBN cord-015306-us58wwmp 4386 5 reported report VBN cord-015306-us58wwmp 4386 6 to to TO cord-015306-us58wwmp 4386 7 be be VB cord-015306-us58wwmp 4386 8 increased increase VBN cord-015306-us58wwmp 4386 9 in in IN cord-015306-us58wwmp 4386 10 acute acute JJ cord-015306-us58wwmp 4386 11 rejection rejection NN cord-015306-us58wwmp 4386 12 and and CC cord-015306-us58wwmp 4386 13 downregulated downregulate VBN cord-015306-us58wwmp 4386 14 in in IN cord-015306-us58wwmp 4386 15 vitro vitro FW cord-015306-us58wwmp 4386 16 by by IN cord-015306-us58wwmp 4386 17 the the DT cord-015306-us58wwmp 4386 18 immunesuppressants immunesuppressant NNS cord-015306-us58wwmp 4386 19 adopted adopt VBN cord-015306-us58wwmp 4386 20 for for IN cord-015306-us58wwmp 4386 21 organ organ NN cord-015306-us58wwmp 4386 22 transplantation transplantation NN cord-015306-us58wwmp 4386 23 . . . cord-015306-us58wwmp 4387 1 Objective objective NN cord-015306-us58wwmp 4387 2 : : : cord-015306-us58wwmp 4387 3 To to TO cord-015306-us58wwmp 4387 4 determine determine VB cord-015306-us58wwmp 4387 5 the the DT cord-015306-us58wwmp 4387 6 prevalence prevalence NN cord-015306-us58wwmp 4387 7 of of IN cord-015306-us58wwmp 4387 8 mycophenolic mycophenolic JJ cord-015306-us58wwmp 4387 9 acid acid NN cord-015306-us58wwmp 4387 10 ( ( -LRB- cord-015306-us58wwmp 4387 11 Myfortic Myfortic NNP cord-015306-us58wwmp 4387 12 ) ) -RRB- cord-015306-us58wwmp 4387 13 use use NN cord-015306-us58wwmp 4387 14 as as IN cord-015306-us58wwmp 4387 15 part part NN cord-015306-us58wwmp 4387 16 of of IN cord-015306-us58wwmp 4387 17 the the DT cord-015306-us58wwmp 4387 18 immunosuppressant immunosuppressant JJ cord-015306-us58wwmp 4387 19 regime regime NN cord-015306-us58wwmp 4387 20 in in IN cord-015306-us58wwmp 4387 21 our -PRON- PRP$ cord-015306-us58wwmp 4387 22 current current JJ cord-015306-us58wwmp 4387 23 paediatric paediatric JJ cord-015306-us58wwmp 4387 24 renal renal JJ cord-015306-us58wwmp 4387 25 transplant transplant NN cord-015306-us58wwmp 4387 26 recipients recipient NNS cord-015306-us58wwmp 4387 27 in in IN cord-015306-us58wwmp 4387 28 a a DT cord-015306-us58wwmp 4387 29 single single JJ cord-015306-us58wwmp 4387 30 tertiary tertiary JJ cord-015306-us58wwmp 4387 31 paediatric paediatric JJ cord-015306-us58wwmp 4387 32 nephrology nephrology NN cord-015306-us58wwmp 4387 33 centre centre NN cord-015306-us58wwmp 4387 34 and and CC cord-015306-us58wwmp 4387 35 examine examine VB cord-015306-us58wwmp 4387 36 the the DT cord-015306-us58wwmp 4387 37 demography demography NN cord-015306-us58wwmp 4387 38 of of IN cord-015306-us58wwmp 4387 39 these these DT cord-015306-us58wwmp 4387 40 cases case NNS cord-015306-us58wwmp 4387 41 . . . cord-015306-us58wwmp 4388 1 Method method NN cord-015306-us58wwmp 4388 2 : : : cord-015306-us58wwmp 4389 1 Case case NN cord-015306-us58wwmp 4389 2 note note NN cord-015306-us58wwmp 4389 3 and and CC cord-015306-us58wwmp 4389 4 pharmacy pharmacy NN cord-015306-us58wwmp 4389 5 record record NN cord-015306-us58wwmp 4389 6 review review NN cord-015306-us58wwmp 4389 7 of of IN cord-015306-us58wwmp 4389 8 all all DT cord-015306-us58wwmp 4389 9 paediatric paediatric JJ cord-015306-us58wwmp 4389 10 renal renal JJ cord-015306-us58wwmp 4389 11 transplant transplant NN cord-015306-us58wwmp 4389 12 recipients recipient NNS cord-015306-us58wwmp 4389 13 ' ' POS cord-015306-us58wwmp 4389 14 history history NN cord-015306-us58wwmp 4389 15 , , , cord-015306-us58wwmp 4389 16 immunosuppressant immunosuppressant JJ cord-015306-us58wwmp 4389 17 medication medication NN cord-015306-us58wwmp 4389 18 and and CC cord-015306-us58wwmp 4389 19 current current JJ cord-015306-us58wwmp 4389 20 renal renal JJ cord-015306-us58wwmp 4389 21 allograft allograft NN cord-015306-us58wwmp 4389 22 function function NN cord-015306-us58wwmp 4389 23 in in IN cord-015306-us58wwmp 4389 24 January January NNP cord-015306-us58wwmp 4389 25 2013 2013 CD cord-015306-us58wwmp 4389 26 . . . cord-015306-us58wwmp 4390 1 Indication indication NN cord-015306-us58wwmp 4390 2 for for IN cord-015306-us58wwmp 4390 3 medication medication NN cord-015306-us58wwmp 4390 4 switch switch NN cord-015306-us58wwmp 4390 5 from from IN cord-015306-us58wwmp 4390 6 mycophenolatemofetil mycophenolatemofetil NNP cord-015306-us58wwmp 4390 7 to to IN cord-015306-us58wwmp 4390 8 enteric enteric JJ cord-015306-us58wwmp 4390 9 - - HYPH cord-015306-us58wwmp 4390 10 coated coat VBN cord-015306-us58wwmp 4390 11 mycophenolic mycophenolic JJ cord-015306-us58wwmp 4390 12 acid acid NN cord-015306-us58wwmp 4390 13 tablets tablet NNS cord-015306-us58wwmp 4390 14 ( ( -LRB- cord-015306-us58wwmp 4390 15 Myfortic Myfortic NNP cord-015306-us58wwmp 4390 16 ) ) -RRB- cord-015306-us58wwmp 4390 17 was be VBD cord-015306-us58wwmp 4390 18 noted note VBN cord-015306-us58wwmp 4390 19 . . . cord-015306-us58wwmp 4391 1 Data datum NNS cord-015306-us58wwmp 4391 2 presented present VBN cord-015306-us58wwmp 4391 3 as as IN cord-015306-us58wwmp 4391 4 median median JJ cord-015306-us58wwmp 4391 5 ( ( -LRB- cord-015306-us58wwmp 4391 6 range range NN cord-015306-us58wwmp 4391 7 ) ) -RRB- cord-015306-us58wwmp 4391 8 . . . cord-015306-us58wwmp 4392 1 Results result NNS cord-015306-us58wwmp 4392 2 : : : cord-015306-us58wwmp 4392 3 14 14 CD cord-015306-us58wwmp 4392 4 ( ( -LRB- cord-015306-us58wwmp 4392 5 10 10 CD cord-015306-us58wwmp 4392 6 male male NN cord-015306-us58wwmp 4392 7 ) ) -RRB- cord-015306-us58wwmp 4392 8 out out IN cord-015306-us58wwmp 4392 9 of of IN cord-015306-us58wwmp 4392 10 a a DT cord-015306-us58wwmp 4392 11 total total NN cord-015306-us58wwmp 4392 12 of of IN cord-015306-us58wwmp 4392 13 88 88 CD cord-015306-us58wwmp 4392 14 patients patient NNS cord-015306-us58wwmp 4392 15 with with IN cord-015306-us58wwmp 4392 16 renal renal JJ cord-015306-us58wwmp 4392 17 transplants transplant NNS cord-015306-us58wwmp 4392 18 are be VBP cord-015306-us58wwmp 4392 19 currently currently RB cord-015306-us58wwmp 4392 20 receiving receive VBG cord-015306-us58wwmp 4392 21 Myfortic Myfortic NNP cord-015306-us58wwmp 4392 22 in in IN cord-015306-us58wwmp 4392 23 our -PRON- PRP$ cord-015306-us58wwmp 4392 24 centre centre NN cord-015306-us58wwmp 4392 25 . . . cord-015306-us58wwmp 4393 1 Age age NN cord-015306-us58wwmp 4393 2 and and CC cord-015306-us58wwmp 4393 3 time time NN cord-015306-us58wwmp 4393 4 from from IN cord-015306-us58wwmp 4393 5 transplant transplant NN cord-015306-us58wwmp 4393 6 was be VBD cord-015306-us58wwmp 4393 7 12.3 12.3 CD cord-015306-us58wwmp 4393 8 ( ( -LRB- cord-015306-us58wwmp 4393 9 8 8 CD cord-015306-us58wwmp 4393 10 . . CD cord-015306-us58wwmp 4393 11 1 1 CD cord-015306-us58wwmp 4393 12 - - SYM cord-015306-us58wwmp 4393 13 17.4 17.4 CD cord-015306-us58wwmp 4393 14 ) ) -RRB- cord-015306-us58wwmp 4393 15 years year NNS cord-015306-us58wwmp 4393 16 and and CC cord-015306-us58wwmp 4393 17 4.3 4.3 CD cord-015306-us58wwmp 4393 18 ( ( -LRB- cord-015306-us58wwmp 4393 19 0.68 0.68 CD cord-015306-us58wwmp 4393 20 - - SYM cord-015306-us58wwmp 4393 21 10.6 10.6 CD cord-015306-us58wwmp 4393 22 ) ) -RRB- cord-015306-us58wwmp 4393 23 years year NNS cord-015306-us58wwmp 4393 24 . . . cord-015306-us58wwmp 4394 1 The the DT cord-015306-us58wwmp 4394 2 most most RBS cord-015306-us58wwmp 4394 3 common common JJ cord-015306-us58wwmp 4394 4 cause cause NN cord-015306-us58wwmp 4394 5 of of IN cord-015306-us58wwmp 4394 6 end end NN cord-015306-us58wwmp 4394 7 stage stage NN cord-015306-us58wwmp 4394 8 renal renal JJ cord-015306-us58wwmp 4394 9 disease disease NN cord-015306-us58wwmp 4394 10 requiring require VBG cord-015306-us58wwmp 4394 11 transplantation transplantation NN cord-015306-us58wwmp 4394 12 in in IN cord-015306-us58wwmp 4394 13 this this DT cord-015306-us58wwmp 4394 14 subgroup subgroup NN cord-015306-us58wwmp 4394 15 was be VBD cord-015306-us58wwmp 4394 16 posterior posterior JJ cord-015306-us58wwmp 4394 17 urethral urethral JJ cord-015306-us58wwmp 4394 18 valves valve NNS cord-015306-us58wwmp 4394 19 in in IN cord-015306-us58wwmp 4394 20 5/14 5/14 CD cord-015306-us58wwmp 4394 21 cases case NNS cord-015306-us58wwmp 4394 22 . . . cord-015306-us58wwmp 4395 1 Two two CD cord-015306-us58wwmp 4395 2 of of IN cord-015306-us58wwmp 4395 3 these these DT cord-015306-us58wwmp 4395 4 recipients recipient NNS cord-015306-us58wwmp 4395 5 had have VBD cord-015306-us58wwmp 4395 6 ABO ABO NNP cord-015306-us58wwmp 4395 7 incompatible incompatible JJ cord-015306-us58wwmp 4395 8 living live VBG cord-015306-us58wwmp 4395 9 related related JJ cord-015306-us58wwmp 4395 10 transplants transplant NNS cord-015306-us58wwmp 4395 11 . . . cord-015306-us58wwmp 4396 1 Current current JJ cord-015306-us58wwmp 4396 2 eGFR egfr NN cord-015306-us58wwmp 4396 3 was be VBD cord-015306-us58wwmp 4396 4 46.7 46.7 CD cord-015306-us58wwmp 4396 5 ( ( -LRB- cord-015306-us58wwmp 4396 6 20.9 20.9 CD cord-015306-us58wwmp 4396 7 - - HYPH cord-015306-us58wwmp 4396 8 82.3 82.3 CD cord-015306-us58wwmp 4396 9 ) ) -RRB- cord-015306-us58wwmp 4397 1 ml ml NNP cord-015306-us58wwmp 4397 2 / / SYM cord-015306-us58wwmp 4397 3 min/1.73m2 min/1.73m2 NNP cord-015306-us58wwmp 4397 4 . . . cord-015306-us58wwmp 4398 1 13/14 13/14 CD cord-015306-us58wwmp 4398 2 patients patient NNS cord-015306-us58wwmp 4398 3 receiving receive VBG cord-015306-us58wwmp 4398 4 Myfortic Myfortic NNP cord-015306-us58wwmp 4398 5 were be VBD cord-015306-us58wwmp 4398 6 also also RB cord-015306-us58wwmp 4398 7 receiving receive VBG cord-015306-us58wwmp 4398 8 prednisolone prednisolone NN cord-015306-us58wwmp 4398 9 and and CC cord-015306-us58wwmp 4398 10 tacrolimus tacrolimus NN cord-015306-us58wwmp 4398 11 as as IN cord-015306-us58wwmp 4398 12 part part NN cord-015306-us58wwmp 4398 13 of of IN cord-015306-us58wwmp 4398 14 their -PRON- PRP$ cord-015306-us58wwmp 4398 15 immunosuppression immunosuppression NN cord-015306-us58wwmp 4398 16 regime regime NN cord-015306-us58wwmp 4398 17 . . . cord-015306-us58wwmp 4399 1 One one CD cord-015306-us58wwmp 4399 2 patient patient NN cord-015306-us58wwmp 4399 3 was be VBD cord-015306-us58wwmp 4399 4 on on IN cord-015306-us58wwmp 4399 5 tacrolimus tacrolimus NN cord-015306-us58wwmp 4399 6 and and CC cord-015306-us58wwmp 4399 7 Myforctic Myforctic NNP cord-015306-us58wwmp 4399 8 only only RB cord-015306-us58wwmp 4399 9 ( ( -LRB- cord-015306-us58wwmp 4399 10 history history NN cord-015306-us58wwmp 4399 11 of of IN cord-015306-us58wwmp 4399 12 idiopathic idiopathic JJ cord-015306-us58wwmp 4399 13 intracranial intracranial JJ cord-015306-us58wwmp 4399 14 hypertension hypertension NN cord-015306-us58wwmp 4399 15 ) ) -RRB- cord-015306-us58wwmp 4399 16 . . . cord-015306-us58wwmp 4400 1 Dosage dosage NN cord-015306-us58wwmp 4400 2 of of IN cord-015306-us58wwmp 4400 3 Myfortic Myfortic NNP cord-015306-us58wwmp 4400 4 varied varied JJ cord-015306-us58wwmp 4400 5 based base VBN cord-015306-us58wwmp 4400 6 on on IN cord-015306-us58wwmp 4400 7 patient patient JJ cord-015306-us58wwmp 4400 8 size size NN cord-015306-us58wwmp 4400 9 from from IN cord-015306-us58wwmp 4400 10 180 180 CD cord-015306-us58wwmp 4400 11 mg mg NNS cord-015306-us58wwmp 4400 12 twice twice RB cord-015306-us58wwmp 4400 13 daily daily RB cord-015306-us58wwmp 4400 14 to to IN cord-015306-us58wwmp 4400 15 720 720 CD cord-015306-us58wwmp 4400 16 mg mg NN cord-015306-us58wwmp 4400 17 twice twice RB cord-015306-us58wwmp 4400 18 daily daily RB cord-015306-us58wwmp 4400 19 . . . cord-015306-us58wwmp 4401 1 The the DT cord-015306-us58wwmp 4401 2 indication indication NN cord-015306-us58wwmp 4401 3 for for IN cord-015306-us58wwmp 4401 4 carrying carry VBG cord-015306-us58wwmp 4401 5 out out RP cord-015306-us58wwmp 4401 6 a a DT cord-015306-us58wwmp 4401 7 medication medication NN cord-015306-us58wwmp 4401 8 switch switch NN cord-015306-us58wwmp 4401 9 from from IN cord-015306-us58wwmp 4401 10 mycophenolatemofetil mycophenolatemofetil NNP cord-015306-us58wwmp 4401 11 to to IN cord-015306-us58wwmp 4401 12 Myfortic Myfortic NNP cord-015306-us58wwmp 4401 13 was be VBD cord-015306-us58wwmp 4401 14 related relate VBN cord-015306-us58wwmp 4401 15 to to IN cord-015306-us58wwmp 4401 16 gastrointestinal gastrointestinal JJ cord-015306-us58wwmp 4401 17 symptoms symptom NNS cord-015306-us58wwmp 4401 18 in in IN cord-015306-us58wwmp 4401 19 all all DT cord-015306-us58wwmp 4401 20 cases case NNS cord-015306-us58wwmp 4401 21 ; ; : cord-015306-us58wwmp 4401 22 specifically specifically RB cord-015306-us58wwmp 4401 23 diarrhoea diarrhoea VB cord-015306-us58wwmp 4401 24 in in IN cord-015306-us58wwmp 4401 25 9 9 CD cord-015306-us58wwmp 4401 26 cases case NNS cord-015306-us58wwmp 4401 27 , , , cord-015306-us58wwmp 4401 28 abdominal abdominal JJ cord-015306-us58wwmp 4401 29 pain pain NN cord-015306-us58wwmp 4401 30 in in IN cord-015306-us58wwmp 4401 31 2 2 CD cord-015306-us58wwmp 4401 32 cases case NNS cord-015306-us58wwmp 4401 33 and and CC cord-015306-us58wwmp 4401 34 both both DT cord-015306-us58wwmp 4401 35 symptoms symptom NNS cord-015306-us58wwmp 4401 36 in in IN cord-015306-us58wwmp 4401 37 3 3 CD cord-015306-us58wwmp 4401 38 cases case NNS cord-015306-us58wwmp 4401 39 . . . cord-015306-us58wwmp 4402 1 These these DT cord-015306-us58wwmp 4402 2 symptoms symptom NNS cord-015306-us58wwmp 4402 3 improved improve VBD cord-015306-us58wwmp 4402 4 on on IN cord-015306-us58wwmp 4402 5 Myfortic Myfortic NNP cord-015306-us58wwmp 4402 6 with with IN cord-015306-us58wwmp 4402 7 renal renal JJ cord-015306-us58wwmp 4402 8 allograft allograft NN cord-015306-us58wwmp 4402 9 function function NN cord-015306-us58wwmp 4402 10 remaining remain VBG cord-015306-us58wwmp 4402 11 stable stable JJ cord-015306-us58wwmp 4402 12 , , , cord-015306-us58wwmp 4402 13 however however RB cord-015306-us58wwmp 4402 14 in in IN cord-015306-us58wwmp 4402 15 view view NN cord-015306-us58wwmp 4402 16 of of IN cord-015306-us58wwmp 4402 17 neutropenia neutropenia NN cord-015306-us58wwmp 4402 18 in in IN cord-015306-us58wwmp 4402 19 one one CD cord-015306-us58wwmp 4402 20 patient patient NN cord-015306-us58wwmp 4402 21 her -PRON- PRP$ cord-015306-us58wwmp 4402 22 Myfortic Myfortic NNP cord-015306-us58wwmp 4402 23 is be VBZ cord-015306-us58wwmp 4402 24 currently currently RB cord-015306-us58wwmp 4402 25 suspended suspend VBN cord-015306-us58wwmp 4402 26 and and CC cord-015306-us58wwmp 4402 27 under under IN cord-015306-us58wwmp 4402 28 review review NN cord-015306-us58wwmp 4402 29 . . . cord-015306-us58wwmp 4403 1 We -PRON- PRP cord-015306-us58wwmp 4403 2 have have VBP cord-015306-us58wwmp 4403 3 found find VBN cord-015306-us58wwmp 4403 4 that that IN cord-015306-us58wwmp 4403 5 enteric enteric JJ cord-015306-us58wwmp 4403 6 - - HYPH cord-015306-us58wwmp 4403 7 coated coat VBN cord-015306-us58wwmp 4403 8 mycophenolic mycophenolic JJ cord-015306-us58wwmp 4403 9 acid acid NN cord-015306-us58wwmp 4403 10 ( ( -LRB- cord-015306-us58wwmp 4403 11 Myfortic Myfortic NNP cord-015306-us58wwmp 4403 12 ) ) -RRB- cord-015306-us58wwmp 4403 13 was be VBD cord-015306-us58wwmp 4403 14 a a DT cord-015306-us58wwmp 4403 15 well well RB cord-015306-us58wwmp 4403 16 - - HYPH cord-015306-us58wwmp 4403 17 tolerated tolerate VBN cord-015306-us58wwmp 4403 18 alternative alternative NN cord-015306-us58wwmp 4403 19 in in IN cord-015306-us58wwmp 4403 20 paediatric paediatric JJ cord-015306-us58wwmp 4403 21 renal renal JJ cord-015306-us58wwmp 4403 22 allograft allograft NN cord-015306-us58wwmp 4403 23 recipients recipient NNS cord-015306-us58wwmp 4403 24 who who WP cord-015306-us58wwmp 4403 25 developed develop VBD cord-015306-us58wwmp 4403 26 gastrointestinal gastrointestinal JJ cord-015306-us58wwmp 4403 27 symptoms symptom NNS cord-015306-us58wwmp 4403 28 whilst whilst IN cord-015306-us58wwmp 4403 29 receiving receive VBG cord-015306-us58wwmp 4403 30 mycophenolatemofetil mycophenolatemofetil NNP cord-015306-us58wwmp 4403 31 . . . cord-015306-us58wwmp 4404 1 Its -PRON- PRP$ cord-015306-us58wwmp 4404 2 usage usage NN cord-015306-us58wwmp 4404 3 should should MD cord-015306-us58wwmp 4404 4 be be VB cord-015306-us58wwmp 4404 5 considered consider VBN cord-015306-us58wwmp 4404 6 in in IN cord-015306-us58wwmp 4404 7 such such JJ cord-015306-us58wwmp 4404 8 patients patient NNS cord-015306-us58wwmp 4404 9 who who WP cord-015306-us58wwmp 4404 10 are be VBP cord-015306-us58wwmp 4404 11 able able JJ cord-015306-us58wwmp 4404 12 to to TO cord-015306-us58wwmp 4404 13 take take VB cord-015306-us58wwmp 4404 14 tablet tablet NN cord-015306-us58wwmp 4404 15 preparations preparation NNS cord-015306-us58wwmp 4404 16 . . . cord-015306-us58wwmp 4405 1 Ferretti Ferretti NNP cord-015306-us58wwmp 4405 2 Alfonso Alfonso NNP cord-015306-us58wwmp 4405 3 , , , cord-015306-us58wwmp 4405 4 Ilaria Ilaria NNP cord-015306-us58wwmp 4405 5 Luongo Luongo NNP cord-015306-us58wwmp 4405 6 , , , cord-015306-us58wwmp 4405 7 Bruno Bruno NNP cord-015306-us58wwmp 4405 8 Minale Minale NNP cord-015306-us58wwmp 4405 9 , , , cord-015306-us58wwmp 4405 10 Gabriele Gabriele NNP cord-015306-us58wwmp 4405 11 Malgieri Malgieri NNP cord-015306-us58wwmp 4405 12 , , , cord-015306-us58wwmp 4405 13 Carmine Carmine NNP cord-015306-us58wwmp 4405 14 Pecoraro Pecoraro NNP cord-015306-us58wwmp 4405 15 Nephrology Nephrology NNP cord-015306-us58wwmp 4405 16 and and CC cord-015306-us58wwmp 4405 17 Urology Urology NNP cord-015306-us58wwmp 4405 18 , , , cord-015306-us58wwmp 4405 19 Santobono Santobono NNP cord-015306-us58wwmp 4405 20 Children Children NNP cord-015306-us58wwmp 4405 21 ' ' POS cord-015306-us58wwmp 4405 22 Hospital Hospital NNP cord-015306-us58wwmp 4405 23 , , , cord-015306-us58wwmp 4405 24 Naples Naples NNP cord-015306-us58wwmp 4405 25 , , , cord-015306-us58wwmp 4405 26 ItalyObjective ItalyObjective NNP cord-015306-us58wwmp 4405 27 : : : cord-015306-us58wwmp 4405 28 UTI UTI NNP cord-015306-us58wwmp 4405 29 represent represent VB cord-015306-us58wwmp 4405 30 one one CD cord-015306-us58wwmp 4405 31 of of IN cord-015306-us58wwmp 4405 32 the the DT cord-015306-us58wwmp 4405 33 main main JJ cord-015306-us58wwmp 4405 34 complications complication NNS cord-015306-us58wwmp 4405 35 after after IN cord-015306-us58wwmp 4405 36 KT KT NNP cord-015306-us58wwmp 4405 37 and and CC cord-015306-us58wwmp 4405 38 have have VBP cord-015306-us58wwmp 4405 39 an an DT cord-015306-us58wwmp 4405 40 important important JJ cord-015306-us58wwmp 4405 41 role role NN cord-015306-us58wwmp 4405 42 in in IN cord-015306-us58wwmp 4405 43 graft graft NN cord-015306-us58wwmp 4405 44 funcion funcion NN cord-015306-us58wwmp 4405 45 impairment impairment NN cord-015306-us58wwmp 4405 46 . . . cord-015306-us58wwmp 4406 1 This this DT cord-015306-us58wwmp 4406 2 retrospective retrospective JJ cord-015306-us58wwmp 4406 3 report report NN cord-015306-us58wwmp 4406 4 is be VBZ cord-015306-us58wwmp 4406 5 aimed aim VBN cord-015306-us58wwmp 4406 6 to to TO cord-015306-us58wwmp 4406 7 evaluate evaluate VB cord-015306-us58wwmp 4406 8 the the DT cord-015306-us58wwmp 4406 9 incidence incidence NN cord-015306-us58wwmp 4406 10 of of IN cord-015306-us58wwmp 4406 11 UTI UTI NNP cord-015306-us58wwmp 4406 12 in in IN cord-015306-us58wwmp 4406 13 a a DT cord-015306-us58wwmp 4406 14 group group NN cord-015306-us58wwmp 4406 15 of of IN cord-015306-us58wwmp 4406 16 patients patient NNS cord-015306-us58wwmp 4406 17 attending attend VBG cord-015306-us58wwmp 4406 18 our -PRON- PRP$ cord-015306-us58wwmp 4406 19 hospital hospital NN cord-015306-us58wwmp 4406 20 for for IN cord-015306-us58wwmp 4406 21 post post NN cord-015306-us58wwmp 4406 22 transplant transplant NN cord-015306-us58wwmp 4406 23 usual usual JJ cord-015306-us58wwmp 4406 24 medical medical JJ cord-015306-us58wwmp 4406 25 controls control NNS cord-015306-us58wwmp 4406 26 . . . cord-015306-us58wwmp 4407 1 Methods method NNS cord-015306-us58wwmp 4407 2 and and CC cord-015306-us58wwmp 4407 3 Results result NNS cord-015306-us58wwmp 4407 4 : : : cord-015306-us58wwmp 4407 5 We -PRON- PRP cord-015306-us58wwmp 4407 6 incuded incude VBD cord-015306-us58wwmp 4407 7 in in IN cord-015306-us58wwmp 4407 8 our -PRON- PRP$ cord-015306-us58wwmp 4407 9 study study NN cord-015306-us58wwmp 4407 10 75 75 CD cord-015306-us58wwmp 4407 11 children child NNS cord-015306-us58wwmp 4407 12 who who WP cord-015306-us58wwmp 4407 13 underwent undergo VBD cord-015306-us58wwmp 4407 14 KT KT NNP cord-015306-us58wwmp 4407 15 between between IN cord-015306-us58wwmp 4407 16 2000 2000 CD cord-015306-us58wwmp 4407 17 and and CC cord-015306-us58wwmp 4407 18 2011 2011 CD cord-015306-us58wwmp 4407 19 : : : cord-015306-us58wwmp 4408 1 42 42 CD cord-015306-us58wwmp 4408 2 M M NNP cord-015306-us58wwmp 4408 3 and and CC cord-015306-us58wwmp 4408 4 33 33 CD cord-015306-us58wwmp 4408 5 F F NNP cord-015306-us58wwmp 4408 6 , , , cord-015306-us58wwmp 4408 7 mean mean VB cord-015306-us58wwmp 4408 8 age age NN cord-015306-us58wwmp 4408 9 11.6 11.6 CD cord-015306-us58wwmp 4409 1 + + CC cord-015306-us58wwmp 4409 2 /-5.3 /-5.3 NN cord-015306-us58wwmp 4409 3 . . . cord-015306-us58wwmp 4410 1 Four four CD cord-015306-us58wwmp 4410 2 children child NNS cord-015306-us58wwmp 4410 3 received receive VBD cord-015306-us58wwmp 4410 4 a a DT cord-015306-us58wwmp 4410 5 graft graft NN cord-015306-us58wwmp 4410 6 from from IN cord-015306-us58wwmp 4410 7 a a DT cord-015306-us58wwmp 4410 8 living live VBG cord-015306-us58wwmp 4410 9 related related JJ cord-015306-us58wwmp 4410 10 donor donor NN cord-015306-us58wwmp 4410 11 and and CC cord-015306-us58wwmp 4410 12 71 71 CD cord-015306-us58wwmp 4410 13 from from IN cord-015306-us58wwmp 4410 14 a a DT cord-015306-us58wwmp 4410 15 deceased deceased JJ cord-015306-us58wwmp 4410 16 donor donor NN cord-015306-us58wwmp 4410 17 . . . cord-015306-us58wwmp 4411 1 First first JJ cord-015306-us58wwmp 4411 2 morning morning NN cord-015306-us58wwmp 4411 3 sterile sterile JJ cord-015306-us58wwmp 4411 4 urine urine NN cord-015306-us58wwmp 4411 5 sample sample NN cord-015306-us58wwmp 4411 6 to to IN cord-015306-us58wwmp 4411 7 the the DT cord-015306-us58wwmp 4411 8 microbiology microbiology NN cord-015306-us58wwmp 4411 9 laboratory laboratory NN cord-015306-us58wwmp 4411 10 was be VBD cord-015306-us58wwmp 4411 11 obtained obtain VBN cord-015306-us58wwmp 4411 12 when when WRB cord-015306-us58wwmp 4411 13 attending attend VBG cord-015306-us58wwmp 4411 14 the the DT cord-015306-us58wwmp 4411 15 hospital hospital NN cord-015306-us58wwmp 4411 16 for for IN cord-015306-us58wwmp 4411 17 its -PRON- PRP$ cord-015306-us58wwmp 4411 18 usual usual JJ cord-015306-us58wwmp 4411 19 medical medical JJ cord-015306-us58wwmp 4411 20 control control NN cord-015306-us58wwmp 4411 21 or or CC cord-015306-us58wwmp 4411 22 immunesuppressive immunesuppressive JJ cord-015306-us58wwmp 4411 23 drug drug NN cord-015306-us58wwmp 4411 24 detection detection NN cord-015306-us58wwmp 4411 25 levels level NNS cord-015306-us58wwmp 4411 26 . . . cord-015306-us58wwmp 4412 1 Results result NNS cord-015306-us58wwmp 4412 2 : : : cord-015306-us58wwmp 4412 3 in in IN cord-015306-us58wwmp 4412 4 41 41 CD cord-015306-us58wwmp 4412 5 patients patient NNS cord-015306-us58wwmp 4412 6 ( ( -LRB- cord-015306-us58wwmp 4412 7 54.7 54.7 CD cord-015306-us58wwmp 4412 8 % % NN cord-015306-us58wwmp 4412 9 ) ) -RRB- cord-015306-us58wwmp 4412 10 ESRD ESRD NNP cord-015306-us58wwmp 4412 11 was be VBD cord-015306-us58wwmp 4412 12 secondary secondary JJ cord-015306-us58wwmp 4412 13 to to IN cord-015306-us58wwmp 4412 14 CAKUT CAKUT NNP cord-015306-us58wwmp 4412 15 . . . cord-015306-us58wwmp 4413 1 Thirty thirty CD cord-015306-us58wwmp 4413 2 - - HYPH cord-015306-us58wwmp 4413 3 six six CD cord-015306-us58wwmp 4413 4 patients patient NNS cord-015306-us58wwmp 4413 5 ( ( -LRB- cord-015306-us58wwmp 4413 6 48 48 CD cord-015306-us58wwmp 4413 7 % % NN cord-015306-us58wwmp 4413 8 ) ) -RRB- cord-015306-us58wwmp 4413 9 presented present VBD cord-015306-us58wwmp 4413 10 at at IN cord-015306-us58wwmp 4413 11 least least JJS cord-015306-us58wwmp 4413 12 one one CD cord-015306-us58wwmp 4413 13 episode episode NN cord-015306-us58wwmp 4413 14 of of IN cord-015306-us58wwmp 4413 15 UTI UTI NNP cord-015306-us58wwmp 4413 16 occurred occur VBD cord-015306-us58wwmp 4413 17 in in IN cord-015306-us58wwmp 4413 18 the the DT cord-015306-us58wwmp 4413 19 first first JJ cord-015306-us58wwmp 4413 20 6 6 CD cord-015306-us58wwmp 4413 21 months month NNS cord-015306-us58wwmp 4413 22 after after IN cord-015306-us58wwmp 4413 23 KT KT NNP cord-015306-us58wwmp 4413 24 , , , cord-015306-us58wwmp 4413 25 mainly mainly RB cord-015306-us58wwmp 4413 26 in in IN cord-015306-us58wwmp 4413 27 females female NNS cord-015306-us58wwmp 4413 28 ( ( -LRB- cord-015306-us58wwmp 4413 29 1.2:1 1.2:1 CD cord-015306-us58wwmp 4413 30 ) ) -RRB- cord-015306-us58wwmp 4413 31 . . . cord-015306-us58wwmp 4414 1 UTI UTI NNP cord-015306-us58wwmp 4414 2 developed develop VBD cord-015306-us58wwmp 4414 3 in in IN cord-015306-us58wwmp 4414 4 the the DT cord-015306-us58wwmp 4414 5 first first JJ cord-015306-us58wwmp 4414 6 period period NN cord-015306-us58wwmp 4414 7 were be VBD cord-015306-us58wwmp 4414 8 caused cause VBN cord-015306-us58wwmp 4414 9 mainly mainly RB cord-015306-us58wwmp 4414 10 by by IN cord-015306-us58wwmp 4414 11 Gram Gram NNP cord-015306-us58wwmp 4414 12 negative negative JJ cord-015306-us58wwmp 4414 13 bacteria bacteria NNS cord-015306-us58wwmp 4414 14 ( ( -LRB- cord-015306-us58wwmp 4414 15 91 91 CD cord-015306-us58wwmp 4414 16 % % NN cord-015306-us58wwmp 4414 17 ) ) -RRB- cord-015306-us58wwmp 4414 18 . . . cord-015306-us58wwmp 4415 1 E. E. NNP cord-015306-us58wwmp 4415 2 Coli Coli NNP cord-015306-us58wwmp 4415 3 was be VBD cord-015306-us58wwmp 4415 4 the the DT cord-015306-us58wwmp 4415 5 main main JJ cord-015306-us58wwmp 4415 6 agent agent NN cord-015306-us58wwmp 4415 7 ( ( -LRB- cord-015306-us58wwmp 4415 8 66.1 66.1 CD cord-015306-us58wwmp 4415 9 % % NN cord-015306-us58wwmp 4415 10 ) ) -RRB- cord-015306-us58wwmp 4415 11 , , , cord-015306-us58wwmp 4415 12 the the DT cord-015306-us58wwmp 4415 13 other other JJ cord-015306-us58wwmp 4415 14 uropathogens uropathogen NNS cord-015306-us58wwmp 4415 15 involved involve VBN cord-015306-us58wwmp 4415 16 were be VBD cord-015306-us58wwmp 4415 17 : : : cord-015306-us58wwmp 4415 18 Proteus Proteus NNP cord-015306-us58wwmp 4415 19 ( ( -LRB- cord-015306-us58wwmp 4415 20 9 9 CD cord-015306-us58wwmp 4415 21 % % NN cord-015306-us58wwmp 4415 22 ) ) -RRB- cord-015306-us58wwmp 4415 23 , , , cord-015306-us58wwmp 4415 24 Enterobacter Enterobacter NNP cord-015306-us58wwmp 4415 25 Cloacae Cloacae NNP cord-015306-us58wwmp 4415 26 ( ( -LRB- cord-015306-us58wwmp 4415 27 9 9 CD cord-015306-us58wwmp 4415 28 % % NN cord-015306-us58wwmp 4415 29 ) ) -RRB- cord-015306-us58wwmp 4415 30 , , , cord-015306-us58wwmp 4415 31 Pseudomonas Pseudomonas NNP cord-015306-us58wwmp 4415 32 Aeruginosa Aeruginosa NNP cord-015306-us58wwmp 4415 33 ( ( -LRB- cord-015306-us58wwmp 4415 34 6 6 CD cord-015306-us58wwmp 4415 35 % % NN cord-015306-us58wwmp 4415 36 ) ) -RRB- cord-015306-us58wwmp 4415 37 , , , cord-015306-us58wwmp 4415 38 Candida Candida NNP cord-015306-us58wwmp 4415 39 Albicans albican NNS cord-015306-us58wwmp 4415 40 ( ( -LRB- cord-015306-us58wwmp 4415 41 3.3 3.3 CD cord-015306-us58wwmp 4415 42 % % NN cord-015306-us58wwmp 4415 43 ) ) -RRB- cord-015306-us58wwmp 4415 44 and and CC cord-015306-us58wwmp 4415 45 Klebsiella Klebsiella NNP cord-015306-us58wwmp 4415 46 ( ( -LRB- cord-015306-us58wwmp 4415 47 3.3 3.3 CD cord-015306-us58wwmp 4415 48 % % NN cord-015306-us58wwmp 4415 49 ) ) -RRB- cord-015306-us58wwmp 4415 50 . . . cord-015306-us58wwmp 4416 1 Later later JJ cord-015306-us58wwmp 4416 2 infections infection NNS cord-015306-us58wwmp 4416 3 were be VBD cord-015306-us58wwmp 4416 4 caused cause VBN cord-015306-us58wwmp 4416 5 mainly mainly RB cord-015306-us58wwmp 4416 6 by by IN cord-015306-us58wwmp 4416 7 Candida Candida NNP cord-015306-us58wwmp 4416 8 , , , cord-015306-us58wwmp 4416 9 Klebsiella Klebsiella NNP cord-015306-us58wwmp 4416 10 , , , cord-015306-us58wwmp 4416 11 ProteusansdEnterobacterfaecalis ProteusansdEnterobacterfaecalis NNP cord-015306-us58wwmp 4416 12 . . . cord-015306-us58wwmp 4417 1 One one CD cord-015306-us58wwmp 4417 2 patient patient NN cord-015306-us58wwmp 4417 3 at at IN cord-015306-us58wwmp 4417 4 the the DT cord-015306-us58wwmp 4417 5 15th 15th JJ cord-015306-us58wwmp 4417 6 month month NN cord-015306-us58wwmp 4417 7 post post NN cord-015306-us58wwmp 4417 8 - - NN cord-015306-us58wwmp 4417 9 transplantation transplantation NN cord-015306-us58wwmp 4417 10 manifested manifest VBD cord-015306-us58wwmp 4417 11 UTI UTI NNP cord-015306-us58wwmp 4417 12 caused cause VBN cord-015306-us58wwmp 4417 13 by by IN cord-015306-us58wwmp 4417 14 Corinebacterium Corinebacterium NNP cord-015306-us58wwmp 4417 15 Urealyticum Urealyticum NNP cord-015306-us58wwmp 4417 16 associated associate VBN cord-015306-us58wwmp 4417 17 with with IN cord-015306-us58wwmp 4417 18 concretions concretion NNS cord-015306-us58wwmp 4417 19 of of IN cord-015306-us58wwmp 4417 20 baldder baldder NNP cord-015306-us58wwmp 4417 21 mucosae mucosae NNP cord-015306-us58wwmp 4417 22 . . . cord-015306-us58wwmp 4418 1 Eight eight CD cord-015306-us58wwmp 4418 2 patients patient NNS cord-015306-us58wwmp 4418 3 ( ( -LRB- cord-015306-us58wwmp 4418 4 5 5 CD cord-015306-us58wwmp 4418 5 M m NN cord-015306-us58wwmp 4418 6 and and CC cord-015306-us58wwmp 4418 7 3 3 CD cord-015306-us58wwmp 4418 8 F F NNP cord-015306-us58wwmp 4418 9 ) ) -RRB- cord-015306-us58wwmp 4418 10 experienced experience VBD cord-015306-us58wwmp 4418 11 the the DT cord-015306-us58wwmp 4418 12 graft graft NN cord-015306-us58wwmp 4418 13 loss loss NN cord-015306-us58wwmp 4418 14 : : : cord-015306-us58wwmp 4418 15 4 4 CD cord-015306-us58wwmp 4418 16 patients patient NNS cord-015306-us58wwmp 4418 17 were be VBD cord-015306-us58wwmp 4418 18 affected affect VBN cord-015306-us58wwmp 4418 19 by by IN cord-015306-us58wwmp 4418 20 CAKUT CAKUT NNP cord-015306-us58wwmp 4418 21 and and CC cord-015306-us58wwmp 4418 22 had have VBD cord-015306-us58wwmp 4418 23 febrile febrile JJ cord-015306-us58wwmp 4418 24 UTI UTI NNP cord-015306-us58wwmp 4418 25 postTx postTx NNS cord-015306-us58wwmp 4418 26 . . . cord-015306-us58wwmp 4419 1 One one CD cord-015306-us58wwmp 4419 2 patient patient NN cord-015306-us58wwmp 4419 3 left leave VBD cord-015306-us58wwmp 4419 4 the the DT cord-015306-us58wwmp 4419 5 second second JJ cord-015306-us58wwmp 4419 6 graft graft NN cord-015306-us58wwmp 4419 7 by by IN cord-015306-us58wwmp 4419 8 a a DT cord-015306-us58wwmp 4419 9 an an DT cord-015306-us58wwmp 4419 10 acute acute JJ cord-015306-us58wwmp 4419 11 deterioration deterioration NN cord-015306-us58wwmp 4419 12 of of IN cord-015306-us58wwmp 4419 13 renal renal JJ cord-015306-us58wwmp 4419 14 function function NN cord-015306-us58wwmp 4419 15 during during IN cord-015306-us58wwmp 4419 16 an an DT cord-015306-us58wwmp 4419 17 UTI UTI NNP cord-015306-us58wwmp 4419 18 by by IN cord-015306-us58wwmp 4419 19 BKV BKV NNP cord-015306-us58wwmp 4419 20 . . . cord-015306-us58wwmp 4420 1 Conclusion conclusion NN cord-015306-us58wwmp 4420 2 : : : cord-015306-us58wwmp 4420 3 UTI UTI NNP cord-015306-us58wwmp 4420 4 in in IN cord-015306-us58wwmp 4420 5 Kidney kidney NN cord-015306-us58wwmp 4420 6 transplanted transplant VBN cord-015306-us58wwmp 4420 7 children child NNS cord-015306-us58wwmp 4420 8 represent represent VBP cord-015306-us58wwmp 4420 9 a a DT cord-015306-us58wwmp 4420 10 main main JJ cord-015306-us58wwmp 4420 11 complaint complaint NN cord-015306-us58wwmp 4420 12 as as IN cord-015306-us58wwmp 4420 13 demonstrated demonstrate VBN cord-015306-us58wwmp 4420 14 by by IN cord-015306-us58wwmp 4420 15 the the DT cord-015306-us58wwmp 4420 16 high high JJ cord-015306-us58wwmp 4420 17 incidence incidence NN cord-015306-us58wwmp 4420 18 ( ( -LRB- cord-015306-us58wwmp 4420 19 48 48 CD cord-015306-us58wwmp 4420 20 % % NN cord-015306-us58wwmp 4420 21 ) ) -RRB- cord-015306-us58wwmp 4420 22 in in IN cord-015306-us58wwmp 4420 23 total total JJ cord-015306-us58wwmp 4420 24 population population NN cord-015306-us58wwmp 4420 25 mainly mainly RB cord-015306-us58wwmp 4420 26 in in IN cord-015306-us58wwmp 4420 27 females female NNS cord-015306-us58wwmp 4420 28 . . . cord-015306-us58wwmp 4421 1 A a DT cord-015306-us58wwmp 4421 2 significant significant JJ cord-015306-us58wwmp 4421 3 role role NN cord-015306-us58wwmp 4421 4 is be VBZ cord-015306-us58wwmp 4421 5 played play VBN cord-015306-us58wwmp 4421 6 by by IN cord-015306-us58wwmp 4421 7 primary primary JJ cord-015306-us58wwmp 4421 8 uropathy uropathy NN cord-015306-us58wwmp 4421 9 and and CC cord-015306-us58wwmp 4421 10 immunosuppression immunosuppression NN cord-015306-us58wwmp 4421 11 as as IN cord-015306-us58wwmp 4421 12 demonstrated demonstrate VBN cord-015306-us58wwmp 4421 13 by by IN cord-015306-us58wwmp 4421 14 the the DT cord-015306-us58wwmp 4421 15 high high JJ cord-015306-us58wwmp 4421 16 frequency frequency NN cord-015306-us58wwmp 4421 17 also also RB cord-015306-us58wwmp 4421 18 in in IN cord-015306-us58wwmp 4421 19 non non JJ cord-015306-us58wwmp 4421 20 uropathic uropathic JJ cord-015306-us58wwmp 4421 21 patients patient NNS cord-015306-us58wwmp 4421 22 . . . cord-015306-us58wwmp 4422 1 The the DT cord-015306-us58wwmp 4422 2 role role NN cord-015306-us58wwmp 4422 3 of of IN cord-015306-us58wwmp 4422 4 UTI UTI NNP cord-015306-us58wwmp 4422 5 in in IN cord-015306-us58wwmp 4422 6 longterm longterm JJ cord-015306-us58wwmp 4422 7 outcome outcome NN cord-015306-us58wwmp 4422 8 of of IN cord-015306-us58wwmp 4422 9 KT KT NNP cord-015306-us58wwmp 4422 10 remains remain VBZ cord-015306-us58wwmp 4422 11 controversial controversial JJ cord-015306-us58wwmp 4422 12 . . . cord-015306-us58wwmp 4423 1 Factors factor NNS cord-015306-us58wwmp 4423 2 associated associate VBN cord-015306-us58wwmp 4423 3 with with IN cord-015306-us58wwmp 4423 4 elevated elevated JJ cord-015306-us58wwmp 4423 5 pulse pulse NN cord-015306-us58wwmp 4423 6 wave wave NN cord-015306-us58wwmp 4423 7 velocity velocity NN cord-015306-us58wwmp 4423 8 in in IN cord-015306-us58wwmp 4423 9 children child NNS cord-015306-us58wwmp 4423 10 after after IN cord-015306-us58wwmp 4423 11 renal renal JJ cord-015306-us58wwmp 4423 12 transplantation transplantation NN cord-015306-us58wwmp 4423 13 Objective objective NN cord-015306-us58wwmp 4423 14 : : : cord-015306-us58wwmp 4423 15 Even even RB cord-015306-us58wwmp 4423 16 after after IN cord-015306-us58wwmp 4423 17 successful successful JJ cord-015306-us58wwmp 4423 18 transplantation transplantation NN cord-015306-us58wwmp 4423 19 children child NNS cord-015306-us58wwmp 4423 20 with with IN cord-015306-us58wwmp 4423 21 underlying underlie VBG cord-015306-us58wwmp 4423 22 chronic chronic JJ cord-015306-us58wwmp 4423 23 kidney kidney NN cord-015306-us58wwmp 4423 24 disease disease NN cord-015306-us58wwmp 4423 25 ( ( -LRB- cord-015306-us58wwmp 4423 26 CKD CKD NNP cord-015306-us58wwmp 4423 27 ) ) -RRB- cord-015306-us58wwmp 4423 28 still still RB cord-015306-us58wwmp 4423 29 carry carry VBP cord-015306-us58wwmp 4423 30 a a DT cord-015306-us58wwmp 4423 31 high high JJ cord-015306-us58wwmp 4423 32 cardiovascular cardiovascular JJ cord-015306-us58wwmp 4423 33 risk risk NN cord-015306-us58wwmp 4423 34 . . . cord-015306-us58wwmp 4424 1 This this DT cord-015306-us58wwmp 4424 2 is be VBZ cord-015306-us58wwmp 4424 3 also also RB cord-015306-us58wwmp 4424 4 documented document VBN cord-015306-us58wwmp 4424 5 by by IN cord-015306-us58wwmp 4424 6 cardiovascular cardiovascular JJ cord-015306-us58wwmp 4424 7 death death NN cord-015306-us58wwmp 4424 8 being be VBG cord-015306-us58wwmp 4424 9 the the DT cord-015306-us58wwmp 4424 10 second second JJ cord-015306-us58wwmp 4424 11 leading leading JJ cord-015306-us58wwmp 4424 12 cause cause NN cord-015306-us58wwmp 4424 13 of of IN cord-015306-us58wwmp 4424 14 death death NN cord-015306-us58wwmp 4424 15 after after IN cord-015306-us58wwmp 4424 16 transplantation transplantation NN cord-015306-us58wwmp 4424 17 in in IN cord-015306-us58wwmp 4424 18 this this DT cord-015306-us58wwmp 4424 19 patient patient JJ cord-015306-us58wwmp 4424 20 cohort cohort NN cord-015306-us58wwmp 4424 21 . . . cord-015306-us58wwmp 4425 1 Methods method NNS cord-015306-us58wwmp 4425 2 : : : cord-015306-us58wwmp 4425 3 In in IN cord-015306-us58wwmp 4425 4 a a DT cord-015306-us58wwmp 4425 5 cross cross JJ cord-015306-us58wwmp 4425 6 - - JJ cord-015306-us58wwmp 4425 7 sectional sectional JJ cord-015306-us58wwmp 4425 8 approach approach NN cord-015306-us58wwmp 4425 9 109 109 CD cord-015306-us58wwmp 4425 10 renal renal JJ cord-015306-us58wwmp 4425 11 transplant transplant NN cord-015306-us58wwmp 4425 12 recipients recipient NNS cord-015306-us58wwmp 4425 13 at at IN cord-015306-us58wwmp 4425 14 three three CD cord-015306-us58wwmp 4425 15 German german JJ cord-015306-us58wwmp 4425 16 transplant transplant NN cord-015306-us58wwmp 4425 17 centres centre NNS cord-015306-us58wwmp 4425 18 were be VBD cord-015306-us58wwmp 4425 19 enrolled enrol VBN cord-015306-us58wwmp 4425 20 . . . cord-015306-us58wwmp 4426 1 We -PRON- PRP cord-015306-us58wwmp 4426 2 measured measure VBD cord-015306-us58wwmp 4426 3 pulse pulse NN cord-015306-us58wwmp 4426 4 wave wave NN cord-015306-us58wwmp 4426 5 velocity velocity NN cord-015306-us58wwmp 4426 6 ( ( -LRB- cord-015306-us58wwmp 4426 7 PWV PWV NNP cord-015306-us58wwmp 4426 8 ) ) -RRB- cord-015306-us58wwmp 4426 9 , , , cord-015306-us58wwmp 4426 10 a a DT cord-015306-us58wwmp 4426 11 strong strong JJ cord-015306-us58wwmp 4426 12 predictor predictor NN cord-015306-us58wwmp 4426 13 for for IN cord-015306-us58wwmp 4426 14 cardiovascular cardiovascular JJ cord-015306-us58wwmp 4426 15 events event NNS cord-015306-us58wwmp 4426 16 , , , cord-015306-us58wwmp 4426 17 as as IN cord-015306-us58wwmp 4426 18 our -PRON- PRP$ cord-015306-us58wwmp 4426 19 primary primary JJ cord-015306-us58wwmp 4426 20 end end NN cord-015306-us58wwmp 4426 21 point point NN cord-015306-us58wwmp 4426 22 . . . cord-015306-us58wwmp 4427 1 In in IN cord-015306-us58wwmp 4427 2 all all DT cord-015306-us58wwmp 4427 3 participants participant NNS cord-015306-us58wwmp 4427 4 we -PRON- PRP cord-015306-us58wwmp 4427 5 assessed assess VBD cord-015306-us58wwmp 4427 6 classical classical JJ cord-015306-us58wwmp 4427 7 ( ( -LRB- cord-015306-us58wwmp 4427 8 e.g. e.g. IN cord-015306-us58wwmp 4427 9 blood blood NN cord-015306-us58wwmp 4427 10 pressure pressure NN cord-015306-us58wwmp 4427 11 , , , cord-015306-us58wwmp 4427 12 cholesterol cholesterol NN cord-015306-us58wwmp 4427 13 ) ) -RRB- cord-015306-us58wwmp 4427 14 and and CC cord-015306-us58wwmp 4427 15 non non JJ cord-015306-us58wwmp 4427 16 - - JJ cord-015306-us58wwmp 4427 17 classical classical JJ cord-015306-us58wwmp 4427 18 ( ( -LRB- cord-015306-us58wwmp 4427 19 e.g. e.g. RB cord-015306-us58wwmp 4427 20 CRP CRP NNP cord-015306-us58wwmp 4427 21 , , , cord-015306-us58wwmp 4427 22 PTH PTH NNP cord-015306-us58wwmp 4427 23 ) ) -RRB- cord-015306-us58wwmp 4427 24 cardiovascular cardiovascular JJ cord-015306-us58wwmp 4427 25 risk risk NN cord-015306-us58wwmp 4427 26 parameters parameter NNS cord-015306-us58wwmp 4427 27 . . . cord-015306-us58wwmp 4428 1 Results result NNS cord-015306-us58wwmp 4428 2 : : : cord-015306-us58wwmp 4429 1 Patients patient NNS cord-015306-us58wwmp 4429 2 were be VBD cord-015306-us58wwmp 4429 3 13 13 CD cord-015306-us58wwmp 4429 4 ± ± CD cord-015306-us58wwmp 4429 5 3 3 CD cord-015306-us58wwmp 4429 6 years year NNS cord-015306-us58wwmp 4429 7 of of IN cord-015306-us58wwmp 4429 8 age age NN cord-015306-us58wwmp 4429 9 and and CC cord-015306-us58wwmp 4429 10 had have VBD cord-015306-us58wwmp 4429 11 received receive VBN cord-015306-us58wwmp 4429 12 their -PRON- PRP$ cord-015306-us58wwmp 4429 13 transplant transplant NN cord-015306-us58wwmp 4429 14 5 5 CD cord-015306-us58wwmp 4429 15 ± ± CD cord-015306-us58wwmp 4429 16 4 4 CD cord-015306-us58wwmp 4429 17 years year NNS cord-015306-us58wwmp 4429 18 ago ago RB cord-015306-us58wwmp 4429 19 . . . cord-015306-us58wwmp 4430 1 PWV PWV NNP cord-015306-us58wwmp 4430 2 - - HYPH cord-015306-us58wwmp 4430 3 SDS SDS NNP cord-015306-us58wwmp 4430 4 adjusted adjust VBD cord-015306-us58wwmp 4430 5 to to IN cord-015306-us58wwmp 4430 6 height height NN cord-015306-us58wwmp 4430 7 was be VBD cord-015306-us58wwmp 4430 8 0.4 0.4 CD cord-015306-us58wwmp 4430 9 ± ± CD cord-015306-us58wwmp 4430 10 1.5 1.5 CD cord-015306-us58wwmp 4430 11 . . . cord-015306-us58wwmp 4431 1 In in IN cord-015306-us58wwmp 4431 2 order order NN cord-015306-us58wwmp 4431 3 to to TO cord-015306-us58wwmp 4431 4 identify identify VB cord-015306-us58wwmp 4431 5 predictors predictor NNS cord-015306-us58wwmp 4431 6 of of IN cord-015306-us58wwmp 4431 7 elevated elevate VBN cord-015306-us58wwmp 4431 8 PWV PWV NNP cord-015306-us58wwmp 4431 9 , , , cord-015306-us58wwmp 4431 10 we -PRON- PRP cord-015306-us58wwmp 4431 11 performed perform VBD cord-015306-us58wwmp 4431 12 a a DT cord-015306-us58wwmp 4431 13 univariate univariate JJ cord-015306-us58wwmp 4431 14 screen screen NN cord-015306-us58wwmp 4431 15 and and CC cord-015306-us58wwmp 4431 16 introduced introduce VBN cord-015306-us58wwmp 4431 17 factors factor NNS cord-015306-us58wwmp 4431 18 with with IN cord-015306-us58wwmp 4431 19 a a DT cord-015306-us58wwmp 4431 20 p p NN cord-015306-us58wwmp 4431 21 - - HYPH cord-015306-us58wwmp 4431 22 value value NN cord-015306-us58wwmp 4431 23 below below IN cord-015306-us58wwmp 4431 24 0.2 0.2 CD cord-015306-us58wwmp 4431 25 into into IN cord-015306-us58wwmp 4431 26 a a DT cord-015306-us58wwmp 4431 27 stepwise stepwise JJ cord-015306-us58wwmp 4431 28 forward forward RB cord-015306-us58wwmp 4431 29 linear linear JJ cord-015306-us58wwmp 4431 30 regression regression NN cord-015306-us58wwmp 4431 31 analysis analysis NN cord-015306-us58wwmp 4431 32 . . . cord-015306-us58wwmp 4432 1 We -PRON- PRP cord-015306-us58wwmp 4432 2 found find VBD cord-015306-us58wwmp 4432 3 that that IN cord-015306-us58wwmp 4432 4 systolic systolic JJ cord-015306-us58wwmp 4432 5 blood blood NN cord-015306-us58wwmp 4432 6 pressure pressure NN cord-015306-us58wwmp 4432 7 in in IN cord-015306-us58wwmp 4432 8 the the DT cord-015306-us58wwmp 4432 9 ambulatory ambulatory JJ cord-015306-us58wwmp 4432 10 blood blood NN cord-015306-us58wwmp 4432 11 pressure pressure NN cord-015306-us58wwmp 4432 12 measurement measurement NN cord-015306-us58wwmp 4432 13 and and CC cord-015306-us58wwmp 4432 14 GFR GFR NNP cord-015306-us58wwmp 4432 15 independently independently RB cord-015306-us58wwmp 4432 16 predicted predict VBD cord-015306-us58wwmp 4432 17 PWV PWV NNP cord-015306-us58wwmp 4432 18 - - HYPH cord-015306-us58wwmp 4432 19 SDS SDS NNP cord-015306-us58wwmp 4432 20 ( ( -LRB- cord-015306-us58wwmp 4432 21 table table NN cord-015306-us58wwmp 4432 22 ) ) -RRB- cord-015306-us58wwmp 4432 23 . . . cord-015306-us58wwmp 4433 1 Conclusion conclusion NN cord-015306-us58wwmp 4433 2 : : : cord-015306-us58wwmp 4434 1 Our -PRON- PRP$ cord-015306-us58wwmp 4434 2 results result NNS cord-015306-us58wwmp 4434 3 show show VBP cord-015306-us58wwmp 4434 4 a a DT cord-015306-us58wwmp 4434 5 large large JJ cord-015306-us58wwmp 4434 6 variability variability NN cord-015306-us58wwmp 4434 7 in in IN cord-015306-us58wwmp 4434 8 aortic aortic JJ cord-015306-us58wwmp 4434 9 stiffness stiffness NN cord-015306-us58wwmp 4434 10 in in IN cord-015306-us58wwmp 4434 11 children child NNS cord-015306-us58wwmp 4434 12 after after IN cord-015306-us58wwmp 4434 13 renal renal JJ cord-015306-us58wwmp 4434 14 transplantation transplantation NN cord-015306-us58wwmp 4434 15 . . . cord-015306-us58wwmp 4435 1 We -PRON- PRP cord-015306-us58wwmp 4435 2 found find VBD cord-015306-us58wwmp 4435 3 elevated elevate VBN cord-015306-us58wwmp 4435 4 PWV PWV NNP cord-015306-us58wwmp 4435 5 to to TO cord-015306-us58wwmp 4435 6 be be VB cord-015306-us58wwmp 4435 7 associated associate VBN cord-015306-us58wwmp 4435 8 with with IN cord-015306-us58wwmp 4435 9 classical classical JJ cord-015306-us58wwmp 4435 10 as as RB cord-015306-us58wwmp 4435 11 well well RB cord-015306-us58wwmp 4435 12 as as IN cord-015306-us58wwmp 4435 13 non non JJ cord-015306-us58wwmp 4435 14 - - JJ cord-015306-us58wwmp 4435 15 classical classical JJ cord-015306-us58wwmp 4435 16 risk risk NN cord-015306-us58wwmp 4435 17 factors factor NNS cord-015306-us58wwmp 4435 18 . . . cord-015306-us58wwmp 4436 1 The the DT cord-015306-us58wwmp 4436 2 wide wide JJ cord-015306-us58wwmp 4436 3 range range NN cord-015306-us58wwmp 4436 4 of of IN cord-015306-us58wwmp 4436 5 cardiovascular cardiovascular JJ cord-015306-us58wwmp 4436 6 comorbidity comorbidity NN cord-015306-us58wwmp 4436 7 seen see VBN cord-015306-us58wwmp 4436 8 in in IN cord-015306-us58wwmp 4436 9 these these DT cord-015306-us58wwmp 4436 10 patients patient NNS cord-015306-us58wwmp 4436 11 highlights highlight VBZ cord-015306-us58wwmp 4436 12 the the DT cord-015306-us58wwmp 4436 13 need need NN cord-015306-us58wwmp 4436 14 for for IN cord-015306-us58wwmp 4436 15 individualized individualized JJ cord-015306-us58wwmp 4436 16 risk risk NN cord-015306-us58wwmp 4436 17 factor factor NN cord-015306-us58wwmp 4436 18 monitoring monitoring NN cord-015306-us58wwmp 4436 19 and and CC cord-015306-us58wwmp 4436 20 management management NN cord-015306-us58wwmp 4436 21 . . . cord-015306-us58wwmp 4437 1 Objective objective JJ cord-015306-us58wwmp 4437 2 : : : cord-015306-us58wwmp 4437 3 Renal renal JJ cord-015306-us58wwmp 4437 4 transplantation transplantation NN cord-015306-us58wwmp 4437 5 is be VBZ cord-015306-us58wwmp 4437 6 the the DT cord-015306-us58wwmp 4437 7 optimal optimal JJ cord-015306-us58wwmp 4437 8 treatment treatment NN cord-015306-us58wwmp 4437 9 for for IN cord-015306-us58wwmp 4437 10 end end NN cord-015306-us58wwmp 4437 11 - - HYPH cord-015306-us58wwmp 4437 12 stage stage NN cord-015306-us58wwmp 4437 13 renal renal JJ cord-015306-us58wwmp 4437 14 disease disease NN cord-015306-us58wwmp 4437 15 in in IN cord-015306-us58wwmp 4437 16 children child NNS cord-015306-us58wwmp 4437 17 , , , cord-015306-us58wwmp 4437 18 . . . cord-015306-us58wwmp 4438 1 However however RB cord-015306-us58wwmp 4438 2 , , , cord-015306-us58wwmp 4438 3 it -PRON- PRP cord-015306-us58wwmp 4438 4 remains remain VBZ cord-015306-us58wwmp 4438 5 technically technically RB cord-015306-us58wwmp 4438 6 challenging challenging JJ cord-015306-us58wwmp 4438 7 in in IN cord-015306-us58wwmp 4438 8 small small JJ cord-015306-us58wwmp 4438 9 recipients recipient NNS cord-015306-us58wwmp 4438 10 , , , cord-015306-us58wwmp 4438 11 especially especially RB cord-015306-us58wwmp 4438 12 with with IN cord-015306-us58wwmp 4438 13 adult adult NN cord-015306-us58wwmp 4438 14 - - HYPH cord-015306-us58wwmp 4438 15 sized sized JJ cord-015306-us58wwmp 4438 16 graft graft NN cord-015306-us58wwmp 4438 17 . . . cord-015306-us58wwmp 4439 1 We -PRON- PRP cord-015306-us58wwmp 4439 2 report report VBP cord-015306-us58wwmp 4439 3 on on IN cord-015306-us58wwmp 4439 4 two two CD cord-015306-us58wwmp 4439 5 4-year 4-year JJ cord-015306-us58wwmp 4439 6 - - HYPH cord-015306-us58wwmp 4439 7 old old JJ cord-015306-us58wwmp 4439 8 children child NNS cord-015306-us58wwmp 4439 9 , , , cord-015306-us58wwmp 4439 10 undergoing undergo VBG cord-015306-us58wwmp 4439 11 living live VBG cord-015306-us58wwmp 4439 12 donor donor NN cord-015306-us58wwmp 4439 13 kidney kidney NN cord-015306-us58wwmp 4439 14 transplantation transplantation NN cord-015306-us58wwmp 4439 15 , , , cord-015306-us58wwmp 4439 16 and and CC cord-015306-us58wwmp 4439 17 describe describe VB cord-015306-us58wwmp 4439 18 our -PRON- PRP$ cord-015306-us58wwmp 4439 19 management management NN cord-015306-us58wwmp 4439 20 after after IN cord-015306-us58wwmp 4439 21 failure failure NN cord-015306-us58wwmp 4439 22 to to TO cord-015306-us58wwmp 4439 23 close close VB cord-015306-us58wwmp 4439 24 the the DT cord-015306-us58wwmp 4439 25 abdominal abdominal JJ cord-015306-us58wwmp 4439 26 wall wall NN cord-015306-us58wwmp 4439 27 . . . cord-015306-us58wwmp 4440 1 Method method NN cord-015306-us58wwmp 4440 2 : : : cord-015306-us58wwmp 4441 1 Both both DT cord-015306-us58wwmp 4441 2 children child NNS cord-015306-us58wwmp 4441 3 weighed weigh VBD cord-015306-us58wwmp 4441 4 < < XX cord-015306-us58wwmp 4441 5 15 15 CD cord-015306-us58wwmp 4441 6 kg kg NNS cord-015306-us58wwmp 4441 7 and and CC cord-015306-us58wwmp 4441 8 received receive VBD cord-015306-us58wwmp 4441 9 their -PRON- PRP$ cord-015306-us58wwmp 4441 10 father father NN cord-015306-us58wwmp 4441 11 's 's POS cord-015306-us58wwmp 4441 12 kidney kidney NN cord-015306-us58wwmp 4441 13 . . . cord-015306-us58wwmp 4442 1 The the DT cord-015306-us58wwmp 4442 2 recipient recipient NN cord-015306-us58wwmp 4442 3 / / SYM cord-015306-us58wwmp 4442 4 donor donor NN cord-015306-us58wwmp 4442 5 weight weight NN cord-015306-us58wwmp 4442 6 ratios ratio NNS cord-015306-us58wwmp 4442 7 were be VBD cord-015306-us58wwmp 4442 8 1/5 1/5 CD cord-015306-us58wwmp 4442 9 and and CC cord-015306-us58wwmp 4442 10 1/6 1/6 DT cord-015306-us58wwmp 4442 11 . . . cord-015306-us58wwmp 4443 1 Surgical surgical JJ cord-015306-us58wwmp 4443 2 procedure procedure NN cord-015306-us58wwmp 4443 3 was be VBD cord-015306-us58wwmp 4443 4 an an DT cord-015306-us58wwmp 4443 5 extra extra JJ cord-015306-us58wwmp 4443 6 peritoneal peritoneal JJ cord-015306-us58wwmp 4443 7 approach approach NN cord-015306-us58wwmp 4443 8 to to IN cord-015306-us58wwmp 4443 9 the the DT cord-015306-us58wwmp 4443 10 iliac iliac JJ cord-015306-us58wwmp 4443 11 fossa fossa NN cord-015306-us58wwmp 4443 12 , , , cord-015306-us58wwmp 4443 13 with with IN cord-015306-us58wwmp 4443 14 vascular vascular JJ cord-015306-us58wwmp 4443 15 anastomosis anastomosis NN cord-015306-us58wwmp 4443 16 on on IN cord-015306-us58wwmp 4443 17 the the DT cord-015306-us58wwmp 4443 18 aorta aorta NNP cord-015306-us58wwmp 4443 19 and and CC cord-015306-us58wwmp 4443 20 vena vena NNP cord-015306-us58wwmp 4443 21 cava cava NNP cord-015306-us58wwmp 4443 22 . . . cord-015306-us58wwmp 4444 1 They -PRON- PRP cord-015306-us58wwmp 4444 2 recieved recieve VBD cord-015306-us58wwmp 4444 3 intensive intensive JJ cord-015306-us58wwmp 4444 4 fluid fluid JJ cord-015306-us58wwmp 4444 5 replacement replacement NN cord-015306-us58wwmp 4444 6 during during IN cord-015306-us58wwmp 4444 7 surgery surgery NN cord-015306-us58wwmp 4444 8 to to TO cord-015306-us58wwmp 4444 9 optimize optimize VB cord-015306-us58wwmp 4444 10 hemodynamic hemodynamic JJ cord-015306-us58wwmp 4444 11 status status NN cord-015306-us58wwmp 4444 12 and and CC cord-015306-us58wwmp 4444 13 graft graft NN cord-015306-us58wwmp 4444 14 perfusion perfusion NN cord-015306-us58wwmp 4444 15 . . . cord-015306-us58wwmp 4445 1 After after IN cord-015306-us58wwmp 4445 2 initial initial JJ cord-015306-us58wwmp 4445 3 successful successful JJ cord-015306-us58wwmp 4445 4 reperfusion reperfusion NN cord-015306-us58wwmp 4445 5 , , , cord-015306-us58wwmp 4445 6 all all DT cord-015306-us58wwmp 4445 7 attempts attempt NNS cord-015306-us58wwmp 4445 8 to to TO cord-015306-us58wwmp 4445 9 close close VB cord-015306-us58wwmp 4445 10 the the DT cord-015306-us58wwmp 4445 11 abdominal abdominal JJ cord-015306-us58wwmp 4445 12 wall wall NN cord-015306-us58wwmp 4445 13 ( ( -LRB- cord-015306-us58wwmp 4445 14 even even RB cord-015306-us58wwmp 4445 15 simple simple JJ cord-015306-us58wwmp 4445 16 skin skin NN cord-015306-us58wwmp 4445 17 closure closure NN cord-015306-us58wwmp 4445 18 or or CC cord-015306-us58wwmp 4445 19 superficial superficial JJ cord-015306-us58wwmp 4445 20 muscle muscle NN cord-015306-us58wwmp 4445 21 layer layer NN cord-015306-us58wwmp 4445 22 closure closure NN cord-015306-us58wwmp 4445 23 ) ) -RRB- cord-015306-us58wwmp 4445 24 led lead VBD cord-015306-us58wwmp 4445 25 to to IN cord-015306-us58wwmp 4445 26 graft graft NN cord-015306-us58wwmp 4445 27 hypoperfusion hypoperfusion NN cord-015306-us58wwmp 4445 28 , , , cord-015306-us58wwmp 4445 29 diagnosed diagnose VBN cord-015306-us58wwmp 4445 30 on on IN cord-015306-us58wwmp 4445 31 graft graft NN cord-015306-us58wwmp 4445 32 colour colour NN cord-015306-us58wwmp 4445 33 change change NN cord-015306-us58wwmp 4445 34 and and CC cord-015306-us58wwmp 4445 35 doppler doppler NN cord-015306-us58wwmp 4445 36 ultrasound ultrasound NN cord-015306-us58wwmp 4445 37 . . . cord-015306-us58wwmp 4446 1 Closure closure NN cord-015306-us58wwmp 4446 2 with with IN cord-015306-us58wwmp 4446 3 resorbableVicryl?mesh resorbablevicryl?mesh NN cord-015306-us58wwmp 4446 4 gave give VBD cord-015306-us58wwmp 4446 5 the the DT cord-015306-us58wwmp 4446 6 same same JJ cord-015306-us58wwmp 4446 7 results result NNS cord-015306-us58wwmp 4446 8 and and CC cord-015306-us58wwmp 4446 9 failure failure NN cord-015306-us58wwmp 4446 10 . . . cord-015306-us58wwmp 4447 1 Finally finally RB cord-015306-us58wwmp 4447 2 , , , cord-015306-us58wwmp 4447 3 we -PRON- PRP cord-015306-us58wwmp 4447 4 had have VBD cord-015306-us58wwmp 4447 5 to to TO cord-015306-us58wwmp 4447 6 close close VB cord-015306-us58wwmp 4447 7 with with IN cord-015306-us58wwmp 4447 8 a a DT cord-015306-us58wwmp 4447 9 synthetic synthetic JJ cord-015306-us58wwmp 4447 10 non non AFX cord-015306-us58wwmp 4447 11 resorbable resorbable JJ cord-015306-us58wwmp 4447 12 plate plate NN cord-015306-us58wwmp 4447 13 ( ( -LRB- cord-015306-us58wwmp 4447 14 Goretex Goretex NNP cord-015306-us58wwmp 4447 15 ? ? . cord-015306-us58wwmp 4447 16 ) ) -RRB- cord-015306-us58wwmp 4447 17 , , , cord-015306-us58wwmp 4447 18 without without IN cord-015306-us58wwmp 4447 19 skin skin NN cord-015306-us58wwmp 4447 20 closure closure NN cord-015306-us58wwmp 4447 21 . . . cord-015306-us58wwmp 4448 1 Results result NNS cord-015306-us58wwmp 4448 2 : : : cord-015306-us58wwmp 4449 1 The the DT cord-015306-us58wwmp 4449 2 first first JJ cord-015306-us58wwmp 4449 3 patient patient NN cord-015306-us58wwmp 4449 4 presented present VBD cord-015306-us58wwmp 4449 5 acute acute JJ cord-015306-us58wwmp 4449 6 tubular tubular JJ cord-015306-us58wwmp 4449 7 necrosis necrosis NN cord-015306-us58wwmp 4449 8 and and CC cord-015306-us58wwmp 4449 9 required require VBD cord-015306-us58wwmp 4449 10 continuous continuous JJ cord-015306-us58wwmp 4449 11 hemofiltration hemofiltration NN cord-015306-us58wwmp 4449 12 from from IN cord-015306-us58wwmp 4449 13 day day NN cord-015306-us58wwmp 4449 14 2 2 CD cord-015306-us58wwmp 4449 15 to to IN cord-015306-us58wwmp 4449 16 6 6 CD cord-015306-us58wwmp 4449 17 . . . cord-015306-us58wwmp 4450 1 The the DT cord-015306-us58wwmp 4450 2 second second JJ cord-015306-us58wwmp 4450 3 one one NN cord-015306-us58wwmp 4450 4 had have VBD cord-015306-us58wwmp 4450 5 immediate immediate JJ cord-015306-us58wwmp 4450 6 diuresis diuresis NN cord-015306-us58wwmp 4450 7 and and CC cord-015306-us58wwmp 4450 8 with with IN cord-015306-us58wwmp 4450 9 a a DT cord-015306-us58wwmp 4450 10 decrease decrease NN cord-015306-us58wwmp 4450 11 of of IN cord-015306-us58wwmp 4450 12 serum serum NN cord-015306-us58wwmp 4450 13 creatinine creatinine NN cord-015306-us58wwmp 4450 14 to to IN cord-015306-us58wwmp 4450 15 65μmol 65μmol CD cord-015306-us58wwmp 4450 16 / / SYM cord-015306-us58wwmp 4450 17 l l NN cord-015306-us58wwmp 4450 18 at at IN cord-015306-us58wwmp 4450 19 day day NN cord-015306-us58wwmp 4450 20 2 2 CD cord-015306-us58wwmp 4450 21 . . . cord-015306-us58wwmp 4451 1 In in IN cord-015306-us58wwmp 4451 2 both both DT cord-015306-us58wwmp 4451 3 cases case NNS cord-015306-us58wwmp 4451 4 , , , cord-015306-us58wwmp 4451 5 kidney kidney NN cord-015306-us58wwmp 4451 6 was be VBD cord-015306-us58wwmp 4451 7 successfully successfully RB cord-015306-us58wwmp 4451 8 replaced replace VBN cord-015306-us58wwmp 4451 9 intra intra JJ cord-015306-us58wwmp 4451 10 abdominally abdominally RB cord-015306-us58wwmp 4451 11 at at IN cord-015306-us58wwmp 4451 12 day day NN cord-015306-us58wwmp 4451 13 6 6 CD cord-015306-us58wwmp 4451 14 , , , cord-015306-us58wwmp 4451 15 with with IN cord-015306-us58wwmp 4451 16 superficial superficial JJ cord-015306-us58wwmp 4451 17 closure closure NN cord-015306-us58wwmp 4451 18 of of IN cord-015306-us58wwmp 4451 19 facia facia NN cord-015306-us58wwmp 4451 20 and and CC cord-015306-us58wwmp 4451 21 skin skin NN cord-015306-us58wwmp 4451 22 in in IN cord-015306-us58wwmp 4451 23 one one CD cord-015306-us58wwmp 4451 24 child child NN cord-015306-us58wwmp 4451 25 and and CC cord-015306-us58wwmp 4451 26 with with IN cord-015306-us58wwmp 4451 27 Vicryl Vicryl NNP cord-015306-us58wwmp 4451 28 ? ? . cord-015306-us58wwmp 4452 1 mesh mesh NN cord-015306-us58wwmp 4452 2 and and CC cord-015306-us58wwmp 4452 3 skin skin NN cord-015306-us58wwmp 4452 4 in in IN cord-015306-us58wwmp 4452 5 the the DT cord-015306-us58wwmp 4452 6 second second JJ cord-015306-us58wwmp 4452 7 one one NN cord-015306-us58wwmp 4452 8 . . . cord-015306-us58wwmp 4453 1 No no DT cord-015306-us58wwmp 4453 2 effect effect NN cord-015306-us58wwmp 4453 3 on on IN cord-015306-us58wwmp 4453 4 clinical clinical JJ cord-015306-us58wwmp 4453 5 graft graft NN cord-015306-us58wwmp 4453 6 perfusion perfusion NN cord-015306-us58wwmp 4453 7 or or CC cord-015306-us58wwmp 4453 8 Doppler doppler NN cord-015306-us58wwmp 4453 9 parameters parameter NNS cord-015306-us58wwmp 4453 10 were be VBD cord-015306-us58wwmp 4453 11 observed observe VBN cord-015306-us58wwmp 4453 12 after after IN cord-015306-us58wwmp 4453 13 final final JJ cord-015306-us58wwmp 4453 14 closure closure NN cord-015306-us58wwmp 4453 15 . . . cord-015306-us58wwmp 4454 1 In in IN cord-015306-us58wwmp 4454 2 patient patient JJ cord-015306-us58wwmp 4454 3 2 2 CD cord-015306-us58wwmp 4454 4 , , , cord-015306-us58wwmp 4454 5 a a DT cord-015306-us58wwmp 4454 6 limited limited JJ cord-015306-us58wwmp 4454 7 necrotic necrotic JJ cord-015306-us58wwmp 4454 8 area area NN cord-015306-us58wwmp 4454 9 3x3 3x3 CD cord-015306-us58wwmp 4454 10 cm cm NNS cord-015306-us58wwmp 4454 11 , , , cord-015306-us58wwmp 4454 12 on on IN cord-015306-us58wwmp 4454 13 direct direct JJ cord-015306-us58wwmp 4454 14 contact contact NN cord-015306-us58wwmp 4454 15 with with IN cord-015306-us58wwmp 4454 16 the the DT cord-015306-us58wwmp 4454 17 Goretex?plate goretex?plate NN cord-015306-us58wwmp 4454 18 , , , cord-015306-us58wwmp 4454 19 was be VBD cord-015306-us58wwmp 4454 20 noticed notice VBN cord-015306-us58wwmp 4454 21 during during IN cord-015306-us58wwmp 4454 22 the the DT cord-015306-us58wwmp 4454 23 second second JJ cord-015306-us58wwmp 4454 24 surgery surgery NN cord-015306-us58wwmp 4454 25 procedure procedure NN cord-015306-us58wwmp 4454 26 but but CC cord-015306-us58wwmp 4454 27 it -PRON- PRP cord-015306-us58wwmp 4454 28 remained remain VBD cord-015306-us58wwmp 4454 29 very very RB cord-015306-us58wwmp 4454 30 superficial superficial JJ cord-015306-us58wwmp 4454 31 . . . cord-015306-us58wwmp 4455 1 Finally finally RB cord-015306-us58wwmp 4455 2 , , , cord-015306-us58wwmp 4455 3 with with IN cord-015306-us58wwmp 4455 4 a a DT cord-015306-us58wwmp 4455 5 follow follow NN cord-015306-us58wwmp 4455 6 - - HYPH cord-015306-us58wwmp 4455 7 up up NN cord-015306-us58wwmp 4455 8 of of IN cord-015306-us58wwmp 4455 9 respectively respectively RB cord-015306-us58wwmp 4455 10 1 1 CD cord-015306-us58wwmp 4455 11 year year NN cord-015306-us58wwmp 4455 12 and and CC cord-015306-us58wwmp 4455 13 1 1 CD cord-015306-us58wwmp 4455 14 month month NN cord-015306-us58wwmp 4455 15 , , , cord-015306-us58wwmp 4455 16 recipients recipient NNS cord-015306-us58wwmp 4455 17 and and CC cord-015306-us58wwmp 4455 18 grafts graft NNS cord-015306-us58wwmp 4455 19 are be VBP cord-015306-us58wwmp 4455 20 doing do VBG cord-015306-us58wwmp 4455 21 well well RB cord-015306-us58wwmp 4455 22 without without IN cord-015306-us58wwmp 4455 23 any any DT cord-015306-us58wwmp 4455 24 other other JJ cord-015306-us58wwmp 4455 25 events event NNS cord-015306-us58wwmp 4455 26 and and CC cord-015306-us58wwmp 4455 27 a a DT cord-015306-us58wwmp 4455 28 serum serum NN cord-015306-us58wwmp 4455 29 creatinine creatinine NN cord-015306-us58wwmp 4455 30 of of IN cord-015306-us58wwmp 4455 31 40 40 CD cord-015306-us58wwmp 4455 32 - - SYM cord-015306-us58wwmp 4455 33 50 50 CD cord-015306-us58wwmp 4455 34 μmol μmol NNP cord-015306-us58wwmp 4455 35 / / SYM cord-015306-us58wwmp 4455 36 l l NN cord-015306-us58wwmp 4455 37 . . . cord-015306-us58wwmp 4456 1 Conclusion conclusion NN cord-015306-us58wwmp 4456 2 : : : cord-015306-us58wwmp 4457 1 In in IN cord-015306-us58wwmp 4457 2 conclusion conclusion NN cord-015306-us58wwmp 4457 3 , , , cord-015306-us58wwmp 4457 4 in in IN cord-015306-us58wwmp 4457 5 small small JJ cord-015306-us58wwmp 4457 6 patients patient NNS cord-015306-us58wwmp 4457 7 kidney kidney NN cord-015306-us58wwmp 4457 8 size size NN cord-015306-us58wwmp 4457 9 discrepancy discrepancy NN cord-015306-us58wwmp 4457 10 and and CC cord-015306-us58wwmp 4457 11 tissue tissue NN cord-015306-us58wwmp 4457 12 oedema oedema NN cord-015306-us58wwmp 4457 13 can can MD cord-015306-us58wwmp 4457 14 lead lead VB cord-015306-us58wwmp 4457 15 to to IN cord-015306-us58wwmp 4457 16 renal renal JJ cord-015306-us58wwmp 4457 17 allograft allograft NN cord-015306-us58wwmp 4457 18 compartment compartment NN cord-015306-us58wwmp 4457 19 syndrome syndrome NN cord-015306-us58wwmp 4457 20 . . . cord-015306-us58wwmp 4458 1 In in IN cord-015306-us58wwmp 4458 2 this this DT cord-015306-us58wwmp 4458 3 situation situation NN cord-015306-us58wwmp 4458 4 , , , cord-015306-us58wwmp 4458 5 Goretex Goretex NNP cord-015306-us58wwmp 4458 6 ? ? . cord-015306-us58wwmp 4458 7 plate plate NN cord-015306-us58wwmp 4458 8 is be VBZ cord-015306-us58wwmp 4458 9 an an DT cord-015306-us58wwmp 4458 10 option option NN cord-015306-us58wwmp 4458 11 for for IN cord-015306-us58wwmp 4458 12 initial initial JJ cord-015306-us58wwmp 4458 13 wound wound NN cord-015306-us58wwmp 4458 14 closure closure NN cord-015306-us58wwmp 4458 15 and and CC cord-015306-us58wwmp 4458 16 graft graft NN cord-015306-us58wwmp 4458 17 salvaging salvaging NN cord-015306-us58wwmp 4458 18 . . . cord-015306-us58wwmp 4459 1 Objective objective JJ cord-015306-us58wwmp 4460 1 : : : cord-015306-us58wwmp 4460 2 AMR AMR NNP cord-015306-us58wwmp 4460 3 in in IN cord-015306-us58wwmp 4460 4 the the DT cord-015306-us58wwmp 4460 5 transplant transplant NN cord-015306-us58wwmp 4460 6 is be VBZ cord-015306-us58wwmp 4460 7 one one CD cord-015306-us58wwmp 4460 8 of of IN cord-015306-us58wwmp 4460 9 the the DT cord-015306-us58wwmp 4460 10 most most RBS cord-015306-us58wwmp 4460 11 complicated complicated JJ cord-015306-us58wwmp 4460 12 form form NN cord-015306-us58wwmp 4460 13 of of IN cord-015306-us58wwmp 4460 14 rejection rejection NN cord-015306-us58wwmp 4460 15 , , , cord-015306-us58wwmp 4460 16 which which WDT cord-015306-us58wwmp 4460 17 do do VBP cord-015306-us58wwmp 4460 18 not not RB cord-015306-us58wwmp 4460 19 respond respond VB cord-015306-us58wwmp 4460 20 to to IN cord-015306-us58wwmp 4460 21 the the DT cord-015306-us58wwmp 4460 22 standard standard JJ cord-015306-us58wwmp 4460 23 therapy therapy NN cord-015306-us58wwmp 4460 24 . . . cord-015306-us58wwmp 4461 1 Survival survival NN cord-015306-us58wwmp 4461 2 of of IN cord-015306-us58wwmp 4461 3 the the DT cord-015306-us58wwmp 4461 4 transplant transplant NN cord-015306-us58wwmp 4461 5 exposed expose VBN cord-015306-us58wwmp 4461 6 to to IN cord-015306-us58wwmp 4461 7 AMR AMR NNP cord-015306-us58wwmp 4461 8 is be VBZ cord-015306-us58wwmp 4461 9 still still RB cord-015306-us58wwmp 4461 10 low low JJ cord-015306-us58wwmp 4461 11 . . . cord-015306-us58wwmp 4462 1 This this DT cord-015306-us58wwmp 4462 2 is be VBZ cord-015306-us58wwmp 4462 3 a a DT cord-015306-us58wwmp 4462 4 clinical clinical JJ cord-015306-us58wwmp 4462 5 report report NN cord-015306-us58wwmp 4462 6 of of IN cord-015306-us58wwmp 4462 7 an an DT cord-015306-us58wwmp 4462 8 AMR AMR NNP cord-015306-us58wwmp 4462 9 - - HYPH cord-015306-us58wwmp 4462 10 treatment treatment NN cord-015306-us58wwmp 4462 11 in in IN cord-015306-us58wwmp 4462 12 children child NNS cord-015306-us58wwmp 4462 13 in in IN cord-015306-us58wwmp 4462 14 our -PRON- PRP$ cord-015306-us58wwmp 4462 15 centre centre NN cord-015306-us58wwmp 4462 16 . . . cord-015306-us58wwmp 4463 1 Methods method NNS cord-015306-us58wwmp 4463 2 : : : cord-015306-us58wwmp 4463 3 4 4 CD cord-015306-us58wwmp 4463 4 girls girl NNS cord-015306-us58wwmp 4463 5 with with IN cord-015306-us58wwmp 4463 6 AMR AMR NNP cord-015306-us58wwmp 4463 7 after after IN cord-015306-us58wwmp 4463 8 the the DT cord-015306-us58wwmp 4463 9 deceased deceased JJ cord-015306-us58wwmp 4463 10 donor donor NN cord-015306-us58wwmp 4463 11 renal renal JJ cord-015306-us58wwmp 4463 12 transplantation transplantation NN cord-015306-us58wwmp 4463 13 were be VBD cord-015306-us58wwmp 4463 14 observed observe VBN cord-015306-us58wwmp 4463 15 of of IN cord-015306-us58wwmp 4463 16 age10 age10 CD cord-015306-us58wwmp 4463 17 , , , cord-015306-us58wwmp 4463 18 13 13 CD cord-015306-us58wwmp 4463 19 , , , cord-015306-us58wwmp 4463 20 15 15 CD cord-015306-us58wwmp 4463 21 , , , cord-015306-us58wwmp 4463 22 16 16 CD cord-015306-us58wwmp 4463 23 from from IN cord-015306-us58wwmp 4463 24 2009 2009 CD cord-015306-us58wwmp 4463 25 to to IN cord-015306-us58wwmp 4463 26 2012 2012 CD cord-015306-us58wwmp 4463 27 in in IN cord-015306-us58wwmp 4463 28 our -PRON- PRP$ cord-015306-us58wwmp 4463 29 centre centre NN cord-015306-us58wwmp 4463 30 . . . cord-015306-us58wwmp 4464 1 All all DT cord-015306-us58wwmp 4464 2 had have VBD cord-015306-us58wwmp 4464 3 a a DT cord-015306-us58wwmp 4464 4 negative negative JJ cord-015306-us58wwmp 4464 5 " " `` cord-015306-us58wwmp 4464 6 cross cross JJ cord-015306-us58wwmp 4464 7 - - JJ cord-015306-us58wwmp 4464 8 match match NN cord-015306-us58wwmp 4464 9 " " '' cord-015306-us58wwmp 4464 10 at at IN cord-015306-us58wwmp 4464 11 the the DT cord-015306-us58wwmp 4464 12 time time NN cord-015306-us58wwmp 4464 13 of of IN cord-015306-us58wwmp 4464 14 transplantation transplantation NN cord-015306-us58wwmp 4464 15 , , , cord-015306-us58wwmp 4464 16 the the DT cord-015306-us58wwmp 4464 17 quantity quantity NN cord-015306-us58wwmp 4464 18 of of IN cord-015306-us58wwmp 4464 19 discordant discordant JJ cord-015306-us58wwmp 4464 20 antigens antigen NNS cord-015306-us58wwmp 4464 21 varied vary VBN cord-015306-us58wwmp 4464 22 from from IN cord-015306-us58wwmp 4464 23 3 3 CD cord-015306-us58wwmp 4464 24 to to IN cord-015306-us58wwmp 4464 25 6 6 CD cord-015306-us58wwmp 4464 26 . . . cord-015306-us58wwmp 4465 1 For for IN cord-015306-us58wwmp 4465 2 1 1 CD cord-015306-us58wwmp 4465 3 girl girl NN cord-015306-us58wwmp 4465 4 it -PRON- PRP cord-015306-us58wwmp 4465 5 was be VBD cord-015306-us58wwmp 4465 6 the the DT cord-015306-us58wwmp 4465 7 2 2 CD cord-015306-us58wwmp 4465 8 transplantation transplantation NN cord-015306-us58wwmp 4465 9 . . . cord-015306-us58wwmp 4466 1 3 3 CD cord-015306-us58wwmp 4466 2 children child NNS cord-015306-us58wwmp 4466 3 had have VBD cord-015306-us58wwmp 4466 4 an an DT cord-015306-us58wwmp 4466 5 immediate immediate JJ cord-015306-us58wwmp 4466 6 function function NN cord-015306-us58wwmp 4466 7 of of IN cord-015306-us58wwmp 4466 8 the the DT cord-015306-us58wwmp 4466 9 graft,1-delayed graft,1-delayed NNP cord-015306-us58wwmp 4466 10 . . . cord-015306-us58wwmp 4467 1 Induction induction NN cord-015306-us58wwmp 4467 2 of of IN cord-015306-us58wwmp 4467 3 the the DT cord-015306-us58wwmp 4467 4 immunosuppressive immunosuppressive JJ cord-015306-us58wwmp 4467 5 therapy therapy NN cord-015306-us58wwmp 4467 6 : : : cord-015306-us58wwmp 4467 7 polyclonal polyclonal JJ cord-015306-us58wwmp 4467 8 antibodies antibody NNS cord-015306-us58wwmp 4467 9 and and CC cord-015306-us58wwmp 4467 10 methylprednisolone methylprednisolone NN cord-015306-us58wwmp 4467 11 , , , cord-015306-us58wwmp 4467 12 maintenance maintenance NN cord-015306-us58wwmp 4467 13 : : : cord-015306-us58wwmp 4467 14 tacrolimus tacrolimus NNP cord-015306-us58wwmp 4467 15 , , , cord-015306-us58wwmp 4467 16 prednisolone prednisolone NN cord-015306-us58wwmp 4467 17 , , , cord-015306-us58wwmp 4467 18 MMF MMF NNP cord-015306-us58wwmp 4467 19 . . . cord-015306-us58wwmp 4468 1 2 2 CD cord-015306-us58wwmp 4468 2 children child NNS cord-015306-us58wwmp 4468 3 had have VBD cord-015306-us58wwmp 4468 4 high high JJ cord-015306-us58wwmp 4468 5 level level NN cord-015306-us58wwmp 4468 6 of of IN cord-015306-us58wwmp 4468 7 preexisting preexist VBG cord-015306-us58wwmp 4468 8 antibodies antibody NNS cord-015306-us58wwmp 4468 9 ( ( -LRB- cord-015306-us58wwmp 4468 10 more more JJR cord-015306-us58wwmp 4468 11 than than IN cord-015306-us58wwmp 4468 12 30 30 CD cord-015306-us58wwmp 4468 13 % % NN cord-015306-us58wwmp 4468 14 ) ) -RRB- cord-015306-us58wwmp 4468 15 at at IN cord-015306-us58wwmp 4468 16 the the DT cord-015306-us58wwmp 4468 17 time time NN cord-015306-us58wwmp 4468 18 of of IN cord-015306-us58wwmp 4468 19 transplantation transplantation NN cord-015306-us58wwmp 4468 20 . . . cord-015306-us58wwmp 4469 1 There there EX cord-015306-us58wwmp 4469 2 were be VBD cord-015306-us58wwmp 4469 3 morphological morphological JJ cord-015306-us58wwmp 4469 4 confirmation confirmation NN cord-015306-us58wwmp 4469 5 and and CC cord-015306-us58wwmp 4469 6 decrease decrease NN cord-015306-us58wwmp 4469 7 of of IN cord-015306-us58wwmp 4469 8 the the DT cord-015306-us58wwmp 4469 9 graft graft NN cord-015306-us58wwmp 4469 10 function function NN cord-015306-us58wwmp 4469 11 for for IN cord-015306-us58wwmp 4469 12 the the DT cord-015306-us58wwmp 4469 13 moment moment NN cord-015306-us58wwmp 4469 14 of of IN cord-015306-us58wwmp 4469 15 AMR AMR NNP cord-015306-us58wwmp 4469 16 . . . cord-015306-us58wwmp 4470 1 The the DT cord-015306-us58wwmp 4470 2 treatment treatment NN cord-015306-us58wwmp 4470 3 of of IN cord-015306-us58wwmp 4470 4 AMR AMR NNP cord-015306-us58wwmp 4470 5 included include VBD cord-015306-us58wwmp 4470 6 : : : cord-015306-us58wwmp 4470 7 pulse pulse NN cord-015306-us58wwmp 4470 8 therapy therapy NN cord-015306-us58wwmp 4470 9 of of IN cord-015306-us58wwmp 4470 10 methylprednisolone methylprednisolone NNP cord-015306-us58wwmp 4470 11 , , , cord-015306-us58wwmp 4470 12 polyclonal polyclonal JJ cord-015306-us58wwmp 4470 13 antibodies antibody NNS cord-015306-us58wwmp 4470 14 , , , cord-015306-us58wwmp 4470 15 rituximab rituximab NN cord-015306-us58wwmp 4470 16 , , , cord-015306-us58wwmp 4470 17 immunoglobulin immunoglobulin NN cord-015306-us58wwmp 4470 18 iv iv NNP cord-015306-us58wwmp 4470 19 . . . cord-015306-us58wwmp 4471 1 Function function NN cord-015306-us58wwmp 4471 2 of of IN cord-015306-us58wwmp 4471 3 the the DT cord-015306-us58wwmp 4471 4 graft graft NN cord-015306-us58wwmp 4471 5 was be VBD cord-015306-us58wwmp 4471 6 evaluated evaluate VBN cord-015306-us58wwmp 4471 7 by by IN cord-015306-us58wwmp 4471 8 the the DT cord-015306-us58wwmp 4471 9 Cr Cr NNP cord-015306-us58wwmp 4471 10 levels level NNS cord-015306-us58wwmp 4471 11 , , , cord-015306-us58wwmp 4471 12 GFR GFR NNP cord-015306-us58wwmp 4471 13 , , , cord-015306-us58wwmp 4471 14 the the DT cord-015306-us58wwmp 4471 15 level level NN cord-015306-us58wwmp 4471 16 of of IN cord-015306-us58wwmp 4471 17 DSA.Results dsa.results NN cord-015306-us58wwmp 4471 18 : : : cord-015306-us58wwmp 4471 19 The the DT cord-015306-us58wwmp 4471 20 Cr Cr NNP cord-015306-us58wwmp 4471 21 of of IN cord-015306-us58wwmp 4471 22 children child NNS cord-015306-us58wwmp 4471 23 was be VBD cord-015306-us58wwmp 4471 24 483±256 483±256 CD cord-015306-us58wwmp 4471 25 umol umol NNP cord-015306-us58wwmp 4471 26 / / SYM cord-015306-us58wwmp 4471 27 l l NN cord-015306-us58wwmp 4471 28 for for IN cord-015306-us58wwmp 4471 29 the the DT cord-015306-us58wwmp 4471 30 moment moment NN cord-015306-us58wwmp 4471 31 of of IN cord-015306-us58wwmp 4471 32 developing develop VBG cord-015306-us58wwmp 4471 33 of of IN cord-015306-us58wwmp 4471 34 AMR AMR NNP cord-015306-us58wwmp 4471 35 . . . cord-015306-us58wwmp 4472 1 Function function NN cord-015306-us58wwmp 4472 2 of of IN cord-015306-us58wwmp 4472 3 the the DT cord-015306-us58wwmp 4472 4 graft graft NN cord-015306-us58wwmp 4472 5 has have VBZ cord-015306-us58wwmp 4472 6 been be VBN cord-015306-us58wwmp 4472 7 restored restore VBN cord-015306-us58wwmp 4472 8 to to IN cord-015306-us58wwmp 4472 9 satisfied satisfied JJ cord-015306-us58wwmp 4472 10 : : : cord-015306-us58wwmp 4473 1 Cr Cr NNP cord-015306-us58wwmp 4473 2 fall fall NN cord-015306-us58wwmp 4473 3 to to IN cord-015306-us58wwmp 4473 4 121±28 121±28 CD cord-015306-us58wwmp 4473 5 umol umol NNP cord-015306-us58wwmp 4473 6 / / SYM cord-015306-us58wwmp 4473 7 l l NN cord-015306-us58wwmp 4473 8 , , , cord-015306-us58wwmp 4473 9 there there EX cord-015306-us58wwmp 4473 10 were be VBD cord-015306-us58wwmp 4473 11 no no DT cord-015306-us58wwmp 4473 12 proteinuria proteinuria NN cord-015306-us58wwmp 4473 13 . . . cord-015306-us58wwmp 4474 1 It -PRON- PRP cord-015306-us58wwmp 4474 2 was be VBD cord-015306-us58wwmp 4474 3 noted note VBN cord-015306-us58wwmp 4474 4 a a DT cord-015306-us58wwmp 4474 5 significant significant JJ cord-015306-us58wwmp 4474 6 reduction reduction NN cord-015306-us58wwmp 4474 7 of of IN cord-015306-us58wwmp 4474 8 DSA DSA NNP cord-015306-us58wwmp 4474 9 I I NNP cord-015306-us58wwmp 4474 10 and and CC cord-015306-us58wwmp 4474 11 II II NNP cord-015306-us58wwmp 4474 12 class class NN cord-015306-us58wwmp 4474 13 in in IN cord-015306-us58wwmp 4474 14 3 3 CD cord-015306-us58wwmp 4474 15 from from IN cord-015306-us58wwmp 4474 16 4 4 CD cord-015306-us58wwmp 4474 17 patients patient NNS cord-015306-us58wwmp 4474 18 . . . cord-015306-us58wwmp 4475 1 Conclusion conclusion NN cord-015306-us58wwmp 4475 2 : : : cord-015306-us58wwmp 4476 1 Thus thus RB cord-015306-us58wwmp 4476 2 , , , cord-015306-us58wwmp 4476 3 treatment treatment NN cord-015306-us58wwmp 4476 4 of of IN cord-015306-us58wwmp 4476 5 an an DT cord-015306-us58wwmp 4476 6 AMR AMR NNP cord-015306-us58wwmp 4476 7 of of IN cord-015306-us58wwmp 4476 8 the the DT cord-015306-us58wwmp 4476 9 graft graft NN cord-015306-us58wwmp 4476 10 with with IN cord-015306-us58wwmp 4476 11 methylprednisolone methylprednisolone NN cord-015306-us58wwmp 4476 12 , , , cord-015306-us58wwmp 4476 13 rituximab rituximab NN cord-015306-us58wwmp 4476 14 and and CC cord-015306-us58wwmp 4476 15 immunoglobulin immunoglobulin NN cord-015306-us58wwmp 4476 16 intravenously intravenously RB cord-015306-us58wwmp 4476 17 let let VBD cord-015306-us58wwmp 4476 18 us -PRON- PRP cord-015306-us58wwmp 4476 19 achieve achieve VB cord-015306-us58wwmp 4476 20 100 100 CD cord-015306-us58wwmp 4476 21 % % NN cord-015306-us58wwmp 4476 22 1-year 1-year CD cord-015306-us58wwmp 4476 23 graft graft NN cord-015306-us58wwmp 4476 24 and and CC cord-015306-us58wwmp 4476 25 recipient recipient NN cord-015306-us58wwmp 4476 26 survival survival NN cord-015306-us58wwmp 4476 27 after after IN cord-015306-us58wwmp 4476 28 deceased deceased JJ cord-015306-us58wwmp 4476 29 donor donor NN cord-015306-us58wwmp 4476 30 kidney kidney NN cord-015306-us58wwmp 4476 31 transplantation transplantation NN cord-015306-us58wwmp 4476 32 in in IN cord-015306-us58wwmp 4476 33 children child NNS cord-015306-us58wwmp 4476 34 . . . cord-015306-us58wwmp 4477 1 Since since IN cord-015306-us58wwmp 4477 2 the the DT cord-015306-us58wwmp 4477 3 risk risk NN cord-015306-us58wwmp 4477 4 of of IN cord-015306-us58wwmp 4477 5 AMRdevelopment AMRdevelopment NNP cord-015306-us58wwmp 4477 6 is be VBZ cord-015306-us58wwmp 4477 7 high high JJ cord-015306-us58wwmp 4477 8 in in IN cord-015306-us58wwmp 4477 9 children child NNS cord-015306-us58wwmp 4477 10 with with IN cord-015306-us58wwmp 4477 11 high high JJ cord-015306-us58wwmp 4477 12 levels level NNS cord-015306-us58wwmp 4477 13 of of IN cord-015306-us58wwmp 4477 14 preexisting preexist VBG cord-015306-us58wwmp 4477 15 antibodies antibody NNS cord-015306-us58wwmp 4477 16 , , , cord-015306-us58wwmp 4477 17 addition addition NN cord-015306-us58wwmp 4477 18 of of IN cord-015306-us58wwmp 4477 19 one one CD cord-015306-us58wwmp 4477 20 - - HYPH cord-015306-us58wwmp 4477 21 time time NN cord-015306-us58wwmp 4477 22 rituximab rituximab NN cord-015306-us58wwmp 4477 23 and and CC cord-015306-us58wwmp 4477 24 immunoglobulin immunoglobulin NN cord-015306-us58wwmp 4477 25 intraveneously intraveneously NN cord-015306-us58wwmp 4477 26 in in IN cord-015306-us58wwmp 4477 27 therapy therapy NN cord-015306-us58wwmp 4477 28 seems seem VBZ cord-015306-us58wwmp 4477 29 reasonable reasonable JJ cord-015306-us58wwmp 4477 30 . . . cord-015306-us58wwmp 4478 1 Abstract abstract JJ cord-015306-us58wwmp 4478 2 # # NN cord-015306-us58wwmp 4479 1 P p NN cord-015306-us58wwmp 4479 2 - - HYPH cord-015306-us58wwmp 4479 3 SAT454 SAT454 NNP cord-015306-us58wwmp 4479 4 Tacrolimus Tacrolimus NNP cord-015306-us58wwmp 4479 5 granules granule NNS cord-015306-us58wwmp 4479 6 use use NN cord-015306-us58wwmp 4479 7 in in IN cord-015306-us58wwmp 4479 8 kidney kidney NN cord-015306-us58wwmp 4479 9 transplanted transplant VBN cord-015306-us58wwmp 4479 10 infants infant NNS cord-015306-us58wwmp 4479 11 . . . cord-015306-us58wwmp 4480 1 Dose dose NN cord-015306-us58wwmp 4480 2 and and CC cord-015306-us58wwmp 4480 3 safety safety NN cord-015306-us58wwmp 4480 4 . . . cord-015306-us58wwmp 4481 1 Ramon Ramon NNP cord-015306-us58wwmp 4481 2 Vilalta Vilalta NNP cord-015306-us58wwmp 4481 3 , , , cord-015306-us58wwmp 4481 4 Enrique Enrique NNP cord-015306-us58wwmp 4481 5 Lara Lara NNP cord-015306-us58wwmp 4481 6 , , , cord-015306-us58wwmp 4481 7 Alvaro Alvaro NNP cord-015306-us58wwmp 4481 8 Madrid Madrid NNP cord-015306-us58wwmp 4481 9 , , , cord-015306-us58wwmp 4481 10 Marina Marina NNP cord-015306-us58wwmp 4481 11 Munoz Munoz NNP cord-015306-us58wwmp 4481 12 , , , cord-015306-us58wwmp 4481 13 Sara Sara NNP cord-015306-us58wwmp 4481 14 Chocron Chocron NNP cord-015306-us58wwmp 4481 15 , , , cord-015306-us58wwmp 4481 16 Gema Gema NNP cord-015306-us58wwmp 4481 17 Ariceta Ariceta NNP cord-015306-us58wwmp 4481 18 Paediatric Paediatric NNP cord-015306-us58wwmp 4481 19 Nephrology Nephrology NNP cord-015306-us58wwmp 4481 20 , , , cord-015306-us58wwmp 4481 21 HospValld'Hebron HospValld'Hebron NNP cord-015306-us58wwmp 4481 22 , , , cord-015306-us58wwmp 4481 23 Barcelona Barcelona NNP cord-015306-us58wwmp 4481 24 , , , cord-015306-us58wwmp 4481 25 SpainObjective SpainObjective NNP cord-015306-us58wwmp 4481 26 : : : cord-015306-us58wwmp 4481 27 Tacrolimus Tacrolimus NNP cord-015306-us58wwmp 4481 28 in in IN cord-015306-us58wwmp 4481 29 infants infant NNS cord-015306-us58wwmp 4481 30 has have VBZ cord-015306-us58wwmp 4481 31 been be VBN cord-015306-us58wwmp 4481 32 administered administer VBN cord-015306-us58wwmp 4481 33 as as IN cord-015306-us58wwmp 4481 34 an an DT cord-015306-us58wwmp 4481 35 extemporaneously extemporaneously RB cord-015306-us58wwmp 4481 36 compounded compound VBN cord-015306-us58wwmp 4481 37 oral oral JJ cord-015306-us58wwmp 4481 38 liquid liquid NN cord-015306-us58wwmp 4481 39 made make VBN cord-015306-us58wwmp 4481 40 by by IN cord-015306-us58wwmp 4481 41 hospital hospital NN cord-015306-us58wwmp 4481 42 pharmacy pharmacy NN cord-015306-us58wwmp 4481 43 . . . cord-015306-us58wwmp 4482 1 Modigraf Modigraf NNP cord-015306-us58wwmp 4482 2 ® ® NNP cord-015306-us58wwmp 4482 3 is be VBZ cord-015306-us58wwmp 4482 4 a a DT cord-015306-us58wwmp 4482 5 new new JJ cord-015306-us58wwmp 4482 6 tacrolimus tacrolimus NN cord-015306-us58wwmp 4482 7 formulation formulation NN cord-015306-us58wwmp 4482 8 available available JJ cord-015306-us58wwmp 4482 9 as as IN cord-015306-us58wwmp 4482 10 sachets sachet NNS cord-015306-us58wwmp 4482 11 containing contain VBG cord-015306-us58wwmp 4482 12 granules granule NNS cord-015306-us58wwmp 4482 13 ( ( -LRB- cord-015306-us58wwmp 4482 14 0.2 0.2 CD cord-015306-us58wwmp 4482 15 mg mg NN cord-015306-us58wwmp 4482 16 and and CC cord-015306-us58wwmp 4482 17 1 1 CD cord-015306-us58wwmp 4482 18 mg mg CD cord-015306-us58wwmp 4482 19 ) ) -RRB- cord-015306-us58wwmp 4482 20 , , , cord-015306-us58wwmp 4482 21 that that WDT cord-015306-us58wwmp 4482 22 are be VBP cord-015306-us58wwmp 4482 23 made make VBN cord-015306-us58wwmp 4482 24 up up RP cord-015306-us58wwmp 4482 25 with with IN cord-015306-us58wwmp 4482 26 water water NN cord-015306-us58wwmp 4482 27 , , , cord-015306-us58wwmp 4482 28 prepared prepare VBN cord-015306-us58wwmp 4482 29 by by IN cord-015306-us58wwmp 4482 30 parents parent NNS cord-015306-us58wwmp 4482 31 or or CC cord-015306-us58wwmp 4482 32 caregivers caregiver NNS cord-015306-us58wwmp 4482 33 . . . cord-015306-us58wwmp 4483 1 Modigraf Modigraf NNP cord-015306-us58wwmp 4483 2 ® ® NNP cord-015306-us58wwmp 4483 3 is be VBZ cord-015306-us58wwmp 4483 4 considered consider VBN cord-015306-us58wwmp 4483 5 at at IN cord-015306-us58wwmp 4483 6 least least JJS cord-015306-us58wwmp 4483 7 as as RB cord-015306-us58wwmp 4483 8 safe safe JJ cord-015306-us58wwmp 4483 9 and and CC cord-015306-us58wwmp 4483 10 practical practical JJ cord-015306-us58wwmp 4483 11 than than IN cord-015306-us58wwmp 4483 12 the the DT cord-015306-us58wwmp 4483 13 compounded compound VBN cord-015306-us58wwmp 4483 14 oral oral JJ cord-015306-us58wwmp 4483 15 tacrolimus tacrolimus NN cord-015306-us58wwmp 4483 16 liquid liquid NN cord-015306-us58wwmp 4483 17 . . . cord-015306-us58wwmp 4484 1 Furthermore furthermore RB cord-015306-us58wwmp 4484 2 , , , cord-015306-us58wwmp 4484 3 it -PRON- PRP cord-015306-us58wwmp 4484 4 is be VBZ cord-015306-us58wwmp 4484 5 easier easy JJR cord-015306-us58wwmp 4484 6 to to TO cord-015306-us58wwmp 4484 7 be be VB cord-015306-us58wwmp 4484 8 stored store VBN cord-015306-us58wwmp 4484 9 and and CC cord-015306-us58wwmp 4484 10 ready ready JJ cord-015306-us58wwmp 4484 11 to to TO cord-015306-us58wwmp 4484 12 use use VB cord-015306-us58wwmp 4484 13 , , , cord-015306-us58wwmp 4484 14 and and CC cord-015306-us58wwmp 4484 15 promotes promote VBZ cord-015306-us58wwmp 4484 16 patient patient NN cord-015306-us58wwmp 4484 17 's 's POS cord-015306-us58wwmp 4484 18 autonomy autonomy NN cord-015306-us58wwmp 4484 19 , , , cord-015306-us58wwmp 4484 20 preventing prevent VBG cord-015306-us58wwmp 4484 21 potential potential JJ cord-015306-us58wwmp 4484 22 medication medication NN cord-015306-us58wwmp 4484 23 errors error NNS cord-015306-us58wwmp 4484 24 . . . cord-015306-us58wwmp 4485 1 9 9 CD cord-015306-us58wwmp 4485 2 kidney kidney NN cord-015306-us58wwmp 4485 3 transplanted transplant VBN cord-015306-us58wwmp 4485 4 infants infant NNS cord-015306-us58wwmp 4485 5 , , , cord-015306-us58wwmp 4485 6 3 3 CD cord-015306-us58wwmp 4485 7 de de JJ cord-015306-us58wwmp 4485 8 - - HYPH cord-015306-us58wwmp 4485 9 novo novo NNP cord-015306-us58wwmp 4485 10 and and CC cord-015306-us58wwmp 4485 11 6 6 CD cord-015306-us58wwmp 4485 12 converted convert VBD cord-015306-us58wwmp 4485 13 from from IN cord-015306-us58wwmp 4485 14 oral oral JJ cord-015306-us58wwmp 4485 15 liquid liquid NN cord-015306-us58wwmp 4485 16 to to IN cord-015306-us58wwmp 4486 1 Modigraf Modigraf NNP cord-015306-us58wwmp 4486 2 ® ® , cord-015306-us58wwmp 4486 3 were be VBD cord-015306-us58wwmp 4486 4 evaluated evaluate VBN cord-015306-us58wwmp 4486 5 to to TO cord-015306-us58wwmp 4486 6 assess assess VB cord-015306-us58wwmp 4486 7 its -PRON- PRP$ cord-015306-us58wwmp 4486 8 safety safety NN cord-015306-us58wwmp 4486 9 and and CC cord-015306-us58wwmp 4486 10 adequate adequate JJ cord-015306-us58wwmp 4486 11 dose dose NN cord-015306-us58wwmp 4486 12 . . . cord-015306-us58wwmp 4487 1 Methods method NNS cord-015306-us58wwmp 4487 2 : : : cord-015306-us58wwmp 4487 3 After after IN cord-015306-us58wwmp 4487 4 induction induction NN cord-015306-us58wwmp 4487 5 with with IN cord-015306-us58wwmp 4487 6 Basiliximab Basiliximab NNP cord-015306-us58wwmp 4487 7 or or CC cord-015306-us58wwmp 4487 8 ATG ATG NNP cord-015306-us58wwmp 4487 9 , , , cord-015306-us58wwmp 4487 10 de de NNP cord-015306-us58wwmp 4487 11 novo's3 novo's3 NNP cord-015306-us58wwmp 4487 12 patients patient NNS cord-015306-us58wwmp 4487 13 were be VBD cord-015306-us58wwmp 4487 14 treated treat VBN cord-015306-us58wwmp 4487 15 with with IN cord-015306-us58wwmp 4487 16 Modigraf Modigraf NNP cord-015306-us58wwmp 4487 17 ® ® NNP cord-015306-us58wwmp 4487 18 associated associate VBN cord-015306-us58wwmp 4487 19 with with IN cord-015306-us58wwmp 4487 20 MMF MMF NNP cord-015306-us58wwmp 4487 21 and and CC cord-015306-us58wwmp 4487 22 with with IN cord-015306-us58wwmp 4487 23 tapered tapered JJ cord-015306-us58wwmp 4487 24 steroids steroid NNS cord-015306-us58wwmp 4487 25 . . . cord-015306-us58wwmp 4488 1 6 6 CD cord-015306-us58wwmp 4488 2 infants infant NNS cord-015306-us58wwmp 4488 3 with with IN cord-015306-us58wwmp 4488 4 similar similar JJ cord-015306-us58wwmp 4488 5 immunosuppression immunosuppression NN cord-015306-us58wwmp 4488 6 regimen regimen NN cord-015306-us58wwmp 4488 7 were be VBD cord-015306-us58wwmp 4488 8 converted convert VBN cord-015306-us58wwmp 4488 9 from from IN cord-015306-us58wwmp 4488 10 oral oral JJ cord-015306-us58wwmp 4488 11 tacrolimus tacrolimus NN cord-015306-us58wwmp 4488 12 to to IN cord-015306-us58wwmp 4488 13 Modigraf Modigraf NNP cord-015306-us58wwmp 4488 14 ® ® NNP cord-015306-us58wwmp 4488 15 . . . cord-015306-us58wwmp 4489 1 Target target VB cord-015306-us58wwmp 4489 2 tacrolimus tacrolimus NN cord-015306-us58wwmp 4489 3 through through IN cord-015306-us58wwmp 4489 4 level level NN cord-015306-us58wwmp 4489 5 was be VBD cord-015306-us58wwmp 4489 6 8 8 CD cord-015306-us58wwmp 4489 7 - - SYM cord-015306-us58wwmp 4489 8 10 10 CD cord-015306-us58wwmp 4489 9 ng ng NN cord-015306-us58wwmp 4489 10 / / SYM cord-015306-us58wwmp 4489 11 ml ml NN cord-015306-us58wwmp 4489 12 . . . cord-015306-us58wwmp 4490 1 Mean mean JJ cord-015306-us58wwmp 4490 2 patients patient NNS cord-015306-us58wwmp 4490 3 ' ' POS cord-015306-us58wwmp 4490 4 age age NN cord-015306-us58wwmp 4490 5 at at IN cord-015306-us58wwmp 4490 6 transplantation transplantation NN cord-015306-us58wwmp 4490 7 was be VBD cord-015306-us58wwmp 4490 8 2.2 2.2 CD cord-015306-us58wwmp 4490 9 years year NNS cord-015306-us58wwmp 4490 10 old old JJ cord-015306-us58wwmp 4490 11 , , , cord-015306-us58wwmp 4490 12 and and CC cord-015306-us58wwmp 4490 13 mean mean VB cord-015306-us58wwmp 4490 14 follow follow VB cord-015306-us58wwmp 4490 15 - - HYPH cord-015306-us58wwmp 4490 16 up up NN cord-015306-us58wwmp 4490 17 period period NN cord-015306-us58wwmp 4490 18 with with IN cord-015306-us58wwmp 4490 19 Modigraf Modigraf NNP cord-015306-us58wwmp 4491 1 ® ® NNP cord-015306-us58wwmp 4491 2 was be VBD cord-015306-us58wwmp 4491 3 10±8 10±8 CD cord-015306-us58wwmp 4491 4 months month NNS cord-015306-us58wwmp 4491 5 . . . cord-015306-us58wwmp 4492 1 Results result NNS cord-015306-us58wwmp 4492 2 : : : cord-015306-us58wwmp 4493 1 In in IN cord-015306-us58wwmp 4493 2 the the DT cord-015306-us58wwmp 4493 3 de de JJ cord-015306-us58wwmp 4493 4 - - NN cord-015306-us58wwmp 4493 5 novogroup novogroup NNP cord-015306-us58wwmp 4493 6 the the DT cord-015306-us58wwmp 4493 7 stable stable JJ cord-015306-us58wwmp 4493 8 Modigraf Modigraf NNP cord-015306-us58wwmp 4493 9 ® ® POS cord-015306-us58wwmp 4493 10 dose dose NN cord-015306-us58wwmp 4493 11 needed need VBN cord-015306-us58wwmp 4493 12 to to TO cord-015306-us58wwmp 4493 13 reach reach VB cord-015306-us58wwmp 4493 14 target target NN cord-015306-us58wwmp 4493 15 levels level NNS cord-015306-us58wwmp 4493 16 was be VBD cord-015306-us58wwmp 4493 17 0.28±0.12 0.28±0.12 CD cord-015306-us58wwmp 4493 18 mg mg NNP cord-015306-us58wwmp 4493 19 / / SYM cord-015306-us58wwmp 4493 20 kg kg NNP cord-015306-us58wwmp 4493 21 / / SYM cord-015306-us58wwmp 4493 22 day day NN cord-015306-us58wwmp 4493 23 . . . cord-015306-us58wwmp 4494 1 In in IN cord-015306-us58wwmp 4494 2 the the DT cord-015306-us58wwmp 4494 3 converted converted JJ cord-015306-us58wwmp 4494 4 group group NN cord-015306-us58wwmp 4494 5 , , , cord-015306-us58wwmp 4494 6 the the DT cord-015306-us58wwmp 4494 7 initial initial JJ cord-015306-us58wwmp 4494 8 oral oral JJ cord-015306-us58wwmp 4494 9 tacrolimus tacrolimus NN cord-015306-us58wwmp 4494 10 liquid liquid NN cord-015306-us58wwmp 4494 11 dose dose NN cord-015306-us58wwmp 4494 12 was be VBD cord-015306-us58wwmp 4494 13 0.20±0.12 0.20±0.12 CD cord-015306-us58wwmp 4495 1 mg mg NNP cord-015306-us58wwmp 4495 2 / / SYM cord-015306-us58wwmp 4495 3 kg kg NNP cord-015306-us58wwmp 4495 4 / / SYM cord-015306-us58wwmp 4495 5 day day NN cord-015306-us58wwmp 4495 6 , , , cord-015306-us58wwmp 4495 7 whereas whereas IN cord-015306-us58wwmp 4495 8 Modigraf Modigraf NNP cord-015306-us58wwmp 4495 9 ® ® POS cord-015306-us58wwmp 4495 10 stable stable JJ cord-015306-us58wwmp 4495 11 required require VBN cord-015306-us58wwmp 4495 12 dose dose NN cord-015306-us58wwmp 4495 13 was be VBD cord-015306-us58wwmp 4495 14 higher high JJR cord-015306-us58wwmp 4495 15 : : : cord-015306-us58wwmp 4495 16 0.30±0.10 0.30±0.10 CD cord-015306-us58wwmp 4496 1 mg mg NNP cord-015306-us58wwmp 4496 2 / / SYM cord-015306-us58wwmp 4496 3 kg kg NNP cord-015306-us58wwmp 4496 4 / / SYM cord-015306-us58wwmp 4496 5 day day NN cord-015306-us58wwmp 4496 6 ( ( -LRB- cord-015306-us58wwmp 4496 7 p p NN cord-015306-us58wwmp 4496 8 = = SYM cord-015306-us58wwmp 4496 9 0.0003 0.0003 CD cord-015306-us58wwmp 4496 10 ) ) -RRB- cord-015306-us58wwmp 4496 11 . . . cord-015306-us58wwmp 4497 1 Target target NN cord-015306-us58wwmp 4497 2 levels level NNS cord-015306-us58wwmp 4497 3 of of IN cord-015306-us58wwmp 4497 4 tacrolimus tacrolimus NN cord-015306-us58wwmp 4497 5 were be VBD cord-015306-us58wwmp 4497 6 reached reach VBN cord-015306-us58wwmp 4497 7 after after IN