id	sid	tid	token	lemma	pos
cord-006860-a3b8hyyr	1	1	key	key	NN
cord-006860-a3b8hyyr	1	2	:	:	:
cord-006860-a3b8hyyr	2	1	cord-006860-a3b8hyyr	cord-006860-a3b8hyyr	NNP
cord-006860-a3b8hyyr	2	2	authors	author	NNS
cord-006860-a3b8hyyr	2	3	:	:	:
cord-006860-a3b8hyyr	2	4	nan	nan	NNP
cord-006860-a3b8hyyr	2	5	title	title	NN
cord-006860-a3b8hyyr	2	6	:	:	:
cord-006860-a3b8hyyr	2	7	40th	40th	JJ
cord-006860-a3b8hyyr	2	8	Annual	Annual	NNP
cord-006860-a3b8hyyr	2	9	Meeting	Meeting	NNP
cord-006860-a3b8hyyr	2	10	of	of	IN
cord-006860-a3b8hyyr	2	11	the	the	DT
cord-006860-a3b8hyyr	2	12	GTH	GTH	NNP
cord-006860-a3b8hyyr	3	1	(	(	-LRB-
cord-006860-a3b8hyyr	3	2	Gesellschaft	Gesellschaft	NNP
cord-006860-a3b8hyyr	3	3	für	für	IN
cord-006860-a3b8hyyr	3	4	Thrombose-	thrombose-	NN
cord-006860-a3b8hyyr	4	1	und	und	NNP
cord-006860-a3b8hyyr	4	2	Hämostaseforschung	Hämostaseforschung	NNP
cord-006860-a3b8hyyr	4	3	)	)	-RRB-
cord-006860-a3b8hyyr	4	4	date	date	NN
cord-006860-a3b8hyyr	4	5	:	:	:
cord-006860-a3b8hyyr	4	6	1996	1996	CD
cord-006860-a3b8hyyr	4	7	journal	journal	NN
cord-006860-a3b8hyyr	4	8	:	:	:
cord-006860-a3b8hyyr	5	1	Ann	Ann	NNP
cord-006860-a3b8hyyr	5	2	Hematol	Hematol	NNP
cord-006860-a3b8hyyr	5	3	DOI	DOI	NNP
cord-006860-a3b8hyyr	5	4	:	:	:
cord-006860-a3b8hyyr	6	1	10.1007	10.1007	CD
cord-006860-a3b8hyyr	6	2	/	/	SYM
cord-006860-a3b8hyyr	6	3	bf00641048	bf00641048	NNP
cord-006860-a3b8hyyr	6	4	sha	sha	NNP
cord-006860-a3b8hyyr	6	5	:	:	:
cord-006860-a3b8hyyr	6	6	ae8ae371d81dc4d9fb081640473291444bcb4c27	ae8ae371d81dc4d9fb081640473291444bcb4c27	NNP
cord-006860-a3b8hyyr	6	7	doc_id	doc_id	CD
cord-006860-a3b8hyyr	6	8	:	:	:
cord-006860-a3b8hyyr	6	9	6860	6860	CD
cord-006860-a3b8hyyr	6	10	cord_uid	cord_uid	NNS
cord-006860-a3b8hyyr	6	11	:	:	:
cord-006860-a3b8hyyr	6	12	a3b8hyyr	a3b8hyyr	.
cord-006860-a3b8hyyr	7	1	nan	nan	NNP
cord-006860-a3b8hyyr	8	1	The	the	DT
cord-006860-a3b8hyyr	8	2	variable	variable	JJ
cord-006860-a3b8hyyr	8	3	molecular	molecular	JJ
cord-006860-a3b8hyyr	8	4	weight	weight	NN
cord-006860-a3b8hyyr	8	5	(	(	-LRB-
cord-006860-a3b8hyyr	8	6	MW	MW	NNP
cord-006860-a3b8hyyr	8	7	)	)	-RRB-
cord-006860-a3b8hyyr	8	8	of	of	IN
cord-006860-a3b8hyyr	8	9	vWF	vWF	NNP
cord-006860-a3b8hyyr	8	10	is	be	VBZ
cord-006860-a3b8hyyr	8	11	due	due	JJ
cord-006860-a3b8hyyr	8	12	to	to	IN
cord-006860-a3b8hyyr	8	13	differences	difference	NNS
cord-006860-a3b8hyyr	8	14	in	in	IN
cord-006860-a3b8hyyr	8	15	the	the	DT
cord-006860-a3b8hyyr	8	16	number	number	NN
cord-006860-a3b8hyyr	8	17	of	of	IN
cord-006860-a3b8hyyr	8	18	subunits	subunit	NNS
cord-006860-a3b8hyyr	8	19	comprising	comprise	VBG
cord-006860-a3b8hyyr	8	20	the	the	DT
cord-006860-a3b8hyyr	8	21	protein	protein	NN
cord-006860-a3b8hyyr	8	22	.	.	.
cord-006860-a3b8hyyr	9	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	9	2	is	be	VBZ
cord-006860-a3b8hyyr	9	3	assumed	assume	VBN
cord-006860-a3b8hyyr	9	4	that	that	IN
cord-006860-a3b8hyyr	9	5	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	9	6	cells	cell	NNS
cord-006860-a3b8hyyr	9	7	secrete	secrete	VBP
cord-006860-a3b8hyyr	9	8	large	large	JJ
cord-006860-a3b8hyyr	9	9	polymeric	polymeric	JJ
cord-006860-a3b8hyyr	9	10	forms	form	NNS
cord-006860-a3b8hyyr	9	11	of	of	IN
cord-006860-a3b8hyyr	9	12	vWF	vwf	NN
cord-006860-a3b8hyyr	9	13	and	and	CC
cord-006860-a3b8hyyr	9	14	that	that	IN
cord-006860-a3b8hyyr	9	15	smaller	small	JJR
cord-006860-a3b8hyyr	9	16	species	specie	NNS
cord-006860-a3b8hyyr	9	17	arise	arise	VBP
cord-006860-a3b8hyyr	9	18	from	from	IN
cord-006860-a3b8hyyr	9	19	proteolytic	proteolytic	JJ
cord-006860-a3b8hyyr	9	20	cleavage	cleavage	NN
cord-006860-a3b8hyyr	9	21	.	.	.
cord-006860-a3b8hyyr	10	1	vWF	vWF	NNP
cord-006860-a3b8hyyr	10	2	has	have	VBZ
cord-006860-a3b8hyyr	10	3	two	two	CD
cord-006860-a3b8hyyr	10	4	main	main	JJ
cord-006860-a3b8hyyr	10	5	properties	property	NNS
cord-006860-a3b8hyyr	10	6	:	:	:
cord-006860-a3b8hyyr	10	7	it	-PRON-	PRP
cord-006860-a3b8hyyr	10	8	stabilizes	stabilize	VBZ
cord-006860-a3b8hyyr	10	9	factor	factor	NN
cord-006860-a3b8hyyr	10	10	VIII	VIII	NNP
cord-006860-a3b8hyyr	10	11	protecting	protect	VBG
cord-006860-a3b8hyyr	10	12	it	-PRON-	PRP
cord-006860-a3b8hyyr	10	13	from	from	IN
cord-006860-a3b8hyyr	10	14	inactivation	inactivation	NN
cord-006860-a3b8hyyr	10	15	by	by	IN
cord-006860-a3b8hyyr	10	16	activated	activate	VBN
cord-006860-a3b8hyyr	10	17	protein	protein	NN
cord-006860-a3b8hyyr	10	18	C	c	NN
cord-006860-a3b8hyyr	10	19	or	or	CC
cord-006860-a3b8hyyr	10	20	factor	factor	NN
cord-006860-a3b8hyyr	11	1	Xa	Xa	NNP
cord-006860-a3b8hyyr	11	2	,	,	,
cord-006860-a3b8hyyr	11	3	and	and	CC
cord-006860-a3b8hyyr	11	4	it	-PRON-	PRP
cord-006860-a3b8hyyr	11	5	mediates	mediate	VBZ
cord-006860-a3b8hyyr	11	6	platelet	platelet	JJ
cord-006860-a3b8hyyr	11	7	adhesion	adhesion	NN
cord-006860-a3b8hyyr	11	8	to	to	IN
cord-006860-a3b8hyyr	11	9	subendothelium	subendothelium	NN
cord-006860-a3b8hyyr	11	10	of	of	IN
cord-006860-a3b8hyyr	11	11	the	the	DT
cord-006860-a3b8hyyr	11	12	damaged	damage	VBN
cord-006860-a3b8hyyr	11	13	blood	blood	NN
cord-006860-a3b8hyyr	11	14	vessel	vessel	NN
cord-006860-a3b8hyyr	11	15	wall	wall	NN
cord-006860-a3b8hyyr	11	16	.	.	.
cord-006860-a3b8hyyr	12	1	Each	each	DT
cord-006860-a3b8hyyr	12	2	vWF	vwf	IN
cord-006860-a3b8hyyr	12	3	subunit	subunit	NN
cord-006860-a3b8hyyr	12	4	contains	contain	VBZ
cord-006860-a3b8hyyr	12	5	binding	bind	VBG
cord-006860-a3b8hyyr	12	6	sites	site	NNS
cord-006860-a3b8hyyr	12	7	for	for	IN
cord-006860-a3b8hyyr	12	8	collagen	collagen	NN
cord-006860-a3b8hyyr	12	9	and	and	CC
cord-006860-a3b8hyyr	12	10	for	for	IN
cord-006860-a3b8hyyr	12	11	platelet	platelet	NN
cord-006860-a3b8hyyr	12	12	giycoproteins	giycoprotein	NNS
cord-006860-a3b8hyyr	12	13	GP	GP	NNP
cord-006860-a3b8hyyr	12	14	Ib	Ib	NNP
cord-006860-a3b8hyyr	12	15	and	and	CC
cord-006860-a3b8hyyr	12	16	GP	GP	NNP
cord-006860-a3b8hyyr	12	17	IIb/	IIb/	NNP
cord-006860-a3b8hyyr	13	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	13	2	~	~	NFP
cord-006860-a3b8hyyr	13	3	a	a	DT
cord-006860-a3b8hyyr	13	4	.	.	.
cord-006860-a3b8hyyr	14	1	Multiple	multiple	JJ
cord-006860-a3b8hyyr	14	2	interactions	interaction	NNS
cord-006860-a3b8hyyr	14	3	of	of	IN
cord-006860-a3b8hyyr	14	4	the	the	DT
cord-006860-a3b8hyyr	14	5	multivalent	multivalent	JJ
cord-006860-a3b8hyyr	14	6	vWF	vwf	IN
cord-006860-a3b8hyyr	14	7	lead	lead	NN
cord-006860-a3b8hyyr	14	8	to	to	IN
cord-006860-a3b8hyyr	14	9	extremely	extremely	RB
cord-006860-a3b8hyyr	14	10	strong	strong	JJ
cord-006860-a3b8hyyr	14	11	binding	binding	NN
cord-006860-a3b8hyyr	14	12	of	of	IN
cord-006860-a3b8hyyr	14	13	platelets	platelet	NNS
cord-006860-a3b8hyyr	14	14	to	to	IN
cord-006860-a3b8hyyr	14	15	subendothelial	subendothelial	JJ
cord-006860-a3b8hyyr	14	16	surface	surface	NN
cord-006860-a3b8hyyr	14	17	,	,	,
cord-006860-a3b8hyyr	14	18	that	that	WDT
cord-006860-a3b8hyyr	14	19	is	be	VBZ
cord-006860-a3b8hyyr	14	20	capable	capable	JJ
cord-006860-a3b8hyyr	14	21	of	of	IN
cord-006860-a3b8hyyr	14	22	resisting	resist	VBG
cord-006860-a3b8hyyr	14	23	high	high	JJ
cord-006860-a3b8hyyr	14	24	wall	wall	NN
cord-006860-a3b8hyyr	14	25	shear	shear	NN
cord-006860-a3b8hyyr	14	26	rate	rate	NN
cord-006860-a3b8hyyr	14	27	in	in	IN
cord-006860-a3b8hyyr	14	28	the	the	DT
cord-006860-a3b8hyyr	14	29	circulating	circulate	VBG
cord-006860-a3b8hyyr	14	30	blood	blood	NN
cord-006860-a3b8hyyr	14	31	.	.	.
cord-006860-a3b8hyyr	15	1	Only	only	RB
cord-006860-a3b8hyyr	15	2	the	the	DT
cord-006860-a3b8hyyr	15	3	largest	large	JJS
cord-006860-a3b8hyyr	15	4	multimers	multimer	NNS
cord-006860-a3b8hyyr	15	5	are	be	VBP
cord-006860-a3b8hyyr	15	6	hemostatically	hemostatically	RB
cord-006860-a3b8hyyr	15	7	active	active	JJ
cord-006860-a3b8hyyr	15	8	.	.	.
cord-006860-a3b8hyyr	16	1	Lack	lack	NN
cord-006860-a3b8hyyr	16	2	of	of	IN
cord-006860-a3b8hyyr	16	3	the	the	DT
cord-006860-a3b8hyyr	16	4	largest	large	JJS
cord-006860-a3b8hyyr	16	5	vWF	vwf	NN
cord-006860-a3b8hyyr	16	6	multimers	multimers	NNP
cord-006860-a3b8hyyr	16	7	was	be	VBD
cord-006860-a3b8hyyr	16	8	observed	observe	VBN
cord-006860-a3b8hyyr	16	9	in	in	IN
cord-006860-a3b8hyyr	16	10	patients	patient	NNS
cord-006860-a3b8hyyr	16	11	with	with	IN
cord-006860-a3b8hyyr	16	12	yon	yon	NNP
cord-006860-a3b8hyyr	16	13	WiUebrand	WiUebrand	NNP
cord-006860-a3b8hyyr	16	14	disease	disease	NN
cord-006860-a3b8hyyr	16	15	type	type	NN
cord-006860-a3b8hyyr	16	16	2A.	2a.	CD
cord-006860-a3b8hyyr	16	17	Unusually	unusually	RB
cord-006860-a3b8hyyr	16	18	large	large	JJ
cord-006860-a3b8hyyr	16	19	molecular	molecular	JJ
cord-006860-a3b8hyyr	16	20	forms	form	NNS
cord-006860-a3b8hyyr	16	21	of	of	IN
cord-006860-a3b8hyyr	16	22	vWF	vwf	NN
cord-006860-a3b8hyyr	16	23	were	be	VBD
cord-006860-a3b8hyyr	16	24	found	find	VBN
cord-006860-a3b8hyyr	16	25	in	in	IN
cord-006860-a3b8hyyr	16	26	patients	patient	NNS
cord-006860-a3b8hyyr	16	27	with	with	IN
cord-006860-a3b8hyyr	16	28	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	16	29	thrombocytopenlc	thrombocytopenlc	NNP
cord-006860-a3b8hyyr	16	30	purpura	purpura	NN
cord-006860-a3b8hyyr	16	31	.	.	.
cord-006860-a3b8hyyr	17	1	Proteolytic	proteolytic	JJ
cord-006860-a3b8hyyr	17	2	enzyme(s	enzyme(s	NNP
cord-006860-a3b8hyyr	17	3	)	)	-RRB-
cord-006860-a3b8hyyr	17	4	may	may	MD
cord-006860-a3b8hyyr	17	5	be	be	VB
cord-006860-a3b8hyyr	17	6	involved	involve	VBN
cord-006860-a3b8hyyr	17	7	in	in	IN
cord-006860-a3b8hyyr	17	8	the	the	DT
cord-006860-a3b8hyyr	17	9	physiologic	physiologic	JJ
cord-006860-a3b8hyyr	17	10	regulation	regulation	NN
cord-006860-a3b8hyyr	17	11	of	of	IN
cord-006860-a3b8hyyr	17	12	the	the	DT
cord-006860-a3b8hyyr	17	13	polymeric	polymeric	JJ
cord-006860-a3b8hyyr	17	14	size	size	NN
cord-006860-a3b8hyyr	17	15	of	of	IN
cord-006860-a3b8hyyr	17	16	vWF	vwf	NN
cord-006860-a3b8hyyr	17	17	and	and	CC
cord-006860-a3b8hyyr	17	18	thus	thus	RB
cord-006860-a3b8hyyr	17	19	play	play	VB
cord-006860-a3b8hyyr	17	20	an	an	DT
cord-006860-a3b8hyyr	17	21	important	important	JJ
cord-006860-a3b8hyyr	17	22	role	role	NN
cord-006860-a3b8hyyr	17	23	in	in	IN
cord-006860-a3b8hyyr	17	24	the	the	DT
cord-006860-a3b8hyyr	17	25	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	17	26	of	of	IN
cord-006860-a3b8hyyr	17	27	vWF	vwf	NN
cord-006860-a3b8hyyr	17	28	abnormalities	abnormality	NNS
cord-006860-a3b8hyyr	17	29	in	in	IN
cord-006860-a3b8hyyr	17	30	some	some	DT
cord-006860-a3b8hyyr	17	31	patients	patient	NNS
cord-006860-a3b8hyyr	17	32	with	with	IN
cord-006860-a3b8hyyr	17	33	congenital	congenital	JJ
cord-006860-a3b8hyyr	17	34	or	or	CC
cord-006860-a3b8hyyr	17	35	acquired	acquire	VBN
cord-006860-a3b8hyyr	17	36	disorders	disorder	NNS
cord-006860-a3b8hyyr	17	37	of	of	IN
cord-006860-a3b8hyyr	17	38	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	17	39	.	.	.
cord-006860-a3b8hyyr	18	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	18	2	have	have	VBP
cord-006860-a3b8hyyr	18	3	purified	purify	VBN
cord-006860-a3b8hyyr	18	4	(	(	-LRB-
cord-006860-a3b8hyyr	18	5	-10,000-fold	-10,000-fold	RB
cord-006860-a3b8hyyr	18	6	)	)	-RRB-
cord-006860-a3b8hyyr	18	7	from	from	IN
cord-006860-a3b8hyyr	18	8	human	human	JJ
cord-006860-a3b8hyyr	18	9	plasma	plasma	NN
cord-006860-a3b8hyyr	18	10	a	a	DT
cord-006860-a3b8hyyr	18	11	vWF	vwf	NN
cord-006860-a3b8hyyr	18	12	degrading	degrade	VBG
cord-006860-a3b8hyyr	18	13	proteas¢	proteas¢	NN
cord-006860-a3b8hyyr	18	14	using	use	VBG
cord-006860-a3b8hyyr	18	15	affinity	affinity	NN
cord-006860-a3b8hyyr	18	16	chromatography	chromatography	NN
cord-006860-a3b8hyyr	18	17	and	and	CC
cord-006860-a3b8hyyr	18	18	gel	gel	NN
cord-006860-a3b8hyyr	18	19	filtration	filtration	NN
cord-006860-a3b8hyyr	18	20	.	.	.
cord-006860-a3b8hyyr	19	1	The	the	DT
cord-006860-a3b8hyyr	19	2	proteolytic	proteolytic	JJ
cord-006860-a3b8hyyr	19	3	activity	activity	NN
cord-006860-a3b8hyyr	19	4	was	be	VBD
cord-006860-a3b8hyyr	19	5	associated	associate	VBN
cord-006860-a3b8hyyr	19	6	with	with	IN
cord-006860-a3b8hyyr	19	7	a	a	DT
cord-006860-a3b8hyyr	19	8	high	high	JJ
cord-006860-a3b8hyyr	19	9	MW	mw	NN
cord-006860-a3b8hyyr	19	10	protein	protein	NN
cord-006860-a3b8hyyr	19	11	(	(	-LRB-
cord-006860-a3b8hyyr	19	12	Mr	Mr	NNP
cord-006860-a3b8hyyr	19	13	-300	-300	NNP
cord-006860-a3b8hyyr	19	14	kD	kD	NNP
cord-006860-a3b8hyyr	19	15	)	)	-RRB-
cord-006860-a3b8hyyr	19	16	.	.	.
cord-006860-a3b8hyyr	20	1	vWF	vWF	NNP
cord-006860-a3b8hyyr	20	2	was	be	VBD
cord-006860-a3b8hyyr	20	3	resistant	resistant	JJ
cord-006860-a3b8hyyr	20	4	against	against	IN
cord-006860-a3b8hyyr	20	5	the	the	DT
cord-006860-a3b8hyyr	20	6	protease	protease	NN
cord-006860-a3b8hyyr	20	7	in	in	IN
cord-006860-a3b8hyyr	20	8	a	a	DT
cord-006860-a3b8hyyr	20	9	physiologic	physiologic	JJ
cord-006860-a3b8hyyr	20	10	buffer	buffer	NN
cord-006860-a3b8hyyr	20	11	but	but	CC
cord-006860-a3b8hyyr	20	12	became	become	VBD
cord-006860-a3b8hyyr	20	13	degraded	degrade	VBN
cord-006860-a3b8hyyr	20	14	at	at	IN
cord-006860-a3b8hyyr	20	15	low	low	JJ
cord-006860-a3b8hyyr	20	16	salt	salt	NN
cord-006860-a3b8hyyr	20	17	concentration	concentration	NN
cord-006860-a3b8hyyr	20	18	or	or	CC
cord-006860-a3b8hyyr	20	19	in	in	IN
cord-006860-a3b8hyyr	20	20	the	the	DT
cord-006860-a3b8hyyr	20	21	presence	presence	NN
cord-006860-a3b8hyyr	20	22	of	of	IN
cord-006860-a3b8hyyr	20	23	1	1	CD
cord-006860-a3b8hyyr	20	24	M	M	NNP
cord-006860-a3b8hyyr	20	25	urea	urea	NN
cord-006860-a3b8hyyr	20	26	.	.	.
cord-006860-a3b8hyyr	21	1	Proteolytic	proteolytic	JJ
cord-006860-a3b8hyyr	21	2	activity	activity	NN
cord-006860-a3b8hyyr	21	3	had	have	VBD
cord-006860-a3b8hyyr	21	4	a	a	DT
cord-006860-a3b8hyyr	21	5	pH	ph	NN
cord-006860-a3b8hyyr	21	6	optimum	optimum	NN
cord-006860-a3b8hyyr	21	7	at	at	IN
cord-006860-a3b8hyyr	21	8	g-9	g-9	NNP
cord-006860-a3b8hyyr	21	9	and	and	CC
cord-006860-a3b8hyyr	21	10	was	be	VBD
cord-006860-a3b8hyyr	21	11	not	not	RB
cord-006860-a3b8hyyr	21	12	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	21	13	by	by	IN
cord-006860-a3b8hyyr	21	14	serine	serine	JJ
cord-006860-a3b8hyyr	21	15	protease	protease	NN
cord-006860-a3b8hyyr	21	16	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	21	17	or	or	CC
cord-006860-a3b8hyyr	21	18	sulfl	sulfl	NNP
cord-006860-a3b8hyyr	21	19	~	~	NFP
cord-006860-a3b8hyyr	21	20	ydryl	ydryl	NNP
cord-006860-a3b8hyyr	21	21	reagents	reagent	NNS
cord-006860-a3b8hyyr	21	22	.	.	.
cord-006860-a3b8hyyr	22	1	Inhibition	inhibition	NN
cord-006860-a3b8hyyr	22	2	by	by	IN
cord-006860-a3b8hyyr	22	3	chelating	chelate	VBG
cord-006860-a3b8hyyr	22	4	agents	agent	NNS
cord-006860-a3b8hyyr	22	5	was	be	VBD
cord-006860-a3b8hyyr	22	6	best	well	RBS
cord-006860-a3b8hyyr	22	7	reversed	reverse	VBN
cord-006860-a3b8hyyr	22	8	by	by	IN
cord-006860-a3b8hyyr	22	9	barium	barium	NN
cord-006860-a3b8hyyr	22	10	ions	ion	NNS
cord-006860-a3b8hyyr	22	11	,	,	,
cord-006860-a3b8hyyr	22	12	The	the	DT
cord-006860-a3b8hyyr	22	13	observed	observed	JJ
cord-006860-a3b8hyyr	22	14	properties	property	NNS
cord-006860-a3b8hyyr	22	15	of	of	IN
cord-006860-a3b8hyyr	22	16	the	the	DT
cord-006860-a3b8hyyr	22	17	vWF	vwf	JJ
cord-006860-a3b8hyyr	22	18	degrading	degrade	VBG
cord-006860-a3b8hyyr	22	19	enzyme	enzyme	NN
cord-006860-a3b8hyyr	22	20	differ	differ	VBP
cord-006860-a3b8hyyr	22	21	from	from	IN
cord-006860-a3b8hyyr	22	22	those	those	DT
cord-006860-a3b8hyyr	22	23	of	of	IN
cord-006860-a3b8hyyr	22	24	all	all	DT
cord-006860-a3b8hyyr	22	25	hitherto	hitherto	VBN
cord-006860-a3b8hyyr	22	26	described	describe	VBN
cord-006860-a3b8hyyr	22	27	pretenses	pretense	NNS
cord-006860-a3b8hyyr	22	28	.	.	.
cord-006860-a3b8hyyr	23	1	Analysis	analysis	NN
cord-006860-a3b8hyyr	23	2	of	of	IN
cord-006860-a3b8hyyr	23	3	cleaved	cleave	VBN
cord-006860-a3b8hyyr	23	4	vWF	vWF	NNP
cord-006860-a3b8hyyr	23	5	showed	show	VBD
cord-006860-a3b8hyyr	23	6	that	that	IN
cord-006860-a3b8hyyr	23	7	the	the	DT
cord-006860-a3b8hyyr	23	8	peptide	peptide	NN
cord-006860-a3b8hyyr	23	9	bond	bond	NN
cord-006860-a3b8hyyr	23	10	842Tyr	842tyr	CD
cord-006860-a3b8hyyr	23	11	-	-	:
cord-006860-a3b8hyyr	23	12	g43Met	g43Met	NNP
cord-006860-a3b8hyyr	23	13	had	have	VBD
cord-006860-a3b8hyyr	23	14	been	be	VBN
cord-006860-a3b8hyyr	23	15	cleaved	cleave	VBN
cord-006860-a3b8hyyr	23	16	-the	-the	DT
cord-006860-a3b8hyyr	23	17	same	same	JJ
cord-006860-a3b8hyyr	23	18	bond	bond	NN
cord-006860-a3b8hyyr	23	19	that	that	WDT
cord-006860-a3b8hyyr	23	20	has	have	VBZ
cord-006860-a3b8hyyr	23	21	been	be	VBN
cord-006860-a3b8hyyr	23	22	proposed	propose	VBN
cord-006860-a3b8hyyr	23	23	to	to	TO
cord-006860-a3b8hyyr	23	24	be	be	VB
cord-006860-a3b8hyyr	23	25	cleaved	cleave	VBN
cord-006860-a3b8hyyr	23	26	in	in	IN
cord-006860-a3b8hyyr	23	27	rive	rive	NNP
cord-006860-a3b8hyyr	23	28	.	.	.
cord-006860-a3b8hyyr	24	1	The	the	DT
cord-006860-a3b8hyyr	24	2	endothelium	endothelium	NN
cord-006860-a3b8hyyr	24	3	releases	release	VBZ
cord-006860-a3b8hyyr	24	4	the	the	DT
cord-006860-a3b8hyyr	24	5	vasodilator	vasodilator	NN
cord-006860-a3b8hyyr	24	6	nitric	nitric	NN
cord-006860-a3b8hyyr	24	7	oxide	oxide	NN
cord-006860-a3b8hyyr	24	8	(	(	-LRB-
cord-006860-a3b8hyyr	24	9	NO	no	UH
cord-006860-a3b8hyyr	24	10	)	)	-RRB-
cord-006860-a3b8hyyr	24	11	and	and	CC
cord-006860-a3b8hyyr	24	12	the	the	DT
cord-006860-a3b8hyyr	24	13	vasoconstrictor	vasoconstrictor	NN
cord-006860-a3b8hyyr	24	14	endothelin	endothelin	NN
cord-006860-a3b8hyyr	24	15	(	(	-LRB-
cord-006860-a3b8hyyr	24	16	ET)-I.	ET)-I.	NNP
cord-006860-a3b8hyyr	24	17	NO	NO	NNP
cord-006860-a3b8hyyr	24	18	is	be	VBZ
cord-006860-a3b8hyyr	24	19	formed	form	VBN
cord-006860-a3b8hyyr	24	20	from	from	IN
cord-006860-a3b8hyyr	24	21	L	l	NN
cord-006860-a3b8hyyr	24	22	-	-	HYPH
cord-006860-a3b8hyyr	24	23	arginine	arginine	NN
cord-006860-a3b8hyyr	24	24	via	via	IN
cord-006860-a3b8hyyr	24	25	the	the	DT
cord-006860-a3b8hyyr	24	26	activity	activity	NN
cord-006860-a3b8hyyr	24	27	of	of	IN
cord-006860-a3b8hyyr	24	28	constitutive	constitutive	JJ
cord-006860-a3b8hyyr	24	29	nitric	nitric	NN
cord-006860-a3b8hyyr	24	30	oxide	oxide	NN
cord-006860-a3b8hyyr	24	31	synthase	synthase	NN
cord-006860-a3b8hyyr	24	32	(	(	-LRB-
cord-006860-a3b8hyyr	24	33	cNOS	cnos	JJ
cord-006860-a3b8hyyr	24	34	or	or	CC
cord-006860-a3b8hyyr	24	35	eNOS	enos	JJ
cord-006860-a3b8hyyr	24	36	)	)	-RRB-
cord-006860-a3b8hyyr	24	37	.	.	.
cord-006860-a3b8hyyr	25	1	An	an	DT
cord-006860-a3b8hyyr	25	2	inducible	inducible	JJ
cord-006860-a3b8hyyr	25	3	form	form	NN
cord-006860-a3b8hyyr	25	4	of	of	IN
cord-006860-a3b8hyyr	25	5	NOS	NOS	NNP
cord-006860-a3b8hyyr	25	6	(	(	-LRB-
cord-006860-a3b8hyyr	25	7	iNOS	inos	NN
cord-006860-a3b8hyyr	25	8	)	)	-RRB-
cord-006860-a3b8hyyr	25	9	is	be	VBZ
cord-006860-a3b8hyyr	25	10	activated	activate	VBN
cord-006860-a3b8hyyr	25	11	by	by	IN
cord-006860-a3b8hyyr	25	12	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	25	13	.	.	.
cord-006860-a3b8hyyr	26	1	NO	no	DT
cord-006860-a3b8hyyr	26	2	activates	activate	VBZ
cord-006860-a3b8hyyr	26	3	guanylyl	guanylyl	JJ
cord-006860-a3b8hyyr	26	4	cyclase	cyclase	NN
cord-006860-a3b8hyyr	26	5	in	in	IN
cord-006860-a3b8hyyr	26	6	vascular	vascular	JJ
cord-006860-a3b8hyyr	26	7	smooth	smooth	JJ
cord-006860-a3b8hyyr	26	8	muscle	muscle	NN
cord-006860-a3b8hyyr	26	9	and	and	CC
cord-006860-a3b8hyyr	26	10	platelets	platelet	NNS
cord-006860-a3b8hyyr	26	11	,	,	,
cord-006860-a3b8hyyr	26	12	leading	lead	VBG
cord-006860-a3b8hyyr	26	13	to	to	IN
cord-006860-a3b8hyyr	26	14	the	the	DT
cord-006860-a3b8hyyr	26	15	formation	formation	NN
cord-006860-a3b8hyyr	26	16	of	of	IN
cord-006860-a3b8hyyr	26	17	cGMP	cGMP	NNP
cord-006860-a3b8hyyr	26	18	which	which	WDT
cord-006860-a3b8hyyr	26	19	induces	induce	VBZ
cord-006860-a3b8hyyr	26	20	relaxation	relaxation	NN
cord-006860-a3b8hyyr	26	21	or	or	CC
cord-006860-a3b8hyyr	26	22	platelet	platelet	NN
cord-006860-a3b8hyyr	26	23	inhibition	inhibition	NN
cord-006860-a3b8hyyr	26	24	,	,	,
cord-006860-a3b8hyyr	26	25	respectively	respectively	RB
cord-006860-a3b8hyyr	26	26	.	.	.
cord-006860-a3b8hyyr	27	1	In	in	IN
cord-006860-a3b8hyyr	27	2	vessels	vessel	NNS
cord-006860-a3b8hyyr	27	3	,	,	,
cord-006860-a3b8hyyr	27	4	NO	no	UH
cord-006860-a3b8hyyr	27	5	is	be	VBZ
cord-006860-a3b8hyyr	27	6	responsible	responsible	JJ
cord-006860-a3b8hyyr	27	7	for	for	IN
cord-006860-a3b8hyyr	27	8	endothelium	endothelium	NN
cord-006860-a3b8hyyr	27	9	-	-	HYPH
cord-006860-a3b8hyyr	27	10	dependent	dependent	JJ
cord-006860-a3b8hyyr	27	11	relaxations	relaxation	NNS
cord-006860-a3b8hyyr	27	12	;	;	:
cord-006860-a3b8hyyr	27	13	in	in	IN
cord-006860-a3b8hyyr	27	14	vivo	vivo	NN
cord-006860-a3b8hyyr	27	15	it	-PRON-	PRP
cord-006860-a3b8hyyr	27	16	exerts	exert	VBZ
cord-006860-a3b8hyyr	27	17	a	a	DT
cord-006860-a3b8hyyr	27	18	vasodilator	vasodilator	NN
cord-006860-a3b8hyyr	27	19	tone	tone	NN
cord-006860-a3b8hyyr	27	20	which	which	WDT
cord-006860-a3b8hyyr	27	21	can	can	MD
cord-006860-a3b8hyyr	27	22	be	be	VB
cord-006860-a3b8hyyr	27	23	enhanced	enhance	VBN
cord-006860-a3b8hyyr	27	24	by	by	IN
cord-006860-a3b8hyyr	27	25	shear	shear	NN
cord-006860-a3b8hyyr	27	26	forces	force	NNS
cord-006860-a3b8hyyr	27	27	and	and	CC
cord-006860-a3b8hyyr	27	28	receptor	receptor	NN
cord-006860-a3b8hyyr	27	29	-	-	HYPH
cord-006860-a3b8hyyr	27	30	operated	operate	VBN
cord-006860-a3b8hyyr	27	31	agonists	agonist	NNS
cord-006860-a3b8hyyr	27	32	such	such	JJ
cord-006860-a3b8hyyr	27	33	as	as	IN
cord-006860-a3b8hyyr	27	34	acetylcholine	acetylcholine	NN
cord-006860-a3b8hyyr	27	35	,	,	,
cord-006860-a3b8hyyr	27	36	bradykinin	bradykinin	NN
cord-006860-a3b8hyyr	27	37	,	,	,
cord-006860-a3b8hyyr	27	38	thrombin	thrombin	NN
cord-006860-a3b8hyyr	27	39	,	,	,
cord-006860-a3b8hyyr	27	40	ATP	ATP	NNP
cord-006860-a3b8hyyr	27	41	and	and	CC
cord-006860-a3b8hyyr	27	42	ADP	ADP	NNP
cord-006860-a3b8hyyr	27	43	.	.	.
cord-006860-a3b8hyyr	28	1	Infusion	infusion	NN
cord-006860-a3b8hyyr	28	2	of	of	IN
cord-006860-a3b8hyyr	28	3	NO	no	DT
cord-006860-a3b8hyyr	28	4	-	-	HYPH
cord-006860-a3b8hyyr	28	5	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	28	6	in	in	IN
cord-006860-a3b8hyyr	28	7	vivo	vivo	NN
cord-006860-a3b8hyyr	28	8	leads	lead	VBZ
cord-006860-a3b8hyyr	28	9	to	to	IN
cord-006860-a3b8hyyr	28	10	vasoconstriction	vasoconstriction	NN
cord-006860-a3b8hyyr	28	11	and	and	CC
cord-006860-a3b8hyyr	28	12	increases	increase	NNS
cord-006860-a3b8hyyr	28	13	in	in	IN
cord-006860-a3b8hyyr	28	14	blood	blood	NN
cord-006860-a3b8hyyr	28	15	pressure	pressure	NN
cord-006860-a3b8hyyr	28	16	and	and	CC
cord-006860-a3b8hyyr	28	17	oral	oral	JJ
cord-006860-a3b8hyyr	28	18	administration	administration	NN
cord-006860-a3b8hyyr	28	19	to	to	TO
cord-006860-a3b8hyyr	28	20	hypertension	hypertension	NN
cord-006860-a3b8hyyr	28	21	in	in	IN
cord-006860-a3b8hyyr	28	22	the	the	DT
cord-006860-a3b8hyyr	28	23	rat	rat	NN
cord-006860-a3b8hyyr	28	24	.	.	.
cord-006860-a3b8hyyr	29	1	Within	within	IN
cord-006860-a3b8hyyr	29	2	the	the	DT
cord-006860-a3b8hyyr	29	3	endothelium	endothelium	NN
cord-006860-a3b8hyyr	29	4	,	,	,
cord-006860-a3b8hyyr	29	5	NO	no	RB
cord-006860-a3b8hyyr	29	6	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	29	7	ET	ET	NNP
cord-006860-a3b8hyyr	29	8	gene	gene	NN
cord-006860-a3b8hyyr	29	9	expression	expression	NN
cord-006860-a3b8hyyr	29	10	and	and	CC
cord-006860-a3b8hyyr	29	11	release	release	NN
cord-006860-a3b8hyyr	29	12	of	of	IN
cord-006860-a3b8hyyr	29	13	the	the	DT
cord-006860-a3b8hyyr	29	14	peptide	peptide	NN
cord-006860-a3b8hyyr	29	15	via	via	IN
cord-006860-a3b8hyyr	29	16	cGMP	cGMP	NNP
cord-006860-a3b8hyyr	29	17	.	.	.
cord-006860-a3b8hyyr	30	1	Hence	hence	RB
cord-006860-a3b8hyyr	30	2	,	,	,
cord-006860-a3b8hyyr	30	3	NO	no	RB
cord-006860-a3b8hyyr	30	4	-	-	HYPH
cord-006860-a3b8hyyr	30	5	induced	induce	VBN
cord-006860-a3b8hyyr	30	6	hypertension	hypertension	NN
cord-006860-a3b8hyyr	30	7	is	be	VBZ
cord-006860-a3b8hyyr	30	8	associated	associate	VBN
cord-006860-a3b8hyyr	30	9	with	with	IN
cord-006860-a3b8hyyr	30	10	increased	increase	VBN
cord-006860-a3b8hyyr	30	11	plasma	plasma	NN
cord-006860-a3b8hyyr	30	12	ET	ET	NNP
cord-006860-a3b8hyyr	30	13	levels	level	NNS
cord-006860-a3b8hyyr	30	14	.	.	.
cord-006860-a3b8hyyr	31	1	ET	ET	NNP
cord-006860-a3b8hyyr	31	2	,	,	,
cord-006860-a3b8hyyr	31	3	a	a	DT
cord-006860-a3b8hyyr	31	4	21-amino	21-amino	CD
cord-006860-a3b8hyyr	31	5	acid	acid	NN
cord-006860-a3b8hyyr	31	6	peptide	peptide	NN
cord-006860-a3b8hyyr	31	7	,	,	,
cord-006860-a3b8hyyr	31	8	has	have	VBZ
cord-006860-a3b8hyyr	31	9	potent	potent	JJ
cord-006860-a3b8hyyr	31	10	vasoconstrictor	vasoconstrictor	NN
cord-006860-a3b8hyyr	31	11	properties	property	NNS
cord-006860-a3b8hyyr	31	12	via	via	IN
cord-006860-a3b8hyyr	31	13	ETA	ETA	NNP
cord-006860-a3b8hyyr	31	14	-	-	:
cord-006860-a3b8hyyr	31	15	and	and	CC
cord-006860-a3b8hyyr	31	16	in	in	IN
cord-006860-a3b8hyyr	31	17	part	part	NN
cord-006860-a3b8hyyr	31	18	ETB	ETB	NNP
cord-006860-a3b8hyyr	31	19	-	-	HYPH
cord-006860-a3b8hyyr	31	20	raceptors	raceptor	NNS
cord-006860-a3b8hyyr	31	21	on	on	IN
cord-006860-a3b8hyyr	31	22	vascular	vascular	JJ
cord-006860-a3b8hyyr	31	23	smooth	smooth	JJ
cord-006860-a3b8hyyr	31	24	muscle	muscle	NN
cord-006860-a3b8hyyr	31	25	.	.	.
cord-006860-a3b8hyyr	32	1	In	in	IN
cord-006860-a3b8hyyr	32	2	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	32	3	cells	cell	NNS
cord-006860-a3b8hyyr	32	4	,	,	,
cord-006860-a3b8hyyr	32	5	ET	ET	NNP
cord-006860-a3b8hyyr	32	6	activates	activate	VBZ
cord-006860-a3b8hyyr	32	7	ETB	ETB	NNP
cord-006860-a3b8hyyr	32	8	-	-	HYPH
cord-006860-a3b8hyyr	32	9	receptors	receptor	NNS
cord-006860-a3b8hyyr	32	10	linked	link	VBN
cord-006860-a3b8hyyr	32	11	to	to	IN
cord-006860-a3b8hyyr	32	12	NO	NO	NNP
cord-006860-a3b8hyyr	32	13	and	and	CC
cord-006860-a3b8hyyr	32	14	prostacyclin	prostacyclin	JJ
cord-006860-a3b8hyyr	32	15	formation	formation	NN
cord-006860-a3b8hyyr	32	16	.	.	.
cord-006860-a3b8hyyr	33	1	Under	under	IN
cord-006860-a3b8hyyr	33	2	basal	basal	NN
cord-006860-a3b8hyyr	33	3	conditions	condition	NNS
cord-006860-a3b8hyyr	33	4	,	,	,
cord-006860-a3b8hyyr	33	5	little	little	JJ
cord-006860-a3b8hyyr	33	6	ET	ET	NNP
cord-006860-a3b8hyyr	33	7	is	be	VBZ
cord-006860-a3b8hyyr	33	8	formed	form	VBN
cord-006860-a3b8hyyr	33	9	,	,	,
cord-006860-a3b8hyyr	33	10	but	but	CC
cord-006860-a3b8hyyr	33	11	is	be	VBZ
cord-006860-a3b8hyyr	33	12	increased	increase	VBN
cord-006860-a3b8hyyr	33	13	by	by	IN
cord-006860-a3b8hyyr	33	14	thrombin	thrombin	NN
cord-006860-a3b8hyyr	33	15	,	,	,
cord-006860-a3b8hyyr	33	16	angiotensin	angiotensin	NN
cord-006860-a3b8hyyr	33	17	II	II	NNP
cord-006860-a3b8hyyr	33	18	,	,	,
cord-006860-a3b8hyyr	33	19	arginine	arginine	NN
cord-006860-a3b8hyyr	33	20	vasopressin	vasopressin	NN
cord-006860-a3b8hyyr	33	21	,	,	,
cord-006860-a3b8hyyr	33	22	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	33	23	and	and	CC
cord-006860-a3b8hyyr	33	24	ox	ox	JJ
cord-006860-a3b8hyyr	33	25	-	-	HYPH
cord-006860-a3b8hyyr	33	26	LDL	ldl	NN
cord-006860-a3b8hyyr	33	27	.	.	.
cord-006860-a3b8hyyr	34	1	ET	ET	NNP
cord-006860-a3b8hyyr	34	2	antagonists	antagonist	NNS
cord-006860-a3b8hyyr	34	3	have	have	VBP
cord-006860-a3b8hyyr	34	4	been	be	VBN
cord-006860-a3b8hyyr	34	5	developed	develop	VBN
cord-006860-a3b8hyyr	34	6	and	and	CC
cord-006860-a3b8hyyr	34	7	allow	allow	VB
cord-006860-a3b8hyyr	34	8	to	to	TO
cord-006860-a3b8hyyr	34	9	study	study	VB
cord-006860-a3b8hyyr	34	10	the	the	DT
cord-006860-a3b8hyyr	34	11	effects	effect	NNS
cord-006860-a3b8hyyr	34	12	of	of	IN
cord-006860-a3b8hyyr	34	13	ET	ET	NNP
cord-006860-a3b8hyyr	34	14	in	in	IN
cord-006860-a3b8hyyr	34	15	vivo	vivo	NN
cord-006860-a3b8hyyr	34	16	.	.	.
cord-006860-a3b8hyyr	35	1	ET	ET	NNP
cord-006860-a3b8hyyr	35	2	and	and	CC
cord-006860-a3b8hyyr	35	3	NO	no	DT
cord-006860-a3b8hyyr	35	4	most	most	RBS
cord-006860-a3b8hyyr	35	5	likely	likely	RB
cord-006860-a3b8hyyr	35	6	play	play	VBP
cord-006860-a3b8hyyr	35	7	an	an	DT
cord-006860-a3b8hyyr	35	8	important	important	JJ
cord-006860-a3b8hyyr	35	9	role	role	NN
cord-006860-a3b8hyyr	35	10	in	in	IN
cord-006860-a3b8hyyr	35	11	disease	disease	NN
cord-006860-a3b8hyyr	35	12	states	state	NNS
cord-006860-a3b8hyyr	35	13	such	such	JJ
cord-006860-a3b8hyyr	35	14	as	as	IN
cord-006860-a3b8hyyr	35	15	hypertension	hypertension	NN
cord-006860-a3b8hyyr	35	16	,	,	,
cord-006860-a3b8hyyr	35	17	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	35	18	,	,	,
cord-006860-a3b8hyyr	35	19	coronary	coronary	JJ
cord-006860-a3b8hyyr	35	20	artery	artery	NN
cord-006860-a3b8hyyr	35	21	disease	disease	NN
cord-006860-a3b8hyyr	35	22	,	,	,
cord-006860-a3b8hyyr	35	23	heart	heart	NN
cord-006860-a3b8hyyr	35	24	failure	failure	NN
cord-006860-a3b8hyyr	35	25	,	,	,
cord-006860-a3b8hyyr	35	26	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	35	27	hypertension	hypertension	NN
cord-006860-a3b8hyyr	35	28	and	and	CC
cord-006860-a3b8hyyr	35	29	subarachnoid	subarachnoid	NN
cord-006860-a3b8hyyr	35	30	hemorrhage	hemorrhage	NN
cord-006860-a3b8hyyr	35	31	.	.	.
cord-006860-a3b8hyyr	36	1	Clinical	clinical	JJ
cord-006860-a3b8hyyr	36	2	trials	trial	NNS
cord-006860-a3b8hyyr	36	3	to	to	TO
cord-006860-a3b8hyyr	36	4	further	further	RB
cord-006860-a3b8hyyr	36	5	define	define	VB
cord-006860-a3b8hyyr	36	6	their	-PRON-	PRP$
cord-006860-a3b8hyyr	36	7	role	role	NN
cord-006860-a3b8hyyr	36	8	in	in	IN
cord-006860-a3b8hyyr	36	9	these	these	DT
cord-006860-a3b8hyyr	36	10	disease	disease	NN
cord-006860-a3b8hyyr	36	11	states	state	NNS
cord-006860-a3b8hyyr	36	12	are	be	VBP
cord-006860-a3b8hyyr	36	13	now	now	RB
cord-006860-a3b8hyyr	36	14	under	under	IN
cord-006860-a3b8hyyr	36	15	way	way	NN
cord-006860-a3b8hyyr	36	16	.	.	.
cord-006860-a3b8hyyr	37	1	In	in	IN
cord-006860-a3b8hyyr	37	2	summary	summary	NN
cord-006860-a3b8hyyr	37	3	,	,	,
cord-006860-a3b8hyyr	37	4	the	the	DT
cord-006860-a3b8hyyr	37	5	endothelium	endothelium	NN
cord-006860-a3b8hyyr	37	6	is	be	VBZ
cord-006860-a3b8hyyr	37	7	an	an	DT
cord-006860-a3b8hyyr	37	8	important	important	JJ
cord-006860-a3b8hyyr	37	9	regulator	regulator	NN
cord-006860-a3b8hyyr	37	10	of	of	IN
cord-006860-a3b8hyyr	37	11	vascular	vascular	JJ
cord-006860-a3b8hyyr	37	12	tone	tone	NN
cord-006860-a3b8hyyr	37	13	and	and	CC
cord-006860-a3b8hyyr	37	14	structure	structure	NN
cord-006860-a3b8hyyr	37	15	in	in	IN
cord-006860-a3b8hyyr	37	16	vitro	vitro	FW
cord-006860-a3b8hyyr	37	17	and	and	CC
cord-006860-a3b8hyyr	37	18	in	in	IN
cord-006860-a3b8hyyr	37	19	vivo	vivo	NNP
cord-006860-a3b8hyyr	37	20	.	.	.
cord-006860-a3b8hyyr	38	1	In	in	IN
cord-006860-a3b8hyyr	38	2	disease	disease	NN
cord-006860-a3b8hyyr	38	3	states	state	NNS
cord-006860-a3b8hyyr	38	4	,	,	,
cord-006860-a3b8hyyr	38	5	their	-PRON-	PRP$
cord-006860-a3b8hyyr	38	6	interaction	interaction	NN
cord-006860-a3b8hyyr	38	7	is	be	VBZ
cord-006860-a3b8hyyr	38	8	imbalanced	imbalance	VBN
cord-006860-a3b8hyyr	38	9	leading	lead	VBG
cord-006860-a3b8hyyr	38	10	to	to	IN
cord-006860-a3b8hyyr	38	11	enhanced	enhanced	JJ
cord-006860-a3b8hyyr	38	12	vasoconstriction	vasoconstriction	NN
cord-006860-a3b8hyyr	38	13	,	,	,
cord-006860-a3b8hyyr	38	14	thrombus	thrombus	NN
cord-006860-a3b8hyyr	38	15	formation	formation	NN
cord-006860-a3b8hyyr	38	16	and	and	CC
cord-006860-a3b8hyyr	38	17	structural	structural	JJ
cord-006860-a3b8hyyr	38	18	changes	change	NNS
cord-006860-a3b8hyyr	38	19	of	of	IN
cord-006860-a3b8hyyr	38	20	the	the	DT
cord-006860-a3b8hyyr	38	21	blood	blood	NN
cord-006860-a3b8hyyr	38	22	vessel	vessel	NN
cord-006860-a3b8hyyr	38	23	wall	wall	NN
cord-006860-a3b8hyyr	38	24	.	.	.
cord-006860-a3b8hyyr	39	1	Pharmacological	pharmacological	JJ
cord-006860-a3b8hyyr	39	2	tools	tool	NNS
cord-006860-a3b8hyyr	39	3	aiming	aim	VBG
cord-006860-a3b8hyyr	39	4	to	to	TO
cord-006860-a3b8hyyr	39	5	inhibit	inhibit	VB
cord-006860-a3b8hyyr	39	6	those	those	DT
cord-006860-a3b8hyyr	39	7	changes	change	NNS
cord-006860-a3b8hyyr	39	8	are	be	VBP
cord-006860-a3b8hyyr	39	9	now	now	RB
cord-006860-a3b8hyyr	39	10	being	be	VBG
cord-006860-a3b8hyyr	39	11	developed	develop	VBN
cord-006860-a3b8hyyr	39	12	.	.	.
cord-006860-a3b8hyyr	40	1	J.M.	J.M.	NNP
cord-006860-a3b8hyyr	40	2	Harlan	Harlan	NNP
cord-006860-a3b8hyyr	40	3	,	,	,
cord-006860-a3b8hyyr	40	4	R.K.	R.K.	NNP
cord-006860-a3b8hyyr	40	5	W	W	NNP
cord-006860-a3b8hyyr	40	6	/	/	SYM
cord-006860-a3b8hyyr	40	7	nn	nn	UH
cord-006860-a3b8hyyr	40	8	,	,	,
cord-006860-a3b8hyyr	40	9	S.	S.	NNP
cord-006860-a3b8hyyr	40	10	Sharar	Sharar	NNP
cord-006860-a3b8hyyr	40	11	,	,	,
cord-006860-a3b8hyyr	40	12	and	and	CC
cord-006860-a3b8hyyr	40	13	N.	N.	NNP
cord-006860-a3b8hyyr	40	14	Vedder	Vedder	NNP
cord-006860-a3b8hyyr	40	15	Universit3	Universit3	NNP
cord-006860-a3b8hyyr	40	16	,	,	,
cord-006860-a3b8hyyr	40	17	of	of	IN
cord-006860-a3b8hyyr	40	18	Washington	Washington	NNP
cord-006860-a3b8hyyr	40	19	,	,	,
cord-006860-a3b8hyyr	40	20	Seattle	Seattle	NNP
cord-006860-a3b8hyyr	40	21	,	,	,
cord-006860-a3b8hyyr	40	22	Washington	Washington	NNP
cord-006860-a3b8hyyr	40	23	Ischemia	Ischemia	NNP
cord-006860-a3b8hyyr	40	24	-	-	HYPH
cord-006860-a3b8hyyr	40	25	reperfusion	reperfusion	NN
cord-006860-a3b8hyyr	40	26	injury	injury	NN
cord-006860-a3b8hyyr	40	27	has	have	VBZ
cord-006860-a3b8hyyr	40	28	been	be	VBN
cord-006860-a3b8hyyr	40	29	implicated	implicate	VBN
cord-006860-a3b8hyyr	40	30	in	in	IN
cord-006860-a3b8hyyr	40	31	the	the	DT
cord-006860-a3b8hyyr	40	32	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	40	33	of	of	IN
cord-006860-a3b8hyyr	40	34	a	a	DT
cord-006860-a3b8hyyr	40	35	wide	wide	JJ
cord-006860-a3b8hyyr	40	36	variety	variety	NN
cord-006860-a3b8hyyr	40	37	of	of	IN
cord-006860-a3b8hyyr	40	38	efinical	efinical	JJ
cord-006860-a3b8hyyr	40	39	disorders	disorder	NNS
cord-006860-a3b8hyyr	40	40	.	.	.
cord-006860-a3b8hyyr	41	1	[	[	-LRB-
cord-006860-a3b8hyyr	41	2	n	n	NNP
cord-006860-a3b8hyyr	41	3	preclinical	preclinical	JJ
cord-006860-a3b8hyyr	41	4	models	model	NNS
cord-006860-a3b8hyyr	41	5	,	,	,
cord-006860-a3b8hyyr	41	6	tissue	tissue	NN
cord-006860-a3b8hyyr	41	7	damage	damage	NN
cord-006860-a3b8hyyr	42	1	.clearly	.clearly	RB
cord-006860-a3b8hyyr	42	2	occurs	occur	VBZ
cord-006860-a3b8hyyr	42	3	during	during	IN
cord-006860-a3b8hyyr	42	4	ischemia	ischemia	NN
cord-006860-a3b8hyyr	42	5	,	,	,
cord-006860-a3b8hyyr	42	6	but	but	CC
cord-006860-a3b8hyyr	42	7	,	,	,
cord-006860-a3b8hyyr	42	8	parado	parado	FW
cord-006860-a3b8hyyr	42	9	.	.	.
cord-006860-a3b8hyyr	43	1	,	,	,
cord-006860-a3b8hyyr	43	2	dcally	dcally	RB
cord-006860-a3b8hyyr	43	3	,	,	,
cord-006860-a3b8hyyr	43	4	may	may	MD
cord-006860-a3b8hyyr	43	5	be	be	VB
cord-006860-a3b8hyyr	43	6	exacerbated	exacerbate	VBN
cord-006860-a3b8hyyr	43	7	during	during	IN
cord-006860-a3b8hyyr	43	8	reperfusion	reperfusion	NN
cord-006860-a3b8hyyr	43	9	.	.	.
cord-006860-a3b8hyyr	44	1	This	this	DT
cord-006860-a3b8hyyr	44	2	reperfusion	reperfusion	NN
cord-006860-a3b8hyyr	44	3	injury	injury	NN
cord-006860-a3b8hyyr	44	4	appears	appear	VBZ
cord-006860-a3b8hyyr	44	5	to	to	TO
cord-006860-a3b8hyyr	44	6	involve	involve	VB
cord-006860-a3b8hyyr	44	7	activation	activation	NN
cord-006860-a3b8hyyr	44	8	of	of	IN
cord-006860-a3b8hyyr	44	9	the	the	DT
cord-006860-a3b8hyyr	44	10	intlammato~	intlammato~	NNP
cord-006860-a3b8hyyr	44	11	,	,	,
cord-006860-a3b8hyyr	44	12	cascade	cascade	VB
cord-006860-a3b8hyyr	44	13	with	with	IN
cord-006860-a3b8hyyr	44	14	generation	generation	NN
cord-006860-a3b8hyyr	44	15	of	of	IN
cord-006860-a3b8hyyr	44	16	complement	complement	NN
cord-006860-a3b8hyyr	44	17	'	'	``
cord-006860-a3b8hyyr	44	18	components	component	NNS
cord-006860-a3b8hyyr	44	19	,	,	,
cord-006860-a3b8hyyr	44	20	lipoxygenase	lipoxygenase	NN
cord-006860-a3b8hyyr	44	21	products	product	NNS
cord-006860-a3b8hyyr	44	22	,	,	,
cord-006860-a3b8hyyr	44	23	and	and	CC
cord-006860-a3b8hyyr	44	24	chemokines	chemokine	NNS
cord-006860-a3b8hyyr	44	25	as	as	IN
cord-006860-a3b8hyyr	44	26	proximal	proximal	JJ
cord-006860-a3b8hyyr	44	27	mediators	mediator	NNS
cord-006860-a3b8hyyr	44	28	and	and	CC
cord-006860-a3b8hyyr	44	29	neutrophils	neutrophil	NNS
cord-006860-a3b8hyyr	44	30	as	as	IN
cord-006860-a3b8hyyr	44	31	final	final	JJ
cord-006860-a3b8hyyr	44	32	effectors	effector	NNS
cord-006860-a3b8hyyr	44	33	of	of	IN
cord-006860-a3b8hyyr	44	34	vascular	vascular	JJ
cord-006860-a3b8hyyr	44	35	and	and	CC
cord-006860-a3b8hyyr	44	36	tissue	tissue	NN
cord-006860-a3b8hyyr	44	37	damage	damage	NN
cord-006860-a3b8hyyr	44	38	.	.	.
cord-006860-a3b8hyyr	45	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	45	2	have	have	VBP
cord-006860-a3b8hyyr	45	3	examined	examine	VBN
cord-006860-a3b8hyyr	45	4	the	the	DT
cord-006860-a3b8hyyr	45	5	role	role	NN
cord-006860-a3b8hyyr	45	6	of	of	IN
cord-006860-a3b8hyyr	45	7	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	45	8	adhesion	adhesion	NN
cord-006860-a3b8hyyr	45	9	in	in	IN
cord-006860-a3b8hyyr	45	10	reperfusion	reperfusion	NN
cord-006860-a3b8hyyr	45	11	injury	injury	NN
cord-006860-a3b8hyyr	45	12	in	in	IN
cord-006860-a3b8hyyr	45	13	two	two	CD
cord-006860-a3b8hyyr	45	14	models	model	NNS
cord-006860-a3b8hyyr	45	15	-the	-the	ADD
cord-006860-a3b8hyyr	45	16	rabbit	rabbit	NN
cord-006860-a3b8hyyr	45	17	ear	ear	NN
cord-006860-a3b8hyyr	45	18	as	as	IN
cord-006860-a3b8hyyr	45	19	a	a	DT
cord-006860-a3b8hyyr	45	20	model	model	NN
cord-006860-a3b8hyyr	45	21	of	of	IN
cord-006860-a3b8hyyr	45	22	isolated	isolated	JJ
cord-006860-a3b8hyyr	45	23	organ	organ	NN
cord-006860-a3b8hyyr	45	24	injury	injury	NN
cord-006860-a3b8hyyr	45	25	and	and	CC
cord-006860-a3b8hyyr	45	26	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	45	27	shock	shock	NN
cord-006860-a3b8hyyr	45	28	and	and	CC
cord-006860-a3b8hyyr	45	29	resuscitation	resuscitation	NN
cord-006860-a3b8hyyr	45	30	in	in	IN
cord-006860-a3b8hyyr	45	31	the	the	DT
cord-006860-a3b8hyyr	45	32	rabbit	rabbit	NN
cord-006860-a3b8hyyr	45	33	and	and	CC
cord-006860-a3b8hyyr	45	34	primate	primate	NN
cord-006860-a3b8hyyr	45	35	as	as	IN
cord-006860-a3b8hyyr	45	36	a	a	DT
cord-006860-a3b8hyyr	45	37	model	model	NN
cord-006860-a3b8hyyr	45	38	of	of	IN
cord-006860-a3b8hyyr	45	39	traumatic	traumatic	JJ
cord-006860-a3b8hyyr	45	40	shock	shock	NN
cord-006860-a3b8hyyr	45	41	and	and	CC
cord-006860-a3b8hyyr	45	42	multiple	multiple	JJ
cord-006860-a3b8hyyr	45	43	organ	organ	NN
cord-006860-a3b8hyyr	45	44	failure	failure	NN
cord-006860-a3b8hyyr	45	45	.	.	.
cord-006860-a3b8hyyr	46	1	Data	datum	NNS
cord-006860-a3b8hyyr	46	2	regarding	regard	VBG
cord-006860-a3b8hyyr	46	3	the	the	DT
cord-006860-a3b8hyyr	46	4	efficacy	efficacy	NN
cord-006860-a3b8hyyr	46	5	,	,	,
cord-006860-a3b8hyyr	46	6	timing	timing	NN
cord-006860-a3b8hyyr	46	7	,	,	,
cord-006860-a3b8hyyr	46	8	and	and	CC
cord-006860-a3b8hyyr	46	9	safety	safety	NN
cord-006860-a3b8hyyr	46	10	of	of	IN
cord-006860-a3b8hyyr	46	11	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	46	12	adhesion	adhesion	NN
cord-006860-a3b8hyyr	46	13	blockade	blockade	NN
cord-006860-a3b8hyyr	46	14	using	use	VBG
cord-006860-a3b8hyyr	46	15	selectin	selectin	NNP
cord-006860-a3b8hyyr	46	16	-	-	:
cord-006860-a3b8hyyr	46	17	or	or	CC
cord-006860-a3b8hyyr	46	18	integrindirected	integrindirected	JJ
cord-006860-a3b8hyyr	46	19	reagents	reagent	NNS
cord-006860-a3b8hyyr	46	20	in	in	IN
cord-006860-a3b8hyyr	46	21	these	these	DT
cord-006860-a3b8hyyr	46	22	models	model	NNS
cord-006860-a3b8hyyr	46	23	w	w	IN
cord-006860-a3b8hyyr	46	24	/	/	SYM
cord-006860-a3b8hyyr	46	25	ll	ll	UH
cord-006860-a3b8hyyr	46	26	be	be	VB
cord-006860-a3b8hyyr	46	27	presented	present	VBN
cord-006860-a3b8hyyr	46	28	.	.	.
cord-006860-a3b8hyyr	47	1	The	the	DT
cord-006860-a3b8hyyr	47	2	current	current	JJ
cord-006860-a3b8hyyr	47	3	status	status	NN
cord-006860-a3b8hyyr	47	4	of	of	IN
cord-006860-a3b8hyyr	47	5	anti	anti	JJ
cord-006860-a3b8hyyr	47	6	-	-	JJ
cord-006860-a3b8hyyr	47	7	adhesion	adhesion	JJ
cord-006860-a3b8hyyr	47	8	therapy	therapy	NN
cord-006860-a3b8hyyr	47	9	in	in	IN
cord-006860-a3b8hyyr	47	10	other	other	JJ
cord-006860-a3b8hyyr	47	11	pre	pre	JJ
cord-006860-a3b8hyyr	47	12	-	-	JJ
cord-006860-a3b8hyyr	47	13	clinical	clinical	JJ
cord-006860-a3b8hyyr	47	14	models	model	NNS
cord-006860-a3b8hyyr	47	15	and	and	CC
cord-006860-a3b8hyyr	47	16	early	early	JJ
cord-006860-a3b8hyyr	47	17	clinical	clinical	JJ
cord-006860-a3b8hyyr	47	18	trials	trial	NNS
cord-006860-a3b8hyyr	47	19	will	will	MD
cord-006860-a3b8hyyr	47	20	be	be	VB
cord-006860-a3b8hyyr	47	21	re~4ewed	re~4ewe	VBN
cord-006860-a3b8hyyr	47	22	.	.	.
cord-006860-a3b8hyyr	48	1	An	an	DT
cord-006860-a3b8hyyr	48	2	amidolytic	amidolytic	JJ
cord-006860-a3b8hyyr	48	3	assay	assay	NN
cord-006860-a3b8hyyr	48	4	for	for	IN
cord-006860-a3b8hyyr	48	5	the	the	DT
cord-006860-a3b8hyyr	48	6	determination	determination	NN
cord-006860-a3b8hyyr	48	7	of	of	IN
cord-006860-a3b8hyyr	48	8	activated	activate	VBN
cord-006860-a3b8hyyr	48	9	protein	protein	NN
cord-006860-a3b8hyyr	48	10	C	C	NNP
cord-006860-a3b8hyyr	48	11	(	(	-LRB-
cord-006860-a3b8hyyr	48	12	APC)-resistant	apc)-resistant	JJ
cord-006860-a3b8hyyr	48	13	factor	factor	NN
cord-006860-a3b8hyyr	48	14	Va	Va	NNP
cord-006860-a3b8hyyr	48	15	(	(	-LRB-
cord-006860-a3b8hyyr	48	16	FVa	FVa	NNP
cord-006860-a3b8hyyr	48	17	)	)	-RRB-
cord-006860-a3b8hyyr	48	18	has	have	VBZ
cord-006860-a3b8hyyr	48	19	been	be	VBN
cord-006860-a3b8hyyr	48	20	developed	develop	VBN
cord-006860-a3b8hyyr	48	21	.	.	.
cord-006860-a3b8hyyr	49	1	This	this	DT
cord-006860-a3b8hyyr	49	2	assay	assay	NN
cord-006860-a3b8hyyr	49	3	measures	measure	VBZ
cord-006860-a3b8hyyr	49	4	the	the	DT
cord-006860-a3b8hyyr	49	5	cofactor	cofactor	NN
cord-006860-a3b8hyyr	49	6	activity	activity	NN
cord-006860-a3b8hyyr	49	7	of	of	IN
cord-006860-a3b8hyyr	49	8	FVa	FVa	NNS
cord-006860-a3b8hyyr	49	9	in	in	IN
cord-006860-a3b8hyyr	49	10	diluted	diluted	JJ
cord-006860-a3b8hyyr	49	11	plasma	plasma	NN
cord-006860-a3b8hyyr	49	12	samples	sample	NNS
cord-006860-a3b8hyyr	49	13	via	via	IN
cord-006860-a3b8hyyr	49	14	the	the	DT
cord-006860-a3b8hyyr	49	15	rate	rate	NN
cord-006860-a3b8hyyr	49	16	of	of	IN
cord-006860-a3b8hyyr	49	17	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	49	18	formation	formation	NN
cord-006860-a3b8hyyr	49	19	.	.	.
cord-006860-a3b8hyyr	50	1	The	the	DT
cord-006860-a3b8hyyr	50	2	APC	APC	NNP
cord-006860-a3b8hyyr	50	3	response	response	NN
cord-006860-a3b8hyyr	50	4	is	be	VBZ
cord-006860-a3b8hyyr	50	5	calculated	calculate	VBN
cord-006860-a3b8hyyr	50	6	from	from	IN
cord-006860-a3b8hyyr	50	7	two	two	CD
cord-006860-a3b8hyyr	50	8	FV	FV	NNP
cord-006860-a3b8hyyr	50	9	determinations	determination	NNS
cord-006860-a3b8hyyr	50	10	:	:	:
cord-006860-a3b8hyyr	50	11	one	one	CD
cord-006860-a3b8hyyr	50	12	performed	perform	VBN
cord-006860-a3b8hyyr	50	13	in	in	IN
cord-006860-a3b8hyyr	50	14	the	the	DT
cord-006860-a3b8hyyr	50	15	presence	presence	NN
cord-006860-a3b8hyyr	50	16	(	(	-LRB-
cord-006860-a3b8hyyr	50	17	APC	APC	NNP
cord-006860-a3b8hyyr	50	18	-	-	HYPH
cord-006860-a3b8hyyr	50	19	FV	FV	NNP
cord-006860-a3b8hyyr	50	20	)	)	-RRB-
cord-006860-a3b8hyyr	50	21	and	and	CC
cord-006860-a3b8hyyr	50	22	one	one	CD
cord-006860-a3b8hyyr	50	23	in	in	IN
cord-006860-a3b8hyyr	50	24	the	the	DT
cord-006860-a3b8hyyr	50	25	absence	absence	NN
cord-006860-a3b8hyyr	50	26	of	of	IN
cord-006860-a3b8hyyr	50	27	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	50	28	APC	APC	NNP
cord-006860-a3b8hyyr	50	29	.	.	.
cord-006860-a3b8hyyr	51	1	The	the	DT
cord-006860-a3b8hyyr	51	2	APC	APC	NNP
cord-006860-a3b8hyyr	51	3	-	-	HYPH
cord-006860-a3b8hyyr	51	4	FV	fv	NN
cord-006860-a3b8hyyr	51	5	activity	activity	NN
cord-006860-a3b8hyyr	51	6	is	be	VBZ
cord-006860-a3b8hyyr	51	7	expressed	express	VBN
cord-006860-a3b8hyyr	51	8	as	as	IN
cord-006860-a3b8hyyr	51	9	percentage	percentage	NN
cord-006860-a3b8hyyr	51	10	of	of	IN
cord-006860-a3b8hyyr	51	11	the	the	DT
cord-006860-a3b8hyyr	51	12	initial	initial	JJ
cord-006860-a3b8hyyr	51	13	FV	fv	NN
cord-006860-a3b8hyyr	51	14	activity	activity	NN
cord-006860-a3b8hyyr	51	15	and	and	CC
cord-006860-a3b8hyyr	51	16	indicates	indicate	VBZ
cord-006860-a3b8hyyr	51	17	the	the	DT
cord-006860-a3b8hyyr	51	18	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	51	19	of	of	IN
cord-006860-a3b8hyyr	51	20	FVa	FVa	NNS
cord-006860-a3b8hyyr	51	21	to	to	IN
cord-006860-a3b8hyyr	51	22	APC	APC	NNP
cord-006860-a3b8hyyr	51	23	.	.	.
cord-006860-a3b8hyyr	52	1	Normal	normal	JJ
cord-006860-a3b8hyyr	52	2	ranges	range	NNS
cord-006860-a3b8hyyr	52	3	were	be	VBD
cord-006860-a3b8hyyr	52	4	established	establish	VBN
cord-006860-a3b8hyyr	52	5	by	by	IN
cord-006860-a3b8hyyr	52	6	analysing	analyse	VBG
cord-006860-a3b8hyyr	52	7	plasma	plasma	NN
cord-006860-a3b8hyyr	52	8	samples	sample	NNS
cord-006860-a3b8hyyr	52	9	of	of	IN
cord-006860-a3b8hyyr	52	10	100	100	CD
cord-006860-a3b8hyyr	52	11	healthy	healthy	JJ
cord-006860-a3b8hyyr	52	12	individuals	individual	NNS
cord-006860-a3b8hyyr	52	13	and	and	CC
cord-006860-a3b8hyyr	52	14	an	an	DT
cord-006860-a3b8hyyr	52	15	APC	APC	NNP
cord-006860-a3b8hyyr	52	16	-	-	HYPH
cord-006860-a3b8hyyr	52	17	FV	fv	NN
cord-006860-a3b8hyyr	52	18	activity	activity	NN
cord-006860-a3b8hyyr	52	19	above	above	IN
cord-006860-a3b8hyyr	52	20	60	60	CD
cord-006860-a3b8hyyr	52	21	%	%	NN
cord-006860-a3b8hyyr	52	22	was	be	VBD
cord-006860-a3b8hyyr	52	23	found	find	VBN
cord-006860-a3b8hyyr	52	24	to	to	TO
cord-006860-a3b8hyyr	52	25	be	be	VB
cord-006860-a3b8hyyr	52	26	indicative	indicative	JJ
cord-006860-a3b8hyyr	52	27	for	for	IN
cord-006860-a3b8hyyr	52	28	APC	APC	NNP
cord-006860-a3b8hyyr	52	29	-	-	HYPH
cord-006860-a3b8hyyr	52	30	resistance	resistance	NN
cord-006860-a3b8hyyr	52	31	(	(	-LRB-
cord-006860-a3b8hyyr	52	32	APC	APC	NNP
cord-006860-a3b8hyyr	52	33	-	-	HYPH
cord-006860-a3b8hyyr	52	34	R	R	NNP
cord-006860-a3b8hyyr	52	35	)	)	-RRB-
cord-006860-a3b8hyyr	52	36	.	.	.
cord-006860-a3b8hyyr	53	1	In	in	IN
cord-006860-a3b8hyyr	53	2	a	a	DT
cord-006860-a3b8hyyr	53	3	control	control	NN
cord-006860-a3b8hyyr	53	4	group	group	NN
cord-006860-a3b8hyyr	53	5	of	of	IN
cord-006860-a3b8hyyr	53	6	34	34	CD
cord-006860-a3b8hyyr	53	7	patients	patient	NNS
cord-006860-a3b8hyyr	53	8	the	the	DT
cord-006860-a3b8hyyr	53	9	APC	APC	NNP
cord-006860-a3b8hyyr	53	10	-	-	HYPH
cord-006860-a3b8hyyr	53	11	R	r	NN
cord-006860-a3b8hyyr	53	12	assay	assay	NN
cord-006860-a3b8hyyr	53	13	gave	give	VBD
cord-006860-a3b8hyyr	53	14	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	53	15	results	result	NNS
cord-006860-a3b8hyyr	53	16	in	in	IN
cord-006860-a3b8hyyr	53	17	15	15	CD
cord-006860-a3b8hyyr	53	18	patients	patient	NNS
cord-006860-a3b8hyyr	53	19	.	.	.
cord-006860-a3b8hyyr	54	1	DNA	DNA	NNP
cord-006860-a3b8hyyr	54	2	analysis	analysis	NN
cord-006860-a3b8hyyr	54	3	confirmed	confirm	VBD
cord-006860-a3b8hyyr	54	4	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	54	5	FV	FV	NNP
cord-006860-a3b8hyyr	54	6	R506Q	R506Q	NNP
cord-006860-a3b8hyyr	54	7	mutation	mutation	NN
cord-006860-a3b8hyyr	54	8	in	in	IN
cord-006860-a3b8hyyr	54	9	all	all	DT
cord-006860-a3b8hyyr	54	10	15	15	CD
cord-006860-a3b8hyyr	54	11	patients	patient	NNS
cord-006860-a3b8hyyr	54	12	and	and	CC
cord-006860-a3b8hyyr	54	13	confirmed	confirm	VBD
cord-006860-a3b8hyyr	54	14	the	the	DT
cord-006860-a3b8hyyr	54	15	non	non	JJ
cord-006860-a3b8hyyr	54	16	-	-	JJ
cord-006860-a3b8hyyr	54	17	carrier	carrier	JJ
cord-006860-a3b8hyyr	54	18	status	status	NN
cord-006860-a3b8hyyr	54	19	in	in	IN
cord-006860-a3b8hyyr	54	20	all	all	DT
cord-006860-a3b8hyyr	54	21	of	of	IN
cord-006860-a3b8hyyr	54	22	the	the	DT
cord-006860-a3b8hyyr	54	23	19	19	CD
cord-006860-a3b8hyyr	54	24	patients	patient	NNS
cord-006860-a3b8hyyr	54	25	yielding	yield	VBG
cord-006860-a3b8hyyr	54	26	normal	normal	JJ
cord-006860-a3b8hyyr	54	27	results	result	NNS
cord-006860-a3b8hyyr	54	28	.	.	.
cord-006860-a3b8hyyr	55	1	An	an	DT
cord-006860-a3b8hyyr	55	2	aPTT	aptt	NN
cord-006860-a3b8hyyr	55	3	-	-	HYPH
cord-006860-a3b8hyyr	55	4	based	base	VBN
cord-006860-a3b8hyyr	55	5	APC	APC	NNP
cord-006860-a3b8hyyr	55	6	-	-	HYPH
cord-006860-a3b8hyyr	55	7	R	r	NN
cord-006860-a3b8hyyr	55	8	assay	assay	NN
cord-006860-a3b8hyyr	55	9	performed	perform	VBN
cord-006860-a3b8hyyr	55	10	on	on	IN
cord-006860-a3b8hyyr	55	11	the	the	DT
cord-006860-a3b8hyyr	55	12	same	same	JJ
cord-006860-a3b8hyyr	55	13	group	group	NN
cord-006860-a3b8hyyr	55	14	of	of	IN
cord-006860-a3b8hyyr	55	15	patients	patient	NNS
cord-006860-a3b8hyyr	55	16	showed	show	VBD
cord-006860-a3b8hyyr	55	17	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	55	18	results	result	NNS
cord-006860-a3b8hyyr	55	19	in	in	IN
cord-006860-a3b8hyyr	55	20	two	two	CD
cord-006860-a3b8hyyr	55	21	of	of	IN
cord-006860-a3b8hyyr	55	22	the	the	DT
cord-006860-a3b8hyyr	55	23	non	non	JJ
cord-006860-a3b8hyyr	55	24	-	-	JJ
cord-006860-a3b8hyyr	55	25	carrier	carrier	JJ
cord-006860-a3b8hyyr	55	26	patients	patient	NNS
cord-006860-a3b8hyyr	55	27	.	.	.
cord-006860-a3b8hyyr	56	1	One	one	CD
cord-006860-a3b8hyyr	56	2	of	of	IN
cord-006860-a3b8hyyr	56	3	these	these	DT
cord-006860-a3b8hyyr	56	4	patients	patient	NNS
cord-006860-a3b8hyyr	56	5	was	be	VBD
cord-006860-a3b8hyyr	56	6	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	56	7	as	as	IN
cord-006860-a3b8hyyr	56	8	positive	positive	JJ
cord-006860-a3b8hyyr	56	9	for	for	IN
cord-006860-a3b8hyyr	56	10	lupus	lupus	NN
cord-006860-a3b8hyyr	56	11	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	56	12	,	,	,
cord-006860-a3b8hyyr	56	13	whereas	whereas	IN
cord-006860-a3b8hyyr	56	14	the	the	DT
cord-006860-a3b8hyyr	56	15	reason	reason	NN
cord-006860-a3b8hyyr	56	16	for	for	IN
cord-006860-a3b8hyyr	56	17	the	the	DT
cord-006860-a3b8hyyr	56	18	wrong	wrong	JJ
cord-006860-a3b8hyyr	56	19	positive	positive	JJ
cord-006860-a3b8hyyr	56	20	result	result	NN
cord-006860-a3b8hyyr	56	21	in	in	IN
cord-006860-a3b8hyyr	56	22	the	the	DT
cord-006860-a3b8hyyr	56	23	second	second	JJ
cord-006860-a3b8hyyr	56	24	patient	patient	NN
cord-006860-a3b8hyyr	56	25	remains	remain	VBZ
cord-006860-a3b8hyyr	56	26	unclear	unclear	JJ
cord-006860-a3b8hyyr	56	27	.	.	.
cord-006860-a3b8hyyr	57	1	Eleven	eleven	CD
cord-006860-a3b8hyyr	57	2	patients	patient	NNS
cord-006860-a3b8hyyr	57	3	were	be	VBD
cord-006860-a3b8hyyr	57	4	analyzed	analyze	VBN
cord-006860-a3b8hyyr	57	5	before	before	IN
cord-006860-a3b8hyyr	57	6	start	start	NN
cord-006860-a3b8hyyr	57	7	of	of	IN
cord-006860-a3b8hyyr	57	8	oral	oral	JJ
cord-006860-a3b8hyyr	57	9	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	57	10	and	and	CC
cord-006860-a3b8hyyr	57	11	during	during	IN
cord-006860-a3b8hyyr	57	12	oral	oral	JJ
cord-006860-a3b8hyyr	57	13	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	57	14	treatment	treatment	NN
cord-006860-a3b8hyyr	57	15	.	.	.
cord-006860-a3b8hyyr	58	1	Comparison	comparison	NN
cord-006860-a3b8hyyr	58	2	of	of	IN
cord-006860-a3b8hyyr	58	3	the	the	DT
cord-006860-a3b8hyyr	58	4	assay	assay	NN
cord-006860-a3b8hyyr	58	5	results	result	NNS
cord-006860-a3b8hyyr	58	6	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	58	7	a	a	DT
cord-006860-a3b8hyyr	58	8	correlation	correlation	NN
cord-006860-a3b8hyyr	58	9	of	of	IN
cord-006860-a3b8hyyr	58	10	96	96	CD
cord-006860-a3b8hyyr	58	11	%	%	NN
cord-006860-a3b8hyyr	58	12	indicating	indicate	VBG
cord-006860-a3b8hyyr	58	13	that	that	IN
cord-006860-a3b8hyyr	58	14	the	the	DT
cord-006860-a3b8hyyr	58	15	assay	assay	NN
cord-006860-a3b8hyyr	58	16	is	be	VBZ
cord-006860-a3b8hyyr	58	17	independent	independent	JJ
cord-006860-a3b8hyyr	58	18	of	of	IN
cord-006860-a3b8hyyr	58	19	the	the	DT
cord-006860-a3b8hyyr	58	20	activities	activity	NNS
cord-006860-a3b8hyyr	58	21	of	of	IN
cord-006860-a3b8hyyr	58	22	vitamin	vitamin	NN
cord-006860-a3b8hyyr	58	23	K	k	NN
cord-006860-a3b8hyyr	58	24	-	-	HYPH
cord-006860-a3b8hyyr	58	25	dependent	dependent	JJ
cord-006860-a3b8hyyr	58	26	clotting	clotting	NN
cord-006860-a3b8hyyr	58	27	factors	factor	NNS
cord-006860-a3b8hyyr	58	28	.	.	.
cord-006860-a3b8hyyr	59	1	The	the	DT
cord-006860-a3b8hyyr	59	2	APC	APC	NNP
cord-006860-a3b8hyyr	59	3	-	-	HYPH
cord-006860-a3b8hyyr	59	4	R	R	NNP
cord-006860-a3b8hyyr	59	5	amidolytic	amidolytic	NNP
cord-006860-a3b8hyyr	59	6	assays	assay	NNS
cord-006860-a3b8hyyr	59	7	allows	allow	VBZ
cord-006860-a3b8hyyr	59	8	specific	specific	JJ
cord-006860-a3b8hyyr	59	9	and	and	CC
cord-006860-a3b8hyyr	59	10	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	59	11	detection	detection	NN
cord-006860-a3b8hyyr	59	12	of	of	IN
cord-006860-a3b8hyyr	59	13	FVa	FVa	NNS
cord-006860-a3b8hyyr	59	14	-	-	:
cord-006860-a3b8hyyr	59	15	resistant	resistant	JJ
cord-006860-a3b8hyyr	59	16	to	to	IN
cord-006860-a3b8hyyr	59	17	APC	APC	NNP
cord-006860-a3b8hyyr	59	18	.	.	.
cord-006860-a3b8hyyr	60	1	The	the	DT
cord-006860-a3b8hyyr	60	2	assay	assay	NN
cord-006860-a3b8hyyr	60	3	is	be	VBZ
cord-006860-a3b8hyyr	60	4	performable	performable	JJ
cord-006860-a3b8hyyr	60	5	in	in	IN
cord-006860-a3b8hyyr	60	6	plasma	plasma	NN
cord-006860-a3b8hyyr	60	7	samples	sample	NNS
cord-006860-a3b8hyyr	60	8	of	of	IN
cord-006860-a3b8hyyr	60	9	all	all	DT
cord-006860-a3b8hyyr	60	10	persons	person	NNS
cord-006860-a3b8hyyr	60	11	in	in	IN
cord-006860-a3b8hyyr	60	12	whom	whom	WP
cord-006860-a3b8hyyr	60	13	the	the	DT
cord-006860-a3b8hyyr	60	14	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	60	15	of	of	IN
cord-006860-a3b8hyyr	60	16	APC	APC	NNP
cord-006860-a3b8hyyr	60	17	-	-	HYPH
cord-006860-a3b8hyyr	60	18	R	R	NNP
cord-006860-a3b8hyyr	60	19	may	may	MD
cord-006860-a3b8hyyr	60	20	be	be	VB
cord-006860-a3b8hyyr	60	21	indicated	indicate	VBN
cord-006860-a3b8hyyr	60	22	.	.	.
cord-006860-a3b8hyyr	61	1	In	in	IN
cord-006860-a3b8hyyr	61	2	patients	patient	NNS
cord-006860-a3b8hyyr	61	3	treated	treat	VBN
cord-006860-a3b8hyyr	61	4	with	with	IN
cord-006860-a3b8hyyr	61	5	oral	oral	JJ
cord-006860-a3b8hyyr	61	6	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	61	7	or	or	CC
cord-006860-a3b8hyyr	61	8	showing	show	VBG
cord-006860-a3b8hyyr	61	9	other	other	JJ
cord-006860-a3b8hyyr	61	10	clotting	clotting	NN
cord-006860-a3b8hyyr	61	11	abnormalities	abnormality	NNS
cord-006860-a3b8hyyr	61	12	affecting	affect	VBG
cord-006860-a3b8hyyr	61	13	the	the	DT
cord-006860-a3b8hyyr	61	14	aPTT	aptt	NN
cord-006860-a3b8hyyr	62	1	the	the	DT
cord-006860-a3b8hyyr	62	2	APC	APC	NNP
cord-006860-a3b8hyyr	62	3	-	-	HYPH
cord-006860-a3b8hyyr	62	4	R	R	NNP
cord-006860-a3b8hyyr	62	5	amidolytic	amidolytic	JJ
cord-006860-a3b8hyyr	62	6	assay	assay	NN
cord-006860-a3b8hyyr	62	7	is	be	VBZ
cord-006860-a3b8hyyr	62	8	helpful	helpful	JJ
cord-006860-a3b8hyyr	62	9	to	to	TO
cord-006860-a3b8hyyr	62	10	establish	establish	VB
cord-006860-a3b8hyyr	62	11	the	the	DT
cord-006860-a3b8hyyr	62	12	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	62	13	of	of	IN
cord-006860-a3b8hyyr	62	14	APC	APC	NNP
cord-006860-a3b8hyyr	62	15	-	-	HYPH
cord-006860-a3b8hyyr	62	16	R.	R.	NNP
cord-006860-a3b8hyyr	62	17	Dept	Dept	NNP
cord-006860-a3b8hyyr	62	18	of	of	IN
cord-006860-a3b8hyyr	62	19	Pediatrics	Pediatrics	NNP
cord-006860-a3b8hyyr	62	20	,	,	,
cord-006860-a3b8hyyr	62	21	University	University	NNP
cord-006860-a3b8hyyr	62	22	Hospitals	Hospitals	NNPS
cord-006860-a3b8hyyr	62	23	Kiel	Kiel	NNP
cord-006860-a3b8hyyr	62	24	and	and	CC
cord-006860-a3b8hyyr	62	25	Mtinster	Mtinster	NNP
cord-006860-a3b8hyyr	62	26	,	,	,
cord-006860-a3b8hyyr	62	27	Germany	Germany	NNP
cord-006860-a3b8hyyr	62	28	Resistance	Resistance	NNP
cord-006860-a3b8hyyr	62	29	to	to	IN
cord-006860-a3b8hyyr	62	30	activated	activate	VBN
cord-006860-a3b8hyyr	62	31	protein	protein	NN
cord-006860-a3b8hyyr	62	32	C	c	NN
cord-006860-a3b8hyyr	62	33	(	(	-LRB-
cord-006860-a3b8hyyr	62	34	APCR	APCR	NNP
cord-006860-a3b8hyyr	62	35	)	)	-RRB-
cord-006860-a3b8hyyr	62	36	,	,	,
cord-006860-a3b8hyyr	62	37	in	in	IN
cord-006860-a3b8hyyr	62	38	the	the	DT
cord-006860-a3b8hyyr	62	39	majority	majority	NN
cord-006860-a3b8hyyr	62	40	of	of	IN
cord-006860-a3b8hyyr	62	41	cases	case	NNS
cord-006860-a3b8hyyr	62	42	associated	associate	VBN
cord-006860-a3b8hyyr	62	43	with	with	IN
cord-006860-a3b8hyyr	62	44	the	the	DT
cord-006860-a3b8hyyr	62	45	Arg	Arg	NNP
cord-006860-a3b8hyyr	62	46	506	506	CD
cord-006860-a3b8hyyr	62	47	Gin	Gin	NNP
cord-006860-a3b8hyyr	62	48	point	point	NN
cord-006860-a3b8hyyr	62	49	mutation	mutation	NN
cord-006860-a3b8hyyr	62	50	in	in	IN
cord-006860-a3b8hyyr	62	51	the	the	DT
cord-006860-a3b8hyyr	62	52	factor	factor	NN
cord-006860-a3b8hyyr	62	53	V	v	NN
cord-006860-a3b8hyyr	62	54	gene	gene	NN
cord-006860-a3b8hyyr	62	55	is	be	VBZ
cord-006860-a3b8hyyr	62	56	present	present	JJ
cord-006860-a3b8hyyr	62	57	in	in	IN
cord-006860-a3b8hyyr	62	58	more	more	JJR
cord-006860-a3b8hyyr	62	59	than	than	IN
cord-006860-a3b8hyyr	62	60	50	50	CD
cord-006860-a3b8hyyr	62	61	%	%	NN
cord-006860-a3b8hyyr	62	62	of	of	IN
cord-006860-a3b8hyyr	62	63	patients	patient	NNS
cord-006860-a3b8hyyr	62	64	<	<	XX
cord-006860-a3b8hyyr	62	65	60	60	CD
cord-006860-a3b8hyyr	62	66	years	year	NNS
cord-006860-a3b8hyyr	62	67	of	of	IN
cord-006860-a3b8hyyr	62	68	age	age	NN
cord-006860-a3b8hyyr	62	69	with	with	IN
cord-006860-a3b8hyyr	62	70	unexplained	unexplained	JJ
cord-006860-a3b8hyyr	62	71	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	62	72	.	.	.
cord-006860-a3b8hyyr	63	1	To	to	TO
cord-006860-a3b8hyyr	63	2	determine	determine	VB
cord-006860-a3b8hyyr	63	3	to	to	IN
cord-006860-a3b8hyyr	63	4	what	what	WP
cord-006860-a3b8hyyr	63	5	exteut	exteut	NN
cord-006860-a3b8hyyr	63	6	this	this	DT
cord-006860-a3b8hyyr	63	7	relativdy	relativdy	NNP
cord-006860-a3b8hyyr	63	8	common	common	JJ
cord-006860-a3b8hyyr	63	9	gene	gene	NN
cord-006860-a3b8hyyr	63	10	mutation	mutation	NN
cord-006860-a3b8hyyr	63	11	affects	affect	VBZ
cord-006860-a3b8hyyr	63	12	the	the	DT
cord-006860-a3b8hyyr	63	13	risk	risk	NN
cord-006860-a3b8hyyr	63	14	of	of	IN
cord-006860-a3b8hyyr	63	15	thromboembolie	thromboembolie	NNP
cord-006860-a3b8hyyr	63	16	events	event	NNS
cord-006860-a3b8hyyr	63	17	in	in	IN
cord-006860-a3b8hyyr	63	18	infants	infant	NNS
cord-006860-a3b8hyyr	63	19	and	and	CC
cord-006860-a3b8hyyr	63	20	children	child	NNS
cord-006860-a3b8hyyr	63	21	,	,	,
cord-006860-a3b8hyyr	63	22	its	-PRON-	PRP$
cord-006860-a3b8hyyr	63	23	occurrence	occurrence	NN
cord-006860-a3b8hyyr	63	24	was	be	VBD
cord-006860-a3b8hyyr	63	25	investigated	investigate	VBN
cord-006860-a3b8hyyr	63	26	in	in	IN
cord-006860-a3b8hyyr	63	27	a	a	DT
cord-006860-a3b8hyyr	63	28	population	population	NN
cord-006860-a3b8hyyr	63	29	of	of	IN
cord-006860-a3b8hyyr	63	30	children	child	NNS
cord-006860-a3b8hyyr	63	31	with	with	IN
cord-006860-a3b8hyyr	63	32	unexplained	unexplained	JJ
cord-006860-a3b8hyyr	63	33	venous	venous	JJ
cord-006860-a3b8hyyr	63	34	or	or	CC
cord-006860-a3b8hyyr	63	35	arterial	arterial	JJ
cord-006860-a3b8hyyr	63	36	thromboernbotism	thromboernbotism	NN
cord-006860-a3b8hyyr	63	37	:	:	:
cord-006860-a3b8hyyr	63	38	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	63	39	of	of	IN
cord-006860-a3b8hyyr	63	40	the	the	DT
cord-006860-a3b8hyyr	63	41	central	central	JJ
cord-006860-a3b8hyyr	63	42	nervous	nervous	JJ
cord-006860-a3b8hyyr	63	43	system	system	NN
cord-006860-a3b8hyyr	63	44	(	(	-LRB-
cord-006860-a3b8hyyr	63	45	CNS	CNS	NNP
cord-006860-a3b8hyyr	63	46	,	,	,
cord-006860-a3b8hyyr	63	47	n=4	n=4	JJ
cord-006860-a3b8hyyr	63	48	)	)	-RRB-
cord-006860-a3b8hyyr	63	49	,	,	,
cord-006860-a3b8hyyr	63	50	vena	vena	NNP
cord-006860-a3b8hyyr	63	51	portae	portae	NNP
cord-006860-a3b8hyyr	63	52	(	(	-LRB-
cord-006860-a3b8hyyr	63	53	n=4	n=4	NNP
cord-006860-a3b8hyyr	63	54	)	)	-RRB-
cord-006860-a3b8hyyr	63	55	,	,	,
cord-006860-a3b8hyyr	63	56	deep	deep	JJ
cord-006860-a3b8hyyr	63	57	vein	vein	NN
cord-006860-a3b8hyyr	63	58	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	63	59	(	(	-LRB-
cord-006860-a3b8hyyr	63	60	n=4	n=4	NNP
cord-006860-a3b8hyyr	63	61	)	)	-RRB-
cord-006860-a3b8hyyr	63	62	,	,	,
cord-006860-a3b8hyyr	63	63	vena	vena	NNP
cord-006860-a3b8hyyr	63	64	caval	caval	NNP
cord-006860-a3b8hyyr	63	65	occlusion	occlusion	NN
cord-006860-a3b8hyyr	63	66	(	(	-LRB-
cord-006860-a3b8hyyr	63	67	n=4	n=4	NNP
cord-006860-a3b8hyyr	63	68	)	)	-RRB-
cord-006860-a3b8hyyr	63	69	,	,	,
cord-006860-a3b8hyyr	63	70	neonatal	neonatal	JJ
cord-006860-a3b8hyyr	63	71	renal	renal	JJ
cord-006860-a3b8hyyr	63	72	venous	venous	JJ
cord-006860-a3b8hyyr	63	73	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	63	74	(	(	-LRB-
cord-006860-a3b8hyyr	63	75	RVI	RVI	NNP
cord-006860-a3b8hyyr	63	76	'	'	''
cord-006860-a3b8hyyr	63	77	;	;	:
cord-006860-a3b8hyyr	63	78	n--3	n--3	NNP
cord-006860-a3b8hyyr	63	79	)	)	-RRB-
cord-006860-a3b8hyyr	63	80	,	,	,
cord-006860-a3b8hyyr	63	81	neonatal	neonatal	JJ
cord-006860-a3b8hyyr	63	82	stroke	stroke	NN
cord-006860-a3b8hyyr	63	83	(	(	-LRB-
cord-006860-a3b8hyyr	63	84	n=14	n=14	NNP
cord-006860-a3b8hyyr	63	85	)	)	-RRB-
cord-006860-a3b8hyyr	63	86	,	,	,
cord-006860-a3b8hyyr	63	87	stroke	stroke	NN
cord-006860-a3b8hyyr	63	88	(	(	-LRB-
cord-006860-a3b8hyyr	63	89	n=3	n=3	NN
cord-006860-a3b8hyyr	63	90	)	)	-RRB-
cord-006860-a3b8hyyr	63	91	,	,	,
cord-006860-a3b8hyyr	63	92	arteria	arteria	NNP
cord-006860-a3b8hyyr	63	93	femoralis	femoralis	NNP
cord-006860-a3b8hyyr	63	94	ocdusion	ocdusion	NNP
cord-006860-a3b8hyyr	63	95	(	(	-LRB-
cord-006860-a3b8hyyr	63	96	n=2	n=2	NNP
cord-006860-a3b8hyyr	63	97	)	)	-RRB-
cord-006860-a3b8hyyr	63	98	.	.	.
cord-006860-a3b8hyyr	64	1	Four	four	CD
cord-006860-a3b8hyyr	64	2	ont	ont	NNS
cord-006860-a3b8hyyr	64	3	of	of	IN
cord-006860-a3b8hyyr	64	4	these	these	DT
cord-006860-a3b8hyyr	64	5	38	38	CD
cord-006860-a3b8hyyr	64	6	patients	patient	NNS
cord-006860-a3b8hyyr	64	7	showed	show	VBD
cord-006860-a3b8hyyr	64	8	a	a	DT
cord-006860-a3b8hyyr	64	9	positive	positive	JJ
cord-006860-a3b8hyyr	64	10	history	history	NN
cord-006860-a3b8hyyr	64	11	of	of	IN
cord-006860-a3b8hyyr	64	12	unexplained	unexplained	JJ
cord-006860-a3b8hyyr	64	13	familial	familial	JJ
cord-006860-a3b8hyyr	64	14	thrombophilia	thrombophilia	NN
cord-006860-a3b8hyyr	64	15	.	.	.
cord-006860-a3b8hyyr	65	1	APCR	APCR	NNP
cord-006860-a3b8hyyr	65	2	was	be	VBD
cord-006860-a3b8hyyr	65	3	measured	measure	VBN
cord-006860-a3b8hyyr	65	4	in	in	IN
cord-006860-a3b8hyyr	65	5	an	an	DT
cord-006860-a3b8hyyr	65	6	activated	activate	VBN
cord-006860-a3b8hyyr	65	7	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	65	8	time	time	NN
cord-006860-a3b8hyyr	65	9	(	(	-LRB-
cord-006860-a3b8hyyr	65	10	aFIT	aFIT	NNP
cord-006860-a3b8hyyr	65	11	)	)	-RRB-
cord-006860-a3b8hyyr	66	1	according	accord	VBG
cord-006860-a3b8hyyr	66	2	to	to	IN
cord-006860-a3b8hyyr	66	3	Dahlbtick	Dahlbtick	NNP
cord-006860-a3b8hyyr	66	4	.	.	.
cord-006860-a3b8hyyr	67	1	The	the	DT
cord-006860-a3b8hyyr	67	2	results	result	NNS
cord-006860-a3b8hyyr	67	3	were	be	VBD
cord-006860-a3b8hyyr	67	4	expressed	express	VBN
cord-006860-a3b8hyyr	67	5	as	as	IN
cord-006860-a3b8hyyr	67	6	APC	APC	NNP
cord-006860-a3b8hyyr	67	7	-	-	HYPH
cord-006860-a3b8hyyr	67	8	ratios	ratio	NNS
cord-006860-a3b8hyyr	67	9	:	:	:
cord-006860-a3b8hyyr	67	10	Clotting	clotting	NN
cord-006860-a3b8hyyr	67	11	time	time	NN
cord-006860-a3b8hyyr	67	12	obtained	obtain	VBD
cord-006860-a3b8hyyr	67	13	using	use	VBG
cord-006860-a3b8hyyr	67	14	the	the	DT
cord-006860-a3b8hyyr	67	15	APC	APC	NNP
cord-006860-a3b8hyyr	67	16	/	/	SYM
cord-006860-a3b8hyyr	67	17	Caci2	Caci2	NNS
cord-006860-a3b8hyyr	67	18	-solution	-solution	NN
cord-006860-a3b8hyyr	67	19	divided	divide	VBN
cord-006860-a3b8hyyr	67	20	by	by	IN
cord-006860-a3b8hyyr	67	21	dotting	dot	VBG
cord-006860-a3b8hyyr	67	22	time	time	NN
cord-006860-a3b8hyyr	67	23	obtained	obtain	VBN
cord-006860-a3b8hyyr	67	24	with	with	IN
cord-006860-a3b8hyyr	67	25	CaC12	cac12	NN
cord-006860-a3b8hyyr	67	26	.	.	.
cord-006860-a3b8hyyr	68	1	Concerning	concern	VBG
cord-006860-a3b8hyyr	68	2	the	the	DT
cord-006860-a3b8hyyr	68	3	special	special	JJ
cord-006860-a3b8hyyr	68	4	properties	property	NNS
cord-006860-a3b8hyyr	68	5	of	of	IN
cord-006860-a3b8hyyr	68	6	the	the	DT
cord-006860-a3b8hyyr	68	7	childhood	childhood	NN
cord-006860-a3b8hyyr	68	8	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	68	9	system	system	NN
cord-006860-a3b8hyyr	68	10	,	,	,
cord-006860-a3b8hyyr	68	11	infants	infant	NNS
cord-006860-a3b8hyyr	68	12	and	and	CC
cord-006860-a3b8hyyr	68	13	children	child	NNS
cord-006860-a3b8hyyr	68	14	with	with	IN
cord-006860-a3b8hyyr	68	15	APCR	APCR	NNP
cord-006860-a3b8hyyr	68	16	<	<	XX
cord-006860-a3b8hyyr	68	17	2	2	CD
cord-006860-a3b8hyyr	68	18	were	be	VBD
cord-006860-a3b8hyyr	68	19	considered	consider	VBN
cord-006860-a3b8hyyr	68	20	to	to	TO
cord-006860-a3b8hyyr	68	21	be	be	VB
cord-006860-a3b8hyyr	68	22	APC	APC	NNP
cord-006860-a3b8hyyr	68	23	-	-	HYPH
cord-006860-a3b8hyyr	68	24	resistent	resistent	NN
cord-006860-a3b8hyyr	68	25	only	only	RB
cord-006860-a3b8hyyr	68	26	when	when	WRB
cord-006860-a3b8hyyr	68	27	the	the	DT
cord-006860-a3b8hyyr	68	28	results	result	NNS
cord-006860-a3b8hyyr	68	29	were	be	VBD
cord-006860-a3b8hyyr	68	30	confirmed	confirm	VBN
cord-006860-a3b8hyyr	68	31	in	in	IN
cord-006860-a3b8hyyr	68	32	a	a	DT
cord-006860-a3b8hyyr	68	33	1	1	CD
cord-006860-a3b8hyyr	68	34	:	:	:
cord-006860-a3b8hyyr	69	1	l	l	NN
cord-006860-a3b8hyyr	69	2	1	1	CD
cord-006860-a3b8hyyr	69	3	dilution	dilution	NN
cord-006860-a3b8hyyr	69	4	with	with	IN
cord-006860-a3b8hyyr	69	5	factor	factor	NN
cord-006860-a3b8hyyr	69	6	V	v	NN
cord-006860-a3b8hyyr	69	7	deficient	deficient	JJ
cord-006860-a3b8hyyr	69	8	plasma	plasma	NN
cord-006860-a3b8hyyr	70	1	(	(	-LRB-
cord-006860-a3b8hyyr	70	2	Instrumentation	Instrumentation	NNP
cord-006860-a3b8hyyr	70	3	Laboratory	Laboratory	NNP
cord-006860-a3b8hyyr	70	4	Munich	Munich	NNP
cord-006860-a3b8hyyr	70	5	,	,	,
cord-006860-a3b8hyyr	70	6	Germany	Germany	NNP
cord-006860-a3b8hyyr	70	7	)	)	-RRB-
cord-006860-a3b8hyyr	70	8	.	.	.
cord-006860-a3b8hyyr	71	1	Plasma	plasma	NN
cord-006860-a3b8hyyr	71	2	of	of	IN
cord-006860-a3b8hyyr	71	3	268	268	CD
cord-006860-a3b8hyyr	71	4	healthy	healthy	JJ
cord-006860-a3b8hyyr	71	5	children	child	NNS
cord-006860-a3b8hyyr	71	6	served	serve	VBD
cord-006860-a3b8hyyr	71	7	as	as	IN
cord-006860-a3b8hyyr	71	8	controls	control	NNS
cord-006860-a3b8hyyr	71	9	.	.	.
cord-006860-a3b8hyyr	72	1	The	the	DT
cord-006860-a3b8hyyr	72	2	Arg	Arg	NNP
cord-006860-a3b8hyyr	72	3	506	506	CD
cord-006860-a3b8hyyr	72	4	Gin	Gin	NNP
cord-006860-a3b8hyyr	72	5	mutation	mutation	NN
cord-006860-a3b8hyyr	72	6	of	of	IN
cord-006860-a3b8hyyr	72	7	the	the	DT
cord-006860-a3b8hyyr	72	8	factor	factor	NN
cord-006860-a3b8hyyr	72	9	V	V	NNP
cord-006860-a3b8hyyr	72	10	gene	gene	NN
cord-006860-a3b8hyyr	72	11	was	be	VBD
cord-006860-a3b8hyyr	72	12	assayed	assay	VBN
cord-006860-a3b8hyyr	72	13	by	by	IN
cord-006860-a3b8hyyr	72	14	amplification	amplification	NN
cord-006860-a3b8hyyr	72	15	of	of	IN
cord-006860-a3b8hyyr	72	16	the	the	DT
cord-006860-a3b8hyyr	72	17	DNA	dna	NN
cord-006860-a3b8hyyr	72	18	samples	sample	NNS
cord-006860-a3b8hyyr	72	19	by	by	IN
cord-006860-a3b8hyyr	72	20	PCR	PCR	NNP
cord-006860-a3b8hyyr	72	21	followed	follow	VBN
cord-006860-a3b8hyyr	72	22	by	by	IN
cord-006860-a3b8hyyr	72	23	digestion	digestion	NN
cord-006860-a3b8hyyr	72	24	of	of	IN
cord-006860-a3b8hyyr	72	25	the	the	DT
cord-006860-a3b8hyyr	72	26	amplified	amplify	VBN
cord-006860-a3b8hyyr	72	27	products	product	NNS
cord-006860-a3b8hyyr	72	28	with	with	IN
cord-006860-a3b8hyyr	72	29	the	the	DT
cord-006860-a3b8hyyr	72	30	restriction	restriction	NN
cord-006860-a3b8hyyr	72	31	enzyme	enzyme	NN
cord-006860-a3b8hyyr	72	32	MUl	MUl	NNP
cord-006860-a3b8hyyr	72	33	I.	I.	NNP
cord-006860-a3b8hyyr	72	34	Results	result	NNS
cord-006860-a3b8hyyr	72	35	were	be	VBD
cord-006860-a3b8hyyr	72	36	confirmed	confirm	VBN
cord-006860-a3b8hyyr	72	37	by	by	IN
cord-006860-a3b8hyyr	72	38	SSCP	SSCP	NNP
cord-006860-a3b8hyyr	72	39	-analysis	-analysis	JJ
cord-006860-a3b8hyyr	72	40	or	or	CC
cord-006860-a3b8hyyr	72	41	by	by	IN
cord-006860-a3b8hyyr	72	42	direct	direct	JJ
cord-006860-a3b8hyyr	72	43	sequencing	sequencing	NN
cord-006860-a3b8hyyr	72	44	of	of	IN
cord-006860-a3b8hyyr	72	45	DNA	dna	NN
cord-006860-a3b8hyyr	72	46	from	from	IN
cord-006860-a3b8hyyr	72	47	patients	patient	NNS
cord-006860-a3b8hyyr	72	48	with	with	IN
cord-006860-a3b8hyyr	72	49	APCR	APCR	NNP
cord-006860-a3b8hyyr	72	50	.	.	.
cord-006860-a3b8hyyr	73	1	Consistent	consistent	JJ
cord-006860-a3b8hyyr	73	2	with	with	IN
cord-006860-a3b8hyyr	73	3	the	the	DT
cord-006860-a3b8hyyr	73	4	aP'IT	aP'IT	NNP
cord-006860-a3b8hyyr	73	5	based	base	VBN
cord-006860-a3b8hyyr	73	6	method	method	NN
cord-006860-a3b8hyyr	73	7	10	10	CD
cord-006860-a3b8hyyr	73	8	out	out	IN
cord-006860-a3b8hyyr	73	9	of	of	IN
cord-006860-a3b8hyyr	73	10	19	19	CD
cord-006860-a3b8hyyr	73	11	children	child	NNS
cord-006860-a3b8hyyr	73	12	with	with	IN
cord-006860-a3b8hyyr	73	13	venous	venous	JJ
cord-006860-a3b8hyyr	73	14	(	(	-LRB-
cord-006860-a3b8hyyr	73	15	V	v	NN
cord-006860-a3b8hyyr	73	16	)	)	-RRB-
cord-006860-a3b8hyyr	73	17	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	73	18	and	and	CC
cord-006860-a3b8hyyr	73	19	eight	eight	CD
cord-006860-a3b8hyyr	73	20	out	out	IN
cord-006860-a3b8hyyr	73	21	of	of	IN
cord-006860-a3b8hyyr	73	22	19	19	CD
cord-006860-a3b8hyyr	73	23	patients	patient	NNS
cord-006860-a3b8hyyr	73	24	with	with	IN
cord-006860-a3b8hyyr	73	25	arterial	arterial	JJ
cord-006860-a3b8hyyr	73	26	(	(	-LRB-
cord-006860-a3b8hyyr	73	27	A	a	NN
cord-006860-a3b8hyyr	73	28	)	)	-RRB-
cord-006860-a3b8hyyr	74	1	vascular	vascular	JJ
cord-006860-a3b8hyyr	74	2	insults	insult	NNS
cord-006860-a3b8hyyr	74	3	showed	show	VBD
cord-006860-a3b8hyyr	74	4	the	the	DT
cord-006860-a3b8hyyr	74	5	common	common	JJ
cord-006860-a3b8hyyr	74	6	factor	factor	NN
cord-006860-a3b8hyyr	74	7	V	v	NN
cord-006860-a3b8hyyr	74	8	mutation	mutation	NN
cord-006860-a3b8hyyr	74	9	.	.	.
cord-006860-a3b8hyyr	75	1	Additional	additional	JJ
cord-006860-a3b8hyyr	75	2	coagulation	coagulation	NN
cord-006860-a3b8hyyr	75	3	defects	defect	NNS
cord-006860-a3b8hyyr	75	4	(	(	-LRB-
cord-006860-a3b8hyyr	75	5	autithrombin	autithrombin	NNP
cord-006860-a3b8hyyr	75	6	,	,	,
cord-006860-a3b8hyyr	75	7	protein	protein	NN
cord-006860-a3b8hyyr	75	8	C	c	NN
cord-006860-a3b8hyyr	75	9	type	type	NN
cord-006860-a3b8hyyr	75	10	I	i	NN
cord-006860-a3b8hyyr	75	11	,	,	,
cord-006860-a3b8hyyr	75	12	enhanced	enhance	VBD
cord-006860-a3b8hyyr	75	13	antiphospbolipid	antiphospbolipid	NNP
cord-006860-a3b8hyyr	75	14	IgG	IgG	NNP
cord-006860-a3b8hyyr	75	15	,	,	,
cord-006860-a3b8hyyr	75	16	enhanced	enhanced	JJ
cord-006860-a3b8hyyr	75	17	lipoprotein	lipoprotein	NN
cord-006860-a3b8hyyr	75	18	(	(	-LRB-
cord-006860-a3b8hyyr	75	19	a	a	NN
cord-006860-a3b8hyyr	75	20	)	)	-RRB-
cord-006860-a3b8hyyr	75	21	)	)	-RRB-
cord-006860-a3b8hyyr	75	22	were	be	VBD
cord-006860-a3b8hyyr	75	23	found	find	VBN
cord-006860-a3b8hyyr	75	24	in	in	IN
cord-006860-a3b8hyyr	75	25	30	30	CD
cord-006860-a3b8hyyr	75	26	%	%	NN
cord-006860-a3b8hyyr	75	27	(	(	-LRB-
cord-006860-a3b8hyyr	75	28	V	v	NN
cord-006860-a3b8hyyr	75	29	)	)	-RRB-
cord-006860-a3b8hyyr	75	30	and	and	CC
cord-006860-a3b8hyyr	75	31	28	28	CD
cord-006860-a3b8hyyr	75	32	%	%	NN
cord-006860-a3b8hyyr	75	33	(	(	-LRB-
cord-006860-a3b8hyyr	75	34	A	a	NN
cord-006860-a3b8hyyr	75	35	)	)	-RRB-
cord-006860-a3b8hyyr	75	36	.	.	.
cord-006860-a3b8hyyr	76	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	76	2	,	,	,
cord-006860-a3b8hyyr	76	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	76	4	diagnosed	diagnose	VBD
cord-006860-a3b8hyyr	76	5	exogenlc	exogenlc	NN
cord-006860-a3b8hyyr	76	6	reasons	reason	NNS
cord-006860-a3b8hyyr	76	7	(	(	-LRB-
cord-006860-a3b8hyyr	76	8	septicemia	septicemia	NN
cord-006860-a3b8hyyr	76	9	,	,	,
cord-006860-a3b8hyyr	76	10	postpastal	postpastal	NNP
cord-006860-a3b8hyyr	76	11	asphyxia	asphyxia	NNP
cord-006860-a3b8hyyr	76	12	,	,	,
cord-006860-a3b8hyyr	76	13	fetopathia	fetopathia	NNP
cord-006860-a3b8hyyr	76	14	diabetica	diabetica	NNP
cord-006860-a3b8hyyr	76	15	,	,	,
cord-006860-a3b8hyyr	76	16	central	central	JJ
cord-006860-a3b8hyyr	76	17	line	line	NN
cord-006860-a3b8hyyr	76	18	and	and	CC
cord-006860-a3b8hyyr	76	19	steroid	steroid	NN
cord-006860-a3b8hyyr	76	20	/	/	SYM
cord-006860-a3b8hyyr	76	21	asparaginase	asparaginase	NNP
cord-006860-a3b8hyyr	76	22	administration	administration	NN
cord-006860-a3b8hyyr	76	23	)	)	-RRB-
cord-006860-a3b8hyyr	76	24	in	in	IN
cord-006860-a3b8hyyr	76	25	six	six	CD
cord-006860-a3b8hyyr	76	26	out	out	IN
cord-006860-a3b8hyyr	76	27	of	of	IN
cord-006860-a3b8hyyr	76	28	10	10	CD
cord-006860-a3b8hyyr	76	29	(	(	-LRB-
cord-006860-a3b8hyyr	76	30	V	v	NN
cord-006860-a3b8hyyr	76	31	)	)	-RRB-
cord-006860-a3b8hyyr	76	32	and	and	CC
cord-006860-a3b8hyyr	76	33	three	three	CD
cord-006860-a3b8hyyr	76	34	out	out	IN
cord-006860-a3b8hyyr	76	35	of	of	IN
cord-006860-a3b8hyyr	76	36	8	8	CD
cord-006860-a3b8hyyr	76	37	(	(	-LRB-
cord-006860-a3b8hyyr	76	38	A	a	NN
cord-006860-a3b8hyyr	76	39	)	)	-RRB-
cord-006860-a3b8hyyr	76	40	children	child	NNS
cord-006860-a3b8hyyr	76	41	with	with	IN
cord-006860-a3b8hyyr	76	42	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	76	43	and	and	CC
cord-006860-a3b8hyyr	76	44	APCR	APCR	NNP
cord-006860-a3b8hyyr	76	45	.	.	.
cord-006860-a3b8hyyr	77	1	All	all	DT
cord-006860-a3b8hyyr	77	2	four	four	CD
cord-006860-a3b8hyyr	77	3	patients	patient	NNS
cord-006860-a3b8hyyr	77	4	with	with	IN
cord-006860-a3b8hyyr	77	5	a	a	DT
cord-006860-a3b8hyyr	77	6	positive	positive	JJ
cord-006860-a3b8hyyr	77	7	family	family	NN
cord-006860-a3b8hyyr	77	8	history	history	NN
cord-006860-a3b8hyyr	77	9	of	of	IN
cord-006860-a3b8hyyr	77	10	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	77	11	(	(	-LRB-
cord-006860-a3b8hyyr	77	12	mothers	mother	NNS
cord-006860-a3b8hyyr	77	13	only	only	RB
cord-006860-a3b8hyyr	77	14	!	!	.
cord-006860-a3b8hyyr	77	15	)	)	-RRB-
cord-006860-a3b8hyyr	77	16	showed	show	VBD
cord-006860-a3b8hyyr	77	17	the	the	DT
cord-006860-a3b8hyyr	77	18	common	common	JJ
cord-006860-a3b8hyyr	77	19	factor	factor	NN
cord-006860-a3b8hyyr	77	20	V	v	NN
cord-006860-a3b8hyyr	77	21	mutation	mutation	NN
cord-006860-a3b8hyyr	77	22	Arg	arg	NN
cord-006860-a3b8hyyr	77	23	506	506	CD
cord-006860-a3b8hyyr	77	24	Gin	Gin	NNP
cord-006860-a3b8hyyr	77	25	.	.	.
cord-006860-a3b8hyyr	78	1	In	in	IN
cord-006860-a3b8hyyr	78	2	the	the	DT
cord-006860-a3b8hyyr	78	3	control	control	NN
cord-006860-a3b8hyyr	78	4	group	group	NN
cord-006860-a3b8hyyr	78	5	the	the	DT
cord-006860-a3b8hyyr	78	6	prevalence	prevalence	NN
cord-006860-a3b8hyyr	78	7	of	of	IN
cord-006860-a3b8hyyr	78	8	APCR	APCR	NNP
cord-006860-a3b8hyyr	78	9	was	be	VBD
cord-006860-a3b8hyyr	78	10	5.1	5.1	CD
cord-006860-a3b8hyyr	78	11	%	%	NN
cord-006860-a3b8hyyr	78	12	.	.	.
cord-006860-a3b8hyyr	79	1	The	the	DT
cord-006860-a3b8hyyr	79	2	high	high	JJ
cord-006860-a3b8hyyr	79	3	incidence	incidence	NN
cord-006860-a3b8hyyr	79	4	of	of	IN
cord-006860-a3b8hyyr	79	5	additional	additional	JJ
cord-006860-a3b8hyyr	79	6	exengenic	exengenic	JJ
cord-006860-a3b8hyyr	79	7	factors	factor	NNS
cord-006860-a3b8hyyr	79	8	in	in	IN
cord-006860-a3b8hyyr	79	9	children	child	NNS
cord-006860-a3b8hyyr	79	10	with	with	IN
cord-006860-a3b8hyyr	79	11	APCR	APCR	NNP
cord-006860-a3b8hyyr	79	12	confirm	confirm	VBP
cord-006860-a3b8hyyr	79	13	literature	literature	NN
cord-006860-a3b8hyyr	79	14	data	datum	NNS
cord-006860-a3b8hyyr	79	15	of	of	IN
cord-006860-a3b8hyyr	79	16	previously	previously	RB
cord-006860-a3b8hyyr	79	17	described	describe	VBN
cord-006860-a3b8hyyr	79	18	inherited	inherit	VBN
cord-006860-a3b8hyyr	79	19	coagulation	coagulation	NN
cord-006860-a3b8hyyr	79	20	disorders	disorder	NNS
cord-006860-a3b8hyyr	79	21	during	during	IN
cord-006860-a3b8hyyr	79	22	infancy	infancy	NN
cord-006860-a3b8hyyr	79	23	and	and	CC
cord-006860-a3b8hyyr	79	24	childhood	childhood	NN
cord-006860-a3b8hyyr	79	25	:	:	:
cord-006860-a3b8hyyr	80	1	An	an	DT
cord-006860-a3b8hyyr	80	2	acquired	acquire	VBN
cord-006860-a3b8hyyr	80	3	risk	risk	NN
cord-006860-a3b8hyyr	80	4	of	of	IN
cord-006860-a3b8hyyr	80	5	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	80	6	disorders	disorder	NNS
cord-006860-a3b8hyyr	80	7	masks	mask	VBZ
cord-006860-a3b8hyyr	80	8	the	the	DT
cord-006860-a3b8hyyr	80	9	coagulation	coagulation	NN
cord-006860-a3b8hyyr	80	10	deficiency	deficiency	NN
cord-006860-a3b8hyyr	80	11	in	in	IN
cord-006860-a3b8hyyr	80	12	the	the	DT
cord-006860-a3b8hyyr	80	13	majority	majority	NN
cord-006860-a3b8hyyr	80	14	of	of	IN
cord-006860-a3b8hyyr	80	15	patients	patient	NNS
cord-006860-a3b8hyyr	80	16	with	with	IN
cord-006860-a3b8hyyr	80	17	an	an	DT
cord-006860-a3b8hyyr	80	18	inherited	inherit	VBN
cord-006860-a3b8hyyr	80	19	prethrombotic	prethrombotic	JJ
cord-006860-a3b8hyyr	80	20	state	state	NN
cord-006860-a3b8hyyr	80	21	.	.	.
cord-006860-a3b8hyyr	81	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	81	2	,	,	,
cord-006860-a3b8hyyr	81	3	the	the	DT
cord-006860-a3b8hyyr	81	4	incidence	incidence	NN
cord-006860-a3b8hyyr	81	5	of	of	IN
cord-006860-a3b8hyyr	81	6	42	42	CD
cord-006860-a3b8hyyr	81	7	%	%	NN
cord-006860-a3b8hyyr	81	8	APC	APC	NNP
cord-006860-a3b8hyyr	81	9	resistant	resistant	JJ
cord-006860-a3b8hyyr	81	10	children	child	NNS
cord-006860-a3b8hyyr	81	11	with	with	IN
cord-006860-a3b8hyyr	81	12	arterial	arterial	JJ
cord-006860-a3b8hyyr	81	13	insults	insult	NNS
cord-006860-a3b8hyyr	81	14	in	in	IN
cord-006860-a3b8hyyr	81	15	this	this	DT
cord-006860-a3b8hyyr	81	16	study	study	NN
cord-006860-a3b8hyyr	81	17	challenge	challenge	VBP
cord-006860-a3b8hyyr	81	18	the	the	DT
cord-006860-a3b8hyyr	81	19	view	view	NN
cord-006860-a3b8hyyr	81	20	that	that	IN
cord-006860-a3b8hyyr	81	21	APCR	APCR	NNP
cord-006860-a3b8hyyr	81	22	is	be	VBZ
cord-006860-a3b8hyyr	81	23	associated	associate	VBN
cord-006860-a3b8hyyr	81	24	with	with	IN
cord-006860-a3b8hyyr	81	25	venous	venous	JJ
cord-006860-a3b8hyyr	81	26	but	but	CC
cord-006860-a3b8hyyr	81	27	not	not	RB
cord-006860-a3b8hyyr	81	28	with	with	IN
cord-006860-a3b8hyyr	81	29	arterial	arterial	JJ
cord-006860-a3b8hyyr	81	30	thrombo	thrombo	NNP
cord-006860-a3b8hyyr	81	31	-	-	HYPH
cord-006860-a3b8hyyr	81	32	st8	st8	NNP
cord-006860-a3b8hyyr	81	33	.	.	.
cord-006860-a3b8hyyr	82	1	12	12	CD
cord-006860-a3b8hyyr	83	1	ACTIVATED	ACTIVATED	NNP
cord-006860-a3b8hyyr	83	2	PROTEIN	protein	NN
cord-006860-a3b8hyyr	83	3	C	C	NNP
cord-006860-a3b8hyyr	83	4	RESISTANCE	resistance	NN
cord-006860-a3b8hyyr	83	5	AND	and	CC
cord-006860-a3b8hyyr	83	6	PLASMINOGEN	plasminogen	NN
cord-006860-a3b8hyyr	83	7	DEFICIENCY	deficiency	NN
cord-006860-a3b8hyyr	83	8	IN	in	IN
cord-006860-a3b8hyyr	83	9	A	a	DT
cord-006860-a3b8hyyr	83	10	FAMILY	family	NN
cord-006860-a3b8hyyr	83	11	WITH	with	IN
cord-006860-a3b8hyyr	83	12	THROMBOPHILIA	THROMBOPHILIA	NNP
cord-006860-a3b8hyyr	83	13	M	M	NNP
cord-006860-a3b8hyyr	83	14	,	,	,
cord-006860-a3b8hyyr	83	15	Zttger	Zttger	NNP
cord-006860-a3b8hyyr	83	16	1	1	CD
cord-006860-a3b8hyyr	83	17	,	,	,
cord-006860-a3b8hyyr	83	18	F.	F.	NNP
cord-006860-a3b8hyyr	83	19	Demarmels	Demarmels	NNP
cord-006860-a3b8hyyr	83	20	Biasiutti	Biasiutti	NNP
cord-006860-a3b8hyyr	83	21	1	1	CD
cord-006860-a3b8hyyr	83	22	,	,	,
cord-006860-a3b8hyyr	83	23	Ch	Ch	NNP
cord-006860-a3b8hyyr	83	24	.	.	.
cord-006860-a3b8hyyr	84	1	Mannhalter	Mannhalter	NNP
cord-006860-a3b8hyyr	84	2	2	2	CD
cord-006860-a3b8hyyr	84	3	,	,	,
cord-006860-a3b8hyyr	84	4	M.	M.	NNP
cord-006860-a3b8hyyr	84	5	Furlan	Furlan	NNP
cord-006860-a3b8hyyr	84	6	1	1	CD
cord-006860-a3b8hyyr	84	7	,	,	,
cord-006860-a3b8hyyr	84	8	B.~e	B.~e	NNP
cord-006860-a3b8hyyr	85	1	1	1	CD
cord-006860-a3b8hyyr	85	2	1Httmatologisches	1httmatologisches	CD
cord-006860-a3b8hyyr	85	3	Zentrallabor	Zentrallabor	NNP
cord-006860-a3b8hyyr	85	4	der	der	NN
cord-006860-a3b8hyyr	85	5	Universit	Universit	NNP
cord-006860-a3b8hyyr	86	1	~t	~t	NNP
cord-006860-a3b8hyyr	86	2	,	,	,
cord-006860-a3b8hyyr	86	3	Inselspital	Inselspital	NNP
cord-006860-a3b8hyyr	86	4	,	,	,
cord-006860-a3b8hyyr	87	1	CH-3010	CH-3010	NNP
cord-006860-a3b8hyyr	87	2	Bern	Bern	NNP
cord-006860-a3b8hyyr	87	3	2Klinisches	2Klinisches	NNP
cord-006860-a3b8hyyr	87	4	Institut	Institut	NNP
cord-006860-a3b8hyyr	87	5	fur	fur	NN
cord-006860-a3b8hyyr	87	6	medizinische	medizinische	NN
cord-006860-a3b8hyyr	88	1	und	und	NNP
cord-006860-a3b8hyyr	89	1	ehemische	ehemische	NNP
cord-006860-a3b8hyyr	89	2	Labordiagnostik	Labordiagnostik	NNP
cord-006860-a3b8hyyr	89	3	,	,	,
cord-006860-a3b8hyyr	89	4	Universit	Universit	NNP
cord-006860-a3b8hyyr	89	5	~	~	NFP
cord-006860-a3b8hyyr	89	6	t	t	NNP
cord-006860-a3b8hyyr	89	7	Wien	Wien	NNP
cord-006860-a3b8hyyr	89	8	,	,	,
cord-006860-a3b8hyyr	89	9	A-1090	A-1090	NNP
cord-006860-a3b8hyyr	89	10	Wien	Wien	NNP
cord-006860-a3b8hyyr	89	11	Several	several	JJ
cord-006860-a3b8hyyr	89	12	hereditary	hereditary	JJ
cord-006860-a3b8hyyr	89	13	defects	defect	NNS
cord-006860-a3b8hyyr	89	14	of	of	IN
cord-006860-a3b8hyyr	89	15	the	the	DT
cord-006860-a3b8hyyr	89	16	proteins	protein	NNS
cord-006860-a3b8hyyr	89	17	regulating	regulate	VBG
cord-006860-a3b8hyyr	89	18	blood	blood	NN
cord-006860-a3b8hyyr	89	19	coagulation	coagulation	NN
cord-006860-a3b8hyyr	89	20	have	have	VBP
cord-006860-a3b8hyyr	89	21	been	be	VBN
cord-006860-a3b8hyyr	89	22	associated	associate	VBN
cord-006860-a3b8hyyr	89	23	with	with	IN
cord-006860-a3b8hyyr	89	24	familial	familial	JJ
cord-006860-a3b8hyyr	89	25	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	89	26	.	.	.
cord-006860-a3b8hyyr	90	1	Since	since	IN
cord-006860-a3b8hyyr	90	2	the	the	DT
cord-006860-a3b8hyyr	90	3	recent	recent	JJ
cord-006860-a3b8hyyr	90	4	discovery	discovery	NN
cord-006860-a3b8hyyr	90	5	of	of	IN
cord-006860-a3b8hyyr	90	6	activated	activate	VBN
cord-006860-a3b8hyyr	90	7	protein	protein	NN
cord-006860-a3b8hyyr	90	8	C	C	NNP
cord-006860-a3b8hyyr	90	9	(	(	-LRB-
cord-006860-a3b8hyyr	90	10	APC	APC	NNP
cord-006860-a3b8hyyr	90	11	)	)	-RRB-
cord-006860-a3b8hyyr	90	12	resistance	resistance	NN
cord-006860-a3b8hyyr	90	13	due	due	IN
cord-006860-a3b8hyyr	90	14	to	to	IN
cord-006860-a3b8hyyr	90	15	the	the	DT
cord-006860-a3b8hyyr	90	16	factor	factor	NN
cord-006860-a3b8hyyr	90	17	V	v	NN
cord-006860-a3b8hyyr	90	18	Rf06Q	rf06q	NN
cord-006860-a3b8hyyr	90	19	mutation	mutation	NN
cord-006860-a3b8hyyr	90	20	as	as	IN
cord-006860-a3b8hyyr	90	21	a	a	DT
cord-006860-a3b8hyyr	90	22	highly	highly	RB
cord-006860-a3b8hyyr	90	23	prevalent	prevalent	JJ
cord-006860-a3b8hyyr	90	24	hereditary	hereditary	JJ
cord-006860-a3b8hyyr	90	25	risk	risk	NN
cord-006860-a3b8hyyr	90	26	factor	factor	NN
cord-006860-a3b8hyyr	90	27	for	for	IN
cord-006860-a3b8hyyr	90	28	venous	venous	JJ
cord-006860-a3b8hyyr	90	29	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	90	30	(	(	-LRB-
cord-006860-a3b8hyyr	90	31	TEl	TEl	NNS
cord-006860-a3b8hyyr	90	32	,	,	,
cord-006860-a3b8hyyr	90	33	evidence	evidence	NN
cord-006860-a3b8hyyr	90	34	is	be	VBZ
cord-006860-a3b8hyyr	90	35	accumulating	accumulate	VBG
cord-006860-a3b8hyyr	90	36	that	that	IN
cord-006860-a3b8hyyr	90	37	familial	familial	JJ
cord-006860-a3b8hyyr	90	38	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	90	39	may	may	MD
cord-006860-a3b8hyyr	90	40	be	be	VB
cord-006860-a3b8hyyr	90	41	due	due	JJ
cord-006860-a3b8hyyr	90	42	to	to	IN
cord-006860-a3b8hyyr	90	43	a	a	DT
cord-006860-a3b8hyyr	90	44	combination	combination	NN
cord-006860-a3b8hyyr	90	45	of	of	IN
cord-006860-a3b8hyyr	90	46	genetic	genetic	JJ
cord-006860-a3b8hyyr	90	47	defects	defect	NNS
cord-006860-a3b8hyyr	90	48	.	.	.
cord-006860-a3b8hyyr	91	1	Thus	thus	RB
cord-006860-a3b8hyyr	91	2	,	,	,
cord-006860-a3b8hyyr	91	3	protein	protein	NN
cord-006860-a3b8hyyr	91	4	C	c	NN
cord-006860-a3b8hyyr	91	5	-	-	,
cord-006860-a3b8hyyr	91	6	or	or	CC
cord-006860-a3b8hyyr	91	7	protein	protein	NN
cord-006860-a3b8hyyr	91	8	S	s	NN
cord-006860-a3b8hyyr	91	9	-	-	HYPH
cord-006860-a3b8hyyr	91	10	deficient	deficient	JJ
cord-006860-a3b8hyyr	91	11	patients	patient	NNS
cord-006860-a3b8hyyr	91	12	having	have	VBG
cord-006860-a3b8hyyr	91	13	suffered	suffer	VBN
cord-006860-a3b8hyyr	91	14	from	from	IN
cord-006860-a3b8hyyr	91	15	TE	TE	NNP
cord-006860-a3b8hyyr	91	16	seem	seem	VB
cord-006860-a3b8hyyr	91	17	to	to	TO
cord-006860-a3b8hyyr	91	18	be	be	VB
cord-006860-a3b8hyyr	91	19	more	more	RBR
cord-006860-a3b8hyyr	91	20	likely	likely	JJ
cord-006860-a3b8hyyr	91	21	to	to	TO
cord-006860-a3b8hyyr	91	22	carry	carry	VB
cord-006860-a3b8hyyr	91	23	the	the	DT
cord-006860-a3b8hyyr	91	24	factor	factor	NN
cord-006860-a3b8hyyr	91	25	V	v	NN
cord-006860-a3b8hyyr	91	26	R506Q	r506q	NN
cord-006860-a3b8hyyr	91	27	mutation	mutation	NN
cord-006860-a3b8hyyr	91	28	than	than	IN
cord-006860-a3b8hyyr	91	29	expected	expect	VBN
cord-006860-a3b8hyyr	91	30	from	from	IN
cord-006860-a3b8hyyr	91	31	its	-PRON-	PRP$
cord-006860-a3b8hyyr	91	32	allelic	allelic	JJ
cord-006860-a3b8hyyr	91	33	frequency	frequency	NN
cord-006860-a3b8hyyr	91	34	in	in	IN
cord-006860-a3b8hyyr	91	35	the	the	DT
cord-006860-a3b8hyyr	91	36	population	population	NN
cord-006860-a3b8hyyr	91	37	.	.	.
cord-006860-a3b8hyyr	92	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	92	2	report	report	VBP
cord-006860-a3b8hyyr	92	3	a	a	DT
cord-006860-a3b8hyyr	92	4	family	family	NN
cord-006860-a3b8hyyr	92	5	(	(	-LRB-
cord-006860-a3b8hyyr	92	6	see	see	VB
cord-006860-a3b8hyyr	92	7	figure	figure	NN
cord-006860-a3b8hyyr	92	8	)	)	-RRB-
cord-006860-a3b8hyyr	92	9	in	in	IN
cord-006860-a3b8hyyr	92	10	which	which	WDT
cord-006860-a3b8hyyr	92	11	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	92	12	deficiency	deficiency	NN
cord-006860-a3b8hyyr	92	13	(	(	-LRB-
cord-006860-a3b8hyyr	92	14	0.60	0.60	CD
cord-006860-a3b8hyyr	92	15	U	U	NNP
cord-006860-a3b8hyyr	92	16	/	/	SYM
cord-006860-a3b8hyyr	92	17	ml	ml	NN
cord-006860-a3b8hyyr	92	18	)	)	-RRB-
cord-006860-a3b8hyyr	92	19	had	have	VBD
cord-006860-a3b8hyyr	92	20	been	be	VBN
cord-006860-a3b8hyyr	92	21	found	find	VBN
cord-006860-a3b8hyyr	92	22	in	in	IN
cord-006860-a3b8hyyr	92	23	the	the	DT
cord-006860-a3b8hyyr	92	24	propositus	propositus	NN
cord-006860-a3b8hyyr	92	25	having	have	VBG
cord-006860-a3b8hyyr	92	26	had	have	VBN
cord-006860-a3b8hyyr	92	27	twice	twice	RB
cord-006860-a3b8hyyr	92	28	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	92	29	deep	deep	JJ
cord-006860-a3b8hyyr	92	30	vein	vein	NN
cord-006860-a3b8hyyr	92	31	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	92	32	(	(	-LRB-
cord-006860-a3b8hyyr	92	33	DVT	DVT	NNP
cord-006860-a3b8hyyr	92	34	)	)	-RRB-
cord-006860-a3b8hyyr	92	35	at	at	IN
cord-006860-a3b8hyyr	92	36	ages	age	NNS
cord-006860-a3b8hyyr	92	37	of	of	IN
cord-006860-a3b8hyyr	92	38	29	29	CD
cord-006860-a3b8hyyr	92	39	and	and	CC
cord-006860-a3b8hyyr	92	40	31	31	CD
cord-006860-a3b8hyyr	92	41	yrs	yr	NNS
cord-006860-a3b8hyyr	92	42	,	,	,
cord-006860-a3b8hyyr	92	43	respectively	respectively	RB
cord-006860-a3b8hyyr	92	44	,	,	,
cord-006860-a3b8hyyr	92	45	as	as	RB
cord-006860-a3b8hyyr	92	46	well	well	RB
cord-006860-a3b8hyyr	92	47	as	as	IN
cord-006860-a3b8hyyr	92	48	in	in	IN
cord-006860-a3b8hyyr	92	49	5	5	CD
cord-006860-a3b8hyyr	92	50	family	family	NN
cord-006860-a3b8hyyr	92	51	members	member	NNS
cord-006860-a3b8hyyr	92	52	(	(	-LRB-
cord-006860-a3b8hyyr	92	53	0.53	0.53	CD
cord-006860-a3b8hyyr	92	54	-	-	SYM
cord-006860-a3b8hyyr	92	55	0.69	0.69	CD
cord-006860-a3b8hyyr	92	56	U	U	NNP
cord-006860-a3b8hyyr	92	57	/	/	SYM
cord-006860-a3b8hyyr	92	58	ml	ml	NN
cord-006860-a3b8hyyr	92	59	)	)	-RRB-
cord-006860-a3b8hyyr	92	60	.	.	.
cord-006860-a3b8hyyr	93	1	Out	out	IN
cord-006860-a3b8hyyr	93	2	of	of	IN
cord-006860-a3b8hyyr	93	3	these	these	DT
cord-006860-a3b8hyyr	93	4	5	5	CD
cord-006860-a3b8hyyr	93	5	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	93	6	deficient	deficient	JJ
cord-006860-a3b8hyyr	93	7	individuals	individual	NNS
cord-006860-a3b8hyyr	93	8	,	,	,
cord-006860-a3b8hyyr	93	9	only	only	RB
cord-006860-a3b8hyyr	93	10	the	the	DT
cord-006860-a3b8hyyr	93	11	propositus	propositus	NN
cord-006860-a3b8hyyr	93	12	'	'	POS
cord-006860-a3b8hyyr	93	13	daughter	daughter	NN
cord-006860-a3b8hyyr	93	14	had	have	VBD
cord-006860-a3b8hyyr	93	15	suffered	suffer	VBN
cord-006860-a3b8hyyr	93	16	from	from	IN
cord-006860-a3b8hyyr	93	17	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	93	18	DVT	DVT	NNP
cord-006860-a3b8hyyr	93	19	at	at	IN
cord-006860-a3b8hyyr	93	20	age	age	NN
cord-006860-a3b8hyyr	93	21	<	<	XX
cord-006860-a3b8hyyr	93	22	20yrs	20yrs	NNP
cord-006860-a3b8hyyr	93	23	.	.	.
cord-006860-a3b8hyyr	94	1	Reinvestigation	reinvestigation	NN
cord-006860-a3b8hyyr	94	2	of	of	IN
cord-006860-a3b8hyyr	94	3	this	this	DT
cord-006860-a3b8hyyr	94	4	family	family	NN
cord-006860-a3b8hyyr	94	5	in	in	IN
cord-006860-a3b8hyyr	94	6	1995	1995	CD
cord-006860-a3b8hyyr	94	7	showed	show	VBD
cord-006860-a3b8hyyr	94	8	factor	factor	NN
cord-006860-a3b8hyyr	94	9	V	v	NN
cord-006860-a3b8hyyr	94	10	R506Q	r506q	NN
cord-006860-a3b8hyyr	94	11	mutation	mutation	NN
cord-006860-a3b8hyyr	94	12	in	in	IN
cord-006860-a3b8hyyr	94	13	the	the	DT
cord-006860-a3b8hyyr	94	14	propositus	propositus	NN
cord-006860-a3b8hyyr	94	15	,	,	,
cord-006860-a3b8hyyr	94	16	his	-PRON-	PRP$
cord-006860-a3b8hyyr	94	17	daughter	daughter	NN
cord-006860-a3b8hyyr	94	18	,	,	,
cord-006860-a3b8hyyr	94	19	an	an	DT
cord-006860-a3b8hyyr	94	20	asymptomatic	asymptomatic	JJ
cord-006860-a3b8hyyr	94	21	sister	sister	NN
cord-006860-a3b8hyyr	94	22	and	and	CC
cord-006860-a3b8hyyr	94	23	a	a	DT
cord-006860-a3b8hyyr	94	24	brother	brother	NN
cord-006860-a3b8hyyr	94	25	with	with	IN
cord-006860-a3b8hyyr	94	26	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	94	27	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	94	28	embolism	embolism	NN
cord-006860-a3b8hyyr	94	29	(	(	-LRB-
cord-006860-a3b8hyyr	94	30	PE	PE	NNP
cord-006860-a3b8hyyr	94	31	)	)	-RRB-
cord-006860-a3b8hyyr	94	32	.	.	.
cord-006860-a3b8hyyr	95	1	His	-PRON-	PRP$
cord-006860-a3b8hyyr	95	2	father	father	NN
cord-006860-a3b8hyyr	95	3	had	have	VBD
cord-006860-a3b8hyyr	95	4	had	have	VBN
cord-006860-a3b8hyyr	95	5	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	95	6	PE	pe	NN
cord-006860-a3b8hyyr	95	7	;	;	:
cord-006860-a3b8hyyr	95	8	he	-PRON-	PRP
cord-006860-a3b8hyyr	95	9	is	be	VBZ
cord-006860-a3b8hyyr	95	10	deceased	deceased	JJ
cord-006860-a3b8hyyr	95	11	and	and	CC
cord-006860-a3b8hyyr	95	12	could	could	MD
cord-006860-a3b8hyyr	95	13	not	not	RB
cord-006860-a3b8hyyr	95	14	be	be	VB
cord-006860-a3b8hyyr	95	15	examined	examine	VBN
cord-006860-a3b8hyyr	95	16	.	.	.
cord-006860-a3b8hyyr	96	1	~	~	NFP
cord-006860-a3b8hyyr	96	2	,	,	,
cord-006860-a3b8hyyr	96	3	[	[	-LRB-
cord-006860-a3b8hyyr	96	4	]	]	-RRB-
cord-006860-a3b8hyyr	96	5	Plasminogen	Plasminogen	NNP
cord-006860-a3b8hyyr	96	6	deficiency	deficiency	NN
cord-006860-a3b8hyyr	96	7	~	~	NFP
cord-006860-a3b8hyyr	96	8	,	,	,
cord-006860-a3b8hyyr	96	9	rll	rll	NNP
cord-006860-a3b8hyyr	96	10	Factor	Factor	NNP
cord-006860-a3b8hyyr	96	11	V	V	NNP
cord-006860-a3b8hyyr	96	12	Rf06Q	rf06q	NN
cord-006860-a3b8hyyr	96	13	mutation	mutation	NN
cord-006860-a3b8hyyr	96	14	/~	/~	.
cord-006860-a3b8hyyr	97	1	Propositus	Propositus	NNP
cord-006860-a3b8hyyr	97	2	~¢	~¢	NFP
cord-006860-a3b8hyyr	97	3	bistory	bistory	NN
cord-006860-a3b8hyyr	97	4	of	of	IN
cord-006860-a3b8hyyr	97	5	DVT	DVT	NNP
cord-006860-a3b8hyyr	97	6	and/or	and/or	CC
cord-006860-a3b8hyyr	98	1	PE	PE	NNP
cord-006860-a3b8hyyr	98	2	e	e	NNP
cord-006860-a3b8hyyr	98	3	superficial	superficial	JJ
cord-006860-a3b8hyyr	98	4	phlebitis	phlebitis	NN
cord-006860-a3b8hyyr	98	5	J2~,,~	J2~,,~	NNP
cord-006860-a3b8hyyr	98	6	not	not	RB
cord-006860-a3b8hyyr	98	7	investigated	investigate	VBN
cord-006860-a3b8hyyr	98	8	"	"	``
cord-006860-a3b8hyyr	98	9	1	1	CD
cord-006860-a3b8hyyr	98	10	"	"	''
cord-006860-a3b8hyyr	98	11	deceased	decease	VBN
cord-006860-a3b8hyyr	99	1	Even	even	RB
cord-006860-a3b8hyyr	99	2	though	though	IN
cord-006860-a3b8hyyr	99	3	this	this	DT
cord-006860-a3b8hyyr	99	4	family	family	NN
cord-006860-a3b8hyyr	99	5	is	be	VBZ
cord-006860-a3b8hyyr	99	6	small	small	JJ
cord-006860-a3b8hyyr	99	7	for	for	IN
cord-006860-a3b8hyyr	99	8	establishing	establish	VBG
cord-006860-a3b8hyyr	99	9	unequivocal	unequivocal	JJ
cord-006860-a3b8hyyr	99	10	association	association	NN
cord-006860-a3b8hyyr	99	11	of	of	IN
cord-006860-a3b8hyyr	99	12	TE	TE	NNP
cord-006860-a3b8hyyr	99	13	with	with	IN
cord-006860-a3b8hyyr	99	14	known	know	VBN
cord-006860-a3b8hyyr	99	15	defects	defect	NNS
cord-006860-a3b8hyyr	99	16	,	,	,
cord-006860-a3b8hyyr	99	17	the	the	DT
cord-006860-a3b8hyyr	99	18	two	two	CD
cord-006860-a3b8hyyr	99	19	most	most	RBS
cord-006860-a3b8hyyr	99	20	severely	severely	RB
cord-006860-a3b8hyyr	99	21	affected	affect	VBN
cord-006860-a3b8hyyr	99	22	individuals	individual	NNS
cord-006860-a3b8hyyr	99	23	with	with	IN
cord-006860-a3b8hyyr	99	24	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	99	25	TE	TE	NNP
cord-006860-a3b8hyyr	99	26	at	at	IN
cord-006860-a3b8hyyr	99	27	ages	age	NNS
cord-006860-a3b8hyyr	99	28	<	<	NNP
cord-006860-a3b8hyyr	99	29	30yrs	30yrs	NNP
cord-006860-a3b8hyyr	99	30	had	have	VBD
cord-006860-a3b8hyyr	99	31	combined	combine	VBN
cord-006860-a3b8hyyr	99	32	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	99	33	deficiency	deficiency	NN
cord-006860-a3b8hyyr	99	34	and	and	CC
cord-006860-a3b8hyyr	99	35	APC	APC	NNP
cord-006860-a3b8hyyr	99	36	resistance	resistance	NN
cord-006860-a3b8hyyr	99	37	whereas	whereas	IN
cord-006860-a3b8hyyr	99	38	those	those	DT
cord-006860-a3b8hyyr	99	39	with	with	IN
cord-006860-a3b8hyyr	99	40	isolated	isolated	JJ
cord-006860-a3b8hyyr	99	41	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	99	42	deficiency	deficiency	NN
cord-006860-a3b8hyyr	99	43	were	be	VBD
cord-006860-a3b8hyyr	99	44	asymptomatic	asymptomatic	JJ
cord-006860-a3b8hyyr	99	45	.	.	.
cord-006860-a3b8hyyr	100	1	These	these	DT
cord-006860-a3b8hyyr	100	2	data	datum	NNS
cord-006860-a3b8hyyr	100	3	support	support	VBP
cord-006860-a3b8hyyr	100	4	the	the	DT
cord-006860-a3b8hyyr	100	5	concept	concept	NN
cord-006860-a3b8hyyr	100	6	of	of	IN
cord-006860-a3b8hyyr	100	7	multigenie	multigenie	JJ
cord-006860-a3b8hyyr	100	8	interactions	interaction	NNS
cord-006860-a3b8hyyr	100	9	leading	lead	VBG
cord-006860-a3b8hyyr	100	10	to	to	IN
cord-006860-a3b8hyyr	100	11	familial	familial	JJ
cord-006860-a3b8hyyr	100	12	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	100	13	.	.	.
cord-006860-a3b8hyyr	101	1	Resistance	resistance	NN
cord-006860-a3b8hyyr	101	2	to	to	IN
cord-006860-a3b8hyyr	101	3	activated	activate	VBN
cord-006860-a3b8hyyr	101	4	protein	protein	NN
cord-006860-a3b8hyyr	101	5	C	C	NNP
cord-006860-a3b8hyyr	101	6	(	(	-LRB-
cord-006860-a3b8hyyr	101	7	APC	APC	NNP
cord-006860-a3b8hyyr	101	8	resistance	resistance	NN
cord-006860-a3b8hyyr	101	9	)	)	-RRB-
cord-006860-a3b8hyyr	101	10	is	be	VBZ
cord-006860-a3b8hyyr	101	11	the	the	DT
cord-006860-a3b8hyyr	101	12	most	most	RBS
cord-006860-a3b8hyyr	101	13	common	common	JJ
cord-006860-a3b8hyyr	101	14	dsk	dsk	NNP
cord-006860-a3b8hyyr	101	15	factor	factor	NN
cord-006860-a3b8hyyr	101	16	for	for	IN
cord-006860-a3b8hyyr	101	17	venous	venous	JJ
cord-006860-a3b8hyyr	101	18	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	101	19	(	(	-LRB-
cord-006860-a3b8hyyr	101	20	VT	VT	NNP
cord-006860-a3b8hyyr	101	21	)	)	-RRB-
cord-006860-a3b8hyyr	101	22	.	.	.
cord-006860-a3b8hyyr	102	1	In	in	IN
cord-006860-a3b8hyyr	102	2	most	most	JJS
cord-006860-a3b8hyyr	102	3	cases	case	NNS
cord-006860-a3b8hyyr	102	4	APC	APC	NNP
cord-006860-a3b8hyyr	102	5	resistance	resistance	NN
cord-006860-a3b8hyyr	102	6	is	be	VBZ
cord-006860-a3b8hyyr	102	7	caused	cause	VBN
cord-006860-a3b8hyyr	102	8	by	by	IN
cord-006860-a3b8hyyr	102	9	a	a	DT
cord-006860-a3b8hyyr	102	10	single	single	JJ
cord-006860-a3b8hyyr	102	11	point	point	NN
cord-006860-a3b8hyyr	102	12	mutation	mutation	NN
cord-006860-a3b8hyyr	102	13	at	at	IN
cord-006860-a3b8hyyr	102	14	position	position	NN
cord-006860-a3b8hyyr	102	15	Arg	Arg	NNP
cord-006860-a3b8hyyr	102	16	506	506	CD
cord-006860-a3b8hyyr	102	17	in	in	IN
cord-006860-a3b8hyyr	102	18	the	the	DT
cord-006860-a3b8hyyr	102	19	factor	factor	NN
cord-006860-a3b8hyyr	102	20	V	v	NN
cord-006860-a3b8hyyr	102	21	gene	gene	NN
cord-006860-a3b8hyyr	102	22	(	(	-LRB-
cord-006860-a3b8hyyr	102	23	factor	factor	NN
cord-006860-a3b8hyyr	102	24	V	V	NNP
cord-006860-a3b8hyyr	102	25	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	102	26	)	)	-RRB-
cord-006860-a3b8hyyr	102	27	.	.	.
cord-006860-a3b8hyyr	103	1	While	while	IN
cord-006860-a3b8hyyr	103	2	ample	ample	JJ
cord-006860-a3b8hyyr	103	3	data	datum	NNS
cord-006860-a3b8hyyr	103	4	in	in	IN
cord-006860-a3b8hyyr	103	5	hetarozygous	hetarozygous	NNP
cord-006860-a3b8hyyr	103	6	patients	patient	NNS
cord-006860-a3b8hyyr	103	7	have	have	VBP
cord-006860-a3b8hyyr	103	8	been	be	VBN
cord-006860-a3b8hyyr	103	9	published	publish	VBN
cord-006860-a3b8hyyr	103	10	,	,	,
cord-006860-a3b8hyyr	103	11	reports	report	NNS
cord-006860-a3b8hyyr	103	12	in	in	IN
cord-006860-a3b8hyyr	103	13	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	103	14	patients	patient	NNS
cord-006860-a3b8hyyr	103	15	are	be	VBP
cord-006860-a3b8hyyr	103	16	limited	limited	JJ
cord-006860-a3b8hyyr	103	17	.	.	.
cord-006860-a3b8hyyr	104	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	104	2	studied	study	VBD
cord-006860-a3b8hyyr	104	3	29	29	CD
cord-006860-a3b8hyyr	104	4	patients	patient	NNS
cord-006860-a3b8hyyr	104	5	(	(	-LRB-
cord-006860-a3b8hyyr	104	6	12	12	CD
cord-006860-a3b8hyyr	104	7	males	male	NNS
cord-006860-a3b8hyyr	104	8	[	[	-LRB-
cord-006860-a3b8hyyr	104	9	m	m	NNP
cord-006860-a3b8hyyr	104	10	]	]	-RRB-
cord-006860-a3b8hyyr	104	11	,	,	,
cord-006860-a3b8hyyr	104	12	17	17	CD
cord-006860-a3b8hyyr	104	13	females	female	NNS
cord-006860-a3b8hyyr	104	14	It	-PRON-	PRP
cord-006860-a3b8hyyr	104	15	]	]	-RRB-
cord-006860-a3b8hyyr	104	16	)	)	-RRB-
cord-006860-a3b8hyyr	104	17	in	in	IN
cord-006860-a3b8hyyr	104	18	whom	whom	WP
cord-006860-a3b8hyyr	104	19	a	a	DT
cord-006860-a3b8hyyr	104	20	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	104	21	mutation	mutation	NN
cord-006860-a3b8hyyr	104	22	had	have	VBD
cord-006860-a3b8hyyr	104	23	been	be	VBN
cord-006860-a3b8hyyr	104	24	verified	verify	VBN
cord-006860-a3b8hyyr	104	25	by	by	IN
cord-006860-a3b8hyyr	104	26	DNA	dna	NN
cord-006860-a3b8hyyr	104	27	analysis	analysis	NN
cord-006860-a3b8hyyr	104	28	.	.	.
cord-006860-a3b8hyyr	105	1	The	the	DT
cord-006860-a3b8hyyr	105	2	median	median	JJ
cord-006860-a3b8hyyr	105	3	age	age	NN
cord-006860-a3b8hyyr	105	4	at	at	IN
cord-006860-a3b8hyyr	105	5	the	the	DT
cord-006860-a3b8hyyr	105	6	time	time	NN
cord-006860-a3b8hyyr	105	7	of	of	IN
cord-006860-a3b8hyyr	105	8	the	the	DT
cord-006860-a3b8hyyr	105	9	study	study	NN
cord-006860-a3b8hyyr	105	10	was	be	VBD
cord-006860-a3b8hyyr	105	11	38.8	38.8	CD
cord-006860-a3b8hyyr	105	12	years	year	NNS
cord-006860-a3b8hyyr	105	13	(	(	-LRB-
cord-006860-a3b8hyyr	105	14	y	y	NN
cord-006860-a3b8hyyr	105	15	)	)	-RRB-
cord-006860-a3b8hyyr	106	1	(	(	-LRB-
cord-006860-a3b8hyyr	106	2	range	range	NNP
cord-006860-a3b8hyyr	106	3	9	9	CD
cord-006860-a3b8hyyr	106	4	-	-	SYM
cord-006860-a3b8hyyr	106	5	83	83	CD
cord-006860-a3b8hyyr	106	6	y	y	NN
cord-006860-a3b8hyyr	106	7	)	)	-RRB-
cord-006860-a3b8hyyr	106	8	.	.	.
cord-006860-a3b8hyyr	107	1	Twenty	twenty	CD
cord-006860-a3b8hyyr	107	2	-	-	HYPH
cord-006860-a3b8hyyr	107	3	five	five	CD
cord-006860-a3b8hyyr	107	4	patients	patient	NNS
cord-006860-a3b8hyyr	107	5	had	have	VBD
cord-006860-a3b8hyyr	107	6	experienced	experience	VBN
cord-006860-a3b8hyyr	107	7	VT	VT	NNP
cord-006860-a3b8hyyr	107	8	(	(	-LRB-
cord-006860-a3b8hyyr	107	9	10	10	CD
cord-006860-a3b8hyyr	107	10	m	m	NN
cord-006860-a3b8hyyr	107	11	,	,	,
cord-006860-a3b8hyyr	107	12	15	15	CD
cord-006860-a3b8hyyr	107	13	f	f	NNP
cord-006860-a3b8hyyr	107	14	)	)	-RRB-
cord-006860-a3b8hyyr	107	15	.	.	.
cord-006860-a3b8hyyr	108	1	Four	four	CD
cord-006860-a3b8hyyr	108	2	patients	patient	NNS
cord-006860-a3b8hyyr	108	3	were	be	VBD
cord-006860-a3b8hyyr	108	4	discovered	discover	VBN
cord-006860-a3b8hyyr	108	5	dunng	dunng	JJ
cord-006860-a3b8hyyr	108	6	family	family	NN
cord-006860-a3b8hyyr	108	7	studies	study	NNS
cord-006860-a3b8hyyr	108	8	and	and	CC
cord-006860-a3b8hyyr	108	9	were	be	VBD
cord-006860-a3b8hyyr	108	10	asymptomatic	asymptomatic	JJ
cord-006860-a3b8hyyr	108	11	,	,	,
cord-006860-a3b8hyyr	108	12	three	three	CD
cord-006860-a3b8hyyr	108	13	were	be	VBD
cord-006860-a3b8hyyr	108	14	children	child	NNS
cord-006860-a3b8hyyr	108	15	(	(	-LRB-
cord-006860-a3b8hyyr	108	16	between	between	IN
cord-006860-a3b8hyyr	108	17	9	9	CD
cord-006860-a3b8hyyr	108	18	and	and	CC
cord-006860-a3b8hyyr	108	19	13	13	CD
cord-006860-a3b8hyyr	108	20	y	y	NNP
cord-006860-a3b8hyyr	108	21	)	)	-RRB-
cord-006860-a3b8hyyr	108	22	and	and	CC
cord-006860-a3b8hyyr	108	23	one	one	CD
cord-006860-a3b8hyyr	108	24	patient	patient	NN
cord-006860-a3b8hyyr	108	25	was	be	VBD
cord-006860-a3b8hyyr	108	26	a	a	DT
cord-006860-a3b8hyyr	108	27	62	62	CD
cord-006860-a3b8hyyr	108	28	y	y	NNP
cord-006860-a3b8hyyr	108	29	old	old	JJ
cord-006860-a3b8hyyr	108	30	man	man	NN
cord-006860-a3b8hyyr	108	31	.	.	.
cord-006860-a3b8hyyr	109	1	In	in	IN
cord-006860-a3b8hyyr	109	2	males	male	NNS
cord-006860-a3b8hyyr	109	3	the	the	DT
cord-006860-a3b8hyyr	109	4	first	first	JJ
cord-006860-a3b8hyyr	109	5	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	109	6	occurred	occur	VBD
cord-006860-a3b8hyyr	109	7	at	at	IN
cord-006860-a3b8hyyr	109	8	a	a	DT
cord-006860-a3b8hyyr	109	9	median	median	JJ
cord-006860-a3b8hyyr	109	10	age	age	NN
cord-006860-a3b8hyyr	109	11	of	of	IN
cord-006860-a3b8hyyr	109	12	38	38	CD
cord-006860-a3b8hyyr	109	13	y	y	NN
cord-006860-a3b8hyyr	109	14	(	(	-LRB-
cord-006860-a3b8hyyr	109	15	range	range	NNP
cord-006860-a3b8hyyr	109	16	21	21	CD
cord-006860-a3b8hyyr	109	17	-	-	SYM
cord-006860-a3b8hyyr	109	18	82	82	CD
cord-006860-a3b8hyyr	109	19	y	y	NNP
cord-006860-a3b8hyyr	109	20	)	)	-RRB-
cord-006860-a3b8hyyr	109	21	,	,	,
cord-006860-a3b8hyyr	109	22	in	in	IN
cord-006860-a3b8hyyr	109	23	females	female	NNS
cord-006860-a3b8hyyr	109	24	this	this	DT
cord-006860-a3b8hyyr	109	25	was	be	VBD
cord-006860-a3b8hyyr	109	26	at	at	IN
cord-006860-a3b8hyyr	109	27	a	a	DT
cord-006860-a3b8hyyr	109	28	significantly	significantly	RB
cord-006860-a3b8hyyr	109	29	younger	young	JJR
cord-006860-a3b8hyyr	109	30	median	median	NN
cord-006860-a3b8hyyr	109	31	age	age	NN
cord-006860-a3b8hyyr	109	32	of	of	IN
cord-006860-a3b8hyyr	109	33	26	26	CD
cord-006860-a3b8hyyr	109	34	y	y	NN
cord-006860-a3b8hyyr	109	35	(	(	-LRB-
cord-006860-a3b8hyyr	109	36	range	range	NNP
cord-006860-a3b8hyyr	109	37	17	17	CD
cord-006860-a3b8hyyr	109	38	-	-	SYM
cord-006860-a3b8hyyr	109	39	49	49	CD
cord-006860-a3b8hyyr	109	40	y	y	NNP
cord-006860-a3b8hyyr	109	41	)	)	-RRB-
cord-006860-a3b8hyyr	109	42	.	.	.
cord-006860-a3b8hyyr	110	1	Twelve	twelve	CD
cord-006860-a3b8hyyr	110	2	of	of	IN
cord-006860-a3b8hyyr	110	3	the	the	DT
cord-006860-a3b8hyyr	110	4	15	15	CD
cord-006860-a3b8hyyr	110	5	symptomatic	symptomatic	JJ
cord-006860-a3b8hyyr	110	6	females	female	NNS
cord-006860-a3b8hyyr	110	7	had	have	VBD
cord-006860-a3b8hyyr	110	8	taken	take	VBN
cord-006860-a3b8hyyr	110	9	oral	oral	JJ
cord-006860-a3b8hyyr	110	10	contraceptives	contraceptive	NNS
cord-006860-a3b8hyyr	110	11	(	(	-LRB-
cord-006860-a3b8hyyr	110	12	OC	OC	NNP
cord-006860-a3b8hyyr	110	13	,	,	,
cord-006860-a3b8hyyr	110	14	estregen	estregen	NN
cord-006860-a3b8hyyr	110	15	content	content	NN
cord-006860-a3b8hyyr	110	16	0.02-0.ling	0.02-0.le	VBG
cord-006860-a3b8hyyr	110	17	)	)	-RRB-
cord-006860-a3b8hyyr	110	18	for	for	IN
cord-006860-a3b8hyyr	110	19	6	6	CD
cord-006860-a3b8hyyr	110	20	to	to	TO
cord-006860-a3b8hyyr	110	21	150	150	CD
cord-006860-a3b8hyyr	110	22	months	month	NNS
cord-006860-a3b8hyyr	110	23	(	(	-LRB-
cord-006860-a3b8hyyr	110	24	median	median	NN
cord-006860-a3b8hyyr	110	25	71	71	CD
cord-006860-a3b8hyyr	110	26	m	m	CD
cord-006860-a3b8hyyr	110	27	)	)	-RRB-
cord-006860-a3b8hyyr	110	28	pdor	pdor	NNP
cord-006860-a3b8hyyr	110	29	to	to	IN
cord-006860-a3b8hyyr	110	30	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	110	31	.	.	.
cord-006860-a3b8hyyr	111	1	In	in	IN
cord-006860-a3b8hyyr	111	2	2	2	CD
cord-006860-a3b8hyyr	111	3	women	woman	NNS
cord-006860-a3b8hyyr	111	4	VT	VT	NNP
cord-006860-a3b8hyyr	111	5	occurred	occur	VBD
cord-006860-a3b8hyyr	111	6	during	during	IN
cord-006860-a3b8hyyr	111	7	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	111	8	,	,	,
cord-006860-a3b8hyyr	111	9	in	in	IN
cord-006860-a3b8hyyr	111	10	1	1	CD
cord-006860-a3b8hyyr	111	11	female	female	NN
cord-006860-a3b8hyyr	111	12	it	-PRON-	PRP
cord-006860-a3b8hyyr	111	13	was	be	VBD
cord-006860-a3b8hyyr	111	14	precipitated	precipitate	VBN
cord-006860-a3b8hyyr	111	15	by	by	IN
cord-006860-a3b8hyyr	111	16	hormone	hormone	NN
cord-006860-a3b8hyyr	111	17	replacement	replacement	NN
cord-006860-a3b8hyyr	111	18	therapy	therapy	NN
cord-006860-a3b8hyyr	111	19	.	.	.
cord-006860-a3b8hyyr	112	1	In	in	IN
cord-006860-a3b8hyyr	112	2	contrast	contrast	NN
cord-006860-a3b8hyyr	112	3	,	,	,
cord-006860-a3b8hyyr	112	4	in	in	IN
cord-006860-a3b8hyyr	112	5	8,<10	8,<10	CD
cord-006860-a3b8hyyr	112	6	males	male	NNS
cord-006860-a3b8hyyr	112	7	the	the	DT
cord-006860-a3b8hyyr	112	8	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	112	9	happened	happen	VBD
cord-006860-a3b8hyyr	112	10	spontaneously	spontaneously	RB
cord-006860-a3b8hyyr	112	11	,	,	,
cord-006860-a3b8hyyr	112	12	in	in	IN
cord-006860-a3b8hyyr	112	13	2	2	CD
cord-006860-a3b8hyyr	112	14	males	male	NNS
cord-006860-a3b8hyyr	112	15	it	-PRON-	PRP
cord-006860-a3b8hyyr	112	16	followed	follow	VBD
cord-006860-a3b8hyyr	112	17	surgery	surgery	NN
cord-006860-a3b8hyyr	112	18	.	.	.
cord-006860-a3b8hyyr	113	1	The	the	DT
cord-006860-a3b8hyyr	113	2	sites	site	NNS
cord-006860-a3b8hyyr	113	3	of	of	IN
cord-006860-a3b8hyyr	113	4	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	113	5	were	be	VBD
cord-006860-a3b8hyyr	113	6	DVT	DVT	NNP
cord-006860-a3b8hyyr	113	7	in	in	IN
cord-006860-a3b8hyyr	113	8	9	9	CD
cord-006860-a3b8hyyr	113	9	males	male	NNS
cord-006860-a3b8hyyr	113	10	and	and	CC
cord-006860-a3b8hyyr	113	11	14	14	CD
cord-006860-a3b8hyyr	113	12	females	female	NNS
cord-006860-a3b8hyyr	113	13	,	,	,
cord-006860-a3b8hyyr	113	14	DVT	DVT	NNP
cord-006860-a3b8hyyr	113	15	and	and	CC
cord-006860-a3b8hyyr	113	16	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	113	17	embolism	embolism	NN
cord-006860-a3b8hyyr	113	18	(	(	-LRB-
cord-006860-a3b8hyyr	113	19	PE	PE	NNP
cord-006860-a3b8hyyr	113	20	)	)	-RRB-
cord-006860-a3b8hyyr	113	21	in	in	IN
cord-006860-a3b8hyyr	113	22	4	4	CD
cord-006860-a3b8hyyr	113	23	females	female	NNS
cord-006860-a3b8hyyr	113	24	and	and	CC
cord-006860-a3b8hyyr	113	25	1	1	CD
cord-006860-a3b8hyyr	113	26	male	male	NN
cord-006860-a3b8hyyr	113	27	,	,	,
cord-006860-a3b8hyyr	113	28	DVT	DVT	NNP
cord-006860-a3b8hyyr	113	29	and	and	CC
cord-006860-a3b8hyyr	113	30	caval	caval	NNP
cord-006860-a3b8hyyr	113	31	vein	vein	NN
cord-006860-a3b8hyyr	113	32	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	113	33	in	in	IN
cord-006860-a3b8hyyr	113	34	1	1	CD
cord-006860-a3b8hyyr	113	35	female	female	JJ
cord-006860-a3b8hyyr	113	36	and	and	CC
cord-006860-a3b8hyyr	113	37	superficial	superficial	JJ
cord-006860-a3b8hyyr	113	38	thrombophlebitis	thrombophlebitis	NN
cord-006860-a3b8hyyr	113	39	in	in	IN
cord-006860-a3b8hyyr	113	40	4	4	CD
cord-006860-a3b8hyyr	113	41	males	male	NNS
cord-006860-a3b8hyyr	113	42	and	and	CC
cord-006860-a3b8hyyr	113	43	1	1	CD
cord-006860-a3b8hyyr	113	44	female	female	NN
cord-006860-a3b8hyyr	113	45	.	.	.
cord-006860-a3b8hyyr	114	1	Eight	eight	CD
cord-006860-a3b8hyyr	114	2	females	female	NNS
cord-006860-a3b8hyyr	114	3	had	have	VBD
cord-006860-a3b8hyyr	114	4	at	at	RB
cord-006860-a3b8hyyr	114	5	least	least	RBS
cord-006860-a3b8hyyr	114	6	one	one	CD
cord-006860-a3b8hyyr	114	7	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	114	8	,	,	,
cord-006860-a3b8hyyr	114	9	in	in	IN
cord-006860-a3b8hyyr	114	10	total	total	JJ
cord-006860-a3b8hyyr	114	11	11	11	CD
cord-006860-a3b8hyyr	114	12	children	child	NNS
cord-006860-a3b8hyyr	114	13	and	and	CC
cord-006860-a3b8hyyr	114	14	5	5	CD
cord-006860-a3b8hyyr	114	15	abortions	abortion	NNS
cord-006860-a3b8hyyr	114	16	.	.	.
cord-006860-a3b8hyyr	115	1	Two	two	CD
cord-006860-a3b8hyyr	115	2	had	have	VBD
cord-006860-a3b8hyyr	115	3	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	115	4	events	event	NNS
cord-006860-a3b8hyyr	115	5	during	during	IN
cord-006860-a3b8hyyr	115	6	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	115	7	and	and	CC
cord-006860-a3b8hyyr	115	8	2	2	CD
cord-006860-a3b8hyyr	115	9	after	after	IN
cord-006860-a3b8hyyr	115	10	delivery	delivery	NN
cord-006860-a3b8hyyr	115	11	.	.	.
cord-006860-a3b8hyyr	116	1	All	all	DT
cord-006860-a3b8hyyr	116	2	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	116	3	patients	patient	NNS
cord-006860-a3b8hyyr	116	4	showed	show	VBD
cord-006860-a3b8hyyr	116	5	APC	APC	NNP
cord-006860-a3b8hyyr	116	6	ratios	ratio	NNS
cord-006860-a3b8hyyr	116	7	between	between	IN
cord-006860-a3b8hyyr	116	8	1.12	1.12	CD
cord-006860-a3b8hyyr	116	9	and	and	CC
cord-006860-a3b8hyyr	116	10	1.68	1.68	CD
cord-006860-a3b8hyyr	116	11	(	(	-LRB-
cord-006860-a3b8hyyr	116	12	mean	mean	VBP
cord-006860-a3b8hyyr	116	13	1.39	1.39	CD
cord-006860-a3b8hyyr	116	14	+	+	SYM
cord-006860-a3b8hyyr	116	15	0.19	0.19	CD
cord-006860-a3b8hyyr	116	16	)	)	-RRB-
cord-006860-a3b8hyyr	116	17	.	.	.
cord-006860-a3b8hyyr	117	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	117	2	:	:	:
cord-006860-a3b8hyyr	117	3	Patients	patient	NNS
cord-006860-a3b8hyyr	117	4	with	with	IN
cord-006860-a3b8hyyr	117	5	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	117	6	FV	FV	NNP
cord-006860-a3b8hyyr	117	7	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	117	8	have	have	VBP
cord-006860-a3b8hyyr	117	9	similar	similar	JJ
cord-006860-a3b8hyyr	117	10	clinical	clinical	JJ
cord-006860-a3b8hyyr	117	11	symptoms	symptom	NNS
cord-006860-a3b8hyyr	117	12	as	as	IN
cord-006860-a3b8hyyr	117	13	patients	patient	NNS
cord-006860-a3b8hyyr	117	14	with	with	IN
cord-006860-a3b8hyyr	117	15	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	117	16	of	of	IN
cord-006860-a3b8hyyr	117	17	antithrombin-	antithrombin-	NN
cord-006860-a3b8hyyr	117	18	,	,	,
cord-006860-a3b8hyyr	117	19	protein	protein	NN
cord-006860-a3b8hyyr	117	20	C	c	NN
cord-006860-a3b8hyyr	117	21	or	or	CC
cord-006860-a3b8hyyr	117	22	protein	protein	NN
cord-006860-a3b8hyyr	117	23	S	S	NNP
cord-006860-a3b8hyyr	117	24	deficiency	deficiency	NN
cord-006860-a3b8hyyr	117	25	.	.	.
cord-006860-a3b8hyyr	118	1	However	however	RB
cord-006860-a3b8hyyr	118	2	,	,	,
cord-006860-a3b8hyyr	118	3	in	in	IN
cord-006860-a3b8hyyr	118	4	contrast	contrast	NN
cord-006860-a3b8hyyr	118	5	to	to	IN
cord-006860-a3b8hyyr	118	6	these	these	DT
cord-006860-a3b8hyyr	118	7	defects	defect	NNS
cord-006860-a3b8hyyr	118	8	a	a	DT
cord-006860-a3b8hyyr	118	9	very	very	RB
cord-006860-a3b8hyyr	118	10	high	high	JJ
cord-006860-a3b8hyyr	118	11	dsk	dsk	NNP
cord-006860-a3b8hyyr	118	12	dudng	dudng	NNP
cord-006860-a3b8hyyr	118	13	oral	oral	JJ
cord-006860-a3b8hyyr	118	14	contraceptive	contraceptive	JJ
cord-006860-a3b8hyyr	118	15	medication	medication	NN
cord-006860-a3b8hyyr	118	16	leading	lead	VBG
cord-006860-a3b8hyyr	118	17	to	to	IN
cord-006860-a3b8hyyr	118	18	an	an	DT
cord-006860-a3b8hyyr	118	19	ealier	eali	JJR
cord-006860-a3b8hyyr	118	20	manifestation	manifestation	NN
cord-006860-a3b8hyyr	118	21	in	in	IN
cord-006860-a3b8hyyr	118	22	females	female	NNS
cord-006860-a3b8hyyr	118	23	can	can	MD
cord-006860-a3b8hyyr	118	24	be	be	VB
cord-006860-a3b8hyyr	118	25	observed	observe	VBN
cord-006860-a3b8hyyr	118	26	.	.	.
cord-006860-a3b8hyyr	119	1	Several	several	JJ
cord-006860-a3b8hyyr	119	2	synthetic	synthetic	NN
cord-006860-a3b8hyyr	119	3	(	(	-LRB-
cord-006860-a3b8hyyr	119	4	efegatran	efegatran	NN
cord-006860-a3b8hyyr	119	5	,	,	,
cord-006860-a3b8hyyr	119	6	argatroban	argatroban	NNP
cord-006860-a3b8hyyr	119	7	,	,	,
cord-006860-a3b8hyyr	119	8	inogatran	inogatran	NNP
cord-006860-a3b8hyyr	119	9	and	and	CC
cord-006860-a3b8hyyr	119	10	napsagatran	napsagatran	NNP
cord-006860-a3b8hyyr	119	11	)	)	-RRB-
cord-006860-a3b8hyyr	119	12	and	and	CC
cord-006860-a3b8hyyr	119	13	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	119	14	(	(	-LRB-
cord-006860-a3b8hyyr	119	15	hirudin	hirudin	NN
cord-006860-a3b8hyyr	119	16	,	,	,
cord-006860-a3b8hyyr	119	17	PEG	PEG	NNP
cord-006860-a3b8hyyr	119	18	-	-	HYPH
cord-006860-a3b8hyyr	119	19	hirudin	hirudin	NN
cord-006860-a3b8hyyr	119	20	and	and	CC
cord-006860-a3b8hyyr	119	21	hirulog	hirulog	NN
cord-006860-a3b8hyyr	119	22	)	)	-RRB-
cord-006860-a3b8hyyr	120	1	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	120	2	agents	agent	NNS
cord-006860-a3b8hyyr	120	3	are	be	VBP
cord-006860-a3b8hyyr	120	4	in	in	IN
cord-006860-a3b8hyyr	120	5	different	different	JJ
cord-006860-a3b8hyyr	120	6	stages	stage	NNS
cord-006860-a3b8hyyr	120	7	of	of	IN
cord-006860-a3b8hyyr	120	8	nlinical	nlinical	JJ
cord-006860-a3b8hyyr	120	9	development	development	NN
cord-006860-a3b8hyyr	120	10	for	for	IN
cord-006860-a3b8hyyr	120	11	cardiovascular	cardiovascular	JJ
cord-006860-a3b8hyyr	120	12	and	and	CC
cord-006860-a3b8hyyr	120	13	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	120	14	indications	indication	NNS
cord-006860-a3b8hyyr	120	15	.	.	.
cord-006860-a3b8hyyr	121	1	While	while	IN
cord-006860-a3b8hyyr	121	2	the	the	DT
cord-006860-a3b8hyyr	121	3	specificity	specificity	NN
cord-006860-a3b8hyyr	121	4	of	of	IN
cord-006860-a3b8hyyr	121	5	these	these	DT
cord-006860-a3b8hyyr	121	6	agents	agent	NNS
cord-006860-a3b8hyyr	121	7	for	for	IN
cord-006860-a3b8hyyr	121	8	thrombin	thrombin	NN
cord-006860-a3b8hyyr	121	9	is	be	VBZ
cord-006860-a3b8hyyr	121	10	a	a	DT
cord-006860-a3b8hyyr	121	11	concern	concern	NN
cord-006860-a3b8hyyr	121	12	,	,	,
cord-006860-a3b8hyyr	121	13	little	little	JJ
cord-006860-a3b8hyyr	121	14	has	have	VBZ
cord-006860-a3b8hyyr	121	15	been	be	VBN
cord-006860-a3b8hyyr	121	16	done	do	VBN
cord-006860-a3b8hyyr	121	17	to	to	TO
cord-006860-a3b8hyyr	121	18	study	study	VB
cord-006860-a3b8hyyr	121	19	the	the	DT
cord-006860-a3b8hyyr	121	20	effects	effect	NNS
cord-006860-a3b8hyyr	121	21	of	of	IN
cord-006860-a3b8hyyr	121	22	these	these	DT
cord-006860-a3b8hyyr	121	23	agents	agent	NNS
cord-006860-a3b8hyyr	121	24	on	on	IN
cord-006860-a3b8hyyr	121	25	other	other	JJ
cord-006860-a3b8hyyr	121	26	serine	serine	NN
cord-006860-a3b8hyyr	121	27	proteases	protease	NNS
cord-006860-a3b8hyyr	121	28	involved	involve	VBN
cord-006860-a3b8hyyr	121	29	in	in	IN
cord-006860-a3b8hyyr	121	30	coagulation	coagulation	NN
cord-006860-a3b8hyyr	121	31	and	and	CC
cord-006860-a3b8hyyr	121	32	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	121	33	processes	process	NNS
cord-006860-a3b8hyyr	121	34	.	.	.
cord-006860-a3b8hyyr	122	1	Fihrinolytic	fihrinolytic	JJ
cord-006860-a3b8hyyr	122	2	compromise	compromise	NN
cord-006860-a3b8hyyr	122	3	by	by	IN
cord-006860-a3b8hyyr	122	4	site	site	NN
cord-006860-a3b8hyyr	122	5	directed	direct	VBN
cord-006860-a3b8hyyr	122	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	122	7	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	122	8	has	have	VBZ
cord-006860-a3b8hyyr	122	9	been	be	VBN
cord-006860-a3b8hyyr	122	10	reported	report	VBN
cord-006860-a3b8hyyr	122	11	recently	recently	RB
cord-006860-a3b8hyyr	122	12	(	(	-LRB-
cord-006860-a3b8hyyr	122	13	Thromb	Thromb	NNP
cord-006860-a3b8hyyr	122	14	Res	Res	NNP
cord-006860-a3b8hyyr	122	15	74(3	74(3	NN
cord-006860-a3b8hyyr	122	16	)	)	-RRB-
cord-006860-a3b8hyyr	122	17	:	:	:
cord-006860-a3b8hyyr	122	18	193	193	CD
cord-006860-a3b8hyyr	122	19	-	-	SYM
cord-006860-a3b8hyyr	122	20	205	205	CD
cord-006860-a3b8hyyr	122	21	,	,	,
cord-006860-a3b8hyyr	122	22	1994	1994	CD
cord-006860-a3b8hyyr	122	23	)	)	-RRB-
cord-006860-a3b8hyyr	122	24	.	.	.
cord-006860-a3b8hyyr	123	1	While	while	IN
cord-006860-a3b8hyyr	123	2	these	these	DT
cord-006860-a3b8hyyr	123	3	agents	agent	NNS
cord-006860-a3b8hyyr	123	4	have	have	VBP
cord-006860-a3b8hyyr	123	5	been	be	VBN
cord-006860-a3b8hyyr	123	6	shown	show	VBN
cord-006860-a3b8hyyr	123	7	to	to	TO
cord-006860-a3b8hyyr	123	8	inhibit	inhibit	VB
cord-006860-a3b8hyyr	123	9	plasmin	plasmin	JJ
cord-006860-a3b8hyyr	123	10	and	and	CC
cord-006860-a3b8hyyr	123	11	related	related	JJ
cord-006860-a3b8hyyr	123	12	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	123	13	,	,	,
cord-006860-a3b8hyyr	123	14	little	little	JJ
cord-006860-a3b8hyyr	123	15	or	or	CC
cord-006860-a3b8hyyr	123	16	no	no	DT
cord-006860-a3b8hyyr	123	17	informatienentheir	informatienentheir	FW
cord-006860-a3b8hyyr	123	18	effects	effect	NNS
cord-006860-a3b8hyyr	124	1	onthe	onthe	JJ
cord-006860-a3b8hyyr	124	2	generation	generation	NN
cord-006860-a3b8hyyr	124	3	and	and	CC
cord-006860-a3b8hyyr	124	4	functionality	functionality	NN
cord-006860-a3b8hyyr	124	5	of	of	IN
cord-006860-a3b8hyyr	124	6	APC	APC	NNP
cord-006860-a3b8hyyr	124	7	is	be	VBZ
cord-006860-a3b8hyyr	124	8	available	available	JJ
cord-006860-a3b8hyyr	124	9	.	.	.
cord-006860-a3b8hyyr	125	1	SinceAPC	SinceAPC	.
cord-006860-a3b8hyyr	126	1	plays	play	VBZ
cord-006860-a3b8hyyr	126	2	an	an	DT
cord-006860-a3b8hyyr	126	3	increasingly	increasingly	RB
cord-006860-a3b8hyyr	126	4	important	important	JJ
cord-006860-a3b8hyyr	126	5	role	role	NN
cord-006860-a3b8hyyr	126	6	both	both	DT
cord-006860-a3b8hyyr	126	7	as	as	IN
cord-006860-a3b8hyyr	126	8	an	an	DT
cord-006860-a3b8hyyr	126	9	antienagulant	antienagulant	JJ
cord-006860-a3b8hyyr	126	10	enzyme	enzyme	NN
cord-006860-a3b8hyyr	126	11	,	,	,
cord-006860-a3b8hyyr	126	12	by	by	IN
cord-006860-a3b8hyyr	126	13	inhibiting	inhibit	VBG
cord-006860-a3b8hyyr	126	14	factors	factor	NNS
cord-006860-a3b8hyyr	126	15	V	v	NN
cord-006860-a3b8hyyr	126	16	and	and	CC
cord-006860-a3b8hyyr	126	17	VIII	VIII	NNP
cord-006860-a3b8hyyr	126	18	,	,	,
cord-006860-a3b8hyyr	126	19	end	end	VB
cord-006860-a3b8hyyr	126	20	a	a	DT
cord-006860-a3b8hyyr	126	21	pro	pro	JJ
cord-006860-a3b8hyyr	126	22	-	-	JJ
cord-006860-a3b8hyyr	126	23	fibrinelytic	fibrinelytic	JJ
cord-006860-a3b8hyyr	126	24	enzyme	enzyme	NN
cord-006860-a3b8hyyr	126	25	,	,	,
cord-006860-a3b8hyyr	126	26	by	by	IN
cord-006860-a3b8hyyr	126	27	stimulating	stimulate	VBG
cord-006860-a3b8hyyr	126	28	the	the	DT
cord-006860-a3b8hyyr	126	29	release	release	NN
cord-006860-a3b8hyyr	126	30	of	of	IN
cord-006860-a3b8hyyr	126	31	t	t	NNP
cord-006860-a3b8hyyr	126	32	-	-	HYPH
cord-006860-a3b8hyyr	126	33	PA	PA	NNP
cord-006860-a3b8hyyr	126	34	fi'om	fi'om	NN
cord-006860-a3b8hyyr	126	35	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	126	36	sites	site	NNS
cord-006860-a3b8hyyr	126	37	,	,	,
cord-006860-a3b8hyyr	126	38	an	an	DT
cord-006860-a3b8hyyr	126	39	inhibition	inhibition	NN
cord-006860-a3b8hyyr	126	40	of	of	IN
cord-006860-a3b8hyyr	126	41	APC	APC	NNP
cord-006860-a3b8hyyr	126	42	may	may	MD
cord-006860-a3b8hyyr	126	43	result	result	VB
cord-006860-a3b8hyyr	126	44	in	in	IN
cord-006860-a3b8hyyr	126	45	both	both	DT
cord-006860-a3b8hyyr	126	46	pro	pro	JJ
cord-006860-a3b8hyyr	126	47	-	-	JJ
cord-006860-a3b8hyyr	126	48	coagulant	coagulant	JJ
cord-006860-a3b8hyyr	126	49	state	state	NN
cord-006860-a3b8hyyr	126	50	and	and	CC
cord-006860-a3b8hyyr	126	51	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	126	52	deficit	deficit	NN
cord-006860-a3b8hyyr	126	53	.	.	.
cord-006860-a3b8hyyr	127	1	Representative	representative	JJ
cord-006860-a3b8hyyr	127	2	thrombin	thrombin	NN
cord-006860-a3b8hyyr	127	3	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	127	4	(	(	-LRB-
cord-006860-a3b8hyyr	127	5	DuP	dup	VBP
cord-006860-a3b8hyyr	127	6	714	714	CD
cord-006860-a3b8hyyr	127	7	-a	-a	HYPH
cord-006860-a3b8hyyr	127	8	prototype	prototype	NN
cord-006860-a3b8hyyr	127	9	boronic	boronic	NNP
cord-006860-a3b8hyyr	127	10	acid	acid	NN
cord-006860-a3b8hyyr	127	11	peptide	peptide	NN
cord-006860-a3b8hyyr	127	12	derivative	derivative	NN
cord-006860-a3b8hyyr	127	13	,	,	,
cord-006860-a3b8hyyr	127	14	efega	efega	NNP
cord-006860-a3b8hyyr	127	15	~	~	NFP
cord-006860-a3b8hyyr	127	16	an	an	DT
cord-006860-a3b8hyyr	127	17	,	,	,
cord-006860-a3b8hyyr	127	18	argatroban	argatroban	NNP
cord-006860-a3b8hyyr	127	19	,	,	,
cord-006860-a3b8hyyr	127	20	hirulog	hirulog	NNP
cord-006860-a3b8hyyr	127	21	,	,	,
cord-006860-a3b8hyyr	127	22	hirudin	hirudin	NN
cord-006860-a3b8hyyr	127	23	and	and	CC
cord-006860-a3b8hyyr	127	24	FEG	FEG	NNP
cord-006860-a3b8hyyr	127	25	-	-	HYPH
cord-006860-a3b8hyyr	127	26	hirudin	hirudin	NN
cord-006860-a3b8hyyr	127	27	)	)	-RRB-
cord-006860-a3b8hyyr	127	28	have	have	VBP
cord-006860-a3b8hyyr	127	29	been	be	VBN
cord-006860-a3b8hyyr	127	30	compared	compare	VBN
cord-006860-a3b8hyyr	127	31	for	for	IN
cord-006860-a3b8hyyr	127	32	their	-PRON-	PRP$
cord-006860-a3b8hyyr	127	33	ability	ability	NN
cord-006860-a3b8hyyr	127	34	to	to	TO
cord-006860-a3b8hyyr	127	35	inhibit	inhibit	VB
cord-006860-a3b8hyyr	127	36	APC	APC	NNP
cord-006860-a3b8hyyr	127	37	(	(	-LRB-
cord-006860-a3b8hyyr	127	38	American	American	NNP
cord-006860-a3b8hyyr	127	39	Red	Red	NNP
cord-006860-a3b8hyyr	127	40	Cross	Cross	NNP
cord-006860-a3b8hyyr	127	41	)	)	-RRB-
cord-006860-a3b8hyyr	127	42	.	.	.
cord-006860-a3b8hyyr	128	1	These	these	DT
cord-006860-a3b8hyyr	128	2	bionhemically	bionhemically	RB
cord-006860-a3b8hyyr	128	3	defined	define	VBD
cord-006860-a3b8hyyr	128	4	studies	study	NNS
cord-006860-a3b8hyyr	128	5	in	in	IN
cord-006860-a3b8hyyr	128	6	which	which	WDT
cord-006860-a3b8hyyr	128	7	the	the	DT
cord-006860-a3b8hyyr	128	8	remaining	remain	VBG
cord-006860-a3b8hyyr	128	9	activity	activity	NN
cord-006860-a3b8hyyr	128	10	of	of	IN
cord-006860-a3b8hyyr	128	11	APC	APC	NNP
cord-006860-a3b8hyyr	128	12	after	after	IN
cord-006860-a3b8hyyr	128	13	incubation	incubation	NN
cord-006860-a3b8hyyr	128	14	with	with	IN
cord-006860-a3b8hyyr	128	15	a	a	DT
cord-006860-a3b8hyyr	128	16	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	128	17	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	128	18	was	be	VBD
cord-006860-a3b8hyyr	128	19	determined	determine	VBN
cord-006860-a3b8hyyr	128	20	speclrophotometrically	speclrophotometrically	RB
cord-006860-a3b8hyyr	128	21	with	with	IN
cord-006860-a3b8hyyr	128	22	a	a	DT
cord-006860-a3b8hyyr	128	23	ehromogenic	ehromogenic	JJ
cord-006860-a3b8hyyr	128	24	substrate	substrate	NN
cord-006860-a3b8hyyr	128	25	(	(	-LRB-
cord-006860-a3b8hyyr	128	26	S-2288	S-2288	NNP
cord-006860-a3b8hyyr	128	27	,	,	,
cord-006860-a3b8hyyr	128	28	Pharmacia	Pharmacia	NNP
cord-006860-a3b8hyyr	128	29	,	,	,
cord-006860-a3b8hyyr	128	30	Franklin	Franklin	NNP
cord-006860-a3b8hyyr	128	31	,	,	,
cord-006860-a3b8hyyr	128	32	OH	OH	NNP
cord-006860-a3b8hyyr	128	33	)	)	-RRB-
cord-006860-a3b8hyyr	128	34	,	,	,
cord-006860-a3b8hyyr	128	35	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	128	36	that	that	IN
cord-006860-a3b8hyyr	128	37	DuP	DuP	VBZ
cord-006860-a3b8hyyr	128	38	714	714	CD
cord-006860-a3b8hyyr	128	39	and	and	CC
cord-006860-a3b8hyyr	128	40	efegatran	efegatran	NNP
cord-006860-a3b8hyyr	128	41	inhibit	inhibit	VBP
cord-006860-a3b8hyyr	128	42	APC	APC	NNP
cord-006860-a3b8hyyr	128	43	in	in	IN
cord-006860-a3b8hyyr	128	44	a	a	DT
cord-006860-a3b8hyyr	128	45	coneentrafinn	coneentrafinn	NNP
cord-006860-a3b8hyyr	128	46	dependent	dependent	JJ
cord-006860-a3b8hyyr	128	47	manner	manner	NN
cord-006860-a3b8hyyr	128	48	(	(	-LRB-
cord-006860-a3b8hyyr	129	1	IC~0=0.75	IC~0=0.75	NNP
cord-006860-a3b8hyyr	129	2	and	and	CC
cord-006860-a3b8hyyr	129	3	8,4	8,4	CD
cord-006860-a3b8hyyr	129	4	gM	gM	NNP
cord-006860-a3b8hyyr	129	5	resp	resp	NNP
cord-006860-a3b8hyyr	129	6	~	~	NNP
cord-006860-a3b8hyyr	129	7	tively	tively	NNP
cord-006860-a3b8hyyr	129	8	)	)	-RRB-
cord-006860-a3b8hyyr	130	1	,	,	,
cord-006860-a3b8hyyr	130	2	hirnlog	hirnlog	NNP
cord-006860-a3b8hyyr	130	3	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	130	4	APC	APC	NNP
cord-006860-a3b8hyyr	130	5	weakly	weakly	RB
cord-006860-a3b8hyyr	130	6	(	(	-LRB-
cord-006860-a3b8hyyr	130	7	60	60	CD
cord-006860-a3b8hyyr	130	8	p2¢I	p2¢i	CD
cord-006860-a3b8hyyr	130	9	produced	produce	VBN
cord-006860-a3b8hyyr	130	10	only	only	RB
cord-006860-a3b8hyyr	130	11	25	25	CD
cord-006860-a3b8hyyr	130	12	%	%	NN
cord-006860-a3b8hyyr	130	13	inhibition	inhibition	NN
cord-006860-a3b8hyyr	130	14	)	)	-RRB-
cord-006860-a3b8hyyr	130	15	,	,	,
cord-006860-a3b8hyyr	130	16	while	while	IN
cord-006860-a3b8hyyr	130	17	argatroban	argatroban	NNP
cord-006860-a3b8hyyr	130	18	and	and	CC
cord-006860-a3b8hyyr	130	19	~	~	NFP
cord-006860-a3b8hyyr	130	20	have	have	VB
cord-006860-a3b8hyyr	130	21	no	no	DT
cord-006860-a3b8hyyr	130	22	anti	anti	JJ
cord-006860-a3b8hyyr	130	23	-	-	JJ
cord-006860-a3b8hyyr	130	24	APC	APC	NNP
cord-006860-a3b8hyyr	130	25	activities	activity	NNS
cord-006860-a3b8hyyr	130	26	,	,	,
cord-006860-a3b8hyyr	130	27	While	while	IN
cord-006860-a3b8hyyr	130	28	hirulog	hirulog	NNP
cord-006860-a3b8hyyr	130	29	,	,	,
cord-006860-a3b8hyyr	130	30	hirudin	hirudin	NN
cord-006860-a3b8hyyr	130	31	and	and	CC
cord-006860-a3b8hyyr	130	32	argatroban	argatroban	NNP
cord-006860-a3b8hyyr	130	33	produced	produce	VBD
cord-006860-a3b8hyyr	130	34	no	no	DT
cord-006860-a3b8hyyr	130	35	direct	direct	JJ
cord-006860-a3b8hyyr	130	36	enti	enti	NNP
cord-006860-a3b8hyyr	130	37	-	-	HYPH
cord-006860-a3b8hyyr	130	38	APC	APC	NNP
cord-006860-a3b8hyyr	130	39	activities	activity	NNS
cord-006860-a3b8hyyr	130	40	,	,	,
cord-006860-a3b8hyyr	130	41	it	-PRON-	PRP
cord-006860-a3b8hyyr	130	42	is	be	VBZ
cord-006860-a3b8hyyr	130	43	conceivable	conceivable	JJ
cord-006860-a3b8hyyr	130	44	that	that	IN
cord-006860-a3b8hyyr	130	45	they	-PRON-	PRP
cord-006860-a3b8hyyr	130	46	may	may	MD
cord-006860-a3b8hyyr	130	47	inhibit	inhibit	VB
cord-006860-a3b8hyyr	130	48	thrombomodnlin	thrombomodnlin	NN
cord-006860-a3b8hyyr	130	49	-	-	HYPH
cord-006860-a3b8hyyr	130	50	bound	bind	VBN
cord-006860-a3b8hyyr	130	51	thrombin	thrombin	NN
cord-006860-a3b8hyyr	130	52	and	and	CC
cord-006860-a3b8hyyr	130	53	thus	thus	RB
cord-006860-a3b8hyyr	130	54	prevent	prevent	VB
cord-006860-a3b8hyyr	130	55	activation	activation	NN
cord-006860-a3b8hyyr	130	56	of	of	IN
cord-006860-a3b8hyyr	130	57	protein	protein	NN
cord-006860-a3b8hyyr	130	58	C	C	NNP
cord-006860-a3b8hyyr	130	59	,	,	,
cord-006860-a3b8hyyr	130	60	resulting	result	VBG
cord-006860-a3b8hyyr	130	61	in	in	IN
cord-006860-a3b8hyyr	130	62	a	a	DT
cord-006860-a3b8hyyr	130	63	functional	functional	JJ
cord-006860-a3b8hyyr	130	64	APC	APC	NNP
cord-006860-a3b8hyyr	130	65	deficit	deficit	NN
cord-006860-a3b8hyyr	130	66	and	and	CC
cord-006860-a3b8hyyr	130	67	failure	failure	NN
cord-006860-a3b8hyyr	130	68	to	to	TO
cord-006860-a3b8hyyr	130	69	improve	improve	VB
cord-006860-a3b8hyyr	130	70	clinical	clinical	JJ
cord-006860-a3b8hyyr	130	71	outcomes	outcome	NNS
cord-006860-a3b8hyyr	130	72	despite	despite	IN
cord-006860-a3b8hyyr	130	73	higher	high	JJR
cord-006860-a3b8hyyr	130	74	dosage	dosage	NN
cord-006860-a3b8hyyr	130	75	.	.	.
cord-006860-a3b8hyyr	131	1	While	while	IN
cord-006860-a3b8hyyr	131	2	initially	initially	RB
cord-006860-a3b8hyyr	131	3	it	-PRON-	PRP
cord-006860-a3b8hyyr	131	4	was	be	VBD
cord-006860-a3b8hyyr	131	5	thought	think	VBN
cord-006860-a3b8hyyr	131	6	that	that	IN
cord-006860-a3b8hyyr	131	7	sole	sole	JJ
cord-006860-a3b8hyyr	131	8	targeting	targeting	NN
cord-006860-a3b8hyyr	131	9	of	of	IN
cord-006860-a3b8hyyr	131	10	thrombin	thrombin	NN
cord-006860-a3b8hyyr	131	11	will	will	MD
cord-006860-a3b8hyyr	131	12	provide	provide	VB
cord-006860-a3b8hyyr	131	13	monospacifin	monospacifin	JJ
cord-006860-a3b8hyyr	131	14	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	131	15	agents	agent	NNS
cord-006860-a3b8hyyr	131	16	devoid	devoid	JJ
cord-006860-a3b8hyyr	131	17	of	of	IN
cord-006860-a3b8hyyr	131	18	some	some	DT
cord-006860-a3b8hyyr	131	19	of	of	IN
cord-006860-a3b8hyyr	131	20	the	the	DT
cord-006860-a3b8hyyr	131	21	adverse	adverse	JJ
cord-006860-a3b8hyyr	131	22	effects	effect	NNS
cord-006860-a3b8hyyr	131	23	observed	observe	VBN
cord-006860-a3b8hyyr	131	24	with	with	IN
cord-006860-a3b8hyyr	131	25	heparin	heparin	NN
cord-006860-a3b8hyyr	131	26	,	,	,
cord-006860-a3b8hyyr	131	27	the	the	DT
cord-006860-a3b8hyyr	131	28	recent	recent	JJ
cord-006860-a3b8hyyr	131	29	clinical	clinical	JJ
cord-006860-a3b8hyyr	131	30	trials	trial	NNS
cord-006860-a3b8hyyr	131	31	clearly	clearly	RB
cord-006860-a3b8hyyr	131	32	suggest	suggest	VBP
cord-006860-a3b8hyyr	131	33	that	that	IN
cord-006860-a3b8hyyr	131	34	thrombin	thrombin	NN
cord-006860-a3b8hyyr	131	35	is	be	VBZ
cord-006860-a3b8hyyr	131	36	not	not	RB
cord-006860-a3b8hyyr	131	37	the	the	DT
cord-006860-a3b8hyyr	131	38	only	only	JJ
cord-006860-a3b8hyyr	131	39	determinant	determinant	NN
cord-006860-a3b8hyyr	131	40	of	of	IN
cord-006860-a3b8hyyr	131	41	thrombogenesis	thrombogenesis	NN
cord-006860-a3b8hyyr	131	42	.	.	.
cord-006860-a3b8hyyr	132	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	132	2	,	,	,
cord-006860-a3b8hyyr	132	3	potent	potent	JJ
cord-006860-a3b8hyyr	132	4	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	132	5	agents	agent	NNS
cord-006860-a3b8hyyr	132	6	such	such	JJ
cord-006860-a3b8hyyr	132	7	as	as	IN
cord-006860-a3b8hyyr	132	8	hirudin	hirudin	NN
cord-006860-a3b8hyyr	132	9	,	,	,
cord-006860-a3b8hyyr	132	10	hirulog	hirulog	NNP
cord-006860-a3b8hyyr	132	11	and	and	CC
cord-006860-a3b8hyyr	132	12	peptides	peptide	NNS
cord-006860-a3b8hyyr	132	13	,	,	,
cord-006860-a3b8hyyr	132	14	indirectly	indirectly	RB
cord-006860-a3b8hyyr	132	15	inhibit	inhibit	VBP
cord-006860-a3b8hyyr	132	16	the	the	DT
cord-006860-a3b8hyyr	132	17	generation	generation	NN
cord-006860-a3b8hyyr	132	18	of	of	IN
cord-006860-a3b8hyyr	132	19	APC	APC	NNP
cord-006860-a3b8hyyr	132	20	,	,	,
cord-006860-a3b8hyyr	132	21	by	by	IN
cord-006860-a3b8hyyr	132	22	compromising	compromise	VBG
cord-006860-a3b8hyyr	132	23	thrombomodulin	thrombomodulin	NN
cord-006860-a3b8hyyr	132	24	-	-	HYPH
cord-006860-a3b8hyyr	132	25	bound	bind	VBN
cord-006860-a3b8hyyr	132	26	thrornhin	thrornhin	NN
cord-006860-a3b8hyyr	132	27	and	and	CC
cord-006860-a3b8hyyr	132	28	such	such	JJ
cord-006860-a3b8hyyr	132	29	agents	agent	NNS
cord-006860-a3b8hyyr	132	30	as	as	IN
cord-006860-a3b8hyyr	132	31	efegalran	efegalran	NNP
cord-006860-a3b8hyyr	132	32	and	and	CC
cord-006860-a3b8hyyr	132	33	DuP	DuP	VBD
cord-006860-a3b8hyyr	132	34	714	714	CD
cord-006860-a3b8hyyr	132	35	also	also	RB
cord-006860-a3b8hyyr	132	36	produce	produce	VB
cord-006860-a3b8hyyr	132	37	direct	direct	JJ
cord-006860-a3b8hyyr	132	38	APC	APC	NNP
cord-006860-a3b8hyyr	132	39	inhibition	inhibition	NN
cord-006860-a3b8hyyr	132	40	.	.	.
cord-006860-a3b8hyyr	133	1	Endogenous	endogenous	JJ
cord-006860-a3b8hyyr	133	2	inhibition	inhibition	NN
cord-006860-a3b8hyyr	133	3	of	of	IN
cord-006860-a3b8hyyr	133	4	formed	form	VBN
cord-006860-a3b8hyyr	133	5	APe	APe	NNS
cord-006860-a3b8hyyr	133	6	by	by	IN
cord-006860-a3b8hyyr	133	7	thrombin	thrombin	NN
cord-006860-a3b8hyyr	133	8	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	133	9	may	may	MD
cord-006860-a3b8hyyr	133	10	therefore	therefore	RB
cord-006860-a3b8hyyr	133	11	compromise	compromise	VB
cord-006860-a3b8hyyr	133	12	the	the	DT
cord-006860-a3b8hyyr	133	13	feedback	feedback	NN
cord-006860-a3b8hyyr	133	14	regulatory	regulatory	JJ
cord-006860-a3b8hyyr	133	15	funetiens	funetien	NNS
cord-006860-a3b8hyyr	133	16	of	of	IN
cord-006860-a3b8hyyr	133	17	APC	APC	NNP
cord-006860-a3b8hyyr	133	18	and	and	CC
cord-006860-a3b8hyyr	133	19	may	may	MD
cord-006860-a3b8hyyr	133	20	lead	lead	VB
cord-006860-a3b8hyyr	133	21	to	to	IN
cord-006860-a3b8hyyr	133	22	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	133	23	amplification	amplification	NN
cord-006860-a3b8hyyr	133	24	in	in	IN
cord-006860-a3b8hyyr	133	25	fully	fully	RB
cord-006860-a3b8hyyr	133	26	enticoagulated	enticoagulate	VBN
cord-006860-a3b8hyyr	133	27	patients	patient	NNS
cord-006860-a3b8hyyr	133	28	.	.	.
cord-006860-a3b8hyyr	134	1	These	these	DT
cord-006860-a3b8hyyr	134	2	studies	study	NNS
cord-006860-a3b8hyyr	134	3	warrant	warrant	VBP
cord-006860-a3b8hyyr	134	4	prcelinlcal	prcelinlcal	JJ
cord-006860-a3b8hyyr	134	5	assessment	assessment	NN
cord-006860-a3b8hyyr	134	6	of	of	IN
cord-006860-a3b8hyyr	134	7	thrombin	thrombin	NN
cord-006860-a3b8hyyr	134	8	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	134	9	to	to	TO
cord-006860-a3b8hyyr	134	10	evaluate	evaluate	VB
cord-006860-a3b8hyyr	134	11	their	-PRON-	PRP$
cord-006860-a3b8hyyr	134	12	relative	relative	JJ
cord-006860-a3b8hyyr	134	13	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	134	14	effects	effect	NNS
cord-006860-a3b8hyyr	134	15	on	on	IN
cord-006860-a3b8hyyr	134	16	APC	APC	NNP
cord-006860-a3b8hyyr	134	17	.	.	.
cord-006860-a3b8hyyr	135	1	Poor	poor	JJ
cord-006860-a3b8hyyr	135	2	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	135	3	response	response	NN
cord-006860-a3b8hyyr	135	4	to	to	IN
cord-006860-a3b8hyyr	135	5	activated	activate	VBN
cord-006860-a3b8hyyr	135	6	protein	protein	NN
cord-006860-a3b8hyyr	135	7	C	C	NNP
cord-006860-a3b8hyyr	135	8	(	(	-LRB-
cord-006860-a3b8hyyr	135	9	APC	APC	NNP
cord-006860-a3b8hyyr	135	10	resistance	resistance	NN
cord-006860-a3b8hyyr	135	11	)	)	-RRB-
cord-006860-a3b8hyyr	135	12	causes	cause	VBZ
cord-006860-a3b8hyyr	135	13	a	a	DT
cord-006860-a3b8hyyr	135	14	significant	significant	JJ
cord-006860-a3b8hyyr	135	15	portion	portion	NN
cord-006860-a3b8hyyr	135	16	of	of	IN
cord-006860-a3b8hyyr	135	17	deep	deep	JJ
cord-006860-a3b8hyyr	135	18	vein	vein	NN
cord-006860-a3b8hyyr	135	19	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	135	20	(	(	-LRB-
cord-006860-a3b8hyyr	135	21	DVT	DVT	NNP
cord-006860-a3b8hyyr	135	22	)	)	-RRB-
cord-006860-a3b8hyyr	135	23	whereas	whereas	IN
cord-006860-a3b8hyyr	135	24	its	-PRON-	PRP$
cord-006860-a3b8hyyr	135	25	association	association	NN
cord-006860-a3b8hyyr	135	26	with	with	IN
cord-006860-a3b8hyyr	135	27	coronary	coronary	JJ
cord-006860-a3b8hyyr	135	28	artery	artery	NN
cord-006860-a3b8hyyr	135	29	disease	disease	NN
cord-006860-a3b8hyyr	135	30	(	(	-LRB-
cord-006860-a3b8hyyr	135	31	CAD	CAD	NNP
cord-006860-a3b8hyyr	135	32	)	)	-RRB-
cord-006860-a3b8hyyr	135	33	and	and	CC
cord-006860-a3b8hyyr	135	34	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	135	35	infarction	infarction	NN
cord-006860-a3b8hyyr	135	36	(	(	-LRB-
cord-006860-a3b8hyyr	135	37	MD	MD	NNP
cord-006860-a3b8hyyr	135	38	is	be	VBZ
cord-006860-a3b8hyyr	135	39	still	still	RB
cord-006860-a3b8hyyr	135	40	controversial	controversial	JJ
cord-006860-a3b8hyyr	135	41	.	.	.
cord-006860-a3b8hyyr	136	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	136	2	,	,	,
cord-006860-a3b8hyyr	136	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	136	4	investigated	investigate	VBD
cord-006860-a3b8hyyr	136	5	346	346	CD
cord-006860-a3b8hyyr	136	6	recently	recently	RB
cord-006860-a3b8hyyr	136	7	hospitalised	hospitalise	VBN
cord-006860-a3b8hyyr	136	8	patients	patient	NNS
cord-006860-a3b8hyyr	136	9	suffering	suffer	VBG
cord-006860-a3b8hyyr	136	10	from	from	IN
cord-006860-a3b8hyyr	136	11	CAD	CAD	NNP
cord-006860-a3b8hyyr	136	12	with	with	IN
cord-006860-a3b8hyyr	136	13	or	or	CC
cord-006860-a3b8hyyr	136	14	without	without	IN
cord-006860-a3b8hyyr	136	15	previous	previous	JJ
cord-006860-a3b8hyyr	136	16	MI	MI	NNP
cord-006860-a3b8hyyr	136	17	.	.	.
cord-006860-a3b8hyyr	137	1	The	the	DT
cord-006860-a3b8hyyr	137	2	CAD	CAD	NNP
cord-006860-a3b8hyyr	137	3	was	be	VBD
cord-006860-a3b8hyyr	137	4	proven	prove	VBN
cord-006860-a3b8hyyr	137	5	by	by	IN
cord-006860-a3b8hyyr	137	6	coronary	coronary	JJ
cord-006860-a3b8hyyr	137	7	angiography	angiography	NN
cord-006860-a3b8hyyr	137	8	.	.	.
cord-006860-a3b8hyyr	138	1	APC	APC	NNP
cord-006860-a3b8hyyr	138	2	resistance	resistance	NN
cord-006860-a3b8hyyr	138	3	was	be	VBD
cord-006860-a3b8hyyr	138	4	analysed	analyse	VBN
cord-006860-a3b8hyyr	138	5	by	by	IN
cord-006860-a3b8hyyr	138	6	using	use	VBG
cord-006860-a3b8hyyr	138	7	the	the	DT
cord-006860-a3b8hyyr	138	8	aP'l	ap'l	JJ
cord-006860-a3b8hyyr	138	9	-	-	HYPH
cord-006860-a3b8hyyr	138	10	I'-based	i'-based	JJ
cord-006860-a3b8hyyr	138	11	assay	assay	NN
cord-006860-a3b8hyyr	138	12	COATEST	COATEST	NNP
cord-006860-a3b8hyyr	138	13	APC	APC	NNP
cord-006860-a3b8hyyr	138	14	Resistance	Resistance	NNP
cord-006860-a3b8hyyr	138	15	(	(	-LRB-
cord-006860-a3b8hyyr	138	16	Chromogenix	Chromogenix	NNP
cord-006860-a3b8hyyr	138	17	)	)	-RRB-
cord-006860-a3b8hyyr	138	18	.	.	.
cord-006860-a3b8hyyr	139	1	Eleven	eleven	CD
cord-006860-a3b8hyyr	139	2	patients	patient	NNS
cord-006860-a3b8hyyr	139	3	showed	show	VBD
cord-006860-a3b8hyyr	139	4	an	an	DT
cord-006860-a3b8hyyr	139	5	APC	APC	NNP
cord-006860-a3b8hyyr	139	6	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	139	7	index	index	NN
cord-006860-a3b8hyyr	139	8	below	below	IN
cord-006860-a3b8hyyr	139	9	2.0	2.0	CD
cord-006860-a3b8hyyr	139	10	viewed	view	VBD
cord-006860-a3b8hyyr	139	11	as	as	IN
cord-006860-a3b8hyyr	139	12	APC	APC	NNP
cord-006860-a3b8hyyr	139	13	resistance	resistance	NN
cord-006860-a3b8hyyr	139	14	.	.	.
cord-006860-a3b8hyyr	140	1	Using	use	VBG
cord-006860-a3b8hyyr	140	2	PCR	PCR	NNP
cord-006860-a3b8hyyr	140	3	technology	technology	NN
cord-006860-a3b8hyyr	140	4	,	,	,
cord-006860-a3b8hyyr	140	5	the	the	DT
cord-006860-a3b8hyyr	140	6	factor	factor	NN
cord-006860-a3b8hyyr	140	7	V	v	NN
cord-006860-a3b8hyyr	140	8	mutation	mutation	NN
cord-006860-a3b8hyyr	140	9	causing	cause	VBG
cord-006860-a3b8hyyr	140	10	APC	APC	NNP
cord-006860-a3b8hyyr	140	11	resistance	resistance	NN
cord-006860-a3b8hyyr	140	12	11691	11691	CD
cord-006860-a3b8hyyr	140	13	G	g	NN
cord-006860-a3b8hyyr	140	14	"	"	''
cord-006860-a3b8hyyr	140	15	-	-	,
cord-006860-a3b8hyyr	140	16	)	)	-RRB-
cord-006860-a3b8hyyr	140	17	A	a	NN
cord-006860-a3b8hyyr	140	18	)	)	-RRB-
cord-006860-a3b8hyyr	140	19	has	have	VBZ
cord-006860-a3b8hyyr	140	20	been	be	VBN
cord-006860-a3b8hyyr	140	21	shown	show	VBN
cord-006860-a3b8hyyr	140	22	in	in	IN
cord-006860-a3b8hyyr	140	23	nine	nine	CD
cord-006860-a3b8hyyr	140	24	of	of	IN
cord-006860-a3b8hyyr	140	25	these	these	DT
cord-006860-a3b8hyyr	140	26	eleven	eleven	CD
cord-006860-a3b8hyyr	140	27	patients	patient	NNS
cord-006860-a3b8hyyr	140	28	.	.	.
cord-006860-a3b8hyyr	141	1	This	this	DT
cord-006860-a3b8hyyr	141	2	represents	represent	VBZ
cord-006860-a3b8hyyr	141	3	2.6	2.6	CD
cord-006860-a3b8hyyr	141	4	%	%	NN
cord-006860-a3b8hyyr	141	5	(	(	-LRB-
cord-006860-a3b8hyyr	141	6	9/346	9/346	CD
cord-006860-a3b8hyyr	141	7	)	)	-RRB-
cord-006860-a3b8hyyr	141	8	,	,	,
cord-006860-a3b8hyyr	141	9	compared	compare	VBN
cord-006860-a3b8hyyr	141	10	to	to	IN
cord-006860-a3b8hyyr	141	11	8,5	8,5	CD
cord-006860-a3b8hyyr	141	12	%	%	NN
cord-006860-a3b8hyyr	141	13	found	find	VBN
cord-006860-a3b8hyyr	141	14	in	in	IN
cord-006860-a3b8hyyr	141	15	healthy	healthy	JJ
cord-006860-a3b8hyyr	141	16	blood	blood	NN
cord-006860-a3b8hyyr	141	17	donors	donor	NNS
cord-006860-a3b8hyyr	141	18	(	(	-LRB-
cord-006860-a3b8hyyr	141	19	8/94	8/94	CD
cord-006860-a3b8hyyr	141	20	)	)	-RRB-
cord-006860-a3b8hyyr	141	21	.	.	.
cord-006860-a3b8hyyr	142	1	One	one	CD
cord-006860-a3b8hyyr	142	2	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	142	3	carrier	carrier	NN
cord-006860-a3b8hyyr	142	4	(	(	-LRB-
cord-006860-a3b8hyyr	142	5	male	male	NN
cord-006860-a3b8hyyr	142	6	,	,	,
cord-006860-a3b8hyyr	142	7	age	age	NN
cord-006860-a3b8hyyr	142	8	76	76	CD
cord-006860-a3b8hyyr	142	9	)	)	-RRB-
cord-006860-a3b8hyyr	142	10	was	be	VBD
cord-006860-a3b8hyyr	142	11	identified	identify	VBN
cord-006860-a3b8hyyr	142	12	(	(	-LRB-
cord-006860-a3b8hyyr	142	13	APC	APC	NNP
cord-006860-a3b8hyyr	142	14	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	142	15	index	index	NN
cord-006860-a3b8hyyr	142	16	1.4	1.4	CD
cord-006860-a3b8hyyr	142	17	)	)	-RRB-
cord-006860-a3b8hyyr	142	18	who	who	WP
cord-006860-a3b8hyyr	142	19	suffered	suffer	VBD
cord-006860-a3b8hyyr	142	20	from	from	IN
cord-006860-a3b8hyyr	142	21	DVT	DVT	NNP
cord-006860-a3b8hyyr	142	22	at	at	IN
cord-006860-a3b8hyyr	142	23	age	age	NN
cord-006860-a3b8hyyr	142	24	59	59	CD
cord-006860-a3b8hyyr	142	25	.	.	.
cord-006860-a3b8hyyr	143	1	Recent	recent	JJ
cord-006860-a3b8hyyr	143	2	angiography	angiography	NN
cord-006860-a3b8hyyr	143	3	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	143	4	diffuse	diffuse	JJ
cord-006860-a3b8hyyr	143	5	CAD	CAD	NNP
cord-006860-a3b8hyyr	143	6	,	,	,
cord-006860-a3b8hyyr	143	7	No	no	DT
cord-006860-a3b8hyyr	143	8	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	143	9	events	event	NNS
cord-006860-a3b8hyyr	143	10	were	be	VBD
cord-006860-a3b8hyyr	143	11	reported	report	VBN
cord-006860-a3b8hyyr	143	12	in	in	IN
cord-006860-a3b8hyyr	143	13	his	-PRON-	PRP$
cord-006860-a3b8hyyr	143	14	family	family	NN
cord-006860-a3b8hyyr	143	15	.	.	.
cord-006860-a3b8hyyr	144	1	In	in	IN
cord-006860-a3b8hyyr	144	2	contrast	contrast	NN
cord-006860-a3b8hyyr	144	3	,	,	,
cord-006860-a3b8hyyr	144	4	multiple	multiple	JJ
cord-006860-a3b8hyyr	144	5	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	144	6	manifestations	manifestation	NNS
cord-006860-a3b8hyyr	144	7	(	(	-LRB-
cord-006860-a3b8hyyr	144	8	DVT	DVT	NNP
cord-006860-a3b8hyyr	144	9	,	,	,
cord-006860-a3b8hyyr	144	10	MI	MI	NNP
cord-006860-a3b8hyyr	144	11	,	,	,
cord-006860-a3b8hyyr	144	12	stroke	stroke	NN
cord-006860-a3b8hyyr	144	13	)	)	-RRB-
cord-006860-a3b8hyyr	144	14	occurred	occur	VBD
cord-006860-a3b8hyyr	144	15	in	in	IN
cord-006860-a3b8hyyr	144	16	the	the	DT
cord-006860-a3b8hyyr	144	17	relatives	relative	NNS
cord-006860-a3b8hyyr	144	18	of	of	IN
cord-006860-a3b8hyyr	144	19	four	four	CD
cord-006860-a3b8hyyr	144	20	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	144	21	patients	patient	NNS
cord-006860-a3b8hyyr	144	22	.	.	.
cord-006860-a3b8hyyr	145	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	145	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	145	3	that	that	IN
cord-006860-a3b8hyyr	145	4	the	the	DT
cord-006860-a3b8hyyr	145	5	prevalence	prevalence	NN
cord-006860-a3b8hyyr	145	6	of	of	IN
cord-006860-a3b8hyyr	145	7	APC	APC	NNP
cord-006860-a3b8hyyr	145	8	resistance	resistance	NN
cord-006860-a3b8hyyr	145	9	is	be	VBZ
cord-006860-a3b8hyyr	145	10	rather	rather	RB
cord-006860-a3b8hyyr	145	11	low	low	JJ
cord-006860-a3b8hyyr	145	12	in	in	IN
cord-006860-a3b8hyyr	145	13	patients	patient	NNS
cord-006860-a3b8hyyr	145	14	with	with	IN
cord-006860-a3b8hyyr	145	15	CAD	CAD	NNP
cord-006860-a3b8hyyr	145	16	.	.	.
cord-006860-a3b8hyyr	146	1	Nevertheless	nevertheless	RB
cord-006860-a3b8hyyr	146	2	,	,	,
cord-006860-a3b8hyyr	146	3	the	the	DT
cord-006860-a3b8hyyr	146	4	natural	natural	JJ
cord-006860-a3b8hyyr	146	5	history	history	NN
cord-006860-a3b8hyyr	146	6	of	of	IN
cord-006860-a3b8hyyr	146	7	coronary	coronary	JJ
cord-006860-a3b8hyyr	146	8	manifestation	manifestation	NN
cord-006860-a3b8hyyr	146	9	of	of	IN
cord-006860-a3b8hyyr	146	10	APC	APC	NNP
cord-006860-a3b8hyyr	146	11	resistance	resistance	NN
cord-006860-a3b8hyyr	146	12	seems	seem	VBZ
cord-006860-a3b8hyyr	146	13	to	to	TO
cord-006860-a3b8hyyr	146	14	vary	vary	VB
cord-006860-a3b8hyyr	146	15	,	,	,
cord-006860-a3b8hyyr	146	16	probably	probably	RB
cord-006860-a3b8hyyr	146	17	depending	depend	VBG
cord-006860-a3b8hyyr	146	18	on	on	IN
cord-006860-a3b8hyyr	146	19	the	the	DT
cord-006860-a3b8hyyr	146	20	presence	presence	NN
cord-006860-a3b8hyyr	146	21	and	and	CC
cord-006860-a3b8hyyr	146	22	severity	severity	NN
cord-006860-a3b8hyyr	146	23	of	of	IN
cord-006860-a3b8hyyr	146	24	cardiovascular	cardiovascular	JJ
cord-006860-a3b8hyyr	146	25	risk	risk	NN
cord-006860-a3b8hyyr	146	26	factors	factor	NNS
cord-006860-a3b8hyyr	146	27	.	.	.
cord-006860-a3b8hyyr	147	1	Resitanee	Resitanee	NNP
cord-006860-a3b8hyyr	147	2	to	to	IN
cord-006860-a3b8hyyr	147	3	activated	activate	VBN
cord-006860-a3b8hyyr	147	4	protein	protein	NN
cord-006860-a3b8hyyr	147	5	C	C	NNP
cord-006860-a3b8hyyr	147	6	(	(	-LRB-
cord-006860-a3b8hyyr	147	7	APC	APC	NNP
cord-006860-a3b8hyyr	147	8	resistance	resistance	NN
cord-006860-a3b8hyyr	147	9	)	)	-RRB-
cord-006860-a3b8hyyr	147	10	is	be	VBZ
cord-006860-a3b8hyyr	147	11	the	the	DT
cord-006860-a3b8hyyr	147	12	most	most	RBS
cord-006860-a3b8hyyr	147	13	cormnon	cormnon	JJ
cord-006860-a3b8hyyr	147	14	hereditary	hereditary	JJ
cord-006860-a3b8hyyr	147	15	cause	cause	NN
cord-006860-a3b8hyyr	147	16	of	of	IN
cord-006860-a3b8hyyr	147	17	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	147	18	and	and	CC
cord-006860-a3b8hyyr	147	19	significantly	significantly	RB
cord-006860-a3b8hyyr	147	20	linked	link	VBN
cord-006860-a3b8hyyr	147	21	to	to	IN
cord-006860-a3b8hyyr	147	22	factor	factor	NN
cord-006860-a3b8hyyr	147	23	V	V	NNP
cord-006860-a3b8hyyr	147	24	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	147	25	PCR	PCR	NNP
cord-006860-a3b8hyyr	147	26	based	base	VBN
cord-006860-a3b8hyyr	147	27	methods	method	NNS
cord-006860-a3b8hyyr	147	28	are	be	VBP
cord-006860-a3b8hyyr	147	29	used	use	VBN
cord-006860-a3b8hyyr	147	30	to	to	TO
cord-006860-a3b8hyyr	147	31	identify	identify	VB
cord-006860-a3b8hyyr	147	32	the	the	DT
cord-006860-a3b8hyyr	147	33	crucial	crucial	JJ
cord-006860-a3b8hyyr	147	34	point	point	NN
cord-006860-a3b8hyyr	147	35	mutation	mutation	NN
cord-006860-a3b8hyyr	147	36	in	in	IN
cord-006860-a3b8hyyr	147	37	the	the	DT
cord-006860-a3b8hyyr	147	38	factor	factor	NN
cord-006860-a3b8hyyr	147	39	V	V	NNP
cord-006860-a3b8hyyr	147	40	g(me	g(me	NNP
cord-006860-a3b8hyyr	147	41	.	.	.
cord-006860-a3b8hyyr	148	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	148	2	designed	design	VBD
cord-006860-a3b8hyyr	148	3	primers	primer	NNS
cord-006860-a3b8hyyr	148	4	in	in	IN
cord-006860-a3b8hyyr	148	5	order	order	NN
cord-006860-a3b8hyyr	148	6	to	to	TO
cord-006860-a3b8hyyr	148	7	identify	identify	VB
cord-006860-a3b8hyyr	148	8	factor	factor	NN
cord-006860-a3b8hyyr	148	9	V	V	NNP
cord-006860-a3b8hyyr	148	10	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	148	11	by	by	IN
cord-006860-a3b8hyyr	148	12	allele	allele	NN
cord-006860-a3b8hyyr	148	13	-	-	HYPH
cord-006860-a3b8hyyr	148	14	specific	specific	JJ
cord-006860-a3b8hyyr	148	15	PCR	PCR	NNP
cord-006860-a3b8hyyr	148	16	amplification	amplification	NN
cord-006860-a3b8hyyr	148	17	.	.	.
cord-006860-a3b8hyyr	149	1	Amplification	amplification	NN
cord-006860-a3b8hyyr	149	2	specificity	specificity	NN
cord-006860-a3b8hyyr	149	3	for	for	IN
cord-006860-a3b8hyyr	149	4	factor	factor	NN
cord-006860-a3b8hyyr	150	1	V	V	NNP
cord-006860-a3b8hyyr	150	2	was	be	VBD
cord-006860-a3b8hyyr	150	3	ensured	ensure	VBN
cord-006860-a3b8hyyr	150	4	by	by	IN
cord-006860-a3b8hyyr	150	5	the	the	DT
cord-006860-a3b8hyyr	150	6	3'primer	3'primer	CD
cord-006860-a3b8hyyr	150	7	FV1001	FV1001	NNP
cord-006860-a3b8hyyr	150	8	,	,	,
cord-006860-a3b8hyyr	150	9	located	locate	VBN
cord-006860-a3b8hyyr	150	10	at	at	IN
cord-006860-a3b8hyyr	150	11	the	the	DT
cord-006860-a3b8hyyr	150	12	introng	introng	NNP
cord-006860-a3b8hyyr	150	13	/	/	SYM
cord-006860-a3b8hyyr	150	14	intronl0	intronl0	NN
cord-006860-a3b8hyyr	150	15	border	border	NN
cord-006860-a3b8hyyr	150	16	of	of	IN
cord-006860-a3b8hyyr	150	17	the	the	DT
cord-006860-a3b8hyyr	150	18	g	g	NN
cord-006860-a3b8hyyr	150	19	~	~	NFP
cord-006860-a3b8hyyr	150	20	ae	ae	NNP
cord-006860-a3b8hyyr	150	21	.	.	.
cord-006860-a3b8hyyr	151	1	One	one	CD
cord-006860-a3b8hyyr	151	2	sense	sense	NN
cord-006860-a3b8hyyr	151	3	and	and	CC
cord-006860-a3b8hyyr	151	4	two	two	CD
cord-006860-a3b8hyyr	151	5	antisense	antisense	NN
cord-006860-a3b8hyyr	151	6	primers	primer	NNS
cord-006860-a3b8hyyr	151	7	were	be	VBD
cord-006860-a3b8hyyr	151	8	used	use	VBN
cord-006860-a3b8hyyr	151	9	in	in	IN
cord-006860-a3b8hyyr	151	10	~vo	~vo	NNP
cord-006860-a3b8hyyr	152	1	separate	separate	JJ
cord-006860-a3b8hyyr	152	2	primer	primer	NN
cord-006860-a3b8hyyr	152	3	mixes	mix	NNS
cord-006860-a3b8hyyr	152	4	specific	specific	JJ
cord-006860-a3b8hyyr	152	5	for	for	IN
cord-006860-a3b8hyyr	152	6	factor	factor	NN
cord-006860-a3b8hyyr	153	1	V	V	NNP
cord-006860-a3b8hyyr	153	2	ArtS06	ArtS06	NNP
cord-006860-a3b8hyyr	153	3	(	(	-LRB-
cord-006860-a3b8hyyr	153	4	wildtypo	wildtypo	NNP
cord-006860-a3b8hyyr	153	5	)	)	-RRB-
cord-006860-a3b8hyyr	153	6	or	or	CC
cord-006860-a3b8hyyr	153	7	factor	factor	NN
cord-006860-a3b8hyyr	153	8	V	V	NNP
cord-006860-a3b8hyyr	153	9	Otn506	otn506	CD
cord-006860-a3b8hyyr	153	10	(	(	-LRB-
cord-006860-a3b8hyyr	153	11	factor	factor	NN
cord-006860-a3b8hyyr	153	12	V	V	NNP
cord-006860-a3b8hyyr	153	13	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	153	14	)	)	-RRB-
cord-006860-a3b8hyyr	154	1	yielding	yield	VBG
cord-006860-a3b8hyyr	154	2	235bp	235bp	NNP
cord-006860-a3b8hyyr	154	3	products	product	NNS
cord-006860-a3b8hyyr	154	4	each	each	DT
cord-006860-a3b8hyyr	154	5	.	.	.
cord-006860-a3b8hyyr	155	1	In	in	IN
cord-006860-a3b8hyyr	155	2	each	each	DT
cord-006860-a3b8hyyr	155	3	PCR	PCR	NNP
cord-006860-a3b8hyyr	155	4	reaction	reaction	NN
cord-006860-a3b8hyyr	155	5	a	a	DT
cord-006860-a3b8hyyr	155	6	pair	pair	NN
cord-006860-a3b8hyyr	155	7	of	of	IN
cord-006860-a3b8hyyr	155	8	primers	primer	NNS
cord-006860-a3b8hyyr	155	9	amplifying	amplify	VBG
cord-006860-a3b8hyyr	155	10	a	a	DT
cord-006860-a3b8hyyr	155	11	fragment	fragment	NN
cord-006860-a3b8hyyr	155	12	of	of	IN
cord-006860-a3b8hyyr	155	13	the	the	DT
cord-006860-a3b8hyyr	155	14	human	human	JJ
cord-006860-a3b8hyyr	155	15	growth	growth	NN
cord-006860-a3b8hyyr	155	16	hormone	hormone	NN
cord-006860-a3b8hyyr	155	17	gene	gene	NN
cord-006860-a3b8hyyr	155	18	was	be	VBD
cord-006860-a3b8hyyr	155	19	included	include	VBN
cord-006860-a3b8hyyr	155	20	,	,	,
cord-006860-a3b8hyyr	155	21	fimctioning	fimctione	VBG
cord-006860-a3b8hyyr	155	22	as	as	IN
cord-006860-a3b8hyyr	155	23	an	an	DT
cord-006860-a3b8hyyr	155	24	internal	internal	JJ
cord-006860-a3b8hyyr	155	25	positive	positive	JJ
cord-006860-a3b8hyyr	155	26	amplification	amplification	NN
cord-006860-a3b8hyyr	155	27	control	control	NN
cord-006860-a3b8hyyr	155	28	(	(	-LRB-
cord-006860-a3b8hyyr	155	29	429bp	429bp	NNP
cord-006860-a3b8hyyr	155	30	PCRfragment	PCRfragment	NNP
cord-006860-a3b8hyyr	155	31	)	)	-RRB-
cord-006860-a3b8hyyr	155	32	.	.	.
cord-006860-a3b8hyyr	156	1	After	after	IN
cord-006860-a3b8hyyr	156	2	an	an	DT
cord-006860-a3b8hyyr	156	3	initial	initial	JJ
cord-006860-a3b8hyyr	156	4	denaturation	denaturation	NN
cord-006860-a3b8hyyr	156	5	step	step	NN
cord-006860-a3b8hyyr	156	6	10/.tl	10/.tl	CD
cord-006860-a3b8hyyr	156	7	samples	sample	NNS
cord-006860-a3b8hyyr	156	8	(	(	-LRB-
cord-006860-a3b8hyyr	156	9	100rig	100rig	CD
cord-006860-a3b8hyyr	156	10	genomic	genomic	JJ
cord-006860-a3b8hyyr	156	11	DNA	dna	NN
cord-006860-a3b8hyyr	156	12	)	)	-RRB-
cord-006860-a3b8hyyr	156	13	were	be	VBD
cord-006860-a3b8hyyr	156	14	subjected	subject	VBN
cord-006860-a3b8hyyr	156	15	to	to	IN
cord-006860-a3b8hyyr	156	16	10	10	CD
cord-006860-a3b8hyyr	156	17	two	two	CD
cord-006860-a3b8hyyr	156	18	-	-	HYPH
cord-006860-a3b8hyyr	156	19	temperature	temperature	NN
cord-006860-a3b8hyyr	156	20	cycles	cycle	NNS
cord-006860-a3b8hyyr	156	21	foUowed	fouowe	VBN
cord-006860-a3b8hyyr	156	22	by	by	IN
cord-006860-a3b8hyyr	156	23	20	20	CD
cord-006860-a3b8hyyr	156	24	threetemperature	threetemperature	NN
cord-006860-a3b8hyyr	156	25	cycles	cycle	NNS
cord-006860-a3b8hyyr	156	26	.	.	.
cord-006860-a3b8hyyr	157	1	For	for	IN
cord-006860-a3b8hyyr	157	2	visualisation	visualisation	NN
cord-006860-a3b8hyyr	157	3	8p3	8p3	CD
cord-006860-a3b8hyyr	157	4	of	of	IN
cord-006860-a3b8hyyr	157	5	the	the	DT
cord-006860-a3b8hyyr	157	6	amplification	amplification	NN
cord-006860-a3b8hyyr	157	7	product	product	NN
cord-006860-a3b8hyyr	157	8	were	be	VBD
cord-006860-a3b8hyyr	157	9	run	run	VBN
cord-006860-a3b8hyyr	157	10	on	on	IN
cord-006860-a3b8hyyr	157	11	a	a	DT
cord-006860-a3b8hyyr	157	12	2	2	CD
cord-006860-a3b8hyyr	157	13	%	%	NN
cord-006860-a3b8hyyr	157	14	agarose	agarose	NN
cord-006860-a3b8hyyr	157	15	gel	gel	NN
cord-006860-a3b8hyyr	157	16	presmined	presmine	VBN
cord-006860-a3b8hyyr	157	17	with	with	IN
cord-006860-a3b8hyyr	157	18	ethidittm	ethidittm	JJ
cord-006860-a3b8hyyr	157	19	bromide	bromide	NN
cord-006860-a3b8hyyr	157	20	.	.	.
cord-006860-a3b8hyyr	158	1	The	the	DT
cord-006860-a3b8hyyr	158	2	presence	presence	NN
cord-006860-a3b8hyyr	158	3	or	or	CC
cord-006860-a3b8hyyr	158	4	absence	absence	NN
cord-006860-a3b8hyyr	158	5	of	of	IN
cord-006860-a3b8hyyr	158	6	specific	specific	JJ
cord-006860-a3b8hyyr	158	7	PCR	PCR	NNP
cord-006860-a3b8hyyr	158	8	amplification	amplification	NN
cord-006860-a3b8hyyr	158	9	allowed	allow	VBD
cord-006860-a3b8hyyr	158	10	defiu	defiu	NNP
cord-006860-a3b8hyyr	158	11	/	/	SYM
cord-006860-a3b8hyyr	158	12	te	te	NNP
cord-006860-a3b8hyyr	158	13	allele	allele	NN
cord-006860-a3b8hyyr	158	14	assignment	assignment	NN
cord-006860-a3b8hyyr	158	15	without	without	IN
cord-006860-a3b8hyyr	158	16	the	the	DT
cord-006860-a3b8hyyr	158	17	need	need	NN
cord-006860-a3b8hyyr	158	18	for	for	IN
cord-006860-a3b8hyyr	158	19	any	any	DT
cord-006860-a3b8hyyr	158	20	postamplifieation	postamplifieation	NN
cord-006860-a3b8hyyr	158	21	specificity	specificity	NN
cord-006860-a3b8hyyr	158	22	step	step	NN
cord-006860-a3b8hyyr	158	23	.	.	.
cord-006860-a3b8hyyr	159	1	The	the	DT
cord-006860-a3b8hyyr	159	2	in	in	IN
cord-006860-a3b8hyyr	159	3	~	~	NFP
cord-006860-a3b8hyyr	159	4	ernal	ernal	JJ
cord-006860-a3b8hyyr	159	5	positive	positive	JJ
cord-006860-a3b8hyyr	159	6	control	control	NN
cord-006860-a3b8hyyr	159	7	primers	primer	NNS
cord-006860-a3b8hyyr	159	8	it	-PRON-	PRP
cord-006860-a3b8hyyr	160	1	~cate	~cate	NFP
cord-006860-a3b8hyyr	160	2	a	a	DT
cord-006860-a3b8hyyr	160	3	sucessf	sucessf	NN
cord-006860-a3b8hyyr	160	4	-	-	HYPH
cord-006860-a3b8hyyr	160	5	u	u	NNP
cord-006860-a3b8hyyr	160	6	/	/	SYM
cord-006860-a3b8hyyr	160	7	PCR	PCR	NNP
cord-006860-a3b8hyyr	160	8	amplification	amplification	NN
cord-006860-a3b8hyyr	160	9	,	,	,
cord-006860-a3b8hyyr	160	10	allowing	allow	VBG
cord-006860-a3b8hyyr	160	11	the	the	DT
cord-006860-a3b8hyyr	160	12	assignment	assignment	NN
cord-006860-a3b8hyyr	160	13	of	of	IN
cord-006860-a3b8hyyr	160	14	homozygosity	homozygosity	NN
cord-006860-a3b8hyyr	160	15	.	.	.
cord-006860-a3b8hyyr	161	1	In	in	IN
cord-006860-a3b8hyyr	161	2	a	a	DT
cord-006860-a3b8hyyr	161	3	prospective	prospective	JJ
cord-006860-a3b8hyyr	161	4	study	study	NN
cord-006860-a3b8hyyr	161	5	126	126	CD
cord-006860-a3b8hyyr	161	6	p	p	NN
cord-006860-a3b8hyyr	161	7	~	~	NFP
cord-006860-a3b8hyyr	161	8	e.ients	e.ients	:
cord-006860-a3b8hyyr	161	9	with	with	IN
cord-006860-a3b8hyyr	161	10	tlaromboembolic	tlaromboembolic	NNP
cord-006860-a3b8hyyr	161	11	events	event	NNS
cord-006860-a3b8hyyr	161	12	were	be	VBD
cord-006860-a3b8hyyr	161	13	analysed	analyse	VBN
cord-006860-a3b8hyyr	161	14	using	use	VBG
cord-006860-a3b8hyyr	161	15	this	this	DT
cord-006860-a3b8hyyr	161	16	technique	technique	NN
cord-006860-a3b8hyyr	161	17	and	and	CC
cord-006860-a3b8hyyr	161	18	enmpared	enmpare	VBD
cord-006860-a3b8hyyr	161	19	with	with	IN
cord-006860-a3b8hyyr	161	20	PCR	PCR	NNP
cord-006860-a3b8hyyr	161	21	-RFLP	-RFLP	.
cord-006860-a3b8hyyr	162	1	according	accord	VBG
cord-006860-a3b8hyyr	162	2	to	to	IN
cord-006860-a3b8hyyr	162	3	Bertina	Bertina	NNP
cord-006860-a3b8hyyr	162	4	et	et	NNP
cord-006860-a3b8hyyr	162	5	al	al	NNP
cord-006860-a3b8hyyr	162	6	.	.	.
cord-006860-a3b8hyyr	163	1	The	the	DT
cord-006860-a3b8hyyr	163	2	concordance	concordance	NN
cord-006860-a3b8hyyr	163	3	between	between	IN
cord-006860-a3b8hyyr	163	4	these	these	DT
cord-006860-a3b8hyyr	163	5	techniques	technique	NNS
cord-006860-a3b8hyyr	163	6	was	be	VBD
cord-006860-a3b8hyyr	163	7	100	100	CD
cord-006860-a3b8hyyr	163	8	%	%	NN
cord-006860-a3b8hyyr	163	9	.	.	.
cord-006860-a3b8hyyr	164	1	In	in	IN
cord-006860-a3b8hyyr	164	2	27	27	CD
cord-006860-a3b8hyyr	164	3	patients	patient	NNS
cord-006860-a3b8hyyr	164	4	a	a	DT
cord-006860-a3b8hyyr	164	5	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	164	6	factor	factor	NN
cord-006860-a3b8hyyr	164	7	V	V	NNP
cord-006860-a3b8hyyr	164	8	OhaS06	OhaS06	NNP
cord-006860-a3b8hyyr	164	9	mutation	mutation	NN
cord-006860-a3b8hyyr	164	10	was	be	VBD
cord-006860-a3b8hyyr	164	11	detected	detect	VBN
cord-006860-a3b8hyyr	164	12	,	,	,
cord-006860-a3b8hyyr	164	13	whereas	whereas	IN
cord-006860-a3b8hyyr	164	14	one	one	CD
cord-006860-a3b8hyyr	164	15	pa6ent	pa6ent	NN
cord-006860-a3b8hyyr	164	16	with	with	IN
cord-006860-a3b8hyyr	164	17	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	164	18	thrombcembolism	thrombcembolism	NN
cord-006860-a3b8hyyr	164	19	was	be	VBD
cord-006860-a3b8hyyr	164	20	homoz	homoz	NNP
cord-006860-a3b8hyyr	164	21	-	-	HYPH
cord-006860-a3b8hyyr	164	22	ygous	ygous	NNP
cord-006860-a3b8hyyr	164	23	.	.	.
cord-006860-a3b8hyyr	165	1	No	no	DT
cord-006860-a3b8hyyr	165	2	faLse	false	JJ
cord-006860-a3b8hyyr	165	3	-	-	HYPH
cord-006860-a3b8hyyr	165	4	positive	positive	JJ
cord-006860-a3b8hyyr	165	5	or	or	CC
cord-006860-a3b8hyyr	165	6	false	false	JJ
cord-006860-a3b8hyyr	165	7	-	-	HYPH
cord-006860-a3b8hyyr	165	8	negative	negative	JJ
cord-006860-a3b8hyyr	165	9	results	result	NNS
cord-006860-a3b8hyyr	165	10	worn	wear	VBN
cord-006860-a3b8hyyr	165	11	observed	observe	VBN
cord-006860-a3b8hyyr	165	12	in	in	IN
cord-006860-a3b8hyyr	165	13	the	the	DT
cord-006860-a3b8hyyr	165	14	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	165	15	as	as	RB
cord-006860-a3b8hyyr	165	16	well	well	RB
cord-006860-a3b8hyyr	165	17	as	as	IN
cord-006860-a3b8hyyr	165	18	hcterozygous	hcterozygous	NNP
cord-006860-a3b8hyyr	165	19	samples	sample	NNS
cord-006860-a3b8hyyr	165	20	.	.	.
cord-006860-a3b8hyyr	166	1	In	in	IN
cord-006860-a3b8hyyr	166	2	addition	addition	NN
cord-006860-a3b8hyyr	166	3	in	in	IN
cord-006860-a3b8hyyr	166	4	15	15	CD
cord-006860-a3b8hyyr	166	5	samples	sample	NNS
cord-006860-a3b8hyyr	166	6	identified	identify	VBN
cord-006860-a3b8hyyr	166	7	to	to	TO
cord-006860-a3b8hyyr	166	8	carry	carry	VB
cord-006860-a3b8hyyr	166	9	the	the	DT
cord-006860-a3b8hyyr	166	10	point	point	NN
cord-006860-a3b8hyyr	166	11	mutation	mutation	NN
cord-006860-a3b8hyyr	166	12	by	by	IN
cord-006860-a3b8hyyr	166	13	al	al	NNP
cord-006860-a3b8hyyr	166	14	/	/	SYM
cord-006860-a3b8hyyr	166	15	ele	ele	NNP
cord-006860-a3b8hyyr	166	16	-	-	HYPH
cord-006860-a3b8hyyr	166	17	specifin	specifin	NNP
cord-006860-a3b8hyyr	166	18	PCR	PCR	NNP
cord-006860-a3b8hyyr	166	19	anxplification	anxplification	NN
cord-006860-a3b8hyyr	166	20	automatic	automatic	NN
cord-006860-a3b8hyyr	166	21	:	:	:
cord-006860-a3b8hyyr	166	22	~equencing	~equencing	NNP
cord-006860-a3b8hyyr	166	23	confirmed	confirm	VBD
cord-006860-a3b8hyyr	166	24	the	the	DT
cord-006860-a3b8hyyr	166	25	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	166	26	or	or	CC
cord-006860-a3b8hyyr	166	27	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	166	28	point	point	NN
cord-006860-a3b8hyyr	166	29	mutation	mutation	NN
cord-006860-a3b8hyyr	166	30	.	.	.
cord-006860-a3b8hyyr	167	1	Due	due	IN
cord-006860-a3b8hyyr	167	2	to	to	IN
cord-006860-a3b8hyyr	167	3	its	-PRON-	PRP$
cord-006860-a3b8hyyr	167	4	time	time	NN
cord-006860-a3b8hyyr	167	5	-	-	HYPH
cord-006860-a3b8hyyr	167	6	and	and	CC
cord-006860-a3b8hyyr	167	7	cost	cost	NN
cord-006860-a3b8hyyr	167	8	-	-	HYPH
cord-006860-a3b8hyyr	167	9	saving	save	VBG
cord-006860-a3b8hyyr	167	10	features	feature	NNS
cord-006860-a3b8hyyr	167	11	allele	allele	NN
cord-006860-a3b8hyyr	167	12	-	-	HYPH
cord-006860-a3b8hyyr	167	13	specific	specific	JJ
cord-006860-a3b8hyyr	167	14	amplification	amplification	NN
cord-006860-a3b8hyyr	167	15	should	should	MD
cord-006860-a3b8hyyr	167	16	be	be	VB
cord-006860-a3b8hyyr	167	17	considered	consider	VBN
cord-006860-a3b8hyyr	167	18	for	for	IN
cord-006860-a3b8hyyr	167	19	screening	screening	NN
cord-006860-a3b8hyyr	167	20	of	of	IN
cord-006860-a3b8hyyr	167	21	factor	factor	NN
cord-006860-a3b8hyyr	167	22	V	V	NNP
cord-006860-a3b8hyyr	167	23	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	167	24	.	.	.
cord-006860-a3b8hyyr	168	1	Background	background	NN
cord-006860-a3b8hyyr	168	2	:	:	:
cord-006860-a3b8hyyr	169	1	An	an	DT
cord-006860-a3b8hyyr	169	2	initial	initial	JJ
cord-006860-a3b8hyyr	169	3	intravenous	intravenous	JJ
cord-006860-a3b8hyyr	169	4	course	course	NN
cord-006860-a3b8hyyr	169	5	of	of	IN
cord-006860-a3b8hyyr	169	6	tmfractionated	tmfractionate	VBN
cord-006860-a3b8hyyr	169	7	heparin	heparin	NNP
cord-006860-a3b8hyyr	170	1	~ljasted	~ljaste	VBN
cord-006860-a3b8hyyr	170	2	on	on	IN
cord-006860-a3b8hyyr	170	3	the	the	DT
cord-006860-a3b8hyyr	170	4	basis	basis	NN
cord-006860-a3b8hyyr	170	5	of	of	IN
cord-006860-a3b8hyyr	170	6	the	the	DT
cord-006860-a3b8hyyr	170	7	activated	activate	VBN
cord-006860-a3b8hyyr	170	8	partial	partial	JJ
cord-006860-a3b8hyyr	170	9	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	170	10	time	time	NN
cord-006860-a3b8hyyr	170	11	is	be	VBZ
cord-006860-a3b8hyyr	170	12	the	the	DT
cord-006860-a3b8hyyr	170	13	currmt	currmt	NN
cord-006860-a3b8hyyr	170	14	standard	standard	JJ
cord-006860-a3b8hyyr	170	15	treatment	treatment	NN
cord-006860-a3b8hyyr	170	16	for	for	IN
cord-006860-a3b8hyyr	170	17	most	most	JJS
cord-006860-a3b8hyyr	170	18	patients	patient	NNS
cord-006860-a3b8hyyr	170	19	with	with	IN
cord-006860-a3b8hyyr	170	20	venous	venous	JJ
cord-006860-a3b8hyyr	170	21	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	170	22	.	.	.
cord-006860-a3b8hyyr	171	1	Low	low	JJ
cord-006860-a3b8hyyr	171	2	-	-	HYPH
cord-006860-a3b8hyyr	171	3	molecularweight	molecularweight	NN
cord-006860-a3b8hyyr	171	4	hqmrin	hqmrin	NNP
cord-006860-a3b8hyyr	171	5	pre~	pre~	CD
cord-006860-a3b8hyyr	172	1	a	a	LS
cord-006860-a3b8hyyr	172	2	~	~	CD
cord-006860-a3b8hyyr	172	3	tious	tious	NNP
cord-006860-a3b8hyyr	172	4	can	can	MD
cord-006860-a3b8hyyr	172	5	be	be	VB
cord-006860-a3b8hyyr	172	6	administered	administer	VBN
cord-006860-a3b8hyyr	172	7	subcutaneously	subcutaneously	RB
cord-006860-a3b8hyyr	172	8	,	,	,
cord-006860-a3b8hyyr	172	9	once	once	RB
cord-006860-a3b8hyyr	172	10	or	or	CC
cord-006860-a3b8hyyr	172	11	twice	twice	RB
cord-006860-a3b8hyyr	172	12	daily	daily	RB
cord-006860-a3b8hyyr	172	13	,	,	,
cord-006860-a3b8hyyr	172	14	without	without	IN
cord-006860-a3b8hyyr	172	15	laboratory	laboratory	NN
cord-006860-a3b8hyyr	172	16	monitoring	monitoring	NN
cord-006860-a3b8hyyr	172	17	.	.	.
cord-006860-a3b8hyyr	173	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	173	2	compared	compare	VBD
cord-006860-a3b8hyyr	173	3	the	the	DT
cord-006860-a3b8hyyr	173	4	relative	relative	JJ
cord-006860-a3b8hyyr	173	5	effic.~y	effic.~y	NN
cord-006860-a3b8hyyr	173	6	and	and	CC
cord-006860-a3b8hyyr	173	7	safety	safety	NN
cord-006860-a3b8hyyr	173	8	of	of	IN
cord-006860-a3b8hyyr	173	9	low	low	JJ
cord-006860-a3b8hyyr	173	10	-	-	HYPH
cord-006860-a3b8hyyr	173	11	molecular	molecular	JJ
cord-006860-a3b8hyyr	173	12	weight	weight	NN
cord-006860-a3b8hyyr	173	13	heparin	heparin	NN
cord-006860-a3b8hyyr	173	14	versus	versus	IN
cord-006860-a3b8hyyr	173	15	anfractionated	anfractionated	JJ
cord-006860-a3b8hyyr	173	16	heparin	heparin	NNP
cord-006860-a3b8hyyr	173	17	for	for	IN
cord-006860-a3b8hyyr	173	18	the	the	DT
cord-006860-a3b8hyyr	173	19	initial	initial	JJ
cord-006860-a3b8hyyr	173	20	treatment	treatment	NN
cord-006860-a3b8hyyr	173	21	of	of	IN
cord-006860-a3b8hyyr	173	22	deep	deep	JJ
cord-006860-a3b8hyyr	173	23	venous	venous	JJ
cord-006860-a3b8hyyr	173	24	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	173	25	.	.	.
cord-006860-a3b8hyyr	174	1	Methods	method	NNS
cord-006860-a3b8hyyr	174	2	:	:	:
cord-006860-a3b8hyyr	174	3	English	english	JJ
cord-006860-a3b8hyyr	174	4	-	-	HYPH
cord-006860-a3b8hyyr	174	5	language	language	NN
cord-006860-a3b8hyyr	174	6	reports	report	NNS
cord-006860-a3b8hyyr	174	7	of	of	IN
cord-006860-a3b8hyyr	174	8	randomized	randomized	JJ
cord-006860-a3b8hyyr	174	9	trials	trial	NNS
cord-006860-a3b8hyyr	174	10	vtta'e	vtta'e	,
cord-006860-a3b8hyyr	174	11	identified	identify	VBN
cord-006860-a3b8hyyr	174	12	th~	th~	NNP
cord-006860-a3b8hyyr	174	13	a	a	DT
cord-006860-a3b8hyyr	174	14	MEDLINE	MEDLINE	NNP
cord-006860-a3b8hyyr	174	15	search	search	NN
cord-006860-a3b8hyyr	174	16	(	(	-LRB-
cord-006860-a3b8hyyr	174	17	1984	1984	CD
cord-006860-a3b8hyyr	174	18	through	through	IN
cord-006860-a3b8hyyr	174	19	1995	1995	CD
cord-006860-a3b8hyyr	174	20	)	)	-RRB-
cord-006860-a3b8hyyr	174	21	and	and	CC
cord-006860-a3b8hyyr	174	22	a	a	DT
cord-006860-a3b8hyyr	174	23	complementary	complementary	JJ
cord-006860-a3b8hyyr	174	24	extensive	extensive	JJ
cord-006860-a3b8hyyr	174	25	manual	manual	JJ
cord-006860-a3b8hyyr	174	26	search	search	NN
cord-006860-a3b8hyyr	174	27	.	.	.
cord-006860-a3b8hyyr	175	1	Reasons	reason	NNS
cord-006860-a3b8hyyr	175	2	for	for	IN
cord-006860-a3b8hyyr	175	3	exclusion	exclusion	NN
cord-006860-a3b8hyyr	175	4	from	from	IN
cord-006860-a3b8hyyr	175	5	the	the	DT
cord-006860-a3b8hyyr	175	6	analysis	analysis	NN
cord-006860-a3b8hyyr	175	7	were	be	VBD
cord-006860-a3b8hyyr	175	8	no	no	DT
cord-006860-a3b8hyyr	175	9	hepada	hepada	NNP
cord-006860-a3b8hyyr	175	10	dosage	dosage	NN
cord-006860-a3b8hyyr	175	11	adjustments	adjustment	NNS
cord-006860-a3b8hyyr	175	12	,	,	,
cord-006860-a3b8hyyr	175	13	the	the	DT
cord-006860-a3b8hyyr	175	14	lack	lack	NN
cord-006860-a3b8hyyr	175	15	of	of	IN
cord-006860-a3b8hyyr	175	16	um	um	UH
cord-006860-a3b8hyyr	175	17	of	of	IN
cord-006860-a3b8hyyr	175	18	obj	obj	NN
cord-006860-a3b8hyyr	175	19	~	~	:
cord-006860-a3b8hyyr	175	20	tive	tive	JJ
cord-006860-a3b8hyyr	175	21	tests	test	NNS
cord-006860-a3b8hyyr	175	22	for	for	IN
cord-006860-a3b8hyyr	175	23	deep	deep	JJ
cord-006860-a3b8hyyr	175	24	venous	venous	JJ
cord-006860-a3b8hyyr	175	25	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	175	26	,	,	,
cord-006860-a3b8hyyr	175	27	dos	do	NNS
cord-006860-a3b8hyyr	175	28	~	~	NFP
cord-006860-a3b8hyyr	175	29	ranging	range	VBG
cord-006860-a3b8hyyr	175	30	studies	study	NNS
cord-006860-a3b8hyyr	175	31	that	that	WDT
cord-006860-a3b8hyyr	175	32	used	use	VBD
cord-006860-a3b8hyyr	175	33	higher	high	JJR
cord-006860-a3b8hyyr	175	34	doses	dose	NNS
cord-006860-a3b8hyyr	175	35	of	of	IN
cord-006860-a3b8hyyr	175	36	low	low	JJ
cord-006860-a3b8hyyr	175	37	-	-	HYPH
cord-006860-a3b8hyyr	175	38	molecularweight	molecularweight	NN
cord-006860-a3b8hyyr	175	39	heparin	heparin	NN
cord-006860-a3b8hyyr	175	40	than	than	IN
cord-006860-a3b8hyyr	175	41	are	be	VBP
cord-006860-a3b8hyyr	175	42	ctareatly	ctareatly	RB
cord-006860-a3b8hyyr	175	43	in	in	IN
cord-006860-a3b8hyyr	175	44	use	use	NN
cord-006860-a3b8hyyr	175	45	,	,	,
cord-006860-a3b8hyyr	175	46	and	and	CC
cord-006860-a3b8hyyr	175	47	the	the	DT
cord-006860-a3b8hyyr	175	48	failure	failure	NN
cord-006860-a3b8hyyr	175	49	to	to	TO
cord-006860-a3b8hyyr	175	50	provide	provide	VB
cord-006860-a3b8hyyr	175	51	blind	blind	JJ
cord-006860-a3b8hyyr	175	52	endpoint	endpoint	NN
cord-006860-a3b8hyyr	175	53	~sossmeat	~sossmeat	ADD
cord-006860-a3b8hyyr	175	54	.	.	.
cord-006860-a3b8hyyr	176	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	176	2	assessed	assess	VBD
cord-006860-a3b8hyyr	176	3	the	the	DT
cord-006860-a3b8hyyr	176	4	incidence	incidence	NN
cord-006860-a3b8hyyr	176	5	of	of	IN
cord-006860-a3b8hyyr	176	6	symptomatic	symptomatic	JJ
cord-006860-a3b8hyyr	176	7	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	176	8	vinous	vinous	JJ
cord-006860-a3b8hyyr	176	9	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	176	10	disease	disease	NN
cord-006860-a3b8hyyr	176	11	,	,	,
cord-006860-a3b8hyyr	176	12	the	the	DT
cord-006860-a3b8hyyr	176	13	incidence	incidence	NN
cord-006860-a3b8hyyr	176	14	of	of	IN
cord-006860-a3b8hyyr	176	15	clinically	clinically	RB
cord-006860-a3b8hyyr	176	16	ii	ii	NN
cord-006860-a3b8hyyr	176	17	~	~	NFP
cord-006860-a3b8hyyr	176	18	t	t	NN
cord-006860-a3b8hyyr	176	19	bleeding	bleeding	NN
cord-006860-a3b8hyyr	176	20	and	and	CC
cord-006860-a3b8hyyr	176	21	mortality	mortality	NN
cord-006860-a3b8hyyr	176	22	.	.	.
cord-006860-a3b8hyyr	177	1	Results	result	NNS
cord-006860-a3b8hyyr	177	2	:	:	:
cord-006860-a3b8hyyr	178	1	Twelve	twelve	CD
cord-006860-a3b8hyyr	178	2	of	of	IN
cord-006860-a3b8hyyr	178	3	the	the	DT
cord-006860-a3b8hyyr	178	4	21	21	CD
cord-006860-a3b8hyyr	178	5	identified	identify	VBN
cord-006860-a3b8hyyr	178	6	trials	trial	NNS
cord-006860-a3b8hyyr	178	7	satisfied	satisfy	VBD
cord-006860-a3b8hyyr	178	8	the	the	DT
cord-006860-a3b8hyyr	178	9	predetermined	predetermine	VBN
cord-006860-a3b8hyyr	178	10	criteria	criterion	NNS
cord-006860-a3b8hyyr	178	11	.	.	.
cord-006860-a3b8hyyr	179	1	The	the	DT
cord-006860-a3b8hyyr	179	2	relative	relative	JJ
cord-006860-a3b8hyyr	179	3	risk	risk	NN
cord-006860-a3b8hyyr	179	4	reductions	reduction	NNS
cord-006860-a3b8hyyr	179	5	for	for	IN
cord-006860-a3b8hyyr	179	6	symptomatic	symptomatic	JJ
cord-006860-a3b8hyyr	179	7	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	179	8	complicatious	complicatious	NN
cord-006860-a3b8hyyr	179	9	,	,	,
cord-006860-a3b8hyyr	179	10	clinically	clinically	RB
cord-006860-a3b8hyyr	179	11	~t	~t	RB
cord-006860-a3b8hyyr	179	12	bleeding	bleed	VBG
cord-006860-a3b8hyyr	179	13	,	,	,
cord-006860-a3b8hyyr	179	14	and	and	CC
cord-006860-a3b8hyyr	179	15	mortality	mortality	NN
cord-006860-a3b8hyyr	179	16	varied	varied	JJ
cord-006860-a3b8hyyr	179	17	firom	firom	NN
cord-006860-a3b8hyyr	179	18	20.60	20.60	CD
cord-006860-a3b8hyyr	179	19	%	%	NN
cord-006860-a3b8hyyr	180	1	aad	aad	NNP
cord-006860-a3b8hyyr	180	2	were	be	VBD
cord-006860-a3b8hyyr	180	3	all	all	DT
cord-006860-a3b8hyyr	180	4	statistically	statistically	RB
cord-006860-a3b8hyyr	180	5	significantly	significantly	RB
cord-006860-a3b8hyyr	180	6	in	in	IN
cord-006860-a3b8hyyr	180	7	favor	favor	NN
cord-006860-a3b8hyyr	180	8	of	of	IN
cord-006860-a3b8hyyr	180	9	low	low	JJ
cord-006860-a3b8hyyr	180	10	-	-	HYPH
cord-006860-a3b8hyyr	180	11	molecular	molecular	JJ
cord-006860-a3b8hyyr	180	12	-	-	HYPH
cord-006860-a3b8hyyr	180	13	wedght	wedght	NN
cord-006860-a3b8hyyr	180	14	hqtmrin	hqtmrin	NNP
cord-006860-a3b8hyyr	180	15	.	.	.
cord-006860-a3b8hyyr	181	1	Coadusions	coadusion	NNS
cord-006860-a3b8hyyr	181	2	:	:	:
cord-006860-a3b8hyyr	181	3	Low	low	JJ
cord-006860-a3b8hyyr	181	4	-	-	HYPH
cord-006860-a3b8hyyr	181	5	mol	mol	NN
cord-006860-a3b8hyyr	181	6	~	~	NFP
cord-006860-a3b8hyyr	181	7	ular	ular	JJ
cord-006860-a3b8hyyr	181	8	--	--	:
cord-006860-a3b8hyyr	181	9	weight	weight	NN
cord-006860-a3b8hyyr	181	10	hoparim	hoparim	NNP
cord-006860-a3b8hyyr	181	11	administered	administer	VBN
cord-006860-a3b8hyyr	181	12	subcutaneously	subcutaneously	RB
cord-006860-a3b8hyyr	181	13	in	in	IN
cord-006860-a3b8hyyr	181	14	fixed	fix	VBN
cord-006860-a3b8hyyr	181	15	doses	dose	NNS
cord-006860-a3b8hyyr	181	16	adjusted	adjust	VBN
cord-006860-a3b8hyyr	181	17	for	for	IN
cord-006860-a3b8hyyr	181	18	body	body	NN
cord-006860-a3b8hyyr	181	19	weight	weight	NN
cord-006860-a3b8hyyr	181	20	aml	aml	NNP
cord-006860-a3b8hyyr	181	21	without	without	IN
cord-006860-a3b8hyyr	181	22	laboratory	laboratory	NN
cord-006860-a3b8hyyr	182	1	nmaitori~	nmaitori~	NNP
cord-006860-a3b8hyyr	182	2	=	=	-LRB-
cord-006860-a3b8hyyr	182	3	re	re	VBP
cord-006860-a3b8hyyr	182	4	more	more	RBR
cord-006860-a3b8hyyr	182	5	effective	effective	JJ
cord-006860-a3b8hyyr	182	6	and	and	CC
cord-006860-a3b8hyyr	182	7	safea	safea	NNP
cord-006860-a3b8hyyr	182	8	"	"	''
cord-006860-a3b8hyyr	182	9	tlum	tlum	NNP
cord-006860-a3b8hyyr	183	1	adjn~_-dose	adjn~_-dose	NNP
cord-006860-a3b8hyyr	184	1	standard	standard	JJ
cord-006860-a3b8hyyr	184	2	h~.	h~.	NNP
cord-006860-a3b8hyyr	184	3	sauce	sauce	NN
cord-006860-a3b8hyyr	184	4	low	low	JJ
cord-006860-a3b8hyyr	184	5	molec~	molec~	NN
cord-006860-a3b8hyyr	185	1	dar	dar	NNP
cord-006860-a3b8hyyr	185	2	weight	weight	NNP
cord-006860-a3b8hyyr	185	3	hqmrim	hqmrim	NNP
cord-006860-a3b8hyyr	185	4	vary	vary	VBP
cord-006860-a3b8hyyr	185	5	in	in	IN
cord-006860-a3b8hyyr	185	6	o	o	NN
cord-006860-a3b8hyyr	185	7	~	~	NFP
cord-006860-a3b8hyyr	185	8	apositiou	apositiou	NNP
cord-006860-a3b8hyyr	185	9	=	=	SYM
cord-006860-a3b8hyyr	185	10	ad	ad	NN
cord-006860-a3b8hyyr	185	11	pharma	pharma	NNP
cord-006860-a3b8hyyr	185	12	~	~	NFP
cord-006860-a3b8hyyr	185	13	ogical	ogical	NNP
cord-006860-a3b8hyyr	185	14	Im)fil~	Im)fil~	NNP
cord-006860-a3b8hyyr	186	1	the	the	DT
cord-006860-a3b8hyyr	186	2	benefits	benefit	NNS
cord-006860-a3b8hyyr	186	3	of	of	IN
cord-006860-a3b8hyyr	186	4	each	each	DT
cord-006860-a3b8hyyr	186	5	~	~	NFP
cord-006860-a3b8hyyr	187	1	shodd	shodd	NNP
cord-006860-a3b8hyyr	187	2	~tabllsbcd	~tabllsbcd	NFP
cord-006860-a3b8hyyr	187	3	separately	separately	RB
cord-006860-a3b8hyyr	187	4	.	.	.
cord-006860-a3b8hyyr	188	1	Unfraetionated	unfraetionate	VBN
cord-006860-a3b8hyyr	188	2	hcparin	hcparin	NNP
cord-006860-a3b8hyyr	188	3	(	(	-LRB-
cord-006860-a3b8hyyr	188	4	UH	uh	UH
cord-006860-a3b8hyyr	188	5	)	)	-RRB-
cord-006860-a3b8hyyr	188	6	and	and	CC
cord-006860-a3b8hyyr	188	7	low	low	JJ
cord-006860-a3b8hyyr	188	8	molecular	molecular	JJ
cord-006860-a3b8hyyr	188	9	weight	weight	NN
cord-006860-a3b8hyyr	188	10	heparin	heparin	NN
cord-006860-a3b8hyyr	188	11	(	(	-LRB-
cord-006860-a3b8hyyr	188	12	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	188	13	)	)	-RRB-
cord-006860-a3b8hyyr	188	14	are	be	VBP
cord-006860-a3b8hyyr	188	15	widely	widely	RB
cord-006860-a3b8hyyr	188	16	used	use	VBN
cord-006860-a3b8hyyr	188	17	for	for	IN
cord-006860-a3b8hyyr	188	18	the	the	DT
cord-006860-a3b8hyyr	188	19	prevention	prevention	NN
cord-006860-a3b8hyyr	188	20	and	and	CC
cord-006860-a3b8hyyr	188	21	treatment	treatment	NN
cord-006860-a3b8hyyr	188	22	of	of	IN
cord-006860-a3b8hyyr	188	23	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	188	24	disorders	disorder	NNS
cord-006860-a3b8hyyr	188	25	.	.	.
cord-006860-a3b8hyyr	189	1	UH	UH	NNP
cord-006860-a3b8hyyr	189	2	and	and	CC
cord-006860-a3b8hyyr	189	3	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	189	4	induce	induce	VBP
cord-006860-a3b8hyyr	189	5	platelet	platelet	NN
cord-006860-a3b8hyyr	189	6	aggregation	aggregation	NN
cord-006860-a3b8hyyr	189	7	in	in	IN
cord-006860-a3b8hyyr	189	8	vitro	vitro	FW
cord-006860-a3b8hyyr	189	9	.	.	.
cord-006860-a3b8hyyr	190	1	RGD	RGD	NNP
cord-006860-a3b8hyyr	190	2	peptides	peptide	NNS
cord-006860-a3b8hyyr	190	3	compete	compete	VBP
cord-006860-a3b8hyyr	190	4	with	with	IN
cord-006860-a3b8hyyr	190	5	fibrinogm	fibrinogm	NNP
cord-006860-a3b8hyyr	190	6	for	for	IN
cord-006860-a3b8hyyr	190	7	the	the	DT
cord-006860-a3b8hyyr	190	8	binding	binding	NN
cord-006860-a3b8hyyr	190	9	to	to	IN
cord-006860-a3b8hyyr	190	10	the	the	DT
cord-006860-a3b8hyyr	190	11	glycoprotein	glycoprotein	NN
cord-006860-a3b8hyyr	190	12	receptor	receptor	NN
cord-006860-a3b8hyyr	190	13	(	(	-LRB-
cord-006860-a3b8hyyr	190	14	GP	GP	NNP
cord-006860-a3b8hyyr	190	15	lib	lib	NNP
cord-006860-a3b8hyyr	190	16	-	-	HYPH
cord-006860-a3b8hyyr	190	17	Ilia	Ilia	NNP
cord-006860-a3b8hyyr	190	18	)	)	-RRB-
cord-006860-a3b8hyyr	190	19	of	of	IN
cord-006860-a3b8hyyr	190	20	platelets	platelet	NNS
cord-006860-a3b8hyyr	190	21	and	and	CC
cord-006860-a3b8hyyr	190	22	inhibit	inhibit	VBP
cord-006860-a3b8hyyr	190	23	platelet	platelet	NN
cord-006860-a3b8hyyr	190	24	aggregation	aggregation	NN
cord-006860-a3b8hyyr	190	25	.	.	.
cord-006860-a3b8hyyr	191	1	To	to	TO
cord-006860-a3b8hyyr	191	2	inhibit	inhibit	VB
cord-006860-a3b8hyyr	191	3	the	the	DT
cord-006860-a3b8hyyr	191	4	heparin	heparin	NN
cord-006860-a3b8hyyr	191	5	-	-	HYPH
cord-006860-a3b8hyyr	191	6	indueed	indueed	NN
cord-006860-a3b8hyyr	191	7	platelet	platelet	NN
cord-006860-a3b8hyyr	191	8	~tion	~tion	NNP
cord-006860-a3b8hyyr	191	9	and	and	CC
cord-006860-a3b8hyyr	191	10	prolong	prolong	VB
cord-006860-a3b8hyyr	191	11	the	the	DT
cord-006860-a3b8hyyr	191	12	half	half	JJ
cord-006860-a3b8hyyr	191	13	-	-	HYPH
cord-006860-a3b8hyyr	191	14	life	life	NN
cord-006860-a3b8hyyr	191	15	in	in	IN
cord-006860-a3b8hyyr	191	16	blood	blood	NN
cord-006860-a3b8hyyr	191	17	of	of	IN
cord-006860-a3b8hyyr	191	18	RGD	RGD	NNP
cord-006860-a3b8hyyr	191	19	peptides	peptide	NNS
cord-006860-a3b8hyyr	191	20	,	,	,
cord-006860-a3b8hyyr	191	21	we	-PRON-	PRP
cord-006860-a3b8hyyr	191	22	linked	link	VBD
cord-006860-a3b8hyyr	191	23	Ac	Ac	NNP
cord-006860-a3b8hyyr	191	24	-	-	HYPH
cord-006860-a3b8hyyr	191	25	RGDV	RGDV	NNP
cord-006860-a3b8hyyr	191	26	-	-	HYPH
cord-006860-a3b8hyyr	191	27	SSGGS	SSGGS	NNP
cord-006860-a3b8hyyr	191	28	-	-	HYPH
cord-006860-a3b8hyyr	191	29	Ahx	Ahx	NNP
cord-006860-a3b8hyyr	191	30	-	-	HYPH
cord-006860-a3b8hyyr	191	31	YK	YK	NNP
cord-006860-a3b8hyyr	191	32	eovalently	eovalently	RB
cord-006860-a3b8hyyr	191	33	to	to	IN
cord-006860-a3b8hyyr	191	34	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	191	35	in	in	IN
cord-006860-a3b8hyyr	191	36	a	a	DT
cord-006860-a3b8hyyr	191	37	ratio	ratio	NN
cord-006860-a3b8hyyr	191	38	1:1	1:1	CD
cord-006860-a3b8hyyr	191	39	.	.	.
cord-006860-a3b8hyyr	192	1	The	the	DT
cord-006860-a3b8hyyr	192	2	peptide	peptide	NN
cord-006860-a3b8hyyr	192	3	is	be	VBZ
cord-006860-a3b8hyyr	192	4	composed	compose	VBN
cord-006860-a3b8hyyr	192	5	of	of	IN
cord-006860-a3b8hyyr	192	6	three	three	CD
cord-006860-a3b8hyyr	192	7	regions	region	NNS
cord-006860-a3b8hyyr	192	8	:	:	:
cord-006860-a3b8hyyr	193	1	A.	A.	NNP
cord-006860-a3b8hyyr	193	2	RGD	RGD	NNP
cord-006860-a3b8hyyr	193	3	-	-	:
cord-006860-a3b8hyyr	193	4	gives	give	VBZ
cord-006860-a3b8hyyr	193	5	the	the	DT
cord-006860-a3b8hyyr	193	6	specificity	specificity	NN
cord-006860-a3b8hyyr	193	7	for	for	IN
cord-006860-a3b8hyyr	193	8	the	the	DT
cord-006860-a3b8hyyr	193	9	receptor	receptor	NN
cord-006860-a3b8hyyr	193	10	GP	GP	NNP
cord-006860-a3b8hyyr	193	11	lib	lib	NNP
cord-006860-a3b8hyyr	193	12	-	-	HYPH
cord-006860-a3b8hyyr	193	13	Ilia	Ilia	NNP
cord-006860-a3b8hyyr	193	14	;	;	:
cord-006860-a3b8hyyr	193	15	B	b	NN
cord-006860-a3b8hyyr	193	16	..	..	NFP
cord-006860-a3b8hyyr	193	17	SSGGS	SSGGS	NNP
cord-006860-a3b8hyyr	193	18	-	-	HYPH
cord-006860-a3b8hyyr	193	19	Ahx	Ahx	NNP
cord-006860-a3b8hyyr	193	20	-	-	:
cord-006860-a3b8hyyr	193	21	is	be	VBZ
cord-006860-a3b8hyyr	193	22	the	the	DT
cord-006860-a3b8hyyr	193	23	spacer	spacer	NN
cord-006860-a3b8hyyr	193	24	between	between	IN
cord-006860-a3b8hyyr	193	25	carrier	carrier	NN
cord-006860-a3b8hyyr	193	26	and	and	CC
cord-006860-a3b8hyyr	193	27	ligand	ligand	NN
cord-006860-a3b8hyyr	193	28	,	,	,
cord-006860-a3b8hyyr	193	29	which	which	WDT
cord-006860-a3b8hyyr	193	30	should	should	MD
cord-006860-a3b8hyyr	193	31	facilitate	facilitate	VB
cord-006860-a3b8hyyr	193	32	the	the	DT
cord-006860-a3b8hyyr	193	33	intnraetion	intnraetion	NN
cord-006860-a3b8hyyr	193	34	between	between	IN
cord-006860-a3b8hyyr	193	35	the	the	DT
cord-006860-a3b8hyyr	193	36	conjugate	conjugate	NN
cord-006860-a3b8hyyr	193	37	and	and	CC
cord-006860-a3b8hyyr	193	38	the	the	DT
cord-006860-a3b8hyyr	193	39	GP	GP	NNP
cord-006860-a3b8hyyr	193	40	lib	lib	NN
cord-006860-a3b8hyyr	193	41	-	-	HYPH
cord-006860-a3b8hyyr	193	42	Ills	Ills	NNP
cord-006860-a3b8hyyr	193	43	receptor	receptor	NN
cord-006860-a3b8hyyr	193	44	;	;	:
cord-006860-a3b8hyyr	193	45	C.	C.	NNP
cord-006860-a3b8hyyr	193	46	-YK	-yk	JJ
cord-006860-a3b8hyyr	193	47	arc	arc	NNP
cord-006860-a3b8hyyr	193	48	functional	functional	JJ
cord-006860-a3b8hyyr	193	49	antino	antino	NN
cord-006860-a3b8hyyr	193	50	acids	acid	NNS
cord-006860-a3b8hyyr	193	51	for	for	IN
cord-006860-a3b8hyyr	193	52	iodination	iodination	NN
cord-006860-a3b8hyyr	193	53	(	(	-LRB-
cord-006860-a3b8hyyr	193	54	Y	Y	NNP
cord-006860-a3b8hyyr	193	55	)	)	-RRB-
cord-006860-a3b8hyyr	193	56	and	and	CC
cord-006860-a3b8hyyr	193	57	for	for	IN
cord-006860-a3b8hyyr	193	58	covalent	covalent	JJ
cord-006860-a3b8hyyr	193	59	attachment	attachment	NN
cord-006860-a3b8hyyr	193	60	(	(	-LRB-
cord-006860-a3b8hyyr	193	61	K	K	NNP
cord-006860-a3b8hyyr	193	62	)	)	-RRB-
cord-006860-a3b8hyyr	193	63	to	to	IN
cord-006860-a3b8hyyr	193	64	the	the	DT
cord-006860-a3b8hyyr	193	65	cattier	cattier	NNP
cord-006860-a3b8hyyr	193	66	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	193	67	.	.	.
cord-006860-a3b8hyyr	194	1	The	the	DT
cord-006860-a3b8hyyr	194	2	aggregation	aggregation	NN
cord-006860-a3b8hyyr	194	3	achieved	achieve	VBN
cord-006860-a3b8hyyr	194	4	with	with	IN
cord-006860-a3b8hyyr	194	5	different	different	JJ
cord-006860-a3b8hyyr	194	6	concentrations	concentration	NNS
cord-006860-a3b8hyyr	194	7	of	of	IN
cord-006860-a3b8hyyr	194	8	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	194	9	,	,	,
cord-006860-a3b8hyyr	194	10	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	194	11	-	-	HYPH
cord-006860-a3b8hyyr	194	12	eonjugate	eonjugate	NNP
cord-006860-a3b8hyyr	194	13	and	and	CC
cord-006860-a3b8hyyr	194	14	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	195	1	/RGD	/rgd	LS
cord-006860-a3b8hyyr	195	2	-	-	HYPH
cord-006860-a3b8hyyr	195	3	peptide	peptide	JJ
cord-006860-a3b8hyyr	195	4	mixture	mixture	NN
cord-006860-a3b8hyyr	195	5	in	in	IN
cord-006860-a3b8hyyr	195	6	a	a	DT
cord-006860-a3b8hyyr	195	7	ratio	ratio	NN
cord-006860-a3b8hyyr	195	8	1:1	1:1	CD
cord-006860-a3b8hyyr	195	9	was	be	VBD
cord-006860-a3b8hyyr	195	10	mea.~ared	mea.~are	VBN
cord-006860-a3b8hyyr	195	11	after	after	IN
cord-006860-a3b8hyyr	195	12	20	20	CD
cord-006860-a3b8hyyr	195	13	rain	rain	NN
cord-006860-a3b8hyyr	195	14	.	.	.
cord-006860-a3b8hyyr	196	1	;	;	:
cord-006860-a3b8hyyr	196	2	maximum	maximum	JJ
cord-006860-a3b8hyyr	196	3	aggregation	aggregation	NN
cord-006860-a3b8hyyr	196	4	after	after	IN
cord-006860-a3b8hyyr	196	5	platelet	platelet	NN
cord-006860-a3b8hyyr	196	6	activation	activation	NN
cord-006860-a3b8hyyr	196	7	with	with	IN
cord-006860-a3b8hyyr	196	8	10	10	CD
cord-006860-a3b8hyyr	196	9	pM	pm	NN
cord-006860-a3b8hyyr	197	1	ADP	ADP	NNP
cord-006860-a3b8hyyr	197	2	was	be	VBD
cord-006860-a3b8hyyr	197	3	set	set	VBN
cord-006860-a3b8hyyr	197	4	equal	equal	JJ
cord-006860-a3b8hyyr	197	5	to	to	IN
cord-006860-a3b8hyyr	197	6	100	100	CD
cord-006860-a3b8hyyr	197	7	%	%	NN
cord-006860-a3b8hyyr	197	8	.	.	.
cord-006860-a3b8hyyr	198	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	198	2	aggregation	aggregation	NN
cord-006860-a3b8hyyr	198	3	in	in	IN
cord-006860-a3b8hyyr	198	4	normal	normal	JJ
cord-006860-a3b8hyyr	198	5	human	human	JJ
cord-006860-a3b8hyyr	198	6	plateletrich	plateletrich	NNP
cord-006860-a3b8hyyr	198	7	eitrated	eitrated	JJ
cord-006860-a3b8hyyr	198	8	plasma	plasma	NN
cord-006860-a3b8hyyr	198	9	(	(	-LRB-
cord-006860-a3b8hyyr	198	10	PRP	prp	NN
cord-006860-a3b8hyyr	198	11	;	;	:
cord-006860-a3b8hyyr	198	12	220	220	CD
cord-006860-a3b8hyyr	198	13	000	000	CD
cord-006860-a3b8hyyr	198	14	/	/	SYM
cord-006860-a3b8hyyr	198	15	p.l	p.l	NN
cord-006860-a3b8hyyr	198	16	)	)	-RRB-
cord-006860-a3b8hyyr	198	17	was	be	VBD
cord-006860-a3b8hyyr	198	18	induced	induce	VBN
cord-006860-a3b8hyyr	198	19	by	by	IN
cord-006860-a3b8hyyr	198	20	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	198	21	in	in	IN
cord-006860-a3b8hyyr	198	22	a	a	DT
cord-006860-a3b8hyyr	198	23	dose	dose	NN
cord-006860-a3b8hyyr	198	24	~ndent	~ndent	CD
cord-006860-a3b8hyyr	198	25	manner	manner	NN
cord-006860-a3b8hyyr	198	26	.	.	.
cord-006860-a3b8hyyr	199	1	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	199	2	can	can	MD
cord-006860-a3b8hyyr	199	3	induce	induce	VB
cord-006860-a3b8hyyr	199	4	antbodies	antbodie	NNS
cord-006860-a3b8hyyr	199	5	which	which	WDT
cord-006860-a3b8hyyr	199	6	interact	interact	VBP
cord-006860-a3b8hyyr	199	7	with	with	IN
cord-006860-a3b8hyyr	199	8	platelets	platelet	NNS
cord-006860-a3b8hyyr	199	9	and	and	CC
cord-006860-a3b8hyyr	199	10	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	199	11	cells	cell	NNS
cord-006860-a3b8hyyr	199	12	.	.	.
cord-006860-a3b8hyyr	200	1	This	this	DT
cord-006860-a3b8hyyr	200	2	causes	cause	VBZ
cord-006860-a3b8hyyr	200	3	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	200	4	and	and	CC
cord-006860-a3b8hyyr	200	5	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	200	6	complications	complication	NNS
cord-006860-a3b8hyyr	200	7	.	.	.
cord-006860-a3b8hyyr	201	1	HITpatients	hitpatient	NNS
cord-006860-a3b8hyyr	201	2	do	do	VBP
cord-006860-a3b8hyyr	201	3	need	need	VB
cord-006860-a3b8hyyr	201	4	effective	effective	JJ
cord-006860-a3b8hyyr	201	5	parenteral	parenteral	JJ
cord-006860-a3b8hyyr	201	6	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	201	7	.	.	.
cord-006860-a3b8hyyr	202	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	202	2	treated	treat	VBD
cord-006860-a3b8hyyr	202	3	82	82	CD
cord-006860-a3b8hyyr	202	4	patients	patient	NNS
cord-006860-a3b8hyyr	202	5	(	(	-LRB-
cord-006860-a3b8hyyr	202	6	30m,52fm	30m,52fm	CD
cord-006860-a3b8hyyr	202	7	)	)	-RRB-
cord-006860-a3b8hyyr	202	8	,	,	,
cord-006860-a3b8hyyr	202	9	median	median	JJ
cord-006860-a3b8hyyr	202	10	age	age	NN
cord-006860-a3b8hyyr	202	11	61	61	CD
cord-006860-a3b8hyyr	202	12	years	year	NNS
cord-006860-a3b8hyyr	202	13	(	(	-LRB-
cord-006860-a3b8hyyr	202	14	18	18	CD
cord-006860-a3b8hyyr	202	15	-	-	SYM
cord-006860-a3b8hyyr	202	16	84	84	CD
cord-006860-a3b8hyyr	202	17	)	)	-RRB-
cord-006860-a3b8hyyr	202	18	with	with	IN
cord-006860-a3b8hyyr	202	19	laboratory	laboratory	NN
cord-006860-a3b8hyyr	202	20	prooven	prooven	VBN
cord-006860-a3b8hyyr	202	21	HIT	HIT	NNP
cord-006860-a3b8hyyr	202	22	(	(	-LRB-
cord-006860-a3b8hyyr	202	23	HIPA	HIPA	NNP
cord-006860-a3b8hyyr	202	24	-	-	HYPH
cord-006860-a3b8hyyr	202	25	Test	Test	NNP
cord-006860-a3b8hyyr	202	26	)	)	-RRB-
cord-006860-a3b8hyyr	202	27	with	with	IN
cord-006860-a3b8hyyr	202	28	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	202	29	(	(	-LRB-
cord-006860-a3b8hyyr	202	30	r-)hirudin	r-)hirudin	NN
cord-006860-a3b8hyyr	202	31	.	.	.
cord-006860-a3b8hyyr	203	1	As	as	IN
cord-006860-a3b8hyyr	203	2	these	these	DT
cord-006860-a3b8hyyr	203	3	patients	patient	NNS
cord-006860-a3b8hyyr	203	4	had	have	VBD
cord-006860-a3b8hyyr	203	5	been	be	VBN
cord-006860-a3b8hyyr	203	6	preseleeted	preseleete	VBN
cord-006860-a3b8hyyr	203	7	by	by	IN
cord-006860-a3b8hyyr	203	8	their	-PRON-	PRP$
cord-006860-a3b8hyyr	203	9	immunological	immunological	JJ
cord-006860-a3b8hyyr	203	10	response	response	NN
cord-006860-a3b8hyyr	203	11	during	during	IN
cord-006860-a3b8hyyr	203	12	heparin	heparin	JJ
cord-006860-a3b8hyyr	203	13	treatment	treatment	NN
cord-006860-a3b8hyyr	203	14	and	and	CC
cord-006860-a3b8hyyr	203	15	the	the	DT
cord-006860-a3b8hyyr	203	16	treatment	treatment	NN
cord-006860-a3b8hyyr	203	17	duration	duration	NN
cord-006860-a3b8hyyr	203	18	of	of	IN
cord-006860-a3b8hyyr	203	19	the	the	DT
cord-006860-a3b8hyyr	203	20	study	study	NN
cord-006860-a3b8hyyr	203	21	was	be	VBD
cord-006860-a3b8hyyr	203	22	longer	long	JJR
cord-006860-a3b8hyyr	203	23	than	than	IN
cord-006860-a3b8hyyr	203	24	in	in	IN
cord-006860-a3b8hyyr	203	25	any	any	DT
cord-006860-a3b8hyyr	203	26	other	other	JJ
cord-006860-a3b8hyyr	203	27	study	study	NN
cord-006860-a3b8hyyr	203	28	using	use	VBG
cord-006860-a3b8hyyr	203	29	thlrudin	thlrudin	NNS
cord-006860-a3b8hyyr	203	30	,	,	,
cord-006860-a3b8hyyr	203	31	all	all	DT
cord-006860-a3b8hyyr	203	32	patient	patient	NN
cord-006860-a3b8hyyr	203	33	samples	sample	NNS
cord-006860-a3b8hyyr	203	34	were	be	VBD
cord-006860-a3b8hyyr	203	35	investigated	investigate	VBN
cord-006860-a3b8hyyr	203	36	for	for	IN
cord-006860-a3b8hyyr	203	37	anti	anti	JJ
cord-006860-a3b8hyyr	203	38	-	-	JJ
cord-006860-a3b8hyyr	203	39	r	r	JJ
cord-006860-a3b8hyyr	203	40	-	-	HYPH
cord-006860-a3b8hyyr	203	41	hirudin	hirudin	NN
cord-006860-a3b8hyyr	203	42	antibodies	antibody	NNS
cord-006860-a3b8hyyr	204	1	Himdin	Himdin	NNP
cord-006860-a3b8hyyr	204	2	antibodies	antibody	NNS
cord-006860-a3b8hyyr	204	3	were	be	VBD
cord-006860-a3b8hyyr	204	4	screened	screen	VBN
cord-006860-a3b8hyyr	204	5	by	by	IN
cord-006860-a3b8hyyr	204	6	a	a	DT
cord-006860-a3b8hyyr	204	7	sandwich	sandwich	NN
cord-006860-a3b8hyyr	204	8	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	204	9	using	use	VBG
cord-006860-a3b8hyyr	204	10	r	r	NN
cord-006860-a3b8hyyr	204	11	-	-	HYPH
cord-006860-a3b8hyyr	204	12	hirudin	hirudin	RB
cord-006860-a3b8hyyr	204	13	fixed	fix	VBN
cord-006860-a3b8hyyr	204	14	to	to	IN
cord-006860-a3b8hyyr	204	15	the	the	DT
cord-006860-a3b8hyyr	204	16	solid	solid	JJ
cord-006860-a3b8hyyr	204	17	phase	phase	NN
cord-006860-a3b8hyyr	204	18	as	as	IN
cord-006860-a3b8hyyr	204	19	antigen	antigen	NN
cord-006860-a3b8hyyr	204	20	.	.	.
cord-006860-a3b8hyyr	205	1	All	all	DT
cord-006860-a3b8hyyr	205	2	plasma	plasma	NN
cord-006860-a3b8hyyr	205	3	samples	sample	NNS
cord-006860-a3b8hyyr	205	4	were	be	VBD
cord-006860-a3b8hyyr	205	5	screened	screen	VBN
cord-006860-a3b8hyyr	205	6	for	for	IN
cord-006860-a3b8hyyr	205	7	anti	anti	JJ
cord-006860-a3b8hyyr	205	8	-	-	JJ
cord-006860-a3b8hyyr	205	9	Hirudin	hirudin	JJ
cord-006860-a3b8hyyr	205	10	antibodies	antibody	NNS
cord-006860-a3b8hyyr	205	11	of	of	IN
cord-006860-a3b8hyyr	205	12	the	the	DT
cord-006860-a3b8hyyr	205	13	IgG	IgG	NNP
cord-006860-a3b8hyyr	205	14	class	class	NN
cord-006860-a3b8hyyr	205	15	,	,	,
cord-006860-a3b8hyyr	205	16	but	but	CC
cord-006860-a3b8hyyr	205	17	solar	solar	NN
cord-006860-a3b8hyyr	205	18	only	only	RB
cord-006860-a3b8hyyr	205	19	a	a	DT
cord-006860-a3b8hyyr	205	20	suset	suset	NN
cord-006860-a3b8hyyr	205	21	of	of	IN
cord-006860-a3b8hyyr	205	22	samples	sample	NNS
cord-006860-a3b8hyyr	205	23	for	for	IN
cord-006860-a3b8hyyr	205	24	lgE	lge	JJ
cord-006860-a3b8hyyr	205	25	anti	anti	JJ
cord-006860-a3b8hyyr	205	26	-	-	JJ
cord-006860-a3b8hyyr	205	27	r	r	JJ
cord-006860-a3b8hyyr	205	28	-	-	HYPH
cord-006860-a3b8hyyr	205	29	himdin	himdin	NN
cord-006860-a3b8hyyr	205	30	antibodies	antibody	NNS
cord-006860-a3b8hyyr	205	31	.	.	.
cord-006860-a3b8hyyr	206	1	38	38	CD
cord-006860-a3b8hyyr	206	2	of	of	IN
cord-006860-a3b8hyyr	206	3	82	82	CD
cord-006860-a3b8hyyr	206	4	patients	patient	NNS
cord-006860-a3b8hyyr	206	5	(	(	-LRB-
cord-006860-a3b8hyyr	206	6	46.3	46.3	CD
cord-006860-a3b8hyyr	206	7	%	%	NN
cord-006860-a3b8hyyr	206	8	)	)	-RRB-
cord-006860-a3b8hyyr	206	9	developed	develop	VBN
cord-006860-a3b8hyyr	206	10	anti	anti	NN
cord-006860-a3b8hyyr	206	11	-	-	JJ
cord-006860-a3b8hyyr	206	12	hirudin	hirudin	JJ
cord-006860-a3b8hyyr	206	13	antibodies	antibody	NNS
cord-006860-a3b8hyyr	206	14	of	of	IN
cord-006860-a3b8hyyr	206	15	the	the	DT
cord-006860-a3b8hyyr	206	16	IgG	IgG	NNP
cord-006860-a3b8hyyr	206	17	class	class	NN
cord-006860-a3b8hyyr	206	18	.	.	.
cord-006860-a3b8hyyr	207	1	Anti	anti	JJ
cord-006860-a3b8hyyr	207	2	-	-	JJ
cord-006860-a3b8hyyr	207	3	hirudin	hirudin	JJ
cord-006860-a3b8hyyr	207	4	antibodies	antibody	NNS
cord-006860-a3b8hyyr	207	5	were	be	VBD
cord-006860-a3b8hyyr	207	6	not	not	RB
cord-006860-a3b8hyyr	207	7	detectable	detectable	JJ
cord-006860-a3b8hyyr	207	8	not	not	RB
cord-006860-a3b8hyyr	207	9	before	before	IN
cord-006860-a3b8hyyr	207	10	6	6	CD
cord-006860-a3b8hyyr	207	11	days	day	NNS
cord-006860-a3b8hyyr	207	12	of	of	IN
cord-006860-a3b8hyyr	207	13	r	r	NN
cord-006860-a3b8hyyr	207	14	-	-	HYPH
cord-006860-a3b8hyyr	207	15	hirudin	hirudin	NN
cord-006860-a3b8hyyr	207	16	administration	administration	NN
cord-006860-a3b8hyyr	207	17	Solar	Solar	NNP
cord-006860-a3b8hyyr	207	18	no	no	DT
cord-006860-a3b8hyyr	207	19	IgE	IgE	NNP
cord-006860-a3b8hyyr	207	20	anti	anti	NN
cord-006860-a3b8hyyr	207	21	-	-	JJ
cord-006860-a3b8hyyr	207	22	hirudin	hirudin	JJ
cord-006860-a3b8hyyr	207	23	antibodies	antibody	NNS
cord-006860-a3b8hyyr	207	24	were	be	VBD
cord-006860-a3b8hyyr	207	25	found	find	VBN
cord-006860-a3b8hyyr	207	26	.	.	.
cord-006860-a3b8hyyr	208	1	None	none	NN
cord-006860-a3b8hyyr	208	2	of	of	IN
cord-006860-a3b8hyyr	208	3	the	the	DT
cord-006860-a3b8hyyr	208	4	patients	patient	NNS
cord-006860-a3b8hyyr	208	5	devdoped	devdope	VBD
cord-006860-a3b8hyyr	208	6	thromboeytopenia	thromboeytopenia	NNP
cord-006860-a3b8hyyr	208	7	or	or	CC
cord-006860-a3b8hyyr	208	8	allergic	allergic	JJ
cord-006860-a3b8hyyr	208	9	symptoms	symptom	NNS
cord-006860-a3b8hyyr	208	10	.	.	.
cord-006860-a3b8hyyr	209	1	However	however	RB
cord-006860-a3b8hyyr	209	2	,	,	,
cord-006860-a3b8hyyr	209	3	in	in	IN
cord-006860-a3b8hyyr	209	4	a	a	DT
cord-006860-a3b8hyyr	209	5	subset	subset	NN
cord-006860-a3b8hyyr	209	6	of	of	IN
cord-006860-a3b8hyyr	209	7	patients	patient	NNS
cord-006860-a3b8hyyr	209	8	the	the	DT
cord-006860-a3b8hyyr	209	9	anti	anti	NN
cord-006860-a3b8hyyr	209	10	-	-	JJ
cord-006860-a3b8hyyr	209	11	hirudin	hirudin	JJ
cord-006860-a3b8hyyr	209	12	antibodies	antibody	NNS
cord-006860-a3b8hyyr	209	13	enhanced	enhance	VBD
cord-006860-a3b8hyyr	209	14	the	the	DT
cord-006860-a3b8hyyr	209	15	anticoagulatory	anticoagulatory	NN
cord-006860-a3b8hyyr	209	16	effect	effect	NN
cord-006860-a3b8hyyr	209	17	of	of	IN
cord-006860-a3b8hyyr	209	18	r	r	NN
cord-006860-a3b8hyyr	209	19	-	-	:
cord-006860-a3b8hyyr	209	20	hirudin	hirudin	NN
cord-006860-a3b8hyyr	209	21	.	.	.
cord-006860-a3b8hyyr	210	1	In	in	IN
cord-006860-a3b8hyyr	210	2	5	5	CD
cord-006860-a3b8hyyr	210	3	patients	patient	NNS
cord-006860-a3b8hyyr	210	4	the	the	DT
cord-006860-a3b8hyyr	210	5	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	210	6	dosage	dosage	NN
cord-006860-a3b8hyyr	210	7	had	have	VBD
cord-006860-a3b8hyyr	210	8	to	to	TO
cord-006860-a3b8hyyr	210	9	be	be	VB
cord-006860-a3b8hyyr	210	10	decreased	decrease	VBN
cord-006860-a3b8hyyr	210	11	by	by	IN
cord-006860-a3b8hyyr	210	12	2	2	CD
cord-006860-a3b8hyyr	210	13	-	-	SYM
cord-006860-a3b8hyyr	210	14	3	3	CD
cord-006860-a3b8hyyr	210	15	fold	fold	VBP
cord-006860-a3b8hyyr	210	16	to	to	TO
cord-006860-a3b8hyyr	210	17	maintain	maintain	VB
cord-006860-a3b8hyyr	210	18	a	a	DT
cord-006860-a3b8hyyr	210	19	stable	stable	JJ
cord-006860-a3b8hyyr	210	20	aPTT	aptt	JJ
cord-006860-a3b8hyyr	210	21	level	level	NN
cord-006860-a3b8hyyr	210	22	,	,	,
cord-006860-a3b8hyyr	210	23	in	in	IN
cord-006860-a3b8hyyr	210	24	3	3	CD
cord-006860-a3b8hyyr	210	25	patients	patient	NNS
cord-006860-a3b8hyyr	210	26	,	,	,
cord-006860-a3b8hyyr	210	27	despite	despite	IN
cord-006860-a3b8hyyr	211	1	stable	stable	JJ
cord-006860-a3b8hyyr	211	2	r	r	NN
cord-006860-a3b8hyyr	211	3	-	-	HYPH
cord-006860-a3b8hyyr	211	4	hirudin	hirudin	NN
cord-006860-a3b8hyyr	211	5	maintenance	maintenance	NN
cord-006860-a3b8hyyr	211	6	dose	dose	VBD
cord-006860-a3b8hyyr	211	7	the	the	DT
cord-006860-a3b8hyyr	211	8	aPTT	aptt	NN
cord-006860-a3b8hyyr	211	9	increased	increase	VBD
cord-006860-a3b8hyyr	211	10	to	to	IN
cord-006860-a3b8hyyr	211	11	values	value	NNS
cord-006860-a3b8hyyr	212	1	>	>	XX
cord-006860-a3b8hyyr	212	2	100	100	CD
cord-006860-a3b8hyyr	212	3	see	see	VB
cord-006860-a3b8hyyr	212	4	..	..	.
cord-006860-a3b8hyyr	213	1	During	during	IN
cord-006860-a3b8hyyr	213	2	the	the	DT
cord-006860-a3b8hyyr	213	3	study	study	NN
cord-006860-a3b8hyyr	213	4	4	4	CD
cord-006860-a3b8hyyr	213	5	patients	patient	NNS
cord-006860-a3b8hyyr	213	6	with	with	IN
cord-006860-a3b8hyyr	213	7	anti	anti	JJ
cord-006860-a3b8hyyr	213	8	-	-	JJ
cord-006860-a3b8hyyr	213	9	hirudin	hirudin	JJ
cord-006860-a3b8hyyr	213	10	antibodies	antibody	NNS
cord-006860-a3b8hyyr	213	11	had	have	VBD
cord-006860-a3b8hyyr	213	12	to	to	TO
cord-006860-a3b8hyyr	213	13	be	be	VB
cord-006860-a3b8hyyr	213	14	reexposed	reexpose	VBN
cord-006860-a3b8hyyr	213	15	to	to	IN
cord-006860-a3b8hyyr	213	16	a	a	DT
cord-006860-a3b8hyyr	213	17	second	second	JJ
cord-006860-a3b8hyyr	213	18	course	course	NN
cord-006860-a3b8hyyr	213	19	of	of	IN
cord-006860-a3b8hyyr	213	20	r	r	NN
cord-006860-a3b8hyyr	213	21	-	-	:
cord-006860-a3b8hyyr	213	22	hirudin	hirudin	NN
cord-006860-a3b8hyyr	213	23	for	for	IN
cord-006860-a3b8hyyr	213	24	parenteral	parenteral	JJ
cord-006860-a3b8hyyr	213	25	anticoaguhtion	anticoaguhtion	NN
cord-006860-a3b8hyyr	214	1	None	none	NN
cord-006860-a3b8hyyr	214	2	of	of	IN
cord-006860-a3b8hyyr	214	3	these	these	DT
cord-006860-a3b8hyyr	214	4	patients	patient	NNS
cord-006860-a3b8hyyr	214	5	developed	develop	VBD
cord-006860-a3b8hyyr	214	6	any	any	DT
cord-006860-a3b8hyyr	214	7	allergic	allergic	JJ
cord-006860-a3b8hyyr	214	8	reaction	reaction	NN
cord-006860-a3b8hyyr	214	9	.	.	.
cord-006860-a3b8hyyr	215	1	In	in	IN
cord-006860-a3b8hyyr	215	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	215	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	215	4	found	find	VBD
cord-006860-a3b8hyyr	215	5	a	a	DT
cord-006860-a3b8hyyr	215	6	high	high	JJ
cord-006860-a3b8hyyr	215	7	proportion	proportion	NN
cord-006860-a3b8hyyr	215	8	of	of	IN
cord-006860-a3b8hyyr	215	9	anti	anti	JJ
cord-006860-a3b8hyyr	215	10	-	-	JJ
cord-006860-a3b8hyyr	215	11	hirudin	hirudin	JJ
cord-006860-a3b8hyyr	215	12	antibodies	antibody	NNS
cord-006860-a3b8hyyr	215	13	in	in	IN
cord-006860-a3b8hyyr	215	14	HATpatients	hatpatient	NNS
cord-006860-a3b8hyyr	215	15	treated	treat	VBN
cord-006860-a3b8hyyr	215	16	with	with	IN
cord-006860-a3b8hyyr	215	17	r	r	NN
cord-006860-a3b8hyyr	215	18	-	-	:
cord-006860-a3b8hyyr	215	19	hirudin	hirudin	JJ
cord-006860-a3b8hyyr	215	20	for	for	IN
cord-006860-a3b8hyyr	215	21	more	more	JJR
cord-006860-a3b8hyyr	215	22	than	than	IN
cord-006860-a3b8hyyr	215	23	7	7	CD
cord-006860-a3b8hyyr	215	24	days	day	NNS
cord-006860-a3b8hyyr	215	25	.	.	.
cord-006860-a3b8hyyr	216	1	These	these	DT
cord-006860-a3b8hyyr	216	2	antibodies	antibody	NNS
cord-006860-a3b8hyyr	216	3	seem	seem	VBP
cord-006860-a3b8hyyr	216	4	to	to	TO
cord-006860-a3b8hyyr	216	5	have	have	VB
cord-006860-a3b8hyyr	216	6	minor	minor	JJ
cord-006860-a3b8hyyr	216	7	clinical	clinical	JJ
cord-006860-a3b8hyyr	216	8	relevance	relevance	NN
cord-006860-a3b8hyyr	216	9	in	in	IN
cord-006860-a3b8hyyr	216	10	regard	regard	NN
cord-006860-a3b8hyyr	216	11	to	to	IN
cord-006860-a3b8hyyr	216	12	allergic	allergic	JJ
cord-006860-a3b8hyyr	216	13	reactions	reaction	NNS
cord-006860-a3b8hyyr	216	14	.	.	.
cord-006860-a3b8hyyr	217	1	However	however	RB
cord-006860-a3b8hyyr	217	2	,	,	,
cord-006860-a3b8hyyr	217	3	one	one	PRP
cord-006860-a3b8hyyr	217	4	has	have	VBZ
cord-006860-a3b8hyyr	217	5	to	to	TO
cord-006860-a3b8hyyr	217	6	consider	consider	VB
cord-006860-a3b8hyyr	217	7	that	that	IN
cord-006860-a3b8hyyr	217	8	these	these	DT
cord-006860-a3b8hyyr	217	9	antibodies	antibody	NNS
cord-006860-a3b8hyyr	217	10	may	may	MD
cord-006860-a3b8hyyr	217	11	influence	influence	VB
cord-006860-a3b8hyyr	217	12	the	the	DT
cord-006860-a3b8hyyr	217	13	pharmacokinetics	pharmacokinetic	NNS
cord-006860-a3b8hyyr	217	14	of	of	IN
cord-006860-a3b8hyyr	217	15	rhimdin	rhimdin	NNP
cord-006860-a3b8hyyr	217	16	and	and	CC
cord-006860-a3b8hyyr	217	17	thereby	thereby	RB
cord-006860-a3b8hyyr	217	18	enhance	enhance	VB
cord-006860-a3b8hyyr	217	19	its	-PRON-	PRP$
cord-006860-a3b8hyyr	217	20	antieoagulatory	antieoagulatory	NN
cord-006860-a3b8hyyr	217	21	potency	potency	NN
cord-006860-a3b8hyyr	217	22	.	.	.
cord-006860-a3b8hyyr	218	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	218	2	,	,	,
cord-006860-a3b8hyyr	218	3	aPTT	aptt	PRP
cord-006860-a3b8hyyr	218	4	must	must	MD
cord-006860-a3b8hyyr	218	5	be	be	VB
cord-006860-a3b8hyyr	218	6	monitored	monitor	VBN
cord-006860-a3b8hyyr	218	7	closely	closely	RB
cord-006860-a3b8hyyr	218	8	in	in	IN
cord-006860-a3b8hyyr	218	9	patients	patient	NNS
cord-006860-a3b8hyyr	218	10	receiying	receiying	NNP
cord-006860-a3b8hyyr	218	11	r	r	NN
cord-006860-a3b8hyyr	218	12	-	-	:
cord-006860-a3b8hyyr	218	13	hirudin	hirudin	RB
cord-006860-a3b8hyyr	218	14	for	for	IN
cord-006860-a3b8hyyr	218	15	more	more	JJR
cord-006860-a3b8hyyr	218	16	than	than	IN
cord-006860-a3b8hyyr	218	17	5	5	CD
cord-006860-a3b8hyyr	218	18	days	day	NNS
cord-006860-a3b8hyyr	219	1	A	a	DT
cord-006860-a3b8hyyr	219	2	major	major	JJ
cord-006860-a3b8hyyr	219	3	concern	concern	NN
cord-006860-a3b8hyyr	219	4	in	in	IN
cord-006860-a3b8hyyr	219	5	the	the	DT
cord-006860-a3b8hyyr	219	6	use	use	NN
cord-006860-a3b8hyyr	219	7	of	of	IN
cord-006860-a3b8hyyr	219	8	hirndin	hirndin	NNP
cord-006860-a3b8hyyr	219	9	,	,	,
cord-006860-a3b8hyyr	219	10	the	the	DT
cord-006860-a3b8hyyr	219	11	most	most	RBS
cord-006860-a3b8hyyr	219	12	potent	potent	JJ
cord-006860-a3b8hyyr	219	13	and	and	CC
cord-006860-a3b8hyyr	219	14	specific	specific	JJ
cord-006860-a3b8hyyr	219	15	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	219	16	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	219	17	,	,	,
cord-006860-a3b8hyyr	219	18	is	be	VBZ
cord-006860-a3b8hyyr	219	19	the	the	DT
cord-006860-a3b8hyyr	219	20	risk	risk	NN
cord-006860-a3b8hyyr	219	21	of	of	IN
cord-006860-a3b8hyyr	219	22	bleeding	bleed	VBG
cord-006860-a3b8hyyr	219	23	associated	associate	VBN
cord-006860-a3b8hyyr	219	24	with	with	IN
cord-006860-a3b8hyyr	219	25	the	the	DT
cord-006860-a3b8hyyr	219	26	potential	potential	JJ
cord-006860-a3b8hyyr	219	27	effect	effect	NN
cord-006860-a3b8hyyr	219	28	of	of	IN
cord-006860-a3b8hyyr	219	29	this	this	DT
cord-006860-a3b8hyyr	219	30	drug	drug	NN
cord-006860-a3b8hyyr	219	31	on	on	IN
cord-006860-a3b8hyyr	219	32	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	219	33	,	,	,
cord-006860-a3b8hyyr	219	34	particularly	particularly	RB
cord-006860-a3b8hyyr	219	35	when	when	WRB
cord-006860-a3b8hyyr	219	36	the	the	DT
cord-006860-a3b8hyyr	219	37	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	219	38	therapy	therapy	NN
cord-006860-a3b8hyyr	219	39	is	be	VBZ
cord-006860-a3b8hyyr	219	40	combined	combine	VBN
cord-006860-a3b8hyyr	219	41	with	with	IN
cord-006860-a3b8hyyr	219	42	invasivo	invasivo	NNP
cord-006860-a3b8hyyr	219	43	procedures	procedure	NNS
cord-006860-a3b8hyyr	219	44	,	,	,
cord-006860-a3b8hyyr	219	45	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	219	46	treatment	treatment	NN
cord-006860-a3b8hyyr	219	47	,	,	,
cord-006860-a3b8hyyr	219	48	or	or	CC
cord-006860-a3b8hyyr	219	49	patient	patient	NN
cord-006860-a3b8hyyr	219	50	's	's	POS
cord-006860-a3b8hyyr	219	51	predisposition	predisposition	NN
cord-006860-a3b8hyyr	219	52	to	to	IN
cord-006860-a3b8hyyr	219	53	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	219	54	bleeding	bleeding	NN
cord-006860-a3b8hyyr	219	55	.	.	.
cord-006860-a3b8hyyr	220	1	Thus	thus	RB
cord-006860-a3b8hyyr	220	2	,	,	,
cord-006860-a3b8hyyr	220	3	availability	availability	NN
cord-006860-a3b8hyyr	220	4	of	of	IN
cord-006860-a3b8hyyr	220	5	an	an	DT
cord-006860-a3b8hyyr	220	6	antagonist	antagonist	NN
cord-006860-a3b8hyyr	220	7	to	to	IN
cord-006860-a3b8hyyr	220	8	hirudin	hirudin	NN
cord-006860-a3b8hyyr	220	9	would	would	MD
cord-006860-a3b8hyyr	220	10	be	be	VB
cord-006860-a3b8hyyr	220	11	essential	essential	JJ
cord-006860-a3b8hyyr	220	12	for	for	IN
cord-006860-a3b8hyyr	220	13	instant	instant	JJ
cord-006860-a3b8hyyr	220	14	neutralization	neutralization	NN
cord-006860-a3b8hyyr	220	15	of	of	IN
cord-006860-a3b8hyyr	220	16	the	the	DT
cord-006860-a3b8hyyr	220	17	antithrombotie	antithrombotie	NN
cord-006860-a3b8hyyr	220	18	action	action	NN
cord-006860-a3b8hyyr	220	19	.	.	.
cord-006860-a3b8hyyr	221	1	However	however	RB
cord-006860-a3b8hyyr	221	2	,	,	,
cord-006860-a3b8hyyr	221	3	thueh	thueh	NNP
cord-006860-a3b8hyyr	221	4	a	a	DT
cord-006860-a3b8hyyr	221	5	hirudin	hirudin	NN
cord-006860-a3b8hyyr	221	6	antagonist	antagonist	NN
cord-006860-a3b8hyyr	221	7	is	be	VBZ
cord-006860-a3b8hyyr	221	8	unknown	unknown	JJ
cord-006860-a3b8hyyr	221	9	in	in	IN
cord-006860-a3b8hyyr	221	10	nature	nature	NN
cord-006860-a3b8hyyr	221	11	.	.	.
cord-006860-a3b8hyyr	222	1	To	to	TO
cord-006860-a3b8hyyr	222	2	prepare	prepare	VB
cord-006860-a3b8hyyr	222	3	an	an	DT
cord-006860-a3b8hyyr	222	4	antagonist	antagonist	NN
cord-006860-a3b8hyyr	222	5	to	to	IN
cord-006860-a3b8hyyr	222	6	hirudin	hirudin	NN
cord-006860-a3b8hyyr	222	7	,	,	,
cord-006860-a3b8hyyr	222	8	a	a	DT
cord-006860-a3b8hyyr	222	9	mutant	mutant	JJ
cord-006860-a3b8hyyr	222	10	derivative	derivative	NN
cord-006860-a3b8hyyr	222	11	of	of	IN
cord-006860-a3b8hyyr	222	12	human	human	JJ
cord-006860-a3b8hyyr	222	13	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	222	14	,	,	,
cord-006860-a3b8hyyr	222	15	in	in	IN
cord-006860-a3b8hyyr	222	16	which	which	WDT
cord-006860-a3b8hyyr	222	17	active	active	JJ
cord-006860-a3b8hyyr	222	18	site	site	NN
cord-006860-a3b8hyyr	222	19	aspartate	aspartate	NN
cord-006860-a3b8hyyr	222	20	at	at	IN
cord-006860-a3b8hyyr	222	21	position	position	NN
cord-006860-a3b8hyyr	222	22	419	419	CD
cord-006860-a3b8hyyr	222	23	is	be	VBZ
cord-006860-a3b8hyyr	222	24	replaced	replace	VBN
cord-006860-a3b8hyyr	222	25	by	by	IN
cord-006860-a3b8hyyr	222	26	an	an	DT
cord-006860-a3b8hyyr	222	27	asparagine	asparagine	NN
cord-006860-a3b8hyyr	222	28	,	,	,
cord-006860-a3b8hyyr	222	29	has	have	VBZ
cord-006860-a3b8hyyr	222	30	been	be	VBN
cord-006860-a3b8hyyr	222	31	designed	design	VBN
cord-006860-a3b8hyyr	222	32	,	,	,
cord-006860-a3b8hyyr	222	33	expressed	express	VBN
cord-006860-a3b8hyyr	222	34	in	in	IN
cord-006860-a3b8hyyr	222	35	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	222	36	chinese	chinese	JJ
cord-006860-a3b8hyyr	222	37	hamster	hamster	NN
cord-006860-a3b8hyyr	222	38	ovary	ovary	NN
cord-006860-a3b8hyyr	222	39	cells	cell	NNS
cord-006860-a3b8hyyr	222	40	,	,	,
cord-006860-a3b8hyyr	222	41	and	and	CC
cord-006860-a3b8hyyr	222	42	purified	purify	VBN
cord-006860-a3b8hyyr	222	43	to	to	IN
cord-006860-a3b8hyyr	222	44	homogeneity	homogeneity	NN
cord-006860-a3b8hyyr	222	45	.	.	.
cord-006860-a3b8hyyr	223	1	D419N	D419N	NNP
cord-006860-a3b8hyyr	223	2	-	-	HYPH
cord-006860-a3b8hyyr	223	3	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	223	4	was	be	VBD
cord-006860-a3b8hyyr	223	5	converted	convert	VBN
cord-006860-a3b8hyyr	223	6	to	to	IN
cord-006860-a3b8hyyr	223	7	the	the	DT
cord-006860-a3b8hyyr	223	8	related	related	JJ
cord-006860-a3b8hyyr	223	9	molecules	molecule	NNS
cord-006860-a3b8hyyr	223	10	D419N	D419N	NNP
cord-006860-a3b8hyyr	223	11	-	-	HYPH
cord-006860-a3b8hyyr	223	12	meizothrombin	meizothrombin	NNP
cord-006860-a3b8hyyr	223	13	and	and	CC
cord-006860-a3b8hyyr	223	14	D419N	D419N	NNP
cord-006860-a3b8hyyr	223	15	-	-	:
cord-006860-a3b8hyyr	223	16	thrombin	thrombin	NN
cord-006860-a3b8hyyr	223	17	by	by	IN
cord-006860-a3b8hyyr	223	18	limited	limited	JJ
cord-006860-a3b8hyyr	223	19	proteolysis	proteolysis	NN
cord-006860-a3b8hyyr	223	20	by	by	IN
cord-006860-a3b8hyyr	223	21	E.	E.	NNP
cord-006860-a3b8hyyr	223	22	carinatue	carinatue	NN
cord-006860-a3b8hyyr	223	23	venom	venom	NN
cord-006860-a3b8hyyr	223	24	and	and	CC
cord-006860-a3b8hyyr	223	25	O.	O.	NNP
cord-006860-a3b8hyyr	223	26	scvutellatus	scvutellatus	NN
cord-006860-a3b8hyyr	223	27	venom	venom	NN
cord-006860-a3b8hyyr	223	28	,	,	,
cord-006860-a3b8hyyr	223	29	respectively	respectively	RB
cord-006860-a3b8hyyr	223	30	.	.	.
cord-006860-a3b8hyyr	224	1	Both	both	DT
cord-006860-a3b8hyyr	224	2	D419N	D419N	NNP
cord-006860-a3b8hyyr	224	3	-	-	HYPH
cord-006860-a3b8hyyr	224	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	224	5	and	and	CC
cord-006860-a3b8hyyr	224	6	D419Nmeizothrombin	D419Nmeizothrombin	NNP
cord-006860-a3b8hyyr	224	7	exhibited	exhibit	VBN
cord-006860-a3b8hyyr	225	1	no	no	DT
cord-006860-a3b8hyyr	225	2	thrombin	thrombin	NN
cord-006860-a3b8hyyr	225	3	activity	activity	NN
cord-006860-a3b8hyyr	225	4	and	and	CC
cord-006860-a3b8hyyr	225	5	titration	titration	NN
cord-006860-a3b8hyyr	225	6	resulted	result	VBD
cord-006860-a3b8hyyr	225	7	no	no	DT
cord-006860-a3b8hyyr	225	8	detection	detection	NN
cord-006860-a3b8hyyr	225	9	of	of	IN
cord-006860-a3b8hyyr	225	10	the	the	DT
cord-006860-a3b8hyyr	225	11	active	active	JJ
cord-006860-a3b8hyyr	225	12	site	site	NN
cord-006860-a3b8hyyr	225	13	.	.	.
cord-006860-a3b8hyyr	226	1	However	however	RB
cord-006860-a3b8hyyr	226	2	,	,	,
cord-006860-a3b8hyyr	226	3	binding	bind	VBG
cord-006860-a3b8hyyr	226	4	to	to	IN
cord-006860-a3b8hyyr	226	5	solid	solid	JJ
cord-006860-a3b8hyyr	226	6	phase	phase	NN
cord-006860-a3b8hyyr	226	7	immobilized	immobilize	VBN
cord-006860-a3b8hyyr	226	8	hirudin	hirudin	NN
cord-006860-a3b8hyyr	226	9	and	and	CC
cord-006860-a3b8hyyr	226	10	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	226	11	studies	study	NNS
cord-006860-a3b8hyyr	226	12	confirmed	confirm	VBD
cord-006860-a3b8hyyr	226	13	that	that	IN
cord-006860-a3b8hyyr	226	14	the	the	DT
cord-006860-a3b8hyyr	226	15	binding	binding	NN
cord-006860-a3b8hyyr	226	16	to	to	IN
cord-006860-a3b8hyyr	226	17	the	the	DT
cord-006860-a3b8hyyr	226	18	most	most	RBS
cord-006860-a3b8hyyr	226	19	specific	specific	JJ
cord-006860-a3b8hyyr	226	20	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	226	21	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	226	22	,	,	,
cord-006860-a3b8hyyr	226	23	hirudin	hirudin	NN
cord-006860-a3b8hyyr	226	24	,	,	,
cord-006860-a3b8hyyr	226	25	was	be	VBD
cord-006860-a3b8hyyr	226	26	conserved	conserve	VBN
cord-006860-a3b8hyyr	226	27	in	in	IN
cord-006860-a3b8hyyr	226	28	both	both	DT
cord-006860-a3b8hyyr	226	29	proteins	protein	NNS
cord-006860-a3b8hyyr	226	30	,	,	,
cord-006860-a3b8hyyr	226	31	hi	hi	UH
cord-006860-a3b8hyyr	226	32	vitro	vitro	FW
cord-006860-a3b8hyyr	226	33	examinations	examination	NNS
cord-006860-a3b8hyyr	226	34	showed	show	VBD
cord-006860-a3b8hyyr	226	35	that	that	IN
cord-006860-a3b8hyyr	226	36	D419N	D419N	NNP
cord-006860-a3b8hyyr	226	37	-	-	HYPH
cord-006860-a3b8hyyr	226	38	thrombin	thrombin	NN
cord-006860-a3b8hyyr	226	39	and	and	CC
cord-006860-a3b8hyyr	226	40	D419Nmeizothrombin	d419nmeizothrombin	IN
cord-006860-a3b8hyyr	226	41	bind	bind	VB
cord-006860-a3b8hyyr	226	42	to	to	IN
cord-006860-a3b8hyyr	226	43	immobilized	immobilized	JJ
cord-006860-a3b8hyyr	226	44	hirudin	hirudin	NN
cord-006860-a3b8hyyr	226	45	,	,	,
cord-006860-a3b8hyyr	226	46	neutralize	neutralize	VB
cord-006860-a3b8hyyr	226	47	hirudin	hirudin	NN
cord-006860-a3b8hyyr	226	48	as	as	RB
cord-006860-a3b8hyyr	226	49	well	well	RB
cord-006860-a3b8hyyr	226	50	as	as	IN
cord-006860-a3b8hyyr	226	51	in	in	IN
cord-006860-a3b8hyyr	226	52	the	the	DT
cord-006860-a3b8hyyr	226	53	purified	purify	VBN
cord-006860-a3b8hyyr	226	54	system	system	NN
cord-006860-a3b8hyyr	226	55	and	and	CC
cord-006860-a3b8hyyr	226	56	in	in	IN
cord-006860-a3b8hyyr	226	57	human	human	JJ
cord-006860-a3b8hyyr	226	58	blood	blood	NN
cord-006860-a3b8hyyr	226	59	plasma	plasma	NN
cord-006860-a3b8hyyr	226	60	and	and	CC
cord-006860-a3b8hyyr	226	61	re	re	NN
cord-006860-a3b8hyyr	226	62	-	-	NN
cord-006860-a3b8hyyr	226	63	activate	activate	VB
cord-006860-a3b8hyyr	226	64	the	the	DT
cord-006860-a3b8hyyr	226	65	thrombin	thrombin	NN
cord-006860-a3b8hyyr	226	66	-	-	HYPH
cord-006860-a3b8hyyr	226	67	hirudin	hirudin	NN
cord-006860-a3b8hyyr	226	68	complex	complex	NN
cord-006860-a3b8hyyr	226	69	.	.	.
cord-006860-a3b8hyyr	227	1	Animal	animal	NN
cord-006860-a3b8hyyr	227	2	model	model	NN
cord-006860-a3b8hyyr	227	3	studies	study	NNS
cord-006860-a3b8hyyr	227	4	confirmed	confirm	VBD
cord-006860-a3b8hyyr	227	5	that	that	IN
cord-006860-a3b8hyyr	227	6	D419Nthrombin	D419Nthrombin	NNP
cord-006860-a3b8hyyr	228	1	and	and	CC
cord-006860-a3b8hyyr	228	2	D419N	D419N	NNP
cord-006860-a3b8hyyr	228	3	-	-	HYPH
cord-006860-a3b8hyyr	228	4	meizothromi	meizothromi	NNP
cord-006860-a3b8hyyr	228	5	.	.	.
cord-006860-a3b8hyyr	229	1	,	,	,
cord-006860-a3b8hyyr	229	2	in	in	IN
cord-006860-a3b8hyyr	229	3	act	act	NN
cord-006860-a3b8hyyr	229	4	as	as	IN
cord-006860-a3b8hyyr	229	5	hirudin	hirudin	NN
cord-006860-a3b8hyyr	229	6	antagonist	antagonist	NN
cord-006860-a3b8hyyr	229	7	in	in	IN
cord-006860-a3b8hyyr	229	8	blood	blood	NN
cord-006860-a3b8hyyr	229	9	cireulatlon	cireulatlon	NN
cord-006860-a3b8hyyr	229	10	without	without	IN
cord-006860-a3b8hyyr	229	11	detectable	detectable	JJ
cord-006860-a3b8hyyr	229	12	effects	effect	NNS
cord-006860-a3b8hyyr	229	13	on	on	IN
cord-006860-a3b8hyyr	229	14	the	the	DT
cord-006860-a3b8hyyr	229	15	coagulation	coagulation	NN
cord-006860-a3b8hyyr	229	16	system	system	NN
cord-006860-a3b8hyyr	229	17	.	.	.
cord-006860-a3b8hyyr	230	1	While	while	IN
cord-006860-a3b8hyyr	230	2	i.v	i.v	NNP
cord-006860-a3b8hyyr	230	3	.	.	.
cord-006860-a3b8hyyr	230	4	injections	injection	NNS
cord-006860-a3b8hyyr	230	5	of	of	IN
cord-006860-a3b8hyyr	230	6	hirudin	hirudin	NN
cord-006860-a3b8hyyr	230	7	in	in	IN
cord-006860-a3b8hyyr	230	8	mice	mouse	NNS
cord-006860-a3b8hyyr	230	9	resulted	result	VBD
cord-006860-a3b8hyyr	230	10	in	in	IN
cord-006860-a3b8hyyr	230	11	an	an	DT
cord-006860-a3b8hyyr	230	12	increase	increase	NN
cord-006860-a3b8hyyr	230	13	in	in	IN
cord-006860-a3b8hyyr	230	14	partial	partial	JJ
cord-006860-a3b8hyyr	230	15	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	230	16	time	time	NN
cord-006860-a3b8hyyr	230	17	,	,	,
cord-006860-a3b8hyyr	230	18	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	230	19	time	time	NN
cord-006860-a3b8hyyr	230	20	and	and	CC
cord-006860-a3b8hyyr	230	21	anti	anti	JJ
cord-006860-a3b8hyyr	230	22	-	-	JJ
cord-006860-a3b8hyyr	230	23	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	230	24	potential	potential	NN
cord-006860-a3b8hyyr	230	25	,	,	,
cord-006860-a3b8hyyr	230	26	additional	additional	JJ
cord-006860-a3b8hyyr	230	27	injections	injection	NNS
cord-006860-a3b8hyyr	230	28	of	of	IN
cord-006860-a3b8hyyr	230	29	D419N	D419N	NNP
cord-006860-a3b8hyyr	230	30	-	-	:
cord-006860-a3b8hyyr	230	31	thrombin	thrombin	NN
cord-006860-a3b8hyyr	230	32	and	and	CC
cord-006860-a3b8hyyr	230	33	D419N	D419N	NNP
cord-006860-a3b8hyyr	230	34	-	-	HYPH
cord-006860-a3b8hyyr	230	35	meizothrombin	meizothrombin	NNP
cord-006860-a3b8hyyr	230	36	resulted	result	VBD
cord-006860-a3b8hyyr	230	37	in	in	IN
cord-006860-a3b8hyyr	230	38	a	a	DT
cord-006860-a3b8hyyr	230	39	normalization	normalization	NN
cord-006860-a3b8hyyr	230	40	of	of	IN
cord-006860-a3b8hyyr	230	41	these	these	DT
cord-006860-a3b8hyyr	230	42	coagulation	coagulation	NN
cord-006860-a3b8hyyr	230	43	parameters	parameter	NNS
cord-006860-a3b8hyyr	230	44	.	.	.
cord-006860-a3b8hyyr	231	1	Elevation	elevation	NN
cord-006860-a3b8hyyr	231	2	of	of	IN
cord-006860-a3b8hyyr	231	3	plasma	plasma	NN
cord-006860-a3b8hyyr	231	4	homocysteine	homocysteine	NN
cord-006860-a3b8hyyr	231	5	is	be	VBZ
cord-006860-a3b8hyyr	231	6	a	a	DT
cord-006860-a3b8hyyr	231	7	hereditary	hereditary	JJ
cord-006860-a3b8hyyr	231	8	disorder	disorder	NN
cord-006860-a3b8hyyr	231	9	of	of	IN
cord-006860-a3b8hyyr	231	10	methionine	methionine	NN
cord-006860-a3b8hyyr	231	11	metabolism	metabolism	NN
cord-006860-a3b8hyyr	231	12	associated	associate	VBN
cord-006860-a3b8hyyr	231	13	with	with	IN
cord-006860-a3b8hyyr	231	14	a	a	DT
cord-006860-a3b8hyyr	231	15	high	high	JJ
cord-006860-a3b8hyyr	231	16	risk	risk	NN
cord-006860-a3b8hyyr	231	17	of	of	IN
cord-006860-a3b8hyyr	231	18	arterial	arterial	JJ
cord-006860-a3b8hyyr	231	19	vascular	vascular	JJ
cord-006860-a3b8hyyr	231	20	disease	disease	NN
cord-006860-a3b8hyyr	231	21	.	.	.
cord-006860-a3b8hyyr	232	1	However	however	RB
cord-006860-a3b8hyyr	232	2	,	,	,
cord-006860-a3b8hyyr	232	3	as	as	IN
cord-006860-a3b8hyyr	232	4	yet	yet	CC
cord-006860-a3b8hyyr	232	5	relatively	relatively	RB
cord-006860-a3b8hyyr	232	6	little	little	JJ
cord-006860-a3b8hyyr	232	7	attention	attention	NN
cord-006860-a3b8hyyr	232	8	has	have	VBZ
cord-006860-a3b8hyyr	232	9	been	be	VBN
cord-006860-a3b8hyyr	232	10	directed	direct	VBN
cord-006860-a3b8hyyr	232	11	towards	towards	IN
cord-006860-a3b8hyyr	232	12	the	the	DT
cord-006860-a3b8hyyr	232	13	association	association	NN
cord-006860-a3b8hyyr	232	14	between	between	IN
cord-006860-a3b8hyyr	232	15	hyperhomocysteinemia	hyperhomocysteinemia	NNP
cord-006860-a3b8hyyr	232	16	and	and	CC
cord-006860-a3b8hyyr	232	17	juvenile	juvenile	JJ
cord-006860-a3b8hyyr	232	18	venous	venous	JJ
cord-006860-a3b8hyyr	232	19	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	232	20	(	(	-LRB-
cord-006860-a3b8hyyr	232	21	VTE	VTE	NNP
cord-006860-a3b8hyyr	232	22	)	)	-RRB-
cord-006860-a3b8hyyr	232	23	.	.	.
cord-006860-a3b8hyyr	233	1	Consequently	consequently	RB
cord-006860-a3b8hyyr	233	2	the	the	DT
cord-006860-a3b8hyyr	233	3	aim	aim	NN
cord-006860-a3b8hyyr	233	4	of	of	IN
cord-006860-a3b8hyyr	233	5	our	-PRON-	PRP$
cord-006860-a3b8hyyr	233	6	study	study	NN
cord-006860-a3b8hyyr	233	7	was	be	VBD
cord-006860-a3b8hyyr	233	8	to	to	TO
cord-006860-a3b8hyyr	233	9	evaluate	evaluate	VB
cord-006860-a3b8hyyr	233	10	the	the	DT
cord-006860-a3b8hyyr	233	11	prevalence	prevalence	NN
cord-006860-a3b8hyyr	233	12	of	of	IN
cord-006860-a3b8hyyr	233	13	hyperhomocysteinemia	hyperhomocysteinemia	NNP
cord-006860-a3b8hyyr	233	14	(	(	-LRB-
cord-006860-a3b8hyyr	233	15	hyper	hyper	NNP
cord-006860-a3b8hyyr	233	16	-	-	JJ
cord-006860-a3b8hyyr	233	17	HCYS	hcys	JJ
cord-006860-a3b8hyyr	233	18	)	)	-RRB-
cord-006860-a3b8hyyr	233	19	and	and	CC
cord-006860-a3b8hyyr	233	20	juvenile	juvenile	JJ
cord-006860-a3b8hyyr	233	21	VTE	VTE	NNP
cord-006860-a3b8hyyr	233	22	.	.	.
cord-006860-a3b8hyyr	234	1	Patients	patient	NNS
cord-006860-a3b8hyyr	234	2	:	:	:
cord-006860-a3b8hyyr	234	3	85	85	CD
cord-006860-a3b8hyyr	234	4	patients	patient	NNS
cord-006860-a3b8hyyr	234	5	(	(	-LRB-
cord-006860-a3b8hyyr	234	6	29	29	CD
cord-006860-a3b8hyyr	234	7	men	man	NNS
cord-006860-a3b8hyyr	234	8	,	,	,
cord-006860-a3b8hyyr	234	9	median	median	NN
cord-006860-a3b8hyyr	234	10	age	age	NN
cord-006860-a3b8hyyr	234	11	42	42	CD
cord-006860-a3b8hyyr	234	12	ys	y	NNS
cord-006860-a3b8hyyr	234	13	;	;	:
cord-006860-a3b8hyyr	234	14	56	56	CD
cord-006860-a3b8hyyr	234	15	women	woman	NNS
cord-006860-a3b8hyyr	234	16	,	,	,
cord-006860-a3b8hyyr	234	17	median	median	NN
cord-006860-a3b8hyyr	234	18	age	age	NN
cord-006860-a3b8hyyr	234	19	35	35	CD
cord-006860-a3b8hyyr	234	20	ys	y	NNS
cord-006860-a3b8hyyr	234	21	)	)	-RRB-
cord-006860-a3b8hyyr	234	22	who	who	WP
cord-006860-a3b8hyyr	234	23	had	have	VBD
cord-006860-a3b8hyyr	234	24	at	at	RB
cord-006860-a3b8hyyr	234	25	least	least	RBS
cord-006860-a3b8hyyr	234	26	one	one	CD
cord-006860-a3b8hyyr	234	27	verified	verify	VBN
cord-006860-a3b8hyyr	234	28	episode	episode	NN
cord-006860-a3b8hyyr	234	29	of	of	IN
cord-006860-a3b8hyyr	234	30	VTE	VTE	NNP
cord-006860-a3b8hyyr	234	31	before	before	IN
cord-006860-a3b8hyyr	234	32	the	the	DT
cord-006860-a3b8hyyr	234	33	age	age	NN
cord-006860-a3b8hyyr	234	34	of	of	IN
cord-006860-a3b8hyyr	234	35	45	45	CD
cord-006860-a3b8hyyr	234	36	ys	y	NNS
cord-006860-a3b8hyyr	234	37	were	be	VBD
cord-006860-a3b8hyyr	234	38	investigated	investigate	VBN
cord-006860-a3b8hyyr	234	39	in	in	IN
cord-006860-a3b8hyyr	234	40	regard	regard	NN
cord-006860-a3b8hyyr	234	41	to	to	IN
cord-006860-a3b8hyyr	234	42	their	-PRON-	PRP$
cord-006860-a3b8hyyr	234	43	total	total	JJ
cord-006860-a3b8hyyr	234	44	plasma	plasma	NN
cord-006860-a3b8hyyr	234	45	HCYS	HCYS	NNP
cord-006860-a3b8hyyr	234	46	levels	level	NNS
cord-006860-a3b8hyyr	234	47	.	.	.
cord-006860-a3b8hyyr	235	1	None	none	NN
cord-006860-a3b8hyyr	235	2	of	of	IN
cord-006860-a3b8hyyr	235	3	the	the	DT
cord-006860-a3b8hyyr	235	4	patients	patient	NNS
cord-006860-a3b8hyyr	235	5	had	have	VBD
cord-006860-a3b8hyyr	235	6	renal	renal	JJ
cord-006860-a3b8hyyr	235	7	or	or	CC
cord-006860-a3b8hyyr	235	8	liver	liver	JJ
cord-006860-a3b8hyyr	235	9	dysfunction	dysfunction	NN
cord-006860-a3b8hyyr	235	10	or	or	CC
cord-006860-a3b8hyyr	235	11	evidence	evidence	NN
cord-006860-a3b8hyyr	235	12	of	of	IN
cord-006860-a3b8hyyr	235	13	any	any	DT
cord-006860-a3b8hyyr	235	14	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	235	15	or	or	CC
cord-006860-a3b8hyyr	235	16	neoplastic	neoplastic	JJ
cord-006860-a3b8hyyr	235	17	disease	disease	NN
cord-006860-a3b8hyyr	235	18	.	.	.
cord-006860-a3b8hyyr	236	1	Methods	method	NNS
cord-006860-a3b8hyyr	236	2	:	:	:
cord-006860-a3b8hyyr	236	3	Plasma	plasma	NN
cord-006860-a3b8hyyr	236	4	total	total	JJ
cord-006860-a3b8hyyr	236	5	homocysteine	homocysteine	NN
cord-006860-a3b8hyyr	236	6	levels	level	NNS
cord-006860-a3b8hyyr	236	7	were	be	VBD
cord-006860-a3b8hyyr	236	8	determined	determine	VBN
cord-006860-a3b8hyyr	236	9	by	by	IN
cord-006860-a3b8hyyr	236	10	HPLC	HPLC	NNP
cord-006860-a3b8hyyr	236	11	with	with	IN
cord-006860-a3b8hyyr	236	12	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	236	13	detection	detection	NN
cord-006860-a3b8hyyr	236	14	.	.	.
cord-006860-a3b8hyyr	237	1	Hyperhomocysteinemia	Hyperhomocysteinemia	NNP
cord-006860-a3b8hyyr	237	2	was	be	VBD
cord-006860-a3b8hyyr	237	3	defined	define	VBN
cord-006860-a3b8hyyr	237	4	as	as	IN
cord-006860-a3b8hyyr	237	5	HCYS	HCYS	NNP
cord-006860-a3b8hyyr	237	6	levels	level	NNS
cord-006860-a3b8hyyr	237	7	exceeding	exceed	VBG
cord-006860-a3b8hyyr	237	8	the	the	DT
cord-006860-a3b8hyyr	237	9	upper	upper	JJ
cord-006860-a3b8hyyr	237	10	limit	limit	NN
cord-006860-a3b8hyyr	237	11	of	of	IN
cord-006860-a3b8hyyr	237	12	the	the	DT
cord-006860-a3b8hyyr	237	13	normal	normal	JJ
cord-006860-a3b8hyyr	237	14	range	range	NN
cord-006860-a3b8hyyr	237	15	obtained	obtain	VBN
cord-006860-a3b8hyyr	237	16	in	in	IN
cord-006860-a3b8hyyr	237	17	our	-PRON-	PRP$
cord-006860-a3b8hyyr	237	18	laboratory	laboratory	NN
cord-006860-a3b8hyyr	237	19	from	from	IN
cord-006860-a3b8hyyr	237	20	80	80	CD
cord-006860-a3b8hyyr	237	21	healthy	healthy	JJ
cord-006860-a3b8hyyr	237	22	control	control	NN
cord-006860-a3b8hyyr	237	23	subjects	subject	NNS
cord-006860-a3b8hyyr	237	24	(	(	-LRB-
cord-006860-a3b8hyyr	237	25	40	40	CD
cord-006860-a3b8hyyr	237	26	males	male	NNS
cord-006860-a3b8hyyr	237	27	,	,	,
cord-006860-a3b8hyyr	237	28	median	median	JJ
cord-006860-a3b8hyyr	237	29	age	age	NN
cord-006860-a3b8hyyr	237	30	25	25	CD
cord-006860-a3b8hyyr	237	31	ys	ys	NN
cord-006860-a3b8hyyr	237	32	,	,	,
cord-006860-a3b8hyyr	238	1	HCYS	HCYS	NNP
cord-006860-a3b8hyyr	238	2	95	95	CD
cord-006860-a3b8hyyr	238	3	%	%	NN
cord-006860-a3b8hyyr	238	4	CI	ci	NN
cord-006860-a3b8hyyr	238	5	:	:	:
cord-006860-a3b8hyyr	238	6	2.02	2.02	CD
cord-006860-a3b8hyyr	238	7	-	-	SYM
cord-006860-a3b8hyyr	238	8	5.67	5.67	CD
cord-006860-a3b8hyyr	238	9	pmol	pmol	NNP
cord-006860-a3b8hyyr	238	10	/	/	SYM
cord-006860-a3b8hyyr	238	11	l	l	NN
cord-006860-a3b8hyyr	238	12	;	;	:
cord-006860-a3b8hyyr	238	13	40	40	CD
cord-006860-a3b8hyyr	238	14	females	female	NNS
cord-006860-a3b8hyyr	238	15	,	,	,
cord-006860-a3b8hyyr	238	16	median	median	JJ
cord-006860-a3b8hyyr	238	17	age	age	NN
cord-006860-a3b8hyyr	238	18	27.5	27.5	CD
cord-006860-a3b8hyyr	238	19	ys	ys	NN
cord-006860-a3b8hyyr	238	20	,	,	,
cord-006860-a3b8hyyr	238	21	HCYS	HCYS	NNP
cord-006860-a3b8hyyr	238	22	95	95	CD
cord-006860-a3b8hyyr	238	23	%	%	NN
cord-006860-a3b8hyyr	238	24	CI	ci	NN
cord-006860-a3b8hyyr	238	25	:	:	:
cord-006860-a3b8hyyr	238	26	2.99	2.99	CD
cord-006860-a3b8hyyr	238	27	-	-	SYM
cord-006860-a3b8hyyr	238	28	5.40	5.40	CD
cord-006860-a3b8hyyr	238	29	,	,	,
cord-006860-a3b8hyyr	238	30	gruel	gruel	NN
cord-006860-a3b8hyyr	238	31	/	/	SYM
cord-006860-a3b8hyyr	238	32	l	l	NN
cord-006860-a3b8hyyr	238	33	)	)	-RRB-
cord-006860-a3b8hyyr	238	34	.	.	.
cord-006860-a3b8hyyr	239	1	Resuits	resuit	NNS
cord-006860-a3b8hyyr	239	2	:	:	:
cord-006860-a3b8hyyr	240	1	13	13	CD
cord-006860-a3b8hyyr	240	2	out	out	IN
cord-006860-a3b8hyyr	240	3	of	of	IN
cord-006860-a3b8hyyr	240	4	85	85	CD
cord-006860-a3b8hyyr	240	5	patients	patient	NNS
cord-006860-a3b8hyyr	240	6	had	have	VBD
cord-006860-a3b8hyyr	240	7	hyper	hyper	JJ
cord-006860-a3b8hyyr	240	8	-	-	JJ
cord-006860-a3b8hyyr	240	9	HCYS	HCYS	NNP
cord-006860-a3b8hyyr	240	10	,	,	,
cord-006860-a3b8hyyr	240	11	giving	give	VBG
cord-006860-a3b8hyyr	240	12	a	a	DT
cord-006860-a3b8hyyr	240	13	prevalence	prevalence	NN
cord-006860-a3b8hyyr	240	14	of	of	IN
cord-006860-a3b8hyyr	240	15	15.3	15.3	CD
cord-006860-a3b8hyyr	240	16	%	%	NN
cord-006860-a3b8hyyr	240	17	.	.	.
cord-006860-a3b8hyyr	241	1	Of	of	IN
cord-006860-a3b8hyyr	241	2	these	these	DT
cord-006860-a3b8hyyr	241	3	13	13	CD
cord-006860-a3b8hyyr	241	4	patients	patient	NNS
cord-006860-a3b8hyyr	241	5	,	,	,
cord-006860-a3b8hyyr	241	6	9	9	CD
cord-006860-a3b8hyyr	241	7	were	be	VBD
cord-006860-a3b8hyyr	241	8	male	male	JJ
cord-006860-a3b8hyyr	241	9	and	and	CC
cord-006860-a3b8hyyr	241	10	4	4	CD
cord-006860-a3b8hyyr	241	11	female	female	JJ
cord-006860-a3b8hyyr	241	12	,	,	,
cord-006860-a3b8hyyr	241	13	indicating	indicate	VBG
cord-006860-a3b8hyyr	241	14	that	that	IN
cord-006860-a3b8hyyr	241	15	the	the	DT
cord-006860-a3b8hyyr	241	16	relation	relation	NN
cord-006860-a3b8hyyr	241	17	between	between	IN
cord-006860-a3b8hyyr	241	18	elevated	elevated	JJ
cord-006860-a3b8hyyr	241	19	plasma	plasma	NN
cord-006860-a3b8hyyr	241	20	HCYS	HCYS	NNP
cord-006860-a3b8hyyr	241	21	levels	level	NNS
cord-006860-a3b8hyyr	241	22	and	and	CC
cord-006860-a3b8hyyr	241	23	VTE	VTE	NNP
cord-006860-a3b8hyyr	241	24	may	may	MD
cord-006860-a3b8hyyr	241	25	not	not	RB
cord-006860-a3b8hyyr	241	26	be	be	VB
cord-006860-a3b8hyyr	241	27	as	as	RB
cord-006860-a3b8hyyr	241	28	strong	strong	JJ
cord-006860-a3b8hyyr	241	29	in	in	IN
cord-006860-a3b8hyyr	241	30	woman	woman	NN
cord-006860-a3b8hyyr	241	31	as	as	IN
cord-006860-a3b8hyyr	241	32	in	in	IN
cord-006860-a3b8hyyr	241	33	men	man	NNS
cord-006860-a3b8hyyr	241	34	.	.	.
cord-006860-a3b8hyyr	242	1	Discussion	discussion	NN
cord-006860-a3b8hyyr	242	2	:	:	:
cord-006860-a3b8hyyr	243	1	According	accord	VBG
cord-006860-a3b8hyyr	243	2	to	to	IN
cord-006860-a3b8hyyr	243	3	previous	previous	JJ
cord-006860-a3b8hyyr	243	4	reports	report	NNS
cord-006860-a3b8hyyr	243	5	,	,	,
cord-006860-a3b8hyyr	243	6	our	-PRON-	PRP$
cord-006860-a3b8hyyr	243	7	study	study	NN
cord-006860-a3b8hyyr	243	8	shows	show	VBZ
cord-006860-a3b8hyyr	243	9	that	that	IN
cord-006860-a3b8hyyr	243	10	there	there	EX
cord-006860-a3b8hyyr	243	11	is	be	VBZ
cord-006860-a3b8hyyr	243	12	a	a	DT
cord-006860-a3b8hyyr	243	13	high	high	JJ
cord-006860-a3b8hyyr	243	14	prevalence	prevalence	NN
cord-006860-a3b8hyyr	243	15	of	of	IN
cord-006860-a3b8hyyr	243	16	hyper	hyper	JJ
cord-006860-a3b8hyyr	243	17	-	-	JJ
cord-006860-a3b8hyyr	243	18	HCYS	hcys	JJ
cord-006860-a3b8hyyr	243	19	in	in	IN
cord-006860-a3b8hyyr	243	20	patients	patient	NNS
cord-006860-a3b8hyyr	243	21	with	with	IN
cord-006860-a3b8hyyr	243	22	juvenile	juvenile	JJ
cord-006860-a3b8hyyr	243	23	VTE	VTE	NNP
cord-006860-a3b8hyyr	243	24	.	.	.
cord-006860-a3b8hyyr	244	1	However	however	RB
cord-006860-a3b8hyyr	244	2	,	,	,
cord-006860-a3b8hyyr	244	3	the	the	DT
cord-006860-a3b8hyyr	244	4	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	244	5	by	by	IN
cord-006860-a3b8hyyr	244	6	which	which	WDT
cord-006860-a3b8hyyr	244	7	hyper	hyper	NNP
cord-006860-a3b8hyyr	244	8	-	-	JJ
cord-006860-a3b8hyyr	244	9	HCYS	HCYS	NNP
cord-006860-a3b8hyyr	244	10	can	can	MD
cord-006860-a3b8hyyr	244	11	provoke	provoke	VB
cord-006860-a3b8hyyr	244	12	VTE	VTE	NNP
cord-006860-a3b8hyyr	244	13	and	and	CC
cord-006860-a3b8hyyr	244	14	whether	whether	IN
cord-006860-a3b8hyyr	244	15	HCYS	HCYS	NNP
cord-006860-a3b8hyyr	244	16	is	be	VBZ
cord-006860-a3b8hyyr	244	17	an	an	DT
cord-006860-a3b8hyyr	244	18	exclusive	exclusive	JJ
cord-006860-a3b8hyyr	244	19	risk	risk	NN
cord-006860-a3b8hyyr	244	20	factor	factor	NN
cord-006860-a3b8hyyr	244	21	or	or	CC
cord-006860-a3b8hyyr	244	22	if	if	IN
cord-006860-a3b8hyyr	244	23	it	-PRON-	PRP
cord-006860-a3b8hyyr	244	24	contributes	contribute	VBZ
cord-006860-a3b8hyyr	244	25	to	to	IN
cord-006860-a3b8hyyr	244	26	other	other	JJ
cord-006860-a3b8hyyr	244	27	existing	exist	VBG
cord-006860-a3b8hyyr	244	28	predispositions	predisposition	NNS
cord-006860-a3b8hyyr	244	29	,	,	,
cord-006860-a3b8hyyr	244	30	possibly	possibly	RB
cord-006860-a3b8hyyr	244	31	working	work	VBG
cord-006860-a3b8hyyr	244	32	as	as	IN
cord-006860-a3b8hyyr	244	33	a	a	DT
cord-006860-a3b8hyyr	244	34	trigger	trigger	NN
cord-006860-a3b8hyyr	244	35	factor	factor	NN
cord-006860-a3b8hyyr	244	36	is	be	VBZ
cord-006860-a3b8hyyr	244	37	unknown	unknown	JJ
cord-006860-a3b8hyyr	244	38	yet	yet	RB
cord-006860-a3b8hyyr	244	39	.	.	.
cord-006860-a3b8hyyr	245	1	Some	some	DT
cord-006860-a3b8hyyr	245	2	authors	author	NNS
cord-006860-a3b8hyyr	245	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	245	4	HCYS	HCYS	NNP
cord-006860-a3b8hyyr	245	5	-	-	HYPH
cord-006860-a3b8hyyr	245	6	iaduced	iaduce	VBN
cord-006860-a3b8hyyr	245	7	effect	effect	NN
cord-006860-a3b8hyyr	245	8	on	on	IN
cord-006860-a3b8hyyr	245	9	factor	factor	NN
cord-006860-a3b8hyyr	245	10	V	v	NN
cord-006860-a3b8hyyr	245	11	activation	activation	NN
cord-006860-a3b8hyyr	245	12	or	or	CC
cord-006860-a3b8hyyr	245	13	inhibition	inhibition	NN
cord-006860-a3b8hyyr	245	14	of	of	IN
cord-006860-a3b8hyyr	245	15	thrombomodalin	thrombomodalin	JJ
cord-006860-a3b8hyyr	245	16	-	-	HYPH
cord-006860-a3b8hyyr	245	17	dependent	dependent	JJ
cord-006860-a3b8hyyr	245	18	protein	protein	NN
cord-006860-a3b8hyyr	245	19	C	C	NNP
cord-006860-a3b8hyyr	245	20	activation	activation	NN
cord-006860-a3b8hyyr	245	21	.	.	.
cord-006860-a3b8hyyr	246	1	In	in	IN
cord-006860-a3b8hyyr	246	2	addition	addition	NN
cord-006860-a3b8hyyr	246	3	an	an	DT
cord-006860-a3b8hyyr	246	4	influence	influence	NN
cord-006860-a3b8hyyr	246	5	on	on	IN
cord-006860-a3b8hyyr	246	6	thrombocyte	thrombocyte	NNP
cord-006860-a3b8hyyr	246	7	aggregation	aggregation	NN
cord-006860-a3b8hyyr	246	8	has	have	VBZ
cord-006860-a3b8hyyr	246	9	been	be	VBN
cord-006860-a3b8hyyr	246	10	postulated	postulate	VBN
cord-006860-a3b8hyyr	246	11	.	.	.
cord-006860-a3b8hyyr	247	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	247	2	:	:	:
cord-006860-a3b8hyyr	248	1	Measurement	measurement	NN
cord-006860-a3b8hyyr	248	2	of	of	IN
cord-006860-a3b8hyyr	248	3	HCYS	HCYS	NNP
cord-006860-a3b8hyyr	248	4	levels	level	NNS
cord-006860-a3b8hyyr	248	5	may	may	MD
cord-006860-a3b8hyyr	248	6	be	be	VB
cord-006860-a3b8hyyr	248	7	useful	useful	JJ
cord-006860-a3b8hyyr	248	8	in	in	IN
cord-006860-a3b8hyyr	248	9	the	the	DT
cord-006860-a3b8hyyr	248	10	evaluation	evaluation	NN
cord-006860-a3b8hyyr	248	11	of	of	IN
cord-006860-a3b8hyyr	248	12	patients	patient	NNS
cord-006860-a3b8hyyr	248	13	with	with	IN
cord-006860-a3b8hyyr	248	14	a	a	DT
cord-006860-a3b8hyyr	248	15	history	history	NN
cord-006860-a3b8hyyr	248	16	of	of	IN
cord-006860-a3b8hyyr	248	17	juvenile	juvenile	JJ
cord-006860-a3b8hyyr	248	18	venous	venous	JJ
cord-006860-a3b8hyyr	248	19	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	248	20	and	and	CC
cord-006860-a3b8hyyr	248	21	could	could	MD
cord-006860-a3b8hyyr	248	22	be	be	VB
cord-006860-a3b8hyyr	248	23	clinically	clinically	RB
cord-006860-a3b8hyyr	248	24	important	important	JJ
cord-006860-a3b8hyyr	248	25	as	as	IN
cord-006860-a3b8hyyr	248	26	hyper	hyper	JJ
cord-006860-a3b8hyyr	248	27	-	-	JJ
cord-006860-a3b8hyyr	248	28	HCYS	HCYS	NNP
cord-006860-a3b8hyyr	248	29	is	be	VBZ
cord-006860-a3b8hyyr	248	30	easily	easily	RB
cord-006860-a3b8hyyr	248	31	corrected	correct	VBN
cord-006860-a3b8hyyr	248	32	by	by	IN
cord-006860-a3b8hyyr	248	33	vitamin	vitamin	NN
cord-006860-a3b8hyyr	248	34	supplementation	supplementation	NN
cord-006860-a3b8hyyr	248	35	.	.	.
cord-006860-a3b8hyyr	249	1	Detailed	detailed	JJ
cord-006860-a3b8hyyr	249	2	determination	determination	NN
cord-006860-a3b8hyyr	249	3	of	of	IN
cord-006860-a3b8hyyr	249	4	the	the	DT
cord-006860-a3b8hyyr	249	5	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	249	6	of	of	IN
cord-006860-a3b8hyyr	249	7	VTE	VTE	NNP
cord-006860-a3b8hyyr	249	8	in	in	IN
cord-006860-a3b8hyyr	249	9	patients	patient	NNS
cord-006860-a3b8hyyr	249	10	with	with	IN
cord-006860-a3b8hyyr	249	11	hyper	hyper	JJ
cord-006860-a3b8hyyr	249	12	-	-	JJ
cord-006860-a3b8hyyr	249	13	HCYS	HCYS	NNP
cord-006860-a3b8hyyr	249	14	should	should	MD
cord-006860-a3b8hyyr	249	15	be	be	VB
cord-006860-a3b8hyyr	249	16	the	the	DT
cord-006860-a3b8hyyr	249	17	aim	aim	NN
cord-006860-a3b8hyyr	249	18	of	of	IN
cord-006860-a3b8hyyr	249	19	further	further	JJ
cord-006860-a3b8hyyr	249	20	investigations	investigation	NNS
cord-006860-a3b8hyyr	249	21	.	.	.
cord-006860-a3b8hyyr	250	1	A	a	DT
cord-006860-a3b8hyyr	250	2	deficiency	deficiency	NN
cord-006860-a3b8hyyr	250	3	of	of	IN
cord-006860-a3b8hyyr	250	4	one	one	CD
cord-006860-a3b8hyyr	250	5	of	of	IN
cord-006860-a3b8hyyr	250	6	the	the	DT
cord-006860-a3b8hyyr	250	7	coagulation	coagulation	NN
cord-006860-a3b8hyyr	250	8	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	250	9	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	250	10	(	(	-LRB-
cord-006860-a3b8hyyr	250	11	AT	AT	NNP
cord-006860-a3b8hyyr	250	12	)	)	-RRB-
cord-006860-a3b8hyyr	250	13	,	,	,
cord-006860-a3b8hyyr	250	14	protein	protein	NN
cord-006860-a3b8hyyr	250	15	C	C	NNP
cord-006860-a3b8hyyr	250	16	(	(	-LRB-
cord-006860-a3b8hyyr	250	17	PC	PC	NNP
cord-006860-a3b8hyyr	250	18	)	)	-RRB-
cord-006860-a3b8hyyr	250	19	or	or	CC
cord-006860-a3b8hyyr	250	20	protein	protein	NN
cord-006860-a3b8hyyr	250	21	S	S	NNP
cord-006860-a3b8hyyr	250	22	(	(	-LRB-
cord-006860-a3b8hyyr	250	23	PS	PS	NNP
cord-006860-a3b8hyyr	250	24	)	)	-RRB-
cord-006860-a3b8hyyr	250	25	and	and	CC
cord-006860-a3b8hyyr	250	26	resistance	resistance	NN
cord-006860-a3b8hyyr	250	27	to	to	IN
cord-006860-a3b8hyyr	250	28	activated	activate	VBN
cord-006860-a3b8hyyr	250	29	protein	protein	NN
cord-006860-a3b8hyyr	250	30	C	C	NNP
cord-006860-a3b8hyyr	250	31	(	(	-LRB-
cord-006860-a3b8hyyr	250	32	APC	APC	NNP
cord-006860-a3b8hyyr	250	33	resistance	resistance	NN
cord-006860-a3b8hyyr	250	34	)	)	-RRB-
cord-006860-a3b8hyyr	250	35	are	be	VBP
cord-006860-a3b8hyyr	250	36	established	establish	VBN
cord-006860-a3b8hyyr	250	37	risk	risk	NN
cord-006860-a3b8hyyr	250	38	factors	factor	NNS
cord-006860-a3b8hyyr	250	39	for	for	IN
cord-006860-a3b8hyyr	250	40	venous	venous	JJ
cord-006860-a3b8hyyr	250	41	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	250	42	(	(	-LRB-
cord-006860-a3b8hyyr	250	43	VTE	VTE	NNP
cord-006860-a3b8hyyr	250	44	)	)	-RRB-
cord-006860-a3b8hyyr	250	45	.	.	.
cord-006860-a3b8hyyr	251	1	In	in	IN
cord-006860-a3b8hyyr	251	2	the	the	DT
cord-006860-a3b8hyyr	251	3	majority	majority	NN
cord-006860-a3b8hyyr	251	4	of	of	IN
cord-006860-a3b8hyyr	251	5	patients	patient	NNS
cord-006860-a3b8hyyr	251	6	with	with	IN
cord-006860-a3b8hyyr	251	7	APC	APC	NNP
cord-006860-a3b8hyyr	251	8	resistance	resistance	NN
cord-006860-a3b8hyyr	251	9	,	,	,
cord-006860-a3b8hyyr	251	10	the	the	DT
cord-006860-a3b8hyyr	251	11	.tug	.tug	.
cord-006860-a3b8hyyr	251	12	506	506	CD
cord-006860-a3b8hyyr	251	13	Gin	Gin	NNP
cord-006860-a3b8hyyr	251	14	mutation	mutation	NN
cord-006860-a3b8hyyr	251	15	(	(	-LRB-
cord-006860-a3b8hyyr	251	16	Factor	factor	NN
cord-006860-a3b8hyyr	251	17	V	V	NNP
cord-006860-a3b8hyyr	251	18	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	251	19	)	)	-RRB-
cord-006860-a3b8hyyr	251	20	is	be	VBZ
cord-006860-a3b8hyyr	251	21	present	present	JJ
cord-006860-a3b8hyyr	251	22	.	.	.
cord-006860-a3b8hyyr	252	1	Whereas	whereas	IN
cord-006860-a3b8hyyr	252	2	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	252	3	of	of	IN
cord-006860-a3b8hyyr	252	4	one	one	CD
cord-006860-a3b8hyyr	252	5	of	of	IN
cord-006860-a3b8hyyr	252	6	the	the	DT
cord-006860-a3b8hyyr	252	7	coagulation	coagulation	NN
cord-006860-a3b8hyyr	252	8	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	252	9	are	be	VBP
cord-006860-a3b8hyyr	252	10	rare	rare	JJ
cord-006860-a3b8hyyr	252	11	in	in	IN
cord-006860-a3b8hyyr	252	12	the	the	DT
cord-006860-a3b8hyyr	252	13	normal	normal	JJ
cord-006860-a3b8hyyr	252	14	population	population	NN
cord-006860-a3b8hyyr	252	15	,	,	,
cord-006860-a3b8hyyr	252	16	the	the	DT
cord-006860-a3b8hyyr	252	17	allele	allele	NN
cord-006860-a3b8hyyr	252	18	frequency	frequency	NN
cord-006860-a3b8hyyr	252	19	of	of	IN
cord-006860-a3b8hyyr	252	20	factor	factor	NN
cord-006860-a3b8hyyr	252	21	V	V	NNP
cord-006860-a3b8hyyr	252	22	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	252	23	is	be	VBZ
cord-006860-a3b8hyyr	252	24	2	2	CD
cord-006860-a3b8hyyr	252	25	-	-	SYM
cord-006860-a3b8hyyr	252	26	7	7	CD
cord-006860-a3b8hyyr	252	27	%	%	NN
cord-006860-a3b8hyyr	252	28	in	in	IN
cord-006860-a3b8hyyr	252	29	Western	Western	NNP
cord-006860-a3b8hyyr	252	30	Europe	Europe	NNP
cord-006860-a3b8hyyr	252	31	.	.	.
cord-006860-a3b8hyyr	253	1	Heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	253	2	individuals	individual	NNS
cord-006860-a3b8hyyr	253	3	have	have	VBP
cord-006860-a3b8hyyr	253	4	a	a	DT
cord-006860-a3b8hyyr	253	5	3	3	CD
cord-006860-a3b8hyyr	253	6	-	-	SYM
cord-006860-a3b8hyyr	253	7	7fold	7fold	CD
cord-006860-a3b8hyyr	253	8	,	,	,
cord-006860-a3b8hyyr	253	9	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	253	10	an	an	DT
cord-006860-a3b8hyyr	253	11	80fold	80fold	JJ
cord-006860-a3b8hyyr	253	12	increased	increase	VBN
cord-006860-a3b8hyyr	253	13	risk	risk	NN
cord-006860-a3b8hyyr	253	14	for	for	IN
cord-006860-a3b8hyyr	253	15	VTE	VTE	NNP
cord-006860-a3b8hyyr	254	1	The	the	DT
cord-006860-a3b8hyyr	254	2	typical	typical	JJ
cord-006860-a3b8hyyr	254	3	clinical	clinical	JJ
cord-006860-a3b8hyyr	254	4	features	feature	NNS
cord-006860-a3b8hyyr	254	5	of	of	IN
cord-006860-a3b8hyyr	254	6	all	all	DT
cord-006860-a3b8hyyr	254	7	abnormalities	abnormality	NNS
cord-006860-a3b8hyyr	254	8	are	be	VBP
cord-006860-a3b8hyyr	254	9	deep	deep	JJ
cord-006860-a3b8hyyr	254	10	vein	vein	NN
cord-006860-a3b8hyyr	254	11	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	254	12	,	,	,
cord-006860-a3b8hyyr	254	13	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	254	14	embolism	embolism	NN
cord-006860-a3b8hyyr	254	15	,	,	,
cord-006860-a3b8hyyr	254	16	superficial	superficial	JJ
cord-006860-a3b8hyyr	254	17	vein	vein	NN
cord-006860-a3b8hyyr	254	18	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	254	19	and	and	CC
cord-006860-a3b8hyyr	254	20	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	254	21	at	at	IN
cord-006860-a3b8hyyr	254	22	unusual	unusual	JJ
cord-006860-a3b8hyyr	254	23	sites	site	NNS
cord-006860-a3b8hyyr	254	24	,	,	,
cord-006860-a3b8hyyr	254	25	like	like	IN
cord-006860-a3b8hyyr	254	26	mesenteric	mesenteric	JJ
cord-006860-a3b8hyyr	254	27	vein	vein	NN
cord-006860-a3b8hyyr	254	28	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	254	29	or	or	CC
cord-006860-a3b8hyyr	254	30	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	254	31	vein	vein	NN
cord-006860-a3b8hyyr	254	32	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	254	33	.	.	.
cord-006860-a3b8hyyr	255	1	The	the	DT
cord-006860-a3b8hyyr	255	2	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	255	3	risk	risk	NN
cord-006860-a3b8hyyr	255	4	is	be	VBZ
cord-006860-a3b8hyyr	255	5	low	low	JJ
cord-006860-a3b8hyyr	255	6	during	during	IN
cord-006860-a3b8hyyr	255	7	childhood	childhood	NN
cord-006860-a3b8hyyr	255	8	,	,	,
cord-006860-a3b8hyyr	255	9	but	but	CC
cord-006860-a3b8hyyr	255	10	increases	increase	VBZ
cord-006860-a3b8hyyr	255	11	considerably	considerably	RB
cord-006860-a3b8hyyr	255	12	after	after	IN
cord-006860-a3b8hyyr	255	13	the	the	DT
cord-006860-a3b8hyyr	255	14	13th	13th	JJ
cord-006860-a3b8hyyr	255	15	year	year	NN
cord-006860-a3b8hyyr	255	16	of	of	IN
cord-006860-a3b8hyyr	255	17	age	age	NN
cord-006860-a3b8hyyr	255	18	.	.	.
cord-006860-a3b8hyyr	256	1	A	a	DT
cord-006860-a3b8hyyr	256	2	retrospective	retrospective	JJ
cord-006860-a3b8hyyr	256	3	study	study	NN
cord-006860-a3b8hyyr	256	4	in	in	IN
cord-006860-a3b8hyyr	256	5	adult	adult	NN
cord-006860-a3b8hyyr	256	6	patients	patient	NNS
cord-006860-a3b8hyyr	256	7	out	out	IN
cord-006860-a3b8hyyr	256	8	of	of	IN
cord-006860-a3b8hyyr	256	9	families	family	NNS
cord-006860-a3b8hyyr	256	10	with	with	IN
cord-006860-a3b8hyyr	256	11	a	a	DT
cord-006860-a3b8hyyr	256	12	symptomatic	symptomatic	JJ
cord-006860-a3b8hyyr	256	13	deficiency	deficiency	NN
cord-006860-a3b8hyyr	256	14	of	of	IN
cord-006860-a3b8hyyr	256	15	AT	AT	NNP
cord-006860-a3b8hyyr	256	16	,	,	,
cord-006860-a3b8hyyr	256	17	PC	PC	NNP
cord-006860-a3b8hyyr	256	18	or	or	CC
cord-006860-a3b8hyyr	256	19	PS	PS	NNP
cord-006860-a3b8hyyr	256	20	revealed	reveal	VBD
cord-006860-a3b8hyyr	256	21	that	that	IN
cord-006860-a3b8hyyr	256	22	around	around	IN
cord-006860-a3b8hyyr	256	23	30	30	CD
cord-006860-a3b8hyyr	256	24	%	%	NN
cord-006860-a3b8hyyr	256	25	of	of	IN
cord-006860-a3b8hyyr	256	26	surgical	surgical	JJ
cord-006860-a3b8hyyr	256	27	interventions	intervention	NNS
cord-006860-a3b8hyyr	256	28	and	and	CC
cord-006860-a3b8hyyr	256	29	traumas	trauma	NNS
cord-006860-a3b8hyyr	256	30	of	of	IN
cord-006860-a3b8hyyr	256	31	the	the	DT
cord-006860-a3b8hyyr	256	32	lower	low	JJR
cord-006860-a3b8hyyr	256	33	extremities	extremity	NNS
cord-006860-a3b8hyyr	256	34	were	be	VBD
cord-006860-a3b8hyyr	256	35	complicated	complicate	VBN
cord-006860-a3b8hyyr	256	36	by	by	IN
cord-006860-a3b8hyyr	256	37	VTE	VTE	NNP
cord-006860-a3b8hyyr	256	38	.	.	.
cord-006860-a3b8hyyr	257	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	257	2	,	,	,
cord-006860-a3b8hyyr	257	3	these	these	DT
cord-006860-a3b8hyyr	257	4	patients	patient	NNS
cord-006860-a3b8hyyr	257	5	should	should	MD
cord-006860-a3b8hyyr	257	6	receive	receive	VB
cord-006860-a3b8hyyr	257	7	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	257	8	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	258	1	al	al	NNP
cord-006860-a3b8hyyr	258	2	~	~	NNP
cord-006860-a3b8hyyr	258	3	er	er	UH
cord-006860-a3b8hyyr	258	4	surgery	surgery	NN
cord-006860-a3b8hyyr	258	5	and	and	CC
cord-006860-a3b8hyyr	258	6	trauma	trauma	NN
cord-006860-a3b8hyyr	258	7	if	if	IN
cord-006860-a3b8hyyr	258	8	their	-PRON-	PRP$
cord-006860-a3b8hyyr	258	9	age	age	NN
cord-006860-a3b8hyyr	258	10	is	be	VBZ
cord-006860-a3b8hyyr	258	11	higher	high	JJR
cord-006860-a3b8hyyr	258	12	than	than	IN
cord-006860-a3b8hyyr	258	13	13	13	CD
cord-006860-a3b8hyyr	258	14	years	year	NNS
cord-006860-a3b8hyyr	258	15	.	.	.
cord-006860-a3b8hyyr	259	1	Pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	259	2	is	be	VBZ
cord-006860-a3b8hyyr	259	3	associated	associate	VBN
cord-006860-a3b8hyyr	259	4	with	with	IN
cord-006860-a3b8hyyr	259	5	a	a	DT
cord-006860-a3b8hyyr	259	6	very	very	RB
cord-006860-a3b8hyyr	259	7	high	high	JJ
cord-006860-a3b8hyyr	259	8	risk	risk	NN
cord-006860-a3b8hyyr	259	9	for	for	IN
cord-006860-a3b8hyyr	259	10	VTE	VTE	NNP
cord-006860-a3b8hyyr	259	11	in	in	IN
cord-006860-a3b8hyyr	259	12	individuals	individual	NNS
cord-006860-a3b8hyyr	259	13	with	with	IN
cord-006860-a3b8hyyr	259	14	AT	AT	NNP
cord-006860-a3b8hyyr	259	15	deficiency	deficiency	NN
cord-006860-a3b8hyyr	259	16	and	and	CC
cord-006860-a3b8hyyr	259	17	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	259	18	should	should	MD
cord-006860-a3b8hyyr	259	19	be	be	VB
cord-006860-a3b8hyyr	259	20	initiated	initiate	VBN
cord-006860-a3b8hyyr	259	21	already	already	RB
cord-006860-a3b8hyyr	259	22	in	in	IN
cord-006860-a3b8hyyr	259	23	the	the	DT
cord-006860-a3b8hyyr	259	24	first	first	JJ
cord-006860-a3b8hyyr	259	25	trimester	trimester	NN
cord-006860-a3b8hyyr	259	26	.	.	.
cord-006860-a3b8hyyr	260	1	After	after	IN
cord-006860-a3b8hyyr	260	2	delivery	delivery	NN
cord-006860-a3b8hyyr	260	3	,	,	,
cord-006860-a3b8hyyr	260	4	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	260	5	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	260	6	is	be	VBZ
cord-006860-a3b8hyyr	260	7	adviced	advice	VBN
cord-006860-a3b8hyyr	260	8	for	for	IN
cord-006860-a3b8hyyr	260	9	all	all	DT
cord-006860-a3b8hyyr	260	10	females	female	NNS
cord-006860-a3b8hyyr	260	11	known	know	VBN
cord-006860-a3b8hyyr	260	12	to	to	TO
cord-006860-a3b8hyyr	260	13	have	have	VB
cord-006860-a3b8hyyr	260	14	an	an	DT
cord-006860-a3b8hyyr	260	15	abnormality	abnormality	NN
cord-006860-a3b8hyyr	260	16	.	.	.
cord-006860-a3b8hyyr	261	1	OC	OC	NNP
cord-006860-a3b8hyyr	261	2	increase	increase	VB
cord-006860-a3b8hyyr	261	3	the	the	DT
cord-006860-a3b8hyyr	261	4	risk	risk	NN
cord-006860-a3b8hyyr	261	5	,	,	,
cord-006860-a3b8hyyr	261	6	especially	especially	RB
cord-006860-a3b8hyyr	261	7	in	in	IN
cord-006860-a3b8hyyr	261	8	AT	at	RB
cord-006860-a3b8hyyr	261	9	deficient	deficient	JJ
cord-006860-a3b8hyyr	261	10	and	and	CC
cord-006860-a3b8hyyr	261	11	in	in	IN
cord-006860-a3b8hyyr	261	12	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	261	13	factor	factor	NN
cord-006860-a3b8hyyr	261	14	V	V	NNP
cord-006860-a3b8hyyr	261	15	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	261	16	females	female	NNS
cord-006860-a3b8hyyr	261	17	and	and	CC
cord-006860-a3b8hyyr	261	18	are	be	VBP
cord-006860-a3b8hyyr	261	19	therefore	therefore	RB
cord-006860-a3b8hyyr	261	20	contraindicated	contraindicated	JJ
cord-006860-a3b8hyyr	261	21	in	in	IN
cord-006860-a3b8hyyr	261	22	these	these	DT
cord-006860-a3b8hyyr	261	23	individuals	individual	NNS
cord-006860-a3b8hyyr	261	24	.	.	.
cord-006860-a3b8hyyr	262	1	OC	OC	NNP
cord-006860-a3b8hyyr	262	2	do	do	VBP
cord-006860-a3b8hyyr	262	3	also	also	RB
cord-006860-a3b8hyyr	262	4	increase	increase	VB
cord-006860-a3b8hyyr	262	5	the	the	DT
cord-006860-a3b8hyyr	262	6	risk	risk	NN
cord-006860-a3b8hyyr	262	7	for	for	IN
cord-006860-a3b8hyyr	262	8	VTE	VTE	NNP
cord-006860-a3b8hyyr	262	9	in	in	IN
cord-006860-a3b8hyyr	262	10	patients	patient	NNS
cord-006860-a3b8hyyr	262	11	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	262	12	for	for	IN
cord-006860-a3b8hyyr	262	13	factor	factor	NN
cord-006860-a3b8hyyr	262	14	V	V	NNP
cord-006860-a3b8hyyr	262	15	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	262	16	and	and	CC
cord-006860-a3b8hyyr	262	17	females	female	NNS
cord-006860-a3b8hyyr	262	18	known	know	VBN
cord-006860-a3b8hyyr	262	19	to	to	TO
cord-006860-a3b8hyyr	262	20	have	have	VB
cord-006860-a3b8hyyr	262	21	this	this	DT
cord-006860-a3b8hyyr	262	22	abnormality	abnormality	NN
cord-006860-a3b8hyyr	262	23	should	should	MD
cord-006860-a3b8hyyr	262	24	be	be	VB
cord-006860-a3b8hyyr	262	25	discouraged	discourage	VBN
cord-006860-a3b8hyyr	262	26	from	from	IN
cord-006860-a3b8hyyr	262	27	taking	take	VBG
cord-006860-a3b8hyyr	262	28	OC	OC	NNP
cord-006860-a3b8hyyr	262	29	or	or	CC
cord-006860-a3b8hyyr	262	30	should	should	MD
cord-006860-a3b8hyyr	262	31	at	at	IN
cord-006860-a3b8hyyr	262	32	least	least	JJS
cord-006860-a3b8hyyr	262	33	be	be	VB
cord-006860-a3b8hyyr	262	34	informed	inform	VBN
cord-006860-a3b8hyyr	262	35	on	on	IN
cord-006860-a3b8hyyr	262	36	their	-PRON-	PRP$
cord-006860-a3b8hyyr	262	37	increased	increase	VBN
cord-006860-a3b8hyyr	262	38	risk	risk	NN
cord-006860-a3b8hyyr	262	39	.	.	.
cord-006860-a3b8hyyr	262	40	 	 	_SP
cord-006860-a3b8hyyr	263	1	University	University	NNP
cord-006860-a3b8hyyr	263	2	Hospital-	Hospital-	NNP
cord-006860-a3b8hyyr	263	3	'	'	''
cord-006860-a3b8hyyr	263	4	,	,	,
cord-006860-a3b8hyyr	263	5	Jerusalem	Jerusalem	NNP
cord-006860-a3b8hyyr	263	6	,	,	,
cord-006860-a3b8hyyr	263	7	Israel	Israel	NNP
cord-006860-a3b8hyyr	263	8	,	,	,
cord-006860-a3b8hyyr	263	9	Hospital	Hospital	NNP
cord-006860-a3b8hyyr	263	10	Bcan.iou	Bcan.iou	NNP
cord-006860-a3b8hyyr	264	1	~.	~.	NNP
cord-006860-a3b8hyyr	264	2	Paris	Paris	NNP
cord-006860-a3b8hyyr	264	3	,	,	,
cord-006860-a3b8hyyr	264	4	France	France	NNP
cord-006860-a3b8hyyr	264	5	,	,	,
cord-006860-a3b8hyyr	264	6	Increased	increase	VBN
cord-006860-a3b8hyyr	264	7	frequency	frequency	NN
cord-006860-a3b8hyyr	264	8	of	of	IN
cord-006860-a3b8hyyr	264	9	thrombocmbolie	thrombocmbolie	NN
cord-006860-a3b8hyyr	264	10	events	event	NNS
cord-006860-a3b8hyyr	264	11	have	have	VBP
cord-006860-a3b8hyyr	264	12	been	be	VBN
cord-006860-a3b8hyyr	264	13	observed	observe	VBN
cord-006860-a3b8hyyr	264	14	iu	iu	NNP
cord-006860-a3b8hyyr	264	15	patients	patient	NNS
cord-006860-a3b8hyyr	264	16	with	with	IN
cord-006860-a3b8hyyr	264	17	B	b	NN
cord-006860-a3b8hyyr	264	18	-	-	HYPH
cord-006860-a3b8hyyr	264	19	thalassemia	thalassemia	NN
cord-006860-a3b8hyyr	264	20	.	.	.
cord-006860-a3b8hyyr	265	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	265	2	findings	finding	NNS
cord-006860-a3b8hyyr	265	3	of	of	IN
cord-006860-a3b8hyyr	265	4	shortened	shorten	VBN
cord-006860-a3b8hyyr	265	5	platelet	platelet	NN
cord-006860-a3b8hyyr	265	6	survival	survival	NN
cord-006860-a3b8hyyr	265	7	and	and	CC
cord-006860-a3b8hyyr	265	8	enhanced	enhance	VBN
cord-006860-a3b8hyyr	265	9	urinary	urinary	JJ
cord-006860-a3b8hyyr	265	10	excretion	excretion	NN
cord-006860-a3b8hyyr	265	11	ofthmmboxanc	ofthmmboxanc	NNP
cord-006860-a3b8hyyr	266	1	A	a	DT
cord-006860-a3b8hyyr	266	2	:	:	:
cord-006860-a3b8hyyr	266	3	metabolitcs	metabolitcs	NNP
cord-006860-a3b8hyyr	266	4	(	(	-LRB-
cord-006860-a3b8hyyr	266	5	Blood	blood	NN
cord-006860-a3b8hyyr	266	6	77:1749	77:1749	CD
cord-006860-a3b8hyyr	267	1	(	(	-LRB-
cord-006860-a3b8hyyr	267	2	Blood	blood	NN
cord-006860-a3b8hyyr	267	3	77	77	CD
cord-006860-a3b8hyyr	267	4	:	:	:
cord-006860-a3b8hyyr	267	5	,	,	,
cord-006860-a3b8hyyr	267	6	1991	1991	CD
cord-006860-a3b8hyyr	267	7	suggested	suggest	VBD
cord-006860-a3b8hyyr	267	8	an	an	DT
cord-006860-a3b8hyyr	267	9	increased	increase	VBN
cord-006860-a3b8hyyr	267	10	platclet	platclet	NNP
cord-006860-a3b8hyyr	267	11	activation	activation	NN
cord-006860-a3b8hyyr	267	12	in	in	IN
cord-006860-a3b8hyyr	267	13	tbese	tbese	JJ
cord-006860-a3b8hyyr	267	14	patients	patient	NNS
cord-006860-a3b8hyyr	267	15	.	.	.
cord-006860-a3b8hyyr	268	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	268	2	also	also	RB
cord-006860-a3b8hyyr	268	3	fouud	fouud	VBP
cord-006860-a3b8hyyr	268	4	that	that	WDT
cord-006860-a3b8hyyr	268	5	isolated	isolate	VBD
cord-006860-a3b8hyyr	268	6	thalassemie	thalassemie	NNP
cord-006860-a3b8hyyr	268	7	RBC	RBC	NNP
cord-006860-a3b8hyyr	268	8	enhance	enhance	VB
cord-006860-a3b8hyyr	268	9	prothronlbin	prothronlbin	NNP
cord-006860-a3b8hyyr	268	10	activation	activation	NN
cord-006860-a3b8hyyr	268	11	,	,	,
cord-006860-a3b8hyyr	268	12	suggesting	suggest	VBG
cord-006860-a3b8hyyr	268	13	an	an	DT
cord-006860-a3b8hyyr	268	14	increased	increase	VBN
cord-006860-a3b8hyyr	268	15	membrane	membrane	NN
cord-006860-a3b8hyyr	268	16	exposure	exposure	NN
cord-006860-a3b8hyyr	268	17	of	of	IN
cord-006860-a3b8hyyr	268	18	procoagulant	procoagulant	NN
cord-006860-a3b8hyyr	268	19	phospholipids	phospholipid	NNS
cord-006860-a3b8hyyr	268	20	i.e	i.e	XX
cord-006860-a3b8hyyr	268	21	,	,	,
cord-006860-a3b8hyyr	268	22	phasphatidylserine	phasphatidylserine	FW
cord-006860-a3b8hyyr	268	23	(	(	-LRB-
cord-006860-a3b8hyyr	268	24	Am	be	VBP
cord-006860-a3b8hyyr	268	25	J.	J.	NNP
cord-006860-a3b8hyyr	268	26	Hematol	Hematol	NNP
cord-006860-a3b8hyyr	268	27	.	.	.
cord-006860-a3b8hyyr	268	28	44:33	44:33	CD
cord-006860-a3b8hyyr	268	29	,	,	,
cord-006860-a3b8hyyr	268	30	1993	1993	CD
cord-006860-a3b8hyyr	268	31	)	)	-RRB-
cord-006860-a3b8hyyr	268	32	.	.	.
cord-006860-a3b8hyyr	269	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	269	2	now	now	RB
cord-006860-a3b8hyyr	269	3	show	show	VBP
cord-006860-a3b8hyyr	269	4	that	that	IN
cord-006860-a3b8hyyr	269	5	annoxin	annoxin	NNP
cord-006860-a3b8hyyr	269	6	V	v	NN
cord-006860-a3b8hyyr	269	7	,	,	,
cord-006860-a3b8hyyr	269	8	which	which	WDT
cord-006860-a3b8hyyr	269	9	has	have	VBZ
cord-006860-a3b8hyyr	269	10	a	a	DT
cord-006860-a3b8hyyr	269	11	high	high	JJ
cord-006860-a3b8hyyr	269	12	specificity	specificity	NN
cord-006860-a3b8hyyr	269	13	and	and	CC
cord-006860-a3b8hyyr	269	14	affinity	affinity	NN
cord-006860-a3b8hyyr	269	15	for	for	IN
cord-006860-a3b8hyyr	269	16	anionic	anionic	JJ
cord-006860-a3b8hyyr	269	17	phospholipids	phospholipid	NNS
cord-006860-a3b8hyyr	269	18	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	269	19	pmthrombm	pmthrombm	NNP
cord-006860-a3b8hyyr	269	20	activation	activation	NN
cord-006860-a3b8hyyr	269	21	by	by	IN
cord-006860-a3b8hyyr	269	22	Factor	Factor	NNP
cord-006860-a3b8hyyr	269	23	Xa	Xa	NNP
cord-006860-a3b8hyyr	269	24	,	,	,
cord-006860-a3b8hyyr	269	25	by	by	IN
cord-006860-a3b8hyyr	269	26	binding	bind	VBG
cord-006860-a3b8hyyr	269	27	to	to	IN
cord-006860-a3b8hyyr	269	28	thalassemic	thalassemic	NNP
cord-006860-a3b8hyyr	269	29	RBC	RBC	NNP
cord-006860-a3b8hyyr	269	30	(	(	-LRB-
cord-006860-a3b8hyyr	269	31	IC~	IC~	NNP
cord-006860-a3b8hyyr	269	32	,	,	,
cord-006860-a3b8hyyr	269	33	=	=	SYM
cord-006860-a3b8hyyr	269	34	0.32	0.32	CD
cord-006860-a3b8hyyr	269	35	nM	nM	NNP
cord-006860-a3b8hyyr	269	36	)	)	-RRB-
cord-006860-a3b8hyyr	269	37	.	.	.
cord-006860-a3b8hyyr	270	1	Kerckhoff	Kerckhoff	NNP
cord-006860-a3b8hyyr	270	2	-	-	HYPH
cord-006860-a3b8hyyr	270	3	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	270	4	,	,	,
cord-006860-a3b8hyyr	270	5	Bad	bad	JJ
cord-006860-a3b8hyyr	270	6	Nauheim	Nauheim	NNP
cord-006860-a3b8hyyr	270	7	~	~	NFP
cord-006860-a3b8hyyr	270	8	,	,	,
cord-006860-a3b8hyyr	270	9	Medizinische	Medizinische	NNP
cord-006860-a3b8hyyr	270	10	Poliklinik	Poliklinik	NNP
cord-006860-a3b8hyyr	270	11	Bonn	Bonn	NNP
cord-006860-a3b8hyyr	270	12	2	2	CD
cord-006860-a3b8hyyr	270	13	,	,	,
cord-006860-a3b8hyyr	270	14	Institut	Institut	NNP
cord-006860-a3b8hyyr	270	15	for	for	IN
cord-006860-a3b8hyyr	270	16	Immunologie	Immunologie	NNP
cord-006860-a3b8hyyr	270	17	und	und	IN
cord-006860-a3b8hyyr	270	18	Transfusionsmedizin	Transfusionsmedizin	NNP
cord-006860-a3b8hyyr	270	19	Universit	Universit	NNP
cord-006860-a3b8hyyr	271	1	~ll	~ll	NNP
cord-006860-a3b8hyyr	272	1	Greifswald	Greifswald	NNP
cord-006860-a3b8hyyr	272	2	a	a	DT
cord-006860-a3b8hyyr	272	3	Antibody	antibody	NN
cord-006860-a3b8hyyr	272	4	-	-	HYPH
cord-006860-a3b8hyyr	272	5	mediated	mediate	VBN
cord-006860-a3b8hyyr	272	6	intravascular	intravascular	JJ
cord-006860-a3b8hyyr	272	7	platelet	platelet	NN
cord-006860-a3b8hyyr	272	8	activation	activation	NN
cord-006860-a3b8hyyr	272	9	is	be	VBZ
cord-006860-a3b8hyyr	272	10	believed	believe	VBN
cord-006860-a3b8hyyr	272	11	to	to	TO
cord-006860-a3b8hyyr	272	12	be	be	VB
cord-006860-a3b8hyyr	272	13	the	the	DT
cord-006860-a3b8hyyr	272	14	basis	basis	NN
cord-006860-a3b8hyyr	272	15	for	for	IN
cord-006860-a3b8hyyr	272	16	both	both	CC
cord-006860-a3b8hyyr	272	17	arterial	arterial	JJ
cord-006860-a3b8hyyr	272	18	and	and	CC
cord-006860-a3b8hyyr	272	19	venous	venous	JJ
cord-006860-a3b8hyyr	272	20	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	272	21	in	in	IN
cord-006860-a3b8hyyr	272	22	patients	patient	NNS
cord-006860-a3b8hyyr	272	23	with	with	IN
cord-006860-a3b8hyyr	272	24	HAT	hat	NN
cord-006860-a3b8hyyr	272	25	.	.	.
cord-006860-a3b8hyyr	273	1	While	while	IN
cord-006860-a3b8hyyr	273	2	the	the	DT
cord-006860-a3b8hyyr	273	3	development	development	NN
cord-006860-a3b8hyyr	273	4	of	of	IN
cord-006860-a3b8hyyr	273	5	arterial	arterial	JJ
cord-006860-a3b8hyyr	273	6	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	273	7	can	can	MD
cord-006860-a3b8hyyr	273	8	explained	explain	VBN
cord-006860-a3b8hyyr	273	9	sufficiently	sufficiently	RB
cord-006860-a3b8hyyr	273	10	by	by	IN
cord-006860-a3b8hyyr	273	11	intravascular	intravascular	JJ
cord-006860-a3b8hyyr	273	12	platelet	platelet	NN
cord-006860-a3b8hyyr	273	13	activation	activation	NN
cord-006860-a3b8hyyr	273	14	,	,	,
cord-006860-a3b8hyyr	273	15	it	-PRON-	PRP
cord-006860-a3b8hyyr	273	16	is	be	VBZ
cord-006860-a3b8hyyr	273	17	a	a	DT
cord-006860-a3b8hyyr	273	18	matter	matter	NN
cord-006860-a3b8hyyr	273	19	of	of	IN
cord-006860-a3b8hyyr	273	20	discussion	discussion	NN
cord-006860-a3b8hyyr	273	21	whether	whether	IN
cord-006860-a3b8hyyr	273	22	additional	additional	JJ
cord-006860-a3b8hyyr	273	23	risk	risk	NN
cord-006860-a3b8hyyr	273	24	factors	factor	NNS
cord-006860-a3b8hyyr	273	25	are	be	VBP
cord-006860-a3b8hyyr	273	26	involved	involve	VBN
cord-006860-a3b8hyyr	273	27	in	in	IN
cord-006860-a3b8hyyr	273	28	the	the	DT
cord-006860-a3b8hyyr	273	29	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	273	30	of	of	IN
cord-006860-a3b8hyyr	273	31	HAT	hat	NN
cord-006860-a3b8hyyr	273	32	-	-	HYPH
cord-006860-a3b8hyyr	273	33	related	relate	VBN
cord-006860-a3b8hyyr	273	34	venous	venous	JJ
cord-006860-a3b8hyyr	273	35	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	273	36	.	.	.
cord-006860-a3b8hyyr	274	1	Since	since	IN
cord-006860-a3b8hyyr	274	2	resistance	resistance	NN
cord-006860-a3b8hyyr	274	3	to	to	IN
cord-006860-a3b8hyyr	274	4	activated	activate	VBN
cord-006860-a3b8hyyr	274	5	protein	protein	NN
cord-006860-a3b8hyyr	274	6	C	C	NNP
cord-006860-a3b8hyyr	274	7	(	(	-LRB-
cord-006860-a3b8hyyr	274	8	APC	APC	NNP
cord-006860-a3b8hyyr	274	9	)	)	-RRB-
cord-006860-a3b8hyyr	274	10	is	be	VBZ
cord-006860-a3b8hyyr	274	11	the	the	DT
cord-006860-a3b8hyyr	274	12	most	most	RBS
cord-006860-a3b8hyyr	274	13	common	common	JJ
cord-006860-a3b8hyyr	274	14	inherited	inherit	VBN
cord-006860-a3b8hyyr	274	15	risk	risk	NN
cord-006860-a3b8hyyr	274	16	factor	factor	NN
cord-006860-a3b8hyyr	274	17	for	for	IN
cord-006860-a3b8hyyr	274	18	venous	venous	JJ
cord-006860-a3b8hyyr	274	19	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	274	20	described	describe	VBD
cord-006860-a3b8hyyr	274	21	the	the	DT
cord-006860-a3b8hyyr	274	22	frequency	frequency	NN
cord-006860-a3b8hyyr	274	23	of	of	IN
cord-006860-a3b8hyyr	274	24	APC	APC	NNP
cord-006860-a3b8hyyr	274	25	resistance	resistance	NN
cord-006860-a3b8hyyr	274	26	among	among	IN
cord-006860-a3b8hyyr	274	27	a	a	DT
cord-006860-a3b8hyyr	274	28	population	population	NN
cord-006860-a3b8hyyr	274	29	of	of	IN
cord-006860-a3b8hyyr	274	30	68	68	CD
cord-006860-a3b8hyyr	274	31	HAT	hat	NN
cord-006860-a3b8hyyr	274	32	patients	patient	NNS
cord-006860-a3b8hyyr	274	33	has	have	VBZ
cord-006860-a3b8hyyr	274	34	been	be	VBN
cord-006860-a3b8hyyr	274	35	studied	study	VBN
cord-006860-a3b8hyyr	274	36	.	.	.
cord-006860-a3b8hyyr	275	1	HAT	hat	NN
cord-006860-a3b8hyyr	275	2	was	be	VBD
cord-006860-a3b8hyyr	275	3	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	275	4	using	use	VBG
cord-006860-a3b8hyyr	275	5	the	the	DT
cord-006860-a3b8hyyr	275	6	heparin	heparin	NN
cord-006860-a3b8hyyr	275	7	-	-	HYPH
cord-006860-a3b8hyyr	275	8	induced	induce	VBN
cord-006860-a3b8hyyr	275	9	platelet	platelet	NN
cord-006860-a3b8hyyr	275	10	aggregation	aggregation	NN
cord-006860-a3b8hyyr	275	11	assay	assay	NN
cord-006860-a3b8hyyr	275	12	and	and	CC
cord-006860-a3b8hyyr	275	13	confirmed	confirm	VBN
cord-006860-a3b8hyyr	275	14	by	by	IN
cord-006860-a3b8hyyr	275	15	the	the	DT
cord-006860-a3b8hyyr	275	16	~4C	~4c	JJ
cord-006860-a3b8hyyr	275	17	-	-	HYPH
cord-006860-a3b8hyyr	275	18	serotoninrelease	serotoninrelease	NN
cord-006860-a3b8hyyr	275	19	test	test	NN
cord-006860-a3b8hyyr	275	20	.	.	.
cord-006860-a3b8hyyr	276	1	The	the	DT
cord-006860-a3b8hyyr	276	2	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	276	3	of	of	IN
cord-006860-a3b8hyyr	276	4	APC	APC	NNP
cord-006860-a3b8hyyr	276	5	resistance	resistance	NN
cord-006860-a3b8hyyr	276	6	was	be	VBD
cord-006860-a3b8hyyr	276	7	established	establish	VBN
cord-006860-a3b8hyyr	276	8	by	by	IN
cord-006860-a3b8hyyr	276	9	two	two	CD
cord-006860-a3b8hyyr	276	10	functional	functional	JJ
cord-006860-a3b8hyyr	276	11	assays	assay	NNS
cord-006860-a3b8hyyr	276	12	and	and	CC
cord-006860-a3b8hyyr	276	13	genetic	genetic	JJ
cord-006860-a3b8hyyr	276	14	analysis	analysis	NN
cord-006860-a3b8hyyr	276	15	.	.	.
cord-006860-a3b8hyyr	277	1	At	at	IN
cord-006860-a3b8hyyr	277	2	time	time	NN
cord-006860-a3b8hyyr	277	3	of	of	IN
cord-006860-a3b8hyyr	277	4	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	277	5	of	of	IN
cord-006860-a3b8hyyr	277	6	HAT	hat	NN
cord-006860-a3b8hyyr	277	7	,	,	,
cord-006860-a3b8hyyr	277	8	38	38	CD
cord-006860-a3b8hyyr	277	9	patients	patient	NNS
cord-006860-a3b8hyyr	277	10	showed	show	VBD
cord-006860-a3b8hyyr	277	11	venous	venous	JJ
cord-006860-a3b8hyyr	277	12	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	277	13	complications	complication	NNS
cord-006860-a3b8hyyr	277	14	.	.	.
cord-006860-a3b8hyyr	278	1	Among	among	IN
cord-006860-a3b8hyyr	278	2	these	these	DT
cord-006860-a3b8hyyr	278	3	,	,	,
cord-006860-a3b8hyyr	278	4	24	24	CD
cord-006860-a3b8hyyr	278	5	were	be	VBD
cord-006860-a3b8hyyr	278	6	found	find	VBN
cord-006860-a3b8hyyr	278	7	positive	positive	JJ
cord-006860-a3b8hyyr	278	8	for	for	IN
cord-006860-a3b8hyyr	278	9	APC	apc	NN
cord-006860-a3b8hyyr	278	10	-	-	HYPH
cord-006860-a3b8hyyr	278	11	resistance	resistance	NN
cord-006860-a3b8hyyr	278	12	.	.	.
cord-006860-a3b8hyyr	279	1	Pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	279	2	embolism	embolism	NN
cord-006860-a3b8hyyr	279	3	was	be	VBD
cord-006860-a3b8hyyr	279	4	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	279	5	in	in	IN
cord-006860-a3b8hyyr	279	6	18	18	CD
cord-006860-a3b8hyyr	279	7	HAT	hat	NN
cord-006860-a3b8hyyr	279	8	patients	patient	NNS
cord-006860-a3b8hyyr	279	9	,	,	,
cord-006860-a3b8hyyr	279	10	14	14	CD
cord-006860-a3b8hyyr	279	11	of	of	IN
cord-006860-a3b8hyyr	279	12	them	-PRON-	PRP
cord-006860-a3b8hyyr	279	13	were	be	VBD
cord-006860-a3b8hyyr	279	14	APC	APC	NNP
cord-006860-a3b8hyyr	279	15	resistance	resistance	NN
cord-006860-a3b8hyyr	279	16	positive	positive	JJ
cord-006860-a3b8hyyr	279	17	.	.	.
cord-006860-a3b8hyyr	280	1	None	none	NN
cord-006860-a3b8hyyr	280	2	of	of	IN
cord-006860-a3b8hyyr	280	3	the	the	DT
cord-006860-a3b8hyyr	280	4	18	18	CD
cord-006860-a3b8hyyr	280	5	HAT	hat	NN
cord-006860-a3b8hyyr	280	6	patients	patient	NNS
cord-006860-a3b8hyyr	280	7	who	who	WP
cord-006860-a3b8hyyr	280	8	showed	show	VBD
cord-006860-a3b8hyyr	280	9	exclusively	exclusively	RB
cord-006860-a3b8hyyr	280	10	thrombocytopenia	thrombocytopenia	NNS
cord-006860-a3b8hyyr	280	11	were	be	VBD
cord-006860-a3b8hyyr	280	12	APC	APC	NNP
cord-006860-a3b8hyyr	280	13	resistance	resistance	NN
cord-006860-a3b8hyyr	280	14	positive	positive	JJ
cord-006860-a3b8hyyr	280	15	.	.	.
cord-006860-a3b8hyyr	281	1	Early	early	JJ
cord-006860-a3b8hyyr	281	2	oral	oral	JJ
cord-006860-a3b8hyyr	281	3	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	281	4	(	(	-LRB-
cord-006860-a3b8hyyr	281	5	OA	OA	NNP
cord-006860-a3b8hyyr	281	6	)	)	-RRB-
cord-006860-a3b8hyyr	281	7	was	be	VBD
cord-006860-a3b8hyyr	281	8	initiated	initiate	VBN
cord-006860-a3b8hyyr	281	9	in	in	IN
cord-006860-a3b8hyyr	281	10	7	7	CD
cord-006860-a3b8hyyr	281	11	patients	patient	NNS
cord-006860-a3b8hyyr	281	12	after	after	IN
cord-006860-a3b8hyyr	281	13	the	the	DT
cord-006860-a3b8hyyr	281	14	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	281	15	of	of	IN
cord-006860-a3b8hyyr	281	16	HAT	HAT	NNP
cord-006860-a3b8hyyr	281	17	has	have	VBZ
cord-006860-a3b8hyyr	281	18	been	be	VBN
cord-006860-a3b8hyyr	281	19	established	establish	VBN
cord-006860-a3b8hyyr	281	20	.	.	.
cord-006860-a3b8hyyr	282	1	Six	six	CD
cord-006860-a3b8hyyr	282	2	of	of	IN
cord-006860-a3b8hyyr	282	3	these	these	DT
cord-006860-a3b8hyyr	282	4	patients	patient	NNS
cord-006860-a3b8hyyr	282	5	developed	develop	VBD
cord-006860-a3b8hyyr	282	6	serious	serious	JJ
cord-006860-a3b8hyyr	282	7	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	282	8	complications	complication	NNS
cord-006860-a3b8hyyr	282	9	including	include	VBG
cord-006860-a3b8hyyr	282	10	skin	skin	NN
cord-006860-a3b8hyyr	282	11	necrosis	necrosis	NN
cord-006860-a3b8hyyr	282	12	.	.	.
cord-006860-a3b8hyyr	283	1	These	these	DT
cord-006860-a3b8hyyr	283	2	results	result	NNS
cord-006860-a3b8hyyr	283	3	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	283	4	that	that	IN
cord-006860-a3b8hyyr	283	5	APC	APC	NNP
cord-006860-a3b8hyyr	283	6	resistance	resistance	NN
cord-006860-a3b8hyyr	283	7	is	be	VBZ
cord-006860-a3b8hyyr	283	8	an	an	DT
cord-006860-a3b8hyyr	283	9	additional	additional	JJ
cord-006860-a3b8hyyr	283	10	and	and	CC
cord-006860-a3b8hyyr	283	11	common	common	JJ
cord-006860-a3b8hyyr	283	12	risk	risk	NN
cord-006860-a3b8hyyr	283	13	factor	factor	NN
cord-006860-a3b8hyyr	283	14	for	for	IN
cord-006860-a3b8hyyr	283	15	the	the	DT
cord-006860-a3b8hyyr	283	16	development	development	NN
cord-006860-a3b8hyyr	283	17	of	of	IN
cord-006860-a3b8hyyr	283	18	HAT	hat	NN
cord-006860-a3b8hyyr	283	19	-	-	HYPH
cord-006860-a3b8hyyr	283	20	related	relate	VBN
cord-006860-a3b8hyyr	283	21	venous	venous	JJ
cord-006860-a3b8hyyr	283	22	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	283	23	.	.	.
cord-006860-a3b8hyyr	284	1	Early	early	JJ
cord-006860-a3b8hyyr	284	2	initiation	initiation	NN
cord-006860-a3b8hyyr	284	3	of	of	IN
cord-006860-a3b8hyyr	284	4	OA	OA	NNP
cord-006860-a3b8hyyr	284	5	during	during	IN
cord-006860-a3b8hyyr	284	6	an	an	DT
cord-006860-a3b8hyyr	284	7	acute	acute	JJ
cord-006860-a3b8hyyr	284	8	episode	episode	NN
cord-006860-a3b8hyyr	284	9	of	of	IN
cord-006860-a3b8hyyr	284	10	HAT	hat	NN
cord-006860-a3b8hyyr	284	11	dramatically	dramatically	RB
cord-006860-a3b8hyyr	284	12	increases	increase	VBZ
cord-006860-a3b8hyyr	284	13	the	the	DT
cord-006860-a3b8hyyr	284	14	risk	risk	NN
cord-006860-a3b8hyyr	284	15	of	of	IN
cord-006860-a3b8hyyr	284	16	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	284	17	.	.	.
cord-006860-a3b8hyyr	285	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	285	2	,	,	,
cord-006860-a3b8hyyr	285	3	OA	OA	NNP
cord-006860-a3b8hyyr	285	4	in	in	IN
cord-006860-a3b8hyyr	285	5	HAT	hat	NN
cord-006860-a3b8hyyr	285	6	patients	patient	NNS
cord-006860-a3b8hyyr	285	7	should	should	MD
cord-006860-a3b8hyyr	285	8	be	be	VB
cord-006860-a3b8hyyr	285	9	initiated	initiate	VBN
cord-006860-a3b8hyyr	285	10	only	only	RB
cord-006860-a3b8hyyr	285	11	after	after	IN
cord-006860-a3b8hyyr	285	12	platelet	platelet	NN
cord-006860-a3b8hyyr	285	13	counts	count	NNS
cord-006860-a3b8hyyr	285	14	have	have	VBP
cord-006860-a3b8hyyr	285	15	been	be	VBN
cord-006860-a3b8hyyr	285	16	returned	return	VBN
cord-006860-a3b8hyyr	285	17	to	to	IN
cord-006860-a3b8hyyr	285	18	baseline	baseline	JJ
cord-006860-a3b8hyyr	285	19	levels	level	NNS
cord-006860-a3b8hyyr	285	20	and	and	CC
cord-006860-a3b8hyyr	285	21	effective	effective	JJ
cord-006860-a3b8hyyr	285	22	parenteral	parenteral	JJ
cord-006860-a3b8hyyr	285	23	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	285	24	is	be	VBZ
cord-006860-a3b8hyyr	285	25	achieved	achieve	VBN
cord-006860-a3b8hyyr	285	26	.	.	.
cord-006860-a3b8hyyr	286	1	CONTROLLED	CONTROLLED	NNP
cord-006860-a3b8hyyr	286	2	TRIALS	trial	NNS
cord-006860-a3b8hyyr	286	3	FOR	for	IN
cord-006860-a3b8hyyr	286	4	PRIMARY	primary	JJ
cord-006860-a3b8hyyr	286	5	AND	and	CC
cord-006860-a3b8hyyr	286	6	SECONDARY	secondary	JJ
cord-006860-a3b8hyyr	286	7	PREVENTION	prevention	NN
cord-006860-a3b8hyyr	286	8	OF	of	IN
cord-006860-a3b8hyyr	286	9	STROKE	stroke	NN
cord-006860-a3b8hyyr	286	10	G.	G.	NNP
cord-006860-a3b8hyyr	286	11	de	de	NNP
cord-006860-a3b8hyyr	286	12	(	(	-LRB-
cord-006860-a3b8hyyr	286	13	3aetano	3aetano	CD
cord-006860-a3b8hyyr	286	14	,	,	,
cord-006860-a3b8hyyr	286	15	C.	C.	NNP
cord-006860-a3b8hyyr	286	16	Cerletti	Cerletti	NNP
cord-006860-a3b8hyyr	286	17	and	and	CC
cord-006860-a3b8hyyr	287	1	V.	V.	NNP
cord-006860-a3b8hyyr	287	2	Bertel~	Bertel~	NNP
cord-006860-a3b8hyyr	288	1	Consorzio	Consorzio	NNP
cord-006860-a3b8hyyr	288	2	Mario	Mario	NNP
cord-006860-a3b8hyyr	288	3	Negri	Negri	NNP
cord-006860-a3b8hyyr	288	4	Sud	Sud	NNP
cord-006860-a3b8hyyr	288	5	,	,	,
cord-006860-a3b8hyyr	288	6	Santa	Santa	NNP
cord-006860-a3b8hyyr	288	7	Maria	Maria	NNP
cord-006860-a3b8hyyr	288	8	Imbaro	Imbaro	NNP
cord-006860-a3b8hyyr	288	9	,	,	,
cord-006860-a3b8hyyr	288	10	Italy	Italy	NNP
cord-006860-a3b8hyyr	289	1	This	this	DT
cord-006860-a3b8hyyr	289	2	presentation	presentation	NN
cord-006860-a3b8hyyr	289	3	will	will	MD
cord-006860-a3b8hyyr	289	4	review	review	VB
cord-006860-a3b8hyyr	289	5	the	the	DT
cord-006860-a3b8hyyr	289	6	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	289	7	treatments	treatment	NNS
cord-006860-a3b8hyyr	289	8	to	to	TO
cord-006860-a3b8hyyr	289	9	prevent	prevent	VB
cord-006860-a3b8hyyr	289	10	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	289	11	stroke	stroke	NN
cord-006860-a3b8hyyr	289	12	that	that	WDT
cord-006860-a3b8hyyr	289	13	have	have	VBP
cord-006860-a3b8hyyr	289	14	been	be	VBN
cord-006860-a3b8hyyr	289	15	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	289	16	in	in	IN
cord-006860-a3b8hyyr	289	17	controlled	control	VBN
cord-006860-a3b8hyyr	289	18	clinical	clinical	JJ
cord-006860-a3b8hyyr	289	19	trials	trial	NNS
cord-006860-a3b8hyyr	289	20	.	.	.
cord-006860-a3b8hyyr	290	1	In	in	IN
cord-006860-a3b8hyyr	290	2	two	two	CD
cord-006860-a3b8hyyr	290	3	studies	study	NNS
cord-006860-a3b8hyyr	290	4	of	of	IN
cord-006860-a3b8hyyr	290	5	aspirin	aspirin	NN
cord-006860-a3b8hyyr	290	6	therapy	therapy	NN
cord-006860-a3b8hyyr	290	7	for	for	IN
cord-006860-a3b8hyyr	290	8	pdmary	pdmary	NNP
cord-006860-a3b8hyyr	290	9	prevention	prevention	NNP
cord-006860-a3b8hyyr	290	10	in	in	IN
cord-006860-a3b8hyyr	290	11	male	male	JJ
cord-006860-a3b8hyyr	290	12	physicians	physician	NNS
cord-006860-a3b8hyyr	290	13	there	there	EX
cord-006860-a3b8hyyr	290	14	was	be	VBD
cord-006860-a3b8hyyr	290	15	no	no	DT
cord-006860-a3b8hyyr	290	16	reduction	reduction	NN
cord-006860-a3b8hyyr	290	17	in	in	IN
cord-006860-a3b8hyyr	290	18	the	the	DT
cord-006860-a3b8hyyr	290	19	incidence	incidence	NN
cord-006860-a3b8hyyr	290	20	of	of	IN
cord-006860-a3b8hyyr	290	21	stroke	stroke	NN
cord-006860-a3b8hyyr	290	22	,	,	,
cord-006860-a3b8hyyr	290	23	while	while	IN
cord-006860-a3b8hyyr	290	24	that	that	DT
cord-006860-a3b8hyyr	290	25	of	of	IN
cord-006860-a3b8hyyr	290	26	first	first	JJ
cord-006860-a3b8hyyr	290	27	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	290	28	infarction	infarction	NN
cord-006860-a3b8hyyr	290	29	was	be	VBD
cord-006860-a3b8hyyr	290	30	significantly	significantly	RB
cord-006860-a3b8hyyr	290	31	lowered	lower	VBN
cord-006860-a3b8hyyr	290	32	.	.	.
cord-006860-a3b8hyyr	291	1	Similar	similar	JJ
cord-006860-a3b8hyyr	291	2	results	result	NNS
cord-006860-a3b8hyyr	291	3	were	be	VBD
cord-006860-a3b8hyyr	291	4	obtained	obtain	VBN
cord-006860-a3b8hyyr	291	5	in	in	IN
cord-006860-a3b8hyyr	291	6	a	a	DT
cord-006860-a3b8hyyr	291	7	prospective	prospective	JJ
cord-006860-a3b8hyyr	291	8	study	study	NN
cord-006860-a3b8hyyr	291	9	in	in	IN
cord-006860-a3b8hyyr	291	10	a	a	DT
cord-006860-a3b8hyyr	291	11	large	large	JJ
cord-006860-a3b8hyyr	291	12	cohort	cohort	NN
cord-006860-a3b8hyyr	291	13	of	of	IN
cord-006860-a3b8hyyr	291	14	women	woman	NNS
cord-006860-a3b8hyyr	291	15	taking	take	VBG
cord-006860-a3b8hyyr	291	16	aspirin	aspirin	NN
cord-006860-a3b8hyyr	291	17	daily	daily	RB
cord-006860-a3b8hyyr	291	18	.	.	.
cord-006860-a3b8hyyr	292	1	The	the	DT
cord-006860-a3b8hyyr	292	2	incidence	incidence	NN
cord-006860-a3b8hyyr	292	3	of	of	IN
cord-006860-a3b8hyyr	292	4	vascular	vascular	JJ
cord-006860-a3b8hyyr	292	5	death	death	NN
cord-006860-a3b8hyyr	292	6	was	be	VBD
cord-006860-a3b8hyyr	292	7	not	not	RB
cord-006860-a3b8hyyr	292	8	modified	modify	VBN
cord-006860-a3b8hyyr	292	9	by	by	IN
cord-006860-a3b8hyyr	292	10	aspirin	aspirin	NN
cord-006860-a3b8hyyr	292	11	in	in	IN
cord-006860-a3b8hyyr	292	12	any	any	DT
cord-006860-a3b8hyyr	292	13	of	of	IN
cord-006860-a3b8hyyr	292	14	these	these	DT
cord-006860-a3b8hyyr	292	15	trials	trial	NNS
cord-006860-a3b8hyyr	292	16	.	.	.
cord-006860-a3b8hyyr	293	1	This	this	DT
cord-006860-a3b8hyyr	293	2	is	be	VBZ
cord-006860-a3b8hyyr	293	3	possibly	possibly	RB
cord-006860-a3b8hyyr	293	4	due	due	JJ
cord-006860-a3b8hyyr	293	5	.to	.to	.
cord-006860-a3b8hyyr	294	1	an	an	DT
cord-006860-a3b8hyyr	294	2	excess	excess	NN
cord-006860-a3b8hyyr	294	3	of	of	IN
cord-006860-a3b8hyyr	294	4	strokes	stroke	NNS
cord-006860-a3b8hyyr	294	5	associated	associate	VBN
cord-006860-a3b8hyyr	294	6	to	to	IN
cord-006860-a3b8hyyr	294	7	aspirin	aspirin	NN
cord-006860-a3b8hyyr	294	8	treatment	treatment	NN
cord-006860-a3b8hyyr	294	9	:	:	:
cord-006860-a3b8hyyr	294	10	indeed	indeed	RB
cord-006860-a3b8hyyr	294	11	the	the	DT
cord-006860-a3b8hyyr	294	12	four	four	CD
cord-006860-a3b8hyyr	294	13	vascular	vascular	JJ
cord-006860-a3b8hyyr	294	14	events	event	NNS
cord-006860-a3b8hyyr	294	15	avoided	avoid	VBN
cord-006860-a3b8hyyr	294	16	in	in	IN
cord-006860-a3b8hyyr	294	17	1000	1000	CD
cord-006860-a3b8hyyr	294	18	US	US	NNP
cord-006860-a3b8hyyr	294	19	physicians	physician	NNS
cord-006860-a3b8hyyr	294	20	under	under	IN
cord-006860-a3b8hyyr	294	21	aspirin	aspirin	NN
cord-006860-a3b8hyyr	294	22	prevention	prevention	NN
cord-006860-a3b8hyyr	294	23	for	for	IN
cord-006860-a3b8hyyr	294	24	five	five	CD
cord-006860-a3b8hyyr	294	25	years	year	NNS
cord-006860-a3b8hyyr	294	26	would	would	MD
cord-006860-a3b8hyyr	294	27	result	result	VB
cord-006860-a3b8hyyr	294	28	from	from	IN
cord-006860-a3b8hyyr	294	29	five	five	CD
cord-006860-a3b8hyyr	294	30	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	294	31	infarction	infarction	NN
cord-006860-a3b8hyyr	294	32	and	and	CC
cord-006860-a3b8hyyr	294	33	one	one	CD
cord-006860-a3b8hyyr	294	34	vascular	vascular	JJ
cord-006860-a3b8hyyr	294	35	death	death	NN
cord-006860-a3b8hyyr	294	36	avoided	avoid	VBN
cord-006860-a3b8hyyr	294	37	and	and	CC
cord-006860-a3b8hyyr	294	38	two	two	CD
cord-006860-a3b8hyyr	294	39	additional	additional	JJ
cord-006860-a3b8hyyr	294	40	strokes	stroke	NNS
cord-006860-a3b8hyyr	294	41	occurred	occur	VBD
cord-006860-a3b8hyyr	294	42	.	.	.
cord-006860-a3b8hyyr	295	1	Oral	oral	JJ
cord-006860-a3b8hyyr	295	2	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	295	3	therapy	therapy	NN
cord-006860-a3b8hyyr	295	4	decreases	decrease	VBZ
cord-006860-a3b8hyyr	295	5	the	the	DT
cord-006860-a3b8hyyr	295	6	relative	relative	JJ
cord-006860-a3b8hyyr	295	7	risk	risk	NN
cord-006860-a3b8hyyr	295	8	of	of	IN
cord-006860-a3b8hyyr	295	9	stroke	stroke	NN
cord-006860-a3b8hyyr	295	10	in	in	IN
cord-006860-a3b8hyyr	295	11	patients	patient	NNS
cord-006860-a3b8hyyr	295	12	with	with	IN
cord-006860-a3b8hyyr	295	13	non	non	JJ
cord-006860-a3b8hyyr	295	14	valvular	valvular	JJ
cord-006860-a3b8hyyr	295	15	atrial	atrial	JJ
cord-006860-a3b8hyyr	295	16	fibrillation	fibrillation	NN
cord-006860-a3b8hyyr	295	17	.	.	.
cord-006860-a3b8hyyr	296	1	Warfarin	Warfarin	NNP
cord-006860-a3b8hyyr	296	2	appears	appear	VBZ
cord-006860-a3b8hyyr	296	3	to	to	TO
cord-006860-a3b8hyyr	296	4	be	be	VB
cord-006860-a3b8hyyr	296	5	superior	superior	JJ
cord-006860-a3b8hyyr	296	6	to	to	IN
cord-006860-a3b8hyyr	296	7	aspirin	aspirin	NN
cord-006860-a3b8hyyr	296	8	,	,	,
cord-006860-a3b8hyyr	296	9	but	but	CC
cord-006860-a3b8hyyr	296	10	the	the	DT
cord-006860-a3b8hyyr	296	11	latter	latter	JJ
cord-006860-a3b8hyyr	296	12	drug	drug	NN
cord-006860-a3b8hyyr	296	13	is	be	VBZ
cord-006860-a3b8hyyr	296	14	a	a	DT
cord-006860-a3b8hyyr	296	15	useful	useful	JJ
cord-006860-a3b8hyyr	296	16	alternative	alternative	NN
cord-006860-a3b8hyyr	296	17	when	when	WRB
cord-006860-a3b8hyyr	296	18	long	long	JJ
cord-006860-a3b8hyyr	296	19	-	-	HYPH
cord-006860-a3b8hyyr	296	20	term	term	NN
cord-006860-a3b8hyyr	296	21	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	296	22	therapy	therapy	NN
cord-006860-a3b8hyyr	296	23	can	can	MD
cord-006860-a3b8hyyr	296	24	not	not	RB
cord-006860-a3b8hyyr	296	25	be	be	VB
cord-006860-a3b8hyyr	296	26	administered	administer	VBN
cord-006860-a3b8hyyr	296	27	.	.	.
cord-006860-a3b8hyyr	297	1	A	a	DT
cord-006860-a3b8hyyr	297	2	metanalysis	metanalysis	NN
cord-006860-a3b8hyyr	297	3	of	of	IN
cord-006860-a3b8hyyr	297	4	about	about	RB
cord-006860-a3b8hyyr	297	5	150	150	CD
cord-006860-a3b8hyyr	297	6	trials	trial	NNS
cord-006860-a3b8hyyr	297	7	and	and	CC
cord-006860-a3b8hyyr	297	8	over	over	IN
cord-006860-a3b8hyyr	297	9	100,000	100,000	CD
cord-006860-a3b8hyyr	297	10	patients	patient	NNS
cord-006860-a3b8hyyr	297	11	with	with	IN
cord-006860-a3b8hyyr	297	12	different	different	JJ
cord-006860-a3b8hyyr	297	13	vascular	vascular	JJ
cord-006860-a3b8hyyr	297	14	diseases	disease	NNS
cord-006860-a3b8hyyr	297	15	treated	treat	VBN
cord-006860-a3b8hyyr	297	16	with	with	IN
cord-006860-a3b8hyyr	297	17	aspirin	aspirin	NN
cord-006860-a3b8hyyr	297	18	(	(	-LRB-
cord-006860-a3b8hyyr	297	19	at	at	IN
cord-006860-a3b8hyyr	297	20	different	different	JJ
cord-006860-a3b8hyyr	297	21	doses	dose	NNS
cord-006860-a3b8hyyr	297	22	)	)	-RRB-
cord-006860-a3b8hyyr	298	1	and/or	and/or	CC
cord-006860-a3b8hyyr	298	2	other	other	JJ
cord-006860-a3b8hyyr	298	3	platelet	platelet	NN
cord-006860-a3b8hyyr	298	4	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	298	5	showed	show	VBD
cord-006860-a3b8hyyr	298	6	25	25	CD
cord-006860-a3b8hyyr	298	7	%	%	NN
cord-006860-a3b8hyyr	298	8	overall	overall	JJ
cord-006860-a3b8hyyr	298	9	reduction	reduction	NN
cord-006860-a3b8hyyr	298	10	of	of	IN
cord-006860-a3b8hyyr	298	11	vascular	vascular	JJ
cord-006860-a3b8hyyr	298	12	events	event	NNS
cord-006860-a3b8hyyr	298	13	including	include	VBG
cord-006860-a3b8hyyr	298	14	stroke	stroke	NN
cord-006860-a3b8hyyr	298	15	.	.	.
cord-006860-a3b8hyyr	299	1	The	the	DT
cord-006860-a3b8hyyr	299	2	optimal	optimal	JJ
cord-006860-a3b8hyyr	299	3	dose	dose	NN
cord-006860-a3b8hyyr	299	4	of	of	IN
cord-006860-a3b8hyyr	299	5	aspirin	aspirin	NN
cord-006860-a3b8hyyr	299	6	for	for	IN
cord-006860-a3b8hyyr	299	7	secondary	secondary	JJ
cord-006860-a3b8hyyr	299	8	stroke	stroke	NN
cord-006860-a3b8hyyr	299	9	prevention	prevention	NN
cord-006860-a3b8hyyr	299	10	could	could	MD
cord-006860-a3b8hyyr	299	11	not	not	RB
cord-006860-a3b8hyyr	299	12	be	be	VB
cord-006860-a3b8hyyr	299	13	established	establish	VBN
cord-006860-a3b8hyyr	299	14	.	.	.
cord-006860-a3b8hyyr	300	1	In	in	IN
cord-006860-a3b8hyyr	300	2	patients	patient	NNS
cord-006860-a3b8hyyr	300	3	with	with	IN
cord-006860-a3b8hyyr	300	4	previous	previous	JJ
cord-006860-a3b8hyyr	300	5	minor	minor	JJ
cord-006860-a3b8hyyr	300	6	strokes	stroke	NNS
cord-006860-a3b8hyyr	300	7	or	or	CC
cord-006860-a3b8hyyr	300	8	TIA	TIA	NNP
cord-006860-a3b8hyyr	300	9	there	there	EX
cord-006860-a3b8hyyr	300	10	was	be	VBD
cord-006860-a3b8hyyr	300	11	22	22	CD
cord-006860-a3b8hyyr	300	12	%	%	NN
cord-006860-a3b8hyyr	300	13	reduction	reduction	NN
cord-006860-a3b8hyyr	300	14	of	of	IN
cord-006860-a3b8hyyr	300	15	vascular	vascular	JJ
cord-006860-a3b8hyyr	300	16	events	event	NNS
cord-006860-a3b8hyyr	300	17	and	and	CC
cord-006860-a3b8hyyr	300	18	23	23	CD
cord-006860-a3b8hyyr	300	19	%	%	NN
cord-006860-a3b8hyyr	300	20	of	of	IN
cord-006860-a3b8hyyr	300	21	non	non	JJ
cord-006860-a3b8hyyr	300	22	fatal	fatal	JJ
cord-006860-a3b8hyyr	300	23	strokes	stroke	NNS
cord-006860-a3b8hyyr	300	24	.	.	.
cord-006860-a3b8hyyr	301	1	The	the	DT
cord-006860-a3b8hyyr	301	2	avoidance	avoidance	NN
cord-006860-a3b8hyyr	301	3	of	of	IN
cord-006860-a3b8hyyr	301	4	nine	nine	CD
cord-006860-a3b8hyyr	301	5	strokes	stroke	NNS
cord-006860-a3b8hyyr	301	6	of	of	IN
cord-006860-a3b8hyyr	301	7	any	any	DT
cord-006860-a3b8hyyr	301	8	cause	cause	NN
cord-006860-a3b8hyyr	301	9	among	among	IN
cord-006860-a3b8hyyr	301	10	the	the	DT
cord-006860-a3b8hyyr	301	11	38	38	CD
cord-006860-a3b8hyyr	301	12	expected	expect	VBN
cord-006860-a3b8hyyr	301	13	in	in	IN
cord-006860-a3b8hyyr	301	14	1000	1000	CD
cord-006860-a3b8hyyr	301	15	patients	patient	NNS
cord-006860-a3b8hyyr	301	16	at	at	IN
cord-006860-a3b8hyyr	301	17	risk	risk	NN
cord-006860-a3b8hyyr	301	18	would	would	MD
cord-006860-a3b8hyyr	301	19	result	result	VB
cord-006860-a3b8hyyr	301	20	from	from	IN
cord-006860-a3b8hyyr	301	21	the	the	DT
cord-006860-a3b8hyyr	301	22	sum	sum	NN
cord-006860-a3b8hyyr	301	23	of	of	IN
cord-006860-a3b8hyyr	301	24	10	10	CD
cord-006860-a3b8hyyr	301	25	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	301	26	events	event	NNS
cord-006860-a3b8hyyr	301	27	avoided	avoid	VBN
cord-006860-a3b8hyyr	301	28	and	and	CC
cord-006860-a3b8hyyr	301	29	a	a	DT
cord-006860-a3b8hyyr	301	30	haemorrhagic	haemorrhagic	JJ
cord-006860-a3b8hyyr	301	31	one	one	NN
cord-006860-a3b8hyyr	301	32	occurred	occur	VBD
cord-006860-a3b8hyyr	301	33	in	in	IN
cord-006860-a3b8hyyr	301	34	excess	excess	NN
cord-006860-a3b8hyyr	301	35	.	.	.
cord-006860-a3b8hyyr	302	1	Ticlopidine	Ticlopidine	NNP
cord-006860-a3b8hyyr	302	2	was	be	VBD
cord-006860-a3b8hyyr	302	3	reported	report	VBN
cord-006860-a3b8hyyr	302	4	to	to	TO
cord-006860-a3b8hyyr	302	5	reduce	reduce	VB
cord-006860-a3b8hyyr	302	6	the	the	DT
cord-006860-a3b8hyyr	302	7	risk	risk	NN
cord-006860-a3b8hyyr	302	8	of	of	IN
cord-006860-a3b8hyyr	302	9	stroke	stroke	NN
cord-006860-a3b8hyyr	302	10	in	in	IN
cord-006860-a3b8hyyr	302	11	two	two	CD
cord-006860-a3b8hyyr	302	12	large	large	JJ
cord-006860-a3b8hyyr	302	13	tdals	tdal	NNS
cord-006860-a3b8hyyr	302	14	(	(	-LRB-
cord-006860-a3b8hyyr	302	15	one	one	CD
cord-006860-a3b8hyyr	302	16	in	in	IN
cord-006860-a3b8hyyr	302	17	patients	patient	NNS
cord-006860-a3b8hyyr	302	18	with	with	IN
cord-006860-a3b8hyyr	302	19	major	major	JJ
cord-006860-a3b8hyyr	302	20	stroke	stroke	NN
cord-006860-a3b8hyyr	302	21	)	)	-RRB-
cord-006860-a3b8hyyr	302	22	,	,	,
cord-006860-a3b8hyyr	302	23	but	but	CC
cord-006860-a3b8hyyr	302	24	there	there	EX
cord-006860-a3b8hyyr	302	25	is	be	VBZ
cord-006860-a3b8hyyr	302	26	no	no	DT
cord-006860-a3b8hyyr	302	27	evidence	evidence	NN
cord-006860-a3b8hyyr	302	28	that	that	IN
cord-006860-a3b8hyyr	302	29	it	-PRON-	PRP
cord-006860-a3b8hyyr	302	30	is	be	VBZ
cord-006860-a3b8hyyr	302	31	better	well	JJR
cord-006860-a3b8hyyr	302	32	or	or	CC
cord-006860-a3b8hyyr	302	33	safer	safe	JJR
cord-006860-a3b8hyyr	302	34	than	than	IN
cord-006860-a3b8hyyr	302	35	aspirin	aspirin	NN
cord-006860-a3b8hyyr	302	36	.	.	.
cord-006860-a3b8hyyr	303	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	303	2	compared	compare	VBD
cord-006860-a3b8hyyr	303	3	the	the	DT
cord-006860-a3b8hyyr	303	4	effect	effect	NN
cord-006860-a3b8hyyr	303	5	of	of	IN
cord-006860-a3b8hyyr	303	6	the	the	DT
cord-006860-a3b8hyyr	303	7	direct	direct	JJ
cord-006860-a3b8hyyr	303	8	specific	specific	JJ
cord-006860-a3b8hyyr	303	9	thrombin	thrombin	NN
cord-006860-a3b8hyyr	303	10	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	303	11	,	,	,
cord-006860-a3b8hyyr	303	12	napsagatran	napsagatran	NNP
cord-006860-a3b8hyyr	303	13	(	(	-LRB-
cord-006860-a3b8hyyr	303	14	NA	NA	NNP
cord-006860-a3b8hyyr	303	15	)	)	-RRB-
cord-006860-a3b8hyyr	303	16	and	and	CC
cord-006860-a3b8hyyr	303	17	rec	rec	NNP
cord-006860-a3b8hyyr	303	18	.	.	.
cord-006860-a3b8hyyr	304	1	hirudin	hirudin	NNP
cord-006860-a3b8hyyr	304	2	(	(	-LRB-
cord-006860-a3b8hyyr	304	3	rH	rH	NNP
cord-006860-a3b8hyyr	304	4	)	)	-RRB-
cord-006860-a3b8hyyr	304	5	with	with	IN
cord-006860-a3b8hyyr	304	6	unfractionated	unfractionated	JJ
cord-006860-a3b8hyyr	304	7	heparin	heparin	NNP
cord-006860-a3b8hyyr	305	1	(	(	-LRB-
cord-006860-a3b8hyyr	305	2	UH	uh	UH
cord-006860-a3b8hyyr	305	3	)	)	-RRB-
cord-006860-a3b8hyyr	305	4	on	on	IN
cord-006860-a3b8hyyr	305	5	the	the	DT
cord-006860-a3b8hyyr	305	6	further	further	JJ
cord-006860-a3b8hyyr	305	7	growth	growth	NN
cord-006860-a3b8hyyr	305	8	of	of	IN
cord-006860-a3b8hyyr	305	9	preformed	preformed	JJ
cord-006860-a3b8hyyr	305	10	thrombi	thrombi	NNP
cord-006860-a3b8hyyr	305	11	.	.	.
cord-006860-a3b8hyyr	306	1	As	as	IN
cord-006860-a3b8hyyr	306	2	a	a	DT
cord-006860-a3b8hyyr	306	3	model	model	NN
cord-006860-a3b8hyyr	306	4	of	of	IN
cord-006860-a3b8hyyr	306	5	thrombogenesls	thrombogenesls	NNP
cord-006860-a3b8hyyr	306	6	,	,	,
cord-006860-a3b8hyyr	306	7	an	an	DT
cord-006860-a3b8hyyr	306	8	annular	annular	JJ
cord-006860-a3b8hyyr	306	9	perfusion	perfusion	NN
cord-006860-a3b8hyyr	306	10	chamber	chamber	NN
cord-006860-a3b8hyyr	306	11	exposing	expose	VBG
cord-006860-a3b8hyyr	306	12	rabbit	rabbit	NN
cord-006860-a3b8hyyr	306	13	aortic	aortic	JJ
cord-006860-a3b8hyyr	306	14	subendothelium	subendothelium	NN
cord-006860-a3b8hyyr	306	15	was	be	VBD
cord-006860-a3b8hyyr	306	16	perfused	perfuse	VBN
cord-006860-a3b8hyyr	306	17	with	with	IN
cord-006860-a3b8hyyr	306	18	native	native	JJ
cord-006860-a3b8hyyr	306	19	rabbit	rabbit	NN
cord-006860-a3b8hyyr	306	20	blood	blood	NN
cord-006860-a3b8hyyr	306	21	at	at	IN
cord-006860-a3b8hyyr	306	22	an	an	DT
cord-006860-a3b8hyyr	306	23	arterial	arterial	JJ
cord-006860-a3b8hyyr	306	24	wall	wall	NN
cord-006860-a3b8hyyr	306	25	shear	shear	NN
cord-006860-a3b8hyyr	306	26	rate	rate	NN
cord-006860-a3b8hyyr	306	27	(	(	-LRB-
cord-006860-a3b8hyyr	306	28	650	650	CD
cord-006860-a3b8hyyr	306	29	/	/	SYM
cord-006860-a3b8hyyr	306	30	s	s	NN
cord-006860-a3b8hyyr	306	31	)	)	-RRB-
cord-006860-a3b8hyyr	306	32	.	.	.
cord-006860-a3b8hyyr	307	1	Fibrin	fibrin	NN
cord-006860-a3b8hyyr	307	2	and	and	CC
cord-006860-a3b8hyyr	307	3	platelet	platelet	NN
cord-006860-a3b8hyyr	307	4	thrombi	thrombi	NNP
cord-006860-a3b8hyyr	307	5	were	be	VBD
cord-006860-a3b8hyyr	307	6	allowed	allow	VBN
cord-006860-a3b8hyyr	307	7	to	to	TO
cord-006860-a3b8hyyr	307	8	form	form	VB
cord-006860-a3b8hyyr	307	9	during	during	IN
cord-006860-a3b8hyyr	307	10	a	a	DT
cord-006860-a3b8hyyr	307	11	10min	10min	JJ
cord-006860-a3b8hyyr	307	12	perfusion	perfusion	NN
cord-006860-a3b8hyyr	307	13	period	period	NN
cord-006860-a3b8hyyr	307	14	after	after	IN
cord-006860-a3b8hyyr	307	15	which	which	WDT
cord-006860-a3b8hyyr	307	16	the	the	DT
cord-006860-a3b8hyyr	307	17	test	test	NN
cord-006860-a3b8hyyr	307	18	agents	agent	NNS
cord-006860-a3b8hyyr	307	19	were	be	VBD
cord-006860-a3b8hyyr	307	20	given	give	VBN
cord-006860-a3b8hyyr	307	21	iv	iv	CD
cord-006860-a3b8hyyr	307	22	as	as	IN
cord-006860-a3b8hyyr	307	23	a	a	DT
cord-006860-a3b8hyyr	307	24	bolus	bolus	NN
cord-006860-a3b8hyyr	307	25	and	and	CC
cord-006860-a3b8hyyr	307	26	a	a	DT
cord-006860-a3b8hyyr	307	27	continuous	continuous	JJ
cord-006860-a3b8hyyr	307	28	infusion	infusion	NN
cord-006860-a3b8hyyr	307	29	(	(	-LRB-
cord-006860-a3b8hyyr	307	30	3	3	CD
cord-006860-a3b8hyyr	307	31	and	and	CC
cord-006860-a3b8hyyr	307	32	10pg	10pg	NNP
cord-006860-a3b8hyyr	307	33	/	/	SYM
cord-006860-a3b8hyyr	307	34	kg	kg	NN
cord-006860-a3b8hyyr	307	35	/	/	SYM
cord-006860-a3b8hyyr	307	36	min	min	NNP
cord-006860-a3b8hyyr	307	37	,	,	,
cord-006860-a3b8hyyr	307	38	n=6	n=6	NNP
cord-006860-a3b8hyyr	307	39	)	)	-RRB-
cord-006860-a3b8hyyr	307	40	and	and	CC
cord-006860-a3b8hyyr	307	41	the	the	DT
cord-006860-a3b8hyyr	307	42	perfusion	perfusion	NN
cord-006860-a3b8hyyr	307	43	continued	continue	VBD
cord-006860-a3b8hyyr	307	44	for	for	IN
cord-006860-a3b8hyyr	307	45	20min	20min	NN
cord-006860-a3b8hyyr	307	46	.	.	.
cord-006860-a3b8hyyr	308	1	The	the	DT
cord-006860-a3b8hyyr	308	2	control	control	NN
cord-006860-a3b8hyyr	308	3	groups	group	NNS
cord-006860-a3b8hyyr	308	4	were	be	VBD
cord-006860-a3b8hyyr	308	5	perfused	perfuse	VBN
cord-006860-a3b8hyyr	308	6	for	for	IN
cord-006860-a3b8hyyr	308	7	10	10	CD
cord-006860-a3b8hyyr	308	8	or	or	CC
cord-006860-a3b8hyyr	308	9	30	30	CD
cord-006860-a3b8hyyr	308	10	rain	rain	NN
cord-006860-a3b8hyyr	308	11	(	(	-LRB-
cord-006860-a3b8hyyr	308	12	n=6	n=6	NN
cord-006860-a3b8hyyr	308	13	)	)	-RRB-
cord-006860-a3b8hyyr	308	14	.	.	.
cord-006860-a3b8hyyr	309	1	Fibrin	fibrin	NN
cord-006860-a3b8hyyr	309	2	deposited	deposit	VBN
cord-006860-a3b8hyyr	309	3	and	and	CC
cord-006860-a3b8hyyr	309	4	platelet	platelet	NN
cord-006860-a3b8hyyr	309	5	thrombi	thrombi	NNP
cord-006860-a3b8hyyr	309	6	formed	form	VBN
cord-006860-a3b8hyyr	309	7	on	on	IN
cord-006860-a3b8hyyr	309	8	subendothelium	subendothelium	NN
cord-006860-a3b8hyyr	309	9	were	be	VBD
cord-006860-a3b8hyyr	309	10	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	309	11	by	by	IN
cord-006860-a3b8hyyr	309	12	microscopic	microscopic	JJ
cord-006860-a3b8hyyr	309	13	morphometry	morphometry	NN
cord-006860-a3b8hyyr	309	14	.	.	.
cord-006860-a3b8hyyr	310	1	The	the	DT
cord-006860-a3b8hyyr	310	2	%	%	NN
cord-006860-a3b8hyyr	310	3	surface	surface	NN
cord-006860-a3b8hyyr	310	4	coverage	coverage	NN
cord-006860-a3b8hyyr	310	5	with	with	IN
cord-006860-a3b8hyyr	310	6	fibrin	fibrin	NN
cord-006860-a3b8hyyr	310	7	was	be	VBD
cord-006860-a3b8hyyr	310	8	not	not	RB
cord-006860-a3b8hyyr	310	9	reduced	reduce	VBN
cord-006860-a3b8hyyr	310	10	in	in	IN
cord-006860-a3b8hyyr	310	11	the	the	DT
cord-006860-a3b8hyyr	310	12	drug	drug	NN
cord-006860-a3b8hyyr	310	13	-	-	HYPH
cord-006860-a3b8hyyr	310	14	treated	treat	VBN
cord-006860-a3b8hyyr	310	15	groups	group	NNS
cord-006860-a3b8hyyr	310	16	since	since	IN
cord-006860-a3b8hyyr	310	17	fibrin	fibrin	NN
cord-006860-a3b8hyyr	310	18	deposition	deposition	NN
cord-006860-a3b8hyyr	310	19	was	be	VBD
cord-006860-a3b8hyyr	310	20	similar	similar	JJ
cord-006860-a3b8hyyr	310	21	in	in	IN
cord-006860-a3b8hyyr	310	22	the	the	DT
cord-006860-a3b8hyyr	310	23	10	10	CD
cord-006860-a3b8hyyr	310	24	and	and	CC
cord-006860-a3b8hyyr	310	25	30	30	CD
cord-006860-a3b8hyyr	310	26	min	min	NN
cord-006860-a3b8hyyr	310	27	control	control	NN
cord-006860-a3b8hyyr	310	28	groups	group	NNS
cord-006860-a3b8hyyr	310	29	(	(	-LRB-
cord-006860-a3b8hyyr	310	30	39	39	CD
cord-006860-a3b8hyyr	310	31	+	+	SYM
cord-006860-a3b8hyyr	310	32	8	8	CD
cord-006860-a3b8hyyr	310	33	%	%	NN
cord-006860-a3b8hyyr	310	34	and	and	CC
cord-006860-a3b8hyyr	310	35	335:6	335:6	CD
cord-006860-a3b8hyyr	310	36	%	%	NN
cord-006860-a3b8hyyr	310	37	,	,	,
cord-006860-a3b8hyyr	310	38	respectively	respectively	RB
cord-006860-a3b8hyyr	310	39	,	,	,
cord-006860-a3b8hyyr	310	40	mean	mean	JJ
cord-006860-a3b8hyyr	310	41	:	:	:
cord-006860-a3b8hyyr	310	42	l	l	NN
cord-006860-a3b8hyyr	310	43	:	:	:
cord-006860-a3b8hyyr	310	44	SEM	SEM	NNP
cord-006860-a3b8hyyr	310	45	)	)	-RRB-
cord-006860-a3b8hyyr	310	46	.	.	.
cord-006860-a3b8hyyr	311	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	311	2	thrombus	thrombus	NN
cord-006860-a3b8hyyr	311	3	area	area	NN
cord-006860-a3b8hyyr	311	4	(	(	-LRB-
cord-006860-a3b8hyyr	311	5	TA	TA	NNP
cord-006860-a3b8hyyr	311	6	)	)	-RRB-
cord-006860-a3b8hyyr	311	7	in	in	IN
cord-006860-a3b8hyyr	311	8	the	the	DT
cord-006860-a3b8hyyr	311	9	control	control	NN
cord-006860-a3b8hyyr	311	10	groups	group	NNS
cord-006860-a3b8hyyr	311	11	increased	increase	VBD
cord-006860-a3b8hyyr	311	12	from	from	IN
cord-006860-a3b8hyyr	311	13	24	24	CD
cord-006860-a3b8hyyr	311	14	+	+	CC
cord-006860-a3b8hyyr	311	15	7pm2	7pm2	CD
cord-006860-a3b8hyyr	311	16	/	/	SYM
cord-006860-a3b8hyyr	311	17	pm	pm	NN
cord-006860-a3b8hyyr	311	18	after	after	IN
cord-006860-a3b8hyyr	311	19	10min	10min	NNP
cord-006860-a3b8hyyr	311	20	to	to	IN
cord-006860-a3b8hyyr	311	21	97	97	CD
cord-006860-a3b8hyyr	311	22	+	+	CD
cord-006860-a3b8hyyr	311	23	32pm2	32pm2	CD
cord-006860-a3b8hyyr	311	24	/	/	SYM
cord-006860-a3b8hyyr	311	25	lim	lim	NNP
cord-006860-a3b8hyyr	311	26	after	after	IN
cord-006860-a3b8hyyr	311	27	30rain	30rain	CD
cord-006860-a3b8hyyr	311	28	perfusion	perfusion	NN
cord-006860-a3b8hyyr	311	29	.	.	.
cord-006860-a3b8hyyr	312	1	NA	NA	NNP
cord-006860-a3b8hyyr	312	2	at	at	IN
cord-006860-a3b8hyyr	312	3	1011g	1011g	CD
cord-006860-a3b8hyyr	312	4	/	/	SYM
cord-006860-a3b8hyyr	312	5	kg	kg	NN
cord-006860-a3b8hyyr	312	6	/	/	SYM
cord-006860-a3b8hyyr	312	7	min	min	NN
cord-006860-a3b8hyyr	312	8	reduced	reduce	VBN
cord-006860-a3b8hyyr	312	9	TA	TA	NNP
cord-006860-a3b8hyyr	312	10	by	by	IN
cord-006860-a3b8hyyr	312	11	94	94	CD
cord-006860-a3b8hyyr	312	12	%	%	NN
cord-006860-a3b8hyyr	312	13	to	to	IN
cord-006860-a3b8hyyr	312	14	values	value	NNS
cord-006860-a3b8hyyr	312	15	(	(	-LRB-
cord-006860-a3b8hyyr	313	1	6+_2ptm2/	6+_2ptm2/	CD
cord-006860-a3b8hyyr	313	2	~m	~m	XX
cord-006860-a3b8hyyr	314	1	)	)	-RRB-
cord-006860-a3b8hyyr	314	2	lower	low	JJR
cord-006860-a3b8hyyr	314	3	than	than	IN
cord-006860-a3b8hyyr	314	4	those	those	DT
cord-006860-a3b8hyyr	314	5	of	of	IN
cord-006860-a3b8hyyr	314	6	the	the	DT
cord-006860-a3b8hyyr	314	7	10min	10min	NNP
cord-006860-a3b8hyyr	314	8	control	control	NN
cord-006860-a3b8hyyr	314	9	group	group	NN
cord-006860-a3b8hyyr	314	10	whereas	whereas	IN
cord-006860-a3b8hyyr	314	11	rH	rH	NNP
cord-006860-a3b8hyyr	314	12	at	at	IN
cord-006860-a3b8hyyr	314	13	this	this	DT
cord-006860-a3b8hyyr	314	14	dose	dose	NN
cord-006860-a3b8hyyr	314	15	reduced	reduce	VBN
cord-006860-a3b8hyyr	314	16	TA	TA	NNP
cord-006860-a3b8hyyr	314	17	by	by	IN
cord-006860-a3b8hyyr	314	18	70	70	CD
cord-006860-a3b8hyyr	314	19	%	%	NN
cord-006860-a3b8hyyr	314	20	(	(	-LRB-
cord-006860-a3b8hyyr	314	21	30-J:141.tm2	30-j:141.tm2	CD
cord-006860-a3b8hyyr	314	22	/	/	SYM
cord-006860-a3b8hyyr	314	23	I.tm	i.tm	CD
cord-006860-a3b8hyyr	314	24	)	)	-RRB-
cord-006860-a3b8hyyr	314	25	.	.	.
cord-006860-a3b8hyyr	315	1	UH	uh	UH
cord-006860-a3b8hyyr	315	2	at	at	IN
cord-006860-a3b8hyyr	315	3	both	both	DT
cord-006860-a3b8hyyr	315	4	doses	dose	NNS
cord-006860-a3b8hyyr	315	5	was	be	VBD
cord-006860-a3b8hyyr	315	6	ineffective	ineffective	JJ
cord-006860-a3b8hyyr	315	7	.	.	.
cord-006860-a3b8hyyr	316	1	These	these	DT
cord-006860-a3b8hyyr	316	2	findings	finding	NNS
cord-006860-a3b8hyyr	316	3	show	show	VBP
cord-006860-a3b8hyyr	316	4	that	that	IN
cord-006860-a3b8hyyr	316	5	in	in	IN
cord-006860-a3b8hyyr	316	6	contrast	contrast	NN
cord-006860-a3b8hyyr	316	7	to	to	IN
cord-006860-a3b8hyyr	316	8	UH	UH	NNP
cord-006860-a3b8hyyr	317	1	the	the	DT
cord-006860-a3b8hyyr	317	2	direct	direct	JJ
cord-006860-a3b8hyyr	317	3	thrombin	thrombin	NN
cord-006860-a3b8hyyr	317	4	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	317	5	NA	NA	NNP
cord-006860-a3b8hyyr	317	6	and	and	CC
cord-006860-a3b8hyyr	317	7	rH	rH	NNP
cord-006860-a3b8hyyr	317	8	inhibit	inhibit	VBP
cord-006860-a3b8hyyr	317	9	the	the	DT
cord-006860-a3b8hyyr	317	10	growth	growth	NN
cord-006860-a3b8hyyr	317	11	of	of	IN
cord-006860-a3b8hyyr	317	12	preexisting	preexist	VBG
cord-006860-a3b8hyyr	317	13	thrombi	thrombi	NN
cord-006860-a3b8hyyr	317	14	.	.	.
cord-006860-a3b8hyyr	318	1	These	these	DT
cord-006860-a3b8hyyr	318	2	results	result	NNS
cord-006860-a3b8hyyr	318	3	could	could	MD
cord-006860-a3b8hyyr	318	4	be	be	VB
cord-006860-a3b8hyyr	318	5	explained	explain	VBN
cord-006860-a3b8hyyr	318	6	by	by	IN
cord-006860-a3b8hyyr	318	7	the	the	DT
cord-006860-a3b8hyyr	318	8	higher	high	JJR
cord-006860-a3b8hyyr	318	9	potency	potency	NN
cord-006860-a3b8hyyr	318	10	of	of	IN
cord-006860-a3b8hyyr	318	11	NA	NA	NNP
cord-006860-a3b8hyyr	318	12	and	and	CC
cord-006860-a3b8hyyr	318	13	rH	rH	NNP
cord-006860-a3b8hyyr	318	14	as	as	IN
cord-006860-a3b8hyyr	318	15	compared	compare	VBN
cord-006860-a3b8hyyr	318	16	to	to	IN
cord-006860-a3b8hyyr	318	17	UH	UH	NNP
cord-006860-a3b8hyyr	318	18	for	for	IN
cord-006860-a3b8hyyr	318	19	inhibiting	inhibit	VBG
cord-006860-a3b8hyyr	319	1	clotbound	clotbound	NNP
cord-006860-a3b8hyyr	319	2	thrombin	thrombin	NNP
cord-006860-a3b8hyyr	320	1	(	(	-LRB-
cord-006860-a3b8hyyr	320	2	Gast	Gast	NNP
cord-006860-a3b8hyyr	320	3	et	et	FW
cord-006860-a3b8hyyr	320	4	al	al	NNP
cord-006860-a3b8hyyr	320	5	.	.	NNP
cord-006860-a3b8hyyr	320	6	,	,	,
cord-006860-a3b8hyyr	321	1	Blood	blood	NN
cord-006860-a3b8hyyr	321	2	Coagul	Coagul	NNP
cord-006860-a3b8hyyr	321	3	Fibrinol	Fibrinol	NNP
cord-006860-a3b8hyyr	321	4	1994	1994	CD
cord-006860-a3b8hyyr	321	5	,	,	,
cord-006860-a3b8hyyr	321	6	5	5	CD
cord-006860-a3b8hyyr	321	7	.	.	.
cord-006860-a3b8hyyr	321	8	'	'	''
cord-006860-a3b8hyyr	322	1	879	879	CD
cord-006860-a3b8hyyr	322	2	-	-	CD
cord-006860-a3b8hyyr	322	3	87	87	CD
cord-006860-a3b8hyyr	322	4	)	)	-RRB-
cord-006860-a3b8hyyr	323	1	and	and	CC
cord-006860-a3b8hyyr	323	2	suggest	suggest	VBP
cord-006860-a3b8hyyr	323	3	that	that	IN
cord-006860-a3b8hyyr	323	4	thrombus	thrombus	NN
cord-006860-a3b8hyyr	323	5	-	-	HYPH
cord-006860-a3b8hyyr	323	6	bound	bind	VBN
cord-006860-a3b8hyyr	323	7	thrombin	thrombin	NN
cord-006860-a3b8hyyr	323	8	is	be	VBZ
cord-006860-a3b8hyyr	323	9	an	an	DT
cord-006860-a3b8hyyr	323	10	important	important	JJ
cord-006860-a3b8hyyr	323	11	modulator	modulator	NN
cord-006860-a3b8hyyr	323	12	of	of	IN
cord-006860-a3b8hyyr	323	13	platelet	platelet	NN
cord-006860-a3b8hyyr	323	14	thrombus	thrombus	NN
cord-006860-a3b8hyyr	323	15	growth	growth	NN
cord-006860-a3b8hyyr	323	16	and/or	and/or	CC
cord-006860-a3b8hyyr	323	17	stability	stability	NN
cord-006860-a3b8hyyr	323	18	in	in	IN
cord-006860-a3b8hyyr	323	19	this	this	DT
cord-006860-a3b8hyyr	323	20	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	323	21	model	model	NN
cord-006860-a3b8hyyr	323	22	.	.	.
cord-006860-a3b8hyyr	324	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	324	2	adhesion	adhesion	NN
cord-006860-a3b8hyyr	324	3	-the	-the	ADD
cord-006860-a3b8hyyr	324	4	initial	initial	JJ
cord-006860-a3b8hyyr	324	5	event	event	NN
cord-006860-a3b8hyyr	324	6	of	of	IN
cord-006860-a3b8hyyr	324	7	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	324	8	-is	-is	:
cord-006860-a3b8hyyr	324	9	believed	believe	VBN
cord-006860-a3b8hyyr	324	10	to	to	TO
cord-006860-a3b8hyyr	324	11	be	be	VB
cord-006860-a3b8hyyr	324	12	completely	completely	RB
cord-006860-a3b8hyyr	324	13	prevented	prevent	VBN
cord-006860-a3b8hyyr	324	14	by	by	IN
cord-006860-a3b8hyyr	324	15	intact	intact	JJ
cord-006860-a3b8hyyr	324	16	endothelium	endothelium	NN
cord-006860-a3b8hyyr	324	17	.	.	.
cord-006860-a3b8hyyr	325	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	325	2	challenged	challenge	VBD
cord-006860-a3b8hyyr	325	3	this	this	DT
cord-006860-a3b8hyyr	325	4	theory	theory	NN
cord-006860-a3b8hyyr	325	5	by	by	IN
cord-006860-a3b8hyyr	325	6	superfusing	superfuse	VBG
cord-006860-a3b8hyyr	325	7	intact	intact	JJ
cord-006860-a3b8hyyr	325	8	human	human	JJ
cord-006860-a3b8hyyr	325	9	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	325	10	vein	vein	NN
cord-006860-a3b8hyyr	325	11	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	325	12	monolayers	monolayer	NNS
cord-006860-a3b8hyyr	325	13	with	with	IN
cord-006860-a3b8hyyr	325	14	activated	activate	VBN
cord-006860-a3b8hyyr	325	15	human	human	JJ
cord-006860-a3b8hyyr	325	16	platelet	platelet	NN
cord-006860-a3b8hyyr	325	17	rich	rich	JJ
cord-006860-a3b8hyyr	325	18	plasma	plasma	NN
cord-006860-a3b8hyyr	325	19	utilizing	utilize	VBG
cord-006860-a3b8hyyr	325	20	the	the	DT
cord-006860-a3b8hyyr	325	21	Stagnation	Stagnation	NNP
cord-006860-a3b8hyyr	325	22	Point	Point	NNP
cord-006860-a3b8hyyr	325	23	Flow	Flow	NNP
cord-006860-a3b8hyyr	325	24	Adhesio	Adhesio	NNP
cord-006860-a3b8hyyr	325	25	-	-	HYPH
cord-006860-a3b8hyyr	325	26	Aggregometer	Aggregometer	NNP
cord-006860-a3b8hyyr	325	27	(	(	-LRB-
cord-006860-a3b8hyyr	325	28	SPAA	SPAA	NNP
cord-006860-a3b8hyyr	325	29	)	)	-RRB-
cord-006860-a3b8hyyr	325	30	.	.	.
cord-006860-a3b8hyyr	326	1	The	the	DT
cord-006860-a3b8hyyr	326	2	SPAA	SPAA	NNP
cord-006860-a3b8hyyr	326	3	provides	provide	VBZ
cord-006860-a3b8hyyr	326	4	flow	flow	NN
cord-006860-a3b8hyyr	326	5	mediated	mediate	VBN
cord-006860-a3b8hyyr	326	6	contact	contact	NN
cord-006860-a3b8hyyr	326	7	of	of	IN
cord-006860-a3b8hyyr	326	8	platelets	platelet	NNS
cord-006860-a3b8hyyr	326	9	with	with	IN
cord-006860-a3b8hyyr	326	10	the	the	DT
cord-006860-a3b8hyyr	326	11	superfused	superfused	JJ
cord-006860-a3b8hyyr	326	12	surface	surface	NN
cord-006860-a3b8hyyr	326	13	.	.	.
cord-006860-a3b8hyyr	327	1	Heparinized	Heparinized	NNP
cord-006860-a3b8hyyr	327	2	(	(	-LRB-
cord-006860-a3b8hyyr	327	3	3.5	3.5	CD
cord-006860-a3b8hyyr	327	4	-4.0	-4.0	NNP
cord-006860-a3b8hyyr	327	5	U	U	NNP
cord-006860-a3b8hyyr	327	6	/	/	SYM
cord-006860-a3b8hyyr	327	7	ml	ml	NN
cord-006860-a3b8hyyr	327	8	)	)	-RRB-
cord-006860-a3b8hyyr	327	9	platelet	platelet	JJ
cord-006860-a3b8hyyr	327	10	rich	rich	JJ
cord-006860-a3b8hyyr	327	11	plasma	plasma	NN
cord-006860-a3b8hyyr	327	12	(	(	-LRB-
cord-006860-a3b8hyyr	327	13	PRP	prp	NN
cord-006860-a3b8hyyr	327	14	)	)	-RRB-
cord-006860-a3b8hyyr	327	15	was	be	VBD
cord-006860-a3b8hyyr	327	16	obtained	obtain	VBN
cord-006860-a3b8hyyr	327	17	from	from	IN
cord-006860-a3b8hyyr	327	18	healthy	healthy	JJ
cord-006860-a3b8hyyr	327	19	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	327	20	and	and	CC
cord-006860-a3b8hyyr	327	21	activated	activate	VBN
cord-006860-a3b8hyyr	327	22	by	by	IN
cord-006860-a3b8hyyr	327	23	addition	addition	NN
cord-006860-a3b8hyyr	327	24	of	of	IN
cord-006860-a3b8hyyr	327	25	adenosine	adenosine	NN
cord-006860-a3b8hyyr	327	26	diphosphate	diphosphate	NN
cord-006860-a3b8hyyr	327	27	(	(	-LRB-
cord-006860-a3b8hyyr	327	28	ADP	ADP	NNP
cord-006860-a3b8hyyr	327	29	2"10	2"10	CD
cord-006860-a3b8hyyr	327	30	-6	-6	NNP
cord-006860-a3b8hyyr	327	31	M	M	NNP
cord-006860-a3b8hyyr	327	32	)	)	-RRB-
cord-006860-a3b8hyyr	327	33	.	.	.
cord-006860-a3b8hyyr	328	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	328	2	deposition	deposition	NN
cord-006860-a3b8hyyr	328	3	was	be	VBD
cord-006860-a3b8hyyr	328	4	recorded	record	VBN
cord-006860-a3b8hyyr	328	5	on	on	IN
cord-006860-a3b8hyyr	328	6	-	-	HYPH
cord-006860-a3b8hyyr	328	7	line	line	NN
cord-006860-a3b8hyyr	328	8	by	by	IN
cord-006860-a3b8hyyr	328	9	video	video	NN
cord-006860-a3b8hyyr	328	10	as	as	RB
cord-006860-a3b8hyyr	328	11	well	well	RB
cord-006860-a3b8hyyr	328	12	as	as	IN
cord-006860-a3b8hyyr	328	13	by	by	IN
cord-006860-a3b8hyyr	328	14	measuring	measure	VBG
cord-006860-a3b8hyyr	328	15	scattered	scatter	VBN
cord-006860-a3b8hyyr	328	16	light	light	NN
cord-006860-a3b8hyyr	328	17	.	.	.
cord-006860-a3b8hyyr	329	1	Fixed	fix	VBN
cord-006860-a3b8hyyr	329	2	samples	sample	NNS
cord-006860-a3b8hyyr	329	3	were	be	VBD
cord-006860-a3b8hyyr	329	4	examined	examine	VBN
cord-006860-a3b8hyyr	329	5	by	by	IN
cord-006860-a3b8hyyr	329	6	phase	phase	NN
cord-006860-a3b8hyyr	329	7	contrast	contrast	NN
cord-006860-a3b8hyyr	329	8	and	and	CC
cord-006860-a3b8hyyr	329	9	electron	electron	NN
cord-006860-a3b8hyyr	329	10	microscopy	microscopy	NN
cord-006860-a3b8hyyr	329	11	,	,	,
cord-006860-a3b8hyyr	329	12	Inhibition	inhibition	NN
cord-006860-a3b8hyyr	329	13	experiments	experiment	NNS
cord-006860-a3b8hyyr	329	14	were	be	VBD
cord-006860-a3b8hyyr	329	15	performed	perform	VBN
cord-006860-a3b8hyyr	329	16	with	with	IN
cord-006860-a3b8hyyr	329	17	either	either	CC
cord-006860-a3b8hyyr	329	18	the	the	DT
cord-006860-a3b8hyyr	329	19	tetrapeptide	tetrapeptide	NN
cord-006860-a3b8hyyr	329	20	RGDS	RGDS	NNP
cord-006860-a3b8hyyr	329	21	,	,	,
cord-006860-a3b8hyyr	329	22	the	the	DT
cord-006860-a3b8hyyr	329	23	non	non	JJ
cord-006860-a3b8hyyr	329	24	-	-	JJ
cord-006860-a3b8hyyr	329	25	peptide	peptide	JJ
cord-006860-a3b8hyyr	329	26	GPIIb	GPIIb	NNS
cord-006860-a3b8hyyr	329	27	/	/	SYM
cord-006860-a3b8hyyr	329	28	llla	llla	NN
cord-006860-a3b8hyyr	329	29	-	-	HYPH
cord-006860-a3b8hyyr	329	30	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	329	31	Ro-43	Ro-43	NNP
cord-006860-a3b8hyyr	329	32	-	-	HYPH
cord-006860-a3b8hyyr	329	33	8857	8857	CD
cord-006860-a3b8hyyr	329	34	or	or	CC
cord-006860-a3b8hyyr	329	35	a	a	DT
cord-006860-a3b8hyyr	329	36	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	329	37	antibody	antibody	NN
cord-006860-a3b8hyyr	329	38	directed	direct	VBN
cord-006860-a3b8hyyr	329	39	against	against	IN
cord-006860-a3b8hyyr	329	40	the	the	DT
cord-006860-a3b8hyyr	329	41	GPIlb	GPIlb	NNP
cord-006860-a3b8hyyr	329	42	/	/	SYM
cord-006860-a3b8hyyr	329	43	llla	llla	NNP
cord-006860-a3b8hyyr	329	44	complex	complex	NN
cord-006860-a3b8hyyr	329	45	.	.	.
cord-006860-a3b8hyyr	330	1	Stimulation	stimulation	NN
cord-006860-a3b8hyyr	330	2	with	with	IN
cord-006860-a3b8hyyr	330	3	ADP	ADP	NNP
cord-006860-a3b8hyyr	330	4	prompted	prompt	VBD
cord-006860-a3b8hyyr	330	5	platelets	platelet	NNS
cord-006860-a3b8hyyr	330	6	to	to	TO
cord-006860-a3b8hyyr	330	7	adhere	adhere	VB
cord-006860-a3b8hyyr	330	8	to	to	IN
cord-006860-a3b8hyyr	330	9	intact	intact	JJ
cord-006860-a3b8hyyr	330	10	endothelium	endothelium	VB
cord-006860-a3b8hyyr	330	11	single	single	JJ
cord-006860-a3b8hyyr	330	12	or	or	CC
cord-006860-a3b8hyyr	330	13	as	as	IN
cord-006860-a3b8hyyr	330	14	microaggregates	microaggregates	NNP
cord-006860-a3b8hyyr	330	15	of	of	IN
cord-006860-a3b8hyyr	330	16	a	a	DT
cord-006860-a3b8hyyr	330	17	diameter	diameter	NN
cord-006860-a3b8hyyr	330	18	of	of	IN
cord-006860-a3b8hyyr	330	19	up	up	IN
cord-006860-a3b8hyyr	330	20	to	to	TO
cord-006860-a3b8hyyr	330	21	100	100	CD
cord-006860-a3b8hyyr	330	22	micrometer	micrometer	NN
cord-006860-a3b8hyyr	330	23	.	.	.
cord-006860-a3b8hyyr	331	1	Adhesion	adhesion	NN
cord-006860-a3b8hyyr	331	2	was	be	VBD
cord-006860-a3b8hyyr	331	3	dependent	dependent	JJ
cord-006860-a3b8hyyr	331	4	upon	upon	IN
cord-006860-a3b8hyyr	331	5	convective	convective	JJ
cord-006860-a3b8hyyr	331	6	transport	transport	NN
cord-006860-a3b8hyyr	331	7	resulting	result	VBG
cord-006860-a3b8hyyr	331	8	in	in	IN
cord-006860-a3b8hyyr	331	9	platelet	platelet	NN
cord-006860-a3b8hyyr	331	10	collision	collision	NN
cord-006860-a3b8hyyr	331	11	with	with	IN
cord-006860-a3b8hyyr	331	12	the	the	DT
cord-006860-a3b8hyyr	331	13	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	331	14	monolayer	monolayer	NN
cord-006860-a3b8hyyr	331	15	.	.	.
cord-006860-a3b8hyyr	332	1	Infusion	infusion	NN
cord-006860-a3b8hyyr	332	2	of	of	IN
cord-006860-a3b8hyyr	332	3	RGDS	RGDS	NNP
cord-006860-a3b8hyyr	332	4	or	or	CC
cord-006860-a3b8hyyr	332	5	Ro-43	Ro-43	NNP
cord-006860-a3b8hyyr	332	6	-	-	HYPH
cord-006860-a3b8hyyr	332	7	8857	8857	CD
cord-006860-a3b8hyyr	332	8	into	into	IN
cord-006860-a3b8hyyr	332	9	the	the	DT
cord-006860-a3b8hyyr	332	10	flowing	flow	VBG
cord-006860-a3b8hyyr	332	11	,	,	,
cord-006860-a3b8hyyr	332	12	ADP	ADP	NNP
cord-006860-a3b8hyyr	332	13	-	-	HYPH
cord-006860-a3b8hyyr	332	14	stimulated	stimulate	VBN
cord-006860-a3b8hyyr	332	15	PRP	PRP	NNP
cord-006860-a3b8hyyr	332	16	completely	completely	RB
cord-006860-a3b8hyyr	332	17	prevented	prevent	VBD
cord-006860-a3b8hyyr	332	18	platelet	platelet	NN
cord-006860-a3b8hyyr	332	19	adhesion	adhesion	NN
cord-006860-a3b8hyyr	332	20	to	to	IN
cord-006860-a3b8hyyr	332	21	the	the	DT
cord-006860-a3b8hyyr	332	22	endothelium	endothelium	NN
cord-006860-a3b8hyyr	332	23	as	as	RB
cord-006860-a3b8hyyr	332	24	well	well	RB
cord-006860-a3b8hyyr	332	25	as	as	IN
cord-006860-a3b8hyyr	332	26	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	332	27	aggregation	aggregation	NN
cord-006860-a3b8hyyr	332	28	.	.	.
cord-006860-a3b8hyyr	333	1	When	when	WRB
cord-006860-a3b8hyyr	333	2	the	the	DT
cord-006860-a3b8hyyr	333	3	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	333	4	inflow	inflow	NN
cord-006860-a3b8hyyr	333	5	was	be	VBD
cord-006860-a3b8hyyr	333	6	stopped	stop	VBN
cord-006860-a3b8hyyr	333	7	while	while	IN
cord-006860-a3b8hyyr	333	8	ADP	ADP	NNP
cord-006860-a3b8hyyr	333	9	stimulation	stimulation	NN
cord-006860-a3b8hyyr	333	10	persisted	persist	VBD
cord-006860-a3b8hyyr	333	11	,	,	,
cord-006860-a3b8hyyr	333	12	adhesion	adhesion	NN
cord-006860-a3b8hyyr	333	13	and	and	CC
cord-006860-a3b8hyyr	333	14	aggregation	aggregation	NN
cord-006860-a3b8hyyr	333	15	occurred	occur	VBD
cord-006860-a3b8hyyr	333	16	immediately	immediately	RB
cord-006860-a3b8hyyr	333	17	.	.	.
cord-006860-a3b8hyyr	334	1	Re	Re	VBG
cord-006860-a3b8hyyr	334	2	-	-	VBG
cord-006860-a3b8hyyr	334	3	establishing	establish	VBG
cord-006860-a3b8hyyr	334	4	the	the	DT
cord-006860-a3b8hyyr	334	5	inflow	inflow	NN
cord-006860-a3b8hyyr	334	6	of	of	IN
cord-006860-a3b8hyyr	334	7	the	the	DT
cord-006860-a3b8hyyr	334	8	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	334	9	-with	-with	:
cord-006860-a3b8hyyr	334	10	still	still	RB
cord-006860-a3b8hyyr	334	11	continued	continue	VBD
cord-006860-a3b8hyyr	334	12	ADP	adp	JJ
cord-006860-a3b8hyyr	334	13	stimulation	stimulation	NN
cord-006860-a3b8hyyr	334	14	-led	-led	''
cord-006860-a3b8hyyr	334	15	to	to	IN
cord-006860-a3b8hyyr	334	16	disintegration	disintegration	NN
cord-006860-a3b8hyyr	334	17	of	of	IN
cord-006860-a3b8hyyr	334	18	the	the	DT
cord-006860-a3b8hyyr	334	19	adhering	adhere	VBG
cord-006860-a3b8hyyr	334	20	aggregates	aggregate	NNS
cord-006860-a3b8hyyr	334	21	.	.	.
cord-006860-a3b8hyyr	335	1	When	when	WRB
cord-006860-a3b8hyyr	335	2	PRP	PRP	NNP
cord-006860-a3b8hyyr	335	3	preincubated	preincubate	VBN
cord-006860-a3b8hyyr	335	4	with	with	IN
cord-006860-a3b8hyyr	335	5	the	the	DT
cord-006860-a3b8hyyr	335	6	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	335	7	antibody	antibody	NN
cord-006860-a3b8hyyr	335	8	against	against	IN
cord-006860-a3b8hyyr	335	9	GPllb	GPllb	NNP
cord-006860-a3b8hyyr	335	10	/	/	SYM
cord-006860-a3b8hyyr	335	11	llla	llla	NNP
cord-006860-a3b8hyyr	335	12	was	be	VBD
cord-006860-a3b8hyyr	335	13	superfused	superfused	JJ
cord-006860-a3b8hyyr	335	14	,	,	,
cord-006860-a3b8hyyr	335	15	platelet	platelet	NN
cord-006860-a3b8hyyr	335	16	adhesion	adhesion	NN
cord-006860-a3b8hyyr	335	17	to	to	IN
cord-006860-a3b8hyyr	335	18	the	the	DT
cord-006860-a3b8hyyr	335	19	endothelium	endothelium	NN
cord-006860-a3b8hyyr	335	20	and	and	CC
cord-006860-a3b8hyyr	335	21	aggregation	aggregation	NN
cord-006860-a3b8hyyr	335	22	were	be	VBD
cord-006860-a3b8hyyr	335	23	irreversibly	irreversibly	RB
cord-006860-a3b8hyyr	335	24	blocked	block	VBN
cord-006860-a3b8hyyr	335	25	.	.	.
cord-006860-a3b8hyyr	336	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	336	2	results	result	NNS
cord-006860-a3b8hyyr	336	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	336	4	that	that	IN
cord-006860-a3b8hyyr	336	5	convective	convective	JJ
cord-006860-a3b8hyyr	336	6	transport	transport	NN
cord-006860-a3b8hyyr	336	7	and	and	CC
cord-006860-a3b8hyyr	336	8	stimulation	stimulation	NN
cord-006860-a3b8hyyr	336	9	of	of	IN
cord-006860-a3b8hyyr	336	10	platelets	platelet	NNS
cord-006860-a3b8hyyr	336	11	are	be	VBP
cord-006860-a3b8hyyr	336	12	prerequisites	prerequisite	NNS
cord-006860-a3b8hyyr	336	13	to	to	TO
cord-006860-a3b8hyyr	336	14	overcome	overcome	VB
cord-006860-a3b8hyyr	336	15	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	336	16	thromboresistance	thromboresistance	NN
cord-006860-a3b8hyyr	336	17	and	and	CC
cord-006860-a3b8hyyr	336	18	that	that	IN
cord-006860-a3b8hyyr	336	19	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	336	20	platelet	platelet	NN
cord-006860-a3b8hyyr	336	21	adhesion	adhesion	NN
cord-006860-a3b8hyyr	336	22	to	to	IN
cord-006860-a3b8hyyr	336	23	the	the	DT
cord-006860-a3b8hyyr	336	24	endothelium	endothelium	NN
cord-006860-a3b8hyyr	336	25	is	be	VBZ
cord-006860-a3b8hyyr	336	26	mediated	mediate	VBN
cord-006860-a3b8hyyr	336	27	via	via	IN
cord-006860-a3b8hyyr	336	28	the	the	DT
cord-006860-a3b8hyyr	336	29	platelet	platelet	NN
cord-006860-a3b8hyyr	336	30	GPIlb	GPIlb	NNP
cord-006860-a3b8hyyr	336	31	/	/	SYM
cord-006860-a3b8hyyr	336	32	llla	llla	NNP
cord-006860-a3b8hyyr	336	33	receptor	receptor	NN
cord-006860-a3b8hyyr	336	34	complex	complex	NN
cord-006860-a3b8hyyr	336	35	.	.	.
cord-006860-a3b8hyyr	337	1	PREVENT	prevent	JJ
cord-006860-a3b8hyyr	337	2	THROMBUS	THROMBUS	NNP
cord-006860-a3b8hyyr	337	3	FORMATION	formation	NN
cord-006860-a3b8hyyr	337	4	AFFER	AFFER	NNP
cord-006860-a3b8hyyr	338	1	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	339	1	I.P.	I.P.	NNP
cord-006860-a3b8hyyr	339	2	8tepanova	8tepanova	CD
cord-006860-a3b8hyyr	339	3	t	t	NN
cord-006860-a3b8hyyr	339	4	,	,	,
cord-006860-a3b8hyyr	339	5	G.V.	G.V.	NNP
cord-006860-a3b8hyyr	339	6	Bashkov	Bashkov	NNP
cord-006860-a3b8hyyr	339	7	2	2	CD
cord-006860-a3b8hyyr	339	8	,	,	,
cord-006860-a3b8hyyr	339	9	l.	l.	NNP
cord-006860-a3b8hyyr	340	1	P.Kapralova	P.Kapralova	NNP
cord-006860-a3b8hyyr	341	1	,	,	,
cord-006860-a3b8hyyr	341	2	2	2	CD
cord-006860-a3b8hyyr	341	3	S.P.	S.P.	NNP
cord-006860-a3b8hyyr	341	4	Domogatsky	Domogatsky	NNP
cord-006860-a3b8hyyr	341	5	~	~	NFP
cord-006860-a3b8hyyr	341	6	Cardiology	Cardiology	NNP
cord-006860-a3b8hyyr	341	7	Research	Research	NNP
cord-006860-a3b8hyyr	341	8	Center	Center	NNP
cord-006860-a3b8hyyr	341	9	t	t	NNP
cord-006860-a3b8hyyr	341	10	and	and	CC
cord-006860-a3b8hyyr	341	11	National	National	NNP
cord-006860-a3b8hyyr	341	12	Haematology	Haematology	NNP
cord-006860-a3b8hyyr	341	13	Scientific	Scientific	NNP
cord-006860-a3b8hyyr	341	14	Cettter	Cettter	NNP
cord-006860-a3b8hyyr	341	15	2	2	CD
cord-006860-a3b8hyyr	341	16	Russian	Russian	NNP
cord-006860-a3b8hyyr	341	17	Academy	Academy	NNP
cord-006860-a3b8hyyr	341	18	of	of	IN
cord-006860-a3b8hyyr	341	19	Medical	Medical	NNP
cord-006860-a3b8hyyr	341	20	Sciences	Sciences	NNPS
cord-006860-a3b8hyyr	341	21	,	,	,
cord-006860-a3b8hyyr	341	22	Moscow	Moscow	NNP
cord-006860-a3b8hyyr	341	23	,	,	,
cord-006860-a3b8hyyr	341	24	Russia	Russia	NNP
cord-006860-a3b8hyyr	341	25	Percutaneous	Percutaneous	NNP
cord-006860-a3b8hyyr	342	1	transluminal	transluminal	NNP
cord-006860-a3b8hyyr	342	2	coronary	coronary	NNP
cord-006860-a3b8hyyr	342	3	angioplasty	angioplasty	NNP
cord-006860-a3b8hyyr	342	4	(	(	-LRB-
cord-006860-a3b8hyyr	342	5	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	342	6	)	)	-RRB-
cord-006860-a3b8hyyr	342	7	results	result	VBZ
cord-006860-a3b8hyyr	342	8	in	in	IN
cord-006860-a3b8hyyr	342	9	atheroselerotie	atheroselerotie	NN
cord-006860-a3b8hyyr	342	10	plague	plague	NN
cord-006860-a3b8hyyr	342	11	rapture	rapture	NN
cord-006860-a3b8hyyr	342	12	,	,	,
cord-006860-a3b8hyyr	342	13	vascular	vascular	JJ
cord-006860-a3b8hyyr	342	14	wall	wall	NN
cord-006860-a3b8hyyr	342	15	damage	damage	NN
cord-006860-a3b8hyyr	342	16	and	and	CC
cord-006860-a3b8hyyr	342	17	thrombogenic	thrombogenic	NNP
cord-006860-a3b8hyyr	342	18	collagen	collagen	NN
cord-006860-a3b8hyyr	342	19	exposure	exposure	NN
cord-006860-a3b8hyyr	342	20	.	.	.
cord-006860-a3b8hyyr	343	1	Subendothelial	subendothelial	JJ
cord-006860-a3b8hyyr	343	2	collagen	collagen	NN
cord-006860-a3b8hyyr	343	3	type	type	NN
cord-006860-a3b8hyyr	343	4	I	I	NNP
cord-006860-a3b8hyyr	343	5	-	-	HYPH
cord-006860-a3b8hyyr	343	6	lll	lll	NNP
cord-006860-a3b8hyyr	343	7	is	be	VBZ
cord-006860-a3b8hyyr	343	8	a	a	DT
cord-006860-a3b8hyyr	343	9	very	very	RB
cord-006860-a3b8hyyr	343	10	~rong	~rong	CD
cord-006860-a3b8hyyr	343	11	agonist	agonist	NN
cord-006860-a3b8hyyr	343	12	of	of	IN
cord-006860-a3b8hyyr	343	13	platelet	platelet	NN
cord-006860-a3b8hyyr	343	14	-	-	HYPH
cord-006860-a3b8hyyr	343	15	dependent	dependent	JJ
cord-006860-a3b8hyyr	343	16	thrombus	thrombus	NN
cord-006860-a3b8hyyr	343	17	formation	formation	NN
cord-006860-a3b8hyyr	343	18	in	in	IN
cord-006860-a3b8hyyr	343	19	arteries	artery	NNS
cord-006860-a3b8hyyr	343	20	.	.	.
cord-006860-a3b8hyyr	344	1	The	the	DT
cord-006860-a3b8hyyr	344	2	anlithrombotic	anlithrombotic	JJ
cord-006860-a3b8hyyr	344	3	action	action	NN
cord-006860-a3b8hyyr	344	4	of	of	IN
cord-006860-a3b8hyyr	344	5	rabbit	rabbit	NN
cord-006860-a3b8hyyr	344	6	polyclonal	polyclonal	JJ
cord-006860-a3b8hyyr	344	7	antibodies	antibody	NNS
cord-006860-a3b8hyyr	344	8	to	to	IN
cord-006860-a3b8hyyr	344	9	rat	rat	NN
cord-006860-a3b8hyyr	344	10	collagen	collagen	NN
cord-006860-a3b8hyyr	344	11	type	type	NN
cord-006860-a3b8hyyr	344	12	I	I	NNP
cord-006860-a3b8hyyr	344	13	-	-	HYPH
cord-006860-a3b8hyyr	344	14	ill	ill	JJ
cord-006860-a3b8hyyr	344	15	and	and	CC
cord-006860-a3b8hyyr	344	16	their	-PRON-	PRP$
cord-006860-a3b8hyyr	344	17	chemically	chemically	RB
cord-006860-a3b8hyyr	344	18	synthetized	synthetize	VBN
cord-006860-a3b8hyyr	344	19	conjugate	conjugate	NN
cord-006860-a3b8hyyr	344	20	with	with	IN
cord-006860-a3b8hyyr	344	21	monoclonals	monoclonal	NNS
cord-006860-a3b8hyyr	344	22	to	to	IN
cord-006860-a3b8hyyr	344	23	human	human	JJ
cord-006860-a3b8hyyr	344	24	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	344	25	two	two	CD
cord-006860-a3b8hyyr	344	26	-	-	HYPH
cord-006860-a3b8hyyr	344	27	chain	chain	NN
cord-006860-a3b8hyyr	344	28	/	/	SYM
cord-006860-a3b8hyyr	344	29	one	one	CD
cord-006860-a3b8hyyr	344	30	-	-	HYPH
cord-006860-a3b8hyyr	344	31	chain	chain	NN
cord-006860-a3b8hyyr	344	32	urokinase	urokinase	NN
cord-006860-a3b8hyyr	344	33	type	type	NN
cord-006860-a3b8hyyr	344	34	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	344	35	activator	activator	NN
cord-006860-a3b8hyyr	344	36	(	(	-LRB-
cord-006860-a3b8hyyr	344	37	rtcu	rtcu	NNP
cord-006860-a3b8hyyr	344	38	-	-	HYPH
cord-006860-a3b8hyyr	344	39	PA	PA	NNP
cord-006860-a3b8hyyr	344	40	/	/	SYM
cord-006860-a3b8hyyr	344	41	rseu	rseu	NNP
cord-006860-a3b8hyyr	344	42	-	-	HYPH
cord-006860-a3b8hyyr	344	43	PA	PA	NNP
cord-006860-a3b8hyyr	344	44	)	)	-RRB-
cord-006860-a3b8hyyr	344	45	,	,	,
cord-006860-a3b8hyyr	344	46	cross	cross	VBP
cord-006860-a3b8hyyr	344	47	reacting	react	VBG
cord-006860-a3b8hyyr	344	48	with	with	IN
cord-006860-a3b8hyyr	344	49	rat	rat	NNP
cord-006860-a3b8hyyr	344	50	tcu	tcu	NNP
cord-006860-a3b8hyyr	344	51	-	-	HYPH
cord-006860-a3b8hyyr	344	52	PA	PA	NNP
cord-006860-a3b8hyyr	344	53	/	/	SYM
cord-006860-a3b8hyyr	344	54	scu	scu	NNP
cord-006860-a3b8hyyr	344	55	-	-	HYPH
cord-006860-a3b8hyyr	344	56	PA	PA	NNP
cord-006860-a3b8hyyr	344	57	was	be	VBD
cord-006860-a3b8hyyr	344	58	studied	study	VBN
cord-006860-a3b8hyyr	344	59	both	both	CC
cord-006860-a3b8hyyr	344	60	an	an	DT
cord-006860-a3b8hyyr	344	61	in	in	IN
cord-006860-a3b8hyyr	344	62	vifro	vifro	NNP
cord-006860-a3b8hyyr	344	63	and	and	CC
cord-006860-a3b8hyyr	344	64	in	in	IN
cord-006860-a3b8hyyr	344	65	vivo	vivo	NNP
cord-006860-a3b8hyyr	344	66	.	.	.
cord-006860-a3b8hyyr	345	1	Anticollagen	Anticollagen	NNP
cord-006860-a3b8hyyr	345	2	antibodies	antibody	NNS
cord-006860-a3b8hyyr	345	3	and	and	CC
cord-006860-a3b8hyyr	345	4	bispecific	bispecific	NN
cord-006860-a3b8hyyr	345	5	conjugate	conjugate	NN
cord-006860-a3b8hyyr	345	6	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	345	7	human	human	JJ
cord-006860-a3b8hyyr	345	8	platelet	platelet	NN
cord-006860-a3b8hyyr	345	9	adhesion	adhesion	NN
cord-006860-a3b8hyyr	345	10	,	,	,
cord-006860-a3b8hyyr	345	11	aggregation	aggregation	NN
cord-006860-a3b8hyyr	345	12	and	and	CC
cord-006860-a3b8hyyr	345	13	formation	formation	NN
cord-006860-a3b8hyyr	345	14	of	of	IN
cord-006860-a3b8hyyr	345	15	thrombi	thrombi	NN
cord-006860-a3b8hyyr	345	16	-	-	HYPH
cord-006860-a3b8hyyr	345	17	like	like	JJ
cord-006860-a3b8hyyr	345	18	~ructures	~ructures	NFP
cord-006860-a3b8hyyr	345	19	induced	induce	VBN
cord-006860-a3b8hyyr	345	20	by	by	IN
cord-006860-a3b8hyyr	345	21	rat	rat	NN
cord-006860-a3b8hyyr	345	22	collagen	collagen	NN
cord-006860-a3b8hyyr	345	23	immobilized	immobilize	VBN
cord-006860-a3b8hyyr	345	24	with	with	IN
cord-006860-a3b8hyyr	345	25	the	the	DT
cord-006860-a3b8hyyr	345	26	polystiroi	polystiroi	JJ
cord-006860-a3b8hyyr	345	27	surface	surface	NN
cord-006860-a3b8hyyr	345	28	in	in	IN
cord-006860-a3b8hyyr	345	29	a	a	DT
cord-006860-a3b8hyyr	345	30	condition	condition	NN
cord-006860-a3b8hyyr	345	31	mimics	mimic	VBZ
cord-006860-a3b8hyyr	345	32	the	the	DT
cord-006860-a3b8hyyr	345	33	high	high	JJ
cord-006860-a3b8hyyr	345	34	shear	shear	NN
cord-006860-a3b8hyyr	345	35	rate	rate	NN
cord-006860-a3b8hyyr	345	36	in	in	IN
cord-006860-a3b8hyyr	345	37	the	the	DT
cord-006860-a3b8hyyr	345	38	large	large	JJ
cord-006860-a3b8hyyr	345	39	elastic	elastic	JJ
cord-006860-a3b8hyyr	345	40	-	-	HYPH
cord-006860-a3b8hyyr	345	41	type	type	NN
cord-006860-a3b8hyyr	345	42	arteries	artery	NNS
cord-006860-a3b8hyyr	345	43	.	.	.
cord-006860-a3b8hyyr	346	1	The	the	DT
cord-006860-a3b8hyyr	346	2	short	short	JJ
cord-006860-a3b8hyyr	346	3	-	-	HYPH
cord-006860-a3b8hyyr	346	4	term	term	NN
cord-006860-a3b8hyyr	346	5	treatment	treatment	NN
cord-006860-a3b8hyyr	346	6	of	of	IN
cord-006860-a3b8hyyr	346	7	the	the	DT
cord-006860-a3b8hyyr	346	8	collagen	collagen	NN
cord-006860-a3b8hyyr	346	9	-	-	HYPH
cord-006860-a3b8hyyr	346	10	soaked	soak	VBN
cord-006860-a3b8hyyr	346	11	silk	silk	NN
cord-006860-a3b8hyyr	346	12	thread	thread	NN
cord-006860-a3b8hyyr	346	13	by	by	IN
cord-006860-a3b8hyyr	346	14	the	the	DT
cord-006860-a3b8hyyr	346	15	collagen	collagen	NN
cord-006860-a3b8hyyr	346	16	antibodies	antibody	NNS
cord-006860-a3b8hyyr	346	17	suppressed	suppress	VBD
cord-006860-a3b8hyyr	346	18	the	the	DT
cord-006860-a3b8hyyr	346	19	platelet	platelet	NN
cord-006860-a3b8hyyr	346	20	-	-	HYPH
cord-006860-a3b8hyyr	346	21	dependent	dependent	JJ
cord-006860-a3b8hyyr	346	22	thrombus	thrombus	NN
cord-006860-a3b8hyyr	346	23	formation	formation	NN
cord-006860-a3b8hyyr	346	24	in	in	IN
cord-006860-a3b8hyyr	346	25	the	the	DT
cord-006860-a3b8hyyr	346	26	arterio	arterio	NN
cord-006860-a3b8hyyr	346	27	-	-	HYPH
cord-006860-a3b8hyyr	346	28	venous	venous	JJ
cord-006860-a3b8hyyr	346	29	shunt	shunt	NN
cord-006860-a3b8hyyr	346	30	in	in	IN
cord-006860-a3b8hyyr	346	31	rats	rat	NNS
cord-006860-a3b8hyyr	346	32	by	by	IN
cord-006860-a3b8hyyr	346	33	56_+4	56_+4	CD
cord-006860-a3b8hyyr	346	34	%	%	NN
cord-006860-a3b8hyyr	346	35	(	(	-LRB-
cord-006860-a3b8hyyr	346	36	P<0.001	P<0.001	NNP
cord-006860-a3b8hyyr	346	37	)	)	-RRB-
cord-006860-a3b8hyyr	346	38	as	as	RB
cord-006860-a3b8hyyr	346	39	well	well	RB
cord-006860-a3b8hyyr	346	40	as	as	IN
cord-006860-a3b8hyyr	346	41	by	by	IN
cord-006860-a3b8hyyr	346	42	the	the	DT
cord-006860-a3b8hyyr	346	43	bispecific	bispecific	NN
cord-006860-a3b8hyyr	346	44	conjugate	conjugate	NN
cord-006860-a3b8hyyr	346	45	(	(	-LRB-
cord-006860-a3b8hyyr	346	46	44_+4	44_+4	CD
cord-006860-a3b8hyyr	346	47	%	%	NN
cord-006860-a3b8hyyr	346	48	,	,	,
cord-006860-a3b8hyyr	346	49	P<0.001	P<0.001	NNP
cord-006860-a3b8hyyr	346	50	)	)	-RRB-
cord-006860-a3b8hyyr	346	51	.	.	.
cord-006860-a3b8hyyr	347	1	The	the	DT
cord-006860-a3b8hyyr	347	2	treatment	treatment	NN
cord-006860-a3b8hyyr	347	3	of	of	IN
cord-006860-a3b8hyyr	347	4	collagen	collagen	NN
cord-006860-a3b8hyyr	347	5	-	-	HYPH
cord-006860-a3b8hyyr	347	6	adsorbed	adsorb	VBN
cord-006860-a3b8hyyr	347	7	conjugate	conjugate	NN
cord-006860-a3b8hyyr	347	8	by	by	IN
cord-006860-a3b8hyyr	347	9	rtcu	rtcu	NNP
cord-006860-a3b8hyyr	347	10	-	-	HYPH
cord-006860-a3b8hyyr	347	11	PA	PA	NNP
cord-006860-a3b8hyyr	347	12	did	do	VBD
cord-006860-a3b8hyyr	347	13	not	not	RB
cord-006860-a3b8hyyr	347	14	increase	increase	VB
cord-006860-a3b8hyyr	347	15	the	the	DT
cord-006860-a3b8hyyr	347	16	autithrombotic	autithrombotic	JJ
cord-006860-a3b8hyyr	347	17	effect	effect	NN
cord-006860-a3b8hyyr	347	18	of	of	IN
cord-006860-a3b8hyyr	347	19	bifunctional	bifunctional	JJ
cord-006860-a3b8hyyr	347	20	antibodies	antibody	NNS
cord-006860-a3b8hyyr	347	21	.	.	.
cord-006860-a3b8hyyr	348	1	The	the	DT
cord-006860-a3b8hyyr	348	2	present	present	JJ
cord-006860-a3b8hyyr	348	3	date	date	NN
cord-006860-a3b8hyyr	348	4	suggest	suggest	VBP
cord-006860-a3b8hyyr	348	5	,	,	,
cord-006860-a3b8hyyr	348	6	that	that	IN
cord-006860-a3b8hyyr	348	7	the	the	DT
cord-006860-a3b8hyyr	348	8	local	local	JJ
cord-006860-a3b8hyyr	348	9	administration	administration	NN
cord-006860-a3b8hyyr	348	10	of	of	IN
cord-006860-a3b8hyyr	348	11	the	the	DT
cord-006860-a3b8hyyr	348	12	anticollagen	anticollagen	NNP
cord-006860-a3b8hyyr	348	13	antibodies	antibody	NNS
cord-006860-a3b8hyyr	348	14	at	at	IN
cord-006860-a3b8hyyr	348	15	the	the	DT
cord-006860-a3b8hyyr	348	16	site	site	NN
cord-006860-a3b8hyyr	348	17	of	of	IN
cord-006860-a3b8hyyr	348	18	atherosclerotic	atherosclerotic	JJ
cord-006860-a3b8hyyr	348	19	plague	plague	NN
cord-006860-a3b8hyyr	348	20	rapture	rapture	NN
cord-006860-a3b8hyyr	348	21	may	may	MD
cord-006860-a3b8hyyr	348	22	tm	tm	VB
cord-006860-a3b8hyyr	348	23	the	the	DT
cord-006860-a3b8hyyr	348	24	efficient	efficient	JJ
cord-006860-a3b8hyyr	348	25	tool	tool	NN
cord-006860-a3b8hyyr	348	26	for	for	IN
cord-006860-a3b8hyyr	348	27	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	348	28	of	of	IN
cord-006860-a3b8hyyr	348	29	platelet	platelet	NN
cord-006860-a3b8hyyr	348	30	-	-	HYPH
cord-006860-a3b8hyyr	348	31	dependent	dependent	JJ
cord-006860-a3b8hyyr	348	32	thrombus	thrombus	NN
cord-006860-a3b8hyyr	348	33	formation	formation	NN
cord-006860-a3b8hyyr	348	34	in	in	IN
cord-006860-a3b8hyyr	348	35	arteries	artery	NNS
cord-006860-a3b8hyyr	348	36	after	after	IN
cord-006860-a3b8hyyr	348	37	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	348	38	.	.	.
cord-006860-a3b8hyyr	349	1	Increased	increase	VBN
cord-006860-a3b8hyyr	349	2	levels	level	NNS
cord-006860-a3b8hyyr	349	3	of	of	IN
cord-006860-a3b8hyyr	349	4	certain	certain	JJ
cord-006860-a3b8hyyr	349	5	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	349	6	factors	factor	NNS
cord-006860-a3b8hyyr	349	7	have	have	VBP
cord-006860-a3b8hyyr	349	8	been	be	VBN
cord-006860-a3b8hyyr	349	9	shown	show	VBN
cord-006860-a3b8hyyr	349	10	to	to	TO
cord-006860-a3b8hyyr	349	11	be	be	VB
cord-006860-a3b8hyyr	349	12	related	relate	VBN
cord-006860-a3b8hyyr	349	13	to	to	IN
cord-006860-a3b8hyyr	349	14	an	an	DT
cord-006860-a3b8hyyr	349	15	increased	increase	VBN
cord-006860-a3b8hyyr	349	16	risk	risk	NN
cord-006860-a3b8hyyr	349	17	of	of	IN
cord-006860-a3b8hyyr	349	18	cardiovascular	cardiovascular	JJ
cord-006860-a3b8hyyr	349	19	events	event	NNS
cord-006860-a3b8hyyr	349	20	.	.	.
cord-006860-a3b8hyyr	350	1	Hypercoagulability	Hypercoagulability	NNP
cord-006860-a3b8hyyr	350	2	is	be	VBZ
cord-006860-a3b8hyyr	350	3	suggested	suggest	VBN
cord-006860-a3b8hyyr	350	4	to	to	TO
cord-006860-a3b8hyyr	350	5	predispose	predispose	VB
cord-006860-a3b8hyyr	350	6	to	to	IN
cord-006860-a3b8hyyr	350	7	arterial	arterial	JJ
cord-006860-a3b8hyyr	350	8	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	350	9	and	and	CC
cord-006860-a3b8hyyr	350	10	thereby	thereby	RB
cord-006860-a3b8hyyr	350	11	to	to	TO
cord-006860-a3b8hyyr	350	12	participate	participate	VB
cord-006860-a3b8hyyr	350	13	in	in	IN
cord-006860-a3b8hyyr	350	14	atherogcncsis	atherogcncsis	NN
cord-006860-a3b8hyyr	350	15	.	.	.
cord-006860-a3b8hyyr	351	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	351	2	therefore	therefore	RB
cord-006860-a3b8hyyr	351	3	assessed	assess	VBD
cord-006860-a3b8hyyr	351	4	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	351	5	,	,	,
cord-006860-a3b8hyyr	351	6	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	351	7	fragment	fragment	NN
cord-006860-a3b8hyyr	351	8	1	1	CD
cord-006860-a3b8hyyr	351	9	+	+	SYM
cord-006860-a3b8hyyr	351	10	2	2	CD
cord-006860-a3b8hyyr	351	11	(	(	-LRB-
cord-006860-a3b8hyyr	351	12	FI+2	FI+2	NNP
cord-006860-a3b8hyyr	351	13	)	)	-RRB-
cord-006860-a3b8hyyr	351	14	and	and	CC
cord-006860-a3b8hyyr	351	15	yon	yon	NNP
cord-006860-a3b8hyyr	351	16	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	351	17	factor	factor	NN
cord-006860-a3b8hyyr	351	18	(	(	-LRB-
cord-006860-a3b8hyyr	351	19	vWf	vWf	NNS
cord-006860-a3b8hyyr	351	20	)	)	-RRB-
cord-006860-a3b8hyyr	351	21	antigen	antigen	NN
cord-006860-a3b8hyyr	351	22	in	in	IN
cord-006860-a3b8hyyr	351	23	80	80	CD
cord-006860-a3b8hyyr	351	24	consecutive	consecutive	JJ
cord-006860-a3b8hyyr	351	25	patients	patient	NNS
cord-006860-a3b8hyyr	351	26	(	(	-LRB-
cord-006860-a3b8hyyr	351	27	aged	age	VBN
cord-006860-a3b8hyyr	351	28	59	59	CD
cord-006860-a3b8hyyr	351	29	+	+	SYM
cord-006860-a3b8hyyr	351	30	5	5	CD
cord-006860-a3b8hyyr	351	31	years	year	NNS
cord-006860-a3b8hyyr	351	32	)	)	-RRB-
cord-006860-a3b8hyyr	351	33	with	with	IN
cord-006860-a3b8hyyr	351	34	known	know	VBN
cord-006860-a3b8hyyr	351	35	coronary	coronary	JJ
cord-006860-a3b8hyyr	351	36	artery	artery	NN
cord-006860-a3b8hyyr	351	37	disease	disease	NN
cord-006860-a3b8hyyr	351	38	(	(	-LRB-
cord-006860-a3b8hyyr	351	39	CAD	CAD	NNP
cord-006860-a3b8hyyr	351	40	)	)	-RRB-
cord-006860-a3b8hyyr	351	41	who	who	WP
cord-006860-a3b8hyyr	351	42	all	all	DT
cord-006860-a3b8hyyr	351	43	underwent	undergo	VBD
cord-006860-a3b8hyyr	351	44	coronary	coronary	JJ
cord-006860-a3b8hyyr	351	45	angiography	angiography	NN
cord-006860-a3b8hyyr	351	46	.	.	.
cord-006860-a3b8hyyr	352	1	The	the	DT
cord-006860-a3b8hyyr	352	2	extent	extent	NN
cord-006860-a3b8hyyr	352	3	of	of	IN
cord-006860-a3b8hyyr	352	4	coronary	coronary	JJ
cord-006860-a3b8hyyr	352	5	artery	artery	NN
cord-006860-a3b8hyyr	352	6	disease	disease	NN
cord-006860-a3b8hyyr	352	7	was	be	VBD
cord-006860-a3b8hyyr	352	8	quantified	quantify	VBN
cord-006860-a3b8hyyr	352	9	according	accord	VBG
cord-006860-a3b8hyyr	352	10	to	to	IN
cord-006860-a3b8hyyr	352	11	modified	modify	VBN
cord-006860-a3b8hyyr	352	12	criteria	criterion	NNS
cord-006860-a3b8hyyr	352	13	of	of	IN
cord-006860-a3b8hyyr	352	14	the	the	DT
cord-006860-a3b8hyyr	352	15	American	American	NNP
cord-006860-a3b8hyyr	352	16	Heart	Heart	NNP
cord-006860-a3b8hyyr	352	17	association	association	NN
cord-006860-a3b8hyyr	352	18	(	(	-LRB-
cord-006860-a3b8hyyr	352	19	total	total	JJ
cord-006860-a3b8hyyr	352	20	,	,	,
cord-006860-a3b8hyyr	352	21	proximal	proximal	JJ
cord-006860-a3b8hyyr	352	22	and	and	CC
cord-006860-a3b8hyyr	352	23	distal	distal	JJ
cord-006860-a3b8hyyr	352	24	"	"	``
cord-006860-a3b8hyyr	352	25	score	score	NN
cord-006860-a3b8hyyr	352	26	"	"	''
cord-006860-a3b8hyyr	352	27	)	)	-RRB-
cord-006860-a3b8hyyr	352	28	.	.	.
cord-006860-a3b8hyyr	353	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	353	2	the	the	DT
cord-006860-a3b8hyyr	353	3	intima	intima	NN
cord-006860-a3b8hyyr	353	4	-	-	HYPH
cord-006860-a3b8hyyr	353	5	media	medium	NNS
cord-006860-a3b8hyyr	353	6	thickness	thickness	NN
cord-006860-a3b8hyyr	353	7	(	(	-LRB-
cord-006860-a3b8hyyr	353	8	IMT	IMT	NNP
cord-006860-a3b8hyyr	353	9	)	)	-RRB-
cord-006860-a3b8hyyr	353	10	was	be	VBD
cord-006860-a3b8hyyr	353	11	determined	determine	VBN
cord-006860-a3b8hyyr	353	12	in	in	IN
cord-006860-a3b8hyyr	353	13	the	the	DT
cord-006860-a3b8hyyr	353	14	carotid	carotid	JJ
cord-006860-a3b8hyyr	353	15	and	and	CC
cord-006860-a3b8hyyr	353	16	femoral	femoral	JJ
cord-006860-a3b8hyyr	353	17	arteries	artery	NNS
cord-006860-a3b8hyyr	353	18	by	by	IN
cord-006860-a3b8hyyr	353	19	standardized	standardized	JJ
cord-006860-a3b8hyyr	353	20	ultrasonographie	ultrasonographie	NNP
cord-006860-a3b8hyyr	353	21	measurement	measurement	NN
cord-006860-a3b8hyyr	353	22	,	,	,
cord-006860-a3b8hyyr	353	23	vWf	vWf	NNP
cord-006860-a3b8hyyr	353	24	antigen	antigen	NNP
cord-006860-a3b8hyyr	353	25	was	be	VBD
cord-006860-a3b8hyyr	353	26	found	find	VBN
cord-006860-a3b8hyyr	353	27	to	to	TO
cord-006860-a3b8hyyr	353	28	correlate	correlate	VB
cord-006860-a3b8hyyr	353	29	positively	positively	RB
cord-006860-a3b8hyyr	353	30	with	with	IN
cord-006860-a3b8hyyr	353	31	the	the	DT
cord-006860-a3b8hyyr	353	32	total	total	JJ
cord-006860-a3b8hyyr	353	33	and	and	CC
cord-006860-a3b8hyyr	353	34	proximal	proximal	JJ
cord-006860-a3b8hyyr	353	35	coronary	coronary	JJ
cord-006860-a3b8hyyr	353	36	score	score	NN
cord-006860-a3b8hyyr	353	37	(	(	-LRB-
cord-006860-a3b8hyyr	353	38	r=029	r=029	NNP
cord-006860-a3b8hyyr	353	39	,	,	,
cord-006860-a3b8hyyr	353	40	p<0.05	p<0.05	CD
cord-006860-a3b8hyyr	353	41	and	and	CC
cord-006860-a3b8hyyr	354	1	r	r	NN
cord-006860-a3b8hyyr	354	2	=	=	NN
cord-006860-a3b8hyyr	354	3	O.36	o.36	NN
cord-006860-a3b8hyyr	355	1	,	,	,
cord-006860-a3b8hyyr	355	2	p	p	NN
cord-006860-a3b8hyyr	355	3	<	<	XX
cord-006860-a3b8hyyr	355	4	0.01	0.01	CD
cord-006860-a3b8hyyr	355	5	)	)	-RRB-
cord-006860-a3b8hyyr	355	6	.	.	.
cord-006860-a3b8hyyr	356	1	While	while	IN
cord-006860-a3b8hyyr	356	2	FI+2	FI+2	NNP
cord-006860-a3b8hyyr	356	3	showed	show	VBD
cord-006860-a3b8hyyr	356	4	no	no	DT
cord-006860-a3b8hyyr	356	5	correlation	correlation	NN
cord-006860-a3b8hyyr	356	6	with	with	IN
cord-006860-a3b8hyyr	356	7	the	the	DT
cord-006860-a3b8hyyr	356	8	coronary	coronary	JJ
cord-006860-a3b8hyyr	356	9	scores	score	NNS
cord-006860-a3b8hyyr	356	10	,	,	,
cord-006860-a3b8hyyr	356	11	it	-PRON-	PRP
cord-006860-a3b8hyyr	356	12	was	be	VBD
cord-006860-a3b8hyyr	356	13	significantly	significantly	RB
cord-006860-a3b8hyyr	356	14	correlated	correlate	VBN
cord-006860-a3b8hyyr	356	15	with	with	IN
cord-006860-a3b8hyyr	356	16	the	the	DT
cord-006860-a3b8hyyr	356	17	IMT	IMT	NNP
cord-006860-a3b8hyyr	356	18	values	value	NNS
cord-006860-a3b8hyyr	356	19	in	in	IN
cord-006860-a3b8hyyr	356	20	the	the	DT
cord-006860-a3b8hyyr	356	21	carotid	carotid	JJ
cord-006860-a3b8hyyr	356	22	arteries	artery	NNS
cord-006860-a3b8hyyr	356	23	(	(	-LRB-
cord-006860-a3b8hyyr	356	24	r=0.27	r=0.27	NNP
cord-006860-a3b8hyyr	356	25	.	.	.
cord-006860-a3b8hyyr	357	1	p	p	NN
cord-006860-a3b8hyyr	357	2	<	<	XX
cord-006860-a3b8hyyr	357	3	0.05	0.05	CD
cord-006860-a3b8hyyr	357	4	)	)	-RRB-
cord-006860-a3b8hyyr	357	5	.	.	.
cord-006860-a3b8hyyr	358	1	After	after	IN
cord-006860-a3b8hyyr	358	2	differentiating	differentiate	VBG
cord-006860-a3b8hyyr	358	3	tertiles	tertile	NNS
cord-006860-a3b8hyyr	358	4	of	of	IN
cord-006860-a3b8hyyr	358	5	the	the	DT
cord-006860-a3b8hyyr	358	6	parameters	parameter	NNS
cord-006860-a3b8hyyr	358	7	patients	patient	NNS
cord-006860-a3b8hyyr	358	8	belonging	belong	VBG
cord-006860-a3b8hyyr	358	9	to	to	IN
cord-006860-a3b8hyyr	358	10	the	the	DT
cord-006860-a3b8hyyr	358	11	upper	upper	JJ
cord-006860-a3b8hyyr	358	12	tertile	tertile	NN
cord-006860-a3b8hyyr	358	13	of	of	IN
cord-006860-a3b8hyyr	358	14	FI+2	FI+2	NNP
cord-006860-a3b8hyyr	358	15	concentrations	concentration	NNS
cord-006860-a3b8hyyr	358	16	had	have	VBD
cord-006860-a3b8hyyr	358	17	significantly	significantly	RB
cord-006860-a3b8hyyr	358	18	higher	high	JJR
cord-006860-a3b8hyyr	358	19	IMT	IMT	NNP
cord-006860-a3b8hyyr	358	20	values	value	NNS
cord-006860-a3b8hyyr	358	21	of	of	IN
cord-006860-a3b8hyyr	358	22	the	the	DT
cord-006860-a3b8hyyr	358	23	carotid	carotid	JJ
cord-006860-a3b8hyyr	358	24	and	and	CC
cord-006860-a3b8hyyr	358	25	femoral	femoral	JJ
cord-006860-a3b8hyyr	358	26	arteries	artery	NNS
cord-006860-a3b8hyyr	358	27	(	(	-LRB-
cord-006860-a3b8hyyr	358	28	0.81_+0.11	0.81_+0.11	CD
cord-006860-a3b8hyyr	358	29	mm	mm	NN
cord-006860-a3b8hyyr	358	30	vs.	vs.	NN
cord-006860-a3b8hyyr	358	31	0.72+_0.13	0.72+_0.13	CD
cord-006860-a3b8hyyr	358	32	mm	mm	CD
cord-006860-a3b8hyyr	358	33	in	in	IN
cord-006860-a3b8hyyr	358	34	the	the	DT
cord-006860-a3b8hyyr	358	35	lower	low	JJR
cord-006860-a3b8hyyr	358	36	tertile	tertile	NN
cord-006860-a3b8hyyr	358	37	,	,	,
cord-006860-a3b8hyyr	358	38	p<0.05:1.38_+0.44	p<0.05:1.38_+0.44	VBZ
cord-006860-a3b8hyyr	358	39	mm	mm	NN
cord-006860-a3b8hyyr	358	40	vs.	vs.	FW
cord-006860-a3b8hyyr	358	41	I.	I.	NNP
cord-006860-a3b8hyyr	358	42	15-+0.25	15-+0.25	NN
cord-006860-a3b8hyyr	358	43	ram	ram	NN
cord-006860-a3b8hyyr	358	44	,	,	,
cord-006860-a3b8hyyr	358	45	p=0.05	p=0.05	JJ
cord-006860-a3b8hyyr	358	46	)	)	-RRB-
cord-006860-a3b8hyyr	358	47	whereas	whereas	IN
cord-006860-a3b8hyyr	358	48	in	in	IN
cord-006860-a3b8hyyr	358	49	patients	patient	NNS
cord-006860-a3b8hyyr	358	50	belonging	belong	VBG
cord-006860-a3b8hyyr	358	51	to	to	IN
cord-006860-a3b8hyyr	358	52	the	the	DT
cord-006860-a3b8hyyr	358	53	upper	upper	JJ
cord-006860-a3b8hyyr	358	54	tertile	tertile	NN
cord-006860-a3b8hyyr	358	55	of	of	IN
cord-006860-a3b8hyyr	358	56	vWf	vWf	NNP
cord-006860-a3b8hyyr	358	57	antigen	antigen	NNP
cord-006860-a3b8hyyr	358	58	concentrations	concentration	NNS
cord-006860-a3b8hyyr	358	59	the	the	DT
cord-006860-a3b8hyyr	358	60	proximal	proximal	JJ
cord-006860-a3b8hyyr	358	61	coronary	coronary	JJ
cord-006860-a3b8hyyr	358	62	artery	artery	NN
cord-006860-a3b8hyyr	358	63	score	score	NN
cord-006860-a3b8hyyr	358	64	was	be	VBD
cord-006860-a3b8hyyr	358	65	significantly	significantly	RB
cord-006860-a3b8hyyr	358	66	higher	high	JJR
cord-006860-a3b8hyyr	358	67	(	(	-LRB-
cord-006860-a3b8hyyr	358	68	!	!	.
cord-006860-a3b8hyyr	358	69	.71-+0.59	.71-+0.59	.
cord-006860-a3b8hyyr	359	1	vs.	vs.	NN
cord-006860-a3b8hyyr	359	2	1.31	1.31	CD
cord-006860-a3b8hyyr	359	3	+	+	CD
cord-006860-a3b8hyyr	359	4	0.92	0.92	CD
cord-006860-a3b8hyyr	359	5	in	in	IN
cord-006860-a3b8hyyr	359	6	the	the	DT
cord-006860-a3b8hyyr	359	7	lower	lower	RBR
cord-006860-a3b8hyyr	359	8	fertile	fertile	JJ
cord-006860-a3b8hyyr	359	9	,	,	,
cord-006860-a3b8hyyr	359	10	p<0.01	p<0.01	NNP
cord-006860-a3b8hyyr	359	11	)	)	-RRB-
cord-006860-a3b8hyyr	359	12	.	.	.
cord-006860-a3b8hyyr	360	1	Fro	fro	JJ
cord-006860-a3b8hyyr	360	2	correlation	correlation	NN
cord-006860-a3b8hyyr	360	3	of	of	IN
cord-006860-a3b8hyyr	360	4	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	360	5	concentrations	concentration	NNS
cord-006860-a3b8hyyr	360	6	and	and	CC
cord-006860-a3b8hyyr	360	7	extent	extent	NN
cord-006860-a3b8hyyr	360	8	of	of	IN
cord-006860-a3b8hyyr	360	9	CAD	CAD	NNP
cord-006860-a3b8hyyr	360	10	or	or	CC
cord-006860-a3b8hyyr	360	11	IMT	IMT	NNP
cord-006860-a3b8hyyr	360	12	values	value	NNS
cord-006860-a3b8hyyr	360	13	of	of	IN
cord-006860-a3b8hyyr	360	14	the	the	DT
cord-006860-a3b8hyyr	360	15	carotid	carotid	JJ
cord-006860-a3b8hyyr	360	16	and	and	CC
cord-006860-a3b8hyyr	360	17	femoral	femoral	JJ
cord-006860-a3b8hyyr	360	18	arteries	artery	NNS
cord-006860-a3b8hyyr	360	19	could	could	MD
cord-006860-a3b8hyyr	360	20	be	be	VB
cord-006860-a3b8hyyr	360	21	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	360	22	.	.	.
cord-006860-a3b8hyyr	361	1	In	in	IN
cord-006860-a3b8hyyr	361	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	361	3	procoagnlatory	procoagnlatory	NN
cord-006860-a3b8hyyr	361	4	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	361	5	as	as	IN
cord-006860-a3b8hyyr	361	6	indicated	indicate	VBN
cord-006860-a3b8hyyr	361	7	by	by	IN
cord-006860-a3b8hyyr	361	8	elevated	elevated	JJ
cord-006860-a3b8hyyr	361	9	concentrations	concentration	NNS
cord-006860-a3b8hyyr	361	10	of	of	IN
cord-006860-a3b8hyyr	361	11	yon	yon	NNP
cord-006860-a3b8hyyr	361	12	Willehrand	Willehrand	NNP
cord-006860-a3b8hyyr	361	13	factor	factor	NN
cord-006860-a3b8hyyr	361	14	antigen	antigen	NN
cord-006860-a3b8hyyr	361	15	and	and	CC
cord-006860-a3b8hyyr	361	16	FI+2	FI+2	NNP
cord-006860-a3b8hyyr	361	17	may	may	MD
cord-006860-a3b8hyyr	361	18	be	be	VB
cord-006860-a3b8hyyr	361	19	contributing	contribute	VBG
cord-006860-a3b8hyyr	361	20	factors	factor	NNS
cord-006860-a3b8hyyr	361	21	in	in	IN
cord-006860-a3b8hyyr	361	22	atherogenesis	atherogenesis	NN
cord-006860-a3b8hyyr	361	23	.	.	.
cord-006860-a3b8hyyr	362	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	362	2	have	have	VBP
cord-006860-a3b8hyyr	362	3	previously	previously	RB
cord-006860-a3b8hyyr	362	4	shown	show	VBN
cord-006860-a3b8hyyr	362	5	that	that	IN
cord-006860-a3b8hyyr	362	6	PGEI	PGEI	NNP
cord-006860-a3b8hyyr	362	7	is	be	VBZ
cord-006860-a3b8hyyr	362	8	a	a	DT
cord-006860-a3b8hyyr	362	9	potent	potent	JJ
cord-006860-a3b8hyyr	362	10	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	362	11	of	of	IN
cord-006860-a3b8hyyr	362	12	PDGF	PDGF	NNP
cord-006860-a3b8hyyr	362	13	-	-	HYPH
cord-006860-a3b8hyyr	362	14	ioducod	ioducod	JJ
cord-006860-a3b8hyyr	362	15	proliferation	proliferation	NN
cord-006860-a3b8hyyr	362	16	of	of	IN
cord-006860-a3b8hyyr	362	17	vascniar	vascniar	NN
cord-006860-a3b8hyyr	362	18	smooth	smooth	JJ
cord-006860-a3b8hyyr	362	19	muscle	muscle	NN
cord-006860-a3b8hyyr	362	20	cells	cell	NNS
cord-006860-a3b8hyyr	362	21	(	(	-LRB-
cord-006860-a3b8hyyr	362	22	VSCM	VSCM	NNP
cord-006860-a3b8hyyr	362	23	)	)	-RRB-
cord-006860-a3b8hyyr	362	24	and	and	CC
cord-006860-a3b8hyyr	362	25	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	362	26	DNA	dna	NN
cord-006860-a3b8hyyr	362	27	replication	replication	NN
cord-006860-a3b8hyyr	362	28	by	by	IN
cord-006860-a3b8hyyr	362	29	a	a	DT
cord-006860-a3b8hyyr	362	30	cAMP	camp	NN
cord-006860-a3b8hyyr	362	31	-	-	HYPH
cord-006860-a3b8hyyr	362	32	related	relate	VBN
cord-006860-a3b8hyyr	362	33	mechanism	mechanism	NN
cord-006860-a3b8hyyr	362	34	(	(	-LRB-
cord-006860-a3b8hyyr	362	35	Grol	Grol	NNP
cord-006860-a3b8hyyr	362	36	~	~	NFP
cord-006860-a3b8hyyr	362	37	er	er	UH
cord-006860-a3b8hyyr	362	38	et	et	FW
cord-006860-a3b8hyyr	362	39	al	al	NNP
cord-006860-a3b8hyyr	362	40	,	,	,
cord-006860-a3b8hyyr	362	41	1994	1994	CD
cord-006860-a3b8hyyr	362	42	)	)	-RRB-
cord-006860-a3b8hyyr	362	43	.	.	.
cord-006860-a3b8hyyr	363	1	The	the	DT
cord-006860-a3b8hyyr	363	2	present	present	JJ
cord-006860-a3b8hyyr	363	3	study	study	NN
cord-006860-a3b8hyyr	363	4	investigates	investigate	NNS
cord-006860-a3b8hyyr	363	5	of	of	IN
cord-006860-a3b8hyyr	363	6	whether	whether	IN
cord-006860-a3b8hyyr	363	7	or	or	CC
cord-006860-a3b8hyyr	363	8	not	not	RB
cord-006860-a3b8hyyr	363	9	this	this	DT
cord-006860-a3b8hyyr	364	1	aatimitogeni¢	aatimitogeni¢	DT
cord-006860-a3b8hyyr	364	2	activity	activity	NN
cord-006860-a3b8hyyr	364	3	of	of	IN
cord-006860-a3b8hyyr	364	4	PGEt	PGEt	NNS
cord-006860-a3b8hyyr	364	5	can	can	MD
cord-006860-a3b8hyyr	364	6	be	be	VB
cord-006860-a3b8hyyr	364	7	amplified	amplify	VBN
cord-006860-a3b8hyyr	364	8	by	by	IN
cord-006860-a3b8hyyr	364	9	trapidil	trapidil	NN
cord-006860-a3b8hyyr	364	10	,	,	,
cord-006860-a3b8hyyr	364	11	a	a	DT
cord-006860-a3b8hyyr	364	12	compound	compound	NN
cord-006860-a3b8hyyr	364	13	that	that	WDT
cord-006860-a3b8hyyr	364	14	has	have	VBZ
cord-006860-a3b8hyyr	364	15	been	be	VBN
cord-006860-a3b8hyyr	364	16	shown	show	VBN
cord-006860-a3b8hyyr	364	17	recently	recently	RB
cord-006860-a3b8hyyr	364	18	to	to	TO
cord-006860-a3b8hyyr	364	19	inhibit	inhibit	VB
cord-006860-a3b8hyyr	364	20	the	the	DT
cord-006860-a3b8hyyr	364	21	incidence	incidence	NN
cord-006860-a3b8hyyr	364	22	of	of	IN
cord-006860-a3b8hyyr	364	23	restenosis	restenosis	NN
cord-006860-a3b8hyyr	364	24	of	of	IN
cord-006860-a3b8hyyr	364	25	hmnan	hmnan	NNP
cord-006860-a3b8hyyr	364	26	coronary	coronary	NNP
cord-006860-a3b8hyyr	364	27	arteries	artery	NNS
cord-006860-a3b8hyyr	364	28	subsequenmt	subsequenmt	NNP
cord-006860-a3b8hyyr	364	29	to	to	IN
cord-006860-a3b8hyyr	364	30	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	365	1	(	(	-LRB-
cord-006860-a3b8hyyr	365	2	Maresta	Maresta	NNP
cord-006860-a3b8hyyr	365	3	et	et	NNP
cord-006860-a3b8hyyr	365	4	al	al	NNP
cord-006860-a3b8hyyr	365	5	.	.	.
cord-006860-a3b8hyyr	365	6	1994	1994	CD
cord-006860-a3b8hyyr	365	7	)	)	-RRB-
cord-006860-a3b8hyyr	365	8	,	,	,
cord-006860-a3b8hyyr	365	9	VSMC	VSMC	NNP
cord-006860-a3b8hyyr	365	10	were	be	VBD
cord-006860-a3b8hyyr	365	11	prepared	prepare	VBN
cord-006860-a3b8hyyr	365	12	from	from	IN
cord-006860-a3b8hyyr	365	13	coronary	coronary	JJ
cord-006860-a3b8hyyr	365	14	arteries	artery	NNS
cord-006860-a3b8hyyr	365	15	of	of	IN
cord-006860-a3b8hyyr	365	16	adult	adult	NN
cord-006860-a3b8hyyr	365	17	bovine	bovine	JJ
cord-006860-a3b8hyyr	365	18	hearts	heart	NNS
cord-006860-a3b8hyyr	365	19	,	,	,
cord-006860-a3b8hyyr	365	20	passagod	passagod	NNP
cord-006860-a3b8hyyr	365	21	and	and	CC
cord-006860-a3b8hyyr	365	22	kept	keep	VBD
cord-006860-a3b8hyyr	365	23	under	under	IN
cord-006860-a3b8hyyr	365	24	standard	standard	JJ
cord-006860-a3b8hyyr	365	25	tissue	tissue	NN
cord-006860-a3b8hyyr	365	26	culture	culture	NN
cord-006860-a3b8hyyr	365	27	conditions	condition	NNS
cord-006860-a3b8hyyr	365	28	.	.	.
cord-006860-a3b8hyyr	366	1	Cells	cell	NNS
cord-006860-a3b8hyyr	366	2	of	of	IN
cord-006860-a3b8hyyr	366	3	passage	passage	NN
cord-006860-a3b8hyyr	366	4	4	4	CD
cord-006860-a3b8hyyr	366	5	-	-	SYM
cord-006860-a3b8hyyr	366	6	9	9	CD
cord-006860-a3b8hyyr	366	7	wore	wear	VBD
cord-006860-a3b8hyyr	366	8	incubated	incubate	VBN
cord-006860-a3b8hyyr	366	9	in	in	IN
cord-006860-a3b8hyyr	366	10	serumfree	serumfree	JJ
cord-006860-a3b8hyyr	366	11	medium	medium	NN
cord-006860-a3b8hyyr	366	12	for	for	IN
cord-006860-a3b8hyyr	366	13	24h	24h	NNS
cord-006860-a3b8hyyr	366	14	in	in	IN
cord-006860-a3b8hyyr	366	15	the	the	DT
cord-006860-a3b8hyyr	366	16	presence	presence	NN
cord-006860-a3b8hyyr	366	17	of	of	IN
cord-006860-a3b8hyyr	366	18	indomethacin	indomethacin	NN
cord-006860-a3b8hyyr	366	19	(	(	-LRB-
cord-006860-a3b8hyyr	366	20	3	3	CD
cord-006860-a3b8hyyr	366	21	p	p	NN
cord-006860-a3b8hyyr	366	22	.	.	.
cord-006860-a3b8hyyr	366	23	M	M	NNP
cord-006860-a3b8hyyr	366	24	)	)	-RRB-
cord-006860-a3b8hyyr	366	25	.	.	.
cord-006860-a3b8hyyr	367	1	Addition	addition	NN
cord-006860-a3b8hyyr	367	2	of	of	IN
cord-006860-a3b8hyyr	367	3	PDGF	PDGF	NNP
cord-006860-a3b8hyyr	367	4	-	-	HYPH
cord-006860-a3b8hyyr	367	5	BB	BB	NNP
cord-006860-a3b8hyyr	367	6	(	(	-LRB-
cord-006860-a3b8hyyr	367	7	10	10	CD
cord-006860-a3b8hyyr	367	8	ng	ng	NN
cord-006860-a3b8hyyr	367	9	/	/	SYM
cord-006860-a3b8hyyr	367	10	ml	ml	NN
cord-006860-a3b8hyyr	367	11	)	)	-RRB-
cord-006860-a3b8hyyr	367	12	under	under	IN
cord-006860-a3b8hyyr	367	13	these	these	DT
cord-006860-a3b8hyyr	367	14	conditions	condition	NNS
cord-006860-a3b8hyyr	367	15	stimulated	stimulate	VBD
cord-006860-a3b8hyyr	367	16	DNA	dna	NN
cord-006860-a3b8hyyr	367	17	-	-	HYPH
cord-006860-a3b8hyyr	367	18	replication	replication	NN
cord-006860-a3b8hyyr	367	19	as	as	IN
cord-006860-a3b8hyyr	367	20	assessed	assess	VBN
cord-006860-a3b8hyyr	367	21	from	from	IN
cord-006860-a3b8hyyr	367	22	'	'	''
cord-006860-a3b8hyyr	367	23	Hthymidin	Hthymidin	NNP
cord-006860-a3b8hyyr	367	24	lncm'poration	lncm'poration	NN
cord-006860-a3b8hyyr	367	25	,	,	,
cord-006860-a3b8hyyr	367	26	by	by	IN
cord-006860-a3b8hyyr	367	27	3.-4laid	3.-4laid	CD
cord-006860-a3b8hyyr	367	28	above	above	IN
cord-006860-a3b8hyyr	367	29	control	control	NN
cord-006860-a3b8hyyr	367	30	level	level	NN
cord-006860-a3b8hyyr	367	31	.	.	.
cord-006860-a3b8hyyr	368	1	Trapidil	Trapidil	NNP
cord-006860-a3b8hyyr	368	2	at	at	IN
cord-006860-a3b8hyyr	368	3	10	10	CD
cord-006860-a3b8hyyr	368	4	idvl	idvl	NNS
cord-006860-a3b8hyyr	368	5	caused	cause	VBD
cord-006860-a3b8hyyr	368	6	a	a	DT
cord-006860-a3b8hyyr	368	7	minor	minor	JJ
cord-006860-a3b8hyyr	368	8	reduction	reduction	NN
cord-006860-a3b8hyyr	368	9	of	of	IN
cord-006860-a3b8hyyr	368	10	PDGF	PDGF	NNP
cord-006860-a3b8hyyr	368	11	-	-	HYPH
cord-006860-a3b8hyyr	368	12	induced	induce	VBN
cord-006860-a3b8hyyr	368	13	mitogenesis	mitogenesis	NN
cord-006860-a3b8hyyr	368	14	whereas	whereas	IN
cord-006860-a3b8hyyr	368	15	10	10	CD
cord-006860-a3b8hyyr	368	16	t	t	NN
cord-006860-a3b8hyyr	368	17	)	)	-RRB-
cord-006860-a3b8hyyr	368	18	of	of	IN
cord-006860-a3b8hyyr	368	19	the	the	DT
cord-006860-a3b8hyyr	368	20	compound	compound	NN
cord-006860-a3b8hyyr	368	21	resulted	result	VBD
cord-006860-a3b8hyyr	368	22	in	in	IN
cord-006860-a3b8hyyr	368	23	a	a	DT
cord-006860-a3b8hyyr	368	24	marked	marked	JJ
cord-006860-a3b8hyyr	368	25	reduction	reduction	NN
cord-006860-a3b8hyyr	368	26	of	of	IN
cord-006860-a3b8hyyr	368	27	DNA	dna	NN
cord-006860-a3b8hyyr	368	28	replication	replication	NN
cord-006860-a3b8hyyr	368	29	by	by	IN
cord-006860-a3b8hyyr	368	30	69	69	CD
cord-006860-a3b8hyyr	368	31	%	%	NN
cord-006860-a3b8hyyr	368	32	(	(	-LRB-
cord-006860-a3b8hyyr	368	33	P	p	NN
cord-006860-a3b8hyyr	368	34	<	<	XX
cord-006860-a3b8hyyr	368	35	0.05	0.05	CD
cord-006860-a3b8hyyr	368	36	,	,	,
cord-006860-a3b8hyyr	368	37	n	n	NN
cord-006860-a3b8hyyr	368	38	=	=	SYM
cord-006860-a3b8hyyr	368	39	4	4	CD
cord-006860-a3b8hyyr	368	40	)	)	-RRB-
cord-006860-a3b8hyyr	368	41	.	.	.
cord-006860-a3b8hyyr	369	1	PGEI	PGEI	NNP
cord-006860-a3b8hyyr	369	2	at	at	IN
cord-006860-a3b8hyyr	369	3	0.3	0.3	CD
cord-006860-a3b8hyyr	369	4	nM	nm	CD
cord-006860-a3b8hyyr	369	5	diminished	diminish	VBD
cord-006860-a3b8hyyr	369	6	the	the	DT
cord-006860-a3b8hyyr	369	7	incorporation	incorporation	NN
cord-006860-a3b8hyyr	369	8	rate	rate	NN
cord-006860-a3b8hyyr	369	9	by	by	IN
cord-006860-a3b8hyyr	369	10	t	t	NNP
cord-006860-a3b8hyyr	369	11	1	1	CD
cord-006860-a3b8hyyr	369	12	%	%	NN
cord-006860-a3b8hyyr	369	13	while	while	IN
cord-006860-a3b8hyyr	369	14	the	the	DT
cord-006860-a3b8hyyr	369	15	simultaneous	simultaneous	JJ
cord-006860-a3b8hyyr	369	16	administration	administration	NN
cord-006860-a3b8hyyr	369	17	of	of	IN
cord-006860-a3b8hyyr	369	18	both	both	CC
cord-006860-a3b8hyyr	369	19	PGED	PGED	NNP
cord-006860-a3b8hyyr	369	20	and	and	CC
cord-006860-a3b8hyyr	369	21	trapidil	trapidil	NN
cord-006860-a3b8hyyr	369	22	(	(	-LRB-
cord-006860-a3b8hyyr	369	23	100	100	CD
cord-006860-a3b8hyyr	369	24	idyll	idyll	NN
cord-006860-a3b8hyyr	369	25	caused	cause	VBD
cord-006860-a3b8hyyr	369	26	a	a	DT
cord-006860-a3b8hyyr	369	27	significantly	significantly	RB
cord-006860-a3b8hyyr	369	28	stronger	strong	JJR
cord-006860-a3b8hyyr	369	29	response	response	NN
cord-006860-a3b8hyyr	369	30	as	as	IN
cord-006860-a3b8hyyr	369	31	seen	see	VBN
cord-006860-a3b8hyyr	369	32	from	from	IN
cord-006860-a3b8hyyr	369	33	n	n	CD
cord-006860-a3b8hyyr	369	34	reduction	reduction	NN
cord-006860-a3b8hyyr	369	35	of	of	IN
cord-006860-a3b8hyyr	369	36	~H	~h	JJ
cord-006860-a3b8hyyr	369	37	-	-	HYPH
cord-006860-a3b8hyyr	369	38	thymidine	thymidine	NN
cord-006860-a3b8hyyr	369	39	incorporation	incorporation	NN
cord-006860-a3b8hyyr	369	40	rate	rate	NN
cord-006860-a3b8hyyr	369	41	by	by	IN
cord-006860-a3b8hyyr	369	42	82	82	CD
cord-006860-a3b8hyyr	369	43	%	%	NN
cord-006860-a3b8hyyr	369	44	(	(	-LRB-
cord-006860-a3b8hyyr	369	45	P	p	NN
cord-006860-a3b8hyyr	369	46	<	<	XX
cord-006860-a3b8hyyr	369	47	0.05	0.05	CD
cord-006860-a3b8hyyr	369	48	,	,	,
cord-006860-a3b8hyyr	369	49	n	n	NN
cord-006860-a3b8hyyr	369	50	=	=	SYM
cord-006860-a3b8hyyr	369	51	4	4	CD
cord-006860-a3b8hyyr	369	52	)	)	-RRB-
cord-006860-a3b8hyyr	369	53	.	.	.
cord-006860-a3b8hyyr	370	1	As	as	IN
cord-006860-a3b8hyyr	370	2	a	a	DT
cord-006860-a3b8hyyr	370	3	possible	possible	JJ
cord-006860-a3b8hyyr	370	4	mechanism	mechanism	NN
cord-006860-a3b8hyyr	370	5	of	of	IN
cord-006860-a3b8hyyr	370	6	action	action	NN
cord-006860-a3b8hyyr	370	7	,	,	,
cord-006860-a3b8hyyr	370	8	trapidil	trapidil	NN
cord-006860-a3b8hyyr	370	9	might	may	MD
cord-006860-a3b8hyyr	370	10	have	have	VB
cord-006860-a3b8hyyr	370	11	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	370	12	phosphodiesterases	phosphodiesterase	NNS
cord-006860-a3b8hyyr	370	13	.	.	.
cord-006860-a3b8hyyr	371	1	To	to	TO
cord-006860-a3b8hyyr	371	2	establish	establish	VB
cord-006860-a3b8hyyr	371	3	this	this	DT
cord-006860-a3b8hyyr	371	4	,	,	,
cord-006860-a3b8hyyr	371	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	371	6	measured	measure	VBD
cord-006860-a3b8hyyr	371	7	the	the	DT
cord-006860-a3b8hyyr	371	8	cAMP	camp	NN
cord-006860-a3b8hyyr	371	9	-	-	HYPH
cord-006860-a3b8hyyr	371	10	depcudont	depcudont	NN
cord-006860-a3b8hyyr	371	11	proteinkiaasc	proteinkiaasc	NN
cord-006860-a3b8hyyr	371	12	(	(	-LRB-
cord-006860-a3b8hyyr	371	13	PK	PK	NNP
cord-006860-a3b8hyyr	371	14	)	)	-RRB-
cord-006860-a3b8hyyr	372	1	A	a	DT
cord-006860-a3b8hyyr	372	2	activity	activity	NN
cord-006860-a3b8hyyr	372	3	in	in	IN
cord-006860-a3b8hyyr	372	4	cell	cell	NN
cord-006860-a3b8hyyr	372	5	homogenates	homogenate	NNS
cord-006860-a3b8hyyr	372	6	.	.	.
cord-006860-a3b8hyyr	373	1	Trapfdil	Trapfdil	NNP
cord-006860-a3b8hyyr	373	2	increased	increase	VBD
cord-006860-a3b8hyyr	373	3	the	the	DT
cord-006860-a3b8hyyr	373	4	basal	basal	NN
cord-006860-a3b8hyyr	373	5	FKA	fka	NN
cord-006860-a3b8hyyr	373	6	-	-	HYPH
cord-006860-a3b8hyyr	373	7	activity	activity	NN
cord-006860-a3b8hyyr	373	8	from	from	IN
cord-006860-a3b8hyyr	373	9	19	19	CD
cord-006860-a3b8hyyr	373	10	%	%	NN
cord-006860-a3b8hyyr	373	11	tO	to	IN
cord-006860-a3b8hyyr	373	12	31	31	CD
cord-006860-a3b8hyyr	373	13	%	%	NN
cord-006860-a3b8hyyr	373	14	of	of	IN
cord-006860-a3b8hyyr	373	15	the	the	DT
cord-006860-a3b8hyyr	373	16	maximum	maximum	JJ
cord-006860-a3b8hyyr	373	17	reSpOnse	response	NN
cord-006860-a3b8hyyr	373	18	while	while	IN
cord-006860-a3b8hyyr	373	19	the	the	DT
cord-006860-a3b8hyyr	373	20	response	response	NN
cord-006860-a3b8hyyr	373	21	to	to	IN
cord-006860-a3b8hyyr	373	22	PGEt	PGEt	NNS
cord-006860-a3b8hyyr	373	23	(	(	-LRB-
cord-006860-a3b8hyyr	373	24	10	10	CD
cord-006860-a3b8hyyr	373	25	aM	am	NN
cord-006860-a3b8hyyr	373	26	)	)	-RRB-
cord-006860-a3b8hyyr	373	27	amounted	amount	VBD
cord-006860-a3b8hyyr	373	28	to	to	IN
cord-006860-a3b8hyyr	373	29	55	55	CD
cord-006860-a3b8hyyr	373	30	%	%	NN
cord-006860-a3b8hyyr	373	31	.	.	.
cord-006860-a3b8hyyr	374	1	Coincubation	coincubation	NN
cord-006860-a3b8hyyr	374	2	of	of	IN
cord-006860-a3b8hyyr	374	3	PGEI	PGEI	NNP
cord-006860-a3b8hyyr	374	4	with	with	IN
cord-006860-a3b8hyyr	374	5	trapidil	trapidil	NN
cord-006860-a3b8hyyr	374	6	caused	cause	VBD
cord-006860-a3b8hyyr	374	7	a	a	DT
cord-006860-a3b8hyyr	374	8	65	65	CD
cord-006860-a3b8hyyr	374	9	%	%	NN
cord-006860-a3b8hyyr	374	10	stimulation	stimulation	NN
cord-006860-a3b8hyyr	374	11	of	of	IN
cord-006860-a3b8hyyr	374	12	PKA	PKA	NNP
cord-006860-a3b8hyyr	374	13	activity	activity	NN
cord-006860-a3b8hyyr	374	14	,	,	,
cord-006860-a3b8hyyr	374	15	sugesting	sugeste	VBG
cord-006860-a3b8hyyr	374	16	a	a	DT
cord-006860-a3b8hyyr	374	17	small	small	JJ
cord-006860-a3b8hyyr	374	18	though	though	IN
cord-006860-a3b8hyyr	374	19	detectable	detectable	JJ
cord-006860-a3b8hyyr	374	20	inhibition	inhibition	NN
cord-006860-a3b8hyyr	374	21	of	of	IN
cord-006860-a3b8hyyr	374	22	VSCM	VSCM	NNP
cord-006860-a3b8hyyr	374	23	phosphodiesterases	phosphodiesterase	NNS
cord-006860-a3b8hyyr	374	24	by	by	IN
cord-006860-a3b8hyyr	374	25	trapidil	trapidil	NN
cord-006860-a3b8hyyr	374	26	at	at	IN
cord-006860-a3b8hyyr	374	27	anttmitogenic	anttmitogenic	NNP
cord-006860-a3b8hyyr	374	28	concentrations	concentration	NNS
cord-006860-a3b8hyyr	374	29	.	.	.
cord-006860-a3b8hyyr	375	1	Essentially	essentially	RB
cord-006860-a3b8hyyr	375	2	similar	similar	JJ
cord-006860-a3b8hyyr	375	3	results	result	NNS
cord-006860-a3b8hyyr	375	4	wore	wear	VBD
cord-006860-a3b8hyyr	375	5	obtained	obtain	VBN
cord-006860-a3b8hyyr	375	6	when	when	WRB
cord-006860-a3b8hyyr	375	7	thrombin	thrombin	NN
cord-006860-a3b8hyyr	375	8	was	be	VBD
cord-006860-a3b8hyyr	375	9	used	use	VBN
cord-006860-a3b8hyyr	375	10	as	as	IN
cord-006860-a3b8hyyr	375	11	the	the	DT
cord-006860-a3b8hyyr	375	12	mitogenic	mitogenic	NNP
cord-006860-a3b8hyyr	375	13	agent	agent	NN
cord-006860-a3b8hyyr	375	14	.	.	.
cord-006860-a3b8hyyr	376	1	The	the	DT
cord-006860-a3b8hyyr	376	2	data	datum	NNS
cord-006860-a3b8hyyr	376	3	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	376	4	a	a	DT
cord-006860-a3b8hyyr	376	5	significant	significant	JJ
cord-006860-a3b8hyyr	376	6	antimitogenic	antimitogenic	JJ
cord-006860-a3b8hyyr	376	7	effect	effect	NN
cord-006860-a3b8hyyr	376	8	of	of	IN
cord-006860-a3b8hyyr	376	9	trapidil	trapidil	NN
cord-006860-a3b8hyyr	376	10	at	at	IN
cord-006860-a3b8hyyr	376	11	p.molar	p.molar	NNP
cord-006860-a3b8hyyr	376	12	concentrations	concentration	NNS
cord-006860-a3b8hyyr	376	13	that	that	WDT
cord-006860-a3b8hyyr	376	14	are	be	VBP
cord-006860-a3b8hyyr	376	15	in	in	IN
cord-006860-a3b8hyyr	376	16	the	the	DT
cord-006860-a3b8hyyr	376	17	range	range	NN
cord-006860-a3b8hyyr	376	18	of	of	IN
cord-006860-a3b8hyyr	376	19	plasma	plasma	NN
cord-006860-a3b8hyyr	376	20	levels	level	NNS
cord-006860-a3b8hyyr	376	21	after	after	IN
cord-006860-a3b8hyyr	376	22	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	376	23	administration	administration	NN
cord-006860-a3b8hyyr	376	24	of	of	IN
cord-006860-a3b8hyyr	376	25	the	the	DT
cord-006860-a3b8hyyr	376	26	compound	compound	NN
cord-006860-a3b8hyyr	376	27	in	in	IN
cord-006860-a3b8hyyr	376	28	rive	rive	NNP
cord-006860-a3b8hyyr	376	29	.	.	.
cord-006860-a3b8hyyr	377	1	At	at	IN
cord-006860-a3b8hyyr	377	2	these	these	DT
cord-006860-a3b8hyyr	377	3	concentratrations	concentratration	NNS
cord-006860-a3b8hyyr	377	4	,	,	,
cord-006860-a3b8hyyr	377	5	PGEt	PGEt	NNS
cord-006860-a3b8hyyr	377	6	induced	induce	VBN
cord-006860-a3b8hyyr	377	7	inhibition	inhibition	NN
cord-006860-a3b8hyyr	377	8	of	of	IN
cord-006860-a3b8hyyr	377	9	mitogenesis	mitogenesis	NN
cord-006860-a3b8hyyr	377	10	is	be	VBZ
cord-006860-a3b8hyyr	377	11	markedly	markedly	RB
cord-006860-a3b8hyyr	377	12	enhanced	enhance	VBN
cord-006860-a3b8hyyr	377	13	by	by	IN
cord-006860-a3b8hyyr	377	14	trapidil	trapidil	NN
cord-006860-a3b8hyyr	377	15	.	.	.
cord-006860-a3b8hyyr	378	1	Inc.	Inc.	NNP
cord-006860-a3b8hyyr	378	2	I	I	NNP
cord-006860-a3b8hyyr	378	3	~	~	NNP
cord-006860-a3b8hyyr	378	4	enna	enna	NNP
cord-006860-a3b8hyyr	378	5	,	,	,
cord-006860-a3b8hyyr	378	6	and	and	CC
cord-006860-a3b8hyyr	378	7	~Cenlral	~cenlral	CD
cord-006860-a3b8hyyr	379	1	Itematnlogy	Itematnlogy	NNP
cord-006860-a3b8hyyr	379	2	Laboroto~.	laboroto~.	JJ
cord-006860-a3b8hyyr	379	3	,	,	,
cord-006860-a3b8hyyr	379	4	University	University	NNP
cord-006860-a3b8hyyr	379	5	Hospital	Hospital	NNP
cord-006860-a3b8hyyr	379	6	of	of	IN
cord-006860-a3b8hyyr	379	7	Bern	Bern	NNP
cord-006860-a3b8hyyr	379	8	Pibrinogen	Pibrinogen	NNP
cord-006860-a3b8hyyr	379	9	(	(	-LRB-
cord-006860-a3b8hyyr	379	10	Fg	Fg	NNP
cord-006860-a3b8hyyr	379	11	)	)	-RRB-
cord-006860-a3b8hyyr	379	12	,	,	,
cord-006860-a3b8hyyr	379	13	yon	yon	NNP
cord-006860-a3b8hyyr	379	14	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	379	15	factor	factor	NN
cord-006860-a3b8hyyr	379	16	antigen	antigen	NN
cord-006860-a3b8hyyr	379	17	(	(	-LRB-
cord-006860-a3b8hyyr	379	18	vWF	vwf	NN
cord-006860-a3b8hyyr	379	19	)	)	-RRB-
cord-006860-a3b8hyyr	379	20	and	and	CC
cord-006860-a3b8hyyr	379	21	tissue	tissue	NN
cord-006860-a3b8hyyr	379	22	-	-	HYPH
cord-006860-a3b8hyyr	379	23	type	type	NN
cord-006860-a3b8hyyr	379	24	plasminogeu	plasminogeu	NN
cord-006860-a3b8hyyr	379	25	activator	activator	NN
cord-006860-a3b8hyyr	379	26	antigen	antigen	NNP
cord-006860-a3b8hyyr	379	27	(	(	-LRB-
cord-006860-a3b8hyyr	379	28	l	l	NN
cord-006860-a3b8hyyr	379	29	-	-	HYPH
cord-006860-a3b8hyyr	379	30	PAl	PAl	NNS
cord-006860-a3b8hyyr	379	31	have	have	VBP
cord-006860-a3b8hyyr	379	32	recently	recently	RB
cord-006860-a3b8hyyr	379	33	been	be	VBN
cord-006860-a3b8hyyr	379	34	shown	show	VBN
cord-006860-a3b8hyyr	379	35	In	in	IN
cord-006860-a3b8hyyr	380	1	be	be	VB
cord-006860-a3b8hyyr	380	2	independent	independent	JJ
cord-006860-a3b8hyyr	380	3	risk	risk	NN
cord-006860-a3b8hyyr	380	4	factors	factor	NNS
cord-006860-a3b8hyyr	380	5	for	for	IN
cord-006860-a3b8hyyr	380	6	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	380	7	coronary	coronary	JJ
cord-006860-a3b8hyyr	380	8	events	event	NNS
cord-006860-a3b8hyyr	381	1	In	in	IN
cord-006860-a3b8hyyr	381	2	patients	patient	NNS
cord-006860-a3b8hyyr	381	3	with	with	IN
cord-006860-a3b8hyyr	381	4	angina	angina	NN
cord-006860-a3b8hyyr	381	5	pectoris	pectoris	NN
cord-006860-a3b8hyyr	381	6	(	(	-LRB-
cord-006860-a3b8hyyr	381	7	NEJM	NEJM	NNP
cord-006860-a3b8hyyr	381	8	1995	1995	CD
cord-006860-a3b8hyyr	381	9	;	;	:
cord-006860-a3b8hyyr	381	10	332:635	332:635	CD
cord-006860-a3b8hyyr	381	11	)	)	-RRB-
cord-006860-a3b8hyyr	382	1	Although	although	IN
cord-006860-a3b8hyyr	382	2	PAUl	PAUl	NNS
cord-006860-a3b8hyyr	382	3	antigen	antigen	NN
cord-006860-a3b8hyyr	382	4	has	have	VBZ
cord-006860-a3b8hyyr	382	5	also	also	RB
cord-006860-a3b8hyyr	382	6	been	be	VBN
cord-006860-a3b8hyyr	382	7	proposed	propose	VBN
cord-006860-a3b8hyyr	382	8	as	as	IN
cord-006860-a3b8hyyr	382	9	a	a	DT
cord-006860-a3b8hyyr	382	10	risk	risk	NN
cord-006860-a3b8hyyr	382	11	factor	factor	NN
cord-006860-a3b8hyyr	382	12	,	,	,
cord-006860-a3b8hyyr	382	13	conclusive	conclusive	JJ
cord-006860-a3b8hyyr	382	14	dam	dam	NN
cord-006860-a3b8hyyr	382	15	showing	show	VBG
cord-006860-a3b8hyyr	382	16	its	-PRON-	PRP$
cord-006860-a3b8hyyr	382	17	predictive	predictive	JJ
cord-006860-a3b8hyyr	382	18	value	value	NN
cord-006860-a3b8hyyr	382	19	is	be	VBZ
cord-006860-a3b8hyyr	382	20	still	still	RB
cord-006860-a3b8hyyr	382	21	lacking	lack	VBG
cord-006860-a3b8hyyr	382	22	.	.	.
cord-006860-a3b8hyyr	383	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	383	2	,	,	,
cord-006860-a3b8hyyr	383	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	383	4	have	have	VBP
cord-006860-a3b8hyyr	383	5	recently	recently	RB
cord-006860-a3b8hyyr	383	6	shown	show	VBN
cord-006860-a3b8hyyr	383	7	in	in	IN
cord-006860-a3b8hyyr	383	8	a	a	DT
cord-006860-a3b8hyyr	383	9	study	study	NN
cord-006860-a3b8hyyr	383	10	investigating	investigate	VBG
cord-006860-a3b8hyyr	383	11	200	200	CD
cord-006860-a3b8hyyr	383	12	survivors	survivor	NNS
cord-006860-a3b8hyyr	383	13	of	of	IN
cord-006860-a3b8hyyr	383	14	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	383	15	infarction	infarction	NN
cord-006860-a3b8hyyr	383	16	that	that	IN
cord-006860-a3b8hyyr	383	17	not	not	RB
cord-006860-a3b8hyyr	383	18	only	only	RB
cord-006860-a3b8hyyr	383	19	are	be	VBP
cord-006860-a3b8hyyr	383	20	Fg	Fg	NNP
cord-006860-a3b8hyyr	383	21	,	,	,
cord-006860-a3b8hyyr	383	22	t	t	NNP
cord-006860-a3b8hyyr	383	23	-	-	HYPH
cord-006860-a3b8hyyr	383	24	PA	PA	NNP
cord-006860-a3b8hyyr	383	25	and	and	CC
cord-006860-a3b8hyyr	383	26	PAI	PAI	NNP
cord-006860-a3b8hyyr	383	27	-	-	:
cord-006860-a3b8hyyr	383	28	I	-PRON-	PRP
cord-006860-a3b8hyyr	383	29	significantly	significantly	RB
cord-006860-a3b8hyyr	383	30	increased	increase	VBD
cord-006860-a3b8hyyr	383	31	in	in	IN
cord-006860-a3b8hyyr	383	32	these	these	DT
cord-006860-a3b8hyyr	383	33	patients	patient	NNS
cord-006860-a3b8hyyr	383	34	when	when	WRB
cord-006860-a3b8hyyr	383	35	compared	compare	VBN
cord-006860-a3b8hyyr	383	36	to	to	IN
cord-006860-a3b8hyyr	383	37	a	a	DT
cord-006860-a3b8hyyr	383	38	heahhy	heahhy	NNP
cord-006860-a3b8hyyr	383	39	conlro	conlro	NNP
cord-006860-a3b8hyyr	383	40	[	[	-LRB-
cord-006860-a3b8hyyr	383	41	group	group	NN
cord-006860-a3b8hyyr	383	42	,	,	,
cord-006860-a3b8hyyr	383	43	but	but	CC
cord-006860-a3b8hyyr	383	44	PCI	pci	NN
cord-006860-a3b8hyyr	383	45	activity	activity	NN
cord-006860-a3b8hyyr	383	46	is	be	VBZ
cord-006860-a3b8hyyr	383	47	also	also	RB
cord-006860-a3b8hyyr	383	48	elevated	elevate	VBN
cord-006860-a3b8hyyr	383	49	(	(	-LRB-
cord-006860-a3b8hyyr	383	50	7hrornb	7hrornb	NN
cord-006860-a3b8hyyr	383	51	.	.	.
cord-006860-a3b8hyyr	384	1	tfaemost	tfaemost	NNP
cord-006860-a3b8hyyr	384	2	.	.	.
cord-006860-a3b8hyyr	385	1	1995;73:1137	1995;73:1137	CD
cord-006860-a3b8hyyr	385	2	abst	abst	NNP
cord-006860-a3b8hyyr	385	3	.	.	.
cord-006860-a3b8hyyr	385	4	)	)	-RRB-
cord-006860-a3b8hyyr	385	5	,	,	.
cord-006860-a3b8hyyr	386	1	hi	hi	UH
cord-006860-a3b8hyyr	386	2	order	order	NN
cord-006860-a3b8hyyr	386	3	to	to	TO
cord-006860-a3b8hyyr	386	4	obtain	obtain	VB
cord-006860-a3b8hyyr	386	5	cut.off	cut.off	JJR
cord-006860-a3b8hyyr	386	6	points	point	NNS
cord-006860-a3b8hyyr	386	7	for	for	IN
cord-006860-a3b8hyyr	386	8	the	the	DT
cord-006860-a3b8hyyr	386	9	individual	individual	JJ
cord-006860-a3b8hyyr	386	10	parameters	parameter	NNS
cord-006860-a3b8hyyr	386	11	,	,	,
cord-006860-a3b8hyyr	386	12	frequenCy	frequency	CD
cord-006860-a3b8hyyr	386	13	histogram	histogram	NN
cord-006860-a3b8hyyr	386	14	plotl	plotl	NN
cord-006860-a3b8hyyr	386	15	;	;	:
cord-006860-a3b8hyyr	386	16	were	be	VBD
cord-006860-a3b8hyyr	386	17	transformed	transform	VBN
cord-006860-a3b8hyyr	386	18	into	into	IN
cord-006860-a3b8hyyr	386	19	straight	straight	JJ
cord-006860-a3b8hyyr	386	20	line	line	NN
cord-006860-a3b8hyyr	386	21	cumulative	cumulative	JJ
cord-006860-a3b8hyyr	386	22	frequency	frequency	NN
cord-006860-a3b8hyyr	386	23	(	(	-LRB-
cord-006860-a3b8hyyr	386	24	probit	probit	NNP
cord-006860-a3b8hyyr	386	25	)	)	-RRB-
cord-006860-a3b8hyyr	386	26	plots	plot	NNS
cord-006860-a3b8hyyr	387	1	(	(	-LRB-
cord-006860-a3b8hyyr	387	2	Thromb	Thromb	NNP
cord-006860-a3b8hyyr	387	3	I	I	NNP
cord-006860-a3b8hyyr	387	4	/	/	SYM
cord-006860-a3b8hyyr	387	5	aemost	aemost	NNP
cord-006860-a3b8hyyr	387	6	.	.	.
cord-006860-a3b8hyyr	387	7	1995;74:718	1995;74:718	CD
cord-006860-a3b8hyyr	387	8	)	)	-RRB-
cord-006860-a3b8hyyr	387	9	.	.	.
cord-006860-a3b8hyyr	388	1	The	the	DT
cord-006860-a3b8hyyr	388	2	cut	cut	VB
cord-006860-a3b8hyyr	388	3	-	-	HYPH
cord-006860-a3b8hyyr	388	4	off	off	RP
cord-006860-a3b8hyyr	388	5	valu~	valu~	NN
cord-006860-a3b8hyyr	388	6	for	for	IN
cord-006860-a3b8hyyr	388	7	the	the	DT
cord-006860-a3b8hyyr	388	8	four	four	CD
cord-006860-a3b8hyyr	388	9	parameters	parameter	NNS
cord-006860-a3b8hyyr	388	10	were	be	VBD
cord-006860-a3b8hyyr	388	11	determined	determine	VBN
cord-006860-a3b8hyyr	388	12	as	as	IN
cord-006860-a3b8hyyr	388	13	follows	follow	VBZ
cord-006860-a3b8hyyr	388	14	:	:	:
cord-006860-a3b8hyyr	389	1	Fg	Fg	NNP
cord-006860-a3b8hyyr	389	2	at	at	IN
cord-006860-a3b8hyyr	389	3	2.7	2.7	CD
cord-006860-a3b8hyyr	389	4	g	g	NN
cord-006860-a3b8hyyr	389	5	/	/	SYM
cord-006860-a3b8hyyr	389	6	L	L	NNP
cord-006860-a3b8hyyr	389	7	,	,	,
cord-006860-a3b8hyyr	389	8	t	t	NNP
cord-006860-a3b8hyyr	389	9	-	-	HYPH
cord-006860-a3b8hyyr	389	10	PA	PA	NNP
cord-006860-a3b8hyyr	389	11	at	at	IN
cord-006860-a3b8hyyr	389	12	8.7	8.7	CD
cord-006860-a3b8hyyr	389	13	ng	ng	NN
cord-006860-a3b8hyyr	389	14	/	/	SYM
cord-006860-a3b8hyyr	389	15	mL	ml	NN
cord-006860-a3b8hyyr	389	16	,	,	,
cord-006860-a3b8hyyr	389	17	PAl	PAl	NNS
cord-006860-a3b8hyyr	389	18	-	-	:
cord-006860-a3b8hyyr	389	19	I	-PRON-	PRP
cord-006860-a3b8hyyr	389	20	at	at	IN
cord-006860-a3b8hyyr	389	21	25	25	CD
cord-006860-a3b8hyyr	389	22	ng	ng	NN
cord-006860-a3b8hyyr	389	23	/	/	SYM
cord-006860-a3b8hyyr	389	24	mL	ml	NN
cord-006860-a3b8hyyr	389	25	and	and	CC
cord-006860-a3b8hyyr	389	26	PC	pc	NN
cord-006860-a3b8hyyr	389	27	[	[	-LRB-
cord-006860-a3b8hyyr	389	28	at	at	IN
cord-006860-a3b8hyyr	389	29	126	126	CD
cord-006860-a3b8hyyr	389	30	%	%	NN
cord-006860-a3b8hyyr	389	31	of	of	IN
cord-006860-a3b8hyyr	389	32	a	a	DT
cord-006860-a3b8hyyr	389	33	normal	normal	JJ
cord-006860-a3b8hyyr	389	34	pooled	pool	VBN
cord-006860-a3b8hyyr	389	35	plasma	plasma	NN
cord-006860-a3b8hyyr	389	36	.	.	.
cord-006860-a3b8hyyr	390	1	Utilising	utilise	VBG
cord-006860-a3b8hyyr	390	2	there	there	RB
cord-006860-a3b8hyyr	390	3	cut.off	cut.off	JJR
cord-006860-a3b8hyyr	390	4	points	point	NNS
cord-006860-a3b8hyyr	391	1	it	-PRON-	PRP
cord-006860-a3b8hyyr	391	2	was	be	VBD
cord-006860-a3b8hyyr	391	3	then	then	RB
cord-006860-a3b8hyyr	391	4	possible	possible	JJ
cord-006860-a3b8hyyr	391	5	to	to	TO
cord-006860-a3b8hyyr	391	6	determine	determine	VB
cord-006860-a3b8hyyr	391	7	the	the	DT
cord-006860-a3b8hyyr	391	8	accumulative	accumulative	JJ
cord-006860-a3b8hyyr	391	9	discriminatow	discriminatow	NN
cord-006860-a3b8hyyr	391	10	effectiveness	effectiveness	NN
cord-006860-a3b8hyyr	391	11	of	of	IN
cord-006860-a3b8hyyr	391	12	the	the	DT
cord-006860-a3b8hyyr	391	13	parameters	parameter	NNS
cord-006860-a3b8hyyr	391	14	.	.	.
cord-006860-a3b8hyyr	392	1	When	when	WRB
cord-006860-a3b8hyyr	392	2	Fg	Fg	NNP
cord-006860-a3b8hyyr	392	3	w;qs	w;qs	NNP
cord-006860-a3b8hyyr	392	4	employed	employ	VBN
cord-006860-a3b8hyyr	392	5	alone	alone	RB
cord-006860-a3b8hyyr	392	6	as	as	IN
cord-006860-a3b8hyyr	392	7	the	the	DT
cord-006860-a3b8hyyr	392	8	discriminatow	discriminatow	NN
cord-006860-a3b8hyyr	392	9	factor	factor	NN
cord-006860-a3b8hyyr	392	10	,	,	,
cord-006860-a3b8hyyr	392	11	it	-PRON-	PRP
cord-006860-a3b8hyyr	392	12	was	be	VBD
cord-006860-a3b8hyyr	392	13	observed	observe	VBN
cord-006860-a3b8hyyr	392	14	that	that	IN
cord-006860-a3b8hyyr	392	15	47	47	CD
cord-006860-a3b8hyyr	392	16	%	%	NN
cord-006860-a3b8hyyr	392	17	(	(	-LRB-
cord-006860-a3b8hyyr	392	18	941200	941200	CD
cord-006860-a3b8hyyr	392	19	)	)	-RRB-
cord-006860-a3b8hyyr	392	20	of	of	IN
cord-006860-a3b8hyyr	392	21	the	the	DT
cord-006860-a3b8hyyr	392	22	coronary	coronary	JJ
cord-006860-a3b8hyyr	392	23	heart	heart	NN
cord-006860-a3b8hyyr	392	24	dir	dir	NNP
cord-006860-a3b8hyyr	392	25	,	,	,
cord-006860-a3b8hyyr	392	26	ease	ease	NN
cord-006860-a3b8hyyr	392	27	(	(	-LRB-
cord-006860-a3b8hyyr	392	28	CHD	CHD	NNP
cord-006860-a3b8hyyr	392	29	)	)	-RRB-
cord-006860-a3b8hyyr	392	30	group	group	NNP
cord-006860-a3b8hyyr	392	31	eilher	eilher	NNP
cord-006860-a3b8hyyr	392	32	had	have	VBD
cord-006860-a3b8hyyr	392	33	the	the	DT
cord-006860-a3b8hyyr	392	34	cul	cul	NN
cord-006860-a3b8hyyr	392	35	..	..	NFP
cord-006860-a3b8hyyr	392	36	off	off	IN
cord-006860-a3b8hyyr	392	37	value	value	NN
cord-006860-a3b8hyyr	392	38	or	or	CC
cord-006860-a3b8hyyr	392	39	were	be	VBD
cord-006860-a3b8hyyr	392	40	below	below	IN
cord-006860-a3b8hyyr	392	41	it	-PRON-	PRP
cord-006860-a3b8hyyr	393	1	aud	aud	NNP
cord-006860-a3b8hyyr	393	2	29	29	CD
cord-006860-a3b8hyyr	393	3	%	%	NN
cord-006860-a3b8hyyr	393	4	(	(	-LRB-
cord-006860-a3b8hyyr	393	5	29199	29199	CD
cord-006860-a3b8hyyr	393	6	)	)	-RRB-
cord-006860-a3b8hyyr	393	7	of	of	IN
cord-006860-a3b8hyyr	393	8	the	the	DT
cord-006860-a3b8hyyr	393	9	normal	normal	JJ
cord-006860-a3b8hyyr	393	10	group	group	NN
cord-006860-a3b8hyyr	393	11	were	be	VBD
cord-006860-a3b8hyyr	393	12	above	above	IN
cord-006860-a3b8hyyr	393	13	the	the	DT
cord-006860-a3b8hyyr	393	14	cut	cut	VB
cord-006860-a3b8hyyr	393	15	-	-	HYPH
cord-006860-a3b8hyyr	393	16	off	off	RP
cord-006860-a3b8hyyr	393	17	value	value	NN
cord-006860-a3b8hyyr	393	18	,	,	,
cord-006860-a3b8hyyr	393	19	thus	thus	RB
cord-006860-a3b8hyyr	393	20	,	,	,
cord-006860-a3b8hyyr	393	21	resulting	result	VBG
cord-006860-a3b8hyyr	393	22	in	in	IN
cord-006860-a3b8hyyr	393	23	47	47	CD
cord-006860-a3b8hyyr	393	24	%	%	NN
cord-006860-a3b8hyyr	393	25	false	false	JJ
cord-006860-a3b8hyyr	393	26	ne$atives	ne$ative	NNS
cord-006860-a3b8hyyr	393	27	and	and	CC
cord-006860-a3b8hyyr	393	28	29	29	CD
cord-006860-a3b8hyyr	393	29	%	%	NN
cord-006860-a3b8hyyr	393	30	false	false	JJ
cord-006860-a3b8hyyr	393	31	positives	positive	NNS
cord-006860-a3b8hyyr	393	32	.	.	.
cord-006860-a3b8hyyr	394	1	When	when	WRB
cord-006860-a3b8hyyr	394	2	a	a	DT
cord-006860-a3b8hyyr	394	3	second	second	JJ
cord-006860-a3b8hyyr	394	4	additional	additional	JJ
cord-006860-a3b8hyyr	394	5	risk	risk	NN
cord-006860-a3b8hyyr	394	6	factor	factor	NN
cord-006860-a3b8hyyr	394	7	,	,	,
cord-006860-a3b8hyyr	394	8	t	t	NNP
cord-006860-a3b8hyyr	394	9	-	-	HYPH
cord-006860-a3b8hyyr	394	10	PA	PA	NNP
cord-006860-a3b8hyyr	394	11	wa_~	wa_~	NNP
cord-006860-a3b8hyyr	394	12	introduced	introduce	VBD
cord-006860-a3b8hyyr	394	13	,	,	,
cord-006860-a3b8hyyr	394	14	the	the	DT
cord-006860-a3b8hyyr	394	15	number	number	NN
cord-006860-a3b8hyyr	394	16	of	of	IN
cord-006860-a3b8hyyr	394	17	false	false	JJ
cord-006860-a3b8hyyr	394	18	negatives	negative	NNS
cord-006860-a3b8hyyr	394	19	dropped	drop	VBD
cord-006860-a3b8hyyr	394	20	to	to	IN
cord-006860-a3b8hyyr	394	21	21	21	CD
cord-006860-a3b8hyyr	394	22	%	%	NN
cord-006860-a3b8hyyr	394	23	[	[	-LRB-
cord-006860-a3b8hyyr	394	24	i.e.	i.e.	FW
cord-006860-a3b8hyyr	394	25	79	79	CD
cord-006860-a3b8hyyr	394	26	%	%	NN
cord-006860-a3b8hyyr	394	27	(	(	-LRB-
cord-006860-a3b8hyyr	394	28	158/200	158/200	NNP
cord-006860-a3b8hyyr	394	29	)	)	-RRB-
cord-006860-a3b8hyyr	394	30	had	have	VBD
cord-006860-a3b8hyyr	394	31	two	two	CD
cord-006860-a3b8hyyr	394	32	,	,	,
cord-006860-a3b8hyyr	394	33	risk	risk	NN
cord-006860-a3b8hyyr	394	34	factors	factor	NNS
cord-006860-a3b8hyyr	394	35	elevated	elevate	VBN
cord-006860-a3b8hyyr	394	36	]	]	-RRB-
cord-006860-a3b8hyyr	394	37	and	and	CC
cord-006860-a3b8hyyr	394	38	the	the	DT
cord-006860-a3b8hyyr	394	39	number	number	NN
cord-006860-a3b8hyyr	394	40	of	of	IN
cord-006860-a3b8hyyr	394	41	false	false	JJ
cord-006860-a3b8hyyr	394	42	positives	positive	NNS
cord-006860-a3b8hyyr	394	43	to	to	IN
cord-006860-a3b8hyyr	394	44	13	13	CD
cord-006860-a3b8hyyr	394	45	%	%	NN
cord-006860-a3b8hyyr	394	46	To	to	TO
cord-006860-a3b8hyyr	394	47	investigate	investigate	VB
cord-006860-a3b8hyyr	394	48	whether	whether	IN
cord-006860-a3b8hyyr	394	49	a	a	DT
cord-006860-a3b8hyyr	394	50	third	third	JJ
cord-006860-a3b8hyyr	394	51	parameter	parameter	NN
cord-006860-a3b8hyyr	394	52	could	could	MD
cord-006860-a3b8hyyr	394	53	discriminate	discriminate	VB
cord-006860-a3b8hyyr	394	54	further	further	RB
cord-006860-a3b8hyyr	394	55	,	,	,
cord-006860-a3b8hyyr	394	56	PAI	PAI	NNP
cord-006860-a3b8hyyr	394	57	-	-	HYPH
cord-006860-a3b8hyyr	394	58	I	I	NNP
cord-006860-a3b8hyyr	394	59	antigen	antigen	NN
cord-006860-a3b8hyyr	394	60	was	be	VBD
cord-006860-a3b8hyyr	394	61	used	use	VBN
cord-006860-a3b8hyyr	394	62	to	to	TO
cord-006860-a3b8hyyr	394	63	analyse	analyse	VB
cord-006860-a3b8hyyr	394	64	the	the	DT
cord-006860-a3b8hyyr	394	65	rcnudning	rcnudne	VBG
cord-006860-a3b8hyyr	394	66	false	false	JJ
cord-006860-a3b8hyyr	394	67	positives	positive	NNS
cord-006860-a3b8hyyr	394	68	and	and	CC
cord-006860-a3b8hyyr	394	69	negatives	negative	NNS
cord-006860-a3b8hyyr	394	70	.	.	.
cord-006860-a3b8hyyr	395	1	An	an	DT
cord-006860-a3b8hyyr	395	2	additional	additional	JJ
cord-006860-a3b8hyyr	395	3	4	4	CD
cord-006860-a3b8hyyr	395	4	%	%	NN
cord-006860-a3b8hyyr	395	5	could	could	MD
cord-006860-a3b8hyyr	395	6	be	be	VB
cord-006860-a3b8hyyr	395	7	detected	detect	VBN
cord-006860-a3b8hyyr	395	8	,	,	,
cord-006860-a3b8hyyr	395	9	resuhing	resuhe	VBG
cord-006860-a3b8hyyr	395	10	in	in	IN
cord-006860-a3b8hyyr	395	11	83	83	CD
cord-006860-a3b8hyyr	395	12	%	%	NN
cord-006860-a3b8hyyr	395	13	of	of	IN
cord-006860-a3b8hyyr	395	14	the	the	DT
cord-006860-a3b8hyyr	395	15	CHD	CHD	NNP
cord-006860-a3b8hyyr	395	16	group	group	NN
cord-006860-a3b8hyyr	395	17	having	have	VBG
cord-006860-a3b8hyyr	395	18	three	three	CD
cord-006860-a3b8hyyr	395	19	risk	risk	NN
cord-006860-a3b8hyyr	395	20	factors	factor	NNS
cord-006860-a3b8hyyr	395	21	elevated	elevate	VBN
cord-006860-a3b8hyyr	395	22	.	.	.
cord-006860-a3b8hyyr	396	1	Similarly	similarly	RB
cord-006860-a3b8hyyr	396	2	,	,	,
cord-006860-a3b8hyyr	396	3	the	the	DT
cord-006860-a3b8hyyr	396	4	number	number	NN
cord-006860-a3b8hyyr	396	5	of	of	IN
cord-006860-a3b8hyyr	396	6	normal	normal	JJ
cord-006860-a3b8hyyr	396	7	aubjecta	aubjecta	NN
cord-006860-a3b8hyyr	396	8	with	with	IN
cord-006860-a3b8hyyr	396	9	three	three	CD
cord-006860-a3b8hyyr	396	10	parameters	parameter	NNS
cord-006860-a3b8hyyr	396	11	elevated	elevate	VBN
cord-006860-a3b8hyyr	396	12	dropped	drop	VBD
cord-006860-a3b8hyyr	396	13	by	by	IN
cord-006860-a3b8hyyr	396	14	4	4	CD
cord-006860-a3b8hyyr	396	15	%	%	NN
cord-006860-a3b8hyyr	396	16	to	to	TO
cord-006860-a3b8hyyr	396	17	9	9	CD
cord-006860-a3b8hyyr	396	18	%	%	NN
cord-006860-a3b8hyyr	396	19	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	396	20	.	.	.
cord-006860-a3b8hyyr	397	1	when	when	WRB
cord-006860-a3b8hyyr	397	2	a	a	DT
cord-006860-a3b8hyyr	397	3	fourth	fourth	JJ
cord-006860-a3b8hyyr	397	4	parameter	parameter	NN
cord-006860-a3b8hyyr	397	5	was	be	VBD
cord-006860-a3b8hyyr	397	6	introduced	introduce	VBN
cord-006860-a3b8hyyr	397	7	,	,	,
cord-006860-a3b8hyyr	397	8	namely	namely	RB
cord-006860-a3b8hyyr	397	9	PCI	PCI	NNP
cord-006860-a3b8hyyr	397	10	,	,	,
cord-006860-a3b8hyyr	397	11	it	-PRON-	PRP
cord-006860-a3b8hyyr	397	12	was	be	VBD
cord-006860-a3b8hyyr	397	13	round	round	JJ
cord-006860-a3b8hyyr	397	14	to	to	TO
cord-006860-a3b8hyyr	397	15	discriminate	discriminate	VB
cord-006860-a3b8hyyr	397	16	a	a	DT
cord-006860-a3b8hyyr	397	17	further	further	JJ
cord-006860-a3b8hyyr	397	18	8	8	CD
cord-006860-a3b8hyyr	397	19	%	%	NN
cord-006860-a3b8hyyr	397	20	in	in	IN
cord-006860-a3b8hyyr	397	21	the	the	DT
cord-006860-a3b8hyyr	397	22	CHD	CHD	NNP
cord-006860-a3b8hyyr	397	23	group	group	NN
cord-006860-a3b8hyyr	397	24	,	,	,
cord-006860-a3b8hyyr	397	25	thereby	thereby	RB
cord-006860-a3b8hyyr	397	26	increasing	increase	VBG
cord-006860-a3b8hyyr	397	27	tile	tile	NN
cord-006860-a3b8hyyr	397	28	di	di	XX
cord-006860-a3b8hyyr	398	1	~riminalion	~riminalion	NN
cord-006860-a3b8hyyr	398	2	to	to	IN
cord-006860-a3b8hyyr	398	3	91	91	CD
cord-006860-a3b8hyyr	398	4	%	%	NN
cord-006860-a3b8hyyr	398	5	.	.	.
cord-006860-a3b8hyyr	399	1	The	the	DT
cord-006860-a3b8hyyr	399	2	number	number	NN
cord-006860-a3b8hyyr	399	3	of	of	IN
cord-006860-a3b8hyyr	399	4	false	false	JJ
cord-006860-a3b8hyyr	399	5	positives	positive	NNS
cord-006860-a3b8hyyr	399	6	dropped	drop	VBD
cord-006860-a3b8hyyr	399	7	to	to	IN
cord-006860-a3b8hyyr	399	8	4	4	CD
cord-006860-a3b8hyyr	399	9	%	%	NN
cord-006860-a3b8hyyr	399	10	,	,	,
cord-006860-a3b8hyyr	399	11	Additionally	additionally	RB
cord-006860-a3b8hyyr	399	12	,	,	,
cord-006860-a3b8hyyr	399	13	determination	determination	NN
cord-006860-a3b8hyyr	399	14	of	of	IN
cord-006860-a3b8hyyr	399	15	PCI	PCI	NNP
cord-006860-a3b8hyyr	399	16	increased	increase	VBD
cord-006860-a3b8hyyr	399	17	the	the	DT
cord-006860-a3b8hyyr	399	18	discrimination	discrimination	NN
cord-006860-a3b8hyyr	399	19	of	of	IN
cord-006860-a3b8hyyr	399	20	patienta	patienta	NNP
cord-006860-a3b8hyyr	399	21	having	have	VBG
cord-006860-a3b8hyyr	399	22	had	have	VBN
cord-006860-a3b8hyyr	399	23	multiple	multiple	JJ
cord-006860-a3b8hyyr	399	24	infarctions	infarction	NNS
cord-006860-a3b8hyyr	399	25	from	from	IN
cord-006860-a3b8hyyr	399	26	88	88	CD
cord-006860-a3b8hyyr	399	27	°	°	NN
cord-006860-a3b8hyyr	399	28	/=	/=	NN
cord-006860-a3b8hyyr	399	29	when	when	WRB
cord-006860-a3b8hyyr	399	30	thrce	thrce	NN
cord-006860-a3b8hyyr	399	31	parameters	parameter	NNS
cord-006860-a3b8hyyr	399	32	were	be	VBD
cord-006860-a3b8hyyr	399	33	mcasured	mcasure	VBN
cord-006860-a3b8hyyr	399	34	to	to	IN
cord-006860-a3b8hyyr	399	35	100	100	CD
cord-006860-a3b8hyyr	399	36	%	%	NN
cord-006860-a3b8hyyr	399	37	.	.	.
cord-006860-a3b8hyyr	400	1	From	from	IN
cord-006860-a3b8hyyr	400	2	these	these	DT
cord-006860-a3b8hyyr	400	3	results	result	NNS
cord-006860-a3b8hyyr	400	4	it	-PRON-	PRP
cord-006860-a3b8hyyr	400	5	can	can	MD
cord-006860-a3b8hyyr	400	6	be	be	VB
cord-006860-a3b8hyyr	400	7	concloded	conclode	VBN
cord-006860-a3b8hyyr	400	8	that	that	IN
cord-006860-a3b8hyyr	400	9	determination	determination	NN
cord-006860-a3b8hyyr	400	10	of	of	IN
cord-006860-a3b8hyyr	400	11	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	400	12	levels	level	NNS
cord-006860-a3b8hyyr	400	13	alone	alone	RB
cord-006860-a3b8hyyr	400	14	is	be	VBZ
cord-006860-a3b8hyyr	400	15	not	not	RB
cord-006860-a3b8hyyr	400	16	sumcicnt	sumcicnt	JJ
cord-006860-a3b8hyyr	400	17	to	to	TO
cord-006860-a3b8hyyr	400	18	separate	separate	JJ
cord-006860-a3b8hyyr	400	19	patients	patient	NNS
cord-006860-a3b8hyyr	400	20	from	from	IN
cord-006860-a3b8hyyr	400	21	controls	control	NNS
cord-006860-a3b8hyyr	400	22	as	as	IN
cord-006860-a3b8hyyr	400	23	t	t	NNP
cord-006860-a3b8hyyr	400	24	-	-	HYPH
cord-006860-a3b8hyyr	400	25	PA	PA	NNP
cord-006860-a3b8hyyr	400	26	adds	add	VBZ
cord-006860-a3b8hyyr	400	27	significant	significant	JJ
cord-006860-a3b8hyyr	400	28	discrimination	discrimination	NN
cord-006860-a3b8hyyr	400	29	.	.	.
cord-006860-a3b8hyyr	401	1	PAI	PAI	NNP
cord-006860-a3b8hyyr	401	2	-	-	HYPH
cord-006860-a3b8hyyr	401	3	I	i	NN
cord-006860-a3b8hyyr	401	4	antigen	antigen	NN
cord-006860-a3b8hyyr	401	5	which	which	WDT
cord-006860-a3b8hyyr	401	6	correlated	correlate	VBD
cord-006860-a3b8hyyr	401	7	strongly	strongly	RB
cord-006860-a3b8hyyr	401	8	with	with	IN
cord-006860-a3b8hyyr	401	9	t	t	NNP
cord-006860-a3b8hyyr	401	10	-	-	HYPH
cord-006860-a3b8hyyr	401	11	PA	PA	NNP
cord-006860-a3b8hyyr	401	12	did	do	VBD
cord-006860-a3b8hyyr	401	13	not	not	RB
cord-006860-a3b8hyyr	401	14	significantly	significantly	RB
cord-006860-a3b8hyyr	401	15	increase	increase	VB
cord-006860-a3b8hyyr	401	16	the	the	DT
cord-006860-a3b8hyyr	401	17	discriminatory	discriminatory	JJ
cord-006860-a3b8hyyr	401	18	potential	potential	NN
cord-006860-a3b8hyyr	401	19	of	of	IN
cord-006860-a3b8hyyr	401	20	both	both	DT
cord-006860-a3b8hyyr	401	21	Fg	Fg	NNP
cord-006860-a3b8hyyr	401	22	and	and	CC
cord-006860-a3b8hyyr	401	23	I	I	NNP
cord-006860-a3b8hyyr	401	24	-	-	HYPH
cord-006860-a3b8hyyr	401	25	PA	PA	NNP
cord-006860-a3b8hyyr	401	26	.	.	.
cord-006860-a3b8hyyr	402	1	However	however	RB
cord-006860-a3b8hyyr	402	2	,	,	,
cord-006860-a3b8hyyr	402	3	by	by	IN
cord-006860-a3b8hyyr	402	4	employing	employ	VBG
cord-006860-a3b8hyyr	402	5	PCI	PCI	NNP
cord-006860-a3b8hyyr	402	6	as	as	IN
cord-006860-a3b8hyyr	402	7	a	a	DT
cord-006860-a3b8hyyr	402	8	fourth	fourth	JJ
cord-006860-a3b8hyyr	402	9	paramctcr	paramctcr	NN
cord-006860-a3b8hyyr	402	10	,	,	,
cord-006860-a3b8hyyr	402	11	virtually	virtually	RB
cord-006860-a3b8hyyr	402	12	complete	complete	JJ
cord-006860-a3b8hyyr	402	13	separation	separation	NN
cord-006860-a3b8hyyr	402	14	between	between	IN
cord-006860-a3b8hyyr	402	15	the	the	DT
cord-006860-a3b8hyyr	402	16	CHD	chd	NN
cord-006860-a3b8hyyr	402	17	and	and	CC
cord-006860-a3b8hyyr	402	18	normal	normal	JJ
cord-006860-a3b8hyyr	402	19	groups	group	NNS
cord-006860-a3b8hyyr	402	20	as	as	RB
cord-006860-a3b8hyyr	402	21	well	well	RB
cord-006860-a3b8hyyr	402	22	as	as	IN
cord-006860-a3b8hyyr	402	23	rurthcr	rurthcr	NNP
cord-006860-a3b8hyyr	402	24	recoguitiou	recoguitiou	NNP
cord-006860-a3b8hyyr	402	25	of	of	IN
cord-006860-a3b8hyyr	402	26	'	'	``
cord-006860-a3b8hyyr	402	27	patients	patient	NNS
cord-006860-a3b8hyyr	402	28	having	have	VBG
cord-006860-a3b8hyyr	402	29	had	have	VBN
cord-006860-a3b8hyyr	402	30	multiple	multiple	JJ
cord-006860-a3b8hyyr	402	31	infarctions	infarction	NNS
cord-006860-a3b8hyyr	402	32	could	could	MD
cord-006860-a3b8hyyr	402	33	be	be	VB
cord-006860-a3b8hyyr	402	34	obtained	obtain	VBN
cord-006860-a3b8hyyr	402	35	.	.	.
cord-006860-a3b8hyyr	403	1	To	to	TO
cord-006860-a3b8hyyr	403	2	test	test	VB
cord-006860-a3b8hyyr	403	3	the	the	DT
cord-006860-a3b8hyyr	403	4	hypothesis	hypothesis	NN
cord-006860-a3b8hyyr	403	5	that	that	IN
cord-006860-a3b8hyyr	403	6	oral	oral	JJ
cord-006860-a3b8hyyr	403	7	contraceptives	contraceptive	NNS
cord-006860-a3b8hyyr	403	8	(	(	-LRB-
cord-006860-a3b8hyyr	403	9	OC	OC	NNP
cord-006860-a3b8hyyr	403	10	)	)	-RRB-
cord-006860-a3b8hyyr	403	11	enhance	enhance	VB
cord-006860-a3b8hyyr	403	12	exercise	exercise	NN
cord-006860-a3b8hyyr	403	13	-	-	HYPH
cord-006860-a3b8hyyr	403	14	induced	induce	VBN
cord-006860-a3b8hyyr	403	15	activation	activation	NN
cord-006860-a3b8hyyr	403	16	of	of	IN
cord-006860-a3b8hyyr	403	17	blood	blood	NN
cord-006860-a3b8hyyr	403	18	coagulation	coagulation	NN
cord-006860-a3b8hyyr	403	19	we	-PRON-	PRP
cord-006860-a3b8hyyr	403	20	examined	examine	VBD
cord-006860-a3b8hyyr	403	21	11	11	CD
cord-006860-a3b8hyyr	403	22	women	woman	NNS
cord-006860-a3b8hyyr	403	23	(	(	-LRB-
cord-006860-a3b8hyyr	403	24	27	27	CD
cord-006860-a3b8hyyr	403	25	+	+	SYM
cord-006860-a3b8hyyr	403	26	3	3	CD
cord-006860-a3b8hyyr	403	27	(	(	-LRB-
cord-006860-a3b8hyyr	403	28	SD	SD	NNP
cord-006860-a3b8hyyr	403	29	)	)	-RRB-
cord-006860-a3b8hyyr	403	30	years	year	NNS
cord-006860-a3b8hyyr	403	31	,	,	,
cord-006860-a3b8hyyr	403	32	BMI	BMI	NNP
cord-006860-a3b8hyyr	403	33	20.4	20.4	CD
cord-006860-a3b8hyyr	403	34	+	+	CC
cord-006860-a3b8hyyr	404	1	2.0	2.0	CD
cord-006860-a3b8hyyr	404	2	kg	kg	NN
cord-006860-a3b8hyyr	404	3	/	/	SYM
cord-006860-a3b8hyyr	404	4	m	m	NN
cord-006860-a3b8hyyr	404	5	2	2	CD
cord-006860-a3b8hyyr	404	6	,	,	,
cord-006860-a3b8hyyr	404	7	VOzm	VOzm	NNP
cord-006860-a3b8hyyr	404	8	..	..	.
cord-006860-a3b8hyyr	405	1	49	49	CD
cord-006860-a3b8hyyr	405	2	+	+	SYM
cord-006860-a3b8hyyr	405	3	7	7	CD
cord-006860-a3b8hyyr	405	4	ml	ml	NN
cord-006860-a3b8hyyr	405	5	/	/	SYM
cord-006860-a3b8hyyr	405	6	kg	kg	NNP
cord-006860-a3b8hyyr	405	7	/	/	SYM
cord-006860-a3b8hyyr	405	8	min	min	NN
cord-006860-a3b8hyyr	405	9	)	)	-RRB-
cord-006860-a3b8hyyr	405	10	without	without	IN
cord-006860-a3b8hyyr	405	11	OC	OC	NNP
cord-006860-a3b8hyyr	405	12	between	between	IN
cord-006860-a3b8hyyr	405	13	day	day	NN
cord-006860-a3b8hyyr	405	14	18	18	CD
cord-006860-a3b8hyyr	405	15	and	and	CC
cord-006860-a3b8hyyr	405	16	22	22	CD
cord-006860-a3b8hyyr	405	17	of	of	IN
cord-006860-a3b8hyyr	405	18	the	the	DT
cord-006860-a3b8hyyr	405	19	menstrual	menstrual	JJ
cord-006860-a3b8hyyr	405	20	cycle	cycle	NN
cord-006860-a3b8hyyr	405	21	and	and	CC
cord-006860-a3b8hyyr	405	22	10	10	CD
cord-006860-a3b8hyyr	405	23	women	woman	NNS
cord-006860-a3b8hyyr	405	24	(	(	-LRB-
cord-006860-a3b8hyyr	405	25	24	24	CD
cord-006860-a3b8hyyr	405	26	+	+	SYM
cord-006860-a3b8hyyr	405	27	2	2	CD
cord-006860-a3b8hyyr	405	28	(	(	-LRB-
cord-006860-a3b8hyyr	405	29	SD	sd	NN
cord-006860-a3b8hyyr	405	30	)	)	-RRB-
cord-006860-a3b8hyyr	405	31	years	year	NNS
cord-006860-a3b8hyyr	405	32	,	,	,
cord-006860-a3b8hyyr	405	33	BMI	BMI	NNP
cord-006860-a3b8hyyr	405	34	20,6	20,6	CD
cord-006860-a3b8hyyr	405	35	±	±	NN
cord-006860-a3b8hyyr	405	36	1,6	1,6	CD
cord-006860-a3b8hyyr	405	37	kg	kg	NNP
cord-006860-a3b8hyyr	405	38	/	/	SYM
cord-006860-a3b8hyyr	405	39	m	m	NNP
cord-006860-a3b8hyyr	405	40	'	'	''
cord-006860-a3b8hyyr	405	41	,	,	.
cord-006860-a3b8hyyr	406	1	VO2max	VO2max	NNP
cord-006860-a3b8hyyr	406	2	47	47	CD
cord-006860-a3b8hyyr	406	3	+	+	SYM
cord-006860-a3b8hyyr	406	4	7	7	CD
cord-006860-a3b8hyyr	406	5	ml	ml	NN
cord-006860-a3b8hyyr	406	6	/	/	SYM
cord-006860-a3b8hyyr	406	7	kg	kg	NNP
cord-006860-a3b8hyyr	406	8	/	/	SYM
cord-006860-a3b8hyyr	406	9	min	min	NN
cord-006860-a3b8hyyr	406	10	)	)	-RRB-
cord-006860-a3b8hyyr	407	1	taking	take	VBG
cord-006860-a3b8hyyr	407	2	OC	OC	NNP
cord-006860-a3b8hyyr	408	1	(	(	-LRB-
cord-006860-a3b8hyyr	408	2	150	150	CD
cord-006860-a3b8hyyr	408	3	mg	mg	NNP
cord-006860-a3b8hyyr	408	4	Desogestrel	Desogestrel	NNP
cord-006860-a3b8hyyr	408	5	and	and	CC
cord-006860-a3b8hyyr	408	6	30	30	CD
cord-006860-a3b8hyyr	408	7	mg	mg	NNP
cord-006860-a3b8hyyr	408	8	Ethinylestradiol	Ethinylestradiol	NNP
cord-006860-a3b8hyyr	408	9	)	)	-RRB-
cord-006860-a3b8hyyr	408	10	between	between	IN
cord-006860-a3b8hyyr	408	11	day	day	NN
cord-006860-a3b8hyyr	408	12	7	7	CD
cord-006860-a3b8hyyr	408	13	and	and	CC
cord-006860-a3b8hyyr	408	14	21	21	CD
cord-006860-a3b8hyyr	408	15	of	of	IN
cord-006860-a3b8hyyr	408	16	drug	drug	NN
cord-006860-a3b8hyyr	408	17	intake	intake	NN
cord-006860-a3b8hyyr	408	18	.	.	.
cord-006860-a3b8hyyr	409	1	Prothrombin	Prothrombin	NNP
cord-006860-a3b8hyyr	409	2	fragment	fragment	NN
cord-006860-a3b8hyyr	409	3	1	1	CD
cord-006860-a3b8hyyr	409	4	+2	+2	CD
cord-006860-a3b8hyyr	410	1	(	(	-LRB-
cord-006860-a3b8hyyr	410	2	PTF1	PTF1	NNP
cord-006860-a3b8hyyr	410	3	+	+	SYM
cord-006860-a3b8hyyr	410	4	2	2	CD
cord-006860-a3b8hyyr	410	5	)	)	-RRB-
cord-006860-a3b8hyyr	410	6	and	and	CC
cord-006860-a3b8hyyr	410	7	fibrtnopeptide	fibrtnopeptide	VB
cord-006860-a3b8hyyr	410	8	A	a	DT
cord-006860-a3b8hyyr	410	9	(	(	-LRB-
cord-006860-a3b8hyyr	410	10	FPA	FPA	NNP
cord-006860-a3b8hyyr	410	11	)	)	-RRB-
cord-006860-a3b8hyyr	410	12	were	be	VBD
cord-006860-a3b8hyyr	410	13	measured	measure	VBN
cord-006860-a3b8hyyr	410	14	before	before	RB
cord-006860-a3b8hyyr	410	15	and	and	CC
cord-006860-a3b8hyyr	410	16	after	after	IN
cord-006860-a3b8hyyr	410	17	running	run	VBG
cord-006860-a3b8hyyr	410	18	for	for	IN
cord-006860-a3b8hyyr	410	19	one	one	CD
cord-006860-a3b8hyyr	410	20	hour	hour	NN
cord-006860-a3b8hyyr	410	21	on	on	IN
cord-006860-a3b8hyyr	410	22	a	a	DT
cord-006860-a3b8hyyr	410	23	treadmill	treadmill	NN
cord-006860-a3b8hyyr	410	24	at	at	IN
cord-006860-a3b8hyyr	410	25	a	a	DT
cord-006860-a3b8hyyr	410	26	speed	speed	NN
cord-006860-a3b8hyyr	410	27	corresponding	correspond	VBG
cord-006860-a3b8hyyr	410	28	to	to	IN
cord-006860-a3b8hyyr	410	29	the	the	DT
cord-006860-a3b8hyyr	410	30	anaerobic	anaerobic	JJ
cord-006860-a3b8hyyr	410	31	threshold	threshold	NN
cord-006860-a3b8hyyr	410	32	.	.	.
cord-006860-a3b8hyyr	411	1	Mean	mean	JJ
cord-006860-a3b8hyyr	411	2	heart	heart	NN
cord-006860-a3b8hyyr	411	3	rate	rate	NN
cord-006860-a3b8hyyr	411	4	[	[	-LRB-
cord-006860-a3b8hyyr	411	5	191	191	CD
cord-006860-a3b8hyyr	411	6	±	±	NNP
cord-006860-a3b8hyyr	411	7	10	10	CD
cord-006860-a3b8hyyr	411	8	vs.	vs.	NN
cord-006860-a3b8hyyr	411	9	196	196	CD
cord-006860-a3b8hyyr	411	10	±	±	CD
cord-006860-a3b8hyyr	411	11	12	12	CD
cord-006860-a3b8hyyr	411	12	min	min	NN
cord-006860-a3b8hyyr	411	13	1	1	CD
cord-006860-a3b8hyyr	411	14	)	)	-RRB-
cord-006860-a3b8hyyr	411	15	and	and	CC
cord-006860-a3b8hyyr	411	16	mean	mean	VB
cord-006860-a3b8hyyr	411	17	plasma	plasma	NN
cord-006860-a3b8hyyr	411	18	lactate	lactate	NN
cord-006860-a3b8hyyr	411	19	(	(	-LRB-
cord-006860-a3b8hyyr	411	20	3.3	3.3	CD
cord-006860-a3b8hyyr	411	21	±	±	CD
cord-006860-a3b8hyyr	411	22	1.6	1.6	CD
cord-006860-a3b8hyyr	411	23	vs.	vs.	IN
cord-006860-a3b8hyyr	411	24	3.1	3.1	CD
cord-006860-a3b8hyyr	411	25	+	+	SYM
cord-006860-a3b8hyyr	411	26	1.2	1.2	CD
cord-006860-a3b8hyyr	411	27	mmot	mmot	NNP
cord-006860-a3b8hyyr	411	28	/	/	,
cord-006860-a3b8hyyr	411	29	I	i	NN
cord-006860-a3b8hyyr	411	30	)	)	-RRB-
cord-006860-a3b8hyyr	411	31	wera	wera	VBP
cord-006860-a3b8hyyr	411	32	comparable	comparable	JJ
cord-006860-a3b8hyyr	411	33	during	during	IN
cord-006860-a3b8hyyr	411	34	exercise	exercise	NN
cord-006860-a3b8hyyr	411	35	between	between	IN
cord-006860-a3b8hyyr	411	36	control	control	NN
cord-006860-a3b8hyyr	411	37	and	and	CC
cord-006860-a3b8hyyr	411	38	OC	OC	NNP
cord-006860-a3b8hyyr	411	39	group	group	NN
cord-006860-a3b8hyyr	411	40	,	,	,
cord-006860-a3b8hyyr	411	41	respectively	respectively	RB
cord-006860-a3b8hyyr	411	42	.	.	.
cord-006860-a3b8hyyr	412	1	Results	result	NNS
cord-006860-a3b8hyyr	412	2	for	for	IN
cord-006860-a3b8hyyr	412	3	markers	marker	NNS
cord-006860-a3b8hyyr	412	4	of	of	IN
cord-006860-a3b8hyyr	412	5	thrombin	thrombin	NN
cord-006860-a3b8hyyr	412	6	and	and	CC
cord-006860-a3b8hyyr	412	7	fibrin	fibrin	NN
cord-006860-a3b8hyyr	412	8	formation	formation	NN
cord-006860-a3b8hyyr	412	9	were	be	VBD
cord-006860-a3b8hyyr	412	10	:	:	:
cord-006860-a3b8hyyr	412	11	PTF1	PTF1	NNP
cord-006860-a3b8hyyr	413	1	+2	+2	LS
cord-006860-a3b8hyyr	413	2	(	(	-LRB-
cord-006860-a3b8hyyr	413	3	nmol	nmol	NNP
cord-006860-a3b8hyyr	413	4	/	/	,
cord-006860-a3b8hyyr	413	5	I	i	NN
cord-006860-a3b8hyyr	413	6	)	)	-RRB-
cord-006860-a3b8hyyr	413	7	FPA	FPA	NNP
cord-006860-a3b8hyyr	413	8	(	(	-LRB-
cord-006860-a3b8hyyr	413	9	ng	ng	NNP
cord-006860-a3b8hyyr	413	10	/	/	SYM
cord-006860-a3b8hyyr	413	11	ml	ml	NN
cord-006860-a3b8hyyr	413	12	)	)	-RRB-
cord-006860-a3b8hyyr	413	13	control	control	NN
cord-006860-a3b8hyyr	413	14	before	before	IN
cord-006860-a3b8hyyr	413	15	0,66	0,66	CD
cord-006860-a3b8hyyr	413	16	±	±	CD
cord-006860-a3b8hyyr	413	17	0.19	0.19	CD
cord-006860-a3b8hyyr	413	18	1.0	1.0	CD
cord-006860-a3b8hyyr	413	19	+	+	SYM
cord-006860-a3b8hyyr	413	20	0.2	0.2	CD
cord-006860-a3b8hyyr	413	21	after	after	IN
cord-006860-a3b8hyyr	413	22	0.73	0.73	CD
cord-006860-a3b8hyyr	413	23	+	+	SYM
cord-006860-a3b8hyyr	413	24	0.23	0.23	CD
cord-006860-a3b8hyyr	413	25	2.2	2.2	CD
cord-006860-a3b8hyyr	413	26	+	+	SYM
cord-006860-a3b8hyyr	413	27	1.2	1.2	CD
cord-006860-a3b8hyyr	413	28	"	"	''
cord-006860-a3b8hyyr	413	29	OC	OC	NNP
cord-006860-a3b8hyyr	413	30	before	before	RB
cord-006860-a3b8hyyr	413	31	0.82	0.82	CD
cord-006860-a3b8hyyr	413	32	+	+	SYM
cord-006860-a3b8hyyr	413	33	0.31	0.31	CD
cord-006860-a3b8hyyr	413	34	1.0	1.0	CD
cord-006860-a3b8hyyr	414	1	+	+	SYM
cord-006860-a3b8hyyr	414	2	0.2	0.2	CD
cord-006860-a3b8hyyr	414	3	after	after	IN
cord-006860-a3b8hyyr	414	4	1.11	1.11	CD
cord-006860-a3b8hyyr	414	5	+	+	SYM
cord-006860-a3b8hyyr	414	6	0.48	0.48	CD
cord-006860-a3b8hyyr	415	1	*	*	NFP
cord-006860-a3b8hyyr	415	2	+	+	SYM
cord-006860-a3b8hyyr	415	3	5.8	5.8	CD
cord-006860-a3b8hyyr	415	4	-+	-+	.
cord-006860-a3b8hyyr	415	5	6.0	6.0	CD
cord-006860-a3b8hyyr	416	1	*	*	NFP
cord-006860-a3b8hyyr	416	2	+	+	CC
cord-006860-a3b8hyyr	417	1	*	*	NFP
cord-006860-a3b8hyyr	417	2	p	p	XX
cord-006860-a3b8hyyr	417	3	<	<	XX
cord-006860-a3b8hyyr	417	4	0.05	0.05	CD
cord-006860-a3b8hyyr	417	5	vs.	vs.	IN
cord-006860-a3b8hyyr	417	6	baseline	baseline	NN
cord-006860-a3b8hyyr	417	7	,	,	,
cord-006860-a3b8hyyr	417	8	+	+	CC
cord-006860-a3b8hyyr	417	9	p	p	NN
cord-006860-a3b8hyyr	417	10	<	<	XX
cord-006860-a3b8hyyr	417	11	0.05	0.05	CD
cord-006860-a3b8hyyr	417	12	between	between	IN
cord-006860-a3b8hyyr	417	13	groups	group	NNS
cord-006860-a3b8hyyr	417	14	.	.	.
cord-006860-a3b8hyyr	418	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	418	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	418	3	that	that	IN
cord-006860-a3b8hyyr	418	4	oral	oral	JJ
cord-006860-a3b8hyyr	418	5	contraception	contraception	NN
cord-006860-a3b8hyyr	418	6	with	with	IN
cord-006860-a3b8hyyr	418	7	150	150	CD
cord-006860-a3b8hyyr	418	8	mg	mg	NNP
cord-006860-a3b8hyyr	418	9	Desogestrel	Desogestrel	NNP
cord-006860-a3b8hyyr	418	10	and	and	CC
cord-006860-a3b8hyyr	418	11	30	30	CD
cord-006860-a3b8hyyr	418	12	mg	mg	NNP
cord-006860-a3b8hyyr	418	13	Ethinylestradiol	Ethinylestradiol	NNP
cord-006860-a3b8hyyr	418	14	enhances	enhance	VBZ
cord-006860-a3b8hyyr	418	15	exercise	exercise	NN
cord-006860-a3b8hyyr	418	16	-	-	HYPH
cord-006860-a3b8hyyr	418	17	induced	induce	VBN
cord-006860-a3b8hyyr	418	18	thrombin	thrombin	NN
cord-006860-a3b8hyyr	418	19	and	and	CC
cord-006860-a3b8hyyr	418	20	fibrin	fibrin	NN
cord-006860-a3b8hyyr	418	21	formation	formation	NN
cord-006860-a3b8hyyr	418	22	,	,	,
cord-006860-a3b8hyyr	418	23	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	418	24	data	datum	NNS
cord-006860-a3b8hyyr	418	25	suggest	suggest	VBP
cord-006860-a3b8hyyr	418	26	that	that	IN
cord-006860-a3b8hyyr	418	27	exercise	exercise	NN
cord-006860-a3b8hyyr	418	28	testing	testing	NN
cord-006860-a3b8hyyr	418	29	might	may	MD
cord-006860-a3b8hyyr	418	30	be	be	VB
cord-006860-a3b8hyyr	418	31	useful	useful	JJ
cord-006860-a3b8hyyr	418	32	for	for	IN
cord-006860-a3b8hyyr	418	33	evaluating	evaluate	VBG
cord-006860-a3b8hyyr	418	34	the	the	DT
cord-006860-a3b8hyyr	418	35	risk	risk	NN
cord-006860-a3b8hyyr	418	36	of	of	IN
cord-006860-a3b8hyyr	418	37	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	418	38	associated	associate	VBN
cord-006860-a3b8hyyr	418	39	with	with	IN
cord-006860-a3b8hyyr	418	40	different	different	JJ
cord-006860-a3b8hyyr	418	41	compositions	composition	NNS
cord-006860-a3b8hyyr	418	42	of	of	IN
cord-006860-a3b8hyyr	418	43	OC	OC	NNP
cord-006860-a3b8hyyr	418	44	.	.	.
cord-006860-a3b8hyyr	419	1	A.	A.	NNP
cord-006860-a3b8hyyr	419	2	Haushofer	Haushofer	NNP
cord-006860-a3b8hyyr	419	3	+	+	NNP
cord-006860-a3b8hyyr	419	4	,	,	,
cord-006860-a3b8hyyr	419	5	WM	WM	NNP
cord-006860-a3b8hyyr	419	6	.	.	.
cord-006860-a3b8hyyr	420	1	Halbmayer	Halbmayer	NNP
cord-006860-a3b8hyyr	420	2	+	+	CC
cord-006860-a3b8hyyr	420	3	,	,	,
cord-006860-a3b8hyyr	420	4	J.	J.	NNP
cord-006860-a3b8hyyr	420	5	Radek	Radek	NNP
cord-006860-a3b8hyyr	420	6	+	+	CC
cord-006860-a3b8hyyr	420	7	,	,	.
cord-006860-a3b8hyyr	421	1	M.	M.	NNP
cord-006860-a3b8hyyr	421	2	Dittel	Dittel	NNP
cord-006860-a3b8hyyr	421	3	*	*	NFP
cord-006860-a3b8hyyr	421	4	,	,	,
cord-006860-a3b8hyyr	421	5	R.	R.	NNP
cord-006860-a3b8hyyr	421	6	Spiel	Spiel	NNP
cord-006860-a3b8hyyr	421	7	*	*	NFP
cord-006860-a3b8hyyr	421	8	,	,	,
cord-006860-a3b8hyyr	421	9	H	H	NNP
cord-006860-a3b8hyyr	421	10	Prachar	Prachar	NNP
cord-006860-a3b8hyyr	421	11	*	*	NFP
cord-006860-a3b8hyyr	421	12	,	,	,
cord-006860-a3b8hyyr	421	13	J.	J.	NNP
cord-006860-a3b8hyyr	421	14	Mtczoch	Mtczoch	NNP
cord-006860-a3b8hyyr	421	15	*	*	NFP
cord-006860-a3b8hyyr	421	16	,	,	,
cord-006860-a3b8hyyr	421	17	M.	M.	NNP
cord-006860-a3b8hyyr	421	18	Fischer	Fischer	NNP
cord-006860-a3b8hyyr	421	19	+	+	CC
cord-006860-a3b8hyyr	422	1	+	+	CC
cord-006860-a3b8hyyr	423	1	Zentraltaboratorium	Zentraltaboratorium	NNP
cord-006860-a3b8hyyr	423	2	mit	mit	NNP
cord-006860-a3b8hyyr	423	3	Thrombose	Thrombose	NNP
cord-006860-a3b8hyyr	423	4	-	-	HYPH
cord-006860-a3b8hyyr	423	5	und	und	NNP
cord-006860-a3b8hyyr	423	6	C	c	NN
cord-006860-a3b8hyyr	424	1	~rinnungsambulanz	~rinnungsambulanz	XX
cord-006860-a3b8hyyr	424	2	-Krankenhaus	-Krankenhaus	NNP
cord-006860-a3b8hyyr	424	3	Lai~	lai~	NN
cord-006860-a3b8hyyr	424	4	:	:	:
cord-006860-a3b8hyyr	425	1	*	*	NFP
cord-006860-a3b8hyyr	425	2	4	4	CD
cord-006860-a3b8hyyr	425	3	.	.	.
cord-006860-a3b8hyyr	426	1	Medizinische	Medizinische	NNP
cord-006860-a3b8hyyr	426	2	Ab[eilung	Ab[eilung	NNP
cord-006860-a3b8hyyr	427	1	mtt	mtt	NNP
cord-006860-a3b8hyyr	427	2	Ka	Ka	NNP
cord-006860-a3b8hyyr	428	1	~	~	NFP
cord-006860-a3b8hyyr	429	1	liolo$i¢	liolo$i¢	NNP
cord-006860-a3b8hyyr	429	2	-Krankenhaus	-Krankenhaus	NNP
cord-006860-a3b8hyyr	429	3	Lainz	Lainz	NNP
cord-006860-a3b8hyyr	429	4	und	und	XX
cord-006860-a3b8hyyr	430	1	Ludwig	Ludwig	NNP
cord-006860-a3b8hyyr	430	2	Bottzmann	Bottzmann	NNP
cord-006860-a3b8hyyr	430	3	-	-	HYPH
cord-006860-a3b8hyyr	430	4	lnstitut	lnstitut	NNP
cord-006860-a3b8hyyr	430	5	ftlr	ftlr	NNP
cord-006860-a3b8hyyr	430	6	Herzinfarktforsohung	Herzinfarktforsohung	NNP
cord-006860-a3b8hyyr	430	7	,	,	,
cord-006860-a3b8hyyr	430	8	Wien	Wien	NNP
cord-006860-a3b8hyyr	430	9	Fifty	Fifty	NNP
cord-006860-a3b8hyyr	430	10	-	-	HYPH
cord-006860-a3b8hyyr	430	11	one	one	CD
cord-006860-a3b8hyyr	430	12	patients	patient	NNS
cord-006860-a3b8hyyr	430	13	(	(	-LRB-
cord-006860-a3b8hyyr	430	14	age	age	NN
cord-006860-a3b8hyyr	430	15	61.6	61.6	CD
cord-006860-a3b8hyyr	430	16	±	±	CD
cord-006860-a3b8hyyr	430	17	9.2a	9.2a	CD
cord-006860-a3b8hyyr	430	18	;	;	:
cord-006860-a3b8hyyr	430	19	34	34	CD
cord-006860-a3b8hyyr	430	20	m	m	NN
cord-006860-a3b8hyyr	430	21	/	/	SYM
cord-006860-a3b8hyyr	430	22	171	171	CD
cord-006860-a3b8hyyr	430	23	)	)	-RRB-
cord-006860-a3b8hyyr	430	24	implanted	implant	VBN
cord-006860-a3b8hyyr	430	25	with	with	IN
cord-006860-a3b8hyyr	430	26	74	74	CD
cord-006860-a3b8hyyr	430	27	coronary	coronary	NN
cord-006860-a3b8hyyr	430	28	stems	stem	VBZ
cord-006860-a3b8hyyr	430	29	03	03	CD
cord-006860-a3b8hyyr	431	1	Palm~-Schatz	palm~-schatz	UH
cord-006860-a3b8hyyr	431	2	,	,	,
cord-006860-a3b8hyyr	432	1	27	27	CD
cord-006860-a3b8hyyr	432	2	Gianturco	Gianturco	NNP
cord-006860-a3b8hyyr	432	3	-	-	HYPH
cord-006860-a3b8hyyr	432	4	Roubin	Roubin	NNP
cord-006860-a3b8hyyr	432	5	,	,	,
cord-006860-a3b8hyyr	432	6	14	14	CD
cord-006860-a3b8hyyr	432	7	Micro	Micro	NNP
cord-006860-a3b8hyyr	432	8	Stcnts	Stcnts	NNP
cord-006860-a3b8hyyr	432	9	)	)	-RRB-
cord-006860-a3b8hyyr	432	10	received	receive	VBD
cord-006860-a3b8hyyr	432	11	a	a	DT
cord-006860-a3b8hyyr	432	12	now	now	RB
cord-006860-a3b8hyyr	432	13	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	432	14	treatment	treatment	NN
cord-006860-a3b8hyyr	432	15	using	use	VBG
cord-006860-a3b8hyyr	432	16	a	a	DT
cord-006860-a3b8hyyr	432	17	combination	combination	NN
cord-006860-a3b8hyyr	432	18	of	of	IN
cord-006860-a3b8hyyr	432	19	Ti¢lopidine	Ti¢lopidine	NNP
cord-006860-a3b8hyyr	432	20	(	(	-LRB-
cord-006860-a3b8hyyr	432	21	TIC	TIC	NNP
cord-006860-a3b8hyyr	432	22	)	)	-RRB-
cord-006860-a3b8hyyr	432	23	2	2	CD
cord-006860-a3b8hyyr	432	24	×250	×250	CD
cord-006860-a3b8hyyr	432	25	mg	mg	NNP
cord-006860-a3b8hyyr	432	26	/	/	SYM
cord-006860-a3b8hyyr	432	27	d	d	NN
cord-006860-a3b8hyyr	432	28	for	for	IN
cord-006860-a3b8hyyr	432	29	28	28	CD
cord-006860-a3b8hyyr	432	30	days	day	NNS
cord-006860-a3b8hyyr	432	31	and	and	CC
cord-006860-a3b8hyyr	432	32	acetyl	acetyl	NN
cord-006860-a3b8hyyr	432	33	salicylic	salicylic	NN
cord-006860-a3b8hyyr	432	34	acid	acid	NN
cord-006860-a3b8hyyr	432	35	(	(	-LRB-
cord-006860-a3b8hyyr	432	36	ASA	ASA	NNP
cord-006860-a3b8hyyr	432	37	)	)	-RRB-
cord-006860-a3b8hyyr	433	1	ZOO	zoo	NN
cord-006860-a3b8hyyr	434	1	mg	mg	NNP
cord-006860-a3b8hyyr	434	2	/	/	SYM
cord-006860-a3b8hyyr	434	3	d	d	NNP
cord-006860-a3b8hyyr	434	4	for	for	IN
cord-006860-a3b8hyyr	434	5	long	long	JJ
cord-006860-a3b8hyyr	434	6	-	-	HYPH
cord-006860-a3b8hyyr	434	7	term	term	NN
cord-006860-a3b8hyyr	434	8	treatment	treatment	NN
cord-006860-a3b8hyyr	434	9	.	.	.
cord-006860-a3b8hyyr	435	1	Patients	patient	NNS
cord-006860-a3b8hyyr	435	2	(	(	-LRB-
cord-006860-a3b8hyyr	435	3	PAT	PAT	NNP
cord-006860-a3b8hyyr	435	4	)	)	-RRB-
cord-006860-a3b8hyyr	435	5	only	only	RB
cord-006860-a3b8hyyr	435	6	received	receive	VBD
cord-006860-a3b8hyyr	435	7	15000	15000	CD
cord-006860-a3b8hyyr	435	8	tU	tU	NNP
cord-006860-a3b8hyyr	435	9	standard	standard	JJ
cord-006860-a3b8hyyr	435	10	hepartn	hepartn	NNP
cord-006860-a3b8hyyr	435	11	as	as	IN
cord-006860-a3b8hyyr	435	12	i.v	i.v	NNP
cord-006860-a3b8hyyr	435	13	.	.	NNP
cord-006860-a3b8hyyr	435	14	bolus	bolus	NNP
cord-006860-a3b8hyyr	435	15	immediately	immediately	RB
cord-006860-a3b8hyyr	435	16	before	before	IN
cord-006860-a3b8hyyr	435	17	stent	stent	JJ
cord-006860-a3b8hyyr	435	18	implantation	implantation	NN
cord-006860-a3b8hyyr	435	19	(	(	-LRB-
cord-006860-a3b8hyyr	435	20	day	day	NN
cord-006860-a3b8hyyr	435	21	l	l	NN
cord-006860-a3b8hyyr	435	22	)	)	-RRB-
cord-006860-a3b8hyyr	435	23	.	.	.
cord-006860-a3b8hyyr	436	1	Side	side	JJ
cord-006860-a3b8hyyr	436	2	effects	effect	NNS
cord-006860-a3b8hyyr	436	3	and	and	CC
cord-006860-a3b8hyyr	436	4	changes	change	NNS
cord-006860-a3b8hyyr	436	5	in	in	IN
cord-006860-a3b8hyyr	436	6	hematological	hematological	JJ
cord-006860-a3b8hyyr	436	7	(	(	-LRB-
cord-006860-a3b8hyyr	436	8	day	day	NN
cord-006860-a3b8hyyr	436	9	I	-PRON-	PRP
cord-006860-a3b8hyyr	436	10	to	to	IN
cord-006860-a3b8hyyr	436	11	7	7	CD
cord-006860-a3b8hyyr	436	12	,	,	,
cord-006860-a3b8hyyr	436	13	14	14	CD
cord-006860-a3b8hyyr	436	14	.	.	.
cord-006860-a3b8hyyr	437	1	28	28	CD
cord-006860-a3b8hyyr	437	2	and	and	CC
cord-006860-a3b8hyyr	437	3	35	35	CD
cord-006860-a3b8hyyr	437	4	[	[	-LRB-
cord-006860-a3b8hyyr	437	5	=	=	NFP
cord-006860-a3b8hyyr	438	1	without	without	IN
cord-006860-a3b8hyyr	438	2	T[CIL	T[CIL	NNP
cord-006860-a3b8hyyr	438	3	liver	liver	NN
cord-006860-a3b8hyyr	438	4	and	and	CC
cord-006860-a3b8hyyr	438	5	kidney	kidney	NN
cord-006860-a3b8hyyr	438	6	parameters	parameter	NNS
cord-006860-a3b8hyyr	438	7	(	(	-LRB-
cord-006860-a3b8hyyr	438	8	day	day	NN
cord-006860-a3b8hyyr	438	9	7	7	CD
cord-006860-a3b8hyyr	438	10	,	,	,
cord-006860-a3b8hyyr	438	11	14	14	CD
cord-006860-a3b8hyyr	438	12	,	,	,
cord-006860-a3b8hyyr	438	13	28	28	CD
cord-006860-a3b8hyyr	438	14	,	,	,
cord-006860-a3b8hyyr	438	15	35	35	CD
cord-006860-a3b8hyyr	438	16	)	)	-RRB-
cord-006860-a3b8hyyr	438	17	were	be	VBD
cord-006860-a3b8hyyr	438	18	monitored	monitor	VBN
cord-006860-a3b8hyyr	438	19	.	.	.
cord-006860-a3b8hyyr	439	1	Thirty	thirty	CD
cord-006860-a3b8hyyr	439	2	-	-	HYPH
cord-006860-a3b8hyyr	439	3	eight	eight	CD
cord-006860-a3b8hyyr	439	4	PAT	PAT	NNP
cord-006860-a3b8hyyr	439	5	(	(	-LRB-
cord-006860-a3b8hyyr	439	6	75	75	CD
cord-006860-a3b8hyyr	439	7	%	%	NN
cord-006860-a3b8hyyr	439	8	)	)	-RRB-
cord-006860-a3b8hyyr	439	9	came	come	VBD
cord-006860-a3b8hyyr	439	10	for	for	IN
cord-006860-a3b8hyyr	439	11	the	the	DT
cord-006860-a3b8hyyr	439	12	controls	control	NNS
cord-006860-a3b8hyyr	439	13	to	to	IN
cord-006860-a3b8hyyr	439	14	our	-PRON-	PRP$
cord-006860-a3b8hyyr	439	15	del	del	NN
cord-006860-a3b8hyyr	439	16	~	~	CD
cord-006860-a3b8hyyr	439	17	rtment	rtment	NN
cord-006860-a3b8hyyr	439	18	and	and	CC
cord-006860-a3b8hyyr	439	19	were	be	VBD
cord-006860-a3b8hyyr	439	20	additionally	additionally	RB
cord-006860-a3b8hyyr	439	21	monitored	monitor	VBN
cord-006860-a3b8hyyr	439	22	by	by	IN
cord-006860-a3b8hyyr	439	23	thromboelastograpy	thromboelastograpy	NNP
cord-006860-a3b8hyyr	439	24	(	(	-LRB-
cord-006860-a3b8hyyr	439	25	TEG	TEG	NNP
cord-006860-a3b8hyyr	439	26	)	)	-RRB-
cord-006860-a3b8hyyr	439	27	and	and	CC
cord-006860-a3b8hyyr	439	28	bleeding	bleed	VBG
cord-006860-a3b8hyyr	439	29	time	time	NN
cord-006860-a3b8hyyr	439	30	(	(	-LRB-
cord-006860-a3b8hyyr	439	31	BT	BT	NNP
cord-006860-a3b8hyyr	439	32	)	)	-RRB-
cord-006860-a3b8hyyr	439	33	(	(	-LRB-
cord-006860-a3b8hyyr	439	34	day	day	NN
cord-006860-a3b8hyyr	439	35	2	2	CD
cord-006860-a3b8hyyr	439	36	g	g	NN
cord-006860-a3b8hyyr	439	37	and	and	CC
cord-006860-a3b8hyyr	439	38	35	35	CD
cord-006860-a3b8hyyr	439	39	)	)	-RRB-
cord-006860-a3b8hyyr	439	40	.	.	.
cord-006860-a3b8hyyr	440	1	The	the	DT
cord-006860-a3b8hyyr	440	2	other	other	JJ
cord-006860-a3b8hyyr	440	3	PAT	PAT	NNP
cord-006860-a3b8hyyr	440	4	were	be	VBD
cord-006860-a3b8hyyr	440	5	monitored	monitor	VBN
cord-006860-a3b8hyyr	440	6	externally	externally	RB
cord-006860-a3b8hyyr	440	7	,	,	,
cord-006860-a3b8hyyr	440	8	side	side	NN
cord-006860-a3b8hyyr	440	9	effects	effect	NNS
cord-006860-a3b8hyyr	440	10	were	be	VBD
cord-006860-a3b8hyyr	440	11	reported	report	VBN
cord-006860-a3b8hyyr	440	12	.	.	.
cord-006860-a3b8hyyr	441	1	Thrombin	Thrombin	NNP
cord-006860-a3b8hyyr	441	2	geucration	geucration	NN
cord-006860-a3b8hyyr	441	3	after	after	IN
cord-006860-a3b8hyyr	441	4	stenting	stenting	NN
cord-006860-a3b8hyyr	441	5	was	be	VBD
cord-006860-a3b8hyyr	441	6	monitored	monitor	VBN
cord-006860-a3b8hyyr	441	7	from	from	IN
cord-006860-a3b8hyyr	441	8	day	day	NN
cord-006860-a3b8hyyr	441	9	I	-PRON-	PRP
cord-006860-a3b8hyyr	441	10	to	to	IN
cord-006860-a3b8hyyr	441	11	7	7	CD
cord-006860-a3b8hyyr	441	12	by	by	IN
cord-006860-a3b8hyyr	441	13	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	441	14	fragment	fragment	NN
cord-006860-a3b8hyyr	441	15	1	1	CD
cord-006860-a3b8hyyr	442	1	+2	+2	NFP
cord-006860-a3b8hyyr	443	1	(	(	-LRB-
cord-006860-a3b8hyyr	443	2	F	F	NNP
cord-006860-a3b8hyyr	443	3	1	1	CD
cord-006860-a3b8hyyr	443	4	+	+	SYM
cord-006860-a3b8hyyr	443	5	2	2	CD
cord-006860-a3b8hyyr	443	6	)	)	-RRB-
cord-006860-a3b8hyyr	443	7	and	and	CC
cord-006860-a3b8hyyr	443	8	thrombin	thrombin	NN
cord-006860-a3b8hyyr	443	9	-	-	HYPH
cord-006860-a3b8hyyr	443	10	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	443	11	-	-	HYPH
cord-006860-a3b8hyyr	443	12	lll	lll	NNP
cord-006860-a3b8hyyr	443	13	-	-	HYPH
cord-006860-a3b8hyyr	443	14	comptex	comptex	NNP
cord-006860-a3b8hyyr	443	15	(	(	-LRB-
cord-006860-a3b8hyyr	443	16	TAT	tat	NN
cord-006860-a3b8hyyr	443	17	)	)	-RRB-
cord-006860-a3b8hyyr	443	18	.	.	.
cord-006860-a3b8hyyr	444	1	"	"	``
cord-006860-a3b8hyyr	444	2	K	K	NNP
cord-006860-a3b8hyyr	444	3	"	"	''
cord-006860-a3b8hyyr	444	4	of	of	IN
cord-006860-a3b8hyyr	444	5	the	the	DT
cord-006860-a3b8hyyr	444	6	"	"	``
cord-006860-a3b8hyyr	444	7	lEG	leg	CD
cord-006860-a3b8hyyr	444	8	decreased	decrease	VBD
cord-006860-a3b8hyyr	444	9	(	(	-LRB-
cord-006860-a3b8hyyr	444	10	day	day	NN
cord-006860-a3b8hyyr	444	11	28	28	CD
cord-006860-a3b8hyyr	444	12	vs	vs	IN
cord-006860-a3b8hyyr	444	13	35	35	CD
cord-006860-a3b8hyyr	444	14	;	;	:
cord-006860-a3b8hyyr	444	15	p	p	NN
cord-006860-a3b8hyyr	444	16	<	<	XX
cord-006860-a3b8hyyr	444	17	0.0l	0.0l	CD
cord-006860-a3b8hyyr	444	18	)	)	-RRB-
cord-006860-a3b8hyyr	444	19	.	.	.
cord-006860-a3b8hyyr	445	1	BT	BT	NNP
cord-006860-a3b8hyyr	445	2	prolongation	prolongation	NN
cord-006860-a3b8hyyr	445	3	was	be	VBD
cord-006860-a3b8hyyr	445	4	negatively	negatively	RB
cord-006860-a3b8hyyr	445	5	correlated	correlate	VBN
cord-006860-a3b8hyyr	445	6	with	with	IN
cord-006860-a3b8hyyr	445	7	the	the	DT
cord-006860-a3b8hyyr	445	8	bodysurf	bodysurf	NNP
cord-006860-a3b8hyyr	445	9	ace	ace	NNP
cord-006860-a3b8hyyr	445	10	area	area	NN
cord-006860-a3b8hyyr	445	11	(	(	-LRB-
cord-006860-a3b8hyyr	445	12	TIC+ASA	TIC+ASA	NNP
cord-006860-a3b8hyyr	445	13	:	:	:
cord-006860-a3b8hyyr	445	14	p	p	NN
cord-006860-a3b8hyyr	445	15	<	<	XX
cord-006860-a3b8hyyr	445	16	0.05	0.05	CD
cord-006860-a3b8hyyr	445	17	,	,	,
cord-006860-a3b8hyyr	445	18	ASA	ASA	NNP
cord-006860-a3b8hyyr	445	19	:	:	:
cord-006860-a3b8hyyr	445	20	p	p	NN
cord-006860-a3b8hyyr	445	21	<	<	XX
cord-006860-a3b8hyyr	445	22	0.0	0.0	CD
cord-006860-a3b8hyyr	445	23	l	l	NN
cord-006860-a3b8hyyr	445	24	)	)	-RRB-
cord-006860-a3b8hyyr	445	25	and	and	CC
cord-006860-a3b8hyyr	445	26	showed	show	VBD
cord-006860-a3b8hyyr	445	27	a	a	DT
cord-006860-a3b8hyyr	445	28	reduction	reduction	NN
cord-006860-a3b8hyyr	445	29	after	after	IN
cord-006860-a3b8hyyr	445	30	withdrawal	withdrawal	NN
cord-006860-a3b8hyyr	445	31	of	of	IN
cord-006860-a3b8hyyr	445	32	TIC	TIC	NNP
cord-006860-a3b8hyyr	445	33	(	(	-LRB-
cord-006860-a3b8hyyr	445	34	2	2	CD
cord-006860-a3b8hyyr	445	35	l0	l0	NNP
cord-006860-a3b8hyyr	445	36	sec	sec	NNP
cord-006860-a3b8hyyr	445	37	,	,	,
cord-006860-a3b8hyyr	445	38	180/	180/	VBD
cord-006860-a3b8hyyr	445	39	300	300	CD
cord-006860-a3b8hyyr	446	1	so	so	RB
cord-006860-a3b8hyyr	446	2	:	:	:
cord-006860-a3b8hyyr	447	1	[	[	-LRB-
cord-006860-a3b8hyyr	447	2	Median	Median	NNP
cord-006860-a3b8hyyr	447	3	,	,	,
cord-006860-a3b8hyyr	447	4	Quartiles	Quartiles	NNP
cord-006860-a3b8hyyr	447	5	]	]	-RRB-
cord-006860-a3b8hyyr	447	6	vs.	vs.	IN
cord-006860-a3b8hyyr	447	7	120	120	CD
cord-006860-a3b8hyyr	447	8	sec	sec	NNP
cord-006860-a3b8hyyr	447	9	,	,	,
cord-006860-a3b8hyyr	447	10	881157	881157	CD
cord-006860-a3b8hyyr	447	11	sec	sec	NNP
cord-006860-a3b8hyyr	447	12	;	;	:
cord-006860-a3b8hyyr	447	13	p	p	NN
cord-006860-a3b8hyyr	447	14	<	<	XX
cord-006860-a3b8hyyr	447	15	0.ix)01	0.ix)01	CD
cord-006860-a3b8hyyr	447	16	)	)	-RRB-
cord-006860-a3b8hyyr	447	17	.	.	.
cord-006860-a3b8hyyr	448	1	F	F	NNP
cord-006860-a3b8hyyr	448	2	1	1	CD
cord-006860-a3b8hyyr	448	3	+	+	SYM
cord-006860-a3b8hyyr	448	4	2	2	CD
cord-006860-a3b8hyyr	448	5	and	and	CC
cord-006860-a3b8hyyr	448	6	TAT	tat	NN
cord-006860-a3b8hyyr	448	7	of	of	IN
cord-006860-a3b8hyyr	448	8	day	day	NN
cord-006860-a3b8hyyr	448	9	I	-PRON-	PRP
cord-006860-a3b8hyyr	448	10	(	(	-LRB-
cord-006860-a3b8hyyr	448	11	blood	blood	NN
cord-006860-a3b8hyyr	448	12	collection	collection	NN
cord-006860-a3b8hyyr	448	13	:	:	:
cord-006860-a3b8hyyr	448	14	0	0	CD
cord-006860-a3b8hyyr	448	15	,	,	,
cord-006860-a3b8hyyr	448	16	2	2	CD
cord-006860-a3b8hyyr	448	17	,	,	,
cord-006860-a3b8hyyr	448	18	4	4	CD
cord-006860-a3b8hyyr	448	19	,	,	,
cord-006860-a3b8hyyr	448	20	6	6	CD
cord-006860-a3b8hyyr	448	21	h	h	NN
cord-006860-a3b8hyyr	448	22	after	after	IN
cord-006860-a3b8hyyr	448	23	intervention	intervention	NN
cord-006860-a3b8hyyr	448	24	,	,	,
cord-006860-a3b8hyyr	448	25	F	F	NNP
cord-006860-a3b8hyyr	448	26	1	1	CD
cord-006860-a3b8hyyr	448	27	+	+	SYM
cord-006860-a3b8hyyr	448	28	2:0.84	2:0.84	CD
cord-006860-a3b8hyyr	449	1	nmol	nmol	NNP
cord-006860-a3b8hyyr	449	2	/	/	SYM
cord-006860-a3b8hyyr	449	3	I	-PRON-	PRP
cord-006860-a3b8hyyr	449	4	,	,	,
cord-006860-a3b8hyyr	450	1	0.68	0.68	CD
cord-006860-a3b8hyyr	450	2	/	/	SYM
cord-006860-a3b8hyyr	450	3	I.07	i.07	CD
cord-006860-a3b8hyyr	450	4	nmol	nmol	NNP
cord-006860-a3b8hyyr	450	5	/	/	SYM
cord-006860-a3b8hyyr	450	6	l	l	NN
cord-006860-a3b8hyyr	450	7	:	:	:
cord-006860-a3b8hyyr	450	8	TAT	tat	NN
cord-006860-a3b8hyyr	450	9	:	:	:
cord-006860-a3b8hyyr	450	10	2.6	2.6	CD
cord-006860-a3b8hyyr	450	11	pg/1	pg/1	NNS
cord-006860-a3b8hyyr	450	12	,	,	,
cord-006860-a3b8hyyr	450	13	2.0/4.6	2.0/4.6	CD
cord-006860-a3b8hyyr	450	14	Ilg/1	Ilg/1	NNP
cord-006860-a3b8hyyr	450	15	)	)	-RRB-
cord-006860-a3b8hyyr	450	16	were	be	VBD
cord-006860-a3b8hyyr	450	17	lower	low	JJR
cord-006860-a3b8hyyr	450	18	compared	compare	VBN
cord-006860-a3b8hyyr	450	19	to	to	IN
cord-006860-a3b8hyyr	450	20	day	day	NN
cord-006860-a3b8hyyr	450	21	2	2	CD
cord-006860-a3b8hyyr	450	22	to	to	IN
cord-006860-a3b8hyyr	450	23	7	7	CD
cord-006860-a3b8hyyr	451	1	(	(	-LRB-
cord-006860-a3b8hyyr	451	2	F	F	NNP
cord-006860-a3b8hyyr	451	3	I	I	NNP
cord-006860-a3b8hyyr	451	4	+2	+2	NN
cord-006860-a3b8hyyr	451	5	:	:	:
cord-006860-a3b8hyyr	451	6	1.31	1.31	CD
cord-006860-a3b8hyyr	451	7	nmol	nmol	NNP
cord-006860-a3b8hyyr	451	8	/	/	SYM
cord-006860-a3b8hyyr	451	9	l	l	NN
cord-006860-a3b8hyyr	451	10	,	,	,
cord-006860-a3b8hyyr	451	11	]	]	-RRB-
cord-006860-a3b8hyyr	452	1	.08	.08	.
cord-006860-a3b8hyyr	453	1	/I	/i	NN
cord-006860-a3b8hyyr	453	2	.62	.62	CD
cord-006860-a3b8hyyr	453	3	nmol	nmol	NNP
cord-006860-a3b8hyyr	453	4	/	/	SYM
cord-006860-a3b8hyyr	453	5	l	l	NN
cord-006860-a3b8hyyr	453	6	;	;	:
cord-006860-a3b8hyyr	453	7	TAT	tat	NN
cord-006860-a3b8hyyr	453	8	:	:	:
cord-006860-a3b8hyyr	454	1	4.8	4.8	CD
cord-006860-a3b8hyyr	454	2	pg	pg	NN
cord-006860-a3b8hyyr	454	3	/	/	SYM
cord-006860-a3b8hyyr	454	4	I	I	NNP
cord-006860-a3b8hyyr	454	5	,	,	,
cord-006860-a3b8hyyr	454	6	3.2/7.2	3.2/7.2	CD
cord-006860-a3b8hyyr	454	7	IJg/1	ijg/1	NN
cord-006860-a3b8hyyr	454	8	;	;	:
cord-006860-a3b8hyyr	454	9	p	p	NN
cord-006860-a3b8hyyr	454	10	<	<	XX
cord-006860-a3b8hyyr	454	11	0.0001	0.0001	CD
cord-006860-a3b8hyyr	454	12	)	)	-RRB-
cord-006860-a3b8hyyr	454	13	.	.	.
cord-006860-a3b8hyyr	455	1	TIC	TIC	NNP
cord-006860-a3b8hyyr	455	2	scorns	scorn	VBZ
cord-006860-a3b8hyyr	455	3	not	not	RB
cord-006860-a3b8hyyr	455	4	to	to	TO
cord-006860-a3b8hyyr	455	5	be	be	VB
cord-006860-a3b8hyyr	455	6	a	a	DT
cord-006860-a3b8hyyr	455	7	strong	strong	JJ
cord-006860-a3b8hyyr	455	8	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	455	9	generation	generation	NN
cord-006860-a3b8hyyr	455	10	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	455	11	.	.	.
cord-006860-a3b8hyyr	456	1	During	during	IN
cord-006860-a3b8hyyr	456	2	stenting	stente	VBG
cord-006860-a3b8hyyr	456	3	one	one	CD
cord-006860-a3b8hyyr	456	4	PAT	PAT	NNP
cord-006860-a3b8hyyr	456	5	(	(	-LRB-
cord-006860-a3b8hyyr	456	6	I.9	i.9	NN
cord-006860-a3b8hyyr	456	7	%	%	NN
cord-006860-a3b8hyyr	456	8	)	)	-RRB-
cord-006860-a3b8hyyr	456	9	sustained	sustain	VBD
cord-006860-a3b8hyyr	456	10	a	a	DT
cord-006860-a3b8hyyr	456	11	non	non	JJ
cord-006860-a3b8hyyr	456	12	penetrating	penetrating	JJ
cord-006860-a3b8hyyr	456	13	MCI	mci	NN
cord-006860-a3b8hyyr	456	14	and	and	CC
cord-006860-a3b8hyyr	456	15	one	one	CD
cord-006860-a3b8hyyr	456	16	(	(	-LRB-
cord-006860-a3b8hyyr	456	17	1.9	1.9	CD
cord-006860-a3b8hyyr	456	18	%	%	NN
cord-006860-a3b8hyyr	456	19	)	)	-RRB-
cord-006860-a3b8hyyr	456	20	an	an	DT
cord-006860-a3b8hyyr	456	21	ischaemic	ischaemic	JJ
cord-006860-a3b8hyyr	456	22	stroke	stroke	NN
cord-006860-a3b8hyyr	456	23	.	.	.
cord-006860-a3b8hyyr	457	1	TIC+ASA	TIC+ASA	NNP
cord-006860-a3b8hyyr	457	2	were	be	VBD
cord-006860-a3b8hyyr	457	3	very	very	RB
cord-006860-a3b8hyyr	457	4	effective	effective	JJ
cord-006860-a3b8hyyr	457	5	,	,	,
cord-006860-a3b8hyyr	457	6	only	only	RB
cord-006860-a3b8hyyr	457	7	with	with	IN
cord-006860-a3b8hyyr	457	8	one	one	CD
cord-006860-a3b8hyyr	457	9	PAT	PAT	NNP
cord-006860-a3b8hyyr	457	10	(	(	-LRB-
cord-006860-a3b8hyyr	457	11	1.9	1.9	CD
cord-006860-a3b8hyyr	457	12	%	%	NN
cord-006860-a3b8hyyr	457	13	)	)	-RRB-
cord-006860-a3b8hyyr	457	14	stent	stent	NN
cord-006860-a3b8hyyr	457	15	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	457	16	(	(	-LRB-
cord-006860-a3b8hyyr	457	17	acute	acute	NNP
cord-006860-a3b8hyyr	457	18	)	)	-RRB-
cord-006860-a3b8hyyr	457	19	occurred	occur	VBD
cord-006860-a3b8hyyr	457	20	.	.	.
cord-006860-a3b8hyyr	458	1	Side	side	JJ
cord-006860-a3b8hyyr	458	2	effects	effect	NNS
cord-006860-a3b8hyyr	458	3	:	:	:
cord-006860-a3b8hyyr	458	4	8/15.7	8/15.7	CD
cord-006860-a3b8hyyr	458	5	%	%	NN
cord-006860-a3b8hyyr	458	6	gastrointestinal	gastrointestinal	JJ
cord-006860-a3b8hyyr	458	7	(	(	-LRB-
cord-006860-a3b8hyyr	458	8	one	one	CD
cord-006860-a3b8hyyr	458	9	lead	lead	NN
cord-006860-a3b8hyyr	458	10	to	to	IN
cord-006860-a3b8hyyr	458	11	hospitalization	hospitalization	NN
cord-006860-a3b8hyyr	458	12	)	)	-RRB-
cord-006860-a3b8hyyr	458	13	,	,	,
cord-006860-a3b8hyyr	458	14	5/9.8	5/9.8	CD
cord-006860-a3b8hyyr	458	15	%	%	NN
cord-006860-a3b8hyyr	458	16	hematomas	hematoma	NNS
cord-006860-a3b8hyyr	458	17	at	at	IN
cord-006860-a3b8hyyr	458	18	the	the	DT
cord-006860-a3b8hyyr	458	19	needle	needle	NN
cord-006860-a3b8hyyr	458	20	site	site	NN
cord-006860-a3b8hyyr	458	21	in	in	IN
cord-006860-a3b8hyyr	458	22	the	the	DT
cord-006860-a3b8hyyr	458	23	groin	groin	NN
cord-006860-a3b8hyyr	458	24	(	(	-LRB-
cord-006860-a3b8hyyr	458	25	one	one	CD
cord-006860-a3b8hyyr	458	26	surgical	surgical	JJ
cord-006860-a3b8hyyr	458	27	intervention	intervention	NN
cord-006860-a3b8hyyr	458	28	)	)	-RRB-
cord-006860-a3b8hyyr	458	29	,	,	,
cord-006860-a3b8hyyr	458	30	5/9.8	5/9.8	CD
cord-006860-a3b8hyyr	458	31	%	%	NN
cord-006860-a3b8hyyr	458	32	leucopcnias	leucopcnia	NNS
cord-006860-a3b8hyyr	458	33	(	(	-LRB-
cord-006860-a3b8hyyr	458	34	one	one	CD
cord-006860-a3b8hyyr	458	35	agranulozytosis	agranulozytosis	NN
cord-006860-a3b8hyyr	458	36	with	with	IN
cord-006860-a3b8hyyr	458	37	hospitalization	hospitalization	NN
cord-006860-a3b8hyyr	458	38	)	)	-RRB-
cord-006860-a3b8hyyr	458	39	,	,	,
cord-006860-a3b8hyyr	458	40	3/5.9	3/5.9	CD
cord-006860-a3b8hyyr	458	41	%	%	NN
cord-006860-a3b8hyyr	458	42	allergic	allergic	JJ
cord-006860-a3b8hyyr	458	43	skin	skin	NN
cord-006860-a3b8hyyr	458	44	reactions	reaction	NNS
cord-006860-a3b8hyyr	458	45	and	and	CC
cord-006860-a3b8hyyr	458	46	2/3.9	2/3.9	CD
cord-006860-a3b8hyyr	458	47	%	%	NN
cord-006860-a3b8hyyr	458	48	increased	increase	VBN
cord-006860-a3b8hyyr	458	49	liver	liver	NN
cord-006860-a3b8hyyr	458	50	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	458	51	(	(	-LRB-
cord-006860-a3b8hyyr	458	52	GOT	got	VBP
cord-006860-a3b8hyyr	458	53	,	,	,
cord-006860-a3b8hyyr	458	54	GPT	GPT	NNP
cord-006860-a3b8hyyr	458	55	,	,	,
cord-006860-a3b8hyyr	458	56	"	"	''
cord-006860-a3b8hyyr	458	57	pGT	pgt	JJ
cord-006860-a3b8hyyr	458	58	,	,	,
cord-006860-a3b8hyyr	458	59	alkaline	alkaline	JJ
cord-006860-a3b8hyyr	458	60	phosphatase	phosphatase	NN
cord-006860-a3b8hyyr	458	61	;	;	:
cord-006860-a3b8hyyr	458	62	>	>	XX
cord-006860-a3b8hyyr	458	63	2	2	CD
cord-006860-a3b8hyyr	458	64	×	×	NN
cord-006860-a3b8hyyr	458	65	of	of	IN
cord-006860-a3b8hyyr	458	66	the	the	DT
cord-006860-a3b8hyyr	458	67	J.	J.	NNP
cord-006860-a3b8hyyr	458	68	)	)	-RRB-
cord-006860-a3b8hyyr	458	69	.	.	.
cord-006860-a3b8hyyr	459	1	With	with	IN
cord-006860-a3b8hyyr	459	2	one	one	CD
cord-006860-a3b8hyyr	459	3	PAT	PAT	NNP
cord-006860-a3b8hyyr	459	4	with	with	IN
cord-006860-a3b8hyyr	459	5	gastrointestinal	gastrointestinal	JJ
cord-006860-a3b8hyyr	459	6	disturbances	disturbance	NNS
cord-006860-a3b8hyyr	459	7	and	and	CC
cord-006860-a3b8hyyr	459	8	skin	skin	NN
cord-006860-a3b8hyyr	459	9	reactions	reaction	NNS
cord-006860-a3b8hyyr	459	10	TIC	TIC	NNP
cord-006860-a3b8hyyr	459	11	had	have	VBD
cord-006860-a3b8hyyr	459	12	to	to	TO
cord-006860-a3b8hyyr	459	13	be	be	VB
cord-006860-a3b8hyyr	459	14	withdrawn	withdraw	VBN
cord-006860-a3b8hyyr	459	15	and	and	CC
cord-006860-a3b8hyyr	459	16	treatment	treatment	NN
cord-006860-a3b8hyyr	459	17	was	be	VBD
cord-006860-a3b8hyyr	459	18	changed	change	VBN
cord-006860-a3b8hyyr	459	19	to	to	IN
cord-006860-a3b8hyyr	459	20	oral	oral	JJ
cord-006860-a3b8hyyr	459	21	anticoagulatlon	anticoagulatlon	NNP
cord-006860-a3b8hyyr	459	22	+	+	CC
cord-006860-a3b8hyyr	459	23	ASA	ASA	NNP
cord-006860-a3b8hyyr	459	24	.	.	.
cord-006860-a3b8hyyr	460	1	One	one	CD
cord-006860-a3b8hyyr	460	2	PAT	PAT	NNP
cord-006860-a3b8hyyr	460	3	showed	show	VBD
cord-006860-a3b8hyyr	460	4	a	a	DT
cord-006860-a3b8hyyr	460	5	combination	combination	NN
cord-006860-a3b8hyyr	460	6	of	of	IN
cord-006860-a3b8hyyr	460	7	skin	skin	NN
cord-006860-a3b8hyyr	460	8	reactions	reaction	NNS
cord-006860-a3b8hyyr	460	9	,	,	,
cord-006860-a3b8hyyr	460	10	gastrointestinal	gastrointestinal	JJ
cord-006860-a3b8hyyr	460	11	distufl	distufl	NN
cord-006860-a3b8hyyr	460	12	~	~	CD
cord-006860-a3b8hyyr	460	13	aneas	aneas	NNP
cord-006860-a3b8hyyr	460	14	and	and	CC
cord-006860-a3b8hyyr	460	15	on	on	IN
cord-006860-a3b8hyyr	460	16	day	day	NN
cord-006860-a3b8hyyr	460	17	28	28	CD
cord-006860-a3b8hyyr	460	18	a	a	DT
cord-006860-a3b8hyyr	460	19	heavy	heavy	JJ
cord-006860-a3b8hyyr	460	20	reaction	reaction	NN
cord-006860-a3b8hyyr	460	21	of	of	IN
cord-006860-a3b8hyyr	460	22	the	the	DT
cord-006860-a3b8hyyr	460	23	liver	liver	NN
cord-006860-a3b8hyyr	460	24	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	460	25	(	(	-LRB-
cord-006860-a3b8hyyr	460	26	J.	J.	NNP
cord-006860-a3b8hyyr	460	27	after	after	IN
cord-006860-a3b8hyyr	460	28	5	5	CD
cord-006860-a3b8hyyr	460	29	weeks	week	NNS
cord-006860-a3b8hyyr	460	30	)	)	-RRB-
cord-006860-a3b8hyyr	460	31	.	.	.
cord-006860-a3b8hyyr	461	1	A	a	DT
cord-006860-a3b8hyyr	461	2	decrease	decrease	NN
cord-006860-a3b8hyyr	461	3	of	of	IN
cord-006860-a3b8hyyr	461	4	the	the	DT
cord-006860-a3b8hyyr	461	5	white	white	JJ
cord-006860-a3b8hyyr	461	6	blood	blood	NN
cord-006860-a3b8hyyr	461	7	count	count	NN
cord-006860-a3b8hyyr	461	8	(	(	-LRB-
cord-006860-a3b8hyyr	461	9	day	day	NN
cord-006860-a3b8hyyr	461	10	1:7.19	1:7.19	CD
cord-006860-a3b8hyyr	461	11	GH	GH	NNP
cord-006860-a3b8hyyr	461	12	,	,	,
cord-006860-a3b8hyyr	461	13	6.03/8.2	6.03/8.2	CD
cord-006860-a3b8hyyr	461	14	G	g	NN
cord-006860-a3b8hyyr	461	15	/	/	SYM
cord-006860-a3b8hyyr	461	16	l	l	NN
cord-006860-a3b8hyyr	461	17	,	,	,
cord-006860-a3b8hyyr	461	18	day	day	NN
cord-006860-a3b8hyyr	461	19	28:5.46	28:5.46	CD
cord-006860-a3b8hyyr	461	20	G	G	NNP
cord-006860-a3b8hyyr	461	21	/	/	SYM
cord-006860-a3b8hyyr	461	22	l	l	NN
cord-006860-a3b8hyyr	461	23	,	,	,
cord-006860-a3b8hyyr	461	24	4.63/6.47	4.63/6.47	CD
cord-006860-a3b8hyyr	461	25	G	G	NNP
cord-006860-a3b8hyyr	461	26	/	/	SYM
cord-006860-a3b8hyyr	461	27	l	l	NN
cord-006860-a3b8hyyr	461	28	;	;	:
cord-006860-a3b8hyyr	462	1	p	p	NN
cord-006860-a3b8hyyr	462	2	<	<	XX
cord-006860-a3b8hyyr	462	3	0.000	0.000	CD
cord-006860-a3b8hyyr	463	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	463	2	)	)	-RRB-
cord-006860-a3b8hyyr	463	3	could	could	MD
cord-006860-a3b8hyyr	463	4	be	be	VB
cord-006860-a3b8hyyr	463	5	observed	observe	VBN
cord-006860-a3b8hyyr	463	6	.	.	.
cord-006860-a3b8hyyr	464	1	The	the	DT
cord-006860-a3b8hyyr	464	2	safety	safety	NN
cord-006860-a3b8hyyr	464	3	of	of	IN
cord-006860-a3b8hyyr	464	4	the	the	DT
cord-006860-a3b8hyyr	464	5	therapy	therapy	NN
cord-006860-a3b8hyyr	464	6	with	with	IN
cord-006860-a3b8hyyr	464	7	TIC+ASA	TIC+ASA	NNP
cord-006860-a3b8hyyr	464	8	should	should	MD
cord-006860-a3b8hyyr	464	9	be	be	VB
cord-006860-a3b8hyyr	464	10	elucidated	elucidate	VBN
cord-006860-a3b8hyyr	464	11	and	and	CC
cord-006860-a3b8hyyr	464	12	extensively	extensively	RB
cord-006860-a3b8hyyr	464	13	discussed	discuss	VBN
cord-006860-a3b8hyyr	464	14	.	.	.
cord-006860-a3b8hyyr	465	1	The	the	DT
cord-006860-a3b8hyyr	465	2	serpins	serpin	NNS
cord-006860-a3b8hyyr	465	3	C1	C1	NNP
cord-006860-a3b8hyyr	465	4	esterase	esterase	NN
cord-006860-a3b8hyyr	465	5	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	465	6	(	(	-LRB-
cord-006860-a3b8hyyr	465	7	Cllnh	Cllnh	NNP
cord-006860-a3b8hyyr	465	8	)	)	-RRB-
cord-006860-a3b8hyyr	465	9	,	,	,
cord-006860-a3b8hyyr	465	10	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	465	11	III	III	NNP
cord-006860-a3b8hyyr	465	12	(	(	-LRB-
cord-006860-a3b8hyyr	465	13	ATIII	ATIII	NNP
cord-006860-a3b8hyyr	465	14	)	)	-RRB-
cord-006860-a3b8hyyr	465	15	,	,	,
cord-006860-a3b8hyyr	465	16	alantitrypsin	alantitrypsin	NNP
cord-006860-a3b8hyyr	465	17	(	(	-LRB-
cord-006860-a3b8hyyr	465	18	slAT	slAT	NNP
cord-006860-a3b8hyyr	465	19	)	)	-RRB-
cord-006860-a3b8hyyr	465	20	,	,	,
cord-006860-a3b8hyyr	465	21	and	and	CC
cord-006860-a3b8hyyr	465	22	a2-antiplasmin	a2-antiplasmin	NNP
cord-006860-a3b8hyyr	465	23	(	(	-LRB-
cord-006860-a3b8hyyr	465	24	aZAP	azap	JJ
cord-006860-a3b8hyyr	465	25	)	)	-RRB-
cord-006860-a3b8hyyr	465	26	are	be	VBP
cord-006860-a3b8hyyr	465	27	known	know	VBN
cord-006860-a3b8hyyr	465	28	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	465	29	of	of	IN
cord-006860-a3b8hyyr	465	30	coagulation	coagulation	NN
cord-006860-a3b8hyyr	465	31	factor	factor	NN
cord-006860-a3b8hyyr	465	32	Xla	Xla	NNP
cord-006860-a3b8hyyr	465	33	(	(	-LRB-
cord-006860-a3b8hyyr	465	34	FXla	FXla	NNP
cord-006860-a3b8hyyr	465	35	)	)	-RRB-
cord-006860-a3b8hyyr	465	36	.	.	.
cord-006860-a3b8hyyr	466	1	Although	although	IN
cord-006860-a3b8hyyr	466	2	initial	initial	JJ
cord-006860-a3b8hyyr	466	3	studies	study	NNS
cord-006860-a3b8hyyr	466	4	suggested	suggest	VBD
cord-006860-a3b8hyyr	466	5	al	al	NNP
cord-006860-a3b8hyyr	466	6	AT	AT	NNP
cord-006860-a3b8hyyr	466	7	to	to	TO
cord-006860-a3b8hyyr	466	8	be	be	VB
cord-006860-a3b8hyyr	466	9	the	the	DT
cord-006860-a3b8hyyr	466	10	main	main	JJ
cord-006860-a3b8hyyr	466	11	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	466	12	of	of	IN
cord-006860-a3b8hyyr	466	13	FXla	FXla	NNP
cord-006860-a3b8hyyr	466	14	,	,	,
cord-006860-a3b8hyyr	466	15	we	-PRON-	PRP
cord-006860-a3b8hyyr	466	16	recently	recently	RB
cord-006860-a3b8hyyr	466	17	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	466	18	Cllnh	Cllnh	NNP
cord-006860-a3b8hyyr	466	19	to	to	TO
cord-006860-a3b8hyyr	466	20	be	be	VB
cord-006860-a3b8hyyr	466	21	a	a	DT
cord-006860-a3b8hyyr	466	22	predominant	predominant	JJ
cord-006860-a3b8hyyr	466	23	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	466	24	of	of	IN
cord-006860-a3b8hyyr	466	25	FXla	FXla	NNP
cord-006860-a3b8hyyr	466	26	in	in	IN
cord-006860-a3b8hyyr	466	27	vitro	vitro	FW
cord-006860-a3b8hyyr	466	28	in	in	IN
cord-006860-a3b8hyyr	466	29	human	human	JJ
cord-006860-a3b8hyyr	466	30	plasma	plasma	NN
cord-006860-a3b8hyyr	467	1	(	(	-LRB-
cord-006860-a3b8hyyr	467	2	Wuillemin	Wuillemin	NNP
cord-006860-a3b8hyyr	467	3	et	et	NNP
cord-006860-a3b8hyyr	467	4	el	el	NNP
cord-006860-a3b8hyyr	467	5	.	.	NNP
cord-006860-a3b8hyyr	467	6	,	,	,
cord-006860-a3b8hyyr	467	7	Blood	blood	NN
cord-006860-a3b8hyyr	467	8	1995	1995	CD
cord-006860-a3b8hyyr	467	9	;	;	:
cord-006860-a3b8hyyr	467	10	85:1517	85:1517	CD
cord-006860-a3b8hyyr	467	11	)	)	-RRB-
cord-006860-a3b8hyyr	467	12	.	.	.
cord-006860-a3b8hyyr	468	1	The	the	DT
cord-006860-a3b8hyyr	468	2	present	present	JJ
cord-006860-a3b8hyyr	468	3	study	study	NN
cord-006860-a3b8hyyr	468	4	was	be	VBD
cord-006860-a3b8hyyr	468	5	performed	perform	VBN
cord-006860-a3b8hyyr	468	6	to	to	TO
cord-006860-a3b8hyyr	468	7	investigate	investigate	VB
cord-006860-a3b8hyyr	468	8	the	the	DT
cord-006860-a3b8hyyr	468	9	plasma	plasma	NN
cord-006860-a3b8hyyr	468	10	elimination	elimination	NN
cord-006860-a3b8hyyr	468	11	kinetics	kinetic	NNS
cord-006860-a3b8hyyr	468	12	of	of	IN
cord-006860-a3b8hyyr	468	13	human	human	JJ
cord-006860-a3b8hyyr	468	14	FXla	FXla	NNP
cord-006860-a3b8hyyr	468	15	-	-	HYPH
cord-006860-a3b8hyyr	468	16	FXla	fxla	JJ
cord-006860-a3b8hyyr	468	17	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	468	18	complexes	complex	NNS
cord-006860-a3b8hyyr	468	19	injected	inject	VBN
cord-006860-a3b8hyyr	468	20	in	in	IN
cord-006860-a3b8hyyr	468	21	rats	rat	NNS
cord-006860-a3b8hyyr	468	22	.	.	.
cord-006860-a3b8hyyr	469	1	The	the	DT
cord-006860-a3b8hyyr	469	2	amounts	amount	NNS
cord-006860-a3b8hyyr	469	3	of	of	IN
cord-006860-a3b8hyyr	469	4	complexes	complex	NNS
cord-006860-a3b8hyyr	469	5	remaining	remain	VBG
cord-006860-a3b8hyyr	469	6	in	in	IN
cord-006860-a3b8hyyr	469	7	circulation	circulation	NN
cord-006860-a3b8hyyr	469	8	were	be	VBD
cord-006860-a3b8hyyr	469	9	measured	measure	VBN
cord-006860-a3b8hyyr	469	10	using	use	VBG
cord-006860-a3b8hyyr	469	11	ELISAs	elisa	NNS
cord-006860-a3b8hyyr	469	12	.	.	.
cord-006860-a3b8hyyr	470	1	The	the	DT
cord-006860-a3b8hyyr	470	2	plasma	plasma	NN
cord-006860-a3b8hyyr	470	3	tl/2	tl/2	NN
cord-006860-a3b8hyyr	470	4	of	of	IN
cord-006860-a3b8hyyr	470	5	clearance	clearance	NN
cord-006860-a3b8hyyr	470	6	was	be	VBD
cord-006860-a3b8hyyr	470	7	98	98	CD
cord-006860-a3b8hyyr	470	8	min	min	NN
cord-006860-a3b8hyyr	470	9	for	for	IN
cord-006860-a3b8hyyr	470	10	FXla	FXla	NNP
cord-006860-a3b8hyyr	470	11	-	-	HYPH
cord-006860-a3b8hyyr	470	12	alAT	alat	NN
cord-006860-a3b8hyyr	470	13	complexes	complex	NNS
cord-006860-a3b8hyyr	470	14	,	,	,
cord-006860-a3b8hyyr	470	15	whereas	whereas	IN
cord-006860-a3b8hyyr	470	16	it	-PRON-	PRP
cord-006860-a3b8hyyr	470	17	was	be	VBD
cord-006860-a3b8hyyr	470	18	19	19	CD
cord-006860-a3b8hyyr	470	19	,	,	,
cord-006860-a3b8hyyr	470	20	1	1	CD
cord-006860-a3b8hyyr	470	21	8	8	CD
cord-006860-a3b8hyyr	470	22	,	,	,
cord-006860-a3b8hyyr	470	23	and	and	CC
cord-006860-a3b8hyyr	470	24	1	1	CD
cord-006860-a3b8hyyr	470	25	5	5	CD
cord-006860-a3b8hyyr	470	26	min	min	NN
cord-006860-a3b8hyyr	470	27	for	for	IN
cord-006860-a3b8hyyr	470	28	FXla	FXla	NNP
cord-006860-a3b8hyyr	470	29	-	-	HYPH
cord-006860-a3b8hyyr	470	30	Cllnh	Cllnh	NNP
cord-006860-a3b8hyyr	470	31	,	,	,
cord-006860-a3b8hyyr	470	32	FXla	FXla	NNP
cord-006860-a3b8hyyr	470	33	-	-	HYPH
cord-006860-a3b8hyyr	470	34	a2AP	a2ap	RB
cord-006860-a3b8hyyr	470	35	,	,	,
cord-006860-a3b8hyyr	470	36	and	and	CC
cord-006860-a3b8hyyr	470	37	FXla	FXla	NNP
cord-006860-a3b8hyyr	470	38	-	-	HYPH
cord-006860-a3b8hyyr	470	39	ATIII	ATIII	NNP
cord-006860-a3b8hyyr	470	40	complexes	complex	NNS
cord-006860-a3b8hyyr	470	41	,	,	,
cord-006860-a3b8hyyr	470	42	respectively	respectively	RB
cord-006860-a3b8hyyr	470	43	.	.	.
cord-006860-a3b8hyyr	471	1	Thus	thus	RB
cord-006860-a3b8hyyr	471	2	,	,	,
cord-006860-a3b8hyyr	471	3	due	due	IN
cord-006860-a3b8hyyr	471	4	to	to	IN
cord-006860-a3b8hyyr	471	5	this	this	DT
cord-006860-a3b8hyyr	471	6	different	different	JJ
cord-006860-a3b8hyyr	471	7	plasma	plasma	NN
cord-006860-a3b8hyyr	471	8	tl/2	tl/2	NN
cord-006860-a3b8hyyr	471	9	,	,	,
cord-006860-a3b8hyyr	471	10	preferentially	preferentially	RB
cord-006860-a3b8hyyr	471	11	FXla	FXla	NNP
cord-006860-a3b8hyyr	471	12	-	-	HYPH
cord-006860-a3b8hyyr	471	13	alAT	alat	NN
cord-006860-a3b8hyyr	471	14	complexes	complex	NNS
cord-006860-a3b8hyyr	471	15	may	may	MD
cord-006860-a3b8hyyr	471	16	be	be	VB
cord-006860-a3b8hyyr	471	17	detected	detect	VBN
cord-006860-a3b8hyyr	471	18	in	in	IN
cord-006860-a3b8hyyr	471	19	clinical	clinical	JJ
cord-006860-a3b8hyyr	471	20	samples	sample	NNS
cord-006860-a3b8hyyr	471	21	.	.	.
cord-006860-a3b8hyyr	472	1	This	this	DT
cord-006860-a3b8hyyr	472	2	was	be	VBD
cord-006860-a3b8hyyr	472	3	indeed	indeed	RB
cord-006860-a3b8hyyr	472	4	shown	show	VBN
cord-006860-a3b8hyyr	472	5	in	in	IN
cord-006860-a3b8hyyr	472	6	plasma	plasma	NN
cord-006860-a3b8hyyr	472	7	samples	sample	NNS
cord-006860-a3b8hyyr	472	8	from	from	IN
cord-006860-a3b8hyyr	472	9	thirteen	thirteen	CD
cord-006860-a3b8hyyr	472	10	children	child	NNS
cord-006860-a3b8hyyr	472	11	with	with	IN
cord-006860-a3b8hyyr	472	12	meningococcal	meningococcal	JJ
cord-006860-a3b8hyyr	472	13	septic	septic	JJ
cord-006860-a3b8hyyr	472	14	shock	shock	NN
cord-006860-a3b8hyyr	472	15	(	(	-LRB-
cord-006860-a3b8hyyr	472	16	MSS	MSS	NNP
cord-006860-a3b8hyyr	472	17	)	)	-RRB-
cord-006860-a3b8hyyr	472	18	,	,	,
cord-006860-a3b8hyyr	472	19	a	a	DT
cord-006860-a3b8hyyr	472	20	clinical	clinical	JJ
cord-006860-a3b8hyyr	472	21	syndrome	syndrome	NN
cord-006860-a3b8hyyr	472	22	which	which	WDT
cord-006860-a3b8hyyr	472	23	is	be	VBZ
cord-006860-a3b8hyyr	472	24	complicated	complicate	VBN
cord-006860-a3b8hyyr	472	25	by	by	IN
cord-006860-a3b8hyyr	472	26	activation	activation	NN
cord-006860-a3b8hyyr	472	27	of	of	IN
cord-006860-a3b8hyyr	472	28	coagulation	coagulation	NN
cord-006860-a3b8hyyr	472	29	,	,	,
cord-006860-a3b8hyyr	472	30	fibrinolytic	fibrinolytic	NN
cord-006860-a3b8hyyr	472	31	,	,	,
cord-006860-a3b8hyyr	472	32	and	and	CC
cord-006860-a3b8hyyr	472	33	complement	complement	VB
cord-006860-a3b8hyyr	472	34	systems	system	NNS
cord-006860-a3b8hyyr	472	35	.	.	.
cord-006860-a3b8hyyr	473	1	FXla	fxla	JJ
cord-006860-a3b8hyyr	473	2	-	-	HYPH
cord-006860-a3b8hyyr	473	3	FXla	fxla	JJ
cord-006860-a3b8hyyr	473	4	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	473	5	complexes	complex	NNS
cord-006860-a3b8hyyr	473	6	were	be	VBD
cord-006860-a3b8hyyr	473	7	assessed	assess	VBN
cord-006860-a3b8hyyr	473	8	upon	upon	IN
cord-006860-a3b8hyyr	473	9	admittance	admittance	NN
cord-006860-a3b8hyyr	473	10	to	to	IN
cord-006860-a3b8hyyr	473	11	the	the	DT
cord-006860-a3b8hyyr	473	12	intensive	intensive	JJ
cord-006860-a3b8hyyr	473	13	care	care	NN
cord-006860-a3b8hyyr	473	14	unit	unit	NN
cord-006860-a3b8hyyr	473	15	.	.	.
cord-006860-a3b8hyyr	474	1	FXla	FXla	NNP
cord-006860-a3b8hyyr	474	2	-	-	:
cord-006860-a3b8hyyr	474	3	a	a	DT
cord-006860-a3b8hyyr	474	4	1AT	1at	CD
cord-006860-a3b8hyyr	474	5	complexes	complex	NNS
cord-006860-a3b8hyyr	474	6	were	be	VBD
cord-006860-a3b8hyyr	474	7	elevated	elevate	VBN
cord-006860-a3b8hyyr	474	8	in	in	IN
cord-006860-a3b8hyyr	474	9	all	all	DT
cord-006860-a3b8hyyr	474	10	patients	patient	NNS
cord-006860-a3b8hyyr	474	11	,	,	,
cord-006860-a3b8hyyr	474	12	FXla	FXla	NNP
cord-006860-a3b8hyyr	474	13	-	-	HYPH
cord-006860-a3b8hyyr	474	14	C11nh	C11nh	NNP
cord-006860-a3b8hyyr	474	15	complexes	complex	NNS
cord-006860-a3b8hyyr	474	16	in	in	IN
cord-006860-a3b8hyyr	474	17	nine	nine	CD
cord-006860-a3b8hyyr	474	18	,	,	,
cord-006860-a3b8hyyr	474	19	FXla	FXla	NNP
cord-006860-a3b8hyyr	474	20	-	-	HYPH
cord-006860-a3b8hyyr	474	21	ATIII	ATIII	NNP
cord-006860-a3b8hyyr	474	22	complexes	complex	NNS
cord-006860-a3b8hyyr	474	23	in	in	IN
cord-006860-a3b8hyyr	474	24	one	one	CD
cord-006860-a3b8hyyr	474	25	patient	patient	NN
cord-006860-a3b8hyyr	474	26	,	,	,
cord-006860-a3b8hyyr	474	27	and	and	CC
cord-006860-a3b8hyyr	474	28	no	no	DT
cord-006860-a3b8hyyr	474	29	elevated	elevated	JJ
cord-006860-a3b8hyyr	474	30	FXla	FXla	NNP
cord-006860-a3b8hyyr	474	31	-	-	HYPH
cord-006860-a3b8hyyr	474	32	a2AP	a2ap	NN
cord-006860-a3b8hyyr	474	33	complexes	complex	NNS
cord-006860-a3b8hyyr	474	34	were	be	VBD
cord-006860-a3b8hyyr	474	35	found	find	VBN
cord-006860-a3b8hyyr	474	36	.	.	.
cord-006860-a3b8hyyr	475	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	475	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	475	3	from	from	IN
cord-006860-a3b8hyyr	475	4	this	this	DT
cord-006860-a3b8hyyr	475	5	study	study	NN
cord-006860-a3b8hyyr	475	6	that	that	IN
cord-006860-a3b8hyyr	475	7	,	,	,
cord-006860-a3b8hyyr	475	8	(	(	-LRB-
cord-006860-a3b8hyyr	475	9	1	1	CD
cord-006860-a3b8hyyr	475	10	)	)	-RRB-
cord-006860-a3b8hyyr	475	11	although	although	IN
cord-006860-a3b8hyyr	475	12	C1	C1	NNP
cord-006860-a3b8hyyr	475	13	Inh	Inh	NNP
cord-006860-a3b8hyyr	475	14	is	be	VBZ
cord-006860-a3b8hyyr	475	15	the	the	DT
cord-006860-a3b8hyyr	475	16	predominant	predominant	JJ
cord-006860-a3b8hyyr	475	17	FXla	fxla	JJ
cord-006860-a3b8hyyr	475	18	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	475	19	,	,	,
cord-006860-a3b8hyyr	475	20	FXla	FXla	NNP
cord-006860-a3b8hyyr	475	21	-	-	HYPH
cord-006860-a3b8hyyr	475	22	alAT	alat	NN
cord-006860-a3b8hyyr	475	23	complexes	complex	NNS
cord-006860-a3b8hyyr	475	24	may	may	MD
cord-006860-a3b8hyyr	475	25	be	be	VB
cord-006860-a3b8hyyr	475	26	the	the	DT
cord-006860-a3b8hyyr	475	27	best	good	JJS
cord-006860-a3b8hyyr	475	28	parameter	parameter	NN
cord-006860-a3b8hyyr	475	29	to	to	TO
cord-006860-a3b8hyyr	475	30	assess	assess	VB
cord-006860-a3b8hyyr	475	31	activation	activation	NN
cord-006860-a3b8hyyr	475	32	of	of	IN
cord-006860-a3b8hyyr	475	33	FXI	FXI	NNP
cord-006860-a3b8hyyr	475	34	in	in	IN
cord-006860-a3b8hyyr	475	35	clinical	clinical	JJ
cord-006860-a3b8hyyr	475	36	samples	sample	NNS
cord-006860-a3b8hyyr	475	37	,	,	,
cord-006860-a3b8hyyr	475	38	(	(	-LRB-
cord-006860-a3b8hyyr	475	39	2	2	LS
cord-006860-a3b8hyyr	475	40	)	)	-RRB-
cord-006860-a3b8hyyr	475	41	measuring	measure	VBG
cord-006860-a3b8hyyr	476	1	FXla	fxla	JJ
cord-006860-a3b8hyyr	476	2	-	-	HYPH
cord-006860-a3b8hyyr	476	3	FXla	fxla	JJ
cord-006860-a3b8hyyr	476	4	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	476	5	complexes	complex	NNS
cord-006860-a3b8hyyr	476	6	in	in	IN
cord-006860-a3b8hyyr	476	7	patient	patient	NN
cord-006860-a3b8hyyr	476	8	samples	sample	NNS
cord-006860-a3b8hyyr	476	9	may	may	MD
cord-006860-a3b8hyyr	476	10	not	not	RB
cord-006860-a3b8hyyr	476	11	help	help	VB
cord-006860-a3b8hyyr	476	12	to	to	TO
cord-006860-a3b8hyyr	476	13	clarify	clarify	VB
cord-006860-a3b8hyyr	476	14	the	the	DT
cord-006860-a3b8hyyr	476	15	relative	relative	JJ
cord-006860-a3b8hyyr	476	16	contribution	contribution	NN
cord-006860-a3b8hyyr	476	17	of	of	IN
cord-006860-a3b8hyyr	476	18	the	the	DT
cord-006860-a3b8hyyr	476	19	individual	individual	JJ
cord-006860-a3b8hyyr	476	20	serpins	serpin	NNS
cord-006860-a3b8hyyr	476	21	to	to	IN
cord-006860-a3b8hyyr	476	22	inactivation	inactivation	NN
cord-006860-a3b8hyyr	476	23	of	of	IN
cord-006860-a3b8hyyr	476	24	FXla	FXla	NNP
cord-006860-a3b8hyyr	476	25	in	in	IN
cord-006860-a3b8hyyr	476	26	rive	rive	NNP
cord-006860-a3b8hyyr	476	27	,	,	,
cord-006860-a3b8hyyr	476	28	and	and	CC
cord-006860-a3b8hyyr	476	29	(	(	-LRB-
cord-006860-a3b8hyyr	476	30	3	3	LS
cord-006860-a3b8hyyr	476	31	)	)	-RRB-
cord-006860-a3b8hyyr	476	32	FXl	FXl	NNS
cord-006860-a3b8hyyr	476	33	is	be	VBZ
cord-006860-a3b8hyyr	476	34	activated	activate	VBN
cord-006860-a3b8hyyr	476	35	in	in	IN
cord-006860-a3b8hyyr	476	36	patients	patient	NNS
cord-006860-a3b8hyyr	476	37	with	with	IN
cord-006860-a3b8hyyr	476	38	meningococcal	meningococcal	JJ
cord-006860-a3b8hyyr	476	39	septic	septic	JJ
cord-006860-a3b8hyyr	476	40	shock	shock	NN
cord-006860-a3b8hyyr	476	41	.	.	.
cord-006860-a3b8hyyr	477	1	Dudng	Dudng	NNP
cord-006860-a3b8hyyr	477	2	the	the	DT
cord-006860-a3b8hyyr	477	3	coagulation	coagulation	NN
cord-006860-a3b8hyyr	477	4	of	of	IN
cord-006860-a3b8hyyr	477	5	plasma	plasma	NN
cord-006860-a3b8hyyr	477	6	about	about	RB
cord-006860-a3b8hyyr	477	7	20	20	CD
cord-006860-a3b8hyyr	477	8	%	%	NN
cord-006860-a3b8hyyr	477	9	of	of	IN
cord-006860-a3b8hyyr	477	10	the	the	DT
cord-006860-a3b8hyyr	477	11	(	(	-LRB-
cord-006860-a3b8hyyr	477	12	x2AP	x2AP	NNP
cord-006860-a3b8hyyr	477	13	present	present	JJ
cord-006860-a3b8hyyr	477	14	is	be	VBZ
cord-006860-a3b8hyyr	477	15	covalently	covalently	RB
cord-006860-a3b8hyyr	477	16	crosslinked	crosslinke	VBN
cord-006860-a3b8hyyr	477	17	to	to	IN
cord-006860-a3b8hyyr	477	18	fibrin	fibrin	NN
cord-006860-a3b8hyyr	477	19	by	by	IN
cord-006860-a3b8hyyr	477	20	factor	factor	NN
cord-006860-a3b8hyyr	478	1	XIIla	xiila	NN
cord-006860-a3b8hyyr	479	1	(	(	-LRB-
cord-006860-a3b8hyyr	479	2	Aoki	Aoki	NNP
cord-006860-a3b8hyyr	479	3	und	und	IN
cord-006860-a3b8hyyr	479	4	Sakata	Sakata	NNP
cord-006860-a3b8hyyr	479	5	1980	1980	CD
cord-006860-a3b8hyyr	479	6	,	,	,
cord-006860-a3b8hyyr	479	7	Thomb	Thomb	NNP
cord-006860-a3b8hyyr	479	8	.	.	.
cord-006860-a3b8hyyr	480	1	Res	Res	NNP
cord-006860-a3b8hyyr	480	2	.	.	.
cord-006860-a3b8hyyr	481	1	19	19	CD
cord-006860-a3b8hyyr	481	2	:	:	SYM
cord-006860-a3b8hyyr	481	3	149	149	CD
cord-006860-a3b8hyyr	481	4	-	-	SYM
cord-006860-a3b8hyyr	481	5	155	155	CD
cord-006860-a3b8hyyr	481	6	)	)	-RRB-
cord-006860-a3b8hyyr	481	7	.	.	.
cord-006860-a3b8hyyr	482	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	482	2	investigated	investigate	VBD
cord-006860-a3b8hyyr	482	3	the	the	DT
cord-006860-a3b8hyyr	482	4	binding	binding	NN
cord-006860-a3b8hyyr	482	5	of	of	IN
cord-006860-a3b8hyyr	482	6	azAP	azap	NN
cord-006860-a3b8hyyr	482	7	by	by	IN
cord-006860-a3b8hyyr	482	8	factor	factor	NN
cord-006860-a3b8hyyr	482	9	XIIla	xiila	NN
cord-006860-a3b8hyyr	482	10	to	to	IN
cord-006860-a3b8hyyr	482	11	soluble	soluble	JJ
cord-006860-a3b8hyyr	482	12	fibrin	fibrin	NN
cord-006860-a3b8hyyr	482	13	(	(	-LRB-
cord-006860-a3b8hyyr	482	14	desAABB	desAABB	NNP
cord-006860-a3b8hyyr	482	15	-	-	HYPH
cord-006860-a3b8hyyr	482	16	fibdno	fibdno	NN
cord-006860-a3b8hyyr	482	17	)	)	-RRB-
cord-006860-a3b8hyyr	482	18	whose	whose	WP$
cord-006860-a3b8hyyr	482	19	polymerization	polymerization	NN
cord-006860-a3b8hyyr	482	20	was	be	VBD
cord-006860-a3b8hyyr	482	21	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	482	22	by	by	IN
cord-006860-a3b8hyyr	482	23	an	an	DT
cord-006860-a3b8hyyr	482	24	isolated	isolated	JJ
cord-006860-a3b8hyyr	482	25	fibrin	fibrin	NN
cord-006860-a3b8hyyr	482	26	Ddomain	Ddomain	NNP
cord-006860-a3b8hyyr	482	27	named	name	VBN
cord-006860-a3b8hyyr	482	28	D=	D=	NNP
cord-006860-a3b8hyyr	482	29	,	,	,
cord-006860-a3b8hyyr	482	30	,	,	,
cord-006860-a3b8hyyr	482	31	,	,	,
cord-006860-a3b8hyyr	482	32	(	(	-LRB-
cord-006860-a3b8hyyr	482	33	Haverkate	Haverkate	NNP
cord-006860-a3b8hyyr	482	34	and	and	CC
cord-006860-a3b8hyyr	482	35	Tiemann	Tiemann	NNP
cord-006860-a3b8hyyr	482	36	1977	1977	CD
cord-006860-a3b8hyyr	482	37	,	,	,
cord-006860-a3b8hyyr	482	38	Thromb	Thromb	NNP
cord-006860-a3b8hyyr	482	39	.	.	.
cord-006860-a3b8hyyr	483	1	Res	Res	NNP
cord-006860-a3b8hyyr	483	2	.	.	.
cord-006860-a3b8hyyr	484	1	10	10	CD
cord-006860-a3b8hyyr	484	2	:	:	SYM
cord-006860-a3b8hyyr	484	3	803	803	CD
cord-006860-a3b8hyyr	484	4	-	-	SYM
cord-006860-a3b8hyyr	484	5	812	812	CD
cord-006860-a3b8hyyr	484	6	)	)	-RRB-
cord-006860-a3b8hyyr	484	7	.	.	.
cord-006860-a3b8hyyr	485	1	D==.	D==.	NNS
cord-006860-a3b8hyyr	485	2	is	be	VBZ
cord-006860-a3b8hyyr	485	3	known	know	VBN
cord-006860-a3b8hyyr	485	4	to	to	TO
cord-006860-a3b8hyyr	485	5	have	have	VB
cord-006860-a3b8hyyr	485	6	an	an	DT
cord-006860-a3b8hyyr	485	7	intact	intact	JJ
cord-006860-a3b8hyyr	485	8	fibrin	fibrin	NN
cord-006860-a3b8hyyr	485	9	-	-	HYPH
cord-006860-a3b8hyyr	485	10	polymerization	polymerization	NN
cord-006860-a3b8hyyr	485	11	site	site	NN
cord-006860-a3b8hyyr	485	12	and	and	CC
cord-006860-a3b8hyyr	485	13	is	be	VBZ
cord-006860-a3b8hyyr	485	14	able	able	JJ
cord-006860-a3b8hyyr	485	15	to	to	TO
cord-006860-a3b8hyyr	485	16	block	block	VB
cord-006860-a3b8hyyr	485	17	the	the	DT
cord-006860-a3b8hyyr	485	18	prolongation	prolongation	NN
cord-006860-a3b8hyyr	485	19	of	of	IN
cord-006860-a3b8hyyr	485	20	the	the	DT
cord-006860-a3b8hyyr	485	21	fibrin	fibrin	NN
cord-006860-a3b8hyyr	485	22	protofibrils	protofibril	NNS
cord-006860-a3b8hyyr	485	23	at	at	IN
cord-006860-a3b8hyyr	485	24	an	an	DT
cord-006860-a3b8hyyr	485	25	early	early	JJ
cord-006860-a3b8hyyr	485	26	stage	stage	NN
cord-006860-a3b8hyyr	485	27	depending	depend	VBG
cord-006860-a3b8hyyr	485	28	on	on	IN
cord-006860-a3b8hyyr	485	29	its	-PRON-	PRP$
cord-006860-a3b8hyyr	485	30	concentration	concentration	NN
cord-006860-a3b8hyyr	485	31	.	.	.
cord-006860-a3b8hyyr	486	1	Lateral	lateral	JJ
cord-006860-a3b8hyyr	486	2	association	association	NN
cord-006860-a3b8hyyr	486	3	to	to	IN
cord-006860-a3b8hyyr	486	4	fibrin	fibrin	NN
cord-006860-a3b8hyyr	486	5	fibers	fiber	NNS
cord-006860-a3b8hyyr	486	6	does	do	VBZ
cord-006860-a3b8hyyr	486	7	not	not	RB
cord-006860-a3b8hyyr	486	8	take	take	VB
cord-006860-a3b8hyyr	486	9	place	place	NN
cord-006860-a3b8hyyr	486	10	,	,	,
cord-006860-a3b8hyyr	486	11	since	since	IN
cord-006860-a3b8hyyr	486	12	the	the	DT
cord-006860-a3b8hyyr	486	13	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	486	14	protofibnls	protofibnls	NN
cord-006860-a3b8hyyr	486	15	formed	form	VBN
cord-006860-a3b8hyyr	486	16	at	at	IN
cord-006860-a3b8hyyr	486	17	the	the	DT
cord-006860-a3b8hyyr	486	18	conditions	condition	NNS
cord-006860-a3b8hyyr	486	19	used	use	VBN
cord-006860-a3b8hyyr	486	20	here	here	RB
cord-006860-a3b8hyyr	486	21	do	do	VBP
cord-006860-a3b8hyyr	486	22	not	not	RB
cord-006860-a3b8hyyr	486	23	reach	reach	VB
cord-006860-a3b8hyyr	486	24	a	a	DT
cord-006860-a3b8hyyr	486	25	sufficient	sufficient	JJ
cord-006860-a3b8hyyr	486	26	length	length	NN
cord-006860-a3b8hyyr	486	27	(	(	-LRB-
cord-006860-a3b8hyyr	486	28	Williams	Williams	NNP
cord-006860-a3b8hyyr	486	29	et	et	NNP
cord-006860-a3b8hyyr	486	30	el	el	NNP
cord-006860-a3b8hyyr	486	31	.	.	.
cord-006860-a3b8hyyr	487	1	1981	1981	CD
cord-006860-a3b8hyyr	487	2	,	,	,
cord-006860-a3b8hyyr	487	3	Biochem	Biochem	NNP
cord-006860-a3b8hyyr	487	4	.	.	.
cord-006860-a3b8hyyr	488	1	J.	J.	NNP
cord-006860-a3b8hyyr	488	2	197	197	CD
cord-006860-a3b8hyyr	488	3	:	:	:
cord-006860-a3b8hyyr	489	1	661	661	CD
cord-006860-a3b8hyyr	489	2	-	-	SYM
cord-006860-a3b8hyyr	489	3	668	668	CD
cord-006860-a3b8hyyr	490	1	;	;	:
cord-006860-a3b8hyyr	490	2	Hantgan	Hantgan	NNP
cord-006860-a3b8hyyr	490	3	et	et	FW
cord-006860-a3b8hyyr	490	4	al	al	NNP
cord-006860-a3b8hyyr	490	5	.	.	.
cord-006860-a3b8hyyr	491	1	1983	1983	CD
cord-006860-a3b8hyyr	491	2	,	,	,
cord-006860-a3b8hyyr	491	3	Ann	Ann	NNP
cord-006860-a3b8hyyr	491	4	.	.	.
cord-006860-a3b8hyyr	492	1	N.	N.	NNP
cord-006860-a3b8hyyr	492	2	Y.	Y.	NNP
cord-006860-a3b8hyyr	492	3	Acad	Acad	NNP
cord-006860-a3b8hyyr	492	4	Sci	Sci	NNP
cord-006860-a3b8hyyr	492	5	.	.	.
cord-006860-a3b8hyyr	493	1	408	408	CD
cord-006860-a3b8hyyr	493	2	:	:	:
cord-006860-a3b8hyyr	493	3	344	344	CD
cord-006860-a3b8hyyr	493	4	-	-	SYM
cord-006860-a3b8hyyr	493	5	365	365	CD
cord-006860-a3b8hyyr	493	6	)	)	-RRB-
cord-006860-a3b8hyyr	493	7	.	.	.
cord-006860-a3b8hyyr	494	1	Material	material	NN
cord-006860-a3b8hyyr	494	2	and	and	CC
cord-006860-a3b8hyyr	494	3	method	method	NN
cord-006860-a3b8hyyr	494	4	:	:	:
cord-006860-a3b8hyyr	494	5	Soluble	Soluble	NNP
cord-006860-a3b8hyyr	494	6	desAABB	desAABB	NNS
cord-006860-a3b8hyyr	494	7	-	-	HYPH
cord-006860-a3b8hyyr	494	8	fibrino	fibrino	NNP
cord-006860-a3b8hyyr	494	9	was	be	VBD
cord-006860-a3b8hyyr	494	10	prepared	prepare	VBN
cord-006860-a3b8hyyr	494	11	by	by	IN
cord-006860-a3b8hyyr	494	12	incubation	incubation	NN
cord-006860-a3b8hyyr	494	13	of	of	IN
cord-006860-a3b8hyyr	494	14	(	(	-LRB-
cord-006860-a3b8hyyr	494	15	lZtl)-fibrinogen	lztl)-fibrinogen	NN
cord-006860-a3b8hyyr	494	16	(	(	-LRB-
cord-006860-a3b8hyyr	494	17	0.48	0.48	CD
cord-006860-a3b8hyyr	494	18	mg	mg	NNP
cord-006860-a3b8hyyr	494	19	/	/	SYM
cord-006860-a3b8hyyr	494	20	ml	ml	NNP
cord-006860-a3b8hyyr	494	21	)	)	-RRB-
cord-006860-a3b8hyyr	494	22	,	,	,
cord-006860-a3b8hyyr	494	23	D=1o	d=1o	XX
cord-006860-a3b8hyyr	495	1	(	(	-LRB-
cord-006860-a3b8hyyr	495	2	1.91	1.91	CD
cord-006860-a3b8hyyr	495	3	mg	mg	NNP
cord-006860-a3b8hyyr	495	4	/	/	SYM
cord-006860-a3b8hyyr	495	5	ml	ml	NN
cord-006860-a3b8hyyr	495	6	;	;	:
cord-006860-a3b8hyyr	495	7	molar	molar	JJ
cord-006860-a3b8hyyr	495	8	ratio	ratio	NN
cord-006860-a3b8hyyr	495	9	D==o	D==o	NNS
cord-006860-a3b8hyyr	495	10	to	to	TO
cord-006860-a3b8hyyr	495	11	fibrin	fibrin	NN
cord-006860-a3b8hyyr	495	12	14:1	14:1	CD
cord-006860-a3b8hyyr	495	13	)	)	-RRB-
cord-006860-a3b8hyyr	495	14	and	and	CC
cord-006860-a3b8hyyr	495	15	0.4	0.4	CD
cord-006860-a3b8hyyr	495	16	U	u	NN
cord-006860-a3b8hyyr	495	17	/	/	SYM
cord-006860-a3b8hyyr	495	18	ml	ml	XX
cord-006860-a3b8hyyr	495	19	thmmbin	thmmbin	NNP
cord-006860-a3b8hyyr	495	20	for	for	IN
cord-006860-a3b8hyyr	495	21	45	45	CD
cord-006860-a3b8hyyr	495	22	min	min	NN
cord-006860-a3b8hyyr	495	23	.	.	.
cord-006860-a3b8hyyr	496	1	Then	then	RB
cord-006860-a3b8hyyr	496	2	Q2sl)-c~2AP	q2sl)-c~2ap	NN
cord-006860-a3b8hyyr	496	3	(	(	-LRB-
cord-006860-a3b8hyyr	496	4	16	16	CD
cord-006860-a3b8hyyr	496	5	p.g	p.g	NNP
cord-006860-a3b8hyyr	496	6	/	/	SYM
cord-006860-a3b8hyyr	496	7	ml	ml	NNP
cord-006860-a3b8hyyr	496	8	)	)	-RRB-
cord-006860-a3b8hyyr	496	9	,	,	,
cord-006860-a3b8hyyr	496	10	faktor	faktor	NNP
cord-006860-a3b8hyyr	496	11	×Ill	×Ill	NNP
cord-006860-a3b8hyyr	496	12	(	(	-LRB-
cord-006860-a3b8hyyr	496	13	2	2	CD
cord-006860-a3b8hyyr	496	14	Ulml	Ulml	NNP
cord-006860-a3b8hyyr	496	15	)	)	-RRB-
cord-006860-a3b8hyyr	496	16	and	and	CC
cord-006860-a3b8hyyr	496	17	Ca	Ca	NNP
cord-006860-a3b8hyyr	496	18	2	2	CD
cord-006860-a3b8hyyr	496	19	)	)	-RRB-
cord-006860-a3b8hyyr	497	1	(	(	-LRB-
cord-006860-a3b8hyyr	497	2	5	5	CD
cord-006860-a3b8hyyr	497	3	mmol	mmol	JJ
cord-006860-a3b8hyyr	497	4	/	/	SYM
cord-006860-a3b8hyyr	497	5	I	i	NN
cord-006860-a3b8hyyr	497	6	)	)	-RRB-
cord-006860-a3b8hyyr	497	7	were	be	VBD
cord-006860-a3b8hyyr	497	8	added	add	VBN
cord-006860-a3b8hyyr	497	9	.	.	.
cord-006860-a3b8hyyr	498	1	The	the	DT
cord-006860-a3b8hyyr	498	2	crosslinking	crosslinking	NN
cord-006860-a3b8hyyr	498	3	reaction	reaction	NN
cord-006860-a3b8hyyr	498	4	was	be	VBD
cord-006860-a3b8hyyr	498	5	stopped	stop	VBN
cord-006860-a3b8hyyr	498	6	at	at	IN
cord-006860-a3b8hyyr	498	7	different	different	JJ
cord-006860-a3b8hyyr	498	8	times	time	NNS
cord-006860-a3b8hyyr	498	9	of	of	IN
cord-006860-a3b8hyyr	498	10	factor	factor	NN
cord-006860-a3b8hyyr	498	11	XIIla	xiila	NN
cord-006860-a3b8hyyr	498	12	-	-	HYPH
cord-006860-a3b8hyyr	498	13	incubation	incubation	NN
cord-006860-a3b8hyyr	498	14	by	by	IN
cord-006860-a3b8hyyr	498	15	adding	add	VBG
cord-006860-a3b8hyyr	498	16	of	of	IN
cord-006860-a3b8hyyr	498	17	urea	urea	NN
cord-006860-a3b8hyyr	498	18	/	/	SYM
cord-006860-a3b8hyyr	498	19	EDTAsolution	edtasolution	NN
cord-006860-a3b8hyyr	498	20	.	.	.
cord-006860-a3b8hyyr	499	1	The	the	DT
cord-006860-a3b8hyyr	499	2	suspension	suspension	NN
cord-006860-a3b8hyyr	499	3	was	be	VBD
cord-006860-a3b8hyyr	499	4	analysed	analyse	VBN
cord-006860-a3b8hyyr	499	5	by	by	IN
cord-006860-a3b8hyyr	499	6	ultracentrifugation	ultracentrifugation	NN
cord-006860-a3b8hyyr	499	7	on	on	IN
cord-006860-a3b8hyyr	499	8	gradients	gradient	NNS
cord-006860-a3b8hyyr	499	9	containing	contain	VBG
cord-006860-a3b8hyyr	499	10	saccharose	saccharose	NNS
cord-006860-a3b8hyyr	499	11	,	,	,
cord-006860-a3b8hyyr	499	12	urea	urea	NN
cord-006860-a3b8hyyr	499	13	and	and	CC
cord-006860-a3b8hyyr	499	14	SOS	SOS	NNP
cord-006860-a3b8hyyr	499	15	.	.	.
cord-006860-a3b8hyyr	500	1	Re	re	IN
cord-006860-a3b8hyyr	500	2	~	~	CD
cord-006860-a3b8hyyr	500	3	ultl	ultl	NN
cord-006860-a3b8hyyr	500	4	:	:	:
cord-006860-a3b8hyyr	500	5	The	the	DT
cord-006860-a3b8hyyr	500	6	elution	elution	NN
cord-006860-a3b8hyyr	500	7	profiles	profile	NNS
cord-006860-a3b8hyyr	500	8	of	of	IN
cord-006860-a3b8hyyr	500	9	the	the	DT
cord-006860-a3b8hyyr	500	10	ultrecentifugation	ultrecentifugation	NN
cord-006860-a3b8hyyr	500	11	-	-	HYPH
cord-006860-a3b8hyyr	500	12	gradients	gradient	NNS
cord-006860-a3b8hyyr	500	13	show	show	VBP
cord-006860-a3b8hyyr	500	14	the	the	DT
cord-006860-a3b8hyyr	500	15	formation	formation	NN
cord-006860-a3b8hyyr	500	16	of	of	IN
cord-006860-a3b8hyyr	500	17	cmsslinked	cmsslinked	JJ
cord-006860-a3b8hyyr	500	18	fibrin	fibrin	NN
cord-006860-a3b8hyyr	500	19	oligomers	oligomer	NNS
cord-006860-a3b8hyyr	500	20	of	of	IN
cord-006860-a3b8hyyr	500	21	increasing	increase	VBG
cord-006860-a3b8hyyr	500	22	size	size	NN
cord-006860-a3b8hyyr	500	23	depending	depend	VBG
cord-006860-a3b8hyyr	500	24	on	on	IN
cord-006860-a3b8hyyr	500	25	the	the	DT
cord-006860-a3b8hyyr	500	26	time	time	NN
cord-006860-a3b8hyyr	500	27	of	of	IN
cord-006860-a3b8hyyr	500	28	Factor	Factor	NNP
cord-006860-a3b8hyyr	500	29	XIIla	XIIla	NNP
cord-006860-a3b8hyyr	500	30	-	-	HYPH
cord-006860-a3b8hyyr	500	31	action	action	NN
cord-006860-a3b8hyyr	500	32	.	.	.
cord-006860-a3b8hyyr	501	1	The	the	DT
cord-006860-a3b8hyyr	501	2	crosslinked	crosslinked	JJ
cord-006860-a3b8hyyr	501	3	fibrin	fibrin	NN
cord-006860-a3b8hyyr	501	4	polymers	polymer	NNS
cord-006860-a3b8hyyr	501	5	contained	contain	VBN
cord-006860-a3b8hyyr	501	6	about	about	RB
cord-006860-a3b8hyyr	501	7	80	80	CD
cord-006860-a3b8hyyr	501	8	%	%	NN
cord-006860-a3b8hyyr	501	9	of	of	IN
cord-006860-a3b8hyyr	501	10	the	the	DT
cord-006860-a3b8hyyr	501	11	fibrin	fibrin	NN
cord-006860-a3b8hyyr	501	12	initially	initially	RB
cord-006860-a3b8hyyr	501	13	added	add	VBD
cord-006860-a3b8hyyr	501	14	.	.	.
cord-006860-a3b8hyyr	502	1	Although	although	IN
cord-006860-a3b8hyyr	502	2	Factor	Factor	NNP
cord-006860-a3b8hyyr	502	3	XIIla	XIIla	NNP
cord-006860-a3b8hyyr	502	4	acted	act	VBD
cord-006860-a3b8hyyr	502	5	well	well	RB
cord-006860-a3b8hyyr	502	6	,	,	,
cord-006860-a3b8hyyr	502	7	crosslinking	crosslinking	NN
cord-006860-a3b8hyyr	502	8	of	of	IN
cord-006860-a3b8hyyr	502	9	azAP	azap	NN
cord-006860-a3b8hyyr	502	10	In	in	IN
cord-006860-a3b8hyyr	502	11	the	the	DT
cord-006860-a3b8hyyr	502	12	fibrin	fibrin	NN
cord-006860-a3b8hyyr	502	13	oligomers	oligomer	NNS
cord-006860-a3b8hyyr	502	14	could	could	MD
cord-006860-a3b8hyyr	502	15	not	not	RB
cord-006860-a3b8hyyr	502	16	be	be	VB
cord-006860-a3b8hyyr	502	17	observed	observe	VBN
cord-006860-a3b8hyyr	502	18	.	.	.
cord-006860-a3b8hyyr	503	1	Conclusl0n	conclusl0n	NN
cord-006860-a3b8hyyr	503	2	:	:	:
cord-006860-a3b8hyyr	504	1	As	as	IN
cord-006860-a3b8hyyr	504	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	504	3	already	already	RB
cord-006860-a3b8hyyr	504	4	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	504	5	(	(	-LRB-
cord-006860-a3b8hyyr	504	6	Kelach	Kelach	NNP
cord-006860-a3b8hyyr	504	7	et	et	FW
cord-006860-a3b8hyyr	504	8	el	el	NNP
cord-006860-a3b8hyyr	504	9	.	.	NNP
cord-006860-a3b8hyyr	504	10	1994	1994	CD
cord-006860-a3b8hyyr	504	11	,	,	,
cord-006860-a3b8hyyr	504	12	Ann	Ann	NNP
cord-006860-a3b8hyyr	504	13	,	,	,
cord-006860-a3b8hyyr	504	14	Hematol	Hematol	NNP
cord-006860-a3b8hyyr	504	15	.	.	.
cord-006860-a3b8hyyr	504	16	70	70	CD
cord-006860-a3b8hyyr	504	17	(	(	-LRB-
cord-006860-a3b8hyyr	504	18	suppll	suppll	NN
cord-006860-a3b8hyyr	504	19	)	)	-RRB-
cord-006860-a3b8hyyr	504	20	:	:	:
cord-006860-a3b8hyyr	505	1	A	a	DT
cord-006860-a3b8hyyr	505	2	60	60	CD
cord-006860-a3b8hyyr	505	3	)	)	-RRB-
cord-006860-a3b8hyyr	505	4	the	the	DT
cord-006860-a3b8hyyr	505	5	crosslinking	crosslinking	NN
cord-006860-a3b8hyyr	505	6	of	of	IN
cord-006860-a3b8hyyr	505	7	azAP	azap	NN
cord-006860-a3b8hyyr	505	8	to	to	TO
cord-006860-a3b8hyyr	505	9	fibnn	fibnn	VB
cord-006860-a3b8hyyr	505	10	clots	clot	NNS
cord-006860-a3b8hyyr	505	11	depends	depend	VBZ
cord-006860-a3b8hyyr	505	12	on	on	IN
cord-006860-a3b8hyyr	505	13	the	the	DT
cord-006860-a3b8hyyr	505	14	structure	structure	NN
cord-006860-a3b8hyyr	505	15	of	of	IN
cord-006860-a3b8hyyr	505	16	the	the	DT
cord-006860-a3b8hyyr	505	17	fibdn	fibdn	NNP
cord-006860-a3b8hyyr	505	18	network	network	NNP
cord-006860-a3b8hyyr	505	19	,	,	,
cord-006860-a3b8hyyr	505	20	especially	especially	RB
cord-006860-a3b8hyyr	505	21	on	on	IN
cord-006860-a3b8hyyr	505	22	the	the	DT
cord-006860-a3b8hyyr	505	23	degree	degree	NN
cord-006860-a3b8hyyr	505	24	of	of	IN
cord-006860-a3b8hyyr	505	25	lateral	lateral	NNP
cord-006860-a3b8hyyr	505	26	association	association	NNP
cord-006860-a3b8hyyr	505	27	of	of	IN
cord-006860-a3b8hyyr	505	28	the	the	DT
cord-006860-a3b8hyyr	505	29	fibrin	fibrin	NN
cord-006860-a3b8hyyr	505	30	pmtofibdla	pmtofibdla	NNP
cord-006860-a3b8hyyr	505	31	.	.	.
cord-006860-a3b8hyyr	506	1	In	in	IN
cord-006860-a3b8hyyr	506	2	desAABB	desAABB	NNS
cord-006860-a3b8hyyr	506	3	-	-	HYPH
cord-006860-a3b8hyyr	506	4	fibrino	fibrino	RB
cord-006860-a3b8hyyr	506	5	no	no	DT
cord-006860-a3b8hyyr	506	6	lateral	lateral	JJ
cord-006860-a3b8hyyr	506	7	association	association	NNP
cord-006860-a3b8hyyr	506	8	of	of	IN
cord-006860-a3b8hyyr	506	9	fibrin	fibrin	NNP
cord-006860-a3b8hyyr	506	10	protofibnls	protofibnls	NN
cord-006860-a3b8hyyr	506	11	takes	take	VBZ
cord-006860-a3b8hyyr	506	12	place	place	NN
cord-006860-a3b8hyyr	506	13	under	under	IN
cord-006860-a3b8hyyr	506	14	the	the	DT
cord-006860-a3b8hyyr	506	15	conditions	condition	NNS
cord-006860-a3b8hyyr	506	16	chosen	choose	VBN
cord-006860-a3b8hyyr	506	17	here	here	RB
cord-006860-a3b8hyyr	506	18	.	.	.
cord-006860-a3b8hyyr	507	1	Thus	thus	RB
cord-006860-a3b8hyyr	507	2	it	-PRON-	PRP
cord-006860-a3b8hyyr	507	3	is	be	VBZ
cord-006860-a3b8hyyr	507	4	consistent	consistent	JJ
cord-006860-a3b8hyyr	507	5	with	with	IN
cord-006860-a3b8hyyr	507	6	our	-PRON-	PRP$
cord-006860-a3b8hyyr	507	7	theory	theory	NN
cord-006860-a3b8hyyr	507	8	that	that	IN
cord-006860-a3b8hyyr	507	9	we	-PRON-	PRP
cord-006860-a3b8hyyr	507	10	did	do	VBD
cord-006860-a3b8hyyr	507	11	not	not	RB
cord-006860-a3b8hyyr	507	12	observe	observe	VB
cord-006860-a3b8hyyr	507	13	any	any	DT
cord-006860-a3b8hyyr	507	14	binding	binding	NN
cord-006860-a3b8hyyr	507	15	of	of	IN
cord-006860-a3b8hyyr	507	16	aiAP	aiap	NN
cord-006860-a3b8hyyr	507	17	to	to	IN
cord-006860-a3b8hyyr	507	18	the	the	DT
cord-006860-a3b8hyyr	507	19	fibrin	fibrin	NN
cord-006860-a3b8hyyr	507	20	oligomers	oligomer	NNS
cord-006860-a3b8hyyr	507	21	of	of	IN
cord-006860-a3b8hyyr	507	22	desAABB	desAABB	NNS
cord-006860-a3b8hyyr	507	23	-	-	HYPH
cord-006860-a3b8hyyr	507	24	fibrino	fibrino	RB
cord-006860-a3b8hyyr	507	25	.	.	.
cord-006860-a3b8hyyr	508	1	Human	human	JJ
cord-006860-a3b8hyyr	508	2	PCI	PCI	NNP
cord-006860-a3b8hyyr	508	3	is	be	VBZ
cord-006860-a3b8hyyr	508	4	a	a	DT
cord-006860-a3b8hyyr	508	5	non	non	JJ
cord-006860-a3b8hyyr	508	6	-	-	JJ
cord-006860-a3b8hyyr	508	7	specific	specific	JJ
cord-006860-a3b8hyyr	508	8	serpin	serpin	NN
cord-006860-a3b8hyyr	508	9	that	that	WDT
cord-006860-a3b8hyyr	508	10	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	508	11	several	several	JJ
cord-006860-a3b8hyyr	508	12	proteases	protease	NNS
cord-006860-a3b8hyyr	508	13	of	of	IN
cord-006860-a3b8hyyr	508	14	the	the	DT
cord-006860-a3b8hyyr	508	15	coagulation	coagulation	NN
cord-006860-a3b8hyyr	508	16	and	and	CC
cord-006860-a3b8hyyr	508	17	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	508	18	systems	system	NNS
cord-006860-a3b8hyyr	508	19	as	as	RB
cord-006860-a3b8hyyr	508	20	well	well	RB
cord-006860-a3b8hyyr	508	21	as	as	IN
cord-006860-a3b8hyyr	508	22	tissue	tissue	NN
cord-006860-a3b8hyyr	508	23	kallikrein	kallikrein	NNP
cord-006860-a3b8hyyr	508	24	and	and	CC
cord-006860-a3b8hyyr	508	25	the	the	DT
cord-006860-a3b8hyyr	508	26	sperm	sperm	NN
cord-006860-a3b8hyyr	508	27	protease	protease	NN
cord-006860-a3b8hyyr	508	28	acrosin	acrosin	NNP
cord-006860-a3b8hyyr	508	29	.	.	.
cord-006860-a3b8hyyr	509	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	509	2	is	be	VBZ
cord-006860-a3b8hyyr	509	3	synthesized	synthesize	VBN
cord-006860-a3b8hyyr	509	4	in	in	IN
cord-006860-a3b8hyyr	509	5	many	many	JJ
cord-006860-a3b8hyyr	509	6	organs	organ	NNS
cord-006860-a3b8hyyr	509	7	including	include	VBG
cord-006860-a3b8hyyr	509	8	liver	liver	NN
cord-006860-a3b8hyyr	509	9	,	,	,
cord-006860-a3b8hyyr	509	10	pancreas	pancrea	NNS
cord-006860-a3b8hyyr	509	11	,	,	,
cord-006860-a3b8hyyr	509	12	and	and	CC
cord-006860-a3b8hyyr	509	13	testis	testis	NN
cord-006860-a3b8hyyr	509	14	.	.	.
cord-006860-a3b8hyyr	510	1	The	the	DT
cord-006860-a3b8hyyr	510	2	physiological	physiological	JJ
cord-006860-a3b8hyyr	510	3	role	role	NN
cord-006860-a3b8hyyr	510	4	of	of	IN
cord-006860-a3b8hyyr	510	5	PCI	PCI	NNP
cord-006860-a3b8hyyr	510	6	has	have	VBZ
cord-006860-a3b8hyyr	510	7	not	not	RB
cord-006860-a3b8hyyr	510	8	been	be	VBN
cord-006860-a3b8hyyr	510	9	defined	define	VBN
cord-006860-a3b8hyyr	510	10	yet	yet	RB
cord-006860-a3b8hyyr	510	11	.	.	.
cord-006860-a3b8hyyr	511	1	Recently	recently	RB
cord-006860-a3b8hyyr	511	2	,	,	,
cord-006860-a3b8hyyr	511	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	511	4	have	have	VBP
cord-006860-a3b8hyyr	511	5	cloned	clone	VBN
cord-006860-a3b8hyyr	511	6	and	and	CC
cord-006860-a3b8hyyr	511	7	sequenced	sequence	VBN
cord-006860-a3b8hyyr	511	8	the	the	DT
cord-006860-a3b8hyyr	511	9	mouse	mouse	NN
cord-006860-a3b8hyyr	511	10	PCI	pci	NN
cord-006860-a3b8hyyr	511	11	gene	gene	NN
cord-006860-a3b8hyyr	511	12	(	(	-LRB-
cord-006860-a3b8hyyr	511	13	Zechmeister	Zechmeister	NNP
cord-006860-a3b8hyyr	511	14	-	-	HYPH
cord-006860-a3b8hyyr	511	15	Machhart	Machhart	NNP
cord-006860-a3b8hyyr	511	16	etal	etal	NNP
cord-006860-a3b8hyyr	511	17	.	.	NNP
cord-006860-a3b8hyyr	511	18	,	,	,
cord-006860-a3b8hyyr	511	19	manuscript	manuscript	NN
cord-006860-a3b8hyyr	511	20	in	in	IN
cord-006860-a3b8hyyr	511	21	prep	prep	NN
cord-006860-a3b8hyyr	511	22	.	.	.
cord-006860-a3b8hyyr	511	23	)	)	-RRB-
cord-006860-a3b8hyyr	511	24	.	.	.
cord-006860-a3b8hyyr	512	1	This	this	DT
cord-006860-a3b8hyyr	512	2	enabled	enable	VBD
cord-006860-a3b8hyyr	512	3	us	-PRON-	PRP
cord-006860-a3b8hyyr	512	4	to	to	TO
cord-006860-a3b8hyyr	512	5	study	study	VB
cord-006860-a3b8hyyr	512	6	PCI	PCI	NNP
cord-006860-a3b8hyyr	512	7	gone	go	VBN
cord-006860-a3b8hyyr	512	8	expression	expression	NN
cord-006860-a3b8hyyr	512	9	in	in	IN
cord-006860-a3b8hyyr	512	10	murino	murino	NN
cord-006860-a3b8hyyr	512	11	tissues	tissue	NNS
cord-006860-a3b8hyyr	512	12	using	use	VBG
cord-006860-a3b8hyyr	512	13	mouse	mouse	NN
cord-006860-a3b8hyyr	512	14	PCI	pci	NN
cord-006860-a3b8hyyr	512	15	eDNA	edna	NN
cord-006860-a3b8hyyr	512	16	and	and	CC
cord-006860-a3b8hyyr	512	17	cRNA	cRNA	NNS
cord-006860-a3b8hyyr	512	18	probes	probe	NNS
cord-006860-a3b8hyyr	512	19	.	.	.
cord-006860-a3b8hyyr	513	1	By	by	IN
cord-006860-a3b8hyyr	513	2	Northern	northern	JJ
cord-006860-a3b8hyyr	513	3	blot	blot	NN
cord-006860-a3b8hyyr	513	4	analysis	analysis	NN
cord-006860-a3b8hyyr	513	5	,	,	,
cord-006860-a3b8hyyr	513	6	mouse	mouse	NN
cord-006860-a3b8hyyr	513	7	PCI	PCI	NNP
cord-006860-a3b8hyyr	513	8	taR.HA	taR.HA	NNP
cord-006860-a3b8hyyr	513	9	was	be	VBD
cord-006860-a3b8hyyr	513	10	exclusively	exclusively	RB
cord-006860-a3b8hyyr	513	11	found	find	VBN
cord-006860-a3b8hyyr	513	12	in	in	IN
cord-006860-a3b8hyyr	513	13	the	the	DT
cord-006860-a3b8hyyr	513	14	reproductive	reproductive	JJ
cord-006860-a3b8hyyr	513	15	tract	tract	NN
cord-006860-a3b8hyyr	513	16	(	(	-LRB-
cord-006860-a3b8hyyr	513	17	testis	testis	NN
cord-006860-a3b8hyyr	513	18	,	,	,
cord-006860-a3b8hyyr	513	19	seminal	seminal	JJ
cord-006860-a3b8hyyr	513	20	vesicle	vesicle	NN
cord-006860-a3b8hyyr	513	21	,	,	,
cord-006860-a3b8hyyr	513	22	ovary	ovary	NN
cord-006860-a3b8hyyr	513	23	)	)	-RRB-
cord-006860-a3b8hyyr	513	24	,	,	,
cord-006860-a3b8hyyr	513	25	all	all	DT
cord-006860-a3b8hyyr	513	26	other	other	JJ
cord-006860-a3b8hyyr	513	27	organs	organ	NNS
cord-006860-a3b8hyyr	513	28	analyzed	analyze	VBD
cord-006860-a3b8hyyr	513	29	-including	-include	VBG
cord-006860-a3b8hyyr	513	30	the	the	DT
cord-006860-a3b8hyyr	513	31	liver	liver	NN
cord-006860-a3b8hyyr	513	32	were	be	VBD
cord-006860-a3b8hyyr	513	33	negative	negative	JJ
cord-006860-a3b8hyyr	513	34	for	for	IN
cord-006860-a3b8hyyr	513	35	PCI	PCI	NNP
cord-006860-a3b8hyyr	513	36	mKNA	mkna	NN
cord-006860-a3b8hyyr	513	37	,	,	,
cord-006860-a3b8hyyr	513	38	indicating	indicate	VBG
cord-006860-a3b8hyyr	513	39	that	that	IN
cord-006860-a3b8hyyr	513	40	in	in	IN
cord-006860-a3b8hyyr	513	41	the	the	DT
cord-006860-a3b8hyyr	513	42	mouse	mouse	NN
cord-006860-a3b8hyyr	513	43	PCI	PCI	NNP
cord-006860-a3b8hyyr	513	44	is	be	VBZ
cord-006860-a3b8hyyr	513	45	not	not	RB
cord-006860-a3b8hyyr	513	46	a	a	DT
cord-006860-a3b8hyyr	513	47	plasma	plasma	NN
cord-006860-a3b8hyyr	513	48	protein	protein	NN
cord-006860-a3b8hyyr	513	49	.	.	.
cord-006860-a3b8hyyr	514	1	To	to	TO
cord-006860-a3b8hyyr	514	2	determine	determine	VB
cord-006860-a3b8hyyr	514	3	which	which	WDT
cord-006860-a3b8hyyr	514	4	cells	cell	NNS
cord-006860-a3b8hyyr	514	5	of	of	IN
cord-006860-a3b8hyyr	514	6	the	the	DT
cord-006860-a3b8hyyr	514	7	reproductive	reproductive	JJ
cord-006860-a3b8hyyr	514	8	tract	tract	NN
cord-006860-a3b8hyyr	514	9	synthesize	synthesize	VBP
cord-006860-a3b8hyyr	514	10	PCI	PCI	NNP
cord-006860-a3b8hyyr	514	11	,	,	,
cord-006860-a3b8hyyr	514	12	cellular	cellular	JJ
cord-006860-a3b8hyyr	514	13	localization	localization	NN
cord-006860-a3b8hyyr	514	14	was	be	VBD
cord-006860-a3b8hyyr	514	15	assessed	assess	VBN
cord-006860-a3b8hyyr	514	16	by	by	IN
cord-006860-a3b8hyyr	514	17	in	in	IN
cord-006860-a3b8hyyr	514	18	situ	situ	JJ
cord-006860-a3b8hyyr	514	19	hybridization	hybridization	NN
cord-006860-a3b8hyyr	514	20	of	of	IN
cord-006860-a3b8hyyr	514	21	mouse	mouse	NN
cord-006860-a3b8hyyr	514	22	testis	testis	NN
cord-006860-a3b8hyyr	514	23	and	and	CC
cord-006860-a3b8hyyr	514	24	ovary	ovary	JJ
cord-006860-a3b8hyyr	514	25	sections	section	NNS
cord-006860-a3b8hyyr	514	26	.	.	.
cord-006860-a3b8hyyr	515	1	In	in	IN
cord-006860-a3b8hyyr	515	2	testis	testis	NN
cord-006860-a3b8hyyr	515	3	,	,	,
cord-006860-a3b8hyyr	515	4	PCI	PCI	NNP
cord-006860-a3b8hyyr	515	5	mRNA	mrna	NN
cord-006860-a3b8hyyr	515	6	was	be	VBD
cord-006860-a3b8hyyr	515	7	present	present	JJ
cord-006860-a3b8hyyr	515	8	in	in	IN
cord-006860-a3b8hyyr	515	9	the	the	DT
cord-006860-a3b8hyyr	515	10	spermstogonia	spermstogonia	NNP
cord-006860-a3b8hyyr	515	11	layer	layer	NN
cord-006860-a3b8hyyr	515	12	and	and	CC
cord-006860-a3b8hyyr	515	13	in	in	IN
cord-006860-a3b8hyyr	515	14	Leydig	Leydig	NNP
cord-006860-a3b8hyyr	515	15	cells	cell	NNS
cord-006860-a3b8hyyr	515	16	,	,	,
cord-006860-a3b8hyyr	515	17	while	while	IN
cord-006860-a3b8hyyr	515	18	Sertoli	Sertoli	NNP
cord-006860-a3b8hyyr	515	19	cells	cell	NNS
cord-006860-a3b8hyyr	515	20	and	and	CC
cord-006860-a3b8hyyr	515	21	peritubular	peritubular	NNP
cord-006860-a3b8hyyr	515	22	myoid	myoid	NNP
cord-006860-a3b8hyyr	515	23	cells	cell	NNS
cord-006860-a3b8hyyr	515	24	were	be	VBD
cord-006860-a3b8hyyr	515	25	negative	negative	JJ
cord-006860-a3b8hyyr	515	26	.	.	.
cord-006860-a3b8hyyr	516	1	These	these	DT
cord-006860-a3b8hyyr	516	2	results	result	NNS
cord-006860-a3b8hyyr	516	3	are	be	VBP
cord-006860-a3b8hyyr	516	4	consistent	consistent	JJ
cord-006860-a3b8hyyr	516	5	with	with	IN
cord-006860-a3b8hyyr	516	6	the	the	DT
cord-006860-a3b8hyyr	516	7	immunohistological	immunohistological	NNP
cord-006860-a3b8hyyr	516	8	localization	localization	NN
cord-006860-a3b8hyyr	516	9	of	of	IN
cord-006860-a3b8hyyr	516	10	human	human	JJ
cord-006860-a3b8hyyr	516	11	PC1	PC1	NNP
cord-006860-a3b8hyyr	516	12	(	(	-LRB-
cord-006860-a3b8hyyr	516	13	Laurell	Laurell	NNP
cord-006860-a3b8hyyr	516	14	et	et	NNP
cord-006860-a3b8hyyr	516	15	al	al	NNP
cord-006860-a3b8hyyr	516	16	,	,	,
cord-006860-a3b8hyyr	516	17	,	,	,
cord-006860-a3b8hyyr	516	18	1992	1992	CD
cord-006860-a3b8hyyr	516	19	)	)	-RRB-
cord-006860-a3b8hyyr	516	20	.	.	.
cord-006860-a3b8hyyr	517	1	In	in	IN
cord-006860-a3b8hyyr	517	2	the	the	DT
cord-006860-a3b8hyyr	517	3	mouse	mouse	NN
cord-006860-a3b8hyyr	517	4	ovary	ovary	NN
cord-006860-a3b8hyyr	517	5	,	,	,
cord-006860-a3b8hyyr	517	6	stroma	stroma	NN
cord-006860-a3b8hyyr	517	7	cells	cell	NNS
cord-006860-a3b8hyyr	517	8	of	of	IN
cord-006860-a3b8hyyr	517	9	the	the	DT
cord-006860-a3b8hyyr	517	10	medulla	medulla	NN
cord-006860-a3b8hyyr	517	11	and	and	CC
cord-006860-a3b8hyyr	517	12	around	around	IN
cord-006860-a3b8hyyr	517	13	the	the	DT
cord-006860-a3b8hyyr	517	14	follicles	follicle	NNS
cord-006860-a3b8hyyr	517	15	were	be	VBD
cord-006860-a3b8hyyr	517	16	positive	positive	JJ
cord-006860-a3b8hyyr	517	17	for	for	IN
cord-006860-a3b8hyyr	517	18	PCI	PCI	NNP
cord-006860-a3b8hyyr	517	19	mRNA	mrna	NN
cord-006860-a3b8hyyr	517	20	.	.	.
cord-006860-a3b8hyyr	518	1	No	no	DT
cord-006860-a3b8hyyr	518	2	PCI	pci	NN
cord-006860-a3b8hyyr	518	3	expression	expression	NN
cord-006860-a3b8hyyr	518	4	was	be	VBD
cord-006860-a3b8hyyr	518	5	detected	detect	VBN
cord-006860-a3b8hyyr	518	6	in	in	IN
cord-006860-a3b8hyyr	518	7	theca	theca	NN
cord-006860-a3b8hyyr	518	8	or	or	CC
cord-006860-a3b8hyyr	518	9	granulosa	granulosa	JJ
cord-006860-a3b8hyyr	518	10	cells	cell	NNS
cord-006860-a3b8hyyr	518	11	.	.	.
cord-006860-a3b8hyyr	519	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	519	2	also	also	RB
cord-006860-a3b8hyyr	519	3	studied	study	VBD
cord-006860-a3b8hyyr	519	4	the	the	DT
cord-006860-a3b8hyyr	519	5	regulation	regulation	NN
cord-006860-a3b8hyyr	519	6	of	of	IN
cord-006860-a3b8hyyr	519	7	mouse	mouse	NN
cord-006860-a3b8hyyr	519	8	PCI	PCI	NNP
cord-006860-a3b8hyyr	519	9	gone	go	VBN
cord-006860-a3b8hyyr	519	10	expression	expression	NN
cord-006860-a3b8hyyr	519	11	by	by	IN
cord-006860-a3b8hyyr	519	12	steroid	steroid	NN
cord-006860-a3b8hyyr	519	13	hormones	hormone	NNS
cord-006860-a3b8hyyr	519	14	in	in	IN
cord-006860-a3b8hyyr	519	15	vivo	vivo	NNP
cord-006860-a3b8hyyr	519	16	.	.	.
cord-006860-a3b8hyyr	520	1	[	[	-LRB-
cord-006860-a3b8hyyr	520	2	n	n	CC
cord-006860-a3b8hyyr	520	3	mature	mature	JJ
cord-006860-a3b8hyyr	520	4	male	male	JJ
cord-006860-a3b8hyyr	520	5	mice	mouse	NNS
cord-006860-a3b8hyyr	520	6	castration	castration	NN
cord-006860-a3b8hyyr	520	7	caused	cause	VBD
cord-006860-a3b8hyyr	520	8	an	an	DT
cord-006860-a3b8hyyr	520	9	increase	increase	NN
cord-006860-a3b8hyyr	520	10	in	in	IN
cord-006860-a3b8hyyr	520	11	PCI	pci	NN
cord-006860-a3b8hyyr	520	12	mRNA	mrna	NN
cord-006860-a3b8hyyr	520	13	in	in	IN
cord-006860-a3b8hyyr	520	14	seminal	seminal	JJ
cord-006860-a3b8hyyr	520	15	vesicles	vesicle	NNS
cord-006860-a3b8hyyr	520	16	,	,	,
cord-006860-a3b8hyyr	520	17	which	which	WDT
cord-006860-a3b8hyyr	520	18	was	be	VBD
cord-006860-a3b8hyyr	520	19	reversible	reversible	JJ
cord-006860-a3b8hyyr	520	20	upon	upon	IN
cord-006860-a3b8hyyr	520	21	the	the	DT
cord-006860-a3b8hyyr	520	22	administration	administration	NN
cord-006860-a3b8hyyr	520	23	of	of	IN
cord-006860-a3b8hyyr	520	24	testosterone	testosterone	NN
cord-006860-a3b8hyyr	520	25	.	.	.
cord-006860-a3b8hyyr	521	1	In	in	IN
cord-006860-a3b8hyyr	521	2	tissues	tissue	NNS
cord-006860-a3b8hyyr	521	3	of	of	IN
cord-006860-a3b8hyyr	521	4	intact	intact	JJ
cord-006860-a3b8hyyr	521	5	adult	adult	NN
cord-006860-a3b8hyyr	521	6	male	male	JJ
cord-006860-a3b8hyyr	521	7	and	and	CC
cord-006860-a3b8hyyr	521	8	female	female	JJ
cord-006860-a3b8hyyr	521	9	mice	mouse	NNS
cord-006860-a3b8hyyr	521	10	,	,	,
cord-006860-a3b8hyyr	521	11	PCI	pci	NN
cord-006860-a3b8hyyr	521	12	mRNA	mrna	NN
cord-006860-a3b8hyyr	521	13	levels	level	NNS
cord-006860-a3b8hyyr	521	14	decreased	decrease	VBD
cord-006860-a3b8hyyr	521	15	after	after	IN
cord-006860-a3b8hyyr	521	16	injection	injection	NN
cord-006860-a3b8hyyr	521	17	of	of	IN
cord-006860-a3b8hyyr	521	18	human	human	JJ
cord-006860-a3b8hyyr	521	19	chorionic	chorionic	NN
cord-006860-a3b8hyyr	521	20	gonedotropin	gonedotropin	NN
cord-006860-a3b8hyyr	521	21	(	(	-LRB-
cord-006860-a3b8hyyr	521	22	hCG	hCG	NNP
cord-006860-a3b8hyyr	521	23	)	)	-RRB-
cord-006860-a3b8hyyr	521	24	,	,	,
cord-006860-a3b8hyyr	521	25	while	while	IN
cord-006860-a3b8hyyr	521	26	in	in	IN
cord-006860-a3b8hyyr	521	27	castrated	castrate	VBN
cord-006860-a3b8hyyr	521	28	male	male	JJ
cord-006860-a3b8hyyr	521	29	mice	mouse	NNS
cord-006860-a3b8hyyr	521	30	,	,	,
cord-006860-a3b8hyyr	521	31	hCO	hCO	NNP
cord-006860-a3b8hyyr	521	32	had	have	VBD
cord-006860-a3b8hyyr	521	33	no	no	DT
cord-006860-a3b8hyyr	521	34	effect	effect	NN
cord-006860-a3b8hyyr	521	35	on	on	IN
cord-006860-a3b8hyyr	521	36	seminal	seminal	JJ
cord-006860-a3b8hyyr	521	37	vesicle	vesicle	NN
cord-006860-a3b8hyyr	521	38	PCI	pci	NN
cord-006860-a3b8hyyr	521	39	mRNA	mrna	NN
cord-006860-a3b8hyyr	521	40	.	.	.
cord-006860-a3b8hyyr	522	1	Progesterone	progesterone	NN
cord-006860-a3b8hyyr	522	2	and	and	CC
cord-006860-a3b8hyyr	522	3	17-B	17-b	JJ
cord-006860-a3b8hyyr	522	4	estradiol	estradiol	NN
cord-006860-a3b8hyyr	522	5	decreased	decrease	VBD
cord-006860-a3b8hyyr	522	6	ovarian	ovarian	JJ
cord-006860-a3b8hyyr	522	7	PCI	pci	NN
cord-006860-a3b8hyyr	522	8	mRNA	mrna	NN
cord-006860-a3b8hyyr	522	9	levels	level	NNS
cord-006860-a3b8hyyr	522	10	in	in	IN
cord-006860-a3b8hyyr	522	11	immature	immature	JJ
cord-006860-a3b8hyyr	522	12	female	female	JJ
cord-006860-a3b8hyyr	522	13	mice	mouse	NNS
cord-006860-a3b8hyyr	522	14	.	.	.
cord-006860-a3b8hyyr	523	1	These	these	DT
cord-006860-a3b8hyyr	523	2	data	datum	NNS
cord-006860-a3b8hyyr	523	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	523	4	direct	direct	JJ
cord-006860-a3b8hyyr	523	5	down	down	JJ
cord-006860-a3b8hyyr	523	6	-	-	HYPH
cord-006860-a3b8hyyr	523	7	regulation	regulation	NN
cord-006860-a3b8hyyr	523	8	of	of	IN
cord-006860-a3b8hyyr	523	9	mouse	mouse	NN
cord-006860-a3b8hyyr	523	10	PCI	PCI	NNP
cord-006860-a3b8hyyr	523	11	by	by	IN
cord-006860-a3b8hyyr	523	12	sex	sex	NN
cord-006860-a3b8hyyr	523	13	steroids	steroid	NNS
cord-006860-a3b8hyyr	523	14	.	.	.
cord-006860-a3b8hyyr	524	1	The	the	DT
cord-006860-a3b8hyyr	524	2	different	different	JJ
cord-006860-a3b8hyyr	524	3	tissue	tissue	NN
cord-006860-a3b8hyyr	524	4	specific	specific	JJ
cord-006860-a3b8hyyr	524	5	PCI	pci	NN
cord-006860-a3b8hyyr	524	6	-	-	HYPH
cord-006860-a3b8hyyr	524	7	geoe	geoe	NN
cord-006860-a3b8hyyr	524	8	expression	expression	NN
cord-006860-a3b8hyyr	524	9	in	in	IN
cord-006860-a3b8hyyr	524	10	men	man	NNS
cord-006860-a3b8hyyr	524	11	and	and	CC
cord-006860-a3b8hyyr	524	12	mice	mouse	NNS
cord-006860-a3b8hyyr	524	13	furthermore	furthermore	RB
cord-006860-a3b8hyyr	524	14	indicates	indicate	VBZ
cord-006860-a3b8hyyr	524	15	a	a	DT
cord-006860-a3b8hyyr	524	16	different	different	JJ
cord-006860-a3b8hyyr	524	17	biological	biological	JJ
cord-006860-a3b8hyyr	524	18	role	role	NN
cord-006860-a3b8hyyr	524	19	of	of	IN
cord-006860-a3b8hyyr	524	20	this	this	DT
cord-006860-a3b8hyyr	524	21	serpin	serpin	NN
cord-006860-a3b8hyyr	524	22	in	in	IN
cord-006860-a3b8hyyr	524	23	the	the	DT
cord-006860-a3b8hyyr	524	24	two	two	CD
cord-006860-a3b8hyyr	524	25	species	specie	NNS
cord-006860-a3b8hyyr	524	26	.	.	.
cord-006860-a3b8hyyr	525	1	Ctr	Ctr	NNP
cord-006860-a3b8hyyr	525	2	.	.	.
cord-006860-a3b8hyyr	526	1	Transgene	Transgene	NNP
cord-006860-a3b8hyyr	526	2	Technology	Technology	NNP
cord-006860-a3b8hyyr	526	3	,	,	,
cord-006860-a3b8hyyr	526	4	Leuven	Leuven	NNP
cord-006860-a3b8hyyr	526	5	"	"	''
cord-006860-a3b8hyyr	526	6	[	[	-LRB-
cord-006860-a3b8hyyr	526	7	'	'	''
cord-006860-a3b8hyyr	526	8	1-Tissue	1-tissue	CD
cord-006860-a3b8hyyr	526	9	factor	factor	NN
cord-006860-a3b8hyyr	526	10	(	(	-LRB-
cord-006860-a3b8hyyr	526	11	'	'	``
cord-006860-a3b8hyyr	526	12	IT	it	NN
cord-006860-a3b8hyyr	526	13	)	)	-RRB-
cord-006860-a3b8hyyr	526	14	is	be	VBZ
cord-006860-a3b8hyyr	526	15	a	a	DT
cord-006860-a3b8hyyr	526	16	47	47	CD
cord-006860-a3b8hyyr	526	17	kDA	kda	NN
cord-006860-a3b8hyyr	526	18	glycoprotein	glycoprotein	NN
cord-006860-a3b8hyyr	526	19	mainly	mainly	RB
cord-006860-a3b8hyyr	526	20	known	know	VBN
cord-006860-a3b8hyyr	526	21	a	a	DT
cord-006860-a3b8hyyr	526	22	the	the	DT
cord-006860-a3b8hyyr	526	23	primary	primary	JJ
cord-006860-a3b8hyyr	526	24	cellular	cellular	JJ
cord-006860-a3b8hyyr	526	25	initiator	initiator	NN
cord-006860-a3b8hyyr	526	26	of	of	IN
cord-006860-a3b8hyyr	526	27	blood	blood	NN
cord-006860-a3b8hyyr	526	28	coagulation	coagulation	NN
cord-006860-a3b8hyyr	526	29	.	.	.
cord-006860-a3b8hyyr	527	1	Whether	whether	IN
cord-006860-a3b8hyyr	527	2	TF	TF	NNP
cord-006860-a3b8hyyr	527	3	expression	expression	NN
cord-006860-a3b8hyyr	527	4	may	may	MD
cord-006860-a3b8hyyr	527	5	also	also	RB
cord-006860-a3b8hyyr	527	6	play	play	VB
cord-006860-a3b8hyyr	527	7	a	a	DT
cord-006860-a3b8hyyr	527	8	role	role	NN
cord-006860-a3b8hyyr	527	9	in	in	IN
cord-006860-a3b8hyyr	527	10	development	development	NN
cord-006860-a3b8hyyr	527	11	is	be	VBZ
cord-006860-a3b8hyyr	527	12	unknown	unknown	JJ
cord-006860-a3b8hyyr	527	13	,	,	,
cord-006860-a3b8hyyr	527	14	but	but	CC
cord-006860-a3b8hyyr	527	15	the	the	DT
cord-006860-a3b8hyyr	527	16	lack	lack	NN
cord-006860-a3b8hyyr	527	17	of	of	IN
cord-006860-a3b8hyyr	527	18	spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	527	19	viable	viable	JJ
cord-006860-a3b8hyyr	527	20	mutations	mutation	NNS
cord-006860-a3b8hyyr	527	21	of	of	IN
cord-006860-a3b8hyyr	527	22	the	the	DT
cord-006860-a3b8hyyr	527	23	TF	TF	NNP
cord-006860-a3b8hyyr	527	24	gene	gene	NN
cord-006860-a3b8hyyr	527	25	in	in	IN
cord-006860-a3b8hyyr	527	26	rive	rive	NNP
cord-006860-a3b8hyyr	527	27	leads	lead	VBZ
cord-006860-a3b8hyyr	527	28	to	to	IN
cord-006860-a3b8hyyr	527	29	the	the	DT
cord-006860-a3b8hyyr	527	30	speculation	speculation	NN
cord-006860-a3b8hyyr	527	31	that	that	IN
cord-006860-a3b8hyyr	527	32	its	-PRON-	PRP$
cord-006860-a3b8hyyr	527	33	absence	absence	NN
cord-006860-a3b8hyyr	527	34	may	may	MD
cord-006860-a3b8hyyr	527	35	not	not	RB
cord-006860-a3b8hyyr	527	36	be	be	VB
cord-006860-a3b8hyyr	527	37	compatible	compatible	JJ
cord-006860-a3b8hyyr	527	38	with	with	IN
cord-006860-a3b8hyyr	527	39	normal	normal	JJ
cord-006860-a3b8hyyr	527	40	embryonic	embryonic	JJ
cord-006860-a3b8hyyr	527	41	development	development	NN
cord-006860-a3b8hyyr	527	42	.	.	.
cord-006860-a3b8hyyr	528	1	To	to	TO
cord-006860-a3b8hyyr	528	2	determine	determine	VB
cord-006860-a3b8hyyr	528	3	the	the	DT
cord-006860-a3b8hyyr	528	4	significance	significance	NN
cord-006860-a3b8hyyr	528	5	of	of	IN
cord-006860-a3b8hyyr	528	6	"	"	``
cord-006860-a3b8hyyr	528	7	IF	if	IN
cord-006860-a3b8hyyr	528	8	in	in	IN
cord-006860-a3b8hyyr	528	9	ontogenesis	ontogenesis	NN
cord-006860-a3b8hyyr	528	10	,	,	,
cord-006860-a3b8hyyr	528	11	the	the	DT
cord-006860-a3b8hyyr	528	12	pattern	pattern	NN
cord-006860-a3b8hyyr	528	13	of	of	IN
cord-006860-a3b8hyyr	528	14	TF	TF	NNP
cord-006860-a3b8hyyr	528	15	expression	expression	NN
cord-006860-a3b8hyyr	528	16	in	in	IN
cord-006860-a3b8hyyr	528	17	mouse	mouse	NN
cord-006860-a3b8hyyr	528	18	development	development	NN
cord-006860-a3b8hyyr	528	19	was	be	VBD
cord-006860-a3b8hyyr	528	20	examined	examine	VBN
cord-006860-a3b8hyyr	528	21	and	and	CC
cord-006860-a3b8hyyr	528	22	compared	compare	VBN
cord-006860-a3b8hyyr	528	23	to	to	IN
cord-006860-a3b8hyyr	528	24	the	the	DT
cord-006860-a3b8hyyr	528	25	'	'	``
cord-006860-a3b8hyyr	528	26	IF	if	IN
cord-006860-a3b8hyyr	528	27	distribution	distribution	NN
cord-006860-a3b8hyyr	528	28	in	in	IN
cord-006860-a3b8hyyr	528	29	human	human	JJ
cord-006860-a3b8hyyr	528	30	postlmplantation	postlmplantation	NN
cord-006860-a3b8hyyr	528	31	embryos	embryo	NNS
cord-006860-a3b8hyyr	528	32	and	and	CC
cord-006860-a3b8hyyr	528	33	fetuses	fetus	NNS
cord-006860-a3b8hyyr	528	34	of	of	IN
cord-006860-a3b8hyyr	528	35	corresponding	correspond	VBG
cord-006860-a3b8hyyr	528	36	gestational	gestational	JJ
cord-006860-a3b8hyyr	528	37	age	age	NN
cord-006860-a3b8hyyr	528	38	.	.	.
cord-006860-a3b8hyyr	529	1	At	at	IN
cord-006860-a3b8hyyr	529	2	early	early	JJ
cord-006860-a3b8hyyr	529	3	embryonic	embryonic	JJ
cord-006860-a3b8hyyr	529	4	period	period	NN
cord-006860-a3b8hyyr	529	5	of	of	IN
cord-006860-a3b8hyyr	529	6	both	both	DT
cord-006860-a3b8hyyr	529	7	murine	murine	JJ
cord-006860-a3b8hyyr	529	8	(	(	-LRB-
cord-006860-a3b8hyyr	529	9	6.5	6.5	CD
cord-006860-a3b8hyyr	529	10	and	and	CC
cord-006860-a3b8hyyr	529	11	7.5	7.5	CD
cord-006860-a3b8hyyr	529	12	pc	pc	NN
cord-006860-a3b8hyyr	529	13	)	)	-RRB-
cord-006860-a3b8hyyr	529	14	and	and	CC
cord-006860-a3b8hyyr	529	15	human	human	JJ
cord-006860-a3b8hyyr	529	16	(	(	-LRB-
cord-006860-a3b8hyyr	529	17	stage	stage	NN
cord-006860-a3b8hyyr	529	18	5	5	CD
cord-006860-a3b8hyyr	529	19	)	)	-RRB-
cord-006860-a3b8hyyr	529	20	development	development	NN
cord-006860-a3b8hyyr	529	21	there	there	EX
cord-006860-a3b8hyyr	529	22	is	be	VBZ
cord-006860-a3b8hyyr	529	23	a	a	DT
cord-006860-a3b8hyyr	529	24	strong	strong	JJ
cord-006860-a3b8hyyr	529	25	TF	TF	NNP
cord-006860-a3b8hyyr	529	26	expression	expression	NN
cord-006860-a3b8hyyr	529	27	in	in	IN
cord-006860-a3b8hyyr	529	28	both	both	DT
cord-006860-a3b8hyyr	529	29	ectodermal	ectodermal	NNS
cord-006860-a3b8hyyr	529	30	and	and	CC
cord-006860-a3b8hyyr	529	31	entodermal	entodermal	JJ
cord-006860-a3b8hyyr	529	32	cells	cell	NNS
cord-006860-a3b8hyyr	529	33	.	.	.
cord-006860-a3b8hyyr	530	1	"	"	``
cord-006860-a3b8hyyr	530	2	IF	if	IN
cord-006860-a3b8hyyr	530	3	decoration	decoration	NN
cord-006860-a3b8hyyr	530	4	was	be	VBD
cord-006860-a3b8hyyr	530	5	seen	see	VBN
cord-006860-a3b8hyyr	530	6	during	during	IN
cord-006860-a3b8hyyr	530	7	ontogenetic	ontogenetic	JJ
cord-006860-a3b8hyyr	530	8	development	development	NN
cord-006860-a3b8hyyr	530	9	in	in	IN
cord-006860-a3b8hyyr	530	10	tissues	tissue	NNS
cord-006860-a3b8hyyr	530	11	such	such	JJ
cord-006860-a3b8hyyr	530	12	as	as	IN
cord-006860-a3b8hyyr	530	13	epidermis	epidermis	NN
cord-006860-a3b8hyyr	530	14	,	,	,
cord-006860-a3b8hyyr	530	15	myocardium	myocardium	NN
cord-006860-a3b8hyyr	530	16	,	,	,
cord-006860-a3b8hyyr	530	17	bronchial	bronchial	JJ
cord-006860-a3b8hyyr	530	18	epithelium	epithelium	NN
cord-006860-a3b8hyyr	530	19	,	,	,
cord-006860-a3b8hyyr	530	20	and	and	CC
cord-006860-a3b8hyyr	530	21	hepatocytes	hepatocyte	NNS
cord-006860-a3b8hyyr	530	22	,	,	,
cord-006860-a3b8hyyr	530	23	which	which	WDT
cord-006860-a3b8hyyr	530	24	express	express	VBP
cord-006860-a3b8hyyr	530	25	"	"	``
cord-006860-a3b8hyyr	530	26	IF	if	IN
cord-006860-a3b8hyyr	530	27	in	in	IN
cord-006860-a3b8hyyr	530	28	the	the	DT
cord-006860-a3b8hyyr	530	29	adult	adult	NN
cord-006860-a3b8hyyr	530	30	organism	organism	NN
cord-006860-a3b8hyyr	530	31	.	.	.
cord-006860-a3b8hyyr	531	1	Surprisingly	surprisingly	RB
cord-006860-a3b8hyyr	531	2	,	,	,
cord-006860-a3b8hyyr	531	3	during	during	IN
cord-006860-a3b8hyyr	531	4	renal	renal	JJ
cord-006860-a3b8hyyr	531	5	development	development	NN
cord-006860-a3b8hyyr	531	6	and	and	CC
cord-006860-a3b8hyyr	531	7	in	in	IN
cord-006860-a3b8hyyr	531	8	adult	adult	NN
cord-006860-a3b8hyyr	531	9	organism	organism	NN
cord-006860-a3b8hyyr	531	10	TF	TF	NNP
cord-006860-a3b8hyyr	531	11	expression	expression	NN
cord-006860-a3b8hyyr	531	12	differs	differ	VBZ
cord-006860-a3b8hyyr	531	13	between	between	IN
cord-006860-a3b8hyyr	531	14	men	man	NNS
cord-006860-a3b8hyyr	531	15	and	and	CC
cord-006860-a3b8hyyr	531	16	mice	mouse	NNS
cord-006860-a3b8hyyr	531	17	.	.	.
cord-006860-a3b8hyyr	532	1	In	in	IN
cord-006860-a3b8hyyr	532	2	humans	human	NNS
cord-006860-a3b8hyyr	532	3	maturing	mature	VBG
cord-006860-a3b8hyyr	532	4	stage	stage	NN
cord-006860-a3b8hyyr	532	5	glomerali	glomerali	NNP
cord-006860-a3b8hyyr	532	6	were	be	VBD
cord-006860-a3b8hyyr	532	7	"	"	``
cord-006860-a3b8hyyr	532	8	IF	if	IN
cord-006860-a3b8hyyr	532	9	positive	positive	JJ
cord-006860-a3b8hyyr	532	10	whereas	wherea	NNS
cord-006860-a3b8hyyr	532	11	in	in	IN
cord-006860-a3b8hyyr	532	12	mice	mice	NN
cord-006860-a3b8hyyr	532	13	glomeruli	glomerulus	NNS
cord-006860-a3b8hyyr	532	14	were	be	VBD
cord-006860-a3b8hyyr	532	15	negative	negative	JJ
cord-006860-a3b8hyyr	532	16	and	and	CC
cord-006860-a3b8hyyr	532	17	instead	instead	RB
cord-006860-a3b8hyyr	532	18	epithelia	epithelium	NNS
cord-006860-a3b8hyyr	532	19	of	of	IN
cord-006860-a3b8hyyr	532	20	tubular	tubular	JJ
cord-006860-a3b8hyyr	532	21	segments	segment	NNS
cord-006860-a3b8hyyr	532	22	were	be	VBD
cord-006860-a3b8hyyr	532	23	TF	TF	NNP
cord-006860-a3b8hyyr	532	24	positive	positive	JJ
cord-006860-a3b8hyyr	532	25	.	.	.
cord-006860-a3b8hyyr	533	1	In	in	IN
cord-006860-a3b8hyyr	533	2	ncuroepithelial	ncuroepithelial	JJ
cord-006860-a3b8hyyr	533	3	cells	cell	NNS
cord-006860-a3b8hyyr	533	4	there	there	EX
cord-006860-a3b8hyyr	533	5	was	be	VBD
cord-006860-a3b8hyyr	533	6	a	a	DT
cord-006860-a3b8hyyr	533	7	striking	striking	JJ
cord-006860-a3b8hyyr	533	8	'	'	''
cord-006860-a3b8hyyr	533	9	IF	if	IN
cord-006860-a3b8hyyr	533	10	expression	expression	NN
cord-006860-a3b8hyyr	533	11	indicating	indicate	VBG
cord-006860-a3b8hyyr	533	12	a	a	DT
cord-006860-a3b8hyyr	533	13	possible	possible	JJ
cord-006860-a3b8hyyr	533	14	role	role	NN
cord-006860-a3b8hyyr	533	15	of'IF	of'if	ADD
cord-006860-a3b8hyyr	533	16	in	in	IN
cord-006860-a3b8hyyr	533	17	neumlation	neumlation	NN
cord-006860-a3b8hyyr	533	18	.	.	.
cord-006860-a3b8hyyr	534	1	Moreover	moreover	RB
cord-006860-a3b8hyyr	534	2	,	,	,
cord-006860-a3b8hyyr	534	3	there	there	EX
cord-006860-a3b8hyyr	534	4	was	be	VBD
cord-006860-a3b8hyyr	534	5	a	a	DT
cord-006860-a3b8hyyr	534	6	robust	robust	JJ
cord-006860-a3b8hyyr	534	7	TF	TF	NNP
cord-006860-a3b8hyyr	534	8	expression	expression	NN
cord-006860-a3b8hyyr	534	9	in	in	IN
cord-006860-a3b8hyyr	534	10	tissues	tissue	NNS
cord-006860-a3b8hyyr	534	11	such	such	JJ
cord-006860-a3b8hyyr	534	12	as	as	IN
cord-006860-a3b8hyyr	534	13	skeletal	skeletal	JJ
cord-006860-a3b8hyyr	534	14	muscle	muscle	NN
cord-006860-a3b8hyyr	534	15	,	,	,
cord-006860-a3b8hyyr	534	16	and	and	CC
cord-006860-a3b8hyyr	534	17	pancreas	pancrea	NNS
cord-006860-a3b8hyyr	534	18	,	,	,
cord-006860-a3b8hyyr	534	19	which	which	WDT
cord-006860-a3b8hyyr	534	20	do	do	VBP
cord-006860-a3b8hyyr	534	21	not	not	RB
cord-006860-a3b8hyyr	534	22	express	express	VB
cord-006860-a3b8hyyr	534	23	in	in	IN
cord-006860-a3b8hyyr	534	24	adult	adult	NN
cord-006860-a3b8hyyr	534	25	.	.	.
cord-006860-a3b8hyyr	535	1	In	in	IN
cord-006860-a3b8hyyr	535	2	contrast	contrast	NN
cord-006860-a3b8hyyr	535	3	to	to	IN
cord-006860-a3b8hyyr	535	4	TF	TF	NNP
cord-006860-a3b8hyyr	535	5	,	,	,
cord-006860-a3b8hyyr	535	6	its	-PRON-	PRP$
cord-006860-a3b8hyyr	535	7	physiologic	physiologic	JJ
cord-006860-a3b8hyyr	535	8	ligand	ligand	NN
cord-006860-a3b8hyyr	535	9	factor	factor	NN
cord-006860-a3b8hyyr	535	10	VII	VII	NNP
cord-006860-a3b8hyyr	535	11	was	be	VBD
cord-006860-a3b8hyyr	535	12	not	not	RB
cord-006860-a3b8hyyr	535	13	expressed	express	VBN
cord-006860-a3b8hyyr	535	14	in	in	IN
cord-006860-a3b8hyyr	535	15	early	early	JJ
cord-006860-a3b8hyyr	535	16	stages	stage	NNS
cord-006860-a3b8hyyr	535	17	of	of	IN
cord-006860-a3b8hyyr	535	18	human	human	JJ
cord-006860-a3b8hyyr	535	19	embryogenesis	embryogenesis	NN
cord-006860-a3b8hyyr	535	20	,	,	,
cord-006860-a3b8hyyr	535	21	but	but	CC
cord-006860-a3b8hyyr	535	22	was	be	VBD
cord-006860-a3b8hyyr	535	23	detectable	detectable	JJ
cord-006860-a3b8hyyr	535	24	in	in	IN
cord-006860-a3b8hyyr	535	25	fetal	fetal	JJ
cord-006860-a3b8hyyr	535	26	liver	liver	NN
cord-006860-a3b8hyyr	535	27	,	,	,
cord-006860-a3b8hyyr	535	28	The	the	DT
cord-006860-a3b8hyyr	535	29	temporal	temporal	JJ
cord-006860-a3b8hyyr	535	30	and	and	CC
cord-006860-a3b8hyyr	535	31	spatial	spatial	JJ
cord-006860-a3b8hyyr	535	32	pattern	pattern	NN
cord-006860-a3b8hyyr	535	33	of	of	IN
cord-006860-a3b8hyyr	535	34	TF	TF	NNP
cord-006860-a3b8hyyr	535	35	expression	expression	NN
cord-006860-a3b8hyyr	535	36	during	during	IN
cord-006860-a3b8hyyr	535	37	murine	murine	JJ
cord-006860-a3b8hyyr	535	38	and	and	CC
cord-006860-a3b8hyyr	535	39	human	human	JJ
cord-006860-a3b8hyyr	535	40	development	development	NN
cord-006860-a3b8hyyr	535	41	support	support	VBP
cord-006860-a3b8hyyr	535	42	the	the	DT
cord-006860-a3b8hyyr	535	43	hypothesis	hypothesis	NN
cord-006860-a3b8hyyr	535	44	,	,	,
cord-006860-a3b8hyyr	535	45	that	that	IN
cord-006860-a3b8hyyr	535	46	'	'	``
cord-006860-a3b8hyyr	535	47	IF	if	IN
cord-006860-a3b8hyyr	535	48	serves	serve	VBZ
cord-006860-a3b8hyyr	535	49	as	as	IN
cord-006860-a3b8hyyr	535	50	an	an	DT
cord-006860-a3b8hyyr	535	51	important	important	JJ
cord-006860-a3b8hyyr	535	52	mo	mo	NN
cord-006860-a3b8hyyr	535	53	~	~	NFP
cord-006860-a3b8hyyr	535	54	hoJzenic	hoJzenic	NNP
cord-006860-a3b8hyyr	535	55	factor	factor	NN
cord-006860-a3b8hyyr	535	56	darinz	darinz	NNP
cord-006860-a3b8hyyr	535	57	embrvozenesis	embrvozenesis	NN
cord-006860-a3b8hyyr	535	58	.	.	.
cord-006860-a3b8hyyr	536	1	To	to	TO
cord-006860-a3b8hyyr	536	2	serve	serve	VB
cord-006860-a3b8hyyr	536	3	as	as	IN
cord-006860-a3b8hyyr	536	4	an	an	DT
cord-006860-a3b8hyyr	536	5	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	536	6	,	,	,
cord-006860-a3b8hyyr	536	7	protein	protein	NN
cord-006860-a3b8hyyr	536	8	C	C	NNP
cord-006860-a3b8hyyr	536	9	(	(	-LRB-
cord-006860-a3b8hyyr	536	10	PC	PC	NNP
cord-006860-a3b8hyyr	536	11	)	)	-RRB-
cord-006860-a3b8hyyr	536	12	must	must	MD
cord-006860-a3b8hyyr	536	13	be	be	VB
cord-006860-a3b8hyyr	536	14	activated	activate	VBN
cord-006860-a3b8hyyr	536	15	by	by	IN
cord-006860-a3b8hyyr	536	16	a	a	DT
cord-006860-a3b8hyyr	536	17	complex	complex	NN
cord-006860-a3b8hyyr	536	18	formed	form	VBN
cord-006860-a3b8hyyr	536	19	between	between	IN
cord-006860-a3b8hyyr	536	20	the	the	DT
cord-006860-a3b8hyyr	536	21	enzyme	enzyme	NN
cord-006860-a3b8hyyr	536	22	thrombin	thrombin	NN
cord-006860-a3b8hyyr	536	23	(	(	-LRB-
cord-006860-a3b8hyyr	536	24	T	T	NNP
cord-006860-a3b8hyyr	536	25	)	)	-RRB-
cord-006860-a3b8hyyr	536	26	and	and	CC
cord-006860-a3b8hyyr	536	27	its	-PRON-	PRP$
cord-006860-a3b8hyyr	536	28	cofactor	cofactor	NN
cord-006860-a3b8hyyr	536	29	thrombomodulin	thrombomodulin	NN
cord-006860-a3b8hyyr	536	30	(	(	-LRB-
cord-006860-a3b8hyyr	536	31	TM	TM	NNP
cord-006860-a3b8hyyr	536	32	)	)	-RRB-
cord-006860-a3b8hyyr	536	33	.	.	.
cord-006860-a3b8hyyr	537	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	537	2	,	,	,
cord-006860-a3b8hyyr	537	3	downregulation	downregulation	NN
cord-006860-a3b8hyyr	537	4	of	of	IN
cord-006860-a3b8hyyr	537	5	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	537	6	cell	cell	NN
cord-006860-a3b8hyyr	537	7	surface	surface	NN
cord-006860-a3b8hyyr	537	8	expressed	express	VBD
cord-006860-a3b8hyyr	537	9	TM	TM	NNP
cord-006860-a3b8hyyr	537	10	,	,	,
cord-006860-a3b8hyyr	537	11	for	for	IN
cord-006860-a3b8hyyr	537	12	example	example	NN
cord-006860-a3b8hyyr	537	13	,	,	,
cord-006860-a3b8hyyr	537	14	triggered	trigger	VBN
cord-006860-a3b8hyyr	537	15	by	by	IN
cord-006860-a3b8hyyr	537	16	an	an	DT
cord-006860-a3b8hyyr	537	17	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	537	18	stimulus	stimulus	NN
cord-006860-a3b8hyyr	537	19	,	,	,
cord-006860-a3b8hyyr	537	20	could	could	MD
cord-006860-a3b8hyyr	537	21	become	become	VB
cord-006860-a3b8hyyr	537	22	a	a	DT
cord-006860-a3b8hyyr	537	23	critical	critical	JJ
cord-006860-a3b8hyyr	537	24	factor	factor	NN
cord-006860-a3b8hyyr	537	25	in	in	IN
cord-006860-a3b8hyyr	537	26	effective	effective	JJ
cord-006860-a3b8hyyr	537	27	PC	pc	NN
cord-006860-a3b8hyyr	537	28	activation	activation	NN
cord-006860-a3b8hyyr	537	29	.	.	.
cord-006860-a3b8hyyr	538	1	In	in	IN
cord-006860-a3b8hyyr	538	2	order	order	NN
cord-006860-a3b8hyyr	538	3	to	to	TO
cord-006860-a3b8hyyr	538	4	develop	develop	VB
cord-006860-a3b8hyyr	538	5	a	a	DT
cord-006860-a3b8hyyr	538	6	recombinant	recombinant	NN
cord-006860-a3b8hyyr	538	7	(	(	-LRB-
cord-006860-a3b8hyyr	538	8	r	r	NN
cord-006860-a3b8hyyr	538	9	)	)	-RRB-
cord-006860-a3b8hyyr	538	10	PC	pc	NN
cord-006860-a3b8hyyr	538	11	mutant	mutant	NN
cord-006860-a3b8hyyr	538	12	which	which	WDT
cord-006860-a3b8hyyr	538	13	can	can	MD
cord-006860-a3b8hyyr	538	14	be	be	VB
cord-006860-a3b8hyyr	538	15	activated	activate	VBN
cord-006860-a3b8hyyr	538	16	independently	independently	RB
cord-006860-a3b8hyyr	538	17	of	of	IN
cord-006860-a3b8hyyr	538	18	the	the	DT
cord-006860-a3b8hyyr	538	19	TKM	TKM	NNP
cord-006860-a3b8hyyr	538	20	-	-	HYPH
cord-006860-a3b8hyyr	538	21	complex	complex	NNP
cord-006860-a3b8hyyr	538	22	,	,	,
cord-006860-a3b8hyyr	538	23	a	a	DT
cord-006860-a3b8hyyr	538	24	peptide	peptide	NN
cord-006860-a3b8hyyr	538	25	sequence	sequence	NN
cord-006860-a3b8hyyr	538	26	including	include	VBG
cord-006860-a3b8hyyr	538	27	P1	P1	NNP
cord-006860-a3b8hyyr	538	28	-	-	HYPH
cord-006860-a3b8hyyr	538	29	7	7	CD
cord-006860-a3b8hyyr	538	30	in	in	IN
cord-006860-a3b8hyyr	538	31	the	the	DT
cord-006860-a3b8hyyr	538	32	activation	activation	NN
cord-006860-a3b8hyyr	538	33	peptide	peptide	NN
cord-006860-a3b8hyyr	538	34	of	of	IN
cord-006860-a3b8hyyr	538	35	PC	PC	NNP
cord-006860-a3b8hyyr	538	36	was	be	VBD
cord-006860-a3b8hyyr	538	37	modified	modify	VBN
cord-006860-a3b8hyyr	538	38	to	to	TO
cord-006860-a3b8hyyr	538	39	be	be	VB
cord-006860-a3b8hyyr	538	40	identical	identical	JJ
cord-006860-a3b8hyyr	538	41	to	to	IN
cord-006860-a3b8hyyr	538	42	the	the	DT
cord-006860-a3b8hyyr	538	43	factor	factor	NN
cord-006860-a3b8hyyr	539	1	Xa	Xa	NNP
cord-006860-a3b8hyyr	539	2	(	(	-LRB-
cord-006860-a3b8hyyr	539	3	FXa)-cleavage	fxa)-cleavage	CD
cord-006860-a3b8hyyr	539	4	site	site	NN
cord-006860-a3b8hyyr	539	5	in	in	IN
cord-006860-a3b8hyyr	539	6	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	539	7	.	.	.
cord-006860-a3b8hyyr	540	1	The	the	DT
cord-006860-a3b8hyyr	540	2	mutant	mutant	NN
cord-006860-a3b8hyyr	540	3	was	be	VBD
cord-006860-a3b8hyyr	540	4	expressed	express	VBN
cord-006860-a3b8hyyr	540	5	in	in	IN
cord-006860-a3b8hyyr	540	6	HU	HU	NNP
cord-006860-a3b8hyyr	540	7	293	293	CD
cord-006860-a3b8hyyr	540	8	cells	cell	NNS
cord-006860-a3b8hyyr	540	9	,	,	,
cord-006860-a3b8hyyr	540	10	purified	purify	VBN
cord-006860-a3b8hyyr	540	11	and	and	CC
cord-006860-a3b8hyyr	540	12	its	-PRON-	PRP$
cord-006860-a3b8hyyr	540	13	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	540	14	properties	property	NNS
cord-006860-a3b8hyyr	540	15	characterized	characterize	VBN
cord-006860-a3b8hyyr	540	16	.	.	.
cord-006860-a3b8hyyr	541	1	Using	use	VBG
cord-006860-a3b8hyyr	541	2	purified	purify	VBN
cord-006860-a3b8hyyr	541	3	FXa	FXa	NNS
cord-006860-a3b8hyyr	541	4	the	the	DT
cord-006860-a3b8hyyr	541	5	mutant	mutant	NN
cord-006860-a3b8hyyr	541	6	showed	show	VBD
cord-006860-a3b8hyyr	541	7	activation	activation	NN
cord-006860-a3b8hyyr	541	8	rates	rate	NNS
cord-006860-a3b8hyyr	541	9	between	between	IN
cord-006860-a3b8hyyr	541	10	0.02	0.02	CD
cord-006860-a3b8hyyr	541	11	and	and	CC
cord-006860-a3b8hyyr	541	12	0.13	0.13	CD
cord-006860-a3b8hyyr	541	13	nMlmin	nMlmin	NNP
cord-006860-a3b8hyyr	541	14	at	at	IN
cord-006860-a3b8hyyr	541	15	PC	pc	NN
cord-006860-a3b8hyyr	541	16	concentrations	concentration	NNS
cord-006860-a3b8hyyr	541	17	between	between	IN
cord-006860-a3b8hyyr	541	18	97	97	CD
cord-006860-a3b8hyyr	541	19	and	and	CC
cord-006860-a3b8hyyr	541	20	770	770	CD
cord-006860-a3b8hyyr	541	21	nM	nm	NN
cord-006860-a3b8hyyr	541	22	,	,	,
cord-006860-a3b8hyyr	541	23	while	while	IN
cord-006860-a3b8hyyr	541	24	the	the	DT
cord-006860-a3b8hyyr	541	25	rPC	rPC	NNS
cord-006860-a3b8hyyr	541	26	wild	wild	JJ
cord-006860-a3b8hyyr	541	27	type	type	NN
cord-006860-a3b8hyyr	541	28	was	be	VBD
cord-006860-a3b8hyyr	541	29	insensitive	insensitive	JJ
cord-006860-a3b8hyyr	541	30	for	for	IN
cord-006860-a3b8hyyr	541	31	FXa	FXa	NNS
cord-006860-a3b8hyyr	541	32	activation	activation	NN
cord-006860-a3b8hyyr	541	33	.	.	.
cord-006860-a3b8hyyr	542	1	The	the	DT
cord-006860-a3b8hyyr	542	2	activation	activation	NN
cord-006860-a3b8hyyr	542	3	reaction	reaction	NN
cord-006860-a3b8hyyr	542	4	is	be	VBZ
cord-006860-a3b8hyyr	542	5	calcium	calcium	NN
cord-006860-a3b8hyyr	542	6	-	-	HYPH
cord-006860-a3b8hyyr	542	7	dependent	dependent	JJ
cord-006860-a3b8hyyr	542	8	reaching	reach	VBG
cord-006860-a3b8hyyr	542	9	maximal	maximal	JJ
cord-006860-a3b8hyyr	542	10	activation	activation	NN
cord-006860-a3b8hyyr	542	11	rates	rate	NNS
cord-006860-a3b8hyyr	542	12	at	at	IN
cord-006860-a3b8hyyr	542	13	a	a	DT
cord-006860-a3b8hyyr	542	14	calcium	calcium	NN
cord-006860-a3b8hyyr	542	15	concentration	concentration	NN
cord-006860-a3b8hyyr	542	16	of	of	IN
cord-006860-a3b8hyyr	542	17	3	3	CD
cord-006860-a3b8hyyr	542	18	mM	mm	CD
cord-006860-a3b8hyyr	542	19	and	and	CC
cord-006860-a3b8hyyr	542	20	was	be	VBD
cord-006860-a3b8hyyr	542	21	enhanced	enhance	VBN
cord-006860-a3b8hyyr	542	22	to	to	IN
cord-006860-a3b8hyyr	542	23	3.8-fold	3.8-fold	CD
cord-006860-a3b8hyyr	542	24	by	by	IN
cord-006860-a3b8hyyr	542	25	addition	addition	NN
cord-006860-a3b8hyyr	542	26	of	of	IN
cord-006860-a3b8hyyr	542	27	anionic	anionic	JJ
cord-006860-a3b8hyyr	542	28	phospholipids	phospholipid	NNS
cord-006860-a3b8hyyr	542	29	(	(	-LRB-
cord-006860-a3b8hyyr	542	30	PL	pl	NN
cord-006860-a3b8hyyr	542	31	)	)	-RRB-
cord-006860-a3b8hyyr	542	32	.	.	.
cord-006860-a3b8hyyr	543	1	In	in	IN
cord-006860-a3b8hyyr	543	2	contrast	contrast	NN
cord-006860-a3b8hyyr	543	3	to	to	IN
cord-006860-a3b8hyyr	543	4	the	the	DT
cord-006860-a3b8hyyr	543	5	wild	wild	JJ
cord-006860-a3b8hyyr	543	6	type	type	NN
cord-006860-a3b8hyyr	543	7	PC	pc	NN
cord-006860-a3b8hyyr	543	8	the	the	DT
cord-006860-a3b8hyyr	543	9	rPC	rPC	NNS
cord-006860-a3b8hyyr	543	10	mutant	mutant	NN
cord-006860-a3b8hyyr	543	11	was	be	VBD
cord-006860-a3b8hyyr	543	12	insensitive	insensitive	JJ
cord-006860-a3b8hyyr	543	13	for	for	IN
cord-006860-a3b8hyyr	543	14	activation	activation	NN
cord-006860-a3b8hyyr	543	15	by	by	IN
cord-006860-a3b8hyyr	543	16	the	the	DT
cord-006860-a3b8hyyr	543	17	T	T	NNP
cord-006860-a3b8hyyr	543	18	/	/	SYM
cord-006860-a3b8hyyr	543	19	I	I	NNP
cord-006860-a3b8hyyr	543	20	-	-	HYPH
cord-006860-a3b8hyyr	543	21	M	M	NNP
cord-006860-a3b8hyyr	543	22	complex	complex	NN
cord-006860-a3b8hyyr	543	23	.	.	.
cord-006860-a3b8hyyr	544	1	Addition	addition	NN
cord-006860-a3b8hyyr	544	2	of	of	IN
cord-006860-a3b8hyyr	544	3	the	the	DT
cord-006860-a3b8hyyr	544	4	mutant	mutant	JJ
cord-006860-a3b8hyyr	544	5	to	to	IN
cord-006860-a3b8hyyr	544	6	normal	normal	JJ
cord-006860-a3b8hyyr	544	7	human	human	JJ
cord-006860-a3b8hyyr	544	8	plasma	plasma	NN
cord-006860-a3b8hyyr	544	9	induces	induce	VBZ
cord-006860-a3b8hyyr	544	10	a	a	DT
cord-006860-a3b8hyyr	544	11	prolongation	prolongation	NN
cord-006860-a3b8hyyr	544	12	of	of	IN
cord-006860-a3b8hyyr	544	13	tissue	tissue	NN
cord-006860-a3b8hyyr	544	14	-	-	HYPH
cord-006860-a3b8hyyr	544	15	factor	factor	NN
cord-006860-a3b8hyyr	544	16	and	and	CC
cord-006860-a3b8hyyr	544	17	P	p	NN
cord-006860-a3b8hyyr	544	18	-	-	HYPH
cord-006860-a3b8hyyr	544	19	IT	it	NN
cord-006860-a3b8hyyr	544	20	-	-	HYPH
cord-006860-a3b8hyyr	544	21	based	base	VBN
cord-006860-a3b8hyyr	544	22	clotting	clotting	NN
cord-006860-a3b8hyyr	544	23	assays	assay	NNS
cord-006860-a3b8hyyr	544	24	.	.	.
cord-006860-a3b8hyyr	545	1	Using	use	VBG
cord-006860-a3b8hyyr	545	2	normal	normal	JJ
cord-006860-a3b8hyyr	545	3	human	human	JJ
cord-006860-a3b8hyyr	545	4	plasma	plasma	NN
cord-006860-a3b8hyyr	545	5	as	as	IN
cord-006860-a3b8hyyr	545	6	a	a	DT
cord-006860-a3b8hyyr	545	7	source	source	NN
cord-006860-a3b8hyyr	545	8	for	for	IN
cord-006860-a3b8hyyr	545	9	FXa	FXa	NNS
cord-006860-a3b8hyyr	545	10	the	the	DT
cord-006860-a3b8hyyr	545	11	the	the	DT
cord-006860-a3b8hyyr	545	12	activation	activation	NN
cord-006860-a3b8hyyr	545	13	rates	rate	NNS
cord-006860-a3b8hyyr	545	14	of	of	IN
cord-006860-a3b8hyyr	545	15	the	the	DT
cord-006860-a3b8hyyr	545	16	mutant	mutant	NN
cord-006860-a3b8hyyr	545	17	were	be	VBD
cord-006860-a3b8hyyr	545	18	found	find	VBN
cord-006860-a3b8hyyr	545	19	5-fold	5-fold	CD
cord-006860-a3b8hyyr	545	20	higher	high	JJR
cord-006860-a3b8hyyr	545	21	than	than	IN
cord-006860-a3b8hyyr	545	22	in	in	IN
cord-006860-a3b8hyyr	545	23	the	the	DT
cord-006860-a3b8hyyr	545	24	purified	purify	VBN
cord-006860-a3b8hyyr	545	25	system	system	NN
cord-006860-a3b8hyyr	545	26	if	if	IN
cord-006860-a3b8hyyr	545	27	tissue	tissue	NN
cord-006860-a3b8hyyr	545	28	factor	factor	NN
cord-006860-a3b8hyyr	545	29	was	be	VBD
cord-006860-a3b8hyyr	545	30	used	use	VBN
cord-006860-a3b8hyyr	545	31	to	to	TO
cord-006860-a3b8hyyr	545	32	generate	generate	VB
cord-006860-a3b8hyyr	545	33	FXa	FXa	NNS
cord-006860-a3b8hyyr	545	34	.	.	.
cord-006860-a3b8hyyr	546	1	In	in	IN
cord-006860-a3b8hyyr	546	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	546	3	,	,	,
cord-006860-a3b8hyyr	546	4	our	-PRON-	PRP$
cord-006860-a3b8hyyr	546	5	data	datum	NNS
cord-006860-a3b8hyyr	546	6	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	546	7	that	that	IN
cord-006860-a3b8hyyr	546	8	the	the	DT
cord-006860-a3b8hyyr	546	9	rPC	rPC	NNS
cord-006860-a3b8hyyr	546	10	mutant	mutant	NN
cord-006860-a3b8hyyr	546	11	is	be	VBZ
cord-006860-a3b8hyyr	546	12	effectively	effectively	RB
cord-006860-a3b8hyyr	546	13	activated	activate	VBN
cord-006860-a3b8hyyr	546	14	by	by	IN
cord-006860-a3b8hyyr	546	15	FXa	FXa	NNS
cord-006860-a3b8hyyr	546	16	in	in	IN
cord-006860-a3b8hyyr	546	17	a	a	DT
cord-006860-a3b8hyyr	546	18	purified	purify	VBN
cord-006860-a3b8hyyr	546	19	as	as	RB
cord-006860-a3b8hyyr	546	20	well	well	RB
cord-006860-a3b8hyyr	546	21	as	as	IN
cord-006860-a3b8hyyr	546	22	in	in	IN
cord-006860-a3b8hyyr	546	23	a	a	DT
cord-006860-a3b8hyyr	546	24	plasma	plasma	NN
cord-006860-a3b8hyyr	546	25	system	system	NN
cord-006860-a3b8hyyr	546	26	.	.	.
cord-006860-a3b8hyyr	547	1	Interestingly	interestingly	RB
cord-006860-a3b8hyyr	547	2	,	,	,
cord-006860-a3b8hyyr	547	3	the	the	DT
cord-006860-a3b8hyyr	547	4	activation	activation	NN
cord-006860-a3b8hyyr	547	5	rates	rate	NNS
cord-006860-a3b8hyyr	547	6	are	be	VBP
cord-006860-a3b8hyyr	547	7	enhanced	enhance	VBN
cord-006860-a3b8hyyr	547	8	in	in	IN
cord-006860-a3b8hyyr	547	9	the	the	DT
cord-006860-a3b8hyyr	547	10	presence	presence	NN
cord-006860-a3b8hyyr	547	11	of	of	IN
cord-006860-a3b8hyyr	547	12	PL	pl	NN
cord-006860-a3b8hyyr	547	13	and	and	CC
cord-006860-a3b8hyyr	547	14	normal	normal	JJ
cord-006860-a3b8hyyr	547	15	human	human	JJ
cord-006860-a3b8hyyr	547	16	plasma	plasma	NN
cord-006860-a3b8hyyr	547	17	.	.	.
cord-006860-a3b8hyyr	548	1	Fudher	Fudher	NNP
cord-006860-a3b8hyyr	548	2	studies	study	NNS
cord-006860-a3b8hyyr	548	3	should	should	MD
cord-006860-a3b8hyyr	548	4	clarify	clarify	VB
cord-006860-a3b8hyyr	548	5	the	the	DT
cord-006860-a3b8hyyr	548	6	potential	potential	JJ
cord-006860-a3b8hyyr	548	7	use	use	NN
cord-006860-a3b8hyyr	548	8	of	of	IN
cord-006860-a3b8hyyr	548	9	this	this	DT
cord-006860-a3b8hyyr	548	10	mutant	mutant	NN
cord-006860-a3b8hyyr	548	11	as	as	IN
cord-006860-a3b8hyyr	548	12	a	a	DT
cord-006860-a3b8hyyr	548	13	novel	novel	JJ
cord-006860-a3b8hyyr	548	14	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	548	15	.	.	.
cord-006860-a3b8hyyr	549	1	Thrombln	Thrombln	NNP
cord-006860-a3b8hyyr	549	2	plays	play	VBZ
cord-006860-a3b8hyyr	549	3	a	a	DT
cord-006860-a3b8hyyr	549	4	pivotal	pivotal	JJ
cord-006860-a3b8hyyr	549	5	role	role	NN
cord-006860-a3b8hyyr	549	6	in	in	IN
cord-006860-a3b8hyyr	549	7	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	549	8	events	event	NNS
cord-006860-a3b8hyyr	549	9	.	.	.
cord-006860-a3b8hyyr	550	1	The	the	DT
cord-006860-a3b8hyyr	550	2	time	time	NN
cord-006860-a3b8hyyr	550	3	course	course	NN
cord-006860-a3b8hyyr	550	4	of	of	IN
cord-006860-a3b8hyyr	550	5	thrombln	thrombln	JJ
cord-006860-a3b8hyyr	550	6	concentration	concentration	NN
cord-006860-a3b8hyyr	550	7	in	in	IN
cord-006860-a3b8hyyr	550	8	blood	blood	NN
cord-006860-a3b8hyyr	550	9	or	or	CC
cord-006860-a3b8hyyr	550	10	plasma	plasma	NN
cord-006860-a3b8hyyr	550	11	after	after	IN
cord-006860-a3b8hyyr	550	12	activation	activation	NN
cord-006860-a3b8hyyr	550	13	is	be	VBZ
cord-006860-a3b8hyyr	550	14	of	of	IN
cord-006860-a3b8hyyr	550	15	special	special	JJ
cord-006860-a3b8hyyr	550	16	Interest	interest	NN
cord-006860-a3b8hyyr	550	17	to	to	TO
cord-006860-a3b8hyyr	550	18	answer	answer	VB
cord-006860-a3b8hyyr	550	19	a	a	DT
cord-006860-a3b8hyyr	550	20	variety	variety	NN
cord-006860-a3b8hyyr	550	21	of	of	IN
cord-006860-a3b8hyyr	550	22	questions	question	NNS
cord-006860-a3b8hyyr	550	23	.	.	.
cord-006860-a3b8hyyr	551	1	With	with	IN
cord-006860-a3b8hyyr	551	2	a	a	DT
cord-006860-a3b8hyyr	551	3	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	551	4	assay	assay	NN
cord-006860-a3b8hyyr	551	5	developed	develop	VBN
cord-006860-a3b8hyyr	551	6	by	by	IN
cord-006860-a3b8hyyr	551	7	Hemker	Hemker	NNP
cord-006860-a3b8hyyr	551	8	et	et	NNP
cord-006860-a3b8hyyr	551	9	el	el	NNP
cord-006860-a3b8hyyr	551	10	.	.	.
cord-006860-a3b8hyyr	552	1	[	[	-LRB-
cord-006860-a3b8hyyr	552	2	Thromb	Thromb	NNP
cord-006860-a3b8hyyr	552	3	.	.	.
cord-006860-a3b8hyyr	553	1	Haemostas	Haemostas	NNP
cord-006860-a3b8hyyr	553	2	,	,	,
cord-006860-a3b8hyyr	553	3	70	70	CD
cord-006860-a3b8hyyr	553	4	,	,	,
cord-006860-a3b8hyyr	553	5	617	617	CD
cord-006860-a3b8hyyr	553	6	,	,	,
cord-006860-a3b8hyyr	553	7	1993	1993	CD
cord-006860-a3b8hyyr	553	8	]	]	-RRB-
cord-006860-a3b8hyyr	553	9	it	-PRON-	PRP
cord-006860-a3b8hyyr	553	10	became	become	VBD
cord-006860-a3b8hyyr	553	11	possible	possible	JJ
cord-006860-a3b8hyyr	553	12	to	to	TO
cord-006860-a3b8hyyr	553	13	measure	measure	VB
cord-006860-a3b8hyyr	553	14	the	the	DT
cord-006860-a3b8hyyr	553	15	generation	generation	NN
cord-006860-a3b8hyyr	553	16	of	of	IN
cord-006860-a3b8hyyr	553	17	thrombin	thrombin	NN
cord-006860-a3b8hyyr	553	18	in	in	IN
cord-006860-a3b8hyyr	553	19	activated	activate	VBN
cord-006860-a3b8hyyr	553	20	plasma	plasma	NN
cord-006860-a3b8hyyr	553	21	continuously	continuously	RB
cord-006860-a3b8hyyr	553	22	.	.	.
cord-006860-a3b8hyyr	554	1	Inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	554	2	of	of	IN
cord-006860-a3b8hyyr	554	3	clotting	clotting	NN
cord-006860-a3b8hyyr	554	4	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	554	5	which	which	WDT
cord-006860-a3b8hyyr	554	6	are	be	VBP
cord-006860-a3b8hyyr	554	7	to	to	TO
cord-006860-a3b8hyyr	554	8	be	be	VB
cord-006860-a3b8hyyr	554	9	developed	develop	VBN
cord-006860-a3b8hyyr	554	10	as	as	IN
cord-006860-a3b8hyyr	554	11	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	554	12	should	should	MD
cord-006860-a3b8hyyr	554	13	be	be	VB
cord-006860-a3b8hyyr	554	14	able	able	JJ
cord-006860-a3b8hyyr	554	15	to	to	TO
cord-006860-a3b8hyyr	554	16	inhibit	inhibit	VB
cord-006860-a3b8hyyr	554	17	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	554	18	generation	generation	NN
cord-006860-a3b8hyyr	554	19	or	or	CC
cord-006860-a3b8hyyr	554	20	to	to	TO
cord-006860-a3b8hyyr	554	21	Immediately	immediately	RB
cord-006860-a3b8hyyr	554	22	block	block	VB
cord-006860-a3b8hyyr	554	23	generated	generate	VBN
cord-006860-a3b8hyyr	554	24	thrombin	thrombin	NN
cord-006860-a3b8hyyr	554	25	.	.	.
cord-006860-a3b8hyyr	555	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	555	2	have	have	VBP
cord-006860-a3b8hyyr	555	3	used	use	VBN
cord-006860-a3b8hyyr	555	4	a	a	DT
cord-006860-a3b8hyyr	555	5	test	test	NN
cord-006860-a3b8hyyr	555	6	based	base	VBN
cord-006860-a3b8hyyr	555	7	on	on	IN
cord-006860-a3b8hyyr	555	8	Hemker	Hemker	NNP
cord-006860-a3b8hyyr	555	9	's	's	POS
cord-006860-a3b8hyyr	555	10	thrombin	thrombin	NN
cord-006860-a3b8hyyr	555	11	generation	generation	NN
cord-006860-a3b8hyyr	555	12	assay	assay	NN
cord-006860-a3b8hyyr	555	13	to	to	TO
cord-006860-a3b8hyyr	555	14	elucidate	elucidate	VB
cord-006860-a3b8hyyr	555	15	which	which	WDT
cord-006860-a3b8hyyr	555	16	potency	potency	NN
cord-006860-a3b8hyyr	555	17	and	and	CC
cord-006860-a3b8hyyr	555	18	specificity	specificity	NN
cord-006860-a3b8hyyr	555	19	an	an	DT
cord-006860-a3b8hyyr	555	20	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	555	21	of	of	IN
cord-006860-a3b8hyyr	555	22	factor	factor	NN
cord-006860-a3b8hyyr	555	23	Xa	Xa	NNP
cord-006860-a3b8hyyr	555	24	needs	need	VBZ
cord-006860-a3b8hyyr	555	25	to	to	TO
cord-006860-a3b8hyyr	555	26	efficiently	efficiently	RB
cord-006860-a3b8hyyr	555	27	block	block	VB
cord-006860-a3b8hyyr	555	28	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	555	29	generation	generation	NN
cord-006860-a3b8hyyr	555	30	in	in	IN
cord-006860-a3b8hyyr	555	31	human	human	JJ
cord-006860-a3b8hyyr	555	32	plasma	plasma	NN
cord-006860-a3b8hyyr	555	33	.	.	.
cord-006860-a3b8hyyr	556	1	Thrombin	Thrombin	NNP
cord-006860-a3b8hyyr	556	2	generation	generation	NN
cord-006860-a3b8hyyr	556	3	after	after	IN
cord-006860-a3b8hyyr	556	4	extrinsic	extrinsic	JJ
cord-006860-a3b8hyyr	556	5	(	(	-LRB-
cord-006860-a3b8hyyr	556	6	tissue	tissue	NN
cord-006860-a3b8hyyr	556	7	factor	factor	NN
cord-006860-a3b8hyyr	556	8	)	)	-RRB-
cord-006860-a3b8hyyr	556	9	or	or	CC
cord-006860-a3b8hyyr	556	10	intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	556	11	(	(	-LRB-
cord-006860-a3b8hyyr	556	12	ellagic	ellagic	JJ
cord-006860-a3b8hyyr	556	13	acid	acid	NN
cord-006860-a3b8hyyr	556	14	)	)	-RRB-
cord-006860-a3b8hyyr	556	15	activation	activation	NN
cord-006860-a3b8hyyr	556	16	was	be	VBD
cord-006860-a3b8hyyr	556	17	followed	follow	VBN
cord-006860-a3b8hyyr	556	18	using	use	VBG
cord-006860-a3b8hyyr	556	19	the	the	DT
cord-006860-a3b8hyyr	556	20	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	556	21	substrate	substrate	NN
cord-006860-a3b8hyyr	556	22	H-~Ala	H-~Ala	NNP
cord-006860-a3b8hyyr	556	23	-	-	HYPH
cord-006860-a3b8hyyr	556	24	Gly	Gly	NNP
cord-006860-a3b8hyyr	556	25	-	-	HYPH
cord-006860-a3b8hyyr	556	26	Arg	arg	NN
cord-006860-a3b8hyyr	556	27	-	-	HYPH
cord-006860-a3b8hyyr	556	28	pNA	pNA	NNP
cord-006860-a3b8hyyr	556	29	(	(	-LRB-
cord-006860-a3b8hyyr	556	30	Pentapharm	Pentapharm	NNP
cord-006860-a3b8hyyr	556	31	Ltd.	Ltd.	NNP
cord-006860-a3b8hyyr	556	32	)	)	-RRB-
cord-006860-a3b8hyyr	556	33	.	.	.
cord-006860-a3b8hyyr	557	1	A	a	DT
cord-006860-a3b8hyyr	557	2	series	series	NN
cord-006860-a3b8hyyr	557	3	of	of	IN
cord-006860-a3b8hyyr	557	4	synthetic	synthetic	JJ
cord-006860-a3b8hyyr	557	5	low	low	JJ
cord-006860-a3b8hyyr	557	6	molecular	molecular	JJ
cord-006860-a3b8hyyr	557	7	weight	weight	NN
cord-006860-a3b8hyyr	557	8	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	557	9	as	as	RB
cord-006860-a3b8hyyr	557	10	well	well	RB
cord-006860-a3b8hyyr	557	11	as	as	IN
cord-006860-a3b8hyyr	557	12	naturally	naturally	RB
cord-006860-a3b8hyyr	557	13	occurring	occur	VBG
cord-006860-a3b8hyyr	557	14	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	557	15	of	of	IN
cord-006860-a3b8hyyr	557	16	factor	factor	NN
cord-006860-a3b8hyyr	557	17	Xa	Xa	NNP
cord-006860-a3b8hyyr	557	18	with	with	IN
cord-006860-a3b8hyyr	557	19	different	different	JJ
cord-006860-a3b8hyyr	557	20	potency	potency	NN
cord-006860-a3b8hyyr	557	21	were	be	VBD
cord-006860-a3b8hyyr	557	22	investigated	investigate	VBN
cord-006860-a3b8hyyr	557	23	.	.	.
cord-006860-a3b8hyyr	558	1	Because	because	IN
cord-006860-a3b8hyyr	558	2	of	of	IN
cord-006860-a3b8hyyr	558	3	the	the	DT
cord-006860-a3b8hyyr	558	4	inhibition	inhibition	NN
cord-006860-a3b8hyyr	558	5	of	of	IN
cord-006860-a3b8hyyr	558	6	activated	activate	VBN
cord-006860-a3b8hyyr	558	7	factor	factor	NN
cord-006860-a3b8hyyr	558	8	X	X	VBZ
cord-006860-a3b8hyyr	558	9	the	the	DT
cord-006860-a3b8hyyr	558	10	generation	generation	NN
cord-006860-a3b8hyyr	558	11	of	of	IN
cord-006860-a3b8hyyr	558	12	thrombin	thrombin	NN
cord-006860-a3b8hyyr	558	13	in	in	IN
cord-006860-a3b8hyyr	558	14	plasma	plasma	NN
cord-006860-a3b8hyyr	558	15	Is	be	VBZ
cord-006860-a3b8hyyr	558	16	delayed	delay	VBN
cord-006860-a3b8hyyr	558	17	and	and	CC
cord-006860-a3b8hyyr	558	18	the	the	DT
cord-006860-a3b8hyyr	558	19	amount	amount	NN
cord-006860-a3b8hyyr	558	20	of	of	IN
cord-006860-a3b8hyyr	558	21	the	the	DT
cord-006860-a3b8hyyr	558	22	generated	generate	VBN
cord-006860-a3b8hyyr	558	23	thrombin	thrombin	NN
cord-006860-a3b8hyyr	558	24	is	be	VBZ
cord-006860-a3b8hyyr	558	25	reduced	reduce	VBN
cord-006860-a3b8hyyr	558	26	.	.	.
cord-006860-a3b8hyyr	559	1	The	the	DT
cord-006860-a3b8hyyr	559	2	concentrations	concentration	NNS
cord-006860-a3b8hyyr	559	3	which	which	WDT
cord-006860-a3b8hyyr	559	4	cause	cause	VBP
cord-006860-a3b8hyyr	559	5	a	a	DT
cord-006860-a3b8hyyr	559	6	50	50	CD
cord-006860-a3b8hyyr	559	7	%	%	NN
cord-006860-a3b8hyyr	559	8	inhibition	inhibition	NN
cord-006860-a3b8hyyr	559	9	of	of	IN
cord-006860-a3b8hyyr	559	10	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	559	11	generation	generation	NN
cord-006860-a3b8hyyr	559	12	(	(	-LRB-
cord-006860-a3b8hyyr	559	13	ICso	icso	CD
cord-006860-a3b8hyyr	559	14	)	)	-RRB-
cord-006860-a3b8hyyr	559	15	correlate	correlate	VB
cord-006860-a3b8hyyr	559	16	with	with	IN
cord-006860-a3b8hyyr	559	17	the	the	DT
cord-006860-a3b8hyyr	559	18	K~	K~	NNP
cord-006860-a3b8hyyr	559	19	values	value	NNS
cord-006860-a3b8hyyr	559	20	of	of	IN
cord-006860-a3b8hyyr	559	21	the	the	DT
cord-006860-a3b8hyyr	559	22	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	559	23	.	.	.
cord-006860-a3b8hyyr	560	1	Low	low	JJ
cord-006860-a3b8hyyr	560	2	molecular	molecular	JJ
cord-006860-a3b8hyyr	560	3	weight	weight	NN
cord-006860-a3b8hyyr	560	4	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	560	5	with	with	IN
cord-006860-a3b8hyyr	560	6	K~	k~	JJ
cord-006860-a3b8hyyr	560	7	values	value	NNS
cord-006860-a3b8hyyr	560	8	of	of	IN
cord-006860-a3b8hyyr	560	9	about	about	RB
cord-006860-a3b8hyyr	560	10	20	20	CD
cord-006860-a3b8hyyr	560	11	nmol/	nmol/	CD
cord-006860-a3b8hyyr	561	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	561	2	inhibit	inhibit	VBP
cord-006860-a3b8hyyr	561	3	the	the	DT
cord-006860-a3b8hyyr	561	4	generation	generation	NN
cord-006860-a3b8hyyr	561	5	of	of	IN
cord-006860-a3b8hyyr	561	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	561	7	after	after	IN
cord-006860-a3b8hyyr	561	8	extrinsic	extrinsic	JJ
cord-006860-a3b8hyyr	561	9	activation	activation	NN
cord-006860-a3b8hyyr	561	10	with	with	IN
cord-006860-a3b8hyyr	561	11	ICso	ICso	NNP
cord-006860-a3b8hyyr	561	12	in	in	IN
cord-006860-a3b8hyyr	561	13	micromolar	micromolar	JJ
cord-006860-a3b8hyyr	561	14	range	range	NN
cord-006860-a3b8hyyr	561	15	.	.	.
cord-006860-a3b8hyyr	562	1	After	after	IN
cord-006860-a3b8hyyr	562	2	activation	activation	NN
cord-006860-a3b8hyyr	562	3	of	of	IN
cord-006860-a3b8hyyr	562	4	the	the	DT
cord-006860-a3b8hyyr	562	5	intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	562	6	pathway	pathway	NN
cord-006860-a3b8hyyr	562	7	tenfold	tenfold	IN
cord-006860-a3b8hyyr	562	8	lower	low	JJR
cord-006860-a3b8hyyr	562	9	concentrations	concentration	NNS
cord-006860-a3b8hyyr	562	10	are	be	VBP
cord-006860-a3b8hyyr	562	11	effective	effective	JJ
cord-006860-a3b8hyyr	562	12	.	.	.
cord-006860-a3b8hyyr	563	1	The	the	DT
cord-006860-a3b8hyyr	563	2	strongest	strong	JJS
cord-006860-a3b8hyyr	563	3	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	563	4	activity	activity	NN
cord-006860-a3b8hyyr	563	5	after	after	IN
cord-006860-a3b8hyyr	563	6	extrinsic	extrinsic	JJ
cord-006860-a3b8hyyr	563	7	as	as	RB
cord-006860-a3b8hyyr	563	8	well	well	RB
cord-006860-a3b8hyyr	563	9	as	as	IN
cord-006860-a3b8hyyr	563	10	intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	563	11	activation	activation	NN
cord-006860-a3b8hyyr	563	12	is	be	VBZ
cord-006860-a3b8hyyr	563	13	shown	show	VBN
cord-006860-a3b8hyyr	563	14	by	by	IN
cord-006860-a3b8hyyr	563	15	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	563	16	tick	tick	NN
cord-006860-a3b8hyyr	563	17	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	563	18	peptide	peptide	NN
cord-006860-a3b8hyyr	563	19	(	(	-LRB-
cord-006860-a3b8hyyr	563	20	r	r	NN
cord-006860-a3b8hyyr	563	21	-	-	HYPH
cord-006860-a3b8hyyr	563	22	TAP	tap	NN
cord-006860-a3b8hyyr	563	23	)	)	-RRB-
cord-006860-a3b8hyyr	563	24	with	with	IN
cord-006860-a3b8hyyr	563	25	IC~	IC~	NNP
cord-006860-a3b8hyyr	564	1	o	o	NN
cord-006860-a3b8hyyr	564	2	of	of	IN
cord-006860-a3b8hyyr	564	3	0.049	0.049	CD
cord-006860-a3b8hyyr	564	4	pmol	pmol	NN
cord-006860-a3b8hyyr	564	5	/	/	,
cord-006860-a3b8hyyr	564	6	I	-PRON-	PRP
cord-006860-a3b8hyyr	564	7	(	(	-LRB-
cord-006860-a3b8hyyr	564	8	axtdqsic	axtdqsic	NNP
cord-006860-a3b8hyyr	564	9	)	)	-RRB-
cord-006860-a3b8hyyr	564	10	and	and	CC
cord-006860-a3b8hyyr	564	11	0.037	0.037	CD
cord-006860-a3b8hyyr	564	12	pmo	pmo	NNP
cord-006860-a3b8hyyr	564	13	/	/	SYM
cord-006860-a3b8hyyr	564	14	I	I	NNP
cord-006860-a3b8hyyr	564	15	(	(	-LRB-
cord-006860-a3b8hyyr	564	16	intdnsic	intdnsic	NNP
cord-006860-a3b8hyyr	564	17	)	)	-RRB-
cord-006860-a3b8hyyr	564	18	.	.	.
cord-006860-a3b8hyyr	565	1	In	in	IN
cord-006860-a3b8hyyr	565	2	the	the	DT
cord-006860-a3b8hyyr	565	3	compadson	compadson	NN
cord-006860-a3b8hyyr	565	4	of	of	IN
cord-006860-a3b8hyyr	565	5	synthetic	synthetic	JJ
cord-006860-a3b8hyyr	565	6	low	low	JJ
cord-006860-a3b8hyyr	565	7	molecular	molecular	JJ
cord-006860-a3b8hyyr	565	8	weight	weight	NN
cord-006860-a3b8hyyr	565	9	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	565	10	of	of	IN
cord-006860-a3b8hyyr	565	11	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	565	12	end	end	NN
cord-006860-a3b8hyyr	565	13	factor	factor	NN
cord-006860-a3b8hyyr	565	14	Xa	Xa	NNP
cord-006860-a3b8hyyr	565	15	which	which	WDT
cord-006860-a3b8hyyr	565	16	have	have	VBP
cord-006860-a3b8hyyr	565	17	similar	similar	JJ
cord-006860-a3b8hyyr	565	18	K=	K=	NNP
cord-006860-a3b8hyyr	565	19	values	value	NNS
cord-006860-a3b8hyyr	565	20	for	for	IN
cord-006860-a3b8hyyr	565	21	the	the	DT
cord-006860-a3b8hyyr	565	22	inhibition	inhibition	NN
cord-006860-a3b8hyyr	565	23	of	of	IN
cord-006860-a3b8hyyr	565	24	the	the	DT
cord-006860-a3b8hyyr	565	25	respective	respective	JJ
cord-006860-a3b8hyyr	565	26	enzyme	enzyme	NN
cord-006860-a3b8hyyr	565	27	(	(	-LRB-
cord-006860-a3b8hyyr	565	28	lowest	low	JJS
cord-006860-a3b8hyyr	565	29	I<1	I<1	NNP
cord-006860-a3b8hyyr	565	30	20	20	CD
cord-006860-a3b8hyyr	565	31	nmol	nmol	JJ
cord-006860-a3b8hyyr	565	32	/	/	,
cord-006860-a3b8hyyr	565	33	I	i	NN
cord-006860-a3b8hyyr	565	34	)	)	-RRB-
cord-006860-a3b8hyyr	565	35	,	,	,
cord-006860-a3b8hyyr	565	36	factor	factor	NN
cord-006860-a3b8hyyr	565	37	Xa	Xa	NNP
cord-006860-a3b8hyyr	565	38	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	565	39	are	be	VBP
cord-006860-a3b8hyyr	565	40	less	less	RBR
cord-006860-a3b8hyyr	565	41	effective	effective	JJ
cord-006860-a3b8hyyr	565	42	tn	tn	NNP
cord-006860-a3b8hyyr	565	43	the	the	DT
cord-006860-a3b8hyyr	565	44	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	565	45	generation	generation	NN
cord-006860-a3b8hyyr	565	46	assay	assay	NN
cord-006860-a3b8hyyr	565	47	.	.	.
cord-006860-a3b8hyyr	566	1	In	in	IN
cord-006860-a3b8hyyr	566	2	contrast	contrast	NN
cord-006860-a3b8hyyr	566	3	,	,	,
cord-006860-a3b8hyyr	566	4	the	the	DT
cord-006860-a3b8hyyr	566	5	highly	highly	RB
cord-006860-a3b8hyyr	566	6	potent	potent	JJ
cord-006860-a3b8hyyr	566	7	Xa	Xa	NNP
cord-006860-a3b8hyyr	566	8	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	566	9	r	r	NN
cord-006860-a3b8hyyr	566	10	-	-	:
cord-006860-a3b8hyyr	566	11	TAP	tap	NN
cord-006860-a3b8hyyr	566	12	shows	show	VBZ
cord-006860-a3b8hyyr	566	13	a	a	DT
cord-006860-a3b8hyyr	566	14	stronger	strong	JJR
cord-006860-a3b8hyyr	566	15	inhibition	inhibition	NN
cord-006860-a3b8hyyr	566	16	of	of	IN
cord-006860-a3b8hyyr	566	17	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	566	18	generation	generation	NN
cord-006860-a3b8hyyr	566	19	than	than	IN
cord-006860-a3b8hyyr	566	20	the	the	DT
cord-006860-a3b8hyyr	566	21	tight	tight	JJ
cord-006860-a3b8hyyr	566	22	binding	binding	JJ
cord-006860-a3b8hyyr	566	23	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	566	24	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	566	25	hirudin	hirudin	NN
cord-006860-a3b8hyyr	566	26	.	.	.
cord-006860-a3b8hyyr	567	1	Background	background	NN
cord-006860-a3b8hyyr	567	2	:	:	:
cord-006860-a3b8hyyr	568	1	Resistance	resistance	NN
cord-006860-a3b8hyyr	568	2	to	to	IN
cord-006860-a3b8hyyr	568	3	degradation	degradation	NN
cord-006860-a3b8hyyr	568	4	of	of	IN
cord-006860-a3b8hyyr	568	5	coagulation	coagulation	NN
cord-006860-a3b8hyyr	568	6	factor	factor	NN
cord-006860-a3b8hyyr	568	7	V	v	NN
cord-006860-a3b8hyyr	568	8	by	by	IN
cord-006860-a3b8hyyr	568	9	activated	activate	VBN
cord-006860-a3b8hyyr	568	10	protein	protein	NN
cord-006860-a3b8hyyr	568	11	C	C	NNP
cord-006860-a3b8hyyr	568	12	is	be	VBZ
cord-006860-a3b8hyyr	568	13	associated	associate	VBN
cord-006860-a3b8hyyr	568	14	with	with	IN
cord-006860-a3b8hyyr	568	15	a	a	DT
cord-006860-a3b8hyyr	568	16	point	point	NN
cord-006860-a3b8hyyr	568	17	mutation	mutation	NN
cord-006860-a3b8hyyr	568	18	in	in	IN
cord-006860-a3b8hyyr	568	19	which	which	WDT
cord-006860-a3b8hyyr	568	20	adenine	adenine	NN
cord-006860-a3b8hyyr	568	21	is	be	VBZ
cord-006860-a3b8hyyr	568	22	substituted	substitute	VBN
cord-006860-a3b8hyyr	568	23	for	for	IN
cord-006860-a3b8hyyr	568	24	guanine	guanine	NN
cord-006860-a3b8hyyr	568	25	at	at	IN
cord-006860-a3b8hyyr	568	26	nucleotide	nucleotide	JJ
cord-006860-a3b8hyyr	568	27	1691	1691	CD
cord-006860-a3b8hyyr	568	28	in	in	IN
cord-006860-a3b8hyyr	568	29	the	the	DT
cord-006860-a3b8hyyr	568	30	gene	gene	NN
cord-006860-a3b8hyyr	568	31	coding	code	VBG
cord-006860-a3b8hyyr	568	32	for	for	IN
cord-006860-a3b8hyyr	568	33	factor	factor	NN
cord-006860-a3b8hyyr	568	34	V.	V.	NNP
cord-006860-a3b8hyyr	569	1	To	to	IN
cord-006860-a3b8hyyr	569	2	date	date	NN
cord-006860-a3b8hyyr	569	3	this	this	DT
cord-006860-a3b8hyyr	569	4	specifc	specifc	JJ
cord-006860-a3b8hyyr	569	5	mutation	mutation	NN
cord-006860-a3b8hyyr	569	6	appears	appear	VBZ
cord-006860-a3b8hyyr	569	7	to	to	TO
cord-006860-a3b8hyyr	569	8	be	be	VB
cord-006860-a3b8hyyr	569	9	the	the	DT
cord-006860-a3b8hyyr	569	10	most	most	RBS
cord-006860-a3b8hyyr	569	11	common	common	JJ
cord-006860-a3b8hyyr	569	12	inherited	inherit	VBN
cord-006860-a3b8hyyr	569	13	abnormality	abnormality	NN
cord-006860-a3b8hyyr	569	14	which	which	WDT
cord-006860-a3b8hyyr	569	15	predisposes	predispose	VBZ
cord-006860-a3b8hyyr	569	16	patients	patient	NNS
cord-006860-a3b8hyyr	569	17	to	to	IN
cord-006860-a3b8hyyr	569	18	venous	venous	JJ
cord-006860-a3b8hyyr	569	19	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	569	20	.	.	.
cord-006860-a3b8hyyr	570	1	For	for	IN
cord-006860-a3b8hyyr	570	2	this	this	DT
cord-006860-a3b8hyyr	570	3	reason	reason	NN
cord-006860-a3b8hyyr	570	4	a	a	DT
cord-006860-a3b8hyyr	570	5	reliable	reliable	JJ
cord-006860-a3b8hyyr	570	6	,	,	,
cord-006860-a3b8hyyr	570	7	fast	fast	JJ
cord-006860-a3b8hyyr	570	8	and	and	CC
cord-006860-a3b8hyyr	570	9	automatable	automatable	JJ
cord-006860-a3b8hyyr	570	10	system	system	NN
cord-006860-a3b8hyyr	570	11	for	for	IN
cord-006860-a3b8hyyr	570	12	the	the	DT
cord-006860-a3b8hyyr	570	13	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	570	14	of	of	IN
cord-006860-a3b8hyyr	570	15	the	the	DT
cord-006860-a3b8hyyr	570	16	described	describe	VBN
cord-006860-a3b8hyyr	570	17	point	point	NN
cord-006860-a3b8hyyr	570	18	mutation	mutation	NN
cord-006860-a3b8hyyr	570	19	is	be	VBZ
cord-006860-a3b8hyyr	570	20	required	require	VBN
cord-006860-a3b8hyyr	570	21	.	.	.
cord-006860-a3b8hyyr	571	1	The	the	DT
cord-006860-a3b8hyyr	571	2	conventional	conventional	JJ
cord-006860-a3b8hyyr	571	3	methods	method	NNS
cord-006860-a3b8hyyr	571	4	used	use	VBN
cord-006860-a3b8hyyr	571	5	to	to	TO
cord-006860-a3b8hyyr	571	6	identify	identify	VB
cord-006860-a3b8hyyr	571	7	the	the	DT
cord-006860-a3b8hyyr	571	8	mutation	mutation	NN
cord-006860-a3b8hyyr	571	9	are	be	VBP
cord-006860-a3b8hyyr	571	10	based	base	VBN
cord-006860-a3b8hyyr	571	11	on	on	IN
cord-006860-a3b8hyyr	571	12	allele	allele	NN
cord-006860-a3b8hyyr	571	13	-	-	HYPH
cord-006860-a3b8hyyr	571	14	specific	specific	JJ
cord-006860-a3b8hyyr	571	15	restriction	restriction	NN
cord-006860-a3b8hyyr	571	16	enzyme	enzyme	NN
cord-006860-a3b8hyyr	571	17	site	site	NN
cord-006860-a3b8hyyr	571	18	analysis	analysis	NN
cord-006860-a3b8hyyr	571	19	or	or	CC
cord-006860-a3b8hyyr	571	20	direct	direct	JJ
cord-006860-a3b8hyyr	571	21	sequencing	sequencing	NN
cord-006860-a3b8hyyr	571	22	.	.	.
cord-006860-a3b8hyyr	572	1	These	these	DT
cord-006860-a3b8hyyr	572	2	methods	method	NNS
cord-006860-a3b8hyyr	572	3	have	have	VBP
cord-006860-a3b8hyyr	572	4	disadvantages	disadvantage	NNS
cord-006860-a3b8hyyr	572	5	for	for	IN
cord-006860-a3b8hyyr	572	6	a	a	DT
cord-006860-a3b8hyyr	572	7	large	large	JJ
cord-006860-a3b8hyyr	572	8	scale	scale	NN
cord-006860-a3b8hyyr	572	9	DNA	dna	NN
cord-006860-a3b8hyyr	572	10	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	572	11	,	,	,
cord-006860-a3b8hyyr	572	12	which	which	WDT
cord-006860-a3b8hyyr	572	13	include	include	VBP
cord-006860-a3b8hyyr	572	14	the	the	DT
cord-006860-a3b8hyyr	572	15	need	need	NN
cord-006860-a3b8hyyr	572	16	for	for	IN
cord-006860-a3b8hyyr	572	17	electrophoresis	electrophoresis	NN
cord-006860-a3b8hyyr	572	18	or	or	CC
cord-006860-a3b8hyyr	572	19	a	a	DT
cord-006860-a3b8hyyr	572	20	high	high	JJ
cord-006860-a3b8hyyr	572	21	cost	cost	NN
cord-006860-a3b8hyyr	572	22	and	and	CC
cord-006860-a3b8hyyr	572	23	time	time	NN
cord-006860-a3b8hyyr	572	24	consumption	consumption	NN
cord-006860-a3b8hyyr	572	25	.	.	.
cord-006860-a3b8hyyr	573	1	Methods	method	NNS
cord-006860-a3b8hyyr	573	2	:	:	:
cord-006860-a3b8hyyr	573	3	An	an	DT
cord-006860-a3b8hyyr	573	4	alternative	alternative	JJ
cord-006860-a3b8hyyr	573	5	strategy	strategy	NN
cord-006860-a3b8hyyr	573	6	of	of	IN
cord-006860-a3b8hyyr	573	7	DNA	dna	NN
cord-006860-a3b8hyyr	573	8	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	573	9	,	,	,
cord-006860-a3b8hyyr	573	10	the	the	DT
cord-006860-a3b8hyyr	573	11	allele	allele	NN
cord-006860-a3b8hyyr	573	12	-	-	HYPH
cord-006860-a3b8hyyr	573	13	specific	specific	JJ
cord-006860-a3b8hyyr	573	14	oligonucleotide	oligonucleotide	JJ
cord-006860-a3b8hyyr	573	15	ligation	ligation	NN
cord-006860-a3b8hyyr	573	16	assay	assay	NN
cord-006860-a3b8hyyr	573	17	,	,	,
cord-006860-a3b8hyyr	573	18	was	be	VBD
cord-006860-a3b8hyyr	573	19	adapted	adapt	VBN
cord-006860-a3b8hyyr	573	20	for	for	IN
cord-006860-a3b8hyyr	573	21	the	the	DT
cord-006860-a3b8hyyr	573	22	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	573	23	of	of	IN
cord-006860-a3b8hyyr	573	24	tile	tile	NN
cord-006860-a3b8hyyr	573	25	point	point	NN
cord-006860-a3b8hyyr	573	26	mutation	mutation	NN
cord-006860-a3b8hyyr	573	27	of	of	IN
cord-006860-a3b8hyyr	573	28	factor	factor	NN
cord-006860-a3b8hyyr	573	29	V.	V.	NNP
cord-006860-a3b8hyyr	574	1	Following	follow	VBG
cord-006860-a3b8hyyr	574	2	PCR	pcr	NN
cord-006860-a3b8hyyr	574	3	amplification	amplification	NN
cord-006860-a3b8hyyr	574	4	of	of	IN
cord-006860-a3b8hyyr	574	5	the	the	DT
cord-006860-a3b8hyyr	574	6	target	target	NN
cord-006860-a3b8hyyr	574	7	DNA	dna	NN
cord-006860-a3b8hyyr	574	8	,	,	,
cord-006860-a3b8hyyr	574	9	tile	tile	NN
cord-006860-a3b8hyyr	574	10	procedure	procedure	NN
cord-006860-a3b8hyyr	574	11	was	be	VBD
cord-006860-a3b8hyyr	574	12	performed	perform	VBN
cord-006860-a3b8hyyr	574	13	completely	completely	RB
cord-006860-a3b8hyyr	574	14	automatically	automatically	RB
cord-006860-a3b8hyyr	574	15	on	on	IN
cord-006860-a3b8hyyr	574	16	a	a	DT
cord-006860-a3b8hyyr	574	17	robotic	robotic	JJ
cord-006860-a3b8hyyr	574	18	workstation	workstation	NN
cord-006860-a3b8hyyr	574	19	with	with	IN
cord-006860-a3b8hyyr	574	20	an	an	DT
cord-006860-a3b8hyyr	574	21	integrated	integrate	VBN
cord-006860-a3b8hyyr	574	22	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	574	23	reader	reader	NN
cord-006860-a3b8hyyr	574	24	using	use	VBG
cord-006860-a3b8hyyr	574	25	a	a	DT
cord-006860-a3b8hyyr	574	26	96-well	96-well	CD
cord-006860-a3b8hyyr	574	27	microtiter	microtiter	NN
cord-006860-a3b8hyyr	574	28	plate	plate	NN
cord-006860-a3b8hyyr	574	29	.	.	.
cord-006860-a3b8hyyr	575	1	Allelespecific	allelespecific	JJ
cord-006860-a3b8hyyr	575	2	restriction	restriction	NN
cord-006860-a3b8hyyr	575	3	enzyme	enzyme	NN
cord-006860-a3b8hyyr	575	4	site	site	NN
cord-006860-a3b8hyyr	575	5	analysis	analysis	NN
cord-006860-a3b8hyyr	575	6	was	be	VBD
cord-006860-a3b8hyyr	575	7	performed	perform	VBN
cord-006860-a3b8hyyr	575	8	to	to	TO
cord-006860-a3b8hyyr	575	9	confirm	confirm	VB
cord-006860-a3b8hyyr	575	10	the	the	DT
cord-006860-a3b8hyyr	575	11	genotypes	genotype	NNS
cord-006860-a3b8hyyr	575	12	.	.	.
cord-006860-a3b8hyyr	576	1	Results	result	NNS
cord-006860-a3b8hyyr	576	2	:	:	:
cord-006860-a3b8hyyr	577	1	In	in	IN
cord-006860-a3b8hyyr	577	2	10	10	CD
cord-006860-a3b8hyyr	577	3	patients	patient	NNS
cord-006860-a3b8hyyr	577	4	with	with	IN
cord-006860-a3b8hyyr	577	5	the	the	DT
cord-006860-a3b8hyyr	577	6	mutation	mutation	NN
cord-006860-a3b8hyyr	577	7	and	and	CC
cord-006860-a3b8hyyr	577	8	in	in	IN
cord-006860-a3b8hyyr	577	9	20	20	CD
cord-006860-a3b8hyyr	577	10	individuals	individual	NNS
cord-006860-a3b8hyyr	577	11	without	without	IN
cord-006860-a3b8hyyr	577	12	the	the	DT
cord-006860-a3b8hyyr	577	13	mutation	mutation	NN
cord-006860-a3b8hyyr	577	14	the	the	DT
cord-006860-a3b8hyyr	577	15	genotypes	genotype	NNS
cord-006860-a3b8hyyr	577	16	determined	determine	VBN
cord-006860-a3b8hyyr	577	17	with	with	IN
cord-006860-a3b8hyyr	577	18	the	the	DT
cord-006860-a3b8hyyr	577	19	conventional	conventional	JJ
cord-006860-a3b8hyyr	577	20	allele	allele	NN
cord-006860-a3b8hyyr	577	21	-	-	HYPH
cord-006860-a3b8hyyr	577	22	specific	specific	JJ
cord-006860-a3b8hyyr	577	23	restriction	restriction	NN
cord-006860-a3b8hyyr	577	24	enzyme	enzyme	NN
cord-006860-a3b8hyyr	577	25	site	site	NN
cord-006860-a3b8hyyr	577	26	analysis	analysis	NN
cord-006860-a3b8hyyr	577	27	were	be	VBD
cord-006860-a3b8hyyr	577	28	in	in	IN
cord-006860-a3b8hyyr	577	29	100	100	CD
cord-006860-a3b8hyyr	577	30	%	%	NN
cord-006860-a3b8hyyr	577	31	concordance	concordance	NN
cord-006860-a3b8hyyr	577	32	with	with	IN
cord-006860-a3b8hyyr	577	33	the	the	DT
cord-006860-a3b8hyyr	577	34	ELISAbased	elisabased	JJ
cord-006860-a3b8hyyr	577	35	oligonucleotide	oligonucleotide	JJ
cord-006860-a3b8hyyr	577	36	ligation	ligation	NN
cord-006860-a3b8hyyr	577	37	assay	assay	NN
cord-006860-a3b8hyyr	577	38	.	.	.
cord-006860-a3b8hyyr	578	1	Discussion	discussion	NN
cord-006860-a3b8hyyr	578	2	:	:	:
cord-006860-a3b8hyyr	579	1	The	the	DT
cord-006860-a3b8hyyr	579	2	PCK	PCK	NNP
cord-006860-a3b8hyyr	579	3	-	-	HYPH
cord-006860-a3b8hyyr	579	4	oligonucleotide	oligonucleotide	JJ
cord-006860-a3b8hyyr	579	5	ligation	ligation	NN
cord-006860-a3b8hyyr	579	6	assay	assay	NN
cord-006860-a3b8hyyr	579	7	applied	apply	VBN
cord-006860-a3b8hyyr	579	8	as	as	IN
cord-006860-a3b8hyyr	579	9	automated	automate	VBN
cord-006860-a3b8hyyr	579	10	detection	detection	NN
cord-006860-a3b8hyyr	579	11	system	system	NN
cord-006860-a3b8hyyr	579	12	for	for	IN
cord-006860-a3b8hyyr	579	13	the	the	DT
cord-006860-a3b8hyyr	579	14	identification	identification	NN
cord-006860-a3b8hyyr	579	15	of	of	IN
cord-006860-a3b8hyyr	579	16	the	the	DT
cord-006860-a3b8hyyr	579	17	coagul;mon	coagul;mon	NNP
cord-006860-a3b8hyyr	579	18	factor	factor	NN
cord-006860-a3b8hyyr	579	19	V	v	NN
cord-006860-a3b8hyyr	579	20	point	point	NN
cord-006860-a3b8hyyr	579	21	mutation	mutation	NN
cord-006860-a3b8hyyr	579	22	allows	allow	VBZ
cord-006860-a3b8hyyr	579	23	tile	tile	NN
cord-006860-a3b8hyyr	579	24	rapid	rapid	JJ
cord-006860-a3b8hyyr	579	25	,	,	,
cord-006860-a3b8hyyr	579	26	reliable	reliable	JJ
cord-006860-a3b8hyyr	579	27	,	,	,
cord-006860-a3b8hyyr	579	28	and	and	CC
cord-006860-a3b8hyyr	579	29	large	large	JJ
cord-006860-a3b8hyyr	579	30	scale	scale	NN
cord-006860-a3b8hyyr	579	31	analysis	analysis	NN
cord-006860-a3b8hyyr	579	32	of	of	IN
cord-006860-a3b8hyyr	579	33	patients	patient	NNS
cord-006860-a3b8hyyr	579	34	at	at	IN
cord-006860-a3b8hyyr	579	35	risk	risk	NN
cord-006860-a3b8hyyr	579	36	for	for	IN
cord-006860-a3b8hyyr	579	37	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	579	38	.	.	.
cord-006860-a3b8hyyr	580	1	Resistance	resistance	NN
cord-006860-a3b8hyyr	580	2	to	to	IN
cord-006860-a3b8hyyr	580	3	the	the	DT
cord-006860-a3b8hyyr	580	4	asticoa=	asticoa=	NN
cord-006860-a3b8hyyr	581	1	m	m	LS
cord-006860-a3b8hyyr	582	1	~lant	~lant	CD
cord-006860-a3b8hyyr	582	2	activity	activity	NN
cord-006860-a3b8hyyr	582	3	of	of	IN
cord-006860-a3b8hyyr	582	4	activated	activate	VBN
cord-006860-a3b8hyyr	582	5	protein	protein	NN
cord-006860-a3b8hyyr	582	6	C	C	NNP
cord-006860-a3b8hyyr	582	7	(	(	-LRB-
cord-006860-a3b8hyyr	582	8	APC	APC	NNP
cord-006860-a3b8hyyr	582	9	resistance	resistance	NN
cord-006860-a3b8hyyr	582	10	)	)	-RRB-
cord-006860-a3b8hyyr	582	11	has	have	VBZ
cord-006860-a3b8hyyr	582	12	emerged	emerge	VBN
cord-006860-a3b8hyyr	582	13	as	as	IN
cord-006860-a3b8hyyr	582	14	the	the	DT
cord-006860-a3b8hyyr	582	15	most	most	JJS
cord-006860-a3b8hyyr	582	16	con'anon	con'anon	NN
cord-006860-a3b8hyyr	582	17	inherited	inherit	VBD
cord-006860-a3b8hyyr	582	18	thrombophilic	thrombophilic	JJ
cord-006860-a3b8hyyr	582	19	state	state	NN
cord-006860-a3b8hyyr	582	20	.	.	.
cord-006860-a3b8hyyr	583	1	Patients	patient	NNS
cord-006860-a3b8hyyr	583	2	lreterozygous	lreterozygous	JJ
cord-006860-a3b8hyyr	583	3	for	for	IN
cord-006860-a3b8hyyr	583	4	factor	factor	NN
cord-006860-a3b8hyyr	584	1	V	V	NNP
cord-006860-a3b8hyyr	584	2	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	584	3	are	be	VBP
cord-006860-a3b8hyyr	584	4	more	more	RBR
cord-006860-a3b8hyyr	584	5	likely	likely	JJ
cord-006860-a3b8hyyr	584	6	to	to	TO
cord-006860-a3b8hyyr	584	7	suffer	suffer	VB
cord-006860-a3b8hyyr	584	8	from	from	IN
cord-006860-a3b8hyyr	584	9	thromboembolie	thromboembolie	NNP
cord-006860-a3b8hyyr	584	10	events	event	NNS
cord-006860-a3b8hyyr	584	11	than	than	IN
cord-006860-a3b8hyyr	584	12	controls	control	NNS
cord-006860-a3b8hyyr	584	13	.	.	.
cord-006860-a3b8hyyr	585	1	This	this	DT
cord-006860-a3b8hyyr	585	2	risk	risk	NN
cord-006860-a3b8hyyr	585	3	is	be	VBZ
cord-006860-a3b8hyyr	585	4	even	even	RB
cord-006860-a3b8hyyr	585	5	more	more	RBR
cord-006860-a3b8hyyr	585	6	pronounced	pronounced	JJ
cord-006860-a3b8hyyr	585	7	in	in	IN
cord-006860-a3b8hyyr	585	8	homozygotes	homozygote	NNS
cord-006860-a3b8hyyr	585	9	.	.	.
cord-006860-a3b8hyyr	586	1	Due	due	IN
cord-006860-a3b8hyyr	586	2	to	to	IN
cord-006860-a3b8hyyr	586	3	the	the	DT
cord-006860-a3b8hyyr	586	4	low	low	JJ
cord-006860-a3b8hyyr	586	5	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	586	6	and	and	CC
cord-006860-a3b8hyyr	586	7	speeifity	speeifity	NN
cord-006860-a3b8hyyr	586	8	of	of	IN
cord-006860-a3b8hyyr	586	9	most	most	JJS
cord-006860-a3b8hyyr	586	10	coagulation	coagulation	NN
cord-006860-a3b8hyyr	586	11	tests	test	VBZ
cord-006860-a3b8hyyr	586	12	some	some	DT
cord-006860-a3b8hyyr	586	13	investigators	investigator	NNS
cord-006860-a3b8hyyr	586	14	suggest	suggest	VBP
cord-006860-a3b8hyyr	586	15	to	to	TO
cord-006860-a3b8hyyr	586	16	examine	examine	VB
cord-006860-a3b8hyyr	586	17	patients	patient	NNS
cord-006860-a3b8hyyr	586	18	for	for	IN
cord-006860-a3b8hyyr	586	19	the	the	DT
cord-006860-a3b8hyyr	586	20	presence	presence	NN
cord-006860-a3b8hyyr	586	21	of	of	IN
cord-006860-a3b8hyyr	586	22	Factor	Factor	NNP
cord-006860-a3b8hyyr	586	23	V	V	NNP
cord-006860-a3b8hyyr	586	24	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	586	25	mutation	mutation	NN
cord-006860-a3b8hyyr	586	26	by	by	IN
cord-006860-a3b8hyyr	586	27	PCR	PCR	NNP
cord-006860-a3b8hyyr	586	28	-	-	HYPH
cord-006860-a3b8hyyr	586	29	based	base	VBN
cord-006860-a3b8hyyr	586	30	methods	method	NNS
cord-006860-a3b8hyyr	586	31	.	.	.
cord-006860-a3b8hyyr	587	1	Re	re	IN
cord-006860-a3b8hyyr	587	2	e	e	NN
cord-006860-a3b8hyyr	587	3	~	~	NFP
cord-006860-a3b8hyyr	587	4	tly	tly	RB
cord-006860-a3b8hyyr	587	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	587	6	presented	present	VBD
cord-006860-a3b8hyyr	587	7	an	an	DT
cord-006860-a3b8hyyr	587	8	APTT	APTT	NNP
cord-006860-a3b8hyyr	587	9	-	-	HYPH
cord-006860-a3b8hyyr	587	10	based	base	VBN
cord-006860-a3b8hyyr	587	11	functional	functional	JJ
cord-006860-a3b8hyyr	587	12	test	test	NN
cord-006860-a3b8hyyr	587	13	(	(	-LRB-
cord-006860-a3b8hyyr	587	14	acceleria	acceleria	NNP
cord-006860-a3b8hyyr	587	15	inactivation	inactivation	NNP
cord-006860-a3b8hyyr	587	16	test	test	NN
cord-006860-a3b8hyyr	587	17	AIT	AIT	NNP
cord-006860-a3b8hyyr	587	18	)	)	-RRB-
cord-006860-a3b8hyyr	587	19	:	:	:
cord-006860-a3b8hyyr	587	20	1:20	1:20	CD
cord-006860-a3b8hyyr	587	21	diluted	diluted	JJ
cord-006860-a3b8hyyr	587	22	plasma	plasma	NN
cord-006860-a3b8hyyr	587	23	(	(	-LRB-
cord-006860-a3b8hyyr	587	24	50BI	50bi	CD
cord-006860-a3b8hyyr	587	25	)	)	-RRB-
cord-006860-a3b8hyyr	587	26	is	be	VBZ
cord-006860-a3b8hyyr	587	27	mixed	mix	VBN
cord-006860-a3b8hyyr	587	28	with	with	IN
cord-006860-a3b8hyyr	587	29	factor	factor	NN
cord-006860-a3b8hyyr	587	30	V	v	NN
cord-006860-a3b8hyyr	587	31	deficient	deficient	JJ
cord-006860-a3b8hyyr	587	32	plasma	plasma	NN
cord-006860-a3b8hyyr	587	33	(	(	-LRB-
cord-006860-a3b8hyyr	587	34	50~tl	50~tl	NNP
cord-006860-a3b8hyyr	587	35	)	)	-RRB-
cord-006860-a3b8hyyr	587	36	and	and	CC
cord-006860-a3b8hyyr	587	37	APTT	APTT	NNP
cord-006860-a3b8hyyr	587	38	reagent	reagent	NN
cord-006860-a3b8hyyr	587	39	(	(	-LRB-
cord-006860-a3b8hyyr	587	40	501.d	501.d	CD
cord-006860-a3b8hyyr	587	41	)	)	-RRB-
cord-006860-a3b8hyyr	587	42	,	,	,
cord-006860-a3b8hyyr	587	43	incubated	incubate	VBN
cord-006860-a3b8hyyr	587	44	at	at	IN
cord-006860-a3b8hyyr	587	45	37	37	CD
cord-006860-a3b8hyyr	587	46	°	°	NN
cord-006860-a3b8hyyr	587	47	C	c	NN
cord-006860-a3b8hyyr	587	48	and	and	CC
cord-006860-a3b8hyyr	587	49	then	then	RB
cord-006860-a3b8hyyr	587	50	coagulation	coagulation	NN
cord-006860-a3b8hyyr	587	51	is	be	VBZ
cord-006860-a3b8hyyr	587	52	induced	induce	VBN
cord-006860-a3b8hyyr	587	53	by	by	IN
cord-006860-a3b8hyyr	587	54	CaCI2	CaCI2	NNP
cord-006860-a3b8hyyr	587	55	and	and	CC
cord-006860-a3b8hyyr	587	56	A.PC	A.PC	NNP
cord-006860-a3b8hyyr	587	57	(	(	-LRB-
cord-006860-a3b8hyyr	587	58	50~d	50~d	CD
cord-006860-a3b8hyyr	587	59	)	)	-RRB-
cord-006860-a3b8hyyr	587	60	.	.	.
cord-006860-a3b8hyyr	588	1	Using	use	VBG
cord-006860-a3b8hyyr	588	2	a	a	DT
cord-006860-a3b8hyyr	588	3	standard	standard	JJ
cord-006860-a3b8hyyr	588	4	curve	curve	NN
cord-006860-a3b8hyyr	588	5	,	,	,
cord-006860-a3b8hyyr	588	6	the	the	DT
cord-006860-a3b8hyyr	588	7	clotting	clotting	NN
cord-006860-a3b8hyyr	588	8	time	time	NN
cord-006860-a3b8hyyr	588	9	(	(	-LRB-
cord-006860-a3b8hyyr	588	10	see	see	VB
cord-006860-a3b8hyyr	588	11	)	)	-RRB-
cord-006860-a3b8hyyr	588	12	is	be	VBZ
cord-006860-a3b8hyyr	588	13	transferred	transfer	VBN
cord-006860-a3b8hyyr	588	14	in	in	RP
cord-006860-a3b8hyyr	588	15	per	per	IN
cord-006860-a3b8hyyr	588	16	cent	cent	NN
cord-006860-a3b8hyyr	588	17	accelerin	accelerin	NN
cord-006860-a3b8hyyr	588	18	inactivation	inactivation	NN
cord-006860-a3b8hyyr	588	19	(	(	-LRB-
cord-006860-a3b8hyyr	588	20	%	%	NN
cord-006860-a3b8hyyr	588	21	AI	AI	NNP
cord-006860-a3b8hyyr	588	22	)	)	-RRB-
cord-006860-a3b8hyyr	588	23	.	.	.
cord-006860-a3b8hyyr	589	1	Using	use	VBG
cord-006860-a3b8hyyr	589	2	this	this	DT
cord-006860-a3b8hyyr	589	3	test	test	NN
cord-006860-a3b8hyyr	589	4	,	,	,
cord-006860-a3b8hyyr	589	5	the	the	DT
cord-006860-a3b8hyyr	589	6	widely	widely	RB
cord-006860-a3b8hyyr	589	7	used	use	VBN
cord-006860-a3b8hyyr	589	8	APC	APC	NNP
cord-006860-a3b8hyyr	589	9	-	-	HYPH
cord-006860-a3b8hyyr	589	10	ratio	ratio	NN
cord-006860-a3b8hyyr	589	11	as	as	RB
cord-006860-a3b8hyyr	589	12	well	well	RB
cord-006860-a3b8hyyr	589	13	as	as	IN
cord-006860-a3b8hyyr	589	14	PCR	PCR	NNP
cord-006860-a3b8hyyr	589	15	-	-	HYPH
cord-006860-a3b8hyyr	589	16	based	base	VBN
cord-006860-a3b8hyyr	589	17	factor	factor	NN
cord-006860-a3b8hyyr	589	18	V	V	NNP
cord-006860-a3b8hyyr	589	19	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	589	20	detection	detection	NN
cord-006860-a3b8hyyr	589	21	(	(	-LRB-
cord-006860-a3b8hyyr	589	22	confirmed	confirm	VBN
cord-006860-a3b8hyyr	589	23	by	by	IN
cord-006860-a3b8hyyr	589	24	direct	direct	JJ
cord-006860-a3b8hyyr	589	25	sequencing	sequencing	NN
cord-006860-a3b8hyyr	589	26	)	)	-RRB-
cord-006860-a3b8hyyr	589	27	we	-PRON-	PRP
cord-006860-a3b8hyyr	589	28	prospectively	prospectively	RB
cord-006860-a3b8hyyr	589	29	studied	study	VBD
cord-006860-a3b8hyyr	589	30	172	172	CD
cord-006860-a3b8hyyr	589	31	consecutive	consecutive	JJ
cord-006860-a3b8hyyr	589	32	patients	patient	NNS
cord-006860-a3b8hyyr	589	33	with	with	IN
cord-006860-a3b8hyyr	589	34	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	589	35	events	event	NNS
cord-006860-a3b8hyyr	589	36	.	.	.
cord-006860-a3b8hyyr	590	1	Patients	patient	NNS
cord-006860-a3b8hyyr	590	2	without	without	IN
cord-006860-a3b8hyyr	590	3	the	the	DT
cord-006860-a3b8hyyr	590	4	factor	factor	NN
cord-006860-a3b8hyyr	590	5	V	V	NNP
cord-006860-a3b8hyyr	590	6	mntation	mntation	NNP
cord-006860-a3b8hyyr	590	7	eonsitently	eonsitently	RB
cord-006860-a3b8hyyr	590	8	showed	show	VBD
cord-006860-a3b8hyyr	590	9	more	more	JJR
cord-006860-a3b8hyyr	590	10	flazm	flazm	JJ
cord-006860-a3b8hyyr	590	11	50	50	CD
cord-006860-a3b8hyyr	590	12	%	%	NN
cord-006860-a3b8hyyr	590	13	AL	AL	NNP
cord-006860-a3b8hyyr	591	1	With	with	IN
cord-006860-a3b8hyyr	591	2	the	the	DT
cord-006860-a3b8hyyr	591	3	exception	exception	NN
cord-006860-a3b8hyyr	591	4	of	of	IN
cord-006860-a3b8hyyr	591	5	one	one	CD
cord-006860-a3b8hyyr	591	6	patient	patient	NN
cord-006860-a3b8hyyr	591	7	with	with	IN
cord-006860-a3b8hyyr	591	8	severe	severe	JJ
cord-006860-a3b8hyyr	591	9	factor	factor	NN
cord-006860-a3b8hyyr	591	10	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	591	11	(	(	-LRB-
cord-006860-a3b8hyyr	591	12	including	include	VBG
cord-006860-a3b8hyyr	591	13	factor	factor	NN
cord-006860-a3b8hyyr	591	14	V	v	NN
cord-006860-a3b8hyyr	591	15	)	)	-RRB-
cord-006860-a3b8hyyr	591	16	due	due	IN
cord-006860-a3b8hyyr	591	17	to	to	IN
cord-006860-a3b8hyyr	591	18	hepatic	hepatic	JJ
cord-006860-a3b8hyyr	591	19	failure	failure	NN
cord-006860-a3b8hyyr	591	20	and	and	CC
cord-006860-a3b8hyyr	591	21	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	591	22	for	for	IN
cord-006860-a3b8hyyr	591	23	factor	factor	NN
cord-006860-a3b8hyyr	591	24	V	V	NNP
cord-006860-a3b8hyyr	591	25	-	-	HYPH
cord-006860-a3b8hyyr	591	26	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	591	27	resulting	result	VBG
cord-006860-a3b8hyyr	591	28	in	in	IN
cord-006860-a3b8hyyr	591	29	62*/.	62*/.	CD
cord-006860-a3b8hyyr	591	30	AI	ai	NN
cord-006860-a3b8hyyr	591	31	,	,	,
cord-006860-a3b8hyyr	591	32	there	there	EX
cord-006860-a3b8hyyr	591	33	was	be	VBD
cord-006860-a3b8hyyr	591	34	a	a	DT
cord-006860-a3b8hyyr	591	35	complete	complete	JJ
cord-006860-a3b8hyyr	591	36	concordance	concordance	NN
cord-006860-a3b8hyyr	591	37	between	between	IN
cord-006860-a3b8hyyr	591	38	the	the	DT
cord-006860-a3b8hyyr	591	39	PCRbased	pcrbase	VBN
cord-006860-a3b8hyyr	591	40	method	method	NN
cord-006860-a3b8hyyr	591	41	and	and	CC
cord-006860-a3b8hyyr	591	42	dysaseelerinemia	dysaseelerinemia	NN
cord-006860-a3b8hyyr	591	43	detected	detect	VBN
cord-006860-a3b8hyyr	591	44	by	by	IN
cord-006860-a3b8hyyr	591	45	AIT	AIT	NNP
cord-006860-a3b8hyyr	591	46	.	.	.
cord-006860-a3b8hyyr	592	1	Due	due	IN
cord-006860-a3b8hyyr	592	2	to	to	IN
cord-006860-a3b8hyyr	592	3	these	these	DT
cord-006860-a3b8hyyr	592	4	result	result	VB
cord-006860-a3b8hyyr	592	5	a	a	DT
cord-006860-a3b8hyyr	592	6	specifity	specifity	NN
cord-006860-a3b8hyyr	592	7	and	and	CC
cord-006860-a3b8hyyr	592	8	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	592	9	of	of	IN
cord-006860-a3b8hyyr	592	10	AIT	AIT	NNP
cord-006860-a3b8hyyr	592	11	above	above	IN
cord-006860-a3b8hyyr	592	12	95	95	CD
cord-006860-a3b8hyyr	592	13	%	%	NN
cord-006860-a3b8hyyr	592	14	was	be	VBD
cord-006860-a3b8hyyr	592	15	calculated	calculate	VBN
cord-006860-a3b8hyyr	592	16	.	.	.
cord-006860-a3b8hyyr	593	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	593	2	,	,	,
cord-006860-a3b8hyyr	593	3	a	a	DT
cord-006860-a3b8hyyr	593	4	clear	clear	JJ
cord-006860-a3b8hyyr	593	5	discrimination	discrimination	NN
cord-006860-a3b8hyyr	593	6	could	could	MD
cord-006860-a3b8hyyr	593	7	be	be	VB
cord-006860-a3b8hyyr	593	8	obsoved	obsove	VBN
cord-006860-a3b8hyyr	593	9	beween	beween	IN
cord-006860-a3b8hyyr	593	10	34	34	CD
cord-006860-a3b8hyyr	593	11	heterozygotes	heterozygote	NNS
cord-006860-a3b8hyyr	593	12	(	(	-LRB-
cord-006860-a3b8hyyr	593	13	20%<AI<50	20%<ai<50	CD
cord-006860-a3b8hyyr	593	14	%	%	NN
cord-006860-a3b8hyyr	593	15	)	)	-RRB-
cord-006860-a3b8hyyr	593	16	and	and	CC
cord-006860-a3b8hyyr	593	17	8	8	CD
cord-006860-a3b8hyyr	593	18	(	(	-LRB-
cord-006860-a3b8hyyr	593	19	incl	incl	NNS
cord-006860-a3b8hyyr	593	20	.	.	.
cord-006860-a3b8hyyr	594	1	5	5	CD
cord-006860-a3b8hyyr	594	2	samples	sample	NNS
cord-006860-a3b8hyyr	594	3	obtained	obtain	VBN
cord-006860-a3b8hyyr	594	4	from	from	IN
cord-006860-a3b8hyyr	594	5	Jeaa	Jeaa	NNP
cord-006860-a3b8hyyr	594	6	)	)	-RRB-
cord-006860-a3b8hyyr	594	7	homozygotes	homozygote	NNS
cord-006860-a3b8hyyr	594	8	(	(	-LRB-
cord-006860-a3b8hyyr	594	9	AI<20	AI<20	NNP
cord-006860-a3b8hyyr	594	10	%	%	NN
cord-006860-a3b8hyyr	594	11	)	)	-RRB-
cord-006860-a3b8hyyr	594	12	.	.	.
cord-006860-a3b8hyyr	595	1	In	in	IN
cord-006860-a3b8hyyr	595	2	contrast	contrast	NN
cord-006860-a3b8hyyr	595	3	A.PC	A.PC	NNS
cord-006860-a3b8hyyr	595	4	-	-	HYPH
cord-006860-a3b8hyyr	595	5	ratio	ratio	NN
cord-006860-a3b8hyyr	595	6	resulted	result	VBD
cord-006860-a3b8hyyr	595	7	in	in	IN
cord-006860-a3b8hyyr	595	8	a	a	DT
cord-006860-a3b8hyyr	595	9	great	great	JJ
cord-006860-a3b8hyyr	595	10	overlap	overlap	NN
cord-006860-a3b8hyyr	595	11	between	between	IN
cord-006860-a3b8hyyr	595	12	patients	patient	NNS
cord-006860-a3b8hyyr	595	13	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	595	14	for	for	IN
cord-006860-a3b8hyyr	595	15	the	the	DT
cord-006860-a3b8hyyr	595	16	wildtype	wildtype	NN
cord-006860-a3b8hyyr	595	17	,	,	,
cord-006860-a3b8hyyr	595	18	hcterozgous	hcterozgous	JJ
cord-006860-a3b8hyyr	595	19	or	or	CC
cord-006860-a3b8hyyr	595	20	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	595	21	for	for	IN
cord-006860-a3b8hyyr	595	22	factor	factor	NN
cord-006860-a3b8hyyr	595	23	V	V	NNP
cord-006860-a3b8hyyr	595	24	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	595	25	.	.	.
cord-006860-a3b8hyyr	596	1	In	in	IN
cord-006860-a3b8hyyr	596	2	addition	addition	NN
cord-006860-a3b8hyyr	596	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	596	4	confirmed	confirm	VBD
cord-006860-a3b8hyyr	596	5	thc	thc	NNP
cord-006860-a3b8hyyr	596	6	di.~eulties	di.~eultie	NNS
cord-006860-a3b8hyyr	596	7	nsing	nse	VBG
cord-006860-a3b8hyyr	596	8	the	the	DT
cord-006860-a3b8hyyr	596	9	APC	APC	NNP
cord-006860-a3b8hyyr	596	10	-	-	HYPH
cord-006860-a3b8hyyr	596	11	raUo	raUo	NNP
cord-006860-a3b8hyyr	596	12	for	for	IN
cord-006860-a3b8hyyr	596	13	patients	patient	NNS
cord-006860-a3b8hyyr	596	14	trader	trader	NN
cord-006860-a3b8hyyr	596	15	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	596	16	,	,	,
cord-006860-a3b8hyyr	596	17	or	or	CC
cord-006860-a3b8hyyr	596	18	with	with	IN
cord-006860-a3b8hyyr	596	19	different	different	JJ
cord-006860-a3b8hyyr	596	20	types	type	NNS
cord-006860-a3b8hyyr	596	21	of	of	IN
cord-006860-a3b8hyyr	596	22	other	other	JJ
cord-006860-a3b8hyyr	596	23	d	d	NN
cord-006860-a3b8hyyr	596	24	~	~	CD
cord-006860-a3b8hyyr	596	25	rombophilie	rombophilie	NNP
cord-006860-a3b8hyyr	596	26	defects	defect	NNS
cord-006860-a3b8hyyr	596	27	such	such	JJ
cord-006860-a3b8hyyr	596	28	as	as	IN
cord-006860-a3b8hyyr	596	29	lupus	lupus	NN
cord-006860-a3b8hyyr	596	30	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	596	31	or	or	CC
cord-006860-a3b8hyyr	596	32	protein	protein	NN
cord-006860-a3b8hyyr	596	33	S	S	NNP
cord-006860-a3b8hyyr	596	34	deficiency	deficiency	NN
cord-006860-a3b8hyyr	596	35	.	.	.
cord-006860-a3b8hyyr	597	1	Due	due	IN
cord-006860-a3b8hyyr	597	2	to	to	IN
cord-006860-a3b8hyyr	597	3	the	the	DT
cord-006860-a3b8hyyr	597	4	time	time	NN
cord-006860-a3b8hyyr	597	5	and	and	CC
cord-006860-a3b8hyyr	597	6	cost	cost	NN
cord-006860-a3b8hyyr	597	7	-	-	HYPH
cord-006860-a3b8hyyr	597	8	saving	save	VBG
cord-006860-a3b8hyyr	597	9	featttres	featttre	NNS
cord-006860-a3b8hyyr	597	10	the	the	DT
cord-006860-a3b8hyyr	597	11	/	/	SYM
cord-006860-a3b8hyyr	597	12	kiT	kiT	NNP
cord-006860-a3b8hyyr	597	13	should	should	MD
cord-006860-a3b8hyyr	597	14	be	be	VB
cord-006860-a3b8hyyr	597	15	considered	consider	VBN
cord-006860-a3b8hyyr	597	16	for	for	IN
cord-006860-a3b8hyyr	597	17	the	the	DT
cord-006860-a3b8hyyr	597	18	rapid	rapid	JJ
cord-006860-a3b8hyyr	597	19	detection	detection	NN
cord-006860-a3b8hyyr	597	20	of	of	IN
cord-006860-a3b8hyyr	597	21	APC	APC	NNP
cord-006860-a3b8hyyr	597	22	resistance	resistance	NN
cord-006860-a3b8hyyr	597	23	without	without	IN
cord-006860-a3b8hyyr	597	24	the	the	DT
cord-006860-a3b8hyyr	597	25	use	use	NN
cord-006860-a3b8hyyr	597	26	of	of	IN
cord-006860-a3b8hyyr	597	27	PCR	PCR	NNP
cord-006860-a3b8hyyr	597	28	-	-	HYPH
cord-006860-a3b8hyyr	597	29	based	base	VBN
cord-006860-a3b8hyyr	597	30	techniques	technique	NNS
cord-006860-a3b8hyyr	597	31	.	.	.
cord-006860-a3b8hyyr	598	1	In	in	IN
cord-006860-a3b8hyyr	598	2	summary	summary	NN
cord-006860-a3b8hyyr	598	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	598	4	found	find	VBD
cord-006860-a3b8hyyr	598	5	,	,	,
cord-006860-a3b8hyyr	598	6	well	well	RB
cord-006860-a3b8hyyr	598	7	in	in	IN
cord-006860-a3b8hyyr	598	8	accordance	accordance	NN
cord-006860-a3b8hyyr	598	9	with	with	IN
cord-006860-a3b8hyyr	598	10	previous	previous	JJ
cord-006860-a3b8hyyr	598	11	reports	report	NNS
cord-006860-a3b8hyyr	598	12	,	,	,
cord-006860-a3b8hyyr	598	13	that	that	IN
cord-006860-a3b8hyyr	598	14	APCR	APCR	NNP
cord-006860-a3b8hyyr	598	15	due	due	IN
cord-006860-a3b8hyyr	598	16	to	to	IN
cord-006860-a3b8hyyr	598	17	the	the	DT
cord-006860-a3b8hyyr	598	18	FV	FV	NNP
cord-006860-a3b8hyyr	598	19	-	-	HYPH
cord-006860-a3b8hyyr	598	20	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	598	21	mutation	mutation	NN
cord-006860-a3b8hyyr	598	22	is	be	VBZ
cord-006860-a3b8hyyr	598	23	•	•	NNP
cord-006860-a3b8hyyr	598	24	highly	highly	RB
cord-006860-a3b8hyyr	598	25	prevalent	prevalent	JJ
cord-006860-a3b8hyyr	598	26	defect	defect	NN
cord-006860-a3b8hyyr	598	27	in	in	IN
cord-006860-a3b8hyyr	598	28	VTE	VTE	NNP
cord-006860-a3b8hyyr	598	29	pts	pts	NNP
cord-006860-a3b8hyyr	598	30	.	.	.
cord-006860-a3b8hyyr	599	1	Pts	Pts	NNP
cord-006860-a3b8hyyr	599	2	with	with	IN
cord-006860-a3b8hyyr	599	3	the	the	DT
cord-006860-a3b8hyyr	599	4	FV	FV	NNP
cord-006860-a3b8hyyr	599	5	-	-	HYPH
cord-006860-a3b8hyyr	599	6	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	599	7	mutation	mutation	NN
cord-006860-a3b8hyyr	599	8	were	be	VBD
cord-006860-a3b8hyyr	599	9	eharacterised	eharacterise	VBN
cord-006860-a3b8hyyr	599	10	by	by	IN
cord-006860-a3b8hyyr	599	11	a	a	DT
cord-006860-a3b8hyyr	599	12	higher	high	JJR
cord-006860-a3b8hyyr	599	13	incidence	incidence	NN
cord-006860-a3b8hyyr	599	14	of	of	IN
cord-006860-a3b8hyyr	599	15	VTE	VTE	NNP
cord-006860-a3b8hyyr	599	16	's	's	POS
cord-006860-a3b8hyyr	599	17	without	without	IN
cord-006860-a3b8hyyr	599	18	recognised	recognise	VBN
cord-006860-a3b8hyyr	599	19	prothrombotic	prothrombotic	JJ
cord-006860-a3b8hyyr	599	20	risk	risk	NN
cord-006860-a3b8hyyr	599	21	factors	factor	NNS
cord-006860-a3b8hyyr	599	22	and	and	CC
cord-006860-a3b8hyyr	599	23	more	more	RBR
cord-006860-a3b8hyyr	599	24	frequent	frequent	JJ
cord-006860-a3b8hyyr	599	25	positive	positive	JJ
cord-006860-a3b8hyyr	599	26	family	family	NN
cord-006860-a3b8hyyr	599	27	history	history	NN
cord-006860-a3b8hyyr	599	28	;	;	:
cord-006860-a3b8hyyr	599	29	no	no	DT
cord-006860-a3b8hyyr	599	30	higher	high	JJR
cord-006860-a3b8hyyr	599	31	incidence	incidence	NN
cord-006860-a3b8hyyr	599	32	of	of	IN
cord-006860-a3b8hyyr	599	33	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	599	34	VTE	VTE	NNP
cord-006860-a3b8hyyr	599	35	's	's	POS
cord-006860-a3b8hyyr	599	36	or	or	CC
cord-006860-a3b8hyyr	599	37	other	other	JJ
cord-006860-a3b8hyyr	599	38	prothrombotie	prothrombotie	NN
cord-006860-a3b8hyyr	599	39	coagulation	coagulation	NN
cord-006860-a3b8hyyr	599	40	defects	defect	NNS
cord-006860-a3b8hyyr	599	41	was	be	VBD
cord-006860-a3b8hyyr	599	42	found	find	VBN
cord-006860-a3b8hyyr	599	43	;	;	:
cord-006860-a3b8hyyr	599	44	the	the	DT
cord-006860-a3b8hyyr	599	45	age	age	NN
cord-006860-a3b8hyyr	599	46	at	at	IN
cord-006860-a3b8hyyr	599	47	initial	initial	JJ
cord-006860-a3b8hyyr	599	48	manifestation	manifestation	NN
cord-006860-a3b8hyyr	599	49	of	of	IN
cord-006860-a3b8hyyr	599	50	thrombophitia	thrombophitia	NN
cord-006860-a3b8hyyr	599	51	was	be	VBD
cord-006860-a3b8hyyr	599	52	comparable	comparable	JJ
cord-006860-a3b8hyyr	599	53	.	.	.
cord-006860-a3b8hyyr	600	1	ACQUIRED	acquire	VBN
cord-006860-a3b8hyyr	601	1	A	a	DT
cord-006860-a3b8hyyr	601	2	recently	recently	RB
cord-006860-a3b8hyyr	601	3	identified	identify	VBN
cord-006860-a3b8hyyr	601	4	mechanism	mechanism	NN
cord-006860-a3b8hyyr	601	5	for	for	IN
cord-006860-a3b8hyyr	601	6	famdial	famdial	NNP
cord-006860-a3b8hyyr	601	7	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	601	8	is	be	VBZ
cord-006860-a3b8hyyr	601	9	characterized	characterize	VBN
cord-006860-a3b8hyyr	601	10	by	by	IN
cord-006860-a3b8hyyr	601	11	a	a	DT
cord-006860-a3b8hyyr	601	12	poor	poor	JJ
cord-006860-a3b8hyyr	601	13	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	601	14	response	response	NN
cord-006860-a3b8hyyr	601	15	to	to	IN
cord-006860-a3b8hyyr	601	16	actavated	actavated	JJ
cord-006860-a3b8hyyr	601	17	protein	protein	NN
cord-006860-a3b8hyyr	601	18	C	C	NNP
cord-006860-a3b8hyyr	601	19	(	(	-LRB-
cord-006860-a3b8hyyr	601	20	APC	APC	NNP
cord-006860-a3b8hyyr	601	21	)	)	-RRB-
cord-006860-a3b8hyyr	601	22	,	,	,
cord-006860-a3b8hyyr	601	23	It	-PRON-	PRP
cord-006860-a3b8hyyr	601	24	is	be	VBZ
cord-006860-a3b8hyyr	601	25	now	now	RB
cord-006860-a3b8hyyr	601	26	welt	welt	NN
cord-006860-a3b8hyyr	601	27	recoginzed	recoginze	VBN
cord-006860-a3b8hyyr	601	28	to	to	TO
cord-006860-a3b8hyyr	601	29	be	be	VB
cord-006860-a3b8hyyr	601	30	due	due	JJ
cord-006860-a3b8hyyr	601	31	to	to	IN
cord-006860-a3b8hyyr	601	32	a	a	DT
cord-006860-a3b8hyyr	601	33	genetic	genetic	JJ
cord-006860-a3b8hyyr	601	34	defect	defect	NN
cord-006860-a3b8hyyr	601	35	in	in	IN
cord-006860-a3b8hyyr	601	36	the	the	DT
cord-006860-a3b8hyyr	601	37	factor	factor	NN
cord-006860-a3b8hyyr	601	38	V	v	NN
cord-006860-a3b8hyyr	601	39	gene	gene	NN
cord-006860-a3b8hyyr	601	40	,	,	,
cord-006860-a3b8hyyr	601	41	which	which	WDT
cord-006860-a3b8hyyr	601	42	results	result	VBZ
cord-006860-a3b8hyyr	601	43	in	in	IN
cord-006860-a3b8hyyr	601	44	the	the	DT
cord-006860-a3b8hyyr	601	45	syn-,thesis	syn-,thesis	NN
cord-006860-a3b8hyyr	601	46	of	of	IN
cord-006860-a3b8hyyr	601	47	an	an	DT
cord-006860-a3b8hyyr	601	48	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	601	49	factor	factor	NN
cord-006860-a3b8hyyr	601	50	V	v	NN
cord-006860-a3b8hyyr	601	51	molecule	molecule	NN
cord-006860-a3b8hyyr	601	52	and	and	CC
cord-006860-a3b8hyyr	601	53	to	to	TO
cord-006860-a3b8hyyr	601	54	be	be	VB
cord-006860-a3b8hyyr	601	55	a	a	DT
cord-006860-a3b8hyyr	601	56	frequent	frequent	JJ
cord-006860-a3b8hyyr	601	57	risk	risk	NN
cord-006860-a3b8hyyr	601	58	factor	factor	NN
cord-006860-a3b8hyyr	601	59	for	for	IN
cord-006860-a3b8hyyr	601	60	thromb.osis	thromb.osis	NN
cord-006860-a3b8hyyr	601	61	,	,	,
cord-006860-a3b8hyyr	601	62	however	however	RB
cord-006860-a3b8hyyr	601	63	APC	APC	NNP
cord-006860-a3b8hyyr	601	64	resistenee	resistenee	NNP
cord-006860-a3b8hyyr	601	65	can	can	MD
cord-006860-a3b8hyyr	601	66	also	also	RB
cord-006860-a3b8hyyr	601	67	be	be	VB
cord-006860-a3b8hyyr	601	68	found	find	VBN
cord-006860-a3b8hyyr	601	69	in	in	IN
cord-006860-a3b8hyyr	601	70	certain	certain	JJ
cord-006860-a3b8hyyr	601	71	acquired	acquire	VBN
cord-006860-a3b8hyyr	601	72	conditions	condition	NNS
cord-006860-a3b8hyyr	601	73	.	.	.
cord-006860-a3b8hyyr	602	1	Since	since	IN
cord-006860-a3b8hyyr	602	2	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	602	3	~s	~s	NNP
cord-006860-a3b8hyyr	602	4	known	know	VBN
cord-006860-a3b8hyyr	602	5	to	to	TO
cord-006860-a3b8hyyr	602	6	be	be	VB
cord-006860-a3b8hyyr	602	7	associated	associate	VBN
cord-006860-a3b8hyyr	602	8	with	with	IN
cord-006860-a3b8hyyr	602	9	a	a	DT
cord-006860-a3b8hyyr	602	10	hypercongulable	hypercongulable	JJ
cord-006860-a3b8hyyr	602	11	state	state	NN
cord-006860-a3b8hyyr	602	12	resulting	result	VBG
cord-006860-a3b8hyyr	602	13	in	in	IN
cord-006860-a3b8hyyr	602	14	a	a	DT
cord-006860-a3b8hyyr	602	15	prevalance	prevalance	NN
cord-006860-a3b8hyyr	602	16	of	of	IN
cord-006860-a3b8hyyr	602	17	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	602	18	up	up	IN
cord-006860-a3b8hyyr	602	19	to	to	IN
cord-006860-a3b8hyyr	602	20	1	1	CD
cord-006860-a3b8hyyr	602	21	%	%	NN
cord-006860-a3b8hyyr	602	22	and	and	CC
cord-006860-a3b8hyyr	602	23	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	602	24	events	event	NNS
cord-006860-a3b8hyyr	602	25	,	,	,
cord-006860-a3b8hyyr	602	26	we	-PRON-	PRP
cord-006860-a3b8hyyr	602	27	determined	determine	VBD
cord-006860-a3b8hyyr	602	28	the	the	DT
cord-006860-a3b8hyyr	602	29	prevalence	prevalence	NN
cord-006860-a3b8hyyr	602	30	of	of	IN
cord-006860-a3b8hyyr	602	31	APC	APC	NNP
cord-006860-a3b8hyyr	602	32	resistance	resistance	NN
cord-006860-a3b8hyyr	602	33	during	during	IN
cord-006860-a3b8hyyr	602	34	the	the	DT
cord-006860-a3b8hyyr	602	35	course	course	NN
cord-006860-a3b8hyyr	602	36	of	of	IN
cord-006860-a3b8hyyr	602	37	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	602	38	at	at	IN
cord-006860-a3b8hyyr	602	39	the	the	DT
cord-006860-a3b8hyyr	602	40	City	City	NNP
cord-006860-a3b8hyyr	602	41	Hoslfital	Hoslfital	NNP
cord-006860-a3b8hyyr	602	42	Ruesselsbeim	Ruesselsbeim	NNP
cord-006860-a3b8hyyr	602	43	.	.	.
cord-006860-a3b8hyyr	603	1	Germany	Germany	NNP
cord-006860-a3b8hyyr	603	2	.	.	.
cord-006860-a3b8hyyr	604	1	Blood	blood	NN
cord-006860-a3b8hyyr	604	2	samples	sample	NNS
cord-006860-a3b8hyyr	604	3	from	from	IN
cord-006860-a3b8hyyr	604	4	pregnant	pregnant	JJ
cord-006860-a3b8hyyr	604	5	woman	woman	NN
cord-006860-a3b8hyyr	604	6	were	be	VBD
cord-006860-a3b8hyyr	604	7	drawn	draw	VBN
cord-006860-a3b8hyyr	604	8	at	at	IN
cord-006860-a3b8hyyr	604	9	mmester	mmester	NNP
cord-006860-a3b8hyyr	604	10	1	1	CD
cord-006860-a3b8hyyr	604	11	,	,	,
cord-006860-a3b8hyyr	604	12	2	2	CD
cord-006860-a3b8hyyr	604	13	,	,	,
cord-006860-a3b8hyyr	604	14	3	3	CD
cord-006860-a3b8hyyr	604	15	and	and	CC
cord-006860-a3b8hyyr	604	16	at	at	IN
cord-006860-a3b8hyyr	604	17	term	term	NN
cord-006860-a3b8hyyr	604	18	.	.	.
cord-006860-a3b8hyyr	605	1	Besides	besides	IN
cord-006860-a3b8hyyr	605	2	the	the	DT
cord-006860-a3b8hyyr	605	3	routine	routine	JJ
cord-006860-a3b8hyyr	605	4	coagulatton	coagulatton	NN
cord-006860-a3b8hyyr	605	5	screening	screening	NN
cord-006860-a3b8hyyr	605	6	,	,	,
cord-006860-a3b8hyyr	605	7	protein	protein	NN
cord-006860-a3b8hyyr	605	8	C	C	NNP
cord-006860-a3b8hyyr	605	9	and	and	CC
cord-006860-a3b8hyyr	605	10	VIII	VIII	NNP
cord-006860-a3b8hyyr	605	11	:	:	:
cord-006860-a3b8hyyr	605	12	C	C	NNP
cord-006860-a3b8hyyr	605	13	,	,	,
cord-006860-a3b8hyyr	605	14	the	the	DT
cord-006860-a3b8hyyr	605	15	APC	APC	NNP
cord-006860-a3b8hyyr	605	16	resistance	resistance	NN
cord-006860-a3b8hyyr	605	17	were	be	VBD
cord-006860-a3b8hyyr	605	18	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	605	19	.	.	.
cord-006860-a3b8hyyr	606	1	A	a	DT
cord-006860-a3b8hyyr	606	2	modified	modify	VBN
cord-006860-a3b8hyyr	606	3	APTT	APTT	NNP
cord-006860-a3b8hyyr	606	4	method	method	NN
cord-006860-a3b8hyyr	606	5	utilizing	utilize	VBG
cord-006860-a3b8hyyr	606	6	human	human	JJ
cord-006860-a3b8hyyr	606	7	plasma	plasma	NN
cord-006860-a3b8hyyr	606	8	fracnonated	fracnonate	VBD
cord-006860-a3b8hyyr	606	9	APC	APC	NNP
cord-006860-a3b8hyyr	606	10	(	(	-LRB-
cord-006860-a3b8hyyr	606	11	Amencan	Amencan	NNP
cord-006860-a3b8hyyr	606	12	Red	Red	NNP
cord-006860-a3b8hyyr	606	13	Cross	Cross	NNP
cord-006860-a3b8hyyr	606	14	.	.	.
cord-006860-a3b8hyyr	607	1	Bethesda	Bethesda	NNP
cord-006860-a3b8hyyr	607	2	,	,	,
cord-006860-a3b8hyyr	607	3	Maryland	Maryland	NNP
cord-006860-a3b8hyyr	607	4	,	,	,
cord-006860-a3b8hyyr	607	5	~USA	~USA	NNP
cord-006860-a3b8hyyr	607	6	)	)	-RRB-
cord-006860-a3b8hyyr	607	7	was	be	VBD
cord-006860-a3b8hyyr	607	8	used	use	VBN
cord-006860-a3b8hyyr	607	9	to	to	TO
cord-006860-a3b8hyyr	607	10	assay	assay	VB
cord-006860-a3b8hyyr	607	11	APC	APC	NNP
cord-006860-a3b8hyyr	607	12	resistance	resistance	NN
cord-006860-a3b8hyyr	607	13	.	.	.
cord-006860-a3b8hyyr	608	1	This	this	DT
cord-006860-a3b8hyyr	608	2	method	method	NN
cord-006860-a3b8hyyr	608	3	relies	rely	VBZ
cord-006860-a3b8hyyr	608	4	on	on	IN
cord-006860-a3b8hyyr	608	5	the	the	DT
cord-006860-a3b8hyyr	608	6	determination	determination	NN
cord-006860-a3b8hyyr	608	7	of	of	IN
cord-006860-a3b8hyyr	608	8	two	two	CD
cord-006860-a3b8hyyr	608	9	APTT	APTT	NNP
cord-006860-a3b8hyyr	608	10	's	's	POS
cord-006860-a3b8hyyr	608	11	in	in	IN
cord-006860-a3b8hyyr	608	12	the	the	DT
cord-006860-a3b8hyyr	608	13	patient	patient	NN
cord-006860-a3b8hyyr	608	14	plasma	plasma	NN
cord-006860-a3b8hyyr	608	15	,	,	,
cord-006860-a3b8hyyr	608	16	one	one	CD
cord-006860-a3b8hyyr	608	17	in	in	IN
cord-006860-a3b8hyyr	608	18	the	the	DT
cord-006860-a3b8hyyr	608	19	absence	absence	NN
cord-006860-a3b8hyyr	608	20	of	of	IN
cord-006860-a3b8hyyr	608	21	APC	APC	NNP
cord-006860-a3b8hyyr	608	22	and	and	CC
cord-006860-a3b8hyyr	608	23	one	one	CD
cord-006860-a3b8hyyr	608	24	in	in	IN
cord-006860-a3b8hyyr	608	25	the	the	DT
cord-006860-a3b8hyyr	608	26	presence	presence	NN
cord-006860-a3b8hyyr	608	27	of	of	IN
cord-006860-a3b8hyyr	608	28	a	a	DT
cord-006860-a3b8hyyr	608	29	fixed	fix	VBN
cord-006860-a3b8hyyr	608	30	amount	amount	NN
cord-006860-a3b8hyyr	608	31	of	of	IN
cord-006860-a3b8hyyr	608	32	APC	APC	NNP
cord-006860-a3b8hyyr	608	33	.	.	.
cord-006860-a3b8hyyr	609	1	Clotting	clotting	NN
cord-006860-a3b8hyyr	609	2	tune	tune	NN
cord-006860-a3b8hyyr	609	3	was	be	VBD
cord-006860-a3b8hyyr	609	4	determined	determine	VBN
cord-006860-a3b8hyyr	609	5	after	after	IN
cord-006860-a3b8hyyr	609	6	mcubation	mcubation	NN
cord-006860-a3b8hyyr	609	7	using	use	VBG
cord-006860-a3b8hyyr	609	8	the	the	DT
cord-006860-a3b8hyyr	609	9	APTT	APTT	NNP
cord-006860-a3b8hyyr	609	10	reagent	reagent	NN
cord-006860-a3b8hyyr	609	11	(	(	-LRB-
cord-006860-a3b8hyyr	609	12	We	-PRON-	PRP
cord-006860-a3b8hyyr	609	13	investigated	investigate	VBD
cord-006860-a3b8hyyr	609	14	the	the	DT
cord-006860-a3b8hyyr	609	15	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	609	16	of	of	IN
cord-006860-a3b8hyyr	609	17	various	various	JJ
cord-006860-a3b8hyyr	609	18	species	specie	NNS
cord-006860-a3b8hyyr	609	19	towards	towards	IN
cord-006860-a3b8hyyr	609	20	activated	activate	VBN
cord-006860-a3b8hyyr	609	21	,	,	,
cord-006860-a3b8hyyr	609	22	human	human	JJ
cord-006860-a3b8hyyr	609	23	protein	protein	NN
cord-006860-a3b8hyyr	609	24	C	C	NNP
cord-006860-a3b8hyyr	609	25	(	(	-LRB-
cord-006860-a3b8hyyr	609	26	APC	APC	NNP
cord-006860-a3b8hyyr	609	27	)	)	-RRB-
cord-006860-a3b8hyyr	609	28	and	and	CC
cord-006860-a3b8hyyr	609	29	found	find	VBD
cord-006860-a3b8hyyr	609	30	an	an	DT
cord-006860-a3b8hyyr	609	31	impaired	impaired	JJ
cord-006860-a3b8hyyr	609	32	response	response	NN
cord-006860-a3b8hyyr	609	33	in	in	IN
cord-006860-a3b8hyyr	609	34	the	the	DT
cord-006860-a3b8hyyr	609	35	order	order	NN
cord-006860-a3b8hyyr	609	36	monkey	monkey	NNP
cord-006860-a3b8hyyr	609	37	<	<	XX
cord-006860-a3b8hyyr	609	38	horse	horse	NNP
cord-006860-a3b8hyyr	609	39	<	<	XX
cord-006860-a3b8hyyr	609	40	pig	pig	NNP
cord-006860-a3b8hyyr	609	41	<	<	XX
cord-006860-a3b8hyyr	609	42	dog	dog	NNP
cord-006860-a3b8hyyr	609	43	<	<	XX
cord-006860-a3b8hyyr	609	44	rabbit	rabbit	NNP
cord-006860-a3b8hyyr	609	45	.	.	.
cord-006860-a3b8hyyr	610	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	610	2	assume	assume	VBP
cord-006860-a3b8hyyr	610	3	that	that	IN
cord-006860-a3b8hyyr	610	4	this	this	DT
cord-006860-a3b8hyyr	610	5	effect	effect	NN
cord-006860-a3b8hyyr	610	6	is	be	VBZ
cord-006860-a3b8hyyr	610	7	mainly	mainly	RB
cord-006860-a3b8hyyr	610	8	caused	cause	VBN
cord-006860-a3b8hyyr	610	9	by	by	IN
cord-006860-a3b8hyyr	610	10	differences	difference	NNS
cord-006860-a3b8hyyr	610	11	in	in	IN
cord-006860-a3b8hyyr	610	12	the	the	DT
cord-006860-a3b8hyyr	610	13	APC	APC	NNP
cord-006860-a3b8hyyr	610	14	cleavage	cleavage	NN
cord-006860-a3b8hyyr	610	15	region	region	NN
cord-006860-a3b8hyyr	610	16	of	of	IN
cord-006860-a3b8hyyr	610	17	factor	factor	NN
cord-006860-a3b8hyyr	610	18	V	v	NN
cord-006860-a3b8hyyr	610	19	,	,	,
cord-006860-a3b8hyyr	610	20	as	as	IN
cord-006860-a3b8hyyr	610	21	recently	recently	RB
cord-006860-a3b8hyyr	610	22	described	describe	VBN
cord-006860-a3b8hyyr	610	23	for	for	IN
cord-006860-a3b8hyyr	610	24	a	a	DT
cord-006860-a3b8hyyr	610	25	factor	factor	NN
cord-006860-a3b8hyyr	610	26	V	v	NN
cord-006860-a3b8hyyr	610	27	mutation	mutation	NN
cord-006860-a3b8hyyr	610	28	in	in	IN
cord-006860-a3b8hyyr	610	29	bumat	bumat	NNP
cord-006860-a3b8hyyr	610	30	~	~	NFP
cord-006860-a3b8hyyr	610	31	s	s	NN
cord-006860-a3b8hyyr	610	32	:	:	:
cord-006860-a3b8hyyr	610	33	factor	factor	NN
cord-006860-a3b8hyyr	610	34	V	V	NNP
cord-006860-a3b8hyyr	610	35	-	-	HYPH
cord-006860-a3b8hyyr	610	36	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	610	37	.	.	.
cord-006860-a3b8hyyr	611	1	This	this	DT
cord-006860-a3b8hyyr	611	2	was	be	VBD
cord-006860-a3b8hyyr	611	3	corroborated	corroborate	VBN
cord-006860-a3b8hyyr	611	4	by	by	IN
cord-006860-a3b8hyyr	611	5	the	the	DT
cord-006860-a3b8hyyr	611	6	finding	finding	NN
cord-006860-a3b8hyyr	611	7	that	that	DT
cord-006860-a3b8hyyr	611	8	addition	addition	NN
cord-006860-a3b8hyyr	611	9	of	of	IN
cord-006860-a3b8hyyr	611	10	human	human	JJ
cord-006860-a3b8hyyr	611	11	factor	factor	NN
cord-006860-a3b8hyyr	611	12	V	V	NNP
cord-006860-a3b8hyyr	611	13	similar	similar	JJ
cord-006860-a3b8hyyr	611	14	to	to	IN
cord-006860-a3b8hyyr	611	15	the	the	DT
cord-006860-a3b8hyyr	611	16	factor	factor	NN
cord-006860-a3b8hyyr	611	17	V	v	NN
cord-006860-a3b8hyyr	611	18	added	add	VBD
cord-006860-a3b8hyyr	611	19	with	with	IN
cord-006860-a3b8hyyr	611	20	the	the	DT
cord-006860-a3b8hyyr	611	21	animal	animal	NN
cord-006860-a3b8hyyr	611	22	plasma	plasma	NN
cord-006860-a3b8hyyr	611	23	had	have	VBD
cord-006860-a3b8hyyr	611	24	only	only	JJ
cord-006860-a3b8hyyr	611	25	minor	minor	JJ
cord-006860-a3b8hyyr	611	26	influence	influence	NN
cord-006860-a3b8hyyr	611	27	on	on	IN
cord-006860-a3b8hyyr	611	28	test	test	NN
cord-006860-a3b8hyyr	611	29	outcome	outcome	NN
cord-006860-a3b8hyyr	611	30	.	.	.
cord-006860-a3b8hyyr	612	1	Coagulation	coagulation	NN
cord-006860-a3b8hyyr	612	2	assays	assay	NNS
cord-006860-a3b8hyyr	612	3	dependent	dependent	JJ
cord-006860-a3b8hyyr	612	4	on	on	IN
cord-006860-a3b8hyyr	612	5	APC	APC	NNP
cord-006860-a3b8hyyr	612	6	,	,	,
cord-006860-a3b8hyyr	612	7	such	such	JJ
cord-006860-a3b8hyyr	612	8	as	as	IN
cord-006860-a3b8hyyr	612	9	for	for	IN
cord-006860-a3b8hyyr	612	10	protein	protein	NN
cord-006860-a3b8hyyr	612	11	C	c	NN
cord-006860-a3b8hyyr	612	12	and	and	CC
cord-006860-a3b8hyyr	612	13	protein	protein	NN
cord-006860-a3b8hyyr	612	14	S	S	NNP
cord-006860-a3b8hyyr	612	15	determination	determination	NN
cord-006860-a3b8hyyr	612	16	,	,	,
cord-006860-a3b8hyyr	612	17	in	in	IN
cord-006860-a3b8hyyr	612	18	the	the	DT
cord-006860-a3b8hyyr	612	19	standard	standard	JJ
cord-006860-a3b8hyyr	612	20	APC	APC	NNP
cord-006860-a3b8hyyr	612	21	assay	assay	NN
cord-006860-a3b8hyyr	612	22	,	,	,
cord-006860-a3b8hyyr	612	23	the	the	DT
cord-006860-a3b8hyyr	612	24	more	more	JJR
cord-006860-a3b8hyyr	612	25	factor	factor	NN
cord-006860-a3b8hyyr	612	26	V	V	NNP
cord-006860-a3b8hyyr	612	27	-	-	HYPH
cord-006860-a3b8hyyr	612	28	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	612	29	specific	specific	JJ
cord-006860-a3b8hyyr	612	30	APC	APC	NNP
cord-006860-a3b8hyyr	612	31	assay	assay	NN
cord-006860-a3b8hyyr	612	32	and	and	CC
cord-006860-a3b8hyyr	612	33	in	in	IN
cord-006860-a3b8hyyr	612	34	the	the	DT
cord-006860-a3b8hyyr	612	35	PCAT	PCAT	NNP
cord-006860-a3b8hyyr	612	36	,	,	,
cord-006860-a3b8hyyr	612	37	a	a	DT
cord-006860-a3b8hyyr	612	38	new	new	JJ
cord-006860-a3b8hyyr	612	39	screening	screening	NN
cord-006860-a3b8hyyr	612	40	assay	assay	NN
cord-006860-a3b8hyyr	612	41	for	for	IN
cord-006860-a3b8hyyr	612	42	the	the	DT
cord-006860-a3b8hyyr	612	43	whole	whole	JJ
cord-006860-a3b8hyyr	612	44	protein	protein	NN
cord-006860-a3b8hyyr	612	45	C	c	NN
cord-006860-a3b8hyyr	612	46	system	system	NN
cord-006860-a3b8hyyr	612	47	,	,	,
cord-006860-a3b8hyyr	612	48	are	be	VBP
cord-006860-a3b8hyyr	612	49	based	base	VBN
cord-006860-a3b8hyyr	612	50	on	on	IN
cord-006860-a3b8hyyr	612	51	the	the	DT
cord-006860-a3b8hyyr	612	52	inactivation	inactivation	NN
cord-006860-a3b8hyyr	612	53	of	of	IN
cord-006860-a3b8hyyr	612	54	factor	factor	NN
cord-006860-a3b8hyyr	612	55	Va	Va	NNP
cord-006860-a3b8hyyr	612	56	via	via	IN
cord-006860-a3b8hyyr	612	57	APC	APC	NNP
cord-006860-a3b8hyyr	612	58	.	.	.
cord-006860-a3b8hyyr	613	1	Thus	thus	RB
cord-006860-a3b8hyyr	613	2	,	,	,
cord-006860-a3b8hyyr	613	3	in	in	IN
cord-006860-a3b8hyyr	613	4	all	all	PDT
cord-006860-a3b8hyyr	613	5	these	these	DT
cord-006860-a3b8hyyr	613	6	assays	assay	NNS
cord-006860-a3b8hyyr	613	7	,	,	,
cord-006860-a3b8hyyr	613	8	5	5	CD
cord-006860-a3b8hyyr	613	9	%	%	NN
cord-006860-a3b8hyyr	613	10	of	of	IN
cord-006860-a3b8hyyr	613	11	rabbit	rabbit	NN
cord-006860-a3b8hyyr	613	12	plasma	plasma	NN
cord-006860-a3b8hyyr	613	13	added	add	VBN
cord-006860-a3b8hyyr	613	14	to	to	IN
cord-006860-a3b8hyyr	613	15	human	human	JJ
cord-006860-a3b8hyyr	613	16	plasma	plasma	NN
cord-006860-a3b8hyyr	613	17	mimicked	mimic	VBD
cord-006860-a3b8hyyr	613	18	a	a	DT
cord-006860-a3b8hyyr	613	19	APC	APC	NNP
cord-006860-a3b8hyyr	613	20	response	response	NN
cord-006860-a3b8hyyr	613	21	as	as	IN
cord-006860-a3b8hyyr	613	22	observed	observe	VBN
cord-006860-a3b8hyyr	613	23	for	for	IN
cord-006860-a3b8hyyr	613	24	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	613	25	carriers	carrier	NNS
cord-006860-a3b8hyyr	613	26	of	of	IN
cord-006860-a3b8hyyr	613	27	factor	factor	NN
cord-006860-a3b8hyyr	613	28	V	V	NNP
cord-006860-a3b8hyyr	613	29	-	-	HYPH
cord-006860-a3b8hyyr	613	30	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	613	31	and	and	CC
cord-006860-a3b8hyyr	613	32	20	20	CD
cord-006860-a3b8hyyr	613	33	%	%	NN
cord-006860-a3b8hyyr	613	34	as	as	IN
cord-006860-a3b8hyyr	613	35	for	for	IN
cord-006860-a3b8hyyr	613	36	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	613	37	carriers	carrier	NNS
cord-006860-a3b8hyyr	613	38	.	.	.
cord-006860-a3b8hyyr	614	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	614	2	exploited	exploit	VBD
cord-006860-a3b8hyyr	614	3	this	this	DT
cord-006860-a3b8hyyr	614	4	factor	factor	NN
cord-006860-a3b8hyyr	614	5	V	V	NNP
cord-006860-a3b8hyyr	614	6	-	-	HYPH
cord-006860-a3b8hyyr	614	7	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	614	8	like	like	IN
cord-006860-a3b8hyyr	614	9	behaviour	behaviour	NN
cord-006860-a3b8hyyr	614	10	to	to	TO
cord-006860-a3b8hyyr	614	11	prepare	prepare	VB
cord-006860-a3b8hyyr	614	12	plasma	plasma	NN
cord-006860-a3b8hyyr	614	13	standards	standard	NNS
cord-006860-a3b8hyyr	614	14	for	for	IN
cord-006860-a3b8hyyr	614	15	calibration	calibration	NN
cord-006860-a3b8hyyr	614	16	of	of	IN
cord-006860-a3b8hyyr	614	17	APC	APC	NNP
cord-006860-a3b8hyyr	614	18	dependent	dependent	JJ
cord-006860-a3b8hyyr	614	19	assays	assay	NNS
cord-006860-a3b8hyyr	614	20	by	by	IN
cord-006860-a3b8hyyr	614	21	mixing	mix	VBG
cord-006860-a3b8hyyr	614	22	rabbit	rabbit	NN
cord-006860-a3b8hyyr	614	23	plasma	plasma	NN
cord-006860-a3b8hyyr	614	24	with	with	IN
cord-006860-a3b8hyyr	614	25	human	human	JJ
cord-006860-a3b8hyyr	614	26	plasma~	plasma~	NN
cord-006860-a3b8hyyr	615	1	As	as	IN
cord-006860-a3b8hyyr	615	2	reference	reference	NN
cord-006860-a3b8hyyr	615	3	for	for	IN
cord-006860-a3b8hyyr	615	4	these	these	DT
cord-006860-a3b8hyyr	615	5	standards	standard	NNS
cord-006860-a3b8hyyr	615	6	the	the	DT
cord-006860-a3b8hyyr	615	7	0	0	CD
cord-006860-a3b8hyyr	615	8	%	%	NN
cord-006860-a3b8hyyr	615	9	value	value	NN
cord-006860-a3b8hyyr	615	10	was	be	VBD
cord-006860-a3b8hyyr	615	11	assigned	assign	VBN
cord-006860-a3b8hyyr	615	12	to	to	IN
cord-006860-a3b8hyyr	615	13	the	the	DT
cord-006860-a3b8hyyr	615	14	clotting	clotting	NN
cord-006860-a3b8hyyr	615	15	time	time	NN
cord-006860-a3b8hyyr	615	16	in	in	IN
cord-006860-a3b8hyyr	615	17	the	the	DT
cord-006860-a3b8hyyr	615	18	absence	absence	NN
cord-006860-a3b8hyyr	615	19	of	of	IN
cord-006860-a3b8hyyr	615	20	APC	APC	NNP
cord-006860-a3b8hyyr	615	21	,	,	,
cord-006860-a3b8hyyr	615	22	while	while	IN
cord-006860-a3b8hyyr	615	23	the	the	DT
cord-006860-a3b8hyyr	615	24	100	100	CD
cord-006860-a3b8hyyr	615	25	%	%	NN
cord-006860-a3b8hyyr	615	26	value	value	NN
cord-006860-a3b8hyyr	615	27	was	be	VBD
cord-006860-a3b8hyyr	615	28	assigned	assign	VBN
cord-006860-a3b8hyyr	615	29	to	to	IN
cord-006860-a3b8hyyr	615	30	the	the	DT
cord-006860-a3b8hyyr	615	31	clotting	clotting	NN
cord-006860-a3b8hyyr	615	32	time	time	NN
cord-006860-a3b8hyyr	615	33	in	in	IN
cord-006860-a3b8hyyr	615	34	presence	presence	NN
cord-006860-a3b8hyyr	615	35	of	of	IN
cord-006860-a3b8hyyr	615	36	APC	APC	NNP
cord-006860-a3b8hyyr	615	37	as	as	IN
cord-006860-a3b8hyyr	615	38	obtained	obtain	VBN
cord-006860-a3b8hyyr	615	39	with	with	IN
cord-006860-a3b8hyyr	615	40	a	a	DT
cord-006860-a3b8hyyr	615	41	human	human	JJ
cord-006860-a3b8hyyr	615	42	,	,	,
cord-006860-a3b8hyyr	615	43	normal	normal	JJ
cord-006860-a3b8hyyr	615	44	plasma	plasma	NN
cord-006860-a3b8hyyr	615	45	pool	pool	NN
cord-006860-a3b8hyyr	615	46	.	.	.
cord-006860-a3b8hyyr	616	1	Then	then	RB
cord-006860-a3b8hyyr	616	2	these	these	DT
cord-006860-a3b8hyyr	616	3	calibrated	calibrate	VBN
cord-006860-a3b8hyyr	616	4	standards	standard	NNS
cord-006860-a3b8hyyr	616	5	were	be	VBD
cord-006860-a3b8hyyr	616	6	used	use	VBN
cord-006860-a3b8hyyr	616	7	for	for	IN
cord-006860-a3b8hyyr	616	8	establishing	establish	VBG
cord-006860-a3b8hyyr	616	9	reference	reference	NN
cord-006860-a3b8hyyr	616	10	curves	curve	NNS
cord-006860-a3b8hyyr	616	11	.	.	.
cord-006860-a3b8hyyr	617	1	On	on	IN
cord-006860-a3b8hyyr	617	2	automated	automated	JJ
cord-006860-a3b8hyyr	617	3	coagulation	coagulation	NN
cord-006860-a3b8hyyr	617	4	analyzers	analyzer	NNS
cord-006860-a3b8hyyr	617	5	,	,	,
cord-006860-a3b8hyyr	617	6	the	the	DT
cord-006860-a3b8hyyr	617	7	results	result	NNS
cord-006860-a3b8hyyr	617	8	obtained	obtain	VBN
cord-006860-a3b8hyyr	617	9	were	be	VBD
cord-006860-a3b8hyyr	617	10	automatically	automatically	RB
cord-006860-a3b8hyyr	617	11	reported	report	VBN
cord-006860-a3b8hyyr	617	12	in	in	IN
cord-006860-a3b8hyyr	617	13	'	'	CD
cord-006860-a3b8hyyr	617	14	%	%	NN
cord-006860-a3b8hyyr	617	15	of	of	IN
cord-006860-a3b8hyyr	617	16	normal	normal	JJ
cord-006860-a3b8hyyr	617	17	'	'	''
cord-006860-a3b8hyyr	617	18	or	or	CC
cord-006860-a3b8hyyr	617	19	'	'	''
cord-006860-a3b8hyyr	617	20	%	%	NN
cord-006860-a3b8hyyr	618	1	sensitivity'•	sensitivity'•	NNP
cord-006860-a3b8hyyr	619	1	This	this	DT
cord-006860-a3b8hyyr	619	2	not	not	RB
cord-006860-a3b8hyyr	619	3	only	only	RB
cord-006860-a3b8hyyr	619	4	eases	ease	VBZ
cord-006860-a3b8hyyr	619	5	evaluation	evaluation	NN
cord-006860-a3b8hyyr	619	6	,	,	,
cord-006860-a3b8hyyr	619	7	more	more	RBR
cord-006860-a3b8hyyr	619	8	importantly	importantly	RB
cord-006860-a3b8hyyr	619	9	,	,	,
cord-006860-a3b8hyyr	619	10	this	this	DT
cord-006860-a3b8hyyr	619	11	procedure	procedure	NN
cord-006860-a3b8hyyr	619	12	also	also	RB
cord-006860-a3b8hyyr	619	13	considerably	considerably	RB
cord-006860-a3b8hyyr	619	14	improves	improve	VBZ
cord-006860-a3b8hyyr	619	15	the	the	DT
cord-006860-a3b8hyyr	619	16	comparability	comparability	NN
cord-006860-a3b8hyyr	619	17	of	of	IN
cord-006860-a3b8hyyr	619	18	results	result	NNS
cord-006860-a3b8hyyr	619	19	obtained	obtain	VBN
cord-006860-a3b8hyyr	619	20	with	with	IN
cord-006860-a3b8hyyr	619	21	different	different	JJ
cord-006860-a3b8hyyr	619	22	reagents	reagent	NNS
cord-006860-a3b8hyyr	619	23	and	and	CC
cord-006860-a3b8hyyr	619	24	instruments	instrument	NNS
cord-006860-a3b8hyyr	619	25	.	.	.
cord-006860-a3b8hyyr	620	1	In	in	IN
cord-006860-a3b8hyyr	620	2	order	order	NN
cord-006860-a3b8hyyr	620	3	to	to	TO
cord-006860-a3b8hyyr	620	4	establish	establish	VB
cord-006860-a3b8hyyr	620	5	the	the	DT
cord-006860-a3b8hyyr	620	6	methods	method	NNS
cord-006860-a3b8hyyr	620	7	for	for	IN
cord-006860-a3b8hyyr	620	8	activated	activate	VBN
cord-006860-a3b8hyyr	620	9	protein	protein	NN
cord-006860-a3b8hyyr	620	10	C	c	NN
cord-006860-a3b8hyyr	620	11	resistance	resistance	NN
cord-006860-a3b8hyyr	620	12	and	and	CC
cord-006860-a3b8hyyr	620	13	the	the	DT
cord-006860-a3b8hyyr	620	14	Faktor	Faktor	NNP
cord-006860-a3b8hyyr	620	15	V	V	NNP
cord-006860-a3b8hyyr	620	16	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	620	17	-	-	HYPH
cord-006860-a3b8hyyr	620	18	Mutation	Mutation	NNP
cord-006860-a3b8hyyr	620	19	we	-PRON-	PRP
cord-006860-a3b8hyyr	620	20	investigated	investigate	VBD
cord-006860-a3b8hyyr	620	21	204	204	CD
cord-006860-a3b8hyyr	620	22	healthy	healthy	JJ
cord-006860-a3b8hyyr	620	23	individuals	individual	NNS
cord-006860-a3b8hyyr	620	24	(	(	-LRB-
cord-006860-a3b8hyyr	620	25	128	128	CD
cord-006860-a3b8hyyr	620	26	women	woman	NNS
cord-006860-a3b8hyyr	620	27	,	,	,
cord-006860-a3b8hyyr	620	28	76	76	CD
cord-006860-a3b8hyyr	620	29	men	man	NNS
cord-006860-a3b8hyyr	620	30	,	,	,
cord-006860-a3b8hyyr	620	31	median	median	NN
cord-006860-a3b8hyyr	620	32	age	age	NN
cord-006860-a3b8hyyr	620	33	37	37	CD
cord-006860-a3b8hyyr	620	34	ys	y	NNS
cord-006860-a3b8hyyr	620	35	)	)	-RRB-
cord-006860-a3b8hyyr	620	36	using	use	VBG
cord-006860-a3b8hyyr	620	37	the	the	DT
cord-006860-a3b8hyyr	620	38	assay	assay	NN
cord-006860-a3b8hyyr	620	39	"	"	``
cord-006860-a3b8hyyr	620	40	Contest	contest	NN
cord-006860-a3b8hyyr	620	41	®	®	NNP
cord-006860-a3b8hyyr	620	42	APC	APC	NNP
cord-006860-a3b8hyyr	620	43	-	-	HYPH
cord-006860-a3b8hyyr	620	44	resistance	resistance	NN
cord-006860-a3b8hyyr	620	45	"	"	''
cord-006860-a3b8hyyr	620	46	(	(	-LRB-
cord-006860-a3b8hyyr	620	47	Chromogenix	Chromogenix	NNP
cord-006860-a3b8hyyr	620	48	,	,	,
cord-006860-a3b8hyyr	620	49	Sweden	Sweden	NNP
cord-006860-a3b8hyyr	620	50	)	)	-RRB-
cord-006860-a3b8hyyr	620	51	.	.	.
cord-006860-a3b8hyyr	621	1	The	the	DT
cord-006860-a3b8hyyr	621	2	mean	mean	JJ
cord-006860-a3b8hyyr	621	3	APC	APC	NNP
cord-006860-a3b8hyyr	621	4	-	-	HYPH
cord-006860-a3b8hyyr	621	5	ratio	ratio	NN
cord-006860-a3b8hyyr	621	6	was	be	VBD
cord-006860-a3b8hyyr	621	7	2.65	2.65	CD
cord-006860-a3b8hyyr	621	8	,	,	,
cord-006860-a3b8hyyr	621	9	the	the	DT
cord-006860-a3b8hyyr	621	10	cut	cut	VBN
cord-006860-a3b8hyyr	621	11	-	-	HYPH
cord-006860-a3b8hyyr	621	12	off	off	RP
cord-006860-a3b8hyyr	621	13	level	level	NN
cord-006860-a3b8hyyr	621	14	for	for	IN
cord-006860-a3b8hyyr	621	15	low	low	JJ
cord-006860-a3b8hyyr	621	16	response	response	NN
cord-006860-a3b8hyyr	621	17	to	to	IN
cord-006860-a3b8hyyr	621	18	APC	APC	NNP
cord-006860-a3b8hyyr	621	19	was	be	VBD
cord-006860-a3b8hyyr	621	20	calculated	calculate	VBN
cord-006860-a3b8hyyr	621	21	as	as	IN
cord-006860-a3b8hyyr	621	22	2.15	2.15	CD
cord-006860-a3b8hyyr	621	23	,	,	,
cord-006860-a3b8hyyr	621	24	46/128	46/128	CD
cord-006860-a3b8hyyr	621	25	women	woman	NNS
cord-006860-a3b8hyyr	621	26	were	be	VBD
cord-006860-a3b8hyyr	621	27	oral	oral	JJ
cord-006860-a3b8hyyr	621	28	-	-	HYPH
cord-006860-a3b8hyyr	621	29	contraceptive	contraceptive	JJ
cord-006860-a3b8hyyr	621	30	users	user	NNS
cord-006860-a3b8hyyr	621	31	.	.	.
cord-006860-a3b8hyyr	622	1	They	-PRON-	PRP
cord-006860-a3b8hyyr	622	2	showed	show	VBD
cord-006860-a3b8hyyr	622	3	a	a	DT
cord-006860-a3b8hyyr	622	4	slight	slight	JJ
cord-006860-a3b8hyyr	622	5	decreased	decrease	VBN
cord-006860-a3b8hyyr	622	6	APC	APC	NNP
cord-006860-a3b8hyyr	622	7	-	-	HYPH
cord-006860-a3b8hyyr	622	8	ratio	ratio	NN
cord-006860-a3b8hyyr	622	9	(	(	-LRB-
cord-006860-a3b8hyyr	622	10	mean	mean	VB
cord-006860-a3b8hyyr	622	11	2.46	2.46	CD
cord-006860-a3b8hyyr	622	12	)	)	-RRB-
cord-006860-a3b8hyyr	622	13	.	.	.
cord-006860-a3b8hyyr	623	1	24	24	CD
cord-006860-a3b8hyyr	623	2	of	of	IN
cord-006860-a3b8hyyr	623	3	the	the	DT
cord-006860-a3b8hyyr	623	4	204	204	CD
cord-006860-a3b8hyyr	623	5	individuals	individual	NNS
cord-006860-a3b8hyyr	623	6	(	(	-LRB-
cord-006860-a3b8hyyr	623	7	11,8	11,8	CD
cord-006860-a3b8hyyr	623	8	%	%	NN
cord-006860-a3b8hyyr	623	9	)	)	-RRB-
cord-006860-a3b8hyyr	623	10	had	have	VBD
cord-006860-a3b8hyyr	623	11	a	a	DT
cord-006860-a3b8hyyr	623	12	poor	poor	JJ
cord-006860-a3b8hyyr	623	13	response	response	NN
cord-006860-a3b8hyyr	623	14	to	to	IN
cord-006860-a3b8hyyr	623	15	APC	APC	NNP
cord-006860-a3b8hyyr	623	16	(	(	-LRB-
cord-006860-a3b8hyyr	623	17	mean	mean	JJ
cord-006860-a3b8hyyr	623	18	ratio	ratio	NN
cord-006860-a3b8hyyr	623	19	1.94	1.94	CD
cord-006860-a3b8hyyr	623	20	)	)	-RRB-
cord-006860-a3b8hyyr	623	21	as	as	IN
cord-006860-a3b8hyyr	623	22	a	a	DT
cord-006860-a3b8hyyr	623	23	APC	APC	NNP
cord-006860-a3b8hyyr	623	24	-	-	HYPH
cord-006860-a3b8hyyr	623	25	resistance	resistance	NN
cord-006860-a3b8hyyr	623	26	.	.	.
cord-006860-a3b8hyyr	624	1	For	for	IN
cord-006860-a3b8hyyr	624	2	detecting	detect	VBG
cord-006860-a3b8hyyr	624	3	the	the	DT
cord-006860-a3b8hyyr	624	4	factor	factor	NN
cord-006860-a3b8hyyr	624	5	V	v	NN
cord-006860-a3b8hyyr	624	6	gene	gene	NN
cord-006860-a3b8hyyr	624	7	mutation	mutation	NN
cord-006860-a3b8hyyr	624	8	we	-PRON-	PRP
cord-006860-a3b8hyyr	624	9	a	a	DT
cord-006860-a3b8hyyr	624	10	used	use	VBN
cord-006860-a3b8hyyr	624	11	non	non	JJ
cord-006860-a3b8hyyr	624	12	commercial	commercial	JJ
cord-006860-a3b8hyyr	624	13	own	own	JJ
cord-006860-a3b8hyyr	624	14	modified	modify	VBN
cord-006860-a3b8hyyr	624	15	easy	easy	RB
cord-006860-a3b8hyyr	624	16	to	to	TO
cord-006860-a3b8hyyr	624	17	handle	handle	VB
cord-006860-a3b8hyyr	624	18	PCR	PCR	NNP
cord-006860-a3b8hyyr	624	19	-	-	HYPH
cord-006860-a3b8hyyr	624	20	based	base	VBN
cord-006860-a3b8hyyr	624	21	test	test	NN
cord-006860-a3b8hyyr	624	22	.	.	.
cord-006860-a3b8hyyr	625	1	In	in	IN
cord-006860-a3b8hyyr	625	2	14	14	CD
cord-006860-a3b8hyyr	625	3	of	of	IN
cord-006860-a3b8hyyr	625	4	the	the	DT
cord-006860-a3b8hyyr	625	5	204	204	CD
cord-006860-a3b8hyyr	625	6	individuals	individual	NNS
cord-006860-a3b8hyyr	625	7	(	(	-LRB-
cord-006860-a3b8hyyr	625	8	6.9	6.9	CD
cord-006860-a3b8hyyr	625	9	%	%	NN
cord-006860-a3b8hyyr	625	10	)	)	-RRB-
cord-006860-a3b8hyyr	625	11	the	the	DT
cord-006860-a3b8hyyr	625	12	factor	factor	NN
cord-006860-a3b8hyyr	625	13	V	V	NNP
cord-006860-a3b8hyyr	625	14	-	-	HYPH
cord-006860-a3b8hyyr	625	15	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	625	16	mutation	mutation	NN
cord-006860-a3b8hyyr	625	17	could	could	MD
cord-006860-a3b8hyyr	625	18	be	be	VB
cord-006860-a3b8hyyr	625	19	found	find	VBN
cord-006860-a3b8hyyr	625	20	as	as	IN
cord-006860-a3b8hyyr	625	21	heterozygotes	heterozygote	NNS
cord-006860-a3b8hyyr	625	22	.	.	.
cord-006860-a3b8hyyr	626	1	In	in	IN
cord-006860-a3b8hyyr	626	2	this	this	DT
cord-006860-a3b8hyyr	626	3	group	group	NN
cord-006860-a3b8hyyr	626	4	,	,	,
cord-006860-a3b8hyyr	626	5	the	the	DT
cord-006860-a3b8hyyr	626	6	APC	APC	NNP
cord-006860-a3b8hyyr	626	7	-	-	HYPH
cord-006860-a3b8hyyr	626	8	ratio	ratio	NN
cord-006860-a3b8hyyr	626	9	was	be	VBD
cord-006860-a3b8hyyr	626	10	significant	significant	JJ
cord-006860-a3b8hyyr	626	11	lower	lower	RBR
cord-006860-a3b8hyyr	626	12	(	(	-LRB-
cord-006860-a3b8hyyr	626	13	mean	mean	VB
cord-006860-a3b8hyyr	626	14	1.87	1.87	CD
cord-006860-a3b8hyyr	626	15	)	)	-RRB-
cord-006860-a3b8hyyr	626	16	as	as	IN
cord-006860-a3b8hyyr	626	17	in	in	IN
cord-006860-a3b8hyyr	626	18	the	the	DT
cord-006860-a3b8hyyr	626	19	group	group	NN
cord-006860-a3b8hyyr	626	20	with	with	IN
cord-006860-a3b8hyyr	626	21	APC	APC	NNP
cord-006860-a3b8hyyr	626	22	-	-	HYPH
cord-006860-a3b8hyyr	626	23	resistanee	resistanee	NNP
cord-006860-a3b8hyyr	626	24	and	and	CC
cord-006860-a3b8hyyr	626	25	without	without	IN
cord-006860-a3b8hyyr	626	26	deteetiun	deteetiun	NNP
cord-006860-a3b8hyyr	626	27	of	of	IN
cord-006860-a3b8hyyr	626	28	the	the	DT
cord-006860-a3b8hyyr	626	29	factor	factor	NN
cord-006860-a3b8hyyr	626	30	V	v	NN
cord-006860-a3b8hyyr	626	31	mutation	mutation	NN
cord-006860-a3b8hyyr	626	32	(	(	-LRB-
cord-006860-a3b8hyyr	626	33	mean	mean	VB
cord-006860-a3b8hyyr	626	34	2.04	2.04	CD
cord-006860-a3b8hyyr	626	35	)	)	-RRB-
cord-006860-a3b8hyyr	626	36	.	.	.
cord-006860-a3b8hyyr	627	1	Nevertheless	nevertheless	RB
cord-006860-a3b8hyyr	627	2	in	in	IN
cord-006860-a3b8hyyr	627	3	one	one	CD
cord-006860-a3b8hyyr	627	4	individual	individual	NN
cord-006860-a3b8hyyr	627	5	with	with	IN
cord-006860-a3b8hyyr	627	6	beterozygote	beterozygote	NNP
cord-006860-a3b8hyyr	627	7	factor	factor	NN
cord-006860-a3b8hyyr	627	8	V	V	NNP
cord-006860-a3b8hyyr	627	9	-	-	HYPH
cord-006860-a3b8hyyr	627	10	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	627	11	,	,	,
cord-006860-a3b8hyyr	627	12	the	the	DT
cord-006860-a3b8hyyr	627	13	APC	APC	NNP
cord-006860-a3b8hyyr	627	14	-	-	HYPH
cord-006860-a3b8hyyr	627	15	ratio	ratio	NN
cord-006860-a3b8hyyr	627	16	was	be	VBD
cord-006860-a3b8hyyr	627	17	found	find	VBN
cord-006860-a3b8hyyr	627	18	in	in	IN
cord-006860-a3b8hyyr	627	19	the	the	DT
cord-006860-a3b8hyyr	627	20	normal	normal	JJ
cord-006860-a3b8hyyr	627	21	range	range	NN
cord-006860-a3b8hyyr	627	22	(	(	-LRB-
cord-006860-a3b8hyyr	627	23	2.24	2.24	CD
cord-006860-a3b8hyyr	627	24	)	)	-RRB-
cord-006860-a3b8hyyr	627	25	,	,	,
cord-006860-a3b8hyyr	627	26	also	also	RB
cord-006860-a3b8hyyr	627	27	in	in	IN
cord-006860-a3b8hyyr	627	28	a	a	DT
cord-006860-a3b8hyyr	627	29	few	few	JJ
cord-006860-a3b8hyyr	627	30	individuals	individual	NNS
cord-006860-a3b8hyyr	627	31	with	with	IN
cord-006860-a3b8hyyr	627	32	very	very	RB
cord-006860-a3b8hyyr	627	33	iow	iow	NNP
cord-006860-a3b8hyyr	627	34	APC	APC	NNP
cord-006860-a3b8hyyr	627	35	-	-	HYPH
cord-006860-a3b8hyyr	627	36	ratio	ratio	NN
cord-006860-a3b8hyyr	627	37	the	the	DT
cord-006860-a3b8hyyr	627	38	factor	factor	NN
cord-006860-a3b8hyyr	627	39	V	v	NN
cord-006860-a3b8hyyr	627	40	mutation	mutation	NN
cord-006860-a3b8hyyr	627	41	could	could	MD
cord-006860-a3b8hyyr	627	42	not	not	RB
cord-006860-a3b8hyyr	627	43	he	-PRON-	PRP
cord-006860-a3b8hyyr	627	44	detected	detect	VBD
cord-006860-a3b8hyyr	627	45	.	.	.
cord-006860-a3b8hyyr	628	1	Finally	finally	RB
cord-006860-a3b8hyyr	628	2	this	this	DT
cord-006860-a3b8hyyr	628	3	data	data	NN
cord-006860-a3b8hyyr	628	4	suggests	suggest	VBZ
cord-006860-a3b8hyyr	628	5	a	a	DT
cord-006860-a3b8hyyr	628	6	high	high	JJ
cord-006860-a3b8hyyr	628	7	prevalence	prevalence	NN
cord-006860-a3b8hyyr	628	8	of	of	IN
cord-006860-a3b8hyyr	628	9	APC	apc	NN
cord-006860-a3b8hyyr	628	10	-	-	HYPH
cord-006860-a3b8hyyr	628	11	resistance	resistance	NN
cord-006860-a3b8hyyr	628	12	and	and	CC
cord-006860-a3b8hyyr	628	13	factor	factor	NN
cord-006860-a3b8hyyr	628	14	V	V	NNP
cord-006860-a3b8hyyr	628	15	-	-	HYPH
cord-006860-a3b8hyyr	628	16	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	628	17	mutation	mutation	NN
cord-006860-a3b8hyyr	628	18	in	in	IN
cord-006860-a3b8hyyr	628	19	the	the	DT
cord-006860-a3b8hyyr	628	20	population	population	NN
cord-006860-a3b8hyyr	628	21	of	of	IN
cord-006860-a3b8hyyr	628	22	the	the	DT
cord-006860-a3b8hyyr	628	23	southwest	southwest	NN
cord-006860-a3b8hyyr	628	24	of	of	IN
cord-006860-a3b8hyyr	628	25	Germany	Germany	NNP
cord-006860-a3b8hyyr	628	26	.	.	.
cord-006860-a3b8hyyr	629	1	Resistance	resistance	NN
cord-006860-a3b8hyyr	629	2	to	to	IN
cord-006860-a3b8hyyr	629	3	activated	activate	VBN
cord-006860-a3b8hyyr	629	4	protein	protein	NN
cord-006860-a3b8hyyr	629	5	C	C	NNP
cord-006860-a3b8hyyr	629	6	(	(	-LRB-
cord-006860-a3b8hyyr	629	7	APC	APC	NNP
cord-006860-a3b8hyyr	629	8	)	)	-RRB-
cord-006860-a3b8hyyr	629	9	has	have	VBZ
cord-006860-a3b8hyyr	629	10	been	be	VBN
cord-006860-a3b8hyyr	629	11	reported	report	VBN
cord-006860-a3b8hyyr	629	12	to	to	TO
cord-006860-a3b8hyyr	629	13	interfere	interfere	VB
cord-006860-a3b8hyyr	629	14	in	in	IN
cord-006860-a3b8hyyr	629	15	clotting	clotting	NN
cord-006860-a3b8hyyr	629	16	assays	assay	NNS
cord-006860-a3b8hyyr	629	17	for	for	IN
cord-006860-a3b8hyyr	629	18	protein	protein	NN
cord-006860-a3b8hyyr	629	19	C	C	NNP
cord-006860-a3b8hyyr	629	20	(	(	-LRB-
cord-006860-a3b8hyyr	629	21	PC	PC	NNP
cord-006860-a3b8hyyr	629	22	)	)	-RRB-
cord-006860-a3b8hyyr	629	23	and	and	CC
cord-006860-a3b8hyyr	629	24	protein	protein	NN
cord-006860-a3b8hyyr	629	25	S	S	NNP
cord-006860-a3b8hyyr	629	26	(	(	-LRB-
cord-006860-a3b8hyyr	629	27	PS	PS	NNP
cord-006860-a3b8hyyr	629	28	)	)	-RRB-
cord-006860-a3b8hyyr	629	29	from	from	IN
cord-006860-a3b8hyyr	629	30	various	various	JJ
cord-006860-a3b8hyyr	629	31	manufacturers	manufacturer	NNS
cord-006860-a3b8hyyr	629	32	,	,	,
cord-006860-a3b8hyyr	629	33	resulting	result	VBG
cord-006860-a3b8hyyr	629	34	in	in	IN
cord-006860-a3b8hyyr	629	35	decreased	decrease	VBN
cord-006860-a3b8hyyr	629	36	values	value	NNS
cord-006860-a3b8hyyr	629	37	or	or	CC
cord-006860-a3b8hyyr	629	38	even	even	RB
cord-006860-a3b8hyyr	629	39	apparent	apparent	JJ
cord-006860-a3b8hyyr	629	40	deficiency	deficiency	NN
cord-006860-a3b8hyyr	629	41	(	(	-LRB-
cord-006860-a3b8hyyr	629	42	type	type	NN
cord-006860-a3b8hyyr	629	43	II	II	NNP
cord-006860-a3b8hyyr	629	44	'	'	''
cord-006860-a3b8hyyr	629	45	)	)	-RRB-
cord-006860-a3b8hyyr	629	46	of	of	IN
cord-006860-a3b8hyyr	629	47	PC	pc	NN
cord-006860-a3b8hyyr	629	48	.	.	.
cord-006860-a3b8hyyr	630	1	or	or	CC
cord-006860-a3b8hyyr	630	2	IS	be	VBZ
cord-006860-a3b8hyyr	630	3	.	.	.
cord-006860-a3b8hyyr	631	1	In	in	IN
cord-006860-a3b8hyyr	631	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	631	3	laboratory	laboratory	NN
cord-006860-a3b8hyyr	631	4	,	,	,
cord-006860-a3b8hyyr	631	5	when	when	WRB
cord-006860-a3b8hyyr	631	6	using	use	VBG
cord-006860-a3b8hyyr	631	7	functional	functional	JJ
cord-006860-a3b8hyyr	631	8	,	,	,
cord-006860-a3b8hyyr	631	9	aVIT	aVIT	NNP
cord-006860-a3b8hyyr	631	10	-	-	HYPH
cord-006860-a3b8hyyr	631	11	based	base	VBN
cord-006860-a3b8hyyr	631	12	assay	assay	NN
cord-006860-a3b8hyyr	631	13	kits	kit	NNS
cord-006860-a3b8hyyr	631	14	for	for	IN
cord-006860-a3b8hyyr	631	15	PC	pc	NN
cord-006860-a3b8hyyr	631	16	.	.	.
cord-006860-a3b8hyyr	632	1	,	,	,
cord-006860-a3b8hyyr	632	2	IS	be	VBZ
cord-006860-a3b8hyyr	632	3	,	,	,
cord-006860-a3b8hyyr	632	4	and	and	CC
cord-006860-a3b8hyyr	632	5	APC	APC	NNP
cord-006860-a3b8hyyr	632	6	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	632	7	from	from	IN
cord-006860-a3b8hyyr	632	8	Behring	Behring	NNP
cord-006860-a3b8hyyr	632	9	(	(	-LRB-
cord-006860-a3b8hyyr	632	10	Marburg	Marburg	NNP
cord-006860-a3b8hyyr	632	11	,	,	,
cord-006860-a3b8hyyr	632	12	Germany	Germany	NNP
cord-006860-a3b8hyyr	632	13	)	)	-RRB-
cord-006860-a3b8hyyr	632	14	on	on	IN
cord-006860-a3b8hyyr	632	15	an	an	DT
cord-006860-a3b8hyyr	632	16	automatic	automatic	JJ
cord-006860-a3b8hyyr	632	17	turbidimctric	turbidimctric	JJ
cord-006860-a3b8hyyr	632	18	coagulation	coagulation	NN
cord-006860-a3b8hyyr	632	19	analyzer	analyzer	NN
cord-006860-a3b8hyyr	632	20	(	(	-LRB-
cord-006860-a3b8hyyr	632	21	Fibrintiraer	Fibrintiraer	NNP
cord-006860-a3b8hyyr	632	22	A	A	NNP
cord-006860-a3b8hyyr	632	23	,	,	,
cord-006860-a3b8hyyr	632	24	Behring	Behring	NNP
cord-006860-a3b8hyyr	632	25	)	)	-RRB-
cord-006860-a3b8hyyr	632	26	,	,	,
cord-006860-a3b8hyyr	632	27	the	the	DT
cord-006860-a3b8hyyr	632	28	interference	interference	NN
cord-006860-a3b8hyyr	632	29	in	in	IN
cord-006860-a3b8hyyr	632	30	the	the	DT
cord-006860-a3b8hyyr	632	31	IS	IS	NNP
cord-006860-a3b8hyyr	632	32	assay	assay	NN
cord-006860-a3b8hyyr	632	33	has	have	VBZ
cord-006860-a3b8hyyr	632	34	been	be	VBN
cord-006860-a3b8hyyr	632	35	observed	observe	VBN
cord-006860-a3b8hyyr	632	36	in	in	IN
cord-006860-a3b8hyyr	632	37	a	a	DT
cord-006860-a3b8hyyr	632	38	very	very	RB
cord-006860-a3b8hyyr	632	39	pronounced	pronounce	VBN
cord-006860-a3b8hyyr	632	40	manner	manner	NN
cord-006860-a3b8hyyr	632	41	soon	soon	RB
cord-006860-a3b8hyyr	632	42	after	after	IN
cord-006860-a3b8hyyr	632	43	the	the	DT
cord-006860-a3b8hyyr	632	44	introduction	introduction	NN
cord-006860-a3b8hyyr	632	45	of	of	IN
cord-006860-a3b8hyyr	632	46	APC	APC	NNP
cord-006860-a3b8hyyr	632	47	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	632	48	testing	testing	NN
cord-006860-a3b8hyyr	632	49	into	into	IN
cord-006860-a3b8hyyr	632	50	the	the	DT
cord-006860-a3b8hyyr	632	51	standard	standard	JJ
cord-006860-a3b8hyyr	632	52	laboratory	laboratory	NN
cord-006860-a3b8hyyr	632	53	procedure	procedure	NN
cord-006860-a3b8hyyr	632	54	for	for	IN
cord-006860-a3b8hyyr	632	55	patients	patient	NNS
cord-006860-a3b8hyyr	632	56	with	with	IN
cord-006860-a3b8hyyr	632	57	thrumbophilia	thrumbophilia	NNP
cord-006860-a3b8hyyr	632	58	.	.	.
cord-006860-a3b8hyyr	633	1	Yet	yet	CC
cord-006860-a3b8hyyr	633	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	633	3	were	be	VBD
cord-006860-a3b8hyyr	633	4	not	not	RB
cord-006860-a3b8hyyr	633	5	aware	aware	JJ
cord-006860-a3b8hyyr	633	6	of	of	IN
cord-006860-a3b8hyyr	633	7	an	an	DT
cord-006860-a3b8hyyr	633	8	interferenca	interferenca	NNS
cord-006860-a3b8hyyr	633	9	caused	cause	VBN
cord-006860-a3b8hyyr	633	10	by	by	IN
cord-006860-a3b8hyyr	633	11	APC	APC	NNP
cord-006860-a3b8hyyr	633	12	resistance	resistance	NN
cord-006860-a3b8hyyr	633	13	in	in	IN
cord-006860-a3b8hyyr	633	14	the	the	DT
cord-006860-a3b8hyyr	633	15	PC	pc	NN
cord-006860-a3b8hyyr	633	16	test	test	NN
cord-006860-a3b8hyyr	633	17	.	.	.
cord-006860-a3b8hyyr	634	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	634	2	therefore	therefore	RB
cord-006860-a3b8hyyr	634	3	evaluated	evaluate	VBD
cord-006860-a3b8hyyr	634	4	our	-PRON-	PRP$
cord-006860-a3b8hyyr	634	5	results	result	NNS
cord-006860-a3b8hyyr	634	6	for	for	IN
cord-006860-a3b8hyyr	634	7	PC	pc	NN
cord-006860-a3b8hyyr	634	8	eed	eed	NN
cord-006860-a3b8hyyr	634	9	PS	PS	NNP
cord-006860-a3b8hyyr	634	10	with	with	IN
cord-006860-a3b8hyyr	634	11	respnet	respnet	NNS
cord-006860-a3b8hyyr	634	12	to	to	IN
cord-006860-a3b8hyyr	634	13	APC	APC	NNP
cord-006860-a3b8hyyr	634	14	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	634	15	status	status	NN
cord-006860-a3b8hyyr	634	16	in	in	IN
cord-006860-a3b8hyyr	634	17	a	a	DT
cord-006860-a3b8hyyr	634	18	retrospective	retrospective	JJ
cord-006860-a3b8hyyr	634	19	analysis	analysis	NN
cord-006860-a3b8hyyr	634	20	.	.	.
cord-006860-a3b8hyyr	635	1	Exclusion	exclusion	NN
cord-006860-a3b8hyyr	635	2	criteria	criterion	NNS
cord-006860-a3b8hyyr	635	3	were	be	VBD
cord-006860-a3b8hyyr	635	4	:	:	:
cord-006860-a3b8hyyr	635	5	oral	oral	JJ
cord-006860-a3b8hyyr	635	6	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	635	7	therapy	therapy	NN
cord-006860-a3b8hyyr	635	8	with	with	IN
cord-006860-a3b8hyyr	635	9	vitamin	vitamin	NN
cord-006860-a3b8hyyr	635	10	K	K	NNP
cord-006860-a3b8hyyr	635	11	antagonists	antagonist	NNS
cord-006860-a3b8hyyr	635	12	,	,	,
cord-006860-a3b8hyyr	635	13	impaired	impaired	JJ
cord-006860-a3b8hyyr	635	14	liver	liver	NN
cord-006860-a3b8hyyr	635	15	function	function	NN
cord-006860-a3b8hyyr	635	16	,	,	,
cord-006860-a3b8hyyr	635	17	borderline	borderline	JJ
cord-006860-a3b8hyyr	635	18	result	result	NN
cord-006860-a3b8hyyr	635	19	in	in	IN
cord-006860-a3b8hyyr	635	20	the	the	DT
cord-006860-a3b8hyyr	635	21	APC	APC	NNP
cord-006860-a3b8hyyr	635	22	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	635	23	test	test	NN
cord-006860-a3b8hyyr	635	24	,	,	,
cord-006860-a3b8hyyr	635	25	known	know	VBN
cord-006860-a3b8hyyr	635	26	analytical	analytical	JJ
cord-006860-a3b8hyyr	635	27	intedercnc	intedercnc	NNP
cord-006860-a3b8hyyr	635	28	*	*	NFP
cord-006860-a3b8hyyr	635	29	other	other	JJ
cord-006860-a3b8hyyr	635	30	than	than	IN
cord-006860-a3b8hyyr	635	31	APC	APC	NNP
cord-006860-a3b8hyyr	635	32	resistance	resistance	NN
cord-006860-a3b8hyyr	635	33	(	(	-LRB-
cord-006860-a3b8hyyr	635	34	e.g.	e.g.	IN
cord-006860-a3b8hyyr	635	35	elevated	elevated	JJ
cord-006860-a3b8hyyr	635	36	factor	factor	NN
cord-006860-a3b8hyyr	635	37	VIII	VIII	NNP
cord-006860-a3b8hyyr	635	38	:	:	:
cord-006860-a3b8hyyr	635	39	C	C	NNP
cord-006860-a3b8hyyr	635	40	)	)	-RRB-
cord-006860-a3b8hyyr	635	41	.	.	.
cord-006860-a3b8hyyr	636	1	Resu	resu	NN
cord-006860-a3b8hyyr	636	2	/	/	SYM
cord-006860-a3b8hyyr	636	3	ts	ts	NN
cord-006860-a3b8hyyr	636	4	:	:	:
cord-006860-a3b8hyyr	637	1	Apparant	apparant	JJ
cord-006860-a3b8hyyr	637	2	PC	pc	NN
cord-006860-a3b8hyyr	637	3	activity	activity	NN
cord-006860-a3b8hyyr	637	4	was	be	VBD
cord-006860-a3b8hyyr	637	5	slightly	slightly	RB
cord-006860-a3b8hyyr	637	6	(	(	-LRB-
cord-006860-a3b8hyyr	637	7	12	12	CD
cord-006860-a3b8hyyr	637	8	%	%	NN
cord-006860-a3b8hyyr	637	9	)	)	-RRB-
cord-006860-a3b8hyyr	637	10	lower	low	JJR
cord-006860-a3b8hyyr	637	11	and	and	CC
cord-006860-a3b8hyyr	637	12	apparent	apparent	JJ
cord-006860-a3b8hyyr	637	13	PS	PS	NNP
cord-006860-a3b8hyyr	637	14	activity	activity	NN
cord-006860-a3b8hyyr	637	15	was	be	VBD
cord-006860-a3b8hyyr	637	16	grossly	grossly	RB
cord-006860-a3b8hyyr	637	17	(	(	-LRB-
cord-006860-a3b8hyyr	637	18	45	45	CD
cord-006860-a3b8hyyr	637	19	%	%	NN
cord-006860-a3b8hyyr	637	20	)	)	-RRB-
cord-006860-a3b8hyyr	637	21	lower	low	JJR
cord-006860-a3b8hyyr	637	22	in	in	IN
cord-006860-a3b8hyyr	637	23	APe	ape	JJ
cord-006860-a3b8hyyr	637	24	resistent	resistent	NN
cord-006860-a3b8hyyr	637	25	patients	patient	NNS
cord-006860-a3b8hyyr	637	26	than	than	IN
cord-006860-a3b8hyyr	637	27	in	in	IN
cord-006860-a3b8hyyr	637	28	patients	patient	NNS
cord-006860-a3b8hyyr	637	29	with	with	IN
cord-006860-a3b8hyyr	637	30	normal	normal	JJ
cord-006860-a3b8hyyr	637	31	APC	APC	NNP
cord-006860-a3b8hyyr	637	32	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	637	33	:	:	:
cord-006860-a3b8hyyr	638	1	There	there	EX
cord-006860-a3b8hyyr	638	2	was	be	VBD
cord-006860-a3b8hyyr	638	3	no	no	DT
cord-006860-a3b8hyyr	638	4	case	case	NN
cord-006860-a3b8hyyr	638	5	with	with	IN
cord-006860-a3b8hyyr	638	6	a	a	DT
cord-006860-a3b8hyyr	638	7	presumed	presume	VBN
cord-006860-a3b8hyyr	638	8	du	du	NNP
cord-006860-a3b8hyyr	638	9	~	~	CD
cord-006860-a3b8hyyr	638	10	l	l	NN
cord-006860-a3b8hyyr	638	11	defect	defect	NN
cord-006860-a3b8hyyr	638	12	of	of	IN
cord-006860-a3b8hyyr	638	13	both	both	DT
cord-006860-a3b8hyyr	638	14	At~	at~	JJ
cord-006860-a3b8hyyr	638	15	rnsistaac¢	rnsistaac¢	NN
cord-006860-a3b8hyyr	638	16	and	and	CC
cord-006860-a3b8hyyr	638	17	PC	pc	NN
cord-006860-a3b8hyyr	638	18	deficiency	deficiency	NN
cord-006860-a3b8hyyr	638	19	.	.	.
cord-006860-a3b8hyyr	639	1	In	in	IN
cord-006860-a3b8hyyr	639	2	addition	addition	NN
cord-006860-a3b8hyyr	639	3	,	,	,
cord-006860-a3b8hyyr	639	4	none	none	NN
cord-006860-a3b8hyyr	639	5	of	of	IN
cord-006860-a3b8hyyr	639	6	the	the	DT
cord-006860-a3b8hyyr	639	7	few	few	JJ
cord-006860-a3b8hyyr	639	8	patients	patient	NNS
cord-006860-a3b8hyyr	639	9	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	639	10	with	with	IN
cord-006860-a3b8hyyr	639	11	PC	pc	NN
cord-006860-a3b8hyyr	639	12	deficiency	deficiency	NN
cord-006860-a3b8hyyr	639	13	before	before	IN
cord-006860-a3b8hyyr	639	14	the	the	DT
cord-006860-a3b8hyyr	639	15	introduction	introduction	NN
cord-006860-a3b8hyyr	639	16	of	of	IN
cord-006860-a3b8hyyr	639	17	the	the	DT
cord-006860-a3b8hyyr	639	18	APC	APC	NNP
cord-006860-a3b8hyyr	639	19	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	639	20	assay	assay	NN
cord-006860-a3b8hyyr	639	21	turned	turn	VBD
cord-006860-a3b8hyyr	639	22	out	out	RP
cord-006860-a3b8hyyr	639	23	to	to	IN
cord-006860-a3b8hyyr	639	24	Ix	Ix	NNP
cord-006860-a3b8hyyr	639	25	:	:	:
cord-006860-a3b8hyyr	639	26	APC	APC	NNP
cord-006860-a3b8hyyr	639	27	resistent	resistent	NNP
cord-006860-a3b8hyyr	639	28	.	.	.
cord-006860-a3b8hyyr	640	1	Much	much	RB
cord-006860-a3b8hyyr	640	2	more	more	JJR
cord-006860-a3b8hyyr	640	3	of	of	IN
cord-006860-a3b8hyyr	640	4	a	a	DT
cord-006860-a3b8hyyr	640	5	problem	problem	NN
cord-006860-a3b8hyyr	640	6	is	be	VBZ
cord-006860-a3b8hyyr	640	7	the	the	DT
cord-006860-a3b8hyyr	640	8	known	know	VBN
cord-006860-a3b8hyyr	640	9	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	640	10	of	of	IN
cord-006860-a3b8hyyr	640	11	the	the	DT
cord-006860-a3b8hyyr	640	12	PC	pc	NN
cord-006860-a3b8hyyr	640	13	test	test	NN
cord-006860-a3b8hyyr	640	14	to	to	IN
cord-006860-a3b8hyyr	640	15	an	an	DT
cord-006860-a3b8hyyr	640	16	elevated	elevated	JJ
cord-006860-a3b8hyyr	640	17	factor	factor	NN
cord-006860-a3b8hyyr	640	18	VIII	VIII	NNP
cord-006860-a3b8hyyr	640	19	concentration	concentration	NN
cord-006860-a3b8hyyr	640	20	which	which	WDT
cord-006860-a3b8hyyr	640	21	is	be	VBZ
cord-006860-a3b8hyyr	640	22	quite	quite	PDT
cord-006860-a3b8hyyr	640	23	a	a	DT
cord-006860-a3b8hyyr	640	24	common	common	JJ
cord-006860-a3b8hyyr	640	25	finding	finding	NN
cord-006860-a3b8hyyr	640	26	among	among	IN
cord-006860-a3b8hyyr	640	27	hospital	hospital	NN
cord-006860-a3b8hyyr	640	28	patients	patient	NNS
cord-006860-a3b8hyyr	640	29	but	but	CC
cord-006860-a3b8hyyr	640	30	rarely	rarely	RB
cord-006860-a3b8hyyr	640	31	known	know	VBN
cord-006860-a3b8hyyr	640	32	in	in	IN
cord-006860-a3b8hyyr	640	33	an	an	DT
cord-006860-a3b8hyyr	640	34	individual	individual	JJ
cord-006860-a3b8hyyr	640	35	case	case	NN
cord-006860-a3b8hyyr	640	36	.	.	.
cord-006860-a3b8hyyr	641	1	By	by	IN
cord-006860-a3b8hyyr	641	2	aeccelerating	aeccelerate	VBG
cord-006860-a3b8hyyr	641	3	the	the	DT
cord-006860-a3b8hyyr	641	4	clotting	clotting	NN
cord-006860-a3b8hyyr	641	5	process	process	NN
cord-006860-a3b8hyyr	641	6	,	,	,
cord-006860-a3b8hyyr	641	7	elevated	elevated	JJ
cord-006860-a3b8hyyr	641	8	factor	factor	NN
cord-006860-a3b8hyyr	641	9	VIII	VIII	NNP
cord-006860-a3b8hyyr	641	10	can	can	MD
cord-006860-a3b8hyyr	641	11	cause	cause	VB
cord-006860-a3b8hyyr	641	12	apparent	apparent	JJ
cord-006860-a3b8hyyr	641	13	PC	pc	NN
cord-006860-a3b8hyyr	641	14	deficiency	deficiency	NN
cord-006860-a3b8hyyr	641	15	that	that	WDT
cord-006860-a3b8hyyr	641	16	can	can	MD
cord-006860-a3b8hyyr	641	17	not	not	RB
cord-006860-a3b8hyyr	641	18	be	be	VB
cord-006860-a3b8hyyr	641	19	confirmed	confirm	VBN
cord-006860-a3b8hyyr	641	20	in	in	IN
cord-006860-a3b8hyyr	641	21	a	a	DT
cord-006860-a3b8hyyr	641	22	chromogunie	chromogunie	JJ
cord-006860-a3b8hyyr	641	23	PC	pc	NN
cord-006860-a3b8hyyr	641	24	assay	assay	NN
cord-006860-a3b8hyyr	641	25	.	.	.
cord-006860-a3b8hyyr	642	1	,	,	,
cord-006860-a3b8hyyr	642	2	Clearly	clearly	RB
cord-006860-a3b8hyyr	642	3	,	,	,
cord-006860-a3b8hyyr	642	4	when	when	WRB
cord-006860-a3b8hyyr	642	5	combined	combine	VBN
cord-006860-a3b8hyyr	642	6	with	with	IN
cord-006860-a3b8hyyr	642	7	APC	APC	NNP
cord-006860-a3b8hyyr	642	8	resistance	resistance	NN
cord-006860-a3b8hyyr	642	9	,	,	,
cord-006860-a3b8hyyr	642	10	this	this	DT
cord-006860-a3b8hyyr	642	11	problem	problem	NN
cord-006860-a3b8hyyr	642	12	is	be	VBZ
cord-006860-a3b8hyyr	642	13	exspacted	exspacte	VBN
cord-006860-a3b8hyyr	642	14	to	to	TO
cord-006860-a3b8hyyr	642	15	be	be	VB
cord-006860-a3b8hyyr	642	16	more	more	RBR
cord-006860-a3b8hyyr	642	17	severe	severe	JJ
cord-006860-a3b8hyyr	642	18	.	.	.
cord-006860-a3b8hyyr	643	1	On	on	IN
cord-006860-a3b8hyyr	643	2	the	the	DT
cord-006860-a3b8hyyr	643	3	other	other	JJ
cord-006860-a3b8hyyr	643	4	hand	hand	NN
cord-006860-a3b8hyyr	643	5	,	,	,
cord-006860-a3b8hyyr	643	6	the	the	DT
cord-006860-a3b8hyyr	643	7	comhination	comhination	NN
cord-006860-a3b8hyyr	643	8	of	of	IN
cord-006860-a3b8hyyr	643	9	both	both	CC
cord-006860-a3b8hyyr	643	10	APC	APC	NNP
cord-006860-a3b8hyyr	643	11	resistance	resistance	NN
cord-006860-a3b8hyyr	643	12	and	and	CC
cord-006860-a3b8hyyr	643	13	apparent	apparent	JJ
cord-006860-a3b8hyyr	643	14	IS	IS	NNP
cord-006860-a3b8hyyr	643	15	deficiency	deficiency	NN
cord-006860-a3b8hyyr	643	16	was	be	VBD
cord-006860-a3b8hyyr	643	17	found	find	VBN
cord-006860-a3b8hyyr	643	18	on	on	IN
cord-006860-a3b8hyyr	643	19	a	a	DT
cord-006860-a3b8hyyr	643	20	regular	regular	JJ
cord-006860-a3b8hyyr	643	21	basis	basis	NN
cord-006860-a3b8hyyr	643	22	with	with	IN
cord-006860-a3b8hyyr	643	23	many	many	JJ
cord-006860-a3b8hyyr	643	24	decreased	decrease	VBD
cord-006860-a3b8hyyr	643	25	and	and	CC
cord-006860-a3b8hyyr	643	26	some	some	DT
cord-006860-a3b8hyyr	643	27	bordeflinc	bordeflinc	NN
cord-006860-a3b8hyyr	643	28	values	value	NNS
cord-006860-a3b8hyyr	643	29	for	for	IN
cord-006860-a3b8hyyr	643	30	IS	is	NN
cord-006860-a3b8hyyr	644	1	but	but	CC
cord-006860-a3b8hyyr	644	2	only	only	RB
cord-006860-a3b8hyyr	644	3	few	few	JJ
cord-006860-a3b8hyyr	644	4	in	in	IN
cord-006860-a3b8hyyr	644	5	the	the	DT
cord-006860-a3b8hyyr	644	6	lower	low	JJR
cord-006860-a3b8hyyr	644	7	normal	normal	JJ
cord-006860-a3b8hyyr	644	8	range	range	NN
cord-006860-a3b8hyyr	644	9	and	and	CC
cord-006860-a3b8hyyr	644	10	virtually	virtually	RB
cord-006860-a3b8hyyr	644	11	none	none	NN
cord-006860-a3b8hyyr	644	12	in	in	IN
cord-006860-a3b8hyyr	644	13	the	the	DT
cord-006860-a3b8hyyr	644	14	upper	upper	JJ
cord-006860-a3b8hyyr	644	15	non	non	AFX
cord-006860-a3b8hyyr	644	16	~	~	NNP
cord-006860-a3b8hyyr	644	17	al	al	NNP
cord-006860-a3b8hyyr	644	18	range	range	NNP
cord-006860-a3b8hyyr	644	19	.	.	.
cord-006860-a3b8hyyr	645	1	Also	also	RB
cord-006860-a3b8hyyr	645	2	,	,	,
cord-006860-a3b8hyyr	645	3	several	several	JJ
cord-006860-a3b8hyyr	645	4	#	#	NN
cord-006860-a3b8hyyr	645	5	eats	eat	VBZ
cord-006860-a3b8hyyr	645	6	previously	previously	RB
cord-006860-a3b8hyyr	645	7	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	645	8	with	with	IN
cord-006860-a3b8hyyr	645	9	IS	IS	NNP
cord-006860-a3b8hyyr	645	10	deficiency	deficiency	NN
cord-006860-a3b8hyyr	645	11	turned	turn	VBD
cord-006860-a3b8hyyr	645	12	out	out	RP
cord-006860-a3b8hyyr	645	13	to	to	TO
cord-006860-a3b8hyyr	645	14	be	be	VB
cord-006860-a3b8hyyr	645	15	PC	pc	NN
cord-006860-a3b8hyyr	645	16	resistent	resistent	NN
cord-006860-a3b8hyyr	645	17	,	,	,
cord-006860-a3b8hyyr	645	18	and	and	CC
cord-006860-a3b8hyyr	645	19	the	the	DT
cord-006860-a3b8hyyr	645	20	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	645	21	had	have	VBD
cord-006860-a3b8hyyr	645	22	to	to	TO
cord-006860-a3b8hyyr	645	23	be	be	VB
cord-006860-a3b8hyyr	645	24	corrected	correct	VBN
cord-006860-a3b8hyyr	645	25	,	,	,
cord-006860-a3b8hyyr	645	26	but	but	CC
cord-006860-a3b8hyyr	645	27	dual	dual	JJ
cord-006860-a3b8hyyr	645	28	defects	defect	NNS
cord-006860-a3b8hyyr	645	29	can	can	MD
cord-006860-a3b8hyyr	645	30	not	not	RB
cord-006860-a3b8hyyr	645	31	be	be	VB
cord-006860-a3b8hyyr	645	32	ruled	rule	VBN
cord-006860-a3b8hyyr	645	33	out	out	RP
cord-006860-a3b8hyyr	645	34	.	.	.
cord-006860-a3b8hyyr	646	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	646	2	:	:	:
cord-006860-a3b8hyyr	647	1	For	for	IN
cord-006860-a3b8hyyr	647	2	,	,	,
cord-006860-a3b8hyyr	647	3	the	the	DT
cord-006860-a3b8hyyr	647	4	interpretation	interpretation	NN
cord-006860-a3b8hyyr	647	5	of	of	IN
cord-006860-a3b8hyyr	647	6	PC	pc	NN
cord-006860-a3b8hyyr	647	7	and/or	and/or	CC
cord-006860-a3b8hyyr	647	8	1:"3	1:"3	CD
cord-006860-a3b8hyyr	647	9	values	value	NNS
cord-006860-a3b8hyyr	647	10	from	from	IN
cord-006860-a3b8hyyr	647	11	clotting	clot	VBG
cord-006860-a3b8hyyr	647	12	assays	assay	NNS
cord-006860-a3b8hyyr	647	13	the	the	DT
cord-006860-a3b8hyyr	647	14	APC	APC	NNP
cord-006860-a3b8hyyr	647	15	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	647	16	status	status	NN
cord-006860-a3b8hyyr	647	17	must	must	MD
cord-006860-a3b8hyyr	647	18	be	be	VB
cord-006860-a3b8hyyr	647	19	considered	consider	VBN
cord-006860-a3b8hyyr	647	20	.	.	.
cord-006860-a3b8hyyr	648	1	When	when	WRB
cord-006860-a3b8hyyr	648	2	APC	APC	NNP
cord-006860-a3b8hyyr	648	3	resistance	resistance	NN
cord-006860-a3b8hyyr	648	4	and	and	CC
cord-006860-a3b8hyyr	648	5	an	an	DT
cord-006860-a3b8hyyr	648	6	apparent	apparent	JJ
cord-006860-a3b8hyyr	648	7	deficiency	deficiency	NN
cord-006860-a3b8hyyr	648	8	of	of	IN
cord-006860-a3b8hyyr	648	9	PC	pc	NN
cord-006860-a3b8hyyr	648	10	or	or	CC
cord-006860-a3b8hyyr	648	11	IS	be	VBZ
cord-006860-a3b8hyyr	648	12	is	be	VBZ
cord-006860-a3b8hyyr	648	13	found	find	VBN
cord-006860-a3b8hyyr	648	14	,	,	,
cord-006860-a3b8hyyr	648	15	a	a	DT
cord-006860-a3b8hyyr	648	16	type	type	NN
cord-006860-a3b8hyyr	648	17	I	-PRON-	PRP
cord-006860-a3b8hyyr	648	18	deficiency	deficiency	NN
cord-006860-a3b8hyyr	648	19	may	may	MD
cord-006860-a3b8hyyr	648	20	be	be	VB
cord-006860-a3b8hyyr	648	21	confirmed	confirm	VBN
cord-006860-a3b8hyyr	648	22	or	or	CC
cord-006860-a3b8hyyr	648	23	ruled	rule	VBN
cord-006860-a3b8hyyr	648	24	out	out	RP
cord-006860-a3b8hyyr	648	25	using	use	VBG
cord-006860-a3b8hyyr	648	26	antigen	antigen	NN
cord-006860-a3b8hyyr	648	27	assays	assay	NNS
cord-006860-a3b8hyyr	648	28	,	,	,
cord-006860-a3b8hyyr	648	29	but	but	CC
cord-006860-a3b8hyyr	648	30	at	at	IN
cord-006860-a3b8hyyr	648	31	present	present	JJ
cord-006860-a3b8hyyr	648	32	,	,	,
cord-006860-a3b8hyyr	648	33	there	there	EX
cord-006860-a3b8hyyr	648	34	seems	seem	VBZ
cord-006860-a3b8hyyr	648	35	to	to	TO
cord-006860-a3b8hyyr	648	36	be	be	VB
cord-006860-a3b8hyyr	648	37	no	no	DT
cord-006860-a3b8hyyr	648	38	reliable	reliable	JJ
cord-006860-a3b8hyyr	648	39	way	way	NN
cord-006860-a3b8hyyr	648	40	other	other	JJ
cord-006860-a3b8hyyr	648	41	than	than	IN
cord-006860-a3b8hyyr	648	42	genetic	genetic	JJ
cord-006860-a3b8hyyr	648	43	analysis	analysis	NN
cord-006860-a3b8hyyr	648	44	to	to	TO
cord-006860-a3b8hyyr	648	45	address	address	VB
cord-006860-a3b8hyyr	648	46	the	the	DT
cord-006860-a3b8hyyr	648	47	question	question	NN
cord-006860-a3b8hyyr	648	48	of	of	IN
cord-006860-a3b8hyyr	648	49	dual	dual	JJ
cord-006860-a3b8hyyr	648	50	defects	defect	NNS
cord-006860-a3b8hyyr	648	51	with	with	IN
cord-006860-a3b8hyyr	648	52	presumed	presumed	JJ
cord-006860-a3b8hyyr	648	53	type	type	NN
cord-006860-a3b8hyyr	648	54	II	II	NNP
cord-006860-a3b8hyyr	648	55	deficiency	deficiency	NN
cord-006860-a3b8hyyr	648	56	,	,	,
cord-006860-a3b8hyyr	648	57	especially	especially	RB
cord-006860-a3b8hyyr	648	58	in	in	IN
cord-006860-a3b8hyyr	648	59	the	the	DT
cord-006860-a3b8hyyr	648	60	case	case	NN
cord-006860-a3b8hyyr	648	61	of	of	IN
cord-006860-a3b8hyyr	648	62	PS	PS	NNP
cord-006860-a3b8hyyr	648	63	.	.	.
cord-006860-a3b8hyyr	649	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	649	2	,	,	,
cord-006860-a3b8hyyr	649	3	there	there	EX
cord-006860-a3b8hyyr	649	4	is	be	VBZ
cord-006860-a3b8hyyr	649	5	a	a	DT
cord-006860-a3b8hyyr	649	6	clear	clear	JJ
cord-006860-a3b8hyyr	649	7	need	need	NN
cord-006860-a3b8hyyr	649	8	for	for	IN
cord-006860-a3b8hyyr	649	9	analytical	analytical	JJ
cord-006860-a3b8hyyr	649	10	improvementS	improvementS	NNP
cord-006860-a3b8hyyr	649	11	and	and	CC
cord-006860-a3b8hyyr	649	12	the	the	DT
cord-006860-a3b8hyyr	649	13	development	development	NN
cord-006860-a3b8hyyr	649	14	of	of	IN
cord-006860-a3b8hyyr	649	15	functional	functional	JJ
cord-006860-a3b8hyyr	649	16	assays	assay	NNS
cord-006860-a3b8hyyr	649	17	that	that	WDT
cord-006860-a3b8hyyr	649	18	are	be	VBP
cord-006860-a3b8hyyr	649	19	less	less	RBR
cord-006860-a3b8hyyr	649	20	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	649	21	to	to	IN
cord-006860-a3b8hyyr	649	22	interference	interference	NN
cord-006860-a3b8hyyr	649	23	by	by	IN
cord-006860-a3b8hyyr	649	24	APC	APC	NNP
cord-006860-a3b8hyyr	649	25	resistance	resistance	NN
cord-006860-a3b8hyyr	649	26	.	.	.
cord-006860-a3b8hyyr	650	1	The	the	DT
cord-006860-a3b8hyyr	650	2	most	most	RBS
cord-006860-a3b8hyyr	650	3	common	common	JJ
cord-006860-a3b8hyyr	650	4	inherited	inherit	VBN
cord-006860-a3b8hyyr	650	5	risk	risk	NN
cord-006860-a3b8hyyr	650	6	factor	factor	NN
cord-006860-a3b8hyyr	650	7	for	for	IN
cord-006860-a3b8hyyr	650	8	venous	venous	JJ
cord-006860-a3b8hyyr	650	9	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	650	10	is	be	VBZ
cord-006860-a3b8hyyr	650	11	the	the	DT
cord-006860-a3b8hyyr	650	12	resistance	resistance	NN
cord-006860-a3b8hyyr	650	13	to	to	IN
cord-006860-a3b8hyyr	650	14	activated	activate	VBN
cord-006860-a3b8hyyr	650	15	protein	protein	NN
cord-006860-a3b8hyyr	650	16	C	C	NNP
cord-006860-a3b8hyyr	650	17	(	(	-LRB-
cord-006860-a3b8hyyr	650	18	APC	APC	NNP
cord-006860-a3b8hyyr	650	19	)	)	-RRB-
cord-006860-a3b8hyyr	650	20	.	.	.
cord-006860-a3b8hyyr	651	1	The	the	DT
cord-006860-a3b8hyyr	651	2	main	main	JJ
cord-006860-a3b8hyyr	651	3	reason	reason	NN
cord-006860-a3b8hyyr	651	4	for	for	IN
cord-006860-a3b8hyyr	651	5	this	this	DT
cord-006860-a3b8hyyr	651	6	resistance	resistance	NN
cord-006860-a3b8hyyr	651	7	is	be	VBZ
cord-006860-a3b8hyyr	651	8	a	a	DT
cord-006860-a3b8hyyr	651	9	point	point	NN
cord-006860-a3b8hyyr	651	10	mutation	mutation	NN
cord-006860-a3b8hyyr	651	11	in	in	IN
cord-006860-a3b8hyyr	651	12	the	the	DT
cord-006860-a3b8hyyr	651	13	gene	gene	NN
cord-006860-a3b8hyyr	651	14	of	of	IN
cord-006860-a3b8hyyr	651	15	dotting	dot	VBG
cord-006860-a3b8hyyr	651	16	factor	factor	NN
cord-006860-a3b8hyyr	651	17	V	v	NN
cord-006860-a3b8hyyr	651	18	(	(	-LRB-
cord-006860-a3b8hyyr	651	19	F	F	NNP
cord-006860-a3b8hyyr	651	20	V	V	NNP
cord-006860-a3b8hyyr	651	21	)	)	-RRB-
cord-006860-a3b8hyyr	651	22	.	.	.
cord-006860-a3b8hyyr	652	1	A	a	DT
cord-006860-a3b8hyyr	652	2	nueleotide	nueleotide	NN
cord-006860-a3b8hyyr	652	3	exchange	exchange	NN
cord-006860-a3b8hyyr	652	4	leads	lead	VBZ
cord-006860-a3b8hyyr	652	5	to	to	IN
cord-006860-a3b8hyyr	652	6	a	a	DT
cord-006860-a3b8hyyr	652	7	different	different	JJ
cord-006860-a3b8hyyr	652	8	amino	amino	NN
cord-006860-a3b8hyyr	652	9	acid	acid	NN
cord-006860-a3b8hyyr	652	10	sequence	sequence	NN
cord-006860-a3b8hyyr	652	11	in	in	IN
cord-006860-a3b8hyyr	652	12	the	the	DT
cord-006860-a3b8hyyr	652	13	protein	protein	NN
cord-006860-a3b8hyyr	652	14	and	and	CC
cord-006860-a3b8hyyr	652	15	thus	thus	RB
cord-006860-a3b8hyyr	652	16	to	to	IN
cord-006860-a3b8hyyr	652	17	the	the	DT
cord-006860-a3b8hyyr	652	18	loss	loss	NN
cord-006860-a3b8hyyr	652	19	of	of	IN
cord-006860-a3b8hyyr	652	20	one	one	CD
cord-006860-a3b8hyyr	652	21	of	of	IN
cord-006860-a3b8hyyr	652	22	the	the	DT
cord-006860-a3b8hyyr	652	23	cleavage	cleavage	NN
cord-006860-a3b8hyyr	652	24	sides	side	NNS
cord-006860-a3b8hyyr	652	25	which	which	WDT
cord-006860-a3b8hyyr	652	26	is	be	VBZ
cord-006860-a3b8hyyr	652	27	important	important	JJ
cord-006860-a3b8hyyr	652	28	for	for	IN
cord-006860-a3b8hyyr	652	29	the	the	DT
cord-006860-a3b8hyyr	652	30	inactivation	inactivation	NN
cord-006860-a3b8hyyr	652	31	of	of	IN
cord-006860-a3b8hyyr	652	32	the	the	DT
cord-006860-a3b8hyyr	652	33	procoagulatory	procoagulatory	NN
cord-006860-a3b8hyyr	652	34	form	form	NN
cord-006860-a3b8hyyr	652	35	off	off	RP
cord-006860-a3b8hyyr	652	36	V.	V.	NNP
cord-006860-a3b8hyyr	653	1	The	the	DT
cord-006860-a3b8hyyr	653	2	imbalance	imbalance	NN
cord-006860-a3b8hyyr	653	3	in	in	IN
cord-006860-a3b8hyyr	653	4	the	the	DT
cord-006860-a3b8hyyr	653	5	coagalation	coagalation	NN
cord-006860-a3b8hyyr	653	6	cascade	cascade	NN
cord-006860-a3b8hyyr	653	7	leads	lead	VBZ
cord-006860-a3b8hyyr	653	8	to	to	IN
cord-006860-a3b8hyyr	653	9	a	a	DT
cord-006860-a3b8hyyr	653	10	strong	strong	JJ
cord-006860-a3b8hyyr	653	11	risk	risk	NN
cord-006860-a3b8hyyr	653	12	for	for	IN
cord-006860-a3b8hyyr	653	13	venous	venous	JJ
cord-006860-a3b8hyyr	653	14	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	653	15	,	,	,
cord-006860-a3b8hyyr	653	16	which	which	WDT
cord-006860-a3b8hyyr	653	17	is	be	VBZ
cord-006860-a3b8hyyr	653	18	thought	think	VBN
cord-006860-a3b8hyyr	653	19	to	to	TO
cord-006860-a3b8hyyr	653	20	be	be	VB
cord-006860-a3b8hyyr	653	21	inoreaced	inoreace	VBN
cord-006860-a3b8hyyr	653	22	by	by	IN
cord-006860-a3b8hyyr	653	23	factor	factor	NN
cord-006860-a3b8hyyr	653	24	7	7	CD
cord-006860-a3b8hyyr	653	25	to	to	IN
cord-006860-a3b8hyyr	653	26	10	10	CD
cord-006860-a3b8hyyr	653	27	for	for	IN
cord-006860-a3b8hyyr	653	28	heterocygotes	heterocygotes	NNP
cord-006860-a3b8hyyr	653	29	and	and	CC
cord-006860-a3b8hyyr	653	30	about	about	RB
cord-006860-a3b8hyyr	653	31	80	80	CD
cord-006860-a3b8hyyr	653	32	for	for	IN
cord-006860-a3b8hyyr	653	33	homocygote	homocygote	NN
cord-006860-a3b8hyyr	653	34	individuals	individual	NNS
cord-006860-a3b8hyyr	653	35	.	.	.
cord-006860-a3b8hyyr	654	1	The	the	DT
cord-006860-a3b8hyyr	654	2	prevalence	prevalence	NN
cord-006860-a3b8hyyr	654	3	in	in	IN
cord-006860-a3b8hyyr	654	4	patients	patient	NNS
cord-006860-a3b8hyyr	654	5	with	with	IN
cord-006860-a3b8hyyr	654	6	a	a	DT
cord-006860-a3b8hyyr	654	7	history	history	NN
cord-006860-a3b8hyyr	654	8	of	of	IN
cord-006860-a3b8hyyr	654	9	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	654	10	is	be	VBZ
cord-006860-a3b8hyyr	654	11	about	about	RB
cord-006860-a3b8hyyr	654	12	20	20	CD
cord-006860-a3b8hyyr	654	13	%	%	NN
cord-006860-a3b8hyyr	654	14	,	,	,
cord-006860-a3b8hyyr	654	15	among	among	IN
cord-006860-a3b8hyyr	654	16	APCresistant	apcresistant	NN
cord-006860-a3b8hyyr	654	17	patients	patient	NNS
cord-006860-a3b8hyyr	654	18	as	as	RB
cord-006860-a3b8hyyr	654	19	high	high	JJ
cord-006860-a3b8hyyr	654	20	as	as	IN
cord-006860-a3b8hyyr	654	21	80	80	CD
cord-006860-a3b8hyyr	654	22	%	%	NN
cord-006860-a3b8hyyr	654	23	.	.	.
cord-006860-a3b8hyyr	655	1	Prevalence	prevalence	NN
cord-006860-a3b8hyyr	655	2	-	-	HYPH
cord-006860-a3b8hyyr	655	3	ofF	off	NN
cord-006860-a3b8hyyr	655	4	V	v	NN
cord-006860-a3b8hyyr	655	5	,	,	,
cord-006860-a3b8hyyr	655	6	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	655	7	"	"	''
cord-006860-a3b8hyyr	655	8	is	be	VBZ
cord-006860-a3b8hyyr	655	9	reported	report	VBN
cord-006860-a3b8hyyr	655	10	to	to	TO
cord-006860-a3b8hyyr	655	11	be	be	VB
cord-006860-a3b8hyyr	655	12	2	2	CD
cord-006860-a3b8hyyr	655	13	%	%	NN
cord-006860-a3b8hyyr	655	14	of	of	IN
cord-006860-a3b8hyyr	655	15	the	the	DT
cord-006860-a3b8hyyr	655	16	normal	normal	JJ
cord-006860-a3b8hyyr	655	17	population	population	NN
cord-006860-a3b8hyyr	655	18	in	in	IN
cord-006860-a3b8hyyr	655	19	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	655	20	/	/	SYM
cord-006860-a3b8hyyr	655	21	Netherlands	Netherlands	NNP
cord-006860-a3b8hyyr	655	22	and	and	CC
cord-006860-a3b8hyyr	655	23	as	as	RB
cord-006860-a3b8hyyr	655	24	high	high	JJ
cord-006860-a3b8hyyr	655	25	as	as	IN
cord-006860-a3b8hyyr	655	26	15	15	CD
cord-006860-a3b8hyyr	655	27	%	%	NN
cord-006860-a3b8hyyr	655	28	in	in	IN
cord-006860-a3b8hyyr	655	29	a	a	DT
cord-006860-a3b8hyyr	655	30	certain	certain	JJ
cord-006860-a3b8hyyr	655	31	city	city	NN
cord-006860-a3b8hyyr	655	32	in	in	IN
cord-006860-a3b8hyyr	655	33	the	the	DT
cord-006860-a3b8hyyr	655	34	south	south	NN
cord-006860-a3b8hyyr	655	35	of	of	IN
cord-006860-a3b8hyyr	655	36	Sweden	Sweden	NNP
cord-006860-a3b8hyyr	655	37	.	.	.
cord-006860-a3b8hyyr	656	1	Due	due	IN
cord-006860-a3b8hyyr	656	2	to	to	IN
cord-006860-a3b8hyyr	656	3	the	the	DT
cord-006860-a3b8hyyr	656	4	obviously	obviously	RB
cord-006860-a3b8hyyr	656	5	different	different	JJ
cord-006860-a3b8hyyr	656	6	geographic	geographic	JJ
cord-006860-a3b8hyyr	656	7	distribution	distribution	NN
cord-006860-a3b8hyyr	656	8	and	and	CC
cord-006860-a3b8hyyr	656	9	the	the	DT
cord-006860-a3b8hyyr	656	10	highly	highly	RB
cord-006860-a3b8hyyr	656	11	increased	increase	VBN
cord-006860-a3b8hyyr	656	12	risk	risk	NN
cord-006860-a3b8hyyr	656	13	of	of	IN
cord-006860-a3b8hyyr	656	14	venous	venous	JJ
cord-006860-a3b8hyyr	656	15	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	656	16	in	in	IN
cord-006860-a3b8hyyr	656	17	carriers	carrier	NNS
cord-006860-a3b8hyyr	656	18	of	of	IN
cord-006860-a3b8hyyr	656	19	the	the	DT
cord-006860-a3b8hyyr	656	20	mutation	mutation	NN
cord-006860-a3b8hyyr	656	21	investigated	investigate	VBD
cord-006860-a3b8hyyr	656	22	the	the	DT
cord-006860-a3b8hyyr	656	23	distribution	distribution	NN
cord-006860-a3b8hyyr	656	24	of	of	IN
cord-006860-a3b8hyyr	656	25	this	this	DT
cord-006860-a3b8hyyr	656	26	mutation	mutation	NN
cord-006860-a3b8hyyr	656	27	in	in	IN
cord-006860-a3b8hyyr	656	28	the	the	DT
cord-006860-a3b8hyyr	656	29	normal	normal	JJ
cord-006860-a3b8hyyr	656	30	population	population	NN
cord-006860-a3b8hyyr	656	31	of	of	IN
cord-006860-a3b8hyyr	656	32	different	different	JJ
cord-006860-a3b8hyyr	656	33	regions	region	NNS
cord-006860-a3b8hyyr	656	34	in	in	IN
cord-006860-a3b8hyyr	656	35	Germany	Germany	NNP
cord-006860-a3b8hyyr	656	36	.	.	.
cord-006860-a3b8hyyr	657	1	First	first	JJ
cord-006860-a3b8hyyr	657	2	attempts	attempt	NNS
cord-006860-a3b8hyyr	657	3	to	to	TO
cord-006860-a3b8hyyr	657	4	assess	assess	VB
cord-006860-a3b8hyyr	657	5	the	the	DT
cord-006860-a3b8hyyr	657	6	prevalence	prevalence	NN
cord-006860-a3b8hyyr	657	7	ofF	off	NN
cord-006860-a3b8hyyr	657	8	V	v	NN
cord-006860-a3b8hyyr	657	9	mutation	mutation	NN
cord-006860-a3b8hyyr	657	10	by	by	IN
cord-006860-a3b8hyyr	657	11	molecular	molecular	JJ
cord-006860-a3b8hyyr	657	12	methods	method	NNS
cord-006860-a3b8hyyr	657	13	(	(	-LRB-
cord-006860-a3b8hyyr	657	14	polymerase	polymerase	NN
cord-006860-a3b8hyyr	657	15	chain	chain	NN
cord-006860-a3b8hyyr	657	16	reaction	reaction	NN
cord-006860-a3b8hyyr	657	17	followed	follow	VBN
cord-006860-a3b8hyyr	657	18	by	by	IN
cord-006860-a3b8hyyr	657	19	restriction	restriction	NN
cord-006860-a3b8hyyr	657	20	fi'agment	fi'agment	NNP
cord-006860-a3b8hyyr	657	21	length	length	NN
cord-006860-a3b8hyyr	657	22	polymorphism	polymorphism	NN
cord-006860-a3b8hyyr	657	23	analysis	analysis	NN
cord-006860-a3b8hyyr	657	24	)	)	-RRB-
cord-006860-a3b8hyyr	657	25	revealed	reveal	VBD
cord-006860-a3b8hyyr	657	26	that	that	IN
cord-006860-a3b8hyyr	657	27	in	in	IN
cord-006860-a3b8hyyr	657	28	the	the	DT
cord-006860-a3b8hyyr	657	29	area	area	NN
cord-006860-a3b8hyyr	657	30	of	of	IN
cord-006860-a3b8hyyr	657	31	Wiirzburg	Wiirzburg	NNP
cord-006860-a3b8hyyr	657	32	7.7	7.7	CD
cord-006860-a3b8hyyr	657	33	%	%	NN
cord-006860-a3b8hyyr	657	34	of	of	IN
cord-006860-a3b8hyyr	657	35	blood	blood	NN
cord-006860-a3b8hyyr	657	36	donors	donor	NNS
cord-006860-a3b8hyyr	657	37	carry	carry	VBP
cord-006860-a3b8hyyr	657	38	the	the	DT
cord-006860-a3b8hyyr	657	39	mutation	mutation	NN
cord-006860-a3b8hyyr	657	40	,	,	,
cord-006860-a3b8hyyr	657	41	which	which	WDT
cord-006860-a3b8hyyr	657	42	is	be	VBZ
cord-006860-a3b8hyyr	657	43	significantly	significantly	RB
cord-006860-a3b8hyyr	657	44	different	different	JJ
cord-006860-a3b8hyyr	657	45	(	(	-LRB-
cord-006860-a3b8hyyr	657	46	Fischer	Fischer	NNP
cord-006860-a3b8hyyr	657	47	T	T	NNP
cord-006860-a3b8hyyr	657	48	-	-	HYPH
cord-006860-a3b8hyyr	657	49	Test	test	NN
cord-006860-a3b8hyyr	657	50	,	,	,
cord-006860-a3b8hyyr	657	51	level	level	NN
cord-006860-a3b8hyyr	657	52	of	of	IN
cord-006860-a3b8hyyr	657	53	significance	significance	NN
cord-006860-a3b8hyyr	657	54	0.05	0.05	CD
cord-006860-a3b8hyyr	657	55	%	%	NN
cord-006860-a3b8hyyr	657	56	)	)	-RRB-
cord-006860-a3b8hyyr	657	57	from	from	IN
cord-006860-a3b8hyyr	657	58	published	publish	VBN
cord-006860-a3b8hyyr	657	59	data	datum	NNS
cord-006860-a3b8hyyr	657	60	observed	observe	VBN
cord-006860-a3b8hyyr	657	61	in	in	IN
cord-006860-a3b8hyyr	657	62	Freiburg	Freiburg	NNP
cord-006860-a3b8hyyr	657	63	(	(	-LRB-
cord-006860-a3b8hyyr	657	64	3.4	3.4	CD
cord-006860-a3b8hyyr	657	65	%	%	NN
cord-006860-a3b8hyyr	657	66	)	)	-RRB-
cord-006860-a3b8hyyr	657	67	.	.	.
cord-006860-a3b8hyyr	658	1	Homburg	Homburg	NNP
cord-006860-a3b8hyyr	658	2	/	/	SYM
cord-006860-a3b8hyyr	658	3	Saar	Saar	NNP
cord-006860-a3b8hyyr	658	4	and	and	CC
cord-006860-a3b8hyyr	658	5	Harmover	Harmover	NNP
cord-006860-a3b8hyyr	658	6	revealed	reveal	VBD
cord-006860-a3b8hyyr	658	7	5.8	5.8	CD
cord-006860-a3b8hyyr	658	8	%	%	NN
cord-006860-a3b8hyyr	658	9	and	and	CC
cord-006860-a3b8hyyr	658	10	8.5	8.5	CD
cord-006860-a3b8hyyr	658	11	%	%	NN
cord-006860-a3b8hyyr	658	12	,	,	,
cord-006860-a3b8hyyr	658	13	respectively	respectively	RB
cord-006860-a3b8hyyr	658	14	,	,	,
cord-006860-a3b8hyyr	658	15	and	and	CC
cord-006860-a3b8hyyr	658	16	were	be	VBD
cord-006860-a3b8hyyr	658	17	not	not	RB
cord-006860-a3b8hyyr	658	18	significantly	significantly	RB
cord-006860-a3b8hyyr	658	19	different	different	JJ
cord-006860-a3b8hyyr	658	20	from	from	IN
cord-006860-a3b8hyyr	658	21	Wfwzborg	Wfwzborg	NNP
cord-006860-a3b8hyyr	658	22	.	.	.
cord-006860-a3b8hyyr	659	1	Further	further	JJ
cord-006860-a3b8hyyr	659	2	investigations	investigation	NNS
cord-006860-a3b8hyyr	659	3	of	of	IN
cord-006860-a3b8hyyr	659	4	blood	blood	NN
cord-006860-a3b8hyyr	659	5	somples	somple	NNS
cord-006860-a3b8hyyr	659	6	fi	fi	NN
cord-006860-a3b8hyyr	659	7	:	:	:
cord-006860-a3b8hyyr	659	8	om	om	IN
cord-006860-a3b8hyyr	659	9	other	other	JJ
cord-006860-a3b8hyyr	659	10	regions	region	NNS
cord-006860-a3b8hyyr	659	11	should	should	MD
cord-006860-a3b8hyyr	659	12	give	give	VB
cord-006860-a3b8hyyr	659	13	an	an	DT
cord-006860-a3b8hyyr	659	14	overview	overview	NN
cord-006860-a3b8hyyr	659	15	of	of	IN
cord-006860-a3b8hyyr	659	16	the	the	DT
cord-006860-a3b8hyyr	659	17	geographic	geographic	JJ
cord-006860-a3b8hyyr	659	18	distribution	distribution	NN
cord-006860-a3b8hyyr	659	19	of	of	IN
cord-006860-a3b8hyyr	659	20	this	this	DT
cord-006860-a3b8hyyr	659	21	mutation	mutation	NN
cord-006860-a3b8hyyr	659	22	in	in	IN
cord-006860-a3b8hyyr	659	23	Germany	Germany	NNP
cord-006860-a3b8hyyr	659	24	and	and	CC
cord-006860-a3b8hyyr	659	25	might	may	MD
cord-006860-a3b8hyyr	659	26	finally	finally	RB
cord-006860-a3b8hyyr	659	27	help	help	VB
cord-006860-a3b8hyyr	659	28	to	to	TO
cord-006860-a3b8hyyr	659	29	draw	draw	VB
cord-006860-a3b8hyyr	659	30	a	a	DT
cord-006860-a3b8hyyr	659	31	map	map	NN
cord-006860-a3b8hyyr	659	32	era	era	NN
cord-006860-a3b8hyyr	659	33	regional	regional	JJ
cord-006860-a3b8hyyr	659	34	risk	risk	NN
cord-006860-a3b8hyyr	659	35	of	of	IN
cord-006860-a3b8hyyr	659	36	venous	venous	JJ
cord-006860-a3b8hyyr	659	37	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	659	38	.	.	.
cord-006860-a3b8hyyr	660	1	The	the	DT
cord-006860-a3b8hyyr	660	2	regular	regular	JJ
cord-006860-a3b8hyyr	660	3	APC	APC	NNP
cord-006860-a3b8hyyr	660	4	resistance	resistance	NN
cord-006860-a3b8hyyr	660	5	test	test	NN
cord-006860-a3b8hyyr	660	6	is	be	VBZ
cord-006860-a3b8hyyr	660	7	not	not	RB
cord-006860-a3b8hyyr	660	8	applicable	applicable	JJ
cord-006860-a3b8hyyr	660	9	to	to	IN
cord-006860-a3b8hyyr	660	10	plasma	plasma	NN
cord-006860-a3b8hyyr	660	11	from	from	IN
cord-006860-a3b8hyyr	660	12	Orally	orally	RB
cord-006860-a3b8hyyr	660	13	anticoagulated	anticoagulate	VBN
cord-006860-a3b8hyyr	660	14	(	(	-LRB-
cord-006860-a3b8hyyr	660	15	OAC	OAC	NNP
cord-006860-a3b8hyyr	660	16	)	)	-RRB-
cord-006860-a3b8hyyr	660	17	or	or	CC
cord-006860-a3b8hyyr	660	18	heparinized	heparinize	VBN
cord-006860-a3b8hyyr	660	19	patients	patient	NNS
cord-006860-a3b8hyyr	660	20	due	due	JJ
cord-006860-a3b8hyyr	660	21	to	to	IN
cord-006860-a3b8hyyr	660	22	decreased	decrease	VBN
cord-006860-a3b8hyyr	660	23	levels	level	NNS
cord-006860-a3b8hyyr	660	24	of	of	IN
cord-006860-a3b8hyyr	660	25	vitamin	vitamin	NN
cord-006860-a3b8hyyr	660	26	K	k	NN
cord-006860-a3b8hyyr	660	27	-	-	HYPH
cord-006860-a3b8hyyr	660	28	dependent	dependent	JJ
cord-006860-a3b8hyyr	660	29	clotting	clotting	NN
cord-006860-a3b8hyyr	660	30	factors	factor	NNS
cord-006860-a3b8hyyr	660	31	and	and	CC
cord-006860-a3b8hyyr	660	32	to	to	IN
cord-006860-a3b8hyyr	660	33	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	660	34	inhibition	inhibition	NN
cord-006860-a3b8hyyr	660	35	by	by	IN
cord-006860-a3b8hyyr	660	36	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	660	37	,	,	,
cord-006860-a3b8hyyr	660	38	respectively	respectively	RB
cord-006860-a3b8hyyr	660	39	.	.	.
cord-006860-a3b8hyyr	661	1	The	the	DT
cord-006860-a3b8hyyr	661	2	former	former	JJ
cord-006860-a3b8hyyr	661	3	limitation	limitation	NN
cord-006860-a3b8hyyr	661	4	is	be	VBZ
cord-006860-a3b8hyyr	661	5	overcome	overcome	VBN
cord-006860-a3b8hyyr	661	6	by	by	IN
cord-006860-a3b8hyyr	661	7	prediluting	predilute	VBG
cord-006860-a3b8hyyr	661	8	samples	sample	NNS
cord-006860-a3b8hyyr	661	9	1	1	CD
cord-006860-a3b8hyyr	661	10	-	-	HYPH
cord-006860-a3b8hyyr	661	11	1	1	CD
cord-006860-a3b8hyyr	661	12	-	-	SYM
cord-006860-a3b8hyyr	661	13	4	4	CD
cord-006860-a3b8hyyr	661	14	with	with	IN
cord-006860-a3b8hyyr	661	15	FV	fv	NN
cord-006860-a3b8hyyr	661	16	-	-	HYPH
cord-006860-a3b8hyyr	661	17	defident	defident	NN
cord-006860-a3b8hyyr	661	18	plasma	plasma	NN
cord-006860-a3b8hyyr	661	19	.	.	.
cord-006860-a3b8hyyr	662	1	For	for	IN
cord-006860-a3b8hyyr	662	2	this	this	DT
cord-006860-a3b8hyyr	662	3	purpose	purpose	NN
cord-006860-a3b8hyyr	662	4	a	a	DT
cord-006860-a3b8hyyr	662	5	special	special	JJ
cord-006860-a3b8hyyr	662	6	quality	quality	NN
cord-006860-a3b8hyyr	662	7	of	of	IN
cord-006860-a3b8hyyr	662	8	FV	fv	NN
cord-006860-a3b8hyyr	662	9	-	-	HYPH
cord-006860-a3b8hyyr	662	10	deficient	deficient	JJ
cord-006860-a3b8hyyr	662	11	plasma	plasma	NN
cord-006860-a3b8hyyr	662	12	has	have	VBZ
cord-006860-a3b8hyyr	662	13	been	be	VBN
cord-006860-a3b8hyyr	662	14	prepared	prepare	VBN
cord-006860-a3b8hyyr	662	15	,	,	,
cord-006860-a3b8hyyr	662	16	which	which	WDT
cord-006860-a3b8hyyr	662	17	also	also	RB
cord-006860-a3b8hyyr	662	18	allows	allow	VBZ
cord-006860-a3b8hyyr	662	19	analysis	analysis	NN
cord-006860-a3b8hyyr	662	20	of	of	IN
cord-006860-a3b8hyyr	662	21	heparinized	heparinize	VBN
cord-006860-a3b8hyyr	662	22	plasmas	plasma	NNS
cord-006860-a3b8hyyr	662	23	.	.	.
cord-006860-a3b8hyyr	663	1	This	this	DT
cord-006860-a3b8hyyr	663	2	FV	fv	NN
cord-006860-a3b8hyyr	663	3	-	-	HYPH
cord-006860-a3b8hyyr	663	4	deficient	deficient	JJ
cord-006860-a3b8hyyr	663	5	plasma	plasma	NN
cord-006860-a3b8hyyr	663	6	has	have	VBZ
cord-006860-a3b8hyyr	663	7	now	now	RB
cord-006860-a3b8hyyr	663	8	been	be	VBN
cord-006860-a3b8hyyr	663	9	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	663	10	with	with	IN
cord-006860-a3b8hyyr	663	11	the	the	DT
cord-006860-a3b8hyyr	663	12	COATEST	COATEST	NNP
cord-006860-a3b8hyyr	663	13	APC	APC	NNP
cord-006860-a3b8hyyr	663	14	Resistance	Resistance	NNP
cord-006860-a3b8hyyr	663	15	assay	assay	NN
cord-006860-a3b8hyyr	663	16	.	.	.
cord-006860-a3b8hyyr	664	1	A	a	DT
cord-006860-a3b8hyyr	664	2	complete	complete	JJ
cord-006860-a3b8hyyr	664	3	APe	ape	NN
cord-006860-a3b8hyyr	664	4	ratio	ratio	NN
cord-006860-a3b8hyyr	664	5	discrimination	discrimination	NN
cord-006860-a3b8hyyr	664	6	for	for	IN
cord-006860-a3b8hyyr	664	7	the	the	DT
cord-006860-a3b8hyyr	664	8	FV	FV	NNP
cord-006860-a3b8hyyr	664	9	Q506	Q506	NNP
cord-006860-a3b8hyyr	664	10	mutation	mutation	NN
cord-006860-a3b8hyyr	664	11	is	be	VBZ
cord-006860-a3b8hyyr	664	12	obtained	obtain	VBN
cord-006860-a3b8hyyr	664	13	for	for	IN
cord-006860-a3b8hyyr	664	14	plasmas	plasma	NNS
cord-006860-a3b8hyyr	664	15	from	from	IN
cord-006860-a3b8hyyr	664	16	OAC	OAC	NNP
cord-006860-a3b8hyyr	664	17	and	and	CC
cord-006860-a3b8hyyr	664	18	heparin	heparin	NN
cord-006860-a3b8hyyr	664	19	patients	patient	NNS
cord-006860-a3b8hyyr	664	20	as	as	RB
cord-006860-a3b8hyyr	664	21	well	well	RB
cord-006860-a3b8hyyr	664	22	as	as	IN
cord-006860-a3b8hyyr	664	23	from	from	IN
cord-006860-a3b8hyyr	664	24	non	non	JJ
cord-006860-a3b8hyyr	664	25	-	-	JJ
cord-006860-a3b8hyyr	664	26	treated	treat	VBN
cord-006860-a3b8hyyr	664	27	individuals	individual	NNS
cord-006860-a3b8hyyr	664	28	.	.	.
cord-006860-a3b8hyyr	665	1	Ratios	ratio	NNS
cord-006860-a3b8hyyr	665	2	above	above	IN
cord-006860-a3b8hyyr	665	3	2.2	2.2	CD
cord-006860-a3b8hyyr	665	4	are	be	VBP
cord-006860-a3b8hyyr	665	5	obtained	obtain	VBN
cord-006860-a3b8hyyr	665	6	in	in	IN
cord-006860-a3b8hyyr	665	7	normal	normal	JJ
cord-006860-a3b8hyyr	665	8	genotype	genotype	NN
cord-006860-a3b8hyyr	665	9	plasmas	plasma	NNS
cord-006860-a3b8hyyr	665	10	,	,	,
cord-006860-a3b8hyyr	665	11	whereas	whereas	IN
cord-006860-a3b8hyyr	665	12	heterozygotes	heterozygote	NNS
cord-006860-a3b8hyyr	665	13	for	for	IN
cord-006860-a3b8hyyr	665	14	the	the	DT
cord-006860-a3b8hyyr	665	15	mutation	mutation	NN
cord-006860-a3b8hyyr	665	16	yield	yield	NN
cord-006860-a3b8hyyr	665	17	ratios	ratio	NNS
cord-006860-a3b8hyyr	665	18	in	in	IN
cord-006860-a3b8hyyr	665	19	the	the	DT
cord-006860-a3b8hyyr	665	20	range	range	NN
cord-006860-a3b8hyyr	665	21	1.6	1.6	CD
cord-006860-a3b8hyyr	665	22	-	-	SYM
cord-006860-a3b8hyyr	665	23	2.0	2.0	CD
cord-006860-a3b8hyyr	665	24	.	.	.
cord-006860-a3b8hyyr	666	1	The	the	DT
cord-006860-a3b8hyyr	666	2	basal	basal	NN
cord-006860-a3b8hyyr	666	3	APT	APT	NNP
cord-006860-a3b8hyyr	666	4	times	time	NNS
cord-006860-a3b8hyyr	666	5	for	for	IN
cord-006860-a3b8hyyr	666	6	15	15	CD
cord-006860-a3b8hyyr	666	7	OACplasmas	OACplasmas	NNP
cord-006860-a3b8hyyr	666	8	with	with	IN
cord-006860-a3b8hyyr	666	9	widely	widely	RB
cord-006860-a3b8hyyr	666	10	spread	spread	VBN
cord-006860-a3b8hyyr	666	11	INR	INR	NNP
cord-006860-a3b8hyyr	666	12	-	-	HYPH
cord-006860-a3b8hyyr	666	13	values	value	NNS
cord-006860-a3b8hyyr	666	14	were	be	VBD
cord-006860-a3b8hyyr	666	15	reestablished	reestablish	VBN
cord-006860-a3b8hyyr	666	16	into	into	IN
cord-006860-a3b8hyyr	666	17	the	the	DT
cord-006860-a3b8hyyr	666	18	normal	normal	JJ
cord-006860-a3b8hyyr	666	19	range	range	NN
cord-006860-a3b8hyyr	666	20	.	.	.
cord-006860-a3b8hyyr	667	1	.The	.The	.
cord-006860-a3b8hyyr	668	1	stability	stability	NN
cord-006860-a3b8hyyr	668	2	of	of	IN
cord-006860-a3b8hyyr	668	3	the	the	DT
cord-006860-a3b8hyyr	668	4	reconstituted	reconstitute	VBN
cord-006860-a3b8hyyr	668	5	FV	fv	NN
cord-006860-a3b8hyyr	668	6	-	-	HYPH
cord-006860-a3b8hyyr	668	7	deficient	deficient	JJ
cord-006860-a3b8hyyr	668	8	plasma	plasma	NN
cord-006860-a3b8hyyr	668	9	was	be	VBD
cord-006860-a3b8hyyr	668	10	found	find	VBN
cord-006860-a3b8hyyr	668	11	to	to	TO
cord-006860-a3b8hyyr	668	12	be	be	VB
cord-006860-a3b8hyyr	668	13	'	'	``
cord-006860-a3b8hyyr	668	14	at	at	RB
cord-006860-a3b8hyyr	668	15	least	least	JJS
cord-006860-a3b8hyyr	668	16	3	3	CD
cord-006860-a3b8hyyr	668	17	hours	hour	NNS
cord-006860-a3b8hyyr	668	18	at	at	IN
cord-006860-a3b8hyyr	668	19	room	room	NN
cord-006860-a3b8hyyr	668	20	tempetature	tempetature	NN
cord-006860-a3b8hyyr	668	21	,	,	,
cord-006860-a3b8hyyr	668	22	indicating	indicate	VBG
cord-006860-a3b8hyyr	668	23	its	-PRON-	PRP$
cord-006860-a3b8hyyr	668	24	suitability	suitability	NN
cord-006860-a3b8hyyr	668	25	for	for	IN
cord-006860-a3b8hyyr	668	26	.routin.e	.routin.e	.
cord-006860-a3b8hyyr	669	1	u.~.	u.~.	JJ
cord-006860-a3b8hyyr	670	1	F	F	NNP
cord-006860-a3b8hyyr	670	2	.u~	.u~	NNP
cord-006860-a3b8hyyr	670	3	.e	.e	.
cord-006860-a3b8hyyr	671	1	~mv~.	~mv~.	NFP
cord-006860-a3b8hyyr	671	2	,	,	,
cord-006860-a3b8hyyr	671	3	the	the	DT
cord-006860-a3b8hyyr	671	4	influence	influence	NN
cord-006860-a3b8hyyr	671	5	of	of	IN
cord-006860-a3b8hyyr	671	6	preanalytical	preanalytical	JJ
cord-006860-a3b8hyyr	671	7	procedures	procedure	NNS
cord-006860-a3b8hyyr	671	8	is	be	VBZ
cord-006860-a3b8hyyr	671	9	rmm~	rmm~	CD
cord-006860-a3b8hyyr	671	10	single	single	JJ
cord-006860-a3b8hyyr	671	11	or	or	CC
cord-006860-a3b8hyyr	671	12	double	double	JJ
cord-006860-a3b8hyyr	671	13	cenuifugation	cenuifugation	NN
cord-006860-a3b8hyyr	671	14	as	as	RB
cord-006860-a3b8hyyr	671	15	well	well	RB
cord-006860-a3b8hyyr	671	16	as	as	IN
cord-006860-a3b8hyyr	671	17	freezing	freezing	NN
cord-006860-a3b8hyyr	671	18	of	of	IN
cord-006860-a3b8hyyr	671	19	samples	sample	NNS
cord-006860-a3b8hyyr	671	20	do	do	VBP
cord-006860-a3b8hyyr	671	21	not	not	RB
cord-006860-a3b8hyyr	671	22	alter	alter	VB
cord-006860-a3b8hyyr	671	23	the	the	DT
cord-006860-a3b8hyyr	671	24	APC	APC	NNP
cord-006860-a3b8hyyr	671	25	ratios	ratio	NNS
cord-006860-a3b8hyyr	671	26	to	to	IN
cord-006860-a3b8hyyr	671	27	any	any	DT
cord-006860-a3b8hyyr	671	28	significant	significant	JJ
cord-006860-a3b8hyyr	671	29	extent	extent	NN
cord-006860-a3b8hyyr	671	30	.	.	.
cord-006860-a3b8hyyr	672	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	672	2	results	result	NNS
cord-006860-a3b8hyyr	672	3	prove	prove	VBP
cord-006860-a3b8hyyr	672	4	the	the	DT
cord-006860-a3b8hyyr	672	5	usefulness	usefulness	NN
cord-006860-a3b8hyyr	672	6	of	of	IN
cord-006860-a3b8hyyr	672	7	the	the	DT
cord-006860-a3b8hyyr	672	8	modified	modify	VBN
cord-006860-a3b8hyyr	672	9	COATEST	COATEST	NNP
cord-006860-a3b8hyyr	672	10	APC	APC	NNP
cord-006860-a3b8hyyr	672	11	Resistance	Resistance	NNP
cord-006860-a3b8hyyr	672	12	kit	kit	NN
cord-006860-a3b8hyyr	672	13	method	method	NN
cord-006860-a3b8hyyr	672	14	as	as	IN
cord-006860-a3b8hyyr	672	15	a	a	DT
cord-006860-a3b8hyyr	672	16	reliable	reliable	JJ
cord-006860-a3b8hyyr	672	17	,	,	,
cord-006860-a3b8hyyr	672	18	simple	simple	JJ
cord-006860-a3b8hyyr	672	19	and	and	CC
cord-006860-a3b8hyyr	672	20	rapid	rapid	JJ
cord-006860-a3b8hyyr	672	21	tool	tool	NN
cord-006860-a3b8hyyr	672	22	when	when	WRB
cord-006860-a3b8hyyr	672	23	screening	screen	VBG
cord-006860-a3b8hyyr	672	24	for	for	IN
cord-006860-a3b8hyyr	672	25	the	the	DT
cord-006860-a3b8hyyr	672	26	presence	presence	NN
cord-006860-a3b8hyyr	672	27	of	of	IN
cord-006860-a3b8hyyr	672	28	the	the	DT
cord-006860-a3b8hyyr	672	29	FV	FV	NNP
cord-006860-a3b8hyyr	672	30	Q506	Q506	NNP
cord-006860-a3b8hyyr	672	31	mutation	mutation	NN
cord-006860-a3b8hyyr	672	32	.	.	.
cord-006860-a3b8hyyr	673	1	Hereditary	hereditary	JJ
cord-006860-a3b8hyyr	673	2	resistance	resistance	NN
cord-006860-a3b8hyyr	673	3	against	against	IN
cord-006860-a3b8hyyr	673	4	the	the	DT
cord-006860-a3b8hyyr	673	5	anticoagulatory	anticoagulatory	NNP
cord-006860-a3b8hyyr	673	6	action	action	NN
cord-006860-a3b8hyyr	673	7	of	of	IN
cord-006860-a3b8hyyr	673	8	activated	activate	VBN
cord-006860-a3b8hyyr	673	9	protein	protein	NN
cord-006860-a3b8hyyr	673	10	C	C	NNP
cord-006860-a3b8hyyr	673	11	(	(	-LRB-
cord-006860-a3b8hyyr	673	12	APC	APC	NNP
cord-006860-a3b8hyyr	673	13	-	-	HYPH
cord-006860-a3b8hyyr	673	14	resistance	resistance	NN
cord-006860-a3b8hyyr	673	15	,	,	,
cord-006860-a3b8hyyr	673	16	APCR	APCR	NNP
cord-006860-a3b8hyyr	673	17	)	)	-RRB-
cord-006860-a3b8hyyr	673	18	which	which	WDT
cord-006860-a3b8hyyr	673	19	was	be	VBD
cord-006860-a3b8hyyr	673	20	first	first	RB
cord-006860-a3b8hyyr	673	21	described	describe	VBN
cord-006860-a3b8hyyr	673	22	by	by	IN
cord-006860-a3b8hyyr	673	23	Dahlb	Dahlb	NNP
cord-006860-a3b8hyyr	673	24	~	~	NFP
cord-006860-a3b8hyyr	673	25	ick	ick	UH
cord-006860-a3b8hyyr	673	26	et	et	NNP
cord-006860-a3b8hyyr	673	27	al	al	NNP
cord-006860-a3b8hyyr	673	28	.	.	.
cord-006860-a3b8hyyr	674	1	(	(	-LRB-
cord-006860-a3b8hyyr	674	2	PNAS	PNAS	NNP
cord-006860-a3b8hyyr	674	3	,	,	,
cord-006860-a3b8hyyr	674	4	90:1004	90:1004	CD
cord-006860-a3b8hyyr	674	5	,	,	,
cord-006860-a3b8hyyr	674	6	1993	1993	CD
cord-006860-a3b8hyyr	674	7	was	be	VBD
cord-006860-a3b8hyyr	674	8	identified	identify	VBN
cord-006860-a3b8hyyr	674	9	as	as	IN
cord-006860-a3b8hyyr	674	10	a	a	DT
cord-006860-a3b8hyyr	674	11	possible	possible	JJ
cord-006860-a3b8hyyr	674	12	new	new	JJ
cord-006860-a3b8hyyr	674	13	thrombophilic	thrombophilic	JJ
cord-006860-a3b8hyyr	674	14	factor	factor	NN
cord-006860-a3b8hyyr	674	15	in	in	IN
cord-006860-a3b8hyyr	674	16	a	a	DT
cord-006860-a3b8hyyr	674	17	high	high	JJ
cord-006860-a3b8hyyr	674	18	percentage	percentage	NN
cord-006860-a3b8hyyr	674	19	(	(	-LRB-
cord-006860-a3b8hyyr	674	20	17	17	CD
cord-006860-a3b8hyyr	674	21	-	-	SYM
cord-006860-a3b8hyyr	674	22	60	60	CD
cord-006860-a3b8hyyr	674	23	%	%	NN
cord-006860-a3b8hyyr	674	24	)	)	-RRB-
cord-006860-a3b8hyyr	674	25	of	of	IN
cord-006860-a3b8hyyr	674	26	young	young	JJ
cord-006860-a3b8hyyr	674	27	adults	adult	NNS
cord-006860-a3b8hyyr	674	28	with	with	IN
cord-006860-a3b8hyyr	674	29	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	674	30	events	event	NNS
cord-006860-a3b8hyyr	674	31	.	.	.
cord-006860-a3b8hyyr	675	1	A	a	DT
cord-006860-a3b8hyyr	675	2	single	single	JJ
cord-006860-a3b8hyyr	675	3	missense	missense	NN
cord-006860-a3b8hyyr	675	4	mutation	mutation	NN
cord-006860-a3b8hyyr	675	5	(	(	-LRB-
cord-006860-a3b8hyyr	675	6	R506Q	R506Q	NNP
cord-006860-a3b8hyyr	675	7	)	)	-RRB-
cord-006860-a3b8hyyr	675	8	due	due	IN
cord-006860-a3b8hyyr	675	9	to	to	IN
cord-006860-a3b8hyyr	675	10	a	a	DT
cord-006860-a3b8hyyr	675	11	G	g	NN
cord-006860-a3b8hyyr	675	12	/	/	SYM
cord-006860-a3b8hyyr	675	13	A	a	DT
cord-006860-a3b8hyyr	675	14	transition	transition	NN
cord-006860-a3b8hyyr	675	15	(	(	-LRB-
cord-006860-a3b8hyyr	675	16	G1691A	G1691A	NNP
cord-006860-a3b8hyyr	675	17	)	)	-RRB-
cord-006860-a3b8hyyr	675	18	in	in	IN
cord-006860-a3b8hyyr	675	19	exon	exon	NN
cord-006860-a3b8hyyr	675	20	10	10	CD
cord-006860-a3b8hyyr	675	21	of	of	IN
cord-006860-a3b8hyyr	675	22	the	the	DT
cord-006860-a3b8hyyr	675	23	factor	factor	NN
cord-006860-a3b8hyyr	675	24	V	v	NN
cord-006860-a3b8hyyr	675	25	gene	gene	NN
cord-006860-a3b8hyyr	676	1	(	(	-LRB-
cord-006860-a3b8hyyr	676	2	Bertina	Bertina	NNP
cord-006860-a3b8hyyr	676	3	et	et	NNP
cord-006860-a3b8hyyr	676	4	al	al	NNP
cord-006860-a3b8hyyr	676	5	.	.	.
cord-006860-a3b8hyyr	677	1	,	,	,
cord-006860-a3b8hyyr	677	2	Nature	Nature	NNP
cord-006860-a3b8hyyr	677	3	,	,	,
cord-006860-a3b8hyyr	677	4	369:64	369:64	CD
cord-006860-a3b8hyyr	677	5	,	,	,
cord-006860-a3b8hyyr	677	6	1994	1994	CD
cord-006860-a3b8hyyr	677	7	)	)	-RRB-
cord-006860-a3b8hyyr	677	8	is	be	VBZ
cord-006860-a3b8hyyr	677	9	tightly	tightly	RB
cord-006860-a3b8hyyr	677	10	linked	link	VBN
cord-006860-a3b8hyyr	677	11	with	with	IN
cord-006860-a3b8hyyr	677	12	APCR	APCR	NNP
cord-006860-a3b8hyyr	677	13	and	and	CC
cord-006860-a3b8hyyr	677	14	is	be	VBZ
cord-006860-a3b8hyyr	677	15	regarded	regard	VBN
cord-006860-a3b8hyyr	677	16	as	as	IN
cord-006860-a3b8hyyr	677	17	the	the	DT
cord-006860-a3b8hyyr	677	18	causative	causative	JJ
cord-006860-a3b8hyyr	677	19	molecular	molecular	JJ
cord-006860-a3b8hyyr	677	20	defect	defect	NN
cord-006860-a3b8hyyr	677	21	.	.	.
cord-006860-a3b8hyyr	678	1	Identification	identification	NN
cord-006860-a3b8hyyr	678	2	of	of	IN
cord-006860-a3b8hyyr	678	3	this	this	DT
cord-006860-a3b8hyyr	678	4	mutation	mutation	NN
cord-006860-a3b8hyyr	678	5	by	by	IN
cord-006860-a3b8hyyr	678	6	PCR	PCR	NNP
cord-006860-a3b8hyyr	678	7	-	-	HYPH
cord-006860-a3b8hyyr	678	8	based	base	VBN
cord-006860-a3b8hyyr	678	9	methods	method	NNS
cord-006860-a3b8hyyr	678	10	is	be	VBZ
cord-006860-a3b8hyyr	678	11	easy	easy	JJ
cord-006860-a3b8hyyr	678	12	to	to	TO
cord-006860-a3b8hyyr	678	13	perform	perform	VB
cord-006860-a3b8hyyr	678	14	and	and	CC
cord-006860-a3b8hyyr	678	15	avoids	avoid	VBZ
cord-006860-a3b8hyyr	678	16	preanalytie	preanalytie	NN
cord-006860-a3b8hyyr	678	17	and	and	CC
cord-006860-a3b8hyyr	678	18	analytic	analytic	JJ
cord-006860-a3b8hyyr	678	19	errors	error	NNS
cord-006860-a3b8hyyr	678	20	in	in	IN
cord-006860-a3b8hyyr	678	21	the	the	DT
cord-006860-a3b8hyyr	678	22	eoagulometric	eoagulometric	JJ
cord-006860-a3b8hyyr	678	23	assay	assay	NN
cord-006860-a3b8hyyr	678	24	for	for	IN
cord-006860-a3b8hyyr	678	25	APCR	APCR	NNP
cord-006860-a3b8hyyr	678	26	.	.	.
cord-006860-a3b8hyyr	679	1	Since	since	IN
cord-006860-a3b8hyyr	679	2	the	the	DT
cord-006860-a3b8hyyr	679	3	impact	impact	NN
cord-006860-a3b8hyyr	679	4	of	of	IN
cord-006860-a3b8hyyr	679	5	this	this	DT
cord-006860-a3b8hyyr	679	6	mutation	mutation	NN
cord-006860-a3b8hyyr	679	7	in	in	IN
cord-006860-a3b8hyyr	679	8	children	child	NNS
cord-006860-a3b8hyyr	679	9	with	with	IN
cord-006860-a3b8hyyr	679	10	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	679	11	disease	disease	NN
cord-006860-a3b8hyyr	679	12	has	have	VBZ
cord-006860-a3b8hyyr	679	13	not	not	RB
cord-006860-a3b8hyyr	679	14	been	be	VBN
cord-006860-a3b8hyyr	679	15	determined	determine	VBN
cord-006860-a3b8hyyr	679	16	to	to	IN
cord-006860-a3b8hyyr	679	17	date	date	NN
cord-006860-a3b8hyyr	679	18	,	,	,
cord-006860-a3b8hyyr	679	19	we	-PRON-	PRP
cord-006860-a3b8hyyr	679	20	initiated	initiate	VBD
cord-006860-a3b8hyyr	679	21	a	a	DT
cord-006860-a3b8hyyr	679	22	multi	multi	JJ
cord-006860-a3b8hyyr	679	23	-	-	JJ
cord-006860-a3b8hyyr	679	24	center	center	JJ
cord-006860-a3b8hyyr	679	25	prevalence	prevalence	NN
cord-006860-a3b8hyyr	679	26	study	study	NN
cord-006860-a3b8hyyr	679	27	on	on	IN
cord-006860-a3b8hyyr	679	28	two	two	CD
cord-006860-a3b8hyyr	679	29	pediatric	pediatric	JJ
cord-006860-a3b8hyyr	679	30	populations	population	NNS
cord-006860-a3b8hyyr	679	31	,	,	,
cord-006860-a3b8hyyr	679	32	with	with	IN
cord-006860-a3b8hyyr	679	33	and	and	CC
cord-006860-a3b8hyyr	679	34	without	without	IN
cord-006860-a3b8hyyr	679	35	thromboembolie	thromboembolie	NNP
cord-006860-a3b8hyyr	679	36	events	event	NNS
cord-006860-a3b8hyyr	679	37	.	.	.
cord-006860-a3b8hyyr	680	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	680	2	compared	compare	VBD
cord-006860-a3b8hyyr	680	3	125	125	CD
cord-006860-a3b8hyyr	680	4	pediatric	pediatric	JJ
cord-006860-a3b8hyyr	680	5	patients	patient	NNS
cord-006860-a3b8hyyr	680	6	with	with	IN
cord-006860-a3b8hyyr	680	7	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	680	8	,	,	,
cord-006860-a3b8hyyr	680	9	divided	divide	VBN
cord-006860-a3b8hyyr	680	10	into	into	IN
cord-006860-a3b8hyyr	680	11	3	3	CD
cord-006860-a3b8hyyr	680	12	different	different	JJ
cord-006860-a3b8hyyr	680	13	age	age	NN
cord-006860-a3b8hyyr	680	14	groups	group	NNS
cord-006860-a3b8hyyr	680	15	(	(	-LRB-
cord-006860-a3b8hyyr	680	16	0	0	CD
cord-006860-a3b8hyyr	680	17	to	to	IN
cord-006860-a3b8hyyr	680	18	<	<	XX
cord-006860-a3b8hyyr	680	19	0,5	0,5	CD
cord-006860-a3b8hyyr	680	20	years	year	NNS
cord-006860-a3b8hyyr	680	21	;	;	:
cord-006860-a3b8hyyr	680	22	>	>	XX
cord-006860-a3b8hyyr	680	23	0,5	0,5	CD
cord-006860-a3b8hyyr	680	24	to	to	IN
cord-006860-a3b8hyyr	680	25	<	<	XX
cord-006860-a3b8hyyr	680	26	10	10	CD
cord-006860-a3b8hyyr	680	27	years	year	NNS
cord-006860-a3b8hyyr	680	28	;	;	:
cord-006860-a3b8hyyr	680	29	>	>	XX
cord-006860-a3b8hyyr	680	30	10	10	CD
cord-006860-a3b8hyyr	680	31	to	to	IN
cord-006860-a3b8hyyr	680	32	<	<	XX
cord-006860-a3b8hyyr	680	33	18	18	CD
cord-006860-a3b8hyyr	680	34	years	year	NNS
cord-006860-a3b8hyyr	680	35	)	)	-RRB-
cord-006860-a3b8hyyr	680	36	with	with	IN
cord-006860-a3b8hyyr	680	37	a	a	DT
cord-006860-a3b8hyyr	680	38	normal	normal	JJ
cord-006860-a3b8hyyr	680	39	population	population	NN
cord-006860-a3b8hyyr	680	40	of	of	IN
cord-006860-a3b8hyyr	680	41	159	159	CD
cord-006860-a3b8hyyr	680	42	children	child	NNS
cord-006860-a3b8hyyr	680	43	.	.	.
cord-006860-a3b8hyyr	681	1	The	the	DT
cord-006860-a3b8hyyr	681	2	mutation	mutation	NN
cord-006860-a3b8hyyr	681	3	G1691A	G1691A	NNP
cord-006860-a3b8hyyr	681	4	was	be	VBD
cord-006860-a3b8hyyr	681	5	found	find	VBN
cord-006860-a3b8hyyr	681	6	with	with	IN
cord-006860-a3b8hyyr	681	7	an	an	DT
cord-006860-a3b8hyyr	681	8	unexpected	unexpected	JJ
cord-006860-a3b8hyyr	681	9	high	high	JJ
cord-006860-a3b8hyyr	681	10	prevalenee	prevalenee	NN
cord-006860-a3b8hyyr	681	11	of	of	IN
cord-006860-a3b8hyyr	681	12	12	12	CD
cord-006860-a3b8hyyr	681	13	%	%	NN
cord-006860-a3b8hyyr	681	14	in	in	IN
cord-006860-a3b8hyyr	681	15	our	-PRON-	PRP$
cord-006860-a3b8hyyr	681	16	normal	normal	JJ
cord-006860-a3b8hyyr	681	17	controls	control	NNS
cord-006860-a3b8hyyr	681	18	.	.	.
cord-006860-a3b8hyyr	682	1	However	however	RB
cord-006860-a3b8hyyr	682	2	,	,	,
cord-006860-a3b8hyyr	682	3	the	the	DT
cord-006860-a3b8hyyr	682	4	prevalence	prevalence	NN
cord-006860-a3b8hyyr	682	5	was	be	VBD
cord-006860-a3b8hyyr	682	6	significantly	significantly	RB
cord-006860-a3b8hyyr	682	7	higher	high	JJR
cord-006860-a3b8hyyr	682	8	in	in	IN
cord-006860-a3b8hyyr	682	9	the	the	DT
cord-006860-a3b8hyyr	682	10	age	age	NN
cord-006860-a3b8hyyr	682	11	groups	group	NNS
cord-006860-a3b8hyyr	682	12	:	:	:
cord-006860-a3b8hyyr	682	13	0	0	CD
cord-006860-a3b8hyyr	682	14	to	to	IN
cord-006860-a3b8hyyr	682	15	<	<	XX
cord-006860-a3b8hyyr	682	16	0,5	0,5	CD
cord-006860-a3b8hyyr	682	17	years	year	NNS
cord-006860-a3b8hyyr	682	18	(	(	-LRB-
cord-006860-a3b8hyyr	682	19	25	25	CD
cord-006860-a3b8hyyr	682	20	%	%	NN
cord-006860-a3b8hyyr	682	21	)	)	-RRB-
cord-006860-a3b8hyyr	682	22	and	and	CC
cord-006860-a3b8hyyr	682	23	>	>	XX
cord-006860-a3b8hyyr	682	24	10	10	CD
cord-006860-a3b8hyyr	682	25	to	to	IN
cord-006860-a3b8hyyr	682	26	<	<	XX
cord-006860-a3b8hyyr	682	27	18	18	CD
cord-006860-a3b8hyyr	682	28	years	year	NNS
cord-006860-a3b8hyyr	682	29	(	(	-LRB-
cord-006860-a3b8hyyr	682	30	30	30	CD
cord-006860-a3b8hyyr	682	31	%	%	NN
cord-006860-a3b8hyyr	682	32	)	)	-RRB-
cord-006860-a3b8hyyr	682	33	.	.	.
cord-006860-a3b8hyyr	683	1	In	in	IN
cord-006860-a3b8hyyr	683	2	patients	patient	NNS
cord-006860-a3b8hyyr	683	3	between	between	IN
cord-006860-a3b8hyyr	683	4	>	>	XX
cord-006860-a3b8hyyr	683	5	0,5	0,5	CD
cord-006860-a3b8hyyr	683	6	to	to	IN
cord-006860-a3b8hyyr	683	7	<	<	XX
cord-006860-a3b8hyyr	683	8	10	10	CD
cord-006860-a3b8hyyr	683	9	years	year	NNS
cord-006860-a3b8hyyr	683	10	the	the	DT
cord-006860-a3b8hyyr	683	11	overall	overall	JJ
cord-006860-a3b8hyyr	683	12	prevalence	prevalence	NN
cord-006860-a3b8hyyr	683	13	was	be	VBD
cord-006860-a3b8hyyr	683	14	similar	similar	JJ
cord-006860-a3b8hyyr	683	15	to	to	IN
cord-006860-a3b8hyyr	683	16	the	the	DT
cord-006860-a3b8hyyr	683	17	control	control	NN
cord-006860-a3b8hyyr	683	18	(	(	-LRB-
cord-006860-a3b8hyyr	683	19	13	13	CD
cord-006860-a3b8hyyr	683	20	%	%	NN
cord-006860-a3b8hyyr	683	21	)	)	-RRB-
cord-006860-a3b8hyyr	683	22	.	.	.
cord-006860-a3b8hyyr	684	1	However	however	RB
cord-006860-a3b8hyyr	684	2	in	in	IN
cord-006860-a3b8hyyr	684	3	patients	patient	NNS
cord-006860-a3b8hyyr	684	4	of	of	IN
cord-006860-a3b8hyyr	684	5	this	this	DT
cord-006860-a3b8hyyr	684	6	age	age	NN
cord-006860-a3b8hyyr	684	7	with	with	IN
cord-006860-a3b8hyyr	684	8	spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	684	9	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	684	10	APCR	APCR	NNP
cord-006860-a3b8hyyr	684	11	was	be	VBD
cord-006860-a3b8hyyr	684	12	also	also	RB
cord-006860-a3b8hyyr	684	13	a	a	DT
cord-006860-a3b8hyyr	684	14	significant	significant	JJ
cord-006860-a3b8hyyr	684	15	risk	risk	NN
cord-006860-a3b8hyyr	684	16	factor	factor	NN
cord-006860-a3b8hyyr	684	17	(	(	-LRB-
cord-006860-a3b8hyyr	684	18	29	29	CD
cord-006860-a3b8hyyr	684	19	%	%	NN
cord-006860-a3b8hyyr	684	20	)	)	-RRB-
cord-006860-a3b8hyyr	684	21	.	.	.
cord-006860-a3b8hyyr	685	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	685	2	results	result	NNS
cord-006860-a3b8hyyr	685	3	emphasize	emphasize	VBP
cord-006860-a3b8hyyr	685	4	the	the	DT
cord-006860-a3b8hyyr	685	5	impact	impact	NN
cord-006860-a3b8hyyr	685	6	of	of	IN
cord-006860-a3b8hyyr	685	7	APCR	APCR	NNP
cord-006860-a3b8hyyr	685	8	for	for	IN
cord-006860-a3b8hyyr	685	9	thrombogenesis	thrombogenesis	NN
cord-006860-a3b8hyyr	685	10	in	in	IN
cord-006860-a3b8hyyr	685	11	children	child	NNS
cord-006860-a3b8hyyr	685	12	.	.	.
cord-006860-a3b8hyyr	686	1	However	however	RB
cord-006860-a3b8hyyr	686	2	,	,	,
cord-006860-a3b8hyyr	686	3	the	the	DT
cord-006860-a3b8hyyr	686	4	significance	significance	NN
cord-006860-a3b8hyyr	686	5	is	be	VBZ
cord-006860-a3b8hyyr	686	6	agedependent	agedependent	NN
cord-006860-a3b8hyyr	686	7	and	and	CC
cord-006860-a3b8hyyr	686	8	does	do	VBZ
cord-006860-a3b8hyyr	686	9	possibly	possibly	RB
cord-006860-a3b8hyyr	686	10	reflect	reflect	VB
cord-006860-a3b8hyyr	686	11	the	the	DT
cord-006860-a3b8hyyr	686	12	different	different	JJ
cord-006860-a3b8hyyr	686	13	physiology	physiology	NN
cord-006860-a3b8hyyr	686	14	of	of	IN
cord-006860-a3b8hyyr	686	15	haemostasis	haemostasis	NN
cord-006860-a3b8hyyr	686	16	in	in	IN
cord-006860-a3b8hyyr	686	17	our	-PRON-	PRP$
cord-006860-a3b8hyyr	686	18	three	three	CD
cord-006860-a3b8hyyr	686	19	age	age	NN
cord-006860-a3b8hyyr	686	20	groups	group	NNS
cord-006860-a3b8hyyr	686	21	.	.	.
cord-006860-a3b8hyyr	687	1	Activated	Activated	NNP
cord-006860-a3b8hyyr	687	2	Protein	Protein	NNP
cord-006860-a3b8hyyr	687	3	C	C	NNP
cord-006860-a3b8hyyr	687	4	(	(	-LRB-
cord-006860-a3b8hyyr	687	5	APC)-Resistanec	apc)-resistanec	DT
cord-006860-a3b8hyyr	687	6	is	be	VBZ
cord-006860-a3b8hyyr	687	7	a	a	DT
cord-006860-a3b8hyyr	687	8	newly	newly	RB
cord-006860-a3b8hyyr	687	9	reeognised	reeognise	VBN
cord-006860-a3b8hyyr	687	10	risk	risk	NN
cord-006860-a3b8hyyr	687	11	factor	factor	NN
cord-006860-a3b8hyyr	687	12	for	for	IN
cord-006860-a3b8hyyr	687	13	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	687	14	.	.	.
cord-006860-a3b8hyyr	688	1	In	in	IN
cord-006860-a3b8hyyr	688	2	at	at	RB
cord-006860-a3b8hyyr	688	3	least	least	RBS
cord-006860-a3b8hyyr	688	4	90	90	CD
cord-006860-a3b8hyyr	688	5	%	%	NN
cord-006860-a3b8hyyr	688	6	of	of	IN
cord-006860-a3b8hyyr	688	7	the	the	DT
cord-006860-a3b8hyyr	688	8	cases	case	NNS
cord-006860-a3b8hyyr	688	9	it	-PRON-	PRP
cord-006860-a3b8hyyr	688	10	is	be	VBZ
cord-006860-a3b8hyyr	688	11	caused	cause	VBN
cord-006860-a3b8hyyr	688	12	by	by	IN
cord-006860-a3b8hyyr	688	13	a	a	DT
cord-006860-a3b8hyyr	688	14	single	single	JJ
cord-006860-a3b8hyyr	688	15	point	point	NN
cord-006860-a3b8hyyr	688	16	mutation	mutation	NN
cord-006860-a3b8hyyr	688	17	in	in	IN
cord-006860-a3b8hyyr	688	18	the	the	DT
cord-006860-a3b8hyyr	688	19	factor	factor	NN
cord-006860-a3b8hyyr	688	20	V	v	NN
cord-006860-a3b8hyyr	688	21	gene	gene	NN
cord-006860-a3b8hyyr	688	22	(	(	-LRB-
cord-006860-a3b8hyyr	688	23	G->A	G->A	NNP
cord-006860-a3b8hyyr	688	24	at	at	IN
cord-006860-a3b8hyyr	688	25	nucleotide	nucleotide	JJ
cord-006860-a3b8hyyr	688	26	1691	1691	CD
cord-006860-a3b8hyyr	688	27	)	)	-RRB-
cord-006860-a3b8hyyr	688	28	,	,	,
cord-006860-a3b8hyyr	688	29	which	which	WDT
cord-006860-a3b8hyyr	688	30	predicts	predict	VBZ
cord-006860-a3b8hyyr	688	31	replacement	replacement	NN
cord-006860-a3b8hyyr	688	32	of	of	IN
cord-006860-a3b8hyyr	688	33	Arginin	Arginin	NNP
cord-006860-a3b8hyyr	688	34	506	506	CD
cord-006860-a3b8hyyr	688	35	with	with	IN
cord-006860-a3b8hyyr	688	36	Ghitamin	Ghitamin	NNP
cord-006860-a3b8hyyr	688	37	.	.	.
cord-006860-a3b8hyyr	689	1	One	one	CD
cord-006860-a3b8hyyr	689	2	of	of	IN
cord-006860-a3b8hyyr	689	3	the	the	DT
cord-006860-a3b8hyyr	689	4	APC	APC	NNP
cord-006860-a3b8hyyr	689	5	cleavage	cleavage	NN
cord-006860-a3b8hyyr	689	6	sites	site	NNS
cord-006860-a3b8hyyr	689	7	in	in	IN
cord-006860-a3b8hyyr	689	8	factor	factor	NN
cord-006860-a3b8hyyr	689	9	Va	Va	NNP
cord-006860-a3b8hyyr	689	10	is	be	VBZ
cord-006860-a3b8hyyr	689	11	located	locate	VBN
cord-006860-a3b8hyyr	689	12	C	c	NN
cord-006860-a3b8hyyr	689	13	-	-	HYPH
cord-006860-a3b8hyyr	689	14	terminal	terminal	NN
cord-006860-a3b8hyyr	689	15	of	of	IN
cord-006860-a3b8hyyr	689	16	Arginin	Arginin	NNP
cord-006860-a3b8hyyr	689	17	506	506	CD
cord-006860-a3b8hyyr	689	18	,	,	,
cord-006860-a3b8hyyr	689	19	and	and	CC
cord-006860-a3b8hyyr	689	20	mutated	mutated	JJ
cord-006860-a3b8hyyr	689	21	factor	factor	NN
cord-006860-a3b8hyyr	689	22	Va	Va	NNP
cord-006860-a3b8hyyr	689	23	(	(	-LRB-
cord-006860-a3b8hyyr	689	24	Factor	factor	NN
cord-006860-a3b8hyyr	689	25	V	V	NNP
cord-006860-a3b8hyyr	689	26	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	689	27	)	)	-RRB-
cord-006860-a3b8hyyr	689	28	is	be	VBZ
cord-006860-a3b8hyyr	689	29	resistant	resistant	JJ
cord-006860-a3b8hyyr	689	30	to	to	IN
cord-006860-a3b8hyyr	689	31	APC	APC	NNP
cord-006860-a3b8hyyr	689	32	-	-	HYPH
cord-006860-a3b8hyyr	689	33	mediated	mediate	VBN
cord-006860-a3b8hyyr	689	34	inactivation	inactivation	NN
cord-006860-a3b8hyyr	689	35	.	.	.
cord-006860-a3b8hyyr	690	1	From	from	IN
cord-006860-a3b8hyyr	690	2	epidemiologic	epidemiologic	JJ
cord-006860-a3b8hyyr	690	3	studies	study	NNS
cord-006860-a3b8hyyr	690	4	it	-PRON-	PRP
cord-006860-a3b8hyyr	690	5	is	be	VBZ
cord-006860-a3b8hyyr	690	6	known	know	VBN
cord-006860-a3b8hyyr	690	7	,	,	,
cord-006860-a3b8hyyr	690	8	that	that	IN
cord-006860-a3b8hyyr	690	9	this	this	DT
cord-006860-a3b8hyyr	690	10	abnormality	abnormality	NN
cord-006860-a3b8hyyr	690	11	can	can	MD
cord-006860-a3b8hyyr	690	12	be	be	VB
cord-006860-a3b8hyyr	690	13	found	find	VBN
cord-006860-a3b8hyyr	690	14	in	in	IN
cord-006860-a3b8hyyr	690	15	about	about	RB
cord-006860-a3b8hyyr	690	16	one	one	CD
cord-006860-a3b8hyyr	690	17	third	third	NN
cord-006860-a3b8hyyr	690	18	of	of	IN
cord-006860-a3b8hyyr	690	19	patients	patient	NNS
cord-006860-a3b8hyyr	690	20	with	with	IN
cord-006860-a3b8hyyr	690	21	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	690	22	.	.	.
cord-006860-a3b8hyyr	691	1	APC	APC	NNP
cord-006860-a3b8hyyr	691	2	-	-	HYPH
cord-006860-a3b8hyyr	691	3	Resistance	Resistance	NNP
cord-006860-a3b8hyyr	691	4	is	be	VBZ
cord-006860-a3b8hyyr	691	5	a	a	DT
cord-006860-a3b8hyyr	691	6	major	major	JJ
cord-006860-a3b8hyyr	691	7	basis	basis	NN
cord-006860-a3b8hyyr	691	8	for	for	IN
cord-006860-a3b8hyyr	691	9	venous	venous	JJ
cord-006860-a3b8hyyr	691	10	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	691	11	and	and	CC
cord-006860-a3b8hyyr	691	12	is	be	VBZ
cord-006860-a3b8hyyr	691	13	prevalent	prevalent	JJ
cord-006860-a3b8hyyr	691	14	in	in	IN
cord-006860-a3b8hyyr	691	15	about	about	RB
cord-006860-a3b8hyyr	691	16	5.10	5.10	CD
cord-006860-a3b8hyyr	691	17	%	%	NN
cord-006860-a3b8hyyr	691	18	of	of	IN
cord-006860-a3b8hyyr	691	19	the	the	DT
cord-006860-a3b8hyyr	691	20	general	general	JJ
cord-006860-a3b8hyyr	691	21	caucasian	caucasian	JJ
cord-006860-a3b8hyyr	691	22	population	population	NN
cord-006860-a3b8hyyr	691	23	.	.	.
cord-006860-a3b8hyyr	692	1	Recurrent	recurrent	JJ
cord-006860-a3b8hyyr	692	2	spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	692	3	abortion	abortion	NN
cord-006860-a3b8hyyr	692	4	(	(	-LRB-
cord-006860-a3b8hyyr	692	5	RSA	rsa	NN
cord-006860-a3b8hyyr	692	6	)	)	-RRB-
cord-006860-a3b8hyyr	692	7	affects	affect	VBZ
cord-006860-a3b8hyyr	692	8	1	1	CD
cord-006860-a3b8hyyr	692	9	-	-	SYM
cord-006860-a3b8hyyr	692	10	5	5	CD
cord-006860-a3b8hyyr	692	11	%	%	NN
cord-006860-a3b8hyyr	692	12	of	of	IN
cord-006860-a3b8hyyr	692	13	couples	couple	NNS
cord-006860-a3b8hyyr	692	14	and	and	CC
cord-006860-a3b8hyyr	692	15	represents	represent	VBZ
cord-006860-a3b8hyyr	692	16	a	a	DT
cord-006860-a3b8hyyr	692	17	major	major	JJ
cord-006860-a3b8hyyr	692	18	concern	concern	NN
cord-006860-a3b8hyyr	692	19	for	for	IN
cord-006860-a3b8hyyr	692	20	reproductive	reproductive	JJ
cord-006860-a3b8hyyr	692	21	medicine	medicine	NN
cord-006860-a3b8hyyr	692	22	.	.	.
cord-006860-a3b8hyyr	693	1	In	in	IN
cord-006860-a3b8hyyr	693	2	spite	spite	NN
cord-006860-a3b8hyyr	693	3	of	of	IN
cord-006860-a3b8hyyr	693	4	extensive	extensive	JJ
cord-006860-a3b8hyyr	693	5	endocrine	endocrine	NN
cord-006860-a3b8hyyr	693	6	,	,	,
cord-006860-a3b8hyyr	693	7	genetic	genetic	JJ
cord-006860-a3b8hyyr	693	8	,	,	,
cord-006860-a3b8hyyr	693	9	serologic	serologic	JJ
cord-006860-a3b8hyyr	693	10	and	and	CC
cord-006860-a3b8hyyr	693	11	anatomic	anatomic	JJ
cord-006860-a3b8hyyr	693	12	evaluation	evaluation	NN
cord-006860-a3b8hyyr	693	13	some	some	DT
cord-006860-a3b8hyyr	693	14	30	30	CD
cord-006860-a3b8hyyr	693	15	-	-	SYM
cord-006860-a3b8hyyr	693	16	40	40	CD
cord-006860-a3b8hyyr	693	17	%	%	NN
cord-006860-a3b8hyyr	693	18	of	of	IN
cord-006860-a3b8hyyr	693	19	RSA	RSA	NNP
cord-006860-a3b8hyyr	693	20	women	woman	NNS
cord-006860-a3b8hyyr	693	21	remain	remain	VBP
cord-006860-a3b8hyyr	693	22	unexplained	unexplained	JJ
cord-006860-a3b8hyyr	693	23	.	.	.
cord-006860-a3b8hyyr	694	1	A	a	DT
cord-006860-a3b8hyyr	694	2	frequent	frequent	JJ
cord-006860-a3b8hyyr	694	3	morphologic	morphologic	JJ
cord-006860-a3b8hyyr	694	4	finding	finding	NN
cord-006860-a3b8hyyr	694	5	in	in	IN
cord-006860-a3b8hyyr	694	6	placentae	placentae	NN
cord-006860-a3b8hyyr	694	7	of	of	IN
cord-006860-a3b8hyyr	694	8	aborted	aborted	JJ
cord-006860-a3b8hyyr	694	9	pregnancies	pregnancy	NNS
cord-006860-a3b8hyyr	694	10	is	be	VBZ
cord-006860-a3b8hyyr	694	11	an	an	DT
cord-006860-a3b8hyyr	694	12	increase	increase	NN
cord-006860-a3b8hyyr	694	13	of	of	IN
cord-006860-a3b8hyyr	694	14	fibrin	fibrin	NN
cord-006860-a3b8hyyr	694	15	deposition	deposition	NN
cord-006860-a3b8hyyr	694	16	within	within	IN
cord-006860-a3b8hyyr	694	17	the	the	DT
cord-006860-a3b8hyyr	694	18	intervitlous	intervitlous	JJ
cord-006860-a3b8hyyr	694	19	space	space	NN
cord-006860-a3b8hyyr	694	20	.	.	.
cord-006860-a3b8hyyr	695	1	Because	because	IN
cord-006860-a3b8hyyr	695	2	of	of	IN
cord-006860-a3b8hyyr	695	3	these	these	DT
cord-006860-a3b8hyyr	695	4	findings	finding	NNS
cord-006860-a3b8hyyr	695	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	695	6	studied	study	VBD
cord-006860-a3b8hyyr	695	7	the	the	DT
cord-006860-a3b8hyyr	695	8	prevalence	prevalence	NN
cord-006860-a3b8hyyr	695	9	of	of	IN
cord-006860-a3b8hyyr	695	10	APC	APC	NNP
cord-006860-a3b8hyyr	695	11	-	-	HYPH
cord-006860-a3b8hyyr	695	12	Resistance	Resistance	NNP
cord-006860-a3b8hyyr	695	13	in	in	IN
cord-006860-a3b8hyyr	695	14	women	woman	NNS
cord-006860-a3b8hyyr	695	15	with	with	IN
cord-006860-a3b8hyyr	695	16	RSA	RSA	NNP
cord-006860-a3b8hyyr	695	17	(	(	-LRB-
cord-006860-a3b8hyyr	695	18	more	more	JJR
cord-006860-a3b8hyyr	695	19	than	than	IN
cord-006860-a3b8hyyr	695	20	3	3	CD
cord-006860-a3b8hyyr	695	21	miscarriages	miscarriage	NNS
cord-006860-a3b8hyyr	695	22	)	)	-RRB-
cord-006860-a3b8hyyr	695	23	of	of	IN
cord-006860-a3b8hyyr	695	24	unknown	unknown	JJ
cord-006860-a3b8hyyr	695	25	origin	origin	NN
cord-006860-a3b8hyyr	695	26	.	.	.
cord-006860-a3b8hyyr	696	1	In	in	IN
cord-006860-a3b8hyyr	696	2	2	2	CD
cord-006860-a3b8hyyr	696	3	of	of	IN
cord-006860-a3b8hyyr	696	4	35	35	CD
cord-006860-a3b8hyyr	696	5	cases	case	NNS
cord-006860-a3b8hyyr	696	6	we	-PRON-	PRP
cord-006860-a3b8hyyr	696	7	found	find	VBD
cord-006860-a3b8hyyr	696	8	a	a	DT
cord-006860-a3b8hyyr	696	9	pathologic	pathologic	JJ
cord-006860-a3b8hyyr	696	10	APC	APC	NNP
cord-006860-a3b8hyyr	696	11	-	-	HYPH
cord-006860-a3b8hyyr	696	12	Resistance	Resistance	NNP
cord-006860-a3b8hyyr	696	13	,	,	,
cord-006860-a3b8hyyr	696	14	both	both	DT
cord-006860-a3b8hyyr	696	15	patients	patient	NNS
cord-006860-a3b8hyyr	696	16	had	have	VBD
cord-006860-a3b8hyyr	696	17	a	a	DT
cord-006860-a3b8hyyr	696	18	history	history	NN
cord-006860-a3b8hyyr	696	19	of	of	IN
cord-006860-a3b8hyyr	696	20	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	696	21	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	696	22	and	and	CC
cord-006860-a3b8hyyr	696	23	were	be	VBD
cord-006860-a3b8hyyr	696	24	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	696	25	for	for	IN
cord-006860-a3b8hyyr	696	26	Factor	Factor	NNP
cord-006860-a3b8hyyr	696	27	V	V	NNP
cord-006860-a3b8hyyr	696	28	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	696	29	.	.	.
cord-006860-a3b8hyyr	697	1	The	the	DT
cord-006860-a3b8hyyr	697	2	prevalance	prevalance	NN
cord-006860-a3b8hyyr	697	3	of	of	IN
cord-006860-a3b8hyyr	697	4	APC	APC	NNP
cord-006860-a3b8hyyr	697	5	-	-	HYPH
cord-006860-a3b8hyyr	697	6	Resistance	Resistance	NNP
cord-006860-a3b8hyyr	697	7	is	be	VBZ
cord-006860-a3b8hyyr	697	8	5,7	5,7	CD
cord-006860-a3b8hyyr	697	9	%	%	NN
cord-006860-a3b8hyyr	697	10	and	and	CC
cord-006860-a3b8hyyr	697	11	thus	thus	RB
cord-006860-a3b8hyyr	697	12	equals	equal	VBZ
cord-006860-a3b8hyyr	697	13	the	the	DT
cord-006860-a3b8hyyr	697	14	prevalence	prevalence	NN
cord-006860-a3b8hyyr	697	15	in	in	IN
cord-006860-a3b8hyyr	697	16	the	the	DT
cord-006860-a3b8hyyr	697	17	general	general	JJ
cord-006860-a3b8hyyr	697	18	population	population	NN
cord-006860-a3b8hyyr	697	19	.	.	.
cord-006860-a3b8hyyr	698	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	698	2	data	datum	NNS
cord-006860-a3b8hyyr	698	3	do	do	VBP
cord-006860-a3b8hyyr	698	4	not	not	RB
cord-006860-a3b8hyyr	698	5	support	support	VB
cord-006860-a3b8hyyr	698	6	the	the	DT
cord-006860-a3b8hyyr	698	7	hypothesis	hypothesis	NN
cord-006860-a3b8hyyr	698	8	that	that	IN
cord-006860-a3b8hyyr	698	9	APC	APC	NNP
cord-006860-a3b8hyyr	698	10	-	-	HYPH
cord-006860-a3b8hyyr	698	11	Resistanee	Resistanee	NNP
cord-006860-a3b8hyyr	698	12	is	be	VBZ
cord-006860-a3b8hyyr	698	13	a	a	DT
cord-006860-a3b8hyyr	698	14	risk	risk	NN
cord-006860-a3b8hyyr	698	15	factor	factor	NN
cord-006860-a3b8hyyr	698	16	for	for	IN
cord-006860-a3b8hyyr	698	17	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	698	18	spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	698	19	abortion	abortion	NN
cord-006860-a3b8hyyr	698	20	.	.	.
cord-006860-a3b8hyyr	699	1	H	H	NNP
cord-006860-a3b8hyyr	699	2	~	~	NFP
cord-006860-a3b8hyyr	699	3	matologisches	matologisches	NNP
cord-006860-a3b8hyyr	699	4	Zentrallabor	Zentrallabor	NNP
cord-006860-a3b8hyyr	699	5	der	der	NNP
cord-006860-a3b8hyyr	699	6	Universit	Universit	NNP
cord-006860-a3b8hyyr	700	1	~t	~t	NNP
cord-006860-a3b8hyyr	700	2	,	,	,
cord-006860-a3b8hyyr	700	3	Inselspital	Inselspital	NNP
cord-006860-a3b8hyyr	700	4	,	,	,
cord-006860-a3b8hyyr	700	5	3010	3010	CD
cord-006860-a3b8hyyr	700	6	Bern	Bern	NNP
cord-006860-a3b8hyyr	700	7	Resistance	Resistance	NNP
cord-006860-a3b8hyyr	700	8	to	to	IN
cord-006860-a3b8hyyr	700	9	activated	activate	VBN
cord-006860-a3b8hyyr	700	10	protein	protein	NN
cord-006860-a3b8hyyr	700	11	C	C	NNP
cord-006860-a3b8hyyr	700	12	(	(	-LRB-
cord-006860-a3b8hyyr	700	13	APC	APC	NNP
cord-006860-a3b8hyyr	700	14	)	)	-RRB-
cord-006860-a3b8hyyr	700	15	due	due	IN
cord-006860-a3b8hyyr	700	16	to	to	IN
cord-006860-a3b8hyyr	700	17	the	the	DT
cord-006860-a3b8hyyr	700	18	mutation	mutation	NN
cord-006860-a3b8hyyr	700	19	506	506	CD
cord-006860-a3b8hyyr	700	20	Arg	arg	NN
cord-006860-a3b8hyyr	700	21	--~	--~	.
cord-006860-a3b8hyyr	701	1	(	(	-LRB-
cord-006860-a3b8hyyr	701	2	]	]	-RRB-
cord-006860-a3b8hyyr	701	3	In	in	IN
cord-006860-a3b8hyyr	701	4	of	of	IN
cord-006860-a3b8hyyr	701	5	factor	factor	NN
cord-006860-a3b8hyyr	701	6	V	v	NN
cord-006860-a3b8hyyr	701	7	(	(	-LRB-
cord-006860-a3b8hyyr	701	8	factor	factor	NN
cord-006860-a3b8hyyr	701	9	V	V	NNP
cord-006860-a3b8hyyr	701	10	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	701	11	mutation	mutation	NN
cord-006860-a3b8hyyr	701	12	)	)	-RRB-
cord-006860-a3b8hyyr	701	13	is	be	VBZ
cord-006860-a3b8hyyr	701	14	the	the	DT
cord-006860-a3b8hyyr	701	15	most	most	RBS
cord-006860-a3b8hyyr	701	16	frequent	frequent	JJ
cord-006860-a3b8hyyr	701	17	hereditary	hereditary	JJ
cord-006860-a3b8hyyr	701	18	thrombophilic	thrombophilic	JJ
cord-006860-a3b8hyyr	701	19	defect	defect	NN
cord-006860-a3b8hyyr	701	20	known	know	VBN
cord-006860-a3b8hyyr	701	21	today	today	NN
cord-006860-a3b8hyyr	701	22	,	,	,
cord-006860-a3b8hyyr	701	23	with	with	IN
cord-006860-a3b8hyyr	701	24	a	a	DT
cord-006860-a3b8hyyr	701	25	prevalence	prevalence	NN
cord-006860-a3b8hyyr	701	26	of	of	IN
cord-006860-a3b8hyyr	701	27	20	20	CD
cord-006860-a3b8hyyr	701	28	-50	-50	NN
cord-006860-a3b8hyyr	701	29	%	%	NN
cord-006860-a3b8hyyr	701	30	in	in	IN
cord-006860-a3b8hyyr	701	31	patients	patient	NNS
cord-006860-a3b8hyyr	701	32	with	with	IN
cord-006860-a3b8hyyr	701	33	idiopathic	idiopathic	JJ
cord-006860-a3b8hyyr	701	34	venous	venous	JJ
cord-006860-a3b8hyyr	701	35	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	701	36	and	and	CC
cord-006860-a3b8hyyr	701	37	of	of	IN
cord-006860-a3b8hyyr	701	38	about	about	RB
cord-006860-a3b8hyyr	701	39	3	3	CD
cord-006860-a3b8hyyr	702	1	-5	-5	NNP
cord-006860-a3b8hyyr	702	2	%	%	NN
cord-006860-a3b8hyyr	702	3	in	in	IN
cord-006860-a3b8hyyr	702	4	the	the	DT
cord-006860-a3b8hyyr	702	5	general	general	JJ
cord-006860-a3b8hyyr	702	6	population	population	NN
cord-006860-a3b8hyyr	702	7	.	.	.
cord-006860-a3b8hyyr	703	1	With	with	IN
cord-006860-a3b8hyyr	703	2	an	an	DT
cord-006860-a3b8hyyr	703	3	allele	allele	NN
cord-006860-a3b8hyyr	703	4	frequency	frequency	NN
cord-006860-a3b8hyyr	703	5	of	of	IN
cord-006860-a3b8hyyr	703	6	2	2	CD
cord-006860-a3b8hyyr	703	7	%	%	NN
cord-006860-a3b8hyyr	703	8	the	the	DT
cord-006860-a3b8hyyr	703	9	expected	expect	VBN
cord-006860-a3b8hyyr	703	10	number	number	NN
cord-006860-a3b8hyyr	703	11	of	of	IN
cord-006860-a3b8hyyr	703	12	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	703	13	individuals	individual	NNS
cord-006860-a3b8hyyr	703	14	is	be	VBZ
cord-006860-a3b8hyyr	703	15	about	about	RB
cord-006860-a3b8hyyr	703	16	4	4	CD
cord-006860-a3b8hyyr	703	17	in	in	IN
cord-006860-a3b8hyyr	703	18	10000	10000	CD
cord-006860-a3b8hyyr	703	19	.	.	.
cord-006860-a3b8hyyr	704	1	Homozygous	Homozygous	NNP
cord-006860-a3b8hyyr	704	2	and	and	CC
cord-006860-a3b8hyyr	704	3	heterozygons	heterozygon	NNS
cord-006860-a3b8hyyr	704	4	individuals	individual	NNS
cord-006860-a3b8hyyr	704	5	differ	differ	VBP
cord-006860-a3b8hyyr	704	6	considerably	considerably	RB
cord-006860-a3b8hyyr	704	7	with	with	IN
cord-006860-a3b8hyyr	704	8	respect	respect	NN
cord-006860-a3b8hyyr	704	9	to	to	IN
cord-006860-a3b8hyyr	704	10	the	the	DT
cord-006860-a3b8hyyr	704	11	relative	relative	JJ
cord-006860-a3b8hyyr	704	12	risk	risk	NN
cord-006860-a3b8hyyr	704	13	of	of	IN
cord-006860-a3b8hyyr	704	14	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	704	15	(	(	-LRB-
cord-006860-a3b8hyyr	704	16	80	80	CD
cord-006860-a3b8hyyr	704	17	-fold	-fold	NN
cord-006860-a3b8hyyr	704	18	versus	versus	IN
cord-006860-a3b8hyyr	704	19	7	7	CD
cord-006860-a3b8hyyr	704	20	-fold	-fold	CD
cord-006860-a3b8hyyr	704	21	)	)	-RRB-
cord-006860-a3b8hyyr	704	22	as	as	RB
cord-006860-a3b8hyyr	704	23	well	well	RB
cord-006860-a3b8hyyr	704	24	as	as	IN
cord-006860-a3b8hyyr	704	25	to	to	IN
cord-006860-a3b8hyyr	704	26	the	the	DT
cord-006860-a3b8hyyr	704	27	age	age	NN
cord-006860-a3b8hyyr	704	28	of	of	IN
cord-006860-a3b8hyyr	704	29	the	the	DT
cord-006860-a3b8hyyr	704	30	first	first	JJ
cord-006860-a3b8hyyr	704	31	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	704	32	event	event	NN
cord-006860-a3b8hyyr	704	33	(	(	-LRB-
cord-006860-a3b8hyyr	704	34	31	31	CD
cord-006860-a3b8hyyr	704	35	versus	versus	IN
cord-006860-a3b8hyyr	704	36	44	44	CD
cord-006860-a3b8hyyr	704	37	years	year	NNS
cord-006860-a3b8hyyr	704	38	)	)	-RRB-
cord-006860-a3b8hyyr	704	39	.	.	.
cord-006860-a3b8hyyr	705	1	Deficiency	deficiency	NN
cord-006860-a3b8hyyr	705	2	of	of	IN
cord-006860-a3b8hyyr	705	3	the	the	DT
cord-006860-a3b8hyyr	705	4	vitamin	vitamin	NN
cord-006860-a3b8hyyr	705	5	K	K	NNP
cord-006860-a3b8hyyr	705	6	dependent	dependent	JJ
cord-006860-a3b8hyyr	705	7	protein	protein	NN
cord-006860-a3b8hyyr	705	8	S	S	NNP
cord-006860-a3b8hyyr	705	9	(	(	-LRB-
cord-006860-a3b8hyyr	705	10	P$	P$	NNP
cord-006860-a3b8hyyr	705	11	)	)	-RRB-
cord-006860-a3b8hyyr	705	12	,	,	,
cord-006860-a3b8hyyr	705	13	an	an	DT
cord-006860-a3b8hyyr	705	14	important	important	JJ
cord-006860-a3b8hyyr	705	15	cofactor	cofactor	NN
cord-006860-a3b8hyyr	705	16	of	of	IN
cord-006860-a3b8hyyr	705	17	APC	APC	NNP
cord-006860-a3b8hyyr	705	18	,	,	,
cord-006860-a3b8hyyr	705	19	is	be	VBZ
cord-006860-a3b8hyyr	705	20	another	another	DT
cord-006860-a3b8hyyr	705	21	hereditary	hereditary	JJ
cord-006860-a3b8hyyr	705	22	thrombophilia	thrombophilia	NN
cord-006860-a3b8hyyr	705	23	which	which	WDT
cord-006860-a3b8hyyr	705	24	is	be	VBZ
cord-006860-a3b8hyyr	705	25	,	,	,
cord-006860-a3b8hyyr	705	26	however	however	RB
cord-006860-a3b8hyyr	705	27	,	,	,
cord-006860-a3b8hyyr	705	28	much	much	RB
cord-006860-a3b8hyyr	705	29	rarer	rare	JJR
cord-006860-a3b8hyyr	705	30	than	than	IN
cord-006860-a3b8hyyr	705	31	APC	APC	NNP
cord-006860-a3b8hyyr	705	32	resistance	resistance	NN
cord-006860-a3b8hyyr	705	33	with	with	IN
cord-006860-a3b8hyyr	705	34	a	a	DT
cord-006860-a3b8hyyr	705	35	prevalence	prevalence	NN
cord-006860-a3b8hyyr	705	36	of	of	IN
cord-006860-a3b8hyyr	705	37	5	5	CD
cord-006860-a3b8hyyr	705	38	to	to	TO
cord-006860-a3b8hyyr	705	39	8	8	CD
cord-006860-a3b8hyyr	705	40	%	%	NN
cord-006860-a3b8hyyr	705	41	in	in	IN
cord-006860-a3b8hyyr	705	42	patients	patient	NNS
cord-006860-a3b8hyyr	705	43	with	with	IN
cord-006860-a3b8hyyr	705	44	venous	venous	JJ
cord-006860-a3b8hyyr	705	45	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	705	46	.	.	.
cord-006860-a3b8hyyr	706	1	Factor	factor	NN
cord-006860-a3b8hyyr	706	2	V	V	NNP
cord-006860-a3b8hyyr	706	3	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	706	4	mutation	mutation	NN
cord-006860-a3b8hyyr	706	5	as	as	RB
cord-006860-a3b8hyyr	706	6	well	well	RB
cord-006860-a3b8hyyr	706	7	as	as	IN
cord-006860-a3b8hyyr	706	8	PS	PS	NNP
cord-006860-a3b8hyyr	706	9	deficiency	deficiency	NN
cord-006860-a3b8hyyr	706	10	are	be	VBP
cord-006860-a3b8hyyr	706	11	associated	associate	VBN
cord-006860-a3b8hyyr	706	12	with	with	IN
cord-006860-a3b8hyyr	706	13	impaired	impaired	JJ
cord-006860-a3b8hyyr	706	14	anticoagulatory	anticoagulatory	NN
cord-006860-a3b8hyyr	706	15	activity	activity	NN
cord-006860-a3b8hyyr	706	16	of	of	IN
cord-006860-a3b8hyyr	706	17	APC	APC	NNP
cord-006860-a3b8hyyr	706	18	,	,	,
cord-006860-a3b8hyyr	706	19	which	which	WDT
cord-006860-a3b8hyyr	706	20	is	be	VBZ
cord-006860-a3b8hyyr	706	21	most	most	RBS
cord-006860-a3b8hyyr	706	22	pronounced	pronounce	VBN
cord-006860-a3b8hyyr	706	23	in	in	IN
cord-006860-a3b8hyyr	706	24	case	case	NN
cord-006860-a3b8hyyr	706	25	of	of	IN
cord-006860-a3b8hyyr	706	26	the	the	DT
cord-006860-a3b8hyyr	706	27	combination	combination	NN
cord-006860-a3b8hyyr	706	28	of	of	IN
cord-006860-a3b8hyyr	706	29	the	the	DT
cord-006860-a3b8hyyr	706	30	two	two	CD
cord-006860-a3b8hyyr	706	31	defects	defect	NNS
cord-006860-a3b8hyyr	706	32	.	.	.
cord-006860-a3b8hyyr	707	1	The	the	DT
cord-006860-a3b8hyyr	707	2	combination	combination	NN
cord-006860-a3b8hyyr	707	3	of	of	IN
cord-006860-a3b8hyyr	707	4	PS	PS	NNP
cord-006860-a3b8hyyr	707	5	deficiency	deficiency	NN
cord-006860-a3b8hyyr	707	6	(	(	-LRB-
cord-006860-a3b8hyyr	707	7	with	with	IN
cord-006860-a3b8hyyr	707	8	an	an	DT
cord-006860-a3b8hyyr	707	9	assumed	assume	VBN
cord-006860-a3b8hyyr	707	10	prevalence	prevalence	NN
cord-006860-a3b8hyyr	707	11	similar	similar	JJ
cord-006860-a3b8hyyr	707	12	to	to	IN
cord-006860-a3b8hyyr	707	13	that	that	DT
cord-006860-a3b8hyyr	707	14	of	of	IN
cord-006860-a3b8hyyr	707	15	PC	pc	NN
cord-006860-a3b8hyyr	707	16	deficiency	deficiency	NN
cord-006860-a3b8hyyr	707	17	)	)	-RRB-
cord-006860-a3b8hyyr	707	18	with	with	IN
cord-006860-a3b8hyyr	707	19	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	707	20	or	or	CC
cord-006860-a3b8hyyr	707	21	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	707	22	APC	APC	NNP
cord-006860-a3b8hyyr	707	23	resistance	resistance	NN
cord-006860-a3b8hyyr	707	24	can	can	MD
cord-006860-a3b8hyyr	707	25	be	be	VB
cord-006860-a3b8hyyr	707	26	expected	expect	VBN
cord-006860-a3b8hyyr	707	27	with	with	IN
cord-006860-a3b8hyyr	707	28	a	a	DT
cord-006860-a3b8hyyr	707	29	probability	probability	NN
cord-006860-a3b8hyyr	707	30	of	of	IN
cord-006860-a3b8hyyr	707	31	1	1	CD
cord-006860-a3b8hyyr	707	32	:	:	:
cord-006860-a3b8hyyr	707	33	~	~	NFP
cord-006860-a3b8hyyr	707	34	5000	5000	CD
cord-006860-a3b8hyyr	707	35	or	or	CC
cord-006860-a3b8hyyr	707	36	1	1	CD
cord-006860-a3b8hyyr	707	37	:	:	:
cord-006860-a3b8hyyr	707	38	~	~	NFP
cord-006860-a3b8hyyr	707	39	500000	500000	CD
cord-006860-a3b8hyyr	707	40	,	,	,
cord-006860-a3b8hyyr	707	41	respectively	respectively	RB
cord-006860-a3b8hyyr	707	42	.	.	.
cord-006860-a3b8hyyr	708	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	708	2	is	be	VBZ
cord-006860-a3b8hyyr	708	3	well	well	RB
cord-006860-a3b8hyyr	708	4	known	know	VBN
cord-006860-a3b8hyyr	708	5	that	that	IN
cord-006860-a3b8hyyr	708	6	PS	PS	NNP
cord-006860-a3b8hyyr	708	7	levels	level	NNS
cord-006860-a3b8hyyr	708	8	decrease	decrease	VBP
cord-006860-a3b8hyyr	708	9	towards	towards	IN
cord-006860-a3b8hyyr	708	10	the	the	DT
cord-006860-a3b8hyyr	708	11	low	low	JJ
cord-006860-a3b8hyyr	708	12	normal	normal	JJ
cord-006860-a3b8hyyr	708	13	or	or	CC
cord-006860-a3b8hyyr	708	14	even	even	RB
cord-006860-a3b8hyyr	708	15	subnormal	subnormal	JJ
cord-006860-a3b8hyyr	708	16	range	range	NN
cord-006860-a3b8hyyr	708	17	during	during	IN
cord-006860-a3b8hyyr	708	18	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	708	19	.	.	.
cord-006860-a3b8hyyr	709	1	Moreovar	Moreovar	NNP
cord-006860-a3b8hyyr	709	2	,	,	,
cord-006860-a3b8hyyr	709	3	there	there	EX
cord-006860-a3b8hyyr	709	4	is	be	VBZ
cord-006860-a3b8hyyr	709	5	increasing	increase	VBG
cord-006860-a3b8hyyr	709	6	evidence	evidence	NN
cord-006860-a3b8hyyr	709	7	that	that	IN
cord-006860-a3b8hyyr	709	8	the	the	DT
cord-006860-a3b8hyyr	709	9	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	709	10	of	of	IN
cord-006860-a3b8hyyr	709	11	plasma	plasma	NN
cord-006860-a3b8hyyr	709	12	to	to	IN
cord-006860-a3b8hyyr	709	13	the	the	DT
cord-006860-a3b8hyyr	709	14	antieoagulatory	antieoagulatory	NNP
cord-006860-a3b8hyyr	709	15	effect	effect	NN
cord-006860-a3b8hyyr	709	16	of	of	IN
cord-006860-a3b8hyyr	709	17	APC	APC	NNP
cord-006860-a3b8hyyr	709	18	decreases	decrease	VBZ
cord-006860-a3b8hyyr	709	19	during	during	IN
cord-006860-a3b8hyyr	709	20	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	709	21	resulting	result	VBG
cord-006860-a3b8hyyr	709	22	in	in	IN
cord-006860-a3b8hyyr	709	23	an	an	DT
cord-006860-a3b8hyyr	709	24	acquired	acquire	VBN
cord-006860-a3b8hyyr	709	25	APC	APC	NNP
cord-006860-a3b8hyyr	709	26	resistance	resistance	NN
cord-006860-a3b8hyyr	709	27	.	.	.
cord-006860-a3b8hyyr	710	1	These	these	DT
cord-006860-a3b8hyyr	710	2	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	710	3	associated	associate	VBD
cord-006860-a3b8hyyr	710	4	effects	effect	NNS
cord-006860-a3b8hyyr	710	5	art	art	NN
cord-006860-a3b8hyyr	710	6	obviously	obviously	RB
cord-006860-a3b8hyyr	710	7	much	much	RB
cord-006860-a3b8hyyr	710	8	more	more	RBR
cord-006860-a3b8hyyr	710	9	relevant	relevant	JJ
cord-006860-a3b8hyyr	710	10	in	in	IN
cord-006860-a3b8hyyr	710	11	case	case	NN
cord-006860-a3b8hyyr	710	12	of	of	IN
cord-006860-a3b8hyyr	710	13	preexisting	preexist	VBG
cord-006860-a3b8hyyr	710	14	PS	PS	NNP
cord-006860-a3b8hyyr	710	15	deficiency	deficiency	NN
cord-006860-a3b8hyyr	710	16	or	or	CC
cord-006860-a3b8hyyr	710	17	APC	APC	NNP
cord-006860-a3b8hyyr	710	18	resistance	resistance	NN
cord-006860-a3b8hyyr	710	19	and	and	CC
cord-006860-a3b8hyyr	710	20	should	should	MD
cord-006860-a3b8hyyr	710	21	contribute	contribute	VB
cord-006860-a3b8hyyr	710	22	to	to	IN
cord-006860-a3b8hyyr	710	23	the	the	DT
cord-006860-a3b8hyyr	710	24	elevated	elevated	JJ
cord-006860-a3b8hyyr	710	25	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	710	26	risk	risk	NN
cord-006860-a3b8hyyr	710	27	during	during	IN
cord-006860-a3b8hyyr	710	28	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	710	29	in	in	IN
cord-006860-a3b8hyyr	710	30	a	a	DT
cord-006860-a3b8hyyr	710	31	subject	subject	NN
cord-006860-a3b8hyyr	710	32	with	with	IN
cord-006860-a3b8hyyr	710	33	either	either	DT
cord-006860-a3b8hyyr	710	34	of	of	IN
cord-006860-a3b8hyyr	710	35	the	the	DT
cord-006860-a3b8hyyr	710	36	two	two	CD
cord-006860-a3b8hyyr	710	37	defects	defect	NNS
cord-006860-a3b8hyyr	710	38	,	,	,
cord-006860-a3b8hyyr	710	39	and	and	CC
cord-006860-a3b8hyyr	710	40	even	even	RB
cord-006860-a3b8hyyr	710	41	more	more	RBR
cord-006860-a3b8hyyr	710	42	so	so	RB
cord-006860-a3b8hyyr	710	43	for	for	IN
cord-006860-a3b8hyyr	710	44	a	a	DT
cord-006860-a3b8hyyr	710	45	woman	woman	NN
cord-006860-a3b8hyyr	710	46	who	who	WP
cord-006860-a3b8hyyr	710	47	suffers	suffer	VBZ
cord-006860-a3b8hyyr	710	48	from	from	IN
cord-006860-a3b8hyyr	710	49	both	both	DT
cord-006860-a3b8hyyr	710	50	defects	defect	NNS
cord-006860-a3b8hyyr	710	51	.	.	.
cord-006860-a3b8hyyr	711	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	711	2	describe	describe	VBP
cord-006860-a3b8hyyr	711	3	a	a	DT
cord-006860-a3b8hyyr	711	4	young	young	JJ
cord-006860-a3b8hyyr	711	5	woman	woman	NN
cord-006860-a3b8hyyr	711	6	with	with	IN
cord-006860-a3b8hyyr	711	7	a	a	DT
cord-006860-a3b8hyyr	711	8	combination	combination	NN
cord-006860-a3b8hyyr	711	9	of	of	IN
cord-006860-a3b8hyyr	711	10	homozygens	homozygens	NNP
cord-006860-a3b8hyyr	711	11	APC	APC	NNP
cord-006860-a3b8hyyr	711	12	resistance	resistance	NN
cord-006860-a3b8hyyr	711	13	(	(	-LRB-
cord-006860-a3b8hyyr	711	14	APC	APC	NNP
cord-006860-a3b8hyyr	711	15	ratio	ratio	NN
cord-006860-a3b8hyyr	711	16	1.10	1.10	CD
cord-006860-a3b8hyyr	711	17	,	,	,
cord-006860-a3b8hyyr	711	18	normal	normal	JJ
cord-006860-a3b8hyyr	711	19	range	range	NN
cord-006860-a3b8hyyr	711	20	:	:	:
cord-006860-a3b8hyyr	711	21	2.02	2.02	CD
cord-006860-a3b8hyyr	711	22	-3.73	-3.73	CD
cord-006860-a3b8hyyr	711	23	)	)	-RRB-
cord-006860-a3b8hyyr	711	24	,	,	,
cord-006860-a3b8hyyr	711	25	pronounced	pronounce	VBD
cord-006860-a3b8hyyr	711	26	PS	PS	NNP
cord-006860-a3b8hyyr	711	27	deficiency	deficiency	NN
cord-006860-a3b8hyyr	711	28	(	(	-LRB-
cord-006860-a3b8hyyr	711	29	free	free	JJ
cord-006860-a3b8hyyr	711	30	PS	PS	NNP
cord-006860-a3b8hyyr	711	31	0.ll	0.ll	CD
cord-006860-a3b8hyyr	712	1	U	U	NNP
cord-006860-a3b8hyyr	712	2	/	/	SYM
cord-006860-a3b8hyyr	712	3	I	I	NNP
cord-006860-a3b8hyyr	712	4	,	,	,
cord-006860-a3b8hyyr	712	5	total	total	JJ
cord-006860-a3b8hyyr	712	6	PS	PS	NNP
cord-006860-a3b8hyyr	712	7	0.30	0.30	CD
cord-006860-a3b8hyyr	712	8	U	U	NNP
cord-006860-a3b8hyyr	712	9	/	/	SYM
cord-006860-a3b8hyyr	712	10	I	-PRON-	PRP
cord-006860-a3b8hyyr	712	11	,	,	,
cord-006860-a3b8hyyr	712	12	normal	normal	JJ
cord-006860-a3b8hyyr	712	13	range	range	NN
cord-006860-a3b8hyyr	712	14	:	:	:
cord-006860-a3b8hyyr	713	1	0.55	0.55	CD
cord-006860-a3b8hyyr	713	2	-1.20	-1.20	CD
cord-006860-a3b8hyyr	713	3	U/1	u/1	NN
cord-006860-a3b8hyyr	713	4	and	and	CC
cord-006860-a3b8hyyr	713	5	0.65	0.65	CD
cord-006860-a3b8hyyr	713	6	-lag	-lag	.
cord-006860-a3b8hyyr	714	1	U	U	NNP
cord-006860-a3b8hyyr	714	2	/	/	SYM
cord-006860-a3b8hyyr	714	3	I	-PRON-	PRP
cord-006860-a3b8hyyr	714	4	,	,	,
cord-006860-a3b8hyyr	714	5	respectively	respectively	RB
cord-006860-a3b8hyyr	714	6	)	)	-RRB-
cord-006860-a3b8hyyr	714	7	and	and	CC
cord-006860-a3b8hyyr	714	8	,	,	,
cord-006860-a3b8hyyr	714	9	moreover	moreover	RB
cord-006860-a3b8hyyr	714	10	,	,	,
cord-006860-a3b8hyyr	714	11	impaired	impair	VBN
cord-006860-a3b8hyyr	714	12	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	714	13	(	(	-LRB-
cord-006860-a3b8hyyr	714	14	no	no	DT
cord-006860-a3b8hyyr	714	15	change	change	NN
cord-006860-a3b8hyyr	714	16	of	of	IN
cord-006860-a3b8hyyr	714	17	euglobulin	euglobulin	NNP
cord-006860-a3b8hyyr	714	18	-lysis	-lysis	NNP
cord-006860-a3b8hyyr	714	19	time	time	NN
cord-006860-a3b8hyyr	714	20	after	after	IN
cord-006860-a3b8hyyr	714	21	10	10	CD
cord-006860-a3b8hyyr	714	22	rain	rain	NN
cord-006860-a3b8hyyr	714	23	venous	venous	JJ
cord-006860-a3b8hyyr	714	24	occlusion	occlusion	NN
cord-006860-a3b8hyyr	714	25	)	)	-RRB-
cord-006860-a3b8hyyr	714	26	who	who	WP
cord-006860-a3b8hyyr	714	27	developed	develop	VBD
cord-006860-a3b8hyyr	714	28	deep	deep	JJ
cord-006860-a3b8hyyr	714	29	vein	vein	NN
cord-006860-a3b8hyyr	714	30	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	714	31	after	after	IN
cord-006860-a3b8hyyr	714	32	cesarean	cesarean	NN
cord-006860-a3b8hyyr	714	33	section	section	NN
cord-006860-a3b8hyyr	714	34	in	in	IN
cord-006860-a3b8hyyr	714	35	her	-PRON-	PRP$
cord-006860-a3b8hyyr	714	36	first	first	JJ
cord-006860-a3b8hyyr	714	37	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	714	38	.	.	.
cord-006860-a3b8hyyr	715	1	Examination	examination	NN
cord-006860-a3b8hyyr	715	2	of	of	IN
cord-006860-a3b8hyyr	715	3	her	-PRON-	PRP$
cord-006860-a3b8hyyr	715	4	familiy	familiy	NN
cord-006860-a3b8hyyr	715	5	showed	show	VBD
cord-006860-a3b8hyyr	715	6	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	715	7	APC	APC	NNP
cord-006860-a3b8hyyr	715	8	resistance	resistance	NN
cord-006860-a3b8hyyr	715	9	in	in	IN
cord-006860-a3b8hyyr	715	10	her	-PRON-	PRP$
cord-006860-a3b8hyyr	715	11	asymptomatie	asymptomatie	NN
cord-006860-a3b8hyyr	715	12	father	father	NN
cord-006860-a3b8hyyr	715	13	(	(	-LRB-
cord-006860-a3b8hyyr	715	14	APC	APC	NNP
cord-006860-a3b8hyyr	715	15	-ratio	-ratio	NNP
cord-006860-a3b8hyyr	715	16	1.99	1.99	CD
cord-006860-a3b8hyyr	715	17	)	)	-RRB-
cord-006860-a3b8hyyr	715	18	,	,	,
cord-006860-a3b8hyyr	715	19	combination	combination	NN
cord-006860-a3b8hyyr	715	20	of	of	IN
cord-006860-a3b8hyyr	715	21	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	715	22	APC	APC	NNP
cord-006860-a3b8hyyr	715	23	resistance	resistance	NN
cord-006860-a3b8hyyr	715	24	(	(	-LRB-
cord-006860-a3b8hyyr	715	25	APC	APC	NNP
cord-006860-a3b8hyyr	715	26	-ratio	-ratio	NNP
cord-006860-a3b8hyyr	715	27	1.60	1.60	CD
cord-006860-a3b8hyyr	715	28	)	)	-RRB-
cord-006860-a3b8hyyr	715	29	and	and	CC
cord-006860-a3b8hyyr	715	30	PS	PS	NNP
cord-006860-a3b8hyyr	715	31	deficiency	deficiency	NN
cord-006860-a3b8hyyr	715	32	(	(	-LRB-
cord-006860-a3b8hyyr	715	33	free	free	JJ
cord-006860-a3b8hyyr	715	34	PS	PS	NNP
cord-006860-a3b8hyyr	715	35	0.30	0.30	CD
cord-006860-a3b8hyyr	715	36	U	U	NNP
cord-006860-a3b8hyyr	715	37	/	/	SYM
cord-006860-a3b8hyyr	715	38	I	I	NNP
cord-006860-a3b8hyyr	715	39	,	,	,
cord-006860-a3b8hyyr	715	40	total	total	JJ
cord-006860-a3b8hyyr	715	41	PS	PS	NNP
cord-006860-a3b8hyyr	715	42	0.58	0.58	CD
cord-006860-a3b8hyyr	715	43	U	U	NNP
cord-006860-a3b8hyyr	715	44	/	/	SYM
cord-006860-a3b8hyyr	715	45	I	i	NN
cord-006860-a3b8hyyr	715	46	)	)	-RRB-
cord-006860-a3b8hyyr	715	47	in	in	IN
cord-006860-a3b8hyyr	715	48	her	-PRON-	PRP$
cord-006860-a3b8hyyr	715	49	nsymptomatic	nsymptomatic	JJ
cord-006860-a3b8hyyr	715	50	mother	mother	NN
cord-006860-a3b8hyyr	715	51	and	and	CC
cord-006860-a3b8hyyr	715	52	no	no	DT
cord-006860-a3b8hyyr	715	53	defect	defect	NN
cord-006860-a3b8hyyr	715	54	in	in	IN
cord-006860-a3b8hyyr	715	55	her	-PRON-	PRP$
cord-006860-a3b8hyyr	715	56	sister	sister	NN
cord-006860-a3b8hyyr	715	57	.	.	.
cord-006860-a3b8hyyr	716	1	Considering	consider	VBG
cord-006860-a3b8hyyr	716	2	the	the	DT
cord-006860-a3b8hyyr	716	3	fact	fact	NN
cord-006860-a3b8hyyr	716	4	that	that	IN
cord-006860-a3b8hyyr	716	5	the	the	DT
cord-006860-a3b8hyyr	716	6	mother	mother	NN
cord-006860-a3b8hyyr	716	7	was	be	VBD
cord-006860-a3b8hyyr	716	8	still	still	RB
cord-006860-a3b8hyyr	716	9	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	716	10	free	free	JJ
cord-006860-a3b8hyyr	716	11	at	at	IN
cord-006860-a3b8hyyr	716	12	the	the	DT
cord-006860-a3b8hyyr	716	13	age	age	NN
cord-006860-a3b8hyyr	716	14	of	of	IN
cord-006860-a3b8hyyr	716	15	49	49	CD
cord-006860-a3b8hyyr	716	16	one	one	CD
cord-006860-a3b8hyyr	716	17	may	may	MD
cord-006860-a3b8hyyr	716	18	assume	assume	VB
cord-006860-a3b8hyyr	716	19	that	that	IN
cord-006860-a3b8hyyr	716	20	the	the	DT
cord-006860-a3b8hyyr	716	21	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	716	22	risk	risk	NN
cord-006860-a3b8hyyr	716	23	in	in	IN
cord-006860-a3b8hyyr	716	24	the	the	DT
cord-006860-a3b8hyyr	716	25	proposita	proposita	NN
cord-006860-a3b8hyyr	716	26	was	be	VBD
cord-006860-a3b8hyyr	716	27	mainly	mainly	RB
cord-006860-a3b8hyyr	716	28	influenced	influence	VBN
cord-006860-a3b8hyyr	716	29	by	by	IN
cord-006860-a3b8hyyr	716	30	the	the	DT
cord-006860-a3b8hyyr	716	31	homozygnsity	homozygnsity	NN
cord-006860-a3b8hyyr	716	32	for	for	IN
cord-006860-a3b8hyyr	716	33	APC	APC	NNP
cord-006860-a3b8hyyr	716	34	resistance	resistance	NN
cord-006860-a3b8hyyr	716	35	.	.	.
cord-006860-a3b8hyyr	717	1	S.	S.	NNP
cord-006860-a3b8hyyr	717	2	Ehrenforth	Ehrenforth	NNP
cord-006860-a3b8hyyr	717	3	,	,	,
cord-006860-a3b8hyyr	717	4	M.	M.	NNP
cord-006860-a3b8hyyr	717	5	Adam	Adam	NNP
cord-006860-a3b8hyyr	717	6	,	,	,
cord-006860-a3b8hyyr	717	7	B.	B.	NNP
cord-006860-a3b8hyyr	717	8	Zwinge	Zwinge	NNP
cord-006860-a3b8hyyr	717	9	,	,	,
cord-006860-a3b8hyyr	717	10	I.	I.	NNP
cord-006860-a3b8hyyr	717	11	Scharrer	Scharrer	NNP
cord-006860-a3b8hyyr	717	12	University	University	NNP
cord-006860-a3b8hyyr	717	13	Hospital	Hospital	NNP
cord-006860-a3b8hyyr	717	14	,	,	,
cord-006860-a3b8hyyr	717	15	Dept	Dept	NNP
cord-006860-a3b8hyyr	717	16	.	.	NNP
cord-006860-a3b8hyyr	717	17	of	of	IN
cord-006860-a3b8hyyr	717	18	Angiology	Angiology	NNP
cord-006860-a3b8hyyr	717	19	,	,	,
cord-006860-a3b8hyyr	718	1	Frankfurt	Frankfurt	NNP
cord-006860-a3b8hyyr	718	2	a	a	DT
cord-006860-a3b8hyyr	718	3	.	.	.
cord-006860-a3b8hyyr	718	4	M.	M.	NNP
cord-006860-a3b8hyyr	718	5	,	,	,
cord-006860-a3b8hyyr	718	6	Germany	Germany	NNP
cord-006860-a3b8hyyr	718	7	Introduction	introduction	NN
cord-006860-a3b8hyyr	718	8	:	:	:
cord-006860-a3b8hyyr	719	1	APC	APC	NNP
cord-006860-a3b8hyyr	719	2	resistance	resistance	NN
cord-006860-a3b8hyyr	719	3	has	have	VBZ
cord-006860-a3b8hyyr	719	4	been	be	VBN
cord-006860-a3b8hyyr	719	5	shown	show	VBN
cord-006860-a3b8hyyr	719	6	to	to	TO
cord-006860-a3b8hyyr	719	7	be	be	VB
cord-006860-a3b8hyyr	719	8	the	the	DT
cord-006860-a3b8hyyr	719	9	most	most	RBS
cord-006860-a3b8hyyr	719	10	commonly	commonly	RB
cord-006860-a3b8hyyr	719	11	inherited	inherit	VBN
cord-006860-a3b8hyyr	719	12	defect	defect	NN
cord-006860-a3b8hyyr	719	13	which	which	WDT
cord-006860-a3b8hyyr	719	14	constitutes	constitute	VBZ
cord-006860-a3b8hyyr	719	15	a	a	DT
cord-006860-a3b8hyyr	719	16	risk	risk	NN
cord-006860-a3b8hyyr	719	17	factor	factor	NN
cord-006860-a3b8hyyr	719	18	for	for	IN
cord-006860-a3b8hyyr	719	19	venous	venous	JJ
cord-006860-a3b8hyyr	719	20	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	719	21	(	(	-LRB-
cord-006860-a3b8hyyr	719	22	VT	VT	NNP
cord-006860-a3b8hyyr	719	23	)	)	-RRB-
cord-006860-a3b8hyyr	719	24	.	.	.
cord-006860-a3b8hyyr	720	1	However	however	RB
cord-006860-a3b8hyyr	720	2	,	,	,
cord-006860-a3b8hyyr	720	3	most	most	JJS
cord-006860-a3b8hyyr	720	4	of	of	IN
cord-006860-a3b8hyyr	720	5	the	the	DT
cord-006860-a3b8hyyr	720	6	present	present	JJ
cord-006860-a3b8hyyr	720	7	epidemiological	epidemiological	JJ
cord-006860-a3b8hyyr	720	8	studies	study	NNS
cord-006860-a3b8hyyr	720	9	concerning	concern	VBG
cord-006860-a3b8hyyr	720	10	APC	APC	NNP
cord-006860-a3b8hyyr	720	11	-	-	HYPH
cord-006860-a3b8hyyr	720	12	R	r	NN
cord-006860-a3b8hyyr	720	13	prevalence	prevalence	NN
cord-006860-a3b8hyyr	720	14	in	in	IN
cord-006860-a3b8hyyr	720	15	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	720	16	were	be	VBD
cord-006860-a3b8hyyr	720	17	derived	derive	VBN
cord-006860-a3b8hyyr	720	18	from	from	IN
cord-006860-a3b8hyyr	720	19	results	result	NNS
cord-006860-a3b8hyyr	720	20	of	of	IN
cord-006860-a3b8hyyr	720	21	tests	test	NNS
cord-006860-a3b8hyyr	720	22	conducted	conduct	VBN
cord-006860-a3b8hyyr	720	23	onplasmas	onplasmas	NNP
cord-006860-a3b8hyyr	720	24	collected	collect	VBN
cord-006860-a3b8hyyr	720	25	under	under	IN
cord-006860-a3b8hyyr	720	26	various	various	JJ
cord-006860-a3b8hyyr	720	27	conditions	condition	NNS
cord-006860-a3b8hyyr	720	28	.	.	.
cord-006860-a3b8hyyr	721	1	This	this	DT
cord-006860-a3b8hyyr	721	2	may	may	MD
cord-006860-a3b8hyyr	721	3	influence	influence	VB
cord-006860-a3b8hyyr	721	4	the	the	DT
cord-006860-a3b8hyyr	721	5	great	great	JJ
cord-006860-a3b8hyyr	721	6	differences	difference	NNS
cord-006860-a3b8hyyr	721	7	reported	report	VBN
cord-006860-a3b8hyyr	721	8	on	on	IN
cord-006860-a3b8hyyr	721	9	the	the	DT
cord-006860-a3b8hyyr	721	10	prevalence	prevalence	NN
cord-006860-a3b8hyyr	721	11	of	of	IN
cord-006860-a3b8hyyr	721	12	APC	APC	NNP
cord-006860-a3b8hyyr	721	13	-	-	HYPH
cord-006860-a3b8hyyr	721	14	R	R	NNP
cord-006860-a3b8hyyr	721	15	among	among	IN
cord-006860-a3b8hyyr	721	16	these	these	DT
cord-006860-a3b8hyyr	721	17	patients	patient	NNS
cord-006860-a3b8hyyr	721	18	.	.	.
cord-006860-a3b8hyyr	722	1	For	for	IN
cord-006860-a3b8hyyr	722	2	example	example	NN
cord-006860-a3b8hyyr	722	3	,	,	,
cord-006860-a3b8hyyr	722	4	it	-PRON-	PRP
cord-006860-a3b8hyyr	722	5	has	have	VBZ
cord-006860-a3b8hyyr	722	6	been	be	VBN
cord-006860-a3b8hyyr	722	7	shown	show	VBN
cord-006860-a3b8hyyr	722	8	that	that	IN
cord-006860-a3b8hyyr	722	9	freezing	freezing	NN
cord-006860-a3b8hyyr	722	10	of	of	IN
cord-006860-a3b8hyyr	722	11	plasma	plasma	NN
cord-006860-a3b8hyyr	722	12	specimens	specimen	NNS
cord-006860-a3b8hyyr	722	13	prior	prior	RB
cord-006860-a3b8hyyr	722	14	to	to	IN
cord-006860-a3b8hyyr	722	15	analysis	analysis	NN
cord-006860-a3b8hyyr	722	16	of	of	IN
cord-006860-a3b8hyyr	722	17	APC	APC	NNP
cord-006860-a3b8hyyr	722	18	-	-	HYPH
cord-006860-a3b8hyyr	722	19	R	R	NNP
cord-006860-a3b8hyyr	722	20	causes	cause	VBZ
cord-006860-a3b8hyyr	722	21	a	a	DT
cord-006860-a3b8hyyr	722	22	significant	significant	JJ
cord-006860-a3b8hyyr	722	23	decrease	decrease	NN
cord-006860-a3b8hyyr	722	24	in	in	IN
cord-006860-a3b8hyyr	722	25	the	the	DT
cord-006860-a3b8hyyr	722	26	assay	assay	NN
cord-006860-a3b8hyyr	722	27	results	result	NNS
cord-006860-a3b8hyyr	722	28	.	.	.
cord-006860-a3b8hyyr	723	1	The	the	DT
cord-006860-a3b8hyyr	723	2	aim	aim	NN
cord-006860-a3b8hyyr	723	3	of	of	IN
cord-006860-a3b8hyyr	723	4	our	-PRON-	PRP$
cord-006860-a3b8hyyr	723	5	study	study	NN
cord-006860-a3b8hyyr	723	6	was	be	VBD
cord-006860-a3b8hyyr	723	7	to	to	TO
cord-006860-a3b8hyyr	723	8	evaluate	evaluate	VB
cord-006860-a3b8hyyr	723	9	the	the	DT
cord-006860-a3b8hyyr	723	10	influence	influence	NN
cord-006860-a3b8hyyr	723	11	of	of	IN
cord-006860-a3b8hyyr	723	12	eentrifugation	eentrifugation	NN
cord-006860-a3b8hyyr	723	13	conditions	condition	NNS
cord-006860-a3b8hyyr	723	14	on	on	IN
cord-006860-a3b8hyyr	723	15	the	the	DT
cord-006860-a3b8hyyr	723	16	results	result	NNS
cord-006860-a3b8hyyr	723	17	obtained	obtain	VBN
cord-006860-a3b8hyyr	723	18	with	with	IN
cord-006860-a3b8hyyr	723	19	the	the	DT
cord-006860-a3b8hyyr	723	20	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	723	21	APC	APC	NNP
cord-006860-a3b8hyyr	723	22	-	-	HYPH
cord-006860-a3b8hyyr	723	23	R	r	NN
cord-006860-a3b8hyyr	723	24	assay	assay	NN
cord-006860-a3b8hyyr	723	25	.	.	.
cord-006860-a3b8hyyr	724	1	Patients	patient	NNS
cord-006860-a3b8hyyr	724	2	and	and	CC
cord-006860-a3b8hyyr	724	3	Methods	method	NNS
cord-006860-a3b8hyyr	724	4	:	:	:
cord-006860-a3b8hyyr	724	5	Blood	blood	NN
cord-006860-a3b8hyyr	724	6	was	be	VBD
cord-006860-a3b8hyyr	724	7	collected	collect	VBN
cord-006860-a3b8hyyr	724	8	from	from	IN
cord-006860-a3b8hyyr	724	9	31	31	CD
cord-006860-a3b8hyyr	724	10	patients	patient	NNS
cord-006860-a3b8hyyr	724	11	(	(	-LRB-
cord-006860-a3b8hyyr	724	12	t9	t9	NNP
cord-006860-a3b8hyyr	724	13	women	woman	NNS
cord-006860-a3b8hyyr	724	14	,	,	,
cord-006860-a3b8hyyr	724	15	12	12	CD
cord-006860-a3b8hyyr	724	16	men	man	NNS
cord-006860-a3b8hyyr	724	17	;	;	:
cord-006860-a3b8hyyr	724	18	FV	FV	NNP
cord-006860-a3b8hyyr	724	19	gent.type	gent.type	NN
cord-006860-a3b8hyyr	724	20	:	:	:
cord-006860-a3b8hyyr	724	21	13	13	CD
cord-006860-a3b8hyyr	724	22	R	r	NN
cord-006860-a3b8hyyr	724	23	/	/	SYM
cord-006860-a3b8hyyr	724	24	R	r	NN
cord-006860-a3b8hyyr	724	25	506	506	CD
cord-006860-a3b8hyyr	724	26	,	,	,
cord-006860-a3b8hyyr	724	27	14	14	CD
cord-006860-a3b8hyyr	724	28	R	r	NN
cord-006860-a3b8hyyr	724	29	/	/	SYM
cord-006860-a3b8hyyr	724	30	Q	Q	NNP
cord-006860-a3b8hyyr	724	31	506	506	CD
cord-006860-a3b8hyyr	724	32	,	,	,
cord-006860-a3b8hyyr	724	33	4	4	CD
cord-006860-a3b8hyyr	724	34	Q	q	NN
cord-006860-a3b8hyyr	724	35	/	/	SYM
cord-006860-a3b8hyyr	724	36	Q	Q	NNP
cord-006860-a3b8hyyr	724	37	506	506	CD
cord-006860-a3b8hyyr	724	38	)	)	-RRB-
cord-006860-a3b8hyyr	724	39	through	through	IN
cord-006860-a3b8hyyr	724	40	veinpuncture	veinpuncture	NN
cord-006860-a3b8hyyr	724	41	into	into	IN
cord-006860-a3b8hyyr	724	42	trisodmm	trisodmm	NNP
cord-006860-a3b8hyyr	724	43	ciwat	ciwat	NNP
cord-006860-a3b8hyyr	724	44	(	(	-LRB-
cord-006860-a3b8hyyr	724	45	1:9	1:9	CD
cord-006860-a3b8hyyr	724	46	)	)	-RRB-
cord-006860-a3b8hyyr	724	47	.	.	.
cord-006860-a3b8hyyr	725	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	725	2	-	-	HYPH
cord-006860-a3b8hyyr	725	3	rieh	rieh	NN
cord-006860-a3b8hyyr	725	4	and	and	CC
cord-006860-a3b8hyyr	725	5	platelet	platelet	NN
cord-006860-a3b8hyyr	725	6	-	-	HYPH
cord-006860-a3b8hyyr	725	7	poor	poor	JJ
cord-006860-a3b8hyyr	725	8	plasma	plasma	NN
cord-006860-a3b8hyyr	725	9	was	be	VBD
cord-006860-a3b8hyyr	725	10	obtained	obtain	VBN
cord-006860-a3b8hyyr	725	11	by	by	IN
cord-006860-a3b8hyyr	725	12	immediately	immediately	RB
cord-006860-a3b8hyyr	725	13	centrifugation	centrifugation	VBG
cord-006860-a3b8hyyr	725	14	at	at	IN
cord-006860-a3b8hyyr	725	15	4"C	4"c	CD
cord-006860-a3b8hyyr	725	16	for	for	IN
cord-006860-a3b8hyyr	725	17	10	10	CD
cord-006860-a3b8hyyr	725	18	,	,	,
cord-006860-a3b8hyyr	725	19	20	20	CD
cord-006860-a3b8hyyr	725	20	,	,	,
cord-006860-a3b8hyyr	725	21	30	30	CD
cord-006860-a3b8hyyr	725	22	,	,	,
cord-006860-a3b8hyyr	725	23	40	40	CD
cord-006860-a3b8hyyr	725	24	,	,	,
cord-006860-a3b8hyyr	725	25	50	50	CD
cord-006860-a3b8hyyr	725	26	,	,	,
cord-006860-a3b8hyyr	725	27	60	60	CD
cord-006860-a3b8hyyr	725	28	rain	rain	NN
cord-006860-a3b8hyyr	725	29	at	at	IN
cord-006860-a3b8hyyr	725	30	1000	1000	CD
cord-006860-a3b8hyyr	725	31	,	,	,
cord-006860-a3b8hyyr	725	32	2000	2000	CD
cord-006860-a3b8hyyr	725	33	,	,	,
cord-006860-a3b8hyyr	725	34	3000	3000	CD
cord-006860-a3b8hyyr	725	35	,	,	,
cord-006860-a3b8hyyr	725	36	4000	4000	CD
cord-006860-a3b8hyyr	725	37	,	,	,
cord-006860-a3b8hyyr	725	38	5000	5000	CD
cord-006860-a3b8hyyr	725	39	and	and	CC
cord-006860-a3b8hyyr	725	40	6000	6000	CD
cord-006860-a3b8hyyr	725	41	rpm	rpm	NN
cord-006860-a3b8hyyr	725	42	.	.	.
cord-006860-a3b8hyyr	726	1	Additional	additional	JJ
cord-006860-a3b8hyyr	726	2	,	,	,
cord-006860-a3b8hyyr	726	3	PNP	PNP	NNP
cord-006860-a3b8hyyr	726	4	obtained	obtain	VBD
cord-006860-a3b8hyyr	726	5	from	from	IN
cord-006860-a3b8hyyr	726	6	14	14	CD
cord-006860-a3b8hyyr	726	7	healthy	healthy	JJ
cord-006860-a3b8hyyr	726	8	individuals	individual	NNS
cord-006860-a3b8hyyr	726	9	(	(	-LRB-
cord-006860-a3b8hyyr	726	10	7	7	CD
cord-006860-a3b8hyyr	726	11	male	male	NN
cord-006860-a3b8hyyr	726	12	,	,	,
cord-006860-a3b8hyyr	726	13	7	7	CD
cord-006860-a3b8hyyr	726	14	female	female	NN
cord-006860-a3b8hyyr	726	15	without	without	IN
cord-006860-a3b8hyyr	726	16	hormonal	hormonal	JJ
cord-006860-a3b8hyyr	726	17	trealraent	trealraent	NN
cord-006860-a3b8hyyr	726	18	)	)	-RRB-
cord-006860-a3b8hyyr	726	19	was	be	VBD
cord-006860-a3b8hyyr	726	20	prepared	prepare	VBN
cord-006860-a3b8hyyr	726	21	equally	equally	RB
cord-006860-a3b8hyyr	726	22	.	.	.
cord-006860-a3b8hyyr	727	1	APC	APC	NNP
cord-006860-a3b8hyyr	727	2	-	-	HYPH
cord-006860-a3b8hyyr	727	3	response	response	NN
cord-006860-a3b8hyyr	727	4	was	be	VBD
cord-006860-a3b8hyyr	727	5	determined	determine	VBN
cord-006860-a3b8hyyr	727	6	within	within	IN
cord-006860-a3b8hyyr	727	7	one	one	CD
cord-006860-a3b8hyyr	727	8	hour	hour	NN
cord-006860-a3b8hyyr	727	9	after	after	IN
cord-006860-a3b8hyyr	727	10	centrifugation	centrifugation	NN
cord-006860-a3b8hyyr	727	11	using	use	VBG
cord-006860-a3b8hyyr	727	12	the	the	DT
cord-006860-a3b8hyyr	727	13	Coatest	Coatest	NNP
cord-006860-a3b8hyyr	727	14	APC	APC	NNP
cord-006860-a3b8hyyr	727	15	resistance	resistance	NN
cord-006860-a3b8hyyr	727	16	kit	kit	NN
cord-006860-a3b8hyyr	727	17	from	from	IN
cord-006860-a3b8hyyr	727	18	Chromogenix	Chromogenix	NNP
cord-006860-a3b8hyyr	727	19	.	.	.
cord-006860-a3b8hyyr	728	1	Results	result	NNS
cord-006860-a3b8hyyr	728	2	:	:	:
cord-006860-a3b8hyyr	729	1	For	for	IN
cord-006860-a3b8hyyr	729	2	both	both	DT
cord-006860-a3b8hyyr	729	3	,	,	,
cord-006860-a3b8hyyr	729	4	PNP	PNP	NNP
cord-006860-a3b8hyyr	729	5	and	and	CC
cord-006860-a3b8hyyr	729	6	sin	sin	NN
cord-006860-a3b8hyyr	729	7	/	/	SYM
cord-006860-a3b8hyyr	729	8	gle	gle	NNP
cord-006860-a3b8hyyr	729	9	plasma	plasma	NN
cord-006860-a3b8hyyr	729	10	samples	sample	NNS
cord-006860-a3b8hyyr	729	11	,	,	,
cord-006860-a3b8hyyr	729	12	we	-PRON-	PRP
cord-006860-a3b8hyyr	729	13	observed	observe	VBD
cord-006860-a3b8hyyr	729	14	continuous	continuous	JJ
cord-006860-a3b8hyyr	729	15	higher	high	JJR
cord-006860-a3b8hyyr	729	16	AF'C	AF'C	NNS
cord-006860-a3b8hyyr	729	17	-	-	HYPH
cord-006860-a3b8hyyr	729	18	ratios	ratio	NNS
cord-006860-a3b8hyyr	729	19	after	after	IN
cord-006860-a3b8hyyr	729	20	increasing	increase	VBG
cord-006860-a3b8hyyr	729	21	cenWifugation	cenwifugation	NN
cord-006860-a3b8hyyr	729	22	intensity	intensity	NN
cord-006860-a3b8hyyr	729	23	.	.	.
cord-006860-a3b8hyyr	730	1	For	for	IN
cord-006860-a3b8hyyr	730	2	example	example	NN
cord-006860-a3b8hyyr	730	3	,	,	,
cord-006860-a3b8hyyr	730	4	an	an	DT
cord-006860-a3b8hyyr	730	5	increase	increase	NN
cord-006860-a3b8hyyr	730	6	from	from	IN
cord-006860-a3b8hyyr	730	7	1000	1000	CD
cord-006860-a3b8hyyr	730	8	to	to	IN
cord-006860-a3b8hyyr	730	9	6000	6000	CD
cord-006860-a3b8hyyr	730	10	rpm	rpm	NN
cord-006860-a3b8hyyr	730	11	resulted	result	VBD
cord-006860-a3b8hyyr	730	12	m	m	NNP
cord-006860-a3b8hyyr	730	13	an	an	DT
cord-006860-a3b8hyyr	730	14	increased	increase	VBN
cord-006860-a3b8hyyr	730	15	APCratio	apcratio	NN
cord-006860-a3b8hyyr	730	16	from	from	IN
cord-006860-a3b8hyyr	730	17	2.7	2.7	CD
cord-006860-a3b8hyyr	730	18	to	to	IN
cord-006860-a3b8hyyr	730	19	3.26	3.26	CD
cord-006860-a3b8hyyr	730	20	(	(	-LRB-
cord-006860-a3b8hyyr	730	21	20	20	CD
cord-006860-a3b8hyyr	730	22	min	min	NN
cord-006860-a3b8hyyr	730	23	)	)	-RRB-
cord-006860-a3b8hyyr	730	24	,	,	,
cord-006860-a3b8hyyr	730	25	from	from	IN
cord-006860-a3b8hyyr	730	26	2.88	2.88	CD
cord-006860-a3b8hyyr	730	27	to	to	IN
cord-006860-a3b8hyyr	730	28	3.326	3.326	CD
cord-006860-a3b8hyyr	730	29	(	(	-LRB-
cord-006860-a3b8hyyr	730	30	60	60	CD
cord-006860-a3b8hyyr	730	31	rain	rain	NN
cord-006860-a3b8hyyr	730	32	)	)	-RRB-
cord-006860-a3b8hyyr	730	33	respectively	respectively	RB
cord-006860-a3b8hyyr	730	34	.	.	.
cord-006860-a3b8hyyr	731	1	Even	even	RB
cord-006860-a3b8hyyr	731	2	though	though	IN
cord-006860-a3b8hyyr	731	3	less	less	RBR
cord-006860-a3b8hyyr	731	4	distinctive	distinctive	JJ
cord-006860-a3b8hyyr	731	5	,	,	,
cord-006860-a3b8hyyr	731	6	similar	similar	JJ
cord-006860-a3b8hyyr	731	7	results	result	NNS
cord-006860-a3b8hyyr	731	8	were	be	VBD
cord-006860-a3b8hyyr	731	9	observed	observe	VBN
cord-006860-a3b8hyyr	731	10	concerning	concern	VBG
cord-006860-a3b8hyyr	731	11	the	the	DT
cord-006860-a3b8hyyr	731	12	duration	duration	NN
cord-006860-a3b8hyyr	731	13	ol	old	IN
cord-006860-a3b8hyyr	731	14	eentrifugation	eentrifugation	NN
cord-006860-a3b8hyyr	731	15	:	:	:
cord-006860-a3b8hyyr	731	16	when	when	WRB
cord-006860-a3b8hyyr	731	17	the	the	DT
cord-006860-a3b8hyyr	731	18	duration	duration	NN
cord-006860-a3b8hyyr	731	19	was	be	VBD
cord-006860-a3b8hyyr	731	20	increased	increase	VBN
cord-006860-a3b8hyyr	731	21	from	from	IN
cord-006860-a3b8hyyr	731	22	10	10	CD
cord-006860-a3b8hyyr	731	23	to	to	TO
cord-006860-a3b8hyyr	731	24	60	60	CD
cord-006860-a3b8hyyr	731	25	minutes	minute	NNS
cord-006860-a3b8hyyr	731	26	we	-PRON-	PRP
cord-006860-a3b8hyyr	731	27	observed	observe	VBD
cord-006860-a3b8hyyr	731	28	a	a	DT
cord-006860-a3b8hyyr	731	29	continuous	continuous	JJ
cord-006860-a3b8hyyr	731	30	increase	increase	NN
cord-006860-a3b8hyyr	731	31	in	in	IN
cord-006860-a3b8hyyr	731	32	APC	APC	NNP
cord-006860-a3b8hyyr	731	33	-	-	HYPH
cord-006860-a3b8hyyr	731	34	ratio	ratio	NN
cord-006860-a3b8hyyr	731	35	,	,	,
cord-006860-a3b8hyyr	731	36	for	for	IN
cord-006860-a3b8hyyr	731	37	example	example	NN
cord-006860-a3b8hyyr	731	38	from	from	IN
cord-006860-a3b8hyyr	731	39	2.74	2.74	CD
cord-006860-a3b8hyyr	731	40	to	to	IN
cord-006860-a3b8hyyr	731	41	3.12	3.12	CD
cord-006860-a3b8hyyr	731	42	when	when	WRB
cord-006860-a3b8hyyr	731	43	using	use	VBG
cord-006860-a3b8hyyr	731	44	2000	2000	CD
cord-006860-a3b8hyyr	731	45	rpm	rpm	NN
cord-006860-a3b8hyyr	731	46	and	and	CC
cord-006860-a3b8hyyr	731	47	from	from	IN
cord-006860-a3b8hyyr	731	48	3.09	3.09	CD
cord-006860-a3b8hyyr	731	49	to	to	IN
cord-006860-a3b8hyyr	731	50	3.36	3.36	CD
cord-006860-a3b8hyyr	731	51	when	when	WRB
cord-006860-a3b8hyyr	731	52	using	use	VBG
cord-006860-a3b8hyyr	731	53	4000	4000	CD
cord-006860-a3b8hyyr	731	54	rpm	rpm	NN
cord-006860-a3b8hyyr	731	55	.	.	.
cord-006860-a3b8hyyr	732	1	The	the	DT
cord-006860-a3b8hyyr	732	2	decrease	decrease	NN
cord-006860-a3b8hyyr	732	3	of	of	IN
cord-006860-a3b8hyyr	732	4	the	the	DT
cord-006860-a3b8hyyr	732	5	ratio	ratio	NN
cord-006860-a3b8hyyr	732	6	after	after	IN
cord-006860-a3b8hyyr	732	7	low	low	JJ
cord-006860-a3b8hyyr	732	8	eentrifugation	eentrifugation	NN
cord-006860-a3b8hyyr	732	9	is	be	VBZ
cord-006860-a3b8hyyr	732	10	the	the	DT
cord-006860-a3b8hyyr	732	11	eonse-9nence	eonse-9nence	NN
cord-006860-a3b8hyyr	732	12	of	of	IN
cord-006860-a3b8hyyr	732	13	the	the	DT
cord-006860-a3b8hyyr	732	14	shortening	shortening	NN
cord-006860-a3b8hyyr	732	15	of	of	IN
cord-006860-a3b8hyyr	732	16	AFffT	AFffT	NNP
cord-006860-a3b8hyyr	732	17	in	in	IN
cord-006860-a3b8hyyr	732	18	the	the	DT
cord-006860-a3b8hyyr	732	19	presence	presence	NN
cord-006860-a3b8hyyr	732	20	of	of	IN
cord-006860-a3b8hyyr	732	21	APC	APC	NNP
cord-006860-a3b8hyyr	732	22	,	,	,
cord-006860-a3b8hyyr	732	23	without	without	IN
cord-006860-a3b8hyyr	732	24	a	a	DT
cord-006860-a3b8hyyr	732	25	signhcant	signhcant	JJ
cord-006860-a3b8hyyr	732	26	influence	influence	NN
cord-006860-a3b8hyyr	732	27	of	of	IN
cord-006860-a3b8hyyr	732	28	basal	basal	NN
cord-006860-a3b8hyyr	732	29	Al	Al	NNP
cord-006860-a3b8hyyr	732	30	:	:	:
cord-006860-a3b8hyyr	732	31	rl~	rl~	NNP
cord-006860-a3b8hyyr	732	32	without	without	IN
cord-006860-a3b8hyyr	732	33	APC	APC	NNP
cord-006860-a3b8hyyr	732	34	.	.	.
cord-006860-a3b8hyyr	733	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	733	2	:	:	:
cord-006860-a3b8hyyr	734	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	734	2	results	result	NNS
cord-006860-a3b8hyyr	734	3	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	734	4	that	that	IN
cord-006860-a3b8hyyr	734	5	centrifugation	centrifugation	NN
cord-006860-a3b8hyyr	734	6	conditions	condition	NNS
cord-006860-a3b8hyyr	734	7	are	be	VBP
cord-006860-a3b8hyyr	734	8	important	important	JJ
cord-006860-a3b8hyyr	734	9	to	to	TO
cord-006860-a3b8hyyr	734	10	consider	consider	VB
cord-006860-a3b8hyyr	734	11	for	for	IN
cord-006860-a3b8hyyr	734	12	the	the	DT
cord-006860-a3b8hyyr	734	13	interpretation	interpretation	NN
cord-006860-a3b8hyyr	734	14	of	of	IN
cord-006860-a3b8hyyr	734	15	APC	APC	NNP
cord-006860-a3b8hyyr	734	16	-	-	HYPH
cord-006860-a3b8hyyr	734	17	R	R	NNP
cord-006860-a3b8hyyr	734	18	results	result	NNS
cord-006860-a3b8hyyr	734	19	.	.	.
cord-006860-a3b8hyyr	735	1	Supporting	support	VBG
cord-006860-a3b8hyyr	735	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	735	3	observations	observation	NNS
cord-006860-a3b8hyyr	735	4	,	,	,
cord-006860-a3b8hyyr	735	5	recent	recent	JJ
cord-006860-a3b8hyyr	735	6	studies	study	NNS
cord-006860-a3b8hyyr	735	7	from	from	IN
cord-006860-a3b8hyyr	735	8	Sidelmann	Sidelmann	NNP
cord-006860-a3b8hyyr	735	9	et	et	NNP
cord-006860-a3b8hyyr	735	10	al	al	NNP
cord-006860-a3b8hyyr	735	11	.	.	NNP
cord-006860-a3b8hyyr	735	12	have	have	VBP
cord-006860-a3b8hyyr	735	13	shown	show	VBN
cord-006860-a3b8hyyr	735	14	that	that	IN
cord-006860-a3b8hyyr	735	15	an	an	DT
cord-006860-a3b8hyyr	735	16	increase	increase	NN
cord-006860-a3b8hyyr	735	17	in	in	IN
cord-006860-a3b8hyyr	735	18	plasma	plasma	NN
cord-006860-a3b8hyyr	735	19	platelet	platelet	NN
cord-006860-a3b8hyyr	735	20	concentration	concentration	NN
cord-006860-a3b8hyyr	735	21	,	,	,
cord-006860-a3b8hyyr	735	22	low	low	JJ
cord-006860-a3b8hyyr	735	23	eentrifugation	eentrifugation	NN
cord-006860-a3b8hyyr	735	24	respectively	respectively	RB
cord-006860-a3b8hyyr	735	25	,	,	,
cord-006860-a3b8hyyr	735	26	causes	cause	VBZ
cord-006860-a3b8hyyr	735	27	a	a	DT
cord-006860-a3b8hyyr	735	28	signficant	signficant	JJ
cord-006860-a3b8hyyr	735	29	decrease	decrease	NN
cord-006860-a3b8hyyr	735	30	in	in	IN
cord-006860-a3b8hyyr	735	31	the	the	DT
cord-006860-a3b8hyyr	735	32	APC	APC	NNP
cord-006860-a3b8hyyr	735	33	-	-	HYPH
cord-006860-a3b8hyyr	735	34	response	response	NN
cord-006860-a3b8hyyr	735	35	.	.	.
cord-006860-a3b8hyyr	736	1	However	however	RB
cord-006860-a3b8hyyr	736	2	,	,	,
cord-006860-a3b8hyyr	736	3	so	so	RB
cord-006860-a3b8hyyr	736	4	far	far	RB
cord-006860-a3b8hyyr	736	5	the	the	DT
cord-006860-a3b8hyyr	736	6	mechanism	mechanism	NN
cord-006860-a3b8hyyr	736	7	responsible	responsible	JJ
cord-006860-a3b8hyyr	736	8	for	for	IN
cord-006860-a3b8hyyr	736	9	the	the	DT
cord-006860-a3b8hyyr	736	10	significant	significant	JJ
cord-006860-a3b8hyyr	736	11	effect	effect	NN
cord-006860-a3b8hyyr	736	12	of	of	IN
cord-006860-a3b8hyyr	736	13	both	both	DT
cord-006860-a3b8hyyr	736	14	on	on	IN
cord-006860-a3b8hyyr	736	15	APC	APC	NNP
cord-006860-a3b8hyyr	736	16	-	-	HYPH
cord-006860-a3b8hyyr	736	17	R	r	NN
cord-006860-a3b8hyyr	736	18	assay	assay	NN
cord-006860-a3b8hyyr	736	19	results	result	NNS
cord-006860-a3b8hyyr	736	20	is	be	VBZ
cord-006860-a3b8hyyr	736	21	unknown	unknown	JJ
cord-006860-a3b8hyyr	736	22	.	.	.
cord-006860-a3b8hyyr	737	1	Although	although	IN
cord-006860-a3b8hyyr	737	2	technically	technically	RB
cord-006860-a3b8hyyr	737	3	simple	simple	JJ
cord-006860-a3b8hyyr	737	4	,	,	,
cord-006860-a3b8hyyr	737	5	the	the	DT
cord-006860-a3b8hyyr	737	6	biochemical	biochemical	JJ
cord-006860-a3b8hyyr	737	7	cemplexitiy	cemplexitiy	NNS
cord-006860-a3b8hyyr	737	8	inherent	inherent	JJ
cord-006860-a3b8hyyr	737	9	in	in	IN
cord-006860-a3b8hyyr	737	10	the	the	DT
cord-006860-a3b8hyyr	737	11	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	737	12	APC	APC	NNP
cord-006860-a3b8hyyr	737	13	-	-	HYPH
cord-006860-a3b8hyyr	737	14	R	r	NN
cord-006860-a3b8hyyr	737	15	assay	assay	NN
cord-006860-a3b8hyyr	737	16	necessitates	necessitate	VBZ
cord-006860-a3b8hyyr	737	17	a	a	DT
cord-006860-a3b8hyyr	737	18	standardized	standardized	JJ
cord-006860-a3b8hyyr	737	19	plasma	plasma	NN
cord-006860-a3b8hyyr	737	20	handling	handling	NN
cord-006860-a3b8hyyr	737	21	procedure	procedure	NN
cord-006860-a3b8hyyr	737	22	to	to	TO
cord-006860-a3b8hyyr	737	23	secure	secure	VB
cord-006860-a3b8hyyr	737	24	a	a	DT
cord-006860-a3b8hyyr	737	25	reproducible	reproducible	JJ
cord-006860-a3b8hyyr	737	26	determination	determination	NN
cord-006860-a3b8hyyr	737	27	of	of	IN
cord-006860-a3b8hyyr	737	28	APC	APC	NNP
cord-006860-a3b8hyyr	737	29	-	-	HYPH
cord-006860-a3b8hyyr	737	30	IL	IL	NNP
cord-006860-a3b8hyyr	737	31	COMPAPJSON	compapjson	NN
cord-006860-a3b8hyyr	737	32	OF	of	IN
cord-006860-a3b8hyyr	737	33	DIFFERENT	different	JJ
cord-006860-a3b8hyyr	737	34	ASSAYS	assay	NNS
cord-006860-a3b8hyyr	737	35	FOR	for	IN
cord-006860-a3b8hyyr	737	36	DETERMINATION	determination	NN
cord-006860-a3b8hyyr	737	37	OF	of	IN
cord-006860-a3b8hyyr	737	38	APC	APC	NNP
cord-006860-a3b8hyyr	737	39	-	-	HYPH
cord-006860-a3b8hyyr	737	40	RESISTANCE	RESISTANCE	NNP
cord-006860-a3b8hyyr	737	41	WITH	with	IN
cord-006860-a3b8hyyr	737	42	THE	the	DT
cord-006860-a3b8hyyr	737	43	GENO'FYPING	geno'fyping	NN
cord-006860-a3b8hyyr	737	44	FACTOR	factor	NN
cord-006860-a3b8hyyr	737	45	V	v	NN
cord-006860-a3b8hyyr	738	1	(	(	-LRB-
cord-006860-a3b8hyyr	738	2	ARG	arg	NN
cord-006860-a3b8hyyr	738	3	-	-	HYPH
cord-006860-a3b8hyyr	738	4	>	>	XX
cord-006860-a3b8hyyr	738	5	GLU	glu	NN
cord-006860-a3b8hyyr	738	6	)	)	-RRB-
cord-006860-a3b8hyyr	739	1	G.	G.	NNP
cord-006860-a3b8hyyr	739	2	Siegert	Siegert	NNP
cord-006860-a3b8hyyr	739	3	*	*	NFP
cord-006860-a3b8hyyr	739	4	,	,	,
cord-006860-a3b8hyyr	739	5	S.	S.	NNP
cord-006860-a3b8hyyr	739	6	Gehrisch	Gehrisch	NNP
cord-006860-a3b8hyyr	739	7	*	*	NFP
cord-006860-a3b8hyyr	739	8	,	,	,
cord-006860-a3b8hyyr	739	9	E.	E.	NNP
cord-006860-a3b8hyyr	739	10	Runge	Runge	NNP
cord-006860-a3b8hyyr	740	1	*	*	NFP
cord-006860-a3b8hyyr	740	2	*	*	NFP
cord-006860-a3b8hyyr	740	3	.	.	.
cord-006860-a3b8hyyr	741	1	R.	R.	NNP
cord-006860-a3b8hyyr	741	2	Naumann	Naumann	NNP
cord-006860-a3b8hyyr	742	1	*	*	NFP
cord-006860-a3b8hyyr	742	2	*	*	NFP
cord-006860-a3b8hyyr	742	3	,	,	,
cord-006860-a3b8hyyr	742	4	R.	R.	NNP
cord-006860-a3b8hyyr	742	5	Kn6fler	kn6fler	NN
cord-006860-a3b8hyyr	743	1	*	*	NFP
cord-006860-a3b8hyyr	743	2	*	*	NFP
cord-006860-a3b8hyyr	743	3	*	*	NFP
cord-006860-a3b8hyyr	743	4	*	*	NFP
cord-006860-a3b8hyyr	743	5	Institute	Institute	NNP
cord-006860-a3b8hyyr	743	6	of	of	IN
cord-006860-a3b8hyyr	743	7	Clinical	Clinical	NNP
cord-006860-a3b8hyyr	743	8	Chemistry	Chemistry	NNP
cord-006860-a3b8hyyr	743	9	,	,	,
cord-006860-a3b8hyyr	744	1	*	*	NFP
cord-006860-a3b8hyyr	744	2	*	*	NFP
cord-006860-a3b8hyyr	744	3	Clinic	Clinic	NNP
cord-006860-a3b8hyyr	744	4	of	of	IN
cord-006860-a3b8hyyr	744	5	Internal	Internal	NNP
cord-006860-a3b8hyyr	744	6	Medicine	Medicine	NNP
cord-006860-a3b8hyyr	744	7	,	,	,
cord-006860-a3b8hyyr	745	1	*	*	NFP
cord-006860-a3b8hyyr	745	2	*	*	NFP
cord-006860-a3b8hyyr	745	3	*	*	NFP
cord-006860-a3b8hyyr	745	4	Childrens	Childrens	NNP
cord-006860-a3b8hyyr	745	5	Hospital	Hospital	NNP
cord-006860-a3b8hyyr	745	6	Resistance	Resistance	NNP
cord-006860-a3b8hyyr	745	7	to	to	IN
cord-006860-a3b8hyyr	745	8	APC	APC	NNP
cord-006860-a3b8hyyr	745	9	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	745	10	on	on	IN
cord-006860-a3b8hyyr	745	11	the	the	DT
cord-006860-a3b8hyyr	745	12	basis	basis	NN
cord-006860-a3b8hyyr	745	13	of	of	IN
cord-006860-a3b8hyyr	745	14	prolongated	prolongated	JJ
cord-006860-a3b8hyyr	745	15	clotting	clotting	NN
cord-006860-a3b8hyyr	745	16	time	time	NN
cord-006860-a3b8hyyr	745	17	in	in	IN
cord-006860-a3b8hyyr	745	18	the	the	DT
cord-006860-a3b8hyyr	745	19	aPTT	aptt	JJ
cord-006860-a3b8hyyr	745	20	assay	assay	NN
cord-006860-a3b8hyyr	745	21	"	"	''
cord-006860-a3b8hyyr	745	22	is	be	VBZ
cord-006860-a3b8hyyr	745	23	now	now	RB
cord-006860-a3b8hyyr	745	24	considered	consider	VBN
cord-006860-a3b8hyyr	745	25	a	a	DT
cord-006860-a3b8hyyr	745	26	major	major	JJ
cord-006860-a3b8hyyr	745	27	cause	cause	NN
cord-006860-a3b8hyyr	745	28	of	of	IN
cord-006860-a3b8hyyr	745	29	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	745	30	.	.	.
cord-006860-a3b8hyyr	746	1	In	in	IN
cord-006860-a3b8hyyr	746	2	the	the	DT
cord-006860-a3b8hyyr	746	3	majority	majority	NN
cord-006860-a3b8hyyr	746	4	APC	APC	NNP
cord-006860-a3b8hyyr	746	5	resistance	resistance	NN
cord-006860-a3b8hyyr	746	6	is	be	VBZ
cord-006860-a3b8hyyr	746	7	~ted	~te	VBN
cord-006860-a3b8hyyr	746	8	with	with	IN
cord-006860-a3b8hyyr	746	9	a	a	DT
cord-006860-a3b8hyyr	746	10	point	point	NN
cord-006860-a3b8hyyr	746	11	mutation	mutation	NN
cord-006860-a3b8hyyr	746	12	in	in	IN
cord-006860-a3b8hyyr	746	13	factor	factor	NN
cord-006860-a3b8hyyr	746	14	V	v	NN
cord-006860-a3b8hyyr	746	15	molecule	molecule	NN
cord-006860-a3b8hyyr	746	16	(	(	-LRB-
cord-006860-a3b8hyyr	746	17	Arg506Glu	Arg506Glu	NNP
cord-006860-a3b8hyyr	746	18	)	)	-RRB-
cord-006860-a3b8hyyr	746	19	,	,	,
cord-006860-a3b8hyyr	746	20	but	but	CC
cord-006860-a3b8hyyr	746	21	both	both	DT
cord-006860-a3b8hyyr	746	22	are	be	VBP
cord-006860-a3b8hyyr	746	23	not	not	RB
cord-006860-a3b8hyyr	746	24	synonym	synonym	JJ
cord-006860-a3b8hyyr	746	25	.	.	.
cord-006860-a3b8hyyr	747	1	Protongated	Protongated	NNP
cord-006860-a3b8hyyr	747	2	baseline	baseline	NN
cord-006860-a3b8hyyr	747	3	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	747	4	is	be	VBZ
cord-006860-a3b8hyyr	747	5	a	a	DT
cord-006860-a3b8hyyr	747	6	limitation	limitation	NN
cord-006860-a3b8hyyr	747	7	of	of	IN
cord-006860-a3b8hyyr	747	8	the	the	DT
cord-006860-a3b8hyyr	747	9	assay	assay	NN
cord-006860-a3b8hyyr	747	10	.	.	.
cord-006860-a3b8hyyr	748	1	Following	follow	VBG
cord-006860-a3b8hyyr	748	2	the	the	DT
cord-006860-a3b8hyyr	748	3	determination	determination	NN
cord-006860-a3b8hyyr	748	4	is	be	VBZ
cord-006860-a3b8hyyr	748	5	not	not	RB
cord-006860-a3b8hyyr	748	6	possible	possible	JJ
cord-006860-a3b8hyyr	748	7	in	in	IN
cord-006860-a3b8hyyr	748	8	risk	risk	NN
cord-006860-a3b8hyyr	748	9	groups	group	NNS
cord-006860-a3b8hyyr	748	10	of	of	IN
cord-006860-a3b8hyyr	748	11	patients	patient	NNS
cord-006860-a3b8hyyr	748	12	(	(	-LRB-
cord-006860-a3b8hyyr	748	13	factor)ill	factor)ill	JJ
cord-006860-a3b8hyyr	748	14	deficiency	deficiency	NN
cord-006860-a3b8hyyr	748	15	,	,	,
cord-006860-a3b8hyyr	748	16	Lupus	Lupus	NNP
cord-006860-a3b8hyyr	748	17	Anticoagulan0	Anticoagulan0	NNP
cord-006860-a3b8hyyr	748	18	and	and	CC
cord-006860-a3b8hyyr	748	19	in	in	IN
cord-006860-a3b8hyyr	748	20	patients	patient	NNS
cord-006860-a3b8hyyr	748	21	under	under	IN
cord-006860-a3b8hyyr	748	22	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	748	23	therapy	therapy	NN
cord-006860-a3b8hyyr	748	24	.	.	.
cord-006860-a3b8hyyr	749	1	In	in	IN
cord-006860-a3b8hyyr	749	2	these	these	DT
cord-006860-a3b8hyyr	749	3	causes	cause	VBZ
cord-006860-a3b8hyyr	749	4	a	a	DT
cord-006860-a3b8hyyr	749	5	dilution	dilution	NN
cord-006860-a3b8hyyr	749	6	of	of	IN
cord-006860-a3b8hyyr	749	7	plasma	plasma	NN
cord-006860-a3b8hyyr	749	8	in	in	IN
cord-006860-a3b8hyyr	749	9	factor	factor	NN
cord-006860-a3b8hyyr	749	10	V	v	NN
cord-006860-a3b8hyyr	749	11	deficient	deficient	JJ
cord-006860-a3b8hyyr	749	12	plasma	plasma	NN
cord-006860-a3b8hyyr	749	13	is	be	VBZ
cord-006860-a3b8hyyr	749	14	recommended	recommend	VBN
cord-006860-a3b8hyyr	749	15	.	.	.
cord-006860-a3b8hyyr	750	1	The	the	DT
cord-006860-a3b8hyyr	750	2	Immunochrom	Immunochrom	NNP
cord-006860-a3b8hyyr	750	3	assay	assay	NN
cord-006860-a3b8hyyr	750	4	is	be	VBZ
cord-006860-a3b8hyyr	750	5	based	base	VBN
cord-006860-a3b8hyyr	750	6	on	on	IN
cord-006860-a3b8hyyr	750	7	the	the	DT
cord-006860-a3b8hyyr	750	8	inactivation	inactivation	NN
cord-006860-a3b8hyyr	750	9	of	of	IN
cord-006860-a3b8hyyr	750	10	factor	factor	NN
cord-006860-a3b8hyyr	750	11	Villa	Villa	NNP
cord-006860-a3b8hyyr	750	12	by	by	IN
cord-006860-a3b8hyyr	750	13	APC	APC	NNP
cord-006860-a3b8hyyr	750	14	.	.	.
cord-006860-a3b8hyyr	751	1	The	the	DT
cord-006860-a3b8hyyr	751	2	aim	aim	NN
cord-006860-a3b8hyyr	751	3	of	of	IN
cord-006860-a3b8hyyr	751	4	the	the	DT
cord-006860-a3b8hyyr	751	5	study	study	NN
cord-006860-a3b8hyyr	751	6	was	be	VBD
cord-006860-a3b8hyyr	751	7	to	to	TO
cord-006860-a3b8hyyr	751	8	compare	compare	VB
cord-006860-a3b8hyyr	751	9	different	different	JJ
cord-006860-a3b8hyyr	751	10	functional	functional	JJ
cord-006860-a3b8hyyr	751	11	APC	APC	NNP
cord-006860-a3b8hyyr	751	12	response	response	NN
cord-006860-a3b8hyyr	751	13	assays	assay	NNS
cord-006860-a3b8hyyr	751	14	with	with	IN
cord-006860-a3b8hyyr	751	15	the	the	DT
cord-006860-a3b8hyyr	751	16	result	result	NN
cord-006860-a3b8hyyr	751	17	of	of	IN
cord-006860-a3b8hyyr	751	18	the	the	DT
cord-006860-a3b8hyyr	751	19	DNA	dna	NN
cord-006860-a3b8hyyr	751	20	analysis	analysis	NN
cord-006860-a3b8hyyr	751	21	.	.	.
cord-006860-a3b8hyyr	752	1	APC	APC	NNP
cord-006860-a3b8hyyr	752	2	response	response	NN
cord-006860-a3b8hyyr	752	3	was	be	VBD
cord-006860-a3b8hyyr	752	4	tested	test	VBN
cord-006860-a3b8hyyr	752	5	in	in	IN
cord-006860-a3b8hyyr	752	6	100	100	CD
cord-006860-a3b8hyyr	752	7	healthy	healthy	JJ
cord-006860-a3b8hyyr	752	8	probands	proband	NNS
cord-006860-a3b8hyyr	752	9	,	,	,
cord-006860-a3b8hyyr	753	1	81	81	CD
cord-006860-a3b8hyyr	753	2	thro~	thro~	NN
cord-006860-a3b8hyyr	753	3	patients	patient	NNS
cord-006860-a3b8hyyr	753	4	and	and	CC
cord-006860-a3b8hyyr	753	5	16	16	CD
cord-006860-a3b8hyyr	753	6	family	family	NN
cord-006860-a3b8hyyr	753	7	members	member	NNS
cord-006860-a3b8hyyr	753	8	using	use	VBG
cord-006860-a3b8hyyr	753	9	the	the	DT
cord-006860-a3b8hyyr	753	10	lmmtmochrem	lmmtmochrem	NNP
cord-006860-a3b8hyyr	753	11	assay	assay	NN
cord-006860-a3b8hyyr	753	12	,	,	,
cord-006860-a3b8hyyr	753	13	the	the	DT
cord-006860-a3b8hyyr	753	14	Contest	contest	NN
cord-006860-a3b8hyyr	753	15	(	(	-LRB-
cord-006860-a3b8hyyr	753	16	Chromogeaix	Chromogeaix	NNP
cord-006860-a3b8hyyr	753	17	)	)	-RRB-
cord-006860-a3b8hyyr	753	18	and	and	CC
cord-006860-a3b8hyyr	753	19	the	the	DT
cord-006860-a3b8hyyr	753	20	Contest	Contest	NNP
cord-006860-a3b8hyyr	753	21	with	with	IN
cord-006860-a3b8hyyr	753	22	1	1	CD
cord-006860-a3b8hyyr	753	23	+	+	SYM
cord-006860-a3b8hyyr	753	24	4	4	CD
cord-006860-a3b8hyyr	753	25	dilution	dilution	NN
cord-006860-a3b8hyyr	753	26	of	of	IN
cord-006860-a3b8hyyr	753	27	the	the	DT
cord-006860-a3b8hyyr	753	28	plasma	plasma	NN
cord-006860-a3b8hyyr	753	29	in	in	IN
cord-006860-a3b8hyyr	753	30	native	native	JJ
cord-006860-a3b8hyyr	753	31	factor	factor	NN
cord-006860-a3b8hyyr	754	1	V	v	LS
cord-006860-a3b8hyyr	754	2	deficient	deficient	JJ
cord-006860-a3b8hyyr	754	3	plasma	plasma	NN
cord-006860-a3b8hyyr	754	4	(	(	-LRB-
cord-006860-a3b8hyyr	754	5	Immune	immune	NN
cord-006860-a3b8hyyr	754	6	)	)	-RRB-
cord-006860-a3b8hyyr	754	7	.	.	.
cord-006860-a3b8hyyr	755	1	The	the	DT
cord-006860-a3b8hyyr	755	2	DNA	dna	NN
cord-006860-a3b8hyyr	755	3	analysis	analysis	NN
cord-006860-a3b8hyyr	755	4	was	be	VBD
cord-006860-a3b8hyyr	755	5	performed	perform	VBN
cord-006860-a3b8hyyr	755	6	as	as	IN
cord-006860-a3b8hyyr	755	7	described	describe	VBN
cord-006860-a3b8hyyr	755	8	by	by	IN
cord-006860-a3b8hyyr	755	9	Bertina	Bertina	NNP
cord-006860-a3b8hyyr	755	10	.	.	.
cord-006860-a3b8hyyr	756	1	One	one	CD
cord-006860-a3b8hyyr	756	2	patiem	patiem	NN
cord-006860-a3b8hyyr	756	3	was	be	VBD
cord-006860-a3b8hyyr	756	4	homozygoas	homozygoas	NN
cord-006860-a3b8hyyr	756	5	for	for	IN
cord-006860-a3b8hyyr	756	6	factor	factor	NN
cord-006860-a3b8hyyr	757	1	V	V	NNP
cord-006860-a3b8hyyr	757	2	mutstion~	mutstion~	NNP
cord-006860-a3b8hyyr	758	1	a	a	DT
cord-006860-a3b8hyyr	758	2	hetemzygous	hetemzygous	JJ
cord-006860-a3b8hyyr	758	3	result	result	NN
cord-006860-a3b8hyyr	758	4	was	be	VBD
cord-006860-a3b8hyyr	758	5	obtained	obtain	VBN
cord-006860-a3b8hyyr	758	6	in	in	IN
cord-006860-a3b8hyyr	758	7	4	4	CD
cord-006860-a3b8hyyr	758	8	members	member	NNS
cord-006860-a3b8hyyr	758	9	of	of	IN
cord-006860-a3b8hyyr	758	10	the	the	DT
cord-006860-a3b8hyyr	758	11	control	control	NN
cord-006860-a3b8hyyr	758	12	group	group	NN
cord-006860-a3b8hyyr	758	13	,	,	,
cord-006860-a3b8hyyr	758	14	in	in	IN
cord-006860-a3b8hyyr	758	15	28	28	CD
cord-006860-a3b8hyyr	758	16	patients	patient	NNS
cord-006860-a3b8hyyr	758	17	and	and	CC
cord-006860-a3b8hyyr	758	18	in	in	IN
cord-006860-a3b8hyyr	758	19	6	6	CD
cord-006860-a3b8hyyr	758	20	family	family	NN
cord-006860-a3b8hyyr	758	21	members	member	NNS
cord-006860-a3b8hyyr	758	22	.	.	.
cord-006860-a3b8hyyr	759	1	In	in	IN
cord-006860-a3b8hyyr	759	2	all	all	DT
cord-006860-a3b8hyyr	759	3	cases	case	NNS
cord-006860-a3b8hyyr	759	4	with	with	IN
cord-006860-a3b8hyyr	759	5	factor	factor	NN
cord-006860-a3b8hyyr	759	6	V	v	NN
cord-006860-a3b8hyyr	759	7	mutation	mutation	NN
cord-006860-a3b8hyyr	760	1	the	the	DT
cord-006860-a3b8hyyr	760	2	ratio	ratio	NN
cord-006860-a3b8hyyr	760	3	of	of	IN
cord-006860-a3b8hyyr	760	4	the	the	DT
cord-006860-a3b8hyyr	760	5	Immunochrom	Immunochrom	NNP
cord-006860-a3b8hyyr	760	6	assay	assay	NN
cord-006860-a3b8hyyr	760	7	was	be	VBD
cord-006860-a3b8hyyr	760	8	lower	low	JJR
cord-006860-a3b8hyyr	760	9	than	than	IN
cord-006860-a3b8hyyr	760	10	the	the	DT
cord-006860-a3b8hyyr	760	11	laboratory	laboratory	NN
cord-006860-a3b8hyyr	760	12	own	own	JJ
cord-006860-a3b8hyyr	760	13	value	value	NN
cord-006860-a3b8hyyr	760	14	,	,	,
cord-006860-a3b8hyyr	760	15	independent	independent	JJ
cord-006860-a3b8hyyr	760	16	on	on	IN
cord-006860-a3b8hyyr	760	17	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	760	18	therapy	therapy	NN
cord-006860-a3b8hyyr	760	19	.	.	.
cord-006860-a3b8hyyr	761	1	Pathological	pathological	JJ
cord-006860-a3b8hyyr	761	2	ratios	ratio	NNS
cord-006860-a3b8hyyr	761	3	in	in	IN
cord-006860-a3b8hyyr	761	4	this	this	DT
cord-006860-a3b8hyyr	761	5	assay	assay	NN
cord-006860-a3b8hyyr	761	6	were	be	VBD
cord-006860-a3b8hyyr	761	7	also	also	RB
cord-006860-a3b8hyyr	761	8	obtained	obtain	VBN
cord-006860-a3b8hyyr	761	9	in	in	IN
cord-006860-a3b8hyyr	761	10	one	one	CD
cord-006860-a3b8hyyr	761	11	member	member	NN
cord-006860-a3b8hyyr	761	12	of	of	IN
cord-006860-a3b8hyyr	761	13	a	a	DT
cord-006860-a3b8hyyr	761	14	family	family	NN
cord-006860-a3b8hyyr	761	15	"	"	''
cord-006860-a3b8hyyr	761	16	with	with	IN
cord-006860-a3b8hyyr	761	17	high	high	JJ
cord-006860-a3b8hyyr	761	18	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	761	19	incidence	incidence	NN
cord-006860-a3b8hyyr	761	20	(	(	-LRB-
cord-006860-a3b8hyyr	761	21	DNA	DNA	NNP
cord-006860-a3b8hyyr	761	22	Arg	arg	NN
cord-006860-a3b8hyyr	761	23	/	/	SYM
cord-006860-a3b8hyyr	761	24	Arg	arg	NN
cord-006860-a3b8hyyr	761	25	)	)	-RRB-
cord-006860-a3b8hyyr	761	26	and	and	CC
cord-006860-a3b8hyyr	761	27	in	in	IN
cord-006860-a3b8hyyr	761	28	17	17	CD
cord-006860-a3b8hyyr	761	29	patients	patient	NNS
cord-006860-a3b8hyyr	761	30	under	under	IN
cord-006860-a3b8hyyr	761	31	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	761	32	therapy	therapy	NN
cord-006860-a3b8hyyr	761	33	(	(	-LRB-
cord-006860-a3b8hyyr	761	34	two	two	CD
cord-006860-a3b8hyyr	761	35	of	of	IN
cord-006860-a3b8hyyr	761	36	this	this	DT
cord-006860-a3b8hyyr	761	37	patients	patient	NNS
cord-006860-a3b8hyyr	761	38	are	be	VBP
cord-006860-a3b8hyyr	761	39	one	one	CD
cord-006860-a3b8hyyr	761	40	cloned	clone	VBN
cord-006860-a3b8hyyr	761	41	twins	twin	NNS
cord-006860-a3b8hyyr	761	42	)	)	-RRB-
cord-006860-a3b8hyyr	761	43	.	.	.
cord-006860-a3b8hyyr	762	1	In	in	IN
cord-006860-a3b8hyyr	762	2	the	the	DT
cord-006860-a3b8hyyr	762	3	Contest	contest	NN
cord-006860-a3b8hyyr	762	4	a	a	DT
cord-006860-a3b8hyyr	762	5	AI~	AI~	NNP
cord-006860-a3b8hyyr	762	6	response	response	NN
cord-006860-a3b8hyyr	762	7	was	be	VBD
cord-006860-a3b8hyyr	762	8	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	762	9	in	in	IN
cord-006860-a3b8hyyr	762	10	all	all	DT
cord-006860-a3b8hyyr	762	11	cases	case	NNS
cord-006860-a3b8hyyr	762	12	with	with	IN
cord-006860-a3b8hyyr	762	13	factor	factor	NN
cord-006860-a3b8hyyr	762	14	V	v	NN
cord-006860-a3b8hyyr	762	15	mutation	mutation	NN
cord-006860-a3b8hyyr	762	16	without	without	IN
cord-006860-a3b8hyyr	762	17	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	762	18	therapy	therapy	NN
cord-006860-a3b8hyyr	762	19	and	and	CC
cord-006860-a3b8hyyr	762	20	in	in	IN
cord-006860-a3b8hyyr	762	21	40	40	CD
cord-006860-a3b8hyyr	762	22	%	%	NN
cord-006860-a3b8hyyr	762	23	of	of	IN
cord-006860-a3b8hyyr	762	24	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	762	25	patients	patient	NNS
cord-006860-a3b8hyyr	762	26	under	under	IN
cord-006860-a3b8hyyr	762	27	anticoaglant	anticoaglant	JJ
cord-006860-a3b8hyyr	762	28	therapy	therapy	NN
cord-006860-a3b8hyyr	762	29	.	.	.
cord-006860-a3b8hyyr	763	1	Results	result	NNS
cord-006860-a3b8hyyr	763	2	of	of	IN
cord-006860-a3b8hyyr	763	3	the	the	DT
cord-006860-a3b8hyyr	763	4	test	test	NN
cord-006860-a3b8hyyr	763	5	using	use	VBG
cord-006860-a3b8hyyr	763	6	the	the	DT
cord-006860-a3b8hyyr	763	7	dilution	dilution	NN
cord-006860-a3b8hyyr	763	8	in	in	IN
cord-006860-a3b8hyyr	763	9	factor	factor	NN
cord-006860-a3b8hyyr	763	10	V	v	NN
cord-006860-a3b8hyyr	763	11	deficient	deficient	JJ
cord-006860-a3b8hyyr	763	12	plasma	plasma	NN
cord-006860-a3b8hyyr	763	13	showed	show	VBD
cord-006860-a3b8hyyr	763	14	a	a	DT
cord-006860-a3b8hyyr	763	15	good	good	JJ
cord-006860-a3b8hyyr	763	16	agreement	agreement	NN
cord-006860-a3b8hyyr	763	17	vAth	vath	NN
cord-006860-a3b8hyyr	763	18	the	the	DT
cord-006860-a3b8hyyr	763	19	results	result	NNS
cord-006860-a3b8hyyr	763	20	of	of	IN
cord-006860-a3b8hyyr	763	21	the	the	DT
cord-006860-a3b8hyyr	763	22	DNA	dna	NN
cord-006860-a3b8hyyr	763	23	analysis	analysis	NN
cord-006860-a3b8hyyr	763	24	but	but	CC
cord-006860-a3b8hyyr	763	25	the	the	DT
cord-006860-a3b8hyyr	763	26	method	method	NN
cord-006860-a3b8hyyr	763	27	is	be	VBZ
cord-006860-a3b8hyyr	763	28	obviously	obviously	RB
cord-006860-a3b8hyyr	763	29	only	only	RB
cord-006860-a3b8hyyr	763	30	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	763	31	for	for	IN
cord-006860-a3b8hyyr	763	32	the	the	DT
cord-006860-a3b8hyyr	763	33	factor	factor	NN
cord-006860-a3b8hyyr	763	34	V	v	NN
cord-006860-a3b8hyyr	763	35	mutation	mutation	NN
cord-006860-a3b8hyyr	763	36	.	.	.
cord-006860-a3b8hyyr	764	1	The	the	DT
cord-006860-a3b8hyyr	764	2	reason	reason	NN
cord-006860-a3b8hyyr	764	3	for	for	IN
cord-006860-a3b8hyyr	764	4	pathogical	pathogical	JJ
cord-006860-a3b8hyyr	764	5	ratios	ratio	NNS
cord-006860-a3b8hyyr	764	6	in	in	IN
cord-006860-a3b8hyyr	764	7	the	the	DT
cord-006860-a3b8hyyr	764	8	lrnmunechrem	lrnmunechrem	NN
cord-006860-a3b8hyyr	764	9	assay	assay	NN
cord-006860-a3b8hyyr	764	10	in	in	IN
cord-006860-a3b8hyyr	764	11	wildtype	wildtype	JJ
cord-006860-a3b8hyyr	764	12	patients	patient	NNS
cord-006860-a3b8hyyr	764	13	is	be	VBZ
cord-006860-a3b8hyyr	764	14	unclear	unclear	JJ
cord-006860-a3b8hyyr	764	15	.	.	.
cord-006860-a3b8hyyr	765	1	The	the	DT
cord-006860-a3b8hyyr	765	2	majority	majority	NN
cord-006860-a3b8hyyr	765	3	of	of	IN
cord-006860-a3b8hyyr	765	4	this	this	DT
cord-006860-a3b8hyyr	765	5	patients	patient	NNS
cord-006860-a3b8hyyr	765	6	is	be	VBZ
cord-006860-a3b8hyyr	765	7	treated	treat	VBN
cord-006860-a3b8hyyr	765	8	with	with	IN
cord-006860-a3b8hyyr	765	9	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	765	10	,	,	,
cord-006860-a3b8hyyr	765	11	a	a	DT
cord-006860-a3b8hyyr	765	12	comparison	comparison	NN
cord-006860-a3b8hyyr	765	13	with	with	IN
cord-006860-a3b8hyyr	765	14	the	the	DT
cord-006860-a3b8hyyr	765	15	Contest	contest	NN
cord-006860-a3b8hyyr	765	16	is	be	VBZ
cord-006860-a3b8hyyr	765	17	not	not	RB
cord-006860-a3b8hyyr	765	18	possible	possible	JJ
cord-006860-a3b8hyyr	765	19	.	.	.
cord-006860-a3b8hyyr	766	1	Interestingly	interestingly	RB
cord-006860-a3b8hyyr	766	2	in	in	IN
cord-006860-a3b8hyyr	766	3	one	one	CD
cord-006860-a3b8hyyr	766	4	patient	patient	NN
cord-006860-a3b8hyyr	766	5	under	under	IN
cord-006860-a3b8hyyr	766	6	heparin	heparin	NN
cord-006860-a3b8hyyr	766	7	and	and	CC
cord-006860-a3b8hyyr	766	8	low	low	JJ
cord-006860-a3b8hyyr	766	9	ratio	ratio	NN
cord-006860-a3b8hyyr	766	10	in	in	IN
cord-006860-a3b8hyyr	766	11	the	the	DT
cord-006860-a3b8hyyr	766	12	Immunochrom	Immunochrom	NNP
cord-006860-a3b8hyyr	766	13	assay	assay	NN
cord-006860-a3b8hyyr	766	14	'	'	''
cord-006860-a3b8hyyr	766	15	after	after	IN
cord-006860-a3b8hyyr	766	16	reduction	reduction	NN
cord-006860-a3b8hyyr	766	17	of	of	IN
cord-006860-a3b8hyyr	766	18	hepann	hepann	NNP
cord-006860-a3b8hyyr	766	19	the	the	DT
cord-006860-a3b8hyyr	766	20	ratio	ratio	NN
cord-006860-a3b8hyyr	766	21	of	of	IN
cord-006860-a3b8hyyr	766	22	the	the	DT
cord-006860-a3b8hyyr	766	23	Coatest	Coatest	NNP
cord-006860-a3b8hyyr	766	24	was	be	VBD
cord-006860-a3b8hyyr	766	25	also	also	RB
cord-006860-a3b8hyyr	766	26	low	low	JJ
cord-006860-a3b8hyyr	766	27	.	.	.
cord-006860-a3b8hyyr	767	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	767	2	seems	seem	VBZ
cord-006860-a3b8hyyr	767	3	necessary	necessary	JJ
cord-006860-a3b8hyyr	767	4	to	to	TO
cord-006860-a3b8hyyr	767	5	investigate	investigate	VB
cord-006860-a3b8hyyr	767	6	in	in	IN
cord-006860-a3b8hyyr	767	7	which	which	WDT
cord-006860-a3b8hyyr	767	8	distance	distance	NN
cord-006860-a3b8hyyr	767	9	to	to	IN
cord-006860-a3b8hyyr	767	10	the	the	DT
cord-006860-a3b8hyyr	767	11	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	767	12	events	event	NNS
cord-006860-a3b8hyyr	767	13	the	the	DT
cord-006860-a3b8hyyr	767	14	APC	APC	NNP
cord-006860-a3b8hyyr	767	15	resistance	resistance	NN
cord-006860-a3b8hyyr	767	16	should	should	MD
cord-006860-a3b8hyyr	767	17	be	be	VB
cord-006860-a3b8hyyr	767	18	tested	test	VBN
cord-006860-a3b8hyyr	767	19	.	.	.
cord-006860-a3b8hyyr	768	1	Following	follow	VBG
cord-006860-a3b8hyyr	768	2	pathological	pathological	JJ
cord-006860-a3b8hyyr	768	3	ratios	ratio	NNS
cord-006860-a3b8hyyr	768	4	in	in	IN
cord-006860-a3b8hyyr	768	5	ftmctional	ftmctional	JJ
cord-006860-a3b8hyyr	768	6	APC	APC	NNP
cord-006860-a3b8hyyr	768	7	assays	assay	NNS
cord-006860-a3b8hyyr	768	8	must	must	MD
cord-006860-a3b8hyyr	768	9	be	be	VB
cord-006860-a3b8hyyr	768	10	discussed	discuss	VBN
cord-006860-a3b8hyyr	768	11	:	:	:
cord-006860-a3b8hyyr	768	12	high	high	JJ
cord-006860-a3b8hyyr	768	13	levels	level	NNS
cord-006860-a3b8hyyr	768	14	of	of	IN
cord-006860-a3b8hyyr	768	15	factor	factor	NN
cord-006860-a3b8hyyr	768	16	VIII	VIII	NNP
cord-006860-a3b8hyyr	768	17	and	and	CC
cord-006860-a3b8hyyr	768	18	or	or	CC
cord-006860-a3b8hyyr	768	19	v	v	LS
cord-006860-a3b8hyyr	768	20	WiUebrand	WiUebrand	NNP
cord-006860-a3b8hyyr	768	21	antigen	antigen	NN
cord-006860-a3b8hyyr	768	22	(	(	-LRB-
cord-006860-a3b8hyyr	768	23	acute	acute	JJ
cord-006860-a3b8hyyr	768	24	phase	phase	NN
cord-006860-a3b8hyyr	768	25	reactien	reactien	NNP
cord-006860-a3b8hyyr	768	26	)	)	-RRB-
cord-006860-a3b8hyyr	768	27	,	,	,
cord-006860-a3b8hyyr	768	28	other	other	JJ
cord-006860-a3b8hyyr	768	29	mutations	mutation	NNS
cord-006860-a3b8hyyr	768	30	in	in	IN
cord-006860-a3b8hyyr	768	31	factor	factor	NN
cord-006860-a3b8hyyr	768	32	V	v	NN
cord-006860-a3b8hyyr	768	33	and	and	CC
cord-006860-a3b8hyyr	768	34	VIII	VIII	NNP
cord-006860-a3b8hyyr	768	35	.	.	.
cord-006860-a3b8hyyr	769	1	The	the	DT
cord-006860-a3b8hyyr	769	2	factor	factor	NN
cord-006860-a3b8hyyr	769	3	V	v	NN
cord-006860-a3b8hyyr	769	4	dilution	dilution	NN
cord-006860-a3b8hyyr	769	5	assay	assay	NN
cord-006860-a3b8hyyr	769	6	should	should	MD
cord-006860-a3b8hyyr	769	7	be	be	VB
cord-006860-a3b8hyyr	769	8	replaced	replace	VBN
cord-006860-a3b8hyyr	769	9	by	by	IN
cord-006860-a3b8hyyr	769	10	the	the	DT
cord-006860-a3b8hyyr	769	11	DNA	dna	NN
cord-006860-a3b8hyyr	769	12	analysis	analysis	NN
cord-006860-a3b8hyyr	769	13	.	.	.
cord-006860-a3b8hyyr	770	1	Due	due	IN
cord-006860-a3b8hyyr	770	2	to	to	IN
cord-006860-a3b8hyyr	770	3	their	-PRON-	PRP$
cord-006860-a3b8hyyr	770	4	differing	differ	VBG
cord-006860-a3b8hyyr	770	5	compositions	composition	NNS
cord-006860-a3b8hyyr	770	6	,	,	,
cord-006860-a3b8hyyr	770	7	the	the	DT
cord-006860-a3b8hyyr	770	8	"	"	``
cord-006860-a3b8hyyr	770	9	sensitivities	sensitivity	NNS
cord-006860-a3b8hyyr	770	10	"	"	''
cord-006860-a3b8hyyr	770	11	of	of	IN
cord-006860-a3b8hyyr	770	12	various	various	JJ
cord-006860-a3b8hyyr	770	13	APTF	aptf	NN
cord-006860-a3b8hyyr	770	14	reagealts	reagealt	NNS
cord-006860-a3b8hyyr	770	15	differ	differ	VBP
cord-006860-a3b8hyyr	770	16	not	not	RB
cord-006860-a3b8hyyr	770	17	only	only	RB
cord-006860-a3b8hyyr	770	18	with	with	IN
cord-006860-a3b8hyyr	770	19	respect	respect	NN
cord-006860-a3b8hyyr	770	20	to	to	IN
cord-006860-a3b8hyyr	770	21	factor	factor	NN
cord-006860-a3b8hyyr	770	22	depletions	depletion	NNS
cord-006860-a3b8hyyr	770	23	,	,	,
cord-006860-a3b8hyyr	770	24	heparin	heparin	NN
cord-006860-a3b8hyyr	770	25	and	and	CC
cord-006860-a3b8hyyr	770	26	fibrin	fibrin	NN
cord-006860-a3b8hyyr	770	27	-	-	HYPH
cord-006860-a3b8hyyr	770	28	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	770	29	degradation	degradation	NN
cord-006860-a3b8hyyr	770	30	products	product	NNS
cord-006860-a3b8hyyr	770	31	,	,	,
cord-006860-a3b8hyyr	770	32	but	but	CC
cord-006860-a3b8hyyr	770	33	also	also	RB
cord-006860-a3b8hyyr	770	34	with	with	IN
cord-006860-a3b8hyyr	770	35	regard	regard	NN
cord-006860-a3b8hyyr	770	36	to	to	IN
cord-006860-a3b8hyyr	770	37	pathological	pathological	JJ
cord-006860-a3b8hyyr	770	38	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	770	39	.	.	.
cord-006860-a3b8hyyr	771	1	For	for	IN
cord-006860-a3b8hyyr	771	2	lupus	lupus	NN
cord-006860-a3b8hyyr	771	3	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	771	4	this	this	DT
cord-006860-a3b8hyyr	771	5	means	mean	VBZ
cord-006860-a3b8hyyr	771	6	that	that	IN
cord-006860-a3b8hyyr	771	7	"	"	``
cord-006860-a3b8hyyr	771	8	lupus	lupus	NN
cord-006860-a3b8hyyr	771	9	-	-	HYPH
cord-006860-a3b8hyyr	771	10	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	771	11	"	"	''
cord-006860-a3b8hyyr	771	12	reagents	reagent	NNS
cord-006860-a3b8hyyr	771	13	can	can	MD
cord-006860-a3b8hyyr	771	14	be	be	VB
cord-006860-a3b8hyyr	771	15	delineated	delineate	VBN
cord-006860-a3b8hyyr	771	16	from	from	IN
cord-006860-a3b8hyyr	771	17	"	"	``
cord-006860-a3b8hyyr	771	18	lupus	lupus	NN
cord-006860-a3b8hyyr	771	19	-	-	HYPH
cord-006860-a3b8hyyr	771	20	insensitive	insensitive	JJ
cord-006860-a3b8hyyr	771	21	"	"	''
cord-006860-a3b8hyyr	771	22	reagents	reagent	NNS
cord-006860-a3b8hyyr	771	23	.	.	.
cord-006860-a3b8hyyr	772	1	With	with	IN
cord-006860-a3b8hyyr	772	2	a	a	DT
cord-006860-a3b8hyyr	772	3	"	"	``
cord-006860-a3b8hyyr	772	4	lupus	lupus	NN
cord-006860-a3b8hyyr	772	5	-	-	HYPH
cord-006860-a3b8hyyr	772	6	insensitive	insensitive	JJ
cord-006860-a3b8hyyr	772	7	"	"	''
cord-006860-a3b8hyyr	772	8	AI~	ai~	NN
cord-006860-a3b8hyyr	772	9	reagent	reagent	NN
cord-006860-a3b8hyyr	772	10	there	there	EX
cord-006860-a3b8hyyr	772	11	is	be	VBZ
cord-006860-a3b8hyyr	772	12	no	no	DT
cord-006860-a3b8hyyr	772	13	or	or	CC
cord-006860-a3b8hyyr	772	14	only	only	JJ
cord-006860-a3b8hyyr	772	15	slight	slight	JJ
cord-006860-a3b8hyyr	772	16	prolongation	prolongation	NN
cord-006860-a3b8hyyr	772	17	of	of	IN
cord-006860-a3b8hyyr	772	18	the	the	DT
cord-006860-a3b8hyyr	772	19	APTT	APTT	NNP
cord-006860-a3b8hyyr	772	20	in	in	IN
cord-006860-a3b8hyyr	772	21	the	the	DT
cord-006860-a3b8hyyr	772	22	plasma	plasma	NN
cord-006860-a3b8hyyr	772	23	under	under	IN
cord-006860-a3b8hyyr	772	24	investigation	investigation	NN
cord-006860-a3b8hyyr	772	25	,	,	,
cord-006860-a3b8hyyr	772	26	whereas	whereas	IN
cord-006860-a3b8hyyr	772	27	with	with	IN
cord-006860-a3b8hyyr	772	28	a	a	DT
cord-006860-a3b8hyyr	772	29	"	"	``
cord-006860-a3b8hyyr	772	30	lupus	lupus	NN
cord-006860-a3b8hyyr	772	31	-	-	HYPH
cord-006860-a3b8hyyr	772	32	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	772	33	"	"	''
cord-006860-a3b8hyyr	772	34	reagent	reagent	NN
cord-006860-a3b8hyyr	772	35	marked	mark	VBN
cord-006860-a3b8hyyr	772	36	prolongation	prolongation	NN
cord-006860-a3b8hyyr	772	37	is	be	VBZ
cord-006860-a3b8hyyr	772	38	observed	observe	VBN
cord-006860-a3b8hyyr	772	39	.	.	.
cord-006860-a3b8hyyr	773	1	For	for	IN
cord-006860-a3b8hyyr	773	2	the	the	DT
cord-006860-a3b8hyyr	773	3	meaninof	meaninof	NNS
cord-006860-a3b8hyyr	773	4	~	~	NFP
cord-006860-a3b8hyyr	773	5	l	l	NN
cord-006860-a3b8hyyr	773	6	use	use	NN
cord-006860-a3b8hyyr	773	7	of	of	IN
cord-006860-a3b8hyyr	773	8	APTr	APTr	NNS
cord-006860-a3b8hyyr	773	9	reagents	reagent	NNS
cord-006860-a3b8hyyr	773	10	it	-PRON-	PRP
cord-006860-a3b8hyyr	773	11	is	be	VBZ
cord-006860-a3b8hyyr	773	12	necessary	necessary	JJ
cord-006860-a3b8hyyr	773	13	to	to	TO
cord-006860-a3b8hyyr	773	14	know	know	VB
cord-006860-a3b8hyyr	773	15	the	the	DT
cord-006860-a3b8hyyr	773	16	extent	extent	NN
cord-006860-a3b8hyyr	773	17	to	to	TO
cord-006860-a3b8hyyr	773	18	which	which	WDT
cord-006860-a3b8hyyr	773	19	they	-PRON-	PRP
cord-006860-a3b8hyyr	773	20	are	be	VBP
cord-006860-a3b8hyyr	773	21	influenced	influence	VBN
cord-006860-a3b8hyyr	773	22	by	by	IN
cord-006860-a3b8hyyr	773	23	lupus	lupus	NN
cord-006860-a3b8hyyr	773	24	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	773	25	.	.	.
cord-006860-a3b8hyyr	774	1	The	the	DT
cord-006860-a3b8hyyr	774	2	following	follow	VBG
cord-006860-a3b8hyyr	774	3	14	14	CD
cord-006860-a3b8hyyr	774	4	APTI	APTI	NNP
cord-006860-a3b8hyyr	774	5	'	'	POS
cord-006860-a3b8hyyr	774	6	reagents	reagent	NNS
cord-006860-a3b8hyyr	774	7	were	be	VBD
cord-006860-a3b8hyyr	774	8	tested	test	VBN
cord-006860-a3b8hyyr	774	9	:	:	:
cord-006860-a3b8hyyr	774	10	•	•	NNP
cord-006860-a3b8hyyr	774	11	PTT	PTT	NNP
cord-006860-a3b8hyyr	774	12	-	-	HYPH
cord-006860-a3b8hyyr	774	13	Reageaz	Reageaz	NNPS
cord-006860-a3b8hyyr	774	14	,	,	,
cord-006860-a3b8hyyr	774	15	P'rTa	P'rTa	NNPS
cord-006860-a3b8hyyr	774	16	,	,	,
cord-006860-a3b8hyyr	774	17	PTTa	PTTa	NNP
cord-006860-a3b8hyyr	774	18	liquid	liquid	NN
cord-006860-a3b8hyyr	774	19	,	,	,
cord-006860-a3b8hyyr	774	20	PTT	PTT	NNP
cord-006860-a3b8hyyr	774	21	-	-	HYPH
cord-006860-a3b8hyyr	774	22	LA	LA	NNP
cord-006860-a3b8hyyr	774	23	,	,	,
cord-006860-a3b8hyyr	774	24	PTI'-LT	PTI'-LT	NNP
cord-006860-a3b8hyyr	774	25	(	(	-LRB-
cord-006860-a3b8hyyr	774	26	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	774	27	/	/	SYM
cord-006860-a3b8hyyr	774	28	Stago	Stago	NNP
cord-006860-a3b8hyyr	774	29	)	)	-RRB-
cord-006860-a3b8hyyr	775	1	•	•	NNP
cord-006860-a3b8hyyr	776	1	Pathromtin	Pathromtin	NNP
cord-006860-a3b8hyyr	776	2	,	,	,
cord-006860-a3b8hyyr	776	3	Pathromfin	Pathromfin	NNP
cord-006860-a3b8hyyr	776	4	SL	SL	NNP
cord-006860-a3b8hyyr	776	5	,	,	,
cord-006860-a3b8hyyr	776	6	Necthroratin	Necthroratin	NNP
cord-006860-a3b8hyyr	776	7	(	(	-LRB-
cord-006860-a3b8hyyr	776	8	Behring	Behring	NNP
cord-006860-a3b8hyyr	776	9	)	)	-RRB-
cord-006860-a3b8hyyr	777	1	•	•	NNP
cord-006860-a3b8hyyr	778	1	Platelin	Platelin	NNP
cord-006860-a3b8hyyr	778	2	S	S	NNP
cord-006860-a3b8hyyr	778	3	,	,	,
cord-006860-a3b8hyyr	778	4	PIatehn	PIatehn	NNP
cord-006860-a3b8hyyr	778	5	Excel	Excel	NNP
cord-006860-a3b8hyyr	778	6	LS	LS	NNP
cord-006860-a3b8hyyr	778	7	(	(	-LRB-
cord-006860-a3b8hyyr	778	8	Organon	Organon	NNP
cord-006860-a3b8hyyr	778	9	Tekinka	Tekinka	NNP
cord-006860-a3b8hyyr	778	10	)	)	-RRB-
cord-006860-a3b8hyyr	779	1	•	•	NNP
cord-006860-a3b8hyyr	780	1	Actin	Actin	NNP
cord-006860-a3b8hyyr	780	2	-	-	HYPH
cord-006860-a3b8hyyr	780	3	FS	FS	NNP
cord-006860-a3b8hyyr	780	4	,	,	,
cord-006860-a3b8hyyr	780	5	Actin	Actin	NNP
cord-006860-a3b8hyyr	780	6	-	-	HYPH
cord-006860-a3b8hyyr	780	7	FSL	FSL	NNP
cord-006860-a3b8hyyr	780	8	(	(	-LRB-
cord-006860-a3b8hyyr	780	9	Dade	Dade	NNP
cord-006860-a3b8hyyr	780	10	)	)	-RRB-
cord-006860-a3b8hyyr	781	1	•	•	NNP
cord-006860-a3b8hyyr	782	1	APTT	APTT	NNP
cord-006860-a3b8hyyr	782	2	silica	silica	NN
cord-006860-a3b8hyyr	782	3	lye	lye	NN
cord-006860-a3b8hyyr	782	4	,	,	,
cord-006860-a3b8hyyr	782	5	APTT	APTT	NNP
cord-006860-a3b8hyyr	782	6	silica	silica	NN
cord-006860-a3b8hyyr	782	7	liquid	liquid	NN
cord-006860-a3b8hyyr	782	8	(	(	-LRB-
cord-006860-a3b8hyyr	782	9	Instntmentation	Instntmentation	NNP
cord-006860-a3b8hyyr	782	10	Laboratory	Laboratory	NNP
cord-006860-a3b8hyyr	782	11	)	)	-RRB-
cord-006860-a3b8hyyr	783	1	The	the	DT
cord-006860-a3b8hyyr	783	2	material	material	NN
cord-006860-a3b8hyyr	783	3	for	for	IN
cord-006860-a3b8hyyr	783	4	investigation	investigation	NN
cord-006860-a3b8hyyr	783	5	consisted	consist	VBD
cord-006860-a3b8hyyr	783	6	of	of	IN
cord-006860-a3b8hyyr	783	7	20	20	CD
cord-006860-a3b8hyyr	783	8	plasmas	plasma	NNS
cord-006860-a3b8hyyr	783	9	from	from	IN
cord-006860-a3b8hyyr	783	10	patients	patient	NNS
cord-006860-a3b8hyyr	783	11	with	with	IN
cord-006860-a3b8hyyr	783	12	lupus	lupus	NN
cord-006860-a3b8hyyr	783	13	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	783	14	.	.	.
cord-006860-a3b8hyyr	784	1	A	a	DT
cord-006860-a3b8hyyr	784	2	confirmatory	confirmatory	JJ
cord-006860-a3b8hyyr	784	3	test	test	NN
cord-006860-a3b8hyyr	784	4	(	(	-LRB-
cord-006860-a3b8hyyr	784	5	Lupus	lupus	JJ
cord-006860-a3b8hyyr	784	6	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	784	7	test	test	NN
cord-006860-a3b8hyyr	784	8	,	,	,
cord-006860-a3b8hyyr	784	9	Immune	Immune	NNP
cord-006860-a3b8hyyr	784	10	)	)	-RRB-
cord-006860-a3b8hyyr	784	11	was	be	VBD
cord-006860-a3b8hyyr	784	12	positive	positive	JJ
cord-006860-a3b8hyyr	784	13	for	for	IN
cord-006860-a3b8hyyr	784	14	all	all	DT
cord-006860-a3b8hyyr	784	15	of	of	IN
cord-006860-a3b8hyyr	784	16	the	the	DT
cord-006860-a3b8hyyr	784	17	patients	patient	NNS
cord-006860-a3b8hyyr	784	18	.	.	.
cord-006860-a3b8hyyr	785	1	Measurements	measurement	NNS
cord-006860-a3b8hyyr	785	2	were	be	VBD
cord-006860-a3b8hyyr	785	3	made	make	VBN
cord-006860-a3b8hyyr	785	4	using	use	VBG
cord-006860-a3b8hyyr	785	5	the	the	DT
cord-006860-a3b8hyyr	785	6	STA	STA	NNP
cord-006860-a3b8hyyr	785	7	coagulation	coagulation	NN
cord-006860-a3b8hyyr	785	8	analyser	analyser	NN
cord-006860-a3b8hyyr	785	9	(	(	-LRB-
cord-006860-a3b8hyyr	785	10	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	785	11	/	/	SYM
cord-006860-a3b8hyyr	785	12	Stago	Stago	NNP
cord-006860-a3b8hyyr	785	13	)	)	-RRB-
cord-006860-a3b8hyyr	785	14	.	.	.
cord-006860-a3b8hyyr	786	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	786	2	can	can	MD
cord-006860-a3b8hyyr	786	3	be	be	VB
cord-006860-a3b8hyyr	786	4	seen	see	VBN
cord-006860-a3b8hyyr	786	5	from	from	IN
cord-006860-a3b8hyyr	786	6	the	the	DT
cord-006860-a3b8hyyr	786	7	results	result	NNS
cord-006860-a3b8hyyr	786	8	that	that	IN
cord-006860-a3b8hyyr	786	9	in	in	IN
cord-006860-a3b8hyyr	786	10	some	some	DT
cord-006860-a3b8hyyr	786	11	instances	instance	NNS
cord-006860-a3b8hyyr	786	12	very	very	RB
cord-006860-a3b8hyyr	786	13	different	different	JJ
cord-006860-a3b8hyyr	786	14	prolongations	prolongation	NNS
cord-006860-a3b8hyyr	786	15	were	be	VBD
cord-006860-a3b8hyyr	786	16	obtained	obtain	VBN
cord-006860-a3b8hyyr	786	17	in	in	IN
cord-006860-a3b8hyyr	786	18	identical	identical	JJ
cord-006860-a3b8hyyr	786	19	plasmas	plasma	NNS
cord-006860-a3b8hyyr	786	20	by	by	IN
cord-006860-a3b8hyyr	786	21	using	use	VBG
cord-006860-a3b8hyyr	786	22	differing	differ	VBG
cord-006860-a3b8hyyr	786	23	APTT	APTT	NNP
cord-006860-a3b8hyyr	786	24	reagents	reagent	NNS
cord-006860-a3b8hyyr	786	25	.	.	.
cord-006860-a3b8hyyr	787	1	Low	low	JJ
cord-006860-a3b8hyyr	787	2	susceptibility	susceptibility	NN
cord-006860-a3b8hyyr	787	3	to	to	IN
cord-006860-a3b8hyyr	787	4	lupus	lupus	NN
cord-006860-a3b8hyyr	787	5	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	787	6	was	be	VBD
cord-006860-a3b8hyyr	787	7	shown	show	VBN
cord-006860-a3b8hyyr	787	8	by	by	IN
cord-006860-a3b8hyyr	787	9	Actirt	Actirt	NNP
cord-006860-a3b8hyyr	787	10	FS	FS	NNP
cord-006860-a3b8hyyr	787	11	(	(	-LRB-
cord-006860-a3b8hyyr	787	12	Dade	Dade	NNP
cord-006860-a3b8hyyr	787	13	)	)	-RRB-
cord-006860-a3b8hyyr	787	14	,	,	,
cord-006860-a3b8hyyr	787	15	PTT	PTT	NNP
cord-006860-a3b8hyyr	787	16	-	-	HYPH
cord-006860-a3b8hyyr	787	17	Reagenz	Reagenz	NNP
cord-006860-a3b8hyyr	787	18	(	(	-LRB-
cord-006860-a3b8hyyr	787	19	Bcehrlnger	Bcehrlnger	NNP
cord-006860-a3b8hyyr	787	20	)	)	-RRB-
cord-006860-a3b8hyyr	787	21	and	and	CC
cord-006860-a3b8hyyr	787	22	Neothromfin	Neothromfin	NNP
cord-006860-a3b8hyyr	787	23	(	(	-LRB-
cord-006860-a3b8hyyr	787	24	Behring	Behring	NNP
cord-006860-a3b8hyyr	787	25	)	)	-RRB-
cord-006860-a3b8hyyr	787	26	.	.	.
cord-006860-a3b8hyyr	788	1	High	high	JJ
cord-006860-a3b8hyyr	788	2	susceptibility	susceptibility	NN
cord-006860-a3b8hyyr	788	3	was	be	VBD
cord-006860-a3b8hyyr	788	4	shown	show	VBN
cord-006860-a3b8hyyr	788	5	by	by	IN
cord-006860-a3b8hyyr	788	6	Platetin	Platetin	NNP
cord-006860-a3b8hyyr	788	7	Excel	Excel	NNP
cord-006860-a3b8hyyr	788	8	LS	LS	NNP
cord-006860-a3b8hyyr	788	9	(	(	-LRB-
cord-006860-a3b8hyyr	788	10	Organon	Organon	NNP
cord-006860-a3b8hyyr	788	11	Teknika	Teknika	NNP
cord-006860-a3b8hyyr	788	12	)	)	-RRB-
cord-006860-a3b8hyyr	788	13	,	,	,
cord-006860-a3b8hyyr	788	14	PTT	PTT	NNP
cord-006860-a3b8hyyr	788	15	-	-	HYPH
cord-006860-a3b8hyyr	788	16	LA	LA	NNP
cord-006860-a3b8hyyr	788	17	and	and	CC
cord-006860-a3b8hyyr	788	18	PTI'-LT	PTI'-LT	NNP
cord-006860-a3b8hyyr	788	19	(	(	-LRB-
cord-006860-a3b8hyyr	788	20	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	788	21	/	/	SYM
cord-006860-a3b8hyyr	788	22	Stago	Stago	NNP
cord-006860-a3b8hyyr	788	23	)	)	-RRB-
cord-006860-a3b8hyyr	788	24	.	.	.
cord-006860-a3b8hyyr	789	1	Lupus	lupus	JJ
cord-006860-a3b8hyyr	789	2	anticoaguhant	anticoaguhant	NN
cord-006860-a3b8hyyr	789	3	screening	screening	NN
cord-006860-a3b8hyyr	789	4	with	with	IN
cord-006860-a3b8hyyr	789	5	the	the	DT
cord-006860-a3b8hyyr	789	6	APTT	APTT	NNP
cord-006860-a3b8hyyr	789	7	reaction	reaction	NN
cord-006860-a3b8hyyr	789	8	is	be	VBZ
cord-006860-a3b8hyyr	789	9	promising	promise	VBG
cord-006860-a3b8hyyr	789	10	when	when	WRB
cord-006860-a3b8hyyr	789	11	two	two	CD
cord-006860-a3b8hyyr	789	12	APTr	aptr	NN
cord-006860-a3b8hyyr	789	13	reagents	reagent	NNS
cord-006860-a3b8hyyr	789	14	differing	differ	VBG
cord-006860-a3b8hyyr	789	15	as	as	RB
cord-006860-a3b8hyyr	789	16	greatly	greatly	RB
cord-006860-a3b8hyyr	789	17	as	as	IN
cord-006860-a3b8hyyr	789	18	possible	possible	JJ
cord-006860-a3b8hyyr	789	19	in	in	IN
cord-006860-a3b8hyyr	789	20	their	-PRON-	PRP$
cord-006860-a3b8hyyr	789	21	lupus	lupus	NN
cord-006860-a3b8hyyr	789	22	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	789	23	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	789	24	are	be	VBP
cord-006860-a3b8hyyr	789	25	used	use	VBN
cord-006860-a3b8hyyr	789	26	.	.	.
cord-006860-a3b8hyyr	790	1	The	the	DT
cord-006860-a3b8hyyr	790	2	resistance	resistance	NN
cord-006860-a3b8hyyr	790	3	to	to	IN
cord-006860-a3b8hyyr	790	4	the	the	DT
cord-006860-a3b8hyyr	790	5	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	790	6	response	response	NN
cord-006860-a3b8hyyr	790	7	of	of	IN
cord-006860-a3b8hyyr	790	8	activated	activate	VBN
cord-006860-a3b8hyyr	790	9	protein	protein	NN
cord-006860-a3b8hyyr	790	10	C	C	NNP
cord-006860-a3b8hyyr	790	11	(	(	-LRB-
cord-006860-a3b8hyyr	790	12	APC	APC	NNP
cord-006860-a3b8hyyr	790	13	)	)	-RRB-
cord-006860-a3b8hyyr	790	14	is	be	VBZ
cord-006860-a3b8hyyr	790	15	a	a	DT
cord-006860-a3b8hyyr	790	16	major	major	JJ
cord-006860-a3b8hyyr	790	17	cause	cause	NN
cord-006860-a3b8hyyr	790	18	of	of	IN
cord-006860-a3b8hyyr	790	19	venous	venous	JJ
cord-006860-a3b8hyyr	790	20	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	790	21	.	.	.
cord-006860-a3b8hyyr	791	1	APCresistance	apcresistance	NN
cord-006860-a3b8hyyr	791	2	is	be	VBZ
cord-006860-a3b8hyyr	791	3	due	due	JJ
cord-006860-a3b8hyyr	791	4	to	to	IN
cord-006860-a3b8hyyr	791	5	a	a	DT
cord-006860-a3b8hyyr	791	6	single	single	JJ
cord-006860-a3b8hyyr	791	7	mutation	mutation	NN
cord-006860-a3b8hyyr	791	8	in	in	IN
cord-006860-a3b8hyyr	791	9	factor	factor	NN
cord-006860-a3b8hyyr	791	10	V	v	NN
cord-006860-a3b8hyyr	791	11	gene	gene	NN
cord-006860-a3b8hyyr	791	12	,	,	,
cord-006860-a3b8hyyr	791	13	which	which	WDT
cord-006860-a3b8hyyr	791	14	predicts	predict	VBZ
cord-006860-a3b8hyyr	791	15	replacement	replacement	NN
cord-006860-a3b8hyyr	791	16	of	of	IN
cord-006860-a3b8hyyr	791	17	Arg	Arg	NNP
cord-006860-a3b8hyyr	791	18	560	560	CD
cord-006860-a3b8hyyr	791	19	in	in	IN
cord-006860-a3b8hyyr	791	20	the	the	DT
cord-006860-a3b8hyyr	791	21	APC	APC	NNP
cord-006860-a3b8hyyr	791	22	-	-	HYPH
cord-006860-a3b8hyyr	791	23	cleavage	cleavage	NN
cord-006860-a3b8hyyr	791	24	site	site	NN
cord-006860-a3b8hyyr	791	25	with	with	IN
cord-006860-a3b8hyyr	791	26	Gln	Gln	NNP
cord-006860-a3b8hyyr	791	27	(	(	-LRB-
cord-006860-a3b8hyyr	791	28	Factor	factor	NN
cord-006860-a3b8hyyr	791	29	V	V	NNP
cord-006860-a3b8hyyr	791	30	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	791	31	mutation	mutation	NN
cord-006860-a3b8hyyr	791	32	)	)	-RRB-
cord-006860-a3b8hyyr	791	33	.	.	.
cord-006860-a3b8hyyr	792	1	In	in	IN
cord-006860-a3b8hyyr	792	2	contrast	contrast	NN
cord-006860-a3b8hyyr	792	3	to	to	IN
cord-006860-a3b8hyyr	792	4	other	other	JJ
cord-006860-a3b8hyyr	792	5	known	know	VBN
cord-006860-a3b8hyyr	792	6	genetic	genetic	JJ
cord-006860-a3b8hyyr	792	7	risk	risk	NN
cord-006860-a3b8hyyr	792	8	factors	factor	NNS
cord-006860-a3b8hyyr	792	9	for	for	IN
cord-006860-a3b8hyyr	792	10	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	792	11	,	,	,
cord-006860-a3b8hyyr	792	12	this	this	DT
cord-006860-a3b8hyyr	792	13	Factor	factor	NN
cord-006860-a3b8hyyr	792	14	V	v	NN
cord-006860-a3b8hyyr	792	15	1691	1691	CD
cord-006860-a3b8hyyr	792	16	G	g	NN
cord-006860-a3b8hyyr	792	17	-	-	HYPH
cord-006860-a3b8hyyr	792	18	A	a	DT
cord-006860-a3b8hyyr	792	19	mutation	mutation	NN
cord-006860-a3b8hyyr	792	20	has	have	VBZ
cord-006860-a3b8hyyr	792	21	a	a	DT
cord-006860-a3b8hyyr	792	22	high	high	JJ
cord-006860-a3b8hyyr	792	23	prevalence	prevalence	NN
cord-006860-a3b8hyyr	792	24	in	in	IN
cord-006860-a3b8hyyr	792	25	the	the	DT
cord-006860-a3b8hyyr	792	26	common	common	JJ
cord-006860-a3b8hyyr	792	27	population	population	NN
cord-006860-a3b8hyyr	792	28	of	of	IN
cord-006860-a3b8hyyr	792	29	Western	Western	NNP
cord-006860-a3b8hyyr	792	30	Europe	Europe	NNP
cord-006860-a3b8hyyr	792	31	(	(	-LRB-
cord-006860-a3b8hyyr	792	32	average	average	JJ
cord-006860-a3b8hyyr	792	33	4	4	CD
cord-006860-a3b8hyyr	792	34	-	-	SYM
cord-006860-a3b8hyyr	792	35	5	5	CD
cord-006860-a3b8hyyr	792	36	%	%	NN
cord-006860-a3b8hyyr	792	37	)	)	-RRB-
cord-006860-a3b8hyyr	792	38	.	.	.
cord-006860-a3b8hyyr	793	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	793	2	have	have	VBP
cord-006860-a3b8hyyr	793	3	determined	determine	VBN
cord-006860-a3b8hyyr	793	4	the	the	DT
cord-006860-a3b8hyyr	793	5	prevalence	prevalence	NN
cord-006860-a3b8hyyr	793	6	of	of	IN
cord-006860-a3b8hyyr	793	7	the	the	DT
cord-006860-a3b8hyyr	793	8	Factor	factor	NN
cord-006860-a3b8hyyr	793	9	V	V	NNP
cord-006860-a3b8hyyr	793	10	1691	1691	CD
cord-006860-a3b8hyyr	793	11	G	g	NN
cord-006860-a3b8hyyr	793	12	-	-	HYPH
cord-006860-a3b8hyyr	793	13	A	a	DT
cord-006860-a3b8hyyr	793	14	mutation	mutation	NN
cord-006860-a3b8hyyr	793	15	in	in	IN
cord-006860-a3b8hyyr	793	16	a	a	DT
cord-006860-a3b8hyyr	793	17	population	population	NN
cord-006860-a3b8hyyr	793	18	of	of	IN
cord-006860-a3b8hyyr	793	19	700	700	CD
cord-006860-a3b8hyyr	793	20	probands	proband	NNS
cord-006860-a3b8hyyr	793	21	of	of	IN
cord-006860-a3b8hyyr	793	22	north	north	JJ
cord-006860-a3b8hyyr	793	23	-	-	HYPH
cord-006860-a3b8hyyr	793	24	eastern	eastern	JJ
cord-006860-a3b8hyyr	793	25	part	part	NN
cord-006860-a3b8hyyr	793	26	of	of	IN
cord-006860-a3b8hyyr	793	27	Germany	Germany	NNP
cord-006860-a3b8hyyr	793	28	.	.	.
cord-006860-a3b8hyyr	794	1	The	the	DT
cord-006860-a3b8hyyr	794	2	mutation	mutation	NN
cord-006860-a3b8hyyr	794	3	was	be	VBD
cord-006860-a3b8hyyr	794	4	found	find	VBN
cord-006860-a3b8hyyr	794	5	in	in	IN
cord-006860-a3b8hyyr	794	6	7	7	CD
cord-006860-a3b8hyyr	794	7	%	%	NN
cord-006860-a3b8hyyr	794	8	.	.	.
cord-006860-a3b8hyyr	795	1	(	(	-LRB-
cord-006860-a3b8hyyr	795	2	Heterozygoty	Heterozygoty	NNP
cord-006860-a3b8hyyr	795	3	were	be	VBD
cord-006860-a3b8hyyr	795	4	found	find	VBN
cord-006860-a3b8hyyr	795	5	in	in	IN
cord-006860-a3b8hyyr	795	6	48	48	CD
cord-006860-a3b8hyyr	795	7	subjects	subject	NNS
cord-006860-a3b8hyyr	795	8	1	1	CD
cord-006860-a3b8hyyr	795	9	person	person	NN
cord-006860-a3b8hyyr	795	10	was	be	VBD
cord-006860-a3b8hyyr	795	11	homozygous	homozygous	JJ
cord-006860-a3b8hyyr	795	12	.	.	.
cord-006860-a3b8hyyr	795	13	)	)	-RRB-
cord-006860-a3b8hyyr	796	1	The	the	DT
cord-006860-a3b8hyyr	796	2	results	result	NNS
cord-006860-a3b8hyyr	796	3	are	be	VBP
cord-006860-a3b8hyyr	796	4	compared	compare	VBN
cord-006860-a3b8hyyr	796	5	with	with	IN
cord-006860-a3b8hyyr	796	6	our	-PRON-	PRP$
cord-006860-a3b8hyyr	796	7	studies	study	NNS
cord-006860-a3b8hyyr	796	8	of	of	IN
cord-006860-a3b8hyyr	796	9	populations	population	NNS
cord-006860-a3b8hyyr	796	10	from	from	IN
cord-006860-a3b8hyyr	796	11	Argentine	Argentine	NNP
cord-006860-a3b8hyyr	796	12	and	and	CC
cord-006860-a3b8hyyr	796	13	Poland	Poland	NNP
cord-006860-a3b8hyyr	796	14	.	.	.
cord-006860-a3b8hyyr	797	1	Me	-PRON-	PRP
cord-006860-a3b8hyyr	797	2	analysed	analyse	VBD
cord-006860-a3b8hyyr	797	3	the	the	DT
cord-006860-a3b8hyyr	797	4	factor	factor	NN
cord-006860-a3b8hyyr	797	5	V	v	NN
cord-006860-a3b8hyyr	797	6	1691	1691	CD
cord-006860-a3b8hyyr	797	7	G	g	NN
cord-006860-a3b8hyyr	797	8	-	-	HYPH
cord-006860-a3b8hyyr	797	9	A	a	DT
cord-006860-a3b8hyyr	797	10	mutation	mutation	NN
cord-006860-a3b8hyyr	797	11	in	in	IN
cord-006860-a3b8hyyr	797	12	71	71	CD
cord-006860-a3b8hyyr	797	13	patients	patient	NNS
cord-006860-a3b8hyyr	797	14	with	with	IN
cord-006860-a3b8hyyr	797	15	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	797	16	from	from	IN
cord-006860-a3b8hyyr	797	17	Germany	Germany	NNP
cord-006860-a3b8hyyr	797	18	and	and	CC
cord-006860-a3b8hyyr	797	19	Hungary	Hungary	NNP
cord-006860-a3b8hyyr	797	20	.	.	.
cord-006860-a3b8hyyr	798	1	This	this	DT
cord-006860-a3b8hyyr	798	2	mutation	mutation	NN
cord-006860-a3b8hyyr	798	3	has	have	VBZ
cord-006860-a3b8hyyr	798	4	been	be	VBN
cord-006860-a3b8hyyr	798	5	found	find	VBN
cord-006860-a3b8hyyr	798	6	in	in	IN
cord-006860-a3b8hyyr	798	7	about	about	RB
cord-006860-a3b8hyyr	798	8	60	60	CD
cord-006860-a3b8hyyr	798	9	%	%	NN
cord-006860-a3b8hyyr	798	10	of	of	IN
cord-006860-a3b8hyyr	798	11	these	these	DT
cord-006860-a3b8hyyr	798	12	patients	patient	NNS
cord-006860-a3b8hyyr	798	13	.	.	.
cord-006860-a3b8hyyr	799	1	In	in	IN
cord-006860-a3b8hyyr	799	2	contrast	contrast	NN
cord-006860-a3b8hyyr	799	3	,	,	,
cord-006860-a3b8hyyr	799	4	the	the	DT
cord-006860-a3b8hyyr	799	5	frequency	frequency	NN
cord-006860-a3b8hyyr	799	6	of	of	IN
cord-006860-a3b8hyyr	799	7	this	this	DT
cord-006860-a3b8hyyr	799	8	mutation	mutation	NN
cord-006860-a3b8hyyr	799	9	was	be	VBD
cord-006860-a3b8hyyr	799	10	strongly	strongly	RB
cord-006860-a3b8hyyr	799	11	reduced	reduce	VBN
cord-006860-a3b8hyyr	799	12	in	in	IN
cord-006860-a3b8hyyr	799	13	a	a	DT
cord-006860-a3b8hyyr	799	14	group	group	NN
cord-006860-a3b8hyyr	799	15	of	of	IN
cord-006860-a3b8hyyr	799	16	47	47	CD
cord-006860-a3b8hyyr	799	17	patients	patient	NNS
cord-006860-a3b8hyyr	799	18	with	with	IN
cord-006860-a3b8hyyr	799	19	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	799	20	and	and	CC
cord-006860-a3b8hyyr	799	21	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	799	22	embolism	embolism	NN
cord-006860-a3b8hyyr	799	23	of	of	IN
cord-006860-a3b8hyyr	799	24	Argentine	Argentine	NNP
cord-006860-a3b8hyyr	799	25	(	(	-LRB-
cord-006860-a3b8hyyr	799	26	3	3	CD
cord-006860-a3b8hyyr	799	27	heterozygotes	heterozygote	NNS
cord-006860-a3b8hyyr	799	28	in	in	IN
cord-006860-a3b8hyyr	799	29	47	47	CD
cord-006860-a3b8hyyr	799	30	patients	patient	NNS
cord-006860-a3b8hyyr	799	31	;	;	:
cord-006860-a3b8hyyr	799	32	6	6	CD
cord-006860-a3b8hyyr	799	33	%	%	NN
cord-006860-a3b8hyyr	799	34	)	)	-RRB-
cord-006860-a3b8hyyr	799	35	.	.	.
cord-006860-a3b8hyyr	800	1	The	the	DT
cord-006860-a3b8hyyr	800	2	results	result	NNS
cord-006860-a3b8hyyr	800	3	of	of	IN
cord-006860-a3b8hyyr	800	4	these	these	DT
cord-006860-a3b8hyyr	800	5	different	different	JJ
cord-006860-a3b8hyyr	800	6	populations	population	NNS
cord-006860-a3b8hyyr	800	7	will	will	MD
cord-006860-a3b8hyyr	800	8	be	be	VB
cord-006860-a3b8hyyr	800	9	described	describe	VBN
cord-006860-a3b8hyyr	800	10	and	and	CC
cord-006860-a3b8hyyr	800	11	discussed	discuss	VBN
cord-006860-a3b8hyyr	800	12	.	.	.
cord-006860-a3b8hyyr	801	1	Past	past	JJ
cord-006860-a3b8hyyr	801	2	medical	medical	JJ
cord-006860-a3b8hyyr	801	3	history	history	NN
cord-006860-a3b8hyyr	801	4	:	:	:
cord-006860-a3b8hyyr	802	1	Venous	venous	JJ
cord-006860-a3b8hyyr	802	2	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	802	3	events	event	NNS
cord-006860-a3b8hyyr	802	4	(	(	-LRB-
cord-006860-a3b8hyyr	802	5	rE	re	NN
cord-006860-a3b8hyyr	802	6	)	)	-RRB-
cord-006860-a3b8hyyr	802	7	at	at	IN
cord-006860-a3b8hyyr	802	8	18	18	CD
cord-006860-a3b8hyyr	802	9	,	,	,
cord-006860-a3b8hyyr	802	10	19	19	CD
cord-006860-a3b8hyyr	802	11	and	and	CC
cord-006860-a3b8hyyr	802	12	2I	2i	CD
cord-006860-a3b8hyyr	802	13	years	year	NNS
cord-006860-a3b8hyyr	802	14	;	;	:
cord-006860-a3b8hyyr	802	15	intermittent	intermittent	JJ
cord-006860-a3b8hyyr	802	16	oral	oral	JJ
cord-006860-a3b8hyyr	802	17	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	802	18	(	(	-LRB-
cord-006860-a3b8hyyr	802	19	OAC	OAC	NNP
cord-006860-a3b8hyyr	802	20	)	)	-RRB-
cord-006860-a3b8hyyr	802	21	without	without	IN
cord-006860-a3b8hyyr	802	22	TE	TE	NNP
cord-006860-a3b8hyyr	802	23	's	's	POS
cord-006860-a3b8hyyr	802	24	.	.	.
cord-006860-a3b8hyyr	803	1	Diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	803	2	of	of	IN
cord-006860-a3b8hyyr	803	3	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	803	4	disorder	disorder	NN
cord-006860-a3b8hyyr	803	5	with	with	IN
cord-006860-a3b8hyyr	803	6	elevated	elevated	JJ
cord-006860-a3b8hyyr	803	7	antinuelear	antinuelear	NN
cord-006860-a3b8hyyr	803	8	-	-	HYPH
cord-006860-a3b8hyyr	803	9	antibody	antibody	NN
cord-006860-a3b8hyyr	803	10	-	-	HYPH
cord-006860-a3b8hyyr	803	11	fiters	fiter	NNS
cord-006860-a3b8hyyr	803	12	and	and	CC
cord-006860-a3b8hyyr	803	13	positive	positive	JJ
cord-006860-a3b8hyyr	803	14	lupus	lupus	NN
cord-006860-a3b8hyyr	803	15	-	-	HYPH
cord-006860-a3b8hyyr	803	16	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	803	17	test	test	NN
cord-006860-a3b8hyyr	803	18	.	.	.
cord-006860-a3b8hyyr	804	1	No	no	DT
cord-006860-a3b8hyyr	804	2	other	other	JJ
cord-006860-a3b8hyyr	804	3	relevant	relevant	JJ
cord-006860-a3b8hyyr	804	4	illnesses	illness	NNS
cord-006860-a3b8hyyr	804	5	;	;	:
cord-006860-a3b8hyyr	804	6	family	family	NN
cord-006860-a3b8hyyr	804	7	history	history	NN
cord-006860-a3b8hyyr	804	8	uneventful	uneventful	JJ
cord-006860-a3b8hyyr	804	9	.	.	.
cord-006860-a3b8hyyr	805	1	Two	two	CD
cord-006860-a3b8hyyr	805	2	weeks	week	NNS
cord-006860-a3b8hyyr	805	3	prior	prior	RB
cord-006860-a3b8hyyr	805	4	to	to	IN
cord-006860-a3b8hyyr	805	5	the	the	DT
cord-006860-a3b8hyyr	805	6	referral	referral	NN
cord-006860-a3b8hyyr	805	7	to	to	IN
cord-006860-a3b8hyyr	805	8	us	-PRON-	PRP
cord-006860-a3b8hyyr	805	9	-acute	-acute	CD
cord-006860-a3b8hyyr	805	10	febrile	febrile	JJ
cord-006860-a3b8hyyr	805	11	illness	illness	NN
cord-006860-a3b8hyyr	805	12	with	with	IN
cord-006860-a3b8hyyr	805	13	nausea	nausea	NN
cord-006860-a3b8hyyr	805	14	,	,	,
cord-006860-a3b8hyyr	805	15	diarrhea	diarrhea	NN
cord-006860-a3b8hyyr	805	16	,	,	,
cord-006860-a3b8hyyr	805	17	abdominal	abdominal	JJ
cord-006860-a3b8hyyr	805	18	pain	pain	NN
cord-006860-a3b8hyyr	805	19	;	;	:
cord-006860-a3b8hyyr	805	20	hospitalisation	hospitalisation	NN
cord-006860-a3b8hyyr	805	21	,	,	,
cord-006860-a3b8hyyr	805	22	treatment	treatment	NN
cord-006860-a3b8hyyr	805	23	with	with	IN
cord-006860-a3b8hyyr	805	24	iv	iv	NNP
cord-006860-a3b8hyyr	805	25	antibiotics	antibiotic	NNS
cord-006860-a3b8hyyr	805	26	and	and	CC
cord-006860-a3b8hyyr	805	27	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	805	28	with	with	IN
cord-006860-a3b8hyyr	805	29	fraetionated	fraetionate	VBN
cord-006860-a3b8hyyr	805	30	heparin	heparin	NN
cord-006860-a3b8hyyr	805	31	;	;	:
cord-006860-a3b8hyyr	805	32	development	development	NN
cord-006860-a3b8hyyr	805	33	of	of	IN
cord-006860-a3b8hyyr	805	34	extensive	extensive	JJ
cord-006860-a3b8hyyr	805	35	deep	deep	JJ
cord-006860-a3b8hyyr	805	36	vein	vein	NN
cord-006860-a3b8hyyr	805	37	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	805	38	(	(	-LRB-
cord-006860-a3b8hyyr	805	39	DVT	DVT	NNP
cord-006860-a3b8hyyr	805	40	)	)	-RRB-
cord-006860-a3b8hyyr	805	41	of	of	IN
cord-006860-a3b8hyyr	805	42	the	the	DT
cord-006860-a3b8hyyr	805	43	right	right	JJ
cord-006860-a3b8hyyr	805	44	leg	leg	NN
cord-006860-a3b8hyyr	805	45	;	;	:
cord-006860-a3b8hyyr	805	46	initiation	initiation	NN
cord-006860-a3b8hyyr	805	47	of	of	IN
cord-006860-a3b8hyyr	805	48	full	full	JJ
cord-006860-a3b8hyyr	805	49	-	-	HYPH
cord-006860-a3b8hyyr	805	50	dose	dose	NN
cord-006860-a3b8hyyr	805	51	unfractionated	unfractionate	VBN
cord-006860-a3b8hyyr	805	52	heparin	heparin	NN
cord-006860-a3b8hyyr	805	53	;	;	:
cord-006860-a3b8hyyr	805	54	decline	decline	NN
cord-006860-a3b8hyyr	805	55	of	of	IN
cord-006860-a3b8hyyr	805	56	platelet	platelet	NN
cord-006860-a3b8hyyr	805	57	count	count	NN
cord-006860-a3b8hyyr	805	58	from	from	IN
cord-006860-a3b8hyyr	805	59	121	121	CD
cord-006860-a3b8hyyr	805	60	to	to	IN
cord-006860-a3b8hyyr	805	61	a	a	DT
cord-006860-a3b8hyyr	805	62	nadir	nadir	NN
cord-006860-a3b8hyyr	805	63	of	of	IN
cord-006860-a3b8hyyr	805	64	21	21	CD
cord-006860-a3b8hyyr	805	65	G	g	NN
cord-006860-a3b8hyyr	805	66	/	/	SYM
cord-006860-a3b8hyyr	805	67	l	l	NN
cord-006860-a3b8hyyr	805	68	;	;	:
cord-006860-a3b8hyyr	805	69	referral	referral	NN
cord-006860-a3b8hyyr	805	70	to	to	IN
cord-006860-a3b8hyyr	805	71	our	-PRON-	PRP$
cord-006860-a3b8hyyr	805	72	department	department	NN
cord-006860-a3b8hyyr	805	73	.	.	.
cord-006860-a3b8hyyr	806	1	On	on	IN
cord-006860-a3b8hyyr	806	2	admission	admission	NN
cord-006860-a3b8hyyr	806	3	an	an	DT
cord-006860-a3b8hyyr	806	4	extensive	extensive	JJ
cord-006860-a3b8hyyr	806	5	coagulation	coagulation	NN
cord-006860-a3b8hyyr	806	6	screen	screen	NN
cord-006860-a3b8hyyr	806	7	yielded	yield	VBD
cord-006860-a3b8hyyr	806	8	the	the	DT
cord-006860-a3b8hyyr	806	9	following	follow	VBG
cord-006860-a3b8hyyr	806	10	results	result	NNS
cord-006860-a3b8hyyr	806	11	(	(	-LRB-
cord-006860-a3b8hyyr	806	12	n	n	NN
cord-006860-a3b8hyyr	806	13	/	/	SYM
cord-006860-a3b8hyyr	806	14	normal	normal	JJ
cord-006860-a3b8hyyr	807	1	,	,	,
cord-006860-a3b8hyyr	807	2	t	t	NN
cord-006860-a3b8hyyr	807	3	/	/	SYM
cord-006860-a3b8hyyr	807	4	elevated	elevate	VBN
cord-006860-a3b8hyyr	807	5	,	,	,
cord-006860-a3b8hyyr	807	6	I	i	NN
cord-006860-a3b8hyyr	807	7	/	/	SYM
cord-006860-a3b8hyyr	807	8	reduced	reduce	VBN
cord-006860-a3b8hyyr	807	9	,	,	,
cord-006860-a3b8hyyr	807	10	+	+	CC
cord-006860-a3b8hyyr	808	1	/positive	/positive	,
cord-006860-a3b8hyyr	808	2	,	,	,
cord-006860-a3b8hyyr	808	3	-/negative	-/negative	JJ
cord-006860-a3b8hyyr	808	4	)	)	-RRB-
cord-006860-a3b8hyyr	808	5	:	:	:
cord-006860-a3b8hyyr	809	1	PT	PT	NNP
cord-006860-a3b8hyyr	809	2	t	t	NNP
cord-006860-a3b8hyyr	809	3	,	,	,
cord-006860-a3b8hyyr	809	4	aPTT	aptt	CC
cord-006860-a3b8hyyr	809	5	t	t	NN
cord-006860-a3b8hyyr	809	6	,	,	,
cord-006860-a3b8hyyr	809	7	Tr	Tr	NNP
cord-006860-a3b8hyyr	809	8	n	n	NNP
cord-006860-a3b8hyyr	809	9	,	,	,
cord-006860-a3b8hyyr	809	10	factor	factor	NN
cord-006860-a3b8hyyr	809	11	II	II	NNP
cord-006860-a3b8hyyr	809	12	,	,	,
cord-006860-a3b8hyyr	809	13	V	v	NN
cord-006860-a3b8hyyr	809	14	,	,	,
cord-006860-a3b8hyyr	809	15	VIII	VIII	NNP
cord-006860-a3b8hyyr	809	16	n	n	NNP
cord-006860-a3b8hyyr	809	17	,	,	,
cord-006860-a3b8hyyr	809	18	factor	factor	NN
cord-006860-a3b8hyyr	809	19	VII	VII	NNP
cord-006860-a3b8hyyr	809	20	,	,	,
cord-006860-a3b8hyyr	809	21	IX	IX	NNP
cord-006860-a3b8hyyr	809	22	,	,	,
cord-006860-a3b8hyyr	809	23	XI	XI	NNP
cord-006860-a3b8hyyr	809	24	,	,	,
cord-006860-a3b8hyyr	809	25	XII	XII	NNP
cord-006860-a3b8hyyr	809	26	/	/	SYM
cord-006860-a3b8hyyr	809	27	,	,	,
cord-006860-a3b8hyyr	809	28	,	,	,
cord-006860-a3b8hyyr	809	29	fibrinogan	fibrinogan	NNP
cord-006860-a3b8hyyr	809	30	t	t	NNP
cord-006860-a3b8hyyr	809	31	,	,	,
cord-006860-a3b8hyyr	809	32	ATIII	ATIII	NNP
cord-006860-a3b8hyyr	809	33	n	n	NNP
cord-006860-a3b8hyyr	809	34	,	,	,
cord-006860-a3b8hyyr	809	35	protein	protein	NN
cord-006860-a3b8hyyr	809	36	C	C	NNP
cord-006860-a3b8hyyr	809	37	,	,	,
cord-006860-a3b8hyyr	809	38	S	S	NNP
cord-006860-a3b8hyyr	809	39	*	*	NFP
cord-006860-a3b8hyyr	809	40	,	,	,
cord-006860-a3b8hyyr	809	41	activated	activate	VBD
cord-006860-a3b8hyyr	809	42	protein	protein	NN
cord-006860-a3b8hyyr	809	43	C	c	NN
cord-006860-a3b8hyyr	809	44	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	809	45	ratio	ratio	NN
cord-006860-a3b8hyyr	809	46	1.92	1.92	CD
cord-006860-a3b8hyyr	809	47	(	(	-LRB-
cord-006860-a3b8hyyr	809	48	$	$	$
cord-006860-a3b8hyyr	809	49	)	)	-RRB-
cord-006860-a3b8hyyr	809	50	,	,	,
cord-006860-a3b8hyyr	809	51	FV	FV	NNP
cord-006860-a3b8hyyr	809	52	-	-	HYPH
cord-006860-a3b8hyyr	809	53	Leidenmutation	Leidenmutation	NNP
cord-006860-a3b8hyyr	809	54	PCR	PCR	NNP
cord-006860-a3b8hyyr	809	55	-	-	HYPH
cord-006860-a3b8hyyr	809	56	,	,	,
cord-006860-a3b8hyyr	809	57	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	809	58	system	system	NN
cord-006860-a3b8hyyr	809	59	n	n	NNP
cord-006860-a3b8hyyr	809	60	,	,	,
cord-006860-a3b8hyyr	809	61	TAT	TAT	NNP
cord-006860-a3b8hyyr	809	62	t	t	NNP
cord-006860-a3b8hyyr	809	63	,	,	,
cord-006860-a3b8hyyr	809	64	Ft÷2	Ft÷2	NNP
cord-006860-a3b8hyyr	809	65	t	t	NNP
cord-006860-a3b8hyyr	809	66	,	,	,
cord-006860-a3b8hyyr	809	67	lupus	lupus	NN
cord-006860-a3b8hyyr	809	68	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	809	69	+	+	CC
cord-006860-a3b8hyyr	809	70	,	,	,
cord-006860-a3b8hyyr	809	71	heparin	heparin	NN
cord-006860-a3b8hyyr	809	72	induced	induce	VBN
cord-006860-a3b8hyyr	809	73	platelet	platelet	NN
cord-006860-a3b8hyyr	809	74	antibodies	antibody	NNS
cord-006860-a3b8hyyr	809	75	+	+	CC
cord-006860-a3b8hyyr	809	76	;	;	:
cord-006860-a3b8hyyr	809	77	no	no	DT
cord-006860-a3b8hyyr	809	78	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	809	79	of	of	IN
cord-006860-a3b8hyyr	809	80	a	a	DT
cord-006860-a3b8hyyr	809	81	specific	specific	JJ
cord-006860-a3b8hyyr	809	82	autoimmuna	autoimmuna	NN
cord-006860-a3b8hyyr	809	83	disorder	disorder	NN
cord-006860-a3b8hyyr	809	84	could	could	MD
cord-006860-a3b8hyyr	809	85	be	be	VB
cord-006860-a3b8hyyr	809	86	made	make	VBN
cord-006860-a3b8hyyr	809	87	.	.	.
cord-006860-a3b8hyyr	810	1	An	an	DT
cord-006860-a3b8hyyr	810	2	immunosuppressive	immunosuppressive	JJ
cord-006860-a3b8hyyr	810	3	therapy	therapy	NN
cord-006860-a3b8hyyr	810	4	with	with	IN
cord-006860-a3b8hyyr	810	5	corticosteroids	corticosteroid	NNS
cord-006860-a3b8hyyr	810	6	and	and	CC
cord-006860-a3b8hyyr	810	7	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	810	8	with	with	IN
cord-006860-a3b8hyyr	810	9	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	810	10	hirudin	hirudin	NN
cord-006860-a3b8hyyr	810	11	were	be	VBD
cord-006860-a3b8hyyr	810	12	init'~at~	init'~at~	JJ
cord-006860-a3b8hyyr	810	13	;	;	.
cord-006860-a3b8hyyr	811	1	no	no	DT
cord-006860-a3b8hyyr	811	2	p	p	NN
cord-006860-a3b8hyyr	811	3	~	~	CD
cord-006860-a3b8hyyr	811	4	ogr	ogr	NN
cord-006860-a3b8hyyr	811	5	~	~	CD
cord-006860-a3b8hyyr	811	6	zsion	zsion	NN
cord-006860-a3b8hyyr	811	7	of	of	IN
cord-006860-a3b8hyyr	811	8	the	the	DT
cord-006860-a3b8hyyr	811	9	DVT	DVT	NNP
cord-006860-a3b8hyyr	811	10	oeeured	oeeure	VBN
cord-006860-a3b8hyyr	811	11	and	and	CC
cord-006860-a3b8hyyr	811	12	normalisation	normalisation	NN
cord-006860-a3b8hyyr	811	13	of	of	IN
cord-006860-a3b8hyyr	811	14	the	the	DT
cord-006860-a3b8hyyr	811	15	platelet	platelet	NN
cord-006860-a3b8hyyr	811	16	count	count	NN
cord-006860-a3b8hyyr	811	17	was	be	VBD
cord-006860-a3b8hyyr	811	18	observed	observe	VBN
cord-006860-a3b8hyyr	811	19	.	.	.
cord-006860-a3b8hyyr	812	1	During	during	IN
cord-006860-a3b8hyyr	812	2	follow	follow	NN
cord-006860-a3b8hyyr	812	3	-	-	HYPH
cord-006860-a3b8hyyr	812	4	up	up	NN
cord-006860-a3b8hyyr	812	5	under	under	IN
cord-006860-a3b8hyyr	812	6	OAC	OAC	NNP
cord-006860-a3b8hyyr	812	7	)	)	-RRB-
cord-006860-a3b8hyyr	812	8	and	and	CC
cord-006860-a3b8hyyr	812	9	low	low	JJ
cord-006860-a3b8hyyr	812	10	-	-	HYPH
cord-006860-a3b8hyyr	812	11	dose	dose	NN
cord-006860-a3b8hyyr	812	12	corticosteroids	corticosteroid	NNS
cord-006860-a3b8hyyr	812	13	,	,	,
cord-006860-a3b8hyyr	812	14	the	the	DT
cord-006860-a3b8hyyr	812	15	patient	patient	NN
cord-006860-a3b8hyyr	812	16	was	be	VBD
cord-006860-a3b8hyyr	812	17	well	well	RB
cord-006860-a3b8hyyr	812	18	,	,	,
cord-006860-a3b8hyyr	812	19	the	the	DT
cord-006860-a3b8hyyr	812	20	pathologic	pathologic	JJ
cord-006860-a3b8hyyr	812	21	coagulat;.on	coagulat;.on	NN
cord-006860-a3b8hyyr	812	22	results	result	NNS
cord-006860-a3b8hyyr	812	23	,	,	,
cord-006860-a3b8hyyr	812	24	including	include	VBG
cord-006860-a3b8hyyr	812	25	lupusanticoagulant	lupusanticoagulant	NNP
cord-006860-a3b8hyyr	812	26	and	and	CC
cord-006860-a3b8hyyr	812	27	activated	activate	VBD
cord-006860-a3b8hyyr	812	28	protein	protein	NN
cord-006860-a3b8hyyr	812	29	C	c	NN
cord-006860-a3b8hyyr	812	30	resistance	resistance	NN
cord-006860-a3b8hyyr	812	31	,	,	,
cord-006860-a3b8hyyr	812	32	have	have	VBP
cord-006860-a3b8hyyr	812	33	returned	return	VBN
cord-006860-a3b8hyyr	812	34	to	to	IN
cord-006860-a3b8hyyr	812	35	normal	normal	JJ
cord-006860-a3b8hyyr	812	36	;	;	:
cord-006860-a3b8hyyr	812	37	no	no	DT
cord-006860-a3b8hyyr	812	38	further	further	JJ
cord-006860-a3b8hyyr	812	39	TE	TE	NNP
cord-006860-a3b8hyyr	812	40	's	's	POS
cord-006860-a3b8hyyr	812	41	have	have	VBP
cord-006860-a3b8hyyr	812	42	been	be	VBN
cord-006860-a3b8hyyr	812	43	observed	observe	VBN
cord-006860-a3b8hyyr	812	44	.	.	.
cord-006860-a3b8hyyr	813	1	In	in	IN
cord-006860-a3b8hyyr	813	2	summary	summary	NN
cord-006860-a3b8hyyr	813	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	813	4	present	present	VBP
cord-006860-a3b8hyyr	813	5	a	a	DT
cord-006860-a3b8hyyr	813	6	case	case	NN
cord-006860-a3b8hyyr	813	7	of	of	IN
cord-006860-a3b8hyyr	813	8	a	a	DT
cord-006860-a3b8hyyr	813	9	complex	complex	JJ
cord-006860-a3b8hyyr	813	10	coagulation	coagulation	NN
cord-006860-a3b8hyyr	813	11	disorder	disorder	NN
cord-006860-a3b8hyyr	813	12	as	as	IN
cord-006860-a3b8hyyr	813	13	part	part	NN
cord-006860-a3b8hyyr	813	14	of	of	IN
cord-006860-a3b8hyyr	813	15	an	an	DT
cord-006860-a3b8hyyr	813	16	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	813	17	process	process	NN
cord-006860-a3b8hyyr	813	18	,	,	,
cord-006860-a3b8hyyr	813	19	resulting	result	VBG
cord-006860-a3b8hyyr	813	20	in	in	IN
cord-006860-a3b8hyyr	813	21	a	a	DT
cord-006860-a3b8hyyr	813	22	clinically	clinically	RB
cord-006860-a3b8hyyr	813	23	manifest	manifest	JJ
cord-006860-a3b8hyyr	813	24	prothrombotie	prothrombotie	NN
cord-006860-a3b8hyyr	813	25	dysbalance	dysbalance	NN
cord-006860-a3b8hyyr	813	26	including	include	VBG
cord-006860-a3b8hyyr	813	27	lupus	lupus	NNP
cord-006860-a3b8hyyr	813	28	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	813	29	,	,	,
cord-006860-a3b8hyyr	813	30	acquired	acquire	VBD
cord-006860-a3b8hyyr	813	31	resistance	resistance	NN
cord-006860-a3b8hyyr	813	32	against	against	IN
cord-006860-a3b8hyyr	813	33	activated	activate	VBN
cord-006860-a3b8hyyr	813	34	protein	protein	NN
cord-006860-a3b8hyyr	813	35	C	c	NN
cord-006860-a3b8hyyr	813	36	and	and	CC
cord-006860-a3b8hyyr	813	37	heparin	heparin	NNP
cord-006860-a3b8hyyr	814	1	induced	induce	VBN
cord-006860-a3b8hyyr	814	2	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	814	3	(	(	-LRB-
cord-006860-a3b8hyyr	814	4	type	type	NN
cord-006860-a3b8hyyr	814	5	II	II	NNP
cord-006860-a3b8hyyr	814	6	)	)	-RRB-
cord-006860-a3b8hyyr	814	7	,	,	,
cord-006860-a3b8hyyr	814	8	entering	enter	VBG
cord-006860-a3b8hyyr	814	9	complete	complete	JJ
cord-006860-a3b8hyyr	814	10	remission	remission	NN
cord-006860-a3b8hyyr	814	11	under	under	IN
cord-006860-a3b8hyyr	814	12	combined	combine	VBN
cord-006860-a3b8hyyr	814	13	immunosuppressive	immunosuppressive	JJ
cord-006860-a3b8hyyr	814	14	and	and	CC
cord-006860-a3b8hyyr	814	15	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	814	16	therapy	therapy	NN
cord-006860-a3b8hyyr	814	17	.	.	.
cord-006860-a3b8hyyr	815	1	In	in	IN
cord-006860-a3b8hyyr	815	2	the	the	DT
cord-006860-a3b8hyyr	815	3	last	last	JJ
cord-006860-a3b8hyyr	815	4	30	30	CD
cord-006860-a3b8hyyr	815	5	years	year	NNS
cord-006860-a3b8hyyr	815	6	,	,	,
cord-006860-a3b8hyyr	815	7	a	a	DT
cord-006860-a3b8hyyr	815	8	vast	vast	JJ
cord-006860-a3b8hyyr	815	9	number	number	NN
cord-006860-a3b8hyyr	815	10	of	of	IN
cord-006860-a3b8hyyr	815	11	simplified	simplified	JJ
cord-006860-a3b8hyyr	815	12	analytical	analytical	JJ
cord-006860-a3b8hyyr	815	13	procedures	procedure	NNS
cord-006860-a3b8hyyr	815	14	have	have	VBP
cord-006860-a3b8hyyr	815	15	been	be	VBN
cord-006860-a3b8hyyr	815	16	developed	develop	VBN
cord-006860-a3b8hyyr	815	17	for	for	IN
cord-006860-a3b8hyyr	815	18	the	the	DT
cord-006860-a3b8hyyr	815	19	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	815	20	of	of	IN
cord-006860-a3b8hyyr	815	21	haemostatic	haemostatic	JJ
cord-006860-a3b8hyyr	815	22	disorders	disorder	NNS
cord-006860-a3b8hyyr	815	23	.	.	.
cord-006860-a3b8hyyr	816	1	Today	today	NN
cord-006860-a3b8hyyr	816	2	the	the	DT
cord-006860-a3b8hyyr	816	3	detection	detection	NN
cord-006860-a3b8hyyr	816	4	method	method	NN
cord-006860-a3b8hyyr	816	5	have	have	VBP
cord-006860-a3b8hyyr	816	6	evolved	evolve	VBN
cord-006860-a3b8hyyr	816	7	from	from	IN
cord-006860-a3b8hyyr	816	8	the	the	DT
cord-006860-a3b8hyyr	816	9	mechanical	mechanical	JJ
cord-006860-a3b8hyyr	816	10	hooking	hooking	NN
cord-006860-a3b8hyyr	816	11	method	method	NN
cord-006860-a3b8hyyr	816	12	or	or	CC
cord-006860-a3b8hyyr	816	13	ball	ball	NN
cord-006860-a3b8hyyr	816	14	coagulometry	coagulometry	NN
cord-006860-a3b8hyyr	816	15	to	to	IN
cord-006860-a3b8hyyr	816	16	optical	optical	JJ
cord-006860-a3b8hyyr	816	17	systems	system	NNS
cord-006860-a3b8hyyr	816	18	,	,	,
cord-006860-a3b8hyyr	816	19	which	which	WDT
cord-006860-a3b8hyyr	816	20	additionally	additionally	RB
cord-006860-a3b8hyyr	816	21	can	can	MD
cord-006860-a3b8hyyr	816	22	utilise	utilise	VB
cord-006860-a3b8hyyr	816	23	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	816	24	substrates	substrate	NNS
cord-006860-a3b8hyyr	816	25	or	or	CC
cord-006860-a3b8hyyr	816	26	immunological	immunological	JJ
cord-006860-a3b8hyyr	816	27	methods	method	NNS
cord-006860-a3b8hyyr	816	28	.	.	.
cord-006860-a3b8hyyr	817	1	In	in	IN
cord-006860-a3b8hyyr	817	2	these	these	DT
cord-006860-a3b8hyyr	817	3	systems	system	NNS
cord-006860-a3b8hyyr	817	4	the	the	DT
cord-006860-a3b8hyyr	817	5	clotting	clotting	NN
cord-006860-a3b8hyyr	817	6	time	time	NN
cord-006860-a3b8hyyr	817	7	is	be	VBZ
cord-006860-a3b8hyyr	817	8	derived	derive	VBN
cord-006860-a3b8hyyr	817	9	from	from	IN
cord-006860-a3b8hyyr	817	10	algorithms	algorithm	NNS
cord-006860-a3b8hyyr	817	11	(	(	-LRB-
cord-006860-a3b8hyyr	817	12	e.g.	e.g.	RB
cord-006860-a3b8hyyr	817	13	threshold	threshold	NN
cord-006860-a3b8hyyr	817	14	or	or	CC
cord-006860-a3b8hyyr	817	15	maximum	maximum	NN
cord-006860-a3b8hyyr	817	16	of	of	IN
cord-006860-a3b8hyyr	817	17	the	the	DT
cord-006860-a3b8hyyr	817	18	first	first	JJ
cord-006860-a3b8hyyr	817	19	or	or	CC
cord-006860-a3b8hyyr	817	20	second	second	JJ
cord-006860-a3b8hyyr	817	21	integral	integral	NN
cord-006860-a3b8hyyr	817	22	)	)	-RRB-
cord-006860-a3b8hyyr	817	23	.	.	.
cord-006860-a3b8hyyr	818	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	818	2	studied	study	VBD
cord-006860-a3b8hyyr	818	3	50	50	CD
cord-006860-a3b8hyyr	818	4	healthy	healthy	JJ
cord-006860-a3b8hyyr	818	5	subjects	subject	NNS
cord-006860-a3b8hyyr	818	6	,	,	,
cord-006860-a3b8hyyr	818	7	aged	age	VBN
cord-006860-a3b8hyyr	818	8	21	21	CD
cord-006860-a3b8hyyr	818	9	to	to	TO
cord-006860-a3b8hyyr	818	10	65	65	CD
cord-006860-a3b8hyyr	818	11	years	year	NNS
cord-006860-a3b8hyyr	818	12	and	and	CC
cord-006860-a3b8hyyr	818	13	118	118	CD
cord-006860-a3b8hyyr	818	14	patients	patient	NNS
cord-006860-a3b8hyyr	818	15	,	,	,
cord-006860-a3b8hyyr	818	16	aged	age	VBN
cord-006860-a3b8hyyr	818	17	9	9	CD
cord-006860-a3b8hyyr	818	18	to	to	TO
cord-006860-a3b8hyyr	818	19	93	93	CD
cord-006860-a3b8hyyr	818	20	years	year	NNS
cord-006860-a3b8hyyr	818	21	using	use	VBG
cord-006860-a3b8hyyr	818	22	a	a	DT
cord-006860-a3b8hyyr	818	23	new	new	JJ
cord-006860-a3b8hyyr	818	24	aPTT	aptt	NN
cord-006860-a3b8hyyr	818	25	reagent	reagent	NN
cord-006860-a3b8hyyr	818	26	(	(	-LRB-
cord-006860-a3b8hyyr	818	27	Pathromtin	Pathromtin	NNP
cord-006860-a3b8hyyr	818	28	$	$	$
cord-006860-a3b8hyyr	818	29	L	L	NNP
cord-006860-a3b8hyyr	818	30	)	)	-RRB-
cord-006860-a3b8hyyr	818	31	.	.	.
cord-006860-a3b8hyyr	819	1	The	the	DT
cord-006860-a3b8hyyr	819	2	results	result	NNS
cord-006860-a3b8hyyr	819	3	were	be	VBD
cord-006860-a3b8hyyr	819	4	compared	compare	VBN
cord-006860-a3b8hyyr	819	5	with	with	IN
cord-006860-a3b8hyyr	819	6	those	those	DT
cord-006860-a3b8hyyr	819	7	obtained	obtain	VBN
cord-006860-a3b8hyyr	819	8	with	with	IN
cord-006860-a3b8hyyr	819	9	a	a	DT
cord-006860-a3b8hyyr	819	10	routinely	routinely	RB
cord-006860-a3b8hyyr	819	11	used	use	VBN
cord-006860-a3b8hyyr	819	12	reagent	reagent	NN
cord-006860-a3b8hyyr	819	13	(	(	-LRB-
cord-006860-a3b8hyyr	819	14	Pathromtin	Pathromtin	NNP
cord-006860-a3b8hyyr	819	15	)	)	-RRB-
cord-006860-a3b8hyyr	819	16	.	.	.
cord-006860-a3b8hyyr	820	1	The	the	DT
cord-006860-a3b8hyyr	820	2	reference	reference	NN
cord-006860-a3b8hyyr	820	3	range	range	NN
cord-006860-a3b8hyyr	820	4	,	,	,
cord-006860-a3b8hyyr	820	5	factor-	factor-	XX
cord-006860-a3b8hyyr	820	6	,	,	,
cord-006860-a3b8hyyr	820	7	heparin	heparin	NN
cord-006860-a3b8hyyr	820	8	-	-	:
cord-006860-a3b8hyyr	820	9	and	and	CC
cord-006860-a3b8hyyr	820	10	Lupus	Lupus	NNP
cord-006860-a3b8hyyr	820	11	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	820	12	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	820	13	were	be	VBD
cord-006860-a3b8hyyr	820	14	determined	determine	VBN
cord-006860-a3b8hyyr	820	15	.	.	.
cord-006860-a3b8hyyr	821	1	Analysis	analysis	NN
cord-006860-a3b8hyyr	821	2	was	be	VBD
cord-006860-a3b8hyyr	821	3	performed	perform	VBN
cord-006860-a3b8hyyr	821	4	using	use	VBG
cord-006860-a3b8hyyr	821	5	the	the	DT
cord-006860-a3b8hyyr	821	6	Behring	Behring	NNP
cord-006860-a3b8hyyr	821	7	Fibrintimer	Fibrintimer	NNP
cord-006860-a3b8hyyr	821	8	A	A	NNP
cord-006860-a3b8hyyr	821	9	(	(	-LRB-
cord-006860-a3b8hyyr	821	10	BFA	BFA	NNP
cord-006860-a3b8hyyr	821	11	)	)	-RRB-
cord-006860-a3b8hyyr	821	12	with	with	IN
cord-006860-a3b8hyyr	821	13	optomechanical	optomechanical	JJ
cord-006860-a3b8hyyr	821	14	clot	clot	NN
cord-006860-a3b8hyyr	821	15	detection	detection	NN
cord-006860-a3b8hyyr	821	16	,	,	,
cord-006860-a3b8hyyr	821	17	the	the	DT
cord-006860-a3b8hyyr	821	18	Behring	Behring	NNP
cord-006860-a3b8hyyr	821	19	Coagulation	Coagulation	NNP
cord-006860-a3b8hyyr	821	20	Timer	Timer	NNP
cord-006860-a3b8hyyr	821	21	(	(	-LRB-
cord-006860-a3b8hyyr	821	22	BCT	BCT	NNP
cord-006860-a3b8hyyr	821	23	)	)	-RRB-
cord-006860-a3b8hyyr	821	24	with	with	IN
cord-006860-a3b8hyyr	821	25	op-"dcal	op-"dcal	NNP
cord-006860-a3b8hyyr	821	26	clot	clot	NN
cord-006860-a3b8hyyr	821	27	detection	detection	NN
cord-006860-a3b8hyyr	821	28	by	by	IN
cord-006860-a3b8hyyr	821	29	threshold	threshold	NN
cord-006860-a3b8hyyr	821	30	and	and	CC
cord-006860-a3b8hyyr	821	31	the	the	DT
cord-006860-a3b8hyyr	821	32	DW	DW	NNP
cord-006860-a3b8hyyr	821	33	test	test	NN
cord-006860-a3b8hyyr	821	34	and	and	CC
cord-006860-a3b8hyyr	822	1	DW	DW	NNP
cord-006860-a3b8hyyr	822	2	confirm	confirm	VBP
cord-006860-a3b8hyyr	822	3	for	for	IN
cord-006860-a3b8hyyr	822	4	Lupus	Lupus	NNP
cord-006860-a3b8hyyr	822	5	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	822	6	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	822	7	.	.	.
cord-006860-a3b8hyyr	823	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	823	2	results	result	NNS
cord-006860-a3b8hyyr	823	3	showed	show	VBD
cord-006860-a3b8hyyr	823	4	that	that	IN
cord-006860-a3b8hyyr	823	5	the	the	DT
cord-006860-a3b8hyyr	823	6	new	new	JJ
cord-006860-a3b8hyyr	823	7	Pathromtin	Pathromtin	NNP
cord-006860-a3b8hyyr	823	8	SL	SL	NNP
cord-006860-a3b8hyyr	823	9	reagent	reagent	NN
cord-006860-a3b8hyyr	823	10	met	meet	VBD
cord-006860-a3b8hyyr	823	11	the	the	DT
cord-006860-a3b8hyyr	823	12	demands	demand	NNS
cord-006860-a3b8hyyr	823	13	for	for	IN
cord-006860-a3b8hyyr	823	14	a	a	DT
cord-006860-a3b8hyyr	823	15	higher	high	JJR
cord-006860-a3b8hyyr	823	16	factor	factor	NN
cord-006860-a3b8hyyr	823	17	and	and	CC
cord-006860-a3b8hyyr	823	18	Lupus	Lupus	NNP
cord-006860-a3b8hyyr	823	19	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	823	20	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	823	21	.	.	.
cord-006860-a3b8hyyr	824	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	824	2	is	be	VBZ
cord-006860-a3b8hyyr	824	3	highly	highly	RB
cord-006860-a3b8hyyr	824	4	suitable	suitable	JJ
cord-006860-a3b8hyyr	824	5	for	for	IN
cord-006860-a3b8hyyr	824	6	monitoring	monitor	VBG
cord-006860-a3b8hyyr	824	7	heparin	heparin	NN
cord-006860-a3b8hyyr	824	8	therapy	therapy	NN
cord-006860-a3b8hyyr	824	9	and	and	CC
cord-006860-a3b8hyyr	824	10	gave	give	VBD
cord-006860-a3b8hyyr	824	11	comparable	comparable	JJ
cord-006860-a3b8hyyr	824	12	results	result	NNS
cord-006860-a3b8hyyr	824	13	with	with	IN
cord-006860-a3b8hyyr	824	14	the	the	DT
cord-006860-a3b8hyyr	824	15	optical	optical	JJ
cord-006860-a3b8hyyr	824	16	and	and	CC
cord-006860-a3b8hyyr	824	17	the	the	DT
cord-006860-a3b8hyyr	824	18	optomechanical	optomechanical	JJ
cord-006860-a3b8hyyr	824	19	analyser	analyser	NN
cord-006860-a3b8hyyr	824	20	systems	system	NNS
cord-006860-a3b8hyyr	824	21	,	,	,
cord-006860-a3b8hyyr	824	22	hence	hence	RB
cord-006860-a3b8hyyr	824	23	reagent	reagent	JJ
cord-006860-a3b8hyyr	824	24	c	c	NN
cord-006860-a3b8hyyr	825	1	~n	~n	NNP
cord-006860-a3b8hyyr	825	2	be	be	VB
cord-006860-a3b8hyyr	825	3	used	use	VBN
cord-006860-a3b8hyyr	825	4	for	for	IN
cord-006860-a3b8hyyr	825	5	both	both	DT
cord-006860-a3b8hyyr	825	6	systems	system	NNS
cord-006860-a3b8hyyr	825	7	.	.	.
cord-006860-a3b8hyyr	826	1	Restenosis	Restenosis	NNP
cord-006860-a3b8hyyr	827	1	following	follow	VBG
cord-006860-a3b8hyyr	827	2	percutaneous	percutaneous	JJ
cord-006860-a3b8hyyr	827	3	transluminal	transluminal	NNP
cord-006860-a3b8hyyr	827	4	angioplasty	angioplasty	NN
cord-006860-a3b8hyyr	827	5	(	(	-LRB-
cord-006860-a3b8hyyr	827	6	PTA	PTA	NNP
cord-006860-a3b8hyyr	827	7	)	)	-RRB-
cord-006860-a3b8hyyr	827	8	continous	continous	JJ
cord-006860-a3b8hyyr	827	9	to	to	TO
cord-006860-a3b8hyyr	827	10	be	be	VB
cord-006860-a3b8hyyr	827	11	a	a	DT
cord-006860-a3b8hyyr	827	12	major	major	JJ
cord-006860-a3b8hyyr	827	13	clinical	clinical	JJ
cord-006860-a3b8hyyr	827	14	problem	problem	NN
cord-006860-a3b8hyyr	827	15	.	.	.
cord-006860-a3b8hyyr	828	1	Neoinfimal	neoinfimal	JJ
cord-006860-a3b8hyyr	828	2	hyperplasia	hyperplasia	NN
cord-006860-a3b8hyyr	828	3	,	,	,
cord-006860-a3b8hyyr	828	4	being	be	VBG
cord-006860-a3b8hyyr	828	5	the	the	DT
cord-006860-a3b8hyyr	828	6	major	major	JJ
cord-006860-a3b8hyyr	828	7	undedying	undedying	NN
cord-006860-a3b8hyyr	828	8	cause	cause	NN
cord-006860-a3b8hyyr	828	9	,	,	,
cord-006860-a3b8hyyr	828	10	can	can	MD
cord-006860-a3b8hyyr	828	11	not	not	RB
cord-006860-a3b8hyyr	828	12	be	be	VB
cord-006860-a3b8hyyr	828	13	sufficiently	sufficiently	RB
cord-006860-a3b8hyyr	828	14	avoided	avoid	VBN
cord-006860-a3b8hyyr	828	15	.	.	.
cord-006860-a3b8hyyr	829	1	Vadous	vadous	JJ
cord-006860-a3b8hyyr	829	2	plasmatic	plasmatic	JJ
cord-006860-a3b8hyyr	829	3	coagulation	coagulation	NN
cord-006860-a3b8hyyr	829	4	and	and	CC
cord-006860-a3b8hyyr	829	5	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	829	6	factors	factor	NNS
cord-006860-a3b8hyyr	829	7	,	,	,
cord-006860-a3b8hyyr	829	8	have	have	VBP
cord-006860-a3b8hyyr	829	9	been	be	VBN
cord-006860-a3b8hyyr	829	10	associated	associate	VBN
cord-006860-a3b8hyyr	829	11	with	with	IN
cord-006860-a3b8hyyr	829	12	artedal	artedal	NNP
cord-006860-a3b8hyyr	829	13	restenosis	restenosis	NNP
cord-006860-a3b8hyyr	829	14	.	.	.
cord-006860-a3b8hyyr	830	1	Anticardiolipin	Anticardiolipin	NNP
cord-006860-a3b8hyyr	830	2	antibodies	antibody	NNS
cord-006860-a3b8hyyr	830	3	(	(	-LRB-
cord-006860-a3b8hyyr	830	4	aCt	aCt	NNP
cord-006860-a3b8hyyr	830	5	_	_	NN
cord-006860-a3b8hyyr	830	6	)	)	-RRB-
cord-006860-a3b8hyyr	830	7	have	have	VBP
cord-006860-a3b8hyyr	830	8	been	be	VBN
cord-006860-a3b8hyyr	830	9	established	establish	VBN
cord-006860-a3b8hyyr	830	10	as	as	IN
cord-006860-a3b8hyyr	830	11	dsk	dsk	NNP
cord-006860-a3b8hyyr	830	12	factors	factor	NNS
cord-006860-a3b8hyyr	830	13	for	for	IN
cord-006860-a3b8hyyr	830	14	venous	venous	JJ
cord-006860-a3b8hyyr	830	15	or	or	CC
cord-006860-a3b8hyyr	830	16	arterial	arterial	JJ
cord-006860-a3b8hyyr	830	17	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	830	18	.	.	.
cord-006860-a3b8hyyr	831	1	Methods	method	NNS
cord-006860-a3b8hyyr	831	2	:	:	:
cord-006860-a3b8hyyr	832	1	In	in	IN
cord-006860-a3b8hyyr	832	2	a	a	DT
cord-006860-a3b8hyyr	832	3	cohort	cohort	NN
cord-006860-a3b8hyyr	832	4	of	of	IN
cord-006860-a3b8hyyr	832	5	75	75	CD
cord-006860-a3b8hyyr	832	6	patients	patient	NNS
cord-006860-a3b8hyyr	832	7	(	(	-LRB-
cord-006860-a3b8hyyr	832	8	53	53	CD
cord-006860-a3b8hyyr	832	9	men	man	NNS
cord-006860-a3b8hyyr	832	10	and	and	CC
cord-006860-a3b8hyyr	832	11	22	22	CD
cord-006860-a3b8hyyr	832	12	women	woman	NNS
cord-006860-a3b8hyyr	832	13	,	,	,
cord-006860-a3b8hyyr	832	14	age	age	NN
cord-006860-a3b8hyyr	832	15	68±13	68±13	NNP
cord-006860-a3b8hyyr	832	16	years	year	NNS
cord-006860-a3b8hyyr	832	17	)	)	-RRB-
cord-006860-a3b8hyyr	832	18	undergoing	undergo	VBG
cord-006860-a3b8hyyr	832	19	PTA	PTA	NNP
cord-006860-a3b8hyyr	832	20	of	of	IN
cord-006860-a3b8hyyr	832	21	a	a	DT
cord-006860-a3b8hyyr	832	22	peripheral	peripheral	JJ
cord-006860-a3b8hyyr	832	23	artery	artery	NN
cord-006860-a3b8hyyr	832	24	we	-PRON-	PRP
cord-006860-a3b8hyyr	832	25	prospectively	prospectively	RB
cord-006860-a3b8hyyr	832	26	evaluated	evaluate	VBD
cord-006860-a3b8hyyr	832	27	whether	whether	IN
cord-006860-a3b8hyyr	832	28	aCL	aCL	NNP
cord-006860-a3b8hyyr	832	29	could	could	MD
cord-006860-a3b8hyyr	832	30	influence	influence	VB
cord-006860-a3b8hyyr	832	31	6	6	CD
cord-006860-a3b8hyyr	832	32	months	month	NNS
cord-006860-a3b8hyyr	832	33	restenosis	restenosis	NN
cord-006860-a3b8hyyr	832	34	rate	rate	NN
cord-006860-a3b8hyyr	832	35	.	.	.
cord-006860-a3b8hyyr	833	1	Patients	patient	NNS
cord-006860-a3b8hyyr	833	2	were	be	VBD
cord-006860-a3b8hyyr	833	3	clinically	clinically	RB
cord-006860-a3b8hyyr	833	4	examined	examine	VBN
cord-006860-a3b8hyyr	833	5	before	before	RB
cord-006860-a3b8hyyr	833	6	,	,	,
cord-006860-a3b8hyyr	833	7	3	3	CD
cord-006860-a3b8hyyr	833	8	and	and	CC
cord-006860-a3b8hyyr	833	9	6	6	CD
cord-006860-a3b8hyyr	833	10	months	month	NNS
cord-006860-a3b8hyyr	833	11	after	after	IN
cord-006860-a3b8hyyr	833	12	PTA	PTA	NNP
cord-006860-a3b8hyyr	833	13	.	.	.
cord-006860-a3b8hyyr	834	1	Noninvasive	noninvasive	JJ
cord-006860-a3b8hyyr	834	2	grading	grading	NN
cord-006860-a3b8hyyr	834	3	of	of	IN
cord-006860-a3b8hyyr	834	4	artedal	artedal	NNP
cord-006860-a3b8hyyr	834	5	stenosis	stenosis	NN
cord-006860-a3b8hyyr	834	6	was	be	VBD
cord-006860-a3b8hyyr	834	7	done	do	VBN
cord-006860-a3b8hyyr	834	8	by	by	IN
cord-006860-a3b8hyyr	834	9	duplex	duplex	NN
cord-006860-a3b8hyyr	834	10	scanning	scanning	NN
cord-006860-a3b8hyyr	834	11	of	of	IN
cord-006860-a3b8hyyr	834	12	jet	jet	NN
cord-006860-a3b8hyyr	834	13	peak	peak	NN
cord-006860-a3b8hyyr	834	14	velocities	velocity	NNS
cord-006860-a3b8hyyr	834	15	.	.	.
cord-006860-a3b8hyyr	835	1	Restenosis	Restenosis	NNP
cord-006860-a3b8hyyr	835	2	was	be	VBD
cord-006860-a3b8hyyr	835	3	arbitrarily	arbitrarily	RB
cord-006860-a3b8hyyr	835	4	defined	define	VBN
cord-006860-a3b8hyyr	835	5	as	as	IN
cord-006860-a3b8hyyr	835	6	more	more	JJR
cord-006860-a3b8hyyr	835	7	than	than	IN
cord-006860-a3b8hyyr	835	8	50	50	CD
cord-006860-a3b8hyyr	835	9	%	%	NN
cord-006860-a3b8hyyr	835	10	occlusion	occlusion	NN
cord-006860-a3b8hyyr	835	11	of	of	IN
cord-006860-a3b8hyyr	835	12	the	the	DT
cord-006860-a3b8hyyr	835	13	lumen	lumen	NN
cord-006860-a3b8hyyr	835	14	at	at	IN
cord-006860-a3b8hyyr	835	15	the	the	DT
cord-006860-a3b8hyyr	835	16	site	site	NN
cord-006860-a3b8hyyr	835	17	of	of	IN
cord-006860-a3b8hyyr	835	18	dilatation	dilatation	NN
cord-006860-a3b8hyyr	835	19	6	6	CD
cord-006860-a3b8hyyr	835	20	months	month	NNS
cord-006860-a3b8hyyr	835	21	after	after	IN
cord-006860-a3b8hyyr	835	22	successful	successful	JJ
cord-006860-a3b8hyyr	835	23	intervention	intervention	NN
cord-006860-a3b8hyyr	835	24	.	.	.
cord-006860-a3b8hyyr	836	1	Laboratory	laboratory	NN
cord-006860-a3b8hyyr	836	2	investigation	investigation	NN
cord-006860-a3b8hyyr	836	3	at	at	IN
cord-006860-a3b8hyyr	836	4	the	the	DT
cord-006860-a3b8hyyr	836	5	same	same	JJ
cord-006860-a3b8hyyr	836	6	time	time	NN
cord-006860-a3b8hyyr	836	7	included	include	VBD
cord-006860-a3b8hyyr	836	8	aCL	aCL	NNP
cord-006860-a3b8hyyr	836	9	and	and	CC
cord-006860-a3b8hyyr	836	10	other	other	JJ
cord-006860-a3b8hyyr	836	11	known	know	VBN
cord-006860-a3b8hyyr	836	12	atherosklerosis	atherosklerosis	NN
cord-006860-a3b8hyyr	836	13	risk	risk	NN
cord-006860-a3b8hyyr	836	14	markers	marker	NNS
cord-006860-a3b8hyyr	836	15	,	,	,
cord-006860-a3b8hyyr	836	16	such	such	JJ
cord-006860-a3b8hyyr	836	17	as	as	IN
cord-006860-a3b8hyyr	836	18	fibdnogen	fibdnogen	NNP
cord-006860-a3b8hyyr	836	19	(	(	-LRB-
cord-006860-a3b8hyyr	836	20	Fbg	Fbg	NNP
cord-006860-a3b8hyyr	836	21	)	)	-RRB-
cord-006860-a3b8hyyr	836	22	,	,	,
cord-006860-a3b8hyyr	836	23	yon	yon	NNP
cord-006860-a3b8hyyr	836	24	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	836	25	factor	factor	NN
cord-006860-a3b8hyyr	836	26	(	(	-LRB-
cord-006860-a3b8hyyr	836	27	vWF	vWF	NNP
cord-006860-a3b8hyyr	836	28	)	)	-RRB-
cord-006860-a3b8hyyr	836	29	,	,	,
cord-006860-a3b8hyyr	836	30	homocystein	homocystein	NNP
cord-006860-a3b8hyyr	836	31	(	(	-LRB-
cord-006860-a3b8hyyr	836	32	Hcy	Hcy	NNP
cord-006860-a3b8hyyr	836	33	)	)	-RRB-
cord-006860-a3b8hyyr	836	34	,	,	,
cord-006860-a3b8hyyr	836	35	C	c	NN
cord-006860-a3b8hyyr	836	36	-	-	HYPH
cord-006860-a3b8hyyr	836	37	reactive	reactive	JJ
cord-006860-a3b8hyyr	836	38	protein	protein	NN
cord-006860-a3b8hyyr	836	39	(	(	-LRB-
cord-006860-a3b8hyyr	836	40	CRP	CRP	NNP
cord-006860-a3b8hyyr	836	41	)	)	-RRB-
cord-006860-a3b8hyyr	836	42	.	.	.
cord-006860-a3b8hyyr	837	1	Thrombin	Thrombin	NNP
cord-006860-a3b8hyyr	837	2	generation	generation	NN
cord-006860-a3b8hyyr	837	3	markers	marker	NNS
cord-006860-a3b8hyyr	837	4	,	,	,
cord-006860-a3b8hyyr	837	5	such	such	JJ
cord-006860-a3b8hyyr	837	6	as	as	IN
cord-006860-a3b8hyyr	837	7	thrombin	thrombin	NN
cord-006860-a3b8hyyr	837	8	-	-	HYPH
cord-006860-a3b8hyyr	837	9	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	837	10	III	iii	CD
cord-006860-a3b8hyyr	837	11	complexes	complex	NNS
cord-006860-a3b8hyyr	837	12	and	and	CC
cord-006860-a3b8hyyr	837	13	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	837	14	fragments	fragment	NNS
cord-006860-a3b8hyyr	837	15	1	1	CD
cord-006860-a3b8hyyr	837	16	+	+	SYM
cord-006860-a3b8hyyr	837	17	2	2	CD
cord-006860-a3b8hyyr	837	18	,	,	,
cord-006860-a3b8hyyr	837	19	as	as	RB
cord-006860-a3b8hyyr	837	20	well	well	RB
cord-006860-a3b8hyyr	837	21	as	as	IN
cord-006860-a3b8hyyr	837	22	thrombomodulin	thrombomodulin	NNP
cord-006860-a3b8hyyr	837	23	(	(	-LRB-
cord-006860-a3b8hyyr	837	24	FM	FM	NNP
cord-006860-a3b8hyyr	837	25	)	)	-RRB-
cord-006860-a3b8hyyr	837	26	as	as	IN
cord-006860-a3b8hyyr	837	27	an	an	DT
cord-006860-a3b8hyyr	837	28	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	837	29	activation	activation	NN
cord-006860-a3b8hyyr	837	30	marker	marker	NN
cord-006860-a3b8hyyr	837	31	,	,	,
cord-006860-a3b8hyyr	837	32	were	be	VBD
cord-006860-a3b8hyyr	837	33	also	also	RB
cord-006860-a3b8hyyr	837	34	measured	measure	VBN
cord-006860-a3b8hyyr	837	35	.	.	.
cord-006860-a3b8hyyr	838	1	Results	result	NNS
cord-006860-a3b8hyyr	838	2	:	:	:
cord-006860-a3b8hyyr	838	3	31/75	31/75	CD
cord-006860-a3b8hyyr	838	4	(	(	-LRB-
cord-006860-a3b8hyyr	838	5	41.3	41.3	CD
cord-006860-a3b8hyyr	838	6	%	%	NN
cord-006860-a3b8hyyr	838	7	)	)	-RRB-
cord-006860-a3b8hyyr	839	1	patients	patient	NNS
cord-006860-a3b8hyyr	839	2	were	be	VBD
cord-006860-a3b8hyyr	839	3	considered	consider	VBN
cord-006860-a3b8hyyr	839	4	to	to	TO
cord-006860-a3b8hyyr	839	5	have	have	VB
cord-006860-a3b8hyyr	839	6	developed	develop	VBN
cord-006860-a3b8hyyr	839	7	restenosis	restenosis	NN
cord-006860-a3b8hyyr	839	8	after	after	IN
cord-006860-a3b8hyyr	839	9	6	6	CD
cord-006860-a3b8hyyr	839	10	months	month	NNS
cord-006860-a3b8hyyr	839	11	.	.	.
cord-006860-a3b8hyyr	840	1	9/75	9/75	CD
cord-006860-a3b8hyyr	840	2	(	(	-LRB-
cord-006860-a3b8hyyr	840	3	12	12	CD
cord-006860-a3b8hyyr	840	4	%	%	NN
cord-006860-a3b8hyyr	840	5	)	)	-RRB-
cord-006860-a3b8hyyr	840	6	patients	patient	NNS
cord-006860-a3b8hyyr	840	7	were	be	VBD
cord-006860-a3b8hyyr	840	8	found	find	VBN
cord-006860-a3b8hyyr	840	9	to	to	TO
cord-006860-a3b8hyyr	840	10	have	have	VB
cord-006860-a3b8hyyr	840	11	positive	positive	JJ
cord-006860-a3b8hyyr	840	12	IgG-(19	IgG-(19	NNP
cord-006860-a3b8hyyr	840	13	-	-	HYPH
cord-006860-a3b8hyyr	840	14	35	35	CD
cord-006860-a3b8hyyr	840	15	GPL	GPL	NNP
cord-006860-a3b8hyyr	840	16	)	)	-RRB-
cord-006860-a3b8hyyr	840	17	and/or	and/or	CC
cord-006860-a3b8hyyr	841	1	IgM	IgM	NNP
cord-006860-a3b8hyyr	841	2	-	-	HYPH
cord-006860-a3b8hyyr	841	3	aCL	aCL	NNP
cord-006860-a3b8hyyr	841	4	(	(	-LRB-
cord-006860-a3b8hyyr	841	5	14	14	CD
cord-006860-a3b8hyyr	841	6	-	-	SYM
cord-006860-a3b8hyyr	841	7	103	103	CD
cord-006860-a3b8hyyr	841	8	MPL	MPL	NNP
cord-006860-a3b8hyyr	841	9	)	)	-RRB-
cord-006860-a3b8hyyr	841	10	at	at	IN
cord-006860-a3b8hyyr	841	11	all	all	RB
cord-006860-a3b8hyyr	841	12	three	three	CD
cord-006860-a3b8hyyr	841	13	measurements	measurement	NNS
cord-006860-a3b8hyyr	841	14	.	.	.
cord-006860-a3b8hyyr	842	1	1/75	1/75	CD
cord-006860-a3b8hyyr	842	2	was	be	VBD
cord-006860-a3b8hyyr	842	3	negative	negative	JJ
cord-006860-a3b8hyyr	842	4	before	before	RB
cord-006860-a3b8hyyr	842	5	but	but	CC
cord-006860-a3b8hyyr	842	6	seroconverted	seroconverte	VBD
cord-006860-a3b8hyyr	842	7	(	(	-LRB-
cord-006860-a3b8hyyr	842	8	IgM	IgM	NNP
cord-006860-a3b8hyyr	842	9	)	)	-RRB-
cord-006860-a3b8hyyr	842	10	3	3	CD
cord-006860-a3b8hyyr	842	11	months	month	NNS
cord-006860-a3b8hyyr	842	12	after	after	IN
cord-006860-a3b8hyyr	842	13	PTA	PTA	NNP
cord-006860-a3b8hyyr	842	14	.	.	.
cord-006860-a3b8hyyr	843	1	2/10	2/10	CD
cord-006860-a3b8hyyr	843	2	(	(	-LRB-
cord-006860-a3b8hyyr	843	3	20	20	CD
cord-006860-a3b8hyyr	843	4	%	%	NN
cord-006860-a3b8hyyr	843	5	)	)	-RRB-
cord-006860-a3b8hyyr	843	6	aCL	acl	NN
cord-006860-a3b8hyyr	843	7	-	-	HYPH
cord-006860-a3b8hyyr	843	8	positive	positive	JJ
cord-006860-a3b8hyyr	843	9	and	and	CC
cord-006860-a3b8hyyr	843	10	29165	29165	CD
cord-006860-a3b8hyyr	843	11	(	(	-LRB-
cord-006860-a3b8hyyr	843	12	44.6	44.6	CD
cord-006860-a3b8hyyr	843	13	%	%	NN
cord-006860-a3b8hyyr	843	14	)	)	-RRB-
cord-006860-a3b8hyyr	843	15	aCL	acl	NN
cord-006860-a3b8hyyr	843	16	-	-	HYPH
cord-006860-a3b8hyyr	843	17	negative	negative	JJ
cord-006860-a3b8hyyr	843	18	developed	develop	VBN
cord-006860-a3b8hyyr	843	19	restenesis	restenesis	NN
cord-006860-a3b8hyyr	843	20	at	at	IN
cord-006860-a3b8hyyr	843	21	6	6	CD
cord-006860-a3b8hyyr	843	22	months	month	NNS
cord-006860-a3b8hyyr	843	23	(	(	-LRB-
cord-006860-a3b8hyyr	843	24	chi	chi	JJ
cord-006860-a3b8hyyr	843	25	-	-	HYPH
cord-006860-a3b8hyyr	843	26	square	square	JJ
cord-006860-a3b8hyyr	843	27	p	p	NNP
cord-006860-a3b8hyyr	843	28	-	-	:
cord-006860-a3b8hyyr	843	29	value=0.14	value=0.14	NNP
cord-006860-a3b8hyyr	843	30	)	)	-RRB-
cord-006860-a3b8hyyr	843	31	.	.	.
cord-006860-a3b8hyyr	844	1	All	all	DT
cord-006860-a3b8hyyr	844	2	above	above	RB
cord-006860-a3b8hyyr	844	3	mentioned	mention	VBD
cord-006860-a3b8hyyr	844	4	coagulation	coagulation	NN
cord-006860-a3b8hyyr	844	5	parameters	parameter	NNS
cord-006860-a3b8hyyr	844	6	did	do	VBD
cord-006860-a3b8hyyr	844	7	not	not	RB
cord-006860-a3b8hyyr	844	8	differ	differ	VB
cord-006860-a3b8hyyr	844	9	between	between	IN
cord-006860-a3b8hyyr	844	10	aCL	acl	NN
cord-006860-a3b8hyyr	844	11	-	-	HYPH
cord-006860-a3b8hyyr	844	12	positive	positive	JJ
cord-006860-a3b8hyyr	844	13	and	and	CC
cord-006860-a3b8hyyr	844	14	-negative	-negative	JJ
cord-006860-a3b8hyyr	844	15	patients	patient	NNS
cord-006860-a3b8hyyr	844	16	,	,	,
cord-006860-a3b8hyyr	844	17	measured	measure	VBN
cord-006860-a3b8hyyr	844	18	before	before	IN
cord-006860-a3b8hyyr	844	19	or	or	CC
cord-006860-a3b8hyyr	844	20	6	6	CD
cord-006860-a3b8hyyr	844	21	months	month	NNS
cord-006860-a3b8hyyr	844	22	after	after	IN
cord-006860-a3b8hyyr	844	23	PTA	PTA	NNP
cord-006860-a3b8hyyr	844	24	.	.	.
cord-006860-a3b8hyyr	845	1	Some	some	DT
cord-006860-a3b8hyyr	845	2	of	of	IN
cord-006860-a3b8hyyr	845	3	them	-PRON-	PRP
cord-006860-a3b8hyyr	845	4	are	be	VBP
cord-006860-a3b8hyyr	845	5	shown	show	VBN
cord-006860-a3b8hyyr	845	6	below	below	IN
cord-006860-a3b8hyyr	845	7	(	(	-LRB-
cord-006860-a3b8hyyr	845	8	values	value	NNS
cord-006860-a3b8hyyr	845	9	before	before	IN
cord-006860-a3b8hyyr	845	10	PTA	PTA	NNP
cord-006860-a3b8hyyr	845	11	)	)	-RRB-
cord-006860-a3b8hyyr	845	12	:	:	:
cord-006860-a3b8hyyr	846	1	Fbg	Fbg	NNP
cord-006860-a3b8hyyr	846	2	(	(	-LRB-
cord-006860-a3b8hyyr	846	3	Basilar	Basilar	NNP
cord-006860-a3b8hyyr	846	4	artery	artery	NN
cord-006860-a3b8hyyr	846	5	stenosis	stenosis	NN
cord-006860-a3b8hyyr	846	6	is	be	VBZ
cord-006860-a3b8hyyr	846	7	a	a	DT
cord-006860-a3b8hyyr	846	8	rare	rare	JJ
cord-006860-a3b8hyyr	846	9	event	event	NN
cord-006860-a3b8hyyr	846	10	in	in	IN
cord-006860-a3b8hyyr	846	11	young	young	JJ
cord-006860-a3b8hyyr	846	12	children	child	NNS
cord-006860-a3b8hyyr	846	13	.	.	.
cord-006860-a3b8hyyr	847	1	Risk	risk	NN
cord-006860-a3b8hyyr	847	2	factors	factor	NNS
cord-006860-a3b8hyyr	847	3	are	be	VBP
cord-006860-a3b8hyyr	847	4	head	head	NN
cord-006860-a3b8hyyr	847	5	or	or	CC
cord-006860-a3b8hyyr	847	6	neck	neck	NN
cord-006860-a3b8hyyr	847	7	trauma	trauma	NN
cord-006860-a3b8hyyr	847	8	with	with	IN
cord-006860-a3b8hyyr	847	9	consecutive	consecutive	JJ
cord-006860-a3b8hyyr	847	10	dissection	dissection	NN
cord-006860-a3b8hyyr	847	11	of	of	IN
cord-006860-a3b8hyyr	847	12	the	the	DT
cord-006860-a3b8hyyr	847	13	vertebral	vertebral	JJ
cord-006860-a3b8hyyr	847	14	artery	artery	NN
cord-006860-a3b8hyyr	847	15	,	,	,
cord-006860-a3b8hyyr	847	16	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	847	17	diseases	disease	NNS
cord-006860-a3b8hyyr	847	18	or	or	CC
cord-006860-a3b8hyyr	847	19	hypercoagulability	hypercoagulability	NN
cord-006860-a3b8hyyr	847	20	.	.	.
cord-006860-a3b8hyyr	848	1	Elevated	elevated	JJ
cord-006860-a3b8hyyr	848	2	lipoprotein	lipoprotein	NN
cord-006860-a3b8hyyr	848	3	(	(	-LRB-
cord-006860-a3b8hyyr	848	4	a	a	NN
cord-006860-a3b8hyyr	848	5	)	)	-RRB-
cord-006860-a3b8hyyr	848	6	(	(	-LRB-
cord-006860-a3b8hyyr	848	7	Lp(a	Lp(a	NNP
cord-006860-a3b8hyyr	848	8	)	)	-RRB-
cord-006860-a3b8hyyr	848	9	)	)	-RRB-
cord-006860-a3b8hyyr	849	1	serum	serum	NN
cord-006860-a3b8hyyr	849	2	levels	level	NNS
cord-006860-a3b8hyyr	849	3	in	in	IN
cord-006860-a3b8hyyr	849	4	adults	adult	NNS
cord-006860-a3b8hyyr	849	5	can	can	MD
cord-006860-a3b8hyyr	849	6	mediate	mediate	VB
cord-006860-a3b8hyyr	849	7	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	849	8	.	.	.
cord-006860-a3b8hyyr	850	1	In	in	IN
cord-006860-a3b8hyyr	850	2	addition	addition	NN
cord-006860-a3b8hyyr	850	3	,	,	,
cord-006860-a3b8hyyr	850	4	Lp(a	Lp(a	NNP
cord-006860-a3b8hyyr	850	5	)	)	-RRB-
cord-006860-a3b8hyyr	850	6	might	may	MD
cord-006860-a3b8hyyr	850	7	interfere	interfere	VB
cord-006860-a3b8hyyr	850	8	with	with	IN
cord-006860-a3b8hyyr	850	9	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	850	10	.	.	.
cord-006860-a3b8hyyr	851	1	Here	here	RB
cord-006860-a3b8hyyr	851	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	851	3	report	report	VBP
cord-006860-a3b8hyyr	851	4	on	on	IN
cord-006860-a3b8hyyr	851	5	a	a	DT
cord-006860-a3b8hyyr	851	6	3	3	CD
cord-006860-a3b8hyyr	851	7	year	year	NN
cord-006860-a3b8hyyr	851	8	old	old	JJ
cord-006860-a3b8hyyr	851	9	boy	boy	NN
cord-006860-a3b8hyyr	851	10	,	,	,
cord-006860-a3b8hyyr	851	11	who	who	WP
cord-006860-a3b8hyyr	851	12	presented	present	VBD
cord-006860-a3b8hyyr	851	13	with	with	IN
cord-006860-a3b8hyyr	851	14	acute	acute	JJ
cord-006860-a3b8hyyr	851	15	brain	brain	NN
cord-006860-a3b8hyyr	851	16	stem	stem	NN
cord-006860-a3b8hyyr	851	17	symptoms	symptom	NNS
cord-006860-a3b8hyyr	851	18	.	.	.
cord-006860-a3b8hyyr	852	1	History	history	NN
cord-006860-a3b8hyyr	852	2	revealed	reveal	VBD
cord-006860-a3b8hyyr	852	3	neither	neither	CC
cord-006860-a3b8hyyr	852	4	trauma	trauma	NN
cord-006860-a3b8hyyr	852	5	nor	nor	CC
cord-006860-a3b8hyyr	852	6	infectious	infectious	JJ
cord-006860-a3b8hyyr	852	7	disease	disease	NN
cord-006860-a3b8hyyr	852	8	.	.	.
cord-006860-a3b8hyyr	853	1	Conventional	Conventional	NNP
cord-006860-a3b8hyyr	853	2	and	and	CC
cord-006860-a3b8hyyr	853	3	MR	MR	NNP
cord-006860-a3b8hyyr	853	4	angiography	angiography	NN
cord-006860-a3b8hyyr	853	5	showed	show	VBD
cord-006860-a3b8hyyr	853	6	stenosis	stenosis	NN
cord-006860-a3b8hyyr	853	7	of	of	IN
cord-006860-a3b8hyyr	853	8	basilar	basilar	JJ
cord-006860-a3b8hyyr	853	9	artery	artery	NN
cord-006860-a3b8hyyr	853	10	without	without	IN
cord-006860-a3b8hyyr	853	11	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	853	12	lesions	lesion	NNS
cord-006860-a3b8hyyr	853	13	.	.	.
cord-006860-a3b8hyyr	854	1	Laboratory	laboratory	NN
cord-006860-a3b8hyyr	854	2	findings	finding	NNS
cord-006860-a3b8hyyr	854	3	were	be	VBD
cord-006860-a3b8hyyr	854	4	normal	normal	JJ
cord-006860-a3b8hyyr	854	5	in	in	IN
cord-006860-a3b8hyyr	854	6	routine	routine	JJ
cord-006860-a3b8hyyr	854	7	blood	blood	NN
cord-006860-a3b8hyyr	854	8	and	and	CC
cord-006860-a3b8hyyr	854	9	CSF	csf	NN
cord-006860-a3b8hyyr	854	10	tests	test	NNS
cord-006860-a3b8hyyr	854	11	.	.	.
cord-006860-a3b8hyyr	855	1	Global	global	JJ
cord-006860-a3b8hyyr	855	2	coagulation	coagulation	NN
cord-006860-a3b8hyyr	855	3	parameters	parameter	NNS
cord-006860-a3b8hyyr	855	4	as	as	RB
cord-006860-a3b8hyyr	855	5	well	well	RB
cord-006860-a3b8hyyr	855	6	as	as	IN
cord-006860-a3b8hyyr	855	7	procoagulant	procoagulant	NN
cord-006860-a3b8hyyr	855	8	and	and	CC
cord-006860-a3b8hyyr	855	9	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	855	10	factors	factor	NNS
cord-006860-a3b8hyyr	855	11	were	be	VBD
cord-006860-a3b8hyyr	855	12	normal	normal	JJ
cord-006860-a3b8hyyr	855	13	.	.	.
cord-006860-a3b8hyyr	856	1	Cardiac	cardiac	JJ
cord-006860-a3b8hyyr	856	2	and	and	CC
cord-006860-a3b8hyyr	856	3	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	856	4	disease	disease	NN
cord-006860-a3b8hyyr	856	5	could	could	MD
cord-006860-a3b8hyyr	856	6	be	be	VB
cord-006860-a3b8hyyr	856	7	ruled	rule	VBN
cord-006860-a3b8hyyr	856	8	out	out	RP
cord-006860-a3b8hyyr	856	9	.	.	.
cord-006860-a3b8hyyr	857	1	Lp(a	Lp(a	NNP
cord-006860-a3b8hyyr	857	2	)	)	-RRB-
cord-006860-a3b8hyyr	858	1	serum	serum	NN
cord-006860-a3b8hyyr	858	2	levels	level	NNS
cord-006860-a3b8hyyr	858	3	were	be	VBD
cord-006860-a3b8hyyr	858	4	significantly	significantly	RB
cord-006860-a3b8hyyr	858	5	elevated	elevate	VBN
cord-006860-a3b8hyyr	858	6	to	to	IN
cord-006860-a3b8hyyr	858	7	104	104	CD
cord-006860-a3b8hyyr	858	8	mg	mg	NNP
cord-006860-a3b8hyyr	858	9	/	/	SYM
cord-006860-a3b8hyyr	858	10	dl	dl	NN
cord-006860-a3b8hyyr	858	11	(	(	-LRB-
cord-006860-a3b8hyyr	858	12	normal	normal	JJ
cord-006860-a3b8hyyr	858	13	range	range	NN
cord-006860-a3b8hyyr	858	14	<	<	XX
cord-006860-a3b8hyyr	858	15	30	30	CD
cord-006860-a3b8hyyr	858	16	mg	mg	NNP
cord-006860-a3b8hyyr	858	17	/	/	SYM
cord-006860-a3b8hyyr	858	18	dl	dl	NNP
cord-006860-a3b8hyyr	858	19	)	)	-RRB-
cord-006860-a3b8hyyr	858	20	.	.	.
cord-006860-a3b8hyyr	859	1	Analysis	analysis	NN
cord-006860-a3b8hyyr	859	2	of	of	IN
cord-006860-a3b8hyyr	859	3	other	other	JJ
cord-006860-a3b8hyyr	859	4	family	family	NN
cord-006860-a3b8hyyr	859	5	members	member	NNS
cord-006860-a3b8hyyr	859	6	revealed	reveal	VBD
cord-006860-a3b8hyyr	859	7	a	a	DT
cord-006860-a3b8hyyr	859	8	hereditary	hereditary	JJ
cord-006860-a3b8hyyr	859	9	hyperlipoproteinemia	hyperlipoproteinemia	NN
cord-006860-a3b8hyyr	859	10	(	(	-LRB-
cord-006860-a3b8hyyr	859	11	a	a	NN
cord-006860-a3b8hyyr	859	12	)	)	-RRB-
cord-006860-a3b8hyyr	859	13	which	which	WDT
cord-006860-a3b8hyyr	859	14	might	may	MD
cord-006860-a3b8hyyr	859	15	explain	explain	VB
cord-006860-a3b8hyyr	859	16	family	family	NN
cord-006860-a3b8hyyr	859	17	history	history	NN
cord-006860-a3b8hyyr	859	18	of	of	IN
cord-006860-a3b8hyyr	859	19	an	an	DT
cord-006860-a3b8hyyr	859	20	increased	increase	VBN
cord-006860-a3b8hyyr	859	21	incidence	incidence	NN
cord-006860-a3b8hyyr	859	22	of	of	IN
cord-006860-a3b8hyyr	859	23	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	859	24	infarction	infarction	NN
cord-006860-a3b8hyyr	859	25	and	and	CC
cord-006860-a3b8hyyr	859	26	CVE	CVE	NNP
cord-006860-a3b8hyyr	859	27	in	in	IN
cord-006860-a3b8hyyr	859	28	elderly	elderly	JJ
cord-006860-a3b8hyyr	859	29	family	family	NN
cord-006860-a3b8hyyr	859	30	members	member	NNS
cord-006860-a3b8hyyr	859	31	.	.	.
cord-006860-a3b8hyyr	860	1	Clinically	clinically	RB
cord-006860-a3b8hyyr	860	2	the	the	DT
cord-006860-a3b8hyyr	860	3	patient	patient	NN
cord-006860-a3b8hyyr	860	4	recovered	recover	VBD
cord-006860-a3b8hyyr	860	5	completely	completely	RB
cord-006860-a3b8hyyr	860	6	from	from	IN
cord-006860-a3b8hyyr	860	7	brain	brain	NN
cord-006860-a3b8hyyr	860	8	stem	stem	NN
cord-006860-a3b8hyyr	860	9	symptoms	symptom	NNS
cord-006860-a3b8hyyr	860	10	after	after	IN
cord-006860-a3b8hyyr	860	11	heparinization	heparinization	NN
cord-006860-a3b8hyyr	860	12	and	and	CC
cord-006860-a3b8hyyr	860	13	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	860	14	oral	oral	JJ
cord-006860-a3b8hyyr	860	15	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	860	16	with	with	IN
cord-006860-a3b8hyyr	860	17	phenprocoumon	phenprocoumon	NNP
cord-006860-a3b8hyyr	860	18	.	.	.
cord-006860-a3b8hyyr	861	1	However	however	RB
cord-006860-a3b8hyyr	861	2	,	,	,
cord-006860-a3b8hyyr	861	3	radiological	radiological	JJ
cord-006860-a3b8hyyr	861	4	signs	sign	NNS
cord-006860-a3b8hyyr	861	5	of	of	IN
cord-006860-a3b8hyyr	861	6	basilar	basilar	JJ
cord-006860-a3b8hyyr	861	7	artery	artery	NN
cord-006860-a3b8hyyr	861	8	stenosis	stenosis	NN
cord-006860-a3b8hyyr	861	9	were	be	VBD
cord-006860-a3b8hyyr	861	10	progredient	progredient	JJ
cord-006860-a3b8hyyr	861	11	.	.	.
cord-006860-a3b8hyyr	862	1	In	in	IN
cord-006860-a3b8hyyr	862	2	a	a	DT
cord-006860-a3b8hyyr	862	3	recently	recently	RB
cord-006860-a3b8hyyr	862	4	developed	develop	VBN
cord-006860-a3b8hyyr	862	5	specific	specific	JJ
cord-006860-a3b8hyyr	862	6	test	test	NN
cord-006860-a3b8hyyr	862	7	,	,	,
cord-006860-a3b8hyyr	862	8	an	an	DT
cord-006860-a3b8hyyr	862	9	elevated	elevated	JJ
cord-006860-a3b8hyyr	862	10	anti	anti	JJ
cord-006860-a3b8hyyr	862	11	-	-	JJ
cord-006860-a3b8hyyr	862	12	phosphatidylserin	phosphatidylserin	JJ
cord-006860-a3b8hyyr	862	13	antibody	antibody	NN
cord-006860-a3b8hyyr	862	14	titer	titer	NN
cord-006860-a3b8hyyr	862	15	was	be	VBD
cord-006860-a3b8hyyr	862	16	detected	detect	VBN
cord-006860-a3b8hyyr	862	17	one	one	CD
cord-006860-a3b8hyyr	862	18	year	year	NN
cord-006860-a3b8hyyr	862	19	after	after	IN
cord-006860-a3b8hyyr	862	20	primary	primary	JJ
cord-006860-a3b8hyyr	862	21	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	862	22	.	.	.
cord-006860-a3b8hyyr	863	1	In	in	IN
cord-006860-a3b8hyyr	863	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	863	3	,	,	,
cord-006860-a3b8hyyr	863	4	this	this	DT
cord-006860-a3b8hyyr	863	5	is	be	VBZ
cord-006860-a3b8hyyr	863	6	the	the	DT
cord-006860-a3b8hyyr	863	7	first	first	JJ
cord-006860-a3b8hyyr	863	8	report	report	NN
cord-006860-a3b8hyyr	863	9	on	on	IN
cord-006860-a3b8hyyr	863	10	a	a	DT
cord-006860-a3b8hyyr	863	11	child	child	NN
cord-006860-a3b8hyyr	863	12	with	with	IN
cord-006860-a3b8hyyr	863	13	stenosis	stenosis	NN
cord-006860-a3b8hyyr	863	14	of	of	IN
cord-006860-a3b8hyyr	863	15	the	the	DT
cord-006860-a3b8hyyr	863	16	basilar	basilar	JJ
cord-006860-a3b8hyyr	863	17	artery	artery	NN
cord-006860-a3b8hyyr	863	18	and	and	CC
cord-006860-a3b8hyyr	863	19	elevated	elevated	JJ
cord-006860-a3b8hyyr	863	20	levels	level	NNS
cord-006860-a3b8hyyr	863	21	of	of	IN
cord-006860-a3b8hyyr	863	22	Lp	Lp	NNP
cord-006860-a3b8hyyr	863	23	(	(	-LRB-
cord-006860-a3b8hyyr	863	24	a	a	NN
cord-006860-a3b8hyyr	863	25	)	)	-RRB-
cord-006860-a3b8hyyr	863	26	.	.	.
cord-006860-a3b8hyyr	864	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	864	2	is	be	VBZ
cord-006860-a3b8hyyr	864	3	unclear	unclear	JJ
cord-006860-a3b8hyyr	864	4	,	,	,
cord-006860-a3b8hyyr	864	5	whether	whether	IN
cord-006860-a3b8hyyr	864	6	APA	APA	NNP
cord-006860-a3b8hyyr	864	7	contributed	contribute	VBD
cord-006860-a3b8hyyr	864	8	to	to	IN
cord-006860-a3b8hyyr	864	9	the	the	DT
cord-006860-a3b8hyyr	864	10	onset	onset	NN
cord-006860-a3b8hyyr	864	11	of	of	IN
cord-006860-a3b8hyyr	864	12	basilar	basilar	JJ
cord-006860-a3b8hyyr	864	13	artery	artery	NN
cord-006860-a3b8hyyr	864	14	stenosis	stenosis	NN
cord-006860-a3b8hyyr	864	15	or	or	CC
cord-006860-a3b8hyyr	864	16	developed	develop	VBN
cord-006860-a3b8hyyr	864	17	secondary	secondary	JJ
cord-006860-a3b8hyyr	864	18	due	due	IN
cord-006860-a3b8hyyr	864	19	to	to	IN
cord-006860-a3b8hyyr	864	20	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	864	21	defects	defect	NNS
cord-006860-a3b8hyyr	864	22	after	after	IN
cord-006860-a3b8hyyr	864	23	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	864	24	and	and	CC
cord-006860-a3b8hyyr	864	25	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	864	26	.	.	.
cord-006860-a3b8hyyr	865	1	APA	APA	NNP
cord-006860-a3b8hyyr	865	2	,	,	,
cord-006860-a3b8hyyr	865	3	however	however	RB
cord-006860-a3b8hyyr	865	4	,	,	,
cord-006860-a3b8hyyr	865	5	might	may	MD
cord-006860-a3b8hyyr	865	6	increase	increase	VB
cord-006860-a3b8hyyr	865	7	the	the	DT
cord-006860-a3b8hyyr	865	8	risk	risk	NN
cord-006860-a3b8hyyr	865	9	of	of	IN
cord-006860-a3b8hyyr	865	10	further	further	JJ
cord-006860-a3b8hyyr	865	11	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	865	12	events	event	NNS
cord-006860-a3b8hyyr	865	13	in	in	IN
cord-006860-a3b8hyyr	865	14	this	this	DT
cord-006860-a3b8hyyr	865	15	patient	patient	NN
cord-006860-a3b8hyyr	865	16	.	.	.
cord-006860-a3b8hyyr	866	1	In	in	IN
cord-006860-a3b8hyyr	866	2	110	110	CD
cord-006860-a3b8hyyr	866	3	patients	patient	NNS
cord-006860-a3b8hyyr	866	4	with	with	IN
cord-006860-a3b8hyyr	866	5	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	866	6	events	event	NNS
cord-006860-a3b8hyyr	866	7	respectively	respectively	RB
cord-006860-a3b8hyyr	866	8	patients	patient	NNS
cord-006860-a3b8hyyr	866	9	with	with	IN
cord-006860-a3b8hyyr	866	10	systemic	systemic	JJ
cord-006860-a3b8hyyr	866	11	lupus	lupus	NN
cord-006860-a3b8hyyr	866	12	erythematodes	erythematode	VBZ
cord-006860-a3b8hyyr	866	13	antioardiolipin	antioardiolipin	NNP
cord-006860-a3b8hyyr	866	14	antibodies	antibody	NNS
cord-006860-a3b8hyyr	867	1	(	(	-LRB-
cord-006860-a3b8hyyr	867	2	ACA	ACA	NNP
cord-006860-a3b8hyyr	867	3	)	)	-RRB-
cord-006860-a3b8hyyr	867	4	aund	aund	NNP
cord-006860-a3b8hyyr	867	5	lupus	lupus	NN
cord-006860-a3b8hyyr	867	6	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	867	7	(	(	-LRB-
cord-006860-a3b8hyyr	867	8	LA	LA	NNP
cord-006860-a3b8hyyr	867	9	)	)	-RRB-
cord-006860-a3b8hyyr	867	10	were	be	VBD
cord-006860-a3b8hyyr	867	11	~ea	~ea	NNP
cord-006860-a3b8hyyr	868	1	~ured	~ured	JJ
cord-006860-a3b8hyyr	868	2	.	.	.
cord-006860-a3b8hyyr	869	1	For	for	IN
cord-006860-a3b8hyyr	869	2	ACA	ACA	NNP
cord-006860-a3b8hyyr	869	3	detecting	detect	VBG
cord-006860-a3b8hyyr	869	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	869	5	use	use	VBP
cord-006860-a3b8hyyr	869	6	the	the	DT
cord-006860-a3b8hyyr	869	7	assays	assay	NNS
cord-006860-a3b8hyyr	869	8	from	from	IN
cord-006860-a3b8hyyr	869	9	elias	elias	NNP
cord-006860-a3b8hyyr	869	10	for	for	IN
cord-006860-a3b8hyyr	869	11	IgG	IgG	NNP
cord-006860-a3b8hyyr	869	12	-	-	:
cord-006860-a3b8hyyr	869	13	and	and	CC
cord-006860-a3b8hyyr	869	14	Ig~}-antibodies	Ig~}-antibodies	NNP
cord-006860-a3b8hyyr	869	15	.	.	.
cord-006860-a3b8hyyr	870	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	870	2	use	use	VBP
cord-006860-a3b8hyyr	870	3	as	as	IN
cord-006860-a3b8hyyr	870	4	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	870	5	methods	method	NNS
cord-006860-a3b8hyyr	870	6	for	for	IN
cord-006860-a3b8hyyr	870	7	detecting	detect	VBG
cord-006860-a3b8hyyr	870	8	LA	LA	NNP
cord-006860-a3b8hyyr	870	9	in	in	IN
cord-006860-a3b8hyyr	870	10	our	-PRON-	PRP$
cord-006860-a3b8hyyr	870	11	laboratory	laboratory	NN
cord-006860-a3b8hyyr	870	12	the	the	DT
cord-006860-a3b8hyyr	870	13	testkits	testkit	NNS
cord-006860-a3b8hyyr	870	14	from	from	IN
cord-006860-a3b8hyyr	870	15	Diagnostlca	Diagnostlca	NNP
cord-006860-a3b8hyyr	870	16	Stago	Stago	NNP
cord-006860-a3b8hyyr	870	17	(	(	-LRB-
cord-006860-a3b8hyyr	870	18	Staclot	Staclot	NNP
cord-006860-a3b8hyyr	870	19	LA	LA	NNP
cord-006860-a3b8hyyr	870	20	with	with	IN
cord-006860-a3b8hyyr	870	21	hexagonal	hexagonal	JJ
cord-006860-a3b8hyyr	870	22	array	array	NN
cord-006860-a3b8hyyr	870	23	of	of	IN
cord-006860-a3b8hyyr	870	24	phospholipids	phospholipid	NNS
cord-006860-a3b8hyyr	870	25	,	,	,
cord-006860-a3b8hyyr	870	26	,	,	,
cord-006860-a3b8hyyr	870	27	PTT	PTT	NNP
cord-006860-a3b8hyyr	870	28	-	-	HYPH
cord-006860-a3b8hyyr	870	29	LA	LA	NNP
cord-006860-a3b8hyyr	871	1	a	a	DT
cord-006860-a3b8hyyr	871	2	very	very	RB
cord-006860-a3b8hyyr	871	3	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	871	4	PTTmethod	pttmethod	NN
cord-006860-a3b8hyyr	871	5	and	and	CC
cord-006860-a3b8hyyr	871	6	Staclot	Staclot	NNP
cord-006860-a3b8hyyr	871	7	P	P	NNP
cord-006860-a3b8hyyr	872	1	~P	~p	LS
cord-006860-a3b8hyyr	872	2	-	-	:
cord-006860-a3b8hyyr	872	3	a	a	DT
cord-006860-a3b8hyyr	872	4	platelet	platelet	NN
cord-006860-a3b8hyyr	872	5	neutralization	neutralization	NN
cord-006860-a3b8hyyr	872	6	procedure	procedure	NN
cord-006860-a3b8hyyr	872	7	)	)	-RRB-
cord-006860-a3b8hyyr	872	8	and	and	CC
cord-006860-a3b8hyyr	872	9	the	the	DT
cord-006860-a3b8hyyr	872	10	PTT	PTT	NNP
cord-006860-a3b8hyyr	872	11	from	from	IN
cord-006860-a3b8hyyr	872	12	Organon	Organon	NNP
cord-006860-a3b8hyyr	872	13	Teknik~	Teknik~	.
cord-006860-a3b8hyyr	873	1	(	(	-LRB-
cord-006860-a3b8hyyr	873	2	Platelin	Platelin	NNP
cord-006860-a3b8hyyr	873	3	Excel	Excel	NNP
cord-006860-a3b8hyyr	873	4	LS	LS	NNP
cord-006860-a3b8hyyr	873	5	with	with	IN
cord-006860-a3b8hyyr	873	6	two	two	CD
cord-006860-a3b8hyyr	873	7	incubation	incubation	NN
cord-006860-a3b8hyyr	873	8	times	time	NNS
cord-006860-a3b8hyyr	873	9	,	,	,
cord-006860-a3b8hyyr	873	10	1	1	CD
cord-006860-a3b8hyyr	873	11	and	and	CC
cord-006860-a3b8hyyr	873	12	10	10	CD
cord-006860-a3b8hyyr	873	13	minutes	minute	NNS
cord-006860-a3b8hyyr	873	14	)	)	-RRB-
cord-006860-a3b8hyyr	873	15	.	.	.
cord-006860-a3b8hyyr	874	1	i"~e	i"~e	JJ
cord-006860-a3b8hyyr	874	2	results	result	NNS
cord-006860-a3b8hyyr	874	3	Of	of	IN
cord-006860-a3b8hyyr	874	4	this	this	DT
cord-006860-a3b8hyyr	874	5	tests	test	NNS
cord-006860-a3b8hyyr	874	6	were	be	VBD
cord-006860-a3b8hyyr	874	7	compared	compare	VBN
cord-006860-a3b8hyyr	874	8	with	with	IN
cord-006860-a3b8hyyr	874	9	three	three	CD
cord-006860-a3b8hyyr	874	10	new	new	JJ
cord-006860-a3b8hyyr	874	11	or	or	CC
cord-006860-a3b8hyyr	874	12	~	~	NFP
cord-006860-a3b8hyyr	874	13	e	e	XX
cord-006860-a3b8hyyr	874	14	on	on	IN
cord-006860-a3b8hyyr	874	15	German	german	JJ
cord-006860-a3b8hyyr	874	16	market	market	NN
cord-006860-a3b8hyyr	874	17	:	:	:
cord-006860-a3b8hyyr	874	18	SpeckTin	SpeckTin	NNP
cord-006860-a3b8hyyr	874	19	APOT	APOT	NNP
cord-006860-a3b8hyyr	874	20	(	(	-LRB-
cord-006860-a3b8hyyr	874	21	aktlvated	aktlvate	VBN
cord-006860-a3b8hyyr	874	22	plasma	plasma	NN
cord-006860-a3b8hyyr	874	23	clotting	clotting	NN
cord-006860-a3b8hyyr	874	24	time	time	NN
cord-006860-a3b8hyyr	874	25	)	)	-RRB-
cord-006860-a3b8hyyr	874	26	,	,	,
cord-006860-a3b8hyyr	874	27	SpeckTin	SpeckTin	NNP
cord-006860-a3b8hyyr	874	28	APTT	APTT	NNP
cord-006860-a3b8hyyr	875	1	(	(	-LRB-
cord-006860-a3b8hyyr	875	2	APTT	APTT	NNP
cord-006860-a3b8hyyr	875	3	wlth	wlth	NN
cord-006860-a3b8hyyr	875	4	purified	purify	VBN
cord-006860-a3b8hyyr	875	5	soy	soy	NN
cord-006860-a3b8hyyr	875	6	extract	extract	NN
cord-006860-a3b8hyyr	875	7	)	)	-RRB-
cord-006860-a3b8hyyr	875	8	and	and	CC
cord-006860-a3b8hyyr	875	9	8peckTin	8pecktin	CD
cord-006860-a3b8hyyr	875	10	LA	LA	NNP
cord-006860-a3b8hyyr	875	11	(	(	-LRB-
cord-006860-a3b8hyyr	875	12	phospholipid	phospholipid	NN
cord-006860-a3b8hyyr	875	13	preparation	preparation	NN
cord-006860-a3b8hyyr	875	14	in	in	IN
cord-006860-a3b8hyyr	875	15	concentrations	concentration	NNS
cord-006860-a3b8hyyr	875	16	between	between	IN
cord-006860-a3b8hyyr	875	17	10	10	CD
cord-006860-a3b8hyyr	875	18	and	and	CC
cord-006860-a3b8hyyr	875	19	500	500	CD
cord-006860-a3b8hyyr	875	20	~g	~g	NNP
cord-006860-a3b8hyyr	875	21	/	/	SYM
cord-006860-a3b8hyyr	875	22	ml	ml	NN
cord-006860-a3b8hyyr	875	23	)	)	-RRB-
cord-006860-a3b8hyyr	875	24	;	;	:
cord-006860-a3b8hyyr	875	25	all	all	DT
cord-006860-a3b8hyyr	875	26	WAK	WAK	NNP
cord-006860-a3b8hyyr	875	27	Chemie	Chemie	NNP
cord-006860-a3b8hyyr	875	28	.	.	.
cord-006860-a3b8hyyr	876	1	Traditional	traditional	JJ
cord-006860-a3b8hyyr	876	2	aPTT	aptt	JJ
cord-006860-a3b8hyyr	876	3	reagents	reagent	NNS
cord-006860-a3b8hyyr	876	4	were	be	VBD
cord-006860-a3b8hyyr	876	5	developed	develop	VBN
cord-006860-a3b8hyyr	876	6	for	for	IN
cord-006860-a3b8hyyr	876	7	the	the	DT
cord-006860-a3b8hyyr	876	8	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	876	9	detection	detection	NN
cord-006860-a3b8hyyr	876	10	of	of	IN
cord-006860-a3b8hyyr	876	11	factor	factor	NN
cord-006860-a3b8hyyr	876	12	VIB	VIB	NNP
cord-006860-a3b8hyyr	876	13	an	an	DT
cord-006860-a3b8hyyr	876	14	IX	IX	NNP
cord-006860-a3b8hyyr	876	15	as	as	IN
cord-006860-a3b8hyyr	876	16	a	a	DT
cord-006860-a3b8hyyr	876	17	cause	cause	NN
cord-006860-a3b8hyyr	876	18	of	of	IN
cord-006860-a3b8hyyr	876	19	hemorhage	hemorhage	NN
cord-006860-a3b8hyyr	876	20	.	.	.
cord-006860-a3b8hyyr	877	1	High	high	JJ
cord-006860-a3b8hyyr	877	2	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	877	3	against	against	IN
cord-006860-a3b8hyyr	877	4	Lupus	Lupus	NNP
cord-006860-a3b8hyyr	877	5	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	877	6	,	,	,
cord-006860-a3b8hyyr	877	7	which	which	WDT
cord-006860-a3b8hyyr	877	8	also	also	RB
cord-006860-a3b8hyyr	877	9	prolong	prolong	VBP
cord-006860-a3b8hyyr	877	10	aPTT	aptt	CD
cord-006860-a3b8hyyr	877	11	,	,	,
cord-006860-a3b8hyyr	877	12	was	be	VBD
cord-006860-a3b8hyyr	877	13	not	not	RB
cord-006860-a3b8hyyr	877	14	required	require	VBN
cord-006860-a3b8hyyr	877	15	for	for	IN
cord-006860-a3b8hyyr	877	16	this	this	DT
cord-006860-a3b8hyyr	877	17	purpose	purpose	NN
cord-006860-a3b8hyyr	877	18	,	,	,
cord-006860-a3b8hyyr	877	19	With	with	IN
cord-006860-a3b8hyyr	877	20	increasing	increase	VBG
cord-006860-a3b8hyyr	877	21	recognition	recognition	NN
cord-006860-a3b8hyyr	877	22	of	of	IN
cord-006860-a3b8hyyr	877	23	the	the	DT
cord-006860-a3b8hyyr	877	24	importance	importance	NN
cord-006860-a3b8hyyr	877	25	of	of	IN
cord-006860-a3b8hyyr	877	26	antiphospholipid	antiphospholipid	NNP
cord-006860-a3b8hyyr	877	27	antibodies	antibody	NNS
cord-006860-a3b8hyyr	877	28	as	as	IN
cord-006860-a3b8hyyr	877	29	a	a	DT
cord-006860-a3b8hyyr	877	30	risk	risk	NN
cord-006860-a3b8hyyr	877	31	factor	factor	NN
cord-006860-a3b8hyyr	877	32	for	for	IN
cord-006860-a3b8hyyr	877	33	thrombembolism	thrombembolism	NN
cord-006860-a3b8hyyr	877	34	,	,	,
cord-006860-a3b8hyyr	877	35	more	more	RBR
cord-006860-a3b8hyyr	877	36	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	877	37	reagents	reagent	NNS
cord-006860-a3b8hyyr	877	38	were	be	VBD
cord-006860-a3b8hyyr	877	39	designed	design	VBN
cord-006860-a3b8hyyr	877	40	,	,	,
cord-006860-a3b8hyyr	877	41	which	which	WDT
cord-006860-a3b8hyyr	877	42	now	now	RB
cord-006860-a3b8hyyr	877	43	reliable	reliable	JJ
cord-006860-a3b8hyyr	877	44	detect	detect	VBP
cord-006860-a3b8hyyr	877	45	this	this	DT
cord-006860-a3b8hyyr	877	46	condition	condition	NN
cord-006860-a3b8hyyr	877	47	.	.	.
cord-006860-a3b8hyyr	878	1	Using	use	VBG
cord-006860-a3b8hyyr	878	2	such	such	JJ
cord-006860-a3b8hyyr	878	3	reagents	reagent	NNS
cord-006860-a3b8hyyr	878	4	as	as	IN
cord-006860-a3b8hyyr	878	5	a	a	DT
cord-006860-a3b8hyyr	878	6	screening	screening	NN
cord-006860-a3b8hyyr	878	7	test	test	NN
cord-006860-a3b8hyyr	878	8	in	in	IN
cord-006860-a3b8hyyr	878	9	a	a	DT
cord-006860-a3b8hyyr	878	10	general	general	JJ
cord-006860-a3b8hyyr	878	11	hospital	hospital	NN
cord-006860-a3b8hyyr	878	12	makes	make	VBZ
cord-006860-a3b8hyyr	878	13	it	-PRON-	PRP
cord-006860-a3b8hyyr	878	14	necessary	necessary	JJ
cord-006860-a3b8hyyr	878	15	to	to	TO
cord-006860-a3b8hyyr	878	16	distinguish	distinguish	VB
cord-006860-a3b8hyyr	878	17	both	both	DT
cord-006860-a3b8hyyr	878	18	conditions	condition	NNS
cord-006860-a3b8hyyr	878	19	quickly	quickly	RB
cord-006860-a3b8hyyr	878	20	.	.	.
cord-006860-a3b8hyyr	879	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	879	2	here	here	RB
cord-006860-a3b8hyyr	879	3	report	report	VBP
cord-006860-a3b8hyyr	879	4	an	an	DT
cord-006860-a3b8hyyr	879	5	algorhythm	algorhythm	NN
cord-006860-a3b8hyyr	879	6	,	,	,
cord-006860-a3b8hyyr	879	7	by	by	IN
cord-006860-a3b8hyyr	879	8	which	which	WDT
cord-006860-a3b8hyyr	879	9	we	-PRON-	PRP
cord-006860-a3b8hyyr	879	10	use	use	VBP
cord-006860-a3b8hyyr	879	11	an	an	DT
cord-006860-a3b8hyyr	879	12	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	879	13	(	(	-LRB-
cord-006860-a3b8hyyr	879	14	Lupus	lupus	JJ
cord-006860-a3b8hyyr	879	15	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	879	16	)	)	-RRB-
cord-006860-a3b8hyyr	879	17	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	879	18	(	(	-LRB-
cord-006860-a3b8hyyr	879	19	STA	STA	NNP
cord-006860-a3b8hyyr	879	20	APTT	APTT	NNP
cord-006860-a3b8hyyr	879	21	,	,	,
cord-006860-a3b8hyyr	879	22	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	879	23	)	)	-RRB-
cord-006860-a3b8hyyr	879	24	and	and	CC
cord-006860-a3b8hyyr	879	25	an	an	DT
cord-006860-a3b8hyyr	879	26	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	879	27	insensitive	insensitive	JJ
cord-006860-a3b8hyyr	879	28	reagent	reagent	NN
cord-006860-a3b8hyyr	879	29	(	(	-LRB-
cord-006860-a3b8hyyr	879	30	Actin	Actin	NNP
cord-006860-a3b8hyyr	879	31	FS	FS	NNP
cord-006860-a3b8hyyr	879	32	,	,	,
cord-006860-a3b8hyyr	879	33	Dade	Dade	NNP
cord-006860-a3b8hyyr	879	34	)	)	-RRB-
cord-006860-a3b8hyyr	879	35	to	to	TO
cord-006860-a3b8hyyr	879	36	distinguish	distinguish	VB
cord-006860-a3b8hyyr	879	37	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	879	38	and	and	CC
cord-006860-a3b8hyyr	879	39	factor	factor	NN
cord-006860-a3b8hyyr	879	40	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	879	41	as	as	IN
cord-006860-a3b8hyyr	879	42	a	a	DT
cord-006860-a3b8hyyr	879	43	cause	cause	NN
cord-006860-a3b8hyyr	879	44	of	of	IN
cord-006860-a3b8hyyr	879	45	prolonged	prolong	VBN
cord-006860-a3b8hyyr	879	46	aPTT	aptt	NN
cord-006860-a3b8hyyr	879	47	.	.	.
cord-006860-a3b8hyyr	880	1	Citrate	Citrate	NNP
cord-006860-a3b8hyyr	880	2	plasma	plasma	NN
cord-006860-a3b8hyyr	880	3	from	from	IN
cord-006860-a3b8hyyr	880	4	33	33	CD
cord-006860-a3b8hyyr	880	5	patients	patient	NNS
cord-006860-a3b8hyyr	880	6	with	with	IN
cord-006860-a3b8hyyr	880	7	various	various	JJ
cord-006860-a3b8hyyr	880	8	diseases	disease	NNS
cord-006860-a3b8hyyr	880	9	showed	show	VBD
cord-006860-a3b8hyyr	880	10	an	an	DT
cord-006860-a3b8hyyr	880	11	unexpectedly	unexpectedly	RB
cord-006860-a3b8hyyr	880	12	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	880	13	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	880	14	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	880	15	aPTT	aPTT	NNS
cord-006860-a3b8hyyr	880	16	(	(	-LRB-
cord-006860-a3b8hyyr	880	17	>	>	NFP
cord-006860-a3b8hyyr	880	18	40s	40s	CD
cord-006860-a3b8hyyr	880	19	)	)	-RRB-
cord-006860-a3b8hyyr	880	20	.	.	.
cord-006860-a3b8hyyr	881	1	13	13	CD
cord-006860-a3b8hyyr	881	2	plasmas	plasma	NNS
cord-006860-a3b8hyyr	881	3	with	with	IN
cord-006860-a3b8hyyr	881	4	factor	factor	NN
cord-006860-a3b8hyyr	881	5	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	881	6	remained	remain	VBD
cord-006860-a3b8hyyr	881	7	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	881	8	with	with	IN
cord-006860-a3b8hyyr	881	9	the	the	DT
cord-006860-a3b8hyyr	881	10	insensitive	insensitive	JJ
cord-006860-a3b8hyyr	881	11	aPTT	aptt	NN
cord-006860-a3b8hyyr	881	12	reagent	reagent	NN
cord-006860-a3b8hyyr	881	13	.	.	.
cord-006860-a3b8hyyr	882	1	A	a	DT
cord-006860-a3b8hyyr	882	2	regular	regular	JJ
cord-006860-a3b8hyyr	882	3	correction	correction	NN
cord-006860-a3b8hyyr	882	4	of	of	IN
cord-006860-a3b8hyyr	882	5	their	-PRON-	PRP$
cord-006860-a3b8hyyr	882	6	defect	defect	NN
cord-006860-a3b8hyyr	882	7	occured	occur	VBD
cord-006860-a3b8hyyr	882	8	on	on	IN
cord-006860-a3b8hyyr	882	9	mixing	mix	VBG
cord-006860-a3b8hyyr	882	10	with	with	IN
cord-006860-a3b8hyyr	882	11	normal	normal	JJ
cord-006860-a3b8hyyr	882	12	plasma	plasma	NN
cord-006860-a3b8hyyr	882	13	.	.	.
cord-006860-a3b8hyyr	883	1	By	by	IN
cord-006860-a3b8hyyr	883	2	measurement	measurement	NN
cord-006860-a3b8hyyr	883	3	of	of	IN
cord-006860-a3b8hyyr	883	4	single	single	JJ
cord-006860-a3b8hyyr	883	5	coagulation	coagulation	NN
cord-006860-a3b8hyyr	883	6	factors	factor	NNS
cord-006860-a3b8hyyr	883	7	five	five	CD
cord-006860-a3b8hyyr	883	8	patients	patient	NNS
cord-006860-a3b8hyyr	883	9	with	with	IN
cord-006860-a3b8hyyr	883	10	contact	contact	NN
cord-006860-a3b8hyyr	883	11	factor	factor	NN
cord-006860-a3b8hyyr	883	12	XII	XII	NNP
cord-006860-a3b8hyyr	883	13	deficiency	deficiency	NN
cord-006860-a3b8hyyr	883	14	were	be	VBD
cord-006860-a3b8hyyr	883	15	found	find	VBN
cord-006860-a3b8hyyr	883	16	.	.	.
cord-006860-a3b8hyyr	884	1	This	this	DT
cord-006860-a3b8hyyr	884	2	condition	condition	NN
cord-006860-a3b8hyyr	884	3	is	be	VBZ
cord-006860-a3b8hyyr	884	4	associated	associate	VBN
cord-006860-a3b8hyyr	884	5	with	with	IN
cord-006860-a3b8hyyr	884	6	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	884	7	and	and	CC
cord-006860-a3b8hyyr	884	8	very	very	RB
cord-006860-a3b8hyyr	884	9	rarly	rarly	RB
cord-006860-a3b8hyyr	884	10	with	with	IN
cord-006860-a3b8hyyr	884	11	bleeding	bleeding	NN
cord-006860-a3b8hyyr	884	12	.	.	.
cord-006860-a3b8hyyr	885	1	Three	three	CD
cord-006860-a3b8hyyr	885	2	patients	patient	NNS
cord-006860-a3b8hyyr	885	3	with	with	IN
cord-006860-a3b8hyyr	885	4	factor	factor	NN
cord-006860-a3b8hyyr	885	5	XI	XI	NNP
cord-006860-a3b8hyyr	885	6	deficiency	deficiency	NN
cord-006860-a3b8hyyr	885	7	and	and	CC
cord-006860-a3b8hyyr	885	8	two	two	CD
cord-006860-a3b8hyyr	885	9	patient	patient	NN
cord-006860-a3b8hyyr	885	10	with	with	IN
cord-006860-a3b8hyyr	885	11	factor	factor	NN
cord-006860-a3b8hyyr	885	12	IX	IX	NNP
cord-006860-a3b8hyyr	885	13	deficiency	deficiency	NN
cord-006860-a3b8hyyr	885	14	were	be	VBD
cord-006860-a3b8hyyr	885	15	also	also	RB
cord-006860-a3b8hyyr	885	16	identified	identify	VBN
cord-006860-a3b8hyyr	885	17	.	.	.
cord-006860-a3b8hyyr	886	1	Antiplatelets	antiplatelet	NNS
cord-006860-a3b8hyyr	886	2	,	,	,
cord-006860-a3b8hyyr	886	3	of	of	IN
cord-006860-a3b8hyyr	886	4	any	any	DT
cord-006860-a3b8hyyr	886	5	kind	kind	NN
cord-006860-a3b8hyyr	886	6	,	,	,
cord-006860-a3b8hyyr	886	7	permits	permit	VBZ
cord-006860-a3b8hyyr	886	8	a	a	DT
cord-006860-a3b8hyyr	886	9	secondary	secondary	JJ
cord-006860-a3b8hyyr	886	10	prevention	prevention	NN
cord-006860-a3b8hyyr	886	11	of	of	IN
cord-006860-a3b8hyyr	886	12	myocard	myocard	NNP
cord-006860-a3b8hyyr	886	13	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	886	14	lesions	lesion	NNS
cord-006860-a3b8hyyr	886	15	.	.	.
cord-006860-a3b8hyyr	887	1	There	there	EX
cord-006860-a3b8hyyr	887	2	is	be	VBZ
cord-006860-a3b8hyyr	887	3	no	no	DT
cord-006860-a3b8hyyr	887	4	general	general	JJ
cord-006860-a3b8hyyr	887	5	consensus	consensus	NN
cord-006860-a3b8hyyr	887	6	regarding	regard	VBG
cord-006860-a3b8hyyr	887	7	secondary	secondary	JJ
cord-006860-a3b8hyyr	887	8	prevention	prevention	NN
cord-006860-a3b8hyyr	887	9	of	of	IN
cord-006860-a3b8hyyr	887	10	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	887	11	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	887	12	lesions	lesion	NNS
cord-006860-a3b8hyyr	887	13	.	.	.
cord-006860-a3b8hyyr	888	1	Aspirin	aspirin	NN
cord-006860-a3b8hyyr	888	2	remains	remain	VBZ
cord-006860-a3b8hyyr	888	3	the	the	DT
cord-006860-a3b8hyyr	888	4	most	most	RBS
cord-006860-a3b8hyyr	888	5	common	common	JJ
cord-006860-a3b8hyyr	888	6	substance	substance	NN
cord-006860-a3b8hyyr	888	7	,	,	,
cord-006860-a3b8hyyr	888	8	ticlopidlne	ticlopidlne	NNP
cord-006860-a3b8hyyr	888	9	also	also	RB
cord-006860-a3b8hyyr	888	10	brings	bring	VBZ
cord-006860-a3b8hyyr	888	11	about	about	IN
cord-006860-a3b8hyyr	888	12	prevention	prevention	NN
cord-006860-a3b8hyyr	888	13	,	,	,
cord-006860-a3b8hyyr	888	14	but	but	CC
cord-006860-a3b8hyyr	888	15	with	with	IN
cord-006860-a3b8hyyr	888	16	important	important	JJ
cord-006860-a3b8hyyr	888	17	secondary	secondary	JJ
cord-006860-a3b8hyyr	888	18	effects	effect	NNS
cord-006860-a3b8hyyr	888	19	.	.	.
cord-006860-a3b8hyyr	889	1	European	European	NNP
cord-006860-a3b8hyyr	889	2	Stroke	Stroke	NNP
cord-006860-a3b8hyyr	889	3	Prevention	Prevention	NNP
cord-006860-a3b8hyyr	889	4	Study	Study	NNP
cord-006860-a3b8hyyr	890	1	i	i	PRP
cord-006860-a3b8hyyr	890	2	has	have	VBZ
cord-006860-a3b8hyyr	890	3	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	890	4	that	that	IN
cord-006860-a3b8hyyr	890	5	the	the	DT
cord-006860-a3b8hyyr	890	6	combination	combination	NN
cord-006860-a3b8hyyr	890	7	of	of	IN
cord-006860-a3b8hyyr	890	8	antiplatelets	antiplatelet	NNS
cord-006860-a3b8hyyr	890	9	,	,	,
cord-006860-a3b8hyyr	890	10	in	in	IN
cord-006860-a3b8hyyr	890	11	particular	particular	JJ
cord-006860-a3b8hyyr	890	12	aspirin	aspirin	NN
cord-006860-a3b8hyyr	890	13	/	/	SYM
cord-006860-a3b8hyyr	890	14	dipyridamole	dipyridamole	NN
cord-006860-a3b8hyyr	890	15	(	(	-LRB-
cord-006860-a3b8hyyr	890	16	Persantln	Persantln	NNP
cord-006860-a3b8hyyr	890	17	)	)	-RRB-
cord-006860-a3b8hyyr	890	18	,	,	,
cord-006860-a3b8hyyr	890	19	is	be	VBZ
cord-006860-a3b8hyyr	890	20	also	also	RB
cord-006860-a3b8hyyr	890	21	very	very	RB
cord-006860-a3b8hyyr	890	22	active	active	JJ
cord-006860-a3b8hyyr	890	23	.	.	.
cord-006860-a3b8hyyr	891	1	To	to	TO
cord-006860-a3b8hyyr	891	2	collect	collect	VB
cord-006860-a3b8hyyr	891	3	more	more	JJR
cord-006860-a3b8hyyr	891	4	information	information	NN
cord-006860-a3b8hyyr	891	5	,	,	,
cord-006860-a3b8hyyr	891	6	ESPS	ESPS	NNP
cord-006860-a3b8hyyr	891	7	2	2	CD
cord-006860-a3b8hyyr	891	8	was	be	VBD
cord-006860-a3b8hyyr	891	9	organized	organize	VBN
cord-006860-a3b8hyyr	891	10	and	and	CC
cord-006860-a3b8hyyr	891	11	6602	6602	CD
cord-006860-a3b8hyyr	891	12	patients	patient	NNS
cord-006860-a3b8hyyr	891	13	receiving	receive	VBG
cord-006860-a3b8hyyr	891	14	either	either	CC
cord-006860-a3b8hyyr	891	15	a	a	DT
cord-006860-a3b8hyyr	891	16	placebo	placebo	NN
cord-006860-a3b8hyyr	891	17	,	,	,
cord-006860-a3b8hyyr	891	18	either	either	CC
cord-006860-a3b8hyyr	891	19	50	50	CD
cord-006860-a3b8hyyr	891	20	mg	mg	NNP
cord-006860-a3b8hyyr	891	21	aspirin	aspirin	NN
cord-006860-a3b8hyyr	891	22	,	,	,
cord-006860-a3b8hyyr	891	23	either	either	CC
cord-006860-a3b8hyyr	891	24	400	400	CD
cord-006860-a3b8hyyr	891	25	mg	mg	NNS
cord-006860-a3b8hyyr	891	26	sustained	sustain	VBD
cord-006860-a3b8hyyr	891	27	release	release	NN
cord-006860-a3b8hyyr	891	28	form	form	NN
cord-006860-a3b8hyyr	891	29	of	of	IN
cord-006860-a3b8hyyr	891	30	dipyridamole	dipyridamole	NN
cord-006860-a3b8hyyr	892	1	(	(	-LRB-
cord-006860-a3b8hyyr	892	2	Persantin	Persantin	NNP
cord-006860-a3b8hyyr	892	3	(	(	-LRB-
cord-006860-a3b8hyyr	892	4	R	r	NN
cord-006860-a3b8hyyr	892	5	)	)	-RRB-
cord-006860-a3b8hyyr	892	6	)	)	-RRB-
cord-006860-a3b8hyyr	892	7	,	,	,
cord-006860-a3b8hyyr	892	8	or	or	CC
cord-006860-a3b8hyyr	892	9	the	the	DT
cord-006860-a3b8hyyr	892	10	combination	combination	NN
cord-006860-a3b8hyyr	892	11	aspirin	aspirin	NN
cord-006860-a3b8hyyr	892	12	/	/	SYM
cord-006860-a3b8hyyr	892	13	dipyrldamole	dipyrldamole	NNP
cord-006860-a3b8hyyr	892	14	,	,	,
cord-006860-a3b8hyyr	892	15	were	be	VBD
cord-006860-a3b8hyyr	892	16	recruited	recruit	VBN
cord-006860-a3b8hyyr	892	17	.	.	.
cord-006860-a3b8hyyr	893	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	893	2	ended	end	VBD
cord-006860-a3b8hyyr	893	3	March	March	NNP
cord-006860-a3b8hyyr	893	4	31st	31st	NN
cord-006860-a3b8hyyr	893	5	1995	1995	CD
cord-006860-a3b8hyyr	893	6	with	with	IN
cord-006860-a3b8hyyr	893	7	the	the	DT
cord-006860-a3b8hyyr	893	8	following	follow	VBG
cord-006860-a3b8hyyr	893	9	conclusions	conclusion	NNS
cord-006860-a3b8hyyr	893	10	:	:	:
cord-006860-a3b8hyyr	893	11	I	i	NN
cord-006860-a3b8hyyr	893	12	-	-	HYPH
cord-006860-a3b8hyyr	893	13	aspirin	aspirin	NN
cord-006860-a3b8hyyr	893	14	,	,	,
cord-006860-a3b8hyyr	893	15	50	50	CD
cord-006860-a3b8hyyr	893	16	mg	mg	NNS
cord-006860-a3b8hyyr	893	17	a	a	DT
cord-006860-a3b8hyyr	893	18	day	day	NN
cord-006860-a3b8hyyr	893	19	,	,	,
cord-006860-a3b8hyyr	893	20	brings	bring	VBZ
cord-006860-a3b8hyyr	893	21	about	about	RP
cord-006860-a3b8hyyr	893	22	a	a	DT
cord-006860-a3b8hyyr	893	23	significant	significant	JJ
cord-006860-a3b8hyyr	893	24	secondary	secondary	JJ
cord-006860-a3b8hyyr	893	25	reduction	reduction	NN
cord-006860-a3b8hyyr	893	26	of	of	IN
cord-006860-a3b8hyyr	893	27	stroke	stroke	NN
cord-006860-a3b8hyyr	893	28	(	(	-LRB-
cord-006860-a3b8hyyr	893	29	18.Z	18.z	CD
cord-006860-a3b8hyyr	893	30	%	%	NN
cord-006860-a3b8hyyr	893	31	)	)	-RRB-
cord-006860-a3b8hyyr	893	32	,	,	,
cord-006860-a3b8hyyr	893	33	after	after	IN
cord-006860-a3b8hyyr	893	34	a	a	DT
cord-006860-a3b8hyyr	893	35	two	two	CD
cord-006860-a3b8hyyr	893	36	year	year	NN
cord-006860-a3b8hyyr	893	37	follow	follow	NN
cord-006860-a3b8hyyr	893	38	-	-	HYPH
cord-006860-a3b8hyyr	893	39	up	up	NN
cord-006860-a3b8hyyr	893	40	.	.	.
cord-006860-a3b8hyyr	894	1	Notwithstanding	notwithstanding	IN
cord-006860-a3b8hyyr	894	2	the	the	DT
cord-006860-a3b8hyyr	894	3	low	low	JJ
cord-006860-a3b8hyyr	894	4	dose	dose	NN
cord-006860-a3b8hyyr	894	5	of	of	IN
cord-006860-a3b8hyyr	894	6	aspirin	aspirin	NN
cord-006860-a3b8hyyr	894	7	,	,	,
cord-006860-a3b8hyyr	894	8	haemorrhages	haemorrhage	NNS
cord-006860-a3b8hyyr	894	9	remain	remain	VBP
cord-006860-a3b8hyyr	894	10	important	important	JJ
cord-006860-a3b8hyyr	894	11	.	.	.
cord-006860-a3b8hyyr	895	1	2-dipyridamole	2-dipyridamole	CD
cord-006860-a3b8hyyr	895	2	,	,	,
cord-006860-a3b8hyyr	895	3	at	at	IN
cord-006860-a3b8hyyr	895	4	400	400	CD
cord-006860-a3b8hyyr	895	5	mg	mg	NNS
cord-006860-a3b8hyyr	895	6	a	a	DT
cord-006860-a3b8hyyr	895	7	day	day	NN
cord-006860-a3b8hyyr	895	8	,	,	,
cord-006860-a3b8hyyr	895	9	brings	bring	VBZ
cord-006860-a3b8hyyr	895	10	about	about	RP
cord-006860-a3b8hyyr	895	11	a	a	DT
cord-006860-a3b8hyyr	895	12	significant	significant	JJ
cord-006860-a3b8hyyr	895	13	reduction	reduction	NN
cord-006860-a3b8hyyr	895	14	of	of	IN
cord-006860-a3b8hyyr	895	15	stroke	stroke	NN
cord-006860-a3b8hyyr	895	16	(	(	-LRB-
cord-006860-a3b8hyyr	895	17	i6.3~	i6.3~	NNP
cord-006860-a3b8hyyr	895	18	)	)	-RRB-
cord-006860-a3b8hyyr	895	19	,	,	,
cord-006860-a3b8hyyr	895	20	similar	similar	JJ
cord-006860-a3b8hyyr	895	21	to	to	IN
cord-006860-a3b8hyyr	895	22	that	that	DT
cord-006860-a3b8hyyr	895	23	of	of	IN
cord-006860-a3b8hyyr	895	24	aspirin	aspirin	NN
cord-006860-a3b8hyyr	895	25	.	.	.
cord-006860-a3b8hyyr	896	1	One	one	PRP
cord-006860-a3b8hyyr	896	2	could	could	MD
cord-006860-a3b8hyyr	896	3	thus	thus	RB
cord-006860-a3b8hyyr	896	4	substitute	substitute	VB
cord-006860-a3b8hyyr	896	5	50	50	CD
cord-006860-a3b8hyyr	896	6	mg	mg	NN
cord-006860-a3b8hyyr	897	1	aspirin	aspirin	NN
cord-006860-a3b8hyyr	897	2	by	by	IN
cord-006860-a3b8hyyr	897	3	400	400	CD
cord-006860-a3b8hyyr	897	4	mg	mg	NNP
cord-006860-a3b8hyyr	897	5	dipyridamole	dipyridamole	NN
cord-006860-a3b8hyyr	897	6	.	.	.
cord-006860-a3b8hyyr	898	1	3-the	3-the	JJ
cord-006860-a3b8hyyr	898	2	combination	combination	NN
cord-006860-a3b8hyyr	898	3	of	of	IN
cord-006860-a3b8hyyr	898	4	50	50	CD
cord-006860-a3b8hyyr	898	5	mg	mg	NN
cord-006860-a3b8hyyr	898	6	aspirin	aspirin	NN
cord-006860-a3b8hyyr	898	7	and	and	CC
cord-006860-a3b8hyyr	898	8	400	400	CD
cord-006860-a3b8hyyr	898	9	mg	mg	NN
cord-006860-a3b8hyyr	898	10	dipyridamole	dipyridamole	NN
cord-006860-a3b8hyyr	898	11	brings	bring	VBZ
cord-006860-a3b8hyyr	898	12	about	about	RP
cord-006860-a3b8hyyr	898	13	a	a	DT
cord-006860-a3b8hyyr	898	14	significantly	significantly	RB
cord-006860-a3b8hyyr	898	15	greater	great	JJR
cord-006860-a3b8hyyr	898	16	reduction	reduction	NN
cord-006860-a3b8hyyr	898	17	of	of	IN
cord-006860-a3b8hyyr	898	18	stroke	stroke	NN
cord-006860-a3b8hyyr	898	19	(	(	-LRB-
cord-006860-a3b8hyyr	898	20	37.0	37.0	CD
cord-006860-a3b8hyyr	898	21	~	~	NFP
cord-006860-a3b8hyyr	898	22	)	)	-RRB-
cord-006860-a3b8hyyr	898	23	.	.	.
cord-006860-a3b8hyyr	899	1	ESPS	ESPS	NNP
cord-006860-a3b8hyyr	899	2	2	2	CD
cord-006860-a3b8hyyr	899	3	revealed	reveal	VBD
cord-006860-a3b8hyyr	899	4	that	that	IN
cord-006860-a3b8hyyr	899	5	a	a	DT
cord-006860-a3b8hyyr	899	6	low	low	JJ
cord-006860-a3b8hyyr	899	7	dosage	dosage	NN
cord-006860-a3b8hyyr	899	8	of	of	IN
cord-006860-a3b8hyyr	899	9	aspirin	aspirin	NN
cord-006860-a3b8hyyr	899	10	is	be	VBZ
cord-006860-a3b8hyyr	899	11	active	active	JJ
cord-006860-a3b8hyyr	899	12	,	,	,
cord-006860-a3b8hyyr	899	13	that	that	DT
cord-006860-a3b8hyyr	899	14	dipyridamole	dipyridamole	NNP
cord-006860-a3b8hyyr	899	15	alone	alone	RB
cord-006860-a3b8hyyr	899	16	is	be	VBZ
cord-006860-a3b8hyyr	899	17	also	also	RB
cord-006860-a3b8hyyr	899	18	active	active	JJ
cord-006860-a3b8hyyr	899	19	,	,	,
cord-006860-a3b8hyyr	899	20	but	but	CC
cord-006860-a3b8hyyr	899	21	that	that	IN
cord-006860-a3b8hyyr	899	22	the	the	DT
cord-006860-a3b8hyyr	899	23	combination	combination	NN
cord-006860-a3b8hyyr	899	24	of	of	IN
cord-006860-a3b8hyyr	899	25	both	both	DT
cord-006860-a3b8hyyr	899	26	gives	give	VBZ
cord-006860-a3b8hyyr	899	27	far	far	RB
cord-006860-a3b8hyyr	899	28	better	well	JJR
cord-006860-a3b8hyyr	899	29	results	result	NNS
cord-006860-a3b8hyyr	899	30	.	.	.
cord-006860-a3b8hyyr	900	1	The	the	DT
cord-006860-a3b8hyyr	900	2	study	study	NN
cord-006860-a3b8hyyr	900	3	of	of	IN
cord-006860-a3b8hyyr	900	4	the	the	DT
cord-006860-a3b8hyyr	900	5	primary	primary	JJ
cord-006860-a3b8hyyr	900	6	end	end	NN
cord-006860-a3b8hyyr	900	7	-	-	HYPH
cord-006860-a3b8hyyr	900	8	points	point	NNS
cord-006860-a3b8hyyr	900	9	,	,	,
cord-006860-a3b8hyyr	900	10	the	the	DT
cord-006860-a3b8hyyr	900	11	study	study	NN
cord-006860-a3b8hyyr	900	12	of	of	IN
cord-006860-a3b8hyyr	900	13	the	the	DT
cord-006860-a3b8hyyr	900	14	survival	survival	NN
cord-006860-a3b8hyyr	900	15	curves	curve	NNS
cord-006860-a3b8hyyr	900	16	,	,	,
cord-006860-a3b8hyyr	900	17	the	the	DT
cord-006860-a3b8hyyr	900	18	factorial	factorial	JJ
cord-006860-a3b8hyyr	900	19	statistical	statistical	JJ
cord-006860-a3b8hyyr	900	20	analysis	analysis	NN
cord-006860-a3b8hyyr	900	21	and	and	CC
cord-006860-a3b8hyyr	900	22	the	the	DT
cord-006860-a3b8hyyr	900	23	pairwise	pairwise	JJ
cord-006860-a3b8hyyr	900	24	comparison	comparison	NN
cord-006860-a3b8hyyr	900	25	analysis	analysis	NN
cord-006860-a3b8hyyr	900	26	,	,	,
cord-006860-a3b8hyyr	900	27	led	lead	VBD
cord-006860-a3b8hyyr	900	28	to	to	IN
cord-006860-a3b8hyyr	900	29	these	these	DT
cord-006860-a3b8hyyr	900	30	conclusions	conclusion	NNS
cord-006860-a3b8hyyr	900	31	.	.	.
cord-006860-a3b8hyyr	901	1	The	the	DT
cord-006860-a3b8hyyr	901	2	conclusions	conclusion	NNS
cord-006860-a3b8hyyr	901	3	drawn	draw	VBN
cord-006860-a3b8hyyr	901	4	from	from	IN
cord-006860-a3b8hyyr	901	5	ESP£	ESP£	NNP
cord-006860-a3b8hyyr	901	6	2	2	CD
cord-006860-a3b8hyyr	901	7	underline	underline	VBP
cord-006860-a3b8hyyr	901	8	that	that	IN
cord-006860-a3b8hyyr	901	9	the	the	DT
cord-006860-a3b8hyyr	901	10	combination	combination	NN
cord-006860-a3b8hyyr	901	11	aspirin	aspirin	NN
cord-006860-a3b8hyyr	901	12	/	/	SYM
cord-006860-a3b8hyyr	901	13	dipyridamole	dipyridamole	NN
cord-006860-a3b8hyyr	901	14	is	be	VBZ
cord-006860-a3b8hyyr	901	15	a	a	DT
cord-006860-a3b8hyyr	901	16	privileged	privileged	JJ
cord-006860-a3b8hyyr	901	17	choice	choice	NN
cord-006860-a3b8hyyr	901	18	for	for	IN
cord-006860-a3b8hyyr	901	19	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	901	20	ischemia	ischemia	NN
cord-006860-a3b8hyyr	901	21	,	,	,
cord-006860-a3b8hyyr	901	22	The	the	DT
cord-006860-a3b8hyyr	901	23	state	state	NN
cord-006860-a3b8hyyr	901	24	of	of	IN
cord-006860-a3b8hyyr	901	25	activation	activation	NN
cord-006860-a3b8hyyr	901	26	of	of	IN
cord-006860-a3b8hyyr	901	27	circulating	circulate	VBG
cord-006860-a3b8hyyr	901	28	platelets	platelet	NNS
cord-006860-a3b8hyyr	901	29	in	in	IN
cord-006860-a3b8hyyr	901	30	acute	acute	JJ
cord-006860-a3b8hyyr	901	31	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	901	32	ischemia	ischemia	NN
cord-006860-a3b8hyyr	901	33	is	be	VBZ
cord-006860-a3b8hyyr	901	34	controversial	controversial	JJ
cord-006860-a3b8hyyr	901	35	.	.	.
cord-006860-a3b8hyyr	902	1	Activation	activation	NN
cord-006860-a3b8hyyr	902	2	of	of	IN
cord-006860-a3b8hyyr	902	3	platelets	platelet	NNS
cord-006860-a3b8hyyr	902	4	on	on	IN
cord-006860-a3b8hyyr	902	5	single	single	JJ
cord-006860-a3b8hyyr	902	6	cell	cell	NN
cord-006860-a3b8hyyr	902	7	level	level	NN
cord-006860-a3b8hyyr	902	8	can	can	MD
cord-006860-a3b8hyyr	902	9	be	be	VB
cord-006860-a3b8hyyr	902	10	assessed	assess	VBN
cord-006860-a3b8hyyr	902	11	by	by	IN
cord-006860-a3b8hyyr	902	12	determining	determine	VBG
cord-006860-a3b8hyyr	902	13	the	the	DT
cord-006860-a3b8hyyr	902	14	shape	shape	NN
cord-006860-a3b8hyyr	902	15	change	change	NN
cord-006860-a3b8hyyr	902	16	or	or	CC
cord-006860-a3b8hyyr	902	17	the	the	DT
cord-006860-a3b8hyyr	902	18	expression	expression	NN
cord-006860-a3b8hyyr	902	19	of	of	IN
cord-006860-a3b8hyyr	902	20	antigens	antigen	NNS
cord-006860-a3b8hyyr	902	21	such	such	JJ
cord-006860-a3b8hyyr	902	22	as	as	IN
cord-006860-a3b8hyyr	902	23	p	p	NN
cord-006860-a3b8hyyr	902	24	-	-	:
cord-006860-a3b8hyyr	902	25	selectin	selectin	NNP
cord-006860-a3b8hyyr	902	26	(	(	-LRB-
cord-006860-a3b8hyyr	902	27	CD62	CD62	NNP
cord-006860-a3b8hyyr	902	28	)	)	-RRB-
cord-006860-a3b8hyyr	902	29	.	.	.
cord-006860-a3b8hyyr	903	1	Shape	shape	NN
cord-006860-a3b8hyyr	903	2	change	change	NN
cord-006860-a3b8hyyr	903	3	is	be	VBZ
cord-006860-a3b8hyyr	903	4	an	an	DT
cord-006860-a3b8hyyr	903	5	early	early	JJ
cord-006860-a3b8hyyr	903	6	and	and	CC
cord-006860-a3b8hyyr	903	7	rapidly	rapidly	RB
cord-006860-a3b8hyyr	903	8	reversible	reversible	JJ
cord-006860-a3b8hyyr	903	9	event	event	NN
cord-006860-a3b8hyyr	903	10	in	in	IN
cord-006860-a3b8hyyr	903	11	platelet	platelet	NN
cord-006860-a3b8hyyr	903	12	activation	activation	NN
cord-006860-a3b8hyyr	903	13	whereas	whereas	IN
cord-006860-a3b8hyyr	903	14	p	p	NN
cord-006860-a3b8hyyr	903	15	-	-	:
cord-006860-a3b8hyyr	903	16	selectin	selectin	NNP
cord-006860-a3b8hyyr	903	17	is	be	VBZ
cord-006860-a3b8hyyr	903	18	irreversibly	irreversibly	RB
cord-006860-a3b8hyyr	903	19	expressed	express	VBN
cord-006860-a3b8hyyr	903	20	on	on	IN
cord-006860-a3b8hyyr	903	21	the	the	DT
cord-006860-a3b8hyyr	903	22	platelet	platelet	NN
cord-006860-a3b8hyyr	903	23	surface	surface	NN
cord-006860-a3b8hyyr	903	24	upon	upon	IN
cord-006860-a3b8hyyr	903	25	stimulation	stimulation	NN
cord-006860-a3b8hyyr	903	26	.	.	.
cord-006860-a3b8hyyr	904	1	Methods	method	NNS
cord-006860-a3b8hyyr	904	2	:	:	:
cord-006860-a3b8hyyr	904	3	We	-PRON-	PRP
cord-006860-a3b8hyyr	904	4	investigated	investigate	VBD
cord-006860-a3b8hyyr	904	5	20	20	CD
cord-006860-a3b8hyyr	904	6	untreated	untreated	JJ
cord-006860-a3b8hyyr	904	7	patients	patient	NNS
cord-006860-a3b8hyyr	904	8	within	within	IN
cord-006860-a3b8hyyr	904	9	one	one	CD
cord-006860-a3b8hyyr	904	10	day	day	NN
cord-006860-a3b8hyyr	904	11	after	after	IN
cord-006860-a3b8hyyr	904	12	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	904	13	ischemia	ischemia	NN
cord-006860-a3b8hyyr	904	14	,	,	,
cord-006860-a3b8hyyr	904	15	20	20	CD
cord-006860-a3b8hyyr	904	16	patients	patient	NNS
cord-006860-a3b8hyyr	904	17	months	month	NNS
cord-006860-a3b8hyyr	904	18	after	after	IN
cord-006860-a3b8hyyr	904	19	stroke	stroke	NN
cord-006860-a3b8hyyr	904	20	treated	treat	VBN
cord-006860-a3b8hyyr	904	21	with	with	IN
cord-006860-a3b8hyyr	904	22	warfarin	warfarin	NN
cord-006860-a3b8hyyr	904	23	,	,	,
cord-006860-a3b8hyyr	904	24	and	and	CC
cord-006860-a3b8hyyr	904	25	21	21	CD
cord-006860-a3b8hyyr	904	26	age	age	NN
cord-006860-a3b8hyyr	904	27	and	and	CC
cord-006860-a3b8hyyr	904	28	sex	sex	NN
cord-006860-a3b8hyyr	904	29	matched	match	VBN
cord-006860-a3b8hyyr	904	30	control	control	NN
cord-006860-a3b8hyyr	904	31	subjects	subject	NNS
cord-006860-a3b8hyyr	904	32	without	without	IN
cord-006860-a3b8hyyr	904	33	vascular	vascular	JJ
cord-006860-a3b8hyyr	904	34	risk	risk	NN
cord-006860-a3b8hyyr	904	35	factors	factor	NNS
cord-006860-a3b8hyyr	904	36	.	.	.
cord-006860-a3b8hyyr	905	1	Venous	venous	JJ
cord-006860-a3b8hyyr	905	2	blood	blood	NN
cord-006860-a3b8hyyr	905	3	was	be	VBD
cord-006860-a3b8hyyr	905	4	collected	collect	VBN
cord-006860-a3b8hyyr	905	5	into	into	IN
cord-006860-a3b8hyyr	905	6	a	a	DT
cord-006860-a3b8hyyr	905	7	fixation	fixation	NN
cord-006860-a3b8hyyr	905	8	solution	solution	NN
cord-006860-a3b8hyyr	905	9	blocking	block	VBG
cord-006860-a3b8hyyr	905	10	the	the	DT
cord-006860-a3b8hyyr	905	11	metabolic	metabolic	JJ
cord-006860-a3b8hyyr	905	12	processes	process	NNS
cord-006860-a3b8hyyr	905	13	in	in	IN
cord-006860-a3b8hyyr	905	14	platelets	platelet	NNS
cord-006860-a3b8hyyr	905	15	within	within	IN
cord-006860-a3b8hyyr	905	16	milliseconds	millisecond	NNS
cord-006860-a3b8hyyr	905	17	.	.	.
cord-006860-a3b8hyyr	906	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	906	2	determined	determine	VBD
cord-006860-a3b8hyyr	906	3	the	the	DT
cord-006860-a3b8hyyr	906	4	fraction	fraction	NN
cord-006860-a3b8hyyr	906	5	of	of	IN
cord-006860-a3b8hyyr	906	6	resting	rest	VBG
cord-006860-a3b8hyyr	906	7	discoid	discoid	JJ
cord-006860-a3b8hyyr	906	8	platelets	platelet	NNS
cord-006860-a3b8hyyr	906	9	by	by	IN
cord-006860-a3b8hyyr	906	10	phase	phase	NN
cord-006860-a3b8hyyr	906	11	contrast	contrast	NN
cord-006860-a3b8hyyr	906	12	microscopy	microscopy	NN
cord-006860-a3b8hyyr	906	13	.	.	.
cord-006860-a3b8hyyr	907	1	The	the	DT
cord-006860-a3b8hyyr	907	2	expression	expression	NN
cord-006860-a3b8hyyr	907	3	of	of	IN
cord-006860-a3b8hyyr	907	4	p	p	NN
cord-006860-a3b8hyyr	907	5	-	-	:
cord-006860-a3b8hyyr	907	6	selectin	selectin	NNP
cord-006860-a3b8hyyr	907	7	was	be	VBD
cord-006860-a3b8hyyr	907	8	measured	measure	VBN
cord-006860-a3b8hyyr	907	9	by	by	IN
cord-006860-a3b8hyyr	907	10	flowcytometry	flowcytometry	NNP
cord-006860-a3b8hyyr	907	11	.	.	.
cord-006860-a3b8hyyr	908	1	Results	result	NNS
cord-006860-a3b8hyyr	908	2	:	:	:
cord-006860-a3b8hyyr	909	1	The	the	DT
cord-006860-a3b8hyyr	909	2	fraction	fraction	NN
cord-006860-a3b8hyyr	909	3	of	of	IN
cord-006860-a3b8hyyr	909	4	platelets	platelet	NNS
cord-006860-a3b8hyyr	909	5	expressing	express	VBG
cord-006860-a3b8hyyr	909	6	p	p	NN
cord-006860-a3b8hyyr	909	7	-	-	:
cord-006860-a3b8hyyr	909	8	selectin	selectin	NNP
cord-006860-a3b8hyyr	909	9	was	be	VBD
cord-006860-a3b8hyyr	909	10	higher	high	JJR
cord-006860-a3b8hyyr	909	11	in	in	IN
cord-006860-a3b8hyyr	909	12	patients	patient	NNS
cord-006860-a3b8hyyr	909	13	with	with	IN
cord-006860-a3b8hyyr	909	14	acute	acute	JJ
cord-006860-a3b8hyyr	909	15	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	909	16	ischemia	ischemia	NN
cord-006860-a3b8hyyr	909	17	(	(	-LRB-
cord-006860-a3b8hyyr	909	18	7.8_+4.7	7.8_+4.7	CD
cord-006860-a3b8hyyr	909	19	%	%	NN
cord-006860-a3b8hyyr	909	20	)	)	-RRB-
cord-006860-a3b8hyyr	909	21	than	than	IN
cord-006860-a3b8hyyr	909	22	in	in	IN
cord-006860-a3b8hyyr	909	23	control	control	NN
cord-006860-a3b8hyyr	909	24	subjects	subject	NNS
cord-006860-a3b8hyyr	909	25	(	(	-LRB-
cord-006860-a3b8hyyr	909	26	1.9_+1.1	1.9_+1.1	CD
cord-006860-a3b8hyyr	909	27	%	%	NN
cord-006860-a3b8hyyr	909	28	;	;	,
cord-006860-a3b8hyyr	909	29	p<0.001	p<0.001	CD
cord-006860-a3b8hyyr	909	30	,	,	,
cord-006860-a3b8hyyr	909	31	u	u	NN
cord-006860-a3b8hyyr	909	32	-	-	HYPH
cord-006860-a3b8hyyr	909	33	test	test	NN
cord-006860-a3b8hyyr	909	34	)	)	-RRB-
cord-006860-a3b8hyyr	909	35	.	.	.
cord-006860-a3b8hyyr	910	1	Patients	patient	NNS
cord-006860-a3b8hyyr	910	2	with	with	IN
cord-006860-a3b8hyyr	910	3	stroke	stroke	NN
cord-006860-a3b8hyyr	910	4	(	(	-LRB-
cord-006860-a3b8hyyr	910	5	n=15	n=15	NNP
cord-006860-a3b8hyyr	910	6	,	,	,
cord-006860-a3b8hyyr	910	7	7.8	7.8	CD
cord-006860-a3b8hyyr	910	8	+	+	SYM
cord-006860-a3b8hyyr	910	9	4.5	4.5	CD
cord-006860-a3b8hyyr	910	10	%	%	NN
cord-006860-a3b8hyyr	910	11	)	)	-RRB-
cord-006860-a3b8hyyr	910	12	and	and	CC
cord-006860-a3b8hyyr	910	13	patients	patient	NNS
cord-006860-a3b8hyyr	910	14	with	with	IN
cord-006860-a3b8hyyr	910	15	transient	transient	JJ
cord-006860-a3b8hyyr	910	16	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	910	17	attack	attack	NN
cord-006860-a3b8hyyr	910	18	(	(	-LRB-
cord-006860-a3b8hyyr	910	19	TIA	TIA	NNP
cord-006860-a3b8hyyr	910	20	;	;	:
cord-006860-a3b8hyyr	910	21	n=5	n=5	JJ
cord-006860-a3b8hyyr	910	22	,	,	,
cord-006860-a3b8hyyr	910	23	7.6-+6.1	7.6-+6.1	CD
cord-006860-a3b8hyyr	910	24	%	%	NN
cord-006860-a3b8hyyr	910	25	)	)	-RRB-
cord-006860-a3b8hyyr	910	26	had	have	VBD
cord-006860-a3b8hyyr	910	27	similar	similar	JJ
cord-006860-a3b8hyyr	910	28	values	value	NNS
cord-006860-a3b8hyyr	910	29	.	.	.
cord-006860-a3b8hyyr	911	1	Patients	patient	NNS
cord-006860-a3b8hyyr	911	2	months	month	NNS
cord-006860-a3b8hyyr	911	3	after	after	IN
cord-006860-a3b8hyyr	911	4	stroke	stroke	NN
cord-006860-a3b8hyyr	911	5	still	still	RB
cord-006860-a3b8hyyr	911	6	had	have	VBD
cord-006860-a3b8hyyr	911	7	higher	high	JJR
cord-006860-a3b8hyyr	911	8	values	value	NNS
cord-006860-a3b8hyyr	911	9	(	(	-LRB-
cord-006860-a3b8hyyr	911	10	4.3	4.3	CD
cord-006860-a3b8hyyr	911	11	+	+	SYM
cord-006860-a3b8hyyr	911	12	9,3	9,3	CD
cord-006860-a3b8hyyr	911	13	%	%	NN
cord-006860-a3b8hyyr	911	14	,	,	,
cord-006860-a3b8hyyr	911	15	p<0.05	p<0.05	CD
cord-006860-a3b8hyyr	911	16	)	)	-RRB-
cord-006860-a3b8hyyr	911	17	than	than	IN
cord-006860-a3b8hyyr	911	18	control	control	NN
cord-006860-a3b8hyyr	911	19	subjects	subject	NNS
cord-006860-a3b8hyyr	911	20	.	.	.
cord-006860-a3b8hyyr	912	1	The	the	DT
cord-006860-a3b8hyyr	912	2	rate	rate	NN
cord-006860-a3b8hyyr	912	3	of	of	IN
cord-006860-a3b8hyyr	912	4	discoid	discoid	JJ
cord-006860-a3b8hyyr	912	5	platelets	platelet	NNS
cord-006860-a3b8hyyr	912	6	was	be	VBD
cord-006860-a3b8hyyr	912	7	not	not	RB
cord-006860-a3b8hyyr	912	8	different	different	JJ
cord-006860-a3b8hyyr	912	9	between	between	IN
cord-006860-a3b8hyyr	912	10	patients	patient	NNS
cord-006860-a3b8hyyr	912	11	with	with	IN
cord-006860-a3b8hyyr	912	12	acute	acute	JJ
cord-006860-a3b8hyyr	912	13	ischemia	ischemia	NN
cord-006860-a3b8hyyr	912	14	(	(	-LRB-
cord-006860-a3b8hyyr	912	15	n=17	n=17	NNP
cord-006860-a3b8hyyr	912	16	,	,	,
cord-006860-a3b8hyyr	912	17	85.6-+8.8	85.6-+8.8	CD
cord-006860-a3b8hyyr	912	18	%	%	NN
cord-006860-a3b8hyyr	912	19	)	)	-RRB-
cord-006860-a3b8hyyr	912	20	,	,	,
cord-006860-a3b8hyyr	912	21	patients	patient	NNS
cord-006860-a3b8hyyr	912	22	months	month	NNS
cord-006860-a3b8hyyr	912	23	after	after	IN
cord-006860-a3b8hyyr	912	24	stroke	stroke	NN
cord-006860-a3b8hyyr	912	25	(	(	-LRB-
cord-006860-a3b8hyyr	912	26	n=19	n=19	JJ
cord-006860-a3b8hyyr	912	27	,	,	,
cord-006860-a3b8hyyr	912	28	85.7-+5.1	85.7-+5.1	CD
cord-006860-a3b8hyyr	912	29	%	%	NN
cord-006860-a3b8hyyr	912	30	)	)	-RRB-
cord-006860-a3b8hyyr	912	31	and	and	CC
cord-006860-a3b8hyyr	912	32	control	control	NN
cord-006860-a3b8hyyr	912	33	subjects	subject	NNS
cord-006860-a3b8hyyr	912	34	(	(	-LRB-
cord-006860-a3b8hyyr	912	35	n=21	n=21	NNP
cord-006860-a3b8hyyr	912	36	,	,	,
cord-006860-a3b8hyyr	912	37	86.7_+5.8	86.7_+5.8	CD
cord-006860-a3b8hyyr	912	38	%	%	NN
cord-006860-a3b8hyyr	912	39	)	)	-RRB-
cord-006860-a3b8hyyr	912	40	.	.	.
cord-006860-a3b8hyyr	913	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	913	2	count	count	NN
cord-006860-a3b8hyyr	913	3	was	be	VBD
cord-006860-a3b8hyyr	913	4	not	not	RB
cord-006860-a3b8hyyr	913	5	significantly	significantly	RB
cord-006860-a3b8hyyr	913	6	different	different	JJ
cord-006860-a3b8hyyr	913	7	between	between	IN
cord-006860-a3b8hyyr	913	8	groups	group	NNS
cord-006860-a3b8hyyr	913	9	.	.	.
cord-006860-a3b8hyyr	914	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	914	2	:	:	:
cord-006860-a3b8hyyr	915	1	The	the	DT
cord-006860-a3b8hyyr	915	2	elevated	elevated	JJ
cord-006860-a3b8hyyr	915	3	proportion	proportion	NN
cord-006860-a3b8hyyr	915	4	of	of	IN
cord-006860-a3b8hyyr	915	5	platelets	platelet	NNS
cord-006860-a3b8hyyr	915	6	expressing	express	VBG
cord-006860-a3b8hyyr	915	7	pselectin	pselectin	NNP
cord-006860-a3b8hyyr	915	8	indicates	indicate	VBZ
cord-006860-a3b8hyyr	915	9	strong	strong	JJ
cord-006860-a3b8hyyr	915	10	platelet	platelet	NN
cord-006860-a3b8hyyr	915	11	activation	activation	NN
cord-006860-a3b8hyyr	915	12	in	in	IN
cord-006860-a3b8hyyr	915	13	acute	acute	JJ
cord-006860-a3b8hyyr	915	14	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	915	15	ischemia	ischemia	NN
cord-006860-a3b8hyyr	915	16	and	and	CC
cord-006860-a3b8hyyr	915	17	in	in	IN
cord-006860-a3b8hyyr	915	18	a	a	DT
cord-006860-a3b8hyyr	915	19	majority	majority	NN
cord-006860-a3b8hyyr	915	20	of	of	IN
cord-006860-a3b8hyyr	915	21	patients	patient	NNS
cord-006860-a3b8hyyr	915	22	months	month	NNS
cord-006860-a3b8hyyr	915	23	after	after	IN
cord-006860-a3b8hyyr	915	24	stroke	stroke	NN
cord-006860-a3b8hyyr	915	25	.	.	.
cord-006860-a3b8hyyr	916	1	Assessment	assessment	NN
cord-006860-a3b8hyyr	916	2	of	of	IN
cord-006860-a3b8hyyr	916	3	pselectin	pselectin	NNP
cord-006860-a3b8hyyr	916	4	revealed	reveal	VBD
cord-006860-a3b8hyyr	916	5	a	a	DT
cord-006860-a3b8hyyr	916	6	higher	high	JJR
cord-006860-a3b8hyyr	916	7	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	916	8	for	for	IN
cord-006860-a3b8hyyr	916	9	platelet	platelet	NN
cord-006860-a3b8hyyr	916	10	activation	activation	NN
cord-006860-a3b8hyyr	916	11	after	after	IN
cord-006860-a3b8hyyr	916	12	stroke	stroke	NN
cord-006860-a3b8hyyr	916	13	or	or	CC
cord-006860-a3b8hyyr	916	14	TIA	TIA	NNP
cord-006860-a3b8hyyr	916	15	than	than	IN
cord-006860-a3b8hyyr	916	16	analysing	analyse	VBG
cord-006860-a3b8hyyr	916	17	the	the	DT
cord-006860-a3b8hyyr	916	18	reversible	reversible	JJ
cord-006860-a3b8hyyr	916	19	shape	shape	NN
cord-006860-a3b8hyyr	916	20	change	change	NN
cord-006860-a3b8hyyr	916	21	.	.	.
cord-006860-a3b8hyyr	917	1	Further	further	JJ
cord-006860-a3b8hyyr	917	2	studies	study	NNS
cord-006860-a3b8hyyr	917	3	have	have	VBP
cord-006860-a3b8hyyr	917	4	to	to	TO
cord-006860-a3b8hyyr	917	5	clarify	clarify	VB
cord-006860-a3b8hyyr	917	6	if	if	IN
cord-006860-a3b8hyyr	917	7	monitoring	monitoring	NN
cord-006860-a3b8hyyr	917	8	of	of	IN
cord-006860-a3b8hyyr	917	9	platelet	platelet	NN
cord-006860-a3b8hyyr	917	10	activation	activation	NN
cord-006860-a3b8hyyr	917	11	by	by	IN
cord-006860-a3b8hyyr	917	12	flowcytometry	flowcytometry	NNP
cord-006860-a3b8hyyr	917	13	is	be	VBZ
cord-006860-a3b8hyyr	917	14	helpful	helpful	JJ
cord-006860-a3b8hyyr	917	15	as	as	IN
cord-006860-a3b8hyyr	917	16	a	a	DT
cord-006860-a3b8hyyr	917	17	prognostic	prognostic	JJ
cord-006860-a3b8hyyr	917	18	tool	tool	NN
cord-006860-a3b8hyyr	917	19	and	and	CC
cord-006860-a3b8hyyr	917	20	to	to	TO
cord-006860-a3b8hyyr	917	21	evaluate	evaluate	VB
cord-006860-a3b8hyyr	917	22	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	917	23	strategies	strategy	NNS
cord-006860-a3b8hyyr	917	24	after	after	IN
cord-006860-a3b8hyyr	917	25	stroke	stroke	NN
cord-006860-a3b8hyyr	917	26	.	.	.
cord-006860-a3b8hyyr	918	1	Vascular	vascular	JJ
cord-006860-a3b8hyyr	918	2	smooth	smooth	JJ
cord-006860-a3b8hyyr	918	3	muscle	muscle	NN
cord-006860-a3b8hyyr	918	4	cell	cell	NN
cord-006860-a3b8hyyr	918	5	(	(	-LRB-
cord-006860-a3b8hyyr	918	6	SMC	SMC	NNP
cord-006860-a3b8hyyr	918	7	)	)	-RRB-
cord-006860-a3b8hyyr	918	8	proliferation	proliferation	NN
cord-006860-a3b8hyyr	918	9	and	and	CC
cord-006860-a3b8hyyr	918	10	migration	migration	NN
cord-006860-a3b8hyyr	918	11	into	into	IN
cord-006860-a3b8hyyr	918	12	neointima	neointima	NNP
cord-006860-a3b8hyyr	918	13	are	be	VBP
cord-006860-a3b8hyyr	918	14	the	the	DT
cord-006860-a3b8hyyr	918	15	hallmarks	hallmark	NNS
cord-006860-a3b8hyyr	918	16	of	of	IN
cord-006860-a3b8hyyr	918	17	atherogenesis	atherogenesis	NN
cord-006860-a3b8hyyr	918	18	.	.	.
cord-006860-a3b8hyyr	919	1	The	the	DT
cord-006860-a3b8hyyr	919	2	complexity	complexity	NN
cord-006860-a3b8hyyr	919	3	of	of	IN
cord-006860-a3b8hyyr	919	4	these	these	DT
cord-006860-a3b8hyyr	919	5	processes	process	NNS
cord-006860-a3b8hyyr	919	6	and	and	CC
cord-006860-a3b8hyyr	919	7	their	-PRON-	PRP$
cord-006860-a3b8hyyr	919	8	concerted	concerted	JJ
cord-006860-a3b8hyyr	919	9	action	action	NN
cord-006860-a3b8hyyr	919	10	and	and	CC
cord-006860-a3b8hyyr	919	11	interaction	interaction	NN
cord-006860-a3b8hyyr	919	12	of	of	IN
cord-006860-a3b8hyyr	919	13	molecules	molecule	NNS
cord-006860-a3b8hyyr	919	14	are	be	VBP
cord-006860-a3b8hyyr	919	15	yet	yet	RB
cord-006860-a3b8hyyr	919	16	to	to	TO
cord-006860-a3b8hyyr	919	17	be	be	VB
cord-006860-a3b8hyyr	919	18	fully	fully	RB
cord-006860-a3b8hyyr	919	19	elucidated	elucidate	VBN
cord-006860-a3b8hyyr	919	20	,	,	,
cord-006860-a3b8hyyr	919	21	One	one	CD
cord-006860-a3b8hyyr	919	22	crucial	crucial	JJ
cord-006860-a3b8hyyr	919	23	molecule	molecule	NN
cord-006860-a3b8hyyr	919	24	seems	seem	VBZ
cord-006860-a3b8hyyr	919	25	to	to	TO
cord-006860-a3b8hyyr	919	26	be	be	VB
cord-006860-a3b8hyyr	919	27	the	the	DT
cord-006860-a3b8hyyr	919	28	urokinase	urokinase	NN
cord-006860-a3b8hyyr	919	29	-	-	HYPH
cord-006860-a3b8hyyr	919	30	type	type	NN
cord-006860-a3b8hyyr	919	31	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	919	32	activator	activator	NN
cord-006860-a3b8hyyr	919	33	receptor	receptor	NN
cord-006860-a3b8hyyr	919	34	(	(	-LRB-
cord-006860-a3b8hyyr	919	35	uPAR	uPAR	NNP
cord-006860-a3b8hyyr	919	36	)	)	-RRB-
cord-006860-a3b8hyyr	919	37	recently	recently	RB
cord-006860-a3b8hyyr	919	38	also	also	RB
cord-006860-a3b8hyyr	919	39	assigned	assign	VBN
cord-006860-a3b8hyyr	919	40	as	as	IN
cord-006860-a3b8hyyr	919	41	CD87	CD87	NNP
cord-006860-a3b8hyyr	919	42	antigen	antigen	NN
cord-006860-a3b8hyyr	919	43	,	,	,
cord-006860-a3b8hyyr	919	44	uPAR	uPAR	NNP
cord-006860-a3b8hyyr	919	45	serves	serve	VBZ
cord-006860-a3b8hyyr	919	46	a	a	DT
cord-006860-a3b8hyyr	919	47	dual	dual	JJ
cord-006860-a3b8hyyr	919	48	function	function	NN
cord-006860-a3b8hyyr	919	49	:	:	:
cord-006860-a3b8hyyr	919	50	(	(	-LRB-
cord-006860-a3b8hyyr	919	51	1	1	LS
cord-006860-a3b8hyyr	919	52	)	)	-RRB-
cord-006860-a3b8hyyr	919	53	it	-PRON-	PRP
cord-006860-a3b8hyyr	919	54	directs	direct	VBZ
cord-006860-a3b8hyyr	919	55	uPA	upa	NN
cord-006860-a3b8hyyr	919	56	proteolytic	proteolytic	JJ
cord-006860-a3b8hyyr	919	57	activity	activity	NN
cord-006860-a3b8hyyr	919	58	to	to	IN
cord-006860-a3b8hyyr	919	59	a	a	DT
cord-006860-a3b8hyyr	919	60	special	special	JJ
cord-006860-a3b8hyyr	919	61	location	location	NN
cord-006860-a3b8hyyr	919	62	on	on	IN
cord-006860-a3b8hyyr	919	63	the	the	DT
cord-006860-a3b8hyyr	919	64	cell	cell	NN
cord-006860-a3b8hyyr	919	65	surface	surface	NN
cord-006860-a3b8hyyr	919	66	and	and	CC
cord-006860-a3b8hyyr	919	67	(	(	-LRB-
cord-006860-a3b8hyyr	919	68	2	2	LS
cord-006860-a3b8hyyr	919	69	)	)	-RRB-
cord-006860-a3b8hyyr	919	70	induces	induce	VBZ
cord-006860-a3b8hyyr	919	71	cellular	cellular	JJ
cord-006860-a3b8hyyr	919	72	signals	signal	NNS
cord-006860-a3b8hyyr	919	73	leading	lead	VBG
cord-006860-a3b8hyyr	919	74	to	to	IN
cord-006860-a3b8hyyr	919	75	various	various	JJ
cord-006860-a3b8hyyr	919	76	phenotypic	phenotypic	JJ
cord-006860-a3b8hyyr	919	77	changes	change	NNS
cord-006860-a3b8hyyr	919	78	.	.	.
cord-006860-a3b8hyyr	920	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	920	2	have	have	VBP
cord-006860-a3b8hyyr	920	3	investigated	investigate	VBN
cord-006860-a3b8hyyr	920	4	the	the	DT
cord-006860-a3b8hyyr	920	5	signal	signal	NN
cord-006860-a3b8hyyr	920	6	-	-	HYPH
cord-006860-a3b8hyyr	920	7	transducing	transduce	VBG
cord-006860-a3b8hyyr	920	8	capacity	capacity	NN
cord-006860-a3b8hyyr	920	9	of	of	IN
cord-006860-a3b8hyyr	920	10	uPAR	upar	NN
cord-006860-a3b8hyyr	920	11	in	in	IN
cord-006860-a3b8hyyr	920	12	human	human	JJ
cord-006860-a3b8hyyr	920	13	SMCs	smc	NNS
cord-006860-a3b8hyyr	920	14	and	and	CC
cord-006860-a3b8hyyr	920	15	provide	provide	VB
cord-006860-a3b8hyyr	920	16	here	here	RB
cord-006860-a3b8hyyr	920	17	a	a	DT
cord-006860-a3b8hyyr	920	18	molecular	molecular	JJ
cord-006860-a3b8hyyr	920	19	explanation	explanation	NN
cord-006860-a3b8hyyr	920	20	for	for	IN
cord-006860-a3b8hyyr	920	21	uPARrelated	uparrelated	JJ
cord-006860-a3b8hyyr	920	22	cellular	cellular	JJ
cord-006860-a3b8hyyr	920	23	events	event	NNS
cord-006860-a3b8hyyr	920	24	.	.	.
cord-006860-a3b8hyyr	921	1	Activation	activation	NN
cord-006860-a3b8hyyr	921	2	of	of	IN
cord-006860-a3b8hyyr	921	3	these	these	DT
cord-006860-a3b8hyyr	921	4	cells	cell	NNS
cord-006860-a3b8hyyr	921	5	with	with	IN
cord-006860-a3b8hyyr	921	6	uPA	uPA	NNP
cord-006860-a3b8hyyr	921	7	(	(	-LRB-
cord-006860-a3b8hyyr	921	8	even	even	RB
cord-006860-a3b8hyyr	921	9	with	with	IN
cord-006860-a3b8hyyr	921	10	inactivated	inactivate	VBN
cord-006860-a3b8hyyr	921	11	catalytic	catalytic	JJ
cord-006860-a3b8hyyr	921	12	center	center	NN
cord-006860-a3b8hyyr	921	13	)	)	-RRB-
cord-006860-a3b8hyyr	921	14	results	result	NNS
cord-006860-a3b8hyyr	921	15	in	in	IN
cord-006860-a3b8hyyr	921	16	the	the	DT
cord-006860-a3b8hyyr	921	17	induction	induction	NN
cord-006860-a3b8hyyr	921	18	of	of	IN
cord-006860-a3b8hyyr	921	19	tyrosine	tyrosine	NN
cord-006860-a3b8hyyr	921	20	phosphorylation	phosphorylation	NN
cord-006860-a3b8hyyr	921	21	,	,	,
cord-006860-a3b8hyyr	921	22	suggesting	suggest	VBG
cord-006860-a3b8hyyr	921	23	modulation	modulation	NN
cord-006860-a3b8hyyr	921	24	of	of	IN
cord-006860-a3b8hyyr	921	25	uPAR	upar	JJ
cord-006860-a3b8hyyr	921	26	-	-	HYPH
cord-006860-a3b8hyyr	921	27	associated	associate	VBN
cord-006860-a3b8hyyr	921	28	protein	protein	NN
cord-006860-a3b8hyyr	921	29	tyrosine	tyrosine	NN
cord-006860-a3b8hyyr	921	30	kinases	kinase	NNS
cord-006860-a3b8hyyr	921	31	(	(	-LRB-
cord-006860-a3b8hyyr	921	32	PTKs	PTKs	NNP
cord-006860-a3b8hyyr	921	33	)	)	-RRB-
cord-006860-a3b8hyyr	921	34	upon	upon	IN
cord-006860-a3b8hyyr	921	35	ligand	ligand	NN
cord-006860-a3b8hyyr	921	36	binding	binding	NN
cord-006860-a3b8hyyr	921	37	.	.	.
cord-006860-a3b8hyyr	922	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	922	2	obtained	obtain	VBD
cord-006860-a3b8hyyr	922	3	patterns	pattern	NNS
cord-006860-a3b8hyyr	922	4	of	of	IN
cord-006860-a3b8hyyr	922	5	tyrosine	tyrosine	NN
cord-006860-a3b8hyyr	922	6	-	-	HYPH
cord-006860-a3b8hyyr	922	7	phosphorylated	phosphorylate	VBN
cord-006860-a3b8hyyr	922	8	proteins	protein	NNS
cord-006860-a3b8hyyr	922	9	with	with	IN
cord-006860-a3b8hyyr	922	10	molecular	molecular	JJ
cord-006860-a3b8hyyr	922	11	masses	masse	NNS
cord-006860-a3b8hyyr	922	12	of	of	IN
cord-006860-a3b8hyyr	922	13	~	~	CD
cord-006860-a3b8hyyr	923	1	55	55	CD
cord-006860-a3b8hyyr	923	2	-	-	SYM
cord-006860-a3b8hyyr	923	3	65	65	CD
cord-006860-a3b8hyyr	923	4	and	and	CC
cord-006860-a3b8hyyr	923	5	35	35	CD
cord-006860-a3b8hyyr	923	6	-	-	SYM
cord-006860-a3b8hyyr	923	7	40	40	CD
cord-006860-a3b8hyyr	923	8	kD.	kd.	NN
cord-006860-a3b8hyyr	923	9	Using	use	VBG
cord-006860-a3b8hyyr	923	10	antibodies	antibody	NNS
cord-006860-a3b8hyyr	923	11	against	against	IN
cord-006860-a3b8hyyr	923	12	different	different	JJ
cord-006860-a3b8hyyr	923	13	types	type	NNS
cord-006860-a3b8hyyr	923	14	of	of	IN
cord-006860-a3b8hyyr	923	15	PTKs	PTKs	NNP
cord-006860-a3b8hyyr	923	16	as	as	RB
cord-006860-a3b8hyyr	923	17	well	well	RB
cord-006860-a3b8hyyr	923	18	as	as	IN
cord-006860-a3b8hyyr	923	19	immunoprecipitation	immunoprecipitation	NN
cord-006860-a3b8hyyr	923	20	-	-	:
cord-006860-a3b8hyyr	923	21	and	and	CC
cord-006860-a3b8hyyr	923	22	immunoblotting	immunoblotting	NN
cord-006860-a3b8hyyr	923	23	techniques	technique	NNS
cord-006860-a3b8hyyr	923	24	the	the	DT
cord-006860-a3b8hyyr	923	25	PTKs	PTKs	NNPS
cord-006860-a3b8hyyr	923	26	involved	involve	VBN
cord-006860-a3b8hyyr	923	27	in	in	IN
cord-006860-a3b8hyyr	923	28	the	the	DT
cord-006860-a3b8hyyr	923	29	uPAR	upar	RB
cord-006860-a3b8hyyr	923	30	-	-	HYPH
cord-006860-a3b8hyyr	923	31	signalling	signal	VBG
cord-006860-a3b8hyyr	923	32	complex	complex	NN
cord-006860-a3b8hyyr	923	33	were	be	VBD
cord-006860-a3b8hyyr	923	34	identified	identify	VBN
cord-006860-a3b8hyyr	923	35	to	to	TO
cord-006860-a3b8hyyr	923	36	be	be	VB
cord-006860-a3b8hyyr	923	37	members	member	NNS
cord-006860-a3b8hyyr	923	38	of	of	IN
cord-006860-a3b8hyyr	923	39	the	the	DT
cord-006860-a3b8hyyr	923	40	Src	Src	NNP
cord-006860-a3b8hyyr	923	41	-	-	HYPH
cord-006860-a3b8hyyr	923	42	PTK	PTK	NNP
cord-006860-a3b8hyyr	923	43	family	family	NN
cord-006860-a3b8hyyr	923	44	.	.	.
cord-006860-a3b8hyyr	924	1	The	the	DT
cord-006860-a3b8hyyr	924	2	cotocalization	cotocalization	NN
cord-006860-a3b8hyyr	924	3	of	of	IN
cord-006860-a3b8hyyr	924	4	uPAR	uPAR	NNP
cord-006860-a3b8hyyr	924	5	and	and	CC
cord-006860-a3b8hyyr	924	6	PTKs	ptk	NNS
cord-006860-a3b8hyyr	924	7	at	at	IN
cord-006860-a3b8hyyr	924	8	the	the	DT
cord-006860-a3b8hyyr	924	9	cell	cell	NN
cord-006860-a3b8hyyr	924	10	surface	surface	NN
cord-006860-a3b8hyyr	924	11	of	of	IN
cord-006860-a3b8hyyr	924	12	SMCs	smc	NNS
cord-006860-a3b8hyyr	924	13	was	be	VBD
cord-006860-a3b8hyyr	924	14	further	further	RB
cord-006860-a3b8hyyr	924	15	confirmed	confirm	VBN
cord-006860-a3b8hyyr	924	16	by	by	IN
cord-006860-a3b8hyyr	924	17	confocal	confocal	JJ
cord-006860-a3b8hyyr	924	18	microscopy	microscopy	NN
cord-006860-a3b8hyyr	924	19	studies	study	NNS
cord-006860-a3b8hyyr	924	20	.	.	.
cord-006860-a3b8hyyr	925	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	925	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	925	3	that	that	IN
cord-006860-a3b8hyyr	925	4	the	the	DT
cord-006860-a3b8hyyr	925	5	uPAR	upar	JJ
cord-006860-a3b8hyyr	925	6	-	-	HYPH
cord-006860-a3b8hyyr	925	7	PTK	ptk	NN
cord-006860-a3b8hyyr	925	8	complex	complex	NN
cord-006860-a3b8hyyr	925	9	is	be	VBZ
cord-006860-a3b8hyyr	925	10	most	most	RBS
cord-006860-a3b8hyyr	925	11	likely	likely	RB
cord-006860-a3b8hyyr	925	12	involved	involve	VBN
cord-006860-a3b8hyyr	925	13	in	in	IN
cord-006860-a3b8hyyr	925	14	this	this	DT
cord-006860-a3b8hyyr	925	15	signal	signal	NN
cord-006860-a3b8hyyr	925	16	transduction	transduction	NN
cord-006860-a3b8hyyr	925	17	pathway	pathway	NN
cord-006860-a3b8hyyr	925	18	that	that	WDT
cord-006860-a3b8hyyr	925	19	provides	provide	VBZ
cord-006860-a3b8hyyr	925	20	the	the	DT
cord-006860-a3b8hyyr	925	21	coordinated	coordinated	JJ
cord-006860-a3b8hyyr	925	22	action	action	NN
cord-006860-a3b8hyyr	925	23	of	of	IN
cord-006860-a3b8hyyr	925	24	extracellular	extracellular	JJ
cord-006860-a3b8hyyr	925	25	proteolysis	proteolysis	NN
cord-006860-a3b8hyyr	925	26	,	,	,
cord-006860-a3b8hyyr	925	27	adhesion	adhesion	NN
cord-006860-a3b8hyyr	925	28	,	,	,
cord-006860-a3b8hyyr	925	29	and	and	CC
cord-006860-a3b8hyyr	925	30	cell	cell	NN
cord-006860-a3b8hyyr	925	31	activation	activation	NN
cord-006860-a3b8hyyr	925	32	,	,	,
cord-006860-a3b8hyyr	925	33	which	which	WDT
cord-006860-a3b8hyyr	925	34	is	be	VBZ
cord-006860-a3b8hyyr	925	35	required	require	VBN
cord-006860-a3b8hyyr	925	36	for	for	IN
cord-006860-a3b8hyyr	925	37	cell	cell	NN
cord-006860-a3b8hyyr	925	38	migration	migration	NN
cord-006860-a3b8hyyr	925	39	.	.	.
cord-006860-a3b8hyyr	926	1	This	this	DT
cord-006860-a3b8hyyr	926	2	mechanism	mechanism	NN
cord-006860-a3b8hyyr	926	3	may	may	MD
cord-006860-a3b8hyyr	926	4	be	be	VB
cord-006860-a3b8hyyr	926	5	crucial	crucial	JJ
cord-006860-a3b8hyyr	926	6	for	for	IN
cord-006860-a3b8hyyr	926	7	the	the	DT
cord-006860-a3b8hyyr	926	8	progression	progression	NN
cord-006860-a3b8hyyr	926	9	of	of	IN
cord-006860-a3b8hyyr	926	10	atherosclerotic	atherosclerotic	JJ
cord-006860-a3b8hyyr	926	11	plaques	plaque	NNS
cord-006860-a3b8hyyr	926	12	.	.	.
cord-006860-a3b8hyyr	927	1	Activation	activation	NN
cord-006860-a3b8hyyr	927	2	markers	marker	NNS
cord-006860-a3b8hyyr	927	3	of	of	IN
cord-006860-a3b8hyyr	927	4	haemostasis	haemostasis	NN
cord-006860-a3b8hyyr	927	5	have	have	VBP
cord-006860-a3b8hyyr	927	6	been	be	VBN
cord-006860-a3b8hyyr	927	7	found	find	VBN
cord-006860-a3b8hyyr	927	8	elevated	elevate	VBN
cord-006860-a3b8hyyr	927	9	in	in	IN
cord-006860-a3b8hyyr	927	10	relation	relation	NN
cord-006860-a3b8hyyr	927	11	to	to	IN
cord-006860-a3b8hyyr	927	12	diabetic	diabetic	JJ
cord-006860-a3b8hyyr	927	13	vascular	vascular	JJ
cord-006860-a3b8hyyr	927	14	lesions	lesion	NNS
cord-006860-a3b8hyyr	927	15	.	.	.
cord-006860-a3b8hyyr	928	1	Simultaneous	simultaneous	JJ
cord-006860-a3b8hyyr	928	2	pancreas	pancrea	NNS
cord-006860-a3b8hyyr	928	3	-	-	HYPH
cord-006860-a3b8hyyr	928	4	and	and	CC
cord-006860-a3b8hyyr	928	5	kidney	kidney	NN
cord-006860-a3b8hyyr	928	6	transplantation	transplantation	NN
cord-006860-a3b8hyyr	928	7	(	(	-LRB-
cord-006860-a3b8hyyr	928	8	PKT	PKT	NNP
cord-006860-a3b8hyyr	928	9	)	)	-RRB-
cord-006860-a3b8hyyr	928	10	in	in	IN
cord-006860-a3b8hyyr	928	11	Type	type	NN
cord-006860-a3b8hyyr	928	12	I	-PRON-	PRP
cord-006860-a3b8hyyr	928	13	Diabetes	diabetes	NN
cord-006860-a3b8hyyr	928	14	has	have	VBZ
cord-006860-a3b8hyyr	928	15	been	be	VBN
cord-006860-a3b8hyyr	928	16	shown	show	VBN
cord-006860-a3b8hyyr	928	17	to	to	TO
cord-006860-a3b8hyyr	928	18	improve	improve	VB
cord-006860-a3b8hyyr	928	19	diabetic	diabetic	JJ
cord-006860-a3b8hyyr	928	20	complications	complication	NNS
cord-006860-a3b8hyyr	928	21	and	and	CC
cord-006860-a3b8hyyr	928	22	long	long	JJ
cord-006860-a3b8hyyr	928	23	term	term	NN
cord-006860-a3b8hyyr	928	24	survival	survival	NN
cord-006860-a3b8hyyr	928	25	.	.	.
cord-006860-a3b8hyyr	929	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	929	2	measured	measure	VBD
cord-006860-a3b8hyyr	929	3	haemostatic	haemostatic	JJ
cord-006860-a3b8hyyr	929	4	vascular	vascular	JJ
cord-006860-a3b8hyyr	929	5	risk	risk	NN
cord-006860-a3b8hyyr	929	6	factors	factor	NNS
cord-006860-a3b8hyyr	929	7	and	and	CC
cord-006860-a3b8hyyr	929	8	activation	activation	NN
cord-006860-a3b8hyyr	929	9	markers	marker	NNS
cord-006860-a3b8hyyr	929	10	in	in	IN
cord-006860-a3b8hyyr	929	11	plasma	plasma	NN
cord-006860-a3b8hyyr	929	12	of	of	IN
cord-006860-a3b8hyyr	929	13	18	18	CD
cord-006860-a3b8hyyr	929	14	patients	patient	NNS
cord-006860-a3b8hyyr	929	15	after	after	IN
cord-006860-a3b8hyyr	929	16	successful	successful	JJ
cord-006860-a3b8hyyr	929	17	PKI	PKI	NNP
cord-006860-a3b8hyyr	929	18	'	'	''
cord-006860-a3b8hyyr	929	19	,	,	,
cord-006860-a3b8hyyr	929	20	17	17	CD
cord-006860-a3b8hyyr	929	21	patients	patient	NNS
cord-006860-a3b8hyyr	929	22	after	after	IN
cord-006860-a3b8hyyr	929	23	PKT	pkt	NN
cord-006860-a3b8hyyr	929	24	and	and	CC
cord-006860-a3b8hyyr	929	25	rejection	rejection	NN
cord-006860-a3b8hyyr	929	26	of	of	IN
cord-006860-a3b8hyyr	929	27	the	the	DT
cord-006860-a3b8hyyr	929	28	pancreas	pancreas	NN
cord-006860-a3b8hyyr	929	29	graft	graft	NN
cord-006860-a3b8hyyr	929	30	and	and	CC
cord-006860-a3b8hyyr	929	31	5	5	CD
cord-006860-a3b8hyyr	929	32	patients	patient	NNS
cord-006860-a3b8hyyr	929	33	after	after	IN
cord-006860-a3b8hyyr	929	34	PKT	pkt	NN
cord-006860-a3b8hyyr	929	35	and	and	CC
cord-006860-a3b8hyyr	929	36	rejection	rejection	NN
cord-006860-a3b8hyyr	929	37	of	of	IN
cord-006860-a3b8hyyr	929	38	the	the	DT
cord-006860-a3b8hyyr	929	39	renal	renal	JJ
cord-006860-a3b8hyyr	929	40	graft	graft	NN
cord-006860-a3b8hyyr	929	41	.	.	.
cord-006860-a3b8hyyr	930	1	Blood	blood	NN
cord-006860-a3b8hyyr	930	2	samples	sample	NNS
cord-006860-a3b8hyyr	930	3	were	be	VBD
cord-006860-a3b8hyyr	930	4	taken	take	VBN
cord-006860-a3b8hyyr	930	5	during	during	IN
cord-006860-a3b8hyyr	930	6	routine	routine	JJ
cord-006860-a3b8hyyr	930	7	ambulatory	ambulatory	JJ
cord-006860-a3b8hyyr	930	8	visits	visit	NNS
cord-006860-a3b8hyyr	930	9	,	,	,
cord-006860-a3b8hyyr	930	10	patients	patient	NNS
cord-006860-a3b8hyyr	930	11	were	be	VBD
cord-006860-a3b8hyyr	930	12	free	free	JJ
cord-006860-a3b8hyyr	930	13	of	of	IN
cord-006860-a3b8hyyr	930	14	any	any	DT
cord-006860-a3b8hyyr	930	15	ongoing	ongoing	JJ
cord-006860-a3b8hyyr	930	16	acute	acute	JJ
cord-006860-a3b8hyyr	930	17	disorder	disorder	NN
cord-006860-a3b8hyyr	930	18	or	or	CC
cord-006860-a3b8hyyr	930	19	transplant	transplant	NN
cord-006860-a3b8hyyr	930	20	rejection	rejection	NN
cord-006860-a3b8hyyr	930	21	and	and	CC
cord-006860-a3b8hyyr	930	22	under	under	IN
cord-006860-a3b8hyyr	930	23	continuous	continuous	JJ
cord-006860-a3b8hyyr	930	24	immunosuppressive	immunosuppressive	JJ
cord-006860-a3b8hyyr	930	25	medication	medication	NN
cord-006860-a3b8hyyr	930	26	.	.	.
cord-006860-a3b8hyyr	931	1	Despite	despite	IN
cord-006860-a3b8hyyr	931	2	individually	individually	RB
cord-006860-a3b8hyyr	931	3	adjusted	adjust	VBN
cord-006860-a3b8hyyr	931	4	insulin	insulin	NN
cord-006860-a3b8hyyr	931	5	therapy	therapy	NN
cord-006860-a3b8hyyr	931	6	HbA1	hba1	POS
cord-006860-a3b8hyyr	931	7	plasma	plasma	NN
cord-006860-a3b8hyyr	931	8	levels	level	NNS
cord-006860-a3b8hyyr	931	9	increased	increase	VBD
cord-006860-a3b8hyyr	931	10	after	after	IN
cord-006860-a3b8hyyr	931	11	pancreas	pancreas	NN
cord-006860-a3b8hyyr	931	12	rejection	rejection	NN
cord-006860-a3b8hyyr	931	13	(	(	-LRB-
cord-006860-a3b8hyyr	931	14	5,37	5,37	CD
cord-006860-a3b8hyyr	931	15	vs	vs	IN
cord-006860-a3b8hyyr	931	16	7,I2	7,i2	CD
cord-006860-a3b8hyyr	931	17	,	,	,
cord-006860-a3b8hyyr	931	18	p<0.001	p<0.001	CD
cord-006860-a3b8hyyr	931	19	)	)	-RRB-
cord-006860-a3b8hyyr	931	20	.	.	.
cord-006860-a3b8hyyr	932	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	932	2	counts	count	NNS
cord-006860-a3b8hyyr	932	3	and	and	CC
cord-006860-a3b8hyyr	932	4	plasma	plasma	NN
cord-006860-a3b8hyyr	932	5	levels	level	NNS
cord-006860-a3b8hyyr	932	6	of	of	IN
cord-006860-a3b8hyyr	932	7	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	932	8	,	,	,
cord-006860-a3b8hyyr	932	9	F1	f1	NN
cord-006860-a3b8hyyr	932	10	+	+	CC
cord-006860-a3b8hyyr	933	1	2	2	CD
cord-006860-a3b8hyyr	933	2	fragment	fragment	NN
cord-006860-a3b8hyyr	933	3	,	,	,
cord-006860-a3b8hyyr	933	4	TAT-	TAT-	NNP
cord-006860-a3b8hyyr	933	5	,	,	,
cord-006860-a3b8hyyr	933	6	APP	app	NN
cord-006860-a3b8hyyr	933	7	-	-	HYPH
cord-006860-a3b8hyyr	933	8	complex	complex	JJ
cord-006860-a3b8hyyr	933	9	and	and	CC
cord-006860-a3b8hyyr	933	10	-	-	HYPH
cord-006860-a3b8hyyr	933	11	Fibrin	fibrin	NN
cord-006860-a3b8hyyr	933	12	Monomer	Monomer	NNP
cord-006860-a3b8hyyr	933	13	were	be	VBD
cord-006860-a3b8hyyr	933	14	found	find	VBN
cord-006860-a3b8hyyr	933	15	significantly	significantly	RB
cord-006860-a3b8hyyr	933	16	elevated	elevate	VBN
cord-006860-a3b8hyyr	933	17	as	as	IN
cord-006860-a3b8hyyr	933	18	compared	compare	VBN
cord-006860-a3b8hyyr	933	19	to	to	IN
cord-006860-a3b8hyyr	933	20	diabetic	diabetic	JJ
cord-006860-a3b8hyyr	933	21	controls	control	NNS
cord-006860-a3b8hyyr	933	22	but	but	CC
cord-006860-a3b8hyyr	933	23	not	not	RB
cord-006860-a3b8hyyr	933	24	significantly	significantly	RB
cord-006860-a3b8hyyr	933	25	different	different	JJ
cord-006860-a3b8hyyr	933	26	with	with	IN
cord-006860-a3b8hyyr	933	27	respect	respect	NN
cord-006860-a3b8hyyr	933	28	to	to	TO
cord-006860-a3b8hyyr	933	29	complete	complete	JJ
cord-006860-a3b8hyyr	933	30	or	or	CC
cord-006860-a3b8hyyr	933	31	partial	partial	JJ
cord-006860-a3b8hyyr	933	32	successful	successful	JJ
cord-006860-a3b8hyyr	933	33	PKT	pkt	NN
cord-006860-a3b8hyyr	933	34	.	.	.
cord-006860-a3b8hyyr	934	1	One	one	CD
cord-006860-a3b8hyyr	934	2	major	major	JJ
cord-006860-a3b8hyyr	934	3	reason	reason	NN
cord-006860-a3b8hyyr	934	4	of	of	IN
cord-006860-a3b8hyyr	934	5	the	the	DT
cord-006860-a3b8hyyr	934	6	increased	increase	VBN
cord-006860-a3b8hyyr	934	7	activation	activation	NN
cord-006860-a3b8hyyr	934	8	state	state	NN
cord-006860-a3b8hyyr	934	9	of	of	IN
cord-006860-a3b8hyyr	934	10	haemostasis	haemostasis	NN
cord-006860-a3b8hyyr	934	11	may	may	MD
cord-006860-a3b8hyyr	934	12	be	be	VB
cord-006860-a3b8hyyr	934	13	Cyclosporin	Cyclosporin	NNP
cord-006860-a3b8hyyr	934	14	treatment	treatment	NN
cord-006860-a3b8hyyr	934	15	given	give	VBN
cord-006860-a3b8hyyr	934	16	to	to	IN
cord-006860-a3b8hyyr	934	17	all	all	DT
cord-006860-a3b8hyyr	934	18	patients	patient	NNS
cord-006860-a3b8hyyr	934	19	,	,	,
cord-006860-a3b8hyyr	934	20	t	t	NNP
cord-006860-a3b8hyyr	934	21	-	-	HYPH
cord-006860-a3b8hyyr	934	22	PA	PA	NNP
cord-006860-a3b8hyyr	934	23	and	and	CC
cord-006860-a3b8hyyr	934	24	PAl	PAl	NNS
cord-006860-a3b8hyyr	934	25	I	-PRON-	PRP
cord-006860-a3b8hyyr	934	26	plasma	plasma	NN
cord-006860-a3b8hyyr	934	27	levels	level	NNS
cord-006860-a3b8hyyr	934	28	were	be	VBD
cord-006860-a3b8hyyr	934	29	within	within	IN
cord-006860-a3b8hyyr	934	30	the	the	DT
cord-006860-a3b8hyyr	934	31	normal	normal	JJ
cord-006860-a3b8hyyr	934	32	range	range	NN
cord-006860-a3b8hyyr	934	33	and	and	CC
cord-006860-a3b8hyyr	934	34	significantly	significantly	RB
cord-006860-a3b8hyyr	934	35	correlated	correlate	VBD
cord-006860-a3b8hyyr	934	36	to	to	IN
cord-006860-a3b8hyyr	934	37	plasma	plasma	NN
cord-006860-a3b8hyyr	934	38	triglyceddes	triglyceddes	NNP
cord-006860-a3b8hyyr	934	39	(	(	-LRB-
cord-006860-a3b8hyyr	934	40	r.0.049	r.0.049	NNP
cord-006860-a3b8hyyr	934	41	;	;	:
cord-006860-a3b8hyyr	934	42	p<0.005	p<0.005	CD
cord-006860-a3b8hyyr	934	43	)	)	-RRB-
cord-006860-a3b8hyyr	934	44	.	.	.
cord-006860-a3b8hyyr	935	1	D	D	NNP
cord-006860-a3b8hyyr	935	2	-	-	HYPH
cord-006860-a3b8hyyr	935	3	Dimer	dimer	NN
cord-006860-a3b8hyyr	935	4	plasma	plasma	NN
cord-006860-a3b8hyyr	935	5	levels	level	NNS
cord-006860-a3b8hyyr	935	6	were	be	VBD
cord-006860-a3b8hyyr	935	7	significantly	significantly	RB
cord-006860-a3b8hyyr	935	8	lowered	lower	VBN
cord-006860-a3b8hyyr	935	9	after	after	IN
cord-006860-a3b8hyyr	935	10	pancreas	pancreas	NN
cord-006860-a3b8hyyr	935	11	rejection	rejection	NN
cord-006860-a3b8hyyr	935	12	(	(	-LRB-
cord-006860-a3b8hyyr	935	13	772(375	772(375	CD
cord-006860-a3b8hyyr	935	14	)	)	-RRB-
cord-006860-a3b8hyyr	935	15	vs	vs	IN
cord-006860-a3b8hyyr	935	16	324(232	324(232	CD
cord-006860-a3b8hyyr	935	17	)	)	-RRB-
cord-006860-a3b8hyyr	935	18	nglml	nglml	NNP
cord-006860-a3b8hyyr	935	19	;	;	:
cord-006860-a3b8hyyr	935	20	Mean(SEM	Mean(SEM	NNP
cord-006860-a3b8hyyr	935	21	)	)	-RRB-
cord-006860-a3b8hyyr	935	22	p<0.005	p<0.005	CD
cord-006860-a3b8hyyr	935	23	)	)	-RRB-
cord-006860-a3b8hyyr	935	24	,	,	,
cord-006860-a3b8hyyr	935	25	which	which	WDT
cord-006860-a3b8hyyr	935	26	might	may	MD
cord-006860-a3b8hyyr	935	27	reflect	reflect	VB
cord-006860-a3b8hyyr	935	28	impaired	impaired	JJ
cord-006860-a3b8hyyr	935	29	fibrin	fibrin	NN
cord-006860-a3b8hyyr	935	30	degradation	degradation	NN
cord-006860-a3b8hyyr	935	31	related	relate	VBN
cord-006860-a3b8hyyr	935	32	to	to	IN
cord-006860-a3b8hyyr	935	33	increased	increase	VBN
cord-006860-a3b8hyyr	935	34	glycosylation	glycosylation	NN
cord-006860-a3b8hyyr	935	35	of	of	IN
cord-006860-a3b8hyyr	935	36	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	935	37	factors	factor	NNS
cord-006860-a3b8hyyr	935	38	.	.	.
cord-006860-a3b8hyyr	936	1	In	in	IN
cord-006860-a3b8hyyr	936	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	936	3	,	,	,
cord-006860-a3b8hyyr	936	4	despite	despite	IN
cord-006860-a3b8hyyr	936	5	the	the	DT
cord-006860-a3b8hyyr	936	6	marked	mark	VBN
cord-006860-a3b8hyyr	936	7	improvement	improvement	NN
cord-006860-a3b8hyyr	936	8	of	of	IN
cord-006860-a3b8hyyr	936	9	glucose	glucose	NN
cord-006860-a3b8hyyr	936	10	and	and	CC
cord-006860-a3b8hyyr	936	11	lipid	lipid	NN
cord-006860-a3b8hyyr	936	12	metabolism	metabolism	NN
cord-006860-a3b8hyyr	936	13	,	,	,
cord-006860-a3b8hyyr	936	14	plasma	plasma	NN
cord-006860-a3b8hyyr	936	15	markers	marker	NNS
cord-006860-a3b8hyyr	936	16	of	of	IN
cord-006860-a3b8hyyr	936	17	activation	activation	NN
cord-006860-a3b8hyyr	936	18	of	of	IN
cord-006860-a3b8hyyr	936	19	coagulation	coagulation	NN
cord-006860-a3b8hyyr	936	20	and	and	CC
cord-006860-a3b8hyyr	936	21	flbrinolysis	flbrinolysis	NN
cord-006860-a3b8hyyr	936	22	are	be	VBP
cord-006860-a3b8hyyr	936	23	not	not	RB
cord-006860-a3b8hyyr	936	24	decreased	decrease	VBN
cord-006860-a3b8hyyr	936	25	to	to	IN
cord-006860-a3b8hyyr	936	26	normal	normal	JJ
cord-006860-a3b8hyyr	936	27	after	after	IN
cord-006860-a3b8hyyr	936	28	simultaneous	simultaneous	JJ
cord-006860-a3b8hyyr	936	29	pancreas	pancrea	NNS
cord-006860-a3b8hyyr	936	30	and	and	CC
cord-006860-a3b8hyyr	936	31	kidney	kidney	NN
cord-006860-a3b8hyyr	936	32	transplantation	transplantation	NN
cord-006860-a3b8hyyr	936	33	.	.	.
cord-006860-a3b8hyyr	937	1	According	accord	VBG
cord-006860-a3b8hyyr	937	2	to	to	IN
cord-006860-a3b8hyyr	937	3	the	the	DT
cord-006860-a3b8hyyr	937	4	investigations	investigation	NNS
cord-006860-a3b8hyyr	937	5	of	of	IN
cord-006860-a3b8hyyr	937	6	Fowler	Fowler	NNP
cord-006860-a3b8hyyr	937	7	et	et	NNP
cord-006860-a3b8hyyr	937	8	al	al	NNP
cord-006860-a3b8hyyr	937	9	.	.	.
cord-006860-a3b8hyyr	938	1	and	and	CC
cord-006860-a3b8hyyr	938	2	Pepe	Pepe	NNP
cord-006860-a3b8hyyr	938	3	et	et	NNP
cord-006860-a3b8hyyr	938	4	al	al	NNP
cord-006860-a3b8hyyr	938	5	.	.	.
cord-006860-a3b8hyyr	939	1	the	the	DT
cord-006860-a3b8hyyr	939	2	probability	probability	NN
cord-006860-a3b8hyyr	939	3	of	of	IN
cord-006860-a3b8hyyr	939	4	an	an	DT
cord-006860-a3b8hyyr	939	5	ARDS	ARDS	NNP
cord-006860-a3b8hyyr	939	6	occurring	occur	VBG
cord-006860-a3b8hyyr	939	7	with	with	IN
cord-006860-a3b8hyyr	939	8	one	one	CD
cord-006860-a3b8hyyr	939	9	risk	risk	NN
cord-006860-a3b8hyyr	939	10	factor	factor	NN
cord-006860-a3b8hyyr	939	11	is	be	VBZ
cord-006860-a3b8hyyr	939	12	5	5	CD
cord-006860-a3b8hyyr	939	13	-	-	SYM
cord-006860-a3b8hyyr	939	14	8	8	CD
cord-006860-a3b8hyyr	939	15	%	%	NN
cord-006860-a3b8hyyr	939	16	,	,	,
cord-006860-a3b8hyyr	939	17	and	and	CC
cord-006860-a3b8hyyr	939	18	in	in	IN
cord-006860-a3b8hyyr	939	19	the	the	DT
cord-006860-a3b8hyyr	939	20	presence	presence	NN
cord-006860-a3b8hyyr	939	21	of	of	IN
cord-006860-a3b8hyyr	939	22	several	several	JJ
cord-006860-a3b8hyyr	939	23	risk	risk	NN
cord-006860-a3b8hyyr	939	24	factors	factor	NNS
cord-006860-a3b8hyyr	939	25	,	,	,
cord-006860-a3b8hyyr	939	26	25	25	CD
cord-006860-a3b8hyyr	939	27	%	%	NN
cord-006860-a3b8hyyr	939	28	.	.	.
cord-006860-a3b8hyyr	940	1	Goris	Goris	NNP
cord-006860-a3b8hyyr	940	2	et	et	FW
cord-006860-a3b8hyyr	940	3	al	al	NNP
cord-006860-a3b8hyyr	940	4	.	.	.
cord-006860-a3b8hyyr	941	1	and	and	CC
cord-006860-a3b8hyyr	941	2	Johnson	Johnson	NNP
cord-006860-a3b8hyyr	941	3	et	et	NNP
cord-006860-a3b8hyyr	941	4	al	al	NNP
cord-006860-a3b8hyyr	941	5	.	.	.
cord-006860-a3b8hyyr	942	1	determined	determine	VBD
cord-006860-a3b8hyyr	942	2	the	the	DT
cord-006860-a3b8hyyr	942	3	level	level	NN
cord-006860-a3b8hyyr	942	4	of	of	IN
cord-006860-a3b8hyyr	942	5	severity	severity	NN
cord-006860-a3b8hyyr	942	6	with	with	IN
cord-006860-a3b8hyyr	942	7	the	the	DT
cord-006860-a3b8hyyr	942	8	aid	aid	NN
cord-006860-a3b8hyyr	942	9	of	of	IN
cord-006860-a3b8hyyr	942	10	a	a	DT
cord-006860-a3b8hyyr	942	11	fixed	fix	VBN
cord-006860-a3b8hyyr	942	12	scale	scale	NN
cord-006860-a3b8hyyr	942	13	:	:	:
cord-006860-a3b8hyyr	942	14	the	the	DT
cord-006860-a3b8hyyr	942	15	injury	injury	NN
cord-006860-a3b8hyyr	942	16	severity	severity	NN
cord-006860-a3b8hyyr	942	17	score	score	NN
cord-006860-a3b8hyyr	942	18	.	.	.
cord-006860-a3b8hyyr	943	1	All	all	PDT
cord-006860-a3b8hyyr	943	2	these	these	DT
cord-006860-a3b8hyyr	943	3	investigations	investigation	NNS
cord-006860-a3b8hyyr	943	4	are	be	VBP
cord-006860-a3b8hyyr	943	5	however	however	RB
cord-006860-a3b8hyyr	943	6	not	not	RB
cord-006860-a3b8hyyr	943	7	to	to	TO
cord-006860-a3b8hyyr	943	8	be	be	VB
cord-006860-a3b8hyyr	943	9	interpreted	interpret	VBN
cord-006860-a3b8hyyr	943	10	as	as	IN
cord-006860-a3b8hyyr	943	11	typical	typical	JJ
cord-006860-a3b8hyyr	943	12	following	follow	VBG
cord-006860-a3b8hyyr	943	13	coronary	coronary	JJ
cord-006860-a3b8hyyr	943	14	surgery	surgery	NN
cord-006860-a3b8hyyr	943	15	.	.	.
cord-006860-a3b8hyyr	944	1	These	these	DT
cord-006860-a3b8hyyr	944	2	investigations	investigation	NNS
cord-006860-a3b8hyyr	944	3	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	944	4	that	that	IN
cord-006860-a3b8hyyr	944	5	the	the	DT
cord-006860-a3b8hyyr	944	6	kallikrein	kallikrein	NN
cord-006860-a3b8hyyr	944	7	and	and	CC
cord-006860-a3b8hyyr	944	8	factor	factor	NN
cord-006860-a3b8hyyr	944	9	XII	XII	NNP
cord-006860-a3b8hyyr	944	10	systems	system	NNS
cord-006860-a3b8hyyr	944	11	are	be	VBP
cord-006860-a3b8hyyr	944	12	of	of	IN
cord-006860-a3b8hyyr	944	13	great	great	JJ
cord-006860-a3b8hyyr	944	14	importance	importance	NN
cord-006860-a3b8hyyr	944	15	as	as	IN
cord-006860-a3b8hyyr	944	16	intraoperative	intraoperative	JJ
cord-006860-a3b8hyyr	944	17	risk	risk	NN
cord-006860-a3b8hyyr	944	18	factors	factor	NNS
cord-006860-a3b8hyyr	944	19	.	.	.
cord-006860-a3b8hyyr	945	1	Here	here	RB
cord-006860-a3b8hyyr	945	2	the	the	DT
cord-006860-a3b8hyyr	945	3	factor	factor	NN
cord-006860-a3b8hyyr	945	4	XII	XII	NNP
cord-006860-a3b8hyyr	945	5	system	system	NN
cord-006860-a3b8hyyr	945	6	plays	play	VBZ
cord-006860-a3b8hyyr	945	7	a	a	DT
cord-006860-a3b8hyyr	945	8	major	major	JJ
cord-006860-a3b8hyyr	945	9	role	role	NN
cord-006860-a3b8hyyr	945	10	with	with	IN
cord-006860-a3b8hyyr	945	11	direct	direct	JJ
cord-006860-a3b8hyyr	945	12	or	or	CC
cord-006860-a3b8hyyr	945	13	indirect	indirect	JJ
cord-006860-a3b8hyyr	945	14	activation	activation	NN
cord-006860-a3b8hyyr	945	15	of	of	IN
cord-006860-a3b8hyyr	945	16	the	the	DT
cord-006860-a3b8hyyr	945	17	kaUikrein	kaUikrein	NNP
cord-006860-a3b8hyyr	945	18	-	-	HYPH
cord-006860-a3b8hyyr	945	19	kinin	kinin	NNP
cord-006860-a3b8hyyr	945	20	system	system	NN
cord-006860-a3b8hyyr	945	21	with	with	IN
cord-006860-a3b8hyyr	945	22	the	the	DT
cord-006860-a3b8hyyr	945	23	splitting	splitting	JJ
cord-006860-a3b8hyyr	945	24	products	product	NNS
cord-006860-a3b8hyyr	945	25	alpha	alpha	NN
cord-006860-a3b8hyyr	945	26	-	-	HYPH
cord-006860-a3b8hyyr	945	27	factor	factor	NN
cord-006860-a3b8hyyr	945	28	XIIa	XIIa	NNS
cord-006860-a3b8hyyr	945	29	and	and	CC
cord-006860-a3b8hyyr	945	30	Bfactor	Bfactor	NNP
cord-006860-a3b8hyyr	945	31	XHa	XHa	NNP
cord-006860-a3b8hyyr	945	32	respectively	respectively	RB
cord-006860-a3b8hyyr	945	33	.	.	.
cord-006860-a3b8hyyr	946	1	All	all	DT
cord-006860-a3b8hyyr	946	2	ARDS	ARDS	NNP
cord-006860-a3b8hyyr	946	3	scores	score	NNS
cord-006860-a3b8hyyr	946	4	take	take	VBP
cord-006860-a3b8hyyr	946	5	the	the	DT
cord-006860-a3b8hyyr	946	6	PMN	pmn	NN
cord-006860-a3b8hyyr	946	7	-	-	HYPH
cord-006860-a3b8hyyr	946	8	elastase	elastase	NN
cord-006860-a3b8hyyr	946	9	into	into	IN
cord-006860-a3b8hyyr	946	10	account	account	NN
cord-006860-a3b8hyyr	946	11	.	.	.
cord-006860-a3b8hyyr	947	1	If	if	IN
cord-006860-a3b8hyyr	947	2	the	the	DT
cord-006860-a3b8hyyr	947	3	PMN	pmn	NN
cord-006860-a3b8hyyr	947	4	-	-	HYPH
cord-006860-a3b8hyyr	947	5	elastase	elastase	NN
cord-006860-a3b8hyyr	947	6	values	value	NNS
cord-006860-a3b8hyyr	947	7	(	(	-LRB-
cord-006860-a3b8hyyr	947	8	1000	1000	CD
cord-006860-a3b8hyyr	947	9	pg	pg	NN
cord-006860-a3b8hyyr	947	10	/	/	SYM
cord-006860-a3b8hyyr	947	11	l	l	NN
cord-006860-a3b8hyyr	947	12	)	)	-RRB-
cord-006860-a3b8hyyr	947	13	are	be	VBP
cord-006860-a3b8hyyr	947	14	constantly	constantly	RB
cord-006860-a3b8hyyr	947	15	high	high	JJ
cord-006860-a3b8hyyr	947	16	postoperatively	postoperatively	RB
cord-006860-a3b8hyyr	947	17	then	then	RB
cord-006860-a3b8hyyr	947	18	lung	lung	NN
cord-006860-a3b8hyyr	947	19	complications	complication	NNS
cord-006860-a3b8hyyr	947	20	are	be	VBP
cord-006860-a3b8hyyr	947	21	to	to	TO
cord-006860-a3b8hyyr	947	22	be	be	VB
cord-006860-a3b8hyyr	947	23	expected	expect	VBN
cord-006860-a3b8hyyr	947	24	.	.	.
cord-006860-a3b8hyyr	948	1	Patients	patient	NNS
cord-006860-a3b8hyyr	948	2	developing	develop	VBG
cord-006860-a3b8hyyr	948	3	an	an	DT
cord-006860-a3b8hyyr	948	4	ARDS	ARDS	NNP
cord-006860-a3b8hyyr	948	5	displayed	display	VBD
cord-006860-a3b8hyyr	948	6	significantly	significantly	RB
cord-006860-a3b8hyyr	948	7	lower	low	JJR
cord-006860-a3b8hyyr	948	8	alpha2-macroglobulin	alpha2-macroglobulin	JJ
cord-006860-a3b8hyyr	948	9	values	value	NNS
cord-006860-a3b8hyyr	948	10	.	.	.
cord-006860-a3b8hyyr	949	1	Patients	patient	NNS
cord-006860-a3b8hyyr	949	2	who	who	WP
cord-006860-a3b8hyyr	949	3	developed	develop	VBD
cord-006860-a3b8hyyr	949	4	a	a	DT
cord-006860-a3b8hyyr	949	5	highly	highly	RB
cord-006860-a3b8hyyr	949	6	significantly	significantly	RB
cord-006860-a3b8hyyr	949	7	raised	raise	VBN
cord-006860-a3b8hyyr	949	8	kallikrein	kallikrein	JJ
cord-006860-a3b8hyyr	949	9	-	-	HYPH
cord-006860-a3b8hyyr	949	10	like	like	JJ
cord-006860-a3b8hyyr	949	11	acdvity	acdvity	NN
cord-006860-a3b8hyyr	949	12	(	(	-LRB-
cord-006860-a3b8hyyr	949	13	>	>	NFP
cord-006860-a3b8hyyr	949	14	60	60	CD
cord-006860-a3b8hyyr	949	15	U	u	NN
cord-006860-a3b8hyyr	949	16	/	/	SYM
cord-006860-a3b8hyyr	949	17	I	i	NN
cord-006860-a3b8hyyr	949	18	)	)	-RRB-
cord-006860-a3b8hyyr	949	19	after	after	IN
cord-006860-a3b8hyyr	949	20	the	the	DT
cord-006860-a3b8hyyr	949	21	beginning	beginning	NN
cord-006860-a3b8hyyr	949	22	of	of	IN
cord-006860-a3b8hyyr	949	23	bypass	bypass	NN
cord-006860-a3b8hyyr	949	24	and	and	CC
cord-006860-a3b8hyyr	949	25	showed	show	VBD
cord-006860-a3b8hyyr	949	26	constantly	constantly	RB
cord-006860-a3b8hyyr	949	27	high	high	JJ
cord-006860-a3b8hyyr	949	28	values	value	NNS
cord-006860-a3b8hyyr	949	29	during	during	IN
cord-006860-a3b8hyyr	949	30	ECC	ECC	NNP
cord-006860-a3b8hyyr	949	31	are	be	VBP
cord-006860-a3b8hyyr	949	32	difficult	difficult	JJ
cord-006860-a3b8hyyr	949	33	to	to	TO
cord-006860-a3b8hyyr	949	34	keep	keep	VB
cord-006860-a3b8hyyr	949	35	under	under	IN
cord-006860-a3b8hyyr	949	36	control	control	NN
cord-006860-a3b8hyyr	949	37	due	due	IN
cord-006860-a3b8hyyr	949	38	to	to	IN
cord-006860-a3b8hyyr	949	39	the	the	DT
cord-006860-a3b8hyyr	949	40	blood	blood	NN
cord-006860-a3b8hyyr	949	41	pressure	pressure	NN
cord-006860-a3b8hyyr	949	42	behaviour	behaviour	NN
cord-006860-a3b8hyyr	949	43	.	.	.
cord-006860-a3b8hyyr	950	1	The	the	DT
cord-006860-a3b8hyyr	950	2	platelet	platelet	NN
cord-006860-a3b8hyyr	950	3	PAl	PAl	NNS
cord-006860-a3b8hyyr	950	4	also	also	RB
cord-006860-a3b8hyyr	950	5	shows	show	VBZ
cord-006860-a3b8hyyr	950	6	a	a	DT
cord-006860-a3b8hyyr	950	7	significant	significant	JJ
cord-006860-a3b8hyyr	950	8	rise	rise	NN
cord-006860-a3b8hyyr	950	9	and	and	CC
cord-006860-a3b8hyyr	950	10	intraoperatively	intraoperatively	NN
cord-006860-a3b8hyyr	950	11	runs	run	VBZ
cord-006860-a3b8hyyr	950	12	analogous	analogous	JJ
cord-006860-a3b8hyyr	950	13	to	to	IN
cord-006860-a3b8hyyr	950	14	platelet	platelet	NN
cord-006860-a3b8hyyr	950	15	factor	factor	NN
cord-006860-a3b8hyyr	950	16	4	4	CD
cord-006860-a3b8hyyr	950	17	,	,	,
cord-006860-a3b8hyyr	950	18	only	only	RB
cord-006860-a3b8hyyr	950	19	antiparailel	antiparailel	NNS
cord-006860-a3b8hyyr	950	20	,	,	,
cord-006860-a3b8hyyr	950	21	since	since	IN
cord-006860-a3b8hyyr	950	22	it	-PRON-	PRP
cord-006860-a3b8hyyr	950	23	attacks	attack	VBZ
cord-006860-a3b8hyyr	950	24	the	the	DT
cord-006860-a3b8hyyr	950	25	endothelium	endothelium	NN
cord-006860-a3b8hyyr	950	26	.	.	.
cord-006860-a3b8hyyr	951	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	951	2	were	be	VBD
cord-006860-a3b8hyyr	951	3	able	able	JJ
cord-006860-a3b8hyyr	951	4	to	to	TO
cord-006860-a3b8hyyr	951	5	show	show	VB
cord-006860-a3b8hyyr	951	6	that	that	IN
cord-006860-a3b8hyyr	951	7	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	951	8	is	be	VBZ
cord-006860-a3b8hyyr	951	9	suitable	suitable	JJ
cord-006860-a3b8hyyr	951	10	as	as	IN
cord-006860-a3b8hyyr	951	11	an	an	DT
cord-006860-a3b8hyyr	951	12	indirect	indirect	JJ
cord-006860-a3b8hyyr	951	13	marker	marker	NN
cord-006860-a3b8hyyr	951	14	for	for	IN
cord-006860-a3b8hyyr	951	15	a	a	DT
cord-006860-a3b8hyyr	951	16	possibly	possibly	RB
cord-006860-a3b8hyyr	951	17	developing	develop	VBG
cord-006860-a3b8hyyr	951	18	restenosis	restenosis	NN
cord-006860-a3b8hyyr	951	19	.	.	.
cord-006860-a3b8hyyr	952	1	85	85	CD
cord-006860-a3b8hyyr	952	2	%	%	NN
cord-006860-a3b8hyyr	952	3	of	of	IN
cord-006860-a3b8hyyr	952	4	the	the	DT
cord-006860-a3b8hyyr	952	5	patients	patient	NNS
cord-006860-a3b8hyyr	952	6	investigated	investigate	VBN
cord-006860-a3b8hyyr	952	7	with	with	IN
cord-006860-a3b8hyyr	952	8	lowered	lower	VBN
cord-006860-a3b8hyyr	952	9	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	952	10	values	value	NNS
cord-006860-a3b8hyyr	952	11	in	in	IN
cord-006860-a3b8hyyr	952	12	the	the	DT
cord-006860-a3b8hyyr	952	13	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	952	14	phase	phase	NN
cord-006860-a3b8hyyr	952	15	did	do	VBD
cord-006860-a3b8hyyr	952	16	not	not	RB
cord-006860-a3b8hyyr	952	17	develop	develop	VB
cord-006860-a3b8hyyr	952	18	a	a	DT
cord-006860-a3b8hyyr	952	19	restenosis	restenosis	NN
cord-006860-a3b8hyyr	952	20	.	.	.
cord-006860-a3b8hyyr	953	1	However	however	RB
cord-006860-a3b8hyyr	953	2	,	,	,
cord-006860-a3b8hyyr	953	3	with	with	IN
cord-006860-a3b8hyyr	953	4	patients	patient	NNS
cord-006860-a3b8hyyr	953	5	showing	show	VBG
cord-006860-a3b8hyyr	953	6	significantly	significantly	RB
cord-006860-a3b8hyyr	953	7	rising	rise	VBG
cord-006860-a3b8hyyr	953	8	PA[-1	PA[-1	NNP
cord-006860-a3b8hyyr	953	9	values	value	NNS
cord-006860-a3b8hyyr	953	10	from	from	IN
cord-006860-a3b8hyyr	953	11	the	the	DT
cord-006860-a3b8hyyr	953	12	1	1	CD
cord-006860-a3b8hyyr	953	13	st	st	NNP
cord-006860-a3b8hyyr	953	14	.	.	NNP
cord-006860-a3b8hyyr	953	15	to	to	IN
cord-006860-a3b8hyyr	953	16	3rd	3rd	NN
cord-006860-a3b8hyyr	953	17	.	.	.
cord-006860-a3b8hyyr	954	1	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	954	2	day	day	NN
cord-006860-a3b8hyyr	954	3	50	50	CD
cord-006860-a3b8hyyr	954	4	%	%	NN
cord-006860-a3b8hyyr	954	5	of	of	IN
cord-006860-a3b8hyyr	954	6	all	all	PDT
cord-006860-a3b8hyyr	954	7	the	the	DT
cord-006860-a3b8hyyr	954	8	cases	case	NNS
cord-006860-a3b8hyyr	954	9	had	have	VBD
cord-006860-a3b8hyyr	954	10	a	a	DT
cord-006860-a3b8hyyr	954	11	restenosis	restenosis	NN
cord-006860-a3b8hyyr	954	12	.	.	.
cord-006860-a3b8hyyr	955	1	A	a	DT
cord-006860-a3b8hyyr	955	2	further	further	JJ
cord-006860-a3b8hyyr	955	3	risk	risk	NN
cord-006860-a3b8hyyr	955	4	factor	factor	NN
cord-006860-a3b8hyyr	955	5	in	in	IN
cord-006860-a3b8hyyr	955	6	this	this	DT
cord-006860-a3b8hyyr	955	7	respect	respect	NN
cord-006860-a3b8hyyr	955	8	are	be	VBP
cord-006860-a3b8hyyr	955	9	significantly	significantly	RB
cord-006860-a3b8hyyr	955	10	raised	raise	VBN
cord-006860-a3b8hyyr	955	11	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	955	12	levels	level	NNS
cord-006860-a3b8hyyr	955	13	which	which	WDT
cord-006860-a3b8hyyr	955	14	lay	lie	VBD
cord-006860-a3b8hyyr	955	15	over	over	IN
cord-006860-a3b8hyyr	955	16	800	800	CD
cord-006860-a3b8hyyr	955	17	%	%	NN
cord-006860-a3b8hyyr	955	18	at	at	IN
cord-006860-a3b8hyyr	955	19	the	the	DT
cord-006860-a3b8hyyr	955	20	end	end	NN
cord-006860-a3b8hyyr	955	21	of	of	IN
cord-006860-a3b8hyyr	955	22	surgery	surgery	NN
cord-006860-a3b8hyyr	955	23	.	.	.
cord-006860-a3b8hyyr	956	1	If	if	IN
cord-006860-a3b8hyyr	956	2	these	these	DT
cord-006860-a3b8hyyr	956	3	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	956	4	values	value	NNS
cord-006860-a3b8hyyr	956	5	do	do	VBP
cord-006860-a3b8hyyr	956	6	not	not	RB
cord-006860-a3b8hyyr	956	7	fall	fall	VB
cord-006860-a3b8hyyr	956	8	from	from	IN
cord-006860-a3b8hyyr	956	9	the	the	DT
cord-006860-a3b8hyyr	956	10	1st	1st	NN
cord-006860-a3b8hyyr	956	11	.	.	.
cord-006860-a3b8hyyr	957	1	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	957	2	day	day	NN
cord-006860-a3b8hyyr	957	3	onwards	onwards	RB
cord-006860-a3b8hyyr	957	4	a	a	DT
cord-006860-a3b8hyyr	957	5	raised	raise	VBN
cord-006860-a3b8hyyr	957	6	risk	risk	NN
cord-006860-a3b8hyyr	957	7	of	of	IN
cord-006860-a3b8hyyr	957	8	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	957	9	must	must	MD
cord-006860-a3b8hyyr	957	10	be	be	VB
cord-006860-a3b8hyyr	957	11	reckoned	reckon	VBN
cord-006860-a3b8hyyr	957	12	with	with	IN
cord-006860-a3b8hyyr	957	13	in	in	IN
cord-006860-a3b8hyyr	957	14	the	the	DT
cord-006860-a3b8hyyr	957	15	absence	absence	NN
cord-006860-a3b8hyyr	957	16	of	of	IN
cord-006860-a3b8hyyr	957	17	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	957	18	intervention	intervention	NN
cord-006860-a3b8hyyr	957	19	.	.	.
cord-006860-a3b8hyyr	958	1	The	the	DT
cord-006860-a3b8hyyr	958	2	following	following	JJ
cord-006860-a3b8hyyr	958	3	parameters	parameter	NNS
cord-006860-a3b8hyyr	958	4	represented	represent	VBD
cord-006860-a3b8hyyr	958	5	haemostaseological	haemostaseological	JJ
cord-006860-a3b8hyyr	958	6	risk	risk	NN
cord-006860-a3b8hyyr	958	7	parameters	parameter	NNS
cord-006860-a3b8hyyr	958	8	with	with	IN
cord-006860-a3b8hyyr	958	9	significant	significant	JJ
cord-006860-a3b8hyyr	958	10	behaviour	behaviour	NN
cord-006860-a3b8hyyr	958	11	within	within	IN
cord-006860-a3b8hyyr	958	12	the	the	DT
cord-006860-a3b8hyyr	958	13	framework	framework	NN
cord-006860-a3b8hyyr	958	14	of	of	IN
cord-006860-a3b8hyyr	958	15	this	this	DT
cord-006860-a3b8hyyr	958	16	study	study	NN
cord-006860-a3b8hyyr	958	17	:	:	:
cord-006860-a3b8hyyr	958	18	1	1	LS
cord-006860-a3b8hyyr	958	19	)	)	-RRB-
cord-006860-a3b8hyyr	958	20	regards	regard	VBZ
cord-006860-a3b8hyyr	958	21	the	the	DT
cord-006860-a3b8hyyr	958	22	blood	blood	NN
cord-006860-a3b8hyyr	958	23	pressure	pressure	NN
cord-006860-a3b8hyyr	958	24	behaviour	behaviour	NN
cord-006860-a3b8hyyr	958	25	,	,	,
cord-006860-a3b8hyyr	958	26	the	the	DT
cord-006860-a3b8hyyr	958	27	kallikrein	kallikrein	NN
cord-006860-a3b8hyyr	958	28	-	-	HYPH
cord-006860-a3b8hyyr	958	29	like	like	JJ
cord-006860-a3b8hyyr	958	30	activity	activity	NN
cord-006860-a3b8hyyr	958	31	(	(	-LRB-
cord-006860-a3b8hyyr	958	32	>	>	SYM
cord-006860-a3b8hyyr	958	33	60	60	CD
cord-006860-a3b8hyyr	958	34	U	u	NN
cord-006860-a3b8hyyr	958	35	/	/	SYM
cord-006860-a3b8hyyr	958	36	I	i	NN
cord-006860-a3b8hyyr	958	37	)	)	-RRB-
cord-006860-a3b8hyyr	958	38	;	;	:
cord-006860-a3b8hyyr	958	39	2	2	LS
cord-006860-a3b8hyyr	958	40	)	)	-RRB-
cord-006860-a3b8hyyr	958	41	with	with	IN
cord-006860-a3b8hyyr	958	42	regards	regard	NNS
cord-006860-a3b8hyyr	958	43	to	to	IN
cord-006860-a3b8hyyr	958	44	the	the	DT
cord-006860-a3b8hyyr	958	45	lung	lung	NN
cord-006860-a3b8hyyr	958	46	complications	complication	NNS
cord-006860-a3b8hyyr	958	47	,	,	,
cord-006860-a3b8hyyr	958	48	aipha2-macroglobulin	aipha2-macroglobulin	NNP
cord-006860-a3b8hyyr	958	49	and	and	CC
cord-006860-a3b8hyyr	958	50	PMN	pmn	NN
cord-006860-a3b8hyyr	958	51	-	-	HYPH
cord-006860-a3b8hyyr	958	52	elastase	elastase	NN
cord-006860-a3b8hyyr	958	53	(	(	-LRB-
cord-006860-a3b8hyyr	958	54	>	>	NFP
cord-006860-a3b8hyyr	958	55	900	900	CD
cord-006860-a3b8hyyr	958	56	g	g	NN
cord-006860-a3b8hyyr	958	57	/	/	SYM
cord-006860-a3b8hyyr	958	58	i	i	NN
cord-006860-a3b8hyyr	958	59	)	)	-RRB-
cord-006860-a3b8hyyr	958	60	;	;	:
cord-006860-a3b8hyyr	958	61	3	3	LS
cord-006860-a3b8hyyr	958	62	)	)	-RRB-
cord-006860-a3b8hyyr	958	63	and	and	CC
cord-006860-a3b8hyyr	958	64	final	final	JJ
cord-006860-a3b8hyyr	958	65	/	/	SYM
cord-006860-a3b8hyyr	958	66	y	y	NN
cord-006860-a3b8hyyr	958	67	as	as	IN
cord-006860-a3b8hyyr	958	68	a	a	DT
cord-006860-a3b8hyyr	958	69	possible	possible	JJ
cord-006860-a3b8hyyr	958	70	marker	marker	NN
cord-006860-a3b8hyyr	958	71	for	for	IN
cord-006860-a3b8hyyr	958	72	a	a	DT
cord-006860-a3b8hyyr	958	73	developing	develop	VBG
cord-006860-a3b8hyyr	958	74	restenosis	restenosis	NN
cord-006860-a3b8hyyr	958	75	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	958	76	and	and	CC
cord-006860-a3b8hyyr	958	77	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	958	78	(	(	-LRB-
cord-006860-a3b8hyyr	958	79	>	>	NFP
cord-006860-a3b8hyyr	958	80	800	800	CD
cord-006860-a3b8hyyr	958	81	%	%	NN
cord-006860-a3b8hyyr	958	82	)	)	-RRB-
cord-006860-a3b8hyyr	958	83	.	.	.
cord-006860-a3b8hyyr	959	1	Resulting	result	VBG
cord-006860-a3b8hyyr	959	2	from	from	IN
cord-006860-a3b8hyyr	959	3	numerous	numerous	JJ
cord-006860-a3b8hyyr	959	4	clinical	clinical	JJ
cord-006860-a3b8hyyr	959	5	studies	study	NNS
cord-006860-a3b8hyyr	959	6	homocysteinemia	homocysteinemia	NN
cord-006860-a3b8hyyr	959	7	is	be	VBZ
cord-006860-a3b8hyyr	959	8	found	find	VBN
cord-006860-a3b8hyyr	959	9	to	to	TO
cord-006860-a3b8hyyr	959	10	be	be	VB
cord-006860-a3b8hyyr	959	11	an	an	DT
cord-006860-a3b8hyyr	959	12	almost	almost	RB
cord-006860-a3b8hyyr	959	13	independent	independent	JJ
cord-006860-a3b8hyyr	959	14	risk	risk	NN
cord-006860-a3b8hyyr	959	15	factor	factor	NN
cord-006860-a3b8hyyr	959	16	of	of	IN
cord-006860-a3b8hyyr	959	17	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	959	18	including	include	VBG
cord-006860-a3b8hyyr	959	19	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	959	20	complications	complication	NNS
cord-006860-a3b8hyyr	959	21	as	as	RB
cord-006860-a3b8hyyr	959	22	well	well	RB
cord-006860-a3b8hyyr	959	23	as	as	IN
cord-006860-a3b8hyyr	959	24	of	of	IN
cord-006860-a3b8hyyr	959	25	venous	venous	JJ
cord-006860-a3b8hyyr	959	26	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	959	27	.	.	.
cord-006860-a3b8hyyr	960	1	Experimental	experimental	JJ
cord-006860-a3b8hyyr	960	2	investigations	investigation	NNS
cord-006860-a3b8hyyr	960	3	on	on	IN
cord-006860-a3b8hyyr	960	4	the	the	DT
cord-006860-a3b8hyyr	960	5	underlying	underlie	VBG
cord-006860-a3b8hyyr	960	6	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	960	7	suggest	suggest	VBP
cord-006860-a3b8hyyr	960	8	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	960	9	cell	cell	NN
cord-006860-a3b8hyyr	960	10	damage	damage	NN
cord-006860-a3b8hyyr	960	11	accompartied	accompartie	VBN
cord-006860-a3b8hyyr	960	12	by	by	IN
cord-006860-a3b8hyyr	960	13	the	the	DT
cord-006860-a3b8hyyr	960	14	development	development	NN
cord-006860-a3b8hyyr	960	15	of	of	IN
cord-006860-a3b8hyyr	960	16	an	an	DT
cord-006860-a3b8hyyr	960	17	atherogenic	atherogenic	JJ
cord-006860-a3b8hyyr	960	18	and	and	CC
cord-006860-a3b8hyyr	960	19	thrombogenic	thrombogenic	JJ
cord-006860-a3b8hyyr	960	20	potential	potential	NN
cord-006860-a3b8hyyr	960	21	,	,	,
cord-006860-a3b8hyyr	960	22	increased	increase	VBN
cord-006860-a3b8hyyr	960	23	platelet	platelet	NN
cord-006860-a3b8hyyr	960	24	reactivity	reactivity	NN
cord-006860-a3b8hyyr	960	25	,	,	,
cord-006860-a3b8hyyr	960	26	oxidative	oxidative	JJ
cord-006860-a3b8hyyr	960	27	modification	modification	NN
cord-006860-a3b8hyyr	960	28	of	of	IN
cord-006860-a3b8hyyr	960	29	LDL	ldl	NN
cord-006860-a3b8hyyr	960	30	,	,	,
cord-006860-a3b8hyyr	960	31	and	and	CC
cord-006860-a3b8hyyr	960	32	enhanced	enhanced	JJ
cord-006860-a3b8hyyr	960	33	affinity	affinity	NN
cord-006860-a3b8hyyr	960	34	of	of	IN
cord-006860-a3b8hyyr	960	35	Lp(a	Lp(a	NNP
cord-006860-a3b8hyyr	960	36	)	)	-RRB-
cord-006860-a3b8hyyr	960	37	for	for	IN
cord-006860-a3b8hyyr	960	38	fibrin	fibrin	NN
cord-006860-a3b8hyyr	960	39	.	.	.
cord-006860-a3b8hyyr	961	1	To	to	IN
cord-006860-a3b8hyyr	961	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	961	3	knowledge	knowledge	NN
cord-006860-a3b8hyyr	961	4	no	no	DT
cord-006860-a3b8hyyr	961	5	results	result	NNS
cord-006860-a3b8hyyr	961	6	are	be	VBP
cord-006860-a3b8hyyr	961	7	published	publish	VBN
cord-006860-a3b8hyyr	961	8	on	on	IN
cord-006860-a3b8hyyr	961	9	the	the	DT
cord-006860-a3b8hyyr	961	10	influence	influence	NN
cord-006860-a3b8hyyr	961	11	of	of	IN
cord-006860-a3b8hyyr	961	12	homoeysteine	homoeysteine	NN
cord-006860-a3b8hyyr	961	13	on	on	IN
cord-006860-a3b8hyyr	961	14	leukoeytes	leukoeytes	NNP
cord-006860-a3b8hyyr	961	15	although	although	IN
cord-006860-a3b8hyyr	961	16	these	these	DT
cord-006860-a3b8hyyr	961	17	cells	cell	NNS
cord-006860-a3b8hyyr	961	18	are	be	VBP
cord-006860-a3b8hyyr	961	19	deeply	deeply	RB
cord-006860-a3b8hyyr	961	20	involved	involved	JJ
cord-006860-a3b8hyyr	961	21	in	in	IN
cord-006860-a3b8hyyr	961	22	pathological	pathological	JJ
cord-006860-a3b8hyyr	961	23	events	event	NNS
cord-006860-a3b8hyyr	961	24	within	within	IN
cord-006860-a3b8hyyr	961	25	the	the	DT
cord-006860-a3b8hyyr	961	26	vasculature	vasculature	NN
cord-006860-a3b8hyyr	961	27	.	.	.
cord-006860-a3b8hyyr	962	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	962	2	,	,	,
cord-006860-a3b8hyyr	962	3	as	as	IN
cord-006860-a3b8hyyr	962	4	a	a	DT
cord-006860-a3b8hyyr	962	5	first	first	JJ
cord-006860-a3b8hyyr	962	6	approach	approach	NN
cord-006860-a3b8hyyr	962	7	different	different	JJ
cord-006860-a3b8hyyr	962	8	functional	functional	JJ
cord-006860-a3b8hyyr	962	9	parameters	parameter	NNS
cord-006860-a3b8hyyr	962	10	of	of	IN
cord-006860-a3b8hyyr	962	11	human	human	JJ
cord-006860-a3b8hyyr	962	12	polymorphonuclear	polymorphonuclear	FW
cord-006860-a3b8hyyr	962	13	leukozytes	leukozyte	NNS
cord-006860-a3b8hyyr	962	14	(	(	-LRB-
cord-006860-a3b8hyyr	962	15	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	962	16	)	)	-RRB-
cord-006860-a3b8hyyr	962	17	were	be	VBD
cord-006860-a3b8hyyr	962	18	followed	follow	VBN
cord-006860-a3b8hyyr	962	19	under	under	IN
cord-006860-a3b8hyyr	962	20	incubation	incubation	NN
cord-006860-a3b8hyyr	962	21	with	with	IN
cord-006860-a3b8hyyr	962	22	60	60	CD
cord-006860-a3b8hyyr	962	23	,	,	,
cord-006860-a3b8hyyr	962	24	300	300	CD
cord-006860-a3b8hyyr	962	25	,	,	,
cord-006860-a3b8hyyr	962	26	and	and	CC
cord-006860-a3b8hyyr	962	27	600	600	CD
cord-006860-a3b8hyyr	962	28	I.tM	i.tm	NN
cord-006860-a3b8hyyr	962	29	(	(	-LRB-
cord-006860-a3b8hyyr	962	30	final	final	JJ
cord-006860-a3b8hyyr	962	31	concentration	concentration	NN
cord-006860-a3b8hyyr	962	32	)	)	-RRB-
cord-006860-a3b8hyyr	962	33	DL	dl	NN
cord-006860-a3b8hyyr	962	34	-	-	HYPH
cord-006860-a3b8hyyr	962	35	homocysteine	homocysteine	JJ
cord-006860-a3b8hyyr	962	36	(	(	-LRB-
cord-006860-a3b8hyyr	962	37	HC	HC	NNP
cord-006860-a3b8hyyr	962	38	)	)	-RRB-
cord-006860-a3b8hyyr	962	39	in	in	IN
cord-006860-a3b8hyyr	962	40	isolated	isolated	JJ
cord-006860-a3b8hyyr	962	41	fractions	fraction	NNS
cord-006860-a3b8hyyr	962	42	or	or	CC
cord-006860-a3b8hyyr	962	43	whole	whole	JJ
cord-006860-a3b8hyyr	962	44	blood	blood	NN
cord-006860-a3b8hyyr	962	45	,	,	,
cord-006860-a3b8hyyr	962	46	respectively	respectively	RB
cord-006860-a3b8hyyr	963	1	:	:	:
cord-006860-a3b8hyyr	963	2	l	l	LS
cord-006860-a3b8hyyr	963	3	)	)	-RRB-
cord-006860-a3b8hyyr	963	4	Spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	963	5	mobility	mobility	NN
cord-006860-a3b8hyyr	963	6	of	of	IN
cord-006860-a3b8hyyr	963	7	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	963	8	,	,	,
cord-006860-a3b8hyyr	963	9	measured	measure	VBN
cord-006860-a3b8hyyr	963	10	as	as	IN
cord-006860-a3b8hyyr	963	11	migration	migration	NN
cord-006860-a3b8hyyr	963	12	distance	distance	NN
cord-006860-a3b8hyyr	963	13	into	into	IN
cord-006860-a3b8hyyr	963	14	micropore	micropore	NN
cord-006860-a3b8hyyr	963	15	filters	filter	NNS
cord-006860-a3b8hyyr	963	16	in	in	IN
cord-006860-a3b8hyyr	963	17	a	a	DT
cord-006860-a3b8hyyr	963	18	modified	modify	VBN
cord-006860-a3b8hyyr	963	19	Boyden	Boyden	NNP
cord-006860-a3b8hyyr	963	20	-	-	HYPH
cord-006860-a3b8hyyr	963	21	chamber	chamber	NNP
cord-006860-a3b8hyyr	963	22	,	,	,
cord-006860-a3b8hyyr	963	23	is	be	VBZ
cord-006860-a3b8hyyr	963	24	found	find	VBN
cord-006860-a3b8hyyr	963	25	to	to	TO
cord-006860-a3b8hyyr	963	26	be	be	VB
cord-006860-a3b8hyyr	963	27	significantly	significantly	RB
cord-006860-a3b8hyyr	963	28	enhanced	enhance	VBN
cord-006860-a3b8hyyr	963	29	by	by	IN
cord-006860-a3b8hyyr	963	30	the	the	DT
cord-006860-a3b8hyyr	963	31	two	two	CD
cord-006860-a3b8hyyr	963	32	smaller	small	JJR
cord-006860-a3b8hyyr	963	33	HC	HC	NNP
cord-006860-a3b8hyyr	963	34	concentrations	concentration	NNS
cord-006860-a3b8hyyr	963	35	.	.	.
cord-006860-a3b8hyyr	964	1	2	2	LS
cord-006860-a3b8hyyr	964	2	)	)	-RRB-
cord-006860-a3b8hyyr	964	3	Chemotaxis	Chemotaxis	NNP
cord-006860-a3b8hyyr	964	4	induced	induce	VBN
cord-006860-a3b8hyyr	964	5	by	by	IN
cord-006860-a3b8hyyr	964	6	0.1	0.1	CD
cord-006860-a3b8hyyr	964	7	I.tM	I.tM	NNP
cord-006860-a3b8hyyr	964	8	formylmethionylleueylphenylaianine	formylmethionylleueylphenylaianine	NNP
cord-006860-a3b8hyyr	964	9	(	(	-LRB-
cord-006860-a3b8hyyr	964	10	tMLP	tMLP	NNP
cord-006860-a3b8hyyr	964	11	)	)	-RRB-
cord-006860-a3b8hyyr	964	12	shows	show	VBZ
cord-006860-a3b8hyyr	964	13	no	no	DT
cord-006860-a3b8hyyr	964	14	significant	significant	JJ
cord-006860-a3b8hyyr	964	15	differences	difference	NNS
cord-006860-a3b8hyyr	964	16	.	.	.
cord-006860-a3b8hyyr	965	1	3)Monitoring	3)monitore	VBG
cord-006860-a3b8hyyr	965	2	of	of	IN
cord-006860-a3b8hyyr	965	3	chemiluminescence	chemiluminescence	NN
cord-006860-a3b8hyyr	965	4	signals	signal	NNS
cord-006860-a3b8hyyr	965	5	(	(	-LRB-
cord-006860-a3b8hyyr	965	6	AutoLumat	AutoLumat	NNP
cord-006860-a3b8hyyr	965	7	LB953	LB953	VBZ
cord-006860-a3b8hyyr	965	8	,	,	,
cord-006860-a3b8hyyr	965	9	Berthold	Berthold	NNP
cord-006860-a3b8hyyr	965	10	)	)	-RRB-
cord-006860-a3b8hyyr	965	11	is	be	VBZ
cord-006860-a3b8hyyr	965	12	complicated	complicate	VBN
cord-006860-a3b8hyyr	965	13	as	as	IN
cord-006860-a3b8hyyr	965	14	HC	HC	NNP
cord-006860-a3b8hyyr	965	15	influences	influence	VBZ
cord-006860-a3b8hyyr	965	16	the	the	DT
cord-006860-a3b8hyyr	965	17	luminol	luminol	RB
cord-006860-a3b8hyyr	965	18	-	-	HYPH
cord-006860-a3b8hyyr	965	19	mediated	mediate	VBN
cord-006860-a3b8hyyr	965	20	indicator	indicator	NN
cord-006860-a3b8hyyr	965	21	reaction	reaction	NN
cord-006860-a3b8hyyr	965	22	.	.	.
cord-006860-a3b8hyyr	966	1	Adjusting	adjust	VBG
cord-006860-a3b8hyyr	966	2	appropriate	appropriate	JJ
cord-006860-a3b8hyyr	966	3	conditions	condition	NNS
cord-006860-a3b8hyyr	966	4	the	the	DT
cord-006860-a3b8hyyr	966	5	following	follow	VBG
cord-006860-a3b8hyyr	966	6	results	result	NNS
cord-006860-a3b8hyyr	966	7	are	be	VBP
cord-006860-a3b8hyyr	966	8	obtained	obtain	VBN
cord-006860-a3b8hyyr	966	9	:	:	:
cord-006860-a3b8hyyr	966	10	Spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	966	11	chemiluminescence	chemiluminescence	NN
cord-006860-a3b8hyyr	966	12	and	and	CC
cord-006860-a3b8hyyr	967	1	that	that	DT
cord-006860-a3b8hyyr	967	2	induced	induce	VBN
cord-006860-a3b8hyyr	967	3	by	by	IN
cord-006860-a3b8hyyr	967	4	zymosane	zymosane	NNP
cord-006860-a3b8hyyr	967	5	,	,	,
cord-006860-a3b8hyyr	967	6	tMLP	tMLP	NNP
cord-006860-a3b8hyyr	967	7	,	,	,
cord-006860-a3b8hyyr	967	8	and	and	CC
cord-006860-a3b8hyyr	967	9	the	the	DT
cord-006860-a3b8hyyr	967	10	Ca2	Ca2	NNP
cord-006860-a3b8hyyr	968	1	+	+	CC
cord-006860-a3b8hyyr	969	1	-ionophore	-ionophore	:
cord-006860-a3b8hyyr	969	2	A23187	A23187	NNP
cord-006860-a3b8hyyr	969	3	are	be	VBP
cord-006860-a3b8hyyr	969	4	entranced	entrance	VBN
cord-006860-a3b8hyyr	969	5	by	by	IN
cord-006860-a3b8hyyr	969	6	the	the	DT
cord-006860-a3b8hyyr	969	7	two	two	CD
cord-006860-a3b8hyyr	969	8	higher	high	JJR
cord-006860-a3b8hyyr	969	9	HC	HC	NNP
cord-006860-a3b8hyyr	969	10	concentrations	concentration	NNS
cord-006860-a3b8hyyr	969	11	.	.	.
cord-006860-a3b8hyyr	970	1	There	there	EX
cord-006860-a3b8hyyr	970	2	are	be	VBP
cord-006860-a3b8hyyr	970	3	,	,	,
cord-006860-a3b8hyyr	970	4	however	however	RB
cord-006860-a3b8hyyr	970	5	,	,	,
cord-006860-a3b8hyyr	970	6	differences	difference	NNS
cord-006860-a3b8hyyr	970	7	between	between	IN
cord-006860-a3b8hyyr	970	8	the	the	DT
cord-006860-a3b8hyyr	970	9	blood	blood	NN
cord-006860-a3b8hyyr	970	10	donors	donor	NNS
cord-006860-a3b8hyyr	970	11	as	as	IN
cord-006860-a3b8hyyr	970	12	a	a	DT
cord-006860-a3b8hyyr	970	13	minority	minority	NN
cord-006860-a3b8hyyr	970	14	does	do	VBZ
cord-006860-a3b8hyyr	970	15	not	not	RB
cord-006860-a3b8hyyr	970	16	respond	respond	VB
cord-006860-a3b8hyyr	970	17	to	to	IN
cord-006860-a3b8hyyr	970	18	HC	HC	NNP
cord-006860-a3b8hyyr	970	19	in	in	IN
cord-006860-a3b8hyyr	970	20	repeated	repeat	VBN
cord-006860-a3b8hyyr	970	21	measurements	measurement	NNS
cord-006860-a3b8hyyr	970	22	.	.	.
cord-006860-a3b8hyyr	971	1	With	with	IN
cord-006860-a3b8hyyr	971	2	phorbol	phorbol	NN
cord-006860-a3b8hyyr	971	3	12-myristate	12-myristate	CD
cord-006860-a3b8hyyr	971	4	13	13	CD
cord-006860-a3b8hyyr	971	5	acetate	acetate	NN
cord-006860-a3b8hyyr	971	6	the	the	DT
cord-006860-a3b8hyyr	971	7	signal	signal	NN
cord-006860-a3b8hyyr	971	8	is	be	VBZ
cord-006860-a3b8hyyr	971	9	diminished	diminish	VBN
cord-006860-a3b8hyyr	971	10	by	by	IN
cord-006860-a3b8hyyr	971	11	HC	HC	NNP
cord-006860-a3b8hyyr	971	12	in	in	IN
cord-006860-a3b8hyyr	971	13	all	all	DT
cord-006860-a3b8hyyr	971	14	cases	case	NNS
cord-006860-a3b8hyyr	971	15	and	and	CC
cord-006860-a3b8hyyr	971	16	with	with	IN
cord-006860-a3b8hyyr	971	17	all	all	DT
cord-006860-a3b8hyyr	971	18	concentrations	concentration	NNS
cord-006860-a3b8hyyr	971	19	.	.	.
cord-006860-a3b8hyyr	972	1	4	4	LS
cord-006860-a3b8hyyr	972	2	)	)	-RRB-
cord-006860-a3b8hyyr	972	3	Phagoeytosis	Phagoeytosis	NNP
cord-006860-a3b8hyyr	972	4	induced	induce	VBN
cord-006860-a3b8hyyr	972	5	by	by	IN
cord-006860-a3b8hyyr	972	6	zymosane	zymosane	NNP
cord-006860-a3b8hyyr	972	7	(	(	-LRB-
cord-006860-a3b8hyyr	972	8	microscopic	microscopic	JJ
cord-006860-a3b8hyyr	972	9	evaluation	evaluation	NN
cord-006860-a3b8hyyr	972	10	)	)	-RRB-
cord-006860-a3b8hyyr	972	11	as	as	RB
cord-006860-a3b8hyyr	972	12	well	well	RB
cord-006860-a3b8hyyr	972	13	as	as	IN
cord-006860-a3b8hyyr	972	14	by	by	IN
cord-006860-a3b8hyyr	972	15	opsonized	opsonize	VBN
cord-006860-a3b8hyyr	972	16	E.	E.	NNP
cord-006860-a3b8hyyr	972	17	coil	coil	NNP
cord-006860-a3b8hyyr	972	18	(	(	-LRB-
cord-006860-a3b8hyyr	972	19	cytoflowmetric	cytoflowmetric	JJ
cord-006860-a3b8hyyr	972	20	evaluation	evaluation	NN
cord-006860-a3b8hyyr	972	21	)	)	-RRB-
cord-006860-a3b8hyyr	973	1	is	be	VBZ
cord-006860-a3b8hyyr	973	2	significantly	significantly	RB
cord-006860-a3b8hyyr	973	3	increased	increase	VBN
cord-006860-a3b8hyyr	973	4	by	by	IN
cord-006860-a3b8hyyr	973	5	the	the	DT
cord-006860-a3b8hyyr	973	6	two	two	CD
cord-006860-a3b8hyyr	973	7	higher	high	JJR
cord-006860-a3b8hyyr	973	8	HC	HC	NNP
cord-006860-a3b8hyyr	973	9	concentrations	concentration	NNS
cord-006860-a3b8hyyr	973	10	.	.	.
cord-006860-a3b8hyyr	974	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	974	2	:	:	:
cord-006860-a3b8hyyr	975	1	The	the	DT
cord-006860-a3b8hyyr	975	2	activation	activation	NN
cord-006860-a3b8hyyr	975	3	of	of	IN
cord-006860-a3b8hyyr	975	4	human	human	JJ
cord-006860-a3b8hyyr	975	5	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	975	6	is	be	VBZ
cord-006860-a3b8hyyr	975	7	enhanced	enhance	VBN
cord-006860-a3b8hyyr	975	8	with	with	IN
cord-006860-a3b8hyyr	975	9	respect	respect	NN
cord-006860-a3b8hyyr	975	10	to	to	IN
cord-006860-a3b8hyyr	975	11	the	the	DT
cord-006860-a3b8hyyr	975	12	majority	majority	NN
cord-006860-a3b8hyyr	975	13	of	of	IN
cord-006860-a3b8hyyr	975	14	investigated	investigate	VBN
cord-006860-a3b8hyyr	975	15	stimuli	stimulus	NNS
cord-006860-a3b8hyyr	975	16	by	by	IN
cord-006860-a3b8hyyr	975	17	HC	HC	NNP
cord-006860-a3b8hyyr	975	18	in	in	IN
cord-006860-a3b8hyyr	975	19	concentrations	concentration	NNS
cord-006860-a3b8hyyr	975	20	reached	reach	VBN
cord-006860-a3b8hyyr	975	21	under	under	IN
cord-006860-a3b8hyyr	975	22	pathophysiological	pathophysiological	JJ
cord-006860-a3b8hyyr	975	23	condititions	conditition	NNS
cord-006860-a3b8hyyr	975	24	.	.	.
cord-006860-a3b8hyyr	976	1	The	the	DT
cord-006860-a3b8hyyr	976	2	effect	effect	NN
cord-006860-a3b8hyyr	976	3	of	of	IN
cord-006860-a3b8hyyr	976	4	pysical	pysical	JJ
cord-006860-a3b8hyyr	976	5	exercise	exercise	NN
cord-006860-a3b8hyyr	976	6	on	on	IN
cord-006860-a3b8hyyr	976	7	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	976	8	parameters	parameter	NNS
cord-006860-a3b8hyyr	976	9	was	be	VBD
cord-006860-a3b8hyyr	976	10	studied	study	VBN
cord-006860-a3b8hyyr	976	11	in	in	IN
cord-006860-a3b8hyyr	976	12	12	12	CD
cord-006860-a3b8hyyr	976	13	patients	patient	NNS
cord-006860-a3b8hyyr	976	14	(	(	-LRB-
cord-006860-a3b8hyyr	976	15	male	male	JJ
cord-006860-a3b8hyyr	976	16	,	,	,
cord-006860-a3b8hyyr	976	17	mean	mean	VB
cord-006860-a3b8hyyr	976	18	age	age	NN
cord-006860-a3b8hyyr	976	19	:	:	:
cord-006860-a3b8hyyr	976	20	55	55	CD
cord-006860-a3b8hyyr	976	21	[	[	-LRB-
cord-006860-a3b8hyyr	976	22	range	range	NN
cord-006860-a3b8hyyr	976	23	36	36	CD
cord-006860-a3b8hyyr	976	24	-	-	SYM
cord-006860-a3b8hyyr	976	25	68	68	CD
cord-006860-a3b8hyyr	976	26	]	]	-RRB-
cord-006860-a3b8hyyr	976	27	yrs	yr	NNS
cord-006860-a3b8hyyr	976	28	)	)	-RRB-
cord-006860-a3b8hyyr	976	29	with	with	IN
cord-006860-a3b8hyyr	976	30	angiographically	angiographically	RB
cord-006860-a3b8hyyr	976	31	documented	document	VBN
cord-006860-a3b8hyyr	976	32	coronary	coronary	JJ
cord-006860-a3b8hyyr	976	33	artery	artery	NN
cord-006860-a3b8hyyr	976	34	disease	disease	NN
cord-006860-a3b8hyyr	976	35	(	(	-LRB-
cord-006860-a3b8hyyr	976	36	CAD	CAD	NNP
cord-006860-a3b8hyyr	976	37	)	)	-RRB-
cord-006860-a3b8hyyr	976	38	and	and	CC
cord-006860-a3b8hyyr	976	39	in	in	IN
cord-006860-a3b8hyyr	976	40	11	11	CD
cord-006860-a3b8hyyr	976	41	controls	control	NNS
cord-006860-a3b8hyyr	976	42	(	(	-LRB-
cord-006860-a3b8hyyr	976	43	male	male	NN
cord-006860-a3b8hyyr	976	44	,	,	,
cord-006860-a3b8hyyr	976	45	53	53	CD
cord-006860-a3b8hyyr	976	46	[	[	-LRB-
cord-006860-a3b8hyyr	976	47	43	43	CD
cord-006860-a3b8hyyr	976	48	-	-	SYM
cord-006860-a3b8hyyr	976	49	62	62	CD
cord-006860-a3b8hyyr	976	50	]	]	-RRB-
cord-006860-a3b8hyyr	976	51	yrs	yrs	NN
cord-006860-a3b8hyyr	976	52	)	)	-RRB-
cord-006860-a3b8hyyr	977	1	both	both	DT
cord-006860-a3b8hyyr	977	2	participating	participate	VBG
cord-006860-a3b8hyyr	977	3	in	in	IN
cord-006860-a3b8hyyr	977	4	an	an	DT
cord-006860-a3b8hyyr	977	5	1	1	CD
cord-006860-a3b8hyyr	977	6	hour	hour	NN
cord-006860-a3b8hyyr	977	7	group	group	NN
cord-006860-a3b8hyyr	977	8	exercise	exercise	NN
cord-006860-a3b8hyyr	977	9	session	session	NN
cord-006860-a3b8hyyr	977	10	for	for	IN
cord-006860-a3b8hyyr	977	11	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	977	12	rehabilitation	rehabilitation	NN
cord-006860-a3b8hyyr	977	13	.	.	.
cord-006860-a3b8hyyr	978	1	In	in	IN
cord-006860-a3b8hyyr	978	2	each	each	DT
cord-006860-a3b8hyyr	978	3	group	group	NN
cord-006860-a3b8hyyr	978	4	relevant	relevant	JJ
cord-006860-a3b8hyyr	978	5	arteriosclerotic	arteriosclerotic	JJ
cord-006860-a3b8hyyr	978	6	lesions	lesion	NNS
cord-006860-a3b8hyyr	978	7	in	in	IN
cord-006860-a3b8hyyr	978	8	carotid	carotid	NN
cord-006860-a3b8hyyr	978	9	,	,	,
cord-006860-a3b8hyyr	978	10	abdominal	abdominal	JJ
cord-006860-a3b8hyyr	978	11	and	and	CC
cord-006860-a3b8hyyr	978	12	leg	leg	NN
cord-006860-a3b8hyyr	978	13	arteries	artery	NNS
cord-006860-a3b8hyyr	978	14	were	be	VBD
cord-006860-a3b8hyyr	978	15	excluded	exclude	VBN
cord-006860-a3b8hyyr	978	16	by	by	IN
cord-006860-a3b8hyyr	978	17	Doppler	Doppler	NNP
cord-006860-a3b8hyyr	978	18	ultrasound	ultrasound	NN
cord-006860-a3b8hyyr	978	19	examinations	examination	NNS
cord-006860-a3b8hyyr	978	20	.	.	.
cord-006860-a3b8hyyr	979	1	Patients	patient	NNS
cord-006860-a3b8hyyr	979	2	were	be	VBD
cord-006860-a3b8hyyr	979	3	all	all	RB
cord-006860-a3b8hyyr	979	4	under	under	IN
cord-006860-a3b8hyyr	979	5	6-blocking	6-blocking	CD
cord-006860-a3b8hyyr	979	6	agents	agent	NNS
cord-006860-a3b8hyyr	979	7	and	and	CC
cord-006860-a3b8hyyr	979	8	aspirin	aspirin	NN
cord-006860-a3b8hyyr	979	9	.	.	.
cord-006860-a3b8hyyr	980	1	Plasma	plasma	NN
cord-006860-a3b8hyyr	980	2	levels	level	NNS
cord-006860-a3b8hyyr	980	3	of	of	IN
cord-006860-a3b8hyyr	980	4	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	980	5	fragment	fragment	NN
cord-006860-a3b8hyyr	980	6	1	1	CD
cord-006860-a3b8hyyr	980	7	+	+	SYM
cord-006860-a3b8hyyr	980	8	2	2	CD
cord-006860-a3b8hyyr	981	1	(	(	-LRB-
cord-006860-a3b8hyyr	981	2	PTFI+2	PTFI+2	NNP
cord-006860-a3b8hyyr	981	3	)	)	-RRB-
cord-006860-a3b8hyyr	982	1	and	and	CC
cord-006860-a3b8hyyr	982	2	fibrinopeptide	fibrinopeptide	VBD
cord-006860-a3b8hyyr	982	3	A	a	DT
cord-006860-a3b8hyyr	982	4	(	(	-LRB-
cord-006860-a3b8hyyr	982	5	FPA	fpa	NN
cord-006860-a3b8hyyr	982	6	)	)	-RRB-
cord-006860-a3b8hyyr	983	1	reflecting	reflect	VBG
cord-006860-a3b8hyyr	983	2	formation	formation	NN
cord-006860-a3b8hyyr	983	3	of	of	IN
cord-006860-a3b8hyyr	983	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	983	5	and	and	CC
cord-006860-a3b8hyyr	983	6	fibrin	fibrin	NN
cord-006860-a3b8hyyr	983	7	,	,	,
cord-006860-a3b8hyyr	983	8	respectively	respectively	RB
cord-006860-a3b8hyyr	983	9	,	,	,
cord-006860-a3b8hyyr	983	10	were	be	VBD
cord-006860-a3b8hyyr	983	11	measured	measure	VBN
cord-006860-a3b8hyyr	983	12	at	at	IN
cord-006860-a3b8hyyr	983	13	rest	rest	NN
cord-006860-a3b8hyyr	983	14	and	and	CC
cord-006860-a3b8hyyr	983	15	immediately	immediately	RB
cord-006860-a3b8hyyr	983	16	after	after	IN
cord-006860-a3b8hyyr	983	17	1	1	CD
cord-006860-a3b8hyyr	983	18	hour	hour	NN
cord-006860-a3b8hyyr	983	19	of	of	IN
cord-006860-a3b8hyyr	983	20	exercise	exercise	NN
cord-006860-a3b8hyyr	983	21	consisting	consisting	NN
cord-006860-a3b8hyyr	983	22	of	of	IN
cord-006860-a3b8hyyr	983	23	jogging	jogging	NN
cord-006860-a3b8hyyr	983	24	,	,	,
cord-006860-a3b8hyyr	983	25	light	light	JJ
cord-006860-a3b8hyyr	983	26	gymnastics	gymnastic	NNS
cord-006860-a3b8hyyr	983	27	and	and	CC
cord-006860-a3b8hyyr	983	28	ball	ball	NN
cord-006860-a3b8hyyr	983	29	games	game	NNS
cord-006860-a3b8hyyr	983	30	.	.	.
cord-006860-a3b8hyyr	984	1	Training	training	NN
cord-006860-a3b8hyyr	984	2	intensity	intensity	NN
cord-006860-a3b8hyyr	984	3	in	in	IN
cord-006860-a3b8hyyr	984	4	both	both	DT
cord-006860-a3b8hyyr	984	5	groups	group	NNS
cord-006860-a3b8hyyr	984	6	was	be	VBD
cord-006860-a3b8hyyr	984	7	comparable	comparable	JJ
cord-006860-a3b8hyyr	984	8	as	as	IN
cord-006860-a3b8hyyr	984	9	indicated	indicate	VBN
cord-006860-a3b8hyyr	984	10	by	by	IN
cord-006860-a3b8hyyr	984	11	the	the	DT
cord-006860-a3b8hyyr	984	12	mean	mean	JJ
cord-006860-a3b8hyyr	984	13	heart	heart	NN
cord-006860-a3b8hyyr	984	14	rate	rate	NN
cord-006860-a3b8hyyr	984	15	during	during	IN
cord-006860-a3b8hyyr	984	16	exercise	exercise	NN
cord-006860-a3b8hyyr	984	17	corresponding	correspond	VBG
cord-006860-a3b8hyyr	984	18	in	in	IN
cord-006860-a3b8hyyr	984	19	patients	patient	NNS
cord-006860-a3b8hyyr	984	20	to	to	IN
cord-006860-a3b8hyyr	984	21	80	80	CD
cord-006860-a3b8hyyr	984	22	+	+	SYM
cord-006860-a3b8hyyr	984	23	6	6	CD
cord-006860-a3b8hyyr	984	24	%	%	NN
cord-006860-a3b8hyyr	984	25	(	(	-LRB-
cord-006860-a3b8hyyr	984	26	mean-+SD	mean-+SD	NNP
cord-006860-a3b8hyyr	984	27	)	)	-RRB-
cord-006860-a3b8hyyr	984	28	and	and	CC
cord-006860-a3b8hyyr	984	29	in	in	IN
cord-006860-a3b8hyyr	984	30	controls	control	NNS
cord-006860-a3b8hyyr	984	31	to	to	IN
cord-006860-a3b8hyyr	984	32	79-+5	79-+5	CD
cord-006860-a3b8hyyr	984	33	%	%	NN
cord-006860-a3b8hyyr	984	34	of	of	IN
cord-006860-a3b8hyyr	984	35	the	the	DT
cord-006860-a3b8hyyr	984	36	maximal	maximal	JJ
cord-006860-a3b8hyyr	984	37	heart	heart	NN
cord-006860-a3b8hyyr	984	38	rate	rate	NN
cord-006860-a3b8hyyr	984	39	previously	previously	RB
cord-006860-a3b8hyyr	984	40	determined	determine	VBN
cord-006860-a3b8hyyr	984	41	on	on	IN
cord-006860-a3b8hyyr	984	42	a	a	DT
cord-006860-a3b8hyyr	984	43	bicycle	bicycle	NN
cord-006860-a3b8hyyr	984	44	ergometer	ergometer	NN
cord-006860-a3b8hyyr	984	45	.	.	.
cord-006860-a3b8hyyr	985	1	Baseline	baseline	JJ
cord-006860-a3b8hyyr	985	2	values	value	NNS
cord-006860-a3b8hyyr	985	3	for	for	IN
cord-006860-a3b8hyyr	985	4	PTF1	PTF1	NNP
cord-006860-a3b8hyyr	985	5	+2	+2	,
cord-006860-a3b8hyyr	985	6	were	be	VBD
cord-006860-a3b8hyyr	985	7	significantly	significantly	RB
cord-006860-a3b8hyyr	985	8	lower	low	JJR
cord-006860-a3b8hyyr	985	9	in	in	IN
cord-006860-a3b8hyyr	985	10	oatients	oatient	NNS
cord-006860-a3b8hyyr	985	11	(	(	-LRB-
cord-006860-a3b8hyyr	985	12	0.67-+0.15	0.67-+0.15	CD
cord-006860-a3b8hyyr	985	13	nmol	nmol	NNP
cord-006860-a3b8hyyr	985	14	/	/	,
cord-006860-a3b8hyyr	985	15	I	-PRON-	PRP
cord-006860-a3b8hyyr	985	16	;	;	:
cord-006860-a3b8hyyr	986	1	mean-+SD	mean-+sd	LS
cord-006860-a3b8hyyr	986	2	)	)	-RRB-
cord-006860-a3b8hyyr	986	3	than	than	IN
cord-006860-a3b8hyyr	986	4	in	in	IN
cord-006860-a3b8hyyr	986	5	controls	control	NNS
cord-006860-a3b8hyyr	986	6	(	(	-LRB-
cord-006860-a3b8hyyr	986	7	1.01-+0.21	1.01-+0.21	CD
cord-006860-a3b8hyyr	986	8	;	;	:
cord-006860-a3b8hyyr	987	1	P<0.001	P<0.001	NNP
cord-006860-a3b8hyyr	987	2	i.	i.	NNP
cord-006860-a3b8hyyr	988	1	After	after	IN
cord-006860-a3b8hyyr	988	2	exercise	exercise	NN
cord-006860-a3b8hyyr	988	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	988	4	found	find	VBD
cord-006860-a3b8hyyr	988	5	an	an	DT
cord-006860-a3b8hyyr	988	6	increase	increase	NN
cord-006860-a3b8hyyr	988	7	of	of	IN
cord-006860-a3b8hyyr	988	8	PTF1	PTF1	NNP
cord-006860-a3b8hyyr	988	9	+2	+2	NN
cord-006860-a3b8hyyr	988	10	in	in	IN
cord-006860-a3b8hyyr	988	11	controls	control	NNS
cord-006860-a3b8hyyr	988	12	to	to	IN
cord-006860-a3b8hyyr	988	13	1.14-+0.24	1.14-+0.24	CD
cord-006860-a3b8hyyr	988	14	nmol	nmol	NNP
cord-006860-a3b8hyyr	988	15	/	/	SYM
cord-006860-a3b8hyyr	988	16	I	-PRON-	PRP
cord-006860-a3b8hyyr	988	17	(	(	-LRB-
cord-006860-a3b8hyyr	988	18	P<0.001	P<0.001	NNP
cord-006860-a3b8hyyr	988	19	)	)	-RRB-
cord-006860-a3b8hyyr	989	1	while	while	IN
cord-006860-a3b8hyyr	989	2	in	in	IN
cord-006860-a3b8hyyr	989	3	patients	patient	NNS
cord-006860-a3b8hyyr	989	4	PTFI+2	PTFI+2	NNP
cord-006860-a3b8hyyr	989	5	remained	remain	VBD
cord-006860-a3b8hyyr	989	6	unchanged	unchanged	JJ
cord-006860-a3b8hyyr	989	7	(	(	-LRB-
cord-006860-a3b8hyyr	990	1	0.67-+	0.67-+	CD
cord-006860-a3b8hyyr	990	2	0.14	0.14	CD
cord-006860-a3b8hyyr	990	3	after	after	RB
cord-006860-a3b8hyyr	990	4	)	)	-RRB-
cord-006860-a3b8hyyr	990	5	.	.	.
cord-006860-a3b8hyyr	991	1	Accordingly	accordingly	RB
cord-006860-a3b8hyyr	991	2	,	,	,
cord-006860-a3b8hyyr	991	3	exercise	exercise	NN
cord-006860-a3b8hyyr	991	4	induced	induce	VBN
cord-006860-a3b8hyyr	991	5	r	r	NN
cord-006860-a3b8hyyr	991	6	se	se	FW
cord-006860-a3b8hyyr	991	7	of	of	IN
cord-006860-a3b8hyyr	991	8	FPA	FPA	NNP
cord-006860-a3b8hyyr	991	9	was	be	VBD
cord-006860-a3b8hyyr	992	1	more	more	RBR
cord-006860-a3b8hyyr	992	2	pronounced	pronounce	VBN
cord-006860-a3b8hyyr	992	3	in	in	IN
cord-006860-a3b8hyyr	992	4	controls	control	NNS
cord-006860-a3b8hyyr	992	5	(	(	-LRB-
cord-006860-a3b8hyyr	992	6	from	from	IN
cord-006860-a3b8hyyr	992	7	0.62-+0.24	0.62-+0.24	CD
cord-006860-a3b8hyyr	992	8	to	to	IN
cord-006860-a3b8hyyr	992	9	1.60-+0.62ng	1.60-+0.62ng	NNP
cord-006860-a3b8hyyr	992	10	/	/	SYM
cord-006860-a3b8hyyr	992	11	mt	mt	NNP
cord-006860-a3b8hyyr	992	12	;	;	:
cord-006860-a3b8hyyr	992	13	P<0.001	P<0.001	NNP
cord-006860-a3b8hyyr	992	14	)	)	-RRB-
cord-006860-a3b8hyyr	992	15	than	than	IN
cord-006860-a3b8hyyr	992	16	in	in	IN
cord-006860-a3b8hyyr	992	17	patients	patient	NNS
cord-006860-a3b8hyyr	992	18	(	(	-LRB-
cord-006860-a3b8hyyr	992	19	from	from	IN
cord-006860-a3b8hyyr	992	20	0.63-+0.26	0.63-+0.26	CD
cord-006860-a3b8hyyr	992	21	to	to	IN
cord-006860-a3b8hyyr	992	22	1.20	1.20	CD
cord-006860-a3b8hyyr	992	23	+	+	CD
cord-006860-a3b8hyyr	992	24	0.46ng	0.46ng	CD
cord-006860-a3b8hyyr	992	25	/	/	SYM
cord-006860-a3b8hyyr	992	26	ml	ml	NN
cord-006860-a3b8hyyr	992	27	;	;	:
cord-006860-a3b8hyyr	992	28	P<0.00	p<0.00	JJ
cord-006860-a3b8hyyr	992	29	t	t	NN
cord-006860-a3b8hyyr	992	30	)	)	-RRB-
cord-006860-a3b8hyyr	992	31	.	.	.
cord-006860-a3b8hyyr	993	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	993	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	993	3	that	that	IN
cord-006860-a3b8hyyr	993	4	in	in	IN
cord-006860-a3b8hyyr	993	5	terms	term	NNS
cord-006860-a3b8hyyr	993	6	of	of	IN
cord-006860-a3b8hyyr	993	7	thrombin	thrombin	NN
cord-006860-a3b8hyyr	993	8	and	and	CC
cord-006860-a3b8hyyr	993	9	fibrin	fibrin	NN
cord-006860-a3b8hyyr	993	10	generation	generation	NN
cord-006860-a3b8hyyr	993	11	exercise	exercise	NN
cord-006860-a3b8hyyr	993	12	training	training	NN
cord-006860-a3b8hyyr	993	13	does	do	VBZ
cord-006860-a3b8hyyr	993	14	not	not	RB
cord-006860-a3b8hyyr	993	15	exert	exert	VB
cord-006860-a3b8hyyr	993	16	detrimental	detrimental	JJ
cord-006860-a3b8hyyr	993	17	effects	effect	NNS
cord-006860-a3b8hyyr	993	18	on	on	IN
cord-006860-a3b8hyyr	993	19	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	993	20	in	in	IN
cord-006860-a3b8hyyr	993	21	patients	patient	NNS
cord-006860-a3b8hyyr	993	22	with	with	IN
cord-006860-a3b8hyyr	993	23	CAD	CAD	NNP
cord-006860-a3b8hyyr	993	24	.	.	.
cord-006860-a3b8hyyr	994	1	Lower	lower	VB
cord-006860-a3b8hyyr	994	2	baseline	baseline	JJ
cord-006860-a3b8hyyr	994	3	values	value	NNS
cord-006860-a3b8hyyr	994	4	and	and	CC
cord-006860-a3b8hyyr	994	5	lack	lack	NN
cord-006860-a3b8hyyr	994	6	of	of	IN
cord-006860-a3b8hyyr	994	7	exercise	exercise	NN
cord-006860-a3b8hyyr	994	8	induced	induce	VBN
cord-006860-a3b8hyyr	994	9	increases	increase	NNS
cord-006860-a3b8hyyr	994	10	of	of	IN
cord-006860-a3b8hyyr	994	11	PTF1	PTF1	NNP
cord-006860-a3b8hyyr	994	12	+2	+2	CD
cord-006860-a3b8hyyr	994	13	in	in	IN
cord-006860-a3b8hyyr	994	14	patients	patient	NNS
cord-006860-a3b8hyyr	994	15	with	with	IN
cord-006860-a3b8hyyr	994	16	CAD	CAD	NNP
cord-006860-a3b8hyyr	994	17	might	may	MD
cord-006860-a3b8hyyr	994	18	be	be	VB
cord-006860-a3b8hyyr	994	19	attributed	attribute	VBN
cord-006860-a3b8hyyr	994	20	to	to	IN
cord-006860-a3b8hyyr	994	21	medication	medication	NN
cord-006860-a3b8hyyr	994	22	with	with	IN
cord-006860-a3b8hyyr	994	23	aspirin	aspirin	NN
cord-006860-a3b8hyyr	994	24	and/or	and/or	CC
cord-006860-a3b8hyyr	994	25	B	b	NN
cord-006860-a3b8hyyr	994	26	-	-	HYPH
cord-006860-a3b8hyyr	994	27	blocking	block	VBG
cord-006860-a3b8hyyr	994	28	agents	agent	NNS
cord-006860-a3b8hyyr	994	29	.	.	.
cord-006860-a3b8hyyr	995	1	Periodontitis	Periodontitis	NNP
cord-006860-a3b8hyyr	995	2	marginalis	marginalis	NNP
cord-006860-a3b8hyyr	995	3	(	(	-LRB-
cord-006860-a3b8hyyr	995	4	Pm	pm	NN
cord-006860-a3b8hyyr	995	5	)	)	-RRB-
cord-006860-a3b8hyyr	995	6	is	be	VBZ
cord-006860-a3b8hyyr	995	7	an	an	DT
cord-006860-a3b8hyyr	995	8	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	995	9	oral	oral	JJ
cord-006860-a3b8hyyr	995	10	disease	disease	NN
cord-006860-a3b8hyyr	995	11	that	that	WDT
cord-006860-a3b8hyyr	995	12	is	be	VBZ
cord-006860-a3b8hyyr	995	13	caused	cause	VBN
cord-006860-a3b8hyyr	995	14	by	by	IN
cord-006860-a3b8hyyr	995	15	gram	gram	NN
cord-006860-a3b8hyyr	995	16	-	-	HYPH
cord-006860-a3b8hyyr	995	17	negative	negative	JJ
cord-006860-a3b8hyyr	995	18	bacteria	bacteria	NNS
cord-006860-a3b8hyyr	995	19	and	and	CC
cord-006860-a3b8hyyr	995	20	that	that	DT
cord-006860-a3b8hyyr	995	21	has	have	VBZ
cord-006860-a3b8hyyr	995	22	a	a	DT
cord-006860-a3b8hyyr	995	23	high	high	JJ
cord-006860-a3b8hyyr	995	24	incidence	incidence	NN
cord-006860-a3b8hyyr	995	25	in	in	IN
cord-006860-a3b8hyyr	995	26	the	the	DT
cord-006860-a3b8hyyr	995	27	second	second	JJ
cord-006860-a3b8hyyr	995	28	half	half	NN
cord-006860-a3b8hyyr	995	29	of	of	IN
cord-006860-a3b8hyyr	995	30	the	the	DT
cord-006860-a3b8hyyr	995	31	life	life	NN
cord-006860-a3b8hyyr	995	32	.	.	.
cord-006860-a3b8hyyr	996	1	Clinical	clinical	JJ
cord-006860-a3b8hyyr	996	2	signs	sign	NNS
cord-006860-a3b8hyyr	996	3	of	of	IN
cord-006860-a3b8hyyr	996	4	Pm	Pm	NNP
cord-006860-a3b8hyyr	996	5	are	be	VBP
cord-006860-a3b8hyyr	996	6	gingival	gingival	JJ
cord-006860-a3b8hyyr	996	7	bleeding	bleed	VBG
cord-006860-a3b8hyyr	996	8	,	,	,
cord-006860-a3b8hyyr	996	9	periodontal	periodontal	JJ
cord-006860-a3b8hyyr	996	10	pockets	pocket	NNS
cord-006860-a3b8hyyr	996	11	,	,	,
cord-006860-a3b8hyyr	996	12	alveolar	alveolar	JJ
cord-006860-a3b8hyyr	996	13	bone	bone	NN
cord-006860-a3b8hyyr	996	14	destruction	destruction	NN
cord-006860-a3b8hyyr	996	15	and	and	CC
cord-006860-a3b8hyyr	996	16	loss	loss	NN
cord-006860-a3b8hyyr	996	17	of	of	IN
cord-006860-a3b8hyyr	996	18	teeth	tooth	NNS
cord-006860-a3b8hyyr	996	19	.	.	.
cord-006860-a3b8hyyr	997	1	Recent	recent	JJ
cord-006860-a3b8hyyr	997	2	epidemiologlcal	epidemiologlcal	JJ
cord-006860-a3b8hyyr	997	3	studies	study	NNS
cord-006860-a3b8hyyr	997	4	have	have	VBP
cord-006860-a3b8hyyr	997	5	provided	provide	VBN
cord-006860-a3b8hyyr	997	6	some	some	DT
cord-006860-a3b8hyyr	997	7	evidence	evidence	NN
cord-006860-a3b8hyyr	997	8	for	for	IN
cord-006860-a3b8hyyr	997	9	an	an	DT
cord-006860-a3b8hyyr	997	10	association	association	NN
cord-006860-a3b8hyyr	997	11	between	between	IN
cord-006860-a3b8hyyr	997	12	Pm	Pm	NNP
cord-006860-a3b8hyyr	997	13	and	and	CC
cord-006860-a3b8hyyr	997	14	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	997	15	.	.	.
cord-006860-a3b8hyyr	998	1	In	in	IN
cord-006860-a3b8hyyr	998	2	the	the	DT
cord-006860-a3b8hyyr	998	3	present	present	JJ
cord-006860-a3b8hyyr	998	4	paper	paper	NN
cord-006860-a3b8hyyr	998	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	998	6	will	will	MD
cord-006860-a3b8hyyr	998	7	summarise	summarise	VB
cord-006860-a3b8hyyr	998	8	some	some	DT
cord-006860-a3b8hyyr	998	9	of	of	IN
cord-006860-a3b8hyyr	998	10	the	the	DT
cord-006860-a3b8hyyr	998	11	results	result	NNS
cord-006860-a3b8hyyr	998	12	that	that	WDT
cord-006860-a3b8hyyr	998	13	we	-PRON-	PRP
cord-006860-a3b8hyyr	998	14	have	have	VBP
cord-006860-a3b8hyyr	998	15	obtained	obtain	VBN
cord-006860-a3b8hyyr	998	16	in	in	IN
cord-006860-a3b8hyyr	998	17	studies	study	NNS
cord-006860-a3b8hyyr	998	18	on	on	IN
cord-006860-a3b8hyyr	998	19	patients	patient	NNS
cord-006860-a3b8hyyr	998	20	with	with	IN
cord-006860-a3b8hyyr	998	21	Pm	Pm	NNP
cord-006860-a3b8hyyr	998	22	as	as	RB
cord-006860-a3b8hyyr	998	23	well	well	RB
cord-006860-a3b8hyyr	998	24	as	as	IN
cord-006860-a3b8hyyr	998	25	on	on	IN
cord-006860-a3b8hyyr	998	26	patients	patient	NNS
cord-006860-a3b8hyyr	998	27	with	with	IN
cord-006860-a3b8hyyr	998	28	hypercholesterolaemia	hypercholesterolaemia	NN
cord-006860-a3b8hyyr	998	29	(	(	-LRB-
cord-006860-a3b8hyyr	998	30	HC	HC	NNP
cord-006860-a3b8hyyr	998	31	)	)	-RRB-
cord-006860-a3b8hyyr	998	32	and	and	CC
cord-006860-a3b8hyyr	998	33	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	998	34	.	.	.
cord-006860-a3b8hyyr	999	1	Pm	Pm	NNP
cord-006860-a3b8hyyr	999	2	was	be	VBD
cord-006860-a3b8hyyr	999	3	frequently	frequently	RB
cord-006860-a3b8hyyr	999	4	found	find	VBN
cord-006860-a3b8hyyr	999	5	to	to	TO
cord-006860-a3b8hyyr	999	6	be	be	VB
cord-006860-a3b8hyyr	999	7	associated	associate	VBN
cord-006860-a3b8hyyr	999	8	with	with	IN
cord-006860-a3b8hyyr	999	9	HC	HC	NNP
cord-006860-a3b8hyyr	999	10	(	(	-LRB-
cord-006860-a3b8hyyr	999	11	90	90	CD
cord-006860-a3b8hyyr	999	12	%	%	NN
cord-006860-a3b8hyyr	999	13	in	in	IN
cord-006860-a3b8hyyr	999	14	rapidly	rapidly	RB
cord-006860-a3b8hyyr	999	15	progressive	progressive	JJ
cord-006860-a3b8hyyr	999	16	Pm	Pm	NNP
cord-006860-a3b8hyyr	999	17	)	)	-RRB-
cord-006860-a3b8hyyr	999	18	and	and	CC
cord-006860-a3b8hyyr	999	19	increased	increase	VBN
cord-006860-a3b8hyyr	999	20	reactivity	reactivity	NN
cord-006860-a3b8hyyr	999	21	of	of	IN
cord-006860-a3b8hyyr	999	22	peripheral	peripheral	JJ
cord-006860-a3b8hyyr	999	23	blood	blood	NN
cord-006860-a3b8hyyr	999	24	neutrophils	neutrophil	NNS
cord-006860-a3b8hyyr	999	25	and	and	CC
cord-006860-a3b8hyyr	999	26	platelets	platelet	NNS
cord-006860-a3b8hyyr	999	27	(	(	-LRB-
cord-006860-a3b8hyyr	999	28	e.g.	e.g.	JJ
cord-006860-a3b8hyyr	999	29	generation	generation	NN
cord-006860-a3b8hyyr	999	30	of	of	IN
cord-006860-a3b8hyyr	999	31	oxygen	oxygen	NN
cord-006860-a3b8hyyr	999	32	radicals	radical	NNS
cord-006860-a3b8hyyr	999	33	and	and	CC
cord-006860-a3b8hyyr	999	34	PAF	PAF	NNP
cord-006860-a3b8hyyr	999	35	-	-	HYPH
cord-006860-a3b8hyyr	999	36	induced	induce	VBN
cord-006860-a3b8hyyr	999	37	aggregation	aggregation	NN
cord-006860-a3b8hyyr	999	38	)	)	-RRB-
cord-006860-a3b8hyyr	999	39	.	.	.
cord-006860-a3b8hyyr	1000	1	Patients	patient	NNS
cord-006860-a3b8hyyr	1000	2	with	with	IN
cord-006860-a3b8hyyr	1000	3	HC	HC	NNP
cord-006860-a3b8hyyr	1000	4	and	and	CC
cord-006860-a3b8hyyr	1000	5	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	1000	6	had	have	VBD
cord-006860-a3b8hyyr	1000	7	a	a	DT
cord-006860-a3b8hyyr	1000	8	higher	high	JJR
cord-006860-a3b8hyyr	1000	9	frequency	frequency	NN
cord-006860-a3b8hyyr	1000	10	of	of	IN
cord-006860-a3b8hyyr	1000	11	severe	severe	JJ
cord-006860-a3b8hyyr	1000	12	Pm	pm	NN
cord-006860-a3b8hyyr	1000	13	when	when	WRB
cord-006860-a3b8hyyr	1000	14	compared	compare	VBN
cord-006860-a3b8hyyr	1000	15	with	with	IN
cord-006860-a3b8hyyr	1000	16	data	datum	NNS
cord-006860-a3b8hyyr	1000	17	on	on	IN
cord-006860-a3b8hyyr	1000	18	the	the	DT
cord-006860-a3b8hyyr	1000	19	community	community	NN
cord-006860-a3b8hyyr	1000	20	periodontal	periodontal	JJ
cord-006860-a3b8hyyr	1000	21	health	health	NN
cord-006860-a3b8hyyr	1000	22	.	.	.
cord-006860-a3b8hyyr	1001	1	The	the	DT
cord-006860-a3b8hyyr	1001	2	severity	severity	NN
cord-006860-a3b8hyyr	1001	3	of	of	IN
cord-006860-a3b8hyyr	1001	4	Pm	Pm	NNP
cord-006860-a3b8hyyr	1001	5	was	be	VBD
cord-006860-a3b8hyyr	1001	6	higher	high	JJR
cord-006860-a3b8hyyr	1001	7	in	in	IN
cord-006860-a3b8hyyr	1001	8	patients	patient	NNS
cord-006860-a3b8hyyr	1001	9	with	with	IN
cord-006860-a3b8hyyr	1001	10	plasma	plasma	NN
cord-006860-a3b8hyyr	1001	11	cholesterol	cholesterol	NN
cord-006860-a3b8hyyr	1001	12	levels	level	NNS
cord-006860-a3b8hyyr	1001	13	_	_	NNP
cord-006860-a3b8hyyr	1002	1	>	>	XX
cord-006860-a3b8hyyr	1003	1	6.5	6.5	CD
cord-006860-a3b8hyyr	1003	2	mM	mm	NN
cord-006860-a3b8hyyr	1003	3	when	when	WRB
cord-006860-a3b8hyyr	1003	4	compared	compare	VBN
cord-006860-a3b8hyyr	1003	5	to	to	IN
cord-006860-a3b8hyyr	1003	6	those	those	DT
cord-006860-a3b8hyyr	1003	7	with	with	IN
cord-006860-a3b8hyyr	1003	8	plasma	plasma	NN
cord-006860-a3b8hyyr	1003	9	cholesterol	cholesterol	NN
cord-006860-a3b8hyyr	1003	10	<	<	XX
cord-006860-a3b8hyyr	1003	11	6.5	6.5	CD
cord-006860-a3b8hyyr	1003	12	mM.	mm.	NN
cord-006860-a3b8hyyr	1004	1	In	in	IN
cord-006860-a3b8hyyr	1004	2	patients	patient	NNS
cord-006860-a3b8hyyr	1004	3	with	with	IN
cord-006860-a3b8hyyr	1004	4	coronary	coronary	JJ
cord-006860-a3b8hyyr	1004	5	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	1004	6	the	the	DT
cord-006860-a3b8hyyr	1004	7	severity	severity	NN
cord-006860-a3b8hyyr	1004	8	of	of	IN
cord-006860-a3b8hyyr	1004	9	Pm	Pm	NNP
cord-006860-a3b8hyyr	1004	10	was	be	VBD
cord-006860-a3b8hyyr	1004	11	significantly	significantly	RB
cord-006860-a3b8hyyr	1004	12	correlated	correlate	VBN
cord-006860-a3b8hyyr	1004	13	with	with	IN
cord-006860-a3b8hyyr	1004	14	plasma	plasma	NN
cord-006860-a3b8hyyr	1004	15	cholesterol	cholesterol	NN
cord-006860-a3b8hyyr	1004	16	level	level	NN
cord-006860-a3b8hyyr	1004	17	,	,	,
cord-006860-a3b8hyyr	1004	18	systolic	systolic	JJ
cord-006860-a3b8hyyr	1004	19	blood	blood	NN
cord-006860-a3b8hyyr	1004	20	pressure	pressure	NN
cord-006860-a3b8hyyr	1004	21	and	and	CC
cord-006860-a3b8hyyr	1004	22	the	the	DT
cord-006860-a3b8hyyr	1004	23	number	number	NN
cord-006860-a3b8hyyr	1004	24	of	of	IN
cord-006860-a3b8hyyr	1004	25	diseased	diseased	JJ
cord-006860-a3b8hyyr	1004	26	coronary	coronary	JJ
cord-006860-a3b8hyyr	1004	27	arteries	artery	NNS
cord-006860-a3b8hyyr	1004	28	.	.	.
cord-006860-a3b8hyyr	1005	1	These	these	DT
cord-006860-a3b8hyyr	1005	2	results	result	NNS
cord-006860-a3b8hyyr	1005	3	provide	provide	VBP
cord-006860-a3b8hyyr	1005	4	further	further	JJ
cord-006860-a3b8hyyr	1005	5	evidence	evidence	NN
cord-006860-a3b8hyyr	1005	6	for	for	IN
cord-006860-a3b8hyyr	1005	7	an	an	DT
cord-006860-a3b8hyyr	1005	8	association	association	NN
cord-006860-a3b8hyyr	1005	9	between	between	IN
cord-006860-a3b8hyyr	1005	10	Pm	Pm	NNP
cord-006860-a3b8hyyr	1005	11	,	,	,
cord-006860-a3b8hyyr	1005	12	HC	HC	NNP
cord-006860-a3b8hyyr	1005	13	and	and	CC
cord-006860-a3b8hyyr	1005	14	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	1005	15	.	.	.
cord-006860-a3b8hyyr	1006	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1006	2	can	can	MD
cord-006860-a3b8hyyr	1006	3	be	be	VB
cord-006860-a3b8hyyr	1006	4	speculated	speculate	VBN
cord-006860-a3b8hyyr	1006	5	that	that	IN
cord-006860-a3b8hyyr	1006	6	HC	HC	NNP
cord-006860-a3b8hyyr	1006	7	is	be	VBZ
cord-006860-a3b8hyyr	1006	8	not	not	RB
cord-006860-a3b8hyyr	1006	9	only	only	RB
cord-006860-a3b8hyyr	1006	10	a	a	DT
cord-006860-a3b8hyyr	1006	11	risk	risk	NN
cord-006860-a3b8hyyr	1006	12	factor	factor	NN
cord-006860-a3b8hyyr	1006	13	for	for	IN
cord-006860-a3b8hyyr	1006	14	atheroscterosis	atheroscterosis	NN
cord-006860-a3b8hyyr	1006	15	but	but	CC
cord-006860-a3b8hyyr	1006	16	also	also	RB
cord-006860-a3b8hyyr	1006	17	a	a	DT
cord-006860-a3b8hyyr	1006	18	risk	risk	NN
cord-006860-a3b8hyyr	1006	19	factor	factor	NN
cord-006860-a3b8hyyr	1006	20	for	for	IN
cord-006860-a3b8hyyr	1006	21	Pm	pm	NN
cord-006860-a3b8hyyr	1006	22	and	and	CC
cord-006860-a3b8hyyr	1006	23	acts	act	NNS
cord-006860-a3b8hyyr	1006	24	by	by	IN
cord-006860-a3b8hyyr	1006	25	increasing	increase	VBG
cord-006860-a3b8hyyr	1006	26	the	the	DT
cord-006860-a3b8hyyr	1006	27	reactivity	reactivity	NN
cord-006860-a3b8hyyr	1006	28	of	of	IN
cord-006860-a3b8hyyr	1006	29	neutrophils	neutrophil	NNS
cord-006860-a3b8hyyr	1006	30	and	and	CC
cord-006860-a3b8hyyr	1006	31	platelets	platelet	NNS
cord-006860-a3b8hyyr	1006	32	.	.	.
cord-006860-a3b8hyyr	1007	1	On	on	IN
cord-006860-a3b8hyyr	1007	2	the	the	DT
cord-006860-a3b8hyyr	1007	3	other	other	JJ
cord-006860-a3b8hyyr	1007	4	hand	hand	NN
cord-006860-a3b8hyyr	1007	5	,	,	,
cord-006860-a3b8hyyr	1007	6	Pm	Pm	NNP
cord-006860-a3b8hyyr	1007	7	as	as	IN
cord-006860-a3b8hyyr	1007	8	a	a	DT
cord-006860-a3b8hyyr	1007	9	mild	mild	JJ
cord-006860-a3b8hyyr	1007	10	chronic	chronic	JJ
cord-006860-a3b8hyyr	1007	11	inflammation	inflammation	NN
cord-006860-a3b8hyyr	1007	12	could	could	MD
cord-006860-a3b8hyyr	1007	13	promote	promote	VB
cord-006860-a3b8hyyr	1007	14	the	the	DT
cord-006860-a3b8hyyr	1007	15	development	development	NN
cord-006860-a3b8hyyr	1007	16	of	of	IN
cord-006860-a3b8hyyr	1007	17	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	1007	18	due	due	IN
cord-006860-a3b8hyyr	1007	19	to	to	IN
cord-006860-a3b8hyyr	1007	20	effects	effect	NNS
cord-006860-a3b8hyyr	1007	21	of	of	IN
cord-006860-a3b8hyyr	1007	22	endotoxins	endotoxin	NNS
cord-006860-a3b8hyyr	1007	23	on	on	IN
cord-006860-a3b8hyyr	1007	24	vessel	vessel	NN
cord-006860-a3b8hyyr	1007	25	wall	wall	NN
cord-006860-a3b8hyyr	1007	26	,	,	,
cord-006860-a3b8hyyr	1007	27	blood	blood	NN
cord-006860-a3b8hyyr	1007	28	cells	cell	NNS
cord-006860-a3b8hyyr	1007	29	and	and	CC
cord-006860-a3b8hyyr	1007	30	haemostatic	haemostatic	JJ
cord-006860-a3b8hyyr	1007	31	factors	factor	NNS
cord-006860-a3b8hyyr	1007	32	.	.	.
cord-006860-a3b8hyyr	1008	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1008	2	has	have	VBZ
cord-006860-a3b8hyyr	1008	3	been	be	VBN
cord-006860-a3b8hyyr	1008	4	also	also	RB
cord-006860-a3b8hyyr	1008	5	speculated	speculate	VBN
cord-006860-a3b8hyyr	1008	6	that	that	IN
cord-006860-a3b8hyyr	1008	7	phagocyting	phagocyte	VBG
cord-006860-a3b8hyyr	1008	8	leukocytes	leukocyte	NNS
cord-006860-a3b8hyyr	1008	9	in	in	IN
cord-006860-a3b8hyyr	1008	10	the	the	DT
cord-006860-a3b8hyyr	1008	11	inflamed	inflamed	JJ
cord-006860-a3b8hyyr	1008	12	periodontal	periodontal	JJ
cord-006860-a3b8hyyr	1008	13	tissues	tissue	NNS
cord-006860-a3b8hyyr	1008	14	could	could	MD
cord-006860-a3b8hyyr	1008	15	contribute	contribute	VB
cord-006860-a3b8hyyr	1008	16	to	to	IN
cord-006860-a3b8hyyr	1008	17	oxidative	oxidative	JJ
cord-006860-a3b8hyyr	1008	18	modification	modification	NN
cord-006860-a3b8hyyr	1008	19	of	of	IN
cord-006860-a3b8hyyr	1008	20	LDL	ldl	NN
cord-006860-a3b8hyyr	1008	21	.	.	.
cord-006860-a3b8hyyr	1009	1	So	so	RB
cord-006860-a3b8hyyr	1009	2	far	far	RB
cord-006860-a3b8hyyr	1009	3	,	,	,
cord-006860-a3b8hyyr	1009	4	there	there	EX
cord-006860-a3b8hyyr	1009	5	is	be	VBZ
cord-006860-a3b8hyyr	1009	6	no	no	DT
cord-006860-a3b8hyyr	1009	7	evidence	evidence	NN
cord-006860-a3b8hyyr	1009	8	that	that	IN
cord-006860-a3b8hyyr	1009	9	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	1009	10	may	may	MD
cord-006860-a3b8hyyr	1009	11	contribute	contribute	VB
cord-006860-a3b8hyyr	1009	12	to	to	IN
cord-006860-a3b8hyyr	1009	13	the	the	DT
cord-006860-a3b8hyyr	1009	14	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	1009	15	of	of	IN
cord-006860-a3b8hyyr	1009	16	Pro	Pro	NNP
cord-006860-a3b8hyyr	1009	17	Protein	Protein	NNP
cord-006860-a3b8hyyr	1009	18	Z	Z	NNP
cord-006860-a3b8hyyr	1009	19	(	(	-LRB-
cord-006860-a3b8hyyr	1009	20	PZ	PZ	NNP
cord-006860-a3b8hyyr	1009	21	)	)	-RRB-
cord-006860-a3b8hyyr	1009	22	is	be	VBZ
cord-006860-a3b8hyyr	1009	23	a	a	DT
cord-006860-a3b8hyyr	1009	24	vitamin	vitamin	NN
cord-006860-a3b8hyyr	1009	25	K	k	NN
cord-006860-a3b8hyyr	1009	26	dependant	dependant	JJ
cord-006860-a3b8hyyr	1009	27	plasma	plasma	NN
cord-006860-a3b8hyyr	1009	28	protein	protein	NN
cord-006860-a3b8hyyr	1009	29	synthesized	synthesize	VBN
cord-006860-a3b8hyyr	1009	30	in	in	IN
cord-006860-a3b8hyyr	1009	31	the	the	DT
cord-006860-a3b8hyyr	1009	32	liver	liver	NN
cord-006860-a3b8hyyr	1009	33	.	.	.
cord-006860-a3b8hyyr	1010	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1010	2	promotes	promote	VBZ
cord-006860-a3b8hyyr	1010	3	the	the	DT
cord-006860-a3b8hyyr	1010	4	association	association	NN
cord-006860-a3b8hyyr	1010	5	of	of	IN
cord-006860-a3b8hyyr	1010	6	thrombin	thrombin	NNP
cord-006860-a3b8hyyr	1010	7	with	with	IN
cord-006860-a3b8hyyr	1010	8	phosphorlipid	phosphorlipid	JJ
cord-006860-a3b8hyyr	1010	9	surfaces	surface	NNS
cord-006860-a3b8hyyr	1010	10	.	.	.
cord-006860-a3b8hyyr	1011	1	Recently	recently	RB
cord-006860-a3b8hyyr	1011	2	it	-PRON-	PRP
cord-006860-a3b8hyyr	1011	3	has	have	VBZ
cord-006860-a3b8hyyr	1011	4	been	be	VBN
cord-006860-a3b8hyyr	1011	5	shown	show	VBN
cord-006860-a3b8hyyr	1011	6	that	that	IN
cord-006860-a3b8hyyr	1011	7	a	a	DT
cord-006860-a3b8hyyr	1011	8	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1011	9	of	of	IN
cord-006860-a3b8hyyr	1011	10	PZ	PZ	NNP
cord-006860-a3b8hyyr	1011	11	may	may	MD
cord-006860-a3b8hyyr	1011	12	lead	lead	VB
cord-006860-a3b8hyyr	1011	13	to	to	IN
cord-006860-a3b8hyyr	1011	14	a	a	DT
cord-006860-a3b8hyyr	1011	15	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	1011	16	tendency	tendency	NN
cord-006860-a3b8hyyr	1011	17	.	.	.
cord-006860-a3b8hyyr	1012	1	In	in	IN
cord-006860-a3b8hyyr	1012	2	patients	patient	NNS
cord-006860-a3b8hyyr	1012	3	undergoing	undergo	VBG
cord-006860-a3b8hyyr	1012	4	chronic	chronic	JJ
cord-006860-a3b8hyyr	1012	5	hemodialysis	hemodialysis	NN
cord-006860-a3b8hyyr	1012	6	,	,	,
cord-006860-a3b8hyyr	1012	7	disorders	disorder	NNS
cord-006860-a3b8hyyr	1012	8	of	of	IN
cord-006860-a3b8hyyr	1012	9	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	1012	10	are	be	VBP
cord-006860-a3b8hyyr	1012	11	common	common	JJ
cord-006860-a3b8hyyr	1012	12	.	.	.
cord-006860-a3b8hyyr	1013	1	To	to	TO
cord-006860-a3b8hyyr	1013	2	examine	examine	VB
cord-006860-a3b8hyyr	1013	3	if	if	IN
cord-006860-a3b8hyyr	1013	4	plasma	plasma	NN
cord-006860-a3b8hyyr	1013	5	levels	level	NNS
cord-006860-a3b8hyyr	1013	6	of	of	IN
cord-006860-a3b8hyyr	1013	7	PZ	PZ	NNP
cord-006860-a3b8hyyr	1013	8	are	be	VBP
cord-006860-a3b8hyyr	1013	9	altered	alter	VBN
cord-006860-a3b8hyyr	1013	10	in	in	IN
cord-006860-a3b8hyyr	1013	11	patients	patient	NNS
cord-006860-a3b8hyyr	1013	12	with	with	IN
cord-006860-a3b8hyyr	1013	13	end	end	NN
cord-006860-a3b8hyyr	1013	14	stage	stage	NN
cord-006860-a3b8hyyr	1013	15	renal	renal	JJ
cord-006860-a3b8hyyr	1013	16	disease	disease	NN
cord-006860-a3b8hyyr	1013	17	we	-PRON-	PRP
cord-006860-a3b8hyyr	1013	18	determined	determine	VBD
cord-006860-a3b8hyyr	1013	19	PZ	PZ	NNP
cord-006860-a3b8hyyr	1013	20	in	in	IN
cord-006860-a3b8hyyr	1013	21	plasma	plasma	NN
cord-006860-a3b8hyyr	1013	22	of	of	IN
cord-006860-a3b8hyyr	1013	23	patients	patient	NNS
cord-006860-a3b8hyyr	1013	24	at	at	IN
cord-006860-a3b8hyyr	1013	25	the	the	DT
cord-006860-a3b8hyyr	1013	26	beginning	beginning	NN
cord-006860-a3b8hyyr	1013	27	of	of	IN
cord-006860-a3b8hyyr	1013	28	hemodialysis	hemodialysis	NN
cord-006860-a3b8hyyr	1013	29	treatment	treatment	NN
cord-006860-a3b8hyyr	1013	30	.	.	.
cord-006860-a3b8hyyr	1014	1	The	the	DT
cord-006860-a3b8hyyr	1014	2	results	result	NNS
cord-006860-a3b8hyyr	1014	3	were	be	VBD
cord-006860-a3b8hyyr	1014	4	compared	compare	VBN
cord-006860-a3b8hyyr	1014	5	with	with	IN
cord-006860-a3b8hyyr	1014	6	a	a	DT
cord-006860-a3b8hyyr	1014	7	group	group	NN
cord-006860-a3b8hyyr	1014	8	of	of	IN
cord-006860-a3b8hyyr	1014	9	50	50	CD
cord-006860-a3b8hyyr	1014	10	healthy	healthy	JJ
cord-006860-a3b8hyyr	1014	11	controls	control	NNS
cord-006860-a3b8hyyr	1014	12	.	.	.
cord-006860-a3b8hyyr	1015	1	The	the	DT
cord-006860-a3b8hyyr	1015	2	difference	difference	NN
cord-006860-a3b8hyyr	1015	3	of	of	IN
cord-006860-a3b8hyyr	1015	4	PZ	PZ	NNP
cord-006860-a3b8hyyr	1015	5	levels	level	NNS
cord-006860-a3b8hyyr	1015	6	in	in	IN
cord-006860-a3b8hyyr	1015	7	plasma	plasma	NN
cord-006860-a3b8hyyr	1015	8	of	of	IN
cord-006860-a3b8hyyr	1015	9	patients	patient	NNS
cord-006860-a3b8hyyr	1015	10	with	with	IN
cord-006860-a3b8hyyr	1015	11	end	end	NN
cord-006860-a3b8hyyr	1015	12	stage	stage	NN
cord-006860-a3b8hyyr	1015	13	renal	renal	JJ
cord-006860-a3b8hyyr	1015	14	disease	disease	NN
cord-006860-a3b8hyyr	1015	15	with	with	IN
cord-006860-a3b8hyyr	1015	16	the	the	DT
cord-006860-a3b8hyyr	1015	17	control	control	NN
cord-006860-a3b8hyyr	1015	18	group	group	NN
cord-006860-a3b8hyyr	1015	19	was	be	VBD
cord-006860-a3b8hyyr	1015	20	not	not	RB
cord-006860-a3b8hyyr	1015	21	significant	significant	JJ
cord-006860-a3b8hyyr	1015	22	.	.	.
cord-006860-a3b8hyyr	1016	1	Control	control	NN
cord-006860-a3b8hyyr	1016	2	group	group	NN
cord-006860-a3b8hyyr	1016	3	was	be	VBD
cord-006860-a3b8hyyr	1016	4	2900	2900	CD
cord-006860-a3b8hyyr	1016	5	+	+	SYM
cord-006860-a3b8hyyr	1016	6	487	487	CD
cord-006860-a3b8hyyr	1016	7	ng	ng	NN
cord-006860-a3b8hyyr	1016	8	/	/	SYM
cord-006860-a3b8hyyr	1016	9	ml	ml	NN
cord-006860-a3b8hyyr	1017	1	and	and	CC
cord-006860-a3b8hyyr	1017	2	in	in	IN
cord-006860-a3b8hyyr	1017	3	patient	patient	JJ
cord-006860-a3b8hyyr	1017	4	group	group	NN
cord-006860-a3b8hyyr	1017	5	was	be	VBD
cord-006860-a3b8hyyr	1017	6	3133	3133	CD
cord-006860-a3b8hyyr	1018	1	+	+	CC
cord-006860-a3b8hyyr	1019	1	-1394	-1394	:
cord-006860-a3b8hyyr	1019	2	ng	ng	NNP
cord-006860-a3b8hyyr	1019	3	/	/	SYM
cord-006860-a3b8hyyr	1019	4	ml	ml	NN
cord-006860-a3b8hyyr	1019	5	.	.	.
cord-006860-a3b8hyyr	1020	1	One	one	CD
cord-006860-a3b8hyyr	1020	2	patient	patient	NN
cord-006860-a3b8hyyr	1020	3	with	with	IN
cord-006860-a3b8hyyr	1020	4	marked	marked	JJ
cord-006860-a3b8hyyr	1020	5	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	1020	6	tendency	tendency	NN
cord-006860-a3b8hyyr	1020	7	after	after	IN
cord-006860-a3b8hyyr	1020	8	hemodialysis	hemodialysis	NN
cord-006860-a3b8hyyr	1020	9	PZ	PZ	NNP
cord-006860-a3b8hyyr	1020	10	was	be	VBD
cord-006860-a3b8hyyr	1020	11	1387	1387	CD
cord-006860-a3b8hyyr	1020	12	ng	ng	NN
cord-006860-a3b8hyyr	1020	13	/	/	SYM
cord-006860-a3b8hyyr	1020	14	ml	ml	NN
cord-006860-a3b8hyyr	1020	15	.	.	.
cord-006860-a3b8hyyr	1021	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1021	2	concluded	conclude	VBD
cord-006860-a3b8hyyr	1021	3	that	that	IN
cord-006860-a3b8hyyr	1021	4	patients	patient	NNS
cord-006860-a3b8hyyr	1021	5	with	with	IN
cord-006860-a3b8hyyr	1021	6	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1021	7	disorders	disorder	NNS
cord-006860-a3b8hyyr	1021	8	PZ	PZ	NNP
cord-006860-a3b8hyyr	1021	9	determination	determination	NN
cord-006860-a3b8hyyr	1021	10	may	may	MD
cord-006860-a3b8hyyr	1021	11	be	be	VB
cord-006860-a3b8hyyr	1021	12	helpful	helpful	JJ
cord-006860-a3b8hyyr	1021	13	.	.	.
cord-006860-a3b8hyyr	1022	1	The	the	DT
cord-006860-a3b8hyyr	1022	2	normal	normal	JJ
cord-006860-a3b8hyyr	1022	3	range	range	NN
cord-006860-a3b8hyyr	1022	4	of	of	IN
cord-006860-a3b8hyyr	1022	5	Actin	Actin	NNP
cord-006860-a3b8hyyr	1022	6	FS	FS	NNP
cord-006860-a3b8hyyr	1022	7	was	be	VBD
cord-006860-a3b8hyyr	1022	8	reinvestigated	reinvestigate	VBN
cord-006860-a3b8hyyr	1022	9	in	in	IN
cord-006860-a3b8hyyr	1022	10	a	a	DT
cord-006860-a3b8hyyr	1022	11	multicentric	multicentric	JJ
cord-006860-a3b8hyyr	1022	12	approach	approach	NN
cord-006860-a3b8hyyr	1022	13	.	.	.
cord-006860-a3b8hyyr	1023	1	A	a	DT
cord-006860-a3b8hyyr	1023	2	protocol	protocol	NN
cord-006860-a3b8hyyr	1023	3	was	be	VBD
cord-006860-a3b8hyyr	1023	4	developed	develop	VBN
cord-006860-a3b8hyyr	1023	5	which	which	WDT
cord-006860-a3b8hyyr	1023	6	requests	request	NNS
cord-006860-a3b8hyyr	1023	7	from	from	IN
cord-006860-a3b8hyyr	1023	8	each	each	DT
cord-006860-a3b8hyyr	1023	9	center	center	NN
cord-006860-a3b8hyyr	1023	10	to	to	TO
cord-006860-a3b8hyyr	1023	11	assess	assess	VB
cord-006860-a3b8hyyr	1023	12	the	the	DT
cord-006860-a3b8hyyr	1023	13	aPTT	aptt	NN
cord-006860-a3b8hyyr	1023	14	with	with	IN
cord-006860-a3b8hyyr	1023	15	one	one	CD
cord-006860-a3b8hyyr	1023	16	common	common	JJ
cord-006860-a3b8hyyr	1023	17	and	and	CC
cord-006860-a3b8hyyr	1023	18	one	one	CD
cord-006860-a3b8hyyr	1023	19	variable	variable	JJ
cord-006860-a3b8hyyr	1023	20	lot	lot	NN
cord-006860-a3b8hyyr	1023	21	of	of	IN
cord-006860-a3b8hyyr	1023	22	Actin	Actin	NNP
cord-006860-a3b8hyyr	1023	23	FS	FS	NNP
cord-006860-a3b8hyyr	1023	24	in	in	IN
cord-006860-a3b8hyyr	1023	25	50	50	CD
cord-006860-a3b8hyyr	1023	26	samples	sample	NNS
cord-006860-a3b8hyyr	1023	27	of	of	IN
cord-006860-a3b8hyyr	1023	28	suspected	suspect	VBN
cord-006860-a3b8hyyr	1023	29	normals	normal	NNS
cord-006860-a3b8hyyr	1023	30	.	.	.
cord-006860-a3b8hyyr	1024	1	Inclusion	inclusion	NN
cord-006860-a3b8hyyr	1024	2	and	and	CC
cord-006860-a3b8hyyr	1024	3	exclusion	exclusion	NN
cord-006860-a3b8hyyr	1024	4	criteria	criterion	NNS
cord-006860-a3b8hyyr	1024	5	based	base	VBN
cord-006860-a3b8hyyr	1024	6	upon	upon	IN
cord-006860-a3b8hyyr	1024	7	the	the	DT
cord-006860-a3b8hyyr	1024	8	results	result	NNS
cord-006860-a3b8hyyr	1024	9	of	of	IN
cord-006860-a3b8hyyr	1024	10	clotting	clotting	NN
cord-006860-a3b8hyyr	1024	11	assays	assay	NNS
cord-006860-a3b8hyyr	1024	12	,	,	,
cord-006860-a3b8hyyr	1024	13	liver	liver	NN
cord-006860-a3b8hyyr	1024	14	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	1024	15	and	and	CC
cord-006860-a3b8hyyr	1024	16	clinical	clinical	JJ
cord-006860-a3b8hyyr	1024	17	data	datum	NNS
cord-006860-a3b8hyyr	1024	18	were	be	VBD
cord-006860-a3b8hyyr	1024	19	defined	define	VBN
cord-006860-a3b8hyyr	1024	20	.	.	.
cord-006860-a3b8hyyr	1025	1	Results	result	NNS
cord-006860-a3b8hyyr	1025	2	:	:	:
cord-006860-a3b8hyyr	1026	1	A	a	DT
cord-006860-a3b8hyyr	1026	2	total	total	NN
cord-006860-a3b8hyyr	1026	3	of	of	IN
cord-006860-a3b8hyyr	1026	4	1056	1056	CD
cord-006860-a3b8hyyr	1026	5	results	result	NNS
cord-006860-a3b8hyyr	1026	6	was	be	VBD
cord-006860-a3b8hyyr	1026	7	obtained	obtain	VBN
cord-006860-a3b8hyyr	1026	8	.	.	.
cord-006860-a3b8hyyr	1027	1	The	the	DT
cord-006860-a3b8hyyr	1027	2	majority	majority	NN
cord-006860-a3b8hyyr	1027	3	of	of	IN
cord-006860-a3b8hyyr	1027	4	centers	center	NNS
cord-006860-a3b8hyyr	1027	5	in	in	IN
cord-006860-a3b8hyyr	1027	6	this	this	DT
cord-006860-a3b8hyyr	1027	7	study	study	NN
cord-006860-a3b8hyyr	1027	8	used	use	VBD
cord-006860-a3b8hyyr	1027	9	the	the	DT
cord-006860-a3b8hyyr	1027	10	Electra	Electra	NNP
cord-006860-a3b8hyyr	1027	11	1000	1000	CD
cord-006860-a3b8hyyr	1027	12	or	or	CC
cord-006860-a3b8hyyr	1027	13	1600	1600	CD
cord-006860-a3b8hyyr	1027	14	C	C	NNP
cord-006860-a3b8hyyr	1027	15	(	(	-LRB-
cord-006860-a3b8hyyr	1027	16	MLA	MLA	NNP
cord-006860-a3b8hyyr	1027	17	)	)	-RRB-
cord-006860-a3b8hyyr	1027	18	.	.	.
cord-006860-a3b8hyyr	1028	1	Results	result	NNS
cord-006860-a3b8hyyr	1028	2	for	for	IN
cord-006860-a3b8hyyr	1028	3	the	the	DT
cord-006860-a3b8hyyr	1028	4	Electra	Electra	NNP
cord-006860-a3b8hyyr	1028	5	group	group	NN
cord-006860-a3b8hyyr	1028	6	(	(	-LRB-
cord-006860-a3b8hyyr	1028	7	n	n	NN
cord-006860-a3b8hyyr	1028	8	=	=	SYM
cord-006860-a3b8hyyr	1028	9	6	6	CD
cord-006860-a3b8hyyr	1028	10	)	)	-RRB-
cord-006860-a3b8hyyr	1028	11	showed	show	VBD
cord-006860-a3b8hyyr	1028	12	a	a	DT
cord-006860-a3b8hyyr	1028	13	precision	precision	NN
cord-006860-a3b8hyyr	1028	14	for	for	IN
cord-006860-a3b8hyyr	1028	15	the	the	DT
cord-006860-a3b8hyyr	1028	16	common	common	JJ
cord-006860-a3b8hyyr	1028	17	lot	lot	NN
cord-006860-a3b8hyyr	1028	18	of	of	IN
cord-006860-a3b8hyyr	1028	19	Actin	Actin	NNP
cord-006860-a3b8hyyr	1028	20	FS	FS	NNP
cord-006860-a3b8hyyr	1028	21	with	with	IN
cord-006860-a3b8hyyr	1028	22	a	a	DT
cord-006860-a3b8hyyr	1028	23	common	common	JJ
cord-006860-a3b8hyyr	1028	24	lot	lot	NN
cord-006860-a3b8hyyr	1028	25	of	of	IN
cord-006860-a3b8hyyr	1028	26	a	a	DT
cord-006860-a3b8hyyr	1028	27	three	three	CD
cord-006860-a3b8hyyr	1028	28	level	level	NN
cord-006860-a3b8hyyr	1028	29	control	control	NN
cord-006860-a3b8hyyr	1028	30	from	from	IN
cord-006860-a3b8hyyr	1028	31	1.5	1.5	CD
cord-006860-a3b8hyyr	1028	32	%	%	NN
cord-006860-a3b8hyyr	1028	33	(	(	-LRB-
cord-006860-a3b8hyyr	1028	34	Level	level	NN
cord-006860-a3b8hyyr	1028	35	1	1	CD
cord-006860-a3b8hyyr	1028	36	)	)	-RRB-
cord-006860-a3b8hyyr	1028	37	to	to	IN
cord-006860-a3b8hyyr	1028	38	1.1	1.1	CD
cord-006860-a3b8hyyr	1028	39	%	%	NN
cord-006860-a3b8hyyr	1028	40	(	(	-LRB-
cord-006860-a3b8hyyr	1028	41	level	level	NN
cord-006860-a3b8hyyr	1028	42	3	3	CD
cord-006860-a3b8hyyr	1028	43	)	)	-RRB-
cord-006860-a3b8hyyr	1028	44	with	with	IN
cord-006860-a3b8hyyr	1028	45	an	an	DT
cord-006860-a3b8hyyr	1028	46	excellent	excellent	JJ
cord-006860-a3b8hyyr	1028	47	accuracy	accuracy	NN
cord-006860-a3b8hyyr	1028	48	between	between	IN
cord-006860-a3b8hyyr	1028	49	the	the	DT
cord-006860-a3b8hyyr	1028	50	6	6	CD
cord-006860-a3b8hyyr	1028	51	centers	center	NNS
cord-006860-a3b8hyyr	1028	52	.	.	.
cord-006860-a3b8hyyr	1029	1	Clotting	clot	VBG
cord-006860-a3b8hyyr	1029	2	times	time	NNS
cord-006860-a3b8hyyr	1029	3	with	with	IN
cord-006860-a3b8hyyr	1029	4	the	the	DT
cord-006860-a3b8hyyr	1029	5	variable	variable	JJ
cord-006860-a3b8hyyr	1029	6	lots	lot	NNS
cord-006860-a3b8hyyr	1029	7	of	of	IN
cord-006860-a3b8hyyr	1029	8	Actin	Actin	NNP
cord-006860-a3b8hyyr	1029	9	FS	FS	NNP
cord-006860-a3b8hyyr	1029	10	were	be	VBD
cord-006860-a3b8hyyr	1029	11	very	very	RB
cord-006860-a3b8hyyr	1029	12	similar	similar	JJ
cord-006860-a3b8hyyr	1029	13	.	.	.
cord-006860-a3b8hyyr	1030	1	The	the	DT
cord-006860-a3b8hyyr	1030	2	results	result	NNS
cord-006860-a3b8hyyr	1030	3	from	from	IN
cord-006860-a3b8hyyr	1030	4	normals	normal	NNS
cord-006860-a3b8hyyr	1030	5	,	,	,
cord-006860-a3b8hyyr	1030	6	however	however	RB
cord-006860-a3b8hyyr	1030	7	,	,	,
cord-006860-a3b8hyyr	1030	8	showed	show	VBD
cord-006860-a3b8hyyr	1030	9	a	a	DT
cord-006860-a3b8hyyr	1030	10	somewhat	somewhat	RB
cord-006860-a3b8hyyr	1030	11	higher	high	JJR
cord-006860-a3b8hyyr	1030	12	dispersion	dispersion	NN
cord-006860-a3b8hyyr	1030	13	using	use	VBG
cord-006860-a3b8hyyr	1030	14	the	the	DT
cord-006860-a3b8hyyr	1030	15	common	common	JJ
cord-006860-a3b8hyyr	1030	16	lot	lot	NN
cord-006860-a3b8hyyr	1030	17	of	of	IN
cord-006860-a3b8hyyr	1030	18	Actin	Actin	NNP
cord-006860-a3b8hyyr	1030	19	FS	FS	NNP
cord-006860-a3b8hyyr	1030	20	.	.	.
cord-006860-a3b8hyyr	1031	1	4	4	CD
cord-006860-a3b8hyyr	1031	2	of	of	IN
cord-006860-a3b8hyyr	1031	3	6	6	CD
cord-006860-a3b8hyyr	1031	4	centers	center	NNS
cord-006860-a3b8hyyr	1031	5	had	have	VBD
cord-006860-a3b8hyyr	1031	6	almost	almost	RB
cord-006860-a3b8hyyr	1031	7	identical	identical	JJ
cord-006860-a3b8hyyr	1031	8	mean	mean	JJ
cord-006860-a3b8hyyr	1031	9	values	value	NNS
cord-006860-a3b8hyyr	1031	10	(	(	-LRB-
cord-006860-a3b8hyyr	1031	11	range	range	VB
cord-006860-a3b8hyyr	1031	12	26.6	26.6	CD
cord-006860-a3b8hyyr	1031	13	to	to	IN
cord-006860-a3b8hyyr	1031	14	27.2	27.2	CD
cord-006860-a3b8hyyr	1031	15	sue	sue	NN
cord-006860-a3b8hyyr	1031	16	)	)	-RRB-
cord-006860-a3b8hyyr	1031	17	whereas	whereas	IN
cord-006860-a3b8hyyr	1031	18	one	one	CD
cord-006860-a3b8hyyr	1031	19	reported	report	VBD
cord-006860-a3b8hyyr	1031	20	shorter	short	JJR
cord-006860-a3b8hyyr	1031	21	and	and	CC
cord-006860-a3b8hyyr	1031	22	one	one	CD
cord-006860-a3b8hyyr	1031	23	longer	long	JJR
cord-006860-a3b8hyyr	1031	24	clotting	clot	VBG
cord-006860-a3b8hyyr	1031	25	times	time	NNS
cord-006860-a3b8hyyr	1031	26	(	(	-LRB-
cord-006860-a3b8hyyr	1031	27	25.2	25.2	CD
cord-006860-a3b8hyyr	1031	28	and	and	CC
cord-006860-a3b8hyyr	1031	29	29.7	29.7	CD
cord-006860-a3b8hyyr	1031	30	sec	sec	NNP
cord-006860-a3b8hyyr	1031	31	)	)	-RRB-
cord-006860-a3b8hyyr	1031	32	.	.	.
cord-006860-a3b8hyyr	1032	1	Results	result	NNS
cord-006860-a3b8hyyr	1032	2	with	with	IN
cord-006860-a3b8hyyr	1032	3	the	the	DT
cord-006860-a3b8hyyr	1032	4	variable	variable	JJ
cord-006860-a3b8hyyr	1032	5	lots	lot	NNS
cord-006860-a3b8hyyr	1032	6	gave	give	VBD
cord-006860-a3b8hyyr	1032	7	almost	almost	RB
cord-006860-a3b8hyyr	1032	8	identical	identical	JJ
cord-006860-a3b8hyyr	1032	9	results	result	NNS
cord-006860-a3b8hyyr	1032	10	as	as	IN
cord-006860-a3b8hyyr	1032	11	the	the	DT
cord-006860-a3b8hyyr	1032	12	common	common	JJ
cord-006860-a3b8hyyr	1032	13	one	one	CD
cord-006860-a3b8hyyr	1032	14	.	.	.
cord-006860-a3b8hyyr	1033	1	A	a	DT
cord-006860-a3b8hyyr	1033	2	total	total	NN
cord-006860-a3b8hyyr	1033	3	of	of	IN
cord-006860-a3b8hyyr	1033	4	556	556	CD
cord-006860-a3b8hyyr	1033	5	results	result	NNS
cord-006860-a3b8hyyr	1033	6	of	of	IN
cord-006860-a3b8hyyr	1033	7	all	all	DT
cord-006860-a3b8hyyr	1033	8	lots	lot	NNS
cord-006860-a3b8hyyr	1033	9	gave	give	VBD
cord-006860-a3b8hyyr	1033	10	a	a	DT
cord-006860-a3b8hyyr	1033	11	normal	normal	JJ
cord-006860-a3b8hyyr	1033	12	range	range	NN
cord-006860-a3b8hyyr	1033	13	of	of	IN
cord-006860-a3b8hyyr	1033	14	23.5	23.5	CD
cord-006860-a3b8hyyr	1033	15	to	to	IN
cord-006860-a3b8hyyr	1033	16	31.7	31.7	CD
cord-006860-a3b8hyyr	1033	17	(	(	-LRB-
cord-006860-a3b8hyyr	1033	18	5	5	CD
cord-006860-a3b8hyyr	1033	19	-95	-95	NN
cord-006860-a3b8hyyr	1033	20	%	%	NN
cord-006860-a3b8hyyr	1033	21	percentiles	percentile	NNS
cord-006860-a3b8hyyr	1033	22	)	)	-RRB-
cord-006860-a3b8hyyr	1033	23	on	on	IN
cord-006860-a3b8hyyr	1033	24	Electra	Electra	NNP
cord-006860-a3b8hyyr	1033	25	.	.	.
cord-006860-a3b8hyyr	1034	1	Mean	mean	JJ
cord-006860-a3b8hyyr	1034	2	values	value	NNS
cord-006860-a3b8hyyr	1034	3	on	on	IN
cord-006860-a3b8hyyr	1034	4	ACL	ACL	NNP
cord-006860-a3b8hyyr	1034	5	(	(	-LRB-
cord-006860-a3b8hyyr	1034	6	n	n	NN
cord-006860-a3b8hyyr	1034	7	=	=	SYM
cord-006860-a3b8hyyr	1034	8	200	200	CD
cord-006860-a3b8hyyr	1034	9	)	)	-RRB-
cord-006860-a3b8hyyr	1034	10	were	be	VBD
cord-006860-a3b8hyyr	1034	11	26.3	26.3	CD
cord-006860-a3b8hyyr	1034	12	,	,	,
cord-006860-a3b8hyyr	1034	13	on	on	IN
cord-006860-a3b8hyyr	1034	14	BCT	BCT	NNP
cord-006860-a3b8hyyr	1034	15	,	,	,
cord-006860-a3b8hyyr	1034	16	27.65	27.65	CD
cord-006860-a3b8hyyr	1034	17	sec	sec	NNP
cord-006860-a3b8hyyr	1034	18	,	,	,
cord-006860-a3b8hyyr	1034	19	on	on	IN
cord-006860-a3b8hyyr	1034	20	AMGA	AMGA	NNP
cord-006860-a3b8hyyr	1034	21	coagulometric	coagulometric	NNP
cord-006860-a3b8hyyr	1034	22	,	,	,
cord-006860-a3b8hyyr	1034	23	29.4	29.4	CD
cord-006860-a3b8hyyr	1034	24	sec	sec	NNP
cord-006860-a3b8hyyr	1034	25	,	,	,
cord-006860-a3b8hyyr	1034	26	on	on	IN
cord-006860-a3b8hyyr	1034	27	AMGA	AMGA	NNP
cord-006860-a3b8hyyr	1034	28	turbidimetric	turbidimetric	NNP
cord-006860-a3b8hyyr	1034	29	,	,	,
cord-006860-a3b8hyyr	1034	30	26.6	26.6	CD
cord-006860-a3b8hyyr	1034	31	sec	sec	NNP
cord-006860-a3b8hyyr	1034	32	(	(	-LRB-
cord-006860-a3b8hyyr	1034	33	n	n	NN
cord-006860-a3b8hyyr	1034	34	=	=	SYM
cord-006860-a3b8hyyr	1034	35	100	100	CD
cord-006860-a3b8hyyr	1034	36	each	each	DT
cord-006860-a3b8hyyr	1034	37	)	)	-RRB-
cord-006860-a3b8hyyr	1034	38	.	.	.
cord-006860-a3b8hyyr	1035	1	All	all	DT
cord-006860-a3b8hyyr	1035	2	centers	center	NNS
cord-006860-a3b8hyyr	1035	3	used	use	VBD
cord-006860-a3b8hyyr	1035	4	Sarstedt	Sarstedt	NNP
cord-006860-a3b8hyyr	1035	5	monovettes	monovette	NNS
cord-006860-a3b8hyyr	1035	6	with	with	IN
cord-006860-a3b8hyyr	1035	7	3.2	3.2	CD
cord-006860-a3b8hyyr	1035	8	sodium	sodium	NN
cord-006860-a3b8hyyr	1035	9	citrate	citrate	NN
cord-006860-a3b8hyyr	1035	10	.	.	.
cord-006860-a3b8hyyr	1036	1	Discussion	discussion	NN
cord-006860-a3b8hyyr	1036	2	:	:	:
cord-006860-a3b8hyyr	1037	1	The	the	DT
cord-006860-a3b8hyyr	1037	2	results	result	NNS
cord-006860-a3b8hyyr	1037	3	of	of	IN
cord-006860-a3b8hyyr	1037	4	this	this	DT
cord-006860-a3b8hyyr	1037	5	study	study	NN
cord-006860-a3b8hyyr	1037	6	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	1037	7	the	the	DT
cord-006860-a3b8hyyr	1037	8	lot	lot	NN
cord-006860-a3b8hyyr	1037	9	to	to	IN
cord-006860-a3b8hyyr	1037	10	lot	lot	NN
cord-006860-a3b8hyyr	1037	11	consistency	consistency	NN
cord-006860-a3b8hyyr	1037	12	of	of	IN
cord-006860-a3b8hyyr	1037	13	all	all	DT
cord-006860-a3b8hyyr	1037	14	lots	lot	NNS
cord-006860-a3b8hyyr	1037	15	of	of	IN
cord-006860-a3b8hyyr	1037	16	reagents	reagent	NNS
cord-006860-a3b8hyyr	1037	17	included	include	VBN
cord-006860-a3b8hyyr	1037	18	in	in	IN
cord-006860-a3b8hyyr	1037	19	this	this	DT
cord-006860-a3b8hyyr	1037	20	study	study	NN
cord-006860-a3b8hyyr	1037	21	since	since	IN
cord-006860-a3b8hyyr	1037	22	the	the	DT
cord-006860-a3b8hyyr	1037	23	common	common	JJ
cord-006860-a3b8hyyr	1037	24	and	and	CC
cord-006860-a3b8hyyr	1037	25	variable	variable	JJ
cord-006860-a3b8hyyr	1037	26	lots	lot	NNS
cord-006860-a3b8hyyr	1037	27	showed	show	VBD
cord-006860-a3b8hyyr	1037	28	very	very	RB
cord-006860-a3b8hyyr	1037	29	consistent	consistent	JJ
cord-006860-a3b8hyyr	1037	30	results	result	NNS
cord-006860-a3b8hyyr	1037	31	.	.	.
cord-006860-a3b8hyyr	1038	1	Interestingly	interestingly	RB
cord-006860-a3b8hyyr	1038	2	in	in	IN
cord-006860-a3b8hyyr	1038	3	the	the	DT
cord-006860-a3b8hyyr	1038	4	large	large	JJ
cord-006860-a3b8hyyr	1038	5	group	group	NN
cord-006860-a3b8hyyr	1038	6	of	of	IN
cord-006860-a3b8hyyr	1038	7	Electra	Electra	NNP
cord-006860-a3b8hyyr	1038	8	users	user	NNS
cord-006860-a3b8hyyr	1038	9	the	the	DT
cord-006860-a3b8hyyr	1038	10	normal	normal	JJ
cord-006860-a3b8hyyr	1038	11	ranges	range	NNS
cord-006860-a3b8hyyr	1038	12	showed	show	VBD
cord-006860-a3b8hyyr	1038	13	some	some	DT
cord-006860-a3b8hyyr	1038	14	differences	difference	NNS
cord-006860-a3b8hyyr	1038	15	,	,	,
cord-006860-a3b8hyyr	1038	16	though	though	IN
cord-006860-a3b8hyyr	1038	17	the	the	DT
cord-006860-a3b8hyyr	1038	18	controls	control	NNS
cord-006860-a3b8hyyr	1038	19	in	in	IN
cord-006860-a3b8hyyr	1038	20	all	all	DT
cord-006860-a3b8hyyr	1038	21	centers	center	NNS
cord-006860-a3b8hyyr	1038	22	were	be	VBD
cord-006860-a3b8hyyr	1038	23	almost	almost	RB
cord-006860-a3b8hyyr	1038	24	identical	identical	JJ
cord-006860-a3b8hyyr	1038	25	.	.	.
cord-006860-a3b8hyyr	1039	1	This	this	DT
cord-006860-a3b8hyyr	1039	2	confirms	confirm	VBZ
cord-006860-a3b8hyyr	1039	3	the	the	DT
cord-006860-a3b8hyyr	1039	4	recommendation	recommendation	NN
cord-006860-a3b8hyyr	1039	5	that	that	IN
cord-006860-a3b8hyyr	1039	6	a	a	DT
cord-006860-a3b8hyyr	1039	7	normal	normal	JJ
cord-006860-a3b8hyyr	1039	8	range	range	NN
cord-006860-a3b8hyyr	1039	9	as	as	IN
cord-006860-a3b8hyyr	1039	10	stated	state	VBN
cord-006860-a3b8hyyr	1039	11	from	from	IN
cord-006860-a3b8hyyr	1039	12	the	the	DT
cord-006860-a3b8hyyr	1039	13	manufacturer	manufacturer	NN
cord-006860-a3b8hyyr	1039	14	should	should	MD
cord-006860-a3b8hyyr	1039	15	be	be	VB
cord-006860-a3b8hyyr	1039	16	used	use	VBN
cord-006860-a3b8hyyr	1039	17	for	for	IN
cord-006860-a3b8hyyr	1039	18	orientation	orientation	NN
cord-006860-a3b8hyyr	1039	19	only	only	RB
cord-006860-a3b8hyyr	1039	20	and	and	CC
cord-006860-a3b8hyyr	1039	21	that	that	IN
cord-006860-a3b8hyyr	1039	22	each	each	DT
cord-006860-a3b8hyyr	1039	23	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1039	24	should	should	MD
cord-006860-a3b8hyyr	1039	25	assess	assess	VB
cord-006860-a3b8hyyr	1039	26	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1039	27	own	own	JJ
cord-006860-a3b8hyyr	1039	28	range	range	NN
cord-006860-a3b8hyyr	1039	29	.	.	.
cord-006860-a3b8hyyr	1040	1	Direct	direct	JJ
cord-006860-a3b8hyyr	1040	2	acting	act	VBG
cord-006860-a3b8hyyr	1040	3	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	1040	4	agents	agent	NNS
cord-006860-a3b8hyyr	1040	5	such	such	JJ
cord-006860-a3b8hyyr	1040	6	as	as	IN
cord-006860-a3b8hyyr	1040	7	hirudin	hirudin	NN
cord-006860-a3b8hyyr	1040	8	(	(	-LRB-
cord-006860-a3b8hyyr	1040	9	r	r	NN
cord-006860-a3b8hyyr	1040	10	-	-	HYPH
cord-006860-a3b8hyyr	1040	11	H	H	NNP
cord-006860-a3b8hyyr	1040	12	)	)	-RRB-
cord-006860-a3b8hyyr	1040	13	,	,	,
cord-006860-a3b8hyyr	1040	14	argatroban	argatroban	NNP
cord-006860-a3b8hyyr	1040	15	(	(	-LRB-
cord-006860-a3b8hyyr	1040	16	Arg	Arg	NNP
cord-006860-a3b8hyyr	1040	17	)	)	-RRB-
cord-006860-a3b8hyyr	1040	18	,	,	,
cord-006860-a3b8hyyr	1040	19	efegatran	efegatran	NN
cord-006860-a3b8hyyr	1040	20	(	(	-LRB-
cord-006860-a3b8hyyr	1040	21	Efe	Efe	NNP
cord-006860-a3b8hyyr	1040	22	)	)	-RRB-
cord-006860-a3b8hyyr	1040	23	and	and	CC
cord-006860-a3b8hyyr	1040	24	PEG	peg	NN
cord-006860-a3b8hyyr	1040	25	-	-	HYPH
cord-006860-a3b8hyyr	1040	26	hirudin	hirudin	NN
cord-006860-a3b8hyyr	1040	27	(	(	-LRB-
cord-006860-a3b8hyyr	1040	28	PH	PH	NNP
cord-006860-a3b8hyyr	1040	29	)	)	-RRB-
cord-006860-a3b8hyyr	1040	30	,	,	,
cord-006860-a3b8hyyr	1040	31	represent	represent	VBP
cord-006860-a3b8hyyr	1040	32	specific	specific	JJ
cord-006860-a3b8hyyr	1040	33	and	and	CC
cord-006860-a3b8hyyr	1040	34	potent	potent	JJ
cord-006860-a3b8hyyr	1040	35	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1040	36	of	of	IN
cord-006860-a3b8hyyr	1040	37	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1040	38	.	.	.
cord-006860-a3b8hyyr	1041	1	Blood	blood	NN
cord-006860-a3b8hyyr	1041	2	samples	sample	NNS
cord-006860-a3b8hyyr	1041	3	collected	collect	VBN
cord-006860-a3b8hyyr	1041	4	in	in	IN
cord-006860-a3b8hyyr	1041	5	r	r	NN
cord-006860-a3b8hyyr	1041	6	-	-	HYPH
cord-006860-a3b8hyyr	1041	7	H	h	NN
cord-006860-a3b8hyyr	1041	8	(	(	-LRB-
cord-006860-a3b8hyyr	1041	9	10	10	CD
cord-006860-a3b8hyyr	1041	10	~g	~g	NNP
cord-006860-a3b8hyyr	1041	11	/	/	SYM
cord-006860-a3b8hyyr	1041	12	ml	ml	NN
cord-006860-a3b8hyyr	1041	13	)	)	-RRB-
cord-006860-a3b8hyyr	1041	14	,	,	.
cord-006860-a3b8hyyr	1042	1	Arg	Arg	NNP
cord-006860-a3b8hyyr	1042	2	(	(	-LRB-
cord-006860-a3b8hyyr	1042	3	50	50	CD
cord-006860-a3b8hyyr	1042	4	~tg	~tg	NNS
cord-006860-a3b8hyyr	1042	5	/	/	SYM
cord-006860-a3b8hyyr	1042	6	ml	ml	NN
cord-006860-a3b8hyyr	1042	7	)	)	-RRB-
cord-006860-a3b8hyyr	1042	8	,	,	,
cord-006860-a3b8hyyr	1042	9	Efe	Efe	NNP
cord-006860-a3b8hyyr	1042	10	(	(	-LRB-
cord-006860-a3b8hyyr	1042	11	25	25	CD
cord-006860-a3b8hyyr	1042	12	~tg	~tg	NNS
cord-006860-a3b8hyyr	1042	13	/	/	SYM
cord-006860-a3b8hyyr	1042	14	ml	ml	NN
cord-006860-a3b8hyyr	1042	15	)	)	-RRB-
cord-006860-a3b8hyyr	1042	16	and	and	CC
cord-006860-a3b8hyyr	1042	17	PH	PH	NNP
cord-006860-a3b8hyyr	1042	18	(	(	-LRB-
cord-006860-a3b8hyyr	1042	19	10	10	CD
cord-006860-a3b8hyyr	1042	20	~tg	~tg	NNS
cord-006860-a3b8hyyr	1042	21	/	/	SYM
cord-006860-a3b8hyyr	1042	22	ml	ml	NN
cord-006860-a3b8hyyr	1042	23	)	)	-RRB-
cord-006860-a3b8hyyr	1042	24	do	do	VBP
cord-006860-a3b8hyyr	1042	25	not	not	RB
cord-006860-a3b8hyyr	1042	26	clot	clot	VB
cord-006860-a3b8hyyr	1042	27	for	for	IN
cord-006860-a3b8hyyr	1042	28	extended	extended	JJ
cord-006860-a3b8hyyr	1042	29	periods	period	NNS
cord-006860-a3b8hyyr	1042	30	(	(	-LRB-
cord-006860-a3b8hyyr	1042	31	>	>	NFP
cord-006860-a3b8hyyr	1042	32	24	24	CD
cord-006860-a3b8hyyr	1042	33	hours	hour	NNS
cord-006860-a3b8hyyr	1042	34	)	)	-RRB-
cord-006860-a3b8hyyr	1042	35	,	,	,
cord-006860-a3b8hyyr	1042	36	thus	thus	RB
cord-006860-a3b8hyyr	1042	37	allowing	allow	VBG
cord-006860-a3b8hyyr	1042	38	for	for	IN
cord-006860-a3b8hyyr	1042	39	the	the	DT
cord-006860-a3b8hyyr	1042	40	collection	collection	NN
cord-006860-a3b8hyyr	1042	41	of	of	IN
cord-006860-a3b8hyyr	1042	42	plasma	plasma	NN
cord-006860-a3b8hyyr	1042	43	for	for	IN
cord-006860-a3b8hyyr	1042	44	analytical	analytical	JJ
cord-006860-a3b8hyyr	1042	45	purposes	purpose	NNS
cord-006860-a3b8hyyr	1042	46	.	.	.
cord-006860-a3b8hyyr	1043	1	Unlike	unlike	IN
cord-006860-a3b8hyyr	1043	2	heparin	heparin	NN
cord-006860-a3b8hyyr	1043	3	,	,	,
cord-006860-a3b8hyyr	1043	4	these	these	DT
cord-006860-a3b8hyyr	1043	5	agents	agent	NNS
cord-006860-a3b8hyyr	1043	6	do	do	VBP
cord-006860-a3b8hyyr	1043	7	not	not	RB
cord-006860-a3b8hyyr	1043	8	require	require	VB
cord-006860-a3b8hyyr	1043	9	any	any	DT
cord-006860-a3b8hyyr	1043	10	plasma	plasma	NN
cord-006860-a3b8hyyr	1043	11	cofactor	cofactor	NN
cord-006860-a3b8hyyr	1043	12	for	for	IN
cord-006860-a3b8hyyr	1043	13	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1043	14	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	1043	15	effect	effect	NN
cord-006860-a3b8hyyr	1043	16	.	.	.
cord-006860-a3b8hyyr	1044	1	In	in	IN
cord-006860-a3b8hyyr	1044	2	contrast	contrast	NN
cord-006860-a3b8hyyr	1044	3	to	to	IN
cord-006860-a3b8hyyr	1044	4	citrate	citrate	NN
cord-006860-a3b8hyyr	1044	5	,	,	,
cord-006860-a3b8hyyr	1044	6	oxalate	oxalate	NN
cord-006860-a3b8hyyr	1044	7	,	,	,
cord-006860-a3b8hyyr	1044	8	EDTA	EDTA	NNP
cord-006860-a3b8hyyr	1044	9	and	and	CC
cord-006860-a3b8hyyr	1044	10	heparin	heparin	NN
cord-006860-a3b8hyyr	1044	11	,	,	,
cord-006860-a3b8hyyr	1044	12	these	these	DT
cord-006860-a3b8hyyr	1044	13	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	1044	14	agents	agent	NNS
cord-006860-a3b8hyyr	1044	15	do	do	VBP
cord-006860-a3b8hyyr	1044	16	not	not	RB
cord-006860-a3b8hyyr	1044	17	alter	alter	VB
cord-006860-a3b8hyyr	1044	18	the	the	DT
cord-006860-a3b8hyyr	1044	19	electrolyte	electrolyte	NN
cord-006860-a3b8hyyr	1044	20	or	or	CC
cord-006860-a3b8hyyr	1044	21	protein	protein	NN
cord-006860-a3b8hyyr	1044	22	composition	composition	NN
cord-006860-a3b8hyyr	1044	23	of	of	IN
cord-006860-a3b8hyyr	1044	24	blood	blood	NN
cord-006860-a3b8hyyr	1044	25	.	.	.
cord-006860-a3b8hyyr	1045	1	Thus	thus	RB
cord-006860-a3b8hyyr	1045	2	,	,	,
cord-006860-a3b8hyyr	1045	3	blood	blood	NN
cord-006860-a3b8hyyr	1045	4	collected	collect	VBN
cord-006860-a3b8hyyr	1045	5	in	in	IN
cord-006860-a3b8hyyr	1045	6	these	these	DT
cord-006860-a3b8hyyr	1045	7	agents	agent	NNS
cord-006860-a3b8hyyr	1045	8	may	may	MD
cord-006860-a3b8hyyr	1045	9	provide	provide	VB
cord-006860-a3b8hyyr	1045	10	a	a	DT
cord-006860-a3b8hyyr	1045	11	physiologically	physiologically	RB
cord-006860-a3b8hyyr	1045	12	intact	intact	JJ
cord-006860-a3b8hyyr	1045	13	(	(	-LRB-
cord-006860-a3b8hyyr	1045	14	native	native	JJ
cord-006860-a3b8hyyr	1045	15	)	)	-RRB-
cord-006860-a3b8hyyr	1045	16	sample	sample	NN
cord-006860-a3b8hyyr	1045	17	for	for	IN
cord-006860-a3b8hyyr	1045	18	clinical	clinical	JJ
cord-006860-a3b8hyyr	1045	19	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1045	20	profiling	profiling	NN
cord-006860-a3b8hyyr	1045	21	.	.	.
cord-006860-a3b8hyyr	1046	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1046	2	have	have	VBP
cord-006860-a3b8hyyr	1046	3	used	use	VBN
cord-006860-a3b8hyyr	1046	4	all	all	DT
cord-006860-a3b8hyyr	1046	5	of	of	IN
cord-006860-a3b8hyyr	1046	6	these	these	DT
cord-006860-a3b8hyyr	1046	7	agents	agent	NNS
cord-006860-a3b8hyyr	1046	8	to	to	TO
cord-006860-a3b8hyyr	1046	9	prepare	prepare	VB
cord-006860-a3b8hyyr	1046	10	whole	whole	JJ
cord-006860-a3b8hyyr	1046	11	blood	blood	NN
cord-006860-a3b8hyyr	1046	12	and	and	CC
cord-006860-a3b8hyyr	1046	13	plasma	plasma	NN
cord-006860-a3b8hyyr	1046	14	samples	sample	NNS
cord-006860-a3b8hyyr	1046	15	for	for	IN
cord-006860-a3b8hyyr	1046	16	various	various	JJ
cord-006860-a3b8hyyr	1046	17	diuical	diuical	JJ
cord-006860-a3b8hyyr	1046	18	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1046	19	measuroments	measuroment	NNS
cord-006860-a3b8hyyr	1046	20	.	.	.
cord-006860-a3b8hyyr	1047	1	Plasma	plasma	NN
cord-006860-a3b8hyyr	1047	2	samples	sample	NNS
cord-006860-a3b8hyyr	1047	3	collected	collect	VBN
cord-006860-a3b8hyyr	1047	4	with	with	IN
cord-006860-a3b8hyyr	1047	5	these	these	DT
cord-006860-a3b8hyyr	1047	6	agents	agent	NNS
cord-006860-a3b8hyyr	1047	7	are	be	VBP
cord-006860-a3b8hyyr	1047	8	obviously	obviously	RB
cord-006860-a3b8hyyr	1047	9	not	not	RB
cord-006860-a3b8hyyr	1047	10	suitable	suitable	JJ
cord-006860-a3b8hyyr	1047	11	for	for	IN
cord-006860-a3b8hyyr	1047	12	global	global	JJ
cord-006860-a3b8hyyr	1047	13	clotting	clotting	NN
cord-006860-a3b8hyyr	1047	14	tests	test	NNS
cord-006860-a3b8hyyr	1047	15	(	(	-LRB-
cord-006860-a3b8hyyr	1047	16	PT	PT	NNP
cord-006860-a3b8hyyr	1047	17	,	,	,
cord-006860-a3b8hyyr	1047	18	APTT	APTT	NNP
cord-006860-a3b8hyyr	1047	19	,	,	,
cord-006860-a3b8hyyr	1047	20	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1047	21	time	time	NN
cord-006860-a3b8hyyr	1047	22	,	,	,
cord-006860-a3b8hyyr	1047	23	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1047	24	)	)	-RRB-
cord-006860-a3b8hyyr	1047	25	;	;	:
cord-006860-a3b8hyyr	1047	26	however	however	RB
cord-006860-a3b8hyyr	1047	27	,	,	,
cord-006860-a3b8hyyr	1047	28	these	these	DT
cord-006860-a3b8hyyr	1047	29	agents	agent	NNS
cord-006860-a3b8hyyr	1047	30	are	be	VBP
cord-006860-a3b8hyyr	1047	31	optimal	optimal	JJ
cord-006860-a3b8hyyr	1047	32	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	1047	33	for	for	IN
cord-006860-a3b8hyyr	1047	34	the	the	DT
cord-006860-a3b8hyyr	1047	35	collection	collection	NN
cord-006860-a3b8hyyr	1047	36	of	of	IN
cord-006860-a3b8hyyr	1047	37	samples	sample	NNS
cord-006860-a3b8hyyr	1047	38	for	for	IN
cord-006860-a3b8hyyr	1047	39	the	the	DT
cord-006860-a3b8hyyr	1047	40	molecular	molecular	JJ
cord-006860-a3b8hyyr	1047	41	markers	marker	NNS
cord-006860-a3b8hyyr	1047	42	of	of	IN
cord-006860-a3b8hyyr	1047	43	hemostatie	hemostatie	NN
cord-006860-a3b8hyyr	1047	44	activation	activation	NN
cord-006860-a3b8hyyr	1047	45	,	,	,
cord-006860-a3b8hyyr	1047	46	such	such	JJ
cord-006860-a3b8hyyr	1047	47	as	as	IN
cord-006860-a3b8hyyr	1047	48	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1047	49	/	/	SYM
cord-006860-a3b8hyyr	1047	50	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1047	51	related	relate	VBN
cord-006860-a3b8hyyr	1047	52	degradation	degradation	NN
cord-006860-a3b8hyyr	1047	53	products	product	NNS
cord-006860-a3b8hyyr	1047	54	,	,	,
cord-006860-a3b8hyyr	1047	55	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	1047	56	fragment	fragment	NN
cord-006860-a3b8hyyr	1047	57	,	,	,
cord-006860-a3b8hyyr	1047	58	protease	protease	NN
cord-006860-a3b8hyyr	1047	59	cleavage	cleavage	NN
cord-006860-a3b8hyyr	1047	60	products	product	NNS
cord-006860-a3b8hyyr	1047	61	,	,	,
cord-006860-a3b8hyyr	1047	62	TFPI	TFPI	NNP
cord-006860-a3b8hyyr	1047	63	,	,	,
cord-006860-a3b8hyyr	1047	64	TNF	TNF	NNP
cord-006860-a3b8hyyr	1047	65	and	and	CC
cord-006860-a3b8hyyr	1047	66	other	other	JJ
cord-006860-a3b8hyyr	1047	67	protein	protein	NN
cord-006860-a3b8hyyr	1047	68	mediators	mediator	NNS
cord-006860-a3b8hyyr	1047	69	.	.	.
cord-006860-a3b8hyyr	1048	1	Electrolytes	electrolyte	NNS
cord-006860-a3b8hyyr	1048	2	,	,	,
cord-006860-a3b8hyyr	1048	3	blood	blood	NN
cord-006860-a3b8hyyr	1048	4	gases	gas	NNS
cord-006860-a3b8hyyr	1048	5	,	,	,
cord-006860-a3b8hyyr	1048	6	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	1048	7	and	and	CC
cord-006860-a3b8hyyr	1048	8	protein	protein	NN
cord-006860-a3b8hyyr	1048	9	profiling	profiling	NN
cord-006860-a3b8hyyr	1048	10	can	can	MD
cord-006860-a3b8hyyr	1048	11	also	also	RB
cord-006860-a3b8hyyr	1048	12	be	be	VB
cord-006860-a3b8hyyr	1048	13	satisfactorily	satisfactorily	RB
cord-006860-a3b8hyyr	1048	14	measured	measure	VBN
cord-006860-a3b8hyyr	1048	15	on	on	IN
cord-006860-a3b8hyyr	1048	16	blood	blood	NN
cord-006860-a3b8hyyr	1048	17	samples	sample	NNS
cord-006860-a3b8hyyr	1048	18	collected	collect	VBN
cord-006860-a3b8hyyr	1048	19	with	with	IN
cord-006860-a3b8hyyr	1048	20	these	these	DT
cord-006860-a3b8hyyr	1048	21	agents	agent	NNS
cord-006860-a3b8hyyr	1048	22	.	.	.
cord-006860-a3b8hyyr	1049	1	Antithrombin	Antithrombin	NNP
cord-006860-a3b8hyyr	1049	2	anticoagelatad	anticoagelatad	NN
cord-006860-a3b8hyyr	1049	3	blood	blood	NN
cord-006860-a3b8hyyr	1049	4	used	use	VBD
cord-006860-a3b8hyyr	1049	5	fur	fur	NN
cord-006860-a3b8hyyr	1049	6	hematologic	hematologic	JJ
cord-006860-a3b8hyyr	1049	7	analysis	analysis	NN
cord-006860-a3b8hyyr	1049	8	showed	show	VBD
cord-006860-a3b8hyyr	1049	9	equivalent	equivalent	JJ
cord-006860-a3b8hyyr	1049	10	blood	blood	NN
cord-006860-a3b8hyyr	1049	11	count	count	NN
cord-006860-a3b8hyyr	1049	12	and	and	CC
cord-006860-a3b8hyyr	1049	13	differential	differential	JJ
cord-006860-a3b8hyyr	1049	14	results	result	NNS
cord-006860-a3b8hyyr	1049	15	as	as	IN
cord-006860-a3b8hyyr	1049	16	that	that	WDT
cord-006860-a3b8hyyr	1049	17	obtained	obtain	VBN
cord-006860-a3b8hyyr	1049	18	with	with	IN
cord-006860-a3b8hyyr	1049	19	EDTA	EDTA	NNP
cord-006860-a3b8hyyr	1049	20	blood	blood	NN
cord-006860-a3b8hyyr	1049	21	.	.	.
cord-006860-a3b8hyyr	1050	1	Unlike	unlike	IN
cord-006860-a3b8hyyr	1050	2	other	other	JJ
cord-006860-a3b8hyyr	1050	3	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	1050	4	,	,	,
cord-006860-a3b8hyyr	1050	5	these	these	DT
cord-006860-a3b8hyyr	1050	6	agents	agent	NNS
cord-006860-a3b8hyyr	1050	7	do	do	VBP
cord-006860-a3b8hyyr	1050	8	not	not	RB
cord-006860-a3b8hyyr	1050	9	interfere	interfere	VB
cord-006860-a3b8hyyr	1050	10	in	in	IN
cord-006860-a3b8hyyr	1050	11	the	the	DT
cord-006860-a3b8hyyr	1050	12	cell	cell	NN
cord-006860-a3b8hyyr	1050	13	staining	staining	NN
cord-006860-a3b8hyyr	1050	14	process	process	NN
cord-006860-a3b8hyyr	1050	15	.	.	.
cord-006860-a3b8hyyr	1051	1	Washed	wash	VBN
cord-006860-a3b8hyyr	1051	2	blood	blood	NN
cord-006860-a3b8hyyr	1051	3	cells	cell	NNS
cord-006860-a3b8hyyr	1051	4	can	can	MD
cord-006860-a3b8hyyr	1051	5	also	also	RB
cord-006860-a3b8hyyr	1051	6	be	be	VB
cord-006860-a3b8hyyr	1051	7	prepared	prepare	VBN
cord-006860-a3b8hyyr	1051	8	using	use	VBG
cord-006860-a3b8hyyr	1051	9	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	1051	10	aents	aent	NNS
cord-006860-a3b8hyyr	1051	11	supplemented	supplement	VBD
cord-006860-a3b8hyyr	1051	12	buffers	buffer	NNS
cord-006860-a3b8hyyr	1051	13	for	for	IN
cord-006860-a3b8hyyr	1051	14	morphologic	morphologic	JJ
cord-006860-a3b8hyyr	1051	15	and	and	CC
cord-006860-a3b8hyyr	1051	16	fuuctional	fuuctional	JJ
cord-006860-a3b8hyyr	1051	17	studies	study	NNS
cord-006860-a3b8hyyr	1051	18	.	.	.
cord-006860-a3b8hyyr	1052	1	Thrombin	Thrombin	NNP
cord-006860-a3b8hyyr	1052	2	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1052	3	such	such	JJ
cord-006860-a3b8hyyr	1052	4	as	as	IN
cord-006860-a3b8hyyr	1052	5	hirudin	hirudin	NN
cord-006860-a3b8hyyr	1052	6	have	have	VBP
cord-006860-a3b8hyyr	1052	7	also	also	RB
cord-006860-a3b8hyyr	1052	8	been	be	VBN
cord-006860-a3b8hyyr	1052	9	used	use	VBN
cord-006860-a3b8hyyr	1052	10	for	for	IN
cord-006860-a3b8hyyr	1052	11	flow	flow	NN
cord-006860-a3b8hyyr	1052	12	cytometry	cytometry	NN
cord-006860-a3b8hyyr	1052	13	and	and	CC
cord-006860-a3b8hyyr	1052	14	image	image	NN
cord-006860-a3b8hyyr	1052	15	analysis	analysis	NN
cord-006860-a3b8hyyr	1052	16	of	of	IN
cord-006860-a3b8hyyr	1052	17	blood	blood	NN
cord-006860-a3b8hyyr	1052	18	cells	cell	NNS
cord-006860-a3b8hyyr	1052	19	and	and	CC
cord-006860-a3b8hyyr	1052	20	tissue	tissue	NN
cord-006860-a3b8hyyr	1052	21	exudates	exudate	NNS
cord-006860-a3b8hyyr	1052	22	.	.	.
cord-006860-a3b8hyyr	1053	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	1053	2	observations	observation	NNS
cord-006860-a3b8hyyr	1053	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	1053	4	that	that	IN
cord-006860-a3b8hyyr	1053	5	these	these	DT
cord-006860-a3b8hyyr	1053	6	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	1053	7	can	can	MD
cord-006860-a3b8hyyr	1053	8	be	be	VB
cord-006860-a3b8hyyr	1053	9	used	use	VBN
cord-006860-a3b8hyyr	1053	10	as	as	IN
cord-006860-a3b8hyyr	1053	11	suitable	suitable	JJ
cord-006860-a3b8hyyr	1053	12	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	1053	13	for	for	IN
cord-006860-a3b8hyyr	1053	14	clinical	clinical	JJ
cord-006860-a3b8hyyr	1053	15	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1053	16	blood	blood	NN
cord-006860-a3b8hyyr	1053	17	sampling	sampling	NN
cord-006860-a3b8hyyr	1053	18	.	.	.
cord-006860-a3b8hyyr	1054	1	These	these	DT
cord-006860-a3b8hyyr	1054	2	agents	agent	NNS
cord-006860-a3b8hyyr	1054	3	can	can	MD
cord-006860-a3b8hyyr	1054	4	also	also	RB
cord-006860-a3b8hyyr	1054	5	be	be	VB
cord-006860-a3b8hyyr	1054	6	used	use	VBN
cord-006860-a3b8hyyr	1054	7	as	as	IN
cord-006860-a3b8hyyr	1054	8	a	a	DT
cord-006860-a3b8hyyr	1054	9	flush	flush	JJ
cord-006860-a3b8hyyr	1054	10	anticoagnlant	anticoagnlant	JJ
cord-006860-a3b8hyyr	1054	11	fur	fur	NN
cord-006860-a3b8hyyr	1054	12	most	most	RBS
cord-006860-a3b8hyyr	1054	13	automated	automate	VBN
cord-006860-a3b8hyyr	1054	14	instruments	instrument	NNS
cord-006860-a3b8hyyr	1054	15	as	as	IN
cord-006860-a3b8hyyr	1054	16	these	these	DT
cord-006860-a3b8hyyr	1054	17	exhibit	exhibit	VBP
cord-006860-a3b8hyyr	1054	18	superior	superior	JJ
cord-006860-a3b8hyyr	1054	19	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	1054	20	properties	property	NNS
cord-006860-a3b8hyyr	1054	21	to	to	IN
cord-006860-a3b8hyyr	1054	22	heparin	heparin	VB
cord-006860-a3b8hyyr	1054	23	.	.	.
cord-006860-a3b8hyyr	1055	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	1055	2	,	,	,
cord-006860-a3b8hyyr	1055	3	the	the	DT
cord-006860-a3b8hyyr	1055	4	hematologic	hematologic	JJ
cord-006860-a3b8hyyr	1055	5	parameters	parameter	NNS
cord-006860-a3b8hyyr	1055	6	obtained	obtain	VBN
cord-006860-a3b8hyyr	1055	7	in	in	IN
cord-006860-a3b8hyyr	1055	8	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	1055	9	anticeagnlated	anticeagnlate	VBN
cord-006860-a3b8hyyr	1055	10	blood	blood	NN
cord-006860-a3b8hyyr	1055	11	may	may	MD
cord-006860-a3b8hyyr	1055	12	be	be	VB
cord-006860-a3b8hyyr	1055	13	physiologically	physiologically	RB
cord-006860-a3b8hyyr	1055	14	more	more	RBR
cord-006860-a3b8hyyr	1055	15	relevant	relevant	JJ
cord-006860-a3b8hyyr	1055	16	than	than	IN
cord-006860-a3b8hyyr	1055	17	those	those	DT
cord-006860-a3b8hyyr	1055	18	determined	determine	VBN
cord-006860-a3b8hyyr	1055	19	on	on	IN
cord-006860-a3b8hyyr	1055	20	blood	blood	NN
cord-006860-a3b8hyyr	1055	21	collected	collect	VBN
cord-006860-a3b8hyyr	1055	22	in	in	IN
cord-006860-a3b8hyyr	1055	23	EDTA	EDTA	NNP
cord-006860-a3b8hyyr	1055	24	,	,	,
cord-006860-a3b8hyyr	1055	25	citrate	citrate	NN
cord-006860-a3b8hyyr	1055	26	or	or	CC
cord-006860-a3b8hyyr	1055	27	heparin	heparin	NN
cord-006860-a3b8hyyr	1055	28	.	.	.
cord-006860-a3b8hyyr	1056	1	Antithrombin	Antithrombin	NNP
cord-006860-a3b8hyyr	1056	2	Ul	Ul	NNP
cord-006860-a3b8hyyr	1056	3	determination	determination	NN
cord-006860-a3b8hyyr	1056	4	is	be	VBZ
cord-006860-a3b8hyyr	1056	5	one	one	CD
cord-006860-a3b8hyyr	1056	6	of	of	IN
cord-006860-a3b8hyyr	1056	7	the	the	DT
cord-006860-a3b8hyyr	1056	8	most	most	RBS
cord-006860-a3b8hyyr	1056	9	popular	popular	JJ
cord-006860-a3b8hyyr	1056	10	method	method	NN
cord-006860-a3b8hyyr	1056	11	for	for	IN
cord-006860-a3b8hyyr	1056	12	in	in	FW
cord-006860-a3b8hyyr	1056	13	vitro	vitro	FW
cord-006860-a3b8hyyr	1056	14	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	1056	15	of	of	IN
cord-006860-a3b8hyyr	1056	16	number	number	NN
cord-006860-a3b8hyyr	1056	17	of	of	IN
cord-006860-a3b8hyyr	1056	18	different	different	JJ
cord-006860-a3b8hyyr	1056	19	disorders	disorder	NNS
cord-006860-a3b8hyyr	1056	20	.	.	.
cord-006860-a3b8hyyr	1057	1	Human	human	JJ
cord-006860-a3b8hyyr	1057	2	fhrombin	fhrombin	NN
cord-006860-a3b8hyyr	1058	1	a	a	LS
cord-006860-a3b8hyyr	1058	2	~	~	NFP
cord-006860-a3b8hyyr	1058	3	nity	nity	NN
cord-006860-a3b8hyyr	1058	4	purified	purify	VBN
cord-006860-a3b8hyyr	1058	5	on	on	IN
cord-006860-a3b8hyyr	1058	6	heparin	heparin	NN
cord-006860-a3b8hyyr	1058	7	-	-	HYPH
cord-006860-a3b8hyyr	1058	8	rnodified	rnodifie	VBN
cord-006860-a3b8hyyr	1058	9	silica	silica	NN
cord-006860-a3b8hyyr	1058	10	-	-	HYPH
cord-006860-a3b8hyyr	1058	11	based	base	VBN
cord-006860-a3b8hyyr	1058	12	sorbents	sorbent	NNS
cord-006860-a3b8hyyr	1058	13	was	be	VBD
cord-006860-a3b8hyyr	1058	14	used	use	VBN
cord-006860-a3b8hyyr	1058	15	for	for	IN
cord-006860-a3b8hyyr	1058	16	level	level	NN
cord-006860-a3b8hyyr	1058	17	of	of	IN
cord-006860-a3b8hyyr	1058	18	antithrombine	antithrombine	NN
cord-006860-a3b8hyyr	1058	19	lU	lU	NNP
cord-006860-a3b8hyyr	1058	20	determination	determination	NN
cord-006860-a3b8hyyr	1058	21	by	by	IN
cord-006860-a3b8hyyr	1058	22	Abilgaard	Abilgaard	NNP
cord-006860-a3b8hyyr	1058	23	method	method	NN
cord-006860-a3b8hyyr	1058	24	in	in	IN
cord-006860-a3b8hyyr	1058	25	blood	blood	NN
cord-006860-a3b8hyyr	1058	26	of	of	IN
cord-006860-a3b8hyyr	1058	27	40	40	CD
cord-006860-a3b8hyyr	1058	28	patients	patient	NNS
cord-006860-a3b8hyyr	1058	29	with	with	IN
cord-006860-a3b8hyyr	1058	30	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	1058	31	pathology	pathology	NN
cord-006860-a3b8hyyr	1058	32	,	,	,
cord-006860-a3b8hyyr	1058	33	acute	acute	JJ
cord-006860-a3b8hyyr	1058	34	leukemia	leukemia	NN
cord-006860-a3b8hyyr	1058	35	,	,	,
cord-006860-a3b8hyyr	1058	36	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	1058	37	and	and	CC
cord-006860-a3b8hyyr	1058	38	anemia	anemia	NN
cord-006860-a3b8hyyr	1058	39	.	.	.
cord-006860-a3b8hyyr	1059	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1059	2	was	be	VBD
cord-006860-a3b8hyyr	1059	3	founded	found	VBN
cord-006860-a3b8hyyr	1059	4	,	,	,
cord-006860-a3b8hyyr	1059	5	that	that	IN
cord-006860-a3b8hyyr	1059	6	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	1059	7	level	level	NN
cord-006860-a3b8hyyr	1059	8	is	be	VBZ
cord-006860-a3b8hyyr	1059	9	decreased	decrease	VBN
cord-006860-a3b8hyyr	1059	10	to	to	IN
cord-006860-a3b8hyyr	1059	11	50	50	CD
cord-006860-a3b8hyyr	1059	12	-	-	SYM
cord-006860-a3b8hyyr	1059	13	60	60	CD
cord-006860-a3b8hyyr	1059	14	%	%	NN
cord-006860-a3b8hyyr	1059	15	of	of	IN
cord-006860-a3b8hyyr	1059	16	normal	normal	JJ
cord-006860-a3b8hyyr	1059	17	values	value	NNS
cord-006860-a3b8hyyr	1059	18	in	in	IN
cord-006860-a3b8hyyr	1059	19	case	case	NN
cord-006860-a3b8hyyr	1059	20	of	of	IN
cord-006860-a3b8hyyr	1059	21	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	1059	22	pathology	pathology	NN
cord-006860-a3b8hyyr	1059	23	,	,	,
cord-006860-a3b8hyyr	1059	24	to	to	IN
cord-006860-a3b8hyyr	1059	25	<	<	XX
cord-006860-a3b8hyyr	1059	26	50	50	CD
cord-006860-a3b8hyyr	1059	27	%	%	NN
cord-006860-a3b8hyyr	1059	28	-in	-in	CD
cord-006860-a3b8hyyr	1059	29	case	case	NN
cord-006860-a3b8hyyr	1059	30	of	of	IN
cord-006860-a3b8hyyr	1059	31	acute	acute	JJ
cord-006860-a3b8hyyr	1059	32	leukemia	leukemia	NN
cord-006860-a3b8hyyr	1059	33	and	and	CC
cord-006860-a3b8hyyr	1059	34	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	1059	35	,	,	,
cord-006860-a3b8hyyr	1059	36	to	to	IN
cord-006860-a3b8hyyr	1059	37	S0	s0	NN
cord-006860-a3b8hyyr	1059	38	%	%	NN
cord-006860-a3b8hyyr	1059	39	-in	-in	IN
cord-006860-a3b8hyyr	1059	40	case	case	NN
cord-006860-a3b8hyyr	1059	41	of	of	IN
cord-006860-a3b8hyyr	1059	42	anemia	anemia	NN
cord-006860-a3b8hyyr	1059	43	.	.	.
cord-006860-a3b8hyyr	1060	1	Obtained	obtain	VBN
cord-006860-a3b8hyyr	1060	2	results	result	NNS
cord-006860-a3b8hyyr	1060	3	show	show	VBP
cord-006860-a3b8hyyr	1060	4	the	the	DT
cord-006860-a3b8hyyr	1060	5	strong	strong	JJ
cord-006860-a3b8hyyr	1060	6	relationships	relationship	NNS
cord-006860-a3b8hyyr	1060	7	between	between	IN
cord-006860-a3b8hyyr	1060	8	named	name	VBN
cord-006860-a3b8hyyr	1060	9	disorders	disorder	NNS
cord-006860-a3b8hyyr	1060	10	and	and	CC
cord-006860-a3b8hyyr	1060	11	patient	patient	JJ
cord-006860-a3b8hyyr	1060	12	antifhrombin	antifhrombin	NNP
cord-006860-a3b8hyyr	1060	13	III	iii	CD
cord-006860-a3b8hyyr	1060	14	level	level	NN
cord-006860-a3b8hyyr	1060	15	.	.	.
cord-006860-a3b8hyyr	1061	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	1061	2	anfifhrombine	anfifhrombine	JJ
cord-006860-a3b8hyyr	1061	3	III	iii	CD
cord-006860-a3b8hyyr	1061	4	estimation	estimation	NN
cord-006860-a3b8hyyr	1061	5	may	may	MD
cord-006860-a3b8hyyr	1061	6	be	be	VB
cord-006860-a3b8hyyr	1061	7	used	use	VBN
cord-006860-a3b8hyyr	1061	8	as	as	IN
cord-006860-a3b8hyyr	1061	9	simple	simple	JJ
cord-006860-a3b8hyyr	1061	10	and	and	CC
cord-006860-a3b8hyyr	1061	11	quick	quick	JJ
cord-006860-a3b8hyyr	1061	12	method	method	NN
cord-006860-a3b8hyyr	1061	13	for	for	IN
cord-006860-a3b8hyyr	1061	14	preliminary	preliminary	JJ
cord-006860-a3b8hyyr	1061	15	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	1061	16	of	of	IN
cord-006860-a3b8hyyr	1061	17	above	above	RB
cord-006860-a3b8hyyr	1061	18	named	name	VBN
cord-006860-a3b8hyyr	1061	19	disorders	disorder	NNS
cord-006860-a3b8hyyr	1061	20	.	.	.
cord-006860-a3b8hyyr	1062	1	BM	BM	NNP
cord-006860-a3b8hyyr	1062	2	Coasys	Coasys	NNP
cord-006860-a3b8hyyr	1062	3	110	110	CD
cord-006860-a3b8hyyr	1062	4	is	be	VBZ
cord-006860-a3b8hyyr	1062	5	a	a	DT
cord-006860-a3b8hyyr	1062	6	complete	complete	JJ
cord-006860-a3b8hyyr	1062	7	automated	automated	JJ
cord-006860-a3b8hyyr	1062	8	analyzer	analyzer	NN
cord-006860-a3b8hyyr	1062	9	system	system	NN
cord-006860-a3b8hyyr	1062	10	for	for	IN
cord-006860-a3b8hyyr	1062	11	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1062	12	tests	test	NNS
cord-006860-a3b8hyyr	1062	13	.	.	.
cord-006860-a3b8hyyr	1063	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1063	2	is	be	VBZ
cord-006860-a3b8hyyr	1063	3	well	well	RB
cord-006860-a3b8hyyr	1063	4	suited	suited	JJ
cord-006860-a3b8hyyr	1063	5	for	for	IN
cord-006860-a3b8hyyr	1063	6	routine	routine	JJ
cord-006860-a3b8hyyr	1063	7	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1063	8	testing	testing	NN
cord-006860-a3b8hyyr	1063	9	in	in	IN
cord-006860-a3b8hyyr	1063	10	random	random	JJ
cord-006860-a3b8hyyr	1063	11	access	access	NN
cord-006860-a3b8hyyr	1063	12	in	in	IN
cord-006860-a3b8hyyr	1063	13	a	a	DT
cord-006860-a3b8hyyr	1063	14	medium	medium	NN
cord-006860-a3b8hyyr	1063	15	throughput	throughput	NN
cord-006860-a3b8hyyr	1063	16	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1063	17	environment	environment	NN
cord-006860-a3b8hyyr	1063	18	.	.	.
cord-006860-a3b8hyyr	1064	1	Analytical	analytical	JJ
cord-006860-a3b8hyyr	1064	2	performance	performance	NN
cord-006860-a3b8hyyr	1064	3	and	and	CC
cord-006860-a3b8hyyr	1064	4	practicability	practicability	NN
cord-006860-a3b8hyyr	1064	5	were	be	VBD
cord-006860-a3b8hyyr	1064	6	tested	test	VBN
cord-006860-a3b8hyyr	1064	7	by	by	IN
cord-006860-a3b8hyyr	1064	8	a	a	DT
cord-006860-a3b8hyyr	1064	9	common	common	JJ
cord-006860-a3b8hyyr	1064	10	evaluation	evaluation	NN
cord-006860-a3b8hyyr	1064	11	program	program	NN
cord-006860-a3b8hyyr	1064	12	in	in	IN
cord-006860-a3b8hyyr	1064	13	five	five	CD
cord-006860-a3b8hyyr	1064	14	hospital	hospital	NN
cord-006860-a3b8hyyr	1064	15	laboratories	laboratory	NNS
cord-006860-a3b8hyyr	1064	16	.	.	.
cord-006860-a3b8hyyr	1065	1	Within	within	IN
cord-006860-a3b8hyyr	1065	2	run	run	NN
cord-006860-a3b8hyyr	1065	3	and	and	CC
cord-006860-a3b8hyyr	1065	4	day	day	NN
cord-006860-a3b8hyyr	1065	5	to	to	IN
cord-006860-a3b8hyyr	1065	6	day	day	NN
cord-006860-a3b8hyyr	1065	7	CV	CV	NNP
cord-006860-a3b8hyyr	1065	8	's	's	POS
cord-006860-a3b8hyyr	1065	9	were	be	VBD
cord-006860-a3b8hyyr	1065	10	below	below	IN
cord-006860-a3b8hyyr	1065	11	5	5	CD
cord-006860-a3b8hyyr	1065	12	%	%	NN
cord-006860-a3b8hyyr	1065	13	in	in	IN
cord-006860-a3b8hyyr	1065	14	different	different	JJ
cord-006860-a3b8hyyr	1065	15	samples	sample	NNS
cord-006860-a3b8hyyr	1065	16	(	(	-LRB-
cord-006860-a3b8hyyr	1065	17	controls	control	NNS
cord-006860-a3b8hyyr	1065	18	,	,	,
cord-006860-a3b8hyyr	1065	19	patients	patient	NNS
cord-006860-a3b8hyyr	1065	20	)	)	-RRB-
cord-006860-a3b8hyyr	1065	21	.	.	.
cord-006860-a3b8hyyr	1066	1	Comparison	comparison	NN
cord-006860-a3b8hyyr	1066	2	in	in	IN
cord-006860-a3b8hyyr	1066	3	different	different	JJ
cord-006860-a3b8hyyr	1066	4	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	1066	5	ranges	range	NNS
cord-006860-a3b8hyyr	1066	6	confirms	confirm	VBZ
cord-006860-a3b8hyyr	1066	7	the	the	DT
cord-006860-a3b8hyyr	1066	8	declaration	declaration	NN
cord-006860-a3b8hyyr	1066	9	of	of	IN
cord-006860-a3b8hyyr	1066	10	the	the	DT
cord-006860-a3b8hyyr	1066	11	ISI	ISI	NNP
cord-006860-a3b8hyyr	1066	12	-	-	HYPH
cord-006860-a3b8hyyr	1066	13	value	value	NN
cord-006860-a3b8hyyr	1066	14	for	for	IN
cord-006860-a3b8hyyr	1066	15	calculating	calculate	VBG
cord-006860-a3b8hyyr	1066	16	INR	INR	NNP
cord-006860-a3b8hyyr	1066	17	-	-	HYPH
cord-006860-a3b8hyyr	1066	18	values	value	NNS
cord-006860-a3b8hyyr	1066	19	.	.	.
cord-006860-a3b8hyyr	1067	1	Normal	normal	JJ
cord-006860-a3b8hyyr	1067	2	values	value	NNS
cord-006860-a3b8hyyr	1067	3	for	for	IN
cord-006860-a3b8hyyr	1067	4	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1067	5	tests	test	NNS
cord-006860-a3b8hyyr	1067	6	with	with	IN
cord-006860-a3b8hyyr	1067	7	results	result	NNS
cord-006860-a3b8hyyr	1067	8	in	in	IN
cord-006860-a3b8hyyr	1067	9	pdmary	pdmary	JJ
cord-006860-a3b8hyyr	1067	10	units	unit	NNS
cord-006860-a3b8hyyr	1067	11	were	be	VBD
cord-006860-a3b8hyyr	1067	12	checked	check	VBN
cord-006860-a3b8hyyr	1067	13	in	in	IN
cord-006860-a3b8hyyr	1067	14	390	390	CD
cord-006860-a3b8hyyr	1067	15	samples	sample	NNS
cord-006860-a3b8hyyr	1067	16	and	and	CC
cord-006860-a3b8hyyr	1067	17	confirmed	confirm	VBD
cord-006860-a3b8hyyr	1067	18	.	.	.
cord-006860-a3b8hyyr	1068	1	Due	due	IN
cord-006860-a3b8hyyr	1068	2	to	to	IN
cord-006860-a3b8hyyr	1068	3	the	the	DT
cord-006860-a3b8hyyr	1068	4	optical	optical	JJ
cord-006860-a3b8hyyr	1068	5	measuring	measuring	NN
cord-006860-a3b8hyyr	1068	6	principle	principle	NN
cord-006860-a3b8hyyr	1068	7	of	of	IN
cord-006860-a3b8hyyr	1068	8	the	the	DT
cord-006860-a3b8hyyr	1068	9	BM	BM	NNP
cord-006860-a3b8hyyr	1068	10	Coasys	Coasys	NNP
cord-006860-a3b8hyyr	1068	11	110	110	CD
cord-006860-a3b8hyyr	1068	12	there	there	EX
cord-006860-a3b8hyyr	1068	13	was	be	VBD
cord-006860-a3b8hyyr	1068	14	a	a	DT
cord-006860-a3b8hyyr	1068	15	little	little	JJ
cord-006860-a3b8hyyr	1068	16	tendency	tendency	NN
cord-006860-a3b8hyyr	1068	17	to	to	TO
cord-006860-a3b8hyyr	1068	18	shorter	short	JJR
cord-006860-a3b8hyyr	1068	19	times	time	NNS
cord-006860-a3b8hyyr	1068	20	with	with	IN
cord-006860-a3b8hyyr	1068	21	the	the	DT
cord-006860-a3b8hyyr	1068	22	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1068	23	reagent	reagent	NN
cord-006860-a3b8hyyr	1068	24	.	.	.
cord-006860-a3b8hyyr	1069	1	In	in	IN
cord-006860-a3b8hyyr	1069	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	1069	3	the	the	DT
cord-006860-a3b8hyyr	1069	4	performance	performance	NN
cord-006860-a3b8hyyr	1069	5	of	of	IN
cord-006860-a3b8hyyr	1069	6	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1069	7	tests	test	NNS
cord-006860-a3b8hyyr	1069	8	with	with	IN
cord-006860-a3b8hyyr	1069	9	the	the	DT
cord-006860-a3b8hyyr	1069	10	BM	BM	NNP
cord-006860-a3b8hyyr	1069	11	Coasys	Coasys	NNP
cord-006860-a3b8hyyr	1069	12	110	110	CD
cord-006860-a3b8hyyr	1069	13	was	be	VBD
cord-006860-a3b8hyyr	1069	14	rated	rate	VBN
cord-006860-a3b8hyyr	1069	15	as	as	RB
cord-006860-a3b8hyyr	1069	16	well	well	RB
cord-006860-a3b8hyyr	1069	17	or	or	CC
cord-006860-a3b8hyyr	1069	18	better	well	JJR
cord-006860-a3b8hyyr	1069	19	compared	compare	VBN
cord-006860-a3b8hyyr	1069	20	to	to	IN
cord-006860-a3b8hyyr	1069	21	existing	exist	VBG
cord-006860-a3b8hyyr	1069	22	systems	system	NNS
cord-006860-a3b8hyyr	1069	23	in	in	IN
cord-006860-a3b8hyyr	1069	24	the	the	DT
cord-006860-a3b8hyyr	1069	25	laboratories	laboratory	NNS
cord-006860-a3b8hyyr	1069	26	with	with	IN
cord-006860-a3b8hyyr	1069	27	advantages	advantage	NNS
cord-006860-a3b8hyyr	1069	28	due	due	JJ
cord-006860-a3b8hyyr	1069	29	to	to	IN
cord-006860-a3b8hyyr	1069	30	short	short	JJ
cord-006860-a3b8hyyr	1069	31	timed	time	VBN
cord-006860-a3b8hyyr	1069	32	familiarizing	familiarizing	NN
cord-006860-a3b8hyyr	1069	33	and	and	CC
cord-006860-a3b8hyyr	1069	34	easy	easy	JJ
cord-006860-a3b8hyyr	1069	35	handling	handling	NN
cord-006860-a3b8hyyr	1069	36	.	.	.
cord-006860-a3b8hyyr	1070	1	Flexibility	flexibility	NN
cord-006860-a3b8hyyr	1070	2	and	and	CC
cord-006860-a3b8hyyr	1070	3	stability	stability	NN
cord-006860-a3b8hyyr	1070	4	of	of	IN
cord-006860-a3b8hyyr	1070	5	the	the	DT
cord-006860-a3b8hyyr	1070	6	system	system	NN
cord-006860-a3b8hyyr	1070	7	permit	permit	VBP
cord-006860-a3b8hyyr	1070	8	optimal	optimal	JJ
cord-006860-a3b8hyyr	1070	9	integration	integration	NN
cord-006860-a3b8hyyr	1070	10	and	and	CC
cord-006860-a3b8hyyr	1070	11	innovation	innovation	NN
cord-006860-a3b8hyyr	1070	12	into	into	IN
cord-006860-a3b8hyyr	1070	13	the	the	DT
cord-006860-a3b8hyyr	1070	14	w0rkflow	w0rkflow	NNP
cord-006860-a3b8hyyr	1070	15	of	of	IN
cord-006860-a3b8hyyr	1070	16	the	the	DT
cord-006860-a3b8hyyr	1070	17	routine	routine	JJ
cord-006860-a3b8hyyr	1070	18	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1070	19	.	.	.
cord-006860-a3b8hyyr	1071	1	The	the	DT
cord-006860-a3b8hyyr	1071	2	purified	purify	VBN
cord-006860-a3b8hyyr	1071	3	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1071	4	and	and	CC
cord-006860-a3b8hyyr	1071	5	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	1071	6	III	III	NNP
cord-006860-a3b8hyyr	1071	7	(	(	-LRB-
cord-006860-a3b8hyyr	1071	8	AT	at	IN
cord-006860-a3b8hyyr	1071	9	III	III	NNP
cord-006860-a3b8hyyr	1071	10	)	)	-RRB-
cord-006860-a3b8hyyr	1071	11	have	have	VBP
cord-006860-a3b8hyyr	1071	12	a	a	DT
cord-006860-a3b8hyyr	1071	13	great	great	JJ
cord-006860-a3b8hyyr	1071	14	interest	interest	NN
cord-006860-a3b8hyyr	1071	15	in	in	IN
cord-006860-a3b8hyyr	1071	16	the	the	DT
cord-006860-a3b8hyyr	1071	17	clinical	clinical	JJ
cord-006860-a3b8hyyr	1071	18	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	1071	19	and	and	CC
cord-006860-a3b8hyyr	1071	20	treatment	treatment	NN
cord-006860-a3b8hyyr	1071	21	practice	practice	NN
cord-006860-a3b8hyyr	1071	22	,	,	,
cord-006860-a3b8hyyr	1071	23	so	so	IN
cord-006860-a3b8hyyr	1071	24	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1071	25	isolation	isolation	NN
cord-006860-a3b8hyyr	1071	26	methods	method	NNS
cord-006860-a3b8hyyr	1071	27	are	be	VBP
cord-006860-a3b8hyyr	1071	28	very	very	RB
cord-006860-a3b8hyyr	1071	29	important	important	JJ
cord-006860-a3b8hyyr	1071	30	.	.	.
cord-006860-a3b8hyyr	1072	1	Molecules	molecule	NNS
cord-006860-a3b8hyyr	1072	2	of	of	IN
cord-006860-a3b8hyyr	1072	3	these	these	DT
cord-006860-a3b8hyyr	1072	4	proteins	protein	NNS
cord-006860-a3b8hyyr	1072	5	have	have	VBP
cord-006860-a3b8hyyr	1072	6	some	some	DT
cord-006860-a3b8hyyr	1072	7	fragments	fragment	NNS
cord-006860-a3b8hyyr	1072	8	replying	reply	VBG
cord-006860-a3b8hyyr	1072	9	for	for	IN
cord-006860-a3b8hyyr	1072	10	interaction	interaction	NN
cord-006860-a3b8hyyr	1072	11	with	with	IN
cord-006860-a3b8hyyr	1072	12	native	native	JJ
cord-006860-a3b8hyyr	1072	13	glycosaminoglycan	glycosaminoglycan	NN
cord-006860-a3b8hyyr	1072	14	,	,	,
cord-006860-a3b8hyyr	1072	15	heparin	heparin	NNP
cord-006860-a3b8hyyr	1072	16	.	.	.
cord-006860-a3b8hyyr	1073	1	This	this	DT
cord-006860-a3b8hyyr	1073	2	interaction	interaction	NN
cord-006860-a3b8hyyr	1073	3	is	be	VBZ
cord-006860-a3b8hyyr	1073	4	used	use	VBN
cord-006860-a3b8hyyr	1073	5	for	for	IN
cord-006860-a3b8hyyr	1073	6	isolation	isolation	NN
cord-006860-a3b8hyyr	1073	7	and	and	CC
cord-006860-a3b8hyyr	1073	8	purification	purification	NN
cord-006860-a3b8hyyr	1073	9	of	of	IN
cord-006860-a3b8hyyr	1073	10	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1073	11	and	and	CC
cord-006860-a3b8hyyr	1073	12	AT	at	IN
cord-006860-a3b8hyyr	1073	13	Ul	Ul	NNP
cord-006860-a3b8hyyr	1073	14	from	from	IN
cord-006860-a3b8hyyr	1073	15	native	native	JJ
cord-006860-a3b8hyyr	1073	16	materials	material	NNS
cord-006860-a3b8hyyr	1073	17	,	,	,
cord-006860-a3b8hyyr	1073	18	blood	blood	NN
cord-006860-a3b8hyyr	1073	19	plasma	plasma	NN
cord-006860-a3b8hyyr	1073	20	or	or	CC
cord-006860-a3b8hyyr	1073	21	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1073	22	fractional	fractional	JJ
cord-006860-a3b8hyyr	1073	23	products	product	NNS
cord-006860-a3b8hyyr	1073	24	.	.	.
cord-006860-a3b8hyyr	1074	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1074	2	have	have	VBP
cord-006860-a3b8hyyr	1074	3	done	do	VBN
cord-006860-a3b8hyyr	1074	4	comparative	comparative	JJ
cord-006860-a3b8hyyr	1074	5	studying	study	VBG
cord-006860-a3b8hyyr	1074	6	these	these	DT
cord-006860-a3b8hyyr	1074	7	proteins	protein	NNS
cord-006860-a3b8hyyr	1074	8	purification	purification	NN
cord-006860-a3b8hyyr	1074	9	on	on	IN
cord-006860-a3b8hyyr	1074	10	heparin	heparin	NNP
cord-006860-a3b8hyyr	1074	11	sorbenfs	sorbenfs	NNP
cord-006860-a3b8hyyr	1074	12	,	,	,
cord-006860-a3b8hyyr	1074	13	which	which	WDT
cord-006860-a3b8hyyr	1074	14	contain	contain	VBP
cord-006860-a3b8hyyr	1074	15	heparin	heparin	NN
cord-006860-a3b8hyyr	1074	16	immobilized	immobilize	VBN
cord-006860-a3b8hyyr	1074	17	on	on	IN
cord-006860-a3b8hyyr	1074	18	sificagel	sificagel	NNS
cord-006860-a3b8hyyr	1074	19	,	,	,
cord-006860-a3b8hyyr	1074	20	modified	modify	VBN
cord-006860-a3b8hyyr	1074	21	by	by	IN
cord-006860-a3b8hyyr	1074	22	glycidooxipropyl	glycidooxipropyl	NNP
cord-006860-a3b8hyyr	1074	23	,	,	,
cord-006860-a3b8hyyr	1074	24	gamma	gamma	NNP
cord-006860-a3b8hyyr	1074	25	-	-	HYPH
cord-006860-a3b8hyyr	1074	26	aminopropyl	aminopropyl	NNP
cord-006860-a3b8hyyr	1074	27	and	and	CC
cord-006860-a3b8hyyr	1074	28	tosyl	tosyl	NN
cord-006860-a3b8hyyr	1074	29	chloride	chloride	NN
cord-006860-a3b8hyyr	1074	30	groups	group	NNS
cord-006860-a3b8hyyr	1074	31	,	,	,
cord-006860-a3b8hyyr	1074	32	or	or	CC
cord-006860-a3b8hyyr	1074	33	on	on	IN
cord-006860-a3b8hyyr	1074	34	cellulose	cellulose	NN
cord-006860-a3b8hyyr	1074	35	:	:	:
cord-006860-a3b8hyyr	1074	36	heparin	heparin	NN
cord-006860-a3b8hyyr	1074	37	-	-	HYPH
cord-006860-a3b8hyyr	1074	38	epoxy	epoxy	NN
cord-006860-a3b8hyyr	1074	39	-	-	HYPH
cord-006860-a3b8hyyr	1074	40	silica	silica	NN
cord-006860-a3b8hyyr	1074	41	(	(	-LRB-
cord-006860-a3b8hyyr	1074	42	1	1	CD
cord-006860-a3b8hyyr	1074	43	)	)	-RRB-
cord-006860-a3b8hyyr	1074	44	,	,	,
cord-006860-a3b8hyyr	1074	45	heparin	heparin	NN
cord-006860-a3b8hyyr	1074	46	-	-	HYPH
cord-006860-a3b8hyyr	1074	47	gammapropyl	gammapropyl	NN
cord-006860-a3b8hyyr	1074	48	-	-	HYPH
cord-006860-a3b8hyyr	1074	49	silica	silica	NN
cord-006860-a3b8hyyr	1074	50	(	(	-LRB-
cord-006860-a3b8hyyr	1074	51	2	2	CD
cord-006860-a3b8hyyr	1074	52	)	)	-RRB-
cord-006860-a3b8hyyr	1074	53	,	,	,
cord-006860-a3b8hyyr	1074	54	heparJn	heparJn	NNP
cord-006860-a3b8hyyr	1074	55	-	-	HYPH
cord-006860-a3b8hyyr	1074	56	tozylsilica	tozylsilica	NNP
cord-006860-a3b8hyyr	1074	57	(	(	-LRB-
cord-006860-a3b8hyyr	1074	58	3	3	CD
cord-006860-a3b8hyyr	1074	59	)	)	-RRB-
cord-006860-a3b8hyyr	1074	60	,	,	,
cord-006860-a3b8hyyr	1074	61	and	and	CC
cord-006860-a3b8hyyr	1074	62	heparin	heparin	NN
cord-006860-a3b8hyyr	1074	63	-	-	HYPH
cord-006860-a3b8hyyr	1074	64	cellulose	cellulose	NN
cord-006860-a3b8hyyr	1074	65	(	(	-LRB-
cord-006860-a3b8hyyr	1074	66	4	4	CD
cord-006860-a3b8hyyr	1074	67	)	)	-RRB-
cord-006860-a3b8hyyr	1074	68	.	.	.
cord-006860-a3b8hyyr	1075	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1075	2	founded	found	VBD
cord-006860-a3b8hyyr	1075	3	that	that	IN
cord-006860-a3b8hyyr	1075	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1075	5	binds	bind	VBZ
cord-006860-a3b8hyyr	1075	6	with	with	IN
cord-006860-a3b8hyyr	1075	7	all	all	DT
cord-006860-a3b8hyyr	1075	8	sorbents	sorbent	NNS
cord-006860-a3b8hyyr	1075	9	,	,	,
cord-006860-a3b8hyyr	1075	10	while	while	IN
cord-006860-a3b8hyyr	1075	11	AT	AT	NNP
cord-006860-a3b8hyyr	1075	12	III	III	NNP
cord-006860-a3b8hyyr	1075	13	does	do	VBZ
cord-006860-a3b8hyyr	1075	14	n't	not	RB
cord-006860-a3b8hyyr	1075	15	binds	bind	VBZ
cord-006860-a3b8hyyr	1075	16	with	with	IN
cord-006860-a3b8hyyr	1075	17	sorbents	sorbent	NNS
cord-006860-a3b8hyyr	1075	18	2	2	CD
cord-006860-a3b8hyyr	1075	19	and	and	CC
cord-006860-a3b8hyyr	1075	20	3	3	CD
cord-006860-a3b8hyyr	1075	21	.	.	.
cord-006860-a3b8hyyr	1076	1	There	there	EX
cord-006860-a3b8hyyr	1076	2	was	be	VBD
cord-006860-a3b8hyyr	1076	3	n't	not	RB
cord-006860-a3b8hyyr	1076	4	any	any	DT
cord-006860-a3b8hyyr	1076	5	difference	difference	NN
cord-006860-a3b8hyyr	1076	6	between	between	IN
cord-006860-a3b8hyyr	1076	7	silica	silica	NN
cord-006860-a3b8hyyr	1076	8	and	and	CC
cord-006860-a3b8hyyr	1076	9	cellulose	cellulose	NN
cord-006860-a3b8hyyr	1076	10	sorbents	sorbent	NNS
cord-006860-a3b8hyyr	1076	11	in	in	IN
cord-006860-a3b8hyyr	1076	12	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1076	13	desorbfion	desorbfion	NN
cord-006860-a3b8hyyr	1076	14	by	by	IN
cord-006860-a3b8hyyr	1076	15	t	t	NNP
cord-006860-a3b8hyyr	1076	16	M	M	NNP
cord-006860-a3b8hyyr	1076	17	NaCI	NaCI	NNP
cord-006860-a3b8hyyr	1076	18	.	.	.
cord-006860-a3b8hyyr	1077	1	AT	at	IN
cord-006860-a3b8hyyr	1077	2	III	III	NNP
cord-006860-a3b8hyyr	1077	3	binds	bind	VBZ
cord-006860-a3b8hyyr	1077	4	more	more	RBR
cord-006860-a3b8hyyr	1077	5	stronger	strong	JJR
cord-006860-a3b8hyyr	1077	6	with	with	IN
cord-006860-a3b8hyyr	1077	7	heparin	heparin	NN
cord-006860-a3b8hyyr	1077	8	-	-	HYPH
cord-006860-a3b8hyyr	1077	9	ceUulose	ceUulose	NNP
cord-006860-a3b8hyyr	1077	10	t[~,~n	t[~,~n	CD
cord-006860-a3b8hyyr	1077	11	with	with	IN
cord-006860-a3b8hyyr	1077	12	silica	silica	NN
cord-006860-a3b8hyyr	1077	13	sorbents	sorbent	NNS
cord-006860-a3b8hyyr	1077	14	but	but	CC
cord-006860-a3b8hyyr	1077	15	specific	specific	JJ
cord-006860-a3b8hyyr	1077	16	activity	activity	NN
cord-006860-a3b8hyyr	1077	17	and	and	CC
cord-006860-a3b8hyyr	1077	18	purity	purity	NN
cord-006860-a3b8hyyr	1077	19	degree	degree	NN
cord-006860-a3b8hyyr	1077	20	were	be	VBD
cord-006860-a3b8hyyr	1077	21	approximately	approximately	RB
cord-006860-a3b8hyyr	1077	22	the	the	DT
cord-006860-a3b8hyyr	1077	23	same	same	JJ
cord-006860-a3b8hyyr	1077	24	on	on	IN
cord-006860-a3b8hyyr	1077	25	both	both	DT
cord-006860-a3b8hyyr	1077	26	kinds	kind	NNS
cord-006860-a3b8hyyr	1077	27	of	of	IN
cord-006860-a3b8hyyr	1077	28	sorbents	sorbent	NNS
cord-006860-a3b8hyyr	1077	29	.	.	.
cord-006860-a3b8hyyr	1078	1	Thrombin	Thrombin	NNP
cord-006860-a3b8hyyr	1078	2	specific	specific	JJ
cord-006860-a3b8hyyr	1078	3	activity	activity	NN
cord-006860-a3b8hyyr	1078	4	and	and	CC
cord-006860-a3b8hyyr	1078	5	purity	purity	NN
cord-006860-a3b8hyyr	1078	6	degree	degree	NN
cord-006860-a3b8hyyr	1078	7	were	be	VBD
cord-006860-a3b8hyyr	1078	8	approximately	approximately	RB
cord-006860-a3b8hyyr	1078	9	twice	twice	RB
cord-006860-a3b8hyyr	1078	10	higher	high	JJR
cord-006860-a3b8hyyr	1078	11	on	on	IN
cord-006860-a3b8hyyr	1078	12	sorbents	sorbent	NNS
cord-006860-a3b8hyyr	1078	13	2	2	CD
cord-006860-a3b8hyyr	1078	14	and	and	CC
cord-006860-a3b8hyyr	1078	15	3	3	CD
cord-006860-a3b8hyyr	1078	16	in	in	IN
cord-006860-a3b8hyyr	1078	17	comparison	comparison	NN
cord-006860-a3b8hyyr	1078	18	with	with	IN
cord-006860-a3b8hyyr	1078	19	sorbents	sorbent	NNS
cord-006860-a3b8hyyr	1078	20	!	!	.
cord-006860-a3b8hyyr	1079	1	and	and	CC
cord-006860-a3b8hyyr	1079	2	4	4	CD
cord-006860-a3b8hyyr	1079	3	(	(	-LRB-
cord-006860-a3b8hyyr	1079	4	2250	2250	CD
cord-006860-a3b8hyyr	1079	5	-	-	SYM
cord-006860-a3b8hyyr	1079	6	3000	3000	CD
cord-006860-a3b8hyyr	1079	7	NIH	NIH	NNP
cord-006860-a3b8hyyr	1079	8	units	unit	NNS
cord-006860-a3b8hyyr	1079	9	/	/	SYM
cord-006860-a3b8hyyr	1079	10	mg	mg	RB
cord-006860-a3b8hyyr	1079	11	versus	versus	IN
cord-006860-a3b8hyyr	1079	12	1260-t350	1260-t350	CD
cord-006860-a3b8hyyr	1079	13	NIH	NIH	NNP
cord-006860-a3b8hyyr	1079	14	unlts	unlts	NNP
cord-006860-a3b8hyyr	1079	15	/	/	SYM
cord-006860-a3b8hyyr	1079	16	mg	mg	NNP
cord-006860-a3b8hyyr	1079	17	)	)	-RRB-
cord-006860-a3b8hyyr	1079	18	.	.	.
cord-006860-a3b8hyyr	1080	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	1080	2	,	,	,
cord-006860-a3b8hyyr	1080	3	sorbents	sorbent	NNS
cord-006860-a3b8hyyr	1080	4	2	2	CD
cord-006860-a3b8hyyr	1080	5	and	and	CC
cord-006860-a3b8hyyr	1080	6	3	3	CD
cord-006860-a3b8hyyr	1080	7	can	can	MD
cord-006860-a3b8hyyr	1080	8	be	be	VB
cord-006860-a3b8hyyr	1080	9	used	use	VBN
cord-006860-a3b8hyyr	1080	10	for	for	IN
cord-006860-a3b8hyyr	1080	11	isolation	isolation	NN
cord-006860-a3b8hyyr	1080	12	and	and	CC
cord-006860-a3b8hyyr	1080	13	purification	purification	NN
cord-006860-a3b8hyyr	1080	14	of	of	IN
cord-006860-a3b8hyyr	1080	15	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1080	16	and	and	CC
cord-006860-a3b8hyyr	1080	17	sorbents	sorbent	NNS
cord-006860-a3b8hyyr	1080	18	t	t	VBP
cord-006860-a3b8hyyr	1080	19	and	and	CC
cord-006860-a3b8hyyr	1080	20	4	4	CD
cord-006860-a3b8hyyr	1080	21	can	can	MD
cord-006860-a3b8hyyr	1080	22	be	be	VB
cord-006860-a3b8hyyr	1080	23	used	use	VBN
cord-006860-a3b8hyyr	1080	24	for	for	IN
cord-006860-a3b8hyyr	1080	25	isolation	isolation	NN
cord-006860-a3b8hyyr	1080	26	and	and	CC
cord-006860-a3b8hyyr	1080	27	puriiication	puriiication	NN
cord-006860-a3b8hyyr	1080	28	of	of	IN
cord-006860-a3b8hyyr	1080	29	AT	AT	NNP
cord-006860-a3b8hyyr	1080	30	II1	II1	NNP
cord-006860-a3b8hyyr	1080	31	.	.	.
cord-006860-a3b8hyyr	1081	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1081	2	used	use	VBD
cord-006860-a3b8hyyr	1081	3	these	these	DT
cord-006860-a3b8hyyr	1081	4	sorbents	sorbent	NNS
cord-006860-a3b8hyyr	1081	5	for	for	IN
cord-006860-a3b8hyyr	1081	6	large	large	JJ
cord-006860-a3b8hyyr	1081	7	scale	scale	NN
cord-006860-a3b8hyyr	1081	8	purification	purification	NN
cord-006860-a3b8hyyr	1081	9	of	of	IN
cord-006860-a3b8hyyr	1081	10	named	name	VBN
cord-006860-a3b8hyyr	1081	11	proteins	protein	NNS
cord-006860-a3b8hyyr	1081	12	.	.	.
cord-006860-a3b8hyyr	1082	1	Purified	purify	VBN
cord-006860-a3b8hyyr	1082	2	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1082	3	was	be	VBD
cord-006860-a3b8hyyr	1082	4	used	use	VBN
cord-006860-a3b8hyyr	1082	5	for	for	IN
cord-006860-a3b8hyyr	1082	6	production	production	NN
cord-006860-a3b8hyyr	1082	7	of	of	IN
cord-006860-a3b8hyyr	1082	8	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	1082	9	kits	kit	NNS
cord-006860-a3b8hyyr	1082	10	for	for	IN
cord-006860-a3b8hyyr	1082	11	anfithrombine	anfithrombine	NNP
cord-006860-a3b8hyyr	1082	12	III	III	NNP
cord-006860-a3b8hyyr	1082	13	,	,	,
cord-006860-a3b8hyyr	1082	14	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1082	15	,	,	,
cord-006860-a3b8hyyr	1082	16	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1082	17	/	/	SYM
cord-006860-a3b8hyyr	1082	18	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1082	19	degradation	degradation	NN
cord-006860-a3b8hyyr	1082	20	products	product	NNS
cord-006860-a3b8hyyr	1082	21	and	and	CC
cord-006860-a3b8hyyr	1082	22	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1082	23	time	time	NN
cord-006860-a3b8hyyr	1082	24	determination	determination	NN
cord-006860-a3b8hyyr	1082	25	.	.	.
cord-006860-a3b8hyyr	1083	1	After	after	IN
cord-006860-a3b8hyyr	1083	2	an	an	DT
cord-006860-a3b8hyyr	1083	3	aerobic	aerobic	JJ
cord-006860-a3b8hyyr	1083	4	or	or	CC
cord-006860-a3b8hyyr	1083	5	anaerobic	anaerobic	JJ
cord-006860-a3b8hyyr	1083	6	physical	physical	JJ
cord-006860-a3b8hyyr	1083	7	exercise	exercise	NN
cord-006860-a3b8hyyr	1083	8	various	various	JJ
cord-006860-a3b8hyyr	1083	9	alterations	alteration	NNS
cord-006860-a3b8hyyr	1083	10	of	of	IN
cord-006860-a3b8hyyr	1083	11	the	the	DT
cord-006860-a3b8hyyr	1083	12	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	1083	13	system	system	NN
cord-006860-a3b8hyyr	1083	14	were	be	VBD
cord-006860-a3b8hyyr	1083	15	detected	detect	VBN
cord-006860-a3b8hyyr	1083	16	.	.	.
cord-006860-a3b8hyyr	1084	1	Numerous	numerous	JJ
cord-006860-a3b8hyyr	1084	2	investigations	investigation	NNS
cord-006860-a3b8hyyr	1084	3	of	of	IN
cord-006860-a3b8hyyr	1084	4	the	the	DT
cord-006860-a3b8hyyr	1084	5	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	1084	6	system	system	NN
cord-006860-a3b8hyyr	1084	7	exist	exist	VBP
cord-006860-a3b8hyyr	1084	8	of	of	IN
cord-006860-a3b8hyyr	1084	9	running	run	VBG
cord-006860-a3b8hyyr	1084	10	and	and	CC
cord-006860-a3b8hyyr	1084	11	of	of	IN
cord-006860-a3b8hyyr	1084	12	bicycle	bicycle	NN
cord-006860-a3b8hyyr	1084	13	ergometer	ergometer	NN
cord-006860-a3b8hyyr	1084	14	exercise	exercise	NN
cord-006860-a3b8hyyr	1084	15	but	but	CC
cord-006860-a3b8hyyr	1084	16	not	not	RB
cord-006860-a3b8hyyr	1084	17	of	of	IN
cord-006860-a3b8hyyr	1084	18	swimming	swim	VBG
cord-006860-a3b8hyyr	1084	19	.	.	.
cord-006860-a3b8hyyr	1085	1	Young	young	JJ
cord-006860-a3b8hyyr	1085	2	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	1085	3	(	(	-LRB-
cord-006860-a3b8hyyr	1085	4	n=54	n=54	JJ
cord-006860-a3b8hyyr	1085	5	;	;	:
cord-006860-a3b8hyyr	1085	6	median	median	JJ
cord-006860-a3b8hyyr	1085	7	age	age	NN
cord-006860-a3b8hyyr	1085	8	25	25	CD
cord-006860-a3b8hyyr	1085	9	years	year	NNS
cord-006860-a3b8hyyr	1085	10	)	)	-RRB-
cord-006860-a3b8hyyr	1085	11	were	be	VBD
cord-006860-a3b8hyyr	1085	12	investigeted~	investigeted~	NNP
cord-006860-a3b8hyyr	1086	1	There	there	EX
cord-006860-a3b8hyyr	1086	2	was	be	VBD
cord-006860-a3b8hyyr	1086	3	an	an	DT
cord-006860-a3b8hyyr	1086	4	aerobic	aerobic	JJ
cord-006860-a3b8hyyr	1086	5	exercise	exercise	NN
cord-006860-a3b8hyyr	1086	6	(	(	-LRB-
cord-006860-a3b8hyyr	1086	7	achieved	achieve	VBN
cord-006860-a3b8hyyr	1086	8	heart	heart	NN
cord-006860-a3b8hyyr	1086	9	rate	rate	NN
cord-006860-a3b8hyyr	1086	10	130	130	CD
cord-006860-a3b8hyyr	1086	11	--10	--10	NNP
cord-006860-a3b8hyyr	1086	12	/	/	SYM
cord-006860-a3b8hyyr	1086	13	min	min	NN
cord-006860-a3b8hyyr	1086	14	,	,	,
cord-006860-a3b8hyyr	1086	15	lactate	lactate	NN
cord-006860-a3b8hyyr	1086	16	<	<	XX
cord-006860-a3b8hyyr	1086	17	4	4	CD
cord-006860-a3b8hyyr	1086	18	mmol	mmol	VBN
cord-006860-a3b8hyyr	1086	19	;	;	:
cord-006860-a3b8hyyr	1086	20	n=	n=	NNP
cord-006860-a3b8hyyr	1086	21	27	27	CD
cord-006860-a3b8hyyr	1086	22	)	)	-RRB-
cord-006860-a3b8hyyr	1086	23	and	and	CC
cord-006860-a3b8hyyr	1086	24	an	an	DT
cord-006860-a3b8hyyr	1086	25	anaerobic	anaerobic	JJ
cord-006860-a3b8hyyr	1086	26	exercise	exercise	NN
cord-006860-a3b8hyyr	1086	27	(	(	-LRB-
cord-006860-a3b8hyyr	1086	28	achieved	achieve	VBN
cord-006860-a3b8hyyr	1086	29	heart	heart	NN
cord-006860-a3b8hyyr	1086	30	rate	rate	NN
cord-006860-a3b8hyyr	1086	31	150	150	CD
cord-006860-a3b8hyyr	1086	32	~	~	NFP
cord-006860-a3b8hyyr	1086	33	lO	lO	NNP
cord-006860-a3b8hyyr	1086	34	/	/	SYM
cord-006860-a3b8hyyr	1086	35	min	min	NN
cord-006860-a3b8hyyr	1086	36	,	,	,
cord-006860-a3b8hyyr	1086	37	lactate	lactate	NN
cord-006860-a3b8hyyr	1086	38	>	>	XX
cord-006860-a3b8hyyr	1086	39	4	4	CD
cord-006860-a3b8hyyr	1086	40	mmol/1	mmol/1	NN
cord-006860-a3b8hyyr	1086	41	;	;	:
cord-006860-a3b8hyyr	1086	42	n=	n=	NNP
cord-006860-a3b8hyyr	1086	43	27	27	CD
cord-006860-a3b8hyyr	1086	44	)	)	-RRB-
cord-006860-a3b8hyyr	1086	45	.	.	.
cord-006860-a3b8hyyr	1087	1	In	in	IN
cord-006860-a3b8hyyr	1087	2	both	both	DT
cord-006860-a3b8hyyr	1087	3	groups	group	NNS
cord-006860-a3b8hyyr	1087	4	there	there	EX
cord-006860-a3b8hyyr	1087	5	was	be	VBD
cord-006860-a3b8hyyr	1087	6	a	a	DT
cord-006860-a3b8hyyr	1087	7	significant	significant	JJ
cord-006860-a3b8hyyr	1087	8	shortening	shortening	NN
cord-006860-a3b8hyyr	1087	9	of	of	IN
cord-006860-a3b8hyyr	1087	10	the	the	DT
cord-006860-a3b8hyyr	1087	11	PTT	PTT	NNP
cord-006860-a3b8hyyr	1087	12	.	.	.
cord-006860-a3b8hyyr	1088	1	Under	under	IN
cord-006860-a3b8hyyr	1088	2	anaerobic	anaerobic	JJ
cord-006860-a3b8hyyr	1088	3	conditions	condition	NNS
cord-006860-a3b8hyyr	1088	4	hematocrit	hematocrit	NN
cord-006860-a3b8hyyr	1088	5	and	and	CC
cord-006860-a3b8hyyr	1088	6	quick	quick	JJ
cord-006860-a3b8hyyr	1088	7	significantly	significantly	RB
cord-006860-a3b8hyyr	1088	8	increased	increase	VBN
cord-006860-a3b8hyyr	1088	9	.	.	.
cord-006860-a3b8hyyr	1089	1	Factor	factor	NN
cord-006860-a3b8hyyr	1089	2	VIII	VIII	NNP
cord-006860-a3b8hyyr	1089	3	activity	activity	NN
cord-006860-a3b8hyyr	1089	4	rose	rise	VBD
cord-006860-a3b8hyyr	1089	5	significantly	significantly	RB
cord-006860-a3b8hyyr	1089	6	in	in	IN
cord-006860-a3b8hyyr	1089	7	both	both	DT
cord-006860-a3b8hyyr	1089	8	groups	group	NNS
cord-006860-a3b8hyyr	1089	9	.	.	.
cord-006860-a3b8hyyr	1090	1	Indicating	indicate	VBG
cord-006860-a3b8hyyr	1090	2	plasmatic	plasmatic	JJ
cord-006860-a3b8hyyr	1090	3	clotting	clotting	NN
cord-006860-a3b8hyyr	1090	4	activation	activation	NN
cord-006860-a3b8hyyr	1090	5	there	there	EX
cord-006860-a3b8hyyr	1090	6	was	be	VBD
cord-006860-a3b8hyyr	1090	7	a	a	DT
cord-006860-a3b8hyyr	1090	8	significant	significant	JJ
cord-006860-a3b8hyyr	1090	9	increase	increase	NN
cord-006860-a3b8hyyr	1090	10	in	in	IN
cord-006860-a3b8hyyr	1090	11	molecular	molecular	JJ
cord-006860-a3b8hyyr	1090	12	markers	marker	NNS
cord-006860-a3b8hyyr	1090	13	TAT	tat	NN
cord-006860-a3b8hyyr	1090	14	and	and	CC
cord-006860-a3b8hyyr	1090	15	F1	f1	NN
cord-006860-a3b8hyyr	1091	1	+2	+2	NFP
cord-006860-a3b8hyyr	1091	2	only	only	RB
cord-006860-a3b8hyyr	1091	3	under	under	IN
cord-006860-a3b8hyyr	1091	4	anaerobic	anaerobic	JJ
cord-006860-a3b8hyyr	1091	5	conditions	condition	NNS
cord-006860-a3b8hyyr	1091	6	(	(	-LRB-
cord-006860-a3b8hyyr	1091	7	TAT	tat	NN
cord-006860-a3b8hyyr	1091	8	from	from	IN
cord-006860-a3b8hyyr	1091	9	2,5	2,5	CD
cord-006860-a3b8hyyr	1091	10	to	to	IN
cord-006860-a3b8hyyr	1091	11	5,4	5,4	CD
cord-006860-a3b8hyyr	1091	12	pg/1	pg/1	NN
cord-006860-a3b8hyyr	1091	13	;	;	.
cord-006860-a3b8hyyr	1092	1	F1	f1	NN
cord-006860-a3b8hyyr	1092	2	+	+	SYM
cord-006860-a3b8hyyr	1092	3	2	2	CD
cord-006860-a3b8hyyr	1092	4	from	from	IN
cord-006860-a3b8hyyr	1092	5	0,87	0,87	CD
cord-006860-a3b8hyyr	1092	6	to	to	IN
cord-006860-a3b8hyyr	1092	7	0,93	0,93	CD
cord-006860-a3b8hyyr	1093	1	nmol/1	nmol/1	NNP
cord-006860-a3b8hyyr	1093	2	)	)	-RRB-
cord-006860-a3b8hyyr	1093	3	.	.	.
cord-006860-a3b8hyyr	1094	1	Indicating	indicate	VBG
cord-006860-a3b8hyyr	1094	2	activation	activation	NN
cord-006860-a3b8hyyr	1094	3	of	of	IN
cord-006860-a3b8hyyr	1094	4	fibrinolysis	fibrinolysis	NNP
cord-006860-a3b8hyyr	1094	5	t	t	NNP
cord-006860-a3b8hyyr	1094	6	-	-	HYPH
cord-006860-a3b8hyyr	1094	7	PA	PA	NNP
cord-006860-a3b8hyyr	1094	8	activity	activity	NN
cord-006860-a3b8hyyr	1094	9	increased	increase	VBD
cord-006860-a3b8hyyr	1094	10	significantly	significantly	RB
cord-006860-a3b8hyyr	1094	11	in	in	IN
cord-006860-a3b8hyyr	1094	12	the	the	DT
cord-006860-a3b8hyyr	1094	13	anaerobic	anaerobic	JJ
cord-006860-a3b8hyyr	1094	14	group	group	NN
cord-006860-a3b8hyyr	1094	15	(	(	-LRB-
cord-006860-a3b8hyyr	1094	16	from	from	IN
cord-006860-a3b8hyyr	1094	17	0,1	0,1	CD
cord-006860-a3b8hyyr	1094	18	to	to	IN
cord-006860-a3b8hyyr	1094	19	0,4	0,4	CD
cord-006860-a3b8hyyr	1094	20	IU	IU	NNP
cord-006860-a3b8hyyr	1094	21	/	/	SYM
cord-006860-a3b8hyyr	1094	22	ml	ml	NN
cord-006860-a3b8hyyr	1094	23	)	)	-RRB-
cord-006860-a3b8hyyr	1094	24	but	but	CC
cord-006860-a3b8hyyr	1094	25	not	not	RB
cord-006860-a3b8hyyr	1094	26	in	in	IN
cord-006860-a3b8hyyr	1094	27	the	the	DT
cord-006860-a3b8hyyr	1094	28	other	other	JJ
cord-006860-a3b8hyyr	1094	29	group	group	NN
cord-006860-a3b8hyyr	1094	30	.	.	.
cord-006860-a3b8hyyr	1095	1	This	this	DT
cord-006860-a3b8hyyr	1095	2	findings	finding	NNS
cord-006860-a3b8hyyr	1095	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	1095	4	that	that	IN
cord-006860-a3b8hyyr	1095	5	there	there	EX
cord-006860-a3b8hyyr	1095	6	is	be	VBZ
cord-006860-a3b8hyyr	1095	7	e	e	DT
cord-006860-a3b8hyyr	1095	8	balance	balance	NN
cord-006860-a3b8hyyr	1095	9	in	in	IN
cord-006860-a3b8hyyr	1095	10	the	the	DT
cord-006860-a3b8hyyr	1095	11	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	1095	12	system	system	NN
cord-006860-a3b8hyyr	1095	13	by	by	IN
cord-006860-a3b8hyyr	1095	14	activation	activation	NN
cord-006860-a3b8hyyr	1095	15	of	of	IN
cord-006860-a3b8hyyr	1095	16	clotting	clotting	NN
cord-006860-a3b8hyyr	1095	17	as	as	RB
cord-006860-a3b8hyyr	1095	18	well	well	RB
cord-006860-a3b8hyyr	1095	19	as	as	IN
cord-006860-a3b8hyyr	1095	20	of	of	IN
cord-006860-a3b8hyyr	1095	21	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1095	22	system	system	NN
cord-006860-a3b8hyyr	1095	23	in	in	IN
cord-006860-a3b8hyyr	1095	24	young	young	JJ
cord-006860-a3b8hyyr	1095	25	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	1095	26	during	during	IN
cord-006860-a3b8hyyr	1095	27	exercise	exercise	NN
cord-006860-a3b8hyyr	1095	28	by	by	IN
cord-006860-a3b8hyyr	1095	29	swimming	swim	VBG
cord-006860-a3b8hyyr	1095	30	dependend	dependend	NN
cord-006860-a3b8hyyr	1095	31	on	on	IN
cord-006860-a3b8hyyr	1095	32	the	the	DT
cord-006860-a3b8hyyr	1095	33	degree	degree	NN
cord-006860-a3b8hyyr	1095	34	of	of	IN
cord-006860-a3b8hyyr	1095	35	exercise	exercise	NN
cord-006860-a3b8hyyr	1095	36	load	load	NN
cord-006860-a3b8hyyr	1095	37	.	.	.
cord-006860-a3b8hyyr	1096	1	Membranes	membrane	NNS
cord-006860-a3b8hyyr	1096	2	as	as	RB
cord-006860-a3b8hyyr	1096	3	well	well	RB
cord-006860-a3b8hyyr	1096	4	as	as	IN
cord-006860-a3b8hyyr	1096	5	compact	compact	JJ
cord-006860-a3b8hyyr	1096	6	,	,	,
cord-006860-a3b8hyyr	1096	7	porous	porous	JJ
cord-006860-a3b8hyyr	1096	8	disks	disk	NNS
cord-006860-a3b8hyyr	1096	9	are	be	VBP
cord-006860-a3b8hyyr	1096	10	successfully	successfully	RB
cord-006860-a3b8hyyr	1096	11	used	use	VBN
cord-006860-a3b8hyyr	1096	12	for	for	IN
cord-006860-a3b8hyyr	1096	13	fast	fast	JJ
cord-006860-a3b8hyyr	1096	14	analytical	analytical	JJ
cord-006860-a3b8hyyr	1096	15	separations	separation	NNS
cord-006860-a3b8hyyr	1096	16	of	of	IN
cord-006860-a3b8hyyr	1096	17	biopolymers	biopolymer	NNS
cord-006860-a3b8hyyr	1096	18	.	.	.
cord-006860-a3b8hyyr	1097	1	As	as	RB
cord-006860-a3b8hyyr	1097	2	far	far	RB
cord-006860-a3b8hyyr	1097	3	as	as	IN
cord-006860-a3b8hyyr	1097	4	capacity	capacity	NN
cord-006860-a3b8hyyr	1097	5	,	,	,
cord-006860-a3b8hyyr	1097	6	speed	speed	NN
cord-006860-a3b8hyyr	1097	7	and	and	CC
cord-006860-a3b8hyyr	1097	8	performance	performance	NN
cord-006860-a3b8hyyr	1097	9	of	of	IN
cord-006860-a3b8hyyr	1097	10	separation	separation	NN
cord-006860-a3b8hyyr	1097	11	are	be	VBP
cord-006860-a3b8hyyr	1097	12	concerned	concern	VBN
cord-006860-a3b8hyyr	1097	13	,	,	,
cord-006860-a3b8hyyr	1097	14	the	the	DT
cord-006860-a3b8hyyr	1097	15	supports	support	NNS
cord-006860-a3b8hyyr	1097	16	are	be	VBP
cord-006860-a3b8hyyr	1097	17	as	as	RB
cord-006860-a3b8hyyr	1097	18	effective	effective	JJ
cord-006860-a3b8hyyr	1097	19	as	as	IN
cord-006860-a3b8hyyr	1097	20	other	other	JJ
cord-006860-a3b8hyyr	1097	21	recently	recently	RB
cord-006860-a3b8hyyr	1097	22	developed	develop	VBN
cord-006860-a3b8hyyr	1097	23	fast	fast	JJ
cord-006860-a3b8hyyr	1097	24	media	medium	NNS
cord-006860-a3b8hyyr	1097	25	for	for	IN
cord-006860-a3b8hyyr	1097	26	the	the	DT
cord-006860-a3b8hyyr	1097	27	separation	separation	NN
cord-006860-a3b8hyyr	1097	28	of	of	IN
cord-006860-a3b8hyyr	1097	29	biopolymers	biopolymer	NNS
cord-006860-a3b8hyyr	1097	30	°	°	NNP
cord-006860-a3b8hyyr	1097	31	)	)	-RRB-
cord-006860-a3b8hyyr	1097	32	.	.	.
cord-006860-a3b8hyyr	1098	1	So	so	RB
cord-006860-a3b8hyyr	1098	2	far	far	RB
cord-006860-a3b8hyyr	1098	3	,	,	,
cord-006860-a3b8hyyr	1098	4	technical	technical	JJ
cord-006860-a3b8hyyr	1098	5	difficulties	difficulty	NNS
cord-006860-a3b8hyyr	1098	6	have	have	VBP
cord-006860-a3b8hyyr	1098	7	prevented	prevent	VBN
cord-006860-a3b8hyyr	1098	8	the	the	DT
cord-006860-a3b8hyyr	1098	9	proper	proper	JJ
cord-006860-a3b8hyyr	1098	10	scaling	scaling	NN
cord-006860-a3b8hyyr	1098	11	-	-	HYPH
cord-006860-a3b8hyyr	1098	12	up	up	NN
cord-006860-a3b8hyyr	1098	13	of	of	IN
cord-006860-a3b8hyyr	1098	14	the	the	DT
cord-006860-a3b8hyyr	1098	15	processes	process	NNS
cord-006860-a3b8hyyr	1098	16	and	and	CC
cord-006860-a3b8hyyr	1098	17	the	the	DT
cord-006860-a3b8hyyr	1098	18	use	use	NN
cord-006860-a3b8hyyr	1098	19	of	of	IN
cord-006860-a3b8hyyr	1098	20	membranes	membrane	NNS
cord-006860-a3b8hyyr	1098	21	and	and	CC
cord-006860-a3b8hyyr	1098	22	compact	compact	JJ
cord-006860-a3b8hyyr	1098	23	disks	disk	NNS
cord-006860-a3b8hyyr	1098	24	for	for	IN
cord-006860-a3b8hyyr	1098	25	preparative	preparative	JJ
cord-006860-a3b8hyyr	1098	26	separations	separation	NNS
cord-006860-a3b8hyyr	1098	27	.	.	.
cord-006860-a3b8hyyr	1099	1	In	in	IN
cord-006860-a3b8hyyr	1099	2	this	this	DT
cord-006860-a3b8hyyr	1099	3	report	report	NN
cord-006860-a3b8hyyr	1099	4	,	,	,
cord-006860-a3b8hyyr	1099	5	the	the	DT
cord-006860-a3b8hyyr	1099	6	use	use	NN
cord-006860-a3b8hyyr	1099	7	of	of	IN
cord-006860-a3b8hyyr	1099	8	a	a	DT
cord-006860-a3b8hyyr	1099	9	compact	compact	JJ
cord-006860-a3b8hyyr	1099	10	tube	tube	NN
cord-006860-a3b8hyyr	1099	11	made	make	VBN
cord-006860-a3b8hyyr	1099	12	of	of	IN
cord-006860-a3b8hyyr	1099	13	poly(glycidyl	poly(glycidyl	JJ
cord-006860-a3b8hyyr	1099	14	methacrylate	methacrylate	NN
cord-006860-a3b8hyyr	1099	15	)	)	-RRB-
cord-006860-a3b8hyyr	1099	16	for	for	IN
cord-006860-a3b8hyyr	1099	17	fast	fast	JJ
cord-006860-a3b8hyyr	1099	18	preparative	preparative	JJ
cord-006860-a3b8hyyr	1099	19	separations	separation	NNS
cord-006860-a3b8hyyr	1099	20	of	of	IN
cord-006860-a3b8hyyr	1099	21	proteins	protein	NNS
cord-006860-a3b8hyyr	1099	22	is	be	VBZ
cord-006860-a3b8hyyr	1099	23	shown	show	VBN
cord-006860-a3b8hyyr	1099	24	as	as	IN
cord-006860-a3b8hyyr	1099	25	a	a	DT
cord-006860-a3b8hyyr	1099	26	possible	possible	JJ
cord-006860-a3b8hyyr	1099	27	solution	solution	NN
cord-006860-a3b8hyyr	1099	28	of	of	IN
cord-006860-a3b8hyyr	1099	29	these	these	DT
cord-006860-a3b8hyyr	1099	30	problems	problem	NNS
cord-006860-a3b8hyyr	1099	31	.	.	.
cord-006860-a3b8hyyr	1100	1	The	the	DT
cord-006860-a3b8hyyr	1100	2	units	unit	NNS
cord-006860-a3b8hyyr	1100	3	have	have	VBP
cord-006860-a3b8hyyr	1100	4	yielded	yield	VBN
cord-006860-a3b8hyyr	1100	5	excellent	excellent	JJ
cord-006860-a3b8hyyr	1100	6	results	result	NNS
cord-006860-a3b8hyyr	1100	7	,	,	,
cord-006860-a3b8hyyr	1100	8	regarding	regard	VBG
cord-006860-a3b8hyyr	1100	9	performance	performance	NN
cord-006860-a3b8hyyr	1100	10	and	and	CC
cord-006860-a3b8hyyr	1100	11	speed	speed	NN
cord-006860-a3b8hyyr	1100	12	of	of	IN
cord-006860-a3b8hyyr	1100	13	separation	separation	NN
cord-006860-a3b8hyyr	1100	14	as	as	RB
cord-006860-a3b8hyyr	1100	15	well	well	RB
cord-006860-a3b8hyyr	1100	16	as	as	IN
cord-006860-a3b8hyyr	1100	17	capacity	capacity	NN
cord-006860-a3b8hyyr	1100	18	.	.	.
cord-006860-a3b8hyyr	1101	1	The	the	DT
cord-006860-a3b8hyyr	1101	2	application	application	NN
cord-006860-a3b8hyyr	1101	3	of	of	IN
cord-006860-a3b8hyyr	1101	4	compact	compact	JJ
cord-006860-a3b8hyyr	1101	5	tubes	tube	NNS
cord-006860-a3b8hyyr	1101	6	made	make	VBN
cord-006860-a3b8hyyr	1101	7	of	of	IN
cord-006860-a3b8hyyr	1101	8	poly(glycidyl	poly(glycidyl	JJ
cord-006860-a3b8hyyr	1101	9	methacrylate	methacrylate	NN
cord-006860-a3b8hyyr	1101	10	)	)	-RRB-
cord-006860-a3b8hyyr	1101	11	for	for	IN
cord-006860-a3b8hyyr	1101	12	the	the	DT
cord-006860-a3b8hyyr	1101	13	preparative	preparative	JJ
cord-006860-a3b8hyyr	1101	14	isolation	isolation	NN
cord-006860-a3b8hyyr	1101	15	of	of	IN
cord-006860-a3b8hyyr	1101	16	the	the	DT
cord-006860-a3b8hyyr	1101	17	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1101	18	factors	factor	NNS
cord-006860-a3b8hyyr	1101	19	VIII	VIII	NNP
cord-006860-a3b8hyyr	1101	20	and	and	CC
cord-006860-a3b8hyyr	1101	21	IX	IX	NNP
cord-006860-a3b8hyyr	1101	22	from	from	IN
cord-006860-a3b8hyyr	1101	23	human	human	JJ
cord-006860-a3b8hyyr	1101	24	plasma	plasma	NN
cord-006860-a3b8hyyr	1101	25	shows	show	VBZ
cord-006860-a3b8hyyr	1101	26	that	that	IN
cord-006860-a3b8hyyr	1101	27	this	this	DT
cord-006860-a3b8hyyr	1101	28	method	method	NN
cord-006860-a3b8hyyr	1101	29	can	can	MD
cord-006860-a3b8hyyr	1101	30	even	even	RB
cord-006860-a3b8hyyr	1101	31	be	be	VB
cord-006860-a3b8hyyr	1101	32	used	use	VBN
cord-006860-a3b8hyyr	1101	33	for	for	IN
cord-006860-a3b8hyyr	1101	34	the	the	DT
cord-006860-a3b8hyyr	1101	35	separation	separation	NN
cord-006860-a3b8hyyr	1101	36	of	of	IN
cord-006860-a3b8hyyr	1101	37	very	very	RB
cord-006860-a3b8hyyr	1101	38	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	1101	39	biopolymers	biopolymer	NNS
cord-006860-a3b8hyyr	1101	40	.	.	.
cord-006860-a3b8hyyr	1102	1	In	in	IN
cord-006860-a3b8hyyr	1102	2	terms	term	NNS
cord-006860-a3b8hyyr	1102	3	of	of	IN
cord-006860-a3b8hyyr	1102	4	yield	yield	NN
cord-006860-a3b8hyyr	1102	5	and	and	CC
cord-006860-a3b8hyyr	1102	6	purity	purity	NN
cord-006860-a3b8hyyr	1102	7	of	of	IN
cord-006860-a3b8hyyr	1102	8	the	the	DT
cord-006860-a3b8hyyr	1102	9	isolated	isolate	VBN
cord-006860-a3b8hyyr	1102	10	proteins	protein	NNS
cord-006860-a3b8hyyr	1102	11	,	,	,
cord-006860-a3b8hyyr	1102	12	this	this	DT
cord-006860-a3b8hyyr	1102	13	method	method	NN
cord-006860-a3b8hyyr	1102	14	was	be	VBD
cord-006860-a3b8hyyr	1102	15	comparable	comparable	JJ
cord-006860-a3b8hyyr	1102	16	to	to	IN
cord-006860-a3b8hyyr	1102	17	preparative	preparative	JJ
cord-006860-a3b8hyyr	1102	18	column	column	NN
cord-006860-a3b8hyyr	1102	19	chromatography	chromatography	NN
cord-006860-a3b8hyyr	1102	20	.	.	.
cord-006860-a3b8hyyr	1103	1	The	the	DT
cord-006860-a3b8hyyr	1103	2	period	period	NN
cord-006860-a3b8hyyr	1103	3	of	of	IN
cord-006860-a3b8hyyr	1103	4	time	time	NN
cord-006860-a3b8hyyr	1103	5	required	require	VBN
cord-006860-a3b8hyyr	1103	6	for	for	IN
cord-006860-a3b8hyyr	1103	7	separation	separation	NN
cord-006860-a3b8hyyr	1103	8	was	be	VBD
cord-006860-a3b8hyyr	1103	9	five	five	CD
cord-006860-a3b8hyyr	1103	10	times	time	NNS
cord-006860-a3b8hyyr	1103	11	shorter	short	JJR
cord-006860-a3b8hyyr	1103	12	than	than	IN
cord-006860-a3b8hyyr	1103	13	with	with	IN
cord-006860-a3b8hyyr	1103	14	corresponding	corresponding	JJ
cord-006860-a3b8hyyr	1103	15	column	column	NN
cord-006860-a3b8hyyr	1103	16	chromatographical	chromatographical	JJ
cord-006860-a3b8hyyr	1103	17	methods	method	NNS
cord-006860-a3b8hyyr	1103	18	.	.	.
cord-006860-a3b8hyyr	1104	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	1104	2	measurements	measurement	NNS
cord-006860-a3b8hyyr	1104	3	showed	show	VBD
cord-006860-a3b8hyyr	1104	4	an	an	DT
cord-006860-a3b8hyyr	1104	5	excellent	excellent	JJ
cord-006860-a3b8hyyr	1104	6	correlation	correlation	NN
cord-006860-a3b8hyyr	1104	7	of	of	IN
cord-006860-a3b8hyyr	1104	8	the	the	DT
cord-006860-a3b8hyyr	1104	9	two	two	CD
cord-006860-a3b8hyyr	1104	10	systems	system	NNS
cord-006860-a3b8hyyr	1104	11	(	(	-LRB-
cord-006860-a3b8hyyr	1104	12	r=0,99	r=0,99	NNP
cord-006860-a3b8hyyr	1104	13	)	)	-RRB-
cord-006860-a3b8hyyr	1104	14	.	.	.
cord-006860-a3b8hyyr	1105	1	The	the	DT
cord-006860-a3b8hyyr	1105	2	maximum	maximum	JJ
cord-006860-a3b8hyyr	1105	3	amplitudes	amplitude	NNS
cord-006860-a3b8hyyr	1105	4	on	on	IN
cord-006860-a3b8hyyr	1105	5	the	the	DT
cord-006860-a3b8hyyr	1105	6	roTEG	roteg	NN
cord-006860-a3b8hyyr	1105	7	were	be	VBD
cord-006860-a3b8hyyr	1105	8	on	on	IN
cord-006860-a3b8hyyr	1105	9	average	average	JJ
cord-006860-a3b8hyyr	1105	10	2.2	2.2	CD
cord-006860-a3b8hyyr	1105	11	%	%	NN
cord-006860-a3b8hyyr	1105	12	higher	high	JJR
cord-006860-a3b8hyyr	1105	13	than	than	IN
cord-006860-a3b8hyyr	1105	14	on	on	IN
cord-006860-a3b8hyyr	1105	15	the	the	DT
cord-006860-a3b8hyyr	1105	16	HTEG	HTEG	NNP
cord-006860-a3b8hyyr	1105	17	,	,	,
cord-006860-a3b8hyyr	1105	18	corresponding	correspond	VBG
cord-006860-a3b8hyyr	1105	19	to	to	IN
cord-006860-a3b8hyyr	1105	20	a	a	DT
cord-006860-a3b8hyyr	1105	21	slightly	slightly	RB
cord-006860-a3b8hyyr	1105	22	lower	low	JJR
cord-006860-a3b8hyyr	1105	23	reverse	reverse	JJ
cord-006860-a3b8hyyr	1105	24	momentum	momentum	NN
cord-006860-a3b8hyyr	1105	25	of	of	IN
cord-006860-a3b8hyyr	1105	26	the	the	DT
cord-006860-a3b8hyyr	1105	27	measuring	measure	VBG
cord-006860-a3b8hyyr	1105	28	system	system	NN
cord-006860-a3b8hyyr	1105	29	in	in	IN
cord-006860-a3b8hyyr	1105	30	comparison	comparison	NN
cord-006860-a3b8hyyr	1105	31	to	to	IN
cord-006860-a3b8hyyr	1105	32	the	the	DT
cord-006860-a3b8hyyr	1105	33	HTEG	HTEG	NNP
cord-006860-a3b8hyyr	1105	34	.	.	.
cord-006860-a3b8hyyr	1106	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1106	2	report	report	VBP
cord-006860-a3b8hyyr	1106	3	first	first	JJ
cord-006860-a3b8hyyr	1106	4	results	result	NNS
cord-006860-a3b8hyyr	1106	5	out	out	IN
cord-006860-a3b8hyyr	1106	6	of	of	IN
cord-006860-a3b8hyyr	1106	7	the	the	DT
cord-006860-a3b8hyyr	1106	8	evaluation	evaluation	NN
cord-006860-a3b8hyyr	1106	9	of	of	IN
cord-006860-a3b8hyyr	1106	10	STA	STA	NNP
cord-006860-a3b8hyyr	1106	11	Compact	Compact	NNP
cord-006860-a3b8hyyr	1106	12	(	(	-LRB-
cord-006860-a3b8hyyr	1106	13	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	1106	14	Mannheim	Mannheim	NNP
cord-006860-a3b8hyyr	1106	15	/	/	SYM
cord-006860-a3b8hyyr	1106	16	Diagnostica	Diagnostica	NNP
cord-006860-a3b8hyyr	1106	17	STACK	STACK	NNP
cord-006860-a3b8hyyr	1106	18	)	)	-RRB-
cord-006860-a3b8hyyr	1106	19	)	)	-RRB-
cord-006860-a3b8hyyr	1106	20	.	.	.
cord-006860-a3b8hyyr	1107	1	STA	STA	NNP
cord-006860-a3b8hyyr	1107	2	Compact	Compact	NNP
cord-006860-a3b8hyyr	1107	3	is	be	VBZ
cord-006860-a3b8hyyr	1107	4	designed	design	VBN
cord-006860-a3b8hyyr	1107	5	for	for	IN
cord-006860-a3b8hyyr	1107	6	automated	automate	VBN
cord-006860-a3b8hyyr	1107	7	analyses	analysis	NNS
cord-006860-a3b8hyyr	1107	8	of	of	IN
cord-006860-a3b8hyyr	1107	9	routine	routine	JJ
cord-006860-a3b8hyyr	1107	10	and	and	CC
cord-006860-a3b8hyyr	1107	11	special	special	JJ
cord-006860-a3b8hyyr	1107	12	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1107	13	(	(	-LRB-
cord-006860-a3b8hyyr	1107	14	chronometfic	chronometfic	NNP
cord-006860-a3b8hyyr	1107	15	,	,	,
cord-006860-a3b8hyyr	1107	16	photometric	photometric	JJ
cord-006860-a3b8hyyr	1107	17	[	[	-LRB-
cord-006860-a3b8hyyr	1107	18	405	405	CD
cord-006860-a3b8hyyr	1107	19	nm	nm	NN
cord-006860-a3b8hyyr	1107	20	]	]	-RRB-
cord-006860-a3b8hyyr	1107	21	and	and	CC
cord-006860-a3b8hyyr	1107	22	turbidimetric	turbidimetric	JJ
cord-006860-a3b8hyyr	1107	23	[	[	-LRB-
cord-006860-a3b8hyyr	1107	24	540	540	CD
cord-006860-a3b8hyyr	1107	25	run	run	NN
cord-006860-a3b8hyyr	1107	26	]	]	-RRB-
cord-006860-a3b8hyyr	1107	27	)	)	-RRB-
cord-006860-a3b8hyyr	1107	28	tests	test	NNS
cord-006860-a3b8hyyr	1107	29	.	.	.
cord-006860-a3b8hyyr	1108	1	In	in	IN
cord-006860-a3b8hyyr	1108	2	addition	addition	NN
cord-006860-a3b8hyyr	1108	3	,	,	,
cord-006860-a3b8hyyr	1108	4	it	-PRON-	PRP
cord-006860-a3b8hyyr	1108	5	does	do	VBZ
cord-006860-a3b8hyyr	1108	6	measure	measure	NN
cord-006860-a3b8hyyr	1108	7	,	,	,
cord-006860-a3b8hyyr	1108	8	,	,	,
cord-006860-a3b8hyyr	1108	9	derived	derive	VBN
cord-006860-a3b8hyyr	1108	10	"	"	``
cord-006860-a3b8hyyr	1108	11	fihrinogen	fihrinogen	NN
cord-006860-a3b8hyyr	1108	12	.	.	.
cord-006860-a3b8hyyr	1109	1	Tests	test	NNS
cord-006860-a3b8hyyr	1109	2	as	as	IN
cord-006860-a3b8hyyr	1109	3	follows	follow	VBZ
cord-006860-a3b8hyyr	1109	4	were	be	VBD
cord-006860-a3b8hyyr	1109	5	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	1109	6	:	:	:
cord-006860-a3b8hyyr	1109	7	Prothrombin	Prothrombin	NNP
cord-006860-a3b8hyyr	1109	8	time	time	NN
cord-006860-a3b8hyyr	1109	9	(	(	-LRB-
cord-006860-a3b8hyyr	1109	10	PT	PT	NNP
cord-006860-a3b8hyyr	1109	11	)	)	-RRB-
cord-006860-a3b8hyyr	1109	12	,	,	,
cord-006860-a3b8hyyr	1109	13	partial	partial	JJ
cord-006860-a3b8hyyr	1109	14	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	1109	15	time	time	NN
cord-006860-a3b8hyyr	1109	16	(	(	-LRB-
cord-006860-a3b8hyyr	1109	17	aPTT	aptt	NN
cord-006860-a3b8hyyr	1109	18	)	)	-RRB-
cord-006860-a3b8hyyr	1109	19	,	,	,
cord-006860-a3b8hyyr	1109	20	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1109	21	(	(	-LRB-
cord-006860-a3b8hyyr	1109	22	Clauss	Clauss	NNP
cord-006860-a3b8hyyr	1109	23	method	method	NN
cord-006860-a3b8hyyr	1109	24	)	)	-RRB-
cord-006860-a3b8hyyr	1109	25	,	,	,
cord-006860-a3b8hyyr	1109	26	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1109	27	time	time	NN
cord-006860-a3b8hyyr	1109	28	,	,	,
cord-006860-a3b8hyyr	1109	29	AT	at	IN
cord-006860-a3b8hyyr	1109	30	III	III	NNP
cord-006860-a3b8hyyr	1109	31	(	(	-LRB-
cord-006860-a3b8hyyr	1109	32	chromogen	chromogen	NNP
cord-006860-a3b8hyyr	1109	33	)	)	-RRB-
cord-006860-a3b8hyyr	1109	34	,	,	,
cord-006860-a3b8hyyr	1109	35	Hepato	Hepato	NNP
cord-006860-a3b8hyyr	1109	36	Quick	Quick	NNP
cord-006860-a3b8hyyr	1109	37	,	,	,
cord-006860-a3b8hyyr	1109	38	as	as	RB
cord-006860-a3b8hyyr	1109	39	well	well	RB
cord-006860-a3b8hyyr	1109	40	as	as	IN
cord-006860-a3b8hyyr	1109	41	the	the	DT
cord-006860-a3b8hyyr	1109	42	factors	factor	NNS
cord-006860-a3b8hyyr	1109	43	II	II	NNP
cord-006860-a3b8hyyr	1109	44	,	,	,
cord-006860-a3b8hyyr	1109	45	V	v	NN
cord-006860-a3b8hyyr	1109	46	,	,	,
cord-006860-a3b8hyyr	1109	47	VII	VII	NNP
cord-006860-a3b8hyyr	1109	48	,	,	,
cord-006860-a3b8hyyr	1109	49	X	X	NNP
cord-006860-a3b8hyyr	1109	50	,	,	,
cord-006860-a3b8hyyr	1109	51	and	and	CC
cord-006860-a3b8hyyr	1109	52	VIII	VIII	NNP
cord-006860-a3b8hyyr	1109	53	.	.	.
cord-006860-a3b8hyyr	1110	1	Results	result	NNS
cord-006860-a3b8hyyr	1110	2	:	:	:
cord-006860-a3b8hyyr	1111	1	Within	within	IN
cord-006860-a3b8hyyr	1111	2	run	run	NN
cord-006860-a3b8hyyr	1111	3	CVs	cv	NNS
cord-006860-a3b8hyyr	1111	4	of	of	IN
cord-006860-a3b8hyyr	1111	5	the	the	DT
cord-006860-a3b8hyyr	1111	6	clotting	clotting	NN
cord-006860-a3b8hyyr	1111	7	tests	test	NNS
cord-006860-a3b8hyyr	1111	8	were	be	VBD
cord-006860-a3b8hyyr	1111	9	below	below	IN
cord-006860-a3b8hyyr	1111	10	2	2	CD
cord-006860-a3b8hyyr	1111	11	%	%	NN
cord-006860-a3b8hyyr	1111	12	(	(	-LRB-
cord-006860-a3b8hyyr	1111	13	calculated	calculate	VBN
cord-006860-a3b8hyyr	1111	14	on	on	IN
cord-006860-a3b8hyyr	1111	15	the	the	DT
cord-006860-a3b8hyyr	1111	16	basis	basis	NN
cord-006860-a3b8hyyr	1111	17	of	of	IN
cord-006860-a3b8hyyr	1111	18	seconds	second	NNS
cord-006860-a3b8hyyr	1111	19	)	)	-RRB-
cord-006860-a3b8hyyr	1111	20	in	in	IN
cord-006860-a3b8hyyr	1111	21	most	most	JJS
cord-006860-a3b8hyyr	1111	22	cases	case	NNS
cord-006860-a3b8hyyr	1111	23	,	,	,
cord-006860-a3b8hyyr	1111	24	day	day	NN
cord-006860-a3b8hyyr	1111	25	to	to	IN
cord-006860-a3b8hyyr	1111	26	day	day	NN
cord-006860-a3b8hyyr	1111	27	CVs	cv	NNS
cord-006860-a3b8hyyr	1111	28	below	below	IN
cord-006860-a3b8hyyr	1111	29	4	4	CD
cord-006860-a3b8hyyr	1111	30	%	%	NN
cord-006860-a3b8hyyr	1111	31	(	(	-LRB-
cord-006860-a3b8hyyr	1111	32	not	not	RB
cord-006860-a3b8hyyr	1111	33	measured	measure	VBN
cord-006860-a3b8hyyr	1111	34	for	for	IN
cord-006860-a3b8hyyr	1111	35	factors	factor	NNS
cord-006860-a3b8hyyr	1111	36	,	,	,
cord-006860-a3b8hyyr	1111	37	yet	yet	RB
cord-006860-a3b8hyyr	1111	38	)	)	-RRB-
cord-006860-a3b8hyyr	1111	39	.	.	.
cord-006860-a3b8hyyr	1112	1	AT	at	IN
cord-006860-a3b8hyyr	1112	2	III	III	NNP
cord-006860-a3b8hyyr	1112	3	yielded	yield	VBD
cord-006860-a3b8hyyr	1112	4	within	within	IN
cord-006860-a3b8hyyr	1112	5	run	run	NN
cord-006860-a3b8hyyr	1112	6	CVs	cv	NNS
cord-006860-a3b8hyyr	1112	7	below	below	IN
cord-006860-a3b8hyyr	1112	8	3	3	CD
cord-006860-a3b8hyyr	1112	9	%	%	NN
cord-006860-a3b8hyyr	1112	10	in	in	IN
cord-006860-a3b8hyyr	1112	11	the	the	DT
cord-006860-a3b8hyyr	1112	12	decision	decision	NN
cord-006860-a3b8hyyr	1112	13	range	range	NN
cord-006860-a3b8hyyr	1112	14	.	.	.
cord-006860-a3b8hyyr	1113	1	Measuring	measure	VBG
cord-006860-a3b8hyyr	1113	2	ranges	range	NNS
cord-006860-a3b8hyyr	1113	3	:	:	:
cord-006860-a3b8hyyr	1113	4	AT	at	IN
cord-006860-a3b8hyyr	1113	5	III	III	NNP
cord-006860-a3b8hyyr	1113	6	:	:	:
cord-006860-a3b8hyyr	1113	7	20	20	CD
cord-006860-a3b8hyyr	1113	8	-	-	SYM
cord-006860-a3b8hyyr	1113	9	140	140	CD
cord-006860-a3b8hyyr	1113	10	%	%	NN
cord-006860-a3b8hyyr	1113	11	;	;	,
cord-006860-a3b8hyyr	1113	12	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1113	13	:	:	:
cord-006860-a3b8hyyr	1113	14	1.3	1.3	CD
cord-006860-a3b8hyyr	1113	15	-	-	SYM
cord-006860-a3b8hyyr	1113	16	9.0	9.0	CD
cord-006860-a3b8hyyr	1113	17	g	g	NN
cord-006860-a3b8hyyr	1113	18	/	/	SYM
cord-006860-a3b8hyyr	1113	19	l	l	NN
cord-006860-a3b8hyyr	1113	20	(	(	-LRB-
cord-006860-a3b8hyyr	1113	21	plasma	plasma	NN
cord-006860-a3b8hyyr	1113	22	-dilution	-dilution	NN
cord-006860-a3b8hyyr	1113	23	1/20	1/20	CD
cord-006860-a3b8hyyr	1113	24	)	)	-RRB-
cord-006860-a3b8hyyr	1113	25	,	,	,
cord-006860-a3b8hyyr	1113	26	after	after	IN
cord-006860-a3b8hyyr	1113	27	rerun	rerun	NN
cord-006860-a3b8hyyr	1113	28	with	with	IN
cord-006860-a3b8hyyr	1113	29	other	other	JJ
cord-006860-a3b8hyyr	1113	30	dilutions	dilution	NNS
cord-006860-a3b8hyyr	1113	31	:	:	:
cord-006860-a3b8hyyr	1113	32	from	from	IN
cord-006860-a3b8hyyr	1113	33	0.3	0.3	CD
cord-006860-a3b8hyyr	1113	34	g/1	g/1	NNS
cord-006860-a3b8hyyr	1113	35	(	(	-LRB-
cord-006860-a3b8hyyr	1113	36	dilution	dilution	NN
cord-006860-a3b8hyyr	1113	37	:	:	:
cord-006860-a3b8hyyr	1113	38	1/5	1/5	CD
cord-006860-a3b8hyyr	1113	39	)	)	-RRB-
cord-006860-a3b8hyyr	1113	40	to	to	IN
cord-006860-a3b8hyyr	1113	41	18	18	CD
cord-006860-a3b8hyyr	1113	42	g[L	g[l	ADD
cord-006860-a3b8hyyr	1113	43	(	(	-LRB-
cord-006860-a3b8hyyr	1113	44	dilution	dilution	NN
cord-006860-a3b8hyyr	1113	45	:	:	:
cord-006860-a3b8hyyr	1113	46	1/40	1/40	CD
cord-006860-a3b8hyyr	1113	47	)	)	-RRB-
cord-006860-a3b8hyyr	1113	48	.	.	.
cord-006860-a3b8hyyr	1114	1	Method	method	NN
cord-006860-a3b8hyyr	1114	2	comparisons	comparison	NNS
cord-006860-a3b8hyyr	1114	3	,	,	,
cord-006860-a3b8hyyr	1114	4	using	use	VBG
cord-006860-a3b8hyyr	1114	5	STA	STA	NNP
cord-006860-a3b8hyyr	1114	6	as	as	IN
cord-006860-a3b8hyyr	1114	7	reference	reference	NN
cord-006860-a3b8hyyr	1114	8	,	,	,
cord-006860-a3b8hyyr	1114	9	yielded	yield	VBD
cord-006860-a3b8hyyr	1114	10	slopes	slope	NNS
cord-006860-a3b8hyyr	1114	11	close	close	JJ
cord-006860-a3b8hyyr	1114	12	to	to	IN
cord-006860-a3b8hyyr	1114	13	1.00	1.00	CD
cord-006860-a3b8hyyr	1114	14	and	and	CC
cord-006860-a3b8hyyr	1114	15	negligible	negligible	JJ
cord-006860-a3b8hyyr	1114	16	intercepts	intercept	NNS
cord-006860-a3b8hyyr	1114	17	.	.	.
cord-006860-a3b8hyyr	1115	1	Throughput	throughput	NN
cord-006860-a3b8hyyr	1115	2	:	:	:
cord-006860-a3b8hyyr	1115	3	With	with	IN
cord-006860-a3b8hyyr	1115	4	routine	routine	JJ
cord-006860-a3b8hyyr	1115	5	clotting	clotting	NN
cord-006860-a3b8hyyr	1115	6	tests	test	NNS
cord-006860-a3b8hyyr	1115	7	about	about	IN
cord-006860-a3b8hyyr	1115	8	100	100	CD
cord-006860-a3b8hyyr	1115	9	tests	test	NNS
cord-006860-a3b8hyyr	1115	10	/	/	SYM
cord-006860-a3b8hyyr	1115	11	h	h	NN
cord-006860-a3b8hyyr	1115	12	,	,	,
cord-006860-a3b8hyyr	1115	13	in	in	IN
cord-006860-a3b8hyyr	1115	14	a	a	DT
cord-006860-a3b8hyyr	1115	15	sample	sample	NN
cord-006860-a3b8hyyr	1115	16	selective	selective	JJ
cord-006860-a3b8hyyr	1115	17	access	access	NN
cord-006860-a3b8hyyr	1115	18	mode	mode	NN
cord-006860-a3b8hyyr	1115	19	.	.	.
cord-006860-a3b8hyyr	1116	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1116	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	1116	3	,	,	,
cord-006860-a3b8hyyr	1116	4	that	that	IN
cord-006860-a3b8hyyr	1116	5	STA	STA	NNP
cord-006860-a3b8hyyr	1116	6	Compact	Compact	NNP
cord-006860-a3b8hyyr	1116	7	allows	allow	VBZ
cord-006860-a3b8hyyr	1116	8	precise	precise	JJ
cord-006860-a3b8hyyr	1116	9	measurement	measurement	NN
cord-006860-a3b8hyyr	1116	10	of	of	IN
cord-006860-a3b8hyyr	1116	11	routine	routine	JJ
cord-006860-a3b8hyyr	1116	12	and	and	CC
cord-006860-a3b8hyyr	1116	13	special	special	JJ
cord-006860-a3b8hyyr	1116	14	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1116	15	tests	test	NNS
cord-006860-a3b8hyyr	1116	16	.	.	.
cord-006860-a3b8hyyr	1117	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1117	2	is	be	VBZ
cord-006860-a3b8hyyr	1117	3	also	also	RB
cord-006860-a3b8hyyr	1117	4	a	a	DT
cord-006860-a3b8hyyr	1117	5	reliable	reliable	JJ
cord-006860-a3b8hyyr	1117	6	system	system	NN
cord-006860-a3b8hyyr	1117	7	for	for	IN
cord-006860-a3b8hyyr	1117	8	photometric	photometric	JJ
cord-006860-a3b8hyyr	1117	9	tests	test	NNS
cord-006860-a3b8hyyr	1117	10	and	and	CC
cord-006860-a3b8hyyr	1117	11	well	well	RB
cord-006860-a3b8hyyr	1117	12	suited	suited	JJ
cord-006860-a3b8hyyr	1117	13	for	for	IN
cord-006860-a3b8hyyr	1117	14	intermediate	intermediate	JJ
cord-006860-a3b8hyyr	1117	15	workloads	workload	NNS
cord-006860-a3b8hyyr	1117	16	as	as	RB
cord-006860-a3b8hyyr	1117	17	well	well	RB
cord-006860-a3b8hyyr	1117	18	as	as	IN
cord-006860-a3b8hyyr	1117	19	STAT	stat	NN
cord-006860-a3b8hyyr	1117	20	analyses	analysis	NNS
cord-006860-a3b8hyyr	1117	21	.	.	.
cord-006860-a3b8hyyr	1118	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1118	2	did	do	VBD
cord-006860-a3b8hyyr	1118	3	evaluate	evaluate	VB
cord-006860-a3b8hyyr	1118	4	PTT	PTT	NNP
cord-006860-a3b8hyyr	1118	5	LT	LT	NNP
cord-006860-a3b8hyyr	1118	6	,	,	,
cord-006860-a3b8hyyr	1118	7	a	a	DT
cord-006860-a3b8hyyr	1118	8	new	new	JJ
cord-006860-a3b8hyyr	1118	9	liquid	liquid	NN
cord-006860-a3b8hyyr	1118	10	,	,	,
cord-006860-a3b8hyyr	1118	11	silica	silica	NN
cord-006860-a3b8hyyr	1118	12	based	base	VBN
cord-006860-a3b8hyyr	1118	13	PTT	PTT	NNP
cord-006860-a3b8hyyr	1118	14	reagent	reagent	NN
cord-006860-a3b8hyyr	1118	15	.	.	.
cord-006860-a3b8hyyr	1119	1	Special	special	JJ
cord-006860-a3b8hyyr	1119	2	attention	attention	NN
cord-006860-a3b8hyyr	1119	3	was	be	VBD
cord-006860-a3b8hyyr	1119	4	given	give	VBN
cord-006860-a3b8hyyr	1119	5	to	to	TO
cord-006860-a3b8hyyr	1119	6	reference	reference	NN
cord-006860-a3b8hyyr	1119	7	interval	interval	NN
cord-006860-a3b8hyyr	1119	8	and	and	CC
cord-006860-a3b8hyyr	1119	9	heparin	heparin	NN
cord-006860-a3b8hyyr	1119	10	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	1119	11	.	.	.
cord-006860-a3b8hyyr	1120	1	The	the	DT
cord-006860-a3b8hyyr	1120	2	new	new	JJ
cord-006860-a3b8hyyr	1120	3	reagent	reagent	NN
cord-006860-a3b8hyyr	1120	4	is	be	VBZ
cord-006860-a3b8hyyr	1120	5	well	well	RB
cord-006860-a3b8hyyr	1120	6	suited	suited	JJ
cord-006860-a3b8hyyr	1120	7	for	for	IN
cord-006860-a3b8hyyr	1120	8	the	the	DT
cord-006860-a3b8hyyr	1120	9	measurement	measurement	NN
cord-006860-a3b8hyyr	1120	10	of	of	IN
cord-006860-a3b8hyyr	1120	11	intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	1120	12	clotting	clotting	NN
cord-006860-a3b8hyyr	1120	13	factors	factor	NNS
cord-006860-a3b8hyyr	1120	14	and	and	CC
cord-006860-a3b8hyyr	1120	15	is	be	VBZ
cord-006860-a3b8hyyr	1120	16	reported	report	VBN
cord-006860-a3b8hyyr	1120	17	to	to	TO
cord-006860-a3b8hyyr	1120	18	have	have	VB
cord-006860-a3b8hyyr	1120	19	high	high	JJ
cord-006860-a3b8hyyr	1120	20	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	1120	21	for	for	IN
cord-006860-a3b8hyyr	1120	22	lupus	lupus	NN
cord-006860-a3b8hyyr	1120	23	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	1120	24	(	(	-LRB-
cord-006860-a3b8hyyr	1120	25	higher	high	JJR
cord-006860-a3b8hyyr	1120	26	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	1120	27	than	than	IN
cord-006860-a3b8hyyr	1120	28	STA	STA	NNP
cord-006860-a3b8hyyr	1120	29	aPTT	aptt	NN
cord-006860-a3b8hyyr	1120	30	[	[	-LRB-
cord-006860-a3b8hyyr	1120	31	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	1120	32	Mannheim	Mannheim	NNP
cord-006860-a3b8hyyr	1120	33	=	=	SYM
cord-006860-a3b8hyyr	1120	34	BM	BM	NNP
cord-006860-a3b8hyyr	1120	35	]	]	-RRB-
cord-006860-a3b8hyyr	1120	36	)	)	-RRB-
cord-006860-a3b8hyyr	1120	37	.	.	.
cord-006860-a3b8hyyr	1121	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1121	2	is	be	VBZ
cord-006860-a3b8hyyr	1121	3	stable	stable	JJ
cord-006860-a3b8hyyr	1121	4	for	for	IN
cord-006860-a3b8hyyr	1121	5	4	4	CD
cord-006860-a3b8hyyr	1121	6	days	day	NNS
cord-006860-a3b8hyyr	1121	7	in	in	IN
cord-006860-a3b8hyyr	1121	8	the	the	DT
cord-006860-a3b8hyyr	1121	9	cooled	cool	VBN
cord-006860-a3b8hyyr	1121	10	compartment	compartment	NN
cord-006860-a3b8hyyr	1121	11	of	of	IN
cord-006860-a3b8hyyr	1121	12	the	the	DT
cord-006860-a3b8hyyr	1121	13	STA	STA	NNP
cord-006860-a3b8hyyr	1121	14	analyzer	analyzer	NN
cord-006860-a3b8hyyr	1121	15	.	.	.
cord-006860-a3b8hyyr	1122	1	Methods	method	NNS
cord-006860-a3b8hyyr	1122	2	:	:	:
cord-006860-a3b8hyyr	1123	1	All	all	DT
cord-006860-a3b8hyyr	1123	2	experiments	experiment	NNS
cord-006860-a3b8hyyr	1123	3	were	be	VBD
cord-006860-a3b8hyyr	1123	4	made	make	VBN
cord-006860-a3b8hyyr	1123	5	on	on	IN
cord-006860-a3b8hyyr	1123	6	STA	STA	NNP
cord-006860-a3b8hyyr	1123	7	.	.	.
cord-006860-a3b8hyyr	1124	1	For	for	IN
cord-006860-a3b8hyyr	1124	2	comparison	comparison	NN
cord-006860-a3b8hyyr	1124	3	,	,	,
cord-006860-a3b8hyyr	1124	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	1124	5	used	use	VBD
cord-006860-a3b8hyyr	1124	6	three	three	CD
cord-006860-a3b8hyyr	1124	7	other	other	JJ
cord-006860-a3b8hyyr	1124	8	PTT	PTT	NNP
cord-006860-a3b8hyyr	1124	9	reagents	reagent	NNS
cord-006860-a3b8hyyr	1124	10	(	(	-LRB-
cord-006860-a3b8hyyr	1124	11	a	a	DT
cord-006860-a3b8hyyr	1124	12	lab	lab	NN
cord-006860-a3b8hyyr	1124	13	.	.	.
cord-006860-a3b8hyyr	1125	1	routine	routine	JJ
cord-006860-a3b8hyyr	1125	2	,	,	,
cord-006860-a3b8hyyr	1125	3	silica	silica	NN
cord-006860-a3b8hyyr	1125	4	based	base	VBN
cord-006860-a3b8hyyr	1125	5	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	1125	6	,	,	,
cord-006860-a3b8hyyr	1125	7	as	as	RB
cord-006860-a3b8hyyr	1125	8	well	well	RB
cord-006860-a3b8hyyr	1125	9	as	as	IN
cord-006860-a3b8hyyr	1125	10	STA	STA	NNP
cord-006860-a3b8hyyr	1125	11	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	1125	12	and	and	CC
cord-006860-a3b8hyyr	1125	13	STA	STA	NNP
cord-006860-a3b8hyyr	1125	14	PTT	PTT	NNP
cord-006860-a3b8hyyr	1125	15	Kaolin	Kaolin	NNP
cord-006860-a3b8hyyr	1125	16	from	from	IN
cord-006860-a3b8hyyr	1125	17	BM	BM	NNP
cord-006860-a3b8hyyr	1125	18	)	)	-RRB-
cord-006860-a3b8hyyr	1125	19	.	.	.
cord-006860-a3b8hyyr	1126	1	In	in	IN
cord-006860-a3b8hyyr	1126	2	addition	addition	NN
cord-006860-a3b8hyyr	1126	3	,	,	,
cord-006860-a3b8hyyr	1126	4	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1126	5	time	time	NN
cord-006860-a3b8hyyr	1127	1	(	(	-LRB-
cord-006860-a3b8hyyr	1127	2	3	3	CD
cord-006860-a3b8hyyr	1127	3	U	u	NN
cord-006860-a3b8hyyr	1127	4	/	/	SYM
cord-006860-a3b8hyyr	1127	5	mL	ml	NN
cord-006860-a3b8hyyr	1127	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1127	7	,	,	,
cord-006860-a3b8hyyr	1127	8	STA	STA	NNP
cord-006860-a3b8hyyr	1127	9	Thrombin	Thrombin	NNP
cord-006860-a3b8hyyr	1127	10	reagent	reagent	NN
cord-006860-a3b8hyyr	1127	11	)	)	-RRB-
cord-006860-a3b8hyyr	1127	12	and	and	CC
cord-006860-a3b8hyyr	1127	13	heparin	heparin	NNP
cord-006860-a3b8hyyr	1127	14	(	(	-LRB-
cord-006860-a3b8hyyr	1127	15	chromogenic	chromogenic	NNP
cord-006860-a3b8hyyr	1127	16	Xa	Xa	NNP
cord-006860-a3b8hyyr	1127	17	test	test	NN
cord-006860-a3b8hyyr	1127	18	,	,	,
cord-006860-a3b8hyyr	1127	19	Rotachrom	Rotachrom	NNP
cord-006860-a3b8hyyr	1127	20	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	1127	21	)	)	-RRB-
cord-006860-a3b8hyyr	1127	22	were	be	VBD
cord-006860-a3b8hyyr	1127	23	measured	measure	VBN
cord-006860-a3b8hyyr	1127	24	.	.	.
cord-006860-a3b8hyyr	1128	1	Results	result	NNS
cord-006860-a3b8hyyr	1128	2	:	:	:
cord-006860-a3b8hyyr	1129	1	Within	within	IN
cord-006860-a3b8hyyr	1129	2	mn	mn	NNP
cord-006860-a3b8hyyr	1129	3	imprecision	imprecision	NN
cord-006860-a3b8hyyr	1129	4	(	(	-LRB-
cord-006860-a3b8hyyr	1129	5	n=21	n=21	NNP
cord-006860-a3b8hyyr	1129	6	)	)	-RRB-
cord-006860-a3b8hyyr	1129	7	was	be	VBD
cord-006860-a3b8hyyr	1129	8	below	below	IN
cord-006860-a3b8hyyr	1129	9	0.7	0.7	CD
cord-006860-a3b8hyyr	1129	10	%	%	NN
cord-006860-a3b8hyyr	1129	11	CV	cv	NN
cord-006860-a3b8hyyr	1129	12	in	in	IN
cord-006860-a3b8hyyr	1129	13	the	the	DT
cord-006860-a3b8hyyr	1129	14	normal	normal	JJ
cord-006860-a3b8hyyr	1129	15	range	range	NN
cord-006860-a3b8hyyr	1129	16	and	and	CC
cord-006860-a3b8hyyr	1129	17	in	in	IN
cord-006860-a3b8hyyr	1129	18	two	two	CD
cord-006860-a3b8hyyr	1129	19	controls	control	NNS
cord-006860-a3b8hyyr	1129	20	(	(	-LRB-
cord-006860-a3b8hyyr	1129	21	mean	mean	VB
cord-006860-a3b8hyyr	1129	22	values	value	NNS
cord-006860-a3b8hyyr	1129	23	:	:	:
cord-006860-a3b8hyyr	1129	24	35	35	CD
cord-006860-a3b8hyyr	1129	25	s	s	NNS
cord-006860-a3b8hyyr	1129	26	,	,	,
cord-006860-a3b8hyyr	1129	27	76	76	CD
cord-006860-a3b8hyyr	1129	28	s	s	NNPS
cord-006860-a3b8hyyr	1129	29	)	)	-RRB-
cord-006860-a3b8hyyr	1129	30	,	,	,
cord-006860-a3b8hyyr	1129	31	and	and	CC
cord-006860-a3b8hyyr	1129	32	1.4	1.4	CD
cord-006860-a3b8hyyr	1129	33	%	%	NN
cord-006860-a3b8hyyr	1129	34	in	in	IN
cord-006860-a3b8hyyr	1129	35	a	a	DT
cord-006860-a3b8hyyr	1129	36	heparin	heparin	NN
cord-006860-a3b8hyyr	1129	37	plasma	plasma	NN
cord-006860-a3b8hyyr	1129	38	(	(	-LRB-
cord-006860-a3b8hyyr	1129	39	mean	mean	VB
cord-006860-a3b8hyyr	1129	40	:	:	:
cord-006860-a3b8hyyr	1129	41	81	81	CD
cord-006860-a3b8hyyr	1129	42	s	s	NN
cord-006860-a3b8hyyr	1129	43	)	)	-RRB-
cord-006860-a3b8hyyr	1129	44	.	.	.
cord-006860-a3b8hyyr	1130	1	Between	between	IN
cord-006860-a3b8hyyr	1130	2	day	day	NN
cord-006860-a3b8hyyr	1130	3	imprecision	imprecision	NN
cord-006860-a3b8hyyr	1130	4	(	(	-LRB-
cord-006860-a3b8hyyr	1130	5	d=10	d=10	NN
cord-006860-a3b8hyyr	1130	6	)	)	-RRB-
cord-006860-a3b8hyyr	1130	7	was	be	VBD
cord-006860-a3b8hyyr	1130	8	below	below	IN
cord-006860-a3b8hyyr	1130	9	3	3	CD
cord-006860-a3b8hyyr	1130	10	%	%	NN
cord-006860-a3b8hyyr	1130	11	in	in	IN
cord-006860-a3b8hyyr	1130	12	two	two	CD
cord-006860-a3b8hyyr	1130	13	controls	control	NNS
cord-006860-a3b8hyyr	1130	14	(	(	-LRB-
cord-006860-a3b8hyyr	1130	15	mean	mean	VB
cord-006860-a3b8hyyr	1130	16	values	value	NNS
cord-006860-a3b8hyyr	1130	17	:	:	:
cord-006860-a3b8hyyr	1130	18	34	34	CD
cord-006860-a3b8hyyr	1130	19	s	s	NNS
cord-006860-a3b8hyyr	1130	20	and	and	CC
cord-006860-a3b8hyyr	1130	21	58	58	CD
cord-006860-a3b8hyyr	1130	22	s	s	NNPS
cord-006860-a3b8hyyr	1130	23	)	)	-RRB-
cord-006860-a3b8hyyr	1130	24	.	.	.
cord-006860-a3b8hyyr	1131	1	The	the	DT
cord-006860-a3b8hyyr	1131	2	upper	upper	JJ
cord-006860-a3b8hyyr	1131	3	limit	limit	NN
cord-006860-a3b8hyyr	1131	4	of	of	IN
cord-006860-a3b8hyyr	1131	5	the	the	DT
cord-006860-a3b8hyyr	1131	6	reference	reference	NN
cord-006860-a3b8hyyr	1131	7	range	range	NN
cord-006860-a3b8hyyr	1131	8	is	be	VBZ
cord-006860-a3b8hyyr	1131	9	40	40	CD
cord-006860-a3b8hyyr	1131	10	s	s	NNS
cord-006860-a3b8hyyr	1131	11	(	(	-LRB-
cord-006860-a3b8hyyr	1131	12	97.5	97.5	CD
cord-006860-a3b8hyyr	1131	13	th	th	CD
cord-006860-a3b8hyyr	1131	14	perc	perc	NNS
cord-006860-a3b8hyyr	1131	15	.	.	.
cord-006860-a3b8hyyr	1132	1	,	,	,
cord-006860-a3b8hyyr	1132	2	median	median	NN
cord-006860-a3b8hyyr	1132	3	:	:	:
cord-006860-a3b8hyyr	1132	4	32	32	CD
cord-006860-a3b8hyyr	1132	5	s	s	NN
cord-006860-a3b8hyyr	1132	6	;	;	:
cord-006860-a3b8hyyr	1132	7	90	90	CD
cord-006860-a3b8hyyr	1132	8	patients	patient	NNS
cord-006860-a3b8hyyr	1132	9	with	with	IN
cord-006860-a3b8hyyr	1132	10	normal	normal	JJ
cord-006860-a3b8hyyr	1132	11	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1132	12	status	status	NN
cord-006860-a3b8hyyr	1132	13	[	[	-LRB-
cord-006860-a3b8hyyr	1132	14	routine	routine	NN
cord-006860-a3b8hyyr	1132	15	aPTT	aptt	NN
cord-006860-a3b8hyyr	1132	16	,	,	,
cord-006860-a3b8hyyr	1132	17	fib	fib	NNP
cord-006860-a3b8hyyr	1132	18	.	.	.
cord-006860-a3b8hyyr	1133	1	,	,	,
cord-006860-a3b8hyyr	1133	2	PT	PT	NNP
cord-006860-a3b8hyyr	1133	3	]	]	-RRB-
cord-006860-a3b8hyyr	1133	4	,	,	,
cord-006860-a3b8hyyr	1133	5	median	median	JJ
cord-006860-a3b8hyyr	1133	6	age	age	NN
cord-006860-a3b8hyyr	1133	7	:	:	:
cord-006860-a3b8hyyr	1133	8	54	54	CD
cord-006860-a3b8hyyr	1133	9	years	year	NNS
cord-006860-a3b8hyyr	1133	10	)	)	-RRB-
cord-006860-a3b8hyyr	1133	11	;	;	:
cord-006860-a3b8hyyr	1133	12	almost	almost	RB
cord-006860-a3b8hyyr	1133	13	identical	identical	JJ
cord-006860-a3b8hyyr	1133	14	reference	reference	NN
cord-006860-a3b8hyyr	1133	15	ranges	range	NNS
cord-006860-a3b8hyyr	1133	16	were	be	VBD
cord-006860-a3b8hyyr	1133	17	obtained	obtain	VBN
cord-006860-a3b8hyyr	1133	18	with	with	IN
cord-006860-a3b8hyyr	1133	19	STA	STA	NNP
cord-006860-a3b8hyyr	1133	20	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	1133	21	and	and	CC
cord-006860-a3b8hyyr	1133	22	the	the	DT
cord-006860-a3b8hyyr	1133	23	routine	routine	JJ
cord-006860-a3b8hyyr	1133	24	PTT	PTT	NNP
cord-006860-a3b8hyyr	1133	25	reagent	reagent	NN
cord-006860-a3b8hyyr	1133	26	,	,	,
cord-006860-a3b8hyyr	1133	27	while	while	IN
cord-006860-a3b8hyyr	1133	28	STA	STA	NNP
cord-006860-a3b8hyyr	1133	29	PTT	PTT	NNP
cord-006860-a3b8hyyr	1133	30	Kaolin	Kaolin	NNP
cord-006860-a3b8hyyr	1133	31	showed	show	VBD
cord-006860-a3b8hyyr	1133	32	significantly	significantly	RB
cord-006860-a3b8hyyr	1133	33	lower	low	JJR
cord-006860-a3b8hyyr	1133	34	values	value	NNS
cord-006860-a3b8hyyr	1133	35	(	(	-LRB-
cord-006860-a3b8hyyr	1133	36	97.5th	97.5th	CD
cord-006860-a3b8hyyr	1133	37	perc	perc	NNS
cord-006860-a3b8hyyr	1133	38	.	.	.
cord-006860-a3b8hyyr	1134	1	:	:	:
cord-006860-a3b8hyyr	1134	2	33	33	CD
cord-006860-a3b8hyyr	1134	3	s	s	NNPS
cord-006860-a3b8hyyr	1134	4	,	,	,
cord-006860-a3b8hyyr	1134	5	median	median	JJ
cord-006860-a3b8hyyr	1134	6	28	28	CD
cord-006860-a3b8hyyr	1134	7	s	s	NNPS
cord-006860-a3b8hyyr	1134	8	)	)	-RRB-
cord-006860-a3b8hyyr	1134	9	.	.	.
cord-006860-a3b8hyyr	1135	1	Method	method	NN
cord-006860-a3b8hyyr	1135	2	comparison	comparison	NN
cord-006860-a3b8hyyr	1135	3	study	study	NN
cord-006860-a3b8hyyr	1135	4	:	:	:
cord-006860-a3b8hyyr	1136	1	good	good	JJ
cord-006860-a3b8hyyr	1136	2	agreement	agreement	NN
cord-006860-a3b8hyyr	1136	3	using	use	VBG
cord-006860-a3b8hyyr	1136	4	plasmas	plasma	NNS
cord-006860-a3b8hyyr	1136	5	from	from	IN
cord-006860-a3b8hyyr	1136	6	patients	patient	NNS
cord-006860-a3b8hyyr	1136	7	without	without	IN
cord-006860-a3b8hyyr	1136	8	heparin	heparin	NN
cord-006860-a3b8hyyr	1136	9	:	:	:
cord-006860-a3b8hyyr	1137	1	(	(	-LRB-
cord-006860-a3b8hyyr	1137	2	y=	y=	NNP
cord-006860-a3b8hyyr	1137	3	0A	0A	NNP
cord-006860-a3b8hyyr	1137	4	+	+	CC
cord-006860-a3b8hyyr	1138	1	0.98	0.98	CD
cord-006860-a3b8hyyr	1138	2	x	x	SYM
cord-006860-a3b8hyyr	1138	3	,	,	,
cord-006860-a3b8hyyr	1138	4	n=	n=	NNP
cord-006860-a3b8hyyr	1138	5	198	198	CD
cord-006860-a3b8hyyr	1138	6	,	,	,
cord-006860-a3b8hyyr	1138	7	range	range	VBP
cord-006860-a3b8hyyr	1138	8	of(x	of(x	CD
cord-006860-a3b8hyyr	1138	9	)	)	-RRB-
cord-006860-a3b8hyyr	1138	10	from	from	IN
cord-006860-a3b8hyyr	1138	11	25	25	CD
cord-006860-a3b8hyyr	1138	12	to	to	TO
cord-006860-a3b8hyyr	1138	13	79	79	CD
cord-006860-a3b8hyyr	1138	14	s	s	NNS
cord-006860-a3b8hyyr	1138	15	,	,	,
cord-006860-a3b8hyyr	1138	16	r	r	NN
cord-006860-a3b8hyyr	1138	17	=	=	SYM
cord-006860-a3b8hyyr	1138	18	0.97	0.97	CD
cord-006860-a3b8hyyr	1138	19	;	;	.
cord-006860-a3b8hyyr	1139	1	x	x	LS
cord-006860-a3b8hyyr	1139	2	=	=	NFP
cord-006860-a3b8hyyr	1140	1	STA	STA	NNP
cord-006860-a3b8hyyr	1140	2	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	1140	3	)	)	-RRB-
cord-006860-a3b8hyyr	1140	4	.	.	.
cord-006860-a3b8hyyr	1141	1	The	the	DT
cord-006860-a3b8hyyr	1141	2	median	median	JJ
cord-006860-a3b8hyyr	1141	3	values	value	NNS
cord-006860-a3b8hyyr	1141	4	from	from	IN
cord-006860-a3b8hyyr	1141	5	54	54	CD
cord-006860-a3b8hyyr	1141	6	patients	patient	NNS
cord-006860-a3b8hyyr	1141	7	under	under	IN
cord-006860-a3b8hyyr	1141	8	high	high	JJ
cord-006860-a3b8hyyr	1141	9	dose	dose	NN
cord-006860-a3b8hyyr	1141	10	heparin	heparin	NN
cord-006860-a3b8hyyr	1141	11	were	be	VBD
cord-006860-a3b8hyyr	1141	12	:	:	:
cord-006860-a3b8hyyr	1141	13	routine	routine	JJ
cord-006860-a3b8hyyr	1141	14	PTT	PTT	NNP
cord-006860-a3b8hyyr	1141	15	:	:	:
cord-006860-a3b8hyyr	1141	16	81	81	CD
cord-006860-a3b8hyyr	1141	17	s	s	NNS
cord-006860-a3b8hyyr	1141	18	,	,	,
cord-006860-a3b8hyyr	1141	19	STA	STA	NNP
cord-006860-a3b8hyyr	1141	20	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	1141	21	:	:	:
cord-006860-a3b8hyyr	1141	22	75	75	CD
cord-006860-a3b8hyyr	1141	23	s	s	NNPS
cord-006860-a3b8hyyr	1141	24	,	,	,
cord-006860-a3b8hyyr	1141	25	PTT	PTT	NNP
cord-006860-a3b8hyyr	1141	26	-LT	-lt	XX
cord-006860-a3b8hyyr	1141	27	:	:	:
cord-006860-a3b8hyyr	1142	1	82	82	CD
cord-006860-a3b8hyyr	1142	2	s0	s0	NN
cord-006860-a3b8hyyr	1143	1	STA	STA	NNP
cord-006860-a3b8hyyr	1143	2	PTT	PTT	NNP
cord-006860-a3b8hyyr	1143	3	Kaolin	Kaolin	NNP
cord-006860-a3b8hyyr	1143	4	54	54	CD
cord-006860-a3b8hyyr	1143	5	s	s	NNPS
cord-006860-a3b8hyyr	1143	6	,	,	.
cord-006860-a3b8hyyr	1144	1	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1144	2	time	time	NN
cord-006860-a3b8hyyr	1144	3	37	37	CD
cord-006860-a3b8hyyr	1144	4	s	s	NNS
cord-006860-a3b8hyyr	1144	5	and	and	CC
cord-006860-a3b8hyyr	1144	6	heparin	heparin	NN
cord-006860-a3b8hyyr	1144	7	0.5	0.5	CD
cord-006860-a3b8hyyr	1144	8	IU	IU	NNP
cord-006860-a3b8hyyr	1144	9	/	/	,
cord-006860-a3b8hyyr	1144	10	mL	ml	NN
cord-006860-a3b8hyyr	1145	1	In	in	IN
cord-006860-a3b8hyyr	1145	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	1145	3	,	,	,
cord-006860-a3b8hyyr	1145	4	results	result	NNS
cord-006860-a3b8hyyr	1145	5	of	of	IN
cord-006860-a3b8hyyr	1145	6	the	the	DT
cord-006860-a3b8hyyr	1145	7	new	new	JJ
cord-006860-a3b8hyyr	1145	8	reagent	reagent	NN
cord-006860-a3b8hyyr	1145	9	compare	compare	VB
cord-006860-a3b8hyyr	1145	10	well	well	RB
cord-006860-a3b8hyyr	1145	11	to	to	IN
cord-006860-a3b8hyyr	1145	12	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1145	13	routine	routine	JJ
cord-006860-a3b8hyyr	1145	14	PTT	ptt	NN
cord-006860-a3b8hyyr	1145	15	and	and	CC
cord-006860-a3b8hyyr	1145	16	to	to	IN
cord-006860-a3b8hyyr	1145	17	STA	STA	NNP
cord-006860-a3b8hyyr	1145	18	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	1145	19	system	system	NN
cord-006860-a3b8hyyr	1145	20	reagent	reagent	NN
cord-006860-a3b8hyyr	1145	21	.	.	.
cord-006860-a3b8hyyr	1146	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1146	2	allows	allow	VBZ
cord-006860-a3b8hyyr	1146	3	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	1146	4	monitoring	monitoring	NN
cord-006860-a3b8hyyr	1146	5	of	of	IN
cord-006860-a3b8hyyr	1146	6	high	high	JJ
cord-006860-a3b8hyyr	1146	7	dose	dose	NN
cord-006860-a3b8hyyr	1146	8	heparin	heparin	NN
cord-006860-a3b8hyyr	1146	9	therapy	therapy	NN
cord-006860-a3b8hyyr	1146	10	and	and	CC
cord-006860-a3b8hyyr	1146	11	is	be	VBZ
cord-006860-a3b8hyyr	1146	12	well	well	RB
cord-006860-a3b8hyyr	1146	13	suited	suited	JJ
cord-006860-a3b8hyyr	1146	14	for	for	IN
cord-006860-a3b8hyyr	1146	15	detecting	detect	VBG
cord-006860-a3b8hyyr	1146	16	abnormalities	abnormality	NNS
cord-006860-a3b8hyyr	1146	17	of	of	IN
cord-006860-a3b8hyyr	1146	18	the	the	DT
cord-006860-a3b8hyyr	1146	19	intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	1146	20	clotting	clotting	NN
cord-006860-a3b8hyyr	1146	21	factor	factor	NN
cord-006860-a3b8hyyr	1146	22	pathway	pathway	NN
cord-006860-a3b8hyyr	1146	23	.	.	.
cord-006860-a3b8hyyr	1147	1	is	be	VBZ
cord-006860-a3b8hyyr	1147	2	a	a	DT
cord-006860-a3b8hyyr	1147	3	standard	standard	JJ
cord-006860-a3b8hyyr	1147	4	technique	technique	NN
cord-006860-a3b8hyyr	1147	5	since	since	IN
cord-006860-a3b8hyyr	1147	6	many	many	JJ
cord-006860-a3b8hyyr	1147	7	years	year	NNS
cord-006860-a3b8hyyr	1147	8	.	.	.
cord-006860-a3b8hyyr	1148	1	The	the	DT
cord-006860-a3b8hyyr	1148	2	interpretation	interpretation	NN
cord-006860-a3b8hyyr	1148	3	of	of	IN
cord-006860-a3b8hyyr	1148	4	the	the	DT
cord-006860-a3b8hyyr	1148	5	thrombelastograms	thrombelastograms	NNP
cord-006860-a3b8hyyr	1148	6	has	have	VBZ
cord-006860-a3b8hyyr	1148	7	been	be	VBN
cord-006860-a3b8hyyr	1148	8	widely	widely	RB
cord-006860-a3b8hyyr	1148	9	based	base	VBN
cord-006860-a3b8hyyr	1148	10	on	on	IN
cord-006860-a3b8hyyr	1148	11	phenomenologic	phenomenologic	JJ
cord-006860-a3b8hyyr	1148	12	observations	observation	NNS
cord-006860-a3b8hyyr	1148	13	,	,	,
cord-006860-a3b8hyyr	1148	14	while	while	IN
cord-006860-a3b8hyyr	1148	15	there	there	EX
cord-006860-a3b8hyyr	1148	16	is	be	VBZ
cord-006860-a3b8hyyr	1148	17	a	a	DT
cord-006860-a3b8hyyr	1148	18	lack	lack	NN
cord-006860-a3b8hyyr	1148	19	of	of	IN
cord-006860-a3b8hyyr	1148	20	exact	exact	JJ
cord-006860-a3b8hyyr	1148	21	information	information	NN
cord-006860-a3b8hyyr	1148	22	concerning	concern	VBG
cord-006860-a3b8hyyr	1148	23	the	the	DT
cord-006860-a3b8hyyr	1148	24	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1148	25	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	1148	26	leading	lead	VBG
cord-006860-a3b8hyyr	1148	27	to	to	IN
cord-006860-a3b8hyyr	1148	28	the	the	DT
cord-006860-a3b8hyyr	1148	29	TEG	TEG	NNP
cord-006860-a3b8hyyr	1148	30	amplitude	amplitude	NN
cord-006860-a3b8hyyr	1148	31	(	(	-LRB-
cord-006860-a3b8hyyr	1148	32	A'rE~	A'rE~	NNP
cord-006860-a3b8hyyr	1148	33	)	)	-RRB-
cord-006860-a3b8hyyr	1148	34	.	.	.
cord-006860-a3b8hyyr	1149	1	The	the	DT
cord-006860-a3b8hyyr	1149	2	Aa'Ec	Aa'Ec	NNP
cord-006860-a3b8hyyr	1149	3	is	be	VBZ
cord-006860-a3b8hyyr	1149	4	a	a	DT
cord-006860-a3b8hyyr	1149	5	measure	measure	NN
cord-006860-a3b8hyyr	1149	6	for	for	IN
cord-006860-a3b8hyyr	1149	7	the	the	DT
cord-006860-a3b8hyyr	1149	8	mechanical	mechanical	JJ
cord-006860-a3b8hyyr	1149	9	stiffness	stiffness	NN
cord-006860-a3b8hyyr	1149	10	of	of	IN
cord-006860-a3b8hyyr	1149	11	the	the	DT
cord-006860-a3b8hyyr	1149	12	clot	clot	NN
cord-006860-a3b8hyyr	1149	13	and	and	CC
cord-006860-a3b8hyyr	1149	14	depends	depend	VBZ
cord-006860-a3b8hyyr	1149	15	on	on	IN
cord-006860-a3b8hyyr	1149	16	:	:	:
cord-006860-a3b8hyyr	1149	17	A	a	LS
cord-006860-a3b8hyyr	1149	18	)	)	-RRB-
cord-006860-a3b8hyyr	1149	19	Fibrin	fibrin	NN
cord-006860-a3b8hyyr	1149	20	formation	formation	NN
cord-006860-a3b8hyyr	1149	21	and	and	CC
cord-006860-a3b8hyyr	1149	22	adequate	adequate	JJ
cord-006860-a3b8hyyr	1149	23	polymerisatiun	polymerisatiun	NNS
cord-006860-a3b8hyyr	1149	24	of	of	IN
cord-006860-a3b8hyyr	1149	25	a	a	DT
cord-006860-a3b8hyyr	1149	26	3-dlmensional	3-dlmensional	CD
cord-006860-a3b8hyyr	1149	27	network	network	NN
cord-006860-a3b8hyyr	1149	28	:	:	:
cord-006860-a3b8hyyr	1149	29	measurements	measurement	NNS
cord-006860-a3b8hyyr	1149	30	with	with	IN
cord-006860-a3b8hyyr	1149	31	nonrecalcified	nonrecalcifie	VBN
cord-006860-a3b8hyyr	1149	32	citrated	citrated	JJ
cord-006860-a3b8hyyr	1149	33	blood	blood	NN
cord-006860-a3b8hyyr	1149	34	activated	activate	VBN
cord-006860-a3b8hyyr	1149	35	with	with	IN
cord-006860-a3b8hyyr	1149	36	ADP	ADP	NNP
cord-006860-a3b8hyyr	1149	37	or	or	CC
cord-006860-a3b8hyyr	1149	38	epinephrine	epinephrine	NN
cord-006860-a3b8hyyr	1149	39	(	(	-LRB-
cord-006860-a3b8hyyr	1149	40	both	both	DT
cord-006860-a3b8hyyr	1149	41	n=10	n=10	NNP
cord-006860-a3b8hyyr	1149	42	)	)	-RRB-
cord-006860-a3b8hyyr	1149	43	did	do	VBD
cord-006860-a3b8hyyr	1149	44	not	not	RB
cord-006860-a3b8hyyr	1149	45	show	show	VB
cord-006860-a3b8hyyr	1149	46	any	any	DT
cord-006860-a3b8hyyr	1149	47	clot	clot	NN
cord-006860-a3b8hyyr	1149	48	formation	formation	NN
cord-006860-a3b8hyyr	1149	49	in	in	IN
cord-006860-a3b8hyyr	1149	50	the	the	DT
cord-006860-a3b8hyyr	1149	51	TEG	TEG	NNP
cord-006860-a3b8hyyr	1150	1	This	this	DT
cord-006860-a3b8hyyr	1150	2	relies	rely	VBZ
cord-006860-a3b8hyyr	1150	3	on	on	IN
cord-006860-a3b8hyyr	1150	4	the	the	DT
cord-006860-a3b8hyyr	1150	5	need	need	NN
cord-006860-a3b8hyyr	1150	6	for	for	IN
cord-006860-a3b8hyyr	1150	7	a	a	DT
cord-006860-a3b8hyyr	1150	8	mechanical	mechanical	JJ
cord-006860-a3b8hyyr	1150	9	coupling	coupling	NN
cord-006860-a3b8hyyr	1150	10	between	between	IN
cord-006860-a3b8hyyr	1150	11	the	the	DT
cord-006860-a3b8hyyr	1150	12	TEG	TEG	NNP
cord-006860-a3b8hyyr	1150	13	pin	pin	NN
cord-006860-a3b8hyyr	1150	14	and	and	CC
cord-006860-a3b8hyyr	1150	15	cup	cup	VB
cord-006860-a3b8hyyr	1150	16	over	over	IN
cord-006860-a3b8hyyr	1150	17	a	a	DT
cord-006860-a3b8hyyr	1150	18	distance	distance	NN
cord-006860-a3b8hyyr	1150	19	of	of	IN
cord-006860-a3b8hyyr	1150	20	1	1	CD
cord-006860-a3b8hyyr	1150	21	mm	mm	NNS
cord-006860-a3b8hyyr	1150	22	,	,	,
cord-006860-a3b8hyyr	1150	23	which	which	WDT
cord-006860-a3b8hyyr	1150	24	is	be	VBZ
cord-006860-a3b8hyyr	1150	25	accomplished	accomplish	VBN
cord-006860-a3b8hyyr	1150	26	by	by	IN
cord-006860-a3b8hyyr	1150	27	the	the	DT
cord-006860-a3b8hyyr	1150	28	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1150	29	network	network	NN
cord-006860-a3b8hyyr	1151	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	1151	2	,	,	,
cord-006860-a3b8hyyr	1151	3	TEG	TEG	NNP
cord-006860-a3b8hyyr	1151	4	can	can	MD
cord-006860-a3b8hyyr	1151	5	only	only	RB
cord-006860-a3b8hyyr	1151	6	be	be	VB
cord-006860-a3b8hyyr	1151	7	performed	perform	VBN
cord-006860-a3b8hyyr	1151	8	under	under	IN
cord-006860-a3b8hyyr	1151	9	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1151	10	formation	formation	NN
cord-006860-a3b8hyyr	1151	11	and	and	CC
cord-006860-a3b8hyyr	1151	12	thus	thus	RB
cord-006860-a3b8hyyr	1151	13	under	under	IN
cord-006860-a3b8hyyr	1151	14	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1151	15	-	-	HYPH
cord-006860-a3b8hyyr	1151	16	activation	activation	NN
cord-006860-a3b8hyyr	1151	17	of	of	IN
cord-006860-a3b8hyyr	1151	18	the	the	DT
cord-006860-a3b8hyyr	1151	19	platelets	platelet	NNS
cord-006860-a3b8hyyr	1151	20	in	in	IN
cord-006860-a3b8hyyr	1151	21	the	the	DT
cord-006860-a3b8hyyr	1151	22	sample	sample	NN
cord-006860-a3b8hyyr	1151	23	.	.	.
cord-006860-a3b8hyyr	1152	1	Factors	factor	NNS
cord-006860-a3b8hyyr	1152	2	,	,	,
cord-006860-a3b8hyyr	1152	3	which	which	WDT
cord-006860-a3b8hyyr	1152	4	inhibit	inhibit	VBP
cord-006860-a3b8hyyr	1152	5	platelet	platelet	NN
cord-006860-a3b8hyyr	1152	6	aggregation	aggregation	NN
cord-006860-a3b8hyyr	1152	7	but	but	CC
cord-006860-a3b8hyyr	1152	8	do	do	VBP
cord-006860-a3b8hyyr	1152	9	n't	not	RB
cord-006860-a3b8hyyr	1152	10	limit	limit	VB
cord-006860-a3b8hyyr	1152	11	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1152	12	-	-	HYPH
cord-006860-a3b8hyyr	1152	13	activation	activation	NN
cord-006860-a3b8hyyr	1152	14	of	of	IN
cord-006860-a3b8hyyr	1152	15	platelets	platelet	NNS
cord-006860-a3b8hyyr	1152	16	,	,	,
cord-006860-a3b8hyyr	1152	17	can	can	MD
cord-006860-a3b8hyyr	1152	18	not	not	RB
cord-006860-a3b8hyyr	1152	19	be	be	VB
cord-006860-a3b8hyyr	1152	20	monitored	monitor	VBN
cord-006860-a3b8hyyr	1152	21	by	by	IN
cord-006860-a3b8hyyr	1152	22	TEG	TEG	NNP
cord-006860-a3b8hyyr	1152	23	.	.	.
cord-006860-a3b8hyyr	1153	1	B	b	NN
cord-006860-a3b8hyyr	1153	2	)	)	-RRB-
cord-006860-a3b8hyyr	1154	1	The	the	DT
cord-006860-a3b8hyyr	1154	2	attachment	attachment	NN
cord-006860-a3b8hyyr	1154	3	of	of	IN
cord-006860-a3b8hyyr	1154	4	the	the	DT
cord-006860-a3b8hyyr	1154	5	dot	dot	NN
cord-006860-a3b8hyyr	1154	6	on	on	IN
cord-006860-a3b8hyyr	1154	7	the	the	DT
cord-006860-a3b8hyyr	1154	8	surface	surface	NN
cord-006860-a3b8hyyr	1154	9	of	of	IN
cord-006860-a3b8hyyr	1154	10	the	the	DT
cord-006860-a3b8hyyr	1154	11	TEG	TEG	NNP
cord-006860-a3b8hyyr	1154	12	pin	pin	NNP
cord-006860-a3b8hyyr	1154	13	and	and	CC
cord-006860-a3b8hyyr	1154	14	cup	cup	NN
cord-006860-a3b8hyyr	1154	15	.	.	.
cord-006860-a3b8hyyr	1155	1	According	accord	VBG
cord-006860-a3b8hyyr	1155	2	to	to	IN
cord-006860-a3b8hyyr	1155	3	recent	recent	JJ
cord-006860-a3b8hyyr	1155	4	literature	literature	NN
cord-006860-a3b8hyyr	1155	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	1155	6	suggest	suggest	VBP
cord-006860-a3b8hyyr	1155	7	that	that	IN
cord-006860-a3b8hyyr	1155	8	the	the	DT
cord-006860-a3b8hyyr	1155	9	attachment	attachment	NN
cord-006860-a3b8hyyr	1155	10	of	of	IN
cord-006860-a3b8hyyr	1155	11	the	the	DT
cord-006860-a3b8hyyr	1155	12	clot	clot	NN
cord-006860-a3b8hyyr	1155	13	in	in	IN
cord-006860-a3b8hyyr	1155	14	the	the	DT
cord-006860-a3b8hyyr	1155	15	TEG	TEG	NNP
cord-006860-a3b8hyyr	1155	16	relies	rely	VBZ
cord-006860-a3b8hyyr	1155	17	exclusively	exclusively	RB
cord-006860-a3b8hyyr	1155	18	on	on	IN
cord-006860-a3b8hyyr	1155	19	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1155	20	/	/	SYM
cord-006860-a3b8hyyr	1155	21	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1155	22	adsorption	adsorption	NN
cord-006860-a3b8hyyr	1155	23	to	to	IN
cord-006860-a3b8hyyr	1155	24	the	the	DT
cord-006860-a3b8hyyr	1155	25	surfaces	surface	NNS
cord-006860-a3b8hyyr	1155	26	of	of	IN
cord-006860-a3b8hyyr	1155	27	the	the	DT
cord-006860-a3b8hyyr	1155	28	pin	pin	NN
cord-006860-a3b8hyyr	1155	29	and	and	CC
cord-006860-a3b8hyyr	1155	30	cup	cup	NN
cord-006860-a3b8hyyr	1155	31	.	.	.
cord-006860-a3b8hyyr	1156	1	Interruption	interruption	NN
cord-006860-a3b8hyyr	1156	2	of	of	IN
cord-006860-a3b8hyyr	1156	3	this	this	DT
cord-006860-a3b8hyyr	1156	4	attachment	attachment	NN
cord-006860-a3b8hyyr	1156	5	can	can	MD
cord-006860-a3b8hyyr	1156	6	result	result	VB
cord-006860-a3b8hyyr	1156	7	in	in	IN
cord-006860-a3b8hyyr	1156	8	lower	low	JJR
cord-006860-a3b8hyyr	1156	9	amplitudes	amplitude	NNS
cord-006860-a3b8hyyr	1156	10	or	or	CC
cord-006860-a3b8hyyr	1156	11	the	the	DT
cord-006860-a3b8hyyr	1156	12	so	so	RB
cord-006860-a3b8hyyr	1156	13	-	-	HYPH
cord-006860-a3b8hyyr	1156	14	called	call	VBN
cord-006860-a3b8hyyr	1156	15	,	,	,
cord-006860-a3b8hyyr	1156	16	,	,	,
cord-006860-a3b8hyyr	1156	17	stairway	stairway	NN
cord-006860-a3b8hyyr	1156	18	"	"	''
cord-006860-a3b8hyyr	1156	19	phenomenon	phenomenon	NN
cord-006860-a3b8hyyr	1156	20	.	.	.
cord-006860-a3b8hyyr	1157	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1157	2	could	could	MD
cord-006860-a3b8hyyr	1157	3	show	show	VB
cord-006860-a3b8hyyr	1157	4	a	a	DT
cord-006860-a3b8hyyr	1157	5	complete	complete	JJ
cord-006860-a3b8hyyr	1157	6	interruption	interruption	NN
cord-006860-a3b8hyyr	1157	7	of	of	IN
cord-006860-a3b8hyyr	1157	8	the	the	DT
cord-006860-a3b8hyyr	1157	9	clot	clot	NN
cord-006860-a3b8hyyr	1157	10	attachment	attachment	NN
cord-006860-a3b8hyyr	1157	11	by	by	IN
cord-006860-a3b8hyyr	1157	12	dipping	dip	VBG
cord-006860-a3b8hyyr	1157	13	the	the	DT
cord-006860-a3b8hyyr	1157	14	pin	pin	NN
cord-006860-a3b8hyyr	1157	15	for	for	IN
cord-006860-a3b8hyyr	1157	16	one	one	CD
cord-006860-a3b8hyyr	1157	17	second	second	NN
cord-006860-a3b8hyyr	1157	18	in	in	IN
cord-006860-a3b8hyyr	1157	19	30	30	CD
cord-006860-a3b8hyyr	1157	20	%	%	NN
cord-006860-a3b8hyyr	1157	21	albumine	albumine	NN
cord-006860-a3b8hyyr	1157	22	solution	solution	NN
cord-006860-a3b8hyyr	1157	23	(	(	-LRB-
cord-006860-a3b8hyyr	1157	24	n=10	n=10	NNP
cord-006860-a3b8hyyr	1157	25	)	)	-RRB-
cord-006860-a3b8hyyr	1157	26	.	.	.
cord-006860-a3b8hyyr	1158	1	C	C	NNP
cord-006860-a3b8hyyr	1158	2	)	)	-RRB-
cord-006860-a3b8hyyr	1159	1	The	the	DT
cord-006860-a3b8hyyr	1159	2	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1159	3	concentration	concentration	NN
cord-006860-a3b8hyyr	1159	4	(	(	-LRB-
cord-006860-a3b8hyyr	1159	5	Fg	Fg	NNP
cord-006860-a3b8hyyr	1159	6	)	)	-RRB-
cord-006860-a3b8hyyr	1159	7	and	and	CC
cord-006860-a3b8hyyr	1159	8	platelet	platelet	NN
cord-006860-a3b8hyyr	1159	9	count	count	NN
cord-006860-a3b8hyyr	1159	10	(	(	-LRB-
cord-006860-a3b8hyyr	1159	11	PC	pc	NN
cord-006860-a3b8hyyr	1159	12	)	)	-RRB-
cord-006860-a3b8hyyr	1159	13	of	of	IN
cord-006860-a3b8hyyr	1159	14	the	the	DT
cord-006860-a3b8hyyr	1159	15	sample	sample	NN
cord-006860-a3b8hyyr	1159	16	.	.	.
cord-006860-a3b8hyyr	1160	1	In	in	IN
cord-006860-a3b8hyyr	1160	2	50	50	CD
cord-006860-a3b8hyyr	1160	3	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	1160	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	1160	5	found	find	VBD
cord-006860-a3b8hyyr	1160	6	only	only	RB
cord-006860-a3b8hyyr	1160	7	a	a	DT
cord-006860-a3b8hyyr	1160	8	poor	poor	JJ
cord-006860-a3b8hyyr	1160	9	correlation	correlation	NN
cord-006860-a3b8hyyr	1160	10	of	of	IN
cord-006860-a3b8hyyr	1160	11	the	the	DT
cord-006860-a3b8hyyr	1160	12	maximum	maximum	JJ
cord-006860-a3b8hyyr	1160	13	amplitude	amplitude	NN
cord-006860-a3b8hyyr	1160	14	(	(	-LRB-
cord-006860-a3b8hyyr	1160	15	MA	MA	NNP
cord-006860-a3b8hyyr	1160	16	)	)	-RRB-
cord-006860-a3b8hyyr	1160	17	with	with	IN
cord-006860-a3b8hyyr	1160	18	Fg	Fg	NNP
cord-006860-a3b8hyyr	1160	19	alone	alone	JJ
cord-006860-a3b8hyyr	1160	20	(	(	-LRB-
cord-006860-a3b8hyyr	1160	21	r=0.40	r=0.40	NN
cord-006860-a3b8hyyr	1160	22	)	)	-RRB-
cord-006860-a3b8hyyr	1160	23	or	or	CC
cord-006860-a3b8hyyr	1160	24	PC	pc	NN
cord-006860-a3b8hyyr	1160	25	respectively	respectively	RB
cord-006860-a3b8hyyr	1160	26	(	(	-LRB-
cord-006860-a3b8hyyr	1160	27	r=0.50	r=0.50	NNP
cord-006860-a3b8hyyr	1160	28	)	)	-RRB-
cord-006860-a3b8hyyr	1160	29	,	,	,
cord-006860-a3b8hyyr	1160	30	while	while	IN
cord-006860-a3b8hyyr	1160	31	there	there	EX
cord-006860-a3b8hyyr	1160	32	was	be	VBD
cord-006860-a3b8hyyr	1160	33	a	a	DT
cord-006860-a3b8hyyr	1160	34	very	very	RB
cord-006860-a3b8hyyr	1160	35	good	good	JJ
cord-006860-a3b8hyyr	1160	36	nonlinear	nonlinear	JJ
cord-006860-a3b8hyyr	1160	37	correlation	correlation	NN
cord-006860-a3b8hyyr	1160	38	to	to	IN
cord-006860-a3b8hyyr	1160	39	the	the	DT
cord-006860-a3b8hyyr	1160	40	product	product	NN
cord-006860-a3b8hyyr	1160	41	of	of	IN
cord-006860-a3b8hyyr	1160	42	Fg	Fg	NNP
cord-006860-a3b8hyyr	1160	43	and	and	CC
cord-006860-a3b8hyyr	1160	44	PC	PC	NNP
cord-006860-a3b8hyyr	1160	45	.	.	.
cord-006860-a3b8hyyr	1161	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1161	2	suggest	suggest	VBP
cord-006860-a3b8hyyr	1161	3	that	that	IN
cord-006860-a3b8hyyr	1161	4	the	the	DT
cord-006860-a3b8hyyr	1161	5	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1161	6	network	network	NN
cord-006860-a3b8hyyr	1161	7	forms	form	VBZ
cord-006860-a3b8hyyr	1161	8	the	the	DT
cord-006860-a3b8hyyr	1161	9	main	main	JJ
cord-006860-a3b8hyyr	1161	10	structure	structure	NN
cord-006860-a3b8hyyr	1161	11	of	of	IN
cord-006860-a3b8hyyr	1161	12	the	the	DT
cord-006860-a3b8hyyr	1161	13	clot	clot	NN
cord-006860-a3b8hyyr	1161	14	while	while	IN
cord-006860-a3b8hyyr	1161	15	the	the	DT
cord-006860-a3b8hyyr	1161	16	thrombocytes	thrombocyte	NNS
cord-006860-a3b8hyyr	1161	17	enhance	enhance	VBP
cord-006860-a3b8hyyr	1161	18	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1161	19	stiffness	stiffness	NN
cord-006860-a3b8hyyr	1161	20	in	in	IN
cord-006860-a3b8hyyr	1161	21	a	a	DT
cord-006860-a3b8hyyr	1161	22	concentration	concentration	NN
cord-006860-a3b8hyyr	1161	23	-	-	HYPH
cord-006860-a3b8hyyr	1161	24	dependent	dependent	JJ
cord-006860-a3b8hyyr	1161	25	manner	manner	NN
cord-006860-a3b8hyyr	1161	26	.	.	.
cord-006860-a3b8hyyr	1162	1	This	this	DT
cord-006860-a3b8hyyr	1162	2	effect	effect	NN
cord-006860-a3b8hyyr	1162	3	of	of	IN
cord-006860-a3b8hyyr	1162	4	the	the	DT
cord-006860-a3b8hyyr	1162	5	ptatelets	ptatelet	NNS
cord-006860-a3b8hyyr	1162	6	can	can	MD
cord-006860-a3b8hyyr	1162	7	be	be	VB
cord-006860-a3b8hyyr	1162	8	completely	completely	RB
cord-006860-a3b8hyyr	1162	9	reversed	reverse	VBN
cord-006860-a3b8hyyr	1162	10	by	by	IN
cord-006860-a3b8hyyr	1162	11	GplIbfllla	GplIbfllla	NNP
cord-006860-a3b8hyyr	1162	12	antagonists	antagonist	NNS
cord-006860-a3b8hyyr	1162	13	.	.	.
cord-006860-a3b8hyyr	1163	1	D	D	NNP
cord-006860-a3b8hyyr	1163	2	)	)	-RRB-
cord-006860-a3b8hyyr	1164	1	Adequate	adequate	JJ
cord-006860-a3b8hyyr	1164	2	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1164	3	activation	activation	NN
cord-006860-a3b8hyyr	1164	4	:	:	:
cord-006860-a3b8hyyr	1164	5	In	in	IN
cord-006860-a3b8hyyr	1164	6	nonactivated	nonactivated	JJ
cord-006860-a3b8hyyr	1164	7	TEG	TEG	NNP
cord-006860-a3b8hyyr	1164	8	even	even	RB
cord-006860-a3b8hyyr	1164	9	small	small	JJ
cord-006860-a3b8hyyr	1164	10	amounts	amount	NNS
cord-006860-a3b8hyyr	1164	11	of	of	IN
cord-006860-a3b8hyyr	1164	12	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1164	13	can	can	MD
cord-006860-a3b8hyyr	1164	14	lead	lead	VB
cord-006860-a3b8hyyr	1164	15	to	to	IN
cord-006860-a3b8hyyr	1164	16	a	a	DT
cord-006860-a3b8hyyr	1164	17	significant	significant	JJ
cord-006860-a3b8hyyr	1164	18	reduction	reduction	NN
cord-006860-a3b8hyyr	1164	19	of	of	IN
cord-006860-a3b8hyyr	1164	20	the	the	DT
cord-006860-a3b8hyyr	1164	21	ATEG	ATEG	NNP
cord-006860-a3b8hyyr	1164	22	.	.	.
cord-006860-a3b8hyyr	1165	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	1165	2	:	:	:
cord-006860-a3b8hyyr	1166	1	Alterations	alteration	NNS
cord-006860-a3b8hyyr	1166	2	in	in	IN
cord-006860-a3b8hyyr	1166	3	TEG	TEG	NNP
cord-006860-a3b8hyyr	1166	4	measurements	measurement	NNS
cord-006860-a3b8hyyr	1166	5	can	can	MD
cord-006860-a3b8hyyr	1166	6	be	be	VB
cord-006860-a3b8hyyr	1166	7	judged	judge	VBN
cord-006860-a3b8hyyr	1166	8	more	more	RBR
cord-006860-a3b8hyyr	1166	9	properly	properly	RB
cord-006860-a3b8hyyr	1166	10	when	when	WRB
cord-006860-a3b8hyyr	1166	11	the	the	DT
cord-006860-a3b8hyyr	1166	12	underlying	underlie	VBG
cord-006860-a3b8hyyr	1166	13	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	1166	14	are	be	VBP
cord-006860-a3b8hyyr	1166	15	understood	understand	VBN
cord-006860-a3b8hyyr	1166	16	.	.	.
cord-006860-a3b8hyyr	1167	1	The	the	DT
cord-006860-a3b8hyyr	1167	2	consideration	consideration	NN
cord-006860-a3b8hyyr	1167	3	of	of	IN
cord-006860-a3b8hyyr	1167	4	the	the	DT
cord-006860-a3b8hyyr	1167	5	limitations	limitation	NNS
cord-006860-a3b8hyyr	1167	6	of	of	IN
cord-006860-a3b8hyyr	1167	7	the	the	DT
cord-006860-a3b8hyyr	1167	8	method	method	NN
cord-006860-a3b8hyyr	1167	9	allows	allow	VBZ
cord-006860-a3b8hyyr	1167	10	a	a	DT
cord-006860-a3b8hyyr	1167	11	more	more	RBR
cord-006860-a3b8hyyr	1167	12	specific	specific	JJ
cord-006860-a3b8hyyr	1167	13	interpretation	interpretation	NN
cord-006860-a3b8hyyr	1167	14	of	of	IN
cord-006860-a3b8hyyr	1167	15	the	the	DT
cord-006860-a3b8hyyr	1167	16	results	result	NNS
cord-006860-a3b8hyyr	1167	17	.	.	.
cord-006860-a3b8hyyr	1168	1	As	as	IN
cord-006860-a3b8hyyr	1168	2	a	a	DT
cord-006860-a3b8hyyr	1168	3	response	response	NN
cord-006860-a3b8hyyr	1168	4	on	on	IN
cord-006860-a3b8hyyr	1168	5	a	a	DT
cord-006860-a3b8hyyr	1168	6	customer	customer	NN
cord-006860-a3b8hyyr	1168	7	request	request	NN
cord-006860-a3b8hyyr	1168	8	we	-PRON-	PRP
cord-006860-a3b8hyyr	1168	9	did	do	VBD
cord-006860-a3b8hyyr	1168	10	investigate	investigate	VB
cord-006860-a3b8hyyr	1168	11	the	the	DT
cord-006860-a3b8hyyr	1168	12	sample	sample	NN
cord-006860-a3b8hyyr	1168	13	stability	stability	NN
cord-006860-a3b8hyyr	1168	14	of	of	IN
cord-006860-a3b8hyyr	1168	15	blood	blood	NN
cord-006860-a3b8hyyr	1168	16	samples	sample	NNS
cord-006860-a3b8hyyr	1168	17	for	for	IN
cord-006860-a3b8hyyr	1168	18	the	the	DT
cord-006860-a3b8hyyr	1168	19	aPTT	aptt	NN
cord-006860-a3b8hyyr	1168	20	.	.	.
cord-006860-a3b8hyyr	1169	1	The	the	DT
cord-006860-a3b8hyyr	1169	2	study	study	NN
cord-006860-a3b8hyyr	1169	3	was	be	VBD
cord-006860-a3b8hyyr	1169	4	set	set	VBN
cord-006860-a3b8hyyr	1169	5	up	up	RP
cord-006860-a3b8hyyr	1169	6	in	in	IN
cord-006860-a3b8hyyr	1169	7	a	a	DT
cord-006860-a3b8hyyr	1169	8	way	way	NN
cord-006860-a3b8hyyr	1169	9	that	that	WDT
cord-006860-a3b8hyyr	1169	10	simulated	simulate	VBD
cord-006860-a3b8hyyr	1169	11	the	the	DT
cord-006860-a3b8hyyr	1169	12	conditions	condition	NNS
cord-006860-a3b8hyyr	1169	13	of	of	IN
cord-006860-a3b8hyyr	1169	14	a	a	DT
cord-006860-a3b8hyyr	1169	15	large	large	JJ
cord-006860-a3b8hyyr	1169	16	private	private	JJ
cord-006860-a3b8hyyr	1169	17	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1169	18	in	in	IN
cord-006860-a3b8hyyr	1169	19	which	which	WDT
cord-006860-a3b8hyyr	1169	20	the	the	DT
cord-006860-a3b8hyyr	1169	21	samples	sample	NNS
cord-006860-a3b8hyyr	1169	22	arrive	arrive	VBP
cord-006860-a3b8hyyr	1169	23	several	several	JJ
cord-006860-a3b8hyyr	1169	24	hours	hour	NNS
cord-006860-a3b8hyyr	1169	25	after	after	IN
cord-006860-a3b8hyyr	1169	26	blood	blood	NN
cord-006860-a3b8hyyr	1169	27	collection	collection	NN
cord-006860-a3b8hyyr	1169	28	.	.	.
cord-006860-a3b8hyyr	1170	1	Blood	blood	NN
cord-006860-a3b8hyyr	1170	2	was	be	VBD
cord-006860-a3b8hyyr	1170	3	drawn	draw	VBN
cord-006860-a3b8hyyr	1170	4	from	from	IN
cord-006860-a3b8hyyr	1170	5	10	10	CD
cord-006860-a3b8hyyr	1170	6	donors	donor	NNS
cord-006860-a3b8hyyr	1170	7	into	into	IN
cord-006860-a3b8hyyr	1170	8	3.2	3.2	CD
cord-006860-a3b8hyyr	1170	9	%	%	NN
cord-006860-a3b8hyyr	1170	10	sodium	sodium	NN
cord-006860-a3b8hyyr	1170	11	citrate	citrate	NN
cord-006860-a3b8hyyr	1170	12	and	and	CC
cord-006860-a3b8hyyr	1170	13	mixed	mix	VBN
cord-006860-a3b8hyyr	1170	14	well	well	RB
cord-006860-a3b8hyyr	1170	15	before	before	IN
cord-006860-a3b8hyyr	1170	16	it	-PRON-	PRP
cord-006860-a3b8hyyr	1170	17	was	be	VBD
cord-006860-a3b8hyyr	1170	18	divided	divide	VBN
cord-006860-a3b8hyyr	1170	19	into	into	IN
cord-006860-a3b8hyyr	1170	20	several	several	JJ
cord-006860-a3b8hyyr	1170	21	aliquots	aliquot	NNS
cord-006860-a3b8hyyr	1170	22	Which	which	WDT
cord-006860-a3b8hyyr	1170	23	were	be	VBD
cord-006860-a3b8hyyr	1170	24	kept	keep	VBN
cord-006860-a3b8hyyr	1170	25	at	at	IN
cord-006860-a3b8hyyr	1170	26	room	room	NN
cord-006860-a3b8hyyr	1170	27	temperature	temperature	NN
cord-006860-a3b8hyyr	1170	28	.	.	.
cord-006860-a3b8hyyr	1171	1	The	the	DT
cord-006860-a3b8hyyr	1171	2	aliquots	aliquot	NNS
cord-006860-a3b8hyyr	1171	3	were	be	VBD
cord-006860-a3b8hyyr	1171	4	centrifuged	centrifuge	VBN
cord-006860-a3b8hyyr	1171	5	after	after	IN
cord-006860-a3b8hyyr	1171	6	~	~	CD
cord-006860-a3b8hyyr	1171	7	0,5	0,5	CD
cord-006860-a3b8hyyr	1171	8	,	,	,
cord-006860-a3b8hyyr	1171	9	11	11	CD
cord-006860-a3b8hyyr	1171	10	,	,	,
cord-006860-a3b8hyyr	1171	11	23	23	CD
cord-006860-a3b8hyyr	1171	12	and	and	CC
cord-006860-a3b8hyyr	1171	13	29	29	CD
cord-006860-a3b8hyyr	1171	14	h	h	NN
cord-006860-a3b8hyyr	1171	15	after	after	IN
cord-006860-a3b8hyyr	1171	16	venopuncture	venopuncture	NNP
cord-006860-a3b8hyyr	1171	17	and	and	CC
cord-006860-a3b8hyyr	1171	18	the	the	DT
cord-006860-a3b8hyyr	1171	19	plasma	plasma	NN
cord-006860-a3b8hyyr	1171	20	was	be	VBD
cord-006860-a3b8hyyr	1171	21	analyzed	analyze	VBN
cord-006860-a3b8hyyr	1171	22	immediately	immediately	RB
cord-006860-a3b8hyyr	1171	23	with	with	IN
cord-006860-a3b8hyyr	1171	24	3	3	CD
cord-006860-a3b8hyyr	1171	25	different	different	JJ
cord-006860-a3b8hyyr	1171	26	reagents	reagent	NNS
cord-006860-a3b8hyyr	1171	27	on	on	IN
cord-006860-a3b8hyyr	1171	28	Electra	Electra	NNP
cord-006860-a3b8hyyr	1171	29	1000	1000	CD
cord-006860-a3b8hyyr	1171	30	.	.	.
cord-006860-a3b8hyyr	1172	1	Results	result	NNS
cord-006860-a3b8hyyr	1172	2	:	:	:
cord-006860-a3b8hyyr	1173	1	There	there	EX
cord-006860-a3b8hyyr	1173	2	was	be	VBD
cord-006860-a3b8hyyr	1173	3	a	a	DT
cord-006860-a3b8hyyr	1173	4	clear	clear	JJ
cord-006860-a3b8hyyr	1173	5	difference	difference	NN
cord-006860-a3b8hyyr	1173	6	in	in	IN
cord-006860-a3b8hyyr	1173	7	the	the	DT
cord-006860-a3b8hyyr	1173	8	change	change	NN
cord-006860-a3b8hyyr	1173	9	of	of	IN
cord-006860-a3b8hyyr	1173	10	the	the	DT
cord-006860-a3b8hyyr	1173	11	aPTTover	aPTTover	NNP
cord-006860-a3b8hyyr	1173	12	time	time	NN
cord-006860-a3b8hyyr	1173	13	with	with	IN
cord-006860-a3b8hyyr	1173	14	these	these	DT
cord-006860-a3b8hyyr	1173	15	reagents	reagent	NNS
cord-006860-a3b8hyyr	1173	16	.	.	.
cord-006860-a3b8hyyr	1174	1	Also	also	RB
cord-006860-a3b8hyyr	1174	2	F	F	NNP
cord-006860-a3b8hyyr	1174	3	VIII	VIII	NNP
cord-006860-a3b8hyyr	1174	4	(	(	-LRB-
cord-006860-a3b8hyyr	1174	5	determined	determine	VBN
cord-006860-a3b8hyyr	1174	6	with	with	IN
cord-006860-a3b8hyyr	1174	7	a	a	DT
cord-006860-a3b8hyyr	1174	8	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	1174	9	assay	assay	NN
cord-006860-a3b8hyyr	1174	10	with	with	IN
cord-006860-a3b8hyyr	1174	11	complete	complete	JJ
cord-006860-a3b8hyyr	1174	12	and	and	CC
cord-006860-a3b8hyyr	1174	13	standardized	standardized	JJ
cord-006860-a3b8hyyr	1174	14	activation	activation	NN
cord-006860-a3b8hyyr	1174	15	)	)	-RRB-
cord-006860-a3b8hyyr	1174	16	change	change	NN
cord-006860-a3b8hyyr	1174	17	considerably	considerably	RB
cord-006860-a3b8hyyr	1174	18	.	.	.
cord-006860-a3b8hyyr	1175	1	2	2	LS
cord-006860-a3b8hyyr	1175	2	Reagent	Reagent	NNP
cord-006860-a3b8hyyr	1175	3	A	a	NN
cord-006860-a3b8hyyr	1175	4	:	:	:
cord-006860-a3b8hyyr	1175	5	ellagic	ellagic	JJ
cord-006860-a3b8hyyr	1175	6	acid	acid	NN
cord-006860-a3b8hyyr	1175	7	,	,	,
cord-006860-a3b8hyyr	1175	8	plant	plant	NN
cord-006860-a3b8hyyr	1175	9	phospholipid	phospholipid	NN
cord-006860-a3b8hyyr	1175	10	,	,	,
cord-006860-a3b8hyyr	1175	11	reagent	reagent	NN
cord-006860-a3b8hyyr	1175	12	B	b	NN
cord-006860-a3b8hyyr	1175	13	:	:	:
cord-006860-a3b8hyyr	1175	14	sulfatide	sulfatide	NN
cord-006860-a3b8hyyr	1175	15	/	/	SYM
cord-006860-a3b8hyyr	1175	16	kaolin	kaolin	NN
cord-006860-a3b8hyyr	1175	17	,	,	,
cord-006860-a3b8hyyr	1175	18	phopholipids	phopholipids	NNP
cord-006860-a3b8hyyr	1175	19	,	,	,
cord-006860-a3b8hyyr	1175	20	reagent	reagent	NN
cord-006860-a3b8hyyr	1175	21	C	c	NN
cord-006860-a3b8hyyr	1175	22	:	:	:
cord-006860-a3b8hyyr	1176	1	¢llagi¢	¢llagi¢	DT
cord-006860-a3b8hyyr	1176	2	acid	acid	NN
cord-006860-a3b8hyyr	1176	3	,	,	,
cord-006860-a3b8hyyr	1176	4	plant	plant	NN
cord-006860-a3b8hyyr	1176	5	and	and	CC
cord-006860-a3b8hyyr	1176	6	rabbit	rabbit	NN
cord-006860-a3b8hyyr	1176	7	brain	brain	NN
cord-006860-a3b8hyyr	1176	8	phospholipids	phospholipid	NNS
cord-006860-a3b8hyyr	1177	1	The	the	DT
cord-006860-a3b8hyyr	1177	2	increase	increase	NN
cord-006860-a3b8hyyr	1177	3	of	of	IN
cord-006860-a3b8hyyr	1177	4	aPTT	aptt	NN
cord-006860-a3b8hyyr	1177	5	was	be	VBD
cord-006860-a3b8hyyr	1177	6	apparently	apparently	RB
cord-006860-a3b8hyyr	1177	7	not	not	RB
cord-006860-a3b8hyyr	1177	8	a	a	DT
cord-006860-a3b8hyyr	1177	9	function	function	NN
cord-006860-a3b8hyyr	1177	10	of	of	IN
cord-006860-a3b8hyyr	1177	11	the	the	DT
cord-006860-a3b8hyyr	1177	12	decrease	decrease	NN
cord-006860-a3b8hyyr	1177	13	of	of	IN
cord-006860-a3b8hyyr	1177	14	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	1177	15	because	because	IN
cord-006860-a3b8hyyr	1177	16	the	the	DT
cord-006860-a3b8hyyr	1177	17	in	in	FW
cord-006860-a3b8hyyr	1177	18	vitro	vitro	FW
cord-006860-a3b8hyyr	1177	19	F	f	NN
cord-006860-a3b8hyyr	1177	20	VIII	VIII	NNP
cord-006860-a3b8hyyr	1177	21	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	1177	22	of	of	IN
cord-006860-a3b8hyyr	1177	23	reagent	reagent	NN
cord-006860-a3b8hyyr	1177	24	B.	B.	NNP
cord-006860-a3b8hyyr	1177	25	was	be	VBD
cord-006860-a3b8hyyr	1177	26	inferior	inferior	JJ
cord-006860-a3b8hyyr	1177	27	to	to	TO
cord-006860-a3b8hyyr	1177	28	reagent	reagent	VB
cord-006860-a3b8hyyr	1177	29	A	a	DT
cord-006860-a3b8hyyr	1177	30	though	though	IN
cord-006860-a3b8hyyr	1177	31	reagent	reagent	NN
cord-006860-a3b8hyyr	1177	32	B	b	NN
cord-006860-a3b8hyyr	1177	33	showed	show	VBD
cord-006860-a3b8hyyr	1177	34	more	more	JJR
cord-006860-a3b8hyyr	1177	35	prolongation	prolongation	NN
cord-006860-a3b8hyyr	1177	36	of	of	IN
cord-006860-a3b8hyyr	1177	37	the	the	DT
cord-006860-a3b8hyyr	1177	38	aPTT	aptt	NN
cord-006860-a3b8hyyr	1177	39	than	than	IN
cord-006860-a3b8hyyr	1177	40	reagent	reagent	NN
cord-006860-a3b8hyyr	1177	41	A.	a.	NN
cord-006860-a3b8hyyr	1177	42	Reagent	Reagent	NNP
cord-006860-a3b8hyyr	1177	43	C	C	NNP
cord-006860-a3b8hyyr	1177	44	,	,	,
cord-006860-a3b8hyyr	1177	45	however	however	RB
cord-006860-a3b8hyyr	1177	46	,	,	,
cord-006860-a3b8hyyr	1177	47	showed	show	VBD
cord-006860-a3b8hyyr	1177	48	only	only	RB
cord-006860-a3b8hyyr	1177	49	minor	minor	JJ
cord-006860-a3b8hyyr	1177	50	changes	change	NNS
cord-006860-a3b8hyyr	1177	51	in	in	IN
cord-006860-a3b8hyyr	1177	52	the	the	DT
cord-006860-a3b8hyyr	1177	53	aPTT	aptt	NN
cord-006860-a3b8hyyr	1177	54	.	.	.
cord-006860-a3b8hyyr	1178	1	Discussion	discussion	NN
cord-006860-a3b8hyyr	1178	2	:	:	:
cord-006860-a3b8hyyr	1179	1	These	these	DT
cord-006860-a3b8hyyr	1179	2	data	datum	NNS
cord-006860-a3b8hyyr	1179	3	show	show	VBP
cord-006860-a3b8hyyr	1179	4	that	that	IN
cord-006860-a3b8hyyr	1179	5	the	the	DT
cord-006860-a3b8hyyr	1179	6	sample	sample	NN
cord-006860-a3b8hyyr	1179	7	stabifity	stabifity	NN
cord-006860-a3b8hyyr	1179	8	of	of	IN
cord-006860-a3b8hyyr	1179	9	the	the	DT
cord-006860-a3b8hyyr	1179	10	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	1179	11	is	be	VBZ
cord-006860-a3b8hyyr	1179	12	reagent	reagent	JJ
cord-006860-a3b8hyyr	1179	13	dependent	dependent	JJ
cord-006860-a3b8hyyr	1179	14	and	and	CC
cord-006860-a3b8hyyr	1179	15	that	that	IN
cord-006860-a3b8hyyr	1179	16	it	-PRON-	PRP
cord-006860-a3b8hyyr	1179	17	is	be	VBZ
cord-006860-a3b8hyyr	1179	18	not	not	RB
cord-006860-a3b8hyyr	1179	19	simply	simply	RB
cord-006860-a3b8hyyr	1179	20	a	a	DT
cord-006860-a3b8hyyr	1179	21	function	function	NN
cord-006860-a3b8hyyr	1179	22	off	off	IN
cord-006860-a3b8hyyr	1179	23	VIII	VIII	NNP
cord-006860-a3b8hyyr	1179	24	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	1179	25	.	.	.
cord-006860-a3b8hyyr	1180	1	Other	other	JJ
cord-006860-a3b8hyyr	1180	2	factors	factor	NNS
cord-006860-a3b8hyyr	1180	3	such	such	JJ
cord-006860-a3b8hyyr	1180	4	as	as	IN
cord-006860-a3b8hyyr	1180	5	the	the	DT
cord-006860-a3b8hyyr	1180	6	buffer	buffer	NN
cord-006860-a3b8hyyr	1180	7	system	system	NN
cord-006860-a3b8hyyr	1180	8	but	but	CC
cord-006860-a3b8hyyr	1180	9	also	also	RB
cord-006860-a3b8hyyr	1180	10	the	the	DT
cord-006860-a3b8hyyr	1180	11	sensitivitiy	sensitivitiy	NNS
cord-006860-a3b8hyyr	1180	12	towards	towards	IN
cord-006860-a3b8hyyr	1180	13	other	other	JJ
cord-006860-a3b8hyyr	1180	14	factors	factor	NNS
cord-006860-a3b8hyyr	1180	15	than	than	IN
cord-006860-a3b8hyyr	1180	16	F	F	NNP
cord-006860-a3b8hyyr	1180	17	VIII	VIII	NNP
cord-006860-a3b8hyyr	1180	18	seem	seem	VBP
cord-006860-a3b8hyyr	1180	19	to	to	TO
cord-006860-a3b8hyyr	1180	20	contribute	contribute	VB
cord-006860-a3b8hyyr	1180	21	.	.	.
cord-006860-a3b8hyyr	1181	1	A	a	DT
cord-006860-a3b8hyyr	1181	2	COMPARISON	comparison	NN
cord-006860-a3b8hyyr	1181	3	OF	of	IN
cord-006860-a3b8hyyr	1181	4	THE	the	DT
cord-006860-a3b8hyyr	1181	5	TECHNICAL	TECHNICAL	NNP
cord-006860-a3b8hyyr	1181	6	PRINCIPLE	PRINCIPLE	NNP
cord-006860-a3b8hyyr	1181	7	OF	of	IN
cord-006860-a3b8hyyr	1181	8	THE	the	DT
cord-006860-a3b8hyyr	1181	9	roTEG	roteg	DT
cord-006860-a3b8hyyr	1181	10	COAGULATION	coagulation	NN
cord-006860-a3b8hyyr	1181	11	ANALYSER	ANALYSER	NNP
cord-006860-a3b8hyyr	1181	12	AND	and	CC
cord-006860-a3b8hyyr	1181	13	CONVENTIONAL	CONVENTIONAL	NNP
cord-006860-a3b8hyyr	1182	1	THROMBELASTOGRAPHIC	THROMBELASTOGRAPHIC	NNP
cord-006860-a3b8hyyr	1182	2	SYSTEMS	SYSTEMS	NNP
cord-006860-a3b8hyyr	1182	3	An	An	NNP
cord-006860-a3b8hyyr	1182	4	.	.	.
cord-006860-a3b8hyyr	1183	1	Calatzis	Calatzis	NNP
cord-006860-a3b8hyyr	1183	2	,	,	,
cord-006860-a3b8hyyr	1183	3	P.	P.	NNP
cord-006860-a3b8hyyr	1183	4	Fritzsche	Fritzsche	NNP
cord-006860-a3b8hyyr	1183	5	.	.	.
cord-006860-a3b8hyyr	1184	1	AL	AL	NNP
cord-006860-a3b8hyyr	1184	2	Calatzis	Calatzis	NNP
cord-006860-a3b8hyyr	1184	3	,	,	,
cord-006860-a3b8hyyr	1184	4	+	+	CC
cord-006860-a3b8hyyr	1184	5	M.	M.	NNP
cord-006860-a3b8hyyr	1184	6	Kling	Kling	NNP
cord-006860-a3b8hyyr	1184	7	,	,	,
cord-006860-a3b8hyyr	1184	8	+	+	CC
cord-006860-a3b8hyyr	1184	9	R.	R.	NNP
cord-006860-a3b8hyyr	1184	10	Hipp	Hipp	NNP
cord-006860-a3b8hyyr	1184	11	,	,	,
cord-006860-a3b8hyyr	1184	12	A.	A.	NNP
cord-006860-a3b8hyyr	1184	13	Stemberger	Stemberger	NNP
cord-006860-a3b8hyyr	1184	14	Institute	Institute	NNP
cord-006860-a3b8hyyr	1184	15	for	for	IN
cord-006860-a3b8hyyr	1184	16	Experimental	Experimental	NNP
cord-006860-a3b8hyyr	1184	17	Surgery	Surgery	NNP
cord-006860-a3b8hyyr	1184	18	and	and	CC
cord-006860-a3b8hyyr	1185	1	+	+	CC
cord-006860-a3b8hyyr	1185	2	Institute	Institute	NNP
cord-006860-a3b8hyyr	1185	3	of	of	IN
cord-006860-a3b8hyyr	1185	4	Anesthesiology	Anesthesiology	NNP
cord-006860-a3b8hyyr	1185	5	Yechnische	Yechnische	NNP
cord-006860-a3b8hyyr	1185	6	Universit	Universit	NNP
cord-006860-a3b8hyyr	1186	1	~	~	NFP
cord-006860-a3b8hyyr	1187	1	t	t	NNP
cord-006860-a3b8hyyr	1187	2	M0nchen	M0nchen	NNP
cord-006860-a3b8hyyr	1187	3	Thrombelastography	Thrombelastography	NNP
cord-006860-a3b8hyyr	1187	4	(	(	-LRB-
cord-006860-a3b8hyyr	1187	5	TEG	TEG	NNP
cord-006860-a3b8hyyr	1187	6	)	)	-RRB-
cord-006860-a3b8hyyr	1187	7	was	be	VBD
cord-006860-a3b8hyyr	1187	8	introduced	introduce	VBN
cord-006860-a3b8hyyr	1187	9	by	by	IN
cord-006860-a3b8hyyr	1187	10	Hartert	Hartert	NNP
cord-006860-a3b8hyyr	1187	11	in	in	IN
cord-006860-a3b8hyyr	1187	12	1948	1948	CD
cord-006860-a3b8hyyr	1187	13	as	as	IN
cord-006860-a3b8hyyr	1187	14	a	a	DT
cord-006860-a3b8hyyr	1187	15	method	method	NN
cord-006860-a3b8hyyr	1187	16	for	for	IN
cord-006860-a3b8hyyr	1187	17	continous	continous	JJ
cord-006860-a3b8hyyr	1187	18	registration	registration	NN
cord-006860-a3b8hyyr	1187	19	of	of	IN
cord-006860-a3b8hyyr	1187	20	the	the	DT
cord-006860-a3b8hyyr	1187	21	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1187	22	process	process	NN
cord-006860-a3b8hyyr	1187	23	.	.	.
cord-006860-a3b8hyyr	1188	1	In	in	IN
cord-006860-a3b8hyyr	1188	2	1995	1995	CD
cord-006860-a3b8hyyr	1188	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	1188	4	presented	present	VBD
cord-006860-a3b8hyyr	1188	5	the	the	DT
cord-006860-a3b8hyyr	1188	6	roTEG	roTEG	NNP
cord-006860-a3b8hyyr	1188	7	Coagulation	coagulation	NN
cord-006860-a3b8hyyr	1188	8	Analyser	Analyser	NNP
cord-006860-a3b8hyyr	1188	9	,	,	,
cord-006860-a3b8hyyr	1188	10	using	use	VBG
cord-006860-a3b8hyyr	1188	11	a	a	DT
cord-006860-a3b8hyyr	1188	12	newly	newly	RB
cord-006860-a3b8hyyr	1188	13	developed	develop	VBN
cord-006860-a3b8hyyr	1188	14	technical	technical	JJ
cord-006860-a3b8hyyr	1188	15	method	method	NN
cord-006860-a3b8hyyr	1188	16	.	.	.
cord-006860-a3b8hyyr	1189	1	In	in	IN
cord-006860-a3b8hyyr	1189	2	TEG	TEG	NNP
cord-006860-a3b8hyyr	1189	3	systems	system	NNS
cord-006860-a3b8hyyr	1189	4	according	accord	VBG
cord-006860-a3b8hyyr	1189	5	to	to	IN
cord-006860-a3b8hyyr	1189	6	I	-PRON-	PRP
cord-006860-a3b8hyyr	1190	1	/artert	/artert	.
cord-006860-a3b8hyyr	1191	1	the	the	DT
cord-006860-a3b8hyyr	1191	2	sample	sample	NN
cord-006860-a3b8hyyr	1191	3	(	(	-LRB-
cord-006860-a3b8hyyr	1191	4	blood	blood	NN
cord-006860-a3b8hyyr	1191	5	or	or	CC
cord-006860-a3b8hyyr	1191	6	plasma	plasma	NN
cord-006860-a3b8hyyr	1191	7	)	)	-RRB-
cord-006860-a3b8hyyr	1191	8	is	be	VBZ
cord-006860-a3b8hyyr	1191	9	placed	place	VBN
cord-006860-a3b8hyyr	1191	10	in	in	IN
cord-006860-a3b8hyyr	1191	11	a	a	DT
cord-006860-a3b8hyyr	1191	12	cup	cup	NN
cord-006860-a3b8hyyr	1191	13	which	which	WDT
cord-006860-a3b8hyyr	1191	14	is	be	VBZ
cord-006860-a3b8hyyr	1191	15	alternately	alternately	RB
cord-006860-a3b8hyyr	1191	16	rotated	rotate	VBN
cord-006860-a3b8hyyr	1191	17	to	to	IN
cord-006860-a3b8hyyr	1191	18	the	the	DT
cord-006860-a3b8hyyr	1191	19	right	right	NN
cord-006860-a3b8hyyr	1191	20	and	and	CC
cord-006860-a3b8hyyr	1191	21	left	leave	VBN
cord-006860-a3b8hyyr	1191	22	by	by	IN
cord-006860-a3b8hyyr	1191	23	4,75	4,75	CD
cord-006860-a3b8hyyr	1191	24	°	°	NNS
cord-006860-a3b8hyyr	1191	25	.	.	.
cord-006860-a3b8hyyr	1192	1	A	a	DT
cord-006860-a3b8hyyr	1192	2	cylindrical	cylindrical	JJ
cord-006860-a3b8hyyr	1192	3	pin	pin	NN
cord-006860-a3b8hyyr	1192	4	,	,	,
cord-006860-a3b8hyyr	1192	5	which	which	WDT
cord-006860-a3b8hyyr	1192	6	is	be	VBZ
cord-006860-a3b8hyyr	1192	7	suspended	suspend	VBN
cord-006860-a3b8hyyr	1192	8	freely	freely	RB
cord-006860-a3b8hyyr	1192	9	on	on	IN
cord-006860-a3b8hyyr	1192	10	a	a	DT
cord-006860-a3b8hyyr	1192	11	torsion	torsion	NN
cord-006860-a3b8hyyr	1192	12	wire	wire	NN
cord-006860-a3b8hyyr	1192	13	,	,	,
cord-006860-a3b8hyyr	1192	14	is	be	VBZ
cord-006860-a3b8hyyr	1192	15	lowered	lower	VBN
cord-006860-a3b8hyyr	1192	16	into	into	IN
cord-006860-a3b8hyyr	1192	17	the	the	DT
cord-006860-a3b8hyyr	1192	18	blood	blood	NN
cord-006860-a3b8hyyr	1192	19	.	.	.
cord-006860-a3b8hyyr	1193	1	When	when	WRB
cord-006860-a3b8hyyr	1193	2	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1193	3	starts	start	VBZ
cord-006860-a3b8hyyr	1193	4	,	,	,
cord-006860-a3b8hyyr	1193	5	the	the	DT
cord-006860-a3b8hyyr	1193	6	clot	clot	NN
cord-006860-a3b8hyyr	1193	7	begins	begin	VBZ
cord-006860-a3b8hyyr	1193	8	to	to	TO
cord-006860-a3b8hyyr	1193	9	transfer	transfer	VB
cord-006860-a3b8hyyr	1193	10	the	the	DT
cord-006860-a3b8hyyr	1193	11	rotation	rotation	NN
cord-006860-a3b8hyyr	1193	12	of	of	IN
cord-006860-a3b8hyyr	1193	13	the	the	DT
cord-006860-a3b8hyyr	1193	14	cup	cup	NN
cord-006860-a3b8hyyr	1193	15	to	to	IN
cord-006860-a3b8hyyr	1193	16	the	the	DT
cord-006860-a3b8hyyr	1193	17	pin	pin	NN
cord-006860-a3b8hyyr	1193	18	against	against	IN
cord-006860-a3b8hyyr	1193	19	the	the	DT
cord-006860-a3b8hyyr	1193	20	reverse	reverse	JJ
cord-006860-a3b8hyyr	1193	21	momentum	momentum	NN
cord-006860-a3b8hyyr	1193	22	of	of	IN
cord-006860-a3b8hyyr	1193	23	the	the	DT
cord-006860-a3b8hyyr	1193	24	torsion	torsion	NN
cord-006860-a3b8hyyr	1193	25	wire	wire	NN
cord-006860-a3b8hyyr	1193	26	.	.	.
cord-006860-a3b8hyyr	1194	1	The	the	DT
cord-006860-a3b8hyyr	1194	2	angle	angle	NN
cord-006860-a3b8hyyr	1194	3	of	of	IN
cord-006860-a3b8hyyr	1194	4	the	the	DT
cord-006860-a3b8hyyr	1194	5	pin	pin	NN
cord-006860-a3b8hyyr	1194	6	is	be	VBZ
cord-006860-a3b8hyyr	1194	7	electromagnetically	electromagnetically	RB
cord-006860-a3b8hyyr	1194	8	detected	detect	VBN
cord-006860-a3b8hyyr	1194	9	,	,	,
cord-006860-a3b8hyyr	1194	10	transformed	transform	VBN
cord-006860-a3b8hyyr	1194	11	to	to	IN
cord-006860-a3b8hyyr	1194	12	the	the	DT
cord-006860-a3b8hyyr	1194	13	TEG	TEG	NNP
cord-006860-a3b8hyyr	1194	14	amplitude	amplitude	NN
cord-006860-a3b8hyyr	1194	15	and	and	CC
cord-006860-a3b8hyyr	1194	16	continously	continously	RB
cord-006860-a3b8hyyr	1194	17	recorded	record	VBN
cord-006860-a3b8hyyr	1194	18	.	.	.
cord-006860-a3b8hyyr	1195	1	In	in	IN
cord-006860-a3b8hyyr	1195	2	the	the	DT
cord-006860-a3b8hyyr	1195	3	roTEG	roteg	XX
cord-006860-a3b8hyyr	1195	4	the	the	DT
cord-006860-a3b8hyyr	1195	5	pin	pin	NN
cord-006860-a3b8hyyr	1195	6	is	be	VBZ
cord-006860-a3b8hyyr	1195	7	attached	attach	VBN
cord-006860-a3b8hyyr	1195	8	to	to	IN
cord-006860-a3b8hyyr	1195	9	a	a	DT
cord-006860-a3b8hyyr	1195	10	short	short	JJ
cord-006860-a3b8hyyr	1195	11	axis	axis	NN
cord-006860-a3b8hyyr	1195	12	,	,	,
cord-006860-a3b8hyyr	1195	13	which	which	WDT
cord-006860-a3b8hyyr	1195	14	is	be	VBZ
cord-006860-a3b8hyyr	1195	15	guided	guide	VBN
cord-006860-a3b8hyyr	1195	16	by	by	IN
cord-006860-a3b8hyyr	1195	17	a	a	DT
cord-006860-a3b8hyyr	1195	18	ball	ball	NN
cord-006860-a3b8hyyr	1195	19	beating	beating	NN
cord-006860-a3b8hyyr	1195	20	.	.	.
cord-006860-a3b8hyyr	1196	1	Thus	thus	RB
cord-006860-a3b8hyyr	1196	2	all	all	DT
cord-006860-a3b8hyyr	1196	3	possible	possible	JJ
cord-006860-a3b8hyyr	1196	4	movement	movement	NN
cord-006860-a3b8hyyr	1196	5	is	be	VBZ
cord-006860-a3b8hyyr	1196	6	limited	limit	VBN
cord-006860-a3b8hyyr	1196	7	to	to	IN
cord-006860-a3b8hyyr	1196	8	rpotation	rpotation	NN
cord-006860-a3b8hyyr	1196	9	(	(	-LRB-
cord-006860-a3b8hyyr	1196	10	r_oTEG	r_oteg	NN
cord-006860-a3b8hyyr	1196	11	)	)	-RRB-
cord-006860-a3b8hyyr	1196	12	.	.	.
cord-006860-a3b8hyyr	1197	1	The	the	DT
cord-006860-a3b8hyyr	1197	2	cup	cup	NN
cord-006860-a3b8hyyr	1197	3	is	be	VBZ
cord-006860-a3b8hyyr	1197	4	stationary	stationary	JJ
cord-006860-a3b8hyyr	1197	5	,	,	,
cord-006860-a3b8hyyr	1197	6	and	and	CC
cord-006860-a3b8hyyr	1197	7	the	the	DT
cord-006860-a3b8hyyr	1197	8	pin	pin	NN
cord-006860-a3b8hyyr	1197	9	is	be	VBZ
cord-006860-a3b8hyyr	1197	10	rotated	rotate	VBN
cord-006860-a3b8hyyr	1197	11	alternately	alternately	RB
cord-006860-a3b8hyyr	1197	12	by	by	IN
cord-006860-a3b8hyyr	1197	13	5	5	CD
cord-006860-a3b8hyyr	1197	14	°	°	NNS
cord-006860-a3b8hyyr	1197	15	to	to	IN
cord-006860-a3b8hyyr	1197	16	the	the	DT
cord-006860-a3b8hyyr	1197	17	right	right	NN
cord-006860-a3b8hyyr	1197	18	and	and	CC
cord-006860-a3b8hyyr	1197	19	left	leave	VBN
cord-006860-a3b8hyyr	1197	20	by	by	IN
cord-006860-a3b8hyyr	1197	21	a	a	DT
cord-006860-a3b8hyyr	1197	22	feather	feather	NN
cord-006860-a3b8hyyr	1197	23	system	system	NN
cord-006860-a3b8hyyr	1197	24	.	.	.
cord-006860-a3b8hyyr	1198	1	When	when	WRB
cord-006860-a3b8hyyr	1198	2	a	a	DT
cord-006860-a3b8hyyr	1198	3	clot	clot	NN
cord-006860-a3b8hyyr	1198	4	is	be	VBZ
cord-006860-a3b8hyyr	1198	5	formed	form	VBN
cord-006860-a3b8hyyr	1198	6	,	,	,
cord-006860-a3b8hyyr	1198	7	it	-PRON-	PRP
cord-006860-a3b8hyyr	1198	8	attaches	attach	VBZ
cord-006860-a3b8hyyr	1198	9	to	to	IN
cord-006860-a3b8hyyr	1198	10	the	the	DT
cord-006860-a3b8hyyr	1198	11	surfaces	surface	NNS
cord-006860-a3b8hyyr	1198	12	of	of	IN
cord-006860-a3b8hyyr	1198	13	the	the	DT
cord-006860-a3b8hyyr	1198	14	pin	pin	NN
cord-006860-a3b8hyyr	1198	15	and	and	CC
cord-006860-a3b8hyyr	1198	16	cup	cup	NN
cord-006860-a3b8hyyr	1198	17	and	and	CC
cord-006860-a3b8hyyr	1198	18	starts	start	VBZ
cord-006860-a3b8hyyr	1198	19	preventing	prevent	VBG
cord-006860-a3b8hyyr	1198	20	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1198	21	relative	relative	JJ
cord-006860-a3b8hyyr	1198	22	movements	movement	NNS
cord-006860-a3b8hyyr	1198	23	against	against	IN
cord-006860-a3b8hyyr	1198	24	the	the	DT
cord-006860-a3b8hyyr	1198	25	reverse	reverse	JJ
cord-006860-a3b8hyyr	1198	26	momentum	momentum	NN
cord-006860-a3b8hyyr	1198	27	of	of	IN
cord-006860-a3b8hyyr	1198	28	the	the	DT
cord-006860-a3b8hyyr	1198	29	feather	feather	NN
cord-006860-a3b8hyyr	1198	30	.	.	.
cord-006860-a3b8hyyr	1199	1	Here	here	RB
cord-006860-a3b8hyyr	1199	2	the	the	DT
cord-006860-a3b8hyyr	1199	3	reduction	reduction	NN
cord-006860-a3b8hyyr	1199	4	of	of	IN
cord-006860-a3b8hyyr	1199	5	the	the	DT
cord-006860-a3b8hyyr	1199	6	rotation	rotation	NN
cord-006860-a3b8hyyr	1199	7	of	of	IN
cord-006860-a3b8hyyr	1199	8	the	the	DT
cord-006860-a3b8hyyr	1199	9	pin	pin	NN
cord-006860-a3b8hyyr	1199	10	,	,	,
cord-006860-a3b8hyyr	1199	11	which	which	WDT
cord-006860-a3b8hyyr	1199	12	is	be	VBZ
cord-006860-a3b8hyyr	1199	13	detected	detect	VBN
cord-006860-a3b8hyyr	1199	14	optically	optically	RB
cord-006860-a3b8hyyr	1199	15	,	,	,
cord-006860-a3b8hyyr	1199	16	is	be	VBZ
cord-006860-a3b8hyyr	1199	17	tranformed	tranforme	VBN
cord-006860-a3b8hyyr	1199	18	to	to	IN
cord-006860-a3b8hyyr	1199	19	the	the	DT
cord-006860-a3b8hyyr	1199	20	TEG	TEG	NNP
cord-006860-a3b8hyyr	1199	21	amplitude	amplitude	NN
cord-006860-a3b8hyyr	1199	22	.	.	.
cord-006860-a3b8hyyr	1200	1	As	as	IN
cord-006860-a3b8hyyr	1200	2	can	can	MD
cord-006860-a3b8hyyr	1200	3	be	be	VB
cord-006860-a3b8hyyr	1200	4	shown	show	VBN
cord-006860-a3b8hyyr	1200	5	by	by	IN
cord-006860-a3b8hyyr	1200	6	theoretical	theoretical	JJ
cord-006860-a3b8hyyr	1200	7	analysis	analysis	NN
cord-006860-a3b8hyyr	1200	8	and	and	CC
cord-006860-a3b8hyyr	1200	9	by	by	IN
cord-006860-a3b8hyyr	1200	10	control	control	NN
cord-006860-a3b8hyyr	1200	11	measurements	measurement	NNS
cord-006860-a3b8hyyr	1200	12	,	,	,
cord-006860-a3b8hyyr	1200	13	the	the	DT
cord-006860-a3b8hyyr	1200	14	roTEG	roteg	NN
cord-006860-a3b8hyyr	1200	15	provides	provide	VBZ
cord-006860-a3b8hyyr	1200	16	the	the	DT
cord-006860-a3b8hyyr	1200	17	same	same	JJ
cord-006860-a3b8hyyr	1200	18	measuring	measuring	NN
cord-006860-a3b8hyyr	1200	19	capabilities	capability	NNS
cord-006860-a3b8hyyr	1200	20	as	as	IN
cord-006860-a3b8hyyr	1200	21	conventional	conventional	JJ
cord-006860-a3b8hyyr	1200	22	TEG	TEG	NNP
cord-006860-a3b8hyyr	1200	23	systems	system	NNS
cord-006860-a3b8hyyr	1200	24	.	.	.
cord-006860-a3b8hyyr	1201	1	The	the	DT
cord-006860-a3b8hyyr	1201	2	main	main	JJ
cord-006860-a3b8hyyr	1201	3	advantage	advantage	NN
cord-006860-a3b8hyyr	1201	4	is	be	VBZ
cord-006860-a3b8hyyr	1201	5	the	the	DT
cord-006860-a3b8hyyr	1201	6	solid	solid	JJ
cord-006860-a3b8hyyr	1201	7	guiding	guiding	NN
cord-006860-a3b8hyyr	1201	8	of	of	IN
cord-006860-a3b8hyyr	1201	9	the	the	DT
cord-006860-a3b8hyyr	1201	10	measuring	measuring	NN
cord-006860-a3b8hyyr	1201	11	system	system	NN
cord-006860-a3b8hyyr	1201	12	,	,	,
cord-006860-a3b8hyyr	1201	13	which	which	WDT
cord-006860-a3b8hyyr	1201	14	makes	make	VBZ
cord-006860-a3b8hyyr	1201	15	the	the	DT
cord-006860-a3b8hyyr	1201	16	roTEG	roteg	RBR
cord-006860-a3b8hyyr	1201	17	easily	easily	RB
cord-006860-a3b8hyyr	1201	18	transportable	transportable	JJ
cord-006860-a3b8hyyr	1201	19	and	and	CC
cord-006860-a3b8hyyr	1201	20	less	less	RBR
cord-006860-a3b8hyyr	1201	21	susceptible	susceptible	JJ
cord-006860-a3b8hyyr	1201	22	to	to	IN
cord-006860-a3b8hyyr	1201	23	shock	shock	NN
cord-006860-a3b8hyyr	1201	24	or	or	CC
cord-006860-a3b8hyyr	1201	25	vibration	vibration	NN
cord-006860-a3b8hyyr	1201	26	during	during	IN
cord-006860-a3b8hyyr	1201	27	measurement	measurement	NN
cord-006860-a3b8hyyr	1201	28	.	.	.
cord-006860-a3b8hyyr	1202	1	Yhrombelastography	Yhrombelastography	NNP
cord-006860-a3b8hyyr	1202	2	(	(	-LRB-
cord-006860-a3b8hyyr	1202	3	TEG	TEG	NNP
cord-006860-a3b8hyyr	1202	4	)	)	-RRB-
cord-006860-a3b8hyyr	1202	5	is	be	VBZ
cord-006860-a3b8hyyr	1202	6	a	a	DT
cord-006860-a3b8hyyr	1202	7	standard	standard	JJ
cord-006860-a3b8hyyr	1202	8	monitoring	monitoring	NN
cord-006860-a3b8hyyr	1202	9	procedure	procedure	NN
cord-006860-a3b8hyyr	1202	10	for	for	IN
cord-006860-a3b8hyyr	1202	11	evaluation	evaluation	NN
cord-006860-a3b8hyyr	1202	12	of	of	IN
cord-006860-a3b8hyyr	1202	13	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1202	14	.	.	.
cord-006860-a3b8hyyr	1203	1	Usually	usually	RB
cord-006860-a3b8hyyr	1203	2	only	only	RB
cord-006860-a3b8hyyr	1203	3	nonactivated	nonactivate	VBD
cord-006860-a3b8hyyr	1203	4	native	native	JJ
cord-006860-a3b8hyyr	1203	5	blood	blood	NN
cord-006860-a3b8hyyr	1203	6	TEG	TEG	NNP
cord-006860-a3b8hyyr	1203	7	measurements	measurement	NNS
cord-006860-a3b8hyyr	1203	8	(	(	-LRB-
cord-006860-a3b8hyyr	1203	9	NaTEG	NaTEG	NNP
cord-006860-a3b8hyyr	1203	10	)	)	-RRB-
cord-006860-a3b8hyyr	1203	11	are	be	VBP
cord-006860-a3b8hyyr	1203	12	performed	perform	VBN
cord-006860-a3b8hyyr	1203	13	,	,	,
cord-006860-a3b8hyyr	1203	14	which	which	WDT
cord-006860-a3b8hyyr	1203	15	leads	lead	VBZ
cord-006860-a3b8hyyr	1203	16	to	to	IN
cord-006860-a3b8hyyr	1203	17	a	a	DT
cord-006860-a3b8hyyr	1203	18	)	)	-RRB-
cord-006860-a3b8hyyr	1203	19	a	a	DT
cord-006860-a3b8hyyr	1203	20	long	long	JJ
cord-006860-a3b8hyyr	1203	21	time	time	NN
cord-006860-a3b8hyyr	1203	22	interval	interval	NN
cord-006860-a3b8hyyr	1203	23	until	until	IN
cord-006860-a3b8hyyr	1203	24	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1203	25	and	and	CC
cord-006860-a3b8hyyr	1203	26	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1203	27	parameters	parameter	NNS
cord-006860-a3b8hyyr	1203	28	are	be	VBP
cord-006860-a3b8hyyr	1203	29	available	available	JJ
cord-006860-a3b8hyyr	1203	30	b	b	LS
cord-006860-a3b8hyyr	1203	31	)	)	-RRB-
cord-006860-a3b8hyyr	1203	32	very	very	RB
cord-006860-a3b8hyyr	1203	33	high	high	JJ
cord-006860-a3b8hyyr	1203	34	susceptibility	susceptibility	NN
cord-006860-a3b8hyyr	1203	35	of	of	IN
cord-006860-a3b8hyyr	1203	36	the	the	DT
cord-006860-a3b8hyyr	1203	37	measurement	measurement	NN
cord-006860-a3b8hyyr	1203	38	to	to	TO
cord-006860-a3b8hyyr	1203	39	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1203	40	like	like	IN
cord-006860-a3b8hyyr	1203	41	heparin	heparin	NN
cord-006860-a3b8hyyr	1203	42	,	,	,
cord-006860-a3b8hyyr	1203	43	which	which	WDT
cord-006860-a3b8hyyr	1203	44	disturbes	disturb	VBZ
cord-006860-a3b8hyyr	1203	45	the	the	DT
cord-006860-a3b8hyyr	1203	46	judgement	judgement	NN
cord-006860-a3b8hyyr	1203	47	of	of	IN
cord-006860-a3b8hyyr	1203	48	other	other	JJ
cord-006860-a3b8hyyr	1203	49	components	component	NNS
cord-006860-a3b8hyyr	1203	50	of	of	IN
cord-006860-a3b8hyyr	1203	51	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1203	52	,	,	,
cord-006860-a3b8hyyr	1203	53	c	c	NN
cord-006860-a3b8hyyr	1203	54	)	)	-RRB-
cord-006860-a3b8hyyr	1203	55	unspecific	unspecific	JJ
cord-006860-a3b8hyyr	1203	56	results	result	NNS
cord-006860-a3b8hyyr	1203	57	.	.	.
cord-006860-a3b8hyyr	1204	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	1204	2	aim	aim	NN
cord-006860-a3b8hyyr	1204	3	was	be	VBD
cord-006860-a3b8hyyr	1204	4	to	to	TO
cord-006860-a3b8hyyr	1204	5	develop	develop	VB
cord-006860-a3b8hyyr	1204	6	a	a	DT
cord-006860-a3b8hyyr	1204	7	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1204	8	monitoring	monitoring	NN
cord-006860-a3b8hyyr	1204	9	system	system	NN
cord-006860-a3b8hyyr	1204	10	based	base	VBN
cord-006860-a3b8hyyr	1204	11	on	on	IN
cord-006860-a3b8hyyr	1204	12	TEG	TEG	NNP
cord-006860-a3b8hyyr	1204	13	providing	provide	VBG
cord-006860-a3b8hyyr	1204	14	fast	fast	JJ
cord-006860-a3b8hyyr	1204	15	and	and	CC
cord-006860-a3b8hyyr	1204	16	specific	specific	JJ
cord-006860-a3b8hyyr	1204	17	information	information	NN
cord-006860-a3b8hyyr	1204	18	on	on	IN
cord-006860-a3b8hyyr	1204	19	the	the	DT
cord-006860-a3b8hyyr	1204	20	different	different	JJ
cord-006860-a3b8hyyr	1204	21	components	component	NNS
cord-006860-a3b8hyyr	1204	22	of	of	IN
cord-006860-a3b8hyyr	1204	23	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1204	24	.	.	.
cord-006860-a3b8hyyr	1205	1	Methods	method	NNS
cord-006860-a3b8hyyr	1205	2	:	:	:
cord-006860-a3b8hyyr	1205	3	The	the	DT
cord-006860-a3b8hyyr	1205	4	following	follow	VBG
cord-006860-a3b8hyyr	1205	5	measurements	measurement	NNS
cord-006860-a3b8hyyr	1205	6	are	be	VBP
cord-006860-a3b8hyyr	1205	7	performed	perform	VBN
cord-006860-a3b8hyyr	1205	8	in	in	IN
cord-006860-a3b8hyyr	1205	9	paralel	paralel	NNS
cord-006860-a3b8hyyr	1205	10	using	use	VBG
cord-006860-a3b8hyyr	1205	11	disposable	disposable	JJ
cord-006860-a3b8hyyr	1205	12	pins	pin	NNS
cord-006860-a3b8hyyr	1205	13	/	/	SYM
cord-006860-a3b8hyyr	1205	14	cups	cup	NNS
cord-006860-a3b8hyyr	1205	15	(	(	-LRB-
cord-006860-a3b8hyyr	1205	16	Haemoscope	Haemoscope	NNP
cord-006860-a3b8hyyr	1205	17	)	)	-RRB-
cord-006860-a3b8hyyr	1205	18	:	:	:
cord-006860-a3b8hyyr	1205	19	a	a	LS
cord-006860-a3b8hyyr	1205	20	)	)	-RRB-
cord-006860-a3b8hyyr	1205	21	Extrinsic	extrinsic	NN
cord-006860-a3b8hyyr	1205	22	activated	activate	VBN
cord-006860-a3b8hyyr	1205	23	TEG	TEG	NNP
cord-006860-a3b8hyyr	1205	24	(	(	-LRB-
cord-006860-a3b8hyyr	1205	25	ExTEG	ExTEG	NNP
cord-006860-a3b8hyyr	1205	26	)	)	-RRB-
cord-006860-a3b8hyyr	1205	27	:	:	:
cord-006860-a3b8hyyr	1205	28	3551al	3551al	JJ
cord-006860-a3b8hyyr	1205	29	whole	whole	JJ
cord-006860-a3b8hyyr	1205	30	blood	blood	NN
cord-006860-a3b8hyyr	1205	31	(	(	-LRB-
cord-006860-a3b8hyyr	1205	32	WB	WB	NNP
cord-006860-a3b8hyyr	1205	33	)	)	-RRB-
cord-006860-a3b8hyyr	1206	1	+	+	CC
cord-006860-a3b8hyyr	1206	2	5~tl	5~tl	CD
cord-006860-a3b8hyyr	1206	3	Innovin	Innovin	NNP
cord-006860-a3b8hyyr	1206	4	(	(	-LRB-
cord-006860-a3b8hyyr	1206	5	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	1206	6	thromboplastin	thromboplastin	NN
cord-006860-a3b8hyyr	1206	7	reagent	reagent	NN
cord-006860-a3b8hyyr	1206	8	,	,	,
cord-006860-a3b8hyyr	1206	9	Dade	Dade	NNP
cord-006860-a3b8hyyr	1206	10	)	)	-RRB-
cord-006860-a3b8hyyr	1206	11	.	.	.
cord-006860-a3b8hyyr	1207	1	b	b	LS
cord-006860-a3b8hyyr	1207	2	)	)	-RRB-
cord-006860-a3b8hyyr	1208	1	Intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	1209	1	activated	activate	VBN
cord-006860-a3b8hyyr	1209	2	TEG	TEG	NNP
cord-006860-a3b8hyyr	1209	3	(	(	-LRB-
cord-006860-a3b8hyyr	1209	4	InTEG	InTEG	NNP
cord-006860-a3b8hyyr	1209	5	)	)	-RRB-
cord-006860-a3b8hyyr	1209	6	:	:	:
cord-006860-a3b8hyyr	1210	1	3551al	3551al	NNP
cord-006860-a3b8hyyr	1210	2	WB	WB	NNP
cord-006860-a3b8hyyr	1210	3	+	+	CC
cord-006860-a3b8hyyr	1211	1	5~tl	5~tl	CD
cord-006860-a3b8hyyr	1211	2	Kaolin	Kaolin	NNP
cord-006860-a3b8hyyr	1211	3	(	(	-LRB-
cord-006860-a3b8hyyr	1211	4	suspension	suspension	NN
cord-006860-a3b8hyyr	1211	5	5g	5g	CD
cord-006860-a3b8hyyr	1211	6	/	/	SYM
cord-006860-a3b8hyyr	1211	7	l	l	NN
cord-006860-a3b8hyyr	1211	8	,	,	,
cord-006860-a3b8hyyr	1211	9	Behring	Behring	NNP
cord-006860-a3b8hyyr	1211	10	)	)	-RRB-
cord-006860-a3b8hyyr	1211	11	.	.	.
cord-006860-a3b8hyyr	1212	1	c	c	LS
cord-006860-a3b8hyyr	1212	2	)	)	-RRB-
cord-006860-a3b8hyyr	1213	1	Aprotinin	Aprotinin	NNP
cord-006860-a3b8hyyr	1213	2	TEG	TEG	NNP
cord-006860-a3b8hyyr	1213	3	(	(	-LRB-
cord-006860-a3b8hyyr	1213	4	ApTEG	ApTEG	NNP
cord-006860-a3b8hyyr	1213	5	)	)	-RRB-
cord-006860-a3b8hyyr	1213	6	:	:	:
cord-006860-a3b8hyyr	1213	7	ExTEG	exteg	NN
cord-006860-a3b8hyyr	1213	8	+	+	CC
cord-006860-a3b8hyyr	1214	1	20	20	CD
cord-006860-a3b8hyyr	1214	2	KIE	KIE	NNP
cord-006860-a3b8hyyr	1214	3	Aprotinin	Aprotinin	NNP
cord-006860-a3b8hyyr	1214	4	(	(	-LRB-
cord-006860-a3b8hyyr	1214	5	Trasylol	Trasylol	NNP
cord-006860-a3b8hyyr	1214	6	,	,	,
cord-006860-a3b8hyyr	1214	7	Bayer	Bayer	NNP
cord-006860-a3b8hyyr	1214	8	)	)	-RRB-
cord-006860-a3b8hyyr	1214	9	.	.	.
cord-006860-a3b8hyyr	1215	1	d	d	LS
cord-006860-a3b8hyyr	1215	2	)	)	-RRB-
cord-006860-a3b8hyyr	1216	1	Heparinase	Heparinase	NNP
cord-006860-a3b8hyyr	1216	2	TEG	TEG	NNP
cord-006860-a3b8hyyr	1216	3	(	(	-LRB-
cord-006860-a3b8hyyr	1216	4	HepTEG	HepTEG	NNP
cord-006860-a3b8hyyr	1216	5	)	)	-RRB-
cord-006860-a3b8hyyr	1217	1	as	as	IN
cord-006860-a3b8hyyr	1217	2	decribed	decribe	VBN
cord-006860-a3b8hyyr	1217	3	in	in	IN
cord-006860-a3b8hyyr	1217	4	(	(	-LRB-
cord-006860-a3b8hyyr	1217	5	1	1	CD
cord-006860-a3b8hyyr	1217	6	)	)	-RRB-
cord-006860-a3b8hyyr	1217	7	.	.	.
cord-006860-a3b8hyyr	1218	1	Results	result	NNS
cord-006860-a3b8hyyr	1218	2	:	:	:
cord-006860-a3b8hyyr	1219	1	ExTEG	ExTEG	NNP
cord-006860-a3b8hyyr	1219	2	and	and	CC
cord-006860-a3b8hyyr	1219	3	InTEG	InTEG	NNP
cord-006860-a3b8hyyr	1219	4	provide	provide	VBP
cord-006860-a3b8hyyr	1219	5	information	information	NN
cord-006860-a3b8hyyr	1219	6	on	on	IN
cord-006860-a3b8hyyr	1219	7	the	the	DT
cord-006860-a3b8hyyr	1219	8	extrinsic	extrinsic	JJ
cord-006860-a3b8hyyr	1219	9	/	/	SYM
cord-006860-a3b8hyyr	1219	10	intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	1219	11	system	system	NN
cord-006860-a3b8hyyr	1219	12	within	within	IN
cord-006860-a3b8hyyr	1219	13	5	5	CD
cord-006860-a3b8hyyr	1219	14	-	-	SYM
cord-006860-a3b8hyyr	1219	15	10	10	CD
cord-006860-a3b8hyyr	1219	16	min	min	NN
cord-006860-a3b8hyyr	1219	17	and	and	CC
cord-006860-a3b8hyyr	1219	18	information	information	NN
cord-006860-a3b8hyyr	1219	19	on	on	IN
cord-006860-a3b8hyyr	1219	20	the	the	DT
cord-006860-a3b8hyyr	1219	21	platelet	platelet	NN
cord-006860-a3b8hyyr	1219	22	/	/	SYM
cord-006860-a3b8hyyr	1219	23	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1219	24	status	status	NN
cord-006860-a3b8hyyr	1219	25	within	within	IN
cord-006860-a3b8hyyr	1219	26	10	10	CD
cord-006860-a3b8hyyr	1219	27	-	-	SYM
cord-006860-a3b8hyyr	1219	28	20	20	CD
cord-006860-a3b8hyyr	1219	29	min	min	NN
cord-006860-a3b8hyyr	1219	30	.	.	.
cord-006860-a3b8hyyr	1220	1	Because	because	IN
cord-006860-a3b8hyyr	1220	2	of	of	IN
cord-006860-a3b8hyyr	1220	3	the	the	DT
cord-006860-a3b8hyyr	1220	4	addition	addition	NN
cord-006860-a3b8hyyr	1220	5	of	of	IN
cord-006860-a3b8hyyr	1220	6	potent	potent	JJ
cord-006860-a3b8hyyr	1220	7	activators	activator	NNS
cord-006860-a3b8hyyr	1220	8	InTEG	integ	XX
cord-006860-a3b8hyyr	1221	1	and	and	CC
cord-006860-a3b8hyyr	1221	2	ExTEG	ExTEG	NNP
cord-006860-a3b8hyyr	1221	3	can	can	MD
cord-006860-a3b8hyyr	1221	4	be	be	VB
cord-006860-a3b8hyyr	1221	5	performed	perform	VBN
cord-006860-a3b8hyyr	1221	6	when	when	WRB
cord-006860-a3b8hyyr	1221	7	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1221	8	like	like	IN
cord-006860-a3b8hyyr	1221	9	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	1221	10	are	be	VBP
cord-006860-a3b8hyyr	1221	11	present	present	JJ
cord-006860-a3b8hyyr	1221	12	in	in	IN
cord-006860-a3b8hyyr	1221	13	the	the	DT
cord-006860-a3b8hyyr	1221	14	circulation	circulation	NN
cord-006860-a3b8hyyr	1221	15	.	.	.
cord-006860-a3b8hyyr	1222	1	Fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1222	2	effects	effect	NNS
cord-006860-a3b8hyyr	1222	3	can	can	MD
cord-006860-a3b8hyyr	1222	4	be	be	VB
cord-006860-a3b8hyyr	1222	5	seen	see	VBN
cord-006860-a3b8hyyr	1222	6	on	on	IN
cord-006860-a3b8hyyr	1222	7	ExTEG	ExTEG	NNP
cord-006860-a3b8hyyr	1222	8	and	and	CC
cord-006860-a3b8hyyr	1222	9	InTEG	InTEG	NNP
cord-006860-a3b8hyyr	1223	1	and	and	CC
cord-006860-a3b8hyyr	1223	2	by	by	IN
cord-006860-a3b8hyyr	1223	3	comparison	comparison	NN
cord-006860-a3b8hyyr	1223	4	of	of	IN
cord-006860-a3b8hyyr	1223	5	ExTEG	ExTEG	NNP
cord-006860-a3b8hyyr	1224	1	and	and	CC
cord-006860-a3b8hyyr	1225	1	ApTEG	ApTEG	NNP
cord-006860-a3b8hyyr	1225	2	(	(	-LRB-
cord-006860-a3b8hyyr	1225	3	ApTEG	ApTEG	NNP
cord-006860-a3b8hyyr	1225	4	:	:	:
cord-006860-a3b8hyyr	1225	5	invitro	invitro	NNP
cord-006860-a3b8hyyr	1225	6	-	-	HYPH
cord-006860-a3b8hyyr	1225	7	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1225	8	inhibition	inhibition	NN
cord-006860-a3b8hyyr	1225	9	by	by	IN
cord-006860-a3b8hyyr	1225	10	Aprotinin	Aprotinin	NNP
cord-006860-a3b8hyyr	1225	11	)	)	-RRB-
cord-006860-a3b8hyyr	1225	12	.	.	.
cord-006860-a3b8hyyr	1226	1	If	if	IN
cord-006860-a3b8hyyr	1226	2	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1226	3	is	be	VBZ
cord-006860-a3b8hyyr	1226	4	detected	detect	VBN
cord-006860-a3b8hyyr	1226	5	by	by	IN
cord-006860-a3b8hyyr	1226	6	ExTEG	ExTEG	NNP
cord-006860-a3b8hyyr	1226	7	or	or	CC
cord-006860-a3b8hyyr	1226	8	InTEG	InTEG	NNP
cord-006860-a3b8hyyr	1226	9	and	and	CC
cord-006860-a3b8hyyr	1226	10	aprotinin	aprotinin	NN
cord-006860-a3b8hyyr	1226	11	-	-	HYPH
cord-006860-a3b8hyyr	1226	12	susceptibility	susceptibility	NN
cord-006860-a3b8hyyr	1226	13	is	be	VBZ
cord-006860-a3b8hyyr	1226	14	verified	verify	VBN
cord-006860-a3b8hyyr	1226	15	by	by	IN
cord-006860-a3b8hyyr	1227	1	ApTEG	ApTEG	NNP
cord-006860-a3b8hyyr	1227	2	,	,	,
cord-006860-a3b8hyyr	1227	3	aprotinin	aprotinin	NN
cord-006860-a3b8hyyr	1227	4	therapy	therapy	NN
cord-006860-a3b8hyyr	1227	5	will	will	MD
cord-006860-a3b8hyyr	1227	6	be	be	VB
cord-006860-a3b8hyyr	1227	7	initiated	initiate	VBN
cord-006860-a3b8hyyr	1227	8	.	.	.
cord-006860-a3b8hyyr	1228	1	Heparin	heparin	JJ
cord-006860-a3b8hyyr	1228	2	effects	effect	NNS
cord-006860-a3b8hyyr	1228	3	are	be	VBP
cord-006860-a3b8hyyr	1228	4	revealed	reveal	VBN
cord-006860-a3b8hyyr	1228	5	by	by	IN
cord-006860-a3b8hyyr	1228	6	HepTEG	HepTEG	NNS
cord-006860-a3b8hyyr	1228	7	.	.	.
cord-006860-a3b8hyyr	1228	8	Discussion	discussion	NN
cord-006860-a3b8hyyr	1228	9	:	:	:
cord-006860-a3b8hyyr	1229	1	By	by	IN
cord-006860-a3b8hyyr	1229	2	the	the	DT
cord-006860-a3b8hyyr	1229	3	comparison	comparison	NN
cord-006860-a3b8hyyr	1229	4	of	of	IN
cord-006860-a3b8hyyr	1229	5	parallel	parallel	JJ
cord-006860-a3b8hyyr	1229	6	TEG	TEG	NNP
cord-006860-a3b8hyyr	1229	7	measurements	measurement	NNS
cord-006860-a3b8hyyr	1229	8	which	which	WDT
cord-006860-a3b8hyyr	1229	9	have	have	VBP
cord-006860-a3b8hyyr	1229	10	been	be	VBN
cord-006860-a3b8hyyr	1229	11	differently	differently	RB
cord-006860-a3b8hyyr	1229	12	activated	activate	VBN
cord-006860-a3b8hyyr	1229	13	,	,	,
cord-006860-a3b8hyyr	1229	14	specific	specific	JJ
cord-006860-a3b8hyyr	1229	15	and	and	CC
cord-006860-a3b8hyyr	1229	16	fast	fast	JJ
cord-006860-a3b8hyyr	1229	17	information	information	NN
cord-006860-a3b8hyyr	1229	18	on	on	IN
cord-006860-a3b8hyyr	1229	19	the	the	DT
cord-006860-a3b8hyyr	1229	20	different	different	JJ
cord-006860-a3b8hyyr	1229	21	aspects	aspect	NNS
cord-006860-a3b8hyyr	1229	22	of	of	IN
cord-006860-a3b8hyyr	1229	23	the	the	DT
cord-006860-a3b8hyyr	1229	24	clinical	clinical	JJ
cord-006860-a3b8hyyr	1229	25	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1229	26	status	status	NN
cord-006860-a3b8hyyr	1229	27	is	be	VBZ
cord-006860-a3b8hyyr	1229	28	provided	provide	VBN
cord-006860-a3b8hyyr	1229	29	.	.	.
cord-006860-a3b8hyyr	1230	1	The	the	DT
cord-006860-a3b8hyyr	1230	2	presented	present	VBN
cord-006860-a3b8hyyr	1230	3	tests	test	NNS
cord-006860-a3b8hyyr	1230	4	can	can	MD
cord-006860-a3b8hyyr	1230	5	be	be	VB
cord-006860-a3b8hyyr	1230	6	easily	easily	RB
cord-006860-a3b8hyyr	1230	7	performed	perform	VBN
cord-006860-a3b8hyyr	1230	8	bedside	bedside	NN
cord-006860-a3b8hyyr	1230	9	and	and	CC
cord-006860-a3b8hyyr	1230	10	only	only	RB
cord-006860-a3b8hyyr	1230	11	a	a	DT
cord-006860-a3b8hyyr	1230	12	small	small	JJ
cord-006860-a3b8hyyr	1230	13	specimen	specimen	NN
cord-006860-a3b8hyyr	1230	14	of	of	IN
cord-006860-a3b8hyyr	1230	15	whole	whole	JJ
cord-006860-a3b8hyyr	1230	16	blood	blood	NN
cord-006860-a3b8hyyr	1230	17	is	be	VBZ
cord-006860-a3b8hyyr	1230	18	needed	need	VBN
cord-006860-a3b8hyyr	1230	19	(	(	-LRB-
cord-006860-a3b8hyyr	1230	20	0,4	0,4	CD
cord-006860-a3b8hyyr	1230	21	-	-	HYPH
cord-006860-a3b8hyyr	1230	22	1,8	1,8	CD
cord-006860-a3b8hyyr	1230	23	ml	ml	NN
cord-006860-a3b8hyyr	1230	24	)	)	-RRB-
cord-006860-a3b8hyyr	1230	25	.	.	.
cord-006860-a3b8hyyr	1231	1	Introduction	introduction	NN
cord-006860-a3b8hyyr	1231	2	:	:	:
cord-006860-a3b8hyyr	1232	1	A	a	DT
cord-006860-a3b8hyyr	1232	2	severely	severely	RB
cord-006860-a3b8hyyr	1232	3	prolonged	prolong	VBN
cord-006860-a3b8hyyr	1232	4	aPTT	aptt	CD
cord-006860-a3b8hyyr	1233	1	(	(	-LRB-
cord-006860-a3b8hyyr	1233	2	333s	333	NNS
cord-006860-a3b8hyyr	1233	3	;	;	:
cord-006860-a3b8hyyr	1233	4	normal	normal	JJ
cord-006860-a3b8hyyr	1233	5	:	:	:
cord-006860-a3b8hyyr	1233	6	40~Os	40~os	CD
cord-006860-a3b8hyyr	1233	7	)	)	-RRB-
cord-006860-a3b8hyyr	1233	8	was	be	VBD
cord-006860-a3b8hyyr	1233	9	observed	observe	VBN
cord-006860-a3b8hyyr	1233	10	during	during	IN
cord-006860-a3b8hyyr	1233	11	preoperative	preoperative	JJ
cord-006860-a3b8hyyr	1233	12	screening	screening	NN
cord-006860-a3b8hyyr	1233	13	for	for	IN
cord-006860-a3b8hyyr	1233	14	a	a	DT
cord-006860-a3b8hyyr	1233	15	planned	planned	JJ
cord-006860-a3b8hyyr	1233	16	splenectomy	splenectomy	NN
cord-006860-a3b8hyyr	1233	17	in	in	IN
cord-006860-a3b8hyyr	1233	18	a	a	DT
cord-006860-a3b8hyyr	1233	19	71-year	71-year	JJ
cord-006860-a3b8hyyr	1233	20	-	-	HYPH
cord-006860-a3b8hyyr	1233	21	old	old	JJ
cord-006860-a3b8hyyr	1233	22	man	man	NN
cord-006860-a3b8hyyr	1233	23	with	with	IN
cord-006860-a3b8hyyr	1233	24	an	an	DT
cord-006860-a3b8hyyr	1233	25	8	8	CD
cord-006860-a3b8hyyr	1233	26	year	year	NN
cord-006860-a3b8hyyr	1233	27	history	history	NN
cord-006860-a3b8hyyr	1233	28	of	of	IN
cord-006860-a3b8hyyr	1233	29	osteomyelofibrosis	osteomyelofibrosis	NNP
cord-006860-a3b8hyyr	1233	30	.	.	.
cord-006860-a3b8hyyr	1234	1	Fellewing	Fellewing	NNP
cord-006860-a3b8hyyr	1234	2	neer	neer	NNP
cord-006860-a3b8hyyr	1234	3	-	-	HYPH
cord-006860-a3b8hyyr	1234	4	normal	normal	JJ
cord-006860-a3b8hyyr	1234	5	~	~	NFP
cord-006860-a3b8hyyr	1234	6	atien	atien	NNP
cord-006860-a3b8hyyr	1234	7	(	(	-LRB-
cord-006860-a3b8hyyr	1234	8	71s	71s	NNP
cord-006860-a3b8hyyr	1234	9	)	)	-RRB-
cord-006860-a3b8hyyr	1234	10	of	of	IN
cord-006860-a3b8hyyr	1234	11	the	the	DT
cord-006860-a3b8hyyr	1234	12	aP'CI	aP'CI	NNP
cord-006860-a3b8hyyr	1234	13	"	"	''
cord-006860-a3b8hyyr	1234	14	after	after	IN
cord-006860-a3b8hyyr	1234	15	10	10	CD
cord-006860-a3b8hyyr	1234	16	rain	rain	NN
cord-006860-a3b8hyyr	1234	17	preincubation	preincubation	NN
cord-006860-a3b8hyyr	1234	18	in	in	IN
cord-006860-a3b8hyyr	1234	19	a	a	DT
cord-006860-a3b8hyyr	1234	20	kaolin	kaolin	NN
cord-006860-a3b8hyyr	1234	21	based	base	VBN
cord-006860-a3b8hyyr	1234	22	aPTT	aptt	JJ
cord-006860-a3b8hyyr	1234	23	assay	assay	NN
cord-006860-a3b8hyyr	1234	24	,	,	,
cord-006860-a3b8hyyr	1234	25	PK	PK	NNP
cord-006860-a3b8hyyr	1234	26	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1234	27	was	be	VBD
cord-006860-a3b8hyyr	1234	28	suspected	suspect	VBN
cord-006860-a3b8hyyr	1234	29	and	and	CC
cord-006860-a3b8hyyr	1234	30	studies	study	NNS
cord-006860-a3b8hyyr	1234	31	were	be	VBD
cord-006860-a3b8hyyr	1234	32	performed	perform	VBN
cord-006860-a3b8hyyr	1234	33	to	to	TO
cord-006860-a3b8hyyr	1234	34	further	further	RB
cord-006860-a3b8hyyr	1234	35	investigate	investigate	VB
cord-006860-a3b8hyyr	1234	36	the	the	DT
cord-006860-a3b8hyyr	1234	37	nature	nature	NN
cord-006860-a3b8hyyr	1234	38	of	of	IN
cord-006860-a3b8hyyr	1234	39	the	the	DT
cord-006860-a3b8hyyr	1234	40	PK	PK	NNP
cord-006860-a3b8hyyr	1234	41	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1234	42	as	as	RB
cord-006860-a3b8hyyr	1234	43	well	well	RB
cord-006860-a3b8hyyr	1234	44	as	as	IN
cord-006860-a3b8hyyr	1234	45	the	the	DT
cord-006860-a3b8hyyr	1234	46	mechanism	mechanism	NN
cord-006860-a3b8hyyr	1234	47	underlying	underlie	VBG
cord-006860-a3b8hyyr	1234	48	the	the	DT
cord-006860-a3b8hyyr	1234	49	normalization	normalization	NN
cord-006860-a3b8hyyr	1234	50	of	of	IN
cord-006860-a3b8hyyr	1234	51	the	the	DT
cord-006860-a3b8hyyr	1234	52	prolonged	prolong	VBN
cord-006860-a3b8hyyr	1234	53	aPTT	aPTT	NNS
cord-006860-a3b8hyyr	1234	54	by	by	IN
cord-006860-a3b8hyyr	1234	55	increasing	increase	VBG
cord-006860-a3b8hyyr	1234	56	the	the	DT
cord-006860-a3b8hyyr	1234	57	preincubation	preincubation	NN
cord-006860-a3b8hyyr	1234	58	time	time	NN
cord-006860-a3b8hyyr	1234	59	.	.	.
cord-006860-a3b8hyyr	1235	1	Methods	method	NNS
cord-006860-a3b8hyyr	1235	2	:	:	:
cord-006860-a3b8hyyr	1236	1	The	the	DT
cord-006860-a3b8hyyr	1236	2	aPl	aPl	NNP
cord-006860-a3b8hyyr	1236	3	-	-	HYPH
cord-006860-a3b8hyyr	1236	4	r	r	NN
cord-006860-a3b8hyyr	1236	5	assay	assay	NN
cord-006860-a3b8hyyr	1236	6	was	be	VBD
cord-006860-a3b8hyyr	1236	7	peal'armed	peal'arme	VBN
cord-006860-a3b8hyyr	1236	8	using	use	VBG
cord-006860-a3b8hyyr	1236	9	kaolin	kaolin	NN
cord-006860-a3b8hyyr	1236	10	/	/	SYM
cord-006860-a3b8hyyr	1236	11	inesithin	inesithin	NNP
cord-006860-a3b8hyyr	1236	12	.	.	.
cord-006860-a3b8hyyr	1237	1	High	high	JJ
cord-006860-a3b8hyyr	1237	2	molecular	molecular	JJ
cord-006860-a3b8hyyr	1237	3	weight	weight	NN
cord-006860-a3b8hyyr	1237	4	kininogen	kininogen	NNP
cord-006860-a3b8hyyr	1237	5	clotting	clot	VBG
cord-006860-a3b8hyyr	1237	6	activitiy	activitiy	NNP
cord-006860-a3b8hyyr	1237	7	(	(	-LRB-
cord-006860-a3b8hyyr	1237	8	HK	HK	NNP
cord-006860-a3b8hyyr	1237	9	:	:	:
cord-006860-a3b8hyyr	1237	10	C	C	NNP
cord-006860-a3b8hyyr	1237	11	)	)	-RRB-
cord-006860-a3b8hyyr	1237	12	,	,	.
cord-006860-a3b8hyyr	1238	1	FXII	FXII	NNP
cord-006860-a3b8hyyr	1238	2	:	:	:
cord-006860-a3b8hyyr	1239	1	C	C	NNP
cord-006860-a3b8hyyr	1239	2	end	end	NN
cord-006860-a3b8hyyr	1239	3	PK	PK	NNP
cord-006860-a3b8hyyr	1239	4	:	:	:
cord-006860-a3b8hyyr	1239	5	C	C	NNP
cord-006860-a3b8hyyr	1239	6	were	be	VBD
cord-006860-a3b8hyyr	1239	7	measured	measure	VBN
cord-006860-a3b8hyyr	1239	8	by	by	IN
cord-006860-a3b8hyyr	1239	9	an	an	DT
cord-006860-a3b8hyyr	1239	10	aPTT	aptt	NN
cord-006860-a3b8hyyr	1239	11	based	base	VBN
cord-006860-a3b8hyyr	1239	12	assay	assay	NN
cord-006860-a3b8hyyr	1239	13	using	use	VBG
cord-006860-a3b8hyyr	1239	14	Neothromtin	Neothromtin	NNP
cord-006860-a3b8hyyr	1239	15	®	®	.
cord-006860-a3b8hyyr	1239	16	(	(	-LRB-
cord-006860-a3b8hyyr	1239	17	Behnng	Behnng	NNP
cord-006860-a3b8hyyr	1239	18	)	)	-RRB-
cord-006860-a3b8hyyr	1239	19	and	and	CC
cord-006860-a3b8hyyr	1239	20	1	1	CD
cord-006860-a3b8hyyr	1239	21	rain	rain	NN
cord-006860-a3b8hyyr	1239	22	(	(	-LRB-
cord-006860-a3b8hyyr	1239	23	PK	pk	NN
cord-006860-a3b8hyyr	1239	24	:	:	:
cord-006860-a3b8hyyr	1239	25	C	C	NNP
cord-006860-a3b8hyyr	1239	26	)	)	-RRB-
cord-006860-a3b8hyyr	1239	27	or	or	CC
cord-006860-a3b8hyyr	1239	28	4	4	CD
cord-006860-a3b8hyyr	1239	29	min	min	NN
cord-006860-a3b8hyyr	1240	1	(	(	-LRB-
cord-006860-a3b8hyyr	1240	2	HK	HK	NNP
cord-006860-a3b8hyyr	1240	3	:	:	:
cord-006860-a3b8hyyr	1240	4	C	C	NNP
cord-006860-a3b8hyyr	1240	5	,	,	,
cord-006860-a3b8hyyr	1240	6	FXlI	FXlI	NNP
cord-006860-a3b8hyyr	1240	7	:	:	:
cord-006860-a3b8hyyr	1240	8	C	C	NNP
cord-006860-a3b8hyyr	1240	9	)	)	-RRB-
cord-006860-a3b8hyyr	1240	10	preincubation	preincubation	NN
cord-006860-a3b8hyyr	1240	11	.	.	.
cord-006860-a3b8hyyr	1241	1	PK	PK	NNP
cord-006860-a3b8hyyr	1241	2	amidolytic	amidolytic	JJ
cord-006860-a3b8hyyr	1241	3	activity	activity	NN
cord-006860-a3b8hyyr	1241	4	(	(	-LRB-
cord-006860-a3b8hyyr	1241	5	PK	PK	NNP
cord-006860-a3b8hyyr	1241	6	:	:	:
cord-006860-a3b8hyyr	1241	7	Am	Am	NNP
cord-006860-a3b8hyyr	1241	8	)	)	-RRB-
cord-006860-a3b8hyyr	1241	9	was	be	VBD
cord-006860-a3b8hyyr	1241	10	assayed	assay	VBN
cord-006860-a3b8hyyr	1241	11	using	use	VBG
cord-006860-a3b8hyyr	1241	12	Cosset	Cosset	NNP
cord-006860-a3b8hyyr	1241	13	PK	PK	NNP
cord-006860-a3b8hyyr	1241	14	~	~	NFP
cord-006860-a3b8hyyr	1241	15	(	(	-LRB-
cord-006860-a3b8hyyr	1241	16	Chromogenix	Chromogenix	NNP
cord-006860-a3b8hyyr	1241	17	)	)	-RRB-
cord-006860-a3b8hyyr	1241	18	and	and	CC
cord-006860-a3b8hyyr	1241	19	PK	PK	NNP
cord-006860-a3b8hyyr	1241	20	antigen	antigen	NNP
cord-006860-a3b8hyyr	1241	21	(	(	-LRB-
cord-006860-a3b8hyyr	1241	22	PK	PK	NNP
cord-006860-a3b8hyyr	1241	23	:	:	:
cord-006860-a3b8hyyr	1241	24	Ag	Ag	NNP
cord-006860-a3b8hyyr	1241	25	)	)	-RRB-
cord-006860-a3b8hyyr	1241	26	by	by	IN
cord-006860-a3b8hyyr	1241	27	quantitative	quantitative	JJ
cord-006860-a3b8hyyr	1241	28	immunoblotting	immunoblotting	NN
cord-006860-a3b8hyyr	1241	29	.	.	.
cord-006860-a3b8hyyr	1242	1	FXll	FXll	NNP
cord-006860-a3b8hyyr	1242	2	and	and	CC
cord-006860-a3b8hyyr	1242	3	HK	HK	NNP
cord-006860-a3b8hyyr	1242	4	proteolysis	proteolysis	NN
cord-006860-a3b8hyyr	1242	5	dunng	dunng	JJ
cord-006860-a3b8hyyr	1242	6	activation	activation	NN
cord-006860-a3b8hyyr	1242	7	of	of	IN
cord-006860-a3b8hyyr	1242	8	plasma	plasma	NN
cord-006860-a3b8hyyr	1242	9	by	by	IN
cord-006860-a3b8hyyr	1242	10	kaolin	kaolin	NN
cord-006860-a3b8hyyr	1242	11	(	(	-LRB-
cord-006860-a3b8hyyr	1242	12	10mg	10mg	NNP
cord-006860-a3b8hyyr	1242	13	/	/	SYM
cord-006860-a3b8hyyr	1242	14	ml	ml	XX
cord-006860-a3b8hyyr	1242	15	at	at	IN
cord-006860-a3b8hyyr	1242	16	37	37	CD
cord-006860-a3b8hyyr	1242	17	=	=	SYM
cord-006860-a3b8hyyr	1242	18	C	C	NNP
cord-006860-a3b8hyyr	1242	19	)	)	-RRB-
cord-006860-a3b8hyyr	1242	20	or	or	CC
cord-006860-a3b8hyyr	1242	21	DS	DS	NNP
cord-006860-a3b8hyyr	1242	22	(	(	-LRB-
cord-006860-a3b8hyyr	1242	23	12.5~tglml	12.5~tglml	CD
cord-006860-a3b8hyyr	1242	24	at	at	IN
cord-006860-a3b8hyyr	1242	25	4	4	CD
cord-006860-a3b8hyyr	1242	26	=	=	SYM
cord-006860-a3b8hyyr	1242	27	C	c	NN
cord-006860-a3b8hyyr	1242	28	)	)	-RRB-
cord-006860-a3b8hyyr	1242	29	was	be	VBD
cord-006860-a3b8hyyr	1242	30	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	1242	31	by	by	IN
cord-006860-a3b8hyyr	1242	32	immunotilotting	immunotilotting	JJ
cord-006860-a3b8hyyr	1242	33	assays	assay	NNS
cord-006860-a3b8hyyr	1242	34	of	of	IN
cord-006860-a3b8hyyr	1242	35	FXII	FXII	NNP
cord-006860-a3b8hyyr	1242	36	and	and	CC
cord-006860-a3b8hyyr	1242	37	HK	HK	NNP
cord-006860-a3b8hyyr	1242	38	following	follow	VBG
cord-006860-a3b8hyyr	1242	39	SDS	SDS	NNP
cord-006860-a3b8hyyr	1242	40	-	-	HYPH
cord-006860-a3b8hyyr	1242	41	PAGE	PAGE	NNP
cord-006860-a3b8hyyr	1242	42	.	.	.
cord-006860-a3b8hyyr	1243	1	Assay	assay	NN
cord-006860-a3b8hyyr	1243	2	PK	PK	NNP
cord-006860-a3b8hyyr	1243	3	:	:	:
cord-006860-a3b8hyyr	1243	4	C	C	NNP
cord-006860-a3b8hyyr	1243	5	PK	PK	NNP
cord-006860-a3b8hyyr	1243	6	:	:	:
cord-006860-a3b8hyyr	1244	1	Am	be	VBP
cord-006860-a3b8hyyr	1244	2	PK	PK	NNP
cord-006860-a3b8hyyr	1244	3	:	:	:
cord-006860-a3b8hyyr	1245	1	A~	A~	NNS
cord-006860-a3b8hyyr	1246	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	1246	2	FXfi	FXfi	NNP
cord-006860-a3b8hyyr	1246	3	:	:	:
cord-006860-a3b8hyyr	1247	1	The	the	DT
cord-006860-a3b8hyyr	1247	2	propositus	propositus	NN
cord-006860-a3b8hyyr	1247	3	had	have	VBD
cord-006860-a3b8hyyr	1247	4	PK	PK	NNP
cord-006860-a3b8hyyr	1247	5	:	:	:
cord-006860-a3b8hyyr	1247	6	C<5	C<5	NNP
cord-006860-a3b8hyyr	1247	7	%	%	NN
cord-006860-a3b8hyyr	1247	8	,	,	,
cord-006860-a3b8hyyr	1247	9	PK	PK	NNP
cord-006860-a3b8hyyr	1247	10	:	:	:
cord-006860-a3b8hyyr	1247	11	Am=5	Am=5	NNP
cord-006860-a3b8hyyr	1247	12	%	%	NN
cord-006860-a3b8hyyr	1247	13	and	and	CC
cord-006860-a3b8hyyr	1247	14	PI	PI	NNP
cord-006860-a3b8hyyr	1247	15	~	~	NFP
cord-006860-a3b8hyyr	1247	16	Ag<2.5	Ag<2.5	NNP
cord-006860-a3b8hyyr	1247	17	%	%	NN
cord-006860-a3b8hyyr	1247	18	as	as	IN
cord-006860-a3b8hyyr	1247	19	compared	compare	VBN
cord-006860-a3b8hyyr	1247	20	to	to	IN
cord-006860-a3b8hyyr	1247	21	normal	normal	JJ
cord-006860-a3b8hyyr	1247	22	pooled	pool	VBN
cord-006860-a3b8hyyr	1247	23	human	human	NN
cord-006860-a3b8hyyr	1247	24	p(asma	p(asma	NN
cord-006860-a3b8hyyr	1247	25	(	(	-LRB-
cord-006860-a3b8hyyr	1247	26	NHP	NHP	NNP
cord-006860-a3b8hyyr	1247	27	)	)	-RRB-
cord-006860-a3b8hyyr	1247	28	.	.	.
cord-006860-a3b8hyyr	1248	1	His	-PRON-	PRP$
cord-006860-a3b8hyyr	1248	2	son	son	NN
cord-006860-a3b8hyyr	1248	3	and	and	CC
cord-006860-a3b8hyyr	1248	4	two	two	CD
cord-006860-a3b8hyyr	1248	5	daughters	daughter	NNS
cord-006860-a3b8hyyr	1248	6	had	have	VBD
cord-006860-a3b8hyyr	1248	7	PK	PK	NNP
cord-006860-a3b8hyyr	1248	8	:	:	:
cord-006860-a3b8hyyr	1249	1	C-50	C-50	NNP
cord-006860-a3b8hyyr	1249	2	%	%	NN
cord-006860-a3b8hyyr	1249	3	and	and	CC
cord-006860-a3b8hyyr	1249	4	normal	normal	JJ
cord-006860-a3b8hyyr	1249	5	aPTT	aPTT	NNS
cord-006860-a3b8hyyr	1249	6	values	value	NNS
cord-006860-a3b8hyyr	1249	7	,	,	,
cord-006860-a3b8hyyr	1249	8	incubation	incubation	NN
cord-006860-a3b8hyyr	1249	9	of	of	IN
cord-006860-a3b8hyyr	1249	10	the	the	DT
cord-006860-a3b8hyyr	1249	11	propositus	propositus	NN
cord-006860-a3b8hyyr	1249	12	'	'	POS
cord-006860-a3b8hyyr	1249	13	plasma	plasma	NN
cord-006860-a3b8hyyr	1249	14	with	with	IN
cord-006860-a3b8hyyr	1249	15	DS	DS	NNP
cord-006860-a3b8hyyr	1249	16	did	do	VBD
cord-006860-a3b8hyyr	1249	17	not	not	RB
cord-006860-a3b8hyyr	1249	18	result	result	VB
cord-006860-a3b8hyyr	1249	19	in	in	IN
cord-006860-a3b8hyyr	1249	20	FXII	FXII	NNP
cord-006860-a3b8hyyr	1249	21	or	or	CC
cord-006860-a3b8hyyr	1249	22	HK	HK	NNP
cord-006860-a3b8hyyr	1249	23	cleavage	cleavage	NN
cord-006860-a3b8hyyr	1249	24	within	within	IN
cord-006860-a3b8hyyr	1249	25	180	180	CD
cord-006860-a3b8hyyr	1249	26	rain	rain	NN
cord-006860-a3b8hyyr	1249	27	,	,	,
cord-006860-a3b8hyyr	1249	28	whereas	whereas	IN
cord-006860-a3b8hyyr	1249	29	Jn	Jn	NNP
cord-006860-a3b8hyyr	1249	30	NHP	NHP	NNP
cord-006860-a3b8hyyr	1249	31	detectable	detectable	JJ
cord-006860-a3b8hyyr	1249	32	F×II	F×II	NNP
cord-006860-a3b8hyyr	1249	33	and	and	CC
cord-006860-a3b8hyyr	1249	34	HK	HK	NNP
cord-006860-a3b8hyyr	1249	35	proteolysis	proteolysis	NN
cord-006860-a3b8hyyr	1249	36	occurred	occur	VBD
cord-006860-a3b8hyyr	1249	37	after	after	IN
cord-006860-a3b8hyyr	1249	38	5	5	CD
cord-006860-a3b8hyyr	1249	39	rain	rain	NN
cord-006860-a3b8hyyr	1249	40	and	and	CC
cord-006860-a3b8hyyr	1249	41	complete	complete	JJ
cord-006860-a3b8hyyr	1249	42	proteolysis	proteolysis	NN
cord-006860-a3b8hyyr	1249	43	was	be	VBD
cord-006860-a3b8hyyr	1249	44	observed	observe	VBN
cord-006860-a3b8hyyr	1249	45	after	after	IN
cord-006860-a3b8hyyr	1249	46	-120	-120	NNP
cord-006860-a3b8hyyr	1249	47	rain	rain	NN
cord-006860-a3b8hyyr	1249	48	.	.	.
cord-006860-a3b8hyyr	1250	1	In	in	IN
cord-006860-a3b8hyyr	1250	2	contrast	contrast	NN
cord-006860-a3b8hyyr	1250	3	,	,	,
cord-006860-a3b8hyyr	1250	4	kaolin	kaolin	NN
cord-006860-a3b8hyyr	1250	5	activation	activation	NN
cord-006860-a3b8hyyr	1250	6	of	of	IN
cord-006860-a3b8hyyr	1250	7	propositus	propositus	NNP
cord-006860-a3b8hyyr	1250	8	'	'	POS
cord-006860-a3b8hyyr	1250	9	plasma	plasma	NN
cord-006860-a3b8hyyr	1250	10	led	lead	VBD
cord-006860-a3b8hyyr	1250	11	to	to	IN
cord-006860-a3b8hyyr	1250	12	slow	slow	JJ
cord-006860-a3b8hyyr	1250	13	activation	activation	NN
cord-006860-a3b8hyyr	1250	14	of	of	IN
cord-006860-a3b8hyyr	1250	15	FXII	FXII	NNP
cord-006860-a3b8hyyr	1250	16	after	after	IN
cord-006860-a3b8hyyr	1250	17	10	10	CD
cord-006860-a3b8hyyr	1250	18	rain	rain	NN
cord-006860-a3b8hyyr	1250	19	,	,	,
cord-006860-a3b8hyyr	1250	20	presumably	presumably	RB
cord-006860-a3b8hyyr	1250	21	by	by	IN
cord-006860-a3b8hyyr	1250	22	autoactivation	autoactivation	NN
cord-006860-a3b8hyyr	1250	23	,	,	,
cord-006860-a3b8hyyr	1250	24	and	and	CC
cord-006860-a3b8hyyr	1250	25	to	to	IN
cord-006860-a3b8hyyr	1250	26	FXlla	FXlla	NNP
cord-006860-a3b8hyyr	1250	27	-	-	HYPH
cord-006860-a3b8hyyr	1250	28	induced	induce	VBN
cord-006860-a3b8hyyr	1250	29	HK	HK	NNP
cord-006860-a3b8hyyr	1250	30	proteolysis	proteolysis	NN
cord-006860-a3b8hyyr	1250	31	.	.	.
cord-006860-a3b8hyyr	1251	1	Near	near	JJ
cord-006860-a3b8hyyr	1251	2	-	-	HYPH
cord-006860-a3b8hyyr	1251	3	normalization	normalization	NN
cord-006860-a3b8hyyr	1251	4	of	of	IN
cord-006860-a3b8hyyr	1251	5	the	the	DT
cord-006860-a3b8hyyr	1251	6	propositus	propositus	NN
cord-006860-a3b8hyyr	1251	7	'	'	''
cord-006860-a3b8hyyr	1252	1	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	1252	2	by	by	IN
cord-006860-a3b8hyyr	1252	3	prolongation	prolongation	NN
cord-006860-a3b8hyyr	1252	4	of	of	IN
cord-006860-a3b8hyyr	1252	5	the	the	DT
cord-006860-a3b8hyyr	1252	6	preincubation	preincubation	NN
cord-006860-a3b8hyyr	1252	7	time	time	NN
cord-006860-a3b8hyyr	1252	8	paralleled	parallel	VBD
cord-006860-a3b8hyyr	1252	9	FXII	FXII	NNP
cord-006860-a3b8hyyr	1252	10	autoactivation	autoactivation	NN
cord-006860-a3b8hyyr	1252	11	as	as	IN
cord-006860-a3b8hyyr	1252	12	evidenced	evidence	VBN
cord-006860-a3b8hyyr	1252	13	by	by	IN
cord-006860-a3b8hyyr	1252	14	immunobletting	immunoblette	VBG
cord-006860-a3b8hyyr	1252	15	.	.	.
cord-006860-a3b8hyyr	1253	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1253	2	describe	describe	VBP
cord-006860-a3b8hyyr	1253	3	a	a	DT
cord-006860-a3b8hyyr	1253	4	propositus	propositus	NN
cord-006860-a3b8hyyr	1253	5	with	with	IN
cord-006860-a3b8hyyr	1253	6	severely	severely	RB
cord-006860-a3b8hyyr	1253	7	prolonged	prolong	VBN
cord-006860-a3b8hyyr	1253	8	aPTT	aptt	NN
cord-006860-a3b8hyyr	1253	9	due	due	IN
cord-006860-a3b8hyyr	1253	10	to	to	IN
cord-006860-a3b8hyyr	1253	11	hereditary	hereditary	JJ
cord-006860-a3b8hyyr	1253	12	,	,	,
cord-006860-a3b8hyyr	1253	13	CRM	CRM	NNP
cord-006860-a3b8hyyr	1253	14	negative	negative	JJ
cord-006860-a3b8hyyr	1253	15	PK	PK	NNP
cord-006860-a3b8hyyr	1253	16	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1253	17	suffering	suffer	VBG
cord-006860-a3b8hyyr	1253	18	from	from	IN
cord-006860-a3b8hyyr	1253	19	OMF	OMF	NNP
cord-006860-a3b8hyyr	1253	20	.	.	.
cord-006860-a3b8hyyr	1254	1	Activation	activation	NN
cord-006860-a3b8hyyr	1254	2	with	with	IN
cord-006860-a3b8hyyr	1254	3	a	a	DT
cord-006860-a3b8hyyr	1254	4	particulate	particulate	NN
cord-006860-a3b8hyyr	1254	5	suspension	suspension	NN
cord-006860-a3b8hyyr	1254	6	of	of	IN
cord-006860-a3b8hyyr	1254	7	kaolin	kaolin	NN
cord-006860-a3b8hyyr	1254	8	led	lead	VBN
cord-006860-a3b8hyyr	1254	9	to	to	TO
cord-006860-a3b8hyyr	1254	10	slow	slow	VB
cord-006860-a3b8hyyr	1254	11	FXII	FXII	NNP
cord-006860-a3b8hyyr	1254	12	autoactivation	autoactivation	NN
cord-006860-a3b8hyyr	1254	13	and	and	CC
cord-006860-a3b8hyyr	1254	14	HK	HK	NNP
cord-006860-a3b8hyyr	1254	15	proteolysis	proteolysis	NN
cord-006860-a3b8hyyr	1254	16	,	,	,
cord-006860-a3b8hyyr	1254	17	whereas	whereas	IN
cord-006860-a3b8hyyr	1254	18	DS	DS	NNP
cord-006860-a3b8hyyr	1254	19	in	in	IN
cord-006860-a3b8hyyr	1254	20	solution	solution	NN
cord-006860-a3b8hyyr	1254	21	did	do	VBD
cord-006860-a3b8hyyr	1254	22	not	not	RB
cord-006860-a3b8hyyr	1254	23	induce	induce	VB
cord-006860-a3b8hyyr	1254	24	FXII	FXII	NNP
cord-006860-a3b8hyyr	1254	25	or	or	CC
cord-006860-a3b8hyyr	1254	26	HK	HK	NNP
cord-006860-a3b8hyyr	1254	27	cleavage	cleavage	NN
cord-006860-a3b8hyyr	1254	28	.	.	.
cord-006860-a3b8hyyr	1255	1	FXII	FXII	NNP
cord-006860-a3b8hyyr	1255	2	autoactivation	autoactivation	NN
cord-006860-a3b8hyyr	1255	3	seems	seem	VBZ
cord-006860-a3b8hyyr	1255	4	to	to	TO
cord-006860-a3b8hyyr	1255	5	be	be	VB
cord-006860-a3b8hyyr	1255	6	responsible	responsible	JJ
cord-006860-a3b8hyyr	1255	7	for	for	IN
cord-006860-a3b8hyyr	1255	8	the	the	DT
cord-006860-a3b8hyyr	1255	9	normalization	normalization	NN
cord-006860-a3b8hyyr	1255	10	of	of	IN
cord-006860-a3b8hyyr	1255	11	the	the	DT
cord-006860-a3b8hyyr	1255	12	prolonged	prolonged	JJ
cord-006860-a3b8hyyr	1255	13	aPTT	aptt	NN
cord-006860-a3b8hyyr	1255	14	in	in	IN
cord-006860-a3b8hyyr	1255	15	PK	PK	NNP
cord-006860-a3b8hyyr	1255	16	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1255	17	after	after	IN
cord-006860-a3b8hyyr	1255	18	prolonged	prolong	VBN
cord-006860-a3b8hyyr	1255	19	preincubation	preincubation	NN
cord-006860-a3b8hyyr	1255	20	times	time	NNS
cord-006860-a3b8hyyr	1255	21	.	.	.
cord-006860-a3b8hyyr	1256	1	In	in	IN
cord-006860-a3b8hyyr	1256	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1256	3	study	study	NN
cord-006860-a3b8hyyr	1256	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	1256	5	compared	compare	VBD
cord-006860-a3b8hyyr	1256	6	a	a	DT
cord-006860-a3b8hyyr	1256	7	conventional	conventional	JJ
cord-006860-a3b8hyyr	1256	8	bag	bag	NN
cord-006860-a3b8hyyr	1256	9	with	with	IN
cord-006860-a3b8hyyr	1256	10	silicone	silicone	NN
cord-006860-a3b8hyyr	1256	11	tubing	tubing	NN
cord-006860-a3b8hyyr	1256	12	(	(	-LRB-
cord-006860-a3b8hyyr	1256	13	A	a	NN
cord-006860-a3b8hyyr	1256	14	)	)	-RRB-
cord-006860-a3b8hyyr	1256	15	for	for	IN
cord-006860-a3b8hyyr	1256	16	blood	blood	NN
cord-006860-a3b8hyyr	1256	17	donation	donation	NN
cord-006860-a3b8hyyr	1256	18	with	with	IN
cord-006860-a3b8hyyr	1256	19	2	2	CD
cord-006860-a3b8hyyr	1256	20	new	new	JJ
cord-006860-a3b8hyyr	1256	21	ones	one	NNS
cord-006860-a3b8hyyr	1256	22	(	(	-LRB-
cord-006860-a3b8hyyr	1256	23	]	]	-RRB-
cord-006860-a3b8hyyr	1256	24	3	3	CD
cord-006860-a3b8hyyr	1256	25	from	from	IN
cord-006860-a3b8hyyr	1256	26	Biotrans	Biotrans	NNPS
cord-006860-a3b8hyyr	1256	27	and	and	CC
cord-006860-a3b8hyyr	1256	28	C	C	NNP
cord-006860-a3b8hyyr	1256	29	from	from	IN
cord-006860-a3b8hyyr	1256	30	Baxter	Baxter	NNP
cord-006860-a3b8hyyr	1256	31	)	)	-RRB-
cord-006860-a3b8hyyr	1256	32	with	with	IN
cord-006860-a3b8hyyr	1256	33	a	a	DT
cord-006860-a3b8hyyr	1256	34	newly	newly	RB
cord-006860-a3b8hyyr	1256	35	developed	develop	VBN
cord-006860-a3b8hyyr	1256	36	Y	Y	NNP
cord-006860-a3b8hyyr	1256	37	-	-	HYPH
cord-006860-a3b8hyyr	1256	38	shaped	shape	VBN
cord-006860-a3b8hyyr	1256	39	adapter	adapter	NN
cord-006860-a3b8hyyr	1256	40	.	.	.
cord-006860-a3b8hyyr	1257	1	This	this	DT
cord-006860-a3b8hyyr	1257	2	adapter	adapter	NN
cord-006860-a3b8hyyr	1257	3	is	be	VBZ
cord-006860-a3b8hyyr	1257	4	integrated	integrate	VBN
cord-006860-a3b8hyyr	1257	5	into	into	IN
cord-006860-a3b8hyyr	1257	6	the	the	DT
cord-006860-a3b8hyyr	1257	7	tubing	tubing	NN
cord-006860-a3b8hyyr	1257	8	and	and	CC
cord-006860-a3b8hyyr	1257	9	therefore	therefore	RB
cord-006860-a3b8hyyr	1257	10	provides	provide	VBZ
cord-006860-a3b8hyyr	1257	11	the	the	DT
cord-006860-a3b8hyyr	1257	12	advantage	advantage	NN
cord-006860-a3b8hyyr	1257	13	for	for	IN
cord-006860-a3b8hyyr	1257	14	drawing	draw	VBG
cord-006860-a3b8hyyr	1257	15	blood	blood	NN
cord-006860-a3b8hyyr	1257	16	samples	sample	NNS
cord-006860-a3b8hyyr	1257	17	in	in	IN
cord-006860-a3b8hyyr	1257	18	a	a	DT
cord-006860-a3b8hyyr	1257	19	closed	closed	JJ
cord-006860-a3b8hyyr	1257	20	system	system	NN
cord-006860-a3b8hyyr	1257	21	.	.	.
cord-006860-a3b8hyyr	1258	1	The	the	DT
cord-006860-a3b8hyyr	1258	2	3	3	CD
cord-006860-a3b8hyyr	1258	3	systems	system	NNS
cord-006860-a3b8hyyr	1258	4	were	be	VBD
cord-006860-a3b8hyyr	1258	5	identical	identical	JJ
cord-006860-a3b8hyyr	1258	6	in	in	IN
cord-006860-a3b8hyyr	1258	7	amount	amount	NN
cord-006860-a3b8hyyr	1258	8	and	and	CC
cord-006860-a3b8hyyr	1258	9	content	content	NN
cord-006860-a3b8hyyr	1258	10	of	of	IN
cord-006860-a3b8hyyr	1258	11	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	1258	12	,	,	,
cord-006860-a3b8hyyr	1258	13	i.	i.	NNP
cord-006860-a3b8hyyr	1258	14	e.	e.	NNP
cord-006860-a3b8hyyr	1258	15	63	63	CD
cord-006860-a3b8hyyr	1258	16	ml	ml	NNS
cord-006860-a3b8hyyr	1258	17	of	of	IN
cord-006860-a3b8hyyr	1258	18	CPD	CPD	NNP
cord-006860-a3b8hyyr	1258	19	per	per	IN
cord-006860-a3b8hyyr	1258	20	bag	bag	NN
cord-006860-a3b8hyyr	1258	21	resulting	result	VBG
cord-006860-a3b8hyyr	1258	22	in	in	IN
cord-006860-a3b8hyyr	1258	23	approximately	approximately	RB
cord-006860-a3b8hyyr	1258	24	14	14	CD
cord-006860-a3b8hyyr	1258	25	%	%	NN
cord-006860-a3b8hyyr	1258	26	of	of	IN
cord-006860-a3b8hyyr	1258	27	the	the	DT
cord-006860-a3b8hyyr	1258	28	final	final	JJ
cord-006860-a3b8hyyr	1258	29	whole	whole	JJ
cord-006860-a3b8hyyr	1258	30	blood	blood	NN
cord-006860-a3b8hyyr	1258	31	volume	volume	NN
cord-006860-a3b8hyyr	1258	32	.	.	.
cord-006860-a3b8hyyr	1259	1	The	the	DT
cord-006860-a3b8hyyr	1259	2	purpose	purpose	NN
cord-006860-a3b8hyyr	1259	3	of	of	IN
cord-006860-a3b8hyyr	1259	4	the	the	DT
cord-006860-a3b8hyyr	1259	5	study	study	NN
cord-006860-a3b8hyyr	1259	6	was	be	VBD
cord-006860-a3b8hyyr	1259	7	to	to	TO
cord-006860-a3b8hyyr	1259	8	determine	determine	VB
cord-006860-a3b8hyyr	1259	9	whether	whether	IN
cord-006860-a3b8hyyr	1259	10	the	the	DT
cord-006860-a3b8hyyr	1259	11	different	different	JJ
cord-006860-a3b8hyyr	1259	12	tubings	tubing	NNS
cord-006860-a3b8hyyr	1259	13	can	can	MD
cord-006860-a3b8hyyr	1259	14	influence	influence	VB
cord-006860-a3b8hyyr	1259	15	the	the	DT
cord-006860-a3b8hyyr	1259	16	quality	quality	NN
cord-006860-a3b8hyyr	1259	17	of	of	IN
cord-006860-a3b8hyyr	1259	18	plasma	plasma	NN
cord-006860-a3b8hyyr	1259	19	products	product	NNS
cord-006860-a3b8hyyr	1259	20	conceming	conceme	VBG
cord-006860-a3b8hyyr	1259	21	the	the	DT
cord-006860-a3b8hyyr	1259	22	blood	blood	NN
cord-006860-a3b8hyyr	1259	23	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1259	24	system	system	NN
cord-006860-a3b8hyyr	1259	25	.	.	.
cord-006860-a3b8hyyr	1260	1	In	in	IN
cord-006860-a3b8hyyr	1260	2	plasma	plasma	NN
cord-006860-a3b8hyyr	1260	3	samples	sample	NNS
cord-006860-a3b8hyyr	1260	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	1260	5	measured	measure	VBD
cord-006860-a3b8hyyr	1260	6	several	several	JJ
cord-006860-a3b8hyyr	1260	7	factors	factor	NNS
cord-006860-a3b8hyyr	1260	8	of	of	IN
cord-006860-a3b8hyyr	1260	9	the	the	DT
cord-006860-a3b8hyyr	1260	10	procoagnlatory	procoagnlatory	JJ
cord-006860-a3b8hyyr	1260	11	and	and	CC
cord-006860-a3b8hyyr	1260	12	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1260	13	systems	system	NNS
cord-006860-a3b8hyyr	1260	14	.	.	.
cord-006860-a3b8hyyr	1261	1	Intralndividual	Intralndividual	NNP
cord-006860-a3b8hyyr	1261	2	control	control	NN
cord-006860-a3b8hyyr	1261	3	eitrated	eitrated	NNP
cord-006860-a3b8hyyr	1261	4	(	(	-LRB-
cord-006860-a3b8hyyr	1261	5	.135	.135	CD
cord-006860-a3b8hyyr	1261	6	M	M	NNP
cord-006860-a3b8hyyr	1261	7	)	)	-RRB-
cord-006860-a3b8hyyr	1261	8	blood	blood	NN
cord-006860-a3b8hyyr	1261	9	samples	sample	NNS
cord-006860-a3b8hyyr	1261	10	were	be	VBD
cord-006860-a3b8hyyr	1261	11	initially	initially	RB
cord-006860-a3b8hyyr	1261	12	drawn	draw	VBN
cord-006860-a3b8hyyr	1261	13	from	from	IN
cord-006860-a3b8hyyr	1261	14	the	the	DT
cord-006860-a3b8hyyr	1261	15	contralateral	contralateral	JJ
cord-006860-a3b8hyyr	1261	16	cubital	cubital	JJ
cord-006860-a3b8hyyr	1261	17	vein	vein	NN
cord-006860-a3b8hyyr	1261	18	from	from	IN
cord-006860-a3b8hyyr	1261	19	the	the	DT
cord-006860-a3b8hyyr	1261	20	same	same	JJ
cord-006860-a3b8hyyr	1261	21	male	male	JJ
cord-006860-a3b8hyyr	1261	22	donor	donor	NN
cord-006860-a3b8hyyr	1261	23	(	(	-LRB-
cord-006860-a3b8hyyr	1261	24	34	34	CD
cord-006860-a3b8hyyr	1261	25	in	in	IN
cord-006860-a3b8hyyr	1261	26	each	each	DT
cord-006860-a3b8hyyr	1261	27	group	group	NN
cord-006860-a3b8hyyr	1261	28	)	)	-RRB-
cord-006860-a3b8hyyr	1261	29	.	.	.
cord-006860-a3b8hyyr	1262	1	In	in	IN
cord-006860-a3b8hyyr	1262	2	all	all	DT
cord-006860-a3b8hyyr	1262	3	bag	bag	NN
cord-006860-a3b8hyyr	1262	4	samples	sample	NNS
cord-006860-a3b8hyyr	1262	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	1262	6	found	find	VBD
cord-006860-a3b8hyyr	1262	7	small	small	JJ
cord-006860-a3b8hyyr	1262	8	but	but	CC
cord-006860-a3b8hyyr	1262	9	significantly	significantly	RB
cord-006860-a3b8hyyr	1262	10	higher	high	JJR
cord-006860-a3b8hyyr	1262	11	levels	level	NNS
cord-006860-a3b8hyyr	1262	12	of	of	IN
cord-006860-a3b8hyyr	1262	13	the	the	DT
cord-006860-a3b8hyyr	1262	14	global	global	JJ
cord-006860-a3b8hyyr	1262	15	test	test	NN
cord-006860-a3b8hyyr	1262	16	parameters	parameter	NNS
cord-006860-a3b8hyyr	1262	17	aP'IT	aP'IT	NNP
cord-006860-a3b8hyyr	1262	18	and	and	CC
cord-006860-a3b8hyyr	1262	19	TI	TI	NNP
cord-006860-a3b8hyyr	1262	20	"	"	''
cord-006860-a3b8hyyr	1262	21	compared	compare	VBN
cord-006860-a3b8hyyr	1262	22	to	to	IN
cord-006860-a3b8hyyr	1262	23	controls	control	NNS
cord-006860-a3b8hyyr	1262	24	,	,	,
cord-006860-a3b8hyyr	1262	25	indicating	indicate	VBG
cord-006860-a3b8hyyr	1262	26	a	a	DT
cord-006860-a3b8hyyr	1262	27	higher	high	JJR
cord-006860-a3b8hyyr	1262	28	amount	amount	NN
cord-006860-a3b8hyyr	1262	29	of	of	IN
cord-006860-a3b8hyyr	1262	30	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	1262	31	.	.	.
cord-006860-a3b8hyyr	1263	1	PT	PT	NNP
cord-006860-a3b8hyyr	1263	2	,	,	,
cord-006860-a3b8hyyr	1263	3	however	however	RB
cord-006860-a3b8hyyr	1263	4	,	,	,
cord-006860-a3b8hyyr	1263	5	revealed	reveal	VBD
cord-006860-a3b8hyyr	1263	6	no	no	DT
cord-006860-a3b8hyyr	1263	7	differences	difference	NNS
cord-006860-a3b8hyyr	1263	8	,	,	,
cord-006860-a3b8hyyr	1263	9	thus	thus	RB
cord-006860-a3b8hyyr	1263	10	suggesting	suggest	VBG
cord-006860-a3b8hyyr	1263	11	that	that	IN
cord-006860-a3b8hyyr	1263	12	factor	factor	NN
cord-006860-a3b8hyyr	1263	13	activities	activity	NNS
cord-006860-a3b8hyyr	1263	14	were	be	VBD
cord-006860-a3b8hyyr	1263	15	not	not	RB
cord-006860-a3b8hyyr	1263	16	altered	alter	VBN
cord-006860-a3b8hyyr	1263	17	(	(	-LRB-
cord-006860-a3b8hyyr	1263	18	statistics	statistic	NNS
cord-006860-a3b8hyyr	1263	19	according	accord	VBG
cord-006860-a3b8hyyr	1263	20	to	to	IN
cord-006860-a3b8hyyr	1263	21	Mann	Mann	NNP
cord-006860-a3b8hyyr	1263	22	-	-	HYPH
cord-006860-a3b8hyyr	1263	23	Whimey	Whimey	NNP
cord-006860-a3b8hyyr	1263	24	)	)	-RRB-
cord-006860-a3b8hyyr	1263	25	.	.	.
cord-006860-a3b8hyyr	1264	1	Increase	increase	NN
cord-006860-a3b8hyyr	1264	2	of	of	IN
cord-006860-a3b8hyyr	1264	3	procoagulatory	procoagulatory	JJ
cord-006860-a3b8hyyr	1264	4	activity	activity	NN
cord-006860-a3b8hyyr	1264	5	measured	measure	VBN
cord-006860-a3b8hyyr	1264	6	as	as	IN
cord-006860-a3b8hyyr	1264	7	TAT	TAT	NNP
cord-006860-a3b8hyyr	1264	8	complexes	complex	NNS
cord-006860-a3b8hyyr	1264	9	showed	show	VBD
cord-006860-a3b8hyyr	1264	10	elevated	elevated	JJ
cord-006860-a3b8hyyr	1264	11	levels	level	NNS
cord-006860-a3b8hyyr	1264	12	in	in	IN
cord-006860-a3b8hyyr	1264	13	bags	bag	NNS
cord-006860-a3b8hyyr	1264	14	A	a	NN
cord-006860-a3b8hyyr	1264	15	and	and	CC
cord-006860-a3b8hyyr	1264	16	C	c	NN
cord-006860-a3b8hyyr	1264	17	whereas	whereas	IN
cord-006860-a3b8hyyr	1264	18	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	1264	19	fragments	fragment	NNS
cord-006860-a3b8hyyr	1264	20	Fl+2	Fl+2	NNS
cord-006860-a3b8hyyr	1264	21	decreased	decrease	VBD
cord-006860-a3b8hyyr	1264	22	only	only	RB
cord-006860-a3b8hyyr	1264	23	in	in	IN
cord-006860-a3b8hyyr	1264	24	A.	a.	NN
cord-006860-a3b8hyyr	1264	25	Conceming	Conceming	NNP
cord-006860-a3b8hyyr	1264	26	the	the	DT
cord-006860-a3b8hyyr	1264	27	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1264	28	system	system	NN
cord-006860-a3b8hyyr	1264	29	,	,	,
cord-006860-a3b8hyyr	1264	30	plasminogen	plasminogen	VB
cord-006860-a3b8hyyr	1264	31	a	a	DT
cord-006860-a3b8hyyr	1264	32	~	~	CD
cord-006860-a3b8hyyr	1264	33	tivators	tivator	NNS
cord-006860-a3b8hyyr	1264	34	and	and	CC
cord-006860-a3b8hyyr	1264	35	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	1264	36	values	value	NNS
cord-006860-a3b8hyyr	1264	37	were	be	VBD
cord-006860-a3b8hyyr	1264	38	diminished	diminish	VBN
cord-006860-a3b8hyyr	1264	39	in	in	IN
cord-006860-a3b8hyyr	1264	40	all	all	DT
cord-006860-a3b8hyyr	1264	41	three	three	CD
cord-006860-a3b8hyyr	1264	42	systems	system	NNS
cord-006860-a3b8hyyr	1264	43	03	03	CD
cord-006860-a3b8hyyr	1264	44	<	<	XX
cord-006860-a3b8hyyr	1264	45	A	a	DT
cord-006860-a3b8hyyr	1264	46	<	<	XX
cord-006860-a3b8hyyr	1264	47	C	C	NNP
cord-006860-a3b8hyyr	1264	48	)	)	-RRB-
cord-006860-a3b8hyyr	1264	49	compared	compare	VBN
cord-006860-a3b8hyyr	1264	50	to	to	IN
cord-006860-a3b8hyyr	1264	51	controls	control	NNS
cord-006860-a3b8hyyr	1264	52	.	.	.
cord-006860-a3b8hyyr	1265	1	D	D	NNS
cord-006860-a3b8hyyr	1265	2	-	-	HYPH
cord-006860-a3b8hyyr	1265	3	dimers	dimer	NNS
cord-006860-a3b8hyyr	1265	4	were	be	VBD
cord-006860-a3b8hyyr	1265	5	lowest	low	JJS
cord-006860-a3b8hyyr	1265	6	in	in	IN
cord-006860-a3b8hyyr	1265	7	A	a	DT
cord-006860-a3b8hyyr	1265	8	followed	follow	VBN
cord-006860-a3b8hyyr	1265	9	by	by	IN
cord-006860-a3b8hyyr	1265	10	slightly	slightly	RB
cord-006860-a3b8hyyr	1265	11	higher	high	JJR
cord-006860-a3b8hyyr	1265	12	values	value	NNS
cord-006860-a3b8hyyr	1265	13	in	in	IN
cord-006860-a3b8hyyr	1265	14	C	C	NNP
cord-006860-a3b8hyyr	1265	15	,	,	,
cord-006860-a3b8hyyr	1265	16	controls	control	NNS
cord-006860-a3b8hyyr	1265	17	and	and	CC
cord-006860-a3b8hyyr	1265	18	B.	B.	NNP
cord-006860-a3b8hyyr	1265	19	Fibrin	Fibrin	NNP
cord-006860-a3b8hyyr	1265	20	monomers	monomer	NNS
cord-006860-a3b8hyyr	1265	21	did	do	VBD
cord-006860-a3b8hyyr	1265	22	not	not	RB
cord-006860-a3b8hyyr	1265	23	reveal	reveal	VB
cord-006860-a3b8hyyr	1265	24	any	any	DT
cord-006860-a3b8hyyr	1265	25	significant	significant	JJ
cord-006860-a3b8hyyr	1265	26	differences	difference	NNS
cord-006860-a3b8hyyr	1265	27	:	:	:
cord-006860-a3b8hyyr	1266	1	A	a	DT
cord-006860-a3b8hyyr	1266	2	<	<	XX
cord-006860-a3b8hyyr	1266	3	C	c	NN
cord-006860-a3b8hyyr	1266	4	<	<	XX
cord-006860-a3b8hyyr	1266	5	controls	control	VBZ
cord-006860-a3b8hyyr	1266	6	<	<	XX
cord-006860-a3b8hyyr	1266	7	B.	B.	NNP
cord-006860-a3b8hyyr	1267	1	In	in	IN
cord-006860-a3b8hyyr	1267	2	summary	summary	NN
cord-006860-a3b8hyyr	1267	3	,	,	,
cord-006860-a3b8hyyr	1267	4	the	the	DT
cord-006860-a3b8hyyr	1267	5	quality	quality	NN
cord-006860-a3b8hyyr	1267	6	,	,	,
cord-006860-a3b8hyyr	1267	7	of	of	IN
cord-006860-a3b8hyyr	1267	8	the	the	DT
cord-006860-a3b8hyyr	1267	9	3	3	CD
cord-006860-a3b8hyyr	1267	10	different	different	JJ
cord-006860-a3b8hyyr	1267	11	blood	blood	NN
cord-006860-a3b8hyyr	1267	12	sampling	sampling	NN
cord-006860-a3b8hyyr	1267	13	devices	device	NNS
cord-006860-a3b8hyyr	1267	14	was	be	VBD
cord-006860-a3b8hyyr	1267	15	comparable	comparable	JJ
cord-006860-a3b8hyyr	1267	16	to	to	IN
cord-006860-a3b8hyyr	1267	17	the	the	DT
cord-006860-a3b8hyyr	1267	18	intraindividual	intraindividual	NNP
cord-006860-a3b8hyyr	1267	19	controls	control	NNS
cord-006860-a3b8hyyr	1267	20	as	as	IN
cord-006860-a3b8hyyr	1267	21	to	to	IN
cord-006860-a3b8hyyr	1267	22	factor	factor	NN
cord-006860-a3b8hyyr	1267	23	activities	activity	NNS
cord-006860-a3b8hyyr	1267	24	measured	measure	VBN
cord-006860-a3b8hyyr	1267	25	by	by	IN
cord-006860-a3b8hyyr	1267	26	global	global	JJ
cord-006860-a3b8hyyr	1267	27	tests	test	NNS
cord-006860-a3b8hyyr	1267	28	.	.	.
cord-006860-a3b8hyyr	1268	1	The	the	DT
cord-006860-a3b8hyyr	1268	2	activation	activation	NN
cord-006860-a3b8hyyr	1268	3	of	of	IN
cord-006860-a3b8hyyr	1268	4	the	the	DT
cord-006860-a3b8hyyr	1268	5	procoagulatory	procoagulatory	JJ
cord-006860-a3b8hyyr	1268	6	and	and	CC
cord-006860-a3b8hyyr	1268	7	fibrinotytic	fibrinotytic	NNP
cord-006860-a3b8hyyr	1268	8	systems	system	NNS
cord-006860-a3b8hyyr	1268	9	was	be	VBD
cord-006860-a3b8hyyr	1268	10	slightly	slightly	RB
cord-006860-a3b8hyyr	1268	11	but	but	CC
cord-006860-a3b8hyyr	1268	12	in	in	IN
cord-006860-a3b8hyyr	1268	13	most	most	JJS
cord-006860-a3b8hyyr	1268	14	cases	case	NNS
cord-006860-a3b8hyyr	1268	15	significantly	significantly	RB
cord-006860-a3b8hyyr	1268	16	higher	high	JJR
cord-006860-a3b8hyyr	1268	17	in	in	IN
cord-006860-a3b8hyyr	1268	18	the	the	DT
cord-006860-a3b8hyyr	1268	19	two	two	CD
cord-006860-a3b8hyyr	1268	20	new	new	JJ
cord-006860-a3b8hyyr	1268	21	devices	device	NNS
cord-006860-a3b8hyyr	1268	22	than	than	IN
cord-006860-a3b8hyyr	1268	23	in	in	IN
cord-006860-a3b8hyyr	1268	24	the	the	DT
cord-006860-a3b8hyyr	1268	25	conventional	conventional	JJ
cord-006860-a3b8hyyr	1268	26	one	one	CD
cord-006860-a3b8hyyr	1268	27	.	.	.
cord-006860-a3b8hyyr	1269	1	All	all	DT
cord-006860-a3b8hyyr	1269	2	values	value	NNS
cord-006860-a3b8hyyr	1269	3	,	,	,
cord-006860-a3b8hyyr	1269	4	however	however	RB
cord-006860-a3b8hyyr	1269	5	,	,	,
cord-006860-a3b8hyyr	1269	6	obtained	obtain	VBN
cord-006860-a3b8hyyr	1269	7	from	from	IN
cord-006860-a3b8hyyr	1269	8	the	the	DT
cord-006860-a3b8hyyr	1269	9	plasma	plasma	NN
cord-006860-a3b8hyyr	1269	10	samples	sample	NNS
cord-006860-a3b8hyyr	1269	11	did	do	VBD
cord-006860-a3b8hyyr	1269	12	not	not	RB
cord-006860-a3b8hyyr	1269	13	exceed	exceed	VB
cord-006860-a3b8hyyr	1269	14	the	the	DT
cord-006860-a3b8hyyr	1269	15	normal	normal	JJ
cord-006860-a3b8hyyr	1269	16	range	range	NN
cord-006860-a3b8hyyr	1269	17	of	of	IN
cord-006860-a3b8hyyr	1269	18	healthy	healthy	JJ
cord-006860-a3b8hyyr	1269	19	blood	blood	NN
cord-006860-a3b8hyyr	1269	20	donors	donor	NNS
cord-006860-a3b8hyyr	1269	21	.	.	.
cord-006860-a3b8hyyr	1270	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	1270	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	1270	3	concluded	conclude	VBD
cord-006860-a3b8hyyr	1270	4	that	that	IN
cord-006860-a3b8hyyr	1270	5	the	the	DT
cord-006860-a3b8hyyr	1270	6	two	two	CD
cord-006860-a3b8hyyr	1270	7	new	new	JJ
cord-006860-a3b8hyyr	1270	8	closed	closed	JJ
cord-006860-a3b8hyyr	1270	9	blood	blood	NN
cord-006860-a3b8hyyr	1270	10	drawing	drawing	NN
cord-006860-a3b8hyyr	1270	11	systems	system	NNS
cord-006860-a3b8hyyr	1270	12	are	be	VBP
cord-006860-a3b8hyyr	1270	13	favorable	favorable	JJ
cord-006860-a3b8hyyr	1270	14	for	for	IN
cord-006860-a3b8hyyr	1270	15	blood	blood	NN
cord-006860-a3b8hyyr	1270	16	donating	donate	VBG
cord-006860-a3b8hyyr	1270	17	procedures	procedure	NNS
cord-006860-a3b8hyyr	1270	18	.	.	.
cord-006860-a3b8hyyr	1271	1	In	in	IN
cord-006860-a3b8hyyr	1271	2	20	20	CD
cord-006860-a3b8hyyr	1271	3	patients	patient	NNS
cord-006860-a3b8hyyr	1271	4	with	with	IN
cord-006860-a3b8hyyr	1271	5	acute	acute	JJ
cord-006860-a3b8hyyr	1271	6	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	1271	7	infarction	infarction	NN
cord-006860-a3b8hyyr	1271	8	(	(	-LRB-
cord-006860-a3b8hyyr	1271	9	AMI	AMI	NNP
cord-006860-a3b8hyyr	1271	10	)	)	-RRB-
cord-006860-a3b8hyyr	1271	11	and	and	CC
cord-006860-a3b8hyyr	1271	12	thromholytie	thromholytie	NN
cord-006860-a3b8hyyr	1271	13	therapy	therapy	NN
cord-006860-a3b8hyyr	1271	14	(	(	-LRB-
cord-006860-a3b8hyyr	1271	15	13	13	CD
cord-006860-a3b8hyyr	1271	16	patients	patient	NNS
cord-006860-a3b8hyyr	1271	17	with	with	IN
cord-006860-a3b8hyyr	1271	18	rt	rt	NNP
cord-006860-a3b8hyyr	1271	19	-	-	HYPH
cord-006860-a3b8hyyr	1271	20	PA	PA	NNP
cord-006860-a3b8hyyr	1271	21	,	,	,
cord-006860-a3b8hyyr	1271	22	6	6	CD
cord-006860-a3b8hyyr	1271	23	patients	patient	NNS
cord-006860-a3b8hyyr	1271	24	with	with	IN
cord-006860-a3b8hyyr	1271	25	streptokinase	streptokinase	NNP
cord-006860-a3b8hyyr	1271	26	and	and	CC
cord-006860-a3b8hyyr	1271	27	one	one	CD
cord-006860-a3b8hyyr	1271	28	with	with	IN
cord-006860-a3b8hyyr	1271	29	heparln	heparln	NNP
cord-006860-a3b8hyyr	1271	30	)	)	-RRB-
cord-006860-a3b8hyyr	1271	31	with	with	IN
cord-006860-a3b8hyyr	1271	32	CK	CK	NNP
cord-006860-a3b8hyyr	1271	33	,	,	,
cord-006860-a3b8hyyr	1271	34	myoglobin	myoglobin	NN
cord-006860-a3b8hyyr	1271	35	and	and	CC
cord-006860-a3b8hyyr	1271	36	EKG	EKG	NNP
cord-006860-a3b8hyyr	1271	37	criterions	criterion	NNS
cord-006860-a3b8hyyr	1271	38	the	the	DT
cord-006860-a3b8hyyr	1271	39	patients	patient	NNS
cord-006860-a3b8hyyr	1271	40	were	be	VBD
cord-006860-a3b8hyyr	1271	41	divided	divide	VBN
cord-006860-a3b8hyyr	1271	42	in	in	IN
cord-006860-a3b8hyyr	1271	43	two	two	CD
cord-006860-a3b8hyyr	1271	44	groups	group	NNS
cord-006860-a3b8hyyr	1271	45	(	(	-LRB-
cord-006860-a3b8hyyr	1271	46	reperfusion	reperfusion	NN
cord-006860-a3b8hyyr	1271	47	/	/	SYM
cord-006860-a3b8hyyr	1271	48	no	no	DT
cord-006860-a3b8hyyr	1271	49	fellow	fellow	JJ
cord-006860-a3b8hyyr	1271	50	two	two	CD
cord-006860-a3b8hyyr	1271	51	hours	hour	NNS
cord-006860-a3b8hyyr	1271	52	after	after	IN
cord-006860-a3b8hyyr	1271	53	starting	start	VBG
cord-006860-a3b8hyyr	1271	54	the	the	DT
cord-006860-a3b8hyyr	1271	55	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	1271	56	therapy	therapy	NN
cord-006860-a3b8hyyr	1271	57	)	)	-RRB-
cord-006860-a3b8hyyr	1271	58	.	.	.
cord-006860-a3b8hyyr	1272	1	Blood	blood	NN
cord-006860-a3b8hyyr	1272	2	samples	sample	NNS
cord-006860-a3b8hyyr	1272	3	were	be	VBD
cord-006860-a3b8hyyr	1272	4	taken	take	VBN
cord-006860-a3b8hyyr	1272	5	before	before	RB
cord-006860-a3b8hyyr	1272	6	,	,	,
cord-006860-a3b8hyyr	1272	7	30	30	CD
cord-006860-a3b8hyyr	1272	8	rain	rain	NN
cord-006860-a3b8hyyr	1272	9	,	,	,
cord-006860-a3b8hyyr	1272	10	I	-PRON-	PRP
cord-006860-a3b8hyyr	1272	11	h	h	NNP
cord-006860-a3b8hyyr	1272	12	,	,	,
cord-006860-a3b8hyyr	1272	13	2	2	CD
cord-006860-a3b8hyyr	1272	14	h	h	NN
cord-006860-a3b8hyyr	1272	15	,	,	,
cord-006860-a3b8hyyr	1272	16	4	4	CD
cord-006860-a3b8hyyr	1272	17	h	h	NN
cord-006860-a3b8hyyr	1272	18	,	,	,
cord-006860-a3b8hyyr	1272	19	8	8	CD
cord-006860-a3b8hyyr	1272	20	h,12	h,12	NN
cord-006860-a3b8hyyr	1272	21	h	h	NN
cord-006860-a3b8hyyr	1272	22	after	after	IN
cord-006860-a3b8hyyr	1272	23	lysis	lysis	NN
cord-006860-a3b8hyyr	1272	24	and	and	CC
cord-006860-a3b8hyyr	1272	25	than	than	IN
cord-006860-a3b8hyyr	1272	26	every	every	DT
cord-006860-a3b8hyyr	1272	27	day	day	NN
cord-006860-a3b8hyyr	1272	28	till	till	IN
cord-006860-a3b8hyyr	1272	29	day	day	NN
cord-006860-a3b8hyyr	1272	30	10	10	CD
cord-006860-a3b8hyyr	1272	31	.	.	.
cord-006860-a3b8hyyr	1273	1	Because	because	IN
cord-006860-a3b8hyyr	1273	2	of	of	IN
cord-006860-a3b8hyyr	1273	3	the	the	DT
cord-006860-a3b8hyyr	1273	4	central	central	JJ
cord-006860-a3b8hyyr	1273	5	role	role	NN
cord-006860-a3b8hyyr	1273	6	of	of	IN
cord-006860-a3b8hyyr	1273	7	factor	factor	NN
cord-006860-a3b8hyyr	1273	8	XII	XII	NNP
cord-006860-a3b8hyyr	1273	9	in	in	IN
cord-006860-a3b8hyyr	1273	10	activation	activation	NN
cord-006860-a3b8hyyr	1273	11	of	of	IN
cord-006860-a3b8hyyr	1273	12	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1273	13	,	,	,
cord-006860-a3b8hyyr	1273	14	fibrinolysis	fibrinolysis	NNP
cord-006860-a3b8hyyr	1273	15	,	,	,
cord-006860-a3b8hyyr	1273	16	kallikreln	kallikreln	NNP
cord-006860-a3b8hyyr	1273	17	-	-	HYPH
cord-006860-a3b8hyyr	1273	18	kinin	kinin	NN
cord-006860-a3b8hyyr	1273	19	-	-	HYPH
cord-006860-a3b8hyyr	1273	20	system	system	NN
cord-006860-a3b8hyyr	1273	21	and	and	CC
cord-006860-a3b8hyyr	1273	22	complement	complement	NN
cord-006860-a3b8hyyr	1273	23	cascade	cascade	NN
cord-006860-a3b8hyyr	1273	24	we	-PRON-	PRP
cord-006860-a3b8hyyr	1273	25	investlgate	investlgate	VBP
cord-006860-a3b8hyyr	1273	26	the	the	DT
cord-006860-a3b8hyyr	1273	27	role	role	NN
cord-006860-a3b8hyyr	1273	28	of	of	IN
cord-006860-a3b8hyyr	1273	29	factor	factor	NN
cord-006860-a3b8hyyr	1273	30	XIla	XIla	NNP
cord-006860-a3b8hyyr	1273	31	initiated	initiate	VBN
cord-006860-a3b8hyyr	1273	32	by	by	IN
cord-006860-a3b8hyyr	1273	33	AMI	AMI	NNP
cord-006860-a3b8hyyr	1273	34	and	and	CC
cord-006860-a3b8hyyr	1273	35	the	the	DT
cord-006860-a3b8hyyr	1273	36	relation	relation	NN
cord-006860-a3b8hyyr	1273	37	of	of	IN
cord-006860-a3b8hyyr	1273	38	factor	factor	NN
cord-006860-a3b8hyyr	1273	39	XIIa	XIIa	NNS
cord-006860-a3b8hyyr	1273	40	to	to	IN
cord-006860-a3b8hyyr	1273	41	the	the	DT
cord-006860-a3b8hyyr	1273	42	thrombolytie	thrombolytie	NN
cord-006860-a3b8hyyr	1273	43	agent	agent	NN
cord-006860-a3b8hyyr	1273	44	and	and	CC
cord-006860-a3b8hyyr	1273	45	reoeclusion	reoeclusion	NN
cord-006860-a3b8hyyr	1273	46	rate	rate	NN
cord-006860-a3b8hyyr	1273	47	.	.	.
cord-006860-a3b8hyyr	1274	1	For	for	IN
cord-006860-a3b8hyyr	1274	2	the	the	DT
cord-006860-a3b8hyyr	1274	3	investigatlens	investigatlen	NNS
cord-006860-a3b8hyyr	1274	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	1274	5	take	take	VBP
cord-006860-a3b8hyyr	1274	6	the	the	DT
cord-006860-a3b8hyyr	1274	7	kits	kit	NNS
cord-006860-a3b8hyyr	1274	8	from	from	IN
cord-006860-a3b8hyyr	1274	9	SHIELD	SHIELD	NNP
cord-006860-a3b8hyyr	1274	10	DIAGNOSTICS	DIAGNOSTICS	NNP
cord-006860-a3b8hyyr	1274	11	(	(	-LRB-
cord-006860-a3b8hyyr	1274	12	XIIa	XIIa	NNP
cord-006860-a3b8hyyr	1274	13	)	)	-RRB-
cord-006860-a3b8hyyr	1274	14	,	,	,
cord-006860-a3b8hyyr	1274	15	Behring	Behring	NNP
cord-006860-a3b8hyyr	1274	16	Diagnostica	Diagnostica	NNP
cord-006860-a3b8hyyr	1274	17	(	(	-LRB-
cord-006860-a3b8hyyr	1274	18	C~-Inactivator	C~-Inactivator	NNP
cord-006860-a3b8hyyr	1274	19	,	,	,
cord-006860-a3b8hyyr	1274	20	pl	pl	NNP
cord-006860-a3b8hyyr	1274	21	~	~	NNP
cord-006860-a3b8hyyr	1274	22	nogen	nogen	NNP
cord-006860-a3b8hyyr	1274	23	,	,	,
cord-006860-a3b8hyyr	1274	24	~-antip]~n~	~-antip]~n~	NNP
cord-006860-a3b8hyyr	1275	1	n	n	CC
cord-006860-a3b8hyyr	1275	2	,	,	,
cord-006860-a3b8hyyr	1275	3	PAP	PAP	NNP
cord-006860-a3b8hyyr	1275	4	)	)	-RRB-
cord-006860-a3b8hyyr	1275	5	,	,	,
cord-006860-a3b8hyyr	1275	6	Chromogefiilx	Chromogefiilx	NNP
cord-006860-a3b8hyyr	1275	7	AB	AB	NNP
cord-006860-a3b8hyyr	1275	8	(	(	-LRB-
cord-006860-a3b8hyyr	1275	9	prekallikrein	prekallikrein	NNP
cord-006860-a3b8hyyr	1275	10	)	)	-RRB-
cord-006860-a3b8hyyr	1275	11	and	and	CC
cord-006860-a3b8hyyr	1275	12	Di	Di	NNP
cord-006860-a3b8hyyr	1275	13	~	~	NFP
cord-006860-a3b8hyyr	1275	14	nostica	nostica	NNP
cord-006860-a3b8hyyr	1275	15	Stage	Stage	NNP
cord-006860-a3b8hyyr	1275	16	(	(	-LRB-
cord-006860-a3b8hyyr	1275	17	Vile	Vile	NNP
cord-006860-a3b8hyyr	1275	18	)	)	-RRB-
cord-006860-a3b8hyyr	1275	19	.	.	.
cord-006860-a3b8hyyr	1276	1	The	the	DT
cord-006860-a3b8hyyr	1276	2	results	result	NNS
cord-006860-a3b8hyyr	1276	3	:	:	:
cord-006860-a3b8hyyr	1276	4	There	there	EX
cord-006860-a3b8hyyr	1276	5	is	be	VBZ
cord-006860-a3b8hyyr	1276	6	an	an	DT
cord-006860-a3b8hyyr	1276	7	increase	increase	NN
cord-006860-a3b8hyyr	1276	8	of	of	IN
cord-006860-a3b8hyyr	1276	9	factor	factor	NN
cord-006860-a3b8hyyr	1276	10	XIIa	XIIa	NNS
cord-006860-a3b8hyyr	1276	11	immediately	immediately	RB
cord-006860-a3b8hyyr	1276	12	after	after	IN
cord-006860-a3b8hyyr	1276	13	starting	start	VBG
cord-006860-a3b8hyyr	1276	14	the	the	DT
cord-006860-a3b8hyyr	1276	15	fihrinolysis	fihrinolysis	NNP
cord-006860-a3b8hyyr	1276	16	(	(	-LRB-
cord-006860-a3b8hyyr	1276	17	max	max	NNP
cord-006860-a3b8hyyr	1276	18	.	.	NNP
cord-006860-a3b8hyyr	1276	19	30	30	CD
cord-006860-a3b8hyyr	1276	20	rain	rain	NN
cord-006860-a3b8hyyr	1276	21	after	after	IN
cord-006860-a3b8hyyr	1276	22	starting	start	VBG
cord-006860-a3b8hyyr	1276	23	)	)	-RRB-
cord-006860-a3b8hyyr	1276	24	;	;	:
cord-006860-a3b8hyyr	1276	25	the	the	DT
cord-006860-a3b8hyyr	1276	26	increase	increase	NN
cord-006860-a3b8hyyr	1276	27	5	5	CD
cord-006860-a3b8hyyr	1277	1	/	/	NFP
cord-006860-a3b8hyyr	1278	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	1278	2	independently	independently	RB
cord-006860-a3b8hyyr	1278	3	of	of	IN
cord-006860-a3b8hyyr	1278	4	the	the	DT
cord-006860-a3b8hyyr	1278	5	thrombolytie	thrombolytie	NN
cord-006860-a3b8hyyr	1278	6	agent	agent	NN
cord-006860-a3b8hyyr	1278	7	.	.	.
cord-006860-a3b8hyyr	1279	1	Parallel	parallel	JJ
cord-006860-a3b8hyyr	1279	2	to	to	IN
cord-006860-a3b8hyyr	1279	3	factor	factor	NN
cord-006860-a3b8hyyr	1279	4	XIIa	XIIa	NNS
cord-006860-a3b8hyyr	1279	5	raises	raise	VBZ
cord-006860-a3b8hyyr	1279	6	factor	factor	NN
cord-006860-a3b8hyyr	1279	7	VIIa	VIIa	NNS
cord-006860-a3b8hyyr	1279	8	without	without	IN
cord-006860-a3b8hyyr	1279	9	significant	significant	JJ
cord-006860-a3b8hyyr	1279	10	changes	change	NNS
cord-006860-a3b8hyyr	1279	11	of	of	IN
cord-006860-a3b8hyyr	1279	12	C1	C1	NNP
cord-006860-a3b8hyyr	1279	13	-	-	HYPH
cord-006860-a3b8hyyr	1279	14	1naotor	1naotor	NNP
cord-006860-a3b8hyyr	1279	15	and	and	CC
cord-006860-a3b8hyyr	1279	16	prekalllkrein	prekalllkrein	NN
cord-006860-a3b8hyyr	1279	17	.	.	.
cord-006860-a3b8hyyr	1280	1	That	that	DT
cord-006860-a3b8hyyr	1280	2	means	mean	VBZ
cord-006860-a3b8hyyr	1280	3	:	:	:
cord-006860-a3b8hyyr	1280	4	activation	activation	NN
cord-006860-a3b8hyyr	1280	5	of	of	IN
cord-006860-a3b8hyyr	1280	6	XIIa	XIIa	NNS
cord-006860-a3b8hyyr	1280	7	and	and	CC
cord-006860-a3b8hyyr	1280	8	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1280	9	pathway	pathway	NN
cord-006860-a3b8hyyr	1280	10	leads	lead	VBZ
cord-006860-a3b8hyyr	1280	11	to	to	IN
cord-006860-a3b8hyyr	1280	12	relatively	relatively	RB
cord-006860-a3b8hyyr	1280	13	mild	mild	JJ
cord-006860-a3b8hyyr	1280	14	c.hanges	c.hanges	NFP
cord-006860-a3b8hyyr	1280	15	in	in	IN
cord-006860-a3b8hyyr	1280	16	kallikrein	kallikrein	NNP
cord-006860-a3b8hyyr	1280	17	system	system	NNP
cord-006860-a3b8hyyr	1280	18	,	,	,
cord-006860-a3b8hyyr	1280	19	hut	hut	NNP
cord-006860-a3b8hyyr	1280	20	to	to	IN
cord-006860-a3b8hyyr	1280	21	significant	significant	JJ
cord-006860-a3b8hyyr	1280	22	activation	activation	NN
cord-006860-a3b8hyyr	1280	23	of	of	IN
cord-006860-a3b8hyyr	1280	24	extrinsic	extrinsic	JJ
cord-006860-a3b8hyyr	1280	25	system	system	NN
cord-006860-a3b8hyyr	1280	26	by	by	IN
cord-006860-a3b8hyyr	1280	27	VIla	vila	NN
cord-006860-a3b8hyyr	1280	28	-	-	HYPH
cord-006860-a3b8hyyr	1280	29	tissue	tissue	NN
cord-006860-a3b8hyyr	1280	30	factor	factor	NN
cord-006860-a3b8hyyr	1280	31	.	.	.
cord-006860-a3b8hyyr	1281	1	In	in	IN
cord-006860-a3b8hyyr	1281	2	some	some	DT
cord-006860-a3b8hyyr	1281	3	patients	patient	NNS
cord-006860-a3b8hyyr	1281	4	is	be	VBZ
cord-006860-a3b8hyyr	1281	5	an	an	DT
cord-006860-a3b8hyyr	1281	6	additional	additional	JJ
cord-006860-a3b8hyyr	1281	7	rise	rise	NN
cord-006860-a3b8hyyr	1281	8	in	in	IN
cord-006860-a3b8hyyr	1281	9	the	the	DT
cord-006860-a3b8hyyr	1281	10	system	system	NN
cord-006860-a3b8hyyr	1281	11	XIIa	XIIa	NNS
cord-006860-a3b8hyyr	1281	12	-VIIa	-VIIa	NNP
cord-006860-a3b8hyyr	1281	13	,	,	,
cord-006860-a3b8hyyr	1281	14	when	when	WRB
cord-006860-a3b8hyyr	1281	15	the	the	DT
cord-006860-a3b8hyyr	1281	16	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1281	17	system	system	NN
cord-006860-a3b8hyyr	1281	18	is	be	VBZ
cord-006860-a3b8hyyr	1281	19	already	already	RB
cord-006860-a3b8hyyr	1281	20	in	in	IN
cord-006860-a3b8hyyr	1281	21	the	the	DT
cord-006860-a3b8hyyr	1281	22	normal	normal	JJ
cord-006860-a3b8hyyr	1281	23	range	range	NN
cord-006860-a3b8hyyr	1281	24	.	.	.
cord-006860-a3b8hyyr	1282	1	There	there	EX
cord-006860-a3b8hyyr	1282	2	will	will	MD
cord-006860-a3b8hyyr	1282	3	need	need	VB
cord-006860-a3b8hyyr	1282	4	further	further	JJ
cord-006860-a3b8hyyr	1282	5	investigations	investigation	NNS
cord-006860-a3b8hyyr	1282	6	to	to	TO
cord-006860-a3b8hyyr	1282	7	define	define	VB
cord-006860-a3b8hyyr	1282	8	the	the	DT
cord-006860-a3b8hyyr	1282	9	risk	risk	NN
cord-006860-a3b8hyyr	1282	10	of	of	IN
cord-006860-a3b8hyyr	1282	11	reocclusion	reocclusion	NN
cord-006860-a3b8hyyr	1282	12	as	as	IN
cord-006860-a3b8hyyr	1282	13	a	a	DT
cord-006860-a3b8hyyr	1282	14	result	result	NN
cord-006860-a3b8hyyr	1282	15	of	of	IN
cord-006860-a3b8hyyr	1282	16	activation	activation	NN
cord-006860-a3b8hyyr	1282	17	of	of	IN
cord-006860-a3b8hyyr	1282	18	faktor	faktor	NNP
cord-006860-a3b8hyyr	1282	19	VIIa	VIIa	NNS
cord-006860-a3b8hyyr	1282	20	by	by	IN
cord-006860-a3b8hyyr	1282	21	faktor	faktor	NNP
cord-006860-a3b8hyyr	1282	22	>	>	XX
cord-006860-a3b8hyyr	1283	1	LI	LI	NNP
cord-006860-a3b8hyyr	1283	2	Ia.	Iowa	NNP
cord-006860-a3b8hyyr	1283	3	Autoimmune	Autoimmune	NNP
cord-006860-a3b8hyyr	1283	4	thrombocytopenic	thrombocytopenic	JJ
cord-006860-a3b8hyyr	1283	5	purpura	purpura	NN
cord-006860-a3b8hyyr	1283	6	(	(	-LRB-
cord-006860-a3b8hyyr	1283	7	AITP	AITP	NNP
cord-006860-a3b8hyyr	1283	8	)	)	-RRB-
cord-006860-a3b8hyyr	1283	9	is	be	VBZ
cord-006860-a3b8hyyr	1283	10	a	a	DT
cord-006860-a3b8hyyr	1283	11	frequent	frequent	JJ
cord-006860-a3b8hyyr	1283	12	complication	complication	NN
cord-006860-a3b8hyyr	1283	13	of	of	IN
cord-006860-a3b8hyyr	1283	14	chronic	chronic	JJ
cord-006860-a3b8hyyr	1283	15	lymphocytic	lymphocytic	JJ
cord-006860-a3b8hyyr	1283	16	leukemia	leukemia	NN
cord-006860-a3b8hyyr	1283	17	(	(	-LRB-
cord-006860-a3b8hyyr	1283	18	CLL	CLL	NNP
cord-006860-a3b8hyyr	1283	19	]	]	-RRB-
cord-006860-a3b8hyyr	1283	20	which	which	WDT
cord-006860-a3b8hyyr	1283	21	developes	develop	VBZ
cord-006860-a3b8hyyr	1283	22	on	on	IN
cord-006860-a3b8hyyr	1283	23	different	different	JJ
cord-006860-a3b8hyyr	1283	24	stages	stage	NNS
cord-006860-a3b8hyyr	1283	25	of	of	IN
cord-006860-a3b8hyyr	1283	26	the	the	DT
cord-006860-a3b8hyyr	1283	27	disease	disease	NN
cord-006860-a3b8hyyr	1283	28	and	and	CC
cord-006860-a3b8hyyr	1283	29	needs	need	VBZ
cord-006860-a3b8hyyr	1283	30	special	special	JJ
cord-006860-a3b8hyyr	1283	31	treatment	treatment	NN
cord-006860-a3b8hyyr	1283	32	measure	measure	NN
cord-006860-a3b8hyyr	1283	33	.	.	.
cord-006860-a3b8hyyr	1284	1	Mechanism	mechanism	NN
cord-006860-a3b8hyyr	1284	2	of	of	IN
cord-006860-a3b8hyyr	1284	3	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	1284	4	disorders	disorder	NNS
cord-006860-a3b8hyyr	1284	5	in	in	IN
cord-006860-a3b8hyyr	1284	6	CLL	CLL	NNP
cord-006860-a3b8hyyr	1284	7	remains	remain	VBZ
cord-006860-a3b8hyyr	1284	8	uncleared	uncleared	JJ
cord-006860-a3b8hyyr	1284	9	.	.	.
cord-006860-a3b8hyyr	1285	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1285	2	investigated	investigate	VBD
cord-006860-a3b8hyyr	1285	3	immunologic	immunologic	JJ
cord-006860-a3b8hyyr	1285	4	phenotype	phenotype	NN
cord-006860-a3b8hyyr	1285	5	of	of	IN
cord-006860-a3b8hyyr	1285	6	blood	blood	NN
cord-006860-a3b8hyyr	1285	7	lymphoid	lymphoid	NN
cord-006860-a3b8hyyr	1285	8	cells	cell	NNS
cord-006860-a3b8hyyr	1285	9	in	in	IN
cord-006860-a3b8hyyr	1285	10	22	22	CD
cord-006860-a3b8hyyr	1285	11	patients	patient	NNS
cord-006860-a3b8hyyr	1285	12	suffering	suffer	VBG
cord-006860-a3b8hyyr	1285	13	from	from	IN
cord-006860-a3b8hyyr	1285	14	CLL	CLL	NNP
cord-006860-a3b8hyyr	1285	15	with	with	IN
cord-006860-a3b8hyyr	1285	16	AITP	AITP	NNP
cord-006860-a3b8hyyr	1285	17	.	.	.
cord-006860-a3b8hyyr	1286	1	In	in	IN
cord-006860-a3b8hyyr	1286	2	these	these	DT
cord-006860-a3b8hyyr	1286	3	patients	patient	NNS
cord-006860-a3b8hyyr	1286	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	1286	5	did	do	VBD
cord-006860-a3b8hyyr	1286	6	not	not	RB
cord-006860-a3b8hyyr	1286	7	observe	observe	VB
cord-006860-a3b8hyyr	1286	8	disorders	disorder	NNS
cord-006860-a3b8hyyr	1286	9	in	in	IN
cord-006860-a3b8hyyr	1286	10	expression	expression	NN
cord-006860-a3b8hyyr	1286	11	of	of	IN
cord-006860-a3b8hyyr	1286	12	B	b	NN
cord-006860-a3b8hyyr	1286	13	-	-	HYPH
cord-006860-a3b8hyyr	1286	14	lineage	lineage	NN
cord-006860-a3b8hyyr	1286	15	markers	marker	NNS
cord-006860-a3b8hyyr	1286	16	as	as	IN
cord-006860-a3b8hyyr	1286	17	compared	compare	VBN
cord-006860-a3b8hyyr	1286	18	with	with	IN
cord-006860-a3b8hyyr	1286	19	CLL	CLL	NNP
cord-006860-a3b8hyyr	1286	20	patients	patient	NNS
cord-006860-a3b8hyyr	1286	21	without	without	IN
cord-006860-a3b8hyyr	1286	22	immune	immune	JJ
cord-006860-a3b8hyyr	1286	23	complications	complication	NNS
cord-006860-a3b8hyyr	1286	24	(	(	-LRB-
cord-006860-a3b8hyyr	1286	25	13	13	CD
cord-006860-a3b8hyyr	1286	26	patients	patient	NNS
cord-006860-a3b8hyyr	1286	27	)	)	-RRB-
cord-006860-a3b8hyyr	1286	28	.	.	.
cord-006860-a3b8hyyr	1287	1	But	but	CC
cord-006860-a3b8hyyr	1287	2	in	in	IN
cord-006860-a3b8hyyr	1287	3	the	the	DT
cord-006860-a3b8hyyr	1287	4	1st	1st	JJ
cord-006860-a3b8hyyr	1287	5	group	group	NN
cord-006860-a3b8hyyr	1287	6	of	of	IN
cord-006860-a3b8hyyr	1287	7	the	the	DT
cord-006860-a3b8hyyr	1287	8	patients	patient	NNS
cord-006860-a3b8hyyr	1287	9	the	the	DT
cord-006860-a3b8hyyr	1287	10	greater	great	JJR
cord-006860-a3b8hyyr	1287	11	number	number	NN
cord-006860-a3b8hyyr	1287	12	of	of	IN
cord-006860-a3b8hyyr	1287	13	B	B	NNP
cord-006860-a3b8hyyr	1287	14	-	-	HYPH
cord-006860-a3b8hyyr	1287	15	celts	celts	NNP
cord-006860-a3b8hyyr	1287	16	expressed	express	VBD
cord-006860-a3b8hyyr	1287	17	markers	marker	NNS
cord-006860-a3b8hyyr	1287	18	of	of	IN
cord-006860-a3b8hyyr	1287	19	activation	activation	NN
cord-006860-a3b8hyyr	1287	20	.	.	.
cord-006860-a3b8hyyr	1288	1	According	accord	VBG
cord-006860-a3b8hyyr	1288	2	to	to	IN
cord-006860-a3b8hyyr	1288	3	Ig	Ig	NNP
cord-006860-a3b8hyyr	1288	4	heavy	heavy	JJ
cord-006860-a3b8hyyr	1288	5	chain	chain	NN
cord-006860-a3b8hyyr	1288	6	expression	expression	NN
cord-006860-a3b8hyyr	1288	7	,	,	,
cord-006860-a3b8hyyr	1288	8	the	the	DT
cord-006860-a3b8hyyr	1288	9	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	1288	10	in	in	IN
cord-006860-a3b8hyyr	1288	11	most	most	JJS
cord-006860-a3b8hyyr	1288	12	cases	case	NNS
cord-006860-a3b8hyyr	1288	13	of	of	IN
cord-006860-a3b8hyyr	1288	14	CLL	CLL	NNP
cord-006860-a3b8hyyr	1288	15	complicated	complicate	VBN
cord-006860-a3b8hyyr	1288	16	by	by	IN
cord-006860-a3b8hyyr	1288	17	AITP	AITP	NNP
cord-006860-a3b8hyyr	1288	18	had	have	VBD
cord-006860-a3b8hyyr	1288	19	more	more	RBR
cord-006860-a3b8hyyr	1288	20	mature	mature	JJ
cord-006860-a3b8hyyr	1288	21	phenotype	phenotype	NN
cord-006860-a3b8hyyr	1288	22	.	.	.
cord-006860-a3b8hyyr	1289	1	In	in	IN
cord-006860-a3b8hyyr	1289	2	all	all	DT
cord-006860-a3b8hyyr	1289	3	patients	patient	NNS
cord-006860-a3b8hyyr	1289	4	with	with	IN
cord-006860-a3b8hyyr	1289	5	k	k	NNP
cord-006860-a3b8hyyr	1289	6	phenofype	phenofype	NNP
cord-006860-a3b8hyyr	1289	7	of	of	IN
cord-006860-a3b8hyyr	1289	8	CLL	CLL	NNP
cord-006860-a3b8hyyr	1289	9	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	1289	10	we	-PRON-	PRP
cord-006860-a3b8hyyr	1289	11	found	find	VBD
cord-006860-a3b8hyyr	1289	12	immune	immune	JJ
cord-006860-a3b8hyyr	1289	13	disorders	disorder	NNS
cord-006860-a3b8hyyr	1289	14	.	.	.
cord-006860-a3b8hyyr	1290	1	The	the	DT
cord-006860-a3b8hyyr	1290	2	development	development	NN
cord-006860-a3b8hyyr	1290	3	of	of	IN
cord-006860-a3b8hyyr	1290	4	AITP	AITP	NNP
cord-006860-a3b8hyyr	1290	5	was	be	VBD
cord-006860-a3b8hyyr	1290	6	accompanied	accompany	VBN
cord-006860-a3b8hyyr	1290	7	by	by	IN
cord-006860-a3b8hyyr	1290	8	lowered	lower	VBN
cord-006860-a3b8hyyr	1290	9	level	level	NN
cord-006860-a3b8hyyr	1290	10	of	of	IN
cord-006860-a3b8hyyr	1290	11	T	t	NN
cord-006860-a3b8hyyr	1290	12	cells	cell	NNS
cord-006860-a3b8hyyr	1290	13	and	and	CC
cord-006860-a3b8hyyr	1290	14	changed	change	VBD
cord-006860-a3b8hyyr	1290	15	dis'flibution	dis'flibution	NN
cord-006860-a3b8hyyr	1290	16	of	of	IN
cord-006860-a3b8hyyr	1290	17	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1290	18	immunoreguiatory	immunoreguiatory	JJ
cord-006860-a3b8hyyr	1290	19	subsets	subset	NNS
cord-006860-a3b8hyyr	1290	20	:	:	:
cord-006860-a3b8hyyr	1290	21	diminished	diminished	JJ
cord-006860-a3b8hyyr	1290	22	number	number	NN
cord-006860-a3b8hyyr	1290	23	of	of	IN
cord-006860-a3b8hyyr	1290	24	CDZ	cdz	NN
cord-006860-a3b8hyyr	1290	25	~	~	NFP
cord-006860-a3b8hyyr	1290	26	cells	cell	NNS
cord-006860-a3b8hyyr	1290	27	and	and	CC
cord-006860-a3b8hyyr	1290	28	increased	increase	VBD
cord-006860-a3b8hyyr	1290	29	one	one	CD
cord-006860-a3b8hyyr	1290	30	of	of	IN
cord-006860-a3b8hyyr	1290	31	CD~'÷lymphocytes	CD~'÷lymphocytes	NNP
cord-006860-a3b8hyyr	1290	32	.	.	.
cord-006860-a3b8hyyr	1291	1	The	the	DT
cord-006860-a3b8hyyr	1291	2	results	result	NNS
cord-006860-a3b8hyyr	1291	3	of	of	IN
cord-006860-a3b8hyyr	1291	4	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1291	5	investigations	investigation	NNS
cord-006860-a3b8hyyr	1291	6	undirectly	undirectly	RB
cord-006860-a3b8hyyr	1291	7	proved	prove	VBD
cord-006860-a3b8hyyr	1291	8	that	that	IN
cord-006860-a3b8hyyr	1291	9	malignant	malignant	JJ
cord-006860-a3b8hyyr	1291	10	B	b	NN
cord-006860-a3b8hyyr	1291	11	-	-	HYPH
cord-006860-a3b8hyyr	1291	12	cells	cell	NNS
cord-006860-a3b8hyyr	1291	13	in	in	IN
cord-006860-a3b8hyyr	1291	14	CLL	CLL	NNP
cord-006860-a3b8hyyr	1291	15	are	be	VBP
cord-006860-a3b8hyyr	1291	16	involved	involve	VBN
cord-006860-a3b8hyyr	1291	17	in	in	IN
cord-006860-a3b8hyyr	1291	18	production	production	NN
cord-006860-a3b8hyyr	1291	19	of	of	IN
cord-006860-a3b8hyyr	1291	20	autoantibodies	autoantibody	NNS
cord-006860-a3b8hyyr	1291	21	against	against	IN
cord-006860-a3b8hyyr	1291	22	blood	blood	NN
cord-006860-a3b8hyyr	1291	23	cells	cell	NNS
cord-006860-a3b8hyyr	1291	24	.	.	.
cord-006860-a3b8hyyr	1292	1	Dysbalance	Dysbalance	NNP
cord-006860-a3b8hyyr	1292	2	in	in	IN
cord-006860-a3b8hyyr	1292	3	T	t	NN
cord-006860-a3b8hyyr	1292	4	-	-	HYPH
cord-006860-a3b8hyyr	1292	5	cell	cell	NN
cord-006860-a3b8hyyr	1292	6	system	system	NN
cord-006860-a3b8hyyr	1292	7	with	with	IN
cord-006860-a3b8hyyr	1292	8	functional	functional	JJ
cord-006860-a3b8hyyr	1292	9	disturbances	disturbance	NNS
cord-006860-a3b8hyyr	1292	10	of	of	IN
cord-006860-a3b8hyyr	1292	11	immunoregulation	immunoregulation	NN
cord-006860-a3b8hyyr	1292	12	are	be	VBP
cord-006860-a3b8hyyr	1292	13	significant	significant	JJ
cord-006860-a3b8hyyr	1292	14	in	in	IN
cord-006860-a3b8hyyr	1292	15	development	development	NN
cord-006860-a3b8hyyr	1292	16	of	of	IN
cord-006860-a3b8hyyr	1292	17	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	1292	18	complications	complication	NNS
cord-006860-a3b8hyyr	1292	19	in	in	IN
cord-006860-a3b8hyyr	1292	20	CLL	CLL	NNP
cord-006860-a3b8hyyr	1292	21	A24	A24	NNP
cord-006860-a3b8hyyr	1293	1	In	in	IN
cord-006860-a3b8hyyr	1293	2	women	woman	NNS
cord-006860-a3b8hyyr	1293	3	with	with	IN
cord-006860-a3b8hyyr	1293	4	severe	severe	JJ
cord-006860-a3b8hyyr	1293	5	FVII	FVII	NNP
cord-006860-a3b8hyyr	1293	6	deficency	deficency	NN
cord-006860-a3b8hyyr	1293	7	(	(	-LRB-
cord-006860-a3b8hyyr	1293	8	<	<	NNP
cord-006860-a3b8hyyr	1293	9	10	10	CD
cord-006860-a3b8hyyr	1293	10	%	%	NN
cord-006860-a3b8hyyr	1293	11	)	)	-RRB-
cord-006860-a3b8hyyr	1294	1	hypermenorrhagia	hypermenorrhagia	NNP
cord-006860-a3b8hyyr	1294	2	may	may	MD
cord-006860-a3b8hyyr	1294	3	cause	cause	VB
cord-006860-a3b8hyyr	1294	4	life	life	NN
cord-006860-a3b8hyyr	1294	5	threatening	threaten	VBG
cord-006860-a3b8hyyr	1294	6	blood	blood	NN
cord-006860-a3b8hyyr	1294	7	loss	loss	NN
cord-006860-a3b8hyyr	1294	8	.	.	.
cord-006860-a3b8hyyr	1295	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	1295	2	,	,	,
cord-006860-a3b8hyyr	1295	3	hysterectomy	hysterectomy	NN
cord-006860-a3b8hyyr	1295	4	at	at	IN
cord-006860-a3b8hyyr	1295	5	a	a	DT
cord-006860-a3b8hyyr	1295	6	young	young	JJ
cord-006860-a3b8hyyr	1295	7	age	age	NN
cord-006860-a3b8hyyr	1295	8	is	be	VBZ
cord-006860-a3b8hyyr	1295	9	reported	report	VBN
cord-006860-a3b8hyyr	1295	10	frequently	frequently	RB
cord-006860-a3b8hyyr	1295	11	in	in	IN
cord-006860-a3b8hyyr	1295	12	the	the	DT
cord-006860-a3b8hyyr	1295	13	literature	literature	NN
cord-006860-a3b8hyyr	1295	14	.	.	.
cord-006860-a3b8hyyr	1296	1	A	a	DT
cord-006860-a3b8hyyr	1296	2	12	12	CD
cord-006860-a3b8hyyr	1296	3	year	year	NN
cord-006860-a3b8hyyr	1296	4	old	old	JJ
cord-006860-a3b8hyyr	1296	5	girl	girl	NN
cord-006860-a3b8hyyr	1296	6	without	without	IN
cord-006860-a3b8hyyr	1296	7	history	history	NN
cord-006860-a3b8hyyr	1296	8	for	for	IN
cord-006860-a3b8hyyr	1296	9	a	a	DT
cord-006860-a3b8hyyr	1296	10	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1296	11	disorder	disorder	NN
cord-006860-a3b8hyyr	1296	12	was	be	VBD
cord-006860-a3b8hyyr	1296	13	transfered	transfer	VBN
cord-006860-a3b8hyyr	1296	14	with	with	IN
cord-006860-a3b8hyyr	1296	15	hypermenorrhagia	hypermenorrhagia	NNP
cord-006860-a3b8hyyr	1296	16	.	.	.
cord-006860-a3b8hyyr	1297	1	The	the	DT
cord-006860-a3b8hyyr	1297	2	initial	initial	JJ
cord-006860-a3b8hyyr	1297	3	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1297	4	data	datum	NNS
cord-006860-a3b8hyyr	1297	5	revealed	reveal	VBD
cord-006860-a3b8hyyr	1297	6	an	an	DT
cord-006860-a3b8hyyr	1297	7	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	1297	8	Quick	quick	JJ
cord-006860-a3b8hyyr	1297	9	-	-	HYPH
cord-006860-a3b8hyyr	1297	10	test	test	NN
cord-006860-a3b8hyyr	1297	11	of	of	IN
cord-006860-a3b8hyyr	1297	12	30	30	CD
cord-006860-a3b8hyyr	1297	13	%	%	NN
cord-006860-a3b8hyyr	1297	14	due	due	JJ
cord-006860-a3b8hyyr	1297	15	to	to	IN
cord-006860-a3b8hyyr	1297	16	FVll	fvll	CD
cord-006860-a3b8hyyr	1297	17	of	of	IN
cord-006860-a3b8hyyr	1297	18	9,0	9,0	CD
cord-006860-a3b8hyyr	1297	19	%	%	NN
cord-006860-a3b8hyyr	1297	20	,	,	,
cord-006860-a3b8hyyr	1297	21	normal	normal	JJ
cord-006860-a3b8hyyr	1297	22	platelet	platelet	NN
cord-006860-a3b8hyyr	1297	23	count	count	NN
cord-006860-a3b8hyyr	1297	24	and	and	CC
cord-006860-a3b8hyyr	1297	25	hemoglobin	hemoglobin	NN
cord-006860-a3b8hyyr	1297	26	level	level	NN
cord-006860-a3b8hyyr	1297	27	of	of	IN
cord-006860-a3b8hyyr	1297	28	7,2	7,2	CD
cord-006860-a3b8hyyr	1297	29	g	g	NN
cord-006860-a3b8hyyr	1297	30	/	/	SYM
cord-006860-a3b8hyyr	1297	31	dl	dl	NN
cord-006860-a3b8hyyr	1297	32	.	.	.
cord-006860-a3b8hyyr	1298	1	Antifibrinolytic	antifibrinolytic	JJ
cord-006860-a3b8hyyr	1298	2	therapy	therapy	NN
cord-006860-a3b8hyyr	1298	3	(	(	-LRB-
cord-006860-a3b8hyyr	1298	4	tranexamic	tranexamic	JJ
cord-006860-a3b8hyyr	1298	5	acid	acid	NN
cord-006860-a3b8hyyr	1298	6	4x15mg	4x15mg	CD
cord-006860-a3b8hyyr	1298	7	/	/	SYM
cord-006860-a3b8hyyr	1298	8	kg	kg	NNP
cord-006860-a3b8hyyr	1298	9	BW	BW	NNP
cord-006860-a3b8hyyr	1298	10	/	/	SYM
cord-006860-a3b8hyyr	1298	11	d	d	NN
cord-006860-a3b8hyyr	1298	12	)	)	-RRB-
cord-006860-a3b8hyyr	1298	13	and	and	CC
cord-006860-a3b8hyyr	1298	14	lynestrenol	lynestrenol	NNP
cord-006860-a3b8hyyr	1298	15	substitution	substitution	NN
cord-006860-a3b8hyyr	1298	16	were	be	VBD
cord-006860-a3b8hyyr	1298	17	started	start	VBN
cord-006860-a3b8hyyr	1298	18	to	to	TO
cord-006860-a3b8hyyr	1298	19	reduce	reduce	VB
cord-006860-a3b8hyyr	1298	20	the	the	DT
cord-006860-a3b8hyyr	1298	21	hemorrrhage	hemorrrhage	NN
cord-006860-a3b8hyyr	1298	22	.	.	.
cord-006860-a3b8hyyr	1299	1	Despite	despite	IN
cord-006860-a3b8hyyr	1299	2	treatment	treatment	NN
cord-006860-a3b8hyyr	1299	3	the	the	DT
cord-006860-a3b8hyyr	1299	4	daily	daily	JJ
cord-006860-a3b8hyyr	1299	5	blood	blood	NN
cord-006860-a3b8hyyr	1299	6	loss	loss	NN
cord-006860-a3b8hyyr	1299	7	increased	increase	VBD
cord-006860-a3b8hyyr	1299	8	to	to	IN
cord-006860-a3b8hyyr	1299	9	a	a	DT
cord-006860-a3b8hyyr	1299	10	maximum	maximum	NN
cord-006860-a3b8hyyr	1299	11	of	of	IN
cord-006860-a3b8hyyr	1299	12	290ml	290ml	NN
cord-006860-a3b8hyyr	1299	13	.	.	.
cord-006860-a3b8hyyr	1300	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	1300	2	,	,	,
cord-006860-a3b8hyyr	1300	3	substitution	substitution	NN
cord-006860-a3b8hyyr	1300	4	therapy	therapy	NN
cord-006860-a3b8hyyr	1300	5	with	with	IN
cord-006860-a3b8hyyr	1300	6	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	1301	1	FVIla	FVIla	NNP
cord-006860-a3b8hyyr	1301	2	(	(	-LRB-
cord-006860-a3b8hyyr	1301	3	rFVIla	rfvila	CD
cord-006860-a3b8hyyr	1301	4	)	)	-RRB-
cord-006860-a3b8hyyr	1301	5	(	(	-LRB-
cord-006860-a3b8hyyr	1301	6	NovoNordisk	NovoNordisk	NNP
cord-006860-a3b8hyyr	1301	7	)	)	-RRB-
cord-006860-a3b8hyyr	1301	8	was	be	VBD
cord-006860-a3b8hyyr	1301	9	started	start	VBN
cord-006860-a3b8hyyr	1301	10	at	at	IN
cord-006860-a3b8hyyr	1301	11	a	a	DT
cord-006860-a3b8hyyr	1301	12	dose	dose	NN
cord-006860-a3b8hyyr	1301	13	of	of	IN
cord-006860-a3b8hyyr	1301	14	15	15	CD
cord-006860-a3b8hyyr	1301	15	Ilg	Ilg	NNP
cord-006860-a3b8hyyr	1301	16	/	/	SYM
cord-006860-a3b8hyyr	1301	17	kg	kg	NNP
cord-006860-a3b8hyyr	1301	18	BW	BW	NNP
cord-006860-a3b8hyyr	1301	19	q	q	NNP
cord-006860-a3b8hyyr	1301	20	6	6	CD
cord-006860-a3b8hyyr	1301	21	h.	h.	NN
cord-006860-a3b8hyyr	1302	1	Subsequently	subsequently	RB
cord-006860-a3b8hyyr	1302	2	blood	blood	NN
cord-006860-a3b8hyyr	1302	3	loss	loss	NN
cord-006860-a3b8hyyr	1302	4	decreased	decrease	VBD
cord-006860-a3b8hyyr	1302	5	to	to	IN
cord-006860-a3b8hyyr	1302	6	30ml	30ml	NN
cord-006860-a3b8hyyr	1302	7	/	/	SYM
cord-006860-a3b8hyyr	1302	8	d	d	XX
cord-006860-a3b8hyyr	1302	9	,	,	,
cord-006860-a3b8hyyr	1302	10	but	but	CC
cord-006860-a3b8hyyr	1302	11	even	even	RB
cord-006860-a3b8hyyr	1302	12	with	with	IN
cord-006860-a3b8hyyr	1302	13	an	an	DT
cord-006860-a3b8hyyr	1302	14	increasing	increase	VBG
cord-006860-a3b8hyyr	1302	15	dose	dose	NN
cord-006860-a3b8hyyr	1302	16	of	of	IN
cord-006860-a3b8hyyr	1302	17	rFVlla	rfvlla	CD
cord-006860-a3b8hyyr	1303	1	up	up	IN
cord-006860-a3b8hyyr	1303	2	to	to	TO
cord-006860-a3b8hyyr	1303	3	35	35	CD
cord-006860-a3b8hyyr	1303	4	I	-PRON-	PRP
cord-006860-a3b8hyyr	1304	1	~g	~g	NNP
cord-006860-a3b8hyyr	1304	2	/	/	SYM
cord-006860-a3b8hyyr	1304	3	kg	kg	NNP
cord-006860-a3b8hyyr	1304	4	BWq	BWq	NNS
cord-006860-a3b8hyyr	1304	5	4h	4h	CD
cord-006860-a3b8hyyr	1304	6	(	(	-LRB-
cord-006860-a3b8hyyr	1304	7	FVil	fvil	CD
cord-006860-a3b8hyyr	1304	8	activity	activity	NN
cord-006860-a3b8hyyr	1304	9	max	max	NN
cord-006860-a3b8hyyr	1304	10	.	.	.
cord-006860-a3b8hyyr	1305	1	7400	7400	CD
cord-006860-a3b8hyyr	1305	2	%	%	NN
cord-006860-a3b8hyyr	1305	3	10	10	CD
cord-006860-a3b8hyyr	1305	4	min	min	NN
cord-006860-a3b8hyyr	1305	5	after	after	IN
cord-006860-a3b8hyyr	1305	6	injection	injection	NN
cord-006860-a3b8hyyr	1305	7	)	)	-RRB-
cord-006860-a3b8hyyr	1305	8	and	and	CC
cord-006860-a3b8hyyr	1305	9	additional	additional	JJ
cord-006860-a3b8hyyr	1305	10	hormonal	hormonal	JJ
cord-006860-a3b8hyyr	1305	11	support	support	NN
cord-006860-a3b8hyyr	1305	12	with	with	IN
cord-006860-a3b8hyyr	1305	13	a	a	DT
cord-006860-a3b8hyyr	1305	14	LH	LH	NNP
cord-006860-a3b8hyyr	1305	15	-	-	HYPH
cord-006860-a3b8hyyr	1305	16	FSH	fsh	NN
cord-006860-a3b8hyyr	1305	17	-	-	HYPH
cord-006860-a3b8hyyr	1305	18	anatgonist	anatgonist	NN
cord-006860-a3b8hyyr	1306	1	some	some	DT
cord-006860-a3b8hyyr	1306	2	hemorrhage	hemorrhage	NN
cord-006860-a3b8hyyr	1306	3	remained	remain	VBD
cord-006860-a3b8hyyr	1306	4	.	.	.
cord-006860-a3b8hyyr	1307	1	A	a	DT
cord-006860-a3b8hyyr	1307	2	short	short	JJ
cord-006860-a3b8hyyr	1307	3	.course	.course	.
cord-006860-a3b8hyyr	1307	4	of	of	IN
cord-006860-a3b8hyyr	1307	5	methergin	methergin	NNP
cord-006860-a3b8hyyr	1307	6	was	be	VBD
cord-006860-a3b8hyyr	1307	7	stopped	stop	VBN
cord-006860-a3b8hyyr	1307	8	due	due	JJ
cord-006860-a3b8hyyr	1307	9	to	to	IN
cord-006860-a3b8hyyr	1307	10	severe	severe	JJ
cord-006860-a3b8hyyr	1307	11	pain	pain	NN
cord-006860-a3b8hyyr	1307	12	.	.	.
cord-006860-a3b8hyyr	1308	1	Ultrasound	ultrasound	NN
cord-006860-a3b8hyyr	1308	2	of	of	IN
cord-006860-a3b8hyyr	1308	3	the	the	DT
cord-006860-a3b8hyyr	1308	4	uterus	uterus	NN
cord-006860-a3b8hyyr	1308	5	revealed	reveal	VBD
cord-006860-a3b8hyyr	1308	6	a	a	DT
cord-006860-a3b8hyyr	1308	7	hypertrophic	hypertrophic	JJ
cord-006860-a3b8hyyr	1308	8	endometrium	endometrium	NN
cord-006860-a3b8hyyr	1308	9	causing	cause	VBG
cord-006860-a3b8hyyr	1308	10	the	the	DT
cord-006860-a3b8hyyr	1308	11	persistent	persistent	JJ
cord-006860-a3b8hyyr	1308	12	bleeding	bleeding	NN
cord-006860-a3b8hyyr	1308	13	.	.	.
cord-006860-a3b8hyyr	1309	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1309	2	decreased	decrease	VBD
cord-006860-a3b8hyyr	1309	3	slowly	slowly	RB
cord-006860-a3b8hyyr	1309	4	over	over	IN
cord-006860-a3b8hyyr	1309	5	several	several	JJ
cord-006860-a3b8hyyr	1309	6	weeks	week	NNS
cord-006860-a3b8hyyr	1309	7	and	and	CC
cord-006860-a3b8hyyr	1309	8	hemorrhage	hemorrhage	NN
cord-006860-a3b8hyyr	1309	9	stopped	stop	VBD
cord-006860-a3b8hyyr	1309	10	completely	completely	RB
cord-006860-a3b8hyyr	1309	11	after	after	IN
cord-006860-a3b8hyyr	1309	12	40	40	CD
cord-006860-a3b8hyyr	1309	13	d.	d.	NNP
cord-006860-a3b8hyyr	1310	1	The	the	DT
cord-006860-a3b8hyyr	1310	2	total	total	JJ
cord-006860-a3b8hyyr	1310	3	rFVlla	rfvlla	CD
cord-006860-a3b8hyyr	1310	4	dose	dose	NN
cord-006860-a3b8hyyr	1310	5	administered	administer	VBN
cord-006860-a3b8hyyr	1310	6	was	be	VBD
cord-006860-a3b8hyyr	1310	7	118	118	CD
cord-006860-a3b8hyyr	1310	8	rag	rag	NN
cord-006860-a3b8hyyr	1310	9	.	.	.
cord-006860-a3b8hyyr	1311	1	No	no	DT
cord-006860-a3b8hyyr	1311	2	side	side	NN
cord-006860-a3b8hyyr	1311	3	effects	effect	NNS
cord-006860-a3b8hyyr	1311	4	were	be	VBD
cord-006860-a3b8hyyr	1311	5	observed	observe	VBN
cord-006860-a3b8hyyr	1311	6	.	.	.
cord-006860-a3b8hyyr	1312	1	No	no	DT
cord-006860-a3b8hyyr	1312	2	transfusions	transfusion	NNS
cord-006860-a3b8hyyr	1312	3	of	of	IN
cord-006860-a3b8hyyr	1312	4	blood	blood	NN
cord-006860-a3b8hyyr	1312	5	products	product	NNS
cord-006860-a3b8hyyr	1312	6	were	be	VBD
cord-006860-a3b8hyyr	1312	7	necessary	necessary	JJ
cord-006860-a3b8hyyr	1312	8	.	.	.
cord-006860-a3b8hyyr	1313	1	Currently	currently	RB
cord-006860-a3b8hyyr	1313	2	,	,	,
cord-006860-a3b8hyyr	1313	3	menstrual	menstrual	JJ
cord-006860-a3b8hyyr	1313	4	cycle	cycle	NN
cord-006860-a3b8hyyr	1313	5	is	be	VBZ
cord-006860-a3b8hyyr	1313	6	suppressed	suppress	VBN
cord-006860-a3b8hyyr	1313	7	by	by	IN
cord-006860-a3b8hyyr	1313	8	estriosuccinate	estriosuccinate	NNP
cord-006860-a3b8hyyr	1313	9	.	.	.
cord-006860-a3b8hyyr	1314	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	1314	2	:	:	:
cord-006860-a3b8hyyr	1314	3	Due	due	IN
cord-006860-a3b8hyyr	1314	4	to	to	TO
cord-006860-a3b8hyyr	1314	5	close	close	VB
cord-006860-a3b8hyyr	1314	6	cooperation	cooperation	NN
cord-006860-a3b8hyyr	1314	7	with	with	IN
cord-006860-a3b8hyyr	1314	8	a	a	DT
cord-006860-a3b8hyyr	1314	9	specialised	specialised	JJ
cord-006860-a3b8hyyr	1314	10	gynecologist	gynecologist	NN
cord-006860-a3b8hyyr	1314	11	,	,	,
cord-006860-a3b8hyyr	1314	12	hypermenorrhagia	hypermenorrhagia	NNP
cord-006860-a3b8hyyr	1314	13	was	be	VBD
cord-006860-a3b8hyyr	1314	14	controlled	control	VBN
cord-006860-a3b8hyyr	1314	15	and	and	CC
cord-006860-a3b8hyyr	1314	16	in	in	IN
cord-006860-a3b8hyyr	1314	17	this	this	DT
cord-006860-a3b8hyyr	1314	18	woman	woman	NN
cord-006860-a3b8hyyr	1314	19	with	with	IN
cord-006860-a3b8hyyr	1314	20	severe	severe	JJ
cord-006860-a3b8hyyr	1314	21	FVll	fvll	JJ
cord-006860-a3b8hyyr	1314	22	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1315	1	hysterectomy	hysterectomy	NN
cord-006860-a3b8hyyr	1315	2	was	be	VBD
cord-006860-a3b8hyyr	1315	3	avoided	avoid	VBN
cord-006860-a3b8hyyr	1315	4	.	.	.
cord-006860-a3b8hyyr	1316	1	In	in	IN
cord-006860-a3b8hyyr	1316	2	three	three	CD
cord-006860-a3b8hyyr	1316	3	male	male	JJ
cord-006860-a3b8hyyr	1316	4	members	member	NNS
cord-006860-a3b8hyyr	1316	5	aged	age	VBN
cord-006860-a3b8hyyr	1316	6	between	between	IN
cord-006860-a3b8hyyr	1316	7	27	27	CD
cord-006860-a3b8hyyr	1316	8	and	and	CC
cord-006860-a3b8hyyr	1316	9	52	52	CD
cord-006860-a3b8hyyr	1316	10	years	year	NNS
cord-006860-a3b8hyyr	1316	11	of	of	IN
cord-006860-a3b8hyyr	1316	12	a	a	DT
cord-006860-a3b8hyyr	1316	13	family	family	NN
cord-006860-a3b8hyyr	1316	14	suffering	suffer	VBG
cord-006860-a3b8hyyr	1316	15	from	from	IN
cord-006860-a3b8hyyr	1316	16	inherited	inherit	VBN
cord-006860-a3b8hyyr	1316	17	bleeding	bleeding	NN
cord-006860-a3b8hyyr	1316	18	disorders	disorder	NNS
cord-006860-a3b8hyyr	1316	19	the	the	DT
cord-006860-a3b8hyyr	1316	20	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	1316	21	of	of	IN
cord-006860-a3b8hyyr	1316	22	protein	protein	NN
cord-006860-a3b8hyyr	1316	23	Z	Z	NNP
cord-006860-a3b8hyyr	1316	24	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1316	25	was	be	VBD
cord-006860-a3b8hyyr	1316	26	established	establish	VBN
cord-006860-a3b8hyyr	1316	27	.	.	.
cord-006860-a3b8hyyr	1317	1	Plasma	plasma	NN
cord-006860-a3b8hyyr	1317	2	protein	protein	NN
cord-006860-a3b8hyyr	1317	3	Z	z	NN
cord-006860-a3b8hyyr	1317	4	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	1317	5	by	by	IN
cord-006860-a3b8hyyr	1317	6	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	1318	1	(	(	-LRB-
cord-006860-a3b8hyyr	1318	2	Asserachrom	Asserachrom	NNP
cord-006860-a3b8hyyr	1318	3	Protein	Protein	NNP
cord-006860-a3b8hyyr	1318	4	Z	Z	NNP
cord-006860-a3b8hyyr	1318	5	,	,	,
cord-006860-a3b8hyyr	1318	6	Diagnostica	Diagnostica	NNP
cord-006860-a3b8hyyr	1318	7	Stago	Stago	NNP
cord-006860-a3b8hyyr	1318	8	,	,	,
cord-006860-a3b8hyyr	1318	9	France	France	NNP
cord-006860-a3b8hyyr	1318	10	)	)	-RRB-
cord-006860-a3b8hyyr	1318	11	ranged	range	VBD
cord-006860-a3b8hyyr	1318	12	between	between	IN
cord-006860-a3b8hyyr	1318	13	200	200	CD
cord-006860-a3b8hyyr	1318	14	and	and	CC
cord-006860-a3b8hyyr	1318	15	300	300	CD
cord-006860-a3b8hyyr	1318	16	ng	ng	NN
cord-006860-a3b8hyyr	1318	17	/	/	SYM
cord-006860-a3b8hyyr	1318	18	ml	ml	NN
cord-006860-a3b8hyyr	1318	19	.	.	.
cord-006860-a3b8hyyr	1319	1	The	the	DT
cord-006860-a3b8hyyr	1319	2	patients	patient	NNS
cord-006860-a3b8hyyr	1319	3	mostly	mostly	RB
cord-006860-a3b8hyyr	1319	4	suffered	suffer	VBD
cord-006860-a3b8hyyr	1319	5	from	from	IN
cord-006860-a3b8hyyr	1319	6	moderate	moderate	JJ
cord-006860-a3b8hyyr	1319	7	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	1319	8	complications	complication	NNS
cord-006860-a3b8hyyr	1319	9	like	like	IN
cord-006860-a3b8hyyr	1319	10	prolonged	prolong	VBN
cord-006860-a3b8hyyr	1319	11	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1319	12	secondary	secondary	JJ
cord-006860-a3b8hyyr	1319	13	to	to	IN
cord-006860-a3b8hyyr	1319	14	trauma	trauma	NN
cord-006860-a3b8hyyr	1319	15	or	or	CC
cord-006860-a3b8hyyr	1319	16	invasive	invasive	JJ
cord-006860-a3b8hyyr	1319	17	measures	measure	NNS
cord-006860-a3b8hyyr	1319	18	and	and	CC
cord-006860-a3b8hyyr	1319	19	also	also	RB
cord-006860-a3b8hyyr	1319	20	spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	1319	21	hematuria	hematuria	NN
cord-006860-a3b8hyyr	1319	22	.	.	.
cord-006860-a3b8hyyr	1320	1	Previous	previous	JJ
cord-006860-a3b8hyyr	1320	2	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1320	3	investigations	investigation	NNS
cord-006860-a3b8hyyr	1320	4	revealed	reveal	VBD
cord-006860-a3b8hyyr	1320	5	variable	variable	JJ
cord-006860-a3b8hyyr	1320	6	platelet	platelet	NN
cord-006860-a3b8hyyr	1320	7	function	function	NN
cord-006860-a3b8hyyr	1320	8	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	1320	9	and	and	CC
cord-006860-a3b8hyyr	1320	10	transitory	transitory	JJ
cord-006860-a3b8hyyr	1320	11	boderline	boderline	JJ
cord-006860-a3b8hyyr	1320	12	decrease	decrease	NN
cord-006860-a3b8hyyr	1320	13	of	of	IN
cord-006860-a3b8hyyr	1320	14	von	von	NNP
cord-006860-a3b8hyyr	1320	15	-	-	HYPH
cord-006860-a3b8hyyr	1320	16	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	1320	17	factor	factor	NN
cord-006860-a3b8hyyr	1320	18	.	.	.
cord-006860-a3b8hyyr	1321	1	Spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	1321	2	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	1321	3	were	be	VBD
cord-006860-a3b8hyyr	1321	4	rarely	rarely	RB
cord-006860-a3b8hyyr	1321	5	recognized	recognize	VBN
cord-006860-a3b8hyyr	1321	6	,	,	,
cord-006860-a3b8hyyr	1321	7	however	however	RB
cord-006860-a3b8hyyr	1321	8	,	,	,
cord-006860-a3b8hyyr	1321	9	they	-PRON-	PRP
cord-006860-a3b8hyyr	1321	10	occured	occur	VBD
cord-006860-a3b8hyyr	1321	11	more	more	RBR
cord-006860-a3b8hyyr	1321	12	frequently	frequently	RB
cord-006860-a3b8hyyr	1321	13	when	when	WRB
cord-006860-a3b8hyyr	1321	14	analgetics	analgetic	NNS
cord-006860-a3b8hyyr	1321	15	were	be	VBD
cord-006860-a3b8hyyr	1321	16	taken	take	VBN
cord-006860-a3b8hyyr	1321	17	.	.	.
cord-006860-a3b8hyyr	1322	1	Bleeding	bleed	VBG
cord-006860-a3b8hyyr	1322	2	complications	complication	NNS
cord-006860-a3b8hyyr	1322	3	showed	show	VBD
cord-006860-a3b8hyyr	1322	4	good	good	JJ
cord-006860-a3b8hyyr	1322	5	response	response	NN
cord-006860-a3b8hyyr	1322	6	to	to	IN
cord-006860-a3b8hyyr	1322	7	hemostyptic	hemostyptic	JJ
cord-006860-a3b8hyyr	1322	8	measures	measure	NNS
cord-006860-a3b8hyyr	1322	9	and	and	CC
cord-006860-a3b8hyyr	1322	10	antifibrinolytic	antifibrinolytic	JJ
cord-006860-a3b8hyyr	1322	11	therapy	therapy	NN
cord-006860-a3b8hyyr	1322	12	.	.	.
cord-006860-a3b8hyyr	1323	1	The	the	DT
cord-006860-a3b8hyyr	1323	2	use	use	NN
cord-006860-a3b8hyyr	1323	3	of	of	IN
cord-006860-a3b8hyyr	1323	4	PCC	PCC	NNP
cord-006860-a3b8hyyr	1323	5	containing	contain	VBG
cord-006860-a3b8hyyr	1323	6	a	a	DT
cord-006860-a3b8hyyr	1323	7	high	high	JJ
cord-006860-a3b8hyyr	1323	8	level	level	NN
cord-006860-a3b8hyyr	1323	9	of	of	IN
cord-006860-a3b8hyyr	1323	10	protein	protein	NN
cord-006860-a3b8hyyr	1323	11	Z	z	NN
cord-006860-a3b8hyyr	1323	12	in	in	IN
cord-006860-a3b8hyyr	1323	13	these	these	DT
cord-006860-a3b8hyyr	1323	14	patients	patient	NNS
cord-006860-a3b8hyyr	1323	15	is	be	VBZ
cord-006860-a3b8hyyr	1323	16	restrained	restrain	VBN
cord-006860-a3b8hyyr	1323	17	to	to	IN
cord-006860-a3b8hyyr	1323	18	severe	severe	JJ
cord-006860-a3b8hyyr	1323	19	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	1323	20	disorders	disorder	NNS
cord-006860-a3b8hyyr	1323	21	or	or	CC
cord-006860-a3b8hyyr	1323	22	major	major	JJ
cord-006860-a3b8hyyr	1323	23	surgery	surgery	NN
cord-006860-a3b8hyyr	1323	24	.	.	.
cord-006860-a3b8hyyr	1324	1	Defibrotide	Defibrotide	NNP
cord-006860-a3b8hyyr	1324	2	is	be	VBZ
cord-006860-a3b8hyyr	1324	3	a	a	DT
cord-006860-a3b8hyyr	1324	4	mammalian	mammalian	JJ
cord-006860-a3b8hyyr	1324	5	polydeoxyribonucleotide	polydeoxyribonucleotide	NN
cord-006860-a3b8hyyr	1324	6	derived	derive	VBN
cord-006860-a3b8hyyr	1324	7	anti	anti	JJ
cord-006860-a3b8hyyr	1324	8	-	-	JJ
cord-006860-a3b8hyyr	1324	9	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	1324	10	and	and	CC
cord-006860-a3b8hyyr	1324	11	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	1324	12	drug	drug	NN
cord-006860-a3b8hyyr	1324	13	(	(	-LRB-
cord-006860-a3b8hyyr	1324	14	Crinos	Crinos	NNP
cord-006860-a3b8hyyr	1324	15	S.p	S.p	NNP
cord-006860-a3b8hyyr	1324	16	.	.	.
cord-006860-a3b8hyyr	1324	17	A.	A.	NNP
cord-006860-a3b8hyyr	1324	18	,	,	,
cord-006860-a3b8hyyr	1324	19	V"flla	V"flla	NNP
cord-006860-a3b8hyyr	1324	20	Guardia	Guardia	NNP
cord-006860-a3b8hyyr	1324	21	,	,	,
cord-006860-a3b8hyyr	1324	22	Italy	Italy	NNP
cord-006860-a3b8hyyr	1324	23	)	)	-RRB-
cord-006860-a3b8hyyr	1324	24	.	.	.
cord-006860-a3b8hyyr	1325	1	While	while	IN
cord-006860-a3b8hyyr	1325	2	the	the	DT
cord-006860-a3b8hyyr	1325	3	drug	drug	NN
cord-006860-a3b8hyyr	1325	4	is	be	VBZ
cord-006860-a3b8hyyr	1325	5	known	know	VBN
cord-006860-a3b8hyyr	1325	6	to	to	TO
cord-006860-a3b8hyyr	1325	7	produce	produce	VB
cord-006860-a3b8hyyr	1325	8	polytherapeutic	polytherapeutic	JJ
cord-006860-a3b8hyyr	1325	9	effects	effect	NNS
cord-006860-a3b8hyyr	1325	10	owing	owe	VBG
cord-006860-a3b8hyyr	1325	11	to	to	IN
cord-006860-a3b8hyyr	1325	12	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1325	13	multicomponent	multicomponent	JJ
cord-006860-a3b8hyyr	1325	14	nature	nature	NN
cord-006860-a3b8hyyr	1325	15	,	,	,
cord-006860-a3b8hyyr	1325	16	the	the	DT
cord-006860-a3b8hyyr	1325	17	exact	exact	JJ
cord-006860-a3b8hyyr	1325	18	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	1325	19	of	of	IN
cord-006860-a3b8hyyr	1325	20	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1325	21	anti	anti	JJ
cord-006860-a3b8hyyr	1325	22	-	-	JJ
cord-006860-a3b8hyyr	1325	23	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	1325	24	effects	effect	NNS
cord-006860-a3b8hyyr	1325	25	remain	remain	VBP
cord-006860-a3b8hyyr	1325	26	unknown	unknown	JJ
cord-006860-a3b8hyyr	1325	27	at	at	IN
cord-006860-a3b8hyyr	1325	28	this	this	DT
cord-006860-a3b8hyyr	1325	29	time	time	NN
cord-006860-a3b8hyyr	1325	30	.	.	.
cord-006860-a3b8hyyr	1326	1	Since	since	IN
cord-006860-a3b8hyyr	1326	2	defibrotide	defibrotide	NNP
cord-006860-a3b8hyyr	1326	3	is	be	VBZ
cord-006860-a3b8hyyr	1326	4	found	find	VBN
cord-006860-a3b8hyyr	1326	5	to	to	TO
cord-006860-a3b8hyyr	1326	6	be	be	VB
cord-006860-a3b8hyyr	1326	7	effective	effective	JJ
cord-006860-a3b8hyyr	1326	8	in	in	IN
cord-006860-a3b8hyyr	1326	9	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	1326	10	disorders	disorder	NNS
cord-006860-a3b8hyyr	1326	11	such	such	JJ
cord-006860-a3b8hyyr	1326	12	as	as	IN
cord-006860-a3b8hyyr	1326	13	PAOD	PAOD	NNP
cord-006860-a3b8hyyr	1326	14	,	,	,
cord-006860-a3b8hyyr	1326	15	VOD	VOD	NNP
cord-006860-a3b8hyyr	1326	16	related	relate	VBD
cord-006860-a3b8hyyr	1326	17	occlusive	occlusive	JJ
cord-006860-a3b8hyyr	1326	18	disorders	disorder	NNS
cord-006860-a3b8hyyr	1326	19	and	and	CC
cord-006860-a3b8hyyr	1326	20	related	relate	VBN
cord-006860-a3b8hyyr	1326	21	rnicroangiopathic	rnicroangiopathic	JJ
cord-006860-a3b8hyyr	1326	22	conditions	condition	NNS
cord-006860-a3b8hyyr	1326	23	,	,	,
cord-006860-a3b8hyyr	1326	24	we	-PRON-	PRP
cord-006860-a3b8hyyr	1326	25	studied	study	VBD
cord-006860-a3b8hyyr	1326	26	the	the	DT
cord-006860-a3b8hyyr	1326	27	effect	effect	NN
cord-006860-a3b8hyyr	1326	28	of	of	IN
cord-006860-a3b8hyyr	1326	29	this	this	DT
cord-006860-a3b8hyyr	1326	30	drug	drug	NN
cord-006860-a3b8hyyr	1326	31	on	on	IN
cord-006860-a3b8hyyr	1326	32	the	the	DT
cord-006860-a3b8hyyr	1326	33	contraction	contraction	NN
cord-006860-a3b8hyyr	1326	34	of	of	IN
cord-006860-a3b8hyyr	1326	35	dog	dog	NN
cord-006860-a3b8hyyr	1326	36	and	and	CC
cord-006860-a3b8hyyr	1326	37	pig	pig	NN
cord-006860-a3b8hyyr	1326	38	arterial	arterial	JJ
cord-006860-a3b8hyyr	1326	39	strip	strip	NNP
cord-006860-a3b8hyyr	1326	40	/	/	SYM
cord-006860-a3b8hyyr	1326	41	rings	ring	NNS
cord-006860-a3b8hyyr	1326	42	obtained	obtain	VBN
cord-006860-a3b8hyyr	1326	43	from	from	IN
cord-006860-a3b8hyyr	1326	44	various	various	JJ
cord-006860-a3b8hyyr	1326	45	sites	site	NNS
cord-006860-a3b8hyyr	1326	46	.	.	.
cord-006860-a3b8hyyr	1327	1	In	in	IN
cord-006860-a3b8hyyr	1327	2	vitro	vitro	FW
cord-006860-a3b8hyyr	1327	3	supplementation	supplementation	NN
cord-006860-a3b8hyyr	1327	4	ofdefibrotide	ofdefibrotide	NN
cord-006860-a3b8hyyr	1327	5	to	to	IN
cord-006860-a3b8hyyr	1327	6	the	the	DT
cord-006860-a3b8hyyr	1327	7	organ	organ	NN
cord-006860-a3b8hyyr	1327	8	bath	bath	NN
cord-006860-a3b8hyyr	1327	9	containing	contain	VBG
cord-006860-a3b8hyyr	1327	10	control	control	NNP
cord-006860-a3b8hyyr	1327	11	dog	dog	NN
cord-006860-a3b8hyyr	1327	12	and	and	CC
cord-006860-a3b8hyyr	1327	13	pig	pig	NN
cord-006860-a3b8hyyr	1327	14	arterial	arterial	JJ
cord-006860-a3b8hyyr	1327	15	rings	ring	NNS
cord-006860-a3b8hyyr	1327	16	did	do	VBD
cord-006860-a3b8hyyr	1327	17	not	not	RB
cord-006860-a3b8hyyr	1327	18	modulate	modulate	VB
cord-006860-a3b8hyyr	1327	19	the	the	DT
cord-006860-a3b8hyyr	1327	20	serotonin	serotonin	NN
cord-006860-a3b8hyyr	1327	21	and	and	CC
cord-006860-a3b8hyyr	1327	22	thromboxane	thromboxane	NN
cord-006860-a3b8hyyr	1327	23	(	(	-LRB-
cord-006860-a3b8hyyr	1327	24	generated	generate	VBN
cord-006860-a3b8hyyr	1327	25	)	)	-RRB-
cord-006860-a3b8hyyr	1327	26	contraction	contraction	NN
cord-006860-a3b8hyyr	1327	27	,	,	,
cord-006860-a3b8hyyr	1327	28	however	however	RB
cord-006860-a3b8hyyr	1327	29	,	,	,
cord-006860-a3b8hyyr	1327	30	tissues	tissue	NNS
cord-006860-a3b8hyyr	1327	31	obtained	obtain	VBN
cord-006860-a3b8hyyr	1327	32	from	from	IN
cord-006860-a3b8hyyr	1327	33	dogs	dog	NNS
cord-006860-a3b8hyyr	1327	34	treated	treat	VBN
cord-006860-a3b8hyyr	1327	35	with	with	IN
cord-006860-a3b8hyyr	1327	36	10	10	CD
cord-006860-a3b8hyyr	1327	37	mg	mg	NNP
cord-006860-a3b8hyyr	1327	38	/	/	SYM
cord-006860-a3b8hyyr	1327	39	kg	kg	NNP
cord-006860-a3b8hyyr	1327	40	defibrotide	defibrotide	NN
cord-006860-a3b8hyyr	1327	41	IV	IV	NNP
cord-006860-a3b8hyyr	1327	42	exhibited	exhibit	VBD
cord-006860-a3b8hyyr	1327	43	a	a	DT
cord-006860-a3b8hyyr	1327	44	profound	profound	JJ
cord-006860-a3b8hyyr	1327	45	desensitization	desensitization	NN
cord-006860-a3b8hyyr	1327	46	to	to	IN
cord-006860-a3b8hyyr	1327	47	the	the	DT
cord-006860-a3b8hyyr	1327	48	agonist	agonist	NN
cord-006860-a3b8hyyr	1327	49	induced	induce	VBN
cord-006860-a3b8hyyr	1327	50	contractile	contractile	JJ
cord-006860-a3b8hyyr	1327	51	process	process	NN
cord-006860-a3b8hyyr	1327	52	.	.	.
cord-006860-a3b8hyyr	1328	1	The	the	DT
cord-006860-a3b8hyyr	1328	2	time	time	NN
cord-006860-a3b8hyyr	1328	3	course	course	NN
cord-006860-a3b8hyyr	1328	4	of	of	IN
cord-006860-a3b8hyyr	1328	5	these	these	DT
cord-006860-a3b8hyyr	1328	6	effects	effect	NNS
cord-006860-a3b8hyyr	1328	7	was	be	VBD
cord-006860-a3b8hyyr	1328	8	found	find	VBN
cord-006860-a3b8hyyr	1328	9	to	to	TO
cord-006860-a3b8hyyr	1328	10	be	be	VB
cord-006860-a3b8hyyr	1328	11	much	much	RB
cord-006860-a3b8hyyr	1328	12	larger	large	JJR
cord-006860-a3b8hyyr	1328	13	than	than	IN
cord-006860-a3b8hyyr	1328	14	the	the	DT
cord-006860-a3b8hyyr	1328	15	plasma	plasma	NN
cord-006860-a3b8hyyr	1328	16	half	half	JJ
cord-006860-a3b8hyyr	1328	17	-	-	HYPH
cord-006860-a3b8hyyr	1328	18	life	life	NN
cord-006860-a3b8hyyr	1328	19	of	of	IN
cord-006860-a3b8hyyr	1328	20	defibrotide	defibrotide	NN
cord-006860-a3b8hyyr	1328	21	.	.	.
cord-006860-a3b8hyyr	1329	1	This	this	DT
cord-006860-a3b8hyyr	1329	2	presentation	presentation	NN
cord-006860-a3b8hyyr	1329	3	will	will	MD
cord-006860-a3b8hyyr	1329	4	provide	provide	VB
cord-006860-a3b8hyyr	1329	5	additional	additional	JJ
cord-006860-a3b8hyyr	1329	6	data	datum	NNS
cord-006860-a3b8hyyr	1329	7	on	on	IN
cord-006860-a3b8hyyr	1329	8	the	the	DT
cord-006860-a3b8hyyr	1329	9	effect	effect	NN
cord-006860-a3b8hyyr	1329	10	of	of	IN
cord-006860-a3b8hyyr	1329	11	defibrotide	defibrotide	NN
cord-006860-a3b8hyyr	1329	12	on	on	IN
cord-006860-a3b8hyyr	1329	13	the	the	DT
cord-006860-a3b8hyyr	1329	14	contraction	contraction	NN
cord-006860-a3b8hyyr	1329	15	of	of	IN
cord-006860-a3b8hyyr	1329	16	vascular	vascular	JJ
cord-006860-a3b8hyyr	1329	17	smooth	smooth	JJ
cord-006860-a3b8hyyr	1329	18	muscles	muscle	NNS
cord-006860-a3b8hyyr	1329	19	as	as	IN
cord-006860-a3b8hyyr	1329	20	a	a	DT
cord-006860-a3b8hyyr	1329	21	possible	possible	JJ
cord-006860-a3b8hyyr	1329	22	explanation	explanation	NN
cord-006860-a3b8hyyr	1329	23	for	for	IN
cord-006860-a3b8hyyr	1329	24	the	the	DT
cord-006860-a3b8hyyr	1329	25	anti	anti	JJ
cord-006860-a3b8hyyr	1329	26	-	-	JJ
cord-006860-a3b8hyyr	1329	27	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	1329	28	effects	effect	NNS
cord-006860-a3b8hyyr	1329	29	of	of	IN
cord-006860-a3b8hyyr	1329	30	defibrotide	defibrotide	NN
cord-006860-a3b8hyyr	1329	31	.	.	.
cord-006860-a3b8hyyr	1330	1	A.	A.	NNP
cord-006860-a3b8hyyr	1330	2	Wehmeier	Wehmeier	NNP
cord-006860-a3b8hyyr	1330	3	,	,	,
cord-006860-a3b8hyyr	1330	4	A.	A.	NNP
cord-006860-a3b8hyyr	1330	5	Popescu	Popescu	NNP
cord-006860-a3b8hyyr	1330	6	,	,	,
cord-006860-a3b8hyyr	1330	7	W.	W.	NNP
cord-006860-a3b8hyyr	1330	8	Schneider	Schneider	NNP
cord-006860-a3b8hyyr	1330	9	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	1330	10	for	for	IN
cord-006860-a3b8hyyr	1330	11	H,~matologie	H,~matologie	VBG
cord-006860-a3b8hyyr	1330	12	,	,	,
cord-006860-a3b8hyyr	1330	13	Onkologie	Onkologie	NNP
cord-006860-a3b8hyyr	1330	14	und	und	IN
cord-006860-a3b8hyyr	1330	15	klinische	klinische	NNP
cord-006860-a3b8hyyr	1330	16	Immunologie	Immunologie	NNP
cord-006860-a3b8hyyr	1330	17	der	der	NNP
cord-006860-a3b8hyyr	1330	18	Heinrich	Heinrich	NNP
cord-006860-a3b8hyyr	1330	19	-	-	HYPH
cord-006860-a3b8hyyr	1330	20	Heine-	Heine-	NNP
cord-006860-a3b8hyyr	1331	1	Universit&t	Universit&t	NNP
cord-006860-a3b8hyyr	1331	2	D0sseldorf	D0sseldorf	NNP
cord-006860-a3b8hyyr	1332	1	In	in	IN
cord-006860-a3b8hyyr	1332	2	chronic	chronic	JJ
cord-006860-a3b8hyyr	1332	3	myeloid	myeloid	NN
cord-006860-a3b8hyyr	1332	4	leukemia	leukemia	NN
cord-006860-a3b8hyyr	1332	5	(	(	-LRB-
cord-006860-a3b8hyyr	1332	6	CML	CML	NNP
cord-006860-a3b8hyyr	1332	7	)	)	-RRB-
cord-006860-a3b8hyyr	1332	8	,	,	,
cord-006860-a3b8hyyr	1332	9	evolution	evolution	NN
cord-006860-a3b8hyyr	1332	10	of	of	IN
cord-006860-a3b8hyyr	1332	11	blast	blast	NN
cord-006860-a3b8hyyr	1332	12	crisis	crisis	NN
cord-006860-a3b8hyyr	1332	13	is	be	VBZ
cord-006860-a3b8hyyr	1332	14	the	the	DT
cord-006860-a3b8hyyr	1332	15	limiting	limit	VBG
cord-006860-a3b8hyyr	1332	16	factor	factor	NN
cord-006860-a3b8hyyr	1332	17	of	of	IN
cord-006860-a3b8hyyr	1332	18	survival	survival	NN
cord-006860-a3b8hyyr	1332	19	.	.	.
cord-006860-a3b8hyyr	1333	1	However	however	RB
cord-006860-a3b8hyyr	1333	2	,	,	,
cord-006860-a3b8hyyr	1333	3	as	as	IN
cord-006860-a3b8hyyr	1333	4	in	in	IN
cord-006860-a3b8hyyr	1333	5	other	other	JJ
cord-006860-a3b8hyyr	1333	6	chronic	chronic	JJ
cord-006860-a3b8hyyr	1333	7	myeloproliferative	myeloproliferative	JJ
cord-006860-a3b8hyyr	1333	8	disorders	disorder	NNS
cord-006860-a3b8hyyr	1333	9	,	,	,
cord-006860-a3b8hyyr	1333	10	bleeding	bleeding	NN
cord-006860-a3b8hyyr	1333	11	and	and	CC
cord-006860-a3b8hyyr	1333	12	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	1333	13	complications	complication	NNS
cord-006860-a3b8hyyr	1333	14	are	be	VBP
cord-006860-a3b8hyyr	1333	15	a	a	DT
cord-006860-a3b8hyyr	1333	16	major	major	JJ
cord-006860-a3b8hyyr	1333	17	source	source	NN
cord-006860-a3b8hyyr	1333	18	of	of	IN
cord-006860-a3b8hyyr	1333	19	morbidity	morbidity	NN
cord-006860-a3b8hyyr	1333	20	but	but	CC
cord-006860-a3b8hyyr	1333	21	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1333	22	incidence	incidence	NN
cord-006860-a3b8hyyr	1333	23	has	have	VBZ
cord-006860-a3b8hyyr	1333	24	rarely	rarely	RB
cord-006860-a3b8hyyr	1333	25	been	be	VBN
cord-006860-a3b8hyyr	1333	26	analysed	analyse	VBN
cord-006860-a3b8hyyr	1333	27	in	in	IN
cord-006860-a3b8hyyr	1333	28	larger	large	JJR
cord-006860-a3b8hyyr	1333	29	patient	patient	NN
cord-006860-a3b8hyyr	1333	30	groups	group	NNS
cord-006860-a3b8hyyr	1333	31	.	.	.
cord-006860-a3b8hyyr	1334	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1334	2	retrospectively	retrospectively	RB
cord-006860-a3b8hyyr	1334	3	evaluated	evaluate	VBD
cord-006860-a3b8hyyr	1334	4	182	182	CD
cord-006860-a3b8hyyr	1334	5	patients	patient	NNS
cord-006860-a3b8hyyr	1334	6	with	with	IN
cord-006860-a3b8hyyr	1334	7	CML	CML	NNP
cord-006860-a3b8hyyr	1334	8	during	during	IN
cord-006860-a3b8hyyr	1334	9	chronic	chronic	JJ
cord-006860-a3b8hyyr	1334	10	phase	phase	NN
cord-006860-a3b8hyyr	1334	11	(	(	-LRB-
cord-006860-a3b8hyyr	1334	12	170	170	CD
cord-006860-a3b8hyyr	1334	13	cases	case	NNS
cord-006860-a3b8hyyr	1334	14	)	)	-RRB-
cord-006860-a3b8hyyr	1334	15	,	,	,
cord-006860-a3b8hyyr	1334	16	accelerated	accelerated	JJ
cord-006860-a3b8hyyr	1334	17	disease	disease	NN
cord-006860-a3b8hyyr	1334	18	(	(	-LRB-
cord-006860-a3b8hyyr	1334	19	58	58	CD
cord-006860-a3b8hyyr	1334	20	cases	case	NNS
cord-006860-a3b8hyyr	1334	21	)	)	-RRB-
cord-006860-a3b8hyyr	1334	22	,	,	,
cord-006860-a3b8hyyr	1334	23	and	and	CC
cord-006860-a3b8hyyr	1334	24	blast	blast	NN
cord-006860-a3b8hyyr	1334	25	cdsis	cdsis	NNP
cord-006860-a3b8hyyr	1334	26	(	(	-LRB-
cord-006860-a3b8hyyr	1334	27	72	72	CD
cord-006860-a3b8hyyr	1334	28	cases	case	NNS
cord-006860-a3b8hyyr	1334	29	)	)	-RRB-
cord-006860-a3b8hyyr	1334	30	,	,	,
cord-006860-a3b8hyyr	1334	31	and	and	CC
cord-006860-a3b8hyyr	1334	32	determined	determine	VBD
cord-006860-a3b8hyyr	1334	33	the	the	DT
cord-006860-a3b8hyyr	1334	34	incidence	incidence	NN
cord-006860-a3b8hyyr	1334	35	of	of	IN
cord-006860-a3b8hyyr	1334	36	thrombohemorrhagic	thrombohemorrhagic	JJ
cord-006860-a3b8hyyr	1334	37	complications	complication	NNS
cord-006860-a3b8hyyr	1334	38	in	in	IN
cord-006860-a3b8hyyr	1334	39	relation	relation	NN
cord-006860-a3b8hyyr	1334	40	to	to	IN
cord-006860-a3b8hyyr	1334	41	the	the	DT
cord-006860-a3b8hyyr	1334	42	stage	stage	NN
cord-006860-a3b8hyyr	1334	43	of	of	IN
cord-006860-a3b8hyyr	1334	44	the	the	DT
cord-006860-a3b8hyyr	1334	45	disease	disease	NN
cord-006860-a3b8hyyr	1334	46	.	.	.
cord-006860-a3b8hyyr	1335	1	In	in	IN
cord-006860-a3b8hyyr	1335	2	chronic	chronic	JJ
cord-006860-a3b8hyyr	1335	3	phase	phase	NN
cord-006860-a3b8hyyr	1335	4	,	,	,
cord-006860-a3b8hyyr	1335	5	28	28	CD
cord-006860-a3b8hyyr	1335	6	patients	patient	NNS
cord-006860-a3b8hyyr	1335	7	had	have	VBD
cord-006860-a3b8hyyr	1335	8	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1335	9	complications	complication	NNS
cord-006860-a3b8hyyr	1335	10	(	(	-LRB-
cord-006860-a3b8hyyr	1335	11	8.4%/patient	8.4%/patient	CD
cord-006860-a3b8hyyr	1335	12	year	year	NN
cord-006860-a3b8hyyr	1335	13	)	)	-RRB-
cord-006860-a3b8hyyr	1335	14	and	and	CC
cord-006860-a3b8hyyr	1335	15	15	15	CD
cord-006860-a3b8hyyr	1335	16	patients	patient	NNS
cord-006860-a3b8hyyr	1335	17	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	1335	18	episodes	episode	NNS
cord-006860-a3b8hyyr	1335	19	(	(	-LRB-
cord-006860-a3b8hyyr	1335	20	4%/patient	4%/patient	CD
cord-006860-a3b8hyyr	1335	21	year	year	NN
cord-006860-a3b8hyyr	1335	22	)	)	-RRB-
cord-006860-a3b8hyyr	1335	23	.	.	.
cord-006860-a3b8hyyr	1336	1	The	the	DT
cord-006860-a3b8hyyr	1336	2	incidence	incidence	NN
cord-006860-a3b8hyyr	1336	3	of	of	IN
cord-006860-a3b8hyyr	1336	4	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1336	5	increased	increase	VBD
cord-006860-a3b8hyyr	1336	6	significantly	significantly	RB
cord-006860-a3b8hyyr	1336	7	in	in	IN
cord-006860-a3b8hyyr	1336	8	accelerated	accelerated	JJ
cord-006860-a3b8hyyr	1336	9	disease	disease	NN
cord-006860-a3b8hyyr	1336	10	(	(	-LRB-
cord-006860-a3b8hyyr	1336	11	18	18	CD
cord-006860-a3b8hyyr	1336	12	patients	patient	NNS
cord-006860-a3b8hyyr	1336	13	,	,	,
cord-006860-a3b8hyyr	1336	14	51.2%/patient	51.2%/patient	NN
cord-006860-a3b8hyyr	1336	15	year	year	NN
cord-006860-a3b8hyyr	1336	16	)	)	-RRB-
cord-006860-a3b8hyyr	1336	17	and	and	CC
cord-006860-a3b8hyyr	1336	18	blast	blast	NN
cord-006860-a3b8hyyr	1336	19	crisis	crisis	NN
cord-006860-a3b8hyyr	1336	20	(	(	-LRB-
cord-006860-a3b8hyyr	1336	21	37	37	CD
cord-006860-a3b8hyyr	1336	22	patients	patient	NNS
cord-006860-a3b8hyyr	1336	23	,	,	,
cord-006860-a3b8hyyr	1336	24	347%/patient	347%/patient	NNP
cord-006860-a3b8hyyr	1336	25	year	year	NN
cord-006860-a3b8hyyr	1336	26	)	)	-RRB-
cord-006860-a3b8hyyr	1336	27	,	,	,
cord-006860-a3b8hyyr	1336	28	and	and	CC
cord-006860-a3b8hyyr	1336	29	many	many	JJ
cord-006860-a3b8hyyr	1336	30	patients	patient	NNS
cord-006860-a3b8hyyr	1336	31	had	have	VBD
cord-006860-a3b8hyyr	1336	32	repeated	repeat	VBN
cord-006860-a3b8hyyr	1336	33	complications	complication	NNS
cord-006860-a3b8hyyr	1336	34	.	.	.
cord-006860-a3b8hyyr	1337	1	Contrary	contrary	JJ
cord-006860-a3b8hyyr	1337	2	to	to	IN
cord-006860-a3b8hyyr	1337	3	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1337	4	expectations	expectation	NNS
cord-006860-a3b8hyyr	1337	5	,	,	,
cord-006860-a3b8hyyr	1337	6	the	the	DT
cord-006860-a3b8hyyr	1337	7	incidence	incidence	NN
cord-006860-a3b8hyyr	1337	8	of	of	IN
cord-006860-a3b8hyyr	1337	9	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	1337	10	complications	complication	NNS
cord-006860-a3b8hyyr	1337	11	also	also	RB
cord-006860-a3b8hyyr	1337	12	increased	increase	VBD
cord-006860-a3b8hyyr	1337	13	to	to	IN
cord-006860-a3b8hyyr	1337	14	10.2%/patient	10.2%/patient	NN
cord-006860-a3b8hyyr	1337	15	year	year	NN
cord-006860-a3b8hyyr	1337	16	in	in	IN
cord-006860-a3b8hyyr	1337	17	accelerated	accelerated	JJ
cord-006860-a3b8hyyr	1337	18	phase	phase	NN
cord-006860-a3b8hyyr	1337	19	and	and	CC
cord-006860-a3b8hyyr	1337	20	39.8	39.8	CD
cord-006860-a3b8hyyr	1337	21	%	%	NN
cord-006860-a3b8hyyr	1337	22	/patient	/patient	NNP
cord-006860-a3b8hyyr	1337	23	year	year	NN
cord-006860-a3b8hyyr	1337	24	in	in	IN
cord-006860-a3b8hyyr	1337	25	blast	blast	NN
cord-006860-a3b8hyyr	1337	26	crisis	crisis	NN
cord-006860-a3b8hyyr	1337	27	,	,	,
cord-006860-a3b8hyyr	1337	28	tn	tn	NNP
cord-006860-a3b8hyyr	1337	29	chronic	chronic	NN
cord-006860-a3b8hyyr	1337	30	phase	phase	NN
cord-006860-a3b8hyyr	1337	31	,	,	,
cord-006860-a3b8hyyr	1337	32	3	3	CD
cord-006860-a3b8hyyr	1337	33	patients	patient	NNS
cord-006860-a3b8hyyr	1337	34	died	die	VBD
cord-006860-a3b8hyyr	1337	35	because	because	IN
cord-006860-a3b8hyyr	1337	36	of	of	IN
cord-006860-a3b8hyyr	1337	37	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1337	38	events	event	NNS
cord-006860-a3b8hyyr	1337	39	.	.	.
cord-006860-a3b8hyyr	1338	1	In	in	IN
cord-006860-a3b8hyyr	1338	2	accelerated	accelerated	JJ
cord-006860-a3b8hyyr	1338	3	phase	phase	NN
cord-006860-a3b8hyyr	1338	4	,	,	,
cord-006860-a3b8hyyr	1338	5	5	5	CD
cord-006860-a3b8hyyr	1338	6	patients	patient	NNS
cord-006860-a3b8hyyr	1338	7	died	die	VBD
cord-006860-a3b8hyyr	1338	8	due	due	IN
cord-006860-a3b8hyyr	1338	9	to	to	IN
cord-006860-a3b8hyyr	1338	10	bleeding	bleeding	NN
cord-006860-a3b8hyyr	1338	11	and	and	CC
cord-006860-a3b8hyyr	1338	12	1	1	CD
cord-006860-a3b8hyyr	1338	13	patient	patient	NN
cord-006860-a3b8hyyr	1338	14	due	due	IN
cord-006860-a3b8hyyr	1338	15	to	to	IN
cord-006860-a3b8hyyr	1338	16	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	1338	17	complications	complication	NNS
cord-006860-a3b8hyyr	1338	18	.	.	.
cord-006860-a3b8hyyr	1339	1	In	in	IN
cord-006860-a3b8hyyr	1339	2	blast	blast	NN
cord-006860-a3b8hyyr	1339	3	crisis	crisis	NN
cord-006860-a3b8hyyr	1339	4	,	,	,
cord-006860-a3b8hyyr	1339	5	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1339	6	was	be	VBD
cord-006860-a3b8hyyr	1339	7	associated	associate	VBN
cord-006860-a3b8hyyr	1339	8	with	with	IN
cord-006860-a3b8hyyr	1339	9	21	21	CD
cord-006860-a3b8hyyr	1339	10	deaths	death	NNS
cord-006860-a3b8hyyr	1339	11	,	,	,
cord-006860-a3b8hyyr	1339	12	and	and	CC
cord-006860-a3b8hyyr	1339	13	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	1339	14	embolism	embolism	NN
cord-006860-a3b8hyyr	1339	15	with	with	IN
cord-006860-a3b8hyyr	1339	16	2	2	CD
cord-006860-a3b8hyyr	1339	17	deaths	death	NNS
cord-006860-a3b8hyyr	1339	18	.	.	.
cord-006860-a3b8hyyr	1340	1	Analysis	analysis	NN
cord-006860-a3b8hyyr	1340	2	of	of	IN
cord-006860-a3b8hyyr	1340	3	the	the	DT
cord-006860-a3b8hyyr	1340	4	cause	cause	NN
cord-006860-a3b8hyyr	1340	5	of	of	IN
cord-006860-a3b8hyyr	1340	6	thrombohemorrhagic	thrombohemorrhagic	JJ
cord-006860-a3b8hyyr	1340	7	complications	complication	NNS
cord-006860-a3b8hyyr	1340	8	revealed	reveal	VBD
cord-006860-a3b8hyyr	1340	9	that	that	IN
cord-006860-a3b8hyyr	1340	10	in	in	IN
cord-006860-a3b8hyyr	1340	11	chronic	chronic	JJ
cord-006860-a3b8hyyr	1340	12	phase	phase	NN
cord-006860-a3b8hyyr	1340	13	,	,	,
cord-006860-a3b8hyyr	1340	14	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1340	15	was	be	VBD
cord-006860-a3b8hyyr	1340	16	often	often	RB
cord-006860-a3b8hyyr	1340	17	associated	associate	VBN
cord-006860-a3b8hyyr	1340	18	with	with	IN
cord-006860-a3b8hyyr	1340	19	uncontrolled	uncontrolled	JJ
cord-006860-a3b8hyyr	1340	20	busutfan	busutfan	NN
cord-006860-a3b8hyyr	1340	21	therapy	therapy	NN
cord-006860-a3b8hyyr	1340	22	,	,	,
cord-006860-a3b8hyyr	1340	23	whereas	whereas	IN
cord-006860-a3b8hyyr	1340	24	in	in	IN
cord-006860-a3b8hyyr	1340	25	blast	blast	NN
cord-006860-a3b8hyyr	1340	26	crisis	crisis	NN
cord-006860-a3b8hyyr	1340	27	,	,	,
cord-006860-a3b8hyyr	1340	28	severe	severe	JJ
cord-006860-a3b8hyyr	1340	29	bleeding	bleeding	NN
cord-006860-a3b8hyyr	1340	30	occurred	occur	VBD
cord-006860-a3b8hyyr	1340	31	mainly	mainly	RB
cord-006860-a3b8hyyr	1340	32	when	when	WRB
cord-006860-a3b8hyyr	1340	33	platelet	platelet	NN
cord-006860-a3b8hyyr	1340	34	counts	count	NNS
cord-006860-a3b8hyyr	1340	35	were	be	VBD
cord-006860-a3b8hyyr	1340	36	low	low	JJ
cord-006860-a3b8hyyr	1340	37	and	and	CC
cord-006860-a3b8hyyr	1340	38	peripheral	peripheral	JJ
cord-006860-a3b8hyyr	1340	39	blasts	blast	NNS
cord-006860-a3b8hyyr	1340	40	increased	increase	VBD
cord-006860-a3b8hyyr	1340	41	.	.	.
cord-006860-a3b8hyyr	1341	1	However	however	RB
cord-006860-a3b8hyyr	1341	2	,	,	,
cord-006860-a3b8hyyr	1341	3	there	there	EX
cord-006860-a3b8hyyr	1341	4	was	be	VBD
cord-006860-a3b8hyyr	1341	5	no	no	DT
cord-006860-a3b8hyyr	1341	6	obvious	obvious	JJ
cord-006860-a3b8hyyr	1341	7	explanation	explanation	NN
cord-006860-a3b8hyyr	1341	8	for	for	IN
cord-006860-a3b8hyyr	1341	9	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	1341	10	complications	complication	NNS
cord-006860-a3b8hyyr	1341	11	.	.	.
cord-006860-a3b8hyyr	1342	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1342	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	1342	3	that	that	IN
cord-006860-a3b8hyyr	1342	4	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1342	5	and	and	CC
cord-006860-a3b8hyyr	1342	6	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	1342	7	complications	complication	NNS
cord-006860-a3b8hyyr	1342	8	are	be	VBP
cord-006860-a3b8hyyr	1342	9	a	a	DT
cord-006860-a3b8hyyr	1342	10	major	major	JJ
cord-006860-a3b8hyyr	1342	11	source	source	NN
cord-006860-a3b8hyyr	1342	12	of	of	IN
cord-006860-a3b8hyyr	1342	13	morbidity	morbidity	NN
cord-006860-a3b8hyyr	1342	14	and	and	CC
cord-006860-a3b8hyyr	1342	15	mortality	mortality	NN
cord-006860-a3b8hyyr	1342	16	also	also	RB
cord-006860-a3b8hyyr	1342	17	in	in	IN
cord-006860-a3b8hyyr	1342	18	CML	CML	NNP
cord-006860-a3b8hyyr	1342	19	,	,	,
cord-006860-a3b8hyyr	1342	20	and	and	CC
cord-006860-a3b8hyyr	1342	21	that	that	IN
cord-006860-a3b8hyyr	1342	22	the	the	DT
cord-006860-a3b8hyyr	1342	23	incidence	incidence	NN
cord-006860-a3b8hyyr	1342	24	of	of	IN
cord-006860-a3b8hyyr	1342	25	such	such	JJ
cord-006860-a3b8hyyr	1342	26	complications	complication	NNS
cord-006860-a3b8hyyr	1342	27	increase	increase	VBP
cord-006860-a3b8hyyr	1342	28	in	in	IN
cord-006860-a3b8hyyr	1342	29	advanced	advanced	JJ
cord-006860-a3b8hyyr	1342	30	stages	stage	NNS
cord-006860-a3b8hyyr	1342	31	of	of	IN
cord-006860-a3b8hyyr	1342	32	the	the	DT
cord-006860-a3b8hyyr	1342	33	disease	disease	NN
cord-006860-a3b8hyyr	1342	34	.	.	.
cord-006860-a3b8hyyr	1343	1	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	1343	2	for	for	IN
cord-006860-a3b8hyyr	1343	3	Innere	Innere	NNP
cord-006860-a3b8hyyr	1343	4	Medizin	Medizin	NNP
cord-006860-a3b8hyyr	1343	5	°	°	NN
cord-006860-a3b8hyyr	1343	6	,	,	,
cord-006860-a3b8hyyr	1343	7	Klinikum	Klinikum	NNP
cord-006860-a3b8hyyr	1343	8	Schwerin	Schwerin	NNP
cord-006860-a3b8hyyr	1343	9	Patients	patient	NNS
cord-006860-a3b8hyyr	1343	10	suffering	suffer	VBG
cord-006860-a3b8hyyr	1343	11	from	from	IN
cord-006860-a3b8hyyr	1343	12	primary	primary	JJ
cord-006860-a3b8hyyr	1343	13	or	or	CC
cord-006860-a3b8hyyr	1343	14	secondary	secondary	JJ
cord-006860-a3b8hyyr	1343	15	amyloidosis	amyloidosis	NN
cord-006860-a3b8hyyr	1343	16	may	may	MD
cord-006860-a3b8hyyr	1343	17	occasionally	occasionally	RB
cord-006860-a3b8hyyr	1343	18	acquire	acquire	VB
cord-006860-a3b8hyyr	1343	19	a	a	DT
cord-006860-a3b8hyyr	1343	20	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1343	21	disorder	disorder	NN
cord-006860-a3b8hyyr	1343	22	characterised	characterise	VBN
cord-006860-a3b8hyyr	1343	23	by	by	IN
cord-006860-a3b8hyyr	1343	24	isolated	isolate	VBN
cord-006860-a3b8hyyr	1343	25	factor	factor	NN
cord-006860-a3b8hyyr	1343	26	X	x	NN
cord-006860-a3b8hyyr	1343	27	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1343	28	.	.	.
cord-006860-a3b8hyyr	1344	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1344	2	report	report	VBP
cord-006860-a3b8hyyr	1344	3	on	on	IN
cord-006860-a3b8hyyr	1344	4	a	a	DT
cord-006860-a3b8hyyr	1344	5	60-years	60-years	CD
cord-006860-a3b8hyyr	1344	6	-	-	HYPH
cord-006860-a3b8hyyr	1344	7	old	old	JJ
cord-006860-a3b8hyyr	1344	8	man	man	NN
cord-006860-a3b8hyyr	1344	9	who	who	WP
cord-006860-a3b8hyyr	1344	10	presented	present	VBD
cord-006860-a3b8hyyr	1344	11	with	with	IN
cord-006860-a3b8hyyr	1344	12	lower	low	JJR
cord-006860-a3b8hyyr	1344	13	gastrointestinal	gastrointestinal	JJ
cord-006860-a3b8hyyr	1344	14	bleeding	bleeding	NN
cord-006860-a3b8hyyr	1344	15	and	and	CC
cord-006860-a3b8hyyr	1344	16	prolonged	prolonged	JJ
cord-006860-a3b8hyyr	1344	17	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	1344	18	time	time	NN
cord-006860-a3b8hyyr	1344	19	(	(	-LRB-
cord-006860-a3b8hyyr	1344	20	Quick	Quick	NNP
cord-006860-a3b8hyyr	1344	21	50	50	CD
cord-006860-a3b8hyyr	1344	22	%	%	NN
cord-006860-a3b8hyyr	1344	23	)	)	-RRB-
cord-006860-a3b8hyyr	1344	24	.	.	.
cord-006860-a3b8hyyr	1345	1	Amyloidosis	Amyloidosis	NNP
cord-006860-a3b8hyyr	1345	2	was	be	VBD
cord-006860-a3b8hyyr	1345	3	suspected	suspect	VBN
cord-006860-a3b8hyyr	1345	4	and	and	CC
cord-006860-a3b8hyyr	1345	5	proven	prove	VBN
cord-006860-a3b8hyyr	1345	6	using	use	VBG
cord-006860-a3b8hyyr	1345	7	biopsy	biopsy	NN
cord-006860-a3b8hyyr	1345	8	of	of	IN
cord-006860-a3b8hyyr	1345	9	the	the	DT
cord-006860-a3b8hyyr	1345	10	rectum	rectum	NN
cord-006860-a3b8hyyr	1345	11	and	and	CC
cord-006860-a3b8hyyr	1345	12	histological	histological	JJ
cord-006860-a3b8hyyr	1345	13	analysis	analysis	NN
cord-006860-a3b8hyyr	1345	14	.	.	.
cord-006860-a3b8hyyr	1346	1	In	in	IN
cord-006860-a3b8hyyr	1346	2	addition	addition	NN
cord-006860-a3b8hyyr	1346	3	,	,	,
cord-006860-a3b8hyyr	1346	4	a	a	DT
cord-006860-a3b8hyyr	1346	5	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	1346	6	gammopathy	gammopathy	NN
cord-006860-a3b8hyyr	1346	7	of	of	IN
cord-006860-a3b8hyyr	1346	8	undetermined	undetermined	JJ
cord-006860-a3b8hyyr	1346	9	significance	significance	NN
cord-006860-a3b8hyyr	1346	10	was	be	VBD
cord-006860-a3b8hyyr	1346	11	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	1346	12	by	by	IN
cord-006860-a3b8hyyr	1346	13	immunofixation	immunofixation	NN
cord-006860-a3b8hyyr	1346	14	(	(	-LRB-
cord-006860-a3b8hyyr	1346	15	light	light	JJ
cord-006860-a3b8hyyr	1346	16	chain	chain	NN
cord-006860-a3b8hyyr	1346	17	,	,	,
cord-006860-a3b8hyyr	1346	18	type	type	NN
cord-006860-a3b8hyyr	1346	19	X	x	NN
cord-006860-a3b8hyyr	1346	20	)	)	-RRB-
cord-006860-a3b8hyyr	1346	21	.	.	.
cord-006860-a3b8hyyr	1347	1	Detailed	detailed	JJ
cord-006860-a3b8hyyr	1347	2	investigation	investigation	NN
cord-006860-a3b8hyyr	1347	3	of	of	IN
cord-006860-a3b8hyyr	1347	4	the	the	DT
cord-006860-a3b8hyyr	1347	5	prolonged	prolonged	JJ
cord-006860-a3b8hyyr	1347	6	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	1347	7	time	time	NN
cord-006860-a3b8hyyr	1347	8	led	lead	VBD
cord-006860-a3b8hyyr	1347	9	to	to	IN
cord-006860-a3b8hyyr	1347	10	the	the	DT
cord-006860-a3b8hyyr	1347	11	discovery	discovery	NN
cord-006860-a3b8hyyr	1347	12	of	of	IN
cord-006860-a3b8hyyr	1347	13	a	a	DT
cord-006860-a3b8hyyr	1347	14	pronounced	pronounce	VBN
cord-006860-a3b8hyyr	1347	15	factor	factor	NN
cord-006860-a3b8hyyr	1347	16	X	x	NN
cord-006860-a3b8hyyr	1347	17	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1347	18	(	(	-LRB-
cord-006860-a3b8hyyr	1347	19	residual	residual	JJ
cord-006860-a3b8hyyr	1347	20	activity	activity	NN
cord-006860-a3b8hyyr	1347	21	4	4	CD
cord-006860-a3b8hyyr	1347	22	%	%	NN
cord-006860-a3b8hyyr	1347	23	)	)	-RRB-
cord-006860-a3b8hyyr	1347	24	.	.	.
cord-006860-a3b8hyyr	1348	1	Inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1348	2	of	of	IN
cord-006860-a3b8hyyr	1348	3	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1348	4	factors	factor	NNS
cord-006860-a3b8hyyr	1348	5	could	could	MD
cord-006860-a3b8hyyr	1348	6	not	not	RB
cord-006860-a3b8hyyr	1348	7	be	be	VB
cord-006860-a3b8hyyr	1348	8	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	1348	9	.	.	.
cord-006860-a3b8hyyr	1349	1	The	the	DT
cord-006860-a3b8hyyr	1349	2	treatment	treatment	NN
cord-006860-a3b8hyyr	1349	3	of	of	IN
cord-006860-a3b8hyyr	1349	4	the	the	DT
cord-006860-a3b8hyyr	1349	5	patient	patient	NN
cord-006860-a3b8hyyr	1349	6	consisted	consist	VBD
cord-006860-a3b8hyyr	1349	7	of	of	IN
cord-006860-a3b8hyyr	1349	8	red	red	JJ
cord-006860-a3b8hyyr	1349	9	blood	blood	NN
cord-006860-a3b8hyyr	1349	10	cell	cell	NN
cord-006860-a3b8hyyr	1349	11	transfusion	transfusion	NN
cord-006860-a3b8hyyr	1349	12	and	and	CC
cord-006860-a3b8hyyr	1349	13	infusion	infusion	NN
cord-006860-a3b8hyyr	1349	14	of	of	IN
cord-006860-a3b8hyyr	1349	15	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	1349	16	complex	complex	NN
cord-006860-a3b8hyyr	1349	17	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	1349	18	.	.	.
cord-006860-a3b8hyyr	1350	1	Due	due	IN
cord-006860-a3b8hyyr	1350	2	to	to	IN
cord-006860-a3b8hyyr	1350	3	the	the	DT
cord-006860-a3b8hyyr	1350	4	extremely	extremely	RB
cord-006860-a3b8hyyr	1350	5	rapid	rapid	JJ
cord-006860-a3b8hyyr	1350	6	clearance	clearance	NN
cord-006860-a3b8hyyr	1350	7	of	of	IN
cord-006860-a3b8hyyr	1350	8	infused	infuse	VBN
cord-006860-a3b8hyyr	1350	9	factor	factor	NN
cord-006860-a3b8hyyr	1351	1	X	X	NNS
cord-006860-a3b8hyyr	1351	2	,	,	,
cord-006860-a3b8hyyr	1351	3	no	no	DT
cord-006860-a3b8hyyr	1351	4	increase	increase	NN
cord-006860-a3b8hyyr	1351	5	of	of	IN
cord-006860-a3b8hyyr	1351	6	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1351	7	activity	activity	NN
cord-006860-a3b8hyyr	1351	8	was	be	VBD
cord-006860-a3b8hyyr	1351	9	observed	observe	VBN
cord-006860-a3b8hyyr	1351	10	.	.	.
cord-006860-a3b8hyyr	1352	1	Chemotherapy	chemotherapy	NN
cord-006860-a3b8hyyr	1352	2	of	of	IN
cord-006860-a3b8hyyr	1352	3	the	the	DT
cord-006860-a3b8hyyr	1352	4	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	1352	5	gammopathy	gammopathy	NNP
cord-006860-a3b8hyyr	1352	6	was	be	VBD
cord-006860-a3b8hyyr	1352	7	initiated	initiate	VBN
cord-006860-a3b8hyyr	1352	8	(	(	-LRB-
cord-006860-a3b8hyyr	1352	9	melphalan/	melphalan/	CD
cord-006860-a3b8hyyr	1352	10	prednisone	prednisone	NNP
cord-006860-a3b8hyyr	1352	11	)	)	-RRB-
cord-006860-a3b8hyyr	1352	12	.	.	.
cord-006860-a3b8hyyr	1353	1	Over	over	IN
cord-006860-a3b8hyyr	1353	2	the	the	DT
cord-006860-a3b8hyyr	1353	3	following	follow	VBG
cord-006860-a3b8hyyr	1353	4	six	six	CD
cord-006860-a3b8hyyr	1353	5	months	month	NNS
cord-006860-a3b8hyyr	1353	6	the	the	DT
cord-006860-a3b8hyyr	1353	7	frequency	frequency	NN
cord-006860-a3b8hyyr	1353	8	of	of	IN
cord-006860-a3b8hyyr	1353	9	major	major	JJ
cord-006860-a3b8hyyr	1353	10	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1353	11	episodes	episode	NNS
cord-006860-a3b8hyyr	1353	12	gradually	gradually	RB
cord-006860-a3b8hyyr	1353	13	decreased	decrease	VBD
cord-006860-a3b8hyyr	1353	14	.	.	.
cord-006860-a3b8hyyr	1354	1	However	however	RB
cord-006860-a3b8hyyr	1354	2	,	,	,
cord-006860-a3b8hyyr	1354	3	subclinical	subclinical	JJ
cord-006860-a3b8hyyr	1354	4	occult	occult	JJ
cord-006860-a3b8hyyr	1354	5	bleeding	bleeding	NN
cord-006860-a3b8hyyr	1354	6	continued	continue	VBD
cord-006860-a3b8hyyr	1354	7	.	.	.
cord-006860-a3b8hyyr	1355	1	The	the	DT
cord-006860-a3b8hyyr	1355	2	factor	factor	NN
cord-006860-a3b8hyyr	1355	3	X	x	NN
cord-006860-a3b8hyyr	1355	4	activity	activity	NN
cord-006860-a3b8hyyr	1355	5	was	be	VBD
cord-006860-a3b8hyyr	1355	6	repeatedly	repeatedly	RB
cord-006860-a3b8hyyr	1355	7	found	find	VBN
cord-006860-a3b8hyyr	1355	8	between	between	IN
cord-006860-a3b8hyyr	1355	9	10	10	CD
cord-006860-a3b8hyyr	1355	10	and	and	CC
cord-006860-a3b8hyyr	1355	11	12	12	CD
cord-006860-a3b8hyyr	1355	12	%	%	NN
cord-006860-a3b8hyyr	1355	13	.	.	.
cord-006860-a3b8hyyr	1356	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1356	2	support	support	VBP
cord-006860-a3b8hyyr	1356	3	the	the	DT
cord-006860-a3b8hyyr	1356	4	suggestion	suggestion	NN
cord-006860-a3b8hyyr	1356	5	from	from	IN
cord-006860-a3b8hyyr	1356	6	literature	literature	NN
cord-006860-a3b8hyyr	1356	7	data	datum	NNS
cord-006860-a3b8hyyr	1356	8	that	that	WDT
cord-006860-a3b8hyyr	1356	9	clinically	clinically	RB
cord-006860-a3b8hyyr	1356	10	relevant	relevant	JJ
cord-006860-a3b8hyyr	1356	11	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	1356	12	episodes	episode	NNS
cord-006860-a3b8hyyr	1356	13	are	be	VBP
cord-006860-a3b8hyyr	1356	14	likely	likely	JJ
cord-006860-a3b8hyyr	1356	15	to	to	TO
cord-006860-a3b8hyyr	1356	16	occur	occur	VB
cord-006860-a3b8hyyr	1356	17	in	in	IN
cord-006860-a3b8hyyr	1356	18	patients	patient	NNS
cord-006860-a3b8hyyr	1356	19	with	with	IN
cord-006860-a3b8hyyr	1356	20	amyloidosis	amyloidosis	NN
cord-006860-a3b8hyyr	1356	21	-	-	HYPH
cord-006860-a3b8hyyr	1356	22	associated	associate	VBN
cord-006860-a3b8hyyr	1356	23	factor	factor	NN
cord-006860-a3b8hyyr	1356	24	X	x	NN
cord-006860-a3b8hyyr	1356	25	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1356	26	if	if	IN
cord-006860-a3b8hyyr	1356	27	the	the	DT
cord-006860-a3b8hyyr	1356	28	residual	residual	JJ
cord-006860-a3b8hyyr	1356	29	activity	activity	NN
cord-006860-a3b8hyyr	1356	30	is	be	VBZ
cord-006860-a3b8hyyr	1356	31	below	below	IN
cord-006860-a3b8hyyr	1356	32	10	10	CD
cord-006860-a3b8hyyr	1356	33	%	%	NN
cord-006860-a3b8hyyr	1356	34	.	.	.
cord-006860-a3b8hyyr	1357	1	Sepsis	sepsis	NN
cord-006860-a3b8hyyr	1357	2	and	and	CC
cord-006860-a3b8hyyr	1357	3	septic	septic	JJ
cord-006860-a3b8hyyr	1357	4	shock	shock	NN
cord-006860-a3b8hyyr	1357	5	is	be	VBZ
cord-006860-a3b8hyyr	1357	6	a	a	DT
cord-006860-a3b8hyyr	1357	7	disease	disease	NN
cord-006860-a3b8hyyr	1357	8	entity	entity	NN
cord-006860-a3b8hyyr	1357	9	which	which	WDT
cord-006860-a3b8hyyr	1357	10	is	be	VBZ
cord-006860-a3b8hyyr	1357	11	characterized	characterize	VBN
cord-006860-a3b8hyyr	1357	12	by	by	IN
cord-006860-a3b8hyyr	1357	13	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	1357	14	reactions	reaction	NNS
cord-006860-a3b8hyyr	1357	15	(	(	-LRB-
cord-006860-a3b8hyyr	1357	16	SIRS	sirs	UH
cord-006860-a3b8hyyr	1357	17	)	)	-RRB-
cord-006860-a3b8hyyr	1357	18	,	,	,
cord-006860-a3b8hyyr	1357	19	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1357	20	abnormalities	abnormality	NNS
cord-006860-a3b8hyyr	1357	21	(	(	-LRB-
cord-006860-a3b8hyyr	1357	22	DIC	DIC	NNP
cord-006860-a3b8hyyr	1357	23	)	)	-RRB-
cord-006860-a3b8hyyr	1357	24	,	,	,
cord-006860-a3b8hyyr	1357	25	organ	organ	NN
cord-006860-a3b8hyyr	1357	26	failure	failure	NN
cord-006860-a3b8hyyr	1357	27	(	(	-LRB-
cord-006860-a3b8hyyr	1357	28	MOF	MOF	NNP
cord-006860-a3b8hyyr	1357	29	)	)	-RRB-
cord-006860-a3b8hyyr	1357	30	and	and	CC
cord-006860-a3b8hyyr	1357	31	severe	severe	JJ
cord-006860-a3b8hyyr	1357	32	hemodynamic	hemodynamic	JJ
cord-006860-a3b8hyyr	1357	33	alteration	alteration	NN
cord-006860-a3b8hyyr	1357	34	frequently	frequently	RB
cord-006860-a3b8hyyr	1357	35	leading	lead	VBG
cord-006860-a3b8hyyr	1357	36	to	to	IN
cord-006860-a3b8hyyr	1357	37	death	death	NN
cord-006860-a3b8hyyr	1357	38	in	in	IN
cord-006860-a3b8hyyr	1357	39	a	a	DT
cord-006860-a3b8hyyr	1357	40	shock	shock	NN
cord-006860-a3b8hyyr	1357	41	.	.	.
cord-006860-a3b8hyyr	1358	1	The	the	DT
cord-006860-a3b8hyyr	1358	2	aim	aim	NN
cord-006860-a3b8hyyr	1358	3	of	of	IN
cord-006860-a3b8hyyr	1358	4	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1358	5	studies	study	NNS
cord-006860-a3b8hyyr	1358	6	was	be	VBD
cord-006860-a3b8hyyr	1358	7	to	to	TO
cord-006860-a3b8hyyr	1358	8	investigate	investigate	VB
cord-006860-a3b8hyyr	1358	9	the	the	DT
cord-006860-a3b8hyyr	1358	10	efficacy	efficacy	NN
cord-006860-a3b8hyyr	1358	11	of	of	IN
cord-006860-a3b8hyyr	1358	12	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	1358	13	III	III	NNP
cord-006860-a3b8hyyr	1358	14	(	(	-LRB-
cord-006860-a3b8hyyr	1358	15	Kybernin	Kybernin	NNP
cord-006860-a3b8hyyr	1358	16	®	®	POS
cord-006860-a3b8hyyr	1358	17	)	)	-RRB-
cord-006860-a3b8hyyr	1358	18	on	on	IN
cord-006860-a3b8hyyr	1358	19	~he	~he	NNP
cord-006860-a3b8hyyr	1358	20	outcome	outcome	NN
cord-006860-a3b8hyyr	1358	21	of	of	IN
cord-006860-a3b8hyyr	1358	22	septic	septic	JJ
cord-006860-a3b8hyyr	1358	23	shock	shock	NN
cord-006860-a3b8hyyr	1358	24	in	in	IN
cord-006860-a3b8hyyr	1358	25	a	a	DT
cord-006860-a3b8hyyr	1358	26	pig	pig	NN
cord-006860-a3b8hyyr	1358	27	endotoxemic	endotoxemic	NNP
cord-006860-a3b8hyyr	1358	28	model	model	NN
cord-006860-a3b8hyyr	1358	29	.	.	.
cord-006860-a3b8hyyr	1359	1	Pigs	pig	NNS
cord-006860-a3b8hyyr	1359	2	,	,	,
cord-006860-a3b8hyyr	1359	3	in	in	IN
cord-006860-a3b8hyyr	1359	4	this	this	DT
cord-006860-a3b8hyyr	1359	5	model	model	NN
cord-006860-a3b8hyyr	1359	6	respond	respond	VBZ
cord-006860-a3b8hyyr	1359	7	to	to	IN
cord-006860-a3b8hyyr	1359	8	LPS	LPS	NNP
cord-006860-a3b8hyyr	1359	9	with	with	IN
cord-006860-a3b8hyyr	1359	10	elevated	elevated	JJ
cord-006860-a3b8hyyr	1359	11	TNFlevels	tnflevel	NNS
cord-006860-a3b8hyyr	1359	12	,	,	,
cord-006860-a3b8hyyr	1359	13	decreased	decreased	JJ
cord-006860-a3b8hyyr	1359	14	leukocytes	leukocyte	NNS
cord-006860-a3b8hyyr	1359	15	and	and	CC
cord-006860-a3b8hyyr	1359	16	platelets	platelet	NNS
cord-006860-a3b8hyyr	1359	17	counts	count	NNS
cord-006860-a3b8hyyr	1359	18	,	,	,
cord-006860-a3b8hyyr	1359	19	increased	increase	VBD
cord-006860-a3b8hyyr	1359	20	TAT	tat	NN
cord-006860-a3b8hyyr	1359	21	and	and	CC
cord-006860-a3b8hyyr	1359	22	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1359	23	monomer	monomer	NN
cord-006860-a3b8hyyr	1359	24	levels	level	NNS
cord-006860-a3b8hyyr	1359	25	,	,	,
cord-006860-a3b8hyyr	1359	26	hypotension	hypotension	NN
cord-006860-a3b8hyyr	1359	27	and	and	CC
cord-006860-a3b8hyyr	1359	28	in	in	IN
cord-006860-a3b8hyyr	1359	29	increase	increase	NN
cord-006860-a3b8hyyr	1359	30	of	of	IN
cord-006860-a3b8hyyr	1359	31	the	the	DT
cord-006860-a3b8hyyr	1359	32	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	1359	33	arterial	arterial	JJ
cord-006860-a3b8hyyr	1359	34	pressure	pressure	NN
cord-006860-a3b8hyyr	1359	35	(	(	-LRB-
cord-006860-a3b8hyyr	1359	36	PAP	pap	NN
cord-006860-a3b8hyyr	1359	37	)	)	-RRB-
cord-006860-a3b8hyyr	1359	38	,	,	,
cord-006860-a3b8hyyr	1359	39	indicating	indicate	VBG
cord-006860-a3b8hyyr	1359	40	impaired	impair	VBN
cord-006860-a3b8hyyr	1359	41	lung	lung	NN
cord-006860-a3b8hyyr	1359	42	function	function	NN
cord-006860-a3b8hyyr	1359	43	.	.	.
cord-006860-a3b8hyyr	1360	1	A	a	DT
cord-006860-a3b8hyyr	1360	2	total	total	JJ
cord-006860-a3b8hyyr	1360	3	number	number	NN
cord-006860-a3b8hyyr	1360	4	of	of	IN
cord-006860-a3b8hyyr	1360	5	13	13	CD
cord-006860-a3b8hyyr	1360	6	male	male	JJ
cord-006860-a3b8hyyr	1360	7	castrated	castrate	VBN
cord-006860-a3b8hyyr	1360	8	juvenile	juvenile	JJ
cord-006860-a3b8hyyr	1360	9	domestic	domestic	JJ
cord-006860-a3b8hyyr	1360	10	pigs	pig	NNS
cord-006860-a3b8hyyr	1360	11	(	(	-LRB-
cord-006860-a3b8hyyr	1360	12	25	25	CD
cord-006860-a3b8hyyr	1360	13	-30	-30	SYM
cord-006860-a3b8hyyr	1360	14	kg	kg	NN
cord-006860-a3b8hyyr	1360	15	)	)	-RRB-
cord-006860-a3b8hyyr	1360	16	were	be	VBD
cord-006860-a3b8hyyr	1360	17	anaesthetized	anaesthetize	VBN
cord-006860-a3b8hyyr	1360	18	,	,	,
cord-006860-a3b8hyyr	1360	19	ventilated	ventilate	VBN
cord-006860-a3b8hyyr	1360	20	mechanically	mechanically	RB
cord-006860-a3b8hyyr	1360	21	and	and	CC
cord-006860-a3b8hyyr	1360	22	infused	infuse	VBN
cord-006860-a3b8hyyr	1360	23	with	with	IN
cord-006860-a3b8hyyr	1360	24	Saimonella	Saimonella	NNP
cord-006860-a3b8hyyr	1360	25	abortus	abortus	NN
cord-006860-a3b8hyyr	1360	26	equi	equi	NN
cord-006860-a3b8hyyr	1360	27	lipopolysaccharide	lipopolysaccharide	NN
cord-006860-a3b8hyyr	1360	28	(	(	-LRB-
cord-006860-a3b8hyyr	1360	29	S.	S.	NNP
cord-006860-a3b8hyyr	1360	30	equ	equ	NN
cord-006860-a3b8hyyr	1360	31	-	-	HYPH
cord-006860-a3b8hyyr	1360	32	LPS	LPS	NNP
cord-006860-a3b8hyyr	1360	33	)	)	-RRB-
cord-006860-a3b8hyyr	1360	34	over	over	IN
cord-006860-a3b8hyyr	1360	35	three	three	CD
cord-006860-a3b8hyyr	1360	36	hours	hour	NNS
cord-006860-a3b8hyyr	1360	37	(	(	-LRB-
cord-006860-a3b8hyyr	1360	38	0.5	0.5	CD
cord-006860-a3b8hyyr	1360	39	~g	~g	NNP
cord-006860-a3b8hyyr	1360	40	/	/	SYM
cord-006860-a3b8hyyr	1360	41	kg	kg	NN
cord-006860-a3b8hyyr	1360	42	*	*	NFP
cord-006860-a3b8hyyr	1360	43	h	h	NN
cord-006860-a3b8hyyr	1360	44	)	)	-RRB-
cord-006860-a3b8hyyr	1360	45	.	.	.
cord-006860-a3b8hyyr	1361	1	A	a	DT
cord-006860-a3b8hyyr	1361	2	Swan	Swan	NNP
cord-006860-a3b8hyyr	1361	3	-	-	HYPH
cord-006860-a3b8hyyr	1361	4	Ganz	Ganz	NNP
cord-006860-a3b8hyyr	1361	5	-	-	HYPH
cord-006860-a3b8hyyr	1361	6	Catheter	Catheter	NNP
cord-006860-a3b8hyyr	1361	7	was	be	VBD
cord-006860-a3b8hyyr	1361	8	inserted	insert	VBN
cord-006860-a3b8hyyr	1361	9	into	into	IN
cord-006860-a3b8hyyr	1361	10	the	the	DT
cord-006860-a3b8hyyr	1361	11	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	1361	12	artery	artery	NN
cord-006860-a3b8hyyr	1361	13	to	to	TO
cord-006860-a3b8hyyr	1361	14	measure	measure	VB
cord-006860-a3b8hyyr	1361	15	the	the	DT
cord-006860-a3b8hyyr	1361	16	PAP	pap	NN
cord-006860-a3b8hyyr	1361	17	.	.	.
cord-006860-a3b8hyyr	1362	1	Animals	animal	NNS
cord-006860-a3b8hyyr	1362	2	were	be	VBD
cord-006860-a3b8hyyr	1362	3	allocated	allocate	VBN
cord-006860-a3b8hyyr	1362	4	to	to	IN
cord-006860-a3b8hyyr	1362	5	two	two	CD
cord-006860-a3b8hyyr	1362	6	groups	group	NNS
cord-006860-a3b8hyyr	1362	7	,	,	,
cord-006860-a3b8hyyr	1362	8	,	,	,
cord-006860-a3b8hyyr	1362	9	the	the	DT
cord-006860-a3b8hyyr	1362	10	treatment	treatment	NN
cord-006860-a3b8hyyr	1362	11	group	group	NN
cord-006860-a3b8hyyr	1362	12	(	(	-LRB-
cord-006860-a3b8hyyr	1362	13	n	n	NN
cord-006860-a3b8hyyr	1362	14	=	=	SYM
cord-006860-a3b8hyyr	1362	15	7	7	CD
cord-006860-a3b8hyyr	1362	16	)	)	-RRB-
cord-006860-a3b8hyyr	1362	17	received	receive	VBD
cord-006860-a3b8hyyr	1362	18	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	1362	19	III	III	NNP
cord-006860-a3b8hyyr	1362	20	(	(	-LRB-
cord-006860-a3b8hyyr	1362	21	AT	at	IN
cord-006860-a3b8hyyr	1362	22	III	III	NNP
cord-006860-a3b8hyyr	1362	23	)	)	-RRB-
cord-006860-a3b8hyyr	1362	24	according	accord	VBG
cord-006860-a3b8hyyr	1362	25	to	to	IN
cord-006860-a3b8hyyr	1362	26	the	the	DT
cord-006860-a3b8hyyr	1362	27	following	follow	VBG
cord-006860-a3b8hyyr	1362	28	regimen	regimen	NN
cord-006860-a3b8hyyr	1362	29	:	:	:
cord-006860-a3b8hyyr	1363	1	250	250	CD
cord-006860-a3b8hyyr	1363	2	U	u	NN
cord-006860-a3b8hyyr	1363	3	/	/	SYM
cord-006860-a3b8hyyr	1363	4	kg	kg	NN
cord-006860-a3b8hyyr	1364	1	(	(	-LRB-
cord-006860-a3b8hyyr	1364	2	t	t	NN
cord-006860-a3b8hyyr	1364	3	=	=	SYM
cord-006860-a3b8hyyr	1364	4	60	60	CD
cord-006860-a3b8hyyr	1364	5	-30	-30	NN
cord-006860-a3b8hyyr	1364	6	,	,	,
cord-006860-a3b8hyyr	1364	7	i.	i.	NN
cord-006860-a3b8hyyr	1364	8	v.	v.	CC
cord-006860-a3b8hyyr	1364	9	infusion	infusion	NN
cord-006860-a3b8hyyr	1364	10	)	)	-RRB-
cord-006860-a3b8hyyr	1364	11	,	,	,
cord-006860-a3b8hyyr	1364	12	125	125	CD
cord-006860-a3b8hyyr	1364	13	U	u	NN
cord-006860-a3b8hyyr	1364	14	/	/	SYM
cord-006860-a3b8hyyr	1364	15	kg	kg	NN
cord-006860-a3b8hyyr	1365	1	(	(	-LRB-
cord-006860-a3b8hyyr	1365	2	i.	i.	NN
cord-006860-a3b8hyyr	1365	3	v.	v.	CC
cord-006860-a3b8hyyr	1365	4	bolus	bolus	NNP
cord-006860-a3b8hyyr	1365	5	,	,	,
cord-006860-a3b8hyyr	1365	6	t	t	NN
cord-006860-a3b8hyyr	1365	7	=	=	SYM
cord-006860-a3b8hyyr	1365	8	0	0	CD
cord-006860-a3b8hyyr	1365	9	)	)	-RRB-
cord-006860-a3b8hyyr	1365	10	and	and	CC
cord-006860-a3b8hyyr	1365	11	250	250	CD
cord-006860-a3b8hyyr	1365	12	U	u	NN
cord-006860-a3b8hyyr	1365	13	/	/	SYM
cord-006860-a3b8hyyr	1365	14	kg	kg	NN
cord-006860-a3b8hyyr	1366	1	(	(	-LRB-
cord-006860-a3b8hyyr	1366	2	t	t	NN
cord-006860-a3b8hyyr	1366	3	=	=	SYM
cord-006860-a3b8hyyr	1366	4	180	180	CD
cord-006860-a3b8hyyr	1366	5	-240	-240	NNS
cord-006860-a3b8hyyr	1366	6	rain	rain	NN
cord-006860-a3b8hyyr	1366	7	,	,	,
cord-006860-a3b8hyyr	1366	8	i.	i.	NN
cord-006860-a3b8hyyr	1366	9	v.	v.	CC
cord-006860-a3b8hyyr	1366	10	infusion	infusion	NN
cord-006860-a3b8hyyr	1366	11	)	)	-RRB-
cord-006860-a3b8hyyr	1366	12	.	.	.
cord-006860-a3b8hyyr	1367	1	The	the	DT
cord-006860-a3b8hyyr	1367	2	placebo	placebo	NN
cord-006860-a3b8hyyr	1367	3	group	group	NN
cord-006860-a3b8hyyr	1367	4	(	(	-LRB-
cord-006860-a3b8hyyr	1367	5	n	n	NN
cord-006860-a3b8hyyr	1367	6	=	=	SYM
cord-006860-a3b8hyyr	1367	7	6	6	CD
cord-006860-a3b8hyyr	1367	8	)	)	-RRB-
cord-006860-a3b8hyyr	1367	9	received	receive	VBD
cord-006860-a3b8hyyr	1367	10	the	the	DT
cord-006860-a3b8hyyr	1367	11	appropriate	appropriate	JJ
cord-006860-a3b8hyyr	1367	12	amount	amount	NN
cord-006860-a3b8hyyr	1367	13	of	of	IN
cord-006860-a3b8hyyr	1367	14	human	human	JJ
cord-006860-a3b8hyyr	1367	15	serum	serum	NN
cord-006860-a3b8hyyr	1367	16	albumin	albumin	NN
cord-006860-a3b8hyyr	1367	17	:	:	:
cord-006860-a3b8hyyr	1367	18	50	50	CD
cord-006860-a3b8hyyr	1367	19	-25	-25	NN
cord-006860-a3b8hyyr	1367	20	-50	-50	NNP
cord-006860-a3b8hyyr	1367	21	mg	mg	NNP
cord-006860-a3b8hyyr	1367	22	/	/	SYM
cord-006860-a3b8hyyr	1367	23	kg	kg	NNP
cord-006860-a3b8hyyr	1367	24	(	(	-LRB-
cord-006860-a3b8hyyr	1367	25	same	same	JJ
cord-006860-a3b8hyyr	1367	26	schedule	schedule	NN
cord-006860-a3b8hyyr	1367	27	as	as	IN
cord-006860-a3b8hyyr	1367	28	with	with	IN
cord-006860-a3b8hyyr	1367	29	AT	AT	NNP
cord-006860-a3b8hyyr	1367	30	III	III	NNP
cord-006860-a3b8hyyr	1367	31	)	)	-RRB-
cord-006860-a3b8hyyr	1367	32	.	.	.
cord-006860-a3b8hyyr	1368	1	Main	main	JJ
cord-006860-a3b8hyyr	1368	2	objective	objective	NN
cord-006860-a3b8hyyr	1368	3	was	be	VBD
cord-006860-a3b8hyyr	1368	4	defined	define	VBN
cord-006860-a3b8hyyr	1368	5	as	as	IN
cord-006860-a3b8hyyr	1368	6	the	the	DT
cord-006860-a3b8hyyr	1368	7	mortality	mortality	NN
cord-006860-a3b8hyyr	1368	8	rate	rate	NN
cord-006860-a3b8hyyr	1368	9	at	at	IN
cord-006860-a3b8hyyr	1368	10	six	six	CD
cord-006860-a3b8hyyr	1368	11	hours	hour	NNS
cord-006860-a3b8hyyr	1369	1	a_~er	a_~er	NNP
cord-006860-a3b8hyyr	1369	2	S.	S.	NNP
cord-006860-a3b8hyyr	1369	3	equ	equ	NN
cord-006860-a3b8hyyr	1369	4	-	-	HYPH
cord-006860-a3b8hyyr	1369	5	LPS	lps	NN
cord-006860-a3b8hyyr	1369	6	infusion	infusion	NN
cord-006860-a3b8hyyr	1369	7	.	.	.
cord-006860-a3b8hyyr	1370	1	Whereas	whereas	IN
cord-006860-a3b8hyyr	1370	2	in	in	IN
cord-006860-a3b8hyyr	1370	3	the	the	DT
cord-006860-a3b8hyyr	1370	4	placebo	placebo	NN
cord-006860-a3b8hyyr	1370	5	group	group	NN
cord-006860-a3b8hyyr	1370	6	4	4	CD
cord-006860-a3b8hyyr	1370	7	out	out	IN
cord-006860-a3b8hyyr	1370	8	of	of	IN
cord-006860-a3b8hyyr	1370	9	6	6	CD
cord-006860-a3b8hyyr	1370	10	animal	animal	NN
cord-006860-a3b8hyyr	1370	11	died	die	VBD
cord-006860-a3b8hyyr	1370	12	(	(	-LRB-
cord-006860-a3b8hyyr	1370	13	mortality	mortality	NN
cord-006860-a3b8hyyr	1370	14	rate	rate	NN
cord-006860-a3b8hyyr	1370	15	:	:	:
cord-006860-a3b8hyyr	1370	16	66	66	CD
cord-006860-a3b8hyyr	1370	17	%	%	NN
cord-006860-a3b8hyyr	1370	18	)	)	-RRB-
cord-006860-a3b8hyyr	1370	19	all	all	DT
cord-006860-a3b8hyyr	1370	20	AT	at	IN
cord-006860-a3b8hyyr	1370	21	III	III	NNP
cord-006860-a3b8hyyr	1370	22	-	-	HYPH
cord-006860-a3b8hyyr	1370	23	treated	treat	VBN
cord-006860-a3b8hyyr	1370	24	pigs	pig	NNS
cord-006860-a3b8hyyr	1370	25	survived	survive	VBD
cord-006860-a3b8hyyr	1370	26	the	the	DT
cord-006860-a3b8hyyr	1370	27	observation	observation	NN
cord-006860-a3b8hyyr	1370	28	period	period	NN
cord-006860-a3b8hyyr	1370	29	of	of	IN
cord-006860-a3b8hyyr	1370	30	6	6	CD
cord-006860-a3b8hyyr	1370	31	hours	hour	NNS
cord-006860-a3b8hyyr	1370	32	(	(	-LRB-
cord-006860-a3b8hyyr	1370	33	p	p	NN
cord-006860-a3b8hyyr	1370	34	<	<	XX
cord-006860-a3b8hyyr	1370	35	0.05	0.05	CD
cord-006860-a3b8hyyr	1370	36	,	,	,
cord-006860-a3b8hyyr	1370	37	X2-test	X2-test	NNP
cord-006860-a3b8hyyr	1370	38	)	)	-RRB-
cord-006860-a3b8hyyr	1370	39	.	.	.
cord-006860-a3b8hyyr	1371	1	The	the	DT
cord-006860-a3b8hyyr	1371	2	AT	AT	NNP
cord-006860-a3b8hyyr	1371	3	III	III	NNP
cord-006860-a3b8hyyr	1371	4	group	group	NN
cord-006860-a3b8hyyr	1371	5	was	be	VBD
cord-006860-a3b8hyyr	1371	6	shown	show	VBN
cord-006860-a3b8hyyr	1371	7	to	to	TO
cord-006860-a3b8hyyr	1371	8	have	have	VB
cord-006860-a3b8hyyr	1371	9	a	a	DT
cord-006860-a3b8hyyr	1371	10	lower	low	JJR
cord-006860-a3b8hyyr	1371	11	PAP	pap	NN
cord-006860-a3b8hyyr	1371	12	than	than	IN
cord-006860-a3b8hyyr	1371	13	the	the	DT
cord-006860-a3b8hyyr	1371	14	control	control	NN
cord-006860-a3b8hyyr	1371	15	group	group	NN
cord-006860-a3b8hyyr	1371	16	,	,	,
cord-006860-a3b8hyyr	1371	17	especially	especially	RB
cord-006860-a3b8hyyr	1371	18	the	the	DT
cord-006860-a3b8hyyr	1371	19	second	second	JJ
cord-006860-a3b8hyyr	1371	20	peak	peak	NN
cord-006860-a3b8hyyr	1371	21	of	of	IN
cord-006860-a3b8hyyr	1371	22	hypertension	hypertension	NN
cord-006860-a3b8hyyr	1371	23	was	be	VBD
cord-006860-a3b8hyyr	1371	24	abolished	abolish	VBN
cord-006860-a3b8hyyr	1371	25	by	by	IN
cord-006860-a3b8hyyr	1371	26	AT	AT	NNP
cord-006860-a3b8hyyr	1371	27	III	III	NNP
cord-006860-a3b8hyyr	1371	28	.	.	.
cord-006860-a3b8hyyr	1372	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1372	2	is	be	VBZ
cord-006860-a3b8hyyr	1372	3	therefore	therefore	RB
cord-006860-a3b8hyyr	1372	4	concluded	conclude	VBN
cord-006860-a3b8hyyr	1372	5	that	that	IN
cord-006860-a3b8hyyr	1372	6	AT	AT	NNP
cord-006860-a3b8hyyr	1372	7	III	III	NNP
cord-006860-a3b8hyyr	1372	8	should	should	MD
cord-006860-a3b8hyyr	1372	9	be	be	VB
cord-006860-a3b8hyyr	1372	10	a	a	DT
cord-006860-a3b8hyyr	1372	11	useful	useful	JJ
cord-006860-a3b8hyyr	1372	12	tool	tool	NN
cord-006860-a3b8hyyr	1372	13	for	for	IN
cord-006860-a3b8hyyr	1372	14	the	the	DT
cord-006860-a3b8hyyr	1372	15	treatment	treatment	NN
cord-006860-a3b8hyyr	1372	16	of	of	IN
cord-006860-a3b8hyyr	1372	17	severe	severe	JJ
cord-006860-a3b8hyyr	1372	18	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1372	19	and	and	CC
cord-006860-a3b8hyyr	1372	20	septic	septic	JJ
cord-006860-a3b8hyyr	1372	21	shock	shock	NN
cord-006860-a3b8hyyr	1372	22	.	.	.
cord-006860-a3b8hyyr	1373	1	In	in	IN
cord-006860-a3b8hyyr	1373	2	a	a	DT
cord-006860-a3b8hyyr	1373	3	nationwide	nationwide	JJ
cord-006860-a3b8hyyr	1373	4	monthly	monthly	JJ
cord-006860-a3b8hyyr	1373	5	survey	survey	NN
cord-006860-a3b8hyyr	1373	6	all	all	DT
cord-006860-a3b8hyyr	1373	7	childrens	children	NNS
cord-006860-a3b8hyyr	1373	8	hospitals	hospital	NNS
cord-006860-a3b8hyyr	1373	9	in	in	IN
cord-006860-a3b8hyyr	1373	10	Germany	Germany	NNP
cord-006860-a3b8hyyr	1373	11	(	(	-LRB-
cord-006860-a3b8hyyr	1373	12	ESPED	ESPED	NNP
cord-006860-a3b8hyyr	1373	13	)	)	-RRB-
cord-006860-a3b8hyyr	1373	14	were	be	VBD
cord-006860-a3b8hyyr	1373	15	asked	ask	VBN
cord-006860-a3b8hyyr	1373	16	to	to	IN
cord-006860-a3b8hyyr	1373	17	clinical	clinical	JJ
cord-006860-a3b8hyyr	1373	18	and	and	CC
cord-006860-a3b8hyyr	1373	19	therapeutical	therapeutical	JJ
cord-006860-a3b8hyyr	1373	20	informations	information	NNS
cord-006860-a3b8hyyr	1373	21	about	about	IN
cord-006860-a3b8hyyr	1373	22	children	child	NNS
cord-006860-a3b8hyyr	1373	23	suffering	suffer	VBG
cord-006860-a3b8hyyr	1373	24	from	from	IN
cord-006860-a3b8hyyr	1373	25	PMI	PMI	NNP
cord-006860-a3b8hyyr	1373	26	.	.	.
cord-006860-a3b8hyyr	1374	1	During	during	IN
cord-006860-a3b8hyyr	1374	2	July	July	NNP
cord-006860-a3b8hyyr	1374	3	94	94	CD
cord-006860-a3b8hyyr	1374	4	till	till	IN
cord-006860-a3b8hyyr	1374	5	June	June	NNP
cord-006860-a3b8hyyr	1374	6	95	95	CD
cord-006860-a3b8hyyr	1374	7	299	299	CD
cord-006860-a3b8hyyr	1374	8	children	child	NNS
cord-006860-a3b8hyyr	1374	9	were	be	VBD
cord-006860-a3b8hyyr	1374	10	registered	register	VBN
cord-006860-a3b8hyyr	1374	11	.	.	.
cord-006860-a3b8hyyr	1375	1	From	from	IN
cord-006860-a3b8hyyr	1375	2	these	these	DT
cord-006860-a3b8hyyr	1375	3	,	,	,
cord-006860-a3b8hyyr	1375	4	87	87	CD
cord-006860-a3b8hyyr	1375	5	had	have	VBD
cord-006860-a3b8hyyr	1375	6	either	either	CC
cord-006860-a3b8hyyr	1375	7	ecchymoses	ecchymosis	NNS
cord-006860-a3b8hyyr	1375	8	and/or	and/or	CC
cord-006860-a3b8hyyr	1375	9	necroses	necroses	NNP
cord-006860-a3b8hyyr	1375	10	related	relate	VBN
cord-006860-a3b8hyyr	1375	11	to	to	IN
cord-006860-a3b8hyyr	1375	12	an	an	DT
cord-006860-a3b8hyyr	1375	13	increased	increase	VBN
cord-006860-a3b8hyyr	1375	14	mordibity	mordibity	NN
cord-006860-a3b8hyyr	1375	15	and	and	CC
cord-006860-a3b8hyyr	1375	16	mortality	mortality	NN
cord-006860-a3b8hyyr	1375	17	(	(	-LRB-
cord-006860-a3b8hyyr	1375	18	20	20	CD
cord-006860-a3b8hyyr	1375	19	%	%	NN
cord-006860-a3b8hyyr	1375	20	)	)	-RRB-
cord-006860-a3b8hyyr	1375	21	,	,	,
cord-006860-a3b8hyyr	1375	22	whereas	whereas	IN
cord-006860-a3b8hyyr	1375	23	212	212	CD
cord-006860-a3b8hyyr	1375	24	showed	show	VBD
cord-006860-a3b8hyyr	1375	25	no	no	DT
cord-006860-a3b8hyyr	1375	26	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1375	27	signs	sign	NNS
cord-006860-a3b8hyyr	1375	28	except	except	IN
cord-006860-a3b8hyyr	1375	29	for	for	IN
cord-006860-a3b8hyyr	1375	30	petechiae	petechia	NNS
cord-006860-a3b8hyyr	1375	31	.	.	.
cord-006860-a3b8hyyr	1376	1	Of	of	IN
cord-006860-a3b8hyyr	1376	2	these	these	DT
cord-006860-a3b8hyyr	1376	3	children	child	NNS
cord-006860-a3b8hyyr	1376	4	one	one	CD
cord-006860-a3b8hyyr	1376	5	died	die	VBD
cord-006860-a3b8hyyr	1376	6	.	.	.
cord-006860-a3b8hyyr	1377	1	The	the	DT
cord-006860-a3b8hyyr	1377	2	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	1377	3	interventions	intervention	NNS
cord-006860-a3b8hyyr	1377	4	concerning	concern	VBG
cord-006860-a3b8hyyr	1377	5	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	1377	6	are	be	VBP
cord-006860-a3b8hyyr	1377	7	listed	list	VBN
cord-006860-a3b8hyyr	1377	8	according	accord	VBG
cord-006860-a3b8hyyr	1377	9	to	to	IN
cord-006860-a3b8hyyr	1377	10	the	the	DT
cord-006860-a3b8hyyr	1377	11	defined	define	VBN
cord-006860-a3b8hyyr	1377	12	two	two	CD
cord-006860-a3b8hyyr	1377	13	risk	risk	NN
cord-006860-a3b8hyyr	1377	14	~oups	~oups	NNP
cord-006860-a3b8hyyr	1377	15	.	.	.
cord-006860-a3b8hyyr	1378	1	From	from	IN
cord-006860-a3b8hyyr	1378	2	the	the	DT
cord-006860-a3b8hyyr	1378	3	patients	patient	NNS
cord-006860-a3b8hyyr	1378	4	with	with	IN
cord-006860-a3b8hyyr	1378	5	ecchymoses	ecchymosis	NNS
cord-006860-a3b8hyyr	1378	6	or	or	CC
cord-006860-a3b8hyyr	1378	7	necroses	necroses	NNP
cord-006860-a3b8hyyr	1378	8	,	,	,
cord-006860-a3b8hyyr	1378	9	13/87	13/87	CD
cord-006860-a3b8hyyr	1378	10	received	receive	VBD
cord-006860-a3b8hyyr	1378	11	combination	combination	NN
cord-006860-a3b8hyyr	1378	12	therapy	therapy	NN
cord-006860-a3b8hyyr	1378	13	(	(	-LRB-
cord-006860-a3b8hyyr	1378	14	compared	compare	VBN
cord-006860-a3b8hyyr	1378	15	to	to	IN
cord-006860-a3b8hyyr	1378	16	5/212	5/212	CD
cord-006860-a3b8hyyr	1378	17	with	with	IN
cord-006860-a3b8hyyr	1378	18	petechiae	petechia	NNS
cord-006860-a3b8hyyr	1378	19	or	or	CC
cord-006860-a3b8hyyr	1378	20	no	no	DT
cord-006860-a3b8hyyr	1378	21	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1378	22	sign	sign	NN
cord-006860-a3b8hyyr	1378	23	)	)	-RRB-
cord-006860-a3b8hyyr	1378	24	of	of	IN
cord-006860-a3b8hyyr	1378	25	AT	AT	NNP
cord-006860-a3b8hyyr	1378	26	III	III	NNP
cord-006860-a3b8hyyr	1378	27	,	,	,
cord-006860-a3b8hyyr	1378	28	heparin	heparin	NN
cord-006860-a3b8hyyr	1378	29	and/or	and/or	CC
cord-006860-a3b8hyyr	1378	30	plasma	plasma	NN
cord-006860-a3b8hyyr	1378	31	.	.	.
cord-006860-a3b8hyyr	1379	1	Only	only	RB
cord-006860-a3b8hyyr	1379	2	t	t	NN
cord-006860-a3b8hyyr	1379	3	child	child	NN
cord-006860-a3b8hyyr	1379	4	received	receive	VBD
cord-006860-a3b8hyyr	1379	5	protein	protein	NN
cord-006860-a3b8hyyr	1379	6	C	C	NNP
cord-006860-a3b8hyyr	1379	7	concentrate	concentrate	NN
cord-006860-a3b8hyyr	1379	8	.	.	.
cord-006860-a3b8hyyr	1380	1	The	the	DT
cord-006860-a3b8hyyr	1380	2	data	datum	NNS
cord-006860-a3b8hyyr	1380	3	show	show	VBP
cord-006860-a3b8hyyr	1380	4	that	that	IN
cord-006860-a3b8hyyr	1380	5	children	child	NNS
cord-006860-a3b8hyyr	1380	6	with	with	IN
cord-006860-a3b8hyyr	1380	7	low	low	JJ
cord-006860-a3b8hyyr	1380	8	risk	risk	NN
cord-006860-a3b8hyyr	1380	9	did	do	VBD
cord-006860-a3b8hyyr	1380	10	in	in	IN
cord-006860-a3b8hyyr	1380	11	part	part	NN
cord-006860-a3b8hyyr	1380	12	receive	receive	VB
cord-006860-a3b8hyyr	1380	13	higher	high	JJR
cord-006860-a3b8hyyr	1380	14	doses	dose	NNS
cord-006860-a3b8hyyr	1380	15	of	of	IN
cord-006860-a3b8hyyr	1380	16	heparin	heparin	NN
cord-006860-a3b8hyyr	1381	1	and/or	and/or	CC
cord-006860-a3b8hyyr	1382	1	AT	at	IN
cord-006860-a3b8hyyr	1382	2	III	iii	CD
cord-006860-a3b8hyyr	1382	3	concentrate	concentrate	NN
cord-006860-a3b8hyyr	1382	4	than	than	IN
cord-006860-a3b8hyyr	1382	5	did	do	VBD
cord-006860-a3b8hyyr	1382	6	high	high	JJ
cord-006860-a3b8hyyr	1382	7	risk	risk	NN
cord-006860-a3b8hyyr	1382	8	patients	patient	NNS
cord-006860-a3b8hyyr	1382	9	,	,	,
cord-006860-a3b8hyyr	1382	10	whereas	whereas	IN
cord-006860-a3b8hyyr	1382	11	plasma	plasma	NN
cord-006860-a3b8hyyr	1382	12	therapy	therapy	NN
cord-006860-a3b8hyyr	1382	13	was	be	VBD
cord-006860-a3b8hyyr	1382	14	adjusted	adjust	VBN
cord-006860-a3b8hyyr	1382	15	to	to	IN
cord-006860-a3b8hyyr	1382	16	severity	severity	NN
cord-006860-a3b8hyyr	1382	17	of	of	IN
cord-006860-a3b8hyyr	1382	18	eoagnlopathy	eoagnlopathy	NNP
cord-006860-a3b8hyyr	1382	19	.	.	.
cord-006860-a3b8hyyr	1383	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	1383	2	,	,	,
cord-006860-a3b8hyyr	1383	3	the	the	DT
cord-006860-a3b8hyyr	1383	4	wide	wide	JJ
cord-006860-a3b8hyyr	1383	5	range	range	NN
cord-006860-a3b8hyyr	1383	6	of	of	IN
cord-006860-a3b8hyyr	1383	7	given	give	VBN
cord-006860-a3b8hyyr	1383	8	therapeutics	therapeutic	NNS
cord-006860-a3b8hyyr	1383	9	allows	allow	VBZ
cord-006860-a3b8hyyr	1383	10	no	no	DT
cord-006860-a3b8hyyr	1383	11	information	information	NN
cord-006860-a3b8hyyr	1383	12	about	about	IN
cord-006860-a3b8hyyr	1383	13	the	the	DT
cord-006860-a3b8hyyr	1383	14	different	different	JJ
cord-006860-a3b8hyyr	1383	15	medications	medication	NNS
cord-006860-a3b8hyyr	1383	16	.	.	.
cord-006860-a3b8hyyr	1384	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	1384	2	,	,	,
cord-006860-a3b8hyyr	1384	3	controlled	control	VBN
cord-006860-a3b8hyyr	1384	4	studies	study	NNS
cord-006860-a3b8hyyr	1384	5	with	with	IN
cord-006860-a3b8hyyr	1384	6	respect	respect	NN
cord-006860-a3b8hyyr	1384	7	to	to	IN
cord-006860-a3b8hyyr	1384	8	the	the	DT
cord-006860-a3b8hyyr	1384	9	different	different	JJ
cord-006860-a3b8hyyr	1384	10	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	1384	11	interventions	intervention	NNS
cord-006860-a3b8hyyr	1384	12	in	in	IN
cord-006860-a3b8hyyr	1384	13	children	child	NNS
cord-006860-a3b8hyyr	1384	14	with	with	IN
cord-006860-a3b8hyyr	1384	15	high	high	JJ
cord-006860-a3b8hyyr	1384	16	risk	risk	NN
cord-006860-a3b8hyyr	1384	17	PMI	PMI	NNP
cord-006860-a3b8hyyr	1384	18	is	be	VBZ
cord-006860-a3b8hyyr	1384	19	desirable	desirable	JJ
cord-006860-a3b8hyyr	1384	20	.	.	.
cord-006860-a3b8hyyr	1385	1	A	a	DT
cord-006860-a3b8hyyr	1385	2	FULLY	fully	RB
cord-006860-a3b8hyyr	1385	3	AUTOMATED	automate	VBN
cord-006860-a3b8hyyr	1385	4	PROCEDURE	procedure	NN
cord-006860-a3b8hyyr	1385	5	FOR	for	IN
cord-006860-a3b8hyyr	1385	6	THE	the	DT
cord-006860-a3b8hyyr	1385	7	REPTILASE	REPTILASE	NNP
cord-006860-a3b8hyyr	1385	8	TIME	time	NN
cord-006860-a3b8hyyr	1385	9	ASSAY	assay	NN
cord-006860-a3b8hyyr	1385	10	Y.	Y.	NNP
cord-006860-a3b8hyyr	1385	11	Schmitt	Schmitt	NNP
cord-006860-a3b8hyyr	1385	12	(	(	-LRB-
cord-006860-a3b8hyyr	1385	13	1	1	CD
cord-006860-a3b8hyyr	1385	14	)	)	-RRB-
cord-006860-a3b8hyyr	1386	1	and	and	CC
cord-006860-a3b8hyyr	1386	2	H.J.	H.J.	NNP
cord-006860-a3b8hyyr	1386	3	Kolde	Kolde	NNP
cord-006860-a3b8hyyr	1386	4	(	(	-LRB-
cord-006860-a3b8hyyr	1386	5	2	2	LS
cord-006860-a3b8hyyr	1386	6	)	)	-RRB-
cord-006860-a3b8hyyr	1386	7	(	(	-LRB-
cord-006860-a3b8hyyr	1386	8	1	1	LS
cord-006860-a3b8hyyr	1386	9	)	)	-RRB-
cord-006860-a3b8hyyr	1386	10	Institute	Institute	NNP
cord-006860-a3b8hyyr	1386	11	for	for	IN
cord-006860-a3b8hyyr	1386	12	Laboratory	Laboratory	NNP
cord-006860-a3b8hyyr	1386	13	Medicine	Medicine	NNP
cord-006860-a3b8hyyr	1386	14	,	,	,
cord-006860-a3b8hyyr	1386	15	St	St	NNP
cord-006860-a3b8hyyr	1386	16	~	~	NNP
cord-006860-a3b8hyyr	1386	17	dtisches	dtisches	NNP
cord-006860-a3b8hyyr	1386	18	Klinikum	Klinikum	NNP
cord-006860-a3b8hyyr	1386	19	,	,	,
cord-006860-a3b8hyyr	1386	20	Darmstadt	Darmstadt	NNP
cord-006860-a3b8hyyr	1386	21	,	,	,
cord-006860-a3b8hyyr	1386	22	FRG	FRG	NNP
cord-006860-a3b8hyyr	1386	23	,	,	,
cord-006860-a3b8hyyr	1386	24	(	(	-LRB-
cord-006860-a3b8hyyr	1386	25	2	2	LS
cord-006860-a3b8hyyr	1386	26	)	)	-RRB-
cord-006860-a3b8hyyr	1386	27	Dade	Dade	NNP
cord-006860-a3b8hyyr	1386	28	Diagnostics	Diagnostics	NNP
cord-006860-a3b8hyyr	1386	29	,	,	,
cord-006860-a3b8hyyr	1386	30	Unterschlei6heim	unterschlei6heim	CD
cord-006860-a3b8hyyr	1387	1	The	the	DT
cord-006860-a3b8hyyr	1387	2	reptilase	reptilase	NN
cord-006860-a3b8hyyr	1387	3	time	time	NN
cord-006860-a3b8hyyr	1387	4	assay	assay	NN
cord-006860-a3b8hyyr	1387	5	is	be	VBZ
cord-006860-a3b8hyyr	1387	6	a	a	DT
cord-006860-a3b8hyyr	1387	7	relatively	relatively	RB
cord-006860-a3b8hyyr	1387	8	simple	simple	JJ
cord-006860-a3b8hyyr	1387	9	technique	technique	NN
cord-006860-a3b8hyyr	1387	10	for	for	IN
cord-006860-a3b8hyyr	1387	11	the	the	DT
cord-006860-a3b8hyyr	1387	12	detection	detection	NN
cord-006860-a3b8hyyr	1387	13	of	of	IN
cord-006860-a3b8hyyr	1387	14	fibrinogen	fibrinogen	JJ
cord-006860-a3b8hyyr	1387	15	degradation	degradation	NN
cord-006860-a3b8hyyr	1387	16	products	product	NNS
cord-006860-a3b8hyyr	1387	17	and	and	CC
cord-006860-a3b8hyyr	1387	18	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1387	19	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1387	20	or	or	CC
cord-006860-a3b8hyyr	1387	21	abnormality	abnormality	NN
cord-006860-a3b8hyyr	1387	22	.	.	.
cord-006860-a3b8hyyr	1388	1	The	the	DT
cord-006860-a3b8hyyr	1388	2	procedure	procedure	NN
cord-006860-a3b8hyyr	1388	3	is	be	VBZ
cord-006860-a3b8hyyr	1388	4	performed	perform	VBN
cord-006860-a3b8hyyr	1388	5	with	with	IN
cord-006860-a3b8hyyr	1388	6	citrated	citrated	JJ
cord-006860-a3b8hyyr	1388	7	plasma	plasma	NN
cord-006860-a3b8hyyr	1388	8	and	and	CC
cord-006860-a3b8hyyr	1388	9	batroxobin	batroxobin	NNP
cord-006860-a3b8hyyr	1388	10	reagent	reagent	NNP
cord-006860-a3b8hyyr	1388	11	,	,	,
cord-006860-a3b8hyyr	1388	12	a	a	DT
cord-006860-a3b8hyyr	1388	13	snake	snake	NN
cord-006860-a3b8hyyr	1388	14	venom	venom	NN
cord-006860-a3b8hyyr	1388	15	enzyme	enzyme	NN
cord-006860-a3b8hyyr	1388	16	from	from	IN
cord-006860-a3b8hyyr	1388	17	Bothrops	Bothrops	NNP
cord-006860-a3b8hyyr	1388	18	atrox	atrox	NNP
cord-006860-a3b8hyyr	1388	19	.	.	.
cord-006860-a3b8hyyr	1389	1	This	this	DT
cord-006860-a3b8hyyr	1389	2	enzyme	enzyme	NN
cord-006860-a3b8hyyr	1389	3	cleaves	cleave	VBZ
cord-006860-a3b8hyyr	1389	4	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1389	5	by	by	IN
cord-006860-a3b8hyyr	1389	6	releasing	release	VBG
cord-006860-a3b8hyyr	1389	7	fibdno	fibdno	NN
cord-006860-a3b8hyyr	1389	8	peptide	peptide	NN
cord-006860-a3b8hyyr	1389	9	A	a	DT
cord-006860-a3b8hyyr	1389	10	only	only	RB
cord-006860-a3b8hyyr	1389	11	but	but	CC
cord-006860-a3b8hyyr	1389	12	not	not	RB
cord-006860-a3b8hyyr	1389	13	fibdno	fibdno	NN
cord-006860-a3b8hyyr	1389	14	peptide	peptide	NNP
cord-006860-a3b8hyyr	1390	1	B.	B.	NNP
cord-006860-a3b8hyyr	1391	1	In	in	IN
cord-006860-a3b8hyyr	1391	2	contrast	contrast	NN
cord-006860-a3b8hyyr	1391	3	to	to	IN
cord-006860-a3b8hyyr	1391	4	the	the	DT
cord-006860-a3b8hyyr	1391	5	physiological	physiological	JJ
cord-006860-a3b8hyyr	1391	6	enzyme	enzyme	NN
cord-006860-a3b8hyyr	1392	1	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1392	2	that	that	WDT
cord-006860-a3b8hyyr	1392	3	is	be	VBZ
cord-006860-a3b8hyyr	1392	4	readily	readily	RB
cord-006860-a3b8hyyr	1392	5	neutralized	neutralize	VBN
cord-006860-a3b8hyyr	1392	6	by	by	IN
cord-006860-a3b8hyyr	1392	7	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	1392	8	III	III	NNP
cord-006860-a3b8hyyr	1392	9	and	and	CC
cord-006860-a3b8hyyr	1392	10	hepadn	hepadn	NNP
cord-006860-a3b8hyyr	1392	11	batroxobin	batroxobin	NNP
cord-006860-a3b8hyyr	1392	12	is	be	VBZ
cord-006860-a3b8hyyr	1392	13	not	not	RB
cord-006860-a3b8hyyr	1392	14	inactivated	inactivate	VBN
cord-006860-a3b8hyyr	1392	15	by	by	IN
cord-006860-a3b8hyyr	1392	16	physiological	physiological	JJ
cord-006860-a3b8hyyr	1392	17	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1392	18	.	.	.
cord-006860-a3b8hyyr	1393	1	At	at	IN
cord-006860-a3b8hyyr	1393	2	present	present	JJ
cord-006860-a3b8hyyr	1393	3	this	this	DT
cord-006860-a3b8hyyr	1393	4	assay	assay	NN
cord-006860-a3b8hyyr	1393	5	is	be	VBZ
cord-006860-a3b8hyyr	1393	6	mainly	mainly	RB
cord-006860-a3b8hyyr	1393	7	performed	perform	VBN
cord-006860-a3b8hyyr	1393	8	manually	manually	RB
cord-006860-a3b8hyyr	1393	9	or	or	CC
cord-006860-a3b8hyyr	1393	10	on	on	IN
cord-006860-a3b8hyyr	1393	11	mechanical	mechanical	JJ
cord-006860-a3b8hyyr	1393	12	instruments	instrument	NNS
cord-006860-a3b8hyyr	1393	13	.	.	.
cord-006860-a3b8hyyr	1394	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1394	2	have	have	VBP
cord-006860-a3b8hyyr	1394	3	adapted	adapt	VBN
cord-006860-a3b8hyyr	1394	4	this	this	DT
cord-006860-a3b8hyyr	1394	5	assay	assay	NN
cord-006860-a3b8hyyr	1394	6	to	to	IN
cord-006860-a3b8hyyr	1394	7	the	the	DT
cord-006860-a3b8hyyr	1394	8	Electra	Electra	NNP
cord-006860-a3b8hyyr	1394	9	1000	1000	CD
cord-006860-a3b8hyyr	1394	10	fully	fully	RB
cord-006860-a3b8hyyr	1394	11	automated	automate	VBN
cord-006860-a3b8hyyr	1394	12	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1394	13	analyzer	analyzer	NN
cord-006860-a3b8hyyr	1394	14	(	(	-LRB-
cord-006860-a3b8hyyr	1394	15	Medical	Medical	NNP
cord-006860-a3b8hyyr	1394	16	Laboratory	Laboratory	NNP
cord-006860-a3b8hyyr	1394	17	Automation	Automation	NNP
cord-006860-a3b8hyyr	1394	18	,	,	,
cord-006860-a3b8hyyr	1394	19	Pleasantville	Pleasantville	NNP
cord-006860-a3b8hyyr	1394	20	,	,	,
cord-006860-a3b8hyyr	1394	21	N.Y.	New York	NNP
cord-006860-a3b8hyyr	1394	22	)	)	-RRB-
cord-006860-a3b8hyyr	1394	23	using	use	VBG
cord-006860-a3b8hyyr	1394	24	the	the	DT
cord-006860-a3b8hyyr	1394	25	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1394	26	clotting	clotting	NN
cord-006860-a3b8hyyr	1394	27	time	time	NN
cord-006860-a3b8hyyr	1394	28	procedure	procedure	NN
cord-006860-a3b8hyyr	1394	29	in	in	IN
cord-006860-a3b8hyyr	1394	30	the	the	DT
cord-006860-a3b8hyyr	1394	31	instrument	instrument	NN
cord-006860-a3b8hyyr	1394	32	software	software	NN
cord-006860-a3b8hyyr	1394	33	with	with	IN
cord-006860-a3b8hyyr	1394	34	batroxobin	batroxobin	NNP
cord-006860-a3b8hyyr	1394	35	reagent	reagent	NNP
cord-006860-a3b8hyyr	1394	36	(	(	-LRB-
cord-006860-a3b8hyyr	1395	1	Dade	Dade	NNP
cord-006860-a3b8hyyr	1395	2	Dia-	Dia-	NNP
cord-006860-a3b8hyyr	1396	1	The	the	DT
cord-006860-a3b8hyyr	1396	2	clot	clot	NN
cord-006860-a3b8hyyr	1396	3	formation	formation	NN
cord-006860-a3b8hyyr	1396	4	is	be	VBZ
cord-006860-a3b8hyyr	1396	5	registrated	registrate	VBN
cord-006860-a3b8hyyr	1396	6	turbidimetrically	turbidimetrically	NN
cord-006860-a3b8hyyr	1396	7	and	and	CC
cord-006860-a3b8hyyr	1396	8	the	the	DT
cord-006860-a3b8hyyr	1396	9	dotting	dotting	NN
cord-006860-a3b8hyyr	1396	10	time	time	NN
cord-006860-a3b8hyyr	1396	11	is	be	VBZ
cord-006860-a3b8hyyr	1396	12	pdnted	pdnte	VBN
cord-006860-a3b8hyyr	1396	13	.	.	.
cord-006860-a3b8hyyr	1397	1	The	the	DT
cord-006860-a3b8hyyr	1397	2	within	within	JJ
cord-006860-a3b8hyyr	1397	3	run	run	NN
cord-006860-a3b8hyyr	1397	4	precision	precision	NN
cord-006860-a3b8hyyr	1397	5	(	(	-LRB-
cord-006860-a3b8hyyr	1397	6	n=	n=	NNP
cord-006860-a3b8hyyr	1397	7	10	10	CD
cord-006860-a3b8hyyr	1397	8	)	)	-RRB-
cord-006860-a3b8hyyr	1397	9	of	of	IN
cord-006860-a3b8hyyr	1397	10	this	this	DT
cord-006860-a3b8hyyr	1397	11	procedure	procedure	NN
cord-006860-a3b8hyyr	1397	12	was	be	VBD
cord-006860-a3b8hyyr	1397	13	tested	test	VBN
cord-006860-a3b8hyyr	1397	14	with	with	IN
cord-006860-a3b8hyyr	1397	15	two	two	CD
cord-006860-a3b8hyyr	1397	16	plasmas	plasma	NNS
cord-006860-a3b8hyyr	1397	17	from	from	IN
cord-006860-a3b8hyyr	1397	18	the	the	DT
cord-006860-a3b8hyyr	1397	19	daily	daily	JJ
cord-006860-a3b8hyyr	1397	20	routine	routine	NN
cord-006860-a3b8hyyr	1397	21	and	and	CC
cord-006860-a3b8hyyr	1397	22	was	be	VBD
cord-006860-a3b8hyyr	1397	23	between	between	IN
cord-006860-a3b8hyyr	1397	24	2.8	2.8	CD
cord-006860-a3b8hyyr	1397	25	and	and	CC
cord-006860-a3b8hyyr	1397	26	3.4	3.4	CD
cord-006860-a3b8hyyr	1397	27	%	%	NN
cord-006860-a3b8hyyr	1397	28	.	.	.
cord-006860-a3b8hyyr	1398	1	In	in	IN
cord-006860-a3b8hyyr	1398	2	25	25	CD
cord-006860-a3b8hyyr	1398	3	normal	normal	JJ
cord-006860-a3b8hyyr	1398	4	samples	sample	NNS
cord-006860-a3b8hyyr	1398	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	1398	6	found	find	VBD
cord-006860-a3b8hyyr	1398	7	clotting	clotting	NN
cord-006860-a3b8hyyr	1398	8	times	time	NNS
cord-006860-a3b8hyyr	1398	9	from	from	IN
cord-006860-a3b8hyyr	1398	10	10.5	10.5	CD
cord-006860-a3b8hyyr	1398	11	to	to	IN
cord-006860-a3b8hyyr	1398	12	12.8	12.8	CD
cord-006860-a3b8hyyr	1398	13	sec	sec	NNP
cord-006860-a3b8hyyr	1398	14	.	.	.
cord-006860-a3b8hyyr	1399	1	In	in	IN
cord-006860-a3b8hyyr	1399	2	30	30	CD
cord-006860-a3b8hyyr	1399	3	samples	sample	NNS
cord-006860-a3b8hyyr	1399	4	with	with	IN
cord-006860-a3b8hyyr	1399	5	liver	liver	NN
cord-006860-a3b8hyyr	1399	6	disease	disease	NN
cord-006860-a3b8hyyr	1399	7	(	(	-LRB-
cord-006860-a3b8hyyr	1399	8	confirmed	confirm	VBN
cord-006860-a3b8hyyr	1399	9	by	by	IN
cord-006860-a3b8hyyr	1399	10	pseudochlinesterase	pseudochlinesterase	NNP
cord-006860-a3b8hyyr	1399	11	<	<	XX
cord-006860-a3b8hyyr	1399	12	2000	2000	CD
cord-006860-a3b8hyyr	1399	13	U	U	NNP
cord-006860-a3b8hyyr	1399	14	/	/	SYM
cord-006860-a3b8hyyr	1399	15	ML	ML	NNP
cord-006860-a3b8hyyr	1399	16	)	)	-RRB-
cord-006860-a3b8hyyr	1399	17	or	or	CC
cord-006860-a3b8hyyr	1399	18	on	on	IN
cord-006860-a3b8hyyr	1399	19	thrombolysis	thrombolysis	NN
cord-006860-a3b8hyyr	1399	20	therapy	therapy	NN
cord-006860-a3b8hyyr	1399	21	with	with	IN
cord-006860-a3b8hyyr	1399	22	streptokinase	streptokinase	NNP
cord-006860-a3b8hyyr	1399	23	or	or	CC
cord-006860-a3b8hyyr	1399	24	urokinase	urokinase	NNP
cord-006860-a3b8hyyr	1399	25	the	the	DT
cord-006860-a3b8hyyr	1399	26	fully	fully	RB
cord-006860-a3b8hyyr	1399	27	automated	automate	VBN
cord-006860-a3b8hyyr	1399	28	assay	assay	NN
cord-006860-a3b8hyyr	1399	29	on	on	IN
cord-006860-a3b8hyyr	1399	30	the	the	DT
cord-006860-a3b8hyyr	1399	31	Electra	Electra	NNP
cord-006860-a3b8hyyr	1399	32	was	be	VBD
cord-006860-a3b8hyyr	1399	33	compared	compare	VBN
cord-006860-a3b8hyyr	1399	34	to	to	IN
cord-006860-a3b8hyyr	1399	35	the	the	DT
cord-006860-a3b8hyyr	1399	36	semiautomatic	semiautomatic	JJ
cord-006860-a3b8hyyr	1399	37	method	method	NN
cord-006860-a3b8hyyr	1399	38	using	use	VBG
cord-006860-a3b8hyyr	1399	39	a	a	DT
cord-006860-a3b8hyyr	1399	40	KC	KC	NNP
cord-006860-a3b8hyyr	1399	41	10	10	CD
cord-006860-a3b8hyyr	1399	42	coagulometer	coagulometer	NN
cord-006860-a3b8hyyr	1399	43	(	(	-LRB-
cord-006860-a3b8hyyr	1399	44	Amelung	Amelung	NNP
cord-006860-a3b8hyyr	1399	45	,	,	,
cord-006860-a3b8hyyr	1399	46	Lemgo	Lemgo	NNP
cord-006860-a3b8hyyr	1399	47	,	,	,
cord-006860-a3b8hyyr	1399	48	Germany	Germany	NNP
cord-006860-a3b8hyyr	1399	49	)	)	-RRB-
cord-006860-a3b8hyyr	1399	50	based	base	VBN
cord-006860-a3b8hyyr	1399	51	on	on	IN
cord-006860-a3b8hyyr	1399	52	a	a	DT
cord-006860-a3b8hyyr	1399	53	rolling	rolling	JJ
cord-006860-a3b8hyyr	1399	54	metal	metal	NN
cord-006860-a3b8hyyr	1399	55	ball	ball	NN
cord-006860-a3b8hyyr	1399	56	pdnciple	pdnciple	NN
cord-006860-a3b8hyyr	1399	57	and	and	CC
cord-006860-a3b8hyyr	1399	58	magnetic	magnetic	JJ
cord-006860-a3b8hyyr	1399	59	endpoint	endpoint	NN
cord-006860-a3b8hyyr	1399	60	detection	detection	NN
cord-006860-a3b8hyyr	1399	61	.	.	.
cord-006860-a3b8hyyr	1400	1	The	the	DT
cord-006860-a3b8hyyr	1400	2	two	two	CD
cord-006860-a3b8hyyr	1400	3	assays	assay	NNS
cord-006860-a3b8hyyr	1400	4	agreed	agree	VBD
cord-006860-a3b8hyyr	1400	5	very	very	RB
cord-006860-a3b8hyyr	1400	6	well	well	RB
cord-006860-a3b8hyyr	1400	7	with	with	IN
cord-006860-a3b8hyyr	1400	8	a	a	DT
cord-006860-a3b8hyyr	1400	9	correlation	correlation	NN
cord-006860-a3b8hyyr	1400	10	coefficient	coefficient	NN
cord-006860-a3b8hyyr	1400	11	of	of	IN
cord-006860-a3b8hyyr	1400	12	r	r	NN
cord-006860-a3b8hyyr	1400	13	=	=	SYM
cord-006860-a3b8hyyr	1400	14	0,948	0,948	CD
cord-006860-a3b8hyyr	1400	15	and	and	CC
cord-006860-a3b8hyyr	1400	16	a	a	DT
cord-006860-a3b8hyyr	1400	17	regression	regression	NN
cord-006860-a3b8hyyr	1400	18	line	line	NN
cord-006860-a3b8hyyr	1400	19	according	accord	VBG
cord-006860-a3b8hyyr	1400	20	to	to	IN
cord-006860-a3b8hyyr	1400	21	Passing	Passing	NNP
cord-006860-a3b8hyyr	1400	22	and	and	CC
cord-006860-a3b8hyyr	1400	23	Bablok	Bablok	NNP
cord-006860-a3b8hyyr	1400	24	of	of	IN
cord-006860-a3b8hyyr	1400	25	y	y	NNP
cord-006860-a3b8hyyr	1400	26	=	=	SYM
cord-006860-a3b8hyyr	1400	27	1.0	1.0	CD
cord-006860-a3b8hyyr	1400	28	x	x	SYM
cord-006860-a3b8hyyr	1400	29	+	+	SYM
cord-006860-a3b8hyyr	1400	30	1.7	1.7	CD
cord-006860-a3b8hyyr	1400	31	.	.	.
cord-006860-a3b8hyyr	1401	1	These	these	DT
cord-006860-a3b8hyyr	1401	2	data	datum	NNS
cord-006860-a3b8hyyr	1401	3	show	show	VBP
cord-006860-a3b8hyyr	1401	4	that	that	IN
cord-006860-a3b8hyyr	1401	5	the	the	DT
cord-006860-a3b8hyyr	1401	6	reptilase	reptilase	NNP
cord-006860-a3b8hyyr	1401	7	time	time	NN
cord-006860-a3b8hyyr	1401	8	can	can	MD
cord-006860-a3b8hyyr	1401	9	be	be	VB
cord-006860-a3b8hyyr	1401	10	performed	perform	VBN
cord-006860-a3b8hyyr	1401	11	with	with	IN
cord-006860-a3b8hyyr	1401	12	good	good	JJ
cord-006860-a3b8hyyr	1401	13	precision	precision	NN
cord-006860-a3b8hyyr	1401	14	and	and	CC
cord-006860-a3b8hyyr	1401	15	with	with	IN
cord-006860-a3b8hyyr	1401	16	good	good	JJ
cord-006860-a3b8hyyr	1401	17	correlation	correlation	NN
cord-006860-a3b8hyyr	1401	18	to	to	IN
cord-006860-a3b8hyyr	1401	19	the	the	DT
cord-006860-a3b8hyyr	1401	20	manual	manual	JJ
cord-006860-a3b8hyyr	1401	21	technique	technique	NN
cord-006860-a3b8hyyr	1401	22	on	on	IN
cord-006860-a3b8hyyr	1401	23	mechanical	mechanical	JJ
cord-006860-a3b8hyyr	1401	24	instruments	instrument	NNS
cord-006860-a3b8hyyr	1401	25	on	on	IN
cord-006860-a3b8hyyr	1401	26	the	the	DT
cord-006860-a3b8hyyr	1401	27	Electra	Electra	NNP
cord-006860-a3b8hyyr	1401	28	1000	1000	CD
cord-006860-a3b8hyyr	1401	29	.	.	.
cord-006860-a3b8hyyr	1402	1	Introduction	introduction	NN
cord-006860-a3b8hyyr	1402	2	:	:	:
cord-006860-a3b8hyyr	1402	3	Disseminated	disseminate	VBN
cord-006860-a3b8hyyr	1402	4	Intravasal	Intravasal	NNP
cord-006860-a3b8hyyr	1402	5	Coagulation	Coagulation	NNP
cord-006860-a3b8hyyr	1402	6	(	(	-LRB-
cord-006860-a3b8hyyr	1402	7	DIC	DIC	NNP
cord-006860-a3b8hyyr	1402	8	)	)	-RRB-
cord-006860-a3b8hyyr	1402	9	,	,	,
cord-006860-a3b8hyyr	1402	10	due	due	IN
cord-006860-a3b8hyyr	1402	11	to	to	IN
cord-006860-a3b8hyyr	1402	12	a	a	DT
cord-006860-a3b8hyyr	1402	13	massive	massive	JJ
cord-006860-a3b8hyyr	1402	14	activation	activation	NN
cord-006860-a3b8hyyr	1402	15	of	of	IN
cord-006860-a3b8hyyr	1402	16	the	the	DT
cord-006860-a3b8hyyr	1402	17	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1402	18	system	system	NN
cord-006860-a3b8hyyr	1402	19	,	,	,
cord-006860-a3b8hyyr	1402	20	is	be	VBZ
cord-006860-a3b8hyyr	1402	21	frequently	frequently	RB
cord-006860-a3b8hyyr	1402	22	observed	observe	VBN
cord-006860-a3b8hyyr	1402	23	in	in	IN
cord-006860-a3b8hyyr	1402	24	intensive	intensive	JJ
cord-006860-a3b8hyyr	1402	25	care	care	NN
cord-006860-a3b8hyyr	1402	26	patients	patient	NNS
cord-006860-a3b8hyyr	1402	27	suffering	suffer	VBG
cord-006860-a3b8hyyr	1402	28	from	from	IN
cord-006860-a3b8hyyr	1402	29	severe	severe	JJ
cord-006860-a3b8hyyr	1402	30	underlying	underlie	VBG
cord-006860-a3b8hyyr	1402	31	diseases	disease	NNS
cord-006860-a3b8hyyr	1402	32	.	.	.
cord-006860-a3b8hyyr	1403	1	Laboratory	laboratory	NN
cord-006860-a3b8hyyr	1403	2	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	1403	3	of	of	IN
cord-006860-a3b8hyyr	1403	4	DIC	DIC	NNP
cord-006860-a3b8hyyr	1403	5	is	be	VBZ
cord-006860-a3b8hyyr	1403	6	based	base	VBN
cord-006860-a3b8hyyr	1403	7	on	on	IN
cord-006860-a3b8hyyr	1403	8	different	different	JJ
cord-006860-a3b8hyyr	1403	9	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1403	10	tests	test	NNS
cord-006860-a3b8hyyr	1403	11	,	,	,
cord-006860-a3b8hyyr	1403	12	but	but	CC
cord-006860-a3b8hyyr	1403	13	unfortunately	unfortunately	RB
cord-006860-a3b8hyyr	1403	14	the	the	DT
cord-006860-a3b8hyyr	1403	15	routine	routine	JJ
cord-006860-a3b8hyyr	1403	16	haemostaseological	haemostaseological	JJ
cord-006860-a3b8hyyr	1403	17	parameters	parameter	NNS
cord-006860-a3b8hyyr	1403	18	react	react	VBP
cord-006860-a3b8hyyr	1403	19	with	with	IN
cord-006860-a3b8hyyr	1403	20	latency	latency	NN
cord-006860-a3b8hyyr	1403	21	in	in	IN
cord-006860-a3b8hyyr	1403	22	the	the	DT
cord-006860-a3b8hyyr	1403	23	course	course	NN
cord-006860-a3b8hyyr	1403	24	of	of	IN
cord-006860-a3b8hyyr	1403	25	acute	acute	JJ
cord-006860-a3b8hyyr	1403	26	DIC	DIC	NNP
cord-006860-a3b8hyyr	1403	27	Objective	Objective	NNP
cord-006860-a3b8hyyr	1403	28	:	:	:
cord-006860-a3b8hyyr	1403	29	In	in	IN
cord-006860-a3b8hyyr	1403	30	four	four	CD
cord-006860-a3b8hyyr	1403	31	cases	case	NNS
cord-006860-a3b8hyyr	1403	32	from	from	IN
cord-006860-a3b8hyyr	1403	33	a	a	DT
cord-006860-a3b8hyyr	1403	34	cohort	cohort	NN
cord-006860-a3b8hyyr	1403	35	of	of	IN
cord-006860-a3b8hyyr	1403	36	43	43	CD
cord-006860-a3b8hyyr	1403	37	patients	patient	NNS
cord-006860-a3b8hyyr	1403	38	with	with	IN
cord-006860-a3b8hyyr	1403	39	severe	severe	JJ
cord-006860-a3b8hyyr	1403	40	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1404	1	and	and	CC
cord-006860-a3b8hyyr	1404	2	DIC	DIC	NNP
cord-006860-a3b8hyyr	1404	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	1404	4	analysed	analyse	VBD
cord-006860-a3b8hyyr	1404	5	special	special	JJ
cord-006860-a3b8hyyr	1404	6	haemostaseological	haemostaseological	JJ
cord-006860-a3b8hyyr	1404	7	parameters	parameter	NNS
cord-006860-a3b8hyyr	1404	8	(	(	-LRB-
cord-006860-a3b8hyyr	1404	9	TAT	TAT	NNP
cord-006860-a3b8hyyr	1404	10	,	,	,
cord-006860-a3b8hyyr	1404	11	F1-T2	F1-T2	NNP
cord-006860-a3b8hyyr	1404	12	,	,	,
cord-006860-a3b8hyyr	1404	13	D	D	NNP
cord-006860-a3b8hyyr	1404	14	-	-	HYPH
cord-006860-a3b8hyyr	1404	15	Dimers	Dimers	NNPS
cord-006860-a3b8hyyr	1404	16	,	,	,
cord-006860-a3b8hyyr	1404	17	Human	Human	NNP
cord-006860-a3b8hyyr	1404	18	-	-	HYPH
cord-006860-a3b8hyyr	1404	19	Leucocyte	Leucocyte	NNP
cord-006860-a3b8hyyr	1404	20	-	-	HYPH
cord-006860-a3b8hyyr	1404	21	Elastese	Elastese	NNP
cord-006860-a3b8hyyr	1404	22	(	(	-LRB-
cord-006860-a3b8hyyr	1404	23	FILE	FILE	NNP
cord-006860-a3b8hyyr	1404	24	)	)	-RRB-
cord-006860-a3b8hyyr	1404	25	,	,	,
cord-006860-a3b8hyyr	1404	26	Catepsin	Catepsin	NNP
cord-006860-a3b8hyyr	1404	27	G	G	NNP
cord-006860-a3b8hyyr	1404	28	and	and	CC
cord-006860-a3b8hyyr	1404	29	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	1404	30	Cofactor	Cofactor	NNP
cord-006860-a3b8hyyr	1404	31	II	II	NNP
cord-006860-a3b8hyyr	1404	32	(	(	-LRB-
cord-006860-a3b8hyyr	1404	33	HC	HC	NNP
cord-006860-a3b8hyyr	1404	34	II	II	NNP
cord-006860-a3b8hyyr	1404	35	)	)	-RRB-
cord-006860-a3b8hyyr	1404	36	)	)	-RRB-
cord-006860-a3b8hyyr	1404	37	and	and	CC
cord-006860-a3b8hyyr	1404	38	correlated	correlate	VBD
cord-006860-a3b8hyyr	1404	39	them	-PRON-	PRP
cord-006860-a3b8hyyr	1404	40	with	with	IN
cord-006860-a3b8hyyr	1404	41	a	a	DT
cord-006860-a3b8hyyr	1404	42	MOF	MOF	NNP
cord-006860-a3b8hyyr	1404	43	-	-	HYPH
cord-006860-a3b8hyyr	1404	44	score	score	NN
cord-006860-a3b8hyyr	1404	45	in	in	IN
cord-006860-a3b8hyyr	1404	46	order	order	NN
cord-006860-a3b8hyyr	1404	47	to	to	TO
cord-006860-a3b8hyyr	1404	48	test	test	VB
cord-006860-a3b8hyyr	1404	49	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1404	50	predictability	predictability	NN
cord-006860-a3b8hyyr	1404	51	on	on	IN
cord-006860-a3b8hyyr	1404	52	the	the	DT
cord-006860-a3b8hyyr	1404	53	prognosis	prognosis	NN
cord-006860-a3b8hyyr	1404	54	of	of	IN
cord-006860-a3b8hyyr	1404	55	these	these	DT
cord-006860-a3b8hyyr	1404	56	patients	patient	NNS
cord-006860-a3b8hyyr	1404	57	.	.	.
cord-006860-a3b8hyyr	1405	1	Results	result	NNS
cord-006860-a3b8hyyr	1405	2	:	:	:
cord-006860-a3b8hyyr	1406	1	All	all	DT
cord-006860-a3b8hyyr	1406	2	patients	patient	NNS
cord-006860-a3b8hyyr	1406	3	were	be	VBD
cord-006860-a3b8hyyr	1406	4	substituted	substitute	VBN
cord-006860-a3b8hyyr	1406	5	with	with	IN
cord-006860-a3b8hyyr	1406	6	AT	AT	NNP
cord-006860-a3b8hyyr	1406	7	III	iii	CD
cord-006860-a3b8hyyr	1406	8	concentrate	concentrate	NN
cord-006860-a3b8hyyr	1406	9	.	.	.
cord-006860-a3b8hyyr	1407	1	L,1	L,1	NNP
cord-006860-a3b8hyyr	1407	2	the	the	DT
cord-006860-a3b8hyyr	1407	3	investigated	investigate	VBN
cord-006860-a3b8hyyr	1407	4	patients	patient	NNS
cord-006860-a3b8hyyr	1407	5	median	median	JJ
cord-006860-a3b8hyyr	1407	6	time	time	NN
cord-006860-a3b8hyyr	1407	7	of	of	IN
cord-006860-a3b8hyyr	1407	8	treatment	treatment	NN
cord-006860-a3b8hyyr	1407	9	with	with	IN
cord-006860-a3b8hyyr	1407	10	AT	AT	NNP
cord-006860-a3b8hyyr	1407	11	III	III	NNP
cord-006860-a3b8hyyr	1407	12	concentrate	concentrate	NN
cord-006860-a3b8hyyr	1407	13	was	be	VBD
cord-006860-a3b8hyyr	1407	14	8	8	CD
cord-006860-a3b8hyyr	1407	15	(	(	-LRB-
cord-006860-a3b8hyyr	1407	16	6	6	CD
cord-006860-a3b8hyyr	1407	17	-	-	SYM
cord-006860-a3b8hyyr	1407	18	9	9	CD
cord-006860-a3b8hyyr	1407	19	)	)	-RRB-
cord-006860-a3b8hyyr	1407	20	days	day	NNS
cord-006860-a3b8hyyr	1407	21	and	and	CC
cord-006860-a3b8hyyr	1407	22	median	median	JJ
cord-006860-a3b8hyyr	1407	23	time	time	NN
cord-006860-a3b8hyyr	1407	24	of	of	IN
cord-006860-a3b8hyyr	1407	25	DIC	dic	JJ
cord-006860-a3b8hyyr	1407	26	-	-	HYPH
cord-006860-a3b8hyyr	1407	27	duration	duration	NN
cord-006860-a3b8hyyr	1408	1	was	be	VBD
cord-006860-a3b8hyyr	1408	2	6	6	CD
cord-006860-a3b8hyyr	1408	3	(	(	-LRB-
cord-006860-a3b8hyyr	1408	4	4	4	CD
cord-006860-a3b8hyyr	1408	5	-	-	SYM
cord-006860-a3b8hyyr	1408	6	8	8	CD
cord-006860-a3b8hyyr	1408	7	)	)	-RRB-
cord-006860-a3b8hyyr	1408	8	days	day	NNS
cord-006860-a3b8hyyr	1408	9	.	.	.
cord-006860-a3b8hyyr	1409	1	None	none	NN
cord-006860-a3b8hyyr	1409	2	of	of	IN
cord-006860-a3b8hyyr	1409	3	the	the	DT
cord-006860-a3b8hyyr	1409	4	presented	present	VBN
cord-006860-a3b8hyyr	1409	5	patients	patient	NNS
cord-006860-a3b8hyyr	1409	6	died	die	VBD
cord-006860-a3b8hyyr	1409	7	during	during	IN
cord-006860-a3b8hyyr	1409	8	observation	observation	NN
cord-006860-a3b8hyyr	1409	9	period	period	NN
cord-006860-a3b8hyyr	1409	10	.	.	.
cord-006860-a3b8hyyr	1410	1	All	all	DT
cord-006860-a3b8hyyr	1410	2	analysed	analyse	VBN
cord-006860-a3b8hyyr	1410	3	parameters	parameter	NNS
cord-006860-a3b8hyyr	1410	4	,	,	,
cord-006860-a3b8hyyr	1410	5	except	except	IN
cord-006860-a3b8hyyr	1410	6	D	d	NN
cord-006860-a3b8hyyr	1410	7	-	-	HYPH
cord-006860-a3b8hyyr	1410	8	Dimers	Dimers	NNPS
cord-006860-a3b8hyyr	1410	9	,	,	,
cord-006860-a3b8hyyr	1410	10	showed	show	VBD
cord-006860-a3b8hyyr	1410	11	a	a	DT
cord-006860-a3b8hyyr	1410	12	sufficient	sufficient	JJ
cord-006860-a3b8hyyr	1410	13	correlation	correlation	NN
cord-006860-a3b8hyyr	1410	14	with	with	IN
cord-006860-a3b8hyyr	1410	15	the	the	DT
cord-006860-a3b8hyyr	1410	16	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	1410	17	MOF	MOF	NNP
cord-006860-a3b8hyyr	1410	18	-	-	HYPH
cord-006860-a3b8hyyr	1410	19	score	score	NN
cord-006860-a3b8hyyr	1410	20	(	(	-LRB-
cord-006860-a3b8hyyr	1410	21	TAT	tat	NN
cord-006860-a3b8hyyr	1410	22	:	:	:
cord-006860-a3b8hyyr	1411	1	r=	r=	NN
cord-006860-a3b8hyyr	1411	2	0,78	0,78	NNS
cord-006860-a3b8hyyr	1411	3	;	;	.
cord-006860-a3b8hyyr	1412	1	F1-F2	f1-f2	NN
cord-006860-a3b8hyyr	1412	2	:	:	:
cord-006860-a3b8hyyr	1413	1	r=	r=	NN
cord-006860-a3b8hyyr	1413	2	0,84	0,84	XX
cord-006860-a3b8hyyr	1413	3	;	;	:
cord-006860-a3b8hyyr	1413	4	HLE	HLE	NNP
cord-006860-a3b8hyyr	1413	5	:	:	:
cord-006860-a3b8hyyr	1414	1	r=	r=	JJ
cord-006860-a3b8hyyr	1414	2	0,71	0,71	CD
cord-006860-a3b8hyyr	1414	3	;	;	:
cord-006860-a3b8hyyr	1414	4	Catepsin	Catepsin	NNP
cord-006860-a3b8hyyr	1414	5	G	G	NNP
cord-006860-a3b8hyyr	1414	6	:	:	:
cord-006860-a3b8hyyr	1414	7	r=-0,75	r=-0,75	NNP
cord-006860-a3b8hyyr	1414	8	;	;	:
cord-006860-a3b8hyyr	1414	9	HC	HC	NNP
cord-006860-a3b8hyyr	1414	10	II	II	NNP
cord-006860-a3b8hyyr	1414	11	:	:	:
cord-006860-a3b8hyyr	1414	12	1"=-0,88	1"=-0,88	CD
cord-006860-a3b8hyyr	1414	13	)	)	-RRB-
cord-006860-a3b8hyyr	1414	14	.	.	.
cord-006860-a3b8hyyr	1415	1	The	the	DT
cord-006860-a3b8hyyr	1415	2	D	D	NNP
cord-006860-a3b8hyyr	1415	3	-	-	HYPH
cord-006860-a3b8hyyr	1415	4	Dimers	Dimers	NNPS
cord-006860-a3b8hyyr	1415	5	did	do	VBD
cord-006860-a3b8hyyr	1415	6	not	not	RB
cord-006860-a3b8hyyr	1415	7	correlate	correlate	VB
cord-006860-a3b8hyyr	1415	8	with	with	IN
cord-006860-a3b8hyyr	1415	9	the	the	DT
cord-006860-a3b8hyyr	1415	10	MOF	MOF	NNP
cord-006860-a3b8hyyr	1415	11	-	-	HYPH
cord-006860-a3b8hyyr	1415	12	score	score	NN
cord-006860-a3b8hyyr	1415	13	,	,	,
cord-006860-a3b8hyyr	1415	14	which	which	WDT
cord-006860-a3b8hyyr	1415	15	is	be	VBZ
cord-006860-a3b8hyyr	1415	16	probably	probably	RB
cord-006860-a3b8hyyr	1415	17	due	due	JJ
cord-006860-a3b8hyyr	1415	18	to	to	IN
cord-006860-a3b8hyyr	1415	19	the	the	DT
cord-006860-a3b8hyyr	1415	20	delayed	delay	VBN
cord-006860-a3b8hyyr	1415	21	reactive	reactive	JJ
cord-006860-a3b8hyyr	1415	22	hyperfibrinolysis	hyperfibrinolysis	NN
cord-006860-a3b8hyyr	1415	23	in	in	IN
cord-006860-a3b8hyyr	1415	24	the	the	DT
cord-006860-a3b8hyyr	1415	25	course	course	NN
cord-006860-a3b8hyyr	1415	26	of	of	IN
cord-006860-a3b8hyyr	1415	27	DIC	DIC	NNP
cord-006860-a3b8hyyr	1415	28	.	.	.
cord-006860-a3b8hyyr	1416	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	1416	2	,	,	,
cord-006860-a3b8hyyr	1416	3	the	the	DT
cord-006860-a3b8hyyr	1416	4	decrease	decrease	NN
cord-006860-a3b8hyyr	1416	5	of	of	IN
cord-006860-a3b8hyyr	1416	6	the	the	DT
cord-006860-a3b8hyyr	1416	7	TAT	tat	NN
cord-006860-a3b8hyyr	1416	8	-	-	HYPH
cord-006860-a3b8hyyr	1416	9	complexes	complex	NNS
cord-006860-a3b8hyyr	1416	10	,	,	,
cord-006860-a3b8hyyr	1416	11	F1-F2	F1-F2	NNP
cord-006860-a3b8hyyr	1416	12	,	,	,
cord-006860-a3b8hyyr	1416	13	HLE	HLE	NNP
cord-006860-a3b8hyyr	1416	14	and	and	CC
cord-006860-a3b8hyyr	1416	15	Catepsin	Catepsin	NNP
cord-006860-a3b8hyyr	1416	16	G	G	NNP
cord-006860-a3b8hyyr	1416	17	levels	level	NNS
cord-006860-a3b8hyyr	1416	18	were	be	VBD
cord-006860-a3b8hyyr	1416	19	followed	follow	VBN
cord-006860-a3b8hyyr	1416	20	by	by	IN
cord-006860-a3b8hyyr	1416	21	an	an	DT
cord-006860-a3b8hyyr	1416	22	increase	increase	NN
cord-006860-a3b8hyyr	1416	23	of	of	IN
cord-006860-a3b8hyyr	1416	24	AT	AT	NNP
cord-006860-a3b8hyyr	1416	25	HI	HI	NNP
cord-006860-a3b8hyyr	1416	26	and	and	CC
cord-006860-a3b8hyyr	1416	27	HC	HC	NNP
cord-006860-a3b8hyyr	1416	28	II	II	NNP
cord-006860-a3b8hyyr	1416	29	activity	activity	NN
cord-006860-a3b8hyyr	1416	30	.	.	.
cord-006860-a3b8hyyr	1417	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	1417	2	:	:	:
cord-006860-a3b8hyyr	1418	1	In	in	IN
cord-006860-a3b8hyyr	1418	2	general	general	JJ
cord-006860-a3b8hyyr	1418	3	the	the	DT
cord-006860-a3b8hyyr	1418	4	analysed	analyse	VBN
cord-006860-a3b8hyyr	1418	5	activation	activation	NN
cord-006860-a3b8hyyr	1418	6	markers	marker	NNS
cord-006860-a3b8hyyr	1418	7	and	and	CC
cord-006860-a3b8hyyr	1418	8	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1418	9	parameters	parameter	NNS
cord-006860-a3b8hyyr	1418	10	are	be	VBP
cord-006860-a3b8hyyr	1418	11	sufficiently	sufficiently	RB
cord-006860-a3b8hyyr	1418	12	to	to	TO
cord-006860-a3b8hyyr	1418	13	describe	describe	VB
cord-006860-a3b8hyyr	1418	14	the	the	DT
cord-006860-a3b8hyyr	1418	15	ongoing	ongoing	JJ
cord-006860-a3b8hyyr	1418	16	process	process	NN
cord-006860-a3b8hyyr	1418	17	of	of	IN
cord-006860-a3b8hyyr	1418	18	the	the	DT
cord-006860-a3b8hyyr	1418	19	DIC	DIC	NNP
cord-006860-a3b8hyyr	1418	20	.	.	.
cord-006860-a3b8hyyr	1419	1	The	the	DT
cord-006860-a3b8hyyr	1419	2	hyperfibrinolytic	hyperfibrinolytic	JJ
cord-006860-a3b8hyyr	1419	3	activity	activity	NN
cord-006860-a3b8hyyr	1419	4	of	of	IN
cord-006860-a3b8hyyr	1419	5	DIC	DIC	NNP
cord-006860-a3b8hyyr	1419	6	is	be	VBZ
cord-006860-a3b8hyyr	1419	7	sufficiently	sufficiently	RB
cord-006860-a3b8hyyr	1419	8	represented	represent	VBN
cord-006860-a3b8hyyr	1419	9	by	by	IN
cord-006860-a3b8hyyr	1419	10	the	the	DT
cord-006860-a3b8hyyr	1419	11	D	D	NNP
cord-006860-a3b8hyyr	1419	12	-	-	HYPH
cord-006860-a3b8hyyr	1419	13	Dimer	Dimer	NNP
cord-006860-a3b8hyyr	1419	14	test	test	NN
cord-006860-a3b8hyyr	1419	15	,	,	,
cord-006860-a3b8hyyr	1419	16	but	but	CC
cord-006860-a3b8hyyr	1419	17	is	be	VBZ
cord-006860-a3b8hyyr	1419	18	of	of	IN
cord-006860-a3b8hyyr	1419	19	defered	defer	VBN
cord-006860-a3b8hyyr	1419	20	reactivity	reactivity	NN
cord-006860-a3b8hyyr	1419	21	in	in	IN
cord-006860-a3b8hyyr	1419	22	the	the	DT
cord-006860-a3b8hyyr	1419	23	course	course	NN
cord-006860-a3b8hyyr	1419	24	of	of	IN
cord-006860-a3b8hyyr	1419	25	DIC	DIC	NNP
cord-006860-a3b8hyyr	1419	26	.	.	.
cord-006860-a3b8hyyr	1420	1	Unfortunately	unfortunately	RB
cord-006860-a3b8hyyr	1420	2	these	these	DT
cord-006860-a3b8hyyr	1420	3	parameters	parameter	NNS
cord-006860-a3b8hyyr	1420	4	are	be	VBP
cord-006860-a3b8hyyr	1420	5	not	not	RB
cord-006860-a3b8hyyr	1420	6	established	establish	VBN
cord-006860-a3b8hyyr	1420	7	in	in	IN
cord-006860-a3b8hyyr	1420	8	the	the	DT
cord-006860-a3b8hyyr	1420	9	routine	routine	JJ
cord-006860-a3b8hyyr	1420	10	monitoring	monitoring	NN
cord-006860-a3b8hyyr	1420	11	of	of	IN
cord-006860-a3b8hyyr	1420	12	DIC	DIC	NNP
cord-006860-a3b8hyyr	1420	13	on	on	IN
cord-006860-a3b8hyyr	1420	14	intensive	intensive	JJ
cord-006860-a3b8hyyr	1420	15	care	care	NN
cord-006860-a3b8hyyr	1420	16	units	unit	NNS
cord-006860-a3b8hyyr	1420	17	and	and	CC
cord-006860-a3b8hyyr	1420	18	therefore	therefore	RB
cord-006860-a3b8hyyr	1420	19	further	further	JJ
cord-006860-a3b8hyyr	1420	20	studies	study	NNS
cord-006860-a3b8hyyr	1420	21	are	be	VBP
cord-006860-a3b8hyyr	1420	22	needed	need	VBN
cord-006860-a3b8hyyr	1420	23	to	to	TO
cord-006860-a3b8hyyr	1420	24	investigate	investigate	VB
cord-006860-a3b8hyyr	1420	25	the	the	DT
cord-006860-a3b8hyyr	1420	26	practicability	practicability	NN
cord-006860-a3b8hyyr	1420	27	and	and	CC
cord-006860-a3b8hyyr	1420	28	reliability	reliability	NN
cord-006860-a3b8hyyr	1420	29	in	in	IN
cord-006860-a3b8hyyr	1420	30	the	the	DT
cord-006860-a3b8hyyr	1420	31	daily	daily	JJ
cord-006860-a3b8hyyr	1420	32	routine	routine	JJ
cord-006860-a3b8hyyr	1420	33	monitoring	monitoring	NN
cord-006860-a3b8hyyr	1420	34	.	.	.
cord-006860-a3b8hyyr	1421	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1421	2	have	have	VBP
cord-006860-a3b8hyyr	1421	3	previously	previously	RB
cord-006860-a3b8hyyr	1421	4	reported	report	VBN
cord-006860-a3b8hyyr	1421	5	that	that	IN
cord-006860-a3b8hyyr	1421	6	Notoginsenoside	Notoginsenoside	NNP
cord-006860-a3b8hyyr	1421	7	R1	R1	NNP
cord-006860-a3b8hyyr	1421	8	(	(	-LRB-
cord-006860-a3b8hyyr	1421	9	NG	NG	NNP
cord-006860-a3b8hyyr	1421	10	-	-	HYPH
cord-006860-a3b8hyyr	1421	11	R1	R1	NNP
cord-006860-a3b8hyyr	1421	12	)	)	-RRB-
cord-006860-a3b8hyyr	1421	13	has	have	VBZ
cord-006860-a3b8hyyr	1421	14	an	an	DT
cord-006860-a3b8hyyr	1421	15	effect	effect	NN
cord-006860-a3b8hyyr	1421	16	on	on	IN
cord-006860-a3b8hyyr	1421	17	counteracting	counteract	VBG
cord-006860-a3b8hyyr	1421	18	lipopolysaccharide	lipopolysaccharide	NN
cord-006860-a3b8hyyr	1421	19	(	(	-LRB-
cord-006860-a3b8hyyr	1421	20	LPS	LPS	NNP
cord-006860-a3b8hyyr	1421	21	)	)	-RRB-
cord-006860-a3b8hyyr	1421	22	induced	induce	VBD
cord-006860-a3b8hyyr	1421	23	upregulation	upregulation	NN
cord-006860-a3b8hyyr	1421	24	of	of	IN
cord-006860-a3b8hyyr	1421	25	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	1421	26	activator	activator	NN
cord-006860-a3b8hyyr	1421	27	inhibitor-1	inhibitor-1	NNP
cord-006860-a3b8hyyr	1421	28	and	and	CC
cord-006860-a3b8hyyr	1421	29	tissue	tissue	NN
cord-006860-a3b8hyyr	1421	30	factor	factor	NN
cord-006860-a3b8hyyr	1421	31	expression	expression	NN
cord-006860-a3b8hyyr	1421	32	in	in	IN
cord-006860-a3b8hyyr	1421	33	cultured	cultured	JJ
cord-006860-a3b8hyyr	1421	34	human	human	JJ
cord-006860-a3b8hyyr	1421	35	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	1421	36	vein	vein	NN
cord-006860-a3b8hyyr	1421	37	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1421	38	ceils	ceil	NNS
cord-006860-a3b8hyyr	1421	39	in	in	IN
cord-006860-a3b8hyyr	1421	40	vitro	vitro	FW
cord-006860-a3b8hyyr	1421	41	and	and	CC
cord-006860-a3b8hyyr	1421	42	in	in	IN
cord-006860-a3b8hyyr	1421	43	mice	mouse	NNS
cord-006860-a3b8hyyr	1421	44	in	in	IN
cord-006860-a3b8hyyr	1421	45	vivo	vivo	NNP
cord-006860-a3b8hyyr	1422	1	[	[	-LRB-
cord-006860-a3b8hyyr	1422	2	Fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1422	3	1994;8:(suppl	1994;8:(suppl	NNP
cord-006860-a3b8hyyr	1422	4	1)119	1)119	CD
cord-006860-a3b8hyyr	1422	5	]	]	-RRB-
cord-006860-a3b8hyyr	1422	6	.	.	.
cord-006860-a3b8hyyr	1423	1	In	in	IN
cord-006860-a3b8hyyr	1423	2	this	this	DT
cord-006860-a3b8hyyr	1423	3	study	study	NN
cord-006860-a3b8hyyr	1423	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	1423	5	investigated	investigate	VBD
cord-006860-a3b8hyyr	1423	6	the	the	DT
cord-006860-a3b8hyyr	1423	7	effect	effect	NN
cord-006860-a3b8hyyr	1423	8	of	of	IN
cord-006860-a3b8hyyr	1423	9	NG	NG	NNP
cord-006860-a3b8hyyr	1423	10	-	-	HYPH
cord-006860-a3b8hyyr	1423	11	R1	R1	NNP
cord-006860-a3b8hyyr	1423	12	on	on	IN
cord-006860-a3b8hyyr	1423	13	prevention	prevention	NN
cord-006860-a3b8hyyr	1423	14	of	of	IN
cord-006860-a3b8hyyr	1423	15	LPS	LPS	NNP
cord-006860-a3b8hyyr	1423	16	induced	induce	VBD
cord-006860-a3b8hyyr	1423	17	lethal	lethal	JJ
cord-006860-a3b8hyyr	1423	18	toxicity	toxicity	NN
cord-006860-a3b8hyyr	1423	19	in	in	IN
cord-006860-a3b8hyyr	1423	20	mice	mouse	NNS
cord-006860-a3b8hyyr	1423	21	.	.	.
cord-006860-a3b8hyyr	1424	1	Because	because	IN
cord-006860-a3b8hyyr	1424	2	mice	mouse	NNS
cord-006860-a3b8hyyr	1424	3	are	be	VBP
cord-006860-a3b8hyyr	1424	4	relatively	relatively	RB
cord-006860-a3b8hyyr	1424	5	resistant	resistant	JJ
cord-006860-a3b8hyyr	1424	6	to	to	IN
cord-006860-a3b8hyyr	1424	7	LPS	LPS	NNP
cord-006860-a3b8hyyr	1424	8	when	when	WRB
cord-006860-a3b8hyyr	1424	9	applied	apply	VBD
cord-006860-a3b8hyyr	1424	10	as	as	IN
cord-006860-a3b8hyyr	1424	11	a	a	DT
cord-006860-a3b8hyyr	1424	12	single	single	JJ
cord-006860-a3b8hyyr	1424	13	agent	agent	NN
cord-006860-a3b8hyyr	1424	14	,	,	,
cord-006860-a3b8hyyr	1424	15	we	-PRON-	PRP
cord-006860-a3b8hyyr	1424	16	sensitized	sensitize	VBD
cord-006860-a3b8hyyr	1424	17	them	-PRON-	PRP
cord-006860-a3b8hyyr	1424	18	by	by	IN
cord-006860-a3b8hyyr	1424	19	simultaneous	simultaneous	JJ
cord-006860-a3b8hyyr	1424	20	treatment	treatment	NN
cord-006860-a3b8hyyr	1424	21	with	with	IN
cord-006860-a3b8hyyr	1424	22	D	d	NN
cord-006860-a3b8hyyr	1424	23	-	-	HYPH
cord-006860-a3b8hyyr	1424	24	galactosamlne	galactosamlne	NN
cord-006860-a3b8hyyr	1424	25	.	.	.
cord-006860-a3b8hyyr	1425	1	The	the	DT
cord-006860-a3b8hyyr	1425	2	80	80	CD
cord-006860-a3b8hyyr	1425	3	%	%	NN
cord-006860-a3b8hyyr	1425	4	lethality	lethality	NN
cord-006860-a3b8hyyr	1425	5	induced	induce	VBN
cord-006860-a3b8hyyr	1425	6	by	by	IN
cord-006860-a3b8hyyr	1425	7	LPS	LPS	NNP
cord-006860-a3b8hyyr	1425	8	(	(	-LRB-
cord-006860-a3b8hyyr	1425	9	1.5	1.5	CD
cord-006860-a3b8hyyr	1425	10	mg	mg	NN
cord-006860-a3b8hyyr	1425	11	/	/	SYM
cord-006860-a3b8hyyr	1425	12	mouse	mouse	NN
cord-006860-a3b8hyyr	1425	13	)	)	-RRB-
cord-006860-a3b8hyyr	1425	14	plus	plus	CC
cord-006860-a3b8hyyr	1425	15	D	D	NNP
cord-006860-a3b8hyyr	1425	16	-	-	HYPH
cord-006860-a3b8hyyr	1425	17	galactosamine	galactosamine	NNP
cord-006860-a3b8hyyr	1425	18	(	(	-LRB-
cord-006860-a3b8hyyr	1425	19	8	8	CD
cord-006860-a3b8hyyr	1425	20	mg	mg	NN
cord-006860-a3b8hyyr	1425	21	/	/	SYM
cord-006860-a3b8hyyr	1425	22	mouse	mouse	NN
cord-006860-a3b8hyyr	1425	23	)	)	-RRB-
cord-006860-a3b8hyyr	1425	24	in	in	IN
cord-006860-a3b8hyyr	1425	25	C3HS	C3HS	NNP
cord-006860-a3b8hyyr	1425	26	-	-	HYPH
cord-006860-a3b8hyyr	1425	27	Ie	Ie	NNP
cord-006860-a3b8hyyr	1425	28	mice	mouse	NNS
cord-006860-a3b8hyyr	1425	29	was	be	VBD
cord-006860-a3b8hyyr	1425	30	reduced	reduce	VBN
cord-006860-a3b8hyyr	1425	31	to	to	IN
cord-006860-a3b8hyyr	1425	32	16	16	CD
cord-006860-a3b8hyyr	1425	33	%	%	NN
cord-006860-a3b8hyyr	1425	34	by	by	IN
cord-006860-a3b8hyyr	1425	35	simultaneous	simultaneous	JJ
cord-006860-a3b8hyyr	1425	36	administration	administration	NN
cord-006860-a3b8hyyr	1425	37	of	of	IN
cord-006860-a3b8hyyr	1425	38	NG	NG	NNP
cord-006860-a3b8hyyr	1425	39	-	-	HYPH
cord-006860-a3b8hyyr	1425	40	R1	R1	NNP
cord-006860-a3b8hyyr	1425	41	(	(	-LRB-
cord-006860-a3b8hyyr	1425	42	1.5	1.5	CD
cord-006860-a3b8hyyr	1425	43	mg	mg	NN
cord-006860-a3b8hyyr	1425	44	/	/	SYM
cord-006860-a3b8hyyr	1425	45	mouse	mouse	NN
cord-006860-a3b8hyyr	1425	46	)	)	-RRB-
cord-006860-a3b8hyyr	1425	47	with	with	IN
cord-006860-a3b8hyyr	1425	48	LPS	LPS	NNP
cord-006860-a3b8hyyr	1425	49	/	/	SYM
cord-006860-a3b8hyyr	1425	50	galactosamine	galactosamine	NN
cord-006860-a3b8hyyr	1425	51	(	(	-LRB-
cord-006860-a3b8hyyr	1425	52	P<0.05	P<0.05	NNP
cord-006860-a3b8hyyr	1425	53	by	by	IN
cord-006860-a3b8hyyr	1425	54	X	x	NN
cord-006860-a3b8hyyr	1425	55	2	2	CD
cord-006860-a3b8hyyr	1425	56	test	test	NN
cord-006860-a3b8hyyr	1425	57	)	)	-RRB-
cord-006860-a3b8hyyr	1425	58	.	.	.
cord-006860-a3b8hyyr	1426	1	NG	NG	NNP
cord-006860-a3b8hyyr	1426	2	-	-	HYPH
cord-006860-a3b8hyyr	1426	3	R1	R1	NNP
cord-006860-a3b8hyyr	1426	4	also	also	RB
cord-006860-a3b8hyyr	1426	5	significantly	significantly	RB
cord-006860-a3b8hyyr	1426	6	delayed	delay	VBD
cord-006860-a3b8hyyr	1426	7	LPS	LPS	NNP
cord-006860-a3b8hyyr	1426	8	/	/	SYM
cord-006860-a3b8hyyr	1426	9	galactosamine	galactosamine	NN
cord-006860-a3b8hyyr	1426	10	induced	induce	VBN
cord-006860-a3b8hyyr	1426	11	lethal	lethal	JJ
cord-006860-a3b8hyyr	1426	12	toxicity	toxicity	NN
cord-006860-a3b8hyyr	1426	13	from	from	IN
cord-006860-a3b8hyyr	1426	14	12	12	CD
cord-006860-a3b8hyyr	1426	15	hours	hour	NNS
cord-006860-a3b8hyyr	1426	16	to	to	IN
cord-006860-a3b8hyyr	1426	17	30	30	CD
cord-006860-a3b8hyyr	1426	18	hours	hour	NNS
cord-006860-a3b8hyyr	1426	19	with	with	IN
cord-006860-a3b8hyyr	1426	20	all	all	DT
cord-006860-a3b8hyyr	1426	21	animals	animal	NNS
cord-006860-a3b8hyyr	1426	22	surviving	survive	VBG
cord-006860-a3b8hyyr	1426	23	beyond	beyond	IN
cord-006860-a3b8hyyr	1426	24	30	30	CD
cord-006860-a3b8hyyr	1426	25	hours	hour	NNS
cord-006860-a3b8hyyr	1426	26	.	.	.
cord-006860-a3b8hyyr	1427	1	Because	because	IN
cord-006860-a3b8hyyr	1427	2	lethality	lethality	NN
cord-006860-a3b8hyyr	1427	3	induced	induce	VBN
cord-006860-a3b8hyyr	1427	4	by	by	IN
cord-006860-a3b8hyyr	1427	5	LPS	LPS	NNP
cord-006860-a3b8hyyr	1427	6	involves	involve	VBZ
cord-006860-a3b8hyyr	1427	7	the	the	DT
cord-006860-a3b8hyyr	1427	8	synergistic	synergistic	JJ
cord-006860-a3b8hyyr	1427	9	effect	effect	NN
cord-006860-a3b8hyyr	1427	10	of	of	IN
cord-006860-a3b8hyyr	1427	11	multiple	multiple	JJ
cord-006860-a3b8hyyr	1427	12	effector	effector	NN
cord-006860-a3b8hyyr	1427	13	molecules	molecule	NNS
cord-006860-a3b8hyyr	1427	14	such	such	JJ
cord-006860-a3b8hyyr	1427	15	as	as	IN
cord-006860-a3b8hyyr	1427	16	tumor	tumor	NN
cord-006860-a3b8hyyr	1427	17	necrosis	necrosis	NN
cord-006860-a3b8hyyr	1427	18	factor	factor	NN
cord-006860-a3b8hyyr	1427	19	(	(	-LRB-
cord-006860-a3b8hyyr	1427	20	TNF)-ct	tnf)-ct	NN
cord-006860-a3b8hyyr	1427	21	,	,	,
cord-006860-a3b8hyyr	1427	22	interleukin	interleukin	FW
cord-006860-a3b8hyyr	1427	23	(	(	-LRB-
cord-006860-a3b8hyyr	1427	24	IL)-I	IL)-I	NNP
cord-006860-a3b8hyyr	1427	25	,	,	,
cord-006860-a3b8hyyr	1427	26	interferon	interferon	NN
cord-006860-a3b8hyyr	1427	27	3	3	CD
cord-006860-a3b8hyyr	1427	28	'	'	''
cord-006860-a3b8hyyr	1427	29	etc	etc	FW
cord-006860-a3b8hyyr	1427	30	.	.	.
cord-006860-a3b8hyyr	1428	1	,	,	,
cord-006860-a3b8hyyr	1428	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	1428	3	also	also	RB
cord-006860-a3b8hyyr	1428	4	investigated	investigate	VBD
cord-006860-a3b8hyyr	1428	5	the	the	DT
cord-006860-a3b8hyyr	1428	6	effect	effect	NN
cord-006860-a3b8hyyr	1428	7	of	of	IN
cord-006860-a3b8hyyr	1428	8	NG	NG	NNP
cord-006860-a3b8hyyr	1428	9	-	-	HYPH
cord-006860-a3b8hyyr	1428	10	R1	R1	NNP
cord-006860-a3b8hyyr	1428	11	on	on	IN
cord-006860-a3b8hyyr	1428	12	LPS	LPS	NNP
cord-006860-a3b8hyyr	1428	13	induced	induce	VBN
cord-006860-a3b8hyyr	1428	14	TNF	TNF	NNP
cord-006860-a3b8hyyr	1428	15	-	-	HYPH
cord-006860-a3b8hyyr	1428	16	ct	ct	NN
cord-006860-a3b8hyyr	1428	17	production	production	NN
cord-006860-a3b8hyyr	1428	18	from	from	IN
cord-006860-a3b8hyyr	1428	19	leukocytes	leukocyte	NNS
cord-006860-a3b8hyyr	1428	20	in	in	IN
cord-006860-a3b8hyyr	1428	21	cultured	cultured	JJ
cord-006860-a3b8hyyr	1428	22	human	human	JJ
cord-006860-a3b8hyyr	1428	23	whole	whole	JJ
cord-006860-a3b8hyyr	1428	24	blood	blood	NN
cord-006860-a3b8hyyr	1428	25	cells	cell	NNS
cord-006860-a3b8hyyr	1428	26	(	(	-LRB-
cord-006860-a3b8hyyr	1428	27	HWBCs	hwbc	NNS
cord-006860-a3b8hyyr	1428	28	)	)	-RRB-
cord-006860-a3b8hyyr	1428	29	ex	ex	NN
cord-006860-a3b8hyyr	1428	30	vivo	vivo	NN
cord-006860-a3b8hyyr	1428	31	.	.	.
cord-006860-a3b8hyyr	1429	1	The	the	DT
cord-006860-a3b8hyyr	1429	2	production	production	NN
cord-006860-a3b8hyyr	1429	3	of	of	IN
cord-006860-a3b8hyyr	1429	4	TNF	TNF	NNP
cord-006860-a3b8hyyr	1429	5	--	--	:
cord-006860-a3b8hyyr	1429	6	ct	ct	NNP
cord-006860-a3b8hyyr	1429	7	induced	induce	VBN
cord-006860-a3b8hyyr	1429	8	by	by	IN
cord-006860-a3b8hyyr	1429	9	LPS	LPS	NNP
cord-006860-a3b8hyyr	1429	10	(	(	-LRB-
cord-006860-a3b8hyyr	1429	11	1	1	CD
cord-006860-a3b8hyyr	1429	12	ng	ng	NN
cord-006860-a3b8hyyr	1429	13	/	/	SYM
cord-006860-a3b8hyyr	1429	14	mL	ml	NN
cord-006860-a3b8hyyr	1429	15	for	for	IN
cord-006860-a3b8hyyr	1429	16	24	24	CD
cord-006860-a3b8hyyr	1429	17	hours	hour	NNS
cord-006860-a3b8hyyr	1429	18	)	)	-RRB-
cord-006860-a3b8hyyr	1429	19	in	in	IN
cord-006860-a3b8hyyr	1429	20	the	the	DT
cord-006860-a3b8hyyr	1429	21	supernatant	supernatant	NN
cord-006860-a3b8hyyr	1429	22	of	of	IN
cord-006860-a3b8hyyr	1429	23	HWBCs	hwbc	NNS
cord-006860-a3b8hyyr	1429	24	was	be	VBD
cord-006860-a3b8hyyr	1429	25	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	1429	26	by	by	IN
cord-006860-a3b8hyyr	1429	27	46	46	CD
cord-006860-a3b8hyyr	1429	28	%	%	NN
cord-006860-a3b8hyyr	1429	29	and	and	CC
cord-006860-a3b8hyyr	1429	30	22	22	CD
cord-006860-a3b8hyyr	1429	31	%	%	NN
cord-006860-a3b8hyyr	1429	32	respectively	respectively	RB
cord-006860-a3b8hyyr	1429	33	,	,	,
cord-006860-a3b8hyyr	1429	34	when	when	WRB
cord-006860-a3b8hyyr	1429	35	the	the	DT
cord-006860-a3b8hyyr	1429	36	cells	cell	NNS
cord-006860-a3b8hyyr	1429	37	were	be	VBD
cord-006860-a3b8hyyr	1429	38	incubated	incubate	VBN
cord-006860-a3b8hyyr	1429	39	1	1	CD
cord-006860-a3b8hyyr	1429	40	ng	ng	NN
cord-006860-a3b8hyyr	1429	41	/	/	SYM
cord-006860-a3b8hyyr	1429	42	mL	ml	NN
cord-006860-a3b8hyyr	1429	43	or	or	CC
cord-006860-a3b8hyyr	1429	44	10	10	CD
cord-006860-a3b8hyyr	1429	45	ng	ng	NN
cord-006860-a3b8hyyr	1429	46	/	/	SYM
cord-006860-a3b8hyyr	1429	47	mL	ml	NN
cord-006860-a3b8hyyr	1429	48	LPS	lp	NNS
cord-006860-a3b8hyyr	1429	49	together	together	RB
cord-006860-a3b8hyyr	1429	50	with	with	IN
cord-006860-a3b8hyyr	1429	51	100	100	CD
cord-006860-a3b8hyyr	1429	52	I	i	NN
cord-006860-a3b8hyyr	1429	53	~	~	CD
cord-006860-a3b8hyyr	1429	54	g	g	NN
cord-006860-a3b8hyyr	1429	55	/	/	SYM
cord-006860-a3b8hyyr	1429	56	mL	mL	NNP
cord-006860-a3b8hyyr	1429	57	NG	NG	NNP
cord-006860-a3b8hyyr	1429	58	-	-	HYPH
cord-006860-a3b8hyyr	1429	59	R1	R1	NNP
cord-006860-a3b8hyyr	1429	60	,	,	,
cord-006860-a3b8hyyr	1429	61	respectively	respectively	RB
cord-006860-a3b8hyyr	1429	62	(	(	-LRB-
cord-006860-a3b8hyyr	1429	63	TNF	TNF	NNP
cord-006860-a3b8hyyr	1429	64	-	-	HYPH
cord-006860-a3b8hyyr	1429	65	ct	ct	NNP
cord-006860-a3b8hyyr	1429	66	concentration	concentration	NN
cord-006860-a3b8hyyr	1429	67	,	,	,
cord-006860-a3b8hyyr	1430	1	1	1	CD
cord-006860-a3b8hyyr	1430	2	ng	ng	NNP
cord-006860-a3b8hyyr	1430	3	/	/	SYM
cord-006860-a3b8hyyr	1430	4	mL	ml	NN
cord-006860-a3b8hyyr	1430	5	LPS	lp	NNS
cord-006860-a3b8hyyr	1430	6	treated	treat	VBD
cord-006860-a3b8hyyr	1430	7	cells	cell	NNS
cord-006860-a3b8hyyr	1430	8	:	:	:
cord-006860-a3b8hyyr	1430	9	297	297	CD
cord-006860-a3b8hyyr	1430	10	+	+	SYM
cord-006860-a3b8hyyr	1430	11	192	192	CD
cord-006860-a3b8hyyr	1430	12	pg	pg	NN
cord-006860-a3b8hyyr	1430	13	/	/	SYM
cord-006860-a3b8hyyr	1430	14	mL	ml	NN
cord-006860-a3b8hyyr	1430	15	,	,	,
cord-006860-a3b8hyyr	1431	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	1431	2	ng	ng	NNP
cord-006860-a3b8hyyr	1431	3	/	/	SYM
cord-006860-a3b8hyyr	1431	4	mL	mL	NNP
cord-006860-a3b8hyyr	1431	5	LPS	LPS	NNP
cord-006860-a3b8hyyr	1431	6	plus	plus	CC
cord-006860-a3b8hyyr	1431	7	100	100	CD
cord-006860-a3b8hyyr	1431	8	l.tg/mL	l.tg/ml	JJ
cord-006860-a3b8hyyr	1431	9	NG	NG	NNP
cord-006860-a3b8hyyr	1431	10	-	-	HYPH
cord-006860-a3b8hyyr	1431	11	RI	RI	NNP
cord-006860-a3b8hyyr	1431	12	treated	treat	VBN
cord-006860-a3b8hyyr	1431	13	cells	cell	NNS
cord-006860-a3b8hyyr	1431	14	:	:	:
cord-006860-a3b8hyyr	1431	15	162	162	CD
cord-006860-a3b8hyyr	1431	16	+	+	SYM
cord-006860-a3b8hyyr	1431	17	137	137	CD
cord-006860-a3b8hyyr	1431	18	pg	pg	NN
cord-006860-a3b8hyyr	1431	19	/	/	SYM
cord-006860-a3b8hyyr	1431	20	mL	ml	NN
cord-006860-a3b8hyyr	1431	21	,	,	,
cord-006860-a3b8hyyr	1431	22	P<0.01	P<0.01	NNS
cord-006860-a3b8hyyr	1431	23	;	;	.
cord-006860-a3b8hyyr	1432	1	10	10	CD
cord-006860-a3b8hyyr	1432	2	ng	ng	NN
cord-006860-a3b8hyyr	1432	3	/	/	SYM
cord-006860-a3b8hyyr	1432	4	mL	ml	NN
cord-006860-a3b8hyyr	1432	5	LPS	lp	NNS
cord-006860-a3b8hyyr	1432	6	treated	treat	VBD
cord-006860-a3b8hyyr	1432	7	cells	cell	NNS
cord-006860-a3b8hyyr	1432	8	:	:	:
cord-006860-a3b8hyyr	1432	9	3094_+487	3094_+487	CD
cord-006860-a3b8hyyr	1432	10	pg	pg	NNP
cord-006860-a3b8hyyr	1432	11	/	/	SYM
cord-006860-a3b8hyyr	1432	12	mL	mL	NNP
cord-006860-a3b8hyyr	1432	13	,	,	,
cord-006860-a3b8hyyr	1432	14	10	10	CD
cord-006860-a3b8hyyr	1432	15	ng	ng	NN
cord-006860-a3b8hyyr	1432	16	/	/	SYM
cord-006860-a3b8hyyr	1432	17	mL	ml	NN
cord-006860-a3b8hyyr	1432	18	LPS	lp	NNS
cord-006860-a3b8hyyr	1432	19	plus	plus	RB
cord-006860-a3b8hyyr	1433	1	100	100	CD
cord-006860-a3b8hyyr	1433	2	pg	pg	NN
cord-006860-a3b8hyyr	1433	3	/	/	SYM
cord-006860-a3b8hyyr	1433	4	mL	mL	NNP
cord-006860-a3b8hyyr	1433	5	NG	NG	NNP
cord-006860-a3b8hyyr	1433	6	-	-	HYPH
cord-006860-a3b8hyyr	1433	7	R1	R1	NNP
cord-006860-a3b8hyyr	1433	8	treated	treat	VBD
cord-006860-a3b8hyyr	1433	9	cells	cell	NNS
cord-006860-a3b8hyyr	1433	10	2423	2423	CD
cord-006860-a3b8hyyr	1433	11	+	+	SYM
cord-006860-a3b8hyyr	1433	12	713	713	CD
cord-006860-a3b8hyyr	1433	13	pg	pg	NN
cord-006860-a3b8hyyr	1433	14	/	/	SYM
cord-006860-a3b8hyyr	1433	15	mL	mL	NNP
cord-006860-a3b8hyyr	1433	16	,	,	,
cord-006860-a3b8hyyr	1433	17	/'=-0.02	/'=-0.02	NNP
cord-006860-a3b8hyyr	1433	18	)	)	-RRB-
cord-006860-a3b8hyyr	1433	19	.	.	.
cord-006860-a3b8hyyr	1434	1	The	the	DT
cord-006860-a3b8hyyr	1434	2	present	present	JJ
cord-006860-a3b8hyyr	1434	3	results	result	NNS
cord-006860-a3b8hyyr	1434	4	suggest	suggest	VBP
cord-006860-a3b8hyyr	1434	5	that	that	IN
cord-006860-a3b8hyyr	1434	6	NG	NG	NNP
cord-006860-a3b8hyyr	1434	7	-	-	HYPH
cord-006860-a3b8hyyr	1434	8	R1	R1	NNP
cord-006860-a3b8hyyr	1434	9	can	can	MD
cord-006860-a3b8hyyr	1434	10	prevent	prevent	VB
cord-006860-a3b8hyyr	1434	11	the	the	DT
cord-006860-a3b8hyyr	1434	12	onset	onset	NN
cord-006860-a3b8hyyr	1434	13	of	of	IN
cord-006860-a3b8hyyr	1434	14	LPS	LPS	NNP
cord-006860-a3b8hyyr	1434	15	toxicity	toxicity	NN
cord-006860-a3b8hyyr	1434	16	as	as	RB
cord-006860-a3b8hyyr	1434	17	well	well	RB
cord-006860-a3b8hyyr	1434	18	as	as	IN
cord-006860-a3b8hyyr	1434	19	the	the	DT
cord-006860-a3b8hyyr	1434	20	LPS	LPS	NNP
cord-006860-a3b8hyyr	1434	21	induction	induction	NN
cord-006860-a3b8hyyr	1434	22	of	of	IN
cord-006860-a3b8hyyr	1434	23	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	1434	24	.	.	.
cord-006860-a3b8hyyr	1435	1	Therefor	therefor	IN
cord-006860-a3b8hyyr	1435	2	NG	NG	NNP
cord-006860-a3b8hyyr	1435	3	-	-	HYPH
cord-006860-a3b8hyyr	1435	4	RI	RI	NNP
cord-006860-a3b8hyyr	1435	5	may	may	MD
cord-006860-a3b8hyyr	1435	6	be	be	VB
cord-006860-a3b8hyyr	1435	7	effective	effective	JJ
cord-006860-a3b8hyyr	1435	8	in	in	IN
cord-006860-a3b8hyyr	1435	9	preventing	prevent	VBG
cord-006860-a3b8hyyr	1435	10	the	the	DT
cord-006860-a3b8hyyr	1435	11	effects	effect	NNS
cord-006860-a3b8hyyr	1435	12	of	of	IN
cord-006860-a3b8hyyr	1435	13	septic	septic	JJ
cord-006860-a3b8hyyr	1435	14	shock	shock	NN
cord-006860-a3b8hyyr	1435	15	in	in	IN
cord-006860-a3b8hyyr	1435	16	Gram	gram	NN
cord-006860-a3b8hyyr	1435	17	-	-	HYPH
cord-006860-a3b8hyyr	1435	18	negative	negative	JJ
cord-006860-a3b8hyyr	1435	19	infections	infection	NNS
cord-006860-a3b8hyyr	1435	20	.	.	.
cord-006860-a3b8hyyr	1436	1	To	to	TO
cord-006860-a3b8hyyr	1436	2	elucidate	elucidate	VB
cord-006860-a3b8hyyr	1436	3	the	the	DT
cord-006860-a3b8hyyr	1436	4	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	1436	5	by	by	IN
cord-006860-a3b8hyyr	1436	6	which	which	WDT
cord-006860-a3b8hyyr	1436	7	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1436	8	is	be	VBZ
cord-006860-a3b8hyyr	1436	9	initiated	initiate	VBN
cord-006860-a3b8hyyr	1436	10	in	in	IN
cord-006860-a3b8hyyr	1436	11	septic	septic	JJ
cord-006860-a3b8hyyr	1436	12	patients	patient	NNS
cord-006860-a3b8hyyr	1436	13	in	in	IN
cord-006860-a3b8hyyr	1436	14	vivo	vivo	NN
cord-006860-a3b8hyyr	1436	15	,	,	,
cord-006860-a3b8hyyr	1436	16	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1436	17	measurements	measurement	NNS
cord-006860-a3b8hyyr	1436	18	were	be	VBD
cord-006860-a3b8hyyr	1436	19	prospectively	prospectively	RB
cord-006860-a3b8hyyr	1436	20	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	1436	21	in	in	IN
cord-006860-a3b8hyyr	1436	22	patients	patient	NNS
cord-006860-a3b8hyyr	1436	23	with	with	IN
cord-006860-a3b8hyyr	1436	24	severe	severe	JJ
cord-006860-a3b8hyyr	1436	25	chemotherapyinduced	chemotherapyinduced	JJ
cord-006860-a3b8hyyr	1436	26	neutropenia	neutropenia	NN
cord-006860-a3b8hyyr	1436	27	.	.	.
cord-006860-a3b8hyyr	1437	1	This	this	DT
cord-006860-a3b8hyyr	1437	2	group	group	NN
cord-006860-a3b8hyyr	1437	3	of	of	IN
cord-006860-a3b8hyyr	1437	4	patients	patient	NNS
cord-006860-a3b8hyyr	1437	5	was	be	VBD
cord-006860-a3b8hyyr	1437	6	chosen	choose	VBN
cord-006860-a3b8hyyr	1437	7	because	because	IN
cord-006860-a3b8hyyr	1437	8	of	of	IN
cord-006860-a3b8hyyr	1437	9	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1437	10	high	high	JJ
cord-006860-a3b8hyyr	1437	11	risk	risk	NN
cord-006860-a3b8hyyr	1437	12	of	of	IN
cord-006860-a3b8hyyr	1437	13	developing	develop	VBG
cord-006860-a3b8hyyr	1437	14	severe	severe	JJ
cord-006860-a3b8hyyr	1437	15	septic	septic	JJ
cord-006860-a3b8hyyr	1437	16	complications	complication	NNS
cord-006860-a3b8hyyr	1437	17	,	,	,
cord-006860-a3b8hyyr	1437	18	thus	thus	RB
cord-006860-a3b8hyyr	1437	19	allowing	allow	VBG
cord-006860-a3b8hyyr	1437	20	serial	serial	JJ
cord-006860-a3b8hyyr	1437	21	prospective	prospective	JJ
cord-006860-a3b8hyyr	1437	22	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1437	23	testing	testing	NN
cord-006860-a3b8hyyr	1437	24	prior	prior	RB
cord-006860-a3b8hyyr	1437	25	to	to	IN
cord-006860-a3b8hyyr	1437	26	and	and	CC
cord-006860-a3b8hyyr	1437	27	during	during	IN
cord-006860-a3b8hyyr	1437	28	evolving	evolve	VBG
cord-006860-a3b8hyyr	1437	29	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1437	30	or	or	CC
cord-006860-a3b8hyyr	1437	31	septic	septic	JJ
cord-006860-a3b8hyyr	1437	32	shock	shock	NN
cord-006860-a3b8hyyr	1437	33	.	.	.
cord-006860-a3b8hyyr	1438	1	62	62	CD
cord-006860-a3b8hyyr	1438	2	patients	patient	NNS
cord-006860-a3b8hyyr	1438	3	with	with	IN
cord-006860-a3b8hyyr	1438	4	febrile	febrile	JJ
cord-006860-a3b8hyyr	1438	5	infectious	infectious	JJ
cord-006860-a3b8hyyr	1438	6	events	event	NNS
cord-006860-a3b8hyyr	1438	7	were	be	VBD
cord-006860-a3b8hyyr	1438	8	accrued	accrue	VBN
cord-006860-a3b8hyyr	1438	9	to	to	IN
cord-006860-a3b8hyyr	1438	10	the	the	DT
cord-006860-a3b8hyyr	1438	11	study	study	NN
cord-006860-a3b8hyyr	1438	12	.	.	.
cord-006860-a3b8hyyr	1439	1	Of	of	IN
cord-006860-a3b8hyyr	1439	2	these	these	DT
cord-006860-a3b8hyyr	1439	3	,	,	,
cord-006860-a3b8hyyr	1439	4	13	13	CD
cord-006860-a3b8hyyr	1439	5	patients	patient	NNS
cord-006860-a3b8hyyr	1439	6	progressed	progress	VBD
cord-006860-a3b8hyyr	1439	7	to	to	IN
cord-006860-a3b8hyyr	1439	8	severe	severe	JJ
cord-006860-a3b8hyyr	1439	9	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1439	10	and	and	CC
cord-006860-a3b8hyyr	1439	11	an	an	DT
cord-006860-a3b8hyyr	1439	12	additional	additional	JJ
cord-006860-a3b8hyyr	1439	13	13	13	CD
cord-006860-a3b8hyyr	1439	14	patients	patient	NNS
cord-006860-a3b8hyyr	1439	15	to	to	TO
cord-006860-a3b8hyyr	1439	16	septic	septic	JJ
cord-006860-a3b8hyyr	1439	17	shock	shock	NN
cord-006860-a3b8hyyr	1439	18	.	.	.
cord-006860-a3b8hyyr	1440	1	At	at	IN
cord-006860-a3b8hyyr	1440	2	onset	onset	NN
cord-006860-a3b8hyyr	1440	3	of	of	IN
cord-006860-a3b8hyyr	1440	4	fever	fever	NN
cord-006860-a3b8hyyr	1440	5	,	,	,
cord-006860-a3b8hyyr	1440	6	Factor	factor	NN
cord-006860-a3b8hyyr	1440	7	(	(	-LRB-
cord-006860-a3b8hyyr	1440	8	F	F	NNP
cord-006860-a3b8hyyr	1440	9	)	)	-RRB-
cord-006860-a3b8hyyr	1440	10	Vlla	vlla	NN
cord-006860-a3b8hyyr	1440	11	activity	activity	NN
cord-006860-a3b8hyyr	1440	12	,	,	,
cord-006860-a3b8hyyr	1440	13	F	F	NNP
cord-006860-a3b8hyyr	1440	14	VII	VII	NNP
cord-006860-a3b8hyyr	1440	15	antigen	antigen	NN
cord-006860-a3b8hyyr	1440	16	and	and	CC
cord-006860-a3b8hyyr	1440	17	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	1440	18	III	iii	CD
cord-006860-a3b8hyyr	1441	1	(	(	-LRB-
cord-006860-a3b8hyyr	1441	2	AT	at	IN
cord-006860-a3b8hyyr	1441	3	III	III	NNP
cord-006860-a3b8hyyr	1441	4	)	)	-RRB-
cord-006860-a3b8hyyr	1441	5	activity	activity	NN
cord-006860-a3b8hyyr	1441	6	decreased	decrease	VBD
cord-006860-a3b8hyyr	1441	7	from	from	IN
cord-006860-a3b8hyyr	1441	8	normal	normal	JJ
cord-006860-a3b8hyyr	1441	9	baseline	baseline	NN
cord-006860-a3b8hyyr	1441	10	revels	revel	NNS
cord-006860-a3b8hyyr	1441	11	and	and	CC
cord-006860-a3b8hyyr	1441	12	were	be	VBD
cord-006860-a3b8hyyr	1441	13	significantly	significantly	RB
cord-006860-a3b8hyyr	1441	14	lower	low	JJR
cord-006860-a3b8hyyr	1441	15	in	in	IN
cord-006860-a3b8hyyr	1441	16	the	the	DT
cord-006860-a3b8hyyr	1441	17	group	group	NN
cord-006860-a3b8hyyr	1441	18	of	of	IN
cord-006860-a3b8hyyr	1441	19	patients	patient	NNS
cord-006860-a3b8hyyr	1441	20	who	who	WP
cord-006860-a3b8hyyr	1441	21	progressed	progress	VBD
cord-006860-a3b8hyyr	1441	22	to	to	TO
cord-006860-a3b8hyyr	1441	23	septic	septic	JJ
cord-006860-a3b8hyyr	1441	24	shock	shock	NN
cord-006860-a3b8hyyr	1441	25	compared	compare	VBN
cord-006860-a3b8hyyr	1441	26	to	to	IN
cord-006860-a3b8hyyr	1441	27	those	those	DT
cord-006860-a3b8hyyr	1441	28	that	that	WDT
cord-006860-a3b8hyyr	1441	29	developed	develop	VBD
cord-006860-a3b8hyyr	1441	30	severe	severe	JJ
cord-006860-a3b8hyyr	1441	31	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1442	1	(	(	-LRB-
cord-006860-a3b8hyyr	1442	2	medians	median	NNS
cord-006860-a3b8hyyr	1442	3	:	:	:
cord-006860-a3b8hyyr	1442	4	0.3	0.3	CD
cord-006860-a3b8hyyr	1442	5	versus	versus	IN
cord-006860-a3b8hyyr	1442	6	1.4	1.4	CD
cord-006860-a3b8hyyr	1442	7	ng	ng	NNP
cord-006860-a3b8hyyr	1442	8	/	/	SYM
cord-006860-a3b8hyyr	1442	9	ml	ml	NN
cord-006860-a3b8hyyr	1442	10	,	,	,
cord-006860-a3b8hyyr	1442	11	21	21	CD
cord-006860-a3b8hyyr	1442	12	versus	versus	IN
cord-006860-a3b8hyyr	1442	13	86	86	CD
cord-006860-a3b8hyyr	1442	14	U	U	NNP
cord-006860-a3b8hyyr	1442	15	/	/	SYM
cord-006860-a3b8hyyr	1442	16	dl	dl	NN
cord-006860-a3b8hyyr	1442	17	and	and	CC
cord-006860-a3b8hyyr	1442	18	45	45	CD
cord-006860-a3b8hyyr	1442	19	versus	versus	IN
cord-006860-a3b8hyyr	1442	20	95	95	CD
cord-006860-a3b8hyyr	1442	21	%	%	NN
cord-006860-a3b8hyyr	1442	22	;	;	:
cord-006860-a3b8hyyr	1442	23	P	p	NN
cord-006860-a3b8hyyr	1442	24	<	<	XX
cord-006860-a3b8hyyr	1442	25	0.001	0.001	CD
cord-006860-a3b8hyyr	1442	26	)	)	-RRB-
cord-006860-a3b8hyyr	1442	27	.	.	.
cord-006860-a3b8hyyr	1443	1	The	the	DT
cord-006860-a3b8hyyr	1443	2	decrease	decrease	NN
cord-006860-a3b8hyyr	1443	3	of	of	IN
cord-006860-a3b8hyyr	1443	4	these	these	DT
cord-006860-a3b8hyyr	1443	5	variables	variable	NNS
cord-006860-a3b8hyyr	1443	6	in	in	IN
cord-006860-a3b8hyyr	1443	7	septic	septic	JJ
cord-006860-a3b8hyyr	1443	8	shock	shock	NN
cord-006860-a3b8hyyr	1443	9	was	be	VBD
cord-006860-a3b8hyyr	1443	10	accompanied	accompany	VBN
cord-006860-a3b8hyyr	1443	11	by	by	IN
cord-006860-a3b8hyyr	1443	12	an	an	DT
cord-006860-a3b8hyyr	1443	13	increase	increase	NN
cord-006860-a3b8hyyr	1443	14	in	in	IN
cord-006860-a3b8hyyr	1443	15	a	a	DT
cord-006860-a3b8hyyr	1443	16	marker	marker	NN
cord-006860-a3b8hyyr	1443	17	of	of	IN
cord-006860-a3b8hyyr	1443	18	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1443	19	generation	generation	NN
cord-006860-a3b8hyyr	1443	20	like	like	IN
cord-006860-a3b8hyyr	1443	21	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	1443	22	fragment	fragment	NN
cord-006860-a3b8hyyr	1443	23	1	1	CD
cord-006860-a3b8hyyr	1444	1	+	+	SYM
cord-006860-a3b8hyyr	1444	2	2	2	CD
cord-006860-a3b8hyyr	1444	3	(	(	-LRB-
cord-006860-a3b8hyyr	1444	4	medians	median	NNS
cord-006860-a3b8hyyr	1444	5	:	:	:
cord-006860-a3b8hyyr	1444	6	3.6	3.6	CD
cord-006860-a3b8hyyr	1444	7	versus	versus	IN
cord-006860-a3b8hyyr	1444	8	1.4	1.4	CD
cord-006860-a3b8hyyr	1444	9	riM	rim	CD
cord-006860-a3b8hyyr	1444	10	;	;	:
cord-006860-a3b8hyyr	1444	11	P	p	NN
cord-006860-a3b8hyyr	1444	12	=	=	SYM
cord-006860-a3b8hyyr	1444	13	O.05	o.05	NN
cord-006860-a3b8hyyr	1444	14	)	)	-RRB-
cord-006860-a3b8hyyr	1444	15	.	.	.
cord-006860-a3b8hyyr	1445	1	These	these	DT
cord-006860-a3b8hyyr	1445	2	differences	difference	NNS
cord-006860-a3b8hyyr	1445	3	were	be	VBD
cord-006860-a3b8hyyr	1445	4	sustained	sustain	VBN
cord-006860-a3b8hyyr	1445	5	throughout	throughout	IN
cord-006860-a3b8hyyr	1445	6	the	the	DT
cord-006860-a3b8hyyr	1445	7	septic	septic	JJ
cord-006860-a3b8hyyr	1445	8	episode	episode	NN
cord-006860-a3b8hyyr	1445	9	(	(	-LRB-
cord-006860-a3b8hyyr	1445	10	P	p	NN
cord-006860-a3b8hyyr	1445	11	<	<	XX
cord-006860-a3b8hyyr	1445	12	0.0001	0.0001	CD
cord-006860-a3b8hyyr	1445	13	)	)	-RRB-
cord-006860-a3b8hyyr	1445	14	.	.	.
cord-006860-a3b8hyyr	1446	1	F	F	NNP
cord-006860-a3b8hyyr	1446	2	Vlla	Vlla	NNP
cord-006860-a3b8hyyr	1446	3	and	and	CC
cord-006860-a3b8hyyr	1446	4	AT	at	IN
cord-006860-a3b8hyyr	1446	5	Ill	Ill	NNP
cord-006860-a3b8hyyr	1446	6	levels	level	NNS
cord-006860-a3b8hyyr	1446	7	of	of	IN
cord-006860-a3b8hyyr	1446	8	<	<	XX
cord-006860-a3b8hyyr	1446	9	0.8	0.8	CD
cord-006860-a3b8hyyr	1446	10	ng	ng	NNP
cord-006860-a3b8hyyr	1446	11	/	/	SYM
cord-006860-a3b8hyyr	1446	12	ml	ml	NN
cord-006860-a3b8hyyr	1446	13	and	and	CC
cord-006860-a3b8hyyr	1446	14	<	<	XX
cord-006860-a3b8hyyr	1446	15	70	70	CD
cord-006860-a3b8hyyr	1446	16	%	%	NN
cord-006860-a3b8hyyr	1446	17	,	,	,
cord-006860-a3b8hyyr	1446	18	respectively	respectively	RB
cord-006860-a3b8hyyr	1446	19	,	,	,
cord-006860-a3b8hyyr	1446	20	at	at	IN
cord-006860-a3b8hyyr	1446	21	onset	onset	NN
cord-006860-a3b8hyyr	1446	22	of	of	IN
cord-006860-a3b8hyyr	1446	23	fever	fever	NN
cord-006860-a3b8hyyr	1446	24	predicted	predict	VBD
cord-006860-a3b8hyyr	1446	25	a	a	DT
cord-006860-a3b8hyyr	1446	26	lethal	lethal	JJ
cord-006860-a3b8hyyr	1446	27	outcome	outcome	NN
cord-006860-a3b8hyyr	1446	28	with	with	IN
cord-006860-a3b8hyyr	1446	29	a	a	DT
cord-006860-a3b8hyyr	1446	30	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	1446	31	of	of	IN
cord-006860-a3b8hyyr	1446	32	100	100	CD
cord-006860-a3b8hyyr	1446	33	and	and	CC
cord-006860-a3b8hyyr	1446	34	85	85	CD
cord-006860-a3b8hyyr	1446	35	%	%	NN
cord-006860-a3b8hyyr	1446	36	,	,	,
cord-006860-a3b8hyyr	1446	37	and	and	CC
cord-006860-a3b8hyyr	1446	38	a	a	DT
cord-006860-a3b8hyyr	1446	39	specificity	specificity	NN
cord-006860-a3b8hyyr	1446	40	of	of	IN
cord-006860-a3b8hyyr	1446	41	75	75	CD
cord-006860-a3b8hyyr	1446	42	and	and	CC
cord-006860-a3b8hyyr	1446	43	85	85	CD
cord-006860-a3b8hyyr	1446	44	%	%	NN
cord-006860-a3b8hyyr	1446	45	,	,	,
cord-006860-a3b8hyyr	1446	46	respectively	respectively	RB
cord-006860-a3b8hyyr	1446	47	.	.	.
cord-006860-a3b8hyyr	1447	1	In	in	IN
cord-006860-a3b8hyyr	1447	2	contrast	contrast	NN
cord-006860-a3b8hyyr	1447	3	,	,	,
cord-006860-a3b8hyyr	1447	4	FXIla	fxila	JJ
cord-006860-a3b8hyyr	1447	5	-	-	HYPH
cord-006860-a3b8hyyr	1447	6	alpha	alpha	NN
cord-006860-a3b8hyyr	1447	7	antigen	antigen	NN
cord-006860-a3b8hyyr	1447	8	levels	level	NNS
cord-006860-a3b8hyyr	1447	9	were	be	VBD
cord-006860-a3b8hyyr	1447	10	not	not	RB
cord-006860-a3b8hyyr	1447	11	different	different	JJ
cord-006860-a3b8hyyr	1447	12	between	between	IN
cord-006860-a3b8hyyr	1447	13	both	both	DT
cord-006860-a3b8hyyr	1447	14	groups	group	NNS
cord-006860-a3b8hyyr	1447	15	at	at	IN
cord-006860-a3b8hyyr	1447	16	onset	onset	NN
cord-006860-a3b8hyyr	1447	17	of	of	IN
cord-006860-a3b8hyyr	1447	18	fever	fever	NN
cord-006860-a3b8hyyr	1447	19	and	and	CC
cord-006860-a3b8hyyr	1447	20	were	be	VBD
cord-006860-a3b8hyyr	1447	21	only	only	RB
cord-006860-a3b8hyyr	1447	22	marginally	marginally	RB
cord-006860-a3b8hyyr	1447	23	higher	higher	RBR
cord-006860-a3b8hyyr	1447	24	further	further	RB
cord-006860-a3b8hyyr	1447	25	during	during	IN
cord-006860-a3b8hyyr	1447	26	the	the	DT
cord-006860-a3b8hyyr	1447	27	course	course	NN
cord-006860-a3b8hyyr	1447	28	of	of	IN
cord-006860-a3b8hyyr	1447	29	septic	septic	JJ
cord-006860-a3b8hyyr	1447	30	shock	shock	NN
cord-006860-a3b8hyyr	1447	31	(	(	-LRB-
cord-006860-a3b8hyyr	1447	32	P	p	NN
cord-006860-a3b8hyyr	1447	33	=	=	SYM
cord-006860-a3b8hyyr	1447	34	O.001	O.001	NNP
cord-006860-a3b8hyyr	1447	35	)	)	-RRB-
cord-006860-a3b8hyyr	1447	36	.	.	.
cord-006860-a3b8hyyr	1448	1	Thus	thus	RB
cord-006860-a3b8hyyr	1448	2	,	,	,
cord-006860-a3b8hyyr	1448	3	septic	septic	JJ
cord-006860-a3b8hyyr	1448	4	shock	shock	NN
cord-006860-a3b8hyyr	1448	5	in	in	IN
cord-006860-a3b8hyyr	1448	6	neutropenia	neutropenia	NN
cord-006860-a3b8hyyr	1448	7	is	be	VBZ
cord-006860-a3b8hyyr	1448	8	associated	associate	VBN
cord-006860-a3b8hyyr	1448	9	with	with	IN
cord-006860-a3b8hyyr	1448	10	significant	significant	JJ
cord-006860-a3b8hyyr	1448	11	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1448	12	activation	activation	NN
cord-006860-a3b8hyyr	1448	13	,	,	,
cord-006860-a3b8hyyr	1448	14	presumably	presumably	RB
cord-006860-a3b8hyyr	1448	15	driven	drive	VBN
cord-006860-a3b8hyyr	1448	16	by	by	IN
cord-006860-a3b8hyyr	1448	17	the	the	DT
cord-006860-a3b8hyyr	1448	18	tissue	tissue	NN
cord-006860-a3b8hyyr	1448	19	factor	factor	NN
cord-006860-a3b8hyyr	1448	20	pathway	pathway	NN
cord-006860-a3b8hyyr	1448	21	rather	rather	RB
cord-006860-a3b8hyyr	1448	22	than	than	IN
cord-006860-a3b8hyyr	1448	23	the	the	DT
cord-006860-a3b8hyyr	1448	24	contact	contact	NN
cord-006860-a3b8hyyr	1448	25	system	system	NN
cord-006860-a3b8hyyr	1448	26	.	.	.
cord-006860-a3b8hyyr	1449	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	1449	2	,	,	,
cord-006860-a3b8hyyr	1449	3	in	in	IN
cord-006860-a3b8hyyr	1449	4	septicemia	septicemia	NN
cord-006860-a3b8hyyr	1449	5	both	both	CC
cord-006860-a3b8hyyr	1449	6	F	F	NNP
cord-006860-a3b8hyyr	1449	7	Vlla	Vlla	NNP
cord-006860-a3b8hyyr	1449	8	and	and	CC
cord-006860-a3b8hyyr	1449	9	AT	AT	NNP
cord-006860-a3b8hyyr	1449	10	III	iii	CD
cord-006860-a3b8hyyr	1449	11	measurements	measurement	NNS
cord-006860-a3b8hyyr	1449	12	are	be	VBP
cord-006860-a3b8hyyr	1449	13	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	1449	14	markers	marker	NNS
cord-006860-a3b8hyyr	1449	15	of	of	IN
cord-006860-a3b8hyyr	1449	16	an	an	DT
cord-006860-a3b8hyyr	1449	17	unfavourable	unfavourable	JJ
cord-006860-a3b8hyyr	1449	18	prognosis	prognosis	NN
cord-006860-a3b8hyyr	1449	19	.	.	.
cord-006860-a3b8hyyr	1450	1	Hemostatic	hemostatic	NN
cord-006860-a3b8hyyr	1450	2	parameters	parameter	NNS
cord-006860-a3b8hyyr	1450	3	in	in	IN
cord-006860-a3b8hyyr	1450	4	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1450	5	patients	patient	NNS
cord-006860-a3b8hyyr	1450	6	treated	treat	VBN
cord-006860-a3b8hyyr	1450	7	with	with	IN
cord-006860-a3b8hyyr	1450	8	anti	anti	JJ
cord-006860-a3b8hyyr	1450	9	-	-	JJ
cord-006860-a3b8hyyr	1450	10	TNFct	tnfct	JJ
cord-006860-a3b8hyyr	1450	11	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	1450	12	antibodies	antibody	NNS
cord-006860-a3b8hyyr	1450	13	C.	C.	NNP
cord-006860-a3b8hyyr	1450	14	Salat	Salat	NNP
cord-006860-a3b8hyyr	1450	15	1	1	CD
cord-006860-a3b8hyyr	1450	16	,	,	,
cord-006860-a3b8hyyr	1450	17	P.	P.	NNP
cord-006860-a3b8hyyr	1450	18	Boekstegers	Boekstegers	NNP
cord-006860-a3b8hyyr	1450	19	2	2	CD
cord-006860-a3b8hyyr	1450	20	,	,	,
cord-006860-a3b8hyyr	1450	21	E.	E.	NNP
cord-006860-a3b8hyyr	1450	22	Holler	Holler	NNP
cord-006860-a3b8hyyr	1450	23	1,3	1,3	NNP
cord-006860-a3b8hyyr	1450	24	,	,	,
cord-006860-a3b8hyyr	1450	25	B.	B.	NNP
cord-006860-a3b8hyyr	1450	26	Reinhardt	Reinhardt	NNP
cord-006860-a3b8hyyr	1450	27	I	I	NNP
cord-006860-a3b8hyyr	1450	28	,	,	,
cord-006860-a3b8hyyr	1450	29	R.	R.	NNP
cord-006860-a3b8hyyr	1450	30	Pihusch	Pihusch	NNP
cord-006860-a3b8hyyr	1450	31	1	1	CD
cord-006860-a3b8hyyr	1450	32	,	,	,
cord-006860-a3b8hyyr	1450	33	K.	K.	NNP
cord-006860-a3b8hyyr	1450	34	Werdan	Werdan	NNP
cord-006860-a3b8hyyr	1450	35	2	2	CD
cord-006860-a3b8hyyr	1450	36	,	,	,
cord-006860-a3b8hyyr	1450	37	M.	M.	NNP
cord-006860-a3b8hyyr	1450	38	Kaul	Kaul	NNP
cord-006860-a3b8hyyr	1450	39	4	4	CD
cord-006860-a3b8hyyr	1450	40	,	,	,
cord-006860-a3b8hyyr	1450	41	T.	T.	NNP
cord-006860-a3b8hyyr	1450	42	Beinert	Beinert	NNP
cord-006860-a3b8hyyr	1450	43	2	2	CD
cord-006860-a3b8hyyr	1450	44	,	,	,
cord-006860-a3b8hyyr	1450	45	E.	E.	NNP
cord-006860-a3b8hyyr	1450	46	Hiller	Hiller	NNP
cord-006860-a3b8hyyr	1450	47	1	1	CD
cord-006860-a3b8hyyr	1450	48	Med	Med	NNP
cord-006860-a3b8hyyr	1450	49	.	.	.
cord-006860-a3b8hyyr	1450	50	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	1450	51	III	III	NNP
cord-006860-a3b8hyyr	1450	52	1	1	CD
cord-006860-a3b8hyyr	1451	1	und	und	NNP
cord-006860-a3b8hyyr	1452	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	1452	2	2	2	CD
cord-006860-a3b8hyyr	1452	3	,	,	,
cord-006860-a3b8hyyr	1452	4	Klinikum	Klinikum	NNP
cord-006860-a3b8hyyr	1452	5	Grosshadern	Grosshadern	NNP
cord-006860-a3b8hyyr	1452	6	der	der	NNP
cord-006860-a3b8hyyr	1452	7	Ludwig	Ludwig	NNP
cord-006860-a3b8hyyr	1452	8	-	-	HYPH
cord-006860-a3b8hyyr	1452	9	Maximilians	Maximilians	NNP
cord-006860-a3b8hyyr	1452	10	-	-	HYPH
cord-006860-a3b8hyyr	1452	11	Universitat	Universitat	NNP
cord-006860-a3b8hyyr	1453	1	MOnchen	MOnchen	NNP
cord-006860-a3b8hyyr	1453	2	,	,	,
cord-006860-a3b8hyyr	1453	3	H	H	NNP
cord-006860-a3b8hyyr	1453	4	~	~	NFP
cord-006860-a3b8hyyr	1453	5	imatologikum	imatologikum	NNP
cord-006860-a3b8hyyr	1453	6	der	der	NNP
cord-006860-a3b8hyyr	1453	7	GSF	GSF	NNP
cord-006860-a3b8hyyr	1453	8	3	3	CD
cord-006860-a3b8hyyr	1453	9	,	,	,
cord-006860-a3b8hyyr	1453	10	Knoll	Knoll	NNP
cord-006860-a3b8hyyr	1453	11	AG	AG	NNP
cord-006860-a3b8hyyr	1453	12	Ludwigshafen	Ludwigshafen	NNP
cord-006860-a3b8hyyr	1453	13	4	4	CD
cord-006860-a3b8hyyr	1453	14	Tumor	tumor	NN
cord-006860-a3b8hyyr	1453	15	necrosis	necrosis	NN
cord-006860-a3b8hyyr	1453	16	factor	factor	NN
cord-006860-a3b8hyyr	1454	1	et	et	NNP
cord-006860-a3b8hyyr	1455	1	(	(	-LRB-
cord-006860-a3b8hyyr	1455	2	TNFc~	TNFc~	NNP
cord-006860-a3b8hyyr	1455	3	)	)	-RRB-
cord-006860-a3b8hyyr	1455	4	is	be	VBZ
cord-006860-a3b8hyyr	1455	5	a	a	DT
cord-006860-a3b8hyyr	1455	6	central	central	JJ
cord-006860-a3b8hyyr	1455	7	mediator	mediator	NN
cord-006860-a3b8hyyr	1455	8	in	in	IN
cord-006860-a3b8hyyr	1455	9	the	the	DT
cord-006860-a3b8hyyr	1455	10	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	1455	11	of	of	IN
cord-006860-a3b8hyyr	1455	12	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1455	13	and	and	CC
cord-006860-a3b8hyyr	1455	14	septic	septic	JJ
cord-006860-a3b8hyyr	1455	15	shock	shock	NN
cord-006860-a3b8hyyr	1455	16	.	.	.
cord-006860-a3b8hyyr	1456	1	As	as	IN
cord-006860-a3b8hyyr	1456	2	administration	administration	NN
cord-006860-a3b8hyyr	1456	3	of	of	IN
cord-006860-a3b8hyyr	1456	4	anti	anti	JJ
cord-006860-a3b8hyyr	1456	5	-	-	JJ
cord-006860-a3b8hyyr	1456	6	TNFct	tnfct	JJ
cord-006860-a3b8hyyr	1456	7	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	1456	8	antibodies	antibody	NNS
cord-006860-a3b8hyyr	1456	9	was	be	VBD
cord-006860-a3b8hyyr	1456	10	able	able	JJ
cord-006860-a3b8hyyr	1456	11	to	to	TO
cord-006860-a3b8hyyr	1456	12	protect	protect	VB
cord-006860-a3b8hyyr	1456	13	animals	animal	NNS
cord-006860-a3b8hyyr	1456	14	from	from	IN
cord-006860-a3b8hyyr	1456	15	an	an	DT
cord-006860-a3b8hyyr	1456	16	otherwise	otherwise	RB
cord-006860-a3b8hyyr	1456	17	lethal	lethal	JJ
cord-006860-a3b8hyyr	1456	18	endotoxin	endotoxin	NN
cord-006860-a3b8hyyr	1456	19	challenge	challenge	NN
cord-006860-a3b8hyyr	1456	20	clinical	clinical	JJ
cord-006860-a3b8hyyr	1456	21	studies	study	NNS
cord-006860-a3b8hyyr	1456	22	were	be	VBD
cord-006860-a3b8hyyr	1456	23	initiated	initiate	VBN
cord-006860-a3b8hyyr	1456	24	in	in	IN
cord-006860-a3b8hyyr	1456	25	patients	patient	NNS
cord-006860-a3b8hyyr	1456	26	with	with	IN
cord-006860-a3b8hyyr	1456	27	sepis	sepis	NN
cord-006860-a3b8hyyr	1456	28	.	.	.
cord-006860-a3b8hyyr	1457	1	TNFct	TNFct	NNP
cord-006860-a3b8hyyr	1457	2	exerts	exert	VBZ
cord-006860-a3b8hyyr	1457	3	a	a	DT
cord-006860-a3b8hyyr	1457	4	procoagulant	procoagulant	JJ
cord-006860-a3b8hyyr	1457	5	effect	effect	NN
cord-006860-a3b8hyyr	1457	6	,	,	,
cord-006860-a3b8hyyr	1457	7	e.g.	e.g.	RB
cord-006860-a3b8hyyr	1457	8	by	by	IN
cord-006860-a3b8hyyr	1457	9	enhancing	enhance	VBG
cord-006860-a3b8hyyr	1457	10	PAI	PAI	NNP
cord-006860-a3b8hyyr	1457	11	-	-	HYPH
cord-006860-a3b8hyyr	1457	12	I	I	NNP
cord-006860-a3b8hyyr	1457	13	and	and	CC
cord-006860-a3b8hyyr	1457	14	activating	activate	VBG
cord-006860-a3b8hyyr	1457	15	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1457	16	as	as	IN
cord-006860-a3b8hyyr	1457	17	indicated	indicate	VBN
cord-006860-a3b8hyyr	1457	18	by	by	IN
cord-006860-a3b8hyyr	1457	19	an	an	DT
cord-006860-a3b8hyyr	1457	20	increase	increase	NN
cord-006860-a3b8hyyr	1457	21	in	in	IN
cord-006860-a3b8hyyr	1457	22	TAT	TAT	NNP
cord-006860-a3b8hyyr	1457	23	and	and	CC
cord-006860-a3b8hyyr	1457	24	PF	PF	NNP
cord-006860-a3b8hyyr	1457	25	1/2	1/2	CD
cord-006860-a3b8hyyr	1457	26	levels	level	NNS
cord-006860-a3b8hyyr	1457	27	.	.	.
cord-006860-a3b8hyyr	1458	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	1458	2	it	-PRON-	PRP
cord-006860-a3b8hyyr	1458	3	may	may	MD
cord-006860-a3b8hyyr	1458	4	be	be	VB
cord-006860-a3b8hyyr	1458	5	involved	involve	VBN
cord-006860-a3b8hyyr	1458	6	in	in	IN
cord-006860-a3b8hyyr	1458	7	disseminated	disseminate	VBN
cord-006860-a3b8hyyr	1458	8	intravascular	intravascular	JJ
cord-006860-a3b8hyyr	1458	9	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1458	10	in	in	IN
cord-006860-a3b8hyyr	1458	11	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1458	12	.	.	.
cord-006860-a3b8hyyr	1459	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1459	2	determined	determine	VBD
cord-006860-a3b8hyyr	1459	3	TAT	TAT	NNP
cord-006860-a3b8hyyr	1459	4	,	,	,
cord-006860-a3b8hyyr	1459	5	PF	PF	NNP
cord-006860-a3b8hyyr	1459	6	1/2	1/2	CD
cord-006860-a3b8hyyr	1459	7	,	,	,
cord-006860-a3b8hyyr	1459	8	D	d	NN
cord-006860-a3b8hyyr	1459	9	-	-	HYPH
cord-006860-a3b8hyyr	1459	10	dimers	dimer	NNS
cord-006860-a3b8hyyr	1459	11	,	,	,
cord-006860-a3b8hyyr	1459	12	tPA	tPA	NNP
cord-006860-a3b8hyyr	1459	13	,	,	,
cord-006860-a3b8hyyr	1459	14	uPA	uPA	NNP
cord-006860-a3b8hyyr	1459	15	,	,	,
cord-006860-a3b8hyyr	1459	16	PAI	PAI	NNP
cord-006860-a3b8hyyr	1459	17	-	-	HYPH
cord-006860-a3b8hyyr	1459	18	I	I	NNP
cord-006860-a3b8hyyr	1459	19	and	and	CC
cord-006860-a3b8hyyr	1459	20	vWF	vwf	NN
cord-006860-a3b8hyyr	1459	21	levels	level	NNS
cord-006860-a3b8hyyr	1459	22	in	in	IN
cord-006860-a3b8hyyr	1459	23	30	30	CD
cord-006860-a3b8hyyr	1459	24	patients	patient	NNS
cord-006860-a3b8hyyr	1459	25	with	with	IN
cord-006860-a3b8hyyr	1459	26	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1459	27	or	or	CC
cord-006860-a3b8hyyr	1459	28	septic	septic	JJ
cord-006860-a3b8hyyr	1459	29	shock	shock	NN
cord-006860-a3b8hyyr	1459	30	.	.	.
cord-006860-a3b8hyyr	1460	1	14	14	CD
cord-006860-a3b8hyyr	1460	2	patients	patient	NNS
cord-006860-a3b8hyyr	1460	3	received	receive	VBD
cord-006860-a3b8hyyr	1460	4	the	the	DT
cord-006860-a3b8hyyr	1460	5	anti	anti	NNP
cord-006860-a3b8hyyr	1460	6	-	-	JJ
cord-006860-a3b8hyyr	1460	7	TNFa	tnfa	JJ
cord-006860-a3b8hyyr	1460	8	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	1460	9	antibody	antibody	NN
cord-006860-a3b8hyyr	1460	10	MAK	MAK	NNP
cord-006860-a3b8hyyr	1460	11	195F	195f	CD
cord-006860-a3b8hyyr	1461	1	(	(	-LRB-
cord-006860-a3b8hyyr	1461	2	Knoll	Knoll	NNP
cord-006860-a3b8hyyr	1461	3	AG	AG	NNP
cord-006860-a3b8hyyr	1461	4	,	,	,
cord-006860-a3b8hyyr	1461	5	Ludwigshafen	Ludwigshafen	NNP
cord-006860-a3b8hyyr	1461	6	)	)	-RRB-
cord-006860-a3b8hyyr	1461	7	,	,	,
cord-006860-a3b8hyyr	1461	8	whereas	whereas	IN
cord-006860-a3b8hyyr	1461	9	16	16	CD
cord-006860-a3b8hyyr	1461	10	patients	patient	NNS
cord-006860-a3b8hyyr	1461	11	served	serve	VBD
cord-006860-a3b8hyyr	1461	12	as	as	IN
cord-006860-a3b8hyyr	1461	13	controls	control	NNS
cord-006860-a3b8hyyr	1461	14	.	.	.
cord-006860-a3b8hyyr	1462	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1462	2	found	find	VBD
cord-006860-a3b8hyyr	1462	3	a	a	DT
cord-006860-a3b8hyyr	1462	4	significantly	significantly	RB
cord-006860-a3b8hyyr	1462	5	lower	low	JJR
cord-006860-a3b8hyyr	1462	6	level	level	NN
cord-006860-a3b8hyyr	1462	7	ofuPA	ofupa	XX
cord-006860-a3b8hyyr	1462	8	in	in	IN
cord-006860-a3b8hyyr	1462	9	anti	anti	JJ
cord-006860-a3b8hyyr	1462	10	-	-	JJ
cord-006860-a3b8hyyr	1462	11	TNFc~	TNFc~	NNP
cord-006860-a3b8hyyr	1462	12	treated	treat	VBN
cord-006860-a3b8hyyr	1462	13	patients	patient	NNS
cord-006860-a3b8hyyr	1462	14	.	.	.
cord-006860-a3b8hyyr	1463	1	Since	since	IN
cord-006860-a3b8hyyr	1463	2	the	the	DT
cord-006860-a3b8hyyr	1463	3	difference	difference	NN
cord-006860-a3b8hyyr	1463	4	existed	exist	VBD
cord-006860-a3b8hyyr	1463	5	before	before	IN
cord-006860-a3b8hyyr	1463	6	onset	onset	NN
cord-006860-a3b8hyyr	1463	7	of	of	IN
cord-006860-a3b8hyyr	1463	8	treatment	treatment	NN
cord-006860-a3b8hyyr	1463	9	it	-PRON-	PRP
cord-006860-a3b8hyyr	1463	10	can	can	MD
cord-006860-a3b8hyyr	1463	11	not	not	RB
cord-006860-a3b8hyyr	1463	12	be	be	VB
cord-006860-a3b8hyyr	1463	13	attributed	attribute	VBN
cord-006860-a3b8hyyr	1463	14	to	to	IN
cord-006860-a3b8hyyr	1463	15	TNFot	TNFot	NNP
cord-006860-a3b8hyyr	1463	16	antagonisation	antagonisation	NN
cord-006860-a3b8hyyr	1463	17	.	.	.
cord-006860-a3b8hyyr	1464	1	All	all	DT
cord-006860-a3b8hyyr	1464	2	other	other	JJ
cord-006860-a3b8hyyr	1464	3	parameters	parameter	NNS
cord-006860-a3b8hyyr	1464	4	investigated	investigate	VBN
cord-006860-a3b8hyyr	1464	5	did	do	VBD
cord-006860-a3b8hyyr	1464	6	not	not	RB
cord-006860-a3b8hyyr	1464	7	differ	differ	VB
cord-006860-a3b8hyyr	1464	8	significantly	significantly	RB
cord-006860-a3b8hyyr	1464	9	between	between	IN
cord-006860-a3b8hyyr	1464	10	the	the	DT
cord-006860-a3b8hyyr	1464	11	two	two	CD
cord-006860-a3b8hyyr	1464	12	groups	group	NNS
cord-006860-a3b8hyyr	1464	13	throughout	throughout	IN
cord-006860-a3b8hyyr	1464	14	the	the	DT
cord-006860-a3b8hyyr	1464	15	study	study	NN
cord-006860-a3b8hyyr	1464	16	period	period	NN
cord-006860-a3b8hyyr	1464	17	.	.	.
cord-006860-a3b8hyyr	1465	1	Failure	failure	NN
cord-006860-a3b8hyyr	1465	2	to	to	TO
cord-006860-a3b8hyyr	1465	3	detect	detect	VB
cord-006860-a3b8hyyr	1465	4	modulation	modulation	NN
cord-006860-a3b8hyyr	1465	5	of	of	IN
cord-006860-a3b8hyyr	1465	6	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	1465	7	by	by	IN
cord-006860-a3b8hyyr	1465	8	anti	anti	NNS
cord-006860-a3b8hyyr	1465	9	-	-	NNS
cord-006860-a3b8hyyr	1465	10	TNF~	tnf~	JJ
cord-006860-a3b8hyyr	1465	11	might	may	MD
cord-006860-a3b8hyyr	1465	12	be	be	VB
cord-006860-a3b8hyyr	1465	13	explained	explain	VBN
cord-006860-a3b8hyyr	1465	14	by	by	IN
cord-006860-a3b8hyyr	1465	15	delayed	delay	VBN
cord-006860-a3b8hyyr	1465	16	initiation	initiation	NN
cord-006860-a3b8hyyr	1465	17	of	of	IN
cord-006860-a3b8hyyr	1465	18	treatment	treatment	NN
cord-006860-a3b8hyyr	1465	19	in	in	IN
cord-006860-a3b8hyyr	1465	20	clinical	clinical	JJ
cord-006860-a3b8hyyr	1465	21	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1465	22	.	.	.
cord-006860-a3b8hyyr	1466	1	In	in	IN
cord-006860-a3b8hyyr	1466	2	animal	animal	NN
cord-006860-a3b8hyyr	1466	3	experiments	experiment	NNS
cord-006860-a3b8hyyr	1466	4	it	-PRON-	PRP
cord-006860-a3b8hyyr	1466	5	has	have	VBZ
cord-006860-a3b8hyyr	1466	6	been	be	VBN
cord-006860-a3b8hyyr	1466	7	observed	observe	VBN
cord-006860-a3b8hyyr	1466	8	that	that	IN
cord-006860-a3b8hyyr	1466	9	the	the	DT
cord-006860-a3b8hyyr	1466	10	antibody	antibody	NN
cord-006860-a3b8hyyr	1466	11	prevented	prevent	VBD
cord-006860-a3b8hyyr	1466	12	lethal	lethal	JJ
cord-006860-a3b8hyyr	1466	13	endotoxin	endotoxin	NN
cord-006860-a3b8hyyr	1466	14	effects	effect	NNS
cord-006860-a3b8hyyr	1466	15	when	when	WRB
cord-006860-a3b8hyyr	1466	16	given	give	VBN
cord-006860-a3b8hyyr	1466	17	prophylactically	prophylactically	RB
cord-006860-a3b8hyyr	1466	18	or	or	CC
cord-006860-a3b8hyyr	1466	19	30	30	CD
cord-006860-a3b8hyyr	1466	20	minutes	minute	NNS
cord-006860-a3b8hyyr	1466	21	after	after	IN
cord-006860-a3b8hyyr	1466	22	endotoxin	endotoxin	NN
cord-006860-a3b8hyyr	1466	23	challenge	challenge	NN
cord-006860-a3b8hyyr	1466	24	,	,	,
cord-006860-a3b8hyyr	1466	25	but	but	CC
cord-006860-a3b8hyyr	1466	26	not	not	RB
cord-006860-a3b8hyyr	1466	27	when	when	WRB
cord-006860-a3b8hyyr	1466	28	it	-PRON-	PRP
cord-006860-a3b8hyyr	1466	29	was	be	VBD
cord-006860-a3b8hyyr	1466	30	administered	administer	VBN
cord-006860-a3b8hyyr	1466	31	2.5	2.5	CD
cord-006860-a3b8hyyr	1466	32	hours	hour	NNS
cord-006860-a3b8hyyr	1466	33	later	later	RB
cord-006860-a3b8hyyr	1466	34	.	.	.
cord-006860-a3b8hyyr	1467	1	In	in	IN
cord-006860-a3b8hyyr	1467	2	addition	addition	NN
cord-006860-a3b8hyyr	1467	3	,	,	,
cord-006860-a3b8hyyr	1467	4	beneficial	beneficial	JJ
cord-006860-a3b8hyyr	1467	5	clinical	clinical	JJ
cord-006860-a3b8hyyr	1467	6	and	and	CC
cord-006860-a3b8hyyr	1467	7	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	1467	8	effects	effect	NNS
cord-006860-a3b8hyyr	1467	9	of	of	IN
cord-006860-a3b8hyyr	1467	10	TNFet	TNFet	NNP
cord-006860-a3b8hyyr	1467	11	antagonisation	antagonisation	NN
cord-006860-a3b8hyyr	1467	12	might	may	MD
cord-006860-a3b8hyyr	1467	13	be	be	VB
cord-006860-a3b8hyyr	1467	14	observed	observe	VBN
cord-006860-a3b8hyyr	1467	15	only	only	RB
cord-006860-a3b8hyyr	1467	16	in	in	IN
cord-006860-a3b8hyyr	1467	17	subgroups	subgroup	NNS
cord-006860-a3b8hyyr	1467	18	of	of	IN
cord-006860-a3b8hyyr	1467	19	patients	patient	NNS
cord-006860-a3b8hyyr	1467	20	with	with	IN
cord-006860-a3b8hyyr	1467	21	hyperinflammatory	hyperinflammatory	JJ
cord-006860-a3b8hyyr	1467	22	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1467	23	.	.	.
cord-006860-a3b8hyyr	1468	1	Larger	large	JJR
cord-006860-a3b8hyyr	1468	2	studies	study	NNS
cord-006860-a3b8hyyr	1468	3	addressing	address	VBG
cord-006860-a3b8hyyr	1468	4	this	this	DT
cord-006860-a3b8hyyr	1468	5	point	point	NN
cord-006860-a3b8hyyr	1468	6	are	be	VBP
cord-006860-a3b8hyyr	1468	7	under	under	IN
cord-006860-a3b8hyyr	1468	8	way	way	NN
cord-006860-a3b8hyyr	1468	9	.	.	.
cord-006860-a3b8hyyr	1469	1	Protease	protease	NN
cord-006860-a3b8hyyr	1469	2	receptors	receptor	NNS
cord-006860-a3b8hyyr	1469	3	for	for	IN
cord-006860-a3b8hyyr	1469	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1469	5	and	and	CC
cord-006860-a3b8hyyr	1469	6	trypsin	trypsin	NN
cord-006860-a3b8hyyr	1469	7	have	have	VBP
cord-006860-a3b8hyyr	1469	8	been	be	VBN
cord-006860-a3b8hyyr	1469	9	described	describe	VBN
cord-006860-a3b8hyyr	1469	10	for	for	IN
cord-006860-a3b8hyyr	1469	11	different	different	JJ
cord-006860-a3b8hyyr	1469	12	cell	cell	NN
cord-006860-a3b8hyyr	1469	13	lines	line	NNS
cord-006860-a3b8hyyr	1469	14	.	.	.
cord-006860-a3b8hyyr	1470	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1470	2	investigated	investigate	VBD
cord-006860-a3b8hyyr	1470	3	the	the	DT
cord-006860-a3b8hyyr	1470	4	ability	ability	NN
cord-006860-a3b8hyyr	1470	5	of	of	IN
cord-006860-a3b8hyyr	1470	6	trypsin	trypsin	NN
cord-006860-a3b8hyyr	1470	7	to	to	TO
cord-006860-a3b8hyyr	1470	8	activate	activate	VB
cord-006860-a3b8hyyr	1470	9	human	human	JJ
cord-006860-a3b8hyyr	1470	10	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	1470	11	vein	vein	NN
cord-006860-a3b8hyyr	1470	12	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1470	13	cells	cell	NNS
cord-006860-a3b8hyyr	1470	14	(	(	-LRB-
cord-006860-a3b8hyyr	1470	15	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	1470	16	)	)	-RRB-
cord-006860-a3b8hyyr	1470	17	.	.	.
cord-006860-a3b8hyyr	1471	1	Cell	cell	NN
cord-006860-a3b8hyyr	1471	2	activation	activation	NN
cord-006860-a3b8hyyr	1471	3	was	be	VBD
cord-006860-a3b8hyyr	1471	4	measured	measure	VBN
cord-006860-a3b8hyyr	1471	5	by	by	IN
cord-006860-a3b8hyyr	1471	6	the	the	DT
cord-006860-a3b8hyyr	1471	7	increase	increase	NN
cord-006860-a3b8hyyr	1471	8	of	of	IN
cord-006860-a3b8hyyr	1471	9	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	1471	10	free	free	JJ
cord-006860-a3b8hyyr	1472	1	Ca	ca	NN
cord-006860-a3b8hyyr	1472	2	2	2	CD
cord-006860-a3b8hyyr	1472	3	*	*	NFP
cord-006860-a3b8hyyr	1472	4	(	(	-LRB-
cord-006860-a3b8hyyr	1472	5	Caff	Caff	NNP
cord-006860-a3b8hyyr	1472	6	)	)	-RRB-
cord-006860-a3b8hyyr	1472	7	with	with	IN
cord-006860-a3b8hyyr	1472	8	help	help	NN
cord-006860-a3b8hyyr	1472	9	of	of	IN
cord-006860-a3b8hyyr	1472	10	microscope	microscope	NN
cord-006860-a3b8hyyr	1472	11	fiuorometry	fiuorometry	NN
cord-006860-a3b8hyyr	1472	12	(	(	-LRB-
cord-006860-a3b8hyyr	1472	13	FURA-2	FURA-2	NNP
cord-006860-a3b8hyyr	1472	14	)	)	-RRB-
cord-006860-a3b8hyyr	1472	15	and	and	CC
cord-006860-a3b8hyyr	1472	16	by	by	IN
cord-006860-a3b8hyyr	1472	17	the	the	DT
cord-006860-a3b8hyyr	1472	18	von	von	NNP
cord-006860-a3b8hyyr	1472	19	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	1472	20	factor	factor	NN
cord-006860-a3b8hyyr	1472	21	release	release	NN
cord-006860-a3b8hyyr	1472	22	measured	measure	VBN
cord-006860-a3b8hyyr	1472	23	by	by	IN
cord-006860-a3b8hyyr	1472	24	a	a	DT
cord-006860-a3b8hyyr	1472	25	sandwich	sandwich	NN
cord-006860-a3b8hyyr	1472	26	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	1472	27	.	.	.
cord-006860-a3b8hyyr	1473	1	Incubation	incubation	NN
cord-006860-a3b8hyyr	1473	2	of	of	IN
cord-006860-a3b8hyyr	1473	3	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	1473	4	with	with	IN
cord-006860-a3b8hyyr	1473	5	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1473	6	(	(	-LRB-
cord-006860-a3b8hyyr	1473	7	1U	1U	NNP
cord-006860-a3b8hyyr	1473	8	/	/	SYM
cord-006860-a3b8hyyr	1473	9	ml	ml	NN
cord-006860-a3b8hyyr	1473	10	)	)	-RRB-
cord-006860-a3b8hyyr	1473	11	or	or	CC
cord-006860-a3b8hyyr	1473	12	trypsin	trypsin	NN
cord-006860-a3b8hyyr	1473	13	(	(	-LRB-
cord-006860-a3b8hyyr	1473	14	10nM	10nm	CD
cord-006860-a3b8hyyr	1473	15	)	)	-RRB-
cord-006860-a3b8hyyr	1473	16	showed	show	VBD
cord-006860-a3b8hyyr	1473	17	a	a	DT
cord-006860-a3b8hyyr	1473	18	2	2	CD
cord-006860-a3b8hyyr	1473	19	-	-	SYM
cord-006860-a3b8hyyr	1473	20	10	10	CD
cord-006860-a3b8hyyr	1473	21	fold	fold	JJ
cord-006860-a3b8hyyr	1473	22	increase	increase	NN
cord-006860-a3b8hyyr	1473	23	of	of	IN
cord-006860-a3b8hyyr	1473	24	C	c	NN
cord-006860-a3b8hyyr	1473	25	~	~	CD
cord-006860-a3b8hyyr	1473	26	ff	ff	NN
cord-006860-a3b8hyyr	1473	27	.	.	.
cord-006860-a3b8hyyr	1474	1	A	a	DT
cord-006860-a3b8hyyr	1474	2	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	1474	3	homologous	homologous	JJ
cord-006860-a3b8hyyr	1474	4	stimulation	stimulation	NN
cord-006860-a3b8hyyr	1474	5	after	after	IN
cord-006860-a3b8hyyr	1474	6	80	80	CD
cord-006860-a3b8hyyr	1474	7	s	s	POS
cord-006860-a3b8hyyr	1474	8	lead	lead	NN
cord-006860-a3b8hyyr	1474	9	to	to	IN
cord-006860-a3b8hyyr	1474	10	a	a	DT
cord-006860-a3b8hyyr	1474	11	2	2	CD
cord-006860-a3b8hyyr	1474	12	-	-	SYM
cord-006860-a3b8hyyr	1474	13	5	5	CD
cord-006860-a3b8hyyr	1474	14	fold	fold	VB
cord-006860-a3b8hyyr	1474	15	lower	low	JJR
cord-006860-a3b8hyyr	1474	16	concentration	concentration	NN
cord-006860-a3b8hyyr	1474	17	of	of	IN
cord-006860-a3b8hyyr	1474	18	Ca~	Ca~	NNP
cord-006860-a3b8hyyr	1474	19	2÷	2÷	CD
cord-006860-a3b8hyyr	1474	20	compared	compare	VBN
cord-006860-a3b8hyyr	1474	21	to	to	IN
cord-006860-a3b8hyyr	1474	22	the	the	DT
cord-006860-a3b8hyyr	1474	23	first	first	JJ
cord-006860-a3b8hyyr	1474	24	stimulation	stimulation	NN
cord-006860-a3b8hyyr	1474	25	.	.	.
cord-006860-a3b8hyyr	1475	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	1475	2	cells	cell	NNS
cord-006860-a3b8hyyr	1475	3	have	have	VBP
cord-006860-a3b8hyyr	1475	4	been	be	VBN
cord-006860-a3b8hyyr	1475	5	desensitised	desensitise	VBN
cord-006860-a3b8hyyr	1475	6	by	by	IN
cord-006860-a3b8hyyr	1475	7	the	the	DT
cord-006860-a3b8hyyr	1475	8	first	first	JJ
cord-006860-a3b8hyyr	1475	9	stimulation	stimulation	NN
cord-006860-a3b8hyyr	1475	10	.	.	.
cord-006860-a3b8hyyr	1476	1	Inhibition	inhibition	NN
cord-006860-a3b8hyyr	1476	2	of	of	IN
cord-006860-a3b8hyyr	1476	3	the	the	DT
cord-006860-a3b8hyyr	1476	4	proteolytical	proteolytical	JJ
cord-006860-a3b8hyyr	1476	5	activity	activity	NN
cord-006860-a3b8hyyr	1476	6	of	of	IN
cord-006860-a3b8hyyr	1476	7	trypsin	trypsin	NN
cord-006860-a3b8hyyr	1476	8	by	by	IN
cord-006860-a3b8hyyr	1476	9	soybean	soybean	NN
cord-006860-a3b8hyyr	1476	10	trypsin	trypsin	NN
cord-006860-a3b8hyyr	1476	11	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	1476	12	was	be	VBD
cord-006860-a3b8hyyr	1476	13	followed	follow	VBN
cord-006860-a3b8hyyr	1476	14	by	by	IN
cord-006860-a3b8hyyr	1476	15	failure	failure	NN
cord-006860-a3b8hyyr	1476	16	of	of	IN
cord-006860-a3b8hyyr	1476	17	trypsin	trypsin	NN
cord-006860-a3b8hyyr	1476	18	inducing	induce	VBG
cord-006860-a3b8hyyr	1476	19	an	an	DT
cord-006860-a3b8hyyr	1476	20	increase	increase	NN
cord-006860-a3b8hyyr	1476	21	of	of	IN
cord-006860-a3b8hyyr	1476	22	Ca~	Ca~	NNP
cord-006860-a3b8hyyr	1476	23	2÷	2÷	CD
cord-006860-a3b8hyyr	1476	24	concentration	concentration	NN
cord-006860-a3b8hyyr	1476	25	.	.	.
cord-006860-a3b8hyyr	1477	1	In	in	IN
cord-006860-a3b8hyyr	1477	2	cross	cross	JJ
cord-006860-a3b8hyyr	1477	3	stimulation	stimulation	NN
cord-006860-a3b8hyyr	1477	4	experiments	experiment	NNS
cord-006860-a3b8hyyr	1477	5	with	with	IN
cord-006860-a3b8hyyr	1477	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1477	7	and	and	CC
cord-006860-a3b8hyyr	1477	8	trypsin	trypsin	NN
cord-006860-a3b8hyyr	1477	9	,	,	,
cord-006860-a3b8hyyr	1477	10	we	-PRON-	PRP
cord-006860-a3b8hyyr	1477	11	could	could	MD
cord-006860-a3b8hyyr	1477	12	demonstrate	demonstrate	VB
cord-006860-a3b8hyyr	1477	13	,	,	,
cord-006860-a3b8hyyr	1477	14	that	that	WDT
cord-006860-a3b8hyyr	1477	15	cells	cell	NNS
cord-006860-a3b8hyyr	1477	16	first	first	RB
cord-006860-a3b8hyyr	1477	17	stimulated	stimulate	VBD
cord-006860-a3b8hyyr	1477	18	with	with	IN
cord-006860-a3b8hyyr	1477	19	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1477	20	showed	show	VBD
cord-006860-a3b8hyyr	1477	21	a	a	DT
cord-006860-a3b8hyyr	1477	22	second	second	JJ
cord-006860-a3b8hyyr	1477	23	maximal	maximal	JJ
cord-006860-a3b8hyyr	1477	24	response	response	NN
cord-006860-a3b8hyyr	1477	25	by	by	IN
cord-006860-a3b8hyyr	1477	26	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	1477	27	stimulation	stimulation	NN
cord-006860-a3b8hyyr	1477	28	with	with	IN
cord-006860-a3b8hyyr	1477	29	trypsin	trypsin	NN
cord-006860-a3b8hyyr	1477	30	.	.	.
cord-006860-a3b8hyyr	1478	1	The	the	DT
cord-006860-a3b8hyyr	1478	2	same	same	JJ
cord-006860-a3b8hyyr	1478	3	effect	effect	NN
cord-006860-a3b8hyyr	1478	4	was	be	VBD
cord-006860-a3b8hyyr	1478	5	measured	measure	VBN
cord-006860-a3b8hyyr	1478	6	with	with	IN
cord-006860-a3b8hyyr	1478	7	first	first	JJ
cord-006860-a3b8hyyr	1478	8	stimulus	stimulus	NN
cord-006860-a3b8hyyr	1478	9	trypsin	trypsin	NN
cord-006860-a3b8hyyr	1478	10	and	and	CC
cord-006860-a3b8hyyr	1479	1	second	second	JJ
cord-006860-a3b8hyyr	1479	2	stimulus	stimulus	NN
cord-006860-a3b8hyyr	1479	3	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1479	4	.	.	.
cord-006860-a3b8hyyr	1480	1	Trypsin	Trypsin	NNP
cord-006860-a3b8hyyr	1480	2	and	and	CC
cord-006860-a3b8hyyr	1480	3	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1480	4	induced	induce	VBD
cord-006860-a3b8hyyr	1480	5	a	a	DT
cord-006860-a3b8hyyr	1480	6	release	release	NN
cord-006860-a3b8hyyr	1480	7	of	of	IN
cord-006860-a3b8hyyr	1480	8	von	von	NNP
cord-006860-a3b8hyyr	1480	9	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	1480	10	factor	factor	NN
cord-006860-a3b8hyyr	1480	11	(	(	-LRB-
cord-006860-a3b8hyyr	1480	12	2	2	CD
cord-006860-a3b8hyyr	1480	13	-	-	SYM
cord-006860-a3b8hyyr	1480	14	5	5	CD
cord-006860-a3b8hyyr	1480	15	fold	fold	NN
cord-006860-a3b8hyyr	1480	16	in	in	IN
cord-006860-a3b8hyyr	1480	17	comparison	comparison	NN
cord-006860-a3b8hyyr	1480	18	to	to	IN
cord-006860-a3b8hyyr	1480	19	unstimulated	unstimulated	JJ
cord-006860-a3b8hyyr	1480	20	cells	cell	NNS
cord-006860-a3b8hyyr	1480	21	)	)	-RRB-
cord-006860-a3b8hyyr	1480	22	.	.	.
cord-006860-a3b8hyyr	1481	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1481	2	found	find	VBD
cord-006860-a3b8hyyr	1481	3	a	a	DT
cord-006860-a3b8hyyr	1481	4	vWf	vwf	NN
cord-006860-a3b8hyyr	1481	5	release	release	NN
cord-006860-a3b8hyyr	1481	6	dependent	dependent	JJ
cord-006860-a3b8hyyr	1481	7	on	on	IN
cord-006860-a3b8hyyr	1481	8	the	the	DT
cord-006860-a3b8hyyr	1481	9	concentration	concentration	NN
cord-006860-a3b8hyyr	1481	10	of	of	IN
cord-006860-a3b8hyyr	1481	11	trypsin	trypsin	NN
cord-006860-a3b8hyyr	1481	12	similar	similar	JJ
cord-006860-a3b8hyyr	1481	13	to	to	IN
cord-006860-a3b8hyyr	1481	14	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1481	15	.	.	.
cord-006860-a3b8hyyr	1482	1	An	an	DT
cord-006860-a3b8hyyr	1482	2	electrophoretic	electrophoretic	JJ
cord-006860-a3b8hyyr	1482	3	analysis	analysis	NN
cord-006860-a3b8hyyr	1482	4	of	of	IN
cord-006860-a3b8hyyr	1482	5	the	the	DT
cord-006860-a3b8hyyr	1482	6	released	release	VBN
cord-006860-a3b8hyyr	1482	7	von	von	NNP
cord-006860-a3b8hyyr	1482	8	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	1482	9	factor	factor	NN
cord-006860-a3b8hyyr	1482	10	showed	show	VBD
cord-006860-a3b8hyyr	1482	11	a	a	DT
cord-006860-a3b8hyyr	1482	12	different	different	JJ
cord-006860-a3b8hyyr	1482	13	multimeric	multimeric	JJ
cord-006860-a3b8hyyr	1482	14	composition	composition	NN
cord-006860-a3b8hyyr	1482	15	of	of	IN
cord-006860-a3b8hyyr	1482	16	vWf	vWf	NNS
cord-006860-a3b8hyyr	1482	17	between	between	IN
cord-006860-a3b8hyyr	1482	18	trypsin	trypsin	NN
cord-006860-a3b8hyyr	1482	19	and	and	CC
cord-006860-a3b8hyyr	1482	20	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1482	21	stimulation	stimulation	NN
cord-006860-a3b8hyyr	1482	22	.	.	.
cord-006860-a3b8hyyr	1483	1	These	these	DT
cord-006860-a3b8hyyr	1483	2	results	result	NNS
cord-006860-a3b8hyyr	1483	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	1483	4	,	,	,
cord-006860-a3b8hyyr	1483	5	that	that	IN
cord-006860-a3b8hyyr	1483	6	there	there	EX
cord-006860-a3b8hyyr	1483	7	might	may	MD
cord-006860-a3b8hyyr	1483	8	be	be	VB
cord-006860-a3b8hyyr	1483	9	a	a	DT
cord-006860-a3b8hyyr	1483	10	protease	protease	NN
cord-006860-a3b8hyyr	1483	11	receptor	receptor	NN
cord-006860-a3b8hyyr	1483	12	on	on	IN
cord-006860-a3b8hyyr	1483	13	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	1483	14	for	for	IN
cord-006860-a3b8hyyr	1483	15	trypsin	trypsin	NN
cord-006860-a3b8hyyr	1483	16	being	be	VBG
cord-006860-a3b8hyyr	1483	17	different	different	JJ
cord-006860-a3b8hyyr	1483	18	from	from	IN
cord-006860-a3b8hyyr	1483	19	the	the	DT
cord-006860-a3b8hyyr	1483	20	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1483	21	receptor	receptor	NN
cord-006860-a3b8hyyr	1483	22	.	.	.
cord-006860-a3b8hyyr	1484	1	Clinical	clinical	JJ
cord-006860-a3b8hyyr	1484	2	and	and	CC
cord-006860-a3b8hyyr	1484	3	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1484	4	findings	finding	NNS
cord-006860-a3b8hyyr	1484	5	of	of	IN
cord-006860-a3b8hyyr	1484	6	coagulopathy	coagulopathy	NN
cord-006860-a3b8hyyr	1484	7	were	be	VBD
cord-006860-a3b8hyyr	1484	8	investigated	investigate	VBN
cord-006860-a3b8hyyr	1484	9	by	by	IN
cord-006860-a3b8hyyr	1484	10	an	an	DT
cord-006860-a3b8hyyr	1484	11	1-year	1-year	CD
cord-006860-a3b8hyyr	1484	12	-	-	HYPH
cord-006860-a3b8hyyr	1484	13	survey	survey	NN
cord-006860-a3b8hyyr	1484	14	to	to	IN
cord-006860-a3b8hyyr	1484	15	320	320	CD
cord-006860-a3b8hyyr	1484	16	children	child	NNS
cord-006860-a3b8hyyr	1484	17	's	's	POS
cord-006860-a3b8hyyr	1484	18	hospitals	hospital	NNS
cord-006860-a3b8hyyr	1484	19	.	.	.
cord-006860-a3b8hyyr	1485	1	291	291	CD
cord-006860-a3b8hyyr	1485	2	meningococcal	meningococcal	JJ
cord-006860-a3b8hyyr	1485	3	infections	infection	NNS
cord-006860-a3b8hyyr	1485	4	were	be	VBD
cord-006860-a3b8hyyr	1485	5	evaluable	evaluable	JJ
cord-006860-a3b8hyyr	1485	6	.	.	.
cord-006860-a3b8hyyr	1486	1	Severe	severe	JJ
cord-006860-a3b8hyyr	1486	2	disease	disease	NN
cord-006860-a3b8hyyr	1486	3	(	(	-LRB-
cord-006860-a3b8hyyr	1486	4	characterized	characterize	VBN
cord-006860-a3b8hyyr	1486	5	by	by	IN
cord-006860-a3b8hyyr	1486	6	need	need	NN
cord-006860-a3b8hyyr	1486	7	for	for	IN
cord-006860-a3b8hyyr	1486	8	mechanical	mechanical	JJ
cord-006860-a3b8hyyr	1486	9	ventilation	ventilation	NN
cord-006860-a3b8hyyr	1486	10	,	,	,
cord-006860-a3b8hyyr	1486	11	dialysis	dialysis	NN
cord-006860-a3b8hyyr	1486	12	and/or	and/or	CC
cord-006860-a3b8hyyr	1486	13	catecholamines	catecholamine	NNS
cord-006860-a3b8hyyr	1486	14	)	)	-RRB-
cord-006860-a3b8hyyr	1486	15	was	be	VBD
cord-006860-a3b8hyyr	1486	16	seen	see	VBN
cord-006860-a3b8hyyr	1486	17	in	in	IN
cord-006860-a3b8hyyr	1486	18	42	42	CD
cord-006860-a3b8hyyr	1486	19	of	of	IN
cord-006860-a3b8hyyr	1486	20	these	these	DT
cord-006860-a3b8hyyr	1486	21	children	child	NNS
cord-006860-a3b8hyyr	1486	22	;	;	:
cord-006860-a3b8hyyr	1486	23	29	29	CD
cord-006860-a3b8hyyr	1486	24	of	of	IN
cord-006860-a3b8hyyr	1486	25	those	those	DT
cord-006860-a3b8hyyr	1486	26	survived	survive	VBN
cord-006860-a3b8hyyr	1486	27	and	and	CC
cord-006860-a3b8hyyr	1486	28	13	13	CD
cord-006860-a3b8hyyr	1486	29	died	die	VBD
cord-006860-a3b8hyyr	1486	30	.	.	.
cord-006860-a3b8hyyr	1487	1	Clinical	clinical	JJ
cord-006860-a3b8hyyr	1487	2	signs	sign	NNS
cord-006860-a3b8hyyr	1487	3	of	of	IN
cord-006860-a3b8hyyr	1487	4	severe	severe	JJ
cord-006860-a3b8hyyr	1487	5	coagulopathy	coagulopathy	NN
cord-006860-a3b8hyyr	1487	6	were	be	VBD
cord-006860-a3b8hyyr	1487	7	seen	see	VBN
cord-006860-a3b8hyyr	1487	8	in	in	IN
cord-006860-a3b8hyyr	1487	9	83	83	CD
cord-006860-a3b8hyyr	1487	10	children	child	NNS
cord-006860-a3b8hyyr	1487	11	:	:	:
cord-006860-a3b8hyyr	1488	1	Ecchymoses	Ecchymoses	NNP
cord-006860-a3b8hyyr	1488	2	(	(	-LRB-
cord-006860-a3b8hyyr	1488	3	n	n	NN
cord-006860-a3b8hyyr	1488	4	=	=	SYM
cord-006860-a3b8hyyr	1488	5	73	73	CD
cord-006860-a3b8hyyr	1488	6	)	)	-RRB-
cord-006860-a3b8hyyr	1488	7	and	and	CC
cord-006860-a3b8hyyr	1488	8	skin	skin	NN
cord-006860-a3b8hyyr	1488	9	necrosis	necrosis	NN
cord-006860-a3b8hyyr	1489	1	(	(	-LRB-
cord-006860-a3b8hyyr	1489	2	n	n	NN
cord-006860-a3b8hyyr	1489	3	=	=	SYM
cord-006860-a3b8hyyr	1489	4	36	36	CD
cord-006860-a3b8hyyr	1489	5	)	)	-RRB-
cord-006860-a3b8hyyr	1489	6	were	be	VBD
cord-006860-a3b8hyyr	1489	7	associated	associate	VBN
cord-006860-a3b8hyyr	1489	8	with	with	IN
cord-006860-a3b8hyyr	1489	9	increased	increase	VBN
cord-006860-a3b8hyyr	1489	10	mortality	mortality	NN
cord-006860-a3b8hyyr	1489	11	(	(	-LRB-
cord-006860-a3b8hyyr	1489	12	16	16	CD
cord-006860-a3b8hyyr	1489	13	%	%	NN
cord-006860-a3b8hyyr	1489	14	and	and	CC
cord-006860-a3b8hyyr	1489	15	20	20	CD
cord-006860-a3b8hyyr	1489	16	%	%	NN
cord-006860-a3b8hyyr	1489	17	,	,	,
cord-006860-a3b8hyyr	1489	18	resp	resp	NNP
cord-006860-a3b8hyyr	1489	19	.	.	NNP
cord-006860-a3b8hyyr	1489	20	,	,	,
cord-006860-a3b8hyyr	1489	21	compared	compare	VBN
cord-006860-a3b8hyyr	1489	22	to	to	IN
cord-006860-a3b8hyyr	1489	23	4.5	4.5	CD
cord-006860-a3b8hyyr	1489	24	%	%	NN
cord-006860-a3b8hyyr	1489	25	overall	overall	JJ
cord-006860-a3b8hyyr	1489	26	mortality	mortality	NN
cord-006860-a3b8hyyr	1489	27	)	)	-RRB-
cord-006860-a3b8hyyr	1489	28	.	.	.
cord-006860-a3b8hyyr	1490	1	Five	five	CD
cord-006860-a3b8hyyr	1490	2	of	of	IN
cord-006860-a3b8hyyr	1490	3	29	29	CD
cord-006860-a3b8hyyr	1490	4	surviving	survive	VBG
cord-006860-a3b8hyyr	1490	5	children	child	NNS
cord-006860-a3b8hyyr	1490	6	with	with	IN
cord-006860-a3b8hyyr	1490	7	skin	skin	NN
cord-006860-a3b8hyyr	1490	8	necroses	necrose	NNS
cord-006860-a3b8hyyr	1490	9	required	require	VBD
cord-006860-a3b8hyyr	1490	10	surgical	surgical	JJ
cord-006860-a3b8hyyr	1490	11	interventions	intervention	NNS
cord-006860-a3b8hyyr	1490	12	(	(	-LRB-
cord-006860-a3b8hyyr	1490	13	skin	skin	NN
cord-006860-a3b8hyyr	1490	14	transplantation	transplantation	NN
cord-006860-a3b8hyyr	1490	15	and/or	and/or	CC
cord-006860-a3b8hyyr	1490	16	amputations	amputation	NNS
cord-006860-a3b8hyyr	1490	17	)	)	-RRB-
cord-006860-a3b8hyyr	1490	18	.	.	.
cord-006860-a3b8hyyr	1491	1	Petechiae	Petechiae	NNP
cord-006860-a3b8hyyr	1491	2	were	be	VBD
cord-006860-a3b8hyyr	1491	3	frequent	frequent	JJ
cord-006860-a3b8hyyr	1491	4	(	(	-LRB-
cord-006860-a3b8hyyr	1491	5	n	n	NN
cord-006860-a3b8hyyr	1491	6	=	=	SYM
cord-006860-a3b8hyyr	1491	7	156	156	CD
cord-006860-a3b8hyyr	1491	8	)	)	-RRB-
cord-006860-a3b8hyyr	1491	9	and	and	CC
cord-006860-a3b8hyyr	1491	10	as	as	IN
cord-006860-a3b8hyyr	1491	11	isolated	isolate	VBN
cord-006860-a3b8hyyr	1491	12	finding	finding	NN
cord-006860-a3b8hyyr	1491	13	not	not	RB
cord-006860-a3b8hyyr	1491	14	related	relate	VBN
cord-006860-a3b8hyyr	1491	15	to	to	IN
cord-006860-a3b8hyyr	1491	16	severe	severe	JJ
cord-006860-a3b8hyyr	1491	17	disease	disease	NN
cord-006860-a3b8hyyr	1491	18	or	or	CC
cord-006860-a3b8hyyr	1491	19	fatal	fatal	JJ
cord-006860-a3b8hyyr	1491	20	outcome	outcome	NN
cord-006860-a3b8hyyr	1491	21	(	(	-LRB-
cord-006860-a3b8hyyr	1491	22	6	6	CD
cord-006860-a3b8hyyr	1491	23	%	%	NN
cord-006860-a3b8hyyr	1491	24	mortaliy	mortaliy	JJ
cord-006860-a3b8hyyr	1491	25	)	)	-RRB-
cord-006860-a3b8hyyr	1491	26	.	.	.
cord-006860-a3b8hyyr	1492	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	1492	2	counts	count	VBZ
cord-006860-a3b8hyyr	1492	3	at	at	IN
cord-006860-a3b8hyyr	1492	4	admission	admission	NN
cord-006860-a3b8hyyr	1492	5	were	be	VBD
cord-006860-a3b8hyyr	1492	6	lower	low	JJR
cord-006860-a3b8hyyr	1492	7	in	in	IN
cord-006860-a3b8hyyr	1492	8	non	non	NNS
cord-006860-a3b8hyyr	1492	9	-	-	NNS
cord-006860-a3b8hyyr	1492	10	survivors	survivor	NNS
cord-006860-a3b8hyyr	1492	11	(	(	-LRB-
cord-006860-a3b8hyyr	1492	12	10th-90th	10th-90th	JJ
cord-006860-a3b8hyyr	1492	13	percentile	percentile	JJ
cord-006860-a3b8hyyr	1492	14	:	:	:
cord-006860-a3b8hyyr	1492	15	30	30	CD
cord-006860-a3b8hyyr	1492	16	-450.000	-450.000	CD
cord-006860-a3b8hyyr	1492	17	/	/	SYM
cord-006860-a3b8hyyr	1492	18	gl	gl	NNP
cord-006860-a3b8hyyr	1492	19	,	,	,
cord-006860-a3b8hyyr	1492	20	median	median	NN
cord-006860-a3b8hyyr	1492	21	:	:	:
cord-006860-a3b8hyyr	1492	22	139.000	139.000	CD
cord-006860-a3b8hyyr	1492	23	/	/	SYM
cord-006860-a3b8hyyr	1492	24	I.tl	I.tl	NNS
cord-006860-a3b8hyyr	1492	25	)	)	-RRB-
cord-006860-a3b8hyyr	1492	26	than	than	IN
cord-006860-a3b8hyyr	1492	27	in	in	IN
cord-006860-a3b8hyyr	1492	28	survivors	survivor	NNS
cord-006860-a3b8hyyr	1492	29	(	(	-LRB-
cord-006860-a3b8hyyr	1492	30	10th-90th	10th-90th	JJ
cord-006860-a3b8hyyr	1492	31	percentile	percentile	NN
cord-006860-a3b8hyyr	1492	32	:	:	:
cord-006860-a3b8hyyr	1492	33	140	140	CD
cord-006860-a3b8hyyr	1492	34	-480.000	-480.000	CD
cord-006860-a3b8hyyr	1492	35	/	/	SYM
cord-006860-a3b8hyyr	1492	36	I.tl	I.tl	NNS
cord-006860-a3b8hyyr	1492	37	,	,	,
cord-006860-a3b8hyyr	1493	1	median	median	NN
cord-006860-a3b8hyyr	1493	2	:	:	:
cord-006860-a3b8hyyr	1493	3	242.000	242.000	CD
cord-006860-a3b8hyyr	1493	4	/	/	SYM
cord-006860-a3b8hyyr	1493	5	gl	gl	NNP
cord-006860-a3b8hyyr	1493	6	)	)	-RRB-
cord-006860-a3b8hyyr	1493	7	.	.	.
cord-006860-a3b8hyyr	1494	1	AT	at	IN
cord-006860-a3b8hyyr	1494	2	III	iii	CD
cord-006860-a3b8hyyr	1494	3	values	value	NNS
cord-006860-a3b8hyyr	1494	4	showed	show	VBD
cord-006860-a3b8hyyr	1494	5	no	no	DT
cord-006860-a3b8hyyr	1494	6	difference	difference	NN
cord-006860-a3b8hyyr	1494	7	between	between	IN
cord-006860-a3b8hyyr	1494	8	survivors	survivor	NNS
cord-006860-a3b8hyyr	1494	9	and	and	CC
cord-006860-a3b8hyyr	1494	10	non	non	NNS
cord-006860-a3b8hyyr	1494	11	-	-	NNS
cord-006860-a3b8hyyr	1494	12	survivors	survivor	NNS
cord-006860-a3b8hyyr	1494	13	.	.	.
cord-006860-a3b8hyyr	1495	1	Protein	protein	NN
cord-006860-a3b8hyyr	1495	2	C	C	NNP
cord-006860-a3b8hyyr	1495	3	was	be	VBD
cord-006860-a3b8hyyr	1495	4	available	available	JJ
cord-006860-a3b8hyyr	1495	5	in	in	IN
cord-006860-a3b8hyyr	1495	6	few	few	JJ
cord-006860-a3b8hyyr	1495	7	patients	patient	NNS
cord-006860-a3b8hyyr	1495	8	(	(	-LRB-
cord-006860-a3b8hyyr	1495	9	n	n	NN
cord-006860-a3b8hyyr	1495	10	=	=	SYM
cord-006860-a3b8hyyr	1495	11	14	14	CD
cord-006860-a3b8hyyr	1495	12	)	)	-RRB-
cord-006860-a3b8hyyr	1495	13	:	:	:
cord-006860-a3b8hyyr	1495	14	in	in	IN
cord-006860-a3b8hyyr	1495	15	this	this	DT
cord-006860-a3b8hyyr	1495	16	subgroup	subgroup	NN
cord-006860-a3b8hyyr	1495	17	,	,	,
cord-006860-a3b8hyyr	1495	18	protein	protein	NN
cord-006860-a3b8hyyr	1495	19	C	C	NNP
cord-006860-a3b8hyyr	1495	20	was	be	VBD
cord-006860-a3b8hyyr	1495	21	lowered	lower	VBN
cord-006860-a3b8hyyr	1495	22	in	in	IN
cord-006860-a3b8hyyr	1495	23	patients	patient	NNS
cord-006860-a3b8hyyr	1495	24	with	with	IN
cord-006860-a3b8hyyr	1495	25	limited	limited	JJ
cord-006860-a3b8hyyr	1495	26	disease	disease	NN
cord-006860-a3b8hyyr	1495	27	(	(	-LRB-
cord-006860-a3b8hyyr	1495	28	10th-90th	10th-90th	JJ
cord-006860-a3b8hyyr	1495	29	percentile	percentile	JJ
cord-006860-a3b8hyyr	1495	30	:	:	:
cord-006860-a3b8hyyr	1495	31	20	20	CD
cord-006860-a3b8hyyr	1495	32	-105	-105	NN
cord-006860-a3b8hyyr	1495	33	%	%	NN
cord-006860-a3b8hyyr	1495	34	,	,	,
cord-006860-a3b8hyyr	1495	35	median	median	NN
cord-006860-a3b8hyyr	1495	36	:	:	:
cord-006860-a3b8hyyr	1495	37	48	48	CD
cord-006860-a3b8hyyr	1495	38	%	%	NN
cord-006860-a3b8hyyr	1495	39	)	)	-RRB-
cord-006860-a3b8hyyr	1495	40	as	as	RB
cord-006860-a3b8hyyr	1495	41	well	well	RB
cord-006860-a3b8hyyr	1495	42	as	as	IN
cord-006860-a3b8hyyr	1495	43	severe	severe	JJ
cord-006860-a3b8hyyr	1495	44	disease	disease	NN
cord-006860-a3b8hyyr	1495	45	(	(	-LRB-
cord-006860-a3b8hyyr	1496	1	10th-90th	10th-90th	JJ
cord-006860-a3b8hyyr	1496	2	percentile	percentile	JJ
cord-006860-a3b8hyyr	1496	3	:	:	:
cord-006860-a3b8hyyr	1496	4	30	30	CD
cord-006860-a3b8hyyr	1496	5	-75	-75	CD
cord-006860-a3b8hyyr	1496	6	%	%	NN
cord-006860-a3b8hyyr	1496	7	,	,	,
cord-006860-a3b8hyyr	1496	8	median	median	NN
cord-006860-a3b8hyyr	1496	9	:	:	:
cord-006860-a3b8hyyr	1496	10	60	60	CD
cord-006860-a3b8hyyr	1496	11	%	%	NN
cord-006860-a3b8hyyr	1496	12	)	)	-RRB-
cord-006860-a3b8hyyr	1496	13	.	.	.
cord-006860-a3b8hyyr	1497	1	In	in	IN
cord-006860-a3b8hyyr	1497	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	1497	3	,	,	,
cord-006860-a3b8hyyr	1497	4	the	the	DT
cord-006860-a3b8hyyr	1497	5	findings	finding	NNS
cord-006860-a3b8hyyr	1497	6	"	"	``
cord-006860-a3b8hyyr	1497	7	ecehymoses	ecehymose	NNS
cord-006860-a3b8hyyr	1497	8	"	"	''
cord-006860-a3b8hyyr	1497	9	and	and	CC
cord-006860-a3b8hyyr	1497	10	"	"	``
cord-006860-a3b8hyyr	1497	11	skin	skin	NN
cord-006860-a3b8hyyr	1497	12	necroses	necrose	NNS
cord-006860-a3b8hyyr	1497	13	"	"	''
cord-006860-a3b8hyyr	1497	14	were	be	VBD
cord-006860-a3b8hyyr	1497	15	related	relate	VBN
cord-006860-a3b8hyyr	1497	16	to	to	IN
cord-006860-a3b8hyyr	1497	17	fatal	fatal	JJ
cord-006860-a3b8hyyr	1497	18	outcome	outcome	NN
cord-006860-a3b8hyyr	1497	19	and	and	CC
cord-006860-a3b8hyyr	1497	20	therefore	therefore	RB
cord-006860-a3b8hyyr	1497	21	included	include	VBD
cord-006860-a3b8hyyr	1497	22	in	in	IN
cord-006860-a3b8hyyr	1497	23	a	a	DT
cord-006860-a3b8hyyr	1497	24	prognostic	prognostic	JJ
cord-006860-a3b8hyyr	1497	25	score	score	NN
cord-006860-a3b8hyyr	1497	26	for	for	IN
cord-006860-a3b8hyyr	1497	27	severity	severity	NN
cord-006860-a3b8hyyr	1497	28	of	of	IN
cord-006860-a3b8hyyr	1497	29	meningncoccal	meningncoccal	JJ
cord-006860-a3b8hyyr	1497	30	disease	disease	NN
cord-006860-a3b8hyyr	1497	31	.	.	.
cord-006860-a3b8hyyr	1498	1	The	the	DT
cord-006860-a3b8hyyr	1498	2	influence	influence	NN
cord-006860-a3b8hyyr	1498	3	of	of	IN
cord-006860-a3b8hyyr	1498	4	irradiation	irradiation	NN
cord-006860-a3b8hyyr	1498	5	on	on	IN
cord-006860-a3b8hyyr	1498	6	PAI	PAI	NNP
cord-006860-a3b8hyyr	1498	7	-	-	HYPH
cord-006860-a3b8hyyr	1498	8	I	I	NNP
cord-006860-a3b8hyyr	1498	9	and	and	CC
cord-006860-a3b8hyyr	1498	10	vWF	vwf	NN
cord-006860-a3b8hyyr	1498	11	levels	level	NNS
cord-006860-a3b8hyyr	1498	12	in	in	IN
cord-006860-a3b8hyyr	1498	13	human	human	JJ
cord-006860-a3b8hyyr	1498	14	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	1498	15	vein	vein	NN
cord-006860-a3b8hyyr	1498	16	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1498	17	cell	cell	NN
cord-006860-a3b8hyyr	1498	18	cultures	culture	NNS
cord-006860-a3b8hyyr	1498	19	K.	K.	NNP
cord-006860-a3b8hyyr	1498	20	Fragiadaki	Fragiadaki	NNP
cord-006860-a3b8hyyr	1498	21	,	,	,
cord-006860-a3b8hyyr	1498	22	C.	C.	NNP
cord-006860-a3b8hyyr	1498	23	Salat	Salat	NNP
cord-006860-a3b8hyyr	1498	24	,	,	,
cord-006860-a3b8hyyr	1498	25	R.	R.	NNP
cord-006860-a3b8hyyr	1498	26	Pihusch	Pihusch	NNP
cord-006860-a3b8hyyr	1498	27	,	,	,
cord-006860-a3b8hyyr	1498	28	B.	B.	NNP
cord-006860-a3b8hyyr	1498	29	Reinhardt	Reinhardt	NNP
cord-006860-a3b8hyyr	1498	30	,	,	,
cord-006860-a3b8hyyr	1498	31	M	M	NNP
cord-006860-a3b8hyyr	1498	32	Penovici	Penovici	NNP
cord-006860-a3b8hyyr	1498	33	,	,	,
cord-006860-a3b8hyyr	1499	1	E.	E.	NNP
cord-006860-a3b8hyyr	1499	2	Hiller	Hiller	NNP
cord-006860-a3b8hyyr	1499	3	Med	Med	NNP
cord-006860-a3b8hyyr	1499	4	.	.	.
cord-006860-a3b8hyyr	1499	5	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	1499	6	III	III	NNP
cord-006860-a3b8hyyr	1499	7	,	,	,
cord-006860-a3b8hyyr	1499	8	Klinikum	Klinikum	NNP
cord-006860-a3b8hyyr	1499	9	Grosshadern	Grosshadern	NNP
cord-006860-a3b8hyyr	1499	10	der	der	NNP
cord-006860-a3b8hyyr	1499	11	Ludwig	Ludwig	NNP
cord-006860-a3b8hyyr	1499	12	-	-	HYPH
cord-006860-a3b8hyyr	1499	13	Maximilians	Maximilians	NNP
cord-006860-a3b8hyyr	1499	14	-	-	HYPH
cord-006860-a3b8hyyr	1499	15	Universitat	Universitat	NNP
cord-006860-a3b8hyyr	1500	1	MOnchen	MOnchen	NNP
cord-006860-a3b8hyyr	1501	1	An	an	DT
cord-006860-a3b8hyyr	1501	2	elevation	elevation	NN
cord-006860-a3b8hyyr	1501	3	of	of	IN
cord-006860-a3b8hyyr	1501	4	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	1501	5	in	in	IN
cord-006860-a3b8hyyr	1501	6	bone	bone	NN
cord-006860-a3b8hyyr	1501	7	marrow	marrow	NN
cord-006860-a3b8hyyr	1501	8	transplant	transplant	NN
cord-006860-a3b8hyyr	1501	9	recipients	recipient	NNS
cord-006860-a3b8hyyr	1501	10	developing	develop	VBG
cord-006860-a3b8hyyr	1501	11	veno	veno	NNP
cord-006860-a3b8hyyr	1501	12	-	-	HYPH
cord-006860-a3b8hyyr	1501	13	occlusive	occlusive	JJ
cord-006860-a3b8hyyr	1501	14	disease	disease	NN
cord-006860-a3b8hyyr	1501	15	(	(	-LRB-
cord-006860-a3b8hyyr	1501	16	VOD	VOD	NNP
cord-006860-a3b8hyyr	1501	17	)	)	-RRB-
cord-006860-a3b8hyyr	1501	18	of	of	IN
cord-006860-a3b8hyyr	1501	19	the	the	DT
cord-006860-a3b8hyyr	1501	20	liver	liver	NN
cord-006860-a3b8hyyr	1501	21	has	have	VBZ
cord-006860-a3b8hyyr	1501	22	been	be	VBN
cord-006860-a3b8hyyr	1501	23	described	describe	VBN
cord-006860-a3b8hyyr	1501	24	earlier	early	RBR
cord-006860-a3b8hyyr	1501	25	.	.	.
cord-006860-a3b8hyyr	1502	1	Endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1502	2	cell	cell	NN
cord-006860-a3b8hyyr	1502	3	damage	damage	NN
cord-006860-a3b8hyyr	1502	4	due	due	IN
cord-006860-a3b8hyyr	1502	5	to	to	IN
cord-006860-a3b8hyyr	1502	6	the	the	DT
cord-006860-a3b8hyyr	1502	7	preparative	preparative	JJ
cord-006860-a3b8hyyr	1502	8	myeloablative	myeloablative	NNP
cord-006860-a3b8hyyr	1502	9	radioehemotherapy	radioehemotherapy	NNP
cord-006860-a3b8hyyr	1502	10	is	be	VBZ
cord-006860-a3b8hyyr	1502	11	supposed	suppose	VBN
cord-006860-a3b8hyyr	1502	12	to	to	TO
cord-006860-a3b8hyyr	1502	13	be	be	VB
cord-006860-a3b8hyyr	1502	14	an	an	DT
cord-006860-a3b8hyyr	1502	15	important	important	JJ
cord-006860-a3b8hyyr	1502	16	step	step	NN
cord-006860-a3b8hyyr	1502	17	in	in	IN
cord-006860-a3b8hyyr	1502	18	the	the	DT
cord-006860-a3b8hyyr	1502	19	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	1502	20	of	of	IN
cord-006860-a3b8hyyr	1502	21	the	the	DT
cord-006860-a3b8hyyr	1502	22	disease	disease	NN
cord-006860-a3b8hyyr	1502	23	,	,	,
cord-006860-a3b8hyyr	1502	24	which	which	WDT
cord-006860-a3b8hyyr	1502	25	is	be	VBZ
cord-006860-a3b8hyyr	1502	26	characterized	characterize	VBN
cord-006860-a3b8hyyr	1502	27	by	by	IN
cord-006860-a3b8hyyr	1502	28	an	an	DT
cord-006860-a3b8hyyr	1502	29	obstruction	obstruction	NN
cord-006860-a3b8hyyr	1502	30	of	of	IN
cord-006860-a3b8hyyr	1502	31	small	small	JJ
cord-006860-a3b8hyyr	1502	32	intrahepatic	intrahepatic	JJ
cord-006860-a3b8hyyr	1502	33	venules	venule	NNS
cord-006860-a3b8hyyr	1502	34	.	.	.
cord-006860-a3b8hyyr	1503	1	In	in	IN
cord-006860-a3b8hyyr	1503	2	order	order	NN
cord-006860-a3b8hyyr	1503	3	to	to	TO
cord-006860-a3b8hyyr	1503	4	investigate	investigate	VB
cord-006860-a3b8hyyr	1503	5	a	a	DT
cord-006860-a3b8hyyr	1503	6	possible	possible	JJ
cord-006860-a3b8hyyr	1503	7	role	role	NN
cord-006860-a3b8hyyr	1503	8	of	of	IN
cord-006860-a3b8hyyr	1503	9	irradiation	irradiation	NN
cord-006860-a3b8hyyr	1503	10	we	-PRON-	PRP
cord-006860-a3b8hyyr	1503	11	studied	study	VBD
cord-006860-a3b8hyyr	1503	12	the	the	DT
cord-006860-a3b8hyyr	1503	13	influence	influence	NN
cord-006860-a3b8hyyr	1503	14	of	of	IN
cord-006860-a3b8hyyr	1503	15	several	several	JJ
cord-006860-a3b8hyyr	1503	16	doses	dose	NNS
cord-006860-a3b8hyyr	1503	17	(	(	-LRB-
cord-006860-a3b8hyyr	1503	18	0	0	CD
cord-006860-a3b8hyyr	1503	19	,	,	,
cord-006860-a3b8hyyr	1503	20	5	5	CD
cord-006860-a3b8hyyr	1503	21	,	,	,
cord-006860-a3b8hyyr	1503	22	15	15	CD
cord-006860-a3b8hyyr	1503	23	,	,	,
cord-006860-a3b8hyyr	1503	24	30	30	CD
cord-006860-a3b8hyyr	1503	25	gy	gy	NN
cord-006860-a3b8hyyr	1503	26	)	)	-RRB-
cord-006860-a3b8hyyr	1503	27	on	on	IN
cord-006860-a3b8hyyr	1503	28	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	1503	29	and	and	CC
cord-006860-a3b8hyyr	1503	30	vWF	vwf	IN
cord-006860-a3b8hyyr	1503	31	levels	level	NNS
cord-006860-a3b8hyyr	1503	32	in	in	IN
cord-006860-a3b8hyyr	1503	33	the	the	DT
cord-006860-a3b8hyyr	1503	34	supematant	supematant	NN
cord-006860-a3b8hyyr	1503	35	of	of	IN
cord-006860-a3b8hyyr	1503	36	human	human	JJ
cord-006860-a3b8hyyr	1503	37	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	1503	38	vein	vein	NN
cord-006860-a3b8hyyr	1503	39	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1503	40	cell	cell	NN
cord-006860-a3b8hyyr	1503	41	cultures	culture	NNS
cord-006860-a3b8hyyr	1503	42	(	(	-LRB-
cord-006860-a3b8hyyr	1503	43	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	1503	44	)	)	-RRB-
cord-006860-a3b8hyyr	1503	45	.	.	.
cord-006860-a3b8hyyr	1504	1	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	1504	2	antigen	antigen	NN
cord-006860-a3b8hyyr	1504	3	and	and	CC
cord-006860-a3b8hyyr	1504	4	vWF	vwf	NN
cord-006860-a3b8hyyr	1504	5	were	be	VBD
cord-006860-a3b8hyyr	1504	6	determined	determine	VBN
cord-006860-a3b8hyyr	1504	7	by	by	IN
cord-006860-a3b8hyyr	1504	8	enzyme	enzyme	NN
cord-006860-a3b8hyyr	1504	9	immunoassays	immunoassay	NNS
cord-006860-a3b8hyyr	1504	10	.	.	.
cord-006860-a3b8hyyr	1505	1	Whereas	whereas	IN
cord-006860-a3b8hyyr	1505	2	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	1505	3	and	and	CC
cord-006860-a3b8hyyr	1505	4	vWF	vwf	IN
cord-006860-a3b8hyyr	1505	5	levels	level	NNS
cord-006860-a3b8hyyr	1505	6	remained	remain	VBD
cord-006860-a3b8hyyr	1505	7	unchanged	unchanged	JJ
cord-006860-a3b8hyyr	1505	8	alter	alter	NN
cord-006860-a3b8hyyr	1505	9	irradiation	irradiation	NN
cord-006860-a3b8hyyr	1505	10	with	with	IN
cord-006860-a3b8hyyr	1505	11	5	5	CD
cord-006860-a3b8hyyr	1505	12	Gy	Gy	NNP
cord-006860-a3b8hyyr	1505	13	and	and	CC
cord-006860-a3b8hyyr	1505	14	in	in	IN
cord-006860-a3b8hyyr	1505	15	control	control	NN
cord-006860-a3b8hyyr	1505	16	cultures	culture	NNS
cord-006860-a3b8hyyr	1505	17	,	,	,
cord-006860-a3b8hyyr	1505	18	a	a	DT
cord-006860-a3b8hyyr	1505	19	rise	rise	NN
cord-006860-a3b8hyyr	1505	20	was	be	VBD
cord-006860-a3b8hyyr	1505	21	observed	observe	VBN
cord-006860-a3b8hyyr	1505	22	one	one	CD
cord-006860-a3b8hyyr	1505	23	day	day	NN
cord-006860-a3b8hyyr	1505	24	after	after	IN
cord-006860-a3b8hyyr	1505	25	irradiation	irradiation	NN
cord-006860-a3b8hyyr	1505	26	with	with	IN
cord-006860-a3b8hyyr	1505	27	15	15	CD
cord-006860-a3b8hyyr	1505	28	Gy	Gy	NNP
cord-006860-a3b8hyyr	1505	29	(	(	-LRB-
cord-006860-a3b8hyyr	1505	30	mean	mean	JJ
cord-006860-a3b8hyyr	1505	31	day	day	NN
cord-006860-a3b8hyyr	1505	32	0"-)day	0"-)day	CD
cord-006860-a3b8hyyr	1505	33	+1	+1	XX
cord-006860-a3b8hyyr	1505	34	)	)	-RRB-
cord-006860-a3b8hyyr	1506	1	in	in	IN
cord-006860-a3b8hyyr	1506	2	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	1506	3	(	(	-LRB-
cord-006860-a3b8hyyr	1506	4	100,0	100,0	CD
cord-006860-a3b8hyyr	1506	5	%	%	NN
cord-006860-a3b8hyyr	1506	6	--)171,2	--)171,2	CD
cord-006860-a3b8hyyr	1506	7	%	%	NN
cord-006860-a3b8hyyr	1506	8	)	)	-RRB-
cord-006860-a3b8hyyr	1506	9	and	and	CC
cord-006860-a3b8hyyr	1506	10	vWF	vwf	NN
cord-006860-a3b8hyyr	1506	11	(	(	-LRB-
cord-006860-a3b8hyyr	1506	12	100%--)159,7	100%--)159,7	CD
cord-006860-a3b8hyyr	1506	13	%	%	NN
cord-006860-a3b8hyyr	1506	14	)	)	-RRB-
cord-006860-a3b8hyyr	1506	15	levels	level	NNS
cord-006860-a3b8hyyr	1506	16	.	.	.
cord-006860-a3b8hyyr	1507	1	The	the	DT
cord-006860-a3b8hyyr	1507	2	increase	increase	NN
cord-006860-a3b8hyyr	1507	3	was	be	VBD
cord-006860-a3b8hyyr	1507	4	more	more	RBR
cord-006860-a3b8hyyr	1507	5	pronounced	pronounced	JJ
cord-006860-a3b8hyyr	1507	6	and	and	CC
cord-006860-a3b8hyyr	1507	7	reached	reach	VBN
cord-006860-a3b8hyyr	1507	8	levels	level	NNS
cord-006860-a3b8hyyr	1507	9	of	of	IN
cord-006860-a3b8hyyr	1507	10	statistical	statistical	JJ
cord-006860-a3b8hyyr	1507	11	significance	significance	NN
cord-006860-a3b8hyyr	1507	12	after	after	IN
cord-006860-a3b8hyyr	1507	13	a	a	DT
cord-006860-a3b8hyyr	1507	14	dose	dose	NN
cord-006860-a3b8hyyr	1507	15	of	of	IN
cord-006860-a3b8hyyr	1507	16	30	30	CD
cord-006860-a3b8hyyr	1507	17	Cry	Cry	NNP
cord-006860-a3b8hyyr	1507	18	(	(	-LRB-
cord-006860-a3b8hyyr	1507	19	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	1507	20	100%--	100%--	CD
cord-006860-a3b8hyyr	1507	21	)	)	-RRB-
cord-006860-a3b8hyyr	1507	22	278,7	278,7	CD
cord-006860-a3b8hyyr	1507	23	%	%	NN
cord-006860-a3b8hyyr	1507	24	and	and	CC
cord-006860-a3b8hyyr	1507	25	vWF	vwf	NN
cord-006860-a3b8hyyr	1507	26	100%--)168	100%--)168	CD
cord-006860-a3b8hyyr	1507	27	%	%	NN
cord-006860-a3b8hyyr	1507	28	)	)	-RRB-
cord-006860-a3b8hyyr	1507	29	.	.	.
cord-006860-a3b8hyyr	1508	1	Both	both	DT
cord-006860-a3b8hyyr	1508	2	PAI-1	PAI-1	NNPS
cord-006860-a3b8hyyr	1508	3	and	and	CC
cord-006860-a3b8hyyr	1508	4	vWF	vwf	IN
cord-006860-a3b8hyyr	1508	5	levels	level	NNS
cord-006860-a3b8hyyr	1508	6	decreased	decrease	VBD
cord-006860-a3b8hyyr	1508	7	on	on	IN
cord-006860-a3b8hyyr	1508	8	day	day	NN
cord-006860-a3b8hyyr	1508	9	2	2	CD
cord-006860-a3b8hyyr	1508	10	after	after	IN
cord-006860-a3b8hyyr	1508	11	irradiation	irradiation	NN
cord-006860-a3b8hyyr	1508	12	with	with	IN
cord-006860-a3b8hyyr	1508	13	15	15	CD
cord-006860-a3b8hyyr	1508	14	and	and	CC
cord-006860-a3b8hyyr	1508	15	30	30	CD
cord-006860-a3b8hyyr	1508	16	gy	gy	NN
cord-006860-a3b8hyyr	1508	17	.	.	.
cord-006860-a3b8hyyr	1509	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	1509	2	results	result	NNS
cord-006860-a3b8hyyr	1509	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	1509	4	that	that	IN
cord-006860-a3b8hyyr	1509	5	irradiation	irradiation	NN
cord-006860-a3b8hyyr	1509	6	induces	induce	VBZ
cord-006860-a3b8hyyr	1509	7	an	an	DT
cord-006860-a3b8hyyr	1509	8	increase	increase	NN
cord-006860-a3b8hyyr	1509	9	of	of	IN
cord-006860-a3b8hyyr	1509	10	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	1509	11	and	and	CC
cord-006860-a3b8hyyr	1509	12	vWF	vwf	NN
cord-006860-a3b8hyyr	1509	13	in	in	IN
cord-006860-a3b8hyyr	1509	14	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1509	15	cells	cell	NNS
cord-006860-a3b8hyyr	1509	16	.	.	.
cord-006860-a3b8hyyr	1510	1	Nevertheless	nevertheless	RB
cord-006860-a3b8hyyr	1510	2	,	,	,
cord-006860-a3b8hyyr	1510	3	this	this	DT
cord-006860-a3b8hyyr	1510	4	effect	effect	NN
cord-006860-a3b8hyyr	1510	5	was	be	VBD
cord-006860-a3b8hyyr	1510	6	observed	observe	VBN
cord-006860-a3b8hyyr	1510	7	only	only	RB
cord-006860-a3b8hyyr	1510	8	in	in	IN
cord-006860-a3b8hyyr	1510	9	doses	dose	NNS
cord-006860-a3b8hyyr	1510	10	above	above	IN
cord-006860-a3b8hyyr	1510	11	those	those	DT
cord-006860-a3b8hyyr	1510	12	ones	one	NNS
cord-006860-a3b8hyyr	1510	13	used	use	VBN
cord-006860-a3b8hyyr	1510	14	during	during	IN
cord-006860-a3b8hyyr	1510	15	conditioning	conditioning	NN
cord-006860-a3b8hyyr	1510	16	when	when	WRB
cord-006860-a3b8hyyr	1510	17	patients	patient	NNS
cord-006860-a3b8hyyr	1510	18	receive	receive	VBP
cord-006860-a3b8hyyr	1510	19	3x4	3x4	CD
cord-006860-a3b8hyyr	1510	20	gy	gy	NN
cord-006860-a3b8hyyr	1510	21	.	.	.
cord-006860-a3b8hyyr	1511	1	Additional	additional	JJ
cord-006860-a3b8hyyr	1511	2	factors	factor	NNS
cord-006860-a3b8hyyr	1511	3	seem	seem	VBP
cord-006860-a3b8hyyr	1511	4	to	to	TO
cord-006860-a3b8hyyr	1511	5	be	be	VB
cord-006860-a3b8hyyr	1511	6	of	of	IN
cord-006860-a3b8hyyr	1511	7	significance	significance	NN
cord-006860-a3b8hyyr	1511	8	.	.	.
cord-006860-a3b8hyyr	1512	1	Cytokines	cytokine	NNS
cord-006860-a3b8hyyr	1512	2	like	like	IN
cord-006860-a3b8hyyr	1512	3	TNFo~	TNFo~	NNS
cord-006860-a3b8hyyr	1512	4	enhance	enhance	VBP
cord-006860-a3b8hyyr	1512	5	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	1512	6	and	and	CC
cord-006860-a3b8hyyr	1512	7	vWF	vwf	NN
cord-006860-a3b8hyyr	1512	8	in	in	IN
cord-006860-a3b8hyyr	1512	9	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1512	10	cell	cell	NN
cord-006860-a3b8hyyr	1512	11	cultures	culture	NNS
cord-006860-a3b8hyyr	1512	12	and	and	CC
cord-006860-a3b8hyyr	1512	13	are	be	VBP
cord-006860-a3b8hyyr	1512	14	known	know	VBN
cord-006860-a3b8hyyr	1512	15	to	to	TO
cord-006860-a3b8hyyr	1512	16	be	be	VB
cord-006860-a3b8hyyr	1512	17	elevated	elevate	VBN
cord-006860-a3b8hyyr	1512	18	in	in	IN
cord-006860-a3b8hyyr	1512	19	BMT	BMT	NNP
cord-006860-a3b8hyyr	1512	20	-	-	HYPH
cord-006860-a3b8hyyr	1512	21	associated	associate	VBN
cord-006860-a3b8hyyr	1512	22	complications	complication	NNS
cord-006860-a3b8hyyr	1512	23	.	.	.
cord-006860-a3b8hyyr	1513	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1513	2	can	can	MD
cord-006860-a3b8hyyr	1513	3	be	be	VB
cord-006860-a3b8hyyr	1513	4	speculated	speculate	VBN
cord-006860-a3b8hyyr	1513	5	that	that	IN
cord-006860-a3b8hyyr	1513	6	irradiation	irradiation	NN
cord-006860-a3b8hyyr	1513	7	in	in	IN
cord-006860-a3b8hyyr	1513	8	concert	concert	NN
cord-006860-a3b8hyyr	1513	9	with	with	IN
cord-006860-a3b8hyyr	1513	10	these	these	DT
cord-006860-a3b8hyyr	1513	11	factors	factor	NNS
cord-006860-a3b8hyyr	1513	12	may	may	MD
cord-006860-a3b8hyyr	1513	13	contribute	contribute	VB
cord-006860-a3b8hyyr	1513	14	to	to	IN
cord-006860-a3b8hyyr	1513	15	the	the	DT
cord-006860-a3b8hyyr	1513	16	development	development	NN
cord-006860-a3b8hyyr	1513	17	of	of	IN
cord-006860-a3b8hyyr	1513	18	veno	veno	NNP
cord-006860-a3b8hyyr	1513	19	-	-	HYPH
cord-006860-a3b8hyyr	1513	20	occlusive	occlusive	JJ
cord-006860-a3b8hyyr	1513	21	disease	disease	NN
cord-006860-a3b8hyyr	1513	22	.	.	.
cord-006860-a3b8hyyr	1514	1	Disseminated	disseminate	VBN
cord-006860-a3b8hyyr	1514	2	intravascular	intravascular	JJ
cord-006860-a3b8hyyr	1514	3	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1514	4	is	be	VBZ
cord-006860-a3b8hyyr	1514	5	characterized	characterize	VBN
cord-006860-a3b8hyyr	1514	6	by	by	IN
cord-006860-a3b8hyyr	1514	7	high	high	JJ
cord-006860-a3b8hyyr	1514	8	consumption	consumption	NN
cord-006860-a3b8hyyr	1514	9	of	of	IN
cord-006860-a3b8hyyr	1514	10	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1514	11	factors	factor	NNS
cord-006860-a3b8hyyr	1514	12	,	,	,
cord-006860-a3b8hyyr	1514	13	systemic	systemic	JJ
cord-006860-a3b8hyyr	1514	14	elevation	elevation	NN
cord-006860-a3b8hyyr	1514	15	of	of	IN
cord-006860-a3b8hyyr	1514	16	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1514	17	by	by	IN
cord-006860-a3b8hyyr	1514	18	tPA	tPA	NNP
cord-006860-a3b8hyyr	1514	19	and	and	CC
cord-006860-a3b8hyyr	1514	20	concomitant	concomitant	JJ
cord-006860-a3b8hyyr	1514	21	elevation	elevation	NN
cord-006860-a3b8hyyr	1514	22	of	of	IN
cord-006860-a3b8hyyr	1514	23	PAI	PAI	NNP
cord-006860-a3b8hyyr	1514	24	-	-	:
cord-006860-a3b8hyyr	1514	25	I	-PRON-	PRP
cord-006860-a3b8hyyr	1514	26	secreted	secrete	VBD
cord-006860-a3b8hyyr	1514	27	from	from	IN
cord-006860-a3b8hyyr	1514	28	inflamed	inflamed	JJ
cord-006860-a3b8hyyr	1514	29	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1514	30	cells	cell	NNS
cord-006860-a3b8hyyr	1514	31	.	.	.
cord-006860-a3b8hyyr	1515	1	In	in	IN
cord-006860-a3b8hyyr	1515	2	an	an	DT
cord-006860-a3b8hyyr	1515	3	attempt	attempt	NN
cord-006860-a3b8hyyr	1515	4	to	to	TO
cord-006860-a3b8hyyr	1515	5	investigate	investigate	VB
cord-006860-a3b8hyyr	1515	6	the	the	DT
cord-006860-a3b8hyyr	1515	7	contribution	contribution	NN
cord-006860-a3b8hyyr	1515	8	of	of	IN
cord-006860-a3b8hyyr	1515	9	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	1515	10	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	1515	11	,	,	,
cord-006860-a3b8hyyr	1515	12	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1515	13	cells	cell	NNS
cord-006860-a3b8hyyr	1515	14	lines	line	NNS
cord-006860-a3b8hyyr	1515	15	of	of	IN
cord-006860-a3b8hyyr	1515	16	microvascular	microvascular	JJ
cord-006860-a3b8hyyr	1515	17	origin	origin	NN
cord-006860-a3b8hyyr	1515	18	were	be	VBD
cord-006860-a3b8hyyr	1515	19	stimulated	stimulate	VBN
cord-006860-a3b8hyyr	1515	20	in	in	IN
cord-006860-a3b8hyyr	1515	21	vitro	vitro	FW
cord-006860-a3b8hyyr	1515	22	and	and	CC
cord-006860-a3b8hyyr	1515	23	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	1515	24	antigen	antigen	NN
cord-006860-a3b8hyyr	1515	25	was	be	VBD
cord-006860-a3b8hyyr	1515	26	measured	measure	VBN
cord-006860-a3b8hyyr	1515	27	2h	2h	CD
cord-006860-a3b8hyyr	1515	28	,	,	,
cord-006860-a3b8hyyr	1515	29	4h	4h	CD
cord-006860-a3b8hyyr	1515	30	and	and	CC
cord-006860-a3b8hyyr	1515	31	24h	24h	NNS
cord-006860-a3b8hyyr	1515	32	after	after	IN
cord-006860-a3b8hyyr	1515	33	stimulation	stimulation	NN
cord-006860-a3b8hyyr	1515	34	.	.	.
cord-006860-a3b8hyyr	1516	1	In	in	IN
cord-006860-a3b8hyyr	1516	2	contrast	contrast	NN
cord-006860-a3b8hyyr	1516	3	to	to	IN
cord-006860-a3b8hyyr	1516	4	results	result	NNS
cord-006860-a3b8hyyr	1516	5	published	publish	VBN
cord-006860-a3b8hyyr	1516	6	from	from	IN
cord-006860-a3b8hyyr	1516	7	experiments	experiment	NNS
cord-006860-a3b8hyyr	1516	8	performed	perform	VBN
cord-006860-a3b8hyyr	1516	9	with	with	IN
cord-006860-a3b8hyyr	1516	10	macrovascular	macrovascular	JJ
cord-006860-a3b8hyyr	1516	11	human	human	JJ
cord-006860-a3b8hyyr	1516	12	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	1516	13	vein	vein	NN
cord-006860-a3b8hyyr	1516	14	cells	cell	NNS
cord-006860-a3b8hyyr	1516	15	(	(	-LRB-
cord-006860-a3b8hyyr	1516	16	HUVE	HUVE	NNP
cord-006860-a3b8hyyr	1516	17	)	)	-RRB-
cord-006860-a3b8hyyr	1516	18	,	,	,
cord-006860-a3b8hyyr	1516	19	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1516	20	results	result	NNS
cord-006860-a3b8hyyr	1516	21	obtained	obtain	VBN
cord-006860-a3b8hyyr	1516	22	with	with	IN
cord-006860-a3b8hyyr	1516	23	3	3	CD
cord-006860-a3b8hyyr	1516	24	different	different	JJ
cord-006860-a3b8hyyr	1516	25	microvascular	microvascular	JJ
cord-006860-a3b8hyyr	1516	26	endothelia	endothelium	NNS
cord-006860-a3b8hyyr	1516	27	isolated	isolate	VBN
cord-006860-a3b8hyyr	1516	28	from	from	IN
cord-006860-a3b8hyyr	1516	29	skin	skin	NN
cord-006860-a3b8hyyr	1516	30	,	,	,
cord-006860-a3b8hyyr	1516	31	solid	solid	JJ
cord-006860-a3b8hyyr	1516	32	tumor	tumor	NN
cord-006860-a3b8hyyr	1516	33	tissue	tissue	NN
cord-006860-a3b8hyyr	1516	34	and	and	CC
cord-006860-a3b8hyyr	1516	35	bone	bone	NN
cord-006860-a3b8hyyr	1516	36	marrow	marrow	NN
cord-006860-a3b8hyyr	1516	37	revealed	reveal	VBD
cord-006860-a3b8hyyr	1516	38	that	that	IN
cord-006860-a3b8hyyr	1516	39	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	1516	40	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	1516	41	reduced	reduce	VBD
cord-006860-a3b8hyyr	1516	42	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	1516	43	antigen	antigen	NN
cord-006860-a3b8hyyr	1516	44	levels	level	NNS
cord-006860-a3b8hyyr	1516	45	.	.	.
cord-006860-a3b8hyyr	1517	1	In	in	IN
cord-006860-a3b8hyyr	1517	2	addition	addition	NN
cord-006860-a3b8hyyr	1517	3	to	to	IN
cord-006860-a3b8hyyr	1517	4	TNF	TNF	NNP
cord-006860-a3b8hyyr	1517	5	-	-	:
cord-006860-a3b8hyyr	1517	6	a	a	DT
cord-006860-a3b8hyyr	1517	7	(	(	-LRB-
cord-006860-a3b8hyyr	1517	8	25ng	25ng	NN
cord-006860-a3b8hyyr	1517	9	/	/	SYM
cord-006860-a3b8hyyr	1517	10	ml	ml	NN
cord-006860-a3b8hyyr	1517	11	)	)	-RRB-
cord-006860-a3b8hyyr	1517	12	and	and	CC
cord-006860-a3b8hyyr	1517	13	LPS	LPS	NNP
cord-006860-a3b8hyyr	1517	14	(	(	-LRB-
cord-006860-a3b8hyyr	1517	15	10pg	10pg	NNP
cord-006860-a3b8hyyr	1517	16	/	/	SYM
cord-006860-a3b8hyyr	1517	17	ml	ml	NN
cord-006860-a3b8hyyr	1517	18	)	)	-RRB-
cord-006860-a3b8hyyr	1517	19	,	,	,
cord-006860-a3b8hyyr	1517	20	we	-PRON-	PRP
cord-006860-a3b8hyyr	1517	21	found	find	VBD
cord-006860-a3b8hyyr	1517	22	that	that	IN
cord-006860-a3b8hyyr	1517	23	IL-10	IL-10	NNP
cord-006860-a3b8hyyr	1517	24	(	(	-LRB-
cord-006860-a3b8hyyr	1517	25	100	100	CD
cord-006860-a3b8hyyr	1517	26	U	u	NN
cord-006860-a3b8hyyr	1517	27	/	/	SYM
cord-006860-a3b8hyyr	1517	28	ml	ml	NN
cord-006860-a3b8hyyr	1517	29	)	)	-RRB-
cord-006860-a3b8hyyr	1517	30	and	and	CC
cord-006860-a3b8hyyr	1517	31	GM	GM	NNP
cord-006860-a3b8hyyr	1517	32	-	-	HYPH
cord-006860-a3b8hyyr	1517	33	CSF	CSF	NNP
cord-006860-a3b8hyyr	1517	34	(	(	-LRB-
cord-006860-a3b8hyyr	1517	35	100	100	CD
cord-006860-a3b8hyyr	1517	36	U	u	NN
cord-006860-a3b8hyyr	1517	37	/	/	SYM
cord-006860-a3b8hyyr	1517	38	rot	rot	VB
cord-006860-a3b8hyyr	1517	39	)	)	-RRB-
cord-006860-a3b8hyyr	1517	40	also	also	RB
cord-006860-a3b8hyyr	1517	41	reduced	reduce	VBN
cord-006860-a3b8hyyr	1517	42	PAI	PAI	NNP
cord-006860-a3b8hyyr	1517	43	-	-	HYPH
cord-006860-a3b8hyyr	1517	44	I	-PRON-	PRP
cord-006860-a3b8hyyr	1517	45	levels	level	NNS
cord-006860-a3b8hyyr	1517	46	within	within	IN
cord-006860-a3b8hyyr	1517	47	the	the	DT
cord-006860-a3b8hyyr	1517	48	first	first	JJ
cord-006860-a3b8hyyr	1517	49	2h	2h	CD
cord-006860-a3b8hyyr	1517	50	of	of	IN
cord-006860-a3b8hyyr	1517	51	incubation	incubation	NN
cord-006860-a3b8hyyr	1517	52	(	(	-LRB-
cord-006860-a3b8hyyr	1517	53	from	from	IN
cord-006860-a3b8hyyr	1517	54	120ng	120ng	NNP
cord-006860-a3b8hyyr	1517	55	/	/	SYM
cord-006860-a3b8hyyr	1517	56	ml	ml	NN
cord-006860-a3b8hyyr	1517	57	to	to	IN
cord-006860-a3b8hyyr	1517	58	80	80	CD
cord-006860-a3b8hyyr	1517	59	-	-	SYM
cord-006860-a3b8hyyr	1517	60	110	110	CD
cord-006860-a3b8hyyr	1517	61	ng	ng	NN
cord-006860-a3b8hyyr	1517	62	/	/	SYM
cord-006860-a3b8hyyr	1517	63	mll	mll	NNP
cord-006860-a3b8hyyr	1517	64	and	and	CC
cord-006860-a3b8hyyr	1517	65	the	the	DT
cord-006860-a3b8hyyr	1517	66	effect	effect	NN
cord-006860-a3b8hyyr	1517	67	was	be	VBD
cord-006860-a3b8hyyr	1517	68	even	even	RB
cord-006860-a3b8hyyr	1517	69	more	more	RBR
cord-006860-a3b8hyyr	1517	70	pronounced	pronounced	JJ
cord-006860-a3b8hyyr	1517	71	after	after	IN
cord-006860-a3b8hyyr	1517	72	4h	4h	CD
cord-006860-a3b8hyyr	1517	73	and	and	CC
cord-006860-a3b8hyyr	1517	74	24h	24h	NNPS
cord-006860-a3b8hyyr	1517	75	(	(	-LRB-
cord-006860-a3b8hyyr	1517	76	from	from	IN
cord-006860-a3b8hyyr	1517	77	380	380	CD
cord-006860-a3b8hyyr	1517	78	ng	ng	NN
cord-006860-a3b8hyyr	1517	79	/	/	SYM
cord-006860-a3b8hyyr	1517	80	ml	ml	NN
cord-006860-a3b8hyyr	1517	81	to	to	IN
cord-006860-a3b8hyyr	1517	82	250	250	CD
cord-006860-a3b8hyyr	1517	83	ng	ng	NN
cord-006860-a3b8hyyr	1517	84	/	/	SYM
cord-006860-a3b8hyyr	1517	85	ml	ml	NN
cord-006860-a3b8hyyr	1517	86	)	)	-RRB-
cord-006860-a3b8hyyr	1517	87	.	.	.
cord-006860-a3b8hyyr	1518	1	IL-1	IL-1	NNP
cord-006860-a3b8hyyr	1519	1	(	(	-LRB-
cord-006860-a3b8hyyr	1519	2	10	10	CD
cord-006860-a3b8hyyr	1519	3	U	U	NNP
cord-006860-a3b8hyyr	1519	4	/	/	SYM
cord-006860-a3b8hyyr	1519	5	ml	ml	NN
cord-006860-a3b8hyyr	1519	6	)	)	-RRB-
cord-006860-a3b8hyyr	1519	7	and	and	CC
cord-006860-a3b8hyyr	1519	8	LPS	LPS	NNP
cord-006860-a3b8hyyr	1519	9	(	(	-LRB-
cord-006860-a3b8hyyr	1519	10	10	10	CD
cord-006860-a3b8hyyr	1519	11	pg	pg	NNP
cord-006860-a3b8hyyr	1519	12	/	/	SYM
cord-006860-a3b8hyyr	1519	13	l	l	NN
cord-006860-a3b8hyyr	1519	14	)	)	-RRB-
cord-006860-a3b8hyyr	1519	15	also	also	RB
cord-006860-a3b8hyyr	1519	16	reduced	reduce	VBD
cord-006860-a3b8hyyr	1519	17	constitutive	constitutive	JJ
cord-006860-a3b8hyyr	1519	18	levels	level	NNS
cord-006860-a3b8hyyr	1519	19	of	of	IN
cord-006860-a3b8hyyr	1519	20	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	1520	1	but	but	CC
cord-006860-a3b8hyyr	1520	2	the	the	DT
cord-006860-a3b8hyyr	1520	3	effect	effect	NN
cord-006860-a3b8hyyr	1520	4	occured	occur	VBD
cord-006860-a3b8hyyr	1520	5	later	later	RB
cord-006860-a3b8hyyr	1520	6	than	than	IN
cord-006860-a3b8hyyr	1520	7	4h	4h	CD
cord-006860-a3b8hyyr	1520	8	after	after	IN
cord-006860-a3b8hyyr	1520	9	addition	addition	NN
cord-006860-a3b8hyyr	1520	10	of	of	IN
cord-006860-a3b8hyyr	1520	11	the	the	DT
cord-006860-a3b8hyyr	1520	12	stimulator	stimulator	NN
cord-006860-a3b8hyyr	1520	13	.	.	.
cord-006860-a3b8hyyr	1521	1	The	the	DT
cord-006860-a3b8hyyr	1521	2	strongest	strong	JJS
cord-006860-a3b8hyyr	1521	3	synergistic	synergistic	JJ
cord-006860-a3b8hyyr	1521	4	effect	effect	NN
cord-006860-a3b8hyyr	1521	5	was	be	VBD
cord-006860-a3b8hyyr	1521	6	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	1521	7	with	with	IN
cord-006860-a3b8hyyr	1521	8	GM	GM	NNP
cord-006860-a3b8hyyr	1521	9	-	-	HYPH
cord-006860-a3b8hyyr	1521	10	CSF	CSF	NNP
cord-006860-a3b8hyyr	1521	11	plus	plus	CC
cord-006860-a3b8hyyr	1522	1	IL-1	IL-1	NNP
cord-006860-a3b8hyyr	1522	2	resulting	result	VBG
cord-006860-a3b8hyyr	1522	3	in	in	IN
cord-006860-a3b8hyyr	1522	4	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	1522	5	suppression	suppression	NN
cord-006860-a3b8hyyr	1522	6	of	of	IN
cord-006860-a3b8hyyr	1522	7	50	50	CD
cord-006860-a3b8hyyr	1522	8	%	%	NN
cord-006860-a3b8hyyr	1522	9	after	after	IN
cord-006860-a3b8hyyr	1522	10	2h	2h	CD
cord-006860-a3b8hyyr	1522	11	and	and	CC
cord-006860-a3b8hyyr	1522	12	30	30	CD
cord-006860-a3b8hyyr	1522	13	%	%	NN
cord-006860-a3b8hyyr	1522	14	after	after	IN
cord-006860-a3b8hyyr	1522	15	24h	24h	NNS
cord-006860-a3b8hyyr	1522	16	.	.	.
cord-006860-a3b8hyyr	1523	1	In	in	IN
cord-006860-a3b8hyyr	1523	2	contrast	contrast	NN
cord-006860-a3b8hyyr	1523	3	,	,	,
cord-006860-a3b8hyyr	1523	4	G	G	NNP
cord-006860-a3b8hyyr	1523	5	-	-	HYPH
cord-006860-a3b8hyyr	1523	6	CSF	CSF	NNP
cord-006860-a3b8hyyr	1523	7	(	(	-LRB-
cord-006860-a3b8hyyr	1523	8	300	300	CD
cord-006860-a3b8hyyr	1523	9	U	U	NNP
cord-006860-a3b8hyyr	1523	10	/	/	SYM
cord-006860-a3b8hyyr	1523	11	ml	ml	NN
cord-006860-a3b8hyyr	1523	12	)	)	-RRB-
cord-006860-a3b8hyyr	1523	13	induced	induce	VBD
cord-006860-a3b8hyyr	1523	14	the	the	DT
cord-006860-a3b8hyyr	1523	15	immediate	immediate	JJ
cord-006860-a3b8hyyr	1523	16	(	(	-LRB-
cord-006860-a3b8hyyr	1523	17	120	120	CD
cord-006860-a3b8hyyr	1523	18	to	to	TO
cord-006860-a3b8hyyr	1523	19	140	140	CD
cord-006860-a3b8hyyr	1523	20	ng	ng	NN
cord-006860-a3b8hyyr	1523	21	/	/	SYM
cord-006860-a3b8hyyr	1523	22	ml	ml	NN
cord-006860-a3b8hyyr	1523	23	after	after	IN
cord-006860-a3b8hyyr	1523	24	2h	2h	CD
cord-006860-a3b8hyyr	1523	25	and	and	CC
cord-006860-a3b8hyyr	1523	26	380	380	CD
cord-006860-a3b8hyyr	1523	27	to	to	IN
cord-006860-a3b8hyyr	1523	28	420	420	CD
cord-006860-a3b8hyyr	1523	29	ng	ng	NN
cord-006860-a3b8hyyr	1523	30	/	/	SYM
cord-006860-a3b8hyyr	1523	31	ml	ml	NN
cord-006860-a3b8hyyr	1523	32	after	after	IN
cord-006860-a3b8hyyr	1523	33	24h	24h	NNS
cord-006860-a3b8hyyr	1523	34	)	)	-RRB-
cord-006860-a3b8hyyr	1524	1	upregulation	upregulation	NN
cord-006860-a3b8hyyr	1524	2	of	of	IN
cord-006860-a3b8hyyr	1524	3	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	1524	4	antigen	antigen	NN
cord-006860-a3b8hyyr	1524	5	.	.	.
cord-006860-a3b8hyyr	1525	1	Stimulation	stimulation	NN
cord-006860-a3b8hyyr	1525	2	of	of	IN
cord-006860-a3b8hyyr	1525	3	PAt-1	PAt-1	NNP
cord-006860-a3b8hyyr	1525	4	levels	level	NNS
cord-006860-a3b8hyyr	1525	5	was	be	VBD
cord-006860-a3b8hyyr	1525	6	also	also	RB
cord-006860-a3b8hyyr	1525	7	observed	observe	VBN
cord-006860-a3b8hyyr	1525	8	with	with	IN
cord-006860-a3b8hyyr	1525	9	TGF	TGF	NNP
cord-006860-a3b8hyyr	1525	10	-	-	HYPH
cord-006860-a3b8hyyr	1525	11	I~	I~	NNP
cord-006860-a3b8hyyr	1525	12	(	(	-LRB-
cord-006860-a3b8hyyr	1525	13	10	10	CD
cord-006860-a3b8hyyr	1525	14	pg	pg	NN
cord-006860-a3b8hyyr	1525	15	/	/	SYM
cord-006860-a3b8hyyr	1525	16	ml	ml	NNP
cord-006860-a3b8hyyr	1525	17	)	)	-RRB-
cord-006860-a3b8hyyr	1525	18	,	,	,
cord-006860-a3b8hyyr	1525	19	however	however	RB
cord-006860-a3b8hyyr	1525	20	not	not	RB
cord-006860-a3b8hyyr	1525	21	earlier	early	JJR
cord-006860-a3b8hyyr	1525	22	than	than	IN
cord-006860-a3b8hyyr	1525	23	18h	18h	NNS
cord-006860-a3b8hyyr	1525	24	of	of	IN
cord-006860-a3b8hyyr	1525	25	incubation	incubation	NN
cord-006860-a3b8hyyr	1525	26	.	.	.
cord-006860-a3b8hyyr	1526	1	Interestingly	interestingly	RB
cord-006860-a3b8hyyr	1526	2	,	,	,
cord-006860-a3b8hyyr	1526	3	both	both	CC
cord-006860-a3b8hyyr	1526	4	stimulatory	stimulatory	JJ
cord-006860-a3b8hyyr	1526	5	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	1526	6	,	,	,
cord-006860-a3b8hyyr	1526	7	ie	ie	FW
cord-006860-a3b8hyyr	1526	8	.	.	.
cord-006860-a3b8hyyr	1527	1	G	G	NNP
cord-006860-a3b8hyyr	1527	2	-	-	HYPH
cord-006860-a3b8hyyr	1527	3	CSF	CSF	NNP
cord-006860-a3b8hyyr	1527	4	and	and	CC
cord-006860-a3b8hyyr	1527	5	TGF-13	TGF-13	NNP
cord-006860-a3b8hyyr	1527	6	,	,	,
cord-006860-a3b8hyyr	1527	7	alone	alone	RB
cord-006860-a3b8hyyr	1527	8	were	be	VBD
cord-006860-a3b8hyyr	1527	9	able	able	JJ
cord-006860-a3b8hyyr	1527	10	to	to	TO
cord-006860-a3b8hyyr	1527	11	counteract	counteract	VB
cord-006860-a3b8hyyr	1527	12	the	the	DT
cord-006860-a3b8hyyr	1527	13	decrease	decrease	NN
cord-006860-a3b8hyyr	1527	14	of	of	IN
cord-006860-a3b8hyyr	1527	15	PAt-1	PAt-1	NNP
cord-006860-a3b8hyyr	1527	16	antigen	antigen	NN
cord-006860-a3b8hyyr	1527	17	by	by	IN
cord-006860-a3b8hyyr	1527	18	TNF	TNF	NNP
cord-006860-a3b8hyyr	1527	19	-	-	,
cord-006860-a3b8hyyr	1527	20	a	a	NNP
cord-006860-a3b8hyyr	1527	21	but	but	CC
cord-006860-a3b8hyyr	1527	22	only	only	RB
cord-006860-a3b8hyyr	1527	23	a	a	DT
cord-006860-a3b8hyyr	1527	24	combination	combination	NN
cord-006860-a3b8hyyr	1527	25	of	of	IN
cord-006860-a3b8hyyr	1527	26	G	G	NNP
cord-006860-a3b8hyyr	1527	27	-	-	HYPH
cord-006860-a3b8hyyr	1527	28	CSF	CSF	NNP
cord-006860-a3b8hyyr	1527	29	plus	plus	CC
cord-006860-a3b8hyyr	1527	30	TGF	TGF	NNP
cord-006860-a3b8hyyr	1527	31	-	-	HYPH
cord-006860-a3b8hyyr	1527	32	g	g	NNP
cord-006860-a3b8hyyr	1527	33	neutralized	neutralize	VBD
cord-006860-a3b8hyyr	1527	34	the	the	DT
cord-006860-a3b8hyyr	1527	35	effect	effect	NN
cord-006860-a3b8hyyr	1527	36	by	by	IN
cord-006860-a3b8hyyr	1527	37	IL-1	IL-1	NNP
cord-006860-a3b8hyyr	1527	38	.	.	.
cord-006860-a3b8hyyr	1528	1	Results	result	NNS
cord-006860-a3b8hyyr	1528	2	indicate	indicate	VBP
cord-006860-a3b8hyyr	1528	3	that	that	IN
cord-006860-a3b8hyyr	1528	4	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	1528	5	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	1528	6	regulate	regulate	VBP
cord-006860-a3b8hyyr	1528	7	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	1528	8	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1528	9	in	in	IN
cord-006860-a3b8hyyr	1528	10	a	a	DT
cord-006860-a3b8hyyr	1528	11	synergistic	synergistic	JJ
cord-006860-a3b8hyyr	1528	12	and	and	CC
cord-006860-a3b8hyyr	1528	13	antagonistic	antagonistic	JJ
cord-006860-a3b8hyyr	1528	14	fashion	fashion	NN
cord-006860-a3b8hyyr	1528	15	.	.	.
cord-006860-a3b8hyyr	1529	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1529	2	established	establish	VBD
cord-006860-a3b8hyyr	1529	3	the	the	DT
cord-006860-a3b8hyyr	1529	4	culture	culture	NN
cord-006860-a3b8hyyr	1529	5	of	of	IN
cord-006860-a3b8hyyr	1529	6	human	human	JJ
cord-006860-a3b8hyyr	1529	7	brain	brain	NN
cord-006860-a3b8hyyr	1529	8	microvascular	microvascular	NN
cord-006860-a3b8hyyr	1529	9	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1529	10	cells	cell	NNS
cord-006860-a3b8hyyr	1529	11	(	(	-LRB-
cord-006860-a3b8hyyr	1529	12	HBMEC	HBMEC	NNP
cord-006860-a3b8hyyr	1529	13	)	)	-RRB-
cord-006860-a3b8hyyr	1529	14	in	in	IN
cord-006860-a3b8hyyr	1529	15	order	order	NN
cord-006860-a3b8hyyr	1529	16	to	to	TO
cord-006860-a3b8hyyr	1529	17	investigate	investigate	VB
cord-006860-a3b8hyyr	1529	18	the	the	DT
cord-006860-a3b8hyyr	1529	19	pathophysiology	pathophysiology	NN
cord-006860-a3b8hyyr	1529	20	of	of	IN
cord-006860-a3b8hyyr	1529	21	hu	hu	NNP
cord-006860-a3b8hyyr	1529	22	~	~	NFP
cord-006860-a3b8hyyr	1529	23	man	man	NN
cord-006860-a3b8hyyr	1529	24	cerebral	cerebral	NNP
cord-006860-a3b8hyyr	1529	25	malada	malada	NNP
cord-006860-a3b8hyyr	1529	26	,	,	,
cord-006860-a3b8hyyr	1529	27	which	which	WDT
cord-006860-a3b8hyyr	1529	28	is	be	VBZ
cord-006860-a3b8hyyr	1529	29	still	still	RB
cord-006860-a3b8hyyr	1529	30	associated	associate	VBN
cord-006860-a3b8hyyr	1529	31	with	with	IN
cord-006860-a3b8hyyr	1529	32	a	a	DT
cord-006860-a3b8hyyr	1529	33	high	high	JJ
cord-006860-a3b8hyyr	1529	34	mortality	mortality	NN
cord-006860-a3b8hyyr	1529	35	rate	rate	NN
cord-006860-a3b8hyyr	1529	36	.	.	.
cord-006860-a3b8hyyr	1530	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1530	2	is	be	VBZ
cord-006860-a3b8hyyr	1530	3	widely	widely	RB
cord-006860-a3b8hyyr	1530	4	accepted	accept	VBN
cord-006860-a3b8hyyr	1530	5	that	that	IN
cord-006860-a3b8hyyr	1530	6	among	among	IN
cord-006860-a3b8hyyr	1530	7	the	the	DT
cord-006860-a3b8hyyr	1530	8	reasons	reason	NNS
cord-006860-a3b8hyyr	1530	9	for	for	IN
cord-006860-a3b8hyyr	1530	10	the	the	DT
cord-006860-a3b8hyyr	1530	11	fatal	fatal	JJ
cord-006860-a3b8hyyr	1530	12	outcome	outcome	NN
cord-006860-a3b8hyyr	1530	13	of	of	IN
cord-006860-a3b8hyyr	1530	14	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	1530	15	malaria	malaria	NN
cord-006860-a3b8hyyr	1530	16	,	,	,
cord-006860-a3b8hyyr	1530	17	the	the	DT
cord-006860-a3b8hyyr	1530	18	interaction	interaction	NN
cord-006860-a3b8hyyr	1530	19	of	of	IN
cord-006860-a3b8hyyr	1530	20	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1530	21	cells	cell	NNS
cord-006860-a3b8hyyr	1530	22	with	with	IN
cord-006860-a3b8hyyr	1530	23	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	1530	24	and	and	CC
cord-006860-a3b8hyyr	1530	25	paras	paras	NNP
cord-006860-a3b8hyyr	1530	26	lites	lite	NNS
cord-006860-a3b8hyyr	1530	27	with	with	IN
cord-006860-a3b8hyyr	1530	28	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	1530	29	changes	change	NNS
cord-006860-a3b8hyyr	1530	30	in	in	IN
cord-006860-a3b8hyyr	1530	31	haemostaseological	haemostaseological	JJ
cord-006860-a3b8hyyr	1530	32	parameters	parameter	NNS
cord-006860-a3b8hyyr	1530	33	is	be	VBZ
cord-006860-a3b8hyyr	1530	34	involved	involve	VBN
cord-006860-a3b8hyyr	1530	35	.	.	.
cord-006860-a3b8hyyr	1531	1	The	the	DT
cord-006860-a3b8hyyr	1531	2	human	human	JJ
cord-006860-a3b8hyyr	1531	3	microvascular	microvascular	JJ
cord-006860-a3b8hyyr	1531	4	endothelium	endothelium	NN
cord-006860-a3b8hyyr	1531	5	may	may	MD
cord-006860-a3b8hyyr	1531	6	therefore	therefore	RB
cord-006860-a3b8hyyr	1531	7	play	play	VB
cord-006860-a3b8hyyr	1531	8	a	a	DT
cord-006860-a3b8hyyr	1531	9	deci	deci	NNS
cord-006860-a3b8hyyr	1531	10	§	§	.
cord-006860-a3b8hyyr	1532	1	i	-PRON-	PRP
cord-006860-a3b8hyyr	1532	2	ve	have	VB
cord-006860-a3b8hyyr	1532	3	role	role	NN
cord-006860-a3b8hyyr	1532	4	in	in	IN
cord-006860-a3b8hyyr	1532	5	the	the	DT
cord-006860-a3b8hyyr	1532	6	pathophysiology	pathophysiology	NN
cord-006860-a3b8hyyr	1532	7	of	of	IN
cord-006860-a3b8hyyr	1532	8	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	1532	9	malaria	malaria	NN
cord-006860-a3b8hyyr	1532	10	.	.	.
cord-006860-a3b8hyyr	1533	1	Ery	Ery	NNP
cord-006860-a3b8hyyr	1533	2	throcytes	throcyte	NNS
cord-006860-a3b8hyyr	1533	3	containing	contain	VBG
cord-006860-a3b8hyyr	1533	4	later	later	RB
cord-006860-a3b8hyyr	1533	5	stages	stage	NNS
cord-006860-a3b8hyyr	1533	6	of	of	IN
cord-006860-a3b8hyyr	1533	7	P.	P.	NNP
cord-006860-a3b8hyyr	1533	8	falciparum	falciparum	NN
cord-006860-a3b8hyyr	1533	9	specifically	specifically	RB
cord-006860-a3b8hyyr	1533	10	bind	bind	VBP
cord-006860-a3b8hyyr	1533	11	to	to	IN
cord-006860-a3b8hyyr	1533	12	capillary	capillary	JJ
cord-006860-a3b8hyyr	1533	13	EC	EC	NNP
cord-006860-a3b8hyyr	1533	14	in	in	IN
cord-006860-a3b8hyyr	1533	15	vivo	vivo	NN
cord-006860-a3b8hyyr	1533	16	(	(	-LRB-
cord-006860-a3b8hyyr	1533	17	sequestration	sequestration	NN
cord-006860-a3b8hyyr	1533	18	)	)	-RRB-
cord-006860-a3b8hyyr	1533	19	.	.	.
cord-006860-a3b8hyyr	1534	1	TNF	TNF	NNP
cord-006860-a3b8hyyr	1534	2	-	-	HYPH
cord-006860-a3b8hyyr	1534	3	cq	cq	NNP
cord-006860-a3b8hyyr	1535	1	IL-1	IL-1	NNP
cord-006860-a3b8hyyr	1535	2	and	and	CC
cord-006860-a3b8hyyr	1535	3	IL-6	IL-6	NNP
cord-006860-a3b8hyyr	1535	4	are	be	VBP
cord-006860-a3b8hyyr	1535	5	considerably	considerably	RB
cord-006860-a3b8hyyr	1535	6	elevated	elevate	VBN
cord-006860-a3b8hyyr	1535	7	in	in	IN
cord-006860-a3b8hyyr	1535	8	severe	severe	JJ
cord-006860-a3b8hyyr	1535	9	malaria	malaria	NN
cord-006860-a3b8hyyr	1535	10	.	.	.
cord-006860-a3b8hyyr	1536	1	Coagulation	coagulation	NN
cord-006860-a3b8hyyr	1536	2	factors	factor	NNS
cord-006860-a3b8hyyr	1536	3	such	such	JJ
cord-006860-a3b8hyyr	1536	4	as	as	IN
cord-006860-a3b8hyyr	1536	5	tissue	tissue	NN
cord-006860-a3b8hyyr	1536	6	factor	factor	NN
cord-006860-a3b8hyyr	1536	7	and	and	CC
cord-006860-a3b8hyyr	1536	8	von	von	NNP
cord-006860-a3b8hyyr	1536	9	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	1536	10	factor	factor	NN
cord-006860-a3b8hyyr	1536	11	are	be	VBP
cord-006860-a3b8hyyr	1536	12	affected	affect	VBN
cord-006860-a3b8hyyr	1536	13	by	by	IN
cord-006860-a3b8hyyr	1536	14	malada	malada	NNP
cord-006860-a3b8hyyr	1536	15	suggesting	suggest	VBG
cord-006860-a3b8hyyr	1536	16	the	the	DT
cord-006860-a3b8hyyr	1536	17	involvement	involvement	NN
cord-006860-a3b8hyyr	1536	18	of	of	IN
cord-006860-a3b8hyyr	1536	19	the	the	DT
cord-006860-a3b8hyyr	1536	20	HBMEC	HBMEC	NNP
cord-006860-a3b8hyyr	1536	21	in	in	IN
cord-006860-a3b8hyyr	1536	22	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	1536	23	malada	malada	NNP
cord-006860-a3b8hyyr	1536	24	.	.	.
cord-006860-a3b8hyyr	1537	1	So	so	RB
cord-006860-a3b8hyyr	1537	2	far	far	RB
cord-006860-a3b8hyyr	1537	3	,	,	,
cord-006860-a3b8hyyr	1537	4	research	research	NN
cord-006860-a3b8hyyr	1537	5	on	on	IN
cord-006860-a3b8hyyr	1537	6	the	the	DT
cord-006860-a3b8hyyr	1537	7	involvement	involvement	NN
cord-006860-a3b8hyyr	1537	8	of	of	IN
cord-006860-a3b8hyyr	1537	9	the	the	DT
cord-006860-a3b8hyyr	1537	10	HBMEC	HBMEC	NNP
cord-006860-a3b8hyyr	1537	11	has	have	VBZ
cord-006860-a3b8hyyr	1537	12	been	be	VBN
cord-006860-a3b8hyyr	1537	13	performed	perform	VBN
cord-006860-a3b8hyyr	1537	14	on	on	IN
cord-006860-a3b8hyyr	1537	15	EC	EC	NNP
cord-006860-a3b8hyyr	1537	16	cultured	culture	VBN
cord-006860-a3b8hyyr	1537	17	from	from	IN
cord-006860-a3b8hyyr	1537	18	human	human	JJ
cord-006860-a3b8hyyr	1537	19	umblilical	umblilical	JJ
cord-006860-a3b8hyyr	1537	20	veins	vein	NNS
cord-006860-a3b8hyyr	1537	21	(	(	-LRB-
cord-006860-a3b8hyyr	1537	22	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	1537	23	)	)	-RRB-
cord-006860-a3b8hyyr	1537	24	.	.	.
cord-006860-a3b8hyyr	1538	1	The	the	DT
cord-006860-a3b8hyyr	1538	2	relevance	relevance	NN
cord-006860-a3b8hyyr	1538	3	of	of	IN
cord-006860-a3b8hyyr	1538	4	this	this	DT
cord-006860-a3b8hyyr	1538	5	model	model	NN
cord-006860-a3b8hyyr	1538	6	may	may	MD
cord-006860-a3b8hyyr	1538	7	be	be	VB
cord-006860-a3b8hyyr	1538	8	questioned	question	VBN
cord-006860-a3b8hyyr	1538	9	on	on	IN
cord-006860-a3b8hyyr	1538	10	t	t	NNP
cord-006860-a3b8hyyr	1538	11	,	,	,
cord-006860-a3b8hyyr	1538	12	,	,	,
cord-006860-a3b8hyyr	1538	13	he	-PRON-	PRP
cord-006860-a3b8hyyr	1538	14	grounds	ground	VBZ
cord-006860-a3b8hyyr	1538	15	that	that	IN
cord-006860-a3b8hyyr	1538	16	the	the	DT
cord-006860-a3b8hyyr	1538	17	capillary	capillary	JJ
cord-006860-a3b8hyyr	1538	18	endothelium	endothelium	NN
cord-006860-a3b8hyyr	1538	19	probably	probably	RB
cord-006860-a3b8hyyr	1538	20	plays	play	VBZ
cord-006860-a3b8hyyr	1538	21	a	a	DT
cord-006860-a3b8hyyr	1538	22	greater	great	JJR
cord-006860-a3b8hyyr	1538	23	role	role	NN
cord-006860-a3b8hyyr	1538	24	than	than	IN
cord-006860-a3b8hyyr	1538	25	the	the	DT
cord-006860-a3b8hyyr	1538	26	endothelium	endothelium	NN
cord-006860-a3b8hyyr	1538	27	of	of	IN
cord-006860-a3b8hyyr	1538	28	the	the	DT
cord-006860-a3b8hyyr	1538	29	large	large	JJ
cord-006860-a3b8hyyr	1538	30	vessels	vessel	NNS
cord-006860-a3b8hyyr	1538	31	.	.	.
cord-006860-a3b8hyyr	1539	1	Besides	besides	RB
cord-006860-a3b8hyyr	1539	2	,	,	,
cord-006860-a3b8hyyr	1539	3	some	some	DT
cord-006860-a3b8hyyr	1539	4	propertie.$	propertie.$	NN
cord-006860-a3b8hyyr	1539	5	of	of	IN
cord-006860-a3b8hyyr	1539	6	the	the	DT
cord-006860-a3b8hyyr	1539	7	endothelioum	endothelioum	NNP
cord-006860-a3b8hyyr	1539	8	seem	seem	VBP
cord-006860-a3b8hyyr	1539	9	to	to	TO
cord-006860-a3b8hyyr	1539	10	vary	vary	VB
cord-006860-a3b8hyyr	1539	11	,	,	,
cord-006860-a3b8hyyr	1539	12	upon	upon	IN
cord-006860-a3b8hyyr	1539	13	the	the	DT
cord-006860-a3b8hyyr	1539	14	organ	organ	NN
cord-006860-a3b8hyyr	1539	15	of	of	IN
cord-006860-a3b8hyyr	1539	16	origi	origi	NNP
cord-006860-a3b8hyyr	1539	17	/	/	SYM
cord-006860-a3b8hyyr	1539	18	n	n	NNP
cord-006860-a3b8hyyr	1539	19	.	.	.
cord-006860-a3b8hyyr	1540	1	For	for	IN
cord-006860-a3b8hyyr	1540	2	the~	the~	CD
cord-006860-a3b8hyyr	1540	3	reasons	reason	NNS
cord-006860-a3b8hyyr	1540	4	,	,	,
cord-006860-a3b8hyyr	1540	5	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1540	6	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1540	7	has	have	VBZ
cord-006860-a3b8hyyr	1540	8	established	establish	VBN
cord-006860-a3b8hyyr	1540	9	the	the	DT
cord-006860-a3b8hyyr	1540	10	HBMEC	HBMEC	NNP
cord-006860-a3b8hyyr	1540	11	as	as	IN
cord-006860-a3b8hyyr	1540	12	a	a	DT
cord-006860-a3b8hyyr	1540	13	model	model	NN
cord-006860-a3b8hyyr	1540	14	to	to	TO
cord-006860-a3b8hyyr	1540	15	study	study	VB
cord-006860-a3b8hyyr	1540	16	the	the	DT
cord-006860-a3b8hyyr	1540	17	pathophysiology	pathophysiology	NN
cord-006860-a3b8hyyr	1540	18	of	of	IN
cord-006860-a3b8hyyr	1540	19	human	human	JJ
cord-006860-a3b8hyyr	1540	20	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	1540	21	malaria	malaria	NN
cord-006860-a3b8hyyr	1540	22	.	.	.
cord-006860-a3b8hyyr	1541	1	To	to	TO
cord-006860-a3b8hyyr	1541	2	demonstrate	demonstrate	VB
cord-006860-a3b8hyyr	1541	3	the	the	DT
cord-006860-a3b8hyyr	1541	4	relevance	relevance	NN
cord-006860-a3b8hyyr	1541	5	of	of	IN
cord-006860-a3b8hyyr	1541	6	this	this	DT
cord-006860-a3b8hyyr	1541	7	model	model	NN
cord-006860-a3b8hyyr	1541	8	in	in	IN
cord-006860-a3b8hyyr	1541	9	the	the	DT
cord-006860-a3b8hyyr	1541	10	context	context	NN
cord-006860-a3b8hyyr	1541	11	of	of	IN
cord-006860-a3b8hyyr	1541	12	malaria	malaria	NN
cord-006860-a3b8hyyr	1541	13	,	,	,
cord-006860-a3b8hyyr	1541	14	HBMEC	HBMEC	NNP
cord-006860-a3b8hyyr	1541	15	were	be	VBD
cord-006860-a3b8hyyr	1541	16	challenged	challenge	VBN
cord-006860-a3b8hyyr	1541	17	with	with	IN
cord-006860-a3b8hyyr	1541	18	sera	sera	NNP
cord-006860-a3b8hyyr	1541	19	from	from	IN
cord-006860-a3b8hyyr	1541	20	different	different	JJ
cord-006860-a3b8hyyr	1541	21	patients	patient	NNS
cord-006860-a3b8hyyr	1541	22	with	with	IN
cord-006860-a3b8hyyr	1541	23	severe	severe	JJ
cord-006860-a3b8hyyr	1541	24	P.	P.	NNP
cord-006860-a3b8hyyr	1541	25	falciparum	falciparum	NN
cord-006860-a3b8hyyr	1541	26	malaria	malaria	NN
cord-006860-a3b8hyyr	1541	27	and	and	CC
cord-006860-a3b8hyyr	1541	28	with	with	IN
cord-006860-a3b8hyyr	1541	29	serum	serum	NN
cord-006860-a3b8hyyr	1541	30	from	from	IN
cord-006860-a3b8hyyr	1541	31	a	a	DT
cord-006860-a3b8hyyr	1541	32	healthy	healthy	JJ
cord-006860-a3b8hyyr	1541	33	donor	donor	NN
cord-006860-a3b8hyyr	1541	34	.	.	.
cord-006860-a3b8hyyr	1542	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1542	2	can	can	MD
cord-006860-a3b8hyyr	1542	3	demonstrate	demonstrate	VB
cord-006860-a3b8hyyr	1542	4	that	that	IN
cord-006860-a3b8hyyr	1542	5	in	in	IN
cord-006860-a3b8hyyr	1542	6	cells	cell	NNS
cord-006860-a3b8hyyr	1542	7	challenged	challenge	VBN
cord-006860-a3b8hyyr	1542	8	with	with	IN
cord-006860-a3b8hyyr	1542	9	malaria	malaria	NN
cord-006860-a3b8hyyr	1542	10	patient	patient	NN
cord-006860-a3b8hyyr	1542	11	sera	sera	NNP
cord-006860-a3b8hyyr	1542	12	ICAM-1	ICAM-1	NNP
cord-006860-a3b8hyyr	1542	13	and	and	CC
cord-006860-a3b8hyyr	1542	14	Substance	Substance	NNP
cord-006860-a3b8hyyr	1542	15	P	P	NNP
cord-006860-a3b8hyyr	1542	16	were	be	VBD
cord-006860-a3b8hyyr	1542	17	upregulated	upregulate	VBN
cord-006860-a3b8hyyr	1542	18	.	.	.
cord-006860-a3b8hyyr	1543	1	On	on	IN
cord-006860-a3b8hyyr	1543	2	the	the	DT
cord-006860-a3b8hyyr	1543	3	other	other	JJ
cord-006860-a3b8hyyr	1543	4	hand	hand	NN
cord-006860-a3b8hyyr	1543	5	cells	cell	NNS
cord-006860-a3b8hyyr	1543	6	challenged	challenge	VBN
cord-006860-a3b8hyyr	1543	7	with	with	IN
cord-006860-a3b8hyyr	1543	8	serum	serum	NN
cord-006860-a3b8hyyr	1543	9	from	from	IN
cord-006860-a3b8hyyr	1543	10	a	a	DT
cord-006860-a3b8hyyr	1543	11	healthy	healthy	JJ
cord-006860-a3b8hyyr	1543	12	donor	donor	NN
cord-006860-a3b8hyyr	1543	13	expressed	express	VBD
cord-006860-a3b8hyyr	1543	14	neither	neither	CC
cord-006860-a3b8hyyr	1543	15	ICAM-1	ICAM-1	NNP
cord-006860-a3b8hyyr	1543	16	nor	nor	CC
cord-006860-a3b8hyyr	1543	17	Substance	Substance	NNP
cord-006860-a3b8hyyr	1543	18	P.	P.	NNP
cord-006860-a3b8hyyr	1544	1	These	these	DT
cord-006860-a3b8hyyr	1544	2	results	result	NNS
cord-006860-a3b8hyyr	1544	3	strongly	strongly	RB
cord-006860-a3b8hyyr	1544	4	suggest	suggest	VBP
cord-006860-a3b8hyyr	1544	5	the	the	DT
cord-006860-a3b8hyyr	1544	6	relevance	relevance	NN
cord-006860-a3b8hyyr	1544	7	of	of	IN
cord-006860-a3b8hyyr	1544	8	this	this	DT
cord-006860-a3b8hyyr	1544	9	model	model	NN
cord-006860-a3b8hyyr	1544	10	for	for	IN
cord-006860-a3b8hyyr	1544	11	vessel	vessel	NN
cord-006860-a3b8hyyr	1544	12	involvement	involvement	NN
cord-006860-a3b8hyyr	1544	13	in	in	IN
cord-006860-a3b8hyyr	1544	14	malaria	malaria	NN
cord-006860-a3b8hyyr	1544	15	.	.	.
cord-006860-a3b8hyyr	1545	1	Both	both	DT
cord-006860-a3b8hyyr	1545	2	,	,	,
cord-006860-a3b8hyyr	1545	3	histamine	histamine	NN
cord-006860-a3b8hyyr	1545	4	and	and	CC
cord-006860-a3b8hyyr	1545	5	serotonin	serotonin	NN
cord-006860-a3b8hyyr	1545	6	have	have	VBP
cord-006860-a3b8hyyr	1545	7	been	be	VBN
cord-006860-a3b8hyyr	1545	8	described	describe	VBN
cord-006860-a3b8hyyr	1545	9	as	as	IN
cord-006860-a3b8hyyr	1545	10	potent	potent	JJ
cord-006860-a3b8hyyr	1545	11	stimulators	stimulator	NNS
cord-006860-a3b8hyyr	1545	12	of	of	IN
cord-006860-a3b8hyyr	1545	13	yon	yon	NNP
cord-006860-a3b8hyyr	1545	14	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	1545	15	factor	factor	NN
cord-006860-a3b8hyyr	1545	16	(	(	-LRB-
cord-006860-a3b8hyyr	1545	17	vWf	vWf	NNS
cord-006860-a3b8hyyr	1545	18	)	)	-RRB-
cord-006860-a3b8hyyr	1545	19	release	release	NN
cord-006860-a3b8hyyr	1545	20	from	from	IN
cord-006860-a3b8hyyr	1545	21	human	human	JJ
cord-006860-a3b8hyyr	1545	22	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	1545	23	vein	vein	NN
cord-006860-a3b8hyyr	1545	24	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1545	25	cells	cell	NNS
cord-006860-a3b8hyyr	1545	26	(	(	-LRB-
cord-006860-a3b8hyyr	1545	27	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	1545	28	)	)	-RRB-
cord-006860-a3b8hyyr	1545	29	.	.	.
cord-006860-a3b8hyyr	1546	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1546	2	performed	perform	VBD
cord-006860-a3b8hyyr	1546	3	experiments	experiment	NNS
cord-006860-a3b8hyyr	1546	4	to	to	TO
cord-006860-a3b8hyyr	1546	5	differentiate	differentiate	VB
cord-006860-a3b8hyyr	1546	6	the	the	DT
cord-006860-a3b8hyyr	1546	7	receptors	receptor	NNS
cord-006860-a3b8hyyr	1546	8	for	for	IN
cord-006860-a3b8hyyr	1546	9	histamine	histamine	NN
cord-006860-a3b8hyyr	1546	10	and	and	CC
cord-006860-a3b8hyyr	1546	11	serotonin	serotonin	NN
cord-006860-a3b8hyyr	1546	12	induced	induce	VBN
cord-006860-a3b8hyyr	1546	13	vWf	vWf	NNS
cord-006860-a3b8hyyr	1546	14	release	release	NN
cord-006860-a3b8hyyr	1546	15	.	.	.
cord-006860-a3b8hyyr	1547	1	Absolutely	absolutely	RB
cord-006860-a3b8hyyr	1547	2	unexpected	unexpected	JJ
cord-006860-a3b8hyyr	1547	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	1547	4	do	do	VBP
cord-006860-a3b8hyyr	1547	5	n't	not	RB
cord-006860-a3b8hyyr	1547	6	found	find	VBN
cord-006860-a3b8hyyr	1547	7	any	any	DT
cord-006860-a3b8hyyr	1547	8	significant	significant	JJ
cord-006860-a3b8hyyr	1547	9	vWf	vWf	NNS
cord-006860-a3b8hyyr	1547	10	release	release	NN
cord-006860-a3b8hyyr	1547	11	after	after	IN
cord-006860-a3b8hyyr	1547	12	the	the	DT
cord-006860-a3b8hyyr	1547	13	addition	addition	NN
cord-006860-a3b8hyyr	1547	14	of	of	IN
cord-006860-a3b8hyyr	1547	15	serotonin	serotonin	NN
cord-006860-a3b8hyyr	1547	16	to	to	IN
cord-006860-a3b8hyyr	1547	17	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	1547	18	or	or	CC
cord-006860-a3b8hyyr	1547	19	human	human	JJ
cord-006860-a3b8hyyr	1547	20	artery	artery	NN
cord-006860-a3b8hyyr	1547	21	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1547	22	cells	cell	NNS
cord-006860-a3b8hyyr	1547	23	(	(	-LRB-
cord-006860-a3b8hyyr	1547	24	HUAEC	HUAEC	NNP
cord-006860-a3b8hyyr	1547	25	)	)	-RRB-
cord-006860-a3b8hyyr	1547	26	in	in	IN
cord-006860-a3b8hyyr	1547	27	concentrations	concentration	NNS
cord-006860-a3b8hyyr	1547	28	from	from	IN
cord-006860-a3b8hyyr	1547	29	0.1	0.1	CD
cord-006860-a3b8hyyr	1547	30	IJM	IJM	NNP
cord-006860-a3b8hyyr	1547	31	to	to	IN
cord-006860-a3b8hyyr	1547	32	50	50	CD
cord-006860-a3b8hyyr	1547	33	pM.	pm.	NN
cord-006860-a3b8hyyr	1548	1	In	in	IN
cord-006860-a3b8hyyr	1548	2	the	the	DT
cord-006860-a3b8hyyr	1548	3	case	case	NN
cord-006860-a3b8hyyr	1548	4	of	of	IN
cord-006860-a3b8hyyr	1548	5	histamine	histamine	NN
cord-006860-a3b8hyyr	1548	6	(	(	-LRB-
cord-006860-a3b8hyyr	1548	7	0.1	0.1	CD
cord-006860-a3b8hyyr	1548	8	pM	pm	NN
cord-006860-a3b8hyyr	1548	9	-50	-50	NN
cord-006860-a3b8hyyr	1548	10	pM	pm	NN
cord-006860-a3b8hyyr	1548	11	)	)	-RRB-
cord-006860-a3b8hyyr	1549	1	we	-PRON-	PRP
cord-006860-a3b8hyyr	1549	2	measured	measure	VBD
cord-006860-a3b8hyyr	1549	3	a	a	DT
cord-006860-a3b8hyyr	1549	4	vWf	vWf	NNS
cord-006860-a3b8hyyr	1549	5	release	release	NN
cord-006860-a3b8hyyr	1549	6	2	2	CD
cord-006860-a3b8hyyr	1549	7	-	-	SYM
cord-006860-a3b8hyyr	1549	8	5	5	CD
cord-006860-a3b8hyyr	1549	9	fold	fold	NN
cord-006860-a3b8hyyr	1549	10	compared	compare	VBN
cord-006860-a3b8hyyr	1549	11	to	to	IN
cord-006860-a3b8hyyr	1549	12	unstimulated	unstimulated	JJ
cord-006860-a3b8hyyr	1549	13	cells	cell	NNS
cord-006860-a3b8hyyr	1549	14	.	.	.
cord-006860-a3b8hyyr	1550	1	This	this	DT
cord-006860-a3b8hyyr	1550	2	release	release	NN
cord-006860-a3b8hyyr	1550	3	was	be	VBD
cord-006860-a3b8hyyr	1550	4	in	in	IN
cord-006860-a3b8hyyr	1550	5	the	the	DT
cord-006860-a3b8hyyr	1550	6	same	same	JJ
cord-006860-a3b8hyyr	1550	7	order	order	NN
cord-006860-a3b8hyyr	1550	8	of	of	IN
cord-006860-a3b8hyyr	1550	9	magnitude	magnitude	NN
cord-006860-a3b8hyyr	1550	10	as	as	IN
cord-006860-a3b8hyyr	1550	11	the	the	DT
cord-006860-a3b8hyyr	1550	12	release	release	NN
cord-006860-a3b8hyyr	1550	13	induced	induce	VBN
cord-006860-a3b8hyyr	1550	14	with	with	IN
cord-006860-a3b8hyyr	1550	15	11U	11u	CD
cord-006860-a3b8hyyr	1550	16	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1550	17	.	.	.
cord-006860-a3b8hyyr	1551	1	To	to	TO
cord-006860-a3b8hyyr	1551	2	verify	verify	VB
cord-006860-a3b8hyyr	1551	3	these	these	DT
cord-006860-a3b8hyyr	1551	4	results	result	NNS
cord-006860-a3b8hyyr	1551	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	1551	6	measured	measure	VBD
cord-006860-a3b8hyyr	1551	7	the	the	DT
cord-006860-a3b8hyyr	1551	8	effect	effect	NN
cord-006860-a3b8hyyr	1551	9	of	of	IN
cord-006860-a3b8hyyr	1551	10	histamine	histamine	NN
cord-006860-a3b8hyyr	1551	11	and	and	CC
cord-006860-a3b8hyyr	1551	12	serotonin	serotonin	NN
cord-006860-a3b8hyyr	1551	13	on	on	IN
cord-006860-a3b8hyyr	1551	14	the	the	DT
cord-006860-a3b8hyyr	1551	15	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	1551	16	Ca	Ca	NNP
cord-006860-a3b8hyyr	1551	17	2÷	2÷	CD
cord-006860-a3b8hyyr	1551	18	concentration	concentration	NN
cord-006860-a3b8hyyr	1551	19	(	(	-LRB-
cord-006860-a3b8hyyr	1551	20	Ca~	Ca~	NNP
cord-006860-a3b8hyyr	1551	21	2÷	2÷	CD
cord-006860-a3b8hyyr	1551	22	)	)	-RRB-
cord-006860-a3b8hyyr	1551	23	in	in	IN
cord-006860-a3b8hyyr	1551	24	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	1551	25	and	and	CC
cord-006860-a3b8hyyr	1551	26	HUAEC	HUAEC	NNP
cord-006860-a3b8hyyr	1551	27	.	.	.
cord-006860-a3b8hyyr	1552	1	Cells	cell	NNS
cord-006860-a3b8hyyr	1552	2	were	be	VBD
cord-006860-a3b8hyyr	1552	3	labelled	label	VBN
cord-006860-a3b8hyyr	1552	4	with	with	IN
cord-006860-a3b8hyyr	1552	5	FURA-2	FURA-2	NNP
cord-006860-a3b8hyyr	1552	6	and	and	CC
cord-006860-a3b8hyyr	1552	7	the	the	DT
cord-006860-a3b8hyyr	1552	8	change	change	NN
cord-006860-a3b8hyyr	1552	9	in	in	IN
cord-006860-a3b8hyyr	1552	10	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	1552	11	after	after	IN
cord-006860-a3b8hyyr	1552	12	agonist	agonist	NN
cord-006860-a3b8hyyr	1552	13	addition	addition	NN
cord-006860-a3b8hyyr	1552	14	was	be	VBD
cord-006860-a3b8hyyr	1552	15	measured	measure	VBN
cord-006860-a3b8hyyr	1552	16	with	with	IN
cord-006860-a3b8hyyr	1552	17	a	a	DT
cord-006860-a3b8hyyr	1552	18	microscope	microscope	NN
cord-006860-a3b8hyyr	1552	19	fluorometer	fluorometer	NN
cord-006860-a3b8hyyr	1552	20	.	.	.
cord-006860-a3b8hyyr	1553	1	Using	use	VBG
cord-006860-a3b8hyyr	1553	2	the	the	DT
cord-006860-a3b8hyyr	1553	3	same	same	JJ
cord-006860-a3b8hyyr	1553	4	agonist	agonist	NN
cord-006860-a3b8hyyr	1553	5	concentrations	concentration	NNS
cord-006860-a3b8hyyr	1553	6	as	as	IN
cord-006860-a3b8hyyr	1553	7	above	above	IN
cord-006860-a3b8hyyr	1553	8	we	-PRON-	PRP
cord-006860-a3b8hyyr	1553	9	found	find	VBD
cord-006860-a3b8hyyr	1553	10	an	an	DT
cord-006860-a3b8hyyr	1553	11	5	5	CD
cord-006860-a3b8hyyr	1553	12	-	-	SYM
cord-006860-a3b8hyyr	1553	13	10	10	CD
cord-006860-a3b8hyyr	1553	14	fold	fold	JJ
cord-006860-a3b8hyyr	1553	15	increase	increase	NN
cord-006860-a3b8hyyr	1553	16	of	of	IN
cord-006860-a3b8hyyr	1553	17	Caj	Caj	NNP
cord-006860-a3b8hyyr	1553	18	2	2	CD
cord-006860-a3b8hyyr	1553	19	.	.	.
cord-006860-a3b8hyyr	1554	1	with	with	IN
cord-006860-a3b8hyyr	1554	2	histamine	histamine	NN
cord-006860-a3b8hyyr	1554	3	or	or	CC
cord-006860-a3b8hyyr	1554	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1555	1	but	but	CC
cord-006860-a3b8hyyr	1555	2	no	no	DT
cord-006860-a3b8hyyr	1555	3	effect	effect	NN
cord-006860-a3b8hyyr	1555	4	by	by	IN
cord-006860-a3b8hyyr	1555	5	addition	addition	NN
cord-006860-a3b8hyyr	1555	6	of	of	IN
cord-006860-a3b8hyyr	1555	7	serotonin	serotonin	NN
cord-006860-a3b8hyyr	1555	8	.	.	.
cord-006860-a3b8hyyr	1556	1	This	this	DT
cord-006860-a3b8hyyr	1556	2	results	result	NNS
cord-006860-a3b8hyyr	1556	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	1556	4	a	a	DT
cord-006860-a3b8hyyr	1556	5	similar	similar	JJ
cord-006860-a3b8hyyr	1556	6	activation	activation	NN
cord-006860-a3b8hyyr	1556	7	of	of	IN
cord-006860-a3b8hyyr	1556	8	human	human	JJ
cord-006860-a3b8hyyr	1556	9	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1556	10	cells	cell	NNS
cord-006860-a3b8hyyr	1556	11	by	by	IN
cord-006860-a3b8hyyr	1556	12	histamine	histamine	NN
cord-006860-a3b8hyyr	1556	13	and	and	CC
cord-006860-a3b8hyyr	1556	14	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1556	15	and	and	CC
cord-006860-a3b8hyyr	1556	16	that	that	IN
cord-006860-a3b8hyyr	1556	17	serotonin	serotonin	NN
cord-006860-a3b8hyyr	1556	18	do	do	VBP
cord-006860-a3b8hyyr	1556	19	n't	not	RB
cord-006860-a3b8hyyr	1556	20	stimulate	stimulate	VB
cord-006860-a3b8hyyr	1556	21	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1556	22	vWf	vWf	NNS
cord-006860-a3b8hyyr	1556	23	release	release	NN
cord-006860-a3b8hyyr	1556	24	or	or	CC
cord-006860-a3b8hyyr	1556	25	increase	increase	NN
cord-006860-a3b8hyyr	1556	26	of	of	IN
cord-006860-a3b8hyyr	1556	27	Cay	Cay	NNP
cord-006860-a3b8hyyr	1556	28	.	.	.
cord-006860-a3b8hyyr	1557	1	Activation	activation	NN
cord-006860-a3b8hyyr	1557	2	and/or	and/or	CC
cord-006860-a3b8hyyr	1557	3	dysfunction	dysfunction	NN
cord-006860-a3b8hyyr	1557	4	of	of	IN
cord-006860-a3b8hyyr	1557	5	the	the	DT
cord-006860-a3b8hyyr	1557	6	endothelium	endothelium	NN
cord-006860-a3b8hyyr	1557	7	can	can	MD
cord-006860-a3b8hyyr	1557	8	be	be	VB
cord-006860-a3b8hyyr	1557	9	triggered	trigger	VBN
cord-006860-a3b8hyyr	1557	10	by	by	IN
cord-006860-a3b8hyyr	1557	11	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	1557	12	(	(	-LRB-
cord-006860-a3b8hyyr	1557	13	e.g.	e.g.	RB
cord-006860-a3b8hyyr	1557	14	interleukin-2	interleukin-2	IN
cord-006860-a3b8hyyr	1557	15	,	,	,
cord-006860-a3b8hyyr	1557	16	tumor	tumor	NN
cord-006860-a3b8hyyr	1557	17	necrosis	necrosis	NN
cord-006860-a3b8hyyr	1557	18	factor	factor	NN
cord-006860-a3b8hyyr	1557	19	-	-	HYPH
cord-006860-a3b8hyyr	1557	20	alpha	alpha	NN
cord-006860-a3b8hyyr	1557	21	)	)	-RRB-
cord-006860-a3b8hyyr	1557	22	or	or	CC
cord-006860-a3b8hyyr	1557	23	bacterial	bacterial	JJ
cord-006860-a3b8hyyr	1557	24	substances	substance	NNS
cord-006860-a3b8hyyr	1557	25	(	(	-LRB-
cord-006860-a3b8hyyr	1557	26	e.g.	e.g.	IN
cord-006860-a3b8hyyr	1557	27	endotoxins	endotoxin	NNS
cord-006860-a3b8hyyr	1557	28	)	)	-RRB-
cord-006860-a3b8hyyr	1557	29	and	and	CC
cord-006860-a3b8hyyr	1557	30	may	may	MD
cord-006860-a3b8hyyr	1557	31	contribute	contribute	VB
cord-006860-a3b8hyyr	1557	32	to	to	IN
cord-006860-a3b8hyyr	1557	33	shock	shock	NN
cord-006860-a3b8hyyr	1557	34	and	and	CC
cord-006860-a3b8hyyr	1557	35	multi	multi	JJ
cord-006860-a3b8hyyr	1557	36	organ	organ	NN
cord-006860-a3b8hyyr	1557	37	failure	failure	NN
cord-006860-a3b8hyyr	1557	38	.	.	.
cord-006860-a3b8hyyr	1558	1	PAl	PAl	NNP
cord-006860-a3b8hyyr	1558	2	-	-	HYPH
cord-006860-a3b8hyyr	1558	3	l	l	NN
cord-006860-a3b8hyyr	1558	4	and	and	CC
cord-006860-a3b8hyyr	1558	5	TM	TM	NNP
cord-006860-a3b8hyyr	1558	6	were	be	VBD
cord-006860-a3b8hyyr	1558	7	assessed	assess	VBN
cord-006860-a3b8hyyr	1558	8	as	as	IN
cord-006860-a3b8hyyr	1558	9	parameters	parameter	NNS
cord-006860-a3b8hyyr	1558	10	of	of	IN
cord-006860-a3b8hyyr	1558	11	activated	activate	VBN
cord-006860-a3b8hyyr	1558	12	endothelium	endothelium	NN
cord-006860-a3b8hyyr	1558	13	following	follow	VBG
cord-006860-a3b8hyyr	1558	14	BSCT	BSCT	NNP
cord-006860-a3b8hyyr	1558	15	in	in	IN
cord-006860-a3b8hyyr	1558	16	three	three	CD
cord-006860-a3b8hyyr	1558	17	to	to	TO
cord-006860-a3b8hyyr	1558	18	four	four	CD
cord-006860-a3b8hyyr	1558	19	days	day	NNS
cord-006860-a3b8hyyr	1558	20	intervals	interval	NNS
cord-006860-a3b8hyyr	1558	21	from	from	IN
cord-006860-a3b8hyyr	1558	22	start	start	NN
cord-006860-a3b8hyyr	1558	23	of	of	IN
cord-006860-a3b8hyyr	1558	24	conditioning	conditioning	NN
cord-006860-a3b8hyyr	1558	25	therapy	therapy	NN
cord-006860-a3b8hyyr	1558	26	through	through	IN
cord-006860-a3b8hyyr	1558	27	day	day	NN
cord-006860-a3b8hyyr	1558	28	+35	+35	NNP
cord-006860-a3b8hyyr	1558	29	.	.	.
cord-006860-a3b8hyyr	1559	1	Data	datum	NNS
cord-006860-a3b8hyyr	1559	2	were	be	VBD
cord-006860-a3b8hyyr	1559	3	compared	compare	VBN
cord-006860-a3b8hyyr	1559	4	to	to	IN
cord-006860-a3b8hyyr	1559	5	the	the	DT
cord-006860-a3b8hyyr	1559	6	occurrence	occurrence	NN
cord-006860-a3b8hyyr	1559	7	of	of	IN
cord-006860-a3b8hyyr	1559	8	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1559	9	,	,	,
cord-006860-a3b8hyyr	1559	10	veno	veno	NNP
cord-006860-a3b8hyyr	1559	11	-	-	HYPH
cord-006860-a3b8hyyr	1559	12	occlusive	occlusive	JJ
cord-006860-a3b8hyyr	1559	13	disease	disease	NN
cord-006860-a3b8hyyr	1559	14	(	(	-LRB-
cord-006860-a3b8hyyr	1559	15	VOD	VOD	NNP
cord-006860-a3b8hyyr	1559	16	)	)	-RRB-
cord-006860-a3b8hyyr	1559	17	,	,	,
cord-006860-a3b8hyyr	1559	18	capillary	capillary	JJ
cord-006860-a3b8hyyr	1559	19	leakage	leakage	NN
cord-006860-a3b8hyyr	1559	20	syndrome	syndrome	NN
cord-006860-a3b8hyyr	1559	21	(	(	-LRB-
cord-006860-a3b8hyyr	1559	22	CLS	CLS	NNP
cord-006860-a3b8hyyr	1559	23	)	)	-RRB-
cord-006860-a3b8hyyr	1559	24	and	and	CC
cord-006860-a3b8hyyr	1559	25	graftversus	graftversus	NN
cord-006860-a3b8hyyr	1559	26	-	-	HYPH
cord-006860-a3b8hyyr	1559	27	host	host	NN
cord-006860-a3b8hyyr	1559	28	-	-	HYPH
cord-006860-a3b8hyyr	1559	29	disease	disease	NN
cord-006860-a3b8hyyr	1559	30	(	(	-LRB-
cord-006860-a3b8hyyr	1559	31	GvHD	GvHD	NNP
cord-006860-a3b8hyyr	1559	32	)	)	-RRB-
cord-006860-a3b8hyyr	1559	33	.	.	.
cord-006860-a3b8hyyr	1560	1	Patients	patient	NNS
cord-006860-a3b8hyyr	1560	2	with	with	IN
cord-006860-a3b8hyyr	1560	3	neither	neither	DT
cord-006860-a3b8hyyr	1560	4	complication	complication	NN
cord-006860-a3b8hyyr	1560	5	served	serve	VBD
cord-006860-a3b8hyyr	1560	6	as	as	IN
cord-006860-a3b8hyyr	1560	7	controls	control	NNS
cord-006860-a3b8hyyr	1560	8	.	.	.
cord-006860-a3b8hyyr	1561	1	No	no	UH
cord-006860-a3b8hyyr	1562	1	*	*	NFP
cord-006860-a3b8hyyr	1562	2	days	day	NNS
cord-006860-a3b8hyyr	1562	3	after	after	IN
cord-006860-a3b8hyyr	1562	4	stem	stem	NN
cord-006860-a3b8hyyr	1562	5	cell	cell	NN
cord-006860-a3b8hyyr	1562	6	tranplantation	tranplantation	NN
cord-006860-a3b8hyyr	1562	7	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	1562	8	and	and	CC
cord-006860-a3b8hyyr	1562	9	TM	TM	NNP
cord-006860-a3b8hyyr	1562	10	were	be	VBD
cord-006860-a3b8hyyr	1562	11	increased	increase	VBN
cord-006860-a3b8hyyr	1562	12	in	in	IN
cord-006860-a3b8hyyr	1562	13	all	all	DT
cord-006860-a3b8hyyr	1562	14	patients	patient	NNS
cord-006860-a3b8hyyr	1562	15	with	with	IN
cord-006860-a3b8hyyr	1562	16	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1562	17	,	,	,
cord-006860-a3b8hyyr	1562	18	CLS~	CLS~	NNP
cord-006860-a3b8hyyr	1562	19	VOD	VOD	NNP
cord-006860-a3b8hyyr	1562	20	and/or	and/or	CC
cord-006860-a3b8hyyr	1562	21	GvHD	GvHD	NNP
cord-006860-a3b8hyyr	1562	22	.	.	.
cord-006860-a3b8hyyr	1563	1	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	1563	2	peaked	peak	VBD
cord-006860-a3b8hyyr	1563	3	at	at	IN
cord-006860-a3b8hyyr	1563	4	days	day	NNS
cord-006860-a3b8hyyr	1563	5	14	14	CD
cord-006860-a3b8hyyr	1563	6	to	to	TO
cord-006860-a3b8hyyr	1563	7	18	18	CD
cord-006860-a3b8hyyr	1563	8	and	and	CC
cord-006860-a3b8hyyr	1563	9	the	the	DT
cord-006860-a3b8hyyr	1563	10	increase	increase	NN
cord-006860-a3b8hyyr	1563	11	was	be	VBD
cord-006860-a3b8hyyr	1563	12	highest	high	JJS
cord-006860-a3b8hyyr	1563	13	in	in	IN
cord-006860-a3b8hyyr	1563	14	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1563	15	and	and	CC
cord-006860-a3b8hyyr	1563	16	lowest	low	JJS
cord-006860-a3b8hyyr	1563	17	in	in	IN
cord-006860-a3b8hyyr	1563	18	CLS	CLS	NNP
cord-006860-a3b8hyyr	1563	19	.	.	.
cord-006860-a3b8hyyr	1564	1	The	the	DT
cord-006860-a3b8hyyr	1564	2	increase	increase	NN
cord-006860-a3b8hyyr	1564	3	in	in	IN
cord-006860-a3b8hyyr	1564	4	TM	TM	NNP
cord-006860-a3b8hyyr	1564	5	values	value	NNS
cord-006860-a3b8hyyr	1564	6	was	be	VBD
cord-006860-a3b8hyyr	1564	7	somewhat	somewhat	RB
cord-006860-a3b8hyyr	1564	8	delayed	delay	VBN
cord-006860-a3b8hyyr	1564	9	(	(	-LRB-
cord-006860-a3b8hyyr	1564	10	day	day	NN
cord-006860-a3b8hyyr	1564	11	+24	+24	CD
cord-006860-a3b8hyyr	1564	12	)	)	-RRB-
cord-006860-a3b8hyyr	1564	13	and	and	CC
cord-006860-a3b8hyyr	1564	14	was	be	VBD
cord-006860-a3b8hyyr	1564	15	highest	high	JJS
cord-006860-a3b8hyyr	1564	16	in	in	IN
cord-006860-a3b8hyyr	1564	17	VOD	VOD	NNP
cord-006860-a3b8hyyr	1564	18	and	and	CC
cord-006860-a3b8hyyr	1564	19	CLS	CLS	NNP
cord-006860-a3b8hyyr	1564	20	and	and	CC
cord-006860-a3b8hyyr	1564	21	lowest	low	JJS
cord-006860-a3b8hyyr	1564	22	in	in	IN
cord-006860-a3b8hyyr	1564	23	GvHD	GvHD	NNP
cord-006860-a3b8hyyr	1564	24	.	.	.
cord-006860-a3b8hyyr	1565	1	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	1565	2	and	and	CC
cord-006860-a3b8hyyr	1565	3	TM	TM	NNP
cord-006860-a3b8hyyr	1565	4	are	be	VBP
cord-006860-a3b8hyyr	1565	5	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	1565	6	markers	marker	NNS
cord-006860-a3b8hyyr	1565	7	of	of	IN
cord-006860-a3b8hyyr	1565	8	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1565	9	activation	activation	NN
cord-006860-a3b8hyyr	1565	10	in	in	IN
cord-006860-a3b8hyyr	1565	11	sepsis	sepsis	NN
cord-006860-a3b8hyyr	1565	12	,	,	,
cord-006860-a3b8hyyr	1565	13	VOD	VOD	NNP
cord-006860-a3b8hyyr	1565	14	,	,	,
cord-006860-a3b8hyyr	1565	15	CLS	CLS	NNP
cord-006860-a3b8hyyr	1565	16	,	,	,
cord-006860-a3b8hyyr	1565	17	and/or	and/or	CC
cord-006860-a3b8hyyr	1565	18	GvHD	GvHD	NNP
cord-006860-a3b8hyyr	1565	19	,	,	,
cord-006860-a3b8hyyr	1565	20	but	but	CC
cord-006860-a3b8hyyr	1565	21	they	-PRON-	PRP
cord-006860-a3b8hyyr	1565	22	do	do	VBP
cord-006860-a3b8hyyr	1565	23	not	not	RB
cord-006860-a3b8hyyr	1565	24	allow	allow	VB
cord-006860-a3b8hyyr	1565	25	a	a	DT
cord-006860-a3b8hyyr	1565	26	differention	differention	NN
cord-006860-a3b8hyyr	1565	27	between	between	IN
cord-006860-a3b8hyyr	1565	28	these	these	DT
cord-006860-a3b8hyyr	1565	29	complications	complication	NNS
cord-006860-a3b8hyyr	1565	30	.	.	.
cord-006860-a3b8hyyr	1565	31	 	 	_SP
cord-006860-a3b8hyyr	1566	1	Endothelin	Endothelin	NNP
cord-006860-a3b8hyyr	1566	2	(	(	-LRB-
cord-006860-a3b8hyyr	1566	3	ET	ET	NNP
cord-006860-a3b8hyyr	1566	4	)	)	-RRB-
cord-006860-a3b8hyyr	1566	5	is	be	VBZ
cord-006860-a3b8hyyr	1566	6	the	the	DT
cord-006860-a3b8hyyr	1566	7	most	most	RBS
cord-006860-a3b8hyyr	1566	8	potent	potent	JJ
cord-006860-a3b8hyyr	1566	9	vasoconstrictor	vasoconstrictor	NN
cord-006860-a3b8hyyr	1566	10	.	.	.
cord-006860-a3b8hyyr	1567	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1567	2	is	be	VBZ
cord-006860-a3b8hyyr	1567	3	known	know	VBN
cord-006860-a3b8hyyr	1567	4	that	that	IN
cord-006860-a3b8hyyr	1567	5	ET	et	NN
cord-006860-a3b8hyyr	1567	6	plasma	plasma	NN
cord-006860-a3b8hyyr	1567	7	concentration	concentration	NN
cord-006860-a3b8hyyr	1567	8	is	be	VBZ
cord-006860-a3b8hyyr	1567	9	correlated	correlate	VBN
cord-006860-a3b8hyyr	1567	10	with	with	IN
cord-006860-a3b8hyyr	1567	11	a	a	DT
cord-006860-a3b8hyyr	1567	12	poor	poor	JJ
cord-006860-a3b8hyyr	1567	13	prognosis	prognosis	NN
cord-006860-a3b8hyyr	1567	14	in	in	IN
cord-006860-a3b8hyyr	1567	15	patients	patient	NNS
cord-006860-a3b8hyyr	1567	16	with	with	IN
cord-006860-a3b8hyyr	1567	17	non	non	JJ
cord-006860-a3b8hyyr	1567	18	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	1567	19	cardiomyopathy	cardiomyopathy	NN
cord-006860-a3b8hyyr	1567	20	(	(	-LRB-
cord-006860-a3b8hyyr	1567	21	CM	CM	NNP
cord-006860-a3b8hyyr	1567	22	)	)	-RRB-
cord-006860-a3b8hyyr	1567	23	.	.	.
cord-006860-a3b8hyyr	1568	1	The	the	DT
cord-006860-a3b8hyyr	1568	2	contribution	contribution	NN
cord-006860-a3b8hyyr	1568	3	of	of	IN
cord-006860-a3b8hyyr	1568	4	the	the	DT
cord-006860-a3b8hyyr	1568	5	heart	heart	NN
cord-006860-a3b8hyyr	1568	6	to	to	IN
cord-006860-a3b8hyyr	1568	7	the	the	DT
cord-006860-a3b8hyyr	1568	8	production	production	NN
cord-006860-a3b8hyyr	1568	9	of	of	IN
cord-006860-a3b8hyyr	1568	10	ET	ET	NNP
cord-006860-a3b8hyyr	1568	11	is	be	VBZ
cord-006860-a3b8hyyr	1568	12	still	still	RB
cord-006860-a3b8hyyr	1568	13	unknown	unknown	JJ
cord-006860-a3b8hyyr	1568	14	.	.	.
cord-006860-a3b8hyyr	1569	1	To	to	TO
cord-006860-a3b8hyyr	1569	2	investigate	investigate	VB
cord-006860-a3b8hyyr	1569	3	the	the	DT
cord-006860-a3b8hyyr	1569	4	pathogenetic	pathogenetic	JJ
cord-006860-a3b8hyyr	1569	5	mechanism	mechanism	NN
cord-006860-a3b8hyyr	1569	6	in	in	IN
cord-006860-a3b8hyyr	1569	7	patients	patient	NNS
cord-006860-a3b8hyyr	1569	8	without	without	IN
cord-006860-a3b8hyyr	1569	9	coronary	coronary	JJ
cord-006860-a3b8hyyr	1569	10	artery	artery	NN
cord-006860-a3b8hyyr	1569	11	disease	disease	NN
cord-006860-a3b8hyyr	1569	12	(	(	-LRB-
cord-006860-a3b8hyyr	1569	13	CAD	CAD	NNP
cord-006860-a3b8hyyr	1569	14	)	)	-RRB-
cord-006860-a3b8hyyr	1569	15	,	,	,
cord-006860-a3b8hyyr	1569	16	we	-PRON-	PRP
cord-006860-a3b8hyyr	1569	17	examined	examine	VBD
cord-006860-a3b8hyyr	1569	18	13	13	CD
cord-006860-a3b8hyyr	1569	19	patients	patient	NNS
cord-006860-a3b8hyyr	1569	20	with	with	IN
cord-006860-a3b8hyyr	1569	21	hypertension	hypertension	NN
cord-006860-a3b8hyyr	1569	22	(	(	-LRB-
cord-006860-a3b8hyyr	1569	23	.	.	.
cord-006860-a3b8hyyr	1570	1	Pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	1570	2	capillary	capillary	JJ
cord-006860-a3b8hyyr	1570	3	wedge	wedge	NN
cord-006860-a3b8hyyr	1570	4	pressure	pressure	NN
cord-006860-a3b8hyyr	1570	5	(	(	-LRB-
cord-006860-a3b8hyyr	1570	6	PCWP	PCWP	NNP
cord-006860-a3b8hyyr	1570	7	)	)	-RRB-
cord-006860-a3b8hyyr	1570	8	was	be	VBD
cord-006860-a3b8hyyr	1570	9	measured	measure	VBN
cord-006860-a3b8hyyr	1570	10	in	in	IN
cord-006860-a3b8hyyr	1570	11	all	all	DT
cord-006860-a3b8hyyr	1570	12	patients	patient	NNS
cord-006860-a3b8hyyr	1570	13	.	.	.
cord-006860-a3b8hyyr	1571	1	ET	ET	NNP
cord-006860-a3b8hyyr	1571	2	and	and	CC
cord-006860-a3b8hyyr	1571	3	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1571	4	precursor	precursor	NN
cord-006860-a3b8hyyr	1571	5	big	big	JJ
cord-006860-a3b8hyyr	1571	6	-	-	HYPH
cord-006860-a3b8hyyr	1571	7	endothelin	endothelin	NN
cord-006860-a3b8hyyr	1571	8	(	(	-LRB-
cord-006860-a3b8hyyr	1571	9	BET	bet	RB
cord-006860-a3b8hyyr	1571	10	)	)	-RRB-
cord-006860-a3b8hyyr	1571	11	were	be	VBD
cord-006860-a3b8hyyr	1571	12	determined	determine	VBN
cord-006860-a3b8hyyr	1571	13	at	at	IN
cord-006860-a3b8hyyr	1571	14	rest	rest	NN
cord-006860-a3b8hyyr	1571	15	and	and	CC
cord-006860-a3b8hyyr	1571	16	after	after	IN
cord-006860-a3b8hyyr	1571	17	pharmacological	pharmacological	JJ
cord-006860-a3b8hyyr	1571	18	stimulation	stimulation	NN
cord-006860-a3b8hyyr	1571	19	with	with	IN
cord-006860-a3b8hyyr	1571	20	dipyridamole	dipyridamole	NNP
cord-006860-a3b8hyyr	1571	21	(	(	-LRB-
cord-006860-a3b8hyyr	1571	22	0.5	0.5	CD
cord-006860-a3b8hyyr	1571	23	mg	mg	NNP
cord-006860-a3b8hyyr	1571	24	/	/	SYM
cord-006860-a3b8hyyr	1571	25	kg	kg	NN
cord-006860-a3b8hyyr	1571	26	body	body	NN
cord-006860-a3b8hyyr	1571	27	weight	weight	NN
cord-006860-a3b8hyyr	1571	28	)	)	-RRB-
cord-006860-a3b8hyyr	1571	29	,	,	,
cord-006860-a3b8hyyr	1571	30	that	that	WDT
cord-006860-a3b8hyyr	1571	31	increases	increase	VBZ
cord-006860-a3b8hyyr	1571	32	coronary	coronary	JJ
cord-006860-a3b8hyyr	1571	33	blood	blood	NN
cord-006860-a3b8hyyr	1571	34	flow	flow	NN
cord-006860-a3b8hyyr	1571	35	by	by	IN
cord-006860-a3b8hyyr	1571	36	factor	factor	NN
cord-006860-a3b8hyyr	1571	37	2	2	CD
cord-006860-a3b8hyyr	1571	38	-4	-4	NNS
cord-006860-a3b8hyyr	1571	39	on	on	IN
cord-006860-a3b8hyyr	1571	40	a	a	DT
cord-006860-a3b8hyyr	1571	41	non	non	JJ
cord-006860-a3b8hyyr	1571	42	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1571	43	pathway	pathway	NN
cord-006860-a3b8hyyr	1571	44	.	.	.
cord-006860-a3b8hyyr	1572	1	Cardiac	cardiac	JJ
cord-006860-a3b8hyyr	1572	2	coronary	coronary	NN
cord-006860-a3b8hyyr	1572	3	ET	et	NN
cord-006860-a3b8hyyr	1572	4	and	and	CC
cord-006860-a3b8hyyr	1572	5	BET	bet	NN
cord-006860-a3b8hyyr	1572	6	concentrations	concentration	NNS
cord-006860-a3b8hyyr	1572	7	were	be	VBD
cord-006860-a3b8hyyr	1572	8	determined	determine	VBN
cord-006860-a3b8hyyr	1572	9	from	from	IN
cord-006860-a3b8hyyr	1572	10	the	the	DT
cord-006860-a3b8hyyr	1572	11	arterial	arterial	JJ
cord-006860-a3b8hyyr	1572	12	blood	blood	NN
cord-006860-a3b8hyyr	1572	13	samples	sample	NNS
cord-006860-a3b8hyyr	1572	14	,	,	,
cord-006860-a3b8hyyr	1572	15	obtained	obtain	VBN
cord-006860-a3b8hyyr	1572	16	from	from	IN
cord-006860-a3b8hyyr	1572	17	the	the	DT
cord-006860-a3b8hyyr	1572	18	aorta	aorta	NN
cord-006860-a3b8hyyr	1572	19	,	,	,
cord-006860-a3b8hyyr	1572	20	and	and	CC
cord-006860-a3b8hyyr	1572	21	simultaneously	simultaneously	RB
cord-006860-a3b8hyyr	1572	22	from	from	IN
cord-006860-a3b8hyyr	1572	23	the	the	DT
cord-006860-a3b8hyyr	1572	24	coronary	coronary	JJ
cord-006860-a3b8hyyr	1572	25	sinus	sinus	NN
cord-006860-a3b8hyyr	1572	26	(	(	-LRB-
cord-006860-a3b8hyyr	1572	27	venous	venous	JJ
cord-006860-a3b8hyyr	1572	28	blood	blood	NN
cord-006860-a3b8hyyr	1572	29	)	)	-RRB-
cord-006860-a3b8hyyr	1572	30	.	.	.
cord-006860-a3b8hyyr	1573	1	Blood	blood	NN
cord-006860-a3b8hyyr	1573	2	samples	sample	NNS
cord-006860-a3b8hyyr	1573	3	were	be	VBD
cord-006860-a3b8hyyr	1573	4	collected	collect	VBN
cord-006860-a3b8hyyr	1573	5	into	into	IN
cord-006860-a3b8hyyr	1573	6	ice	ice	NN
cord-006860-a3b8hyyr	1573	7	chilled	chill	VBN
cord-006860-a3b8hyyr	1573	8	Vacutainer	Vacutainer	NNP
cord-006860-a3b8hyyr	1573	9	tubes	tube	NNS
cord-006860-a3b8hyyr	1573	10	and	and	CC
cord-006860-a3b8hyyr	1573	11	stored	store	VBN
cord-006860-a3b8hyyr	1573	12	after	after	IN
cord-006860-a3b8hyyr	1573	13	centrifugation	centrifugation	NN
cord-006860-a3b8hyyr	1573	14	at	at	IN
cord-006860-a3b8hyyr	1573	15	-70	-70	NN
cord-006860-a3b8hyyr	1573	16	*	*	NFP
cord-006860-a3b8hyyr	1573	17	C.	C.	NNP
cord-006860-a3b8hyyr	1573	18	ET	ET	NNP
cord-006860-a3b8hyyr	1573	19	and	and	CC
cord-006860-a3b8hyyr	1573	20	BET	BET	NNP
cord-006860-a3b8hyyr	1573	21	were	be	VBD
cord-006860-a3b8hyyr	1573	22	analysed	analyse	VBN
cord-006860-a3b8hyyr	1573	23	after	after	IN
cord-006860-a3b8hyyr	1573	24	extraction	extraction	NN
cord-006860-a3b8hyyr	1573	25	by	by	IN
cord-006860-a3b8hyyr	1573	26	a	a	DT
cord-006860-a3b8hyyr	1573	27	SePal	SePal	NNP
cord-006860-a3b8hyyr	1573	28	<	<	XX
cord-006860-a3b8hyyr	1573	29	C	C	NNP
cord-006860-a3b8hyyr	1573	30	18	18	CD
cord-006860-a3b8hyyr	1573	31	cartridge	cartridge	NN
cord-006860-a3b8hyyr	1573	32	by	by	IN
cord-006860-a3b8hyyr	1573	33	radio	radio	NN
cord-006860-a3b8hyyr	1573	34	immuno	immuno	JJ
cord-006860-a3b8hyyr	1573	35	assay	assay	NN
cord-006860-a3b8hyyr	1573	36	technique	technique	NN
cord-006860-a3b8hyyr	1573	37	(	(	-LRB-
cord-006860-a3b8hyyr	1573	38	Immundiagnostik	Immundiagnostik	NNP
cord-006860-a3b8hyyr	1573	39	)	)	-RRB-
cord-006860-a3b8hyyr	1573	40	.	.	.
cord-006860-a3b8hyyr	1574	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1574	2	is	be	VBZ
cord-006860-a3b8hyyr	1574	3	concluded	conclude	VBN
cord-006860-a3b8hyyr	1574	4	that	that	IN
cord-006860-a3b8hyyr	1574	5	ET	ET	NNP
cord-006860-a3b8hyyr	1574	6	is	be	VBZ
cord-006860-a3b8hyyr	1574	7	increased	increase	VBN
cord-006860-a3b8hyyr	1574	8	with	with	IN
cord-006860-a3b8hyyr	1574	9	elevated	elevated	JJ
cord-006860-a3b8hyyr	1574	10	filling	filling	NN
cord-006860-a3b8hyyr	1574	11	pressures	pressure	NNS
cord-006860-a3b8hyyr	1574	12	of	of	IN
cord-006860-a3b8hyyr	1574	13	the	the	DT
cord-006860-a3b8hyyr	1574	14	heart	heart	NN
cord-006860-a3b8hyyr	1574	15	in	in	IN
cord-006860-a3b8hyyr	1574	16	patients	patient	NNS
cord-006860-a3b8hyyr	1574	17	with	with	IN
cord-006860-a3b8hyyr	1574	18	CM	CM	NNP
cord-006860-a3b8hyyr	1574	19	.	.	.
cord-006860-a3b8hyyr	1575	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1575	2	is	be	VBZ
cord-006860-a3b8hyyr	1575	3	not	not	RB
cord-006860-a3b8hyyr	1575	4	produced	produce	VBN
cord-006860-a3b8hyyr	1575	5	in	in	IN
cord-006860-a3b8hyyr	1575	6	considerable	considerable	JJ
cord-006860-a3b8hyyr	1575	7	quantity	quantity	NN
cord-006860-a3b8hyyr	1575	8	by	by	IN
cord-006860-a3b8hyyr	1575	9	the	the	DT
cord-006860-a3b8hyyr	1575	10	heart	heart	NN
cord-006860-a3b8hyyr	1575	11	neither	neither	CC
cord-006860-a3b8hyyr	1575	12	at	at	IN
cord-006860-a3b8hyyr	1575	13	rest	rest	NN
cord-006860-a3b8hyyr	1575	14	nor	nor	CC
cord-006860-a3b8hyyr	1575	15	at	at	IN
cord-006860-a3b8hyyr	1575	16	increased	increase	VBN
cord-006860-a3b8hyyr	1575	17	blood	blood	NN
cord-006860-a3b8hyyr	1575	18	flow	flow	NN
cord-006860-a3b8hyyr	1575	19	.	.	.
cord-006860-a3b8hyyr	1576	1	There4ore	There4ore	NNP
cord-006860-a3b8hyyr	1576	2	the	the	DT
cord-006860-a3b8hyyr	1576	3	lung	lung	NN
cord-006860-a3b8hyyr	1576	4	has	have	VBZ
cord-006860-a3b8hyyr	1576	5	to	to	TO
cord-006860-a3b8hyyr	1576	6	be	be	VB
cord-006860-a3b8hyyr	1576	7	considered	consider	VBN
cord-006860-a3b8hyyr	1576	8	as	as	IN
cord-006860-a3b8hyyr	1576	9	the	the	DT
cord-006860-a3b8hyyr	1576	10	major	major	JJ
cord-006860-a3b8hyyr	1576	11	organ	organ	NN
cord-006860-a3b8hyyr	1576	12	for	for	IN
cord-006860-a3b8hyyr	1576	13	the	the	DT
cord-006860-a3b8hyyr	1576	14	production	production	NN
cord-006860-a3b8hyyr	1576	15	of	of	IN
cord-006860-a3b8hyyr	1576	16	ET	et	NN
cord-006860-a3b8hyyr	1576	17	and	and	CC
cord-006860-a3b8hyyr	1576	18	BET	bet	VB
cord-006860-a3b8hyyr	1576	19	in	in	IN
cord-006860-a3b8hyyr	1576	20	patients	patient	NNS
cord-006860-a3b8hyyr	1576	21	without	without	IN
cord-006860-a3b8hyyr	1576	22	CAD	CAD	NNP
cord-006860-a3b8hyyr	1576	23	.	.	.
cord-006860-a3b8hyyr	1577	1	To	to	TO
cord-006860-a3b8hyyr	1577	2	characterize	characterize	VB
cord-006860-a3b8hyyr	1577	3	the	the	DT
cord-006860-a3b8hyyr	1577	4	incompatibility	incompatibility	NN
cord-006860-a3b8hyyr	1577	5	of	of	IN
cord-006860-a3b8hyyr	1577	6	blood	blood	NN
cord-006860-a3b8hyyr	1577	7	with	with	IN
cord-006860-a3b8hyyr	1577	8	foreign	foreign	JJ
cord-006860-a3b8hyyr	1577	9	surfaces	surface	NNS
cord-006860-a3b8hyyr	1577	10	valide	valide	FW
cord-006860-a3b8hyyr	1577	11	in	in	FW
cord-006860-a3b8hyyr	1577	12	vitro	vitro	FW
cord-006860-a3b8hyyr	1577	13	methods	method	NNS
cord-006860-a3b8hyyr	1577	14	especially	especially	RB
cord-006860-a3b8hyyr	1577	15	in	in	IN
cord-006860-a3b8hyyr	1577	16	testing	testing	NN
cord-006860-a3b8hyyr	1577	17	of	of	IN
cord-006860-a3b8hyyr	1577	18	platelet	platelet	NN
cord-006860-a3b8hyyr	1577	19	function	function	NN
cord-006860-a3b8hyyr	1577	20	are	be	VBP
cord-006860-a3b8hyyr	1577	21	neceessary	neceessary	JJ
cord-006860-a3b8hyyr	1577	22	.	.	.
cord-006860-a3b8hyyr	1578	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1578	2	seems	seem	VBZ
cord-006860-a3b8hyyr	1578	3	to	to	TO
cord-006860-a3b8hyyr	1578	4	be	be	VB
cord-006860-a3b8hyyr	1578	5	effective	effective	JJ
cord-006860-a3b8hyyr	1578	6	to	to	TO
cord-006860-a3b8hyyr	1578	7	use	use	VB
cord-006860-a3b8hyyr	1578	8	test	test	NN
cord-006860-a3b8hyyr	1578	9	systems	system	NNS
cord-006860-a3b8hyyr	1578	10	which	which	WDT
cord-006860-a3b8hyyr	1578	11	can	can	MD
cord-006860-a3b8hyyr	1578	12	also	also	RB
cord-006860-a3b8hyyr	1578	13	be	be	VB
cord-006860-a3b8hyyr	1578	14	helpful	helpful	JJ
cord-006860-a3b8hyyr	1578	15	lateron	lateron	RB
cord-006860-a3b8hyyr	1578	16	in	in	IN
cord-006860-a3b8hyyr	1578	17	the	the	DT
cord-006860-a3b8hyyr	1578	18	clinic	clinic	NN
cord-006860-a3b8hyyr	1578	19	when	when	WRB
cord-006860-a3b8hyyr	1578	20	foreign	foreign	JJ
cord-006860-a3b8hyyr	1578	21	surfaces	surface	NNS
cord-006860-a3b8hyyr	1578	22	(	(	-LRB-
cord-006860-a3b8hyyr	1578	23	e.g.	e.g.	JJ
cord-006860-a3b8hyyr	1578	24	venous	venous	JJ
cord-006860-a3b8hyyr	1578	25	catheters	catheter	NNS
cord-006860-a3b8hyyr	1578	26	)	)	-RRB-
cord-006860-a3b8hyyr	1578	27	are	be	VBP
cord-006860-a3b8hyyr	1578	28	used	use	VBN
cord-006860-a3b8hyyr	1578	29	and	and	CC
cord-006860-a3b8hyyr	1578	30	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	1578	31	in	in	IN
cord-006860-a3b8hyyr	1578	32	so	so	RB
cord-006860-a3b8hyyr	1578	33	called	call	VBN
cord-006860-a3b8hyyr	1578	34	phase-4-studies	phase-4-studie	NNS
cord-006860-a3b8hyyr	1578	35	.	.	.
cord-006860-a3b8hyyr	1579	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1579	2	studied	study	VBD
cord-006860-a3b8hyyr	1579	3	the	the	DT
cord-006860-a3b8hyyr	1579	4	influence	influence	NN
cord-006860-a3b8hyyr	1579	5	of	of	IN
cord-006860-a3b8hyyr	1579	6	21	21	CD
cord-006860-a3b8hyyr	1579	7	reference	reference	NN
cord-006860-a3b8hyyr	1579	8	polymers	polymer	NNS
cord-006860-a3b8hyyr	1579	9	under	under	IN
cord-006860-a3b8hyyr	1579	10	standardized	standardized	JJ
cord-006860-a3b8hyyr	1579	11	and	and	CC
cord-006860-a3b8hyyr	1579	12	controlled	control	VBN
cord-006860-a3b8hyyr	1579	13	flow	flow	NN
cord-006860-a3b8hyyr	1579	14	conditions	condition	NNS
cord-006860-a3b8hyyr	1579	15	on	on	IN
cord-006860-a3b8hyyr	1579	16	platelets	platelet	NNS
cord-006860-a3b8hyyr	1579	17	in	in	IN
cord-006860-a3b8hyyr	1579	18	citrated	citrate	VBN
cord-006860-a3b8hyyr	1579	19	blood	blood	NN
cord-006860-a3b8hyyr	1579	20	specimen	specimen	NN
cord-006860-a3b8hyyr	1579	21	of	of	IN
cord-006860-a3b8hyyr	1579	22	healthy	healthy	JJ
cord-006860-a3b8hyyr	1579	23	blood	blood	NN
cord-006860-a3b8hyyr	1579	24	donors	donor	NNS
cord-006860-a3b8hyyr	1579	25	.	.	.
cord-006860-a3b8hyyr	1580	1	The	the	DT
cord-006860-a3b8hyyr	1580	2	following	follow	VBG
cord-006860-a3b8hyyr	1580	3	tests	test	NNS
cord-006860-a3b8hyyr	1580	4	were	be	VBD
cord-006860-a3b8hyyr	1580	5	performed	perform	VBN
cord-006860-a3b8hyyr	1580	6	pre	pre	JJ
cord-006860-a3b8hyyr	1580	7	and	and	CC
cord-006860-a3b8hyyr	1580	8	post	post	JJ
cord-006860-a3b8hyyr	1580	9	platelet	platelet	NN
cord-006860-a3b8hyyr	1580	10	-	-	HYPH
cord-006860-a3b8hyyr	1580	11	pol)aner	pol)aner	``
cord-006860-a3b8hyyr	1580	12	contact	contact	NN
cord-006860-a3b8hyyr	1580	13	:	:	:
cord-006860-a3b8hyyr	1580	14	decrease	decrease	NN
cord-006860-a3b8hyyr	1580	15	of	of	IN
cord-006860-a3b8hyyr	1580	16	platelet	platelet	NN
cord-006860-a3b8hyyr	1580	17	count	count	NN
cord-006860-a3b8hyyr	1580	18	,	,	,
cord-006860-a3b8hyyr	1580	19	platelet	platelet	NN
cord-006860-a3b8hyyr	1580	20	aggregation	aggregation	NN
cord-006860-a3b8hyyr	1580	21	(	(	-LRB-
cord-006860-a3b8hyyr	1580	22	Wu	Wu	NNP
cord-006860-a3b8hyyr	1580	23	-	-	HYPH
cord-006860-a3b8hyyr	1580	24	Gmtemeyer	Gmtemeyer	NNP
cord-006860-a3b8hyyr	1580	25	index	index	NN
cord-006860-a3b8hyyr	1580	26	)	)	-RRB-
cord-006860-a3b8hyyr	1580	27	,	,	,
cord-006860-a3b8hyyr	1580	28	analysis	analysis	NN
cord-006860-a3b8hyyr	1580	29	of	of	IN
cord-006860-a3b8hyyr	1580	30	platelet	platelet	NN
cord-006860-a3b8hyyr	1580	31	spreading	spread	VBG
cord-006860-a3b8hyyr	1580	32	capacity	capacity	NN
cord-006860-a3b8hyyr	1580	33	on	on	IN
cord-006860-a3b8hyyr	1580	34	standardized	standardized	JJ
cord-006860-a3b8hyyr	1580	35	plastic	plastic	NN
cord-006860-a3b8hyyr	1580	36	surfaces	surface	NNS
cord-006860-a3b8hyyr	1580	37	by	by	IN
cord-006860-a3b8hyyr	1580	38	using	use	VBG
cord-006860-a3b8hyyr	1580	39	a	a	DT
cord-006860-a3b8hyyr	1580	40	visual	visual	JJ
cord-006860-a3b8hyyr	1580	41	microscopic	microscopic	JJ
cord-006860-a3b8hyyr	1580	42	evaluation	evaluation	NN
cord-006860-a3b8hyyr	1580	43	according	accord	VBG
cord-006860-a3b8hyyr	1580	44	to	to	IN
cord-006860-a3b8hyyr	1580	45	Breddin	Breddin	NNP
cord-006860-a3b8hyyr	1580	46	and	and	CC
cord-006860-a3b8hyyr	1580	47	Bfirck	Bfirck	NNP
cord-006860-a3b8hyyr	1580	48	(	(	-LRB-
cord-006860-a3b8hyyr	1580	49	1963	1963	CD
cord-006860-a3b8hyyr	1580	50	)	)	-RRB-
cord-006860-a3b8hyyr	1580	51	and	and	CC
cord-006860-a3b8hyyr	1580	52	an	an	DT
cord-006860-a3b8hyyr	1580	53	interactive	interactive	JJ
cord-006860-a3b8hyyr	1580	54	computer	computer	NN
cord-006860-a3b8hyyr	1580	55	-	-	HYPH
cord-006860-a3b8hyyr	1580	56	aided	aid	VBN
cord-006860-a3b8hyyr	1580	57	system	system	NN
cord-006860-a3b8hyyr	1580	58	(	(	-LRB-
cord-006860-a3b8hyyr	1580	59	IBAS	IBAS	NNP
cord-006860-a3b8hyyr	1580	60	,	,	,
cord-006860-a3b8hyyr	1580	61	Kontron	Kontron	NNP
cord-006860-a3b8hyyr	1580	62	GmbH	GmbH	NNP
cord-006860-a3b8hyyr	1580	63	,	,	,
cord-006860-a3b8hyyr	1580	64	Manchen	Manchen	NNP
cord-006860-a3b8hyyr	1580	65	,	,	,
cord-006860-a3b8hyyr	1580	66	FRG	FRG	NNP
cord-006860-a3b8hyyr	1580	67	)	)	-RRB-
cord-006860-a3b8hyyr	1580	68	by	by	IN
cord-006860-a3b8hyyr	1580	69	digitalizing	digitalize	VBG
cord-006860-a3b8hyyr	1580	70	the	the	DT
cord-006860-a3b8hyyr	1580	71	morphological	morphological	JJ
cord-006860-a3b8hyyr	1580	72	picture	picture	NN
cord-006860-a3b8hyyr	1580	73	of	of	IN
cord-006860-a3b8hyyr	1580	74	the	the	DT
cord-006860-a3b8hyyr	1580	75	platelet	platelet	NN
cord-006860-a3b8hyyr	1580	76	slides	slide	NNS
cord-006860-a3b8hyyr	1580	77	and	and	CC
cord-006860-a3b8hyyr	1580	78	area	area	NN
cord-006860-a3b8hyyr	1580	79	detection	detection	NN
cord-006860-a3b8hyyr	1580	80	with	with	IN
cord-006860-a3b8hyyr	1580	81	a	a	DT
cord-006860-a3b8hyyr	1580	82	resolution	resolution	NN
cord-006860-a3b8hyyr	1580	83	of	of	IN
cord-006860-a3b8hyyr	1580	84	512x512	512x512	CD
cord-006860-a3b8hyyr	1580	85	pixels	pixel	NNS
cord-006860-a3b8hyyr	1580	86	.	.	.
cord-006860-a3b8hyyr	1581	1	Results	result	NNS
cord-006860-a3b8hyyr	1581	2	:	:	:
cord-006860-a3b8hyyr	1582	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	1582	2	counts	count	NNS
cord-006860-a3b8hyyr	1582	3	showed	show	VBD
cord-006860-a3b8hyyr	1582	4	significant	significant	JJ
cord-006860-a3b8hyyr	1582	5	differences	difference	NNS
cord-006860-a3b8hyyr	1582	6	pre	pre	VBP
cord-006860-a3b8hyyr	1582	7	and	and	CC
cord-006860-a3b8hyyr	1582	8	post	post	VB
cord-006860-a3b8hyyr	1582	9	polymer	polymer	NN
cord-006860-a3b8hyyr	1582	10	contact	contact	NN
cord-006860-a3b8hyyr	1582	11	,	,	,
cord-006860-a3b8hyyr	1582	12	the	the	DT
cord-006860-a3b8hyyr	1582	13	Wu	Wu	NNP
cord-006860-a3b8hyyr	1582	14	-	-	HYPH
cord-006860-a3b8hyyr	1582	15	Grotemeyer	Grotemeyer	NNP
cord-006860-a3b8hyyr	1582	16	index	index	NN
cord-006860-a3b8hyyr	1582	17	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	1582	18	platelet	platelet	NN
cord-006860-a3b8hyyr	1582	19	activation	activation	NN
cord-006860-a3b8hyyr	1582	20	only	only	RB
cord-006860-a3b8hyyr	1582	21	by	by	IN
cord-006860-a3b8hyyr	1582	22	blood	blood	NN
cord-006860-a3b8hyyr	1582	23	contact	contact	NN
cord-006860-a3b8hyyr	1582	24	with	with	IN
cord-006860-a3b8hyyr	1582	25	large	large	JJ
cord-006860-a3b8hyyr	1582	26	volumes	volume	NNS
cord-006860-a3b8hyyr	1582	27	of	of	IN
cord-006860-a3b8hyyr	1582	28	polymeric	polymeric	JJ
cord-006860-a3b8hyyr	1582	29	material	material	NN
cord-006860-a3b8hyyr	1582	30	whereas	whereas	IN
cord-006860-a3b8hyyr	1582	31	both	both	CC
cord-006860-a3b8hyyr	1582	32	visual	visual	JJ
cord-006860-a3b8hyyr	1582	33	and	and	CC
cord-006860-a3b8hyyr	1582	34	computer	computer	NN
cord-006860-a3b8hyyr	1582	35	-	-	HYPH
cord-006860-a3b8hyyr	1582	36	assisted	assist	VBN
cord-006860-a3b8hyyr	1582	37	evaluation	evaluation	NN
cord-006860-a3b8hyyr	1582	38	of	of	IN
cord-006860-a3b8hyyr	1582	39	platelet	platelet	NN
cord-006860-a3b8hyyr	1582	40	spreading	spread	VBG
cord-006860-a3b8hyyr	1582	41	ability	ability	NN
cord-006860-a3b8hyyr	1582	42	revealed	reveal	VBD
cord-006860-a3b8hyyr	1582	43	a	a	DT
cord-006860-a3b8hyyr	1582	44	marked	marked	JJ
cord-006860-a3b8hyyr	1582	45	shift	shift	NN
cord-006860-a3b8hyyr	1582	46	in	in	IN
cord-006860-a3b8hyyr	1582	47	the	the	DT
cord-006860-a3b8hyyr	1582	48	different	different	JJ
cord-006860-a3b8hyyr	1582	49	classes	class	NNS
cord-006860-a3b8hyyr	1582	50	of	of	IN
cord-006860-a3b8hyyr	1582	51	platelets	platelet	NNS
cord-006860-a3b8hyyr	1582	52	:	:	:
cord-006860-a3b8hyyr	1582	53	platelet	platelet	NN
cord-006860-a3b8hyyr	1582	54	activation	activation	NN
cord-006860-a3b8hyyr	1582	55	results	result	NNS
cord-006860-a3b8hyyr	1582	56	in	in	IN
cord-006860-a3b8hyyr	1582	57	a	a	DT
cord-006860-a3b8hyyr	1582	58	decrease	decrease	NN
cord-006860-a3b8hyyr	1582	59	of	of	IN
cord-006860-a3b8hyyr	1582	60	large	large	JJ
cord-006860-a3b8hyyr	1582	61	structural	structural	JJ
cord-006860-a3b8hyyr	1582	62	elements	element	NNS
cord-006860-a3b8hyyr	1582	63	and	and	CC
cord-006860-a3b8hyyr	1582	64	an	an	DT
cord-006860-a3b8hyyr	1582	65	increase	increase	NN
cord-006860-a3b8hyyr	1582	66	of	of	IN
cord-006860-a3b8hyyr	1582	67	elements	element	NNS
cord-006860-a3b8hyyr	1582	68	with	with	IN
cord-006860-a3b8hyyr	1582	69	spider	spider	NN
cord-006860-a3b8hyyr	1582	70	threads	thread	NNS
cord-006860-a3b8hyyr	1582	71	.	.	.
cord-006860-a3b8hyyr	1583	1	(	(	-LRB-
cord-006860-a3b8hyyr	1583	2	Pre	pre	JJ
cord-006860-a3b8hyyr	1583	3	contact	contact	NN
cord-006860-a3b8hyyr	1583	4	(	(	-LRB-
cord-006860-a3b8hyyr	1583	5	n=1000	n=1000	CD
cord-006860-a3b8hyyr	1583	6	)	)	-RRB-
cord-006860-a3b8hyyr	1583	7	:	:	:
cord-006860-a3b8hyyr	1584	1	27:~-6	27:~-6	CD
cord-006860-a3b8hyyr	1584	2	large	large	JJ
cord-006860-a3b8hyyr	1584	3	forms	form	NNS
cord-006860-a3b8hyyr	1584	4	of	of	IN
cord-006860-a3b8hyyr	1584	5	platelets	platelet	NNS
cord-006860-a3b8hyyr	1584	6	,	,	,
cord-006860-a3b8hyyr	1584	7	700~-39	700~-39	CD
cord-006860-a3b8hyyr	1584	8	small	small	JJ
cord-006860-a3b8hyyr	1584	9	forms	form	NNS
cord-006860-a3b8hyyr	1584	10	and	and	CC
cord-006860-a3b8hyyr	1584	11	275	275	CD
cord-006860-a3b8hyyr	1584	12	:	:	:
cord-006860-a3b8hyyr	1584	13	L-41	L-41	NNP
cord-006860-a3b8hyyr	1584	14	spider	spider	NN
cord-006860-a3b8hyyr	1584	15	forms	form	NNS
cord-006860-a3b8hyyr	1584	16	;	;	:
cord-006860-a3b8hyyr	1584	17	post	post	NN
cord-006860-a3b8hyyr	1584	18	contact	contact	NN
cord-006860-a3b8hyyr	1584	19	(	(	-LRB-
cord-006860-a3b8hyyr	1584	20	n=1000	n=1000	CD
cord-006860-a3b8hyyr	1584	21	)	)	-RRB-
cord-006860-a3b8hyyr	1584	22	:	:	:
cord-006860-a3b8hyyr	1585	1	6-+-5	6-+-5	CD
cord-006860-a3b8hyyr	1585	2	large	large	JJ
cord-006860-a3b8hyyr	1585	3	forms	form	NNS
cord-006860-a3b8hyyr	1585	4	,	,	,
cord-006860-a3b8hyyr	1585	5	510a:56	510a:56	CD
cord-006860-a3b8hyyr	1585	6	small	small	JJ
cord-006860-a3b8hyyr	1585	7	forms	form	NNS
cord-006860-a3b8hyyr	1585	8	and	and	CC
cord-006860-a3b8hyyr	1585	9	484±58	484±58	CD
cord-006860-a3b8hyyr	1585	10	platelets	platelet	NNS
cord-006860-a3b8hyyr	1585	11	with	with	IN
cord-006860-a3b8hyyr	1585	12	spider	spider	NN
cord-006860-a3b8hyyr	1585	13	threads	thread	NNS
cord-006860-a3b8hyyr	1585	14	)	)	-RRB-
cord-006860-a3b8hyyr	1585	15	.	.	.
cord-006860-a3b8hyyr	1586	1	In	in	IN
cord-006860-a3b8hyyr	1586	2	some	some	DT
cord-006860-a3b8hyyr	1586	3	series	series	NN
cord-006860-a3b8hyyr	1586	4	there	there	EX
cord-006860-a3b8hyyr	1586	5	were	be	VBD
cord-006860-a3b8hyyr	1586	6	significant	significant	JJ
cord-006860-a3b8hyyr	1586	7	differences	difference	NNS
cord-006860-a3b8hyyr	1586	8	between	between	IN
cord-006860-a3b8hyyr	1586	9	visual	visual	JJ
cord-006860-a3b8hyyr	1586	10	and	and	CC
cord-006860-a3b8hyyr	1586	11	computer	computer	NN
cord-006860-a3b8hyyr	1586	12	-	-	HYPH
cord-006860-a3b8hyyr	1586	13	aided	aid	VBN
cord-006860-a3b8hyyr	1586	14	evaluation	evaluation	NN
cord-006860-a3b8hyyr	1586	15	in	in	IN
cord-006860-a3b8hyyr	1586	16	the	the	DT
cord-006860-a3b8hyyr	1586	17	detection	detection	NN
cord-006860-a3b8hyyr	1586	18	of	of	IN
cord-006860-a3b8hyyr	1586	19	small	small	JJ
cord-006860-a3b8hyyr	1586	20	and	and	CC
cord-006860-a3b8hyyr	1586	21	spider	spider	NN
cord-006860-a3b8hyyr	1586	22	forms	form	NNS
cord-006860-a3b8hyyr	1586	23	.	.	.
cord-006860-a3b8hyyr	1587	1	However	however	RB
cord-006860-a3b8hyyr	1587	2	,	,	,
cord-006860-a3b8hyyr	1587	3	the	the	DT
cord-006860-a3b8hyyr	1587	4	relative	relative	JJ
cord-006860-a3b8hyyr	1587	5	increase	increase	NN
cord-006860-a3b8hyyr	1587	6	of	of	IN
cord-006860-a3b8hyyr	1587	7	these	these	DT
cord-006860-a3b8hyyr	1587	8	nonspread	nonspread	NNP
cord-006860-a3b8hyyr	1587	9	spider	spider	NN
cord-006860-a3b8hyyr	1587	10	forms	form	NNS
cord-006860-a3b8hyyr	1587	11	could	could	MD
cord-006860-a3b8hyyr	1587	12	be	be	VB
cord-006860-a3b8hyyr	1587	13	stated	state	VBN
cord-006860-a3b8hyyr	1587	14	with	with	IN
cord-006860-a3b8hyyr	1587	15	beth	beth	NNP
cord-006860-a3b8hyyr	1587	16	methods	method	NNS
cord-006860-a3b8hyyr	1587	17	(	(	-LRB-
cord-006860-a3b8hyyr	1587	18	Wilcoxon	Wilcoxon	NNP
cord-006860-a3b8hyyr	1587	19	test	test	NN
cord-006860-a3b8hyyr	1587	20	)	)	-RRB-
cord-006860-a3b8hyyr	1587	21	.	.	.
cord-006860-a3b8hyyr	1588	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1588	2	therefore	therefore	RB
cord-006860-a3b8hyyr	1588	3	conclude	conclude	VBP
cord-006860-a3b8hyyr	1588	4	,	,	,
cord-006860-a3b8hyyr	1588	5	that	that	DT
cord-006860-a3b8hyyr	1588	6	platelet	platelet	NN
cord-006860-a3b8hyyr	1588	7	morphometry	morphometry	NN
cord-006860-a3b8hyyr	1588	8	with	with	IN
cord-006860-a3b8hyyr	1588	9	both	both	DT
cord-006860-a3b8hyyr	1588	10	methods	method	NNS
cord-006860-a3b8hyyr	1588	11	is	be	VBZ
cord-006860-a3b8hyyr	1588	12	a	a	DT
cord-006860-a3b8hyyr	1588	13	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	1588	14	and	and	CC
cord-006860-a3b8hyyr	1588	15	reliable	reliable	JJ
cord-006860-a3b8hyyr	1588	16	ex	ex	NN
cord-006860-a3b8hyyr	1588	17	vivo	vivo	NN
cord-006860-a3b8hyyr	1588	18	method	method	NN
cord-006860-a3b8hyyr	1588	19	to	to	TO
cord-006860-a3b8hyyr	1588	20	evaluate	evaluate	VB
cord-006860-a3b8hyyr	1588	21	platelet	platelet	NN
cord-006860-a3b8hyyr	1588	22	interactions	interaction	NNS
cord-006860-a3b8hyyr	1588	23	with	with	IN
cord-006860-a3b8hyyr	1588	24	artificial	artificial	JJ
cord-006860-a3b8hyyr	1588	25	surfaces	surface	NNS
cord-006860-a3b8hyyr	1588	26	and	and	CC
cord-006860-a3b8hyyr	1588	27	can	can	MD
cord-006860-a3b8hyyr	1588	28	also	also	RB
cord-006860-a3b8hyyr	1588	29	be	be	VB
cord-006860-a3b8hyyr	1588	30	used	use	VBN
cord-006860-a3b8hyyr	1588	31	lateron	lateron	RB
cord-006860-a3b8hyyr	1588	32	in	in	IN
cord-006860-a3b8hyyr	1588	33	phase-4-studies	phase-4-studie	NNS
cord-006860-a3b8hyyr	1588	34	in	in	IN
cord-006860-a3b8hyyr	1588	35	patients	patient	NNS
cord-006860-a3b8hyyr	1588	36	.	.	.
cord-006860-a3b8hyyr	1589	1	However	however	RB
cord-006860-a3b8hyyr	1589	2	,	,	,
cord-006860-a3b8hyyr	1589	3	the	the	DT
cord-006860-a3b8hyyr	1589	4	IBAS	IBAS	NNP
cord-006860-a3b8hyyr	1589	5	-	-	HYPH
cord-006860-a3b8hyyr	1589	6	system	system	NN
cord-006860-a3b8hyyr	1589	7	requires	require	VBZ
cord-006860-a3b8hyyr	1589	8	further	further	RB
cord-006860-a3b8hyyr	1589	9	maprovement	maprovement	JJ
cord-006860-a3b8hyyr	1589	10	in	in	IN
cord-006860-a3b8hyyr	1589	11	hard	hard	JJ
cord-006860-a3b8hyyr	1589	12	-	-	:
cord-006860-a3b8hyyr	1589	13	and	and	CC
cord-006860-a3b8hyyr	1589	14	so	so	RB
cord-006860-a3b8hyyr	1589	15	,	,	,
cord-006860-a3b8hyyr	1589	16	ware	ware	NNP
cord-006860-a3b8hyyr	1589	17	to	to	TO
cord-006860-a3b8hyyr	1589	18	reduce	reduce	VB
cord-006860-a3b8hyyr	1589	19	the	the	DT
cord-006860-a3b8hyyr	1589	20	high	high	JJ
cord-006860-a3b8hyyr	1589	21	expenditure	expenditure	NN
cord-006860-a3b8hyyr	1589	22	of	of	IN
cord-006860-a3b8hyyr	1589	23	this	this	DT
cord-006860-a3b8hyyr	1589	24	method	method	NN
cord-006860-a3b8hyyr	1589	25	.	.	.
cord-006860-a3b8hyyr	1590	1	Despite	despite	IN
cord-006860-a3b8hyyr	1590	2	for	for	IN
cord-006860-a3b8hyyr	1590	3	the	the	DT
cord-006860-a3b8hyyr	1590	4	most	most	JJS
cord-006860-a3b8hyyr	1590	5	part	part	NN
cord-006860-a3b8hyyr	1590	6	standardised	standardise	VBN
cord-006860-a3b8hyyr	1590	7	methods	method	NNS
cord-006860-a3b8hyyr	1590	8	such	such	JJ
cord-006860-a3b8hyyr	1590	9	as	as	IN
cord-006860-a3b8hyyr	1590	10	hypothermia	hypothermia	NN
cord-006860-a3b8hyyr	1590	11	,	,	,
cord-006860-a3b8hyyr	1590	12	cardioplegia	cardioplegia	VB
cord-006860-a3b8hyyr	1590	13	the	the	DT
cord-006860-a3b8hyyr	1590	14	perioperative	perioperative	JJ
cord-006860-a3b8hyyr	1590	15	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	1590	16	infartion	infartion	NN
cord-006860-a3b8hyyr	1590	17	rate	rate	NN
cord-006860-a3b8hyyr	1590	18	is	be	VBZ
cord-006860-a3b8hyyr	1590	19	still	still	RB
cord-006860-a3b8hyyr	1590	20	high	high	JJ
cord-006860-a3b8hyyr	1590	21	at	at	IN
cord-006860-a3b8hyyr	1590	22	approx	approx	NN
cord-006860-a3b8hyyr	1590	23	.	.	.
cord-006860-a3b8hyyr	1590	24	6	6	CD
cord-006860-a3b8hyyr	1590	25	%	%	NN
cord-006860-a3b8hyyr	1590	26	.	.	.
cord-006860-a3b8hyyr	1591	1	In	in	IN
cord-006860-a3b8hyyr	1591	2	cardiovascular	cardiovascular	JJ
cord-006860-a3b8hyyr	1591	3	surgery	surgery	NN
cord-006860-a3b8hyyr	1591	4	it	-PRON-	PRP
cord-006860-a3b8hyyr	1591	5	is	be	VBZ
cord-006860-a3b8hyyr	1591	6	well	well	RB
cord-006860-a3b8hyyr	1591	7	known	know	VBN
cord-006860-a3b8hyyr	1591	8	that	that	IN
cord-006860-a3b8hyyr	1591	9	various	various	JJ
cord-006860-a3b8hyyr	1591	10	cardioplegic	cardioplegic	NN
cord-006860-a3b8hyyr	1591	11	solutions	solution	NNS
cord-006860-a3b8hyyr	1591	12	are	be	VBP
cord-006860-a3b8hyyr	1591	13	employed	employ	VBN
cord-006860-a3b8hyyr	1591	14	for	for	IN
cord-006860-a3b8hyyr	1591	15	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	1591	16	protection	protection	NN
cord-006860-a3b8hyyr	1591	17	during	during	IN
cord-006860-a3b8hyyr	1591	18	the	the	DT
cord-006860-a3b8hyyr	1591	19	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	1591	20	phase	phase	NN
cord-006860-a3b8hyyr	1591	21	.	.	.
cord-006860-a3b8hyyr	1592	1	In	in	IN
cord-006860-a3b8hyyr	1592	2	order	order	NN
cord-006860-a3b8hyyr	1592	3	to	to	TO
cord-006860-a3b8hyyr	1592	4	evaluate	evaluate	VB
cord-006860-a3b8hyyr	1592	5	the	the	DT
cord-006860-a3b8hyyr	1592	6	possible	possible	JJ
cord-006860-a3b8hyyr	1592	7	influence	influence	NN
cord-006860-a3b8hyyr	1592	8	of	of	IN
cord-006860-a3b8hyyr	1592	9	these	these	DT
cord-006860-a3b8hyyr	1592	10	solutions	solution	NNS
cord-006860-a3b8hyyr	1592	11	we	-PRON-	PRP
cord-006860-a3b8hyyr	1592	12	selected	select	VBD
cord-006860-a3b8hyyr	1592	13	two	two	CD
cord-006860-a3b8hyyr	1592	14	of	of	IN
cord-006860-a3b8hyyr	1592	15	the	the	DT
cord-006860-a3b8hyyr	1592	16	most	most	RBS
cord-006860-a3b8hyyr	1592	17	commonly	commonly	RB
cord-006860-a3b8hyyr	1592	18	used	use	VBN
cord-006860-a3b8hyyr	1592	19	cardioplegic	cardioplegic	JJ
cord-006860-a3b8hyyr	1592	20	solutions	solution	NNS
cord-006860-a3b8hyyr	1592	21	for	for	IN
cord-006860-a3b8hyyr	1592	22	investigation	investigation	NN
cord-006860-a3b8hyyr	1592	23	in	in	IN
cord-006860-a3b8hyyr	1592	24	a	a	DT
cord-006860-a3b8hyyr	1592	25	randomised	randomised	JJ
cord-006860-a3b8hyyr	1592	26	double	double	JJ
cord-006860-a3b8hyyr	1592	27	-	-	HYPH
cord-006860-a3b8hyyr	1592	28	blind	blind	JJ
cord-006860-a3b8hyyr	1592	29	study	study	NN
cord-006860-a3b8hyyr	1592	30	:	:	:
cord-006860-a3b8hyyr	1592	31	HTK	HTK	NNP
cord-006860-a3b8hyyr	1592	32	(	(	-LRB-
cord-006860-a3b8hyyr	1592	33	group	group	NN
cord-006860-a3b8hyyr	1592	34	1	1	CD
cord-006860-a3b8hyyr	1592	35	)	)	-RRB-
cord-006860-a3b8hyyr	1592	36	and	and	CC
cord-006860-a3b8hyyr	1592	37	St.	St.	NNP
cord-006860-a3b8hyyr	1592	38	Thomas	Thomas	NNP
cord-006860-a3b8hyyr	1592	39	(	(	-LRB-
cord-006860-a3b8hyyr	1592	40	group	group	NN
cord-006860-a3b8hyyr	1592	41	2	2	CD
cord-006860-a3b8hyyr	1592	42	)	)	-RRB-
cord-006860-a3b8hyyr	1592	43	.	.	.
cord-006860-a3b8hyyr	1593	1	After	after	IN
cord-006860-a3b8hyyr	1593	2	randomisation	randomisation	NN
cord-006860-a3b8hyyr	1593	3	each	each	DT
cord-006860-a3b8hyyr	1593	4	group	group	NN
cord-006860-a3b8hyyr	1593	5	consisted	consist	VBD
cord-006860-a3b8hyyr	1593	6	of	of	IN
cord-006860-a3b8hyyr	1593	7	20	20	CD
cord-006860-a3b8hyyr	1593	8	patients	patient	NNS
cord-006860-a3b8hyyr	1593	9	who	who	WP
cord-006860-a3b8hyyr	1593	10	had	have	VBD
cord-006860-a3b8hyyr	1593	11	to	to	TO
cord-006860-a3b8hyyr	1593	12	undergo	undergo	VB
cord-006860-a3b8hyyr	1593	13	aortocoronary	aortocoronary	JJ
cord-006860-a3b8hyyr	1593	14	bypass	bypass	NN
cord-006860-a3b8hyyr	1593	15	surgery	surgery	NN
cord-006860-a3b8hyyr	1593	16	.	.	.
cord-006860-a3b8hyyr	1594	1	Aim	Aim	NNP
cord-006860-a3b8hyyr	1594	2	of	of	IN
cord-006860-a3b8hyyr	1594	3	the	the	DT
cord-006860-a3b8hyyr	1594	4	investigation	investigation	NN
cord-006860-a3b8hyyr	1594	5	was	be	VBD
cord-006860-a3b8hyyr	1594	6	to	to	TO
cord-006860-a3b8hyyr	1594	7	establish	establish	VB
cord-006860-a3b8hyyr	1594	8	possible	possible	JJ
cord-006860-a3b8hyyr	1594	9	varying	vary	VBG
cord-006860-a3b8hyyr	1594	10	cellular	cellular	JJ
cord-006860-a3b8hyyr	1594	11	changes	change	NNS
cord-006860-a3b8hyyr	1594	12	during	during	IN
cord-006860-a3b8hyyr	1594	13	the	the	DT
cord-006860-a3b8hyyr	1594	14	reperfusion	reperfusion	NN
cord-006860-a3b8hyyr	1594	15	phase	phase	NN
cord-006860-a3b8hyyr	1594	16	or	or	CC
cord-006860-a3b8hyyr	1594	17	in	in	IN
cord-006860-a3b8hyyr	1594	18	the	the	DT
cord-006860-a3b8hyyr	1594	19	early	early	JJ
cord-006860-a3b8hyyr	1594	20	operative	operative	JJ
cord-006860-a3b8hyyr	1594	21	phase	phase	NN
cord-006860-a3b8hyyr	1594	22	in	in	IN
cord-006860-a3b8hyyr	1594	23	order	order	NN
cord-006860-a3b8hyyr	1594	24	to	to	TO
cord-006860-a3b8hyyr	1594	25	be	be	VB
cord-006860-a3b8hyyr	1594	26	better	well	RBR
cord-006860-a3b8hyyr	1594	27	able	able	JJ
cord-006860-a3b8hyyr	1594	28	to	to	TO
cord-006860-a3b8hyyr	1594	29	apply	apply	VB
cord-006860-a3b8hyyr	1594	30	reinforcing	reinforce	VBG
cord-006860-a3b8hyyr	1594	31	clinical	clinical	JJ
cord-006860-a3b8hyyr	1594	32	measures	measure	NNS
cord-006860-a3b8hyyr	1594	33	.	.	.
cord-006860-a3b8hyyr	1595	1	In	in	IN
cord-006860-a3b8hyyr	1595	2	the	the	DT
cord-006860-a3b8hyyr	1595	3	context	context	NN
cord-006860-a3b8hyyr	1595	4	of	of	IN
cord-006860-a3b8hyyr	1595	5	this	this	DT
cord-006860-a3b8hyyr	1595	6	study	study	NN
cord-006860-a3b8hyyr	1595	7	the	the	DT
cord-006860-a3b8hyyr	1595	8	classical	classical	JJ
cord-006860-a3b8hyyr	1595	9	enzyme	enzyme	NN
cord-006860-a3b8hyyr	1595	10	-	-	HYPH
cord-006860-a3b8hyyr	1595	11	diagnostical	diagnostical	JJ
cord-006860-a3b8hyyr	1595	12	methods	method	NNS
cord-006860-a3b8hyyr	1595	13	CK	CK	NNP
cord-006860-a3b8hyyr	1595	14	,	,	,
cord-006860-a3b8hyyr	1595	15	CK	CK	NNP
cord-006860-a3b8hyyr	1595	16	-	-	HYPH
cord-006860-a3b8hyyr	1595	17	MB	MB	NNP
cord-006860-a3b8hyyr	1595	18	and	and	CC
cord-006860-a3b8hyyr	1595	19	LDH	LDH	NNP
cord-006860-a3b8hyyr	1595	20	as	as	IN
cord-006860-a3b8hyyr	1595	21	most	most	RBS
cord-006860-a3b8hyyr	1595	22	useful	useful	JJ
cord-006860-a3b8hyyr	1595	23	,	,	,
cord-006860-a3b8hyyr	1595	24	however	however	RB
cord-006860-a3b8hyyr	1595	25	not	not	RB
cord-006860-a3b8hyyr	1595	26	as	as	RB
cord-006860-a3b8hyyr	1595	27	convincing	convincing	JJ
cord-006860-a3b8hyyr	1595	28	.	.	.
cord-006860-a3b8hyyr	1596	1	Still	still	RB
cord-006860-a3b8hyyr	1596	2	,	,	,
cord-006860-a3b8hyyr	1596	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	1596	4	have	have	VBP
cord-006860-a3b8hyyr	1596	5	in	in	IN
cord-006860-a3b8hyyr	1596	6	the	the	DT
cord-006860-a3b8hyyr	1596	7	meanwhile	meanwhile	RB
cord-006860-a3b8hyyr	1596	8	been	be	VBN
cord-006860-a3b8hyyr	1596	9	able	able	JJ
cord-006860-a3b8hyyr	1596	10	to	to	TO
cord-006860-a3b8hyyr	1596	11	show	show	VB
cord-006860-a3b8hyyr	1596	12	that	that	IN
cord-006860-a3b8hyyr	1596	13	the	the	DT
cord-006860-a3b8hyyr	1596	14	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	1596	15	muscle	muscle	NN
cord-006860-a3b8hyyr	1596	16	Troponin	Troponin	NNP
cord-006860-a3b8hyyr	1596	17	T	T	NNP
cord-006860-a3b8hyyr	1596	18	proves	prove	VBZ
cord-006860-a3b8hyyr	1596	19	a	a	DT
cord-006860-a3b8hyyr	1596	20	particularly	particularly	RB
cord-006860-a3b8hyyr	1596	21	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	1596	22	parameter	parameter	NN
cord-006860-a3b8hyyr	1596	23	regards	regard	VBZ
cord-006860-a3b8hyyr	1596	24	differentiated	differentiate	VBN
cord-006860-a3b8hyyr	1596	25	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	1596	26	damage	damage	NN
cord-006860-a3b8hyyr	1596	27	to	to	IN
cord-006860-a3b8hyyr	1596	28	the	the	DT
cord-006860-a3b8hyyr	1596	29	myocardium	myocardium	NN
cord-006860-a3b8hyyr	1596	30	.	.	.
cord-006860-a3b8hyyr	1597	1	~his	~his	NNP
cord-006860-a3b8hyyr	1597	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	1597	3	were	be	VBD
cord-006860-a3b8hyyr	1597	4	able	able	JJ
cord-006860-a3b8hyyr	1597	5	to	to	IN
cord-006860-a3b8hyyr	1597	6	confLrm	confLrm	NNS
cord-006860-a3b8hyyr	1597	7	in	in	IN
cord-006860-a3b8hyyr	1597	8	extensive	extensive	JJ
cord-006860-a3b8hyyr	1597	9	preliminary	preliminary	JJ
cord-006860-a3b8hyyr	1597	10	trials	trial	NNS
cord-006860-a3b8hyyr	1597	11	.	.	.
cord-006860-a3b8hyyr	1598	1	Cardiac	Cardiac	NNP
cord-006860-a3b8hyyr	1598	2	Troponin	Troponin	NNP
cord-006860-a3b8hyyr	1598	3	T	T	NNP
cord-006860-a3b8hyyr	1598	4	was	be	VBD
cord-006860-a3b8hyyr	1598	5	registered	register	VBN
cord-006860-a3b8hyyr	1598	6	with	with	IN
cord-006860-a3b8hyyr	1598	7	a	a	DT
cord-006860-a3b8hyyr	1598	8	one	one	CD
cord-006860-a3b8hyyr	1598	9	-	-	HYPH
cord-006860-a3b8hyyr	1598	10	step	step	NN
cord-006860-a3b8hyyr	1598	11	lmmunoassay	lmmunoassay	NN
cord-006860-a3b8hyyr	1598	12	using	use	VBG
cord-006860-a3b8hyyr	1598	13	two	two	CD
cord-006860-a3b8hyyr	1598	14	highly	highly	RB
cord-006860-a3b8hyyr	1598	15	specific	specific	JJ
cord-006860-a3b8hyyr	1598	16	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	1598	17	antibodies	antibody	NNS
cord-006860-a3b8hyyr	1598	18	directly	directly	RB
cord-006860-a3b8hyyr	1598	19	via	via	IN
cord-006860-a3b8hyyr	1598	20	two	two	CD
cord-006860-a3b8hyyr	1598	21	different	different	JJ
cord-006860-a3b8hyyr	1598	22	epitopes	epitope	NNS
cord-006860-a3b8hyyr	1598	23	of	of	IN
cord-006860-a3b8hyyr	1598	24	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	1598	25	Troponin	Troponin	NNP
cord-006860-a3b8hyyr	1598	26	T.	T.	NNP
cord-006860-a3b8hyyr	1598	27	Simultaneously	simultaneously	RB
cord-006860-a3b8hyyr	1598	28	the	the	DT
cord-006860-a3b8hyyr	1598	29	corresponding	corresponding	JJ
cord-006860-a3b8hyyr	1598	30	pre	pre	JJ
cord-006860-a3b8hyyr	1598	31	-	-	JJ
cord-006860-a3b8hyyr	1598	32	and	and	CC
cord-006860-a3b8hyyr	1598	33	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	1598	34	ECG	ECG	NNP
cord-006860-a3b8hyyr	1598	35	was	be	VBD
cord-006860-a3b8hyyr	1598	36	registered	register	VBN
cord-006860-a3b8hyyr	1598	37	.	.	.
cord-006860-a3b8hyyr	1599	1	Further	further	RB
cord-006860-a3b8hyyr	1599	2	,	,	,
cord-006860-a3b8hyyr	1599	3	within	within	IN
cord-006860-a3b8hyyr	1599	4	this	this	DT
cord-006860-a3b8hyyr	1599	5	context	context	NN
cord-006860-a3b8hyyr	1599	6	we	-PRON-	PRP
cord-006860-a3b8hyyr	1599	7	investigated	investigate	VBD
cord-006860-a3b8hyyr	1599	8	parameters	parameter	NNS
cord-006860-a3b8hyyr	1599	9	that	that	WDT
cord-006860-a3b8hyyr	1599	10	indicate	indicate	VBP
cord-006860-a3b8hyyr	1599	11	cellular	cellular	JJ
cord-006860-a3b8hyyr	1599	12	damage	damage	NN
cord-006860-a3b8hyyr	1599	13	,	,	,
cord-006860-a3b8hyyr	1599	14	such	such	JJ
cord-006860-a3b8hyyr	1599	15	as	as	IN
cord-006860-a3b8hyyr	1599	16	platelet	platelet	NN
cord-006860-a3b8hyyr	1599	17	factor	factor	NN
cord-006860-a3b8hyyr	1599	18	4	4	CD
cord-006860-a3b8hyyr	1599	19	(	(	-LRB-
cord-006860-a3b8hyyr	1599	20	PF4	PF4	NNP
cord-006860-a3b8hyyr	1599	21	)	)	-RRB-
cord-006860-a3b8hyyr	1599	22	,	,	,
cord-006860-a3b8hyyr	1599	23	t	t	NNP
cord-006860-a3b8hyyr	1599	24	-	-	HYPH
cord-006860-a3b8hyyr	1599	25	PA	PA	NNP
cord-006860-a3b8hyyr	1599	26	,	,	,
cord-006860-a3b8hyyr	1599	27	Interleukin-6	Interleukin-6	NNP
cord-006860-a3b8hyyr	1599	28	and	and	CC
cord-006860-a3b8hyyr	1599	29	PMN	PMN	NNP
cord-006860-a3b8hyyr	1599	30	-	-	HYPH
cord-006860-a3b8hyyr	1599	31	elastase	elastase	NN
cord-006860-a3b8hyyr	1599	32	.	.	.
cord-006860-a3b8hyyr	1600	1	In	in	IN
cord-006860-a3b8hyyr	1600	2	the	the	DT
cord-006860-a3b8hyyr	1600	3	reperfusion	reperfusion	NN
cord-006860-a3b8hyyr	1600	4	phase	phase	NN
cord-006860-a3b8hyyr	1600	5	in	in	IN
cord-006860-a3b8hyyr	1600	6	group	group	NN
cord-006860-a3b8hyyr	1600	7	2	2	CD
cord-006860-a3b8hyyr	1600	8	there	there	EX
cord-006860-a3b8hyyr	1600	9	is	be	VBZ
cord-006860-a3b8hyyr	1600	10	a	a	DT
cord-006860-a3b8hyyr	1600	11	significant	significant	JJ
cord-006860-a3b8hyyr	1600	12	rise	rise	NN
cord-006860-a3b8hyyr	1600	13	in	in	IN
cord-006860-a3b8hyyr	1600	14	Tmponin	Tmponin	NNP
cord-006860-a3b8hyyr	1600	15	T	T	NNP
cord-006860-a3b8hyyr	1600	16	while	while	NN
cord-006860-a3b8hyyr	1600	17	in	in	IN
cord-006860-a3b8hyyr	1600	18	group	group	NN
cord-006860-a3b8hyyr	1600	19	1	1	CD
cord-006860-a3b8hyyr	1600	20	these	these	DT
cord-006860-a3b8hyyr	1600	21	values	value	NNS
cord-006860-a3b8hyyr	1600	22	remain	remain	VBP
cord-006860-a3b8hyyr	1600	23	practically	practically	RB
cord-006860-a3b8hyyr	1600	24	unchanged	unchanged	JJ
cord-006860-a3b8hyyr	1600	25	up	up	RP
cord-006860-a3b8hyyr	1600	26	to	to	IN
cord-006860-a3b8hyyr	1600	27	the	the	DT
cord-006860-a3b8hyyr	1600	28	1st	1st	NN
cord-006860-a3b8hyyr	1600	29	.	.	.
cord-006860-a3b8hyyr	1601	1	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	1601	2	day	day	NN
cord-006860-a3b8hyyr	1601	3	.	.	.
cord-006860-a3b8hyyr	1602	1	Of	of	IN
cord-006860-a3b8hyyr	1602	2	special	special	JJ
cord-006860-a3b8hyyr	1602	3	importance	importance	NN
cord-006860-a3b8hyyr	1602	4	is	be	VBZ
cord-006860-a3b8hyyr	1602	5	interleucin	interleucin	NNS
cord-006860-a3b8hyyr	1602	6	6	6	CD
cord-006860-a3b8hyyr	1602	7	since	since	IN
cord-006860-a3b8hyyr	1602	8	according	accord	VBG
cord-006860-a3b8hyyr	1602	9	to	to	IN
cord-006860-a3b8hyyr	1602	10	most	most	JJS
cord-006860-a3b8hyyr	1602	11	recent	recent	JJ
cord-006860-a3b8hyyr	1602	12	studies	study	NNS
cord-006860-a3b8hyyr	1602	13	the	the	DT
cord-006860-a3b8hyyr	1602	14	release	release	NN
cord-006860-a3b8hyyr	1602	15	of	of	IN
cord-006860-a3b8hyyr	1602	16	this	this	DT
cord-006860-a3b8hyyr	1602	17	substance	substance	NN
cord-006860-a3b8hyyr	1602	18	leads	lead	VBZ
cord-006860-a3b8hyyr	1602	19	to	to	IN
cord-006860-a3b8hyyr	1602	20	platelet	platelet	NN
cord-006860-a3b8hyyr	1602	21	activation	activation	NN
cord-006860-a3b8hyyr	1602	22	via	via	IN
cord-006860-a3b8hyyr	1602	23	the	the	DT
cord-006860-a3b8hyyr	1602	24	arachidonic	arachidonic	JJ
cord-006860-a3b8hyyr	1602	25	acid	acid	NN
cord-006860-a3b8hyyr	1602	26	metabolism	metabolism	NN
cord-006860-a3b8hyyr	1602	27	.	.	.
cord-006860-a3b8hyyr	1603	1	This	this	DT
cord-006860-a3b8hyyr	1603	2	pathway	pathway	NN
cord-006860-a3b8hyyr	1603	3	must	must	MD
cord-006860-a3b8hyyr	1603	4	,	,	,
cord-006860-a3b8hyyr	1603	5	further	further	RB
cord-006860-a3b8hyyr	1603	6	,	,	,
cord-006860-a3b8hyyr	1603	7	be	be	VB
cord-006860-a3b8hyyr	1603	8	regarded	regard	VBN
cord-006860-a3b8hyyr	1603	9	within	within	IN
cord-006860-a3b8hyyr	1603	10	the	the	DT
cord-006860-a3b8hyyr	1603	11	context	context	NN
cord-006860-a3b8hyyr	1603	12	of	of	IN
cord-006860-a3b8hyyr	1603	13	free	free	JJ
cord-006860-a3b8hyyr	1603	14	radical	radical	JJ
cord-006860-a3b8hyyr	1603	15	formation	formation	NN
cord-006860-a3b8hyyr	1603	16	.	.	.
cord-006860-a3b8hyyr	1604	1	On	on	IN
cord-006860-a3b8hyyr	1604	2	the	the	DT
cord-006860-a3b8hyyr	1604	3	1st	1st	NN
cord-006860-a3b8hyyr	1604	4	.	.	.
cord-006860-a3b8hyyr	1605	1	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	1605	2	day	day	NN
cord-006860-a3b8hyyr	1605	3	the	the	DT
cord-006860-a3b8hyyr	1605	4	11	11	CD
cord-006860-a3b8hyyr	1605	5	6	6	CD
cord-006860-a3b8hyyr	1605	6	values	value	NNS
cord-006860-a3b8hyyr	1605	7	in	in	IN
cord-006860-a3b8hyyr	1605	8	group	group	NN
cord-006860-a3b8hyyr	1605	9	2	2	CD
cord-006860-a3b8hyyr	1605	10	are	be	VBP
cord-006860-a3b8hyyr	1605	11	significantly	significantly	RB
cord-006860-a3b8hyyr	1605	12	higher	high	JJR
cord-006860-a3b8hyyr	1605	13	.	.	.
cord-006860-a3b8hyyr	1606	1	The	the	DT
cord-006860-a3b8hyyr	1606	2	effects	effect	NNS
cord-006860-a3b8hyyr	1606	3	of	of	IN
cord-006860-a3b8hyyr	1606	4	membrane	membrane	NN
cord-006860-a3b8hyyr	1606	5	damage	damage	NN
cord-006860-a3b8hyyr	1606	6	is	be	VBZ
cord-006860-a3b8hyyr	1606	7	also	also	RB
cord-006860-a3b8hyyr	1606	8	observed	observe	VBN
cord-006860-a3b8hyyr	1606	9	via	via	IN
cord-006860-a3b8hyyr	1606	10	PF4	pf4	NN
cord-006860-a3b8hyyr	1606	11	and	and	CC
cord-006860-a3b8hyyr	1606	12	the	the	DT
cord-006860-a3b8hyyr	1606	13	PMN	pmn	NN
cord-006860-a3b8hyyr	1606	14	-	-	HYPH
cord-006860-a3b8hyyr	1606	15	elastase	elastase	NN
cord-006860-a3b8hyyr	1606	16	to	to	TO
cord-006860-a3b8hyyr	1606	17	be	be	VB
cord-006860-a3b8hyyr	1606	18	different	different	JJ
cord-006860-a3b8hyyr	1606	19	in	in	IN
cord-006860-a3b8hyyr	1606	20	both	both	DT
cord-006860-a3b8hyyr	1606	21	groups	group	NNS
cord-006860-a3b8hyyr	1606	22	.	.	.
cord-006860-a3b8hyyr	1607	1	On	on	IN
cord-006860-a3b8hyyr	1607	2	the	the	DT
cord-006860-a3b8hyyr	1607	3	basis	basis	NN
cord-006860-a3b8hyyr	1607	4	of	of	IN
cord-006860-a3b8hyyr	1607	5	this	this	DT
cord-006860-a3b8hyyr	1607	6	study	study	NN
cord-006860-a3b8hyyr	1607	7	we	-PRON-	PRP
cord-006860-a3b8hyyr	1607	8	arrive	arrive	VBP
cord-006860-a3b8hyyr	1607	9	at	at	IN
cord-006860-a3b8hyyr	1607	10	the	the	DT
cord-006860-a3b8hyyr	1607	11	conclusion	conclusion	NN
cord-006860-a3b8hyyr	1607	12	that	that	IN
cord-006860-a3b8hyyr	1607	13	the	the	DT
cord-006860-a3b8hyyr	1607	14	HTKcardioplegia	HTKcardioplegia	NNP
cord-006860-a3b8hyyr	1607	15	is	be	VBZ
cord-006860-a3b8hyyr	1607	16	essentially	essentially	RB
cord-006860-a3b8hyyr	1607	17	less	less	RBR
cord-006860-a3b8hyyr	1607	18	damaging	damaging	JJ
cord-006860-a3b8hyyr	1607	19	than	than	IN
cord-006860-a3b8hyyr	1607	20	that	that	DT
cord-006860-a3b8hyyr	1607	21	of	of	IN
cord-006860-a3b8hyyr	1607	22	the	the	DT
cord-006860-a3b8hyyr	1607	23	St.	St.	NNP
cord-006860-a3b8hyyr	1607	24	Thomas	Thomas	NNP
cord-006860-a3b8hyyr	1607	25	solution	solution	NN
cord-006860-a3b8hyyr	1607	26	.	.	.
cord-006860-a3b8hyyr	1608	1	(	(	-LRB-
cord-006860-a3b8hyyr	1608	2	2	2	LS
cord-006860-a3b8hyyr	1608	3	)	)	-RRB-
cord-006860-a3b8hyyr	1608	4	R.	R.	NNP
cord-006860-a3b8hyyr	1608	5	Hetzer	Hetzer	NNP
cord-006860-a3b8hyyr	1608	6	(	(	-LRB-
cord-006860-a3b8hyyr	1608	7	2	2	CD
cord-006860-a3b8hyyr	1608	8	)	)	-RRB-
cord-006860-a3b8hyyr	1608	9	(	(	-LRB-
cord-006860-a3b8hyyr	1608	10	1	1	LS
cord-006860-a3b8hyyr	1608	11	)	)	-RRB-
cord-006860-a3b8hyyr	1608	12	Department	Department	NNP
cord-006860-a3b8hyyr	1608	13	of	of	IN
cord-006860-a3b8hyyr	1608	14	Hematology	Hematology	NNP
cord-006860-a3b8hyyr	1608	15	and	and	CC
cord-006860-a3b8hyyr	1608	16	Oncology	Oncology	NNP
cord-006860-a3b8hyyr	1608	17	,	,	,
cord-006860-a3b8hyyr	1608	18	Vimhow	Vimhow	NNP
cord-006860-a3b8hyyr	1608	19	Klinikum	Klinikum	NNP
cord-006860-a3b8hyyr	1608	20	,	,	,
cord-006860-a3b8hyyr	1608	21	Humboldt	Humboldt	NNP
cord-006860-a3b8hyyr	1608	22	University	University	NNP
cord-006860-a3b8hyyr	1608	23	,	,	,
cord-006860-a3b8hyyr	1608	24	Berlin	Berlin	NNP
cord-006860-a3b8hyyr	1608	25	,	,	,
cord-006860-a3b8hyyr	1608	26	Germany	Germany	NNP
cord-006860-a3b8hyyr	1608	27	(	(	-LRB-
cord-006860-a3b8hyyr	1609	1	2	2	LS
cord-006860-a3b8hyyr	1609	2	)	)	-RRB-
cord-006860-a3b8hyyr	1609	3	We	-PRON-	PRP
cord-006860-a3b8hyyr	1609	4	investigated	investigate	VBD
cord-006860-a3b8hyyr	1609	5	the	the	DT
cord-006860-a3b8hyyr	1609	6	influence	influence	NN
cord-006860-a3b8hyyr	1609	7	of	of	IN
cord-006860-a3b8hyyr	1609	8	two	two	CD
cord-006860-a3b8hyyr	1609	9	different	different	JJ
cord-006860-a3b8hyyr	1609	10	VAD	VAD	NNP
cord-006860-a3b8hyyr	1609	11	systems	system	NNS
cord-006860-a3b8hyyr	1609	12	on	on	IN
cord-006860-a3b8hyyr	1609	13	these	these	DT
cord-006860-a3b8hyyr	1609	14	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	1609	15	changes	change	NNS
cord-006860-a3b8hyyr	1609	16	.	.	.
cord-006860-a3b8hyyr	1610	1	VADs	vad	NNS
cord-006860-a3b8hyyr	1610	2	were	be	VBD
cord-006860-a3b8hyyr	1610	3	implanted	implant	VBN
cord-006860-a3b8hyyr	1610	4	in	in	IN
cord-006860-a3b8hyyr	1610	5	18	18	CD
cord-006860-a3b8hyyr	1610	6	patients	patient	NNS
cord-006860-a3b8hyyr	1610	7	[	[	-LRB-
cord-006860-a3b8hyyr	1610	8	11	11	CD
cord-006860-a3b8hyyr	1610	9	bi	bi	JJ
cord-006860-a3b8hyyr	1610	10	-	-	HYPH
cord-006860-a3b8hyyr	1610	11	VAD	VAD	NNP
cord-006860-a3b8hyyr	1610	12	(	(	-LRB-
cord-006860-a3b8hyyr	1610	13	Berlin	Berlin	NNP
cord-006860-a3b8hyyr	1610	14	Heart	Heart	NNP
cord-006860-a3b8hyyr	1610	15	)	)	-RRB-
cord-006860-a3b8hyyr	1610	16	,	,	,
cord-006860-a3b8hyyr	1610	17	7	7	CD
cord-006860-a3b8hyyr	1610	18	left	leave	VBD
cord-006860-a3b8hyyr	1610	19	VAD	VAD	NNP
cord-006860-a3b8hyyr	1610	20	(	(	-LRB-
cord-006860-a3b8hyyr	1610	21	Novacor	Novacor	NNP
cord-006860-a3b8hyyr	1610	22	N	N	NNP
cord-006860-a3b8hyyr	1610	23	100	100	CD
cord-006860-a3b8hyyr	1610	24	)	)	-RRB-
cord-006860-a3b8hyyr	1610	25	]	]	-RRB-
cord-006860-a3b8hyyr	1610	26	with	with	IN
cord-006860-a3b8hyyr	1610	27	end	end	JJ
cord-006860-a3b8hyyr	1610	28	-	-	HYPH
cord-006860-a3b8hyyr	1610	29	stage	stage	NN
cord-006860-a3b8hyyr	1610	30	heart	heart	NN
cord-006860-a3b8hyyr	1610	31	disease	disease	NN
cord-006860-a3b8hyyr	1610	32	who	who	WP
cord-006860-a3b8hyyr	1610	33	were	be	VBD
cord-006860-a3b8hyyr	1610	34	awaiting	await	VBG
cord-006860-a3b8hyyr	1610	35	heart	heart	NN
cord-006860-a3b8hyyr	1610	36	transplantation	transplantation	NN
cord-006860-a3b8hyyr	1610	37	.	.	.
cord-006860-a3b8hyyr	1611	1	The	the	DT
cord-006860-a3b8hyyr	1611	2	following	follow	VBG
cord-006860-a3b8hyyr	1611	3	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	1611	4	parameters	parameter	NNS
cord-006860-a3b8hyyr	1611	5	were	be	VBD
cord-006860-a3b8hyyr	1611	6	measured	measure	VBN
cord-006860-a3b8hyyr	1611	7	during	during	IN
cord-006860-a3b8hyyr	1611	8	the	the	DT
cord-006860-a3b8hyyr	1611	9	first	first	JJ
cord-006860-a3b8hyyr	1611	10	51	51	CD
cord-006860-a3b8hyyr	1611	11	days	day	NNS
cord-006860-a3b8hyyr	1611	12	of	of	IN
cord-006860-a3b8hyyr	1611	13	bddging	bddging	NN
cord-006860-a3b8hyyr	1611	14	or	or	CC
cord-006860-a3b8hyyr	1611	15	until	until	IN
cord-006860-a3b8hyyr	1611	16	heart	heart	NN
cord-006860-a3b8hyyr	1611	17	transplantation	transplantation	NN
cord-006860-a3b8hyyr	1611	18	:	:	:
cord-006860-a3b8hyyr	1611	19	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1611	20	-	-	HYPH
cord-006860-a3b8hyyr	1611	21	antithrembin	antithrembin	NNP
cord-006860-a3b8hyyr	1611	22	III	III	NNP
cord-006860-a3b8hyyr	1611	23	(	(	-LRB-
cord-006860-a3b8hyyr	1611	24	TAT	TAT	NNP
cord-006860-a3b8hyyr	1611	25	)	)	-RRB-
cord-006860-a3b8hyyr	1611	26	complexes	complex	NNS
cord-006860-a3b8hyyr	1611	27	,	,	,
cord-006860-a3b8hyyr	1611	28	prekallikrein	prekallikrein	NNP
cord-006860-a3b8hyyr	1611	29	,	,	,
cord-006860-a3b8hyyr	1611	30	factor	factor	NN
cord-006860-a3b8hyyr	1611	31	(	(	-LRB-
cord-006860-a3b8hyyr	1611	32	F	F	NNP
cord-006860-a3b8hyyr	1611	33	)	)	-RRB-
cord-006860-a3b8hyyr	1611	34	Xll	Xll	NNP
cord-006860-a3b8hyyr	1611	35	,	,	,
cord-006860-a3b8hyyr	1611	36	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	1611	37	,	,	,
cord-006860-a3b8hyyr	1611	38	or2	or2	NNP
cord-006860-a3b8hyyr	1611	39	-antiplasmin	-antiplasmin	SYM
cord-006860-a3b8hyyr	1611	40	,	,	,
cord-006860-a3b8hyyr	1611	41	and	and	CC
cord-006860-a3b8hyyr	1611	42	I?,thremboglobulin	i?,thremboglobulin	NN
cord-006860-a3b8hyyr	1611	43	.	.	.
cord-006860-a3b8hyyr	1612	1	RESULTS	result	NNS
cord-006860-a3b8hyyr	1612	2	:	:	:
cord-006860-a3b8hyyr	1613	1	During	during	IN
cord-006860-a3b8hyyr	1613	2	the	the	DT
cord-006860-a3b8hyyr	1613	3	first	first	JJ
cord-006860-a3b8hyyr	1613	4	week	week	NN
cord-006860-a3b8hyyr	1613	5	of	of	IN
cord-006860-a3b8hyyr	1613	6	bridging	bridging	NN
cord-006860-a3b8hyyr	1613	7	,	,	,
cord-006860-a3b8hyyr	1613	8	significantly	significantly	RB
cord-006860-a3b8hyyr	1613	9	higher	high	JJR
cord-006860-a3b8hyyr	1613	10	TAT	tat	NN
cord-006860-a3b8hyyr	1613	11	levels	level	NNS
cord-006860-a3b8hyyr	1613	12	were	be	VBD
cord-006860-a3b8hyyr	1613	13	observed	observe	VBN
cord-006860-a3b8hyyr	1613	14	in	in	IN
cord-006860-a3b8hyyr	1613	15	Novacor	Novacor	NNP
cord-006860-a3b8hyyr	1613	16	patients	patient	NNS
cord-006860-a3b8hyyr	1613	17	compared	compare	VBN
cord-006860-a3b8hyyr	1613	18	to	to	IN
cord-006860-a3b8hyyr	1613	19	Berlin	Berlin	NNP
cord-006860-a3b8hyyr	1613	20	Heart	Heart	NNP
cord-006860-a3b8hyyr	1613	21	patients	patient	NNS
cord-006860-a3b8hyyr	1613	22	.	.	.
cord-006860-a3b8hyyr	1614	1	Prekallikrein	prekallikrein	NN
cord-006860-a3b8hyyr	1614	2	activity	activity	NN
cord-006860-a3b8hyyr	1614	3	levels	level	NNS
cord-006860-a3b8hyyr	1614	4	were	be	VBD
cord-006860-a3b8hyyr	1614	5	significantly	significantly	RB
cord-006860-a3b8hyyr	1614	6	lower	low	JJR
cord-006860-a3b8hyyr	1614	7	in	in	IN
cord-006860-a3b8hyyr	1614	8	the	the	DT
cord-006860-a3b8hyyr	1614	9	Berlin	Berlin	NNP
cord-006860-a3b8hyyr	1614	10	Heart	Heart	NNP
cord-006860-a3b8hyyr	1614	11	patients	patient	NNS
cord-006860-a3b8hyyr	1614	12	in	in	IN
cord-006860-a3b8hyyr	1614	13	the	the	DT
cord-006860-a3b8hyyr	1614	14	early	early	JJ
cord-006860-a3b8hyyr	1614	15	bridging	bridging	NN
cord-006860-a3b8hyyr	1614	16	period	period	NN
cord-006860-a3b8hyyr	1614	17	.	.	.
cord-006860-a3b8hyyr	1615	1	All	all	DT
cord-006860-a3b8hyyr	1615	2	other	other	JJ
cord-006860-a3b8hyyr	1615	3	parameters	parameter	NNS
cord-006860-a3b8hyyr	1615	4	were	be	VBD
cord-006860-a3b8hyyr	1615	5	comparable	comparable	JJ
cord-006860-a3b8hyyr	1615	6	in	in	IN
cord-006860-a3b8hyyr	1615	7	both	both	DT
cord-006860-a3b8hyyr	1615	8	groups	group	NNS
cord-006860-a3b8hyyr	1615	9	throughout	throughout	IN
cord-006860-a3b8hyyr	1615	10	the	the	DT
cord-006860-a3b8hyyr	1615	11	entire	entire	JJ
cord-006860-a3b8hyyr	1615	12	observation	observation	NN
cord-006860-a3b8hyyr	1615	13	period	period	NN
cord-006860-a3b8hyyr	1615	14	.	.	.
cord-006860-a3b8hyyr	1616	1	Differences	difference	NNS
cord-006860-a3b8hyyr	1616	2	in	in	IN
cord-006860-a3b8hyyr	1616	3	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	1616	4	parameters	parameter	NNS
cord-006860-a3b8hyyr	1616	5	became	become	VBD
cord-006860-a3b8hyyr	1616	6	apparent	apparent	JJ
cord-006860-a3b8hyyr	1616	7	only	only	RB
cord-006860-a3b8hyyr	1616	8	in	in	IN
cord-006860-a3b8hyyr	1616	9	the	the	DT
cord-006860-a3b8hyyr	1616	10	early	early	JJ
cord-006860-a3b8hyyr	1616	11	bridging	bridging	NN
cord-006860-a3b8hyyr	1616	12	period	period	NN
cord-006860-a3b8hyyr	1616	13	with	with	IN
cord-006860-a3b8hyyr	1616	14	more	more	RBR
cord-006860-a3b8hyyr	1616	15	enhanced	enhance	VBN
cord-006860-a3b8hyyr	1616	16	pmthrombin	pmthrombin	NN
cord-006860-a3b8hyyr	1616	17	activation	activation	NN
cord-006860-a3b8hyyr	1616	18	in	in	IN
cord-006860-a3b8hyyr	1616	19	the	the	DT
cord-006860-a3b8hyyr	1616	20	Novacor	Novacor	NNP
cord-006860-a3b8hyyr	1616	21	group	group	NN
cord-006860-a3b8hyyr	1616	22	and	and	CC
cord-006860-a3b8hyyr	1616	23	more	more	JJR
cord-006860-a3b8hyyr	1616	24	prominent	prominent	JJ
cord-006860-a3b8hyyr	1616	25	contact	contact	NN
cord-006860-a3b8hyyr	1616	26	activation	activation	NN
cord-006860-a3b8hyyr	1616	27	in	in	IN
cord-006860-a3b8hyyr	1616	28	the	the	DT
cord-006860-a3b8hyyr	1616	29	Berlin	Berlin	NNP
cord-006860-a3b8hyyr	1616	30	heart	heart	NN
cord-006860-a3b8hyyr	1616	31	group	group	NN
cord-006860-a3b8hyyr	1616	32	.	.	.
cord-006860-a3b8hyyr	1617	1	Avoidance	avoidance	NN
cord-006860-a3b8hyyr	1617	2	of	of	IN
cord-006860-a3b8hyyr	1617	3	the	the	DT
cord-006860-a3b8hyyr	1617	4	transmission	transmission	NN
cord-006860-a3b8hyyr	1617	5	of	of	IN
cord-006860-a3b8hyyr	1617	6	viral	viral	JJ
cord-006860-a3b8hyyr	1617	7	infections	infection	NNS
cord-006860-a3b8hyyr	1617	8	and	and	CC
cord-006860-a3b8hyyr	1617	9	saving	save	VBG
cord-006860-a3b8hyyr	1617	10	in	in	IN
cord-006860-a3b8hyyr	1617	11	the	the	DT
cord-006860-a3b8hyyr	1617	12	use	use	NN
cord-006860-a3b8hyyr	1617	13	of	of	IN
cord-006860-a3b8hyyr	1617	14	blood	blood	NN
cord-006860-a3b8hyyr	1617	15	products	product	NNS
cord-006860-a3b8hyyr	1617	16	encouraged	encourage	VBD
cord-006860-a3b8hyyr	1617	17	the	the	DT
cord-006860-a3b8hyyr	1617	18	use	use	NN
cord-006860-a3b8hyyr	1617	19	of	of	IN
cord-006860-a3b8hyyr	1617	20	apparatwe	apparatwe	JJ
cord-006860-a3b8hyyr	1617	21	intraoperative	intraoperative	JJ
cord-006860-a3b8hyyr	1617	22	autetransfusion	autetransfusion	NN
cord-006860-a3b8hyyr	1617	23	techniques	technique	NNS
cord-006860-a3b8hyyr	1617	24	.	.	.
cord-006860-a3b8hyyr	1618	1	Patients	patient	NNS
cord-006860-a3b8hyyr	1618	2	and	and	CC
cord-006860-a3b8hyyr	1618	3	methods	method	NNS
cord-006860-a3b8hyyr	1618	4	:	:	:
cord-006860-a3b8hyyr	1619	1	ARer	ARer	NNP
cord-006860-a3b8hyyr	1619	2	randomization	randomization	NN
cord-006860-a3b8hyyr	1619	3	apparative	apparative	NNP
cord-006860-a3b8hyyr	1619	4	intraoperative	intraoperative	JJ
cord-006860-a3b8hyyr	1619	5	autotransfusion	autotransfusion	NN
cord-006860-a3b8hyyr	1619	6	was	be	VBD
cord-006860-a3b8hyyr	1619	7	performed	perform	VBN
cord-006860-a3b8hyyr	1619	8	in	in	IN
cord-006860-a3b8hyyr	1619	9	5x7	5x7	CD
cord-006860-a3b8hyyr	1619	10	patients	patient	NNS
cord-006860-a3b8hyyr	1619	11	during	during	IN
cord-006860-a3b8hyyr	1619	12	elective	elective	JJ
cord-006860-a3b8hyyr	1619	13	hip	hip	NN
cord-006860-a3b8hyyr	1619	14	surgery	surgery	NN
cord-006860-a3b8hyyr	1619	15	using	use	VBG
cord-006860-a3b8hyyr	1619	16	I	I	NNP
cord-006860-a3b8hyyr	1619	17	-	-	HYPH
cord-006860-a3b8hyyr	1619	18	Iaemonetics	Iaemonetics	NNP
cord-006860-a3b8hyyr	1619	19	Cell	Cell	NNP
cord-006860-a3b8hyyr	1619	20	saver	saver	NN
cord-006860-a3b8hyyr	1619	21	Ill	Ill	NNP
cord-006860-a3b8hyyr	1619	22	,	,	,
cord-006860-a3b8hyyr	1619	23	Haemonetics	Haemonetics	NNP
cord-006860-a3b8hyyr	1619	24	Cell	Cell	NNP
cord-006860-a3b8hyyr	1619	25	saver	saver	NN
cord-006860-a3b8hyyr	1619	26	V	v	NN
cord-006860-a3b8hyyr	1619	27	,	,	,
cord-006860-a3b8hyyr	1619	28	Electromedics	Electromedics	NNP
cord-006860-a3b8hyyr	1619	29	Elmd	Elmd	NNP
cord-006860-a3b8hyyr	1619	30	,	,	,
cord-006860-a3b8hyyr	1619	31	HaemoLite	HaemoLite	NNP
cord-006860-a3b8hyyr	1619	32	3	3	CD
cord-006860-a3b8hyyr	1619	33	and	and	CC
cord-006860-a3b8hyyr	1619	34	Fresenius	Fresenius	NNP
cord-006860-a3b8hyyr	1619	35	Continuous	Continuous	NNP
cord-006860-a3b8hyyr	1619	36	AutoTransfnsion	AutoTransfnsion	NNP
cord-006860-a3b8hyyr	1619	37	System	system	NN
cord-006860-a3b8hyyr	1619	38	(	(	-LRB-
cord-006860-a3b8hyyr	1619	39	CATS	CATS	NNP
cord-006860-a3b8hyyr	1619	40	)	)	-RRB-
cord-006860-a3b8hyyr	1619	41	.	.	.
cord-006860-a3b8hyyr	1620	1	At	at	IN
cord-006860-a3b8hyyr	1620	2	defined	define	VBN
cord-006860-a3b8hyyr	1620	3	tmaes	tmaes	NN
cord-006860-a3b8hyyr	1620	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	1620	5	detenmned	detenmne	VBD
cord-006860-a3b8hyyr	1620	6	a	a	DT
cord-006860-a3b8hyyr	1620	7	lab	lab	NN
cord-006860-a3b8hyyr	1620	8	panel	panel	NN
cord-006860-a3b8hyyr	1620	9	(	(	-LRB-
cord-006860-a3b8hyyr	1620	10	clinical	clinical	JJ
cord-006860-a3b8hyyr	1620	11	chemistry	chemistry	NN
cord-006860-a3b8hyyr	1620	12	,	,	,
cord-006860-a3b8hyyr	1620	13	lipids	lipid	NNS
cord-006860-a3b8hyyr	1620	14	,	,	,
cord-006860-a3b8hyyr	1620	15	proteolytic	proteolytic	JJ
cord-006860-a3b8hyyr	1620	16	capacity	capacity	NN
cord-006860-a3b8hyyr	1620	17	,	,	,
cord-006860-a3b8hyyr	1620	18	hemolysis	hemolysis	NN
cord-006860-a3b8hyyr	1620	19	,	,	,
cord-006860-a3b8hyyr	1620	20	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1620	21	panel	panel	NN
cord-006860-a3b8hyyr	1620	22	)	)	-RRB-
cord-006860-a3b8hyyr	1620	23	at	at	IN
cord-006860-a3b8hyyr	1620	24	9	9	CD
cord-006860-a3b8hyyr	1620	25	determination	determination	NN
cord-006860-a3b8hyyr	1620	26	points	point	NNS
cord-006860-a3b8hyyr	1620	27	in	in	IN
cord-006860-a3b8hyyr	1620	28	the	the	DT
cord-006860-a3b8hyyr	1620	29	reservoir	reservoir	NN
cord-006860-a3b8hyyr	1620	30	,	,	,
cord-006860-a3b8hyyr	1620	31	the	the	DT
cord-006860-a3b8hyyr	1620	32	retransfused	retransfused	JJ
cord-006860-a3b8hyyr	1620	33	blood	blood	NN
cord-006860-a3b8hyyr	1620	34	and	and	CC
cord-006860-a3b8hyyr	1620	35	in	in	IN
cord-006860-a3b8hyyr	1620	36	the	the	DT
cord-006860-a3b8hyyr	1620	37	patient	patient	NN
cord-006860-a3b8hyyr	1620	38	.	.	.
cord-006860-a3b8hyyr	1621	1	Results	result	NNS
cord-006860-a3b8hyyr	1621	2	:	:	:
cord-006860-a3b8hyyr	1622	1	No	no	DT
cord-006860-a3b8hyyr	1622	2	significant	significant	JJ
cord-006860-a3b8hyyr	1622	3	differences	difference	NNS
cord-006860-a3b8hyyr	1622	4	concerning	concern	VBG
cord-006860-a3b8hyyr	1622	5	proteolytic	proteolytic	JJ
cord-006860-a3b8hyyr	1622	6	capacity	capacity	NN
cord-006860-a3b8hyyr	1622	7	,	,	,
cord-006860-a3b8hyyr	1622	8	prothrombin	prothrombin	JJ
cord-006860-a3b8hyyr	1622	9	time	time	NN
cord-006860-a3b8hyyr	1622	10	,	,	,
cord-006860-a3b8hyyr	1622	11	platelets	platelet	NNS
cord-006860-a3b8hyyr	1622	12	,	,	,
cord-006860-a3b8hyyr	1622	13	lipids	lipid	NNS
cord-006860-a3b8hyyr	1622	14	,	,	,
cord-006860-a3b8hyyr	1622	15	electrolytes	electrolyte	NNS
cord-006860-a3b8hyyr	1622	16	.	.	.
cord-006860-a3b8hyyr	1623	1	Increased	increase	VBN
cord-006860-a3b8hyyr	1623	2	hemolysis	hemolysis	NN
cord-006860-a3b8hyyr	1623	3	(	(	-LRB-
cord-006860-a3b8hyyr	1623	4	p<0.01	p<0.01	NNP
cord-006860-a3b8hyyr	1623	5	)	)	-RRB-
cord-006860-a3b8hyyr	1623	6	in	in	IN
cord-006860-a3b8hyyr	1623	7	the	the	DT
cord-006860-a3b8hyyr	1623	8	HCS	HCS	NNP
cord-006860-a3b8hyyr	1623	9	III	III	NNP
cord-006860-a3b8hyyr	1623	10	group	group	NN
cord-006860-a3b8hyyr	1623	11	vs.	vs.	IN
cord-006860-a3b8hyyr	1623	12	the	the	DT
cord-006860-a3b8hyyr	1623	13	other	other	JJ
cord-006860-a3b8hyyr	1623	14	groups	group	NNS
cord-006860-a3b8hyyr	1623	15	(	(	-LRB-
cord-006860-a3b8hyyr	1623	16	lO	lO	NNP
cord-006860-a3b8hyyr	1623	17	rain	rain	NN
cord-006860-a3b8hyyr	1623	18	.	.	.
cord-006860-a3b8hyyr	1624	1	after	after	IN
cord-006860-a3b8hyyr	1624	2	application	application	NN
cord-006860-a3b8hyyr	1624	3	of	of	IN
cord-006860-a3b8hyyr	1624	4	the	the	DT
cord-006860-a3b8hyyr	1624	5	retransfnsed	retransfnse	VBN
cord-006860-a3b8hyyr	1624	6	blood	blood	NN
cord-006860-a3b8hyyr	1624	7	)	)	-RRB-
cord-006860-a3b8hyyr	1624	8	.	.	.
cord-006860-a3b8hyyr	1625	1	Low	low	JJ
cord-006860-a3b8hyyr	1625	2	heparin	heparin	NN
cord-006860-a3b8hyyr	1625	3	concentrations	concentration	NNS
cord-006860-a3b8hyyr	1625	4	of	of	IN
cord-006860-a3b8hyyr	1625	5	retransfused	retransfused	JJ
cord-006860-a3b8hyyr	1625	6	blood	blood	NN
cord-006860-a3b8hyyr	1625	7	in	in	IN
cord-006860-a3b8hyyr	1625	8	the	the	DT
cord-006860-a3b8hyyr	1625	9	HCS	HCS	NNP
cord-006860-a3b8hyyr	1625	10	III	III	NNP
cord-006860-a3b8hyyr	1625	11	group	group	NN
cord-006860-a3b8hyyr	1625	12	(	(	-LRB-
cord-006860-a3b8hyyr	1625	13	0.32	0.32	CD
cord-006860-a3b8hyyr	1625	14	+	+	SYM
cord-006860-a3b8hyyr	1625	15	-0.3	-0.3	NNP
cord-006860-a3b8hyyr	1625	16	U	U	NNP
cord-006860-a3b8hyyr	1625	17	/	/	SYM
cord-006860-a3b8hyyr	1625	18	ml	ml	NN
cord-006860-a3b8hyyr	1625	19	)	)	-RRB-
cord-006860-a3b8hyyr	1625	20	vs.	vs.	IN
cord-006860-a3b8hyyr	1625	21	high	high	JJ
cord-006860-a3b8hyyr	1625	22	concentrations	concentration	NNS
cord-006860-a3b8hyyr	1625	23	in	in	IN
cord-006860-a3b8hyyr	1625	24	the	the	DT
cord-006860-a3b8hyyr	1625	25	CATS	CATS	NNP
cord-006860-a3b8hyyr	1625	26	group	group	NN
cord-006860-a3b8hyyr	1625	27	(	(	-LRB-
cord-006860-a3b8hyyr	1625	28	0.47	0.47	CD
cord-006860-a3b8hyyr	1625	29	+	+	CC
cord-006860-a3b8hyyr	1625	30	-0.3;p--0.01	-0.3;p--0.01	NNP
cord-006860-a3b8hyyr	1625	31	)	)	-RRB-
cord-006860-a3b8hyyr	1625	32	.	.	.
cord-006860-a3b8hyyr	1626	1	Parameters	parameter	NNS
cord-006860-a3b8hyyr	1626	2	of	of	IN
cord-006860-a3b8hyyr	1626	3	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1626	4	generation	generation	NN
cord-006860-a3b8hyyr	1626	5	were	be	VBD
cord-006860-a3b8hyyr	1626	6	elevated	elevate	VBN
cord-006860-a3b8hyyr	1626	7	in	in	IN
cord-006860-a3b8hyyr	1626	8	the	the	DT
cord-006860-a3b8hyyr	1626	9	HCS	HCS	NNP
cord-006860-a3b8hyyr	1626	10	III	III	NNP
cord-006860-a3b8hyyr	1626	11	group	group	NN
cord-006860-a3b8hyyr	1626	12	vs.	vs.	IN
cord-006860-a3b8hyyr	1626	13	the	the	DT
cord-006860-a3b8hyyr	1626	14	other	other	JJ
cord-006860-a3b8hyyr	1626	15	groups	group	NNS
cord-006860-a3b8hyyr	1626	16	(	(	-LRB-
cord-006860-a3b8hyyr	1626	17	p=0.02	p=0.02	NNP
cord-006860-a3b8hyyr	1626	18	)	)	-RRB-
cord-006860-a3b8hyyr	1626	19	.	.	.
cord-006860-a3b8hyyr	1627	1	Conclusions	conclusion	NNS
cord-006860-a3b8hyyr	1627	2	:	:	:
cord-006860-a3b8hyyr	1628	1	The	the	DT
cord-006860-a3b8hyyr	1628	2	use	use	NN
cord-006860-a3b8hyyr	1628	3	of	of	IN
cord-006860-a3b8hyyr	1628	4	5	5	CD
cord-006860-a3b8hyyr	1628	5	different	different	JJ
cord-006860-a3b8hyyr	1628	6	apparative	apparative	NNP
cord-006860-a3b8hyyr	1628	7	autotransfnsion	autotransfnsion	NN
cord-006860-a3b8hyyr	1628	8	systems	system	NNS
cord-006860-a3b8hyyr	1628	9	dunng	dunng	JJ
cord-006860-a3b8hyyr	1628	10	elective	elective	JJ
cord-006860-a3b8hyyr	1628	11	hip	hip	NN
cord-006860-a3b8hyyr	1628	12	surgery	surgery	NN
cord-006860-a3b8hyyr	1628	13	results	result	NNS
cord-006860-a3b8hyyr	1628	14	in	in	IN
cord-006860-a3b8hyyr	1628	15	dysturbances	dysturbance	NNS
cord-006860-a3b8hyyr	1628	16	of	of	IN
cord-006860-a3b8hyyr	1628	17	hemocompatibility	hemocompatibility	NN
cord-006860-a3b8hyyr	1628	18	.	.	.
cord-006860-a3b8hyyr	1629	1	The	the	DT
cord-006860-a3b8hyyr	1629	2	activation	activation	NN
cord-006860-a3b8hyyr	1629	3	of	of	IN
cord-006860-a3b8hyyr	1629	4	the	the	DT
cord-006860-a3b8hyyr	1629	5	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1629	6	system	system	NN
cord-006860-a3b8hyyr	1629	7	during	during	IN
cord-006860-a3b8hyyr	1629	8	the	the	DT
cord-006860-a3b8hyyr	1629	9	collection	collection	NN
cord-006860-a3b8hyyr	1629	10	and	and	CC
cord-006860-a3b8hyyr	1629	11	filtering	filtering	NN
cord-006860-a3b8hyyr	1629	12	is	be	VBZ
cord-006860-a3b8hyyr	1629	13	partly	partly	RB
cord-006860-a3b8hyyr	1629	14	influenced	influence	VBN
cord-006860-a3b8hyyr	1629	15	by	by	IN
cord-006860-a3b8hyyr	1629	16	the	the	DT
cord-006860-a3b8hyyr	1629	17	elimination	elimination	NN
cord-006860-a3b8hyyr	1629	18	kinetics	kinetic	NNS
cord-006860-a3b8hyyr	1629	19	and	and	CC
cord-006860-a3b8hyyr	1629	20	the	the	DT
cord-006860-a3b8hyyr	1629	21	dose	dose	JJ
cord-006860-a3b8hyyr	1629	22	regime	regime	NN
cord-006860-a3b8hyyr	1629	23	of	of	IN
cord-006860-a3b8hyyr	1629	24	heparin	heparin	NN
cord-006860-a3b8hyyr	1629	25	.	.	.
cord-006860-a3b8hyyr	1630	1	However	however	RB
cord-006860-a3b8hyyr	1630	2	intraoperative	intraoperative	JJ
cord-006860-a3b8hyyr	1630	3	autotransfusion	autotransfusion	NN
cord-006860-a3b8hyyr	1630	4	must	must	MD
cord-006860-a3b8hyyr	1630	5	be	be	VB
cord-006860-a3b8hyyr	1630	6	roan	roan	NNP
cord-006860-a3b8hyyr	1630	7	~	~	NFP
cord-006860-a3b8hyyr	1630	8	ged	ged	NNP
cord-006860-a3b8hyyr	1630	9	very	very	RB
cord-006860-a3b8hyyr	1630	10	carefully	carefully	RB
cord-006860-a3b8hyyr	1630	11	and	and	CC
cord-006860-a3b8hyyr	1630	12	possibly	possibly	RB
cord-006860-a3b8hyyr	1630	13	adverse	adverse	JJ
cord-006860-a3b8hyyr	1630	14	effects	effect	NNS
cord-006860-a3b8hyyr	1630	15	of	of	IN
cord-006860-a3b8hyyr	1630	16	perioperadve	perioperadve	NNP
cord-006860-a3b8hyyr	1630	17	heparin	heparin	NN
cord-006860-a3b8hyyr	1630	18	peak	peak	NN
cord-006860-a3b8hyyr	1630	19	levels	level	NNS
cord-006860-a3b8hyyr	1630	20	have	have	VBP
cord-006860-a3b8hyyr	1630	21	to	to	TO
cord-006860-a3b8hyyr	1630	22	be	be	VB
cord-006860-a3b8hyyr	1630	23	considered	consider	VBN
cord-006860-a3b8hyyr	1630	24	.	.	.
cord-006860-a3b8hyyr	1631	1	Little	little	JJ
cord-006860-a3b8hyyr	1631	2	information	information	NN
cord-006860-a3b8hyyr	1631	3	is	be	VBZ
cord-006860-a3b8hyyr	1631	4	available	available	JJ
cord-006860-a3b8hyyr	1631	5	on	on	IN
cord-006860-a3b8hyyr	1631	6	the	the	DT
cord-006860-a3b8hyyr	1631	7	management	management	NN
cord-006860-a3b8hyyr	1631	8	of	of	IN
cord-006860-a3b8hyyr	1631	9	patients	patient	NNS
cord-006860-a3b8hyyr	1631	10	with	with	IN
cord-006860-a3b8hyyr	1631	11	factor	factor	NN
cord-006860-a3b8hyyr	1631	12	VIII	VIII	NNP
cord-006860-a3b8hyyr	1631	13	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1631	14	who	who	WP
cord-006860-a3b8hyyr	1631	15	require	require	VBP
cord-006860-a3b8hyyr	1631	16	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	1631	17	surgery	surgery	NN
cord-006860-a3b8hyyr	1631	18	.	.	.
cord-006860-a3b8hyyr	1632	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1632	2	report	report	VBP
cord-006860-a3b8hyyr	1632	3	the	the	DT
cord-006860-a3b8hyyr	1632	4	case	case	NN
cord-006860-a3b8hyyr	1632	5	of	of	IN
cord-006860-a3b8hyyr	1632	6	a	a	DT
cord-006860-a3b8hyyr	1632	7	54	54	CD
cord-006860-a3b8hyyr	1632	8	year	year	NN
cord-006860-a3b8hyyr	1632	9	old	old	JJ
cord-006860-a3b8hyyr	1632	10	man	man	NN
cord-006860-a3b8hyyr	1632	11	with	with	IN
cord-006860-a3b8hyyr	1632	12	factor	factor	NN
cord-006860-a3b8hyyr	1632	13	VIII	VIII	NNP
cord-006860-a3b8hyyr	1632	14	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1632	15	and	and	CC
cord-006860-a3b8hyyr	1632	16	combined	combine	VBN
cord-006860-a3b8hyyr	1632	17	severe	severe	JJ
cord-006860-a3b8hyyr	1632	18	aortic	aortic	JJ
cord-006860-a3b8hyyr	1632	19	stenosis	stenosis	NN
cord-006860-a3b8hyyr	1632	20	and	and	CC
cord-006860-a3b8hyyr	1632	21	incompetence	incompetence	NN
cord-006860-a3b8hyyr	1632	22	and	and	CC
cord-006860-a3b8hyyr	1632	23	mitral	mitral	JJ
cord-006860-a3b8hyyr	1632	24	incompetence	incompetence	NN
cord-006860-a3b8hyyr	1632	25	who	who	WP
cord-006860-a3b8hyyr	1632	26	underwent	undergo	VBD
cord-006860-a3b8hyyr	1632	27	a	a	DT
cord-006860-a3b8hyyr	1632	28	double	double	JJ
cord-006860-a3b8hyyr	1632	29	valve	valve	NN
cord-006860-a3b8hyyr	1632	30	replacement	replacement	NN
cord-006860-a3b8hyyr	1632	31	at	at	IN
cord-006860-a3b8hyyr	1632	32	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1632	33	institution	institution	NN
cord-006860-a3b8hyyr	1632	34	.	.	.
cord-006860-a3b8hyyr	1633	1	He	-PRON-	PRP
cord-006860-a3b8hyyr	1633	2	had	have	VBD
cord-006860-a3b8hyyr	1633	3	a	a	DT
cord-006860-a3b8hyyr	1633	4	history	history	NN
cord-006860-a3b8hyyr	1633	5	of	of	IN
cord-006860-a3b8hyyr	1633	6	several	several	JJ
cord-006860-a3b8hyyr	1633	7	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1633	8	episodes	episode	NNS
cord-006860-a3b8hyyr	1633	9	following	follow	VBG
cord-006860-a3b8hyyr	1633	10	minor	minor	JJ
cord-006860-a3b8hyyr	1633	11	surgery	surgery	NN
cord-006860-a3b8hyyr	1633	12	.	.	.
cord-006860-a3b8hyyr	1634	1	Previous	previous	JJ
cord-006860-a3b8hyyr	1634	2	factor	factor	NN
cord-006860-a3b8hyyr	1634	3	VIII	VIII	NNP
cord-006860-a3b8hyyr	1634	4	levels	level	NNS
cord-006860-a3b8hyyr	1634	5	were	be	VBD
cord-006860-a3b8hyyr	1634	6	between	between	IN
cord-006860-a3b8hyyr	1634	7	8	8	CD
cord-006860-a3b8hyyr	1634	8	and	and	CC
cord-006860-a3b8hyyr	1634	9	26	26	CD
cord-006860-a3b8hyyr	1634	10	%	%	NN
cord-006860-a3b8hyyr	1634	11	.	.	.
cord-006860-a3b8hyyr	1635	1	Using	use	VBG
cord-006860-a3b8hyyr	1635	2	standard	standard	JJ
cord-006860-a3b8hyyr	1635	3	cardiopulmonary	cardiopulmonary	JJ
cord-006860-a3b8hyyr	1635	4	bypass	bypass	NN
cord-006860-a3b8hyyr	1635	5	,	,	,
cord-006860-a3b8hyyr	1635	6	a	a	DT
cord-006860-a3b8hyyr	1635	7	double	double	JJ
cord-006860-a3b8hyyr	1635	8	valve	valve	NN
cord-006860-a3b8hyyr	1635	9	replacement	replacement	NN
cord-006860-a3b8hyyr	1635	10	with	with	IN
cord-006860-a3b8hyyr	1635	11	a	a	DT
cord-006860-a3b8hyyr	1635	12	23	23	CD
cord-006860-a3b8hyyr	1635	13	and	and	CC
cord-006860-a3b8hyyr	1635	14	29	29	CD
cord-006860-a3b8hyyr	1635	15	mm	mm	CD
cord-006860-a3b8hyyr	1635	16	bileaflet	bileaflet	JJ
cord-006860-a3b8hyyr	1635	17	prosthesis	prosthesis	NN
cord-006860-a3b8hyyr	1635	18	in	in	IN
cord-006860-a3b8hyyr	1635	19	aortic	aortic	JJ
cord-006860-a3b8hyyr	1635	20	and	and	CC
cord-006860-a3b8hyyr	1635	21	mitral	mitral	JJ
cord-006860-a3b8hyyr	1635	22	position	position	NN
cord-006860-a3b8hyyr	1635	23	,	,	,
cord-006860-a3b8hyyr	1635	24	respectively	respectively	RB
cord-006860-a3b8hyyr	1635	25	,	,	,
cord-006860-a3b8hyyr	1635	26	was	be	VBD
cord-006860-a3b8hyyr	1635	27	performed	perform	VBN
cord-006860-a3b8hyyr	1635	28	.	.	.
cord-006860-a3b8hyyr	1636	1	A	a	DT
cord-006860-a3b8hyyr	1636	2	high	high	JJ
cord-006860-a3b8hyyr	1636	3	dose	dose	NN
cord-006860-a3b8hyyr	1636	4	aprotinin	aprotinin	NN
cord-006860-a3b8hyyr	1636	5	regime	regime	NN
cord-006860-a3b8hyyr	1636	6	was	be	VBD
cord-006860-a3b8hyyr	1636	7	used	use	VBN
cord-006860-a3b8hyyr	1636	8	(	(	-LRB-
cord-006860-a3b8hyyr	1636	9	5.5	5.5	CD
cord-006860-a3b8hyyr	1636	10	x	x	SYM
cord-006860-a3b8hyyr	1636	11	10	10	CD
cord-006860-a3b8hyyr	1636	12	a	a	DT
cord-006860-a3b8hyyr	1636	13	IU	IU	NNP
cord-006860-a3b8hyyr	1636	14	)	)	-RRB-
cord-006860-a3b8hyyr	1636	15	.	.	.
cord-006860-a3b8hyyr	1637	1	Three	three	CD
cord-006860-a3b8hyyr	1637	2	doses	dose	NNS
cord-006860-a3b8hyyr	1637	3	of	of	IN
cord-006860-a3b8hyyr	1637	4	factor	factor	NN
cord-006860-a3b8hyyr	1637	5	VIII	VIII	NNP
cord-006860-a3b8hyyr	1637	6	concentrate	concentrate	NN
cord-006860-a3b8hyyr	1637	7	were	be	VBD
cord-006860-a3b8hyyr	1637	8	given	give	VBN
cord-006860-a3b8hyyr	1637	9	in	in	IN
cord-006860-a3b8hyyr	1637	10	the	the	DT
cord-006860-a3b8hyyr	1637	11	perioperative	perioperative	JJ
cord-006860-a3b8hyyr	1637	12	period	period	NN
cord-006860-a3b8hyyr	1637	13	,	,	,
cord-006860-a3b8hyyr	1637	14	totalUng	totalUng	NNP
cord-006860-a3b8hyyr	1637	15	7000	7000	CD
cord-006860-a3b8hyyr	1637	16	1U	1u	NN
cord-006860-a3b8hyyr	1637	17	until	until	IN
cord-006860-a3b8hyyr	1637	18	the	the	DT
cord-006860-a3b8hyyr	1637	19	1st	1st	JJ
cord-006860-a3b8hyyr	1637	20	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	1637	21	day	day	NN
cord-006860-a3b8hyyr	1637	22	.	.	.
cord-006860-a3b8hyyr	1638	1	Repeated	repeat	VBN
cord-006860-a3b8hyyr	1638	2	measurements	measurement	NNS
cord-006860-a3b8hyyr	1638	3	of	of	IN
cord-006860-a3b8hyyr	1638	4	the	the	DT
cord-006860-a3b8hyyr	1638	5	factor	factor	NN
cord-006860-a3b8hyyr	1639	1	VIII	VIII	NNP
cord-006860-a3b8hyyr	1639	2	level	level	NN
cord-006860-a3b8hyyr	1639	3	were	be	VBD
cord-006860-a3b8hyyr	1639	4	performed	perform	VBN
cord-006860-a3b8hyyr	1639	5	.	.	.
cord-006860-a3b8hyyr	1640	1	The	the	DT
cord-006860-a3b8hyyr	1640	2	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	1640	3	chest	chest	NN
cord-006860-a3b8hyyr	1640	4	tube	tube	NN
cord-006860-a3b8hyyr	1640	5	drainage	drainage	NN
cord-006860-a3b8hyyr	1640	6	was	be	VBD
cord-006860-a3b8hyyr	1640	7	350	350	CD
cord-006860-a3b8hyyr	1640	8	rot	rot	NN
cord-006860-a3b8hyyr	1640	9	.	.	.
cord-006860-a3b8hyyr	1641	1	Until	until	IN
cord-006860-a3b8hyyr	1641	2	the	the	DT
cord-006860-a3b8hyyr	1641	3	4th	4th	JJ
cord-006860-a3b8hyyr	1641	4	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	1641	5	day	day	NN
cord-006860-a3b8hyyr	1641	6	an	an	DT
cord-006860-a3b8hyyr	1641	7	additional	additional	JJ
cord-006860-a3b8hyyr	1641	8	dose	dose	NN
cord-006860-a3b8hyyr	1641	9	of	of	IN
cord-006860-a3b8hyyr	1641	10	3000	3000	CD
cord-006860-a3b8hyyr	1641	11	IU	IU	NNP
cord-006860-a3b8hyyr	1641	12	of	of	IN
cord-006860-a3b8hyyr	1641	13	factor	factor	NN
cord-006860-a3b8hyyr	1641	14	VIII	VIII	NNP
cord-006860-a3b8hyyr	1641	15	was	be	VBD
cord-006860-a3b8hyyr	1641	16	given	give	VBN
cord-006860-a3b8hyyr	1641	17	to	to	TO
cord-006860-a3b8hyyr	1641	18	maintain	maintain	VB
cord-006860-a3b8hyyr	1641	19	a	a	DT
cord-006860-a3b8hyyr	1641	20	level	level	NN
cord-006860-a3b8hyyr	1641	21	of	of	IN
cord-006860-a3b8hyyr	1641	22	at	at	RB
cord-006860-a3b8hyyr	1641	23	least	least	RBS
cord-006860-a3b8hyyr	1641	24	30	30	CD
cord-006860-a3b8hyyr	1641	25	%	%	NN
cord-006860-a3b8hyyr	1641	26	.	.	.
cord-006860-a3b8hyyr	1642	1	The	the	DT
cord-006860-a3b8hyyr	1642	2	obligatory	obligatory	JJ
cord-006860-a3b8hyyr	1642	3	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	1642	4	was	be	VBD
cord-006860-a3b8hyyr	1642	5	achieved	achieve	VBN
cord-006860-a3b8hyyr	1642	6	initially	initially	RB
cord-006860-a3b8hyyr	1642	7	with	with	IN
cord-006860-a3b8hyyr	1642	8	heparin	heparin	NNP
cord-006860-a3b8hyyr	1642	9	i.v	i.v	NNP
cord-006860-a3b8hyyr	1642	10	.	.	.
cord-006860-a3b8hyyr	1643	1	in	in	IN
cord-006860-a3b8hyyr	1643	2	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	1643	3	dosage	dosage	NN
cord-006860-a3b8hyyr	1643	4	.	.	.
cord-006860-a3b8hyyr	1644	1	Due	due	IN
cord-006860-a3b8hyyr	1644	2	to	to	IN
cord-006860-a3b8hyyr	1644	3	a	a	DT
cord-006860-a3b8hyyr	1644	4	persistent	persistent	JJ
cord-006860-a3b8hyyr	1644	5	3rd	3rd	JJ
cord-006860-a3b8hyyr	1644	6	degree	degree	NN
cord-006860-a3b8hyyr	1644	7	AV	av	NN
cord-006860-a3b8hyyr	1644	8	block	block	NN
cord-006860-a3b8hyyr	1644	9	a	a	DT
cord-006860-a3b8hyyr	1644	10	permanent	permanent	JJ
cord-006860-a3b8hyyr	1644	11	pacemaker	pacemaker	NN
cord-006860-a3b8hyyr	1644	12	was	be	VBD
cord-006860-a3b8hyyr	1644	13	inserted	insert	VBN
cord-006860-a3b8hyyr	1644	14	with	with	IN
cord-006860-a3b8hyyr	1644	15	additional	additional	JJ
cord-006860-a3b8hyyr	1644	16	2000	2000	CD
cord-006860-a3b8hyyr	1644	17	IU	IU	NNP
cord-006860-a3b8hyyr	1644	18	of	of	IN
cord-006860-a3b8hyyr	1644	19	factor	factor	NN
cord-006860-a3b8hyyr	1644	20	VIII	VIII	NNP
cord-006860-a3b8hyyr	1644	21	.	.	.
cord-006860-a3b8hyyr	1645	1	On	on	IN
cord-006860-a3b8hyyr	1645	2	the	the	DT
cord-006860-a3b8hyyr	1645	3	17th	17th	JJ
cord-006860-a3b8hyyr	1645	4	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	1645	5	day	day	NN
cord-006860-a3b8hyyr	1645	6	Warfarin	Warfarin	NNP
cord-006860-a3b8hyyr	1645	7	was	be	VBD
cord-006860-a3b8hyyr	1645	8	commenced	commence	VBN
cord-006860-a3b8hyyr	1645	9	aiming	aim	VBG
cord-006860-a3b8hyyr	1645	10	for	for	IN
cord-006860-a3b8hyyr	1645	11	an	an	DT
cord-006860-a3b8hyyr	1645	12	INR	INR	NNP
cord-006860-a3b8hyyr	1645	13	of	of	IN
cord-006860-a3b8hyyr	1645	14	3.0	3.0	CD
cord-006860-a3b8hyyr	1645	15	-3.5	-3.5	NNP
cord-006860-a3b8hyyr	1645	16	.	.	.
cord-006860-a3b8hyyr	1646	1	The	the	DT
cord-006860-a3b8hyyr	1646	2	patient	patient	NN
cord-006860-a3b8hyyr	1646	3	was	be	VBD
cord-006860-a3b8hyyr	1646	4	discharged	discharge	VBN
cord-006860-a3b8hyyr	1646	5	home	home	RB
cord-006860-a3b8hyyr	1646	6	thereaRer	thereaRer	NNS
cord-006860-a3b8hyyr	1646	7	.	.	.
cord-006860-a3b8hyyr	1647	1	He	-PRON-	PRP
cord-006860-a3b8hyyr	1647	2	was	be	VBD
cord-006860-a3b8hyyr	1647	3	trained	train	VBN
cord-006860-a3b8hyyr	1647	4	to	to	TO
cord-006860-a3b8hyyr	1647	5	monitor	monitor	VB
cord-006860-a3b8hyyr	1647	6	his	-PRON-	PRP$
cord-006860-a3b8hyyr	1647	7	INR	INR	NNP
cord-006860-a3b8hyyr	1647	8	with	with	IN
cord-006860-a3b8hyyr	1647	9	a	a	DT
cord-006860-a3b8hyyr	1647	10	Coagu	Coagu	NNP
cord-006860-a3b8hyyr	1647	11	Chek	Chek	NNP
cord-006860-a3b8hyyr	1647	12	device	device	NN
cord-006860-a3b8hyyr	1647	13	.	.	.
cord-006860-a3b8hyyr	1648	1	No	no	DT
cord-006860-a3b8hyyr	1648	2	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	1648	3	episode	episode	NN
cord-006860-a3b8hyyr	1648	4	occurred	occur	VBD
cord-006860-a3b8hyyr	1648	5	during	during	IN
cord-006860-a3b8hyyr	1648	6	the	the	DT
cord-006860-a3b8hyyr	1648	7	first	first	JJ
cord-006860-a3b8hyyr	1648	8	3	3	CD
cord-006860-a3b8hyyr	1648	9	months	month	NNS
cord-006860-a3b8hyyr	1648	10	follow	follow	VB
cord-006860-a3b8hyyr	1648	11	up	up	RP
cord-006860-a3b8hyyr	1648	12	.	.	.
cord-006860-a3b8hyyr	1649	1	Open	open	JJ
cord-006860-a3b8hyyr	1649	2	heart	heart	NN
cord-006860-a3b8hyyr	1649	3	surgery	surgery	NN
cord-006860-a3b8hyyr	1649	4	can	can	MD
cord-006860-a3b8hyyr	1649	5	be	be	VB
cord-006860-a3b8hyyr	1649	6	performed	perform	VBN
cord-006860-a3b8hyyr	1649	7	safely	safely	RB
cord-006860-a3b8hyyr	1649	8	in	in	IN
cord-006860-a3b8hyyr	1649	9	patients	patient	NNS
cord-006860-a3b8hyyr	1649	10	with	with	IN
cord-006860-a3b8hyyr	1649	11	factor	factor	NN
cord-006860-a3b8hyyr	1649	12	VIII	VIII	NNP
cord-006860-a3b8hyyr	1649	13	deficiency	deficiency	NN
cord-006860-a3b8hyyr	1649	14	with	with	IN
cord-006860-a3b8hyyr	1649	15	the	the	DT
cord-006860-a3b8hyyr	1649	16	use	use	NN
cord-006860-a3b8hyyr	1649	17	of	of	IN
cord-006860-a3b8hyyr	1649	18	factor	factor	NN
cord-006860-a3b8hyyr	1649	19	VIII	VIII	NNP
cord-006860-a3b8hyyr	1649	20	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	1649	21	and	and	CC
cord-006860-a3b8hyyr	1649	22	monitoring	monitoring	NN
cord-006860-a3b8hyyr	1649	23	of	of	IN
cord-006860-a3b8hyyr	1649	24	factor	factor	NN
cord-006860-a3b8hyyr	1649	25	VIII	VIII	NNP
cord-006860-a3b8hyyr	1649	26	levels	level	NNS
cord-006860-a3b8hyyr	1649	27	.	.	.
cord-006860-a3b8hyyr	1650	1	Coating	coating	NN
cord-006860-a3b8hyyr	1650	2	of	of	IN
cord-006860-a3b8hyyr	1650	3	biomaterials	biomaterial	NNS
cord-006860-a3b8hyyr	1650	4	was	be	VBD
cord-006860-a3b8hyyr	1650	5	developed	develop	VBN
cord-006860-a3b8hyyr	1650	6	using	use	VBG
cord-006860-a3b8hyyr	1650	7	synthetic	synthetic	JJ
cord-006860-a3b8hyyr	1650	8	polymers	polymer	NNS
cord-006860-a3b8hyyr	1650	9	with	with	IN
cord-006860-a3b8hyyr	1650	10	incorporated	incorporate	VBN
cord-006860-a3b8hyyr	1650	11	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	1650	12	.	.	.
cord-006860-a3b8hyyr	1651	1	Stents	stent	NNS
cord-006860-a3b8hyyr	1651	2	were	be	VBD
cord-006860-a3b8hyyr	1651	3	coated	coat	VBN
cord-006860-a3b8hyyr	1651	4	with	with	IN
cord-006860-a3b8hyyr	1651	5	a	a	DT
cord-006860-a3b8hyyr	1651	6	thin	thin	JJ
cord-006860-a3b8hyyr	1651	7	layer	layer	NN
cord-006860-a3b8hyyr	1651	8	consisting	consist	VBG
cord-006860-a3b8hyyr	1651	9	of	of	IN
cord-006860-a3b8hyyr	1651	10	a	a	DT
cord-006860-a3b8hyyr	1651	11	polylactide	polylactide	NN
cord-006860-a3b8hyyr	1651	12	polymer	polymer	NN
cord-006860-a3b8hyyr	1651	13	containing	contain	VBG
cord-006860-a3b8hyyr	1651	14	PEG	PEG	NNP
cord-006860-a3b8hyyr	1651	15	-	-	HYPH
cord-006860-a3b8hyyr	1651	16	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	1651	17	and	and	CC
cord-006860-a3b8hyyr	1651	18	a	a	DT
cord-006860-a3b8hyyr	1651	19	stable	stable	JJ
cord-006860-a3b8hyyr	1651	20	prostacyclin	prostacyclin	JJ
cord-006860-a3b8hyyr	1651	21	analogue	analogue	NN
cord-006860-a3b8hyyr	1651	22	.	.	.
cord-006860-a3b8hyyr	1652	1	These	these	DT
cord-006860-a3b8hyyr	1652	2	materials	material	NNS
cord-006860-a3b8hyyr	1652	3	were	be	VBD
cord-006860-a3b8hyyr	1652	4	tested	test	VBN
cord-006860-a3b8hyyr	1652	5	with	with	IN
cord-006860-a3b8hyyr	1652	6	a	a	DT
cord-006860-a3b8hyyr	1652	7	,	,	,
cord-006860-a3b8hyyr	1652	8	,	,	,
cord-006860-a3b8hyyr	1652	9	human	human	JJ
cord-006860-a3b8hyyr	1652	10	shunt	shunt	NN
cord-006860-a3b8hyyr	1652	11	model	model	NN
cord-006860-a3b8hyyr	1652	12	"	"	''
cord-006860-a3b8hyyr	1652	13	using	use	VBG
cord-006860-a3b8hyyr	1652	14	nonant	nonant	NN
cord-006860-a3b8hyyr	1652	15	/	/	SYM
cord-006860-a3b8hyyr	1652	16	coagulated	coagulate	VBN
cord-006860-a3b8hyyr	1652	17	blood	blood	NN
cord-006860-a3b8hyyr	1652	18	of	of	IN
cord-006860-a3b8hyyr	1652	19	healthy	healthy	JJ
cord-006860-a3b8hyyr	1652	20	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	1652	21	.	.	.
cord-006860-a3b8hyyr	1653	1	Within	within	IN
cord-006860-a3b8hyyr	1653	2	minutes	minute	NNS
cord-006860-a3b8hyyr	1653	3	uncoated	uncoate	VBN
cord-006860-a3b8hyyr	1653	4	stents	stent	NNS
cord-006860-a3b8hyyr	1653	5	were	be	VBD
cord-006860-a3b8hyyr	1653	6	covered	cover	VBN
cord-006860-a3b8hyyr	1653	7	by	by	IN
cord-006860-a3b8hyyr	1653	8	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1653	9	and	and	CC
cord-006860-a3b8hyyr	1653	10	aggregated	aggregated	JJ
cord-006860-a3b8hyyr	1653	11	platelets	platelet	NNS
cord-006860-a3b8hyyr	1653	12	,	,	,
cord-006860-a3b8hyyr	1653	13	which	which	WDT
cord-006860-a3b8hyyr	1653	14	could	could	MD
cord-006860-a3b8hyyr	1653	15	be	be	VB
cord-006860-a3b8hyyr	1653	16	seen	see	VBN
cord-006860-a3b8hyyr	1653	17	macroscopically	macroscopically	RB
cord-006860-a3b8hyyr	1653	18	and	and	CC
cord-006860-a3b8hyyr	1653	19	by	by	IN
cord-006860-a3b8hyyr	1653	20	scanning	scan	VBG
cord-006860-a3b8hyyr	1653	21	electron	electron	NN
cord-006860-a3b8hyyr	1653	22	microscopy	microscopy	NNS
cord-006860-a3b8hyyr	1653	23	;	;	,
cord-006860-a3b8hyyr	1653	24	coated	coated	JJ
cord-006860-a3b8hyyr	1653	25	stents	stent	NNS
cord-006860-a3b8hyyr	1653	26	were	be	VBD
cord-006860-a3b8hyyr	1653	27	free	free	JJ
cord-006860-a3b8hyyr	1653	28	from	from	IN
cord-006860-a3b8hyyr	1653	29	coaguiation	coaguiation	NN
cord-006860-a3b8hyyr	1653	30	plugs	plug	NNS
cord-006860-a3b8hyyr	1653	31	.	.	.
cord-006860-a3b8hyyr	1654	1	This	this	DT
cord-006860-a3b8hyyr	1654	2	observations	observation	NNS
cord-006860-a3b8hyyr	1654	3	were	be	VBD
cord-006860-a3b8hyyr	1654	4	supported	support	VBN
cord-006860-a3b8hyyr	1654	5	by	by	IN
cord-006860-a3b8hyyr	1654	6	analysis	analysis	NN
cord-006860-a3b8hyyr	1654	7	of	of	IN
cord-006860-a3b8hyyr	1654	8	coagulatiuon	coagulatiuon	JJ
cord-006860-a3b8hyyr	1654	9	activation	activation	NN
cord-006860-a3b8hyyr	1654	10	markers	marker	NNS
cord-006860-a3b8hyyr	1654	11	.	.	.
cord-006860-a3b8hyyr	1655	1	Unlike	unlike	IN
cord-006860-a3b8hyyr	1655	2	coated	coated	JJ
cord-006860-a3b8hyyr	1655	3	stents	stent	NNS
cord-006860-a3b8hyyr	1655	4	,	,	,
cord-006860-a3b8hyyr	1655	5	uncoated	uncoated	JJ
cord-006860-a3b8hyyr	1655	6	stents	stent	NNS
cord-006860-a3b8hyyr	1655	7	revealed	reveal	VBD
cord-006860-a3b8hyyr	1655	8	high	high	JJ
cord-006860-a3b8hyyr	1655	9	levels	level	NNS
cord-006860-a3b8hyyr	1655	10	(	(	-LRB-
cord-006860-a3b8hyyr	1655	11	>	>	XX
cord-006860-a3b8hyyr	1655	12	detection	detection	NN
cord-006860-a3b8hyyr	1655	13	limit	limit	NN
cord-006860-a3b8hyyr	1655	14	)	)	-RRB-
cord-006860-a3b8hyyr	1655	15	of	of	IN
cord-006860-a3b8hyyr	1655	16	TAT	tat	NN
cord-006860-a3b8hyyr	1655	17	complexes	complex	NNS
cord-006860-a3b8hyyr	1655	18	and	and	CC
cord-006860-a3b8hyyr	1655	19	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	1655	20	fragments	fragment	NNS
cord-006860-a3b8hyyr	1655	21	(	(	-LRB-
cord-006860-a3b8hyyr	1655	22	F1	F1	NNP
cord-006860-a3b8hyyr	1655	23	-	-	HYPH
cord-006860-a3b8hyyr	1655	24	2	2	CD
cord-006860-a3b8hyyr	1655	25	)	)	-RRB-
cord-006860-a3b8hyyr	1655	26	.	.	.
cord-006860-a3b8hyyr	1656	1	In	in	IN
cord-006860-a3b8hyyr	1656	2	a	a	DT
cord-006860-a3b8hyyr	1656	3	series	series	NN
cord-006860-a3b8hyyr	1656	4	of	of	IN
cord-006860-a3b8hyyr	1656	5	experiments	experiment	NNS
cord-006860-a3b8hyyr	1656	6	stents	stent	NNS
cord-006860-a3b8hyyr	1656	7	were	be	VBD
cord-006860-a3b8hyyr	1656	8	tested	test	VBN
cord-006860-a3b8hyyr	1656	9	in	in	IN
cord-006860-a3b8hyyr	1656	10	sheep	sheep	NNS
cord-006860-a3b8hyyr	1656	11	.	.	.
cord-006860-a3b8hyyr	1657	1	In	in	IN
cord-006860-a3b8hyyr	1657	2	16	16	CD
cord-006860-a3b8hyyr	1657	3	sheep	sheep	NN
cord-006860-a3b8hyyr	1657	4	stents	stent	NNS
cord-006860-a3b8hyyr	1657	5	(	(	-LRB-
cord-006860-a3b8hyyr	1657	6	coated	coated	JJ
cord-006860-a3b8hyyr	1657	7	/	/	SYM
cord-006860-a3b8hyyr	1657	8	uncoated	uncoated	JJ
cord-006860-a3b8hyyr	1657	9	Patmaz	Patmaz	NNP
cord-006860-a3b8hyyr	1657	10	-	-	HYPH
cord-006860-a3b8hyyr	1657	11	Schatz	Schatz	NNP
cord-006860-a3b8hyyr	1657	12	stents	stent	NNS
cord-006860-a3b8hyyr	1657	13	)	)	-RRB-
cord-006860-a3b8hyyr	1657	14	were	be	VBD
cord-006860-a3b8hyyr	1657	15	ptaced	ptace	VBN
cord-006860-a3b8hyyr	1657	16	by	by	IN
cord-006860-a3b8hyyr	1657	17	conventional	conventional	JJ
cord-006860-a3b8hyyr	1657	18	techniques	technique	NNS
cord-006860-a3b8hyyr	1657	19	in	in	IN
cord-006860-a3b8hyyr	1657	20	the	the	DT
cord-006860-a3b8hyyr	1657	21	left	left	JJ
cord-006860-a3b8hyyr	1657	22	anterior	anterior	JJ
cord-006860-a3b8hyyr	1657	23	descending	descend	VBG
cord-006860-a3b8hyyr	1657	24	artery	artery	NN
cord-006860-a3b8hyyr	1657	25	.	.	.
cord-006860-a3b8hyyr	1658	1	Anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	1658	2	therapy	therapy	NN
cord-006860-a3b8hyyr	1658	3	consisted	consist	VBD
cord-006860-a3b8hyyr	1658	4	of	of	IN
cord-006860-a3b8hyyr	1658	5	a	a	DT
cord-006860-a3b8hyyr	1658	6	heparin	heparin	JJ
cord-006860-a3b8hyyr	1658	7	bolus	bolus	NN
cord-006860-a3b8hyyr	1658	8	and	and	CC
cord-006860-a3b8hyyr	1658	9	intravenously	intravenously	RB
cord-006860-a3b8hyyr	1658	10	given	give	VBN
cord-006860-a3b8hyyr	1658	11	aspirin	aspirin	NN
cord-006860-a3b8hyyr	1658	12	before	before	IN
cord-006860-a3b8hyyr	1658	13	stent	stent	JJ
cord-006860-a3b8hyyr	1658	14	implantation	implantation	NN
cord-006860-a3b8hyyr	1658	15	.	.	.
cord-006860-a3b8hyyr	1659	1	No	no	DT
cord-006860-a3b8hyyr	1659	2	ant	ant	NN
cord-006860-a3b8hyyr	1659	3	/	/	SYM
cord-006860-a3b8hyyr	1659	4	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1659	5	was	be	VBD
cord-006860-a3b8hyyr	1659	6	given	give	VBN
cord-006860-a3b8hyyr	1659	7	thereafter	thereafter	RB
cord-006860-a3b8hyyr	1659	8	.	.	.
cord-006860-a3b8hyyr	1660	1	Existing	exist	VBG
cord-006860-a3b8hyyr	1660	2	data	datum	NNS
cord-006860-a3b8hyyr	1660	3	show	show	VBP
cord-006860-a3b8hyyr	1660	4	hyperplasia	hyperplasia	NN
cord-006860-a3b8hyyr	1660	5	in	in	IN
cord-006860-a3b8hyyr	1660	6	the	the	DT
cord-006860-a3b8hyyr	1660	7	area	area	NN
cord-006860-a3b8hyyr	1660	8	of	of	IN
cord-006860-a3b8hyyr	1660	9	uncoated	uncoated	JJ
cord-006860-a3b8hyyr	1660	10	stents	stent	NNS
cord-006860-a3b8hyyr	1660	11	which	which	WDT
cord-006860-a3b8hyyr	1660	12	was	be	VBD
cord-006860-a3b8hyyr	1660	13	reduced	reduce	VBN
cord-006860-a3b8hyyr	1660	14	around	around	IN
cord-006860-a3b8hyyr	1660	15	coated	coat	VBN
cord-006860-a3b8hyyr	1660	16	stents	stent	NNS
cord-006860-a3b8hyyr	1660	17	(	(	-LRB-
cord-006860-a3b8hyyr	1660	18	this	this	DT
cord-006860-a3b8hyyr	1660	19	study	study	NN
cord-006860-a3b8hyyr	1660	20	will	will	MD
cord-006860-a3b8hyyr	1660	21	be	be	VB
cord-006860-a3b8hyyr	1660	22	finished	finish	VBN
cord-006860-a3b8hyyr	1660	23	in	in	IN
cord-006860-a3b8hyyr	1660	24	January	January	NNP
cord-006860-a3b8hyyr	1660	25	1996	1996	CD
cord-006860-a3b8hyyr	1660	26	)	)	-RRB-
cord-006860-a3b8hyyr	1660	27	.	.	.
cord-006860-a3b8hyyr	1661	1	This	this	DT
cord-006860-a3b8hyyr	1661	2	coating	coating	NN
cord-006860-a3b8hyyr	1661	3	technique	technique	NN
cord-006860-a3b8hyyr	1661	4	with	with	IN
cord-006860-a3b8hyyr	1661	5	incorporated	incorporate	VBN
cord-006860-a3b8hyyr	1661	6	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	1661	7	reduces	reduce	VBZ
cord-006860-a3b8hyyr	1661	8	thrombogenicity	thrombogenicity	NN
cord-006860-a3b8hyyr	1661	9	during	during	IN
cord-006860-a3b8hyyr	1661	10	the	the	DT
cord-006860-a3b8hyyr	1661	11	early	early	JJ
cord-006860-a3b8hyyr	1661	12	and	and	CC
cord-006860-a3b8hyyr	1661	13	late	late	JJ
cord-006860-a3b8hyyr	1661	14	phase	phase	NN
cord-006860-a3b8hyyr	1661	15	of	of	IN
cord-006860-a3b8hyyr	1661	16	biomaterial	biomaterial	NN
cord-006860-a3b8hyyr	1661	17	implantation	implantation	NN
cord-006860-a3b8hyyr	1661	18	.	.	.
cord-006860-a3b8hyyr	1662	1	Studies	study	NNS
cord-006860-a3b8hyyr	1662	2	concerning	concern	VBG
cord-006860-a3b8hyyr	1662	3	catheters	catheter	NNS
cord-006860-a3b8hyyr	1662	4	,	,	,
cord-006860-a3b8hyyr	1662	5	vascular	vascular	JJ
cord-006860-a3b8hyyr	1662	6	prosthesis	prosthesis	NN
cord-006860-a3b8hyyr	1662	7	and	and	CC
cord-006860-a3b8hyyr	1662	8	oxygenators	oxygenator	NNS
cord-006860-a3b8hyyr	1662	9	are	be	VBP
cord-006860-a3b8hyyr	1662	10	in	in	IN
cord-006860-a3b8hyyr	1662	11	progress	progress	NN
cord-006860-a3b8hyyr	1662	12	.	.	.
cord-006860-a3b8hyyr	1663	1	The	the	DT
cord-006860-a3b8hyyr	1663	2	mechanical	mechanical	JJ
cord-006860-a3b8hyyr	1663	3	circulatory	circulatory	JJ
cord-006860-a3b8hyyr	1663	4	support	support	NN
cord-006860-a3b8hyyr	1663	5	(	(	-LRB-
cord-006860-a3b8hyyr	1663	6	MCS	MCS	NNP
cord-006860-a3b8hyyr	1663	7	)	)	-RRB-
cord-006860-a3b8hyyr	1663	8	is	be	VBZ
cord-006860-a3b8hyyr	1663	9	a	a	DT
cord-006860-a3b8hyyr	1663	10	therapy	therapy	NN
cord-006860-a3b8hyyr	1663	11	for	for	IN
cord-006860-a3b8hyyr	1663	12	patients	patient	NNS
cord-006860-a3b8hyyr	1663	13	(	(	-LRB-
cord-006860-a3b8hyyr	1663	14	pts	pt	NNS
cord-006860-a3b8hyyr	1663	15	)	)	-RRB-
cord-006860-a3b8hyyr	1663	16	with	with	IN
cord-006860-a3b8hyyr	1663	17	endstage	endstage	NN
cord-006860-a3b8hyyr	1663	18	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	1663	19	insufficiency	insufficiency	NN
cord-006860-a3b8hyyr	1663	20	.	.	.
cord-006860-a3b8hyyr	1664	1	During	during	IN
cord-006860-a3b8hyyr	1664	2	MCS	MCS	NNP
cord-006860-a3b8hyyr	1664	3	thrombeembolic	thrombeembolic	JJ
cord-006860-a3b8hyyr	1664	4	events	event	NNS
cord-006860-a3b8hyyr	1664	5	,	,	,
cord-006860-a3b8hyyr	1664	6	due	due	IN
cord-006860-a3b8hyyr	1664	7	to	to	IN
cord-006860-a3b8hyyr	1664	8	the	the	DT
cord-006860-a3b8hyyr	1664	9	surface	surface	NN
cord-006860-a3b8hyyr	1664	10	thrombogenicity	thrombogenicity	NN
cord-006860-a3b8hyyr	1664	11	of	of	IN
cord-006860-a3b8hyyr	1664	12	the	the	DT
cord-006860-a3b8hyyr	1664	13	implanted	implant	VBN
cord-006860-a3b8hyyr	1664	14	device	device	NN
cord-006860-a3b8hyyr	1664	15	,	,	,
cord-006860-a3b8hyyr	1664	16	are	be	VBP
cord-006860-a3b8hyyr	1664	17	feared	fear	VBN
cord-006860-a3b8hyyr	1664	18	complications	complication	NNS
cord-006860-a3b8hyyr	1664	19	.	.	.
cord-006860-a3b8hyyr	1665	1	Activated	activate	VBN
cord-006860-a3b8hyyr	1665	2	blood	blood	NN
cord-006860-a3b8hyyr	1665	3	platelcts	platelct	NNS
cord-006860-a3b8hyyr	1665	4	play	play	VBP
cord-006860-a3b8hyyr	1665	5	a	a	DT
cord-006860-a3b8hyyr	1665	6	major	major	JJ
cord-006860-a3b8hyyr	1665	7	role	role	NN
cord-006860-a3b8hyyr	1665	8	in	in	IN
cord-006860-a3b8hyyr	1665	9	this	this	DT
cord-006860-a3b8hyyr	1665	10	context	context	NN
cord-006860-a3b8hyyr	1665	11	.	.	.
cord-006860-a3b8hyyr	1666	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	1666	2	,	,	,
cord-006860-a3b8hyyr	1666	3	patient	patient	NNP
cord-006860-a3b8hyyr	1666	4	's	's	POS
cord-006860-a3b8hyyr	1666	5	platelet	platelet	NN
cord-006860-a3b8hyyr	1666	6	morphology	morphology	NN
cord-006860-a3b8hyyr	1666	7	was	be	VBD
cord-006860-a3b8hyyr	1666	8	investigated	investigate	VBN
cord-006860-a3b8hyyr	1666	9	.	.	.
cord-006860-a3b8hyyr	1667	1	During	during	IN
cord-006860-a3b8hyyr	1667	2	the	the	DT
cord-006860-a3b8hyyr	1667	3	period	period	NN
cord-006860-a3b8hyyr	1667	4	of	of	IN
cord-006860-a3b8hyyr	1667	5	MCS	MCS	NNP
cord-006860-a3b8hyyr	1667	6	,	,	,
cord-006860-a3b8hyyr	1667	7	using	use	VBG
cord-006860-a3b8hyyr	1667	8	the	the	DT
cord-006860-a3b8hyyr	1667	9	Novacor	Novacor	NNP
cord-006860-a3b8hyyr	1667	10	left	left	NN
cord-006860-a3b8hyyr	1668	1	ventricular	ventricular	JJ
cord-006860-a3b8hyyr	1668	2	assist	assist	VB
cord-006860-a3b8hyyr	1668	3	system	system	NN
cord-006860-a3b8hyyr	1668	4	N100	N100	NNP
cord-006860-a3b8hyyr	1668	5	,	,	,
cord-006860-a3b8hyyr	1668	6	blood	blood	NN
cord-006860-a3b8hyyr	1668	7	samples	sample	NNS
cord-006860-a3b8hyyr	1668	8	of	of	IN
cord-006860-a3b8hyyr	1668	9	8	8	CD
cord-006860-a3b8hyyr	1668	10	pts	pt	NNS
cord-006860-a3b8hyyr	1668	11	were	be	VBD
cord-006860-a3b8hyyr	1668	12	observed	observe	VBN
cord-006860-a3b8hyyr	1668	13	by	by	IN
cord-006860-a3b8hyyr	1668	14	means	mean	NNS
cord-006860-a3b8hyyr	1668	15	of	of	IN
cord-006860-a3b8hyyr	1668	16	scanning	scan	VBG
cord-006860-a3b8hyyr	1668	17	electron	electron	NN
cord-006860-a3b8hyyr	1668	18	microscopy	microscopy	NN
cord-006860-a3b8hyyr	1668	19	(	(	-LRB-
cord-006860-a3b8hyyr	1668	20	SEM	SEM	NNP
cord-006860-a3b8hyyr	1668	21	)	)	-RRB-
cord-006860-a3b8hyyr	1668	22	.	.	.
cord-006860-a3b8hyyr	1669	1	Blood	blood	NN
cord-006860-a3b8hyyr	1669	2	was	be	VBD
cord-006860-a3b8hyyr	1669	3	collected	collect	VBN
cord-006860-a3b8hyyr	1669	4	preoperatively	preoperatively	NN
cord-006860-a3b8hyyr	1669	5	and	and	CC
cord-006860-a3b8hyyr	1669	6	after	after	IN
cord-006860-a3b8hyyr	1669	7	implantation	implantation	NN
cord-006860-a3b8hyyr	1669	8	daily	daily	RB
cord-006860-a3b8hyyr	1669	9	during	during	IN
cord-006860-a3b8hyyr	1669	10	the	the	DT
cord-006860-a3b8hyyr	1669	11	first	first	JJ
cord-006860-a3b8hyyr	1669	12	week	week	NN
cord-006860-a3b8hyyr	1669	13	as	as	RB
cord-006860-a3b8hyyr	1669	14	well	well	RB
cord-006860-a3b8hyyr	1669	15	as	as	IN
cord-006860-a3b8hyyr	1669	16	weekly	weekly	NN
cord-006860-a3b8hyyr	1669	17	for	for	IN
cord-006860-a3b8hyyr	1669	18	the	the	DT
cord-006860-a3b8hyyr	1669	19	first	first	JJ
cord-006860-a3b8hyyr	1669	20	3	3	CD
cord-006860-a3b8hyyr	1669	21	months	month	NNS
cord-006860-a3b8hyyr	1669	22	.	.	.
cord-006860-a3b8hyyr	1670	1	Samples	sample	NNS
cord-006860-a3b8hyyr	1670	2	were	be	VBD
cord-006860-a3b8hyyr	1670	3	drawn	draw	VBN
cord-006860-a3b8hyyr	1670	4	via	via	IN
cord-006860-a3b8hyyr	1670	5	an	an	DT
cord-006860-a3b8hyyr	1670	6	18gauge	18gauge	CD
cord-006860-a3b8hyyr	1670	7	cannula	cannula	NN
cord-006860-a3b8hyyr	1670	8	into	into	IN
cord-006860-a3b8hyyr	1670	9	caeodylic	caeodylic	NN
cord-006860-a3b8hyyr	1670	10	-	-	HYPH
cord-006860-a3b8hyyr	1670	11	acid	acid	NN
cord-006860-a3b8hyyr	1670	12	buffered	buffer	VBN
cord-006860-a3b8hyyr	1670	13	glutaraldehyde	glutaraldehyde	NN
cord-006860-a3b8hyyr	1670	14	and	and	CC
cord-006860-a3b8hyyr	1670	15	platelets	platelet	NNS
cord-006860-a3b8hyyr	1670	16	were	be	VBD
cord-006860-a3b8hyyr	1670	17	prepared	prepare	VBN
cord-006860-a3b8hyyr	1670	18	for	for	IN
cord-006860-a3b8hyyr	1670	19	morphological	morphological	JJ
cord-006860-a3b8hyyr	1670	20	investigations	investigation	NNS
cord-006860-a3b8hyyr	1670	21	.	.	.
cord-006860-a3b8hyyr	1671	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	1671	2	alterations	alteration	NNS
cord-006860-a3b8hyyr	1671	3	were	be	VBD
cord-006860-a3b8hyyr	1671	4	classified	classify	VBN
cord-006860-a3b8hyyr	1671	5	as	as	IN
cord-006860-a3b8hyyr	1671	6	non	non	NNP
cord-006860-a3b8hyyr	1671	7	activated	activate	VBN
cord-006860-a3b8hyyr	1671	8	,	,	,
cord-006860-a3b8hyyr	1671	9	activated	activate	VBN
cord-006860-a3b8hyyr	1671	10	and	and	CC
cord-006860-a3b8hyyr	1671	11	aggregated	aggregate	VBN
cord-006860-a3b8hyyr	1671	12	,	,	,
cord-006860-a3b8hyyr	1671	13	based	base	VBN
cord-006860-a3b8hyyr	1671	14	on	on	IN
cord-006860-a3b8hyyr	1671	15	"	"	``
cord-006860-a3b8hyyr	1671	16	shape	shape	NN
cord-006860-a3b8hyyr	1671	17	change	change	NN
cord-006860-a3b8hyyr	1671	18	"	"	''
cord-006860-a3b8hyyr	1671	19	morphology	morphology	NN
cord-006860-a3b8hyyr	1671	20	.	.	.
cord-006860-a3b8hyyr	1672	1	Additionally	additionally	RB
cord-006860-a3b8hyyr	1672	2	,	,	,
cord-006860-a3b8hyyr	1672	3	the	the	DT
cord-006860-a3b8hyyr	1672	4	common	common	JJ
cord-006860-a3b8hyyr	1672	5	blood	blood	NN
cord-006860-a3b8hyyr	1672	6	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1672	7	parameters	parameter	NNS
cord-006860-a3b8hyyr	1672	8	were	be	VBD
cord-006860-a3b8hyyr	1672	9	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	1672	10	.	.	.
cord-006860-a3b8hyyr	1673	1	Preoperatively	Preoperatively	NNP
cord-006860-a3b8hyyr	1673	2	,	,	,
cord-006860-a3b8hyyr	1673	3	15.0	15.0	CD
cord-006860-a3b8hyyr	1673	4	+	+	SYM
cord-006860-a3b8hyyr	1673	5	4.6	4.6	CD
cord-006860-a3b8hyyr	1673	6	%	%	NN
cord-006860-a3b8hyyr	1673	7	of	of	IN
cord-006860-a3b8hyyr	1673	8	activated	activate	VBN
cord-006860-a3b8hyyr	1673	9	platelets	platelet	NNS
cord-006860-a3b8hyyr	1673	10	were	be	VBD
cord-006860-a3b8hyyr	1673	11	found	find	VBN
cord-006860-a3b8hyyr	1673	12	.	.	.
cord-006860-a3b8hyyr	1674	1	Within	within	IN
cord-006860-a3b8hyyr	1674	2	the	the	DT
cord-006860-a3b8hyyr	1674	3	first	first	JJ
cord-006860-a3b8hyyr	1674	4	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	1674	5	week	week	NN
cord-006860-a3b8hyyr	1674	6	,	,	,
cord-006860-a3b8hyyr	1674	7	the	the	DT
cord-006860-a3b8hyyr	1674	8	mean	mean	JJ
cord-006860-a3b8hyyr	1674	9	level	level	NN
cord-006860-a3b8hyyr	1674	10	of	of	IN
cord-006860-a3b8hyyr	1674	11	activated	activate	VBN
cord-006860-a3b8hyyr	1674	12	platelets	platelet	NNS
cord-006860-a3b8hyyr	1674	13	raised	raise	VBD
cord-006860-a3b8hyyr	1674	14	to	to	IN
cord-006860-a3b8hyyr	1674	15	32.8	32.8	CD
cord-006860-a3b8hyyr	1674	16	+	+	SYM
cord-006860-a3b8hyyr	1674	17	8.0	8.0	CD
cord-006860-a3b8hyyr	1674	18	%	%	NN
cord-006860-a3b8hyyr	1674	19	(	(	-LRB-
cord-006860-a3b8hyyr	1674	20	p<0.05	p<0.05	CD
cord-006860-a3b8hyyr	1674	21	)	)	-RRB-
cord-006860-a3b8hyyr	1674	22	.	.	.
cord-006860-a3b8hyyr	1675	1	Comparing	compare	VBG
cord-006860-a3b8hyyr	1675	2	short-(<30	short-(<30	NN
cord-006860-a3b8hyyr	1675	3	days	day	NNS
cord-006860-a3b8hyyr	1675	4	)	)	-RRB-
cord-006860-a3b8hyyr	1675	5	vs.	vs.	CC
cord-006860-a3b8hyyr	1675	6	long	long	JJ
cord-006860-a3b8hyyr	1675	7	-	-	HYPH
cord-006860-a3b8hyyr	1675	8	term	term	NN
cord-006860-a3b8hyyr	1675	9	(	(	-LRB-
cord-006860-a3b8hyyr	1675	10	>	>	SYM
cord-006860-a3b8hyyr	1675	11	30	30	CD
cord-006860-a3b8hyyr	1675	12	days	day	NNS
cord-006860-a3b8hyyr	1675	13	)	)	-RRB-
cord-006860-a3b8hyyr	1675	14	MCS	MCS	NNP
cord-006860-a3b8hyyr	1675	15	,	,	,
cord-006860-a3b8hyyr	1675	16	a	a	DT
cord-006860-a3b8hyyr	1675	17	significant	significant	JJ
cord-006860-a3b8hyyr	1675	18	difference	difference	NN
cord-006860-a3b8hyyr	1675	19	of	of	IN
cord-006860-a3b8hyyr	1675	20	activated	activate	VBN
cord-006860-a3b8hyyr	1675	21	ptatelets	ptatelet	NNS
cord-006860-a3b8hyyr	1675	22	(	(	-LRB-
cord-006860-a3b8hyyr	1675	23	overall	overall	JJ
cord-006860-a3b8hyyr	1675	24	mean	mean	JJ
cord-006860-a3b8hyyr	1675	25	values	value	NNS
cord-006860-a3b8hyyr	1675	26	)	)	-RRB-
cord-006860-a3b8hyyr	1675	27	could	could	MD
cord-006860-a3b8hyyr	1675	28	be	be	VB
cord-006860-a3b8hyyr	1675	29	seen	see	VBN
cord-006860-a3b8hyyr	1675	30	(	(	-LRB-
cord-006860-a3b8hyyr	1675	31	24.3	24.3	CD
cord-006860-a3b8hyyr	1675	32	+	+	CC
cord-006860-a3b8hyyr	1675	33	_	_	NN
cord-006860-a3b8hyyr	1675	34	3.3	3.3	CD
cord-006860-a3b8hyyr	1675	35	%	%	NN
cord-006860-a3b8hyyr	1675	36	vs.	vs.	IN
cord-006860-a3b8hyyr	1675	37	34.8	34.8	CD
cord-006860-a3b8hyyr	1675	38	_	_	NN
cord-006860-a3b8hyyr	1675	39	+	+	CC
cord-006860-a3b8hyyr	1675	40	3.4	3.4	CD
cord-006860-a3b8hyyr	1675	41	%	%	NN
cord-006860-a3b8hyyr	1675	42	,	,	,
cord-006860-a3b8hyyr	1675	43	p=0.004	p=0.004	NNP
cord-006860-a3b8hyyr	1675	44	)	)	-RRB-
cord-006860-a3b8hyyr	1675	45	.	.	.
cord-006860-a3b8hyyr	1676	1	During	during	IN
cord-006860-a3b8hyyr	1676	2	MCS	MCS	NNP
cord-006860-a3b8hyyr	1676	3	a	a	DT
cord-006860-a3b8hyyr	1676	4	correlation	correlation	NN
cord-006860-a3b8hyyr	1676	5	between	between	IN
cord-006860-a3b8hyyr	1676	6	hemolysis	hemolysis	NN
cord-006860-a3b8hyyr	1676	7	and	and	CC
cord-006860-a3b8hyyr	1676	8	platelet	platelet	NN
cord-006860-a3b8hyyr	1676	9	aggregates	aggregate	NNS
cord-006860-a3b8hyyr	1676	10	,	,	,
cord-006860-a3b8hyyr	1676	11	as	as	RB
cord-006860-a3b8hyyr	1676	12	well	well	RB
cord-006860-a3b8hyyr	1676	13	as	as	IN
cord-006860-a3b8hyyr	1676	14	the	the	DT
cord-006860-a3b8hyyr	1676	15	values	value	NNS
cord-006860-a3b8hyyr	1676	16	of	of	IN
cord-006860-a3b8hyyr	1676	17	activated	activate	VBN
cord-006860-a3b8hyyr	1676	18	dotting	dotting	NN
cord-006860-a3b8hyyr	1676	19	time	time	NN
cord-006860-a3b8hyyr	1676	20	and	and	CC
cord-006860-a3b8hyyr	1676	21	activated	activate	VBN
cord-006860-a3b8hyyr	1676	22	platelets	platelet	NNS
cord-006860-a3b8hyyr	1676	23	were	be	VBD
cord-006860-a3b8hyyr	1676	24	observed	observe	VBN
cord-006860-a3b8hyyr	1676	25	.	.	.
cord-006860-a3b8hyyr	1677	1	Also	also	RB
cord-006860-a3b8hyyr	1677	2	,	,	,
cord-006860-a3b8hyyr	1677	3	specific	specific	JJ
cord-006860-a3b8hyyr	1677	4	platelet	platelet	NN
cord-006860-a3b8hyyr	1677	5	deformations	deformation	NNS
cord-006860-a3b8hyyr	1677	6	and	and	CC
cord-006860-a3b8hyyr	1677	7	damages	damage	NNS
cord-006860-a3b8hyyr	1677	8	appeared	appear	VBD
cord-006860-a3b8hyyr	1677	9	during	during	IN
cord-006860-a3b8hyyr	1677	10	MCS	MCS	NNP
cord-006860-a3b8hyyr	1677	11	,	,	,
cord-006860-a3b8hyyr	1677	12	which	which	WDT
cord-006860-a3b8hyyr	1677	13	could	could	MD
cord-006860-a3b8hyyr	1677	14	not	not	RB
cord-006860-a3b8hyyr	1677	15	be	be	VB
cord-006860-a3b8hyyr	1677	16	found	find	VBN
cord-006860-a3b8hyyr	1677	17	preoperatively	preoperatively	RB
cord-006860-a3b8hyyr	1677	18	.	.	.
cord-006860-a3b8hyyr	1678	1	All	all	DT
cord-006860-a3b8hyyr	1678	2	pts	pt	NNS
cord-006860-a3b8hyyr	1678	3	with	with	IN
cord-006860-a3b8hyyr	1678	4	MCS	MCS	NNP
cord-006860-a3b8hyyr	1678	5	showed	show	VBD
cord-006860-a3b8hyyr	1678	6	alterations	alteration	NNS
cord-006860-a3b8hyyr	1678	7	of	of	IN
cord-006860-a3b8hyyr	1678	8	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1678	9	platelet	platelet	NN
cord-006860-a3b8hyyr	1678	10	morphology	morphology	NN
cord-006860-a3b8hyyr	1678	11	induced	induce	VBN
cord-006860-a3b8hyyr	1678	12	by	by	IN
cord-006860-a3b8hyyr	1678	13	the	the	DT
cord-006860-a3b8hyyr	1678	14	activation	activation	NN
cord-006860-a3b8hyyr	1678	15	of	of	IN
cord-006860-a3b8hyyr	1678	16	the	the	DT
cord-006860-a3b8hyyr	1678	17	implanted	implant	VBN
cord-006860-a3b8hyyr	1678	18	synthetic	synthetic	JJ
cord-006860-a3b8hyyr	1678	19	material	material	NN
cord-006860-a3b8hyyr	1678	20	.	.	.
cord-006860-a3b8hyyr	1679	1	With	with	IN
cord-006860-a3b8hyyr	1679	2	regard	regard	NN
cord-006860-a3b8hyyr	1679	3	to	to	IN
cord-006860-a3b8hyyr	1679	4	the	the	DT
cord-006860-a3b8hyyr	1679	5	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	1679	6	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	1679	7	therapy	therapy	NN
cord-006860-a3b8hyyr	1679	8	,	,	,
cord-006860-a3b8hyyr	1679	9	these	these	DT
cord-006860-a3b8hyyr	1679	10	observations	observation	NNS
cord-006860-a3b8hyyr	1679	11	should	should	MD
cord-006860-a3b8hyyr	1679	12	be	be	VB
cord-006860-a3b8hyyr	1679	13	taken	take	VBN
cord-006860-a3b8hyyr	1679	14	into	into	IN
cord-006860-a3b8hyyr	1679	15	consideration	consideration	NN
cord-006860-a3b8hyyr	1679	16	.	.	.
cord-006860-a3b8hyyr	1680	1	During	during	IN
cord-006860-a3b8hyyr	1680	2	extracorporeal	extracorporeal	JJ
cord-006860-a3b8hyyr	1680	3	circulation	circulation	NN
cord-006860-a3b8hyyr	1680	4	(	(	-LRB-
cord-006860-a3b8hyyr	1680	5	ECC	ECC	NNP
cord-006860-a3b8hyyr	1680	6	)	)	-RRB-
cord-006860-a3b8hyyr	1680	7	the	the	DT
cord-006860-a3b8hyyr	1680	8	blood	blood	NN
cord-006860-a3b8hyyr	1680	9	and	and	CC
cord-006860-a3b8hyyr	1680	10	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1680	11	compenents	compenent	NNS
cord-006860-a3b8hyyr	1680	12	are	be	VBP
cord-006860-a3b8hyyr	1680	13	exposed	expose	VBN
cord-006860-a3b8hyyr	1680	14	to	to	IN
cord-006860-a3b8hyyr	1680	15	artificial	artificial	JJ
cord-006860-a3b8hyyr	1680	16	surfaces	surface	NNS
cord-006860-a3b8hyyr	1680	17	and	and	CC
cord-006860-a3b8hyyr	1680	18	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	1680	19	respenses	respense	NNS
cord-006860-a3b8hyyr	1680	20	are	be	VBP
cord-006860-a3b8hyyr	1680	21	activated	activate	VBN
cord-006860-a3b8hyyr	1680	22	,	,	,
cord-006860-a3b8hyyr	1680	23	especially	especially	RB
cord-006860-a3b8hyyr	1680	24	the	the	DT
cord-006860-a3b8hyyr	1680	25	complement	complement	NN
cord-006860-a3b8hyyr	1680	26	,	,	,
cord-006860-a3b8hyyr	1680	27	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1680	28	,	,	,
cord-006860-a3b8hyyr	1680	29	fibrinolytic	fibrinolytic	NNP
cord-006860-a3b8hyyr	1680	30	and	and	CC
cord-006860-a3b8hyyr	1680	31	kallikrein	kallikrein	NNP
cord-006860-a3b8hyyr	1680	32	systems	system	NNS
cord-006860-a3b8hyyr	1680	33	.	.	.
cord-006860-a3b8hyyr	1681	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	1681	2	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	1681	3	activation	activation	NN
cord-006860-a3b8hyyr	1681	4	occurs	occur	VBZ
cord-006860-a3b8hyyr	1681	5	and	and	CC
cord-006860-a3b8hyyr	1681	6	platelet	platelet	NN
cord-006860-a3b8hyyr	1681	7	function	function	NN
cord-006860-a3b8hyyr	1681	8	is	be	VBZ
cord-006860-a3b8hyyr	1681	9	impaired	impair	VBN
cord-006860-a3b8hyyr	1681	10	.	.	.
cord-006860-a3b8hyyr	1682	1	These	these	DT
cord-006860-a3b8hyyr	1682	2	humoral	humoral	JJ
cord-006860-a3b8hyyr	1682	3	and	and	CC
cord-006860-a3b8hyyr	1682	4	cellular	cellular	JJ
cord-006860-a3b8hyyr	1682	5	systemic	systemic	JJ
cord-006860-a3b8hyyr	1682	6	responses	response	NNS
cord-006860-a3b8hyyr	1682	7	are	be	VBP
cord-006860-a3b8hyyr	1682	8	known	know	VBN
cord-006860-a3b8hyyr	1682	9	as	as	IN
cord-006860-a3b8hyyr	1682	10	the	the	DT
cord-006860-a3b8hyyr	1682	11	"	"	``
cord-006860-a3b8hyyr	1682	12	pustperfusion	pustperfusion	NNP
cord-006860-a3b8hyyr	1682	13	syndrome	syndrome	NN
cord-006860-a3b8hyyr	1682	14	"	"	''
cord-006860-a3b8hyyr	1682	15	with	with	IN
cord-006860-a3b8hyyr	1682	16	clinical	clinical	JJ
cord-006860-a3b8hyyr	1682	17	symptomes	symptome	NNS
cord-006860-a3b8hyyr	1682	18	like	like	IN
cord-006860-a3b8hyyr	1682	19	lenkocytosis	lenkocytosis	NN
cord-006860-a3b8hyyr	1682	20	,	,	,
cord-006860-a3b8hyyr	1682	21	increased	increase	VBN
cord-006860-a3b8hyyr	1682	22	capillary	capillary	JJ
cord-006860-a3b8hyyr	1682	23	perraeability	perraeability	NN
cord-006860-a3b8hyyr	1682	24	,	,	,
cord-006860-a3b8hyyr	1682	25	accumulation	accumulation	NN
cord-006860-a3b8hyyr	1682	26	of	of	IN
cord-006860-a3b8hyyr	1682	27	interstitial	interstitial	JJ
cord-006860-a3b8hyyr	1682	28	fluid	fluid	NN
cord-006860-a3b8hyyr	1682	29	and	and	CC
cord-006860-a3b8hyyr	1682	30	organ	organ	NN
cord-006860-a3b8hyyr	1682	31	dysfunction	dysfunction	NN
cord-006860-a3b8hyyr	1682	32	.	.	.
cord-006860-a3b8hyyr	1683	1	The	the	DT
cord-006860-a3b8hyyr	1683	2	impertance	impertance	NN
cord-006860-a3b8hyyr	1683	3	and	and	CC
cord-006860-a3b8hyyr	1683	4	even	even	RB
cord-006860-a3b8hyyr	1683	5	perhaps	perhaps	RB
cord-006860-a3b8hyyr	1683	6	the	the	DT
cord-006860-a3b8hyyr	1683	7	existence	existence	NN
cord-006860-a3b8hyyr	1683	8	of	of	IN
cord-006860-a3b8hyyr	1683	9	the	the	DT
cord-006860-a3b8hyyr	1683	10	damaging	damaging	JJ
cord-006860-a3b8hyyr	1683	11	effects	effect	NNS
cord-006860-a3b8hyyr	1683	12	of	of	IN
cord-006860-a3b8hyyr	1683	13	CPB	CPB	NNP
cord-006860-a3b8hyyr	1683	14	have	have	VBP
cord-006860-a3b8hyyr	1683	15	been	be	VBN
cord-006860-a3b8hyyr	1683	16	widely	widely	RB
cord-006860-a3b8hyyr	1683	17	debated	debate	VBN
cord-006860-a3b8hyyr	1683	18	in	in	IN
cord-006860-a3b8hyyr	1683	19	the	the	DT
cord-006860-a3b8hyyr	1683	20	literature	literature	NN
cord-006860-a3b8hyyr	1683	21	over	over	IN
cord-006860-a3b8hyyr	1683	22	the	the	DT
cord-006860-a3b8hyyr	1683	23	past	past	JJ
cord-006860-a3b8hyyr	1683	24	30	30	CD
cord-006860-a3b8hyyr	1683	25	years	year	NNS
cord-006860-a3b8hyyr	1683	26	.	.	.
cord-006860-a3b8hyyr	1684	1	Many	many	JJ
cord-006860-a3b8hyyr	1684	2	efforts	effort	NNS
cord-006860-a3b8hyyr	1684	3	have	have	VBP
cord-006860-a3b8hyyr	1684	4	been	be	VBN
cord-006860-a3b8hyyr	1684	5	made	make	VBN
cord-006860-a3b8hyyr	1684	6	to	to	TO
cord-006860-a3b8hyyr	1684	7	reduce	reduce	VB
cord-006860-a3b8hyyr	1684	8	traumatizing	traumatizing	JJ
cord-006860-a3b8hyyr	1684	9	factors	factor	NNS
cord-006860-a3b8hyyr	1684	10	,	,	,
cord-006860-a3b8hyyr	1684	11	e.g.	e.g.	IN
cord-006860-a3b8hyyr	1684	12	the	the	DT
cord-006860-a3b8hyyr	1684	13	use	use	NN
cord-006860-a3b8hyyr	1684	14	of	of	IN
cord-006860-a3b8hyyr	1684	15	membrane	membrane	NN
cord-006860-a3b8hyyr	1684	16	instead	instead	RB
cord-006860-a3b8hyyr	1684	17	of	of	IN
cord-006860-a3b8hyyr	1684	18	bubble	bubble	NN
cord-006860-a3b8hyyr	1684	19	oxygenators	oxygenator	NNS
cord-006860-a3b8hyyr	1684	20	.	.	.
cord-006860-a3b8hyyr	1685	1	Recently	recently	RB
cord-006860-a3b8hyyr	1685	2	,	,	,
cord-006860-a3b8hyyr	1685	3	heparin	heparin	NN
cord-006860-a3b8hyyr	1685	4	-	-	HYPH
cord-006860-a3b8hyyr	1685	5	coated	coat	VBN
cord-006860-a3b8hyyr	1685	6	equipmen~	equipmen~	NNP
cord-006860-a3b8hyyr	1685	7	and	and	CC
cord-006860-a3b8hyyr	1685	8	tubings	tubing	NNS
cord-006860-a3b8hyyr	1685	9	have	have	VBP
cord-006860-a3b8hyyr	1685	10	been	be	VBN
cord-006860-a3b8hyyr	1685	11	proposed	propose	VBN
cord-006860-a3b8hyyr	1685	12	to	to	TO
cord-006860-a3b8hyyr	1685	13	avoid	avoid	VB
cord-006860-a3b8hyyr	1685	14	excessive	excessive	JJ
cord-006860-a3b8hyyr	1685	15	contact	contact	NN
cord-006860-a3b8hyyr	1685	16	activation	activation	NN
cord-006860-a3b8hyyr	1685	17	during	during	IN
cord-006860-a3b8hyyr	1685	18	CPB	CPB	NNP
cord-006860-a3b8hyyr	1685	19	,	,	,
cord-006860-a3b8hyyr	1685	20	The	the	DT
cord-006860-a3b8hyyr	1685	21	here	here	RB
cord-006860-a3b8hyyr	1685	22	presented	present	VBN
cord-006860-a3b8hyyr	1685	23	study	study	NN
cord-006860-a3b8hyyr	1685	24	was	be	VBD
cord-006860-a3b8hyyr	1685	25	designed	design	VBN
cord-006860-a3b8hyyr	1685	26	to	to	TO
cord-006860-a3b8hyyr	1685	27	assess	assess	VB
cord-006860-a3b8hyyr	1685	28	changes	change	NNS
cord-006860-a3b8hyyr	1685	29	in	in	IN
cord-006860-a3b8hyyr	1685	30	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1685	31	and	and	CC
cord-006860-a3b8hyyr	1685	32	flbrinolytie	flbrinolytie	NN
cord-006860-a3b8hyyr	1685	33	activity	activity	NN
cord-006860-a3b8hyyr	1685	34	in	in	IN
cord-006860-a3b8hyyr	1685	35	20	20	CD
cord-006860-a3b8hyyr	1685	36	patients	patient	NNS
cord-006860-a3b8hyyr	1685	37	undergoing	undergo	VBG
cord-006860-a3b8hyyr	1685	38	CPB	CPB	NNP
cord-006860-a3b8hyyr	1685	39	.	.	.
cord-006860-a3b8hyyr	1686	1	In	in	IN
cord-006860-a3b8hyyr	1686	2	this	this	DT
cord-006860-a3b8hyyr	1686	3	regard	regard	NN
cord-006860-a3b8hyyr	1686	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	1686	5	investigated	investigate	VBD
cord-006860-a3b8hyyr	1686	6	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1686	7	parameters	parameter	NNS
cord-006860-a3b8hyyr	1686	8	like	like	IN
cord-006860-a3b8hyyr	1686	9	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1686	10	,	,	,
cord-006860-a3b8hyyr	1686	11	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	1686	12	,	,	,
cord-006860-a3b8hyyr	1686	13	pmthrombin	pmthrombin	NN
cord-006860-a3b8hyyr	1686	14	-	-	HYPH
cord-006860-a3b8hyyr	1686	15	fragments	fragment	NNS
cord-006860-a3b8hyyr	1686	16	Fl+2	Fl+2	NNS
cord-006860-a3b8hyyr	1686	17	,	,	,
cord-006860-a3b8hyyr	1686	18	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1686	19	-	-	HYPH
cord-006860-a3b8hyyr	1686	20	anthhmmhin	anthhmmhin	NNP
cord-006860-a3b8hyyr	1686	21	complex	complex	NN
cord-006860-a3b8hyyr	1686	22	,	,	,
cord-006860-a3b8hyyr	1686	23	tissue	tissue	NN
cord-006860-a3b8hyyr	1686	24	-	-	HYPH
cord-006860-a3b8hyyr	1686	25	factor	factor	NN
cord-006860-a3b8hyyr	1686	26	,	,	,
cord-006860-a3b8hyyr	1686	27	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1686	28	-	-	HYPH
cord-006860-a3b8hyyr	1686	29	monomeres	monomere	NNS
cord-006860-a3b8hyyr	1686	30	and	and	CC
cord-006860-a3b8hyyr	1686	31	parameters	parameter	NNS
cord-006860-a3b8hyyr	1686	32	of	of	IN
cord-006860-a3b8hyyr	1686	33	the	the	DT
cord-006860-a3b8hyyr	1686	34	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1686	35	system	system	NN
cord-006860-a3b8hyyr	1686	36	like	like	IN
cord-006860-a3b8hyyr	1686	37	tissue	tissue	NN
cord-006860-a3b8hyyr	1686	38	-	-	HYPH
cord-006860-a3b8hyyr	1686	39	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	1686	40	-	-	HYPH
cord-006860-a3b8hyyr	1686	41	activator	activator	NN
cord-006860-a3b8hyyr	1686	42	,	,	,
cord-006860-a3b8hyyr	1686	43	plasminantiplasmin	plasminantiplasmin	NN
cord-006860-a3b8hyyr	1686	44	-	-	HYPH
cord-006860-a3b8hyyr	1686	45	complex	complex	JJ
cord-006860-a3b8hyyr	1686	46	,	,	,
cord-006860-a3b8hyyr	1686	47	d	d	NN
cord-006860-a3b8hyyr	1686	48	-	-	:
cord-006860-a3b8hyyr	1686	49	dimers	dimer	NNS
cord-006860-a3b8hyyr	1686	50	and	and	CC
cord-006860-a3b8hyyr	1686	51	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	1686	52	-	-	HYPH
cord-006860-a3b8hyyr	1686	53	activator	activator	NN
cord-006860-a3b8hyyr	1686	54	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	1686	55	before	before	RB
cord-006860-a3b8hyyr	1686	56	,	,	,
cord-006860-a3b8hyyr	1686	57	during	during	IN
cord-006860-a3b8hyyr	1686	58	and	and	CC
cord-006860-a3b8hyyr	1686	59	after	after	IN
cord-006860-a3b8hyyr	1686	60	CPB	CPB	NNP
cord-006860-a3b8hyyr	1686	61	.	.	.
cord-006860-a3b8hyyr	1687	1	The	the	DT
cord-006860-a3b8hyyr	1687	2	activation	activation	NN
cord-006860-a3b8hyyr	1687	3	of	of	IN
cord-006860-a3b8hyyr	1687	4	the	the	DT
cord-006860-a3b8hyyr	1687	5	complement	complement	JJ
cord-006860-a3b8hyyr	1687	6	cascade	cascade	NN
cord-006860-a3b8hyyr	1687	7	was	be	VBD
cord-006860-a3b8hyyr	1687	8	followed	follow	VBN
cord-006860-a3b8hyyr	1687	9	by	by	IN
cord-006860-a3b8hyyr	1687	10	measuring	measure	VBG
cord-006860-a3b8hyyr	1687	11	the	the	DT
cord-006860-a3b8hyyr	1687	12	concentration	concentration	NN
cord-006860-a3b8hyyr	1687	13	of	of	IN
cord-006860-a3b8hyyr	1687	14	C5a	C5a	NNS
cord-006860-a3b8hyyr	1687	15	,	,	,
cord-006860-a3b8hyyr	1687	16	C4	C4	NNP
cord-006860-a3b8hyyr	1687	17	and	and	CC
cord-006860-a3b8hyyr	1687	18	C3c	C3c	NNP
cord-006860-a3b8hyyr	1687	19	.	.	.
cord-006860-a3b8hyyr	1688	1	The	the	DT
cord-006860-a3b8hyyr	1688	2	results	result	NNS
cord-006860-a3b8hyyr	1688	3	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	1688	4	distinct	distinct	JJ
cord-006860-a3b8hyyr	1688	5	alterations	alteration	NNS
cord-006860-a3b8hyyr	1688	6	in	in	IN
cord-006860-a3b8hyyr	1688	7	above	above	RB
cord-006860-a3b8hyyr	1688	8	mentioned	mention	VBN
cord-006860-a3b8hyyr	1688	9	parameters	parameter	NNS
cord-006860-a3b8hyyr	1688	10	.	.	.
cord-006860-a3b8hyyr	1689	1	In	in	IN
cord-006860-a3b8hyyr	1689	2	spite	spite	NN
cord-006860-a3b8hyyr	1689	3	of	of	IN
cord-006860-a3b8hyyr	1689	4	a	a	DT
cord-006860-a3b8hyyr	1689	5	high	high	JJ
cord-006860-a3b8hyyr	1689	6	dose	dose	NN
cord-006860-a3b8hyyr	1689	7	hepariulzation	hepariulzation	NN
cord-006860-a3b8hyyr	1689	8	(	(	-LRB-
cord-006860-a3b8hyyr	1689	9	ACT>450s	act>450s	NN
cord-006860-a3b8hyyr	1689	10	)	)	-RRB-
cord-006860-a3b8hyyr	1689	11	combined	combine	VBN
cord-006860-a3b8hyyr	1689	12	with	with	IN
cord-006860-a3b8hyyr	1689	13	an	an	DT
cord-006860-a3b8hyyr	1689	14	antifibrinolytic	antifibrinolytic	JJ
cord-006860-a3b8hyyr	1689	15	tw	tw	NNP
cord-006860-a3b8hyyr	1689	16	,	,	,
cord-006860-a3b8hyyr	1689	17	atment	atment	NNP
cord-006860-a3b8hyyr	1689	18	an	an	DT
cord-006860-a3b8hyyr	1689	19	activation	activation	NN
cord-006860-a3b8hyyr	1689	20	of	of	IN
cord-006860-a3b8hyyr	1689	21	the	the	DT
cord-006860-a3b8hyyr	1689	22	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1689	23	system	system	NN
cord-006860-a3b8hyyr	1689	24	was	be	VBD
cord-006860-a3b8hyyr	1689	25	observed	observe	VBN
cord-006860-a3b8hyyr	1689	26	immediately	immediately	RB
cord-006860-a3b8hyyr	1689	27	after	after	IN
cord-006860-a3b8hyyr	1689	28	the	the	DT
cord-006860-a3b8hyyr	1689	29	onset	onset	NN
cord-006860-a3b8hyyr	1689	30	of	of	IN
cord-006860-a3b8hyyr	1689	31	CPB	CPB	NNP
cord-006860-a3b8hyyr	1689	32	followed	follow	VBD
cord-006860-a3b8hyyr	1689	33	by	by	IN
cord-006860-a3b8hyyr	1689	34	an	an	DT
cord-006860-a3b8hyyr	1689	35	activation	activation	NN
cord-006860-a3b8hyyr	1689	36	of	of	IN
cord-006860-a3b8hyyr	1689	37	the	the	DT
cord-006860-a3b8hyyr	1689	38	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1689	39	system	system	NN
cord-006860-a3b8hyyr	1689	40	.	.	.
cord-006860-a3b8hyyr	1690	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	1690	2	further	further	JJ
cord-006860-a3b8hyyr	1690	3	efforts	effort	NNS
cord-006860-a3b8hyyr	1690	4	should	should	MD
cord-006860-a3b8hyyr	1690	5	be	be	VB
cord-006860-a3b8hyyr	1690	6	done	do	VBN
cord-006860-a3b8hyyr	1690	7	to	to	TO
cord-006860-a3b8hyyr	1690	8	develop	develop	VB
cord-006860-a3b8hyyr	1690	9	new	new	JJ
cord-006860-a3b8hyyr	1690	10	anticoagulatory	anticoagulatory	NN
cord-006860-a3b8hyyr	1690	11	regiments	regiment	NNS
cord-006860-a3b8hyyr	1690	12	and	and	CC
cord-006860-a3b8hyyr	1690	13	improve	improve	VB
cord-006860-a3b8hyyr	1690	14	the	the	DT
cord-006860-a3b8hyyr	1690	15	biocompatibility	biocompatibility	NN
cord-006860-a3b8hyyr	1690	16	of	of	IN
cord-006860-a3b8hyyr	1690	17	materials	material	NNS
cord-006860-a3b8hyyr	1690	18	used	use	VBN
cord-006860-a3b8hyyr	1690	19	for	for	IN
cord-006860-a3b8hyyr	1690	20	CPB	CPB	NNP
cord-006860-a3b8hyyr	1690	21	.	.	.
cord-006860-a3b8hyyr	1691	1	During	during	IN
cord-006860-a3b8hyyr	1691	2	cardiopulmonary	cardiopulmonary	JJ
cord-006860-a3b8hyyr	1691	3	bypass	bypass	NN
cord-006860-a3b8hyyr	1691	4	blood	blood	NN
cord-006860-a3b8hyyr	1691	5	is	be	VBZ
cord-006860-a3b8hyyr	1691	6	exposed	expose	VBN
cord-006860-a3b8hyyr	1691	7	to	to	IN
cord-006860-a3b8hyyr	1691	8	nonphysiologic	nonphysiologic	JJ
cord-006860-a3b8hyyr	1691	9	conditions	condition	NNS
cord-006860-a3b8hyyr	1691	10	.	.	.
cord-006860-a3b8hyyr	1692	1	The	the	DT
cord-006860-a3b8hyyr	1692	2	contact	contact	NN
cord-006860-a3b8hyyr	1692	3	with	with	IN
cord-006860-a3b8hyyr	1692	4	artificial	artificial	JJ
cord-006860-a3b8hyyr	1692	5	surfaces	surface	NNS
cord-006860-a3b8hyyr	1692	6	and	and	CC
cord-006860-a3b8hyyr	1692	7	mechanical	mechanical	JJ
cord-006860-a3b8hyyr	1692	8	stress	stress	NN
cord-006860-a3b8hyyr	1692	9	result	result	NN
cord-006860-a3b8hyyr	1692	10	in	in	IN
cord-006860-a3b8hyyr	1692	11	a	a	DT
cord-006860-a3b8hyyr	1692	12	periopemtive	periopemtive	JJ
cord-006860-a3b8hyyr	1692	13	response	response	NN
cord-006860-a3b8hyyr	1692	14	which	which	WDT
cord-006860-a3b8hyyr	1692	15	includes	include	VBZ
cord-006860-a3b8hyyr	1692	16	activation	activation	NN
cord-006860-a3b8hyyr	1692	17	of	of	IN
cord-006860-a3b8hyyr	1692	18	the	the	DT
cord-006860-a3b8hyyr	1692	19	complement	complement	NN
cord-006860-a3b8hyyr	1692	20	,	,	,
cord-006860-a3b8hyyr	1692	21	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1692	22	,	,	,
cord-006860-a3b8hyyr	1692	23	fibrinolytic	fibrinolytic	NNP
cord-006860-a3b8hyyr	1692	24	and	and	CC
cord-006860-a3b8hyyr	1692	25	kallikrein	kallikrein	NNP
cord-006860-a3b8hyyr	1692	26	system	system	NN
cord-006860-a3b8hyyr	1692	27	,	,	,
cord-006860-a3b8hyyr	1692	28	activation	activation	NN
cord-006860-a3b8hyyr	1692	29	of	of	IN
cord-006860-a3b8hyyr	1692	30	nentrophils	nentrophil	NNS
cord-006860-a3b8hyyr	1692	31	with	with	IN
cord-006860-a3b8hyyr	1692	32	degranulation	degranulation	NN
cord-006860-a3b8hyyr	1692	33	and	and	CC
cord-006860-a3b8hyyr	1692	34	pmtease	pmtease	NNP
cord-006860-a3b8hyyr	1692	35	enzyme	enzyme	NN
cord-006860-a3b8hyyr	1692	36	release	release	NN
cord-006860-a3b8hyyr	1692	37	,	,	,
cord-006860-a3b8hyyr	1692	38	oxygen	oxygen	NN
cord-006860-a3b8hyyr	1692	39	radical	radical	JJ
cord-006860-a3b8hyyr	1692	40	production	production	NN
cord-006860-a3b8hyyr	1692	41	and	and	CC
cord-006860-a3b8hyyr	1692	42	the	the	DT
cord-006860-a3b8hyyr	1692	43	synthesis	synthesis	NN
cord-006860-a3b8hyyr	1692	44	of	of	IN
cord-006860-a3b8hyyr	1692	45	various	various	JJ
cord-006860-a3b8hyyr	1692	46	proinflammatory	proinflammatory	JJ
cord-006860-a3b8hyyr	1692	47	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	1692	48	.	.	.
cord-006860-a3b8hyyr	1693	1	This	this	DT
cord-006860-a3b8hyyr	1693	2	so	so	RB
cord-006860-a3b8hyyr	1693	3	-	-	HYPH
cord-006860-a3b8hyyr	1693	4	called	call	VBN
cord-006860-a3b8hyyr	1693	5	"	"	``
cord-006860-a3b8hyyr	1693	6	pest	pest	NN
cord-006860-a3b8hyyr	1693	7	-	-	HYPH
cord-006860-a3b8hyyr	1693	8	pump	pump	NN
cord-006860-a3b8hyyr	1693	9	intlammatory	intlammatory	NNP
cord-006860-a3b8hyyr	1693	10	response	response	NN
cord-006860-a3b8hyyr	1693	11	"	"	''
cord-006860-a3b8hyyr	1693	12	has	have	VBZ
cord-006860-a3b8hyyr	1693	13	been	be	VBN
cord-006860-a3b8hyyr	1693	14	linked	link	VBN
cord-006860-a3b8hyyr	1693	15	to	to	IN
cord-006860-a3b8hyyr	1693	16	respiratory	respiratory	JJ
cord-006860-a3b8hyyr	1693	17	distress	distress	NN
cord-006860-a3b8hyyr	1693	18	syndrome	syndrome	NN
cord-006860-a3b8hyyr	1693	19	,	,	,
cord-006860-a3b8hyyr	1693	20	renal	renal	JJ
cord-006860-a3b8hyyr	1693	21	failure	failure	NN
cord-006860-a3b8hyyr	1693	22	and	and	CC
cord-006860-a3b8hyyr	1693	23	neurologic	neurologic	JJ
cord-006860-a3b8hyyr	1693	24	injmy	injmy	NNP
cord-006860-a3b8hyyr	1693	25	.	.	.
cord-006860-a3b8hyyr	1694	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	1694	2	goal	goal	NN
cord-006860-a3b8hyyr	1694	3	was	be	VBD
cord-006860-a3b8hyyr	1694	4	to	to	TO
cord-006860-a3b8hyyr	1694	5	investigate	investigate	VB
cord-006860-a3b8hyyr	1694	6	the	the	DT
cord-006860-a3b8hyyr	1694	7	time	time	NN
cord-006860-a3b8hyyr	1694	8	course	course	NN
cord-006860-a3b8hyyr	1694	9	of	of	IN
cord-006860-a3b8hyyr	1694	10	eytokine	eytokine	JJ
cord-006860-a3b8hyyr	1694	11	levels	level	NNS
cord-006860-a3b8hyyr	1694	12	and	and	CC
cord-006860-a3b8hyyr	1694	13	the	the	DT
cord-006860-a3b8hyyr	1694	14	activation	activation	NN
cord-006860-a3b8hyyr	1694	15	of	of	IN
cord-006860-a3b8hyyr	1694	16	leukozytes	leukozyte	NNS
cord-006860-a3b8hyyr	1694	17	and	and	CC
cord-006860-a3b8hyyr	1694	18	platelets	platelet	NNS
cord-006860-a3b8hyyr	1694	19	and	and	CC
cord-006860-a3b8hyyr	1694	20	to	to	TO
cord-006860-a3b8hyyr	1694	21	quantitate	quantitate	VB
cord-006860-a3b8hyyr	1694	22	leucocyte	leucocyte	NNP
cord-006860-a3b8hyyr	1694	23	subpepulatioas	subpepulatioas	NNP
cord-006860-a3b8hyyr	1694	24	in	in	IN
cord-006860-a3b8hyyr	1694	25	20	20	CD
cord-006860-a3b8hyyr	1694	26	patients	patient	NNS
cord-006860-a3b8hyyr	1694	27	undergoing	undergo	VBG
cord-006860-a3b8hyyr	1694	28	CPB	CPB	NNP
cord-006860-a3b8hyyr	1694	29	.	.	.
cord-006860-a3b8hyyr	1695	1	At	at	IN
cord-006860-a3b8hyyr	1695	2	different	different	JJ
cord-006860-a3b8hyyr	1695	3	time	time	NN
cord-006860-a3b8hyyr	1695	4	points	point	NNS
cord-006860-a3b8hyyr	1695	5	,	,	,
cord-006860-a3b8hyyr	1695	6	pre	pre	JJ
cord-006860-a3b8hyyr	1695	7	,	,	,
cord-006860-a3b8hyyr	1695	8	during	during	IN
cord-006860-a3b8hyyr	1695	9	and	and	CC
cord-006860-a3b8hyyr	1695	10	pest	pest	NN
cord-006860-a3b8hyyr	1695	11	CPB	CPB	NNP
cord-006860-a3b8hyyr	1695	12	,	,	,
cord-006860-a3b8hyyr	1695	13	we	-PRON-	PRP
cord-006860-a3b8hyyr	1695	14	determined	determine	VBD
cord-006860-a3b8hyyr	1695	15	the	the	DT
cord-006860-a3b8hyyr	1695	16	levels	level	NNS
cord-006860-a3b8hyyr	1695	17	of	of	IN
cord-006860-a3b8hyyr	1695	18	interleukin	interleukin	NN
cord-006860-a3b8hyyr	1695	19	(	(	-LRB-
cord-006860-a3b8hyyr	1695	20	IL	IL	NNP
cord-006860-a3b8hyyr	1695	21	)	)	-RRB-
cord-006860-a3b8hyyr	1695	22	113	113	CD
cord-006860-a3b8hyyr	1695	23	,	,	,
cord-006860-a3b8hyyr	1695	24	IL-2	IL-2	NNP
cord-006860-a3b8hyyr	1695	25	,	,	,
cord-006860-a3b8hyyr	1695	26	IL-4	IL-4	NNP
cord-006860-a3b8hyyr	1695	27	,	,	,
cord-006860-a3b8hyyr	1695	28	IL-6	IL-6	NNP
cord-006860-a3b8hyyr	1695	29	,	,	,
cord-006860-a3b8hyyr	1695	30	IL-8	IL-8	NNP
cord-006860-a3b8hyyr	1695	31	,	,	,
cord-006860-a3b8hyyr	1695	32	IL-10	IL-10	NNP
cord-006860-a3b8hyyr	1695	33	,	,	,
cord-006860-a3b8hyyr	1695	34	tumor	tumor	NN
cord-006860-a3b8hyyr	1695	35	necrosis	necrosis	NN
cord-006860-a3b8hyyr	1695	36	factor	factor	NN
cord-006860-a3b8hyyr	1696	1	¢z	¢z	NNP
cord-006860-a3b8hyyr	1696	2	(	(	-LRB-
cord-006860-a3b8hyyr	1696	3	TNF	TNF	NNP
cord-006860-a3b8hyyr	1696	4	-	-	HYPH
cord-006860-a3b8hyyr	1696	5	a	a	LS
cord-006860-a3b8hyyr	1696	6	)	)	-RRB-
cord-006860-a3b8hyyr	1696	7	and	and	CC
cord-006860-a3b8hyyr	1696	8	interferon	interferon	NN
cord-006860-a3b8hyyr	1696	9	"	"	``
cord-006860-a3b8hyyr	1696	10	1	1	CD
cord-006860-a3b8hyyr	1696	11	'	'	''
cord-006860-a3b8hyyr	1696	12	(	(	-LRB-
cord-006860-a3b8hyyr	1696	13	IFN'--/	ifn'--/	NN
cord-006860-a3b8hyyr	1696	14	)	)	-RRB-
cord-006860-a3b8hyyr	1697	1	using	use	VBG
cord-006860-a3b8hyyr	1697	2	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	1697	3	-	-	HYPH
cord-006860-a3b8hyyr	1697	4	techulques	techulque	NNS
cord-006860-a3b8hyyr	1697	5	.	.	.
cord-006860-a3b8hyyr	1698	1	Lymphozyte	Lymphozyte	NNP
cord-006860-a3b8hyyr	1698	2	subpepulations	subpepulation	NNS
cord-006860-a3b8hyyr	1698	3	were	be	VBD
cord-006860-a3b8hyyr	1698	4	characterized	characterize	VBN
cord-006860-a3b8hyyr	1698	5	by	by	IN
cord-006860-a3b8hyyr	1698	6	flow	flow	NN
cord-006860-a3b8hyyr	1698	7	cytometry	cytometry	NN
cord-006860-a3b8hyyr	1698	8	and	and	CC
cord-006860-a3b8hyyr	1698	9	specific	specific	JJ
cord-006860-a3b8hyyr	1698	10	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	1698	11	antibodies	antibody	NNS
cord-006860-a3b8hyyr	1698	12	against	against	IN
cord-006860-a3b8hyyr	1698	13	CD3	CD3	NNP
cord-006860-a3b8hyyr	1698	14	(	(	-LRB-
cord-006860-a3b8hyyr	1698	15	pan	pan	NNP
cord-006860-a3b8hyyr	1698	16	T	T	NNP
cord-006860-a3b8hyyr	1698	17	-	-	HYPH
cord-006860-a3b8hyyr	1698	18	cell	cell	NN
cord-006860-a3b8hyyr	1698	19	marker	marker	NN
cord-006860-a3b8hyyr	1698	20	)	)	-RRB-
cord-006860-a3b8hyyr	1698	21	,	,	,
cord-006860-a3b8hyyr	1698	22	CD4	CD4	NNP
cord-006860-a3b8hyyr	1698	23	(	(	-LRB-
cord-006860-a3b8hyyr	1698	24	surface	surface	NN
cord-006860-a3b8hyyr	1698	25	antigen	antigen	NN
cord-006860-a3b8hyyr	1698	26	on	on	IN
cord-006860-a3b8hyyr	1698	27	T	t	NN
cord-006860-a3b8hyyr	1698	28	-	-	HYPH
cord-006860-a3b8hyyr	1698	29	helper	helper	NN
cord-006860-a3b8hyyr	1698	30	cells	cell	NNS
cord-006860-a3b8hyyr	1698	31	)	)	-RRB-
cord-006860-a3b8hyyr	1698	32	,	,	,
cord-006860-a3b8hyyr	1698	33	CD19	CD19	NNP
cord-006860-a3b8hyyr	1698	34	(	(	-LRB-
cord-006860-a3b8hyyr	1698	35	surface	surface	NN
cord-006860-a3b8hyyr	1698	36	antigen	antigen	NN
cord-006860-a3b8hyyr	1698	37	on	on	IN
cord-006860-a3b8hyyr	1698	38	B	b	NN
cord-006860-a3b8hyyr	1698	39	-	-	HYPH
cord-006860-a3b8hyyr	1698	40	cells	cell	NNS
cord-006860-a3b8hyyr	1698	41	)	)	-RRB-
cord-006860-a3b8hyyr	1698	42	,	,	,
cord-006860-a3b8hyyr	1698	43	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	1698	44	were	be	VBD
cord-006860-a3b8hyyr	1698	45	determined	determine	VBN
cord-006860-a3b8hyyr	1698	46	by	by	IN
cord-006860-a3b8hyyr	1698	47	CD14	CD14	NNP
cord-006860-a3b8hyyr	1698	48	and	and	CC
cord-006860-a3b8hyyr	1698	49	platelets	platelet	NNS
cord-006860-a3b8hyyr	1698	50	by	by	IN
cord-006860-a3b8hyyr	1698	51	CD41	CD41	NNP
cord-006860-a3b8hyyr	1698	52	(	(	-LRB-
cord-006860-a3b8hyyr	1698	53	act	act	NN
cord-006860-a3b8hyyr	1698	54	.	.	.
cord-006860-a3b8hyyr	1699	1	GPIlb	GPIlb	NNP
cord-006860-a3b8hyyr	1699	2	/	/	SYM
cord-006860-a3b8hyyr	1699	3	llla	llla	NNP
cord-006860-a3b8hyyr	1699	4	)	)	-RRB-
cord-006860-a3b8hyyr	1699	5	and	and	CC
cord-006860-a3b8hyyr	1699	6	CD42b	CD42b	NNP
cord-006860-a3b8hyyr	1699	7	(	(	-LRB-
cord-006860-a3b8hyyr	1699	8	GP	GP	NNP
cord-006860-a3b8hyyr	1699	9	Ib	Ib	NNP
cord-006860-a3b8hyyr	1699	10	)	)	-RRB-
cord-006860-a3b8hyyr	1699	11	.	.	.
cord-006860-a3b8hyyr	1700	1	Single	single	JJ
cord-006860-a3b8hyyr	1700	2	cell	cell	NN
cord-006860-a3b8hyyr	1700	3	activation	activation	NN
cord-006860-a3b8hyyr	1700	4	was	be	VBD
cord-006860-a3b8hyyr	1700	5	analyzed	analyze	VBN
cord-006860-a3b8hyyr	1700	6	using	use	VBG
cord-006860-a3b8hyyr	1700	7	markers	marker	NNS
cord-006860-a3b8hyyr	1700	8	against	against	IN
cord-006860-a3b8hyyr	1700	9	CD25	CD25	NNP
cord-006860-a3b8hyyr	1700	10	(	(	-LRB-
cord-006860-a3b8hyyr	1700	11	IL-2	IL-2	NNP
cord-006860-a3b8hyyr	1700	12	receptor	receptor	NN
cord-006860-a3b8hyyr	1700	13	)	)	-RRB-
cord-006860-a3b8hyyr	1700	14	,	,	.
cord-006860-a3b8hyyr	1701	1	CD126	CD126	NNP
cord-006860-a3b8hyyr	1701	2	(	(	-LRB-
cord-006860-a3b8hyyr	1701	3	IL-6	IL-6	NNP
cord-006860-a3b8hyyr	1701	4	receptor	receptor	NN
cord-006860-a3b8hyyr	1701	5	)	)	-RRB-
cord-006860-a3b8hyyr	1701	6	,	,	,
cord-006860-a3b8hyyr	1701	7	HLA	HLA	NNP
cord-006860-a3b8hyyr	1701	8	-	-	HYPH
cord-006860-a3b8hyyr	1701	9	DR	DR	NNP
cord-006860-a3b8hyyr	1701	10	(	(	-LRB-
cord-006860-a3b8hyyr	1701	11	MHC	MHC	NNP
cord-006860-a3b8hyyr	1701	12	class	class	NN
cord-006860-a3b8hyyr	1701	13	II	II	NNP
cord-006860-a3b8hyyr	1701	14	)	)	-RRB-
cord-006860-a3b8hyyr	1702	1	,	,	,
cord-006860-a3b8hyyr	1702	2	CD71	CD71	NNP
cord-006860-a3b8hyyr	1702	3	(	(	-LRB-
cord-006860-a3b8hyyr	1702	4	transferrin	transferrin	NN
cord-006860-a3b8hyyr	1702	5	receptor	receptor	NN
cord-006860-a3b8hyyr	1702	6	)	)	-RRB-
cord-006860-a3b8hyyr	1702	7	and	and	CC
cord-006860-a3b8hyyr	1702	8	CD69	CD69	NNP
cord-006860-a3b8hyyr	1702	9	(	(	-LRB-
cord-006860-a3b8hyyr	1702	10	activation	activation	NN
cord-006860-a3b8hyyr	1702	11	inducer	inducer	NN
cord-006860-a3b8hyyr	1702	12	molecule	molecule	NN
cord-006860-a3b8hyyr	1702	13	)	)	-RRB-
cord-006860-a3b8hyyr	1702	14	,	,	,
cord-006860-a3b8hyyr	1702	15	platelet	platelet	NN
cord-006860-a3b8hyyr	1702	16	activation	activation	NN
cord-006860-a3b8hyyr	1702	17	was	be	VBD
cord-006860-a3b8hyyr	1702	18	monitored	monitor	VBN
cord-006860-a3b8hyyr	1702	19	with	with	IN
cord-006860-a3b8hyyr	1702	20	an	an	DT
cord-006860-a3b8hyyr	1702	21	antibody	antibody	NN
cord-006860-a3b8hyyr	1702	22	against	against	IN
cord-006860-a3b8hyyr	1702	23	CD62	CD62	NNP
cord-006860-a3b8hyyr	1702	24	(	(	-LRB-
cord-006860-a3b8hyyr	1702	25	GMP-140	GMP-140	NNP
cord-006860-a3b8hyyr	1702	26	)	)	-RRB-
cord-006860-a3b8hyyr	1702	27	.	.	.
cord-006860-a3b8hyyr	1703	1	Preliminary	preliminary	JJ
cord-006860-a3b8hyyr	1703	2	results	result	NNS
cord-006860-a3b8hyyr	1703	3	revealed	reveal	VBD
cord-006860-a3b8hyyr	1703	4	distinct	distinct	JJ
cord-006860-a3b8hyyr	1703	5	increases	increase	NNS
cord-006860-a3b8hyyr	1703	6	in	in	IN
cord-006860-a3b8hyyr	1703	7	R,-6	R,-6	NNP
cord-006860-a3b8hyyr	1703	8	,	,	,
cord-006860-a3b8hyyr	1703	9	IL-8	IL-8	NNP
cord-006860-a3b8hyyr	1703	10	,	,	,
cord-006860-a3b8hyyr	1703	11	and	and	CC
cord-006860-a3b8hyyr	1703	12	IL	IL	NNP
cord-006860-a3b8hyyr	1703	13	-	-	HYPH
cord-006860-a3b8hyyr	1703	14	IO	IO	NNP
cord-006860-a3b8hyyr	1703	15	following	follow	VBG
cord-006860-a3b8hyyr	1703	16	CPB	CPB	NNP
cord-006860-a3b8hyyr	1703	17	whereas	whereas	IN
cord-006860-a3b8hyyr	1703	18	TNF	TNF	NNP
cord-006860-a3b8hyyr	1703	19	-	-	:
cord-006860-a3b8hyyr	1703	20	a	a	NN
cord-006860-a3b8hyyr	1704	1	and	and	CC
cord-006860-a3b8hyyr	1704	2	IFN--/levels	ifn--/level	NNS
cord-006860-a3b8hyyr	1704	3	were	be	VBD
cord-006860-a3b8hyyr	1704	4	not	not	RB
cord-006860-a3b8hyyr	1704	5	significantly	significantly	RB
cord-006860-a3b8hyyr	1704	6	influenced	influence	VBN
cord-006860-a3b8hyyr	1704	7	.	.	.
cord-006860-a3b8hyyr	1705	1	Fttnhermore	Fttnhermore	NNP
cord-006860-a3b8hyyr	1705	2	,	,	,
cord-006860-a3b8hyyr	1705	3	activation	activation	NN
cord-006860-a3b8hyyr	1705	4	of	of	IN
cord-006860-a3b8hyyr	1705	5	particular	particular	JJ
cord-006860-a3b8hyyr	1705	6	cell	cell	NN
cord-006860-a3b8hyyr	1705	7	populations	population	NNS
cord-006860-a3b8hyyr	1705	8	was	be	VBD
cord-006860-a3b8hyyr	1705	9	observed	observe	VBN
cord-006860-a3b8hyyr	1705	10	.	.	.
cord-006860-a3b8hyyr	1706	1	Finally	finally	RB
cord-006860-a3b8hyyr	1706	2	,	,	,
cord-006860-a3b8hyyr	1706	3	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1706	4	investigations	investigation	NNS
cord-006860-a3b8hyyr	1706	5	should	should	MD
cord-006860-a3b8hyyr	1706	6	contribute	contribute	VB
cord-006860-a3b8hyyr	1706	7	to	to	IN
cord-006860-a3b8hyyr	1706	8	a	a	DT
cord-006860-a3b8hyyr	1706	9	better	well	JJR
cord-006860-a3b8hyyr	1706	10	understanding	understanding	NN
cord-006860-a3b8hyyr	1706	11	of	of	IN
cord-006860-a3b8hyyr	1706	12	the	the	DT
cord-006860-a3b8hyyr	1706	13	complex	complex	JJ
cord-006860-a3b8hyyr	1706	14	humeral	humeral	JJ
cord-006860-a3b8hyyr	1706	15	and	and	CC
cord-006860-a3b8hyyr	1706	16	cellular	cellular	JJ
cord-006860-a3b8hyyr	1706	17	respenses	respense	NNS
cord-006860-a3b8hyyr	1706	18	induced	induce	VBN
cord-006860-a3b8hyyr	1706	19	by	by	IN
cord-006860-a3b8hyyr	1706	20	CPB	CPB	NNP
cord-006860-a3b8hyyr	1706	21	and	and	CC
cord-006860-a3b8hyyr	1706	22	thus	thus	RB
cord-006860-a3b8hyyr	1706	23	might	may	MD
cord-006860-a3b8hyyr	1706	24	help	help	VB
cord-006860-a3b8hyyr	1706	25	to	to	TO
cord-006860-a3b8hyyr	1706	26	develop	develop	VB
cord-006860-a3b8hyyr	1706	27	new	new	JJ
cord-006860-a3b8hyyr	1706	28	strategies	strategy	NNS
cord-006860-a3b8hyyr	1706	29	to	to	TO
cord-006860-a3b8hyyr	1706	30	circumvent	circumvent	VB
cord-006860-a3b8hyyr	1706	31	the	the	DT
cord-006860-a3b8hyyr	1706	32	negative	negative	JJ
cord-006860-a3b8hyyr	1706	33	impacts	impact	NNS
cord-006860-a3b8hyyr	1706	34	of	of	IN
cord-006860-a3b8hyyr	1706	35	CPB	CPB	NNP
cord-006860-a3b8hyyr	1706	36	.	.	.
cord-006860-a3b8hyyr	1707	1	Optimal	optimal	JJ
cord-006860-a3b8hyyr	1707	2	adjustment	adjustment	NN
cord-006860-a3b8hyyr	1707	3	of	of	IN
cord-006860-a3b8hyyr	1707	4	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	1707	5	in	in	IN
cord-006860-a3b8hyyr	1707	6	machine	machine	NN
cord-006860-a3b8hyyr	1707	7	plasmapheresis	plasmapheresis	NN
cord-006860-a3b8hyyr	1707	8	is	be	VBZ
cord-006860-a3b8hyyr	1707	9	important	important	JJ
cord-006860-a3b8hyyr	1707	10	for	for	IN
cord-006860-a3b8hyyr	1707	11	the	the	DT
cord-006860-a3b8hyyr	1707	12	quality	quality	NN
cord-006860-a3b8hyyr	1707	13	of	of	IN
cord-006860-a3b8hyyr	1707	14	the	the	DT
cord-006860-a3b8hyyr	1707	15	prepared	prepared	JJ
cord-006860-a3b8hyyr	1707	16	fresh	fresh	JJ
cord-006860-a3b8hyyr	1707	17	frozen	frozen	JJ
cord-006860-a3b8hyyr	1707	18	plasma	plasma	NN
cord-006860-a3b8hyyr	1707	19	(	(	-LRB-
cord-006860-a3b8hyyr	1707	20	FFP	FFP	NNP
cord-006860-a3b8hyyr	1707	21	)	)	-RRB-
cord-006860-a3b8hyyr	1707	22	as	as	RB
cord-006860-a3b8hyyr	1707	23	well	well	RB
cord-006860-a3b8hyyr	1707	24	as	as	IN
cord-006860-a3b8hyyr	1707	25	for	for	IN
cord-006860-a3b8hyyr	1707	26	the	the	DT
cord-006860-a3b8hyyr	1707	27	safety	safety	NN
cord-006860-a3b8hyyr	1707	28	of	of	IN
cord-006860-a3b8hyyr	1707	29	the	the	DT
cord-006860-a3b8hyyr	1707	30	donation	donation	NN
cord-006860-a3b8hyyr	1707	31	.	.	.
cord-006860-a3b8hyyr	1708	1	In	in	IN
cord-006860-a3b8hyyr	1708	2	the	the	DT
cord-006860-a3b8hyyr	1708	3	present	present	JJ
cord-006860-a3b8hyyr	1708	4	study	study	NN
cord-006860-a3b8hyyr	1708	5	the	the	DT
cord-006860-a3b8hyyr	1708	6	suitability	suitability	NN
cord-006860-a3b8hyyr	1708	7	of	of	IN
cord-006860-a3b8hyyr	1708	8	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	1708	9	fragment	fragment	NN
cord-006860-a3b8hyyr	1708	10	(	(	-LRB-
cord-006860-a3b8hyyr	1708	11	Ft+2	Ft+2	NNP
cord-006860-a3b8hyyr	1708	12	)	)	-RRB-
cord-006860-a3b8hyyr	1708	13	in	in	IN
cord-006860-a3b8hyyr	1708	14	the	the	DT
cord-006860-a3b8hyyr	1708	15	assessment	assessment	NN
cord-006860-a3b8hyyr	1708	16	of	of	IN
cord-006860-a3b8hyyr	1708	17	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	1708	18	during	during	IN
cord-006860-a3b8hyyr	1708	19	plasmapheresis	plasmapheresis	NN
cord-006860-a3b8hyyr	1708	20	was	be	VBD
cord-006860-a3b8hyyr	1708	21	investigated	investigate	VBN
cord-006860-a3b8hyyr	1708	22	.	.	.
cord-006860-a3b8hyyr	1709	1	Matarlal	Matarlal	NNP
cord-006860-a3b8hyyr	1709	2	and	and	CC
cord-006860-a3b8hyyr	1709	3	Methods	Methods	NNPS
cord-006860-a3b8hyyr	1709	4	:	:	:
cord-006860-a3b8hyyr	1709	5	75	75	CD
cord-006860-a3b8hyyr	1709	6	plasmapheresis	plasmapheresis	NN
cord-006860-a3b8hyyr	1709	7	procedures	procedure	NNS
cord-006860-a3b8hyyr	1709	8	were	be	VBD
cord-006860-a3b8hyyr	1709	9	performed	perform	VBN
cord-006860-a3b8hyyr	1709	10	on	on	IN
cord-006860-a3b8hyyr	1709	11	25	25	CD
cord-006860-a3b8hyyr	1709	12	donors	donor	NNS
cord-006860-a3b8hyyr	1709	13	(	(	-LRB-
cord-006860-a3b8hyyr	1709	14	10	10	CD
cord-006860-a3b8hyyr	1709	15	~	~	CD
cord-006860-a3b8hyyr	1709	16	,	,	,
cord-006860-a3b8hyyr	1709	17	15o	15o	NNS
cord-006860-a3b8hyyr	1709	18	"	"	''
cord-006860-a3b8hyyr	1709	19	)	)	-RRB-
cord-006860-a3b8hyyr	1709	20	using	use	VBG
cord-006860-a3b8hyyr	1709	21	3	3	CD
cord-006860-a3b8hyyr	1709	22	different	different	JJ
cord-006860-a3b8hyyr	1709	23	plasmapheresis	plasmapheresis	NN
cord-006860-a3b8hyyr	1709	24	machines	machine	NNS
cord-006860-a3b8hyyr	1709	25	(	(	-LRB-
cord-006860-a3b8hyyr	1709	26	A	a	DT
cord-006860-a3b8hyyr	1709	27	200	200	CD
cord-006860-a3b8hyyr	1709	28	,	,	,
cord-006860-a3b8hyyr	1709	29	Baxter	Baxter	NNP
cord-006860-a3b8hyyr	1709	30	;	;	:
cord-006860-a3b8hyyr	1709	31	MCS	MCS	NNP
cord-006860-a3b8hyyr	1709	32	3p	3p	CD
cord-006860-a3b8hyyr	1709	33	,	,	,
cord-006860-a3b8hyyr	1709	34	Haemonetics	Haemonetics	NNP
cord-006860-a3b8hyyr	1709	35	;	;	:
cord-006860-a3b8hyyr	1709	36	PPH	PPH	NNP
cord-006860-a3b8hyyr	1709	37	900	900	CD
cord-006860-a3b8hyyr	1709	38	,	,	,
cord-006860-a3b8hyyr	1709	39	Electromedics	Electromedics	NNP
cord-006860-a3b8hyyr	1709	40	/	/	SYM
cord-006860-a3b8hyyr	1709	41	Medtronic	Medtronic	NNP
cord-006860-a3b8hyyr	1709	42	)	)	-RRB-
cord-006860-a3b8hyyr	1709	43	.	.	.
cord-006860-a3b8hyyr	1710	1	Acid	Acid	NNP
cord-006860-a3b8hyyr	1710	2	Citrate	Citrate	NNP
cord-006860-a3b8hyyr	1711	1	Dextrose	dextrose	NN
cord-006860-a3b8hyyr	1712	1	formula	formula	NNP
cord-006860-a3b8hyyr	1712	2	A	A	NNP
cord-006860-a3b8hyyr	1712	3	(	(	-LRB-
cord-006860-a3b8hyyr	1712	4	ACD	ACD	NNP
cord-006860-a3b8hyyr	1712	5	-	-	HYPH
cord-006860-a3b8hyyr	1712	6	A	A	NNP
cord-006860-a3b8hyyr	1712	7	)	)	-RRB-
cord-006860-a3b8hyyr	1712	8	in	in	IN
cord-006860-a3b8hyyr	1712	9	a	a	DT
cord-006860-a3b8hyyr	1712	10	ratio	ratio	NN
cord-006860-a3b8hyyr	1712	11	to	to	IN
cord-006860-a3b8hyyr	1712	12	whole	whole	JJ
cord-006860-a3b8hyyr	1712	13	blood	blood	NN
cord-006860-a3b8hyyr	1712	14	of	of	IN
cord-006860-a3b8hyyr	1712	15	8	8	CD
cord-006860-a3b8hyyr	1712	16	:	:	SYM
cord-006860-a3b8hyyr	1712	17	92	92	CD
cord-006860-a3b8hyyr	1712	18	was	be	VBD
cord-006860-a3b8hyyr	1712	19	used	use	VBN
cord-006860-a3b8hyyr	1712	20	for	for	IN
cord-006860-a3b8hyyr	1712	21	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	1712	22	.	.	.
cord-006860-a3b8hyyr	1713	1	The	the	DT
cord-006860-a3b8hyyr	1713	2	concentration	concentration	NN
cord-006860-a3b8hyyr	1713	3	of	of	IN
cord-006860-a3b8hyyr	1713	4	FI+2	FI+2	NNP
cord-006860-a3b8hyyr	1713	5	in	in	IN
cord-006860-a3b8hyyr	1713	6	the	the	DT
cord-006860-a3b8hyyr	1713	7	donor	donor	NN
cord-006860-a3b8hyyr	1713	8	's	's	POS
cord-006860-a3b8hyyr	1713	9	blood	blood	NN
cord-006860-a3b8hyyr	1713	10	was	be	VBD
cord-006860-a3b8hyyr	1713	11	measured	measure	VBN
cord-006860-a3b8hyyr	1713	12	before	before	RB
cord-006860-a3b8hyyr	1713	13	and	and	CC
cord-006860-a3b8hyyr	1713	14	after	after	IN
cord-006860-a3b8hyyr	1713	15	plasmapheresis	plasmapheresis	NN
cord-006860-a3b8hyyr	1713	16	and	and	CC
cord-006860-a3b8hyyr	1713	17	in	in	IN
cord-006860-a3b8hyyr	1713	18	the	the	DT
cord-006860-a3b8hyyr	1713	19	prepared	prepared	JJ
cord-006860-a3b8hyyr	1713	20	FFP	ffp	NN
cord-006860-a3b8hyyr	1713	21	.	.	.
cord-006860-a3b8hyyr	1714	1	The	the	DT
cord-006860-a3b8hyyr	1714	2	actual	actual	JJ
cord-006860-a3b8hyyr	1714	3	ACD	acd	NN
cord-006860-a3b8hyyr	1714	4	-	-	HYPH
cord-006860-a3b8hyyr	1714	5	A	a	NN
cord-006860-a3b8hyyr	1714	6	volume	volume	NN
cord-006860-a3b8hyyr	1714	7	used	use	VBN
cord-006860-a3b8hyyr	1714	8	was	be	VBD
cord-006860-a3b8hyyr	1714	9	also	also	RB
cord-006860-a3b8hyyr	1714	10	registered	register	VBN
cord-006860-a3b8hyyr	1714	11	.	.	.
cord-006860-a3b8hyyr	1715	1	Results	result	NNS
cord-006860-a3b8hyyr	1715	2	:	:	:
cord-006860-a3b8hyyr	1716	1	There	there	EX
cord-006860-a3b8hyyr	1716	2	was	be	VBD
cord-006860-a3b8hyyr	1716	3	a	a	DT
cord-006860-a3b8hyyr	1716	4	significant	significant	JJ
cord-006860-a3b8hyyr	1716	5	rise	rise	NN
cord-006860-a3b8hyyr	1716	6	of	of	IN
cord-006860-a3b8hyyr	1716	7	the	the	DT
cord-006860-a3b8hyyr	1716	8	Ft+2	Ft+2	NNP
cord-006860-a3b8hyyr	1716	9	-concentration	-concentration	NN
cord-006860-a3b8hyyr	1716	10	in	in	IN
cord-006860-a3b8hyyr	1716	11	the	the	DT
cord-006860-a3b8hyyr	1716	12	donors	donor	NNS
cord-006860-a3b8hyyr	1716	13	blood	blood	NN
cord-006860-a3b8hyyr	1716	14	after	after	IN
cord-006860-a3b8hyyr	1716	15	plasmapheresis	plasmapheresis	NN
cord-006860-a3b8hyyr	1716	16	with	with	IN
cord-006860-a3b8hyyr	1716	17	each	each	DT
cord-006860-a3b8hyyr	1716	18	of	of	IN
cord-006860-a3b8hyyr	1716	19	the	the	DT
cord-006860-a3b8hyyr	1716	20	three	three	CD
cord-006860-a3b8hyyr	1716	21	automatons	automaton	NNS
cord-006860-a3b8hyyr	1716	22	:	:	:
cord-006860-a3b8hyyr	1717	1	A	a	DT
cord-006860-a3b8hyyr	1717	2	200:1.32	200:1.32	CD
cord-006860-a3b8hyyr	1718	1	vs	vs	IN
cord-006860-a3b8hyyr	1718	2	1.14	1.14	CD
cord-006860-a3b8hyyr	1718	3	,	,	,
cord-006860-a3b8hyyr	1718	4	p	p	NN
cord-006860-a3b8hyyr	1718	5	<	<	XX
cord-006860-a3b8hyyr	1718	6	0.05	0.05	CD
cord-006860-a3b8hyyr	1718	7	;	;	:
cord-006860-a3b8hyyr	1718	8	MCS	MCS	NNP
cord-006860-a3b8hyyr	1718	9	3p	3p	CD
cord-006860-a3b8hyyr	1718	10	:	:	:
cord-006860-a3b8hyyr	1719	1	1.26	1.26	CD
cord-006860-a3b8hyyr	1719	2	vs	vs	IN
cord-006860-a3b8hyyr	1719	3	0.98	0.98	CD
cord-006860-a3b8hyyr	1719	4	,	,	,
cord-006860-a3b8hyyr	1719	5	p	p	NN
cord-006860-a3b8hyyr	1719	6	<	<	XX
cord-006860-a3b8hyyr	1719	7	0.05	0.05	CD
cord-006860-a3b8hyyr	1719	8	;	;	:
cord-006860-a3b8hyyr	1719	9	PPH	pph	NN
cord-006860-a3b8hyyr	1719	10	900:1.20	900:1.20	CD
cord-006860-a3b8hyyr	1719	11	vs	vs	IN
cord-006860-a3b8hyyr	1719	12	1.05	1.05	CD
cord-006860-a3b8hyyr	1719	13	,	,	,
cord-006860-a3b8hyyr	1719	14	p	p	NN
cord-006860-a3b8hyyr	1719	15	<	<	XX
cord-006860-a3b8hyyr	1719	16	0.05	0.05	CD
cord-006860-a3b8hyyr	1719	17	.	.	.
cord-006860-a3b8hyyr	1720	1	The	the	DT
cord-006860-a3b8hyyr	1720	2	FFP	FFP	NNP
cord-006860-a3b8hyyr	1720	3	prepared	prepare	VBD
cord-006860-a3b8hyyr	1720	4	with	with	IN
cord-006860-a3b8hyyr	1720	5	each	each	DT
cord-006860-a3b8hyyr	1720	6	machine	machine	NN
cord-006860-a3b8hyyr	1720	7	showed	show	VBD
cord-006860-a3b8hyyr	1720	8	the	the	DT
cord-006860-a3b8hyyr	1720	9	following	follow	VBG
cord-006860-a3b8hyyr	1720	10	F~+2concentrations	f~+2concentration	NNS
cord-006860-a3b8hyyr	1720	11	:	:	:
cord-006860-a3b8hyyr	1720	12	0.91±	0.91±	CD
cord-006860-a3b8hyyr	1720	13	0.18	0.18	CD
cord-006860-a3b8hyyr	1720	14	,	,	,
cord-006860-a3b8hyyr	1720	15	1.0:2	1.0:2	NNP
cord-006860-a3b8hyyr	1720	16	±	±	CD
cord-006860-a3b8hyyr	1720	17	0.17	0.17	CD
cord-006860-a3b8hyyr	1720	18	and	and	CC
cord-006860-a3b8hyyr	1720	19	0.93	0.93	CD
cord-006860-a3b8hyyr	1720	20	±	±	CD
cord-006860-a3b8hyyr	1720	21	0.11	0.11	CD
cord-006860-a3b8hyyr	1720	22	respectively	respectively	RB
cord-006860-a3b8hyyr	1720	23	.	.	.
cord-006860-a3b8hyyr	1721	1	The	the	DT
cord-006860-a3b8hyyr	1721	2	difference	difference	NN
cord-006860-a3b8hyyr	1721	3	between	between	IN
cord-006860-a3b8hyyr	1721	4	the	the	DT
cord-006860-a3b8hyyr	1721	5	groups	group	NNS
cord-006860-a3b8hyyr	1721	6	was	be	VBD
cord-006860-a3b8hyyr	1721	7	not	not	RB
cord-006860-a3b8hyyr	1721	8	significant	significant	JJ
cord-006860-a3b8hyyr	1721	9	.	.	.
cord-006860-a3b8hyyr	1722	1	The	the	DT
cord-006860-a3b8hyyr	1722	2	elevation	elevation	NN
cord-006860-a3b8hyyr	1722	3	of	of	IN
cord-006860-a3b8hyyr	1722	4	the	the	DT
cord-006860-a3b8hyyr	1722	5	Ft+2	Ft+2	NNP
cord-006860-a3b8hyyr	1722	6	-concentration	-concentration	NN
cord-006860-a3b8hyyr	1722	7	in	in	IN
cord-006860-a3b8hyyr	1722	8	the	the	DT
cord-006860-a3b8hyyr	1722	9	donor	donor	NN
cord-006860-a3b8hyyr	1722	10	's	's	POS
cord-006860-a3b8hyyr	1722	11	blood	blood	NN
cord-006860-a3b8hyyr	1722	12	showed	show	VBD
cord-006860-a3b8hyyr	1722	13	a	a	DT
cord-006860-a3b8hyyr	1722	14	negative	negative	JJ
cord-006860-a3b8hyyr	1722	15	correlation	correlation	NN
cord-006860-a3b8hyyr	1722	16	with	with	IN
cord-006860-a3b8hyyr	1722	17	the	the	DT
cord-006860-a3b8hyyr	1722	18	volume	volume	NN
cord-006860-a3b8hyyr	1722	19	of	of	IN
cord-006860-a3b8hyyr	1722	20	the	the	DT
cord-006860-a3b8hyyr	1722	21	ACD	ACD	NNP
cord-006860-a3b8hyyr	1722	22	-	-	HYPH
cord-006860-a3b8hyyr	1722	23	A	A	NNP
cord-006860-a3b8hyyr	1722	24	used	use	VBN
cord-006860-a3b8hyyr	1722	25	.	.	.
cord-006860-a3b8hyyr	1723	1	During	during	IN
cord-006860-a3b8hyyr	1723	2	6	6	CD
cord-006860-a3b8hyyr	1723	3	of	of	IN
cord-006860-a3b8hyyr	1723	4	the	the	DT
cord-006860-a3b8hyyr	1723	5	75	75	CD
cord-006860-a3b8hyyr	1723	6	procedures	procedure	NNS
cord-006860-a3b8hyyr	1723	7	technical	technical	JJ
cord-006860-a3b8hyyr	1723	8	problems	problem	NNS
cord-006860-a3b8hyyr	1723	9	occurred	occur	VBD
cord-006860-a3b8hyyr	1723	10	(	(	-LRB-
cord-006860-a3b8hyyr	1723	11	inadequate	inadequate	JJ
cord-006860-a3b8hyyr	1723	12	venous	venous	JJ
cord-006860-a3b8hyyr	1723	13	acces	acces	NN
cord-006860-a3b8hyyr	1723	14	,	,	,
cord-006860-a3b8hyyr	1723	15	occlusion	occlusion	NN
cord-006860-a3b8hyyr	1723	16	of	of	IN
cord-006860-a3b8hyyr	1723	17	the	the	DT
cord-006860-a3b8hyyr	1723	18	citrate	citrate	NN
cord-006860-a3b8hyyr	1723	19	tube	tube	NN
cord-006860-a3b8hyyr	1723	20	,	,	,
cord-006860-a3b8hyyr	1723	21	reduced	reduce	VBN
cord-006860-a3b8hyyr	1723	22	whole	whole	JJ
cord-006860-a3b8hyyr	1723	23	blood	blood	NN
cord-006860-a3b8hyyr	1723	24	flow	flow	NN
cord-006860-a3b8hyyr	1723	25	)	)	-RRB-
cord-006860-a3b8hyyr	1723	26	.	.	.
cord-006860-a3b8hyyr	1724	1	After	after	IN
cord-006860-a3b8hyyr	1724	2	these	these	DT
cord-006860-a3b8hyyr	1724	3	procedures	procedure	NNS
cord-006860-a3b8hyyr	1724	4	there	there	EX
cord-006860-a3b8hyyr	1724	5	was	be	VBD
cord-006860-a3b8hyyr	1724	6	a	a	DT
cord-006860-a3b8hyyr	1724	7	marked	marked	JJ
cord-006860-a3b8hyyr	1724	8	elevation	elevation	NN
cord-006860-a3b8hyyr	1724	9	of	of	IN
cord-006860-a3b8hyyr	1724	10	F~+2	F~+2	NNP
cord-006860-a3b8hyyr	1724	11	in	in	IN
cord-006860-a3b8hyyr	1724	12	the	the	DT
cord-006860-a3b8hyyr	1724	13	donors	donor	NNS
cord-006860-a3b8hyyr	1724	14	blood	blood	NN
cord-006860-a3b8hyyr	1724	15	(	(	-LRB-
cord-006860-a3b8hyyr	1724	16	2.74	2.74	CD
cord-006860-a3b8hyyr	1724	17	±	±	CD
cord-006860-a3b8hyyr	1724	18	0.53	0.53	CD
cord-006860-a3b8hyyr	1724	19	)	)	-RRB-
cord-006860-a3b8hyyr	1724	20	,	,	,
cord-006860-a3b8hyyr	1724	21	accompanied	accompany	VBN
cord-006860-a3b8hyyr	1724	22	by	by	IN
cord-006860-a3b8hyyr	1724	23	an	an	DT
cord-006860-a3b8hyyr	1724	24	elevated	elevated	JJ
cord-006860-a3b8hyyr	1724	25	F~+2	F~+2	NNP
cord-006860-a3b8hyyr	1724	26	-concentration	-concentration	NN
cord-006860-a3b8hyyr	1724	27	in	in	IN
cord-006860-a3b8hyyr	1724	28	the	the	DT
cord-006860-a3b8hyyr	1724	29	prepared	prepared	JJ
cord-006860-a3b8hyyr	1724	30	FFP	FFP	NNP
cord-006860-a3b8hyyr	1724	31	's	's	POS
cord-006860-a3b8hyyr	1724	32	.	.	.
cord-006860-a3b8hyyr	1725	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	1725	2	:	:	:
cord-006860-a3b8hyyr	1726	1	These	these	DT
cord-006860-a3b8hyyr	1726	2	data	datum	NNS
cord-006860-a3b8hyyr	1726	3	show	show	VBP
cord-006860-a3b8hyyr	1726	4	that	that	IN
cord-006860-a3b8hyyr	1726	5	Ft+2	Ft+2	NNP
cord-006860-a3b8hyyr	1726	6	is	be	VBZ
cord-006860-a3b8hyyr	1726	7	a	a	DT
cord-006860-a3b8hyyr	1726	8	suitable	suitable	JJ
cord-006860-a3b8hyyr	1726	9	parameter	parameter	NN
cord-006860-a3b8hyyr	1726	10	for	for	IN
cord-006860-a3b8hyyr	1726	11	the	the	DT
cord-006860-a3b8hyyr	1726	12	assessment	assessment	NN
cord-006860-a3b8hyyr	1726	13	of	of	IN
cord-006860-a3b8hyyr	1726	14	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	1726	15	during	during	IN
cord-006860-a3b8hyyr	1726	16	plasmapheresis	plasmapheresis	NN
cord-006860-a3b8hyyr	1726	17	.	.	.
cord-006860-a3b8hyyr	1727	1	Several	several	JJ
cord-006860-a3b8hyyr	1727	2	epidemiologic	epidemiologic	JJ
cord-006860-a3b8hyyr	1727	3	studies	study	NNS
cord-006860-a3b8hyyr	1727	4	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	1727	5	that	that	IN
cord-006860-a3b8hyyr	1727	6	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1727	7	is	be	VBZ
cord-006860-a3b8hyyr	1727	8	an	an	DT
cord-006860-a3b8hyyr	1727	9	independent	independent	JJ
cord-006860-a3b8hyyr	1727	10	cardiovascular	cardiovascular	JJ
cord-006860-a3b8hyyr	1727	11	risk	risk	NN
cord-006860-a3b8hyyr	1727	12	factor	factor	NN
cord-006860-a3b8hyyr	1727	13	and	and	CC
cord-006860-a3b8hyyr	1727	14	should	should	MD
cord-006860-a3b8hyyr	1727	15	be	be	VB
cord-006860-a3b8hyyr	1727	16	considered	consider	VBN
cord-006860-a3b8hyyr	1727	17	for	for	IN
cord-006860-a3b8hyyr	1727	18	screening	screen	VBG
cord-006860-a3b8hyyr	1727	19	programs	program	NNS
cord-006860-a3b8hyyr	1727	20	.	.	.
cord-006860-a3b8hyyr	1728	1	Prothrombin	Prothrombin	NNP
cord-006860-a3b8hyyr	1728	2	time	time	NN
cord-006860-a3b8hyyr	1728	3	derived	derive	VBD
cord-006860-a3b8hyyr	1728	4	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1728	5	(	(	-LRB-
cord-006860-a3b8hyyr	1728	6	DF	DF	NNP
cord-006860-a3b8hyyr	1728	7	)	)	-RRB-
cord-006860-a3b8hyyr	1728	8	measurement	measurement	NN
cord-006860-a3b8hyyr	1728	9	combines	combine	VBZ
cord-006860-a3b8hyyr	1728	10	the	the	DT
cord-006860-a3b8hyyr	1728	11	advantage	advantage	NN
cord-006860-a3b8hyyr	1728	12	of	of	IN
cord-006860-a3b8hyyr	1728	13	an	an	DT
cord-006860-a3b8hyyr	1728	14	established	establish	VBN
cord-006860-a3b8hyyr	1728	15	highly	highly	RB
cord-006860-a3b8hyyr	1728	16	reproducible	reproducible	JJ
cord-006860-a3b8hyyr	1728	17	automated	automate	VBN
cord-006860-a3b8hyyr	1728	18	method	method	NN
cord-006860-a3b8hyyr	1728	19	with	with	IN
cord-006860-a3b8hyyr	1728	20	no	no	DT
cord-006860-a3b8hyyr	1728	21	additional	additional	JJ
cord-006860-a3b8hyyr	1728	22	reagents	reagent	NNS
cord-006860-a3b8hyyr	1728	23	,	,	,
cord-006860-a3b8hyyr	1728	24	except	except	IN
cord-006860-a3b8hyyr	1728	25	for	for	IN
cord-006860-a3b8hyyr	1728	26	calibration	calibration	NN
cord-006860-a3b8hyyr	1728	27	.	.	.
cord-006860-a3b8hyyr	1729	1	Several	several	JJ
cord-006860-a3b8hyyr	1729	2	studies	study	NNS
cord-006860-a3b8hyyr	1729	3	showed	show	VBD
cord-006860-a3b8hyyr	1729	4	that	that	IN
cord-006860-a3b8hyyr	1729	5	the	the	DT
cord-006860-a3b8hyyr	1729	6	DF	DF	NNP
cord-006860-a3b8hyyr	1729	7	values	value	NNS
cord-006860-a3b8hyyr	1729	8	correspond	correspond	VBP
cord-006860-a3b8hyyr	1729	9	well	well	RB
cord-006860-a3b8hyyr	1729	10	with	with	IN
cord-006860-a3b8hyyr	1729	11	the	the	DT
cord-006860-a3b8hyyr	1729	12	Clanss	Clanss	NNP
cord-006860-a3b8hyyr	1729	13	method	method	NN
cord-006860-a3b8hyyr	1729	14	except	except	IN
cord-006860-a3b8hyyr	1729	15	in	in	IN
cord-006860-a3b8hyyr	1729	16	cases	case	NNS
cord-006860-a3b8hyyr	1729	17	such	such	JJ
cord-006860-a3b8hyyr	1729	18	as	as	IN
cord-006860-a3b8hyyr	1729	19	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	1729	20	therapy	therapy	NN
cord-006860-a3b8hyyr	1729	21	in	in	IN
cord-006860-a3b8hyyr	1729	22	which	which	WDT
cord-006860-a3b8hyyr	1729	23	the	the	DT
cord-006860-a3b8hyyr	1729	24	DF	DF	NNP
cord-006860-a3b8hyyr	1729	25	results	result	NNS
cord-006860-a3b8hyyr	1729	26	are	be	VBP
cord-006860-a3b8hyyr	1729	27	higher	high	JJR
cord-006860-a3b8hyyr	1729	28	.	.	.
cord-006860-a3b8hyyr	1730	1	However	however	RB
cord-006860-a3b8hyyr	1730	2	,	,	,
cord-006860-a3b8hyyr	1730	3	no	no	DT
cord-006860-a3b8hyyr	1730	4	results	result	NNS
cord-006860-a3b8hyyr	1730	5	exist	exist	VBP
cord-006860-a3b8hyyr	1730	6	whether	whether	IN
cord-006860-a3b8hyyr	1730	7	in	in	IN
cord-006860-a3b8hyyr	1730	8	patients	patient	NNS
cord-006860-a3b8hyyr	1730	9	with	with	IN
cord-006860-a3b8hyyr	1730	10	coronary	coronary	JJ
cord-006860-a3b8hyyr	1730	11	heart	heart	NN
cord-006860-a3b8hyyr	1730	12	disease	disease	NN
cord-006860-a3b8hyyr	1730	13	with	with	IN
cord-006860-a3b8hyyr	1730	14	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1730	15	as	as	IN
cord-006860-a3b8hyyr	1730	16	a	a	DT
cord-006860-a3b8hyyr	1730	17	risk	risk	NN
cord-006860-a3b8hyyr	1730	18	factor	factor	NN
cord-006860-a3b8hyyr	1730	19	the	the	DT
cord-006860-a3b8hyyr	1730	20	DF	DF	NNP
cord-006860-a3b8hyyr	1730	21	values	value	NNS
cord-006860-a3b8hyyr	1730	22	are	be	VBP
cord-006860-a3b8hyyr	1730	23	also	also	RB
cord-006860-a3b8hyyr	1730	24	comparable	comparable	JJ
cord-006860-a3b8hyyr	1730	25	to	to	IN
cord-006860-a3b8hyyr	1730	26	the	the	DT
cord-006860-a3b8hyyr	1730	27	established	establish	VBN
cord-006860-a3b8hyyr	1730	28	Clausss	Clausss	NNP
cord-006860-a3b8hyyr	1730	29	method	method	NN
cord-006860-a3b8hyyr	1730	30	.	.	.
cord-006860-a3b8hyyr	1731	1	The	the	DT
cord-006860-a3b8hyyr	1731	2	aim	aim	NN
cord-006860-a3b8hyyr	1731	3	of	of	IN
cord-006860-a3b8hyyr	1731	4	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1731	5	study	study	NN
cord-006860-a3b8hyyr	1731	6	was	be	VBD
cord-006860-a3b8hyyr	1731	7	to	to	TO
cord-006860-a3b8hyyr	1731	8	compare	compare	VB
cord-006860-a3b8hyyr	1731	9	DF	DF	NNP
cord-006860-a3b8hyyr	1731	10	values	value	NNS
cord-006860-a3b8hyyr	1731	11	to	to	IN
cord-006860-a3b8hyyr	1731	12	Clauss	Clauss	NNP
cord-006860-a3b8hyyr	1731	13	method	method	NN
cord-006860-a3b8hyyr	1731	14	results	result	NNS
cord-006860-a3b8hyyr	1731	15	in	in	IN
cord-006860-a3b8hyyr	1731	16	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	1731	17	patients	patient	NNS
cord-006860-a3b8hyyr	1731	18	,	,	,
cord-006860-a3b8hyyr	1731	19	especially	especially	RB
cord-006860-a3b8hyyr	1731	20	in	in	IN
cord-006860-a3b8hyyr	1731	21	patients	patient	NNS
cord-006860-a3b8hyyr	1731	22	before	before	IN
cord-006860-a3b8hyyr	1731	23	and	and	CC
cord-006860-a3b8hyyr	1731	24	after	after	IN
cord-006860-a3b8hyyr	1731	25	coronary	coronary	JJ
cord-006860-a3b8hyyr	1731	26	bypass	bypass	NN
cord-006860-a3b8hyyr	1731	27	grafting	grafting	NN
cord-006860-a3b8hyyr	1731	28	(	(	-LRB-
cord-006860-a3b8hyyr	1731	29	CAB	cab	NN
cord-006860-a3b8hyyr	1731	30	(	(	-LRB-
cord-006860-a3b8hyyr	1731	31	]	]	-RRB-
cord-006860-a3b8hyyr	1731	32	)	)	-RRB-
cord-006860-a3b8hyyr	1731	33	.	.	.
cord-006860-a3b8hyyr	1732	1	Measurements	measurement	NNS
cord-006860-a3b8hyyr	1732	2	of	of	IN
cord-006860-a3b8hyyr	1732	3	DF	DF	NNP
cord-006860-a3b8hyyr	1732	4	were	be	VBD
cord-006860-a3b8hyyr	1732	5	performed	perform	VBN
cord-006860-a3b8hyyr	1732	6	on	on	IN
cord-006860-a3b8hyyr	1732	7	an	an	DT
cord-006860-a3b8hyyr	1732	8	ACL	ACL	NNP
cord-006860-a3b8hyyr	1732	9	3000	3000	CD
cord-006860-a3b8hyyr	1732	10	(	(	-LRB-
cord-006860-a3b8hyyr	1732	11	IL	IL	NNP
cord-006860-a3b8hyyr	1732	12	)	)	-RRB-
cord-006860-a3b8hyyr	1732	13	using	use	VBG
cord-006860-a3b8hyyr	1732	14	the	the	DT
cord-006860-a3b8hyyr	1732	15	PT	PT	NNP
cord-006860-a3b8hyyr	1732	16	-	-	HYPH
cord-006860-a3b8hyyr	1732	17	Fibrinogen	Fibrinogen	NNP
cord-006860-a3b8hyyr	1732	18	-	-	HYPH
cord-006860-a3b8hyyr	1732	19	HS	HS	NNP
cord-006860-a3b8hyyr	1732	20	reagent	reagent	NN
cord-006860-a3b8hyyr	1732	21	.	.	.
cord-006860-a3b8hyyr	1733	1	Fibrinogen	Fibrinogen	NNP
cord-006860-a3b8hyyr	1733	2	Clanss	Clanss	NNP
cord-006860-a3b8hyyr	1733	3	method	method	NN
cord-006860-a3b8hyyr	1733	4	was	be	VBD
cord-006860-a3b8hyyr	1733	5	done	do	VBN
cord-006860-a3b8hyyr	1733	6	on	on	IN
cord-006860-a3b8hyyr	1733	7	the	the	DT
cord-006860-a3b8hyyr	1733	8	ACL	ACL	NNP
cord-006860-a3b8hyyr	1733	9	using	use	VBG
cord-006860-a3b8hyyr	1733	10	Fibrinogen	Fibrinogen	NNP
cord-006860-a3b8hyyr	1733	11	C	c	NN
cord-006860-a3b8hyyr	1733	12	reagent	reagent	NN
cord-006860-a3b8hyyr	1733	13	(	(	-LRB-
cord-006860-a3b8hyyr	1733	14	IL	IL	NNP
cord-006860-a3b8hyyr	1733	15	)	)	-RRB-
cord-006860-a3b8hyyr	1733	16	and	and	CC
cord-006860-a3b8hyyr	1733	17	on	on	IN
cord-006860-a3b8hyyr	1733	18	a	a	DT
cord-006860-a3b8hyyr	1733	19	KC4	kc4	NN
cord-006860-a3b8hyyr	1733	20	(	(	-LRB-
cord-006860-a3b8hyyr	1733	21	Amelung	Amelung	NNP
cord-006860-a3b8hyyr	1733	22	)	)	-RRB-
cord-006860-a3b8hyyr	1733	23	with	with	IN
cord-006860-a3b8hyyr	1733	24	Fibrinogen	Fibrinogen	NNP
cord-006860-a3b8hyyr	1733	25	a	a	DT
cord-006860-a3b8hyyr	1733	26	reagent	reagent	NN
cord-006860-a3b8hyyr	1733	27	(	(	-LRB-
cord-006860-a3b8hyyr	1733	28	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	1733	29	Maanheim	Maanheim	NNP
cord-006860-a3b8hyyr	1733	30	)	)	-RRB-
cord-006860-a3b8hyyr	1733	31	.	.	.
cord-006860-a3b8hyyr	1734	1	For	for	IN
cord-006860-a3b8hyyr	1734	2	calibration	calibration	NN
cord-006860-a3b8hyyr	1734	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	1734	4	used	use	VBD
cord-006860-a3b8hyyr	1734	5	the	the	DT
cord-006860-a3b8hyyr	1734	6	Calibration	Calibration	NNP
cord-006860-a3b8hyyr	1734	7	plasma	plasma	NN
cord-006860-a3b8hyyr	1734	8	half	half	NN
cord-006860-a3b8hyyr	1734	9	volume	volume	NN
cord-006860-a3b8hyyr	1734	10	(	(	-LRB-
cord-006860-a3b8hyyr	1734	11	It	-PRON-	PRP
cord-006860-a3b8hyyr	1734	12	.	.	.
cord-006860-a3b8hyyr	1734	13	)	)	-RRB-
cord-006860-a3b8hyyr	1735	1	with	with	IN
cord-006860-a3b8hyyr	1735	2	the	the	DT
cord-006860-a3b8hyyr	1735	3	fihrinogen	fihrinogen	NN
cord-006860-a3b8hyyr	1735	4	concentration	concentration	NN
cord-006860-a3b8hyyr	1735	5	proposed	propose	VBN
cord-006860-a3b8hyyr	1735	6	by	by	IN
cord-006860-a3b8hyyr	1735	7	the	the	DT
cord-006860-a3b8hyyr	1735	8	manufacturer	manufacturer	NN
cord-006860-a3b8hyyr	1735	9	.	.	.
cord-006860-a3b8hyyr	1736	1	Plasma	plasma	NN
cord-006860-a3b8hyyr	1736	2	samples	sample	NNS
cord-006860-a3b8hyyr	1736	3	were	be	VBD
cord-006860-a3b8hyyr	1736	4	obtained	obtain	VBN
cord-006860-a3b8hyyr	1736	5	from	from	IN
cord-006860-a3b8hyyr	1736	6	24	24	CD
cord-006860-a3b8hyyr	1736	7	patients	patient	NNS
cord-006860-a3b8hyyr	1736	8	at	at	IN
cord-006860-a3b8hyyr	1736	9	admission	admission	NN
cord-006860-a3b8hyyr	1736	10	before	before	IN
cord-006860-a3b8hyyr	1736	11	CABG	CABG	NNP
cord-006860-a3b8hyyr	1736	12	and	and	CC
cord-006860-a3b8hyyr	1736	13	postoperatively	postoperatively	RB
cord-006860-a3b8hyyr	1736	14	up	up	IN
cord-006860-a3b8hyyr	1736	15	to	to	TO
cord-006860-a3b8hyyr	1736	16	1	1	CD
cord-006860-a3b8hyyr	1736	17	week	week	NN
cord-006860-a3b8hyyr	1736	18	,	,	,
cord-006860-a3b8hyyr	1736	19	and	and	CC
cord-006860-a3b8hyyr	1736	20	from	from	IN
cord-006860-a3b8hyyr	1736	21	23	23	CD
cord-006860-a3b8hyyr	1736	22	healthy	healthy	JJ
cord-006860-a3b8hyyr	1736	23	persons	person	NNS
cord-006860-a3b8hyyr	1736	24	(	(	-LRB-
cord-006860-a3b8hyyr	1736	25	staff	staff	NN
cord-006860-a3b8hyyr	1736	26	)	)	-RRB-
cord-006860-a3b8hyyr	1736	27	.	.	.
cord-006860-a3b8hyyr	1737	1	Within	within	IN
cord-006860-a3b8hyyr	1737	2	assay	assay	NN
cord-006860-a3b8hyyr	1737	3	imprecisious	imprecisious	JJ
cord-006860-a3b8hyyr	1737	4	using	use	VBG
cord-006860-a3b8hyyr	1737	5	normal	normal	JJ
cord-006860-a3b8hyyr	1737	6	and	and	CC
cord-006860-a3b8hyyr	1737	7	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	1737	8	controls	control	NNS
cord-006860-a3b8hyyr	1737	9	(	(	-LRB-
cord-006860-a3b8hyyr	1737	10	IL	IL	NNP
cord-006860-a3b8hyyr	1737	11	)	)	-RRB-
cord-006860-a3b8hyyr	1737	12	were	be	VBD
cord-006860-a3b8hyyr	1737	13	comparable	comparable	JJ
cord-006860-a3b8hyyr	1737	14	with	with	IN
cord-006860-a3b8hyyr	1737	15	both	both	DT
cord-006860-a3b8hyyr	1737	16	methods	method	NNS
cord-006860-a3b8hyyr	1737	17	showing	show	VBG
cord-006860-a3b8hyyr	1737	18	cvs	cvs	NN
cord-006860-a3b8hyyr	1737	19	between	between	IN
cord-006860-a3b8hyyr	1737	20	1.99	1.99	CD
cord-006860-a3b8hyyr	1737	21	and	and	CC
cord-006860-a3b8hyyr	1737	22	4.22	4.22	CD
cord-006860-a3b8hyyr	1737	23	%	%	NN
cord-006860-a3b8hyyr	1737	24	.	.	.
cord-006860-a3b8hyyr	1738	1	In	in	IN
cord-006860-a3b8hyyr	1738	2	normal	normal	JJ
cord-006860-a3b8hyyr	1738	3	healthy	healthy	JJ
cord-006860-a3b8hyyr	1738	4	persons	person	NNS
cord-006860-a3b8hyyr	1738	5	the	the	DT
cord-006860-a3b8hyyr	1738	6	medians	median	NNS
cord-006860-a3b8hyyr	1738	7	of	of	IN
cord-006860-a3b8hyyr	1738	8	the	the	DT
cord-006860-a3b8hyyr	1738	9	DF	DF	NNP
cord-006860-a3b8hyyr	1738	10	and	and	CC
cord-006860-a3b8hyyr	1738	11	the	the	DT
cord-006860-a3b8hyyr	1738	12	Clanss	Clanss	NNP
cord-006860-a3b8hyyr	1738	13	method	method	NN
cord-006860-a3b8hyyr	1738	14	run	run	VBN
cord-006860-a3b8hyyr	1738	15	on	on	IN
cord-006860-a3b8hyyr	1738	16	the	the	DT
cord-006860-a3b8hyyr	1738	17	ACL	ACL	NNP
cord-006860-a3b8hyyr	1738	18	were	be	VBD
cord-006860-a3b8hyyr	1738	19	very	very	RB
cord-006860-a3b8hyyr	1738	20	similar	similar	JJ
cord-006860-a3b8hyyr	1738	21	(	(	-LRB-
cord-006860-a3b8hyyr	1738	22	296	296	CD
cord-006860-a3b8hyyr	1738	23	vs	vs	IN
cord-006860-a3b8hyyr	1738	24	302	302	CD
cord-006860-a3b8hyyr	1738	25	rag	rag	NN
cord-006860-a3b8hyyr	1738	26	/	/	SYM
cord-006860-a3b8hyyr	1738	27	all	all	DT
cord-006860-a3b8hyyr	1738	28	)	)	-RRB-
cord-006860-a3b8hyyr	1738	29	,	,	,
cord-006860-a3b8hyyr	1738	30	whereas	whereas	IN
cord-006860-a3b8hyyr	1738	31	KC4	KC4	NNP
cord-006860-a3b8hyyr	1738	32	values	value	NNS
cord-006860-a3b8hyyr	1738	33	were	be	VBD
cord-006860-a3b8hyyr	1738	34	about	about	RB
cord-006860-a3b8hyyr	1738	35	10	10	CD
cord-006860-a3b8hyyr	1738	36	%	%	NN
cord-006860-a3b8hyyr	1738	37	lower	low	JJR
cord-006860-a3b8hyyr	1738	38	(	(	-LRB-
cord-006860-a3b8hyyr	1738	39	268	268	CD
cord-006860-a3b8hyyr	1738	40	md	md	NNP
cord-006860-a3b8hyyr	1738	41	/	/	SYM
cord-006860-a3b8hyyr	1738	42	dl	dl	NNP
cord-006860-a3b8hyyr	1738	43	)	)	-RRB-
cord-006860-a3b8hyyr	1738	44	.	.	.
cord-006860-a3b8hyyr	1739	1	In	in	IN
cord-006860-a3b8hyyr	1739	2	CABG	CABG	NNP
cord-006860-a3b8hyyr	1739	3	patients	patient	NNS
cord-006860-a3b8hyyr	1739	4	at	at	IN
cord-006860-a3b8hyyr	1739	5	admission	admission	NN
cord-006860-a3b8hyyr	1739	6	we	-PRON-	PRP
cord-006860-a3b8hyyr	1739	7	found	find	VBD
cord-006860-a3b8hyyr	1739	8	the	the	DT
cord-006860-a3b8hyyr	1739	9	same	same	JJ
cord-006860-a3b8hyyr	1739	10	differences	difference	NNS
cord-006860-a3b8hyyr	1739	11	as	as	IN
cord-006860-a3b8hyyr	1739	12	in	in	IN
cord-006860-a3b8hyyr	1739	13	normals	normal	NNS
cord-006860-a3b8hyyr	1739	14	with	with	IN
cord-006860-a3b8hyyr	1739	15	the	the	DT
cord-006860-a3b8hyyr	1739	16	Clanss	Clanss	NNP
cord-006860-a3b8hyyr	1739	17	method	method	NN
cord-006860-a3b8hyyr	1739	18	(	(	-LRB-
cord-006860-a3b8hyyr	1739	19	ACL	ACL	NNP
cord-006860-a3b8hyyr	1739	20	:	:	:
cord-006860-a3b8hyyr	1739	21	363	363	CD
cord-006860-a3b8hyyr	1739	22	vs	vs	IN
cord-006860-a3b8hyyr	1739	23	KC4	KC4	NNP
cord-006860-a3b8hyyr	1739	24	:	:	:
cord-006860-a3b8hyyr	1740	1	337rag	337rag	LS
cord-006860-a3b8hyyr	1740	2	/	/	SYM
cord-006860-a3b8hyyr	1740	3	all	all	DT
cord-006860-a3b8hyyr	1740	4	)	)	-RRB-
cord-006860-a3b8hyyr	1740	5	,	,	,
cord-006860-a3b8hyyr	1740	6	however	however	RB
cord-006860-a3b8hyyr	1740	7	the	the	DT
cord-006860-a3b8hyyr	1740	8	DF	DF	NNP
cord-006860-a3b8hyyr	1740	9	values	value	NNS
cord-006860-a3b8hyyr	1740	10	were	be	VBD
cord-006860-a3b8hyyr	1740	11	siginficantly	siginficantly	RB
cord-006860-a3b8hyyr	1740	12	higher	high	JJR
cord-006860-a3b8hyyr	1740	13	(	(	-LRB-
cord-006860-a3b8hyyr	1740	14	median	median	JJ
cord-006860-a3b8hyyr	1740	15	418mg	418mg	NNP
cord-006860-a3b8hyyr	1740	16	/	/	SYM
cord-006860-a3b8hyyr	1740	17	dl	dl	NN
cord-006860-a3b8hyyr	1740	18	)	)	-RRB-
cord-006860-a3b8hyyr	1740	19	.	.	.
cord-006860-a3b8hyyr	1741	1	If	if	IN
cord-006860-a3b8hyyr	1741	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	1741	3	took	take	VBD
cord-006860-a3b8hyyr	1741	4	a	a	DT
cord-006860-a3b8hyyr	1741	5	cutoff	cutoff	NN
cord-006860-a3b8hyyr	1741	6	value	value	NN
cord-006860-a3b8hyyr	1741	7	of	of	IN
cord-006860-a3b8hyyr	1741	8	320	320	CD
cord-006860-a3b8hyyr	1741	9	mg	mg	NNP
cord-006860-a3b8hyyr	1741	10	/	/	SYM
cord-006860-a3b8hyyr	1741	11	dl	dl	NNP
cord-006860-a3b8hyyr	1741	12	,	,	,
cord-006860-a3b8hyyr	1741	13	as	as	IN
cord-006860-a3b8hyyr	1741	14	suggested	suggest	VBN
cord-006860-a3b8hyyr	1741	15	by	by	IN
cord-006860-a3b8hyyr	1741	16	the	the	DT
cord-006860-a3b8hyyr	1741	17	results	result	NNS
cord-006860-a3b8hyyr	1741	18	from	from	IN
cord-006860-a3b8hyyr	1741	19	the	the	DT
cord-006860-a3b8hyyr	1741	20	Northwick	Northwick	NNP
cord-006860-a3b8hyyr	1741	21	Park	Park	NNP
cord-006860-a3b8hyyr	1741	22	Heart	Heart	NNP
cord-006860-a3b8hyyr	1741	23	Study	Study	NNP
cord-006860-a3b8hyyr	1741	24	,	,	,
cord-006860-a3b8hyyr	1741	25	we	-PRON-	PRP
cord-006860-a3b8hyyr	1741	26	would	would	MD
cord-006860-a3b8hyyr	1741	27	categorize	categorize	VB
cord-006860-a3b8hyyr	1741	28	into	into	IN
cord-006860-a3b8hyyr	1741	29	the	the	DT
cord-006860-a3b8hyyr	1741	30	high	high	JJ
cord-006860-a3b8hyyr	1741	31	risk	risk	NN
cord-006860-a3b8hyyr	1741	32	group	group	NN
cord-006860-a3b8hyyr	1741	33	21	21	CD
cord-006860-a3b8hyyr	1741	34	out	out	IN
cord-006860-a3b8hyyr	1741	35	of	of	IN
cord-006860-a3b8hyyr	1741	36	24	24	CD
cord-006860-a3b8hyyr	1741	37	patients	patient	NNS
cord-006860-a3b8hyyr	1741	38	using	use	VBG
cord-006860-a3b8hyyr	1741	39	the	the	DT
cord-006860-a3b8hyyr	1741	40	DF	DF	NNP
cord-006860-a3b8hyyr	1741	41	method	method	NN
cord-006860-a3b8hyyr	1741	42	,	,	,
cord-006860-a3b8hyyr	1741	43	20	20	CD
cord-006860-a3b8hyyr	1741	44	with	with	IN
cord-006860-a3b8hyyr	1741	45	the	the	DT
cord-006860-a3b8hyyr	1741	46	Clanss	Clanss	NNP
cord-006860-a3b8hyyr	1741	47	-	-	HYPH
cord-006860-a3b8hyyr	1741	48	ACL	ACL	NNP
cord-006860-a3b8hyyr	1741	49	method	method	NN
cord-006860-a3b8hyyr	1741	50	and	and	CC
cord-006860-a3b8hyyr	1741	51	16	16	CD
cord-006860-a3b8hyyr	1741	52	with	with	IN
cord-006860-a3b8hyyr	1741	53	the	the	DT
cord-006860-a3b8hyyr	1741	54	Clanss	Clanss	NNP
cord-006860-a3b8hyyr	1741	55	-	-	HYPH
cord-006860-a3b8hyyr	1741	56	KC4	KC4	NNP
cord-006860-a3b8hyyr	1741	57	method	method	NN
cord-006860-a3b8hyyr	1741	58	,	,	,
cord-006860-a3b8hyyr	1741	59	i.e.	i.e.	FW
cord-006860-a3b8hyyr	1741	60	nearly	nearly	RB
cord-006860-a3b8hyyr	1741	61	30	30	CD
cord-006860-a3b8hyyr	1741	62	%	%	NN
cord-006860-a3b8hyyr	1741	63	more	more	JJR
cord-006860-a3b8hyyr	1741	64	patients	patient	NNS
cord-006860-a3b8hyyr	1741	65	were	be	VBD
cord-006860-a3b8hyyr	1741	66	classified	classify	VBN
cord-006860-a3b8hyyr	1741	67	in	in	IN
cord-006860-a3b8hyyr	1741	68	the	the	DT
cord-006860-a3b8hyyr	1741	69	high	high	JJ
cord-006860-a3b8hyyr	1741	70	risk	risk	NN
cord-006860-a3b8hyyr	1741	71	group	group	NN
cord-006860-a3b8hyyr	1741	72	using	use	VBG
cord-006860-a3b8hyyr	1741	73	the	the	DT
cord-006860-a3b8hyyr	1741	74	DF	DF	NNP
cord-006860-a3b8hyyr	1741	75	method	method	NN
cord-006860-a3b8hyyr	1741	76	.	.	.
cord-006860-a3b8hyyr	1742	1	Postoperative	postoperative	JJ
cord-006860-a3b8hyyr	1742	2	samples	sample	NNS
cord-006860-a3b8hyyr	1742	3	showed	show	VBD
cord-006860-a3b8hyyr	1742	4	the	the	DT
cord-006860-a3b8hyyr	1742	5	expected	expect	VBN
cord-006860-a3b8hyyr	1742	6	increases	increase	NNS
cord-006860-a3b8hyyr	1742	7	due	due	IN
cord-006860-a3b8hyyr	1742	8	to	to	IN
cord-006860-a3b8hyyr	1742	9	the	the	DT
cord-006860-a3b8hyyr	1742	10	acute	acute	JJ
cord-006860-a3b8hyyr	1742	11	phase	phase	NN
cord-006860-a3b8hyyr	1742	12	response	response	NN
cord-006860-a3b8hyyr	1742	13	with	with	IN
cord-006860-a3b8hyyr	1742	14	the	the	DT
cord-006860-a3b8hyyr	1742	15	same	same	JJ
cord-006860-a3b8hyyr	1742	16	magnitude	magnitude	NN
cord-006860-a3b8hyyr	1742	17	of	of	IN
cord-006860-a3b8hyyr	1742	18	differences	difference	NNS
cord-006860-a3b8hyyr	1742	19	.	.	.
cord-006860-a3b8hyyr	1743	1	Because	because	IN
cord-006860-a3b8hyyr	1743	2	of	of	IN
cord-006860-a3b8hyyr	1743	3	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1743	4	rapidity	rapidity	NN
cord-006860-a3b8hyyr	1743	5	and	and	CC
cord-006860-a3b8hyyr	1743	6	reproducibility	reproducibility	NN
cord-006860-a3b8hyyr	1743	7	the	the	DT
cord-006860-a3b8hyyr	1743	8	DF	DF	NNP
cord-006860-a3b8hyyr	1743	9	method	method	NN
cord-006860-a3b8hyyr	1743	10	is	be	VBZ
cord-006860-a3b8hyyr	1743	11	well	well	RB
cord-006860-a3b8hyyr	1743	12	suited	suited	JJ
cord-006860-a3b8hyyr	1743	13	for	for	IN
cord-006860-a3b8hyyr	1743	14	routine	routine	JJ
cord-006860-a3b8hyyr	1743	15	measurements	measurement	NNS
cord-006860-a3b8hyyr	1743	16	,	,	,
cord-006860-a3b8hyyr	1743	17	however	however	RB
cord-006860-a3b8hyyr	1743	18	,	,	,
cord-006860-a3b8hyyr	1743	19	standardization	standardization	NN
cord-006860-a3b8hyyr	1743	20	remains	remain	VBZ
cord-006860-a3b8hyyr	1743	21	an	an	DT
cord-006860-a3b8hyyr	1743	22	urgent	urgent	JJ
cord-006860-a3b8hyyr	1743	23	task	task	NN
cord-006860-a3b8hyyr	1743	24	in	in	IN
cord-006860-a3b8hyyr	1743	25	order	order	NN
cord-006860-a3b8hyyr	1743	26	to	to	TO
cord-006860-a3b8hyyr	1743	27	avoid	avoid	VB
cord-006860-a3b8hyyr	1743	28	misinterpretation	misinterpretation	NN
cord-006860-a3b8hyyr	1743	29	of	of	IN
cord-006860-a3b8hyyr	1743	30	results	result	NNS
cord-006860-a3b8hyyr	1743	31	.	.	.
cord-006860-a3b8hyyr	1744	1	For	for	IN
cord-006860-a3b8hyyr	1744	2	fibdnogen	fibdnogen	NNP
cord-006860-a3b8hyyr	1744	3	measurements	measurement	NNS
cord-006860-a3b8hyyr	1744	4	in	in	IN
cord-006860-a3b8hyyr	1744	5	clinical	clinical	JJ
cord-006860-a3b8hyyr	1744	6	laboratories	laboratory	NNS
cord-006860-a3b8hyyr	1744	7	,	,	,
cord-006860-a3b8hyyr	1744	8	the	the	DT
cord-006860-a3b8hyyr	1744	9	two	two	CD
cord-006860-a3b8hyyr	1744	10	most	most	RBS
cord-006860-a3b8hyyr	1744	11	widely	widely	RB
cord-006860-a3b8hyyr	1744	12	used	use	VBN
cord-006860-a3b8hyyr	1744	13	methods	method	NNS
cord-006860-a3b8hyyr	1744	14	are	be	VBP
cord-006860-a3b8hyyr	1744	15	the	the	DT
cord-006860-a3b8hyyr	1744	16	clotting	clotting	NN
cord-006860-a3b8hyyr	1744	17	time	time	NN
cord-006860-a3b8hyyr	1744	18	method	method	NN
cord-006860-a3b8hyyr	1744	19	according	accord	VBG
cord-006860-a3b8hyyr	1744	20	to	to	IN
cord-006860-a3b8hyyr	1744	21	CLAUSS	CLAUSS	NNP
cord-006860-a3b8hyyr	1744	22	(	(	-LRB-
cord-006860-a3b8hyyr	1744	23	CFIB	CFIB	NNP
cord-006860-a3b8hyyr	1744	24	)	)	-RRB-
cord-006860-a3b8hyyr	1744	25	and	and	CC
cord-006860-a3b8hyyr	1744	26	the	the	DT
cord-006860-a3b8hyyr	1744	27	sn	sn	NNP
cord-006860-a3b8hyyr	1744	28	called	call	VBD
cord-006860-a3b8hyyr	1744	29	"	"	``
cord-006860-a3b8hyyr	1744	30	derived	derive	VBN
cord-006860-a3b8hyyr	1744	31	"	"	''
cord-006860-a3b8hyyr	1744	32	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1744	33	method	method	NN
cord-006860-a3b8hyyr	1744	34	(	(	-LRB-
cord-006860-a3b8hyyr	1744	35	DFIB	DFIB	NNP
cord-006860-a3b8hyyr	1744	36	)	)	-RRB-
cord-006860-a3b8hyyr	1744	37	implemented	implement	VBN
cord-006860-a3b8hyyr	1744	38	in	in	IN
cord-006860-a3b8hyyr	1744	39	optical	optical	JJ
cord-006860-a3b8hyyr	1744	40	coagulometera	coagulometera	NN
cord-006860-a3b8hyyr	1744	41	with	with	IN
cord-006860-a3b8hyyr	1744	42	the	the	DT
cord-006860-a3b8hyyr	1744	43	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1744	44	concentration	concentration	NN
cord-006860-a3b8hyyr	1744	45	being	be	VBG
cord-006860-a3b8hyyr	1744	46	derived	derive	VBN
cord-006860-a3b8hyyr	1744	47	flora	flora	NNS
cord-006860-a3b8hyyr	1745	1	the	the	DT
cord-006860-a3b8hyyr	1745	2	optical	optical	JJ
cord-006860-a3b8hyyr	1745	3	density	density	NN
cord-006860-a3b8hyyr	1745	4	of	of	IN
cord-006860-a3b8hyyr	1745	5	the	the	DT
cord-006860-a3b8hyyr	1745	6	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1745	7	clot	clot	NN
cord-006860-a3b8hyyr	1745	8	in	in	IN
cord-006860-a3b8hyyr	1745	9	a	a	DT
cord-006860-a3b8hyyr	1745	10	standard	standard	JJ
cord-006860-a3b8hyyr	1745	11	prothrnmbin	prothrnmbin	NN
cord-006860-a3b8hyyr	1745	12	time	time	NN
cord-006860-a3b8hyyr	1745	13	(	(	-LRB-
cord-006860-a3b8hyyr	1745	14	PT	pt	NN
cord-006860-a3b8hyyr	1745	15	)	)	-RRB-
cord-006860-a3b8hyyr	1745	16	assay	assay	NN
cord-006860-a3b8hyyr	1745	17	.	.	.
cord-006860-a3b8hyyr	1746	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1746	2	is	be	VBZ
cord-006860-a3b8hyyr	1746	3	well	well	RB
cord-006860-a3b8hyyr	1746	4	known	know	VBN
cord-006860-a3b8hyyr	1746	5	that	that	IN
cord-006860-a3b8hyyr	1746	6	under	under	IN
cord-006860-a3b8hyyr	1746	7	certain	certain	JJ
cord-006860-a3b8hyyr	1746	8	circumstances	circumstance	NNS
cord-006860-a3b8hyyr	1746	9	,	,	,
cord-006860-a3b8hyyr	1746	10	e.g.	e.g.	RB
cord-006860-a3b8hyyr	1746	11	in	in	IN
cord-006860-a3b8hyyr	1746	12	the	the	DT
cord-006860-a3b8hyyr	1746	13	presence	presence	NN
cord-006860-a3b8hyyr	1746	14	of	of	IN
cord-006860-a3b8hyyr	1746	15	fibrin(ogen	fibrin(ogen	NN
cord-006860-a3b8hyyr	1746	16	)	)	-RRB-
cord-006860-a3b8hyyr	1746	17	degradation	degradation	NN
cord-006860-a3b8hyyr	1746	18	products	product	NNS
cord-006860-a3b8hyyr	1746	19	(	(	-LRB-
cord-006860-a3b8hyyr	1746	20	FDP	FDP	NNP
cord-006860-a3b8hyyr	1746	21	)	)	-RRB-
cord-006860-a3b8hyyr	1746	22	,	,	,
cord-006860-a3b8hyyr	1746	23	there	there	EX
cord-006860-a3b8hyyr	1746	24	is	be	VBZ
cord-006860-a3b8hyyr	1746	25	a	a	DT
cord-006860-a3b8hyyr	1746	26	discrepancy	discrepancy	NN
cord-006860-a3b8hyyr	1746	27	between	between	IN
cord-006860-a3b8hyyr	1746	28	the	the	DT
cord-006860-a3b8hyyr	1746	29	two	two	CD
cord-006860-a3b8hyyr	1746	30	methods	method	NNS
cord-006860-a3b8hyyr	1746	31	with	with	IN
cord-006860-a3b8hyyr	1746	32	higher	high	JJR
cord-006860-a3b8hyyr	1746	33	values	value	NNS
cord-006860-a3b8hyyr	1746	34	for	for	IN
cord-006860-a3b8hyyr	1746	35	DFIB	DFIB	NNS
cord-006860-a3b8hyyr	1746	36	than	than	IN
cord-006860-a3b8hyyr	1746	37	for	for	IN
cord-006860-a3b8hyyr	1746	38	CFIB	CFIB	NNP
cord-006860-a3b8hyyr	1746	39	.	.	.
cord-006860-a3b8hyyr	1747	1	Yet	yet	RB
cord-006860-a3b8hyyr	1747	2	the	the	DT
cord-006860-a3b8hyyr	1747	3	opposite	opposite	JJ
cord-006860-a3b8hyyr	1747	4	discrepancy	discrepancy	NN
cord-006860-a3b8hyyr	1747	5	,	,	,
cord-006860-a3b8hyyr	1747	6	i.e.	i.e.	FW
cord-006860-a3b8hyyr	1747	7	fibrinogen	fibrinogen	JJ
cord-006860-a3b8hyyr	1747	8	values	value	NNS
cord-006860-a3b8hyyr	1747	9	derived	derive	VBN
cord-006860-a3b8hyyr	1747	10	from	from	IN
cord-006860-a3b8hyyr	1747	11	the	the	DT
cord-006860-a3b8hyyr	1747	12	optical	optical	JJ
cord-006860-a3b8hyyr	1747	13	density	density	NN
cord-006860-a3b8hyyr	1747	14	of	of	IN
cord-006860-a3b8hyyr	1747	15	the	the	DT
cord-006860-a3b8hyyr	1747	16	clot	clot	NN
cord-006860-a3b8hyyr	1747	17	grossly	grossly	RB
cord-006860-a3b8hyyr	1747	18	lower	lower	RBR
cord-006860-a3b8hyyr	1747	19	than	than	IN
cord-006860-a3b8hyyr	1747	20	values	value	NNS
cord-006860-a3b8hyyr	1747	21	from	from	IN
cord-006860-a3b8hyyr	1747	22	dotting	dot	VBG
cord-006860-a3b8hyyr	1747	23	time	time	NN
cord-006860-a3b8hyyr	1747	24	assays	assay	NNS
cord-006860-a3b8hyyr	1747	25	,	,	,
cord-006860-a3b8hyyr	1747	26	seems	seem	VBZ
cord-006860-a3b8hyyr	1747	27	to	to	TO
cord-006860-a3b8hyyr	1747	28	be	be	VB
cord-006860-a3b8hyyr	1747	29	very	very	RB
cord-006860-a3b8hyyr	1747	30	rare	rare	JJ
cord-006860-a3b8hyyr	1747	31	and	and	CC
cord-006860-a3b8hyyr	1747	32	is	be	VBZ
cord-006860-a3b8hyyr	1747	33	poorly	poorly	RB
cord-006860-a3b8hyyr	1747	34	understood	understand	VBN
cord-006860-a3b8hyyr	1747	35	so	so	RB
cord-006860-a3b8hyyr	1747	36	far	far	RB
cord-006860-a3b8hyyr	1747	37	.	.	.
cord-006860-a3b8hyyr	1748	1	The	the	DT
cord-006860-a3b8hyyr	1748	2	patient	patient	NN
cord-006860-a3b8hyyr	1748	3	(	(	-LRB-
cord-006860-a3b8hyyr	1748	4	male	male	JJ
cord-006860-a3b8hyyr	1748	5	,	,	,
cord-006860-a3b8hyyr	1748	6	26	26	CD
cord-006860-a3b8hyyr	1748	7	years	year	NNS
cord-006860-a3b8hyyr	1748	8	)	)	-RRB-
cord-006860-a3b8hyyr	1748	9	had	have	VBD
cord-006860-a3b8hyyr	1748	10	ingested	ingest	VBN
cord-006860-a3b8hyyr	1748	11	the	the	DT
cord-006860-a3b8hyyr	1748	12	esterase	esterase	NN
cord-006860-a3b8hyyr	1748	13	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	1748	14	parathion	parathion	NN
cord-006860-a3b8hyyr	1748	15	(	(	-LRB-
cord-006860-a3b8hyyr	1748	16	E605	E605	NNP
cord-006860-a3b8hyyr	1748	17	)	)	-RRB-
cord-006860-a3b8hyyr	1748	18	in	in	IN
cord-006860-a3b8hyyr	1748	19	an	an	DT
cord-006860-a3b8hyyr	1748	20	attempt	attempt	NN
cord-006860-a3b8hyyr	1748	21	o	o	NN
cord-006860-a3b8hyyr	1748	22	f	f	NN
cord-006860-a3b8hyyr	1748	23	suizide	suizide	NN
cord-006860-a3b8hyyr	1748	24	and	and	CC
cord-006860-a3b8hyyr	1748	25	was	be	VBD
cord-006860-a3b8hyyr	1748	26	treated	treat	VBN
cord-006860-a3b8hyyr	1748	27	with	with	IN
cord-006860-a3b8hyyr	1748	28	high	high	JJ
cord-006860-a3b8hyyr	1748	29	doses	dose	NNS
cord-006860-a3b8hyyr	1748	30	of	of	IN
cord-006860-a3b8hyyr	1748	31	atmpin	atmpin	NNP
cord-006860-a3b8hyyr	1748	32	.	.	.
cord-006860-a3b8hyyr	1749	1	He	-PRON-	PRP
cord-006860-a3b8hyyr	1749	2	had	have	VBD
cord-006860-a3b8hyyr	1749	3	no	no	DT
cord-006860-a3b8hyyr	1749	4	clinical	clinical	JJ
cord-006860-a3b8hyyr	1749	5	signs	sign	NNS
cord-006860-a3b8hyyr	1749	6	or	or	CC
cord-006860-a3b8hyyr	1749	7	history	history	NN
cord-006860-a3b8hyyr	1749	8	or	or	CC
cord-006860-a3b8hyyr	1749	9	family	family	NN
cord-006860-a3b8hyyr	1749	10	history	history	NN
cord-006860-a3b8hyyr	1749	11	of	of	IN
cord-006860-a3b8hyyr	1749	12	bleeding	bleed	VBG
cord-006860-a3b8hyyr	1749	13	or	or	CC
cord-006860-a3b8hyyr	1749	14	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	1749	15	disorders	disorder	NNS
cord-006860-a3b8hyyr	1749	16	.	.	.
cord-006860-a3b8hyyr	1750	1	Except	except	IN
cord-006860-a3b8hyyr	1750	2	for	for	IN
cord-006860-a3b8hyyr	1750	3	a	a	DT
cord-006860-a3b8hyyr	1750	4	very	very	RB
cord-006860-a3b8hyyr	1750	5	low	low	JJ
cord-006860-a3b8hyyr	1750	6	pseudocholinesterase	pseudocholinesterase	NN
cord-006860-a3b8hyyr	1750	7	activity	activity	NN
cord-006860-a3b8hyyr	1750	8	,	,	,
cord-006860-a3b8hyyr	1750	9	all	all	DT
cord-006860-a3b8hyyr	1750	10	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1750	11	results	result	NNS
cord-006860-a3b8hyyr	1750	12	were	be	VBD
cord-006860-a3b8hyyr	1750	13	normal	normal	JJ
cord-006860-a3b8hyyr	1750	14	ineinding	ineinde	VBG
cord-006860-a3b8hyyr	1750	15	PT	pt	NN
cord-006860-a3b8hyyr	1750	16	,	,	,
cord-006860-a3b8hyyr	1750	17	aFFT	afft	NN
cord-006860-a3b8hyyr	1750	18	,	,	,
cord-006860-a3b8hyyr	1750	19	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1750	20	time	time	NN
cord-006860-a3b8hyyr	1750	21	,	,	,
cord-006860-a3b8hyyr	1750	22	and	and	CC
cord-006860-a3b8hyyr	1750	23	factor	factor	NN
cord-006860-a3b8hyyr	1750	24	XiII	XiII	NNP
cord-006860-a3b8hyyr	1750	25	.	.	.
cord-006860-a3b8hyyr	1751	1	PT	PT	NNP
cord-006860-a3b8hyyr	1751	2	and	and	CC
cord-006860-a3b8hyyr	1751	3	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	1751	4	did	do	VBD
cord-006860-a3b8hyyr	1751	5	nnt	nnt	VB
cord-006860-a3b8hyyr	1751	6	differ	differ	VB
cord-006860-a3b8hyyr	1751	7	between	between	IN
cord-006860-a3b8hyyr	1751	8	an	an	DT
cord-006860-a3b8hyyr	1751	9	optical	optical	JJ
cord-006860-a3b8hyyr	1751	10	COagulometer	COagulometer	NNP
cord-006860-a3b8hyyr	1751	11	(	(	-LRB-
cord-006860-a3b8hyyr	1751	12	Electra	Electra	NNP
cord-006860-a3b8hyyr	1751	13	1000C	1000C	NNP
cord-006860-a3b8hyyr	1751	14	,	,	,
cord-006860-a3b8hyyr	1751	15	MLA	MLA	NNP
cord-006860-a3b8hyyr	1751	16	)	)	-RRB-
cord-006860-a3b8hyyr	1751	17	and	and	CC
cord-006860-a3b8hyyr	1751	18	a	a	DT
cord-006860-a3b8hyyr	1751	19	mechanical	mechanical	JJ
cord-006860-a3b8hyyr	1751	20	one	one	NN
cord-006860-a3b8hyyr	1751	21	(	(	-LRB-
cord-006860-a3b8hyyr	1751	22	KC	KC	NNP
cord-006860-a3b8hyyr	1751	23	..	..	NNP
cord-006860-a3b8hyyr	1751	24	4	4	CD
cord-006860-a3b8hyyr	1751	25	,	,	,
cord-006860-a3b8hyyr	1751	26	Amelung	Amelung	NNP
cord-006860-a3b8hyyr	1751	27	)	)	-RRB-
cord-006860-a3b8hyyr	1751	28	.	.	.
cord-006860-a3b8hyyr	1752	1	There	there	EX
cord-006860-a3b8hyyr	1752	2	was	be	VBD
cord-006860-a3b8hyyr	1752	3	no	no	DT
cord-006860-a3b8hyyr	1752	4	evidence	evidence	NN
cord-006860-a3b8hyyr	1752	5	of	of	IN
cord-006860-a3b8hyyr	1752	6	disorders	disorder	NNS
cord-006860-a3b8hyyr	1752	7	known	know	VBN
cord-006860-a3b8hyyr	1752	8	to	to	TO
cord-006860-a3b8hyyr	1752	9	interfere	interfere	VB
cord-006860-a3b8hyyr	1752	10	with	with	IN
cord-006860-a3b8hyyr	1752	11	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	1752	12	like	like	IN
cord-006860-a3b8hyyr	1752	13	paraproteinemia	paraproteinemia	NNP
cord-006860-a3b8hyyr	1752	14	or	or	CC
cord-006860-a3b8hyyr	1752	15	dyslipldemia	dyslipldemia	NNP
cord-006860-a3b8hyyr	1752	16	.	.	.
cord-006860-a3b8hyyr	1753	1	However	however	RB
cord-006860-a3b8hyyr	1753	2	,	,	,
cord-006860-a3b8hyyr	1753	3	in	in	IN
cord-006860-a3b8hyyr	1753	4	all	all	DT
cord-006860-a3b8hyyr	1753	5	7	7	CD
cord-006860-a3b8hyyr	1753	6	blood	blood	NN
cord-006860-a3b8hyyr	1753	7	samples	sample	NNS
cord-006860-a3b8hyyr	1753	8	received	receive	VBN
cord-006860-a3b8hyyr	1753	9	for	for	IN
cord-006860-a3b8hyyr	1753	10	dotting	dot	VBG
cord-006860-a3b8hyyr	1753	11	tests	test	NNS
cord-006860-a3b8hyyr	1753	12	during	during	IN
cord-006860-a3b8hyyr	1753	13	a	a	DT
cord-006860-a3b8hyyr	1753	14	period	period	NN
cord-006860-a3b8hyyr	1753	15	of	of	IN
cord-006860-a3b8hyyr	1753	16	7	7	CD
cord-006860-a3b8hyyr	1753	17	days	day	NNS
cord-006860-a3b8hyyr	1753	18	the	the	DT
cord-006860-a3b8hyyr	1753	19	macroscopic	macroscopic	JJ
cord-006860-a3b8hyyr	1753	20	appearance	appearance	NN
cord-006860-a3b8hyyr	1753	21	of	of	IN
cord-006860-a3b8hyyr	1753	22	the	the	DT
cord-006860-a3b8hyyr	1753	23	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1753	24	clot	clot	NN
cord-006860-a3b8hyyr	1753	25	was	be	VBD
cord-006860-a3b8hyyr	1753	26	quite	quite	RB
cord-006860-a3b8hyyr	1753	27	unusual	unusual	JJ
cord-006860-a3b8hyyr	1753	28	(	(	-LRB-
cord-006860-a3b8hyyr	1753	29	only	only	RB
cord-006860-a3b8hyyr	1753	30	slightly	slightly	RB
cord-006860-a3b8hyyr	1753	31	turbid	turbid	JJ
cord-006860-a3b8hyyr	1753	32	/	/	,
cord-006860-a3b8hyyr	1753	33	almost	almost	RB
cord-006860-a3b8hyyr	1753	34	transparent	transparent	JJ
cord-006860-a3b8hyyr	1753	35	)	)	-RRB-
cord-006860-a3b8hyyr	1753	36	and	and	CC
cord-006860-a3b8hyyr	1753	37	there	there	EX
cord-006860-a3b8hyyr	1753	38	was	be	VBD
cord-006860-a3b8hyyr	1753	39	a	a	DT
cord-006860-a3b8hyyr	1753	40	striking	striking	JJ
cord-006860-a3b8hyyr	1753	41	discrepancy	discrepancy	NN
cord-006860-a3b8hyyr	1753	42	between	between	IN
cord-006860-a3b8hyyr	1753	43	a	a	DT
cord-006860-a3b8hyyr	1753	44	very	very	RB
cord-006860-a3b8hyyr	1753	45	low	low	JJ
cord-006860-a3b8hyyr	1753	46	or	or	CC
cord-006860-a3b8hyyr	1753	47	low	low	JJ
cord-006860-a3b8hyyr	1753	48	DFIB	DFIB	NNS
cord-006860-a3b8hyyr	1753	49	on	on	IN
cord-006860-a3b8hyyr	1753	50	the	the	DT
cord-006860-a3b8hyyr	1753	51	Electra	Electra	NNP
cord-006860-a3b8hyyr	1753	52	(	(	-LRB-
cord-006860-a3b8hyyr	1753	53	PT	pt	NN
cord-006860-a3b8hyyr	1753	54	reagent	reagent	NN
cord-006860-a3b8hyyr	1753	55	:	:	:
cord-006860-a3b8hyyr	1753	56	Thromboplastin	Thromboplastin	NNP
cord-006860-a3b8hyyr	1753	57	IS	be	VBZ
cord-006860-a3b8hyyr	1753	58	,	,	,
cord-006860-a3b8hyyr	1753	59	Dade	Dade	NNP
cord-006860-a3b8hyyr	1753	60	)	)	-RRB-
cord-006860-a3b8hyyr	1753	61	and	and	CC
cord-006860-a3b8hyyr	1753	62	a	a	DT
cord-006860-a3b8hyyr	1753	63	normal	normal	JJ
cord-006860-a3b8hyyr	1753	64	or	or	CC
cord-006860-a3b8hyyr	1753	65	high	high	JJ
cord-006860-a3b8hyyr	1753	66	CFIB	CFIB	NNP
cord-006860-a3b8hyyr	1753	67	(	(	-LRB-
cord-006860-a3b8hyyr	1753	68	KC4	KC4	NNP
cord-006860-a3b8hyyr	1753	69	;	;	,
cord-006860-a3b8hyyr	1753	70	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1753	71	reagent	reagent	NN
cord-006860-a3b8hyyr	1753	72	,	,	,
cord-006860-a3b8hyyr	1753	73	Dade	Dade	NNP
cord-006860-a3b8hyyr	1753	74	)	)	-RRB-
cord-006860-a3b8hyyr	1753	75	.	.	.
cord-006860-a3b8hyyr	1754	1	On	on	IN
cord-006860-a3b8hyyr	1754	2	admission	admission	NN
cord-006860-a3b8hyyr	1754	3	,	,	,
cord-006860-a3b8hyyr	1754	4	values	value	NNS
cord-006860-a3b8hyyr	1754	5	were	be	VBD
cord-006860-a3b8hyyr	1754	6	57	57	CD
cord-006860-a3b8hyyr	1754	7	mgMl	mgMl	VBN
cord-006860-a3b8hyyr	1754	8	(	(	-LRB-
cord-006860-a3b8hyyr	1754	9	derived	derive	VBN
cord-006860-a3b8hyyr	1754	10	)	)	-RRB-
cord-006860-a3b8hyyr	1754	11	vs.	vs.	FW
cord-006860-a3b8hyyr	1754	12	275	275	CD
cord-006860-a3b8hyyr	1754	13	mgldl	mgldl	NNS
cord-006860-a3b8hyyr	1754	14	(	(	-LRB-
cord-006860-a3b8hyyr	1754	15	CLAUSS	CLAUSS	NNP
cord-006860-a3b8hyyr	1754	16	)	)	-RRB-
cord-006860-a3b8hyyr	1754	17	.	.	.
cord-006860-a3b8hyyr	1755	1	CFIB	CFIB	NNP
cord-006860-a3b8hyyr	1755	2	rose	rise	VBD
cord-006860-a3b8hyyr	1755	3	to	to	IN
cord-006860-a3b8hyyr	1755	4	S42	S42	NNP
cord-006860-a3b8hyyr	1755	5	mg]dl	mg]dl	NN
cord-006860-a3b8hyyr	1755	6	with	with	IN
cord-006860-a3b8hyyr	1755	7	DFIB	DFIB	NNS
cord-006860-a3b8hyyr	1755	8	at	at	IN
cord-006860-a3b8hyyr	1755	9	155	155	CD
cord-006860-a3b8hyyr	1755	10	mg	mg	NNP
cord-006860-a3b8hyyr	1755	11	/	/	SYM
cord-006860-a3b8hyyr	1755	12	dl	dl	NN
cord-006860-a3b8hyyr	1755	13	in	in	IN
cord-006860-a3b8hyyr	1755	14	the	the	DT
cord-006860-a3b8hyyr	1755	15	last	last	JJ
cord-006860-a3b8hyyr	1755	16	sample	sample	NN
cord-006860-a3b8hyyr	1755	17	on	on	IN
cord-006860-a3b8hyyr	1755	18	day	day	NN
cord-006860-a3b8hyyr	1755	19	7	7	CD
cord-006860-a3b8hyyr	1755	20	.	.	.
cord-006860-a3b8hyyr	1756	1	~	~	NFP
cord-006860-a3b8hyyr	1756	2	al	al	NNP
cord-006860-a3b8hyyr	1756	3	!	!	.
cord-006860-a3b8hyyr	1757	1	samples	sample	NNS
cord-006860-a3b8hyyr	1757	2	DFIB	DFIB	NNP
cord-006860-a3b8hyyr	1757	3	was	be	VBD
cord-006860-a3b8hyyr	1757	4	about	about	RB
cord-006860-a3b8hyyr	1757	5	20	20	CD
cord-006860-a3b8hyyr	1757	6	%	%	NN
cord-006860-a3b8hyyr	1757	7	(	(	-LRB-
cord-006860-a3b8hyyr	1757	8	lS-23	ls-23	UH
cord-006860-a3b8hyyr	1757	9	)	)	-RRB-
cord-006860-a3b8hyyr	1757	10	of	of	IN
cord-006860-a3b8hyyr	1757	11	CF[B.	CF[B.	NNP
cord-006860-a3b8hyyr	1758	1	When	when	WRB
cord-006860-a3b8hyyr	1758	2	the	the	DT
cord-006860-a3b8hyyr	1758	3	patient	patient	NN
cord-006860-a3b8hyyr	1758	4	's	's	POS
cord-006860-a3b8hyyr	1758	5	plasma	plasma	NN
cord-006860-a3b8hyyr	1758	6	was	be	VBD
cord-006860-a3b8hyyr	1758	7	added	add	VBN
cord-006860-a3b8hyyr	1758	8	m	m	NNP
cord-006860-a3b8hyyr	1758	9	normal	normal	JJ
cord-006860-a3b8hyyr	1758	10	pooled	pooled	JJ
cord-006860-a3b8hyyr	1758	11	plasma	plasma	NN
cord-006860-a3b8hyyr	1758	12	it	-PRON-	PRP
cord-006860-a3b8hyyr	1758	13	caused	cause	VBD
cord-006860-a3b8hyyr	1758	14	,	,	,
cord-006860-a3b8hyyr	1758	15	in	in	IN
cord-006860-a3b8hyyr	1758	16	a	a	DT
cord-006860-a3b8hyyr	1758	17	dose	dose	NN
cord-006860-a3b8hyyr	1758	18	-	-	HYPH
cord-006860-a3b8hyyr	1758	19	dependent	dependent	JJ
cord-006860-a3b8hyyr	1758	20	manner	manner	NN
cord-006860-a3b8hyyr	1758	21	,	,	,
cord-006860-a3b8hyyr	1758	22	values	value	NNS
cord-006860-a3b8hyyr	1758	23	lower	lower	RBR
cord-006860-a3b8hyyr	1758	24	than	than	IN
cord-006860-a3b8hyyr	1758	25	predicted	predict	VBN
cord-006860-a3b8hyyr	1758	26	for	for	IN
cord-006860-a3b8hyyr	1758	27	DFIB	DFIB	NNS
cord-006860-a3b8hyyr	1758	28	and	and	CC
cord-006860-a3b8hyyr	1758	29	values	value	NNS
cord-006860-a3b8hyyr	1758	30	slightly	slightly	RB
cord-006860-a3b8hyyr	1758	31	higher	high	JJR
cord-006860-a3b8hyyr	1758	32	than	than	IN
cord-006860-a3b8hyyr	1758	33	predicted	predict	VBN
cord-006860-a3b8hyyr	1758	34	for	for	IN
cord-006860-a3b8hyyr	1758	35	CFIB	CFIB	NNP
cord-006860-a3b8hyyr	1758	36	.	.	.
cord-006860-a3b8hyyr	1759	1	In	in	IN
cord-006860-a3b8hyyr	1759	2	the	the	DT
cord-006860-a3b8hyyr	1759	3	absence	absence	NN
cord-006860-a3b8hyyr	1759	4	of	of	IN
cord-006860-a3b8hyyr	1759	5	data	datum	NNS
cord-006860-a3b8hyyr	1759	6	from	from	IN
cord-006860-a3b8hyyr	1759	7	additional	additional	JJ
cord-006860-a3b8hyyr	1759	8	(	(	-LRB-
cord-006860-a3b8hyyr	1759	9	e.g.	e.g.	IN
cord-006860-a3b8hyyr	1759	10	immunologic	immunologic	JJ
cord-006860-a3b8hyyr	1759	11	)	)	-RRB-
cord-006860-a3b8hyyr	1759	12	methods	method	NNS
cord-006860-a3b8hyyr	1759	13	the	the	DT
cord-006860-a3b8hyyr	1759	14	following	follow	VBG
cord-006860-a3b8hyyr	1759	15	principal	principal	JJ
cord-006860-a3b8hyyr	1759	16	possibilities	possibility	NNS
cord-006860-a3b8hyyr	1759	17	(	(	-LRB-
cord-006860-a3b8hyyr	1759	18	and	and	CC
cord-006860-a3b8hyyr	1759	19	combinations	combination	NNS
cord-006860-a3b8hyyr	1759	20	)	)	-RRB-
cord-006860-a3b8hyyr	1759	21	have	have	VBP
cord-006860-a3b8hyyr	1759	22	to	to	TO
cord-006860-a3b8hyyr	1759	23	be	be	VB
cord-006860-a3b8hyyr	1759	24	considered	consider	VBN
cord-006860-a3b8hyyr	1759	25	:	:	:
cord-006860-a3b8hyyr	1759	26	1	1	LS
cord-006860-a3b8hyyr	1759	27	)	)	-RRB-
cord-006860-a3b8hyyr	1759	28	normal	normal	JJ
cord-006860-a3b8hyyr	1759	29	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1759	30	concentration	concentration	NN
cord-006860-a3b8hyyr	1759	31	and	and	CC
cord-006860-a3b8hyyr	1759	32	clot	clot	NN
cord-006860-a3b8hyyr	1759	33	formation	formation	NN
cord-006860-a3b8hyyr	1759	34	rate	rate	NN
cord-006860-a3b8hyyr	1759	35	,	,	,
cord-006860-a3b8hyyr	1759	36	but	but	CC
cord-006860-a3b8hyyr	1759	37	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	1759	38	optical	optical	JJ
cord-006860-a3b8hyyr	1759	39	properties	property	NNS
cord-006860-a3b8hyyr	1759	40	of	of	IN
cord-006860-a3b8hyyr	1759	41	the	the	DT
cord-006860-a3b8hyyr	1759	42	clot	clot	NN
cord-006860-a3b8hyyr	1759	43	(	(	-LRB-
cord-006860-a3b8hyyr	1759	44	CFIB	CFIB	NNP
cord-006860-a3b8hyyr	1759	45	correct	correct	JJ
cord-006860-a3b8hyyr	1759	46	,	,	,
cord-006860-a3b8hyyr	1759	47	DFIB	DFIB	NNP
cord-006860-a3b8hyyr	1759	48	falsely	falsely	RB
cord-006860-a3b8hyyr	1759	49	tow	tow	VBD
cord-006860-a3b8hyyr	1759	50	)	)	-RRB-
cord-006860-a3b8hyyr	1759	51	;	;	:
cord-006860-a3b8hyyr	1759	52	2	2	LS
cord-006860-a3b8hyyr	1759	53	)	)	-RRB-
cord-006860-a3b8hyyr	1759	54	normal	normal	JJ
cord-006860-a3b8hyyr	1759	55	optical	optical	JJ
cord-006860-a3b8hyyr	1759	56	properties	property	NNS
cord-006860-a3b8hyyr	1759	57	of	of	IN
cord-006860-a3b8hyyr	1759	58	the	the	DT
cord-006860-a3b8hyyr	1759	59	clot	clot	NN
cord-006860-a3b8hyyr	1759	60	,	,	,
cord-006860-a3b8hyyr	1759	61	but	but	CC
cord-006860-a3b8hyyr	1759	62	accelerated	accelerated	JJ
cord-006860-a3b8hyyr	1759	63	clot	clot	NN
cord-006860-a3b8hyyr	1759	64	formation	formation	NN
cord-006860-a3b8hyyr	1759	65	and	and	CC
cord-006860-a3b8hyyr	1759	66	very	very	RB
cord-006860-a3b8hyyr	1759	67	low	low	JJ
cord-006860-a3b8hyyr	1759	68	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1759	69	concentration	concentration	NN
cord-006860-a3b8hyyr	1759	70	(	(	-LRB-
cord-006860-a3b8hyyr	1759	71	DFIB	DFIB	NNP
cord-006860-a3b8hyyr	1759	72	correct	correct	JJ
cord-006860-a3b8hyyr	1759	73	,	,	,
cord-006860-a3b8hyyr	1759	74	CFIB	CFIB	NNP
cord-006860-a3b8hyyr	1759	75	falsely	falsely	RB
cord-006860-a3b8hyyr	1759	76	high	high	JJ
cord-006860-a3b8hyyr	1759	77	)	)	-RRB-
cord-006860-a3b8hyyr	1759	78	.	.	.
cord-006860-a3b8hyyr	1760	1	In	in	IN
cord-006860-a3b8hyyr	1760	2	either	either	DT
cord-006860-a3b8hyyr	1760	3	case	case	NN
cord-006860-a3b8hyyr	1760	4	,	,	,
cord-006860-a3b8hyyr	1760	5	the	the	DT
cord-006860-a3b8hyyr	1760	6	molecular	molecular	JJ
cord-006860-a3b8hyyr	1760	7	basis	basis	NN
cord-006860-a3b8hyyr	1760	8	could	could	MD
cord-006860-a3b8hyyr	1760	9	be	be	VB
cord-006860-a3b8hyyr	1760	10	:	:	:
cord-006860-a3b8hyyr	1760	11	A	a	LS
cord-006860-a3b8hyyr	1760	12	)	)	-RRB-
cord-006860-a3b8hyyr	1760	13	a	a	DT
cord-006860-a3b8hyyr	1760	14	genetic	genetic	JJ
cord-006860-a3b8hyyr	1760	15	or	or	CC
cord-006860-a3b8hyyr	1760	16	acquired	acquire	VBN
cord-006860-a3b8hyyr	1760	17	molecular	molecular	JJ
cord-006860-a3b8hyyr	1760	18	abnnrmality	abnnrmality	NN
cord-006860-a3b8hyyr	1760	19	of	of	IN
cord-006860-a3b8hyyr	1760	20	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1760	21	/	/	SYM
cord-006860-a3b8hyyr	1760	22	fibfinogen	fibfinogen	NN
cord-006860-a3b8hyyr	1760	23	;	;	:
cord-006860-a3b8hyyr	1760	24	B	b	NN
cord-006860-a3b8hyyr	1760	25	)	)	-RRB-
cord-006860-a3b8hyyr	1760	26	an	an	DT
cord-006860-a3b8hyyr	1760	27	interfering	interfere	VBG
cord-006860-a3b8hyyr	1760	28	substance	substance	NN
cord-006860-a3b8hyyr	1760	29	.	.	.
cord-006860-a3b8hyyr	1761	1	Direct	direct	JJ
cord-006860-a3b8hyyr	1761	2	effects	effect	NNS
cord-006860-a3b8hyyr	1761	3	of	of	IN
cord-006860-a3b8hyyr	1761	4	the	the	DT
cord-006860-a3b8hyyr	1761	5	loxic	loxic	NNP
cord-006860-a3b8hyyr	1761	6	agent	agent	NN
cord-006860-a3b8hyyr	1761	7	parathion	parathion	NNP
cord-006860-a3b8hyyr	1761	8	and/or	and/or	CC
cord-006860-a3b8hyyr	1761	9	the	the	DT
cord-006860-a3b8hyyr	1761	10	antidot	antidot	NNP
cord-006860-a3b8hyyr	1761	11	drug	drug	NN
cord-006860-a3b8hyyr	1761	12	atropin	atropin	NNP
cord-006860-a3b8hyyr	1761	13	are	be	VBP
cord-006860-a3b8hyyr	1761	14	not	not	RB
cord-006860-a3b8hyyr	1761	15	likely	likely	JJ
cord-006860-a3b8hyyr	1761	16	to	to	TO
cord-006860-a3b8hyyr	1761	17	be	be	VB
cord-006860-a3b8hyyr	1761	18	the	the	DT
cord-006860-a3b8hyyr	1761	19	cause	cause	NN
cord-006860-a3b8hyyr	1761	20	since	since	IN
cord-006860-a3b8hyyr	1761	21	other	other	JJ
cord-006860-a3b8hyyr	1761	22	patients	patient	NNS
cord-006860-a3b8hyyr	1761	23	,	,	,
cord-006860-a3b8hyyr	1761	24	often	often	RB
cord-006860-a3b8hyyr	1761	25	with	with	IN
cord-006860-a3b8hyyr	1761	26	more	more	RBR
cord-006860-a3b8hyyr	1761	27	severe	severe	JJ
cord-006860-a3b8hyyr	1761	28	parathion	parathion	NN
cord-006860-a3b8hyyr	1761	29	inmxicatian	inmxicatian	IN
cord-006860-a3b8hyyr	1761	30	requiring	require	VBG
cord-006860-a3b8hyyr	1761	31	higher	high	JJR
cord-006860-a3b8hyyr	1761	32	doses	dose	NNS
cord-006860-a3b8hyyr	1761	33	of	of	IN
cord-006860-a3b8hyyr	1761	34	atmpin	atmpin	NNP
cord-006860-a3b8hyyr	1761	35	,	,	,
cord-006860-a3b8hyyr	1761	36	showed	show	VBD
cord-006860-a3b8hyyr	1761	37	normal	normal	JJ
cord-006860-a3b8hyyr	1761	38	optical	optical	JJ
cord-006860-a3b8hyyr	1761	39	density	density	NN
cord-006860-a3b8hyyr	1761	40	of	of	IN
cord-006860-a3b8hyyr	1761	41	the	the	DT
cord-006860-a3b8hyyr	1761	42	clot	clot	NN
cord-006860-a3b8hyyr	1761	43	.	.	.
cord-006860-a3b8hyyr	1762	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1762	2	hope	hope	VBP
cord-006860-a3b8hyyr	1762	3	to	to	TO
cord-006860-a3b8hyyr	1762	4	perform	perform	VB
cord-006860-a3b8hyyr	1762	5	a	a	DT
cord-006860-a3b8hyyr	1762	6	more	more	RBR
cord-006860-a3b8hyyr	1762	7	in	in	IN
cord-006860-a3b8hyyr	1762	8	depth	depth	NN
cord-006860-a3b8hyyr	1762	9	investigation	investigation	NN
cord-006860-a3b8hyyr	1762	10	of	of	IN
cord-006860-a3b8hyyr	1762	11	this	this	DT
cord-006860-a3b8hyyr	1762	12	abnormality	abnormality	NN
cord-006860-a3b8hyyr	1762	13	in	in	IN
cord-006860-a3b8hyyr	1762	14	the	the	DT
cord-006860-a3b8hyyr	1762	15	future	future	NN
cord-006860-a3b8hyyr	1762	16	,	,	,
cord-006860-a3b8hyyr	1762	17	including	include	VBG
cord-006860-a3b8hyyr	1762	18	various	various	JJ
cord-006860-a3b8hyyr	1762	19	methods	method	NNS
cord-006860-a3b8hyyr	1762	20	,	,	,
cord-006860-a3b8hyyr	1762	21	reagents	reagent	NNS
cord-006860-a3b8hyyr	1762	22	,	,	,
cord-006860-a3b8hyyr	1762	23	and	and	CC
cord-006860-a3b8hyyr	1762	24	instruments	instrument	NNS
cord-006860-a3b8hyyr	1762	25	for	for	IN
cord-006860-a3b8hyyr	1762	26	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1762	27	measurement	measurement	NN
cord-006860-a3b8hyyr	1762	28	,	,	,
cord-006860-a3b8hyyr	1762	29	a	a	DT
cord-006860-a3b8hyyr	1762	30	survey	survey	NN
cord-006860-a3b8hyyr	1762	31	of	of	IN
cord-006860-a3b8hyyr	1762	32	the	the	DT
cord-006860-a3b8hyyr	1762	33	patient	patient	NN
cord-006860-a3b8hyyr	1762	34	"	"	``
cord-006860-a3b8hyyr	1762	35	s	s	NNS
cord-006860-a3b8hyyr	1762	36	family	family	NN
cord-006860-a3b8hyyr	1762	37	,	,	,
cord-006860-a3b8hyyr	1762	38	and	and	CC
cord-006860-a3b8hyyr	1762	39	studies	study	NNS
cord-006860-a3b8hyyr	1762	40	of	of	IN
cord-006860-a3b8hyyr	1762	41	the	the	DT
cord-006860-a3b8hyyr	1762	42	molecular	molecular	JJ
cord-006860-a3b8hyyr	1762	43	nature	nature	NN
cord-006860-a3b8hyyr	1762	44	of	of	IN
cord-006860-a3b8hyyr	1762	45	the	the	DT
cord-006860-a3b8hyyr	1762	46	phenomenon	phenomenon	NN
cord-006860-a3b8hyyr	1762	47	.	.	.
cord-006860-a3b8hyyr	1763	1	Increased	increase	VBN
cord-006860-a3b8hyyr	1763	2	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1763	3	is	be	VBZ
cord-006860-a3b8hyyr	1763	4	known	know	VBN
cord-006860-a3b8hyyr	1763	5	to	to	TO
cord-006860-a3b8hyyr	1763	6	be	be	VB
cord-006860-a3b8hyyr	1763	7	an	an	DT
cord-006860-a3b8hyyr	1763	8	independent	independent	JJ
cord-006860-a3b8hyyr	1763	9	predictor	predictor	NN
cord-006860-a3b8hyyr	1763	10	of	of	IN
cord-006860-a3b8hyyr	1763	11	subseqtmnt	subseqtmnt	NNP
cord-006860-a3b8hyyr	1763	12	acut~	acut~	IN
cord-006860-a3b8hyyr	1763	13	coronary	coronary	JJ
cord-006860-a3b8hyyr	1763	14	syndromes	syndrome	NNS
cord-006860-a3b8hyyr	1763	15	.	.	.
cord-006860-a3b8hyyr	1764	1	However	however	RB
cord-006860-a3b8hyyr	1764	2	.	.	.
cord-006860-a3b8hyyr	1765	1	a	a	DT
cord-006860-a3b8hyyr	1765	2	multitude	multitude	NN
cord-006860-a3b8hyyr	1765	3	of	of	IN
cord-006860-a3b8hyyr	1765	4	methods	method	NNS
cord-006860-a3b8hyyr	1765	5	for	for	IN
cord-006860-a3b8hyyr	1765	6	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1765	7	determination	determination	NN
cord-006860-a3b8hyyr	1765	8	is	be	VBZ
cord-006860-a3b8hyyr	1765	9	available	available	JJ
cord-006860-a3b8hyyr	1765	10	.	.	.
cord-006860-a3b8hyyr	1766	1	There	there	EX
cord-006860-a3b8hyyr	1766	2	is	be	VBZ
cord-006860-a3b8hyyr	1766	3	a	a	DT
cord-006860-a3b8hyyr	1766	4	lack	lack	NN
cord-006860-a3b8hyyr	1766	5	of	of	IN
cord-006860-a3b8hyyr	1766	6	standardisation	standardisation	NN
cord-006860-a3b8hyyr	1766	7	among	among	IN
cord-006860-a3b8hyyr	1766	8	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1766	9	assays	assay	NNS
cord-006860-a3b8hyyr	1766	10	.	.	.
cord-006860-a3b8hyyr	1767	1	In	in	IN
cord-006860-a3b8hyyr	1767	2	a	a	DT
cord-006860-a3b8hyyr	1767	3	family	family	NN
cord-006860-a3b8hyyr	1767	4	cohort	cohort	NN
cord-006860-a3b8hyyr	1767	5	study	study	NN
cord-006860-a3b8hyyr	1767	6	(	(	-LRB-
cord-006860-a3b8hyyr	1767	7	patients'with	patients'with	NNP
cord-006860-a3b8hyyr	1767	8	combined	combine	VBN
cord-006860-a3b8hyyr	1767	9	hyperlipidaemia	hyperlipidaemia	NN
cord-006860-a3b8hyyr	1767	10	and	and	CC
cord-006860-a3b8hyyr	1767	11	f	f	NNP
cord-006860-a3b8hyyr	1767	12	or	or	CC
cord-006860-a3b8hyyr	1767	13	hypemricaemia	hypemricaemia	NNP
cord-006860-a3b8hyyr	1767	14	)	)	-RRB-
cord-006860-a3b8hyyr	1767	15	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1767	16	was	be	VBD
cord-006860-a3b8hyyr	1767	17	determined	determine	VBN
cord-006860-a3b8hyyr	1767	18	in	in	IN
cord-006860-a3b8hyyr	1767	19	plasma	plasma	NN
cord-006860-a3b8hyyr	1767	20	samples	sample	NNS
cord-006860-a3b8hyyr	1767	21	from	from	IN
cord-006860-a3b8hyyr	1767	22	340	340	CD
cord-006860-a3b8hyyr	1767	23	family	family	NN
cord-006860-a3b8hyyr	1767	24	members	member	NNS
cord-006860-a3b8hyyr	1767	25	using	use	VBG
cord-006860-a3b8hyyr	1767	26	a	a	DT
cord-006860-a3b8hyyr	1767	27	functional	functional	JJ
cord-006860-a3b8hyyr	1767	28	and	and	CC
cord-006860-a3b8hyyr	1767	29	an	an	DT
cord-006860-a3b8hyyr	1767	30	immunochemical	immunochemical	JJ
cord-006860-a3b8hyyr	1767	31	assay	assay	NN
cord-006860-a3b8hyyr	1767	32	.	.	.
cord-006860-a3b8hyyr	1768	1	The	the	DT
cord-006860-a3b8hyyr	1768	2	fimctional	fimctional	JJ
cord-006860-a3b8hyyr	1768	3	assay	assay	NN
cord-006860-a3b8hyyr	1768	4	according	accord	VBG
cord-006860-a3b8hyyr	1768	5	to	to	IN
cord-006860-a3b8hyyr	1768	6	Clauss	Clauss	NNP
cord-006860-a3b8hyyr	1768	7	was	be	VBD
cord-006860-a3b8hyyr	1768	8	performed	perform	VBN
cord-006860-a3b8hyyr	1768	9	on	on	IN
cord-006860-a3b8hyyr	1768	10	the	the	DT
cord-006860-a3b8hyyr	1768	11	analyser	analyser	NN
cord-006860-a3b8hyyr	1768	12	CA	CA	NNP
cord-006860-a3b8hyyr	1768	13	5000	5000	CD
cord-006860-a3b8hyyr	1768	14	using	use	VBG
cord-006860-a3b8hyyr	1768	15	the	the	DT
cord-006860-a3b8hyyr	1768	16	test	test	NN
cord-006860-a3b8hyyr	1768	17	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1768	18	a	a	DT
cord-006860-a3b8hyyr	1768	19	from	from	IN
cord-006860-a3b8hyyr	1768	20	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	1768	21	.	.	.
cord-006860-a3b8hyyr	1769	1	The	the	DT
cord-006860-a3b8hyyr	1769	2	immmmephelometric	immmmephelometric	JJ
cord-006860-a3b8hyyr	1769	3	assay	assay	NN
cord-006860-a3b8hyyr	1769	4	was	be	VBD
cord-006860-a3b8hyyr	1769	5	performed	perform	VBN
cord-006860-a3b8hyyr	1769	6	on	on	IN
cord-006860-a3b8hyyr	1769	7	~e	~e	NNP
cord-006860-a3b8hyyr	1769	8	Behring	Behring	NNP
cord-006860-a3b8hyyr	1769	9	Nephelometer	Nephelometer	NNP
cord-006860-a3b8hyyr	1769	10	System	System	NNP
cord-006860-a3b8hyyr	1769	11	using	use	VBG
cord-006860-a3b8hyyr	1769	12	the	the	DT
cord-006860-a3b8hyyr	1769	13	reagent	reagent	NN
cord-006860-a3b8hyyr	1769	14	and	and	CC
cord-006860-a3b8hyyr	1769	15	standard	standard	NN
cord-006860-a3b8hyyr	1769	16	from	from	IN
cord-006860-a3b8hyyr	1769	17	Behring	Behring	NNP
cord-006860-a3b8hyyr	1769	18	.	.	.
cord-006860-a3b8hyyr	1770	1	A	a	DT
cord-006860-a3b8hyyr	1770	2	good	good	JJ
cord-006860-a3b8hyyr	1770	3	similarity	similarity	NN
cord-006860-a3b8hyyr	1770	4	between	between	IN
cord-006860-a3b8hyyr	1770	5	both	both	DT
cord-006860-a3b8hyyr	1770	6	assays	assay	NNS
cord-006860-a3b8hyyr	1770	7	was	be	VBD
cord-006860-a3b8hyyr	1770	8	obtained	obtain	VBN
cord-006860-a3b8hyyr	1770	9	at	at	IN
cord-006860-a3b8hyyr	1770	10	low	low	JJ
cord-006860-a3b8hyyr	1770	11	and	and	CC
cord-006860-a3b8hyyr	1770	12	high	high	JJ
cord-006860-a3b8hyyr	1770	13	flbrinogen	flbrinogen	NN
cord-006860-a3b8hyyr	1770	14	levels	level	NNS
cord-006860-a3b8hyyr	1770	15	as	as	RB
cord-006860-a3b8hyyr	1770	16	well	well	RB
cord-006860-a3b8hyyr	1770	17	as	as	IN
cord-006860-a3b8hyyr	1770	18	in	in	IN
cord-006860-a3b8hyyr	1770	19	samples	sample	NNS
cord-006860-a3b8hyyr	1770	20	with	with	IN
cord-006860-a3b8hyyr	1770	21	increased	increase	VBN
cord-006860-a3b8hyyr	1770	22	C	c	NN
cord-006860-a3b8hyyr	1770	23	-	-	HYPH
cord-006860-a3b8hyyr	1770	24	reactive	reactive	JJ
cord-006860-a3b8hyyr	1770	25	protein	protein	NN
cord-006860-a3b8hyyr	1770	26	(	(	-LRB-
cord-006860-a3b8hyyr	1770	27	CRP	CRP	NNP
cord-006860-a3b8hyyr	1770	28	)	)	-RRB-
cord-006860-a3b8hyyr	1770	29	.	.	.
cord-006860-a3b8hyyr	1771	1	Values	value	NNS
cord-006860-a3b8hyyr	1771	2	obtained	obtain	VBN
cord-006860-a3b8hyyr	1771	3	by	by	IN
cord-006860-a3b8hyyr	1771	4	both	both	DT
cord-006860-a3b8hyyr	1771	5	assays	assay	NNS
cord-006860-a3b8hyyr	1771	6	correlated	correlate	VBD
cord-006860-a3b8hyyr	1771	7	similar	similar	JJ
cord-006860-a3b8hyyr	1771	8	with	with	IN
cord-006860-a3b8hyyr	1771	9	total	total	JJ
cord-006860-a3b8hyyr	1771	10	cholesterol	cholesterol	NN
cord-006860-a3b8hyyr	1771	11	,	,	,
cord-006860-a3b8hyyr	1771	12	LDL	ldl	NN
cord-006860-a3b8hyyr	1771	13	--	--	:
cord-006860-a3b8hyyr	1771	14	cbelesterol	cbelesterol	NNP
cord-006860-a3b8hyyr	1771	15	and	and	CC
cord-006860-a3b8hyyr	1771	16	apolipeprntein	apolipeprntein	NNP
cord-006860-a3b8hyyr	1772	1	B.	B.	NNP
cord-006860-a3b8hyyr	1773	1	The	the	DT
cord-006860-a3b8hyyr	1774	1	ratio	ratio	NNP
cord-006860-a3b8hyyr	1774	2	functional	functional	JJ
cord-006860-a3b8hyyr	1774	3	fibrinagen	fibrinagen	NN
cord-006860-a3b8hyyr	1774	4	/	/	SYM
cord-006860-a3b8hyyr	1774	5	immlmochemial	immlmochemial	JJ
cord-006860-a3b8hyyr	1774	6	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1774	7	showed	show	VBD
cord-006860-a3b8hyyr	1774	8	no	no	DT
cord-006860-a3b8hyyr	1774	9	dependence	dependence	NN
cord-006860-a3b8hyyr	1774	10	on	on	IN
cord-006860-a3b8hyyr	1774	11	cholesterol	cholesterol	NN
cord-006860-a3b8hyyr	1774	12	,	,	,
cord-006860-a3b8hyyr	1774	13	t	t	NNP
cord-006860-a3b8hyyr	1774	14	-	-	HYPH
cord-006860-a3b8hyyr	1774	15	PA	PA	NNP
cord-006860-a3b8hyyr	1774	16	,	,	,
cord-006860-a3b8hyyr	1774	17	v	v	NN
cord-006860-a3b8hyyr	1774	18	WiUebrand	WiUebrand	NNP
cord-006860-a3b8hyyr	1774	19	factor	factor	NN
cord-006860-a3b8hyyr	1774	20	and	and	CC
cord-006860-a3b8hyyr	1774	21	CRP	crp	NN
cord-006860-a3b8hyyr	1774	22	.	.	.
cord-006860-a3b8hyyr	1775	1	Release	Release	NNP
cord-006860-a3b8hyyr	1775	2	of	of	IN
cord-006860-a3b8hyyr	1775	3	two	two	CD
cord-006860-a3b8hyyr	1775	4	fibrinopeptides	fibrinopeptide	NNS
cord-006860-a3b8hyyr	1776	1	A	a	DT
cord-006860-a3b8hyyr	1776	2	from	from	IN
cord-006860-a3b8hyyr	1776	3	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1776	4	generates	generate	VBZ
cord-006860-a3b8hyyr	1776	5	DesAA	desaa	NN
cord-006860-a3b8hyyr	1776	6	-	-	HYPH
cord-006860-a3b8hyyr	1776	7	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1776	8	monomer	monomer	NN
cord-006860-a3b8hyyr	1776	9	,	,	,
cord-006860-a3b8hyyr	1776	10	which	which	WDT
cord-006860-a3b8hyyr	1776	11	rapidly	rapidly	RB
cord-006860-a3b8hyyr	1776	12	aggregates	aggregate	VBZ
cord-006860-a3b8hyyr	1776	13	,	,	,
cord-006860-a3b8hyyr	1776	14	forming	form	VBG
cord-006860-a3b8hyyr	1776	15	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1776	16	complexes	complex	NNS
cord-006860-a3b8hyyr	1776	17	.	.	.
cord-006860-a3b8hyyr	1777	1	Fibrin	fibrin	NN
cord-006860-a3b8hyyr	1777	2	monomers	monomer	NNS
cord-006860-a3b8hyyr	1777	3	can	can	MD
cord-006860-a3b8hyyr	1777	4	be	be	VB
cord-006860-a3b8hyyr	1777	5	detected	detect	VBN
cord-006860-a3b8hyyr	1777	6	in	in	IN
cord-006860-a3b8hyyr	1777	7	plasma	plasma	NN
cord-006860-a3b8hyyr	1777	8	samples	sample	NNS
cord-006860-a3b8hyyr	1777	9	after	after	IN
cord-006860-a3b8hyyr	1777	10	chemical	chemical	JJ
cord-006860-a3b8hyyr	1777	11	desaggregation	desaggregation	NN
cord-006860-a3b8hyyr	1777	12	of	of	IN
cord-006860-a3b8hyyr	1777	13	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1777	14	complexes	complex	NNS
cord-006860-a3b8hyyr	1777	15	using	use	VBG
cord-006860-a3b8hyyr	1777	16	thiocyanate	thiocyanate	NN
cord-006860-a3b8hyyr	1777	17	by	by	IN
cord-006860-a3b8hyyr	1777	18	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	1777	19	antibody	antibody	NN
cord-006860-a3b8hyyr	1777	20	binding	bind	VBG
cord-006860-a3b8hyyr	1777	21	to	to	IN
cord-006860-a3b8hyyr	1777	22	the	the	DT
cord-006860-a3b8hyyr	1777	23	alpha	alpha	NN
cord-006860-a3b8hyyr	1777	24	-	-	HYPH
cord-006860-a3b8hyyr	1777	25	chain	chain	NN
cord-006860-a3b8hyyr	1777	26	Neo	Neo	NNP
cord-006860-a3b8hyyr	1777	27	-	-	HYPH
cord-006860-a3b8hyyr	1777	28	N	N	NNP
cord-006860-a3b8hyyr	1777	29	-	-	HYPH
cord-006860-a3b8hyyr	1777	30	termini	termini	NNP
cord-006860-a3b8hyyr	1777	31	generated	generate	VBN
cord-006860-a3b8hyyr	1777	32	by	by	IN
cord-006860-a3b8hyyr	1777	33	fibrinopeptide	fibrinopeptide	NN
cord-006860-a3b8hyyr	1777	34	release	release	NN
cord-006860-a3b8hyyr	1777	35	.	.	.
cord-006860-a3b8hyyr	1778	1	Although	although	IN
cord-006860-a3b8hyyr	1778	2	postulated	postulate	VBN
cord-006860-a3b8hyyr	1778	3	,	,	,
cord-006860-a3b8hyyr	1778	4	an	an	DT
cord-006860-a3b8hyyr	1778	5	intermediate	intermediate	NN
cord-006860-a3b8hyyr	1778	6	of	of	IN
cord-006860-a3b8hyyr	1778	7	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1778	8	formation	formation	NN
cord-006860-a3b8hyyr	1778	9	,	,	,
cord-006860-a3b8hyyr	1778	10	carrying	carry	VBG
cord-006860-a3b8hyyr	1778	11	one	one	CD
cord-006860-a3b8hyyr	1778	12	fibrinopeptide	fibrinopeptide	NN
cord-006860-a3b8hyyr	1778	13	A	a	NN
cord-006860-a3b8hyyr	1778	14	and	and	CC
cord-006860-a3b8hyyr	1778	15	one	one	CD
cord-006860-a3b8hyyr	1778	16	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1778	17	alpha	alpha	NN
cord-006860-a3b8hyyr	1778	18	-	-	HYPH
cord-006860-a3b8hyyr	1778	19	chain	chain	NN
cord-006860-a3b8hyyr	1778	20	Neo	Neo	NNP
cord-006860-a3b8hyyr	1778	21	-	-	HYPH
cord-006860-a3b8hyyr	1778	22	N	N	NNP
cord-006860-a3b8hyyr	1778	23	-	-	HYPH
cord-006860-a3b8hyyr	1778	24	terminus	terminus	NN
cord-006860-a3b8hyyr	1778	25	has	have	VBZ
cord-006860-a3b8hyyr	1778	26	so	so	RB
cord-006860-a3b8hyyr	1778	27	far	far	RB
cord-006860-a3b8hyyr	1778	28	escaped	escape	VBN
cord-006860-a3b8hyyr	1778	29	analytical	analytical	JJ
cord-006860-a3b8hyyr	1778	30	procedures	procedure	NNS
cord-006860-a3b8hyyr	1778	31	.	.	.
cord-006860-a3b8hyyr	1779	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1779	2	have	have	VBP
cord-006860-a3b8hyyr	1779	3	employed	employ	VBN
cord-006860-a3b8hyyr	1779	4	a	a	DT
cord-006860-a3b8hyyr	1779	5	monoctonal	monoctonal	JJ
cord-006860-a3b8hyyr	1779	6	antibody	antibody	NN
cord-006860-a3b8hyyr	1779	7	specific	specific	JJ
cord-006860-a3b8hyyr	1779	8	for	for	IN
cord-006860-a3b8hyyr	1779	9	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1779	10	alpha	alpha	NN
cord-006860-a3b8hyyr	1779	11	-	-	HYPH
cord-006860-a3b8hyyr	1779	12	chain	chain	NN
cord-006860-a3b8hyyr	1779	13	neo	neo	NNP
cord-006860-a3b8hyyr	1779	14	-	-	HYPH
cord-006860-a3b8hyyr	1779	15	N	N	NNP
cord-006860-a3b8hyyr	1779	16	-	-	HYPH
cord-006860-a3b8hyyr	1779	17	terminus	terminus	NN
cord-006860-a3b8hyyr	1779	18	,	,	,
cord-006860-a3b8hyyr	1779	19	MAb	MAb	NNPS
cord-006860-a3b8hyyr	1779	20	2B5	2b5	CD
cord-006860-a3b8hyyr	1779	21	,	,	,
cord-006860-a3b8hyyr	1779	22	attached	attach	VBN
cord-006860-a3b8hyyr	1779	23	to	to	IN
cord-006860-a3b8hyyr	1779	24	magnetic	magnetic	JJ
cord-006860-a3b8hyyr	1779	25	microparticles	microparticle	NNS
cord-006860-a3b8hyyr	1779	26	,	,	,
cord-006860-a3b8hyyr	1779	27	for	for	IN
cord-006860-a3b8hyyr	1779	28	isolation	isolation	NN
cord-006860-a3b8hyyr	1779	29	of	of	IN
cord-006860-a3b8hyyr	1779	30	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1779	31	-	-	HYPH
cord-006860-a3b8hyyr	1779	32	related	relate	VBN
cord-006860-a3b8hyyr	1779	33	material	material	NN
cord-006860-a3b8hyyr	1779	34	from	from	IN
cord-006860-a3b8hyyr	1779	35	plasma	plasma	NN
cord-006860-a3b8hyyr	1779	36	samples	sample	NNS
cord-006860-a3b8hyyr	1779	37	of	of	IN
cord-006860-a3b8hyyr	1779	38	patients	patient	NNS
cord-006860-a3b8hyyr	1779	39	with	with	IN
cord-006860-a3b8hyyr	1779	40	elevated	elevated	JJ
cord-006860-a3b8hyyr	1779	41	soluble	soluble	JJ
cord-006860-a3b8hyyr	1779	42	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1779	43	.	.	.
cord-006860-a3b8hyyr	1780	1	The	the	DT
cord-006860-a3b8hyyr	1780	2	material	material	NN
cord-006860-a3b8hyyr	1780	3	was	be	VBD
cord-006860-a3b8hyyr	1780	4	desorbed	desorb	VBN
cord-006860-a3b8hyyr	1780	5	by	by	IN
cord-006860-a3b8hyyr	1780	6	SDS	sds	NN
cord-006860-a3b8hyyr	1780	7	-	-	HYPH
cord-006860-a3b8hyyr	1780	8	urea	urea	NN
cord-006860-a3b8hyyr	1780	9	buffer	buffer	NN
cord-006860-a3b8hyyr	1780	10	and	and	CC
cord-006860-a3b8hyyr	1780	11	subjected	subject	VBN
cord-006860-a3b8hyyr	1780	12	to	to	IN
cord-006860-a3b8hyyr	1780	13	SDS	SDS	NNP
cord-006860-a3b8hyyr	1780	14	-	-	HYPH
cord-006860-a3b8hyyr	1780	15	PAGE	PAGE	NNP
cord-006860-a3b8hyyr	1780	16	and	and	CC
cord-006860-a3b8hyyr	1780	17	immunoblotting	immunoblotting	NN
cord-006860-a3b8hyyr	1780	18	.	.	.
cord-006860-a3b8hyyr	1781	1	Immunostaining	immunostaine	VBG
cord-006860-a3b8hyyr	1781	2	with	with	IN
cord-006860-a3b8hyyr	1781	3	panspecific	panspecific	NNP
cord-006860-a3b8hyyr	1781	4	anti	anti	JJ
cord-006860-a3b8hyyr	1781	5	-	-	JJ
cord-006860-a3b8hyyr	1781	6	fibrinogen	fibrinogen	JJ
cord-006860-a3b8hyyr	1781	7	and	and	CC
cord-006860-a3b8hyyr	1781	8	anti	anti	JJ
cord-006860-a3b8hyyr	1781	9	-	-	JJ
cord-006860-a3b8hyyr	1781	10	FDP	FDP	NNP
cord-006860-a3b8hyyr	1781	11	-	-	HYPH
cord-006860-a3b8hyyr	1781	12	E	E	NNP
cord-006860-a3b8hyyr	1781	13	antisera	antisera	NNP
cord-006860-a3b8hyyr	1781	14	showed	show	VBD
cord-006860-a3b8hyyr	1781	15	a	a	DT
cord-006860-a3b8hyyr	1781	16	range	range	NN
cord-006860-a3b8hyyr	1781	17	of	of	IN
cord-006860-a3b8hyyr	1781	18	bands	band	NNS
cord-006860-a3b8hyyr	1781	19	corresponding	correspond	VBG
cord-006860-a3b8hyyr	1781	20	to	to	IN
cord-006860-a3b8hyyr	1781	21	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1781	22	monomers	monomer	NNS
cord-006860-a3b8hyyr	1781	23	,	,	,
cord-006860-a3b8hyyr	1781	24	and	and	CC
cord-006860-a3b8hyyr	1781	25	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1781	26	derivatives	derivative	NNS
cord-006860-a3b8hyyr	1781	27	containing	contain	VBG
cord-006860-a3b8hyyr	1781	28	the	the	DT
cord-006860-a3b8hyyr	1781	29	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1781	30	E	e	NN
cord-006860-a3b8hyyr	1781	31	-	-	NN
cord-006860-a3b8hyyr	1781	32	domain	domain	NN
cord-006860-a3b8hyyr	1781	33	.	.	.
cord-006860-a3b8hyyr	1782	1	lmmunostaining	lmmunostaine	VBG
cord-006860-a3b8hyyr	1782	2	with	with	IN
cord-006860-a3b8hyyr	1782	3	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	1782	4	anti	anti	NN
cord-006860-a3b8hyyr	1782	5	-	-	JJ
cord-006860-a3b8hyyr	1782	6	fibrinopeptide	fibrinopeptide	RB
cord-006860-a3b8hyyr	1782	7	A	a	DT
cord-006860-a3b8hyyr	1782	8	antibody	antibody	NN
cord-006860-a3b8hyyr	1782	9	resulted	result	VBD
cord-006860-a3b8hyyr	1782	10	in	in	IN
cord-006860-a3b8hyyr	1782	11	a	a	DT
cord-006860-a3b8hyyr	1782	12	doublet	doublet	JJ
cord-006860-a3b8hyyr	1782	13	band	band	NN
cord-006860-a3b8hyyr	1782	14	corresponding	correspond	VBG
cord-006860-a3b8hyyr	1782	15	in	in	IN
cord-006860-a3b8hyyr	1782	16	size	size	NN
cord-006860-a3b8hyyr	1782	17	to	to	TO
cord-006860-a3b8hyyr	1782	18	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1782	19	monomer	monomer	NN
cord-006860-a3b8hyyr	1782	20	.	.	.
cord-006860-a3b8hyyr	1783	1	Similar	similar	JJ
cord-006860-a3b8hyyr	1783	2	results	result	NNS
cord-006860-a3b8hyyr	1783	3	were	be	VBD
cord-006860-a3b8hyyr	1783	4	obtained	obtain	VBN
cord-006860-a3b8hyyr	1783	5	with	with	IN
cord-006860-a3b8hyyr	1783	6	polyclonal	polyclonal	JJ
cord-006860-a3b8hyyr	1783	7	antisera	antisera	NN
cord-006860-a3b8hyyr	1783	8	against	against	IN
cord-006860-a3b8hyyr	1783	9	fibrinopeptide	fibrinopeptide	NN
cord-006860-a3b8hyyr	1783	10	A.	a.	NN
cord-006860-a3b8hyyr	1784	1	For	for	IN
cord-006860-a3b8hyyr	1784	2	a	a	DT
cord-006860-a3b8hyyr	1784	3	more	more	RBR
cord-006860-a3b8hyyr	1784	4	quantitative	quantitative	JJ
cord-006860-a3b8hyyr	1784	5	approach	approach	NN
cord-006860-a3b8hyyr	1784	6	,	,	,
cord-006860-a3b8hyyr	1784	7	desA	desa	JJ
cord-006860-a3b8hyyr	1784	8	-	-	HYPH
cord-006860-a3b8hyyr	1784	9	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1784	10	monomer	monomer	NN
cord-006860-a3b8hyyr	1784	11	was	be	VBD
cord-006860-a3b8hyyr	1784	12	detected	detect	VBN
cord-006860-a3b8hyyr	1784	13	by	by	IN
cord-006860-a3b8hyyr	1784	14	an	an	DT
cord-006860-a3b8hyyr	1784	15	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	1784	16	procedure	procedure	NN
cord-006860-a3b8hyyr	1784	17	using	use	VBG
cord-006860-a3b8hyyr	1784	18	MAb	MAb	NNS
cord-006860-a3b8hyyr	1784	19	2B5	2b5	CD
cord-006860-a3b8hyyr	1784	20	as	as	IN
cord-006860-a3b8hyyr	1784	21	capture	capture	NN
cord-006860-a3b8hyyr	1784	22	and	and	CC
cord-006860-a3b8hyyr	1784	23	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	1784	24	anti	anti	NN
cord-006860-a3b8hyyr	1784	25	-	-	NN
cord-006860-a3b8hyyr	1784	26	fibrinopeptide	fibrinopeptide	JJ
cord-006860-a3b8hyyr	1785	1	A	a	DT
cord-006860-a3b8hyyr	1785	2	antibody	antibody	NN
cord-006860-a3b8hyyr	1785	3	as	as	IN
cord-006860-a3b8hyyr	1785	4	tag	tag	NN
cord-006860-a3b8hyyr	1785	5	.	.	.
cord-006860-a3b8hyyr	1786	1	A	a	DT
cord-006860-a3b8hyyr	1786	2	sample	sample	NN
cord-006860-a3b8hyyr	1786	3	with	with	IN
cord-006860-a3b8hyyr	1786	4	extremely	extremely	RB
cord-006860-a3b8hyyr	1786	5	high	high	JJ
cord-006860-a3b8hyyr	1786	6	level	level	NN
cord-006860-a3b8hyyr	1786	7	of	of	IN
cord-006860-a3b8hyyr	1786	8	desAA	desaa	NN
cord-006860-a3b8hyyr	1786	9	-	-	HYPH
cord-006860-a3b8hyyr	1786	10	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1786	11	monomer	monomer	NN
cord-006860-a3b8hyyr	1786	12	,	,	,
cord-006860-a3b8hyyr	1786	13	determined	determine	VBN
cord-006860-a3b8hyyr	1786	14	by	by	IN
cord-006860-a3b8hyyr	1786	15	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	1786	16	(	(	-LRB-
cord-006860-a3b8hyyr	1786	17	Enzymun	Enzymun	NNP
cord-006860-a3b8hyyr	1786	18	®	®	POS
cord-006860-a3b8hyyr	1786	19	-Test	-Test	NNP
cord-006860-a3b8hyyr	1786	20	FM	FM	NNP
cord-006860-a3b8hyyr	1786	21	)	)	-RRB-
cord-006860-a3b8hyyr	1786	22	was	be	VBD
cord-006860-a3b8hyyr	1786	23	used	use	VBN
cord-006860-a3b8hyyr	1786	24	for	for	IN
cord-006860-a3b8hyyr	1786	25	calibration	calibration	NN
cord-006860-a3b8hyyr	1786	26	,	,	,
cord-006860-a3b8hyyr	1786	27	since	since	IN
cord-006860-a3b8hyyr	1786	28	reference	reference	NN
cord-006860-a3b8hyyr	1786	29	material	material	NN
cord-006860-a3b8hyyr	1786	30	is	be	VBZ
cord-006860-a3b8hyyr	1786	31	not	not	RB
cord-006860-a3b8hyyr	1786	32	available	available	JJ
cord-006860-a3b8hyyr	1786	33	.	.	.
cord-006860-a3b8hyyr	1787	1	A	a	DT
cord-006860-a3b8hyyr	1787	2	correlation	correlation	NN
cord-006860-a3b8hyyr	1787	3	of	of	IN
cord-006860-a3b8hyyr	1787	4	r	r	NN
cord-006860-a3b8hyyr	1788	1	=	=	SYM
cord-006860-a3b8hyyr	1788	2	O.g4	O.g4	NNP
cord-006860-a3b8hyyr	1788	3	was	be	VBD
cord-006860-a3b8hyyr	1788	4	found	find	VBN
cord-006860-a3b8hyyr	1788	5	between	between	IN
cord-006860-a3b8hyyr	1788	6	DesAA	desaa	NN
cord-006860-a3b8hyyr	1788	7	-	-	HYPH
cord-006860-a3b8hyyr	1788	8	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1788	9	monomer	monomer	NN
cord-006860-a3b8hyyr	1788	10	and	and	CC
cord-006860-a3b8hyyr	1788	11	relative	relative	JJ
cord-006860-a3b8hyyr	1788	12	DesA	DesA	NNP
cord-006860-a3b8hyyr	1788	13	-	-	HYPH
cord-006860-a3b8hyyr	1788	14	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1788	15	monomer	monomer	NN
cord-006860-a3b8hyyr	1788	16	levels	level	NNS
cord-006860-a3b8hyyr	1788	17	.	.	.
cord-006860-a3b8hyyr	1789	1	Detection	detection	NN
cord-006860-a3b8hyyr	1789	2	of	of	IN
cord-006860-a3b8hyyr	1789	3	DesA	DesA	NNP
cord-006860-a3b8hyyr	1789	4	-	-	HYPH
cord-006860-a3b8hyyr	1789	5	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1789	6	monomer	monomer	NN
cord-006860-a3b8hyyr	1789	7	required	require	VBD
cord-006860-a3b8hyyr	1789	8	sample	sample	NN
cord-006860-a3b8hyyr	1789	9	pretreatment	pretreatment	NN
cord-006860-a3b8hyyr	1789	10	with	with	IN
cord-006860-a3b8hyyr	1789	11	thiocyanate	thiocyanate	NN
cord-006860-a3b8hyyr	1789	12	for	for	IN
cord-006860-a3b8hyyr	1789	13	desaggregadon	desaggregadon	NN
cord-006860-a3b8hyyr	1789	14	of	of	IN
cord-006860-a3b8hyyr	1789	15	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1789	16	complexes	complex	NNS
cord-006860-a3b8hyyr	1789	17	.	.	.
cord-006860-a3b8hyyr	1790	1	From	from	IN
cord-006860-a3b8hyyr	1790	2	these	these	DT
cord-006860-a3b8hyyr	1790	3	preliminary	preliminary	JJ
cord-006860-a3b8hyyr	1790	4	data	datum	NNS
cord-006860-a3b8hyyr	1790	5	it	-PRON-	PRP
cord-006860-a3b8hyyr	1790	6	appears	appear	VBZ
cord-006860-a3b8hyyr	1790	7	that	that	IN
cord-006860-a3b8hyyr	1790	8	DesA	DesA	NNP
cord-006860-a3b8hyyr	1790	9	-	-	HYPH
cord-006860-a3b8hyyr	1790	10	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1790	11	monomer	monomer	NN
cord-006860-a3b8hyyr	1790	12	accounts	account	VBZ
cord-006860-a3b8hyyr	1790	13	for	for	IN
cord-006860-a3b8hyyr	1790	14	a	a	DT
cord-006860-a3b8hyyr	1790	15	fairly	fairly	RB
cord-006860-a3b8hyyr	1790	16	constant	constant	JJ
cord-006860-a3b8hyyr	1790	17	proportion	proportion	NN
cord-006860-a3b8hyyr	1790	18	of	of	IN
cord-006860-a3b8hyyr	1790	19	soluble	soluble	JJ
cord-006860-a3b8hyyr	1790	20	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1790	21	and	and	CC
cord-006860-a3b8hyyr	1790	22	is	be	VBZ
cord-006860-a3b8hyyr	1790	23	a	a	DT
cord-006860-a3b8hyyr	1790	24	polymerizing	polymerize	VBG
cord-006860-a3b8hyyr	1790	25	species	specie	NNS
cord-006860-a3b8hyyr	1790	26	.	.	.
cord-006860-a3b8hyyr	1791	1	Fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1791	2	has	have	VBZ
cord-006860-a3b8hyyr	1791	3	been	be	VBN
cord-006860-a3b8hyyr	1791	4	shown	show	VBN
cord-006860-a3b8hyyr	1791	5	to	to	TO
cord-006860-a3b8hyyr	1791	6	be	be	VB
cord-006860-a3b8hyyr	1791	7	a	a	DT
cord-006860-a3b8hyyr	1791	8	major	major	JJ
cord-006860-a3b8hyyr	1791	9	cardiovascular	cardiovascular	JJ
cord-006860-a3b8hyyr	1791	10	risk	risk	NN
cord-006860-a3b8hyyr	1791	11	factor	factor	NN
cord-006860-a3b8hyyr	1791	12	.	.	.
cord-006860-a3b8hyyr	1792	1	Especially	especially	RB
cord-006860-a3b8hyyr	1792	2	for	for	IN
cord-006860-a3b8hyyr	1792	3	epidemiological	epidemiological	JJ
cord-006860-a3b8hyyr	1792	4	studies	study	NNS
cord-006860-a3b8hyyr	1792	5	,	,	,
cord-006860-a3b8hyyr	1792	6	exact	exact	JJ
cord-006860-a3b8hyyr	1792	7	quantitation	quantitation	NN
cord-006860-a3b8hyyr	1792	8	of	of	IN
cord-006860-a3b8hyyr	1792	9	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1792	10	in	in	IN
cord-006860-a3b8hyyr	1792	11	clinical	clinical	JJ
cord-006860-a3b8hyyr	1792	12	plasma	plasma	NN
cord-006860-a3b8hyyr	1792	13	samples	sample	NNS
cord-006860-a3b8hyyr	1792	14	is	be	VBZ
cord-006860-a3b8hyyr	1792	15	of	of	IN
cord-006860-a3b8hyyr	1792	16	great	great	JJ
cord-006860-a3b8hyyr	1792	17	imporance	imporance	NN
cord-006860-a3b8hyyr	1792	18	.	.	.
cord-006860-a3b8hyyr	1793	1	Fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1793	2	levels	level	NNS
cord-006860-a3b8hyyr	1793	3	are	be	VBP
cord-006860-a3b8hyyr	1793	4	generally	generally	RB
cord-006860-a3b8hyyr	1793	5	measured	measure	VBN
cord-006860-a3b8hyyr	1793	6	by	by	IN
cord-006860-a3b8hyyr	1793	7	clotting	clot	VBG
cord-006860-a3b8hyyr	1793	8	assay	assay	NN
cord-006860-a3b8hyyr	1793	9	according	accord	VBG
cord-006860-a3b8hyyr	1793	10	to	to	IN
cord-006860-a3b8hyyr	1793	11	Clauss	Clauss	NNP
cord-006860-a3b8hyyr	1793	12	,	,	,
cord-006860-a3b8hyyr	1793	13	or	or	CC
cord-006860-a3b8hyyr	1793	14	by	by	IN
cord-006860-a3b8hyyr	1793	15	determination	determination	NN
cord-006860-a3b8hyyr	1793	16	of	of	IN
cord-006860-a3b8hyyr	1793	17	derived	derive	VBN
cord-006860-a3b8hyyr	1793	18	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1793	19	values	value	NNS
cord-006860-a3b8hyyr	1793	20	upon	upon	IN
cord-006860-a3b8hyyr	1793	21	photometric	photometric	JJ
cord-006860-a3b8hyyr	1793	22	measurement	measurement	NN
cord-006860-a3b8hyyr	1793	23	of	of	IN
cord-006860-a3b8hyyr	1793	24	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	1793	25	time	time	NN
cord-006860-a3b8hyyr	1793	26	(	(	-LRB-
cord-006860-a3b8hyyr	1793	27	derFbg	derFbg	NNP
cord-006860-a3b8hyyr	1793	28	)	)	-RRB-
cord-006860-a3b8hyyr	1793	29	.	.	.
cord-006860-a3b8hyyr	1794	1	The	the	DT
cord-006860-a3b8hyyr	1794	2	clotting	clotting	NN
cord-006860-a3b8hyyr	1794	3	assay	assay	NN
cord-006860-a3b8hyyr	1794	4	has	have	VBZ
cord-006860-a3b8hyyr	1794	5	been	be	VBN
cord-006860-a3b8hyyr	1794	6	shown	show	VBN
cord-006860-a3b8hyyr	1794	7	to	to	TO
cord-006860-a3b8hyyr	1794	8	be	be	VB
cord-006860-a3b8hyyr	1794	9	influenced	influence	VBN
cord-006860-a3b8hyyr	1794	10	by	by	IN
cord-006860-a3b8hyyr	1794	11	high	high	JJ
cord-006860-a3b8hyyr	1794	12	levels	level	NNS
cord-006860-a3b8hyyr	1794	13	of	of	IN
cord-006860-a3b8hyyr	1794	14	soluble	soluble	JJ
cord-006860-a3b8hyyr	1794	15	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1794	16	derivatives	derivative	NNS
cord-006860-a3b8hyyr	1794	17	.	.	.
cord-006860-a3b8hyyr	1795	1	The	the	DT
cord-006860-a3b8hyyr	1795	2	PT	pt	NN
cord-006860-a3b8hyyr	1795	3	-	-	HYPH
cord-006860-a3b8hyyr	1795	4	derived	derive	VBN
cord-006860-a3b8hyyr	1795	5	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1795	6	levels	level	NNS
cord-006860-a3b8hyyr	1795	7	appear	appear	VBP
cord-006860-a3b8hyyr	1795	8	rather	rather	RB
cord-006860-a3b8hyyr	1795	9	convenient	convenient	JJ
cord-006860-a3b8hyyr	1795	10	in	in	IN
cord-006860-a3b8hyyr	1795	11	clinical	clinical	JJ
cord-006860-a3b8hyyr	1795	12	routine	routine	NN
cord-006860-a3b8hyyr	1795	13	,	,	,
cord-006860-a3b8hyyr	1795	14	since	since	IN
cord-006860-a3b8hyyr	1795	15	no	no	DT
cord-006860-a3b8hyyr	1795	16	additional	additional	JJ
cord-006860-a3b8hyyr	1795	17	reagents	reagent	NNS
cord-006860-a3b8hyyr	1795	18	are	be	VBP
cord-006860-a3b8hyyr	1795	19	needed	need	VBN
cord-006860-a3b8hyyr	1795	20	.	.	.
cord-006860-a3b8hyyr	1796	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1796	2	have	have	VBP
cord-006860-a3b8hyyr	1796	3	compared	compare	VBN
cord-006860-a3b8hyyr	1796	4	the	the	DT
cord-006860-a3b8hyyr	1796	5	Clauss	Clauss	NNP
cord-006860-a3b8hyyr	1796	6	assay	assay	NN
cord-006860-a3b8hyyr	1796	7	and	and	CC
cord-006860-a3b8hyyr	1796	8	derFbg	derFbg	NNS
cord-006860-a3b8hyyr	1796	9	with	with	IN
cord-006860-a3b8hyyr	1796	10	a	a	DT
cord-006860-a3b8hyyr	1796	11	turbidimetric	turbidimetric	JJ
cord-006860-a3b8hyyr	1796	12	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1796	13	assay	assay	NN
cord-006860-a3b8hyyr	1796	14	using	use	VBG
cord-006860-a3b8hyyr	1796	15	snake	snake	NN
cord-006860-a3b8hyyr	1796	16	venom	venom	NN
cord-006860-a3b8hyyr	1796	17	protease	protease	NN
cord-006860-a3b8hyyr	1796	18	for	for	IN
cord-006860-a3b8hyyr	1796	19	fibrinopeptide	fibrinopeptide	NN
cord-006860-a3b8hyyr	1796	20	release	release	NN
cord-006860-a3b8hyyr	1796	21	,	,	,
cord-006860-a3b8hyyr	1796	22	performed	perform	VBN
cord-006860-a3b8hyyr	1796	23	in	in	IN
cord-006860-a3b8hyyr	1796	24	photometric	photometric	JJ
cord-006860-a3b8hyyr	1796	25	autoanalyzers	autoanalyzer	NNS
cord-006860-a3b8hyyr	1796	26	.	.	.
cord-006860-a3b8hyyr	1797	1	D	d	JJ
cord-006860-a3b8hyyr	1797	2	-	-	HYPH
cord-006860-a3b8hyyr	1797	3	direct	direct	JJ
cord-006860-a3b8hyyr	1797	4	antigen	antigen	NN
cord-006860-a3b8hyyr	1797	5	was	be	VBD
cord-006860-a3b8hyyr	1797	6	measured	measure	VBN
cord-006860-a3b8hyyr	1797	7	in	in	IN
cord-006860-a3b8hyyr	1797	8	parallel	parallel	NN
cord-006860-a3b8hyyr	1797	9	using	use	VBG
cord-006860-a3b8hyyr	1797	10	TINAqaant	tinaqaant	JJ
cord-006860-a3b8hyyr	1797	11	D	d	NN
cord-006860-a3b8hyyr	1797	12	-	-	HYPH
cord-006860-a3b8hyyr	1797	13	dimer	dimer	NN
cord-006860-a3b8hyyr	1797	14	LPIA	LPIA	NNP
cord-006860-a3b8hyyr	1797	15	.	.	.
cord-006860-a3b8hyyr	1798	1	Results	result	NNS
cord-006860-a3b8hyyr	1798	2	were	be	VBD
cord-006860-a3b8hyyr	1798	3	correlated	correlate	VBN
cord-006860-a3b8hyyr	1798	4	with	with	IN
cord-006860-a3b8hyyr	1798	5	total	total	JJ
cord-006860-a3b8hyyr	1798	6	fibrinopeptide	fibrinopeptide	NN
cord-006860-a3b8hyyr	1799	1	A	a	DT
cord-006860-a3b8hyyr	1799	2	release	release	NN
cord-006860-a3b8hyyr	1799	3	by	by	IN
cord-006860-a3b8hyyr	1799	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1799	5	,	,	,
cord-006860-a3b8hyyr	1799	6	measured	measure	VBN
cord-006860-a3b8hyyr	1799	7	by	by	IN
cord-006860-a3b8hyyr	1799	8	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	1799	9	.	.	.
cord-006860-a3b8hyyr	1800	1	A	a	DT
cord-006860-a3b8hyyr	1800	2	total	total	NN
cord-006860-a3b8hyyr	1800	3	of	of	IN
cord-006860-a3b8hyyr	1800	4	484	484	CD
cord-006860-a3b8hyyr	1800	5	samples	sample	NNS
cord-006860-a3b8hyyr	1800	6	were	be	VBD
cord-006860-a3b8hyyr	1800	7	included	include	VBN
cord-006860-a3b8hyyr	1800	8	,	,	,
cord-006860-a3b8hyyr	1800	9	of	of	IN
cord-006860-a3b8hyyr	1800	10	which	which	WDT
cord-006860-a3b8hyyr	1800	11	29	29	CD
cord-006860-a3b8hyyr	1800	12	samples	sample	NNS
cord-006860-a3b8hyyr	1800	13	(	(	-LRB-
cord-006860-a3b8hyyr	1800	14	6	6	CD
cord-006860-a3b8hyyr	1800	15	%	%	NN
cord-006860-a3b8hyyr	1800	16	)	)	-RRB-
cord-006860-a3b8hyyr	1800	17	were	be	VBD
cord-006860-a3b8hyyr	1800	18	recorded	record	VBN
cord-006860-a3b8hyyr	1800	19	as	as	IN
cord-006860-a3b8hyyr	1800	20	above	above	IN
cord-006860-a3b8hyyr	1800	21	measurung	measurung	JJ
cord-006860-a3b8hyyr	1800	22	range	range	NN
cord-006860-a3b8hyyr	1800	23	by	by	IN
cord-006860-a3b8hyyr	1800	24	derFbg	derFbg	NNP
cord-006860-a3b8hyyr	1800	25	.	.	.
cord-006860-a3b8hyyr	1801	1	These	these	DT
cord-006860-a3b8hyyr	1801	2	samples	sample	NNS
cord-006860-a3b8hyyr	1801	3	encompassed	encompass	VBD
cord-006860-a3b8hyyr	1801	4	a	a	DT
cord-006860-a3b8hyyr	1801	5	range	range	NN
cord-006860-a3b8hyyr	1801	6	of	of	IN
cord-006860-a3b8hyyr	1801	7	5.90	5.90	CD
cord-006860-a3b8hyyr	1801	8	-	-	SYM
cord-006860-a3b8hyyr	1801	9	10.40	10.40	CD
cord-006860-a3b8hyyr	1801	10	g	g	NN
cord-006860-a3b8hyyr	1801	11	/	/	SYM
cord-006860-a3b8hyyr	1801	12	l	l	NN
cord-006860-a3b8hyyr	1801	13	and	and	CC
cord-006860-a3b8hyyr	1801	14	5.21	5.21	CD
cord-006860-a3b8hyyr	1801	15	-	-	SYM
cord-006860-a3b8hyyr	1801	16	12.37	12.37	CD
cord-006860-a3b8hyyr	1801	17	g	g	NN
cord-006860-a3b8hyyr	1801	18	/	/	SYM
cord-006860-a3b8hyyr	1801	19	l	l	NN
cord-006860-a3b8hyyr	1801	20	in	in	IN
cord-006860-a3b8hyyr	1801	21	Clauss	Clauss	NNP
cord-006860-a3b8hyyr	1801	22	,	,	,
cord-006860-a3b8hyyr	1801	23	and	and	CC
cord-006860-a3b8hyyr	1801	24	turbidimetric	turbidimetric	JJ
cord-006860-a3b8hyyr	1801	25	assay	assay	NN
cord-006860-a3b8hyyr	1801	26	,	,	,
cord-006860-a3b8hyyr	1801	27	respectively	respectively	RB
cord-006860-a3b8hyyr	1801	28	.	.	.
cord-006860-a3b8hyyr	1802	1	The	the	DT
cord-006860-a3b8hyyr	1802	2	range	range	NN
cord-006860-a3b8hyyr	1802	3	of	of	IN
cord-006860-a3b8hyyr	1802	4	values	value	NNS
cord-006860-a3b8hyyr	1802	5	measured	measure	VBN
cord-006860-a3b8hyyr	1802	6	by	by	IN
cord-006860-a3b8hyyr	1802	7	derFbg	derFbg	NNP
cord-006860-a3b8hyyr	1802	8	assay	assay	NN
cord-006860-a3b8hyyr	1802	9	was	be	VBD
cord-006860-a3b8hyyr	1802	10	0.72	0.72	CD
cord-006860-a3b8hyyr	1802	11	-	-	SYM
cord-006860-a3b8hyyr	1802	12	9.14	9.14	CD
cord-006860-a3b8hyyr	1803	1	g	g	NNP
cord-006860-a3b8hyyr	1803	2	/	/	SYM
cord-006860-a3b8hyyr	1803	3	I	I	NNP
cord-006860-a3b8hyyr	1803	4	,	,	,
cord-006860-a3b8hyyr	1803	5	corresponding	correspond	VBG
cord-006860-a3b8hyyr	1803	6	to	to	IN
cord-006860-a3b8hyyr	1803	7	0.26	0.26	CD
cord-006860-a3b8hyyr	1803	8	-	-	SYM
cord-006860-a3b8hyyr	1803	9	11.00	11.00	CD
cord-006860-a3b8hyyr	1803	10	gll	gll	NN
cord-006860-a3b8hyyr	1803	11	and	and	CC
cord-006860-a3b8hyyr	1803	12	0.24	0.24	CD
cord-006860-a3b8hyyr	1803	13	-	-	SYM
cord-006860-a3b8hyyr	1803	14	10.48	10.48	CD
cord-006860-a3b8hyyr	1803	15	g/1	g/1	NNS
cord-006860-a3b8hyyr	1803	16	in	in	IN
cord-006860-a3b8hyyr	1803	17	the	the	DT
cord-006860-a3b8hyyr	1803	18	Clauss	Clauss	NNP
cord-006860-a3b8hyyr	1803	19	and	and	CC
cord-006860-a3b8hyyr	1803	20	turbidimetric	turbidimetric	JJ
cord-006860-a3b8hyyr	1803	21	assay	assay	NN
cord-006860-a3b8hyyr	1803	22	,	,	,
cord-006860-a3b8hyyr	1803	23	respectively	respectively	RB
cord-006860-a3b8hyyr	1803	24	.	.	.
cord-006860-a3b8hyyr	1804	1	The	the	DT
cord-006860-a3b8hyyr	1804	2	correlation	correlation	NN
cord-006860-a3b8hyyr	1804	3	of	of	IN
cord-006860-a3b8hyyr	1804	4	derFbg	derFbg	NNS
cord-006860-a3b8hyyr	1804	5	with	with	IN
cord-006860-a3b8hyyr	1804	6	the	the	DT
cord-006860-a3b8hyyr	1804	7	Clauss	Clauss	NNP
cord-006860-a3b8hyyr	1804	8	assay	assay	NN
cord-006860-a3b8hyyr	1804	9	was	be	VBD
cord-006860-a3b8hyyr	1804	10	re0.91	re0.91	RB
cord-006860-a3b8hyyr	1804	11	,	,	,
cord-006860-a3b8hyyr	1804	12	correlation	correlation	NN
cord-006860-a3b8hyyr	1804	13	with	with	IN
cord-006860-a3b8hyyr	1804	14	turbidimetric	turbidimetric	JJ
cord-006860-a3b8hyyr	1804	15	assay	assay	NN
cord-006860-a3b8hyyr	1804	16	was	be	VBD
cord-006860-a3b8hyyr	1804	17	r=0.92	r=0.92	NNP
cord-006860-a3b8hyyr	1804	18	for	for	IN
cord-006860-a3b8hyyr	1804	19	the	the	DT
cord-006860-a3b8hyyr	1804	20	values	value	NNS
cord-006860-a3b8hyyr	1804	21	actually	actually	RB
cord-006860-a3b8hyyr	1804	22	detected	detect	VBD
cord-006860-a3b8hyyr	1804	23	.	.	.
cord-006860-a3b8hyyr	1805	1	The	the	DT
cord-006860-a3b8hyyr	1805	2	correlation	correlation	NN
cord-006860-a3b8hyyr	1805	3	between	between	IN
cord-006860-a3b8hyyr	1805	4	Clauss	Clauss	NNP
cord-006860-a3b8hyyr	1805	5	and	and	CC
cord-006860-a3b8hyyr	1805	6	turbidimetric	turbidimetric	JJ
cord-006860-a3b8hyyr	1805	7	assay	assay	NN
cord-006860-a3b8hyyr	1805	8	was	be	VBD
cord-006860-a3b8hyyr	1805	9	r=0.93	r=0.93	JJ
cord-006860-a3b8hyyr	1805	10	for	for	IN
cord-006860-a3b8hyyr	1805	11	all	all	DT
cord-006860-a3b8hyyr	1805	12	values	value	NNS
cord-006860-a3b8hyyr	1805	13	.	.	.
cord-006860-a3b8hyyr	1806	1	There	there	EX
cord-006860-a3b8hyyr	1806	2	was	be	VBD
cord-006860-a3b8hyyr	1806	3	no	no	DT
cord-006860-a3b8hyyr	1806	4	dependency	dependency	NN
cord-006860-a3b8hyyr	1806	5	of	of	IN
cord-006860-a3b8hyyr	1806	6	test	test	NN
cord-006860-a3b8hyyr	1806	7	results	result	NNS
cord-006860-a3b8hyyr	1806	8	or	or	CC
cord-006860-a3b8hyyr	1806	9	inter	inter	JJ
cord-006860-a3b8hyyr	1806	10	-	-	JJ
cord-006860-a3b8hyyr	1806	11	test	test	JJ
cord-006860-a3b8hyyr	1806	12	variation	variation	NN
cord-006860-a3b8hyyr	1806	13	upon	upon	IN
cord-006860-a3b8hyyr	1806	14	D	d	NN
cord-006860-a3b8hyyr	1806	15	-	-	NN
cord-006860-a3b8hyyr	1806	16	direct	direct	JJ
cord-006860-a3b8hyyr	1806	17	.	.	.
cord-006860-a3b8hyyr	1807	1	Correlation	correlation	NN
cord-006860-a3b8hyyr	1807	2	graphs	graph	NNS
cord-006860-a3b8hyyr	1807	3	displayed	display	VBD
cord-006860-a3b8hyyr	1807	4	a	a	DT
cord-006860-a3b8hyyr	1807	5	decreased	decreased	JJ
cord-006860-a3b8hyyr	1807	6	test	test	NN
cord-006860-a3b8hyyr	1807	7	response	response	NN
cord-006860-a3b8hyyr	1807	8	of	of	IN
cord-006860-a3b8hyyr	1807	9	Clauss	Clauss	NNP
cord-006860-a3b8hyyr	1807	10	assay	assay	NN
cord-006860-a3b8hyyr	1807	11	in	in	IN
cord-006860-a3b8hyyr	1807	12	the	the	DT
cord-006860-a3b8hyyr	1807	13	high	high	JJ
cord-006860-a3b8hyyr	1807	14	concentration	concentration	NN
cord-006860-a3b8hyyr	1807	15	range	range	NN
cord-006860-a3b8hyyr	1807	16	,	,	,
cord-006860-a3b8hyyr	1807	17	resulting	result	VBG
cord-006860-a3b8hyyr	1807	18	in	in	IN
cord-006860-a3b8hyyr	1807	19	an	an	DT
cord-006860-a3b8hyyr	1807	20	underestimation	underestimation	NN
cord-006860-a3b8hyyr	1807	21	of	of	IN
cord-006860-a3b8hyyr	1807	22	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1807	23	concentration	concentration	NN
cord-006860-a3b8hyyr	1807	24	.	.	.
cord-006860-a3b8hyyr	1808	1	The	the	DT
cord-006860-a3b8hyyr	1808	2	derFbg	derfbg	JJ
cord-006860-a3b8hyyr	1808	3	assay	assay	NN
cord-006860-a3b8hyyr	1808	4	,	,	,
cord-006860-a3b8hyyr	1808	5	in	in	IN
cord-006860-a3b8hyyr	1808	6	contrast	contrast	NN
cord-006860-a3b8hyyr	1808	7	,	,	,
cord-006860-a3b8hyyr	1808	8	showed	show	VBD
cord-006860-a3b8hyyr	1808	9	normal	normal	JJ
cord-006860-a3b8hyyr	1808	10	range	range	NN
cord-006860-a3b8hyyr	1808	11	values	value	NNS
cord-006860-a3b8hyyr	1808	12	in	in	IN
cord-006860-a3b8hyyr	1808	13	samples	sample	NNS
cord-006860-a3b8hyyr	1808	14	from	from	IN
cord-006860-a3b8hyyr	1808	15	patients	patient	NNS
cord-006860-a3b8hyyr	1808	16	with	with	IN
cord-006860-a3b8hyyr	1808	17	fibrinotytic	fibrinotytic	JJ
cord-006860-a3b8hyyr	1808	18	treatment	treatment	NN
cord-006860-a3b8hyyr	1808	19	and	and	CC
cord-006860-a3b8hyyr	1808	20	low	low	JJ
cord-006860-a3b8hyyr	1808	21	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1808	22	levels	level	NNS
cord-006860-a3b8hyyr	1808	23	in	in	IN
cord-006860-a3b8hyyr	1808	24	the	the	DT
cord-006860-a3b8hyyr	1808	25	other	other	JJ
cord-006860-a3b8hyyr	1808	26	assays	assay	NNS
cord-006860-a3b8hyyr	1808	27	.	.	.
cord-006860-a3b8hyyr	1809	1	Correlation	correlation	NN
cord-006860-a3b8hyyr	1809	2	with	with	IN
cord-006860-a3b8hyyr	1809	3	fibrinopeptide	fibrinopeptide	NN
cord-006860-a3b8hyyr	1810	1	A	a	DT
cord-006860-a3b8hyyr	1810	2	release	release	NN
cord-006860-a3b8hyyr	1810	3	was	be	VBD
cord-006860-a3b8hyyr	1810	4	r=0.88	r=0.88	NNP
cord-006860-a3b8hyyr	1810	5	for	for	IN
cord-006860-a3b8hyyr	1810	6	Clauss	Clauss	NNP
cord-006860-a3b8hyyr	1810	7	assay	assay	NN
cord-006860-a3b8hyyr	1810	8	,	,	,
cord-006860-a3b8hyyr	1810	9	r=0.89	r=0.89	NNP
cord-006860-a3b8hyyr	1810	10	for	for	IN
cord-006860-a3b8hyyr	1810	11	turbidimetric	turbidimetric	JJ
cord-006860-a3b8hyyr	1810	12	assay	assay	NN
cord-006860-a3b8hyyr	1810	13	,	,	,
cord-006860-a3b8hyyr	1810	14	and	and	CC
cord-006860-a3b8hyyr	1810	15	r=0.82	r=0.82	NNP
cord-006860-a3b8hyyr	1810	16	for	for	IN
cord-006860-a3b8hyyr	1810	17	derFbg	derFbg	NNS
cord-006860-a3b8hyyr	1810	18	.	.	.
cord-006860-a3b8hyyr	1811	1	For	for	IN
cord-006860-a3b8hyyr	1811	2	clinical	clinical	JJ
cord-006860-a3b8hyyr	1811	3	routine	routine	NN
cord-006860-a3b8hyyr	1811	4	,	,	,
cord-006860-a3b8hyyr	1811	5	derFbg	derFbg	NNP
cord-006860-a3b8hyyr	1811	6	appears	appear	VBZ
cord-006860-a3b8hyyr	1811	7	to	to	TO
cord-006860-a3b8hyyr	1811	8	be	be	VB
cord-006860-a3b8hyyr	1811	9	applicable	applicable	JJ
cord-006860-a3b8hyyr	1811	10	for	for	IN
cord-006860-a3b8hyyr	1811	11	all	all	DT
cord-006860-a3b8hyyr	1811	12	samples	sample	NNS
cord-006860-a3b8hyyr	1811	13	between	between	IN
cord-006860-a3b8hyyr	1811	14	1.00	1.00	CD
cord-006860-a3b8hyyr	1811	15	and	and	CC
cord-006860-a3b8hyyr	1811	16	5.00	5.00	CD
cord-006860-a3b8hyyr	1811	17	g	g	NN
cord-006860-a3b8hyyr	1811	18	/	/	SYM
cord-006860-a3b8hyyr	1811	19	l	l	NN
cord-006860-a3b8hyyr	1811	20	with	with	IN
cord-006860-a3b8hyyr	1811	21	exclusion	exclusion	NN
cord-006860-a3b8hyyr	1811	22	of	of	IN
cord-006860-a3b8hyyr	1811	23	samples	sample	NNS
cord-006860-a3b8hyyr	1811	24	from	from	IN
cord-006860-a3b8hyyr	1811	25	patients	patient	NNS
cord-006860-a3b8hyyr	1811	26	with	with	IN
cord-006860-a3b8hyyr	1811	27	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1811	28	treatment	treatment	NN
cord-006860-a3b8hyyr	1811	29	or	or	CC
cord-006860-a3b8hyyr	1811	30	endogeneous	endogeneous	NNP
cord-006860-a3b8hyyr	1811	31	hyperfibrinolysis	hyperfibrinolysis	NNP
cord-006860-a3b8hyyr	1811	32	.	.	.
cord-006860-a3b8hyyr	1812	1	Other	other	JJ
cord-006860-a3b8hyyr	1812	2	samples	sample	NNS
cord-006860-a3b8hyyr	1812	3	may	may	MD
cord-006860-a3b8hyyr	1812	4	be	be	VB
cord-006860-a3b8hyyr	1812	5	analyzed	analyze	VBN
cord-006860-a3b8hyyr	1812	6	by	by	IN
cord-006860-a3b8hyyr	1812	7	clotting	clot	VBG
cord-006860-a3b8hyyr	1812	8	assay	assay	NN
cord-006860-a3b8hyyr	1812	9	or	or	CC
cord-006860-a3b8hyyr	1812	10	turbidimetric	turbidimetric	JJ
cord-006860-a3b8hyyr	1812	11	assay	assay	NN
cord-006860-a3b8hyyr	1812	12	,	,	,
cord-006860-a3b8hyyr	1812	13	although	although	IN
cord-006860-a3b8hyyr	1812	14	the	the	DT
cord-006860-a3b8hyyr	1812	15	latter	latter	NN
cord-006860-a3b8hyyr	1812	16	appears	appear	VBZ
cord-006860-a3b8hyyr	1812	17	to	to	TO
cord-006860-a3b8hyyr	1812	18	be	be	VB
cord-006860-a3b8hyyr	1812	19	more	more	RBR
cord-006860-a3b8hyyr	1812	20	suited	suited	JJ
cord-006860-a3b8hyyr	1812	21	for	for	IN
cord-006860-a3b8hyyr	1812	22	measurement	measurement	NN
cord-006860-a3b8hyyr	1812	23	Of	of	IN
cord-006860-a3b8hyyr	1812	24	high	high	JJ
cord-006860-a3b8hyyr	1812	25	range	range	NN
cord-006860-a3b8hyyr	1812	26	samples	sample	NNS
cord-006860-a3b8hyyr	1812	27	.	.	.
cord-006860-a3b8hyyr	1813	1	for	for	IN
cord-006860-a3b8hyyr	1813	2	inhibition	inhibition	NN
cord-006860-a3b8hyyr	1813	3	of	of	IN
cord-006860-a3b8hyyr	1813	4	PK	PK	NNP
cord-006860-a3b8hyyr	1813	5	is	be	VBZ
cord-006860-a3b8hyyr	1813	6	0.067	0.067	CD
cord-006860-a3b8hyyr	1813	7	pmol	pmol	NN
cord-006860-a3b8hyyr	1813	8	/	/	SYM
cord-006860-a3b8hyyr	1813	9	L	l	NN
cord-006860-a3b8hyyr	1814	1	The	the	DT
cord-006860-a3b8hyyr	1814	2	antifibrinolytic	antifibrinolytic	JJ
cord-006860-a3b8hyyr	1814	3	activity	activity	NN
cord-006860-a3b8hyyr	1814	4	of	of	IN
cord-006860-a3b8hyyr	1814	5	the	the	DT
cord-006860-a3b8hyyr	1814	6	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1814	7	was	be	VBD
cord-006860-a3b8hyyr	1814	8	determined	determine	VBN
cord-006860-a3b8hyyr	1814	9	by	by	IN
cord-006860-a3b8hyyr	1814	10	measuring	measure	VBG
cord-006860-a3b8hyyr	1814	11	the	the	DT
cord-006860-a3b8hyyr	1814	12	lysis	lysis	NN
cord-006860-a3b8hyyr	1814	13	of	of	IN
cord-006860-a3b8hyyr	1814	14	radiolabelled	radiolabelled	JJ
cord-006860-a3b8hyyr	1814	15	human	human	JJ
cord-006860-a3b8hyyr	1814	16	plasma	plasma	NN
cord-006860-a3b8hyyr	1814	17	clots•	clots•	NNP
cord-006860-a3b8hyyr	1815	1	The	the	DT
cord-006860-a3b8hyyr	1815	2	compounds	compound	NNS
cord-006860-a3b8hyyr	1815	3	which	which	WDT
cord-006860-a3b8hyyr	1815	4	inhibit	inhibit	VBP
cord-006860-a3b8hyyr	1815	5	plasmin	plasmin	NN
cord-006860-a3b8hyyr	1815	6	and	and	CC
cord-006860-a3b8hyyr	1815	7	PK	PK	NNP
cord-006860-a3b8hyyr	1815	8	influence	influence	NN
cord-006860-a3b8hyyr	1815	9	remarkably	remarkably	RB
cord-006860-a3b8hyyr	1815	10	the	the	DT
cord-006860-a3b8hyyr	1815	11	streptokinase	streptokinase	NNP
cord-006860-a3b8hyyr	1815	12	-	-	HYPH
cord-006860-a3b8hyyr	1815	13	induced	induce	VBN
cord-006860-a3b8hyyr	1815	14	clot	clot	NN
cord-006860-a3b8hyyr	1815	15	lysis	lysis	NN
cord-006860-a3b8hyyr	1815	16	but	but	CC
cord-006860-a3b8hyyr	1815	17	not	not	RB
cord-006860-a3b8hyyr	1815	18	lysis	lysis	NN
cord-006860-a3b8hyyr	1815	19	induced	induce	VBN
cord-006860-a3b8hyyr	1815	20	by	by	IN
cord-006860-a3b8hyyr	1815	21	UK	UK	NNP
cord-006860-a3b8hyyr	1815	22	and	and	CC
cord-006860-a3b8hyyr	1815	23	tPA	tPA	NNP
cord-006860-a3b8hyyr	1815	24	.	.	.
cord-006860-a3b8hyyr	1816	1	Surprisingly	surprisingly	RB
cord-006860-a3b8hyyr	1816	2	,	,	,
cord-006860-a3b8hyyr	1816	3	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1816	4	of	of	IN
cord-006860-a3b8hyyr	1816	5	UK	UK	NNP
cord-006860-a3b8hyyr	1816	6	and	and	CC
cord-006860-a3b8hyyr	1816	7	tPA	tPA	NNP
cord-006860-a3b8hyyr	1816	8	do	do	VBP
cord-006860-a3b8hyyr	1816	9	not	not	RB
cord-006860-a3b8hyyr	1816	10	influence	influence	VB
cord-006860-a3b8hyyr	1816	11	clot	clot	NN
cord-006860-a3b8hyyr	1816	12	lysis	lysis	NN
cord-006860-a3b8hyyr	1816	13	induced	induce	VBN
cord-006860-a3b8hyyr	1816	14	by	by	IN
cord-006860-a3b8hyyr	1816	15	UK	UK	NNP
cord-006860-a3b8hyyr	1816	16	or	or	CC
cord-006860-a3b8hyyr	1816	17	tPA	tPA	NNP
cord-006860-a3b8hyyr	1816	18	.	.	.
cord-006860-a3b8hyyr	1817	1	The	the	DT
cord-006860-a3b8hyyr	1817	2	structure	structure	NN
cord-006860-a3b8hyyr	1817	3	-	-	HYPH
cord-006860-a3b8hyyr	1817	4	activity	activity	NN
cord-006860-a3b8hyyr	1817	5	relationships	relationship	NNS
cord-006860-a3b8hyyr	1817	6	for	for	IN
cord-006860-a3b8hyyr	1817	7	inhibition	inhibition	NN
cord-006860-a3b8hyyr	1817	8	of	of	IN
cord-006860-a3b8hyyr	1817	9	ptasmin	ptasmin	NNP
cord-006860-a3b8hyyr	1817	10	,	,	,
cord-006860-a3b8hyyr	1817	11	UK	UK	NNP
cord-006860-a3b8hyyr	1817	12	,	,	,
cord-006860-a3b8hyyr	1817	13	tPA	tPA	NNP
cord-006860-a3b8hyyr	1817	14	and	and	CC
cord-006860-a3b8hyyr	1817	15	PK	PK	NNP
cord-006860-a3b8hyyr	1817	16	could	could	MD
cord-006860-a3b8hyyr	1817	17	help	help	VB
cord-006860-a3b8hyyr	1817	18	in	in	IN
cord-006860-a3b8hyyr	1817	19	the	the	DT
cord-006860-a3b8hyyr	1817	20	design	design	NN
cord-006860-a3b8hyyr	1817	21	of	of	IN
cord-006860-a3b8hyyr	1817	22	more	more	RBR
cord-006860-a3b8hyyr	1817	23	potent	potent	JJ
cord-006860-a3b8hyyr	1817	24	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1817	25	of	of	IN
cord-006860-a3b8hyyr	1817	26	fibrinotytic	fibrinotytic	JJ
cord-006860-a3b8hyyr	1817	27	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	1817	28	.	.	.
cord-006860-a3b8hyyr	1818	1	UK	UK	NNP
cord-006860-a3b8hyyr	1818	2	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1818	3	are	be	VBP
cord-006860-a3b8hyyr	1818	4	of	of	IN
cord-006860-a3b8hyyr	1818	5	interest	interest	NN
cord-006860-a3b8hyyr	1818	6	for	for	IN
cord-006860-a3b8hyyr	1818	7	the	the	DT
cord-006860-a3b8hyyr	1818	8	development	development	NN
cord-006860-a3b8hyyr	1818	9	of	of	IN
cord-006860-a3b8hyyr	1818	10	anti	anti	JJ
cord-006860-a3b8hyyr	1818	11	-	-	JJ
cord-006860-a3b8hyyr	1818	12	invasiveness	invasiveness	JJ
cord-006860-a3b8hyyr	1818	13	drugs	drug	NNS
cord-006860-a3b8hyyr	1818	14	,	,	,
cord-006860-a3b8hyyr	1818	15	while	while	IN
cord-006860-a3b8hyyr	1818	16	plasmin	plasmin	NNP
cord-006860-a3b8hyyr	1818	17	/	/	SYM
cord-006860-a3b8hyyr	1818	18	PK	PK	NNP
cord-006860-a3b8hyyr	1818	19	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1818	20	could	could	MD
cord-006860-a3b8hyyr	1818	21	be	be	VB
cord-006860-a3b8hyyr	1818	22	prototypes	prototype	NNS
cord-006860-a3b8hyyr	1818	23	of	of	IN
cord-006860-a3b8hyyr	1818	24	a	a	DT
cord-006860-a3b8hyyr	1818	25	"	"	``
cord-006860-a3b8hyyr	1818	26	synthetic	synthetic	JJ
cord-006860-a3b8hyyr	1818	27	aprotinin	aprotinin	NNS
cord-006860-a3b8hyyr	1818	28	"	"	''
cord-006860-a3b8hyyr	1818	29	.	.	.
cord-006860-a3b8hyyr	1819	1	In	in	IN
cord-006860-a3b8hyyr	1819	2	the	the	DT
cord-006860-a3b8hyyr	1819	3	ECAT	ECAT	NNP
cord-006860-a3b8hyyr	1819	4	Angina	Angina	NNP
cord-006860-a3b8hyyr	1819	5	Pectoris	Pectoris	NNP
cord-006860-a3b8hyyr	1819	6	Study	Study	NNP
cord-006860-a3b8hyyr	1819	7	t	t	NNP
cord-006860-a3b8hyyr	1819	8	-	-	HYPH
cord-006860-a3b8hyyr	1819	9	PA	PA	NNP
cord-006860-a3b8hyyr	1819	10	antigen	antigen	NN
cord-006860-a3b8hyyr	1819	11	was	be	VBD
cord-006860-a3b8hyyr	1819	12	an	an	DT
cord-006860-a3b8hyyr	1819	13	indepcndem	indepcndem	JJ
cord-006860-a3b8hyyr	1819	14	risk	risk	NN
cord-006860-a3b8hyyr	1819	15	factor	factor	NN
cord-006860-a3b8hyyr	1819	16	of	of	IN
cord-006860-a3b8hyyr	1819	17	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	1819	18	acute	acute	JJ
cord-006860-a3b8hyyr	1819	19	coronary	coronary	JJ
cord-006860-a3b8hyyr	1819	20	syndromes	syndrome	NNS
cord-006860-a3b8hyyr	1819	21	.	.	.
cord-006860-a3b8hyyr	1820	1	PAt	PAt	NNP
cord-006860-a3b8hyyr	1820	2	indicates	indicate	VBZ
cord-006860-a3b8hyyr	1820	3	the	the	DT
cord-006860-a3b8hyyr	1820	4	risk	risk	NN
cord-006860-a3b8hyyr	1820	5	bat	bat	NN
cord-006860-a3b8hyyr	1820	6	depends	depend	VBZ
cord-006860-a3b8hyyr	1820	7	on	on	IN
cord-006860-a3b8hyyr	1820	8	other	other	JJ
cord-006860-a3b8hyyr	1820	9	known	know	VBN
cord-006860-a3b8hyyr	1820	10	risk	risk	NN
cord-006860-a3b8hyyr	1820	11	factors	factor	NNS
cord-006860-a3b8hyyr	1820	12	.	.	.
cord-006860-a3b8hyyr	1821	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1821	2	should	should	MD
cord-006860-a3b8hyyr	1821	3	be	be	VB
cord-006860-a3b8hyyr	1821	4	tested	test	VBN
cord-006860-a3b8hyyr	1821	5	in	in	IN
cord-006860-a3b8hyyr	1821	6	183	183	CD
cord-006860-a3b8hyyr	1821	7	members	member	NNS
cord-006860-a3b8hyyr	1821	8	of	of	IN
cord-006860-a3b8hyyr	1821	9	a	a	DT
cord-006860-a3b8hyyr	1821	10	family	family	NN
cord-006860-a3b8hyyr	1821	11	cohort	cohort	NN
cord-006860-a3b8hyyr	1821	12	study	study	NN
cord-006860-a3b8hyyr	1821	13	(	(	-LRB-
cord-006860-a3b8hyyr	1821	14	patients	patient	NNS
cord-006860-a3b8hyyr	1821	15	with	with	IN
cord-006860-a3b8hyyr	1821	16	combined	combine	VBN
cord-006860-a3b8hyyr	1821	17	hyperlipidaemia	hyperlipidaemia	NN
cord-006860-a3b8hyyr	1821	18	and	and	CC
cord-006860-a3b8hyyr	1821	19	/	/	SYM
cord-006860-a3b8hyyr	1821	20	or	or	CC
cord-006860-a3b8hyyr	1821	21	hyperuricaemia	hyperuricaemia	NNP
cord-006860-a3b8hyyr	1821	22	)	)	-RRB-
cord-006860-a3b8hyyr	1821	23	,	,	,
cord-006860-a3b8hyyr	1821	24	if	if	IN
cord-006860-a3b8hyyr	1821	25	the	the	DT
cord-006860-a3b8hyyr	1821	26	active	active	JJ
cord-006860-a3b8hyyr	1821	27	PAl	PAl	NNS
cord-006860-a3b8hyyr	1821	28	antigen	antigen	NN
cord-006860-a3b8hyyr	1821	29	or	or	CC
cord-006860-a3b8hyyr	1821	30	the	the	DT
cord-006860-a3b8hyyr	1821	31	whole	whole	JJ
cord-006860-a3b8hyyr	1821	32	PAI	PAI	NNP
cord-006860-a3b8hyyr	1821	33	antigen	antigen	NN
cord-006860-a3b8hyyr	1821	34	showed	show	VBD
cord-006860-a3b8hyyr	1821	35	a	a	DT
cord-006860-a3b8hyyr	1821	36	stronger	strong	JJR
cord-006860-a3b8hyyr	1821	37	relation	relation	NN
cord-006860-a3b8hyyr	1821	38	to	to	IN
cord-006860-a3b8hyyr	1821	39	t	t	NNP
cord-006860-a3b8hyyr	1821	40	-	-	HYPH
cord-006860-a3b8hyyr	1821	41	PA	PA	NNP
cord-006860-a3b8hyyr	1821	42	and	and	CC
cord-006860-a3b8hyyr	1821	43	metabolic	metabolic	JJ
cord-006860-a3b8hyyr	1821	44	variables	variable	NNS
cord-006860-a3b8hyyr	1821	45	.	.	.
cord-006860-a3b8hyyr	1822	1	The	the	DT
cord-006860-a3b8hyyr	1822	2	active	active	JJ
cord-006860-a3b8hyyr	1822	3	PAll	PAll	NNP
cord-006860-a3b8hyyr	1822	4	antigen	antigen	NN
cord-006860-a3b8hyyr	1822	5	was	be	VBD
cord-006860-a3b8hyyr	1822	6	determined	determine	VBN
cord-006860-a3b8hyyr	1822	7	using	use	VBG
cord-006860-a3b8hyyr	1822	8	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	1822	9	Actibind	Actibind	NNP
cord-006860-a3b8hyyr	1822	10	PAt-1	PAt-1	NNP
cord-006860-a3b8hyyr	1822	11	(	(	-LRB-
cord-006860-a3b8hyyr	1822	12	Technoclone	Technoclone	NNP
cord-006860-a3b8hyyr	1822	13	/	/	SYM
cord-006860-a3b8hyyr	1822	14	lmmuno	lmmuno	NNP
cord-006860-a3b8hyyr	1822	15	)	)	-RRB-
cord-006860-a3b8hyyr	1822	16	,	,	.
cord-006860-a3b8hyyr	1823	1	the	the	DT
cord-006860-a3b8hyyr	1823	2	whole	whole	JJ
cord-006860-a3b8hyyr	1823	3	PAI	PAI	NNP
cord-006860-a3b8hyyr	1823	4	-	-	HYPH
cord-006860-a3b8hyyr	1823	5	I	I	NNP
cord-006860-a3b8hyyr	1823	6	antigen	antigen	NN
cord-006860-a3b8hyyr	1823	7	was	be	VBD
cord-006860-a3b8hyyr	1823	8	measured	measure	VBN
cord-006860-a3b8hyyr	1823	9	using	use	VBG
cord-006860-a3b8hyyr	1823	10	the	the	DT
cord-006860-a3b8hyyr	1823	11	F_LISA	f_lisa	CD
cord-006860-a3b8hyyr	1823	12	PAt-1	pat-1	NN
cord-006860-a3b8hyyr	1824	1	(	(	-LRB-
cord-006860-a3b8hyyr	1824	2	Technoclone	Technoclone	NNP
cord-006860-a3b8hyyr	1824	3	I	-PRON-	PRP
cord-006860-a3b8hyyr	1824	4	Immuno	Immuno	NNP
cord-006860-a3b8hyyr	1824	5	)	)	-RRB-
cord-006860-a3b8hyyr	1824	6	.	.	.
cord-006860-a3b8hyyr	1825	1	t	t	NNP
cord-006860-a3b8hyyr	1825	2	-	-	HYPH
cord-006860-a3b8hyyr	1825	3	PA	PA	NNP
cord-006860-a3b8hyyr	1825	4	activity	activity	NN
cord-006860-a3b8hyyr	1825	5	was	be	VBD
cord-006860-a3b8hyyr	1825	6	determined	determine	VBN
cord-006860-a3b8hyyr	1825	7	with	with	IN
cord-006860-a3b8hyyr	1825	8	the	the	DT
cord-006860-a3b8hyyr	1825	9	Coaset	Coaset	NNP
cord-006860-a3b8hyyr	1825	10	t	t	NNP
cord-006860-a3b8hyyr	1825	11	-	-	HYPH
cord-006860-a3b8hyyr	1825	12	PA	PA	NNP
cord-006860-a3b8hyyr	1825	13	from	from	IN
cord-006860-a3b8hyyr	1825	14	Chromogenix	Chromogenix	NNP
cord-006860-a3b8hyyr	1825	15	,	,	,
cord-006860-a3b8hyyr	1825	16	the	the	DT
cord-006860-a3b8hyyr	1825	17	TintElize	TintElize	NNP
cord-006860-a3b8hyyr	1825	18	tPA	tPA	NNP
cord-006860-a3b8hyyr	1825	19	from	from	IN
cord-006860-a3b8hyyr	1825	20	Biopool	Biopool	NNP
cord-006860-a3b8hyyr	1825	21	was	be	VBD
cord-006860-a3b8hyyr	1825	22	the	the	DT
cord-006860-a3b8hyyr	1825	23	used	used	JJ
cord-006860-a3b8hyyr	1825	24	test	test	NN
cord-006860-a3b8hyyr	1825	25	for	for	IN
cord-006860-a3b8hyyr	1825	26	determination	determination	NN
cord-006860-a3b8hyyr	1825	27	of	of	IN
cord-006860-a3b8hyyr	1825	28	t	t	NNP
cord-006860-a3b8hyyr	1825	29	-	-	HYPH
cord-006860-a3b8hyyr	1825	30	PA	PA	NNP
cord-006860-a3b8hyyr	1825	31	antigen	antigen	NN
cord-006860-a3b8hyyr	1825	32	.	.	.
cord-006860-a3b8hyyr	1826	1	The	the	DT
cord-006860-a3b8hyyr	1826	2	active	active	JJ
cord-006860-a3b8hyyr	1826	3	PAt	pat	NN
cord-006860-a3b8hyyr	1826	4	antigen	antigen	NN
cord-006860-a3b8hyyr	1826	5	showed	show	VBD
cord-006860-a3b8hyyr	1826	6	a	a	DT
cord-006860-a3b8hyyr	1826	7	stronger	strong	JJR
cord-006860-a3b8hyyr	1826	8	correlation	correlation	NN
cord-006860-a3b8hyyr	1826	9	to	to	IN
cord-006860-a3b8hyyr	1826	10	t	t	NNP
cord-006860-a3b8hyyr	1826	11	-	-	HYPH
cord-006860-a3b8hyyr	1826	12	PA	PA	NNP
cord-006860-a3b8hyyr	1826	13	activity	activity	NN
cord-006860-a3b8hyyr	1826	14	and	and	CC
cord-006860-a3b8hyyr	1826	15	t	t	NNP
cord-006860-a3b8hyyr	1826	16	-	-	HYPH
cord-006860-a3b8hyyr	1826	17	PA	PA	NNP
cord-006860-a3b8hyyr	1826	18	antigen	antigen	NN
cord-006860-a3b8hyyr	1826	19	than	than	IN
cord-006860-a3b8hyyr	1826	20	the	the	DT
cord-006860-a3b8hyyr	1826	21	whole	whole	JJ
cord-006860-a3b8hyyr	1826	22	PAl	PAl	NNS
cord-006860-a3b8hyyr	1826	23	antigen	antigen	NN
cord-006860-a3b8hyyr	1826	24	.	.	.
cord-006860-a3b8hyyr	1827	1	Circulating	circulate	VBG
cord-006860-a3b8hyyr	1827	2	t	t	NNP
cord-006860-a3b8hyyr	1827	3	-	-	HYPH
cord-006860-a3b8hyyr	1827	4	PA	PA	NNP
cord-006860-a3b8hyyr	1827	5	activity	activity	NN
cord-006860-a3b8hyyr	1827	6	was	be	VBD
cord-006860-a3b8hyyr	1827	7	influenced	influence	VBN
cord-006860-a3b8hyyr	1827	8	predominantly	predominantly	RB
cord-006860-a3b8hyyr	1827	9	by	by	IN
cord-006860-a3b8hyyr	1827	10	the	the	DT
cord-006860-a3b8hyyr	1827	11	active	active	JJ
cord-006860-a3b8hyyr	1827	12	PAl	PAl	NNS
cord-006860-a3b8hyyr	1827	13	antigen	antigen	NN
cord-006860-a3b8hyyr	1827	14	.	.	.
cord-006860-a3b8hyyr	1828	1	Both	both	DT
cord-006860-a3b8hyyr	1828	2	PAt	pat	NN
cord-006860-a3b8hyyr	1828	3	antigens	antigen	NNS
cord-006860-a3b8hyyr	1828	4	were	be	VBD
cord-006860-a3b8hyyr	1828	5	correlated	correlate	VBN
cord-006860-a3b8hyyr	1828	6	in	in	IN
cord-006860-a3b8hyyr	1828	7	similar	similar	JJ
cord-006860-a3b8hyyr	1828	8	manner	manner	NN
cord-006860-a3b8hyyr	1828	9	with	with	IN
cord-006860-a3b8hyyr	1828	10	metabolic	metabolic	JJ
cord-006860-a3b8hyyr	1828	11	variables	variable	NNS
cord-006860-a3b8hyyr	1828	12	,	,	,
cord-006860-a3b8hyyr	1828	13	lipoproteins	lipoprotein	NNS
cord-006860-a3b8hyyr	1828	14	and	and	CC
cord-006860-a3b8hyyr	1828	15	B	b	NN
cord-006860-a3b8hyyr	1828	16	/	/	SYM
cord-006860-a3b8hyyr	1828	17	VII	vii	NN
cord-006860-a3b8hyyr	1828	18	.	.	.
cord-006860-a3b8hyyr	1829	1	Table	table	NN
cord-006860-a3b8hyyr	1829	2	:	:	:
cord-006860-a3b8hyyr	1830	1	Correlations	correlation	NNS
cord-006860-a3b8hyyr	1830	2	of	of	IN
cord-006860-a3b8hyyr	1830	3	active	active	JJ
cord-006860-a3b8hyyr	1830	4	and	and	CC
cord-006860-a3b8hyyr	1830	5	whole	whole	JJ
cord-006860-a3b8hyyr	1830	6	PAl	pal	NN
cord-006860-a3b8hyyr	1830	7	antigen	antigen	NN
cord-006860-a3b8hyyr	1830	8	(	(	-LRB-
cord-006860-a3b8hyyr	1831	1	*	*	NFP
cord-006860-a3b8hyyr	1831	2	*	*	NFP
cord-006860-a3b8hyyr	1831	3	p	p	XX
cord-006860-a3b8hyyr	1831	4	<	<	XX
cord-006860-a3b8hyyr	1831	5	0,001	0,001	CD
cord-006860-a3b8hyyr	1831	6	)	)	-RRB-
cord-006860-a3b8hyyr	1832	1	active	active	JJ
cord-006860-a3b8hyyr	1832	2	PAl	PAl	NNS
cord-006860-a3b8hyyr	1832	3	antigen	antigen	NN
cord-006860-a3b8hyyr	1832	4	whole	whole	JJ
cord-006860-a3b8hyyr	1832	5	PAl	PAl	NNS
cord-006860-a3b8hyyr	1832	6	antigen	antigen	NN
cord-006860-a3b8hyyr	1832	7	active	active	JJ
cord-006860-a3b8hyyr	1832	8	PAt	PAt	NNS
cord-006860-a3b8hyyr	1832	9	antigen	antigen	NN
cord-006860-a3b8hyyr	1832	10	1,000	1,000	CD
cord-006860-a3b8hyyr	1832	11	0,851	0,851	CD
cord-006860-a3b8hyyr	1833	1	*	*	NFP
cord-006860-a3b8hyyr	1833	2	*	*	NFP
cord-006860-a3b8hyyr	1833	3	whole	whole	JJ
cord-006860-a3b8hyyr	1833	4	PAl	pal	NN
cord-006860-a3b8hyyr	1833	5	antigen	antigen	NNP
cord-006860-a3b8hyyr	1833	6	0,851	0,851	CD
cord-006860-a3b8hyyr	1834	1	*	*	NFP
cord-006860-a3b8hyyr	1834	2	*	*	NFP
cord-006860-a3b8hyyr	1834	3	1,000	1,000	CD
cord-006860-a3b8hyyr	1834	4	t	t	NNP
cord-006860-a3b8hyyr	1834	5	-	-	HYPH
cord-006860-a3b8hyyr	1834	6	PA	PA	NNP
cord-006860-a3b8hyyr	1834	7	activity	activity	NN
cord-006860-a3b8hyyr	1834	8	-0,594	-0,594	XX
cord-006860-a3b8hyyr	1835	1	*	*	NFP
cord-006860-a3b8hyyr	1835	2	*	*	NFP
cord-006860-a3b8hyyr	1835	3	-0,492	-0,492	NFP
cord-006860-a3b8hyyr	1835	4	*	*	NFP
cord-006860-a3b8hyyr	1835	5	*	*	NFP
cord-006860-a3b8hyyr	1835	6	bPA	bpa	NN
cord-006860-a3b8hyyr	1835	7	antigen	antigen	NNP
cord-006860-a3b8hyyr	1835	8	0,604	0,604	CD
cord-006860-a3b8hyyr	1836	1	*	*	NFP
cord-006860-a3b8hyyr	1836	2	*	*	NFP
cord-006860-a3b8hyyr	1836	3	0,497	0,497	CD
cord-006860-a3b8hyyr	1837	1	*	*	NFP
cord-006860-a3b8hyyr	1837	2	*	*	NFP
cord-006860-a3b8hyyr	1837	3	body	body	NNP
cord-006860-a3b8hyyr	1837	4	mass	mass	NNP
cord-006860-a3b8hyyr	1837	5	index	index	NN
cord-006860-a3b8hyyr	1837	6	0,502	0,502	CD
cord-006860-a3b8hyyr	1838	1	*	*	NFP
cord-006860-a3b8hyyr	1838	2	*	*	NFP
cord-006860-a3b8hyyr	1838	3	0,462	0,462	CD
cord-006860-a3b8hyyr	1839	1	*	*	NFP
cord-006860-a3b8hyyr	1839	2	*	*	NFP
cord-006860-a3b8hyyr	1839	3	triglycerides	triglyceride	NNS
cord-006860-a3b8hyyr	1839	4	0,452	0,452	CD
cord-006860-a3b8hyyr	1840	1	*	*	NFP
cord-006860-a3b8hyyr	1840	2	*	*	NFP
cord-006860-a3b8hyyr	1840	3	0,441	0,441	CD
cord-006860-a3b8hyyr	1841	1	*	*	NFP
cord-006860-a3b8hyyr	1841	2	*	*	NFP
cord-006860-a3b8hyyr	1841	3	total	total	JJ
cord-006860-a3b8hyyr	1841	4	cholesterol	cholesterol	NN
cord-006860-a3b8hyyr	1841	5	0,252	0,252	CD
cord-006860-a3b8hyyr	1842	1	*	*	NFP
cord-006860-a3b8hyyr	1842	2	*	*	NFP
cord-006860-a3b8hyyr	1842	3	0,255	0,255	CD
cord-006860-a3b8hyyr	1843	1	*	*	NFP
cord-006860-a3b8hyyr	1843	2	*	*	NFP
cord-006860-a3b8hyyr	1843	3	LDL	ldl	NN
cord-006860-a3b8hyyr	1843	4	-	-	HYPH
cord-006860-a3b8hyyr	1843	5	cholesterol	cholesterol	NN
cord-006860-a3b8hyyr	1843	6	0,263	0,263	CD
cord-006860-a3b8hyyr	1844	1	*	*	NFP
cord-006860-a3b8hyyr	1844	2	*	*	NFP
cord-006860-a3b8hyyr	1844	3	0,264	0,264	CD
cord-006860-a3b8hyyr	1845	1	*	*	NFP
cord-006860-a3b8hyyr	1845	2	*	*	NFP
cord-006860-a3b8hyyr	1845	3	HDL	hdl	NN
cord-006860-a3b8hyyr	1845	4	-	-	HYPH
cord-006860-a3b8hyyr	1845	5	cholesterol	cholesterol	NN
cord-006860-a3b8hyyr	1846	1	-0,357	-0,357	NNP
cord-006860-a3b8hyyr	1847	1	*	*	NFP
cord-006860-a3b8hyyr	1847	2	*	*	NFP
cord-006860-a3b8hyyr	1847	3	-0,355	-0,355	NNP
cord-006860-a3b8hyyr	1847	4	*	*	NFP
cord-006860-a3b8hyyr	1847	5	*	*	NFP
cord-006860-a3b8hyyr	1847	6	apolipoprotein	apolipoprotein	NN
cord-006860-a3b8hyyr	1847	7	B	B	NNP
cord-006860-a3b8hyyr	1847	8	0,428	0,428	CD
cord-006860-a3b8hyyr	1848	1	*	*	NFP
cord-006860-a3b8hyyr	1848	2	*	*	NFP
cord-006860-a3b8hyyr	1848	3	0,402	0,402	CD
cord-006860-a3b8hyyr	1849	1	*	*	NFP
cord-006860-a3b8hyyr	1849	2	*	*	NFP
cord-006860-a3b8hyyr	1849	3	apolipoprotein	apolipoprotein	NN
cord-006860-a3b8hyyr	1849	4	A	a	NN
cord-006860-a3b8hyyr	1850	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	1851	1	-0,233	-0,233	.
cord-006860-a3b8hyyr	1852	1	*	*	NFP
cord-006860-a3b8hyyr	1852	2	*	*	NFP
cord-006860-a3b8hyyr	1852	3	-0,211	-0,211	.
cord-006860-a3b8hyyr	1853	1	*	*	NFP
cord-006860-a3b8hyyr	1853	2	*	*	NFP
cord-006860-a3b8hyyr	1853	3	The	the	DT
cord-006860-a3b8hyyr	1853	4	lower	low	JJR
cord-006860-a3b8hyyr	1853	5	relationship	relationship	NN
cord-006860-a3b8hyyr	1853	6	of	of	IN
cord-006860-a3b8hyyr	1853	7	the	the	DT
cord-006860-a3b8hyyr	1853	8	whole	whole	JJ
cord-006860-a3b8hyyr	1853	9	PAt	pat	NN
cord-006860-a3b8hyyr	1853	10	antigen	antigen	NN
cord-006860-a3b8hyyr	1853	11	to	to	IN
cord-006860-a3b8hyyr	1853	12	t	t	NNP
cord-006860-a3b8hyyr	1853	13	-	-	HYPH
cord-006860-a3b8hyyr	1853	14	PA	PA	NNP
cord-006860-a3b8hyyr	1853	15	is	be	VBZ
cord-006860-a3b8hyyr	1853	16	obviously	obviously	RB
cord-006860-a3b8hyyr	1853	17	caused	cause	VBN
cord-006860-a3b8hyyr	1853	18	by	by	IN
cord-006860-a3b8hyyr	1853	19	patient	patient	JJ
cord-006860-a3b8hyyr	1853	20	samples	sample	NNS
cord-006860-a3b8hyyr	1853	21	with	with	IN
cord-006860-a3b8hyyr	1853	22	high	high	JJ
cord-006860-a3b8hyyr	1853	23	levels	level	NNS
cord-006860-a3b8hyyr	1853	24	of	of	IN
cord-006860-a3b8hyyr	1853	25	whole	whole	JJ
cord-006860-a3b8hyyr	1853	26	PAt	pat	NN
cord-006860-a3b8hyyr	1853	27	antigen	antigen	NN
cord-006860-a3b8hyyr	1853	28	in	in	IN
cord-006860-a3b8hyyr	1853	29	contrast	contrast	NN
cord-006860-a3b8hyyr	1853	30	to	to	IN
cord-006860-a3b8hyyr	1853	31	normal	normal	JJ
cord-006860-a3b8hyyr	1853	32	values	value	NNS
cord-006860-a3b8hyyr	1853	33	of	of	IN
cord-006860-a3b8hyyr	1853	34	active	active	JJ
cord-006860-a3b8hyyr	1853	35	PAt	PAt	NNS
cord-006860-a3b8hyyr	1853	36	as	as	IN
cord-006860-a3b8hyyr	1853	37	well'as	well'as	NN
cord-006860-a3b8hyyr	1853	38	of	of	IN
cord-006860-a3b8hyyr	1853	39	t	t	NNP
cord-006860-a3b8hyyr	1853	40	-	-	HYPH
cord-006860-a3b8hyyr	1853	41	PA	PA	NNP
cord-006860-a3b8hyyr	1853	42	.	.	.
cord-006860-a3b8hyyr	1854	1	Possibly	possibly	RB
cord-006860-a3b8hyyr	1854	2	,	,	,
cord-006860-a3b8hyyr	1854	3	a	a	DT
cord-006860-a3b8hyyr	1854	4	high	high	JJ
cord-006860-a3b8hyyr	1854	5	ratio	ratio	NN
cord-006860-a3b8hyyr	1854	6	of	of	IN
cord-006860-a3b8hyyr	1854	7	whole	whole	JJ
cord-006860-a3b8hyyr	1854	8	PAI	PAI	NNP
cord-006860-a3b8hyyr	1854	9	antigen	antigen	NN
cord-006860-a3b8hyyr	1854	10	/	/	SYM
cord-006860-a3b8hyyr	1854	11	active	active	JJ
cord-006860-a3b8hyyr	1854	12	PAt	pat	NN
cord-006860-a3b8hyyr	1854	13	antigen	antigen	NN
cord-006860-a3b8hyyr	1854	14	is	be	VBZ
cord-006860-a3b8hyyr	1854	15	caused	cause	VBN
cord-006860-a3b8hyyr	1854	16	by	by	IN
cord-006860-a3b8hyyr	1854	17	a	a	DT
cord-006860-a3b8hyyr	1854	18	raise	raise	NN
cord-006860-a3b8hyyr	1854	19	of	of	IN
cord-006860-a3b8hyyr	1854	20	latent	latent	JJ
cord-006860-a3b8hyyr	1854	21	PAL	pal	NN
cord-006860-a3b8hyyr	1854	22	the	the	DT
cord-006860-a3b8hyyr	1854	23	main	main	JJ
cord-006860-a3b8hyyr	1854	24	form	form	NN
cord-006860-a3b8hyyr	1854	25	of	of	IN
cord-006860-a3b8hyyr	1854	26	PAt	PAt	NNS
cord-006860-a3b8hyyr	1854	27	in	in	IN
cord-006860-a3b8hyyr	1854	28	the	the	DT
cord-006860-a3b8hyyr	1854	29	platelets	platelet	NNS
cord-006860-a3b8hyyr	1854	30	.	.	.
cord-006860-a3b8hyyr	1855	1	The	the	DT
cord-006860-a3b8hyyr	1855	2	clinical	clinical	JJ
cord-006860-a3b8hyyr	1855	3	importance	importance	NN
cord-006860-a3b8hyyr	1855	4	of	of	IN
cord-006860-a3b8hyyr	1855	5	an	an	DT
cord-006860-a3b8hyyr	1855	6	increased	increase	VBN
cord-006860-a3b8hyyr	1855	7	ratio	ratio	NN
cord-006860-a3b8hyyr	1855	8	whole	whole	JJ
cord-006860-a3b8hyyr	1855	9	PAl	PAl	NNS
cord-006860-a3b8hyyr	1855	10	antigen	antigen	NN
cord-006860-a3b8hyyr	1855	11	/	/	SYM
cord-006860-a3b8hyyr	1855	12	active	active	JJ
cord-006860-a3b8hyyr	1855	13	PAl	PAl	NNS
cord-006860-a3b8hyyr	1855	14	antigen	antigen	NN
cord-006860-a3b8hyyr	1855	15	remains	remain	VBZ
cord-006860-a3b8hyyr	1855	16	under	under	IN
cord-006860-a3b8hyyr	1855	17	investigation	investigation	NN
cord-006860-a3b8hyyr	1855	18	.	.	.
cord-006860-a3b8hyyr	1856	1	The	the	DT
cord-006860-a3b8hyyr	1856	2	cyclic	cyclic	JJ
cord-006860-a3b8hyyr	1856	3	antibiotics	antibiotic	NNS
cord-006860-a3b8hyyr	1856	4	-	-	:
cord-006860-a3b8hyyr	1856	5	polypeptides	polypeptide	NNS
cord-006860-a3b8hyyr	1857	1	Bacifracin	Bacifracin	NNP
cord-006860-a3b8hyyr	1857	2	A	A	NNP
cord-006860-a3b8hyyr	1857	3	,	,	,
cord-006860-a3b8hyyr	1857	4	Bacilliquin	Bacilliquin	NNP
cord-006860-a3b8hyyr	1857	5	from	from	IN
cord-006860-a3b8hyyr	1857	6	Boci	Boci	NNP
cord-006860-a3b8hyyr	1857	7	/	/	SYM
cord-006860-a3b8hyyr	1857	8	lu~	lu~	NN
cord-006860-a3b8hyyr	1857	9	,	,	,
cord-006860-a3b8hyyr	1857	10	licheniformis	licheniformis	NNP
cord-006860-a3b8hyyr	1857	11	and	and	CC
cord-006860-a3b8hyyr	1857	12	Gramicidin	Gramicidin	NNP
cord-006860-a3b8hyyr	1857	13	S	S	NNP
cord-006860-a3b8hyyr	1857	14	from	from	IN
cord-006860-a3b8hyyr	1857	15	Bocil	Bocil	NNP
cord-006860-a3b8hyyr	1857	16	/	/	SYM
cord-006860-a3b8hyyr	1857	17	us	us	NNP
cord-006860-a3b8hyyr	1857	18	brevis	brevis	NNP
cord-006860-a3b8hyyr	1857	19	,	,	,
cord-006860-a3b8hyyr	1857	20	var	var	NNP
cord-006860-a3b8hyyr	1857	21	.	.	.
cord-006860-a3b8hyyr	1858	1	(	(	-LRB-
cord-006860-a3b8hyyr	1858	2	3	3	CD
cord-006860-a3b8hyyr	1858	3	.	.	.
cord-006860-a3b8hyyr	1858	4	B.	B.	NNP
cord-006860-a3b8hyyr	1858	5	,	,	,
cord-006860-a3b8hyyr	1858	6	were	be	VBD
cord-006860-a3b8hyyr	1858	7	used	use	VBN
cord-006860-a3b8hyyr	1858	8	for	for	IN
cord-006860-a3b8hyyr	1858	9	investigation	investigation	NN
cord-006860-a3b8hyyr	1858	10	.	.	.
cord-006860-a3b8hyyr	1859	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1859	2	studied	study	VBD
cord-006860-a3b8hyyr	1859	3	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1859	4	influence	influence	NN
cord-006860-a3b8hyyr	1859	5	on	on	IN
cord-006860-a3b8hyyr	1859	6	the	the	DT
cord-006860-a3b8hyyr	1859	7	fibrinoly	fibrinoly	JJ
cord-006860-a3b8hyyr	1859	8	~	~	NFP
cord-006860-a3b8hyyr	1859	9	c	c	NN
cord-006860-a3b8hyyr	1859	10	and	and	CC
cord-006860-a3b8hyyr	1859	11	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1859	12	activity	activity	NN
cord-006860-a3b8hyyr	1859	13	in	in	IN
cord-006860-a3b8hyyr	1859	14	vitro•	vitro•	NN
cord-006860-a3b8hyyr	1860	1	Me	-PRON-	PRP
cord-006860-a3b8hyyr	1860	2	~	~	CD
cord-006860-a3b8hyyr	1860	3	hods	hod	NNS
cord-006860-a3b8hyyr	1860	4	.	.	.
cord-006860-a3b8hyyr	1861	1	To	to	IN
cord-006860-a3b8hyyr	1861	2	solution	solution	NN
cord-006860-a3b8hyyr	1861	3	of	of	IN
cord-006860-a3b8hyyr	1861	4	human	human	JJ
cord-006860-a3b8hyyr	1861	5	plasmin	plasmin	NN
cord-006860-a3b8hyyr	1861	6	(	(	-LRB-
cord-006860-a3b8hyyr	1861	7	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1861	8	)	)	-RRB-
cord-006860-a3b8hyyr	1861	9	.	.	.
cord-006860-a3b8hyyr	1862	1	containing	contain	VBG
cord-006860-a3b8hyyr	1862	2	0.2	0.2	CD
cord-006860-a3b8hyyr	1862	3	mg	mg	NN
cord-006860-a3b8hyyr	1862	4	of	of	IN
cord-006860-a3b8hyyr	1862	5	protein	protein	NN
cord-006860-a3b8hyyr	1862	6	(	(	-LRB-
cord-006860-a3b8hyyr	1862	7	1	1	CD
cord-006860-a3b8hyyr	1862	8	NIH	NIH	NNP
cord-006860-a3b8hyyr	1862	9	unff)/ml	unff)/ml	NN
cord-006860-a3b8hyyr	1862	10	,	,	,
cord-006860-a3b8hyyr	1862	11	the	the	DT
cord-006860-a3b8hyyr	1862	12	analyses	analysis	NNS
cord-006860-a3b8hyyr	1862	13	'	'	POS
cord-006860-a3b8hyyr	1862	14	solution	solution	NN
cord-006860-a3b8hyyr	1862	15	of	of	IN
cord-006860-a3b8hyyr	1862	16	antibiotics	antibiotic	NNS
cord-006860-a3b8hyyr	1862	17	(	(	-LRB-
cord-006860-a3b8hyyr	1862	18	0.1	0.1	CD
cord-006860-a3b8hyyr	1862	19	-	-	HYPH
cord-006860-a3b8hyyr	1862	20	8,0	8,0	CD
cord-006860-a3b8hyyr	1862	21	mg	mg	NNP
cord-006860-a3b8hyyr	1862	22	)	)	-RRB-
cord-006860-a3b8hyyr	1862	23	was	be	VBD
cord-006860-a3b8hyyr	1862	24	added	add	VBN
cord-006860-a3b8hyyr	1862	25	.	.	.
cord-006860-a3b8hyyr	1863	1	Then	then	RB
cord-006860-a3b8hyyr	1863	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	1863	3	defined	define	VBD
cord-006860-a3b8hyyr	1863	4	the	the	DT
cord-006860-a3b8hyyr	1863	5	tlbrinolytlc	tlbrinolytlc	NN
cord-006860-a3b8hyyr	1863	6	activity	activity	NN
cord-006860-a3b8hyyr	1863	7	of	of	IN
cord-006860-a3b8hyyr	1863	8	the	the	DT
cord-006860-a3b8hyyr	1863	9	mixes	mix	NNS
cord-006860-a3b8hyyr	1863	10	using	use	VBG
cord-006860-a3b8hyyr	1863	11	azofibrin	azofibrin	NNP
cord-006860-a3b8hyyr	1863	12	lysis	lysis	NN
cord-006860-a3b8hyyr	1863	13	,	,	,
cord-006860-a3b8hyyr	1863	14	and	and	CC
cord-006860-a3b8hyyr	1863	15	fhrombin	fhrombin	NN
cord-006860-a3b8hyyr	1863	16	activity	activity	NN
cord-006860-a3b8hyyr	1863	17	was	be	VBD
cord-006860-a3b8hyyr	1863	18	determined	determine	VBN
cord-006860-a3b8hyyr	1863	19	according	accord	VBG
cord-006860-a3b8hyyr	1863	20	to	to	IN
cord-006860-a3b8hyyr	1863	21	the	the	DT
cord-006860-a3b8hyyr	1863	22	speed	speed	NN
cord-006860-a3b8hyyr	1863	23	of	of	IN
cord-006860-a3b8hyyr	1863	24	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1863	25	clots	clot	NNS
cord-006860-a3b8hyyr	1863	26	formation	formation	NN
cord-006860-a3b8hyyr	1863	27	from	from	IN
cord-006860-a3b8hyyr	1863	28	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1863	29	solution	solution	NN
cord-006860-a3b8hyyr	1863	30	.	.	.
cord-006860-a3b8hyyr	1864	1	Results	result	NNS
cord-006860-a3b8hyyr	1864	2	.	.	.
cord-006860-a3b8hyyr	1865	1	In	in	IN
cord-006860-a3b8hyyr	1865	2	following	follow	VBG
cord-006860-a3b8hyyr	1865	3	table	table	NN
cord-006860-a3b8hyyr	1865	4	are	be	VBP
cord-006860-a3b8hyyr	1865	5	submifled	submifle	VBN
cord-006860-a3b8hyyr	1865	6	the	the	DT
cord-006860-a3b8hyyr	1865	7	results	result	NNS
cord-006860-a3b8hyyr	1865	8	received	receive	VBN
cord-006860-a3b8hyyr	1865	9	in	in	IN
cord-006860-a3b8hyyr	1865	10	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1865	11	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1865	12	{	{	-LRB-
cord-006860-a3b8hyyr	1865	13	we	-PRON-	PRP
cord-006860-a3b8hyyr	1865	14	also	also	RB
cord-006860-a3b8hyyr	1865	15	offer	offer	VBP
cord-006860-a3b8hyyr	1865	16	results	result	NNS
cord-006860-a3b8hyyr	1865	17	of	of	IN
cord-006860-a3b8hyyr	1865	18	antibiotics	antibiotic	NNS
cord-006860-a3b8hyyr	1865	19	influence	influence	NN
cord-006860-a3b8hyyr	1865	20	on	on	IN
cord-006860-a3b8hyyr	1865	21	urokinase	urokinase	NN
cord-006860-a3b8hyyr	1865	22	activity	activity	NN
cord-006860-a3b8hyyr	1865	23	)	)	-RRB-
cord-006860-a3b8hyyr	1865	24	:	:	:
cord-006860-a3b8hyyr	1866	1	Ki	Ki	NNP
cord-006860-a3b8hyyr	1866	2	,	,	,
cord-006860-a3b8hyyr	1866	3	mM	mM	NNP
cord-006860-a3b8hyyr	1866	4	Ki	Ki	NNP
cord-006860-a3b8hyyr	1866	5	--the	--the	DT
cord-006860-a3b8hyyr	1866	6	constant	constant	NN
cord-006860-a3b8hyyr	1866	7	of	of	IN
cord-006860-a3b8hyyr	1866	8	inhibition	inhibition	NN
cord-006860-a3b8hyyr	1866	9	.	.	.
cord-006860-a3b8hyyr	1867	1	N.	N.	NNP
cord-006860-a3b8hyyr	1867	2	D.	D.	NNP
cord-006860-a3b8hyyr	1867	3	~	~	NFP
cord-006860-a3b8hyyr	1867	4	in	in	IN
cord-006860-a3b8hyyr	1867	5	studied	study	VBN
cord-006860-a3b8hyyr	1867	6	lirnils	lirnil	NNS
cord-006860-a3b8hyyr	1867	7	the	the	DT
cord-006860-a3b8hyyr	1867	8	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	1867	9	's	's	POS
cord-006860-a3b8hyyr	1867	10	activity	activity	NN
cord-006860-a3b8hyyr	1867	11	was	be	VBD
cord-006860-a3b8hyyr	1867	12	not	not	RB
cord-006860-a3b8hyyr	1867	13	observed	observe	VBN
cord-006860-a3b8hyyr	1867	14	.	.	.
cord-006860-a3b8hyyr	1868	1	---the	---the	DT
cord-006860-a3b8hyyr	1869	1	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	1869	2	's	's	POS
cord-006860-a3b8hyyr	1869	3	activity	activity	NN
cord-006860-a3b8hyyr	1869	4	was	be	VBD
cord-006860-a3b8hyyr	1869	5	not	not	RB
cord-006860-a3b8hyyr	1869	6	define	define	VB
cord-006860-a3b8hyyr	1869	7	.	.	.
cord-006860-a3b8hyyr	1870	1	I.	I.	NNP
cord-006860-a3b8hyyr	1870	2	--the	--the	ADD
cord-006860-a3b8hyyr	1871	1	inhibitor%	inhibitor%	NNP
cord-006860-a3b8hyyr	1871	2	activity	activity	NNP
cord-006860-a3b8hyyr	1871	3	was	be	VBD
cord-006860-a3b8hyyr	1871	4	observed	observe	VBN
cord-006860-a3b8hyyr	1871	5	but	but	CC
cord-006860-a3b8hyyr	1871	6	Ki	Ki	NNP
cord-006860-a3b8hyyr	1871	7	not	not	RB
cord-006860-a3b8hyyr	1871	8	determined	determine	VBN
cord-006860-a3b8hyyr	1871	9	.	.	.
cord-006860-a3b8hyyr	1872	1	+	+	CC
cord-006860-a3b8hyyr	1873	1	,	,	,
cord-006860-a3b8hyyr	1873	2	+	+	CD
cord-006860-a3b8hyyr	1873	3	%	%	NN
cord-006860-a3b8hyyr	1874	1	+	+	CC
cord-006860-a3b8hyyr	1875	1	+	+	CC
cord-006860-a3b8hyyr	1876	1	+	+	CC
cord-006860-a3b8hyyr	1876	2	--effect	--effect	NN
cord-006860-a3b8hyyr	1876	3	of	of	IN
cord-006860-a3b8hyyr	1876	4	inhibffion	inhibffion	NNP
cord-006860-a3b8hyyr	1876	5	(	(	-LRB-
cord-006860-a3b8hyyr	1876	6	in	in	IN
cord-006860-a3b8hyyr	1876	7	rela*iive	rela*iive	CD
cord-006860-a3b8hyyr	1876	8	indexes	index	NNS
cord-006860-a3b8hyyr	1876	9	)	)	-RRB-
cord-006860-a3b8hyyr	1876	10	.	.	.
cord-006860-a3b8hyyr	1877	1	Conc	Conc	NNP
cord-006860-a3b8hyyr	1877	2	/	/	SYM
cord-006860-a3b8hyyr	1877	3	us/	us/	NN
cord-006860-a3b8hyyr	1878	1	on.~	on.~	NNP
cord-006860-a3b8hyyr	1878	2	The	the	DT
cord-006860-a3b8hyyr	1878	3	results	result	NNS
cord-006860-a3b8hyyr	1878	4	received	receive	VBN
cord-006860-a3b8hyyr	1878	5	by	by	IN
cord-006860-a3b8hyyr	1878	6	us	-PRON-	PRP
cord-006860-a3b8hyyr	1878	7	testify	testify	VB
cord-006860-a3b8hyyr	1878	8	to	to	IN
cord-006860-a3b8hyyr	1878	9	the	the	DT
cord-006860-a3b8hyyr	1878	10	necessity	necessity	NN
cord-006860-a3b8hyyr	1878	11	of	of	IN
cord-006860-a3b8hyyr	1878	12	cautious	cautious	JJ
cord-006860-a3b8hyyr	1878	13	approach	approach	NN
cord-006860-a3b8hyyr	1878	14	to	to	IN
cord-006860-a3b8hyyr	1878	15	the	the	DT
cord-006860-a3b8hyyr	1878	16	use	use	NN
cord-006860-a3b8hyyr	1878	17	of	of	IN
cord-006860-a3b8hyyr	1878	18	antibiofics	antibiofic	NNS
cord-006860-a3b8hyyr	1878	19	-	-	:
cord-006860-a3b8hyyr	1878	20	polypeptides	polypeptide	NNS
cord-006860-a3b8hyyr	1878	21	for	for	IN
cord-006860-a3b8hyyr	1878	22	various	various	JJ
cord-006860-a3b8hyyr	1878	23	sorts	sort	NNS
cord-006860-a3b8hyyr	1878	24	of	of	IN
cord-006860-a3b8hyyr	1878	25	therapy	therapy	NN
cord-006860-a3b8hyyr	1878	26	in	in	IN
cord-006860-a3b8hyyr	1878	27	view	view	NN
cord-006860-a3b8hyyr	1878	28	of	of	IN
cord-006860-a3b8hyyr	1878	29	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1878	30	possible	possible	JJ
cord-006860-a3b8hyyr	1878	31	influence	influence	NN
cord-006860-a3b8hyyr	1878	32	on	on	IN
cord-006860-a3b8hyyr	1878	33	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1878	34	and	and	CC
cord-006860-a3b8hyyr	1878	35	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1878	36	actlvlfy	actlvlfy	NNS
cord-006860-a3b8hyyr	1878	37	,	,	,
cord-006860-a3b8hyyr	1878	38	of	of	IN
cord-006860-a3b8hyyr	1878	39	the	the	DT
cord-006860-a3b8hyyr	1878	40	organism	organism	NN
cord-006860-a3b8hyyr	1878	41	.	.	.
cord-006860-a3b8hyyr	1879	1	These	these	DT
cord-006860-a3b8hyyr	1879	2	results	result	NNS
cord-006860-a3b8hyyr	1879	3	were	be	VBD
cord-006860-a3b8hyyr	1879	4	used	use	VBN
cord-006860-a3b8hyyr	1879	5	for	for	IN
cord-006860-a3b8hyyr	1879	6	preparation	preparation	NN
cord-006860-a3b8hyyr	1879	7	in	in	IN
cord-006860-a3b8hyyr	1879	8	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1879	9	laboratory	laboratory	NN
cord-006860-a3b8hyyr	1879	10	of	of	IN
cord-006860-a3b8hyyr	1879	11	biospeciflc	biospeciflc	NNP
cord-006860-a3b8hyyr	1879	12	sorbents	sorbent	NNS
cord-006860-a3b8hyyr	1879	13	containing	contain	VBG
cord-006860-a3b8hyyr	1879	14	C	C	NNP
cord-006860-a3b8hyyr	1879	15	-	-	HYPH
cord-006860-a3b8hyyr	1879	16	ramicidin	ramicidin	NNP
cord-006860-a3b8hyyr	1879	17	A	A	NNP
cord-006860-a3b8hyyr	1879	18	,	,	,
cord-006860-a3b8hyyr	1879	19	Bacil}iquirt	Bacil}iquirt	NNP
cord-006860-a3b8hyyr	1879	20	and	and	CC
cord-006860-a3b8hyyr	1879	21	Gramicidin	Gramicidin	NNP
cord-006860-a3b8hyyr	1880	1	S.as	s.as	CD
cord-006860-a3b8hyyr	1880	2	ligands	ligand	NNS
cord-006860-a3b8hyyr	1880	3	,	,	,
cord-006860-a3b8hyyr	1880	4	They	-PRON-	PRP
cord-006860-a3b8hyyr	1880	5	can	can	MD
cord-006860-a3b8hyyr	1880	6	reversibly	reversibly	RB
cord-006860-a3b8hyyr	1880	7	bind	bind	VB
cord-006860-a3b8hyyr	1880	8	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1880	9	,	,	,
cord-006860-a3b8hyyr	1880	10	plasmin	plasmin	NNP
cord-006860-a3b8hyyr	1880	11	{	{	-LRB-
cord-006860-a3b8hyyr	1880	12	plosminogen	plosminogen	NNP
cord-006860-a3b8hyyr	1880	13	)	)	-RRB-
cord-006860-a3b8hyyr	1880	14	and	and	CC
cord-006860-a3b8hyyr	1880	15	urokinase	urokinase	NN
cord-006860-a3b8hyyr	1880	16	directly	directly	RB
cord-006860-a3b8hyyr	1880	17	from	from	IN
cord-006860-a3b8hyyr	1880	18	crude	crude	JJ
cord-006860-a3b8hyyr	1880	19	exkacts	exkact	NNS
cord-006860-a3b8hyyr	1880	20	.	.	.
cord-006860-a3b8hyyr	1881	1	The	the	DT
cord-006860-a3b8hyyr	1881	2	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	1881	3	are	be	VBP
cord-006860-a3b8hyyr	1881	4	selectively	selectively	RB
cord-006860-a3b8hyyr	1881	5	eluted	elute	VBN
cord-006860-a3b8hyyr	1881	6	without	without	IN
cord-006860-a3b8hyyr	1881	7	substantial	substantial	JJ
cord-006860-a3b8hyyr	1881	8	losses	loss	NNS
cord-006860-a3b8hyyr	1881	9	of	of	IN
cord-006860-a3b8hyyr	1881	10	specific	specific	JJ
cord-006860-a3b8hyyr	1881	11	activity	activity	NN
cord-006860-a3b8hyyr	1881	12	in	in	IN
cord-006860-a3b8hyyr	1881	13	e	e	CD
cord-006860-a3b8hyyr	1881	14	yield	yield	NN
cord-006860-a3b8hyyr	1881	15	of	of	IN
cord-006860-a3b8hyyr	1881	16	60	60	CD
cord-006860-a3b8hyyr	1881	17	-	-	SYM
cord-006860-a3b8hyyr	1881	18	90	90	CD
cord-006860-a3b8hyyr	1881	19	%	%	NN
cord-006860-a3b8hyyr	1881	20	.	.	.
cord-006860-a3b8hyyr	1882	1	There	there	EX
cord-006860-a3b8hyyr	1882	2	is	be	VBZ
cord-006860-a3b8hyyr	1882	3	a	a	DT
cord-006860-a3b8hyyr	1882	4	great	great	JJ
cord-006860-a3b8hyyr	1882	5	body	body	NN
cord-006860-a3b8hyyr	1882	6	of	of	IN
cord-006860-a3b8hyyr	1882	7	rather	rather	RB
cord-006860-a3b8hyyr	1882	8	contradictory	contradictory	JJ
cord-006860-a3b8hyyr	1882	9	informations	information	NNS
cord-006860-a3b8hyyr	1882	10	dealing	deal	VBG
cord-006860-a3b8hyyr	1882	11	with	with	IN
cord-006860-a3b8hyyr	1882	12	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1882	13	in	in	IN
cord-006860-a3b8hyyr	1882	14	liver	liver	NN
cord-006860-a3b8hyyr	1882	15	..	..	.
cord-006860-a3b8hyyr	1883	1	cirrhosis	cirrhosis	NN
cord-006860-a3b8hyyr	1883	2	,	,	,
cord-006860-a3b8hyyr	1883	3	which	which	WDT
cord-006860-a3b8hyyr	1883	4	can	can	MD
cord-006860-a3b8hyyr	1883	5	be	be	VB
cord-006860-a3b8hyyr	1883	6	accelerated	accelerate	VBN
cord-006860-a3b8hyyr	1883	7	,	,	,
cord-006860-a3b8hyyr	1883	8	normal	normal	JJ
cord-006860-a3b8hyyr	1883	9	or	or	CC
cord-006860-a3b8hyyr	1883	10	reduced	reduced	JJ
cord-006860-a3b8hyyr	1883	11	,	,	,
cord-006860-a3b8hyyr	1883	12	depending	depend	VBG
cord-006860-a3b8hyyr	1883	13	on	on	IN
cord-006860-a3b8hyyr	1883	14	the	the	DT
cord-006860-a3b8hyyr	1883	15	type	type	NN
cord-006860-a3b8hyyr	1883	16	of	of	IN
cord-006860-a3b8hyyr	1883	17	cirrhosis	cirrhosis	NN
cord-006860-a3b8hyyr	1883	18	and	and	CC
cord-006860-a3b8hyyr	1883	19	investigation	investigation	NN
cord-006860-a3b8hyyr	1883	20	techniques	technique	NNS
cord-006860-a3b8hyyr	1883	21	(	(	-LRB-
cord-006860-a3b8hyyr	1883	22	clot	clot	NN
cord-006860-a3b8hyyr	1883	23	-	-	HYPH
cord-006860-a3b8hyyr	1883	24	lysis	lysis	NN
cord-006860-a3b8hyyr	1883	25	,	,	,
cord-006860-a3b8hyyr	1883	26	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1883	27	component	component	NN
cord-006860-a3b8hyyr	1883	28	measurements	measurement	NNS
cord-006860-a3b8hyyr	1883	29	)	)	-RRB-
cord-006860-a3b8hyyr	1883	30	.	.	.
cord-006860-a3b8hyyr	1884	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	1884	2	previous	previous	JJ
cord-006860-a3b8hyyr	1884	3	finding	finding	NN
cord-006860-a3b8hyyr	1884	4	was	be	VBD
cord-006860-a3b8hyyr	1884	5	,	,	,
cord-006860-a3b8hyyr	1884	6	that	that	IN
cord-006860-a3b8hyyr	1884	7	in	in	IN
cord-006860-a3b8hyyr	1884	8	vitro	vitro	FW
cord-006860-a3b8hyyr	1884	9	plasma	plasma	NN
cord-006860-a3b8hyyr	1884	10	-	-	HYPH
cord-006860-a3b8hyyr	1884	11	clot	clot	NN
cord-006860-a3b8hyyr	1884	12	lysis	lysis	NN
cord-006860-a3b8hyyr	1884	13	,	,	,
cord-006860-a3b8hyyr	1884	14	induced	induce	VBN
cord-006860-a3b8hyyr	1884	15	by	by	IN
cord-006860-a3b8hyyr	1884	16	exogeneously	exogeneously	NNP
cord-006860-a3b8hyyr	1884	17	added	add	VBN
cord-006860-a3b8hyyr	1884	18	tPA	tPA	NNP
cord-006860-a3b8hyyr	1884	19	or	or	CC
cord-006860-a3b8hyyr	1884	20	streptokinase	streptokinase	NNP
cord-006860-a3b8hyyr	1884	21	proved	prove	VBD
cord-006860-a3b8hyyr	1884	22	to	to	TO
cord-006860-a3b8hyyr	1884	23	be	be	VB
cord-006860-a3b8hyyr	1884	24	reduced	reduce	VBN
cord-006860-a3b8hyyr	1884	25	,	,	,
cord-006860-a3b8hyyr	1884	26	and	and	CC
cord-006860-a3b8hyyr	1884	27	this	this	DT
cord-006860-a3b8hyyr	1884	28	had	have	VBD
cord-006860-a3b8hyyr	1884	29	a	a	DT
cord-006860-a3b8hyyr	1884	30	good	good	JJ
cord-006860-a3b8hyyr	1884	31	correlation	correlation	NN
cord-006860-a3b8hyyr	1884	32	with	with	IN
cord-006860-a3b8hyyr	1884	33	severity	severity	NN
cord-006860-a3b8hyyr	1884	34	of	of	IN
cord-006860-a3b8hyyr	1884	35	the	the	DT
cord-006860-a3b8hyyr	1884	36	disease	disease	NN
cord-006860-a3b8hyyr	1884	37	and	and	CC
cord-006860-a3b8hyyr	1884	38	the	the	DT
cord-006860-a3b8hyyr	1884	39	elevation	elevation	NN
cord-006860-a3b8hyyr	1884	40	of	of	IN
cord-006860-a3b8hyyr	1884	41	plasmatic	plasmatic	NNP
cord-006860-a3b8hyyr	1884	42	yon	yon	NNP
cord-006860-a3b8hyyr	1884	43	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	1884	44	factor	factor	NN
cord-006860-a3b8hyyr	1884	45	levels	level	NNS
cord-006860-a3b8hyyr	1884	46	.	.	.
cord-006860-a3b8hyyr	1885	1	In	in	IN
cord-006860-a3b8hyyr	1885	2	vitro	vitro	FW
cord-006860-a3b8hyyr	1885	3	clo~/-	clo~/-	FW
cord-006860-a3b8hyyr	1885	4	[	[	-LRB-
cord-006860-a3b8hyyr	1885	5	lysis	lysis	NN
cord-006860-a3b8hyyr	1885	6	tests	test	NNS
cord-006860-a3b8hyyr	1885	7	,	,	,
cord-006860-a3b8hyyr	1885	8	induced	induce	VBN
cord-006860-a3b8hyyr	1885	9	by	by	IN
cord-006860-a3b8hyyr	1885	10	tPA	tPA	NNP
cord-006860-a3b8hyyr	1885	11	were	be	VBD
cord-006860-a3b8hyyr	1885	12	performed	perform	VBN
cord-006860-a3b8hyyr	1885	13	in	in	IN
cord-006860-a3b8hyyr	1885	14	41	41	CD
cord-006860-a3b8hyyr	1885	15	patients	patient	NNS
cord-006860-a3b8hyyr	1885	16	with	with	IN
cord-006860-a3b8hyyr	1885	17	alcoholic	alcoholic	JJ
cord-006860-a3b8hyyr	1885	18	liver	liver	NN
cord-006860-a3b8hyyr	1885	19	cirrhosis	cirrhosis	NN
cord-006860-a3b8hyyr	1885	20	,	,	,
cord-006860-a3b8hyyr	1885	21	utilising	utilise	VBG
cord-006860-a3b8hyyr	1885	22	a	a	DT
cord-006860-a3b8hyyr	1885	23	microplate	microplate	JJ
cord-006860-a3b8hyyr	1885	24	light	light	NN
cord-006860-a3b8hyyr	1885	25	-	-	HYPH
cord-006860-a3b8hyyr	1885	26	scattering	scatter	VBG
cord-006860-a3b8hyyr	1885	27	assessment	assessment	NN
cord-006860-a3b8hyyr	1885	28	method	method	NN
cord-006860-a3b8hyyr	1885	29	.	.	.
cord-006860-a3b8hyyr	1886	1	The	the	DT
cord-006860-a3b8hyyr	1886	2	tests	test	NNS
cord-006860-a3b8hyyr	1886	3	were	be	VBD
cord-006860-a3b8hyyr	1886	4	repeated	repeat	VBN
cord-006860-a3b8hyyr	1886	5	using	use	VBG
cord-006860-a3b8hyyr	1886	6	the	the	DT
cord-006860-a3b8hyyr	1886	7	same	same	JJ
cord-006860-a3b8hyyr	1886	8	plasma	plasma	NN
cord-006860-a3b8hyyr	1886	9	samples	sample	NNS
cord-006860-a3b8hyyr	1886	10	in	in	IN
cord-006860-a3b8hyyr	1886	11	each	each	DT
cord-006860-a3b8hyyr	1886	12	patients	patient	NNS
cord-006860-a3b8hyyr	1886	13	with	with	IN
cord-006860-a3b8hyyr	1886	14	a	a	DT
cord-006860-a3b8hyyr	1886	15	microplate	microplate	NN
cord-006860-a3b8hyyr	1886	16	which	which	WDT
cord-006860-a3b8hyyr	1886	17	was	be	VBD
cord-006860-a3b8hyyr	1886	18	covered	cover	VBN
cord-006860-a3b8hyyr	1886	19	by	by	IN
cord-006860-a3b8hyyr	1886	20	cultured	cultured	JJ
cord-006860-a3b8hyyr	1886	21	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1886	22	-	-	HYPH
cord-006860-a3b8hyyr	1886	23	cell	cell	NN
cord-006860-a3b8hyyr	1886	24	monolayer	monolayer	NN
cord-006860-a3b8hyyr	1886	25	(	(	-LRB-
cord-006860-a3b8hyyr	1886	26	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	1886	27	vein	vein	NN
cord-006860-a3b8hyyr	1886	28	,	,	,
cord-006860-a3b8hyyr	1886	29	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	1886	30	}	}	-RRB-
cord-006860-a3b8hyyr	1886	31	.	.	.
cord-006860-a3b8hyyr	1887	1	Clot	clot	NN
cord-006860-a3b8hyyr	1887	2	lysis	lysis	NN
cord-006860-a3b8hyyr	1887	3	speed	speed	NN
cord-006860-a3b8hyyr	1887	4	proved	prove	VBN
cord-006860-a3b8hyyr	1887	5	to	to	TO
cord-006860-a3b8hyyr	1887	6	be	be	VB
cord-006860-a3b8hyyr	1887	7	1.5	1.5	CD
cord-006860-a3b8hyyr	1887	8	-	-	SYM
cord-006860-a3b8hyyr	1887	9	2	2	CD
cord-006860-a3b8hyyr	1887	10	times	time	NNS
cord-006860-a3b8hyyr	1887	11	slower	slow	JJR
cord-006860-a3b8hyyr	1887	12	with	with	IN
cord-006860-a3b8hyyr	1887	13	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	1887	14	milieu	milieu	NN
cord-006860-a3b8hyyr	1887	15	in	in	IN
cord-006860-a3b8hyyr	1887	16	the	the	DT
cord-006860-a3b8hyyr	1887	17	control	control	NN
cord-006860-a3b8hyyr	1887	18	group	group	NN
cord-006860-a3b8hyyr	1887	19	,	,	,
cord-006860-a3b8hyyr	1887	20	while	while	IN
cord-006860-a3b8hyyr	1887	21	in	in	IN
cord-006860-a3b8hyyr	1887	22	the	the	DT
cord-006860-a3b8hyyr	1887	23	cirrhotic	cirrhotic	JJ
cord-006860-a3b8hyyr	1887	24	patients	patient	NNS
cord-006860-a3b8hyyr	1887	25	this	this	DT
cord-006860-a3b8hyyr	1887	26	inhibition	inhibition	NN
cord-006860-a3b8hyyr	1887	27	was	be	VBD
cord-006860-a3b8hyyr	1887	28	stronger	strong	JJR
cord-006860-a3b8hyyr	1887	29	and	and	CC
cord-006860-a3b8hyyr	1887	30	resulted	result	VBD
cord-006860-a3b8hyyr	1887	31	in	in	IN
cord-006860-a3b8hyyr	1887	32	5-fold	5-fold	CD
cord-006860-a3b8hyyr	1887	33	reduction	reduction	NN
cord-006860-a3b8hyyr	1887	34	of	of	IN
cord-006860-a3b8hyyr	1887	35	lysis	lysis	NN
cord-006860-a3b8hyyr	1887	36	speed	speed	NN
cord-006860-a3b8hyyr	1887	37	.	.	.
cord-006860-a3b8hyyr	1888	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	1888	2	results	result	NNS
cord-006860-a3b8hyyr	1888	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	1888	4	,	,	,
cord-006860-a3b8hyyr	1888	5	that	that	IN
cord-006860-a3b8hyyr	1888	6	cirrhotic	cirrhotic	JJ
cord-006860-a3b8hyyr	1888	7	plasma	plasma	NN
cord-006860-a3b8hyyr	1888	8	is	be	VBZ
cord-006860-a3b8hyyr	1888	9	able	able	JJ
cord-006860-a3b8hyyr	1888	10	to	to	TO
cord-006860-a3b8hyyr	1888	11	accelerate	accelerate	VB
cord-006860-a3b8hyyr	1888	12	the	the	DT
cord-006860-a3b8hyyr	1888	13	release	release	NN
cord-006860-a3b8hyyr	1888	14	of	of	IN
cord-006860-a3b8hyyr	1888	15	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1888	16	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1888	17	from	from	IN
cord-006860-a3b8hyyr	1888	18	cultured	cultured	JJ
cord-006860-a3b8hyyr	1888	19	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	1888	20	cells	cell	NNS
cord-006860-a3b8hyyr	1888	21	,	,	,
cord-006860-a3b8hyyr	1888	22	which	which	WDT
cord-006860-a3b8hyyr	1888	23	phenomenon	phenomenon	NN
cord-006860-a3b8hyyr	1888	24	may	may	MD
cord-006860-a3b8hyyr	1888	25	also	also	RB
cord-006860-a3b8hyyr	1888	26	contribute	contribute	VB
cord-006860-a3b8hyyr	1888	27	to	to	IN
cord-006860-a3b8hyyr	1888	28	the	the	DT
cord-006860-a3b8hyyr	1888	29	complex	complex	JJ
cord-006860-a3b8hyyr	1888	30	alterations	alteration	NNS
cord-006860-a3b8hyyr	1888	31	of	of	IN
cord-006860-a3b8hyyr	1888	32	in	in	IN
cord-006860-a3b8hyyr	1888	33	vivo	vivo	FW
cord-006860-a3b8hyyr	1888	34	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1888	35	in	in	IN
cord-006860-a3b8hyyr	1888	36	cirrhotic	cirrhotic	JJ
cord-006860-a3b8hyyr	1888	37	patients	patient	NNS
cord-006860-a3b8hyyr	1888	38	.	.	.
cord-006860-a3b8hyyr	1889	1	Deep	deep	JJ
cord-006860-a3b8hyyr	1889	2	vein	vein	NN
cord-006860-a3b8hyyr	1889	3	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	1889	4	(	(	-LRB-
cord-006860-a3b8hyyr	1889	5	DVT	DVT	NNP
cord-006860-a3b8hyyr	1889	6	)	)	-RRB-
cord-006860-a3b8hyyr	1889	7	is	be	VBZ
cord-006860-a3b8hyyr	1889	8	a	a	DT
cord-006860-a3b8hyyr	1889	9	systemic	systemic	JJ
cord-006860-a3b8hyyr	1889	10	disease	disease	NN
cord-006860-a3b8hyyr	1889	11	with	with	IN
cord-006860-a3b8hyyr	1889	12	prolonged	prolong	VBN
cord-006860-a3b8hyyr	1889	13	clinical	clinical	JJ
cord-006860-a3b8hyyr	1889	14	manifectation	manifectation	NN
cord-006860-a3b8hyyr	1889	15	.	.	.
cord-006860-a3b8hyyr	1890	1	Anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	1890	2	therapy	therapy	NN
cord-006860-a3b8hyyr	1890	3	in	in	IN
cord-006860-a3b8hyyr	1890	4	DVT	DVT	NNP
cord-006860-a3b8hyyr	1890	5	is	be	VBZ
cord-006860-a3b8hyyr	1890	6	not	not	RB
cord-006860-a3b8hyyr	1890	7	completely	completely	RB
cord-006860-a3b8hyyr	1890	8	effective	effective	JJ
cord-006860-a3b8hyyr	1890	9	.	.	.
cord-006860-a3b8hyyr	1891	1	Thrombolytic	thrombolytic	JJ
cord-006860-a3b8hyyr	1891	2	therapy	therapy	NN
cord-006860-a3b8hyyr	1891	3	may	may	MD
cord-006860-a3b8hyyr	1891	4	give	give	VB
cord-006860-a3b8hyyr	1891	5	rise	rise	NN
cord-006860-a3b8hyyr	1891	6	to	to	IN
cord-006860-a3b8hyyr	1891	7	a	a	DT
cord-006860-a3b8hyyr	1891	8	systemic	systemic	JJ
cord-006860-a3b8hyyr	1891	9	lytic	lytic	JJ
cord-006860-a3b8hyyr	1891	10	state	state	NN
cord-006860-a3b8hyyr	1891	11	,	,	,
cord-006860-a3b8hyyr	1891	12	The	the	DT
cord-006860-a3b8hyyr	1891	13	fibrinospesific	fibrinospesific	JJ
cord-006860-a3b8hyyr	1891	14	agents	agent	NNS
cord-006860-a3b8hyyr	1891	15	(	(	-LRB-
cord-006860-a3b8hyyr	1891	16	scu	scu	NNP
cord-006860-a3b8hyyr	1891	17	-	-	HYPH
cord-006860-a3b8hyyr	1891	18	PA	PA	NNP
cord-006860-a3b8hyyr	1891	19	and	and	CC
cord-006860-a3b8hyyr	1891	20	t	t	NNP
cord-006860-a3b8hyyr	1891	21	-	-	HYPH
cord-006860-a3b8hyyr	1891	22	PA	PA	NNP
cord-006860-a3b8hyyr	1891	23	)	)	-RRB-
cord-006860-a3b8hyyr	1891	24	have	have	VBP
cord-006860-a3b8hyyr	1891	25	short	short	JJ
cord-006860-a3b8hyyr	1891	26	half	half	RB
cord-006860-a3b8hyyr	1891	27	-	-	HYPH
cord-006860-a3b8hyyr	1891	28	lives	life	NNS
cord-006860-a3b8hyyr	1891	29	in	in	IN
cord-006860-a3b8hyyr	1891	30	the	the	DT
cord-006860-a3b8hyyr	1891	31	circulation	circulation	NN
cord-006860-a3b8hyyr	1891	32	.	.	.
cord-006860-a3b8hyyr	1892	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1892	2	investigated	investigate	VBD
cord-006860-a3b8hyyr	1892	3	the	the	DT
cord-006860-a3b8hyyr	1892	4	potency	potency	NN
cord-006860-a3b8hyyr	1892	5	of	of	IN
cord-006860-a3b8hyyr	1892	6	the	the	DT
cord-006860-a3b8hyyr	1892	7	acylated	acylated	JJ
cord-006860-a3b8hyyr	1892	8	plasminogen	plasminogen	NNP
cord-006860-a3b8hyyr	1892	9	streptokinase	streptokinase	NNP
cord-006860-a3b8hyyr	1892	10	activator	activator	NN
cord-006860-a3b8hyyr	1892	11	complex	complex	NN
cord-006860-a3b8hyyr	1892	12	(	(	-LRB-
cord-006860-a3b8hyyr	1892	13	GBPg	GBPg	NNP
cord-006860-a3b8hyyr	1892	14	-	-	HYPH
cord-006860-a3b8hyyr	1892	15	SK	SK	NNP
cord-006860-a3b8hyyr	1892	16	)	)	-RRB-
cord-006860-a3b8hyyr	1892	17	to	to	IN
cord-006860-a3b8hyyr	1892	18	deep	deep	JJ
cord-006860-a3b8hyyr	1892	19	vein	vein	NN
cord-006860-a3b8hyyr	1892	20	clot	clot	NN
cord-006860-a3b8hyyr	1892	21	dissolution	dissolution	NN
cord-006860-a3b8hyyr	1892	22	as	as	IN
cord-006860-a3b8hyyr	1892	23	compared	compare	VBN
cord-006860-a3b8hyyr	1892	24	to	to	IN
cord-006860-a3b8hyyr	1892	25	well	well	RB
cord-006860-a3b8hyyr	1892	26	known	know	VBN
cord-006860-a3b8hyyr	1892	27	SK	SK	NNP
cord-006860-a3b8hyyr	1892	28	and	and	CC
cord-006860-a3b8hyyr	1892	29	APSAC	APSAC	NNP
cord-006860-a3b8hyyr	1892	30	both	both	DT
cord-006860-a3b8hyyr	1892	31	in	in	IN
cord-006860-a3b8hyyr	1892	32	v	v	NN
cord-006860-a3b8hyyr	1892	33	~	~	NFP
cord-006860-a3b8hyyr	1892	34	tro	tro	NNP
cord-006860-a3b8hyyr	1892	35	and	and	CC
cord-006860-a3b8hyyr	1892	36	in	in	IN
cord-006860-a3b8hyyr	1892	37	vivo	vivo	NN
cord-006860-a3b8hyyr	1892	38	in	in	IN
cord-006860-a3b8hyyr	1892	39	the	the	DT
cord-006860-a3b8hyyr	1892	40	model	model	NN
cord-006860-a3b8hyyr	1892	41	of	of	IN
cord-006860-a3b8hyyr	1892	42	venous	venous	JJ
cord-006860-a3b8hyyr	1892	43	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	1892	44	in	in	IN
cord-006860-a3b8hyyr	1892	45	artherio	artherio	NN
cord-006860-a3b8hyyr	1892	46	-	-	HYPH
cord-006860-a3b8hyyr	1892	47	venous	venous	JJ
cord-006860-a3b8hyyr	1892	48	shunt	shunt	NN
cord-006860-a3b8hyyr	1892	49	in	in	IN
cord-006860-a3b8hyyr	1892	50	rats	rat	NNS
cord-006860-a3b8hyyr	1892	51	.	.	.
cord-006860-a3b8hyyr	1893	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1893	2	was	be	VBD
cord-006860-a3b8hyyr	1893	3	shown	show	VBN
cord-006860-a3b8hyyr	1893	4	in	in	RP
cord-006860-a3b8hyyr	1893	5	in	in	IN
cord-006860-a3b8hyyr	1893	6	vitro	vitro	FW
cord-006860-a3b8hyyr	1893	7	study	study	NN
cord-006860-a3b8hyyr	1893	8	that	that	IN
cord-006860-a3b8hyyr	1893	9	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1893	10	activity	activity	NN
cord-006860-a3b8hyyr	1893	11	of	of	IN
cord-006860-a3b8hyyr	1893	12	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	1893	13	activators	activator	NNS
cord-006860-a3b8hyyr	1893	14	mainly	mainly	RB
cord-006860-a3b8hyyr	1893	15	depends	depend	VBZ
cord-006860-a3b8hyyr	1893	16	on	on	IN
cord-006860-a3b8hyyr	1893	17	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1893	18	stability	stability	NN
cord-006860-a3b8hyyr	1893	19	in	in	IN
cord-006860-a3b8hyyr	1893	20	plasma	plasma	NN
cord-006860-a3b8hyyr	1893	21	.	.	.
cord-006860-a3b8hyyr	1894	1	Stability	stability	NN
cord-006860-a3b8hyyr	1894	2	studies	study	NNS
cord-006860-a3b8hyyr	1894	3	carried	carry	VBN
cord-006860-a3b8hyyr	1894	4	out	out	RP
cord-006860-a3b8hyyr	1894	5	by	by	IN
cord-006860-a3b8hyyr	1894	6	incubating	incubate	VBG
cord-006860-a3b8hyyr	1894	7	SK	SK	NNP
cord-006860-a3b8hyyr	1894	8	and	and	CC
cord-006860-a3b8hyyr	1894	9	Pg	Pg	NNP
cord-006860-a3b8hyyr	1894	10	-	-	HYPH
cord-006860-a3b8hyyr	1894	11	SK	SK	NNP
cord-006860-a3b8hyyr	1894	12	activator	activator	NN
cord-006860-a3b8hyyr	1894	13	complexes	complex	NNS
cord-006860-a3b8hyyr	1894	14	in	in	IN
cord-006860-a3b8hyyr	1894	15	plasma	plasma	NN
cord-006860-a3b8hyyr	1894	16	with	with	IN
cord-006860-a3b8hyyr	1894	17	euglobulin	euglobulin	NNP
cord-006860-a3b8hyyr	1894	18	precipitation	precipitation	NN
cord-006860-a3b8hyyr	1894	19	.	.	.
cord-006860-a3b8hyyr	1895	1	Total	total	JJ
cord-006860-a3b8hyyr	1895	2	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1895	3	activity	activity	NN
cord-006860-a3b8hyyr	1895	4	was	be	VBD
cord-006860-a3b8hyyr	1895	5	measured	measure	VBN
cord-006860-a3b8hyyr	1895	6	by	by	IN
cord-006860-a3b8hyyr	1895	7	the	the	DT
cord-006860-a3b8hyyr	1895	8	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1895	9	plate	plate	NN
cord-006860-a3b8hyyr	1895	10	method	method	NN
cord-006860-a3b8hyyr	1895	11	.	.	.
cord-006860-a3b8hyyr	1896	1	GBPg	GBPg	NNP
cord-006860-a3b8hyyr	1896	2	-	-	HYPH
cord-006860-a3b8hyyr	1896	3	SK	SK	NNP
cord-006860-a3b8hyyr	1896	4	possessed	possess	VBD
cord-006860-a3b8hyyr	1896	5	the	the	DT
cord-006860-a3b8hyyr	1896	6	greatest	great	JJS
cord-006860-a3b8hyyr	1896	7	stability	stability	NN
cord-006860-a3b8hyyr	1896	8	in	in	IN
cord-006860-a3b8hyyr	1896	9	human	human	JJ
cord-006860-a3b8hyyr	1896	10	plasma	plasma	NN
cord-006860-a3b8hyyr	1896	11	than	than	IN
cord-006860-a3b8hyyr	1896	12	APSAC	APSAC	NNP
cord-006860-a3b8hyyr	1896	13	or	or	CC
cord-006860-a3b8hyyr	1896	14	SK	SK	NNP
cord-006860-a3b8hyyr	1896	15	because	because	IN
cord-006860-a3b8hyyr	1896	16	of	of	IN
cord-006860-a3b8hyyr	1896	17	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1896	18	prolonged	prolong	VBN
cord-006860-a3b8hyyr	1896	19	inactivation	inactivation	NN
cord-006860-a3b8hyyr	1896	20	period	period	NN
cord-006860-a3b8hyyr	1896	21	(	(	-LRB-
cord-006860-a3b8hyyr	1896	22	the	the	DT
cord-006860-a3b8hyyr	1896	23	deacylation	deacylation	NN
cord-006860-a3b8hyyr	1896	24	half	half	JJ
cord-006860-a3b8hyyr	1896	25	-	-	HYPH
cord-006860-a3b8hyyr	1896	26	life	life	NN
cord-006860-a3b8hyyr	1896	27	for	for	IN
cord-006860-a3b8hyyr	1896	28	GBPg	GBPg	NNP
cord-006860-a3b8hyyr	1896	29	-	-	HYPH
cord-006860-a3b8hyyr	1896	30	SK	SK	NNP
cord-006860-a3b8hyyr	1896	31	was	be	VBD
cord-006860-a3b8hyyr	1896	32	230	230	CD
cord-006860-a3b8hyyr	1896	33	:	:	SYM
cord-006860-a3b8hyyr	1896	34	E	E	NNS
cord-006860-a3b8hyyr	1896	35	21	21	CD
cord-006860-a3b8hyyr	1896	36	rain	rain	NN
cord-006860-a3b8hyyr	1896	37	in	in	IN
cord-006860-a3b8hyyr	1896	38	contrast	contrast	NN
cord-006860-a3b8hyyr	1896	39	with	with	IN
cord-006860-a3b8hyyr	1896	40	73	73	CD
cord-006860-a3b8hyyr	1896	41	-~	-~	SYM
cord-006860-a3b8hyyr	1896	42	6	6	CD
cord-006860-a3b8hyyr	1896	43	min	min	NN
cord-006860-a3b8hyyr	1896	44	for	for	IN
cord-006860-a3b8hyyr	1896	45	APSAC	APSAC	NNP
cord-006860-a3b8hyyr	1896	46	)	)	-RRB-
cord-006860-a3b8hyyr	1896	47	.	.	.
cord-006860-a3b8hyyr	1897	1	The	the	DT
cord-006860-a3b8hyyr	1897	2	stability	stability	NN
cord-006860-a3b8hyyr	1897	3	degree	degree	NN
cord-006860-a3b8hyyr	1897	4	of	of	IN
cord-006860-a3b8hyyr	1897	5	two	two	CD
cord-006860-a3b8hyyr	1897	6	acylated	acylated	JJ
cord-006860-a3b8hyyr	1897	7	thrombolytics	thrombolytic	NNS
cord-006860-a3b8hyyr	1897	8	(	(	-LRB-
cord-006860-a3b8hyyr	1897	9	GBPg	GBPg	NNP
cord-006860-a3b8hyyr	1897	10	-	-	HYPH
cord-006860-a3b8hyyr	1897	11	SK	SK	NNP
cord-006860-a3b8hyyr	1897	12	and	and	CC
cord-006860-a3b8hyyr	1897	13	APSAC	APSAC	NNP
cord-006860-a3b8hyyr	1897	14	)	)	-RRB-
cord-006860-a3b8hyyr	1897	15	was	be	VBD
cord-006860-a3b8hyyr	1897	16	in	in	IN
cord-006860-a3b8hyyr	1897	17	order	order	NN
cord-006860-a3b8hyyr	1897	18	to	to	TO
cord-006860-a3b8hyyr	1897	19	inverse	inverse	VB
cord-006860-a3b8hyyr	1897	20	proportion	proportion	NN
cord-006860-a3b8hyyr	1897	21	of	of	IN
cord-006860-a3b8hyyr	1897	22	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1897	23	first	first	JJ
cord-006860-a3b8hyyr	1897	24	order	order	NN
cord-006860-a3b8hyyr	1897	25	rate	rate	NN
cord-006860-a3b8hyyr	1897	26	deacylation	deacylation	NN
cord-006860-a3b8hyyr	1897	27	constants	constant	NNS
cord-006860-a3b8hyyr	1897	28	(	(	-LRB-
cord-006860-a3b8hyyr	1897	29	2.9	2.9	CD
cord-006860-a3b8hyyr	1897	30	•	•	NNS
cord-006860-a3b8hyyr	1897	31	10	10	CD
cord-006860-a3b8hyyr	1897	32	-4	-4	NNS
cord-006860-a3b8hyyr	1897	33	and	and	CC
cord-006860-a3b8hyyr	1897	34	6.0	6.0	CD
cord-006860-a3b8hyyr	1897	35	•	•	NNS
cord-006860-a3b8hyyr	1897	36	10-s	10-s	CD
cord-006860-a3b8hyyr	1897	37	sec-1	sec-1	NN
cord-006860-a3b8hyyr	1897	38	respectively	respectively	RB
cord-006860-a3b8hyyr	1897	39	)	)	-RRB-
cord-006860-a3b8hyyr	1897	40	.	.	.
cord-006860-a3b8hyyr	1898	1	The	the	DT
cord-006860-a3b8hyyr	1898	2	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1898	3	potency	potency	NN
cord-006860-a3b8hyyr	1898	4	of	of	IN
cord-006860-a3b8hyyr	1898	5	SK	SK	NNP
cord-006860-a3b8hyyr	1898	6	,	,	,
cord-006860-a3b8hyyr	1898	7	APSAC	APSAC	NNP
cord-006860-a3b8hyyr	1898	8	and	and	CC
cord-006860-a3b8hyyr	1898	9	GBPg	GBPg	NNP
cord-006860-a3b8hyyr	1898	10	-	-	HYPH
cord-006860-a3b8hyyr	1898	11	SK	SK	NNP
cord-006860-a3b8hyyr	1898	12	was	be	VBD
cord-006860-a3b8hyyr	1898	13	measured	measure	VBN
cord-006860-a3b8hyyr	1898	14	by	by	IN
cord-006860-a3b8hyyr	1898	15	1251-labeled	1251-labeled	CD
cord-006860-a3b8hyyr	1898	16	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1898	17	clot	clot	NN
cord-006860-a3b8hyyr	1898	18	lysis	lysis	NN
cord-006860-a3b8hyyr	1898	19	in	in	IN
cord-006860-a3b8hyyr	1898	20	plasma	plasma	NN
cord-006860-a3b8hyyr	1898	21	and	and	CC
cord-006860-a3b8hyyr	1898	22	in	in	IN
cord-006860-a3b8hyyr	1898	23	vivo	vivo	NN
cord-006860-a3b8hyyr	1898	24	by	by	IN
cord-006860-a3b8hyyr	1898	25	lysis	lysis	NN
cord-006860-a3b8hyyr	1898	26	of	of	IN
cord-006860-a3b8hyyr	1898	27	the	the	DT
cord-006860-a3b8hyyr	1898	28	preliminary	preliminary	NN
cord-006860-a3b8hyyr	1898	29	formed	form	VBN
cord-006860-a3b8hyyr	1898	30	1251-labeled	1251-labeled	CD
cord-006860-a3b8hyyr	1898	31	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1898	32	clot	clot	NN
cord-006860-a3b8hyyr	1898	33	inserted	insert	VBN
cord-006860-a3b8hyyr	1898	34	into	into	IN
cord-006860-a3b8hyyr	1898	35	the	the	DT
cord-006860-a3b8hyyr	1898	36	jugular	jugular	NN
cord-006860-a3b8hyyr	1898	37	vein	vein	NN
cord-006860-a3b8hyyr	1898	38	.	.	.
cord-006860-a3b8hyyr	1899	1	FibrinolytJc	fibrinolytjc	NN
cord-006860-a3b8hyyr	1899	2	activity	activity	NN
cord-006860-a3b8hyyr	1899	3	of	of	IN
cord-006860-a3b8hyyr	1899	4	acylated	acylated	JJ
cord-006860-a3b8hyyr	1899	5	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	1899	6	activators	activator	NNS
cord-006860-a3b8hyyr	1899	7	gradually	gradually	RB
cord-006860-a3b8hyyr	1899	8	increased	increase	VBD
cord-006860-a3b8hyyr	1899	9	in	in	IN
cord-006860-a3b8hyyr	1899	10	time	time	NN
cord-006860-a3b8hyyr	1899	11	.	.	.
cord-006860-a3b8hyyr	1900	1	Under	under	IN
cord-006860-a3b8hyyr	1900	2	SK	SK	NNP
cord-006860-a3b8hyyr	1900	3	administration	administration	NN
cord-006860-a3b8hyyr	1900	4	,	,	,
cord-006860-a3b8hyyr	1900	5	the	the	DT
cord-006860-a3b8hyyr	1900	6	clot	clot	NN
cord-006860-a3b8hyyr	1900	7	lysis	lysis	NN
cord-006860-a3b8hyyr	1900	8	came	come	VBD
cord-006860-a3b8hyyr	1900	9	to	to	IN
cord-006860-a3b8hyyr	1900	10	the	the	DT
cord-006860-a3b8hyyr	1900	11	end	end	NN
cord-006860-a3b8hyyr	1900	12	by	by	IN
cord-006860-a3b8hyyr	1900	13	2	2	CD
cord-006860-a3b8hyyr	1900	14	hours	hour	NNS
cord-006860-a3b8hyyr	1900	15	while	while	IN
cord-006860-a3b8hyyr	1900	16	APSAC	APSAC	NNP
cord-006860-a3b8hyyr	1900	17	and	and	CC
cord-006860-a3b8hyyr	1900	18	GBPg	GBPg	NNP
cord-006860-a3b8hyyr	1900	19	-	-	HYPH
cord-006860-a3b8hyyr	1900	20	SK	SK	NNP
cord-006860-a3b8hyyr	1900	21	have	have	VBP
cord-006860-a3b8hyyr	1900	22	n't	not	RB
cord-006860-a3b8hyyr	1900	23	lost	lose	VBN
cord-006860-a3b8hyyr	1900	24	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1900	25	activity	activity	NN
cord-006860-a3b8hyyr	1900	26	for	for	IN
cord-006860-a3b8hyyr	1900	27	5	5	CD
cord-006860-a3b8hyyr	1900	28	-6	-6	CD
cord-006860-a3b8hyyr	1900	29	hours	hour	NNS
cord-006860-a3b8hyyr	1900	30	.	.	.
cord-006860-a3b8hyyr	1901	1	GBPg	GBPg	NNP
cord-006860-a3b8hyyr	1901	2	-	-	HYPH
cord-006860-a3b8hyyr	1901	3	SK	SK	NNP
cord-006860-a3b8hyyr	1901	4	possessed	possess	VBD
cord-006860-a3b8hyyr	1901	5	significantly	significantly	RB
cord-006860-a3b8hyyr	1901	6	more	more	RBR
cord-006860-a3b8hyyr	1901	7	prolonged	prolong	VBN
cord-006860-a3b8hyyr	1901	8	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1901	9	activity	activity	NN
cord-006860-a3b8hyyr	1901	10	than	than	IN
cord-006860-a3b8hyyr	1901	11	APSAC	APSAC	NNP
cord-006860-a3b8hyyr	1901	12	,	,	,
cord-006860-a3b8hyyr	1901	13	The	the	DT
cord-006860-a3b8hyyr	1901	14	acyl	acyl	NN
cord-006860-a3b8hyyr	1901	15	-	-	HYPH
cord-006860-a3b8hyyr	1901	16	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	1901	17	did	do	VBD
cord-006860-a3b8hyyr	1901	18	not	not	RB
cord-006860-a3b8hyyr	1901	19	significantly	significantly	RB
cord-006860-a3b8hyyr	1901	20	influence	influence	VB
cord-006860-a3b8hyyr	1901	21	on	on	IN
cord-006860-a3b8hyyr	1901	22	plasminogen,,.~2-anfiplasmin	plasminogen,,.~2-anfiplasmin	CD
cord-006860-a3b8hyyr	1901	23	and	and	CC
cord-006860-a3b8hyyr	1901	24	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	1901	25	levels	level	NNS
cord-006860-a3b8hyyr	1901	26	in	in	IN
cord-006860-a3b8hyyr	1901	27	plasma	plasma	NN
cord-006860-a3b8hyyr	1901	28	according	accord	VBG
cord-006860-a3b8hyyr	1901	29	to	to	IN
cord-006860-a3b8hyyr	1901	30	their	-PRON-	PRP$
cord-006860-a3b8hyyr	1901	31	activity	activity	NN
cord-006860-a3b8hyyr	1901	32	specific	specific	JJ
cord-006860-a3b8hyyr	1901	33	to	to	IN
cord-006860-a3b8hyyr	1901	34	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1901	35	-	-	HYPH
cord-006860-a3b8hyyr	1901	36	bound	bind	VBN
cord-006860-a3b8hyyr	1901	37	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	1901	38	.	.	.
cord-006860-a3b8hyyr	1902	1	In	in	IN
cord-006860-a3b8hyyr	1902	2	opposite	opposite	JJ
cord-006860-a3b8hyyr	1902	3	,	,	,
cord-006860-a3b8hyyr	1902	4	SK	SK	NNP
cord-006860-a3b8hyyr	1902	5	produced	produce	VBD
cord-006860-a3b8hyyr	1902	6	a	a	DT
cord-006860-a3b8hyyr	1902	7	significant	significant	JJ
cord-006860-a3b8hyyr	1902	8	depletion	depletion	NN
cord-006860-a3b8hyyr	1902	9	of	of	IN
cord-006860-a3b8hyyr	1902	10	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	1902	11	,	,	,
cord-006860-a3b8hyyr	1902	12	~-2antiplasmin	~-2antiplasmin	NNP
cord-006860-a3b8hyyr	1902	13	and	and	CC
cord-006860-a3b8hyyr	1902	14	fibdnogen	fibdnogen	NNP
cord-006860-a3b8hyyr	1902	15	levels	level	NNS
cord-006860-a3b8hyyr	1902	16	in	in	IN
cord-006860-a3b8hyyr	1902	17	plasma	plasma	NN
cord-006860-a3b8hyyr	1902	18	.	.	.
cord-006860-a3b8hyyr	1903	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1903	2	seems	seem	VBZ
cord-006860-a3b8hyyr	1903	3	,	,	,
cord-006860-a3b8hyyr	1903	4	on	on	IN
cord-006860-a3b8hyyr	1903	5	the	the	DT
cord-006860-a3b8hyyr	1903	6	basis	basis	NN
cord-006860-a3b8hyyr	1903	7	on	on	IN
cord-006860-a3b8hyyr	1903	8	in	in	IN
cord-006860-a3b8hyyr	1903	9	vitro	vitro	FW
cord-006860-a3b8hyyr	1903	10	and	and	CC
cord-006860-a3b8hyyr	1903	11	an	an	DT
cord-006860-a3b8hyyr	1903	12	animal	animal	NN
cord-006860-a3b8hyyr	1903	13	experimentation	experimentation	NN
cord-006860-a3b8hyyr	1903	14	,	,	,
cord-006860-a3b8hyyr	1903	15	than	than	IN
cord-006860-a3b8hyyr	1903	16	APSAC	APSAC	NNP
cord-006860-a3b8hyyr	1903	17	with	with	IN
cord-006860-a3b8hyyr	1903	18	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1903	19	moderately	moderately	RB
cord-006860-a3b8hyyr	1903	20	fast	fast	JJ
cord-006860-a3b8hyyr	1903	21	deacylation	deacylation	NN
cord-006860-a3b8hyyr	1903	22	rate	rate	NN
cord-006860-a3b8hyyr	1903	23	is	be	VBZ
cord-006860-a3b8hyyr	1903	24	more	more	RBR
cord-006860-a3b8hyyr	1903	25	suitable	suitable	JJ
cord-006860-a3b8hyyr	1903	26	for	for	IN
cord-006860-a3b8hyyr	1903	27	rapid	rapid	JJ
cord-006860-a3b8hyyr	1903	28	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	1903	29	effect	effect	NN
cord-006860-a3b8hyyr	1903	30	,	,	,
cord-006860-a3b8hyyr	1903	31	but	but	CC
cord-006860-a3b8hyyr	1903	32	GBPg	GBPg	NNP
cord-006860-a3b8hyyr	1903	33	-	-	HYPH
cord-006860-a3b8hyyr	1903	34	SK	SK	NNP
cord-006860-a3b8hyyr	1903	35	with	with	IN
cord-006860-a3b8hyyr	1903	36	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1903	37	slow	slow	JJ
cord-006860-a3b8hyyr	1903	38	deacylation	deacylation	NN
cord-006860-a3b8hyyr	1903	39	rate	rate	NN
cord-006860-a3b8hyyr	1903	40	is	be	VBZ
cord-006860-a3b8hyyr	1903	41	suitable	suitable	JJ
cord-006860-a3b8hyyr	1903	42	for	for	IN
cord-006860-a3b8hyyr	1903	43	deep	deep	JJ
cord-006860-a3b8hyyr	1903	44	vein	vein	NN
cord-006860-a3b8hyyr	1903	45	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	1903	46	,	,	,
cord-006860-a3b8hyyr	1903	47	when	when	WRB
cord-006860-a3b8hyyr	1903	48	the	the	DT
cord-006860-a3b8hyyr	1903	49	rapid	rapid	JJ
cord-006860-a3b8hyyr	1903	50	thrombolysis	thrombolysis	NN
cord-006860-a3b8hyyr	1903	51	is	be	VBZ
cord-006860-a3b8hyyr	1903	52	less	less	RBR
cord-006860-a3b8hyyr	1903	53	critical	critical	JJ
cord-006860-a3b8hyyr	1903	54	.	.	.
cord-006860-a3b8hyyr	1904	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1904	2	's	be	VBZ
cord-006860-a3b8hyyr	1904	3	well	well	RB
cord-006860-a3b8hyyr	1904	4	known	know	VBN
cord-006860-a3b8hyyr	1904	5	that	that	IN
cord-006860-a3b8hyyr	1904	6	the	the	DT
cord-006860-a3b8hyyr	1904	7	complete	complete	JJ
cord-006860-a3b8hyyr	1904	8	lysis	lysis	NN
cord-006860-a3b8hyyr	1904	9	of	of	IN
cord-006860-a3b8hyyr	1904	10	thrombi	thrombi	NNP
cord-006860-a3b8hyyr	1904	11	usually	usually	RB
cord-006860-a3b8hyyr	1904	12	is	be	VBZ
cord-006860-a3b8hyyr	1904	13	n't	not	RB
cord-006860-a3b8hyyr	1904	14	observed	observe	VBN
cord-006860-a3b8hyyr	1904	15	at	at	IN
cord-006860-a3b8hyyr	1904	16	the	the	DT
cord-006860-a3b8hyyr	1904	17	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	1904	18	therapy	therapy	NN
cord-006860-a3b8hyyr	1904	19	.	.	.
cord-006860-a3b8hyyr	1905	1	At	at	IN
cord-006860-a3b8hyyr	1905	2	present	present	JJ
cord-006860-a3b8hyyr	1905	3	study	study	NN
cord-006860-a3b8hyyr	1905	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	1905	5	have	have	VBP
cord-006860-a3b8hyyr	1905	6	attempted	attempt	VBN
cord-006860-a3b8hyyr	1905	7	to	to	TO
cord-006860-a3b8hyyr	1905	8	quantify	quantify	VB
cord-006860-a3b8hyyr	1905	9	the	the	DT
cord-006860-a3b8hyyr	1905	10	possible	possible	JJ
cord-006860-a3b8hyyr	1905	11	mechanism	mechanism	NN
cord-006860-a3b8hyyr	1905	12	of	of	IN
cord-006860-a3b8hyyr	1905	13	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1905	14	inhibition	inhibition	NN
cord-006860-a3b8hyyr	1905	15	during	during	IN
cord-006860-a3b8hyyr	1905	16	the	the	DT
cord-006860-a3b8hyyr	1905	17	thrombolysis	thrombolysis	NN
cord-006860-a3b8hyyr	1905	18	.	.	.
cord-006860-a3b8hyyr	1906	1	125I	125i	LS
cord-006860-a3b8hyyr	1907	1	-Labelled	-labelle	VBN
cord-006860-a3b8hyyr	1907	2	partially	partially	RB
cord-006860-a3b8hyyr	1907	3	cross	cross	JJ
cord-006860-a3b8hyyr	1907	4	-	-	JJ
cord-006860-a3b8hyyr	1907	5	linked	link	VBN
cord-006860-a3b8hyyr	1907	6	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1907	7	clots	clot	NNS
cord-006860-a3b8hyyr	1907	8	of	of	IN
cord-006860-a3b8hyyr	1907	9	different	different	JJ
cord-006860-a3b8hyyr	1907	10	volume	volume	NN
cord-006860-a3b8hyyr	1907	11	(	(	-LRB-
cord-006860-a3b8hyyr	1907	12	0.1	0.1	CD
cord-006860-a3b8hyyr	1907	13	-	-	SYM
cord-006860-a3b8hyyr	1907	14	0.35	0.35	CD
cord-006860-a3b8hyyr	1907	15	ml	ml	NNS
cord-006860-a3b8hyyr	1907	16	)	)	-RRB-
cord-006860-a3b8hyyr	1907	17	were	be	VBD
cord-006860-a3b8hyyr	1907	18	immersed	immerse	VBN
cord-006860-a3b8hyyr	1907	19	in	in	IN
cord-006860-a3b8hyyr	1907	20	Tris	Tris	NNP
cord-006860-a3b8hyyr	1907	21	-	-	HYPH
cord-006860-a3b8hyyr	1907	22	HCl	HCl	NNP
cord-006860-a3b8hyyr	1907	23	buffer	buffer	NN
cord-006860-a3b8hyyr	1907	24	(	(	-LRB-
cord-006860-a3b8hyyr	1907	25	3	3	CD
cord-006860-a3b8hyyr	1907	26	ml	ml	NN
cord-006860-a3b8hyyr	1907	27	)	)	-RRB-
cord-006860-a3b8hyyr	1907	28	containing	contain	VBG
cord-006860-a3b8hyyr	1907	29	plasmin	plasmin	NNP
cord-006860-a3b8hyyr	1907	30	(	(	-LRB-
cord-006860-a3b8hyyr	1907	31	5	5	CD
cord-006860-a3b8hyyr	1907	32	-	-	SYM
cord-006860-a3b8hyyr	1907	33	100	100	CD
cord-006860-a3b8hyyr	1907	34	nM	nM	NNP
cord-006860-a3b8hyyr	1907	35	)	)	-RRB-
cord-006860-a3b8hyyr	1907	36	at	at	IN
cord-006860-a3b8hyyr	1907	37	37	37	CD
cord-006860-a3b8hyyr	1907	38	°	°	NN
cord-006860-a3b8hyyr	1907	39	C	c	NN
cord-006860-a3b8hyyr	1907	40	.	.	.
cord-006860-a3b8hyyr	1908	1	The	the	DT
cord-006860-a3b8hyyr	1908	2	lysis	lysis	NN
cord-006860-a3b8hyyr	1908	3	rate	rate	NN
cord-006860-a3b8hyyr	1908	4	was	be	VBD
cord-006860-a3b8hyyr	1908	5	detected	detect	VBN
cord-006860-a3b8hyyr	1908	6	by	by	IN
cord-006860-a3b8hyyr	1908	7	counting	count	VBG
cord-006860-a3b8hyyr	1908	8	of	of	IN
cord-006860-a3b8hyyr	1908	9	soluble	soluble	JJ
cord-006860-a3b8hyyr	1908	10	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1908	11	degradation	degradation	NN
cord-006860-a3b8hyyr	1908	12	products	product	NNS
cord-006860-a3b8hyyr	1908	13	(	(	-LRB-
cord-006860-a3b8hyyr	1908	14	FDP	FDP	NNP
cord-006860-a3b8hyyr	1908	15	)	)	-RRB-
cord-006860-a3b8hyyr	1908	16	.	.	.
cord-006860-a3b8hyyr	1909	1	At	at	IN
cord-006860-a3b8hyyr	1909	2	all	all	PDT
cord-006860-a3b8hyyr	1909	3	the	the	DT
cord-006860-a3b8hyyr	1909	4	eases	ease	VBZ
cord-006860-a3b8hyyr	1909	5	lysis	lysis	NN
cord-006860-a3b8hyyr	1909	6	slowed	slow	VBD
cord-006860-a3b8hyyr	1909	7	down	down	RP
cord-006860-a3b8hyyr	1909	8	and	and	CC
cord-006860-a3b8hyyr	1909	9	stopped	stop	VBD
cord-006860-a3b8hyyr	1909	10	in	in	IN
cord-006860-a3b8hyyr	1909	11	3	3	CD
cord-006860-a3b8hyyr	1909	12	hs	hs	NNP
cord-006860-a3b8hyyr	1909	13	though	though	IN
cord-006860-a3b8hyyr	1909	14	clots	clot	NNS
cord-006860-a3b8hyyr	1909	15	dissolved	dissolve	VBD
cord-006860-a3b8hyyr	1909	16	up	up	RP
cord-006860-a3b8hyyr	1909	17	to	to	IN
cord-006860-a3b8hyyr	1909	18	only	only	RB
cord-006860-a3b8hyyr	1909	19	60	60	CD
cord-006860-a3b8hyyr	1909	20	-	-	SYM
cord-006860-a3b8hyyr	1909	21	85	85	CD
cord-006860-a3b8hyyr	1909	22	%	%	NN
cord-006860-a3b8hyyr	1909	23	.	.	.
cord-006860-a3b8hyyr	1910	1	No	no	DT
cord-006860-a3b8hyyr	1910	2	irreversible	irreversible	JJ
cord-006860-a3b8hyyr	1910	3	inlaibition	inlaibition	NN
cord-006860-a3b8hyyr	1910	4	of	of	IN
cord-006860-a3b8hyyr	1910	5	plasmin	plasmin	NN
cord-006860-a3b8hyyr	1910	6	caused	cause	VBN
cord-006860-a3b8hyyr	1910	7	by	by	IN
cord-006860-a3b8hyyr	1910	8	denaturation	denaturation	NN
cord-006860-a3b8hyyr	1910	9	occur	occur	VBP
cord-006860-a3b8hyyr	1910	10	as	as	IN
cord-006860-a3b8hyyr	1910	11	was	be	VBD
cord-006860-a3b8hyyr	1910	12	judged	judge	VBN
cord-006860-a3b8hyyr	1910	13	by	by	IN
cord-006860-a3b8hyyr	1910	14	the	the	DT
cord-006860-a3b8hyyr	1910	15	measurement	measurement	NN
cord-006860-a3b8hyyr	1910	16	of	of	IN
cord-006860-a3b8hyyr	1910	17	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1910	18	activity	activity	NN
cord-006860-a3b8hyyr	1910	19	at	at	IN
cord-006860-a3b8hyyr	1910	20	the	the	DT
cord-006860-a3b8hyyr	1910	21	diluted	dilute	VBN
cord-006860-a3b8hyyr	1910	22	samples	sample	NNS
cord-006860-a3b8hyyr	1910	23	.	.	.
cord-006860-a3b8hyyr	1911	1	However	however	RB
cord-006860-a3b8hyyr	1911	2	the	the	DT
cord-006860-a3b8hyyr	1911	3	increase	increase	NN
cord-006860-a3b8hyyr	1911	4	of	of	IN
cord-006860-a3b8hyyr	1911	5	FDP	FDP	NNP
cord-006860-a3b8hyyr	1911	6	concentration	concentration	NN
cord-006860-a3b8hyyr	1911	7	in	in	IN
cord-006860-a3b8hyyr	1911	8	surrounding	surround	VBG
cord-006860-a3b8hyyr	1911	9	buffer	buffer	NN
cord-006860-a3b8hyyr	1911	10	led	lead	VBD
cord-006860-a3b8hyyr	1911	11	to	to	IN
cord-006860-a3b8hyyr	1911	12	the	the	DT
cord-006860-a3b8hyyr	1911	13	reversible	reversible	JJ
cord-006860-a3b8hyyr	1911	14	inhibition	inhibition	NN
cord-006860-a3b8hyyr	1911	15	of	of	IN
cord-006860-a3b8hyyr	1911	16	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1911	17	activity	activity	NN
cord-006860-a3b8hyyr	1911	18	of	of	IN
cord-006860-a3b8hyyr	1911	19	plasmin	plasmin	NN
cord-006860-a3b8hyyr	1911	20	up	up	IN
cord-006860-a3b8hyyr	1911	21	to	to	TO
cord-006860-a3b8hyyr	1911	22	5	5	CD
cord-006860-a3b8hyyr	1911	23	%	%	NN
cord-006860-a3b8hyyr	1911	24	of	of	IN
cord-006860-a3b8hyyr	1911	25	baseline	baseline	NN
cord-006860-a3b8hyyr	1911	26	.	.	.
cord-006860-a3b8hyyr	1912	1	The	the	DT
cord-006860-a3b8hyyr	1912	2	SDS	SDS	NNP
cord-006860-a3b8hyyr	1912	3	-	-	HYPH
cord-006860-a3b8hyyr	1912	4	PAGE	PAGE	NNP
cord-006860-a3b8hyyr	1912	5	analysis	analysis	NN
cord-006860-a3b8hyyr	1912	6	under	under	IN
cord-006860-a3b8hyyr	1912	7	non	non	JJ
cord-006860-a3b8hyyr	1912	8	-	-	JJ
cord-006860-a3b8hyyr	1912	9	reduced	reduced	JJ
cord-006860-a3b8hyyr	1912	10	conditions	condition	NNS
cord-006860-a3b8hyyr	1912	11	shown	show	VBN
cord-006860-a3b8hyyr	1912	12	the	the	DT
cord-006860-a3b8hyyr	1912	13	acoumulation	acoumulation	NN
cord-006860-a3b8hyyr	1912	14	of	of	IN
cord-006860-a3b8hyyr	1912	15	high	high	JJ
cord-006860-a3b8hyyr	1912	16	-	-	HYPH
cord-006860-a3b8hyyr	1912	17	molecular	molecular	JJ
cord-006860-a3b8hyyr	1912	18	weight	weight	NN
cord-006860-a3b8hyyr	1912	19	FDP	FDP	NNP
cord-006860-a3b8hyyr	1912	20	at	at	IN
cord-006860-a3b8hyyr	1912	21	the	the	DT
cord-006860-a3b8hyyr	1912	22	surrounding	surround	VBG
cord-006860-a3b8hyyr	1912	23	buffer	buffer	NN
cord-006860-a3b8hyyr	1912	24	.	.	.
cord-006860-a3b8hyyr	1913	1	The	the	DT
cord-006860-a3b8hyyr	1913	2	inhibition	inhibition	NN
cord-006860-a3b8hyyr	1913	3	phenomenon	phenomenon	NN
cord-006860-a3b8hyyr	1913	4	could	could	MD
cord-006860-a3b8hyyr	1913	5	be	be	VB
cord-006860-a3b8hyyr	1913	6	connected	connect	VBN
cord-006860-a3b8hyyr	1913	7	with	with	IN
cord-006860-a3b8hyyr	1913	8	the	the	DT
cord-006860-a3b8hyyr	1913	9	specific	specific	JJ
cord-006860-a3b8hyyr	1913	10	binding	binding	NN
cord-006860-a3b8hyyr	1913	11	of	of	IN
cord-006860-a3b8hyyr	1913	12	plasrnin	plasrnin	NN
cord-006860-a3b8hyyr	1913	13	with	with	IN
cord-006860-a3b8hyyr	1913	14	soluble	soluble	JJ
cord-006860-a3b8hyyr	1913	15	FDP	FDP	NNP
cord-006860-a3b8hyyr	1913	16	having	have	VBG
cord-006860-a3b8hyyr	1913	17	exposed	expose	VBN
cord-006860-a3b8hyyr	1913	18	lysine	lysine	NN
cord-006860-a3b8hyyr	1913	19	residues	residue	NNS
cord-006860-a3b8hyyr	1913	20	and	and	CC
cord-006860-a3b8hyyr	1913	21	the	the	DT
cord-006860-a3b8hyyr	1913	22	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	1913	23	removal	removal	NN
cord-006860-a3b8hyyr	1913	24	of	of	IN
cord-006860-a3b8hyyr	1913	25	enzyme	enzyme	NN
cord-006860-a3b8hyyr	1913	26	from	from	IN
cord-006860-a3b8hyyr	1913	27	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1913	28	surface	surface	NN
cord-006860-a3b8hyyr	1913	29	.	.	.
cord-006860-a3b8hyyr	1914	1	Unexpectedly	unexpectedly	RB
cord-006860-a3b8hyyr	1914	2	since	since	IN
cord-006860-a3b8hyyr	1914	3	the	the	DT
cord-006860-a3b8hyyr	1914	4	heterogeneous	heterogeneous	JJ
cord-006860-a3b8hyyr	1914	5	character	character	NN
cord-006860-a3b8hyyr	1914	6	of	of	IN
cord-006860-a3b8hyyr	1914	7	occurred	occur	VBN
cord-006860-a3b8hyyr	1914	8	reactions	reaction	NNS
cord-006860-a3b8hyyr	1914	9	tile	tile	NN
cord-006860-a3b8hyyr	1914	10	change	change	NN
cord-006860-a3b8hyyr	1914	11	of	of	IN
cord-006860-a3b8hyyr	1914	12	the	the	DT
cord-006860-a3b8hyyr	1914	13	clots	clot	NNS
cord-006860-a3b8hyyr	1914	14	surface	surface	NN
cord-006860-a3b8hyyr	1914	15	area	area	NN
cord-006860-a3b8hyyr	1914	16	during	during	IN
cord-006860-a3b8hyyr	1914	17	lysis	lysis	NN
cord-006860-a3b8hyyr	1914	18	did	do	VBD
cord-006860-a3b8hyyr	1914	19	n't	not	RB
cord-006860-a3b8hyyr	1914	20	affect	affect	VB
cord-006860-a3b8hyyr	1914	21	the	the	DT
cord-006860-a3b8hyyr	1914	22	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1914	23	kinetics	kinetics	NNP
cord-006860-a3b8hyyr	1914	24	in	in	IN
cord-006860-a3b8hyyr	1914	25	all	all	PDT
cord-006860-a3b8hyyr	1914	26	the	the	DT
cord-006860-a3b8hyyr	1914	27	concentration	concentration	NN
cord-006860-a3b8hyyr	1914	28	intervals	interval	NNS
cord-006860-a3b8hyyr	1914	29	.	.	.
cord-006860-a3b8hyyr	1915	1	To	to	TO
cord-006860-a3b8hyyr	1915	2	estimate	estimate	VB
cord-006860-a3b8hyyr	1915	3	the	the	DT
cord-006860-a3b8hyyr	1915	4	kinetic	kinetic	JJ
cord-006860-a3b8hyyr	1915	5	parameters	parameter	NNS
cord-006860-a3b8hyyr	1915	6	the	the	DT
cord-006860-a3b8hyyr	1915	7	kinetic	kinetic	JJ
cord-006860-a3b8hyyr	1915	8	curves	curve	NNS
cord-006860-a3b8hyyr	1915	9	were	be	VBD
cord-006860-a3b8hyyr	1915	10	linear	linear	JJ
cord-006860-a3b8hyyr	1915	11	in	in	IN
cord-006860-a3b8hyyr	1915	12	the	the	DT
cord-006860-a3b8hyyr	1915	13	coordinates	coordinate	NNS
cord-006860-a3b8hyyr	1915	14	[	[	-LRB-
cord-006860-a3b8hyyr	1915	15	P1	P1	NNP
cord-006860-a3b8hyyr	1915	16	/	/	SYM
cord-006860-a3b8hyyr	1915	17	t	t	NNP
cord-006860-a3b8hyyr	1915	18	(	(	-LRB-
cord-006860-a3b8hyyr	1915	19	l	l	NNP
cord-006860-a3b8hyyr	1915	20	/	/	SYM
cord-006860-a3b8hyyr	1915	21	t*ln(ISl	t*ln(ISl	NNP
cord-006860-a3b8hyyr	1915	22	°	°	NNP
cord-006860-a3b8hyyr	1915	23	{(lSlo.lPi	{(lSlo.lPi	NNP
cord-006860-a3b8hyyr	1915	24	)	)	-RRB-
cord-006860-a3b8hyyr	1915	25	)	)	-RRB-
cord-006860-a3b8hyyr	1915	26	.	.	.
cord-006860-a3b8hyyr	1916	1	The	the	DT
cord-006860-a3b8hyyr	1916	2	obtained	obtain	VBN
cord-006860-a3b8hyyr	1916	3	parameters	parameter	NNS
cord-006860-a3b8hyyr	1916	4	were	be	VBD
cord-006860-a3b8hyyr	1916	5	following	follow	VBG
cord-006860-a3b8hyyr	1916	6	:	:	:
cord-006860-a3b8hyyr	1916	7	keat	keat	NNP
cord-006860-a3b8hyyr	1916	8	=	=	SYM
cord-006860-a3b8hyyr	1916	9	l.36	l.36	NNP
cord-006860-a3b8hyyr	1916	10	min	min	NNP
cord-006860-a3b8hyyr	1916	11	-	-	HYPH
cord-006860-a3b8hyyr	1916	12	l	l	NNP
cord-006860-a3b8hyyr	1916	13	,	,	,
cord-006860-a3b8hyyr	1916	14	KM	KM	NNP
cord-006860-a3b8hyyr	1916	15	=	=	SYM
cord-006860-a3b8hyyr	1916	16	l.33	l.33	NNP
cord-006860-a3b8hyyr	1916	17	ixM	ixM	NNP
cord-006860-a3b8hyyr	1916	18	,	,	,
cord-006860-a3b8hyyr	1916	19	Kp=0.12	kp=0.12	UH
cord-006860-a3b8hyyr	1916	20	~tM.	~tM.	.
cord-006860-a3b8hyyr	1917	1	The	the	DT
cord-006860-a3b8hyyr	1917	2	clinical	clinical	JJ
cord-006860-a3b8hyyr	1917	3	trials	trial	NNS
cord-006860-a3b8hyyr	1917	4	have	have	VBP
cord-006860-a3b8hyyr	1917	5	shown	show	VBN
cord-006860-a3b8hyyr	1917	6	that	that	IN
cord-006860-a3b8hyyr	1917	7	FDP	FDP	NNP
cord-006860-a3b8hyyr	1917	8	concentrations	concentration	NNS
cord-006860-a3b8hyyr	1917	9	at	at	IN
cord-006860-a3b8hyyr	1917	10	the	the	DT
cord-006860-a3b8hyyr	1917	11	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	1917	12	therapy	therapy	NN
cord-006860-a3b8hyyr	1917	13	of	of	IN
cord-006860-a3b8hyyr	1917	14	deep	deep	JJ
cord-006860-a3b8hyyr	1917	15	venous	venous	JJ
cord-006860-a3b8hyyr	1917	16	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	1917	17	and	and	CC
cord-006860-a3b8hyyr	1917	18	acute	acute	JJ
cord-006860-a3b8hyyr	1917	19	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	1917	20	infarction	infarction	NN
cord-006860-a3b8hyyr	1917	21	usually	usually	RB
cord-006860-a3b8hyyr	1917	22	was	be	VBD
cord-006860-a3b8hyyr	1917	23	approximately	approximately	RB
cord-006860-a3b8hyyr	1917	24	in	in	IN
cord-006860-a3b8hyyr	1917	25	the	the	DT
cord-006860-a3b8hyyr	1917	26	range	range	NN
cord-006860-a3b8hyyr	1917	27	0.05	0.05	CD
cord-006860-a3b8hyyr	1917	28	-	-	SYM
cord-006860-a3b8hyyr	1917	29	0.2	0.2	CD
cord-006860-a3b8hyyr	1917	30	~tM.	~tM.	.
cord-006860-a3b8hyyr	1918	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	1918	2	the	the	DT
cord-006860-a3b8hyyr	1918	3	described	describe	VBN
cord-006860-a3b8hyyr	1918	4	phenomenon	phenomenon	NN
cord-006860-a3b8hyyr	1918	5	of	of	IN
cord-006860-a3b8hyyr	1918	6	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1918	7	inhibition	inhibition	NN
cord-006860-a3b8hyyr	1918	8	by	by	IN
cord-006860-a3b8hyyr	1918	9	formed	form	VBN
cord-006860-a3b8hyyr	1918	10	FDP	FDP	NNP
cord-006860-a3b8hyyr	1918	11	may	may	MD
cord-006860-a3b8hyyr	1918	12	take	take	VB
cord-006860-a3b8hyyr	1918	13	place	place	NN
cord-006860-a3b8hyyr	1918	14	during	during	IN
cord-006860-a3b8hyyr	1918	15	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	1918	16	therapy	therapy	NN
cord-006860-a3b8hyyr	1918	17	.	.	.
cord-006860-a3b8hyyr	1919	1	Al	Al	NNP
cord-006860-a3b8hyyr	1919	2	.	.	.
cord-006860-a3b8hyyr	1920	1	Calatzis	Calatzis	NNP
cord-006860-a3b8hyyr	1920	2	,	,	,
cord-006860-a3b8hyyr	1920	3	An	An	NNP
cord-006860-a3b8hyyr	1920	4	.	.	.
cord-006860-a3b8hyyr	1921	1	Calatzis	Calatzis	NNP
cord-006860-a3b8hyyr	1921	2	,	,	,
cord-006860-a3b8hyyr	1921	3	+	+	CC
cord-006860-a3b8hyyr	1921	4	M.	M.	NNP
cord-006860-a3b8hyyr	1921	5	Klmg	Klmg	NNP
cord-006860-a3b8hyyr	1921	6	,	,	,
cord-006860-a3b8hyyr	1921	7	+	+	CC
cord-006860-a3b8hyyr	1921	8	L.	L.	NNP
cord-006860-a3b8hyyr	1921	9	Mielke	Mielke	NNP
cord-006860-a3b8hyyr	1921	10	,	,	,
cord-006860-a3b8hyyr	1921	11	+	+	CC
cord-006860-a3b8hyyr	1921	12	R.	R.	NNP
cord-006860-a3b8hyyr	1921	13	Hipp	Hipp	NNP
cord-006860-a3b8hyyr	1921	14	,	,	,
cord-006860-a3b8hyyr	1921	15	A.	A.	NNP
cord-006860-a3b8hyyr	1921	16	Stemberger	Stemberger	NNP
cord-006860-a3b8hyyr	1921	17	Institute	Institute	NNP
cord-006860-a3b8hyyr	1921	18	for	for	IN
cord-006860-a3b8hyyr	1921	19	Experimental	Experimental	NNP
cord-006860-a3b8hyyr	1921	20	Surgery	Surgery	NNP
cord-006860-a3b8hyyr	1921	21	and	and	CC
cord-006860-a3b8hyyr	1922	1	+	+	CC
cord-006860-a3b8hyyr	1922	2	Institute	Institute	NNP
cord-006860-a3b8hyyr	1922	3	of	of	IN
cord-006860-a3b8hyyr	1922	4	Anesthesiology	Anesthesiology	NNP
cord-006860-a3b8hyyr	1922	5	Technische	Technische	NNP
cord-006860-a3b8hyyr	1923	1	Universit~.t	Universit~.t	NNS
cord-006860-a3b8hyyr	1924	1	MOnchen	MOnchen	NNP
cord-006860-a3b8hyyr	1924	2	Thrombelastography	Thrombelastography	NNP
cord-006860-a3b8hyyr	1924	3	(	(	-LRB-
cord-006860-a3b8hyyr	1924	4	TEG	TEG	NNP
cord-006860-a3b8hyyr	1924	5	)	)	-RRB-
cord-006860-a3b8hyyr	1924	6	is	be	VBZ
cord-006860-a3b8hyyr	1924	7	an	an	DT
cord-006860-a3b8hyyr	1924	8	established	established	JJ
cord-006860-a3b8hyyr	1924	9	method	method	NN
cord-006860-a3b8hyyr	1924	10	for	for	IN
cord-006860-a3b8hyyr	1924	11	the	the	DT
cord-006860-a3b8hyyr	1924	12	detection	detection	NN
cord-006860-a3b8hyyr	1924	13	of	of	IN
cord-006860-a3b8hyyr	1924	14	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1924	15	.	.	.
cord-006860-a3b8hyyr	1925	1	Fibfinolysis	Fibfinolysis	NNP
cord-006860-a3b8hyyr	1925	2	is	be	VBZ
cord-006860-a3b8hyyr	1925	3	usually	usually	RB
cord-006860-a3b8hyyr	1925	4	determined	determine	VBN
cord-006860-a3b8hyyr	1925	5	when	when	WRB
cord-006860-a3b8hyyr	1925	6	the	the	DT
cord-006860-a3b8hyyr	1925	7	TEG	TEG	NNP
cord-006860-a3b8hyyr	1925	8	amplitude	amplitude	NN
cord-006860-a3b8hyyr	1925	9	decreases	decrease	VBZ
cord-006860-a3b8hyyr	1925	10	by	by	IN
cord-006860-a3b8hyyr	1925	11	more	more	JJR
cord-006860-a3b8hyyr	1925	12	than	than	IN
cord-006860-a3b8hyyr	1925	13	15	15	CD
cord-006860-a3b8hyyr	1925	14	%	%	NN
cord-006860-a3b8hyyr	1925	15	atter	atter	NN
cord-006860-a3b8hyyr	1925	16	the	the	DT
cord-006860-a3b8hyyr	1925	17	maximum	maximum	JJ
cord-006860-a3b8hyyr	1925	18	amplitude	amplitude	NN
cord-006860-a3b8hyyr	1925	19	is	be	VBZ
cord-006860-a3b8hyyr	1925	20	reached	reach	VBN
cord-006860-a3b8hyyr	1925	21	.	.	.
cord-006860-a3b8hyyr	1926	1	This	this	DT
cord-006860-a3b8hyyr	1926	2	takes	take	VBZ
cord-006860-a3b8hyyr	1926	3	a	a	DT
cord-006860-a3b8hyyr	1926	4	considerable	considerable	JJ
cord-006860-a3b8hyyr	1926	5	amount	amount	NN
cord-006860-a3b8hyyr	1926	6	of	of	IN
cord-006860-a3b8hyyr	1926	7	time	time	NN
cord-006860-a3b8hyyr	1926	8	(	(	-LRB-
cord-006860-a3b8hyyr	1926	9	more	more	JJR
cord-006860-a3b8hyyr	1926	10	than	than	IN
cord-006860-a3b8hyyr	1926	11	30	30	CD
cord-006860-a3b8hyyr	1926	12	minutes	minute	NNS
cord-006860-a3b8hyyr	1926	13	)	)	-RRB-
cord-006860-a3b8hyyr	1926	14	.	.	.
cord-006860-a3b8hyyr	1927	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	1927	2	approach	approach	NN
cord-006860-a3b8hyyr	1927	3	bases	basis	NNS
cord-006860-a3b8hyyr	1927	4	on	on	IN
cord-006860-a3b8hyyr	1927	5	the	the	DT
cord-006860-a3b8hyyr	1927	6	understanding	understanding	NN
cord-006860-a3b8hyyr	1927	7	of	of	IN
cord-006860-a3b8hyyr	1927	8	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1927	9	as	as	IN
cord-006860-a3b8hyyr	1927	10	a	a	DT
cord-006860-a3b8hyyr	1927	11	process	process	NN
cord-006860-a3b8hyyr	1927	12	which	which	WDT
cord-006860-a3b8hyyr	1927	13	runs	run	VBZ
cord-006860-a3b8hyyr	1927	14	in	in	IN
cord-006860-a3b8hyyr	1927	15	paraUe	paraUe	NNP
cord-006860-a3b8hyyr	1927	16	[	[	-LRB-
cord-006860-a3b8hyyr	1927	17	to	to	IN
cord-006860-a3b8hyyr	1927	18	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1927	19	and	and	CC
cord-006860-a3b8hyyr	1927	20	is	be	VBZ
cord-006860-a3b8hyyr	1927	21	not	not	RB
cord-006860-a3b8hyyr	1927	22	exclusively	exclusively	RB
cord-006860-a3b8hyyr	1927	23	subsidiary	subsidiary	JJ
cord-006860-a3b8hyyr	1927	24	to	to	IN
cord-006860-a3b8hyyr	1927	25	it	-PRON-	PRP
cord-006860-a3b8hyyr	1927	26	.	.	.
cord-006860-a3b8hyyr	1928	1	The	the	DT
cord-006860-a3b8hyyr	1928	2	effect	effect	NN
cord-006860-a3b8hyyr	1928	3	of	of	IN
cord-006860-a3b8hyyr	1928	4	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1928	5	on	on	IN
cord-006860-a3b8hyyr	1928	6	the	the	DT
cord-006860-a3b8hyyr	1928	7	growing	grow	VBG
cord-006860-a3b8hyyr	1928	8	clot	clot	NN
cord-006860-a3b8hyyr	1928	9	in	in	IN
cord-006860-a3b8hyyr	1928	10	the	the	DT
cord-006860-a3b8hyyr	1928	11	TEG	TEG	NNP
cord-006860-a3b8hyyr	1928	12	is	be	VBZ
cord-006860-a3b8hyyr	1928	13	shown	show	VBN
cord-006860-a3b8hyyr	1928	14	by	by	IN
cord-006860-a3b8hyyr	1928	15	the	the	DT
cord-006860-a3b8hyyr	1928	16	comparison	comparison	NN
cord-006860-a3b8hyyr	1928	17	of	of	IN
cord-006860-a3b8hyyr	1928	18	two	two	CD
cord-006860-a3b8hyyr	1928	19	parallely	parallely	NNP
cord-006860-a3b8hyyr	1928	20	performed	perform	VBN
cord-006860-a3b8hyyr	1928	21	TEG	TEG	NNP
cord-006860-a3b8hyyr	1928	22	measurements	measurement	NNS
cord-006860-a3b8hyyr	1928	23	:	:	:
cord-006860-a3b8hyyr	1928	24	ExTEG	exteg	NN
cord-006860-a3b8hyyr	1928	25	:	:	:
cord-006860-a3b8hyyr	1929	1	TEG	TEG	NNP
cord-006860-a3b8hyyr	1929	2	measurement	measurement	NN
cord-006860-a3b8hyyr	1929	3	with	with	IN
cord-006860-a3b8hyyr	1929	4	standardised	standardised	JJ
cord-006860-a3b8hyyr	1929	5	activation	activation	NN
cord-006860-a3b8hyyr	1929	6	of	of	IN
cord-006860-a3b8hyyr	1929	7	the	the	DT
cord-006860-a3b8hyyr	1929	8	extrinsic	extrinsic	JJ
cord-006860-a3b8hyyr	1929	9	system	system	NN
cord-006860-a3b8hyyr	1929	10	.	.	.
cord-006860-a3b8hyyr	1930	1	ApTEG	ApTEG	NNP
cord-006860-a3b8hyyr	1930	2	:	:	:
cord-006860-a3b8hyyr	1930	3	ExTEG	exteg	NN
cord-006860-a3b8hyyr	1931	1	with	with	IN
cord-006860-a3b8hyyr	1931	2	in	in	IN
cord-006860-a3b8hyyr	1931	3	-	-	HYPH
cord-006860-a3b8hyyr	1931	4	vitro	vitro	FW
cord-006860-a3b8hyyr	1931	5	-	-	HYPH
cord-006860-a3b8hyyr	1931	6	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1931	7	inhibition	inhibition	NN
cord-006860-a3b8hyyr	1931	8	via	via	IN
cord-006860-a3b8hyyr	1931	9	aprotinin	aprotinin	NNP
cord-006860-a3b8hyyr	1931	10	.	.	.
cord-006860-a3b8hyyr	1932	1	ExTEG	ExTEG	NNP
cord-006860-a3b8hyyr	1932	2	-	-	HYPH
cord-006860-a3b8hyyr	1932	3	Reagent	Reagent	NNP
cord-006860-a3b8hyyr	1932	4	(	(	-LRB-
cord-006860-a3b8hyyr	1932	5	Ex	Ex	NNP
cord-006860-a3b8hyyr	1932	6	)	)	-RRB-
cord-006860-a3b8hyyr	1932	7	:	:	:
cord-006860-a3b8hyyr	1932	8	1:2	1:2	CD
cord-006860-a3b8hyyr	1932	9	dilution	dilution	NN
cord-006860-a3b8hyyr	1932	10	of	of	IN
cord-006860-a3b8hyyr	1932	11	Innovin	Innovin	NNP
cord-006860-a3b8hyyr	1932	12	(	(	-LRB-
cord-006860-a3b8hyyr	1932	13	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	1932	14	thromboplastin	thromboplastin	NN
cord-006860-a3b8hyyr	1932	15	reagent	reagent	NN
cord-006860-a3b8hyyr	1932	16	,	,	,
cord-006860-a3b8hyyr	1932	17	Dade	Dade	NNP
cord-006860-a3b8hyyr	1932	18	)	)	-RRB-
cord-006860-a3b8hyyr	1932	19	with	with	IN
cord-006860-a3b8hyyr	1932	20	aqua	aqua	NNP
cord-006860-a3b8hyyr	1932	21	dest	dest	NNP
cord-006860-a3b8hyyr	1932	22	.	.	.
cord-006860-a3b8hyyr	1933	1	ApTEG	ApTEG	NNP
cord-006860-a3b8hyyr	1933	2	-	-	HYPH
cord-006860-a3b8hyyr	1933	3	Reagent	Reagent	NNP
cord-006860-a3b8hyyr	1933	4	(	(	-LRB-
cord-006860-a3b8hyyr	1933	5	Ap	Ap	NNP
cord-006860-a3b8hyyr	1933	6	)	)	-RRB-
cord-006860-a3b8hyyr	1933	7	:	:	:
cord-006860-a3b8hyyr	1933	8	5	5	CD
cord-006860-a3b8hyyr	1933	9	parts	part	NNS
cord-006860-a3b8hyyr	1933	10	Innovin	Innovin	NNP
cord-006860-a3b8hyyr	1933	11	,	,	,
cord-006860-a3b8hyyr	1933	12	2	2	CD
cord-006860-a3b8hyyr	1933	13	parts	part	NNS
cord-006860-a3b8hyyr	1933	14	Trasy[ol	Trasy[ol	NNP
cord-006860-a3b8hyyr	1933	15	(	(	-LRB-
cord-006860-a3b8hyyr	1933	16	Aprotinin	Aprotinin	NNP
cord-006860-a3b8hyyr	1933	17	,	,	,
cord-006860-a3b8hyyr	1933	18	Bayer	Bayer	NNP
cord-006860-a3b8hyyr	1933	19	,	,	,
cord-006860-a3b8hyyr	1933	20	I0.000	I0.000	NNP
cord-006860-a3b8hyyr	1933	21	KIE	KIE	NNP
cord-006860-a3b8hyyr	1933	22	/	/	SYM
cord-006860-a3b8hyyr	1933	23	ml	ml	NNP
cord-006860-a3b8hyyr	1933	24	)	)	-RRB-
cord-006860-a3b8hyyr	1933	25	,	,	,
cord-006860-a3b8hyyr	1933	26	3	3	CD
cord-006860-a3b8hyyr	1933	27	parts	part	NNS
cord-006860-a3b8hyyr	1933	28	aqua	aqua	NN
cord-006860-a3b8hyyr	1933	29	dest	dest	NN
cord-006860-a3b8hyyr	1933	30	.	.	.
cord-006860-a3b8hyyr	1934	1	Test	test	NN
cord-006860-a3b8hyyr	1934	2	procedure	procedure	NN
cord-006860-a3b8hyyr	1934	3	:	:	:
cord-006860-a3b8hyyr	1935	1	l0	l0	NNP
cord-006860-a3b8hyyr	1935	2	p1	p1	NNP
cord-006860-a3b8hyyr	1935	3	Ex	Ex	NNP
cord-006860-a3b8hyyr	1935	4	or	or	CC
cord-006860-a3b8hyyr	1935	5	Ap	Ap	NNP
cord-006860-a3b8hyyr	1936	1	+	+	SYM
cord-006860-a3b8hyyr	1936	2	300	300	CD
cord-006860-a3b8hyyr	1936	3	~l	~l	NNP
cord-006860-a3b8hyyr	1936	4	citrated	citrate	VBD
cord-006860-a3b8hyyr	1936	5	blood	blood	NN
cord-006860-a3b8hyyr	1936	6	(	(	-LRB-
cord-006860-a3b8hyyr	1936	7	CB	CB	NNP
cord-006860-a3b8hyyr	1936	8	)	)	-RRB-
cord-006860-a3b8hyyr	1937	1	+	+	CC
cord-006860-a3b8hyyr	1938	1	50	50	CD
cord-006860-a3b8hyyr	1938	2	lal	lal	NNP
cord-006860-a3b8hyyr	1938	3	CaCl2-solution	CaCl2-solution	NNP
cord-006860-a3b8hyyr	1938	4	0,15	0,15	NNP
cord-006860-a3b8hyyr	1938	5	M.	M.	NNP
cord-006860-a3b8hyyr	1939	1	The	the	DT
cord-006860-a3b8hyyr	1939	2	only	only	JJ
cord-006860-a3b8hyyr	1939	3	difference	difference	NN
cord-006860-a3b8hyyr	1939	4	of	of	IN
cord-006860-a3b8hyyr	1939	5	the	the	DT
cord-006860-a3b8hyyr	1939	6	two	two	CD
cord-006860-a3b8hyyr	1939	7	reagents	reagent	NNS
cord-006860-a3b8hyyr	1939	8	is	be	VBZ
cord-006860-a3b8hyyr	1939	9	the	the	DT
cord-006860-a3b8hyyr	1939	10	addition	addition	NN
cord-006860-a3b8hyyr	1939	11	of	of	IN
cord-006860-a3b8hyyr	1939	12	20	20	CD
cord-006860-a3b8hyyr	1939	13	KIE	KIE	NNP
cord-006860-a3b8hyyr	1939	14	Aprotinin	Aprotinin	NNP
cord-006860-a3b8hyyr	1939	15	in	in	IN
cord-006860-a3b8hyyr	1939	16	the	the	DT
cord-006860-a3b8hyyr	1939	17	ApTEG	ApTEG	NNP
cord-006860-a3b8hyyr	1939	18	,	,	,
cord-006860-a3b8hyyr	1939	19	leading	lead	VBG
cord-006860-a3b8hyyr	1939	20	to	to	IN
cord-006860-a3b8hyyr	1939	21	an	an	DT
cord-006860-a3b8hyyr	1939	22	in	in	IN
cord-006860-a3b8hyyr	1939	23	-	-	HYPH
cord-006860-a3b8hyyr	1939	24	vitro	vitro	FW
cord-006860-a3b8hyyr	1939	25	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1939	26	inhibition	inhibition	NN
cord-006860-a3b8hyyr	1939	27	.	.	.
cord-006860-a3b8hyyr	1940	1	The	the	DT
cord-006860-a3b8hyyr	1940	2	usage	usage	NN
cord-006860-a3b8hyyr	1940	3	of	of	IN
cord-006860-a3b8hyyr	1940	4	disposable	disposable	JJ
cord-006860-a3b8hyyr	1940	5	pins	pin	NNS
cord-006860-a3b8hyyr	1940	6	and	and	CC
cord-006860-a3b8hyyr	1940	7	cups	cup	NNS
cord-006860-a3b8hyyr	1940	8	(	(	-LRB-
cord-006860-a3b8hyyr	1940	9	Haemoscope	Haemoscope	NNP
cord-006860-a3b8hyyr	1940	10	,	,	,
cord-006860-a3b8hyyr	1940	11	Illinois	Illinois	NNP
cord-006860-a3b8hyyr	1940	12	,	,	,
cord-006860-a3b8hyyr	1940	13	USA	USA	NNP
cord-006860-a3b8hyyr	1940	14	/	/	SYM
cord-006860-a3b8hyyr	1940	15	E.M.S.	E.M.S.	NNP
cord-006860-a3b8hyyr	1940	16	,	,	,
cord-006860-a3b8hyyr	1940	17	Vienna	Vienna	NNP
cord-006860-a3b8hyyr	1940	18	)	)	-RRB-
cord-006860-a3b8hyyr	1940	19	is	be	VBZ
cord-006860-a3b8hyyr	1940	20	recommended	recommend	VBN
cord-006860-a3b8hyyr	1940	21	for	for	IN
cord-006860-a3b8hyyr	1940	22	ensuring	ensure	VBG
cord-006860-a3b8hyyr	1940	23	standardised	standardised	JJ
cord-006860-a3b8hyyr	1940	24	conditions	condition	NNS
cord-006860-a3b8hyyr	1940	25	for	for	IN
cord-006860-a3b8hyyr	1940	26	both	both	DT
cord-006860-a3b8hyyr	1940	27	measurements	measurement	NNS
cord-006860-a3b8hyyr	1940	28	.	.	.
cord-006860-a3b8hyyr	1941	1	Results	result	NNS
cord-006860-a3b8hyyr	1941	2	and	and	CC
cord-006860-a3b8hyyr	1941	3	discussion	discussion	NN
cord-006860-a3b8hyyr	1941	4	:	:	:
cord-006860-a3b8hyyr	1941	5	When	when	WRB
cord-006860-a3b8hyyr	1941	6	there	there	EX
cord-006860-a3b8hyyr	1941	7	is	be	VBZ
cord-006860-a3b8hyyr	1941	8	a	a	DT
cord-006860-a3b8hyyr	1941	9	better	well	JJR
cord-006860-a3b8hyyr	1941	10	clot	clot	NN
cord-006860-a3b8hyyr	1941	11	formation	formation	NN
cord-006860-a3b8hyyr	1941	12	in	in	IN
cord-006860-a3b8hyyr	1941	13	the	the	DT
cord-006860-a3b8hyyr	1941	14	ApTEG	ApTEG	NNP
cord-006860-a3b8hyyr	1941	15	(	(	-LRB-
cord-006860-a3b8hyyr	1941	16	corresponding	correspond	VBG
cord-006860-a3b8hyyr	1941	17	to	to	IN
cord-006860-a3b8hyyr	1941	18	a	a	DT
cord-006860-a3b8hyyr	1941	19	lower	low	JJR
cord-006860-a3b8hyyr	1941	20	so	so	RB
cord-006860-a3b8hyyr	1941	21	-	-	HYPH
cord-006860-a3b8hyyr	1941	22	cafled	cafle	VBN
cord-006860-a3b8hyyr	1941	23	K	K	NNP
cord-006860-a3b8hyyr	1941	24	-	-	HYPH
cord-006860-a3b8hyyr	1941	25	value	value	NN
cord-006860-a3b8hyyr	1941	26	)	)	-RRB-
cord-006860-a3b8hyyr	1941	27	than	than	IN
cord-006860-a3b8hyyr	1941	28	in	in	IN
cord-006860-a3b8hyyr	1941	29	the	the	DT
cord-006860-a3b8hyyr	1941	30	ExTEG	ExTEG	NNP
cord-006860-a3b8hyyr	1941	31	,	,	,
cord-006860-a3b8hyyr	1941	32	fibdnolysis	fibdnolysis	NN
cord-006860-a3b8hyyr	1941	33	can	can	MD
cord-006860-a3b8hyyr	1941	34	be	be	VB
cord-006860-a3b8hyyr	1941	35	suspected	suspect	VBN
cord-006860-a3b8hyyr	1941	36	.	.	.
cord-006860-a3b8hyyr	1942	1	This	this	DT
cord-006860-a3b8hyyr	1942	2	technique	technique	NN
cord-006860-a3b8hyyr	1942	3	requires	require	VBZ
cord-006860-a3b8hyyr	1942	4	only	only	RB
cord-006860-a3b8hyyr	1942	5	commercially	commercially	RB
cord-006860-a3b8hyyr	1942	6	available	available	JJ
cord-006860-a3b8hyyr	1942	7	reagents	reagent	NNS
cord-006860-a3b8hyyr	1942	8	and	and	CC
cord-006860-a3b8hyyr	1942	9	is	be	VBZ
cord-006860-a3b8hyyr	1942	10	easy	easy	JJ
cord-006860-a3b8hyyr	1942	11	to	to	TO
cord-006860-a3b8hyyr	1942	12	perform	perform	VB
cord-006860-a3b8hyyr	1942	13	on	on	IN
cord-006860-a3b8hyyr	1942	14	conventional	conventional	JJ
cord-006860-a3b8hyyr	1942	15	TEG	TEG	NNP
cord-006860-a3b8hyyr	1942	16	systems	system	NNS
cord-006860-a3b8hyyr	1942	17	.	.	.
cord-006860-a3b8hyyr	1943	1	Due	due	IN
cord-006860-a3b8hyyr	1943	2	to	to	IN
cord-006860-a3b8hyyr	1943	3	the	the	DT
cord-006860-a3b8hyyr	1943	4	standardised	standardised	JJ
cord-006860-a3b8hyyr	1943	5	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1943	6	activation	activation	NN
cord-006860-a3b8hyyr	1943	7	with	with	IN
cord-006860-a3b8hyyr	1943	8	a	a	DT
cord-006860-a3b8hyyr	1943	9	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	1943	10	reagent	reagent	NN
cord-006860-a3b8hyyr	1943	11	,	,	,
cord-006860-a3b8hyyr	1943	12	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1943	13	can	can	MD
cord-006860-a3b8hyyr	1943	14	be	be	VB
cord-006860-a3b8hyyr	1943	15	detected	detect	VBN
cord-006860-a3b8hyyr	1943	16	also	also	RB
cord-006860-a3b8hyyr	1943	17	when	when	WRB
cord-006860-a3b8hyyr	1943	18	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1943	19	like	like	IN
cord-006860-a3b8hyyr	1943	20	heparin	heparin	NN
cord-006860-a3b8hyyr	1943	21	are	be	VBP
cord-006860-a3b8hyyr	1943	22	present	present	JJ
cord-006860-a3b8hyyr	1943	23	in	in	IN
cord-006860-a3b8hyyr	1943	24	the	the	DT
cord-006860-a3b8hyyr	1943	25	circulation	circulation	NN
cord-006860-a3b8hyyr	1943	26	.	.	.
cord-006860-a3b8hyyr	1944	1	According	accord	VBG
cord-006860-a3b8hyyr	1944	2	to	to	IN
cord-006860-a3b8hyyr	1944	3	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1944	4	experience	experience	NN
cord-006860-a3b8hyyr	1944	5	using	use	VBG
cord-006860-a3b8hyyr	1944	6	this	this	DT
cord-006860-a3b8hyyr	1944	7	technique	technique	NN
cord-006860-a3b8hyyr	1944	8	during	during	IN
cord-006860-a3b8hyyr	1944	9	liver	liver	NN
cord-006860-a3b8hyyr	1944	10	transplantation	transplantation	NN
cord-006860-a3b8hyyr	1944	11	,	,	,
cord-006860-a3b8hyyr	1944	12	clinical	clinical	JJ
cord-006860-a3b8hyyr	1944	13	relevant	relevant	JJ
cord-006860-a3b8hyyr	1944	14	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	1944	15	can	can	MD
cord-006860-a3b8hyyr	1944	16	be	be	VB
cord-006860-a3b8hyyr	1944	17	detected	detect	VBN
cord-006860-a3b8hyyr	1944	18	as	as	IN
cord-006860-a3b8hyyr	1944	19	described	describe	VBN
cord-006860-a3b8hyyr	1944	20	in	in	IN
cord-006860-a3b8hyyr	1944	21	less	less	JJR
cord-006860-a3b8hyyr	1944	22	than	than	IN
cord-006860-a3b8hyyr	1944	23	l0	l0	NNP
cord-006860-a3b8hyyr	1944	24	minutes	minute	NNS
cord-006860-a3b8hyyr	1944	25	.	.	.
cord-006860-a3b8hyyr	1945	1	Many	many	JJ
cord-006860-a3b8hyyr	1945	2	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	1945	3	(	(	-LRB-
cord-006860-a3b8hyyr	1945	4	massive	massive	JJ
cord-006860-a3b8hyyr	1945	5	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	1945	6	embolism	embolism	NN
cord-006860-a3b8hyyr	1945	7	,	,	,
cord-006860-a3b8hyyr	1945	8	proximal	proximal	JJ
cord-006860-a3b8hyyr	1945	9	deepvein	deepvein	NN
cord-006860-a3b8hyyr	1945	10	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	1945	11	,	,	,
cord-006860-a3b8hyyr	1945	12	etc	etc	FW
cord-006860-a3b8hyyr	1945	13	.	.	.
cord-006860-a3b8hyyr	1945	14	)	)	-RRB-
cord-006860-a3b8hyyr	1945	15	and	and	CC
cord-006860-a3b8hyyr	1945	16	coronary	coronary	JJ
cord-006860-a3b8hyyr	1945	17	diseases	disease	NNS
cord-006860-a3b8hyyr	1945	18	(	(	-LRB-
cord-006860-a3b8hyyr	1945	19	infarction	infarction	NN
cord-006860-a3b8hyyr	1945	20	,	,	,
cord-006860-a3b8hyyr	1945	21	acute	acute	JJ
cord-006860-a3b8hyyr	1945	22	phase	phase	NN
cord-006860-a3b8hyyr	1945	23	,	,	,
cord-006860-a3b8hyyr	1945	24	etc	etc	FW
cord-006860-a3b8hyyr	1945	25	.	.	.
cord-006860-a3b8hyyr	1945	26	)	)	-RRB-
cord-006860-a3b8hyyr	1945	27	require	require	VB
cord-006860-a3b8hyyr	1945	28	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1945	29	therapy	therapy	NN
cord-006860-a3b8hyyr	1945	30	to	to	IN
cord-006860-a3b8hyyr	1945	31	early	early	JJ
cord-006860-a3b8hyyr	1945	32	recanalizafion	recanalizafion	NN
cord-006860-a3b8hyyr	1945	33	.	.	.
cord-006860-a3b8hyyr	1946	1	The	the	DT
cord-006860-a3b8hyyr	1946	2	application	application	NN
cord-006860-a3b8hyyr	1946	3	of	of	IN
cord-006860-a3b8hyyr	1946	4	the	the	DT
cord-006860-a3b8hyyr	1946	5	well	well	RB
cord-006860-a3b8hyyr	1946	6	-	-	HYPH
cord-006860-a3b8hyyr	1946	7	known	know	VBN
cord-006860-a3b8hyyr	1946	8	or	or	CC
cord-006860-a3b8hyyr	1946	9	new	new	JJ
cord-006860-a3b8hyyr	1946	10	thrombolytic	thrombolytic	JJ
cord-006860-a3b8hyyr	1946	11	agents	agent	NNS
cord-006860-a3b8hyyr	1946	12	needs	need	VBZ
cord-006860-a3b8hyyr	1946	13	the	the	DT
cord-006860-a3b8hyyr	1946	14	use	use	NN
cord-006860-a3b8hyyr	1946	15	of	of	IN
cord-006860-a3b8hyyr	1946	16	specific	specific	JJ
cord-006860-a3b8hyyr	1946	17	,	,	,
cord-006860-a3b8hyyr	1946	18	simple	simple	JJ
cord-006860-a3b8hyyr	1946	19	and	and	CC
cord-006860-a3b8hyyr	1946	20	reproducible	reproducible	JJ
cord-006860-a3b8hyyr	1946	21	methods	method	NNS
cord-006860-a3b8hyyr	1946	22	for	for	IN
cord-006860-a3b8hyyr	1946	23	the	the	DT
cord-006860-a3b8hyyr	1946	24	determination	determination	NN
cord-006860-a3b8hyyr	1946	25	of	of	IN
cord-006860-a3b8hyyr	1946	26	fibdnolyfic	fibdnolyfic	NN
cord-006860-a3b8hyyr	1946	27	activity	activity	NN
cord-006860-a3b8hyyr	1946	28	.	.	.
cord-006860-a3b8hyyr	1947	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1947	2	suggest	suggest	VBP
cord-006860-a3b8hyyr	1947	3	new	new	JJ
cord-006860-a3b8hyyr	1947	4	methods	method	NNS
cord-006860-a3b8hyyr	1947	5	for	for	IN
cord-006860-a3b8hyyr	1947	6	measuring	measure	VBG
cord-006860-a3b8hyyr	1947	7	the	the	DT
cord-006860-a3b8hyyr	1947	8	blood	blood	NN
cord-006860-a3b8hyyr	1947	9	plasma	plasma	NN
cord-006860-a3b8hyyr	1947	10	concentrations	concentration	NNS
cord-006860-a3b8hyyr	1947	11	of	of	IN
cord-006860-a3b8hyyr	1947	12	plasmin	plasmin	NN
cord-006860-a3b8hyyr	1947	13	,	,	,
cord-006860-a3b8hyyr	1947	14	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	1947	15	,	,	,
cord-006860-a3b8hyyr	1947	16	antiplasmins	antiplasmin	NNS
cord-006860-a3b8hyyr	1947	17	,	,	,
cord-006860-a3b8hyyr	1947	18	and	and	CC
cord-006860-a3b8hyyr	1947	19	urine	urine	NN
cord-006860-a3b8hyyr	1947	20	urokinase	urokinase	NN
cord-006860-a3b8hyyr	1947	21	activity	activity	NN
cord-006860-a3b8hyyr	1947	22	.	.	.
cord-006860-a3b8hyyr	1948	1	These	these	DT
cord-006860-a3b8hyyr	1948	2	methods	method	NNS
cord-006860-a3b8hyyr	1948	3	involve	involve	VBP
cord-006860-a3b8hyyr	1948	4	the	the	DT
cord-006860-a3b8hyyr	1948	5	employment	employment	NN
cord-006860-a3b8hyyr	1948	6	of	of	IN
cord-006860-a3b8hyyr	1948	7	chromogenic	chromogenic	NNP
cord-006860-a3b8hyyr	1948	8	substrafe	substrafe	NNP
cord-006860-a3b8hyyr	1948	9	azofibrin	azofibrin	NNP
cord-006860-a3b8hyyr	1948	10	(	(	-LRB-
cord-006860-a3b8hyyr	1948	11	human	human	JJ
cord-006860-a3b8hyyr	1948	12	fibrin	fibrin	NN
cord-006860-a3b8hyyr	1948	13	,	,	,
cord-006860-a3b8hyyr	1948	14	covalently	covalently	RB
cord-006860-a3b8hyyr	1948	15	labeled	label	VBN
cord-006860-a3b8hyyr	1948	16	with	with	IN
cord-006860-a3b8hyyr	1948	17	p	p	NN
cord-006860-a3b8hyyr	1948	18	-	-	HYPH
cord-006860-a3b8hyyr	1948	19	diazobenzenesulfonic	diazobenzenesulfonic	NNP
cord-006860-a3b8hyyr	1948	20	acid	acid	NN
cord-006860-a3b8hyyr	1948	21	)	)	-RRB-
cord-006860-a3b8hyyr	1948	22	.	.	.
cord-006860-a3b8hyyr	1949	1	Method~.	Method~.	NFP
cord-006860-a3b8hyyr	1949	2	0.2	0.2	CD
cord-006860-a3b8hyyr	1949	3	ml	ml	NNS
cord-006860-a3b8hyyr	1949	4	of	of	IN
cord-006860-a3b8hyyr	1949	5	studied	studied	JJ
cord-006860-a3b8hyyr	1949	6	solution	solution	NN
cord-006860-a3b8hyyr	1949	7	was	be	VBD
cord-006860-a3b8hyyr	1949	8	added	add	VBN
cord-006860-a3b8hyyr	1949	9	to	to	IN
cord-006860-a3b8hyyr	1949	10	0,8	0,8	CD
cord-006860-a3b8hyyr	1949	11	ml	ml	XX
cord-006860-a3b8hyyr	1949	12	of	of	IN
cord-006860-a3b8hyyr	1949	13	azofibrin	azofibrin	NNP
cord-006860-a3b8hyyr	1949	14	suspension	suspension	NN
cord-006860-a3b8hyyr	1949	15	in	in	IN
cord-006860-a3b8hyyr	1949	16	certain	certain	JJ
cord-006860-a3b8hyyr	1949	17	buffer	buffer	NN
cord-006860-a3b8hyyr	1949	18	(	(	-LRB-
cord-006860-a3b8hyyr	1949	19	5	5	CD
cord-006860-a3b8hyyr	1949	20	-	-	SYM
cord-006860-a3b8hyyr	1949	21	10	10	CD
cord-006860-a3b8hyyr	1949	22	mg	mg	NNP
cord-006860-a3b8hyyr	1949	23	/	/	SYM
cord-006860-a3b8hyyr	1949	24	ml	ml	NNP
cord-006860-a3b8hyyr	1949	25	)	)	-RRB-
cord-006860-a3b8hyyr	1949	26	and	and	CC
cord-006860-a3b8hyyr	1949	27	the	the	DT
cord-006860-a3b8hyyr	1949	28	mixture	mixture	NN
cord-006860-a3b8hyyr	1949	29	incubated	incubate	VBN
cord-006860-a3b8hyyr	1949	30	at	at	IN
cord-006860-a3b8hyyr	1949	31	37	37	CD
cord-006860-a3b8hyyr	1949	32	oc	oc	NN
cord-006860-a3b8hyyr	1949	33	for	for	IN
cord-006860-a3b8hyyr	1949	34	10	10	CD
cord-006860-a3b8hyyr	1949	35	-	-	SYM
cord-006860-a3b8hyyr	1949	36	60	60	CD
cord-006860-a3b8hyyr	1949	37	rain	rain	NN
cord-006860-a3b8hyyr	1949	38	.	.	.
cord-006860-a3b8hyyr	1950	1	After	after	IN
cord-006860-a3b8hyyr	1950	2	the	the	DT
cord-006860-a3b8hyyr	1950	3	end	end	NN
cord-006860-a3b8hyyr	1950	4	of	of	IN
cord-006860-a3b8hyyr	1950	5	incubation	incubation	NN
cord-006860-a3b8hyyr	1950	6	the	the	DT
cord-006860-a3b8hyyr	1950	7	mixture	mixture	NN
cord-006860-a3b8hyyr	1950	8	was	be	VBD
cord-006860-a3b8hyyr	1950	9	filtered	filter	VBN
cord-006860-a3b8hyyr	1950	10	,	,	,
cord-006860-a3b8hyyr	1950	11	the	the	DT
cord-006860-a3b8hyyr	1950	12	volume	volume	NN
cord-006860-a3b8hyyr	1950	13	of	of	IN
cord-006860-a3b8hyyr	1950	14	solution	solution	NN
cord-006860-a3b8hyyr	1950	15	brought	bring	VBN
cord-006860-a3b8hyyr	1950	16	up	up	RP
cord-006860-a3b8hyyr	1950	17	to	to	TO
cord-006860-a3b8hyyr	1950	18	4	4	CD
cord-006860-a3b8hyyr	1950	19	ml	ml	NNS
cord-006860-a3b8hyyr	1950	20	by	by	IN
cord-006860-a3b8hyyr	1950	21	0.02	0.02	CD
cord-006860-a3b8hyyr	1950	22	M	M	NNP
cord-006860-a3b8hyyr	1950	23	NaOH	NaOH	NNP
cord-006860-a3b8hyyr	1950	24	and	and	CC
cord-006860-a3b8hyyr	1950	25	the	the	DT
cord-006860-a3b8hyyr	1950	26	optical	optical	JJ
cord-006860-a3b8hyyr	1950	27	density	density	NN
cord-006860-a3b8hyyr	1950	28	was	be	VBD
cord-006860-a3b8hyyr	1950	29	determined	determine	VBN
cord-006860-a3b8hyyr	1950	30	at	at	IN
cord-006860-a3b8hyyr	1950	31	440	440	CD
cord-006860-a3b8hyyr	1950	32	nm	nm	NN
cord-006860-a3b8hyyr	1950	33	.	.	.
cord-006860-a3b8hyyr	1951	1	Resuffs	Resuffs	NNP
cord-006860-a3b8hyyr	1951	2	.	.	.
cord-006860-a3b8hyyr	1952	1	Azofibrin	Azofibrin	NNP
cord-006860-a3b8hyyr	1952	2	can	can	MD
cord-006860-a3b8hyyr	1952	3	be	be	VB
cord-006860-a3b8hyyr	1952	4	used	use	VBN
cord-006860-a3b8hyyr	1952	5	for	for	IN
cord-006860-a3b8hyyr	1952	6	quantitative	quantitative	JJ
cord-006860-a3b8hyyr	1952	7	determination	determination	NN
cord-006860-a3b8hyyr	1952	8	of	of	IN
cord-006860-a3b8hyyr	1952	9	proteinases	proteinases	NNP
cord-006860-a3b8hyyr	1952	10	activity	activity	NN
cord-006860-a3b8hyyr	1952	11	in	in	IN
cord-006860-a3b8hyyr	1952	12	search	search	NN
cord-006860-a3b8hyyr	1952	13	of	of	IN
cord-006860-a3b8hyyr	1952	14	new	new	JJ
cord-006860-a3b8hyyr	1952	15	fibrinolytic	fibrinolytic	NN
cord-006860-a3b8hyyr	1952	16	means	mean	NNS
cord-006860-a3b8hyyr	1952	17	.	.	.
cord-006860-a3b8hyyr	1953	1	For	for	IN
cord-006860-a3b8hyyr	1953	2	comparison	comparison	NN
cord-006860-a3b8hyyr	1953	3	the	the	DT
cord-006860-a3b8hyyr	1953	4	results	result	NNS
cord-006860-a3b8hyyr	1953	5	of	of	IN
cord-006860-a3b8hyyr	1953	6	our	-PRON-	PRP$
cord-006860-a3b8hyyr	1953	7	studies	study	NNS
cord-006860-a3b8hyyr	1953	8	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1953	9	activity	activity	NN
cord-006860-a3b8hyyr	1953	10	of	of	IN
cord-006860-a3b8hyyr	1953	11	some	some	DT
cord-006860-a3b8hyyr	1953	12	proteinases	proteinase	NNS
cord-006860-a3b8hyyr	1953	13	with	with	IN
cord-006860-a3b8hyyr	1953	14	the	the	DT
cord-006860-a3b8hyyr	1953	15	use	use	NN
cord-006860-a3b8hyyr	1953	16	of	of	IN
cord-006860-a3b8hyyr	1953	17	azofibrin	azofibrin	NNP
cord-006860-a3b8hyyr	1953	18	are	be	VBP
cord-006860-a3b8hyyr	1953	19	presented	present	VBN
cord-006860-a3b8hyyr	1953	20	:	:	:
cord-006860-a3b8hyyr	1953	21	Activity	activity	NN
cord-006860-a3b8hyyr	1953	22	.	.	.
cord-006860-a3b8hyyr	1954	1	with	with	IN
cord-006860-a3b8hyyr	1954	2	an	an	DT
cord-006860-a3b8hyyr	1954	3	increase	increase	NN
cord-006860-a3b8hyyr	1954	4	of	of	IN
cord-006860-a3b8hyyr	1954	5	PAl	PAl	NNS
cord-006860-a3b8hyyr	1954	6	and	and	CC
cord-006860-a3b8hyyr	1954	7	LDL	ldl	NN
cord-006860-a3b8hyyr	1954	8	-	-	:
cord-006860-a3b8hyyr	1954	9	and	and	CC
cord-006860-a3b8hyyr	1954	10	a	a	DT
cord-006860-a3b8hyyr	1954	11	decrease	decrease	NN
cord-006860-a3b8hyyr	1954	12	of	of	IN
cord-006860-a3b8hyyr	1954	13	HDL	hdl	NN
cord-006860-a3b8hyyr	1954	14	-	-	HYPH
cord-006860-a3b8hyyr	1954	15	cholesterol	cholesterol	NN
cord-006860-a3b8hyyr	1954	16	concentrations	concentration	NNS
cord-006860-a3b8hyyr	1955	1	k	k	NNP
cord-006860-a3b8hyyr	1955	2	is	be	VBZ
cord-006860-a3b8hyyr	1955	3	concluded	conclude	VBN
cord-006860-a3b8hyyr	1955	4	that	that	IN
cord-006860-a3b8hyyr	1955	5	the	the	DT
cord-006860-a3b8hyyr	1955	6	increased	increase	VBN
cord-006860-a3b8hyyr	1955	7	cardiovascular	cardiovascular	JJ
cord-006860-a3b8hyyr	1955	8	risk	risk	NN
cord-006860-a3b8hyyr	1955	9	in	in	IN
cord-006860-a3b8hyyr	1955	10	diabetes	diabetes	NN
cord-006860-a3b8hyyr	1955	11	meilitus	meilitus	NNP
cord-006860-a3b8hyyr	1955	12	was	be	VBD
cord-006860-a3b8hyyr	1955	13	partly	partly	RB
cord-006860-a3b8hyyr	1955	14	caused	cause	VBN
cord-006860-a3b8hyyr	1955	15	by	by	IN
cord-006860-a3b8hyyr	1955	16	a	a	DT
cord-006860-a3b8hyyr	1955	17	down	down	JJ
cord-006860-a3b8hyyr	1955	18	regulation	regulation	NN
cord-006860-a3b8hyyr	1955	19	of	of	IN
cord-006860-a3b8hyyr	1955	20	the	the	DT
cord-006860-a3b8hyyr	1955	21	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	1955	22	system	system	NN
cord-006860-a3b8hyyr	1955	23	,	,	,
cord-006860-a3b8hyyr	1955	24	increase	increase	NN
cord-006860-a3b8hyyr	1955	25	of	of	IN
cord-006860-a3b8hyyr	1955	26	erythrocyte	erythrocyte	NN
cord-006860-a3b8hyyr	1955	27	aggregation	aggregation	NN
cord-006860-a3b8hyyr	1955	28	and	and	CC
cord-006860-a3b8hyyr	1955	29	plasma	plasma	NN
cord-006860-a3b8hyyr	1955	30	viscosity	viscosity	NN
cord-006860-a3b8hyyr	1955	31	.	.	.
cord-006860-a3b8hyyr	1956	1	Also	also	RB
cord-006860-a3b8hyyr	1956	2	disturbances	disturbance	NNS
cord-006860-a3b8hyyr	1956	3	of	of	IN
cord-006860-a3b8hyyr	1956	4	lipid	lipid	NN
cord-006860-a3b8hyyr	1956	5	metabolism	metabolism	NN
cord-006860-a3b8hyyr	1957	1	an	an	DT
cord-006860-a3b8hyyr	1957	2	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	1957	3	WHR	WHR	NNP
cord-006860-a3b8hyyr	1957	4	seems	seem	VBZ
cord-006860-a3b8hyyr	1957	5	to	to	TO
cord-006860-a3b8hyyr	1957	6	be	be	VB
cord-006860-a3b8hyyr	1957	7	of	of	IN
cord-006860-a3b8hyyr	1957	8	an	an	DT
cord-006860-a3b8hyyr	1957	9	additional	additional	JJ
cord-006860-a3b8hyyr	1957	10	atherogenous	atherogenous	JJ
cord-006860-a3b8hyyr	1957	11	factor	factor	NN
cord-006860-a3b8hyyr	1957	12	in	in	IN
cord-006860-a3b8hyyr	1957	13	DM	DM	NNP
cord-006860-a3b8hyyr	1957	14	.	.	.
cord-006860-a3b8hyyr	1958	1	Plasma	plasma	NN
cord-006860-a3b8hyyr	1958	2	concentrations	concentration	NNS
cord-006860-a3b8hyyr	1958	3	of	of	IN
cord-006860-a3b8hyyr	1958	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1958	5	-	-	HYPH
cord-006860-a3b8hyyr	1958	6	anfithrombin	anfithrombin	NNP
cord-006860-a3b8hyyr	1958	7	-	-	HYPH
cord-006860-a3b8hyyr	1958	8	III	III	NNP
cord-006860-a3b8hyyr	1958	9	(	(	-LRB-
cord-006860-a3b8hyyr	1958	10	TAT	TAT	NNP
cord-006860-a3b8hyyr	1958	11	)	)	-RRB-
cord-006860-a3b8hyyr	1958	12	,	,	,
cord-006860-a3b8hyyr	1958	13	alpha-2antiplasmin	alpha-2antiplasmin	JJS
cord-006860-a3b8hyyr	1958	14	-	-	HYPH
cord-006860-a3b8hyyr	1958	15	plasmin	plasmin	JJ
cord-006860-a3b8hyyr	1958	16	(	(	-LRB-
cord-006860-a3b8hyyr	1958	17	APP	app	NN
cord-006860-a3b8hyyr	1958	18	)	)	-RRB-
cord-006860-a3b8hyyr	1958	19	complexes	complex	NNS
cord-006860-a3b8hyyr	1958	20	and	and	CC
cord-006860-a3b8hyyr	1958	21	DDimer	DDimer	NNP
cord-006860-a3b8hyyr	1958	22	were	be	VBD
cord-006860-a3b8hyyr	1958	23	investigated	investigate	VBN
cord-006860-a3b8hyyr	1958	24	in	in	IN
cord-006860-a3b8hyyr	1958	25	50	50	CD
cord-006860-a3b8hyyr	1958	26	patients	patient	NNS
cord-006860-a3b8hyyr	1958	27	treated	treat	VBN
cord-006860-a3b8hyyr	1958	28	with	with	IN
cord-006860-a3b8hyyr	1958	29	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	1958	30	therapy	therapy	NN
cord-006860-a3b8hyyr	1958	31	for	for	IN
cord-006860-a3b8hyyr	1958	32	acute	acute	JJ
cord-006860-a3b8hyyr	1958	33	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	1958	34	infarction	infarction	NN
cord-006860-a3b8hyyr	1958	35	(	(	-LRB-
cord-006860-a3b8hyyr	1958	36	AMI	AMI	NNP
cord-006860-a3b8hyyr	1958	37	)	)	-RRB-
cord-006860-a3b8hyyr	1958	38	either	either	CC
cord-006860-a3b8hyyr	1958	39	with	with	IN
cord-006860-a3b8hyyr	1958	40	streptokinase	streptokinase	NNP
cord-006860-a3b8hyyr	1958	41	(	(	-LRB-
cord-006860-a3b8hyyr	1958	42	n=24	n=24	NNP
cord-006860-a3b8hyyr	1958	43	)	)	-RRB-
cord-006860-a3b8hyyr	1958	44	,	,	,
cord-006860-a3b8hyyr	1958	45	urokinase	urokinase	NNP
cord-006860-a3b8hyyr	1958	46	(	(	-LRB-
cord-006860-a3b8hyyr	1958	47	n=16	n=16	NNP
cord-006860-a3b8hyyr	1958	48	)	)	-RRB-
cord-006860-a3b8hyyr	1958	49	or	or	CC
cord-006860-a3b8hyyr	1958	50	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	1958	51	t	t	NNP
cord-006860-a3b8hyyr	1958	52	-	-	HYPH
cord-006860-a3b8hyyr	1958	53	PA	PA	NNP
cord-006860-a3b8hyyr	1958	54	(	(	-LRB-
cord-006860-a3b8hyyr	1958	55	rt	rt	NNP
cord-006860-a3b8hyyr	1958	56	-	-	HYPH
cord-006860-a3b8hyyr	1958	57	PA	PA	NNP
cord-006860-a3b8hyyr	1958	58	,	,	,
cord-006860-a3b8hyyr	1958	59	n=10	n=10	NNP
cord-006860-a3b8hyyr	1958	60	)	)	-RRB-
cord-006860-a3b8hyyr	1958	61	.	.	.
cord-006860-a3b8hyyr	1959	1	All	all	DT
cord-006860-a3b8hyyr	1959	2	patients	patient	NNS
cord-006860-a3b8hyyr	1959	3	received	receive	VBD
cord-006860-a3b8hyyr	1959	4	an	an	DT
cord-006860-a3b8hyyr	1959	5	intravenous	intravenous	JJ
cord-006860-a3b8hyyr	1959	6	heparin	heparin	NN
cord-006860-a3b8hyyr	1959	7	bolus	bolus	NN
cord-006860-a3b8hyyr	1959	8	of	of	IN
cord-006860-a3b8hyyr	1959	9	5,000	5,000	CD
cord-006860-a3b8hyyr	1959	10	IU	IU	NNP
cord-006860-a3b8hyyr	1959	11	on	on	IN
cord-006860-a3b8hyyr	1959	12	admission	admission	NN
cord-006860-a3b8hyyr	1959	13	,	,	,
cord-006860-a3b8hyyr	1959	14	which	which	WDT
cord-006860-a3b8hyyr	1959	15	was	be	VBD
cord-006860-a3b8hyyr	1959	16	followed	follow	VBN
cord-006860-a3b8hyyr	1959	17	at	at	IN
cord-006860-a3b8hyyr	1959	18	once	once	RB
cord-006860-a3b8hyyr	1959	19	by	by	IN
cord-006860-a3b8hyyr	1959	20	an	an	DT
cord-006860-a3b8hyyr	1959	21	infusion	infusion	NN
cord-006860-a3b8hyyr	1959	22	of	of	IN
cord-006860-a3b8hyyr	1959	23	1,000	1,000	CD
cord-006860-a3b8hyyr	1959	24	IU	IU	NNP
cord-006860-a3b8hyyr	1959	25	/	/	SYM
cord-006860-a3b8hyyr	1959	26	hr	hr	NN
cord-006860-a3b8hyyr	1959	27	for	for	IN
cord-006860-a3b8hyyr	1959	28	the	the	DT
cord-006860-a3b8hyyr	1959	29	next	next	JJ
cord-006860-a3b8hyyr	1959	30	three	three	CD
cord-006860-a3b8hyyr	1959	31	days	day	NNS
cord-006860-a3b8hyyr	1959	32	titrated	titrate	VBN
cord-006860-a3b8hyyr	1959	33	to	to	TO
cord-006860-a3b8hyyr	1959	34	maintain	maintain	VB
cord-006860-a3b8hyyr	1959	35	the	the	DT
cord-006860-a3b8hyyr	1959	36	partial	partial	JJ
cord-006860-a3b8hyyr	1959	37	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	1959	38	time	time	NN
cord-006860-a3b8hyyr	1959	39	at	at	IN
cord-006860-a3b8hyyr	1959	40	twice	twice	JJ
cord-006860-a3b8hyyr	1959	41	control	control	NN
cord-006860-a3b8hyyr	1959	42	value	value	NN
cord-006860-a3b8hyyr	1959	43	.	.	.
cord-006860-a3b8hyyr	1960	1	TAT	tat	NN
cord-006860-a3b8hyyr	1960	2	,	,	,
cord-006860-a3b8hyyr	1960	3	PAP	pap	NN
cord-006860-a3b8hyyr	1960	4	and	and	CC
cord-006860-a3b8hyyr	1960	5	DDimer	DDimer	NNP
cord-006860-a3b8hyyr	1960	6	were	be	VBD
cord-006860-a3b8hyyr	1960	7	measured	measure	VBN
cord-006860-a3b8hyyr	1960	8	by	by	IN
cord-006860-a3b8hyyr	1960	9	enzyme	enzyme	NN
cord-006860-a3b8hyyr	1960	10	immunoassay	immunoassay	NN
cord-006860-a3b8hyyr	1960	11	on	on	IN
cord-006860-a3b8hyyr	1960	12	admission	admission	NN
cord-006860-a3b8hyyr	1960	13	,	,	,
cord-006860-a3b8hyyr	1960	14	1	1	CD
cord-006860-a3b8hyyr	1960	15	,	,	,
cord-006860-a3b8hyyr	1960	16	2	2	CD
cord-006860-a3b8hyyr	1960	17	,	,	,
cord-006860-a3b8hyyr	1960	18	4	4	CD
cord-006860-a3b8hyyr	1960	19	,	,	,
cord-006860-a3b8hyyr	1960	20	6	6	CD
cord-006860-a3b8hyyr	1960	21	,	,	,
cord-006860-a3b8hyyr	1960	22	8	8	CD
cord-006860-a3b8hyyr	1960	23	,	,	,
cord-006860-a3b8hyyr	1960	24	12	12	CD
cord-006860-a3b8hyyr	1960	25	,	,	,
cord-006860-a3b8hyyr	1960	26	24	24	CD
cord-006860-a3b8hyyr	1960	27	hours	hour	NNS
cord-006860-a3b8hyyr	1960	28	and	and	CC
cord-006860-a3b8hyyr	1960	29	on	on	IN
cord-006860-a3b8hyyr	1960	30	day	day	NN
cord-006860-a3b8hyyr	1960	31	3	3	CD
cord-006860-a3b8hyyr	1960	32	and	and	CC
cord-006860-a3b8hyyr	1960	33	7	7	CD
cord-006860-a3b8hyyr	1960	34	after	after	IN
cord-006860-a3b8hyyr	1960	35	admission	admission	NN
cord-006860-a3b8hyyr	1960	36	.	.	.
cord-006860-a3b8hyyr	1961	1	Groups	group	NNS
cord-006860-a3b8hyyr	1961	2	did	do	VBD
cord-006860-a3b8hyyr	1961	3	not	not	RB
cord-006860-a3b8hyyr	1961	4	differ	differ	VB
cord-006860-a3b8hyyr	1961	5	significantly	significantly	RB
cord-006860-a3b8hyyr	1961	6	in	in	IN
cord-006860-a3b8hyyr	1961	7	regard	regard	NN
cord-006860-a3b8hyyr	1961	8	to	to	IN
cord-006860-a3b8hyyr	1961	9	age	age	NN
cord-006860-a3b8hyyr	1961	10	,	,	,
cord-006860-a3b8hyyr	1961	11	sex	sex	NN
cord-006860-a3b8hyyr	1961	12	,	,	,
cord-006860-a3b8hyyr	1961	13	delay	delay	NN
cord-006860-a3b8hyyr	1961	14	and	and	CC
cord-006860-a3b8hyyr	1961	15	infarct	infarct	NN
cord-006860-a3b8hyyr	1961	16	location	location	NN
cord-006860-a3b8hyyr	1961	17	.	.	.
cord-006860-a3b8hyyr	1962	1	On	on	IN
cord-006860-a3b8hyyr	1962	2	admission	admission	NN
cord-006860-a3b8hyyr	1962	3	,	,	,
cord-006860-a3b8hyyr	1962	4	no	no	DT
cord-006860-a3b8hyyr	1962	5	marker	marker	NN
cord-006860-a3b8hyyr	1962	6	differed	differ	VBD
cord-006860-a3b8hyyr	1962	7	significantly	significantly	RB
cord-006860-a3b8hyyr	1962	8	between	between	IN
cord-006860-a3b8hyyr	1962	9	groups	group	NNS
cord-006860-a3b8hyyr	1962	10	.	.	.
cord-006860-a3b8hyyr	1963	1	Thereafter	thereafter	RB
cord-006860-a3b8hyyr	1963	2	,	,	,
cord-006860-a3b8hyyr	1963	3	TAT	tat	NN
cord-006860-a3b8hyyr	1963	4	levels	level	NNS
cord-006860-a3b8hyyr	1963	5	increased	increase	VBD
cord-006860-a3b8hyyr	1963	6	significantly	significantly	RB
cord-006860-a3b8hyyr	1963	7	exclusively	exclusively	RB
cord-006860-a3b8hyyr	1963	8	in	in	IN
cord-006860-a3b8hyyr	1963	9	rtPA	rtPA	NNP
cord-006860-a3b8hyyr	1963	10	treated	treat	VBN
cord-006860-a3b8hyyr	1963	11	group	group	NN
cord-006860-a3b8hyyr	1963	12	.	.	.
cord-006860-a3b8hyyr	1964	1	From	from	IN
cord-006860-a3b8hyyr	1964	2	2	2	CD
cord-006860-a3b8hyyr	1964	3	to	to	TO
cord-006860-a3b8hyyr	1964	4	6	6	CD
cord-006860-a3b8hyyr	1964	5	hours	hour	NNS
cord-006860-a3b8hyyr	1964	6	after	after	IN
cord-006860-a3b8hyyr	1964	7	admission	admission	NN
cord-006860-a3b8hyyr	1964	8	,	,	,
cord-006860-a3b8hyyr	1964	9	TAT	TAT	NNP
cord-006860-a3b8hyyr	1964	10	were	be	VBD
cord-006860-a3b8hyyr	1964	11	significantly	significantly	RB
cord-006860-a3b8hyyr	1964	12	higher	high	JJR
cord-006860-a3b8hyyr	1964	13	in	in	IN
cord-006860-a3b8hyyr	1964	14	rtPA	rtPA	NNP
cord-006860-a3b8hyyr	1964	15	treated	treat	VBD
cord-006860-a3b8hyyr	1964	16	patients	patient	NNS
cord-006860-a3b8hyyr	1964	17	than	than	IN
cord-006860-a3b8hyyr	1964	18	in	in	IN
cord-006860-a3b8hyyr	1964	19	streptokinase	streptokinase	NNP
cord-006860-a3b8hyyr	1964	20	and	and	CC
cord-006860-a3b8hyyr	1964	21	urokinase	urokinase	NNP
cord-006860-a3b8hyyr	1964	22	treated	treat	VBD
cord-006860-a3b8hyyr	1964	23	group	group	NN
cord-006860-a3b8hyyr	1964	24	(	(	-LRB-
cord-006860-a3b8hyyr	1964	25	p<0.02	p<0.02	NN
cord-006860-a3b8hyyr	1964	26	)	)	-RRB-
cord-006860-a3b8hyyr	1964	27	.	.	.
cord-006860-a3b8hyyr	1965	1	However	however	RB
cord-006860-a3b8hyyr	1965	2	,	,	,
cord-006860-a3b8hyyr	1965	3	during	during	IN
cord-006860-a3b8hyyr	1965	4	continous	continous	JJ
cord-006860-a3b8hyyr	1965	5	heparin	heparin	NN
cord-006860-a3b8hyyr	1965	6	infusion	infusion	NN
cord-006860-a3b8hyyr	1965	7	,	,	,
cord-006860-a3b8hyyr	1965	8	which	which	WDT
cord-006860-a3b8hyyr	1965	9	was	be	VBD
cord-006860-a3b8hyyr	1965	10	started	start	VBN
cord-006860-a3b8hyyr	1965	11	immediately	immediately	RB
cord-006860-a3b8hyyr	1965	12	after	after	IN
cord-006860-a3b8hyyr	1965	13	stop	stop	NN
cord-006860-a3b8hyyr	1965	14	of	of	IN
cord-006860-a3b8hyyr	1965	15	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	1965	16	therapy	therapy	NN
cord-006860-a3b8hyyr	1965	17	,	,	,
cord-006860-a3b8hyyr	1965	18	in	in	IN
cord-006860-a3b8hyyr	1965	19	each	each	DT
cord-006860-a3b8hyyr	1965	20	group	group	NN
cord-006860-a3b8hyyr	1965	21	TAT	tat	NN
cord-006860-a3b8hyyr	1965	22	concentrations	concentration	NNS
cord-006860-a3b8hyyr	1965	23	decreased	decrease	VBD
cord-006860-a3b8hyyr	1965	24	below	below	IN
cord-006860-a3b8hyyr	1965	25	admission	admission	NN
cord-006860-a3b8hyyr	1965	26	values	value	NNS
cord-006860-a3b8hyyr	1965	27	.	.	.
cord-006860-a3b8hyyr	1966	1	APP	APP	NNP
cord-006860-a3b8hyyr	1966	2	were	be	VBD
cord-006860-a3b8hyyr	1966	3	significantly	significantly	RB
cord-006860-a3b8hyyr	1966	4	higher	high	JJR
cord-006860-a3b8hyyr	1966	5	only	only	RB
cord-006860-a3b8hyyr	1966	6	1	1	CD
cord-006860-a3b8hyyr	1966	7	hour	hour	NN
cord-006860-a3b8hyyr	1966	8	after	after	IN
cord-006860-a3b8hyyr	1966	9	admission	admission	NN
cord-006860-a3b8hyyr	1966	10	in	in	IN
cord-006860-a3b8hyyr	1966	11	the	the	DT
cord-006860-a3b8hyyr	1966	12	rt	rt	NNP
cord-006860-a3b8hyyr	1966	13	-	-	HYPH
cord-006860-a3b8hyyr	1966	14	PA	PA	NNP
cord-006860-a3b8hyyr	1966	15	group	group	NN
cord-006860-a3b8hyyr	1966	16	(	(	-LRB-
cord-006860-a3b8hyyr	1966	17	p=0.03	p=0.03	NN
cord-006860-a3b8hyyr	1966	18	)	)	-RRB-
cord-006860-a3b8hyyr	1966	19	.	.	.
cord-006860-a3b8hyyr	1967	1	DDimer	DDimer	NNP
cord-006860-a3b8hyyr	1967	2	did	do	VBD
cord-006860-a3b8hyyr	1967	3	not	not	RB
cord-006860-a3b8hyyr	1967	4	differ	differ	VB
cord-006860-a3b8hyyr	1967	5	signifieanfly	signifieanfly	NN
cord-006860-a3b8hyyr	1967	6	between	between	IN
cord-006860-a3b8hyyr	1967	7	groups	group	NNS
cord-006860-a3b8hyyr	1967	8	.	.	.
cord-006860-a3b8hyyr	1968	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	1968	2	results	result	NNS
cord-006860-a3b8hyyr	1968	3	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	1968	4	,	,	,
cord-006860-a3b8hyyr	1968	5	that	that	IN
cord-006860-a3b8hyyr	1968	6	rtPA	rtPA	NNP
cord-006860-a3b8hyyr	1968	7	induces	induce	VBZ
cord-006860-a3b8hyyr	1968	8	a	a	DT
cord-006860-a3b8hyyr	1968	9	hypercoagulable	hypercoagulable	JJ
cord-006860-a3b8hyyr	1968	10	state	state	NN
cord-006860-a3b8hyyr	1968	11	,	,	,
cord-006860-a3b8hyyr	1968	12	which	which	WDT
cord-006860-a3b8hyyr	1968	13	may	may	MD
cord-006860-a3b8hyyr	1968	14	contribute	contribute	VB
cord-006860-a3b8hyyr	1968	15	to	to	IN
cord-006860-a3b8hyyr	1968	16	reocclusion	reocclusion	NN
cord-006860-a3b8hyyr	1968	17	after	after	IN
cord-006860-a3b8hyyr	1968	18	successful	successful	JJ
cord-006860-a3b8hyyr	1968	19	reopening	reopening	NN
cord-006860-a3b8hyyr	1968	20	of	of	IN
cord-006860-a3b8hyyr	1968	21	the	the	DT
cord-006860-a3b8hyyr	1968	22	infarctrelated	infarctrelate	VBN
cord-006860-a3b8hyyr	1968	23	coronary	coronary	JJ
cord-006860-a3b8hyyr	1968	24	artery	artery	NN
cord-006860-a3b8hyyr	1968	25	.	.	.
cord-006860-a3b8hyyr	1969	1	The	the	DT
cord-006860-a3b8hyyr	1969	2	significant	significant	JJ
cord-006860-a3b8hyyr	1969	3	TAT	tat	NN
cord-006860-a3b8hyyr	1969	4	decrease	decrease	NN
cord-006860-a3b8hyyr	1969	5	during	during	IN
cord-006860-a3b8hyyr	1969	6	continous	continous	JJ
cord-006860-a3b8hyyr	1969	7	heparin	heparin	NN
cord-006860-a3b8hyyr	1969	8	infusion	infusion	NN
cord-006860-a3b8hyyr	1969	9	supports	support	VBZ
cord-006860-a3b8hyyr	1969	10	the	the	DT
cord-006860-a3b8hyyr	1969	11	concomitant	concomitant	JJ
cord-006860-a3b8hyyr	1969	12	use	use	NN
cord-006860-a3b8hyyr	1969	13	of	of	IN
cord-006860-a3b8hyyr	1969	14	thrombin	thrombin	NN
cord-006860-a3b8hyyr	1969	15	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1969	16	as	as	IN
cord-006860-a3b8hyyr	1969	17	adjunctive	adjunctive	JJ
cord-006860-a3b8hyyr	1969	18	therapy	therapy	NN
cord-006860-a3b8hyyr	1969	19	with	with	IN
cord-006860-a3b8hyyr	1969	20	thrombolytlc	thrombolytlc	NNP
cord-006860-a3b8hyyr	1969	21	treatment	treatment	NN
cord-006860-a3b8hyyr	1969	22	for	for	IN
cord-006860-a3b8hyyr	1969	23	AMI	AMI	NNP
cord-006860-a3b8hyyr	1969	24	.	.	.
cord-006860-a3b8hyyr	1970	1	Thus	thus	RB
cord-006860-a3b8hyyr	1970	2	,	,	,
cord-006860-a3b8hyyr	1970	3	in	in	IN
cord-006860-a3b8hyyr	1970	4	acute	acute	JJ
cord-006860-a3b8hyyr	1970	5	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	1970	6	infarction	infarction	NN
cord-006860-a3b8hyyr	1970	7	patients	patient	NNS
cord-006860-a3b8hyyr	1970	8	,	,	,
cord-006860-a3b8hyyr	1970	9	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	1970	10	generation	generation	NN
cord-006860-a3b8hyyr	1970	11	is	be	VBZ
cord-006860-a3b8hyyr	1970	12	markedly	markedly	RB
cord-006860-a3b8hyyr	1970	13	influenced	influence	VBN
cord-006860-a3b8hyyr	1970	14	by	by	IN
cord-006860-a3b8hyyr	1970	15	the	the	DT
cord-006860-a3b8hyyr	1970	16	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	1970	17	agent	agent	NN
cord-006860-a3b8hyyr	1970	18	used	use	VBD
cord-006860-a3b8hyyr	1970	19	and	and	CC
cord-006860-a3b8hyyr	1970	20	concomitant	concomitant	JJ
cord-006860-a3b8hyyr	1970	21	heparin	heparin	NN
cord-006860-a3b8hyyr	1970	22	therapy	therapy	NN
cord-006860-a3b8hyyr	1970	23	.	.	.
cord-006860-a3b8hyyr	1971	1	Endothelium	endothelium	NN
cord-006860-a3b8hyyr	1971	2	derived	derive	VBD
cord-006860-a3b8hyyr	1971	3	relaxing	relax	VBG
cord-006860-a3b8hyyr	1971	4	factor	factor	NN
cord-006860-a3b8hyyr	1972	1	-NO	-no	RB
cord-006860-a3b8hyyr	1973	1	(	(	-LRB-
cord-006860-a3b8hyyr	1973	2	EDRF	EDRF	NNP
cord-006860-a3b8hyyr	1973	3	-	-	HYPH
cord-006860-a3b8hyyr	1973	4	NO	no	NN
cord-006860-a3b8hyyr	1973	5	)	)	-RRB-
cord-006860-a3b8hyyr	1973	6	plays	play	VBZ
cord-006860-a3b8hyyr	1973	7	a	a	DT
cord-006860-a3b8hyyr	1973	8	major	major	JJ
cord-006860-a3b8hyyr	1973	9	role	role	NN
cord-006860-a3b8hyyr	1973	10	in	in	IN
cord-006860-a3b8hyyr	1973	11	regulation	regulation	NN
cord-006860-a3b8hyyr	1973	12	of	of	IN
cord-006860-a3b8hyyr	1973	13	vascular	vascular	JJ
cord-006860-a3b8hyyr	1973	14	tonicity	tonicity	NN
cord-006860-a3b8hyyr	1973	15	and	and	CC
cord-006860-a3b8hyyr	1973	16	also	also	RB
cord-006860-a3b8hyyr	1973	17	exerts	exert	VBZ
cord-006860-a3b8hyyr	1973	18	platelet	platelet	NN
cord-006860-a3b8hyyr	1973	19	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	1973	20	action~	action~	RB
cord-006860-a3b8hyyr	1974	1	However	however	RB
cord-006860-a3b8hyyr	1974	2	,	,	,
cord-006860-a3b8hyyr	1974	3	due	due	IN
cord-006860-a3b8hyyr	1974	4	to	to	IN
cord-006860-a3b8hyyr	1974	5	the	the	DT
cord-006860-a3b8hyyr	1974	6	chemical	chemical	JJ
cord-006860-a3b8hyyr	1974	7	nature	nature	NN
cord-006860-a3b8hyyr	1974	8	of	of	IN
cord-006860-a3b8hyyr	1974	9	EDRF	EDRF	NNP
cord-006860-a3b8hyyr	1974	10	-	-	HYPH
cord-006860-a3b8hyyr	1974	11	NO	no	DT
cord-006860-a3b8hyyr	1974	12	few	few	JJ
cord-006860-a3b8hyyr	1974	13	is	be	VBZ
cord-006860-a3b8hyyr	1974	14	known	know	VBN
cord-006860-a3b8hyyr	1974	15	about	about	IN
cord-006860-a3b8hyyr	1974	16	its	-PRON-	PRP$
cord-006860-a3b8hyyr	1974	17	production	production	NN
cord-006860-a3b8hyyr	1974	18	and	and	CC
cord-006860-a3b8hyyr	1974	19	activity	activity	NN
cord-006860-a3b8hyyr	1974	20	as	as	IN
cord-006860-a3b8hyyr	1974	21	a	a	DT
cord-006860-a3b8hyyr	1974	22	general	general	JJ
cord-006860-a3b8hyyr	1974	23	index	index	NN
cord-006860-a3b8hyyr	1974	24	or	or	CC
cord-006860-a3b8hyyr	1974	25	marker	marker	NN
cord-006860-a3b8hyyr	1974	26	of	of	IN
cord-006860-a3b8hyyr	1974	27	vascular	vascular	JJ
cord-006860-a3b8hyyr	1974	28	function	function	NN
cord-006860-a3b8hyyr	1974	29	in	in	IN
cord-006860-a3b8hyyr	1974	30	human	human	JJ
cord-006860-a3b8hyyr	1974	31	diseases	disease	NNS
cord-006860-a3b8hyyr	1974	32	.	.	.
cord-006860-a3b8hyyr	1975	1	One	one	CD
cord-006860-a3b8hyyr	1975	2	way	way	NN
cord-006860-a3b8hyyr	1975	3	to	to	TO
cord-006860-a3b8hyyr	1975	4	achieve	achieve	VB
cord-006860-a3b8hyyr	1975	5	this	this	DT
cord-006860-a3b8hyyr	1975	6	can	can	MD
cord-006860-a3b8hyyr	1975	7	be	be	VB
cord-006860-a3b8hyyr	1975	8	measurement	measurement	NN
cord-006860-a3b8hyyr	1975	9	of	of	IN
cord-006860-a3b8hyyr	1975	10	nitrate	nitrate	NN
cord-006860-a3b8hyyr	1975	11	/	/	SYM
cord-006860-a3b8hyyr	1975	12	nitrite	nitrite	NN
cord-006860-a3b8hyyr	1975	13	excretion	excretion	NN
cord-006860-a3b8hyyr	1975	14	in	in	IN
cord-006860-a3b8hyyr	1975	15	the	the	DT
cord-006860-a3b8hyyr	1975	16	urine	urine	NN
cord-006860-a3b8hyyr	1975	17	,	,	,
cord-006860-a3b8hyyr	1975	18	which	which	WDT
cord-006860-a3b8hyyr	1975	19	seems	seem	VBZ
cord-006860-a3b8hyyr	1975	20	to	to	TO
cord-006860-a3b8hyyr	1975	21	reflect	reflect	VB
cord-006860-a3b8hyyr	1975	22	vascular	vascular	JJ
cord-006860-a3b8hyyr	1975	23	EDRF	edrf	JJ
cord-006860-a3b8hyyr	1975	24	-	-	HYPH
cord-006860-a3b8hyyr	1975	25	NO	no	DT
cord-006860-a3b8hyyr	1975	26	production	production	NN
cord-006860-a3b8hyyr	1975	27	.	.	.
cord-006860-a3b8hyyr	1976	1	In	in	IN
cord-006860-a3b8hyyr	1976	2	this	this	DT
cord-006860-a3b8hyyr	1976	3	report	report	NN
cord-006860-a3b8hyyr	1976	4	a	a	DT
cord-006860-a3b8hyyr	1976	5	self	self	NN
cord-006860-a3b8hyyr	1976	6	-	-	HYPH
cord-006860-a3b8hyyr	1976	7	developed	develop	VBN
cord-006860-a3b8hyyr	1976	8	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	1976	9	method	method	NN
cord-006860-a3b8hyyr	1976	10	is	be	VBZ
cord-006860-a3b8hyyr	1976	11	described	describe	VBN
cord-006860-a3b8hyyr	1976	12	,	,	,
cord-006860-a3b8hyyr	1976	13	which	which	WDT
cord-006860-a3b8hyyr	1976	14	was	be	VBD
cord-006860-a3b8hyyr	1976	15	used	use	VBN
cord-006860-a3b8hyyr	1976	16	for	for	IN
cord-006860-a3b8hyyr	1976	17	this	this	DT
cord-006860-a3b8hyyr	1976	18	perpose	perpose	NN
cord-006860-a3b8hyyr	1976	19	.	.	.
cord-006860-a3b8hyyr	1977	1	Nitrate	nitrate	NN
cord-006860-a3b8hyyr	1977	2	/	/	SYM
cord-006860-a3b8hyyr	1977	3	nitrite	nitrite	NN
cord-006860-a3b8hyyr	1977	4	urinary	urinary	JJ
cord-006860-a3b8hyyr	1977	5	exretion	exretion	NN
cord-006860-a3b8hyyr	1977	6	proved	prove	VBD
cord-006860-a3b8hyyr	1977	7	to	to	IN
cord-006860-a3b8hyyr	1977	8	significantly	significantly	RB
cord-006860-a3b8hyyr	1977	9	decreased	decrease	VBD
cord-006860-a3b8hyyr	1977	10	in	in	IN
cord-006860-a3b8hyyr	1977	11	insulin	insulin	NN
cord-006860-a3b8hyyr	1977	12	dependent	dependent	JJ
cord-006860-a3b8hyyr	1977	13	and	and	CC
cord-006860-a3b8hyyr	1977	14	in	in	IN
cord-006860-a3b8hyyr	1977	15	non	non	JJ
cord-006860-a3b8hyyr	1977	16	-	-	JJ
cord-006860-a3b8hyyr	1977	17	insulin	insulin	JJ
cord-006860-a3b8hyyr	1977	18	dependent	dependent	JJ
cord-006860-a3b8hyyr	1977	19	diabetes	diabetes	NN
cord-006860-a3b8hyyr	1977	20	mellitus	mellitus	NN
cord-006860-a3b8hyyr	1977	21	as	as	RB
cord-006860-a3b8hyyr	1977	22	well	well	RB
cord-006860-a3b8hyyr	1977	23	After	after	IN
cord-006860-a3b8hyyr	1977	24	a	a	DT
cord-006860-a3b8hyyr	1977	25	comparison	comparison	NN
cord-006860-a3b8hyyr	1977	26	of	of	IN
cord-006860-a3b8hyyr	1977	27	the	the	DT
cord-006860-a3b8hyyr	1977	28	excretion	excretion	NN
cord-006860-a3b8hyyr	1977	29	values	value	NNS
cord-006860-a3b8hyyr	1977	30	to	to	IN
cord-006860-a3b8hyyr	1977	31	other	other	JJ
cord-006860-a3b8hyyr	1977	32	markers	marker	NNS
cord-006860-a3b8hyyr	1977	33	of	of	IN
cord-006860-a3b8hyyr	1977	34	angiopathy	angiopathy	NNP
cord-006860-a3b8hyyr	1977	35	(	(	-LRB-
cord-006860-a3b8hyyr	1977	36	yon	yon	NNP
cord-006860-a3b8hyyr	1977	37	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	1977	38	factoD	factoD	NNP
cord-006860-a3b8hyyr	1977	39	soluble	soluble	JJ
cord-006860-a3b8hyyr	1977	40	thrombomodulin	thrombomodulin	NN
cord-006860-a3b8hyyr	1977	41	,	,	,
cord-006860-a3b8hyyr	1977	42	beta	beta	NN
cord-006860-a3b8hyyr	1977	43	-thromboglobulin	-thromboglobulin	CD
cord-006860-a3b8hyyr	1977	44	)	)	-RRB-
cord-006860-a3b8hyyr	1978	1	it	-PRON-	PRP
cord-006860-a3b8hyyr	1978	2	seems	seem	VBZ
cord-006860-a3b8hyyr	1978	3	to	to	TO
cord-006860-a3b8hyyr	1978	4	be	be	VB
cord-006860-a3b8hyyr	1978	5	acceptable	acceptable	JJ
cord-006860-a3b8hyyr	1978	6	,	,	,
cord-006860-a3b8hyyr	1978	7	that	that	IN
cord-006860-a3b8hyyr	1978	8	urinary	urinary	JJ
cord-006860-a3b8hyyr	1978	9	nitrate	nitrate	NN
cord-006860-a3b8hyyr	1978	10	/	/	SYM
cord-006860-a3b8hyyr	1978	11	nitrite	nitrite	NN
cord-006860-a3b8hyyr	1978	12	excretion	excretion	NN
cord-006860-a3b8hyyr	1978	13	can	can	MD
cord-006860-a3b8hyyr	1978	14	be	be	VB
cord-006860-a3b8hyyr	1978	15	a	a	DT
cord-006860-a3b8hyyr	1978	16	useful	useful	JJ
cord-006860-a3b8hyyr	1978	17	indicate	indicate	NN
cord-006860-a3b8hyyr	1978	18	of	of	IN
cord-006860-a3b8hyyr	1978	19	diabetic	diabetic	JJ
cord-006860-a3b8hyyr	1978	20	vascular	vascular	JJ
cord-006860-a3b8hyyr	1978	21	disorders	disorder	NNS
cord-006860-a3b8hyyr	1978	22	.	.	.
cord-006860-a3b8hyyr	1979	1	Two	two	CD
cord-006860-a3b8hyyr	1979	2	major	major	JJ
cord-006860-a3b8hyyr	1979	3	concerns	concern	NNS
cord-006860-a3b8hyyr	1979	4	still	still	RB
cord-006860-a3b8hyyr	1979	5	accompany	accompany	VBP
cord-006860-a3b8hyyr	1979	6	the	the	DT
cord-006860-a3b8hyyr	1979	7	application	application	NN
cord-006860-a3b8hyyr	1979	8	of	of	IN
cord-006860-a3b8hyyr	1979	9	Prothrombin	Prothrombin	NNP
cord-006860-a3b8hyyr	1979	10	Complex	Complex	NNP
cord-006860-a3b8hyyr	1979	11	Concentrates	Concentrates	NNPS
cord-006860-a3b8hyyr	1979	12	(	(	-LRB-
cord-006860-a3b8hyyr	1979	13	PCC	PCC	NNP
cord-006860-a3b8hyyr	1979	14	)	)	-RRB-
cord-006860-a3b8hyyr	1979	15	.	.	.
cord-006860-a3b8hyyr	1980	1	Viral	viral	JJ
cord-006860-a3b8hyyr	1980	2	safety	safety	NN
cord-006860-a3b8hyyr	1980	3	has	have	VBZ
cord-006860-a3b8hyyr	1980	4	to	to	TO
cord-006860-a3b8hyyr	1980	5	be	be	VB
cord-006860-a3b8hyyr	1980	6	guaranteed	guarantee	VBN
cord-006860-a3b8hyyr	1980	7	and	and	CC
cord-006860-a3b8hyyr	1980	8	therefore	therefore	RB
cord-006860-a3b8hyyr	1980	9	several	several	JJ
cord-006860-a3b8hyyr	1980	10	measures	measure	NNS
cord-006860-a3b8hyyr	1980	11	for	for	IN
cord-006860-a3b8hyyr	1980	12	virus	virus	NN
cord-006860-a3b8hyyr	1980	13	inactivation	inactivation	NN
cord-006860-a3b8hyyr	1980	14	or	or	CC
cord-006860-a3b8hyyr	1980	15	elimination	elimination	NN
cord-006860-a3b8hyyr	1980	16	are	be	VBP
cord-006860-a3b8hyyr	1980	17	taken	take	VBN
cord-006860-a3b8hyyr	1980	18	during	during	IN
cord-006860-a3b8hyyr	1980	19	the	the	DT
cord-006860-a3b8hyyr	1980	20	manufacturing	manufacturing	NN
cord-006860-a3b8hyyr	1980	21	process	process	NN
cord-006860-a3b8hyyr	1980	22	.	.	.
cord-006860-a3b8hyyr	1981	1	The	the	DT
cord-006860-a3b8hyyr	1981	2	inherent	inherent	JJ
cord-006860-a3b8hyyr	1981	3	risk	risk	NN
cord-006860-a3b8hyyr	1981	4	of	of	IN
cord-006860-a3b8hyyr	1981	5	thrombo	thrombo	NNP
cord-006860-a3b8hyyr	1981	6	-	-	HYPH
cord-006860-a3b8hyyr	1981	7	embolic	embolic	JJ
cord-006860-a3b8hyyr	1981	8	side	side	NN
cord-006860-a3b8hyyr	1981	9	effects	effect	NNS
cord-006860-a3b8hyyr	1981	10	has	have	VBZ
cord-006860-a3b8hyyr	1981	11	to	to	TO
cord-006860-a3b8hyyr	1981	12	be	be	VB
cord-006860-a3b8hyyr	1981	13	considered	consider	VBN
cord-006860-a3b8hyyr	1981	14	.	.	.
cord-006860-a3b8hyyr	1982	1	To	to	TO
cord-006860-a3b8hyyr	1982	2	minimize	minimize	VB
cord-006860-a3b8hyyr	1982	3	these	these	DT
cord-006860-a3b8hyyr	1982	4	risks	risk	NNS
cord-006860-a3b8hyyr	1982	5	and	and	CC
cord-006860-a3b8hyyr	1982	6	to	to	TO
cord-006860-a3b8hyyr	1982	7	achieve	achieve	VB
cord-006860-a3b8hyyr	1982	8	good	good	JJ
cord-006860-a3b8hyyr	1982	9	clinical	clinical	JJ
cord-006860-a3b8hyyr	1982	10	efficiency	efficiency	NN
cord-006860-a3b8hyyr	1982	11	the	the	DT
cord-006860-a3b8hyyr	1982	12	quality	quality	NN
cord-006860-a3b8hyyr	1982	13	criteria	criterion	NNS
cord-006860-a3b8hyyr	1982	14	for	for	IN
cord-006860-a3b8hyyr	1982	15	PCC	PCC	NNP
cord-006860-a3b8hyyr	1982	16	's	's	POS
cord-006860-a3b8hyyr	1982	17	are	be	VBP
cord-006860-a3b8hyyr	1982	18	under	under	IN
cord-006860-a3b8hyyr	1982	19	pending	pende	VBG
cord-006860-a3b8hyyr	1982	20	discussion	discussion	NN
cord-006860-a3b8hyyr	1982	21	.	.	.
cord-006860-a3b8hyyr	1983	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1983	2	is	be	VBZ
cord-006860-a3b8hyyr	1983	3	generally	generally	RB
cord-006860-a3b8hyyr	1983	4	accepted	accept	VBN
cord-006860-a3b8hyyr	1983	5	that	that	IN
cord-006860-a3b8hyyr	1983	6	a	a	DT
cord-006860-a3b8hyyr	1983	7	modem	modem	NN
cord-006860-a3b8hyyr	1983	8	PCC	PCC	NNP
cord-006860-a3b8hyyr	1983	9	-	-	HYPH
cord-006860-a3b8hyyr	1983	10	preparation	preparation	NN
cord-006860-a3b8hyyr	1983	11	should	should	MD
cord-006860-a3b8hyyr	1983	12	contain	contain	VB
cord-006860-a3b8hyyr	1983	13	all	all	DT
cord-006860-a3b8hyyr	1983	14	of	of	IN
cord-006860-a3b8hyyr	1983	15	the	the	DT
cord-006860-a3b8hyyr	1983	16	four	four	CD
cord-006860-a3b8hyyr	1983	17	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1983	18	factors	factor	NNS
cord-006860-a3b8hyyr	1983	19	in	in	IN
cord-006860-a3b8hyyr	1983	20	a	a	DT
cord-006860-a3b8hyyr	1983	21	well	well	RB
cord-006860-a3b8hyyr	1983	22	balanced	balanced	JJ
cord-006860-a3b8hyyr	1983	23	proportion	proportion	NN
cord-006860-a3b8hyyr	1983	24	and	and	CC
cord-006860-a3b8hyyr	1983	25	that	that	IN
cord-006860-a3b8hyyr	1983	26	it	-PRON-	PRP
cord-006860-a3b8hyyr	1983	27	should	should	MD
cord-006860-a3b8hyyr	1983	28	also	also	RB
cord-006860-a3b8hyyr	1983	29	contain	contain	VB
cord-006860-a3b8hyyr	1983	30	protein	protein	NN
cord-006860-a3b8hyyr	1983	31	C	c	NN
cord-006860-a3b8hyyr	1983	32	and	and	CC
cord-006860-a3b8hyyr	1983	33	protein	protein	NN
cord-006860-a3b8hyyr	1983	34	S.	S.	NNP
cord-006860-a3b8hyyr	1983	35	Additionally	additionally	RB
cord-006860-a3b8hyyr	1983	36	,	,	,
cord-006860-a3b8hyyr	1983	37	the	the	DT
cord-006860-a3b8hyyr	1983	38	concentration	concentration	NN
cord-006860-a3b8hyyr	1983	39	of	of	IN
cord-006860-a3b8hyyr	1983	40	activated	activate	VBN
cord-006860-a3b8hyyr	1983	41	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1983	42	factors	factor	NNS
cord-006860-a3b8hyyr	1983	43	should	should	MD
cord-006860-a3b8hyyr	1983	44	be	be	VB
cord-006860-a3b8hyyr	1983	45	kept	keep	VBN
cord-006860-a3b8hyyr	1983	46	at	at	IN
cord-006860-a3b8hyyr	1983	47	a	a	DT
cord-006860-a3b8hyyr	1983	48	minimum	minimum	NN
cord-006860-a3b8hyyr	1983	49	.	.	.
cord-006860-a3b8hyyr	1984	1	A	a	DT
cord-006860-a3b8hyyr	1984	2	present	present	JJ
cord-006860-a3b8hyyr	1984	3	PCC	PCC	NNP
cord-006860-a3b8hyyr	1984	4	-	-	HYPH
cord-006860-a3b8hyyr	1984	5	produedon	produedon	NN
cord-006860-a3b8hyyr	1984	6	process	process	NN
cord-006860-a3b8hyyr	1984	7	mainly	mainly	RB
cord-006860-a3b8hyyr	1984	8	consists	consist	VBZ
cord-006860-a3b8hyyr	1984	9	of	of	IN
cord-006860-a3b8hyyr	1984	10	a	a	DT
cord-006860-a3b8hyyr	1984	11	QAE	QAE	NNP
cord-006860-a3b8hyyr	1984	12	-	-	HYPH
cord-006860-a3b8hyyr	1984	13	Sephadex	Sephadex	NNP
cord-006860-a3b8hyyr	1984	14	extraction	extraction	NN
cord-006860-a3b8hyyr	1984	15	of	of	IN
cord-006860-a3b8hyyr	1984	16	cryopeer	cryopeer	NN
cord-006860-a3b8hyyr	1984	17	plasma	plasma	NN
cord-006860-a3b8hyyr	1984	18	followed	follow	VBN
cord-006860-a3b8hyyr	1984	19	by	by	IN
cord-006860-a3b8hyyr	1984	20	a	a	DT
cord-006860-a3b8hyyr	1984	21	solvent	solvent	NN
cord-006860-a3b8hyyr	1984	22	/	/	SYM
cord-006860-a3b8hyyr	1984	23	detergent	detergent	NN
cord-006860-a3b8hyyr	1984	24	virus	virus	NN
cord-006860-a3b8hyyr	1984	25	inactivation	inactivation	NN
cord-006860-a3b8hyyr	1984	26	step	step	NN
cord-006860-a3b8hyyr	1984	27	.	.	.
cord-006860-a3b8hyyr	1985	1	Further	further	JJ
cord-006860-a3b8hyyr	1985	2	purification	purification	NN
cord-006860-a3b8hyyr	1985	3	is	be	VBZ
cord-006860-a3b8hyyr	1985	4	achieved	achieve	VBN
cord-006860-a3b8hyyr	1985	5	by	by	IN
cord-006860-a3b8hyyr	1985	6	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	1985	7	chromatography	chromatography	NN
cord-006860-a3b8hyyr	1985	8	on	on	IN
cord-006860-a3b8hyyr	1985	9	DEAE	DEAE	NNP
cord-006860-a3b8hyyr	1985	10	-	-	HYPH
cord-006860-a3b8hyyr	1985	11	Sephamse	Sephamse	NNP
cord-006860-a3b8hyyr	1985	12	.	.	.
cord-006860-a3b8hyyr	1986	1	The	the	DT
cord-006860-a3b8hyyr	1986	2	aim	aim	NN
cord-006860-a3b8hyyr	1986	3	of	of	IN
cord-006860-a3b8hyyr	1986	4	this	this	DT
cord-006860-a3b8hyyr	1986	5	study	study	NN
cord-006860-a3b8hyyr	1986	6	was	be	VBD
cord-006860-a3b8hyyr	1986	7	to	to	TO
cord-006860-a3b8hyyr	1986	8	improve	improve	VB
cord-006860-a3b8hyyr	1986	9	product	product	NN
cord-006860-a3b8hyyr	1986	10	quality	quality	NN
cord-006860-a3b8hyyr	1986	11	by	by	IN
cord-006860-a3b8hyyr	1986	12	avoiding	avoid	VBG
cord-006860-a3b8hyyr	1986	13	F	F	NNP
cord-006860-a3b8hyyr	1986	14	VIIactivation	viiactivation	NN
cord-006860-a3b8hyyr	1986	15	without	without	IN
cord-006860-a3b8hyyr	1986	16	implementing	implement	VBG
cord-006860-a3b8hyyr	1986	17	major	major	JJ
cord-006860-a3b8hyyr	1986	18	changes	change	NNS
cord-006860-a3b8hyyr	1986	19	to	to	IN
cord-006860-a3b8hyyr	1986	20	the	the	DT
cord-006860-a3b8hyyr	1986	21	production	production	NN
cord-006860-a3b8hyyr	1986	22	process	process	NN
cord-006860-a3b8hyyr	1986	23	.	.	.
cord-006860-a3b8hyyr	1987	1	At	at	IN
cord-006860-a3b8hyyr	1987	2	the	the	DT
cord-006860-a3b8hyyr	1987	3	same	same	JJ
cord-006860-a3b8hyyr	1987	4	time	time	NN
cord-006860-a3b8hyyr	1987	5	,	,	,
cord-006860-a3b8hyyr	1987	6	a	a	DT
cord-006860-a3b8hyyr	1987	7	second	second	JJ
cord-006860-a3b8hyyr	1987	8	virus	virus	NN
cord-006860-a3b8hyyr	1987	9	eliminating	eliminate	VBG
cord-006860-a3b8hyyr	1987	10	step	step	NN
cord-006860-a3b8hyyr	1987	11	was	be	VBD
cord-006860-a3b8hyyr	1987	12	added	add	VBN
cord-006860-a3b8hyyr	1987	13	to	to	IN
cord-006860-a3b8hyyr	1987	14	the	the	DT
cord-006860-a3b8hyyr	1987	15	production	production	NN
cord-006860-a3b8hyyr	1987	16	process	process	NN
cord-006860-a3b8hyyr	1987	17	.	.	.
cord-006860-a3b8hyyr	1988	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	1988	2	could	could	MD
cord-006860-a3b8hyyr	1988	3	be	be	VB
cord-006860-a3b8hyyr	1988	4	shown	show	VBN
cord-006860-a3b8hyyr	1988	5	that	that	IN
cord-006860-a3b8hyyr	1988	6	speeding	speed	VBG
cord-006860-a3b8hyyr	1988	7	up	up	RP
cord-006860-a3b8hyyr	1988	8	the	the	DT
cord-006860-a3b8hyyr	1988	9	chromatographical	chromatographical	JJ
cord-006860-a3b8hyyr	1988	10	process	process	NN
cord-006860-a3b8hyyr	1988	11	by	by	IN
cord-006860-a3b8hyyr	1988	12	switching	switch	VBG
cord-006860-a3b8hyyr	1988	13	the	the	DT
cord-006860-a3b8hyyr	1988	14	DEAE	DEAE	NNP
cord-006860-a3b8hyyr	1988	15	-	-	HYPH
cord-006860-a3b8hyyr	1988	16	Sepharose	Sepharose	NNP
cord-006860-a3b8hyyr	1988	17	-	-	HYPH
cord-006860-a3b8hyyr	1988	18	chromatography	chromatography	NN
cord-006860-a3b8hyyr	1988	19	from	from	IN
cord-006860-a3b8hyyr	1988	20	a	a	DT
cord-006860-a3b8hyyr	1988	21	classical	classical	JJ
cord-006860-a3b8hyyr	1988	22	axial	axial	JJ
cord-006860-a3b8hyyr	1988	23	column	column	NN
cord-006860-a3b8hyyr	1988	24	to	to	IN
cord-006860-a3b8hyyr	1988	25	a	a	DT
cord-006860-a3b8hyyr	1988	26	radial	radial	JJ
cord-006860-a3b8hyyr	1988	27	chromatography	chromatography	NN
cord-006860-a3b8hyyr	1988	28	resulted	result	VBD
cord-006860-a3b8hyyr	1988	29	in	in	IN
cord-006860-a3b8hyyr	1988	30	a	a	DT
cord-006860-a3b8hyyr	1988	31	significant	significant	JJ
cord-006860-a3b8hyyr	1988	32	reduction	reduction	NN
cord-006860-a3b8hyyr	1988	33	of	of	IN
cord-006860-a3b8hyyr	1988	34	F	F	NNP
cord-006860-a3b8hyyr	1988	35	VIIa	VIIa	NNP
cord-006860-a3b8hyyr	1988	36	-	-	HYPH
cord-006860-a3b8hyyr	1988	37	genemtion	genemtion	NNP
cord-006860-a3b8hyyr	1988	38	.	.	.
cord-006860-a3b8hyyr	1989	1	Mainly	mainly	RB
cord-006860-a3b8hyyr	1989	2	the	the	DT
cord-006860-a3b8hyyr	1989	3	reduction	reduction	NN
cord-006860-a3b8hyyr	1989	4	of	of	IN
cord-006860-a3b8hyyr	1989	5	contact	contact	NN
cord-006860-a3b8hyyr	1989	6	time	time	NN
cord-006860-a3b8hyyr	1989	7	,	,	,
cord-006860-a3b8hyyr	1989	8	resulting	result	VBG
cord-006860-a3b8hyyr	1989	9	from	from	IN
cord-006860-a3b8hyyr	1989	10	the	the	DT
cord-006860-a3b8hyyr	1989	11	highest	high	JJS
cord-006860-a3b8hyyr	1989	12	possible	possible	JJ
cord-006860-a3b8hyyr	1989	13	flow	flow	NN
cord-006860-a3b8hyyr	1989	14	rates	rate	NNS
cord-006860-a3b8hyyr	1989	15	,	,	,
cord-006860-a3b8hyyr	1989	16	leads	lead	VBZ
cord-006860-a3b8hyyr	1989	17	to	to	IN
cord-006860-a3b8hyyr	1989	18	the	the	DT
cord-006860-a3b8hyyr	1989	19	wanted	want	VBN
cord-006860-a3b8hyyr	1989	20	effect	effect	NN
cord-006860-a3b8hyyr	1989	21	.	.	.
cord-006860-a3b8hyyr	1990	1	The	the	DT
cord-006860-a3b8hyyr	1990	2	relation	relation	NN
cord-006860-a3b8hyyr	1990	3	between	between	IN
cord-006860-a3b8hyyr	1990	4	F	F	NNP
cord-006860-a3b8hyyr	1990	5	VII	VII	NNP
cord-006860-a3b8hyyr	1990	6	/	/	SYM
cord-006860-a3b8hyyr	1990	7	F	F	NNP
cord-006860-a3b8hyyr	1990	8	VIIa	VIIa	NNS
cord-006860-a3b8hyyr	1990	9	was	be	VBD
cord-006860-a3b8hyyr	1990	10	10	10	CD
cord-006860-a3b8hyyr	1990	11	:	:	SYM
cord-006860-a3b8hyyr	1990	12	1	1	CD
cord-006860-a3b8hyyr	1990	13	or	or	CC
cord-006860-a3b8hyyr	1990	14	more	more	JJR
cord-006860-a3b8hyyr	1990	15	.	.	.
cord-006860-a3b8hyyr	1991	1	In	in	IN
cord-006860-a3b8hyyr	1991	2	order	order	NN
cord-006860-a3b8hyyr	1991	3	to	to	TO
cord-006860-a3b8hyyr	1991	4	investigate	investigate	VB
cord-006860-a3b8hyyr	1991	5	the	the	DT
cord-006860-a3b8hyyr	1991	6	feasibility	feasibility	NN
cord-006860-a3b8hyyr	1991	7	of	of	IN
cord-006860-a3b8hyyr	1991	8	virus	virus	NN
cord-006860-a3b8hyyr	1991	9	filtration	filtration	NN
cord-006860-a3b8hyyr	1991	10	the	the	DT
cord-006860-a3b8hyyr	1991	11	eluate	eluate	NN
cord-006860-a3b8hyyr	1991	12	of	of	IN
cord-006860-a3b8hyyr	1991	13	the	the	DT
cord-006860-a3b8hyyr	1991	14	DEAE	DEAE	NNP
cord-006860-a3b8hyyr	1991	15	-	-	HYPH
cord-006860-a3b8hyyr	1991	16	Sepharose	Sepharose	NNP
cord-006860-a3b8hyyr	1991	17	column	column	NN
cord-006860-a3b8hyyr	1991	18	was	be	VBD
cord-006860-a3b8hyyr	1991	19	filtered	filter	VBN
cord-006860-a3b8hyyr	1991	20	through	through	IN
cord-006860-a3b8hyyr	1991	21	a	a	DT
cord-006860-a3b8hyyr	1991	22	virus	virus	NN
cord-006860-a3b8hyyr	1991	23	removing	remove	VBG
cord-006860-a3b8hyyr	1991	24	Ultipor	Ultipor	NNP
cord-006860-a3b8hyyr	1991	25	VFfilter	VFfilter	NNP
cord-006860-a3b8hyyr	1991	26	.	.	.
cord-006860-a3b8hyyr	1992	1	The	the	DT
cord-006860-a3b8hyyr	1992	2	analysis	analysis	NN
cord-006860-a3b8hyyr	1992	3	of	of	IN
cord-006860-a3b8hyyr	1992	4	the	the	DT
cord-006860-a3b8hyyr	1992	5	solution	solution	NN
cord-006860-a3b8hyyr	1992	6	before	before	IN
cord-006860-a3b8hyyr	1992	7	and	and	CC
cord-006860-a3b8hyyr	1992	8	after	after	IN
cord-006860-a3b8hyyr	1992	9	fillration	fillration	NN
cord-006860-a3b8hyyr	1992	10	showed	show	VBD
cord-006860-a3b8hyyr	1992	11	that	that	IN
cord-006860-a3b8hyyr	1992	12	the	the	DT
cord-006860-a3b8hyyr	1992	13	filtration	filtration	NN
cord-006860-a3b8hyyr	1992	14	had	have	VBD
cord-006860-a3b8hyyr	1992	15	no	no	DT
cord-006860-a3b8hyyr	1992	16	influence	influence	NN
cord-006860-a3b8hyyr	1992	17	on	on	IN
cord-006860-a3b8hyyr	1992	18	coagulation	coagulation	NN
cord-006860-a3b8hyyr	1992	19	factors	factor	NNS
cord-006860-a3b8hyyr	1992	20	activity	activity	NN
cord-006860-a3b8hyyr	1992	21	,	,	,
cord-006860-a3b8hyyr	1992	22	protein	protein	NN
cord-006860-a3b8hyyr	1992	23	content	content	NN
cord-006860-a3b8hyyr	1992	24	,	,	,
cord-006860-a3b8hyyr	1992	25	proteolytic	proteolytic	JJ
cord-006860-a3b8hyyr	1992	26	activity	activity	NN
cord-006860-a3b8hyyr	1992	27	etc	etc	NN
cord-006860-a3b8hyyr	1992	28	.	.	.
cord-006860-a3b8hyyr	1993	1	Preliminary	preliminary	JJ
cord-006860-a3b8hyyr	1993	2	studies	study	NNS
cord-006860-a3b8hyyr	1993	3	showed	show	VBD
cord-006860-a3b8hyyr	1993	4	significant	significant	JJ
cord-006860-a3b8hyyr	1993	5	virus	virus	NN
cord-006860-a3b8hyyr	1993	6	reduction	reduction	NN
cord-006860-a3b8hyyr	1993	7	values	value	NNS
cord-006860-a3b8hyyr	1993	8	.	.	.
cord-006860-a3b8hyyr	1994	1	In	in	IN
cord-006860-a3b8hyyr	1994	2	the	the	DT
cord-006860-a3b8hyyr	1994	3	past	past	JJ
cord-006860-a3b8hyyr	1994	4	few	few	JJ
cord-006860-a3b8hyyr	1994	5	years	year	NNS
cord-006860-a3b8hyyr	1994	6	the	the	DT
cord-006860-a3b8hyyr	1994	7	problem	problem	NN
cord-006860-a3b8hyyr	1994	8	of	of	IN
cord-006860-a3b8hyyr	1994	9	expediency	expediency	NN
cord-006860-a3b8hyyr	1994	10	of	of	IN
cord-006860-a3b8hyyr	1994	11	the	the	DT
cord-006860-a3b8hyyr	1994	12	treatment	treatment	NN
cord-006860-a3b8hyyr	1994	13	aimed	aim	VBN
cord-006860-a3b8hyyr	1994	14	at	at	IN
cord-006860-a3b8hyyr	1994	15	developing	develop	VBG
cord-006860-a3b8hyyr	1994	16	immunological	immunological	JJ
cord-006860-a3b8hyyr	1994	17	tolerance	tolerance	NN
cord-006860-a3b8hyyr	1994	18	in	in	IN
cord-006860-a3b8hyyr	1994	19	hemophil;a	hemophil;a	NNP
cord-006860-a3b8hyyr	1994	20	patients	patient	NNS
cord-006860-a3b8hyyr	1994	21	by	by	IN
cord-006860-a3b8hyyr	1994	22	way	way	NN
cord-006860-a3b8hyyr	1994	23	of	of	IN
cord-006860-a3b8hyyr	1994	24	complete	complete	JJ
cord-006860-a3b8hyyr	1994	25	removal	removal	NN
cord-006860-a3b8hyyr	1994	26	of	of	IN
cord-006860-a3b8hyyr	1994	27	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	1994	28	with	with	IN
cord-006860-a3b8hyyr	1994	29	high	high	JJ
cord-006860-a3b8hyyr	1994	30	doses	dose	NNS
cord-006860-a3b8hyyr	1994	31	of	of	IN
cord-006860-a3b8hyyr	1994	32	factor	factor	NN
cord-006860-a3b8hyyr	1994	33	VIII	VIII	NNP
cord-006860-a3b8hyyr	1994	34	has	have	VBZ
cord-006860-a3b8hyyr	1994	35	been	be	VBN
cord-006860-a3b8hyyr	1994	36	discussed	discuss	VBN
cord-006860-a3b8hyyr	1994	37	in	in	IN
cord-006860-a3b8hyyr	1994	38	literature	literature	NN
cord-006860-a3b8hyyr	1994	39	.	.	.
cord-006860-a3b8hyyr	1995	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	1995	2	observed	observe	VBD
cord-006860-a3b8hyyr	1995	3	121	121	CD
cord-006860-a3b8hyyr	1995	4	patients	patient	NNS
cord-006860-a3b8hyyr	1995	5	with	with	IN
cord-006860-a3b8hyyr	1995	6	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	1995	7	.	.	.
cord-006860-a3b8hyyr	1996	1	Inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	1996	2	to	to	TO
cord-006860-a3b8hyyr	1996	3	factor	factor	VB
cord-006860-a3b8hyyr	1996	4	VIII	VIII	NNP
cord-006860-a3b8hyyr	1996	5	:	:	:
cord-006860-a3b8hyyr	1997	1	C	C	NNP
cord-006860-a3b8hyyr	1997	2	were	be	VBD
cord-006860-a3b8hyyr	1997	3	revealed	reveal	VBN
cord-006860-a3b8hyyr	1997	4	in	in	IN
cord-006860-a3b8hyyr	1997	5	32.7	32.7	CD
cord-006860-a3b8hyyr	1997	6	%	%	NN
cord-006860-a3b8hyyr	1997	7	of	of	IN
cord-006860-a3b8hyyr	1997	8	patients	patient	NNS
cord-006860-a3b8hyyr	1997	9	with	with	IN
cord-006860-a3b8hyyr	1997	10	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	1997	11	A	A	NNP
cord-006860-a3b8hyyr	1997	12	and	and	CC
cord-006860-a3b8hyyr	1997	13	fo	fo	IN
cord-006860-a3b8hyyr	1997	14	factor	factor	NN
cord-006860-a3b8hyyr	1997	15	IX	IX	NNP
cord-006860-a3b8hyyr	1997	16	--in	--in	NNP
cord-006860-a3b8hyyr	1997	17	1.6	1.6	CD
cord-006860-a3b8hyyr	1997	18	%	%	NN
cord-006860-a3b8hyyr	1997	19	of	of	IN
cord-006860-a3b8hyyr	1997	20	patients	patient	NNS
cord-006860-a3b8hyyr	1997	21	with	with	IN
cord-006860-a3b8hyyr	1997	22	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	1997	23	B.	B.	NNP
cord-006860-a3b8hyyr	1998	1	The	the	DT
cord-006860-a3b8hyyr	1998	2	level	level	NN
cord-006860-a3b8hyyr	1998	3	of	of	IN
cord-006860-a3b8hyyr	1998	4	an	an	DT
cord-006860-a3b8hyyr	1998	5	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	1998	6	was	be	VBD
cord-006860-a3b8hyyr	1998	7	not	not	RB
cord-006860-a3b8hyyr	1998	8	higher	high	JJR
cord-006860-a3b8hyyr	1998	9	than	than	IN
cord-006860-a3b8hyyr	1998	10	87	87	CD
cord-006860-a3b8hyyr	1999	1	Befhesda	Befhesda	NNP
cord-006860-a3b8hyyr	1999	2	U	U	NNP
cord-006860-a3b8hyyr	1999	3	/	/	SYM
cord-006860-a3b8hyyr	1999	4	ml	ml	XX
cord-006860-a3b8hyyr	1999	5	,	,	,
cord-006860-a3b8hyyr	1999	6	that	that	DT
cord-006860-a3b8hyyr	1999	7	is	be	VBZ
cord-006860-a3b8hyyr	1999	8	those	those	DT
cord-006860-a3b8hyyr	1999	9	patients	patient	NNS
cord-006860-a3b8hyyr	1999	10	were	be	VBD
cord-006860-a3b8hyyr	1999	11	not	not	RB
cord-006860-a3b8hyyr	1999	12	regarded	regard	VBN
cord-006860-a3b8hyyr	1999	13	as	as	IN
cord-006860-a3b8hyyr	1999	14	"	"	``
cord-006860-a3b8hyyr	1999	15	high	high	JJ
cord-006860-a3b8hyyr	1999	16	responders	responder	NNS
cord-006860-a3b8hyyr	1999	17	"	"	''
cord-006860-a3b8hyyr	1999	18	.	.	.
cord-006860-a3b8hyyr	2000	1	A	a	DT
cord-006860-a3b8hyyr	2000	2	high	high	JJ
cord-006860-a3b8hyyr	2000	3	incidence	incidence	NN
cord-006860-a3b8hyyr	2000	4	of	of	IN
cord-006860-a3b8hyyr	2000	5	inhibifors	inhibifor	NNS
cord-006860-a3b8hyyr	2000	6	in	in	IN
cord-006860-a3b8hyyr	2000	7	young	young	JJ
cord-006860-a3b8hyyr	2000	8	patients	patient	NNS
cord-006860-a3b8hyyr	2000	9	[	[	-LRB-
cord-006860-a3b8hyyr	2000	10	from	from	IN
cord-006860-a3b8hyyr	2000	11	7	7	CD
cord-006860-a3b8hyyr	2000	12	to	to	TO
cord-006860-a3b8hyyr	2000	13	26	26	CD
cord-006860-a3b8hyyr	2000	14	years	year	NNS
cord-006860-a3b8hyyr	2000	15	of	of	IN
cord-006860-a3b8hyyr	2000	16	age	age	NN
cord-006860-a3b8hyyr	2000	17	,	,	,
cord-006860-a3b8hyyr	2000	18	51.9	51.9	CD
cord-006860-a3b8hyyr	2000	19	%	%	NN
cord-006860-a3b8hyyr	2000	20	)	)	-RRB-
cord-006860-a3b8hyyr	2000	21	compared	compare	VBN
cord-006860-a3b8hyyr	2000	22	with	with	IN
cord-006860-a3b8hyyr	2000	23	older	old	JJR
cord-006860-a3b8hyyr	2000	24	patients	patient	NNS
cord-006860-a3b8hyyr	2000	25	(	(	-LRB-
cord-006860-a3b8hyyr	2000	26	from	from	IN
cord-006860-a3b8hyyr	2000	27	27	27	CD
cord-006860-a3b8hyyr	2000	28	to	to	TO
cord-006860-a3b8hyyr	2000	29	40	40	CD
cord-006860-a3b8hyyr	2000	30	years	year	NNS
cord-006860-a3b8hyyr	2000	31	of	of	IN
cord-006860-a3b8hyyr	2000	32	age	age	NN
cord-006860-a3b8hyyr	2000	33	,	,	,
cord-006860-a3b8hyyr	2000	34	11.2	11.2	CD
cord-006860-a3b8hyyr	2000	35	%	%	NN
cord-006860-a3b8hyyr	2000	36	)	)	-RRB-
cord-006860-a3b8hyyr	2000	37	testifies	testify	VBZ
cord-006860-a3b8hyyr	2000	38	to	to	IN
cord-006860-a3b8hyyr	2000	39	the	the	DT
cord-006860-a3b8hyyr	2000	40	probability	probability	NN
cord-006860-a3b8hyyr	2000	41	of	of	IN
cord-006860-a3b8hyyr	2000	42	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2000	43	development	development	NN
cord-006860-a3b8hyyr	2000	44	during	during	IN
cord-006860-a3b8hyyr	2000	45	treatment	treatment	NN
cord-006860-a3b8hyyr	2000	46	with	with	IN
cord-006860-a3b8hyyr	2000	47	modern	modern	JJ
cord-006860-a3b8hyyr	2000	48	concentrated	concentrated	JJ
cord-006860-a3b8hyyr	2000	49	preparation	preparation	NN
cord-006860-a3b8hyyr	2000	50	of	of	IN
cord-006860-a3b8hyyr	2000	51	factor	factor	NN
cord-006860-a3b8hyyr	2000	52	VIII	VIII	NNP
cord-006860-a3b8hyyr	2000	53	,	,	,
cord-006860-a3b8hyyr	2000	54	IX	IX	NNP
cord-006860-a3b8hyyr	2000	55	.	.	.
cord-006860-a3b8hyyr	2001	1	Inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2001	2	development	development	NN
cord-006860-a3b8hyyr	2001	3	in	in	IN
cord-006860-a3b8hyyr	2001	4	patients	patient	NNS
cord-006860-a3b8hyyr	2001	5	(	(	-LRB-
cord-006860-a3b8hyyr	2001	6	40.5	40.5	CD
cord-006860-a3b8hyyr	2001	7	%	%	NN
cord-006860-a3b8hyyr	2001	8	]	]	-RRB-
cord-006860-a3b8hyyr	2002	1	in	in	IN
cord-006860-a3b8hyyr	2002	2	the	the	DT
cord-006860-a3b8hyyr	2002	3	course	course	NN
cord-006860-a3b8hyyr	2002	4	of	of	IN
cord-006860-a3b8hyyr	2002	5	antihemophilic	antihemophilic	NN
cord-006860-a3b8hyyr	2002	6	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	2002	7	transfusions	transfusion	NNS
cord-006860-a3b8hyyr	2002	8	is	be	VBZ
cord-006860-a3b8hyyr	2002	9	an	an	DT
cord-006860-a3b8hyyr	2002	10	evidence	evidence	NN
cord-006860-a3b8hyyr	2002	11	of	of	IN
cord-006860-a3b8hyyr	2002	12	alloimmunization	alloimmunization	NN
cord-006860-a3b8hyyr	2002	13	of	of	IN
cord-006860-a3b8hyyr	2002	14	patients	patient	NNS
cord-006860-a3b8hyyr	2002	15	with	with	IN
cord-006860-a3b8hyyr	2002	16	proteins	protein	NNS
cord-006860-a3b8hyyr	2002	17	.	.	.
cord-006860-a3b8hyyr	2003	1	The	the	DT
cord-006860-a3b8hyyr	2003	2	investigations	investigation	NNS
cord-006860-a3b8hyyr	2003	3	show	show	VBP
cord-006860-a3b8hyyr	2003	4	that	that	IN
cord-006860-a3b8hyyr	2003	5	in	in	IN
cord-006860-a3b8hyyr	2003	6	the	the	DT
cord-006860-a3b8hyyr	2003	7	course	course	NN
cord-006860-a3b8hyyr	2003	8	of	of	IN
cord-006860-a3b8hyyr	2003	9	transfusion	transfusion	NN
cord-006860-a3b8hyyr	2003	10	therapy	therapy	NN
cord-006860-a3b8hyyr	2003	11	patients	patient	NNS
cord-006860-a3b8hyyr	2003	12	develop	develop	VBP
cord-006860-a3b8hyyr	2003	13	secondary	secondary	JJ
cord-006860-a3b8hyyr	2003	14	immunodeficiency	immunodeficiency	NN
cord-006860-a3b8hyyr	2003	15	due	due	IN
cord-006860-a3b8hyyr	2003	16	to	to	IN
cord-006860-a3b8hyyr	2003	17	chronic	chronic	JJ
cord-006860-a3b8hyyr	2003	18	antigenic	antigenic	JJ
cord-006860-a3b8hyyr	2003	19	stimulation	stimulation	NN
cord-006860-a3b8hyyr	2003	20	of	of	IN
cord-006860-a3b8hyyr	2003	21	immune	immune	JJ
cord-006860-a3b8hyyr	2003	22	system	system	NN
cord-006860-a3b8hyyr	2003	23	with	with	IN
cord-006860-a3b8hyyr	2003	24	high	high	JJ
cord-006860-a3b8hyyr	2003	25	doses	dose	NNS
cord-006860-a3b8hyyr	2003	26	of	of	IN
cord-006860-a3b8hyyr	2003	27	allogenic	allogenic	JJ
cord-006860-a3b8hyyr	2003	28	proteins	protein	NNS
cord-006860-a3b8hyyr	2003	29	.	.	.
cord-006860-a3b8hyyr	2004	1	Against	against	IN
cord-006860-a3b8hyyr	2004	2	the	the	DT
cord-006860-a3b8hyyr	2004	3	background	background	NN
cord-006860-a3b8hyyr	2004	4	of	of	IN
cord-006860-a3b8hyyr	2004	5	immunodeficiency	immunodeficiency	NN
cord-006860-a3b8hyyr	2004	6	patients	patient	NNS
cord-006860-a3b8hyyr	2004	7	with	with	IN
cord-006860-a3b8hyyr	2004	8	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2004	9	develop	develop	VBP
cord-006860-a3b8hyyr	2004	10	complications	complication	NNS
cord-006860-a3b8hyyr	2004	11	of	of	IN
cord-006860-a3b8hyyr	2004	12	immune	immune	JJ
cord-006860-a3b8hyyr	2004	13	character	character	NN
cord-006860-a3b8hyyr	2004	14	:	:	:
cord-006860-a3b8hyyr	2004	15	infections	infection	NNS
cord-006860-a3b8hyyr	2004	16	complications	complication	NNS
cord-006860-a3b8hyyr	2004	17	--53.9	--53.9	:
cord-006860-a3b8hyyr	2004	18	%	%	NN
cord-006860-a3b8hyyr	2004	19	,	,	,
cord-006860-a3b8hyyr	2004	20	aufoimmune	aufoimmune	NNP
cord-006860-a3b8hyyr	2004	21	processes	process	NNS
cord-006860-a3b8hyyr	2004	22	--44.9	--44.9	CD
cord-006860-a3b8hyyr	2004	23	%	%	NN
cord-006860-a3b8hyyr	2004	24	,	,	,
cord-006860-a3b8hyyr	2004	25	secondary	secondary	JJ
cord-006860-a3b8hyyr	2004	26	tumours	tumour	NNS
cord-006860-a3b8hyyr	2004	27	--1.2	--1.2	CD
cord-006860-a3b8hyyr	2004	28	%	%	NN
cord-006860-a3b8hyyr	2004	29	.	.	.
cord-006860-a3b8hyyr	2005	1	Plasmapheresis	Plasmapheresis	NNP
cord-006860-a3b8hyyr	2005	2	is	be	VBZ
cord-006860-a3b8hyyr	2005	3	the	the	DT
cord-006860-a3b8hyyr	2005	4	most	most	RBS
cord-006860-a3b8hyyr	2005	5	rational	rational	JJ
cord-006860-a3b8hyyr	2005	6	method	method	NN
cord-006860-a3b8hyyr	2005	7	of	of	IN
cord-006860-a3b8hyyr	2005	8	removing	remove	VBG
cord-006860-a3b8hyyr	2005	9	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2005	10	in	in	IN
cord-006860-a3b8hyyr	2005	11	patients	patient	NNS
cord-006860-a3b8hyyr	2005	12	with	with	IN
cord-006860-a3b8hyyr	2005	13	low	low	JJ
cord-006860-a3b8hyyr	2005	14	level	level	NN
cord-006860-a3b8hyyr	2005	15	of	of	IN
cord-006860-a3b8hyyr	2005	16	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2005	17	(	(	-LRB-
cord-006860-a3b8hyyr	2005	18	"	"	``
cord-006860-a3b8hyyr	2005	19	low	low	JJ
cord-006860-a3b8hyyr	2005	20	responders	responder	NNS
cord-006860-a3b8hyyr	2005	21	"	"	''
cord-006860-a3b8hyyr	2005	22	,	,	,
cord-006860-a3b8hyyr	2005	23	<	<	XX
cord-006860-a3b8hyyr	2005	24	10	10	CD
cord-006860-a3b8hyyr	2005	25	BU/	BU/	NNP
cord-006860-a3b8hyyr	2005	26	ml	ml	NN
cord-006860-a3b8hyyr	2005	27	)	)	-RRB-
cord-006860-a3b8hyyr	2005	28	and	and	CC
cord-006860-a3b8hyyr	2005	29	in	in	IN
cord-006860-a3b8hyyr	2005	30	patients	patient	NNS
cord-006860-a3b8hyyr	2005	31	with	with	IN
cord-006860-a3b8hyyr	2005	32	mean	mean	JJ
cord-006860-a3b8hyyr	2005	33	response	response	NN
cord-006860-a3b8hyyr	2005	34	.	.	.
cord-006860-a3b8hyyr	2006	1	Thus	thus	RB
cord-006860-a3b8hyyr	2006	2	it	-PRON-	PRP
cord-006860-a3b8hyyr	2006	3	should	should	MD
cord-006860-a3b8hyyr	2006	4	be	be	VB
cord-006860-a3b8hyyr	2006	5	noted	note	VBN
cord-006860-a3b8hyyr	2006	6	that	that	IN
cord-006860-a3b8hyyr	2006	7	the	the	DT
cord-006860-a3b8hyyr	2006	8	treatment	treatment	NN
cord-006860-a3b8hyyr	2006	9	of	of	IN
cord-006860-a3b8hyyr	2006	10	patients	patient	NNS
cord-006860-a3b8hyyr	2006	11	aimed	aim	VBN
cord-006860-a3b8hyyr	2006	12	at	at	IN
cord-006860-a3b8hyyr	2006	13	developing	develop	VBG
cord-006860-a3b8hyyr	2006	14	immunological	immunological	JJ
cord-006860-a3b8hyyr	2006	15	tolerance	tolerance	NN
cord-006860-a3b8hyyr	2006	16	is	be	VBZ
cord-006860-a3b8hyyr	2006	17	not	not	RB
cord-006860-a3b8hyyr	2006	18	only	only	RB
cord-006860-a3b8hyyr	2006	19	expensive	expensive	JJ
cord-006860-a3b8hyyr	2006	20	and	and	CC
cord-006860-a3b8hyyr	2006	21	economically	economically	RB
cord-006860-a3b8hyyr	2006	22	unprofitable	unprofitable	JJ
cord-006860-a3b8hyyr	2006	23	but	but	CC
cord-006860-a3b8hyyr	2006	24	also	also	RB
cord-006860-a3b8hyyr	2006	25	not	not	RB
cord-006860-a3b8hyyr	2006	26	indifferent	indifferent	JJ
cord-006860-a3b8hyyr	2006	27	fo	fo	IN
cord-006860-a3b8hyyr	2006	28	the	the	DT
cord-006860-a3b8hyyr	2006	29	organism	organism	NN
cord-006860-a3b8hyyr	2006	30	.	.	.
cord-006860-a3b8hyyr	2007	1	In	in	IN
cord-006860-a3b8hyyr	2007	2	a	a	DT
cord-006860-a3b8hyyr	2007	3	recent	recent	JJ
cord-006860-a3b8hyyr	2007	4	multicenter	multicenter	JJ
cord-006860-a3b8hyyr	2007	5	study	study	NN
cord-006860-a3b8hyyr	2007	6	73	73	CD
cord-006860-a3b8hyyr	2007	7	previously	previously	RB
cord-006860-a3b8hyyr	2007	8	untreated	untreated	JJ
cord-006860-a3b8hyyr	2007	9	patientens	patienten	NNS
cord-006860-a3b8hyyr	2007	10	(	(	-LRB-
cord-006860-a3b8hyyr	2007	11	PUPs	pup	NNS
cord-006860-a3b8hyyr	2007	12	)	)	-RRB-
cord-006860-a3b8hyyr	2007	13	with	with	IN
cord-006860-a3b8hyyr	2007	14	severe	severe	JJ
cord-006860-a3b8hyyr	2007	15	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2007	16	A	A	NNP
cord-006860-a3b8hyyr	2007	17	were	be	VBD
cord-006860-a3b8hyyr	2007	18	treated	treat	VBN
cord-006860-a3b8hyyr	2007	19	with	with	IN
cord-006860-a3b8hyyr	2007	20	a	a	DT
cord-006860-a3b8hyyr	2007	21	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	2007	22	factor	factor	NN
cord-006860-a3b8hyyr	2007	23	VIII	VIII	NNP
cord-006860-a3b8hyyr	2007	24	concentrate	concentrate	NN
cord-006860-a3b8hyyr	2007	25	(	(	-LRB-
cord-006860-a3b8hyyr	2007	26	rfVIII	rfviii	XX
cord-006860-a3b8hyyr	2007	27	,	,	,
cord-006860-a3b8hyyr	2007	28	Recombinate	Recombinate	NNP
cord-006860-a3b8hyyr	2007	29	©	©	NNP
cord-006860-a3b8hyyr	2007	30	)	)	-RRB-
cord-006860-a3b8hyyr	2007	31	.	.	.
cord-006860-a3b8hyyr	2008	1	During	during	IN
cord-006860-a3b8hyyr	2008	2	fVIII	fviii	NN
cord-006860-a3b8hyyr	2008	3	treatment	treatment	NN
cord-006860-a3b8hyyr	2008	4	21	21	CD
cord-006860-a3b8hyyr	2008	5	(	(	-LRB-
cord-006860-a3b8hyyr	2008	6	29	29	CD
cord-006860-a3b8hyyr	2008	7	%	%	NN
cord-006860-a3b8hyyr	2008	8	)	)	-RRB-
cord-006860-a3b8hyyr	2008	9	developed	develop	VBN
cord-006860-a3b8hyyr	2008	10	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2008	11	,	,	,
cord-006860-a3b8hyyr	2008	12	6	6	CD
cord-006860-a3b8hyyr	2008	13	high	high	JJ
cord-006860-a3b8hyyr	2008	14	titer	titer	NN
cord-006860-a3b8hyyr	2008	15	(	(	-LRB-
cord-006860-a3b8hyyr	2008	16	>	>	NFP
cord-006860-a3b8hyyr	2008	17	5	5	CD
cord-006860-a3b8hyyr	2008	18	Bethesda	Bethesda	NNP
cord-006860-a3b8hyyr	2008	19	units	unit	NNS
cord-006860-a3b8hyyr	2008	20	(	(	-LRB-
cord-006860-a3b8hyyr	2008	21	BU)/ml	BU)/ml	NNP
cord-006860-a3b8hyyr	2008	22	)	)	-RRB-
cord-006860-a3b8hyyr	2008	23	,	,	,
cord-006860-a3b8hyyr	2008	24	4	4	CD
cord-006860-a3b8hyyr	2008	25	low	low	JJ
cord-006860-a3b8hyyr	2008	26	titer	titer	NN
cord-006860-a3b8hyyr	2008	27	(	(	-LRB-
cord-006860-a3b8hyyr	2008	28	<	<	XX
cord-006860-a3b8hyyr	2008	29	5	5	CD
cord-006860-a3b8hyyr	2008	30	BU	BU	NNP
cord-006860-a3b8hyyr	2008	31	/	/	SYM
cord-006860-a3b8hyyr	2008	32	ml	ml	NN
cord-006860-a3b8hyyr	2008	33	)	)	-RRB-
cord-006860-a3b8hyyr	2008	34	and	and	CC
cord-006860-a3b8hyyr	2008	35	11	11	CD
cord-006860-a3b8hyyr	2008	36	transient	transient	JJ
cord-006860-a3b8hyyr	2008	37	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2008	38	.	.	.
cord-006860-a3b8hyyr	2009	1	Plasma	plasma	NN
cord-006860-a3b8hyyr	2009	2	samples	sample	NNS
cord-006860-a3b8hyyr	2009	3	from	from	IN
cord-006860-a3b8hyyr	2009	4	before	before	IN
cord-006860-a3b8hyyr	2009	5	treatment	treatment	NN
cord-006860-a3b8hyyr	2009	6	and	and	CC
cord-006860-a3b8hyyr	2009	7	during	during	IN
cord-006860-a3b8hyyr	2009	8	treatment	treatment	NN
cord-006860-a3b8hyyr	2010	1	but	but	CC
cord-006860-a3b8hyyr	2010	2	before	before	IN
cord-006860-a3b8hyyr	2010	3	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2010	4	occurrence	occurrence	NN
cord-006860-a3b8hyyr	2010	5	were	be	VBD
cord-006860-a3b8hyyr	2010	6	available	available	JJ
cord-006860-a3b8hyyr	2010	7	in	in	IN
cord-006860-a3b8hyyr	2010	8	12	12	CD
cord-006860-a3b8hyyr	2010	9	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2010	10	patients	patient	NNS
cord-006860-a3b8hyyr	2010	11	.	.	.
cord-006860-a3b8hyyr	2011	1	These	these	DT
cord-006860-a3b8hyyr	2011	2	plasma	plasma	NN
cord-006860-a3b8hyyr	2011	3	samples	sample	NNS
cord-006860-a3b8hyyr	2011	4	were	be	VBD
cord-006860-a3b8hyyr	2011	5	analyzed	analyze	VBN
cord-006860-a3b8hyyr	2011	6	by	by	IN
cord-006860-a3b8hyyr	2011	7	a	a	DT
cord-006860-a3b8hyyr	2011	8	highly	highly	RB
cord-006860-a3b8hyyr	2011	9	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	2011	10	immunoprecipitation	immunoprecipitation	NN
cord-006860-a3b8hyyr	2011	11	(	(	-LRB-
cord-006860-a3b8hyyr	2011	12	IP	ip	NN
cord-006860-a3b8hyyr	2011	13	)	)	-RRB-
cord-006860-a3b8hyyr	2011	14	assay	assay	NN
cord-006860-a3b8hyyr	2011	15	for	for	IN
cord-006860-a3b8hyyr	2011	16	the	the	DT
cord-006860-a3b8hyyr	2011	17	presence	presence	NN
cord-006860-a3b8hyyr	2011	18	of	of	IN
cord-006860-a3b8hyyr	2011	19	anti	anti	NNS
cord-006860-a3b8hyyr	2011	20	-	-	JJ
cord-006860-a3b8hyyr	2011	21	tViiI	tviii	JJ
cord-006860-a3b8hyyr	2011	22	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2011	23	.	.	.
cord-006860-a3b8hyyr	2012	1	In	in	IN
cord-006860-a3b8hyyr	2012	2	9	9	CD
cord-006860-a3b8hyyr	2012	3	(	(	-LRB-
cord-006860-a3b8hyyr	2012	4	66	66	CD
cord-006860-a3b8hyyr	2012	5	%	%	NN
cord-006860-a3b8hyyr	2012	6	)	)	-RRB-
cord-006860-a3b8hyyr	2012	7	a	a	DT
cord-006860-a3b8hyyr	2012	8	significant	significant	JJ
cord-006860-a3b8hyyr	2012	9	increase	increase	NN
cord-006860-a3b8hyyr	2012	10	of	of	IN
cord-006860-a3b8hyyr	2012	11	anti	anti	JJ
cord-006860-a3b8hyyr	2012	12	-	-	JJ
cord-006860-a3b8hyyr	2012	13	fV]]I	fv]]i	JJ
cord-006860-a3b8hyyr	2012	14	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2012	15	was	be	VBD
cord-006860-a3b8hyyr	2012	16	seen	see	VBN
cord-006860-a3b8hyyr	2012	17	indicating	indicate	VBG
cord-006860-a3b8hyyr	2012	18	the	the	DT
cord-006860-a3b8hyyr	2012	19	development	development	NN
cord-006860-a3b8hyyr	2012	20	of	of	IN
cord-006860-a3b8hyyr	2012	21	a	a	DT
cord-006860-a3b8hyyr	2012	22	clinical	clinical	JJ
cord-006860-a3b8hyyr	2012	23	relevant	relevant	JJ
cord-006860-a3b8hyyr	2012	24	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2012	25	titer	titer	NN
cord-006860-a3b8hyyr	2012	26	.	.	.
cord-006860-a3b8hyyr	2013	1	This	this	DT
cord-006860-a3b8hyyr	2013	2	immune	immune	JJ
cord-006860-a3b8hyyr	2013	3	response	response	NN
cord-006860-a3b8hyyr	2013	4	occurred	occur	VBD
cord-006860-a3b8hyyr	2013	5	after	after	IN
cord-006860-a3b8hyyr	2013	6	2	2	CD
cord-006860-a3b8hyyr	2013	7	to	to	IN
cord-006860-a3b8hyyr	2013	8	17	17	CD
cord-006860-a3b8hyyr	2013	9	(	(	-LRB-
cord-006860-a3b8hyyr	2013	10	median	median	NN
cord-006860-a3b8hyyr	2013	11	5	5	CD
cord-006860-a3b8hyyr	2013	12	)	)	-RRB-
cord-006860-a3b8hyyr	2013	13	exposure	exposure	NN
cord-006860-a3b8hyyr	2013	14	days	day	NNS
cord-006860-a3b8hyyr	2013	15	(	(	-LRB-
cord-006860-a3b8hyyr	2013	16	ED	ED	NNP
cord-006860-a3b8hyyr	2013	17	)	)	-RRB-
cord-006860-a3b8hyyr	2013	18	.	.	.
cord-006860-a3b8hyyr	2014	1	In	in	IN
cord-006860-a3b8hyyr	2014	2	the	the	DT
cord-006860-a3b8hyyr	2014	3	same	same	JJ
cord-006860-a3b8hyyr	2014	4	period	period	NN
cord-006860-a3b8hyyr	2014	5	only	only	RB
cord-006860-a3b8hyyr	2014	6	3	3	CD
cord-006860-a3b8hyyr	2014	7	out	out	IN
cord-006860-a3b8hyyr	2014	8	of	of	IN
cord-006860-a3b8hyyr	2014	9	15	15	CD
cord-006860-a3b8hyyr	2014	10	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2014	11	patients	patient	NNS
cord-006860-a3b8hyyr	2014	12	showed	show	VBD
cord-006860-a3b8hyyr	2014	13	a	a	DT
cord-006860-a3b8hyyr	2014	14	decreased	decreased	NN
cord-006860-a3b8hyyr	2014	15	in	in	IN
cord-006860-a3b8hyyr	2014	16	vivo	vivo	NN
cord-006860-a3b8hyyr	2014	17	recovery	recovery	NN
cord-006860-a3b8hyyr	2014	18	.	.	.
cord-006860-a3b8hyyr	2015	1	In	in	IN
cord-006860-a3b8hyyr	2015	2	16	16	CD
cord-006860-a3b8hyyr	2015	3	PUPs	pup	NNS
cord-006860-a3b8hyyr	2015	4	who	who	WP
cord-006860-a3b8hyyr	2015	5	developed	develop	VBD
cord-006860-a3b8hyyr	2015	6	no	no	DT
cord-006860-a3b8hyyr	2015	7	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2015	8	plasma	plasma	NN
cord-006860-a3b8hyyr	2015	9	samples	sample	NNS
cord-006860-a3b8hyyr	2015	10	from	from	IN
cord-006860-a3b8hyyr	2015	11	the	the	DT
cord-006860-a3b8hyyr	2015	12	entire	entire	JJ
cord-006860-a3b8hyyr	2015	13	treatment	treatment	NN
cord-006860-a3b8hyyr	2015	14	period	period	NN
cord-006860-a3b8hyyr	2015	15	were	be	VBD
cord-006860-a3b8hyyr	2015	16	available	available	JJ
cord-006860-a3b8hyyr	2015	17	.	.	.
cord-006860-a3b8hyyr	2016	1	An	an	DT
cord-006860-a3b8hyyr	2016	2	immune	immune	JJ
cord-006860-a3b8hyyr	2016	3	response	response	NN
cord-006860-a3b8hyyr	2016	4	to	to	IN
cord-006860-a3b8hyyr	2016	5	rfVIII	rfviii	CD
cord-006860-a3b8hyyr	2016	6	treatment	treatment	NN
cord-006860-a3b8hyyr	2016	7	was	be	VBD
cord-006860-a3b8hyyr	2016	8	seen	see	VBN
cord-006860-a3b8hyyr	2016	9	in	in	IN
cord-006860-a3b8hyyr	2016	10	7	7	CD
cord-006860-a3b8hyyr	2016	11	PUPs	pup	NNS
cord-006860-a3b8hyyr	2016	12	after	after	IN
cord-006860-a3b8hyyr	2016	13	2	2	CD
cord-006860-a3b8hyyr	2016	14	to	to	IN
cord-006860-a3b8hyyr	2016	15	43	43	CD
cord-006860-a3b8hyyr	2016	16	ED	ED	NNP
cord-006860-a3b8hyyr	2016	17	(	(	-LRB-
cord-006860-a3b8hyyr	2016	18	median	median	JJ
cord-006860-a3b8hyyr	2016	19	24	24	CD
cord-006860-a3b8hyyr	2016	20	ED	ED	NNP
cord-006860-a3b8hyyr	2016	21	)	)	-RRB-
cord-006860-a3b8hyyr	2016	22	.	.	.
cord-006860-a3b8hyyr	2017	1	The	the	DT
cord-006860-a3b8hyyr	2017	2	immune	immune	JJ
cord-006860-a3b8hyyr	2017	3	response	response	NN
cord-006860-a3b8hyyr	2017	4	was	be	VBD
cord-006860-a3b8hyyr	2017	5	later	later	RB
cord-006860-a3b8hyyr	2017	6	and	and	CC
cord-006860-a3b8hyyr	2017	7	less	less	RBR
cord-006860-a3b8hyyr	2017	8	pronounced	pronounced	JJ
cord-006860-a3b8hyyr	2017	9	in	in	IN
cord-006860-a3b8hyyr	2017	10	comparison	comparison	NN
cord-006860-a3b8hyyr	2017	11	to	to	IN
cord-006860-a3b8hyyr	2017	12	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2017	13	PUPs	pup	NNS
cord-006860-a3b8hyyr	2017	14	before	before	IN
cord-006860-a3b8hyyr	2017	15	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2017	16	occurrence	occurrence	NN
cord-006860-a3b8hyyr	2017	17	.	.	.
cord-006860-a3b8hyyr	2018	1	With	with	IN
cord-006860-a3b8hyyr	2018	2	the	the	DT
cord-006860-a3b8hyyr	2018	3	IP	ip	NN
cord-006860-a3b8hyyr	2018	4	method	method	NN
cord-006860-a3b8hyyr	2018	5	the	the	DT
cord-006860-a3b8hyyr	2018	6	detection	detection	NN
cord-006860-a3b8hyyr	2018	7	of	of	IN
cord-006860-a3b8hyyr	2018	8	an	an	DT
cord-006860-a3b8hyyr	2018	9	early	early	JJ
cord-006860-a3b8hyyr	2018	10	immune	immune	JJ
cord-006860-a3b8hyyr	2018	11	response	response	NN
cord-006860-a3b8hyyr	2018	12	is	be	VBZ
cord-006860-a3b8hyyr	2018	13	possible	possible	JJ
cord-006860-a3b8hyyr	2018	14	which	which	WDT
cord-006860-a3b8hyyr	2018	15	might	may	MD
cord-006860-a3b8hyyr	2018	16	be	be	VB
cord-006860-a3b8hyyr	2018	17	predictive	predictive	JJ
cord-006860-a3b8hyyr	2018	18	for	for	IN
cord-006860-a3b8hyyr	2018	19	a	a	DT
cord-006860-a3b8hyyr	2018	20	later	later	JJ
cord-006860-a3b8hyyr	2018	21	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2018	22	development	development	NN
cord-006860-a3b8hyyr	2018	23	.	.	.
cord-006860-a3b8hyyr	2019	1	The	the	DT
cord-006860-a3b8hyyr	2019	2	inclusion	inclusion	NN
cord-006860-a3b8hyyr	2019	3	of	of	IN
cord-006860-a3b8hyyr	2019	4	the	the	DT
cord-006860-a3b8hyyr	2019	5	lip	lip	NN
cord-006860-a3b8hyyr	2019	6	method	method	NN
cord-006860-a3b8hyyr	2019	7	should	should	MD
cord-006860-a3b8hyyr	2019	8	be	be	VB
cord-006860-a3b8hyyr	2019	9	considered	consider	VBN
cord-006860-a3b8hyyr	2019	10	for	for	IN
cord-006860-a3b8hyyr	2019	11	future	future	JJ
cord-006860-a3b8hyyr	2019	12	multicenter	multicenter	JJ
cord-006860-a3b8hyyr	2019	13	PUP	PUP	NNP
cord-006860-a3b8hyyr	2019	14	studies	study	NNS
cord-006860-a3b8hyyr	2019	15	.	.	.
cord-006860-a3b8hyyr	2020	1	In	in	IN
cord-006860-a3b8hyyr	2020	2	the	the	DT
cord-006860-a3b8hyyr	2020	3	past	past	JJ
cord-006860-a3b8hyyr	2020	4	anaphylactie	anaphylactie	NN
cord-006860-a3b8hyyr	2020	5	reactions	reaction	NNS
cord-006860-a3b8hyyr	2020	6	to	to	IN
cord-006860-a3b8hyyr	2020	7	plasma	plasma	NN
cord-006860-a3b8hyyr	2020	8	and	and	CC
cord-006860-a3b8hyyr	2020	9	plasma	plasma	NN
cord-006860-a3b8hyyr	2020	10	components	component	NNS
cord-006860-a3b8hyyr	2020	11	have	have	VBP
cord-006860-a3b8hyyr	2020	12	been	be	VBN
cord-006860-a3b8hyyr	2020	13	a	a	DT
cord-006860-a3b8hyyr	2020	14	common	common	JJ
cord-006860-a3b8hyyr	2020	15	complication	complication	NN
cord-006860-a3b8hyyr	2020	16	of	of	IN
cord-006860-a3b8hyyr	2020	17	replacement	replacement	NN
cord-006860-a3b8hyyr	2020	18	therapy	therapy	NN
cord-006860-a3b8hyyr	2020	19	in	in	IN
cord-006860-a3b8hyyr	2020	20	patients	patient	NNS
cord-006860-a3b8hyyr	2020	21	with	with	IN
cord-006860-a3b8hyyr	2020	22	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2020	23	A	A	NNP
cord-006860-a3b8hyyr	2020	24	and	and	CC
cord-006860-a3b8hyyr	2021	1	B.	B.	NNP
cord-006860-a3b8hyyr	2021	2	We	-PRON-	PRP
cord-006860-a3b8hyyr	2021	3	report	report	VBP
cord-006860-a3b8hyyr	2021	4	on	on	IN
cord-006860-a3b8hyyr	2021	5	3	3	CD
cord-006860-a3b8hyyr	2021	6	severe	severe	JJ
cord-006860-a3b8hyyr	2021	7	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2021	8	episodes	episode	NNS
cord-006860-a3b8hyyr	2021	9	in	in	IN
cord-006860-a3b8hyyr	2021	10	2	2	CD
cord-006860-a3b8hyyr	2021	11	patients	patient	NNS
cord-006860-a3b8hyyr	2021	12	with	with	IN
cord-006860-a3b8hyyr	2021	13	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2021	14	A	A	NNP
cord-006860-a3b8hyyr	2021	15	and	and	CC
cord-006860-a3b8hyyr	2021	16	B	b	NN
cord-006860-a3b8hyyr	2021	17	,	,	,
cord-006860-a3b8hyyr	2021	18	respectively	respectively	RB
cord-006860-a3b8hyyr	2021	19	.	.	.
cord-006860-a3b8hyyr	2022	1	Both	both	DT
cord-006860-a3b8hyyr	2022	2	patients	patient	NNS
cord-006860-a3b8hyyr	2022	3	had	have	VBD
cord-006860-a3b8hyyr	2022	4	a	a	DT
cord-006860-a3b8hyyr	2022	5	history	history	NN
cord-006860-a3b8hyyr	2022	6	of	of	IN
cord-006860-a3b8hyyr	2022	7	life	life	NN
cord-006860-a3b8hyyr	2022	8	threatening	threaten	VBG
cord-006860-a3b8hyyr	2022	9	anaphylactic	anaphylactic	JJ
cord-006860-a3b8hyyr	2022	10	reactions	reaction	NNS
cord-006860-a3b8hyyr	2022	11	after	after	IN
cord-006860-a3b8hyyr	2022	12	exposure	exposure	NN
cord-006860-a3b8hyyr	2022	13	to	to	IN
cord-006860-a3b8hyyr	2022	14	different	different	JJ
cord-006860-a3b8hyyr	2022	15	plasma	plasma	NN
cord-006860-a3b8hyyr	2022	16	derived	derive	VBN
cord-006860-a3b8hyyr	2022	17	clotting	clotting	NN
cord-006860-a3b8hyyr	2022	18	factor	factor	NN
cord-006860-a3b8hyyr	2022	19	concentrations	concentration	NNS
cord-006860-a3b8hyyr	2022	20	including	include	VBG
cord-006860-a3b8hyyr	2022	21	intermediate	intermediate	JJ
cord-006860-a3b8hyyr	2022	22	purity	purity	NN
cord-006860-a3b8hyyr	2022	23	factor	factor	NN
cord-006860-a3b8hyyr	2022	24	VIII	VIII	NNP
cord-006860-a3b8hyyr	2022	25	-	-	:
cord-006860-a3b8hyyr	2022	26	and	and	CC
cord-006860-a3b8hyyr	2022	27	factor	factor	NN
cord-006860-a3b8hyyr	2022	28	IX	ix	NN
cord-006860-a3b8hyyr	2022	29	-	-	HYPH
cord-006860-a3b8hyyr	2022	30	concentrate	concentrate	NNP
cord-006860-a3b8hyyr	2022	31	,	,	,
cord-006860-a3b8hyyr	2022	32	respectively	respectively	RB
cord-006860-a3b8hyyr	2022	33	.	.	.
cord-006860-a3b8hyyr	2023	1	High	high	JJ
cord-006860-a3b8hyyr	2023	2	purity	purity	NN
cord-006860-a3b8hyyr	2023	3	factor	factor	NN
cord-006860-a3b8hyyr	2023	4	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	2023	5	were	be	VBD
cord-006860-a3b8hyyr	2023	6	tolerated	tolerate	VBN
cord-006860-a3b8hyyr	2023	7	well	well	RB
cord-006860-a3b8hyyr	2023	8	without	without	IN
cord-006860-a3b8hyyr	2023	9	any	any	DT
cord-006860-a3b8hyyr	2023	10	allergic	allergic	JJ
cord-006860-a3b8hyyr	2023	11	side	side	NN
cord-006860-a3b8hyyr	2023	12	effects	effect	NNS
cord-006860-a3b8hyyr	2023	13	.	.	.
cord-006860-a3b8hyyr	2024	1	A	a	DT
cord-006860-a3b8hyyr	2024	2	67	67	CD
cord-006860-a3b8hyyr	2024	3	years	year	NNS
cord-006860-a3b8hyyr	2024	4	old	old	JJ
cord-006860-a3b8hyyr	2024	5	patient	patient	NN
cord-006860-a3b8hyyr	2024	6	with	with	IN
cord-006860-a3b8hyyr	2024	7	a	a	DT
cord-006860-a3b8hyyr	2024	8	moderate	moderate	JJ
cord-006860-a3b8hyyr	2024	9	form	form	NN
cord-006860-a3b8hyyr	2024	10	of	of	IN
cord-006860-a3b8hyyr	2024	11	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2024	12	A	a	NN
cord-006860-a3b8hyyr	2024	13	(	(	-LRB-
cord-006860-a3b8hyyr	2024	14	F	F	NNP
cord-006860-a3b8hyyr	2024	15	VIII	VIII	NNP
cord-006860-a3b8hyyr	2024	16	4	4	CD
cord-006860-a3b8hyyr	2024	17	%	%	NN
cord-006860-a3b8hyyr	2024	18	)	)	-RRB-
cord-006860-a3b8hyyr	2024	19	had	have	VBD
cord-006860-a3b8hyyr	2024	20	a	a	DT
cord-006860-a3b8hyyr	2024	21	history	history	NN
cord-006860-a3b8hyyr	2024	22	of	of	IN
cord-006860-a3b8hyyr	2024	23	severe	severe	JJ
cord-006860-a3b8hyyr	2024	24	immediate	immediate	JJ
cord-006860-a3b8hyyr	2024	25	reactions	reaction	NNS
cord-006860-a3b8hyyr	2024	26	with	with	IN
cord-006860-a3b8hyyr	2024	27	skin	skin	NN
cord-006860-a3b8hyyr	2024	28	manifestations	manifestation	NNS
cord-006860-a3b8hyyr	2024	29	and	and	CC
cord-006860-a3b8hyyr	2024	30	bronchospasm	bronchospasm	JJ
cord-006860-a3b8hyyr	2024	31	after	after	IN
cord-006860-a3b8hyyr	2024	32	exposure	exposure	NN
cord-006860-a3b8hyyr	2024	33	to	to	IN
cord-006860-a3b8hyyr	2024	34	fresh	fresh	JJ
cord-006860-a3b8hyyr	2024	35	frozen	frozen	JJ
cord-006860-a3b8hyyr	2024	36	plasma	plasma	NN
cord-006860-a3b8hyyr	2024	37	,	,	,
cord-006860-a3b8hyyr	2024	38	ctyoprecipitate	ctyoprecipitate	NN
cord-006860-a3b8hyyr	2024	39	and	and	CC
cord-006860-a3b8hyyr	2024	40	3	3	CD
cord-006860-a3b8hyyr	2024	41	different	different	JJ
cord-006860-a3b8hyyr	2024	42	plasma	plasma	NN
cord-006860-a3b8hyyr	2024	43	derived	derive	VBN
cord-006860-a3b8hyyr	2024	44	factor	factor	NN
cord-006860-a3b8hyyr	2024	45	VIII	VIII	NNP
cord-006860-a3b8hyyr	2024	46	-	-	:
cord-006860-a3b8hyyr	2024	47	concentrates	concentrate	NNS
cord-006860-a3b8hyyr	2024	48	of	of	IN
cord-006860-a3b8hyyr	2024	49	intermediate	intermediate	JJ
cord-006860-a3b8hyyr	2024	50	purity	purity	NN
cord-006860-a3b8hyyr	2024	51	.	.	.
cord-006860-a3b8hyyr	2025	1	In	in	IN
cord-006860-a3b8hyyr	2025	2	all	all	DT
cord-006860-a3b8hyyr	2025	3	episodes	episode	NNS
cord-006860-a3b8hyyr	2025	4	pretreatment	pretreatment	JJ
cord-006860-a3b8hyyr	2025	5	with	with	IN
cord-006860-a3b8hyyr	2025	6	corticosteroids	corticosteroid	NNS
cord-006860-a3b8hyyr	2025	7	and	and	CC
cord-006860-a3b8hyyr	2025	8	antihistamines	antihistamine	NNS
cord-006860-a3b8hyyr	2025	9	was	be	VBD
cord-006860-a3b8hyyr	2025	10	unsuccessfull	unsuccessfull	JJ
cord-006860-a3b8hyyr	2025	11	in	in	IN
cord-006860-a3b8hyyr	2025	12	avoiding	avoid	VBG
cord-006860-a3b8hyyr	2025	13	severe	severe	JJ
cord-006860-a3b8hyyr	2025	14	bronchospasm	bronchospasm	NN
cord-006860-a3b8hyyr	2025	15	.	.	.
cord-006860-a3b8hyyr	2026	1	Replacement	replacement	NN
cord-006860-a3b8hyyr	2026	2	therapy	therapy	NN
cord-006860-a3b8hyyr	2026	3	with	with	IN
cord-006860-a3b8hyyr	2026	4	two	two	CD
cord-006860-a3b8hyyr	2026	5	different	different	JJ
cord-006860-a3b8hyyr	2026	6	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	2026	7	factor	factor	NN
cord-006860-a3b8hyyr	2026	8	VIII	VIII	NNP
cord-006860-a3b8hyyr	2026	9	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	2026	10	was	be	VBD
cord-006860-a3b8hyyr	2026	11	tolerated	tolerate	VBN
cord-006860-a3b8hyyr	2026	12	well	well	RB
cord-006860-a3b8hyyr	2026	13	without	without	IN
cord-006860-a3b8hyyr	2026	14	any	any	DT
cord-006860-a3b8hyyr	2026	15	side	side	NN
cord-006860-a3b8hyyr	2026	16	effects	effect	NNS
cord-006860-a3b8hyyr	2026	17	.	.	.
cord-006860-a3b8hyyr	2027	1	A	a	DT
cord-006860-a3b8hyyr	2027	2	12	12	CD
cord-006860-a3b8hyyr	2027	3	years	year	NNS
cord-006860-a3b8hyyr	2027	4	old	old	JJ
cord-006860-a3b8hyyr	2027	5	haemophiita	haemophiita	NNP
cord-006860-a3b8hyyr	2027	6	B	B	NNP
cord-006860-a3b8hyyr	2027	7	patient	patient	NN
cord-006860-a3b8hyyr	2027	8	developed	develop	VBD
cord-006860-a3b8hyyr	2027	9	hypersensitivity	hypersensitivity	NN
cord-006860-a3b8hyyr	2027	10	reactions	reaction	NNS
cord-006860-a3b8hyyr	2027	11	to	to	IN
cord-006860-a3b8hyyr	2027	12	prophylactic	prophylactic	JJ
cord-006860-a3b8hyyr	2027	13	factor	factor	NN
cord-006860-a3b8hyyr	2027	14	IX	IX	NNP
cord-006860-a3b8hyyr	2027	15	substitution	substitution	NN
cord-006860-a3b8hyyr	2027	16	,	,	,
cord-006860-a3b8hyyr	2027	17	which	which	WDT
cord-006860-a3b8hyyr	2027	18	could	could	MD
cord-006860-a3b8hyyr	2027	19	be	be	VB
cord-006860-a3b8hyyr	2027	20	overcome	overcome	VBN
cord-006860-a3b8hyyr	2027	21	by	by	IN
cord-006860-a3b8hyyr	2027	22	using	use	VBG
cord-006860-a3b8hyyr	2027	23	a	a	DT
cord-006860-a3b8hyyr	2027	24	factor	factor	NN
cord-006860-a3b8hyyr	2027	25	IX	IX	NNP
cord-006860-a3b8hyyr	2027	26	.concentrate	.concentrate	,
cord-006860-a3b8hyyr	2027	27	with	with	IN
cord-006860-a3b8hyyr	2027	28	improved	improve	VBN
cord-006860-a3b8hyyr	2027	29	purity	purity	NN
cord-006860-a3b8hyyr	2027	30	.	.	.
cord-006860-a3b8hyyr	2028	1	A	a	DT
cord-006860-a3b8hyyr	2028	2	recent	recent	JJ
cord-006860-a3b8hyyr	2028	3	recurrence	recurrence	NN
cord-006860-a3b8hyyr	2028	4	of	of	IN
cord-006860-a3b8hyyr	2028	5	hypersensitMty	hypersensitMty	NNP
cord-006860-a3b8hyyr	2028	6	under	under	IN
cord-006860-a3b8hyyr	2028	7	this	this	DT
cord-006860-a3b8hyyr	2028	8	treatment	treatment	NN
cord-006860-a3b8hyyr	2028	9	was	be	VBD
cord-006860-a3b8hyyr	2028	10	finally	finally	RB
cord-006860-a3b8hyyr	2028	11	overcome	overcome	VBN
cord-006860-a3b8hyyr	2028	12	by	by	IN
cord-006860-a3b8hyyr	2028	13	the	the	DT
cord-006860-a3b8hyyr	2028	14	use	use	NN
cord-006860-a3b8hyyr	2028	15	of	of	IN
cord-006860-a3b8hyyr	2028	16	highly	highly	RB
cord-006860-a3b8hyyr	2028	17	purified	purify	VBN
cord-006860-a3b8hyyr	2028	18	(	(	-LRB-
cord-006860-a3b8hyyr	2028	19	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	2028	20	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2028	21	)	)	-RRB-
cord-006860-a3b8hyyr	2028	22	factor	factor	NN
cord-006860-a3b8hyyr	2028	23	IX	IX	NNP
cord-006860-a3b8hyyr	2028	24	concentrate	concentrate	NN
cord-006860-a3b8hyyr	2028	25	.	.	.
cord-006860-a3b8hyyr	2029	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2029	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	2029	3	from	from	IN
cord-006860-a3b8hyyr	2029	4	these	these	DT
cord-006860-a3b8hyyr	2029	5	findings	finding	NNS
cord-006860-a3b8hyyr	2029	6	that	that	IN
cord-006860-a3b8hyyr	2029	7	high	high	JJ
cord-006860-a3b8hyyr	2029	8	purity	purity	NN
cord-006860-a3b8hyyr	2029	9	of	of	IN
cord-006860-a3b8hyyr	2029	10	factor	factor	NN
cord-006860-a3b8hyyr	2029	11	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	2029	12	,	,	,
cord-006860-a3b8hyyr	2029	13	possibly	possibly	RB
cord-006860-a3b8hyyr	2029	14	due	due	IN
cord-006860-a3b8hyyr	2029	15	to	to	IN
cord-006860-a3b8hyyr	2029	16	the	the	DT
cord-006860-a3b8hyyr	2029	17	absence	absence	NN
cord-006860-a3b8hyyr	2029	18	of	of	IN
cord-006860-a3b8hyyr	2029	19	soluble	soluble	JJ
cord-006860-a3b8hyyr	2029	20	HLA	HLA	NNP
cord-006860-a3b8hyyr	2029	21	-	-	HYPH
cord-006860-a3b8hyyr	2029	22	antigens	antigen	NNS
cord-006860-a3b8hyyr	2029	23	,	,	,
cord-006860-a3b8hyyr	2029	24	are	be	VBP
cord-006860-a3b8hyyr	2029	25	advantageous	advantageous	JJ
cord-006860-a3b8hyyr	2029	26	in	in	IN
cord-006860-a3b8hyyr	2029	27	patients	patient	NNS
cord-006860-a3b8hyyr	2029	28	disposed	dispose	VBN
cord-006860-a3b8hyyr	2029	29	to	to	IN
cord-006860-a3b8hyyr	2029	30	allergic	allergic	JJ
cord-006860-a3b8hyyr	2029	31	reactions	reaction	NNS
cord-006860-a3b8hyyr	2029	32	.	.	.
cord-006860-a3b8hyyr	2030	1	Introduction	introduction	NN
cord-006860-a3b8hyyr	2030	2	:	:	:
cord-006860-a3b8hyyr	2031	1	Antibody	antibody	NN
cord-006860-a3b8hyyr	2031	2	formation	formation	NN
cord-006860-a3b8hyyr	2031	3	against	against	IN
cord-006860-a3b8hyyr	2031	4	factor	factor	NN
cord-006860-a3b8hyyr	2031	5	(	(	-LRB-
cord-006860-a3b8hyyr	2031	6	F	F	NNP
cord-006860-a3b8hyyr	2031	7	)	)	-RRB-
cord-006860-a3b8hyyr	2031	8	VIII	VIII	NNP
cord-006860-a3b8hyyr	2031	9	remains	remain	VBZ
cord-006860-a3b8hyyr	2031	10	one	one	CD
cord-006860-a3b8hyyr	2031	11	of	of	IN
cord-006860-a3b8hyyr	2031	12	the	the	DT
cord-006860-a3b8hyyr	2031	13	most	most	RBS
cord-006860-a3b8hyyr	2031	14	severe	severe	JJ
cord-006860-a3b8hyyr	2031	15	complications	complication	NNS
cord-006860-a3b8hyyr	2031	16	of	of	IN
cord-006860-a3b8hyyr	2031	17	repeatedly	repeatedly	RB
cord-006860-a3b8hyyr	2031	18	transfused	transfuse	VBN
cord-006860-a3b8hyyr	2031	19	patients	patient	NNS
cord-006860-a3b8hyyr	2031	20	with	with	IN
cord-006860-a3b8hyyr	2031	21	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	2031	22	A.	a.	NN
cord-006860-a3b8hyyr	2032	1	As	as	IN
cord-006860-a3b8hyyr	2032	2	reported	report	VBN
cord-006860-a3b8hyyr	2032	3	previously	previously	RB
cord-006860-a3b8hyyr	2032	4	in	in	IN
cord-006860-a3b8hyyr	2032	5	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2032	6	study	study	NN
cord-006860-a3b8hyyr	2032	7	about	about	IN
cord-006860-a3b8hyyr	2032	8	the	the	DT
cord-006860-a3b8hyyr	2032	9	incidence	incidence	NN
cord-006860-a3b8hyyr	2032	10	of	of	IN
cord-006860-a3b8hyyr	2032	11	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2032	12	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2032	13	,	,	,
cord-006860-a3b8hyyr	2032	14	we	-PRON-	PRP
cord-006860-a3b8hyyr	2032	15	have	have	VBP
cord-006860-a3b8hyyr	2032	16	observed	observe	VBN
cord-006860-a3b8hyyr	2032	17	a	a	DT
cord-006860-a3b8hyyr	2032	18	high	high	JJ
cord-006860-a3b8hyyr	2032	19	incidence	incidence	NN
cord-006860-a3b8hyyr	2032	20	of	of	IN
cord-006860-a3b8hyyr	2032	21	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2032	22	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2032	23	among	among	IN
cord-006860-a3b8hyyr	2032	24	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2032	25	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	2032	26	A	a	DT
cord-006860-a3b8hyyr	2032	27	patients	patient	NNS
cord-006860-a3b8hyyr	2032	28	.	.	.
cord-006860-a3b8hyyr	2033	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	2033	2	is	be	VBZ
cord-006860-a3b8hyyr	2033	3	still	still	RB
cord-006860-a3b8hyyr	2033	4	not	not	RB
cord-006860-a3b8hyyr	2033	5	clear	clear	JJ
cord-006860-a3b8hyyr	2033	6	why	why	WRB
cord-006860-a3b8hyyr	2033	7	certain	certain	JJ
cord-006860-a3b8hyyr	2033	8	haemophiliacs	haemophiliac	NNS
cord-006860-a3b8hyyr	2033	9	develop	develop	VBP
cord-006860-a3b8hyyr	2033	10	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2033	11	and	and	CC
cord-006860-a3b8hyyr	2033	12	others	other	NNS
cord-006860-a3b8hyyr	2033	13	do	do	VBP
cord-006860-a3b8hyyr	2033	14	not	not	RB
cord-006860-a3b8hyyr	2033	15	.	.	.
cord-006860-a3b8hyyr	2034	1	A	a	DT
cord-006860-a3b8hyyr	2034	2	number	number	NN
cord-006860-a3b8hyyr	2034	3	of	of	IN
cord-006860-a3b8hyyr	2034	4	previous	previous	JJ
cord-006860-a3b8hyyr	2034	5	studies	study	NNS
cord-006860-a3b8hyyr	2034	6	suggest	suggest	VBP
cord-006860-a3b8hyyr	2034	7	that	that	IN
cord-006860-a3b8hyyr	2034	8	there	there	EX
cord-006860-a3b8hyyr	2034	9	is	be	VBZ
cord-006860-a3b8hyyr	2034	10	a	a	DT
cord-006860-a3b8hyyr	2034	11	genetic	genetic	JJ
cord-006860-a3b8hyyr	2034	12	predisposition	predisposition	NN
cord-006860-a3b8hyyr	2034	13	for	for	IN
cord-006860-a3b8hyyr	2034	14	the	the	DT
cord-006860-a3b8hyyr	2034	15	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2034	16	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2034	17	development	development	NN
cord-006860-a3b8hyyr	2034	18	.	.	.
cord-006860-a3b8hyyr	2035	1	Thus	thus	RB
cord-006860-a3b8hyyr	2035	2	,	,	,
cord-006860-a3b8hyyr	2035	3	the	the	DT
cord-006860-a3b8hyyr	2035	4	purpose	purpose	NN
cord-006860-a3b8hyyr	2035	5	of	of	IN
cord-006860-a3b8hyyr	2035	6	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2035	7	study	study	NN
cord-006860-a3b8hyyr	2035	8	was	be	VBD
cord-006860-a3b8hyyr	2035	9	to	to	TO
cord-006860-a3b8hyyr	2035	10	examine	examine	VB
cord-006860-a3b8hyyr	2035	11	,	,	,
cord-006860-a3b8hyyr	2035	12	if	if	IN
cord-006860-a3b8hyyr	2035	13	there	there	EX
cord-006860-a3b8hyyr	2035	14	is	be	VBZ
cord-006860-a3b8hyyr	2035	15	a	a	DT
cord-006860-a3b8hyyr	2035	16	correlation	correlation	NN
cord-006860-a3b8hyyr	2035	17	between	between	IN
cord-006860-a3b8hyyr	2035	18	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2035	19	antibody	antibody	NN
cord-006860-a3b8hyyr	2035	20	-	-	HYPH
cord-006860-a3b8hyyr	2035	21	formation	formation	NN
cord-006860-a3b8hyyr	2035	22	and	and	CC
cord-006860-a3b8hyyr	2035	23	genetically	genetically	RB
cord-006860-a3b8hyyr	2035	24	determined	determine	VBN
cord-006860-a3b8hyyr	2035	25	histoeompatibility	histoeompatibility	NN
cord-006860-a3b8hyyr	2035	26	antigen	antigen	NN
cord-006860-a3b8hyyr	2035	27	(	(	-LRB-
cord-006860-a3b8hyyr	2035	28	HLA	HLA	NNP
cord-006860-a3b8hyyr	2035	29	)	)	-RRB-
cord-006860-a3b8hyyr	2035	30	patterns	pattern	NNS
cord-006860-a3b8hyyr	2035	31	in	in	IN
cord-006860-a3b8hyyr	2035	32	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2035	33	haemophiliacs	haemophiliac	NNS
cord-006860-a3b8hyyr	2035	34	.	.	.
cord-006860-a3b8hyyr	2036	1	Patients	patient	NNS
cord-006860-a3b8hyyr	2036	2	and	and	CC
cord-006860-a3b8hyyr	2036	3	methods	method	NNS
cord-006860-a3b8hyyr	2036	4	:	:	:
cord-006860-a3b8hyyr	2036	5	HLA	hla	NN
cord-006860-a3b8hyyr	2036	6	-	-	HYPH
cord-006860-a3b8hyyr	2036	7	class	class	NN
cord-006860-a3b8hyyr	2036	8	I	i	NN
cord-006860-a3b8hyyr	2036	9	(	(	-LRB-
cord-006860-a3b8hyyr	2036	10	A	A	NNP
cord-006860-a3b8hyyr	2036	11	,	,	,
cord-006860-a3b8hyyr	2036	12	B	b	NN
cord-006860-a3b8hyyr	2036	13	,	,	,
cord-006860-a3b8hyyr	2036	14	C	C	NNP
cord-006860-a3b8hyyr	2036	15	)	)	-RRB-
cord-006860-a3b8hyyr	2036	16	and	and	CC
cord-006860-a3b8hyyr	2036	17	HLA	HLA	NNP
cord-006860-a3b8hyyr	2036	18	-	-	HYPH
cord-006860-a3b8hyyr	2036	19	class	class	NN
cord-006860-a3b8hyyr	2036	20	II	II	NNP
cord-006860-a3b8hyyr	2036	21	(	(	-LRB-
cord-006860-a3b8hyyr	2036	22	DR	DR	NNP
cord-006860-a3b8hyyr	2036	23	,	,	,
cord-006860-a3b8hyyr	2036	24	DQ	DQ	NNP
cord-006860-a3b8hyyr	2036	25	)	)	-RRB-
cord-006860-a3b8hyyr	2036	26	typing	typing	NN
cord-006860-a3b8hyyr	2036	27	was	be	VBD
cord-006860-a3b8hyyr	2036	28	carried	carry	VBN
cord-006860-a3b8hyyr	2036	29	out	out	RP
cord-006860-a3b8hyyr	2036	30	for	for	IN
cord-006860-a3b8hyyr	2036	31	51	51	CD
cord-006860-a3b8hyyr	2036	32	respectively	respectively	RB
cord-006860-a3b8hyyr	2036	33	44	44	CD
cord-006860-a3b8hyyr	2036	34	multi	multi	JJ
cord-006860-a3b8hyyr	2036	35	-	-	JJ
cord-006860-a3b8hyyr	2036	36	transfused	transfused	JJ
cord-006860-a3b8hyyr	2036	37	paediatric	paediatric	JJ
cord-006860-a3b8hyyr	2036	38	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	2037	1	A	a	DT
cord-006860-a3b8hyyr	2037	2	patients	patient	NNS
cord-006860-a3b8hyyr	2037	3	(	(	-LRB-
cord-006860-a3b8hyyr	2037	4	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2037	5	:	:	:
cord-006860-a3b8hyyr	2038	1	C	c	NN
cord-006860-a3b8hyyr	2038	2	activity	activity	NN
cord-006860-a3b8hyyr	2039	1	<	<	NNP
cord-006860-a3b8hyyr	2039	2	5	5	CD
cord-006860-a3b8hyyr	2039	3	%	%	NN
cord-006860-a3b8hyyr	2039	4	)	)	-RRB-
cord-006860-a3b8hyyr	2039	5	,	,	,
cord-006860-a3b8hyyr	2039	6	including	include	VBG
cord-006860-a3b8hyyr	2039	7	22	22	CD
cord-006860-a3b8hyyr	2039	8	who	who	WP
cord-006860-a3b8hyyr	2039	9	had	have	VBD
cord-006860-a3b8hyyr	2039	10	developed	develop	VBN
cord-006860-a3b8hyyr	2039	11	an	an	DT
cord-006860-a3b8hyyr	2039	12	antibody	antibody	NN
cord-006860-a3b8hyyr	2039	13	to	to	IN
cord-006860-a3b8hyyr	2039	14	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2040	1	:	:	:
cord-006860-a3b8hyyr	2040	2	19	19	CD
cord-006860-a3b8hyyr	2040	3	were	be	VBD
cord-006860-a3b8hyyr	2040	4	high	high	JJ
cord-006860-a3b8hyyr	2040	5	responders	responder	NNS
cord-006860-a3b8hyyr	2040	6	(	(	-LRB-
cord-006860-a3b8hyyr	2040	7	>	>	NFP
cord-006860-a3b8hyyr	2040	8	5	5	CD
cord-006860-a3b8hyyr	2040	9	BU	BU	NNP
cord-006860-a3b8hyyr	2040	10	)	)	-RRB-
cord-006860-a3b8hyyr	2040	11	,	,	,
cord-006860-a3b8hyyr	2040	12	3	3	CD
cord-006860-a3b8hyyr	2040	13	were	be	VBD
cord-006860-a3b8hyyr	2040	14	low	low	JJ
cord-006860-a3b8hyyr	2040	15	responders	responder	NNS
cord-006860-a3b8hyyr	2040	16	(	(	-LRB-
cord-006860-a3b8hyyr	2040	17	<	<	XX
cord-006860-a3b8hyyr	2040	18	5	5	CD
cord-006860-a3b8hyyr	2040	19	BU	BU	NNP
cord-006860-a3b8hyyr	2040	20	)	)	-RRB-
cord-006860-a3b8hyyr	2040	21	.	.	.
cord-006860-a3b8hyyr	2041	1	HLA	HLA	NNP
cord-006860-a3b8hyyr	2041	2	-	-	HYPH
cord-006860-a3b8hyyr	2041	3	typing	typing	NN
cord-006860-a3b8hyyr	2041	4	has	have	VBZ
cord-006860-a3b8hyyr	2041	5	been	be	VBN
cord-006860-a3b8hyyr	2041	6	performed	perform	VBN
cord-006860-a3b8hyyr	2041	7	by	by	IN
cord-006860-a3b8hyyr	2041	8	a	a	DT
cord-006860-a3b8hyyr	2041	9	standurcl	standurcl	JJ
cord-006860-a3b8hyyr	2041	10	two	two	CD
cord-006860-a3b8hyyr	2041	11	-	-	HYPH
cord-006860-a3b8hyyr	2041	12	stage	stage	NN
cord-006860-a3b8hyyr	2041	13	microlymphoc~.ftotoxicity	microlymphoc~.ftotoxicity	CD
cord-006860-a3b8hyyr	2041	14	procedure	procedure	NN
cord-006860-a3b8hyyr	2041	15	(	(	-LRB-
cord-006860-a3b8hyyr	2041	16	DRK	DRK	NNP
cord-006860-a3b8hyyr	2041	17	Frankfurt	Frankfurt	NNP
cord-006860-a3b8hyyr	2041	18	)	)	-RRB-
cord-006860-a3b8hyyr	2041	19	using	use	VBG
cord-006860-a3b8hyyr	2041	20	antisera	antisera	NNP
cord-006860-a3b8hyyr	2041	21	with	with	IN
cord-006860-a3b8hyyr	2041	22	defiend	defiend	NNP
cord-006860-a3b8hyyr	2041	23	HLA	HLA	NNP
cord-006860-a3b8hyyr	2041	24	-	-	HYPH
cord-006860-a3b8hyyr	2041	25	specifity	specifity	NNP
cord-006860-a3b8hyyr	2041	26	(	(	-LRB-
cord-006860-a3b8hyyr	2041	27	Biotest	Biotest	NNP
cord-006860-a3b8hyyr	2041	28	Diagnostica	Diagnostica	NNP
cord-006860-a3b8hyyr	2041	29	)	)	-RRB-
cord-006860-a3b8hyyr	2041	30	.	.	.
cord-006860-a3b8hyyr	2042	1	Results	result	NNS
cord-006860-a3b8hyyr	2042	2	:	:	:
cord-006860-a3b8hyyr	2043	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2043	2	found	find	VBD
cord-006860-a3b8hyyr	2043	3	an	an	DT
cord-006860-a3b8hyyr	2043	4	under	under	NN
cord-006860-a3b8hyyr	2043	5	-	-	HYPH
cord-006860-a3b8hyyr	2043	6	representation	representation	NN
cord-006860-a3b8hyyr	2043	7	of	of	IN
cord-006860-a3b8hyyr	2043	8	HLA	HLA	NNP
cord-006860-a3b8hyyr	2043	9	-	-	HYPH
cord-006860-a3b8hyyr	2043	10	A2	A2	NNP
cord-006860-a3b8hyyr	2043	11	in	in	IN
cord-006860-a3b8hyyr	2043	12	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2043	13	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2043	14	patients	patient	NNS
cord-006860-a3b8hyyr	2043	15	when	when	WRB
cord-006860-a3b8hyyr	2043	16	compared	compare	VBN
cord-006860-a3b8hyyr	2043	17	with	with	IN
cord-006860-a3b8hyyr	2043	18	the	the	DT
cord-006860-a3b8hyyr	2043	19	subgroup	subgroup	NN
cord-006860-a3b8hyyr	2043	20	without	without	IN
cord-006860-a3b8hyyr	2043	21	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2043	22	.	.	.
cord-006860-a3b8hyyr	2044	1	In	in	IN
cord-006860-a3b8hyyr	2044	2	regard	regard	NN
cord-006860-a3b8hyyr	2044	3	to	to	IN
cord-006860-a3b8hyyr	2044	4	the	the	DT
cord-006860-a3b8hyyr	2044	5	HLA	HLA	NNP
cord-006860-a3b8hyyr	2044	6	-	-	HYPH
cord-006860-a3b8hyyr	2044	7	B	B	NNP
cord-006860-a3b8hyyr	2044	8	and	and	CC
cord-006860-a3b8hyyr	2044	9	HLA	HLA	NNP
cord-006860-a3b8hyyr	2044	10	-	-	HYPH
cord-006860-a3b8hyyr	2044	11	C	C	NNP
cord-006860-a3b8hyyr	2044	12	antigen	antigen	NN
cord-006860-a3b8hyyr	2044	13	frequencies	frequency	NNS
cord-006860-a3b8hyyr	2044	14	there	there	EX
cord-006860-a3b8hyyr	2044	15	are	be	VBP
cord-006860-a3b8hyyr	2044	16	no	no	DT
cord-006860-a3b8hyyr	2044	17	apparent	apparent	JJ
cord-006860-a3b8hyyr	2044	18	differences	difference	NNS
cord-006860-a3b8hyyr	2044	19	between	between	IN
cord-006860-a3b8hyyr	2044	20	the	the	DT
cord-006860-a3b8hyyr	2044	21	groups	group	NNS
cord-006860-a3b8hyyr	2044	22	.	.	.
cord-006860-a3b8hyyr	2045	1	Among	among	IN
cord-006860-a3b8hyyr	2045	2	the	the	DT
cord-006860-a3b8hyyr	2045	3	class	class	NN
cord-006860-a3b8hyyr	2045	4	II	ii	CD
cord-006860-a3b8hyyr	2045	5	antigens	antigen	NNS
cord-006860-a3b8hyyr	2045	6	there	there	EX
cord-006860-a3b8hyyr	2045	7	were	be	VBD
cord-006860-a3b8hyyr	2045	8	higher	high	JJR
cord-006860-a3b8hyyr	2045	9	frequencies	frequency	NNS
cord-006860-a3b8hyyr	2045	10	of	of	IN
cord-006860-a3b8hyyr	2045	11	DR1	dr1	NN
cord-006860-a3b8hyyr	2045	12	,	,	,
cord-006860-a3b8hyyr	2045	13	DRw52	DRw52	NNS
cord-006860-a3b8hyyr	2045	14	and	and	CC
cord-006860-a3b8hyyr	2045	15	DQwl	DQwl	NNP
cord-006860-a3b8hyyr	2045	16	in	in	IN
cord-006860-a3b8hyyr	2045	17	the	the	DT
cord-006860-a3b8hyyr	2045	18	non	non	JJ
cord-006860-a3b8hyyr	2045	19	-	-	JJ
cord-006860-a3b8hyyr	2045	20	inhibitor	inhibitor	JJ
cord-006860-a3b8hyyr	2045	21	group	group	NN
cord-006860-a3b8hyyr	2045	22	.	.	.
cord-006860-a3b8hyyr	2046	1	However	however	RB
cord-006860-a3b8hyyr	2046	2	,	,	,
cord-006860-a3b8hyyr	2046	3	the	the	DT
cord-006860-a3b8hyyr	2046	4	reduction	reduction	NN
cord-006860-a3b8hyyr	2046	5	in	in	IN
cord-006860-a3b8hyyr	2046	6	HLA	HLA	NNP
cord-006860-a3b8hyyr	2046	7	-	-	HYPH
cord-006860-a3b8hyyr	2046	8	A1	A1	NNP
cord-006860-a3b8hyyr	2046	9	,	,	,
cord-006860-a3b8hyyr	2046	10	HLA	HLA	NNP
cord-006860-a3b8hyyr	2046	11	-	-	HYPH
cord-006860-a3b8hyyr	2046	12	Cw5	Cw5	NNP
cord-006860-a3b8hyyr	2046	13	,	,	,
cord-006860-a3b8hyyr	2046	14	HLA	HLA	NNP
cord-006860-a3b8hyyr	2046	15	-	-	HYPH
cord-006860-a3b8hyyr	2046	16	DQw3	DQw3	NNP
cord-006860-a3b8hyyr	2046	17	respectively	respectively	RB
cord-006860-a3b8hyyr	2046	18	HLA	HLA	NNP
cord-006860-a3b8hyyr	2046	19	-	-	HYPH
cord-006860-a3b8hyyr	2046	20	DR4	dr4	NN
cord-006860-a3b8hyyr	2046	21	frequency	frequency	NN
cord-006860-a3b8hyyr	2046	22	for	for	IN
cord-006860-a3b8hyyr	2046	23	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2046	24	patients	patient	NNS
cord-006860-a3b8hyyr	2046	25	as	as	IN
cord-006860-a3b8hyyr	2046	26	reported	report	VBN
cord-006860-a3b8hyyr	2046	27	previously	previously	RB
cord-006860-a3b8hyyr	2046	28	could	could	MD
cord-006860-a3b8hyyr	2046	29	not	not	RB
cord-006860-a3b8hyyr	2046	30	be	be	VB
cord-006860-a3b8hyyr	2046	31	confirmed	confirm	VBN
cord-006860-a3b8hyyr	2046	32	in	in	IN
cord-006860-a3b8hyyr	2046	33	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2046	34	study	study	NN
cord-006860-a3b8hyyr	2046	35	.	.	.
cord-006860-a3b8hyyr	2047	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	2047	2	:	:	:
cord-006860-a3b8hyyr	2048	1	So	so	RB
cord-006860-a3b8hyyr	2048	2	far	far	RB
cord-006860-a3b8hyyr	2048	3	it	-PRON-	PRP
cord-006860-a3b8hyyr	2048	4	remains	remain	VBZ
cord-006860-a3b8hyyr	2048	5	unclear	unclear	JJ
cord-006860-a3b8hyyr	2048	6	if	if	IN
cord-006860-a3b8hyyr	2048	7	there	there	EX
cord-006860-a3b8hyyr	2048	8	is	be	VBZ
cord-006860-a3b8hyyr	2048	9	a	a	DT
cord-006860-a3b8hyyr	2048	10	significant	significant	JJ
cord-006860-a3b8hyyr	2048	11	association	association	NN
cord-006860-a3b8hyyr	2048	12	of	of	IN
cord-006860-a3b8hyyr	2048	13	a	a	DT
cord-006860-a3b8hyyr	2048	14	certain	certain	JJ
cord-006860-a3b8hyyr	2048	15	HLA	HLA	NNP
cord-006860-a3b8hyyr	2048	16	allels	allel	NNS
cord-006860-a3b8hyyr	2048	17	with	with	IN
cord-006860-a3b8hyyr	2048	18	the	the	DT
cord-006860-a3b8hyyr	2048	19	development	development	NN
cord-006860-a3b8hyyr	2048	20	of	of	IN
cord-006860-a3b8hyyr	2048	21	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2048	22	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2048	23	.	.	.
cord-006860-a3b8hyyr	2049	1	Recombinant	recombinant	JJ
cord-006860-a3b8hyyr	2049	2	factor	factor	NN
cord-006860-a3b8hyyr	2049	3	SQ	SQ	NNP
cord-006860-a3b8hyyr	2050	1	(	(	-LRB-
cord-006860-a3b8hyyr	2050	2	r	r	NN
cord-006860-a3b8hyyr	2050	3	-	-	HYPH
cord-006860-a3b8hyyr	2050	4	Viii	Viii	NNP
cord-006860-a3b8hyyr	2050	5	SQ	SQ	NNP
cord-006860-a3b8hyyr	2050	6	,	,	,
cord-006860-a3b8hyyr	2050	7	Pharmacia	Pharmacia	NNP
cord-006860-a3b8hyyr	2050	8	)	)	-RRB-
cord-006860-a3b8hyyr	2050	9	is	be	VBZ
cord-006860-a3b8hyyr	2050	10	a	a	DT
cord-006860-a3b8hyyr	2050	11	B	b	NN
cord-006860-a3b8hyyr	2050	12	-	-	HYPH
cord-006860-a3b8hyyr	2050	13	domain	domain	NN
cord-006860-a3b8hyyr	2050	14	-	-	HYPH
cord-006860-a3b8hyyr	2050	15	deleted	delete	VBN
cord-006860-a3b8hyyr	2050	16	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	2050	17	factor	factor	NN
cord-006860-a3b8hyyr	2050	18	VIII	VIII	NNP
cord-006860-a3b8hyyr	2050	19	.	.	.
cord-006860-a3b8hyyr	2051	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	2051	2	is	be	VBZ
cord-006860-a3b8hyyr	2051	3	formulated	formulate	VBN
cord-006860-a3b8hyyr	2051	4	without	without	IN
cord-006860-a3b8hyyr	2051	5	albumin	albumin	NN
cord-006860-a3b8hyyr	2051	6	(	(	-LRB-
cord-006860-a3b8hyyr	2051	7	HSA	HSA	NNP
cord-006860-a3b8hyyr	2051	8	)	)	-RRB-
cord-006860-a3b8hyyr	2051	9	.	.	.
cord-006860-a3b8hyyr	2052	1	The	the	DT
cord-006860-a3b8hyyr	2052	2	product	product	NN
cord-006860-a3b8hyyr	2052	3	has	have	VBZ
cord-006860-a3b8hyyr	2052	4	been	be	VBN
cord-006860-a3b8hyyr	2052	5	shown	show	VBN
cord-006860-a3b8hyyr	2052	6	to	to	TO
cord-006860-a3b8hyyr	2052	7	have	have	VB
cord-006860-a3b8hyyr	2052	8	in	in	IN
cord-006860-a3b8hyyr	2052	9	vitro	vitro	FW
cord-006860-a3b8hyyr	2052	10	and	and	CC
cord-006860-a3b8hyyr	2052	11	in	in	IN
cord-006860-a3b8hyyr	2052	12	vivo	vivo	JJ
cord-006860-a3b8hyyr	2052	13	biochemical	biochemical	JJ
cord-006860-a3b8hyyr	2052	14	characteristics	characteristic	NNS
cord-006860-a3b8hyyr	2052	15	similar	similar	JJ
cord-006860-a3b8hyyr	2052	16	to	to	IN
cord-006860-a3b8hyyr	2052	17	a	a	DT
cord-006860-a3b8hyyr	2052	18	plasma	plasma	NN
cord-006860-a3b8hyyr	2052	19	derived	derive	VBN
cord-006860-a3b8hyyr	2052	20	full	full	JJ
cord-006860-a3b8hyyr	2052	21	-	-	HYPH
cord-006860-a3b8hyyr	2052	22	length	length	NN
cord-006860-a3b8hyyr	2052	23	protein	protein	NN
cord-006860-a3b8hyyr	2052	24	(	(	-LRB-
cord-006860-a3b8hyyr	2052	25	p	p	NN
cord-006860-a3b8hyyr	2052	26	-	-	:
cord-006860-a3b8hyyr	2052	27	Viii	Viii	NNP
cord-006860-a3b8hyyr	2052	28	)	)	-RRB-
cord-006860-a3b8hyyr	2052	29	.	.	.
cord-006860-a3b8hyyr	2053	1	The	the	DT
cord-006860-a3b8hyyr	2053	2	international	international	JJ
cord-006860-a3b8hyyr	2053	3	clinical	clinical	JJ
cord-006860-a3b8hyyr	2053	4	trial	trial	NN
cord-006860-a3b8hyyr	2053	5	programme	programme	NN
cord-006860-a3b8hyyr	2053	6	was	be	VBD
cord-006860-a3b8hyyr	2053	7	initiated	initiate	VBN
cord-006860-a3b8hyyr	2053	8	in	in	IN
cord-006860-a3b8hyyr	2053	9	March	March	NNP
cord-006860-a3b8hyyr	2053	10	1993	1993	CD
cord-006860-a3b8hyyr	2053	11	.	.	.
cord-006860-a3b8hyyr	2054	1	Pharmacokinetic	pharmacokinetic	JJ
cord-006860-a3b8hyyr	2054	2	studies	study	NNS
cord-006860-a3b8hyyr	2054	3	have	have	VBP
cord-006860-a3b8hyyr	2054	4	shown	show	VBN
cord-006860-a3b8hyyr	2054	5	that	that	IN
cord-006860-a3b8hyyr	2054	6	the	the	DT
cord-006860-a3b8hyyr	2054	7	B	b	NN
cord-006860-a3b8hyyr	2054	8	-	-	HYPH
cord-006860-a3b8hyyr	2054	9	deleted	delete	VBN
cord-006860-a3b8hyyr	2054	10	r	r	NN
cord-006860-a3b8hyyr	2054	11	-	-	HYPH
cord-006860-a3b8hyyr	2054	12	VIII	VIII	NNP
cord-006860-a3b8hyyr	2054	13	SQ	SQ	NNP
cord-006860-a3b8hyyr	2054	14	should	should	MD
cord-006860-a3b8hyyr	2054	15	be	be	VB
cord-006860-a3b8hyyr	2054	16	given	give	VBN
cord-006860-a3b8hyyr	2054	17	according	accord	VBG
cord-006860-a3b8hyyr	2054	18	to	to	IN
cord-006860-a3b8hyyr	2054	19	the	the	DT
cord-006860-a3b8hyyr	2054	20	same	same	JJ
cord-006860-a3b8hyyr	2054	21	dosage	dosage	NN
cord-006860-a3b8hyyr	2054	22	principles	principle	NNS
cord-006860-a3b8hyyr	2054	23	as	as	IN
cord-006860-a3b8hyyr	2054	24	a	a	DT
cord-006860-a3b8hyyr	2054	25	full	full	JJ
cord-006860-a3b8hyyr	2054	26	length	length	NN
cord-006860-a3b8hyyr	2054	27	p	p	NN
cord-006860-a3b8hyyr	2054	28	-	-	HYPH
cord-006860-a3b8hyyr	2054	29	VIII	VIII	NNP
cord-006860-a3b8hyyr	2054	30	.	.	.
cord-006860-a3b8hyyr	2055	1	At	at	IN
cord-006860-a3b8hyyr	2055	2	present	present	NN
cord-006860-a3b8hyyr	2055	3	,	,	,
cord-006860-a3b8hyyr	2055	4	the	the	DT
cord-006860-a3b8hyyr	2055	5	product	product	NN
cord-006860-a3b8hyyr	2055	6	is	be	VBZ
cord-006860-a3b8hyyr	2055	7	being	be	VBG
cord-006860-a3b8hyyr	2055	8	tested	test	VBN
cord-006860-a3b8hyyr	2055	9	in	in	IN
cord-006860-a3b8hyyr	2055	10	previously	previously	RB
cord-006860-a3b8hyyr	2055	11	treated	treat	VBN
cord-006860-a3b8hyyr	2055	12	patients	patient	NNS
cord-006860-a3b8hyyr	2055	13	(	(	-LRB-
cord-006860-a3b8hyyr	2055	14	PTPs	ptp	NNS
cord-006860-a3b8hyyr	2055	15	)	)	-RRB-
cord-006860-a3b8hyyr	2055	16	and	and	CC
cord-006860-a3b8hyyr	2055	17	untreated	untreated	JJ
cord-006860-a3b8hyyr	2055	18	patients	patient	NNS
cord-006860-a3b8hyyr	2055	19	(	(	-LRB-
cord-006860-a3b8hyyr	2055	20	PUPs	pup	NNS
cord-006860-a3b8hyyr	2055	21	)	)	-RRB-
cord-006860-a3b8hyyr	2055	22	with	with	IN
cord-006860-a3b8hyyr	2055	23	severe	severe	JJ
cord-006860-a3b8hyyr	2055	24	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	2055	25	A	a	NN
cord-006860-a3b8hyyr	2055	26	(	(	-LRB-
cord-006860-a3b8hyyr	2055	27	VIII	VIII	NNP
cord-006860-a3b8hyyr	2055	28	:	:	:
cord-006860-a3b8hyyr	2055	29	C	C	NNP
cord-006860-a3b8hyyr	2055	30	<	<	XX
cord-006860-a3b8hyyr	2055	31	2	2	CD
cord-006860-a3b8hyyr	2055	32	%	%	NN
cord-006860-a3b8hyyr	2055	33	)	)	-RRB-
cord-006860-a3b8hyyr	2055	34	,	,	,
cord-006860-a3b8hyyr	2055	35	both	both	CC
cord-006860-a3b8hyyr	2055	36	during	during	IN
cord-006860-a3b8hyyr	2055	37	long	long	JJ
cord-006860-a3b8hyyr	2055	38	-	-	HYPH
cord-006860-a3b8hyyr	2055	39	term	term	NN
cord-006860-a3b8hyyr	2055	40	treatment	treatment	NN
cord-006860-a3b8hyyr	2055	41	(	(	-LRB-
cord-006860-a3b8hyyr	2055	42	on	on	IN
cord-006860-a3b8hyyr	2055	43	demand	demand	NN
cord-006860-a3b8hyyr	2055	44	therapy	therapy	NN
cord-006860-a3b8hyyr	2055	45	or	or	CC
cord-006860-a3b8hyyr	2055	46	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2055	47	)	)	-RRB-
cord-006860-a3b8hyyr	2055	48	as	as	RB
cord-006860-a3b8hyyr	2055	49	well	well	RB
cord-006860-a3b8hyyr	2055	50	as	as	IN
cord-006860-a3b8hyyr	2055	51	during	during	IN
cord-006860-a3b8hyyr	2055	52	surgery	surgery	NN
cord-006860-a3b8hyyr	2055	53	.	.	.
cord-006860-a3b8hyyr	2056	1	The	the	DT
cord-006860-a3b8hyyr	2056	2	long	long	JJ
cord-006860-a3b8hyyr	2056	3	-	-	HYPH
cord-006860-a3b8hyyr	2056	4	term	term	NN
cord-006860-a3b8hyyr	2056	5	study	study	NN
cord-006860-a3b8hyyr	2056	6	in	in	IN
cord-006860-a3b8hyyr	2056	7	previously	previously	RB
cord-006860-a3b8hyyr	2056	8	treated	treat	VBN
cord-006860-a3b8hyyr	2056	9	patients	patient	NNS
cord-006860-a3b8hyyr	2056	10	in	in	IN
cord-006860-a3b8hyyr	2056	11	Germany	Germany	NNP
cord-006860-a3b8hyyr	2056	12	was	be	VBD
cord-006860-a3b8hyyr	2056	13	started	start	VBN
cord-006860-a3b8hyyr	2056	14	in	in	IN
cord-006860-a3b8hyyr	2056	15	January	January	NNP
cord-006860-a3b8hyyr	2056	16	1994	1994	CD
cord-006860-a3b8hyyr	2056	17	.	.	.
cord-006860-a3b8hyyr	2057	1	Thirteen	thirteen	CD
cord-006860-a3b8hyyr	2057	2	patients	patient	NNS
cord-006860-a3b8hyyr	2057	3	have	have	VBP
cord-006860-a3b8hyyr	2057	4	been	be	VBN
cord-006860-a3b8hyyr	2057	5	included	include	VBN
cord-006860-a3b8hyyr	2057	6	in	in	IN
cord-006860-a3b8hyyr	2057	7	8	8	CD
cord-006860-a3b8hyyr	2057	8	centers	center	NNS
cord-006860-a3b8hyyr	2057	9	.	.	.
cord-006860-a3b8hyyr	2058	1	All	all	DT
cord-006860-a3b8hyyr	2058	2	patients	patient	NNS
cord-006860-a3b8hyyr	2058	3	are	be	VBP
cord-006860-a3b8hyyr	2058	4	still	still	RB
cord-006860-a3b8hyyr	2058	5	on	on	IN
cord-006860-a3b8hyyr	2058	6	treatment	treatment	NN
cord-006860-a3b8hyyr	2058	7	with	with	IN
cord-006860-a3b8hyyr	2058	8	r	r	NN
cord-006860-a3b8hyyr	2058	9	-	-	HYPH
cord-006860-a3b8hyyr	2058	10	VIII	VIII	NNP
cord-006860-a3b8hyyr	2058	11	SQ	SQ	NNP
cord-006860-a3b8hyyr	2058	12	,	,	,
cord-006860-a3b8hyyr	2058	13	most	most	JJS
cord-006860-a3b8hyyr	2058	14	of	of	IN
cord-006860-a3b8hyyr	2058	15	them	-PRON-	PRP
cord-006860-a3b8hyyr	2058	16	receiving	receive	VBG
cord-006860-a3b8hyyr	2058	17	prophylactic	prophylactic	JJ
cord-006860-a3b8hyyr	2058	18	treatment	treatment	NN
cord-006860-a3b8hyyr	2058	19	.	.	.
cord-006860-a3b8hyyr	2059	1	Global	global	JJ
cord-006860-a3b8hyyr	2059	2	treatment	treatment	NN
cord-006860-a3b8hyyr	2059	3	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2059	4	has	have	VBZ
cord-006860-a3b8hyyr	2059	5	in	in	IN
cord-006860-a3b8hyyr	2059	6	general	general	JJ
cord-006860-a3b8hyyr	2059	7	been	be	VBN
cord-006860-a3b8hyyr	2059	8	considered	consider	VBN
cord-006860-a3b8hyyr	2059	9	excellent	excellent	JJ
cord-006860-a3b8hyyr	2059	10	or	or	CC
cord-006860-a3b8hyyr	2059	11	good	good	JJ
cord-006860-a3b8hyyr	2059	12	.	.	.
cord-006860-a3b8hyyr	2060	1	No	no	DT
cord-006860-a3b8hyyr	2060	2	serious	serious	JJ
cord-006860-a3b8hyyr	2060	3	clinical	clinical	JJ
cord-006860-a3b8hyyr	2060	4	adverse	adverse	JJ
cord-006860-a3b8hyyr	2060	5	events	event	NNS
cord-006860-a3b8hyyr	2060	6	related	relate	VBN
cord-006860-a3b8hyyr	2060	7	to	to	IN
cord-006860-a3b8hyyr	2060	8	the	the	DT
cord-006860-a3b8hyyr	2060	9	study	study	NN
cord-006860-a3b8hyyr	2060	10	product	product	NN
cord-006860-a3b8hyyr	2060	11	have	have	VBP
cord-006860-a3b8hyyr	2060	12	been	be	VBN
cord-006860-a3b8hyyr	2060	13	reported	report	VBN
cord-006860-a3b8hyyr	2060	14	,	,	,
cord-006860-a3b8hyyr	2060	15	nor	nor	CC
cord-006860-a3b8hyyr	2060	16	have	have	VBP
cord-006860-a3b8hyyr	2060	17	any	any	DT
cord-006860-a3b8hyyr	2060	18	inhibiting	inhibit	VBG
cord-006860-a3b8hyyr	2060	19	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2060	20	to	to	TO
cord-006860-a3b8hyyr	2060	21	factor	factor	VB
cord-006860-a3b8hyyr	2060	22	VIII	VIII	NNP
cord-006860-a3b8hyyr	2060	23	or	or	CC
cord-006860-a3b8hyyr	2060	24	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2060	25	to	to	IN
cord-006860-a3b8hyyr	2060	26	mouse	mouse	NN
cord-006860-a3b8hyyr	2060	27	-	-	:
cord-006860-a3b8hyyr	2060	28	lgG	lgG	NNP
cord-006860-a3b8hyyr	2060	29	or	or	CC
cord-006860-a3b8hyyr	2060	30	CHO	CHO	NNP
cord-006860-a3b8hyyr	2060	31	-	-	HYPH
cord-006860-a3b8hyyr	2060	32	cell	cell	NN
cord-006860-a3b8hyyr	2060	33	components	component	NNS
cord-006860-a3b8hyyr	2060	34	developed	develop	VBN
cord-006860-a3b8hyyr	2060	35	in	in	IN
cord-006860-a3b8hyyr	2060	36	the	the	DT
cord-006860-a3b8hyyr	2060	37	patients	patient	NNS
cord-006860-a3b8hyyr	2060	38	.	.	.
cord-006860-a3b8hyyr	2061	1	Further	further	JJ
cord-006860-a3b8hyyr	2061	2	results	result	NNS
cord-006860-a3b8hyyr	2061	3	such	such	JJ
cord-006860-a3b8hyyr	2061	4	as	as	IN
cord-006860-a3b8hyyr	2061	5	data	datum	NNS
cord-006860-a3b8hyyr	2061	6	on	on	IN
cord-006860-a3b8hyyr	2061	7	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2061	8	,	,	,
cord-006860-a3b8hyyr	2061	9	half	half	JJ
cord-006860-a3b8hyyr	2061	10	-	-	HYPH
cord-006860-a3b8hyyr	2061	11	life	life	NN
cord-006860-a3b8hyyr	2061	12	,	,	,
cord-006860-a3b8hyyr	2061	13	recovery	recovery	NN
cord-006860-a3b8hyyr	2061	14	and	and	CC
cord-006860-a3b8hyyr	2061	15	safety	safety	NN
cord-006860-a3b8hyyr	2061	16	will	will	MD
cord-006860-a3b8hyyr	2061	17	be	be	VB
cord-006860-a3b8hyyr	2061	18	presented	present	VBN
cord-006860-a3b8hyyr	2061	19	in	in	IN
cord-006860-a3b8hyyr	2061	20	detail	detail	NN
cord-006860-a3b8hyyr	2061	21	at	at	IN
cord-006860-a3b8hyyr	2061	22	the	the	DT
cord-006860-a3b8hyyr	2061	23	meeting	meeting	NN
cord-006860-a3b8hyyr	2061	24	.	.	.
cord-006860-a3b8hyyr	2062	1	Nowadays	nowadays	RB
cord-006860-a3b8hyyr	2062	2	it	-PRON-	PRP
cord-006860-a3b8hyyr	2062	3	is	be	VBZ
cord-006860-a3b8hyyr	2062	4	not	not	RB
cord-006860-a3b8hyyr	2062	5	sufficient	sufficient	JJ
cord-006860-a3b8hyyr	2062	6	to	to	TO
cord-006860-a3b8hyyr	2062	7	regard	regard	VB
cord-006860-a3b8hyyr	2062	8	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2062	9	only	only	RB
cord-006860-a3b8hyyr	2062	10	as	as	IN
cord-006860-a3b8hyyr	2062	11	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	2062	12	diafhesis	diafhesis	NN
cord-006860-a3b8hyyr	2062	13	of	of	IN
cord-006860-a3b8hyyr	2062	14	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2062	15	genesis	genesis	NN
cord-006860-a3b8hyyr	2062	16	,	,	,
cord-006860-a3b8hyyr	2062	17	caused	cause	VBN
cord-006860-a3b8hyyr	2062	18	by	by	IN
cord-006860-a3b8hyyr	2062	19	deficiency	deficiency	NN
cord-006860-a3b8hyyr	2062	20	or	or	CC
cord-006860-a3b8hyyr	2062	21	molecular	molecular	JJ
cord-006860-a3b8hyyr	2062	22	anomalies	anomaly	NNS
cord-006860-a3b8hyyr	2062	23	of	of	IN
cord-006860-a3b8hyyr	2062	24	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2062	25	factor	factor	NN
cord-006860-a3b8hyyr	2062	26	,	,	,
cord-006860-a3b8hyyr	2062	27	without	without	IN
cord-006860-a3b8hyyr	2062	28	taking	take	VBG
cord-006860-a3b8hyyr	2062	29	into	into	IN
cord-006860-a3b8hyyr	2062	30	account	account	NN
cord-006860-a3b8hyyr	2062	31	the	the	DT
cord-006860-a3b8hyyr	2062	32	immunity	immunity	NN
cord-006860-a3b8hyyr	2062	33	state	state	NN
cord-006860-a3b8hyyr	2062	34	.	.	.
cord-006860-a3b8hyyr	2063	1	On	on	IN
cord-006860-a3b8hyyr	2063	2	examination	examination	NN
cord-006860-a3b8hyyr	2063	3	of	of	IN
cord-006860-a3b8hyyr	2063	4	125	125	CD
cord-006860-a3b8hyyr	2063	5	patients	patient	NNS
cord-006860-a3b8hyyr	2063	6	(	(	-LRB-
cord-006860-a3b8hyyr	2063	7	pts	pts	NN
cord-006860-a3b8hyyr	2063	8	)	)	-RRB-
cord-006860-a3b8hyyr	2063	9	(	(	-LRB-
cord-006860-a3b8hyyr	2063	10	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2063	11	A	a	DT
cord-006860-a3b8hyyr	2063	12	--110	--110	NNP
cord-006860-a3b8hyyr	2063	13	pts	pts	NN
cord-006860-a3b8hyyr	2063	14	,	,	,
cord-006860-a3b8hyyr	2063	15	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2063	16	B	b	NN
cord-006860-a3b8hyyr	2063	17	--11	--11	NNP
cord-006860-a3b8hyyr	2063	18	pts	pts	NNP
cord-006860-a3b8hyyr	2063	19	,	,	,
cord-006860-a3b8hyyr	2063	20	Willebrandt	Willebrandt	NNP
cord-006860-a3b8hyyr	2063	21	's	's	POS
cord-006860-a3b8hyyr	2063	22	disease	disease	NN
cord-006860-a3b8hyyr	2063	23	u	u	NNP
cord-006860-a3b8hyyr	2063	24	4	4	CD
cord-006860-a3b8hyyr	2063	25	pfs	pfs	NNP
cord-006860-a3b8hyyr	2063	26	)	)	-RRB-
cord-006860-a3b8hyyr	2064	1	the	the	DT
cord-006860-a3b8hyyr	2064	2	development	development	NN
cord-006860-a3b8hyyr	2064	3	of	of	IN
cord-006860-a3b8hyyr	2064	4	immune	immune	JJ
cord-006860-a3b8hyyr	2064	5	complications	complication	NNS
cord-006860-a3b8hyyr	2064	6	was	be	VBD
cord-006860-a3b8hyyr	2064	7	revealed	reveal	VBN
cord-006860-a3b8hyyr	2064	8	in	in	IN
cord-006860-a3b8hyyr	2064	9	34.4	34.4	CD
cord-006860-a3b8hyyr	2064	10	%	%	NN
cord-006860-a3b8hyyr	2064	11	.	.	.
cord-006860-a3b8hyyr	2065	1	Chronic	chronic	JJ
cord-006860-a3b8hyyr	2065	2	persistent	persistent	JJ
cord-006860-a3b8hyyr	2065	3	hepatitis	hepatitis	NN
cord-006860-a3b8hyyr	2065	4	(	(	-LRB-
cord-006860-a3b8hyyr	2065	5	3.2	3.2	CD
cord-006860-a3b8hyyr	2065	6	%	%	NN
cord-006860-a3b8hyyr	2065	7	)	)	-RRB-
cord-006860-a3b8hyyr	2065	8	,	,	,
cord-006860-a3b8hyyr	2065	9	chronic	chronic	JJ
cord-006860-a3b8hyyr	2065	10	active	active	JJ
cord-006860-a3b8hyyr	2065	11	hepatitis	hepatitis	NN
cord-006860-a3b8hyyr	2065	12	(	(	-LRB-
cord-006860-a3b8hyyr	2065	13	3.2	3.2	CD
cord-006860-a3b8hyyr	2065	14	%	%	NN
cord-006860-a3b8hyyr	2065	15	)	)	-RRB-
cord-006860-a3b8hyyr	2065	16	,	,	,
cord-006860-a3b8hyyr	2065	17	herpes	herpes	NN
cord-006860-a3b8hyyr	2065	18	simplex	simplex	NN
cord-006860-a3b8hyyr	2065	19	(	(	-LRB-
cord-006860-a3b8hyyr	2065	20	1.2	1.2	CD
cord-006860-a3b8hyyr	2065	21	%	%	NN
cord-006860-a3b8hyyr	2065	22	)	)	-RRB-
cord-006860-a3b8hyyr	2065	23	,	,	,
cord-006860-a3b8hyyr	2065	24	chlamidiosis	chlamidiosis	NNP
cord-006860-a3b8hyyr	2065	25	(	(	-LRB-
cord-006860-a3b8hyyr	2065	26	1.2	1.2	CD
cord-006860-a3b8hyyr	2065	27	%	%	NN
cord-006860-a3b8hyyr	2065	28	)	)	-RRB-
cord-006860-a3b8hyyr	2065	29	,	,	,
cord-006860-a3b8hyyr	2065	30	bacterial	bacterial	JJ
cord-006860-a3b8hyyr	2065	31	infection	infection	NN
cord-006860-a3b8hyyr	2065	32	(	(	-LRB-
cord-006860-a3b8hyyr	2065	33	7.2	7.2	CD
cord-006860-a3b8hyyr	2065	34	%	%	NN
cord-006860-a3b8hyyr	2065	35	}	}	-RRB-
cord-006860-a3b8hyyr	2065	36	were	be	VBD
cord-006860-a3b8hyyr	2065	37	regarded	regard	VBN
cord-006860-a3b8hyyr	2065	38	as	as	IN
cord-006860-a3b8hyyr	2065	39	infectious	infectious	JJ
cord-006860-a3b8hyyr	2065	40	complications	complication	NNS
cord-006860-a3b8hyyr	2065	41	.	.	.
cord-006860-a3b8hyyr	2066	1	Bacterial	bacterial	JJ
cord-006860-a3b8hyyr	2066	2	infections	infection	NNS
cord-006860-a3b8hyyr	2066	3	have	have	VBP
cord-006860-a3b8hyyr	2066	4	a	a	DT
cord-006860-a3b8hyyr	2066	5	routine	routine	JJ
cord-006860-a3b8hyyr	2066	6	course	course	NN
cord-006860-a3b8hyyr	2066	7	due	due	IN
cord-006860-a3b8hyyr	2066	8	to	to	IN
cord-006860-a3b8hyyr	2066	9	preserved	preserve	VBN
cord-006860-a3b8hyyr	2066	10	phagocytic	phagocytic	JJ
cord-006860-a3b8hyyr	2066	11	function	function	NN
cord-006860-a3b8hyyr	2066	12	of	of	IN
cord-006860-a3b8hyyr	2066	13	neufrophils	neufrophil	NNS
cord-006860-a3b8hyyr	2066	14	.	.	.
cord-006860-a3b8hyyr	2067	1	And	and	CC
cord-006860-a3b8hyyr	2067	2	viral	viral	JJ
cord-006860-a3b8hyyr	2067	3	infections	infection	NNS
cord-006860-a3b8hyyr	2067	4	,	,	,
cord-006860-a3b8hyyr	2067	5	whose	whose	WP$
cord-006860-a3b8hyyr	2067	6	ability	ability	NN
cord-006860-a3b8hyyr	2067	7	to	to	IN
cord-006860-a3b8hyyr	2067	8	resistance	resistance	NN
cord-006860-a3b8hyyr	2067	9	is	be	VBZ
cord-006860-a3b8hyyr	2067	10	connected	connect	VBN
cord-006860-a3b8hyyr	2067	11	with	with	IN
cord-006860-a3b8hyyr	2067	12	T	T	NNP
cord-006860-a3b8hyyr	2067	13	-cell	-cell	NN
cord-006860-a3b8hyyr	2067	14	link	link	NN
cord-006860-a3b8hyyr	2067	15	immunity	immunity	NN
cord-006860-a3b8hyyr	2067	16	,	,	,
cord-006860-a3b8hyyr	2067	17	take	take	VB
cord-006860-a3b8hyyr	2067	18	on	on	RP
cord-006860-a3b8hyyr	2067	19	a	a	DT
cord-006860-a3b8hyyr	2067	20	chronic	chronic	JJ
cord-006860-a3b8hyyr	2067	21	persistent	persistent	JJ
cord-006860-a3b8hyyr	2067	22	course	course	NN
cord-006860-a3b8hyyr	2067	23	,	,	,
cord-006860-a3b8hyyr	2067	24	Mechanism	Mechanism	NNP
cord-006860-a3b8hyyr	2067	25	of	of	IN
cord-006860-a3b8hyyr	2067	26	the	the	DT
cord-006860-a3b8hyyr	2067	27	development	development	NN
cord-006860-a3b8hyyr	2067	28	of	of	IN
cord-006860-a3b8hyyr	2067	29	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	2067	30	processes	process	NNS
cord-006860-a3b8hyyr	2067	31	(	(	-LRB-
cord-006860-a3b8hyyr	2067	32	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	2067	33	thrombocytopenic	thrombocytopenic	JJ
cord-006860-a3b8hyyr	2067	34	purpura	purpura	NN
cord-006860-a3b8hyyr	2067	35	--2.4	--2.4	:
cord-006860-a3b8hyyr	2067	36	%	%	NN
cord-006860-a3b8hyyr	2067	37	of	of	IN
cord-006860-a3b8hyyr	2067	38	pts	pt	NNS
cord-006860-a3b8hyyr	2067	39	,	,	,
cord-006860-a3b8hyyr	2067	40	immunocomplex	immunocomplex	NNP
cord-006860-a3b8hyyr	2067	41	disease	disease	NNP
cord-006860-a3b8hyyr	2067	42	--4.9	--4.9	:
cord-006860-a3b8hyyr	2067	43	%	%	NN
cord-006860-a3b8hyyr	2067	44	of	of	IN
cord-006860-a3b8hyyr	2067	45	pts	pt	NNS
cord-006860-a3b8hyyr	2067	46	,	,	,
cord-006860-a3b8hyyr	2067	47	the	the	DT
cord-006860-a3b8hyyr	2067	48	appearance	appearance	NN
cord-006860-a3b8hyyr	2067	49	of	of	IN
cord-006860-a3b8hyyr	2067	50	immune	immune	JJ
cord-006860-a3b8hyyr	2067	51	inhibifors	inhibifor	NNS
cord-006860-a3b8hyyr	2067	52	--34.4	--34.4	:
cord-006860-a3b8hyyr	2067	53	%	%	NN
cord-006860-a3b8hyyr	2067	54	of	of	IN
cord-006860-a3b8hyyr	2067	55	pts	pts	NN
cord-006860-a3b8hyyr	2067	56	}	}	-RRB-
cord-006860-a3b8hyyr	2067	57	is	be	VBZ
cord-006860-a3b8hyyr	2067	58	connected	connect	VBN
cord-006860-a3b8hyyr	2067	59	with	with	IN
cord-006860-a3b8hyyr	2067	60	the	the	DT
cord-006860-a3b8hyyr	2067	61	impairment	impairment	NN
cord-006860-a3b8hyyr	2067	62	of	of	IN
cord-006860-a3b8hyyr	2067	63	immunological	immunological	JJ
cord-006860-a3b8hyyr	2067	64	surveillance	surveillance	NN
cord-006860-a3b8hyyr	2067	65	over	over	IN
cord-006860-a3b8hyyr	2067	66	B	B	NNP
cord-006860-a3b8hyyr	2067	67	-cells	-cells	NNP
cord-006860-a3b8hyyr	2067	68	aufoimmune	aufoimmune	NNP
cord-006860-a3b8hyyr	2067	69	clones	clone	NNS
cord-006860-a3b8hyyr	2067	70	as	as	IN
cord-006860-a3b8hyyr	2067	71	a	a	DT
cord-006860-a3b8hyyr	2067	72	result	result	NN
cord-006860-a3b8hyyr	2067	73	of	of	IN
cord-006860-a3b8hyyr	2067	74	dysbalance	dysbalance	NN
cord-006860-a3b8hyyr	2067	75	in	in	IN
cord-006860-a3b8hyyr	2067	76	the	the	DT
cord-006860-a3b8hyyr	2067	77	system	system	NN
cord-006860-a3b8hyyr	2067	78	of	of	IN
cord-006860-a3b8hyyr	2067	79	T	T	NNP
cord-006860-a3b8hyyr	2067	80	-lymphocyfes	-lymphocyfes	HYPH
cord-006860-a3b8hyyr	2067	81	immunoregulatory	immunoregulatory	JJ
cord-006860-a3b8hyyr	2067	82	subpopulations	subpopulation	NNS
cord-006860-a3b8hyyr	2067	83	.	.	.
cord-006860-a3b8hyyr	2068	1	Lymphadenopathy	lymphadenopathy	JJ
cord-006860-a3b8hyyr	2068	2	and	and	CC
cord-006860-a3b8hyyr	2068	3	splenomegaly	splenomegaly	NN
cord-006860-a3b8hyyr	2068	4	(	(	-LRB-
cord-006860-a3b8hyyr	2068	5	4.9	4.9	CD
cord-006860-a3b8hyyr	2068	6	%	%	NN
cord-006860-a3b8hyyr	2068	7	)	)	-RRB-
cord-006860-a3b8hyyr	2068	8	develop	develop	VB
cord-006860-a3b8hyyr	2068	9	due	due	JJ
cord-006860-a3b8hyyr	2068	10	fo	fo	IN
cord-006860-a3b8hyyr	2068	11	benign	benign	JJ
cord-006860-a3b8hyyr	2068	12	proliferation	proliferation	NN
cord-006860-a3b8hyyr	2068	13	of	of	IN
cord-006860-a3b8hyyr	2068	14	lymphoid	lymphoid	JJ
cord-006860-a3b8hyyr	2068	15	tissue	tissue	NN
cord-006860-a3b8hyyr	2068	16	as	as	IN
cord-006860-a3b8hyyr	2068	17	a	a	DT
cord-006860-a3b8hyyr	2068	18	result	result	NN
cord-006860-a3b8hyyr	2068	19	of	of	IN
cord-006860-a3b8hyyr	2068	20	impairment	impairment	NN
cord-006860-a3b8hyyr	2068	21	of	of	IN
cord-006860-a3b8hyyr	2068	22	regulatory	regulatory	JJ
cord-006860-a3b8hyyr	2068	23	function	function	NN
cord-006860-a3b8hyyr	2068	24	of	of	IN
cord-006860-a3b8hyyr	2068	25	T	T	NNP
cord-006860-a3b8hyyr	2068	26	-lymphocytes	-lymphocyte	NNS
cord-006860-a3b8hyyr	2068	27	system	system	NN
cord-006860-a3b8hyyr	2068	28	,	,	,
cord-006860-a3b8hyyr	2068	29	or	or	CC
cord-006860-a3b8hyyr	2068	30	they	-PRON-	PRP
cord-006860-a3b8hyyr	2068	31	may	may	MD
cord-006860-a3b8hyyr	2068	32	be	be	VB
cord-006860-a3b8hyyr	2068	33	an	an	DT
cord-006860-a3b8hyyr	2068	34	evidence	evidence	NN
cord-006860-a3b8hyyr	2068	35	of	of	IN
cord-006860-a3b8hyyr	2068	36	virus	virus	NN
cord-006860-a3b8hyyr	2068	37	infection	infection	NN
cord-006860-a3b8hyyr	2068	38	.	.	.
cord-006860-a3b8hyyr	2069	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2069	2	observed	observe	VBD
cord-006860-a3b8hyyr	2069	3	one	one	CD
cord-006860-a3b8hyyr	2069	4	episode	episode	NN
cord-006860-a3b8hyyr	2069	5	of	of	IN
cord-006860-a3b8hyyr	2069	6	acute	acute	JJ
cord-006860-a3b8hyyr	2069	7	leukemia	leukemia	NN
cord-006860-a3b8hyyr	2069	8	.	.	.
cord-006860-a3b8hyyr	2070	1	Immune	immune	JJ
cord-006860-a3b8hyyr	2070	2	complications	complication	NNS
cord-006860-a3b8hyyr	2070	3	in	in	IN
cord-006860-a3b8hyyr	2070	4	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2070	5	patients	patient	NNS
cord-006860-a3b8hyyr	2070	6	develop	develop	VBP
cord-006860-a3b8hyyr	2070	7	against	against	IN
cord-006860-a3b8hyyr	2070	8	the	the	DT
cord-006860-a3b8hyyr	2070	9	background	background	NN
cord-006860-a3b8hyyr	2070	10	of	of	IN
cord-006860-a3b8hyyr	2070	11	secondary	secondary	JJ
cord-006860-a3b8hyyr	2070	12	immunodeficiency	immunodeficiency	NN
cord-006860-a3b8hyyr	2070	13	caused	cause	VBN
cord-006860-a3b8hyyr	2070	14	by	by	IN
cord-006860-a3b8hyyr	2070	15	chronic	chronic	JJ
cord-006860-a3b8hyyr	2070	16	antigenic	antigenic	JJ
cord-006860-a3b8hyyr	2070	17	stimulation	stimulation	NN
cord-006860-a3b8hyyr	2070	18	of	of	IN
cord-006860-a3b8hyyr	2070	19	patients	patient	NNS
cord-006860-a3b8hyyr	2070	20	'	'	POS
cord-006860-a3b8hyyr	2070	21	immune	immune	JJ
cord-006860-a3b8hyyr	2070	22	system	system	NN
cord-006860-a3b8hyyr	2070	23	with	with	IN
cord-006860-a3b8hyyr	2070	24	high	high	JJ
cord-006860-a3b8hyyr	2070	25	doses	dose	NNS
cord-006860-a3b8hyyr	2070	26	of	of	IN
cord-006860-a3b8hyyr	2070	27	allogenic	allogenic	JJ
cord-006860-a3b8hyyr	2070	28	proteins	protein	NNS
cord-006860-a3b8hyyr	2070	29	,	,	,
cord-006860-a3b8hyyr	2070	30	which	which	WDT
cord-006860-a3b8hyyr	2070	31	plasma	plasma	NN
cord-006860-a3b8hyyr	2070	32	preparations	preparation	NNS
cord-006860-a3b8hyyr	2070	33	contain	contain	VBP
cord-006860-a3b8hyyr	2070	34	.	.	.
cord-006860-a3b8hyyr	2071	1	In	in	IN
cord-006860-a3b8hyyr	2071	2	immune	immune	JJ
cord-006860-a3b8hyyr	2071	3	complications	complication	NNS
cord-006860-a3b8hyyr	2071	4	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2071	5	patients	patient	NNS
cord-006860-a3b8hyyr	2071	6	develop	develop	VBP
cord-006860-a3b8hyyr	2071	7	hemorrhages	hemorrhage	NNS
cord-006860-a3b8hyyr	2071	8	,	,	,
cord-006860-a3b8hyyr	2071	9	whose	whose	WP$
cord-006860-a3b8hyyr	2071	10	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	2071	11	is	be	VBZ
cord-006860-a3b8hyyr	2071	12	quite	quite	RB
cord-006860-a3b8hyyr	2071	13	different	different	JJ
cord-006860-a3b8hyyr	2071	14	from	from	IN
cord-006860-a3b8hyyr	2071	15	that	that	DT
cord-006860-a3b8hyyr	2071	16	caused	cause	VBN
cord-006860-a3b8hyyr	2071	17	by	by	IN
cord-006860-a3b8hyyr	2071	18	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2071	19	factor	factor	NN
cord-006860-a3b8hyyr	2071	20	,	,	,
cord-006860-a3b8hyyr	2071	21	so	so	IN
cord-006860-a3b8hyyr	2071	22	it	-PRON-	PRP
cord-006860-a3b8hyyr	2071	23	should	should	MD
cord-006860-a3b8hyyr	2071	24	be	be	VB
cord-006860-a3b8hyyr	2071	25	taken	take	VBN
cord-006860-a3b8hyyr	2071	26	into	into	IN
cord-006860-a3b8hyyr	2071	27	account	account	NN
cord-006860-a3b8hyyr	2071	28	in	in	IN
cord-006860-a3b8hyyr	2071	29	the	the	DT
cord-006860-a3b8hyyr	2071	30	course	course	NN
cord-006860-a3b8hyyr	2071	31	of	of	IN
cord-006860-a3b8hyyr	2071	32	treatment	treatment	NN
cord-006860-a3b8hyyr	2071	33	.	.	.
cord-006860-a3b8hyyr	2072	1	Control	control	NN
cord-006860-a3b8hyyr	2072	2	of	of	IN
cord-006860-a3b8hyyr	2072	3	hemophilia	hemophilia	NNP
cord-006860-a3b8hyyr	2072	4	therapy	therapy	NN
cord-006860-a3b8hyyr	2072	5	classically	classically	RB
cord-006860-a3b8hyyr	2072	6	was	be	VBD
cord-006860-a3b8hyyr	2072	7	based	base	VBN
cord-006860-a3b8hyyr	2072	8	on	on	IN
cord-006860-a3b8hyyr	2072	9	four	four	CD
cord-006860-a3b8hyyr	2072	10	parameters	parameter	NNS
cord-006860-a3b8hyyr	2072	11	:	:	:
cord-006860-a3b8hyyr	2072	12	life	life	NN
cord-006860-a3b8hyyr	2072	13	span	span	NN
cord-006860-a3b8hyyr	2072	14	expectancy	expectancy	NN
cord-006860-a3b8hyyr	2072	15	of	of	IN
cord-006860-a3b8hyyr	2072	16	patients	patient	NNS
cord-006860-a3b8hyyr	2072	17	,	,	,
cord-006860-a3b8hyyr	2072	18	orthopedic	orthopedic	NN
cord-006860-a3b8hyyr	2072	19	status	status	NN
cord-006860-a3b8hyyr	2072	20	(	(	-LRB-
cord-006860-a3b8hyyr	2072	21	normal	normal	JJ
cord-006860-a3b8hyyr	2072	22	zero	zero	CD
cord-006860-a3b8hyyr	2072	23	)	)	-RRB-
cord-006860-a3b8hyyr	2072	24	,	,	,
cord-006860-a3b8hyyr	2072	25	Pettersson	Pettersson	NNP
cord-006860-a3b8hyyr	2072	26	score	score	NN
cord-006860-a3b8hyyr	2072	27	and	and	CC
cord-006860-a3b8hyyr	2072	28	social	social	JJ
cord-006860-a3b8hyyr	2072	29	integration	integration	NN
cord-006860-a3b8hyyr	2072	30	.	.	.
cord-006860-a3b8hyyr	2073	1	ORen	oren	NN
cord-006860-a3b8hyyr	2073	2	,	,	,
cord-006860-a3b8hyyr	2073	3	however	however	RB
cord-006860-a3b8hyyr	2073	4	,	,	,
cord-006860-a3b8hyyr	2073	5	these	these	DT
cord-006860-a3b8hyyr	2073	6	parameters	parameter	NNS
cord-006860-a3b8hyyr	2073	7	described	describe	VBD
cord-006860-a3b8hyyr	2073	8	an	an	DT
cord-006860-a3b8hyyr	2073	9	irreversible	irreversible	JJ
cord-006860-a3b8hyyr	2073	10	status	status	NN
cord-006860-a3b8hyyr	2073	11	with	with	IN
cord-006860-a3b8hyyr	2073	12	permanent	permanent	JJ
cord-006860-a3b8hyyr	2073	13	damage	damage	NN
cord-006860-a3b8hyyr	2073	14	particularly	particularly	RB
cord-006860-a3b8hyyr	2073	15	of	of	IN
cord-006860-a3b8hyyr	2073	16	the	the	DT
cord-006860-a3b8hyyr	2073	17	joints	joint	NNS
cord-006860-a3b8hyyr	2073	18	,	,	,
cord-006860-a3b8hyyr	2073	19	especially	especially	RB
cord-006860-a3b8hyyr	2073	20	when	when	WRB
cord-006860-a3b8hyyr	2073	21	patients	patient	NNS
cord-006860-a3b8hyyr	2073	22	were	be	VBD
cord-006860-a3b8hyyr	2073	23	grown	grow	VBN
cord-006860-a3b8hyyr	2073	24	-	-	HYPH
cord-006860-a3b8hyyr	2073	25	up	up	NN
cord-006860-a3b8hyyr	2073	26	.	.	.
cord-006860-a3b8hyyr	2074	1	In	in	IN
cord-006860-a3b8hyyr	2074	2	order	order	NN
cord-006860-a3b8hyyr	2074	3	to	to	TO
cord-006860-a3b8hyyr	2074	4	establish	establish	VB
cord-006860-a3b8hyyr	2074	5	risk	risk	NN
cord-006860-a3b8hyyr	2074	6	-	-	HYPH
cord-006860-a3b8hyyr	2074	7	adapted	adapt	VBN
cord-006860-a3b8hyyr	2074	8	therapy	therapy	NN
cord-006860-a3b8hyyr	2074	9	protocols	protocol	NNS
cord-006860-a3b8hyyr	2074	10	to	to	TO
cord-006860-a3b8hyyr	2074	11	prevent	prevent	VB
cord-006860-a3b8hyyr	2074	12	hemophllic	hemophllic	NNP
cord-006860-a3b8hyyr	2074	13	osteoarthropathies	osteoarthropathie	NNS
cord-006860-a3b8hyyr	2074	14	,	,	,
cord-006860-a3b8hyyr	2074	15	quality	quality	NN
cord-006860-a3b8hyyr	2074	16	control	control	NN
cord-006860-a3b8hyyr	2074	17	programs	program	NNS
cord-006860-a3b8hyyr	2074	18	have	have	VBP
cord-006860-a3b8hyyr	2074	19	to	to	TO
cord-006860-a3b8hyyr	2074	20	he	-PRON-	PRP
cord-006860-a3b8hyyr	2074	21	set	set	VB
cord-006860-a3b8hyyr	2074	22	-	-	HYPH
cord-006860-a3b8hyyr	2074	23	up	up	NN
cord-006860-a3b8hyyr	2074	24	that	that	WDT
cord-006860-a3b8hyyr	2074	25	allow	allow	VBP
cord-006860-a3b8hyyr	2074	26	for	for	IN
cord-006860-a3b8hyyr	2074	27	early	early	JJ
cord-006860-a3b8hyyr	2074	28	adjustment	adjustment	NN
cord-006860-a3b8hyyr	2074	29	of	of	IN
cord-006860-a3b8hyyr	2074	30	dosage	dosage	NN
cord-006860-a3b8hyyr	2074	31	and	and	CC
cord-006860-a3b8hyyr	2074	32	substitution	substitution	NN
cord-006860-a3b8hyyr	2074	33	frequency	frequency	NN
cord-006860-a3b8hyyr	2074	34	.	.	.
cord-006860-a3b8hyyr	2075	1	Here	here	RB
cord-006860-a3b8hyyr	2075	2	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2075	3	frequency	frequency	NN
cord-006860-a3b8hyyr	2075	4	is	be	VBZ
cord-006860-a3b8hyyr	2075	5	one	one	CD
cord-006860-a3b8hyyr	2075	6	the	the	DT
cord-006860-a3b8hyyr	2075	7	main	main	JJ
cord-006860-a3b8hyyr	2075	8	parameters	parameter	NNS
cord-006860-a3b8hyyr	2075	9	,	,	,
cord-006860-a3b8hyyr	2075	10	being	be	VBG
cord-006860-a3b8hyyr	2075	11	a	a	DT
cord-006860-a3b8hyyr	2075	12	clear	clear	JJ
cord-006860-a3b8hyyr	2075	13	hint	hint	NN
cord-006860-a3b8hyyr	2075	14	for	for	IN
cord-006860-a3b8hyyr	2075	15	the	the	DT
cord-006860-a3b8hyyr	2075	16	possible	possible	JJ
cord-006860-a3b8hyyr	2075	17	development	development	NN
cord-006860-a3b8hyyr	2075	18	of	of	IN
cord-006860-a3b8hyyr	2075	19	a	a	DT
cord-006860-a3b8hyyr	2075	20	target	target	NN
cord-006860-a3b8hyyr	2075	21	joint	joint	NN
cord-006860-a3b8hyyr	2075	22	.	.	.
cord-006860-a3b8hyyr	2076	1	Since	since	IN
cord-006860-a3b8hyyr	2076	2	1988	1988	CD
cord-006860-a3b8hyyr	2076	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	2076	4	have	have	VBP
cord-006860-a3b8hyyr	2076	5	established	establish	VBN
cord-006860-a3b8hyyr	2076	6	a	a	DT
cord-006860-a3b8hyyr	2076	7	computer	computer	NN
cord-006860-a3b8hyyr	2076	8	database	database	NN
cord-006860-a3b8hyyr	2076	9	(	(	-LRB-
cord-006860-a3b8hyyr	2076	10	Haemopat	Haemopat	NNP
cord-006860-a3b8hyyr	2076	11	)	)	-RRB-
cord-006860-a3b8hyyr	2076	12	that	that	WDT
cord-006860-a3b8hyyr	2076	13	contains	contain	VBZ
cord-006860-a3b8hyyr	2076	14	data	datum	NNS
cord-006860-a3b8hyyr	2076	15	from	from	IN
cord-006860-a3b8hyyr	2076	16	all	all	DT
cord-006860-a3b8hyyr	2076	17	patients	patient	NNS
cord-006860-a3b8hyyr	2076	18	treated	treat	VBN
cord-006860-a3b8hyyr	2076	19	in	in	IN
cord-006860-a3b8hyyr	2076	20	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2076	21	center	center	NN
cord-006860-a3b8hyyr	2076	22	.	.	.
cord-006860-a3b8hyyr	2077	1	Tables	table	NNS
cord-006860-a3b8hyyr	2077	2	and	and	CC
cord-006860-a3b8hyyr	2077	3	graphs	graph	NNS
cord-006860-a3b8hyyr	2077	4	allow	allow	VBP
cord-006860-a3b8hyyr	2077	5	for	for	IN
cord-006860-a3b8hyyr	2077	6	early	early	JJ
cord-006860-a3b8hyyr	2077	7	detection	detection	NN
cord-006860-a3b8hyyr	2077	8	of	of	IN
cord-006860-a3b8hyyr	2077	9	increased	increase	VBN
cord-006860-a3b8hyyr	2077	10	bleeding	bleeding	NN
cord-006860-a3b8hyyr	2077	11	tendency	tendency	NN
cord-006860-a3b8hyyr	2077	12	in	in	IN
cord-006860-a3b8hyyr	2077	13	a	a	DT
cord-006860-a3b8hyyr	2077	14	given	give	VBN
cord-006860-a3b8hyyr	2077	15	joint	joint	NN
cord-006860-a3b8hyyr	2077	16	,	,	,
cord-006860-a3b8hyyr	2077	17	and	and	CC
cord-006860-a3b8hyyr	2077	18	accordingly	accordingly	RB
cord-006860-a3b8hyyr	2077	19	for	for	IN
cord-006860-a3b8hyyr	2077	20	adjustment	adjustment	NN
cord-006860-a3b8hyyr	2077	21	of	of	IN
cord-006860-a3b8hyyr	2077	22	therapy	therapy	NN
cord-006860-a3b8hyyr	2077	23	.	.	.
cord-006860-a3b8hyyr	2078	1	The	the	DT
cord-006860-a3b8hyyr	2078	2	results	result	NNS
cord-006860-a3b8hyyr	2078	3	of	of	IN
cord-006860-a3b8hyyr	2078	4	8	8	CD
cord-006860-a3b8hyyr	2078	5	years	year	NNS
cord-006860-a3b8hyyr	2078	6	of	of	IN
cord-006860-a3b8hyyr	2078	7	measuring	measure	VBG
cord-006860-a3b8hyyr	2078	8	reasons	reason	NNS
cord-006860-a3b8hyyr	2078	9	of	of	IN
cord-006860-a3b8hyyr	2078	10	joint	joint	JJ
cord-006860-a3b8hyyr	2078	11	damage	damage	NN
cord-006860-a3b8hyyr	2078	12	and	and	CC
cord-006860-a3b8hyyr	2078	13	not	not	RB
cord-006860-a3b8hyyr	2078	14	documenting	document	VBG
cord-006860-a3b8hyyr	2078	15	the	the	DT
cord-006860-a3b8hyyr	2078	16	orthopathies	orthopathie	NNS
cord-006860-a3b8hyyr	2078	17	as	as	IN
cord-006860-a3b8hyyr	2078	18	such	such	JJ
cord-006860-a3b8hyyr	2078	19	will	will	MD
cord-006860-a3b8hyyr	2078	20	be	be	VB
cord-006860-a3b8hyyr	2078	21	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	2078	22	.	.	.
cord-006860-a3b8hyyr	2079	1	Parallelly	parallelly	RB
cord-006860-a3b8hyyr	2079	2	a	a	DT
cord-006860-a3b8hyyr	2079	3	new	new	JJ
cord-006860-a3b8hyyr	2079	4	program	program	NN
cord-006860-a3b8hyyr	2079	5	(	(	-LRB-
cord-006860-a3b8hyyr	2079	6	Haemopat	Haemopat	NNP
cord-006860-a3b8hyyr	2079	7	Win	Win	NNP
cord-006860-a3b8hyyr	2079	8	1.0	1.0	CD
cord-006860-a3b8hyyr	2079	9	)	)	-RRB-
cord-006860-a3b8hyyr	2080	1	will	will	MD
cord-006860-a3b8hyyr	2080	2	he	-PRON-	PRP
cord-006860-a3b8hyyr	2080	3	introduced	introduce	VBD
cord-006860-a3b8hyyr	2080	4	allowing	allow	VBG
cord-006860-a3b8hyyr	2080	5	for	for	IN
cord-006860-a3b8hyyr	2080	6	easier	easy	JJR
cord-006860-a3b8hyyr	2080	7	handling	handling	NN
cord-006860-a3b8hyyr	2080	8	of	of	IN
cord-006860-a3b8hyyr	2080	9	data	datum	NNS
cord-006860-a3b8hyyr	2080	10	and	and	CC
cord-006860-a3b8hyyr	2080	11	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2080	12	evaluation	evaluation	NN
cord-006860-a3b8hyyr	2080	13	.	.	.
cord-006860-a3b8hyyr	2081	1	This	this	DT
cord-006860-a3b8hyyr	2081	2	program	program	NN
cord-006860-a3b8hyyr	2081	3	will	will	MD
cord-006860-a3b8hyyr	2081	4	be	be	VB
cord-006860-a3b8hyyr	2081	5	used	use	VBN
cord-006860-a3b8hyyr	2081	6	as	as	IN
cord-006860-a3b8hyyr	2081	7	of	of	IN
cord-006860-a3b8hyyr	2081	8	December	December	NNP
cord-006860-a3b8hyyr	2081	9	1995	1995	CD
cord-006860-a3b8hyyr	2081	10	.	.	.
cord-006860-a3b8hyyr	2082	1	In	in	IN
cord-006860-a3b8hyyr	2082	2	combination	combination	NN
cord-006860-a3b8hyyr	2082	3	with	with	IN
cord-006860-a3b8hyyr	2082	4	a	a	DT
cord-006860-a3b8hyyr	2082	5	substitution	substitution	NN
cord-006860-a3b8hyyr	2082	6	calender	calender	NN
cord-006860-a3b8hyyr	2082	7	to	to	TO
cord-006860-a3b8hyyr	2082	8	be	be	VB
cord-006860-a3b8hyyr	2082	9	filled	fill	VBN
cord-006860-a3b8hyyr	2082	10	in	in	RP
cord-006860-a3b8hyyr	2082	11	by	by	IN
cord-006860-a3b8hyyr	2082	12	all	all	DT
cord-006860-a3b8hyyr	2082	13	patients	patient	NNS
cord-006860-a3b8hyyr	2082	14	,	,	,
cord-006860-a3b8hyyr	2082	15	in	in	IN
cord-006860-a3b8hyyr	2082	16	which	which	WDT
cord-006860-a3b8hyyr	2082	17	factor	factor	NN
cord-006860-a3b8hyyr	2082	18	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	2082	19	,	,	,
cord-006860-a3b8hyyr	2082	20	lot	lot	NN
cord-006860-a3b8hyyr	2082	21	numbers	number	NNS
cord-006860-a3b8hyyr	2082	22	,	,	,
cord-006860-a3b8hyyr	2082	23	dosage	dosage	NN
cord-006860-a3b8hyyr	2082	24	,	,	,
cord-006860-a3b8hyyr	2082	25	and	and	CC
cord-006860-a3b8hyyr	2082	26	date	date	NN
cord-006860-a3b8hyyr	2082	27	of	of	IN
cord-006860-a3b8hyyr	2082	28	administration	administration	NN
cord-006860-a3b8hyyr	2082	29	will	will	MD
cord-006860-a3b8hyyr	2082	30	he	-PRON-	PRP
cord-006860-a3b8hyyr	2082	31	constantly	constantly	RB
cord-006860-a3b8hyyr	2082	32	recorded	record	VBD
cord-006860-a3b8hyyr	2082	33	,	,	,
cord-006860-a3b8hyyr	2082	34	this	this	DT
cord-006860-a3b8hyyr	2082	35	program	program	NN
cord-006860-a3b8hyyr	2082	36	will	will	MD
cord-006860-a3b8hyyr	2082	37	extend	extend	VB
cord-006860-a3b8hyyr	2082	38	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2082	39	existing	exist	VBG
cord-006860-a3b8hyyr	2082	40	database	database	NN
cord-006860-a3b8hyyr	2082	41	in	in	IN
cord-006860-a3b8hyyr	2082	42	order	order	NN
cord-006860-a3b8hyyr	2082	43	to	to	TO
cord-006860-a3b8hyyr	2082	44	follow	follow	VB
cord-006860-a3b8hyyr	2082	45	closely	closely	RB
cord-006860-a3b8hyyr	2082	46	clinical	clinical	JJ
cord-006860-a3b8hyyr	2082	47	and	and	CC
cord-006860-a3b8hyyr	2082	48	orthopedic	orthopedic	JJ
cord-006860-a3b8hyyr	2082	49	parameters	parameter	NNS
cord-006860-a3b8hyyr	2082	50	of	of	IN
cord-006860-a3b8hyyr	2082	51	each	each	DT
cord-006860-a3b8hyyr	2082	52	patient	patient	NN
cord-006860-a3b8hyyr	2082	53	,	,	,
cord-006860-a3b8hyyr	2082	54	and	and	CC
cord-006860-a3b8hyyr	2082	55	consequently	consequently	RB
cord-006860-a3b8hyyr	2082	56	acts	act	VBZ
cord-006860-a3b8hyyr	2082	57	as	as	IN
cord-006860-a3b8hyyr	2082	58	strict	strict	JJ
cord-006860-a3b8hyyr	2082	59	control	control	NN
cord-006860-a3b8hyyr	2082	60	of	of	IN
cord-006860-a3b8hyyr	2082	61	therapy	therapy	NN
cord-006860-a3b8hyyr	2082	62	quality	quality	NN
cord-006860-a3b8hyyr	2082	63	.	.	.
cord-006860-a3b8hyyr	2083	1	Additionally	additionally	RB
cord-006860-a3b8hyyr	2083	2	,	,	,
cord-006860-a3b8hyyr	2083	3	it	-PRON-	PRP
cord-006860-a3b8hyyr	2083	4	provides	provide	VBZ
cord-006860-a3b8hyyr	2083	5	sufficient	sufficient	JJ
cord-006860-a3b8hyyr	2083	6	data	datum	NNS
cord-006860-a3b8hyyr	2083	7	to	to	TO
cord-006860-a3b8hyyr	2083	8	fulfil	fulfil	VB
cord-006860-a3b8hyyr	2083	9	any	any	DT
cord-006860-a3b8hyyr	2083	10	documentation	documentation	NN
cord-006860-a3b8hyyr	2083	11	needs	need	NNS
cord-006860-a3b8hyyr	2083	12	,	,	,
cord-006860-a3b8hyyr	2083	13	requested	request	VBN
cord-006860-a3b8hyyr	2083	14	by	by	IN
cord-006860-a3b8hyyr	2083	15	medical	medical	JJ
cord-006860-a3b8hyyr	2083	16	authorities	authority	NNS
cord-006860-a3b8hyyr	2083	17	.	.	.
cord-006860-a3b8hyyr	2084	1	The	the	DT
cord-006860-a3b8hyyr	2084	2	program	program	NN
cord-006860-a3b8hyyr	2084	3	will	will	MD
cord-006860-a3b8hyyr	2084	4	be	be	VB
cord-006860-a3b8hyyr	2084	5	available	available	JJ
cord-006860-a3b8hyyr	2084	6	for	for	IN
cord-006860-a3b8hyyr	2084	7	all	all	PDT
cord-006860-a3b8hyyr	2084	8	those	those	DT
cord-006860-a3b8hyyr	2084	9	interested	interested	JJ
cord-006860-a3b8hyyr	2084	10	free	free	JJ
cord-006860-a3b8hyyr	2084	11	of	of	IN
cord-006860-a3b8hyyr	2084	12	charge	charge	NN
cord-006860-a3b8hyyr	2084	13	.	.	.
cord-006860-a3b8hyyr	2085	1	2	2	LS
cord-006860-a3b8hyyr	2085	2	)	)	-RRB-
cord-006860-a3b8hyyr	2085	3	Kinderklinik	Kinderklinik	NNP
cord-006860-a3b8hyyr	2085	4	der	der	NNP
cord-006860-a3b8hyyr	2085	5	Westf	Westf	NNP
cord-006860-a3b8hyyr	2085	6	.	.	.
cord-006860-a3b8hyyr	2086	1	Wilhelms	Wilhelms	NNP
cord-006860-a3b8hyyr	2086	2	Univ	Univ	NNP
cord-006860-a3b8hyyr	2086	3	.	.	.
cord-006860-a3b8hyyr	2087	1	Mttuster	Mttuster	NNP
cord-006860-a3b8hyyr	2087	2	3	3	CD
cord-006860-a3b8hyyr	2087	3	-	-	SYM
cord-006860-a3b8hyyr	2087	4	6	6	CD
cord-006860-a3b8hyyr	2087	5	)	)	-RRB-
cord-006860-a3b8hyyr	2088	1	Biotest	Biotest	NNP
cord-006860-a3b8hyyr	2088	2	Pharma	Pharma	NNP
cord-006860-a3b8hyyr	2088	3	GmbH	GmbH	NNP
cord-006860-a3b8hyyr	2088	4	,	,	,
cord-006860-a3b8hyyr	2088	5	Dreieich	Dreieich	NNP
cord-006860-a3b8hyyr	2088	6	Haemoctin	Haemoctin	NNP
cord-006860-a3b8hyyr	2088	7	®	®	POS
cord-006860-a3b8hyyr	2088	8	SDH	SDH	NNP
cord-006860-a3b8hyyr	2088	9	;	;	:
cord-006860-a3b8hyyr	2089	1	the	the	DT
cord-006860-a3b8hyyr	2089	2	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2089	3	SDH	SDH	NNP
cord-006860-a3b8hyyr	2089	4	(	(	-LRB-
cord-006860-a3b8hyyr	2089	5	SDH	SDH	NNP
cord-006860-a3b8hyyr	2089	6	=	=	SYM
cord-006860-a3b8hyyr	2089	7	solvent	solvent	NN
cord-006860-a3b8hyyr	2089	8	detergent	detergent	NN
cord-006860-a3b8hyyr	2089	9	and	and	CC
cord-006860-a3b8hyyr	2089	10	dry	dry	JJ
cord-006860-a3b8hyyr	2089	11	heat	heat	NN
cord-006860-a3b8hyyr	2089	12	=	=	SYM
cord-006860-a3b8hyyr	2089	13	100	100	CD
cord-006860-a3b8hyyr	2089	14	°	°	NN
cord-006860-a3b8hyyr	2089	15	C	c	NN
cord-006860-a3b8hyyr	2089	16	,	,	,
cord-006860-a3b8hyyr	2089	17	30	30	CD
cord-006860-a3b8hyyr	2089	18	rain	rain	NN
cord-006860-a3b8hyyr	2089	19	)	)	-RRB-
cord-006860-a3b8hyyr	2089	20	from	from	IN
cord-006860-a3b8hyyr	2089	21	Biotest	Biotest	NNP
cord-006860-a3b8hyyr	2089	22	Pharma	Pharma	NNP
cord-006860-a3b8hyyr	2089	23	is	be	VBZ
cord-006860-a3b8hyyr	2089	24	a	a	DT
cord-006860-a3b8hyyr	2089	25	high	high	JJ
cord-006860-a3b8hyyr	2089	26	purity	purity	NN
cord-006860-a3b8hyyr	2089	27	(	(	-LRB-
cord-006860-a3b8hyyr	2089	28	specific	specific	JJ
cord-006860-a3b8hyyr	2089	29	activity	activity	NN
cord-006860-a3b8hyyr	2089	30	~	~	NFP
cord-006860-a3b8hyyr	2089	31	100	100	CD
cord-006860-a3b8hyyr	2089	32	)	)	-RRB-
cord-006860-a3b8hyyr	2089	33	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2089	34	concentrate	concentrate	VBP
cord-006860-a3b8hyyr	2089	35	manufactured	manufacture	VBN
cord-006860-a3b8hyyr	2089	36	from	from	IN
cord-006860-a3b8hyyr	2089	37	large	large	JJ
cord-006860-a3b8hyyr	2089	38	human	human	JJ
cord-006860-a3b8hyyr	2089	39	plasma	plasma	NN
cord-006860-a3b8hyyr	2089	40	pools	pool	NNS
cord-006860-a3b8hyyr	2089	41	.	.	.
cord-006860-a3b8hyyr	2090	1	Virus	virus	NN
cord-006860-a3b8hyyr	2090	2	validation	validation	NN
cord-006860-a3b8hyyr	2090	3	studies	study	NNS
cord-006860-a3b8hyyr	2090	4	have	have	VBP
cord-006860-a3b8hyyr	2090	5	shown	show	VBN
cord-006860-a3b8hyyr	2090	6	virus	virus	NN
cord-006860-a3b8hyyr	2090	7	inactivation	inactivation	NN
cord-006860-a3b8hyyr	2090	8	/	/	SYM
cord-006860-a3b8hyyr	2090	9	reduction	reduction	NN
cord-006860-a3b8hyyr	2090	10	(	(	-LRB-
cord-006860-a3b8hyyr	2090	11	log	log	NN
cord-006860-a3b8hyyr	2090	12	10	10	CD
cord-006860-a3b8hyyr	2090	13	)	)	-RRB-
cord-006860-a3b8hyyr	2090	14	during	during	IN
cord-006860-a3b8hyyr	2090	15	the	the	DT
cord-006860-a3b8hyyr	2090	16	manufacturing	manufacturing	NN
cord-006860-a3b8hyyr	2090	17	process	process	NN
cord-006860-a3b8hyyr	2090	18	for	for	IN
cord-006860-a3b8hyyr	2090	19	lipid	lipid	NN
cord-006860-a3b8hyyr	2090	20	coated	coat	VBN
cord-006860-a3b8hyyr	2090	21	vints~	vints~	NNP
cord-006860-a3b8hyyr	2090	22	such	such	JJ
cord-006860-a3b8hyyr	2090	23	as	as	IN
cord-006860-a3b8hyyr	2090	24	:	:	:
cord-006860-a3b8hyyr	2090	25	H]V-1	H]V-1	NNP
cord-006860-a3b8hyyr	2090	26	>	>	XX
cord-006860-a3b8hyyr	2090	27	16.2	16.2	CD
cord-006860-a3b8hyyr	2090	28	;	;	:
cord-006860-a3b8hyyr	2090	29	PSR	PSR	NNP
cord-006860-a3b8hyyr	2090	30	>	>	XX
cord-006860-a3b8hyyr	2090	31	16.8	16.8	CD
cord-006860-a3b8hyyr	2090	32	;	;	:
cord-006860-a3b8hyyr	2090	33	VSV	VSV	NNP
cord-006860-a3b8hyyr	2090	34	>	>	XX
cord-006860-a3b8hyyr	2090	35	14,5	14,5	CD
cord-006860-a3b8hyyr	2090	36	;	;	.
cord-006860-a3b8hyyr	2091	1	BVDV	BVDV	NNP
cord-006860-a3b8hyyr	2091	2	>	>	XX
cord-006860-a3b8hyyr	2091	3	15.7	15.7	CD
cord-006860-a3b8hyyr	2091	4	;	;	:
cord-006860-a3b8hyyr	2091	5	HCV	HCV	NNP
cord-006860-a3b8hyyr	2091	6	>	>	XX
cord-006860-a3b8hyyr	2092	1	4.5	4.5	CD
cord-006860-a3b8hyyr	2092	2	*	*	NFP
cord-006860-a3b8hyyr	2092	3	and	and	CC
cord-006860-a3b8hyyr	2092	4	non	non	JJ
cord-006860-a3b8hyyr	2092	5	enveloped	envelop	VBN
cord-006860-a3b8hyyr	2092	6	vimsas	vimsas	RB
cord-006860-a3b8hyyr	2092	7	such	such	JJ
cord-006860-a3b8hyyr	2092	8	as	as	IN
cord-006860-a3b8hyyr	2092	9	:	:	:
cord-006860-a3b8hyyr	2092	10	Parvo	Parvo	NNP
cord-006860-a3b8hyyr	2092	11	*	*	NFP
cord-006860-a3b8hyyr	2092	12	*	*	NFP
cord-006860-a3b8hyyr	2092	13	=	=	SYM
cord-006860-a3b8hyyr	2092	14	2.7	2.7	CD
cord-006860-a3b8hyyr	2092	15	;	;	:
cord-006860-a3b8hyyr	2092	16	Reo	Reo	NNP
cord-006860-a3b8hyyr	2092	17	>	>	XX
cord-006860-a3b8hyyr	2093	1	5.3	5.3	CD
cord-006860-a3b8hyyr	2094	1	*	*	NFP
cord-006860-a3b8hyyr	2094	2	*	*	NFP
cord-006860-a3b8hyyr	2094	3	*	*	NFP
cord-006860-a3b8hyyr	2094	4	and	and	CC
cord-006860-a3b8hyyr	2094	5	HAV	HAV	NNP
cord-006860-a3b8hyyr	2095	1	>	>	XX
cord-006860-a3b8hyyr	2096	1	13.9	13.9	CD
cord-006860-a3b8hyyr	2096	2	.	.	.
cord-006860-a3b8hyyr	2097	1	More	More	JJR
cord-006860-a3b8hyyr	2097	2	than	than	IN
cord-006860-a3b8hyyr	2097	3	50	50	CD
cord-006860-a3b8hyyr	2097	4	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2098	1	A	a	DT
cord-006860-a3b8hyyr	2098	2	patients	patient	NNS
cord-006860-a3b8hyyr	2098	3	(	(	-LRB-
cord-006860-a3b8hyyr	2098	4	PTPs	ptp	NNS
cord-006860-a3b8hyyr	2098	5	=	=	SYM
cord-006860-a3b8hyyr	2098	6	previously	previously	RB
cord-006860-a3b8hyyr	2098	7	treated	treat	VBN
cord-006860-a3b8hyyr	2098	8	patients	patient	NNS
cord-006860-a3b8hyyr	2098	9	)	)	-RRB-
cord-006860-a3b8hyyr	2098	10	,	,	,
cord-006860-a3b8hyyr	2098	11	baseline	baseline	JJ
cord-006860-a3b8hyyr	2098	12	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2098	13	activity	activity	NN
cord-006860-a3b8hyyr	2098	14	<	<	XX
cord-006860-a3b8hyyr	2098	15	1	1	CD
cord-006860-a3b8hyyr	2098	16	%	%	NN
cord-006860-a3b8hyyr	2098	17	,	,	,
cord-006860-a3b8hyyr	2098	18	were	be	VBD
cord-006860-a3b8hyyr	2098	19	included	include	VBN
cord-006860-a3b8hyyr	2098	20	in	in	IN
cord-006860-a3b8hyyr	2098	21	an	an	DT
cord-006860-a3b8hyyr	2098	22	international	international	JJ
cord-006860-a3b8hyyr	2098	23	drug	drug	NN
cord-006860-a3b8hyyr	2098	24	monitoring	monitoring	NN
cord-006860-a3b8hyyr	2098	25	study	study	NN
cord-006860-a3b8hyyr	2098	26	to	to	TO
cord-006860-a3b8hyyr	2098	27	follow	follow	VB
cord-006860-a3b8hyyr	2098	28	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2098	29	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2098	30	inhibitur	inhibitur	NN
cord-006860-a3b8hyyr	2098	31	status	status	NN
cord-006860-a3b8hyyr	2098	32	.	.	.
cord-006860-a3b8hyyr	2099	1	The	the	DT
cord-006860-a3b8hyyr	2099	2	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2099	3	Centers	Centers	NNPS
cord-006860-a3b8hyyr	2099	4	included	include	VBD
cord-006860-a3b8hyyr	2099	5	were	be	VBD
cord-006860-a3b8hyyr	2099	6	three	three	CD
cord-006860-a3b8hyyr	2099	7	Centers	Centers	NNPS
cord-006860-a3b8hyyr	2099	8	from	from	IN
cord-006860-a3b8hyyr	2099	9	Hungaria	Hungaria	NNP
cord-006860-a3b8hyyr	2099	10	(	(	-LRB-
cord-006860-a3b8hyyr	2099	11	Helm	Helm	NNP
cord-006860-a3b8hyyr	2099	12	Pal	Pal	NNP
cord-006860-a3b8hyyr	2099	13	Children	Children	NNP
cord-006860-a3b8hyyr	2099	14	Hospital	Hospital	NNP
cord-006860-a3b8hyyr	2099	15	and	and	CC
cord-006860-a3b8hyyr	2099	16	the	the	DT
cord-006860-a3b8hyyr	2099	17	National	National	NNP
cord-006860-a3b8hyyr	2099	18	Inst	Inst	NNP
cord-006860-a3b8hyyr	2099	19	.	.	NNP
cord-006860-a3b8hyyr	2099	20	of	of	IN
cord-006860-a3b8hyyr	2099	21	Haematology	Haematology	NNP
cord-006860-a3b8hyyr	2099	22	,	,	,
cord-006860-a3b8hyyr	2099	23	Budapest	Budapest	NNP
cord-006860-a3b8hyyr	2099	24	and	and	CC
cord-006860-a3b8hyyr	2099	25	Regional	Regional	NNP
cord-006860-a3b8hyyr	2099	26	Blood	Blood	NNP
cord-006860-a3b8hyyr	2099	27	Transfusion	Transfusion	NNP
cord-006860-a3b8hyyr	2099	28	Center	Center	NNP
cord-006860-a3b8hyyr	2099	29	,	,	,
cord-006860-a3b8hyyr	2099	30	Debrecen	Debrecen	NNP
cord-006860-a3b8hyyr	2099	31	)	)	-RRB-
cord-006860-a3b8hyyr	2099	32	and	and	CC
cord-006860-a3b8hyyr	2099	33	four	four	CD
cord-006860-a3b8hyyr	2099	34	Centers	Centers	NNPS
cord-006860-a3b8hyyr	2099	35	from	from	IN
cord-006860-a3b8hyyr	2099	36	Germany	Germany	NNP
cord-006860-a3b8hyyr	2099	37	(	(	-LRB-
cord-006860-a3b8hyyr	2099	38	two	two	CD
cord-006860-a3b8hyyr	2099	39	from	from	IN
cord-006860-a3b8hyyr	2099	40	Berlin	Berlin	NNP
cord-006860-a3b8hyyr	2099	41	,	,	,
cord-006860-a3b8hyyr	2099	42	one	one	CD
cord-006860-a3b8hyyr	2099	43	FraukfurffMain	FraukfurffMain	NNP
cord-006860-a3b8hyyr	2099	44	and	and	CC
cord-006860-a3b8hyyr	2099	45	one	one	CD
cord-006860-a3b8hyyr	2099	46	MOnster	monster	NN
cord-006860-a3b8hyyr	2099	47	)	)	-RRB-
cord-006860-a3b8hyyr	2099	48	.	.	.
cord-006860-a3b8hyyr	2100	1	Patients	patient	NNS
cord-006860-a3b8hyyr	2100	2	were	be	VBD
cord-006860-a3b8hyyr	2100	3	enrolled	enrol	VBN
cord-006860-a3b8hyyr	2100	4	in	in	IN
cord-006860-a3b8hyyr	2100	5	the	the	DT
cord-006860-a3b8hyyr	2100	6	drug	drug	NN
cord-006860-a3b8hyyr	2100	7	monitoring	monitoring	NN
cord-006860-a3b8hyyr	2100	8	beginning	begin	VBG
cord-006860-a3b8hyyr	2100	9	Aug.	August	NNP
cord-006860-a3b8hyyr	2100	10	1993	1993	CD
cord-006860-a3b8hyyr	2100	11	.	.	.
cord-006860-a3b8hyyr	2101	1	At	at	IN
cord-006860-a3b8hyyr	2101	2	the	the	DT
cord-006860-a3b8hyyr	2101	3	entry	entry	NN
cord-006860-a3b8hyyr	2101	4	none	none	NN
cord-006860-a3b8hyyr	2101	5	of	of	IN
cord-006860-a3b8hyyr	2101	6	the	the	DT
cord-006860-a3b8hyyr	2101	7	patients	patient	NNS
cord-006860-a3b8hyyr	2101	8	had	have	VBD
cord-006860-a3b8hyyr	2101	9	a	a	DT
cord-006860-a3b8hyyr	2101	10	detectable	detectable	JJ
cord-006860-a3b8hyyr	2101	11	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2101	12	.	.	.
cord-006860-a3b8hyyr	2102	1	At	at	IN
cord-006860-a3b8hyyr	2102	2	the	the	DT
cord-006860-a3b8hyyr	2102	3	end	end	NN
cord-006860-a3b8hyyr	2102	4	of	of	IN
cord-006860-a3b8hyyr	2102	5	Sept.	September	NNP
cord-006860-a3b8hyyr	2102	6	1995	1995	CD
cord-006860-a3b8hyyr	2102	7	there	there	EX
cord-006860-a3b8hyyr	2102	8	were	be	VBD
cord-006860-a3b8hyyr	2102	9	no	no	DT
cord-006860-a3b8hyyr	2102	10	side	side	NN
cord-006860-a3b8hyyr	2102	11	effects	effect	NNS
cord-006860-a3b8hyyr	2102	12	or	or	CC
cord-006860-a3b8hyyr	2102	13	adverse	adverse	JJ
cord-006860-a3b8hyyr	2102	14	events	event	NNS
cord-006860-a3b8hyyr	2102	15	in	in	IN
cord-006860-a3b8hyyr	2102	16	connection	connection	NN
cord-006860-a3b8hyyr	2102	17	with	with	IN
cord-006860-a3b8hyyr	2102	18	the	the	DT
cord-006860-a3b8hyyr	2102	19	use	use	NN
cord-006860-a3b8hyyr	2102	20	of	of	IN
cord-006860-a3b8hyyr	2102	21	Haemuetin	Haemuetin	NNP
cord-006860-a3b8hyyr	2102	22	®	®	.
cord-006860-a3b8hyyr	2102	23	.	.	.
cord-006860-a3b8hyyr	2103	1	Before	before	IN
cord-006860-a3b8hyyr	2103	2	the	the	DT
cord-006860-a3b8hyyr	2103	3	Haemoctin	Haemoctin	NNP
cord-006860-a3b8hyyr	2103	4	drug	drug	NN
cord-006860-a3b8hyyr	2103	5	monitoring	monitoring	NN
cord-006860-a3b8hyyr	2103	6	study	study	NN
cord-006860-a3b8hyyr	2103	7	,	,	,
cord-006860-a3b8hyyr	2103	8	the	the	DT
cord-006860-a3b8hyyr	2103	9	patients	patient	NNS
cord-006860-a3b8hyyr	2103	10	were	be	VBD
cord-006860-a3b8hyyr	2103	11	treated	treat	VBN
cord-006860-a3b8hyyr	2103	12	with	with	IN
cord-006860-a3b8hyyr	2103	13	cryoprecipitate	cryoprecipitate	NNP
cord-006860-a3b8hyyr	2103	14	,	,	,
cord-006860-a3b8hyyr	2103	15	or	or	CC
cord-006860-a3b8hyyr	2103	16	purified	purify	VBN
cord-006860-a3b8hyyr	2103	17	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2103	18	products	product	NNS
cord-006860-a3b8hyyr	2103	19	.	.	.
cord-006860-a3b8hyyr	2104	1	Inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2104	2	testing	testing	NN
cord-006860-a3b8hyyr	2104	3	was	be	VBD
cord-006860-a3b8hyyr	2104	4	done	do	VBN
cord-006860-a3b8hyyr	2104	5	on	on	IN
cord-006860-a3b8hyyr	2104	6	patients	patient	NNS
cord-006860-a3b8hyyr	2104	7	plasma	plasma	NN
cord-006860-a3b8hyyr	2104	8	samples	sample	NNS
cord-006860-a3b8hyyr	2104	9	using	use	VBG
cord-006860-a3b8hyyr	2104	10	the	the	DT
cord-006860-a3b8hyyr	2104	11	Bethesda	Bethesda	NNP
cord-006860-a3b8hyyr	2104	12	method	method	NN
cord-006860-a3b8hyyr	2104	13	.	.	.
cord-006860-a3b8hyyr	2105	1	Repeated	repeat	VBN
cord-006860-a3b8hyyr	2105	2	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2105	3	recovery	recovery	NN
cord-006860-a3b8hyyr	2105	4	determination	determination	NN
cord-006860-a3b8hyyr	2105	5	at	at	IN
cord-006860-a3b8hyyr	2105	6	one	one	CD
cord-006860-a3b8hyyr	2105	7	time	time	NN
cord-006860-a3b8hyyr	2105	8	(	(	-LRB-
cord-006860-a3b8hyyr	2105	9	between	between	IN
cord-006860-a3b8hyyr	2105	10	12	12	CD
cord-006860-a3b8hyyr	2105	11	to	to	TO
cord-006860-a3b8hyyr	2105	12	24	24	CD
cord-006860-a3b8hyyr	2105	13	hrs	hrs	NN
cord-006860-a3b8hyyr	2105	14	)	)	-RRB-
cord-006860-a3b8hyyr	2106	1	after	after	IN
cord-006860-a3b8hyyr	2106	2	Haemoctin	Haemoctin	NNP
cord-006860-a3b8hyyr	2106	3	®	®	POS
cord-006860-a3b8hyyr	2106	4	application	application	NN
cord-006860-a3b8hyyr	2106	5	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	2106	6	the	the	DT
cord-006860-a3b8hyyr	2106	7	expected	expect	VBN
cord-006860-a3b8hyyr	2106	8	recovery	recovery	NN
cord-006860-a3b8hyyr	2106	9	and	and	CC
cord-006860-a3b8hyyr	2106	10	normal	normal	JJ
cord-006860-a3b8hyyr	2106	11	half	half	JJ
cord-006860-a3b8hyyr	2106	12	life	life	NN
cord-006860-a3b8hyyr	2106	13	time	time	NN
cord-006860-a3b8hyyr	2106	14	.	.	.
cord-006860-a3b8hyyr	2107	1	None	none	NN
cord-006860-a3b8hyyr	2107	2	of	of	IN
cord-006860-a3b8hyyr	2107	3	the	the	DT
cord-006860-a3b8hyyr	2107	4	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2108	1	A	a	DT
cord-006860-a3b8hyyr	2108	2	patients	patient	NNS
cord-006860-a3b8hyyr	2108	3	,	,	,
cord-006860-a3b8hyyr	2108	4	treated	treat	VBN
cord-006860-a3b8hyyr	2108	5	with	with	IN
cord-006860-a3b8hyyr	2108	6	Haemuetin	Haemuetin	NNP
cord-006860-a3b8hyyr	2108	7	®	®	POS
cord-006860-a3b8hyyr	2108	8	SDH	SDH	NNP
cord-006860-a3b8hyyr	2108	9	developed	develop	VBD
cord-006860-a3b8hyyr	2108	10	a	a	DT
cord-006860-a3b8hyyr	2108	11	clinical	clinical	JJ
cord-006860-a3b8hyyr	2108	12	relevant	relevant	JJ
cord-006860-a3b8hyyr	2108	13	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2108	14	.	.	.
cord-006860-a3b8hyyr	2109	1	At	at	IN
cord-006860-a3b8hyyr	2109	2	the	the	DT
cord-006860-a3b8hyyr	2109	3	beginning	beginning	NN
cord-006860-a3b8hyyr	2109	4	of	of	IN
cord-006860-a3b8hyyr	2109	5	the	the	DT
cord-006860-a3b8hyyr	2109	6	stud	stud	NN
cord-006860-a3b8hyyr	2109	7	)	)	-RRB-
cord-006860-a3b8hyyr	2109	8	'	'	''
cord-006860-a3b8hyyr	2109	9	,	,	,
cord-006860-a3b8hyyr	2109	10	the	the	DT
cord-006860-a3b8hyyr	2109	11	clinical	clinical	JJ
cord-006860-a3b8hyyr	2109	12	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2109	13	of	of	IN
cord-006860-a3b8hyyr	2109	14	Haemuetin	Haemuetin	NNP
cord-006860-a3b8hyyr	2109	15	®	®	,
cord-006860-a3b8hyyr	2109	16	was	be	VBD
cord-006860-a3b8hyyr	2109	17	studied	study	VBN
cord-006860-a3b8hyyr	2109	18	in	in	IN
cord-006860-a3b8hyyr	2109	19	16	16	CD
cord-006860-a3b8hyyr	2109	20	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2109	21	A	a	DT
cord-006860-a3b8hyyr	2109	22	patients	patient	NNS
cord-006860-a3b8hyyr	2109	23	and	and	CC
cord-006860-a3b8hyyr	2109	24	shown	show	VBN
cord-006860-a3b8hyyr	2109	25	to	to	TO
cord-006860-a3b8hyyr	2109	26	give	give	VB
cord-006860-a3b8hyyr	2109	27	an	an	DT
cord-006860-a3b8hyyr	2109	28	in	in	IN
cord-006860-a3b8hyyr	2109	29	vivo	vivo	NN
cord-006860-a3b8hyyr	2109	30	recovery	recovery	NN
cord-006860-a3b8hyyr	2109	31	of	of	IN
cord-006860-a3b8hyyr	2109	32	71	71	CD
cord-006860-a3b8hyyr	2109	33	+	+	SYM
cord-006860-a3b8hyyr	2109	34	15	15	CD
cord-006860-a3b8hyyr	2109	35	%	%	NN
cord-006860-a3b8hyyr	2109	36	by	by	IN
cord-006860-a3b8hyyr	2109	37	one	one	CD
cord-006860-a3b8hyyr	2109	38	stage	stage	NN
cord-006860-a3b8hyyr	2109	39	assay	assay	NN
cord-006860-a3b8hyyr	2109	40	and	and	CC
cord-006860-a3b8hyyr	2109	41	77	77	CD
cord-006860-a3b8hyyr	2109	42	+	+	SYM
cord-006860-a3b8hyyr	2109	43	17	17	CD
cord-006860-a3b8hyyr	2109	44	%	%	NN
cord-006860-a3b8hyyr	2109	45	by	by	IN
cord-006860-a3b8hyyr	2109	46	a	a	DT
cord-006860-a3b8hyyr	2109	47	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	2109	48	assay	assay	NN
cord-006860-a3b8hyyr	2109	49	.	.	.
cord-006860-a3b8hyyr	2110	1	T	T	NNP
cord-006860-a3b8hyyr	2110	2	½	½	CD
cord-006860-a3b8hyyr	2110	3	values	value	NNS
cord-006860-a3b8hyyr	2110	4	were	be	VBD
cord-006860-a3b8hyyr	2110	5	13	13	CD
cord-006860-a3b8hyyr	2110	6	+	+	SYM
cord-006860-a3b8hyyr	2110	7	2.8	2.8	CD
cord-006860-a3b8hyyr	2110	8	and	and	CC
cord-006860-a3b8hyyr	2110	9	12.7	12.7	CD
cord-006860-a3b8hyyr	2110	10	+	+	SYM
cord-006860-a3b8hyyr	2110	11	3.2	3.2	CD
cord-006860-a3b8hyyr	2110	12	hrs	hrs	NN
cord-006860-a3b8hyyr	2110	13	respectively	respectively	RB
cord-006860-a3b8hyyr	2110	14	.	.	.
cord-006860-a3b8hyyr	2111	1	The	the	DT
cord-006860-a3b8hyyr	2111	2	study	study	NN
cord-006860-a3b8hyyr	2111	3	for	for	IN
cord-006860-a3b8hyyr	2111	4	the	the	DT
cord-006860-a3b8hyyr	2111	5	clinical	clinical	JJ
cord-006860-a3b8hyyr	2111	6	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2111	7	of	of	IN
cord-006860-a3b8hyyr	2111	8	Haemoctin	Haemoctin	NNP
cord-006860-a3b8hyyr	2112	1	®	®	.
cord-006860-a3b8hyyr	2113	1	SDH	SDH	NNP
cord-006860-a3b8hyyr	2113	2	was	be	VBD
cord-006860-a3b8hyyr	2113	3	repeated	repeat	VBN
cord-006860-a3b8hyyr	2113	4	in	in	IN
cord-006860-a3b8hyyr	2113	5	a	a	DT
cord-006860-a3b8hyyr	2113	6	group	group	NN
cord-006860-a3b8hyyr	2113	7	of	of	IN
cord-006860-a3b8hyyr	2113	8	6	6	CD
cord-006860-a3b8hyyr	2113	9	patients	patient	NNS
cord-006860-a3b8hyyr	2113	10	approximately	approximately	RB
cord-006860-a3b8hyyr	2113	11	two	two	CD
cord-006860-a3b8hyyr	2113	12	years	year	NNS
cord-006860-a3b8hyyr	2113	13	later	later	RB
cord-006860-a3b8hyyr	2113	14	.	.	.
cord-006860-a3b8hyyr	2114	1	Although	although	IN
cord-006860-a3b8hyyr	2114	2	CD4	CD4	NNP
cord-006860-a3b8hyyr	2114	3	lymphocyte	lymphocyte	NN
cord-006860-a3b8hyyr	2114	4	counts	count	NNS
cord-006860-a3b8hyyr	2114	5	are	be	VBP
cord-006860-a3b8hyyr	2114	6	known	know	VBN
cord-006860-a3b8hyyr	2114	7	as	as	IN
cord-006860-a3b8hyyr	2114	8	reasonable	reasonable	JJ
cord-006860-a3b8hyyr	2114	9	predictors	predictor	NNS
cord-006860-a3b8hyyr	2114	10	of	of	IN
cord-006860-a3b8hyyr	2114	11	prognosis	prognosis	NN
cord-006860-a3b8hyyr	2114	12	in	in	IN
cord-006860-a3b8hyyr	2114	13	HIV	HIV	NNP
cord-006860-a3b8hyyr	2114	14	infection	infection	NN
cord-006860-a3b8hyyr	2114	15	,	,	,
cord-006860-a3b8hyyr	2114	16	the	the	DT
cord-006860-a3b8hyyr	2114	17	CD4	CD4	NNP
cord-006860-a3b8hyyr	2114	18	count	count	NN
cord-006860-a3b8hyyr	2114	19	is	be	VBZ
cord-006860-a3b8hyyr	2114	20	not	not	RB
cord-006860-a3b8hyyr	2114	21	in	in	IN
cord-006860-a3b8hyyr	2114	22	all	all	DT
cord-006860-a3b8hyyr	2114	23	cases	case	NNS
cord-006860-a3b8hyyr	2114	24	an	an	DT
cord-006860-a3b8hyyr	2114	25	infallible	infallible	JJ
cord-006860-a3b8hyyr	2114	26	indicator	indicator	NN
cord-006860-a3b8hyyr	2114	27	of	of	IN
cord-006860-a3b8hyyr	2114	28	prognosis	prognosis	NN
cord-006860-a3b8hyyr	2114	29	.	.	.
cord-006860-a3b8hyyr	2115	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	2115	2	several	several	JJ
cord-006860-a3b8hyyr	2115	3	serological	serological	JJ
cord-006860-a3b8hyyr	2115	4	markers	marker	NNS
cord-006860-a3b8hyyr	2115	5	are	be	VBP
cord-006860-a3b8hyyr	2115	6	used	use	VBN
cord-006860-a3b8hyyr	2115	7	to	to	TO
cord-006860-a3b8hyyr	2115	8	predict	predict	VB
cord-006860-a3b8hyyr	2115	9	disease	disease	NN
cord-006860-a3b8hyyr	2115	10	outcome	outcome	NN
cord-006860-a3b8hyyr	2115	11	,	,	,
cord-006860-a3b8hyyr	2115	12	including	include	VBG
cord-006860-a3b8hyyr	2115	13	beta-2	beta-2	NN
cord-006860-a3b8hyyr	2115	14	microglobulin	microglobulin	NN
cord-006860-a3b8hyyr	2115	15	(	(	-LRB-
cord-006860-a3b8hyyr	2115	16	132	132	CD
cord-006860-a3b8hyyr	2115	17	m	m	NN
cord-006860-a3b8hyyr	2115	18	)	)	-RRB-
cord-006860-a3b8hyyr	2115	19	,	,	,
cord-006860-a3b8hyyr	2115	20	immunoglobulin	immunoglobulin	NN
cord-006860-a3b8hyyr	2115	21	A	A	NNP
cord-006860-a3b8hyyr	2115	22	(	(	-LRB-
cord-006860-a3b8hyyr	2115	23	IgA	IgA	NNP
cord-006860-a3b8hyyr	2115	24	)	)	-RRB-
cord-006860-a3b8hyyr	2115	25	,	,	,
cord-006860-a3b8hyyr	2115	26	lymphocyte	lymphocyte	NN
cord-006860-a3b8hyyr	2115	27	counts	count	NNS
cord-006860-a3b8hyyr	2115	28	(	(	-LRB-
cord-006860-a3b8hyyr	2115	29	lymph	lymph	NN
cord-006860-a3b8hyyr	2115	30	)	)	-RRB-
cord-006860-a3b8hyyr	2115	31	and	and	CC
cord-006860-a3b8hyyr	2115	32	others	other	NNS
cord-006860-a3b8hyyr	2115	33	.	.	.
cord-006860-a3b8hyyr	2116	1	In	in	IN
cord-006860-a3b8hyyr	2116	2	this	this	DT
cord-006860-a3b8hyyr	2116	3	study	study	NN
cord-006860-a3b8hyyr	2116	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	2116	5	followed	follow	VBD
cord-006860-a3b8hyyr	2116	6	a	a	DT
cord-006860-a3b8hyyr	2116	7	cohort	cohort	NN
cord-006860-a3b8hyyr	2116	8	of	of	IN
cord-006860-a3b8hyyr	2116	9	23	23	CD
cord-006860-a3b8hyyr	2116	10	haemophiliacs	haemophiliac	NNS
cord-006860-a3b8hyyr	2116	11	(	(	-LRB-
cord-006860-a3b8hyyr	2116	12	19	19	CD
cord-006860-a3b8hyyr	2116	13	with	with	IN
cord-006860-a3b8hyyr	2116	14	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	2116	15	A	A	NNP
cord-006860-a3b8hyyr	2116	16	,	,	,
cord-006860-a3b8hyyr	2116	17	4	4	CD
cord-006860-a3b8hyyr	2116	18	with	with	IN
cord-006860-a3b8hyyr	2116	19	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	2116	20	B	B	NNP
cord-006860-a3b8hyyr	2116	21	)	)	-RRB-
cord-006860-a3b8hyyr	2116	22	and	and	CC
cord-006860-a3b8hyyr	2116	23	2	2	CD
cord-006860-a3b8hyyr	2116	24	patients	patient	NNS
cord-006860-a3b8hyyr	2116	25	with	with	IN
cord-006860-a3b8hyyr	2116	26	severe	severe	JJ
cord-006860-a3b8hyyr	2116	27	von	von	NNP
cord-006860-a3b8hyyr	2116	28	Willebrands	Willebrands	NNP
cord-006860-a3b8hyyr	2116	29	disease	disease	NN
cord-006860-a3b8hyyr	2116	30	over	over	IN
cord-006860-a3b8hyyr	2116	31	a	a	DT
cord-006860-a3b8hyyr	2116	32	period	period	NN
cord-006860-a3b8hyyr	2116	33	of	of	IN
cord-006860-a3b8hyyr	2116	34	28	28	CD
cord-006860-a3b8hyyr	2116	35	months	month	NNS
cord-006860-a3b8hyyr	2116	36	(	(	-LRB-
cord-006860-a3b8hyyr	2116	37	mean	mean	UH
cord-006860-a3b8hyyr	2116	38	,	,	,
cord-006860-a3b8hyyr	2116	39	range	range	NN
cord-006860-a3b8hyyr	2116	40	:	:	:
cord-006860-a3b8hyyr	2116	41	22	22	CD
cord-006860-a3b8hyyr	2116	42	-	-	SYM
cord-006860-a3b8hyyr	2116	43	34	34	CD
cord-006860-a3b8hyyr	2116	44	)	)	-RRB-
cord-006860-a3b8hyyr	2116	45	.	.	.
cord-006860-a3b8hyyr	2117	1	Testing	test	VBG
cord-006860-a3b8hyyr	2117	2	for	for	IN
cord-006860-a3b8hyyr	2117	3	l~2	l~2	NNP
cord-006860-a3b8hyyr	2117	4	m	m	NNP
cord-006860-a3b8hyyr	2117	5	,	,	,
cord-006860-a3b8hyyr	2117	6	IgG	IgG	NNP
cord-006860-a3b8hyyr	2117	7	,	,	,
cord-006860-a3b8hyyr	2117	8	IgA	IgA	NNP
cord-006860-a3b8hyyr	2117	9	,	,	,
cord-006860-a3b8hyyr	2117	10	IgM	IgM	NNP
cord-006860-a3b8hyyr	2117	11	,	,	,
cord-006860-a3b8hyyr	2117	12	CD4	CD4	NNP
cord-006860-a3b8hyyr	2117	13	and	and	CC
cord-006860-a3b8hyyr	2117	14	CD8	CD8	NNP
cord-006860-a3b8hyyr	2117	15	cell	cell	NN
cord-006860-a3b8hyyr	2117	16	counts	count	NNS
cord-006860-a3b8hyyr	2117	17	(	(	-LRB-
cord-006860-a3b8hyyr	2117	18	abs	abs	UH
cord-006860-a3b8hyyr	2117	19	.	.	.
cord-006860-a3b8hyyr	2117	20	and	and	CC
cord-006860-a3b8hyyr	2117	21	relat	relat	NNP
cord-006860-a3b8hyyr	2117	22	.	.	.
cord-006860-a3b8hyyr	2117	23	)	)	-RRB-
cord-006860-a3b8hyyr	2117	24	,	,	,
cord-006860-a3b8hyyr	2117	25	CD4	CD4	NNP
cord-006860-a3b8hyyr	2117	26	/	/	SYM
cord-006860-a3b8hyyr	2117	27	CD8	CD8	NNP
cord-006860-a3b8hyyr	2117	28	ratio	ratio	NN
cord-006860-a3b8hyyr	2117	29	,	,	,
cord-006860-a3b8hyyr	2117	30	and	and	CC
cord-006860-a3b8hyyr	2117	31	absolute	absolute	JJ
cord-006860-a3b8hyyr	2117	32	resp	resp	NN
cord-006860-a3b8hyyr	2117	33	.	.	.
cord-006860-a3b8hyyr	2118	1	relative	relative	JJ
cord-006860-a3b8hyyr	2118	2	leucocyte	leucocyte	NNP
cord-006860-a3b8hyyr	2118	3	and	and	CC
cord-006860-a3b8hyyr	2118	4	lymphocyte	lymphocyte	NN
cord-006860-a3b8hyyr	2118	5	counts	count	NNS
cord-006860-a3b8hyyr	2118	6	was	be	VBD
cord-006860-a3b8hyyr	2118	7	performed	perform	VBN
cord-006860-a3b8hyyr	2118	8	at	at	IN
cord-006860-a3b8hyyr	2118	9	least	least	JJS
cord-006860-a3b8hyyr	2118	10	3	3	CD
cord-006860-a3b8hyyr	2118	11	times	time	NNS
cord-006860-a3b8hyyr	2118	12	a	a	DT
cord-006860-a3b8hyyr	2118	13	year	year	NN
cord-006860-a3b8hyyr	2118	14	.	.	.
cord-006860-a3b8hyyr	2119	1	At	at	IN
cord-006860-a3b8hyyr	2119	2	the	the	DT
cord-006860-a3b8hyyr	2119	3	same	same	JJ
cord-006860-a3b8hyyr	2119	4	time	time	NN
cord-006860-a3b8hyyr	2119	5	clinical	clinical	JJ
cord-006860-a3b8hyyr	2119	6	examinations	examination	NNS
cord-006860-a3b8hyyr	2119	7	and	and	CC
cord-006860-a3b8hyyr	2119	8	review	review	NN
cord-006860-a3b8hyyr	2119	9	of	of	IN
cord-006860-a3b8hyyr	2119	10	history	history	NN
cord-006860-a3b8hyyr	2119	11	were	be	VBD
cord-006860-a3b8hyyr	2119	12	undertaken	undertake	VBN
cord-006860-a3b8hyyr	2119	13	.	.	.
cord-006860-a3b8hyyr	2120	1	Mean	mean	JJ
cord-006860-a3b8hyyr	2120	2	of	of	IN
cord-006860-a3b8hyyr	2120	3	laboratory	laboratory	NN
cord-006860-a3b8hyyr	2120	4	tests	test	NNS
cord-006860-a3b8hyyr	2120	5	for	for	IN
cord-006860-a3b8hyyr	2120	6	every	every	DT
cord-006860-a3b8hyyr	2120	7	quarter	quarter	NN
cord-006860-a3b8hyyr	2120	8	of	of	IN
cord-006860-a3b8hyyr	2120	9	a	a	DT
cord-006860-a3b8hyyr	2120	10	year	year	NN
cord-006860-a3b8hyyr	2120	11	and	and	CC
cord-006860-a3b8hyyr	2120	12	significant	significant	JJ
cord-006860-a3b8hyyr	2120	13	changes	change	NNS
cord-006860-a3b8hyyr	2120	14	during	during	IN
cord-006860-a3b8hyyr	2120	15	time	time	NN
cord-006860-a3b8hyyr	2120	16	of	of	IN
cord-006860-a3b8hyyr	2120	17	observation	observation	NN
cord-006860-a3b8hyyr	2120	18	were	be	VBD
cord-006860-a3b8hyyr	2120	19	calculated	calculate	VBN
cord-006860-a3b8hyyr	2120	20	and	and	CC
cord-006860-a3b8hyyr	2120	21	correlated	correlate	VBN
cord-006860-a3b8hyyr	2120	22	with	with	IN
cord-006860-a3b8hyyr	2120	23	clinical	clinical	JJ
cord-006860-a3b8hyyr	2120	24	data	datum	NNS
cord-006860-a3b8hyyr	2120	25	.	.	.
cord-006860-a3b8hyyr	2121	1	1	1	LS
cord-006860-a3b8hyyr	2121	2	-	-	SYM
cord-006860-a3b8hyyr	2121	3	4	4	CD
cord-006860-a3b8hyyr	2121	4	5	5	CD
cord-006860-a3b8hyyr	2121	5	-	-	SYM
cord-006860-a3b8hyyr	2121	6	8	8	CD
cord-006860-a3b8hyyr	2121	7	9	9	CD
cord-006860-a3b8hyyr	2121	8	-	-	SYM
cord-006860-a3b8hyyr	2121	9	12	12	CD
cord-006860-a3b8hyyr	2121	10	13	13	CD
cord-006860-a3b8hyyr	2121	11	-	-	SYM
cord-006860-a3b8hyyr	2121	12	16	16	CD
cord-006860-a3b8hyyr	2121	13	17	17	CD
cord-006860-a3b8hyyr	2121	14	-	-	SYM
cord-006860-a3b8hyyr	2121	15	20	20	CD
cord-006860-a3b8hyyr	2121	16	21	21	CD
cord-006860-a3b8hyyr	2121	17	-	-	SYM
cord-006860-a3b8hyyr	2121	18	24	24	CD
cord-006860-a3b8hyyr	2121	19	CD41	CD41	NNP
cord-006860-a3b8hyyr	2121	20	440	440	CD
cord-006860-a3b8hyyr	2121	21	+	+	SYM
cord-006860-a3b8hyyr	2121	22	956	956	CD
cord-006860-a3b8hyyr	2121	23	344	344	CD
cord-006860-a3b8hyyr	2121	24	+	+	CD
cord-006860-a3b8hyyr	2122	1	924	924	CD
cord-006860-a3b8hyyr	2122	2	278	278	CD
cord-006860-a3b8hyyr	2122	3	+	+	CD
cord-006860-a3b8hyyr	2123	1	925	925	CD
cord-006860-a3b8hyyr	2123	2	302.-1:240	302.-1:240	.
cord-006860-a3b8hyyr	2124	1	273.+.220	273.+.220	CD
cord-006860-a3b8hyyr	2124	2	166	166	CD
cord-006860-a3b8hyyr	2124	3	+	+	CC
cord-006860-a3b8hyyr	2125	1	125	125	CD
cord-006860-a3b8hyyr	2125	2	CD8	CD8	NNP
cord-006860-a3b8hyyr	2125	3	~	~	NFP
cord-006860-a3b8hyyr	2125	4	1165	1165	CD
cord-006860-a3b8hyyr	2125	5	+	+	SYM
cord-006860-a3b8hyyr	2125	6	474	474	CD
cord-006860-a3b8hyyr	2125	7	1171	1171	CD
cord-006860-a3b8hyyr	2125	8	+	+	SYM
cord-006860-a3b8hyyr	2125	9	523	523	CD
cord-006860-a3b8hyyr	2125	10	1236	1236	CD
cord-006860-a3b8hyyr	2125	11	+	+	CD
cord-006860-a3b8hyyr	2126	1	1187	1187	CD
cord-006860-a3b8hyyr	2126	2	1017	1017	CD
cord-006860-a3b8hyyr	2126	3	+	+	CC
cord-006860-a3b8hyyr	2127	1	439	439	CD
cord-006860-a3b8hyyr	2127	2	930±412	930±412	CD
cord-006860-a3b8hyyr	2127	3	873	873	CD
cord-006860-a3b8hyyr	2127	4	+	+	SYM
cord-006860-a3b8hyyr	2127	5	478	478	CD
cord-006860-a3b8hyyr	2127	6	1~2	1~2	CD
cord-006860-a3b8hyyr	2127	7	m	m	NN
cord-006860-a3b8hyyr	2127	8	z	z	NNP
cord-006860-a3b8hyyr	2127	9	2.0	2.0	CD
cord-006860-a3b8hyyr	2127	10	+	+	SYM
cord-006860-a3b8hyyr	2127	11	0.6	0.6	CD
cord-006860-a3b8hyyr	2127	12	3.0	3.0	CD
cord-006860-a3b8hyyr	2127	13	+	+	SYM
cord-006860-a3b8hyyr	2127	14	1.0	1.0	CD
cord-006860-a3b8hyyr	2127	15	3.0	3.0	CD
cord-006860-a3b8hyyr	2127	16	+	+	SYM
cord-006860-a3b8hyyr	2127	17	1.2	1.2	CD
cord-006860-a3b8hyyr	2127	18	3.0	3.0	CD
cord-006860-a3b8hyyr	2127	19	+	+	CC
cord-006860-a3b8hyyr	2128	1	1.1	1.1	CD
cord-006860-a3b8hyyr	2128	2	3.5±1.0	3.5±1.0	CD
cord-006860-a3b8hyyr	2128	3	3.5±1.3	3.5±1.3	CD
cord-006860-a3b8hyyr	2128	4	lymph	lymph	NN
cord-006860-a3b8hyyr	2128	5	~	~	NFP
cord-006860-a3b8hyyr	2129	1	1.98	1.98	CD
cord-006860-a3b8hyyr	2129	2	+	+	SYM
cord-006860-a3b8hyyr	2129	3	0.6	0.6	CD
cord-006860-a3b8hyyr	2129	4	1.83	1.83	CD
cord-006860-a3b8hyyr	2129	5	+	+	SYM
cord-006860-a3b8hyyr	2129	6	0.6	0.6	CD
cord-006860-a3b8hyyr	2129	7	1.72	1.72	CD
cord-006860-a3b8hyyr	2129	8	+	+	SYM
cord-006860-a3b8hyyr	2129	9	0.7	0.7	CD
cord-006860-a3b8hyyr	2129	10	1.67±0.6	1.67±0.6	CD
cord-006860-a3b8hyyr	2129	11	1.46±0.6	1.46±0.6	CD
cord-006860-a3b8hyyr	2129	12	1.31±0.5	1.31±0.5	CD
cord-006860-a3b8hyyr	2130	1	means/	means/	CD
cord-006860-a3b8hyyr	2131	1	pL	pL	NNP
cord-006860-a3b8hyyr	2131	2	±	±	CD
cord-006860-a3b8hyyr	2131	3	standard	standard	JJ
cord-006860-a3b8hyyr	2131	4	deviation	deviation	NN
cord-006860-a3b8hyyr	2131	5	means	mean	VBZ
cord-006860-a3b8hyyr	2131	6	mg	mg	NNP
cord-006860-a3b8hyyr	2131	7	/	/	SYM
cord-006860-a3b8hyyr	2131	8	L	L	NNP
cord-006860-a3b8hyyr	2131	9	±	±	NNP
cord-006860-a3b8hyyr	2131	10	standard	standard	JJ
cord-006860-a3b8hyyr	2131	11	deviation	deviation	NN
cord-006860-a3b8hyyr	2131	12	During	during	IN
cord-006860-a3b8hyyr	2131	13	time	time	NN
cord-006860-a3b8hyyr	2132	1	ef	ef	NNP
cord-006860-a3b8hyyr	2132	2	observation	observation	NN
cord-006860-a3b8hyyr	2133	1	we	-PRON-	PRP
cord-006860-a3b8hyyr	2133	2	found	find	VBD
cord-006860-a3b8hyyr	2133	3	significant	significant	JJ
cord-006860-a3b8hyyr	2133	4	changes	change	NNS
cord-006860-a3b8hyyr	2133	5	of	of	IN
cord-006860-a3b8hyyr	2133	6	CD4	CD4	NNP
cord-006860-a3b8hyyr	2133	7	(	(	-LRB-
cord-006860-a3b8hyyr	2133	8	abs	abs	NNP
cord-006860-a3b8hyyr	2133	9	.	.	.
cord-006860-a3b8hyyr	2133	10	and	and	CC
cord-006860-a3b8hyyr	2133	11	relat	relat	NNP
cord-006860-a3b8hyyr	2133	12	.	.	.
cord-006860-a3b8hyyr	2133	13	)	)	-RRB-
cord-006860-a3b8hyyr	2133	14	,	,	.
cord-006860-a3b8hyyr	2134	1	abs	abs	NNP
cord-006860-a3b8hyyr	2134	2	.	.	.
cord-006860-a3b8hyyr	2135	1	CD8	CD8	NNP
cord-006860-a3b8hyyr	2135	2	counts	count	VBZ
cord-006860-a3b8hyyr	2135	3	,	,	,
cord-006860-a3b8hyyr	2135	4	CD4	CD4	NNP
cord-006860-a3b8hyyr	2135	5	/	/	SYM
cord-006860-a3b8hyyr	2135	6	CD8	CD8	NNP
cord-006860-a3b8hyyr	2135	7	ratio	ratio	NN
cord-006860-a3b8hyyr	2135	8	,	,	,
cord-006860-a3b8hyyr	2136	1	f~2	f~2	NNP
cord-006860-a3b8hyyr	2136	2	m	m	NNP
cord-006860-a3b8hyyr	2136	3	,	,	,
cord-006860-a3b8hyyr	2136	4	leucocytes	leucocytes	NNP
cord-006860-a3b8hyyr	2136	5	and	and	CC
cord-006860-a3b8hyyr	2136	6	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	2136	7	.	.	.
cord-006860-a3b8hyyr	2137	1	The	the	DT
cord-006860-a3b8hyyr	2137	2	abs	abs	NN
cord-006860-a3b8hyyr	2137	3	.	.	.
cord-006860-a3b8hyyr	2138	1	CD4	CD4	NNP
cord-006860-a3b8hyyr	2138	2	and	and	CC
cord-006860-a3b8hyyr	2138	3	CD8	CD8	NNP
cord-006860-a3b8hyyr	2138	4	counts	count	VBZ
cord-006860-a3b8hyyr	2138	5	correlated	correlate	VBD
cord-006860-a3b8hyyr	2138	6	clearly	clearly	RB
cord-006860-a3b8hyyr	2138	7	with	with	IN
cord-006860-a3b8hyyr	2138	8	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	2139	1	und	und	NNP
cord-006860-a3b8hyyr	2139	2	leucocytes	leucocytes	NNP
cord-006860-a3b8hyyr	2139	3	counts	count	VBZ
cord-006860-a3b8hyyr	2139	4	but	but	CC
cord-006860-a3b8hyyr	2139	5	not	not	RB
cord-006860-a3b8hyyr	2139	6	with	with	IN
cord-006860-a3b8hyyr	2139	7	1~2	1~2	CD
cord-006860-a3b8hyyr	2139	8	m	m	NN
cord-006860-a3b8hyyr	2139	9	.	.	.
cord-006860-a3b8hyyr	2140	1	The	the	DT
cord-006860-a3b8hyyr	2140	2	prognostic	prognostic	JJ
cord-006860-a3b8hyyr	2140	3	value	value	NN
cord-006860-a3b8hyyr	2140	4	of	of	IN
cord-006860-a3b8hyyr	2140	5	the	the	DT
cord-006860-a3b8hyyr	2140	6	tested	test	VBN
cord-006860-a3b8hyyr	2140	7	parameters	parameter	NNS
cord-006860-a3b8hyyr	2140	8	is	be	VBZ
cord-006860-a3b8hyyr	2140	9	discussed	discuss	VBN
cord-006860-a3b8hyyr	2140	10	by	by	IN
cord-006860-a3b8hyyr	2140	11	calculation	calculation	NN
cord-006860-a3b8hyyr	2140	12	of	of	IN
cord-006860-a3b8hyyr	2140	13	correlations	correlation	NNS
cord-006860-a3b8hyyr	2140	14	with	with	IN
cord-006860-a3b8hyyr	2140	15	clinical	clinical	JJ
cord-006860-a3b8hyyr	2140	16	data	datum	NNS
cord-006860-a3b8hyyr	2140	17	,	,	,
cord-006860-a3b8hyyr	2140	18	anti	anti	JJ
cord-006860-a3b8hyyr	2140	19	-	-	JJ
cord-006860-a3b8hyyr	2140	20	retroviral	retroviral	JJ
cord-006860-a3b8hyyr	2140	21	treatment	treatment	NN
cord-006860-a3b8hyyr	2140	22	and	and	CC
cord-006860-a3b8hyyr	2140	23	treatment	treatment	NN
cord-006860-a3b8hyyr	2140	24	of	of	IN
cord-006860-a3b8hyyr	2140	25	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	2140	26	.	.	.
cord-006860-a3b8hyyr	2141	1	The	the	DT
cord-006860-a3b8hyyr	2141	2	availability	availability	NN
cord-006860-a3b8hyyr	2141	3	of	of	IN
cord-006860-a3b8hyyr	2141	4	high	high	JJ
cord-006860-a3b8hyyr	2141	5	purity	purity	NN
cord-006860-a3b8hyyr	2141	6	factor	factor	NN
cord-006860-a3b8hyyr	2141	7	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	2141	8	has	have	VBZ
cord-006860-a3b8hyyr	2141	9	recently	recently	RB
cord-006860-a3b8hyyr	2141	10	encouraged	encourage	VBN
cord-006860-a3b8hyyr	2141	11	clinicians	clinician	NNS
cord-006860-a3b8hyyr	2141	12	to	to	TO
cord-006860-a3b8hyyr	2141	13	use	use	VB
cord-006860-a3b8hyyr	2141	14	perioperative	perioperative	JJ
cord-006860-a3b8hyyr	2141	15	continuous	continuous	JJ
cord-006860-a3b8hyyr	2141	16	infusion	infusion	NN
cord-006860-a3b8hyyr	2141	17	of	of	IN
cord-006860-a3b8hyyr	2141	18	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2141	19	or	or	CC
cord-006860-a3b8hyyr	2141	20	FIX	fix	VB
cord-006860-a3b8hyyr	2141	21	to	to	TO
cord-006860-a3b8hyyr	2141	22	prevent	prevent	VB
cord-006860-a3b8hyyr	2141	23	or	or	CC
cord-006860-a3b8hyyr	2141	24	reduce	reduce	VB
cord-006860-a3b8hyyr	2141	25	bleeding	bleeding	NN
cord-006860-a3b8hyyr	2141	26	in	in	IN
cord-006860-a3b8hyyr	2141	27	patients	patient	NNS
cord-006860-a3b8hyyr	2141	28	with	with	IN
cord-006860-a3b8hyyr	2141	29	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	2141	30	.	.	.
cord-006860-a3b8hyyr	2142	1	In	in	IN
cord-006860-a3b8hyyr	2142	2	conlIast	conliast	JJ
cord-006860-a3b8hyyr	2142	3	to	to	IN
cord-006860-a3b8hyyr	2142	4	repeated	repeat	VBN
cord-006860-a3b8hyyr	2142	5	highdose	highdose	NN
cord-006860-a3b8hyyr	2142	6	bolus	bolus	NN
cord-006860-a3b8hyyr	2142	7	injections	injection	NNS
cord-006860-a3b8hyyr	2142	8	,	,	,
cord-006860-a3b8hyyr	2142	9	the	the	DT
cord-006860-a3b8hyyr	2142	10	continuous	continuous	JJ
cord-006860-a3b8hyyr	2142	11	infusion	infusion	NN
cord-006860-a3b8hyyr	2142	12	trealment	trealment	NN
cord-006860-a3b8hyyr	2142	13	regime	regime	NN
cord-006860-a3b8hyyr	2142	14	maintains	maintain	VBZ
cord-006860-a3b8hyyr	2142	15	constant	constant	JJ
cord-006860-a3b8hyyr	2142	16	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2142	17	factor	factor	NN
cord-006860-a3b8hyyr	2142	18	activity	activity	NN
cord-006860-a3b8hyyr	2142	19	at	at	IN
cord-006860-a3b8hyyr	2142	20	a	a	DT
cord-006860-a3b8hyyr	2142	21	level	level	NN
cord-006860-a3b8hyyr	2142	22	necessary	necessary	JJ
cord-006860-a3b8hyyr	2142	23	for	for	IN
cord-006860-a3b8hyyr	2142	24	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	2142	25	,	,	,
cord-006860-a3b8hyyr	2142	26	reducing	reduce	VBG
cord-006860-a3b8hyyr	2142	27	the	the	DT
cord-006860-a3b8hyyr	2142	28	total	total	JJ
cord-006860-a3b8hyyr	2142	29	cost	cost	NN
cord-006860-a3b8hyyr	2142	30	of	of	IN
cord-006860-a3b8hyyr	2142	31	treatment	treatment	NN
cord-006860-a3b8hyyr	2142	32	by	by	IN
cord-006860-a3b8hyyr	2142	33	about	about	RB
cord-006860-a3b8hyyr	2142	34	20	20	CD
cord-006860-a3b8hyyr	2142	35	%	%	NN
cord-006860-a3b8hyyr	2142	36	and	and	CC
cord-006860-a3b8hyyr	2142	37	preventing	prevent	VBG
cord-006860-a3b8hyyr	2142	38	possible	possible	JJ
cord-006860-a3b8hyyr	2142	39	side	side	NN
cord-006860-a3b8hyyr	2142	40	effects	effect	NNS
cord-006860-a3b8hyyr	2142	41	of	of	IN
cord-006860-a3b8hyyr	2142	42	bolus	bolus	NN
cord-006860-a3b8hyyr	2142	43	doses	dose	NNS
cord-006860-a3b8hyyr	2142	44	.	.	.
cord-006860-a3b8hyyr	2143	1	The	the	DT
cord-006860-a3b8hyyr	2143	2	new	new	JJ
cord-006860-a3b8hyyr	2143	3	application	application	NN
cord-006860-a3b8hyyr	2143	4	mode	mode	NN
cord-006860-a3b8hyyr	2143	5	,	,	,
cord-006860-a3b8hyyr	2143	6	however	however	RB
cord-006860-a3b8hyyr	2143	7	,	,	,
cord-006860-a3b8hyyr	2143	8	requires	require	VBZ
cord-006860-a3b8hyyr	2143	9	stable	stable	JJ
cord-006860-a3b8hyyr	2143	10	products	product	NNS
cord-006860-a3b8hyyr	2143	11	which	which	WDT
cord-006860-a3b8hyyr	2143	12	tolerate	tolerate	VBP
cord-006860-a3b8hyyr	2143	13	slow	slow	JJ
cord-006860-a3b8hyyr	2143	14	passage	passage	NN
cord-006860-a3b8hyyr	2143	15	through	through	IN
cord-006860-a3b8hyyr	2143	16	an	an	DT
cord-006860-a3b8hyyr	2143	17	infusion	infusion	NN
cord-006860-a3b8hyyr	2143	18	device	device	NN
cord-006860-a3b8hyyr	2143	19	.	.	.
cord-006860-a3b8hyyr	2144	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	2144	2	objective	objective	NN
cord-006860-a3b8hyyr	2144	3	was	be	VBD
cord-006860-a3b8hyyr	2144	4	to	to	TO
cord-006860-a3b8hyyr	2144	5	test	test	VB
cord-006860-a3b8hyyr	2144	6	in	in	IN
cord-006860-a3b8hyyr	2144	7	vitro	vitro	FW
cord-006860-a3b8hyyr	2144	8	the	the	DT
cord-006860-a3b8hyyr	2144	9	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2144	10	concentrate	concentrate	VBP
cord-006860-a3b8hyyr	2144	11	IMMUNATE	IMMUNATE	NNP
cord-006860-a3b8hyyr	2144	12	(	(	-LRB-
cord-006860-a3b8hyyr	2144	13	STIM	STIM	NNP
cord-006860-a3b8hyyr	2144	14	plus	plus	NN
cord-006860-a3b8hyyr	2144	15	)	)	-RRB-
cord-006860-a3b8hyyr	2144	16	and	and	CC
cord-006860-a3b8hyyr	2144	17	the	the	DT
cord-006860-a3b8hyyr	2144	18	FIX	fix	NN
cord-006860-a3b8hyyr	2144	19	concentrate	concentrate	VBP
cord-006860-a3b8hyyr	2144	20	IMMI.YNINE	IMMI.YNINE	NNP
cord-006860-a3b8hyyr	2144	21	(	(	-LRB-
cord-006860-a3b8hyyr	2144	22	STIM	STIM	NNP
cord-006860-a3b8hyyr	2144	23	plus	plus	CC
cord-006860-a3b8hyyr	2144	24	)	)	-RRB-
cord-006860-a3b8hyyr	2144	25	at	at	IN
cord-006860-a3b8hyyr	2144	26	room	room	NN
cord-006860-a3b8hyyr	2144	27	temperature	temperature	NN
cord-006860-a3b8hyyr	2144	28	,	,	,
cord-006860-a3b8hyyr	2144	29	under	under	IN
cord-006860-a3b8hyyr	2144	30	conditions	condition	NNS
cord-006860-a3b8hyyr	2144	31	of	of	IN
cord-006860-a3b8hyyr	2144	32	long	long	JJ
cord-006860-a3b8hyyr	2144	33	-	-	HYPH
cord-006860-a3b8hyyr	2144	34	term	term	NN
cord-006860-a3b8hyyr	2144	35	contact	contact	NN
cord-006860-a3b8hyyr	2144	36	with	with	IN
cord-006860-a3b8hyyr	2144	37	polypropylene	polypropylene	NN
cord-006860-a3b8hyyr	2144	38	tubing	tubing	NN
cord-006860-a3b8hyyr	2144	39	in	in	IN
cord-006860-a3b8hyyr	2144	40	an	an	DT
cord-006860-a3b8hyyr	2144	41	infusion	infusion	NN
cord-006860-a3b8hyyr	2144	42	pump	pump	NN
cord-006860-a3b8hyyr	2144	43	.	.	.
cord-006860-a3b8hyyr	2145	1	Infusion	infusion	NN
cord-006860-a3b8hyyr	2145	2	rates	rate	NNS
cord-006860-a3b8hyyr	2145	3	were	be	VBD
cord-006860-a3b8hyyr	2145	4	chosen	choose	VBN
cord-006860-a3b8hyyr	2145	5	to	to	TO
cord-006860-a3b8hyyr	2145	6	mimic	mimic	VB
cord-006860-a3b8hyyr	2145	7	clinical	clinical	JJ
cord-006860-a3b8hyyr	2145	8	situation	situation	NN
cord-006860-a3b8hyyr	2145	9	.	.	.
cord-006860-a3b8hyyr	2146	1	The	the	DT
cord-006860-a3b8hyyr	2146	2	control	control	NN
cord-006860-a3b8hyyr	2146	3	samples	sample	NNS
cord-006860-a3b8hyyr	2146	4	were	be	VBD
cord-006860-a3b8hyyr	2146	5	not	not	RB
cord-006860-a3b8hyyr	2146	6	infused	infuse	VBN
cord-006860-a3b8hyyr	2146	7	through	through	IN
cord-006860-a3b8hyyr	2146	8	the	the	DT
cord-006860-a3b8hyyr	2146	9	pump	pump	NN
cord-006860-a3b8hyyr	2146	10	but	but	CC
cord-006860-a3b8hyyr	2146	11	were	be	VBD
cord-006860-a3b8hyyr	2146	12	otherwise	otherwise	RB
cord-006860-a3b8hyyr	2146	13	treated	treat	VBN
cord-006860-a3b8hyyr	2146	14	identically	identically	RB
cord-006860-a3b8hyyr	2146	15	.	.	.
cord-006860-a3b8hyyr	2147	1	Test	test	NN
cord-006860-a3b8hyyr	2147	2	samples	sample	NNS
cord-006860-a3b8hyyr	2147	3	were	be	VBD
cord-006860-a3b8hyyr	2147	4	drawn	draw	VBN
cord-006860-a3b8hyyr	2147	5	before	before	RB
cord-006860-a3b8hyyr	2147	6	and	and	CC
cord-006860-a3b8hyyr	2147	7	at	at	IN
cord-006860-a3b8hyyr	2147	8	1	1	CD
cord-006860-a3b8hyyr	2147	9	,	,	,
cord-006860-a3b8hyyr	2147	10	4	4	CD
cord-006860-a3b8hyyr	2147	11	,	,	,
cord-006860-a3b8hyyr	2147	12	8	8	CD
cord-006860-a3b8hyyr	2147	13	,	,	,
cord-006860-a3b8hyyr	2147	14	24	24	CD
cord-006860-a3b8hyyr	2147	15	and	and	CC
cord-006860-a3b8hyyr	2147	16	48	48	CD
cord-006860-a3b8hyyr	2147	17	hours	hour	NNS
cord-006860-a3b8hyyr	2147	18	after	after	IN
cord-006860-a3b8hyyr	2147	19	the	the	DT
cord-006860-a3b8hyyr	2147	20	onset	onset	NN
cord-006860-a3b8hyyr	2147	21	of	of	IN
cord-006860-a3b8hyyr	2147	22	each	each	DT
cord-006860-a3b8hyyr	2147	23	infusion	infusion	NN
cord-006860-a3b8hyyr	2147	24	run	run	NN
cord-006860-a3b8hyyr	2147	25	.	.	.
cord-006860-a3b8hyyr	2148	1	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2148	2	(	(	-LRB-
cord-006860-a3b8hyyr	2148	3	one	one	CD
cord-006860-a3b8hyyr	2148	4	-	-	HYPH
cord-006860-a3b8hyyr	2148	5	stage	stage	NN
cord-006860-a3b8hyyr	2148	6	,	,	,
cord-006860-a3b8hyyr	2148	7	two	two	CD
cord-006860-a3b8hyyr	2148	8	-	-	HYPH
cord-006860-a3b8hyyr	2148	9	stage	stage	NN
cord-006860-a3b8hyyr	2148	10	and	and	CC
cord-006860-a3b8hyyr	2148	11	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	2148	12	assay	assay	NN
cord-006860-a3b8hyyr	2148	13	)	)	-RRB-
cord-006860-a3b8hyyr	2148	14	and	and	CC
cord-006860-a3b8hyyr	2148	15	FIX	fix	NN
cord-006860-a3b8hyyr	2148	16	(	(	-LRB-
cord-006860-a3b8hyyr	2149	1	one	one	CD
cord-006860-a3b8hyyr	2149	2	-	-	HYPH
cord-006860-a3b8hyyr	2149	3	stage	stage	NN
cord-006860-a3b8hyyr	2149	4	)	)	-RRB-
cord-006860-a3b8hyyr	2149	5	activity	activity	NN
cord-006860-a3b8hyyr	2149	6	were	be	VBD
cord-006860-a3b8hyyr	2149	7	measured	measure	VBN
cord-006860-a3b8hyyr	2149	8	using	use	VBG
cord-006860-a3b8hyyr	2149	9	IMMUNO	immuno	JJ
cord-006860-a3b8hyyr	2149	10	reagents	reagent	NNS
cord-006860-a3b8hyyr	2149	11	.	.	.
cord-006860-a3b8hyyr	2150	1	Presence	presence	NN
cord-006860-a3b8hyyr	2150	2	of	of	IN
cord-006860-a3b8hyyr	2150	3	activated	activate	VBN
cord-006860-a3b8hyyr	2150	4	factors	factor	NNS
cord-006860-a3b8hyyr	2150	5	were	be	VBD
cord-006860-a3b8hyyr	2150	6	measured	measure	VBN
cord-006860-a3b8hyyr	2150	7	by	by	IN
cord-006860-a3b8hyyr	2150	8	NAPT'I	NAPT'I	NNP
cord-006860-a3b8hyyr	2150	9	'	'	''
cord-006860-a3b8hyyr	2150	10	,	,	,
cord-006860-a3b8hyyr	2150	11	while	while	IN
cord-006860-a3b8hyyr	2150	12	Flla	Flla	NNP
cord-006860-a3b8hyyr	2150	13	,	,	,
cord-006860-a3b8hyyr	2150	14	FXa	FXa	NNPS
cord-006860-a3b8hyyr	2150	15	,	,	,
cord-006860-a3b8hyyr	2150	16	plasmin	plasmin	NNP
cord-006860-a3b8hyyr	2150	17	and	and	CC
cord-006860-a3b8hyyr	2150	18	pre	pre	JJ
cord-006860-a3b8hyyr	2150	19	-	-	JJ
cord-006860-a3b8hyyr	2150	20	kallikrein	kallikrein	JJ
cord-006860-a3b8hyyr	2150	21	activator	activator	NN
cord-006860-a3b8hyyr	2150	22	were	be	VBD
cord-006860-a3b8hyyr	2150	23	detected	detect	VBN
cord-006860-a3b8hyyr	2150	24	with	with	IN
cord-006860-a3b8hyyr	2150	25	specific	specific	JJ
cord-006860-a3b8hyyr	2150	26	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	2150	27	substrates	substrate	NNS
cord-006860-a3b8hyyr	2150	28	.	.	.
cord-006860-a3b8hyyr	2151	1	The	the	DT
cord-006860-a3b8hyyr	2151	2	data	datum	NNS
cord-006860-a3b8hyyr	2151	3	showed	show	VBD
cord-006860-a3b8hyyr	2151	4	equivalent	equivalent	JJ
cord-006860-a3b8hyyr	2151	5	results	result	NNS
cord-006860-a3b8hyyr	2151	6	between	between	IN
cord-006860-a3b8hyyr	2151	7	test	test	NN
cord-006860-a3b8hyyr	2151	8	and	and	CC
cord-006860-a3b8hyyr	2151	9	control	control	NN
cord-006860-a3b8hyyr	2151	10	samples	sample	NNS
cord-006860-a3b8hyyr	2151	11	with	with	IN
cord-006860-a3b8hyyr	2151	12	no	no	DT
cord-006860-a3b8hyyr	2151	13	loss	loss	NN
cord-006860-a3b8hyyr	2151	14	of	of	IN
cord-006860-a3b8hyyr	2151	15	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	2151	16	or	or	CC
cord-006860-a3b8hyyr	2151	17	FIX	fix	VB
cord-006860-a3b8hyyr	2151	18	activity	activity	NN
cord-006860-a3b8hyyr	2151	19	.	.	.
cord-006860-a3b8hyyr	2152	1	The	the	DT
cord-006860-a3b8hyyr	2152	2	potencies	potency	NNS
cord-006860-a3b8hyyr	2152	3	of	of	IN
cord-006860-a3b8hyyr	2152	4	both	both	CC
cord-006860-a3b8hyyr	2152	5	IMMUNATE	IMMUNATE	NNP
cord-006860-a3b8hyyr	2152	6	(	(	-LRB-
cord-006860-a3b8hyyr	2152	7	STIM	STIM	NNP
cord-006860-a3b8hyyr	2152	8	plus	plus	CC
cord-006860-a3b8hyyr	2152	9	)	)	-RRB-
cord-006860-a3b8hyyr	2152	10	and	and	CC
cord-006860-a3b8hyyr	2152	11	IMMUNINE	IMMUNINE	NNP
cord-006860-a3b8hyyr	2152	12	(	(	-LRB-
cord-006860-a3b8hyyr	2152	13	STIM	STIM	NNP
cord-006860-a3b8hyyr	2152	14	plus	plus	NN
cord-006860-a3b8hyyr	2152	15	)	)	-RRB-
cord-006860-a3b8hyyr	2152	16	remained	remain	VBD
cord-006860-a3b8hyyr	2152	17	within	within	IN
cord-006860-a3b8hyyr	2152	18	100	100	CD
cord-006860-a3b8hyyr	2152	19	+	+	SYM
cord-006860-a3b8hyyr	2152	20	20	20	CD
cord-006860-a3b8hyyr	2152	21	%	%	NN
cord-006860-a3b8hyyr	2152	22	of	of	IN
cord-006860-a3b8hyyr	2152	23	labeUed	labeUed	NNP
cord-006860-a3b8hyyr	2152	24	values	value	NNS
cord-006860-a3b8hyyr	2152	25	within	within	IN
cord-006860-a3b8hyyr	2152	26	48	48	CD
cord-006860-a3b8hyyr	2152	27	hours	hour	NNS
cord-006860-a3b8hyyr	2152	28	after	after	IN
cord-006860-a3b8hyyr	2152	29	onset	onset	NN
cord-006860-a3b8hyyr	2152	30	of	of	IN
cord-006860-a3b8hyyr	2152	31	infusion	infusion	NN
cord-006860-a3b8hyyr	2152	32	.	.	.
cord-006860-a3b8hyyr	2153	1	In	in	IN
cord-006860-a3b8hyyr	2153	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	2153	3	,	,	,
cord-006860-a3b8hyyr	2153	4	IMMUNATE	IMMUNATE	NNP
cord-006860-a3b8hyyr	2153	5	(	(	-LRB-
cord-006860-a3b8hyyr	2153	6	STIM	STIM	NNP
cord-006860-a3b8hyyr	2153	7	plus	plus	CC
cord-006860-a3b8hyyr	2153	8	)	)	-RRB-
cord-006860-a3b8hyyr	2153	9	and	and	CC
cord-006860-a3b8hyyr	2153	10	IMMUNINE	IMMUNINE	NNP
cord-006860-a3b8hyyr	2153	11	(	(	-LRB-
cord-006860-a3b8hyyr	2153	12	ST1	ST1	NNP
cord-006860-a3b8hyyr	2153	13	M	M	NNP
cord-006860-a3b8hyyr	2153	14	plus	plus	CC
cord-006860-a3b8hyyr	2153	15	)	)	-RRB-
cord-006860-a3b8hyyr	2153	16	are	be	VBP
cord-006860-a3b8hyyr	2153	17	suitable	suitable	JJ
cord-006860-a3b8hyyr	2153	18	for	for	IN
cord-006860-a3b8hyyr	2153	19	contiuous	contiuous	JJ
cord-006860-a3b8hyyr	2153	20	infusion	infusion	NN
cord-006860-a3b8hyyr	2153	21	when	when	WRB
cord-006860-a3b8hyyr	2153	22	using	use	VBG
cord-006860-a3b8hyyr	2153	23	automatic	automatic	JJ
cord-006860-a3b8hyyr	2153	24	infusion	infusion	NN
cord-006860-a3b8hyyr	2153	25	device	device	NN
cord-006860-a3b8hyyr	2153	26	within	within	IN
cord-006860-a3b8hyyr	2153	27	applied	apply	VBN
cord-006860-a3b8hyyr	2153	28	test	test	NN
cord-006860-a3b8hyyr	2153	29	criteria	criterion	NNS
cord-006860-a3b8hyyr	2153	30	.	.	.
cord-006860-a3b8hyyr	2154	1	In	in	IN
cord-006860-a3b8hyyr	2154	2	htanans	htanans	NNP
cord-006860-a3b8hyyr	2154	3	,	,	,
cord-006860-a3b8hyyr	2154	4	circulating	circulate	VBG
cord-006860-a3b8hyyr	2154	5	half	half	RB
cord-006860-a3b8hyyr	2154	6	-	-	HYPH
cord-006860-a3b8hyyr	2154	7	lives	life	NNS
cord-006860-a3b8hyyr	2154	8	of	of	IN
cord-006860-a3b8hyyr	2154	9	asparaginase	asparaginase	NN
cord-006860-a3b8hyyr	2154	10	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	2154	11	from	from	IN
cord-006860-a3b8hyyr	2154	12	E.	E.	NNP
cord-006860-a3b8hyyr	2154	13	coli	coli	NNS
cord-006860-a3b8hyyr	2154	14	and	and	CC
cord-006860-a3b8hyyr	2154	15	Erwinia	Erwinia	NNP
cord-006860-a3b8hyyr	2154	16	chrysanthemi	chrysanthemi	NN
cord-006860-a3b8hyyr	2154	17	vary	vary	VBP
cord-006860-a3b8hyyr	2154	18	within	within	IN
cord-006860-a3b8hyyr	2154	19	a	a	DT
cord-006860-a3b8hyyr	2154	20	wide	wide	JJ
cord-006860-a3b8hyyr	2154	21	range	range	NN
cord-006860-a3b8hyyr	2154	22	.	.	.
cord-006860-a3b8hyyr	2155	1	Moreover	moreover	RB
cord-006860-a3b8hyyr	2155	2	,	,	,
cord-006860-a3b8hyyr	2155	3	half	half	RB
cord-006860-a3b8hyyr	2155	4	-	-	HYPH
cord-006860-a3b8hyyr	2155	5	lives	life	NNS
cord-006860-a3b8hyyr	2155	6	differ	differ	VBP
cord-006860-a3b8hyyr	2155	7	not	not	RB
cord-006860-a3b8hyyr	2155	8	only	only	RB
cord-006860-a3b8hyyr	2155	9	among	among	IN
cord-006860-a3b8hyyr	2155	10	different	different	JJ
cord-006860-a3b8hyyr	2155	11	E.	E.	NNP
cord-006860-a3b8hyyr	2155	12	coli	coli	VBZ
cord-006860-a3b8hyyr	2155	13	strains	strain	NNS
cord-006860-a3b8hyyr	2155	14	but	but	CC
cord-006860-a3b8hyyr	2155	15	also	also	RB
cord-006860-a3b8hyyr	2155	16	among	among	IN
cord-006860-a3b8hyyr	2155	17	commercial	commercial	JJ
cord-006860-a3b8hyyr	2155	18	E.	E.	NNP
cord-006860-a3b8hyyr	2155	19	coli	coli	NNS
cord-006860-a3b8hyyr	2155	20	preparations	preparation	NNS
cord-006860-a3b8hyyr	2155	21	.	.	.
cord-006860-a3b8hyyr	2156	1	To	to	TO
cord-006860-a3b8hyyr	2156	2	investigate	investigate	VB
cord-006860-a3b8hyyr	2156	3	the	the	DT
cord-006860-a3b8hyyr	2156	4	possible	possible	JJ
cord-006860-a3b8hyyr	2156	5	influence	influence	NN
cord-006860-a3b8hyyr	2156	6	of	of	IN
cord-006860-a3b8hyyr	2156	7	two	two	CD
cord-006860-a3b8hyyr	2156	8	different	different	JJ
cord-006860-a3b8hyyr	2156	9	sources	source	NNS
cord-006860-a3b8hyyr	2156	10	of	of	IN
cord-006860-a3b8hyyr	2156	11	E.	E.	NNP
cord-006860-a3b8hyyr	2156	12	coil	coil	NN
cord-006860-a3b8hyyr	2156	13	asparagmase	asparagmase	NN
cord-006860-a3b8hyyr	2156	14	(	(	-LRB-
cord-006860-a3b8hyyr	2156	15	ASN	ASN	NNP
cord-006860-a3b8hyyr	2156	16	)	)	-RRB-
cord-006860-a3b8hyyr	2156	17	preparations	preparation	NNS
cord-006860-a3b8hyyr	2156	18	on	on	IN
cord-006860-a3b8hyyr	2156	19	the	the	DT
cord-006860-a3b8hyyr	2156	20	fibfinolytic	fibfinolytic	JJ
cord-006860-a3b8hyyr	2156	21	system	system	NN
cord-006860-a3b8hyyr	2156	22	of	of	IN
cord-006860-a3b8hyyr	2156	23	leukemic	leukemic	JJ
cord-006860-a3b8hyyr	2156	24	children	child	NNS
cord-006860-a3b8hyyr	2156	25	a	a	DT
cord-006860-a3b8hyyr	2156	26	prospective	prospective	JJ
cord-006860-a3b8hyyr	2156	27	randomized	randomized	JJ
cord-006860-a3b8hyyr	2156	28	study	study	NN
cord-006860-a3b8hyyr	2156	29	was	be	VBD
cord-006860-a3b8hyyr	2156	30	performed	perform	VBN
cord-006860-a3b8hyyr	2156	31	correlating	correlate	VBG
cord-006860-a3b8hyyr	2156	32	ASN	asn	NN
cord-006860-a3b8hyyr	2156	33	pharmacokiuetics	pharmacokiuetic	NNS
cord-006860-a3b8hyyr	2156	34	(	(	-LRB-
cord-006860-a3b8hyyr	2156	35	ASN	ASN	NNP
cord-006860-a3b8hyyr	2156	36	activity	activity	NN
cord-006860-a3b8hyyr	2156	37	,	,	,
cord-006860-a3b8hyyr	2156	38	asparagine	asparagine	NN
cord-006860-a3b8hyyr	2156	39	depletion	depletion	NN
cord-006860-a3b8hyyr	2156	40	)	)	-RRB-
cord-006860-a3b8hyyr	2156	41	with	with	IN
cord-006860-a3b8hyyr	2156	42	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	2156	43	parameters	parameter	NNS
cord-006860-a3b8hyyr	2156	44	(	(	-LRB-
cord-006860-a3b8hyyr	2156	45	plasminogen	plasminogen	NNP
cord-006860-a3b8hyyr	2156	46	(	(	-LRB-
cord-006860-a3b8hyyr	2156	47	plas	plas	NNP
cord-006860-a3b8hyyr	2156	48	)	)	-RRB-
cord-006860-a3b8hyyr	2156	49	,	,	,
cord-006860-a3b8hyyr	2156	50	o.2-antiphismin	o.2-antiphismin	NNP
cord-006860-a3b8hyyr	2156	51	(	(	-LRB-
cord-006860-a3b8hyyr	2156	52	ct2AP	ct2AP	NNP
cord-006860-a3b8hyyr	2156	53	)	)	-RRB-
cord-006860-a3b8hyyr	2156	54	,	,	,
cord-006860-a3b8hyyr	2156	55	tissue	tissue	NN
cord-006860-a3b8hyyr	2156	56	-	-	HYPH
cord-006860-a3b8hyyr	2156	57	type	type	NN
cord-006860-a3b8hyyr	2156	58	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	2156	59	activator	activator	NN
cord-006860-a3b8hyyr	2156	60	(	(	-LRB-
cord-006860-a3b8hyyr	2156	61	t	t	NNP
cord-006860-a3b8hyyr	2156	62	-	-	HYPH
cord-006860-a3b8hyyr	2156	63	PA	PA	NNP
cord-006860-a3b8hyyr	2156	64	)	)	-RRB-
cord-006860-a3b8hyyr	2156	65	,	,	,
cord-006860-a3b8hyyr	2156	66	tissue	tissue	NN
cord-006860-a3b8hyyr	2156	67	type	type	NN
cord-006860-a3b8hyyr	2156	68	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	2156	69	activator	activator	NN
cord-006860-a3b8hyyr	2156	70	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2156	71	1	1	CD
cord-006860-a3b8hyyr	2156	72	(	(	-LRB-
cord-006860-a3b8hyyr	2156	73	PAl	PAl	NNP
cord-006860-a3b8hyyr	2156	74	1	1	CD
cord-006860-a3b8hyyr	2156	75	)	)	-RRB-
cord-006860-a3b8hyyr	2156	76	,	,	,
cord-006860-a3b8hyyr	2156	77	D	D	NNP
cord-006860-a3b8hyyr	2156	78	-I)imer	-i)imer	CD
cord-006860-a3b8hyyr	2156	79	(	(	-LRB-
cord-006860-a3b8hyyr	2156	80	I)-D	I)-D	NNP
cord-006860-a3b8hyyr	2156	81	)	)	-RRB-
cord-006860-a3b8hyyr	2156	82	)	)	-RRB-
cord-006860-a3b8hyyr	2156	83	.	.	.
cord-006860-a3b8hyyr	2157	1	Together	together	RB
cord-006860-a3b8hyyr	2157	2	with	with	IN
cord-006860-a3b8hyyr	2157	3	prednisono	prednisono	NNS
cord-006860-a3b8hyyr	2157	4	,	,	,
cord-006860-a3b8hyyr	2157	5	vincristine	vincristine	NN
cord-006860-a3b8hyyr	2157	6	and	and	CC
cord-006860-a3b8hyyr	2157	7	an	an	DT
cord-006860-a3b8hyyr	2157	8	anthracycline	anthracycline	JJ
cord-006860-a3b8hyyr	2157	9	20	20	CD
cord-006860-a3b8hyyr	2157	10	children	child	NNS
cord-006860-a3b8hyyr	2157	11	received	receive	VBD
cord-006860-a3b8hyyr	2157	12	I0000	I0000	NNP
cord-006860-a3b8hyyr	2157	13	IU-/m	IU-/m	NNS
cord-006860-a3b8hyyr	2157	14	2	2	CD
cord-006860-a3b8hyyr	2157	15	ASN	ASN	NNP
cord-006860-a3b8hyyr	2157	16	Medae	Medae	NNP
cord-006860-a3b8hyyr	2157	17	R	r	NN
cord-006860-a3b8hyyr	2157	18	(	(	-LRB-
cord-006860-a3b8hyyr	2157	19	originally	originally	RB
cord-006860-a3b8hyyr	2157	20	purchased	purchase	VBN
cord-006860-a3b8hyyr	2157	21	:	:	:
cord-006860-a3b8hyyr	2157	22	Kyowa	Kyowa	NNP
cord-006860-a3b8hyyr	2157	23	Hakko	Hakko	NNP
cord-006860-a3b8hyyr	2157	24	,	,	,
cord-006860-a3b8hyyr	2157	25	Kyogo	Kyogo	NNP
cord-006860-a3b8hyyr	2157	26	Japan	Japan	NNP
cord-006860-a3b8hyyr	2157	27	)	)	-RRB-
cord-006860-a3b8hyyr	2157	28	and	and	CC
cord-006860-a3b8hyyr	2157	29	20	20	CD
cord-006860-a3b8hyyr	2157	30	children	child	NNS
cord-006860-a3b8hyyr	2157	31	10000	10000	CD
cord-006860-a3b8hyyr	2157	32	IU	IU	NNP
cord-006860-a3b8hyyr	2157	33	/	/	SYM
cord-006860-a3b8hyyr	2157	34	m	m	NN
cord-006860-a3b8hyyr	2157	35	2	2	CD
cord-006860-a3b8hyyr	2157	36	Crasintin	Crasintin	NNP
cord-006860-a3b8hyyr	2157	37	R	R	NNP
cord-006860-a3b8hyyr	2157	38	(	(	-LRB-
cord-006860-a3b8hyyr	2157	39	Bayer	Bayer	NNP
cord-006860-a3b8hyyr	2157	40	,	,	,
cord-006860-a3b8hyyr	2157	41	Leverkusen	Leverkusen	NNP
cord-006860-a3b8hyyr	2157	42	,	,	,
cord-006860-a3b8hyyr	2157	43	Germany	Germany	NNP
cord-006860-a3b8hyyr	2157	44	)	)	-RRB-
cord-006860-a3b8hyyr	2157	45	.	.	.
cord-006860-a3b8hyyr	2158	1	Blood	blood	NN
cord-006860-a3b8hyyr	2158	2	samples	sample	NNS
cord-006860-a3b8hyyr	2158	3	for	for	IN
cord-006860-a3b8hyyr	2158	4	pharmacokinetic	pharmacokinetic	JJ
cord-006860-a3b8hyyr	2158	5	and	and	CC
cord-006860-a3b8hyyr	2158	6	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2158	7	analysis	analysis	NN
cord-006860-a3b8hyyr	2158	8	were	be	VBD
cord-006860-a3b8hyyr	2158	9	drawn	draw	VBN
cord-006860-a3b8hyyr	2158	10	before	before	IN
cord-006860-a3b8hyyr	2158	11	the	the	DT
cord-006860-a3b8hyyr	2158	12	first	first	JJ
cord-006860-a3b8hyyr	2158	13	ASN	ASN	NNP
cord-006860-a3b8hyyr	2158	14	administration	administration	NN
cord-006860-a3b8hyyr	2158	15	and	and	CC
cord-006860-a3b8hyyr	2158	16	every	every	DT
cord-006860-a3b8hyyr	2158	17	third	third	JJ
cord-006860-a3b8hyyr	2158	18	day	day	NN
cord-006860-a3b8hyyr	2158	19	whilst	whilst	IN
cord-006860-a3b8hyyr	2158	20	on	on	IN
cord-006860-a3b8hyyr	2158	21	medication	medication	NN
cord-006860-a3b8hyyr	2158	22	.	.	.
cord-006860-a3b8hyyr	2159	1	The	the	DT
cord-006860-a3b8hyyr	2159	2	results	result	NNS
cord-006860-a3b8hyyr	2159	3	are	be	VBP
cord-006860-a3b8hyyr	2159	4	shown	show	VBN
cord-006860-a3b8hyyr	2159	5	in	in	IN
cord-006860-a3b8hyyr	2159	6	the	the	DT
cord-006860-a3b8hyyr	2159	7	0.05	0.05	CD
cord-006860-a3b8hyyr	2159	8	ASN	asn	NN
cord-006860-a3b8hyyr	2159	9	activity	activity	NN
cord-006860-a3b8hyyr	2159	10	shows	show	VBZ
cord-006860-a3b8hyyr	2159	11	a	a	DT
cord-006860-a3b8hyyr	2159	12	negative	negative	JJ
cord-006860-a3b8hyyr	2159	13	correlation	correlation	NN
cord-006860-a3b8hyyr	2159	14	(	(	-LRB-
cord-006860-a3b8hyyr	2159	15	Spearman	spearman	NN
cord-006860-a3b8hyyr	2159	16	:	:	:
cord-006860-a3b8hyyr	2159	17	rho	rho	NN
cord-006860-a3b8hyyr	2159	18	/	/	SYM
cord-006860-a3b8hyyr	2159	19	p	p	NN
cord-006860-a3b8hyyr	2159	20	)	)	-RRB-
cord-006860-a3b8hyyr	2159	21	to	to	IN
cord-006860-a3b8hyyr	2159	22	plas	plas	NNP
cord-006860-a3b8hyyr	2159	23	(	(	-LRB-
cord-006860-a3b8hyyr	2159	24	-,637/0.0003	-,637/0.0003	NNP
cord-006860-a3b8hyyr	2159	25	)	)	-RRB-
cord-006860-a3b8hyyr	2159	26	and	and	CC
cord-006860-a3b8hyyr	2159	27	ct2AP	ct2AP	NNP
cord-006860-a3b8hyyr	2160	1	(	(	-LRB-
cord-006860-a3b8hyyr	2160	2	-	-	:
cord-006860-a3b8hyyr	2160	3	,	,	,
cord-006860-a3b8hyyr	2160	4	751/0.0001	751/0.0001	CD
cord-006860-a3b8hyyr	2160	5	)	)	-RRB-
cord-006860-a3b8hyyr	2160	6	.	.	.
cord-006860-a3b8hyyr	2161	1	A	a	DT
cord-006860-a3b8hyyr	2161	2	positive	positive	JJ
cord-006860-a3b8hyyr	2161	3	correlation	correlation	NN
cord-006860-a3b8hyyr	2161	4	was	be	VBD
cord-006860-a3b8hyyr	2161	5	found	find	VBN
cord-006860-a3b8hyyr	2161	6	between	between	IN
cord-006860-a3b8hyyr	2161	7	ASN	asn	NN
cord-006860-a3b8hyyr	2161	8	activity	activity	NN
cord-006860-a3b8hyyr	2161	9	and	and	CC
cord-006860-a3b8hyyr	2161	10	D	d	NN
cord-006860-a3b8hyyr	2161	11	-Dimer	-Dimer	NNP
cord-006860-a3b8hyyr	2161	12	formation	formation	NN
cord-006860-a3b8hyyr	2161	13	(	(	-LRB-
cord-006860-a3b8hyyr	2161	14	0.475/0.01	0.475/0.01	CD
cord-006860-a3b8hyyr	2161	15	)	)	-RRB-
cord-006860-a3b8hyyr	2161	16	.	.	.
cord-006860-a3b8hyyr	2162	1	T	T	NNP
cord-006860-a3b8hyyr	2162	2	-	-	HYPH
cord-006860-a3b8hyyr	2162	3	PA	PA	NNP
cord-006860-a3b8hyyr	2162	4	and	and	CC
cord-006860-a3b8hyyr	2162	5	PAl	PAl	NNS
cord-006860-a3b8hyyr	2162	6	1	1	CD
cord-006860-a3b8hyyr	2162	7	showed	show	VBD
cord-006860-a3b8hyyr	2162	8	no	no	DT
cord-006860-a3b8hyyr	2162	9	relationship	relationship	NN
cord-006860-a3b8hyyr	2162	10	to	to	IN
cord-006860-a3b8hyyr	2162	11	ASN	asn	NN
cord-006860-a3b8hyyr	2162	12	activity	activity	NN
cord-006860-a3b8hyyr	2162	13	.	.	.
cord-006860-a3b8hyyr	2163	1	All	all	DT
cord-006860-a3b8hyyr	2163	2	children	child	NNS
cord-006860-a3b8hyyr	2163	3	showed	show	VBD
cord-006860-a3b8hyyr	2163	4	complete	complete	JJ
cord-006860-a3b8hyyr	2163	5	aspamgiue	aspamgiue	JJ
cord-006860-a3b8hyyr	2163	6	depletion	depletion	NN
cord-006860-a3b8hyyr	2163	7	at	at	IN
cord-006860-a3b8hyyr	2163	8	a	a	DT
cord-006860-a3b8hyyr	2163	9	detection	detection	NN
cord-006860-a3b8hyyr	2163	10	limit	limit	NN
cord-006860-a3b8hyyr	2163	11	of	of	IN
cord-006860-a3b8hyyr	2163	12	0.1	0.1	CD
cord-006860-a3b8hyyr	2163	13	uM	um	UH
cord-006860-a3b8hyyr	2163	14	during	during	IN
cord-006860-a3b8hyyr	2163	15	the	the	DT
cord-006860-a3b8hyyr	2163	16	course	course	NN
cord-006860-a3b8hyyr	2163	17	of	of	IN
cord-006860-a3b8hyyr	2163	18	ASN	ASN	NNP
cord-006860-a3b8hyyr	2163	19	admiatstration	admiatstration	NN
cord-006860-a3b8hyyr	2163	20	.	.	.
cord-006860-a3b8hyyr	2164	1	Two	two	CD
cord-006860-a3b8hyyr	2164	2	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	2164	3	events	event	NNS
cord-006860-a3b8hyyr	2164	4	occurred	occur	VBD
cord-006860-a3b8hyyr	2164	5	in	in	IN
cord-006860-a3b8hyyr	2164	6	the	the	DT
cord-006860-a3b8hyyr	2164	7	Kyowa	Kyowa	NNP
cord-006860-a3b8hyyr	2164	8	group	group	NN
cord-006860-a3b8hyyr	2164	9	,	,	,
cord-006860-a3b8hyyr	2164	10	One	one	CD
cord-006860-a3b8hyyr	2164	11	of	of	IN
cord-006860-a3b8hyyr	2164	12	the	the	DT
cord-006860-a3b8hyyr	2164	13	distinctions	distinction	NNS
cord-006860-a3b8hyyr	2164	14	between	between	IN
cord-006860-a3b8hyyr	2164	15	the	the	DT
cord-006860-a3b8hyyr	2164	16	two	two	CD
cord-006860-a3b8hyyr	2164	17	E.	E.	NNP
cord-006860-a3b8hyyr	2164	18	coli	coli	NNS
cord-006860-a3b8hyyr	2164	19	ASN	asn	NN
cord-006860-a3b8hyyr	2164	20	preparations	preparation	NNS
cord-006860-a3b8hyyr	2164	21	administered	administer	VBD
cord-006860-a3b8hyyr	2164	22	ill	ill	RB
cord-006860-a3b8hyyr	2164	23	this	this	DT
cord-006860-a3b8hyyr	2164	24	stndy	stndy	NN
cord-006860-a3b8hyyr	2164	25	is	be	VBZ
cord-006860-a3b8hyyr	2164	26	the	the	DT
cord-006860-a3b8hyyr	2164	27	absence	absence	NN
cord-006860-a3b8hyyr	2164	28	of	of	IN
cord-006860-a3b8hyyr	2164	29	cystine	cystine	NN
cord-006860-a3b8hyyr	2164	30	in	in	IN
cord-006860-a3b8hyyr	2164	31	the	the	DT
cord-006860-a3b8hyyr	2164	32	Kyowa	Kyowa	NNP
cord-006860-a3b8hyyr	2164	33	ASN	ASN	NNP
cord-006860-a3b8hyyr	2164	34	,	,	,
cord-006860-a3b8hyyr	2164	35	which	which	WDT
cord-006860-a3b8hyyr	2164	36	also	also	RB
cord-006860-a3b8hyyr	2164	37	has	have	VBZ
cord-006860-a3b8hyyr	2164	38	a	a	DT
cord-006860-a3b8hyyr	2164	39	lower	lower	RBR
cord-006860-a3b8hyyr	2164	40	isoelectric	isoelectric	JJ
cord-006860-a3b8hyyr	2164	41	point	point	NN
cord-006860-a3b8hyyr	2164	42	and	and	CC
cord-006860-a3b8hyyr	2164	43	a	a	DT
cord-006860-a3b8hyyr	2164	44	longer	long	JJR
cord-006860-a3b8hyyr	2164	45	half	half	JJ
cord-006860-a3b8hyyr	2164	46	-	-	HYPH
cord-006860-a3b8hyyr	2164	47	life	life	NN
cord-006860-a3b8hyyr	2164	48	than	than	IN
cord-006860-a3b8hyyr	2164	49	the	the	DT
cord-006860-a3b8hyyr	2164	50	Bayer	Bayer	NNP
cord-006860-a3b8hyyr	2164	51	type	type	NN
cord-006860-a3b8hyyr	2164	52	A	a	DT
cord-006860-a3b8hyyr	2164	53	ASN	asn	NN
cord-006860-a3b8hyyr	2164	54	.	.	.
cord-006860-a3b8hyyr	2165	1	With	with	IN
cord-006860-a3b8hyyr	2165	2	respect	respect	NN
cord-006860-a3b8hyyr	2165	3	to	to	IN
cord-006860-a3b8hyyr	2165	4	this	this	DT
cord-006860-a3b8hyyr	2165	5	observations	observation	NNS
cord-006860-a3b8hyyr	2165	6	this	this	DT
cord-006860-a3b8hyyr	2165	7	may	may	MD
cord-006860-a3b8hyyr	2165	8	lead	lead	VB
cord-006860-a3b8hyyr	2165	9	to	to	IN
cord-006860-a3b8hyyr	2165	10	longer	long	JJR
cord-006860-a3b8hyyr	2165	11	inhibition	inhibition	NN
cord-006860-a3b8hyyr	2165	12	of	of	IN
cord-006860-a3b8hyyr	2165	13	protein	protein	NN
cord-006860-a3b8hyyr	2165	14	synthesis	synthesis	NN
cord-006860-a3b8hyyr	2165	15	,	,	,
cord-006860-a3b8hyyr	2165	16	which	which	WDT
cord-006860-a3b8hyyr	2165	17	then	then	RB
cord-006860-a3b8hyyr	2165	18	may	may	MD
cord-006860-a3b8hyyr	2165	19	be	be	VB
cord-006860-a3b8hyyr	2165	20	the	the	DT
cord-006860-a3b8hyyr	2165	21	cause	cause	NN
cord-006860-a3b8hyyr	2165	22	of	of	IN
cord-006860-a3b8hyyr	2165	23	a	a	DT
cord-006860-a3b8hyyr	2165	24	bigher	bigher	JJ
cord-006860-a3b8hyyr	2165	25	rate	rate	NN
cord-006860-a3b8hyyr	2165	26	of	of	IN
cord-006860-a3b8hyyr	2165	27	side	side	NN
cord-006860-a3b8hyyr	2165	28	effects	effect	NNS
cord-006860-a3b8hyyr	2165	29	.	.	.
cord-006860-a3b8hyyr	2166	1	Along	along	IN
cord-006860-a3b8hyyr	2166	2	with	with	IN
cord-006860-a3b8hyyr	2166	3	studies	study	NNS
cord-006860-a3b8hyyr	2166	4	on	on	IN
cord-006860-a3b8hyyr	2166	5	ASN	asn	NN
cord-006860-a3b8hyyr	2166	6	pharmacokinoties	pharmacokinotie	NNS
cord-006860-a3b8hyyr	2166	7	dose	dose	NN
cord-006860-a3b8hyyr	2166	8	recommendations	recommendation	NNS
cord-006860-a3b8hyyr	2166	9	need	need	VBP
cord-006860-a3b8hyyr	2166	10	to	to	TO
cord-006860-a3b8hyyr	2166	11	be	be	VB
cord-006860-a3b8hyyr	2166	12	tailored	tailor	VBN
cord-006860-a3b8hyyr	2166	13	to	to	IN
cord-006860-a3b8hyyr	2166	14	the	the	DT
cord-006860-a3b8hyyr	2166	15	specific	specific	JJ
cord-006860-a3b8hyyr	2166	16	ASN	asn	NN
cord-006860-a3b8hyyr	2166	17	preparation	preparation	NN
cord-006860-a3b8hyyr	2166	18	employed	employ	VBN
cord-006860-a3b8hyyr	2166	19	to	to	TO
cord-006860-a3b8hyyr	2166	20	ensure	ensure	VB
cord-006860-a3b8hyyr	2166	21	optimal	optimal	JJ
cord-006860-a3b8hyyr	2166	22	antineoplastic	antineoplastic	JJ
cord-006860-a3b8hyyr	2166	23	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2166	24	while	while	IN
cord-006860-a3b8hyyr	2166	25	minimizing	minimize	VBG
cord-006860-a3b8hyyr	2166	26	the	the	DT
cord-006860-a3b8hyyr	2166	27	hazard	hazard	NN
cord-006860-a3b8hyyr	2166	28	of	of	IN
cord-006860-a3b8hyyr	2166	29	complications	complication	NNS
cord-006860-a3b8hyyr	2166	30	.	.	.
cord-006860-a3b8hyyr	2167	1	DIFFERENT	different	JJ
cord-006860-a3b8hyyr	2167	2	TYPES	type	NNS
cord-006860-a3b8hyyr	2167	3	OF	of	IN
cord-006860-a3b8hyyr	2167	4	COAGULOPATHY	COAGULOPATHY	NNP
cord-006860-a3b8hyyr	2167	5	IN	in	IN
cord-006860-a3b8hyyr	2167	6	HEPATIC	HEPATIC	NNP
cord-006860-a3b8hyyr	2167	7	VENO	VENO	NNP
cord-006860-a3b8hyyr	2167	8	-	-	HYPH
cord-006860-a3b8hyyr	2167	9	OCCLUSIVE	OCCLUSIVE	NNP
cord-006860-a3b8hyyr	2167	10	DISEASE	DISEASE	NNP
cord-006860-a3b8hyyr	2167	11	(	(	-LRB-
cord-006860-a3b8hyyr	2167	12	VOD	VOD	NNP
cord-006860-a3b8hyyr	2167	13	)	)	-RRB-
cord-006860-a3b8hyyr	2167	14	AND	and	CC
cord-006860-a3b8hyyr	2167	15	CAPILLARY	capillary	JJ
cord-006860-a3b8hyyr	2167	16	LEAKAGE	leakage	NN
cord-006860-a3b8hyyr	2167	17	SYN	syn	NN
cord-006860-a3b8hyyr	2167	18	-	-	HYPH
cord-006860-a3b8hyyr	2167	19	DROME	DROME	NNP
cord-006860-a3b8hyyr	2167	20	(	(	-LRB-
cord-006860-a3b8hyyr	2167	21	CLS	CLS	NNP
cord-006860-a3b8hyyr	2167	22	)	)	-RRB-
cord-006860-a3b8hyyr	2167	23	AFTER	after	IN
cord-006860-a3b8hyyr	2167	24	BONE	bone	NN
cord-006860-a3b8hyyr	2167	25	MARROW	marrow	NN
cord-006860-a3b8hyyr	2167	26	TRANSPLANTATION	TRANSPLANTATION	VBZ
cord-006860-a3b8hyyr	2167	27	W.	W.	NNP
cord-006860-a3b8hyyr	2167	28	Ntimberger	Ntimberger	NNP
cord-006860-a3b8hyyr	2167	29	,	,	,
cord-006860-a3b8hyyr	2167	30	S.	S.	NNP
cord-006860-a3b8hyyr	2167	31	Eckhof	Eckhof	NNP
cord-006860-a3b8hyyr	2167	32	-	-	HYPH
cord-006860-a3b8hyyr	2167	33	Donovan	Donovan	NNP
cord-006860-a3b8hyyr	2167	34	,	,	,
cord-006860-a3b8hyyr	2167	35	St.	St.	NNP
cord-006860-a3b8hyyr	2167	36	Burdaeh	Burdaeh	NNP
cord-006860-a3b8hyyr	2167	37	and	and	CC
cord-006860-a3b8hyyr	2167	38	U.	U.	NNP
cord-006860-a3b8hyyr	2167	39	G6bel	G6bel	NNP
cord-006860-a3b8hyyr	2167	40	Department	Department	NNP
cord-006860-a3b8hyyr	2167	41	for	for	IN
cord-006860-a3b8hyyr	2167	42	Pediatric	Pediatric	NNP
cord-006860-a3b8hyyr	2167	43	Hematology	Hematology	NNP
cord-006860-a3b8hyyr	2167	44	and	and	CC
cord-006860-a3b8hyyr	2167	45	Oncology	Oncology	NNP
cord-006860-a3b8hyyr	2167	46	,	,	,
cord-006860-a3b8hyyr	2167	47	Heinrich	Heinrich	NNP
cord-006860-a3b8hyyr	2167	48	Heine	Heine	NNP
cord-006860-a3b8hyyr	2167	49	University	University	NNP
cord-006860-a3b8hyyr	2167	50	Medical	Medical	NNP
cord-006860-a3b8hyyr	2167	51	Center	Center	NNP
cord-006860-a3b8hyyr	2167	52	,	,	,
cord-006860-a3b8hyyr	2167	53	Diisseldoff	Diisseldoff	NNP
cord-006860-a3b8hyyr	2167	54	,	,	,
cord-006860-a3b8hyyr	2167	55	Germany	Germany	NNP
cord-006860-a3b8hyyr	2168	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	2168	2	is	be	VBZ
cord-006860-a3b8hyyr	2168	3	generally	generally	RB
cord-006860-a3b8hyyr	2168	4	accepted	accept	VBN
cord-006860-a3b8hyyr	2168	5	,	,	,
cord-006860-a3b8hyyr	2168	6	that	that	IN
cord-006860-a3b8hyyr	2168	7	CLS	CLS	NNP
cord-006860-a3b8hyyr	2168	8	,	,	,
cord-006860-a3b8hyyr	2168	9	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2168	10	activation	activation	NN
cord-006860-a3b8hyyr	2168	11	and	and	CC
cord-006860-a3b8hyyr	2168	12	refractoriness	refractoriness	NN
cord-006860-a3b8hyyr	2168	13	to	to	IN
cord-006860-a3b8hyyr	2168	14	platelet	platelet	NN
cord-006860-a3b8hyyr	2168	15	transfusions	transfusion	NNS
cord-006860-a3b8hyyr	2168	16	are	be	VBP
cord-006860-a3b8hyyr	2168	17	part	part	NN
cord-006860-a3b8hyyr	2168	18	of	of	IN
cord-006860-a3b8hyyr	2168	19	the	the	DT
cord-006860-a3b8hyyr	2168	20	syndrome	syndrome	NN
cord-006860-a3b8hyyr	2168	21	of	of	IN
cord-006860-a3b8hyyr	2168	22	hepatic	hepatic	JJ
cord-006860-a3b8hyyr	2168	23	VOD	vod	NN
cord-006860-a3b8hyyr	2168	24	.	.	.
cord-006860-a3b8hyyr	2169	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2169	2	assessed	assess	VBD
cord-006860-a3b8hyyr	2169	3	patients	patient	NNS
cord-006860-a3b8hyyr	2169	4	with	with	IN
cord-006860-a3b8hyyr	2169	5	either	either	CC
cord-006860-a3b8hyyr	2169	6	VOD	VOD	NNP
cord-006860-a3b8hyyr	2169	7	or	or	CC
cord-006860-a3b8hyyr	2169	8	CLS	CLS	NNP
cord-006860-a3b8hyyr	2169	9	or	or	CC
cord-006860-a3b8hyyr	2169	10	both	both	CC
cord-006860-a3b8hyyr	2169	11	VOD	VOD	NNP
cord-006860-a3b8hyyr	2169	12	and	and	CC
cord-006860-a3b8hyyr	2169	13	CLS	CLS	NNP
cord-006860-a3b8hyyr	2169	14	,	,	,
cord-006860-a3b8hyyr	2169	15	in	in	IN
cord-006860-a3b8hyyr	2169	16	order	order	NN
cord-006860-a3b8hyyr	2169	17	to	to	TO
cord-006860-a3b8hyyr	2169	18	analyze	analyze	VB
cord-006860-a3b8hyyr	2169	19	the	the	DT
cord-006860-a3b8hyyr	2169	20	influence	influence	NN
cord-006860-a3b8hyyr	2169	21	of	of	IN
cord-006860-a3b8hyyr	2169	22	either	either	DT
cord-006860-a3b8hyyr	2169	23	syndrome	syndrome	NN
cord-006860-a3b8hyyr	2169	24	on	on	IN
cord-006860-a3b8hyyr	2169	25	different	different	JJ
cord-006860-a3b8hyyr	2169	26	aspects	aspect	NNS
cord-006860-a3b8hyyr	2169	27	of	of	IN
cord-006860-a3b8hyyr	2169	28	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	2169	29	.	.	.
cord-006860-a3b8hyyr	2170	1	VOD	VOD	NNP
cord-006860-a3b8hyyr	2170	2	was	be	VBD
cord-006860-a3b8hyyr	2170	3	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	2170	4	according	accord	VBG
cord-006860-a3b8hyyr	2170	5	to	to	IN
cord-006860-a3b8hyyr	2170	6	Jones	Jones	NNP
cord-006860-a3b8hyyr	2170	7	et	et	NNP
cord-006860-a3b8hyyr	2170	8	al	al	NNP
cord-006860-a3b8hyyr	2170	9	.	.	.
cord-006860-a3b8hyyr	2171	1	[	[	-LRB-
cord-006860-a3b8hyyr	2171	2	Transplantation	transplantation	NN
cord-006860-a3b8hyyr	2171	3	44	44	CD
cord-006860-a3b8hyyr	2171	4	(	(	-LRB-
cord-006860-a3b8hyyr	2171	5	1987	1987	CD
cord-006860-a3b8hyyr	2171	6	)	)	-RRB-
cord-006860-a3b8hyyr	2171	7	778	778	CD
cord-006860-a3b8hyyr	2171	8	]	]	-RRB-
cord-006860-a3b8hyyr	2171	9	.	.	.
cord-006860-a3b8hyyr	2172	1	Diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	2172	2	of	of	IN
cord-006860-a3b8hyyr	2172	3	CLS	CLS	NNP
cord-006860-a3b8hyyr	2172	4	was	be	VBD
cord-006860-a3b8hyyr	2172	5	>	>	XX
cord-006860-a3b8hyyr	2172	6	_	_	NN
cord-006860-a3b8hyyr	2172	7	3	3	CD
cord-006860-a3b8hyyr	2172	8	%	%	NN
cord-006860-a3b8hyyr	2172	9	increase	increase	NN
cord-006860-a3b8hyyr	2172	10	of	of	IN
cord-006860-a3b8hyyr	2172	11	body	body	NN
cord-006860-a3b8hyyr	2172	12	weight	weight	NN
cord-006860-a3b8hyyr	2172	13	in	in	IN
cord-006860-a3b8hyyr	2172	14	the	the	DT
cord-006860-a3b8hyyr	2172	15	past	past	JJ
cord-006860-a3b8hyyr	2172	16	24	24	CD
cord-006860-a3b8hyyr	2172	17	hours	hour	NNS
cord-006860-a3b8hyyr	2172	18	and	and	CC
cord-006860-a3b8hyyr	2172	19	non	non	JJ
cord-006860-a3b8hyyr	2172	20	-	-	JJ
cord-006860-a3b8hyyr	2172	21	responsiveness	responsiveness	NN
cord-006860-a3b8hyyr	2172	22	to	to	IN
cord-006860-a3b8hyyr	2172	23	furosemide	furosemide	NN
cord-006860-a3b8hyyr	2173	1	[	[	-LRB-
cord-006860-a3b8hyyr	2173	2	Niirnberger	Niirnberger	NNP
cord-006860-a3b8hyyr	2173	3	et	et	NNP
cord-006860-a3b8hyyr	2173	4	al	al	NNP
cord-006860-a3b8hyyr	2173	5	.	.	.
cord-006860-a3b8hyyr	2174	1	,	,	,
cord-006860-a3b8hyyr	2174	2	Ann	Ann	NNP
cord-006860-a3b8hyyr	2174	3	Hematol	Hematol	NNP
cord-006860-a3b8hyyr	2174	4	17	17	CD
cord-006860-a3b8hyyr	2174	5	(	(	-LRB-
cord-006860-a3b8hyyr	2174	6	1993	1993	CD
cord-006860-a3b8hyyr	2174	7	)	)	-RRB-
cord-006860-a3b8hyyr	2174	8	67	67	CD
cord-006860-a3b8hyyr	2174	9	]	]	-RRB-
cord-006860-a3b8hyyr	2174	10	.	.	.
cord-006860-a3b8hyyr	2175	1	Patients	patient	NNS
cord-006860-a3b8hyyr	2175	2	with	with	IN
cord-006860-a3b8hyyr	2175	3	VOD	VOD	NNP
cord-006860-a3b8hyyr	2175	4	,	,	,
cord-006860-a3b8hyyr	2175	5	CLS	CLS	NNP
cord-006860-a3b8hyyr	2175	6	or	or	CC
cord-006860-a3b8hyyr	2175	7	both	both	DT
cord-006860-a3b8hyyr	2175	8	were	be	VBD
cord-006860-a3b8hyyr	2175	9	compared	compare	VBN
cord-006860-a3b8hyyr	2175	10	to	to	TO
cord-006860-a3b8hyyr	2175	11	control	control	VB
cord-006860-a3b8hyyr	2175	12	patients	patient	NNS
cord-006860-a3b8hyyr	2175	13	without	without	IN
cord-006860-a3b8hyyr	2175	14	either	either	DT
cord-006860-a3b8hyyr	2175	15	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	2175	16	.	.	.
cord-006860-a3b8hyyr	2176	1	Eight	eight	CD
cord-006860-a3b8hyyr	2176	2	patients	patient	NNS
cord-006860-a3b8hyyr	2176	3	suffered	suffer	VBD
cord-006860-a3b8hyyr	2176	4	from	from	IN
cord-006860-a3b8hyyr	2176	5	both	both	CC
cord-006860-a3b8hyyr	2176	6	VOD	VOD	NNP
cord-006860-a3b8hyyr	2176	7	and	and	CC
cord-006860-a3b8hyyr	2176	8	CLS	CLS	NNP
cord-006860-a3b8hyyr	2176	9	,	,	,
cord-006860-a3b8hyyr	2176	10	5	5	CD
cord-006860-a3b8hyyr	2176	11	patients	patient	NNS
cord-006860-a3b8hyyr	2176	12	only	only	RB
cord-006860-a3b8hyyr	2176	13	from	from	IN
cord-006860-a3b8hyyr	2176	14	VOD	VOD	NNP
cord-006860-a3b8hyyr	2176	15	,	,	,
cord-006860-a3b8hyyr	2176	16	and	and	CC
cord-006860-a3b8hyyr	2176	17	8	8	CD
cord-006860-a3b8hyyr	2176	18	only	only	RB
cord-006860-a3b8hyyr	2176	19	from	from	IN
cord-006860-a3b8hyyr	2176	20	CLS	CLS	NNP
cord-006860-a3b8hyyr	2176	21	.	.	.
cord-006860-a3b8hyyr	2177	1	61	61	CD
cord-006860-a3b8hyyr	2177	2	patients	patient	NNS
cord-006860-a3b8hyyr	2177	3	had	have	VBD
cord-006860-a3b8hyyr	2177	4	neither	neither	DT
cord-006860-a3b8hyyr	2177	5	syndrome	syndrome	NN
cord-006860-a3b8hyyr	2177	6	and	and	CC
cord-006860-a3b8hyyr	2177	7	served	serve	VBD
cord-006860-a3b8hyyr	2177	8	as	as	IN
cord-006860-a3b8hyyr	2177	9	control	control	NN
cord-006860-a3b8hyyr	2177	10	population	population	NN
cord-006860-a3b8hyyr	2177	11	.	.	.
cord-006860-a3b8hyyr	2178	1	Activation	activation	NN
cord-006860-a3b8hyyr	2178	2	of	of	IN
cord-006860-a3b8hyyr	2178	3	the	the	DT
cord-006860-a3b8hyyr	2178	4	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2178	5	system	system	NN
cord-006860-a3b8hyyr	2178	6	was	be	VBD
cord-006860-a3b8hyyr	2178	7	assessed	assess	VBN
cord-006860-a3b8hyyr	2178	8	by	by	IN
cord-006860-a3b8hyyr	2178	9	increase	increase	NN
cord-006860-a3b8hyyr	2178	10	of	of	IN
cord-006860-a3b8hyyr	2178	11	TAT	tat	NN
cord-006860-a3b8hyyr	2178	12	-	-	HYPH
cord-006860-a3b8hyyr	2178	13	complexes	complex	NNS
cord-006860-a3b8hyyr	2178	14	and/or	and/or	CC
cord-006860-a3b8hyyr	2178	15	increased	increased	JJ
cord-006860-a3b8hyyr	2178	16	consumption	consumption	NN
cord-006860-a3b8hyyr	2178	17	of	of	IN
cord-006860-a3b8hyyr	2178	18	AT	AT	NNP
cord-006860-a3b8hyyr	2178	19	IIL	IIL	NNP
cord-006860-a3b8hyyr	2179	1	The	the	DT
cord-006860-a3b8hyyr	2179	2	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	2179	3	patterns	pattern	NNS
cord-006860-a3b8hyyr	2179	4	were	be	VBD
cord-006860-a3b8hyyr	2179	5	as	as	IN
cord-006860-a3b8hyyr	2179	6	follows	follow	VBZ
cord-006860-a3b8hyyr	2179	7	:	:	:
cord-006860-a3b8hyyr	2180	1	No	no	UH
cord-006860-a3b8hyyr	2180	2	.	.	.
cord-006860-a3b8hyyr	2181	1	Introduction	introduction	NN
cord-006860-a3b8hyyr	2181	2	:	:	:
cord-006860-a3b8hyyr	2182	1	Lung	lung	NN
cord-006860-a3b8hyyr	2182	2	cancer	cancer	NN
cord-006860-a3b8hyyr	2182	3	goes	go	VBZ
cord-006860-a3b8hyyr	2182	4	along	along	RB
cord-006860-a3b8hyyr	2182	5	with	with	IN
cord-006860-a3b8hyyr	2182	6	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2182	7	activation	activation	NN
cord-006860-a3b8hyyr	2182	8	and	and	CC
cord-006860-a3b8hyyr	2182	9	increased	increase	VBN
cord-006860-a3b8hyyr	2182	10	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	2182	11	risk	risk	NN
cord-006860-a3b8hyyr	2182	12	.	.	.
cord-006860-a3b8hyyr	2183	1	Acute	acute	JJ
cord-006860-a3b8hyyr	2183	2	phase	phase	NN
cord-006860-a3b8hyyr	2183	3	reaction	reaction	NN
cord-006860-a3b8hyyr	2183	4	in	in	IN
cord-006860-a3b8hyyr	2183	5	cancer	cancer	NN
cord-006860-a3b8hyyr	2183	6	patients	patient	NNS
cord-006860-a3b8hyyr	2183	7	leads	lead	VBZ
cord-006860-a3b8hyyr	2183	8	to	to	IN
cord-006860-a3b8hyyr	2183	9	elevated	elevated	JJ
cord-006860-a3b8hyyr	2183	10	levels	level	NNS
cord-006860-a3b8hyyr	2183	11	of	of	IN
cord-006860-a3b8hyyr	2183	12	C4b	c4b	NN
cord-006860-a3b8hyyr	2183	13	-	-	HYPH
cord-006860-a3b8hyyr	2183	14	binding	bind	VBG
cord-006860-a3b8hyyr	2183	15	protein	protein	NN
cord-006860-a3b8hyyr	2183	16	(	(	-LRB-
cord-006860-a3b8hyyr	2183	17	C4b	C4b	NNP
cord-006860-a3b8hyyr	2183	18	-	-	HYPH
cord-006860-a3b8hyyr	2183	19	BP	BP	NNP
cord-006860-a3b8hyyr	2183	20	)	)	-RRB-
cord-006860-a3b8hyyr	2183	21	followed	follow	VBD
cord-006860-a3b8hyyr	2183	22	by	by	IN
cord-006860-a3b8hyyr	2183	23	a	a	DT
cord-006860-a3b8hyyr	2183	24	shift	shift	NN
cord-006860-a3b8hyyr	2183	25	from	from	IN
cord-006860-a3b8hyyr	2183	26	free	free	JJ
cord-006860-a3b8hyyr	2183	27	to	to	IN
cord-006860-a3b8hyyr	2183	28	C4b	c4b	NN
cord-006860-a3b8hyyr	2183	29	-	-	HYPH
cord-006860-a3b8hyyr	2183	30	BP	BP	NNP
cord-006860-a3b8hyyr	2183	31	-	-	HYPH
cord-006860-a3b8hyyr	2183	32	bound	bind	VBN
cord-006860-a3b8hyyr	2183	33	protein	protein	NN
cord-006860-a3b8hyyr	2183	34	S.	S.	NNP
cord-006860-a3b8hyyr	2184	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2184	2	tried	try	VBD
cord-006860-a3b8hyyr	2184	3	to	to	TO
cord-006860-a3b8hyyr	2184	4	find	find	VB
cord-006860-a3b8hyyr	2184	5	out	out	RP
cord-006860-a3b8hyyr	2184	6	whether	whether	IN
cord-006860-a3b8hyyr	2184	7	there	there	EX
cord-006860-a3b8hyyr	2184	8	is	be	VBZ
cord-006860-a3b8hyyr	2184	9	a	a	DT
cord-006860-a3b8hyyr	2184	10	correlation	correlation	NN
cord-006860-a3b8hyyr	2184	11	between	between	IN
cord-006860-a3b8hyyr	2184	12	alterations	alteration	NNS
cord-006860-a3b8hyyr	2184	13	of	of	IN
cord-006860-a3b8hyyr	2184	14	C4b	c4b	NN
cord-006860-a3b8hyyr	2184	15	-	-	HYPH
cord-006860-a3b8hyyr	2184	16	BP	BP	NNP
cord-006860-a3b8hyyr	2184	17	,	,	,
cord-006860-a3b8hyyr	2184	18	protein	protein	NN
cord-006860-a3b8hyyr	2184	19	C	c	NN
cord-006860-a3b8hyyr	2184	20	protein	protein	NN
cord-006860-a3b8hyyr	2184	21	S	S	NNP
cord-006860-a3b8hyyr	2184	22	system	system	NN
cord-006860-a3b8hyyr	2184	23	and	and	CC
cord-006860-a3b8hyyr	2184	24	interleukin	interleukin	NN
cord-006860-a3b8hyyr	2184	25	6	6	CD
cord-006860-a3b8hyyr	2184	26	(	(	-LRB-
cord-006860-a3b8hyyr	2184	27	IL-6	IL-6	NNP
cord-006860-a3b8hyyr	2184	28	)	)	-RRB-
cord-006860-a3b8hyyr	2184	29	,	,	,
cord-006860-a3b8hyyr	2184	30	which	which	WDT
cord-006860-a3b8hyyr	2184	31	is	be	VBZ
cord-006860-a3b8hyyr	2184	32	one	one	CD
cord-006860-a3b8hyyr	2184	33	of	of	IN
cord-006860-a3b8hyyr	2184	34	the	the	DT
cord-006860-a3b8hyyr	2184	35	most	most	RBS
cord-006860-a3b8hyyr	2184	36	potent	potent	JJ
cord-006860-a3b8hyyr	2184	37	inducers	inducer	NNS
cord-006860-a3b8hyyr	2184	38	of	of	IN
cord-006860-a3b8hyyr	2184	39	hepatic	hepatic	JJ
cord-006860-a3b8hyyr	2184	40	acute	acute	JJ
cord-006860-a3b8hyyr	2184	41	phase	phase	NN
cord-006860-a3b8hyyr	2184	42	reaction	reaction	NN
cord-006860-a3b8hyyr	2184	43	.	.	.
cord-006860-a3b8hyyr	2185	1	Patients	patient	NNS
cord-006860-a3b8hyyr	2185	2	:	:	:
cord-006860-a3b8hyyr	2186	1	I.	I.	NNP
cord-006860-a3b8hyyr	2186	2	25	25	CD
cord-006860-a3b8hyyr	2186	3	patients	patient	NNS
cord-006860-a3b8hyyr	2186	4	with	with	IN
cord-006860-a3b8hyyr	2186	5	lung	lung	NN
cord-006860-a3b8hyyr	2186	6	cancer	cancer	NN
cord-006860-a3b8hyyr	2186	7	;	;	:
cord-006860-a3b8hyyr	2186	8	2	2	CD
cord-006860-a3b8hyyr	2186	9	.	.	.
cord-006860-a3b8hyyr	2187	1	Control	Control	NNP
cord-006860-a3b8hyyr	2187	2	group	group	NN
cord-006860-a3b8hyyr	2187	3	:	:	:
cord-006860-a3b8hyyr	2187	4	11	11	CD
cord-006860-a3b8hyyr	2187	5	patients	patient	NNS
cord-006860-a3b8hyyr	2187	6	in	in	IN
cord-006860-a3b8hyyr	2187	7	complete	complete	JJ
cord-006860-a3b8hyyr	2187	8	remission	remission	NN
cord-006860-a3b8hyyr	2187	9	after	after	IN
cord-006860-a3b8hyyr	2187	10	lung	lung	NN
cord-006860-a3b8hyyr	2187	11	cancer	cancer	NN
cord-006860-a3b8hyyr	2187	12	.	.	.
cord-006860-a3b8hyyr	2188	1	Methods	method	NNS
cord-006860-a3b8hyyr	2188	2	:	:	:
cord-006860-a3b8hyyr	2189	1	Clotting	clotting	NN
cord-006860-a3b8hyyr	2189	2	methods	method	NNS
cord-006860-a3b8hyyr	2189	3	:	:	:
cord-006860-a3b8hyyr	2189	4	protein	protein	NN
cord-006860-a3b8hyyr	2189	5	C	C	NNP
cord-006860-a3b8hyyr	2189	6	and	and	CC
cord-006860-a3b8hyyr	2189	7	S	S	NNP
cord-006860-a3b8hyyr	2189	8	activity	activity	NN
cord-006860-a3b8hyyr	2190	1	;	;	:
cord-006860-a3b8hyyr	2190	2	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	2190	3	tests	test	VBZ
cord-006860-a3b8hyyr	2190	4	:	:	:
cord-006860-a3b8hyyr	2191	1	protein	protein	NNP
cord-006860-a3b8hyyr	2191	2	C	C	NNP
cord-006860-a3b8hyyr	2191	3	antigen	antigen	NN
cord-006860-a3b8hyyr	2191	4	,	,	,
cord-006860-a3b8hyyr	2191	5	TAT	tat	NN
cord-006860-a3b8hyyr	2191	6	-	-	HYPH
cord-006860-a3b8hyyr	2191	7	complexes	complex	NNS
cord-006860-a3b8hyyr	2191	8	,	,	,
cord-006860-a3b8hyyr	2191	9	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	2191	10	fragments	fragment	NNS
cord-006860-a3b8hyyr	2191	11	F	F	NNP
cord-006860-a3b8hyyr	2191	12	I+2	I+2	NNP
cord-006860-a3b8hyyr	2191	13	,	,	,
cord-006860-a3b8hyyr	2191	14	IL-6	IL-6	NNP
cord-006860-a3b8hyyr	2191	15	.	.	.
cord-006860-a3b8hyyr	2192	1	Electroimmuno	Electroimmuno	NNP
cord-006860-a3b8hyyr	2192	2	-	-	HYPH
cord-006860-a3b8hyyr	2192	3	diffusion	diffusion	NN
cord-006860-a3b8hyyr	2192	4	(	(	-LRB-
cord-006860-a3b8hyyr	2192	5	Laurell	Laurell	NNP
cord-006860-a3b8hyyr	2192	6	)	)	-RRB-
cord-006860-a3b8hyyr	2192	7	:	:	:
cord-006860-a3b8hyyr	2192	8	free	free	JJ
cord-006860-a3b8hyyr	2192	9	and	and	CC
cord-006860-a3b8hyyr	2192	10	total	total	JJ
cord-006860-a3b8hyyr	2192	11	protein	protein	NN
cord-006860-a3b8hyyr	2192	12	S	s	NN
cord-006860-a3b8hyyr	2192	13	,	,	,
cord-006860-a3b8hyyr	2192	14	C4b	C4b	NNP
cord-006860-a3b8hyyr	2192	15	-	-	HYPH
cord-006860-a3b8hyyr	2192	16	BP	BP	NNP
cord-006860-a3b8hyyr	2192	17	.	.	.
cord-006860-a3b8hyyr	2193	1	Results	result	NNS
cord-006860-a3b8hyyr	2193	2	:	:	:
cord-006860-a3b8hyyr	2194	1	TAT	tat	NN
cord-006860-a3b8hyyr	2194	2	-	-	HYPH
cord-006860-a3b8hyyr	2194	3	complexes	complex	NNS
cord-006860-a3b8hyyr	2194	4	and	and	CC
cord-006860-a3b8hyyr	2194	5	F	F	NNP
cord-006860-a3b8hyyr	2194	6	I+2	I+2	NNP
cord-006860-a3b8hyyr	2194	7	were	be	VBD
cord-006860-a3b8hyyr	2194	8	elevated	elevate	VBN
cord-006860-a3b8hyyr	2194	9	in	in	IN
cord-006860-a3b8hyyr	2194	10	cancer	cancer	NN
cord-006860-a3b8hyyr	2194	11	patients	patient	NNS
cord-006860-a3b8hyyr	2194	12	.	.	.
cord-006860-a3b8hyyr	2195	1	C4b	c4b	NN
cord-006860-a3b8hyyr	2195	2	-	-	HYPH
cord-006860-a3b8hyyr	2195	3	BP	BP	NNP
cord-006860-a3b8hyyr	2195	4	levels	level	NNS
cord-006860-a3b8hyyr	2195	5	were	be	VBD
cord-006860-a3b8hyyr	2195	6	slighthly	slighthly	RB
cord-006860-a3b8hyyr	2195	7	increased	increase	VBN
cord-006860-a3b8hyyr	2195	8	(	(	-LRB-
cord-006860-a3b8hyyr	2195	9	129±19	129±19	CD
cord-006860-a3b8hyyr	2195	10	%	%	NN
cord-006860-a3b8hyyr	2195	11	of	of	IN
cord-006860-a3b8hyyr	2195	12	n.	n.	NN
cord-006860-a3b8hyyr	2195	13	)	)	-RRB-
cord-006860-a3b8hyyr	2195	14	,	,	,
cord-006860-a3b8hyyr	2195	15	protein	protein	NN
cord-006860-a3b8hyyr	2195	16	S	S	NNP
cord-006860-a3b8hyyr	2195	17	activity	activity	NN
cord-006860-a3b8hyyr	2195	18	was	be	VBD
cord-006860-a3b8hyyr	2195	19	89±33	89±33	CD
cord-006860-a3b8hyyr	2195	20	%	%	NN
cord-006860-a3b8hyyr	2195	21	of	of	IN
cord-006860-a3b8hyyr	2195	22	n.	n.	NN
cord-006860-a3b8hyyr	2195	23	(	(	-LRB-
cord-006860-a3b8hyyr	2195	24	control	control	NNP
cord-006860-a3b8hyyr	2195	25	group	group	NN
cord-006860-a3b8hyyr	2195	26	:	:	:
cord-006860-a3b8hyyr	2195	27	108±23	108±23	CD
cord-006860-a3b8hyyr	2195	28	%	%	NN
cord-006860-a3b8hyyr	2195	29	of	of	IN
cord-006860-a3b8hyyr	2195	30	n.	n.	NN
cord-006860-a3b8hyyr	2195	31	)	)	-RRB-
cord-006860-a3b8hyyr	2195	32	.	.	.
cord-006860-a3b8hyyr	2196	1	IL-6	IL-6	NNP
cord-006860-a3b8hyyr	2196	2	in	in	IN
cord-006860-a3b8hyyr	2196	3	lung	lung	NN
cord-006860-a3b8hyyr	2196	4	cancer	cancer	NN
cord-006860-a3b8hyyr	2196	5	patients	patient	NNS
cord-006860-a3b8hyyr	2196	6	was	be	VBD
cord-006860-a3b8hyyr	2197	1	37.2252.9	37.2252.9	NNP
cord-006860-a3b8hyyr	2197	2	pg	pg	NNP
cord-006860-a3b8hyyr	2197	3	/	/	SYM
cord-006860-a3b8hyyr	2197	4	l	l	NNP
cord-006860-a3b8hyyr	2197	5	(	(	-LRB-
cord-006860-a3b8hyyr	2197	6	control	control	NN
cord-006860-a3b8hyyr	2197	7	:	:	:
cord-006860-a3b8hyyr	2197	8	27.2±8.2	27.2±8.2	CD
cord-006860-a3b8hyyr	2197	9	pg	pg	NNP
cord-006860-a3b8hyyr	2197	10	/	/	SYM
cord-006860-a3b8hyyr	2197	11	l	l	NN
cord-006860-a3b8hyyr	2197	12	)	)	-RRB-
cord-006860-a3b8hyyr	2197	13	.	.	.
cord-006860-a3b8hyyr	2198	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	2198	2	:	:	:
cord-006860-a3b8hyyr	2199	1	One	one	CD
cord-006860-a3b8hyyr	2199	2	source	source	NN
cord-006860-a3b8hyyr	2199	3	of	of	IN
cord-006860-a3b8hyyr	2199	4	the	the	DT
cord-006860-a3b8hyyr	2199	5	hypercoagulable	hypercoagulable	JJ
cord-006860-a3b8hyyr	2199	6	state	state	NN
cord-006860-a3b8hyyr	2199	7	in	in	IN
cord-006860-a3b8hyyr	2199	8	lung	lung	NN
cord-006860-a3b8hyyr	2199	9	cancer	cancer	NN
cord-006860-a3b8hyyr	2199	10	patients	patient	NNS
cord-006860-a3b8hyyr	2199	11	is	be	VBZ
cord-006860-a3b8hyyr	2199	12	decreased	decrease	VBN
cord-006860-a3b8hyyr	2199	13	protein	protein	NN
cord-006860-a3b8hyyr	2199	14	S	s	NN
cord-006860-a3b8hyyr	2199	15	activity	activity	NN
cord-006860-a3b8hyyr	2199	16	due	due	JJ
cord-006860-a3b8hyyr	2199	17	to	to	IN
cord-006860-a3b8hyyr	2199	18	elevated	elevated	JJ
cord-006860-a3b8hyyr	2199	19	C4b	c4b	NN
cord-006860-a3b8hyyr	2199	20	-	-	HYPH
cord-006860-a3b8hyyr	2199	21	BP	BP	NNP
cord-006860-a3b8hyyr	2199	22	levels	level	NNS
cord-006860-a3b8hyyr	2199	23	.	.	.
cord-006860-a3b8hyyr	2200	1	This	this	DT
cord-006860-a3b8hyyr	2200	2	is	be	VBZ
cord-006860-a3b8hyyr	2200	3	probably	probably	RB
cord-006860-a3b8hyyr	2200	4	caused	cause	VBN
cord-006860-a3b8hyyr	2200	5	by	by	IN
cord-006860-a3b8hyyr	2200	6	hepatic	hepatic	JJ
cord-006860-a3b8hyyr	2200	7	acute	acute	JJ
cord-006860-a3b8hyyr	2200	8	phase	phase	NN
cord-006860-a3b8hyyr	2200	9	reaction	reaction	NN
cord-006860-a3b8hyyr	2200	10	which	which	WDT
cord-006860-a3b8hyyr	2200	11	is	be	VBZ
cord-006860-a3b8hyyr	2200	12	triggered	trigger	VBN
cord-006860-a3b8hyyr	2200	13	by	by	IN
cord-006860-a3b8hyyr	2200	14	increased	increase	VBN
cord-006860-a3b8hyyr	2200	15	IL-6	IL-6	NNP
cord-006860-a3b8hyyr	2200	16	levels	level	NNS
cord-006860-a3b8hyyr	2200	17	.	.	.
cord-006860-a3b8hyyr	2201	1	These	these	DT
cord-006860-a3b8hyyr	2201	2	plasma	plasma	NN
cord-006860-a3b8hyyr	2201	3	levels	level	NNS
cord-006860-a3b8hyyr	2201	4	correlate	correlate	VBP
cord-006860-a3b8hyyr	2201	5	with	with	IN
cord-006860-a3b8hyyr	2201	6	levels	level	NNS
cord-006860-a3b8hyyr	2201	7	of	of	IN
cord-006860-a3b8hyyr	2201	8	the	the	DT
cord-006860-a3b8hyyr	2201	9	tumor	tumor	NN
cord-006860-a3b8hyyr	2201	10	marker	marker	NN
cord-006860-a3b8hyyr	2201	11	CA	CA	NNP
cord-006860-a3b8hyyr	2201	12	125	125	CD
cord-006860-a3b8hyyr	2201	13	and	and	CC
cord-006860-a3b8hyyr	2201	14	with	with	IN
cord-006860-a3b8hyyr	2201	15	the	the	DT
cord-006860-a3b8hyyr	2201	16	stage	stage	NN
cord-006860-a3b8hyyr	2201	17	of	of	IN
cord-006860-a3b8hyyr	2201	18	the	the	DT
cord-006860-a3b8hyyr	2201	19	disease	disease	NN
cord-006860-a3b8hyyr	2201	20	but	but	CC
cord-006860-a3b8hyyr	2201	21	correlations	correlation	NNS
cord-006860-a3b8hyyr	2201	22	with	with	IN
cord-006860-a3b8hyyr	2201	23	patient	patient	JJ
cord-006860-a3b8hyyr	2201	24	outcome	outcome	NN
cord-006860-a3b8hyyr	2201	25	(	(	-LRB-
cord-006860-a3b8hyyr	2201	26	disease	disease	NN
cord-006860-a3b8hyyr	2201	27	recurrence	recurrence	NN
cord-006860-a3b8hyyr	2201	28	and	and	CC
cord-006860-a3b8hyyr	2201	29	overall	overall	JJ
cord-006860-a3b8hyyr	2201	30	survival	survival	NN
cord-006860-a3b8hyyr	2201	31	)	)	-RRB-
cord-006860-a3b8hyyr	2201	32	have	have	VBP
cord-006860-a3b8hyyr	2201	33	not	not	RB
cord-006860-a3b8hyyr	2201	34	previously	previously	RB
cord-006860-a3b8hyyr	2201	35	been	be	VBN
cord-006860-a3b8hyyr	2201	36	shown	show	VBN
cord-006860-a3b8hyyr	2201	37	.	.	.
cord-006860-a3b8hyyr	2202	1	Plasma	plasma	NN
cord-006860-a3b8hyyr	2202	2	levels	level	NNS
cord-006860-a3b8hyyr	2202	3	of	of	IN
cord-006860-a3b8hyyr	2202	4	D	D	NNP
cord-006860-a3b8hyyr	2202	5	-Dimer	-dimer	NN
cord-006860-a3b8hyyr	2202	6	and	and	CC
cord-006860-a3b8hyyr	2202	7	CA	CA	NNP
cord-006860-a3b8hyyr	2202	8	125	125	CD
cord-006860-a3b8hyyr	2202	9	(	(	-LRB-
cord-006860-a3b8hyyr	2202	10	determined	determine	VBN
cord-006860-a3b8hyyr	2202	11	by	by	IN
cord-006860-a3b8hyyr	2202	12	sandwich	sandwich	NN
cord-006860-a3b8hyyr	2202	13	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	2202	14	assays	assay	NNS
cord-006860-a3b8hyyr	2202	15	}	}	-RRB-
cord-006860-a3b8hyyr	2202	16	were	be	VBD
cord-006860-a3b8hyyr	2202	17	measured	measure	VBN
cord-006860-a3b8hyyr	2202	18	prior	prior	RB
cord-006860-a3b8hyyr	2202	19	to	to	IN
cord-006860-a3b8hyyr	2202	20	treatment	treatment	NN
cord-006860-a3b8hyyr	2202	21	in	in	IN
cord-006860-a3b8hyyr	2202	22	36	36	CD
cord-006860-a3b8hyyr	2202	23	women	woman	NNS
cord-006860-a3b8hyyr	2202	24	with	with	IN
cord-006860-a3b8hyyr	2202	25	FIGO	FIGO	NNP
cord-006860-a3b8hyyr	2202	26	Stage	Stage	NNP
cord-006860-a3b8hyyr	2202	27	t	t	NN
cord-006860-a3b8hyyr	2202	28	to	to	IN
cord-006860-a3b8hyyr	2202	29	III	iii	CD
cord-006860-a3b8hyyr	2202	30	ovarian	ovarian	JJ
cord-006860-a3b8hyyr	2202	31	cancer	cancer	NN
cord-006860-a3b8hyyr	2202	32	and	and	CC
cord-006860-a3b8hyyr	2202	33	correlated	correlate	VBN
cord-006860-a3b8hyyr	2202	34	with	with	IN
cord-006860-a3b8hyyr	2202	35	tumor	tumor	NN
cord-006860-a3b8hyyr	2202	36	stage	stage	NN
cord-006860-a3b8hyyr	2202	37	,	,	,
cord-006860-a3b8hyyr	2202	38	relapse	relapse	NN
cord-006860-a3b8hyyr	2202	39	and	and	CC
cord-006860-a3b8hyyr	2202	40	overall	overall	JJ
cord-006860-a3b8hyyr	2202	41	survival	survival	NN
cord-006860-a3b8hyyr	2202	42	over	over	IN
cord-006860-a3b8hyyr	2202	43	a	a	DT
cord-006860-a3b8hyyr	2202	44	mean	mean	JJ
cord-006860-a3b8hyyr	2202	45	follow	follow	NN
cord-006860-a3b8hyyr	2202	46	-up	-up	NNS
cord-006860-a3b8hyyr	2202	47	period	period	NN
cord-006860-a3b8hyyr	2202	48	of	of	IN
cord-006860-a3b8hyyr	2202	49	28	28	CD
cord-006860-a3b8hyyr	2202	50	months	month	NNS
cord-006860-a3b8hyyr	2203	1	(	(	-LRB-
cord-006860-a3b8hyyr	2203	2	range	range	VB
cord-006860-a3b8hyyr	2203	3	16	16	CD
cord-006860-a3b8hyyr	2203	4	to	to	TO
cord-006860-a3b8hyyr	2203	5	40	40	CD
cord-006860-a3b8hyyr	2203	6	months	month	NNS
cord-006860-a3b8hyyr	2203	7	)	)	-RRB-
cord-006860-a3b8hyyr	2203	8	.	.	.
cord-006860-a3b8hyyr	2204	1	Levels	level	NNS
cord-006860-a3b8hyyr	2204	2	in	in	IN
cord-006860-a3b8hyyr	2204	3	71	71	CD
cord-006860-a3b8hyyr	2204	4	healthy	healthy	JJ
cord-006860-a3b8hyyr	2204	5	women	woman	NNS
cord-006860-a3b8hyyr	2204	6	and	and	CC
cord-006860-a3b8hyyr	2204	7	27	27	CD
cord-006860-a3b8hyyr	2204	8	patients	patient	NNS
cord-006860-a3b8hyyr	2204	9	with	with	IN
cord-006860-a3b8hyyr	2204	10	benign	benign	JJ
cord-006860-a3b8hyyr	2204	11	ovarian	ovarian	JJ
cord-006860-a3b8hyyr	2204	12	disease	disease	NN
cord-006860-a3b8hyyr	2204	13	served	serve	VBD
cord-006860-a3b8hyyr	2204	14	as	as	IN
cord-006860-a3b8hyyr	2204	15	controls	control	NNS
cord-006860-a3b8hyyr	2204	16	.	.	.
cord-006860-a3b8hyyr	2205	1	The	the	DT
cord-006860-a3b8hyyr	2205	2	occurrence	occurrence	NN
cord-006860-a3b8hyyr	2205	3	of	of	IN
cord-006860-a3b8hyyr	2205	4	deep	deep	JJ
cord-006860-a3b8hyyr	2205	5	vein	vein	NN
cord-006860-a3b8hyyr	2205	6	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2205	7	in	in	IN
cord-006860-a3b8hyyr	2205	8	the	the	DT
cord-006860-a3b8hyyr	2205	9	cancer	cancer	NN
cord-006860-a3b8hyyr	2205	10	patients	patient	NNS
cord-006860-a3b8hyyr	2205	11	was	be	VBD
cord-006860-a3b8hyyr	2205	12	also	also	RB
cord-006860-a3b8hyyr	2205	13	determined	determine	VBN
cord-006860-a3b8hyyr	2205	14	by	by	IN
cord-006860-a3b8hyyr	2205	15	impedance	impedance	NN
cord-006860-a3b8hyyr	2205	16	plethysmography	plethysmography	NN
cord-006860-a3b8hyyr	2205	17	that	that	IN
cord-006860-a3b8hyyr	2205	18	,	,	,
cord-006860-a3b8hyyr	2205	19	when	when	WRB
cord-006860-a3b8hyyr	2205	20	positive	positive	JJ
cord-006860-a3b8hyyr	2205	21	,	,	,
cord-006860-a3b8hyyr	2205	22	was	be	VBD
cord-006860-a3b8hyyr	2205	23	confirmed	confirm	VBN
cord-006860-a3b8hyyr	2205	24	by	by	IN
cord-006860-a3b8hyyr	2205	25	contrast	contrast	NN
cord-006860-a3b8hyyr	2205	26	venography	venography	NN
cord-006860-a3b8hyyr	2205	27	.	.	.
cord-006860-a3b8hyyr	2206	1	Preoperative	Preoperative	NNP
cord-006860-a3b8hyyr	2206	2	D	D	NNP
cord-006860-a3b8hyyr	2206	3	-Dimer	-dimer	NN
cord-006860-a3b8hyyr	2206	4	and	and	CC
cord-006860-a3b8hyyr	2206	5	CA	CA	NNP
cord-006860-a3b8hyyr	2206	6	i25	i25	CD
cord-006860-a3b8hyyr	2206	7	levels	level	NNS
cord-006860-a3b8hyyr	2206	8	in	in	IN
cord-006860-a3b8hyyr	2206	9	ovarian	ovarian	JJ
cord-006860-a3b8hyyr	2206	10	cancer	cancer	NN
cord-006860-a3b8hyyr	2206	11	patients	patient	NNS
cord-006860-a3b8hyyr	2206	12	were	be	VBD
cord-006860-a3b8hyyr	2206	13	statistically	statistically	RB
cord-006860-a3b8hyyr	2206	14	signfficantly	signfficantly	RB
cord-006860-a3b8hyyr	2206	15	higher	high	JJR
cord-006860-a3b8hyyr	2206	16	than	than	IN
cord-006860-a3b8hyyr	2206	17	in	in	IN
cord-006860-a3b8hyyr	2206	18	controls	control	NNS
cord-006860-a3b8hyyr	2206	19	.	.	.
cord-006860-a3b8hyyr	2207	1	Preoperative	Preoperative	NNP
cord-006860-a3b8hyyr	2207	2	cut	cut	VBD
cord-006860-a3b8hyyr	2207	3	off	off	RP
cord-006860-a3b8hyyr	2207	4	values	value	NNS
cord-006860-a3b8hyyr	2207	5	were	be	VBD
cord-006860-a3b8hyyr	2207	6	calculated	calculate	VBN
cord-006860-a3b8hyyr	2207	7	for	for	IN
cord-006860-a3b8hyyr	2207	8	the	the	DT
cord-006860-a3b8hyyr	2207	9	prediction	prediction	NN
cord-006860-a3b8hyyr	2207	10	of	of	IN
cord-006860-a3b8hyyr	2207	11	cancer	cancer	NN
cord-006860-a3b8hyyr	2207	12	relapse	relapse	NN
cord-006860-a3b8hyyr	2207	13	and	and	CC
cord-006860-a3b8hyyr	2207	14	survival	survival	NN
cord-006860-a3b8hyyr	2207	15	for	for	IN
cord-006860-a3b8hyyr	2207	16	both	both	DT
cord-006860-a3b8hyyr	2207	17	measurements	measurement	NNS
cord-006860-a3b8hyyr	2207	18	.	.	.
cord-006860-a3b8hyyr	2208	1	D	D	NNP
cord-006860-a3b8hyyr	2208	2	-Dimer	-Dimer	NNP
cord-006860-a3b8hyyr	2208	3	levels	level	NNS
cord-006860-a3b8hyyr	2208	4	above	above	IN
cord-006860-a3b8hyyr	2208	5	a	a	DT
cord-006860-a3b8hyyr	2208	6	cut	cut	NN
cord-006860-a3b8hyyr	2208	7	off	off	RP
cord-006860-a3b8hyyr	2208	8	level	level	NN
cord-006860-a3b8hyyr	2208	9	of	of	IN
cord-006860-a3b8hyyr	2208	10	2060	2060	CD
cord-006860-a3b8hyyr	2208	11	ng	ng	NN
cord-006860-a3b8hyyr	2208	12	/	/	SYM
cord-006860-a3b8hyyr	2208	13	ml	ml	NNS
cord-006860-a3b8hyyr	2208	14	were	be	VBD
cord-006860-a3b8hyyr	2208	15	statistically	statistically	RB
cord-006860-a3b8hyyr	2208	16	significantly	significantly	RB
cord-006860-a3b8hyyr	2208	17	associated	associate	VBN
cord-006860-a3b8hyyr	2208	18	with	with	IN
cord-006860-a3b8hyyr	2208	19	the	the	DT
cord-006860-a3b8hyyr	2208	20	rate	rate	NN
cord-006860-a3b8hyyr	2208	21	of	of	IN
cord-006860-a3b8hyyr	2208	22	relapse	relapse	NN
cord-006860-a3b8hyyr	2208	23	but	but	CC
cord-006860-a3b8hyyr	2208	24	CA	CA	NNP
cord-006860-a3b8hyyr	2208	25	125	125	CD
cord-006860-a3b8hyyr	2208	26	levels	level	NNS
cord-006860-a3b8hyyr	2208	27	were	be	VBD
cord-006860-a3b8hyyr	2208	28	not	not	RB
cord-006860-a3b8hyyr	2208	29	.	.	.
cord-006860-a3b8hyyr	2209	1	Deep	deep	JJ
cord-006860-a3b8hyyr	2209	2	venous	venous	JJ
cord-006860-a3b8hyyr	2209	3	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2209	4	occurred	occur	VBD
cord-006860-a3b8hyyr	2209	5	in	in	IN
cord-006860-a3b8hyyr	2209	6	33	33	CD
cord-006860-a3b8hyyr	2209	7	%	%	NN
cord-006860-a3b8hyyr	2209	8	of	of	IN
cord-006860-a3b8hyyr	2209	9	cases	case	NNS
cord-006860-a3b8hyyr	2209	10	but	but	CC
cord-006860-a3b8hyyr	2209	11	there	there	EX
cord-006860-a3b8hyyr	2209	12	was	be	VBD
cord-006860-a3b8hyyr	2209	13	no	no	DT
cord-006860-a3b8hyyr	2209	14	difference	difference	NN
cord-006860-a3b8hyyr	2209	15	between	between	IN
cord-006860-a3b8hyyr	2209	16	properafive	properafive	JJ
cord-006860-a3b8hyyr	2209	17	levels	level	NNS
cord-006860-a3b8hyyr	2209	18	of	of	IN
cord-006860-a3b8hyyr	2209	19	D	D	NNP
cord-006860-a3b8hyyr	2209	20	-Dimer	-dimer	NN
cord-006860-a3b8hyyr	2209	21	in	in	IN
cord-006860-a3b8hyyr	2209	22	patients	patient	NNS
cord-006860-a3b8hyyr	2209	23	who	who	WP
cord-006860-a3b8hyyr	2209	24	subsequently	subsequently	RB
cord-006860-a3b8hyyr	2209	25	did	do	VBD
cord-006860-a3b8hyyr	2209	26	versus	versus	IN
cord-006860-a3b8hyyr	2209	27	did	do	VBD
cord-006860-a3b8hyyr	2209	28	not	not	RB
cord-006860-a3b8hyyr	2209	29	develop	develop	VB
cord-006860-a3b8hyyr	2209	30	deep	deep	JJ
cord-006860-a3b8hyyr	2209	31	vein	vein	NN
cord-006860-a3b8hyyr	2209	32	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2209	33	.	.	.
cord-006860-a3b8hyyr	2210	1	High	high	JJ
cord-006860-a3b8hyyr	2210	2	levels	level	NNS
cord-006860-a3b8hyyr	2210	3	of	of	IN
cord-006860-a3b8hyyr	2210	4	D	d	NN
cord-006860-a3b8hyyr	2210	5	-Dimer	-dimer	NN
cord-006860-a3b8hyyr	2210	6	are	be	VBP
cord-006860-a3b8hyyr	2210	7	associated	associate	VBN
cord-006860-a3b8hyyr	2210	8	with	with	IN
cord-006860-a3b8hyyr	2210	9	more	more	RBR
cord-006860-a3b8hyyr	2210	10	advanced	advanced	JJ
cord-006860-a3b8hyyr	2210	11	disease	disease	NN
cord-006860-a3b8hyyr	2210	12	and	and	CC
cord-006860-a3b8hyyr	2210	13	with	with	IN
cord-006860-a3b8hyyr	2210	14	poor	poor	JJ
cord-006860-a3b8hyyr	2210	15	prognosis	prognosis	NN
cord-006860-a3b8hyyr	2210	16	in	in	IN
cord-006860-a3b8hyyr	2210	17	patients	patient	NNS
cord-006860-a3b8hyyr	2210	18	with	with	IN
cord-006860-a3b8hyyr	2210	19	ovarian	ovarian	JJ
cord-006860-a3b8hyyr	2210	20	cancer	cancer	NN
cord-006860-a3b8hyyr	2210	21	.	.	.
cord-006860-a3b8hyyr	2211	1	The	the	DT
cord-006860-a3b8hyyr	2211	2	high	high	JJ
cord-006860-a3b8hyyr	2211	3	levels	level	NNS
cord-006860-a3b8hyyr	2211	4	of	of	IN
cord-006860-a3b8hyyr	2211	5	D	d	NN
cord-006860-a3b8hyyr	2211	6	-Dimer	-dimer	NN
cord-006860-a3b8hyyr	2211	7	are	be	VBP
cord-006860-a3b8hyyr	2211	8	a	a	DT
cord-006860-a3b8hyyr	2211	9	biologic	biologic	JJ
cord-006860-a3b8hyyr	2211	10	feature	feature	NN
cord-006860-a3b8hyyr	2211	11	of	of	IN
cord-006860-a3b8hyyr	2211	12	the	the	DT
cord-006860-a3b8hyyr	2211	13	malignancy	malignancy	NN
cord-006860-a3b8hyyr	2211	14	itself	-PRON-	PRP
cord-006860-a3b8hyyr	2211	15	that	that	WDT
cord-006860-a3b8hyyr	2211	16	may	may	MD
cord-006860-a3b8hyyr	2211	17	be	be	VB
cord-006860-a3b8hyyr	2211	18	attributable	attributable	JJ
cord-006860-a3b8hyyr	2211	19	,	,	,
cord-006860-a3b8hyyr	2211	20	at	at	IN
cord-006860-a3b8hyyr	2211	21	least	least	JJS
cord-006860-a3b8hyyr	2211	22	in	in	IN
cord-006860-a3b8hyyr	2211	23	part	part	NN
cord-006860-a3b8hyyr	2211	24	,	,	,
cord-006860-a3b8hyyr	2211	25	to	to	IN
cord-006860-a3b8hyyr	2211	26	increased	increase	VBN
cord-006860-a3b8hyyr	2211	27	conversion	conversion	NN
cord-006860-a3b8hyyr	2211	28	of	of	IN
cord-006860-a3b8hyyr	2211	29	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	2211	30	to	to	TO
cord-006860-a3b8hyyr	2211	31	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2211	32	in	in	IN
cord-006860-a3b8hyyr	2211	33	the	the	DT
cord-006860-a3b8hyyr	2211	34	tumor	tumor	NN
cord-006860-a3b8hyyr	2211	35	bed	bed	NN
cord-006860-a3b8hyyr	2211	36	with	with	IN
cord-006860-a3b8hyyr	2211	37	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	2211	38	degradation	degradation	NN
cord-006860-a3b8hyyr	2211	39	of	of	IN
cord-006860-a3b8hyyr	2211	40	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2211	41	by	by	IN
cord-006860-a3b8hyyr	2211	42	the	the	DT
cord-006860-a3b8hyyr	2211	43	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	2211	44	mechanism	mechanism	NN
cord-006860-a3b8hyyr	2211	45	.	.	.
cord-006860-a3b8hyyr	2212	1	Thus	thus	RB
cord-006860-a3b8hyyr	2212	2	D	D	NNP
cord-006860-a3b8hyyr	2212	3	-Dimer	-Dimer	NNP
cord-006860-a3b8hyyr	2212	4	levels	level	NNS
cord-006860-a3b8hyyr	2212	5	may	may	MD
cord-006860-a3b8hyyr	2212	6	serve	serve	VB
cord-006860-a3b8hyyr	2212	7	as	as	IN
cord-006860-a3b8hyyr	2212	8	a	a	DT
cord-006860-a3b8hyyr	2212	9	marker	marker	NN
cord-006860-a3b8hyyr	2212	10	for	for	IN
cord-006860-a3b8hyyr	2212	11	overall	overall	JJ
cord-006860-a3b8hyyr	2212	12	tumor	tumor	NN
cord-006860-a3b8hyyr	2212	13	burden	burden	NN
cord-006860-a3b8hyyr	2212	14	as	as	RB
cord-006860-a3b8hyyr	2212	15	well	well	RB
cord-006860-a3b8hyyr	2212	16	as	as	IN
cord-006860-a3b8hyyr	2212	17	"	"	``
cord-006860-a3b8hyyr	2212	18	disease	disease	NN
cord-006860-a3b8hyyr	2212	19	activity	activity	NN
cord-006860-a3b8hyyr	2212	20	"	"	''
cord-006860-a3b8hyyr	2212	21	.	.	.
cord-006860-a3b8hyyr	2213	1	A	a	DT
cord-006860-a3b8hyyr	2213	2	high	high	JJ
cord-006860-a3b8hyyr	2213	3	incidence	incidence	NN
cord-006860-a3b8hyyr	2213	4	of	of	IN
cord-006860-a3b8hyyr	2213	5	deep	deep	JJ
cord-006860-a3b8hyyr	2213	6	vein	vein	NN
cord-006860-a3b8hyyr	2213	7	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2213	8	exists	exist	VBZ
cord-006860-a3b8hyyr	2213	9	in	in	IN
cord-006860-a3b8hyyr	2213	10	the	the	DT
cord-006860-a3b8hyyr	2213	11	course	course	NN
cord-006860-a3b8hyyr	2213	12	of	of	IN
cord-006860-a3b8hyyr	2213	13	the	the	DT
cord-006860-a3b8hyyr	2213	14	disease	disease	NN
cord-006860-a3b8hyyr	2213	15	in	in	IN
cord-006860-a3b8hyyr	2213	16	ovarian	ovarian	JJ
cord-006860-a3b8hyyr	2213	17	cancer	cancer	NN
cord-006860-a3b8hyyr	2213	18	patients	patient	NNS
cord-006860-a3b8hyyr	2213	19	but	but	CC
cord-006860-a3b8hyyr	2213	20	preoperative	preoperative	JJ
cord-006860-a3b8hyyr	2213	21	levels	level	NNS
cord-006860-a3b8hyyr	2213	22	of	of	IN
cord-006860-a3b8hyyr	2213	23	D	d	NN
cord-006860-a3b8hyyr	2214	1	-Dimer	-Dimer	NNS
cord-006860-a3b8hyyr	2214	2	are	be	VBP
cord-006860-a3b8hyyr	2214	3	not	not	RB
cord-006860-a3b8hyyr	2214	4	predictive	predictive	JJ
cord-006860-a3b8hyyr	2214	5	of	of	IN
cord-006860-a3b8hyyr	2214	6	this	this	DT
cord-006860-a3b8hyyr	2214	7	occurence	occurence	NN
cord-006860-a3b8hyyr	2214	8	.	.	.
cord-006860-a3b8hyyr	2215	1	yon	yon	NNP
cord-006860-a3b8hyyr	2215	2	Tempelhoff	Tempelhoff	NNP
cord-006860-a3b8hyyr	2215	3	Georg	Georg	NNP
cord-006860-a3b8hyyr	2215	4	-Friedrich	-Friedrich	NNP
cord-006860-a3b8hyyr	2215	5	,	,	,
cord-006860-a3b8hyyr	2215	6	Michael	Michael	NNP
cord-006860-a3b8hyyr	2215	7	Dietrich	Dietrich	NNP
cord-006860-a3b8hyyr	2215	8	,	,	,
cord-006860-a3b8hyyr	2215	9	Dirk	Dirk	NNP
cord-006860-a3b8hyyr	2215	10	Schneider	Schneider	NNP
cord-006860-a3b8hyyr	2215	11	,	,	,
cord-006860-a3b8hyyr	2215	12	Lothar	Lothar	NNP
cord-006860-a3b8hyyr	2215	13	Heilmann	Heilmann	NNP
cord-006860-a3b8hyyr	2215	14	.	.	.
cord-006860-a3b8hyyr	2216	1	Dept	Dept	NNP
cord-006860-a3b8hyyr	2216	2	.	.	.
cord-006860-a3b8hyyr	2217	1	Obstet	Obstet	NNP
cord-006860-a3b8hyyr	2217	2	.	.	.
cord-006860-a3b8hyyr	2218	1	Gynecol	Gynecol	NNP
cord-006860-a3b8hyyr	2218	2	.	.	.
cord-006860-a3b8hyyr	2219	1	City	City	NNP
cord-006860-a3b8hyyr	2219	2	Hospital	Hospital	NNP
cord-006860-a3b8hyyr	2219	3	of	of	IN
cord-006860-a3b8hyyr	2219	4	Ruesselsheim	Ruesselsheim	NNP
cord-006860-a3b8hyyr	2219	5	.	.	.
cord-006860-a3b8hyyr	2220	1	-Germany	-Germany	NNP
cord-006860-a3b8hyyr	2220	2	.	.	.
cord-006860-a3b8hyyr	2221	1	An	an	DT
cord-006860-a3b8hyyr	2221	2	increase	increase	NN
cord-006860-a3b8hyyr	2221	3	of	of	IN
cord-006860-a3b8hyyr	2221	4	Plasminogen	Plasminogen	NNP
cord-006860-a3b8hyyr	2221	5	Activator	Activator	NNP
cord-006860-a3b8hyyr	2221	6	Inhibitor	Inhibitor	NNP
cord-006860-a3b8hyyr	2221	7	activity	activity	NN
cord-006860-a3b8hyyr	2221	8	(	(	-LRB-
cord-006860-a3b8hyyr	2221	9	PAI	PAI	NNP
cord-006860-a3b8hyyr	2221	10	act	act	NNP
cord-006860-a3b8hyyr	2221	11	.	.	.
cord-006860-a3b8hyyr	2221	12	)	)	-RRB-
cord-006860-a3b8hyyr	2222	1	in	in	IN
cord-006860-a3b8hyyr	2222	2	the	the	DT
cord-006860-a3b8hyyr	2222	3	plasma	plasma	NN
cord-006860-a3b8hyyr	2222	4	of	of	IN
cord-006860-a3b8hyyr	2222	5	cancer	cancer	NN
cord-006860-a3b8hyyr	2222	6	patients	patient	NNS
cord-006860-a3b8hyyr	2222	7	has	have	VBZ
cord-006860-a3b8hyyr	2222	8	been	be	VBN
cord-006860-a3b8hyyr	2222	9	recently	recently	RB
cord-006860-a3b8hyyr	2222	10	discribed	discribe	VBN
cord-006860-a3b8hyyr	2222	11	.	.	.
cord-006860-a3b8hyyr	2223	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2223	2	have	have	VBP
cord-006860-a3b8hyyr	2223	3	longitudinally	longitudinally	RB
cord-006860-a3b8hyyr	2223	4	investigated	investigate	VBN
cord-006860-a3b8hyyr	2223	5	PAI	PAI	NNP
cord-006860-a3b8hyyr	2223	6	act	act	NN
cord-006860-a3b8hyyr	2223	7	.	.	.
cord-006860-a3b8hyyr	2224	1	in	in	IN
cord-006860-a3b8hyyr	2224	2	136	136	CD
cord-006860-a3b8hyyr	2224	3	patients	patient	NNS
cord-006860-a3b8hyyr	2224	4	with	with	IN
cord-006860-a3b8hyyr	2224	5	primary	primary	JJ
cord-006860-a3b8hyyr	2224	6	breast	breast	NN
cord-006860-a3b8hyyr	2224	7	cancer	cancer	NN
cord-006860-a3b8hyyr	2224	8	and	and	CC
cord-006860-a3b8hyyr	2224	9	compared	compare	VBD
cord-006860-a3b8hyyr	2224	10	the	the	DT
cord-006860-a3b8hyyr	2224	11	results	result	NNS
cord-006860-a3b8hyyr	2224	12	with	with	IN
cord-006860-a3b8hyyr	2224	13	the	the	DT
cord-006860-a3b8hyyr	2224	14	outcome	outcome	NN
cord-006860-a3b8hyyr	2224	15	of	of	IN
cord-006860-a3b8hyyr	2224	16	malignancy	malignancy	NN
cord-006860-a3b8hyyr	2224	17	.	.	.
cord-006860-a3b8hyyr	2225	1	Patients	patient	NNS
cord-006860-a3b8hyyr	2225	2	with	with	IN
cord-006860-a3b8hyyr	2225	3	untreated	untreated	JJ
cord-006860-a3b8hyyr	2225	4	primary	primary	JJ
cord-006860-a3b8hyyr	2225	5	breast	breast	NN
cord-006860-a3b8hyyr	2225	6	cancer	cancer	NN
cord-006860-a3b8hyyr	2225	7	and	and	CC
cord-006860-a3b8hyyr	2225	8	without	without	IN
cord-006860-a3b8hyyr	2225	9	proof	proof	NN
cord-006860-a3b8hyyr	2225	10	of	of	IN
cord-006860-a3b8hyyr	2225	11	metastasis	metastasis	NN
cord-006860-a3b8hyyr	2225	12	(	(	-LRB-
cord-006860-a3b8hyyr	2225	13	T	T	NNP
cord-006860-a3b8hyyr	2225	14	1	1	CD
cord-006860-a3b8hyyr	2225	15	-	-	SYM
cord-006860-a3b8hyyr	2225	16	4	4	CD
cord-006860-a3b8hyyr	2225	17	N0	N0	NNP
cord-006860-a3b8hyyr	2225	18	-	-	HYPH
cord-006860-a3b8hyyr	2225	19	2	2	CD
cord-006860-a3b8hyyr	2225	20	M0	M0	NNP
cord-006860-a3b8hyyr	2225	21	)	)	-RRB-
cord-006860-a3b8hyyr	2225	22	were	be	VBD
cord-006860-a3b8hyyr	2225	23	eligible	eligible	JJ
cord-006860-a3b8hyyr	2225	24	for	for	IN
cord-006860-a3b8hyyr	2225	25	this	this	DT
cord-006860-a3b8hyyr	2225	26	study	study	NN
cord-006860-a3b8hyyr	2225	27	.	.	.
cord-006860-a3b8hyyr	2226	1	In	in	IN
cord-006860-a3b8hyyr	2226	2	all	all	DT
cord-006860-a3b8hyyr	2226	3	patients	patient	NNS
cord-006860-a3b8hyyr	2226	4	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2226	5	tests	test	NNS
cord-006860-a3b8hyyr	2226	6	including	include	VBG
cord-006860-a3b8hyyr	2226	7	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	2226	8	{	{	-LRB-
cord-006860-a3b8hyyr	2226	9	method	method	NN
cord-006860-a3b8hyyr	2226	10	according	accord	VBG
cord-006860-a3b8hyyr	2226	11	to	to	IN
cord-006860-a3b8hyyr	2226	12	Clauss	Clauss	NNP
cord-006860-a3b8hyyr	2226	13	)	)	-RRB-
cord-006860-a3b8hyyr	2226	14	,	,	,
cord-006860-a3b8hyyr	2226	15	d	d	LS
cord-006860-a3b8hyyr	2226	16	-dimer	-dimer	NNP
cord-006860-a3b8hyyr	2226	17	(	(	-LRB-
cord-006860-a3b8hyyr	2226	18	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	2226	19	}	}	-RRB-
cord-006860-a3b8hyyr	2226	20	and	and	CC
cord-006860-a3b8hyyr	2226	21	PAl	PAl	NNP
cord-006860-a3b8hyyr	2226	22	act	act	NNP
cord-006860-a3b8hyyr	2226	23	.	.	.
cord-006860-a3b8hyyr	2227	1	(	(	-LRB-
cord-006860-a3b8hyyr	2227	2	uPA	uPA	NNP
cord-006860-a3b8hyyr	2227	3	dependent	dependent	JJ
cord-006860-a3b8hyyr	2227	4	inhibition	inhibition	NN
cord-006860-a3b8hyyr	2227	5	test	test	NN
cord-006860-a3b8hyyr	2227	6	)	)	-RRB-
cord-006860-a3b8hyyr	2227	7	were	be	VBD
cord-006860-a3b8hyyr	2227	8	performed	perform	VBN
cord-006860-a3b8hyyr	2227	9	prior	prior	RB
cord-006860-a3b8hyyr	2227	10	to	to	IN
cord-006860-a3b8hyyr	2227	11	primary	primary	JJ
cord-006860-a3b8hyyr	2227	12	operation	operation	NN
cord-006860-a3b8hyyr	2227	13	,	,	,
cord-006860-a3b8hyyr	2227	14	6	6	CD
cord-006860-a3b8hyyr	2227	15	months	month	NNS
cord-006860-a3b8hyyr	2227	16	thereafter	thereafter	RB
cord-006860-a3b8hyyr	2227	17	and	and	CC
cord-006860-a3b8hyyr	2227	18	at	at	IN
cord-006860-a3b8hyyr	2227	19	the	the	DT
cord-006860-a3b8hyyr	2227	20	time	time	NN
cord-006860-a3b8hyyr	2227	21	of	of	IN
cord-006860-a3b8hyyr	2227	22	cancer	cancer	NN
cord-006860-a3b8hyyr	2227	23	relapse	relapse	NN
cord-006860-a3b8hyyr	2227	24	.	.	.
cord-006860-a3b8hyyr	2228	1	Seventy	seventy	CD
cord-006860-a3b8hyyr	2228	2	-two	-two	HYPH
cord-006860-a3b8hyyr	2228	3	healthy	healthy	JJ
cord-006860-a3b8hyyr	2228	4	women	woman	NNS
cord-006860-a3b8hyyr	2228	5	and	and	CC
cord-006860-a3b8hyyr	2228	6	43	43	CD
cord-006860-a3b8hyyr	2228	7	patients	patient	NNS
cord-006860-a3b8hyyr	2228	8	with	with	IN
cord-006860-a3b8hyyr	2228	9	benign	benign	JJ
cord-006860-a3b8hyyr	2228	10	breast	breast	NN
cord-006860-a3b8hyyr	2228	11	disease	disease	NN
cord-006860-a3b8hyyr	2228	12	served	serve	VBD
cord-006860-a3b8hyyr	2228	13	as	as	IN
cord-006860-a3b8hyyr	2228	14	controls	control	NNS
cord-006860-a3b8hyyr	2228	15	.	.	.
cord-006860-a3b8hyyr	2229	1	During	during	IN
cord-006860-a3b8hyyr	2229	2	a	a	DT
cord-006860-a3b8hyyr	2229	3	mean	mean	JJ
cord-006860-a3b8hyyr	2229	4	follow	follow	NN
cord-006860-a3b8hyyr	2229	5	-up	-up	NNS
cord-006860-a3b8hyyr	2229	6	of	of	IN
cord-006860-a3b8hyyr	2229	7	32	32	CD
cord-006860-a3b8hyyr	2229	8	+	+	SYM
cord-006860-a3b8hyyr	2229	9	16	16	CD
cord-006860-a3b8hyyr	2229	10	months	month	NNS
cord-006860-a3b8hyyr	2229	11	34	34	CD
cord-006860-a3b8hyyr	2229	12	patients	patient	NNS
cord-006860-a3b8hyyr	2229	13	(	(	-LRB-
cord-006860-a3b8hyyr	2229	14	25	25	CD
cord-006860-a3b8hyyr	2229	15	%	%	NN
cord-006860-a3b8hyyr	2229	16	)	)	-RRB-
cord-006860-a3b8hyyr	2229	17	developed	develop	VBN
cord-006860-a3b8hyyr	2229	18	cancer	cancer	NN
cord-006860-a3b8hyyr	2229	19	recurrence	recurrence	NN
cord-006860-a3b8hyyr	2229	20	and	and	CC
cord-006860-a3b8hyyr	2229	21	13	13	CD
cord-006860-a3b8hyyr	2229	22	(	(	-LRB-
cord-006860-a3b8hyyr	2229	23	9.6	9.6	CD
cord-006860-a3b8hyyr	2229	24	%	%	NN
cord-006860-a3b8hyyr	2229	25	)	)	-RRB-
cord-006860-a3b8hyyr	2230	1	patients	patient	NNS
cord-006860-a3b8hyyr	2230	2	died	die	VBD
cord-006860-a3b8hyyr	2230	3	.	.	.
cord-006860-a3b8hyyr	2231	1	In	in	IN
cord-006860-a3b8hyyr	2231	2	all	all	DT
cord-006860-a3b8hyyr	2231	3	cancer	cancer	NN
cord-006860-a3b8hyyr	2231	4	patients	patient	NNS
cord-006860-a3b8hyyr	2231	5	preoperative	preoperative	JJ
cord-006860-a3b8hyyr	2231	6	levels	level	NNS
cord-006860-a3b8hyyr	2231	7	of	of	IN
cord-006860-a3b8hyyr	2231	8	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	2231	9	and	and	CC
cord-006860-a3b8hyyr	2231	10	PAI	PAI	NNP
cord-006860-a3b8hyyr	2231	11	act	act	NNP
cord-006860-a3b8hyyr	2231	12	.	.	.
cord-006860-a3b8hyyr	2232	1	were	be	VBD
cord-006860-a3b8hyyr	2232	2	significantly	significantly	RB
cord-006860-a3b8hyyr	2232	3	higher	high	JJR
cord-006860-a3b8hyyr	2232	4	compared	compare	VBN
cord-006860-a3b8hyyr	2232	5	to	to	IN
cord-006860-a3b8hyyr	2232	6	healthy	healthy	JJ
cord-006860-a3b8hyyr	2232	7	women	woman	NNS
cord-006860-a3b8hyyr	2232	8	and	and	CC
cord-006860-a3b8hyyr	2232	9	to	to	IN
cord-006860-a3b8hyyr	2232	10	patients	patient	NNS
cord-006860-a3b8hyyr	2232	11	with	with	IN
cord-006860-a3b8hyyr	2232	12	benign	benign	JJ
cord-006860-a3b8hyyr	2232	13	breast	breast	NN
cord-006860-a3b8hyyr	2232	14	disease	disease	NN
cord-006860-a3b8hyyr	2232	15	.	.	.
cord-006860-a3b8hyyr	2233	1	Preoperatively	Preoperatively	NNP
cord-006860-a3b8hyyr	2233	2	only	only	RB
cord-006860-a3b8hyyr	2233	3	PAl	PAl	NNS
cord-006860-a3b8hyyr	2233	4	act	act	NN
cord-006860-a3b8hyyr	2233	5	.	.	.
cord-006860-a3b8hyyr	2234	1	was	be	VBD
cord-006860-a3b8hyyr	2234	2	significantly	significantly	RB
cord-006860-a3b8hyyr	2234	3	higher	high	JJR
cord-006860-a3b8hyyr	2234	4	in	in	IN
cord-006860-a3b8hyyr	2234	5	patients	patient	NNS
cord-006860-a3b8hyyr	2234	6	with	with	IN
cord-006860-a3b8hyyr	2234	7	vs.	vs.	NN
cord-006860-a3b8hyyr	2234	8	without	without	IN
cord-006860-a3b8hyyr	2234	9	cancer	cancer	NN
cord-006860-a3b8hyyr	2234	10	recurrence	recurrence	NN
cord-006860-a3b8hyyr	2234	11	(	(	-LRB-
cord-006860-a3b8hyyr	2234	12	4.52	4.52	CD
cord-006860-a3b8hyyr	2234	13	_	_	NN
cord-006860-a3b8hyyr	2234	14	+	+	CC
cord-006860-a3b8hyyr	2235	1	1.67	1.67	CD
cord-006860-a3b8hyyr	2235	2	U	U	NNP
cord-006860-a3b8hyyr	2235	3	/	/	SYM
cord-006860-a3b8hyyr	2235	4	ml	ml	NN
cord-006860-a3b8hyyr	2235	5	vs.	vs.	NN
cord-006860-a3b8hyyr	2235	6	3.4	3.4	CD
cord-006860-a3b8hyyr	2235	7	1	1	CD
cord-006860-a3b8hyyr	2235	8	+	+	CC
cord-006860-a3b8hyyr	2236	1	1.55	1.55	CD
cord-006860-a3b8hyyr	2236	2	U	U	NNP
cord-006860-a3b8hyyr	2236	3	/	/	SYM
cord-006860-a3b8hyyr	2236	4	ml	ml	NN
cord-006860-a3b8hyyr	2236	5	;	;	:
cord-006860-a3b8hyyr	2236	6	p	p	NN
cord-006860-a3b8hyyr	2236	7	=	=	SYM
cord-006860-a3b8hyyr	2236	8	0.002	0.002	CD
cord-006860-a3b8hyyr	2236	9	)	)	-RRB-
cord-006860-a3b8hyyr	2236	10	.	.	.
cord-006860-a3b8hyyr	2237	1	In	in	IN
cord-006860-a3b8hyyr	2237	2	patients	patient	NNS
cord-006860-a3b8hyyr	2237	3	with	with	IN
cord-006860-a3b8hyyr	2237	4	later	later	JJ
cord-006860-a3b8hyyr	2237	5	recurrence	recurrence	NN
cord-006860-a3b8hyyr	2237	6	PAI	PAI	NNP
cord-006860-a3b8hyyr	2237	7	a	a	DT
cord-006860-a3b8hyyr	2237	8	~	~	NFP
cord-006860-a3b8hyyr	2237	9	t	t	NN
cord-006860-a3b8hyyr	2237	10	.	.	.
cord-006860-a3b8hyyr	2237	11	significantly	significantly	RB
cord-006860-a3b8hyyr	2237	12	dropped	drop	VBD
cord-006860-a3b8hyyr	2237	13	6	6	CD
cord-006860-a3b8hyyr	2237	14	months	month	NNS
cord-006860-a3b8hyyr	2237	15	after	after	IN
cord-006860-a3b8hyyr	2237	16	operation	operation	NN
cord-006860-a3b8hyyr	2237	17	(	(	-LRB-
cord-006860-a3b8hyyr	2237	18	p	p	NN
cord-006860-a3b8hyyr	2237	19	=	=	SYM
cord-006860-a3b8hyyr	2237	20	0.02	0.02	CD
cord-006860-a3b8hyyr	2237	21	)	)	-RRB-
cord-006860-a3b8hyyr	2237	22	and	and	CC
cord-006860-a3b8hyyr	2237	23	was	be	VBD
cord-006860-a3b8hyyr	2237	24	again	again	RB
cord-006860-a3b8hyyr	2237	25	significantly	significantly	RB
cord-006860-a3b8hyyr	2237	26	increased	increase	VBD
cord-006860-a3b8hyyr	2237	27	at	at	IN
cord-006860-a3b8hyyr	2237	28	the	the	DT
cord-006860-a3b8hyyr	2237	29	time	time	NN
cord-006860-a3b8hyyr	2237	30	of	of	IN
cord-006860-a3b8hyyr	2237	31	cancer	cancer	NN
cord-006860-a3b8hyyr	2237	32	recurrence	recurrence	NN
cord-006860-a3b8hyyr	2237	33	(	(	-LRB-
cord-006860-a3b8hyyr	2237	34	4.90	4.90	CD
cord-006860-a3b8hyyr	2237	35	_	_	NN
cord-006860-a3b8hyyr	2237	36	+	+	SYM
cord-006860-a3b8hyyr	2237	37	2.89	2.89	CD
cord-006860-a3b8hyyr	2237	38	;	;	:
cord-006860-a3b8hyyr	2237	39	p	p	NN
cord-006860-a3b8hyyr	2237	40	=	=	SYM
cord-006860-a3b8hyyr	2237	41	0.001	0.001	CD
cord-006860-a3b8hyyr	2237	42	)	)	-RRB-
cord-006860-a3b8hyyr	2237	43	.	.	.
cord-006860-a3b8hyyr	2238	1	A	a	DT
cord-006860-a3b8hyyr	2238	2	preoperative	preoperative	JJ
cord-006860-a3b8hyyr	2238	3	cut	cut	NN
cord-006860-a3b8hyyr	2238	4	off	off	RP
cord-006860-a3b8hyyr	2238	5	value	value	NN
cord-006860-a3b8hyyr	2238	6	(	(	-LRB-
cord-006860-a3b8hyyr	2238	7	calculated	calculate	VBN
cord-006860-a3b8hyyr	2238	8	via	via	IN
cord-006860-a3b8hyyr	2238	9	Cox	Cox	NNP
cord-006860-a3b8hyyr	2238	10	model	model	NN
cord-006860-a3b8hyyr	2238	11	)	)	-RRB-
cord-006860-a3b8hyyr	2238	12	of	of	IN
cord-006860-a3b8hyyr	2238	13	PAI	PAI	NNP
cord-006860-a3b8hyyr	2238	14	act	act	NNP
cord-006860-a3b8hyyr	2238	15	.	.	.
cord-006860-a3b8hyyr	2239	1	above	above	IN
cord-006860-a3b8hyyr	2239	2	3.52	3.52	CD
cord-006860-a3b8hyyr	2239	3	U	U	NNP
cord-006860-a3b8hyyr	2239	4	/	/	SYM
cord-006860-a3b8hyyr	2239	5	ml	ml	NN
cord-006860-a3b8hyyr	2239	6	was	be	VBD
cord-006860-a3b8hyyr	2239	7	significantly	significantly	RB
cord-006860-a3b8hyyr	2239	8	associated	associate	VBN
cord-006860-a3b8hyyr	2239	9	with	with	IN
cord-006860-a3b8hyyr	2239	10	the	the	DT
cord-006860-a3b8hyyr	2239	11	rate	rate	NN
cord-006860-a3b8hyyr	2239	12	of	of	IN
cord-006860-a3b8hyyr	2239	13	relapse	relapse	NN
cord-006860-a3b8hyyr	2239	14	(	(	-LRB-
cord-006860-a3b8hyyr	2239	15	tog	tog	NN
cord-006860-a3b8hyyr	2239	16	rank	rank	NN
cord-006860-a3b8hyyr	2239	17	:	:	:
cord-006860-a3b8hyyr	2239	18	p	p	NN
cord-006860-a3b8hyyr	2239	19	=	=	SYM
cord-006860-a3b8hyyr	2239	20	0.0005	0.0005	CD
cord-006860-a3b8hyyr	2239	21	)	)	-RRB-
cord-006860-a3b8hyyr	2239	22	and	and	CC
cord-006860-a3b8hyyr	2239	23	in	in	IN
cord-006860-a3b8hyyr	2239	24	70	70	CD
cord-006860-a3b8hyyr	2239	25	%	%	NN
cord-006860-a3b8hyyr	2239	26	of	of	IN
cord-006860-a3b8hyyr	2239	27	patients	patient	NNS
cord-006860-a3b8hyyr	2239	28	who	who	WP
cord-006860-a3b8hyyr	2239	29	died	die	VBD
cord-006860-a3b8hyyr	2239	30	of	of	IN
cord-006860-a3b8hyyr	2239	31	cancer	cancer	NN
cord-006860-a3b8hyyr	2239	32	preoperative	preoperative	JJ
cord-006860-a3b8hyyr	2239	33	PAI	PAI	NNP
cord-006860-a3b8hyyr	2239	34	act	act	NN
cord-006860-a3b8hyyr	2239	35	.	.	.
cord-006860-a3b8hyyr	2240	1	were	be	VBD
cord-006860-a3b8hyyr	2240	2	also	also	RB
cord-006860-a3b8hyyr	2240	3	above	above	IN
cord-006860-a3b8hyyr	2240	4	this	this	DT
cord-006860-a3b8hyyr	2240	5	cut	cut	VBD
cord-006860-a3b8hyyr	2240	6	off	off	RP
cord-006860-a3b8hyyr	2240	7	.	.	.
cord-006860-a3b8hyyr	2241	1	Impaired	impair	VBN
cord-006860-a3b8hyyr	2241	2	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	2241	3	in	in	IN
cord-006860-a3b8hyyr	2241	4	patients	patient	NNS
cord-006860-a3b8hyyr	2241	5	with	with	IN
cord-006860-a3b8hyyr	2241	6	breast	breast	NN
cord-006860-a3b8hyyr	2241	7	cancer	cancer	NN
cord-006860-a3b8hyyr	2241	8	is	be	VBZ
cord-006860-a3b8hyyr	2241	9	significantly	significantly	RB
cord-006860-a3b8hyyr	2241	10	associated	associate	VBN
cord-006860-a3b8hyyr	2241	11	with	with	IN
cord-006860-a3b8hyyr	2241	12	the	the	DT
cord-006860-a3b8hyyr	2241	13	outcome	outcome	NN
cord-006860-a3b8hyyr	2241	14	of	of	IN
cord-006860-a3b8hyyr	2241	15	cancer	cancer	NN
cord-006860-a3b8hyyr	2241	16	.	.	.
cord-006860-a3b8hyyr	2242	1	A	a	DT
cord-006860-a3b8hyyr	2242	2	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	2242	3	heparin	heparin	NN
cord-006860-a3b8hyyr	2242	4	antibody	antibody	NN
cord-006860-a3b8hyyr	2242	5	(	(	-LRB-
cord-006860-a3b8hyyr	2242	6	mab	mab	NNP
cord-006860-a3b8hyyr	2242	7	)	)	-RRB-
cord-006860-a3b8hyyr	2242	8	has	have	VBZ
cord-006860-a3b8hyyr	2242	9	been	be	VBN
cord-006860-a3b8hyyr	2242	10	raised	raise	VBN
cord-006860-a3b8hyyr	2242	11	against	against	IN
cord-006860-a3b8hyyr	2242	12	native	native	JJ
cord-006860-a3b8hyyr	2242	13	heparin	heparin	NN
cord-006860-a3b8hyyr	2242	14	using	use	VBG
cord-006860-a3b8hyyr	2242	15	a	a	DT
cord-006860-a3b8hyyr	2242	16	heparin	heparin	NN
cord-006860-a3b8hyyr	2242	17	-	-	HYPH
cord-006860-a3b8hyyr	2242	18	bovine	bovine	JJ
cord-006860-a3b8hyyr	2242	19	serum	serum	NN
cord-006860-a3b8hyyr	2242	20	albumin	albumin	NN
cord-006860-a3b8hyyr	2242	21	conjugate	conjugate	NN
cord-006860-a3b8hyyr	2242	22	prepared	prepare	VBN
cord-006860-a3b8hyyr	2242	23	by	by	IN
cord-006860-a3b8hyyr	2242	24	reductive	reductive	JJ
cord-006860-a3b8hyyr	2242	25	amination	amination	NN
cord-006860-a3b8hyyr	2242	26	.	.	.
cord-006860-a3b8hyyr	2243	1	For	for	IN
cord-006860-a3b8hyyr	2243	2	further	further	JJ
cord-006860-a3b8hyyr	2243	3	analyses	analysis	NNS
cord-006860-a3b8hyyr	2243	4	tyramine	tyramine	NN
cord-006860-a3b8hyyr	2243	5	,	,	,
cord-006860-a3b8hyyr	2243	6	which	which	WDT
cord-006860-a3b8hyyr	2243	7	was	be	VBD
cord-006860-a3b8hyyr	2243	8	covalently	covalently	RB
cord-006860-a3b8hyyr	2243	9	bound	bind	VBN
cord-006860-a3b8hyyr	2243	10	to	to	IN
cord-006860-a3b8hyyr	2243	11	low	low	JJ
cord-006860-a3b8hyyr	2243	12	molecular	molecular	JJ
cord-006860-a3b8hyyr	2243	13	mass	mass	NN
cord-006860-a3b8hyyr	2243	14	heparin	heparin	NN
cord-006860-a3b8hyyr	2243	15	by	by	IN
cord-006860-a3b8hyyr	2243	16	endP0int	endP0int	NNP
cord-006860-a3b8hyyr	2243	17	attachment	attachment	NN
cord-006860-a3b8hyyr	2244	1	(	(	-LRB-
cord-006860-a3b8hyyr	2244	2	Malsch	Malsch	NNP
cord-006860-a3b8hyyr	2244	3	R	R	NNP
cord-006860-a3b8hyyr	2244	4	et	et	FW
cord-006860-a3b8hyyr	2244	5	al	al	NNP
cord-006860-a3b8hyyr	2244	6	:	:	:
cord-006860-a3b8hyyr	2244	7	Anal	Anal	NNP
cord-006860-a3b8hyyr	2244	8	Biochem	Biochem	NNP
cord-006860-a3b8hyyr	2244	9	1994	1994	CD
cord-006860-a3b8hyyr	2244	10	;	;	:
cord-006860-a3b8hyyr	2244	11	217	217	CD
cord-006860-a3b8hyyr	2244	12	:	:	SYM
cord-006860-a3b8hyyr	2244	13	255	255	CD
cord-006860-a3b8hyyr	2244	14	-	-	HYPH
cord-006860-a3b8hyyr	2244	15	264	264	CD
cord-006860-a3b8hyyr	2244	16	)	)	-RRB-
cord-006860-a3b8hyyr	2244	17	,	,	,
cord-006860-a3b8hyyr	2244	18	was	be	VBD
cord-006860-a3b8hyyr	2244	19	labeled	label	VBN
cord-006860-a3b8hyyr	2244	20	with	with	IN
cord-006860-a3b8hyyr	2244	21	125-iodine	125-iodine	CD
cord-006860-a3b8hyyr	2244	22	at	at	IN
cord-006860-a3b8hyyr	2244	23	the	the	DT
cord-006860-a3b8hyyr	2244	24	aryl	aryl	NN
cord-006860-a3b8hyyr	2244	25	residue	residue	NN
cord-006860-a3b8hyyr	2244	26	.	.	.
cord-006860-a3b8hyyr	2245	1	The	the	DT
cord-006860-a3b8hyyr	2245	2	tracer	tracer	NN
cord-006860-a3b8hyyr	2245	3	antibody	antibody	NN
cord-006860-a3b8hyyr	2245	4	complex	complex	NN
cord-006860-a3b8hyyr	2245	5	was	be	VBD
cord-006860-a3b8hyyr	2245	6	immunoprecipitated	immunoprecipitate	VBN
cord-006860-a3b8hyyr	2245	7	by	by	IN
cord-006860-a3b8hyyr	2245	8	goat	goat	NNP
cord-006860-a3b8hyyr	2245	9	anti	anti	NNP
cord-006860-a3b8hyyr	2245	10	-	-	JJ
cord-006860-a3b8hyyr	2245	11	mouse	mouse	JJ
cord-006860-a3b8hyyr	2245	12	immunoglobuline	immunoglobuline	NNP
cord-006860-a3b8hyyr	2246	1	IgG.	IgG.	NNP
cord-006860-a3b8hyyr	2247	1	The	the	DT
cord-006860-a3b8hyyr	2247	2	mab	mab	NNP
cord-006860-a3b8hyyr	2247	3	recognized	recognize	VBD
cord-006860-a3b8hyyr	2247	4	specifically	specifically	RB
cord-006860-a3b8hyyr	2247	5	intact	intact	JJ
cord-006860-a3b8hyyr	2247	6	heparin	heparin	NN
cord-006860-a3b8hyyr	2247	7	and	and	CC
cord-006860-a3b8hyyr	2247	8	heparin	heparin	NN
cord-006860-a3b8hyyr	2247	9	fractions	fraction	NNS
cord-006860-a3b8hyyr	2247	10	.	.	.
cord-006860-a3b8hyyr	2248	1	The	the	DT
cord-006860-a3b8hyyr	2248	2	lower	low	JJR
cord-006860-a3b8hyyr	2248	3	detection	detection	NN
cord-006860-a3b8hyyr	2248	4	limit	limit	NN
cord-006860-a3b8hyyr	2248	5	of	of	IN
cord-006860-a3b8hyyr	2248	6	heparin	heparin	NN
cord-006860-a3b8hyyr	2248	7	preparations	preparation	NNS
cord-006860-a3b8hyyr	2248	8	was	be	VBD
cord-006860-a3b8hyyr	2248	9	100	100	CD
cord-006860-a3b8hyyr	2248	10	ng	ng	NN
cord-006860-a3b8hyyr	2248	11	/	/	SYM
cord-006860-a3b8hyyr	2248	12	ml	ml	NN
cord-006860-a3b8hyyr	2248	13	.	.	.
cord-006860-a3b8hyyr	2249	1	No	no	DT
cord-006860-a3b8hyyr	2249	2	cross	cross	NN
cord-006860-a3b8hyyr	2249	3	reactivity	reactivity	NN
cord-006860-a3b8hyyr	2249	4	of	of	IN
cord-006860-a3b8hyyr	2249	5	the	the	DT
cord-006860-a3b8hyyr	2249	6	mab	mab	NNP
cord-006860-a3b8hyyr	2249	7	occurred	occur	VBD
cord-006860-a3b8hyyr	2249	8	with	with	IN
cord-006860-a3b8hyyr	2249	9	other	other	JJ
cord-006860-a3b8hyyr	2249	10	glycosaminoglycans	glycosaminoglycan	NNS
cord-006860-a3b8hyyr	2249	11	such	such	JJ
cord-006860-a3b8hyyr	2249	12	as	as	IN
cord-006860-a3b8hyyr	2249	13	heparan	heparan	JJ
cord-006860-a3b8hyyr	2249	14	sulfate	sulfate	NN
cord-006860-a3b8hyyr	2249	15	,	,	,
cord-006860-a3b8hyyr	2249	16	dermatan	dermatan	NNP
cord-006860-a3b8hyyr	2249	17	sulfate	sulfate	NN
cord-006860-a3b8hyyr	2249	18	,	,	,
cord-006860-a3b8hyyr	2249	19	chondroitin	chondroitin	NN
cord-006860-a3b8hyyr	2249	20	sulfate	sulfate	NN
cord-006860-a3b8hyyr	2249	21	A	a	NN
cord-006860-a3b8hyyr	2249	22	and	and	CC
cord-006860-a3b8hyyr	2249	23	C.	C.	NNP
cord-006860-a3b8hyyr	2249	24	Oversulfated	Oversulfated	NNP
cord-006860-a3b8hyyr	2250	1	heparin	heparin	NNP
cord-006860-a3b8hyyr	2250	2	showed	show	VBD
cord-006860-a3b8hyyr	2250	3	lower	low	JJR
cord-006860-a3b8hyyr	2250	4	affinity	affinity	NN
cord-006860-a3b8hyyr	2250	5	to	to	IN
cord-006860-a3b8hyyr	2250	6	the	the	DT
cord-006860-a3b8hyyr	2250	7	antibody	antibody	NN
cord-006860-a3b8hyyr	2251	1	Hl.18	Hl.18	NNP
cord-006860-a3b8hyyr	2251	2	than	than	IN
cord-006860-a3b8hyyr	2251	3	2	2	CD
cord-006860-a3b8hyyr	2251	4	-	-	HYPH
cord-006860-a3b8hyyr	2251	5	0-and	0-and	CD
cord-006860-a3b8hyyr	2251	6	6	6	CD
cord-006860-a3b8hyyr	2251	7	-	-	HYPH
cord-006860-a3b8hyyr	2251	8	0-desulfated	0-desulfated	CD
cord-006860-a3b8hyyr	2251	9	beparin	beparin	NN
cord-006860-a3b8hyyr	2251	10	.	.	.
cord-006860-a3b8hyyr	2252	1	The	the	DT
cord-006860-a3b8hyyr	2252	2	method	method	NN
cord-006860-a3b8hyyr	2252	3	established	establish	VBN
cord-006860-a3b8hyyr	2252	4	for	for	IN
cord-006860-a3b8hyyr	2252	5	the	the	DT
cord-006860-a3b8hyyr	2252	6	purification	purification	NN
cord-006860-a3b8hyyr	2252	7	of	of	IN
cord-006860-a3b8hyyr	2252	8	the	the	DT
cord-006860-a3b8hyyr	2252	9	mab	mab	NNP
cord-006860-a3b8hyyr	2252	10	was	be	VBD
cord-006860-a3b8hyyr	2252	11	ammonium	ammonium	NN
cord-006860-a3b8hyyr	2252	12	sulfate	sulfate	NN
cord-006860-a3b8hyyr	2252	13	precipitation	precipitation	NN
cord-006860-a3b8hyyr	2252	14	with	with	IN
cord-006860-a3b8hyyr	2252	15	followed	follow	VBN
cord-006860-a3b8hyyr	2252	16	dialysis	dialysis	NN
cord-006860-a3b8hyyr	2252	17	.	.	.
cord-006860-a3b8hyyr	2253	1	SDS	SDS	NNP
cord-006860-a3b8hyyr	2253	2	-	-	HYPH
cord-006860-a3b8hyyr	2253	3	PAGE	PAGE	NNP
cord-006860-a3b8hyyr	2253	4	and	and	CC
cord-006860-a3b8hyyr	2253	5	high	high	JJ
cord-006860-a3b8hyyr	2253	6	pressure	pressure	NN
cord-006860-a3b8hyyr	2253	7	capillary	capillary	NN
cord-006860-a3b8hyyr	2253	8	electrophoresis	electrophoresis	NN
cord-006860-a3b8hyyr	2253	9	prooved	proove	VBD
cord-006860-a3b8hyyr	2253	10	the	the	DT
cord-006860-a3b8hyyr	2253	11	high	high	JJ
cord-006860-a3b8hyyr	2253	12	purity	purity	NN
cord-006860-a3b8hyyr	2253	13	of	of	IN
cord-006860-a3b8hyyr	2253	14	the	the	DT
cord-006860-a3b8hyyr	2253	15	received	receive	VBN
cord-006860-a3b8hyyr	2253	16	antibody	antibody	NN
cord-006860-a3b8hyyr	2253	17	.	.	.
cord-006860-a3b8hyyr	2254	1	The	the	DT
cord-006860-a3b8hyyr	2254	2	biological	biological	JJ
cord-006860-a3b8hyyr	2254	3	activity	activity	NN
cord-006860-a3b8hyyr	2254	4	of	of	IN
cord-006860-a3b8hyyr	2254	5	mab	mab	NNP
cord-006860-a3b8hyyr	2254	6	was	be	VBD
cord-006860-a3b8hyyr	2254	7	tested	test	VBN
cord-006860-a3b8hyyr	2254	8	by	by	IN
cord-006860-a3b8hyyr	2254	9	the	the	DT
cord-006860-a3b8hyyr	2254	10	chromogenic	chromogenic	NNP
cord-006860-a3b8hyyr	2254	11	assay	assay	NN
cord-006860-a3b8hyyr	2254	12	$	$	$
cord-006860-a3b8hyyr	2254	13	2222	2222	CD
cord-006860-a3b8hyyr	2254	14	and	and	CC
cord-006860-a3b8hyyr	2254	15	remained	remain	VBD
cord-006860-a3b8hyyr	2254	16	stabile	stabile	JJ
cord-006860-a3b8hyyr	2254	17	while	while	IN
cord-006860-a3b8hyyr	2254	18	purified	purify	VBN
cord-006860-a3b8hyyr	2254	19	.	.	.
cord-006860-a3b8hyyr	2255	1	In	in	IN
cord-006860-a3b8hyyr	2255	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	2255	3	,	,	,
cord-006860-a3b8hyyr	2255	4	the	the	DT
cord-006860-a3b8hyyr	2255	5	present	present	JJ
cord-006860-a3b8hyyr	2255	6	abstract	abstract	NN
cord-006860-a3b8hyyr	2255	7	describes	describe	VBZ
cord-006860-a3b8hyyr	2255	8	an	an	DT
cord-006860-a3b8hyyr	2255	9	purified	purify	VBN
cord-006860-a3b8hyyr	2255	10	IgG	igg	NN
cord-006860-a3b8hyyr	2255	11	1	1	CD
cord-006860-a3b8hyyr	2255	12	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	2255	13	antibody	antibody	NN
cord-006860-a3b8hyyr	2255	14	directed	direct	VBN
cord-006860-a3b8hyyr	2255	15	against	against	IN
cord-006860-a3b8hyyr	2255	16	heparin	heparin	NN
cord-006860-a3b8hyyr	2255	17	and	and	CC
cord-006860-a3b8hyyr	2255	18	heparin	heparin	NN
cord-006860-a3b8hyyr	2255	19	fractions	fraction	NNS
cord-006860-a3b8hyyr	2255	20	,	,	,
cord-006860-a3b8hyyr	2255	21	which	which	WDT
cord-006860-a3b8hyyr	2255	22	can	can	MD
cord-006860-a3b8hyyr	2255	23	be	be	VB
cord-006860-a3b8hyyr	2255	24	used	use	VBN
cord-006860-a3b8hyyr	2255	25	for	for	IN
cord-006860-a3b8hyyr	2255	26	biological	biological	JJ
cord-006860-a3b8hyyr	2255	27	measurements	measurement	NNS
cord-006860-a3b8hyyr	2255	28	.	.	.
cord-006860-a3b8hyyr	2256	1	The	the	DT
cord-006860-a3b8hyyr	2256	2	concentration	concentration	NN
cord-006860-a3b8hyyr	2256	3	of	of	IN
cord-006860-a3b8hyyr	2256	4	heparin	heparin	NN
cord-006860-a3b8hyyr	2256	5	and	and	CC
cord-006860-a3b8hyyr	2256	6	dermatan	dermatan	NNP
cord-006860-a3b8hyyr	2256	7	sulfate	sulfate	NN
cord-006860-a3b8hyyr	2256	8	in	in	IN
cord-006860-a3b8hyyr	2256	9	biological	biological	JJ
cord-006860-a3b8hyyr	2256	10	fluids	fluid	NNS
cord-006860-a3b8hyyr	2256	11	is	be	VBZ
cord-006860-a3b8hyyr	2256	12	usually	usually	RB
cord-006860-a3b8hyyr	2256	13	measured	measure	VBN
cord-006860-a3b8hyyr	2256	14	using	use	VBG
cord-006860-a3b8hyyr	2256	15	radiolabeling	radiolabeling	NN
cord-006860-a3b8hyyr	2256	16	.	.	.
cord-006860-a3b8hyyr	2257	1	For	for	IN
cord-006860-a3b8hyyr	2257	2	this	this	DT
cord-006860-a3b8hyyr	2257	3	purpose	purpose	NN
cord-006860-a3b8hyyr	2257	4	aromatic	aromatic	JJ
cord-006860-a3b8hyyr	2257	5	compounds	compound	NNS
cord-006860-a3b8hyyr	2257	6	are	be	VBP
cord-006860-a3b8hyyr	2257	7	usually	usually	RB
cord-006860-a3b8hyyr	2257	8	used	use	VBN
cord-006860-a3b8hyyr	2257	9	to	to	TO
cord-006860-a3b8hyyr	2257	10	insert	insert	VB
cord-006860-a3b8hyyr	2257	11	radioactive	radioactive	JJ
cord-006860-a3b8hyyr	2257	12	iodine	iodine	NN
cord-006860-a3b8hyyr	2257	13	labeling	labeling	NN
cord-006860-a3b8hyyr	2257	14	at	at	IN
cord-006860-a3b8hyyr	2257	15	the	the	DT
cord-006860-a3b8hyyr	2257	16	saccharide	saccharide	NN
cord-006860-a3b8hyyr	2257	17	backbone	backbone	NN
cord-006860-a3b8hyyr	2257	18	of	of	IN
cord-006860-a3b8hyyr	2257	19	the	the	DT
cord-006860-a3b8hyyr	2257	20	glycosaminoglycan	glycosaminoglycan	NN
cord-006860-a3b8hyyr	2257	21	.	.	.
cord-006860-a3b8hyyr	2258	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2258	2	developed	develop	VBD
cord-006860-a3b8hyyr	2258	3	methods	method	NNS
cord-006860-a3b8hyyr	2258	4	for	for	IN
cord-006860-a3b8hyyr	2258	5	the	the	DT
cord-006860-a3b8hyyr	2258	6	specific	specific	JJ
cord-006860-a3b8hyyr	2258	7	labeling	labeling	NN
cord-006860-a3b8hyyr	2258	8	of	of	IN
cord-006860-a3b8hyyr	2258	9	hepann	hepann	NNP
cord-006860-a3b8hyyr	2258	10	and	and	CC
cord-006860-a3b8hyyr	2258	11	dermatan	dermatan	NNP
cord-006860-a3b8hyyr	2258	12	sulfate	sulfate	NNP
cord-006860-a3b8hyyr	2258	13	at	at	IN
cord-006860-a3b8hyyr	2258	14	the	the	DT
cord-006860-a3b8hyyr	2258	15	terminal	terminal	JJ
cord-006860-a3b8hyyr	2258	16	residue	residue	NN
cord-006860-a3b8hyyr	2258	17	.	.	.
cord-006860-a3b8hyyr	2259	1	Tyramine	Tyramine	NNP
cord-006860-a3b8hyyr	2259	2	was	be	VBD
cord-006860-a3b8hyyr	2259	3	bound	bind	VBN
cord-006860-a3b8hyyr	2259	4	by	by	IN
cord-006860-a3b8hyyr	2259	5	reductive	reductive	JJ
cord-006860-a3b8hyyr	2259	6	amination	amination	NN
cord-006860-a3b8hyyr	2259	7	to	to	IN
cord-006860-a3b8hyyr	2259	8	the	the	DT
cord-006860-a3b8hyyr	2259	9	2,5	2,5	CD
cord-006860-a3b8hyyr	2259	10	anhydromannitosyl	anhydromannitosyl	NNP
cord-006860-a3b8hyyr	2259	11	end	end	NN
cord-006860-a3b8hyyr	2259	12	of	of	IN
cord-006860-a3b8hyyr	2259	13	heparin	heparin	NN
cord-006860-a3b8hyyr	2259	14	,	,	,
cord-006860-a3b8hyyr	2259	15	produced	produce	VBN
cord-006860-a3b8hyyr	2259	16	by	by	IN
cord-006860-a3b8hyyr	2259	17	nitrous	nitrous	JJ
cord-006860-a3b8hyyr	2259	18	acid	acid	NN
cord-006860-a3b8hyyr	2259	19	degradation	degradation	NN
cord-006860-a3b8hyyr	2259	20	and	and	CC
cord-006860-a3b8hyyr	2259	21	confirmed	confirm	VBN
cord-006860-a3b8hyyr	2259	22	by	by	IN
cord-006860-a3b8hyyr	2259	23	13C.NM	13c.nm	CD
cord-006860-a3b8hyyr	2259	24	R	r	NN
cord-006860-a3b8hyyr	2259	25	spectroscopy	spectroscopy	NN
cord-006860-a3b8hyyr	2259	26	.	.	.
cord-006860-a3b8hyyr	2260	1	(	(	-LRB-
cord-006860-a3b8hyyr	2260	2	Anal	Anal	NNP
cord-006860-a3b8hyyr	2260	3	Biochem	Biochem	NNP
cord-006860-a3b8hyyr	2260	4	217	217	CD
cord-006860-a3b8hyyr	2260	5	:	:	:
cord-006860-a3b8hyyr	2260	6	254	254	CD
cord-006860-a3b8hyyr	2260	7	-	-	SYM
cord-006860-a3b8hyyr	2260	8	264	264	CD
cord-006860-a3b8hyyr	2260	9	,	,	,
cord-006860-a3b8hyyr	2260	10	1994	1994	CD
cord-006860-a3b8hyyr	2260	11	)	)	-RRB-
cord-006860-a3b8hyyr	2261	1	This	this	DT
cord-006860-a3b8hyyr	2261	2	method	method	NN
cord-006860-a3b8hyyr	2261	3	was	be	VBD
cord-006860-a3b8hyyr	2261	4	also	also	RB
cord-006860-a3b8hyyr	2261	5	used	use	VBN
cord-006860-a3b8hyyr	2261	6	to	to	TO
cord-006860-a3b8hyyr	2261	7	produce	produce	VB
cord-006860-a3b8hyyr	2261	8	a	a	DT
cord-006860-a3b8hyyr	2261	9	low	low	JJ
cord-006860-a3b8hyyr	2261	10	molecular	molecular	JJ
cord-006860-a3b8hyyr	2261	11	mass	mass	NN
cord-006860-a3b8hyyr	2261	12	dermatan	dermatan	NNP
cord-006860-a3b8hyyr	2261	13	sulfate	sulfate	NNP
cord-006860-a3b8hyyr	2262	1	(	(	-LRB-
cord-006860-a3b8hyyr	2262	2	LMMD)derivative	lmmd)derivative	RB
cord-006860-a3b8hyyr	2262	3	after	after	IN
cord-006860-a3b8hyyr	2262	4	partial	partial	JJ
cord-006860-a3b8hyyr	2262	5	deacatylation	deacatylation	NN
cord-006860-a3b8hyyr	2262	6	.	.	.
cord-006860-a3b8hyyr	2263	1	In	in	IN
cord-006860-a3b8hyyr	2263	2	order	order	NN
cord-006860-a3b8hyyr	2263	3	to	to	TO
cord-006860-a3b8hyyr	2263	4	choose	choose	VB
cord-006860-a3b8hyyr	2263	5	the	the	DT
cord-006860-a3b8hyyr	2263	6	proper	proper	JJ
cord-006860-a3b8hyyr	2263	7	method	method	NN
cord-006860-a3b8hyyr	2263	8	for	for	IN
cord-006860-a3b8hyyr	2263	9	evaluating	evaluate	VBG
cord-006860-a3b8hyyr	2263	10	the	the	DT
cord-006860-a3b8hyyr	2263	11	specific	specific	JJ
cord-006860-a3b8hyyr	2263	12	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	2263	13	activity	activity	NN
cord-006860-a3b8hyyr	2263	14	in	in	IN
cord-006860-a3b8hyyr	2263	15	the	the	DT
cord-006860-a3b8hyyr	2263	16	row	row	NN
cord-006860-a3b8hyyr	2263	17	of	of	IN
cord-006860-a3b8hyyr	2263	18	chitosan	chitosan	NN
cord-006860-a3b8hyyr	2263	19	polysulphate	polysulphate	NNP
cord-006860-a3b8hyyr	2263	20	(	(	-LRB-
cord-006860-a3b8hyyr	2263	21	CP	CP	NNP
cord-006860-a3b8hyyr	2263	22	)	)	-RRB-
cord-006860-a3b8hyyr	2263	23	samples	sample	NNS
cord-006860-a3b8hyyr	2263	24	with	with	IN
cord-006860-a3b8hyyr	2263	25	different	different	JJ
cord-006860-a3b8hyyr	2263	26	degrees	degree	NNS
cord-006860-a3b8hyyr	2263	27	of	of	IN
cord-006860-a3b8hyyr	2263	28	pol3~merization	pol3~merization	NN
cord-006860-a3b8hyyr	2263	29	and	and	CC
cord-006860-a3b8hyyr	2263	30	sulphation	sulphation	NN
cord-006860-a3b8hyyr	2263	31	we	-PRON-	PRP
cord-006860-a3b8hyyr	2263	32	applied	apply	VBD
cord-006860-a3b8hyyr	2263	33	to	to	IN
cord-006860-a3b8hyyr	2263	34	Pharmaeapea	Pharmaeapea	NNP
cord-006860-a3b8hyyr	2263	35	Article	Article	NNP
cord-006860-a3b8hyyr	2263	36	(	(	-LRB-
cord-006860-a3b8hyyr	2263	37	A~	A~	NNP
cord-006860-a3b8hyyr	2263	38	)	)	-RRB-
cord-006860-a3b8hyyr	2263	39	when	when	WRB
cord-006860-a3b8hyyr	2263	40	assessing	assess	VBG
cord-006860-a3b8hyyr	2263	41	the	the	DT
cord-006860-a3b8hyyr	2263	42	ability	ability	NN
cord-006860-a3b8hyyr	2263	43	of	of	IN
cord-006860-a3b8hyyr	2263	44	direct	direct	JJ
cord-006860-a3b8hyyr	2263	45	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	2263	46	to	to	TO
cord-006860-a3b8hyyr	2263	47	depress	depress	VB
cord-006860-a3b8hyyr	2263	48	the	the	DT
cord-006860-a3b8hyyr	2263	49	coagulability	coagulability	NN
cord-006860-a3b8hyyr	2263	50	of	of	IN
cord-006860-a3b8hyyr	2263	51	recalcificated	recalcificated	JJ
cord-006860-a3b8hyyr	2263	52	sheep	sheep	NNP
cord-006860-a3b8hyyr	2263	53	blood	blood	NN
cord-006860-a3b8hyyr	2263	54	(	(	-LRB-
cord-006860-a3b8hyyr	2263	55	using	use	VBG
cord-006860-a3b8hyyr	2263	56	the	the	DT
cord-006860-a3b8hyyr	2263	57	3rd	3rd	JJ
cord-006860-a3b8hyyr	2263	58	International	International	NNP
cord-006860-a3b8hyyr	2263	59	heparin	heparin	NN
cord-006860-a3b8hyyr	2263	60	standard	standard	NN
cord-006860-a3b8hyyr	2263	61	)	)	-RRB-
cord-006860-a3b8hyyr	2263	62	,	,	,
cord-006860-a3b8hyyr	2263	63	and	and	CC
cord-006860-a3b8hyyr	2263	64	to	to	IN
cord-006860-a3b8hyyr	2263	65	measuring	measure	VBG
cord-006860-a3b8hyyr	2263	66	such	such	JJ
cord-006860-a3b8hyyr	2263	67	acti¢ity	acti¢ity	CD
cord-006860-a3b8hyyr	2263	68	as	as	IN
cord-006860-a3b8hyyr	2263	69	per	per	IN
cord-006860-a3b8hyyr	2263	70	pharmacokinetic	pharmacokinetic	JJ
cord-006860-a3b8hyyr	2263	71	model	model	NN
cord-006860-a3b8hyyr	2263	72	(	(	-LRB-
cord-006860-a3b8hyyr	2263	73	A2	A2	NNP
cord-006860-a3b8hyyr	2263	74	)	)	-RRB-
cord-006860-a3b8hyyr	2263	75	.	.	.
cord-006860-a3b8hyyr	2264	1	The	the	DT
cord-006860-a3b8hyyr	2264	2	model	model	NN
cord-006860-a3b8hyyr	2264	3	admits	admit	VBZ
cord-006860-a3b8hyyr	2264	4	the	the	DT
cord-006860-a3b8hyyr	2264	5	"	"	``
cord-006860-a3b8hyyr	2264	6	kinetics	kinetics	NN
cord-006860-a3b8hyyr	2264	7	of	of	IN
cord-006860-a3b8hyyr	2264	8	CP	cp	NN
cord-006860-a3b8hyyr	2264	9	elimination	elimination	NN
cord-006860-a3b8hyyr	2264	10	be	be	VB
cord-006860-a3b8hyyr	2264	11	linear	linear	JJ
cord-006860-a3b8hyyr	2264	12	in	in	IN
cord-006860-a3b8hyyr	2264	13	ease	ease	NN
cord-006860-a3b8hyyr	2264	14	of	of	IN
cord-006860-a3b8hyyr	2264	15	intravenous	intravenous	JJ
cord-006860-a3b8hyyr	2264	16	injection	injection	NN
cord-006860-a3b8hyyr	2264	17	to	to	IN
cord-006860-a3b8hyyr	2264	18	rabbits	rabbit	NNS
cord-006860-a3b8hyyr	2264	19	,	,	,
cord-006860-a3b8hyyr	2264	20	as	as	IN
cord-006860-a3b8hyyr	2264	21	it	-PRON-	PRP
cord-006860-a3b8hyyr	2264	22	is	be	VBZ
cord-006860-a3b8hyyr	2264	23	observed	observe	VBN
cord-006860-a3b8hyyr	2264	24	in	in	IN
cord-006860-a3b8hyyr	2264	25	heparin	heparin	NN
cord-006860-a3b8hyyr	2264	26	:	:	:
cord-006860-a3b8hyyr	2265	1	Ct=	Ct=	NNP
cord-006860-a3b8hyyr	2266	1	Co	Co	NNP
cord-006860-a3b8hyyr	2266	2	exp(-I~	exp(-I~	NNP
cord-006860-a3b8hyyr	2266	3	x	x	SYM
cord-006860-a3b8hyyr	2266	4	t	t	NNP
cord-006860-a3b8hyyr	2266	5	)	)	-RRB-
cord-006860-a3b8hyyr	2266	6	,	,	,
cord-006860-a3b8hyyr	2266	7	where	where	WRB
cord-006860-a3b8hyyr	2266	8	Ct	Ct	NNP
cord-006860-a3b8hyyr	2266	9	is	be	VBZ
cord-006860-a3b8hyyr	2266	10	CP	cp	JJ
cord-006860-a3b8hyyr	2266	11	concentration	concentration	NN
cord-006860-a3b8hyyr	2266	12	at	at	IN
cord-006860-a3b8hyyr	2266	13	the	the	DT
cord-006860-a3b8hyyr	2266	14	time	time	NN
cord-006860-a3b8hyyr	2266	15	moment	moment	NN
cord-006860-a3b8hyyr	2266	16	t	t	NNP
cord-006860-a3b8hyyr	2267	1	;	;	:
cord-006860-a3b8hyyr	2267	2	Co	Co	NNP
cord-006860-a3b8hyyr	2267	3	is	be	VBZ
cord-006860-a3b8hyyr	2267	4	CP	cp	JJ
cord-006860-a3b8hyyr	2267	5	concentration	concentration	NN
cord-006860-a3b8hyyr	2267	6	at	at	IN
cord-006860-a3b8hyyr	2267	7	the	the	DT
cord-006860-a3b8hyyr	2267	8	moment	moment	NN
cord-006860-a3b8hyyr	2267	9	of	of	IN
cord-006860-a3b8hyyr	2267	10	injection	injection	NN
cord-006860-a3b8hyyr	2267	11	;	;	:
cord-006860-a3b8hyyr	2267	12	I~	I~	NNP
cord-006860-a3b8hyyr	2267	13	is	be	VBZ
cord-006860-a3b8hyyr	2267	14	the	the	DT
cord-006860-a3b8hyyr	2267	15	elimination	elimination	NN
cord-006860-a3b8hyyr	2267	16	constant	constant	NN
cord-006860-a3b8hyyr	2267	17	.	.	.
cord-006860-a3b8hyyr	2268	1	Besides	besides	RB
cord-006860-a3b8hyyr	2268	2	,	,	,
cord-006860-a3b8hyyr	2268	3	it	-PRON-	PRP
cord-006860-a3b8hyyr	2268	4	is	be	VBZ
cord-006860-a3b8hyyr	2268	5	assumed	assume	VBN
cord-006860-a3b8hyyr	2268	6	that	that	IN
cord-006860-a3b8hyyr	2268	7	there	there	EX
cord-006860-a3b8hyyr	2268	8	is	be	VBZ
cord-006860-a3b8hyyr	2268	9	a	a	DT
cord-006860-a3b8hyyr	2268	10	linear	linear	JJ
cord-006860-a3b8hyyr	2268	11	approximation	approximation	NN
cord-006860-a3b8hyyr	2268	12	of	of	IN
cord-006860-a3b8hyyr	2268	13	the	the	DT
cord-006860-a3b8hyyr	2268	14	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	2268	15	effect	effect	NN
cord-006860-a3b8hyyr	2268	16	on	on	IN
cord-006860-a3b8hyyr	2268	17	the	the	DT
cord-006860-a3b8hyyr	2268	18	dose	dose	NN
cord-006860-a3b8hyyr	2268	19	,	,	,
cord-006860-a3b8hyyr	2268	20	which	which	WDT
cord-006860-a3b8hyyr	2268	21	finally	finally	RB
cord-006860-a3b8hyyr	2268	22	makes	make	VBZ
cord-006860-a3b8hyyr	2268	23	it	-PRON-	PRP
cord-006860-a3b8hyyr	2268	24	possible	possible	JJ
cord-006860-a3b8hyyr	2268	25	to	to	TO
cord-006860-a3b8hyyr	2268	26	calculate	calculate	VB
cord-006860-a3b8hyyr	2268	27	the	the	DT
cord-006860-a3b8hyyr	2268	28	specific	specific	JJ
cord-006860-a3b8hyyr	2268	29	actidty	actidty	NN
cord-006860-a3b8hyyr	2268	30	A2	a2	NN
cord-006860-a3b8hyyr	2268	31	:	:	:
cord-006860-a3b8hyyr	2269	1	T	T	NNP
cord-006860-a3b8hyyr	2269	2	=	=	SYM
cord-006860-a3b8hyyr	2269	3	KT	KT	NNP
cord-006860-a3b8hyyr	2269	4	Ct	Ct	NNP
cord-006860-a3b8hyyr	2270	1	+	+	CC
cord-006860-a3b8hyyr	2271	1	Tin	Tin	NNP
cord-006860-a3b8hyyr	2271	2	,	,	,
cord-006860-a3b8hyyr	2271	3	where	where	WRB
cord-006860-a3b8hyyr	2271	4	T	T	NNP
cord-006860-a3b8hyyr	2271	5	is	be	VBZ
cord-006860-a3b8hyyr	2271	6	the	the	DT
cord-006860-a3b8hyyr	2271	7	time	time	NN
cord-006860-a3b8hyyr	2271	8	of	of	IN
cord-006860-a3b8hyyr	2271	9	clot	clot	NN
cord-006860-a3b8hyyr	2271	10	formation	formation	NN
cord-006860-a3b8hyyr	2271	11	at	at	IN
cord-006860-a3b8hyyr	2271	12	different	different	JJ
cord-006860-a3b8hyyr	2271	13	tlme	tlme	NN
cord-006860-a3b8hyyr	2271	14	intervals	interval	NNS
cord-006860-a3b8hyyr	2271	15	after	after	IN
cord-006860-a3b8hyyr	2271	16	of	of	IN
cord-006860-a3b8hyyr	2271	17	CP	cp	NN
cord-006860-a3b8hyyr	2271	18	injection	injection	NN
cord-006860-a3b8hyyr	2272	1	;	;	:
cord-006860-a3b8hyyr	2272	2	T~	T~	NNP
cord-006860-a3b8hyyr	2272	3	,	,	,
cord-006860-a3b8hyyr	2272	4	is	be	VBZ
cord-006860-a3b8hyyr	2272	5	the	the	DT
cord-006860-a3b8hyyr	2272	6	time	time	NN
cord-006860-a3b8hyyr	2272	7	of	of	IN
cord-006860-a3b8hyyr	2272	8	clot	clot	NN
cord-006860-a3b8hyyr	2272	9	formation	formation	NN
cord-006860-a3b8hyyr	2272	10	prior	prior	RB
cord-006860-a3b8hyyr	2272	11	to	to	IN
cord-006860-a3b8hyyr	2272	12	CP	cp	NN
cord-006860-a3b8hyyr	2272	13	injection	injection	NN
cord-006860-a3b8hyyr	2272	14	.	.	.
cord-006860-a3b8hyyr	2273	1	T	T	NNP
cord-006860-a3b8hyyr	2273	2	value	value	NN
cord-006860-a3b8hyyr	2273	3	was	be	VBD
cord-006860-a3b8hyyr	2273	4	assessed	assess	VBN
cord-006860-a3b8hyyr	2273	5	in	in	IN
cord-006860-a3b8hyyr	2273	6	two	two	CD
cord-006860-a3b8hyyr	2273	7	tests	test	NNS
cord-006860-a3b8hyyr	2273	8	:	:	:
cord-006860-a3b8hyyr	2273	9	in	in	IN
cord-006860-a3b8hyyr	2273	10	blood	blood	NN
cord-006860-a3b8hyyr	2273	11	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2273	12	time	time	NN
cord-006860-a3b8hyyr	2273	13	(	(	-LRB-
cord-006860-a3b8hyyr	2273	14	BCT	BCT	NNP
cord-006860-a3b8hyyr	2273	15	)	)	-RRB-
cord-006860-a3b8hyyr	2273	16	and	and	CC
cord-006860-a3b8hyyr	2273	17	in	in	IN
cord-006860-a3b8hyyr	2273	18	activated	activate	VBN
cord-006860-a3b8hyyr	2273	19	partial	partial	JJ
cord-006860-a3b8hyyr	2273	20	thromboplastin	thromboplastin	NN
cord-006860-a3b8hyyr	2273	21	time	time	NN
cord-006860-a3b8hyyr	2273	22	(	(	-LRB-
cord-006860-a3b8hyyr	2273	23	APTT	APTT	NNP
cord-006860-a3b8hyyr	2273	24	)	)	-RRB-
cord-006860-a3b8hyyr	2273	25	.	.	.
cord-006860-a3b8hyyr	2274	1	No	no	DT
cord-006860-a3b8hyyr	2274	2	correlation	correlation	NN
cord-006860-a3b8hyyr	2274	3	was	be	VBD
cord-006860-a3b8hyyr	2274	4	observed	observe	VBN
cord-006860-a3b8hyyr	2274	5	between	between	IN
cord-006860-a3b8hyyr	2274	6	A1	A1	NNP
cord-006860-a3b8hyyr	2274	7	and	and	CC
cord-006860-a3b8hyyr	2274	8	A2	A2	NNP
cord-006860-a3b8hyyr	2274	9	.	.	.
cord-006860-a3b8hyyr	2275	1	At	at	IN
cord-006860-a3b8hyyr	2275	2	the	the	DT
cord-006860-a3b8hyyr	2275	3	same	same	JJ
cord-006860-a3b8hyyr	2275	4	time	time	NN
cord-006860-a3b8hyyr	2275	5	the	the	DT
cord-006860-a3b8hyyr	2275	6	values	value	NNS
cord-006860-a3b8hyyr	2275	7	of	of	IN
cord-006860-a3b8hyyr	2275	8	Ifm	Ifm	NNP
cord-006860-a3b8hyyr	2275	9	and	and	CC
cord-006860-a3b8hyyr	2275	10	the	the	DT
cord-006860-a3b8hyyr	2275	11	period	period	NN
cord-006860-a3b8hyyr	2275	12	of	of	IN
cord-006860-a3b8hyyr	2275	13	semieliminatinn	semieliminatinn	NN
cord-006860-a3b8hyyr	2275	14	(	(	-LRB-
cord-006860-a3b8hyyr	2275	15	Tvz	Tvz	NNP
cord-006860-a3b8hyyr	2275	16	)	)	-RRB-
cord-006860-a3b8hyyr	2275	17	with	with	IN
cord-006860-a3b8hyyr	2275	18	the	the	DT
cord-006860-a3b8hyyr	2275	19	use	use	NN
cord-006860-a3b8hyyr	2275	20	of	of	IN
cord-006860-a3b8hyyr	2275	21	the	the	DT
cord-006860-a3b8hyyr	2275	22	original	original	JJ
cord-006860-a3b8hyyr	2275	23	method	method	NN
cord-006860-a3b8hyyr	2275	24	that	that	WDT
cord-006860-a3b8hyyr	2275	25	were	be	VBD
cord-006860-a3b8hyyr	2275	26	obtained	obtain	VBN
cord-006860-a3b8hyyr	2275	27	with	with	IN
cord-006860-a3b8hyyr	2275	28	the	the	DT
cord-006860-a3b8hyyr	2275	29	help	help	NN
cord-006860-a3b8hyyr	2275	30	of	of	IN
cord-006860-a3b8hyyr	2275	31	the	the	DT
cord-006860-a3b8hyyr	2275	32	quantitative	quantitative	JJ
cord-006860-a3b8hyyr	2275	33	determination	determination	NN
cord-006860-a3b8hyyr	2275	34	of	of	IN
cord-006860-a3b8hyyr	2275	35	CP	CP	NNP
cord-006860-a3b8hyyr	2275	36	in	in	IN
cord-006860-a3b8hyyr	2275	37	rabbit	rabbit	NN
cord-006860-a3b8hyyr	2275	38	's	's	POS
cord-006860-a3b8hyyr	2275	39	blood	blood	NN
cord-006860-a3b8hyyr	2275	40	taken	take	VBN
cord-006860-a3b8hyyr	2275	41	at	at	IN
cord-006860-a3b8hyyr	2275	42	different	different	JJ
cord-006860-a3b8hyyr	2275	43	time	time	NN
cord-006860-a3b8hyyr	2275	44	intervals	interval	NNS
cord-006860-a3b8hyyr	2275	45	after	after	IN
cord-006860-a3b8hyyr	2275	46	injection	injection	NN
cord-006860-a3b8hyyr	2275	47	,	,	,
cord-006860-a3b8hyyr	2275	48	showed	show	VBD
cord-006860-a3b8hyyr	2275	49	a	a	DT
cord-006860-a3b8hyyr	2275	50	close	close	JJ
cord-006860-a3b8hyyr	2275	51	correlation	correlation	NN
cord-006860-a3b8hyyr	2275	52	(	(	-LRB-
cord-006860-a3b8hyyr	2275	53	1"=0,94	1"=0,94	CD
cord-006860-a3b8hyyr	2275	54	p<0,05	p<0,05	NNP
cord-006860-a3b8hyyr	2275	55	)	)	-RRB-
cord-006860-a3b8hyyr	2275	56	between	between	IN
cord-006860-a3b8hyyr	2275	57	the	the	DT
cord-006860-a3b8hyyr	2275	58	same	same	JJ
cord-006860-a3b8hyyr	2275	59	parameters	parameter	NNS
cord-006860-a3b8hyyr	2275	60	,	,	,
cord-006860-a3b8hyyr	2275	61	obtained	obtain	VBN
cord-006860-a3b8hyyr	2275	62	with	with	IN
cord-006860-a3b8hyyr	2275	63	the	the	DT
cord-006860-a3b8hyyr	2275	64	help	help	NN
cord-006860-a3b8hyyr	2275	65	of	of	IN
cord-006860-a3b8hyyr	2275	66	the	the	DT
cord-006860-a3b8hyyr	2275	67	of	of	IN
cord-006860-a3b8hyyr	2275	68	the	the	DT
cord-006860-a3b8hyyr	2275	69	pharmacokinetic	pharmacokinetic	JJ
cord-006860-a3b8hyyr	2275	70	model	model	NN
cord-006860-a3b8hyyr	2275	71	in	in	IN
cord-006860-a3b8hyyr	2275	72	BCT	BCT	NNP
cord-006860-a3b8hyyr	2275	73	test	test	NN
cord-006860-a3b8hyyr	2275	74	.	.	.
cord-006860-a3b8hyyr	2276	1	Thus	thus	RB
cord-006860-a3b8hyyr	2276	2	,	,	,
cord-006860-a3b8hyyr	2276	3	experimentally	experimentally	RB
cord-006860-a3b8hyyr	2276	4	it	-PRON-	PRP
cord-006860-a3b8hyyr	2276	5	was	be	VBD
cord-006860-a3b8hyyr	2276	6	proved	prove	VBN
cord-006860-a3b8hyyr	2276	7	that	that	IN
cord-006860-a3b8hyyr	2276	8	the	the	DT
cord-006860-a3b8hyyr	2276	9	assumption	assumption	NN
cord-006860-a3b8hyyr	2276	10	of	of	IN
cord-006860-a3b8hyyr	2276	11	the	the	DT
cord-006860-a3b8hyyr	2276	12	linear	linear	JJ
cord-006860-a3b8hyyr	2276	13	elimination	elimination	NN
cord-006860-a3b8hyyr	2276	14	and	and	CC
cord-006860-a3b8hyyr	2276	15	the	the	DT
cord-006860-a3b8hyyr	2276	16	effect	effect	NN
cord-006860-a3b8hyyr	2276	17	-	-	HYPH
cord-006860-a3b8hyyr	2276	18	dose	dose	NN
cord-006860-a3b8hyyr	2276	19	dependence	dependence	NN
cord-006860-a3b8hyyr	2276	20	was	be	VBD
cord-006860-a3b8hyyr	2276	21	true	true	JJ
cord-006860-a3b8hyyr	2276	22	,	,	,
cord-006860-a3b8hyyr	2276	23	which	which	WDT
cord-006860-a3b8hyyr	2276	24	is	be	VBZ
cord-006860-a3b8hyyr	2276	25	necessary	necessary	JJ
cord-006860-a3b8hyyr	2276	26	for	for	IN
cord-006860-a3b8hyyr	2276	27	A2	a2	NN
cord-006860-a3b8hyyr	2276	28	calculation	calculation	NN
cord-006860-a3b8hyyr	2276	29	.	.	.
cord-006860-a3b8hyyr	2277	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2277	2	recommend	recommend	VBP
cord-006860-a3b8hyyr	2277	3	to	to	TO
cord-006860-a3b8hyyr	2277	4	use	use	VB
cord-006860-a3b8hyyr	2277	5	intravenous	intravenous	JJ
cord-006860-a3b8hyyr	2277	6	injection	injection	NN
cord-006860-a3b8hyyr	2277	7	of	of	IN
cord-006860-a3b8hyyr	2277	8	the	the	DT
cord-006860-a3b8hyyr	2277	9	samples	sample	NNS
cord-006860-a3b8hyyr	2277	10	to	to	IN
cord-006860-a3b8hyyr	2277	11	animals	animal	NNS
cord-006860-a3b8hyyr	2277	12	with	with	IN
cord-006860-a3b8hyyr	2277	13	further	further	JJ
cord-006860-a3b8hyyr	2277	14	assessment	assessment	NN
cord-006860-a3b8hyyr	2277	15	of	of	IN
cord-006860-a3b8hyyr	2277	16	the	the	DT
cord-006860-a3b8hyyr	2277	17	results	result	NNS
cord-006860-a3b8hyyr	2277	18	according	accord	VBG
cord-006860-a3b8hyyr	2277	19	to	to	IN
cord-006860-a3b8hyyr	2277	20	the	the	DT
cord-006860-a3b8hyyr	2277	21	pliarmacokinetic	pliarmacokinetic	JJ
cord-006860-a3b8hyyr	2277	22	model	model	NN
cord-006860-a3b8hyyr	2277	23	to	to	TO
cord-006860-a3b8hyyr	2277	24	calculate	calculate	VB
cord-006860-a3b8hyyr	2277	25	the	the	DT
cord-006860-a3b8hyyr	2277	26	specific	specific	JJ
cord-006860-a3b8hyyr	2277	27	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	2277	28	activity	activity	NN
cord-006860-a3b8hyyr	2277	29	in	in	IN
cord-006860-a3b8hyyr	2277	30	the	the	DT
cord-006860-a3b8hyyr	2277	31	row	row	NN
cord-006860-a3b8hyyr	2277	32	of	of	IN
cord-006860-a3b8hyyr	2277	33	chemically	chemically	RB
cord-006860-a3b8hyyr	2277	34	related	relate	VBN
cord-006860-a3b8hyyr	2277	35	potential	potential	JJ
cord-006860-a3b8hyyr	2277	36	direct	direct	JJ
cord-006860-a3b8hyyr	2277	37	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	2277	38	.	.	.
cord-006860-a3b8hyyr	2278	1	In	in	IN
cord-006860-a3b8hyyr	2278	2	this	this	DT
cord-006860-a3b8hyyr	2278	3	investigation	investigation	NN
cord-006860-a3b8hyyr	2278	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	2278	5	compared	compare	VBD
cord-006860-a3b8hyyr	2278	6	the	the	DT
cord-006860-a3b8hyyr	2278	7	biological	biological	JJ
cord-006860-a3b8hyyr	2278	8	activity	activity	NN
cord-006860-a3b8hyyr	2278	9	of	of	IN
cord-006860-a3b8hyyr	2278	10	a	a	DT
cord-006860-a3b8hyyr	2278	11	Low	Low	NNP
cord-006860-a3b8hyyr	2278	12	-	-	HYPH
cord-006860-a3b8hyyr	2278	13	Molecular	Molecular	NNP
cord-006860-a3b8hyyr	2278	14	-	-	HYPH
cord-006860-a3b8hyyr	2278	15	Heparm	Heparm	NNP
cord-006860-a3b8hyyr	2278	16	(	(	-LRB-
cord-006860-a3b8hyyr	2278	17	LMW	lmw	NN
cord-006860-a3b8hyyr	2278	18	-	-	HYPH
cord-006860-a3b8hyyr	2278	19	heparin	heparin	JJ
cord-006860-a3b8hyyr	2278	20	,	,	,
cord-006860-a3b8hyyr	2279	1	Mono	Mono	NNP
cord-006860-a3b8hyyr	2279	2	Embolcx	Embolcx	NNP
cord-006860-a3b8hyyr	2279	3	®	®	POS
cord-006860-a3b8hyyr	2279	4	)	)	-RRB-
cord-006860-a3b8hyyr	2279	5	after	after	IN
cord-006860-a3b8hyyr	2279	6	intravenous	intravenous	JJ
cord-006860-a3b8hyyr	2279	7	,	,	,
cord-006860-a3b8hyyr	2279	8	subcutaneous	subcutaneous	JJ
cord-006860-a3b8hyyr	2279	9	and	and	CC
cord-006860-a3b8hyyr	2279	10	oral	oral	JJ
cord-006860-a3b8hyyr	2279	11	application	application	NN
cord-006860-a3b8hyyr	2279	12	in	in	IN
cord-006860-a3b8hyyr	2279	13	rats	rat	NNS
cord-006860-a3b8hyyr	2279	14	.	.	.
cord-006860-a3b8hyyr	2280	1	Sprague	Sprague	NNP
cord-006860-a3b8hyyr	2280	2	-	-	HYPH
cord-006860-a3b8hyyr	2280	3	Dawly	Dawly	NNP
cord-006860-a3b8hyyr	2280	4	rats	rat	NNS
cord-006860-a3b8hyyr	2280	5	were	be	VBD
cord-006860-a3b8hyyr	2280	6	anaesthetized	anaesthetize	VBN
cord-006860-a3b8hyyr	2280	7	by	by	IN
cord-006860-a3b8hyyr	2280	8	Ketamine	Ketamine	NNP
cord-006860-a3b8hyyr	2280	9	/	/	SYM
cord-006860-a3b8hyyr	2280	10	Diazepam	Diazepam	NNP
cord-006860-a3b8hyyr	2280	11	and	and	CC
cord-006860-a3b8hyyr	2280	12	the	the	DT
cord-006860-a3b8hyyr	2280	13	blood	blood	NN
cord-006860-a3b8hyyr	2280	14	samples	sample	NNS
cord-006860-a3b8hyyr	2280	15	were	be	VBD
cord-006860-a3b8hyyr	2280	16	taken	take	VBN
cord-006860-a3b8hyyr	2280	17	from	from	IN
cord-006860-a3b8hyyr	2280	18	the	the	DT
cord-006860-a3b8hyyr	2280	19	retro	retro	JJ
cord-006860-a3b8hyyr	2280	20	orbital	orbital	JJ
cord-006860-a3b8hyyr	2280	21	sinuus	sinuus	NN
cord-006860-a3b8hyyr	2280	22	.	.	.
cord-006860-a3b8hyyr	2281	1	150	150	CD
cord-006860-a3b8hyyr	2282	1	aXa	aXa	NNP
cord-006860-a3b8hyyr	2282	2	U	U	NNP
cord-006860-a3b8hyyr	2282	3	/	/	SYM
cord-006860-a3b8hyyr	2282	4	kg	kg	NN
cord-006860-a3b8hyyr	2282	5	body	body	NN
cord-006860-a3b8hyyr	2282	6	weight	weight	NN
cord-006860-a3b8hyyr	2282	7	of	of	IN
cord-006860-a3b8hyyr	2282	8	the	the	DT
cord-006860-a3b8hyyr	2282	9	LMW	lmw	NN
cord-006860-a3b8hyyr	2282	10	-	-	HYPH
cord-006860-a3b8hyyr	2282	11	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	2282	12	were	be	VBD
cord-006860-a3b8hyyr	2282	13	injected	inject	VBN
cord-006860-a3b8hyyr	2282	14	intravenously	intravenously	RB
cord-006860-a3b8hyyr	2282	15	and	and	CC
cord-006860-a3b8hyyr	2282	16	subcutaneously	subcutaneously	RB
cord-006860-a3b8hyyr	2282	17	to	to	IN
cord-006860-a3b8hyyr	2282	18	10	10	CD
cord-006860-a3b8hyyr	2282	19	rats	rat	NNS
cord-006860-a3b8hyyr	2282	20	each	each	DT
cord-006860-a3b8hyyr	2282	21	.	.	.
cord-006860-a3b8hyyr	2283	1	Between	between	IN
cord-006860-a3b8hyyr	2283	2	3	3	CD
cord-006860-a3b8hyyr	2283	3	minutes	minute	NNS
cord-006860-a3b8hyyr	2283	4	and	and	CC
cord-006860-a3b8hyyr	2283	5	10	10	CD
cord-006860-a3b8hyyr	2283	6	hours	hour	NNS
cord-006860-a3b8hyyr	2283	7	after	after	IN
cord-006860-a3b8hyyr	2283	8	injection	injection	NN
cord-006860-a3b8hyyr	2283	9	serial	serial	JJ
cord-006860-a3b8hyyr	2283	10	blood	blood	NN
cord-006860-a3b8hyyr	2283	11	samples	sample	NNS
cord-006860-a3b8hyyr	2283	12	were	be	VBD
cord-006860-a3b8hyyr	2283	13	taken	take	VBN
cord-006860-a3b8hyyr	2283	14	.	.	.
cord-006860-a3b8hyyr	2284	1	200	200	CD
cord-006860-a3b8hyyr	2284	2	mg	mg	NNP
cord-006860-a3b8hyyr	2284	3	/	/	SYM
cord-006860-a3b8hyyr	2284	4	kg	kg	NNP
cord-006860-a3b8hyyr	2284	5	(	(	-LRB-
cord-006860-a3b8hyyr	2284	6	20.000	20.000	CD
cord-006860-a3b8hyyr	2285	1	aXa	aXa	NNP
cord-006860-a3b8hyyr	2285	2	U	U	NNP
cord-006860-a3b8hyyr	2285	3	/	/	SYM
cord-006860-a3b8hyyr	2285	4	kg	kg	NNP
cord-006860-a3b8hyyr	2285	5	)	)	-RRB-
cord-006860-a3b8hyyr	2285	6	body	body	NN
cord-006860-a3b8hyyr	2285	7	weight	weight	NN
cord-006860-a3b8hyyr	2285	8	of	of	IN
cord-006860-a3b8hyyr	2285	9	the	the	DT
cord-006860-a3b8hyyr	2285	10	LMW	lmw	NN
cord-006860-a3b8hyyr	2285	11	-	-	HYPH
cord-006860-a3b8hyyr	2285	12	heparin	heparin	NN
cord-006860-a3b8hyyr	2285	13	were	be	VBD
cord-006860-a3b8hyyr	2285	14	applicated	applicate	VBN
cord-006860-a3b8hyyr	2285	15	orally	orally	RB
cord-006860-a3b8hyyr	2285	16	using	use	VBG
cord-006860-a3b8hyyr	2285	17	a	a	DT
cord-006860-a3b8hyyr	2285	18	stomach	stomach	NN
cord-006860-a3b8hyyr	2285	19	tube	tube	NN
cord-006860-a3b8hyyr	2285	20	.	.	.
cord-006860-a3b8hyyr	2286	1	Blood	blood	NN
cord-006860-a3b8hyyr	2286	2	samples	sample	NNS
cord-006860-a3b8hyyr	2286	3	were	be	VBD
cord-006860-a3b8hyyr	2286	4	taken	take	VBN
cord-006860-a3b8hyyr	2286	5	between	between	IN
cord-006860-a3b8hyyr	2286	6	1	1	CD
cord-006860-a3b8hyyr	2286	7	and	and	CC
cord-006860-a3b8hyyr	2286	8	24	24	CD
cord-006860-a3b8hyyr	2286	9	hours	hour	NNS
cord-006860-a3b8hyyr	2286	10	after	after	IN
cord-006860-a3b8hyyr	2286	11	oral	oral	JJ
cord-006860-a3b8hyyr	2286	12	application	application	NN
cord-006860-a3b8hyyr	2286	13	.	.	.
cord-006860-a3b8hyyr	2287	1	The	the	DT
cord-006860-a3b8hyyr	2287	2	antifactor	antifactor	NN
cord-006860-a3b8hyyr	2287	3	Xa	Xa	NNP
cord-006860-a3b8hyyr	2287	4	and	and	CC
cord-006860-a3b8hyyr	2287	5	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	2287	6	activities	activity	NNS
cord-006860-a3b8hyyr	2287	7	of	of	IN
cord-006860-a3b8hyyr	2287	8	the	the	DT
cord-006860-a3b8hyyr	2287	9	plasma	plasma	NN
cord-006860-a3b8hyyr	2287	10	samples	sample	NNS
cord-006860-a3b8hyyr	2287	11	were	be	VBD
cord-006860-a3b8hyyr	2287	12	measured	measure	VBN
cord-006860-a3b8hyyr	2287	13	,	,	,
cord-006860-a3b8hyyr	2287	14	using	use	VBG
cord-006860-a3b8hyyr	2287	15	ehromogenic	ehromogenic	NNP
cord-006860-a3b8hyyr	2287	16	assays	assay	NNS
cord-006860-a3b8hyyr	2287	17	and	and	CC
cord-006860-a3b8hyyr	2287	18	the	the	DT
cord-006860-a3b8hyyr	2287	19	substances	substance	NNS
cord-006860-a3b8hyyr	2287	20	S	S	NNP
cord-006860-a3b8hyyr	2287	21	2222	2222	CD
cord-006860-a3b8hyyr	2287	22	and	and	CC
cord-006860-a3b8hyyr	2287	23	S	s	NN
cord-006860-a3b8hyyr	2287	24	2238	2238	CD
cord-006860-a3b8hyyr	2287	25	(	(	-LRB-
cord-006860-a3b8hyyr	2287	26	Kabi	Kabi	NNP
cord-006860-a3b8hyyr	2287	27	Vitmm	Vitmm	NNP
cord-006860-a3b8hyyr	2287	28	)	)	-RRB-
cord-006860-a3b8hyyr	2287	29	.	.	.
cord-006860-a3b8hyyr	2288	1	After	after	IN
cord-006860-a3b8hyyr	2288	2	i.v	i.v	NNP
cord-006860-a3b8hyyr	2288	3	.	.	.
cord-006860-a3b8hyyr	2288	4	injection	injection	NN
cord-006860-a3b8hyyr	2288	5	the	the	DT
cord-006860-a3b8hyyr	2288	6	maximum	maximum	JJ
cord-006860-a3b8hyyr	2288	7	aXa	axa	NN
cord-006860-a3b8hyyr	2288	8	and	and	CC
cord-006860-a3b8hyyr	2288	9	alia	alia	NNP
cord-006860-a3b8hyyr	2288	10	activities	activity	NNS
cord-006860-a3b8hyyr	2288	11	were	be	VBD
cord-006860-a3b8hyyr	2288	12	2.8	2.8	CD
cord-006860-a3b8hyyr	2288	13	aXa	aXa	NNP
cord-006860-a3b8hyyr	2288	14	U	U	NNP
cord-006860-a3b8hyyr	2288	15	/	/	SYM
cord-006860-a3b8hyyr	2288	16	ml	ml	NNS
cord-006860-a3b8hyyr	2288	17	and	and	CC
cord-006860-a3b8hyyr	2288	18	0.8	0.8	CD
cord-006860-a3b8hyyr	2288	19	aIIa	aIIa	NNS
cord-006860-a3b8hyyr	2288	20	U	u	NN
cord-006860-a3b8hyyr	2288	21	/	/	SYM
cord-006860-a3b8hyyr	2288	22	nil	nil	NN
cord-006860-a3b8hyyr	2288	23	respectively	respectively	RB
cord-006860-a3b8hyyr	2288	24	.	.	.
cord-006860-a3b8hyyr	2289	1	After	after	IN
cord-006860-a3b8hyyr	2289	2	s.c	s.c	NNP
cord-006860-a3b8hyyr	2289	3	.	.	NNP
cord-006860-a3b8hyyr	2289	4	application	application	NN
cord-006860-a3b8hyyr	2289	5	the	the	DT
cord-006860-a3b8hyyr	2289	6	antifactor	antifactor	NNP
cord-006860-a3b8hyyr	2290	1	Xa	Xa	NNP
cord-006860-a3b8hyyr	2290	2	activity	activity	NN
cord-006860-a3b8hyyr	2290	3	of	of	IN
cord-006860-a3b8hyyr	2290	4	the	the	DT
cord-006860-a3b8hyyr	2290	5	LMW	lmw	NN
cord-006860-a3b8hyyr	2290	6	-	-	HYPH
cord-006860-a3b8hyyr	2290	7	heparin	heparin	NN
cord-006860-a3b8hyyr	2290	8	showed	show	VBD
cord-006860-a3b8hyyr	2290	9	a	a	DT
cord-006860-a3b8hyyr	2290	10	maximum	maximum	NN
cord-006860-a3b8hyyr	2290	11	of	of	IN
cord-006860-a3b8hyyr	2290	12	0.5	0.5	CD
cord-006860-a3b8hyyr	2291	1	aXa	aXa	NNP
cord-006860-a3b8hyyr	2291	2	U	U	NNP
cord-006860-a3b8hyyr	2291	3	/	/	SYM
cord-006860-a3b8hyyr	2291	4	ml	ml	XX
cord-006860-a3b8hyyr	2291	5	atter	atter	NN
cord-006860-a3b8hyyr	2291	6	120	120	CD
cord-006860-a3b8hyyr	2291	7	minuteS.	minutes.	NN
cord-006860-a3b8hyyr	2292	1	The	the	DT
cord-006860-a3b8hyyr	2292	2	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	2292	3	activity	activity	NN
cord-006860-a3b8hyyr	2292	4	exhibited	exhibit	VBD
cord-006860-a3b8hyyr	2292	5	an	an	DT
cord-006860-a3b8hyyr	2292	6	eatiier	eatii	JJR
cord-006860-a3b8hyyr	2292	7	maximum	maximum	JJ
cord-006860-a3b8hyyr	2292	8	activity	activity	NN
cord-006860-a3b8hyyr	2292	9	of	of	IN
cord-006860-a3b8hyyr	2292	10	0.2	0.2	CD
cord-006860-a3b8hyyr	2292	11	alia	alia	NNP
cord-006860-a3b8hyyr	2292	12	U	U	NNP
cord-006860-a3b8hyyr	2292	13	/	/	SYM
cord-006860-a3b8hyyr	2292	14	nil	nil	NN
cord-006860-a3b8hyyr	2292	15	60	60	CD
cord-006860-a3b8hyyr	2292	16	minutes	minute	NNS
cord-006860-a3b8hyyr	2292	17	after	after	IN
cord-006860-a3b8hyyr	2292	18	injection	injection	NN
cord-006860-a3b8hyyr	2292	19	.	.	.
cord-006860-a3b8hyyr	2293	1	After	after	IN
cord-006860-a3b8hyyr	2293	2	the	the	DT
cord-006860-a3b8hyyr	2293	3	oral	oral	JJ
cord-006860-a3b8hyyr	2293	4	application	application	NN
cord-006860-a3b8hyyr	2293	5	no	no	DT
cord-006860-a3b8hyyr	2293	6	increase	increase	NN
cord-006860-a3b8hyyr	2293	7	of	of	IN
cord-006860-a3b8hyyr	2293	8	the	the	DT
cord-006860-a3b8hyyr	2293	9	aXa	axa	NN
cord-006860-a3b8hyyr	2293	10	or	or	CC
cord-006860-a3b8hyyr	2293	11	alia	alia	NNP
cord-006860-a3b8hyyr	2293	12	activities	activity	NNS
cord-006860-a3b8hyyr	2293	13	was	be	VBD
cord-006860-a3b8hyyr	2293	14	measured	measure	VBN
cord-006860-a3b8hyyr	2293	15	.	.	.
cord-006860-a3b8hyyr	2294	1	The	the	DT
cord-006860-a3b8hyyr	2294	2	LMW	lmw	NN
cord-006860-a3b8hyyr	2294	3	-	-	HYPH
cord-006860-a3b8hyyr	2294	4	heparin	heparin	NN
cord-006860-a3b8hyyr	2294	5	has	have	VBZ
cord-006860-a3b8hyyr	2294	6	a	a	DT
cord-006860-a3b8hyyr	2294	7	high	high	JJ
cord-006860-a3b8hyyr	2294	8	antifaetor	antifaetor	NN
cord-006860-a3b8hyyr	2294	9	Xa	Xa	NNP
cord-006860-a3b8hyyr	2294	10	and	and	CC
cord-006860-a3b8hyyr	2294	11	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	2294	12	activity	activity	NN
cord-006860-a3b8hyyr	2294	13	after	after	IN
cord-006860-a3b8hyyr	2294	14	i.v	i.v	NNP
cord-006860-a3b8hyyr	2294	15	.	.	NNP
cord-006860-a3b8hyyr	2294	16	and	and	CC
cord-006860-a3b8hyyr	2294	17	s.c	s.c	NNP
cord-006860-a3b8hyyr	2294	18	.	.	NNP
cord-006860-a3b8hyyr	2294	19	injection	injection	NN
cord-006860-a3b8hyyr	2294	20	.	.	.
cord-006860-a3b8hyyr	2295	1	After	after	IN
cord-006860-a3b8hyyr	2295	2	oral	oral	JJ
cord-006860-a3b8hyyr	2295	3	application	application	NN
cord-006860-a3b8hyyr	2295	4	no	no	DT
cord-006860-a3b8hyyr	2295	5	activity	activity	NN
cord-006860-a3b8hyyr	2295	6	of	of	IN
cord-006860-a3b8hyyr	2295	7	the	the	DT
cord-006860-a3b8hyyr	2295	8	LMW	lmw	NN
cord-006860-a3b8hyyr	2295	9	-	-	HYPH
cord-006860-a3b8hyyr	2295	10	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	2295	11	was	be	VBD
cord-006860-a3b8hyyr	2295	12	measurable	measurable	JJ
cord-006860-a3b8hyyr	2295	13	.	.	.
cord-006860-a3b8hyyr	2296	1	These	these	DT
cord-006860-a3b8hyyr	2296	2	results	result	NNS
cord-006860-a3b8hyyr	2296	3	implicate	implicate	VBP
cord-006860-a3b8hyyr	2296	4	that	that	IN
cord-006860-a3b8hyyr	2296	5	fractionated	fractionate	VBN
cord-006860-a3b8hyyr	2296	6	heparin	heparin	NN
cord-006860-a3b8hyyr	2296	7	is	be	VBZ
cord-006860-a3b8hyyr	2296	8	not	not	RB
cord-006860-a3b8hyyr	2296	9	absorbed	absorb	VBN
cord-006860-a3b8hyyr	2296	10	after	after	IN
cord-006860-a3b8hyyr	2296	11	oral	oral	JJ
cord-006860-a3b8hyyr	2296	12	application	application	NN
cord-006860-a3b8hyyr	2296	13	or	or	CC
cord-006860-a3b8hyyr	2296	14	is	be	VBZ
cord-006860-a3b8hyyr	2296	15	inactivated	inactivate	VBN
cord-006860-a3b8hyyr	2296	16	in	in	IN
cord-006860-a3b8hyyr	2296	17	the	the	DT
cord-006860-a3b8hyyr	2296	18	gastrointestinal	gastrointestinal	JJ
cord-006860-a3b8hyyr	2296	19	tract	tract	NN
cord-006860-a3b8hyyr	2296	20	.	.	.
cord-006860-a3b8hyyr	2297	1	To	to	TO
cord-006860-a3b8hyyr	2297	2	improve	improve	VB
cord-006860-a3b8hyyr	2297	3	the	the	DT
cord-006860-a3b8hyyr	2297	4	activity	activity	NN
cord-006860-a3b8hyyr	2297	5	after	after	IN
cord-006860-a3b8hyyr	2297	6	oral	oral	JJ
cord-006860-a3b8hyyr	2297	7	application	application	NN
cord-006860-a3b8hyyr	2297	8	modified	modify	VBN
cord-006860-a3b8hyyr	2297	9	hepatins	hepatin	NNS
cord-006860-a3b8hyyr	2297	10	have	have	VBP
cord-006860-a3b8hyyr	2297	11	to	to	TO
cord-006860-a3b8hyyr	2297	12	be	be	VB
cord-006860-a3b8hyyr	2297	13	synthesized	synthesize	VBN
cord-006860-a3b8hyyr	2297	14	.	.	.
cord-006860-a3b8hyyr	2298	1	In	in	IN
cord-006860-a3b8hyyr	2298	2	an	an	DT
cord-006860-a3b8hyyr	2298	3	in	in	FW
cord-006860-a3b8hyyr	2298	4	vitro	vitro	FW
cord-006860-a3b8hyyr	2298	5	study	study	VB
cord-006860-a3b8hyyr	2298	6	the	the	DT
cord-006860-a3b8hyyr	2298	7	effect	effect	NN
cord-006860-a3b8hyyr	2298	8	of	of	IN
cord-006860-a3b8hyyr	2298	9	various	various	JJ
cord-006860-a3b8hyyr	2298	10	heparin	heparin	NN
cord-006860-a3b8hyyr	2298	11	derivatives	derivative	NNS
cord-006860-a3b8hyyr	2298	12	(	(	-LRB-
cord-006860-a3b8hyyr	2298	13	calciparin	calciparin	NNP
cord-006860-a3b8hyyr	2298	14	,	,	,
cord-006860-a3b8hyyr	2298	15	fraxiparin	fraxiparin	NNP
cord-006860-a3b8hyyr	2298	16	,	,	,
cord-006860-a3b8hyyr	2298	17	CY	CY	NNP
cord-006860-a3b8hyyr	2298	18	222	222	CD
cord-006860-a3b8hyyr	2298	19	,	,	,
cord-006860-a3b8hyyr	2298	20	CY	CY	NNP
cord-006860-a3b8hyyr	2298	21	231	231	CD
cord-006860-a3b8hyyr	2298	22	,	,	,
cord-006860-a3b8hyyr	2298	23	astenose	astenose	NN
cord-006860-a3b8hyyr	2298	24	,	,	,
cord-006860-a3b8hyyr	2298	25	hexasaccharide	hexasaccharide	NN
cord-006860-a3b8hyyr	2298	26	,	,	,
cord-006860-a3b8hyyr	2298	27	SSH	SSH	NNP
cord-006860-a3b8hyyr	2298	28	14	14	CD
cord-006860-a3b8hyyr	2298	29	)	)	-RRB-
cord-006860-a3b8hyyr	2298	30	on	on	IN
cord-006860-a3b8hyyr	2298	31	thrombin	thrombin	NN
cord-006860-a3b8hyyr	2298	32	-	-	HYPH
cord-006860-a3b8hyyr	2298	33	and	and	CC
cord-006860-a3b8hyyr	2298	34	ADP	ADP	NNP
cord-006860-a3b8hyyr	2298	35	-	-	HYPH
cord-006860-a3b8hyyr	2298	36	induced	induce	VBN
cord-006860-a3b8hyyr	2298	37	platelet	platelet	NN
cord-006860-a3b8hyyr	2298	38	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2298	39	as	as	RB
cord-006860-a3b8hyyr	2298	40	well	well	RB
cord-006860-a3b8hyyr	2298	41	as	as	IN
cord-006860-a3b8hyyr	2298	42	on	on	IN
cord-006860-a3b8hyyr	2298	43	ADPmediated	ADPmediated	NNP
cord-006860-a3b8hyyr	2298	44	platelet	platelet	NN
cord-006860-a3b8hyyr	2298	45	activation	activation	NN
cord-006860-a3b8hyyr	2298	46	in	in	IN
cord-006860-a3b8hyyr	2298	47	whole	whole	JJ
cord-006860-a3b8hyyr	2298	48	blood	blood	NN
cord-006860-a3b8hyyr	2298	49	was	be	VBD
cord-006860-a3b8hyyr	2298	50	investigated	investigate	VBN
cord-006860-a3b8hyyr	2298	51	.	.	.
cord-006860-a3b8hyyr	2299	1	All	all	DT
cord-006860-a3b8hyyr	2299	2	heparin	heparin	NN
cord-006860-a3b8hyyr	2299	3	derivatives	derivative	NNS
cord-006860-a3b8hyyr	2299	4	caused	cause	VBD
cord-006860-a3b8hyyr	2299	5	a	a	DT
cord-006860-a3b8hyyr	2299	6	concentration	concentration	NN
cord-006860-a3b8hyyr	2299	7	-	-	HYPH
cord-006860-a3b8hyyr	2299	8	dependent	dependent	JJ
cord-006860-a3b8hyyr	2299	9	inhibition	inhibition	NN
cord-006860-a3b8hyyr	2299	10	of	of	IN
cord-006860-a3b8hyyr	2299	11	thrombin	thrombin	NN
cord-006860-a3b8hyyr	2299	12	-	-	HYPH
cord-006860-a3b8hyyr	2299	13	induced	induce	VBN
cord-006860-a3b8hyyr	2299	14	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2299	15	of	of	IN
cord-006860-a3b8hyyr	2299	16	washed	washed	JJ
cord-006860-a3b8hyyr	2299	17	platelets	platelet	NNS
cord-006860-a3b8hyyr	2299	18	.	.	.
cord-006860-a3b8hyyr	2300	1	Calciparin	Calciparin	NNP
cord-006860-a3b8hyyr	2300	2	and	and	CC
cord-006860-a3b8hyyr	2300	3	astenose	astenose	NNP
cord-006860-a3b8hyyr	2300	4	were	be	VBD
cord-006860-a3b8hyyr	2300	5	found	find	VBN
cord-006860-a3b8hyyr	2300	6	to	to	TO
cord-006860-a3b8hyyr	2300	7	be	be	VB
cord-006860-a3b8hyyr	2300	8	the	the	DT
cord-006860-a3b8hyyr	2300	9	most	most	RBS
cord-006860-a3b8hyyr	2300	10	effective	effective	JJ
cord-006860-a3b8hyyr	2300	11	compounds	compound	NNS
cord-006860-a3b8hyyr	2300	12	with	with	IN
cord-006860-a3b8hyyr	2300	13	IC5o	IC5o	NNP
cord-006860-a3b8hyyr	2300	14	values	value	NNS
cord-006860-a3b8hyyr	2300	15	of	of	IN
cord-006860-a3b8hyyr	2300	16	0.67	0.67	CD
cord-006860-a3b8hyyr	2300	17	and	and	CC
cord-006860-a3b8hyyr	2300	18	1.2	1.2	CD
cord-006860-a3b8hyyr	2300	19	p	p	NN
cord-006860-a3b8hyyr	2300	20	,	,	,
cord-006860-a3b8hyyr	2300	21	mol	mol	NNP
cord-006860-a3b8hyyr	2300	22	/	/	SYM
cord-006860-a3b8hyyr	2300	23	l	l	NNP
cord-006860-a3b8hyyr	2300	24	,	,	,
cord-006860-a3b8hyyr	2300	25	resp	resp	NNP
cord-006860-a3b8hyyr	2300	26	.	.	NNP
cord-006860-a3b8hyyr	2300	27	;	;	:
cord-006860-a3b8hyyr	2300	28	higher	high	JJR
cord-006860-a3b8hyyr	2300	29	concentrations	concentration	NNS
cord-006860-a3b8hyyr	2300	30	(	(	-LRB-
cord-006860-a3b8hyyr	2300	31	5	5	CD
cord-006860-a3b8hyyr	2300	32	-	-	SYM
cord-006860-a3b8hyyr	2300	33	30	30	CD
cord-006860-a3b8hyyr	2300	34	times	time	NNS
cord-006860-a3b8hyyr	2300	35	)	)	-RRB-
cord-006860-a3b8hyyr	2300	36	were	be	VBD
cord-006860-a3b8hyyr	2300	37	required	require	VBN
cord-006860-a3b8hyyr	2300	38	for	for	IN
cord-006860-a3b8hyyr	2300	39	the	the	DT
cord-006860-a3b8hyyr	2300	40	other	other	JJ
cord-006860-a3b8hyyr	2300	41	compounds	compound	NNS
cord-006860-a3b8hyyr	2300	42	.	.	.
cord-006860-a3b8hyyr	2301	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	2301	2	,	,	,
cord-006860-a3b8hyyr	2301	3	the	the	DT
cord-006860-a3b8hyyr	2301	4	heparin	heparin	JJ
cord-006860-a3b8hyyr	2301	5	derivatives	derivative	NNS
cord-006860-a3b8hyyr	2301	6	were	be	VBD
cord-006860-a3b8hyyr	2301	7	studied	study	VBN
cord-006860-a3b8hyyr	2301	8	with	with	IN
cord-006860-a3b8hyyr	2301	9	regard	regard	NN
cord-006860-a3b8hyyr	2301	10	to	to	IN
cord-006860-a3b8hyyr	2301	11	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2301	12	potentiating	potentiate	VBG
cord-006860-a3b8hyyr	2301	13	effect	effect	NN
cord-006860-a3b8hyyr	2301	14	on	on	IN
cord-006860-a3b8hyyr	2301	15	ADP	ADP	NNP
cord-006860-a3b8hyyr	2301	16	-	-	HYPH
cord-006860-a3b8hyyr	2301	17	induced	induce	VBN
cord-006860-a3b8hyyr	2301	18	platelet	platelet	NN
cord-006860-a3b8hyyr	2301	19	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2301	20	.	.	.
cord-006860-a3b8hyyr	2302	1	In	in	IN
cord-006860-a3b8hyyr	2302	2	a	a	DT
cord-006860-a3b8hyyr	2302	3	concenWation	concenwation	NN
cord-006860-a3b8hyyr	2302	4	range	range	NN
cord-006860-a3b8hyyr	2302	5	from	from	IN
cord-006860-a3b8hyyr	2302	6	1	1	CD
cord-006860-a3b8hyyr	2302	7	to	to	IN
cord-006860-a3b8hyyr	2302	8	10	10	CD
cord-006860-a3b8hyyr	2302	9	U	u	NN
cord-006860-a3b8hyyr	2302	10	/	/	SYM
cord-006860-a3b8hyyr	2302	11	nil	nil	NN
cord-006860-a3b8hyyr	2302	12	calciparin	calciparin	NNP
cord-006860-a3b8hyyr	2302	13	,	,	,
cord-006860-a3b8hyyr	2302	14	fraxiparin	fraxiparin	NNP
cord-006860-a3b8hyyr	2302	15	,	,	,
cord-006860-a3b8hyyr	2302	16	CY	CY	NNP
cord-006860-a3b8hyyr	2302	17	222	222	CD
cord-006860-a3b8hyyr	2302	18	and	and	CC
cord-006860-a3b8hyyr	2302	19	astenose	astenose	NN
cord-006860-a3b8hyyr	2302	20	led	lead	VBD
cord-006860-a3b8hyyr	2302	21	to	to	IN
cord-006860-a3b8hyyr	2302	22	a	a	DT
cord-006860-a3b8hyyr	2302	23	potentiation	potentiation	NN
cord-006860-a3b8hyyr	2302	24	of	of	IN
cord-006860-a3b8hyyr	2302	25	the	the	DT
cord-006860-a3b8hyyr	2302	26	ADPinduced	adpinduced	JJ
cord-006860-a3b8hyyr	2302	27	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2302	28	whereas	whereas	IN
cord-006860-a3b8hyyr	2302	29	CY	CY	NNP
cord-006860-a3b8hyyr	2302	30	231	231	CD
cord-006860-a3b8hyyr	2302	31	,	,	,
cord-006860-a3b8hyyr	2302	32	hexasaccharide	hexasaccharide	NN
cord-006860-a3b8hyyr	2302	33	and	and	CC
cord-006860-a3b8hyyr	2302	34	SSH	SSH	NNP
cord-006860-a3b8hyyr	2302	35	14	14	CD
cord-006860-a3b8hyyr	2302	36	did	do	VBD
cord-006860-a3b8hyyr	2302	37	not	not	RB
cord-006860-a3b8hyyr	2302	38	show	show	VB
cord-006860-a3b8hyyr	2302	39	this	this	DT
cord-006860-a3b8hyyr	2302	40	effect	effect	NN
cord-006860-a3b8hyyr	2302	41	.	.	.
cord-006860-a3b8hyyr	2303	1	The	the	DT
cord-006860-a3b8hyyr	2303	2	increase	increase	NN
cord-006860-a3b8hyyr	2303	3	in	in	IN
cord-006860-a3b8hyyr	2303	4	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2303	5	was	be	VBD
cord-006860-a3b8hyyr	2303	6	associated	associate	VBN
cord-006860-a3b8hyyr	2303	7	with	with	IN
cord-006860-a3b8hyyr	2303	8	an	an	DT
cord-006860-a3b8hyyr	2303	9	increase	increase	NN
cord-006860-a3b8hyyr	2303	10	in	in	IN
cord-006860-a3b8hyyr	2303	11	thromboxane	thromboxane	NN
cord-006860-a3b8hyyr	2303	12	A2	A2	NNP
cord-006860-a3b8hyyr	2303	13	lbrmation	lbrmation	NN
cord-006860-a3b8hyyr	2303	14	.	.	.
cord-006860-a3b8hyyr	2304	1	In	in	IN
cord-006860-a3b8hyyr	2304	2	addition	addition	NN
cord-006860-a3b8hyyr	2304	3	,	,	,
cord-006860-a3b8hyyr	2304	4	the	the	DT
cord-006860-a3b8hyyr	2304	5	effect	effect	NN
cord-006860-a3b8hyyr	2304	6	of	of	IN
cord-006860-a3b8hyyr	2304	7	calciparin	calciparin	NN
cord-006860-a3b8hyyr	2304	8	,	,	,
cord-006860-a3b8hyyr	2304	9	fraxiparin	fraxiparin	NNP
cord-006860-a3b8hyyr	2304	10	,	,	,
cord-006860-a3b8hyyr	2304	11	CY	CY	NNP
cord-006860-a3b8hyyr	2304	12	222	222	CD
cord-006860-a3b8hyyr	2304	13	and	and	CC
cord-006860-a3b8hyyr	2304	14	astenose	astenose	NN
cord-006860-a3b8hyyr	2304	15	on	on	IN
cord-006860-a3b8hyyr	2304	16	ADP	ADP	NNP
cord-006860-a3b8hyyr	2304	17	-	-	HYPH
cord-006860-a3b8hyyr	2304	18	induced	induce	VBN
cord-006860-a3b8hyyr	2304	19	platelet	platelet	NN
cord-006860-a3b8hyyr	2304	20	activation	activation	NN
cord-006860-a3b8hyyr	2304	21	in	in	IN
cord-006860-a3b8hyyr	2304	22	whole	whole	JJ
cord-006860-a3b8hyyr	2304	23	blood	blood	NN
cord-006860-a3b8hyyr	2304	24	was	be	VBD
cord-006860-a3b8hyyr	2304	25	investigated	investigate	VBN
cord-006860-a3b8hyyr	2304	26	by	by	IN
cord-006860-a3b8hyyr	2304	27	flow	flow	NN
cord-006860-a3b8hyyr	2304	28	cytometric	cytometric	NNP
cord-006860-a3b8hyyr	2304	29	analysis	analysis	NN
cord-006860-a3b8hyyr	2304	30	using	use	VBG
cord-006860-a3b8hyyr	2304	31	monoelonal	monoelonal	JJ
cord-006860-a3b8hyyr	2304	32	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2304	33	to	to	IN
cord-006860-a3b8hyyr	2304	34	platelet	platelet	NN
cord-006860-a3b8hyyr	2304	35	surface	surface	NN
cord-006860-a3b8hyyr	2304	36	receptors	receptor	NNS
cord-006860-a3b8hyyr	2304	37	OPIIIa	OPIIIa	NNS
cord-006860-a3b8hyyr	2304	38	(	(	-LRB-
cord-006860-a3b8hyyr	2304	39	CD-61	CD-61	NNP
cord-006860-a3b8hyyr	2304	40	)	)	-RRB-
cord-006860-a3b8hyyr	2304	41	and	and	CC
cord-006860-a3b8hyyr	2304	42	P	p	NN
cord-006860-a3b8hyyr	2304	43	-	-	HYPH
cord-006860-a3b8hyyr	2304	44	selectin	selectin	NNP
cord-006860-a3b8hyyr	2304	45	(	(	-LRB-
cord-006860-a3b8hyyr	2304	46	CD-62	CD-62	NNP
cord-006860-a3b8hyyr	2304	47	)	)	-RRB-
cord-006860-a3b8hyyr	2304	48	.	.	.
cord-006860-a3b8hyyr	2305	1	At	at	IN
cord-006860-a3b8hyyr	2305	2	concentrations	concentration	NNS
cord-006860-a3b8hyyr	2305	3	that	that	WDT
cord-006860-a3b8hyyr	2305	4	caused	cause	VBD
cord-006860-a3b8hyyr	2305	5	a	a	DT
cord-006860-a3b8hyyr	2305	6	maximum	maximum	JJ
cord-006860-a3b8hyyr	2305	7	potentiation	potentiation	NN
cord-006860-a3b8hyyr	2305	8	of	of	IN
cord-006860-a3b8hyyr	2305	9	ADP	ADP	NNP
cord-006860-a3b8hyyr	2305	10	-	-	HYPH
cord-006860-a3b8hyyr	2305	11	induced	induce	VBN
cord-006860-a3b8hyyr	2305	12	platelet	platelet	NN
cord-006860-a3b8hyyr	2305	13	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2305	14	these	these	DT
cord-006860-a3b8hyyr	2305	15	substances	substance	NNS
cord-006860-a3b8hyyr	2305	16	led	lead	VBD
cord-006860-a3b8hyyr	2305	17	to	to	IN
cord-006860-a3b8hyyr	2305	18	a	a	DT
cord-006860-a3b8hyyr	2305	19	strong	strong	JJ
cord-006860-a3b8hyyr	2305	20	increase	increase	NN
cord-006860-a3b8hyyr	2305	21	of	of	IN
cord-006860-a3b8hyyr	2305	22	ADP	ADP	NNP
cord-006860-a3b8hyyr	2305	23	-	-	HYPH
cord-006860-a3b8hyyr	2305	24	mediated	mediate	VBN
cord-006860-a3b8hyyr	2305	25	activation	activation	NN
cord-006860-a3b8hyyr	2305	26	of	of	IN
cord-006860-a3b8hyyr	2305	27	platelets	platelet	NNS
cord-006860-a3b8hyyr	2305	28	in	in	IN
cord-006860-a3b8hyyr	2305	29	whole	whole	JJ
cord-006860-a3b8hyyr	2305	30	blood	blood	NN
cord-006860-a3b8hyyr	2305	31	.	.	.
cord-006860-a3b8hyyr	2306	1	The	the	DT
cord-006860-a3b8hyyr	2306	2	effect	effect	NN
cord-006860-a3b8hyyr	2306	3	was	be	VBD
cord-006860-a3b8hyyr	2306	4	most	most	RBS
cord-006860-a3b8hyyr	2306	5	pronounced	pronounce	VBN
cord-006860-a3b8hyyr	2306	6	when	when	WRB
cord-006860-a3b8hyyr	2306	7	the	the	DT
cord-006860-a3b8hyyr	2306	8	blood	blood	NN
cord-006860-a3b8hyyr	2306	9	was	be	VBD
cord-006860-a3b8hyyr	2306	10	anticoagulated	anticoagulate	VBN
cord-006860-a3b8hyyr	2306	11	with	with	IN
cord-006860-a3b8hyyr	2306	12	calciparin	calciparin	NNP
cord-006860-a3b8hyyr	2306	13	and	and	CC
cord-006860-a3b8hyyr	2306	14	astenose	astenose	NNP
cord-006860-a3b8hyyr	2306	15	,	,	,
cord-006860-a3b8hyyr	2306	16	resp	resp	NNP
cord-006860-a3b8hyyr	2306	17	.	.	.
cord-006860-a3b8hyyr	2307	1	In	in	IN
cord-006860-a3b8hyyr	2307	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	2307	3	,	,	,
cord-006860-a3b8hyyr	2307	4	the	the	DT
cord-006860-a3b8hyyr	2307	5	results	result	NNS
cord-006860-a3b8hyyr	2307	6	suggest	suggest	VBP
cord-006860-a3b8hyyr	2307	7	that	that	IN
cord-006860-a3b8hyyr	2307	8	the	the	DT
cord-006860-a3b8hyyr	2307	9	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2307	10	-	-	HYPH
cord-006860-a3b8hyyr	2307	11	promoting	promote	VBG
cord-006860-a3b8hyyr	2307	12	effect	effect	NN
cord-006860-a3b8hyyr	2307	13	of	of	IN
cord-006860-a3b8hyyr	2307	14	heparin	heparin	NN
cord-006860-a3b8hyyr	2307	15	derivatives	derivative	NNS
cord-006860-a3b8hyyr	2307	16	included	include	VBN
cord-006860-a3b8hyyr	2307	17	in	in	IN
cord-006860-a3b8hyyr	2307	18	this	this	DT
cord-006860-a3b8hyyr	2307	19	study	study	NN
cord-006860-a3b8hyyr	2307	20	is	be	VBZ
cord-006860-a3b8hyyr	2307	21	dependent	dependent	JJ
cord-006860-a3b8hyyr	2307	22	on	on	IN
cord-006860-a3b8hyyr	2307	23	the	the	DT
cord-006860-a3b8hyyr	2307	24	molecular	molecular	JJ
cord-006860-a3b8hyyr	2307	25	weight	weight	NN
cord-006860-a3b8hyyr	2307	26	and	and	CC
cord-006860-a3b8hyyr	2307	27	the	the	DT
cord-006860-a3b8hyyr	2307	28	degree	degree	NN
cord-006860-a3b8hyyr	2307	29	of	of	IN
cord-006860-a3b8hyyr	2307	30	sulfation	sulfation	NN
cord-006860-a3b8hyyr	2307	31	and	and	CC
cord-006860-a3b8hyyr	2307	32	is	be	VBZ
cord-006860-a3b8hyyr	2307	33	in	in	IN
cord-006860-a3b8hyyr	2307	34	part	part	NN
cord-006860-a3b8hyyr	2307	35	due	due	IN
cord-006860-a3b8hyyr	2307	36	to	to	IN
cord-006860-a3b8hyyr	2307	37	the	the	DT
cord-006860-a3b8hyyr	2307	38	generation	generation	NN
cord-006860-a3b8hyyr	2307	39	of	of	IN
cord-006860-a3b8hyyr	2307	40	thromboxane	thromboxane	NN
cord-006860-a3b8hyyr	2307	41	.	.	.
cord-006860-a3b8hyyr	2308	1	Heparins	heparin	NNS
cord-006860-a3b8hyyr	2308	2	are	be	VBP
cord-006860-a3b8hyyr	2308	3	negatively	negatively	RB
cord-006860-a3b8hyyr	2308	4	charged	charge	VBN
cord-006860-a3b8hyyr	2308	5	polysaccharides	polysaccharide	NNS
cord-006860-a3b8hyyr	2308	6	and	and	CC
cord-006860-a3b8hyyr	2308	7	bind	bind	VB
cord-006860-a3b8hyyr	2308	8	protamine	protamine	NN
cord-006860-a3b8hyyr	2308	9	forming	form	VBG
cord-006860-a3b8hyyr	2308	10	a	a	DT
cord-006860-a3b8hyyr	2308	11	stable	stable	JJ
cord-006860-a3b8hyyr	2308	12	complex	complex	NN
cord-006860-a3b8hyyr	2308	13	.	.	.
cord-006860-a3b8hyyr	2309	1	Here	here	RB
cord-006860-a3b8hyyr	2309	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	2309	3	report	report	VBP
cord-006860-a3b8hyyr	2309	4	on	on	IN
cord-006860-a3b8hyyr	2309	5	the	the	DT
cord-006860-a3b8hyyr	2309	6	properties	property	NNS
cord-006860-a3b8hyyr	2309	7	of	of	IN
cord-006860-a3b8hyyr	2309	8	microbeads	microbead	NNS
cord-006860-a3b8hyyr	2309	9	(	(	-LRB-
cord-006860-a3b8hyyr	2309	10	4.5	4.5	CD
cord-006860-a3b8hyyr	2309	11	pro	pro	JJ
cord-006860-a3b8hyyr	2309	12	)	)	-RRB-
cord-006860-a3b8hyyr	2309	13	coated	coat	VBN
cord-006860-a3b8hyyr	2309	14	by	by	IN
cord-006860-a3b8hyyr	2309	15	protamine	protamine	NNP
cord-006860-a3b8hyyr	2309	16	.	.	.
cord-006860-a3b8hyyr	2310	1	Protamine	Protamine	NNP
cord-006860-a3b8hyyr	2310	2	chloride	chloride	NN
cord-006860-a3b8hyyr	2310	3	(	(	-LRB-
cord-006860-a3b8hyyr	2310	4	0.16	0.16	CD
cord-006860-a3b8hyyr	2310	5	IJM	IJM	NNP
cord-006860-a3b8hyyr	2310	6	)	)	-RRB-
cord-006860-a3b8hyyr	2310	7	was	be	VBD
cord-006860-a3b8hyyr	2310	8	covalently	covalently	RB
cord-006860-a3b8hyyr	2310	9	bound	bind	VBN
cord-006860-a3b8hyyr	2310	10	to	to	IN
cord-006860-a3b8hyyr	2310	11	0.5	0.5	CD
cord-006860-a3b8hyyr	2310	12	mg	mg	NN
cord-006860-a3b8hyyr	2310	13	paramagnetic	paramagnetic	JJ
cord-006860-a3b8hyyr	2310	14	tosyl	tosyl	NN
cord-006860-a3b8hyyr	2310	15	..	..	.
cord-006860-a3b8hyyr	2311	1	activated	activate	VBN
cord-006860-a3b8hyyr	2311	2	microbeads	microbeads	NNP
cord-006860-a3b8hyyr	2311	3	M-450	M-450	NNP
cord-006860-a3b8hyyr	2311	4	(	(	-LRB-
cord-006860-a3b8hyyr	2311	5	Dynal	Dynal	NNP
cord-006860-a3b8hyyr	2311	6	)	)	-RRB-
cord-006860-a3b8hyyr	2311	7	.	.	.
cord-006860-a3b8hyyr	2312	1	The	the	DT
cord-006860-a3b8hyyr	2312	2	covalent	covalent	JJ
cord-006860-a3b8hyyr	2312	3	binding	binding	NN
cord-006860-a3b8hyyr	2312	4	of	of	IN
cord-006860-a3b8hyyr	2312	5	protamine	protamine	NN
cord-006860-a3b8hyyr	2312	6	was	be	VBD
cord-006860-a3b8hyyr	2312	7	from	from	IN
cord-006860-a3b8hyyr	2312	8	1.0	1.0	CD
cord-006860-a3b8hyyr	2312	9	to	to	IN
cord-006860-a3b8hyyr	2312	10	13,0	13,0	CD
cord-006860-a3b8hyyr	2312	11	mg	mg	NNP
cord-006860-a3b8hyyr	2312	12	/	/	SYM
cord-006860-a3b8hyyr	2312	13	g	g	NN
cord-006860-a3b8hyyr	2312	14	beads	bead	NNS
cord-006860-a3b8hyyr	2312	15	.	.	.
cord-006860-a3b8hyyr	2313	1	Protamine	Protamine	NNP
cord-006860-a3b8hyyr	2313	2	-	-	HYPH
cord-006860-a3b8hyyr	2313	3	Dynabeads	Dynabeads	NNP
cord-006860-a3b8hyyr	2313	4	were	be	VBD
cord-006860-a3b8hyyr	2313	5	produced	produce	VBN
cord-006860-a3b8hyyr	2313	6	in	in	IN
cord-006860-a3b8hyyr	2313	7	a	a	DT
cord-006860-a3b8hyyr	2313	8	phosphate	phosphate	NN
cord-006860-a3b8hyyr	2313	9	buffer	buffer	NN
cord-006860-a3b8hyyr	2313	10	at	at	IN
cord-006860-a3b8hyyr	2313	11	different	different	JJ
cord-006860-a3b8hyyr	2313	12	pH	pH	NNP
cord-006860-a3b8hyyr	2313	13	(	(	-LRB-
cord-006860-a3b8hyyr	2313	14	7,0	7,0	CD
cord-006860-a3b8hyyr	2313	15	;	;	:
cord-006860-a3b8hyyr	2313	16	7,5	7,5	CD
cord-006860-a3b8hyyr	2313	17	;	;	:
cord-006860-a3b8hyyr	2313	18	8,0	8,0	CD
cord-006860-a3b8hyyr	2313	19	and	and	CC
cord-006860-a3b8hyyr	2313	20	8,5	8,5	CD
cord-006860-a3b8hyyr	2313	21	)	)	-RRB-
cord-006860-a3b8hyyr	2313	22	.	.	.
cord-006860-a3b8hyyr	2314	1	The	the	DT
cord-006860-a3b8hyyr	2314	2	Protamine	Protamine	NNP
cord-006860-a3b8hyyr	2314	3	-	-	HYPH
cord-006860-a3b8hyyr	2314	4	Dynabeads	Dynabeads	NNP
cord-006860-a3b8hyyr	2314	5	produced	produce	VBD
cord-006860-a3b8hyyr	2314	6	pH	pH	NNP
cord-006860-a3b8hyyr	2314	7	7.5	7.5	CD
cord-006860-a3b8hyyr	2315	1	showed	show	VBD
cord-006860-a3b8hyyr	2315	2	the	the	DT
cord-006860-a3b8hyyr	2315	3	best	good	JJS
cord-006860-a3b8hyyr	2315	4	properties	property	NNS
cord-006860-a3b8hyyr	2315	5	for	for	IN
cord-006860-a3b8hyyr	2315	6	flow	flow	NN
cord-006860-a3b8hyyr	2315	7	cytometry	cytometry	NN
cord-006860-a3b8hyyr	2315	8	analysis	analysis	NN
cord-006860-a3b8hyyr	2315	9	.	.	.
cord-006860-a3b8hyyr	2316	1	In	in	IN
cord-006860-a3b8hyyr	2316	2	saline	saline	NN
cord-006860-a3b8hyyr	2316	3	solution	solution	NN
cord-006860-a3b8hyyr	2316	4	they	-PRON-	PRP
cord-006860-a3b8hyyr	2316	5	bound	bind	VBD
cord-006860-a3b8hyyr	2316	6	LMM	lmm	NN
cord-006860-a3b8hyyr	2316	7	-	-	HYPH
cord-006860-a3b8hyyr	2316	8	heparin	heparin	NN
cord-006860-a3b8hyyr	2316	9	-	-	HYPH
cord-006860-a3b8hyyr	2316	10	tyramine	tyramine	NN
cord-006860-a3b8hyyr	2316	11	-	-	HYPH
cord-006860-a3b8hyyr	2316	12	fitc	fitc	NN
cord-006860-a3b8hyyr	2317	1	(	(	-LRB-
cord-006860-a3b8hyyr	2317	2	LMMH	LMMH	NNP
cord-006860-a3b8hyyr	2317	3	-	-	HYPH
cord-006860-a3b8hyyr	2317	4	Tyr	Tyr	NNP
cord-006860-a3b8hyyr	2317	5	-	-	HYPH
cord-006860-a3b8hyyr	2317	6	Fitc	Fitc	NNP
cord-006860-a3b8hyyr	2317	7	)	)	-RRB-
cord-006860-a3b8hyyr	2317	8	dose	dose	VB
cord-006860-a3b8hyyr	2317	9	dependently	dependently	RB
cord-006860-a3b8hyyr	2317	10	from	from	IN
cord-006860-a3b8hyyr	2317	11	0.001	0.001	CD
cord-006860-a3b8hyyr	2317	12	to	to	IN
cord-006860-a3b8hyyr	2317	13	2	2	CD
cord-006860-a3b8hyyr	2317	14	U	U	NNP
cord-006860-a3b8hyyr	2317	15	/	/	SYM
cord-006860-a3b8hyyr	2317	16	ml	ml	NNS
cord-006860-a3b8hyyr	2317	17	,	,	,
cord-006860-a3b8hyyr	2317	18	whereas	whereas	IN
cord-006860-a3b8hyyr	2317	19	in	in	IN
cord-006860-a3b8hyyr	2317	20	plasma	plasma	NN
cord-006860-a3b8hyyr	2317	21	and	and	CC
cord-006860-a3b8hyyr	2317	22	blood	blood	NN
cord-006860-a3b8hyyr	2317	23	they	-PRON-	PRP
cord-006860-a3b8hyyr	2317	24	bound	bind	VBD
cord-006860-a3b8hyyr	2317	25	LMMH	LMMH	NNP
cord-006860-a3b8hyyr	2317	26	-	-	HYPH
cord-006860-a3b8hyyr	2317	27	Tyr	Tyr	NNP
cord-006860-a3b8hyyr	2317	28	-	-	HYPH
cord-006860-a3b8hyyr	2317	29	Fitc	Fitc	NNP
cord-006860-a3b8hyyr	2317	30	from	from	IN
cord-006860-a3b8hyyr	2317	31	0.05	0.05	CD
cord-006860-a3b8hyyr	2317	32	to	to	IN
cord-006860-a3b8hyyr	2317	33	2	2	CD
cord-006860-a3b8hyyr	2317	34	U	U	NNP
cord-006860-a3b8hyyr	2317	35	/	/	SYM
cord-006860-a3b8hyyr	2317	36	ml	ml	NN
cord-006860-a3b8hyyr	2317	37	.	.	.
cord-006860-a3b8hyyr	2318	1	Dependent	dependent	JJ
cord-006860-a3b8hyyr	2318	2	on	on	IN
cord-006860-a3b8hyyr	2318	3	the	the	DT
cord-006860-a3b8hyyr	2318	4	binding	bind	VBG
cord-006860-a3b8hyyr	2318	5	protocol	protocol	NN
cord-006860-a3b8hyyr	2318	6	,	,	,
cord-006860-a3b8hyyr	2318	7	the	the	DT
cord-006860-a3b8hyyr	2318	8	microbeads	microbead	NNS
cord-006860-a3b8hyyr	2318	9	also	also	RB
cord-006860-a3b8hyyr	2318	10	bind	bind	VBP
cord-006860-a3b8hyyr	2318	11	proteins	protein	NNS
cord-006860-a3b8hyyr	2318	12	unspecifically	unspecifically	RB
cord-006860-a3b8hyyr	2318	13	,	,	,
cord-006860-a3b8hyyr	2318	14	i.e	i.e	FW
cord-006860-a3b8hyyr	2318	15	bovine	bovine	JJ
cord-006860-a3b8hyyr	2318	16	serum	serum	NN
cord-006860-a3b8hyyr	2318	17	albumine	albumine	NN
cord-006860-a3b8hyyr	2318	18	and	and	CC
cord-006860-a3b8hyyr	2318	19	protamine	protamine	VB
cord-006860-a3b8hyyr	2318	20	to	to	IN
cord-006860-a3b8hyyr	2318	21	a	a	DT
cord-006860-a3b8hyyr	2318	22	lower	low	JJR
cord-006860-a3b8hyyr	2318	23	extent	extent	NN
cord-006860-a3b8hyyr	2318	24	.	.	.
cord-006860-a3b8hyyr	2319	1	The	the	DT
cord-006860-a3b8hyyr	2319	2	adsorbed	adsorb	VBN
cord-006860-a3b8hyyr	2319	3	proteins	protein	NNS
cord-006860-a3b8hyyr	2319	4	,	,	,
cord-006860-a3b8hyyr	2319	5	however	however	RB
cord-006860-a3b8hyyr	2319	6	do	do	VBP
cord-006860-a3b8hyyr	2319	7	not	not	RB
cord-006860-a3b8hyyr	2319	8	bind	bind	VB
cord-006860-a3b8hyyr	2319	9	LMMH	LMMH	NNP
cord-006860-a3b8hyyr	2319	10	-	-	HYPH
cord-006860-a3b8hyyr	2319	11	Tyr	Tyr	NNP
cord-006860-a3b8hyyr	2319	12	-	-	HYPH
cord-006860-a3b8hyyr	2319	13	Fitc	Fitc	NNP
cord-006860-a3b8hyyr	2319	14	dose	dose	NN
cord-006860-a3b8hyyr	2319	15	dependently	dependently	RB
cord-006860-a3b8hyyr	2319	16	.	.	.
cord-006860-a3b8hyyr	2320	1	The	the	DT
cord-006860-a3b8hyyr	2320	2	saturation	saturation	NN
cord-006860-a3b8hyyr	2320	3	of	of	IN
cord-006860-a3b8hyyr	2320	4	the	the	DT
cord-006860-a3b8hyyr	2320	5	proteins	protein	NNS
cord-006860-a3b8hyyr	2320	6	on	on	IN
cord-006860-a3b8hyyr	2320	7	the	the	DT
cord-006860-a3b8hyyr	2320	8	beads	bead	NNS
cord-006860-a3b8hyyr	2320	9	was	be	VBD
cord-006860-a3b8hyyr	2320	10	determined	determine	VBN
cord-006860-a3b8hyyr	2320	11	as	as	IN
cord-006860-a3b8hyyr	2320	12	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2320	13	relative	relative	JJ
cord-006860-a3b8hyyr	2320	14	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	2320	15	intensity	intensity	NN
cord-006860-a3b8hyyr	2320	16	(	(	-LRB-
cord-006860-a3b8hyyr	2320	17	rfi	rfi	NNP
cord-006860-a3b8hyyr	2320	18	)	)	-RRB-
cord-006860-a3b8hyyr	2320	19	.	.	.
cord-006860-a3b8hyyr	2321	1	In	in	IN
cord-006860-a3b8hyyr	2321	2	saline	saline	NN
cord-006860-a3b8hyyr	2321	3	solution	solution	NN
cord-006860-a3b8hyyr	2321	4	the	the	DT
cord-006860-a3b8hyyr	2321	5	saturation	saturation	NN
cord-006860-a3b8hyyr	2321	6	was	be	VBD
cord-006860-a3b8hyyr	2321	7	measured	measure	VBN
cord-006860-a3b8hyyr	2321	8	at	at	IN
cord-006860-a3b8hyyr	2321	9	380	380	CD
cord-006860-a3b8hyyr	2321	10	rfi	rfi	NNP
cord-006860-a3b8hyyr	2321	11	,	,	,
cord-006860-a3b8hyyr	2321	12	in	in	IN
cord-006860-a3b8hyyr	2321	13	human	human	JJ
cord-006860-a3b8hyyr	2321	14	plasma	plasma	NN
cord-006860-a3b8hyyr	2321	15	at	at	IN
cord-006860-a3b8hyyr	2321	16	325	325	CD
cord-006860-a3b8hyyr	2321	17	rfi	rfi	NNP
cord-006860-a3b8hyyr	2321	18	and	and	CC
cord-006860-a3b8hyyr	2321	19	in	in	IN
cord-006860-a3b8hyyr	2321	20	whole	whole	JJ
cord-006860-a3b8hyyr	2321	21	blood	blood	NN
cord-006860-a3b8hyyr	2321	22	at	at	IN
cord-006860-a3b8hyyr	2321	23	252	252	CD
cord-006860-a3b8hyyr	2321	24	rfi	rfi	NNP
cord-006860-a3b8hyyr	2321	25	.	.	.
cord-006860-a3b8hyyr	2322	1	Using	use	VBG
cord-006860-a3b8hyyr	2322	2	flow	flow	NN
cord-006860-a3b8hyyr	2322	3	cytometry	cytometry	NN
cord-006860-a3b8hyyr	2322	4	erythrocyctes	erythrocycte	NNS
cord-006860-a3b8hyyr	2322	5	,	,	,
cord-006860-a3b8hyyr	2322	6	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	2322	7	,	,	,
cord-006860-a3b8hyyr	2322	8	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	2322	9	and	and	CC
cord-006860-a3b8hyyr	2322	10	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	2322	11	were	be	VBD
cord-006860-a3b8hyyr	2322	12	not	not	RB
cord-006860-a3b8hyyr	2322	13	bound	bind	VBN
cord-006860-a3b8hyyr	2322	14	to	to	IN
cord-006860-a3b8hyyr	2322	15	Protamine	Protamine	NNP
cord-006860-a3b8hyyr	2322	16	Dynabeads	Dynabeads	NNP
cord-006860-a3b8hyyr	2322	17	.	.	.
cord-006860-a3b8hyyr	2323	1	These	these	DT
cord-006860-a3b8hyyr	2323	2	data	datum	NNS
cord-006860-a3b8hyyr	2323	3	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	2323	4	that	that	IN
cord-006860-a3b8hyyr	2323	5	Protamine	Protamine	NNP
cord-006860-a3b8hyyr	2323	6	-	-	HYPH
cord-006860-a3b8hyyr	2323	7	Dynabeads	Dynabeads	NNP
cord-006860-a3b8hyyr	2323	8	can	can	MD
cord-006860-a3b8hyyr	2323	9	be	be	VB
cord-006860-a3b8hyyr	2323	10	used	use	VBN
cord-006860-a3b8hyyr	2323	11	to	to	TO
cord-006860-a3b8hyyr	2323	12	measure	measure	VB
cord-006860-a3b8hyyr	2323	13	the	the	DT
cord-006860-a3b8hyyr	2323	14	concentration	concentration	NN
cord-006860-a3b8hyyr	2323	15	of	of	IN
cord-006860-a3b8hyyr	2323	16	LMMH	LMMH	NNP
cord-006860-a3b8hyyr	2323	17	-	-	HYPH
cord-006860-a3b8hyyr	2323	18	Tyr	Tyr	NNP
cord-006860-a3b8hyyr	2323	19	-	-	HYPH
cord-006860-a3b8hyyr	2323	20	Fitc	Fitc	NNP
cord-006860-a3b8hyyr	2323	21	in	in	IN
cord-006860-a3b8hyyr	2323	22	saline	saline	NN
cord-006860-a3b8hyyr	2323	23	solution	solution	NN
cord-006860-a3b8hyyr	2323	24	,	,	,
cord-006860-a3b8hyyr	2323	25	plasma	plasma	NN
cord-006860-a3b8hyyr	2323	26	and	and	CC
cord-006860-a3b8hyyr	2323	27	blood	blood	NN
cord-006860-a3b8hyyr	2323	28	because	because	IN
cord-006860-a3b8hyyr	2323	29	they	-PRON-	PRP
cord-006860-a3b8hyyr	2323	30	do	do	VBP
cord-006860-a3b8hyyr	2323	31	not	not	RB
cord-006860-a3b8hyyr	2323	32	bind	bind	VB
cord-006860-a3b8hyyr	2323	33	to	to	IN
cord-006860-a3b8hyyr	2323	34	human	human	JJ
cord-006860-a3b8hyyr	2323	35	blood	blood	NN
cord-006860-a3b8hyyr	2323	36	cells	cell	NNS
cord-006860-a3b8hyyr	2323	37	.	.	.
cord-006860-a3b8hyyr	2324	1	The	the	DT
cord-006860-a3b8hyyr	2324	2	present	present	JJ
cord-006860-a3b8hyyr	2324	3	study	study	NN
cord-006860-a3b8hyyr	2324	4	was	be	VBD
cord-006860-a3b8hyyr	2324	5	designed	design	VBN
cord-006860-a3b8hyyr	2324	6	to	to	TO
cord-006860-a3b8hyyr	2324	7	investigate	investigate	VB
cord-006860-a3b8hyyr	2324	8	the	the	DT
cord-006860-a3b8hyyr	2324	9	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	2324	10	action	action	NN
cord-006860-a3b8hyyr	2324	11	of	of	IN
cord-006860-a3b8hyyr	2324	12	inhaled	inhale	VBN
cord-006860-a3b8hyyr	2324	13	low	low	JJ
cord-006860-a3b8hyyr	2324	14	molecular	molecular	JJ
cord-006860-a3b8hyyr	2324	15	weight	weight	NN
cord-006860-a3b8hyyr	2324	16	(	(	-LRB-
cord-006860-a3b8hyyr	2324	17	LMW)-heparin	LMW)-heparin	NNP
cord-006860-a3b8hyyr	2324	18	in	in	IN
cord-006860-a3b8hyyr	2324	19	healthy	healthy	JJ
cord-006860-a3b8hyyr	2324	20	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	2324	21	.	.	.
cord-006860-a3b8hyyr	2325	1	3,000	3,000	CD
cord-006860-a3b8hyyr	2325	2	IU	IU	NNP
cord-006860-a3b8hyyr	2325	3	(	(	-LRB-
cord-006860-a3b8hyyr	2325	4	group	group	NN
cord-006860-a3b8hyyr	2325	5	t	t	NNP
cord-006860-a3b8hyyr	2325	6	)	)	-RRB-
cord-006860-a3b8hyyr	2325	7	,	,	,
cord-006860-a3b8hyyr	2325	8	9,000	9,000	CD
cord-006860-a3b8hyyr	2325	9	IU	IU	NNP
cord-006860-a3b8hyyr	2325	10	(	(	-LRB-
cord-006860-a3b8hyyr	2325	11	group	group	NN
cord-006860-a3b8hyyr	2325	12	2	2	CD
cord-006860-a3b8hyyr	2325	13	)	)	-RRB-
cord-006860-a3b8hyyr	2325	14	,	,	,
cord-006860-a3b8hyyr	2325	15	27,000	27,000	CD
cord-006860-a3b8hyyr	2325	16	IU	IU	NNP
cord-006860-a3b8hyyr	2325	17	(	(	-LRB-
cord-006860-a3b8hyyr	2325	18	group	group	NN
cord-006860-a3b8hyyr	2325	19	3	3	CD
cord-006860-a3b8hyyr	2325	20	)	)	-RRB-
cord-006860-a3b8hyyr	2325	21	or	or	CC
cord-006860-a3b8hyyr	2325	22	54,000	54,000	CD
cord-006860-a3b8hyyr	2325	23	IU	IU	NNP
cord-006860-a3b8hyyr	2325	24	(	(	-LRB-
cord-006860-a3b8hyyr	2325	25	group	group	NN
cord-006860-a3b8hyyr	2325	26	4	4	CD
cord-006860-a3b8hyyr	2325	27	)	)	-RRB-
cord-006860-a3b8hyyr	2325	28	LMW	lmw	NN
cord-006860-a3b8hyyr	2325	29	-	-	HYPH
cord-006860-a3b8hyyr	2325	30	heparin	heparin	NN
cord-006860-a3b8hyyr	2325	31	were	be	VBD
cord-006860-a3b8hyyr	2325	32	given	give	VBN
cord-006860-a3b8hyyr	2325	33	to	to	IN
cord-006860-a3b8hyyr	2325	34	20	20	CD
cord-006860-a3b8hyyr	2325	35	healthy	healthy	JJ
cord-006860-a3b8hyyr	2325	36	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	2325	37	each	each	DT
cord-006860-a3b8hyyr	2325	38	at	at	IN
cord-006860-a3b8hyyr	2325	39	4	4	CD
cord-006860-a3b8hyyr	2325	40	weeks	week	NNS
cord-006860-a3b8hyyr	2325	41	intervals	interval	NNS
cord-006860-a3b8hyyr	2325	42	.	.	.
cord-006860-a3b8hyyr	2326	1	In	in	IN
cord-006860-a3b8hyyr	2326	2	group	group	NN
cord-006860-a3b8hyyr	2326	3	1	1	CD
cord-006860-a3b8hyyr	2326	4	tissue	tissue	NN
cord-006860-a3b8hyyr	2326	5	iactor	iactor	NN
cord-006860-a3b8hyyr	2326	6	pathway	pathway	NN
cord-006860-a3b8hyyr	2326	7	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2326	8	(	(	-LRB-
cord-006860-a3b8hyyr	2326	9	TFPI	TFPI	NNP
cord-006860-a3b8hyyr	2326	10	)	)	-RRB-
cord-006860-a3b8hyyr	2326	11	antigen	antigen	NN
cord-006860-a3b8hyyr	2326	12	and	and	CC
cord-006860-a3b8hyyr	2326	13	activity	activity	NN
cord-006860-a3b8hyyr	2326	14	,	,	,
cord-006860-a3b8hyyr	2326	15	82222	82222	CD
cord-006860-a3b8hyyr	2326	16	chromogenic	chromogenic	NNP
cord-006860-a3b8hyyr	2326	17	factor	factor	NN
cord-006860-a3b8hyyr	2326	18	Xa	Xa	NNP
cord-006860-a3b8hyyr	2326	19	assay	assay	NN
cord-006860-a3b8hyyr	2326	20	,	,	,
cord-006860-a3b8hyyr	2326	21	heptest	heptest	NNP
cord-006860-a3b8hyyr	2326	22	,	,	,
cord-006860-a3b8hyyr	2326	23	APTT	APTT	NNP
cord-006860-a3b8hyyr	2326	24	and	and	CC
cord-006860-a3b8hyyr	2326	25	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	2326	26	clotting	clotting	NN
cord-006860-a3b8hyyr	2326	27	time	time	NN
cord-006860-a3b8hyyr	2326	28	(	(	-LRB-
cord-006860-a3b8hyyr	2326	29	TOT	TOT	NNP
cord-006860-a3b8hyyr	2326	30	)	)	-RRB-
cord-006860-a3b8hyyr	2326	31	remained	remain	VBD
cord-006860-a3b8hyyr	2326	32	unchanged	unchanged	JJ
cord-006860-a3b8hyyr	2326	33	during	during	IN
cord-006860-a3b8hyyr	2326	34	the	the	DT
cord-006860-a3b8hyyr	2326	35	10	10	CD
cord-006860-a3b8hyyr	2326	36	days	day	NNS
cord-006860-a3b8hyyr	2326	37	observation	observation	NN
cord-006860-a3b8hyyr	2326	38	period	period	NN
cord-006860-a3b8hyyr	2326	39	.	.	.
cord-006860-a3b8hyyr	2327	1	In	in	IN
cord-006860-a3b8hyyr	2327	2	group	group	NN
cord-006860-a3b8hyyr	2327	3	2	2	CD
cord-006860-a3b8hyyr	2327	4	TFPI	tfpi	NN
cord-006860-a3b8hyyr	2327	5	antigen	antigen	NN
cord-006860-a3b8hyyr	2327	6	and	and	CC
cord-006860-a3b8hyyr	2327	7	activity	activity	NN
cord-006860-a3b8hyyr	2327	8	,	,	,
cord-006860-a3b8hyyr	2327	9	APTT	APTT	NNP
cord-006860-a3b8hyyr	2327	10	,	,	,
cord-006860-a3b8hyyr	2327	11	TCT	TCT	NNP
cord-006860-a3b8hyyr	2327	12	and	and	CC
cord-006860-a3b8hyyr	2327	13	the	the	DT
cord-006860-a3b8hyyr	2327	14	$	$	$
cord-006860-a3b8hyyr	2327	15	2222	2222	CD
cord-006860-a3b8hyyr	2327	16	method	method	NN
cord-006860-a3b8hyyr	2327	17	remained	remain	VBD
cord-006860-a3b8hyyr	2327	18	uneffected	uneffected	JJ
cord-006860-a3b8hyyr	2327	19	.	.	.
cord-006860-a3b8hyyr	2328	1	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2328	2	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2328	3	times	time	NNS
cord-006860-a3b8hyyr	2328	4	were	be	VBD
cord-006860-a3b8hyyr	2328	5	18.7	18.7	CD
cord-006860-a3b8hyyr	2328	6	+	+	SYM
cord-006860-a3b8hyyr	2328	7	2.0	2.0	CD
cord-006860-a3b8hyyr	2328	8	before	before	RB
cord-006860-a3b8hyyr	2328	9	,	,	,
cord-006860-a3b8hyyr	2328	10	26.1	26.1	CD
cord-006860-a3b8hyyr	2328	11	+	+	SYM
cord-006860-a3b8hyyr	2328	12	5.2	5.2	CD
cord-006860-a3b8hyyr	2328	13	sec	sec	NNS
cord-006860-a3b8hyyr	2328	14	.	.	.
cord-006860-a3b8hyyr	2329	1	6	6	CD
cord-006860-a3b8hyyr	2329	2	hrs	hrs	NN
cord-006860-a3b8hyyr	2329	3	and	and	CC
cord-006860-a3b8hyyr	2329	4	to	to	IN
cord-006860-a3b8hyyr	2329	5	20.5	20.5	CD
cord-006860-a3b8hyyr	2329	6	+	+	SYM
cord-006860-a3b8hyyr	2329	7	1.9	1.9	CD
cord-006860-a3b8hyyr	2329	8	sec	sec	NNS
cord-006860-a3b8hyyr	2329	9	.	.	.
cord-006860-a3b8hyyr	2330	1	24	24	CD
cord-006860-a3b8hyyr	2330	2	hrs	hrs	NN
cord-006860-a3b8hyyr	2330	3	after	after	IN
cord-006860-a3b8hyyr	2330	4	inhalation	inhalation	NN
cord-006860-a3b8hyyr	2330	5	.	.	.
cord-006860-a3b8hyyr	2331	1	In	in	IN
cord-006860-a3b8hyyr	2331	2	group	group	NN
cord-006860-a3b8hyyr	2331	3	3	3	CD
cord-006860-a3b8hyyr	2331	4	TFPI	tfpi	NN
cord-006860-a3b8hyyr	2331	5	antigen	antigen	NN
cord-006860-a3b8hyyr	2331	6	increased	increase	VBD
cord-006860-a3b8hyyr	2331	7	from	from	IN
cord-006860-a3b8hyyr	2331	8	74.1	74.1	CD
cord-006860-a3b8hyyr	2331	9	+	+	SYM
cord-006860-a3b8hyyr	2331	10	13.9	13.9	CD
cord-006860-a3b8hyyr	2331	11	to	to	IN
cord-006860-a3b8hyyr	2331	12	80.5	80.5	CD
cord-006860-a3b8hyyr	2331	13	+	+	SYM
cord-006860-a3b8hyyr	2331	14	14.2	14.2	CD
cord-006860-a3b8hyyr	2331	15	ng	ng	NN
cord-006860-a3b8hyyr	2331	16	/	/	SYM
cord-006860-a3b8hyyr	2331	17	ml	ml	NN
cord-006860-a3b8hyyr	2331	18	3	3	CD
cord-006860-a3b8hyyr	2331	19	hrs	hrs	NN
cord-006860-a3b8hyyr	2331	20	after	after	IN
cord-006860-a3b8hyyr	2331	21	inhalation	inhalation	NN
cord-006860-a3b8hyyr	2331	22	.	.	.
cord-006860-a3b8hyyr	2332	1	TFPI	tfpi	NN
cord-006860-a3b8hyyr	2332	2	activity	activity	NN
cord-006860-a3b8hyyr	2332	3	remained	remain	VBD
cord-006860-a3b8hyyr	2332	4	unchanged	unchanged	JJ
cord-006860-a3b8hyyr	2332	5	.	.	.
cord-006860-a3b8hyyr	2333	1	$	$	$
cord-006860-a3b8hyyr	2333	2	2222	2222	CD
cord-006860-a3b8hyyr	2333	3	method	method	NN
cord-006860-a3b8hyyr	2333	4	increased	increase	VBN
cord-006860-a3b8hyyr	2333	5	from	from	IN
cord-006860-a3b8hyyr	2333	6	0.01	0.01	CD
cord-006860-a3b8hyyr	2333	7	to	to	IN
cord-006860-a3b8hyyr	2333	8	0.08	0.08	CD
cord-006860-a3b8hyyr	2333	9	+	+	CD
cord-006860-a3b8hyyr	2333	10	0.06	0.06	CD
cord-006860-a3b8hyyr	2333	11	IU	IU	NNP
cord-006860-a3b8hyyr	2333	12	/	/	SYM
cord-006860-a3b8hyyr	2333	13	ml	ml	NN
cord-006860-a3b8hyyr	2333	14	6	6	CD
cord-006860-a3b8hyyr	2333	15	hrs	hrs	NN
cord-006860-a3b8hyyr	2333	16	after	after	IN
cord-006860-a3b8hyyr	2333	17	inhalation	inhalation	NN
cord-006860-a3b8hyyr	2333	18	.	.	.
cord-006860-a3b8hyyr	2334	1	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2334	2	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2334	3	values	value	NNS
cord-006860-a3b8hyyr	2334	4	were	be	VBD
cord-006860-a3b8hyyr	2334	5	prolonged	prolong	VBN
cord-006860-a3b8hyyr	2334	6	up	up	IN
cord-006860-a3b8hyyr	2334	7	to	to	IN
cord-006860-a3b8hyyr	2334	8	42	42	CD
cord-006860-a3b8hyyr	2334	9	_	_	NN
cord-006860-a3b8hyyr	2334	10	+	+	SYM
cord-006860-a3b8hyyr	2334	11	7.6	7.6	CD
cord-006860-a3b8hyyr	2334	12	s	s	NN
cord-006860-a3b8hyyr	2334	13	ec	ec	NNP
cord-006860-a3b8hyyr	2334	14	after	after	IN
cord-006860-a3b8hyyr	2334	15	6	6	CD
cord-006860-a3b8hyyr	2334	16	hrs	hrs	NN
cord-006860-a3b8hyyr	2334	17	and	and	CC
cord-006860-a3b8hyyr	2334	18	returned	return	VBD
cord-006860-a3b8hyyr	2334	19	to	to	IN
cord-006860-a3b8hyyr	2334	20	normal	normal	JJ
cord-006860-a3b8hyyr	2334	21	within	within	IN
cord-006860-a3b8hyyr	2334	22	72	72	CD
cord-006860-a3b8hyyr	2334	23	hrs	hrs	NN
cord-006860-a3b8hyyr	2334	24	after	after	IN
cord-006860-a3b8hyyr	2334	25	inhalation	inhalation	NN
cord-006860-a3b8hyyr	2334	26	.	.	.
cord-006860-a3b8hyyr	2335	1	APTT	APTT	NNP
cord-006860-a3b8hyyr	2335	2	and	and	CC
cord-006860-a3b8hyyr	2335	3	TCT	TCT	NNP
cord-006860-a3b8hyyr	2335	4	remained	remain	VBD
cord-006860-a3b8hyyr	2335	5	unchanged	unchanged	JJ
cord-006860-a3b8hyyr	2335	6	.	.	.
cord-006860-a3b8hyyr	2336	1	After	after	IN
cord-006860-a3b8hyyr	2336	2	inhalation	inhalation	NN
cord-006860-a3b8hyyr	2336	3	of	of	IN
cord-006860-a3b8hyyr	2336	4	54,000	54,000	CD
cord-006860-a3b8hyyr	2336	5	IU	IU	NNP
cord-006860-a3b8hyyr	2336	6	LMW	lmw	NN
cord-006860-a3b8hyyr	2336	7	-	-	HYPH
cord-006860-a3b8hyyr	2336	8	heparin	heparin	NN
cord-006860-a3b8hyyr	2336	9	,	,	,
cord-006860-a3b8hyyr	2336	10	the	the	DT
cord-006860-a3b8hyyr	2336	11	following	follow	VBG
cord-006860-a3b8hyyr	2336	12	changes	change	NNS
cord-006860-a3b8hyyr	2336	13	were	be	VBD
cord-006860-a3b8hyyr	2336	14	observed	observe	VBN
cord-006860-a3b8hyyr	2336	15	:	:	:
cord-006860-a3b8hyyr	2336	16	TFPI	TFPI	NNP
cord-006860-a3b8hyyr	2336	17	antigen	antigen	NN
cord-006860-a3b8hyyr	2336	18	increased	increase	VBD
cord-006860-a3b8hyyr	2336	19	to	to	IN
cord-006860-a3b8hyyr	2336	20	103	103	CD
cord-006860-a3b8hyyr	2337	1	+	+	CC
cord-006860-a3b8hyyr	2338	1	_	_	NNP
cord-006860-a3b8hyyr	2338	2	.	.	.
cord-006860-a3b8hyyr	2339	1	17.9	17.9	CD
cord-006860-a3b8hyyr	2339	2	ng	ng	NNP
cord-006860-a3b8hyyr	2339	3	/	/	SYM
cord-006860-a3b8hyyr	2339	4	ml	ml	NN
cord-006860-a3b8hyyr	2339	5	and	and	CC
cord-006860-a3b8hyyr	2339	6	normalized	normalize	VBD
cord-006860-a3b8hyyr	2339	7	within	within	IN
cord-006860-a3b8hyyr	2339	8	24	24	CD
cord-006860-a3b8hyyr	2339	9	hrs	hrs	NN
cord-006860-a3b8hyyr	2339	10	.	.	.
cord-006860-a3b8hyyr	2340	1	-I'FPI	-I'FPI	.
cord-006860-a3b8hyyr	2341	1	activity	activity	NN
cord-006860-a3b8hyyr	2341	2	increased	increase	VBD
cord-006860-a3b8hyyr	2341	3	to	to	IN
cord-006860-a3b8hyyr	2341	4	1.14	1.14	CD
cord-006860-a3b8hyyr	2341	5	_	_	NN
cord-006860-a3b8hyyr	2342	1	+	+	SYM
cord-006860-a3b8hyyr	2342	2	0.23	0.23	CD
cord-006860-a3b8hyyr	2342	3	U	u	NN
cord-006860-a3b8hyyr	2342	4	3	3	CD
cord-006860-a3b8hyyr	2342	5	hrs	hrs	NN
cord-006860-a3b8hyyr	2342	6	after	after	IN
cord-006860-a3b8hyyr	2342	7	inhalation	inhalation	NN
cord-006860-a3b8hyyr	2342	8	and	and	CC
cord-006860-a3b8hyyr	2342	9	was	be	VBD
cord-006860-a3b8hyyr	2342	10	normal	normal	JJ
cord-006860-a3b8hyyr	2342	11	after	after	IN
cord-006860-a3b8hyyr	2342	12	24	24	CD
cord-006860-a3b8hyyr	2342	13	hrs	hrs	NN
cord-006860-a3b8hyyr	2342	14	.	.	.
cord-006860-a3b8hyyr	2343	1	Antifactor	Antifactor	NNP
cord-006860-a3b8hyyr	2343	2	Xa	Xa	NNP
cord-006860-a3b8hyyr	2343	3	activity	activity	NN
cord-006860-a3b8hyyr	2343	4	,	,	,
cord-006860-a3b8hyyr	2343	5	as	as	IN
cord-006860-a3b8hyyr	2343	6	measured	measure	VBN
cord-006860-a3b8hyyr	2343	7	by	by	IN
cord-006860-a3b8hyyr	2343	8	S2222	S2222	NNP
cord-006860-a3b8hyyr	2343	9	method	method	NN
cord-006860-a3b8hyyr	2343	10	,	,	,
cord-006860-a3b8hyyr	2343	11	increased	increase	VBD
cord-006860-a3b8hyyr	2343	12	to	to	IN
cord-006860-a3b8hyyr	2343	13	0.343	0.343	CD
cord-006860-a3b8hyyr	2343	14	+	+	CC
cord-006860-a3b8hyyr	2344	1	0.196	0.196	NFP
cord-006860-a3b8hyyr	2344	2	U	U	NNP
cord-006860-a3b8hyyr	2344	3	/	/	SYM
cord-006860-a3b8hyyr	2344	4	ml	ml	XX
cord-006860-a3b8hyyr	2344	5	after	after	IN
cord-006860-a3b8hyyr	2344	6	6	6	CD
cord-006860-a3b8hyyr	2344	7	hrs	hrs	NN
cord-006860-a3b8hyyr	2344	8	and	and	CC
cord-006860-a3b8hyyr	2344	9	was	be	VBD
cord-006860-a3b8hyyr	2344	10	normal	normal	JJ
cord-006860-a3b8hyyr	2344	11	after	after	IN
cord-006860-a3b8hyyr	2344	12	72	72	CD
cord-006860-a3b8hyyr	2344	13	hrs	hrs	NN
cord-006860-a3b8hyyr	2344	14	.	.	.
cord-006860-a3b8hyyr	2345	1	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2345	2	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2345	3	values	value	NNS
cord-006860-a3b8hyyr	2345	4	increased	increase	VBD
cord-006860-a3b8hyyr	2345	5	to	to	IN
cord-006860-a3b8hyyr	2345	6	77.5	77.5	CD
cord-006860-a3b8hyyr	2345	7	+	+	SYM
cord-006860-a3b8hyyr	2345	8	11.8	11.8	CD
cord-006860-a3b8hyyr	2345	9	sec	sec	NNP
cord-006860-a3b8hyyr	2345	10	6	6	CD
cord-006860-a3b8hyyr	2345	11	hrs	hrs	NN
cord-006860-a3b8hyyr	2345	12	after	after	IN
cord-006860-a3b8hyyr	2345	13	inhalation	inhalation	NN
cord-006860-a3b8hyyr	2345	14	and	and	CC
cord-006860-a3b8hyyr	2345	15	normalized	normalize	VBD
cord-006860-a3b8hyyr	2345	16	after	after	IN
cord-006860-a3b8hyyr	2345	17	144	144	CD
cord-006860-a3b8hyyr	2345	18	hrs	hrs	NN
cord-006860-a3b8hyyr	2345	19	.	.	.
cord-006860-a3b8hyyr	2346	1	APTT	APTT	NNP
cord-006860-a3b8hyyr	2346	2	and	and	CC
cord-006860-a3b8hyyr	2346	3	TCT	TCT	NNP
cord-006860-a3b8hyyr	2346	4	did	do	VBD
cord-006860-a3b8hyyr	2346	5	not	not	RB
cord-006860-a3b8hyyr	2346	6	change	change	VB
cord-006860-a3b8hyyr	2346	7	throughout	throughout	IN
cord-006860-a3b8hyyr	2346	8	the	the	DT
cord-006860-a3b8hyyr	2346	9	observation	observation	NN
cord-006860-a3b8hyyr	2346	10	period	period	NN
cord-006860-a3b8hyyr	2346	11	.	.	.
cord-006860-a3b8hyyr	2347	1	The	the	DT
cord-006860-a3b8hyyr	2347	2	data	datum	NNS
cord-006860-a3b8hyyr	2347	3	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	2347	4	a	a	DT
cord-006860-a3b8hyyr	2347	5	resorption	resorption	NN
cord-006860-a3b8hyyr	2347	6	of	of	IN
cord-006860-a3b8hyyr	2347	7	LMW	lmw	NN
cord-006860-a3b8hyyr	2347	8	-	-	HYPH
cord-006860-a3b8hyyr	2347	9	heparin	heparin	VBN
cord-006860-a3b8hyyr	2347	10	by	by	IN
cord-006860-a3b8hyyr	2347	11	intrapulmonary	intrapulmonary	JJ
cord-006860-a3b8hyyr	2347	12	route	route	NN
cord-006860-a3b8hyyr	2347	13	in	in	IN
cord-006860-a3b8hyyr	2347	14	man	man	NN
cord-006860-a3b8hyyr	2347	15	.	.	.
cord-006860-a3b8hyyr	2348	1	No	no	DT
cord-006860-a3b8hyyr	2348	2	side	side	NN
cord-006860-a3b8hyyr	2348	3	effects	effect	NNS
cord-006860-a3b8hyyr	2348	4	were	be	VBD
cord-006860-a3b8hyyr	2348	5	observed	observe	VBN
cord-006860-a3b8hyyr	2348	6	.	.	.
cord-006860-a3b8hyyr	2349	1	Recently	recently	RB
cord-006860-a3b8hyyr	2349	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	2349	3	developed	develop	VBD
cord-006860-a3b8hyyr	2349	4	a	a	DT
cord-006860-a3b8hyyr	2349	5	tritium	tritium	NN
cord-006860-a3b8hyyr	2349	6	-	-	HYPH
cord-006860-a3b8hyyr	2349	7	labelled	label	VBN
cord-006860-a3b8hyyr	2349	8	arachidonic	arachidonic	JJ
cord-006860-a3b8hyyr	2349	9	acid	acid	NN
cord-006860-a3b8hyyr	2349	10	(	(	-LRB-
cord-006860-a3b8hyyr	2349	11	[	[	-LRB-
cord-006860-a3b8hyyr	2349	12	3H]AA	3h]aa	LS
cord-006860-a3b8hyyr	2349	13	)	)	-RRB-
cord-006860-a3b8hyyr	2349	14	release	release	NN
cord-006860-a3b8hyyr	2349	15	test	test	NN
cord-006860-a3b8hyyr	2349	16	with	with	IN
cord-006860-a3b8hyyr	2349	17	high	high	JJ
cord-006860-a3b8hyyr	2349	18	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	2349	19	to	to	IN
cord-006860-a3b8hyyr	2349	20	membrane	membrane	NN
cord-006860-a3b8hyyr	2349	21	-	-	HYPH
cord-006860-a3b8hyyr	2349	22	toxic	toxic	JJ
cord-006860-a3b8hyyr	2349	23	agents	agent	NNS
cord-006860-a3b8hyyr	2349	24	.	.	.
cord-006860-a3b8hyyr	2350	1	The	the	DT
cord-006860-a3b8hyyr	2350	2	assay	assay	NN
cord-006860-a3b8hyyr	2350	3	performed	perform	VBN
cord-006860-a3b8hyyr	2350	4	in	in	IN
cord-006860-a3b8hyyr	2350	5	U937	U937	NNP
cord-006860-a3b8hyyr	2350	6	cells	cell	NNS
cord-006860-a3b8hyyr	2350	7	is	be	VBZ
cord-006860-a3b8hyyr	2350	8	intended	intend	VBN
cord-006860-a3b8hyyr	2350	9	to	to	TO
cord-006860-a3b8hyyr	2350	10	evaluate	evaluate	VB
cord-006860-a3b8hyyr	2350	11	ehemicals	ehemical	NNS
cord-006860-a3b8hyyr	2350	12	,	,	,
cord-006860-a3b8hyyr	2350	13	drugs	drug	NNS
cord-006860-a3b8hyyr	2350	14	and	and	CC
cord-006860-a3b8hyyr	2350	15	biomatefials	biomatefial	NNS
cord-006860-a3b8hyyr	2350	16	with	with	IN
cord-006860-a3b8hyyr	2350	17	regard	regard	NN
cord-006860-a3b8hyyr	2350	18	to	to	IN
cord-006860-a3b8hyyr	2350	19	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2350	20	eytomembrane	eytomembrane	NN
cord-006860-a3b8hyyr	2350	21	toxicity	toxicity	NN
cord-006860-a3b8hyyr	2350	22	[	[	-LRB-
cord-006860-a3b8hyyr	2350	23	KlOeking	KlOeking	NNP
cord-006860-a3b8hyyr	2350	24	et	et	XX
cord-006860-a3b8hyyr	2350	25	at	at	IN
cord-006860-a3b8hyyr	2350	26	.	.	.
cord-006860-a3b8hyyr	2351	1	(	(	-LRB-
cord-006860-a3b8hyyr	2351	2	1994	1994	CD
cord-006860-a3b8hyyr	2351	3	)	)	-RRB-
cord-006860-a3b8hyyr	2351	4	,	,	,
cord-006860-a3b8hyyr	2351	5	Toxicology	Toxicology	NNP
cord-006860-a3b8hyyr	2351	6	in	in	IN
cord-006860-a3b8hyyr	2351	7	vitro	vitro	NNP
cord-006860-a3b8hyyr	2351	8	8	8	CD
cord-006860-a3b8hyyr	2351	9	,	,	,
cord-006860-a3b8hyyr	2351	10	775	775	CD
cord-006860-a3b8hyyr	2351	11	-	-	SYM
cord-006860-a3b8hyyr	2351	12	777	777	CD
cord-006860-a3b8hyyr	2351	13	]	]	-RRB-
cord-006860-a3b8hyyr	2351	14	.	.	.
cord-006860-a3b8hyyr	2352	1	Local	local	JJ
cord-006860-a3b8hyyr	2352	2	irritation	irritation	NN
cord-006860-a3b8hyyr	2352	3	reactions	reaction	NNS
cord-006860-a3b8hyyr	2352	4	are	be	VBP
cord-006860-a3b8hyyr	2352	5	described	describe	VBN
cord-006860-a3b8hyyr	2352	6	in	in	IN
cord-006860-a3b8hyyr	2352	7	patients	patient	NNS
cord-006860-a3b8hyyr	2352	8	receiving	receive	VBG
cord-006860-a3b8hyyr	2352	9	therapeurieat	therapeurieat	JJ
cord-006860-a3b8hyyr	2352	10	dosages	dosage	NNS
cord-006860-a3b8hyyr	2352	11	of	of	IN
cord-006860-a3b8hyyr	2352	12	LMW	LMW	NNP
cord-006860-a3b8hyyr	2352	13	heparin	heparin	JJ
cord-006860-a3b8hyyr	2352	14	.	.	.
cord-006860-a3b8hyyr	2353	1	This	this	DT
cord-006860-a3b8hyyr	2353	2	fact	fact	NN
cord-006860-a3b8hyyr	2353	3	prompted	prompt	VBD
cord-006860-a3b8hyyr	2353	4	us	-PRON-	PRP
cord-006860-a3b8hyyr	2353	5	to	to	TO
cord-006860-a3b8hyyr	2353	6	examine	examine	VB
cord-006860-a3b8hyyr	2353	7	the	the	DT
cord-006860-a3b8hyyr	2353	8	following	follow	VBG
cord-006860-a3b8hyyr	2353	9	LMW	LMW	NNP
cord-006860-a3b8hyyr	2353	10	hepafins	hepafin	NNS
cord-006860-a3b8hyyr	2353	11	and	and	CC
cord-006860-a3b8hyyr	2353	12	heparinoids	heparinoid	NNS
cord-006860-a3b8hyyr	2353	13	for	for	IN
cord-006860-a3b8hyyr	2353	14	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2353	15	membrane	membrane	NN
cord-006860-a3b8hyyr	2353	16	toxicity	toxicity	NN
cord-006860-a3b8hyyr	2353	17	in	in	IN
cord-006860-a3b8hyyr	2353	18	U937	U937	NNP
cord-006860-a3b8hyyr	2353	19	cells	cell	NNS
cord-006860-a3b8hyyr	2353	20	:	:	:
cord-006860-a3b8hyyr	2353	21	reviparin	reviparin	NN
cord-006860-a3b8hyyr	2353	22	-	-	HYPH
cord-006860-a3b8hyyr	2353	23	sodium	sodium	NN
cord-006860-a3b8hyyr	2353	24	,	,	,
cord-006860-a3b8hyyr	2353	25	enoxaparine	enoxaparine	JJ
cord-006860-a3b8hyyr	2353	26	-	-	HYPH
cord-006860-a3b8hyyr	2353	27	sodium	sodium	NN
cord-006860-a3b8hyyr	2353	28	,	,	,
cord-006860-a3b8hyyr	2353	29	mueopolysccharide	mueopolysccharide	NNP
cord-006860-a3b8hyyr	2353	30	polysulphate	polysulphate	NNP
cord-006860-a3b8hyyr	2353	31	(	(	-LRB-
cord-006860-a3b8hyyr	2353	32	MPS	MPS	NNP
cord-006860-a3b8hyyr	2353	33	)	)	-RRB-
cord-006860-a3b8hyyr	2353	34	,	,	,
cord-006860-a3b8hyyr	2353	35	pentosan	pentosan	NNP
cord-006860-a3b8hyyr	2353	36	polysulfate	polysulfate	NNP
cord-006860-a3b8hyyr	2353	37	sodium	sodium	NNP
cord-006860-a3b8hyyr	2353	38	(	(	-LRB-
cord-006860-a3b8hyyr	2353	39	PPS	PPS	NNP
cord-006860-a3b8hyyr	2353	40	)	)	-RRB-
cord-006860-a3b8hyyr	2353	41	,	,	,
cord-006860-a3b8hyyr	2353	42	polysulfated	polysulfate	VBN
cord-006860-a3b8hyyr	2353	43	bis	bis	NNP
cord-006860-a3b8hyyr	2353	44	-	-	HYPH
cord-006860-a3b8hyyr	2353	45	lactobionic	lactobionic	JJ
cord-006860-a3b8hyyr	2353	46	acid	acid	NN
cord-006860-a3b8hyyr	2353	47	amide	amide	NN
cord-006860-a3b8hyyr	2353	48	derivatives	derivative	NNS
cord-006860-a3b8hyyr	2353	49	LW10082	lw10082	NN
cord-006860-a3b8hyyr	2353	50	(	(	-LRB-
cord-006860-a3b8hyyr	2353	51	aprosulate	aprosulate	NNP
cord-006860-a3b8hyyr	2353	52	)	)	-RRB-
cord-006860-a3b8hyyr	2353	53	and	and	CC
cord-006860-a3b8hyyr	2353	54	LW10086	LW10086	NNP
cord-006860-a3b8hyyr	2353	55	.	.	.
cord-006860-a3b8hyyr	2354	1	For	for	IN
cord-006860-a3b8hyyr	2354	2	this	this	DT
cord-006860-a3b8hyyr	2354	3	purpose	purpose	NN
cord-006860-a3b8hyyr	2354	4	,	,	,
cord-006860-a3b8hyyr	2354	5	[	[	-LRB-
cord-006860-a3b8hyyr	2354	6	31	31	CD
cord-006860-a3b8hyyr	2354	7	-	-	HYPH
cord-006860-a3b8hyyr	2354	8	-1]AA	-1]AA	NNP
cord-006860-a3b8hyyr	2354	9	labelled	label	VBN
cord-006860-a3b8hyyr	2354	10	U937	U937	NNP
cord-006860-a3b8hyyr	2354	11	ceils	ceil	NNS
cord-006860-a3b8hyyr	2354	12	were	be	VBD
cord-006860-a3b8hyyr	2354	13	incubated	incubate	VBN
cord-006860-a3b8hyyr	2354	14	with	with	IN
cord-006860-a3b8hyyr	2354	15	different	different	JJ
cord-006860-a3b8hyyr	2354	16	concentrations	concentration	NNS
cord-006860-a3b8hyyr	2354	17	of	of	IN
cord-006860-a3b8hyyr	2354	18	LMW	LMW	NNP
cord-006860-a3b8hyyr	2354	19	heparins	heparin	NNS
cord-006860-a3b8hyyr	2354	20	and	and	CC
cord-006860-a3b8hyyr	2354	21	heparinoids	heparinoid	NNS
cord-006860-a3b8hyyr	2354	22	at	at	IN
cord-006860-a3b8hyyr	2354	23	37	37	CD
cord-006860-a3b8hyyr	2354	24	°	°	NN
cord-006860-a3b8hyyr	2354	25	C	c	NN
cord-006860-a3b8hyyr	2354	26	for	for	IN
cord-006860-a3b8hyyr	2354	27	1	1	CD
cord-006860-a3b8hyyr	2354	28	hour	hour	NN
cord-006860-a3b8hyyr	2354	29	.	.	.
cord-006860-a3b8hyyr	2355	1	Compared	compare	VBN
cord-006860-a3b8hyyr	2355	2	with	with	IN
cord-006860-a3b8hyyr	2355	3	untreated	untreated	JJ
cord-006860-a3b8hyyr	2355	4	cells	cell	NNS
cord-006860-a3b8hyyr	2355	5	,	,	,
cord-006860-a3b8hyyr	2355	6	the	the	DT
cord-006860-a3b8hyyr	2355	7	[	[	-LRB-
cord-006860-a3b8hyyr	2355	8	~H]AA	~h]aa	NN
cord-006860-a3b8hyyr	2355	9	release	release	NN
cord-006860-a3b8hyyr	2355	10	of	of	IN
cord-006860-a3b8hyyr	2355	11	cells	cell	NNS
cord-006860-a3b8hyyr	2355	12	treated	treat	VBN
cord-006860-a3b8hyyr	2355	13	with	with	IN
cord-006860-a3b8hyyr	2355	14	5	5	CD
cord-006860-a3b8hyyr	2355	15	mg	mg	NN
cord-006860-a3b8hyyr	2355	16	of	of	IN
cord-006860-a3b8hyyr	2355	17	the	the	DT
cord-006860-a3b8hyyr	2355	18	drugs	drug	NNS
cord-006860-a3b8hyyr	2355	19	was	be	VBD
cord-006860-a3b8hyyr	2355	20	two	two	CD
cord-006860-a3b8hyyr	2355	21	times	time	NNS
cord-006860-a3b8hyyr	2355	22	higher	high	JJR
cord-006860-a3b8hyyr	2355	23	with	with	IN
cord-006860-a3b8hyyr	2355	24	reviparin	reviparin	NNP
cord-006860-a3b8hyyr	2355	25	sodium	sodium	NN
cord-006860-a3b8hyyr	2355	26	,	,	,
cord-006860-a3b8hyyr	2355	27	three	three	CD
cord-006860-a3b8hyyr	2355	28	rimes	rimes	NNPS
cord-006860-a3b8hyyr	2355	29	higher	higher	RBR
cord-006860-a3b8hyyr	2355	30	with	with	IN
cord-006860-a3b8hyyr	2355	31	bis	bis	NNP
cord-006860-a3b8hyyr	2355	32	-	-	JJ
cord-006860-a3b8hyyr	2355	33	lactobionic	lactobionic	JJ
cord-006860-a3b8hyyr	2355	34	acid	acid	NN
cord-006860-a3b8hyyr	2355	35	amide	amide	NN
cord-006860-a3b8hyyr	2355	36	LW10086	LW10086	NNP
cord-006860-a3b8hyyr	2355	37	,	,	,
cord-006860-a3b8hyyr	2355	38	five	five	CD
cord-006860-a3b8hyyr	2355	39	times	time	NNS
cord-006860-a3b8hyyr	2355	40	higher	high	JJR
cord-006860-a3b8hyyr	2355	41	with	with	IN
cord-006860-a3b8hyyr	2355	42	pentosan	pentosan	NNP
cord-006860-a3b8hyyr	2355	43	polysulfate	polysulfate	NNP
cord-006860-a3b8hyyr	2355	44	,	,	,
cord-006860-a3b8hyyr	2355	45	20	20	CD
cord-006860-a3b8hyyr	2355	46	times	time	NNS
cord-006860-a3b8hyyr	2355	47	higher	high	JJR
cord-006860-a3b8hyyr	2355	48	with	with	IN
cord-006860-a3b8hyyr	2355	49	ertoxaparine	ertoxaparine	JJ
cord-006860-a3b8hyyr	2355	50	-	-	HYPH
cord-006860-a3b8hyyr	2355	51	sodlum	sodlum	NNP
cord-006860-a3b8hyyr	2355	52	,	,	,
cord-006860-a3b8hyyr	2355	53	but	but	CC
cord-006860-a3b8hyyr	2355	54	it	-PRON-	PRP
cord-006860-a3b8hyyr	2355	55	was	be	VBD
cord-006860-a3b8hyyr	2355	56	equal	equal	JJ
cord-006860-a3b8hyyr	2355	57	to	to	IN
cord-006860-a3b8hyyr	2355	58	the	the	DT
cord-006860-a3b8hyyr	2355	59	control	control	NN
cord-006860-a3b8hyyr	2355	60	with	with	IN
cord-006860-a3b8hyyr	2355	61	mucopolysaccharide	mucopolysaccharide	NNP
cord-006860-a3b8hyyr	2355	62	polysulphate	polysulphate	NNP
cord-006860-a3b8hyyr	2355	63	.	.	.
cord-006860-a3b8hyyr	2356	1	The	the	DT
cord-006860-a3b8hyyr	2356	2	rate	rate	NN
cord-006860-a3b8hyyr	2356	3	of	of	IN
cord-006860-a3b8hyyr	2356	4	araehidonic	araehidonic	NNP
cord-006860-a3b8hyyr	2356	5	acid	acid	NN
cord-006860-a3b8hyyr	2356	6	release	release	NN
cord-006860-a3b8hyyr	2356	7	in	in	IN
cord-006860-a3b8hyyr	2356	8	response	response	NN
cord-006860-a3b8hyyr	2356	9	to	to	IN
cord-006860-a3b8hyyr	2356	10	a	a	DT
cord-006860-a3b8hyyr	2356	11	test	test	NN
cord-006860-a3b8hyyr	2356	12	chemical	chemical	NN
cord-006860-a3b8hyyr	2356	13	may	may	MD
cord-006860-a3b8hyyr	2356	14	therefore	therefore	RB
cord-006860-a3b8hyyr	2356	15	be	be	VB
cord-006860-a3b8hyyr	2356	16	used	use	VBN
cord-006860-a3b8hyyr	2356	17	to	to	TO
cord-006860-a3b8hyyr	2356	18	assess	assess	VB
cord-006860-a3b8hyyr	2356	19	the	the	DT
cord-006860-a3b8hyyr	2356	20	membrane	membrane	NN
cord-006860-a3b8hyyr	2356	21	-	-	HYPH
cord-006860-a3b8hyyr	2356	22	toxic	toxic	JJ
cord-006860-a3b8hyyr	2356	23	effect	effect	NN
cord-006860-a3b8hyyr	2356	24	of	of	IN
cord-006860-a3b8hyyr	2356	25	this	this	DT
cord-006860-a3b8hyyr	2356	26	substance	substance	NN
cord-006860-a3b8hyyr	2356	27	and	and	CC
cord-006860-a3b8hyyr	2356	28	to	to	TO
cord-006860-a3b8hyyr	2356	29	predict	predict	VB
cord-006860-a3b8hyyr	2356	30	its	-PRON-	PRP$
cord-006860-a3b8hyyr	2356	31	the	the	DT
cord-006860-a3b8hyyr	2356	32	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	2356	33	potential	potential	NN
cord-006860-a3b8hyyr	2356	34	in	in	IN
cord-006860-a3b8hyyr	2356	35	the	the	DT
cord-006860-a3b8hyyr	2356	36	skin	skin	NN
cord-006860-a3b8hyyr	2356	37	.	.	.
cord-006860-a3b8hyyr	2357	1	Semi	semi	JJ
cord-006860-a3b8hyyr	2357	2	-	-	JJ
cord-006860-a3b8hyyr	2357	3	synthetic	synthetic	JJ
cord-006860-a3b8hyyr	2357	4	glyensaminoglycans	glyensaminoglycan	NNS
cord-006860-a3b8hyyr	2357	5	(	(	-LRB-
cord-006860-a3b8hyyr	2357	6	GAGs	GAGs	NNP
cord-006860-a3b8hyyr	2357	7	)	)	-RRB-
cord-006860-a3b8hyyr	2357	8	with	with	IN
cord-006860-a3b8hyyr	2357	9	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	2357	10	properties	property	NNS
cord-006860-a3b8hyyr	2357	11	can	can	MD
cord-006860-a3b8hyyr	2357	12	be	be	VB
cord-006860-a3b8hyyr	2357	13	prepared	prepare	VBN
cord-006860-a3b8hyyr	2357	14	from	from	IN
cord-006860-a3b8hyyr	2357	15	the	the	DT
cord-006860-a3b8hyyr	2357	16	E.	E.	NNP
cord-006860-a3b8hyyr	2357	17	Coli	Coli	NNP
cord-006860-a3b8hyyr	2357	18	K5	K5	NNP
cord-006860-a3b8hyyr	2357	19	polysaecharide	polysaecharide	RB
cord-006860-a3b8hyyr	2357	20	by	by	IN
cord-006860-a3b8hyyr	2357	21	coupled	coupled	JJ
cord-006860-a3b8hyyr	2357	22	chemical	chemical	NN
cord-006860-a3b8hyyr	2357	23	and	and	CC
cord-006860-a3b8hyyr	2357	24	enzymatic	enzymatic	JJ
cord-006860-a3b8hyyr	2357	25	methods	method	NNS
cord-006860-a3b8hyyr	2357	26	.	.	.
cord-006860-a3b8hyyr	2358	1	The	the	DT
cord-006860-a3b8hyyr	2358	2	molecular	molecular	JJ
cord-006860-a3b8hyyr	2358	3	weight	weight	NN
cord-006860-a3b8hyyr	2358	4	of	of	IN
cord-006860-a3b8hyyr	2358	5	these	these	DT
cord-006860-a3b8hyyr	2358	6	semi	semi	JJ
cord-006860-a3b8hyyr	2358	7	-	-	JJ
cord-006860-a3b8hyyr	2358	8	synthetic	synthetic	JJ
cord-006860-a3b8hyyr	2358	9	GAGs	gag	NNS
cord-006860-a3b8hyyr	2358	10	can	can	MD
cord-006860-a3b8hyyr	2358	11	be	be	VB
cord-006860-a3b8hyyr	2358	12	adjusted	adjust	VBN
cord-006860-a3b8hyyr	2358	13	to	to	TO
cord-006860-a3b8hyyr	2358	14	obtain	obtain	VB
cord-006860-a3b8hyyr	2358	15	products	product	NNS
cord-006860-a3b8hyyr	2358	16	mimicking	mimic	VBG
cord-006860-a3b8hyyr	2358	17	the	the	DT
cord-006860-a3b8hyyr	2358	18	molecular	molecular	JJ
cord-006860-a3b8hyyr	2358	19	profile	profile	NN
cord-006860-a3b8hyyr	2358	20	of	of	IN
cord-006860-a3b8hyyr	2358	21	a	a	DT
cord-006860-a3b8hyyr	2358	22	low	low	JJ
cord-006860-a3b8hyyr	2358	23	molecular	molecular	JJ
cord-006860-a3b8hyyr	2358	24	weight	weight	NN
cord-006860-a3b8hyyr	2358	25	hepatm	hepatm	NNP
cord-006860-a3b8hyyr	2358	26	.	.	.
cord-006860-a3b8hyyr	2359	1	In	in	IN
cord-006860-a3b8hyyr	2359	2	order	order	NN
cord-006860-a3b8hyyr	2359	3	to	to	TO
cord-006860-a3b8hyyr	2359	4	compare	compare	VB
cord-006860-a3b8hyyr	2359	5	the	the	DT
cord-006860-a3b8hyyr	2359	6	biochemical	biochemical	JJ
cord-006860-a3b8hyyr	2359	7	and	and	CC
cord-006860-a3b8hyyr	2359	8	pharmacologic	pharmacologic	JJ
cord-006860-a3b8hyyr	2359	9	properties	property	NNS
cord-006860-a3b8hyyr	2359	10	of	of	IN
cord-006860-a3b8hyyr	2359	11	a	a	DT
cord-006860-a3b8hyyr	2359	12	semi	semi	JJ
cord-006860-a3b8hyyr	2359	13	-	-	JJ
cord-006860-a3b8hyyr	2359	14	synthetic	synthetic	JJ
cord-006860-a3b8hyyr	2359	15	GAG	gag	NN
cord-006860-a3b8hyyr	2359	16	(	(	-LRB-
cord-006860-a3b8hyyr	2359	17	SR	SR	NNP
cord-006860-a3b8hyyr	2359	18	80486A	80486A	NNP
cord-006860-a3b8hyyr	2359	19	,	,	,
cord-006860-a3b8hyyr	2359	20	Sanofi	Sanofi	NNP
cord-006860-a3b8hyyr	2359	21	/	/	SYM
cord-006860-a3b8hyyr	2359	22	Choay	Choay	NNP
cord-006860-a3b8hyyr	2359	23	)	)	-RRB-
cord-006860-a3b8hyyr	2359	24	with	with	IN
cord-006860-a3b8hyyr	2359	25	a	a	DT
cord-006860-a3b8hyyr	2359	26	commereiany	commereiany	NN
cord-006860-a3b8hyyr	2359	27	available	available	JJ
cord-006860-a3b8hyyr	2359	28	low	low	JJ
cord-006860-a3b8hyyr	2359	29	molecular	molecular	JJ
cord-006860-a3b8hyyr	2359	30	weight	weight	NN
cord-006860-a3b8hyyr	2359	31	heparin	heparin	NN
cord-006860-a3b8hyyr	2359	32	,	,	,
cord-006860-a3b8hyyr	2359	33	Fraxiparine	Fraxiparine	NNP
cord-006860-a3b8hyyr	2359	34	(	(	-LRB-
cord-006860-a3b8hyyr	2359	35	Sanofi	Sanofi	NNP
cord-006860-a3b8hyyr	2359	36	,	,	,
cord-006860-a3b8hyyr	2359	37	Paris	Paris	NNP
cord-006860-a3b8hyyr	2359	38	,	,	,
cord-006860-a3b8hyyr	2359	39	France	France	NNP
cord-006860-a3b8hyyr	2359	40	)	)	-RRB-
cord-006860-a3b8hyyr	2359	41	,	,	,
cord-006860-a3b8hyyr	2359	42	valid	valid	JJ
cord-006860-a3b8hyyr	2359	43	biooheanical	biooheanical	JJ
cord-006860-a3b8hyyr	2359	44	and	and	CC
cord-006860-a3b8hyyr	2359	45	pharmacologic	pharmacologic	JJ
cord-006860-a3b8hyyr	2359	46	methods	method	NNS
cord-006860-a3b8hyyr	2359	47	were	be	VBD
cord-006860-a3b8hyyr	2359	48	used	use	VBN
cord-006860-a3b8hyyr	2359	49	.	.	.
cord-006860-a3b8hyyr	2360	1	The	the	DT
cord-006860-a3b8hyyr	2360	2	molecular	molecular	JJ
cord-006860-a3b8hyyr	2360	3	profile	profile	NN
cord-006860-a3b8hyyr	2360	4	of	of	IN
cord-006860-a3b8hyyr	2360	5	this	this	DT
cord-006860-a3b8hyyr	2360	6	agent	agent	NN
cord-006860-a3b8hyyr	2360	7	as	as	IN
cord-006860-a3b8hyyr	2360	8	determined	determine	VBN
cord-006860-a3b8hyyr	2360	9	by	by	IN
cord-006860-a3b8hyyr	2360	10	HPLC	HPLC	NNP
cord-006860-a3b8hyyr	2360	11	exhibited	exhibit	VBD
cord-006860-a3b8hyyr	2360	12	a	a	DT
cord-006860-a3b8hyyr	2360	13	comparable	comparable	JJ
cord-006860-a3b8hyyr	2360	14	distribution	distribution	NN
cord-006860-a3b8hyyr	2360	15	profile	profile	NN
cord-006860-a3b8hyyr	2360	16	(	(	-LRB-
cord-006860-a3b8hyyr	2360	17	Mr=5.7	Mr=5.7	NNP
cord-006860-a3b8hyyr	2360	18	kDa	kDa	NNPS
cord-006860-a3b8hyyr	2360	19	)	)	-RRB-
cord-006860-a3b8hyyr	2360	20	in	in	IN
cord-006860-a3b8hyyr	2360	21	comparison	comparison	NN
cord-006860-a3b8hyyr	2360	22	to	to	IN
cord-006860-a3b8hyyr	2360	23	Fraxiparine	Fraxiparine	NNP
cord-006860-a3b8hyyr	2360	24	(	(	-LRB-
cord-006860-a3b8hyyr	2360	25	Ma=5.1	Ma=5.1	NNP
cord-006860-a3b8hyyr	2360	26	kDa	kDa	NNP
cord-006860-a3b8hyyr	2360	27	)	)	-RRB-
cord-006860-a3b8hyyr	2360	28	.	.	.
cord-006860-a3b8hyyr	2361	1	The	the	DT
cord-006860-a3b8hyyr	2361	2	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	2361	3	properties	property	NNS
cord-006860-a3b8hyyr	2361	4	of	of	IN
cord-006860-a3b8hyyr	2361	5	SR	SR	NNP
cord-006860-a3b8hyyr	2361	6	80486A	80486a	CD
cord-006860-a3b8hyyr	2361	7	were	be	VBD
cord-006860-a3b8hyyr	2361	8	comparable	comparable	JJ
cord-006860-a3b8hyyr	2361	9	to	to	IN
cord-006860-a3b8hyyr	2361	10	Fraxiparine	Fraxiparine	NNP
cord-006860-a3b8hyyr	2361	11	in	in	IN
cord-006860-a3b8hyyr	2361	12	the	the	DT
cord-006860-a3b8hyyr	2361	13	APTT	APTT	NNP
cord-006860-a3b8hyyr	2361	14	and	and	CC
cord-006860-a3b8hyyr	2361	15	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2361	16	.	.	.
cord-006860-a3b8hyyr	2362	1	However	however	RB
cord-006860-a3b8hyyr	2362	2	,	,	,
cord-006860-a3b8hyyr	2362	3	in	in	IN
cord-006860-a3b8hyyr	2362	4	the	the	DT
cord-006860-a3b8hyyr	2362	5	USP	USP	NNP
cord-006860-a3b8hyyr	2362	6	assay	assay	NN
cord-006860-a3b8hyyr	2362	7	,	,	,
cord-006860-a3b8hyyr	2362	8	this	this	DT
cord-006860-a3b8hyyr	2362	9	agent	agent	NN
cord-006860-a3b8hyyr	2362	10	showed	show	VBD
cord-006860-a3b8hyyr	2362	11	slightly	slightly	RB
cord-006860-a3b8hyyr	2362	12	weaker	weak	JJR
cord-006860-a3b8hyyr	2362	13	activity	activity	NN
cord-006860-a3b8hyyr	2362	14	.	.	.
cord-006860-a3b8hyyr	2363	1	SR	SR	NNP
cord-006860-a3b8hyyr	2363	2	80486A	80486A	NNP
cord-006860-a3b8hyyr	2363	3	also	also	RB
cord-006860-a3b8hyyr	2363	4	exhibi	exhibi	NNP
cord-006860-a3b8hyyr	2363	5	~	~	NFP
cord-006860-a3b8hyyr	2363	6	d	d	XX
cord-006860-a3b8hyyr	2363	7	comparable	comparable	JJ
cord-006860-a3b8hyyr	2363	8	affinity	affinity	NN
cord-006860-a3b8hyyr	2363	9	to	to	IN
cord-006860-a3b8hyyr	2363	10	ATffl	ATffl	NNP
cord-006860-a3b8hyyr	2363	11	and	and	CC
cord-006860-a3b8hyyr	2363	12	HCII	HCII	NNP
cord-006860-a3b8hyyr	2363	13	.	.	.
cord-006860-a3b8hyyr	2364	1	In	in	IN
cord-006860-a3b8hyyr	2364	2	comparison	comparison	NN
cord-006860-a3b8hyyr	2364	3	to	to	IN
cord-006860-a3b8hyyr	2364	4	Fraxiparine	Fraxiparine	NNP
cord-006860-a3b8hyyr	2364	5	,	,	,
cord-006860-a3b8hyyr	2364	6	it	-PRON-	PRP
cord-006860-a3b8hyyr	2364	7	produced	produce	VBD
cord-006860-a3b8hyyr	2364	8	a	a	DT
cord-006860-a3b8hyyr	2364	9	much	much	RB
cord-006860-a3b8hyyr	2364	10	weaker	weak	JJR
cord-006860-a3b8hyyr	2364	11	response	response	NN
cord-006860-a3b8hyyr	2364	12	In	in	IN
cord-006860-a3b8hyyr	2364	13	the	the	DT
cord-006860-a3b8hyyr	2364	14	HIT	hit	NN
cord-006860-a3b8hyyr	2364	15	screening	screening	NN
cord-006860-a3b8hyyr	2364	16	system	system	NN
cord-006860-a3b8hyyr	2364	17	.	.	.
cord-006860-a3b8hyyr	2365	1	In~	In~	NNP
cord-006860-a3b8hyyr	2365	2	viv0	viv0	NN
cord-006860-a3b8hyyr	2365	3	studies	study	NNS
cord-006860-a3b8hyyr	2365	4	,	,	,
cord-006860-a3b8hyyr	2365	5	SR	SR	NNP
cord-006860-a3b8hyyr	2365	6	80486A	80486A	NNP
cord-006860-a3b8hyyr	2365	7	preduecd	preduecd	NN
cord-006860-a3b8hyyr	2365	8	strong	strong	JJ
cord-006860-a3b8hyyr	2365	9	dose	dose	NN
cord-006860-a3b8hyyr	2365	10	-	-	HYPH
cord-006860-a3b8hyyr	2365	11	dependent	dependent	JJ
cord-006860-a3b8hyyr	2365	12	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	2365	13	actions	action	NNS
cord-006860-a3b8hyyr	2365	14	in	in	IN
cord-006860-a3b8hyyr	2365	15	both	both	CC
cord-006860-a3b8hyyr	2365	16	the	the	DT
cord-006860-a3b8hyyr	2365	17	IV	IV	NNP
cord-006860-a3b8hyyr	2365	18	and	and	CC
cord-006860-a3b8hyyr	2365	19	SC	SC	NNP
cord-006860-a3b8hyyr	2365	20	studies	study	NNS
cord-006860-a3b8hyyr	2365	21	in	in	IN
cord-006860-a3b8hyyr	2365	22	the	the	DT
cord-006860-a3b8hyyr	2365	23	rabbit	rabbit	NN
cord-006860-a3b8hyyr	2365	24	jugular	jugular	NN
cord-006860-a3b8hyyr	2365	25	vein	vein	NN
cord-006860-a3b8hyyr	2365	26	stasis	stasis	NN
cord-006860-a3b8hyyr	2365	27	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2365	28	model	model	NN
cord-006860-a3b8hyyr	2365	29	(	(	-LRB-
cord-006860-a3b8hyyr	2365	30	ED50	ED50	NNP
cord-006860-a3b8hyyr	2365	31	=	=	SYM
cord-006860-a3b8hyyr	2365	32	I	i	NN
cord-006860-a3b8hyyr	2365	33	5	5	CD
cord-006860-a3b8hyyr	2365	34	-	-	SYM
cord-006860-a3b8hyyr	2365	35	60	60	CD
cord-006860-a3b8hyyr	2365	36	gg	gg	NNP
cord-006860-a3b8hyyr	2365	37	/	/	SYM
cord-006860-a3b8hyyr	2365	38	kg	kg	NNP
cord-006860-a3b8hyyr	2365	39	)	)	-RRB-
cord-006860-a3b8hyyr	2365	40	.	.	.
cord-006860-a3b8hyyr	2366	1	Additionally	additionally	RB
cord-006860-a3b8hyyr	2366	2	,	,	,
cord-006860-a3b8hyyr	2366	3	it	-PRON-	PRP
cord-006860-a3b8hyyr	2366	4	also	also	RB
cord-006860-a3b8hyyr	2366	5	produced	produce	VBD
cord-006860-a3b8hyyr	2366	6	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	2366	7	aefiorts	aefiort	NNS
cord-006860-a3b8hyyr	2366	8	in	in	IN
cord-006860-a3b8hyyr	2366	9	a	a	DT
cord-006860-a3b8hyyr	2366	10	rat	rat	NN
cord-006860-a3b8hyyr	2366	11	jugular	jugular	NN
cord-006860-a3b8hyyr	2366	12	vein	vein	NN
cord-006860-a3b8hyyr	2366	13	clamping	clamping	NN
cord-006860-a3b8hyyr	2366	14	model	model	NN
cord-006860-a3b8hyyr	2366	15	.	.	.
cord-006860-a3b8hyyr	2367	1	The	the	DT
cord-006860-a3b8hyyr	2367	2	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	2367	3	effects	effect	NNS
cord-006860-a3b8hyyr	2367	4	of	of	IN
cord-006860-a3b8hyyr	2367	5	this	this	DT
cord-006860-a3b8hyyr	2367	6	agent	agent	NN
cord-006860-a3b8hyyr	2367	7	were	be	VBD
cord-006860-a3b8hyyr	2367	8	comparable	comparable	JJ
cord-006860-a3b8hyyr	2367	9	to	to	IN
cord-006860-a3b8hyyr	2367	10	those	those	DT
cord-006860-a3b8hyyr	2367	11	of	of	IN
cord-006860-a3b8hyyr	2367	12	Fraxipafine	Fraxipafine	NNP
cord-006860-a3b8hyyr	2367	13	as	as	IN
cord-006860-a3b8hyyr	2367	14	measured	measure	VBN
cord-006860-a3b8hyyr	2367	15	in	in	IN
cord-006860-a3b8hyyr	2367	16	a	a	DT
cord-006860-a3b8hyyr	2367	17	rabbit	rabbit	NN
cord-006860-a3b8hyyr	2367	18	ear	ear	NN
cord-006860-a3b8hyyr	2367	19	blood	blood	NN
cord-006860-a3b8hyyr	2367	20	loss	loss	NN
cord-006860-a3b8hyyr	2367	21	model	model	NN
cord-006860-a3b8hyyr	2367	22	.	.	.
cord-006860-a3b8hyyr	2368	1	Intravenous	intravenous	JJ
cord-006860-a3b8hyyr	2368	2	administration	administration	NN
cord-006860-a3b8hyyr	2368	3	of	of	IN
cord-006860-a3b8hyyr	2368	4	SR	SR	NNP
cord-006860-a3b8hyyr	2368	5	80486A	80486A	NNP
cord-006860-a3b8hyyr	2368	6	also	also	RB
cord-006860-a3b8hyyr	2368	7	revealed	reveal	VBD
cord-006860-a3b8hyyr	2368	8	a	a	DT
cord-006860-a3b8hyyr	2368	9	comparable	comparable	JJ
cord-006860-a3b8hyyr	2368	10	pharmaeokinetie	pharmaeokinetie	NN
cord-006860-a3b8hyyr	2368	11	behavior	behavior	NN
cord-006860-a3b8hyyr	2368	12	to	to	IN
cord-006860-a3b8hyyr	2368	13	Fraxiparine	Fraxiparine	NNP
cord-006860-a3b8hyyr	2368	14	.	.	.
cord-006860-a3b8hyyr	2369	1	No	no	DT
cord-006860-a3b8hyyr	2369	2	abnomaiitias	abnomaiitias	NN
cord-006860-a3b8hyyr	2369	3	of	of	IN
cord-006860-a3b8hyyr	2369	4	the	the	DT
cord-006860-a3b8hyyr	2369	5	clinical	clinical	JJ
cord-006860-a3b8hyyr	2369	6	chemistry	chemistry	NN
cord-006860-a3b8hyyr	2369	7	(	(	-LRB-
cord-006860-a3b8hyyr	2369	8	change	change	NN
cord-006860-a3b8hyyr	2369	9	in	in	IN
cord-006860-a3b8hyyr	2369	10	liver	liver	NN
cord-006860-a3b8hyyr	2369	11	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	2369	12	)	)	-RRB-
cord-006860-a3b8hyyr	2369	13	and	and	CC
cord-006860-a3b8hyyr	2369	14	hematology	hematology	NN
cord-006860-a3b8hyyr	2369	15	profile	profile	NN
cord-006860-a3b8hyyr	2369	16	(	(	-LRB-
cord-006860-a3b8hyyr	2369	17	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2369	18	and	and	CC
cord-006860-a3b8hyyr	2369	19	lencecytosis	lencecytosis	NN
cord-006860-a3b8hyyr	2369	20	,	,	,
cord-006860-a3b8hyyr	2369	21	etc	etc	FW
cord-006860-a3b8hyyr	2369	22	.	.	.
cord-006860-a3b8hyyr	2369	23	)	)	-RRB-
cord-006860-a3b8hyyr	2369	24	were	be	VBD
cord-006860-a3b8hyyr	2369	25	noted	note	VBN
cord-006860-a3b8hyyr	2369	26	In	in	IN
cord-006860-a3b8hyyr	2369	27	primates	primate	NNS
cord-006860-a3b8hyyr	2369	28	.	.	.
cord-006860-a3b8hyyr	2370	1	At	at	IN
cord-006860-a3b8hyyr	2370	2	a	a	DT
cord-006860-a3b8hyyr	2370	3	dosage	dosage	NN
cord-006860-a3b8hyyr	2370	4	of	of	IN
cord-006860-a3b8hyyr	2370	5	I	-PRON-	PRP
cord-006860-a3b8hyyr	2370	6	and	and	CC
cord-006860-a3b8hyyr	2370	7	2.5	2.5	CD
cord-006860-a3b8hyyr	2370	8	mg	mg	NNP
cord-006860-a3b8hyyr	2370	9	/	/	SYM
cord-006860-a3b8hyyr	2370	10	kg	kg	NNP
cord-006860-a3b8hyyr	2370	11	IV	IV	NNP
cord-006860-a3b8hyyr	2370	12	,	,	,
cord-006860-a3b8hyyr	2370	13	this	this	DT
cord-006860-a3b8hyyr	2370	14	agent	agent	NN
cord-006860-a3b8hyyr	2370	15	also	also	RB
cord-006860-a3b8hyyr	2370	16	caused	cause	VBD
cord-006860-a3b8hyyr	2370	17	a	a	DT
cord-006860-a3b8hyyr	2370	18	release	release	NN
cord-006860-a3b8hyyr	2370	19	of	of	IN
cord-006860-a3b8hyyr	2370	20	functional	functional	JJ
cord-006860-a3b8hyyr	2370	21	TFPI	TFPI	NNP
cord-006860-a3b8hyyr	2370	22	which	which	WDT
cord-006860-a3b8hyyr	2370	23	was	be	VBD
cord-006860-a3b8hyyr	2370	24	comparable	comparable	JJ
cord-006860-a3b8hyyr	2370	25	to	to	IN
cord-006860-a3b8hyyr	2370	26	the	the	DT
cord-006860-a3b8hyyr	2370	27	observed	observed	JJ
cord-006860-a3b8hyyr	2370	28	responses	response	NNS
cord-006860-a3b8hyyr	2370	29	of	of	IN
cord-006860-a3b8hyyr	2370	30	other	other	JJ
cord-006860-a3b8hyyr	2370	31	low	low	JJ
cord-006860-a3b8hyyr	2370	32	molecular	molecular	JJ
cord-006860-a3b8hyyr	2370	33	weight	weight	NN
cord-006860-a3b8hyyr	2370	34	heparins	heparin	NNS
cord-006860-a3b8hyyr	2370	35	.	.	.
cord-006860-a3b8hyyr	2371	1	These	these	DT
cord-006860-a3b8hyyr	2371	2	studies	study	NNS
cord-006860-a3b8hyyr	2371	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	2371	4	that	that	IN
cord-006860-a3b8hyyr	2371	5	SR	SR	NNP
cord-006860-a3b8hyyr	2371	6	80486A	80486A	NNP
cord-006860-a3b8hyyr	2371	7	is	be	VBZ
cord-006860-a3b8hyyr	2371	8	capable	capable	JJ
cord-006860-a3b8hyyr	2371	9	of	of	IN
cord-006860-a3b8hyyr	2371	10	producing	produce	VBG
cord-006860-a3b8hyyr	2371	11	similar	similar	JJ
cord-006860-a3b8hyyr	2371	12	pharmacologic	pharmacologic	JJ
cord-006860-a3b8hyyr	2371	13	effects	effect	NNS
cord-006860-a3b8hyyr	2371	14	as	as	IN
cord-006860-a3b8hyyr	2371	15	other	other	JJ
cord-006860-a3b8hyyr	2371	16	low	low	JJ
cord-006860-a3b8hyyr	2371	17	molecular	molecular	JJ
cord-006860-a3b8hyyr	2371	18	weight	weight	NN
cord-006860-a3b8hyyr	2371	19	heparms	heparms	NNP
cord-006860-a3b8hyyr	2371	20	,	,	,
cord-006860-a3b8hyyr	2371	21	however	however	RB
cord-006860-a3b8hyyr	2371	22	,	,	,
cord-006860-a3b8hyyr	2371	23	additional	additional	JJ
cord-006860-a3b8hyyr	2371	24	optimization	optimization	NN
cord-006860-a3b8hyyr	2371	25	studies	study	NNS
cord-006860-a3b8hyyr	2371	26	are	be	VBP
cord-006860-a3b8hyyr	2371	27	required	require	VBN
cord-006860-a3b8hyyr	2371	28	for	for	IN
cord-006860-a3b8hyyr	2371	29	demonslrating	demonslrate	VBG
cord-006860-a3b8hyyr	2371	30	product	product	NN
cord-006860-a3b8hyyr	2371	31	equivalence	equivalence	NN
cord-006860-a3b8hyyr	2371	32	.	.	.
cord-006860-a3b8hyyr	2372	1	Limited	limited	JJ
cord-006860-a3b8hyyr	2372	2	information	information	NN
cord-006860-a3b8hyyr	2372	3	on	on	IN
cord-006860-a3b8hyyr	2372	4	the	the	DT
cord-006860-a3b8hyyr	2372	5	comparative	comparative	JJ
cord-006860-a3b8hyyr	2372	6	pharmacoldnetics	pharmacoldnetic	NNS
cord-006860-a3b8hyyr	2372	7	of	of	IN
cord-006860-a3b8hyyr	2372	8	low	low	JJ
cord-006860-a3b8hyyr	2372	9	molecular	molecular	JJ
cord-006860-a3b8hyyr	2372	10	weight	weight	NN
cord-006860-a3b8hyyr	2372	11	heparin	heparin	NN
cord-006860-a3b8hyyr	2372	12	(	(	-LRB-
cord-006860-a3b8hyyr	2372	13	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2372	14	)	)	-RRB-
cord-006860-a3b8hyyr	2372	15	is	be	VBZ
cord-006860-a3b8hyyr	2372	16	available	available	JJ
cord-006860-a3b8hyyr	2372	17	on	on	IN
cord-006860-a3b8hyyr	2372	18	the	the	DT
cord-006860-a3b8hyyr	2372	19	data	datum	NNS
cord-006860-a3b8hyyr	2372	20	obtained	obtain	VBN
cord-006860-a3b8hyyr	2372	21	from	from	IN
cord-006860-a3b8hyyr	2372	22	APTT	APTT	NNP
cord-006860-a3b8hyyr	2372	23	,	,	,
cord-006860-a3b8hyyr	2372	24	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2372	25	,	,	,
cord-006860-a3b8hyyr	2372	26	anti	anti	JJ
cord-006860-a3b8hyyr	2372	27	-	-	NNP
cord-006860-a3b8hyyr	2372	28	Xa	Xa	NNP
cord-006860-a3b8hyyr	2372	29	and	and	CC
cord-006860-a3b8hyyr	2372	30	antMIa	antMIa	NNP
cord-006860-a3b8hyyr	2372	31	assays	assay	NNS
cord-006860-a3b8hyyr	2372	32	.	.	.
cord-006860-a3b8hyyr	2373	1	Since	since	IN
cord-006860-a3b8hyyr	2373	2	these	these	DT
cord-006860-a3b8hyyr	2373	3	drugs	drug	NNS
cord-006860-a3b8hyyr	2373	4	are	be	VBP
cord-006860-a3b8hyyr	2373	5	currently	currently	RB
cord-006860-a3b8hyyr	2373	6	used	use	VBN
cord-006860-a3b8hyyr	2373	7	for	for	IN
cord-006860-a3b8hyyr	2373	8	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	2373	9	indications	indication	NNS
cord-006860-a3b8hyyr	2373	10	using	use	VBG
cord-006860-a3b8hyyr	2373	11	relatively	relatively	RB
cord-006860-a3b8hyyr	2373	12	high	high	JJ
cord-006860-a3b8hyyr	2373	13	dosages	dosage	NNS
cord-006860-a3b8hyyr	2373	14	and	and	CC
cord-006860-a3b8hyyr	2373	15	intravenous	intravenous	JJ
cord-006860-a3b8hyyr	2373	16	administration	administration	NN
cord-006860-a3b8hyyr	2373	17	.	.	.
cord-006860-a3b8hyyr	2374	1	APTT	APTT	NNP
cord-006860-a3b8hyyr	2374	2	,	,	,
cord-006860-a3b8hyyr	2374	3	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2374	4	and	and	CC
cord-006860-a3b8hyyr	2374	5	antMIa	antMIa	NNP
cord-006860-a3b8hyyr	2374	6	test	test	NN
cord-006860-a3b8hyyr	2374	7	may	may	MD
cord-006860-a3b8hyyr	2374	8	be	be	VB
cord-006860-a3b8hyyr	2374	9	valuable	valuable	JJ
cord-006860-a3b8hyyr	2374	10	in	in	IN
cord-006860-a3b8hyyr	2374	11	the	the	DT
cord-006860-a3b8hyyr	2374	12	assessment	assessment	NN
cord-006860-a3b8hyyr	2374	13	of	of	IN
cord-006860-a3b8hyyr	2374	14	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2374	15	effects	effect	NNS
cord-006860-a3b8hyyr	2374	16	.	.	.
cord-006860-a3b8hyyr	2375	1	In	in	IN
cord-006860-a3b8hyyr	2375	2	order	order	NN
cord-006860-a3b8hyyr	2375	3	to	to	TO
cord-006860-a3b8hyyr	2375	4	investigate	investigate	VB
cord-006860-a3b8hyyr	2375	5	the	the	DT
cord-006860-a3b8hyyr	2375	6	relative	relative	JJ
cord-006860-a3b8hyyr	2375	7	pharmacokinetics	pharmacokinetic	NNS
cord-006860-a3b8hyyr	2375	8	of	of	IN
cord-006860-a3b8hyyr	2375	9	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2375	10	using	use	VBG
cord-006860-a3b8hyyr	2375	11	APT'I	APT'I	NNP
cord-006860-a3b8hyyr	2375	12	'	'	''
cord-006860-a3b8hyyr	2375	13	,	,	,
cord-006860-a3b8hyyr	2375	14	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2375	15	,	,	,
cord-006860-a3b8hyyr	2375	16	anti	anti	JJ
cord-006860-a3b8hyyr	2375	17	-	-	JJ
cord-006860-a3b8hyyr	2375	18	Xa	xa	JJ
cord-006860-a3b8hyyr	2375	19	and	and	CC
cord-006860-a3b8hyyr	2375	20	anti	anti	JJ
cord-006860-a3b8hyyr	2375	21	-	-	JJ
cord-006860-a3b8hyyr	2375	22	IIa	iia	JJ
cord-006860-a3b8hyyr	2375	23	methods	method	NNS
cord-006860-a3b8hyyr	2375	24	,	,	,
cord-006860-a3b8hyyr	2375	25	Certoparin	Certoparin	NNP
cord-006860-a3b8hyyr	2375	26	(	(	-LRB-
cord-006860-a3b8hyyr	2375	27	Sandoz	Sandoz	NNP
cord-006860-a3b8hyyr	2375	28	,	,	,
cord-006860-a3b8hyyr	2375	29	Basel	Basel	NNP
cord-006860-a3b8hyyr	2375	30	,	,	,
cord-006860-a3b8hyyr	2375	31	Switzerland	Switzerland	NNP
cord-006860-a3b8hyyr	2375	32	)	)	-RRB-
cord-006860-a3b8hyyr	2375	33	was	be	VBD
cord-006860-a3b8hyyr	2375	34	administered	administer	VBN
cord-006860-a3b8hyyr	2375	35	to	to	IN
cord-006860-a3b8hyyr	2375	36	individual	individual	JJ
cord-006860-a3b8hyyr	2375	37	groups	group	NNS
cord-006860-a3b8hyyr	2375	38	of	of	IN
cord-006860-a3b8hyyr	2375	39	healthy	healthy	JJ
cord-006860-a3b8hyyr	2375	40	male	male	JJ
cord-006860-a3b8hyyr	2375	41	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	2375	42	(	(	-LRB-
cord-006860-a3b8hyyr	2375	43	52	52	CD
cord-006860-a3b8hyyr	2375	44	-	-	SYM
cord-006860-a3b8hyyr	2375	45	70	70	CD
cord-006860-a3b8hyyr	2375	46	kg	kg	NNS
cord-006860-a3b8hyyr	2375	47	)	)	-RRB-
cord-006860-a3b8hyyr	2375	48	via	via	IN
cord-006860-a3b8hyyr	2375	49	intravenous	intravenous	JJ
cord-006860-a3b8hyyr	2375	50	(	(	-LRB-
cord-006860-a3b8hyyr	2375	51	30	30	CD
cord-006860-a3b8hyyr	2375	52	mg	mg	CD
cord-006860-a3b8hyyr	2375	53	)	)	-RRB-
cord-006860-a3b8hyyr	2375	54	and	and	CC
cord-006860-a3b8hyyr	2375	55	subcutaneous	subcutaneous	JJ
cord-006860-a3b8hyyr	2375	56	(	(	-LRB-
cord-006860-a3b8hyyr	2375	57	50	50	CD
cord-006860-a3b8hyyr	2375	58	nag	nag	NN
cord-006860-a3b8hyyr	2375	59	)	)	-RRB-
cord-006860-a3b8hyyr	2375	60	routes	route	NNS
cord-006860-a3b8hyyr	2375	61	in	in	IN
cord-006860-a3b8hyyr	2375	62	a	a	DT
cord-006860-a3b8hyyr	2375	63	crossover	crossover	NN
cord-006860-a3b8hyyr	2375	64	study	study	NN
cord-006860-a3b8hyyr	2375	65	.	.	.
cord-006860-a3b8hyyr	2376	1	Blood	blood	NN
cord-006860-a3b8hyyr	2376	2	samples	sample	NNS
cord-006860-a3b8hyyr	2376	3	were	be	VBD
cord-006860-a3b8hyyr	2376	4	drawn	draw	VBN
cord-006860-a3b8hyyr	2376	5	at	at	IN
cord-006860-a3b8hyyr	2376	6	0	0	CD
cord-006860-a3b8hyyr	2376	7	,	,	,
cord-006860-a3b8hyyr	2376	8	5	5	CD
cord-006860-a3b8hyyr	2376	9	,	,	,
cord-006860-a3b8hyyr	2376	10	15	15	CD
cord-006860-a3b8hyyr	2376	11	,	,	,
cord-006860-a3b8hyyr	2376	12	30	30	CD
cord-006860-a3b8hyyr	2376	13	,	,	,
cord-006860-a3b8hyyr	2376	14	60	60	CD
cord-006860-a3b8hyyr	2376	15	,	,	,
cord-006860-a3b8hyyr	2376	16	90	90	CD
cord-006860-a3b8hyyr	2376	17	,	,	,
cord-006860-a3b8hyyr	2376	18	180	180	CD
cord-006860-a3b8hyyr	2376	19	,	,	,
cord-006860-a3b8hyyr	2376	20	360	360	CD
cord-006860-a3b8hyyr	2376	21	,	,	,
cord-006860-a3b8hyyr	2376	22	540	540	CD
cord-006860-a3b8hyyr	2376	23	and	and	CC
cord-006860-a3b8hyyr	2376	24	720	720	CD
cord-006860-a3b8hyyr	2376	25	minutes	minute	NNS
cord-006860-a3b8hyyr	2376	26	.	.	.
cord-006860-a3b8hyyr	2377	1	Using	use	VBG
cord-006860-a3b8hyyr	2377	2	a	a	DT
cord-006860-a3b8hyyr	2377	3	baseline	baseline	JJ
cord-006860-a3b8hyyr	2377	4	pool	pool	NN
cord-006860-a3b8hyyr	2377	5	plasma	plasma	NN
cord-006860-a3b8hyyr	2377	6	obtained	obtain	VBN
cord-006860-a3b8hyyr	2377	7	from	from	IN
cord-006860-a3b8hyyr	2377	8	the	the	DT
cord-006860-a3b8hyyr	2377	9	same	same	JJ
cord-006860-a3b8hyyr	2377	10	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	2377	11	,	,	,
cord-006860-a3b8hyyr	2377	12	calibration	calibration	NN
cord-006860-a3b8hyyr	2377	13	curves	curve	NNS
cord-006860-a3b8hyyr	2377	14	for	for	IN
cord-006860-a3b8hyyr	2377	15	each	each	DT
cord-006860-a3b8hyyr	2377	16	of	of	IN
cord-006860-a3b8hyyr	2377	17	the	the	DT
cord-006860-a3b8hyyr	2377	18	individual	individual	JJ
cord-006860-a3b8hyyr	2377	19	tests	test	NNS
cord-006860-a3b8hyyr	2377	20	were	be	VBD
cord-006860-a3b8hyyr	2377	21	constructed	construct	VBN
cord-006860-a3b8hyyr	2377	22	to	to	TO
cord-006860-a3b8hyyr	2377	23	extrapolate	extrapolate	VB
cord-006860-a3b8hyyr	2377	24	circulating	circulate	VBG
cord-006860-a3b8hyyr	2377	25	levels	level	NNS
cord-006860-a3b8hyyr	2377	26	of	of	IN
cord-006860-a3b8hyyr	2377	27	Certoparin	Certoparin	NNP
cord-006860-a3b8hyyr	2377	28	.	.	.
cord-006860-a3b8hyyr	2378	1	A	a	DT
cord-006860-a3b8hyyr	2378	2	non	non	JJ
cord-006860-a3b8hyyr	2378	3	-	-	JJ
cord-006860-a3b8hyyr	2378	4	compartmental	compartmental	JJ
cord-006860-a3b8hyyr	2378	5	model	model	NN
cord-006860-a3b8hyyr	2378	6	using	use	VBG
cord-006860-a3b8hyyr	2378	7	trapezoidal	trapezoidal	JJ
cord-006860-a3b8hyyr	2378	8	technique	technique	NN
cord-006860-a3b8hyyr	2378	9	was	be	VBD
cord-006860-a3b8hyyr	2378	10	used	use	VBN
cord-006860-a3b8hyyr	2378	11	to	to	TO
cord-006860-a3b8hyyr	2378	12	obtain	obtain	VB
cord-006860-a3b8hyyr	2378	13	pharmacokinetic	pharmacokinetic	JJ
cord-006860-a3b8hyyr	2378	14	parameters	parameter	NNS
cord-006860-a3b8hyyr	2378	15	such	such	JJ
cord-006860-a3b8hyyr	2378	16	as	as	IN
cord-006860-a3b8hyyr	2378	17	t	t	NNP
cord-006860-a3b8hyyr	2378	18	1/2	1/2	CD
cord-006860-a3b8hyyr	2378	19	,	,	,
cord-006860-a3b8hyyr	2378	20	Vd	Vd	NNP
cord-006860-a3b8hyyr	2378	21	,	,	,
cord-006860-a3b8hyyr	2378	22	and	and	CC
cord-006860-a3b8hyyr	2378	23	CLsys	CLsys	NNP
cord-006860-a3b8hyyr	2378	24	.	.	.
cord-006860-a3b8hyyr	2379	1	In	in	IN
cord-006860-a3b8hyyr	2379	2	the	the	DT
cord-006860-a3b8hyyr	2379	3	intravenous	intravenous	JJ
cord-006860-a3b8hyyr	2379	4	studies	study	NNS
cord-006860-a3b8hyyr	2379	5	,	,	,
cord-006860-a3b8hyyr	2379	6	the	the	DT
cord-006860-a3b8hyyr	2379	7	t	t	NN
cord-006860-a3b8hyyr	2379	8	1/2	1/2	CD
cord-006860-a3b8hyyr	2379	9	was	be	VBD
cord-006860-a3b8hyyr	2379	10	found	find	VBN
cord-006860-a3b8hyyr	2379	11	to	to	TO
cord-006860-a3b8hyyr	2379	12	be	be	VB
cord-006860-a3b8hyyr	2379	13	dosedependent	dosedependent	NN
cord-006860-a3b8hyyr	2379	14	for	for	IN
cord-006860-a3b8hyyr	2379	15	APTT	APTT	NNP
cord-006860-a3b8hyyr	2379	16	,	,	,
cord-006860-a3b8hyyr	2379	17	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2379	18	,	,	,
cord-006860-a3b8hyyr	2379	19	anti	anti	JJ
cord-006860-a3b8hyyr	2379	20	-	-	NNP
cord-006860-a3b8hyyr	2379	21	Xa	Xa	NNP
cord-006860-a3b8hyyr	2379	22	and	and	CC
cord-006860-a3b8hyyr	2379	23	antM]a	antm]a	VB
cord-006860-a3b8hyyr	2379	24	.	.	.
cord-006860-a3b8hyyr	2380	1	The	the	DT
cord-006860-a3b8hyyr	2380	2	AUC	AUC	NNP
cord-006860-a3b8hyyr	2380	3	,	,	,
cord-006860-a3b8hyyr	2380	4	however	however	RB
cord-006860-a3b8hyyr	2380	5	,	,	,
cord-006860-a3b8hyyr	2380	6	was	be	VBD
cord-006860-a3b8hyyr	2380	7	significantly	significantly	RB
cord-006860-a3b8hyyr	2380	8	different	different	JJ
cord-006860-a3b8hyyr	2380	9	for	for	IN
cord-006860-a3b8hyyr	2380	10	each	each	DT
cord-006860-a3b8hyyr	2380	11	test	test	NN
cord-006860-a3b8hyyr	2380	12	and	and	CC
cord-006860-a3b8hyyr	2380	13	was	be	VBD
cord-006860-a3b8hyyr	2380	14	dose	dose	RB
cord-006860-a3b8hyyr	2380	15	-	-	HYPH
cord-006860-a3b8hyyr	2380	16	dependent	dependent	JJ
cord-006860-a3b8hyyr	2380	17	following	follow	VBG
cord-006860-a3b8hyyr	2380	18	the	the	DT
cord-006860-a3b8hyyr	2380	19	order	order	NN
cord-006860-a3b8hyyr	2380	20	:	:	:
cord-006860-a3b8hyyr	2381	1	APTT	APTT	NNP
cord-006860-a3b8hyyr	2381	2	<	<	XX
cord-006860-a3b8hyyr	2381	3	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2381	4	<	<	XX
cord-006860-a3b8hyyr	2381	5	Anti	Anti	NNP
cord-006860-a3b8hyyr	2381	6	-	-	NNP
cord-006860-a3b8hyyr	2381	7	Xa	Xa	NNP
cord-006860-a3b8hyyr	2381	8	<	<	XX
cord-006860-a3b8hyyr	2381	9	anti	anti	NNP
cord-006860-a3b8hyyr	2381	10	-	-	NNP
cord-006860-a3b8hyyr	2381	11	IIa	IIa	NNP
cord-006860-a3b8hyyr	2381	12	.	.	.
cord-006860-a3b8hyyr	2382	1	In	in	IN
cord-006860-a3b8hyyr	2382	2	the	the	DT
cord-006860-a3b8hyyr	2382	3	subcutaneous	subcutaneous	JJ
cord-006860-a3b8hyyr	2382	4	studies	study	NNS
cord-006860-a3b8hyyr	2382	5	,	,	,
cord-006860-a3b8hyyr	2382	6	1the	1the	DT
cord-006860-a3b8hyyr	2382	7	t	t	NNP
cord-006860-a3b8hyyr	2382	8	1/2	1/2	CD
cord-006860-a3b8hyyr	2382	9	was	be	VBD
cord-006860-a3b8hyyr	2382	10	both	both	DT
cord-006860-a3b8hyyr	2382	11	test	test	NN
cord-006860-a3b8hyyr	2382	12	and	and	CC
cord-006860-a3b8hyyr	2382	13	dose	dose	NN
cord-006860-a3b8hyyr	2382	14	-	-	HYPH
cord-006860-a3b8hyyr	2382	15	dependent	dependent	JJ
cord-006860-a3b8hyyr	2382	16	.	.	.
cord-006860-a3b8hyyr	2383	1	The	the	DT
cord-006860-a3b8hyyr	2383	2	AUC	AUC	NNP
cord-006860-a3b8hyyr	2383	3	was	be	VBD
cord-006860-a3b8hyyr	2383	4	also	also	RB
cord-006860-a3b8hyyr	2383	5	dose	dose	NN
cord-006860-a3b8hyyr	2383	6	-	-	HYPH
cord-006860-a3b8hyyr	2383	7	dependent	dependent	JJ
cord-006860-a3b8hyyr	2383	8	and	and	CC
cord-006860-a3b8hyyr	2383	9	followed	follow	VBD
cord-006860-a3b8hyyr	2383	10	the	the	DT
cord-006860-a3b8hyyr	2383	11	order	order	NN
cord-006860-a3b8hyyr	2383	12	:	:	:
cord-006860-a3b8hyyr	2384	1	anti	anti	JJ
cord-006860-a3b8hyyr	2384	2	-	-	JJ
cord-006860-a3b8hyyr	2384	3	Xa	Xa	NNP
cord-006860-a3b8hyyr	2384	4	>	>	XX
cord-006860-a3b8hyyr	2384	5	Heptest	heptest	NN
cord-006860-a3b8hyyr	2384	6	>	>	XX
cord-006860-a3b8hyyr	2385	1	APTT	APTT	NNP
cord-006860-a3b8hyyr	2386	1	>	>	XX
cord-006860-a3b8hyyr	2387	1	antMIa	antMIa	NNP
cord-006860-a3b8hyyr	2387	2	.	.	.
cord-006860-a3b8hyyr	2388	1	The	the	DT
cord-006860-a3b8hyyr	2388	2	CLsys	CLsys	NNP
cord-006860-a3b8hyyr	2388	3	of	of	IN
cord-006860-a3b8hyyr	2388	4	the	the	DT
cord-006860-a3b8hyyr	2388	5	antMa	antMa	NNS
cord-006860-a3b8hyyr	2388	6	was	be	VBD
cord-006860-a3b8hyyr	2388	7	much	much	RB
cord-006860-a3b8hyyr	2388	8	faster	fast	JJR
cord-006860-a3b8hyyr	2388	9	in	in	IN
cord-006860-a3b8hyyr	2388	10	comparison	comparison	NN
cord-006860-a3b8hyyr	2388	11	to	to	IN
cord-006860-a3b8hyyr	2388	12	the	the	DT
cord-006860-a3b8hyyr	2388	13	other	other	JJ
cord-006860-a3b8hyyr	2388	14	tests	test	NNS
cord-006860-a3b8hyyr	2388	15	.	.	.
cord-006860-a3b8hyyr	2389	1	The	the	DT
cord-006860-a3b8hyyr	2389	2	CLsys	CLsys	NNP
cord-006860-a3b8hyyr	2389	3	of	of	IN
cord-006860-a3b8hyyr	2389	4	the	the	DT
cord-006860-a3b8hyyr	2389	5	APTT	APTT	NNP
cord-006860-a3b8hyyr	2389	6	and	and	CC
cord-006860-a3b8hyyr	2389	7	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2389	8	was	be	VBD
cord-006860-a3b8hyyr	2389	9	independent	independent	JJ
cord-006860-a3b8hyyr	2389	10	of	of	IN
cord-006860-a3b8hyyr	2389	11	dose	dose	NN
cord-006860-a3b8hyyr	2389	12	.	.	.
cord-006860-a3b8hyyr	2390	1	However	however	RB
cord-006860-a3b8hyyr	2390	2	,	,	,
cord-006860-a3b8hyyr	2390	3	anti	anti	JJ
cord-006860-a3b8hyyr	2390	4	-	-	NNP
cord-006860-a3b8hyyr	2390	5	Xa	Xa	NNP
cord-006860-a3b8hyyr	2390	6	CLsys	CLsys	NNP
cord-006860-a3b8hyyr	2390	7	by	by	IN
cord-006860-a3b8hyyr	2390	8	this	this	DT
cord-006860-a3b8hyyr	2390	9	route	route	NN
cord-006860-a3b8hyyr	2390	10	was	be	VBD
cord-006860-a3b8hyyr	2390	11	lower	low	JJR
cord-006860-a3b8hyyr	2390	12	than	than	IN
cord-006860-a3b8hyyr	2390	13	other	other	JJ
cord-006860-a3b8hyyr	2390	14	tests	test	NNS
cord-006860-a3b8hyyr	2390	15	.	.	.
cord-006860-a3b8hyyr	2391	1	The	the	DT
cord-006860-a3b8hyyr	2391	2	apparent	apparent	JJ
cord-006860-a3b8hyyr	2391	3	Vd	Vd	NNP
cord-006860-a3b8hyyr	2391	4	followed	follow	VBD
cord-006860-a3b8hyyr	2391	5	the	the	DT
cord-006860-a3b8hyyr	2391	6	order	order	NN
cord-006860-a3b8hyyr	2391	7	APTT	APTT	NNP
cord-006860-a3b8hyyr	2392	1	>	>	XX
cord-006860-a3b8hyyr	2393	1	antMIa	antMIa	NNP
cord-006860-a3b8hyyr	2394	1	>	>	XX
cord-006860-a3b8hyyr	2395	1	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2396	1	>	>	XX
cord-006860-a3b8hyyr	2397	1	anti	anti	NNP
cord-006860-a3b8hyyr	2397	2	-	-	NNP
cord-006860-a3b8hyyr	2397	3	Xa	Xa	NNP
cord-006860-a3b8hyyr	2397	4	.	.	.
cord-006860-a3b8hyyr	2398	1	The	the	DT
cord-006860-a3b8hyyr	2398	2	bioavailability	bioavailability	NN
cord-006860-a3b8hyyr	2398	3	of	of	IN
cord-006860-a3b8hyyr	2398	4	the	the	DT
cord-006860-a3b8hyyr	2398	5	Certoparin	Certoparin	NNP
cord-006860-a3b8hyyr	2398	6	as	as	IN
cord-006860-a3b8hyyr	2398	7	measured	measure	VBN
cord-006860-a3b8hyyr	2398	8	by	by	IN
cord-006860-a3b8hyyr	2398	9	various	various	JJ
cord-006860-a3b8hyyr	2398	10	tests	test	NNS
cord-006860-a3b8hyyr	2398	11	ranged	range	VBD
cord-006860-a3b8hyyr	2398	12	from	from	IN
cord-006860-a3b8hyyr	2398	13	81	81	CD
cord-006860-a3b8hyyr	2398	14	-	-	SYM
cord-006860-a3b8hyyr	2398	15	119	119	CD
cord-006860-a3b8hyyr	2398	16	%	%	NN
cord-006860-a3b8hyyr	2398	17	.	.	.
cord-006860-a3b8hyyr	2399	1	These	these	DT
cord-006860-a3b8hyyr	2399	2	studies	study	NNS
cord-006860-a3b8hyyr	2399	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	2399	4	that	that	IN
cord-006860-a3b8hyyr	2399	5	beside	beside	IN
cord-006860-a3b8hyyr	2399	6	providing	provide	VBG
cord-006860-a3b8hyyr	2399	7	pharmacokinetic	pharmacokinetic	JJ
cord-006860-a3b8hyyr	2399	8	data	datum	NNS
cord-006860-a3b8hyyr	2399	9	,	,	,
cord-006860-a3b8hyyr	2399	10	APTT	APTT	NNP
cord-006860-a3b8hyyr	2399	11	,	,	,
cord-006860-a3b8hyyr	2399	12	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2399	13	and	and	CC
cord-006860-a3b8hyyr	2399	14	anti	anti	JJ
cord-006860-a3b8hyyr	2399	15	-	-	JJ
cord-006860-a3b8hyyr	2399	16	IIa	iia	JJ
cord-006860-a3b8hyyr	2399	17	assays	assay	NNS
cord-006860-a3b8hyyr	2399	18	may	may	MD
cord-006860-a3b8hyyr	2399	19	provide	provide	VB
cord-006860-a3b8hyyr	2399	20	useful	useful	JJ
cord-006860-a3b8hyyr	2399	21	data	datum	NNS
cord-006860-a3b8hyyr	2399	22	on	on	IN
cord-006860-a3b8hyyr	2399	23	thier	thier	PRP$
cord-006860-a3b8hyyr	2399	24	safety	safety	NN
cord-006860-a3b8hyyr	2399	25	and	and	CC
cord-006860-a3b8hyyr	2399	26	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2399	27	at	at	IN
cord-006860-a3b8hyyr	2399	28	high	high	JJ
cord-006860-a3b8hyyr	2399	29	dosages	dosage	NNS
cord-006860-a3b8hyyr	2399	30	.	.	.
cord-006860-a3b8hyyr	2400	1	The	the	DT
cord-006860-a3b8hyyr	2400	2	immunological	immunological	JJ
cord-006860-a3b8hyyr	2400	3	type	type	NN
cord-006860-a3b8hyyr	2400	4	of	of	IN
cord-006860-a3b8hyyr	2400	5	heparin	heparin	NN
cord-006860-a3b8hyyr	2400	6	associated	associated	NNP
cord-006860-a3b8hyyr	2400	7	thrombocytopenla	thrombocytopenla	NNP
cord-006860-a3b8hyyr	2400	8	(	(	-LRB-
cord-006860-a3b8hyyr	2400	9	HAT	HAT	NNP
cord-006860-a3b8hyyr	2400	10	II	II	NNP
cord-006860-a3b8hyyr	2400	11	)	)	-RRB-
cord-006860-a3b8hyyr	2400	12	is	be	VBZ
cord-006860-a3b8hyyr	2400	13	a	a	DT
cord-006860-a3b8hyyr	2400	14	severe	severe	JJ
cord-006860-a3b8hyyr	2400	15	complication	complication	NN
cord-006860-a3b8hyyr	2400	16	of	of	IN
cord-006860-a3b8hyyr	2400	17	heparin	heparin	JJ
cord-006860-a3b8hyyr	2400	18	treatment	treatment	NN
cord-006860-a3b8hyyr	2400	19	and	and	CC
cord-006860-a3b8hyyr	2400	20	is	be	VBZ
cord-006860-a3b8hyyr	2400	21	associated	associate	VBN
cord-006860-a3b8hyyr	2400	22	with	with	IN
cord-006860-a3b8hyyr	2400	23	arterial	arterial	JJ
cord-006860-a3b8hyyr	2400	24	and	and	CC
cord-006860-a3b8hyyr	2400	25	venous	venous	JJ
cord-006860-a3b8hyyr	2400	26	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2400	27	.	.	.
cord-006860-a3b8hyyr	2401	1	Only	only	RB
cord-006860-a3b8hyyr	2401	2	patients	patient	NNS
cord-006860-a3b8hyyr	2401	3	with	with	IN
cord-006860-a3b8hyyr	2401	4	absolute	absolute	JJ
cord-006860-a3b8hyyr	2401	5	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2401	6	have	have	VBP
cord-006860-a3b8hyyr	2401	7	prompted	prompt	VBN
cord-006860-a3b8hyyr	2401	8	suspicion	suspicion	NN
cord-006860-a3b8hyyr	2401	9	of	of	IN
cord-006860-a3b8hyyr	2401	10	HAT	hat	NN
cord-006860-a3b8hyyr	2401	11	in	in	IN
cord-006860-a3b8hyyr	2401	12	clinical	clinical	JJ
cord-006860-a3b8hyyr	2401	13	practice	practice	NN
cord-006860-a3b8hyyr	2401	14	.	.	.
cord-006860-a3b8hyyr	2402	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2402	2	report	report	VBP
cord-006860-a3b8hyyr	2402	3	on	on	IN
cord-006860-a3b8hyyr	2402	4	a	a	DT
cord-006860-a3b8hyyr	2402	5	44	44	CD
cord-006860-a3b8hyyr	2402	6	year	year	NN
cord-006860-a3b8hyyr	2402	7	old	old	JJ
cord-006860-a3b8hyyr	2402	8	male	male	NN
cord-006860-a3b8hyyr	2402	9	,	,	,
cord-006860-a3b8hyyr	2402	10	who	who	WP
cord-006860-a3b8hyyr	2402	11	developed	develop	VBD
cord-006860-a3b8hyyr	2402	12	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	2402	13	episodes	episode	NNS
cord-006860-a3b8hyyr	2402	14	after	after	IN
cord-006860-a3b8hyyr	2402	15	coronary	coronary	JJ
cord-006860-a3b8hyyr	2402	16	angiography	angiography	NN
cord-006860-a3b8hyyr	2402	17	like	like	IN
cord-006860-a3b8hyyr	2402	18	reinfarction	reinfarction	NN
cord-006860-a3b8hyyr	2402	19	and	and	CC
cord-006860-a3b8hyyr	2402	20	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	2402	21	episodes	episode	NNS
cord-006860-a3b8hyyr	2402	22	of	of	IN
cord-006860-a3b8hyyr	2402	23	A.	a.	NN
cord-006860-a3b8hyyr	2402	24	brachialis	brachialis	NNP
cord-006860-a3b8hyyr	2402	25	.	.	.
cord-006860-a3b8hyyr	2403	1	Fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	2403	2	therapy	therapy	NN
cord-006860-a3b8hyyr	2403	3	combined	combine	VBN
cord-006860-a3b8hyyr	2403	4	with	with	IN
cord-006860-a3b8hyyr	2403	5	i.v	i.v	NNP
cord-006860-a3b8hyyr	2403	6	.	.	.
cord-006860-a3b8hyyr	2404	1	unffactionated	unffactionated	JJ
cord-006860-a3b8hyyr	2404	2	heparin	heparin	NNP
cord-006860-a3b8hyyr	2404	3	treatment	treatment	NN
cord-006860-a3b8hyyr	2404	4	was	be	VBD
cord-006860-a3b8hyyr	2404	5	the	the	DT
cord-006860-a3b8hyyr	2404	6	therapy	therapy	NN
cord-006860-a3b8hyyr	2404	7	of	of	IN
cord-006860-a3b8hyyr	2404	8	choice	choice	NN
cord-006860-a3b8hyyr	2404	9	and	and	CC
cord-006860-a3b8hyyr	2404	10	was	be	VBD
cord-006860-a3b8hyyr	2404	11	followed	follow	VBN
cord-006860-a3b8hyyr	2404	12	by	by	IN
cord-006860-a3b8hyyr	2404	13	severe	severe	JJ
cord-006860-a3b8hyyr	2404	14	fua	fua	NNP
cord-006860-a3b8hyyr	2404	15	~	~	NFP
cord-006860-a3b8hyyr	2404	16	er	er	UH
cord-006860-a3b8hyyr	2404	17	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	2404	18	adverse	adverse	JJ
cord-006860-a3b8hyyr	2404	19	effects	effect	NNS
cord-006860-a3b8hyyr	2404	20	.	.	.
cord-006860-a3b8hyyr	2405	1	Besides	besides	IN
cord-006860-a3b8hyyr	2405	2	an	an	DT
cord-006860-a3b8hyyr	2405	3	impaired	impaired	JJ
cord-006860-a3b8hyyr	2405	4	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	2405	5	response	response	NN
cord-006860-a3b8hyyr	2405	6	and	and	CC
cord-006860-a3b8hyyr	2405	7	elevated	elevated	JJ
cord-006860-a3b8hyyr	2405	8	antiphospholipid	antiphospholipid	NNP
cord-006860-a3b8hyyr	2405	9	anitbodies	anitbodie	NNS
cord-006860-a3b8hyyr	2405	10	,	,	,
cord-006860-a3b8hyyr	2405	11	we	-PRON-	PRP
cord-006860-a3b8hyyr	2405	12	diagnosed	diagnose	VBD
cord-006860-a3b8hyyr	2405	13	HAT	hat	NN
cord-006860-a3b8hyyr	2405	14	type	type	NN
cord-006860-a3b8hyyr	2405	15	II	II	NNP
cord-006860-a3b8hyyr	2405	16	in	in	IN
cord-006860-a3b8hyyr	2405	17	HIPA	HIPA	NNP
cord-006860-a3b8hyyr	2405	18	and	and	CC
cord-006860-a3b8hyyr	2405	19	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	2406	1	(	(	-LRB-
cord-006860-a3b8hyyr	2406	2	Stago	Stago	NNP
cord-006860-a3b8hyyr	2406	3	-	-	HYPH
cord-006860-a3b8hyyr	2406	4	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	2406	5	,	,	,
cord-006860-a3b8hyyr	2406	6	Marmheim	Marmheim	NNP
cord-006860-a3b8hyyr	2406	7	)	)	-RRB-
cord-006860-a3b8hyyr	2406	8	.	.	.
cord-006860-a3b8hyyr	2407	1	This	this	DT
cord-006860-a3b8hyyr	2407	2	special	special	JJ
cord-006860-a3b8hyyr	2407	3	patient	patient	NN
cord-006860-a3b8hyyr	2407	4	had	have	VBD
cord-006860-a3b8hyyr	2407	5	platelet	platelet	NN
cord-006860-a3b8hyyr	2407	6	counts	count	NNS
cord-006860-a3b8hyyr	2407	7	within	within	IN
cord-006860-a3b8hyyr	2407	8	a	a	DT
cord-006860-a3b8hyyr	2407	9	normal	normal	JJ
cord-006860-a3b8hyyr	2407	10	range	range	NN
cord-006860-a3b8hyyr	2407	11	,	,	,
cord-006860-a3b8hyyr	2407	12	when	when	WRB
cord-006860-a3b8hyyr	2407	13	developing	develop	VBG
cord-006860-a3b8hyyr	2407	14	the	the	DT
cord-006860-a3b8hyyr	2407	15	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	2407	16	episodes	episode	NNS
cord-006860-a3b8hyyr	2407	17	.	.	.
cord-006860-a3b8hyyr	2408	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	2408	2	appears	appear	VBZ
cord-006860-a3b8hyyr	2408	3	that	that	IN
cord-006860-a3b8hyyr	2408	4	the	the	DT
cord-006860-a3b8hyyr	2408	5	normal	normal	JJ
cord-006860-a3b8hyyr	2408	6	platelet	platelet	NN
cord-006860-a3b8hyyr	2408	7	count	count	NN
cord-006860-a3b8hyyr	2408	8	during	during	IN
cord-006860-a3b8hyyr	2408	9	the	the	DT
cord-006860-a3b8hyyr	2408	10	thromboembolic	thromboembolic	NNP
cord-006860-a3b8hyyr	2408	11	episodes	episode	NNS
cord-006860-a3b8hyyr	2408	12	reflect	reflect	VBP
cord-006860-a3b8hyyr	2408	13	a	a	DT
cord-006860-a3b8hyyr	2408	14	relative	relative	JJ
cord-006860-a3b8hyyr	2408	15	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2408	16	.	.	.
cord-006860-a3b8hyyr	2409	1	From	from	IN
cord-006860-a3b8hyyr	2409	2	a	a	DT
cord-006860-a3b8hyyr	2409	3	clinical	clinical	JJ
cord-006860-a3b8hyyr	2409	4	point	point	NN
cord-006860-a3b8hyyr	2409	5	of	of	IN
cord-006860-a3b8hyyr	2409	6	view	view	NN
cord-006860-a3b8hyyr	2409	7	we	-PRON-	PRP
cord-006860-a3b8hyyr	2409	8	recommend	recommend	VBP
cord-006860-a3b8hyyr	2409	9	the	the	DT
cord-006860-a3b8hyyr	2409	10	use	use	NN
cord-006860-a3b8hyyr	2409	11	of	of	IN
cord-006860-a3b8hyyr	2409	12	a	a	DT
cord-006860-a3b8hyyr	2409	13	lab	lab	NN
cord-006860-a3b8hyyr	2409	14	panel	panel	NN
cord-006860-a3b8hyyr	2409	15	to	to	TO
cord-006860-a3b8hyyr	2409	16	exclude	exclude	VB
cord-006860-a3b8hyyr	2409	17	HAT	hat	NN
cord-006860-a3b8hyyr	2409	18	type	type	NN
cord-006860-a3b8hyyr	2409	19	II	ii	NN
cord-006860-a3b8hyyr	2409	20	in	in	IN
cord-006860-a3b8hyyr	2409	21	patients	patient	NNS
cord-006860-a3b8hyyr	2409	22	with	with	IN
cord-006860-a3b8hyyr	2409	23	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	2409	24	episodes	episode	NNS
cord-006860-a3b8hyyr	2409	25	under	under	IN
cord-006860-a3b8hyyr	2409	26	therapy	therapy	NN
cord-006860-a3b8hyyr	2409	27	with	with	IN
cord-006860-a3b8hyyr	2409	28	fractionated	fractionated	JJ
cord-006860-a3b8hyyr	2409	29	or	or	CC
cord-006860-a3b8hyyr	2409	30	unfractionated	unfractionated	JJ
cord-006860-a3b8hyyr	2409	31	hepafin	hepafin	NN
cord-006860-a3b8hyyr	2409	32	.	.	.
cord-006860-a3b8hyyr	2410	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	2410	2	counts	count	VBZ
cord-006860-a3b8hyyr	2410	3	within	within	IN
cord-006860-a3b8hyyr	2410	4	a	a	DT
cord-006860-a3b8hyyr	2410	5	normal	normal	JJ
cord-006860-a3b8hyyr	2410	6	range	range	NN
cord-006860-a3b8hyyr	2410	7	are	be	VBP
cord-006860-a3b8hyyr	2410	8	no	no	DT
cord-006860-a3b8hyyr	2410	9	absolute	absolute	JJ
cord-006860-a3b8hyyr	2410	10	exclusion	exclusion	NN
cord-006860-a3b8hyyr	2410	11	criterion	criterion	NN
cord-006860-a3b8hyyr	2410	12	for	for	IN
cord-006860-a3b8hyyr	2410	13	HAT	HAT	NNP
cord-006860-a3b8hyyr	2410	14	II	II	NNP
cord-006860-a3b8hyyr	2410	15	.	.	.
cord-006860-a3b8hyyr	2411	1	Low	low	JJ
cord-006860-a3b8hyyr	2411	2	molecular	molecular	JJ
cord-006860-a3b8hyyr	2411	3	weight	weight	NN
cord-006860-a3b8hyyr	2411	4	heparins	heparin	NNS
cord-006860-a3b8hyyr	2411	5	(	(	-LRB-
cord-006860-a3b8hyyr	2411	6	LMWHs	LMWHs	NNP
cord-006860-a3b8hyyr	2411	7	)	)	-RRB-
cord-006860-a3b8hyyr	2411	8	are	be	VBP
cord-006860-a3b8hyyr	2411	9	now	now	RB
cord-006860-a3b8hyyr	2411	10	commonly	commonly	RB
cord-006860-a3b8hyyr	2411	11	used	use	VBN
cord-006860-a3b8hyyr	2411	12	for	for	IN
cord-006860-a3b8hyyr	2411	13	the	the	DT
cord-006860-a3b8hyyr	2411	14	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2411	15	of	of	IN
cord-006860-a3b8hyyr	2411	16	post	post	JJ
cord-006860-a3b8hyyr	2411	17	-	-	JJ
cord-006860-a3b8hyyr	2411	18	surgical	surgical	JJ
cord-006860-a3b8hyyr	2411	19	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	2411	20	complications	complication	NNS
cord-006860-a3b8hyyr	2411	21	.	.	.
cord-006860-a3b8hyyr	2412	1	In	in	IN
cord-006860-a3b8hyyr	2412	2	this	this	DT
cord-006860-a3b8hyyr	2412	3	indication	indication	NN
cord-006860-a3b8hyyr	2412	4	,	,	,
cord-006860-a3b8hyyr	2412	5	LMWHs	LMWHs	NNPS
cord-006860-a3b8hyyr	2412	6	are	be	VBP
cord-006860-a3b8hyyr	2412	7	administered	administer	VBN
cord-006860-a3b8hyyr	2412	8	as	as	IN
cord-006860-a3b8hyyr	2412	9	a	a	DT
cord-006860-a3b8hyyr	2412	10	single	single	JJ
cord-006860-a3b8hyyr	2412	11	or	or	CC
cord-006860-a3b8hyyr	2412	12	twice	twice	PDT
cord-006860-a3b8hyyr	2412	13	a	a	DT
cord-006860-a3b8hyyr	2412	14	day	day	NN
cord-006860-a3b8hyyr	2412	15	subcutaneous	subcutaneous	JJ
cord-006860-a3b8hyyr	2412	16	regimen	regimen	NN
cord-006860-a3b8hyyr	2412	17	.	.	.
cord-006860-a3b8hyyr	2413	1	Usually	usually	RB
cord-006860-a3b8hyyr	2413	2	these	these	DT
cord-006860-a3b8hyyr	2413	3	agents	agent	NNS
cord-006860-a3b8hyyr	2413	4	are	be	VBP
cord-006860-a3b8hyyr	2413	5	administered	administer	VBN
cord-006860-a3b8hyyr	2413	6	at	at	IN
cord-006860-a3b8hyyr	2413	7	30	30	CD
cord-006860-a3b8hyyr	2413	8	-	-	SYM
cord-006860-a3b8hyyr	2413	9	40	40	CD
cord-006860-a3b8hyyr	2413	10	mg	mg	NNP
cord-006860-a3b8hyyr	2413	11	total	total	JJ
cord-006860-a3b8hyyr	2413	12	dose	dose	NN
cord-006860-a3b8hyyr	2413	13	which	which	WDT
cord-006860-a3b8hyyr	2413	14	is	be	VBZ
cord-006860-a3b8hyyr	2413	15	equal	equal	JJ
cord-006860-a3b8hyyr	2413	16	to	to	IN
cord-006860-a3b8hyyr	2413	17	3000	3000	CD
cord-006860-a3b8hyyr	2413	18	-	-	SYM
cord-006860-a3b8hyyr	2413	19	4000	4000	CD
cord-006860-a3b8hyyr	2413	20	anti	anti	JJ
cord-006860-a3b8hyyr	2413	21	-	-	JJ
cord-006860-a3b8hyyr	2413	22	Xa	Xa	NNP
cord-006860-a3b8hyyr	2413	23	(	(	-LRB-
cord-006860-a3b8hyyr	2413	24	AXa	AXa	NNS
cord-006860-a3b8hyyr	2413	25	)	)	-RRB-
cord-006860-a3b8hyyr	2413	26	IU	IU	NNP
cord-006860-a3b8hyyr	2413	27	.	.	.
cord-006860-a3b8hyyr	2414	1	Newer	new	JJR
cord-006860-a3b8hyyr	2414	2	methods	method	NNS
cord-006860-a3b8hyyr	2414	3	such	such	JJ
cord-006860-a3b8hyyr	2414	4	as	as	IN
cord-006860-a3b8hyyr	2414	5	ehromogenic	ehromogenic	NNP
cord-006860-a3b8hyyr	2414	6	substrate	substrate	NN
cord-006860-a3b8hyyr	2414	7	based	base	VBN
cord-006860-a3b8hyyr	2414	8	AXa	AXa	NNP
cord-006860-a3b8hyyr	2414	9	methods	method	NNS
cord-006860-a3b8hyyr	2414	10	and	and	CC
cord-006860-a3b8hyyr	2414	11	the	the	DT
cord-006860-a3b8hyyr	2414	12	heptest	heptest	NN
cord-006860-a3b8hyyr	2414	13	clotting	clotting	NN
cord-006860-a3b8hyyr	2414	14	time	time	NN
cord-006860-a3b8hyyr	2414	15	can	can	MD
cord-006860-a3b8hyyr	2414	16	be	be	VB
cord-006860-a3b8hyyr	2414	17	used	use	VBN
cord-006860-a3b8hyyr	2414	18	to	to	TO
cord-006860-a3b8hyyr	2414	19	determine	determine	VB
cord-006860-a3b8hyyr	2414	20	the	the	DT
cord-006860-a3b8hyyr	2414	21	effects	effect	NNS
cord-006860-a3b8hyyr	2414	22	of	of	IN
cord-006860-a3b8hyyr	2414	23	LMWHs	LMWHs	NNPS
cord-006860-a3b8hyyr	2414	24	during	during	IN
cord-006860-a3b8hyyr	2414	25	the	the	DT
cord-006860-a3b8hyyr	2414	26	initial	initial	JJ
cord-006860-a3b8hyyr	2414	27	phases	phase	NNS
cord-006860-a3b8hyyr	2414	28	of	of	IN
cord-006860-a3b8hyyr	2414	29	prophylactic	prophylactic	JJ
cord-006860-a3b8hyyr	2414	30	therapy	therapy	NN
cord-006860-a3b8hyyr	2414	31	.	.	.
cord-006860-a3b8hyyr	2415	1	This	this	DT
cord-006860-a3b8hyyr	2415	2	may	may	MD
cord-006860-a3b8hyyr	2415	3	be	be	VB
cord-006860-a3b8hyyr	2415	4	useful	useful	JJ
cord-006860-a3b8hyyr	2415	5	in	in	IN
cord-006860-a3b8hyyr	2415	6	the	the	DT
cord-006860-a3b8hyyr	2415	7	elderly	elderly	JJ
cord-006860-a3b8hyyr	2415	8	and	and	CC
cord-006860-a3b8hyyr	2415	9	weight	weight	NN
cord-006860-a3b8hyyr	2415	10	compromised	compromise	VBN
cord-006860-a3b8hyyr	2415	11	patients	patient	NNS
cord-006860-a3b8hyyr	2415	12	where	where	WRB
cord-006860-a3b8hyyr	2415	13	a	a	DT
cord-006860-a3b8hyyr	2415	14	fixed	fix	VBN
cord-006860-a3b8hyyr	2415	15	dosage	dosage	NN
cord-006860-a3b8hyyr	2415	16	may	may	MD
cord-006860-a3b8hyyr	2415	17	not	not	RB
cord-006860-a3b8hyyr	2415	18	be	be	VB
cord-006860-a3b8hyyr	2415	19	optimal	optimal	JJ
cord-006860-a3b8hyyr	2415	20	and	and	CC
cord-006860-a3b8hyyr	2415	21	may	may	MD
cord-006860-a3b8hyyr	2415	22	produce	produce	VB
cord-006860-a3b8hyyr	2415	23	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2415	24	effects	effect	NNS
cord-006860-a3b8hyyr	2415	25	.	.	.
cord-006860-a3b8hyyr	2416	1	Similarly	similarly	RB
cord-006860-a3b8hyyr	2416	2	in	in	IN
cord-006860-a3b8hyyr	2416	3	the	the	DT
cord-006860-a3b8hyyr	2416	4	overweight	overweight	JJ
cord-006860-a3b8hyyr	2416	5	patients	patient	NNS
cord-006860-a3b8hyyr	2416	6	,	,	,
cord-006860-a3b8hyyr	2416	7	a	a	DT
cord-006860-a3b8hyyr	2416	8	fixed	fixed	JJ
cord-006860-a3b8hyyr	2416	9	dose	dose	NN
cord-006860-a3b8hyyr	2416	10	may	may	MD
cord-006860-a3b8hyyr	2416	11	not	not	RB
cord-006860-a3b8hyyr	2416	12	be	be	VB
cord-006860-a3b8hyyr	2416	13	efficacious	efficacious	JJ
cord-006860-a3b8hyyr	2416	14	.	.	.
cord-006860-a3b8hyyr	2417	1	Thus	thus	RB
cord-006860-a3b8hyyr	2417	2	,	,	,
cord-006860-a3b8hyyr	2417	3	monitoring	monitoring	NN
cord-006860-a3b8hyyr	2417	4	of	of	IN
cord-006860-a3b8hyyr	2417	5	LMWHs	LMWHs	NNPS
cord-006860-a3b8hyyr	2417	6	in	in	IN
cord-006860-a3b8hyyr	2417	7	these	these	DT
cord-006860-a3b8hyyr	2417	8	patients	patient	NNS
cord-006860-a3b8hyyr	2417	9	may	may	MD
cord-006860-a3b8hyyr	2417	10	be	be	VB
cord-006860-a3b8hyyr	2417	11	useful	useful	JJ
cord-006860-a3b8hyyr	2417	12	in	in	IN
cord-006860-a3b8hyyr	2417	13	the	the	DT
cord-006860-a3b8hyyr	2417	14	optimization	optimization	NN
cord-006860-a3b8hyyr	2417	15	of	of	IN
cord-006860-a3b8hyyr	2417	16	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2417	17	therapy	therapy	NN
cord-006860-a3b8hyyr	2417	18	.	.	.
cord-006860-a3b8hyyr	2418	1	LMWHs	lmwh	NNS
cord-006860-a3b8hyyr	2418	2	are	be	VBP
cord-006860-a3b8hyyr	2418	3	also	also	RB
cord-006860-a3b8hyyr	2418	4	used	use	VBN
cord-006860-a3b8hyyr	2418	5	in	in	IN
cord-006860-a3b8hyyr	2418	6	the	the	DT
cord-006860-a3b8hyyr	2418	7	treatment	treatment	NN
cord-006860-a3b8hyyr	2418	8	of	of	IN
cord-006860-a3b8hyyr	2418	9	deep	deep	JJ
cord-006860-a3b8hyyr	2418	10	vein	vein	NN
cord-006860-a3b8hyyr	2418	11	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2418	12	using	use	VBG
cord-006860-a3b8hyyr	2418	13	both	both	CC
cord-006860-a3b8hyyr	2418	14	intravenous	intravenous	JJ
cord-006860-a3b8hyyr	2418	15	and	and	CC
cord-006860-a3b8hyyr	2418	16	subcutaneous	subcutaneous	JJ
cord-006860-a3b8hyyr	2418	17	protocols	protocol	NNS
cord-006860-a3b8hyyr	2418	18	.	.	.
cord-006860-a3b8hyyr	2419	1	High	high	JJ
cord-006860-a3b8hyyr	2419	2	dosages	dosage	NNS
cord-006860-a3b8hyyr	2419	3	of	of	IN
cord-006860-a3b8hyyr	2419	4	up	up	IN
cord-006860-a3b8hyyr	2419	5	to	to	TO
cord-006860-a3b8hyyr	2419	6	200	200	CD
cord-006860-a3b8hyyr	2419	7	mg	mg	NNP
cord-006860-a3b8hyyr	2419	8	SC	SC	NNP
cord-006860-a3b8hyyr	2419	9	/	/	SYM
cord-006860-a3b8hyyr	2419	10	day	day	NN
cord-006860-a3b8hyyr	2419	11	and	and	CC
cord-006860-a3b8hyyr	2419	12	infusions	infusion	NNS
cord-006860-a3b8hyyr	2419	13	of	of	IN
cord-006860-a3b8hyyr	2419	14	up	up	IN
cord-006860-a3b8hyyr	2419	15	to	to	TO
cord-006860-a3b8hyyr	2419	16	30	30	CD
cord-006860-a3b8hyyr	2419	17	AXa	AXa	NNS
cord-006860-a3b8hyyr	2419	18	IU	IU	NNP
cord-006860-a3b8hyyr	2419	19	/	/	SYM
cord-006860-a3b8hyyr	2419	20	kg	kg	NNP
cord-006860-a3b8hyyr	2419	21	/	/	SYM
cord-006860-a3b8hyyr	2419	22	hr	hr	NNP
cord-006860-a3b8hyyr	2419	23	have	have	VBP
cord-006860-a3b8hyyr	2419	24	been	be	VBN
cord-006860-a3b8hyyr	2419	25	administered	administer	VBN
cord-006860-a3b8hyyr	2419	26	.	.	.
cord-006860-a3b8hyyr	2420	1	In	in	IN
cord-006860-a3b8hyyr	2420	2	these	these	DT
cord-006860-a3b8hyyr	2420	3	conditions	condition	NNS
cord-006860-a3b8hyyr	2420	4	,	,	,
cord-006860-a3b8hyyr	2420	5	the	the	DT
cord-006860-a3b8hyyr	2420	6	monitoring	monitoring	NN
cord-006860-a3b8hyyr	2420	7	of	of	IN
cord-006860-a3b8hyyr	2420	8	the	the	DT
cord-006860-a3b8hyyr	2420	9	circulating	circulate	VBG
cord-006860-a3b8hyyr	2420	10	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2420	11	levels	level	NNS
cord-006860-a3b8hyyr	2420	12	may	may	MD
cord-006860-a3b8hyyr	2420	13	be	be	VB
cord-006860-a3b8hyyr	2420	14	useful	useful	JJ
cord-006860-a3b8hyyr	2420	15	in	in	IN
cord-006860-a3b8hyyr	2420	16	optimizing	optimize	VBG
cord-006860-a3b8hyyr	2420	17	the	the	DT
cord-006860-a3b8hyyr	2420	18	dosage	dosage	NN
cord-006860-a3b8hyyr	2420	19	.	.	.
cord-006860-a3b8hyyr	2421	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2421	2	have	have	VBP
cord-006860-a3b8hyyr	2421	3	modified	modify	VBN
cord-006860-a3b8hyyr	2421	4	the	the	DT
cord-006860-a3b8hyyr	2421	5	ACA	ACA	NNP
cord-006860-a3b8hyyr	2421	6	heparin	heparin	XX
cord-006860-a3b8hyyr	2422	1	(	(	-LRB-
cord-006860-a3b8hyyr	2422	2	Do_Pont	Do_Pont	NNP
cord-006860-a3b8hyyr	2422	3	Merck	Merck	NNP
cord-006860-a3b8hyyr	2422	4	,	,	,
cord-006860-a3b8hyyr	2422	5	Wilmington	Wilmington	NNP
cord-006860-a3b8hyyr	2422	6	,	,	,
cord-006860-a3b8hyyr	2422	7	DE	DE	NNP
cord-006860-a3b8hyyr	2422	8	)	)	-RRB-
cord-006860-a3b8hyyr	2422	9	method	method	NN
cord-006860-a3b8hyyr	2422	10	to	to	TO
cord-006860-a3b8hyyr	2422	11	measure	measure	VB
cord-006860-a3b8hyyr	2422	12	the	the	DT
cord-006860-a3b8hyyr	2422	13	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2422	14	levels	level	NNS
cord-006860-a3b8hyyr	2422	15	in	in	IN
cord-006860-a3b8hyyr	2422	16	the	the	DT
cord-006860-a3b8hyyr	2422	17	plasma	plasma	NN
cord-006860-a3b8hyyr	2422	18	of	of	IN
cord-006860-a3b8hyyr	2422	19	patients	patient	NNS
cord-006860-a3b8hyyr	2422	20	treated	treat	VBN
cord-006860-a3b8hyyr	2422	21	with	with	IN
cord-006860-a3b8hyyr	2422	22	both	both	CC
cord-006860-a3b8hyyr	2422	23	the	the	DT
cord-006860-a3b8hyyr	2422	24	prophylactic	prophylactic	JJ
cord-006860-a3b8hyyr	2422	25	and	and	CC
cord-006860-a3b8hyyr	2422	26	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	2422	27	dosage	dosage	NN
cord-006860-a3b8hyyr	2422	28	.	.	.
cord-006860-a3b8hyyr	2423	1	Owing	owe	VBG
cord-006860-a3b8hyyr	2423	2	to	to	IN
cord-006860-a3b8hyyr	2423	3	the	the	DT
cord-006860-a3b8hyyr	2423	4	required	require	VBN
cord-006860-a3b8hyyr	2423	5	turnaround	turnaround	NN
cord-006860-a3b8hyyr	2423	6	time	time	NN
cord-006860-a3b8hyyr	2423	7	,	,	,
cord-006860-a3b8hyyr	2423	8	simple	simple	JJ
cord-006860-a3b8hyyr	2423	9	operation	operation	NN
cord-006860-a3b8hyyr	2423	10	and	and	CC
cord-006860-a3b8hyyr	2423	11	reliable	reliable	JJ
cord-006860-a3b8hyyr	2423	12	results	result	NNS
cord-006860-a3b8hyyr	2423	13	,	,	,
cord-006860-a3b8hyyr	2423	14	this	this	DT
cord-006860-a3b8hyyr	2423	15	method	method	NN
cord-006860-a3b8hyyr	2423	16	was	be	VBD
cord-006860-a3b8hyyr	2423	17	found	find	VBN
cord-006860-a3b8hyyr	2423	18	to	to	TO
cord-006860-a3b8hyyr	2423	19	be	be	VB
cord-006860-a3b8hyyr	2423	20	of	of	IN
cord-006860-a3b8hyyr	2423	21	value	value	NN
cord-006860-a3b8hyyr	2423	22	in	in	IN
cord-006860-a3b8hyyr	2423	23	the	the	DT
cord-006860-a3b8hyyr	2423	24	monitoring	monitoring	NN
cord-006860-a3b8hyyr	2423	25	of	of	IN
cord-006860-a3b8hyyr	2423	26	these	these	DT
cord-006860-a3b8hyyr	2423	27	agents	agent	NNS
cord-006860-a3b8hyyr	2423	28	.	.	.
cord-006860-a3b8hyyr	2424	1	This	this	DT
cord-006860-a3b8hyyr	2424	2	presentation	presentation	NN
cord-006860-a3b8hyyr	2424	3	provides	provide	VBZ
cord-006860-a3b8hyyr	2424	4	an	an	DT
cord-006860-a3b8hyyr	2424	5	overview	overview	NN
cord-006860-a3b8hyyr	2424	6	of	of	IN
cord-006860-a3b8hyyr	2424	7	the	the	DT
cord-006860-a3b8hyyr	2424	8	clinical	clinical	JJ
cord-006860-a3b8hyyr	2424	9	application	application	NN
cord-006860-a3b8hyyr	2424	10	of	of	IN
cord-006860-a3b8hyyr	2424	11	various	various	JJ
cord-006860-a3b8hyyr	2424	12	LMWHs	LMWHs	NNPS
cord-006860-a3b8hyyr	2424	13	with	with	IN
cord-006860-a3b8hyyr	2424	14	particular	particular	JJ
cord-006860-a3b8hyyr	2424	15	reference	reference	NN
cord-006860-a3b8hyyr	2424	16	to	to	IN
cord-006860-a3b8hyyr	2424	17	the	the	DT
cord-006860-a3b8hyyr	2424	18	need	need	NN
cord-006860-a3b8hyyr	2424	19	of	of	IN
cord-006860-a3b8hyyr	2424	20	monitoring	monitoring	NN
cord-006860-a3b8hyyr	2424	21	for	for	IN
cord-006860-a3b8hyyr	2424	22	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2424	23	effects	effect	NNS
cord-006860-a3b8hyyr	2424	24	to	to	TO
cord-006860-a3b8hyyr	2424	25	optimize	optimize	VB
cord-006860-a3b8hyyr	2424	26	the	the	DT
cord-006860-a3b8hyyr	2424	27	clinical	clinical	JJ
cord-006860-a3b8hyyr	2424	28	outcome	outcome	NN
cord-006860-a3b8hyyr	2424	29	.	.	.
cord-006860-a3b8hyyr	2425	1	A	a	DT
cord-006860-a3b8hyyr	2425	2	double	double	JJ
cord-006860-a3b8hyyr	2425	3	-	-	HYPH
cord-006860-a3b8hyyr	2425	4	blind	blind	JJ
cord-006860-a3b8hyyr	2425	5	,	,	,
cord-006860-a3b8hyyr	2425	6	multicentric	multicentric	NNP
cord-006860-a3b8hyyr	2425	7	,	,	,
cord-006860-a3b8hyyr	2425	8	controlled	control	VBN
cord-006860-a3b8hyyr	2425	9	trial	trial	NN
cord-006860-a3b8hyyr	2425	10	was	be	VBD
cord-006860-a3b8hyyr	2425	11	performed	perform	VBN
cord-006860-a3b8hyyr	2425	12	in	in	IN
cord-006860-a3b8hyyr	2425	13	order	order	NN
cord-006860-a3b8hyyr	2425	14	to	to	TO
cord-006860-a3b8hyyr	2425	15	compare	compare	VB
cord-006860-a3b8hyyr	2425	16	the	the	DT
cord-006860-a3b8hyyr	2425	17	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	2425	18	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2425	19	and	and	CC
cord-006860-a3b8hyyr	2425	20	safety	safety	NN
cord-006860-a3b8hyyr	2425	21	of	of	IN
cord-006860-a3b8hyyr	2425	22	single	single	JJ
cord-006860-a3b8hyyr	2425	23	daily	daily	JJ
cord-006860-a3b8hyyr	2425	24	doses	dose	NNS
cord-006860-a3b8hyyr	2425	25	of	of	IN
cord-006860-a3b8hyyr	2425	26	5000	5000	CD
cord-006860-a3b8hyyr	2425	27	IE	IE	NNP
cord-006860-a3b8hyyr	2425	28	anti	anti	NNP
cord-006860-a3b8hyyr	2425	29	-	-	NNP
cord-006860-a3b8hyyr	2425	30	Xa	Xa	NNP
cord-006860-a3b8hyyr	2425	31	of	of	IN
cord-006860-a3b8hyyr	2425	32	low	low	JJ
cord-006860-a3b8hyyr	2425	33	molecular	molecular	JJ
cord-006860-a3b8hyyr	2425	34	weight	weight	NN
cord-006860-a3b8hyyr	2425	35	heparin	heparin	NN
cord-006860-a3b8hyyr	2425	36	(	(	-LRB-
cord-006860-a3b8hyyr	2425	37	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2425	38	)	)	-RRB-
cord-006860-a3b8hyyr	2426	1	Sandoz	Sandoz	NNP
cord-006860-a3b8hyyr	2426	2	(	(	-LRB-
cord-006860-a3b8hyyr	2426	3	Certoparin	Certoparin	NNP
cord-006860-a3b8hyyr	2426	4	)	)	-RRB-
cord-006860-a3b8hyyr	2426	5	and	and	CC
cord-006860-a3b8hyyr	2426	6	5000	5000	CD
cord-006860-a3b8hyyr	2426	7	IE	ie	NN
cord-006860-a3b8hyyr	2426	8	unfractionated	unfractionate	VBN
cord-006860-a3b8hyyr	2426	9	heparin	heparin	NN
cord-006860-a3b8hyyr	2426	10	(	(	-LRB-
cord-006860-a3b8hyyr	2426	11	UFH	UFH	NNP
cord-006860-a3b8hyyr	2426	12	)	)	-RRB-
cord-006860-a3b8hyyr	2426	13	tid	tid	XX
cord-006860-a3b8hyyr	2426	14	.	.	.
cord-006860-a3b8hyyr	2427	1	In	in	IN
cord-006860-a3b8hyyr	2427	2	288	288	CD
cord-006860-a3b8hyyr	2427	3	patients	patient	NNS
cord-006860-a3b8hyyr	2427	4	undergoing	undergo	VBG
cord-006860-a3b8hyyr	2427	5	elective	elective	JJ
cord-006860-a3b8hyyr	2427	6	total	total	JJ
cord-006860-a3b8hyyr	2427	7	hip	hip	NN
cord-006860-a3b8hyyr	2427	8	replacement	replacement	NN
cord-006860-a3b8hyyr	2427	9	blood	blood	NN
cord-006860-a3b8hyyr	2427	10	samples	sample	NNS
cord-006860-a3b8hyyr	2427	11	were	be	VBD
cord-006860-a3b8hyyr	2427	12	drawn	draw	VBN
cord-006860-a3b8hyyr	2427	13	before	before	IN
cord-006860-a3b8hyyr	2427	14	the	the	DT
cord-006860-a3b8hyyr	2427	15	first	first	JJ
cord-006860-a3b8hyyr	2427	16	subcutaneous	subcutaneous	JJ
cord-006860-a3b8hyyr	2427	17	injection	injection	NN
cord-006860-a3b8hyyr	2427	18	of	of	IN
cord-006860-a3b8hyyr	2427	19	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2427	20	or	or	CC
cord-006860-a3b8hyyr	2427	21	UFH	UFH	NNP
cord-006860-a3b8hyyr	2427	22	resp	resp	NNP
cord-006860-a3b8hyyr	2427	23	.	.	NNP
cord-006860-a3b8hyyr	2427	24	,	,	,
cord-006860-a3b8hyyr	2427	25	two	two	CD
cord-006860-a3b8hyyr	2427	26	hours	hour	NNS
cord-006860-a3b8hyyr	2427	27	after	after	IN
cord-006860-a3b8hyyr	2427	28	administration	administration	NN
cord-006860-a3b8hyyr	2427	29	on	on	IN
cord-006860-a3b8hyyr	2427	30	the	the	DT
cord-006860-a3b8hyyr	2427	31	first	first	JJ
cord-006860-a3b8hyyr	2427	32	and	and	CC
cord-006860-a3b8hyyr	2427	33	7th	7th	JJ
cord-006860-a3b8hyyr	2427	34	postop	postop	NN
cord-006860-a3b8hyyr	2427	35	,	,	,
cord-006860-a3b8hyyr	2427	36	day	day	NN
cord-006860-a3b8hyyr	2427	37	and	and	CC
cord-006860-a3b8hyyr	2427	38	on	on	IN
cord-006860-a3b8hyyr	2427	39	the	the	DT
cord-006860-a3b8hyyr	2427	40	last	last	JJ
cord-006860-a3b8hyyr	2427	41	day	day	NN
cord-006860-a3b8hyyr	2427	42	of	of	IN
cord-006860-a3b8hyyr	2427	43	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2427	44	(	(	-LRB-
cord-006860-a3b8hyyr	2427	45	day	day	NN
cord-006860-a3b8hyyr	2427	46	10	10	CD
cord-006860-a3b8hyyr	2427	47	-	-	SYM
cord-006860-a3b8hyyr	2427	48	14	14	CD
cord-006860-a3b8hyyr	2427	49	)	)	-RRB-
cord-006860-a3b8hyyr	2427	50	,	,	,
cord-006860-a3b8hyyr	2427	51	Anti	Anti	NNP
cord-006860-a3b8hyyr	2427	52	-	-	NNP
cord-006860-a3b8hyyr	2427	53	Xaactivity	Xaactivity	NNP
cord-006860-a3b8hyyr	2427	54	was	be	VBD
cord-006860-a3b8hyyr	2427	55	measured	measure	VBN
cord-006860-a3b8hyyr	2427	56	by	by	IN
cord-006860-a3b8hyyr	2427	57	chromogenic	chromogenic	NNP
cord-006860-a3b8hyyr	2427	58	substrate	substrate	NN
cord-006860-a3b8hyyr	2427	59	assay	assay	NN
cord-006860-a3b8hyyr	2427	60	,	,	,
cord-006860-a3b8hyyr	2427	61	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2427	62	and	and	CC
cord-006860-a3b8hyyr	2427	63	aPTT	aptt	NN
cord-006860-a3b8hyyr	2427	64	by	by	IN
cord-006860-a3b8hyyr	2427	65	clotting	clot	VBG
cord-006860-a3b8hyyr	2427	66	assays	assay	NNS
cord-006860-a3b8hyyr	2427	67	and	and	CC
cord-006860-a3b8hyyr	2427	68	tissue	tissue	NN
cord-006860-a3b8hyyr	2427	69	factor	factor	NN
cord-006860-a3b8hyyr	2427	70	pathway	pathway	NN
cord-006860-a3b8hyyr	2427	71	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2427	72	(	(	-LRB-
cord-006860-a3b8hyyr	2427	73	TFPI	TFPI	NNP
cord-006860-a3b8hyyr	2427	74	)	)	-RRB-
cord-006860-a3b8hyyr	2427	75	and	and	CC
cord-006860-a3b8hyyr	2427	76	heparin	heparin	NN
cord-006860-a3b8hyyr	2427	77	-	-	HYPH
cord-006860-a3b8hyyr	2427	78	Pf4-antibodies	Pf4-antibodies	NNP
cord-006860-a3b8hyyr	2427	79	by	by	IN
cord-006860-a3b8hyyr	2427	80	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	2427	81	techiques	techique	NNS
cord-006860-a3b8hyyr	2427	82	.	.	.
cord-006860-a3b8hyyr	2428	1	As	as	IN
cord-006860-a3b8hyyr	2428	2	expected	expect	VBN
cord-006860-a3b8hyyr	2428	3	,	,	,
cord-006860-a3b8hyyr	2428	4	the	the	DT
cord-006860-a3b8hyyr	2428	5	anti	anti	JJ
cord-006860-a3b8hyyr	2428	6	-	-	JJ
cord-006860-a3b8hyyr	2428	7	Xa	xa	JJ
cord-006860-a3b8hyyr	2428	8	-	-	HYPH
cord-006860-a3b8hyyr	2428	9	activity	activity	NN
cord-006860-a3b8hyyr	2428	10	and	and	CC
cord-006860-a3b8hyyr	2428	11	the	the	DT
cord-006860-a3b8hyyr	2428	12	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2428	13	values	value	NNS
cord-006860-a3b8hyyr	2428	14	were	be	VBD
cord-006860-a3b8hyyr	2428	15	significantly	significantly	RB
cord-006860-a3b8hyyr	2428	16	higher	high	JJR
cord-006860-a3b8hyyr	2428	17	in	in	IN
cord-006860-a3b8hyyr	2428	18	the	the	DT
cord-006860-a3b8hyyr	2428	19	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2428	20	-	-	HYPH
cord-006860-a3b8hyyr	2428	21	group	group	NN
cord-006860-a3b8hyyr	2428	22	at	at	RB
cord-006860-a3b8hyyr	2428	23	all	all	DT
cord-006860-a3b8hyyr	2428	24	time	time	NN
cord-006860-a3b8hyyr	2428	25	points	point	NNS
cord-006860-a3b8hyyr	2428	26	after	after	IN
cord-006860-a3b8hyyr	2428	27	administration	administration	NN
cord-006860-a3b8hyyr	2428	28	of	of	IN
cord-006860-a3b8hyyr	2428	29	the	the	DT
cord-006860-a3b8hyyr	2428	30	drugs	drug	NNS
cord-006860-a3b8hyyr	2428	31	;	;	:
cord-006860-a3b8hyyr	2428	32	the	the	DT
cord-006860-a3b8hyyr	2428	33	mean	mean	JJ
cord-006860-a3b8hyyr	2428	34	values	value	NNS
cord-006860-a3b8hyyr	2428	35	of	of	IN
cord-006860-a3b8hyyr	2428	36	Heptest	Heptest	NNP
cord-006860-a3b8hyyr	2428	37	were	be	VBD
cord-006860-a3b8hyyr	2428	38	35	35	CD
cord-006860-a3b8hyyr	2428	39	sec	sec	NNS
cord-006860-a3b8hyyr	2428	40	in	in	IN
cord-006860-a3b8hyyr	2428	41	the	the	DT
cord-006860-a3b8hyyr	2428	42	UFH	UFH	NNP
cord-006860-a3b8hyyr	2428	43	-	-	:
cord-006860-a3b8hyyr	2428	44	and	and	CC
cord-006860-a3b8hyyr	2428	45	75	75	CD
cord-006860-a3b8hyyr	2428	46	sec	sec	NNS
cord-006860-a3b8hyyr	2428	47	in	in	IN
cord-006860-a3b8hyyr	2428	48	the	the	DT
cord-006860-a3b8hyyr	2428	49	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2428	50	-	-	HYPH
cord-006860-a3b8hyyr	2428	51	group	group	NN
cord-006860-a3b8hyyr	2428	52	respectively	respectively	RB
cord-006860-a3b8hyyr	2428	53	,	,	,
cord-006860-a3b8hyyr	2428	54	The	the	DT
cord-006860-a3b8hyyr	2428	55	aPTT	aptt	NN
cord-006860-a3b8hyyr	2428	56	was	be	VBD
cord-006860-a3b8hyyr	2428	57	not	not	RB
cord-006860-a3b8hyyr	2428	58	different	different	JJ
cord-006860-a3b8hyyr	2428	59	in	in	IN
cord-006860-a3b8hyyr	2428	60	both	both	DT
cord-006860-a3b8hyyr	2428	61	groups	group	NNS
cord-006860-a3b8hyyr	2428	62	.	.	.
cord-006860-a3b8hyyr	2429	1	At	at	IN
cord-006860-a3b8hyyr	2429	2	the	the	DT
cord-006860-a3b8hyyr	2429	3	end	end	NN
cord-006860-a3b8hyyr	2429	4	of	of	IN
cord-006860-a3b8hyyr	2429	5	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2429	6	positive	positive	JJ
cord-006860-a3b8hyyr	2429	7	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2429	8	to	to	IN
cord-006860-a3b8hyyr	2429	9	heparin	heparin	NN
cord-006860-a3b8hyyr	2429	10	-	-	HYPH
cord-006860-a3b8hyyr	2429	11	Pf4complexes	pf4complexe	NNS
cord-006860-a3b8hyyr	2429	12	were	be	VBD
cord-006860-a3b8hyyr	2429	13	detected	detect	VBN
cord-006860-a3b8hyyr	2429	14	~n	~n	NNP
cord-006860-a3b8hyyr	2429	15	both	both	DT
cord-006860-a3b8hyyr	2429	16	groups	group	NNS
cord-006860-a3b8hyyr	2429	17	;	;	:
cord-006860-a3b8hyyr	2429	18	this	this	DT
cord-006860-a3b8hyyr	2429	19	however	however	RB
cord-006860-a3b8hyyr	2429	20	was	be	VBD
cord-006860-a3b8hyyr	2429	21	not	not	RB
cord-006860-a3b8hyyr	2429	22	correlated	correlate	VBN
cord-006860-a3b8hyyr	2429	23	with	with	IN
cord-006860-a3b8hyyr	2429	24	clinical	clinical	JJ
cord-006860-a3b8hyyr	2429	25	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2429	26	.	.	.
cord-006860-a3b8hyyr	2430	1	A	a	DT
cord-006860-a3b8hyyr	2430	2	detailed	detailed	JJ
cord-006860-a3b8hyyr	2430	3	correlation	correlation	NN
cord-006860-a3b8hyyr	2430	4	between	between	IN
cord-006860-a3b8hyyr	2430	5	patients	patient	NNS
cord-006860-a3b8hyyr	2430	6	with	with	IN
cord-006860-a3b8hyyr	2430	7	deep	deep	JJ
cord-006860-a3b8hyyr	2430	8	vein	vein	NN
cord-006860-a3b8hyyr	2430	9	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2430	10	(	(	-LRB-
cord-006860-a3b8hyyr	2430	11	DVT	DVT	NNP
cord-006860-a3b8hyyr	2430	12	)	)	-RRB-
cord-006860-a3b8hyyr	2430	13	and	and	CC
cord-006860-a3b8hyyr	2430	14	positive	positive	JJ
cord-006860-a3b8hyyr	2430	15	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2430	16	has	have	VBZ
cord-006860-a3b8hyyr	2430	17	still	still	RB
cord-006860-a3b8hyyr	2430	18	to	to	TO
cord-006860-a3b8hyyr	2430	19	be	be	VB
cord-006860-a3b8hyyr	2430	20	done	do	VBN
cord-006860-a3b8hyyr	2430	21	(	(	-LRB-
cord-006860-a3b8hyyr	2430	22	all	all	DT
cord-006860-a3b8hyyr	2430	23	patients	patient	NNS
cord-006860-a3b8hyyr	2430	24	were	be	VBD
cord-006860-a3b8hyyr	2430	25	screened	screen	VBN
cord-006860-a3b8hyyr	2430	26	for	for	IN
cord-006860-a3b8hyyr	2430	27	asymptomatic	asymptomatic	JJ
cord-006860-a3b8hyyr	2430	28	DVT	DVT	NNP
cord-006860-a3b8hyyr	2430	29	between	between	IN
cord-006860-a3b8hyyr	2430	30	day	day	NN
cord-006860-a3b8hyyr	2430	31	10	10	CD
cord-006860-a3b8hyyr	2430	32	-	-	SYM
cord-006860-a3b8hyyr	2430	33	14	14	CD
cord-006860-a3b8hyyr	2430	34	by	by	IN
cord-006860-a3b8hyyr	2430	35	bilateral	bilateral	JJ
cord-006860-a3b8hyyr	2430	36	phlebography	phlebography	NN
cord-006860-a3b8hyyr	2430	37	.	.	.
cord-006860-a3b8hyyr	2431	1	TFPI	TFPI	NNP
cord-006860-a3b8hyyr	2431	2	was	be	VBD
cord-006860-a3b8hyyr	2431	3	markedly	markedly	RB
cord-006860-a3b8hyyr	2431	4	increased	increase	VBN
cord-006860-a3b8hyyr	2431	5	in	in	IN
cord-006860-a3b8hyyr	2431	6	the	the	DT
cord-006860-a3b8hyyr	2431	7	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2431	8	-	-	:
cord-006860-a3b8hyyr	2431	9	and	and	CC
cord-006860-a3b8hyyr	2431	10	only	only	RB
cord-006860-a3b8hyyr	2431	11	slightly	slightly	RB
cord-006860-a3b8hyyr	2431	12	elevated	elevated	JJ
cord-006860-a3b8hyyr	2431	13	in	in	IN
cord-006860-a3b8hyyr	2431	14	the	the	DT
cord-006860-a3b8hyyr	2431	15	UFH	UFH	NNP
cord-006860-a3b8hyyr	2431	16	-	-	HYPH
cord-006860-a3b8hyyr	2431	17	group	group	NN
cord-006860-a3b8hyyr	2431	18	;	;	:
cord-006860-a3b8hyyr	2431	19	the	the	DT
cord-006860-a3b8hyyr	2431	20	differences	difference	NNS
cord-006860-a3b8hyyr	2431	21	are	be	VBP
cord-006860-a3b8hyyr	2431	22	statistically	statistically	RB
cord-006860-a3b8hyyr	2431	23	significant	significant	JJ
cord-006860-a3b8hyyr	2431	24	.	.	.
cord-006860-a3b8hyyr	2432	1	Summarizing	summarize	VBG
cord-006860-a3b8hyyr	2432	2	it	-PRON-	PRP
cord-006860-a3b8hyyr	2432	3	can	can	MD
cord-006860-a3b8hyyr	2432	4	be	be	VB
cord-006860-a3b8hyyr	2432	5	concluded	conclude	VBN
cord-006860-a3b8hyyr	2432	6	that	that	IN
cord-006860-a3b8hyyr	2432	7	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2432	8	to	to	IN
cord-006860-a3b8hyyr	2432	9	heparin	heparin	NN
cord-006860-a3b8hyyr	2432	10	-	-	HYPH
cord-006860-a3b8hyyr	2432	11	Pf4complexes	pf4complexe	NNS
cord-006860-a3b8hyyr	2432	12	may	may	MD
cord-006860-a3b8hyyr	2432	13	occur	occur	VB
cord-006860-a3b8hyyr	2432	14	without	without	IN
cord-006860-a3b8hyyr	2432	15	clinical	clinical	JJ
cord-006860-a3b8hyyr	2432	16	symptoms	symptom	NNS
cord-006860-a3b8hyyr	2432	17	of	of	IN
cord-006860-a3b8hyyr	2432	18	hepafin	hepafin	NN
cord-006860-a3b8hyyr	2432	19	-	-	HYPH
cord-006860-a3b8hyyr	2432	20	induced	induce	VBN
cord-006860-a3b8hyyr	2432	21	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2432	22	type	type	NN
cord-006860-a3b8hyyr	2432	23	II	II	NNP
cord-006860-a3b8hyyr	2432	24	and	and	CC
cord-006860-a3b8hyyr	2432	25	that	that	IN
cord-006860-a3b8hyyr	2432	26	TFPI	TFPI	NNP
cord-006860-a3b8hyyr	2432	27	may	may	MD
cord-006860-a3b8hyyr	2432	28	play	play	VB
cord-006860-a3b8hyyr	2432	29	a	a	DT
cord-006860-a3b8hyyr	2432	30	sigificant	sigificant	JJ
cord-006860-a3b8hyyr	2432	31	role	role	NN
cord-006860-a3b8hyyr	2432	32	for	for	IN
cord-006860-a3b8hyyr	2432	33	the	the	DT
cord-006860-a3b8hyyr	2432	34	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	2432	35	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2432	36	of	of	IN
cord-006860-a3b8hyyr	2432	37	UFH	UFH	NNP
cord-006860-a3b8hyyr	2432	38	and	and	CC
cord-006860-a3b8hyyr	2432	39	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2432	40	.	.	.
cord-006860-a3b8hyyr	2433	1	Unfractienated	unfractienated	JJ
cord-006860-a3b8hyyr	2433	2	heparin	heparin	NN
cord-006860-a3b8hyyr	2433	3	represents	represent	VBZ
cord-006860-a3b8hyyr	2433	4	one	one	CD
cord-006860-a3b8hyyr	2433	5	of	of	IN
cord-006860-a3b8hyyr	2433	6	the	the	DT
cord-006860-a3b8hyyr	2433	7	most	most	RBS
cord-006860-a3b8hyyr	2433	8	severe	severe	JJ
cord-006860-a3b8hyyr	2433	9	and	and	CC
cord-006860-a3b8hyyr	2433	10	frequent	frequent	JJ
cord-006860-a3b8hyyr	2433	11	causes	cause	NNS
cord-006860-a3b8hyyr	2433	12	of	of	IN
cord-006860-a3b8hyyr	2433	13	drug	drug	NN
cord-006860-a3b8hyyr	2433	14	-	-	HYPH
cord-006860-a3b8hyyr	2433	15	induced	induce	VBN
cord-006860-a3b8hyyr	2433	16	thrombooytopenia	thrombooytopenia	NN
cord-006860-a3b8hyyr	2433	17	.	.	.
cord-006860-a3b8hyyr	2434	1	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	2434	2	-	-	HYPH
cord-006860-a3b8hyyr	2434	3	indueed	indueed	NN
cord-006860-a3b8hyyr	2434	4	thrombocytopeala	thrombocytopeala	NNP
cord-006860-a3b8hyyr	2434	5	(	(	-LRB-
cord-006860-a3b8hyyr	2434	6	HIT	HIT	NNP
cord-006860-a3b8hyyr	2434	7	)	)	-RRB-
cord-006860-a3b8hyyr	2435	1	occurring	occur	VBG
cord-006860-a3b8hyyr	2435	2	early	early	RB
cord-006860-a3b8hyyr	2435	3	in	in	IN
cord-006860-a3b8hyyr	2435	4	therapy	therapy	NN
cord-006860-a3b8hyyr	2435	5	is	be	VBZ
cord-006860-a3b8hyyr	2435	6	often	often	RB
cord-006860-a3b8hyyr	2435	7	mild	mild	JJ
cord-006860-a3b8hyyr	2435	8	and	and	CC
cord-006860-a3b8hyyr	2435	9	serf	serf	NN
cord-006860-a3b8hyyr	2435	10	-	-	HYPH
cord-006860-a3b8hyyr	2435	11	limited	limited	JJ
cord-006860-a3b8hyyr	2435	12	,	,	,
cord-006860-a3b8hyyr	2435	13	appearing	appear	VBG
cord-006860-a3b8hyyr	2435	14	to	to	TO
cord-006860-a3b8hyyr	2435	15	be	be	VB
cord-006860-a3b8hyyr	2435	16	caused	cause	VBN
cord-006860-a3b8hyyr	2435	17	by	by	IN
cord-006860-a3b8hyyr	2435	18	a	a	DT
cord-006860-a3b8hyyr	2435	19	direct	direct	JJ
cord-006860-a3b8hyyr	2435	20	aggregant	aggregant	JJ
cord-006860-a3b8hyyr	2435	21	effect	effect	NN
cord-006860-a3b8hyyr	2435	22	of	of	IN
cord-006860-a3b8hyyr	2435	23	heparin	heparin	NN
cord-006860-a3b8hyyr	2435	24	on	on	IN
cord-006860-a3b8hyyr	2435	25	platelets	platelet	NNS
cord-006860-a3b8hyyr	2435	26	(	(	-LRB-
cord-006860-a3b8hyyr	2435	27	HIT	HIT	VBN
cord-006860-a3b8hyyr	2435	28	type	type	NN
cord-006860-a3b8hyyr	2435	29	I	i	NN
cord-006860-a3b8hyyr	2435	30	)	)	-RRB-
cord-006860-a3b8hyyr	2435	31	.	.	.
cord-006860-a3b8hyyr	2436	1	HIT	hit	NN
cord-006860-a3b8hyyr	2436	2	type	type	NN
cord-006860-a3b8hyyr	2436	3	II	ii	NN
cord-006860-a3b8hyyr	2436	4	,	,	,
cord-006860-a3b8hyyr	2436	5	however	however	RB
cord-006860-a3b8hyyr	2436	6	,	,	,
cord-006860-a3b8hyyr	2436	7	is	be	VBZ
cord-006860-a3b8hyyr	2436	8	immune	immune	NN
cord-006860-a3b8hyyr	2436	9	-	-	HYPH
cord-006860-a3b8hyyr	2436	10	related	relate	VBN
cord-006860-a3b8hyyr	2436	11	an	an	DT
cord-006860-a3b8hyyr	2436	12	may	may	MD
cord-006860-a3b8hyyr	2436	13	result	result	VB
cord-006860-a3b8hyyr	2436	14	in	in	IN
cord-006860-a3b8hyyr	2436	15	absolute	absolute	JJ
cord-006860-a3b8hyyr	2436	16	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2437	1	(	(	-LRB-
cord-006860-a3b8hyyr	2437	2	platelet	platelet	NN
cord-006860-a3b8hyyr	2437	3	count	count	NN
cord-006860-a3b8hyyr	2437	4	<	<	XX
cord-006860-a3b8hyyr	2437	5	I50/~L	I50/~L	NNP
cord-006860-a3b8hyyr	2437	6	)	)	-RRB-
cord-006860-a3b8hyyr	2437	7	or	or	CC
cord-006860-a3b8hyyr	2437	8	a	a	DT
cord-006860-a3b8hyyr	2437	9	relative	relative	JJ
cord-006860-a3b8hyyr	2437	10	decrease	decrease	NN
cord-006860-a3b8hyyr	2437	11	in	in	IN
cord-006860-a3b8hyyr	2437	12	platelet	platelet	NN
cord-006860-a3b8hyyr	2437	13	count	count	NN
cord-006860-a3b8hyyr	2437	14	(	(	-LRB-
cord-006860-a3b8hyyr	2437	15	?	?	.
cord-006860-a3b8hyyr	2438	1	_	_	NN
cord-006860-a3b8hyyr	2438	2	50	50	CD
cord-006860-a3b8hyyr	2438	3	%	%	NN
cord-006860-a3b8hyyr	2438	4	reduction	reduction	NN
cord-006860-a3b8hyyr	2438	5	from	from	IN
cord-006860-a3b8hyyr	2438	6	baseline	baseline	JJ
cord-006860-a3b8hyyr	2438	7	values	value	NNS
cord-006860-a3b8hyyr	2438	8	)	)	-RRB-
cord-006860-a3b8hyyr	2438	9	.	.	.
cord-006860-a3b8hyyr	2439	1	Unlike	unlike	IN
cord-006860-a3b8hyyr	2439	2	most	most	JJS
cord-006860-a3b8hyyr	2439	3	other	other	JJ
cord-006860-a3b8hyyr	2439	4	immune	immune	JJ
cord-006860-a3b8hyyr	2439	5	thrombecytopenias	thrombecytopenia	NNS
cord-006860-a3b8hyyr	2439	6	in	in	IN
cord-006860-a3b8hyyr	2439	7	which	which	WDT
cord-006860-a3b8hyyr	2439	8	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2439	9	complications	complication	NNS
cord-006860-a3b8hyyr	2439	10	often	often	RB
cord-006860-a3b8hyyr	2439	11	predominate	predominate	VBP
cord-006860-a3b8hyyr	2439	12	,	,	,
cord-006860-a3b8hyyr	2439	13	HIT	hit	VB
cord-006860-a3b8hyyr	2439	14	type	type	NN
cord-006860-a3b8hyyr	2439	15	II	II	NNP
cord-006860-a3b8hyyr	2439	16	may	may	MD
cord-006860-a3b8hyyr	2439	17	results	result	VBZ
cord-006860-a3b8hyyr	2439	18	in	in	IN
cord-006860-a3b8hyyr	2439	19	severe	severe	JJ
cord-006860-a3b8hyyr	2439	20	arterial	arterial	NN
cord-006860-a3b8hyyr	2439	21	and/or	and/or	CC
cord-006860-a3b8hyyr	2439	22	venous	venous	JJ
cord-006860-a3b8hyyr	2439	23	thromboses	thrombose	NNS
cord-006860-a3b8hyyr	2439	24	.	.	.
cord-006860-a3b8hyyr	2440	1	The	the	DT
cord-006860-a3b8hyyr	2440	2	management	management	NN
cord-006860-a3b8hyyr	2440	3	of	of	IN
cord-006860-a3b8hyyr	2440	4	patients	patient	NNS
cord-006860-a3b8hyyr	2440	5	with	with	IN
cord-006860-a3b8hyyr	2440	6	HIT	hit	NN
cord-006860-a3b8hyyr	2440	7	type	type	NN
cord-006860-a3b8hyyr	2440	8	II	ii	NN
cord-006860-a3b8hyyr	2440	9	and	and	CC
cord-006860-a3b8hyyr	2440	10	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2440	11	is	be	VBZ
cord-006860-a3b8hyyr	2440	12	often	often	RB
cord-006860-a3b8hyyr	2440	13	difficult	difficult	JJ
cord-006860-a3b8hyyr	2440	14	.	.	.
cord-006860-a3b8hyyr	2441	1	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	2441	2	must	must	MD
cord-006860-a3b8hyyr	2441	3	be	be	VB
cord-006860-a3b8hyyr	2441	4	stopped	stop	VBN
cord-006860-a3b8hyyr	2441	5	immediately	immediately	RB
cord-006860-a3b8hyyr	2441	6	.	.	.
cord-006860-a3b8hyyr	2442	1	Antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	2442	2	,	,	,
cord-006860-a3b8hyyr	2442	3	fibfinolytic	fibfinolytic	JJ
cord-006860-a3b8hyyr	2442	4	,	,	,
cord-006860-a3b8hyyr	2442	5	or	or	CC
cord-006860-a3b8hyyr	2442	6	antiplatelet	antiplatelet	NN
cord-006860-a3b8hyyr	2442	7	agents	agent	NNS
cord-006860-a3b8hyyr	2442	8	have	have	VBP
cord-006860-a3b8hyyr	2442	9	been	be	VBN
cord-006860-a3b8hyyr	2442	10	used	use	VBN
cord-006860-a3b8hyyr	2442	11	in	in	IN
cord-006860-a3b8hyyr	2442	12	these	these	DT
cord-006860-a3b8hyyr	2442	13	situations	situation	NNS
cord-006860-a3b8hyyr	2442	14	,	,	,
cord-006860-a3b8hyyr	2442	15	as	as	IN
cord-006860-a3b8hyyr	2442	16	have	have	VBP
cord-006860-a3b8hyyr	2442	17	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	2442	18	other	other	JJ
cord-006860-a3b8hyyr	2442	19	than	than	IN
cord-006860-a3b8hyyr	2442	20	unfraetionated	unfraetionate	VBN
cord-006860-a3b8hyyr	2442	21	hepafirL	hepafirL	NNP
cord-006860-a3b8hyyr	2442	22	Plasmapheresis	Plasmapheresis	NNP
cord-006860-a3b8hyyr	2442	23	,	,	,
cord-006860-a3b8hyyr	2442	24	used	use	VBN
cord-006860-a3b8hyyr	2442	25	in	in	IN
cord-006860-a3b8hyyr	2442	26	other	other	JJ
cord-006860-a3b8hyyr	2442	27	immune	immune	NN
cord-006860-a3b8hyyr	2442	28	-	-	HYPH
cord-006860-a3b8hyyr	2442	29	related	relate	VBN
cord-006860-a3b8hyyr	2442	30	disorders	disorder	NNS
cord-006860-a3b8hyyr	2442	31	,	,	,
cord-006860-a3b8hyyr	2442	32	has	have	VBZ
cord-006860-a3b8hyyr	2442	33	also	also	RB
cord-006860-a3b8hyyr	2442	34	been	be	VBN
cord-006860-a3b8hyyr	2442	35	occasionally	occasionally	RB
cord-006860-a3b8hyyr	2442	36	reported	report	VBN
cord-006860-a3b8hyyr	2442	37	.	.	.
cord-006860-a3b8hyyr	2443	1	At	at	IN
cord-006860-a3b8hyyr	2443	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2443	3	institution	institution	NN
cord-006860-a3b8hyyr	2443	4	this	this	DT
cord-006860-a3b8hyyr	2443	5	intervention	intervention	NN
cord-006860-a3b8hyyr	2443	6	appears	appear	VBZ
cord-006860-a3b8hyyr	2443	7	to	to	TO
cord-006860-a3b8hyyr	2443	8	provide	provide	VB
cord-006860-a3b8hyyr	2443	9	significant	significant	JJ
cord-006860-a3b8hyyr	2443	10	elininal	elininal	JJ
cord-006860-a3b8hyyr	2443	11	benefit	benefit	NN
cord-006860-a3b8hyyr	2443	12	to	to	TO
cord-006860-a3b8hyyr	2443	13	HIT	hit	VB
cord-006860-a3b8hyyr	2443	14	patients	patient	NNS
cord-006860-a3b8hyyr	2443	15	.	.	.
cord-006860-a3b8hyyr	2444	1	Several	several	JJ
cord-006860-a3b8hyyr	2444	2	recent	recent	JJ
cord-006860-a3b8hyyr	2444	3	reports	report	NNS
cord-006860-a3b8hyyr	2444	4	have	have	VBP
cord-006860-a3b8hyyr	2444	5	noted	note	VBN
cord-006860-a3b8hyyr	2444	6	that	that	IN
cord-006860-a3b8hyyr	2444	7	the	the	DT
cord-006860-a3b8hyyr	2444	8	heparin	heparin	NN
cord-006860-a3b8hyyr	2444	9	-	-	HYPH
cord-006860-a3b8hyyr	2444	10	dependent	dependent	JJ
cord-006860-a3b8hyyr	2444	11	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2444	12	in	in	IN
cord-006860-a3b8hyyr	2444	13	HIT	hit	NN
cord-006860-a3b8hyyr	2444	14	type	type	NN
cord-006860-a3b8hyyr	2444	15	II	II	NNP
cord-006860-a3b8hyyr	2444	16	are	be	VBP
cord-006860-a3b8hyyr	2444	17	directed	direct	VBN
cord-006860-a3b8hyyr	2444	18	against	against	IN
cord-006860-a3b8hyyr	2444	19	a	a	DT
cord-006860-a3b8hyyr	2444	20	complex	complex	NN
cord-006860-a3b8hyyr	2444	21	of	of	IN
cord-006860-a3b8hyyr	2444	22	heparin	heparin	NN
cord-006860-a3b8hyyr	2444	23	bound	bind	VBN
cord-006860-a3b8hyyr	2444	24	to	to	IN
cord-006860-a3b8hyyr	2444	25	platelet	platelet	NN
cord-006860-a3b8hyyr	2444	26	factor	factor	NN
cord-006860-a3b8hyyr	2444	27	4	4	CD
cord-006860-a3b8hyyr	2444	28	(	(	-LRB-
cord-006860-a3b8hyyr	2444	29	PF4	PF4	NNP
cord-006860-a3b8hyyr	2444	30	)	)	-RRB-
cord-006860-a3b8hyyr	2444	31	and	and	CC
cord-006860-a3b8hyyr	2444	32	an	an	DT
cord-006860-a3b8hyyr	2444	33	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	2444	34	-	-	HYPH
cord-006860-a3b8hyyr	2444	35	based	base	VBN
cord-006860-a3b8hyyr	2444	36	test	test	NN
cord-006860-a3b8hyyr	2444	37	system	system	NN
cord-006860-a3b8hyyr	2444	38	for	for	IN
cord-006860-a3b8hyyr	2444	39	hepafin	hepafin	NN
cord-006860-a3b8hyyr	2444	40	-	-	HYPH
cord-006860-a3b8hyyr	2444	41	PF4	pf4	JJ
cord-006860-a3b8hyyr	2444	42	eomplexinduced	eomplexinduced	JJ
cord-006860-a3b8hyyr	2444	43	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2444	44	(	(	-LRB-
cord-006860-a3b8hyyr	2444	45	HPIA	HPIA	NNP
cord-006860-a3b8hyyr	2444	46	;	;	:
cord-006860-a3b8hyyr	2444	47	Stago	Stago	NNP
cord-006860-a3b8hyyr	2444	48	)	)	-RRB-
cord-006860-a3b8hyyr	2444	49	has	have	VBZ
cord-006860-a3b8hyyr	2444	50	been	be	VBN
cord-006860-a3b8hyyr	2444	51	develuped~	develuped~	NNP
cord-006860-a3b8hyyr	2445	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2445	2	report	report	VBP
cord-006860-a3b8hyyr	2445	3	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2445	4	experience	experience	NN
cord-006860-a3b8hyyr	2445	5	in	in	IN
cord-006860-a3b8hyyr	2445	6	3	3	CD
cord-006860-a3b8hyyr	2445	7	patients	patient	NNS
cord-006860-a3b8hyyr	2445	8	with	with	IN
cord-006860-a3b8hyyr	2445	9	HIT	hit	NN
cord-006860-a3b8hyyr	2445	10	type	type	NN
cord-006860-a3b8hyyr	2445	11	II	ii	NN
cord-006860-a3b8hyyr	2445	12	in	in	IN
cord-006860-a3b8hyyr	2445	13	whom	whom	WP
cord-006860-a3b8hyyr	2445	14	plasmapheresis	plasmapheresis	NN
cord-006860-a3b8hyyr	2445	15	was	be	VBD
cord-006860-a3b8hyyr	2445	16	instituted	institute	VBN
cord-006860-a3b8hyyr	2445	17	and	and	CC
cord-006860-a3b8hyyr	2446	1	the	the	DT
cord-006860-a3b8hyyr	2446	2	antibody	antibody	NN
cord-006860-a3b8hyyr	2446	3	levels	level	NNS
cord-006860-a3b8hyyr	2446	4	in	in	IN
cord-006860-a3b8hyyr	2446	5	blood	blood	NN
cord-006860-a3b8hyyr	2446	6	were	be	VBD
cord-006860-a3b8hyyr	2446	7	measured	measure	VBN
cord-006860-a3b8hyyr	2446	8	pre	pre	JJ
cord-006860-a3b8hyyr	2446	9	-	-	HYPH
cord-006860-a3b8hyyr	2446	10	and	and	CC
cord-006860-a3b8hyyr	2446	11	post	post	JJ
cord-006860-a3b8hyyr	2446	12	-	-	NN
cord-006860-a3b8hyyr	2446	13	treatment	treatment	NN
cord-006860-a3b8hyyr	2446	14	to	to	TO
cord-006860-a3b8hyyr	2446	15	identify	identify	VB
cord-006860-a3b8hyyr	2446	16	wkether	wkether	NNP
cord-006860-a3b8hyyr	2446	17	circulating	circulate	VBG
cord-006860-a3b8hyyr	2446	18	antibody	antibody	NN
cord-006860-a3b8hyyr	2446	19	titers	titer	NNS
cord-006860-a3b8hyyr	2446	20	decreased	decrease	VBD
cord-006860-a3b8hyyr	2446	21	thus	thus	RB
cord-006860-a3b8hyyr	2446	22	providing	provide	VBG
cord-006860-a3b8hyyr	2446	23	some	some	DT
cord-006860-a3b8hyyr	2446	24	explanation	explanation	NN
cord-006860-a3b8hyyr	2446	25	for	for	IN
cord-006860-a3b8hyyr	2446	26	the	the	DT
cord-006860-a3b8hyyr	2446	27	clinical	clinical	JJ
cord-006860-a3b8hyyr	2446	28	benefit	benefit	NN
cord-006860-a3b8hyyr	2446	29	.	.	.
cord-006860-a3b8hyyr	2447	1	The	the	DT
cord-006860-a3b8hyyr	2447	2	patients	patient	NNS
cord-006860-a3b8hyyr	2447	3	developed	develop	VBD
cord-006860-a3b8hyyr	2447	4	profound	profound	JJ
cord-006860-a3b8hyyr	2447	5	absolute	absolute	JJ
cord-006860-a3b8hyyr	2447	6	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2447	7	(	(	-LRB-
cord-006860-a3b8hyyr	2447	8	range	range	NN
cord-006860-a3b8hyyr	2447	9	,	,	,
cord-006860-a3b8hyyr	2447	10	3	3	CD
cord-006860-a3b8hyyr	2447	11	-	-	SYM
cord-006860-a3b8hyyr	2447	12	21	21	CD
cord-006860-a3b8hyyr	2447	13	K/~tL	k/~tl	NN
cord-006860-a3b8hyyr	2447	14	)	)	-RRB-
cord-006860-a3b8hyyr	2447	15	and	and	CC
cord-006860-a3b8hyyr	2447	16	positive	positive	JJ
cord-006860-a3b8hyyr	2447	17	heparin	heparin	NN
cord-006860-a3b8hyyr	2447	18	-	-	HYPH
cord-006860-a3b8hyyr	2447	19	induced	induce	VBN
cord-006860-a3b8hyyr	2447	20	platetet	platetet	NNP
cord-006860-a3b8hyyr	2447	21	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2447	22	studies	study	NNS
cord-006860-a3b8hyyr	2447	23	following	follow	VBG
cord-006860-a3b8hyyr	2447	24	treamlent	treamlent	NNP
cord-006860-a3b8hyyr	2447	25	with	with	IN
cord-006860-a3b8hyyr	2447	26	uofractionated	uofractionate	VBN
cord-006860-a3b8hyyr	2447	27	heparin	heparin	NNP
cord-006860-a3b8hyyr	2447	28	.	.	.
cord-006860-a3b8hyyr	2448	1	Thromh0cytopenia	Thromh0cytopenia	NNP
cord-006860-a3b8hyyr	2449	1	induced	induce	VBN
cord-006860-a3b8hyyr	2449	2	by	by	IN
cord-006860-a3b8hyyr	2449	3	hepariu	hepariu	NNP
cord-006860-a3b8hyyr	2449	4	(	(	-LRB-
cord-006860-a3b8hyyr	2449	5	HAT	HAT	NNP
cord-006860-a3b8hyyr	2449	6	-	-	HYPH
cord-006860-a3b8hyyr	2449	7	Syndrome	Syndrome	NNP
cord-006860-a3b8hyyr	2449	8	)	)	-RRB-
cord-006860-a3b8hyyr	2449	9	typically	typically	RB
cord-006860-a3b8hyyr	2449	10	appears	appear	VBZ
cord-006860-a3b8hyyr	2449	11	several	several	JJ
cord-006860-a3b8hyyr	2449	12	days	day	NNS
cord-006860-a3b8hyyr	2449	13	after	after	IN
cord-006860-a3b8hyyr	2449	14	initiation	initiation	NN
cord-006860-a3b8hyyr	2449	15	of	of	IN
cord-006860-a3b8hyyr	2449	16	heparin	heparin	NN
cord-006860-a3b8hyyr	2449	17	therapy	therapy	NN
cord-006860-a3b8hyyr	2449	18	.	.	.
cord-006860-a3b8hyyr	2450	1	This	this	DT
cord-006860-a3b8hyyr	2450	2	phenomenon	phenomenon	NN
cord-006860-a3b8hyyr	2450	3	is	be	VBZ
cord-006860-a3b8hyyr	2450	4	caused	cause	VBN
cord-006860-a3b8hyyr	2450	5	by	by	IN
cord-006860-a3b8hyyr	2450	6	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2450	7	of	of	IN
cord-006860-a3b8hyyr	2450	8	the	the	DT
cord-006860-a3b8hyyr	2450	9	lgG	lgG	NNP
cord-006860-a3b8hyyr	2450	10	type	type	NN
cord-006860-a3b8hyyr	2450	11	which	which	WDT
cord-006860-a3b8hyyr	2450	12	are	be	VBP
cord-006860-a3b8hyyr	2450	13	induced	induce	VBN
cord-006860-a3b8hyyr	2450	14	by	by	IN
cord-006860-a3b8hyyr	2450	15	a	a	DT
cord-006860-a3b8hyyr	2450	16	heparin	heparin	NN
cord-006860-a3b8hyyr	2450	17	-	-	HYPH
cord-006860-a3b8hyyr	2450	18	PF	pf	NN
cord-006860-a3b8hyyr	2450	19	4-complex	4-complex	CD
cord-006860-a3b8hyyr	2450	20	and	and	CC
cord-006860-a3b8hyyr	2450	21	which	which	WDT
cord-006860-a3b8hyyr	2450	22	also	also	RB
cord-006860-a3b8hyyr	2450	23	activate	activate	VBP
cord-006860-a3b8hyyr	2450	24	platelets	platelet	NNS
cord-006860-a3b8hyyr	2450	25	.	.	.
cord-006860-a3b8hyyr	2451	1	In	in	IN
cord-006860-a3b8hyyr	2451	2	a	a	DT
cord-006860-a3b8hyyr	2451	3	recent	recent	JJ
cord-006860-a3b8hyyr	2451	4	study	study	NN
cord-006860-a3b8hyyr	2451	5	(	(	-LRB-
cord-006860-a3b8hyyr	2451	6	N	N	NNP
cord-006860-a3b8hyyr	2451	7	Engl	Engl	NNP
cord-006860-a3b8hyyr	2451	8	J	J	NNP
cord-006860-a3b8hyyr	2451	9	Med	Med	NNP
cord-006860-a3b8hyyr	2451	10	1995	1995	CD
cord-006860-a3b8hyyr	2451	11	;	;	:
cord-006860-a3b8hyyr	2451	12	332:1330	332:1330	NNP
cord-006860-a3b8hyyr	2451	13	-	-	HYPH
cord-006860-a3b8hyyr	2451	14	5	5	LS
cord-006860-a3b8hyyr	2451	15	)	)	-RRB-
cord-006860-a3b8hyyr	2451	16	the	the	DT
cord-006860-a3b8hyyr	2451	17	HAT	HAT	NNP
cord-006860-a3b8hyyr	2451	18	-	-	HYPH
cord-006860-a3b8hyyr	2451	19	Syndrom	Syndrom	NNP
cord-006860-a3b8hyyr	2451	20	was	be	VBD
cord-006860-a3b8hyyr	2451	21	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	2451	22	in	in	IN
cord-006860-a3b8hyyr	2451	23	2.7	2.7	CD
cord-006860-a3b8hyyr	2451	24	%	%	NN
cord-006860-a3b8hyyr	2451	25	(	(	-LRB-
cord-006860-a3b8hyyr	2451	26	9	9	CD
cord-006860-a3b8hyyr	2451	27	of	of	IN
cord-006860-a3b8hyyr	2451	28	332	332	CD
cord-006860-a3b8hyyr	2451	29	)	)	-RRB-
cord-006860-a3b8hyyr	2451	30	patients	patient	NNS
cord-006860-a3b8hyyr	2451	31	who	who	WP
cord-006860-a3b8hyyr	2451	32	had	have	VBD
cord-006860-a3b8hyyr	2451	33	received	receive	VBN
cord-006860-a3b8hyyr	2451	34	unfractionated	unfractionated	JJ
cord-006860-a3b8hyyr	2451	35	heparin	heparin	NN
cord-006860-a3b8hyyr	2451	36	(	(	-LRB-
cord-006860-a3b8hyyr	2451	37	UFH	UFH	NNP
cord-006860-a3b8hyyr	2451	38	)	)	-RRB-
cord-006860-a3b8hyyr	2451	39	and	and	CC
cord-006860-a3b8hyyr	2451	40	in	in	IN
cord-006860-a3b8hyyr	2451	41	none	none	NN
cord-006860-a3b8hyyr	2451	42	of	of	IN
cord-006860-a3b8hyyr	2451	43	those	those	DT
cord-006860-a3b8hyyr	2451	44	333	333	CD
cord-006860-a3b8hyyr	2451	45	patients	patient	NNS
cord-006860-a3b8hyyr	2451	46	who	who	WP
cord-006860-a3b8hyyr	2451	47	had	have	VBD
cord-006860-a3b8hyyr	2451	48	been	be	VBN
cord-006860-a3b8hyyr	2451	49	treated	treat	VBN
cord-006860-a3b8hyyr	2451	50	with	with	IN
cord-006860-a3b8hyyr	2451	51	low	low	JJ
cord-006860-a3b8hyyr	2451	52	-	-	HYPH
cord-006860-a3b8hyyr	2451	53	molecular	molecular	JJ
cord-006860-a3b8hyyr	2451	54	-	-	HYPH
cord-006860-a3b8hyyr	2451	55	weight	weight	NN
cord-006860-a3b8hyyr	2451	56	heparin	heparin	NN
cord-006860-a3b8hyyr	2451	57	(	(	-LRB-
cord-006860-a3b8hyyr	2451	58	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2451	59	)	)	-RRB-
cord-006860-a3b8hyyr	2451	60	.	.	.
cord-006860-a3b8hyyr	2452	1	8	8	CD
cord-006860-a3b8hyyr	2452	2	out	out	IN
cord-006860-a3b8hyyr	2452	3	of	of	IN
cord-006860-a3b8hyyr	2452	4	the	the	DT
cord-006860-a3b8hyyr	2452	5	9	9	CD
cord-006860-a3b8hyyr	2452	6	patients	patient	NNS
cord-006860-a3b8hyyr	2452	7	treated	treat	VBN
cord-006860-a3b8hyyr	2452	8	with	with	IN
cord-006860-a3b8hyyr	2452	9	UFH	UFH	NNP
cord-006860-a3b8hyyr	2452	10	presented	present	VBN
cord-006860-a3b8hyyr	2452	11	with	with	IN
cord-006860-a3b8hyyr	2452	12	at	at	RB
cord-006860-a3b8hyyr	2452	13	least	least	RBS
cord-006860-a3b8hyyr	2452	14	one	one	CD
cord-006860-a3b8hyyr	2452	15	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	2452	16	event	event	NN
cord-006860-a3b8hyyr	2452	17	(	(	-LRB-
cord-006860-a3b8hyyr	2452	18	7	7	CD
cord-006860-a3b8hyyr	2452	19	times	time	NNS
cord-006860-a3b8hyyr	2452	20	a	a	DT
cord-006860-a3b8hyyr	2452	21	venous	venous	NN
cord-006860-a3b8hyyr	2452	22	,	,	,
cord-006860-a3b8hyyr	2452	23	once	once	RB
cord-006860-a3b8hyyr	2452	24	an	an	DT
cord-006860-a3b8hyyr	2452	25	arterial	arterial	JJ
cord-006860-a3b8hyyr	2452	26	event	event	NN
cord-006860-a3b8hyyr	2452	27	)	)	-RRB-
cord-006860-a3b8hyyr	2452	28	.	.	.
cord-006860-a3b8hyyr	2453	1	The	the	DT
cord-006860-a3b8hyyr	2453	2	incidence	incidence	NN
cord-006860-a3b8hyyr	2453	3	of	of	IN
cord-006860-a3b8hyyr	2453	4	heparin	heparin	NN
cord-006860-a3b8hyyr	2453	5	-	-	HYPH
cord-006860-a3b8hyyr	2453	6	dependent	dependent	JJ
cord-006860-a3b8hyyr	2453	7	IgG	igg	NN
cord-006860-a3b8hyyr	2453	8	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2453	9	(	(	-LRB-
cord-006860-a3b8hyyr	2453	10	7.8	7.8	CD
cord-006860-a3b8hyyr	2453	11	%	%	NN
cord-006860-a3b8hyyr	2453	12	)	)	-RRB-
cord-006860-a3b8hyyr	2453	13	was	be	VBD
cord-006860-a3b8hyyr	2453	14	higher	high	JJR
cord-006860-a3b8hyyr	2453	15	in	in	IN
cord-006860-a3b8hyyr	2453	16	the	the	DT
cord-006860-a3b8hyyr	2453	17	UFH	UFH	NNP
cord-006860-a3b8hyyr	2453	18	treated	treat	VBN
cord-006860-a3b8hyyr	2453	19	group	group	NN
cord-006860-a3b8hyyr	2453	20	than	than	IN
cord-006860-a3b8hyyr	2453	21	in	in	IN
cord-006860-a3b8hyyr	2453	22	patients	patient	NNS
cord-006860-a3b8hyyr	2453	23	treated	treat	VBN
cord-006860-a3b8hyyr	2453	24	with	with	IN
cord-006860-a3b8hyyr	2453	25	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2453	26	(	(	-LRB-
cord-006860-a3b8hyyr	2453	27	2.2	2.2	CD
cord-006860-a3b8hyyr	2453	28	%	%	NN
cord-006860-a3b8hyyr	2453	29	)	)	-RRB-
cord-006860-a3b8hyyr	2453	30	.	.	.
cord-006860-a3b8hyyr	2454	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	2454	2	patient	patient	NN
cord-006860-a3b8hyyr	2454	3	was	be	VBD
cord-006860-a3b8hyyr	2454	4	a	a	DT
cord-006860-a3b8hyyr	2454	5	male	male	JJ
cord-006860-a3b8hyyr	2454	6	caucasian	caucasian	JJ
cord-006860-a3b8hyyr	2454	7	white	white	JJ
cord-006860-a3b8hyyr	2454	8	,	,	,
cord-006860-a3b8hyyr	2454	9	62	62	CD
cord-006860-a3b8hyyr	2454	10	years	year	NNS
cord-006860-a3b8hyyr	2454	11	of	of	IN
cord-006860-a3b8hyyr	2454	12	age	age	NN
cord-006860-a3b8hyyr	2454	13	,	,	,
cord-006860-a3b8hyyr	2454	14	otherwise	otherwise	RB
cord-006860-a3b8hyyr	2454	15	in	in	IN
cord-006860-a3b8hyyr	2454	16	good	good	JJ
cord-006860-a3b8hyyr	2454	17	clinical	clinical	JJ
cord-006860-a3b8hyyr	2454	18	condition	condition	NN
cord-006860-a3b8hyyr	2454	19	with	with	IN
cord-006860-a3b8hyyr	2454	20	no	no	DT
cord-006860-a3b8hyyr	2454	21	severe	severe	JJ
cord-006860-a3b8hyyr	2454	22	diseases	disease	NNS
cord-006860-a3b8hyyr	2454	23	in	in	IN
cord-006860-a3b8hyyr	2454	24	his	-PRON-	PRP$
cord-006860-a3b8hyyr	2454	25	PMH	pmh	NN
cord-006860-a3b8hyyr	2454	26	.	.	.
cord-006860-a3b8hyyr	2455	1	Both	both	DT
cord-006860-a3b8hyyr	2455	2	parents	parent	NNS
cord-006860-a3b8hyyr	2455	3	,	,	,
cord-006860-a3b8hyyr	2455	4	however	however	RB
cord-006860-a3b8hyyr	2455	5	,	,	,
cord-006860-a3b8hyyr	2455	6	had	have	VBD
cord-006860-a3b8hyyr	2455	7	suffered	suffer	VBN
cord-006860-a3b8hyyr	2455	8	several	several	JJ
cord-006860-a3b8hyyr	2455	9	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	2455	10	episodes	episode	NNS
cord-006860-a3b8hyyr	2455	11	.	.	.
cord-006860-a3b8hyyr	2456	1	The	the	DT
cord-006860-a3b8hyyr	2456	2	patient	patient	NN
cord-006860-a3b8hyyr	2456	3	was	be	VBD
cord-006860-a3b8hyyr	2456	4	admitted	admit	VBN
cord-006860-a3b8hyyr	2456	5	to	to	IN
cord-006860-a3b8hyyr	2456	6	the	the	DT
cord-006860-a3b8hyyr	2456	7	hospital	hospital	NN
cord-006860-a3b8hyyr	2456	8	in	in	IN
cord-006860-a3b8hyyr	2456	9	September	September	NNP
cord-006860-a3b8hyyr	2456	10	"	"	''
cord-006860-a3b8hyyr	2456	11	95	95	CD
cord-006860-a3b8hyyr	2456	12	with	with	IN
cord-006860-a3b8hyyr	2456	13	clinical	clinical	JJ
cord-006860-a3b8hyyr	2456	14	signs	sign	NNS
cord-006860-a3b8hyyr	2456	15	of	of	IN
cord-006860-a3b8hyyr	2456	16	a	a	DT
cord-006860-a3b8hyyr	2456	17	deep	deep	JJ
cord-006860-a3b8hyyr	2456	18	vein	vein	NN
cord-006860-a3b8hyyr	2456	19	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2456	20	(	(	-LRB-
cord-006860-a3b8hyyr	2456	21	DVT	DVT	NNP
cord-006860-a3b8hyyr	2456	22	)	)	-RRB-
cord-006860-a3b8hyyr	2456	23	of	of	IN
cord-006860-a3b8hyyr	2456	24	the	the	DT
cord-006860-a3b8hyyr	2456	25	right	right	JJ
cord-006860-a3b8hyyr	2456	26	leg	leg	NN
cord-006860-a3b8hyyr	2456	27	.	.	.
cord-006860-a3b8hyyr	2457	1	The	the	DT
cord-006860-a3b8hyyr	2457	2	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	2457	3	was	be	VBD
cord-006860-a3b8hyyr	2457	4	phiebographically	phiebographically	RB
cord-006860-a3b8hyyr	2457	5	confirmed	confirm	VBN
cord-006860-a3b8hyyr	2457	6	.	.	.
cord-006860-a3b8hyyr	2458	1	After	after	IN
cord-006860-a3b8hyyr	2458	2	having	have	VBG
cord-006860-a3b8hyyr	2458	3	given	give	VBN
cord-006860-a3b8hyyr	2458	4	informed	informed	JJ
cord-006860-a3b8hyyr	2458	5	consent	consent	NN
cord-006860-a3b8hyyr	2458	6	the	the	DT
cord-006860-a3b8hyyr	2458	7	patient	patient	NN
cord-006860-a3b8hyyr	2458	8	was	be	VBD
cord-006860-a3b8hyyr	2458	9	treated	treat	VBN
cord-006860-a3b8hyyr	2458	10	with	with	IN
cord-006860-a3b8hyyr	2458	11	5	5	CD
cord-006860-a3b8hyyr	2458	12	cycles	cycle	NNS
cord-006860-a3b8hyyr	2458	13	of	of	IN
cord-006860-a3b8hyyr	2458	14	r	r	NNP
cord-006860-a3b8hyyr	2458	15	-	-	HYPH
cord-006860-a3b8hyyr	2458	16	TPA	tpa	NN
cord-006860-a3b8hyyr	2458	17	(	(	-LRB-
cord-006860-a3b8hyyr	2458	18	loco	loco	NN
cord-006860-a3b8hyyr	2458	19	-	-	HYPH
cord-006860-a3b8hyyr	2458	20	regional	regional	JJ
cord-006860-a3b8hyyr	2458	21	application	application	NN
cord-006860-a3b8hyyr	2458	22	)	)	-RRB-
cord-006860-a3b8hyyr	2458	23	and	and	CC
cord-006860-a3b8hyyr	2458	24	3	3	CD
cord-006860-a3b8hyyr	2458	25	cycles	cycle	NNS
cord-006860-a3b8hyyr	2458	26	of	of	IN
cord-006860-a3b8hyyr	2458	27	UHSK	UHSK	NNP
cord-006860-a3b8hyyr	2458	28	as	as	IN
cord-006860-a3b8hyyr	2458	29	part	part	NN
cord-006860-a3b8hyyr	2458	30	of	of	IN
cord-006860-a3b8hyyr	2458	31	a	a	DT
cord-006860-a3b8hyyr	2458	32	clinical	clinical	JJ
cord-006860-a3b8hyyr	2458	33	trial	trial	NN
cord-006860-a3b8hyyr	2458	34	(	(	-LRB-
cord-006860-a3b8hyyr	2458	35	UHSK	UHSK	NNP
cord-006860-a3b8hyyr	2458	36	vs.	vs.	FW
cord-006860-a3b8hyyr	2458	37	rTPA	rTPA	NNP
cord-006860-a3b8hyyr	2458	38	,	,	,
cord-006860-a3b8hyyr	2458	39	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	2458	40	/	/	SYM
cord-006860-a3b8hyyr	2458	41	M	M	NNP
cord-006860-a3b8hyyr	2458	42	)	)	-RRB-
cord-006860-a3b8hyyr	2458	43	.	.	.
cord-006860-a3b8hyyr	2459	1	Lysis	lysis	NN
cord-006860-a3b8hyyr	2459	2	was	be	VBD
cord-006860-a3b8hyyr	2459	3	successful	successful	JJ
cord-006860-a3b8hyyr	2459	4	with	with	IN
cord-006860-a3b8hyyr	2459	5	complete	complete	JJ
cord-006860-a3b8hyyr	2459	6	recanalisation	recanalisation	NN
cord-006860-a3b8hyyr	2459	7	of	of	IN
cord-006860-a3b8hyyr	2459	8	the	the	DT
cord-006860-a3b8hyyr	2459	9	veins	vein	NNS
cord-006860-a3b8hyyr	2459	10	.	.	.
cord-006860-a3b8hyyr	2460	1	After	after	IN
cord-006860-a3b8hyyr	2460	2	completion	completion	NN
cord-006860-a3b8hyyr	2460	3	of	of	IN
cord-006860-a3b8hyyr	2460	4	lysis	lysis	NN
cord-006860-a3b8hyyr	2460	5	the	the	DT
cord-006860-a3b8hyyr	2460	6	patient	patient	NN
cord-006860-a3b8hyyr	2460	7	was	be	VBD
cord-006860-a3b8hyyr	2460	8	further	further	RB
cord-006860-a3b8hyyr	2460	9	anticoagulated	anticoagulate	VBN
cord-006860-a3b8hyyr	2460	10	with	with	IN
cord-006860-a3b8hyyr	2460	11	coumarin	coumarin	NN
cord-006860-a3b8hyyr	2460	12	overlapped	overlap	VBN
cord-006860-a3b8hyyr	2460	13	by	by	IN
cord-006860-a3b8hyyr	2460	14	heparin	heparin	NN
cord-006860-a3b8hyyr	2460	15	(	(	-LRB-
cord-006860-a3b8hyyr	2460	16	UFH	UFH	NNP
cord-006860-a3b8hyyr	2460	17	)	)	-RRB-
cord-006860-a3b8hyyr	2460	18	.	.	.
cord-006860-a3b8hyyr	2461	1	As	as	IN
cord-006860-a3b8hyyr	2461	2	a	a	DT
cord-006860-a3b8hyyr	2461	3	complication	complication	NN
cord-006860-a3b8hyyr	2461	4	the	the	DT
cord-006860-a3b8hyyr	2461	5	patient	patient	NN
cord-006860-a3b8hyyr	2461	6	suffered	suffer	VBD
cord-006860-a3b8hyyr	2461	7	from	from	IN
cord-006860-a3b8hyyr	2461	8	a	a	DT
cord-006860-a3b8hyyr	2461	9	retroperitoneal	retroperitoneal	JJ
cord-006860-a3b8hyyr	2461	10	and	and	CC
cord-006860-a3b8hyyr	2461	11	an	an	DT
cord-006860-a3b8hyyr	2461	12	upper	upper	JJ
cord-006860-a3b8hyyr	2461	13	GI4ract	GI4ract	NNP
cord-006860-a3b8hyyr	2461	14	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2461	15	from	from	IN
cord-006860-a3b8hyyr	2461	16	esophagitis	esophagitis	JJ
cord-006860-a3b8hyyr	2461	17	grade	grade	NN
cord-006860-a3b8hyyr	2461	18	II	II	NNP
cord-006860-a3b8hyyr	2461	19	to	to	IN
cord-006860-a3b8hyyr	2461	20	HI	HI	NNP
cord-006860-a3b8hyyr	2461	21	while	while	IN
cord-006860-a3b8hyyr	2461	22	being	be	VBG
cord-006860-a3b8hyyr	2461	23	on	on	IN
cord-006860-a3b8hyyr	2461	24	coumarin	coumarin	NN
cord-006860-a3b8hyyr	2461	25	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2461	26	.	.	.
cord-006860-a3b8hyyr	2462	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	2462	2	the	the	DT
cord-006860-a3b8hyyr	2462	3	patient	patient	NN
cord-006860-a3b8hyyr	2462	4	was	be	VBD
cord-006860-a3b8hyyr	2462	5	put	put	VBN
cord-006860-a3b8hyyr	2462	6	on	on	IN
cord-006860-a3b8hyyr	2462	7	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2462	8	and	and	CC
cord-006860-a3b8hyyr	2462	9	then	then	RB
cord-006860-a3b8hyyr	2462	10	discharged	discharge	VBD
cord-006860-a3b8hyyr	2462	11	with	with	IN
cord-006860-a3b8hyyr	2462	12	this	this	DT
cord-006860-a3b8hyyr	2462	13	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2462	14	.	.	.
cord-006860-a3b8hyyr	2463	1	After	after	IN
cord-006860-a3b8hyyr	2463	2	less	less	JJR
cord-006860-a3b8hyyr	2463	3	than	than	IN
cord-006860-a3b8hyyr	2463	4	two	two	CD
cord-006860-a3b8hyyr	2463	5	weeks	week	NNS
cord-006860-a3b8hyyr	2463	6	the	the	DT
cord-006860-a3b8hyyr	2463	7	patient	patient	NN
cord-006860-a3b8hyyr	2463	8	presented	present	VBD
cord-006860-a3b8hyyr	2463	9	again	again	RB
cord-006860-a3b8hyyr	2463	10	to	to	IN
cord-006860-a3b8hyyr	2463	11	the	the	DT
cord-006860-a3b8hyyr	2463	12	hospital	hospital	NN
cord-006860-a3b8hyyr	2463	13	with	with	IN
cord-006860-a3b8hyyr	2463	14	a	a	DT
cord-006860-a3b8hyyr	2463	15	relapse	relapse	NN
cord-006860-a3b8hyyr	2463	16	of	of	IN
cord-006860-a3b8hyyr	2463	17	DVT	DVT	NNP
cord-006860-a3b8hyyr	2463	18	in	in	IN
cord-006860-a3b8hyyr	2463	19	the	the	DT
cord-006860-a3b8hyyr	2463	20	same	same	JJ
cord-006860-a3b8hyyr	2463	21	leg	leg	NN
cord-006860-a3b8hyyr	2463	22	.	.	.
cord-006860-a3b8hyyr	2464	1	Phiebographically	phiebographically	RB
cord-006860-a3b8hyyr	2464	2	nearly	nearly	RB
cord-006860-a3b8hyyr	2464	3	all	all	DT
cord-006860-a3b8hyyr	2464	4	deep	deep	JJ
cord-006860-a3b8hyyr	2464	5	veins	vein	NNS
cord-006860-a3b8hyyr	2464	6	were	be	VBD
cord-006860-a3b8hyyr	2464	7	occluded	occlude	VBN
cord-006860-a3b8hyyr	2464	8	to	to	IN
cord-006860-a3b8hyyr	2464	9	a	a	DT
cord-006860-a3b8hyyr	2464	10	higher	high	JJR
cord-006860-a3b8hyyr	2464	11	degree	degree	NN
cord-006860-a3b8hyyr	2464	12	than	than	IN
cord-006860-a3b8hyyr	2464	13	before	before	RB
cord-006860-a3b8hyyr	2464	14	,	,	,
cord-006860-a3b8hyyr	2464	15	i.	i.	NNP
cord-006860-a3b8hyyr	2464	16	e.	e.	NNP
cord-006860-a3b8hyyr	2464	17	also	also	RB
cord-006860-a3b8hyyr	2464	18	with	with	IN
cord-006860-a3b8hyyr	2464	19	concomitant	concomitant	JJ
cord-006860-a3b8hyyr	2464	20	pelvic	pelvic	JJ
cord-006860-a3b8hyyr	2464	21	vein	vein	NN
cord-006860-a3b8hyyr	2464	22	affection	affection	NN
cord-006860-a3b8hyyr	2464	23	and	and	CC
cord-006860-a3b8hyyr	2464	24	with	with	IN
cord-006860-a3b8hyyr	2464	25	hea~	hea~	NNP
cord-006860-a3b8hyyr	2464	26	3	3	CD
cord-006860-a3b8hyyr	2464	27	,	,	,
cord-006860-a3b8hyyr	2464	28	swelling	swell	VBG
cord-006860-a3b8hyyr	2464	29	of	of	IN
cord-006860-a3b8hyyr	2464	30	the	the	DT
cord-006860-a3b8hyyr	2464	31	whole	whole	JJ
cord-006860-a3b8hyyr	2464	32	leg	leg	NN
cord-006860-a3b8hyyr	2464	33	.	.	.
cord-006860-a3b8hyyr	2465	1	Blood	blood	NN
cord-006860-a3b8hyyr	2465	2	count	count	NN
cord-006860-a3b8hyyr	2465	3	showed	show	VBD
cord-006860-a3b8hyyr	2465	4	a	a	DT
cord-006860-a3b8hyyr	2465	5	marked	marked	JJ
cord-006860-a3b8hyyr	2465	6	decrease	decrease	NN
cord-006860-a3b8hyyr	2465	7	of	of	IN
cord-006860-a3b8hyyr	2465	8	platelets	platelet	NNS
cord-006860-a3b8hyyr	2465	9	to	to	IN
cord-006860-a3b8hyyr	2465	10	27	27	CD
cord-006860-a3b8hyyr	2465	11	/	/	SYM
cord-006860-a3b8hyyr	2465	12	nl	nl	NN
cord-006860-a3b8hyyr	2465	13	.	.	.
cord-006860-a3b8hyyr	2466	1	The	the	DT
cord-006860-a3b8hyyr	2466	2	platelet	platelet	NN
cord-006860-a3b8hyyr	2466	3	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2466	4	test	test	NN
cord-006860-a3b8hyyr	2466	5	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	2466	6	a	a	DT
cord-006860-a3b8hyyr	2466	7	HAT	hat	NN
cord-006860-a3b8hyyr	2466	8	-	-	HYPH
cord-006860-a3b8hyyr	2466	9	syndrome	syndrome	NN
cord-006860-a3b8hyyr	2466	10	which	which	WDT
cord-006860-a3b8hyyr	2466	11	was	be	VBD
cord-006860-a3b8hyyr	2466	12	confirmed	confirm	VBN
cord-006860-a3b8hyyr	2466	13	by	by	IN
cord-006860-a3b8hyyr	2466	14	the	the	DT
cord-006860-a3b8hyyr	2466	15	HIPA	HIPA	NNP
cord-006860-a3b8hyyr	2466	16	-	-	HYPH
cord-006860-a3b8hyyr	2466	17	assay	assay	NN
cord-006860-a3b8hyyr	2466	18	.	.	.
cord-006860-a3b8hyyr	2467	1	The	the	DT
cord-006860-a3b8hyyr	2467	2	heparinoid	heparinoid	JJ
cord-006860-a3b8hyyr	2467	3	Orgaran	Orgaran	NNP
cord-006860-a3b8hyyr	2468	1	®	®	NNP
cord-006860-a3b8hyyr	2468	2	was	be	VBD
cord-006860-a3b8hyyr	2468	3	not	not	RB
cord-006860-a3b8hyyr	2468	4	reactive	reactive	JJ
cord-006860-a3b8hyyr	2468	5	in	in	IN
cord-006860-a3b8hyyr	2468	6	the	the	DT
cord-006860-a3b8hyyr	2468	7	assay	assay	NN
cord-006860-a3b8hyyr	2468	8	.	.	.
cord-006860-a3b8hyyr	2469	1	Having	have	VBG
cord-006860-a3b8hyyr	2469	2	seen	see	VBN
cord-006860-a3b8hyyr	2469	3	a	a	DT
cord-006860-a3b8hyyr	2469	4	previous	previous	JJ
cord-006860-a3b8hyyr	2469	5	bleeding	bleeding	NN
cord-006860-a3b8hyyr	2469	6	episode	episode	NN
cord-006860-a3b8hyyr	2469	7	in	in	IN
cord-006860-a3b8hyyr	2469	8	this	this	DT
cord-006860-a3b8hyyr	2469	9	patient	patient	NN
cord-006860-a3b8hyyr	2469	10	,	,	,
cord-006860-a3b8hyyr	2469	11	we	-PRON-	PRP
cord-006860-a3b8hyyr	2469	12	did	do	VBD
cord-006860-a3b8hyyr	2469	13	not	not	RB
cord-006860-a3b8hyyr	2469	14	see	see	VB
cord-006860-a3b8hyyr	2469	15	an	an	DT
cord-006860-a3b8hyyr	2469	16	indication	indication	NN
cord-006860-a3b8hyyr	2469	17	for	for	IN
cord-006860-a3b8hyyr	2469	18	another	another	DT
cord-006860-a3b8hyyr	2469	19	b'sis	b'sis	CD
cord-006860-a3b8hyyr	2469	20	therapy	therapy	NN
cord-006860-a3b8hyyr	2469	21	.	.	.
cord-006860-a3b8hyyr	2470	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	2470	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	2470	3	decided	decide	VBD
cord-006860-a3b8hyyr	2470	4	to	to	TO
cord-006860-a3b8hyyr	2470	5	put	put	VB
cord-006860-a3b8hyyr	2470	6	the	the	DT
cord-006860-a3b8hyyr	2470	7	patient	patient	NN
cord-006860-a3b8hyyr	2470	8	on	on	IN
cord-006860-a3b8hyyr	2470	9	an	an	DT
cord-006860-a3b8hyyr	2470	10	intermediate	intermediate	JJ
cord-006860-a3b8hyyr	2470	11	dose	dose	NN
cord-006860-a3b8hyyr	2470	12	of	of	IN
cord-006860-a3b8hyyr	2470	13	coumarin	coumarin	NN
cord-006860-a3b8hyyr	2470	14	overlapped	overlap	VBN
cord-006860-a3b8hyyr	2470	15	by	by	IN
cord-006860-a3b8hyyr	2470	16	hiradin	hiradin	NNP
cord-006860-a3b8hyyr	2470	17	(	(	-LRB-
cord-006860-a3b8hyyr	2470	18	HAT	hat	NN
cord-006860-a3b8hyyr	2470	19	study	study	NN
cord-006860-a3b8hyyr	2470	20	,	,	,
cord-006860-a3b8hyyr	2470	21	Behring	Behring	NNP
cord-006860-a3b8hyyr	2470	22	)	)	-RRB-
cord-006860-a3b8hyyr	2470	23	instead	instead	RB
cord-006860-a3b8hyyr	2470	24	of	of	IN
cord-006860-a3b8hyyr	2471	1	Orgaran	Orgaran	NNP
cord-006860-a3b8hyyr	2471	2	®	®	NNP
cord-006860-a3b8hyyr	2471	3	,	,	,
cord-006860-a3b8hyyr	2471	4	since	since	IN
cord-006860-a3b8hyyr	2471	5	hirudin	hirudin	NN
cord-006860-a3b8hyyr	2471	6	allows	allow	VBZ
cord-006860-a3b8hyyr	2471	7	a	a	DT
cord-006860-a3b8hyyr	2471	8	much	much	RB
cord-006860-a3b8hyyr	2471	9	more	more	RBR
cord-006860-a3b8hyyr	2471	10	precise	precise	JJ
cord-006860-a3b8hyyr	2471	11	dose	dose	NN
cord-006860-a3b8hyyr	2471	12	adjustment	adjustment	NN
cord-006860-a3b8hyyr	2471	13	.	.	.
cord-006860-a3b8hyyr	2472	1	After	after	IN
cord-006860-a3b8hyyr	2472	2	10	10	CD
cord-006860-a3b8hyyr	2472	3	days	day	NNS
cord-006860-a3b8hyyr	2472	4	the	the	DT
cord-006860-a3b8hyyr	2472	5	patient	patient	NN
cord-006860-a3b8hyyr	2472	6	was	be	VBD
cord-006860-a3b8hyyr	2472	7	discharged	discharge	VBN
cord-006860-a3b8hyyr	2472	8	with	with	IN
cord-006860-a3b8hyyr	2472	9	no	no	DT
cord-006860-a3b8hyyr	2472	10	further	further	JJ
cord-006860-a3b8hyyr	2472	11	complications	complication	NNS
cord-006860-a3b8hyyr	2472	12	.	.	.
cord-006860-a3b8hyyr	2473	1	Risk	risk	NN
cord-006860-a3b8hyyr	2473	2	factors	factor	NNS
cord-006860-a3b8hyyr	2473	3	for	for	IN
cord-006860-a3b8hyyr	2473	4	DVT	DVT	NNP
cord-006860-a3b8hyyr	2473	5	have	have	VBP
cord-006860-a3b8hyyr	2473	6	not	not	RB
cord-006860-a3b8hyyr	2473	7	been	be	VBN
cord-006860-a3b8hyyr	2473	8	detected	detect	VBN
cord-006860-a3b8hyyr	2473	9	until	until	IN
cord-006860-a3b8hyyr	2473	10	now	now	RB
cord-006860-a3b8hyyr	2473	11	.	.	.
cord-006860-a3b8hyyr	2474	1	To	to	IN
cord-006860-a3b8hyyr	2474	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2474	3	knowledge	knowledge	NN
cord-006860-a3b8hyyr	2474	4	this	this	DT
cord-006860-a3b8hyyr	2474	5	patient	patient	NN
cord-006860-a3b8hyyr	2474	6	is	be	VBZ
cord-006860-a3b8hyyr	2474	7	one	one	CD
cord-006860-a3b8hyyr	2474	8	of	of	IN
cord-006860-a3b8hyyr	2474	9	the	the	DT
cord-006860-a3b8hyyr	2474	10	first	first	JJ
cord-006860-a3b8hyyr	2474	11	cases	case	NNS
cord-006860-a3b8hyyr	2474	12	of	of	IN
cord-006860-a3b8hyyr	2474	13	HAT	hat	NN
cord-006860-a3b8hyyr	2474	14	-	-	HYPH
cord-006860-a3b8hyyr	2474	15	syndrome	syndrome	NN
cord-006860-a3b8hyyr	2474	16	induced	induce	VBN
cord-006860-a3b8hyyr	2474	17	by	by	IN
cord-006860-a3b8hyyr	2474	18	LMVeH.	LMVeH.	NNS
cord-006860-a3b8hyyr	2474	19	Under	under	IN
cord-006860-a3b8hyyr	2474	20	routine	routine	JJ
cord-006860-a3b8hyyr	2474	21	conditions	condition	NNS
cord-006860-a3b8hyyr	2475	1	aPTT	aptt	CD
cord-006860-a3b8hyyr	2476	1	is	be	VBZ
cord-006860-a3b8hyyr	2476	2	the	the	DT
cord-006860-a3b8hyyr	2476	3	most	most	RBS
cord-006860-a3b8hyyr	2476	4	frequently	frequently	RB
cord-006860-a3b8hyyr	2476	5	used	use	VBN
cord-006860-a3b8hyyr	2476	6	test	test	NN
cord-006860-a3b8hyyr	2476	7	method	method	NN
cord-006860-a3b8hyyr	2476	8	for	for	IN
cord-006860-a3b8hyyr	2476	9	the	the	DT
cord-006860-a3b8hyyr	2476	10	surveillance	surveillance	NN
cord-006860-a3b8hyyr	2476	11	of	of	IN
cord-006860-a3b8hyyr	2476	12	patients	patient	NNS
cord-006860-a3b8hyyr	2476	13	undergoing	undergo	VBG
cord-006860-a3b8hyyr	2476	14	hepann	hepann	NNP
cord-006860-a3b8hyyr	2476	15	therapy	therapy	NN
cord-006860-a3b8hyyr	2476	16	.	.	.
cord-006860-a3b8hyyr	2477	1	In	in	IN
cord-006860-a3b8hyyr	2477	2	literature	literature	NN
cord-006860-a3b8hyyr	2477	3	a	a	DT
cord-006860-a3b8hyyr	2477	4	1,5	1,5	CD
cord-006860-a3b8hyyr	2477	5	fold	fold	NN
cord-006860-a3b8hyyr	2477	6	to	to	IN
cord-006860-a3b8hyyr	2477	7	2,5	2,5	CD
cord-006860-a3b8hyyr	2477	8	fold	fold	VB
cord-006860-a3b8hyyr	2477	9	prolongation	prolongation	NN
cord-006860-a3b8hyyr	2477	10	of	of	IN
cord-006860-a3b8hyyr	2477	11	the	the	DT
cord-006860-a3b8hyyr	2477	12	initial	initial	JJ
cord-006860-a3b8hyyr	2477	13	value	value	NN
cord-006860-a3b8hyyr	2477	14	is	be	VBZ
cord-006860-a3b8hyyr	2477	15	recommended	recommend	VBN
cord-006860-a3b8hyyr	2477	16	for	for	IN
cord-006860-a3b8hyyr	2477	17	individual	individual	JJ
cord-006860-a3b8hyyr	2477	18	therapy	therapy	NN
cord-006860-a3b8hyyr	2477	19	a	a	DT
cord-006860-a3b8hyyr	2477	20	~	~	NFP
cord-006860-a3b8hyyr	2477	21	IXatian	IXatian	NNP
cord-006860-a3b8hyyr	2477	22	.	.	.
cord-006860-a3b8hyyr	2478	1	In	in	IN
cord-006860-a3b8hyyr	2478	2	contrast	contrast	NN
cord-006860-a3b8hyyr	2478	3	to	to	IN
cord-006860-a3b8hyyr	2478	4	the	the	DT
cord-006860-a3b8hyyr	2478	5	control	control	NN
cord-006860-a3b8hyyr	2478	6	of	of	IN
cord-006860-a3b8hyyr	2478	7	the	the	DT
cord-006860-a3b8hyyr	2478	8	enmarin	enmarin	NNP
cord-006860-a3b8hyyr	2478	9	therapy	therapy	NN
cord-006860-a3b8hyyr	2478	10	by	by	IN
cord-006860-a3b8hyyr	2478	11	means	mean	NNS
cord-006860-a3b8hyyr	2478	12	of	of	IN
cord-006860-a3b8hyyr	2478	13	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	2478	14	time	time	NN
cord-006860-a3b8hyyr	2478	15	measurement	measurement	NN
cord-006860-a3b8hyyr	2478	16	the	the	DT
cord-006860-a3b8hyyr	2478	17	individual	individual	JJ
cord-006860-a3b8hyyr	2478	18	hupafin	hupafin	NN
cord-006860-a3b8hyyr	2478	19	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	2478	20	of	of	IN
cord-006860-a3b8hyyr	2478	21	the	the	DT
cord-006860-a3b8hyyr	2478	22	~	~	CD
cord-006860-a3b8hyyr	2478	23	reagents	reagent	NNS
cord-006860-a3b8hyyr	2478	24	of	of	IN
cord-006860-a3b8hyyr	2478	25	this	this	DT
cord-006860-a3b8hyyr	2478	26	standard	standard	JJ
cord-006860-a3b8hyyr	2478	27	value	value	NN
cord-006860-a3b8hyyr	2478	28	hardly	hardly	RB
cord-006860-a3b8hyyr	2478	29	receives	receive	VBZ
cord-006860-a3b8hyyr	2478	30	notice	notice	NN
cord-006860-a3b8hyyr	2478	31	.	.	.
cord-006860-a3b8hyyr	2479	1	Commercially	commercially	RB
cord-006860-a3b8hyyr	2479	2	marketed	market	VBN
cord-006860-a3b8hyyr	2479	3	~	~	CD
cord-006860-a3b8hyyr	2479	4	reagents	reagent	NNS
cord-006860-a3b8hyyr	2479	5	differ	differ	VBP
cord-006860-a3b8hyyr	2479	6	from	from	IN
cord-006860-a3b8hyyr	2479	7	one	one	CD
cord-006860-a3b8hyyr	2479	8	another	another	DT
cord-006860-a3b8hyyr	2479	9	method	method	NN
cord-006860-a3b8hyyr	2479	10	and	and	CC
cord-006860-a3b8hyyr	2479	11	concentration	concentration	NN
cord-006860-a3b8hyyr	2479	12	of	of	IN
cord-006860-a3b8hyyr	2479	13	the	the	DT
cord-006860-a3b8hyyr	2479	14	activator	activator	NN
cord-006860-a3b8hyyr	2479	15	as	as	RB
cord-006860-a3b8hyyr	2479	16	well	well	RB
cord-006860-a3b8hyyr	2479	17	as	as	IN
cord-006860-a3b8hyyr	2479	18	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2479	19	phosphelipids	phosphelipid	NNS
cord-006860-a3b8hyyr	2479	20	.	.	.
cord-006860-a3b8hyyr	2480	1	When	when	WRB
cord-006860-a3b8hyyr	2480	2	choosing	choose	VBG
cord-006860-a3b8hyyr	2480	3	a	a	DT
cord-006860-a3b8hyyr	2480	4	reagent	reagent	NN
cord-006860-a3b8hyyr	2480	5	the	the	DT
cord-006860-a3b8hyyr	2480	6	user	user	NN
cord-006860-a3b8hyyr	2480	7	must	must	MD
cord-006860-a3b8hyyr	2480	8	only	only	RB
cord-006860-a3b8hyyr	2480	9	take	take	VB
cord-006860-a3b8hyyr	2480	10	into	into	IN
cord-006860-a3b8hyyr	2480	11	consideration	consideration	NN
cord-006860-a3b8hyyr	2480	12	the	the	DT
cord-006860-a3b8hyyr	2480	13	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	2480	14	against	against	IN
cord-006860-a3b8hyyr	2480	15	its	-PRON-	PRP$
cord-006860-a3b8hyyr	2480	16	factors	factor	NNS
cord-006860-a3b8hyyr	2480	17	,	,	,
cord-006860-a3b8hyyr	2480	18	heparin	heparin	NN
cord-006860-a3b8hyyr	2480	19	and	and	CC
cord-006860-a3b8hyyr	2480	20	lupus	lupus	NN
cord-006860-a3b8hyyr	2480	21	but	but	CC
cord-006860-a3b8hyyr	2480	22	also	also	RB
cord-006860-a3b8hyyr	2480	23	the	the	DT
cord-006860-a3b8hyyr	2480	24	adalXability	adalxability	NN
cord-006860-a3b8hyyr	2480	25	of	of	IN
cord-006860-a3b8hyyr	2480	26	the	the	DT
cord-006860-a3b8hyyr	2480	27	reagent	reagent	NN
cord-006860-a3b8hyyr	2480	28	towards	towards	IN
cord-006860-a3b8hyyr	2480	29	the	the	DT
cord-006860-a3b8hyyr	2480	30	given	give	VBN
cord-006860-a3b8hyyr	2480	31	measurement	measurement	NN
cord-006860-a3b8hyyr	2480	32	system	system	NN
cord-006860-a3b8hyyr	2480	33	(	(	-LRB-
cord-006860-a3b8hyyr	2480	34	software	software	NN
cord-006860-a3b8hyyr	2480	35	variability	variability	NN
cord-006860-a3b8hyyr	2480	36	towards	towards	IN
cord-006860-a3b8hyyr	2480	37	incubation	incubation	NN
cord-006860-a3b8hyyr	2480	38	time	time	NN
cord-006860-a3b8hyyr	2480	39	,	,	,
cord-006860-a3b8hyyr	2480	40	sodimentalion	sodimentalion	NN
cord-006860-a3b8hyyr	2480	41	problems	problem	NNS
cord-006860-a3b8hyyr	2480	42	in	in	IN
cord-006860-a3b8hyyr	2480	43	reagents	reagent	NNS
cord-006860-a3b8hyyr	2480	44	with	with	IN
cord-006860-a3b8hyyr	2480	45	high	high	JJ
cord-006860-a3b8hyyr	2480	46	kaolin	kaolin	NN
cord-006860-a3b8hyyr	2480	47	concentration	concentration	NN
cord-006860-a3b8hyyr	2480	48	)	)	-RRB-
cord-006860-a3b8hyyr	2480	49	.	.	.
cord-006860-a3b8hyyr	2481	1	Reagents	reagent	NNS
cord-006860-a3b8hyyr	2481	2	offering	offer	VBG
cord-006860-a3b8hyyr	2481	3	a	a	DT
cord-006860-a3b8hyyr	2481	4	high	high	JJ
cord-006860-a3b8hyyr	2481	5	heparin	heparin	NN
cord-006860-a3b8hyyr	2481	6	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	2481	7	already	already	RB
cord-006860-a3b8hyyr	2481	8	are	be	VBP
cord-006860-a3b8hyyr	2481	9	showing	show	VBG
cord-006860-a3b8hyyr	2481	10	a	a	DT
cord-006860-a3b8hyyr	2481	11	prolongation	prolongation	NN
cord-006860-a3b8hyyr	2481	12	of	of	IN
cord-006860-a3b8hyyr	2481	13	the	the	DT
cord-006860-a3b8hyyr	2481	14	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2481	15	time	time	NN
cord-006860-a3b8hyyr	2481	16	at	at	IN
cord-006860-a3b8hyyr	2481	17	low	low	JJ
cord-006860-a3b8hyyr	2481	18	heparin	heparin	NN
cord-006860-a3b8hyyr	2481	19	dosage	dosage	NN
cord-006860-a3b8hyyr	2481	20	(	(	-LRB-
cord-006860-a3b8hyyr	2481	21	0.1	0.1	CD
cord-006860-a3b8hyyr	2481	22	-0.3	-0.3	CD
cord-006860-a3b8hyyr	2481	23	U	U	NNP
cord-006860-a3b8hyyr	2481	24	/	/	SYM
cord-006860-a3b8hyyr	2481	25	ml	ml	NN
cord-006860-a3b8hyyr	2481	26	)	)	-RRB-
cord-006860-a3b8hyyr	2481	27	.	.	.
cord-006860-a3b8hyyr	2482	1	In	in	IN
cord-006860-a3b8hyyr	2482	2	the	the	DT
cord-006860-a3b8hyyr	2482	3	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	2482	4	range	range	NN
cord-006860-a3b8hyyr	2482	5	(	(	-LRB-
cord-006860-a3b8hyyr	2482	6	0.4	0.4	CD
cord-006860-a3b8hyyr	2482	7	-0.8	-0.8	NN
cord-006860-a3b8hyyr	2482	8	U	U	NNP
cord-006860-a3b8hyyr	2482	9	/	/	SYM
cord-006860-a3b8hyyr	2482	10	ml	ml	NN
cord-006860-a3b8hyyr	2482	11	)	)	-RRB-
cord-006860-a3b8hyyr	2482	12	very	very	RB
cord-006860-a3b8hyyr	2482	13	often	often	RB
cord-006860-a3b8hyyr	2482	14	no	no	DT
cord-006860-a3b8hyyr	2482	15	linear	linear	JJ
cord-006860-a3b8hyyr	2482	16	relationship	relationship	NN
cord-006860-a3b8hyyr	2482	17	between	between	IN
cord-006860-a3b8hyyr	2482	18	prolongation	prolongation	NN
cord-006860-a3b8hyyr	2482	19	of	of	IN
cord-006860-a3b8hyyr	2482	20	the	the	DT
cord-006860-a3b8hyyr	2482	21	aPTr	aPTr	NNS
cord-006860-a3b8hyyr	2482	22	and	and	CC
cord-006860-a3b8hyyr	2482	23	heparin	heparin	NN
cord-006860-a3b8hyyr	2482	24	concentration	concentration	NN
cord-006860-a3b8hyyr	2482	25	level	level	NN
cord-006860-a3b8hyyr	2482	26	is	be	VBZ
cord-006860-a3b8hyyr	2482	27	found	find	VBN
cord-006860-a3b8hyyr	2482	28	_	_	NN
cord-006860-a3b8hyyr	2483	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	2483	2	very	very	RB
cord-006860-a3b8hyyr	2483	3	often	often	RB
cord-006860-a3b8hyyr	2483	4	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2483	5	times	time	NNS
cord-006860-a3b8hyyr	2483	6	above	above	IN
cord-006860-a3b8hyyr	2483	7	the	the	DT
cord-006860-a3b8hyyr	2483	8	routine	routine	JJ
cord-006860-a3b8hyyr	2483	9	measuring	measuring	NN
cord-006860-a3b8hyyr	2483	10	range	range	NN
cord-006860-a3b8hyyr	2483	11	(	(	-LRB-
cord-006860-a3b8hyyr	2483	12	180	180	CD
cord-006860-a3b8hyyr	2483	13	s	s	NNPS
cord-006860-a3b8hyyr	2483	14	)	)	-RRB-
cord-006860-a3b8hyyr	2483	15	can	can	MD
cord-006860-a3b8hyyr	2483	16	be	be	VB
cord-006860-a3b8hyyr	2483	17	observed	observe	VBN
cord-006860-a3b8hyyr	2483	18	in	in	IN
cord-006860-a3b8hyyr	2483	19	this	this	DT
cord-006860-a3b8hyyr	2483	20	range	range	NN
cord-006860-a3b8hyyr	2483	21	.	.	.
cord-006860-a3b8hyyr	2484	1	Moreover	moreover	RB
cord-006860-a3b8hyyr	2484	2	,	,	,
cord-006860-a3b8hyyr	2484	3	various	various	JJ
cord-006860-a3b8hyyr	2484	4	medical	medical	JJ
cord-006860-a3b8hyyr	2484	5	measuring	measuring	NN
cord-006860-a3b8hyyr	2484	6	devices	device	NNS
cord-006860-a3b8hyyr	2484	7	differ	differ	VBP
cord-006860-a3b8hyyr	2484	8	in	in	IN
cord-006860-a3b8hyyr	2484	9	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2484	10	ability	ability	NN
cord-006860-a3b8hyyr	2484	11	to	to	TO
cord-006860-a3b8hyyr	2484	12	recogniso	recogniso	VB
cord-006860-a3b8hyyr	2484	13	the	the	DT
cord-006860-a3b8hyyr	2484	14	retarded	retarded	JJ
cord-006860-a3b8hyyr	2484	15	entry	entry	NN
cord-006860-a3b8hyyr	2484	16	of	of	IN
cord-006860-a3b8hyyr	2484	17	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2484	18	.	.	.
cord-006860-a3b8hyyr	2485	1	Coagulation	coagulation	NN
cord-006860-a3b8hyyr	2485	2	limes	lime	NNS
cord-006860-a3b8hyyr	2485	3	with	with	IN
cord-006860-a3b8hyyr	2485	4	different	different	JJ
cord-006860-a3b8hyyr	2485	5	aPq'T	aPq'T	NNP
cord-006860-a3b8hyyr	2485	6	reagents	reagent	NNS
cord-006860-a3b8hyyr	2485	7	in	in	IN
cord-006860-a3b8hyyr	2485	8	correlation	correlation	NN
cord-006860-a3b8hyyr	2485	9	with	with	IN
cord-006860-a3b8hyyr	2485	10	the	the	DT
cord-006860-a3b8hyyr	2485	11	heparin	heparin	NN
cord-006860-a3b8hyyr	2485	12	concentration	concentration	NN
cord-006860-a3b8hyyr	2485	13	level	level	NN
cord-006860-a3b8hyyr	2485	14	can	can	MD
cord-006860-a3b8hyyr	2485	15	be	be	VB
cord-006860-a3b8hyyr	2485	16	found	find	VBN
cord-006860-a3b8hyyr	2485	17	in	in	IN
cord-006860-a3b8hyyr	2485	18	the	the	DT
cord-006860-a3b8hyyr	2485	19	adjoined	adjoin	VBN
cord-006860-a3b8hyyr	2485	20	table	table	NN
cord-006860-a3b8hyyr	2485	21	.	.	.
cord-006860-a3b8hyyr	2485	22	 	 	_SP
cord-006860-a3b8hyyr	2486	1	Significantiy	Significantiy	NNS
cord-006860-a3b8hyyr	2486	2	prolonged	prolong	VBD
cord-006860-a3b8hyyr	2486	3	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2486	4	ti.~es	ti.~es	NN
cord-006860-a3b8hyyr	2486	5	of	of	IN
cord-006860-a3b8hyyr	2486	6	aPTT	aptt	CD
cord-006860-a3b8hyyr	2486	7	lead	lead	NN
cord-006860-a3b8hyyr	2486	8	to	to	IN
cord-006860-a3b8hyyr	2486	9	a	a	DT
cord-006860-a3b8hyyr	2486	10	reduction	reduction	NN
cord-006860-a3b8hyyr	2486	11	of	of	IN
cord-006860-a3b8hyyr	2486	12	the	the	DT
cord-006860-a3b8hyyr	2486	13	hel~	hel~	CD
cord-006860-a3b8hyyr	2486	14	dose	dose	NN
cord-006860-a3b8hyyr	2486	15	in	in	IN
cord-006860-a3b8hyyr	2486	16	clinical	clinical	JJ
cord-006860-a3b8hyyr	2486	17	practice	practice	NN
cord-006860-a3b8hyyr	2486	18	.	.	.
cord-006860-a3b8hyyr	2487	1	Due	due	IN
cord-006860-a3b8hyyr	2487	2	to	to	IN
cord-006860-a3b8hyyr	2487	3	the	the	DT
cord-006860-a3b8hyyr	2487	4	discrepancy	discrepancy	NN
cord-006860-a3b8hyyr	2487	5	between	between	IN
cord-006860-a3b8hyyr	2487	6	heparin	heparin	NN
cord-006860-a3b8hyyr	2487	7	concentmon	concentmon	NN
cord-006860-a3b8hyyr	2487	8	level	level	NN
cord-006860-a3b8hyyr	2487	9	and	and	CC
cord-006860-a3b8hyyr	2487	10	the	the	DT
cord-006860-a3b8hyyr	2487	11	prolongation	prolongation	NN
cord-006860-a3b8hyyr	2487	12	of	of	IN
cord-006860-a3b8hyyr	2487	13	the	the	DT
cord-006860-a3b8hyyr	2487	14	aFrT	aFrT	NNP
cord-006860-a3b8hyyr	2487	15	in	in	IN
cord-006860-a3b8hyyr	2487	16	reagents	reagent	NNS
cord-006860-a3b8hyyr	2487	17	with	with	IN
cord-006860-a3b8hyyr	2487	18	a	a	DT
cord-006860-a3b8hyyr	2487	19	non	non	JJ
cord-006860-a3b8hyyr	2487	20	-	-	JJ
cord-006860-a3b8hyyr	2487	21	linear	linear	JJ
cord-006860-a3b8hyyr	2487	22	heparin	heparin	NN
cord-006860-a3b8hyyr	2487	23	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	2487	24	a	a	DT
cord-006860-a3b8hyyr	2487	25	reduction	reduction	NN
cord-006860-a3b8hyyr	2487	26	of	of	IN
cord-006860-a3b8hyyr	2487	27	heparin	heparin	NN
cord-006860-a3b8hyyr	2487	28	dosage	dosage	NN
cord-006860-a3b8hyyr	2487	29	leads	lead	VBZ
cord-006860-a3b8hyyr	2487	30	to	to	IN
cord-006860-a3b8hyyr	2487	31	an	an	DT
cord-006860-a3b8hyyr	2487	32	inmt	inmt	NN
cord-006860-a3b8hyyr	2487	33	~	~	NFP
cord-006860-a3b8hyyr	2487	34	cient	cient	NNP
cord-006860-a3b8hyyr	2487	35	anticeagulalion	anticeagulalion	NNP
cord-006860-a3b8hyyr	2487	36	and	and	CC
cord-006860-a3b8hyyr	2487	37	the	the	DT
cord-006860-a3b8hyyr	2487	38	risk	risk	NN
cord-006860-a3b8hyyr	2487	39	of	of	IN
cord-006860-a3b8hyyr	2487	40	further	further	JJ
cord-006860-a3b8hyyr	2487	41	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2487	42	.	.	.
cord-006860-a3b8hyyr	2488	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	2488	2	the	the	DT
cord-006860-a3b8hyyr	2488	3	producers	producer	NNS
cord-006860-a3b8hyyr	2488	4	should	should	MD
cord-006860-a3b8hyyr	2488	5	be	be	VB
cord-006860-a3b8hyyr	2488	6	asked	ask	VBN
cord-006860-a3b8hyyr	2488	7	to	to	TO
cord-006860-a3b8hyyr	2488	8	include	include	VB
cord-006860-a3b8hyyr	2488	9	precise	precise	JJ
cord-006860-a3b8hyyr	2488	10	directions	direction	NNS
cord-006860-a3b8hyyr	2488	11	on	on	IN
cord-006860-a3b8hyyr	2488	12	the	the	DT
cord-006860-a3b8hyyr	2488	13	heparin	heparin	JJ
cord-006860-a3b8hyyr	2488	14	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	2488	15	of	of	IN
cord-006860-a3b8hyyr	2488	16	the	the	DT
cord-006860-a3b8hyyr	2488	17	aPTT	aptt	CD
cord-006860-a3b8hyyr	2488	18	reagent	reagent	NN
cord-006860-a3b8hyyr	2488	19	in	in	IN
cord-006860-a3b8hyyr	2488	20	the	the	DT
cord-006860-a3b8hyyr	2488	21	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	2488	22	range	range	NN
cord-006860-a3b8hyyr	2488	23	in	in	IN
cord-006860-a3b8hyyr	2488	24	order	order	NN
cord-006860-a3b8hyyr	2488	25	to	to	TO
cord-006860-a3b8hyyr	2488	26	enable	enable	VB
cord-006860-a3b8hyyr	2488	27	an	an	DT
cord-006860-a3b8hyyr	2488	28	optimal	optimal	JJ
cord-006860-a3b8hyyr	2488	29	surveillance	surveillance	NN
cord-006860-a3b8hyyr	2488	30	of	of	IN
cord-006860-a3b8hyyr	2488	31	the	the	DT
cord-006860-a3b8hyyr	2488	32	heparin	heparin	NN
cord-006860-a3b8hyyr	2488	33	therapy	therapy	NN
cord-006860-a3b8hyyr	2488	34	.	.	.
cord-006860-a3b8hyyr	2489	1	A	a	DT
cord-006860-a3b8hyyr	2489	2	coordination	coordination	NN
cord-006860-a3b8hyyr	2489	3	between	between	IN
cord-006860-a3b8hyyr	2489	4	clinic	clinic	NN
cord-006860-a3b8hyyr	2489	5	and	and	CC
cord-006860-a3b8hyyr	2489	6	laboratory	laboratory	NN
cord-006860-a3b8hyyr	2489	7	should	should	MD
cord-006860-a3b8hyyr	2489	8	be	be	VB
cord-006860-a3b8hyyr	2489	9	compulsory	compulsory	JJ
cord-006860-a3b8hyyr	2489	10	for	for	IN
cord-006860-a3b8hyyr	2489	11	the	the	DT
cord-006860-a3b8hyyr	2489	12	choosing	choosing	NN
cord-006860-a3b8hyyr	2489	13	of	of	IN
cord-006860-a3b8hyyr	2489	14	the	the	DT
cord-006860-a3b8hyyr	2489	15	aPTT	aptt	JJ
cord-006860-a3b8hyyr	2489	16	reagent	reagent	NN
cord-006860-a3b8hyyr	2489	17	.	.	.
cord-006860-a3b8hyyr	2490	1	Introduction	introduction	NN
cord-006860-a3b8hyyr	2490	2	:	:	:
cord-006860-a3b8hyyr	2490	3	HAT	hat	NN
cord-006860-a3b8hyyr	2490	4	is	be	VBZ
cord-006860-a3b8hyyr	2490	5	a	a	DT
cord-006860-a3b8hyyr	2490	6	rare	rare	JJ
cord-006860-a3b8hyyr	2490	7	but	but	CC
cord-006860-a3b8hyyr	2490	8	sometimes	sometimes	RB
cord-006860-a3b8hyyr	2490	9	fatal	fatal	JJ
cord-006860-a3b8hyyr	2490	10	complication	complication	NN
cord-006860-a3b8hyyr	2490	11	of	of	IN
cord-006860-a3b8hyyr	2490	12	therapy	therapy	NN
cord-006860-a3b8hyyr	2490	13	with	with	IN
cord-006860-a3b8hyyr	2490	14	unfractionated	unfractionated	JJ
cord-006860-a3b8hyyr	2490	15	(	(	-LRB-
cord-006860-a3b8hyyr	2490	16	UFH	UFH	NNP
cord-006860-a3b8hyyr	2490	17	)	)	-RRB-
cord-006860-a3b8hyyr	2490	18	and	and	CC
cord-006860-a3b8hyyr	2490	19	low	low	JJ
cord-006860-a3b8hyyr	2490	20	molecular	molecular	JJ
cord-006860-a3b8hyyr	2490	21	weight	weight	NN
cord-006860-a3b8hyyr	2490	22	beparins	beparin	NNS
cord-006860-a3b8hyyr	2490	23	(	(	-LRB-
cord-006860-a3b8hyyr	2490	24	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2490	25	)	)	-RRB-
cord-006860-a3b8hyyr	2490	26	.	.	.
cord-006860-a3b8hyyr	2491	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2491	2	report	report	VBP
cord-006860-a3b8hyyr	2491	3	on	on	IN
cord-006860-a3b8hyyr	2491	4	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2491	5	experience	experience	NN
cord-006860-a3b8hyyr	2491	6	with	with	IN
cord-006860-a3b8hyyr	2491	7	the	the	DT
cord-006860-a3b8hyyr	2491	8	clinical	clinical	JJ
cord-006860-a3b8hyyr	2491	9	coume	coume	NN
cord-006860-a3b8hyyr	2491	10	and	and	CC
cord-006860-a3b8hyyr	2491	11	management	management	NN
cord-006860-a3b8hyyr	2491	12	in	in	IN
cord-006860-a3b8hyyr	2491	13	12	12	CD
cord-006860-a3b8hyyr	2491	14	patients	patient	NNS
cord-006860-a3b8hyyr	2491	15	(	(	-LRB-
cord-006860-a3b8hyyr	2491	16	pts	pts	NNP
cord-006860-a3b8hyyr	2491	17	)	)	-RRB-
cord-006860-a3b8hyyr	2491	18	.	.	.
cord-006860-a3b8hyyr	2492	1	In	in	IN
cord-006860-a3b8hyyr	2492	2	all	all	DT
cord-006860-a3b8hyyr	2492	3	cases	case	NNS
cord-006860-a3b8hyyr	2492	4	a	a	DT
cord-006860-a3b8hyyr	2492	5	severe	severe	JJ
cord-006860-a3b8hyyr	2492	6	decline	decline	NN
cord-006860-a3b8hyyr	2492	7	of	of	IN
cord-006860-a3b8hyyr	2492	8	platelet	platelet	NN
cord-006860-a3b8hyyr	2492	9	count	count	NN
cord-006860-a3b8hyyr	2492	10	and	and	CC
cord-006860-a3b8hyyr	2492	11	in	in	IN
cord-006860-a3b8hyyr	2492	12	11	11	CD
cord-006860-a3b8hyyr	2492	13	cases	case	NNS
cord-006860-a3b8hyyr	2492	14	a	a	DT
cord-006860-a3b8hyyr	2492	15	positive	positive	JJ
cord-006860-a3b8hyyr	2492	16	HIPA	HIPA	NNP
cord-006860-a3b8hyyr	2492	17	test	test	NN
cord-006860-a3b8hyyr	2492	18	(=	(=	-LRB-
cord-006860-a3b8hyyr	2492	19	heparin	heparin	NN
cord-006860-a3b8hyyr	2492	20	-	-	HYPH
cord-006860-a3b8hyyr	2492	21	induced	induce	VBN
cord-006860-a3b8hyyr	2492	22	platelet	platelet	NN
cord-006860-a3b8hyyr	2492	23	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2492	24	)	)	-RRB-
cord-006860-a3b8hyyr	2492	25	were	be	VBD
cord-006860-a3b8hyyr	2492	26	documented	document	VBN
cord-006860-a3b8hyyr	2492	27	.	.	.
cord-006860-a3b8hyyr	2493	1	Patients	patient	NNS
cord-006860-a3b8hyyr	2493	2	,	,	,
cord-006860-a3b8hyyr	2493	3	clinical	clinical	JJ
cord-006860-a3b8hyyr	2493	4	course	course	NN
cord-006860-a3b8hyyr	2493	5	and	and	CC
cord-006860-a3b8hyyr	2493	6	outcome	outcome	NN
cord-006860-a3b8hyyr	2493	7	:	:	:
cord-006860-a3b8hyyr	2493	8	8	8	CD
cord-006860-a3b8hyyr	2493	9	female	female	NN
cord-006860-a3b8hyyr	2493	10	and	and	CC
cord-006860-a3b8hyyr	2493	11	4	4	CD
cord-006860-a3b8hyyr	2493	12	male	male	JJ
cord-006860-a3b8hyyr	2493	13	patients	patient	NNS
cord-006860-a3b8hyyr	2493	14	(	(	-LRB-
cord-006860-a3b8hyyr	2493	15	median	median	JJ
cord-006860-a3b8hyyr	2493	16	age	age	NN
cord-006860-a3b8hyyr	2493	17	68	68	CD
cord-006860-a3b8hyyr	2493	18	years	year	NNS
cord-006860-a3b8hyyr	2493	19	,	,	,
cord-006860-a3b8hyyr	2493	20	range	range	VBP
cord-006860-a3b8hyyr	2493	21	22	22	CD
cord-006860-a3b8hyyr	2493	22	-	-	SYM
cord-006860-a3b8hyyr	2493	23	78	78	CD
cord-006860-a3b8hyyr	2493	24	)	)	-RRB-
cord-006860-a3b8hyyr	2493	25	were	be	VBD
cord-006860-a3b8hyyr	2493	26	analysed	analyse	VBN
cord-006860-a3b8hyyr	2493	27	in	in	IN
cord-006860-a3b8hyyr	2493	28	this	this	DT
cord-006860-a3b8hyyr	2493	29	retrospective	retrospective	JJ
cord-006860-a3b8hyyr	2493	30	study	study	NN
cord-006860-a3b8hyyr	2493	31	.	.	.
cord-006860-a3b8hyyr	2494	1	9	9	CD
cord-006860-a3b8hyyr	2494	2	pts	pt	NNS
cord-006860-a3b8hyyr	2494	3	were	be	VBD
cord-006860-a3b8hyyr	2494	4	referred	refer	VBN
cord-006860-a3b8hyyr	2494	5	from	from	IN
cord-006860-a3b8hyyr	2494	6	outside	outside	JJ
cord-006860-a3b8hyyr	2494	7	hospitals	hospital	NNS
cord-006860-a3b8hyyr	2494	8	.	.	.
cord-006860-a3b8hyyr	2495	1	All	all	DT
cord-006860-a3b8hyyr	2495	2	pts	pts	NN
cord-006860-a3b8hyyr	2495	3	had	have	VBD
cord-006860-a3b8hyyr	2495	4	been	be	VBN
cord-006860-a3b8hyyr	2495	5	treated	treat	VBN
cord-006860-a3b8hyyr	2495	6	with	with	IN
cord-006860-a3b8hyyr	2495	7	UFH	UFH	NNP
cord-006860-a3b8hyyr	2495	8	(	(	-LRB-
cord-006860-a3b8hyyr	2495	9	5	5	CD
cord-006860-a3b8hyyr	2495	10	pts	pts	NN
cord-006860-a3b8hyyr	2495	11	additionally	additionally	RB
cord-006860-a3b8hyyr	2495	12	with	with	IN
cord-006860-a3b8hyyr	2495	13	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2495	14	)	)	-RRB-
cord-006860-a3b8hyyr	2495	15	for	for	IN
cord-006860-a3b8hyyr	2495	16	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2495	17	(	(	-LRB-
cord-006860-a3b8hyyr	2495	18	n	n	NN
cord-006860-a3b8hyyr	2495	19	=	=	SYM
cord-006860-a3b8hyyr	2495	20	9	9	CD
cord-006860-a3b8hyyr	2495	21	.	.	.
cord-006860-a3b8hyyr	2496	1	in	in	IN
cord-006860-a3b8hyyr	2496	2	2	2	CD
cord-006860-a3b8hyyr	2496	3	pts	pt	NNS
cord-006860-a3b8hyyr	2496	4	pedoperatively	pedoperatively	NNP
cord-006860-a3b8hyyr	2496	5	)	)	-RRB-
cord-006860-a3b8hyyr	2496	6	or	or	CC
cord-006860-a3b8hyyr	2496	7	treatment	treatment	NN
cord-006860-a3b8hyyr	2496	8	(	(	-LRB-
cord-006860-a3b8hyyr	2496	9	n	n	NN
cord-006860-a3b8hyyr	2496	10	=	=	SYM
cord-006860-a3b8hyyr	2496	11	3	3	CD
cord-006860-a3b8hyyr	2496	12	)	)	-RRB-
cord-006860-a3b8hyyr	2496	13	of	of	IN
cord-006860-a3b8hyyr	2496	14	venous	venous	JJ
cord-006860-a3b8hyyr	2496	15	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	2496	16	(	(	-LRB-
cord-006860-a3b8hyyr	2496	17	V'TE	v'te	NN
cord-006860-a3b8hyyr	2496	18	)	)	-RRB-
cord-006860-a3b8hyyr	2496	19	.	.	.
cord-006860-a3b8hyyr	2497	1	In	in	IN
cord-006860-a3b8hyyr	2497	2	11	11	CD
cord-006860-a3b8hyyr	2497	3	pts	pt	NNS
cord-006860-a3b8hyyr	2497	4	at	at	IN
cord-006860-a3b8hyyr	2497	5	least	least	RBS
cord-006860-a3b8hyyr	2497	6	one	one	CD
cord-006860-a3b8hyyr	2497	7	VTE	VTE	NNP
cord-006860-a3b8hyyr	2497	8	occured	occur	VBD
cord-006860-a3b8hyyr	2497	9	during	during	IN
cord-006860-a3b8hyyr	2497	10	heparin	heparin	NN
cord-006860-a3b8hyyr	2497	11	therapy	therapy	NN
cord-006860-a3b8hyyr	2497	12	,	,	,
cord-006860-a3b8hyyr	2497	13	in	in	IN
cord-006860-a3b8hyyr	2497	14	all	all	DT
cord-006860-a3b8hyyr	2497	15	cases	case	NNS
cord-006860-a3b8hyyr	2497	16	prior	prior	RB
cord-006860-a3b8hyyr	2497	17	to	to	IN
cord-006860-a3b8hyyr	2497	18	HAT	hat	NN
cord-006860-a3b8hyyr	2497	19	-	-	HYPH
cord-006860-a3b8hyyr	2497	20	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	2497	21	(	(	-LRB-
cord-006860-a3b8hyyr	2497	22	VTE	VTE	NNP
cord-006860-a3b8hyyr	2497	23	:	:	:
cord-006860-a3b8hyyr	2498	1	n	n	NN
cord-006860-a3b8hyyr	2498	2	=	=	SYM
cord-006860-a3b8hyyr	2498	3	13	13	CD
cord-006860-a3b8hyyr	2498	4	;	;	:
cord-006860-a3b8hyyr	2498	5	putmonary	putmonary	NNP
cord-006860-a3b8hyyr	2498	6	embolism	embolism	NN
cord-006860-a3b8hyyr	2498	7	:	:	:
cord-006860-a3b8hyyr	2499	1	n	n	NN
cord-006860-a3b8hyyr	2499	2	=	=	SYM
cord-006860-a3b8hyyr	2499	3	6	6	CD
cord-006860-a3b8hyyr	2499	4	;	;	,
cord-006860-a3b8hyyr	2499	5	artenal	artenal	NNP
cord-006860-a3b8hyyr	2499	6	embolism	embolism	NN
cord-006860-a3b8hyyr	2499	7	n	n	CC
cord-006860-a3b8hyyr	2499	8	=	=	SYM
cord-006860-a3b8hyyr	2499	9	1	1	CD
cord-006860-a3b8hyyr	2499	10	;	;	:
cord-006860-a3b8hyyr	2499	11	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2499	12	of	of	IN
cord-006860-a3b8hyyr	2499	13	sinus	sinus	NNP
cord-006860-a3b8hyyr	2499	14	transversus	transversus	NNP
cord-006860-a3b8hyyr	2499	15	n	n	NN
cord-006860-a3b8hyyr	2499	16	=	=	SYM
cord-006860-a3b8hyyr	2499	17	1	1	CD
cord-006860-a3b8hyyr	2499	18	)	)	-RRB-
cord-006860-a3b8hyyr	2499	19	.	.	.
cord-006860-a3b8hyyr	2500	1	HAT	HAT	NNP
cord-006860-a3b8hyyr	2500	2	was	be	VBD
cord-006860-a3b8hyyr	2500	3	suspected	suspect	VBN
cord-006860-a3b8hyyr	2500	4	16.5	16.5	CD
cord-006860-a3b8hyyr	2500	5	days	day	NNS
cord-006860-a3b8hyyr	2500	6	(	(	-LRB-
cord-006860-a3b8hyyr	2500	7	median	median	NN
cord-006860-a3b8hyyr	2500	8	;	;	:
cord-006860-a3b8hyyr	2500	9	range	range	NN
cord-006860-a3b8hyyr	2500	10	12	12	CD
cord-006860-a3b8hyyr	2500	11	-48	-48	NNS
cord-006860-a3b8hyyr	2500	12	)	)	-RRB-
cord-006860-a3b8hyyr	2500	13	after	after	IN
cord-006860-a3b8hyyr	2500	14	first	first	JJ
cord-006860-a3b8hyyr	2500	15	heparin	heparin	NN
cord-006860-a3b8hyyr	2500	16	application	application	NN
cord-006860-a3b8hyyr	2500	17	.	.	.
cord-006860-a3b8hyyr	2501	1	Hepadn	Hepadn	NNP
cord-006860-a3b8hyyr	2501	2	therapy	therapy	NN
cord-006860-a3b8hyyr	2501	3	was	be	VBD
cord-006860-a3b8hyyr	2501	4	discontinued	discontinue	VBN
cord-006860-a3b8hyyr	2501	5	immediately	immediately	RB
cord-006860-a3b8hyyr	2501	6	,	,	,
cord-006860-a3b8hyyr	2501	7	At	at	IN
cord-006860-a3b8hyyr	2501	8	that	that	DT
cord-006860-a3b8hyyr	2501	9	time	time	NN
cord-006860-a3b8hyyr	2501	10	the	the	DT
cord-006860-a3b8hyyr	2501	11	median	median	JJ
cord-006860-a3b8hyyr	2501	12	plateiet	plateiet	NNP
cord-006860-a3b8hyyr	2501	13	count	count	NNP
cord-006860-a3b8hyyr	2501	14	was	be	VBD
cord-006860-a3b8hyyr	2501	15	35	35	CD
cord-006860-a3b8hyyr	2501	16	G	g	NN
cord-006860-a3b8hyyr	2501	17	/	/	SYM
cord-006860-a3b8hyyr	2501	18	I	-PRON-	PRP
cord-006860-a3b8hyyr	2501	19	(	(	-LRB-
cord-006860-a3b8hyyr	2501	20	range	range	VBP
cord-006860-a3b8hyyr	2501	21	10	10	CD
cord-006860-a3b8hyyr	2501	22	-117	-117	NN
cord-006860-a3b8hyyr	2501	23	)	)	-RRB-
cord-006860-a3b8hyyr	2501	24	.	.	.
cord-006860-a3b8hyyr	2502	1	9	9	CD
cord-006860-a3b8hyyr	2502	2	pts	pt	NNS
cord-006860-a3b8hyyr	2502	3	were	be	VBD
cord-006860-a3b8hyyr	2502	4	treated	treat	VBN
cord-006860-a3b8hyyr	2502	5	with	with	IN
cord-006860-a3b8hyyr	2502	6	Orgaran	Orgaran	NNP
cord-006860-a3b8hyyr	2502	7	R	r	NN
cord-006860-a3b8hyyr	2502	8	,	,	,
cord-006860-a3b8hyyr	2502	9	followed	follow	VBN
cord-006860-a3b8hyyr	2502	10	by	by	IN
cord-006860-a3b8hyyr	2502	11	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	2502	12	hirudin	hirudin	NNP
cord-006860-a3b8hyyr	2502	13	(	(	-LRB-
cord-006860-a3b8hyyr	2502	14	r	r	NN
cord-006860-a3b8hyyr	2502	15	-	-	HYPH
cord-006860-a3b8hyyr	2502	16	hirudin	hirudin	NN
cord-006860-a3b8hyyr	2502	17	,	,	,
cord-006860-a3b8hyyr	2502	18	Behdngwerke	Behdngwerke	NNP
cord-006860-a3b8hyyr	2502	19	AG	AG	NNP
cord-006860-a3b8hyyr	2502	20	:	:	:
cord-006860-a3b8hyyr	2502	21	clinical	clinical	JJ
cord-006860-a3b8hyyr	2502	22	study	study	NN
cord-006860-a3b8hyyr	2502	23	)	)	-RRB-
cord-006860-a3b8hyyr	2502	24	in	in	IN
cord-006860-a3b8hyyr	2502	25	4	4	CD
cord-006860-a3b8hyyr	2502	26	cases	case	NNS
cord-006860-a3b8hyyr	2502	27	;	;	:
cord-006860-a3b8hyyr	2502	28	3	3	CD
cord-006860-a3b8hyyr	2502	29	pts	pt	NNS
cord-006860-a3b8hyyr	2502	30	were	be	VBD
cord-006860-a3b8hyyr	2502	31	treated	treat	VBN
cord-006860-a3b8hyyr	2502	32	exclusively	exclusively	RB
cord-006860-a3b8hyyr	2502	33	with	with	IN
cord-006860-a3b8hyyr	2502	34	r	r	NN
cord-006860-a3b8hyyr	2502	35	-	-	:
cord-006860-a3b8hyyr	2502	36	hirudin	hirudin	NN
cord-006860-a3b8hyyr	2502	37	.	.	.
cord-006860-a3b8hyyr	2503	1	Plat	Plat	NNP
cord-006860-a3b8hyyr	2503	2	~	~	NFP
cord-006860-a3b8hyyr	2503	3	let	let	VBD
cord-006860-a3b8hyyr	2503	4	count	count	VB
cord-006860-a3b8hyyr	2503	5	normalized	normalize	VBN
cord-006860-a3b8hyyr	2503	6	in	in	IN
cord-006860-a3b8hyyr	2503	7	9	9	CD
cord-006860-a3b8hyyr	2503	8	pts	pt	NNS
cord-006860-a3b8hyyr	2503	9	within	within	IN
cord-006860-a3b8hyyr	2503	10	3	3	CD
cord-006860-a3b8hyyr	2503	11	days	day	NNS
cord-006860-a3b8hyyr	2503	12	(	(	-LRB-
cord-006860-a3b8hyyr	2503	13	median	median	NN
cord-006860-a3b8hyyr	2503	14	;	;	.
cord-006860-a3b8hyyr	2504	1	range	range	NNP
cord-006860-a3b8hyyr	2504	2	1	1	CD
cord-006860-a3b8hyyr	2504	3	-	-	SYM
cord-006860-a3b8hyyr	2504	4	10	10	CD
cord-006860-a3b8hyyr	2504	5	)	)	-RRB-
cord-006860-a3b8hyyr	2504	6	.	.	.
cord-006860-a3b8hyyr	2505	1	One	one	CD
cord-006860-a3b8hyyr	2505	2	patient	patient	NN
cord-006860-a3b8hyyr	2505	3	in	in	IN
cord-006860-a3b8hyyr	2505	4	the	the	DT
cord-006860-a3b8hyyr	2505	5	Orgaran	Orgaran	NNP
cord-006860-a3b8hyyr	2505	6	"	"	''
cord-006860-a3b8hyyr	2505	7	group	group	NN
cord-006860-a3b8hyyr	2505	8	died	die	VBD
cord-006860-a3b8hyyr	2505	9	on	on	IN
cord-006860-a3b8hyyr	2505	10	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	2505	11	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	2505	12	embolism	embolism	NN
cord-006860-a3b8hyyr	2505	13	.	.	.
cord-006860-a3b8hyyr	2506	1	11	11	CD
cord-006860-a3b8hyyr	2506	2	pts	pt	NNS
cord-006860-a3b8hyyr	2506	3	recovered	recover	VBN
cord-006860-a3b8hyyr	2506	4	without	without	IN
cord-006860-a3b8hyyr	2506	5	any	any	DT
cord-006860-a3b8hyyr	2506	6	further	further	JJ
cord-006860-a3b8hyyr	2506	7	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	2506	8	complication	complication	NN
cord-006860-a3b8hyyr	2506	9	.	.	.
cord-006860-a3b8hyyr	2507	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	2507	2	:	:	:
cord-006860-a3b8hyyr	2508	1	In	in	IN
cord-006860-a3b8hyyr	2508	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2508	3	small	small	JJ
cord-006860-a3b8hyyr	2508	4	series	series	NN
cord-006860-a3b8hyyr	2508	5	of	of	IN
cord-006860-a3b8hyyr	2508	6	10ts	10ts	JJ
cord-006860-a3b8hyyr	2508	7	HAT	HAT	NNP
cord-006860-a3b8hyyr	2508	8	was	be	VBD
cord-006860-a3b8hyyr	2508	9	complicated	complicate	VBN
cord-006860-a3b8hyyr	2508	10	with	with	IN
cord-006860-a3b8hyyr	2508	11	VTE	VTE	NNP
cord-006860-a3b8hyyr	2508	12	in	in	IN
cord-006860-a3b8hyyr	2508	13	11/12	11/12	CD
cord-006860-a3b8hyyr	2508	14	cases	case	NNS
cord-006860-a3b8hyyr	2508	15	.	.	.
cord-006860-a3b8hyyr	2509	1	In	in	IN
cord-006860-a3b8hyyr	2509	2	many	many	JJ
cord-006860-a3b8hyyr	2509	3	pts	pt	NNS
cord-006860-a3b8hyyr	2509	4	HAT	hat	NN
cord-006860-a3b8hyyr	2509	5	was	be	VBD
cord-006860-a3b8hyyr	2509	6	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	2509	7	strikingly	strikingly	RB
cord-006860-a3b8hyyr	2509	8	late	late	RB
cord-006860-a3b8hyyr	2509	9	.	.	.
cord-006860-a3b8hyyr	2510	1	For	for	IN
cord-006860-a3b8hyyr	2510	2	early	early	JJ
cord-006860-a3b8hyyr	2510	3	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	2510	4	careful	careful	JJ
cord-006860-a3b8hyyr	2510	5	monitonng	monitonng	NN
cord-006860-a3b8hyyr	2510	6	of	of	IN
cord-006860-a3b8hyyr	2510	7	platelet	platelet	NN
cord-006860-a3b8hyyr	2510	8	counts	count	NNS
cord-006860-a3b8hyyr	2510	9	are	be	VBP
cord-006860-a3b8hyyr	2510	10	mandatory	mandatory	JJ
cord-006860-a3b8hyyr	2510	11	dunng	dunng	JJ
cord-006860-a3b8hyyr	2510	12	hepadn	hepadn	JJ
cord-006860-a3b8hyyr	2510	13	therapy	therapy	NN
cord-006860-a3b8hyyr	2510	14	,	,	,
cord-006860-a3b8hyyr	2510	15	Both	both	CC
cord-006860-a3b8hyyr	2510	16	Orgaran	Orgaran	NNP
cord-006860-a3b8hyyr	2510	17	~	~	NFP
cord-006860-a3b8hyyr	2510	18	and	and	CC
cord-006860-a3b8hyyr	2511	1	r	r	LS
cord-006860-a3b8hyyr	2511	2	-	-	:
cord-006860-a3b8hyyr	2511	3	hirudin	hirudin	NN
cord-006860-a3b8hyyr	2511	4	seem	seem	VBP
cord-006860-a3b8hyyr	2511	5	to	to	TO
cord-006860-a3b8hyyr	2511	6	be	be	VB
cord-006860-a3b8hyyr	2511	7	safe	safe	JJ
cord-006860-a3b8hyyr	2511	8	and	and	CC
cord-006860-a3b8hyyr	2511	9	effective	effective	JJ
cord-006860-a3b8hyyr	2511	10	in	in	IN
cord-006860-a3b8hyyr	2511	11	preventing	prevent	VBG
cord-006860-a3b8hyyr	2511	12	further	further	JJ
cord-006860-a3b8hyyr	2511	13	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	2511	14	,	,	,
cord-006860-a3b8hyyr	2511	15	P	p	NN
cord-006860-a3b8hyyr	2511	16	179	179	CD
cord-006860-a3b8hyyr	2512	1	To	to	TO
cord-006860-a3b8hyyr	2512	2	prospectively	prospectively	RB
cord-006860-a3b8hyyr	2512	3	evaluate	evaluate	VB
cord-006860-a3b8hyyr	2512	4	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2512	5	or	or	CC
cord-006860-a3b8hyyr	2512	6	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	2512	7	activation	activation	NN
cord-006860-a3b8hyyr	2512	8	in	in	IN
cord-006860-a3b8hyyr	2512	9	children	child	NNS
cord-006860-a3b8hyyr	2512	10	long	long	JJ
cord-006860-a3b8hyyr	2512	11	-	-	HYPH
cord-006860-a3b8hyyr	2512	12	term	term	NN
cord-006860-a3b8hyyr	2512	13	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	2512	14	with	with	IN
cord-006860-a3b8hyyr	2512	15	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2512	16	was	be	VBD
cord-006860-a3b8hyyr	2512	17	administered	administer	VBN
cord-006860-a3b8hyyr	2512	18	a	a	DT
cord-006860-a3b8hyyr	2512	19	longitudinal	longitudinal	JJ
cord-006860-a3b8hyyr	2512	20	study	study	NN
cord-006860-a3b8hyyr	2512	21	was	be	VBD
cord-006860-a3b8hyyr	2512	22	perfomed	perfome	VBN
cord-006860-a3b8hyyr	2512	23	.	.	.
cord-006860-a3b8hyyr	2513	1	Within	within	IN
cord-006860-a3b8hyyr	2513	2	a	a	DT
cord-006860-a3b8hyyr	2513	3	30	30	CD
cord-006860-a3b8hyyr	2513	4	months	month	NNS
cord-006860-a3b8hyyr	2513	5	period	period	NN
cord-006860-a3b8hyyr	2513	6	48	48	CD
cord-006860-a3b8hyyr	2513	7	children	child	NNS
cord-006860-a3b8hyyr	2513	8	and	and	CC
cord-006860-a3b8hyyr	2513	9	adolescents	adolescent	NNS
cord-006860-a3b8hyyr	2513	10	(	(	-LRB-
cord-006860-a3b8hyyr	2513	11	6	6	CD
cord-006860-a3b8hyyr	2513	12	-19	-19	NN
cord-006860-a3b8hyyr	2513	13	years	year	NNS
cord-006860-a3b8hyyr	2513	14	)	)	-RRB-
cord-006860-a3b8hyyr	2513	15	suffering	suffer	VBG
cord-006860-a3b8hyyr	2513	16	from	from	IN
cord-006860-a3b8hyyr	2513	17	malignant	malignant	JJ
cord-006860-a3b8hyyr	2513	18	bone	bone	NN
cord-006860-a3b8hyyr	2513	19	tumors	tumor	NNS
cord-006860-a3b8hyyr	2513	20	(	(	-LRB-
cord-006860-a3b8hyyr	2513	21	Ewing	Ewing	NNP
cord-006860-a3b8hyyr	2513	22	's	's	POS
cord-006860-a3b8hyyr	2513	23	sarcoma	sarcoma	NN
cord-006860-a3b8hyyr	2513	24	or	or	CC
cord-006860-a3b8hyyr	2513	25	osteosarcoma	osteosarcoma	NN
cord-006860-a3b8hyyr	2513	26	)	)	-RRB-
cord-006860-a3b8hyyr	2513	27	received	receive	VBD
cord-006860-a3b8hyyr	2513	28	Enoxaparin	Enoxaparin	NNP
cord-006860-a3b8hyyr	2513	29	(	(	-LRB-
cord-006860-a3b8hyyr	2513	30	Clexane	Clexane	NNP
cord-006860-a3b8hyyr	2513	31	R	R	NNP
cord-006860-a3b8hyyr	2513	32	/	/	SYM
cord-006860-a3b8hyyr	2513	33	Rhone	Rhone	NNP
cord-006860-a3b8hyyr	2513	34	-	-	HYPH
cord-006860-a3b8hyyr	2513	35	Poulenc	Poulenc	NNP
cord-006860-a3b8hyyr	2513	36	Rorer	Rorer	NNP
cord-006860-a3b8hyyr	2513	37	,	,	,
cord-006860-a3b8hyyr	2513	38	France	France	NNP
cord-006860-a3b8hyyr	2513	39	)	)	-RRB-
cord-006860-a3b8hyyr	2513	40	for	for	IN
cord-006860-a3b8hyyr	2513	41	primary	primary	JJ
cord-006860-a3b8hyyr	2513	42	propylaMs	propylaMs	NNP
cord-006860-a3b8hyyr	2513	43	.	.	.
cord-006860-a3b8hyyr	2514	1	The	the	DT
cord-006860-a3b8hyyr	2514	2	majority	majority	NN
cord-006860-a3b8hyyr	2514	3	of	of	IN
cord-006860-a3b8hyyr	2514	4	patients	patient	NNS
cord-006860-a3b8hyyr	2514	5	received	receive	VBD
cord-006860-a3b8hyyr	2514	6	0.6	0.6	CD
cord-006860-a3b8hyyr	2514	7	mg	mg	NNP
cord-006860-a3b8hyyr	2514	8	/	/	SYM
cord-006860-a3b8hyyr	2514	9	kg	kg	NNP
cord-006860-a3b8hyyr	2514	10	bw	bw	NNP
cord-006860-a3b8hyyr	2514	11	Enoxaparin	Enoxaparin	NNP
cord-006860-a3b8hyyr	2514	12	12	12	CD
cord-006860-a3b8hyyr	2514	13	hours	hour	NNS
cord-006860-a3b8hyyr	2514	14	before	before	IN
cord-006860-a3b8hyyr	2514	15	major	major	JJ
cord-006860-a3b8hyyr	2514	16	surgery	surgery	NN
cord-006860-a3b8hyyr	2514	17	(	(	-LRB-
cord-006860-a3b8hyyr	2514	18	limb	limb	NN
cord-006860-a3b8hyyr	2514	19	salavage	salavage	NN
cord-006860-a3b8hyyr	2514	20	)	)	-RRB-
cord-006860-a3b8hyyr	2514	21	.	.	.
cord-006860-a3b8hyyr	2515	1	In	in	IN
cord-006860-a3b8hyyr	2515	2	addition	addition	NN
cord-006860-a3b8hyyr	2515	3	,	,	,
cord-006860-a3b8hyyr	2515	4	ten	ten	CD
cord-006860-a3b8hyyr	2515	5	neonates	neonate	NNS
cord-006860-a3b8hyyr	2515	6	and	and	CC
cord-006860-a3b8hyyr	2515	7	children	child	NNS
cord-006860-a3b8hyyr	2515	8	received	receive	VBD
cord-006860-a3b8hyyr	2515	9	Enoxaparin	Enoxaparin	NNP
cord-006860-a3b8hyyr	2515	10	in	in	IN
cord-006860-a3b8hyyr	2515	11	the	the	DT
cord-006860-a3b8hyyr	2515	12	same	same	JJ
cord-006860-a3b8hyyr	2515	13	dosage	dosage	NN
cord-006860-a3b8hyyr	2515	14	for	for	IN
cord-006860-a3b8hyyr	2515	15	secondary	secondary	JJ
cord-006860-a3b8hyyr	2515	16	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2515	17	.	.	.
cord-006860-a3b8hyyr	2516	1	In	in	IN
cord-006860-a3b8hyyr	2516	2	both	both	DT
cord-006860-a3b8hyyr	2516	3	groups	group	NNS
cord-006860-a3b8hyyr	2516	4	therapy	therapy	NN
cord-006860-a3b8hyyr	2516	5	was	be	VBD
cord-006860-a3b8hyyr	2516	6	adjusted	adjust	VBN
cord-006860-a3b8hyyr	2516	7	to	to	IN
cord-006860-a3b8hyyr	2516	8	0.2	0.2	CD
cord-006860-a3b8hyyr	2516	9	-0.4	-0.4	CD
cord-006860-a3b8hyyr	2516	10	IU	IU	NNP
cord-006860-a3b8hyyr	2516	11	/	/	,
cord-006860-a3b8hyyr	2516	12	ml	ml	CC
cord-006860-a3b8hyyr	2516	13	anti	anti	JJ
cord-006860-a3b8hyyr	2516	14	Xa	Xa	NNP
cord-006860-a3b8hyyr	2516	15	activity	activity	NN
cord-006860-a3b8hyyr	2516	16	.	.	.
cord-006860-a3b8hyyr	2517	1	Median	median	JJ
cord-006860-a3b8hyyr	2517	2	(	(	-LRB-
cord-006860-a3b8hyyr	2517	3	range	range	NN
cord-006860-a3b8hyyr	2517	4	)	)	-RRB-
cord-006860-a3b8hyyr	2517	5	duration	duration	NN
cord-006860-a3b8hyyr	2517	6	of	of	IN
cord-006860-a3b8hyyr	2517	7	therapy	therapy	NN
cord-006860-a3b8hyyr	2517	8	was	be	VBD
cord-006860-a3b8hyyr	2517	9	performed	perform	VBN
cord-006860-a3b8hyyr	2517	10	for	for	IN
cord-006860-a3b8hyyr	2517	11	l0	l0	NNP
cord-006860-a3b8hyyr	2517	12	(	(	-LRB-
cord-006860-a3b8hyyr	2517	13	6	6	CD
cord-006860-a3b8hyyr	2517	14	-24	-24	NN
cord-006860-a3b8hyyr	2517	15	)	)	-RRB-
cord-006860-a3b8hyyr	2517	16	weeks	week	NNS
cord-006860-a3b8hyyr	2517	17	.	.	.
cord-006860-a3b8hyyr	2518	1	Before	before	IN
cord-006860-a3b8hyyr	2518	2	(	(	-LRB-
cord-006860-a3b8hyyr	2518	3	'	'	``
cord-006860-a3b8hyyr	2518	4	1"1	1"1	CD
cord-006860-a3b8hyyr	2518	5	)	)	-RRB-
cord-006860-a3b8hyyr	2518	6	,	,	,
cord-006860-a3b8hyyr	2518	7	one	one	CD
cord-006860-a3b8hyyr	2518	8	(	(	-LRB-
cord-006860-a3b8hyyr	2518	9	T2	T2	NNP
cord-006860-a3b8hyyr	2518	10	)	)	-RRB-
cord-006860-a3b8hyyr	2518	11	and	and	CC
cord-006860-a3b8hyyr	2518	12	3	3	CD
cord-006860-a3b8hyyr	2518	13	weeks	week	NNS
cord-006860-a3b8hyyr	2518	14	(	(	-LRB-
cord-006860-a3b8hyyr	2518	15	T3	T3	NNP
cord-006860-a3b8hyyr	2518	16	)	)	-RRB-
cord-006860-a3b8hyyr	2519	1	Within	within	IN
cord-006860-a3b8hyyr	2519	2	the	the	DT
cord-006860-a3b8hyyr	2519	3	context	context	NN
cord-006860-a3b8hyyr	2519	4	of	of	IN
cord-006860-a3b8hyyr	2519	5	the	the	DT
cord-006860-a3b8hyyr	2519	6	present	present	JJ
cord-006860-a3b8hyyr	2519	7	study	study	NN
cord-006860-a3b8hyyr	2519	8	an	an	DT
cord-006860-a3b8hyyr	2519	9	investigation	investigation	NN
cord-006860-a3b8hyyr	2519	10	on	on	IN
cord-006860-a3b8hyyr	2519	11	the	the	DT
cord-006860-a3b8hyyr	2519	12	physiology	physiology	NN
cord-006860-a3b8hyyr	2519	13	of	of	IN
cord-006860-a3b8hyyr	2519	14	clotting	clotting	NN
cord-006860-a3b8hyyr	2519	15	was	be	VBD
cord-006860-a3b8hyyr	2519	16	conducted	conduct	VBN
cord-006860-a3b8hyyr	2519	17	in	in	IN
cord-006860-a3b8hyyr	2519	18	three	three	CD
cord-006860-a3b8hyyr	2519	19	groups	group	NNS
cord-006860-a3b8hyyr	2519	20	each	each	DT
cord-006860-a3b8hyyr	2519	21	consisting	consist	VBG
cord-006860-a3b8hyyr	2519	22	of	of	IN
cord-006860-a3b8hyyr	2519	23	12	12	CD
cord-006860-a3b8hyyr	2519	24	patients	patient	NNS
cord-006860-a3b8hyyr	2519	25	,	,	,
cord-006860-a3b8hyyr	2519	26	who	who	WP
cord-006860-a3b8hyyr	2519	27	had	have	VBD
cord-006860-a3b8hyyr	2519	28	to	to	TO
cord-006860-a3b8hyyr	2519	29	undergo	undergo	VB
cord-006860-a3b8hyyr	2519	30	a	a	DT
cord-006860-a3b8hyyr	2519	31	total	total	JJ
cord-006860-a3b8hyyr	2519	32	end	end	NN
cord-006860-a3b8hyyr	2519	33	-	-	HYPH
cord-006860-a3b8hyyr	2519	34	prosthetic	prosthetic	JJ
cord-006860-a3b8hyyr	2519	35	hip	hip	NN
cord-006860-a3b8hyyr	2519	36	implantation	implantation	NN
cord-006860-a3b8hyyr	2519	37	(	(	-LRB-
cord-006860-a3b8hyyr	2519	38	TEPH	TEPH	NNP
cord-006860-a3b8hyyr	2519	39	)	)	-RRB-
cord-006860-a3b8hyyr	2519	40	for	for	IN
cord-006860-a3b8hyyr	2519	41	the	the	DT
cord-006860-a3b8hyyr	2519	42	first	first	JJ
cord-006860-a3b8hyyr	2519	43	time	time	NN
cord-006860-a3b8hyyr	2519	44	.	.	.
cord-006860-a3b8hyyr	2520	1	Criterion	criterion	NN
cord-006860-a3b8hyyr	2520	2	for	for	IN
cord-006860-a3b8hyyr	2520	3	allocation	allocation	NN
cord-006860-a3b8hyyr	2520	4	to	to	IN
cord-006860-a3b8hyyr	2520	5	a	a	DT
cord-006860-a3b8hyyr	2520	6	particular	particular	JJ
cord-006860-a3b8hyyr	2520	7	group	group	NN
cord-006860-a3b8hyyr	2520	8	was	be	VBD
cord-006860-a3b8hyyr	2520	9	type	type	NN
cord-006860-a3b8hyyr	2520	10	of	of	IN
cord-006860-a3b8hyyr	2520	11	intraoperative	intraoperative	JJ
cord-006860-a3b8hyyr	2520	12	transfusion	transfusion	NN
cord-006860-a3b8hyyr	2520	13	the	the	DT
cord-006860-a3b8hyyr	2520	14	patient	patient	NN
cord-006860-a3b8hyyr	2520	15	received	receive	VBD
cord-006860-a3b8hyyr	2520	16	:	:	:
cord-006860-a3b8hyyr	2520	17	infusion	infusion	NN
cord-006860-a3b8hyyr	2520	18	of	of	IN
cord-006860-a3b8hyyr	2520	19	whole	whole	JJ
cord-006860-a3b8hyyr	2520	20	blood	blood	NN
cord-006860-a3b8hyyr	2520	21	,	,	,
cord-006860-a3b8hyyr	2520	22	erythrocyte	erythrocyte	NN
cord-006860-a3b8hyyr	2520	23	concentrate	concentrate	VBP
cord-006860-a3b8hyyr	2520	24	or	or	CC
cord-006860-a3b8hyyr	2520	25	fresh	fresh	JJ
cord-006860-a3b8hyyr	2520	26	frozen	frozen	JJ
cord-006860-a3b8hyyr	2520	27	plasma	plasma	NN
cord-006860-a3b8hyyr	2520	28	.	.	.
cord-006860-a3b8hyyr	2521	1	At	at	IN
cord-006860-a3b8hyyr	2521	2	eight	eight	CD
cord-006860-a3b8hyyr	2521	3	fixed	fix	VBN
cord-006860-a3b8hyyr	2521	4	times	time	NNS
cord-006860-a3b8hyyr	2521	5	the	the	DT
cord-006860-a3b8hyyr	2521	6	activity	activity	NN
cord-006860-a3b8hyyr	2521	7	or	or	CC
cord-006860-a3b8hyyr	2521	8	concentration	concentration	NN
cord-006860-a3b8hyyr	2521	9	of	of	IN
cord-006860-a3b8hyyr	2521	10	the	the	DT
cord-006860-a3b8hyyr	2521	11	components	component	NNS
cord-006860-a3b8hyyr	2521	12	of	of	IN
cord-006860-a3b8hyyr	2521	13	the	the	DT
cord-006860-a3b8hyyr	2521	14	kallikrein	kallikrein	NNP
cord-006860-a3b8hyyr	2521	15	-	-	HYPH
cord-006860-a3b8hyyr	2521	16	kinin	kinin	NNP
cord-006860-a3b8hyyr	2521	17	and	and	CC
cord-006860-a3b8hyyr	2521	18	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	2521	19	systems	system	NNS
cord-006860-a3b8hyyr	2521	20	was	be	VBD
cord-006860-a3b8hyyr	2521	21	determined	determine	VBN
cord-006860-a3b8hyyr	2521	22	.	.	.
cord-006860-a3b8hyyr	2522	1	The	the	DT
cord-006860-a3b8hyyr	2522	2	statistic	statistic	NN
cord-006860-a3b8hyyr	2522	3	evaluation	evaluation	NN
cord-006860-a3b8hyyr	2522	4	ensued	ensue	VBD
cord-006860-a3b8hyyr	2522	5	with	with	IN
cord-006860-a3b8hyyr	2522	6	the	the	DT
cord-006860-a3b8hyyr	2522	7	SPSS	SPSS	NNP
cord-006860-a3b8hyyr	2522	8	software	software	NN
cord-006860-a3b8hyyr	2522	9	package	package	NN
cord-006860-a3b8hyyr	2522	10	.	.	.
cord-006860-a3b8hyyr	2523	1	For	for	IN
cord-006860-a3b8hyyr	2523	2	all	all	DT
cord-006860-a3b8hyyr	2523	3	three	three	CD
cord-006860-a3b8hyyr	2523	4	patient	patient	NN
cord-006860-a3b8hyyr	2523	5	collectives	collective	NNS
cord-006860-a3b8hyyr	2523	6	an	an	DT
cord-006860-a3b8hyyr	2523	7	activation	activation	NN
cord-006860-a3b8hyyr	2523	8	of	of	IN
cord-006860-a3b8hyyr	2523	9	both	both	DT
cord-006860-a3b8hyyr	2523	10	systems	system	NNS
cord-006860-a3b8hyyr	2523	11	was	be	VBD
cord-006860-a3b8hyyr	2523	12	to	to	TO
cord-006860-a3b8hyyr	2523	13	be	be	VB
cord-006860-a3b8hyyr	2523	14	observed	observe	VBN
cord-006860-a3b8hyyr	2523	15	with	with	IN
cord-006860-a3b8hyyr	2523	16	the	the	DT
cord-006860-a3b8hyyr	2523	17	TEPH	TEPH	NNP
cord-006860-a3b8hyyr	2523	18	-	-	HYPH
cord-006860-a3b8hyyr	2523	19	implantation	implantation	NN
cord-006860-a3b8hyyr	2523	20	whereby	whereby	WRB
cord-006860-a3b8hyyr	2523	21	there	there	EX
cord-006860-a3b8hyyr	2523	22	were	be	VBD
cord-006860-a3b8hyyr	2523	23	no	no	DT
cord-006860-a3b8hyyr	2523	24	statistically	statistically	RB
cord-006860-a3b8hyyr	2523	25	striking	striking	JJ
cord-006860-a3b8hyyr	2523	26	differences	difference	NNS
cord-006860-a3b8hyyr	2523	27	between	between	IN
cord-006860-a3b8hyyr	2523	28	the	the	DT
cord-006860-a3b8hyyr	2523	29	three	three	CD
cord-006860-a3b8hyyr	2523	30	groups	group	NNS
cord-006860-a3b8hyyr	2523	31	.	.	.
cord-006860-a3b8hyyr	2524	1	Thus	thus	RB
cord-006860-a3b8hyyr	2524	2	in	in	IN
cord-006860-a3b8hyyr	2524	3	the	the	DT
cord-006860-a3b8hyyr	2524	4	case	case	NN
cord-006860-a3b8hyyr	2524	5	of	of	IN
cord-006860-a3b8hyyr	2524	6	the	the	DT
cord-006860-a3b8hyyr	2524	7	kallikrein	kallikrein	JJ
cord-006860-a3b8hyyr	2524	8	-	-	HYPH
cord-006860-a3b8hyyr	2524	9	like	like	JJ
cord-006860-a3b8hyyr	2524	10	activity	activity	NN
cord-006860-a3b8hyyr	2524	11	an	an	DT
cord-006860-a3b8hyyr	2524	12	intraoperative	intraoperative	JJ
cord-006860-a3b8hyyr	2524	13	rise	rise	NN
cord-006860-a3b8hyyr	2524	14	of	of	IN
cord-006860-a3b8hyyr	2524	15	over	over	IN
cord-006860-a3b8hyyr	2524	16	37	37	CD
cord-006860-a3b8hyyr	2524	17	%	%	NN
cord-006860-a3b8hyyr	2524	18	was	be	VBD
cord-006860-a3b8hyyr	2524	19	registered	register	VBN
cord-006860-a3b8hyyr	2524	20	,	,	,
cord-006860-a3b8hyyr	2524	21	while	while	IN
cord-006860-a3b8hyyr	2524	22	at	at	IN
cord-006860-a3b8hyyr	2524	23	the	the	DT
cord-006860-a3b8hyyr	2524	24	same	same	JJ
cord-006860-a3b8hyyr	2524	25	point	point	NN
cord-006860-a3b8hyyr	2524	26	in	in	IN
cord-006860-a3b8hyyr	2524	27	time	time	NN
cord-006860-a3b8hyyr	2524	28	there	there	EX
cord-006860-a3b8hyyr	2524	29	was	be	VBD
cord-006860-a3b8hyyr	2524	30	only	only	RB
cord-006860-a3b8hyyr	2524	31	a	a	DT
cord-006860-a3b8hyyr	2524	32	4	4	CD
cord-006860-a3b8hyyr	2524	33	%	%	NN
cord-006860-a3b8hyyr	2524	34	reduction	reduction	NN
cord-006860-a3b8hyyr	2524	35	in	in	IN
cord-006860-a3b8hyyr	2524	36	the	the	DT
cord-006860-a3b8hyyr	2524	37	prekallikrein	prekallikrein	NN
cord-006860-a3b8hyyr	2524	38	activity	activity	NN
cord-006860-a3b8hyyr	2524	39	.	.	.
cord-006860-a3b8hyyr	2525	1	Postoperatively	postoperatively	RB
cord-006860-a3b8hyyr	2525	2	a	a	DT
cord-006860-a3b8hyyr	2525	3	10	10	CD
cord-006860-a3b8hyyr	2525	4	%	%	NN
cord-006860-a3b8hyyr	2525	5	rise	rise	NN
cord-006860-a3b8hyyr	2525	6	in	in	IN
cord-006860-a3b8hyyr	2525	7	the	the	DT
cord-006860-a3b8hyyr	2525	8	prekallikrein	prekallikrein	NNP
cord-006860-a3b8hyyr	2525	9	activity	activity	NN
cord-006860-a3b8hyyr	2525	10	was	be	VBD
cord-006860-a3b8hyyr	2525	11	to	to	TO
cord-006860-a3b8hyyr	2525	12	be	be	VB
cord-006860-a3b8hyyr	2525	13	observed	observe	VBN
cord-006860-a3b8hyyr	2525	14	.	.	.
cord-006860-a3b8hyyr	2526	1	As	as	IN
cord-006860-a3b8hyyr	2526	2	a	a	DT
cord-006860-a3b8hyyr	2526	3	reserve	reserve	NN
cord-006860-a3b8hyyr	2526	4	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2526	5	alpha	alpha	NN
cord-006860-a3b8hyyr	2526	6	2-macroglobalin	2-macroglobalin	CD
cord-006860-a3b8hyyr	2526	7	showed	show	VBD
cord-006860-a3b8hyyr	2526	8	no	no	DT
cord-006860-a3b8hyyr	2526	9	significant	significant	JJ
cord-006860-a3b8hyyr	2526	10	change	change	NN
cord-006860-a3b8hyyr	2526	11	in	in	IN
cord-006860-a3b8hyyr	2526	12	activity	activity	NN
cord-006860-a3b8hyyr	2526	13	during	during	IN
cord-006860-a3b8hyyr	2526	14	the	the	DT
cord-006860-a3b8hyyr	2526	15	period	period	NN
cord-006860-a3b8hyyr	2526	16	of	of	IN
cord-006860-a3b8hyyr	2526	17	observation	observation	NN
cord-006860-a3b8hyyr	2526	18	whereas	whereas	IN
cord-006860-a3b8hyyr	2526	19	the	the	DT
cord-006860-a3b8hyyr	2526	20	acute	acute	JJ
cord-006860-a3b8hyyr	2526	21	phase	phase	NN
cord-006860-a3b8hyyr	2526	22	proteins	protein	NNS
cord-006860-a3b8hyyr	2526	23	alpha	alpha	NN
cord-006860-a3b8hyyr	2526	24	1-proteinase	1-proteinase	CD
cord-006860-a3b8hyyr	2526	25	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2526	26	and	and	CC
cord-006860-a3b8hyyr	2526	27	Cl	Cl	NNP
cord-006860-a3b8hyyr	2526	28	-	-	HYPH
cord-006860-a3b8hyyr	2526	29	esterase	esterase	NN
cord-006860-a3b8hyyr	2526	30	-	-	HYPH
cord-006860-a3b8hyyr	2526	31	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2526	32	yielded	yield	VBD
cord-006860-a3b8hyyr	2526	33	a	a	DT
cord-006860-a3b8hyyr	2526	34	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	2526	35	rise	rise	NN
cord-006860-a3b8hyyr	2526	36	of	of	IN
cord-006860-a3b8hyyr	2526	37	135	135	CD
cord-006860-a3b8hyyr	2526	38	%	%	NN
cord-006860-a3b8hyyr	2526	39	and	and	CC
cord-006860-a3b8hyyr	2526	40	up	up	IN
cord-006860-a3b8hyyr	2526	41	to	to	TO
cord-006860-a3b8hyyr	2526	42	100	100	CD
cord-006860-a3b8hyyr	2526	43	%	%	NN
cord-006860-a3b8hyyr	2526	44	.	.	.
cord-006860-a3b8hyyr	2527	1	The	the	DT
cord-006860-a3b8hyyr	2527	2	beta	beta	NN
cord-006860-a3b8hyyr	2527	3	-	-	HYPH
cord-006860-a3b8hyyr	2527	4	factor	factor	NN
cord-006860-a3b8hyyr	2527	5	Xllainhibition	Xllainhibition	NNP
cord-006860-a3b8hyyr	2527	6	showed	show	VBD
cord-006860-a3b8hyyr	2527	7	a	a	DT
cord-006860-a3b8hyyr	2527	8	rise	rise	NN
cord-006860-a3b8hyyr	2527	9	of	of	IN
cord-006860-a3b8hyyr	2527	10	121	121	CD
cord-006860-a3b8hyyr	2527	11	%	%	NN
cord-006860-a3b8hyyr	2527	12	during	during	IN
cord-006860-a3b8hyyr	2527	13	the	the	DT
cord-006860-a3b8hyyr	2527	14	reconvalescent	reconvalescent	NN
cord-006860-a3b8hyyr	2527	15	phase	phase	NN
cord-006860-a3b8hyyr	2527	16	.	.	.
cord-006860-a3b8hyyr	2528	1	The	the	DT
cord-006860-a3b8hyyr	2528	2	65	65	CD
cord-006860-a3b8hyyr	2528	3	year	year	NN
cord-006860-a3b8hyyr	2528	4	old	old	JJ
cord-006860-a3b8hyyr	2528	5	female	female	JJ
cord-006860-a3b8hyyr	2528	6	caucasian	caucasian	JJ
cord-006860-a3b8hyyr	2528	7	patient	patient	NN
cord-006860-a3b8hyyr	2528	8	presented	present	VBN
cord-006860-a3b8hyyr	2528	9	here	here	RB
cord-006860-a3b8hyyr	2528	10	,	,	,
cord-006860-a3b8hyyr	2528	11	was	be	VBD
cord-006860-a3b8hyyr	2528	12	admitted	admit	VBN
cord-006860-a3b8hyyr	2528	13	to	to	IN
cord-006860-a3b8hyyr	2528	14	a	a	DT
cord-006860-a3b8hyyr	2528	15	nearby	nearby	JJ
cord-006860-a3b8hyyr	2528	16	district	district	NN
cord-006860-a3b8hyyr	2528	17	hospital	hospital	NN
cord-006860-a3b8hyyr	2528	18	in	in	IN
cord-006860-a3b8hyyr	2528	19	December	December	NNP
cord-006860-a3b8hyyr	2528	20	'	'	POS
cord-006860-a3b8hyyr	2528	21	94	94	CD
cord-006860-a3b8hyyr	2528	22	with	with	IN
cord-006860-a3b8hyyr	2528	23	the	the	DT
cord-006860-a3b8hyyr	2528	24	acute	acute	JJ
cord-006860-a3b8hyyr	2528	25	symptoms	symptom	NNS
cord-006860-a3b8hyyr	2528	26	of	of	IN
cord-006860-a3b8hyyr	2528	27	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	2528	28	embolism	embolism	NN
cord-006860-a3b8hyyr	2528	29	.	.	.
cord-006860-a3b8hyyr	2529	1	The	the	DT
cord-006860-a3b8hyyr	2529	2	source	source	NN
cord-006860-a3b8hyyr	2529	3	of	of	IN
cord-006860-a3b8hyyr	2529	4	the	the	DT
cord-006860-a3b8hyyr	2529	5	embolus	embolus	NN
cord-006860-a3b8hyyr	2529	6	could	could	MD
cord-006860-a3b8hyyr	2529	7	not	not	RB
cord-006860-a3b8hyyr	2529	8	be	be	VB
cord-006860-a3b8hyyr	2529	9	detected	detect	VBN
cord-006860-a3b8hyyr	2529	10	.	.	.
cord-006860-a3b8hyyr	2530	1	High	high	JJ
cord-006860-a3b8hyyr	2530	2	dose	dose	NN
cord-006860-a3b8hyyr	2530	3	heparin	heparin	NN
cord-006860-a3b8hyyr	2530	4	was	be	VBD
cord-006860-a3b8hyyr	2530	5	administered	administer	VBN
cord-006860-a3b8hyyr	2530	6	.	.	.
cord-006860-a3b8hyyr	2531	1	PMI	PMI	NNP
cord-006860-a3b8hyyr	2531	2	-	-	HYPH
cord-006860-a3b8hyyr	2531	3	I	I	NNP
cord-006860-a3b8hyyr	2531	4	revealed	reveal	VBD
cord-006860-a3b8hyyr	2531	5	a	a	DT
cord-006860-a3b8hyyr	2531	6	coronary	coronary	JJ
cord-006860-a3b8hyyr	2531	7	artery	artery	NN
cord-006860-a3b8hyyr	2531	8	disease	disease	NN
cord-006860-a3b8hyyr	2531	9	and	and	CC
cord-006860-a3b8hyyr	2531	10	a	a	DT
cord-006860-a3b8hyyr	2531	11	peripheral	peripheral	JJ
cord-006860-a3b8hyyr	2531	12	artery	artery	NN
cord-006860-a3b8hyyr	2531	13	occlusive	occlusive	JJ
cord-006860-a3b8hyyr	2531	14	disease	disease	NN
cord-006860-a3b8hyyr	2531	15	of	of	IN
cord-006860-a3b8hyyr	2531	16	the	the	DT
cord-006860-a3b8hyyr	2531	17	left	left	JJ
cord-006860-a3b8hyyr	2531	18	lower	low	JJR
cord-006860-a3b8hyyr	2531	19	leg	leg	NN
cord-006860-a3b8hyyr	2531	20	,	,	,
cord-006860-a3b8hyyr	2531	21	yet	yet	CC
cord-006860-a3b8hyyr	2531	22	blood	blood	NN
cord-006860-a3b8hyyr	2531	23	pressure	pressure	NN
cord-006860-a3b8hyyr	2531	24	values	value	NNS
cord-006860-a3b8hyyr	2531	25	of	of	IN
cord-006860-a3b8hyyr	2531	26	the	the	DT
cord-006860-a3b8hyyr	2531	27	lower	low	JJR
cord-006860-a3b8hyyr	2531	28	ex	ex	NN
cord-006860-a3b8hyyr	2531	29	~	~	CD
cord-006860-a3b8hyyr	2531	30	emities	emitie	NNS
cord-006860-a3b8hyyr	2531	31	were	be	VBD
cord-006860-a3b8hyyr	2531	32	only	only	RB
cord-006860-a3b8hyyr	2531	33	slightly	slightly	RB
cord-006860-a3b8hyyr	2531	34	below	below	IN
cord-006860-a3b8hyyr	2531	35	brachial	brachial	JJ
cord-006860-a3b8hyyr	2531	36	pressures	pressure	NNS
cord-006860-a3b8hyyr	2531	37	.	.	.
cord-006860-a3b8hyyr	2532	1	The	the	DT
cord-006860-a3b8hyyr	2532	2	first	first	JJ
cord-006860-a3b8hyyr	2532	3	episode	episode	NN
cord-006860-a3b8hyyr	2532	4	of	of	IN
cord-006860-a3b8hyyr	2532	5	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	2532	6	embolism	embolism	NN
cord-006860-a3b8hyyr	2532	7	was	be	VBD
cord-006860-a3b8hyyr	2532	8	followed	follow	VBN
cord-006860-a3b8hyyr	2532	9	by	by	IN
cord-006860-a3b8hyyr	2532	10	a	a	DT
cord-006860-a3b8hyyr	2532	11	second	second	JJ
cord-006860-a3b8hyyr	2532	12	one	one	CD
cord-006860-a3b8hyyr	2532	13	two	two	CD
cord-006860-a3b8hyyr	2532	14	weeks	week	NNS
cord-006860-a3b8hyyr	2532	15	later	later	RB
cord-006860-a3b8hyyr	2532	16	for	for	IN
cord-006860-a3b8hyyr	2532	17	which	which	WDT
cord-006860-a3b8hyyr	2532	18	the	the	DT
cord-006860-a3b8hyyr	2532	19	patient	patient	NN
cord-006860-a3b8hyyr	2532	20	received	receive	VBD
cord-006860-a3b8hyyr	2532	21	heparin	heparin	NN
cord-006860-a3b8hyyr	2532	22	again	again	RB
cord-006860-a3b8hyyr	2532	23	.	.	.
cord-006860-a3b8hyyr	2533	1	Following	follow	VBG
cord-006860-a3b8hyyr	2533	2	this	this	DT
cord-006860-a3b8hyyr	2533	3	treatment	treatment	NN
cord-006860-a3b8hyyr	2533	4	the	the	DT
cord-006860-a3b8hyyr	2533	5	platelet	platelet	NN
cord-006860-a3b8hyyr	2533	6	count	count	NN
cord-006860-a3b8hyyr	2533	7	decreased	decrease	VBD
cord-006860-a3b8hyyr	2533	8	significantly	significantly	RB
cord-006860-a3b8hyyr	2533	9	to	to	IN
cord-006860-a3b8hyyr	2533	10	10	10	CD
cord-006860-a3b8hyyr	2533	11	/	/	SYM
cord-006860-a3b8hyyr	2533	12	ni	ni	NN
cord-006860-a3b8hyyr	2533	13	.	.	.
cord-006860-a3b8hyyr	2534	1	With	with	IN
cord-006860-a3b8hyyr	2534	2	an	an	DT
cord-006860-a3b8hyyr	2534	3	acute	acute	JJ
cord-006860-a3b8hyyr	2534	4	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2534	5	of	of	IN
cord-006860-a3b8hyyr	2534	6	the	the	DT
cord-006860-a3b8hyyr	2534	7	lower	low	JJR
cord-006860-a3b8hyyr	2534	8	caval	caval	NN
cord-006860-a3b8hyyr	2534	9	vein	vein	NN
cord-006860-a3b8hyyr	2534	10	and	and	CC
cord-006860-a3b8hyyr	2534	11	with	with	IN
cord-006860-a3b8hyyr	2534	12	Leriche	Leriche	NNP
cord-006860-a3b8hyyr	2534	13	's	's	POS
cord-006860-a3b8hyyr	2534	14	Syndrome	Syndrome	NNP
cord-006860-a3b8hyyr	2534	15	,	,	,
cord-006860-a3b8hyyr	2534	16	i.	i.	NNP
cord-006860-a3b8hyyr	2534	17	e.	e.	NNP
cord-006860-a3b8hyyr	2534	18	occlusion	occlusion	NN
cord-006860-a3b8hyyr	2534	19	of	of	IN
cord-006860-a3b8hyyr	2534	20	the	the	DT
cord-006860-a3b8hyyr	2534	21	abdominal	abdominal	JJ
cord-006860-a3b8hyyr	2534	22	antra	antra	NNP
cord-006860-a3b8hyyr	2534	23	from	from	IN
cord-006860-a3b8hyyr	2534	24	the	the	DT
cord-006860-a3b8hyyr	2534	25	bifurcation	bifurcation	NN
cord-006860-a3b8hyyr	2534	26	down	down	RP
cord-006860-a3b8hyyr	2534	27	to	to	IN
cord-006860-a3b8hyyr	2534	28	the	the	DT
cord-006860-a3b8hyyr	2534	29	ileofemoral	ileofemoral	JJ
cord-006860-a3b8hyyr	2534	30	arteries	artery	NNS
cord-006860-a3b8hyyr	2534	31	bilaterally	bilaterally	RB
cord-006860-a3b8hyyr	2534	32	,	,	,
cord-006860-a3b8hyyr	2534	33	the	the	DT
cord-006860-a3b8hyyr	2534	34	patient	patient	NN
cord-006860-a3b8hyyr	2534	35	was	be	VBD
cord-006860-a3b8hyyr	2534	36	transferred	transfer	VBN
cord-006860-a3b8hyyr	2534	37	to	to	IN
cord-006860-a3b8hyyr	2534	38	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2534	39	hospital	hospital	NN
cord-006860-a3b8hyyr	2534	40	.	.	.
cord-006860-a3b8hyyr	2535	1	On	on	IN
cord-006860-a3b8hyyr	2535	2	initial	initial	JJ
cord-006860-a3b8hyyr	2535	3	examination	examination	NN
cord-006860-a3b8hyyr	2535	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	2535	5	saw	see	VBD
cord-006860-a3b8hyyr	2535	6	a	a	DT
cord-006860-a3b8hyyr	2535	7	patient	patient	NN
cord-006860-a3b8hyyr	2535	8	in	in	IN
cord-006860-a3b8hyyr	2535	9	no	no	DT
cord-006860-a3b8hyyr	2535	10	acute	acute	JJ
cord-006860-a3b8hyyr	2535	11	distress	distress	NN
cord-006860-a3b8hyyr	2535	12	,	,	,
cord-006860-a3b8hyyr	2535	13	no	no	DT
cord-006860-a3b8hyyr	2535	14	dyspnea	dyspnea	NN
cord-006860-a3b8hyyr	2535	15	,	,	,
cord-006860-a3b8hyyr	2535	16	blood	blood	NN
cord-006860-a3b8hyyr	2535	17	pressure	pressure	NN
cord-006860-a3b8hyyr	2535	18	120/80	120/80	CD
cord-006860-a3b8hyyr	2535	19	mmHg	mmHg	NNS
cord-006860-a3b8hyyr	2535	20	,	,	,
cord-006860-a3b8hyyr	2535	21	pulse	pulse	NN
cord-006860-a3b8hyyr	2535	22	94	94	CD
cord-006860-a3b8hyyr	2535	23	/	/	SYM
cord-006860-a3b8hyyr	2535	24	rain	rain	NN
cord-006860-a3b8hyyr	2535	25	,	,	,
cord-006860-a3b8hyyr	2535	26	no	no	DT
cord-006860-a3b8hyyr	2535	27	peripheral	peripheral	JJ
cord-006860-a3b8hyyr	2535	28	edema	edema	NN
cord-006860-a3b8hyyr	2535	29	or	or	CC
cord-006860-a3b8hyyr	2535	30	disturbances	disturbance	NNS
cord-006860-a3b8hyyr	2535	31	of	of	IN
cord-006860-a3b8hyyr	2535	32	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	2535	33	.	.	.
cord-006860-a3b8hyyr	2536	1	Neither	neither	DT
cord-006860-a3b8hyyr	2536	2	femoral	femoral	JJ
cord-006860-a3b8hyyr	2536	3	,	,	,
cord-006860-a3b8hyyr	2536	4	popliteal	popliteal	JJ
cord-006860-a3b8hyyr	2536	5	,	,	,
cord-006860-a3b8hyyr	2536	6	nor	nor	CC
cord-006860-a3b8hyyr	2536	7	pedic	pedic	NN
cord-006860-a3b8hyyr	2536	8	pulses	pulse	NNS
cord-006860-a3b8hyyr	2536	9	were	be	VBD
cord-006860-a3b8hyyr	2536	10	palpable	palpable	JJ
cord-006860-a3b8hyyr	2536	11	on	on	IN
cord-006860-a3b8hyyr	2536	12	either	either	DT
cord-006860-a3b8hyyr	2536	13	side	side	NN
cord-006860-a3b8hyyr	2536	14	.	.	.
cord-006860-a3b8hyyr	2537	1	A	a	DT
cord-006860-a3b8hyyr	2537	2	heparin	heparin	NN
cord-006860-a3b8hyyr	2537	3	associated	associate	VBN
cord-006860-a3b8hyyr	2537	4	thrombopenia	thrombopenia	NNP
cord-006860-a3b8hyyr	2537	5	was	be	VBD
cord-006860-a3b8hyyr	2537	6	detected	detect	VBN
cord-006860-a3b8hyyr	2537	7	with	with	IN
cord-006860-a3b8hyyr	2537	8	the	the	DT
cord-006860-a3b8hyyr	2537	9	platelet	platelet	NN
cord-006860-a3b8hyyr	2537	10	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2537	11	assay	assay	NN
cord-006860-a3b8hyyr	2537	12	and	and	CC
cord-006860-a3b8hyyr	2537	13	confirmed	confirm	VBN
cord-006860-a3b8hyyr	2537	14	by	by	IN
cord-006860-a3b8hyyr	2537	15	the	the	DT
cord-006860-a3b8hyyr	2537	16	heparin	heparin	NN
cord-006860-a3b8hyyr	2537	17	induced	induce	VBN
cord-006860-a3b8hyyr	2537	18	platelet	platelet	NN
cord-006860-a3b8hyyr	2537	19	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2537	20	assay	assay	NN
cord-006860-a3b8hyyr	2537	21	(	(	-LRB-
cord-006860-a3b8hyyr	2537	22	HIPAA	HIPAA	NNP
cord-006860-a3b8hyyr	2537	23	)	)	-RRB-
cord-006860-a3b8hyyr	2537	24	.	.	.
cord-006860-a3b8hyyr	2538	1	The	the	DT
cord-006860-a3b8hyyr	2538	2	autoantibodies	autoantibody	NNS
cord-006860-a3b8hyyr	2538	3	targeting	target	VBG
cord-006860-a3b8hyyr	2538	4	the	the	DT
cord-006860-a3b8hyyr	2538	5	underlying	underlie	VBG
cord-006860-a3b8hyyr	2538	6	PF4-heparin	pf4-heparin	NN
cord-006860-a3b8hyyr	2538	7	complex	complex	NN
cord-006860-a3b8hyyr	2538	8	were	be	VBD
cord-006860-a3b8hyyr	2538	9	determined	determine	VBN
cord-006860-a3b8hyyr	2538	10	later	later	RB
cord-006860-a3b8hyyr	2538	11	by	by	IN
cord-006860-a3b8hyyr	2538	12	an	an	DT
cord-006860-a3b8hyyr	2538	13	Elisa	Elisa	NNP
cord-006860-a3b8hyyr	2538	14	method	method	NN
cord-006860-a3b8hyyr	2538	15	in	in	IN
cord-006860-a3b8hyyr	2538	16	serum	serum	NN
cord-006860-a3b8hyyr	2538	17	samples	sample	NNS
cord-006860-a3b8hyyr	2538	18	of	of	IN
cord-006860-a3b8hyyr	2538	19	the	the	DT
cord-006860-a3b8hyyr	2538	20	patient	patient	NN
cord-006860-a3b8hyyr	2539	1	(	(	-LRB-
cord-006860-a3b8hyyr	2539	2	Asserachrom	Asserachrom	NNP
cord-006860-a3b8hyyr	2539	3	HIA	HIA	NNP
cord-006860-a3b8hyyr	2539	4	,	,	,
cord-006860-a3b8hyyr	2539	5	Diagnostica	Diagnostica	NNP
cord-006860-a3b8hyyr	2539	6	St	St	NNP
cord-006860-a3b8hyyr	2539	7	,	,	,
cord-006860-a3b8hyyr	2539	8	ago	ago	RB
cord-006860-a3b8hyyr	2539	9	)	)	-RRB-
cord-006860-a3b8hyyr	2539	10	.	.	.
cord-006860-a3b8hyyr	2540	1	A	a	DT
cord-006860-a3b8hyyr	2540	2	temporary	temporary	JJ
cord-006860-a3b8hyyr	2540	3	Anth&~r	Anth&~r	NNP
cord-006860-a3b8hyyr	2540	4	filter	filter	NN
cord-006860-a3b8hyyr	2540	5	system	system	NN
cord-006860-a3b8hyyr	2540	6	was	be	VBD
cord-006860-a3b8hyyr	2540	7	inserted	insert	VBN
cord-006860-a3b8hyyr	2540	8	transbmchially	transbmchially	RB
cord-006860-a3b8hyyr	2540	9	into	into	IN
cord-006860-a3b8hyyr	2540	10	the	the	DT
cord-006860-a3b8hyyr	2540	11	lower	low	JJR
cord-006860-a3b8hyyr	2540	12	eaval	eaval	JJ
cord-006860-a3b8hyyr	2540	13	vein	vein	NN
cord-006860-a3b8hyyr	2540	14	and	and	CC
cord-006860-a3b8hyyr	2540	15	placed	place	VBN
cord-006860-a3b8hyyr	2540	16	jnst	jnst	NN
cord-006860-a3b8hyyr	2540	17	above	above	IN
cord-006860-a3b8hyyr	2540	18	the	the	DT
cord-006860-a3b8hyyr	2540	19	thrombus	thrombus	NN
cord-006860-a3b8hyyr	2540	20	.	.	.
cord-006860-a3b8hyyr	2541	1	In	in	IN
cord-006860-a3b8hyyr	2541	2	the	the	DT
cord-006860-a3b8hyyr	2541	3	following	follow	VBG
cord-006860-a3b8hyyr	2541	4	days	day	NNS
cord-006860-a3b8hyyr	2541	5	,	,	,
cord-006860-a3b8hyyr	2541	6	2	2	CD
cord-006860-a3b8hyyr	2541	7	cycles	cycle	NNS
cord-006860-a3b8hyyr	2541	8	of	of	IN
cord-006860-a3b8hyyr	2541	9	lysis	lysis	NN
cord-006860-a3b8hyyr	2541	10	therapy	therapy	NN
cord-006860-a3b8hyyr	2541	11	with	with	IN
cord-006860-a3b8hyyr	2541	12	9	9	CD
cord-006860-a3b8hyyr	2541	13	Mil	Mil	NNP
cord-006860-a3b8hyyr	2541	14	U	U	NNP
cord-006860-a3b8hyyr	2541	15	streptokinase	streptokinase	NNP
cord-006860-a3b8hyyr	2541	16	were	be	VBD
cord-006860-a3b8hyyr	2541	17	administered	administer	VBN
cord-006860-a3b8hyyr	2541	18	taking	take	VBG
cord-006860-a3b8hyyr	2541	19	six	six	CD
cord-006860-a3b8hyyr	2541	20	hours	hour	NNS
cord-006860-a3b8hyyr	2541	21	for	for	IN
cord-006860-a3b8hyyr	2541	22	each	each	DT
cord-006860-a3b8hyyr	2541	23	cycle	cycle	NN
cord-006860-a3b8hyyr	2541	24	.	.	.
cord-006860-a3b8hyyr	2542	1	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	2542	2	was	be	VBD
cord-006860-a3b8hyyr	2542	3	given	give	VBN
cord-006860-a3b8hyyr	2542	4	in	in	IN
cord-006860-a3b8hyyr	2542	5	the	the	DT
cord-006860-a3b8hyyr	2542	6	mean	mean	JJ
cord-006860-a3b8hyyr	2542	7	time	time	NN
cord-006860-a3b8hyyr	2542	8	via	via	IN
cord-006860-a3b8hyyr	2542	9	the	the	DT
cord-006860-a3b8hyyr	2542	10	filter	filter	NN
cord-006860-a3b8hyyr	2542	11	system	system	NN
cord-006860-a3b8hyyr	2542	12	in	in	IN
cord-006860-a3b8hyyr	2542	13	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	2542	14	dosages	dosage	NNS
cord-006860-a3b8hyyr	2542	15	in	in	IN
cord-006860-a3b8hyyr	2542	16	order	order	NN
cord-006860-a3b8hyyr	2542	17	to	to	TO
cord-006860-a3b8hyyr	2542	18	prolong	prolong	VB
cord-006860-a3b8hyyr	2542	19	values	value	NNS
cord-006860-a3b8hyyr	2542	20	1.5	1.5	CD
cord-006860-a3b8hyyr	2542	21	to	to	TO
cord-006860-a3b8hyyr	2542	22	2	2	CD
cord-006860-a3b8hyyr	2542	23	times	time	NNS
cord-006860-a3b8hyyr	2542	24	the	the	DT
cord-006860-a3b8hyyr	2542	25	individual	individual	JJ
cord-006860-a3b8hyyr	2542	26	base	base	NN
cord-006860-a3b8hyyr	2542	27	line	line	NN
cord-006860-a3b8hyyr	2542	28	level	level	NN
cord-006860-a3b8hyyr	2542	29	.	.	.
cord-006860-a3b8hyyr	2543	1	At	at	IN
cord-006860-a3b8hyyr	2543	2	the	the	DT
cord-006860-a3b8hyyr	2543	3	end	end	NN
cord-006860-a3b8hyyr	2543	4	of	of	IN
cord-006860-a3b8hyyr	2543	5	the	the	DT
cord-006860-a3b8hyyr	2543	6	second	second	JJ
cord-006860-a3b8hyyr	2543	7	cycle	cycle	NN
cord-006860-a3b8hyyr	2543	8	,	,	,
cord-006860-a3b8hyyr	2543	9	pulses	pulse	NNS
cord-006860-a3b8hyyr	2543	10	were	be	VBD
cord-006860-a3b8hyyr	2543	11	palpable	palpable	JJ
cord-006860-a3b8hyyr	2543	12	inguinally	inguinally	RB
cord-006860-a3b8hyyr	2543	13	,	,	,
cord-006860-a3b8hyyr	2543	14	two	two	CD
cord-006860-a3b8hyyr	2543	15	hours	hour	NNS
cord-006860-a3b8hyyr	2543	16	later	later	RB
cord-006860-a3b8hyyr	2543	17	both	both	CC
cord-006860-a3b8hyyr	2543	18	popliteal	popliteal	JJ
cord-006860-a3b8hyyr	2543	19	and	and	CC
cord-006860-a3b8hyyr	2543	20	the	the	DT
cord-006860-a3b8hyyr	2543	21	right	right	JJ
cord-006860-a3b8hyyr	2543	22	pedic	pedic	NN
cord-006860-a3b8hyyr	2543	23	pulse	pulse	NN
cord-006860-a3b8hyyr	2543	24	were	be	VBD
cord-006860-a3b8hyyr	2543	25	present	present	JJ
cord-006860-a3b8hyyr	2543	26	.	.	.
cord-006860-a3b8hyyr	2544	1	The	the	DT
cord-006860-a3b8hyyr	2544	2	left	left	JJ
cord-006860-a3b8hyyr	2544	3	leg	leg	NN
cord-006860-a3b8hyyr	2544	4	showed	show	VBD
cord-006860-a3b8hyyr	2544	5	better	well	JJR
cord-006860-a3b8hyyr	2544	6	microperfusion	microperfusion	NN
cord-006860-a3b8hyyr	2544	7	than	than	IN
cord-006860-a3b8hyyr	2544	8	before	before	RB
cord-006860-a3b8hyyr	2544	9	.	.	.
cord-006860-a3b8hyyr	2545	1	Computer	computer	NN
cord-006860-a3b8hyyr	2545	2	tumoglaphy	tumoglaphy	NN
cord-006860-a3b8hyyr	2545	3	did	do	VBD
cord-006860-a3b8hyyr	2545	4	not	not	RB
cord-006860-a3b8hyyr	2545	5	reveal	reveal	VB
cord-006860-a3b8hyyr	2545	6	an)-thrombotic	an)-thrombotic	JJ
cord-006860-a3b8hyyr	2545	7	material	material	NN
cord-006860-a3b8hyyr	2545	8	in	in	IN
cord-006860-a3b8hyyr	2545	9	the	the	DT
cord-006860-a3b8hyyr	2545	10	descending	descend	VBG
cord-006860-a3b8hyyr	2545	11	aorta	aorta	NN
cord-006860-a3b8hyyr	2545	12	and	and	CC
cord-006860-a3b8hyyr	2545	13	the	the	DT
cord-006860-a3b8hyyr	2545	14	iliac	iliac	JJ
cord-006860-a3b8hyyr	2545	15	arteries	artery	NNS
cord-006860-a3b8hyyr	2545	16	.	.	.
cord-006860-a3b8hyyr	2546	1	For	for	IN
cord-006860-a3b8hyyr	2546	2	continuous	continuous	JJ
cord-006860-a3b8hyyr	2546	3	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	2546	4	after	after	IN
cord-006860-a3b8hyyr	2546	5	lysis	lysis	NN
cord-006860-a3b8hyyr	2546	6	we	-PRON-	PRP
cord-006860-a3b8hyyr	2546	7	used	use	VBD
cord-006860-a3b8hyyr	2546	8	the	the	DT
cord-006860-a3b8hyyr	2546	9	heparinoid	heparinoid	JJ
cord-006860-a3b8hyyr	2546	10	Orgaran	Orgaran	NNP
cord-006860-a3b8hyyr	2547	1	®	®	VB
cord-006860-a3b8hyyr	2547	2	to	to	TO
cord-006860-a3b8hyyr	2547	3	overlap	overlap	VB
cord-006860-a3b8hyyr	2547	4	the	the	DT
cord-006860-a3b8hyyr	2547	5	period	period	NN
cord-006860-a3b8hyyr	2547	6	until	until	IN
cord-006860-a3b8hyyr	2547	7	full	full	JJ
cord-006860-a3b8hyyr	2547	8	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	2547	9	was	be	VBD
cord-006860-a3b8hyyr	2547	10	achieved	achieve	VBN
cord-006860-a3b8hyyr	2547	11	by	by	IN
cord-006860-a3b8hyyr	2547	12	coumarin	coumarin	NN
cord-006860-a3b8hyyr	2547	13	.	.	.
cord-006860-a3b8hyyr	2548	1	The	the	DT
cord-006860-a3b8hyyr	2548	2	heparinoid	heparinoid	NN
cord-006860-a3b8hyyr	2548	3	was	be	VBD
cord-006860-a3b8hyyr	2548	4	tested	test	VBN
cord-006860-a3b8hyyr	2548	5	before	before	IN
cord-006860-a3b8hyyr	2548	6	us	-PRON-	PRP
cord-006860-a3b8hyyr	2548	7	non	non	JJ
cord-006860-a3b8hyyr	2548	8	-	-	JJ
cord-006860-a3b8hyyr	2548	9	reactlve	reactlve	JJ
cord-006860-a3b8hyyr	2548	10	in	in	IN
cord-006860-a3b8hyyr	2548	11	the	the	DT
cord-006860-a3b8hyyr	2548	12	HIPAA	HIPAA	NNP
cord-006860-a3b8hyyr	2548	13	.	.	.
cord-006860-a3b8hyyr	2549	1	With	with	IN
cord-006860-a3b8hyyr	2549	2	this	this	DT
cord-006860-a3b8hyyr	2549	3	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2549	4	the	the	DT
cord-006860-a3b8hyyr	2549	5	platelet	platelet	NN
cord-006860-a3b8hyyr	2549	6	count	count	NN
cord-006860-a3b8hyyr	2549	7	increased	increase	VBD
cord-006860-a3b8hyyr	2549	8	to	to	IN
cord-006860-a3b8hyyr	2549	9	normal	normal	JJ
cord-006860-a3b8hyyr	2549	10	values	value	NNS
cord-006860-a3b8hyyr	2549	11	.	.	.
cord-006860-a3b8hyyr	2550	1	HAT	HAT	NNP
cord-006860-a3b8hyyr	2550	2	II	ii	CD
cord-006860-a3b8hyyr	2550	3	related	related	JJ
cord-006860-a3b8hyyr	2550	4	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2550	5	is	be	VBZ
cord-006860-a3b8hyyr	2550	6	the	the	DT
cord-006860-a3b8hyyr	2550	7	most	most	RBS
cord-006860-a3b8hyyr	2550	8	severe	severe	JJ
cord-006860-a3b8hyyr	2550	9	complication	complication	NN
cord-006860-a3b8hyyr	2550	10	of	of	IN
cord-006860-a3b8hyyr	2550	11	heparin	heparin	NN
cord-006860-a3b8hyyr	2550	12	therapy	therapy	NN
cord-006860-a3b8hyyr	2550	13	,	,	,
cord-006860-a3b8hyyr	2550	14	especially	especially	RB
cord-006860-a3b8hyyr	2550	15	in	in	IN
cord-006860-a3b8hyyr	2550	16	patients	patient	NNS
cord-006860-a3b8hyyr	2550	17	with	with	IN
cord-006860-a3b8hyyr	2550	18	pre	pre	JJ
cord-006860-a3b8hyyr	2550	19	-	-	JJ
cord-006860-a3b8hyyr	2550	20	existing	existing	JJ
cord-006860-a3b8hyyr	2550	21	thromoembolic	thromoembolic	JJ
cord-006860-a3b8hyyr	2550	22	disorders	disorder	NNS
cord-006860-a3b8hyyr	2550	23	(	(	-LRB-
cord-006860-a3b8hyyr	2550	24	DVT	DVT	NNP
cord-006860-a3b8hyyr	2550	25	,	,	,
cord-006860-a3b8hyyr	2550	26	DIC	DIC	NNP
cord-006860-a3b8hyyr	2550	27	)	)	-RRB-
cord-006860-a3b8hyyr	2550	28	.	.	.
cord-006860-a3b8hyyr	2551	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2551	2	present	present	VBP
cord-006860-a3b8hyyr	2551	3	to	to	IN
cord-006860-a3b8hyyr	2551	4	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2551	5	knowledge	knowledge	NN
cord-006860-a3b8hyyr	2551	6	the	the	DT
cord-006860-a3b8hyyr	2551	7	first	first	JJ
cord-006860-a3b8hyyr	2551	8	case	case	NN
cord-006860-a3b8hyyr	2551	9	of	of	IN
cord-006860-a3b8hyyr	2551	10	HAT	HAT	NNP
cord-006860-a3b8hyyr	2551	11	II	II	NNP
cord-006860-a3b8hyyr	2551	12	during	during	IN
cord-006860-a3b8hyyr	2551	13	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	2551	14	therapy	therapy	NN
cord-006860-a3b8hyyr	2551	15	(	(	-LRB-
cord-006860-a3b8hyyr	2551	16	IT	it	NN
cord-006860-a3b8hyyr	2551	17	)	)	-RRB-
cord-006860-a3b8hyyr	2551	18	with	with	IN
cord-006860-a3b8hyyr	2551	19	simultaneous	simultaneous	JJ
cord-006860-a3b8hyyr	2551	20	hepatin	hepatin	NNP
cord-006860-a3b8hyyr	2551	21	administration	administration	NN
cord-006860-a3b8hyyr	2551	22	.	.	.
cord-006860-a3b8hyyr	2552	1	At	at	IN
cord-006860-a3b8hyyr	2552	2	admission	admission	NN
cord-006860-a3b8hyyr	2552	3	a	a	DT
cord-006860-a3b8hyyr	2552	4	16	16	CD
cord-006860-a3b8hyyr	2552	5	year	year	NN
cord-006860-a3b8hyyr	2552	6	old	old	JJ
cord-006860-a3b8hyyr	2552	7	girl	girl	NN
cord-006860-a3b8hyyr	2552	8	showed	show	VBD
cord-006860-a3b8hyyr	2552	9	complete	complete	JJ
cord-006860-a3b8hyyr	2552	10	occlusion	occlusion	NN
cord-006860-a3b8hyyr	2552	11	of	of	IN
cord-006860-a3b8hyyr	2552	12	the	the	DT
cord-006860-a3b8hyyr	2552	13	pelvic	pelvic	JJ
cord-006860-a3b8hyyr	2552	14	veins	vein	NNS
cord-006860-a3b8hyyr	2552	15	of	of	IN
cord-006860-a3b8hyyr	2552	16	the	the	DT
cord-006860-a3b8hyyr	2552	17	right	right	JJ
cord-006860-a3b8hyyr	2552	18	leg	leg	NN
cord-006860-a3b8hyyr	2552	19	(	(	-LRB-
cord-006860-a3b8hyyr	2552	20	R	r	NN
cord-006860-a3b8hyyr	2552	21	common	common	JJ
cord-006860-a3b8hyyr	2552	22	and	and	CC
cord-006860-a3b8hyyr	2552	23	external	external	JJ
cord-006860-a3b8hyyr	2552	24	iliac	iliac	NNP
cord-006860-a3b8hyyr	2552	25	v.	v.	IN
cord-006860-a3b8hyyr	2552	26	,	,	,
cord-006860-a3b8hyyr	2552	27	common	common	JJ
cord-006860-a3b8hyyr	2552	28	and	and	CC
cord-006860-a3b8hyyr	2552	29	proximal	proximal	JJ
cord-006860-a3b8hyyr	2552	30	superficial	superficial	JJ
cord-006860-a3b8hyyr	2552	31	femoral	femoral	NN
cord-006860-a3b8hyyr	2552	32	v.	v.	NN
cord-006860-a3b8hyyr	2552	33	)	)	-RRB-
cord-006860-a3b8hyyr	2552	34	.	.	.
cord-006860-a3b8hyyr	2553	1	As	as	IN
cord-006860-a3b8hyyr	2553	2	in	in	IN
cord-006860-a3b8hyyr	2553	3	children	child	NNS
cord-006860-a3b8hyyr	2553	4	no	no	DT
cord-006860-a3b8hyyr	2553	5	prospective	prospective	JJ
cord-006860-a3b8hyyr	2553	6	studies	study	NNS
cord-006860-a3b8hyyr	2553	7	on	on	IN
cord-006860-a3b8hyyr	2553	8	the	the	DT
cord-006860-a3b8hyyr	2553	9	thrornbolysis	thrornbolysis	NN
cord-006860-a3b8hyyr	2553	10	of	of	IN
cord-006860-a3b8hyyr	2553	11	DVT	DVT	NNP
cord-006860-a3b8hyyr	2553	12	with	with	IN
cord-006860-a3b8hyyr	2553	13	rt	rt	NNP
cord-006860-a3b8hyyr	2553	14	-	-	HYPH
cord-006860-a3b8hyyr	2553	15	PA	PA	NNP
cord-006860-a3b8hyyr	2553	16	are	be	VBP
cord-006860-a3b8hyyr	2553	17	available	available	JJ
cord-006860-a3b8hyyr	2553	18	,	,	,
cord-006860-a3b8hyyr	2553	19	we	-PRON-	PRP
cord-006860-a3b8hyyr	2553	20	started	start	VBD
cord-006860-a3b8hyyr	2553	21	TT	TT	NNP
cord-006860-a3b8hyyr	2553	22	according	accord	VBG
cord-006860-a3b8hyyr	2553	23	to	to	IN
cord-006860-a3b8hyyr	2553	24	the	the	DT
cord-006860-a3b8hyyr	2553	25	Frankfurt	Frankfurt	NNP
cord-006860-a3b8hyyr	2553	26	/	/	SYM
cord-006860-a3b8hyyr	2553	27	M.	M.	NNP
cord-006860-a3b8hyyr	2553	28	regimen	regimen	NN
cord-006860-a3b8hyyr	2553	29	:	:	:
cord-006860-a3b8hyyr	2553	30	rt	rt	NNP
cord-006860-a3b8hyyr	2553	31	-	-	HYPH
cord-006860-a3b8hyyr	2553	32	PA	PA	NNP
cord-006860-a3b8hyyr	2553	33	(	(	-LRB-
cord-006860-a3b8hyyr	2553	34	Actilyse	Actilyse	NNP
cord-006860-a3b8hyyr	2553	35	)	)	-RRB-
cord-006860-a3b8hyyr	2553	36	bolus	bolus	NN
cord-006860-a3b8hyyr	2553	37	injection	injection	NN
cord-006860-a3b8hyyr	2553	38	0.4	0.4	CD
cord-006860-a3b8hyyr	2553	39	nag	nag	NN
cord-006860-a3b8hyyr	2553	40	/	/	SYM
cord-006860-a3b8hyyr	2553	41	kg	kg	NN
cord-006860-a3b8hyyr	2554	1	bw	bw	NNP
cord-006860-a3b8hyyr	2554	2	followed	follow	VBD
cord-006860-a3b8hyyr	2554	3	by	by	IN
cord-006860-a3b8hyyr	2554	4	continuous	continuous	JJ
cord-006860-a3b8hyyr	2554	5	infusion	infusion	NN
cord-006860-a3b8hyyr	2554	6	of	of	IN
cord-006860-a3b8hyyr	2554	7	1	1	CD
cord-006860-a3b8hyyr	2554	8	mg	mg	NNP
cord-006860-a3b8hyyr	2554	9	/	/	SYM
cord-006860-a3b8hyyr	2554	10	kg	kg	NNP
cord-006860-a3b8hyyr	2554	11	bw	bw	NNP
cord-006860-a3b8hyyr	2554	12	/	/	SYM
cord-006860-a3b8hyyr	2554	13	d	d	NNP
cord-006860-a3b8hyyr	2554	14	;	;	:
cord-006860-a3b8hyyr	2554	15	simultaneous	simultaneous	JJ
cord-006860-a3b8hyyr	2554	16	low	low	JJ
cord-006860-a3b8hyyr	2554	17	dose	dose	NN
cord-006860-a3b8hyyr	2554	18	heparin	heparin	NN
cord-006860-a3b8hyyr	2554	19	100	100	CD
cord-006860-a3b8hyyr	2555	1	-200	-200	NNP
cord-006860-a3b8hyyr	2556	1	U	U	NNP
cord-006860-a3b8hyyr	2556	2	/	/	SYM
cord-006860-a3b8hyyr	2556	3	kg	kg	NNP
cord-006860-a3b8hyyr	2556	4	bw	bw	NNP
cord-006860-a3b8hyyr	2556	5	/	/	SYM
cord-006860-a3b8hyyr	2556	6	d	d	NNP
cord-006860-a3b8hyyr	2556	7	.	.	.
cord-006860-a3b8hyyr	2557	1	Doppler	Doppler	NNP
cord-006860-a3b8hyyr	2557	2	ultrasonographie	ultrasonographie	NNP
cord-006860-a3b8hyyr	2557	3	control	control	NN
cord-006860-a3b8hyyr	2557	4	on	on	IN
cord-006860-a3b8hyyr	2557	5	day	day	NN
cord-006860-a3b8hyyr	2557	6	nine	nine	CD
cord-006860-a3b8hyyr	2557	7	after	after	IN
cord-006860-a3b8hyyr	2557	8	the	the	DT
cord-006860-a3b8hyyr	2557	9	beginning	beginning	NN
cord-006860-a3b8hyyr	2557	10	of	of	IN
cord-006860-a3b8hyyr	2557	11	Tr	Tr	NNP
cord-006860-a3b8hyyr	2557	12	revealed	reveal	VBD
cord-006860-a3b8hyyr	2557	13	a	a	DT
cord-006860-a3b8hyyr	2557	14	further	further	JJ
cord-006860-a3b8hyyr	2557	15	distal	distal	JJ
cord-006860-a3b8hyyr	2557	16	growth	growth	NN
cord-006860-a3b8hyyr	2557	17	of	of	IN
cord-006860-a3b8hyyr	2557	18	the	the	DT
cord-006860-a3b8hyyr	2557	19	thrombus	thrombus	NN
cord-006860-a3b8hyyr	2557	20	into	into	IN
cord-006860-a3b8hyyr	2557	21	the	the	DT
cord-006860-a3b8hyyr	2557	22	popliteal	popliteal	JJ
cord-006860-a3b8hyyr	2557	23	vein	vein	NN
cord-006860-a3b8hyyr	2557	24	.	.	.
cord-006860-a3b8hyyr	2558	1	At	at	IN
cord-006860-a3b8hyyr	2558	2	the	the	DT
cord-006860-a3b8hyyr	2558	3	same	same	JJ
cord-006860-a3b8hyyr	2558	4	time	time	NN
cord-006860-a3b8hyyr	2558	5	AT	at	IN
cord-006860-a3b8hyyr	2558	6	IR	IR	NNP
cord-006860-a3b8hyyr	2558	7	was	be	VBD
cord-006860-a3b8hyyr	2558	8	decreased	decrease	VBN
cord-006860-a3b8hyyr	2558	9	to	to	IN
cord-006860-a3b8hyyr	2558	10	70	70	CD
cord-006860-a3b8hyyr	2558	11	%	%	NN
cord-006860-a3b8hyyr	2558	12	and	and	CC
cord-006860-a3b8hyyr	2558	13	there	there	EX
cord-006860-a3b8hyyr	2558	14	was	be	VBD
cord-006860-a3b8hyyr	2558	15	a	a	DT
cord-006860-a3b8hyyr	2558	16	dramatic	dramatic	JJ
cord-006860-a3b8hyyr	2558	17	drop	drop	NN
cord-006860-a3b8hyyr	2558	18	in	in	IN
cord-006860-a3b8hyyr	2558	19	platelet	platelet	NN
cord-006860-a3b8hyyr	2558	20	count	count	NN
cord-006860-a3b8hyyr	2558	21	to	to	IN
cord-006860-a3b8hyyr	2558	22	<	<	XX
cord-006860-a3b8hyyr	2558	23	50	50	CD
cord-006860-a3b8hyyr	2558	24	%	%	NN
cord-006860-a3b8hyyr	2558	25	of	of	IN
cord-006860-a3b8hyyr	2558	26	the	the	DT
cord-006860-a3b8hyyr	2558	27	baseline	baseline	JJ
cord-006860-a3b8hyyr	2558	28	value	value	NN
cord-006860-a3b8hyyr	2558	29	(	(	-LRB-
cord-006860-a3b8hyyr	2558	30	216	216	CD
cord-006860-a3b8hyyr	2558	31	to	to	TO
cord-006860-a3b8hyyr	2558	32	86	86	CD
cord-006860-a3b8hyyr	2558	33	Gpt/1	Gpt/1	NNP
cord-006860-a3b8hyyr	2558	34	)	)	-RRB-
cord-006860-a3b8hyyr	2558	35	.	.	.
cord-006860-a3b8hyyr	2559	1	The	the	DT
cord-006860-a3b8hyyr	2559	2	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	2559	3	HAT	hat	NN
cord-006860-a3b8hyyr	2559	4	]	]	-RRB-
cord-006860-a3b8hyyr	2560	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	2560	2	was	be	VBD
cord-006860-a3b8hyyr	2560	3	confirmed	confirm	VBN
cord-006860-a3b8hyyr	2560	4	by	by	IN
cord-006860-a3b8hyyr	2560	5	positive	positive	JJ
cord-006860-a3b8hyyr	2560	6	HIPA	HIPA	NNP
cord-006860-a3b8hyyr	2560	7	-	-	HYPH
cord-006860-a3b8hyyr	2560	8	test	test	NN
cord-006860-a3b8hyyr	2560	9	.	.	.
cord-006860-a3b8hyyr	2561	1	The	the	DT
cord-006860-a3b8hyyr	2561	2	only	only	JJ
cord-006860-a3b8hyyr	2561	3	heparin	heparin	NN
cord-006860-a3b8hyyr	2561	4	preparation	preparation	NN
cord-006860-a3b8hyyr	2561	5	not	not	RB
cord-006860-a3b8hyyr	2561	6	cross	cross	NN
cord-006860-a3b8hyyr	2561	7	-	-	NN
cord-006860-a3b8hyyr	2561	8	reacting	react	VBG
cord-006860-a3b8hyyr	2561	9	with	with	IN
cord-006860-a3b8hyyr	2561	10	the	the	DT
cord-006860-a3b8hyyr	2561	11	antibody	antibody	NN
cord-006860-a3b8hyyr	2561	12	was	be	VBD
cord-006860-a3b8hyyr	2561	13	the	the	DT
cord-006860-a3b8hyyr	2561	14	LMW	lmw	NN
cord-006860-a3b8hyyr	2561	15	heparinoid	heparinoid	NNP
cord-006860-a3b8hyyr	2561	16	Orgaran	Orgaran	NNP
cord-006860-a3b8hyyr	2561	17	.	.	.
cord-006860-a3b8hyyr	2562	1	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	2562	2	therefore	therefore	RB
cord-006860-a3b8hyyr	2562	3	was	be	VBD
cord-006860-a3b8hyyr	2562	4	replaced	replace	VBN
cord-006860-a3b8hyyr	2562	5	by	by	IN
cord-006860-a3b8hyyr	2562	6	Orgaran	orgaran	NN
cord-006860-a3b8hyyr	2562	7	:	:	:
cord-006860-a3b8hyyr	2562	8	bolus	bolus	NN
cord-006860-a3b8hyyr	2562	9	injection	injection	NN
cord-006860-a3b8hyyr	2562	10	1,500	1,500	CD
cord-006860-a3b8hyyr	2562	11	U	U	NNP
cord-006860-a3b8hyyr	2562	12	/	/	SYM
cord-006860-a3b8hyyr	2562	13	h	h	NNP
cord-006860-a3b8hyyr	2562	14	followed	follow	VBN
cord-006860-a3b8hyyr	2562	15	by	by	IN
cord-006860-a3b8hyyr	2562	16	infusion	infusion	NN
cord-006860-a3b8hyyr	2562	17	of	of	IN
cord-006860-a3b8hyyr	2562	18	200	200	CD
cord-006860-a3b8hyyr	2562	19	U	U	NNP
cord-006860-a3b8hyyr	2562	20	/	/	SYM
cord-006860-a3b8hyyr	2562	21	h	h	NN
cord-006860-a3b8hyyr	2562	22	.	.	.
cord-006860-a3b8hyyr	2563	1	rt	rt	NNP
cord-006860-a3b8hyyr	2563	2	-	-	HYPH
cord-006860-a3b8hyyr	2563	3	PA	PA	NNP
cord-006860-a3b8hyyr	2563	4	-	-	HYPH
cord-006860-a3b8hyyr	2563	5	therapy	therapy	NN
cord-006860-a3b8hyyr	2563	6	was	be	VBD
cord-006860-a3b8hyyr	2563	7	not	not	RB
cord-006860-a3b8hyyr	2563	8	discontinued	discontinue	VBN
cord-006860-a3b8hyyr	2563	9	.	.	.
cord-006860-a3b8hyyr	2564	1	AT	at	IN
cord-006860-a3b8hyyr	2564	2	RI	RI	NNP
cord-006860-a3b8hyyr	2564	3	substitution	substitution	NN
cord-006860-a3b8hyyr	2564	4	was	be	VBD
cord-006860-a3b8hyyr	2564	5	performed	perform	VBN
cord-006860-a3b8hyyr	2564	6	at	at	IN
cord-006860-a3b8hyyr	2564	7	levels	level	NNS
cord-006860-a3b8hyyr	2564	8	<	<	XX
cord-006860-a3b8hyyr	2564	9	70	70	CD
cord-006860-a3b8hyyr	2564	10	%	%	NN
cord-006860-a3b8hyyr	2564	11	.	.	.
cord-006860-a3b8hyyr	2565	1	Under	under	IN
cord-006860-a3b8hyyr	2565	2	Orgaran	Orgaran	NNP
cord-006860-a3b8hyyr	2565	3	administration	administration	NN
cord-006860-a3b8hyyr	2565	4	platelet	platelet	NN
cord-006860-a3b8hyyr	2565	5	count	count	NN
cord-006860-a3b8hyyr	2565	6	rose	rise	VBD
cord-006860-a3b8hyyr	2565	7	from	from	IN
cord-006860-a3b8hyyr	2565	8	77	77	CD
cord-006860-a3b8hyyr	2565	9	to	to	IN
cord-006860-a3b8hyyr	2565	10	239	239	CD
cord-006860-a3b8hyyr	2565	11	Gpt/1	Gpt/1	NNP
cord-006860-a3b8hyyr	2565	12	within	within	IN
cord-006860-a3b8hyyr	2565	13	5	5	CD
cord-006860-a3b8hyyr	2565	14	days	day	NNS
cord-006860-a3b8hyyr	2565	15	.	.	.
cord-006860-a3b8hyyr	2566	1	On	on	IN
cord-006860-a3b8hyyr	2566	2	day	day	NN
cord-006860-a3b8hyyr	2566	3	12	12	CD
cord-006860-a3b8hyyr	2566	4	complete	complete	JJ
cord-006860-a3b8hyyr	2566	5	reperfusion	reperfusion	NN
cord-006860-a3b8hyyr	2566	6	was	be	VBD
cord-006860-a3b8hyyr	2566	7	achieved	achieve	VBN
cord-006860-a3b8hyyr	2566	8	and	and	CC
cord-006860-a3b8hyyr	2566	9	rt	rt	NNP
cord-006860-a3b8hyyr	2566	10	-	-	HYPH
cord-006860-a3b8hyyr	2566	11	PA	PA	NNP
cord-006860-a3b8hyyr	2566	12	was	be	VBD
cord-006860-a3b8hyyr	2566	13	discontinued	discontinue	VBN
cord-006860-a3b8hyyr	2566	14	,	,	,
cord-006860-a3b8hyyr	2566	15	on	on	IN
cord-006860-a3b8hyyr	2566	16	day	day	NN
cord-006860-a3b8hyyr	2566	17	14	14	CD
cord-006860-a3b8hyyr	2566	18	.	.	.
cord-006860-a3b8hyyr	2567	1	The	the	DT
cord-006860-a3b8hyyr	2567	2	patient	patient	NN
cord-006860-a3b8hyyr	2567	3	was	be	VBD
cord-006860-a3b8hyyr	2567	4	discharged	discharge	VBN
cord-006860-a3b8hyyr	2567	5	from	from	IN
cord-006860-a3b8hyyr	2567	6	the	the	DT
cord-006860-a3b8hyyr	2567	7	hospital	hospital	NN
cord-006860-a3b8hyyr	2567	8	on	on	IN
cord-006860-a3b8hyyr	2567	9	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2567	10	with	with	IN
cord-006860-a3b8hyyr	2567	11	phenprocomnon	phenprocomnon	NN
cord-006860-a3b8hyyr	2567	12	in	in	IN
cord-006860-a3b8hyyr	2567	13	good	good	JJ
cord-006860-a3b8hyyr	2567	14	general	general	JJ
cord-006860-a3b8hyyr	2567	15	condition	condition	NN
cord-006860-a3b8hyyr	2567	16	At	at	IN
cord-006860-a3b8hyyr	2567	17	admission	admission	NN
cord-006860-a3b8hyyr	2567	18	thrombophilia	thrombophilia	NN
cord-006860-a3b8hyyr	2567	19	parameters	parameter	NNS
cord-006860-a3b8hyyr	2567	20	(	(	-LRB-
cord-006860-a3b8hyyr	2567	21	Protein	Protein	NNP
cord-006860-a3b8hyyr	2567	22	C	C	NNP
cord-006860-a3b8hyyr	2567	23	and	and	CC
cord-006860-a3b8hyyr	2567	24	S	S	NNP
cord-006860-a3b8hyyr	2567	25	,	,	,
cord-006860-a3b8hyyr	2567	26	APC	APC	NNP
cord-006860-a3b8hyyr	2567	27	)	)	-RRB-
cord-006860-a3b8hyyr	2567	28	were	be	VBD
cord-006860-a3b8hyyr	2567	29	within	within	IN
cord-006860-a3b8hyyr	2567	30	normal	normal	JJ
cord-006860-a3b8hyyr	2567	31	range	range	NN
cord-006860-a3b8hyyr	2567	32	.	.	.
cord-006860-a3b8hyyr	2568	1	Heparin	heparin	NN
cord-006860-a3b8hyyr	2568	2	induced	induce	VBN
cord-006860-a3b8hyyr	2568	3	thrombocgopenia	thrombocgopenia	NN
cord-006860-a3b8hyyr	2568	4	(	(	-LRB-
cord-006860-a3b8hyyr	2568	5	HIT	hit	NN
cord-006860-a3b8hyyr	2568	6	)	)	-RRB-
cord-006860-a3b8hyyr	2568	7	is	be	VBZ
cord-006860-a3b8hyyr	2568	8	a	a	DT
cord-006860-a3b8hyyr	2568	9	serious	serious	JJ
cord-006860-a3b8hyyr	2568	10	but	but	CC
cord-006860-a3b8hyyr	2568	11	rare	rare	JJ
cord-006860-a3b8hyyr	2568	12	side	side	NN
cord-006860-a3b8hyyr	2568	13	effect	effect	NN
cord-006860-a3b8hyyr	2568	14	of	of	IN
cord-006860-a3b8hyyr	2568	15	treatment	treatment	NN
cord-006860-a3b8hyyr	2568	16	with	with	IN
cord-006860-a3b8hyyr	2568	17	unfractionated	unfractionated	JJ
cord-006860-a3b8hyyr	2568	18	heparin	heparin	NNP
cord-006860-a3b8hyyr	2568	19	.	.	.
cord-006860-a3b8hyyr	2569	1	Patients	patient	NNS
cord-006860-a3b8hyyr	2569	2	with	with	IN
cord-006860-a3b8hyyr	2569	3	HIT	hit	NN
cord-006860-a3b8hyyr	2569	4	present	present	JJ
cord-006860-a3b8hyyr	2569	5	with	with	IN
cord-006860-a3b8hyyr	2569	6	a	a	DT
cord-006860-a3b8hyyr	2569	7	rapid	rapid	JJ
cord-006860-a3b8hyyr	2569	8	decrease	decrease	NN
cord-006860-a3b8hyyr	2569	9	in	in	IN
cord-006860-a3b8hyyr	2569	10	thrombocyte	thrombocyte	NNP
cord-006860-a3b8hyyr	2569	11	count	count	NN
cord-006860-a3b8hyyr	2569	12	and	and	CC
cord-006860-a3b8hyyr	2569	13	occurence	occurence	NN
cord-006860-a3b8hyyr	2569	14	of	of	IN
cord-006860-a3b8hyyr	2569	15	venous	venous	JJ
cord-006860-a3b8hyyr	2569	16	or	or	CC
cord-006860-a3b8hyyr	2569	17	arterial	arterial	JJ
cord-006860-a3b8hyyr	2569	18	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2569	19	under	under	IN
cord-006860-a3b8hyyr	2569	20	heparin	heparin	JJ
cord-006860-a3b8hyyr	2569	21	treatment	treatment	NN
cord-006860-a3b8hyyr	2569	22	.	.	.
cord-006860-a3b8hyyr	2570	1	Patients	patient	NNS
cord-006860-a3b8hyyr	2570	2	with	with	IN
cord-006860-a3b8hyyr	2570	3	arterial	arterial	JJ
cord-006860-a3b8hyyr	2570	4	occlusive	occlusive	JJ
cord-006860-a3b8hyyr	2570	5	disease	disease	NN
cord-006860-a3b8hyyr	2570	6	who	who	WP
cord-006860-a3b8hyyr	2570	7	need	need	VBP
cord-006860-a3b8hyyr	2570	8	surgical	surgical	JJ
cord-006860-a3b8hyyr	2570	9	intervention	intervention	NN
cord-006860-a3b8hyyr	2570	10	are	be	VBP
cord-006860-a3b8hyyr	2570	11	of	of	IN
cord-006860-a3b8hyyr	2570	12	high	high	JJ
cord-006860-a3b8hyyr	2570	13	risk	risk	NN
cord-006860-a3b8hyyr	2570	14	to	to	TO
cord-006860-a3b8hyyr	2570	15	develop	develop	VB
cord-006860-a3b8hyyr	2570	16	rethrombosis	rethrombosis	NN
cord-006860-a3b8hyyr	2570	17	especially	especially	RB
cord-006860-a3b8hyyr	2570	18	during	during	IN
cord-006860-a3b8hyyr	2570	19	the	the	DT
cord-006860-a3b8hyyr	2570	20	first	first	JJ
cord-006860-a3b8hyyr	2570	21	few	few	JJ
cord-006860-a3b8hyyr	2570	22	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	2570	23	days	day	NNS
cord-006860-a3b8hyyr	2570	24	while	while	IN
cord-006860-a3b8hyyr	2570	25	they	-PRON-	PRP
cord-006860-a3b8hyyr	2570	26	are	be	VBP
cord-006860-a3b8hyyr	2570	27	under	under	IN
cord-006860-a3b8hyyr	2570	28	i.v	i.v	NNP
cord-006860-a3b8hyyr	2570	29	.	.	.
cord-006860-a3b8hyyr	2570	30	heparin	heparin	NN
cord-006860-a3b8hyyr	2570	31	-	-	HYPH
cord-006860-a3b8hyyr	2570	32	treatment	treatment	NN
cord-006860-a3b8hyyr	2570	33	.	.	.
cord-006860-a3b8hyyr	2571	1	In	in	IN
cord-006860-a3b8hyyr	2571	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2571	3	study	study	NN
cord-006860-a3b8hyyr	2571	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	2571	5	investigated	investigate	VBD
cord-006860-a3b8hyyr	2571	6	prospectively	prospectively	RB
cord-006860-a3b8hyyr	2571	7	all	all	DT
cord-006860-a3b8hyyr	2571	8	patients	patient	NNS
cord-006860-a3b8hyyr	2571	9	who	who	WP
cord-006860-a3b8hyyr	2571	10	were	be	VBD
cord-006860-a3b8hyyr	2571	11	admitted	admit	VBN
cord-006860-a3b8hyyr	2571	12	to	to	IN
cord-006860-a3b8hyyr	2571	13	a	a	DT
cord-006860-a3b8hyyr	2571	14	surgical	surgical	JJ
cord-006860-a3b8hyyr	2571	15	unit	unit	NN
cord-006860-a3b8hyyr	2571	16	because	because	IN
cord-006860-a3b8hyyr	2571	17	of	of	IN
cord-006860-a3b8hyyr	2571	18	arterial	arterial	JJ
cord-006860-a3b8hyyr	2571	19	occlusive	occlusive	JJ
cord-006860-a3b8hyyr	2571	20	disease	disease	NN
cord-006860-a3b8hyyr	2571	21	and	and	CC
cord-006860-a3b8hyyr	2571	22	received	receive	VBD
cord-006860-a3b8hyyr	2571	23	surgical	surgical	JJ
cord-006860-a3b8hyyr	2571	24	intervention	intervention	NN
cord-006860-a3b8hyyr	2571	25	.	.	.
cord-006860-a3b8hyyr	2572	1	15	15	CD
cord-006860-a3b8hyyr	2572	2	patients	patient	NNS
cord-006860-a3b8hyyr	2572	3	were	be	VBD
cord-006860-a3b8hyyr	2572	4	screened	screen	VBN
cord-006860-a3b8hyyr	2572	5	on	on	IN
cord-006860-a3b8hyyr	2572	6	the	the	DT
cord-006860-a3b8hyyr	2572	7	3rd	3rd	JJ
cord-006860-a3b8hyyr	2572	8	and	and	CC
cord-006860-a3b8hyyr	2572	9	6th	6th	JJ
cord-006860-a3b8hyyr	2572	10	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	2572	11	day	day	NN
cord-006860-a3b8hyyr	2572	12	for	for	IN
cord-006860-a3b8hyyr	2572	13	heparin	heparin	NN
cord-006860-a3b8hyyr	2572	14	-	-	HYPH
cord-006860-a3b8hyyr	2572	15	antiplatelet	antiplatelet	NN
cord-006860-a3b8hyyr	2572	16	4-antibodies	4-antibodies	CD
cord-006860-a3b8hyyr	2572	17	,	,	,
cord-006860-a3b8hyyr	2572	18	decrease	decrease	NN
cord-006860-a3b8hyyr	2572	19	in	in	IN
cord-006860-a3b8hyyr	2572	20	platelet	platelet	NN
cord-006860-a3b8hyyr	2572	21	count	count	NN
cord-006860-a3b8hyyr	2572	22	and	and	CC
cord-006860-a3b8hyyr	2572	23	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	2572	24	complications	complication	NNS
cord-006860-a3b8hyyr	2572	25	.	.	.
cord-006860-a3b8hyyr	2573	1	3	3	CD
cord-006860-a3b8hyyr	2573	2	patients	patient	NNS
cord-006860-a3b8hyyr	2573	3	developed	develop	VBD
cord-006860-a3b8hyyr	2573	4	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2573	5	against	against	IN
cord-006860-a3b8hyyr	2573	6	heparin	heparin	NN
cord-006860-a3b8hyyr	2573	7	-	-	HYPH
cord-006860-a3b8hyyr	2573	8	platelet	platelet	NN
cord-006860-a3b8hyyr	2573	9	factor	factor	NN
cord-006860-a3b8hyyr	2573	10	4	4	CD
cord-006860-a3b8hyyr	2573	11	.	.	.
cord-006860-a3b8hyyr	2574	1	One	one	CD
cord-006860-a3b8hyyr	2574	2	of	of	IN
cord-006860-a3b8hyyr	2574	3	the	the	DT
cord-006860-a3b8hyyr	2574	4	3	3	CD
cord-006860-a3b8hyyr	2574	5	patients	patient	NNS
cord-006860-a3b8hyyr	2574	6	developed	develop	VBD
cord-006860-a3b8hyyr	2574	7	a	a	DT
cord-006860-a3b8hyyr	2574	8	venous	venous	JJ
cord-006860-a3b8hyyr	2574	9	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2574	10	in	in	IN
cord-006860-a3b8hyyr	2574	11	the	the	DT
cord-006860-a3b8hyyr	2574	12	operated	operate	VBN
cord-006860-a3b8hyyr	2574	13	leg	leg	NN
cord-006860-a3b8hyyr	2574	14	in	in	IN
cord-006860-a3b8hyyr	2574	15	combination	combination	NN
cord-006860-a3b8hyyr	2574	16	with	with	IN
cord-006860-a3b8hyyr	2574	17	a	a	DT
cord-006860-a3b8hyyr	2574	18	decrease	decrease	NN
cord-006860-a3b8hyyr	2574	19	in	in	IN
cord-006860-a3b8hyyr	2574	20	thrombocyte	thrombocyte	NNP
cord-006860-a3b8hyyr	2574	21	count	count	NN
cord-006860-a3b8hyyr	2574	22	.	.	.
cord-006860-a3b8hyyr	2575	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2575	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	2575	3	that	that	IN
cord-006860-a3b8hyyr	2575	4	heparin	heparin	NN
cord-006860-a3b8hyyr	2575	5	-	-	HYPH
cord-006860-a3b8hyyr	2575	6	platelet	platelet	NN
cord-006860-a3b8hyyr	2575	7	factor	factor	NN
cord-006860-a3b8hyyr	2575	8	4-antibodies	4-antibodies	CD
cord-006860-a3b8hyyr	2575	9	are	be	VBP
cord-006860-a3b8hyyr	2575	10	often	often	RB
cord-006860-a3b8hyyr	2575	11	produced	produce	VBN
cord-006860-a3b8hyyr	2575	12	in	in	IN
cord-006860-a3b8hyyr	2575	13	patients	patient	NNS
cord-006860-a3b8hyyr	2575	14	under	under	IN
cord-006860-a3b8hyyr	2575	15	i.v	i.v	NNP
cord-006860-a3b8hyyr	2575	16	.	.	.
cord-006860-a3b8hyyr	2575	17	heparin	heparin	NNP
cord-006860-a3b8hyyr	2575	18	treatment	treatment	NN
cord-006860-a3b8hyyr	2575	19	.	.	.
cord-006860-a3b8hyyr	2576	1	Only	only	RB
cord-006860-a3b8hyyr	2576	2	few	few	JJ
cord-006860-a3b8hyyr	2576	3	of	of	IN
cord-006860-a3b8hyyr	2576	4	these	these	DT
cord-006860-a3b8hyyr	2576	5	patients	patient	NNS
cord-006860-a3b8hyyr	2576	6	actually	actually	RB
cord-006860-a3b8hyyr	2576	7	suffer	suffer	VBP
cord-006860-a3b8hyyr	2576	8	from	from	IN
cord-006860-a3b8hyyr	2576	9	clinically	clinically	RB
cord-006860-a3b8hyyr	2576	10	s3anptomatic	s3anptomatic	NNP
cord-006860-a3b8hyyr	2576	11	HIT	HIT	NNP
cord-006860-a3b8hyyr	2576	12	.	.	.
cord-006860-a3b8hyyr	2577	1	Medizinische	Medizinische	NNP
cord-006860-a3b8hyyr	2577	2	Universit	Universit	NNP
cord-006860-a3b8hyyr	2577	3	~	~	NFP
cord-006860-a3b8hyyr	2577	4	itsklinik	itsklinik	NNP
cord-006860-a3b8hyyr	2578	1	,	,	,
cord-006860-a3b8hyyr	2578	2	Institut	Institut	NNP
cord-006860-a3b8hyyr	2578	3	far	far	RB
cord-006860-a3b8hyyr	2578	4	Klinische	Klinische	NNP
cord-006860-a3b8hyyr	2578	5	Biochemie	Biochemie	NNP
cord-006860-a3b8hyyr	2578	6	und	und	IN
cord-006860-a3b8hyyr	2578	7	Pathobiochemie	Pathobiochemie	NNP
cord-006860-a3b8hyyr	2578	8	,	,	,
cord-006860-a3b8hyyr	2579	1	D-97080	D-97080	NNP
cord-006860-a3b8hyyr	2580	1	Wtirzburg	Wtirzburg	NNP
cord-006860-a3b8hyyr	2580	2	,	,	,
cord-006860-a3b8hyyr	2580	3	Germany	Germany	NNP
cord-006860-a3b8hyyr	2581	1	The	the	DT
cord-006860-a3b8hyyr	2581	2	important	important	JJ
cord-006860-a3b8hyyr	2581	3	physiological	physiological	JJ
cord-006860-a3b8hyyr	2581	4	and	and	CC
cord-006860-a3b8hyyr	2581	5	pathophysiological	pathophysiological	JJ
cord-006860-a3b8hyyr	2581	6	role	role	NN
cord-006860-a3b8hyyr	2581	7	of	of	IN
cord-006860-a3b8hyyr	2581	8	platetets	platetet	NNS
cord-006860-a3b8hyyr	2581	9	in	in	IN
cord-006860-a3b8hyyr	2581	10	health	health	NN
cord-006860-a3b8hyyr	2581	11	and	and	CC
cord-006860-a3b8hyyr	2581	12	disease	disease	NN
cord-006860-a3b8hyyr	2581	13	is	be	VBZ
cord-006860-a3b8hyyr	2581	14	well	well	RB
cord-006860-a3b8hyyr	2581	15	established	establish	VBN
cord-006860-a3b8hyyr	2581	16	.	.	.
cord-006860-a3b8hyyr	2582	1	Platelets	platelet	NNS
cord-006860-a3b8hyyr	2582	2	are	be	VBP
cord-006860-a3b8hyyr	2582	3	also	also	RB
cord-006860-a3b8hyyr	2582	4	the	the	DT
cord-006860-a3b8hyyr	2582	5	primary	primary	JJ
cord-006860-a3b8hyyr	2582	6	target	target	NN
cord-006860-a3b8hyyr	2582	7	of	of	IN
cord-006860-a3b8hyyr	2582	8	many	many	JJ
cord-006860-a3b8hyyr	2582	9	vasoactive	vasoactive	JJ
cord-006860-a3b8hyyr	2582	10	hormones	hormone	NNS
cord-006860-a3b8hyyr	2582	11	,	,	,
cord-006860-a3b8hyyr	2582	12	factors	factor	NNS
cord-006860-a3b8hyyr	2582	13	and	and	CC
cord-006860-a3b8hyyr	2582	14	drugs	drug	NNS
cord-006860-a3b8hyyr	2582	15	.	.	.
cord-006860-a3b8hyyr	2583	1	In	in	IN
cord-006860-a3b8hyyr	2583	2	addition	addition	NN
cord-006860-a3b8hyyr	2583	3	,	,	,
cord-006860-a3b8hyyr	2583	4	platelets	platelet	NNS
cord-006860-a3b8hyyr	2583	5	provide	provide	VBP
cord-006860-a3b8hyyr	2583	6	a	a	DT
cord-006860-a3b8hyyr	2583	7	very	very	RB
cord-006860-a3b8hyyr	2583	8	important	important	JJ
cord-006860-a3b8hyyr	2583	9	model	model	NN
cord-006860-a3b8hyyr	2583	10	system	system	NN
cord-006860-a3b8hyyr	2583	11	for	for	IN
cord-006860-a3b8hyyr	2583	12	studying	study	VBG
cord-006860-a3b8hyyr	2583	13	agonist	agonist	NN
cord-006860-a3b8hyyr	2583	14	-	-	:
cord-006860-a3b8hyyr	2583	15	and	and	CC
cord-006860-a3b8hyyr	2583	16	antagonist	antagonist	NN
cord-006860-a3b8hyyr	2583	17	-	-	HYPH
cord-006860-a3b8hyyr	2583	18	mediated	mediate	VBN
cord-006860-a3b8hyyr	2583	19	signal	signal	NN
cord-006860-a3b8hyyr	2583	20	transduction	transduction	NN
cord-006860-a3b8hyyr	2583	21	events	event	NNS
cord-006860-a3b8hyyr	2583	22	(	(	-LRB-
cord-006860-a3b8hyyr	2583	23	1,2	1,2	CD
cord-006860-a3b8hyyr	2583	24	)	)	-RRB-
cord-006860-a3b8hyyr	2583	25	.	.	.
cord-006860-a3b8hyyr	2584	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	2584	2	activation	activation	NN
cord-006860-a3b8hyyr	2584	3	by	by	IN
cord-006860-a3b8hyyr	2584	4	agonists	agonist	NNS
cord-006860-a3b8hyyr	2584	5	is	be	VBZ
cord-006860-a3b8hyyr	2584	6	associated	associate	VBN
cord-006860-a3b8hyyr	2584	7	with	with	IN
cord-006860-a3b8hyyr	2584	8	shape	shape	NN
cord-006860-a3b8hyyr	2584	9	change	change	NN
cord-006860-a3b8hyyr	2584	10	,	,	,
cord-006860-a3b8hyyr	2584	11	extension	extension	NN
cord-006860-a3b8hyyr	2584	12	of	of	IN
cord-006860-a3b8hyyr	2584	13	filopodia	filopodia	NNS
cord-006860-a3b8hyyr	2584	14	,	,	,
cord-006860-a3b8hyyr	2584	15	generation	generation	NN
cord-006860-a3b8hyyr	2584	16	of	of	IN
cord-006860-a3b8hyyr	2584	17	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	2584	18	messengers	messenger	NNS
cord-006860-a3b8hyyr	2584	19	,	,	,
cord-006860-a3b8hyyr	2584	20	secondary	secondary	JJ
cord-006860-a3b8hyyr	2584	21	agonists	agonist	NNS
cord-006860-a3b8hyyr	2584	22	and	and	CC
cord-006860-a3b8hyyr	2584	23	activation	activation	NN
cord-006860-a3b8hyyr	2584	24	of	of	IN
cord-006860-a3b8hyyr	2584	25	adhesion	adhesion	NN
cord-006860-a3b8hyyr	2584	26	receptors	receptor	NNS
cord-006860-a3b8hyyr	2584	27	and	and	CC
cord-006860-a3b8hyyr	2584	28	integrins	integrin	NNS
cord-006860-a3b8hyyr	2584	29	including	include	VBG
cord-006860-a3b8hyyr	2584	30	the	the	DT
cord-006860-a3b8hyyr	2584	31	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	2584	32	receptor	receptor	NN
cord-006860-a3b8hyyr	2584	33	GP	GP	NNP
cord-006860-a3b8hyyr	2584	34	IIb	IIb	NNP
cord-006860-a3b8hyyr	2584	35	/	/	SYM
cord-006860-a3b8hyyr	2584	36	IIIa	iiia	NN
cord-006860-a3b8hyyr	2584	37	.	.	.
cord-006860-a3b8hyyr	2585	1	Activation	activation	NN
cord-006860-a3b8hyyr	2585	2	of	of	IN
cord-006860-a3b8hyyr	2585	3	protein	protein	NN
cord-006860-a3b8hyyr	2585	4	tyrosine	tyrosine	NN
cord-006860-a3b8hyyr	2585	5	ldnases	ldnase	NNS
cord-006860-a3b8hyyr	2585	6	and	and	CC
cord-006860-a3b8hyyr	2585	7	calcium	calcium	NN
cord-006860-a3b8hyyr	2585	8	-	-	HYPH
cord-006860-a3b8hyyr	2585	9	dependent	dependent	JJ
cord-006860-a3b8hyyr	2585	10	protein	protein	NN
cord-006860-a3b8hyyr	2585	11	kinases	kinase	NNS
cord-006860-a3b8hyyr	2585	12	appear	appear	VBP
cord-006860-a3b8hyyr	2585	13	to	to	TO
cord-006860-a3b8hyyr	2585	14	be	be	VB
cord-006860-a3b8hyyr	2585	15	of	of	IN
cord-006860-a3b8hyyr	2585	16	critical	critical	JJ
cord-006860-a3b8hyyr	2585	17	importance	importance	NN
cord-006860-a3b8hyyr	2585	18	for	for	IN
cord-006860-a3b8hyyr	2585	19	the	the	DT
cord-006860-a3b8hyyr	2585	20	mechanism	mechanism	NN
cord-006860-a3b8hyyr	2585	21	of	of	IN
cord-006860-a3b8hyyr	2585	22	platelet	platelet	NN
cord-006860-a3b8hyyr	2585	23	activation	activation	NN
cord-006860-a3b8hyyr	2585	24	.	.	.
cord-006860-a3b8hyyr	2586	1	In	in	IN
cord-006860-a3b8hyyr	2586	2	contrast	contrast	NN
cord-006860-a3b8hyyr	2586	3	,	,	,
cord-006860-a3b8hyyr	2586	4	platelet	platelet	NN
cord-006860-a3b8hyyr	2586	5	inhibition	inhibition	NN
cord-006860-a3b8hyyr	2586	6	by	by	IN
cord-006860-a3b8hyyr	2586	7	vasoactive	vasoactive	JJ
cord-006860-a3b8hyyr	2586	8	factors	factor	NNS
cord-006860-a3b8hyyr	2586	9	and	and	CC
cord-006860-a3b8hyyr	2586	10	drugs	drug	NNS
cord-006860-a3b8hyyr	2586	11	is	be	VBZ
cord-006860-a3b8hyyr	2586	12	often	often	RB
cord-006860-a3b8hyyr	2586	13	mediated	mediate	VBN
cord-006860-a3b8hyyr	2586	14	by	by	IN
cord-006860-a3b8hyyr	2586	15	the	the	DT
cord-006860-a3b8hyyr	2586	16	cAMP	camp	NN
cord-006860-a3b8hyyr	2586	17	and/or	and/or	CC
cord-006860-a3b8hyyr	2586	18	cGMP	cGMP	NNP
cord-006860-a3b8hyyr	2586	19	signal	signal	NN
cord-006860-a3b8hyyr	2586	20	transduction	transduction	NN
cord-006860-a3b8hyyr	2586	21	cascades	cascade	NNS
cord-006860-a3b8hyyr	2586	22	.	.	.
cord-006860-a3b8hyyr	2587	1	Recent	recent	JJ
cord-006860-a3b8hyyr	2587	2	data	datum	NNS
cord-006860-a3b8hyyr	2587	3	form	form	VBP
cord-006860-a3b8hyyr	2587	4	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2587	5	laboratory	laboratory	NN
cord-006860-a3b8hyyr	2587	6	suggest	suggest	VBP
cord-006860-a3b8hyyr	2587	7	that	that	IN
cord-006860-a3b8hyyr	2587	8	the	the	DT
cord-006860-a3b8hyyr	2587	9	focal	focal	JJ
cord-006860-a3b8hyyr	2587	10	adhesion	adhesion	NN
cord-006860-a3b8hyyr	2587	11	protein	protein	NN
cord-006860-a3b8hyyr	2587	12	VASP	VASP	NNP
cord-006860-a3b8hyyr	2587	13	,	,	,
cord-006860-a3b8hyyr	2587	14	a	a	DT
cord-006860-a3b8hyyr	2587	15	major	major	JJ
cord-006860-a3b8hyyr	2587	16	target	target	NN
cord-006860-a3b8hyyr	2587	17	of	of	IN
cord-006860-a3b8hyyr	2587	18	the	the	DT
cord-006860-a3b8hyyr	2587	19	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	2587	20	NO	NO	NNP
cord-006860-a3b8hyyr	2587	21	/	/	SYM
cord-006860-a3b8hyyr	2587	22	cGMP	cGMP	NNP
cord-006860-a3b8hyyr	2587	23	and	and	CC
cord-006860-a3b8hyyr	2587	24	prostacyclin	prostacyclin	NNP
cord-006860-a3b8hyyr	2587	25	/	/	SYM
cord-006860-a3b8hyyr	2587	26	cAMP	camp	NN
cord-006860-a3b8hyyr	2587	27	effector	effector	JJ
cord-006860-a3b8hyyr	2587	28	systems	system	NNS
cord-006860-a3b8hyyr	2587	29	,	,	,
cord-006860-a3b8hyyr	2587	30	is	be	VBZ
cord-006860-a3b8hyyr	2587	31	an	an	DT
cord-006860-a3b8hyyr	2587	32	important	important	JJ
cord-006860-a3b8hyyr	2587	33	link	link	NN
cord-006860-a3b8hyyr	2587	34	between	between	IN
cord-006860-a3b8hyyr	2587	35	signal	signal	NN
cord-006860-a3b8hyyr	2587	36	transduction	transduction	NN
cord-006860-a3b8hyyr	2587	37	pathways	pathway	NNS
cord-006860-a3b8hyyr	2587	38	and	and	CC
cord-006860-a3b8hyyr	2587	39	elements	element	NNS
cord-006860-a3b8hyyr	2587	40	controlling	control	VBG
cord-006860-a3b8hyyr	2587	41	cell	cell	NN
cord-006860-a3b8hyyr	2587	42	motility	motility	NN
cord-006860-a3b8hyyr	2587	43	(	(	-LRB-
cord-006860-a3b8hyyr	2587	44	3	3	CD
cord-006860-a3b8hyyr	2587	45	-	-	SYM
cord-006860-a3b8hyyr	2587	46	6	6	CD
cord-006860-a3b8hyyr	2587	47	)	)	-RRB-
cord-006860-a3b8hyyr	2587	48	.	.	.
cord-006860-a3b8hyyr	2588	1	The	the	DT
cord-006860-a3b8hyyr	2588	2	implications	implication	NNS
cord-006860-a3b8hyyr	2588	3	of	of	IN
cord-006860-a3b8hyyr	2588	4	the	the	DT
cord-006860-a3b8hyyr	2588	5	recent	recent	JJ
cord-006860-a3b8hyyr	2588	6	advances	advance	NNS
cord-006860-a3b8hyyr	2588	7	in	in	IN
cord-006860-a3b8hyyr	2588	8	platelet	platelet	NN
cord-006860-a3b8hyyr	2588	9	signal	signal	NN
cord-006860-a3b8hyyr	2588	10	transduction	transduction	NN
cord-006860-a3b8hyyr	2588	11	research	research	NN
cord-006860-a3b8hyyr	2588	12	for	for	IN
cord-006860-a3b8hyyr	2588	13	understanding	understand	VBG
cord-006860-a3b8hyyr	2588	14	the	the	DT
cord-006860-a3b8hyyr	2588	15	physiology	physiology	NN
cord-006860-a3b8hyyr	2588	16	,	,	,
cord-006860-a3b8hyyr	2588	17	pathophysiology	pathophysiology	NN
cord-006860-a3b8hyyr	2588	18	and	and	CC
cord-006860-a3b8hyyr	2588	19	pharmacology	pharmacology	NN
cord-006860-a3b8hyyr	2588	20	of	of	IN
cord-006860-a3b8hyyr	2588	21	human	human	JJ
cord-006860-a3b8hyyr	2588	22	platelets	platelet	NNS
cord-006860-a3b8hyyr	2588	23	will	will	MD
cord-006860-a3b8hyyr	2588	24	be	be	VB
cord-006860-a3b8hyyr	2588	25	discussed	discuss	VBN
cord-006860-a3b8hyyr	2588	26	.	.	.
cord-006860-a3b8hyyr	2589	1	domain	domain	NN
cord-006860-a3b8hyyr	2589	2	.	.	.
cord-006860-a3b8hyyr	2590	1	However	however	RB
cord-006860-a3b8hyyr	2590	2	,	,	,
cord-006860-a3b8hyyr	2590	3	in	in	IN
cord-006860-a3b8hyyr	2590	4	vivo	vivo	FW
cord-006860-a3b8hyyr	2590	5	truncated	truncate	VBN
cord-006860-a3b8hyyr	2590	6	"	"	''
cord-006860-a3b8hyyr	2590	7	I'PO	I'PO	NNP
cord-006860-a3b8hyyr	2590	8	is	be	VBZ
cord-006860-a3b8hyyr	2590	9	much	much	RB
cord-006860-a3b8hyyr	2590	10	less	less	RBR
cord-006860-a3b8hyyr	2590	11	potent	potent	JJ
cord-006860-a3b8hyyr	2590	12	than	than	IN
cord-006860-a3b8hyyr	2590	13	full	full	JJ
cord-006860-a3b8hyyr	2590	14	length	length	NN
cord-006860-a3b8hyyr	2590	15	TPO	tpo	NN
cord-006860-a3b8hyyr	2590	16	due	due	IN
cord-006860-a3b8hyyr	2590	17	to	to	IN
cord-006860-a3b8hyyr	2590	18	its	-PRON-	PRP$
cord-006860-a3b8hyyr	2590	19	rapid	rapid	JJ
cord-006860-a3b8hyyr	2590	20	clearance	clearance	NN
cord-006860-a3b8hyyr	2590	21	.	.	.
cord-006860-a3b8hyyr	2591	1	This	this	DT
cord-006860-a3b8hyyr	2591	2	suggest	suggest	VBP
cord-006860-a3b8hyyr	2591	3	that	that	IN
cord-006860-a3b8hyyr	2591	4	the	the	DT
cord-006860-a3b8hyyr	2591	5	C	C	NNP
cord-006860-a3b8hyyr	2591	6	-	-	HYPH
cord-006860-a3b8hyyr	2591	7	terminal	terminal	NN
cord-006860-a3b8hyyr	2591	8	glycosylated	glycosylated	JJ
cord-006860-a3b8hyyr	2591	9	domain	domain	NN
cord-006860-a3b8hyyr	2591	10	acts	act	VBZ
cord-006860-a3b8hyyr	2591	11	to	to	TO
cord-006860-a3b8hyyr	2591	12	stabilize	stabilize	VB
cord-006860-a3b8hyyr	2591	13	circulating	circulate	VBG
cord-006860-a3b8hyyr	2591	14	TPO	TPO	NNP
cord-006860-a3b8hyyr	2591	15	.	.	.
cord-006860-a3b8hyyr	2592	1	TPO	TPO	NNP
cord-006860-a3b8hyyr	2592	2	stimulates	stimulate	VBZ
cord-006860-a3b8hyyr	2592	3	both	both	DT
cord-006860-a3b8hyyr	2592	4	proliferation	proliferation	NN
cord-006860-a3b8hyyr	2592	5	of	of	IN
cord-006860-a3b8hyyr	2592	6	progenitor	progenitor	NN
cord-006860-a3b8hyyr	2592	7	megakaryocytes	megakaryocyte	NNS
cord-006860-a3b8hyyr	2592	8	and	and	CC
cord-006860-a3b8hyyr	2592	9	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2592	10	maturation	maturation	NN
cord-006860-a3b8hyyr	2592	11	to	to	TO
cord-006860-a3b8hyyr	2592	12	platelet	platelet	NN
cord-006860-a3b8hyyr	2592	13	producing	produce	VBG
cord-006860-a3b8hyyr	2592	14	megakaryocytes	megakaryocyte	NNS
cord-006860-a3b8hyyr	2592	15	in	in	IN
cord-006860-a3b8hyyr	2592	16	vitro	vitro	FW
cord-006860-a3b8hyyr	2592	17	.	.	.
cord-006860-a3b8hyyr	2593	1	In	in	IN
cord-006860-a3b8hyyr	2593	2	vivo	vivo	NN
cord-006860-a3b8hyyr	2593	3	TPO	TPO	NNP
cord-006860-a3b8hyyr	2593	4	induces	induce	VBZ
cord-006860-a3b8hyyr	2593	5	dramatic	dramatic	JJ
cord-006860-a3b8hyyr	2593	6	increa	increa	NNP
cord-006860-a3b8hyyr	2593	7	~	~	NFP
cord-006860-a3b8hyyr	2593	8	ses	ses	NNP
cord-006860-a3b8hyyr	2593	9	in	in	IN
cord-006860-a3b8hyyr	2593	10	megakaryocyte	megakaryocyte	NNP
cord-006860-a3b8hyyr	2593	11	number	number	NN
cord-006860-a3b8hyyr	2593	12	and	and	CC
cord-006860-a3b8hyyr	2593	13	platelet	platelet	NN
cord-006860-a3b8hyyr	2593	14	production	production	NN
cord-006860-a3b8hyyr	2593	15	in	in	IN
cord-006860-a3b8hyyr	2593	16	animals	animal	NNS
cord-006860-a3b8hyyr	2593	17	,	,	,
cord-006860-a3b8hyyr	2593	18	indicating	indicate	VBG
cord-006860-a3b8hyyr	2593	19	that	that	IN
cord-006860-a3b8hyyr	2593	20	TPO	TPO	NNP
cord-006860-a3b8hyyr	2593	21	regulates	regulate	VBZ
cord-006860-a3b8hyyr	2593	22	both	both	CC
cord-006860-a3b8hyyr	2593	23	thrombopoiesis	thrombopoiesis	NNP
cord-006860-a3b8hyyr	2593	24	and	and	CC
cord-006860-a3b8hyyr	2593	25	megakaryocytopoiesis	megakaryocytopoiesis	NNP
cord-006860-a3b8hyyr	2593	26	and	and	CC
cord-006860-a3b8hyyr	2593	27	is	be	VBZ
cord-006860-a3b8hyyr	2593	28	the	the	DT
cord-006860-a3b8hyyr	2593	29	primary	primary	JJ
cord-006860-a3b8hyyr	2593	30	regulator	regulator	NN
cord-006860-a3b8hyyr	2593	31	of	of	IN
cord-006860-a3b8hyyr	2593	32	physiological	physiological	JJ
cord-006860-a3b8hyyr	2593	33	platelet	platelet	NN
cord-006860-a3b8hyyr	2593	34	production	production	NN
cord-006860-a3b8hyyr	2593	35	.	.	.
cord-006860-a3b8hyyr	2594	1	This	this	DT
cord-006860-a3b8hyyr	2594	2	later	later	RB
cord-006860-a3b8hyyr	2594	3	notion	notion	NN
cord-006860-a3b8hyyr	2594	4	is	be	VBZ
cord-006860-a3b8hyyr	2594	5	supported	support	VBN
cord-006860-a3b8hyyr	2594	6	by	by	IN
cord-006860-a3b8hyyr	2594	7	the	the	DT
cord-006860-a3b8hyyr	2594	8	phenotype	phenotype	NN
cord-006860-a3b8hyyr	2594	9	of	of	IN
cord-006860-a3b8hyyr	2594	10	TI~	TI~	NNP
cord-006860-a3b8hyyr	2594	11	and	and	CC
cord-006860-a3b8hyyr	2594	12	cMpl	cMpl	NNP
cord-006860-a3b8hyyr	2594	13	knockout	knockout	NN
cord-006860-a3b8hyyr	2594	14	mice	mouse	NNS
cord-006860-a3b8hyyr	2594	15	in	in	IN
cord-006860-a3b8hyyr	2594	16	which	which	WDT
cord-006860-a3b8hyyr	2594	17	platelet	platelet	NN
cord-006860-a3b8hyyr	2594	18	levels	level	NNS
cord-006860-a3b8hyyr	2594	19	are	be	VBP
cord-006860-a3b8hyyr	2594	20	only	only	RB
cord-006860-a3b8hyyr	2594	21	10	10	CD
cord-006860-a3b8hyyr	2594	22	-	-	SYM
cord-006860-a3b8hyyr	2594	23	20	20	CD
cord-006860-a3b8hyyr	2594	24	%	%	NN
cord-006860-a3b8hyyr	2594	25	of	of	IN
cord-006860-a3b8hyyr	2594	26	normal	normal	JJ
cord-006860-a3b8hyyr	2594	27	while	while	IN
cord-006860-a3b8hyyr	2594	28	other	other	JJ
cord-006860-a3b8hyyr	2594	29	blood	blood	NN
cord-006860-a3b8hyyr	2594	30	lineages	lineage	NNS
cord-006860-a3b8hyyr	2594	31	are	be	VBP
cord-006860-a3b8hyyr	2594	32	unaffected	unaffected	JJ
cord-006860-a3b8hyyr	2594	33	.	.	.
cord-006860-a3b8hyyr	2595	1	In	in	IN
cord-006860-a3b8hyyr	2595	2	animal	animal	NN
cord-006860-a3b8hyyr	2595	3	models	model	NNS
cord-006860-a3b8hyyr	2595	4	of	of	IN
cord-006860-a3b8hyyr	2595	5	myetosuppresion	myetosuppresion	NN
cord-006860-a3b8hyyr	2595	6	,	,	,
cord-006860-a3b8hyyr	2595	7	and	and	CC
cord-006860-a3b8hyyr	2595	8	marrow	marrow	NN
cord-006860-a3b8hyyr	2595	9	transplant	transplant	NN
cord-006860-a3b8hyyr	2595	10	,	,	,
cord-006860-a3b8hyyr	2595	11	TPO	TPO	NNP
cord-006860-a3b8hyyr	2595	12	reduces	reduce	VBZ
cord-006860-a3b8hyyr	2595	13	the	the	DT
cord-006860-a3b8hyyr	2595	14	platelet	platelet	NN
cord-006860-a3b8hyyr	2595	15	nadir	nadir	NN
cord-006860-a3b8hyyr	2595	16	seen	see	VBN
cord-006860-a3b8hyyr	2595	17	in	in	IN
cord-006860-a3b8hyyr	2595	18	the	the	DT
cord-006860-a3b8hyyr	2595	19	~	~	NFP
cord-006860-a3b8hyyr	2595	20	se	se	FW
cord-006860-a3b8hyyr	2595	21	models	model	NNS
cord-006860-a3b8hyyr	2595	22	and	and	CC
cord-006860-a3b8hyyr	2595	23	significantly	significantly	RB
cord-006860-a3b8hyyr	2595	24	accelerates	accelerate	VBZ
cord-006860-a3b8hyyr	2595	25	platelet	platelet	NN
cord-006860-a3b8hyyr	2595	26	recovery	recovery	NN
cord-006860-a3b8hyyr	2595	27	,	,	,
cord-006860-a3b8hyyr	2595	28	TPO	TPO	NNP
cord-006860-a3b8hyyr	2595	29	also	also	RB
cord-006860-a3b8hyyr	2595	30	has	have	VBZ
cord-006860-a3b8hyyr	2595	31	profound	profound	JJ
cord-006860-a3b8hyyr	2595	32	effects	effect	NNS
cord-006860-a3b8hyyr	2595	33	on	on	IN
cord-006860-a3b8hyyr	2595	34	red	red	JJ
cord-006860-a3b8hyyr	2595	35	cell	cell	NN
cord-006860-a3b8hyyr	2595	36	recovery	recovery	NN
cord-006860-a3b8hyyr	2595	37	in	in	IN
cord-006860-a3b8hyyr	2595	38	these	these	DT
cord-006860-a3b8hyyr	2595	39	models	model	NNS
cord-006860-a3b8hyyr	2595	40	.	.	.
cord-006860-a3b8hyyr	2596	1	These	these	DT
cord-006860-a3b8hyyr	2596	2	results	result	NNS
cord-006860-a3b8hyyr	2596	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	2596	4	that	that	IN
cord-006860-a3b8hyyr	2596	5	TPO	TPO	NNP
cord-006860-a3b8hyyr	2596	6	will	will	MD
cord-006860-a3b8hyyr	2596	7	be	be	VB
cord-006860-a3b8hyyr	2596	8	clinically	clinically	RB
cord-006860-a3b8hyyr	2596	9	u	u	NNP
cord-006860-a3b8hyyr	2596	10	~	~	NFP
cord-006860-a3b8hyyr	2596	11	ful	ful	XX
cord-006860-a3b8hyyr	2596	12	for	for	IN
cord-006860-a3b8hyyr	2596	13	the	the	DT
cord-006860-a3b8hyyr	2596	14	treatment	treatment	NN
cord-006860-a3b8hyyr	2596	15	of	of	IN
cord-006860-a3b8hyyr	2596	16	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2596	17	in	in	IN
cord-006860-a3b8hyyr	2596	18	caucer	caucer	NN
cord-006860-a3b8hyyr	2596	19	patients	patient	NNS
cord-006860-a3b8hyyr	2596	20	who	who	WP
cord-006860-a3b8hyyr	2596	21	undergo	undergo	VBP
cord-006860-a3b8hyyr	2596	22	chemotherapy	chemotherapy	NN
cord-006860-a3b8hyyr	2596	23	or	or	CC
cord-006860-a3b8hyyr	2596	24	bone	bone	NN
cord-006860-a3b8hyyr	2596	25	marrow	marrow	NN
cord-006860-a3b8hyyr	2596	26	transplant	transplant	NN
cord-006860-a3b8hyyr	2596	27	.	.	.
cord-006860-a3b8hyyr	2597	1	The	the	DT
cord-006860-a3b8hyyr	2597	2	HAPARG	HAPARG	NNP
cord-006860-a3b8hyyr	2597	3	-	-	HYPH
cord-006860-a3b8hyyr	2597	4	study	study	NN
cord-006860-a3b8hyyr	2597	5	(	(	-LRB-
cord-006860-a3b8hyyr	2597	6	.~a.emostatic	.~a.emostatic	.
cord-006860-a3b8hyyr	2598	1	Parameters	parameter	NNS
cord-006860-a3b8hyyr	2598	2	as	as	IN
cord-006860-a3b8hyyr	2598	3	Risk	risk	NN
cord-006860-a3b8hyyr	2598	4	factors	factor	NNS
cord-006860-a3b8hyyr	2598	5	in	in	IN
cord-006860-a3b8hyyr	2598	6	healthy	healthy	JJ
cord-006860-a3b8hyyr	2598	7	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	2598	8	)	)	-RRB-
cord-006860-a3b8hyyr	2598	9	was	be	VBD
cord-006860-a3b8hyyr	2598	10	sponsored	sponsor	VBN
cord-006860-a3b8hyyr	2598	11	by	by	IN
cord-006860-a3b8hyyr	2598	12	the	the	DT
cord-006860-a3b8hyyr	2598	13	German	German	NNP
cord-006860-a3b8hyyr	2598	14	Ministry	Ministry	NNP
cord-006860-a3b8hyyr	2598	15	of	of	IN
cord-006860-a3b8hyyr	2598	16	Research	Research	NNP
cord-006860-a3b8hyyr	2598	17	and	and	CC
cord-006860-a3b8hyyr	2598	18	started	start	VBD
cord-006860-a3b8hyyr	2598	19	in	in	IN
cord-006860-a3b8hyyr	2598	20	1984	1984	CD
cord-006860-a3b8hyyr	2598	21	.	.	.
cord-006860-a3b8hyyr	2599	1	A	a	DT
cord-006860-a3b8hyyr	2599	2	previous	previous	JJ
cord-006860-a3b8hyyr	2599	3	study	study	NN
cord-006860-a3b8hyyr	2599	4	(	(	-LRB-
cord-006860-a3b8hyyr	2599	5	PARD	PARD	NNP
cord-006860-a3b8hyyr	2599	6	,	,	,
cord-006860-a3b8hyyr	2599	7	Intern	Intern	NNP
cord-006860-a3b8hyyr	2599	8	.	.	.
cord-006860-a3b8hyyr	2600	1	Angiology	Angiology	NNP
cord-006860-a3b8hyyr	2600	2	5	5	CD
cord-006860-a3b8hyyr	2600	3	,	,	,
cord-006860-a3b8hyyr	2600	4	181	181	CD
cord-006860-a3b8hyyr	2600	5	-	-	HYPH
cord-006860-a3b8hyyr	2600	6	195,1986	195,1986	CD
cord-006860-a3b8hyyr	2600	7	)	)	-RRB-
cord-006860-a3b8hyyr	2600	8	had	have	VBD
cord-006860-a3b8hyyr	2600	9	shown	show	VBN
cord-006860-a3b8hyyr	2600	10	that	that	IN
cord-006860-a3b8hyyr	2600	11	spontaneously	spontaneously	RB
cord-006860-a3b8hyyr	2600	12	enhanced	enhance	VBN
cord-006860-a3b8hyyr	2600	13	platelet	platelet	NN
cord-006860-a3b8hyyr	2600	14	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2600	15	as	as	IN
cord-006860-a3b8hyyr	2600	16	measured	measure	VBN
cord-006860-a3b8hyyr	2600	17	with	with	IN
cord-006860-a3b8hyyr	2600	18	the	the	DT
cord-006860-a3b8hyyr	2600	19	PAT	PAT	NNP
cord-006860-a3b8hyyr	2600	20	-	-	HYPH
cord-006860-a3b8hyyr	2600	21	Ill	Ill	NNP
cord-006860-a3b8hyyr	2600	22	-	-	HYPH
cord-006860-a3b8hyyr	2600	23	Test	test	NN
cord-006860-a3b8hyyr	2600	24	and	and	CC
cord-006860-a3b8hyyr	2600	25	a	a	DT
cord-006860-a3b8hyyr	2600	26	high	high	JJ
cord-006860-a3b8hyyr	2600	27	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	2600	28	level	level	NN
cord-006860-a3b8hyyr	2600	29	were	be	VBD
cord-006860-a3b8hyyr	2600	30	significant	significant	JJ
cord-006860-a3b8hyyr	2600	31	risk	risk	NN
cord-006860-a3b8hyyr	2600	32	factors	factor	NNS
cord-006860-a3b8hyyr	2600	33	for	for	IN
cord-006860-a3b8hyyr	2600	34	new	new	JJ
cord-006860-a3b8hyyr	2600	35	vascular	vascular	JJ
cord-006860-a3b8hyyr	2600	36	occlusions	occlusion	NNS
cord-006860-a3b8hyyr	2600	37	in	in	IN
cord-006860-a3b8hyyr	2600	38	diabetic	diabetic	JJ
cord-006860-a3b8hyyr	2600	39	patients	patient	NNS
cord-006860-a3b8hyyr	2600	40	.	.	.
cord-006860-a3b8hyyr	2601	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	2601	2	was	be	VBD
cord-006860-a3b8hyyr	2601	3	the	the	DT
cord-006860-a3b8hyyr	2601	4	aim	aim	NN
cord-006860-a3b8hyyr	2601	5	of	of	IN
cord-006860-a3b8hyyr	2601	6	the	the	DT
cord-006860-a3b8hyyr	2601	7	HAPARG	HAPARG	NNP
cord-006860-a3b8hyyr	2601	8	study	study	NN
cord-006860-a3b8hyyr	2601	9	to	to	TO
cord-006860-a3b8hyyr	2601	10	establish	establish	VB
cord-006860-a3b8hyyr	2601	11	if	if	IN
cord-006860-a3b8hyyr	2601	12	spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	2601	13	plateletsggregation	plateletsggregation	NN
cord-006860-a3b8hyyr	2601	14	and	and	CC
cord-006860-a3b8hyyr	2601	15	other	other	JJ
cord-006860-a3b8hyyr	2601	16	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	2601	17	variables	variable	NNS
cord-006860-a3b8hyyr	2601	18	are	be	VBP
cord-006860-a3b8hyyr	2601	19	independent	independent	JJ
cord-006860-a3b8hyyr	2601	20	risk	risk	NN
cord-006860-a3b8hyyr	2601	21	factors	factor	NNS
cord-006860-a3b8hyyr	2601	22	for	for	IN
cord-006860-a3b8hyyr	2601	23	vascular	vascular	JJ
cord-006860-a3b8hyyr	2601	24	occlusions	occlusion	NNS
cord-006860-a3b8hyyr	2601	25	also	also	RB
cord-006860-a3b8hyyr	2601	26	in	in	IN
cord-006860-a3b8hyyr	2601	27	healthy	healthy	JJ
cord-006860-a3b8hyyr	2601	28	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	2601	29	.	.	.
cord-006860-a3b8hyyr	2602	1	Employees	employee	NNS
cord-006860-a3b8hyyr	2602	2	of	of	IN
cord-006860-a3b8hyyr	2602	3	HSchst	HSchst	NNP
cord-006860-a3b8hyyr	2602	4	AG	AG	NNP
cord-006860-a3b8hyyr	2602	5	,	,	,
cord-006860-a3b8hyyr	2602	6	Frankfurt	Frankfurt	NNP
cord-006860-a3b8hyyr	2602	7	aged	age	VBD
cord-006860-a3b8hyyr	2602	8	40	40	CD
cord-006860-a3b8hyyr	2602	9	-	-	SYM
cord-006860-a3b8hyyr	2602	10	65	65	CD
cord-006860-a3b8hyyr	2602	11	years	year	NNS
cord-006860-a3b8hyyr	2602	12	and	and	CC
cord-006860-a3b8hyyr	2602	13	personnel	personnel	NNS
cord-006860-a3b8hyyr	2602	14	of	of	IN
cord-006860-a3b8hyyr	2602	15	the	the	DT
cord-006860-a3b8hyyr	2602	16	University	University	NNP
cord-006860-a3b8hyyr	2602	17	of	of	IN
cord-006860-a3b8hyyr	2602	18	Mainz	Mainz	NNP
cord-006860-a3b8hyyr	2602	19	,	,	,
cord-006860-a3b8hyyr	2602	20	aged	aged	JJ
cord-006860-a3b8hyyr	2602	21	30	30	CD
cord-006860-a3b8hyyr	2602	22	-	-	SYM
cord-006860-a3b8hyyr	2602	23	60	60	CD
cord-006860-a3b8hyyr	2602	24	y.	y.	NN
cord-006860-a3b8hyyr	2602	25	entered	enter	VBD
cord-006860-a3b8hyyr	2602	26	this	this	DT
cord-006860-a3b8hyyr	2602	27	prospective	prospective	JJ
cord-006860-a3b8hyyr	2602	28	study	study	NN
cord-006860-a3b8hyyr	2602	29	.	.	.
cord-006860-a3b8hyyr	2603	1	Besides	besides	IN
cord-006860-a3b8hyyr	2603	2	anamnestic	anamnestic	JJ
cord-006860-a3b8hyyr	2603	3	data	datum	NNS
cord-006860-a3b8hyyr	2603	4	on	on	IN
cord-006860-a3b8hyyr	2603	5	smoking	smoking	NN
cord-006860-a3b8hyyr	2603	6	,	,	,
cord-006860-a3b8hyyr	2603	7	hypertension	hypertension	NN
cord-006860-a3b8hyyr	2603	8	and	and	CC
cord-006860-a3b8hyyr	2603	9	diabetes	diabetes	NN
cord-006860-a3b8hyyr	2603	10	blood	blood	NN
cord-006860-a3b8hyyr	2603	11	pressure	pressure	NN
cord-006860-a3b8hyyr	2603	12	,	,	,
cord-006860-a3b8hyyr	2603	13	the	the	DT
cord-006860-a3b8hyyr	2603	14	ankle	ankle	NN
cord-006860-a3b8hyyr	2603	15	/	/	SYM
cord-006860-a3b8hyyr	2603	16	arm	arm	NN
cord-006860-a3b8hyyr	2603	17	Doppler	Doppler	NNP
cord-006860-a3b8hyyr	2603	18	-index	-index	NNP
cord-006860-a3b8hyyr	2603	19	and	and	CC
cord-006860-a3b8hyyr	2603	20	an	an	DT
cord-006860-a3b8hyyr	2603	21	ECG	ECG	NNP
cord-006860-a3b8hyyr	2603	22	were	be	VBD
cord-006860-a3b8hyyr	2603	23	recorded	record	VBN
cord-006860-a3b8hyyr	2603	24	and	and	CC
cord-006860-a3b8hyyr	2603	25	serum	serum	NN
cord-006860-a3b8hyyr	2603	26	cholesterol	cholesterol	NN
cord-006860-a3b8hyyr	2603	27	,	,	,
cord-006860-a3b8hyyr	2603	28	HDL	HDL	NNP
cord-006860-a3b8hyyr	2603	29	,	,	,
cord-006860-a3b8hyyr	2603	30	LDL	LDL	NNP
cord-006860-a3b8hyyr	2603	31	,	,	,
cord-006860-a3b8hyyr	2603	32	triglycerides	triglyceride	NNS
cord-006860-a3b8hyyr	2603	33	,	,	,
cord-006860-a3b8hyyr	2603	34	uric	uric	NN
cord-006860-a3b8hyyr	2603	35	acid	acid	NN
cord-006860-a3b8hyyr	2603	36	and	and	CC
cord-006860-a3b8hyyr	2603	37	glucose	glucose	NN
cord-006860-a3b8hyyr	2603	38	were	be	VBD
cord-006860-a3b8hyyr	2603	39	measured	measure	VBN
cord-006860-a3b8hyyr	2603	40	.	.	.
cord-006860-a3b8hyyr	2604	1	1885	1885	CD
cord-006860-a3b8hyyr	2604	2	men	man	NNS
cord-006860-a3b8hyyr	2604	3	and	and	CC
cord-006860-a3b8hyyr	2604	4	988	988	CD
cord-006860-a3b8hyyr	2604	5	women	woman	NNS
cord-006860-a3b8hyyr	2604	6	entered	enter	VBD
cord-006860-a3b8hyyr	2604	7	the	the	DT
cord-006860-a3b8hyyr	2604	8	study	study	NN
cord-006860-a3b8hyyr	2604	9	and	and	CC
cord-006860-a3b8hyyr	2604	10	were	be	VBD
cord-006860-a3b8hyyr	2604	11	followed	follow	VBN
cord-006860-a3b8hyyr	2604	12	for	for	IN
cord-006860-a3b8hyyr	2604	13	4	4	CD
cord-006860-a3b8hyyr	2604	14	-	-	SYM
cord-006860-a3b8hyyr	2604	15	6	6	CD
cord-006860-a3b8hyyr	2604	16	years	year	NNS
cord-006860-a3b8hyyr	2604	17	.	.	.
cord-006860-a3b8hyyr	2605	1	During	during	IN
cord-006860-a3b8hyyr	2605	2	this	this	DT
cord-006860-a3b8hyyr	2605	3	period	period	NN
cord-006860-a3b8hyyr	2605	4	53	53	CD
cord-006860-a3b8hyyr	2605	5	vascular	vascular	JJ
cord-006860-a3b8hyyr	2605	6	occlusions	occlusion	NNS
cord-006860-a3b8hyyr	2605	7	ocoured	ocoure	VBD
cord-006860-a3b8hyyr	2605	8	(	(	-LRB-
cord-006860-a3b8hyyr	2605	9	36	36	CD
cord-006860-a3b8hyyr	2605	10	coronary	coronary	JJ
cord-006860-a3b8hyyr	2605	11	and	and	CC
cord-006860-a3b8hyyr	2605	12	9	9	CD
cord-006860-a3b8hyyr	2605	13	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	2605	14	events	event	NNS
cord-006860-a3b8hyyr	2605	15	and	and	CC
cord-006860-a3b8hyyr	2605	16	8	8	CD
cord-006860-a3b8hyyr	2605	17	peripheral	peripheral	JJ
cord-006860-a3b8hyyr	2605	18	vascular	vascular	JJ
cord-006860-a3b8hyyr	2605	19	occlusions	occlusion	NNS
cord-006860-a3b8hyyr	2605	20	)	)	-RRB-
cord-006860-a3b8hyyr	2605	21	.	.	.
cord-006860-a3b8hyyr	2606	1	Only	only	RB
cord-006860-a3b8hyyr	2606	2	three	three	CD
cord-006860-a3b8hyyr	2606	3	of	of	IN
cord-006860-a3b8hyyr	2606	4	these	these	DT
cord-006860-a3b8hyyr	2606	5	events	event	NNS
cord-006860-a3b8hyyr	2606	6	occured	occur	VBD
cord-006860-a3b8hyyr	2606	7	in	in	IN
cord-006860-a3b8hyyr	2606	8	women	woman	NNS
cord-006860-a3b8hyyr	2606	9	.	.	.
cord-006860-a3b8hyyr	2607	1	Besides	besides	IN
cord-006860-a3b8hyyr	2607	2	age	age	NN
cord-006860-a3b8hyyr	2607	3	and	and	CC
cord-006860-a3b8hyyr	2607	4	gender	gender	NN
cord-006860-a3b8hyyr	2607	5	as	as	IN
cord-006860-a3b8hyyr	2607	6	expected	expect	VBN
cord-006860-a3b8hyyr	2607	7	risk	risk	NN
cord-006860-a3b8hyyr	2607	8	factors	factor	NNS
cord-006860-a3b8hyyr	2607	9	the	the	DT
cord-006860-a3b8hyyr	2607	10	multivariate	multivariate	JJ
cord-006860-a3b8hyyr	2607	11	logistic	logistic	JJ
cord-006860-a3b8hyyr	2607	12	stepwise	stepwise	JJ
cord-006860-a3b8hyyr	2607	13	regression	regression	NN
cord-006860-a3b8hyyr	2607	14	analysis	analysis	NN
cord-006860-a3b8hyyr	2607	15	revealed	reveal	VBN
cord-006860-a3b8hyyr	2607	16	as	as	IN
cord-006860-a3b8hyyr	2607	17	significant	significant	JJ
cord-006860-a3b8hyyr	2607	18	risk	risk	NN
cord-006860-a3b8hyyr	2607	19	factors	factor	NNS
cord-006860-a3b8hyyr	2607	20	slightly	slightly	RB
cord-006860-a3b8hyyr	2607	21	elevated	elevated	JJ
cord-006860-a3b8hyyr	2607	22	levels	level	NNS
cord-006860-a3b8hyyr	2607	23	of	of	IN
cord-006860-a3b8hyyr	2607	24	blood	blood	NN
cord-006860-a3b8hyyr	2607	25	glucose	glucose	NN
cord-006860-a3b8hyyr	2607	26	(	(	-LRB-
cord-006860-a3b8hyyr	2607	27	p=0.001	p=0.001	NNP
cord-006860-a3b8hyyr	2607	28	)	)	-RRB-
cord-006860-a3b8hyyr	2607	29	,	,	,
cord-006860-a3b8hyyr	2607	30	smoking	smoking	NN
cord-006860-a3b8hyyr	2607	31	(	(	-LRB-
cord-006860-a3b8hyyr	2607	32	p=0.0013	p=0.0013	NNP
cord-006860-a3b8hyyr	2607	33	)	)	-RRB-
cord-006860-a3b8hyyr	2607	34	,	,	,
cord-006860-a3b8hyyr	2607	35	an	an	DT
cord-006860-a3b8hyyr	2607	36	elevated	elevated	JJ
cord-006860-a3b8hyyr	2607	37	diastolic	diastolic	JJ
cord-006860-a3b8hyyr	2607	38	blood	blood	NN
cord-006860-a3b8hyyr	2607	39	pressure	pressure	NN
cord-006860-a3b8hyyr	2607	40	(	(	-LRB-
cord-006860-a3b8hyyr	2607	41	p=0,018),followed	p=0,018),followe	VBN
cord-006860-a3b8hyyr	2607	42	by	by	IN
cord-006860-a3b8hyyr	2607	43	spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	2607	44	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2607	45	(	(	-LRB-
cord-006860-a3b8hyyr	2607	46	p	p	NN
cord-006860-a3b8hyyr	2607	47	=	=	SYM
cord-006860-a3b8hyyr	2607	48	0.017	0.017	CD
cord-006860-a3b8hyyr	2607	49	)	)	-RRB-
cord-006860-a3b8hyyr	2607	50	and	and	CC
cord-006860-a3b8hyyr	2607	51	higher	high	JJR
cord-006860-a3b8hyyr	2607	52	HDL	hdl	NN
cord-006860-a3b8hyyr	2607	53	-	-	HYPH
cord-006860-a3b8hyyr	2607	54	levels	level	NNS
cord-006860-a3b8hyyr	2607	55	(	(	-LRB-
cord-006860-a3b8hyyr	2607	56	p=0.034	p=0.034	RB
cord-006860-a3b8hyyr	2607	57	)	)	-RRB-
cord-006860-a3b8hyyr	2607	58	as	as	IN
cord-006860-a3b8hyyr	2607	59	significant	significant	JJ
cord-006860-a3b8hyyr	2607	60	risk	risk	NN
cord-006860-a3b8hyyr	2607	61	factors	factor	NNS
cord-006860-a3b8hyyr	2607	62	for	for	IN
cord-006860-a3b8hyyr	2607	63	men	man	NNS
cord-006860-a3b8hyyr	2607	64	.	.	.
cord-006860-a3b8hyyr	2608	1	Higher	high	JJR
cord-006860-a3b8hyyr	2608	2	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	2608	3	levels	level	NNS
cord-006860-a3b8hyyr	2608	4	just	just	RB
cord-006860-a3b8hyyr	2608	5	missed	miss	VBD
cord-006860-a3b8hyyr	2608	6	significance	significance	NN
cord-006860-a3b8hyyr	2608	7	in	in	IN
cord-006860-a3b8hyyr	2608	8	this	this	DT
cord-006860-a3b8hyyr	2608	9	analysis	analysis	NN
cord-006860-a3b8hyyr	2608	10	(	(	-LRB-
cord-006860-a3b8hyyr	2608	11	p=0.059	p=0.059	NNP
cord-006860-a3b8hyyr	2608	12	)	)	-RRB-
cord-006860-a3b8hyyr	2608	13	.	.	.
cord-006860-a3b8hyyr	2609	1	None	none	NN
cord-006860-a3b8hyyr	2609	2	of	of	IN
cord-006860-a3b8hyyr	2609	3	the	the	DT
cord-006860-a3b8hyyr	2609	4	other	other	JJ
cord-006860-a3b8hyyr	2609	5	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	2609	6	parameters	parameter	NNS
cord-006860-a3b8hyyr	2609	7	showed	show	VBD
cord-006860-a3b8hyyr	2609	8	any	any	DT
cord-006860-a3b8hyyr	2609	9	significant	significant	JJ
cord-006860-a3b8hyyr	2609	10	correlation	correlation	NN
cord-006860-a3b8hyyr	2609	11	with	with	IN
cord-006860-a3b8hyyr	2609	12	the	the	DT
cord-006860-a3b8hyyr	2609	13	vascular	vascular	JJ
cord-006860-a3b8hyyr	2609	14	events	event	NNS
cord-006860-a3b8hyyr	2609	15	.	.	.
cord-006860-a3b8hyyr	2610	1	To	to	IN
cord-006860-a3b8hyyr	2610	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2610	3	knowledge	knowledge	NN
cord-006860-a3b8hyyr	2610	4	this	this	DT
cord-006860-a3b8hyyr	2610	5	has	have	VBZ
cord-006860-a3b8hyyr	2610	6	been	be	VBN
cord-006860-a3b8hyyr	2610	7	the	the	DT
cord-006860-a3b8hyyr	2610	8	first	first	JJ
cord-006860-a3b8hyyr	2610	9	prospective	prospective	JJ
cord-006860-a3b8hyyr	2610	10	trial	trial	NN
cord-006860-a3b8hyyr	2610	11	in	in	IN
cord-006860-a3b8hyyr	2610	12	a	a	DT
cord-006860-a3b8hyyr	2610	13	large	large	JJ
cord-006860-a3b8hyyr	2610	14	population	population	NN
cord-006860-a3b8hyyr	2610	15	of	of	IN
cord-006860-a3b8hyyr	2610	16	healthy	healthy	JJ
cord-006860-a3b8hyyr	2610	17	individuals	individual	NNS
cord-006860-a3b8hyyr	2610	18	in	in	IN
cord-006860-a3b8hyyr	2610	19	which	which	WDT
cord-006860-a3b8hyyr	2610	20	a	a	DT
cord-006860-a3b8hyyr	2610	21	platelet	platelet	NN
cord-006860-a3b8hyyr	2610	22	function	function	NN
cord-006860-a3b8hyyr	2610	23	parameter	parameter	NN
cord-006860-a3b8hyyr	2610	24	has	have	VBZ
cord-006860-a3b8hyyr	2610	25	been	be	VBN
cord-006860-a3b8hyyr	2610	26	studied	study	VBN
cord-006860-a3b8hyyr	2610	27	together	together	RB
cord-006860-a3b8hyyr	2610	28	with	with	IN
cord-006860-a3b8hyyr	2610	29	other	other	JJ
cord-006860-a3b8hyyr	2610	30	possible	possible	JJ
cord-006860-a3b8hyyr	2610	31	risk	risk	NN
cord-006860-a3b8hyyr	2610	32	factors	factor	NNS
cord-006860-a3b8hyyr	2610	33	.	.	.
cord-006860-a3b8hyyr	2611	1	Spontaneously	spontaneously	RB
cord-006860-a3b8hyyr	2611	2	enhanced	enhanced	JJ
cord-006860-a3b8hyyr	2611	3	platelet	platelet	NN
cord-006860-a3b8hyyr	2611	4	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2611	5	seems	seem	VBZ
cord-006860-a3b8hyyr	2611	6	to	to	TO
cord-006860-a3b8hyyr	2611	7	be	be	VB
cord-006860-a3b8hyyr	2611	8	an	an	DT
cord-006860-a3b8hyyr	2611	9	independent	independent	JJ
cord-006860-a3b8hyyr	2611	10	risk	risk	NN
cord-006860-a3b8hyyr	2611	11	factor	factor	NN
cord-006860-a3b8hyyr	2611	12	and	and	CC
cord-006860-a3b8hyyr	2611	13	may	may	MD
cord-006860-a3b8hyyr	2611	14	be	be	VB
cord-006860-a3b8hyyr	2611	15	an	an	DT
cord-006860-a3b8hyyr	2611	16	indicator	indicator	NN
cord-006860-a3b8hyyr	2611	17	of	of	IN
cord-006860-a3b8hyyr	2611	18	an	an	DT
cord-006860-a3b8hyyr	2611	19	ongoing	ongoing	JJ
cord-006860-a3b8hyyr	2611	20	active	active	JJ
cord-006860-a3b8hyyr	2611	21	atherosclerotic	atherosclerotic	JJ
cord-006860-a3b8hyyr	2611	22	process	process	NN
cord-006860-a3b8hyyr	2611	23	.	.	.
cord-006860-a3b8hyyr	2612	1	Mild	mild	JJ
cord-006860-a3b8hyyr	2612	2	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	2612	3	symptoms	symptom	NNS
cord-006860-a3b8hyyr	2612	4	-petechia	-petechia	.
cord-006860-a3b8hyyr	2613	1	,	,	,
cord-006860-a3b8hyyr	2613	2	prolonged	prolong	VBN
cord-006860-a3b8hyyr	2613	3	bleeding	bleeding	NN
cord-006860-a3b8hyyr	2613	4	after	after	RB
cord-006860-a3b8hyyr	2614	1	tooth	tooth	NN
cord-006860-a3b8hyyr	2614	2	extraction	extraction	NN
cord-006860-a3b8hyyr	2614	3	-were	-were	,
cord-006860-a3b8hyyr	2614	4	observed	observe	VBN
cord-006860-a3b8hyyr	2614	5	in	in	IN
cord-006860-a3b8hyyr	2614	6	a	a	DT
cord-006860-a3b8hyyr	2614	7	patient	patient	NN
cord-006860-a3b8hyyr	2614	8	with	with	IN
cord-006860-a3b8hyyr	2614	9	normal	normal	JJ
cord-006860-a3b8hyyr	2614	10	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2614	11	tests	test	NNS
cord-006860-a3b8hyyr	2614	12	but	but	CC
cord-006860-a3b8hyyr	2614	13	slightly	slightly	RB
cord-006860-a3b8hyyr	2614	14	disturbed	disturbed	JJ
cord-006860-a3b8hyyr	2614	15	phtelet	phtelet	JJ
cord-006860-a3b8hyyr	2614	16	function	function	NN
cord-006860-a3b8hyyr	2614	17	:	:	:
cord-006860-a3b8hyyr	2614	18	decreased	decrease	VBN
cord-006860-a3b8hyyr	2614	19	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2614	20	in	in	IN
cord-006860-a3b8hyyr	2614	21	response	response	NN
cord-006860-a3b8hyyr	2614	22	to	to	IN
cord-006860-a3b8hyyr	2614	23	ADP	ADP	NNP
cord-006860-a3b8hyyr	2614	24	,	,	,
cord-006860-a3b8hyyr	2614	25	PAl	PAl	NNS
cord-006860-a3b8hyyr	2614	26	:	:	:
cord-006860-a3b8hyyr	2614	27	and	and	CC
cord-006860-a3b8hyyr	2614	28	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	2614	29	receptor	receptor	NN
cord-006860-a3b8hyyr	2614	30	-	-	HYPH
cord-006860-a3b8hyyr	2614	31	derived	derive	VBN
cord-006860-a3b8hyyr	2614	32	peptide	peptide	NN
cord-006860-a3b8hyyr	2614	33	(	(	-LRB-
cord-006860-a3b8hyyr	2614	34	TRAP-6	TRAP-6	NNP
cord-006860-a3b8hyyr	2614	35	)	)	-RRB-
cord-006860-a3b8hyyr	2614	36	.	.	.
cord-006860-a3b8hyyr	2615	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	2615	2	count	count	NN
cord-006860-a3b8hyyr	2615	3	,	,	,
cord-006860-a3b8hyyr	2615	4	agglutination	agglutination	NN
cord-006860-a3b8hyyr	2615	5	with	with	IN
cord-006860-a3b8hyyr	2615	6	both	both	CC
cord-006860-a3b8hyyr	2615	7	ristocetin	ristocetin	NN
cord-006860-a3b8hyyr	2615	8	and	and	CC
cord-006860-a3b8hyyr	2615	9	botrocetin	botrocetin	NNS
cord-006860-a3b8hyyr	2615	10	and	and	CC
cord-006860-a3b8hyyr	2615	11	thrombininduced	thrombininduced	JJ
cord-006860-a3b8hyyr	2615	12	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2615	13	were	be	VBD
cord-006860-a3b8hyyr	2615	14	in	in	IN
cord-006860-a3b8hyyr	2615	15	the	the	DT
cord-006860-a3b8hyyr	2615	16	normal	normal	JJ
cord-006860-a3b8hyyr	2615	17	range	range	NN
cord-006860-a3b8hyyr	2615	18	.	.	.
cord-006860-a3b8hyyr	2616	1	An	an	DT
cord-006860-a3b8hyyr	2616	2	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	2616	3	membrane	membrane	NN
cord-006860-a3b8hyyr	2616	4	glycoprotein	glycoprotein	NN
cord-006860-a3b8hyyr	2616	5	detected	detect	VBN
cord-006860-a3b8hyyr	2616	6	in	in	IN
cord-006860-a3b8hyyr	2616	7	electrophoretic	electrophoretic	JJ
cord-006860-a3b8hyyr	2616	8	studies	study	NNS
cord-006860-a3b8hyyr	2616	9	of	of	IN
cord-006860-a3b8hyyr	2616	10	the	the	DT
cord-006860-a3b8hyyr	2616	11	patient	patient	NN
cord-006860-a3b8hyyr	2616	12	's	's	POS
cord-006860-a3b8hyyr	2616	13	platelet	platelet	NN
cord-006860-a3b8hyyr	2616	14	proteins	protein	NNS
cord-006860-a3b8hyyr	2616	15	was	be	VBD
cord-006860-a3b8hyyr	2616	16	shown	show	VBN
cord-006860-a3b8hyyr	2616	17	to	to	TO
cord-006860-a3b8hyyr	2616	18	be	be	VB
cord-006860-a3b8hyyr	2616	19	related	relate	VBN
cord-006860-a3b8hyyr	2616	20	to	to	IN
cord-006860-a3b8hyyr	2616	21	GP	GP	NNP
cord-006860-a3b8hyyr	2616	22	llxx	llxx	NNS
cord-006860-a3b8hyyr	2616	23	by	by	IN
cord-006860-a3b8hyyr	2616	24	immunoblotting	immunoblotte	VBG
cord-006860-a3b8hyyr	2616	25	.	.	.
cord-006860-a3b8hyyr	2617	1	The	the	DT
cord-006860-a3b8hyyr	2617	2	variant	variant	NN
cord-006860-a3b8hyyr	2617	3	GP	gp	NN
cord-006860-a3b8hyyr	2617	4	differed	differ	VBD
cord-006860-a3b8hyyr	2617	5	even	even	RB
cord-006860-a3b8hyyr	2617	6	from	from	IN
cord-006860-a3b8hyyr	2617	7	the	the	DT
cord-006860-a3b8hyyr	2617	8	largest	large	JJS
cord-006860-a3b8hyyr	2617	9	normal	normal	JJ
cord-006860-a3b8hyyr	2617	10	polymorphic	polymorphic	JJ
cord-006860-a3b8hyyr	2617	11	GP	GP	NNP
cord-006860-a3b8hyyr	2617	12	Iba	Iba	NNP
cord-006860-a3b8hyyr	2617	13	form	form	VB
cord-006860-a3b8hyyr	2617	14	A	a	NN
cord-006860-a3b8hyyr	2617	15	by	by	IN
cord-006860-a3b8hyyr	2617	16	an	an	DT
cord-006860-a3b8hyyr	2617	17	increase	increase	NN
cord-006860-a3b8hyyr	2617	18	in	in	IN
cord-006860-a3b8hyyr	2617	19	molecular	molecular	JJ
cord-006860-a3b8hyyr	2617	20	mass	mass	NN
cord-006860-a3b8hyyr	2617	21	,	,	,
cord-006860-a3b8hyyr	2617	22	Platelets	platelet	NNS
cord-006860-a3b8hyyr	2617	23	of	of	IN
cord-006860-a3b8hyyr	2617	24	the	the	DT
cord-006860-a3b8hyyr	2617	25	patient	patient	NN
cord-006860-a3b8hyyr	2617	26	contain	contain	VBP
cord-006860-a3b8hyyr	2617	27	the	the	DT
cord-006860-a3b8hyyr	2617	28	variant	variant	NN
cord-006860-a3b8hyyr	2617	29	and	and	CC
cord-006860-a3b8hyyr	2617	30	normal	normal	JJ
cord-006860-a3b8hyyr	2617	31	C	c	NN
cord-006860-a3b8hyyr	2617	32	form	form	NN
cord-006860-a3b8hyyr	2617	33	in	in	IN
cord-006860-a3b8hyyr	2617	34	equal	equal	JJ
cord-006860-a3b8hyyr	2617	35	amounts	amount	NNS
cord-006860-a3b8hyyr	2617	36	.	.	.
cord-006860-a3b8hyyr	2618	1	The	the	DT
cord-006860-a3b8hyyr	2618	2	quantity	quantity	NN
cord-006860-a3b8hyyr	2618	3	of	of	IN
cord-006860-a3b8hyyr	2618	4	GP	GP	NNP
cord-006860-a3b8hyyr	2618	5	Ib	Ib	NNP
cord-006860-a3b8hyyr	2618	6	as	as	IN
cord-006860-a3b8hyyr	2618	7	detected	detect	VBN
cord-006860-a3b8hyyr	2618	8	by	by	IN
cord-006860-a3b8hyyr	2618	9	flow	flow	NN
cord-006860-a3b8hyyr	2618	10	cytometry	cytometry	NN
cord-006860-a3b8hyyr	2618	11	is	be	VBZ
cord-006860-a3b8hyyr	2618	12	normal	normal	JJ
cord-006860-a3b8hyyr	2618	13	.	.	.
cord-006860-a3b8hyyr	2619	1	lmmunoblotting	lmmunoblotting	NNP
cord-006860-a3b8hyyr	2619	2	studies	study	NNS
cord-006860-a3b8hyyr	2619	3	of	of	IN
cord-006860-a3b8hyyr	2619	4	proteolytic	proteolytic	JJ
cord-006860-a3b8hyyr	2619	5	fragments	fragment	NNS
cord-006860-a3b8hyyr	2619	6	of	of	IN
cord-006860-a3b8hyyr	2619	7	the	the	DT
cord-006860-a3b8hyyr	2619	8	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	2619	9	GP	gp	NN
cord-006860-a3b8hyyr	2619	10	indicated	indicate	VBD
cord-006860-a3b8hyyr	2619	11	that	that	IN
cord-006860-a3b8hyyr	2619	12	the	the	DT
cord-006860-a3b8hyyr	2619	13	defect	defect	NN
cord-006860-a3b8hyyr	2619	14	is	be	VBZ
cord-006860-a3b8hyyr	2619	15	located	locate	VBN
cord-006860-a3b8hyyr	2619	16	in	in	IN
cord-006860-a3b8hyyr	2619	17	the	the	DT
cord-006860-a3b8hyyr	2619	18	C	C	NNP
cord-006860-a3b8hyyr	2619	19	-	-	HYPH
cord-006860-a3b8hyyr	2619	20	terminal	terminal	NN
cord-006860-a3b8hyyr	2619	21	part	part	NN
cord-006860-a3b8hyyr	2619	22	of	of	IN
cord-006860-a3b8hyyr	2619	23	the	the	DT
cord-006860-a3b8hyyr	2619	24	glycocalicin	glycocalicin	NNS
cord-006860-a3b8hyyr	2619	25	fragment	fragment	NN
cord-006860-a3b8hyyr	2619	26	.	.	.
cord-006860-a3b8hyyr	2620	1	Measurement	measurement	NN
cord-006860-a3b8hyyr	2620	2	of	of	IN
cord-006860-a3b8hyyr	2620	3	the	the	DT
cord-006860-a3b8hyyr	2620	4	length	length	NN
cord-006860-a3b8hyyr	2620	5	of	of	IN
cord-006860-a3b8hyyr	2620	6	glycocalicin	glycocalicin	NNS
cord-006860-a3b8hyyr	2620	7	molecules	molecule	NNS
cord-006860-a3b8hyyr	2620	8	after	after	IN
cord-006860-a3b8hyyr	2620	9	glycerol	glycerol	NN
cord-006860-a3b8hyyr	2620	10	-	-	HYPH
cord-006860-a3b8hyyr	2620	11	spraying	spray	VBG
cord-006860-a3b8hyyr	2620	12	rotary	rotary	NN
cord-006860-a3b8hyyr	2620	13	shadowing	shadow	VBG
cord-006860-a3b8hyyr	2620	14	electron	electron	NN
cord-006860-a3b8hyyr	2620	15	microscopy	microscopy	NNS
cord-006860-a3b8hyyr	2620	16	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	2620	17	two	two	CD
cord-006860-a3b8hyyr	2620	18	populations	population	NNS
cord-006860-a3b8hyyr	2620	19	of	of	IN
cord-006860-a3b8hyyr	2620	20	molecules	molecule	NNS
cord-006860-a3b8hyyr	2620	21	in	in	IN
cord-006860-a3b8hyyr	2620	22	the	the	DT
cord-006860-a3b8hyyr	2620	23	patient	patient	JJ
cord-006860-a3b8hyyr	2620	24	sample	sample	NN
cord-006860-a3b8hyyr	2620	25	:	:	:
cord-006860-a3b8hyyr	2620	26	a	a	DT
cord-006860-a3b8hyyr	2620	27	normal	normal	JJ
cord-006860-a3b8hyyr	2620	28	on	on	IN
cord-006860-a3b8hyyr	2620	29	with	with	IN
cord-006860-a3b8hyyr	2620	30	an	an	DT
cord-006860-a3b8hyyr	2620	31	average	average	JJ
cord-006860-a3b8hyyr	2620	32	size	size	NN
cord-006860-a3b8hyyr	2620	33	of	of	IN
cord-006860-a3b8hyyr	2620	34	470	470	CD
cord-006860-a3b8hyyr	2620	35	Angstr6	Angstr6	NNP
cord-006860-a3b8hyyr	2620	36	m	m	NNP
cord-006860-a3b8hyyr	2620	37	and	and	CC
cord-006860-a3b8hyyr	2620	38	a	a	DT
cord-006860-a3b8hyyr	2620	39	fraction	fraction	NN
cord-006860-a3b8hyyr	2620	40	with	with	IN
cord-006860-a3b8hyyr	2620	41	an	an	DT
cord-006860-a3b8hyyr	2620	42	average	average	JJ
cord-006860-a3b8hyyr	2620	43	size	size	NN
cord-006860-a3b8hyyr	2620	44	0f650	0f650	.
cord-006860-a3b8hyyr	2621	1	Angstr6n~	Angstr6n~	NNP
cord-006860-a3b8hyyr	2621	2	Preliminary	preliminary	JJ
cord-006860-a3b8hyyr	2621	3	results	result	NNS
cord-006860-a3b8hyyr	2621	4	of	of	IN
cord-006860-a3b8hyyr	2621	5	molecular	molecular	JJ
cord-006860-a3b8hyyr	2621	6	analysis	analysis	NN
cord-006860-a3b8hyyr	2621	7	of	of	IN
cord-006860-a3b8hyyr	2621	8	the	the	DT
cord-006860-a3b8hyyr	2621	9	GP	GP	NNP
cord-006860-a3b8hyyr	2621	10	Iba	Iba	NNP
cord-006860-a3b8hyyr	2621	11	gene	gene	NN
cord-006860-a3b8hyyr	2621	12	in	in	IN
cord-006860-a3b8hyyr	2621	13	the	the	DT
cord-006860-a3b8hyyr	2621	14	patient	patient	NN
cord-006860-a3b8hyyr	2621	15	confirm	confirm	VBP
cord-006860-a3b8hyyr	2621	16	the	the	DT
cord-006860-a3b8hyyr	2621	17	localization	localization	NN
cord-006860-a3b8hyyr	2621	18	of	of	IN
cord-006860-a3b8hyyr	2621	19	the	the	DT
cord-006860-a3b8hyyr	2621	20	genetic	genetic	JJ
cord-006860-a3b8hyyr	2621	21	defect	defect	NN
cord-006860-a3b8hyyr	2621	22	by	by	IN
cord-006860-a3b8hyyr	2621	23	protein	protein	NN
cord-006860-a3b8hyyr	2621	24	studies	study	NNS
cord-006860-a3b8hyyr	2621	25	.	.	.
cord-006860-a3b8hyyr	2622	1	In	in	IN
cord-006860-a3b8hyyr	2622	2	summary	summary	NN
cord-006860-a3b8hyyr	2622	3	,	,	,
cord-006860-a3b8hyyr	2622	4	the	the	DT
cord-006860-a3b8hyyr	2622	5	patient	patient	NN
cord-006860-a3b8hyyr	2622	6	is	be	VBZ
cord-006860-a3b8hyyr	2622	7	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	2622	8	for	for	IN
cord-006860-a3b8hyyr	2622	9	a	a	DT
cord-006860-a3b8hyyr	2622	10	hitherto	hitherto	RB
cord-006860-a3b8hyyr	2622	11	undescdbed	undescdbed	JJ
cord-006860-a3b8hyyr	2622	12	molecular	molecular	JJ
cord-006860-a3b8hyyr	2622	13	variant	variant	NN
cord-006860-a3b8hyyr	2622	14	ofGP	ofGP	NNP
cord-006860-a3b8hyyr	2623	1	~a	~a	NNS
cord-006860-a3b8hyyr	2623	2	.	.	.
cord-006860-a3b8hyyr	2624	1	Barnes	Barnes	NNP
cord-006860-a3b8hyyr	2624	2	and	and	CC
cord-006860-a3b8hyyr	2624	3	co	co	NNS
cord-006860-a3b8hyyr	2624	4	-	-	NNS
cord-006860-a3b8hyyr	2624	5	workers	worker	NNS
cord-006860-a3b8hyyr	2624	6	have	have	VBP
cord-006860-a3b8hyyr	2624	7	shown	show	VBN
cord-006860-a3b8hyyr	2624	8	that	that	IN
cord-006860-a3b8hyyr	2624	9	simple	simple	JJ
cord-006860-a3b8hyyr	2624	10	triple	triple	JJ
cord-006860-a3b8hyyr	2624	11	-	-	HYPH
cord-006860-a3b8hyyr	2624	12	helical	helical	JJ
cord-006860-a3b8hyyr	2624	13	collagenlike	collagenlike	NN
cord-006860-a3b8hyyr	2624	14	peptides	peptide	NNS
cord-006860-a3b8hyyr	2624	15	,	,	,
cord-006860-a3b8hyyr	2624	16	comprising	comprise	VBG
cord-006860-a3b8hyyr	2624	17	basically	basically	RB
cord-006860-a3b8hyyr	2624	18	a	a	DT
cord-006860-a3b8hyyr	2624	19	repeat	repeat	NN
cord-006860-a3b8hyyr	2624	20	Gly	Gly	NNP
cord-006860-a3b8hyyr	2624	21	-	-	HYPH
cord-006860-a3b8hyyr	2624	22	Pro	pro	JJ
cord-006860-a3b8hyyr	2624	23	-	-	JJ
cord-006860-a3b8hyyr	2624	24	Hyp	hyp	JJ
cord-006860-a3b8hyyr	2624	25	structure	structure	NN
cord-006860-a3b8hyyr	2624	26	,	,	,
cord-006860-a3b8hyyr	2624	27	are	be	VBP
cord-006860-a3b8hyyr	2624	28	highly	highly	RB
cord-006860-a3b8hyyr	2624	29	platelet	platelet	JJ
cord-006860-a3b8hyyr	2624	30	reactive	reactive	JJ
cord-006860-a3b8hyyr	2624	31	in	in	IN
cord-006860-a3b8hyyr	2624	32	polymeric	polymeric	JJ
cord-006860-a3b8hyyr	2624	33	form	form	NN
cord-006860-a3b8hyyr	2624	34	.	.	.
cord-006860-a3b8hyyr	2625	1	They	-PRON-	PRP
cord-006860-a3b8hyyr	2625	2	additionally	additionally	RB
cord-006860-a3b8hyyr	2625	3	have	have	VBP
cord-006860-a3b8hyyr	2625	4	shown	show	VBN
cord-006860-a3b8hyyr	2625	5	that	that	IN
cord-006860-a3b8hyyr	2625	6	the	the	DT
cord-006860-a3b8hyyr	2625	7	activity	activity	NN
cord-006860-a3b8hyyr	2625	8	does	do	VBZ
cord-006860-a3b8hyyr	2625	9	not	not	RB
cord-006860-a3b8hyyr	2625	10	involve	involve	VB
cord-006860-a3b8hyyr	2625	11	GPla	GPla	NNP
cord-006860-a3b8hyyr	2625	12	/	/	SYM
cord-006860-a3b8hyyr	2625	13	lla	lla	NNP
cord-006860-a3b8hyyr	2625	14	(	(	-LRB-
cord-006860-a3b8hyyr	2625	15	integdn	integdn	NNP
cord-006860-a3b8hyyr	2625	16	c	c	NNP
cord-006860-a3b8hyyr	2625	17	~	~	NFP
cord-006860-a3b8hyyr	2625	18	z	z	NNP
cord-006860-a3b8hyyr	2625	19	~	~	NFP
cord-006860-a3b8hyyr	2625	20	l	l	NN
cord-006860-a3b8hyyr	2625	21	)	)	-RRB-
cord-006860-a3b8hyyr	2625	22	.	.	.
cord-006860-a3b8hyyr	2626	1	Platelets	platelet	NNS
cord-006860-a3b8hyyr	2626	2	adhere	adhere	VBP
cord-006860-a3b8hyyr	2626	3	under	under	IN
cord-006860-a3b8hyyr	2626	4	static	static	JJ
cord-006860-a3b8hyyr	2626	5	conditions	condition	NNS
cord-006860-a3b8hyyr	2626	6	to	to	IN
cord-006860-a3b8hyyr	2626	7	these	these	DT
cord-006860-a3b8hyyr	2626	8	fibrillar	fibrillar	NNP
cord-006860-a3b8hyyr	2626	9	peptides	peptide	NNS
cord-006860-a3b8hyyr	2626	10	mainly	mainly	RB
cord-006860-a3b8hyyr	2626	11	in	in	IN
cord-006860-a3b8hyyr	2626	12	a	a	DT
cord-006860-a3b8hyyr	2626	13	bivalent	bivalent	JJ
cord-006860-a3b8hyyr	2626	14	-	-	HYPH
cord-006860-a3b8hyyr	2626	15	cation	cation	NN
cord-006860-a3b8hyyr	2626	16	independent	independent	JJ
cord-006860-a3b8hyyr	2626	17	manner	manner	NN
cord-006860-a3b8hyyr	2626	18	;	;	:
cord-006860-a3b8hyyr	2626	19	the	the	DT
cord-006860-a3b8hyyr	2626	20	bivalent	bivalent	NNP
cord-006860-a3b8hyyr	2626	21	cation	cation	NN
cord-006860-a3b8hyyr	2626	22	dependent	dependent	JJ
cord-006860-a3b8hyyr	2626	23	adhesion	adhesion	NN
cord-006860-a3b8hyyr	2626	24	can	can	MD
cord-006860-a3b8hyyr	2626	25	be	be	VB
cord-006860-a3b8hyyr	2626	26	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	2626	27	by	by	IN
cord-006860-a3b8hyyr	2626	28	an	an	DT
cord-006860-a3b8hyyr	2626	29	antibody	antibody	NN
cord-006860-a3b8hyyr	2626	30	against	against	IN
cord-006860-a3b8hyyr	2626	31	GPflb	GPflb	NNP
cord-006860-a3b8hyyr	2626	32	/	/	SYM
cord-006860-a3b8hyyr	2626	33	llla	llla	NNP
cord-006860-a3b8hyyr	2626	34	(	(	-LRB-
cord-006860-a3b8hyyr	2626	35	integfin	integfin	NNP
cord-006860-a3b8hyyr	2626	36	m	m	NNP
cord-006860-a3b8hyyr	2626	37	~	~	CD
cord-006860-a3b8hyyr	2626	38	d33	d33	NNP
cord-006860-a3b8hyyr	2626	39	)	)	-RRB-
cord-006860-a3b8hyyr	2626	40	.	.	.
cord-006860-a3b8hyyr	2627	1	However	however	RB
cord-006860-a3b8hyyr	2627	2	,	,	,
cord-006860-a3b8hyyr	2627	3	platelets	platelet	NNS
cord-006860-a3b8hyyr	2627	4	of	of	IN
cord-006860-a3b8hyyr	2627	5	a	a	DT
cord-006860-a3b8hyyr	2627	6	patient	patient	NN
cord-006860-a3b8hyyr	2627	7	with	with	IN
cord-006860-a3b8hyyr	2627	8	type	type	NN
cord-006860-a3b8hyyr	2628	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	2628	2	Glanzmann	Glanzmann	NNP
cord-006860-a3b8hyyr	2628	3	's	's	POS
cord-006860-a3b8hyyr	2628	4	thrombasthenia	thrombasthenia	NNP
cord-006860-a3b8hyyr	2628	5	secreted	secrete	VBD
cord-006860-a3b8hyyr	2628	6	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2628	7	¢z	¢z	NNP
cord-006860-a3b8hyyr	2628	8	-	-	HYPH
cord-006860-a3b8hyyr	2628	9	granule	granule	NN
cord-006860-a3b8hyyr	2628	10	-	-	HYPH
cord-006860-a3b8hyyr	2628	11	and	and	CC
cord-006860-a3b8hyyr	2628	12	dense	dense	JJ
cord-006860-a3b8hyyr	2628	13	body	body	NN
cord-006860-a3b8hyyr	2628	14	content	content	NN
cord-006860-a3b8hyyr	2628	15	just	just	RB
cord-006860-a3b8hyyr	2628	16	like	like	IN
cord-006860-a3b8hyyr	2628	17	normal	normal	JJ
cord-006860-a3b8hyyr	2628	18	controls	control	NNS
cord-006860-a3b8hyyr	2628	19	while	while	IN
cord-006860-a3b8hyyr	2628	20	activated	activate	VBN
cord-006860-a3b8hyyr	2628	21	with	with	IN
cord-006860-a3b8hyyr	2628	22	the	the	DT
cord-006860-a3b8hyyr	2628	23	triple	triple	JJ
cord-006860-a3b8hyyr	2628	24	-	-	HYPH
cord-006860-a3b8hyyr	2628	25	helical	helical	JJ
cord-006860-a3b8hyyr	2628	26	Gly	Gly	NNP
cord-006860-a3b8hyyr	2628	27	-	-	HYPH
cord-006860-a3b8hyyr	2628	28	Pro	pro	JJ
cord-006860-a3b8hyyr	2628	29	-	-	JJ
cord-006860-a3b8hyyr	2628	30	Hyp	Hyp	NNP
cord-006860-a3b8hyyr	2628	31	peptide	peptide	NN
cord-006860-a3b8hyyr	2628	32	.	.	.
cord-006860-a3b8hyyr	2629	1	The	the	DT
cord-006860-a3b8hyyr	2629	2	lack	lack	NN
cord-006860-a3b8hyyr	2629	3	of	of	IN
cord-006860-a3b8hyyr	2629	4	an	an	DT
cord-006860-a3b8hyyr	2629	5	essential	essential	JJ
cord-006860-a3b8hyyr	2629	6	involvement	involvement	NN
cord-006860-a3b8hyyr	2629	7	of	of	IN
cord-006860-a3b8hyyr	2629	8	CD36	CD36	NNP
cord-006860-a3b8hyyr	2629	9	was	be	VBD
cord-006860-a3b8hyyr	2629	10	shown	show	VBN
cord-006860-a3b8hyyr	2629	11	with	with	IN
cord-006860-a3b8hyyr	2629	12	CD36deficient	CD36deficient	NNP
cord-006860-a3b8hyyr	2629	13	platelets	platelet	NNS
cord-006860-a3b8hyyr	2629	14	,	,	,
cord-006860-a3b8hyyr	2629	15	which	which	WDT
cord-006860-a3b8hyyr	2629	16	respond	respond	VBP
cord-006860-a3b8hyyr	2629	17	to	to	IN
cord-006860-a3b8hyyr	2629	18	the	the	DT
cord-006860-a3b8hyyr	2629	19	peptides	peptide	NNS
cord-006860-a3b8hyyr	2629	20	as	as	RB
cord-006860-a3b8hyyr	2629	21	readily	readily	RB
cord-006860-a3b8hyyr	2629	22	as	as	IN
cord-006860-a3b8hyyr	2629	23	normal	normal	JJ
cord-006860-a3b8hyyr	2629	24	platelets	platelet	NNS
cord-006860-a3b8hyyr	2629	25	when	when	WRB
cord-006860-a3b8hyyr	2629	26	fibdnogen	fibdnogen	NNP
cord-006860-a3b8hyyr	2629	27	binding	bind	VBG
cord-006860-a3b8hyyr	2629	28	and	and	CC
cord-006860-a3b8hyyr	2629	29	CD62	CD62	NNP
cord-006860-a3b8hyyr	2629	30	and	and	CC
cord-006860-a3b8hyyr	2629	31	CD63	CD63	NNP
cord-006860-a3b8hyyr	2629	32	expression	expression	NN
cord-006860-a3b8hyyr	2629	33	were	be	VBD
cord-006860-a3b8hyyr	2629	34	measured	measure	VBN
cord-006860-a3b8hyyr	2629	35	.	.	.
cord-006860-a3b8hyyr	2630	1	To	to	TO
cord-006860-a3b8hyyr	2630	2	study	study	VB
cord-006860-a3b8hyyr	2630	3	the	the	DT
cord-006860-a3b8hyyr	2630	4	involvement	involvement	NN
cord-006860-a3b8hyyr	2630	5	of	of	IN
cord-006860-a3b8hyyr	2630	6	the	the	DT
cord-006860-a3b8hyyr	2630	7	yon	yon	NNP
cord-006860-a3b8hyyr	2630	8	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	2630	9	factor	factor	NN
cord-006860-a3b8hyyr	2630	10	(	(	-LRB-
cord-006860-a3b8hyyr	2630	11	vWf	vWf	NNS
cord-006860-a3b8hyyr	2630	12	)	)	-RRB-
cord-006860-a3b8hyyr	2630	13	platetets	platetet	NNS
cord-006860-a3b8hyyr	2630	14	from	from	IN
cord-006860-a3b8hyyr	2630	15	a	a	DT
cord-006860-a3b8hyyr	2630	16	patient	patient	NN
cord-006860-a3b8hyyr	2630	17	with	with	IN
cord-006860-a3b8hyyr	2630	18	severe	severe	JJ
cord-006860-a3b8hyyr	2630	19	type	type	NN
cord-006860-a3b8hyyr	2630	20	3	3	CD
cord-006860-a3b8hyyr	2630	21	vWd	vWd	NNS
cord-006860-a3b8hyyr	2630	22	(	(	-LRB-
cord-006860-a3b8hyyr	2630	23	vWf	vWf	NNS
cord-006860-a3b8hyyr	2630	24	not	not	RB
cord-006860-a3b8hyyr	2630	25	detectable	detectable	JJ
cord-006860-a3b8hyyr	2630	26	in	in	IN
cord-006860-a3b8hyyr	2630	27	platelets	platelet	NNS
cord-006860-a3b8hyyr	2630	28	and	and	CC
cord-006860-a3b8hyyr	2630	29	plasma	plasma	NN
cord-006860-a3b8hyyr	2630	30	)	)	-RRB-
cord-006860-a3b8hyyr	2630	31	were	be	VBD
cord-006860-a3b8hyyr	2630	32	investigated	investigate	VBN
cord-006860-a3b8hyyr	2630	33	.	.	.
cord-006860-a3b8hyyr	2631	1	The	the	DT
cord-006860-a3b8hyyr	2631	2	vWf	vWf	NNS
cord-006860-a3b8hyyr	2631	3	deficient	deficient	JJ
cord-006860-a3b8hyyr	2631	4	ptatelets	ptatelet	NNS
cord-006860-a3b8hyyr	2631	5	responded	respond	VBD
cord-006860-a3b8hyyr	2631	6	quite	quite	RB
cord-006860-a3b8hyyr	2631	7	normally	normally	RB
cord-006860-a3b8hyyr	2631	8	to	to	IN
cord-006860-a3b8hyyr	2631	9	the	the	DT
cord-006860-a3b8hyyr	2631	10	fibritlar	fibritlar	JJ
cord-006860-a3b8hyyr	2631	11	collagen	collagen	NN
cord-006860-a3b8hyyr	2631	12	-	-	HYPH
cord-006860-a3b8hyyr	2631	13	like	like	JJ
cord-006860-a3b8hyyr	2631	14	peptide	peptide	NN
cord-006860-a3b8hyyr	2631	15	.	.	.
cord-006860-a3b8hyyr	2632	1	Addition	addition	NN
cord-006860-a3b8hyyr	2632	2	of	of	IN
cord-006860-a3b8hyyr	2632	3	pudfied	pudfie	VBN
cord-006860-a3b8hyyr	2632	4	vWf	vWf	NNS
cord-006860-a3b8hyyr	2632	5	to	to	IN
cord-006860-a3b8hyyr	2632	6	the	the	DT
cord-006860-a3b8hyyr	2632	7	vWf	vWf	NNS
cord-006860-a3b8hyyr	2632	8	-	-	HYPH
cord-006860-a3b8hyyr	2632	9	deficient	deficient	JJ
cord-006860-a3b8hyyr	2632	10	platelets	platelet	NNS
cord-006860-a3b8hyyr	2632	11	before	before	IN
cord-006860-a3b8hyyr	2632	12	adding	add	VBG
cord-006860-a3b8hyyr	2632	13	the	the	DT
cord-006860-a3b8hyyr	2632	14	paptide	paptide	NN
cord-006860-a3b8hyyr	2632	15	raised	raise	VBD
cord-006860-a3b8hyyr	2632	16	the	the	DT
cord-006860-a3b8hyyr	2632	17	platelet	platelet	NN
cord-006860-a3b8hyyr	2632	18	respond	respond	VB
cord-006860-a3b8hyyr	2632	19	slightly	slightly	RB
cord-006860-a3b8hyyr	2633	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2633	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	2633	3	that	that	IN
cord-006860-a3b8hyyr	2633	4	neither	neither	CC
cord-006860-a3b8hyyr	2633	5	~3~	~3~	CD
cord-006860-a3b8hyyr	2633	6	integrin	integrin	NN
cord-006860-a3b8hyyr	2633	7	,	,	,
cord-006860-a3b8hyyr	2633	8	nor	nor	CC
cord-006860-a3b8hyyr	2633	9	m~	m~	XX
cord-006860-a3b8hyyr	2633	10	integdn	integdn	NN
cord-006860-a3b8hyyr	2633	11	,	,	,
cord-006860-a3b8hyyr	2633	12	nor	nor	CC
cord-006860-a3b8hyyr	2633	13	CD36	CD36	NNP
cord-006860-a3b8hyyr	2633	14	,	,	,
cord-006860-a3b8hyyr	2633	15	nor	nor	CC
cord-006860-a3b8hyyr	2633	16	vWf	vWf	NNS
cord-006860-a3b8hyyr	2633	17	are	be	VBP
cord-006860-a3b8hyyr	2633	18	the	the	DT
cord-006860-a3b8hyyr	2633	19	pdmary	pdmary	JJ
cord-006860-a3b8hyyr	2633	20	platelet	platelet	NN
cord-006860-a3b8hyyr	2633	21	receptor	receptor	NN
cord-006860-a3b8hyyr	2633	22	for	for	IN
cord-006860-a3b8hyyr	2633	23	the	the	DT
cord-006860-a3b8hyyr	2633	24	collagen	collagen	NN
cord-006860-a3b8hyyr	2633	25	-	-	HYPH
cord-006860-a3b8hyyr	2633	26	like	like	JJ
cord-006860-a3b8hyyr	2633	27	peptide	peptide	NN
cord-006860-a3b8hyyr	2633	28	.	.	.
cord-006860-a3b8hyyr	2634	1	There	there	EX
cord-006860-a3b8hyyr	2634	2	is	be	VBZ
cord-006860-a3b8hyyr	2634	3	evidence	evidence	NN
cord-006860-a3b8hyyr	2634	4	that	that	IN
cord-006860-a3b8hyyr	2634	5	native	native	JJ
cord-006860-a3b8hyyr	2634	6	low	low	JJ
cord-006860-a3b8hyyr	2634	7	density	density	NN
cord-006860-a3b8hyyr	2634	8	lipoprotein	lipoprotein	NN
cord-006860-a3b8hyyr	2634	9	(	(	-LRB-
cord-006860-a3b8hyyr	2634	10	LDL	LDL	NNP
cord-006860-a3b8hyyr	2634	11	)	)	-RRB-
cord-006860-a3b8hyyr	2634	12	can	can	MD
cord-006860-a3b8hyyr	2634	13	be	be	VB
cord-006860-a3b8hyyr	2634	14	oxidatively	oxidatively	RB
cord-006860-a3b8hyyr	2634	15	modified	modify	VBN
cord-006860-a3b8hyyr	2634	16	in	in	IN
cord-006860-a3b8hyyr	2634	17	vivo	vivo	NN
cord-006860-a3b8hyyr	2634	18	and	and	CC
cord-006860-a3b8hyyr	2634	19	the	the	DT
cord-006860-a3b8hyyr	2634	20	oxidized	oxidize	VBN
cord-006860-a3b8hyyr	2634	21	LDL	LDL	NNP
cord-006860-a3b8hyyr	2634	22	may	may	MD
cord-006860-a3b8hyyr	2634	23	contribute	contribute	VB
cord-006860-a3b8hyyr	2634	24	to	to	IN
cord-006860-a3b8hyyr	2634	25	thrombogenesis	thrombogenesis	NN
cord-006860-a3b8hyyr	2634	26	and	and	CC
cord-006860-a3b8hyyr	2634	27	atherogenesis	atherogenesis	NN
cord-006860-a3b8hyyr	2634	28	by	by	IN
cord-006860-a3b8hyyr	2634	29	damaging	damage	VBG
cord-006860-a3b8hyyr	2634	30	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	2634	31	cells	cell	NNS
cord-006860-a3b8hyyr	2634	32	,	,	,
cord-006860-a3b8hyyr	2634	33	eliciting	elicit	VBG
cord-006860-a3b8hyyr	2634	34	vasocontractiola	vasocontractiola	NNP
cord-006860-a3b8hyyr	2634	35	and	and	CC
cord-006860-a3b8hyyr	2634	36	stimulating	stimulate	VBG
cord-006860-a3b8hyyr	2634	37	blood	blood	NN
cord-006860-a3b8hyyr	2634	38	platelets	platelet	NNS
cord-006860-a3b8hyyr	2634	39	.	.	.
cord-006860-a3b8hyyr	2635	1	By	by	IN
cord-006860-a3b8hyyr	2635	2	means	mean	NNS
cord-006860-a3b8hyyr	2635	3	of	of	IN
cord-006860-a3b8hyyr	2635	4	biochemical	biochemical	JJ
cord-006860-a3b8hyyr	2635	5	methods	method	NNS
cord-006860-a3b8hyyr	2635	6	,	,	,
cord-006860-a3b8hyyr	2635	7	electron	electron	NN
cord-006860-a3b8hyyr	2635	8	microscopy	microscopy	NN
cord-006860-a3b8hyyr	2635	9	,	,	,
cord-006860-a3b8hyyr	2635	10	reflection	reflection	NN
cord-006860-a3b8hyyr	2635	11	contrast	contrast	NN
cord-006860-a3b8hyyr	2635	12	microscopy	microscopy	NNS
cord-006860-a3b8hyyr	2635	13	and	and	CC
cord-006860-a3b8hyyr	2635	14	computer	computer	NN
cord-006860-a3b8hyyr	2635	15	image	image	NN
cord-006860-a3b8hyyr	2635	16	analysis	analysis	NN
cord-006860-a3b8hyyr	2635	17	,	,	,
cord-006860-a3b8hyyr	2635	18	we	-PRON-	PRP
cord-006860-a3b8hyyr	2635	19	find	find	VBP
cord-006860-a3b8hyyr	2635	20	that	that	IN
cord-006860-a3b8hyyr	2635	21	oxidized	oxidize	VBN
cord-006860-a3b8hyyr	2635	22	LDL	ldl	NN
cord-006860-a3b8hyyr	2635	23	,	,	,
cord-006860-a3b8hyyr	2635	24	compared	compare	VBN
cord-006860-a3b8hyyr	2635	25	to	to	IN
cord-006860-a3b8hyyr	2635	26	native	native	JJ
cord-006860-a3b8hyyr	2635	27	LDL	ldl	NN
cord-006860-a3b8hyyr	2635	28	,	,	,
cord-006860-a3b8hyyr	2635	29	affects	affect	VBZ
cord-006860-a3b8hyyr	2635	30	platelets	platelet	NNS
cord-006860-a3b8hyyr	2635	31	at	at	IN
cord-006860-a3b8hyyr	2635	32	least	least	JJS
cord-006860-a3b8hyyr	2635	33	in	in	IN
cord-006860-a3b8hyyr	2635	34	the	the	DT
cord-006860-a3b8hyyr	2635	35	following	following	JJ
cord-006860-a3b8hyyr	2635	36	five	five	CD
cord-006860-a3b8hyyr	2635	37	aspects	aspect	NNS
cord-006860-a3b8hyyr	2635	38	.	.	.
cord-006860-a3b8hyyr	2636	1	1	1	LS
cord-006860-a3b8hyyr	2636	2	)	)	-RRB-
cord-006860-a3b8hyyr	2637	1	Oxidized	oxidize	VBN
cord-006860-a3b8hyyr	2637	2	LDL	ldl	NN
cord-006860-a3b8hyyr	2637	3	alters	alter	VBZ
cord-006860-a3b8hyyr	2637	4	platelet	platelet	NN
cord-006860-a3b8hyyr	2637	5	functional	functional	JJ
cord-006860-a3b8hyyr	2637	6	morphology	morphology	NN
cord-006860-a3b8hyyr	2637	7	in	in	IN
cord-006860-a3b8hyyr	2637	8	a	a	DT
cord-006860-a3b8hyyr	2637	9	time	time	NN
cord-006860-a3b8hyyr	2637	10	and	and	CC
cord-006860-a3b8hyyr	2637	11	dose	dose	NN
cord-006860-a3b8hyyr	2637	12	dependent	dependent	JJ
cord-006860-a3b8hyyr	2637	13	manner	manner	NN
cord-006860-a3b8hyyr	2637	14	.	.	.
cord-006860-a3b8hyyr	2638	1	2	2	LS
cord-006860-a3b8hyyr	2638	2	)	)	-RRB-
cord-006860-a3b8hyyr	2639	1	Oxidized	oxidize	VBN
cord-006860-a3b8hyyr	2639	2	LDL	ldl	NN
cord-006860-a3b8hyyr	2639	3	induces	induce	VBZ
cord-006860-a3b8hyyr	2639	4	secretion	secretion	NN
cord-006860-a3b8hyyr	2639	5	of	of	IN
cord-006860-a3b8hyyr	2639	6	serotonin	serotonin	NN
cord-006860-a3b8hyyr	2639	7	from	from	IN
cord-006860-a3b8hyyr	2639	8	both	both	DT
cord-006860-a3b8hyyr	2639	9	morphological	morphological	JJ
cord-006860-a3b8hyyr	2639	10	resting	rest	VBG
cord-006860-a3b8hyyr	2639	11	platelets	platelet	NNS
cord-006860-a3b8hyyr	2639	12	and	and	CC
cord-006860-a3b8hyyr	2639	13	shape	shape	NN
cord-006860-a3b8hyyr	2639	14	changed	change	VBD
cord-006860-a3b8hyyr	2639	15	platelets	platelet	NNS
cord-006860-a3b8hyyr	2639	16	.	.	.
cord-006860-a3b8hyyr	2640	1	3	3	LS
cord-006860-a3b8hyyr	2640	2	)	)	-RRB-
cord-006860-a3b8hyyr	2641	1	Oxidized	oxidize	VBN
cord-006860-a3b8hyyr	2641	2	LDL	LDL	NNP
cord-006860-a3b8hyyr	2641	3	advances	advance	NNS
cord-006860-a3b8hyyr	2641	4	,	,	,
cord-006860-a3b8hyyr	2641	5	accelerates	accelerate	VBZ
cord-006860-a3b8hyyr	2641	6	and	and	CC
cord-006860-a3b8hyyr	2641	7	enlarges	enlarge	VBZ
cord-006860-a3b8hyyr	2641	8	platelet	platelet	NN
cord-006860-a3b8hyyr	2641	9	adhesion	adhesion	NN
cord-006860-a3b8hyyr	2641	10	.	.	.
cord-006860-a3b8hyyr	2642	1	4	4	LS
cord-006860-a3b8hyyr	2642	2	)	)	-RRB-
cord-006860-a3b8hyyr	2643	1	Oxidized	oxidize	VBN
cord-006860-a3b8hyyr	2643	2	LDL	ldl	NN
cord-006860-a3b8hyyr	2643	3	causes	cause	VBZ
cord-006860-a3b8hyyr	2643	4	cytodamage	cytodamage	NN
cord-006860-a3b8hyyr	2643	5	in	in	IN
cord-006860-a3b8hyyr	2643	6	platelets	platelet	NNS
cord-006860-a3b8hyyr	2643	7	and	and	CC
cord-006860-a3b8hyyr	2643	8	cultured	cultured	JJ
cord-006860-a3b8hyyr	2643	9	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	2643	10	cells	cell	NNS
cord-006860-a3b8hyyr	2643	11	.	.	.
cord-006860-a3b8hyyr	2644	1	5	5	LS
cord-006860-a3b8hyyr	2644	2	)	)	-RRB-
cord-006860-a3b8hyyr	2645	1	Oxidized	oxidize	VBN
cord-006860-a3b8hyyr	2645	2	LDL	ldl	NN
cord-006860-a3b8hyyr	2645	3	stimulates	stimulate	VBZ
cord-006860-a3b8hyyr	2645	4	platelets	platelet	NNS
cord-006860-a3b8hyyr	2645	5	and	and	CC
cord-006860-a3b8hyyr	2645	6	endothelium	endothelium	NN
cord-006860-a3b8hyyr	2645	7	,	,	,
cord-006860-a3b8hyyr	2645	8	which	which	WDT
cord-006860-a3b8hyyr	2645	9	leads	lead	VBZ
cord-006860-a3b8hyyr	2645	10	to	to	IN
cord-006860-a3b8hyyr	2645	11	a	a	DT
cord-006860-a3b8hyyr	2645	12	formation	formation	NN
cord-006860-a3b8hyyr	2645	13	of	of	IN
cord-006860-a3b8hyyr	2645	14	microthrombi	microthrombi	NN
cord-006860-a3b8hyyr	2645	15	on	on	IN
cord-006860-a3b8hyyr	2645	16	the	the	DT
cord-006860-a3b8hyyr	2645	17	monolayer	monolayer	NN
cord-006860-a3b8hyyr	2645	18	of	of	IN
cord-006860-a3b8hyyr	2645	19	human	human	JJ
cord-006860-a3b8hyyr	2645	20	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	2645	21	vein	vein	NN
cord-006860-a3b8hyyr	2645	22	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	2645	23	cells	cell	NNS
cord-006860-a3b8hyyr	2645	24	.	.	.
cord-006860-a3b8hyyr	2646	1	Further	further	JJ
cord-006860-a3b8hyyr	2646	2	experiments	experiment	NNS
cord-006860-a3b8hyyr	2646	3	show	show	VBP
cord-006860-a3b8hyyr	2646	4	that	that	IN
cord-006860-a3b8hyyr	2646	5	oxidized	oxidize	VBN
cord-006860-a3b8hyyr	2646	6	LDL	ldl	NN
cord-006860-a3b8hyyr	2646	7	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	2646	8	the	the	DT
cord-006860-a3b8hyyr	2646	9	activity	activity	NN
cord-006860-a3b8hyyr	2646	10	of	of	IN
cord-006860-a3b8hyyr	2646	11	Ca2	ca2	CD
cord-006860-a3b8hyyr	2646	12	+	+	CC
cord-006860-a3b8hyyr	2647	1	-ATPase	-atpase	IN
cord-006860-a3b8hyyr	2647	2	in	in	IN
cord-006860-a3b8hyyr	2647	3	purified	purify	VBN
cord-006860-a3b8hyyr	2647	4	plasma	plasma	NN
cord-006860-a3b8hyyr	2647	5	membranes	membrane	NNS
cord-006860-a3b8hyyr	2647	6	of	of	IN
cord-006860-a3b8hyyr	2647	7	platelets	platelet	NNS
cord-006860-a3b8hyyr	2647	8	,	,	,
cord-006860-a3b8hyyr	2647	9	and	and	CC
cord-006860-a3b8hyyr	2647	10	therefore	therefore	RB
cord-006860-a3b8hyyr	2647	11	increases	increase	VBZ
cord-006860-a3b8hyyr	2647	12	the	the	DT
cord-006860-a3b8hyyr	2647	13	cytosolic	cytosolic	JJ
cord-006860-a3b8hyyr	2647	14	calcium	calcium	NN
cord-006860-a3b8hyyr	2647	15	level	level	NN
cord-006860-a3b8hyyr	2647	16	in	in	IN
cord-006860-a3b8hyyr	2647	17	platelets	platelet	NNS
cord-006860-a3b8hyyr	2647	18	.	.	.
cord-006860-a3b8hyyr	2648	1	These	these	DT
cord-006860-a3b8hyyr	2648	2	results	result	NNS
cord-006860-a3b8hyyr	2648	3	clearly	clearly	RB
cord-006860-a3b8hyyr	2648	4	indicate	indicate	VBP
cord-006860-a3b8hyyr	2648	5	that	that	IN
cord-006860-a3b8hyyr	2648	6	calcium	calcium	NN
cord-006860-a3b8hyyr	2648	7	signaling	signal	VBG
cord-006860-a3b8hyyr	2648	8	pathway	pathway	NN
cord-006860-a3b8hyyr	2648	9	is	be	VBZ
cord-006860-a3b8hyyr	2648	10	intimately	intimately	RB
cord-006860-a3b8hyyr	2648	11	involved	involved	JJ
cord-006860-a3b8hyyr	2648	12	in	in	IN
cord-006860-a3b8hyyr	2648	13	the	the	DT
cord-006860-a3b8hyyr	2648	14	mechanism	mechanism	NN
cord-006860-a3b8hyyr	2648	15	of	of	IN
cord-006860-a3b8hyyr	2648	16	platelet	platelet	NN
cord-006860-a3b8hyyr	2648	17	activation	activation	NN
cord-006860-a3b8hyyr	2648	18	induced	induce	VBN
cord-006860-a3b8hyyr	2648	19	by	by	IN
cord-006860-a3b8hyyr	2648	20	oxidized	oxidize	VBN
cord-006860-a3b8hyyr	2648	21	LDL	ldl	NN
cord-006860-a3b8hyyr	2648	22	.	.	.
cord-006860-a3b8hyyr	2649	1	Since	since	IN
cord-006860-a3b8hyyr	2649	2	oxidized	oxidized	JJ
cord-006860-a3b8hyyr	2649	3	LDL	ldl	NN
cord-006860-a3b8hyyr	2649	4	,	,	,
cord-006860-a3b8hyyr	2649	5	a	a	DT
cord-006860-a3b8hyyr	2649	6	relevant	relevant	JJ
cord-006860-a3b8hyyr	2649	7	platelet	platelet	NN
cord-006860-a3b8hyyr	2649	8	agonist	agonist	NN
cord-006860-a3b8hyyr	2649	9	,	,	,
cord-006860-a3b8hyyr	2649	10	has	have	VBZ
cord-006860-a3b8hyyr	2649	11	been	be	VBN
cord-006860-a3b8hyyr	2649	12	confirmed	confirm	VBN
cord-006860-a3b8hyyr	2649	13	to	to	TO
cord-006860-a3b8hyyr	2649	14	be	be	VB
cord-006860-a3b8hyyr	2649	15	present	present	JJ
cord-006860-a3b8hyyr	2649	16	in	in	IN
cord-006860-a3b8hyyr	2649	17	vivo	vivo	NN
cord-006860-a3b8hyyr	2649	18	,	,	,
cord-006860-a3b8hyyr	2649	19	further	further	JJ
cord-006860-a3b8hyyr	2649	20	studies	study	NNS
cord-006860-a3b8hyyr	2649	21	on	on	IN
cord-006860-a3b8hyyr	2649	22	its	-PRON-	PRP$
cord-006860-a3b8hyyr	2649	23	role	role	NN
cord-006860-a3b8hyyr	2649	24	in	in	IN
cord-006860-a3b8hyyr	2649	25	platelet	platelet	NN
cord-006860-a3b8hyyr	2649	26	activation	activation	NN
cord-006860-a3b8hyyr	2649	27	and	and	CC
cord-006860-a3b8hyyr	2649	28	plateletendothelium	plateletendothelium	NN
cord-006860-a3b8hyyr	2649	29	-	-	HYPH
cord-006860-a3b8hyyr	2649	30	interaction	interaction	NN
cord-006860-a3b8hyyr	2649	31	can	can	MD
cord-006860-a3b8hyyr	2649	32	help	help	VB
cord-006860-a3b8hyyr	2649	33	for	for	IN
cord-006860-a3b8hyyr	2649	34	better	well	JJR
cord-006860-a3b8hyyr	2649	35	understanding	understand	VBG
cord-006860-a3b8hyyr	2649	36	thrombogenesis	thrombogenesis	NN
cord-006860-a3b8hyyr	2649	37	and	and	CC
cord-006860-a3b8hyyr	2649	38	atherogenesis	atherogenesis	NNP
cord-006860-a3b8hyyr	2649	39	.	.	.
cord-006860-a3b8hyyr	2650	1	Recantly	recantly	IN
cord-006860-a3b8hyyr	2650	2	physical	physical	JJ
cord-006860-a3b8hyyr	2650	3	parameters	parameter	NNS
cord-006860-a3b8hyyr	2650	4	such	such	JJ
cord-006860-a3b8hyyr	2650	5	as	as	IN
cord-006860-a3b8hyyr	2650	6	sheer	sheer	JJ
cord-006860-a3b8hyyr	2650	7	stress	stress	NN
cord-006860-a3b8hyyr	2650	8	,	,	,
cord-006860-a3b8hyyr	2650	9	hypo	hypo	NN
cord-006860-a3b8hyyr	2650	10	-	-	:
cord-006860-a3b8hyyr	2650	11	or	or	CC
cord-006860-a3b8hyyr	2650	12	byperoxic	byperoxic	JJ
cord-006860-a3b8hyyr	2650	13	conditions	condition	NNS
cord-006860-a3b8hyyr	2650	14	and	and	CC
cord-006860-a3b8hyyr	2650	15	hyperthermia	hyperthermia	NN
cord-006860-a3b8hyyr	2650	16	have	have	VBP
cord-006860-a3b8hyyr	2650	17	been	be	VBN
cord-006860-a3b8hyyr	2650	18	shown	show	VBN
cord-006860-a3b8hyyr	2650	19	to	to	TO
cord-006860-a3b8hyyr	2650	20	modulate	modulate	VB
cord-006860-a3b8hyyr	2650	21	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	2650	22	cell	cell	NN
cord-006860-a3b8hyyr	2650	23	dependent	dependent	JJ
cord-006860-a3b8hyyr	2650	24	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	2650	25	.	.	.
cord-006860-a3b8hyyr	2651	1	In	in	IN
cord-006860-a3b8hyyr	2651	2	this	this	DT
cord-006860-a3b8hyyr	2651	3	study	study	NN
cord-006860-a3b8hyyr	2651	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	2651	5	investigated	investigate	VBD
cord-006860-a3b8hyyr	2651	6	whether	whether	IN
cord-006860-a3b8hyyr	2651	7	yet	yet	RB
cord-006860-a3b8hyyr	2651	8	another	another	DT
cord-006860-a3b8hyyr	2651	9	physie~	physie~	NNP
cord-006860-a3b8hyyr	2651	10	stimulus	stimulus	NN
cord-006860-a3b8hyyr	2651	11	namely	namely	RB
cord-006860-a3b8hyyr	2651	12	hypothermia	hypothermia	NN
cord-006860-a3b8hyyr	2651	13	might	may	MD
cord-006860-a3b8hyyr	2651	14	have	have	VB
cord-006860-a3b8hyyr	2651	15	an	an	DT
cord-006860-a3b8hyyr	2651	16	impact	impact	NN
cord-006860-a3b8hyyr	2651	17	on	on	IN
cord-006860-a3b8hyyr	2651	18	the	the	DT
cord-006860-a3b8hyyr	2651	19	expression	expression	NN
cord-006860-a3b8hyyr	2651	20	of	of	IN
cord-006860-a3b8hyyr	2651	21	components	component	NNS
cord-006860-a3b8hyyr	2651	22	of	of	IN
cord-006860-a3b8hyyr	2651	23	the	the	DT
cord-006860-a3b8hyyr	2651	24	fibdnolytic	fibdnolytic	JJ
cord-006860-a3b8hyyr	2651	25	system	system	NN
cord-006860-a3b8hyyr	2651	26	of	of	IN
cord-006860-a3b8hyyr	2651	27	human	human	JJ
cord-006860-a3b8hyyr	2651	28	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	2651	29	cells	cell	NNS
cord-006860-a3b8hyyr	2651	30	in	in	IN
cord-006860-a3b8hyyr	2651	31	culture	culture	NN
cord-006860-a3b8hyyr	2651	32	.	.	.
cord-006860-a3b8hyyr	2652	1	Confluent	confluent	NN
cord-006860-a3b8hyyr	2652	2	cultures	culture	NNS
cord-006860-a3b8hyyr	2652	3	of	of	IN
cord-006860-a3b8hyyr	2652	4	human	human	JJ
cord-006860-a3b8hyyr	2652	5	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	2652	6	vein	vein	NN
cord-006860-a3b8hyyr	2652	7	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	2652	8	cells	cell	NNS
cord-006860-a3b8hyyr	2652	9	(	(	-LRB-
cord-006860-a3b8hyyr	2652	10	HLIVECs	hlivec	NNS
cord-006860-a3b8hyyr	2652	11	)	)	-RRB-
cord-006860-a3b8hyyr	2652	12	were	be	VBD
cord-006860-a3b8hyyr	2652	13	exposed	expose	VBN
cord-006860-a3b8hyyr	2652	14	to	to	IN
cord-006860-a3b8hyyr	2652	15	gC	gC	NNP
cord-006860-a3b8hyyr	2652	16	°	°	NN
cord-006860-a3b8hyyr	2652	17	for	for	IN
cord-006860-a3b8hyyr	2652	18	10	10	CD
cord-006860-a3b8hyyr	2652	19	,	,	,
cord-006860-a3b8hyyr	2652	20	20	20	CD
cord-006860-a3b8hyyr	2652	21	,	,	,
cord-006860-a3b8hyyr	2652	22	40	40	CD
cord-006860-a3b8hyyr	2652	23	,	,	,
cord-006860-a3b8hyyr	2652	24	80	80	CD
cord-006860-a3b8hyyr	2652	25	,	,	,
cord-006860-a3b8hyyr	2652	26	or	or	CC
cord-006860-a3b8hyyr	2652	27	160	160	CD
cord-006860-a3b8hyyr	2652	28	rain	rain	NN
cord-006860-a3b8hyyr	2652	29	,	,	,
cord-006860-a3b8hyyr	2652	30	respectively	respectively	RB
cord-006860-a3b8hyyr	2652	31	.	.	.
cord-006860-a3b8hyyr	2653	1	Control	control	NN
cord-006860-a3b8hyyr	2653	2	cultures	culture	NNS
cord-006860-a3b8hyyr	2653	3	were	be	VBD
cord-006860-a3b8hyyr	2653	4	exposed	expose	VBN
cord-006860-a3b8hyyr	2653	5	to	to	IN
cord-006860-a3b8hyyr	2653	6	37	37	CD
cord-006860-a3b8hyyr	2653	7	°	°	NN
cord-006860-a3b8hyyr	2653	8	C	c	NN
cord-006860-a3b8hyyr	2653	9	for	for	IN
cord-006860-a3b8hyyr	2653	10	the	the	DT
cord-006860-a3b8hyyr	2653	11	same	same	JJ
cord-006860-a3b8hyyr	2653	12	time	time	NN
cord-006860-a3b8hyyr	2653	13	periods	period	NNS
cord-006860-a3b8hyyr	2653	14	.	.	.
cord-006860-a3b8hyyr	2654	1	Thereafter	thereafter	IN
cord-006860-a3b8hyyr	2654	2	medium	medium	NN
cord-006860-a3b8hyyr	2654	3	was	be	VBD
cord-006860-a3b8hyyr	2654	4	removed	remove	VBN
cord-006860-a3b8hyyr	2654	5	,	,	,
cord-006860-a3b8hyyr	2654	6	fresh	fresh	JJ
cord-006860-a3b8hyyr	2654	7	medium	medium	NN
cord-006860-a3b8hyyr	2654	8	was	be	VBD
cord-006860-a3b8hyyr	2654	9	added	add	VBN
cord-006860-a3b8hyyr	2654	10	and	and	CC
cord-006860-a3b8hyyr	2654	11	the	the	DT
cord-006860-a3b8hyyr	2654	12	cells	cell	NNS
cord-006860-a3b8hyyr	2654	13	were	be	VBD
cord-006860-a3b8hyyr	2654	14	incubated	incubate	VBN
cord-006860-a3b8hyyr	2654	15	for	for	IN
cord-006860-a3b8hyyr	2654	16	24	24	CD
cord-006860-a3b8hyyr	2654	17	hours	hour	NNS
cord-006860-a3b8hyyr	2654	18	at	at	IN
cord-006860-a3b8hyyr	2654	19	37	37	CD
cord-006860-a3b8hyyr	2654	20	°	°	NN
cord-006860-a3b8hyyr	2654	21	C	c	NN
cord-006860-a3b8hyyr	2654	22	Conditioned	condition	VBN
cord-006860-a3b8hyyr	2654	23	media	medium	NNS
cord-006860-a3b8hyyr	2654	24	(	(	-LRB-
cord-006860-a3b8hyyr	2654	25	CM	CM	NNP
cord-006860-a3b8hyyr	2654	26	)	)	-RRB-
cord-006860-a3b8hyyr	2654	27	were	be	VBD
cord-006860-a3b8hyyr	2654	28	harvested	harvest	VBN
cord-006860-a3b8hyyr	2654	29	and	and	CC
cord-006860-a3b8hyyr	2654	30	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	2654	31	activator	activator	NN
cord-006860-a3b8hyyr	2654	32	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2654	33	-	-	:
cord-006860-a3b8hyyr	2654	34	I	i	NN
cord-006860-a3b8hyyr	2654	35	(	(	-LRB-
cord-006860-a3b8hyyr	2654	36	PAl	pal	NN
cord-006860-a3b8hyyr	2654	37	-	-	:
cord-006860-a3b8hyyr	2654	38	I	i	NN
cord-006860-a3b8hyyr	2654	39	)	)	-RRB-
cord-006860-a3b8hyyr	2654	40	antigen	antigen	NN
cord-006860-a3b8hyyr	2654	41	was	be	VBD
cord-006860-a3b8hyyr	2654	42	determined	determine	VBN
cord-006860-a3b8hyyr	2654	43	by	by	IN
cord-006860-a3b8hyyr	2654	44	a	a	DT
cord-006860-a3b8hyyr	2654	45	specific	specific	JJ
cord-006860-a3b8hyyr	2654	46	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	2654	47	.	.	.
cord-006860-a3b8hyyr	2655	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	2655	2	data	datum	NNS
cord-006860-a3b8hyyr	2655	3	showed	show	VBD
cord-006860-a3b8hyyr	2655	4	that	that	IN
cord-006860-a3b8hyyr	2655	5	HUVECs	huvec	NNS
cord-006860-a3b8hyyr	2655	6	responded	respond	VBD
cord-006860-a3b8hyyr	2655	7	to	to	IN
cord-006860-a3b8hyyr	2655	8	exposure	exposure	NN
cord-006860-a3b8hyyr	2655	9	to	to	IN
cord-006860-a3b8hyyr	2655	10	8	8	CD
cord-006860-a3b8hyyr	2655	11	°	°	NN
cord-006860-a3b8hyyr	2655	12	C	c	NN
cord-006860-a3b8hyyr	2655	13	with	with	IN
cord-006860-a3b8hyyr	2655	14	a	a	DT
cord-006860-a3b8hyyr	2655	15	time	time	NN
cord-006860-a3b8hyyr	2655	16	-	-	HYPH
cord-006860-a3b8hyyr	2655	17	dependent	dependent	JJ
cord-006860-a3b8hyyr	2655	18	increase	increase	NN
cord-006860-a3b8hyyr	2655	19	of	of	IN
cord-006860-a3b8hyyr	2655	20	PAI	PAI	NNP
cord-006860-a3b8hyyr	2655	21	-	-	HYPH
cord-006860-a3b8hyyr	2655	22	i	i	PRP
cord-006860-a3b8hyyr	2655	23	in	in	IN
cord-006860-a3b8hyyr	2655	24	CM	CM	NNP
cord-006860-a3b8hyyr	2655	25	.	.	.
cord-006860-a3b8hyyr	2656	1	Maximum	maximum	JJ
cord-006860-a3b8hyyr	2656	2	induction	induction	NN
cord-006860-a3b8hyyr	2656	3	of	of	IN
cord-006860-a3b8hyyr	2656	4	PAl-	PAl-	NNP
cord-006860-a3b8hyyr	2656	5	!	!	.
cord-006860-a3b8hyyr	2657	1	antigen	antigen	NNP
cord-006860-a3b8hyyr	2657	2	was	be	VBD
cord-006860-a3b8hyyr	2657	3	seen	see	VBN
cord-006860-a3b8hyyr	2657	4	after	after	IN
cord-006860-a3b8hyyr	2657	5	20	20	CD
cord-006860-a3b8hyyr	2657	6	minutes	minute	NNS
cord-006860-a3b8hyyr	2657	7	exposure	exposure	NN
cord-006860-a3b8hyyr	2657	8	to	to	IN
cord-006860-a3b8hyyr	2658	1	8	8	CD
cord-006860-a3b8hyyr	2658	2	°	°	NN
cord-006860-a3b8hyyr	2658	3	C	C	NNP
cord-006860-a3b8hyyr	2658	4	(	(	-LRB-
cord-006860-a3b8hyyr	2658	5	PAl-	PAl-	NNP
cord-006860-a3b8hyyr	2658	6	!	!	.
cord-006860-a3b8hyyr	2658	7	antigen	antigen	NNP
cord-006860-a3b8hyyr	2658	8	:	:	:
cord-006860-a3b8hyyr	2659	1	754_+.83	754_+.83	CD
cord-006860-a3b8hyyr	2659	2	ng/105	ng/105	NNP
cord-006860-a3b8hyyr	2659	3	cells	cell	NNS
cord-006860-a3b8hyyr	2659	4	for	for	IN
cord-006860-a3b8hyyr	2659	5	treated	treated	JJ
cord-006860-a3b8hyyr	2659	6	cells	cell	NNS
cord-006860-a3b8hyyr	2659	7	;	;	:
cord-006860-a3b8hyyr	2659	8	4202_17	4202_17	CD
cord-006860-a3b8hyyr	2659	9	ng/105	ng/105	NNP
cord-006860-a3b8hyyr	2659	10	cells	cell	NNS
cord-006860-a3b8hyyr	2659	11	for	for	IN
cord-006860-a3b8hyyr	2659	12	control	control	NN
cord-006860-a3b8hyyr	2659	13	cells	cell	NNS
cord-006860-a3b8hyyr	2659	14	)	)	-RRB-
cord-006860-a3b8hyyr	2659	15	.	.	.
cord-006860-a3b8hyyr	2660	1	The	the	DT
cord-006860-a3b8hyyr	2660	2	inereese	inereese	NN
cord-006860-a3b8hyyr	2660	3	in	in	IN
cord-006860-a3b8hyyr	2660	4	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	2660	5	antigen	antigen	NN
cord-006860-a3b8hyyr	2660	6	was	be	VBD
cord-006860-a3b8hyyr	2660	7	also	also	RB
cord-006860-a3b8hyyr	2660	8	reflected	reflect	VBN
cord-006860-a3b8hyyr	2660	9	on	on	IN
cord-006860-a3b8hyyr	2660	10	the	the	DT
cord-006860-a3b8hyyr	2660	11	level	level	NN
cord-006860-a3b8hyyr	2660	12	of	of	IN
cord-006860-a3b8hyyr	2660	13	specific	specific	JJ
cord-006860-a3b8hyyr	2660	14	mRNA	mrna	NN
cord-006860-a3b8hyyr	2660	15	synthesis	synthesis	NN
cord-006860-a3b8hyyr	2660	16	as	as	IN
cord-006860-a3b8hyyr	2660	17	evidenced	evidence	VBN
cord-006860-a3b8hyyr	2660	18	by	by	IN
cord-006860-a3b8hyyr	2660	19	Northern	northern	JJ
cord-006860-a3b8hyyr	2660	20	blotting	blotting	NN
cord-006860-a3b8hyyr	2660	21	which	which	WDT
cord-006860-a3b8hyyr	2660	22	showed	show	VBD
cord-006860-a3b8hyyr	2660	23	a	a	DT
cord-006860-a3b8hyyr	2660	24	twofold	twofold	JJ
cord-006860-a3b8hyyr	2660	25	increase	increase	NN
cord-006860-a3b8hyyr	2660	26	in	in	IN
cord-006860-a3b8hyyr	2660	27	PAI	PAI	NNP
cord-006860-a3b8hyyr	2660	28	-	-	HYPH
cord-006860-a3b8hyyr	2660	29	I	I	NNP
cord-006860-a3b8hyyr	2660	30	specific	specific	JJ
cord-006860-a3b8hyyr	2660	31	mRNA	mrna	NN
cord-006860-a3b8hyyr	2660	32	in	in	IN
cord-006860-a3b8hyyr	2660	33	HUVECs	huvec	NNS
cord-006860-a3b8hyyr	2660	34	exposed	expose	VBN
cord-006860-a3b8hyyr	2660	35	to	to	IN
cord-006860-a3b8hyyr	2660	36	8	8	CD
cord-006860-a3b8hyyr	2660	37	°	°	NN
cord-006860-a3b8hyyr	2660	38	C	c	NN
cord-006860-a3b8hyyr	2660	39	as	as	IN
cord-006860-a3b8hyyr	2660	40	compared	compare	VBN
cord-006860-a3b8hyyr	2660	41	to	to	IN
cord-006860-a3b8hyyr	2660	42	control	control	NN
cord-006860-a3b8hyyr	2660	43	cells	cell	NNS
cord-006860-a3b8hyyr	2660	44	.	.	.
cord-006860-a3b8hyyr	2661	1	In	in	IN
cord-006860-a3b8hyyr	2661	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	2661	3	,	,	,
cord-006860-a3b8hyyr	2661	4	our	-PRON-	PRP$
cord-006860-a3b8hyyr	2661	5	data	data	NN
cord-006860-a3b8hyyr	2661	6	gives	give	VBZ
cord-006860-a3b8hyyr	2661	7	evidence	evidence	NN
cord-006860-a3b8hyyr	2661	8	that	that	IN
cord-006860-a3b8hyyr	2661	9	hypothermic	hypothermic	JJ
cord-006860-a3b8hyyr	2661	10	stress	stress	NN
cord-006860-a3b8hyyr	2661	11	like	like	IN
cord-006860-a3b8hyyr	2661	12	several	several	JJ
cord-006860-a3b8hyyr	2661	13	other	other	JJ
cord-006860-a3b8hyyr	2661	14	forms	form	NNS
cord-006860-a3b8hyyr	2661	15	of	of	IN
cord-006860-a3b8hyyr	2661	16	physiological	physiological	JJ
cord-006860-a3b8hyyr	2661	17	or	or	CC
cord-006860-a3b8hyyr	2661	18	pathological	pathological	JJ
cord-006860-a3b8hyyr	2661	19	stress	stress	NN
cord-006860-a3b8hyyr	2661	20	,	,	,
cord-006860-a3b8hyyr	2661	21	results	result	NNS
cord-006860-a3b8hyyr	2661	22	in	in	IN
cord-006860-a3b8hyyr	2661	23	activation	activation	NN
cord-006860-a3b8hyyr	2661	24	of	of	IN
cord-006860-a3b8hyyr	2661	25	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	2661	26	ceils	ceil	NNS
cord-006860-a3b8hyyr	2661	27	as	as	IN
cord-006860-a3b8hyyr	2661	28	evidenced	evidence	VBN
cord-006860-a3b8hyyr	2661	29	by	by	IN
cord-006860-a3b8hyyr	2661	30	an	an	DT
cord-006860-a3b8hyyr	2661	31	increased	increase	VBN
cord-006860-a3b8hyyr	2661	32	expression	expression	NN
cord-006860-a3b8hyyr	2661	33	of	of	IN
cord-006860-a3b8hyyr	2661	34	PAI	PAI	NNP
cord-006860-a3b8hyyr	2661	35	-	-	HYPH
cord-006860-a3b8hyyr	2661	36	I.	I.	NNP
cord-006860-a3b8hyyr	2662	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	2662	2	findings	finding	NNS
cord-006860-a3b8hyyr	2662	3	provide	provide	VBP
cord-006860-a3b8hyyr	2662	4	~rther	~rther	DT
cord-006860-a3b8hyyr	2662	5	evidence	evidence	NN
cord-006860-a3b8hyyr	2662	6	that	that	IN
cord-006860-a3b8hyyr	2662	7	such	such	JJ
cord-006860-a3b8hyyr	2662	8	activation	activation	NN
cord-006860-a3b8hyyr	2662	9	of	of	IN
cord-006860-a3b8hyyr	2662	10	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	2662	11	cells	cell	NNS
cord-006860-a3b8hyyr	2662	12	can	can	MD
cord-006860-a3b8hyyr	2662	13	be	be	VB
cord-006860-a3b8hyyr	2662	14	induced	induce	VBN
cord-006860-a3b8hyyr	2662	15	not	not	RB
cord-006860-a3b8hyyr	2662	16	only	only	RB
cord-006860-a3b8hyyr	2662	17	by	by	IN
cord-006860-a3b8hyyr	2662	18	biochemical	biochemical	JJ
cord-006860-a3b8hyyr	2662	19	mediators	mediator	NNS
cord-006860-a3b8hyyr	2662	20	but	but	CC
cord-006860-a3b8hyyr	2662	21	also	also	RB
cord-006860-a3b8hyyr	2662	22	by	by	IN
cord-006860-a3b8hyyr	2662	23	physical	physical	JJ
cord-006860-a3b8hyyr	2662	24	stimuli	stimulus	NNS
cord-006860-a3b8hyyr	2662	25	.	.	.
cord-006860-a3b8hyyr	2663	1	Nitric	nitric	NN
cord-006860-a3b8hyyr	2663	2	oxide	oxide	NN
cord-006860-a3b8hyyr	2663	3	(	(	-LRB-
cord-006860-a3b8hyyr	2663	4	NO	no	UH
cord-006860-a3b8hyyr	2663	5	)	)	-RRB-
cord-006860-a3b8hyyr	2663	6	is	be	VBZ
cord-006860-a3b8hyyr	2663	7	formed	form	VBN
cord-006860-a3b8hyyr	2663	8	from	from	IN
cord-006860-a3b8hyyr	2663	9	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	2663	10	L	l	NN
cord-006860-a3b8hyyr	2663	11	-	-	HYPH
cord-006860-a3b8hyyr	2663	12	arginine	arginine	NN
cord-006860-a3b8hyyr	2663	13	by	by	IN
cord-006860-a3b8hyyr	2663	14	two	two	CD
cord-006860-a3b8hyyr	2663	15	NO	no	DT
cord-006860-a3b8hyyr	2663	16	synthase	synthase	NN
cord-006860-a3b8hyyr	2663	17	(	(	-LRB-
cord-006860-a3b8hyyr	2663	18	NOS	NOS	NNP
cord-006860-a3b8hyyr	2663	19	)	)	-RRB-
cord-006860-a3b8hyyr	2663	20	isoforms	isoform	NNS
cord-006860-a3b8hyyr	2663	21	:	:	:
cord-006860-a3b8hyyr	2663	22	a	a	DT
cord-006860-a3b8hyyr	2663	23	Ca+	Ca+	NNP
cord-006860-a3b8hyyr	2663	24	+	+	SYM
cord-006860-a3b8hyyr	2663	25	-dependent	-dependent	JJ
cord-006860-a3b8hyyr	2663	26	constitutive	constitutive	JJ
cord-006860-a3b8hyyr	2663	27	form	form	NN
cord-006860-a3b8hyyr	2663	28	(	(	-LRB-
cord-006860-a3b8hyyr	2663	29	cNOS	cNOS	NNP
cord-006860-a3b8hyyr	2663	30	)	)	-RRB-
cord-006860-a3b8hyyr	2663	31	and	and	CC
cord-006860-a3b8hyyr	2663	32	a	a	DT
cord-006860-a3b8hyyr	2663	33	Ca+÷-independent	ca+÷-independent	NN
cord-006860-a3b8hyyr	2663	34	inducible	inducible	JJ
cord-006860-a3b8hyyr	2663	35	form	form	NN
cord-006860-a3b8hyyr	2663	36	(	(	-LRB-
cord-006860-a3b8hyyr	2663	37	iNOS	inos	NN
cord-006860-a3b8hyyr	2663	38	)	)	-RRB-
cord-006860-a3b8hyyr	2663	39	which	which	WDT
cord-006860-a3b8hyyr	2663	40	is	be	VBZ
cord-006860-a3b8hyyr	2663	41	expressed	express	VBN
cord-006860-a3b8hyyr	2663	42	after	after	IN
cord-006860-a3b8hyyr	2663	43	challenge	challenge	NN
cord-006860-a3b8hyyr	2663	44	of	of	IN
cord-006860-a3b8hyyr	2663	45	cells	cell	NNS
cord-006860-a3b8hyyr	2663	46	with	with	IN
cord-006860-a3b8hyyr	2663	47	immunologic	immunologic	JJ
cord-006860-a3b8hyyr	2663	48	or	or	CC
cord-006860-a3b8hyyr	2663	49	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	2663	50	stimuli	stimulus	NNS
cord-006860-a3b8hyyr	2663	51	.	.	.
cord-006860-a3b8hyyr	2664	1	Endothelial	endothelial	JJ
cord-006860-a3b8hyyr	2664	2	cell	cell	NN
cord-006860-a3b8hyyr	2664	3	derived	derive	VBN
cord-006860-a3b8hyyr	2664	4	NO	no	NN
cord-006860-a3b8hyyr	2664	5	is	be	VBZ
cord-006860-a3b8hyyr	2664	6	an	an	DT
cord-006860-a3b8hyyr	2664	7	important	important	JJ
cord-006860-a3b8hyyr	2664	8	signaling	signaling	NN
cord-006860-a3b8hyyr	2664	9	molecule	molecule	NN
cord-006860-a3b8hyyr	2664	10	inducing	induce	VBG
cord-006860-a3b8hyyr	2664	11	smooth	smooth	JJ
cord-006860-a3b8hyyr	2664	12	muscle	muscle	NN
cord-006860-a3b8hyyr	2664	13	cell	cell	NN
cord-006860-a3b8hyyr	2664	14	relaxation	relaxation	NN
cord-006860-a3b8hyyr	2664	15	and	and	CC
cord-006860-a3b8hyyr	2664	16	platelet	platelet	NN
cord-006860-a3b8hyyr	2664	17	inhibition	inhibition	NN
cord-006860-a3b8hyyr	2664	18	,	,	,
cord-006860-a3b8hyyr	2664	19	however	however	RB
cord-006860-a3b8hyyr	2664	20	its	-PRON-	PRP$
cord-006860-a3b8hyyr	2664	21	role	role	NN
cord-006860-a3b8hyyr	2664	22	in	in	IN
cord-006860-a3b8hyyr	2664	23	cell	cell	NN
cord-006860-a3b8hyyr	2664	24	proliferation	proliferation	NN
cord-006860-a3b8hyyr	2664	25	is	be	VBZ
cord-006860-a3b8hyyr	2664	26	poorly	poorly	RB
cord-006860-a3b8hyyr	2664	27	understood	understand	VBN
cord-006860-a3b8hyyr	2664	28	.	.	.
cord-006860-a3b8hyyr	2665	1	The	the	DT
cord-006860-a3b8hyyr	2665	2	present	present	JJ
cord-006860-a3b8hyyr	2665	3	study	study	NN
cord-006860-a3b8hyyr	2665	4	investigates	investigate	VBZ
cord-006860-a3b8hyyr	2665	5	the	the	DT
cord-006860-a3b8hyyr	2665	6	pattern	pattern	NN
cord-006860-a3b8hyyr	2665	7	of	of	IN
cord-006860-a3b8hyyr	2665	8	NOS	NOS	NNP
cord-006860-a3b8hyyr	2665	9	isoforms	isoform	NNS
cord-006860-a3b8hyyr	2665	10	and	and	CC
cord-006860-a3b8hyyr	2665	11	NO	no	DT
cord-006860-a3b8hyyr	2665	12	production	production	NN
cord-006860-a3b8hyyr	2665	13	in	in	IN
cord-006860-a3b8hyyr	2665	14	actively	actively	RB
cord-006860-a3b8hyyr	2665	15	proliferating	proliferate	VBG
cord-006860-a3b8hyyr	2665	16	low	low	JJ
cord-006860-a3b8hyyr	2665	17	density	density	NN
cord-006860-a3b8hyyr	2665	18	human	human	JJ
cord-006860-a3b8hyyr	2665	19	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	2665	20	vein	vein	NN
cord-006860-a3b8hyyr	2665	21	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	2665	22	cells	cell	NNS
cord-006860-a3b8hyyr	2665	23	(	(	-LRB-
cord-006860-a3b8hyyr	2665	24	LD	LD	NNP
cord-006860-a3b8hyyr	2665	25	-	-	HYPH
cord-006860-a3b8hyyr	2665	26	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2665	27	)	)	-RRB-
cord-006860-a3b8hyyr	2665	28	and	and	CC
cord-006860-a3b8hyyr	2665	29	in	in	IN
cord-006860-a3b8hyyr	2665	30	high	high	JJ
cord-006860-a3b8hyyr	2665	31	density	density	NN
cord-006860-a3b8hyyr	2665	32	monolayers	monolayer	NNS
cord-006860-a3b8hyyr	2665	33	of	of	IN
cord-006860-a3b8hyyr	2665	34	quiescent	quiescent	JJ
cord-006860-a3b8hyyr	2665	35	cells	cell	NNS
cord-006860-a3b8hyyr	2665	36	(	(	-LRB-
cord-006860-a3b8hyyr	2665	37	HD	hd	NN
cord-006860-a3b8hyyr	2665	38	-	-	HYPH
cord-006860-a3b8hyyr	2665	39	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2665	40	)	)	-RRB-
cord-006860-a3b8hyyr	2665	41	.	.	.
cord-006860-a3b8hyyr	2666	1	LD	LD	NNP
cord-006860-a3b8hyyr	2666	2	-	-	HYPH
cord-006860-a3b8hyyr	2666	3	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2666	4	but	but	CC
cord-006860-a3b8hyyr	2666	5	not	not	RB
cord-006860-a3b8hyyr	2666	6	HD	hd	NN
cord-006860-a3b8hyyr	2666	7	-	-	HYPH
cord-006860-a3b8hyyr	2666	8	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2666	9	expressed	express	VBD
cord-006860-a3b8hyyr	2666	10	iNOS	inos	JJ
cord-006860-a3b8hyyr	2666	11	(	(	-LRB-
cord-006860-a3b8hyyr	2666	12	measured	measure	VBN
cord-006860-a3b8hyyr	2666	13	as	as	IN
cord-006860-a3b8hyyr	2666	14	Ca	Ca	NNP
cord-006860-a3b8hyyr	2666	15	+	+	CC
cord-006860-a3b8hyyr	2666	16	+	+	``
cord-006860-a3b8hyyr	2666	17	independent	independent	JJ
cord-006860-a3b8hyyr	2666	18	citrulline	citrulline	NN
cord-006860-a3b8hyyr	2666	19	formation	formation	NN
cord-006860-a3b8hyyr	2666	20	from	from	IN
cord-006860-a3b8hyyr	2666	21	L	l	NN
cord-006860-a3b8hyyr	2666	22	-	-	HYPH
cord-006860-a3b8hyyr	2666	23	arginine	arginine	NN
cord-006860-a3b8hyyr	2666	24	in	in	IN
cord-006860-a3b8hyyr	2666	25	cell	cell	NN
cord-006860-a3b8hyyr	2666	26	lysates	lysate	NNS
cord-006860-a3b8hyyr	2666	27	)	)	-RRB-
cord-006860-a3b8hyyr	2666	28	with	with	IN
cord-006860-a3b8hyyr	2666	29	a	a	DT
cord-006860-a3b8hyyr	2666	30	maximal	maximal	JJ
cord-006860-a3b8hyyr	2666	31	activity	activity	NN
cord-006860-a3b8hyyr	2666	32	of	of	IN
cord-006860-a3b8hyyr	2666	33	30	30	CD
cord-006860-a3b8hyyr	2666	34	-	-	SYM
cord-006860-a3b8hyyr	2666	35	40	40	CD
cord-006860-a3b8hyyr	2666	36	pmoles	pmole	NNS
cord-006860-a3b8hyyr	2666	37	/	/	SYM
cord-006860-a3b8hyyr	2666	38	min	min	NNP
cord-006860-a3b8hyyr	2666	39	/	/	SYM
cord-006860-a3b8hyyr	2666	40	mg	mg	NNP
cord-006860-a3b8hyyr	2666	41	protein	protein	NN
cord-006860-a3b8hyyr	2666	42	,	,	,
cord-006860-a3b8hyyr	2667	1	cNOS	cNOS	NNP
cord-006860-a3b8hyyr	2667	2	(	(	-LRB-
cord-006860-a3b8hyyr	2667	3	Ca	Ca	NNP
cord-006860-a3b8hyyr	2667	4	+	+	CC
cord-006860-a3b8hyyr	2667	5	÷dependent	÷dependent	CD
cord-006860-a3b8hyyr	2667	6	citrulline	citrulline	NN
cord-006860-a3b8hyyr	2667	7	formation	formation	NN
cord-006860-a3b8hyyr	2667	8	)	)	-RRB-
cord-006860-a3b8hyyr	2667	9	was	be	VBD
cord-006860-a3b8hyyr	2667	10	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	2667	11	in	in	IN
cord-006860-a3b8hyyr	2667	12	HD	HD	NNP
cord-006860-a3b8hyyr	2667	13	-	-	HYPH
cord-006860-a3b8hyyr	2667	14	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2667	15	(	(	-LRB-
cord-006860-a3b8hyyr	2667	16	0.02	0.02	CD
cord-006860-a3b8hyyr	2667	17	-	-	SYM
cord-006860-a3b8hyyr	2667	18	0.2	0.2	CD
cord-006860-a3b8hyyr	2667	19	pmoles	pmole	NNS
cord-006860-a3b8hyyr	2667	20	/	/	SYM
cord-006860-a3b8hyyr	2667	21	min	min	NNP
cord-006860-a3b8hyyr	2667	22	/	/	SYM
cord-006860-a3b8hyyr	2667	23	mg	mg	NNP
cord-006860-a3b8hyyr	2667	24	)	)	-RRB-
cord-006860-a3b8hyyr	2667	25	but	but	CC
cord-006860-a3b8hyyr	2667	26	not	not	RB
cord-006860-a3b8hyyr	2667	27	measurable	measurable	JJ
cord-006860-a3b8hyyr	2667	28	in	in	IN
cord-006860-a3b8hyyr	2667	29	LD	LD	NNP
cord-006860-a3b8hyyr	2667	30	-	-	HYPH
cord-006860-a3b8hyyr	2667	31	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2667	32	lysates	lysate	NNS
cord-006860-a3b8hyyr	2667	33	.	.	.
cord-006860-a3b8hyyr	2668	1	lmmunoprecipitation	lmmunoprecipitation	NN
cord-006860-a3b8hyyr	2668	2	of	of	IN
cord-006860-a3b8hyyr	2668	3	cell	cell	NN
cord-006860-a3b8hyyr	2668	4	lysate	lysate	NN
cord-006860-a3b8hyyr	2668	5	with	with	IN
cord-006860-a3b8hyyr	2668	6	a	a	DT
cord-006860-a3b8hyyr	2668	7	mAb	mab	NN
cord-006860-a3b8hyyr	2668	8	against	against	IN
cord-006860-a3b8hyyr	2668	9	murine	murine	JJ
cord-006860-a3b8hyyr	2668	10	macrophage	macrophage	NN
cord-006860-a3b8hyyr	2668	11	iNOS	inos	NN
cord-006860-a3b8hyyr	2668	12	decreased	decrease	VBD
cord-006860-a3b8hyyr	2668	13	iNOS	inos	JJ
cord-006860-a3b8hyyr	2668	14	activity	activity	NN
cord-006860-a3b8hyyr	2668	15	of	of	IN
cord-006860-a3b8hyyr	2668	16	supernatant	supernatant	VBN
cord-006860-a3b8hyyr	2668	17	by	by	IN
cord-006860-a3b8hyyr	2668	18	70	70	CD
cord-006860-a3b8hyyr	2668	19	%	%	NN
cord-006860-a3b8hyyr	2668	20	in	in	IN
cord-006860-a3b8hyyr	2668	21	LD	LD	NNP
cord-006860-a3b8hyyr	2668	22	-	-	HYPH
cord-006860-a3b8hyyr	2668	23	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2668	24	.	.	.
cord-006860-a3b8hyyr	2669	1	Immunoprecipitation	immunoprecipitation	NN
cord-006860-a3b8hyyr	2669	2	with	with	IN
cord-006860-a3b8hyyr	2669	3	an	an	DT
cord-006860-a3b8hyyr	2669	4	anti	anti	NN
cord-006860-a3b8hyyr	2669	5	-	-	JJ
cord-006860-a3b8hyyr	2669	6	ecNOS	ecnos	JJ
cord-006860-a3b8hyyr	2669	7	mAb	mAb	NNS
cord-006860-a3b8hyyr	2669	8	did	do	VBD
cord-006860-a3b8hyyr	2669	9	not	not	RB
cord-006860-a3b8hyyr	2669	10	modify	modify	VB
cord-006860-a3b8hyyr	2669	11	iNOS	inos	JJ
cord-006860-a3b8hyyr	2669	12	activity	activity	NN
cord-006860-a3b8hyyr	2669	13	in	in	IN
cord-006860-a3b8hyyr	2669	14	LD	LD	NNP
cord-006860-a3b8hyyr	2669	15	-	-	HYPH
cord-006860-a3b8hyyr	2669	16	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2669	17	but	but	CC
cord-006860-a3b8hyyr	2669	18	abolished	abolish	VBD
cord-006860-a3b8hyyr	2669	19	cNOS	cnos	DT
cord-006860-a3b8hyyr	2669	20	activity	activity	NN
cord-006860-a3b8hyyr	2669	21	in	in	IN
cord-006860-a3b8hyyr	2669	22	HD	hd	NN
cord-006860-a3b8hyyr	2669	23	-	-	HYPH
cord-006860-a3b8hyyr	2669	24	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2669	25	.	.	.
cord-006860-a3b8hyyr	2670	1	NO	no	DT
cord-006860-a3b8hyyr	2670	2	release	release	NN
cord-006860-a3b8hyyr	2670	3	(	(	-LRB-
cord-006860-a3b8hyyr	2670	4	measured	measure	VBN
cord-006860-a3b8hyyr	2670	5	as	as	IN
cord-006860-a3b8hyyr	2670	6	nitrite	nitrite	NN
cord-006860-a3b8hyyr	2670	7	+	+	CC
cord-006860-a3b8hyyr	2670	8	nitrate	nitrate	NN
cord-006860-a3b8hyyr	2670	9	production	production	NN
cord-006860-a3b8hyyr	2670	10	in	in	IN
cord-006860-a3b8hyyr	2670	11	an	an	DT
cord-006860-a3b8hyyr	2670	12	18	18	CD
cord-006860-a3b8hyyr	2670	13	h	h	NN
cord-006860-a3b8hyyr	2670	14	incubation	incubation	NN
cord-006860-a3b8hyyr	2670	15	in	in	IN
cord-006860-a3b8hyyr	2670	16	the	the	DT
cord-006860-a3b8hyyr	2670	17	presence	presence	NN
cord-006860-a3b8hyyr	2670	18	of	of	IN
cord-006860-a3b8hyyr	2670	19	1	1	CD
cord-006860-a3b8hyyr	2670	20	mM	mm	CD
cord-006860-a3b8hyyr	2670	21	L	l	NN
cord-006860-a3b8hyyr	2670	22	-	-	HYPH
cord-006860-a3b8hyyr	2670	23	arginine	arginine	NN
cord-006860-a3b8hyyr	2670	24	)	)	-RRB-
cord-006860-a3b8hyyr	2670	25	was	be	VBD
cord-006860-a3b8hyyr	2670	26	1.9	1.9	CD
cord-006860-a3b8hyyr	2670	27	nmol	nmol	JJ
cord-006860-a3b8hyyr	2670	28	/	/	SYM
cord-006860-a3b8hyyr	2670	29	mg	mg	NNP
cord-006860-a3b8hyyr	2670	30	cell	cell	NN
cord-006860-a3b8hyyr	2670	31	protein	protein	NN
cord-006860-a3b8hyyr	2670	32	in	in	IN
cord-006860-a3b8hyyr	2670	33	the	the	DT
cord-006860-a3b8hyyr	2670	34	supernatant	supernatant	NN
cord-006860-a3b8hyyr	2670	35	of	of	IN
cord-006860-a3b8hyyr	2670	36	HD	hd	NN
cord-006860-a3b8hyyr	2670	37	-	-	HYPH
cord-006860-a3b8hyyr	2670	38	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2670	39	whereas	whereas	IN
cord-006860-a3b8hyyr	2670	40	it	-PRON-	PRP
cord-006860-a3b8hyyr	2670	41	was	be	VBD
cord-006860-a3b8hyyr	2670	42	t0fold	t0fold	RB
cord-006860-a3b8hyyr	2670	43	higher	high	JJR
cord-006860-a3b8hyyr	2670	44	with	with	IN
cord-006860-a3b8hyyr	2670	45	LD	LD	NNP
cord-006860-a3b8hyyr	2670	46	-	-	HYPH
cord-006860-a3b8hyyr	2670	47	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2670	48	.	.	.
cord-006860-a3b8hyyr	2671	1	Measurement	measurement	NN
cord-006860-a3b8hyyr	2671	2	of	of	IN
cord-006860-a3b8hyyr	2671	3	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	2671	4	cGMP	cgmp	NN
cord-006860-a3b8hyyr	2671	5	after	after	IN
cord-006860-a3b8hyyr	2671	6	stimulation	stimulation	NN
cord-006860-a3b8hyyr	2671	7	of	of	IN
cord-006860-a3b8hyyr	2671	8	cells	cell	NNS
cord-006860-a3b8hyyr	2671	9	with	with	IN
cord-006860-a3b8hyyr	2671	10	I-2	I-2	NNP
cord-006860-a3b8hyyr	2671	11	#	#	NN
cord-006860-a3b8hyyr	2671	12	M	M	NNP
cord-006860-a3b8hyyr	2671	13	ionomycin	ionomycin	NNP
cord-006860-a3b8hyyr	2671	14	(	(	-LRB-
cord-006860-a3b8hyyr	2671	15	a	a	DT
cord-006860-a3b8hyyr	2671	16	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	2671	17	index	index	NN
cord-006860-a3b8hyyr	2671	18	of	of	IN
cord-006860-a3b8hyyr	2671	19	eNOS	enos	JJ
cord-006860-a3b8hyyr	2671	20	activity	activity	NN
cord-006860-a3b8hyyr	2671	21	)	)	-RRB-
cord-006860-a3b8hyyr	2671	22	showed	show	VBD
cord-006860-a3b8hyyr	2671	23	a	a	DT
cord-006860-a3b8hyyr	2671	24	400	400	CD
cord-006860-a3b8hyyr	2671	25	-	-	SYM
cord-006860-a3b8hyyr	2671	26	800	800	CD
cord-006860-a3b8hyyr	2671	27	%	%	NN
cord-006860-a3b8hyyr	2671	28	increase	increase	NN
cord-006860-a3b8hyyr	2671	29	of	of	IN
cord-006860-a3b8hyyr	2671	30	basal	basal	NN
cord-006860-a3b8hyyr	2671	31	levels	level	NNS
cord-006860-a3b8hyyr	2671	32	in	in	IN
cord-006860-a3b8hyyr	2671	33	HD	hd	NN
cord-006860-a3b8hyyr	2671	34	-	-	HYPH
cord-006860-a3b8hyyr	2671	35	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2671	36	but	but	CC
cord-006860-a3b8hyyr	2671	37	only	only	RB
cord-006860-a3b8hyyr	2671	38	50	50	CD
cord-006860-a3b8hyyr	2671	39	-	-	SYM
cord-006860-a3b8hyyr	2671	40	150	150	CD
cord-006860-a3b8hyyr	2671	41	%	%	NN
cord-006860-a3b8hyyr	2671	42	increase	increase	NN
cord-006860-a3b8hyyr	2671	43	in	in	IN
cord-006860-a3b8hyyr	2671	44	LD	LD	NNP
cord-006860-a3b8hyyr	2671	45	-	-	HYPH
cord-006860-a3b8hyyr	2671	46	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2671	47	.	.	.
cord-006860-a3b8hyyr	2672	1	On	on	IN
cord-006860-a3b8hyyr	2672	2	the	the	DT
cord-006860-a3b8hyyr	2672	3	contrary	contrary	NN
cord-006860-a3b8hyyr	2672	4	,	,	,
cord-006860-a3b8hyyr	2672	5	sodium	sodium	NN
cord-006860-a3b8hyyr	2672	6	nitroprusside	nitroprusside	RB
cord-006860-a3b8hyyr	2672	7	-	-	HYPH
cord-006860-a3b8hyyr	2672	8	induced	induce	VBN
cord-006860-a3b8hyyr	2672	9	cGMP	cGMP	NNP
cord-006860-a3b8hyyr	2672	10	increase	increase	NN
cord-006860-a3b8hyyr	2672	11	was	be	VBD
cord-006860-a3b8hyyr	2672	12	similar	similar	JJ
cord-006860-a3b8hyyr	2672	13	in	in	IN
cord-006860-a3b8hyyr	2672	14	non	non	JJ
cord-006860-a3b8hyyr	2672	15	-	-	JJ
cord-006860-a3b8hyyr	2672	16	confluent	confluent	JJ
cord-006860-a3b8hyyr	2672	17	and	and	CC
cord-006860-a3b8hyyr	2672	18	confluent	confluent	JJ
cord-006860-a3b8hyyr	2672	19	cells	cell	NNS
cord-006860-a3b8hyyr	2672	20	.	.	.
cord-006860-a3b8hyyr	2673	1	The	the	DT
cord-006860-a3b8hyyr	2673	2	expression	expression	NN
cord-006860-a3b8hyyr	2673	3	of	of	IN
cord-006860-a3b8hyyr	2673	4	iNOS	inos	NN
cord-006860-a3b8hyyr	2673	5	and	and	CC
cord-006860-a3b8hyyr	2673	6	the	the	DT
cord-006860-a3b8hyyr	2673	7	high	high	JJ
cord-006860-a3b8hyyr	2673	8	NO	no	DT
cord-006860-a3b8hyyr	2673	9	production	production	NN
cord-006860-a3b8hyyr	2673	10	in	in	IN
cord-006860-a3b8hyyr	2673	11	LD	LD	NNP
cord-006860-a3b8hyyr	2673	12	-	-	HYPH
cord-006860-a3b8hyyr	2673	13	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2673	14	suggest	suggest	VBP
cord-006860-a3b8hyyr	2673	15	a	a	DT
cord-006860-a3b8hyyr	2673	16	role	role	NN
cord-006860-a3b8hyyr	2673	17	of	of	IN
cord-006860-a3b8hyyr	2673	18	endogenous	endogenous	JJ
cord-006860-a3b8hyyr	2673	19	NO	no	RB
cord-006860-a3b8hyyr	2673	20	in	in	IN
cord-006860-a3b8hyyr	2673	21	mediating	mediate	VBG
cord-006860-a3b8hyyr	2673	22	cell	cell	NN
cord-006860-a3b8hyyr	2673	23	proliferation	proliferation	NN
cord-006860-a3b8hyyr	2673	24	.	.	.
cord-006860-a3b8hyyr	2674	1	Indeed	indeed	RB
cord-006860-a3b8hyyr	2674	2	,	,	,
cord-006860-a3b8hyyr	2674	3	the	the	DT
cord-006860-a3b8hyyr	2674	4	NOS	NOS	NNP
cord-006860-a3b8hyyr	2674	5	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2674	6	L	L	NNP
cord-006860-a3b8hyyr	2674	7	-	-	HYPH
cord-006860-a3b8hyyr	2674	8	NMMA	NMMA	NNP
cord-006860-a3b8hyyr	2674	9	and	and	CC
cord-006860-a3b8hyyr	2674	10	L	L	NNP
cord-006860-a3b8hyyr	2674	11	-	-	HYPH
cord-006860-a3b8hyyr	2674	12	canavanine	canavanine	NN
cord-006860-a3b8hyyr	2674	13	inhibited	inhibit	VBD
cord-006860-a3b8hyyr	2674	14	[	[	-LRB-
cord-006860-a3b8hyyr	2674	15	~H]thymidine	~h]thymidine	JJ
cord-006860-a3b8hyyr	2674	16	incorporation	incorporation	NN
cord-006860-a3b8hyyr	2674	17	in	in	IN
cord-006860-a3b8hyyr	2674	18	LD	LD	NNP
cord-006860-a3b8hyyr	2674	19	-	-	HYPH
cord-006860-a3b8hyyr	2674	20	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2674	21	by	by	IN
cord-006860-a3b8hyyr	2674	22	60	60	CD
cord-006860-a3b8hyyr	2674	23	%	%	NN
cord-006860-a3b8hyyr	2674	24	.	.	.
cord-006860-a3b8hyyr	2675	1	On	on	IN
cord-006860-a3b8hyyr	2675	2	the	the	DT
cord-006860-a3b8hyyr	2675	3	+	+	NN
cord-006860-a3b8hyyr	2675	4	+	+	CC
cord-006860-a3b8hyyr	2675	5	nt	nt	RB
cord-006860-a3b8hyyr	2675	6	NO	no	NN
cord-006860-a3b8hyyr	2675	7	r	r	NN
cord-006860-a3b8hyyr	2676	1	UCtlOn	UCtlOn	NNP
cord-006860-a3b8hyyr	2676	2	ar	ar	NNP
cord-006860-a3b8hyyr	2677	1	x	x	NNP
cord-006860-a3b8hyyr	2677	2	r	r	NNP
cord-006860-a3b8hyyr	2677	3	d	d	NN
cord-006860-a3b8hyyr	2677	4	m	m	NN
cord-006860-a3b8hyyr	2678	1	other	other	JJ
cord-006860-a3b8hyyr	2678	2	hand	hand	NN
cord-006860-a3b8hyyr	2678	3	eNOS	enos	NN
cord-006860-a3b8hyyr	2678	4	and	and	CC
cord-006860-a3b8hyyr	2678	5	Ca	Ca	NNP
cord-006860-a3b8hyyr	2678	6	-depende	-depende	SYM
cord-006860-a3b8hyyr	2678	7	p	p	NN
cord-006860-a3b8hyyr	2678	8	od	od	NN
cord-006860-a3b8hyyr	2678	9	"	"	``
cord-006860-a3b8hyyr	2678	10	e	e	NN
cord-006860-a3b8hyyr	2678	11	e	e	NN
cord-006860-a3b8hyyr	2678	12	p	p	NN
cord-006860-a3b8hyyr	2678	13	esse	esse	NN
cord-006860-a3b8hyyr	2678	14	"	"	``
cord-006860-a3b8hyyr	2678	15	differentiated	differentiate	VBN
cord-006860-a3b8hyyr	2678	16	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	2678	17	and	and	CC
cord-006860-a3b8hyyr	2678	18	correspond	correspond	VB
cord-006860-a3b8hyyr	2678	19	to	to	IN
cord-006860-a3b8hyyr	2678	20	the	the	DT
cord-006860-a3b8hyyr	2678	21	ability	ability	NN
cord-006860-a3b8hyyr	2678	22	of	of	IN
cord-006860-a3b8hyyr	2678	23	the	the	DT
cord-006860-a3b8hyyr	2678	24	cells	cell	NNS
cord-006860-a3b8hyyr	2678	25	to	to	TO
cord-006860-a3b8hyyr	2678	26	regulate	regulate	VB
cord-006860-a3b8hyyr	2678	27	vascular	vascular	JJ
cord-006860-a3b8hyyr	2678	28	tone	tone	NN
cord-006860-a3b8hyyr	2678	29	and	and	CC
cord-006860-a3b8hyyr	2678	30	platelet	platelet	NN
cord-006860-a3b8hyyr	2678	31	activation	activation	NN
cord-006860-a3b8hyyr	2678	32	.	.	.
cord-006860-a3b8hyyr	2679	1	The	the	DT
cord-006860-a3b8hyyr	2679	2	processes	process	NNS
cord-006860-a3b8hyyr	2679	3	of	of	IN
cord-006860-a3b8hyyr	2679	4	replication	replication	NN
cord-006860-a3b8hyyr	2679	5	,	,	,
cord-006860-a3b8hyyr	2679	6	maturation	maturation	NN
cord-006860-a3b8hyyr	2679	7	and	and	CC
cord-006860-a3b8hyyr	2679	8	motility	motility	NN
cord-006860-a3b8hyyr	2679	9	of	of	IN
cord-006860-a3b8hyyr	2679	10	progenitor	progenitor	NN
cord-006860-a3b8hyyr	2679	11	cells	cell	NNS
cord-006860-a3b8hyyr	2679	12	of	of	IN
cord-006860-a3b8hyyr	2679	13	different	different	JJ
cord-006860-a3b8hyyr	2679	14	lineages	lineage	NNS
cord-006860-a3b8hyyr	2679	15	in	in	IN
cord-006860-a3b8hyyr	2679	16	the	the	DT
cord-006860-a3b8hyyr	2679	17	bone	bone	NN
cord-006860-a3b8hyyr	2679	18	marrow	marrow	NN
cord-006860-a3b8hyyr	2679	19	are	be	VBP
cord-006860-a3b8hyyr	2679	20	tightly	tightly	RB
cord-006860-a3b8hyyr	2679	21	regulated	regulate	VBN
cord-006860-a3b8hyyr	2679	22	,	,	,
cord-006860-a3b8hyyr	2679	23	particulady	particulady	VBN
cord-006860-a3b8hyyr	2679	24	by	by	IN
cord-006860-a3b8hyyr	2679	25	various	various	JJ
cord-006860-a3b8hyyr	2679	26	cellular	cellular	JJ
cord-006860-a3b8hyyr	2679	27	contacts	contact	NNS
cord-006860-a3b8hyyr	2679	28	and	and	CC
cord-006860-a3b8hyyr	2679	29	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2679	30	modulation	modulation	NN
cord-006860-a3b8hyyr	2679	31	involving	involve	VBG
cord-006860-a3b8hyyr	2679	32	pericellular	pericellular	JJ
cord-006860-a3b8hyyr	2679	33	proteolysis	proteolysis	NN
cord-006860-a3b8hyyr	2679	34	.	.	.
cord-006860-a3b8hyyr	2680	1	While	while	IN
cord-006860-a3b8hyyr	2680	2	mononuclear	mononuclear	JJ
cord-006860-a3b8hyyr	2680	3	phagocytes	phagocyte	NNS
cord-006860-a3b8hyyr	2680	4	and	and	CC
cord-006860-a3b8hyyr	2680	5	related	related	JJ
cord-006860-a3b8hyyr	2680	6	cell	cell	NN
cord-006860-a3b8hyyr	2680	7	lines	line	NNS
cord-006860-a3b8hyyr	2680	8	are	be	VBP
cord-006860-a3b8hyyr	2680	9	well	well	RB
cord-006860-a3b8hyyr	2680	10	characterized	characterize	VBN
cord-006860-a3b8hyyr	2680	11	for	for	IN
cord-006860-a3b8hyyr	2680	12	surface	surface	NN
cord-006860-a3b8hyyr	2680	13	localized	localize	VBN
cord-006860-a3b8hyyr	2680	14	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	2680	15	activation	activation	NN
cord-006860-a3b8hyyr	2680	16	by	by	IN
cord-006860-a3b8hyyr	2680	17	receptor	receptor	NN
cord-006860-a3b8hyyr	2680	18	bound	bind	VBN
cord-006860-a3b8hyyr	2680	19	urokinase	urokinase	NN
cord-006860-a3b8hyyr	2680	20	,	,	,
cord-006860-a3b8hyyr	2680	21	megakaryocytes	megakaryocytes	NNP
cord-006860-a3b8hyyr	2680	22	are	be	VBP
cord-006860-a3b8hyyr	2680	23	poorly	poorly	RB
cord-006860-a3b8hyyr	2680	24	described	describe	VBN
cord-006860-a3b8hyyr	2680	25	in	in	IN
cord-006860-a3b8hyyr	2680	26	this	this	DT
cord-006860-a3b8hyyr	2680	27	respect	respect	NN
cord-006860-a3b8hyyr	2680	28	.	.	.
cord-006860-a3b8hyyr	2681	1	In	in	IN
cord-006860-a3b8hyyr	2681	2	the	the	DT
cord-006860-a3b8hyyr	2681	3	present	present	JJ
cord-006860-a3b8hyyr	2681	4	study	study	NN
cord-006860-a3b8hyyr	2681	5	the	the	DT
cord-006860-a3b8hyyr	2681	6	expression	expression	NN
cord-006860-a3b8hyyr	2681	7	of	of	IN
cord-006860-a3b8hyyr	2681	8	mRNA	mRNA	NNP
cord-006860-a3b8hyyr	2681	9	of	of	IN
cord-006860-a3b8hyyr	2681	10	urokinase	urokinase	NNP
cord-006860-a3b8hyyr	2681	11	receptor	receptor	NN
cord-006860-a3b8hyyr	2681	12	in	in	IN
cord-006860-a3b8hyyr	2681	13	megakaryoblastic	megakaryoblastic	JJ
cord-006860-a3b8hyyr	2681	14	cell	cell	NN
cord-006860-a3b8hyyr	2681	15	lines	line	NNS
cord-006860-a3b8hyyr	2682	1	CHRF-280	CHRF-280	NNP
cord-006860-a3b8hyyr	2682	2	,	,	,
cord-006860-a3b8hyyr	2682	3	Dami	Dami	NNP
cord-006860-a3b8hyyr	2682	4	and	and	CC
cord-006860-a3b8hyyr	2682	5	Meg01	Meg01	NNP
cord-006860-a3b8hyyr	2682	6	was	be	VBD
cord-006860-a3b8hyyr	2682	7	found	find	VBN
cord-006860-a3b8hyyr	2682	8	at	at	IN
cord-006860-a3b8hyyr	2682	9	a	a	DT
cord-006860-a3b8hyyr	2682	10	low	low	JJ
cord-006860-a3b8hyyr	2682	11	basal	basal	NN
cord-006860-a3b8hyyr	2682	12	level	level	NN
cord-006860-a3b8hyyr	2682	13	and	and	CC
cord-006860-a3b8hyyr	2682	14	increased	increase	VBD
cord-006860-a3b8hyyr	2682	15	5	5	CD
cord-006860-a3b8hyyr	2682	16	-	-	SYM
cord-006860-a3b8hyyr	2682	17	10	10	CD
cord-006860-a3b8hyyr	2682	18	fold	fold	NN
cord-006860-a3b8hyyr	2682	19	after	after	IN
cord-006860-a3b8hyyr	2682	20	PMA	PMA	NNP
cord-006860-a3b8hyyr	2682	21	-	-	HYPH
cord-006860-a3b8hyyr	2682	22	treatment	treatment	NN
cord-006860-a3b8hyyr	2682	23	.	.	.
cord-006860-a3b8hyyr	2683	1	Urokinase	Urokinase	NNP
cord-006860-a3b8hyyr	2683	2	receptor	receptor	NN
cord-006860-a3b8hyyr	2683	3	mRNA	mrna	NN
cord-006860-a3b8hyyr	2683	4	levels	level	NNS
cord-006860-a3b8hyyr	2683	5	remained	remain	VBD
cord-006860-a3b8hyyr	2683	6	differentiation	differentiation	NN
cord-006860-a3b8hyyr	2683	7	dependent	dependent	JJ
cord-006860-a3b8hyyr	2683	8	elevated	elevated	JJ
cord-006860-a3b8hyyr	2683	9	for	for	IN
cord-006860-a3b8hyyr	2683	10	up	up	IN
cord-006860-a3b8hyyr	2683	11	to	to	TO
cord-006860-a3b8hyyr	2683	12	5	5	CD
cord-006860-a3b8hyyr	2683	13	days	day	NNS
cord-006860-a3b8hyyr	2683	14	.	.	.
cord-006860-a3b8hyyr	2684	1	Functional	functional	JJ
cord-006860-a3b8hyyr	2684	2	analysis	analysis	NN
cord-006860-a3b8hyyr	2684	3	of	of	IN
cord-006860-a3b8hyyr	2684	4	uPAR	upar	JJ
cord-006860-a3b8hyyr	2684	5	expression	expression	NN
cord-006860-a3b8hyyr	2684	6	on	on	IN
cord-006860-a3b8hyyr	2684	7	the	the	DT
cord-006860-a3b8hyyr	2684	8	cell	cell	NN
cord-006860-a3b8hyyr	2684	9	surface	surface	NN
cord-006860-a3b8hyyr	2684	10	was	be	VBD
cord-006860-a3b8hyyr	2684	11	documented	document	VBN
cord-006860-a3b8hyyr	2684	12	immunologically	immunologically	RB
cord-006860-a3b8hyyr	2684	13	by	by	IN
cord-006860-a3b8hyyr	2684	14	FACS	FACS	NNP
cord-006860-a3b8hyyr	2684	15	-	-	HYPH
cord-006860-a3b8hyyr	2684	16	anatysis	anatysis	NNP
cord-006860-a3b8hyyr	2684	17	and	and	CC
cord-006860-a3b8hyyr	2684	18	on	on	IN
cord-006860-a3b8hyyr	2684	19	the	the	DT
cord-006860-a3b8hyyr	2684	20	functional	functional	JJ
cord-006860-a3b8hyyr	2684	21	level	level	NN
cord-006860-a3b8hyyr	2684	22	by	by	IN
cord-006860-a3b8hyyr	2684	23	direct	direct	JJ
cord-006860-a3b8hyyr	2684	24	binding	binding	NN
cord-006860-a3b8hyyr	2684	25	of	of	IN
cord-006860-a3b8hyyr	2684	26	radio	radio	NN
cord-006860-a3b8hyyr	2684	27	-	-	HYPH
cord-006860-a3b8hyyr	2684	28	labeled	label	VBN
cord-006860-a3b8hyyr	2684	29	amine	amine	NN
cord-006860-a3b8hyyr	2684	30	-	-	HYPH
cord-006860-a3b8hyyr	2684	31	terminal	terminal	NN
cord-006860-a3b8hyyr	2684	32	fragment	fragment	NN
cord-006860-a3b8hyyr	2684	33	of	of	IN
cord-006860-a3b8hyyr	2684	34	urokJnase	urokJnase	NNP
cord-006860-a3b8hyyr	2684	35	and	and	CC
cord-006860-a3b8hyyr	2684	36	mirrawed	mirrawe	VBD
cord-006860-a3b8hyyr	2684	37	the	the	DT
cord-006860-a3b8hyyr	2684	38	increase	increase	NN
cord-006860-a3b8hyyr	2684	39	in	in	IN
cord-006860-a3b8hyyr	2684	40	urakinase	urakinase	NNP
cord-006860-a3b8hyyr	2684	41	recptar	recptar	NNP
cord-006860-a3b8hyyr	2684	42	mRNA	mRNA	NNP
cord-006860-a3b8hyyr	2684	43	level	level	NN
cord-006860-a3b8hyyr	2684	44	.	.	.
cord-006860-a3b8hyyr	2685	1	As	as	IN
cord-006860-a3b8hyyr	2685	2	expected	expect	VBN
cord-006860-a3b8hyyr	2685	3	,	,	,
cord-006860-a3b8hyyr	2685	4	antibody	antibody	NN
cord-006860-a3b8hyyr	2685	5	and	and	CC
cord-006860-a3b8hyyr	2685	6	ligand	ligand	NN
cord-006860-a3b8hyyr	2685	7	binding	binding	NN
cord-006860-a3b8hyyr	2685	8	was	be	VBD
cord-006860-a3b8hyyr	2685	9	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	2685	10	towards	towards	IN
cord-006860-a3b8hyyr	2685	11	treatment	treatment	NN
cord-006860-a3b8hyyr	2685	12	with	with	IN
cord-006860-a3b8hyyr	2685	13	phosphatidyl	phosphatidyl	NN
cord-006860-a3b8hyyr	2685	14	-	-	HYPH
cord-006860-a3b8hyyr	2685	15	inositol	inositol	NN
cord-006860-a3b8hyyr	2685	16	-	-	HYPH
cord-006860-a3b8hyyr	2685	17	specific	specific	JJ
cord-006860-a3b8hyyr	2685	18	phospholipase	phospholipase	NN
cord-006860-a3b8hyyr	2685	19	C	c	NN
cord-006860-a3b8hyyr	2685	20	,	,	,
cord-006860-a3b8hyyr	2685	21	since	since	IN
cord-006860-a3b8hyyr	2685	22	the	the	DT
cord-006860-a3b8hyyr	2685	23	urokinase	urokinase	NN
cord-006860-a3b8hyyr	2685	24	receptor	receptor	NN
cord-006860-a3b8hyyr	2685	25	belongs	belong	VBZ
cord-006860-a3b8hyyr	2685	26	to	to	IN
cord-006860-a3b8hyyr	2685	27	the	the	DT
cord-006860-a3b8hyyr	2685	28	group	group	NN
cord-006860-a3b8hyyr	2685	29	of	of	IN
cord-006860-a3b8hyyr	2685	30	GPI	GPI	NNP
cord-006860-a3b8hyyr	2685	31	-	-	HYPH
cord-006860-a3b8hyyr	2685	32	anchored	anchor	VBN
cord-006860-a3b8hyyr	2685	33	receptors	receptor	NNS
cord-006860-a3b8hyyr	2685	34	.	.	.
cord-006860-a3b8hyyr	2686	1	In	in	IN
cord-006860-a3b8hyyr	2686	2	cultered	cultere	VBN
cord-006860-a3b8hyyr	2686	3	megakaryocytes	megakaryocytes	NNP
cord-006860-a3b8hyyr	2686	4	derived	derive	VBN
cord-006860-a3b8hyyr	2686	5	from	from	IN
cord-006860-a3b8hyyr	2686	6	bone	bone	NN
cord-006860-a3b8hyyr	2686	7	marrow	marrow	NN
cord-006860-a3b8hyyr	2686	8	urokinase	urokinase	NN
cord-006860-a3b8hyyr	2686	9	receptor	receptor	NN
cord-006860-a3b8hyyr	2686	10	mRNA	mRNA	NNP
cord-006860-a3b8hyyr	2686	11	was	be	VBD
cord-006860-a3b8hyyr	2686	12	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	2686	13	by	by	IN
cord-006860-a3b8hyyr	2686	14	RT	RT	NNP
cord-006860-a3b8hyyr	2686	15	-	-	HYPH
cord-006860-a3b8hyyr	2686	16	PCR	PCR	NNP
cord-006860-a3b8hyyr	2686	17	,	,	,
cord-006860-a3b8hyyr	2686	18	as	as	RB
cord-006860-a3b8hyyr	2686	19	well	well	RB
cord-006860-a3b8hyyr	2686	20	.	.	.
cord-006860-a3b8hyyr	2687	1	These	these	DT
cord-006860-a3b8hyyr	2687	2	results	result	NNS
cord-006860-a3b8hyyr	2687	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	2687	4	a	a	DT
cord-006860-a3b8hyyr	2687	5	differentiation	differentiation	NN
cord-006860-a3b8hyyr	2687	6	-	-	HYPH
cord-006860-a3b8hyyr	2687	7	dependent	dependent	JJ
cord-006860-a3b8hyyr	2687	8	increase	increase	NN
cord-006860-a3b8hyyr	2687	9	of	of	IN
cord-006860-a3b8hyyr	2687	10	urokinase	urokinase	NN
cord-006860-a3b8hyyr	2687	11	receptor	receptor	NN
cord-006860-a3b8hyyr	2687	12	expression	expression	NN
cord-006860-a3b8hyyr	2687	13	on	on	IN
cord-006860-a3b8hyyr	2687	14	cells	cell	NNS
cord-006860-a3b8hyyr	2687	15	of	of	IN
cord-006860-a3b8hyyr	2687	16	megakaryoblastic	megakaryoblastic	JJ
cord-006860-a3b8hyyr	2687	17	cell	cell	NN
cord-006860-a3b8hyyr	2687	18	lineage	lineage	NN
cord-006860-a3b8hyyr	2687	19	suggesting	suggest	VBG
cord-006860-a3b8hyyr	2687	20	the	the	DT
cord-006860-a3b8hyyr	2687	21	participation	participation	NN
cord-006860-a3b8hyyr	2687	22	of	of	IN
cord-006860-a3b8hyyr	2687	23	urokinase	urokinase	NN
cord-006860-a3b8hyyr	2687	24	dependent	dependent	JJ
cord-006860-a3b8hyyr	2687	25	events	event	NNS
cord-006860-a3b8hyyr	2687	26	during	during	IN
cord-006860-a3b8hyyr	2687	27	maturation	maturation	NN
cord-006860-a3b8hyyr	2687	28	process	process	NN
cord-006860-a3b8hyyr	2687	29	and	and	CC
cord-006860-a3b8hyyr	2687	30	intravasation	intravasation	NN
cord-006860-a3b8hyyr	2687	31	of	of	IN
cord-006860-a3b8hyyr	2687	32	these	these	DT
cord-006860-a3b8hyyr	2687	33	platelet	platelet	NN
cord-006860-a3b8hyyr	2687	34	precurors	precuror	NNS
cord-006860-a3b8hyyr	2687	35	.	.	.
cord-006860-a3b8hyyr	2687	36	 	 	_SP
cord-006860-a3b8hyyr	2688	1	Regulation	regulation	NN
cord-006860-a3b8hyyr	2688	2	of	of	IN
cord-006860-a3b8hyyr	2688	3	AM	AM	NNP
cord-006860-a3b8hyyr	2688	4	gene	gene	NN
cord-006860-a3b8hyyr	2688	5	expression	expression	NN
cord-006860-a3b8hyyr	2688	6	may	may	MD
cord-006860-a3b8hyyr	2688	7	be	be	VB
cord-006860-a3b8hyyr	2688	8	coupled	couple	VBN
cord-006860-a3b8hyyr	2688	9	to	to	IN
cord-006860-a3b8hyyr	2688	10	oxidative	oxidative	JJ
cord-006860-a3b8hyyr	2688	11	stress	stress	NN
cord-006860-a3b8hyyr	2688	12	through	through	IN
cord-006860-a3b8hyyr	2688	13	redox	redox	JJ
cord-006860-a3b8hyyr	2688	14	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	2688	15	transcriptional	transcriptional	JJ
cord-006860-a3b8hyyr	2688	16	regulatory	regulatory	JJ
cord-006860-a3b8hyyr	2688	17	factors	factor	NNS
cord-006860-a3b8hyyr	2688	18	.	.	.
cord-006860-a3b8hyyr	2689	1	The	the	DT
cord-006860-a3b8hyyr	2689	2	aim	aim	NN
cord-006860-a3b8hyyr	2689	3	of	of	IN
cord-006860-a3b8hyyr	2689	4	this	this	DT
cord-006860-a3b8hyyr	2689	5	study	study	NN
cord-006860-a3b8hyyr	2689	6	was	be	VBD
cord-006860-a3b8hyyr	2689	7	to	to	TO
cord-006860-a3b8hyyr	2689	8	investigate	investigate	VB
cord-006860-a3b8hyyr	2689	9	the	the	DT
cord-006860-a3b8hyyr	2689	10	influence	influence	NN
cord-006860-a3b8hyyr	2689	11	of	of	IN
cord-006860-a3b8hyyr	2689	12	selected	select	VBN
cord-006860-a3b8hyyr	2689	13	antioxidants	antioxidant	NNS
cord-006860-a3b8hyyr	2689	14	on	on	IN
cord-006860-a3b8hyyr	2689	15	TNFa	TNFa	NNS
cord-006860-a3b8hyyr	2689	16	(	(	-LRB-
cord-006860-a3b8hyyr	2689	17	100	100	CD
cord-006860-a3b8hyyr	2689	18	U	U	NNP
cord-006860-a3b8hyyr	2689	19	/	/	SYM
cord-006860-a3b8hyyr	2689	20	ml	ml	XX
cord-006860-a3b8hyyr	2689	21	,	,	,
cord-006860-a3b8hyyr	2689	22	6	6	CD
cord-006860-a3b8hyyr	2689	23	h)-induced	h)-induced	CD
cord-006860-a3b8hyyr	2689	24	surface	surface	NN
cord-006860-a3b8hyyr	2689	25	expression	expression	NN
cord-006860-a3b8hyyr	2689	26	of	of	IN
cord-006860-a3b8hyyr	2689	27	ELAM	ELAM	NNP
cord-006860-a3b8hyyr	2689	28	-	-	:
cord-006860-a3b8hyyr	2689	29	I	I	NNP
cord-006860-a3b8hyyr	2689	30	,	,	,
cord-006860-a3b8hyyr	2689	31	ICAM	ICAM	NNP
cord-006860-a3b8hyyr	2689	32	-	-	HYPH
cord-006860-a3b8hyyr	2689	33	I	I	NNP
cord-006860-a3b8hyyr	2689	34	and	and	CC
cord-006860-a3b8hyyr	2689	35	VCAM	VCAM	NNP
cord-006860-a3b8hyyr	2689	36	-	-	HYPH
cord-006860-a3b8hyyr	2689	37	I	-PRON-	PRP
cord-006860-a3b8hyyr	2689	38	in	in	IN
cord-006860-a3b8hyyr	2689	39	human	human	JJ
cord-006860-a3b8hyyr	2689	40	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	2689	41	vein	vein	NN
cord-006860-a3b8hyyr	2689	42	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	2689	43	cells	cell	NNS
cord-006860-a3b8hyyr	2689	44	.	.	.
cord-006860-a3b8hyyr	2690	1	AM	AM	NNP
cord-006860-a3b8hyyr	2690	2	expression	expression	NN
cord-006860-a3b8hyyr	2690	3	was	be	VBD
cord-006860-a3b8hyyr	2690	4	determined	determine	VBN
cord-006860-a3b8hyyr	2690	5	by	by	IN
cord-006860-a3b8hyyr	2690	6	quantitative	quantitative	JJ
cord-006860-a3b8hyyr	2690	7	flow	flow	NN
cord-006860-a3b8hyyr	2690	8	cytometry	cytometry	NN
cord-006860-a3b8hyyr	2690	9	and	and	CC
cord-006860-a3b8hyyr	2690	10	immunohistochemistry	immunohistochemistry	NN
cord-006860-a3b8hyyr	2690	11	(	(	-LRB-
cord-006860-a3b8hyyr	2690	12	alkaline	alkaline	JJ
cord-006860-a3b8hyyr	2690	13	phosphatase	phosphatase	NN
cord-006860-a3b8hyyr	2690	14	anti	anti	JJ
cord-006860-a3b8hyyr	2690	15	-	-	JJ
cord-006860-a3b8hyyr	2690	16	alkaline	alkaline	JJ
cord-006860-a3b8hyyr	2690	17	phosphatase	phosphatase	NN
cord-006860-a3b8hyyr	2690	18	method	method	NN
cord-006860-a3b8hyyr	2690	19	)	)	-RRB-
cord-006860-a3b8hyyr	2690	20	.	.	.
cord-006860-a3b8hyyr	2691	1	The	the	DT
cord-006860-a3b8hyyr	2691	2	following	follow	VBG
cord-006860-a3b8hyyr	2691	3	antioxidants	antioxidant	NNS
cord-006860-a3b8hyyr	2691	4	were	be	VBD
cord-006860-a3b8hyyr	2691	5	tested	test	VBN
cord-006860-a3b8hyyr	2691	6	:	:	:
cord-006860-a3b8hyyr	2691	7	pyrrolidine	pyrrolidine	NNP
cord-006860-a3b8hyyr	2691	8	dithiocarbamate	dithiocarbamate	NNP
cord-006860-a3b8hyyr	2691	9	(	(	-LRB-
cord-006860-a3b8hyyr	2691	10	PDTC	PDTC	NNP
cord-006860-a3b8hyyr	2691	11	)	)	-RRB-
cord-006860-a3b8hyyr	2691	12	,	,	,
cord-006860-a3b8hyyr	2691	13	N	n	CD
cord-006860-a3b8hyyr	2691	14	-	-	HYPH
cord-006860-a3b8hyyr	2691	15	acetylcysteine	acetylcysteine	NN
cord-006860-a3b8hyyr	2691	16	(	(	-LRB-
cord-006860-a3b8hyyr	2691	17	NAC	NAC	NNP
cord-006860-a3b8hyyr	2691	18	)	)	-RRB-
cord-006860-a3b8hyyr	2691	19	,	,	,
cord-006860-a3b8hyyr	2691	20	glutathionemonoethyl	glutathionemonoethyl	NNP
cord-006860-a3b8hyyr	2691	21	ester	ester	NN
cord-006860-a3b8hyyr	2691	22	(	(	-LRB-
cord-006860-a3b8hyyr	2691	23	GSHMEE	GSHMEE	NNP
cord-006860-a3b8hyyr	2691	24	)	)	-RRB-
cord-006860-a3b8hyyr	2691	25	,	,	,
cord-006860-a3b8hyyr	2691	26	probucol	probucol	NNP
cord-006860-a3b8hyyr	2691	27	and	and	CC
cord-006860-a3b8hyyr	2691	28	the	the	DT
cord-006860-a3b8hyyr	2691	29	estradiol	estradiol	NN
cord-006860-a3b8hyyr	2691	30	-	-	HYPH
cord-006860-a3b8hyyr	2691	31	derived	derive	VBN
cord-006860-a3b8hyyr	2691	32	scavestrogens	scavestrogens	NNP
cord-006860-a3b8hyyr	2691	33	J824	J824	''
cord-006860-a3b8hyyr	2691	34	,	,	,
cord-006860-a3b8hyyr	2691	35	J861	J861	NNP
cord-006860-a3b8hyyr	2691	36	,	,	,
cord-006860-a3b8hyyr	2691	37	J901	J901	NNP
cord-006860-a3b8hyyr	2691	38	.	.	.
cord-006860-a3b8hyyr	2692	1	Additionally	additionally	RB
cord-006860-a3b8hyyr	2692	2	,	,	,
cord-006860-a3b8hyyr	2692	3	17fi	17fi	JJ
cord-006860-a3b8hyyr	2692	4	-	-	HYPH
cord-006860-a3b8hyyr	2692	5	estradiol	estradiol	NN
cord-006860-a3b8hyyr	2692	6	was	be	VBD
cord-006860-a3b8hyyr	2692	7	examined	examine	VBN
cord-006860-a3b8hyyr	2692	8	.	.	.
cord-006860-a3b8hyyr	2693	1	The	the	DT
cord-006860-a3b8hyyr	2693	2	used	use	VBN
cord-006860-a3b8hyyr	2693	3	concentrations	concentration	NNS
cord-006860-a3b8hyyr	2693	4	were	be	VBD
cord-006860-a3b8hyyr	2693	5	1	1	CD
cord-006860-a3b8hyyr	2693	6	-	-	SYM
cord-006860-a3b8hyyr	2693	7	5	5	CD
cord-006860-a3b8hyyr	2693	8	mM	mm	CD
cord-006860-a3b8hyyr	2693	9	for	for	IN
cord-006860-a3b8hyyr	2693	10	NAC	NAC	NNP
cord-006860-a3b8hyyr	2693	11	and	and	CC
cord-006860-a3b8hyyr	2693	12	GSHMEE	GSHMEE	NNP
cord-006860-a3b8hyyr	2693	13	and	and	CC
cord-006860-a3b8hyyr	2693	14	1	1	CD
cord-006860-a3b8hyyr	2693	15	-	-	SYM
cord-006860-a3b8hyyr	2693	16	100	100	CD
cord-006860-a3b8hyyr	2693	17	~M	~M	NFP
cord-006860-a3b8hyyr	2693	18	for	for	IN
cord-006860-a3b8hyyr	2693	19	all	all	DT
cord-006860-a3b8hyyr	2693	20	other	other	JJ
cord-006860-a3b8hyyr	2693	21	substances	substance	NNS
cord-006860-a3b8hyyr	2693	22	.	.	.
cord-006860-a3b8hyyr	2694	1	According	accord	VBG
cord-006860-a3b8hyyr	2694	2	to	to	IN
cord-006860-a3b8hyyr	2694	3	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2694	4	influence	influence	NN
cord-006860-a3b8hyyr	2694	5	on	on	IN
cord-006860-a3b8hyyr	2694	6	TNF	TNF	NNP
cord-006860-a3b8hyyr	2694	7	-	-	HYPH
cord-006860-a3b8hyyr	2694	8	induced	induce	VBN
cord-006860-a3b8hyyr	2694	9	AM	AM	NNP
cord-006860-a3b8hyyr	2694	10	expression	expression	NN
cord-006860-a3b8hyyr	2694	11	,	,	,
cord-006860-a3b8hyyr	2694	12	the	the	DT
cord-006860-a3b8hyyr	2694	13	tested	test	VBN
cord-006860-a3b8hyyr	2694	14	antioxidants	antioxidant	NNS
cord-006860-a3b8hyyr	2694	15	can	can	MD
cord-006860-a3b8hyyr	2694	16	be	be	VB
cord-006860-a3b8hyyr	2694	17	divided	divide	VBN
cord-006860-a3b8hyyr	2694	18	into	into	IN
cord-006860-a3b8hyyr	2694	19	three	three	CD
cord-006860-a3b8hyyr	2694	20	groups	group	NNS
cord-006860-a3b8hyyr	2694	21	:	:	:
cord-006860-a3b8hyyr	2695	1	1	1	LS
cord-006860-a3b8hyyr	2695	2	)	)	-RRB-
cord-006860-a3b8hyyr	2695	3	PDTC	PDTC	NNP
cord-006860-a3b8hyyr	2695	4	,	,	,
cord-006860-a3b8hyyr	2695	5	NAC	NAC	NNP
cord-006860-a3b8hyyr	2695	6	and	and	CC
cord-006860-a3b8hyyr	2695	7	GSHMEE	GSHMEE	NNP
cord-006860-a3b8hyyr	2695	8	inhibit	inhibit	VBP
cord-006860-a3b8hyyr	2695	9	the	the	DT
cord-006860-a3b8hyyr	2695	10	expression	expression	NN
cord-006860-a3b8hyyr	2695	11	of	of	IN
cord-006860-a3b8hyyr	2695	12	all	all	DT
cord-006860-a3b8hyyr	2695	13	three	three	CD
cord-006860-a3b8hyyr	2695	14	AM	am	NN
cord-006860-a3b8hyyr	2695	15	,	,	,
cord-006860-a3b8hyyr	2695	16	2	2	CD
cord-006860-a3b8hyyr	2695	17	)	)	-RRB-
cord-006860-a3b8hyyr	2695	18	J861	J861	NNPS
cord-006860-a3b8hyyr	2695	19	and	and	CC
cord-006860-a3b8hyyr	2695	20	J824	j824	PRP
cord-006860-a3b8hyyr	2695	21	reduce	reduce	VB
cord-006860-a3b8hyyr	2695	22	VCAM	VCAM	NNP
cord-006860-a3b8hyyr	2695	23	-	-	HYPH
cord-006860-a3b8hyyr	2695	24	I	I	NNP
cord-006860-a3b8hyyr	2695	25	and	and	CC
cord-006860-a3b8hyyr	2695	26	ICAM	ICAM	NNP
cord-006860-a3b8hyyr	2695	27	-	-	HYPH
cord-006860-a3b8hyyr	2695	28	I	I	NNP
cord-006860-a3b8hyyr	2695	29	and	and	CC
cord-006860-a3b8hyyr	2695	30	increase	increase	VB
cord-006860-a3b8hyyr	2695	31	ELAM	ELAM	NNP
cord-006860-a3b8hyyr	2695	32	-	-	HYPH
cord-006860-a3b8hyyr	2695	33	I	I	NNP
cord-006860-a3b8hyyr	2695	34	,	,	,
cord-006860-a3b8hyyr	2695	35	3	3	CD
cord-006860-a3b8hyyr	2695	36	)	)	-RRB-
cord-006860-a3b8hyyr	2695	37	J901	J901	NNPS
cord-006860-a3b8hyyr	2695	38	and	and	CC
cord-006860-a3b8hyyr	2695	39	probucol	probucol	NNP
cord-006860-a3b8hyyr	2695	40	show	show	VBP
cord-006860-a3b8hyyr	2695	41	no	no	DT
cord-006860-a3b8hyyr	2695	42	effect	effect	NN
cord-006860-a3b8hyyr	2695	43	.	.	.
cord-006860-a3b8hyyr	2696	1	17fl	17fl	JJ
cord-006860-a3b8hyyr	2696	2	-	-	HYPH
cord-006860-a3b8hyyr	2696	3	estradiol	estradiol	NN
cord-006860-a3b8hyyr	2696	4	elicits	elicit	VBZ
cord-006860-a3b8hyyr	2696	5	a	a	DT
cord-006860-a3b8hyyr	2696	6	potentiation	potentiation	NN
cord-006860-a3b8hyyr	2696	7	of	of	IN
cord-006860-a3b8hyyr	2696	8	TNFa	TNFa	NNP
cord-006860-a3b8hyyr	2696	9	-	-	HYPH
cord-006860-a3b8hyyr	2696	10	induced	induce	VBN
cord-006860-a3b8hyyr	2696	11	expression	expression	NN
cord-006860-a3b8hyyr	2696	12	of	of	IN
cord-006860-a3b8hyyr	2696	13	all	all	DT
cord-006860-a3b8hyyr	2696	14	three	three	CD
cord-006860-a3b8hyyr	2696	15	AM	am	NN
cord-006860-a3b8hyyr	2696	16	.	.	.
cord-006860-a3b8hyyr	2697	1	TNFa	TNFa	NNP
cord-006860-a3b8hyyr	2697	2	-	-	HYPH
cord-006860-a3b8hyyr	2697	3	induced	induce	VBN
cord-006860-a3b8hyyr	2697	4	VCAM	VCAM	NNP
cord-006860-a3b8hyyr	2698	1	-I	-i	DT
cord-006860-a3b8hyyr	2698	2	expression	expression	NN
cord-006860-a3b8hyyr	2698	3	was	be	VBD
cord-006860-a3b8hyyr	2698	4	most	most	RBS
cord-006860-a3b8hyyr	2698	5	effectively	effectively	RB
cord-006860-a3b8hyyr	2698	6	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	2698	7	by	by	IN
cord-006860-a3b8hyyr	2698	8	PTDC	PTDC	NNP
cord-006860-a3b8hyyr	2698	9	and	and	CC
cord-006860-a3b8hyyr	2698	10	J861	J861	NNP
cord-006860-a3b8hyyr	2699	1	(	(	-LRB-
cord-006860-a3b8hyyr	2699	2	100	100	CD
cord-006860-a3b8hyyr	2699	3	eM	eM	NNS
cord-006860-a3b8hyyr	2699	4	:	:	:
cord-006860-a3b8hyyr	2699	5	68	68	CD
cord-006860-a3b8hyyr	2699	6	%	%	NN
cord-006860-a3b8hyyr	2699	7	and	and	CC
cord-006860-a3b8hyyr	2699	8	78	78	CD
cord-006860-a3b8hyyr	2699	9	%	%	NN
cord-006860-a3b8hyyr	2699	10	inhibition	inhibition	NN
cord-006860-a3b8hyyr	2699	11	,	,	,
cord-006860-a3b8hyyr	2699	12	respectively	respectively	RB
cord-006860-a3b8hyyr	2699	13	)	)	-RRB-
cord-006860-a3b8hyyr	2699	14	.	.	.
cord-006860-a3b8hyyr	2700	1	The	the	DT
cord-006860-a3b8hyyr	2700	2	best	good	JJS
cord-006860-a3b8hyyr	2700	3	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2700	4	of	of	IN
cord-006860-a3b8hyyr	2700	5	ICAM	ICAM	NNP
cord-006860-a3b8hyyr	2700	6	-	-	HYPH
cord-006860-a3b8hyyr	2700	7	I	I	NNP
cord-006860-a3b8hyyr	2700	8	induction	induction	NN
cord-006860-a3b8hyyr	2700	9	were	be	VBD
cord-006860-a3b8hyyr	2700	10	PDTC	PDTC	NNP
cord-006860-a3b8hyyr	2700	11	(	(	-LRB-
cord-006860-a3b8hyyr	2700	12	100	100	CD
cord-006860-a3b8hyyr	2701	1	~M	~m	JJ
cord-006860-a3b8hyyr	2701	2	:	:	:
cord-006860-a3b8hyyr	2702	1	51	51	CD
cord-006860-a3b8hyyr	2702	2	%	%	NN
cord-006860-a3b8hyyr	2702	3	inhibition	inhibition	NN
cord-006860-a3b8hyyr	2702	4	)	)	-RRB-
cord-006860-a3b8hyyr	2702	5	and	and	CC
cord-006860-a3b8hyyr	2702	6	J824	J824	NNP
cord-006860-a3b8hyyr	2702	7	(	(	-LRB-
cord-006860-a3b8hyyr	2702	8	100	100	CD
cord-006860-a3b8hyyr	2702	9	t	t	NN
cord-006860-a3b8hyyr	2703	1	~M	~m	JJ
cord-006860-a3b8hyyr	2703	2	:	:	:
cord-006860-a3b8hyyr	2703	3	47	47	CD
cord-006860-a3b8hyyr	2703	4	%	%	NN
cord-006860-a3b8hyyr	2703	5	inhibition	inhibition	NN
cord-006860-a3b8hyyr	2703	6	)	)	-RRB-
cord-006860-a3b8hyyr	2703	7	.	.	.
cord-006860-a3b8hyyr	2704	1	J824	J824	NNP
cord-006860-a3b8hyyr	2704	2	and	and	CC
cord-006860-a3b8hyyr	2704	3	J861	J861	NNP
cord-006860-a3b8hyyr	2704	4	most	most	RBS
cord-006860-a3b8hyyr	2704	5	effectively	effectively	RB
cord-006860-a3b8hyyr	2704	6	increased	increase	VBD
cord-006860-a3b8hyyr	2704	7	the	the	DT
cord-006860-a3b8hyyr	2704	8	ELAM	ELAM	NNP
cord-006860-a3b8hyyr	2704	9	-	-	HYPH
cord-006860-a3b8hyyr	2704	10	t	t	NNP
cord-006860-a3b8hyyr	2704	11	induction	induction	NN
cord-006860-a3b8hyyr	2704	12	(	(	-LRB-
cord-006860-a3b8hyyr	2704	13	100/~M	100/~m	CD
cord-006860-a3b8hyyr	2704	14	:	:	:
cord-006860-a3b8hyyr	2704	15	85	85	CD
cord-006860-a3b8hyyr	2704	16	%	%	NN
cord-006860-a3b8hyyr	2704	17	and	and	CC
cord-006860-a3b8hyyr	2704	18	62	62	CD
cord-006860-a3b8hyyr	2704	19	%	%	NN
cord-006860-a3b8hyyr	2704	20	,	,	,
cord-006860-a3b8hyyr	2704	21	respectively	respectively	RB
cord-006860-a3b8hyyr	2704	22	)	)	-RRB-
cord-006860-a3b8hyyr	2704	23	.	.	.
cord-006860-a3b8hyyr	2705	1	The	the	DT
cord-006860-a3b8hyyr	2705	2	results	result	NNS
cord-006860-a3b8hyyr	2705	3	confirm	confirm	VBP
cord-006860-a3b8hyyr	2705	4	that	that	IN
cord-006860-a3b8hyyr	2705	5	antioxidant	antioxidant	JJ
cord-006860-a3b8hyyr	2705	6	-	-	HYPH
cord-006860-a3b8hyyr	2705	7	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	2705	8	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	2705	9	play	play	VBP
cord-006860-a3b8hyyr	2705	10	a	a	DT
cord-006860-a3b8hyyr	2705	11	role	role	NN
cord-006860-a3b8hyyr	2705	12	in	in	IN
cord-006860-a3b8hyyr	2705	13	TNFct	TNFct	NNP
cord-006860-a3b8hyyr	2705	14	-	-	HYPH
cord-006860-a3b8hyyr	2705	15	induced	induce	VBN
cord-006860-a3b8hyyr	2705	16	AM	am	NN
cord-006860-a3b8hyyr	2705	17	upregulation	upregulation	NN
cord-006860-a3b8hyyr	2705	18	.	.	.
cord-006860-a3b8hyyr	2706	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	2706	2	is	be	VBZ
cord-006860-a3b8hyyr	2706	3	suggested	suggest	VBN
cord-006860-a3b8hyyr	2706	4	that	that	IN
cord-006860-a3b8hyyr	2706	5	ICAM-1-and	ICAM-1-and	``
cord-006860-a3b8hyyr	2706	6	VCAM	VCAM	NNP
cord-006860-a3b8hyyr	2706	7	-	-	HYPH
cord-006860-a3b8hyyr	2706	8	l	l	NN
cord-006860-a3b8hyyr	2706	9	-	-	HYPH
cord-006860-a3b8hyyr	2706	10	expression	expression	NN
cord-006860-a3b8hyyr	2706	11	is	be	VBZ
cord-006860-a3b8hyyr	2706	12	regulated	regulate	VBN
cord-006860-a3b8hyyr	2706	13	differently	differently	RB
cord-006860-a3b8hyyr	2706	14	from	from	IN
cord-006860-a3b8hyyr	2706	15	ELAM	ELAM	NNP
cord-006860-a3b8hyyr	2706	16	-	-	HYPH
cord-006860-a3b8hyyr	2706	17	I.	I.	NNP
cord-006860-a3b8hyyr	2707	1	The	the	DT
cord-006860-a3b8hyyr	2707	2	diversity	diversity	NN
cord-006860-a3b8hyyr	2707	3	of	of	IN
cord-006860-a3b8hyyr	2707	4	antioxidant	antioxidant	JJ
cord-006860-a3b8hyyr	2707	5	effects	effect	NNS
cord-006860-a3b8hyyr	2707	6	might	may	MD
cord-006860-a3b8hyyr	2707	7	be	be	VB
cord-006860-a3b8hyyr	2707	8	due	due	JJ
cord-006860-a3b8hyyr	2707	9	to	to	IN
cord-006860-a3b8hyyr	2707	10	distinct	distinct	JJ
cord-006860-a3b8hyyr	2707	11	levels	level	NNS
cord-006860-a3b8hyyr	2707	12	of	of	IN
cord-006860-a3b8hyyr	2707	13	redox	redox	JJ
cord-006860-a3b8hyyr	2707	14	control	control	NN
cord-006860-a3b8hyyr	2707	15	of	of	IN
cord-006860-a3b8hyyr	2707	16	transcription	transcription	NN
cord-006860-a3b8hyyr	2707	17	with	with	IN
cord-006860-a3b8hyyr	2707	18	an	an	DT
cord-006860-a3b8hyyr	2707	19	antioxidant	antioxidant	NN
cord-006860-a3b8hyyr	2707	20	-	-	HYPH
cord-006860-a3b8hyyr	2707	21	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	2707	22	and	and	CC
cord-006860-a3b8hyyr	2707	23	an	an	DT
cord-006860-a3b8hyyr	2707	24	antioxidant	antioxidant	NN
cord-006860-a3b8hyyr	2707	25	-	-	HYPH
cord-006860-a3b8hyyr	2707	26	promoted	promote	VBN
cord-006860-a3b8hyyr	2707	27	step	step	NN
cord-006860-a3b8hyyr	2707	28	.	.	.
cord-006860-a3b8hyyr	2708	1	Heamophiliacs	Heamophiliacs	NNP
cord-006860-a3b8hyyr	2708	2	who	who	WP
cord-006860-a3b8hyyr	2708	3	continue	continue	VBP
cord-006860-a3b8hyyr	2708	4	to	to	TO
cord-006860-a3b8hyyr	2708	5	produce	produce	VB
cord-006860-a3b8hyyr	2708	6	tilers	tiler	NNS
cord-006860-a3b8hyyr	2708	7	of	of	IN
cord-006860-a3b8hyyr	2708	8	F.V11I	f.v11i	CD
cord-006860-a3b8hyyr	2708	9	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2708	10	no	no	DT
cord-006860-a3b8hyyr	2708	11	higher	high	JJR
cord-006860-a3b8hyyr	2708	12	than	than	IN
cord-006860-a3b8hyyr	2708	13	5	5	CD
cord-006860-a3b8hyyr	2708	14	to	to	TO
cord-006860-a3b8hyyr	2708	15	10	10	CD
cord-006860-a3b8hyyr	2708	16	Bethesda	Bethesda	NNP
cord-006860-a3b8hyyr	2708	17	Units	Units	NNPS
cord-006860-a3b8hyyr	2708	18	(	(	-LRB-
cord-006860-a3b8hyyr	2708	19	BU	BU	NNP
cord-006860-a3b8hyyr	2708	20	)	)	-RRB-
cord-006860-a3b8hyyr	2708	21	when	when	WRB
cord-006860-a3b8hyyr	2708	22	given	give	VBN
cord-006860-a3b8hyyr	2708	23	continuous	continuous	JJ
cord-006860-a3b8hyyr	2708	24	F	f	NN
cord-006860-a3b8hyyr	2708	25	,	,	,
cord-006860-a3b8hyyr	2708	26	VIII	VIII	NNP
cord-006860-a3b8hyyr	2708	27	replacement	replacement	NN
cord-006860-a3b8hyyr	2708	28	therapy	therapy	NN
cord-006860-a3b8hyyr	2708	29	are	be	VBP
cord-006860-a3b8hyyr	2708	30	classified	classify	VBN
cord-006860-a3b8hyyr	2708	31	as	as	IN
cord-006860-a3b8hyyr	2708	32	low	low	JJ
cord-006860-a3b8hyyr	2708	33	responders	responder	NNS
cord-006860-a3b8hyyr	2708	34	.	.	.
cord-006860-a3b8hyyr	2709	1	Studies	study	NNS
cord-006860-a3b8hyyr	2709	2	carried	carry	VBD
cord-006860-a3b8hyyr	2709	3	out	out	RP
cord-006860-a3b8hyyr	2709	4	on	on	IN
cord-006860-a3b8hyyr	2709	5	low	low	JJ
cord-006860-a3b8hyyr	2709	6	responders	responder	NNS
cord-006860-a3b8hyyr	2709	7	to	to	TO
cord-006860-a3b8hyyr	2709	8	assess	assess	VB
cord-006860-a3b8hyyr	2709	9	the	the	DT
cord-006860-a3b8hyyr	2709	10	effect	effect	NN
cord-006860-a3b8hyyr	2709	11	of	of	IN
cord-006860-a3b8hyyr	2709	12	immune	immune	JJ
cord-006860-a3b8hyyr	2709	13	tole	tole	NNP
cord-006860-a3b8hyyr	2709	14	~	~	NFP
cord-006860-a3b8hyyr	2709	15	lcc	lcc	NNP
cord-006860-a3b8hyyr	2709	16	therapy	therapy	NNP
cord-006860-a3b8hyyr	2709	17	fliT	fliT	NNP
cord-006860-a3b8hyyr	2709	18	)	)	-RRB-
cord-006860-a3b8hyyr	2709	19	in	in	IN
cord-006860-a3b8hyyr	2709	20	these	these	DT
cord-006860-a3b8hyyr	2709	21	patients	patient	NNS
cord-006860-a3b8hyyr	2709	22	.	.	.
cord-006860-a3b8hyyr	2710	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	2710	2	was	be	VBD
cord-006860-a3b8hyyr	2710	3	found	find	VBN
cord-006860-a3b8hyyr	2710	4	that	that	IN
cord-006860-a3b8hyyr	2710	5	elimination	elimination	NN
cord-006860-a3b8hyyr	2710	6	ofiahibitors	ofiahibitor	NNS
cord-006860-a3b8hyyr	2710	7	in	in	IN
cord-006860-a3b8hyyr	2710	8	low	low	JJ
cord-006860-a3b8hyyr	2710	9	responders	responder	NNS
cord-006860-a3b8hyyr	2710	10	could	could	MD
cord-006860-a3b8hyyr	2710	11	be	be	VB
cord-006860-a3b8hyyr	2710	12	achieved	achieve	VBN
cord-006860-a3b8hyyr	2710	13	using	use	VBG
cord-006860-a3b8hyyr	2710	14	F.VLII	F.VLII	NNP
cord-006860-a3b8hyyr	2710	15	at	at	IN
cord-006860-a3b8hyyr	2710	16	20	20	CD
cord-006860-a3b8hyyr	2710	17	to	to	IN
cord-006860-a3b8hyyr	2710	18	tOO	too	RB
cord-006860-a3b8hyyr	2710	19	U	U	NNP
cord-006860-a3b8hyyr	2710	20	/	/	SYM
cord-006860-a3b8hyyr	2710	21	kg	kg	NNS
cord-006860-a3b8hyyr	2710	22	given	give	VBN
cord-006860-a3b8hyyr	2710	23	every	every	DT
cord-006860-a3b8hyyr	2710	24	2	2	CD
cord-006860-a3b8hyyr	2710	25	to	to	TO
cord-006860-a3b8hyyr	2710	26	3	3	CD
cord-006860-a3b8hyyr	2710	27	days	day	NNS
cord-006860-a3b8hyyr	2710	28	over	over	IN
cord-006860-a3b8hyyr	2710	29	a	a	DT
cord-006860-a3b8hyyr	2710	30	period	period	NN
cord-006860-a3b8hyyr	2710	31	of	of	IN
cord-006860-a3b8hyyr	2710	32	6	6	CD
cord-006860-a3b8hyyr	2710	33	weeks	week	NNS
cord-006860-a3b8hyyr	2710	34	.	.	.
cord-006860-a3b8hyyr	2711	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2711	2	consider	consider	VBP
cord-006860-a3b8hyyr	2711	3	that	that	IN
cord-006860-a3b8hyyr	2711	4	1TT	1TT	NNP
cord-006860-a3b8hyyr	2711	5	is	be	VBZ
cord-006860-a3b8hyyr	2711	6	justified	justify	VBN
cord-006860-a3b8hyyr	2711	7	in	in	IN
cord-006860-a3b8hyyr	2711	8	this	this	DT
cord-006860-a3b8hyyr	2711	9	group	group	NN
cord-006860-a3b8hyyr	2711	10	of	of	IN
cord-006860-a3b8hyyr	2711	11	patients	patient	NNS
cord-006860-a3b8hyyr	2711	12	.	.	.
cord-006860-a3b8hyyr	2712	1	prevents	prevent	VBZ
cord-006860-a3b8hyyr	2712	2	rebooster	rebooster	NN
cord-006860-a3b8hyyr	2712	3	effects	effect	NNS
cord-006860-a3b8hyyr	2712	4	and	and	CC
cord-006860-a3b8hyyr	2712	5	reduces	reduce	VBZ
cord-006860-a3b8hyyr	2712	6	elimimfion	elimimfion	NN
cord-006860-a3b8hyyr	2712	7	time	time	NN
cord-006860-a3b8hyyr	2712	8	of	of	IN
cord-006860-a3b8hyyr	2712	9	F.VIII	f.viii	CD
cord-006860-a3b8hyyr	2712	10	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2712	11	.	.	.
cord-006860-a3b8hyyr	2713	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	2713	2	also	also	RB
cord-006860-a3b8hyyr	2713	3	reduces	reduce	VBZ
cord-006860-a3b8hyyr	2713	4	the	the	DT
cord-006860-a3b8hyyr	2713	5	enhanced	enhanced	JJ
cord-006860-a3b8hyyr	2713	6	mortality	mortality	NN
cord-006860-a3b8hyyr	2713	7	in	in	IN
cord-006860-a3b8hyyr	2713	8	patients	patient	NNS
cord-006860-a3b8hyyr	2713	9	with	with	IN
cord-006860-a3b8hyyr	2713	10	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2713	11	and	and	CC
cord-006860-a3b8hyyr	2713	12	has	have	VBZ
cord-006860-a3b8hyyr	2713	13	been	be	VBN
cord-006860-a3b8hyyr	2713	14	shown	show	VBN
cord-006860-a3b8hyyr	2713	15	to	to	TO
cord-006860-a3b8hyyr	2713	16	be	be	VB
cord-006860-a3b8hyyr	2713	17	cost	cost	NN
cord-006860-a3b8hyyr	2713	18	-	-	HYPH
cord-006860-a3b8hyyr	2713	19	effective	effective	JJ
cord-006860-a3b8hyyr	2713	20	.	.	.
cord-006860-a3b8hyyr	2714	1	In	in	IN
cord-006860-a3b8hyyr	2714	2	view	view	NN
cord-006860-a3b8hyyr	2714	3	of	of	IN
cord-006860-a3b8hyyr	2714	4	the	the	DT
cord-006860-a3b8hyyr	2714	5	improved	improved	JJ
cord-006860-a3b8hyyr	2714	6	prognosis	prognosis	NN
cord-006860-a3b8hyyr	2714	7	,	,	,
cord-006860-a3b8hyyr	2714	8	we	-PRON-	PRP
cord-006860-a3b8hyyr	2714	9	recontmend	recontmend	VBP
cord-006860-a3b8hyyr	2714	10	starting	start	VBG
cord-006860-a3b8hyyr	2714	11	ITT	ITT	NNP
cord-006860-a3b8hyyr	2714	12	in	in	IN
cord-006860-a3b8hyyr	2714	13	low	low	JJ
cord-006860-a3b8hyyr	2714	14	respor	respor	NN
cord-006860-a3b8hyyr	2714	15	,	,	,
cord-006860-a3b8hyyr	2714	16	ders	ders	NNP
cord-006860-a3b8hyyr	2714	17	soon	soon	RB
cord-006860-a3b8hyyr	2714	18	after	after	IN
cord-006860-a3b8hyyr	2714	19	the	the	DT
cord-006860-a3b8hyyr	2714	20	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	2714	21	has	have	VBZ
cord-006860-a3b8hyyr	2714	22	been	be	VBN
cord-006860-a3b8hyyr	2714	23	made	make	VBN
cord-006860-a3b8hyyr	2714	24	in	in	IN
cord-006860-a3b8hyyr	2714	25	order	order	NN
cord-006860-a3b8hyyr	2714	26	to	to	TO
cord-006860-a3b8hyyr	2714	27	minimize	minimize	VB
cord-006860-a3b8hyyr	2714	28	F.VIll	F.VIll	NNP
cord-006860-a3b8hyyr	2714	29	exposure	exposure	NN
cord-006860-a3b8hyyr	2714	30	before	before	IN
cord-006860-a3b8hyyr	2714	31	isfi.tiating	isfi.tiate	VBG
cord-006860-a3b8hyyr	2714	32	El	El	NNP
cord-006860-a3b8hyyr	2714	33	'	'	''
cord-006860-a3b8hyyr	2714	34	.	.	.
cord-006860-a3b8hyyr	2715	1	ITr	itr	RB
cord-006860-a3b8hyyr	2715	2	in	in	IN
cord-006860-a3b8hyyr	2715	3	low	low	JJ
cord-006860-a3b8hyyr	2715	4	responders	responder	NNS
cord-006860-a3b8hyyr	2715	5	has	have	VBZ
cord-006860-a3b8hyyr	2715	6	a	a	DT
cord-006860-a3b8hyyr	2715	7	better	well	JJR
cord-006860-a3b8hyyr	2715	8	success	success	NN
cord-006860-a3b8hyyr	2715	9	rate	rate	NN
cord-006860-a3b8hyyr	2715	10	an	an	DT
cord-006860-a3b8hyyr	2715	11	.	.	.
cord-006860-a3b8hyyr	2716	1	,	,	,
cord-006860-a3b8hyyr	2716	2	d	d	NNP
cord-006860-a3b8hyyr	2716	3	requires	require	VBZ
cord-006860-a3b8hyyr	2716	4	shorter	short	JJR
cord-006860-a3b8hyyr	2716	5	U'eatment	u'eatment	CD
cord-006860-a3b8hyyr	2716	6	than	than	IN
cord-006860-a3b8hyyr	2716	7	ITT	ITT	NNP
cord-006860-a3b8hyyr	2716	8	in	in	IN
cord-006860-a3b8hyyr	2716	9	high	high	JJ
cord-006860-a3b8hyyr	2716	10	responders	responder	NNS
cord-006860-a3b8hyyr	2716	11	.	.	.
cord-006860-a3b8hyyr	2717	1	W.Schramm	W.Schramm	NNP
cord-006860-a3b8hyyr	2717	2	,	,	,
cord-006860-a3b8hyyr	2717	3	Med	Med	NNP
cord-006860-a3b8hyyr	2717	4	.	.	.
cord-006860-a3b8hyyr	2718	1	Klin~	Klin~	NNP
cord-006860-a3b8hyyr	2718	2	,	,	,
cord-006860-a3b8hyyr	2718	3	Innenstadt	Innenstadt	NNP
cord-006860-a3b8hyyr	2718	4	,	,	,
cord-006860-a3b8hyyr	2718	5	LMU	LMU	NNP
cord-006860-a3b8hyyr	2718	6	,	,	,
cord-006860-a3b8hyyr	2719	1	Mfinchen	Mfinchen	NNP
cord-006860-a3b8hyyr	2719	2	Following	follow	VBG
cord-006860-a3b8hyyr	2720	1	replacement	replacement	NN
cord-006860-a3b8hyyr	2720	2	therapie~	therapie~	NNP
cord-006860-a3b8hyyr	2720	3	in	in	IN
cord-006860-a3b8hyyr	2720	4	hemphilm	hemphilm	NNP
cord-006860-a3b8hyyr	2720	5	t_be	t_be	NN
cord-006860-a3b8hyyr	2720	6	developmem	developmem	NNP
cord-006860-a3b8hyyr	2720	7	of	of	IN
cord-006860-a3b8hyyr	2720	8	inhibimrs	inhibimrs	NNP
cord-006860-a3b8hyyr	2720	9	to	to	IN
cord-006860-a3b8hyyr	2720	10	the	the	DT
cord-006860-a3b8hyyr	2720	11	p*ficat	p*ficat	NNP
cord-006860-a3b8hyyr	2720	12	's	's	POS
cord-006860-a3b8hyyr	2720	13	deficient	deficient	JJ
cord-006860-a3b8hyyr	2720	14	factor	factor	NN
cord-006860-a3b8hyyr	2720	15	is	be	VBZ
cord-006860-a3b8hyyr	2720	16	the	the	DT
cord-006860-a3b8hyyr	2720	17	most	most	RBS
cord-006860-a3b8hyyr	2720	18	serious	serious	JJ
cord-006860-a3b8hyyr	2720	19	sequelae	sequela	NNS
cord-006860-a3b8hyyr	2720	20	.	.	.
cord-006860-a3b8hyyr	2721	1	The	the	DT
cord-006860-a3b8hyyr	2721	2	incidence	incidence	NN
cord-006860-a3b8hyyr	2721	3	of	of	IN
cord-006860-a3b8hyyr	2721	4	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2721	5	varies	vary	VBZ
cord-006860-a3b8hyyr	2721	6	between	between	IN
cord-006860-a3b8hyyr	2721	7	15	15	CD
cord-006860-a3b8hyyr	2721	8	and	and	CC
cord-006860-a3b8hyyr	2721	9	35	35	CD
cord-006860-a3b8hyyr	2721	10	%	%	NN
cord-006860-a3b8hyyr	2721	11	of	of	IN
cord-006860-a3b8hyyr	2721	12	persons	person	NNS
cord-006860-a3b8hyyr	2721	13	with	with	IN
cord-006860-a3b8hyyr	2721	14	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2721	15	A.	A.	NNP
cord-006860-a3b8hyyr	2721	16	Inhibitor	Inhibitor	NNP
cord-006860-a3b8hyyr	2721	17	develop	develop	VB
cord-006860-a3b8hyyr	2721	18	,	,	,
cord-006860-a3b8hyyr	2721	19	mostly	mostly	RB
cord-006860-a3b8hyyr	2721	20	in	in	IN
cord-006860-a3b8hyyr	2721	21	paticm~	paticm~	NNP
cord-006860-a3b8hyyr	2721	22	with	with	IN
cord-006860-a3b8hyyr	2721	23	sovere	sovere	FW
cord-006860-a3b8hyyr	2721	24	bemoph	bemoph	NNP
cord-006860-a3b8hyyr	2722	1	/lia	/lia	NFP
cord-006860-a3b8hyyr	2722	2	A	a	DT
cord-006860-a3b8hyyr	2722	3	,	,	,
cord-006860-a3b8hyyr	2722	4	early	early	RB
cord-006860-a3b8hyyr	2722	5	in	in	IN
cord-006860-a3b8hyyr	2722	6	Life	Life	NNP
cord-006860-a3b8hyyr	2722	7	and	and	CC
cord-006860-a3b8hyyr	2722	8	afmr	afmr	NNP
cord-006860-a3b8hyyr	2722	9	few	few	JJ
cord-006860-a3b8hyyr	2722	10	exposure	exposure	NN
cord-006860-a3b8hyyr	2722	11	days	day	NNS
cord-006860-a3b8hyyr	2722	12	(	(	-LRB-
cord-006860-a3b8hyyr	2722	13	9	9	CD
cord-006860-a3b8hyyr	2722	14	-12	-12	NN
cord-006860-a3b8hyyr	2722	15	days	day	NNS
cord-006860-a3b8hyyr	2722	16	)	)	-RRB-
cord-006860-a3b8hyyr	2722	17	.	.	.
cord-006860-a3b8hyyr	2723	1	Using	use	VBG
cord-006860-a3b8hyyr	2723	2	the	the	DT
cord-006860-a3b8hyyr	2723	3	Bethesdamethod	Bethesdamethod	NNP
cord-006860-a3b8hyyr	2723	4	the	the	DT
cord-006860-a3b8hyyr	2723	5	inh	inh	NNP
cord-006860-a3b8hyyr	2723	6	~	~	NFP
cord-006860-a3b8hyyr	2723	7	itom	itom	NN
cord-006860-a3b8hyyr	2723	8	can	can	MD
cord-006860-a3b8hyyr	2723	9	be	be	VB
cord-006860-a3b8hyyr	2723	10	derided	deride	VBN
cord-006860-a3b8hyyr	2723	11	in	in	IN
cord-006860-a3b8hyyr	2723	12	low	low	JJ
cord-006860-a3b8hyyr	2723	13	(	(	-LRB-
cord-006860-a3b8hyyr	2723	14	<	<	NNP
cord-006860-a3b8hyyr	2723	15	5	5	CD
cord-006860-a3b8hyyr	2723	16	BU	BU	NNP
cord-006860-a3b8hyyr	2723	17	)	)	-RRB-
cord-006860-a3b8hyyr	2723	18	and	and	CC
cord-006860-a3b8hyyr	2723	19	high	high	JJ
cord-006860-a3b8hyyr	2723	20	msponder	msponder	NN
cord-006860-a3b8hyyr	2723	21	(	(	-LRB-
cord-006860-a3b8hyyr	2723	22	>	>	NFP
cord-006860-a3b8hyyr	2723	23	5	5	CD
cord-006860-a3b8hyyr	2723	24	BU	BU	NNP
cord-006860-a3b8hyyr	2723	25	)	)	-RRB-
cord-006860-a3b8hyyr	2724	1	Hemopb	Hemopb	NNP
cord-006860-a3b8hyyr	2724	2	~	~	NFP
cord-006860-a3b8hyyr	2724	3	iacs	iac	NNS
cord-006860-a3b8hyyr	2724	4	with	with	IN
cord-006860-a3b8hyyr	2724	5	high	high	JJ
cord-006860-a3b8hyyr	2724	6	fitcrs	fitcr	NNS
cord-006860-a3b8hyyr	2724	7	have	have	VBP
cord-006860-a3b8hyyr	2724	8	~ually	~ually	RB
cord-006860-a3b8hyyr	2724	9	serious	serious	JJ
cord-006860-a3b8hyyr	2724	10	~	~	NFP
cord-006860-a3b8hyyr	2724	11	problems	problem	NNS
cord-006860-a3b8hyyr	2724	12	.	.	.
cord-006860-a3b8hyyr	2725	1	They	-PRON-	PRP
cord-006860-a3b8hyyr	2725	2	are	be	VBP
cord-006860-a3b8hyyr	2725	3	resistent	resistent	JJ
cord-006860-a3b8hyyr	2725	4	to	to	IN
cord-006860-a3b8hyyr	2725	5	mg,,flary	mg,,flary	NNP
cord-006860-a3b8hyyr	2725	6	replacement	replacement	NN
cord-006860-a3b8hyyr	2725	7	therapy	therapy	NN
cord-006860-a3b8hyyr	2725	8	,	,	,
cord-006860-a3b8hyyr	2725	9	The	the	DT
cord-006860-a3b8hyyr	2725	10	~	~	NFP
cord-006860-a3b8hyyr	2725	11	goal	goal	NN
cord-006860-a3b8hyyr	2725	12	in	in	IN
cord-006860-a3b8hyyr	2725	13	the	the	DT
cord-006860-a3b8hyyr	2725	14	treawnent	treawnent	NN
cord-006860-a3b8hyyr	2725	15	is	be	VBZ
cord-006860-a3b8hyyr	2725	16	to	to	TO
cord-006860-a3b8hyyr	2725	17	control	control	VB
cord-006860-a3b8hyyr	2725	18	severn	severn	NNP
cord-006860-a3b8hyyr	2725	19	acum	acum	NNP
cord-006860-a3b8hyyr	2725	20	bleedin~	bleedin~	NNP
cord-006860-a3b8hyyr	2725	21	and	and	CC
cord-006860-a3b8hyyr	2725	22	to	to	TO
cord-006860-a3b8hyyr	2725	23	eradicate	eradicate	VB
cord-006860-a3b8hyyr	2725	24	the	the	DT
cord-006860-a3b8hyyr	2725	25	inlu'bitor	inlu'bitor	NN
cord-006860-a3b8hyyr	2725	26	perrmnanfly	perrmnanfly	NN
cord-006860-a3b8hyyr	2725	27	and	and	CC
cord-006860-a3b8hyyr	2725	28	to	to	TO
cord-006860-a3b8hyyr	2725	29	induce	induce	VB
cord-006860-a3b8hyyr	2725	30	tolea'ance	tolea'ance	NN
cord-006860-a3b8hyyr	2725	31	.	.	.
cord-006860-a3b8hyyr	2726	1	In	in	IN
cord-006860-a3b8hyyr	2726	2	the	the	DT
cord-006860-a3b8hyyr	2726	3	tream'tmt	tream'tmt	NN
cord-006860-a3b8hyyr	2726	4	of	of	IN
cord-006860-a3b8hyyr	2726	5	acute	acute	JJ
cord-006860-a3b8hyyr	2726	6	blcedings	blceding	NNS
cord-006860-a3b8hyyr	2726	7	in	in	IN
cord-006860-a3b8hyyr	2726	8	patients	patient	NNS
cord-006860-a3b8hyyr	2726	9	with	with	IN
cord-006860-a3b8hyyr	2726	10	hlhibitors	hlhibitors	NNP
cord-006860-a3b8hyyr	2726	11	factor	factor	NN
cord-006860-a3b8hyyr	2726	12	VIII	VIII	NNP
cord-006860-a3b8hyyr	2726	13	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2726	14	bypassing	bypass	VBG
cord-006860-a3b8hyyr	2726	15	ag	ag	NNP
cord-006860-a3b8hyyr	2727	1	~ts	~ts	NNP
cord-006860-a3b8hyyr	2727	2	like	like	IN
cord-006860-a3b8hyyr	2727	3	activated	activate	VBN
cord-006860-a3b8hyyr	2727	4	prothro~	prothro~	NNP
cord-006860-a3b8hyyr	2727	5	complex	complex	JJ
cord-006860-a3b8hyyr	2727	6	concenuxtes	concenuxte	NNS
cord-006860-a3b8hyyr	2727	7	(	(	-LRB-
cord-006860-a3b8hyyr	2727	8	FEIBA	FEIBA	NNP
cord-006860-a3b8hyyr	2727	9	)	)	-RRB-
cord-006860-a3b8hyyr	2727	10	or	or	CC
cord-006860-a3b8hyyr	2727	11	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	2727	12	complex	complex	NN
cord-006860-a3b8hyyr	2727	13	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	2727	14	(	(	-LRB-
cord-006860-a3b8hyyr	2727	15	PCC	PCC	NNP
cord-006860-a3b8hyyr	2727	16	)	)	-RRB-
cord-006860-a3b8hyyr	2727	17	arc	arc	NNP
cord-006860-a3b8hyyr	2727	18	mostly	mostly	RB
cord-006860-a3b8hyyr	2727	19	used	use	VBN
cord-006860-a3b8hyyr	2727	20	.	.	.
cord-006860-a3b8hyyr	2728	1	The	the	DT
cord-006860-a3b8hyyr	2728	2	meehani	meehani	NNS
cord-006860-a3b8hyyr	2728	3	~	~	NNP
cord-006860-a3b8hyyr	2728	4	n	n	NNP
cord-006860-a3b8hyyr	2728	5	of	of	IN
cord-006860-a3b8hyyr	2728	6	aefiou	aefiou	NNP
cord-006860-a3b8hyyr	2728	7	of	of	IN
cord-006860-a3b8hyyr	2728	8	these	these	DT
cord-006860-a3b8hyyr	2728	9	s	s	NNP
cord-006860-a3b8hyyr	2728	10	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	2728	11	is	be	VBZ
cord-006860-a3b8hyyr	2728	12	net	net	JJ
cord-006860-a3b8hyyr	2728	13	fully	fully	RB
cord-006860-a3b8hyyr	2728	14	investigated	investigate	VBN
cord-006860-a3b8hyyr	2728	15	.	.	.
cord-006860-a3b8hyyr	2729	1	Their	-PRON-	PRP$
cord-006860-a3b8hyyr	2729	2	effect	effect	NN
cord-006860-a3b8hyyr	2729	3	is	be	VBZ
cord-006860-a3b8hyyr	2729	4	usually	usually	RB
cord-006860-a3b8hyyr	2729	5	related	relate	VBN
cord-006860-a3b8hyyr	2729	6	to	to	IN
cord-006860-a3b8hyyr	2729	7	the	the	DT
cord-006860-a3b8hyyr	2729	8	high	high	JJ
cord-006860-a3b8hyyr	2729	9	coment	coment	NN
cord-006860-a3b8hyyr	2729	10	of	of	IN
cord-006860-a3b8hyyr	2729	11	activated	activate	VBN
cord-006860-a3b8hyyr	2729	12	clotting	clotting	NN
cord-006860-a3b8hyyr	2729	13	factors	factor	NNS
cord-006860-a3b8hyyr	2729	14	~d	~d	NNP
cord-006860-a3b8hyyr	2729	15	phosphoUpids	phosphoupid	NNS
cord-006860-a3b8hyyr	2729	16	.	.	.
cord-006860-a3b8hyyr	2730	1	Since	since	IN
cord-006860-a3b8hyyr	2730	2	some	some	DT
cord-006860-a3b8hyyr	2730	3	years	year	NNS
cord-006860-a3b8hyyr	2730	4	acdwated	acdwate	VBD
cord-006860-a3b8hyyr	2730	5	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	2730	6	Factor	Factor	NNP
cord-006860-a3b8hyyr	2730	7	VII	VII	NNP
cord-006860-a3b8hyyr	2730	8	(	(	-LRB-
cord-006860-a3b8hyyr	2730	9	F	F	NNP
cord-006860-a3b8hyyr	2730	10	VII	VII	NNP
cord-006860-a3b8hyyr	2730	11	a	a	DT
cord-006860-a3b8hyyr	2730	12	)	)	-RRB-
cord-006860-a3b8hyyr	2730	13	is	be	VBZ
cord-006860-a3b8hyyr	2730	14	used	use	VBN
cord-006860-a3b8hyyr	2730	15	to	to	TO
cord-006860-a3b8hyyr	2730	16	treat	treat	VB
cord-006860-a3b8hyyr	2730	17	patients	patient	NNS
cord-006860-a3b8hyyr	2730	18	with	with	IN
cord-006860-a3b8hyyr	2730	19	inl'dbitocs	inl'dbitocs	NNP
cord-006860-a3b8hyyr	2730	20	successfully	successfully	RB
cord-006860-a3b8hyyr	2730	21	in	in	IN
cord-006860-a3b8hyyr	2730	22	several	several	JJ
cord-006860-a3b8hyyr	2730	23	clinical	clinical	JJ
cord-006860-a3b8hyyr	2730	24	situations	situation	NNS
cord-006860-a3b8hyyr	2730	25	including	include	VBG
cord-006860-a3b8hyyr	2730	26	surgery	surgery	NN
cord-006860-a3b8hyyr	2730	27	.	.	.
cord-006860-a3b8hyyr	2731	1	In	in	IN
cord-006860-a3b8hyyr	2731	2	addition	addition	NN
cord-006860-a3b8hyyr	2731	3	porcine	porcine	JJ
cord-006860-a3b8hyyr	2731	4	factor	factor	NN
cord-006860-a3b8hyyr	2731	5	VII1	VII1	NNP
cord-006860-a3b8hyyr	2731	6	is	be	VBZ
cord-006860-a3b8hyyr	2731	7	widely	widely	RB
cord-006860-a3b8hyyr	2731	8	used	use	VBN
cord-006860-a3b8hyyr	2731	9	in	in	IN
cord-006860-a3b8hyyr	2731	10	particular	particular	JJ
cord-006860-a3b8hyyr	2731	11	in	in	IN
cord-006860-a3b8hyyr	2731	12	the	the	DT
cord-006860-a3b8hyyr	2731	13	UK	UK	NNP
cord-006860-a3b8hyyr	2731	14	for	for	IN
cord-006860-a3b8hyyr	2731	15	the	the	DT
cord-006860-a3b8hyyr	2731	16	treatment	treatment	NN
cord-006860-a3b8hyyr	2731	17	of	of	IN
cord-006860-a3b8hyyr	2731	18	factor	factor	NN
cord-006860-a3b8hyyr	2731	19	V].II	V].II	HYPH
cord-006860-a3b8hyyr	2731	20	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2731	21	patients	patient	NNS
cord-006860-a3b8hyyr	2731	22	and	and	CC
cord-006860-a3b8hyyr	2731	23	could	could	MD
cord-006860-a3b8hyyr	2731	24	demonstrade	demonstrade	VB
cord-006860-a3b8hyyr	2731	25	good	good	JJ
cord-006860-a3b8hyyr	2731	26	clir3cal	clir3cal	JJ
cord-006860-a3b8hyyr	2731	27	results	result	NNS
cord-006860-a3b8hyyr	2731	28	,	,	,
cord-006860-a3b8hyyr	2732	1	In	in	IN
cord-006860-a3b8hyyr	2732	2	case	case	NN
cord-006860-a3b8hyyr	2732	3	of	of	IN
cord-006860-a3b8hyyr	2732	4	life	life	NN
cord-006860-a3b8hyyr	2732	5	threatening	threaten	VBG
cord-006860-a3b8hyyr	2732	6	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	2732	7	a	a	DT
cord-006860-a3b8hyyr	2732	8	temporary	temporary	JJ
cord-006860-a3b8hyyr	2732	9	reducfic~	reducfic~	NN
cord-006860-a3b8hyyr	2732	10	of	of	IN
cord-006860-a3b8hyyr	2732	11	inhihitors	inhihitor	NNS
cord-006860-a3b8hyyr	2732	12	could	could	MD
cord-006860-a3b8hyyr	2732	13	be	be	VB
cord-006860-a3b8hyyr	2732	14	.	.	.
cord-006860-a3b8hyyr	2733	1	~hieved	~hieve	VBN
cord-006860-a3b8hyyr	2733	2	by	by	IN
cord-006860-a3b8hyyr	2733	3	using	use	VBG
cord-006860-a3b8hyyr	2733	4	extem*,ivc	extem*,ivc	NNP
cord-006860-a3b8hyyr	2733	5	plasma	plasma	NN
cord-006860-a3b8hyyr	2733	6	exchange	exchange	NN
cord-006860-a3b8hyyr	2733	7	(	(	-LRB-
cord-006860-a3b8hyyr	2733	8	Protein	Protein	NNP
cord-006860-a3b8hyyr	2733	9	A	a	DT
cord-006860-a3b8hyyr	2733	10	adsorption	adsorption	NN
cord-006860-a3b8hyyr	2733	11	)	)	-RRB-
cord-006860-a3b8hyyr	2733	12	and	and	CC
cord-006860-a3b8hyyr	2733	13	immune	immune	JJ
cord-006860-a3b8hyyr	2733	14	suppression	suppression	NN
cord-006860-a3b8hyyr	2733	15	with	with	IN
cord-006860-a3b8hyyr	2733	16	cyclophosphamid	cyclophosphamid	NNP
cord-006860-a3b8hyyr	2733	17	(	(	-LRB-
cord-006860-a3b8hyyr	2733	18	~alm6	~alm6	NFP
cord-006860-a3b8hyyr	2733	19	protocol	protocol	NN
cord-006860-a3b8hyyr	2733	20	)	)	-RRB-
cord-006860-a3b8hyyr	2733	21	.	.	.
cord-006860-a3b8hyyr	2734	1	Follow	follow	VB
cord-006860-a3b8hyyr	2734	2	~	~	NFP
cord-006860-a3b8hyyr	2734	3	g	g	NN
cord-006860-a3b8hyyr	2735	1	the	the	DT
cord-006860-a3b8hyyr	2735	2	first	first	JJ
cord-006860-a3b8hyyr	2735	3	description	description	NN
cord-006860-a3b8hyyr	2735	4	by	by	IN
cord-006860-a3b8hyyr	2735	5	H.	H.	NNP
cord-006860-a3b8hyyr	2735	6	Bmc~'~mn	Bmc~'~mn	NNP
cord-006860-a3b8hyyr	2735	7	some	some	DT
cord-006860-a3b8hyyr	2735	8	modifications	modification	NNS
cord-006860-a3b8hyyr	2735	9	for	for	IN
cord-006860-a3b8hyyr	2735	10	tlm	tlm	NNP
cord-006860-a3b8hyyr	2735	11	induction	induction	NNP
cord-006860-a3b8hyyr	2735	12	of	of	IN
cord-006860-a3b8hyyr	2735	13	irmnune	irmnune	JJ
cord-006860-a3b8hyyr	2735	14	tolerance	tolerance	NN
cord-006860-a3b8hyyr	2735	15	in	in	IN
cord-006860-a3b8hyyr	2735	16	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2736	1	A	a	DT
cord-006860-a3b8hyyr	2736	2	patients	patient	NNS
cord-006860-a3b8hyyr	2736	3	have	have	VBP
cord-006860-a3b8hyyr	2736	4	~en	~en	CD
cord-006860-a3b8hyyr	2737	1	propet'ed	propet'ed	NNP
cord-006860-a3b8hyyr	2737	2	.	.	.
cord-006860-a3b8hyyr	2738	1	These	these	DT
cord-006860-a3b8hyyr	2738	2	schedule	schedule	NN
cord-006860-a3b8hyyr	2738	3	,	,	,
cord-006860-a3b8hyyr	2738	4	can	can	MD
cord-006860-a3b8hyyr	2738	5	be	be	VB
cord-006860-a3b8hyyr	2738	6	derided	deride	VBN
cord-006860-a3b8hyyr	2738	7	into	into	IN
cord-006860-a3b8hyyr	2738	8	high	high	JJ
cord-006860-a3b8hyyr	2738	9	,	,	,
cord-006860-a3b8hyyr	2738	10	intemxxfime	intemxxfime	NN
cord-006860-a3b8hyyr	2738	11	and	and	CC
cord-006860-a3b8hyyr	2738	12	low	low	JJ
cord-006860-a3b8hyyr	2738	13	dosage	dosage	NN
cord-006860-a3b8hyyr	2738	14	roglrmms	roglrmms	NN
cord-006860-a3b8hyyr	2738	15	di	di	NN
cord-006860-a3b8hyyr	2738	16	:	:	:
cord-006860-a3b8hyyr	2739	1	ffea'Jng	ffea'Jng	NFP
cord-006860-a3b8hyyr	2739	2	in	in	IN
cord-006860-a3b8hyyr	2739	3	the	the	DT
cord-006860-a3b8hyyr	2739	4	dosage	dosage	NN
cord-006860-a3b8hyyr	2739	5	of	of	IN
cord-006860-a3b8hyyr	2739	6	factor	factor	NN
cord-006860-a3b8hyyr	2739	7	VIII	VIII	NNP
cord-006860-a3b8hyyr	2739	8	infused	infuse	VBD
cord-006860-a3b8hyyr	2739	9	.	.	.
cord-006860-a3b8hyyr	2740	1	Successful	successful	JJ
cord-006860-a3b8hyyr	2740	2	rates	rate	NNS
cord-006860-a3b8hyyr	2740	3	about	about	RB
cord-006860-a3b8hyyr	2740	4	70	70	CD
cord-006860-a3b8hyyr	2740	5	to	to	TO
cord-006860-a3b8hyyr	2740	6	gO	go	VB
cord-006860-a3b8hyyr	2740	7	%	%	NN
cord-006860-a3b8hyyr	2740	8	can	can	MD
cord-006860-a3b8hyyr	2740	9	be	be	VB
cord-006860-a3b8hyyr	2740	10	obtained	obtain	VBN
cord-006860-a3b8hyyr	2740	11	with	with	IN
cord-006860-a3b8hyyr	2740	12	~	~	NFP
cord-006860-a3b8hyyr	2740	13	and	and	CC
cord-006860-a3b8hyyr	2740	14	high	high	JJ
cord-006860-a3b8hyyr	2740	15	dose	dose	NN
cord-006860-a3b8hyyr	2740	16	regimens	regimen	NNS
cord-006860-a3b8hyyr	2740	17	.	.	.
cord-006860-a3b8hyyr	2741	1	But	but	CC
cord-006860-a3b8hyyr	2741	2	is	be	VBZ
cord-006860-a3b8hyyr	2741	3	has	have	VBZ
cord-006860-a3b8hyyr	2741	4	to	to	TO
cord-006860-a3b8hyyr	2741	5	be	be	VB
cord-006860-a3b8hyyr	2741	6	co	co	VBN
cord-006860-a3b8hyyr	2741	7	~	~	CD
cord-006860-a3b8hyyr	2741	8	sidered	sidere	VBD
cord-006860-a3b8hyyr	2741	9	that	that	IN
cord-006860-a3b8hyyr	2741	10	the~	the~	CD
cord-006860-a3b8hyyr	2741	11	expensive	expensive	JJ
cord-006860-a3b8hyyr	2741	12	treA.t	trea.t	XX
cord-006860-a3b8hyyr	2741	13	~	~	NFP
cord-006860-a3b8hyyr	2741	14	nt	nt	RB
cord-006860-a3b8hyyr	2741	15	regimens	regimen	NNS
cord-006860-a3b8hyyr	2741	16	have	have	VBP
cord-006860-a3b8hyyr	2741	17	a	a	DT
cord-006860-a3b8hyyr	2741	18	great	great	JJ
cord-006860-a3b8hyyr	2741	19	physical	physical	NN
cord-006860-a3b8hyyr	2741	20	and	and	CC
cord-006860-a3b8hyyr	2741	21	p	p	NN
cord-006860-a3b8hyyr	2741	22	.syc.hosocial	.syc.hosocial	JJ
cord-006860-a3b8hyyr	2741	23	impact	impact	NN
cord-006860-a3b8hyyr	2741	24	to	to	IN
cord-006860-a3b8hyyr	2741	25	the	the	DT
cord-006860-a3b8hyyr	2741	26	benx~-li	benx~-li	NNP
cord-006860-a3b8hyyr	2741	27	~	~	NFP
cord-006860-a3b8hyyr	2741	28	s	s	NNP
cord-006860-a3b8hyyr	2741	29	and	and	CC
cord-006860-a3b8hyyr	2741	30	thch	thch	NNP
cord-006860-a3b8hyyr	2741	31	"	"	''
cord-006860-a3b8hyyr	2741	32	farm	farm	NN
cord-006860-a3b8hyyr	2741	33	~	~	NFP
cord-006860-a3b8hyyr	2741	34	e	e	NFP
cord-006860-a3b8hyyr	2741	35	&	&	CC
cord-006860-a3b8hyyr	2741	36	The	the	DT
cord-006860-a3b8hyyr	2741	37	different	different	JJ
cord-006860-a3b8hyyr	2741	38	immu~	immu~	NNP
cord-006860-a3b8hyyr	2741	39	mler	mler	NN
cord-006860-a3b8hyyr	2741	40	-	-	HYPH
cord-006860-a3b8hyyr	2741	41	a.~ze	a.~ze	CC
cord-006860-a3b8hyyr	2741	42	mg~-'~	mg~-'~	NN
cord-006860-a3b8hyyr	2741	43	predominantly	predominantly	RB
cord-006860-a3b8hyyr	2741	44	used	use	VBN
cord-006860-a3b8hyyr	2741	45	in	in	IN
cord-006860-a3b8hyyr	2741	46	high	high	JJ
cord-006860-a3b8hyyr	2741	47	rcsponder	rcsponder	NN
cord-006860-a3b8hyyr	2741	48	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2741	49	.	.	.
cord-006860-a3b8hyyr	2742	1	Most	Most	JJS
cord-006860-a3b8hyyr	2742	2	of	of	IN
cord-006860-a3b8hyyr	2742	3	the	the	DT
cord-006860-a3b8hyyr	2742	4	patients	patient	NNS
cord-006860-a3b8hyyr	2742	5	with	with	IN
cord-006860-a3b8hyyr	2742	6	low	low	JJ
cord-006860-a3b8hyyr	2742	7	concentrations	concentration	NNS
cord-006860-a3b8hyyr	2742	8	of	of	IN
cord-006860-a3b8hyyr	2742	9	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	2742	10	cm	cm	NNS
cord-006860-a3b8hyyr	2742	11	be	be	VB
cord-006860-a3b8hyyr	2742	12	managed	manage	VBN
cord-006860-a3b8hyyr	2742	13	with	with	IN
cord-006860-a3b8hyyr	2742	14	factor	factor	NN
cord-006860-a3b8hyyr	2742	15	VIII	VIII	NNP
cord-006860-a3b8hyyr	2742	16	in	in	IN
cord-006860-a3b8hyyr	2742	17	increased	increase	VBN
cord-006860-a3b8hyyr	2742	18	dosage	dosage	NN
cord-006860-a3b8hyyr	2742	19	.	.	.
cord-006860-a3b8hyyr	2743	1	This	this	DT
cord-006860-a3b8hyyr	2743	2	is	be	VBZ
cord-006860-a3b8hyyr	2743	3	in	in	IN
cord-006860-a3b8hyyr	2743	4	agreement	agreement	NN
cord-006860-a3b8hyyr	2743	5	with	with	IN
cord-006860-a3b8hyyr	2743	6	the	the	DT
cord-006860-a3b8hyyr	2743	7	consensus	consensus	NN
cord-006860-a3b8hyyr	2743	8	recorrnr	recorrnr	NNP
cord-006860-a3b8hyyr	2743	9	~	~	CD
cord-006860-a3b8hyyr	2743	10	rdadons	rdadon	NNS
cord-006860-a3b8hyyr	2743	11	for	for	IN
cord-006860-a3b8hyyr	2743	12	u'eatlncnt	u'eatlncnt	JJ
cord-006860-a3b8hyyr	2743	13	hemophiliacs	hemophiliac	NNS
cord-006860-a3b8hyyr	2743	14	in	in	IN
cord-006860-a3b8hyyr	2743	15	Germany	Germany	NNP
cord-006860-a3b8hyyr	2743	16	fi'orn	fi'orn	IN
cord-006860-a3b8hyyr	2743	17	1994	1994	CD
cord-006860-a3b8hyyr	2743	18	.	.	.
cord-006860-a3b8hyyr	2744	1	Before	before	IN
cord-006860-a3b8hyyr	2744	2	Vitamin	vitamin	NN
cord-006860-a3b8hyyr	2744	3	K(VK	K(VK	NNP
cord-006860-a3b8hyyr	2744	4	)	)	-RRB-
cord-006860-a3b8hyyr	2744	5	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2744	6	was	be	VBD
cord-006860-a3b8hyyr	2744	7	generally	generally	RB
cord-006860-a3b8hyyr	2744	8	accepted	accept	VBN
cord-006860-a3b8hyyr	2744	9	in	in	IN
cord-006860-a3b8hyyr	2744	10	Japan	Japan	NNP
cord-006860-a3b8hyyr	2744	11	,	,	,
cord-006860-a3b8hyyr	2744	12	the	the	DT
cord-006860-a3b8hyyr	2744	13	incidence	incidence	NN
cord-006860-a3b8hyyr	2744	14	of	of	IN
cord-006860-a3b8hyyr	2744	15	infantile	infantile	JJ
cord-006860-a3b8hyyr	2744	16	VK	VK	NNP
cord-006860-a3b8hyyr	2744	17	deficiency	deficiency	NN
cord-006860-a3b8hyyr	2744	18	was	be	VBD
cord-006860-a3b8hyyr	2744	19	1:4000	1:4000	CD
cord-006860-a3b8hyyr	2745	1	both	both	DT
cord-006860-a3b8hyyr	2745	2	idiopathic	idiopathic	JJ
cord-006860-a3b8hyyr	2745	3	and	and	CC
cord-006860-a3b8hyyr	2745	4	secondary	secondary	JJ
cord-006860-a3b8hyyr	2745	5	types	type	NNS
cord-006860-a3b8hyyr	2745	6	.	.	.
cord-006860-a3b8hyyr	2746	1	Since	since	IN
cord-006860-a3b8hyyr	2746	2	1981	1981	CD
cord-006860-a3b8hyyr	2746	3	,	,	,
cord-006860-a3b8hyyr	2746	4	4	4	CD
cord-006860-a3b8hyyr	2746	5	nationwide	nationwide	JJ
cord-006860-a3b8hyyr	2746	6	surveys	survey	NNS
cord-006860-a3b8hyyr	2746	7	have	have	VBP
cord-006860-a3b8hyyr	2746	8	been	be	VBN
cord-006860-a3b8hyyr	2746	9	conducted	conduct	VBN
cord-006860-a3b8hyyr	2746	10	.	.	.
cord-006860-a3b8hyyr	2747	1	The	the	DT
cord-006860-a3b8hyyr	2747	2	current	current	JJ
cord-006860-a3b8hyyr	2747	3	incidence	incidence	NN
cord-006860-a3b8hyyr	2747	4	rate	rate	NN
cord-006860-a3b8hyyr	2747	5	is	be	VBZ
cord-006860-a3b8hyyr	2747	6	now	now	RB
cord-006860-a3b8hyyr	2747	7	about	about	RB
cord-006860-a3b8hyyr	2747	8	one	one	CD
cord-006860-a3b8hyyr	2747	9	-	-	HYPH
cord-006860-a3b8hyyr	2747	10	tenth	tenth	NN
cord-006860-a3b8hyyr	2747	11	that	that	IN
cord-006860-a3b8hyyr	2747	12	in	in	IN
cord-006860-a3b8hyyr	2747	13	early	early	JJ
cord-006860-a3b8hyyr	2747	14	1980	1980	CD
cord-006860-a3b8hyyr	2747	15	.	.	.
cord-006860-a3b8hyyr	2748	1	However	however	RB
cord-006860-a3b8hyyr	2748	2	,	,	,
cord-006860-a3b8hyyr	2748	3	in	in	IN
cord-006860-a3b8hyyr	2748	4	a	a	DT
cord-006860-a3b8hyyr	2748	5	small	small	JJ
cord-006860-a3b8hyyr	2748	6	number	number	NN
cord-006860-a3b8hyyr	2748	7	of	of	IN
cord-006860-a3b8hyyr	2748	8	eases	ease	NNS
cord-006860-a3b8hyyr	2748	9	,	,	,
cord-006860-a3b8hyyr	2748	10	VK	VK	NNP
cord-006860-a3b8hyyr	2748	11	deficiency	deficiency	NN
cord-006860-a3b8hyyr	2748	12	oceured	oceure	VBD
cord-006860-a3b8hyyr	2748	13	despite	despite	IN
cord-006860-a3b8hyyr	2748	14	prophylactic	prophylactic	JJ
cord-006860-a3b8hyyr	2748	15	administration	administration	NN
cord-006860-a3b8hyyr	2748	16	during	during	IN
cord-006860-a3b8hyyr	2748	17	the	the	DT
cord-006860-a3b8hyyr	2748	18	neonatal	neonatal	JJ
cord-006860-a3b8hyyr	2748	19	period	period	NN
cord-006860-a3b8hyyr	2748	20	.	.	.
cord-006860-a3b8hyyr	2749	1	In	in	IN
cord-006860-a3b8hyyr	2749	2	order	order	NN
cord-006860-a3b8hyyr	2749	3	to	to	TO
cord-006860-a3b8hyyr	2749	4	clarify	clarify	VB
cord-006860-a3b8hyyr	2749	5	the	the	DT
cord-006860-a3b8hyyr	2749	6	absorption	absorption	NN
cord-006860-a3b8hyyr	2749	7	,	,	,
cord-006860-a3b8hyyr	2749	8	excretion	excretion	NN
cord-006860-a3b8hyyr	2749	9	and	and	CC
cord-006860-a3b8hyyr	2749	10	transplacental	transplacental	JJ
cord-006860-a3b8hyyr	2749	11	transport	transport	NN
cord-006860-a3b8hyyr	2749	12	of	of	IN
cord-006860-a3b8hyyr	2749	13	VK	VK	NNP
cord-006860-a3b8hyyr	2749	14	in	in	IN
cord-006860-a3b8hyyr	2749	15	the	the	DT
cord-006860-a3b8hyyr	2749	16	perinatal	perinatal	JJ
cord-006860-a3b8hyyr	2749	17	period	period	NN
cord-006860-a3b8hyyr	2749	18	,	,	,
cord-006860-a3b8hyyr	2749	19	following	follow	VBG
cord-006860-a3b8hyyr	2749	20	studies	study	NNS
cord-006860-a3b8hyyr	2749	21	were	be	VBD
cord-006860-a3b8hyyr	2749	22	carried	carry	VBN
cord-006860-a3b8hyyr	2749	23	out	out	RP
cord-006860-a3b8hyyr	2749	24	.	.	.
cord-006860-a3b8hyyr	2750	1	t)Hepaplastintest(Normotest	t)Hepaplastintest(Normotest	NNP
cord-006860-a3b8hyyr	2750	2	)	)	-RRB-
cord-006860-a3b8hyyr	2750	3	were	be	VBD
cord-006860-a3b8hyyr	2750	4	performed	perform	VBN
cord-006860-a3b8hyyr	2750	5	on	on	IN
cord-006860-a3b8hyyr	2750	6	65	65	CD
cord-006860-a3b8hyyr	2750	7	women	woman	NNS
cord-006860-a3b8hyyr	2750	8	in	in	IN
cord-006860-a3b8hyyr	2750	9	the	the	DT
cord-006860-a3b8hyyr	2750	10	last	last	JJ
cord-006860-a3b8hyyr	2750	11	stage	stage	NN
cord-006860-a3b8hyyr	2750	12	of	of	IN
cord-006860-a3b8hyyr	2750	13	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	2750	14	and	and	CC
cord-006860-a3b8hyyr	2750	15	each	each	DT
cord-006860-a3b8hyyr	2750	16	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2750	17	factor	factor	NN
cord-006860-a3b8hyyr	2750	18	was	be	VBD
cord-006860-a3b8hyyr	2750	19	estimated	estimate	VBN
cord-006860-a3b8hyyr	2750	20	as	as	RB
cord-006860-a3b8hyyr	2750	21	well	well	RB
cord-006860-a3b8hyyr	2750	22	.	.	.
cord-006860-a3b8hyyr	2751	1	2)Correlations	2)correlation	NNS
cord-006860-a3b8hyyr	2751	2	were	be	VBD
cord-006860-a3b8hyyr	2751	3	made	make	VBN
cord-006860-a3b8hyyr	2751	4	between	between	IN
cord-006860-a3b8hyyr	2751	5	mothers'and	mothers'and	NN
cord-006860-a3b8hyyr	2751	6	babies'Hepaplastin	babies'Hepaplastin	NNP
cord-006860-a3b8hyyr	2751	7	test	test	NN
cord-006860-a3b8hyyr	2751	8	values	value	NNS
cord-006860-a3b8hyyr	2751	9	.	.	.
cord-006860-a3b8hyyr	2752	1	3)Transplacental	3)transplacental	CD
cord-006860-a3b8hyyr	2752	2	transport	transport	NN
cord-006860-a3b8hyyr	2752	3	of	of	IN
cord-006860-a3b8hyyr	2752	4	VK	VK	NNP
cord-006860-a3b8hyyr	2752	5	2	2	CD
cord-006860-a3b8hyyr	2752	6	was	be	VBD
cord-006860-a3b8hyyr	2752	7	studied	study	VBN
cord-006860-a3b8hyyr	2752	8	.	.	.
cord-006860-a3b8hyyr	2753	1	The	the	DT
cord-006860-a3b8hyyr	2753	2	general	general	JJ
cord-006860-a3b8hyyr	2753	3	activity	activity	NN
cord-006860-a3b8hyyr	2753	4	of	of	IN
cord-006860-a3b8hyyr	2753	5	VK	VK	NNP
cord-006860-a3b8hyyr	2753	6	dependent	dependent	JJ
cord-006860-a3b8hyyr	2753	7	factors	factor	NNS
cord-006860-a3b8hyyr	2753	8	in	in	IN
cord-006860-a3b8hyyr	2753	9	pregnant	pregnant	JJ
cord-006860-a3b8hyyr	2753	10	women	woman	NNS
cord-006860-a3b8hyyr	2753	11	was	be	VBD
cord-006860-a3b8hyyr	2753	12	much	much	RB
cord-006860-a3b8hyyr	2753	13	higher	high	JJR
cord-006860-a3b8hyyr	2753	14	than	than	IN
cord-006860-a3b8hyyr	2753	15	in	in	IN
cord-006860-a3b8hyyr	2753	16	non	non	JJ
cord-006860-a3b8hyyr	2753	17	pregnant	pregnant	JJ
cord-006860-a3b8hyyr	2753	18	women	woman	NNS
cord-006860-a3b8hyyr	2753	19	.	.	.
cord-006860-a3b8hyyr	2754	1	As	as	RB
cord-006860-a3b8hyyr	2754	2	far	far	RB
cord-006860-a3b8hyyr	2754	3	as	as	IN
cord-006860-a3b8hyyr	2754	4	the	the	DT
cord-006860-a3b8hyyr	2754	5	correlation	correlation	NN
cord-006860-a3b8hyyr	2754	6	between	between	IN
cord-006860-a3b8hyyr	2754	7	mothers'venous	mothers'venous	JJ
cord-006860-a3b8hyyr	2754	8	blood	blood	NN
cord-006860-a3b8hyyr	2754	9	during	during	IN
cord-006860-a3b8hyyr	2754	10	delivery	delivery	NN
cord-006860-a3b8hyyr	2754	11	and	and	CC
cord-006860-a3b8hyyr	2754	12	cordvenous	cordvenous	JJ
cord-006860-a3b8hyyr	2754	13	blood	blood	NN
cord-006860-a3b8hyyr	2754	14	is	be	VBZ
cord-006860-a3b8hyyr	2754	15	concerned	concern	VBN
cord-006860-a3b8hyyr	2754	16	,	,	,
cord-006860-a3b8hyyr	2754	17	in	in	IN
cord-006860-a3b8hyyr	2754	18	the	the	DT
cord-006860-a3b8hyyr	2754	19	group	group	NN
cord-006860-a3b8hyyr	2754	20	of	of	IN
cord-006860-a3b8hyyr	2754	21	mothers	mother	NNS
cord-006860-a3b8hyyr	2754	22	with	with	IN
cord-006860-a3b8hyyr	2754	23	Hepaplastin	Hepaplastin	NNP
cord-006860-a3b8hyyr	2754	24	test	test	NN
cord-006860-a3b8hyyr	2754	25	value	value	NN
cord-006860-a3b8hyyr	2754	26	of	of	IN
cord-006860-a3b8hyyr	2754	27	less	less	JJR
cord-006860-a3b8hyyr	2754	28	than	than	IN
cord-006860-a3b8hyyr	2754	29	120	120	CD
cord-006860-a3b8hyyr	2754	30	%	%	NN
cord-006860-a3b8hyyr	2754	31	of	of	IN
cord-006860-a3b8hyyr	2754	32	the	the	DT
cord-006860-a3b8hyyr	2754	33	normal	normal	JJ
cord-006860-a3b8hyyr	2754	34	adult	adult	NN
cord-006860-a3b8hyyr	2754	35	value	value	NN
cord-006860-a3b8hyyr	2754	36	,	,	,
cord-006860-a3b8hyyr	2754	37	the	the	DT
cord-006860-a3b8hyyr	2754	38	value	value	NN
cord-006860-a3b8hyyr	2754	39	of	of	IN
cord-006860-a3b8hyyr	2754	40	the	the	DT
cord-006860-a3b8hyyr	2754	41	Hepaplastintest	Hepaplastintest	NNP
cord-006860-a3b8hyyr	2754	42	was	be	VBD
cord-006860-a3b8hyyr	2754	43	less	less	JJR
cord-006860-a3b8hyyr	2754	44	than	than	IN
cord-006860-a3b8hyyr	2754	45	30	30	CD
cord-006860-a3b8hyyr	2754	46	%	%	NN
cord-006860-a3b8hyyr	2754	47	of	of	IN
cord-006860-a3b8hyyr	2754	48	normal	normal	JJ
cord-006860-a3b8hyyr	2754	49	adult	adult	NN
cord-006860-a3b8hyyr	2754	50	value	value	NN
cord-006860-a3b8hyyr	2754	51	in	in	IN
cord-006860-a3b8hyyr	2754	52	the	the	DT
cord-006860-a3b8hyyr	2754	53	cord	cord	NN
cord-006860-a3b8hyyr	2754	54	venous	venous	JJ
cord-006860-a3b8hyyr	2754	55	blood	blood	NN
cord-006860-a3b8hyyr	2754	56	°	°	NN
cord-006860-a3b8hyyr	2755	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2755	2	also	also	RB
cord-006860-a3b8hyyr	2755	3	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	2755	4	that	that	IN
cord-006860-a3b8hyyr	2755	5	VK	VK	NNP
cord-006860-a3b8hyyr	2755	6	passed	pass	VBD
cord-006860-a3b8hyyr	2755	7	through	through	IN
cord-006860-a3b8hyyr	2755	8	the	the	DT
cord-006860-a3b8hyyr	2755	9	placenta	placenta	NN
cord-006860-a3b8hyyr	2755	10	but	but	CC
cord-006860-a3b8hyyr	2755	11	only	only	RB
cord-006860-a3b8hyyr	2755	12	in	in	IN
cord-006860-a3b8hyyr	2755	13	small	small	JJ
cord-006860-a3b8hyyr	2755	14	qualities	quality	NNS
cord-006860-a3b8hyyr	2755	15	.	.	.
cord-006860-a3b8hyyr	2756	1	61HIV	61hiv	JJ
cord-006860-a3b8hyyr	2756	2	-	-	JJ
cord-006860-a3b8hyyr	2756	3	negative	negative	JJ
cord-006860-a3b8hyyr	2756	4	patients	patient	NNS
cord-006860-a3b8hyyr	2756	5	(	(	-LRB-
cord-006860-a3b8hyyr	2756	6	median	median	JJ
cord-006860-a3b8hyyr	2756	7	age	age	NN
cord-006860-a3b8hyyr	2756	8	4]yrs	4]yrs	CD
cord-006860-a3b8hyyr	2756	9	,	,	,
cord-006860-a3b8hyyr	2756	10	13	13	CD
cord-006860-a3b8hyyr	2756	11	-	-	SYM
cord-006860-a3b8hyyr	2756	12	70	70	CD
cord-006860-a3b8hyyr	2756	13	}	}	-RRB-
cord-006860-a3b8hyyr	2756	14	,	,	,
cord-006860-a3b8hyyr	2756	15	formerly	formerly	RB
cord-006860-a3b8hyyr	2756	16	treated	treat	VBN
cord-006860-a3b8hyyr	2756	17	with	with	IN
cord-006860-a3b8hyyr	2756	18	non	non	JJ
cord-006860-a3b8hyyr	2756	19	-	-	JJ
cord-006860-a3b8hyyr	2756	20	virusinactivated	virusinactivated	JJ
cord-006860-a3b8hyyr	2756	21	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2756	22	products	product	NNS
cord-006860-a3b8hyyr	2756	23	,	,	,
cord-006860-a3b8hyyr	2756	24	underwent	undergo	VBD
cord-006860-a3b8hyyr	2756	25	hepatologic	hepatologic	NNP
cord-006860-a3b8hyyr	2756	26	examination	examination	NN
cord-006860-a3b8hyyr	2756	27	,	,	,
cord-006860-a3b8hyyr	2756	28	including	include	VBG
cord-006860-a3b8hyyr	2756	29	AFP	AFP	NNP
cord-006860-a3b8hyyr	2756	30	screening	screening	NN
cord-006860-a3b8hyyr	2756	31	and	and	CC
cord-006860-a3b8hyyr	2756	32	sonography	sonography	NN
cord-006860-a3b8hyyr	2756	33	.	.	.
cord-006860-a3b8hyyr	2757	1	31.suffer	31.suffer	NNS
cord-006860-a3b8hyyr	2757	2	from	from	IN
cord-006860-a3b8hyyr	2757	3	severe	severe	JJ
cord-006860-a3b8hyyr	2757	4	,	,	,
cord-006860-a3b8hyyr	2757	5	20	20	CD
cord-006860-a3b8hyyr	2757	6	from	from	IN
cord-006860-a3b8hyyr	2757	7	moderate	moderate	JJ
cord-006860-a3b8hyyr	2757	8	or	or	CC
cord-006860-a3b8hyyr	2757	9	mild	mild	JJ
cord-006860-a3b8hyyr	2757	10	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	2757	11	A	a	NN
cord-006860-a3b8hyyr	2757	12	or	or	CC
cord-006860-a3b8hyyr	2757	13	B	b	NN
cord-006860-a3b8hyyr	2757	14	,	,	,
cord-006860-a3b8hyyr	2757	15	10	10	CD
cord-006860-a3b8hyyr	2757	16	from	from	IN
cord-006860-a3b8hyyr	2757	17	other	other	JJ
cord-006860-a3b8hyyr	2757	18	severe	severe	JJ
cord-006860-a3b8hyyr	2757	19	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2757	20	factor	factor	NN
cord-006860-a3b8hyyr	2757	21	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	2757	22	.	.	.
cord-006860-a3b8hyyr	2758	1	52	52	CD
cord-006860-a3b8hyyr	2758	2	had	have	VBD
cord-006860-a3b8hyyr	2758	3	been	be	VBN
cord-006860-a3b8hyyr	2758	4	treated	treat	VBN
cord-006860-a3b8hyyr	2758	5	with	with	IN
cord-006860-a3b8hyyr	2758	6	products	product	NNS
cord-006860-a3b8hyyr	2758	7	of	of	IN
cord-006860-a3b8hyyr	2758	8	the	the	DT
cord-006860-a3b8hyyr	2758	9	Swiss	Swiss	NNP
cord-006860-a3b8hyyr	2758	10	Red	Red	NNP
cord-006860-a3b8hyyr	2758	11	Cross	Cross	NNP
cord-006860-a3b8hyyr	2758	12	(	(	-LRB-
cord-006860-a3b8hyyr	2758	13	SRC	SRC	NNP
cord-006860-a3b8hyyr	2758	14	)	)	-RRB-
cord-006860-a3b8hyyr	2758	15	only	only	RB
cord-006860-a3b8hyyr	2758	16	(	(	-LRB-
cord-006860-a3b8hyyr	2758	17	28	28	CD
cord-006860-a3b8hyyr	2758	18	with	with	IN
cord-006860-a3b8hyyr	2758	19	small	small	JJ
cord-006860-a3b8hyyr	2758	20	pool	pool	NN
cord-006860-a3b8hyyr	2758	21	cryoprecipitate	cryoprecipitate	NNP
cord-006860-a3b8hyyr	2758	22	}	}	-RRB-
cord-006860-a3b8hyyr	2758	23	,	,	,
cord-006860-a3b8hyyr	2758	24	4	4	CD
cord-006860-a3b8hyyr	2758	25	with	with	IN
cord-006860-a3b8hyyr	2758	26	foreign	foreign	JJ
cord-006860-a3b8hyyr	2758	27	products	product	NNS
cord-006860-a3b8hyyr	2758	28	only	only	RB
cord-006860-a3b8hyyr	2758	29	,	,	,
cord-006860-a3b8hyyr	2758	30	5	5	CD
cord-006860-a3b8hyyr	2758	31	with	with	IN
cord-006860-a3b8hyyr	2758	32	both	both	CC
cord-006860-a3b8hyyr	2758	33	SRC	SRC	NNP
cord-006860-a3b8hyyr	2758	34	and	and	CC
cord-006860-a3b8hyyr	2758	35	foreign	foreign	JJ
cord-006860-a3b8hyyr	2758	36	products	product	NNS
cord-006860-a3b8hyyr	2758	37	.	.	.
cord-006860-a3b8hyyr	2759	1	Treatment	treatment	NN
cord-006860-a3b8hyyr	2759	2	intensity	intensity	NN
cord-006860-a3b8hyyr	2759	3	was	be	VBD
cord-006860-a3b8hyyr	2759	4	variable	variable	JJ
cord-006860-a3b8hyyr	2759	5	with>20'000	with>20'000	:
cord-006860-a3b8hyyr	2759	6	IU	IU	NNP
cord-006860-a3b8hyyr	2759	7	/	/	SYM
cord-006860-a3b8hyyr	2759	8	yr	yr	NN
cord-006860-a3b8hyyr	2759	9	in	in	IN
cord-006860-a3b8hyyr	2759	10	26	26	CD
cord-006860-a3b8hyyr	2759	11	,	,	,
cord-006860-a3b8hyyr	2759	12	<	<	XX
cord-006860-a3b8hyyr	2759	13	20'000	20'000	CD
cord-006860-a3b8hyyr	2759	14	in	in	IN
cord-006860-a3b8hyyr	2759	15	]	]	-RRB-
cord-006860-a3b8hyyr	2759	16	6	6	CD
cord-006860-a3b8hyyr	2759	17	,	,	,
cord-006860-a3b8hyyr	2759	18	<	<	XX
cord-006860-a3b8hyyr	2759	19	1	1	CD
cord-006860-a3b8hyyr	2759	20	treatment	treatment	NN
cord-006860-a3b8hyyr	2759	21	episode	episode	NN
cord-006860-a3b8hyyr	2759	22	/	/	SYM
cord-006860-a3b8hyyr	2759	23	yr	yr	NN
cord-006860-a3b8hyyr	2759	24	in	in	IN
cord-006860-a3b8hyyr	2759	25	]	]	-RRB-
cord-006860-a3b8hyyr	2759	26	0	0	CD
cord-006860-a3b8hyyr	2759	27	,	,	,
cord-006860-a3b8hyyr	2759	28	a	a	DT
cord-006860-a3b8hyyr	2759	29	total	total	NN
cord-006860-a3b8hyyr	2759	30	of	of	IN
cord-006860-a3b8hyyr	2759	31	only	only	RB
cord-006860-a3b8hyyr	2759	32	1	1	CD
cord-006860-a3b8hyyr	2759	33	-	-	SYM
cord-006860-a3b8hyyr	2759	34	3	3	CD
cord-006860-a3b8hyyr	2759	35	treatment	treatment	NN
cord-006860-a3b8hyyr	2759	36	courses	course	NNS
cord-006860-a3b8hyyr	2759	37	in	in	IN
cord-006860-a3b8hyyr	2759	38	6	6	CD
cord-006860-a3b8hyyr	2759	39	patients	patient	NNS
cord-006860-a3b8hyyr	2759	40	.	.	.
cord-006860-a3b8hyyr	2760	1	3	3	CD
cord-006860-a3b8hyyr	2760	2	afibrinogenemic	afibrinogenemic	NNP
cord-006860-a3b8hyyr	2760	3	patients	patient	NNS
cord-006860-a3b8hyyr	2760	4	had	have	VBD
cord-006860-a3b8hyyr	2760	5	prophylactic	prophylactic	JJ
cord-006860-a3b8hyyr	2760	6	replacement	replacement	NN
cord-006860-a3b8hyyr	2760	7	therapy	therapy	NN
cord-006860-a3b8hyyr	2760	8	.	.	.
cord-006860-a3b8hyyr	2761	1	HCV	HCV	NNP
cord-006860-a3b8hyyr	2761	2	serology	serology	NN
cord-006860-a3b8hyyr	2761	3	was	be	VBD
cord-006860-a3b8hyyr	2761	4	positive	positive	JJ
cord-006860-a3b8hyyr	2761	5	in	in	IN
cord-006860-a3b8hyyr	2761	6	56/6	56/6	CD
cord-006860-a3b8hyyr	2761	7	]	]	-RRB-
cord-006860-a3b8hyyr	2761	8	patients	patient	NNS
cord-006860-a3b8hyyr	2761	9	(	(	-LRB-
cord-006860-a3b8hyyr	2761	10	92	92	CD
cord-006860-a3b8hyyr	2761	11	%	%	NN
cord-006860-a3b8hyyr	2761	12	)	)	-RRB-
cord-006860-a3b8hyyr	2761	13	,	,	,
cord-006860-a3b8hyyr	2761	14	in	in	IN
cord-006860-a3b8hyyr	2761	15	47	47	CD
cord-006860-a3b8hyyr	2761	16	with	with	IN
cord-006860-a3b8hyyr	2761	17	detectable	detectable	JJ
cord-006860-a3b8hyyr	2761	18	HCV	HCV	NNP
cord-006860-a3b8hyyr	2761	19	RNA	RNA	NNP
cord-006860-a3b8hyyr	2761	20	(	(	-LRB-
cord-006860-a3b8hyyr	2761	21	77	77	CD
cord-006860-a3b8hyyr	2761	22	%	%	NN
cord-006860-a3b8hyyr	2761	23	)	)	-RRB-
cord-006860-a3b8hyyr	2761	24	.	.	.
cord-006860-a3b8hyyr	2762	1	The	the	DT
cord-006860-a3b8hyyr	2762	2	5	5	CD
cord-006860-a3b8hyyr	2762	3	persons	person	NNS
cord-006860-a3b8hyyr	2762	4	who	who	WP
cord-006860-a3b8hyyr	2762	5	escaped	escape	VBD
cord-006860-a3b8hyyr	2762	6	HCV	HCV	NNP
cord-006860-a3b8hyyr	2762	7	infection	infection	NN
cord-006860-a3b8hyyr	2762	8	,	,	,
cord-006860-a3b8hyyr	2762	9	with	with	IN
cord-006860-a3b8hyyr	2762	10	normal	normal	JJ
cord-006860-a3b8hyyr	2762	11	ALT	alt	NN
cord-006860-a3b8hyyr	2762	12	-	-	HYPH
cord-006860-a3b8hyyr	2762	13	levels	level	NNS
cord-006860-a3b8hyyr	2762	14	and	and	CC
cord-006860-a3b8hyyr	2762	15	without	without	IN
cord-006860-a3b8hyyr	2762	16	sonographic	sonographic	JJ
cord-006860-a3b8hyyr	2762	17	alterations	alteration	NNS
cord-006860-a3b8hyyr	2762	18	,	,	,
cord-006860-a3b8hyyr	2762	19	had	have	VBD
cord-006860-a3b8hyyr	2762	20	low	low	JJ
cord-006860-a3b8hyyr	2762	21	intensity	intensity	NN
cord-006860-a3b8hyyr	2762	22	treatment	treatment	NN
cord-006860-a3b8hyyr	2762	23	with	with	IN
cord-006860-a3b8hyyr	2762	24	small	small	JJ
cord-006860-a3b8hyyr	2762	25	pool	pool	NN
cord-006860-a3b8hyyr	2762	26	SRC	SRC	NNP
cord-006860-a3b8hyyr	2762	27	preparations	preparation	NNS
cord-006860-a3b8hyyr	2763	1	Only	only	RB
cord-006860-a3b8hyyr	2763	2	.	.	.
cord-006860-a3b8hyyr	2764	1	ALT	alt	NN
cord-006860-a3b8hyyr	2764	2	-	-	HYPH
cord-006860-a3b8hyyr	2764	3	levels	level	NNS
cord-006860-a3b8hyyr	2764	4	were	be	VBD
cord-006860-a3b8hyyr	2764	5	elevated	elevate	VBN
cord-006860-a3b8hyyr	2764	6	in	in	IN
cord-006860-a3b8hyyr	2764	7	33/56	33/56	CD
cord-006860-a3b8hyyr	2764	8	Anti	Anti	NNP
cord-006860-a3b8hyyr	2764	9	-	-	JJ
cord-006860-a3b8hyyr	2764	10	HCV	HCV	NNP
cord-006860-a3b8hyyr	2764	11	positive	positive	JJ
cord-006860-a3b8hyyr	2764	12	patients	patient	NNS
cord-006860-a3b8hyyr	2764	13	(	(	-LRB-
cord-006860-a3b8hyyr	2764	14	59	59	CD
cord-006860-a3b8hyyr	2764	15	%	%	NN
cord-006860-a3b8hyyr	2764	16	)	)	-RRB-
cord-006860-a3b8hyyr	2764	17	.	.	.
cord-006860-a3b8hyyr	2765	1	26/56	26/56	CD
cord-006860-a3b8hyyr	2765	2	had	have	VBD
cord-006860-a3b8hyyr	2765	3	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	2765	4	sonographic	sonographic	JJ
cord-006860-a3b8hyyr	2765	5	findings	finding	NNS
cord-006860-a3b8hyyr	2765	6	(	(	-LRB-
cord-006860-a3b8hyyr	2765	7	46	46	CD
cord-006860-a3b8hyyr	2765	8	%	%	NN
cord-006860-a3b8hyyr	2765	9	)	)	-RRB-
cord-006860-a3b8hyyr	2765	10	.	.	.
cord-006860-a3b8hyyr	2766	1	There	there	EX
cord-006860-a3b8hyyr	2766	2	was	be	VBD
cord-006860-a3b8hyyr	2766	3	a	a	DT
cord-006860-a3b8hyyr	2766	4	clear	clear	JJ
cord-006860-a3b8hyyr	2766	5	correlation	correlation	NN
cord-006860-a3b8hyyr	2766	6	between	between	IN
cord-006860-a3b8hyyr	2766	7	elevated	elevated	JJ
cord-006860-a3b8hyyr	2766	8	ALT	alt	NN
cord-006860-a3b8hyyr	2766	9	-	-	HYPH
cord-006860-a3b8hyyr	2766	10	levels	level	NNS
cord-006860-a3b8hyyr	2766	11	and	and	CC
cord-006860-a3b8hyyr	2766	12	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	2766	13	sonographies	sonography	NNS
cord-006860-a3b8hyyr	2766	14	:	:	:
cord-006860-a3b8hyyr	2766	15	Of	of	IN
cord-006860-a3b8hyyr	2766	16	33	33	CD
cord-006860-a3b8hyyr	2766	17	patients	patient	NNS
cord-006860-a3b8hyyr	2766	18	with	with	IN
cord-006860-a3b8hyyr	2766	19	elevated	elevated	JJ
cord-006860-a3b8hyyr	2766	20	ALT	alt	NN
cord-006860-a3b8hyyr	2766	21	23	23	CD
cord-006860-a3b8hyyr	2766	22	had	have	VBD
cord-006860-a3b8hyyr	2766	23	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	2766	24	sonography	sonography	NN
cord-006860-a3b8hyyr	2766	25	,	,	,
cord-006860-a3b8hyyr	2766	26	of	of	IN
cord-006860-a3b8hyyr	2766	27	23	23	CD
cord-006860-a3b8hyyr	2766	28	with	with	IN
cord-006860-a3b8hyyr	2766	29	normal	normal	JJ
cord-006860-a3b8hyyr	2766	30	ALT	alt	NN
cord-006860-a3b8hyyr	2766	31	3	3	CD
cord-006860-a3b8hyyr	2766	32	had	have	VBD
cord-006860-a3b8hyyr	2766	33	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	2766	34	sonography	sonography	NN
cord-006860-a3b8hyyr	2766	35	.	.	.
cord-006860-a3b8hyyr	2767	1	8	8	CD
cord-006860-a3b8hyyr	2767	2	patients	patient	NNS
cord-006860-a3b8hyyr	2767	3	had	have	VBD
cord-006860-a3b8hyyr	2767	4	liver	liver	NN
cord-006860-a3b8hyyr	2767	5	cirrhosis	cirrhosis	NN
cord-006860-a3b8hyyr	2767	6	(	(	-LRB-
cord-006860-a3b8hyyr	2767	7	6	6	CD
cord-006860-a3b8hyyr	2767	8	with	with	IN
cord-006860-a3b8hyyr	2767	9	clinically	clinically	RB
cord-006860-a3b8hyyr	2767	10	overt	overt	JJ
cord-006860-a3b8hyyr	2767	11	hepatopathy	hepatopathy	NN
cord-006860-a3b8hyyr	2767	12	)	)	-RRB-
cord-006860-a3b8hyyr	2767	13	,	,	,
cord-006860-a3b8hyyr	2767	14	4	4	CD
cord-006860-a3b8hyyr	2767	15	(	(	-LRB-
cord-006860-a3b8hyyr	2767	16	4/56	4/56	CD
cord-006860-a3b8hyyr	2767	17	=	=	SYM
cord-006860-a3b8hyyr	2767	18	1	1	CD
cord-006860-a3b8hyyr	2767	19	%	%	NN
cord-006860-a3b8hyyr	2767	20	!	!	.
cord-006860-a3b8hyyr	2767	21	)	)	-RRB-
cord-006860-a3b8hyyr	2768	1	with	with	IN
cord-006860-a3b8hyyr	2768	2	hepatocellu]ar	hepatocellu]ar	ADD
cord-006860-a3b8hyyr	2768	3	carcinoma	carcinoma	NNP
cord-006860-a3b8hyyr	2768	4	(	(	-LRB-
cord-006860-a3b8hyyr	2768	5	HCC	HCC	NNP
cord-006860-a3b8hyyr	2768	6	)	)	-RRB-
cord-006860-a3b8hyyr	2768	7	with	with	IN
cord-006860-a3b8hyyr	2768	8	elevated	elevated	JJ
cord-006860-a3b8hyyr	2768	9	AFP	AFP	NNP
cord-006860-a3b8hyyr	2768	10	-	-	HYPH
cord-006860-a3b8hyyr	2768	11	leveIs	leveIs	NNP
cord-006860-a3b8hyyr	2768	12	.	.	.
cord-006860-a3b8hyyr	2769	1	Of	of	IN
cord-006860-a3b8hyyr	2769	2	these	these	DT
cord-006860-a3b8hyyr	2769	3	4	4	CD
cord-006860-a3b8hyyr	2769	4	patients	patient	NNS
cord-006860-a3b8hyyr	2769	5	2	2	CD
cord-006860-a3b8hyyr	2769	6	had	have	VBD
cord-006860-a3b8hyyr	2769	7	intraarterial	intraarterial	JJ
cord-006860-a3b8hyyr	2769	8	embolization	embolization	NN
cord-006860-a3b8hyyr	2769	9	with	with	IN
cord-006860-a3b8hyyr	2769	10	]	]	-RRB-
cord-006860-a3b8hyyr	2769	11	ipiodol	ipiodol	JJ
cord-006860-a3b8hyyr	2769	12	-	-	HYPH
cord-006860-a3b8hyyr	2769	13	epirubicin	epirubicin	NNP
cord-006860-a3b8hyyr	2769	14	;	;	:
cord-006860-a3b8hyyr	2769	15	in	in	IN
cord-006860-a3b8hyyr	2769	16	2	2	CD
cord-006860-a3b8hyyr	2769	17	patients	patient	NNS
cord-006860-a3b8hyyr	2769	18	HCC	HCC	NNP
cord-006860-a3b8hyyr	2769	19	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	2769	20	was	be	VBD
cord-006860-a3b8hyyr	2769	21	made	make	VBN
cord-006860-a3b8hyyr	2769	22	in	in	IN
cord-006860-a3b8hyyr	2769	23	a	a	DT
cord-006860-a3b8hyyr	2769	24	late	late	JJ
cord-006860-a3b8hyyr	2769	25	stage	stage	NN
cord-006860-a3b8hyyr	2769	26	.	.	.
cord-006860-a3b8hyyr	2770	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	2770	2	patient	patient	VBP
cord-006860-a3b8hyyr	2770	3	with	with	IN
cord-006860-a3b8hyyr	2770	4	advanced	advanced	JJ
cord-006860-a3b8hyyr	2770	5	liver	liver	NN
cord-006860-a3b8hyyr	2770	6	cirrhosis	cirrhosis	NN
cord-006860-a3b8hyyr	2770	7	underwent	undergo	VBD
cord-006860-a3b8hyyr	2770	8	successful	successful	JJ
cord-006860-a3b8hyyr	2770	9	liver	liver	NN
cord-006860-a3b8hyyr	2770	10	transplantation	transplantation	NN
cord-006860-a3b8hyyr	2770	11	.	.	.
cord-006860-a3b8hyyr	2771	1	2	2	CD
cord-006860-a3b8hyyr	2771	2	of	of	IN
cord-006860-a3b8hyyr	2771	3	the	the	DT
cord-006860-a3b8hyyr	2771	4	6	6	CD
cord-006860-a3b8hyyr	2771	5	patients	patient	NNS
cord-006860-a3b8hyyr	2771	6	with	with	IN
cord-006860-a3b8hyyr	2771	7	hepatopathy	hepatopathy	NNP
cord-006860-a3b8hyyr	2771	8	had	have	VBD
cord-006860-a3b8hyyr	2771	9	severe	severe	JJ
cord-006860-a3b8hyyr	2771	10	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	2771	11	with	with	IN
cord-006860-a3b8hyyr	2771	12	temporary	temporary	JJ
cord-006860-a3b8hyyr	2771	13	high	high	JJ
cord-006860-a3b8hyyr	2771	14	alcohol	alcohol	NN
cord-006860-a3b8hyyr	2771	15	intake	intake	NN
cord-006860-a3b8hyyr	2771	16	,	,	,
cord-006860-a3b8hyyr	2771	17	4	4	CD
cord-006860-a3b8hyyr	2771	18	had	have	VBD
cord-006860-a3b8hyyr	2771	19	mild	mild	JJ
cord-006860-a3b8hyyr	2771	20	coagulatlon	coagulatlon	NN
cord-006860-a3b8hyyr	2771	21	disorder	disorder	NN
cord-006860-a3b8hyyr	2771	22	with	with	IN
cord-006860-a3b8hyyr	2771	23	few	few	JJ
cord-006860-a3b8hyyr	2771	24	treatment	treatment	NN
cord-006860-a3b8hyyr	2771	25	episodes	episode	NNS
cord-006860-a3b8hyyr	2771	26	.	.	.
cord-006860-a3b8hyyr	2772	1	Possible	possible	JJ
cord-006860-a3b8hyyr	2772	2	precipitating	precipitate	VBG
cord-006860-a3b8hyyr	2772	3	factors	factor	NNS
cord-006860-a3b8hyyr	2772	4	were	be	VBD
cord-006860-a3b8hyyr	2772	5	coinfection	coinfection	NN
cord-006860-a3b8hyyr	2772	6	with	with	IN
cord-006860-a3b8hyyr	2772	7	HBV	HBV	NNP
cord-006860-a3b8hyyr	2772	8	,	,	,
cord-006860-a3b8hyyr	2772	9	high	high	JJ
cord-006860-a3b8hyyr	2772	10	alcohol	alcohol	NN
cord-006860-a3b8hyyr	2772	11	consumation	consumation	NN
cord-006860-a3b8hyyr	2772	12	and	and	CC
cord-006860-a3b8hyyr	2772	13	first	first	JJ
cord-006860-a3b8hyyr	2772	14	exposure	exposure	NN
cord-006860-a3b8hyyr	2772	15	to	to	IN
cord-006860-a3b8hyyr	2772	16	HCV	HCV	NNP
cord-006860-a3b8hyyr	2772	17	contaminated	contaminate	VBD
cord-006860-a3b8hyyr	2772	18	blood	blood	NN
cord-006860-a3b8hyyr	2772	19	products	product	NNS
cord-006860-a3b8hyyr	2772	20	in	in	IN
cord-006860-a3b8hyyr	2772	21	an	an	DT
cord-006860-a3b8hyyr	2772	22	advanced	advanced	JJ
cord-006860-a3b8hyyr	2772	23	age	age	NN
cord-006860-a3b8hyyr	2772	24	,	,	,
cord-006860-a3b8hyyr	2772	25	but	but	CC
cord-006860-a3b8hyyr	2772	26	not	not	RB
cord-006860-a3b8hyyr	2772	27	intensive	intensive	JJ
cord-006860-a3b8hyyr	2772	28	replacement	replacement	NN
cord-006860-a3b8hyyr	2772	29	therapy	therapy	NN
cord-006860-a3b8hyyr	2772	30	.	.	.
cord-006860-a3b8hyyr	2773	1	very	very	RB
cord-006860-a3b8hyyr	2773	2	similar	similar	JJ
cord-006860-a3b8hyyr	2773	3	results	result	NNS
cord-006860-a3b8hyyr	2773	4	for	for	IN
cord-006860-a3b8hyyr	2773	5	F	F	NNP
cord-006860-a3b8hyyr	2773	6	Vlll	Vlll	NNP
cord-006860-a3b8hyyr	2773	7	and	and	CC
cord-006860-a3b8hyyr	2773	8	vWF	vwf	NN
cord-006860-a3b8hyyr	2773	9	.	.	.
cord-006860-a3b8hyyr	2774	1	Since	since	IN
cord-006860-a3b8hyyr	2774	2	the	the	DT
cord-006860-a3b8hyyr	2774	3	factor	factor	NN
cord-006860-a3b8hyyr	2774	4	VIII	VIII	NNP
cord-006860-a3b8hyyr	2774	5	level	level	NN
cord-006860-a3b8hyyr	2774	6	is	be	VBZ
cord-006860-a3b8hyyr	2774	7	kept	keep	VBN
cord-006860-a3b8hyyr	2774	8	steady	steady	JJ
cord-006860-a3b8hyyr	2774	9	above	above	IN
cord-006860-a3b8hyyr	2774	10	the	the	DT
cord-006860-a3b8hyyr	2774	11	level	level	NN
cord-006860-a3b8hyyr	2774	12	where	where	WRB
cord-006860-a3b8hyyr	2774	13	there	there	EX
cord-006860-a3b8hyyr	2774	14	is	be	VBZ
cord-006860-a3b8hyyr	2774	15	an	an	DT
cord-006860-a3b8hyyr	2774	16	increased	increased	JJ
cord-006860-a3b8hyyr	2774	17	risk	risk	NN
cord-006860-a3b8hyyr	2774	18	of	of	IN
cord-006860-a3b8hyyr	2774	19	haemorrhage	haemorrhage	NN
cord-006860-a3b8hyyr	2774	20	,	,	,
cord-006860-a3b8hyyr	2774	21	continuous	continuous	JJ
cord-006860-a3b8hyyr	2774	22	infusion	infusion	NN
cord-006860-a3b8hyyr	2774	23	is	be	VBZ
cord-006860-a3b8hyyr	2774	24	haemostatically	haemostatically	RB
cord-006860-a3b8hyyr	2774	25	safer	safe	JJR
cord-006860-a3b8hyyr	2774	26	and	and	CC
cord-006860-a3b8hyyr	2774	27	more	more	RBR
cord-006860-a3b8hyyr	2774	28	efficacious	efficacious	JJ
cord-006860-a3b8hyyr	2774	29	than	than	IN
cord-006860-a3b8hyyr	2774	30	bolus	bolus	NN
cord-006860-a3b8hyyr	2774	31	injections	injection	NNS
cord-006860-a3b8hyyr	2774	32	,	,	,
cord-006860-a3b8hyyr	2774	33	Another	another	DT
cord-006860-a3b8hyyr	2774	34	advantage	advantage	NN
cord-006860-a3b8hyyr	2774	35	is	be	VBZ
cord-006860-a3b8hyyr	2774	36	a	a	DT
cord-006860-a3b8hyyr	2774	37	progressive	progressive	JJ
cord-006860-a3b8hyyr	2774	38	decrease	decrease	NN
cord-006860-a3b8hyyr	2774	39	of	of	IN
cord-006860-a3b8hyyr	2774	40	clearence	clearence	NN
cord-006860-a3b8hyyr	2774	41	during	during	IN
cord-006860-a3b8hyyr	2774	42	the	the	DT
cord-006860-a3b8hyyr	2774	43	first	first	JJ
cord-006860-a3b8hyyr	2774	44	days	day	NNS
cord-006860-a3b8hyyr	2774	45	after	after	IN
cord-006860-a3b8hyyr	2774	46	surgery	surgery	NN
cord-006860-a3b8hyyr	2774	47	which	which	WDT
cord-006860-a3b8hyyr	2774	48	leads	lead	VBZ
cord-006860-a3b8hyyr	2774	49	to	to	IN
cord-006860-a3b8hyyr	2774	50	a	a	DT
cord-006860-a3b8hyyr	2774	51	substantial	substantial	JJ
cord-006860-a3b8hyyr	2774	52	reduction	reduction	NN
cord-006860-a3b8hyyr	2774	53	of	of	IN
cord-006860-a3b8hyyr	2774	54	factor	factor	NN
cord-006860-a3b8hyyr	2774	55	concentrate	concentrate	VBP
cord-006860-a3b8hyyr	2774	56	consumption	consumption	NN
cord-006860-a3b8hyyr	2774	57	by	by	IN
cord-006860-a3b8hyyr	2774	58	avoiding	avoid	VBG
cord-006860-a3b8hyyr	2774	59	the	the	DT
cord-006860-a3b8hyyr	2774	60	innecessary	innecessary	JJ
cord-006860-a3b8hyyr	2774	61	peaks	peak	NNS
cord-006860-a3b8hyyr	2774	62	of	of	IN
cord-006860-a3b8hyyr	2774	63	bolus	bolus	NN
cord-006860-a3b8hyyr	2774	64	injections	injection	NNS
cord-006860-a3b8hyyr	2774	65	.	.	.
cord-006860-a3b8hyyr	2775	1	22	22	CD
cord-006860-a3b8hyyr	2775	2	children	child	NNS
cord-006860-a3b8hyyr	2775	3	with	with	IN
cord-006860-a3b8hyyr	2775	4	severe	severe	JJ
cord-006860-a3b8hyyr	2775	5	form	form	NN
cord-006860-a3b8hyyr	2775	6	of	of	IN
cord-006860-a3b8hyyr	2775	7	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	2775	8	A	a	DT
cord-006860-a3b8hyyr	2775	9	undergoing	undergo	VBG
cord-006860-a3b8hyyr	2775	10	elective	elective	JJ
cord-006860-a3b8hyyr	2775	11	surgery	surgery	NN
cord-006860-a3b8hyyr	2775	12	received	receive	VBD
cord-006860-a3b8hyyr	2775	13	continuous	continuous	JJ
cord-006860-a3b8hyyr	2775	14	infusions	infusion	NNS
cord-006860-a3b8hyyr	2775	15	with	with	IN
cord-006860-a3b8hyyr	2775	16	different	different	JJ
cord-006860-a3b8hyyr	2775	17	plasma	plasma	NN
cord-006860-a3b8hyyr	2775	18	-	-	HYPH
cord-006860-a3b8hyyr	2775	19	derlved	derlved	JJ
cord-006860-a3b8hyyr	2775	20	and	and	CC
cord-006860-a3b8hyyr	2775	21	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	2775	22	F	F	NNP
cord-006860-a3b8hyyr	2775	23	VIII	VIII	NNP
cord-006860-a3b8hyyr	2775	24	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	2775	25	.	.	.
cord-006860-a3b8hyyr	2776	1	Before	before	IN
cord-006860-a3b8hyyr	2776	2	surgery	surgery	NN
cord-006860-a3b8hyyr	2776	3	,	,	,
cord-006860-a3b8hyyr	2776	4	patients	patient	NNS
cord-006860-a3b8hyyr	2776	5	got	get	VBD
cord-006860-a3b8hyyr	2776	6	bolus	bolus	NN
cord-006860-a3b8hyyr	2776	7	injections	injection	NNS
cord-006860-a3b8hyyr	2776	8	to	to	TO
cord-006860-a3b8hyyr	2776	9	raise	raise	VB
cord-006860-a3b8hyyr	2776	10	the	the	DT
cord-006860-a3b8hyyr	2776	11	factor	factor	NN
cord-006860-a3b8hyyr	2776	12	VIII	VIII	NNP
cord-006860-a3b8hyyr	2776	13	levels	level	NNS
cord-006860-a3b8hyyr	2776	14	to	to	IN
cord-006860-a3b8hyyr	2776	15	more	more	JJR
cord-006860-a3b8hyyr	2776	16	than	than	IN
cord-006860-a3b8hyyr	2776	17	80	80	CD
cord-006860-a3b8hyyr	2776	18	%	%	NN
cord-006860-a3b8hyyr	2776	19	.	.	.
cord-006860-a3b8hyyr	2777	1	During	during	IN
cord-006860-a3b8hyyr	2777	2	continuous	continuous	JJ
cord-006860-a3b8hyyr	2777	3	infusion	infusion	NN
cord-006860-a3b8hyyr	2777	4	factor	factor	NN
cord-006860-a3b8hyyr	2777	5	VIII	VIII	NNP
cord-006860-a3b8hyyr	2777	6	levels	level	NNS
cord-006860-a3b8hyyr	2777	7	were	be	VBD
cord-006860-a3b8hyyr	2777	8	measured	measure	VBN
cord-006860-a3b8hyyr	2777	9	two	two	CD
cord-006860-a3b8hyyr	2777	10	to	to	IN
cord-006860-a3b8hyyr	2777	11	three	three	CD
cord-006860-a3b8hyyr	2777	12	times	time	NNS
cord-006860-a3b8hyyr	2777	13	a	a	DT
cord-006860-a3b8hyyr	2777	14	day	day	NN
cord-006860-a3b8hyyr	2777	15	and	and	CC
cord-006860-a3b8hyyr	2777	16	the	the	DT
cord-006860-a3b8hyyr	2777	17	infusion	infusion	NN
cord-006860-a3b8hyyr	2777	18	rate	rate	NN
cord-006860-a3b8hyyr	2777	19	of	of	IN
cord-006860-a3b8hyyr	2777	20	4	4	CD
cord-006860-a3b8hyyr	2777	21	to	to	TO
cord-006860-a3b8hyyr	2777	22	5	5	CD
cord-006860-a3b8hyyr	2777	23	IU	IU	NNP
cord-006860-a3b8hyyr	2777	24	/	/	SYM
cord-006860-a3b8hyyr	2777	25	kg	kg	NNP
cord-006860-a3b8hyyr	2777	26	/	/	SYM
cord-006860-a3b8hyyr	2777	27	h	h	NN
cord-006860-a3b8hyyr	2777	28	could	could	MD
cord-006860-a3b8hyyr	2777	29	be	be	VB
cord-006860-a3b8hyyr	2777	30	reduced	reduce	VBN
cord-006860-a3b8hyyr	2777	31	on	on	IN
cord-006860-a3b8hyyr	2777	32	the	the	DT
cord-006860-a3b8hyyr	2777	33	second	second	JJ
cord-006860-a3b8hyyr	2777	34	or	or	CC
cord-006860-a3b8hyyr	2777	35	third	third	JJ
cord-006860-a3b8hyyr	2777	36	day	day	NN
cord-006860-a3b8hyyr	2777	37	to	to	IN
cord-006860-a3b8hyyr	2777	38	2	2	CD
cord-006860-a3b8hyyr	2777	39	-	-	SYM
cord-006860-a3b8hyyr	2777	40	3	3	CD
cord-006860-a3b8hyyr	2777	41	IU	IU	NNP
cord-006860-a3b8hyyr	2777	42	/	/	SYM
cord-006860-a3b8hyyr	2777	43	kg	kg	NNP
cord-006860-a3b8hyyr	2777	44	/	/	SYM
cord-006860-a3b8hyyr	2777	45	h	h	NN
cord-006860-a3b8hyyr	2777	46	.	.	.
cord-006860-a3b8hyyr	2778	1	The	the	DT
cord-006860-a3b8hyyr	2778	2	clinical	clinical	JJ
cord-006860-a3b8hyyr	2778	3	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2778	4	was	be	VBD
cord-006860-a3b8hyyr	2778	5	excellent	excellent	JJ
cord-006860-a3b8hyyr	2778	6	with	with	IN
cord-006860-a3b8hyyr	2778	7	no	no	DT
cord-006860-a3b8hyyr	2778	8	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2778	9	events	event	NNS
cord-006860-a3b8hyyr	2778	10	.	.	.
cord-006860-a3b8hyyr	2779	1	In	in	IN
cord-006860-a3b8hyyr	2779	2	5	5	CD
cord-006860-a3b8hyyr	2779	3	children	child	NNS
cord-006860-a3b8hyyr	2779	4	with	with	IN
cord-006860-a3b8hyyr	2779	5	vWd	vWd	NNS
cord-006860-a3b8hyyr	2779	6	also	also	RB
cord-006860-a3b8hyyr	2779	7	undergoing	undergo	VBG
cord-006860-a3b8hyyr	2779	8	elective	elective	JJ
cord-006860-a3b8hyyr	2779	9	surgery	surgery	NN
cord-006860-a3b8hyyr	2779	10	continuous	continuous	JJ
cord-006860-a3b8hyyr	2779	11	infusions	infusion	NNS
cord-006860-a3b8hyyr	2779	12	with	with	IN
cord-006860-a3b8hyyr	2779	13	Humate	Humate	NNP
cord-006860-a3b8hyyr	2779	14	pR	pR	,
cord-006860-a3b8hyyr	2779	15	were	be	VBD
cord-006860-a3b8hyyr	2779	16	performed	perform	VBN
cord-006860-a3b8hyyr	2779	17	in	in	IN
cord-006860-a3b8hyyr	2779	18	the	the	DT
cord-006860-a3b8hyyr	2779	19	same	same	JJ
cord-006860-a3b8hyyr	2779	20	way	way	NN
cord-006860-a3b8hyyr	2779	21	.	.	.
cord-006860-a3b8hyyr	2780	1	No	no	DT
cord-006860-a3b8hyyr	2780	2	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2780	3	events	event	NNS
cord-006860-a3b8hyyr	2780	4	were	be	VBD
cord-006860-a3b8hyyr	2780	5	observed	observe	VBN
cord-006860-a3b8hyyr	2780	6	in	in	IN
cord-006860-a3b8hyyr	2780	7	these	these	DT
cord-006860-a3b8hyyr	2780	8	patients	patient	NNS
cord-006860-a3b8hyyr	2780	9	.	.	.
cord-006860-a3b8hyyr	2781	1	None	none	NN
cord-006860-a3b8hyyr	2781	2	of	of	IN
cord-006860-a3b8hyyr	2781	3	the	the	DT
cord-006860-a3b8hyyr	2781	4	patients	patient	NNS
cord-006860-a3b8hyyr	2781	5	developed	develop	VBD
cord-006860-a3b8hyyr	2781	6	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	2781	7	wound	wound	NN
cord-006860-a3b8hyyr	2781	8	infections	infection	NNS
cord-006860-a3b8hyyr	2781	9	.	.	.
cord-006860-a3b8hyyr	2782	1	The	the	DT
cord-006860-a3b8hyyr	2782	2	overall	overall	JJ
cord-006860-a3b8hyyr	2782	3	doses	dose	NNS
cord-006860-a3b8hyyr	2782	4	of	of	IN
cord-006860-a3b8hyyr	2782	5	F	F	NNP
cord-006860-a3b8hyyr	2782	6	Vtll	Vtll	NNP
cord-006860-a3b8hyyr	2782	7	concentrate	concentrate	NN
cord-006860-a3b8hyyr	2782	8	'	'	''
cord-006860-a3b8hyyr	2782	9	were	be	VBD
cord-006860-a3b8hyyr	2782	10	about	about	RB
cord-006860-a3b8hyyr	2782	11	20	20	CD
cord-006860-a3b8hyyr	2782	12	-	-	SYM
cord-006860-a3b8hyyr	2782	13	30	30	CD
cord-006860-a3b8hyyr	2782	14	%	%	NN
cord-006860-a3b8hyyr	2782	15	lower	low	JJR
cord-006860-a3b8hyyr	2782	16	than	than	IN
cord-006860-a3b8hyyr	2782	17	those	those	DT
cord-006860-a3b8hyyr	2782	18	required	require	VBN
cord-006860-a3b8hyyr	2782	19	during	during	IN
cord-006860-a3b8hyyr	2782	20	replacement	replacement	NN
cord-006860-a3b8hyyr	2782	21	therapy	therapy	NN
cord-006860-a3b8hyyr	2782	22	with	with	IN
cord-006860-a3b8hyyr	2782	23	bolus	bolus	NN
cord-006860-a3b8hyyr	2782	24	doses	dose	NNS
cord-006860-a3b8hyyr	2782	25	.	.	.
cord-006860-a3b8hyyr	2782	26	 	 	_SP
cord-006860-a3b8hyyr	2783	1	lg8	lg8	NNP
cord-006860-a3b8hyyr	2783	2	FACTOR	FACTOR	NNP
cord-006860-a3b8hyyr	2783	3	X	X	NNP
cord-006860-a3b8hyyr	2783	4	FRANKFURT	FRANKFURT	NNP
cord-006860-a3b8hyyr	2784	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	2784	2	:	:	:
cord-006860-a3b8hyyr	2784	3	MOLECULAR	molecular	NN
cord-006860-a3b8hyyr	2784	4	AND	and	CC
cord-006860-a3b8hyyr	2784	5	FUNCTIONAL	functional	JJ
cord-006860-a3b8hyyr	2784	6	CHARACTERISATION	CHARACTERISATION	NNS
cord-006860-a3b8hyyr	2784	7	OF	of	IN
cord-006860-a3b8hyyr	2784	8	A	a	DT
cord-006860-a3b8hyyr	2784	9	HEREDITARY	hereditary	JJ
cord-006860-a3b8hyyr	2784	10	FACTOR	factor	NN
cord-006860-a3b8hyyr	2785	1	X	X	NNP
cord-006860-a3b8hyyr	2785	2	DEFECT	DEFECT	NNP
cord-006860-a3b8hyyr	2785	3	(	(	-LRB-
cord-006860-a3b8hyyr	2785	4	GLA	GLA	NNP
cord-006860-a3b8hyyr	2785	5	+25	+25	NNP
cord-006860-a3b8hyyr	2785	6	LYS	LYS	NNP
cord-006860-a3b8hyyr	2785	7	)	)	-RRB-
cord-006860-a3b8hyyr	2786	1	Huhmann	Huhmann	NNP
cord-006860-a3b8hyyr	2786	2	I.	I.	NNP
cord-006860-a3b8hyyr	2786	3	,	,	,
cord-006860-a3b8hyyr	2786	4	HOller	HOller	NNP
cord-006860-a3b8hyyr	2786	5	B.	B.	NNP
cord-006860-a3b8hyyr	2786	6	,	,	,
cord-006860-a3b8hyyr	2786	7	Krinninger	Krinninger	NNP
cord-006860-a3b8hyyr	2786	8	B.	B.	NNP
cord-006860-a3b8hyyr	2786	9	,	,	,
cord-006860-a3b8hyyr	2786	10	Turecek	Turecek	NNP
cord-006860-a3b8hyyr	2786	11	P.L	P.L	NNP
cord-006860-a3b8hyyr	2786	12	,	,	,
cord-006860-a3b8hyyr	2786	13	Richter	Richter	NNP
cord-006860-a3b8hyyr	2786	14	G.	G.	NNP
cord-006860-a3b8hyyr	2786	15	,	,	,
cord-006860-a3b8hyyr	2786	16	Scharrer	Scharrer	NNP
cord-006860-a3b8hyyr	2786	17	I.	I.	NNP
cord-006860-a3b8hyyr	2786	18	,	,	,
cord-006860-a3b8hyyr	2786	19	Forberg	Forberg	NNP
cord-006860-a3b8hyyr	2786	20	E.	E.	NNP
cord-006860-a3b8hyyr	2786	21	,	,	,
cord-006860-a3b8hyyr	2786	22	Watzke	Watzke	NNP
cord-006860-a3b8hyyr	2786	23	H.	H.	NNP
cord-006860-a3b8hyyr	2786	24	Univ	Univ	NNP
cord-006860-a3b8hyyr	2786	25	.	.	.
cord-006860-a3b8hyyr	2787	1	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	2787	2	f0r	f0r	NNP
cord-006860-a3b8hyyr	2788	1	Inhere	Inhere	NNP
cord-006860-a3b8hyyr	2788	2	Med	Med	NNP
cord-006860-a3b8hyyr	2788	3	.	.	.
cord-006860-a3b8hyyr	2789	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	2789	2	,	,	,
cord-006860-a3b8hyyr	2789	3	Abteilung	Abteilung	NNP
cord-006860-a3b8hyyr	2789	4	for	for	IN
cord-006860-a3b8hyyr	2789	5	H	H	NNP
cord-006860-a3b8hyyr	2789	6	~	~	NFP
cord-006860-a3b8hyyr	2789	7	tmatologie	tmatologie	NN
cord-006860-a3b8hyyr	2789	8	und	und	DT
cord-006860-a3b8hyyr	2789	9	H	H	NNP
cord-006860-a3b8hyyr	2789	10	~	~	NFP
cord-006860-a3b8hyyr	2789	11	mostaseologie	mostaseologie	NN
cord-006860-a3b8hyyr	2789	12	,	,	,
cord-006860-a3b8hyyr	2789	13	W	W	NNP
cord-006860-a3b8hyyr	2789	14	~	~	NN
cord-006860-a3b8hyyr	2789	15	en	en	XX
cord-006860-a3b8hyyr	2789	16	;	;	:
cord-006860-a3b8hyyr	2789	17	Immuno	Immuno	NNP
cord-006860-a3b8hyyr	2789	18	-	-	HYPH
cord-006860-a3b8hyyr	2789	19	Ag	Ag	NNP
cord-006860-a3b8hyyr	2789	20	,	,	,
cord-006860-a3b8hyyr	2789	21	Wien	Wien	NNP
cord-006860-a3b8hyyr	2789	22	;	;	:
cord-006860-a3b8hyyr	2789	23	Klinikum	Klinikum	NNP
cord-006860-a3b8hyyr	2789	24	der	der	NNP
cord-006860-a3b8hyyr	2789	25	J.W.	J.W.	NNP
cord-006860-a3b8hyyr	2789	26	Goethe	Goethe	NNP
cord-006860-a3b8hyyr	2789	27	-	-	HYPH
cord-006860-a3b8hyyr	2789	28	Univ	Univ	NNP
cord-006860-a3b8hyyr	2789	29	.	.	.
cord-006860-a3b8hyyr	2790	1	Frankfurt	Frankfurt	NNP
cord-006860-a3b8hyyr	2790	2	am	be	VBP
cord-006860-a3b8hyyr	2790	3	Main	Main	NNP
cord-006860-a3b8hyyr	2790	4	,	,	,
cord-006860-a3b8hyyr	2790	5	Abt	Abt	NNP
cord-006860-a3b8hyyr	2790	6	.	.	.
cord-006860-a3b8hyyr	2790	7	f.	f.	NNP
cord-006860-a3b8hyyr	2790	8	Angiologie	Angiologie	NNP
cord-006860-a3b8hyyr	2790	9	.	.	.
cord-006860-a3b8hyyr	2791	1	Factor	factor	NN
cord-006860-a3b8hyyr	2791	2	X	X	NNP
cord-006860-a3b8hyyr	2791	3	(	(	-LRB-
cord-006860-a3b8hyyr	2791	4	FX	FX	NNP
cord-006860-a3b8hyyr	2791	5	)	)	-RRB-
cord-006860-a3b8hyyr	2791	6	is	be	VBZ
cord-006860-a3b8hyyr	2791	7	a	a	DT
cord-006860-a3b8hyyr	2791	8	Vitamin	vitamin	NN
cord-006860-a3b8hyyr	2791	9	K	k	NN
cord-006860-a3b8hyyr	2791	10	-	-	HYPH
cord-006860-a3b8hyyr	2791	11	dependent	dependent	JJ
cord-006860-a3b8hyyr	2791	12	plasma	plasma	NN
cord-006860-a3b8hyyr	2791	13	protein	protein	NN
cord-006860-a3b8hyyr	2791	14	which	which	WDT
cord-006860-a3b8hyyr	2791	15	is	be	VBZ
cord-006860-a3b8hyyr	2791	16	activated	activate	VBN
cord-006860-a3b8hyyr	2791	17	either	either	CC
cord-006860-a3b8hyyr	2791	18	by	by	IN
cord-006860-a3b8hyyr	2791	19	FVIla	fvila	NN
cord-006860-a3b8hyyr	2791	20	/	/	SYM
cord-006860-a3b8hyyr	2791	21	tissue	tissue	NN
cord-006860-a3b8hyyr	2791	22	factor	factor	NN
cord-006860-a3b8hyyr	2791	23	or	or	CC
cord-006860-a3b8hyyr	2791	24	IXaNIIla	IXaNIIla	NNP
cord-006860-a3b8hyyr	2791	25	.	.	.
cord-006860-a3b8hyyr	2792	1	FXa	FXa	NNP
cord-006860-a3b8hyyr	2792	2	is	be	VBZ
cord-006860-a3b8hyyr	2792	3	the	the	DT
cord-006860-a3b8hyyr	2792	4	main	main	JJ
cord-006860-a3b8hyyr	2792	5	enzyme	enzyme	NN
cord-006860-a3b8hyyr	2792	6	for	for	IN
cord-006860-a3b8hyyr	2792	7	conversion	conversion	NN
cord-006860-a3b8hyyr	2792	8	of	of	IN
cord-006860-a3b8hyyr	2792	9	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	2792	10	to	to	IN
cord-006860-a3b8hyyr	2792	11	thrombin	thrombin	NN
cord-006860-a3b8hyyr	2792	12	.	.	.
cord-006860-a3b8hyyr	2793	1	The	the	DT
cord-006860-a3b8hyyr	2793	2	congenital	congenital	JJ
cord-006860-a3b8hyyr	2793	3	FX	fx	NN
cord-006860-a3b8hyyr	2793	4	-	-	HYPH
cord-006860-a3b8hyyr	2793	5	deficiency	deficiency	NN
cord-006860-a3b8hyyr	2793	6	(	(	-LRB-
cord-006860-a3b8hyyr	2793	7	Stuart	Stuart	NNP
cord-006860-a3b8hyyr	2793	8	-Prower	-prower	NN
cord-006860-a3b8hyyr	2793	9	-	-	HYPH
cord-006860-a3b8hyyr	2793	10	defect	defect	NN
cord-006860-a3b8hyyr	2793	11	)	)	-RRB-
cord-006860-a3b8hyyr	2793	12	being	be	VBG
cord-006860-a3b8hyyr	2793	13	inherited	inherit	VBN
cord-006860-a3b8hyyr	2793	14	as	as	IN
cord-006860-a3b8hyyr	2793	15	an	an	DT
cord-006860-a3b8hyyr	2793	16	autosomal	autosomal	JJ
cord-006860-a3b8hyyr	2793	17	recessive	recessive	JJ
cord-006860-a3b8hyyr	2793	18	trait	trait	NN
cord-006860-a3b8hyyr	2793	19	subsequently	subsequently	RB
cord-006860-a3b8hyyr	2793	20	leads	lead	VBZ
cord-006860-a3b8hyyr	2793	21	to	to	IN
cord-006860-a3b8hyyr	2793	22	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2793	23	diasthesis	diasthesis	NN
cord-006860-a3b8hyyr	2793	24	of	of	IN
cord-006860-a3b8hyyr	2793	25	varying	vary	VBG
cord-006860-a3b8hyyr	2793	26	severity	severity	NN
cord-006860-a3b8hyyr	2793	27	.	.	.
cord-006860-a3b8hyyr	2794	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	2794	2	propositus	propositus	NN
cord-006860-a3b8hyyr	2794	3	is	be	VBZ
cord-006860-a3b8hyyr	2794	4	a	a	DT
cord-006860-a3b8hyyr	2794	5	24	24	CD
cord-006860-a3b8hyyr	2794	6	year	year	NN
cord-006860-a3b8hyyr	2794	7	old	old	JJ
cord-006860-a3b8hyyr	2794	8	patient	patient	NN
cord-006860-a3b8hyyr	2794	9	presenting	present	VBG
cord-006860-a3b8hyyr	2794	10	a	a	DT
cord-006860-a3b8hyyr	2794	11	mild	mild	JJ
cord-006860-a3b8hyyr	2794	12	bleeding	bleeding	NN
cord-006860-a3b8hyyr	2794	13	tendency	tendency	NN
cord-006860-a3b8hyyr	2794	14	.	.	.
cord-006860-a3b8hyyr	2795	1	His	-PRON-	PRP$
cord-006860-a3b8hyyr	2795	2	P'FI	p'fi	NN
cord-006860-a3b8hyyr	2795	3	(	(	-LRB-
cord-006860-a3b8hyyr	2795	4	36	36	CD
cord-006860-a3b8hyyr	2795	5	sec	sec	NNP
cord-006860-a3b8hyyr	2795	6	)	)	-RRB-
cord-006860-a3b8hyyr	2795	7	is	be	VBZ
cord-006860-a3b8hyyr	2795	8	within	within	IN
cord-006860-a3b8hyyr	2795	9	the	the	DT
cord-006860-a3b8hyyr	2795	10	normal	normal	JJ
cord-006860-a3b8hyyr	2795	11	range	range	NN
cord-006860-a3b8hyyr	2795	12	,	,	,
cord-006860-a3b8hyyr	2795	13	the	the	DT
cord-006860-a3b8hyyr	2795	14	PT	pt	NN
cord-006860-a3b8hyyr	2795	15	(	(	-LRB-
cord-006860-a3b8hyyr	2795	16	73	73	CD
cord-006860-a3b8hyyr	2795	17	%	%	NN
cord-006860-a3b8hyyr	2795	18	of	of	IN
cord-006860-a3b8hyyr	2795	19	normal	normal	JJ
cord-006860-a3b8hyyr	2795	20	)	)	-RRB-
cord-006860-a3b8hyyr	2795	21	is	be	VBZ
cord-006860-a3b8hyyr	2795	22	slightly	slightly	RB
cord-006860-a3b8hyyr	2795	23	reduced	reduce	VBN
cord-006860-a3b8hyyr	2795	24	.	.	.
cord-006860-a3b8hyyr	2796	1	The	the	DT
cord-006860-a3b8hyyr	2796	2	Factor	Factor	NNP
cord-006860-a3b8hyyr	2796	3	X	x	NN
cord-006860-a3b8hyyr	2796	4	antigen	antigen	NN
cord-006860-a3b8hyyr	2796	5	level	level	NN
cord-006860-a3b8hyyr	2796	6	is	be	VBZ
cord-006860-a3b8hyyr	2796	7	reduced	reduce	VBN
cord-006860-a3b8hyyr	2796	8	to	to	IN
cord-006860-a3b8hyyr	2796	9	55	55	CD
cord-006860-a3b8hyyr	2796	10	%	%	NN
cord-006860-a3b8hyyr	2796	11	of	of	IN
cord-006860-a3b8hyyr	2796	12	normal	normal	JJ
cord-006860-a3b8hyyr	2796	13	.	.	.
cord-006860-a3b8hyyr	2797	1	Molecular	molecular	JJ
cord-006860-a3b8hyyr	2797	2	charactedsation	charactedsation	NN
cord-006860-a3b8hyyr	2797	3	of	of	IN
cord-006860-a3b8hyyr	2797	4	the	the	DT
cord-006860-a3b8hyyr	2797	5	genetic	genetic	JJ
cord-006860-a3b8hyyr	2797	6	defect	defect	NN
cord-006860-a3b8hyyr	2797	7	was	be	VBD
cord-006860-a3b8hyyr	2797	8	performed	perform	VBN
cord-006860-a3b8hyyr	2797	9	by	by	IN
cord-006860-a3b8hyyr	2797	10	amplification	amplification	NN
cord-006860-a3b8hyyr	2797	11	of	of	IN
cord-006860-a3b8hyyr	2797	12	the	the	DT
cord-006860-a3b8hyyr	2797	13	eight	eight	CD
cord-006860-a3b8hyyr	2797	14	exerts	exert	NNS
cord-006860-a3b8hyyr	2797	15	and	and	CC
cord-006860-a3b8hyyr	2797	16	exonintron	exonintron	NNP
cord-006860-a3b8hyyr	2797	17	junctions	junction	NNS
cord-006860-a3b8hyyr	2797	18	by	by	IN
cord-006860-a3b8hyyr	2797	19	PCR	PCR	NNP
cord-006860-a3b8hyyr	2797	20	and	and	CC
cord-006860-a3b8hyyr	2797	21	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	2797	22	direct	direct	JJ
cord-006860-a3b8hyyr	2797	23	sequencing	sequencing	NN
cord-006860-a3b8hyyr	2797	24	of	of	IN
cord-006860-a3b8hyyr	2797	25	the	the	DT
cord-006860-a3b8hyyr	2797	26	products	product	NNS
cord-006860-a3b8hyyr	2797	27	.	.	.
cord-006860-a3b8hyyr	2798	1	In	in	IN
cord-006860-a3b8hyyr	2798	2	comparison	comparison	NN
cord-006860-a3b8hyyr	2798	3	to	to	IN
cord-006860-a3b8hyyr	2798	4	the	the	DT
cord-006860-a3b8hyyr	2798	5	normal	normal	JJ
cord-006860-a3b8hyyr	2798	6	sequence	sequence	NN
cord-006860-a3b8hyyr	2798	7	we	-PRON-	PRP
cord-006860-a3b8hyyr	2798	8	could	could	MD
cord-006860-a3b8hyyr	2798	9	determine	determine	VB
cord-006860-a3b8hyyr	2798	10	a	a	DT
cord-006860-a3b8hyyr	2798	11	single	single	JJ
cord-006860-a3b8hyyr	2798	12	mismatch	mismatch	NN
cord-006860-a3b8hyyr	2798	13	within	within	IN
cord-006860-a3b8hyyr	2798	14	exon	exon	NN
cord-006860-a3b8hyyr	2798	15	II	II	NNP
cord-006860-a3b8hyyr	2798	16	resulting	result	VBG
cord-006860-a3b8hyyr	2798	17	in	in	IN
cord-006860-a3b8hyyr	2798	18	the	the	DT
cord-006860-a3b8hyyr	2798	19	substitution	substitution	NN
cord-006860-a3b8hyyr	2798	20	of	of	IN
cord-006860-a3b8hyyr	2798	21	+25	+25	NNP
cord-006860-a3b8hyyr	2798	22	Gla	Gla	NNP
cord-006860-a3b8hyyr	2798	23	(	(	-LRB-
cord-006860-a3b8hyyr	2798	24	GAA	GAA	NNP
cord-006860-a3b8hyyr	2798	25	)	)	-RRB-
cord-006860-a3b8hyyr	2798	26	by	by	IN
cord-006860-a3b8hyyr	2798	27	Lys	Lys	NNP
cord-006860-a3b8hyyr	2798	28	(	(	-LRB-
cord-006860-a3b8hyyr	2798	29	AAA	AAA	NNP
cord-006860-a3b8hyyr	2798	30	)	)	-RRB-
cord-006860-a3b8hyyr	2798	31	.	.	.
cord-006860-a3b8hyyr	2799	1	The	the	DT
cord-006860-a3b8hyyr	2799	2	mutation	mutation	NN
cord-006860-a3b8hyyr	2799	3	abolishes	abolish	VBZ
cord-006860-a3b8hyyr	2799	4	a	a	DT
cord-006860-a3b8hyyr	2799	5	naturally	naturally	RB
cord-006860-a3b8hyyr	2799	6	occuring	occur	VBG
cord-006860-a3b8hyyr	2799	7	Mboll	Mboll	NNP
cord-006860-a3b8hyyr	2799	8	site	site	NN
cord-006860-a3b8hyyr	2799	9	in	in	IN
cord-006860-a3b8hyyr	2799	10	the	the	DT
cord-006860-a3b8hyyr	2799	11	DNA	dna	NN
cord-006860-a3b8hyyr	2799	12	sequence	sequence	NN
cord-006860-a3b8hyyr	2799	13	of	of	IN
cord-006860-a3b8hyyr	2799	14	exon	exon	NN
cord-006860-a3b8hyyr	2799	15	II	II	NNP
cord-006860-a3b8hyyr	2799	16	.	.	.
cord-006860-a3b8hyyr	2800	1	The	the	DT
cord-006860-a3b8hyyr	2800	2	status	status	NN
cord-006860-a3b8hyyr	2800	3	of	of	IN
cord-006860-a3b8hyyr	2800	4	the	the	DT
cord-006860-a3b8hyyr	2800	5	FX	FX	NNP
cord-006860-a3b8hyyr	2800	6	encoding	encoding	NN
cord-006860-a3b8hyyr	2800	7	alleles	allele	NNS
cord-006860-a3b8hyyr	2800	8	was	be	VBD
cord-006860-a3b8hyyr	2800	9	determined	determine	VBN
cord-006860-a3b8hyyr	2800	10	in	in	IN
cord-006860-a3b8hyyr	2800	11	the	the	DT
cord-006860-a3b8hyyr	2800	12	propositus	propositus	NN
cord-006860-a3b8hyyr	2800	13	,	,	,
cord-006860-a3b8hyyr	2800	14	his	-PRON-	PRP$
cord-006860-a3b8hyyr	2800	15	mother	mother	NN
cord-006860-a3b8hyyr	2800	16	and	and	CC
cord-006860-a3b8hyyr	2800	17	one	one	CD
cord-006860-a3b8hyyr	2800	18	of	of	IN
cord-006860-a3b8hyyr	2800	19	his	-PRON-	PRP$
cord-006860-a3b8hyyr	2800	20	brothers	brother	NNS
cord-006860-a3b8hyyr	2800	21	by	by	IN
cord-006860-a3b8hyyr	2800	22	amplification	amplification	NN
cord-006860-a3b8hyyr	2800	23	of	of	IN
cord-006860-a3b8hyyr	2800	24	exon	exon	NN
cord-006860-a3b8hyyr	2800	25	II	II	NNP
cord-006860-a3b8hyyr	2800	26	and	and	CC
cord-006860-a3b8hyyr	2800	27	restriction	restriction	NN
cord-006860-a3b8hyyr	2800	28	digest	digest	NN
cord-006860-a3b8hyyr	2800	29	with	with	IN
cord-006860-a3b8hyyr	2800	30	Mboll	Mboll	NNP
cord-006860-a3b8hyyr	2800	31	.	.	.
cord-006860-a3b8hyyr	2801	1	These	these	DT
cord-006860-a3b8hyyr	2801	2	family	family	NN
cord-006860-a3b8hyyr	2801	3	members	member	NNS
cord-006860-a3b8hyyr	2801	4	were	be	VBD
cord-006860-a3b8hyyr	2801	5	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	2801	6	with	with	IN
cord-006860-a3b8hyyr	2801	7	respect	respect	NN
cord-006860-a3b8hyyr	2801	8	to	to	IN
cord-006860-a3b8hyyr	2801	9	the	the	DT
cord-006860-a3b8hyyr	2801	10	mutation	mutation	NN
cord-006860-a3b8hyyr	2801	11	in	in	IN
cord-006860-a3b8hyyr	2801	12	exert	exert	NNP
cord-006860-a3b8hyyr	2801	13	II	II	NNP
cord-006860-a3b8hyyr	2801	14	.	.	.
cord-006860-a3b8hyyr	2802	1	FX	FX	NNP
cord-006860-a3b8hyyr	2802	2	was	be	VBD
cord-006860-a3b8hyyr	2802	3	isolated	isolate	VBN
cord-006860-a3b8hyyr	2802	4	from	from	IN
cord-006860-a3b8hyyr	2802	5	plasma	plasma	NN
cord-006860-a3b8hyyr	2802	6	of	of	IN
cord-006860-a3b8hyyr	2802	7	the	the	DT
cord-006860-a3b8hyyr	2802	8	propositus	propositus	NNP
cord-006860-a3b8hyyr	2802	9	by	by	IN
cord-006860-a3b8hyyr	2802	10	monoq	monoq	NNP
cord-006860-a3b8hyyr	2802	11	ion	ion	NNP
cord-006860-a3b8hyyr	2802	12	exchange	exchange	NN
cord-006860-a3b8hyyr	2802	13	chromatography	chromatography	NN
cord-006860-a3b8hyyr	2802	14	.	.	.
cord-006860-a3b8hyyr	2803	1	Performing	perform	VBG
cord-006860-a3b8hyyr	2803	2	clotting	clotting	NN
cord-006860-a3b8hyyr	2803	3	assays	assay	NNS
cord-006860-a3b8hyyr	2803	4	with	with	IN
cord-006860-a3b8hyyr	2803	5	purified	purify	VBN
cord-006860-a3b8hyyr	2803	6	FX	FX	NNP
cord-006860-a3b8hyyr	2803	7	Frankfurt	Frankfurt	NNP
cord-006860-a3b8hyyr	2804	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	2804	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	2804	3	determined	determine	VBD
cord-006860-a3b8hyyr	2804	4	an	an	DT
cord-006860-a3b8hyyr	2804	5	activity	activity	NN
cord-006860-a3b8hyyr	2804	6	of	of	IN
cord-006860-a3b8hyyr	2804	7	89	89	CD
cord-006860-a3b8hyyr	2804	8	%	%	NN
cord-006860-a3b8hyyr	2804	9	of	of	IN
cord-006860-a3b8hyyr	2804	10	normal	normal	JJ
cord-006860-a3b8hyyr	2804	11	FX	FX	NNP
cord-006860-a3b8hyyr	2804	12	upon	upon	IN
cord-006860-a3b8hyyr	2804	13	activation	activation	NN
cord-006860-a3b8hyyr	2804	14	with	with	IN
cord-006860-a3b8hyyr	2804	15	RW	RW	NNP
cord-006860-a3b8hyyr	2804	16	,	,	,
cord-006860-a3b8hyyr	2804	17	77	77	CD
cord-006860-a3b8hyyr	2804	18	%	%	NN
cord-006860-a3b8hyyr	2804	19	upon	upon	IN
cord-006860-a3b8hyyr	2804	20	intdnsic	intdnsic	NNP
cord-006860-a3b8hyyr	2804	21	activation	activation	NN
cord-006860-a3b8hyyr	2804	22	(	(	-LRB-
cord-006860-a3b8hyyr	2804	23	aPTT	aptt	NN
cord-006860-a3b8hyyr	2804	24	)	)	-RRB-
cord-006860-a3b8hyyr	2804	25	and	and	CC
cord-006860-a3b8hyyr	2804	26	81	81	CD
cord-006860-a3b8hyyr	2804	27	%	%	NN
cord-006860-a3b8hyyr	2804	28	upon	upon	IN
cord-006860-a3b8hyyr	2804	29	extrinsic	extrinsic	JJ
cord-006860-a3b8hyyr	2804	30	activation	activation	NN
cord-006860-a3b8hyyr	2804	31	(	(	-LRB-
cord-006860-a3b8hyyr	2804	32	PT	pt	NN
cord-006860-a3b8hyyr	2804	33	)	)	-RRB-
cord-006860-a3b8hyyr	2804	34	.	.	.
cord-006860-a3b8hyyr	2805	1	This	this	DT
cord-006860-a3b8hyyr	2805	2	compares	compare	VBZ
cord-006860-a3b8hyyr	2805	3	well	well	RB
cord-006860-a3b8hyyr	2805	4	with	with	IN
cord-006860-a3b8hyyr	2805	5	the	the	DT
cord-006860-a3b8hyyr	2805	6	results	result	NNS
cord-006860-a3b8hyyr	2805	7	obtained	obtain	VBN
cord-006860-a3b8hyyr	2805	8	from	from	IN
cord-006860-a3b8hyyr	2805	9	the	the	DT
cord-006860-a3b8hyyr	2805	10	patient	patient	NN
cord-006860-a3b8hyyr	2805	11	plasma	plasma	NN
cord-006860-a3b8hyyr	2805	12	(	(	-LRB-
cord-006860-a3b8hyyr	2805	13	PT	PT	NNP
cord-006860-a3b8hyyr	2805	14	56	56	CD
cord-006860-a3b8hyyr	2805	15	%	%	NN
cord-006860-a3b8hyyr	2805	16	,	,	,
cord-006860-a3b8hyyr	2805	17	PTT	PTT	NNP
cord-006860-a3b8hyyr	2805	18	55	55	CD
cord-006860-a3b8hyyr	2805	19	%	%	NN
cord-006860-a3b8hyyr	2805	20	and	and	CC
cord-006860-a3b8hyyr	2805	21	RW	RW	NNP
cord-006860-a3b8hyyr	2805	22	57	57	CD
cord-006860-a3b8hyyr	2805	23	%	%	NN
cord-006860-a3b8hyyr	2805	24	of	of	IN
cord-006860-a3b8hyyr	2805	25	normal	normal	JJ
cord-006860-a3b8hyyr	2805	26	)	)	-RRB-
cord-006860-a3b8hyyr	2805	27	when	when	WRB
cord-006860-a3b8hyyr	2805	28	the	the	DT
cord-006860-a3b8hyyr	2805	29	reduced	reduce	VBN
cord-006860-a3b8hyyr	2805	30	FX	FX	NNP
cord-006860-a3b8hyyr	2805	31	-	-	HYPH
cord-006860-a3b8hyyr	2805	32	Ag	Ag	NNP
cord-006860-a3b8hyyr	2805	33	-	-	HYPH
cord-006860-a3b8hyyr	2805	34	level	level	NN
cord-006860-a3b8hyyr	2805	35	of	of	IN
cord-006860-a3b8hyyr	2805	36	the	the	DT
cord-006860-a3b8hyyr	2805	37	plasma	plasma	NN
cord-006860-a3b8hyyr	2805	38	(	(	-LRB-
cord-006860-a3b8hyyr	2805	39	55	55	CD
cord-006860-a3b8hyyr	2805	40	%	%	NN
cord-006860-a3b8hyyr	2805	41	)	)	-RRB-
cord-006860-a3b8hyyr	2805	42	is	be	VBZ
cord-006860-a3b8hyyr	2805	43	taken	take	VBN
cord-006860-a3b8hyyr	2805	44	into	into	IN
cord-006860-a3b8hyyr	2805	45	account	account	NN
cord-006860-a3b8hyyr	2805	46	.	.	.
cord-006860-a3b8hyyr	2806	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2806	2	therefore	therefore	RB
cord-006860-a3b8hyyr	2806	3	conclude	conclude	VBP
cord-006860-a3b8hyyr	2806	4	that	that	IN
cord-006860-a3b8hyyr	2806	5	the	the	DT
cord-006860-a3b8hyyr	2806	6	substitution	substitution	NN
cord-006860-a3b8hyyr	2806	7	of	of	IN
cord-006860-a3b8hyyr	2806	8	Gla	Gla	NNP
cord-006860-a3b8hyyr	2806	9	+25	+25	NNP
cord-006860-a3b8hyyr	2806	10	to	to	IN
cord-006860-a3b8hyyr	2806	11	Lys	Lys	NNP
cord-006860-a3b8hyyr	2806	12	results	result	NNS
cord-006860-a3b8hyyr	2806	13	in	in	IN
cord-006860-a3b8hyyr	2806	14	a	a	DT
cord-006860-a3b8hyyr	2806	15	FX	FX	NNP
cord-006860-a3b8hyyr	2806	16	molecule	molecule	NN
cord-006860-a3b8hyyr	2806	17	which	which	WDT
cord-006860-a3b8hyyr	2806	18	is	be	VBZ
cord-006860-a3b8hyyr	2806	19	severely	severely	RB
cord-006860-a3b8hyyr	2806	20	defective	defective	JJ
cord-006860-a3b8hyyr	2806	21	in	in	IN
cord-006860-a3b8hyyr	2806	22	both	both	CC
cord-006860-a3b8hyyr	2806	23	the	the	DT
cord-006860-a3b8hyyr	2806	24	intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	2806	25	and	and	CC
cord-006860-a3b8hyyr	2806	26	extrinsic	extrinsic	JJ
cord-006860-a3b8hyyr	2806	27	pathway	pathway	NN
cord-006860-a3b8hyyr	2806	28	of	of	IN
cord-006860-a3b8hyyr	2806	29	blood	blood	NN
cord-006860-a3b8hyyr	2806	30	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2806	31	.	.	.
cord-006860-a3b8hyyr	2807	1	Bleeding	bleed	VBG
cord-006860-a3b8hyyr	2807	2	after	after	IN
cord-006860-a3b8hyyr	2807	3	cardiothoracic	cardiothoracic	JJ
cord-006860-a3b8hyyr	2807	4	surgery	surgery	NN
cord-006860-a3b8hyyr	2807	5	is	be	VBZ
cord-006860-a3b8hyyr	2807	6	still	still	RB
cord-006860-a3b8hyyr	2807	7	a	a	DT
cord-006860-a3b8hyyr	2807	8	frequent	frequent	JJ
cord-006860-a3b8hyyr	2807	9	,	,	,
cord-006860-a3b8hyyr	2807	10	important	important	JJ
cord-006860-a3b8hyyr	2807	11	and	and	CC
cord-006860-a3b8hyyr	2807	12	sometimes	sometimes	RB
cord-006860-a3b8hyyr	2807	13	life	life	NN
cord-006860-a3b8hyyr	2807	14	-	-	HYPH
cord-006860-a3b8hyyr	2807	15	threatening	threaten	VBG
cord-006860-a3b8hyyr	2807	16	complication	complication	NN
cord-006860-a3b8hyyr	2807	17	.	.	.
cord-006860-a3b8hyyr	2808	1	Thus	thus	RB
cord-006860-a3b8hyyr	2808	2	,	,	,
cord-006860-a3b8hyyr	2808	3	the	the	DT
cord-006860-a3b8hyyr	2808	4	aim	aim	NN
cord-006860-a3b8hyyr	2808	5	of	of	IN
cord-006860-a3b8hyyr	2808	6	this	this	DT
cord-006860-a3b8hyyr	2808	7	study	study	NN
cord-006860-a3b8hyyr	2808	8	was	be	VBD
cord-006860-a3b8hyyr	2808	9	to	to	TO
cord-006860-a3b8hyyr	2808	10	examine	examine	VB
cord-006860-a3b8hyyr	2808	11	routine	routine	JJ
cord-006860-a3b8hyyr	2808	12	parameters	parameter	NNS
cord-006860-a3b8hyyr	2808	13	of	of	IN
cord-006860-a3b8hyyr	2808	14	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	2808	15	and	and	CC
cord-006860-a3b8hyyr	2808	16	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2808	17	predictive	predictive	JJ
cord-006860-a3b8hyyr	2808	18	values	value	NNS
cord-006860-a3b8hyyr	2808	19	for	for	IN
cord-006860-a3b8hyyr	2808	20	severe	severe	JJ
cord-006860-a3b8hyyr	2808	21	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	2808	22	.	.	.
cord-006860-a3b8hyyr	2809	1	This	this	DT
cord-006860-a3b8hyyr	2809	2	prospective	prospective	JJ
cord-006860-a3b8hyyr	2809	3	study	study	NN
cord-006860-a3b8hyyr	2809	4	included	include	VBD
cord-006860-a3b8hyyr	2809	5	patients	patient	NNS
cord-006860-a3b8hyyr	2809	6	undergoing	undergo	VBG
cord-006860-a3b8hyyr	2809	7	cardiopulmonary	cardiopulmonary	JJ
cord-006860-a3b8hyyr	2809	8	bypass	bypass	NN
cord-006860-a3b8hyyr	2809	9	surgery	surgery	NN
cord-006860-a3b8hyyr	2809	10	.	.	.
cord-006860-a3b8hyyr	2810	1	Blood	blood	NN
cord-006860-a3b8hyyr	2810	2	samples	sample	NNS
cord-006860-a3b8hyyr	2810	3	were	be	VBD
cord-006860-a3b8hyyr	2810	4	drawn	draw	VBN
cord-006860-a3b8hyyr	2810	5	preoperatively	preoperatively	RB
cord-006860-a3b8hyyr	2810	6	as	as	RB
cord-006860-a3b8hyyr	2810	7	well	well	RB
cord-006860-a3b8hyyr	2810	8	as	as	IN
cord-006860-a3b8hyyr	2810	9	0	0	CD
cord-006860-a3b8hyyr	2810	10	,	,	,
cord-006860-a3b8hyyr	2810	11	6	6	CD
cord-006860-a3b8hyyr	2810	12	,	,	,
cord-006860-a3b8hyyr	2810	13	18	18	CD
cord-006860-a3b8hyyr	2810	14	hours	hour	NNS
cord-006860-a3b8hyyr	2810	15	and	and	CC
cord-006860-a3b8hyyr	2810	16	2	2	CD
cord-006860-a3b8hyyr	2810	17	,	,	,
cord-006860-a3b8hyyr	2810	18	3	3	CD
cord-006860-a3b8hyyr	2810	19	,	,	,
cord-006860-a3b8hyyr	2810	20	4	4	CD
cord-006860-a3b8hyyr	2810	21	,	,	,
cord-006860-a3b8hyyr	2810	22	5	5	CD
cord-006860-a3b8hyyr	2810	23	,	,	,
cord-006860-a3b8hyyr	2810	24	6	6	CD
cord-006860-a3b8hyyr	2810	25	,	,	,
cord-006860-a3b8hyyr	2810	26	7	7	CD
cord-006860-a3b8hyyr	2810	27	,	,	,
cord-006860-a3b8hyyr	2810	28	8	8	CD
cord-006860-a3b8hyyr	2810	29	days	day	NNS
cord-006860-a3b8hyyr	2810	30	after	after	IN
cord-006860-a3b8hyyr	2810	31	surgery	surgery	NN
cord-006860-a3b8hyyr	2810	32	.	.	.
cord-006860-a3b8hyyr	2811	1	Blood	blood	NN
cord-006860-a3b8hyyr	2811	2	loss	loss	NN
cord-006860-a3b8hyyr	2811	3	from	from	IN
cord-006860-a3b8hyyr	2811	4	drains	drain	NNS
cord-006860-a3b8hyyr	2811	5	,	,	,
cord-006860-a3b8hyyr	2811	6	transfusion	transfusion	NN
cord-006860-a3b8hyyr	2811	7	of	of	IN
cord-006860-a3b8hyyr	2811	8	blood	blood	NN
cord-006860-a3b8hyyr	2811	9	products	product	NNS
cord-006860-a3b8hyyr	2811	10	and	and	CC
cord-006860-a3b8hyyr	2811	11	other	other	JJ
cord-006860-a3b8hyyr	2811	12	important	important	JJ
cord-006860-a3b8hyyr	2811	13	clinical	clinical	JJ
cord-006860-a3b8hyyr	2811	14	data	datum	NNS
cord-006860-a3b8hyyr	2811	15	were	be	VBD
cord-006860-a3b8hyyr	2811	16	monitored	monitor	VBN
cord-006860-a3b8hyyr	2811	17	apart	apart	RB
cord-006860-a3b8hyyr	2811	18	from	from	IN
cord-006860-a3b8hyyr	2811	19	platelet	platelet	NN
cord-006860-a3b8hyyr	2811	20	count	count	NN
cord-006860-a3b8hyyr	2811	21	,	,	,
cord-006860-a3b8hyyr	2811	22	hematocrit	hematocrit	NN
cord-006860-a3b8hyyr	2811	23	,	,	,
cord-006860-a3b8hyyr	2811	24	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	2811	25	time	time	NN
cord-006860-a3b8hyyr	2811	26	,	,	,
cord-006860-a3b8hyyr	2811	27	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	2811	28	time	time	NN
cord-006860-a3b8hyyr	2811	29	,	,	,
cord-006860-a3b8hyyr	2811	30	aPTT	aptt	NN
cord-006860-a3b8hyyr	2811	31	and	and	CC
cord-006860-a3b8hyyr	2811	32	levels	level	NNS
cord-006860-a3b8hyyr	2811	33	of	of	IN
cord-006860-a3b8hyyr	2811	34	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	2811	35	,	,	,
cord-006860-a3b8hyyr	2811	36	ATIII	ATIII	NNP
cord-006860-a3b8hyyr	2811	37	and	and	CC
cord-006860-a3b8hyyr	2811	38	C	C	NNP
cord-006860-a3b8hyyr	2811	39	-	-	HYPH
cord-006860-a3b8hyyr	2811	40	reactive	reactive	JJ
cord-006860-a3b8hyyr	2811	41	protein	protein	NN
cord-006860-a3b8hyyr	2811	42	;	;	:
cord-006860-a3b8hyyr	2811	43	soluble	soluble	JJ
cord-006860-a3b8hyyr	2811	44	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2811	45	(	(	-LRB-
cord-006860-a3b8hyyr	2811	46	SF	SF	NNP
cord-006860-a3b8hyyr	2811	47	)	)	-RRB-
cord-006860-a3b8hyyr	2811	48	was	be	VBD
cord-006860-a3b8hyyr	2811	49	measured	measure	VBN
cord-006860-a3b8hyyr	2811	50	via	via	IN
cord-006860-a3b8hyyr	2811	51	protamine	protamine	NN
cord-006860-a3b8hyyr	2811	52	sulfate	sulfate	NN
cord-006860-a3b8hyyr	2811	53	aggregability	aggregability	NN
cord-006860-a3b8hyyr	2811	54	and	and	CC
cord-006860-a3b8hyyr	2811	55	total	total	NN
cord-006860-a3b8hyyr	2811	56	fibrin(ogen	fibrin(ogen	NN
cord-006860-a3b8hyyr	2811	57	)	)	-RRB-
cord-006860-a3b8hyyr	2811	58	degradation	degradation	NN
cord-006860-a3b8hyyr	2811	59	products	product	NNS
cord-006860-a3b8hyyr	2811	60	(	(	-LRB-
cord-006860-a3b8hyyr	2811	61	FtDP	FtDP	NNP
cord-006860-a3b8hyyr	2811	62	)	)	-RRB-
cord-006860-a3b8hyyr	2811	63	by	by	IN
cord-006860-a3b8hyyr	2811	64	an	an	DT
cord-006860-a3b8hyyr	2811	65	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	2811	66	from	from	IN
cord-006860-a3b8hyyr	2811	67	Organon	Organon	NNP
cord-006860-a3b8hyyr	2811	68	Teknika	Teknika	NNP
cord-006860-a3b8hyyr	2811	69	.	.	.
cord-006860-a3b8hyyr	2812	1	N=	n=	CD
cord-006860-a3b8hyyr	2812	2	109	109	CD
cord-006860-a3b8hyyr	2812	3	patients	patient	NNS
cord-006860-a3b8hyyr	2812	4	were	be	VBD
cord-006860-a3b8hyyr	2812	5	examined	examine	VBN
cord-006860-a3b8hyyr	2812	6	(	(	-LRB-
cord-006860-a3b8hyyr	2812	7	age	age	NN
cord-006860-a3b8hyyr	2812	8	:	:	:
cord-006860-a3b8hyyr	2812	9	64__+9	64__+9	CD
cord-006860-a3b8hyyr	2812	10	y	y	NN
cord-006860-a3b8hyyr	2812	11	)	)	-RRB-
cord-006860-a3b8hyyr	2812	12	.	.	.
cord-006860-a3b8hyyr	2813	1	They	-PRON-	PRP
cord-006860-a3b8hyyr	2813	2	lost	lose	VBD
cord-006860-a3b8hyyr	2813	3	750+__460	750+__460	CD
cord-006860-a3b8hyyr	2813	4	ml	ml	NN
cord-006860-a3b8hyyr	2813	5	blood	blood	NN
cord-006860-a3b8hyyr	2813	6	(	(	-LRB-
cord-006860-a3b8hyyr	2813	7	mean+SD	mean+SD	NNP
cord-006860-a3b8hyyr	2813	8	)	)	-RRB-
cord-006860-a3b8hyyr	2813	9	into	into	IN
cord-006860-a3b8hyyr	2813	10	the	the	DT
cord-006860-a3b8hyyr	2813	11	drains	drain	NNS
cord-006860-a3b8hyyr	2813	12	within	within	IN
cord-006860-a3b8hyyr	2813	13	the	the	DT
cord-006860-a3b8hyyr	2813	14	first	first	JJ
cord-006860-a3b8hyyr	2813	15	18	18	CD
cord-006860-a3b8hyyr	2813	16	hours	hour	NNS
cord-006860-a3b8hyyr	2813	17	after	after	IN
cord-006860-a3b8hyyr	2813	18	end	end	NN
cord-006860-a3b8hyyr	2813	19	of	of	IN
cord-006860-a3b8hyyr	2813	20	surgery	surgery	NN
cord-006860-a3b8hyyr	2813	21	.	.	.
cord-006860-a3b8hyyr	2814	1	A	a	DT
cord-006860-a3b8hyyr	2814	2	severe	severe	JJ
cord-006860-a3b8hyyr	2814	3	bleeding	bleeding	NN
cord-006860-a3b8hyyr	2814	4	was	be	VBD
cord-006860-a3b8hyyr	2814	5	defined	define	VBN
cord-006860-a3b8hyyr	2814	6	to	to	TO
cord-006860-a3b8hyyr	2814	7	exist	exist	VB
cord-006860-a3b8hyyr	2814	8	,	,	,
cord-006860-a3b8hyyr	2814	9	if	if	IN
cord-006860-a3b8hyyr	2814	10	the	the	DT
cord-006860-a3b8hyyr	2814	11	blood	blood	NN
cord-006860-a3b8hyyr	2814	12	loss	loss	NN
cord-006860-a3b8hyyr	2814	13	exceeded	exceed	VBD
cord-006860-a3b8hyyr	2814	14	this	this	DT
cord-006860-a3b8hyyr	2814	15	range	range	NN
cord-006860-a3b8hyyr	2814	16	(	(	-LRB-
cord-006860-a3b8hyyr	2814	17	>	>	NFP
cord-006860-a3b8hyyr	2814	18	1200	1200	CD
cord-006860-a3b8hyyr	2814	19	ml	ml	XX
cord-006860-a3b8hyyr	2814	20	within	within	IN
cord-006860-a3b8hyyr	2814	21	18	18	CD
cord-006860-a3b8hyyr	2814	22	h	h	NN
cord-006860-a3b8hyyr	2814	23	)	)	-RRB-
cord-006860-a3b8hyyr	2814	24	.	.	.
cord-006860-a3b8hyyr	2815	1	Fibrin(ogen	Fibrin(ogen	NNP
cord-006860-a3b8hyyr	2815	2	)	)	-RRB-
cord-006860-a3b8hyyr	2815	3	split	split	NN
cord-006860-a3b8hyyr	2815	4	products	product	NNS
cord-006860-a3b8hyyr	2815	5	proved	prove	VBD
cord-006860-a3b8hyyr	2815	6	to	to	TO
cord-006860-a3b8hyyr	2815	7	be	be	VB
cord-006860-a3b8hyyr	2815	8	a	a	DT
cord-006860-a3b8hyyr	2815	9	useful	useful	JJ
cord-006860-a3b8hyyr	2815	10	parameter	parameter	NN
cord-006860-a3b8hyyr	2815	11	in	in	IN
cord-006860-a3b8hyyr	2815	12	predicting	predict	VBG
cord-006860-a3b8hyyr	2815	13	the	the	DT
cord-006860-a3b8hyyr	2815	14	risk	risk	NN
cord-006860-a3b8hyyr	2815	15	of	of	IN
cord-006860-a3b8hyyr	2815	16	severe	severe	JJ
cord-006860-a3b8hyyr	2815	17	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	2815	18	:	:	:
cord-006860-a3b8hyyr	2815	19	FtDP	FtDP	NNP
cord-006860-a3b8hyyr	2815	20	levels	level	NNS
cord-006860-a3b8hyyr	2815	21	exceeding	exceed	VBG
cord-006860-a3b8hyyr	2815	22	12	12	CD
cord-006860-a3b8hyyr	2815	23	mg	mg	NN
cord-006860-a3b8hyyr	2816	1	/I	/i	NN
cord-006860-a3b8hyyr	2816	2	at	at	IN
cord-006860-a3b8hyyr	2816	3	end	end	NN
cord-006860-a3b8hyyr	2816	4	of	of	IN
cord-006860-a3b8hyyr	2816	5	surgery	surgery	NN
cord-006860-a3b8hyyr	2817	1	(	(	-LRB-
cord-006860-a3b8hyyr	2817	2	n	n	NN
cord-006860-a3b8hyyr	2817	3	=	=	SYM
cord-006860-a3b8hyyr	2817	4	105	105	CD
cord-006860-a3b8hyyr	2817	5	)	)	-RRB-
cord-006860-a3b8hyyr	2817	6	had	have	VBD
cord-006860-a3b8hyyr	2817	7	a	a	DT
cord-006860-a3b8hyyr	2817	8	negative	negative	JJ
cord-006860-a3b8hyyr	2817	9	predictive	predictive	JJ
cord-006860-a3b8hyyr	2817	10	value	value	NN
cord-006860-a3b8hyyr	2817	11	of	of	IN
cord-006860-a3b8hyyr	2817	12	94	94	CD
cord-006860-a3b8hyyr	2817	13	%	%	NN
cord-006860-a3b8hyyr	2817	14	,	,	,
cord-006860-a3b8hyyr	2817	15	positive	positive	JJ
cord-006860-a3b8hyyr	2817	16	predictive	predictive	JJ
cord-006860-a3b8hyyr	2817	17	value	value	NN
cord-006860-a3b8hyyr	2817	18	of	of	IN
cord-006860-a3b8hyyr	2817	19	60	60	CD
cord-006860-a3b8hyyr	2817	20	%	%	NN
cord-006860-a3b8hyyr	2817	21	,	,	,
cord-006860-a3b8hyyr	2817	22	specificity	specificity	NN
cord-006860-a3b8hyyr	2817	23	of	of	IN
cord-006860-a3b8hyyr	2817	24	96	96	CD
cord-006860-a3b8hyyr	2817	25	%	%	NN
cord-006860-a3b8hyyr	2817	26	and	and	CC
cord-006860-a3b8hyyr	2817	27	a	a	DT
cord-006860-a3b8hyyr	2817	28	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	2817	29	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2817	30	of	of	IN
cord-006860-a3b8hyyr	2817	31	91	91	CD
cord-006860-a3b8hyyr	2817	32	%	%	NN
cord-006860-a3b8hyyr	2817	33	.	.	.
cord-006860-a3b8hyyr	2818	1	In	in	IN
cord-006860-a3b8hyyr	2818	2	contrast	contrast	NN
cord-006860-a3b8hyyr	2818	3	,	,	,
cord-006860-a3b8hyyr	2818	4	soluble	soluble	JJ
cord-006860-a3b8hyyr	2818	5	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2818	6	which	which	WDT
cord-006860-a3b8hyyr	2818	7	correlated	correlate	VBD
cord-006860-a3b8hyyr	2818	8	well	well	RB
cord-006860-a3b8hyyr	2818	9	with	with	IN
cord-006860-a3b8hyyr	2818	10	fibrinopeptideA	fibrinopeptideA	NNP
cord-006860-a3b8hyyr	2818	11	(	(	-LRB-
cord-006860-a3b8hyyr	2818	12	r>0.91	r>0.91	NNP
cord-006860-a3b8hyyr	2818	13	,	,	,
cord-006860-a3b8hyyr	2818	14	n=	n=	NNP
cord-006860-a3b8hyyr	2818	15	20	20	CD
cord-006860-a3b8hyyr	2818	16	)	)	-RRB-
cord-006860-a3b8hyyr	2818	17	did	do	VBD
cord-006860-a3b8hyyr	2818	18	not	not	RB
cord-006860-a3b8hyyr	2818	19	correlate	correlate	VB
cord-006860-a3b8hyyr	2818	20	neither	neither	CC
cord-006860-a3b8hyyr	2818	21	with	with	IN
cord-006860-a3b8hyyr	2818	22	degradation	degradation	NN
cord-006860-a3b8hyyr	2818	23	products	product	NNS
cord-006860-a3b8hyyr	2818	24	nor	nor	CC
cord-006860-a3b8hyyr	2818	25	with	with	IN
cord-006860-a3b8hyyr	2818	26	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2818	27	complications	complication	NNS
cord-006860-a3b8hyyr	2818	28	(	(	-LRB-
cord-006860-a3b8hyyr	2818	29	n	n	NN
cord-006860-a3b8hyyr	2818	30	=	=	SYM
cord-006860-a3b8hyyr	2818	31	109	109	CD
cord-006860-a3b8hyyr	2818	32	)	)	-RRB-
cord-006860-a3b8hyyr	2818	33	.	.	.
cord-006860-a3b8hyyr	2819	1	This	this	DT
cord-006860-a3b8hyyr	2819	2	observation	observation	NN
cord-006860-a3b8hyyr	2819	3	does	do	VBZ
cord-006860-a3b8hyyr	2819	4	not	not	RB
cord-006860-a3b8hyyr	2819	5	match	match	VB
cord-006860-a3b8hyyr	2819	6	to	to	IN
cord-006860-a3b8hyyr	2819	7	the	the	DT
cord-006860-a3b8hyyr	2819	8	correspondence	correspondence	NN
cord-006860-a3b8hyyr	2819	9	of	of	IN
cord-006860-a3b8hyyr	2819	10	SF	SF	NNP
cord-006860-a3b8hyyr	2819	11	with	with	IN
cord-006860-a3b8hyyr	2819	12	organ	organ	NN
cord-006860-a3b8hyyr	2819	13	dysfunction	dysfunction	NN
cord-006860-a3b8hyyr	2819	14	during	during	IN
cord-006860-a3b8hyyr	2819	15	DIC	DIC	NNP
cord-006860-a3b8hyyr	2819	16	:	:	:
cord-006860-a3b8hyyr	2819	17	SF	SF	NNP
cord-006860-a3b8hyyr	2819	18	reached	reach	VBD
cord-006860-a3b8hyyr	2819	19	a	a	DT
cord-006860-a3b8hyyr	2819	20	neg.predictive	neg.predictive	NNP
cord-006860-a3b8hyyr	2819	21	value	value	NN
cord-006860-a3b8hyyr	2819	22	near	near	IN
cord-006860-a3b8hyyr	2819	23	95	95	CD
cord-006860-a3b8hyyr	2819	24	%	%	NN
cord-006860-a3b8hyyr	2819	25	and	and	CC
cord-006860-a3b8hyyr	2819	26	a	a	DT
cord-006860-a3b8hyyr	2819	27	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	2819	28	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2819	29	of	of	IN
cord-006860-a3b8hyyr	2819	30	>	>	$
cord-006860-a3b8hyyr	2819	31	70	70	CD
cord-006860-a3b8hyyr	2819	32	%	%	NN
cord-006860-a3b8hyyr	2819	33	(	(	-LRB-
cord-006860-a3b8hyyr	2819	34	pat	pat	NNP
cord-006860-a3b8hyyr	2819	35	.	.	.
cord-006860-a3b8hyyr	2820	1	without	without	IN
cord-006860-a3b8hyyr	2820	2	antifibrinolytic	antifibrinolytic	JJ
cord-006860-a3b8hyyr	2820	3	drugs	drug	NNS
cord-006860-a3b8hyyr	2820	4	)	)	-RRB-
cord-006860-a3b8hyyr	2820	5	,	,	,
cord-006860-a3b8hyyr	2820	6	which	which	WDT
cord-006860-a3b8hyyr	2820	7	complies	comply	VBZ
cord-006860-a3b8hyyr	2820	8	to	to	IN
cord-006860-a3b8hyyr	2820	9	findings	finding	NNS
cord-006860-a3b8hyyr	2820	10	from	from	IN
cord-006860-a3b8hyyr	2820	11	BREDBACKA	BREDBACKA	NNP
cord-006860-a3b8hyyr	2820	12	(	(	-LRB-
cord-006860-a3b8hyyr	2820	13	1994	1994	CD
cord-006860-a3b8hyyr	2820	14	)	)	-RRB-
cord-006860-a3b8hyyr	2820	15	.	.	.
cord-006860-a3b8hyyr	2821	1	Other	other	JJ
cord-006860-a3b8hyyr	2821	2	parameters	parameter	NNS
cord-006860-a3b8hyyr	2821	3	were	be	VBD
cord-006860-a3b8hyyr	2821	4	less	less	RBR
cord-006860-a3b8hyyr	2821	5	predictive	predictive	JJ
cord-006860-a3b8hyyr	2821	6	than	than	IN
cord-006860-a3b8hyyr	2821	7	FtDP	FtDP	NNP
cord-006860-a3b8hyyr	2821	8	and	and	CC
cord-006860-a3b8hyyr	2821	9	SF	SF	NNP
cord-006860-a3b8hyyr	2821	10	.	.	.
cord-006860-a3b8hyyr	2822	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	2822	2	,	,	,
cord-006860-a3b8hyyr	2822	3	further	further	JJ
cord-006860-a3b8hyyr	2822	4	examinations	examination	NNS
cord-006860-a3b8hyyr	2822	5	are	be	VBP
cord-006860-a3b8hyyr	2822	6	necessary	necessary	JJ
cord-006860-a3b8hyyr	2822	7	to	to	TO
cord-006860-a3b8hyyr	2822	8	determine	determine	VB
cord-006860-a3b8hyyr	2822	9	the	the	DT
cord-006860-a3b8hyyr	2822	10	value	value	NN
cord-006860-a3b8hyyr	2822	11	of	of	IN
cord-006860-a3b8hyyr	2822	12	soluble	soluble	JJ
cord-006860-a3b8hyyr	2822	13	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2822	14	for	for	IN
cord-006860-a3b8hyyr	2822	15	a	a	DT
cord-006860-a3b8hyyr	2822	16	risk	risk	NN
cord-006860-a3b8hyyr	2822	17	prediction	prediction	NN
cord-006860-a3b8hyyr	2822	18	of	of	IN
cord-006860-a3b8hyyr	2822	19	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2822	20	complications	complication	NNS
cord-006860-a3b8hyyr	2822	21	or	or	CC
cord-006860-a3b8hyyr	2822	22	DIC	DIC	NNP
cord-006860-a3b8hyyr	2822	23	.	.	.
cord-006860-a3b8hyyr	2823	1	A	a	DT
cord-006860-a3b8hyyr	2823	2	differentiation	differentiation	NN
cord-006860-a3b8hyyr	2823	3	of	of	IN
cord-006860-a3b8hyyr	2823	4	splits	split	NNS
cord-006860-a3b8hyyr	2823	5	products	product	NNS
cord-006860-a3b8hyyr	2823	6	deriving	derive	VBG
cord-006860-a3b8hyyr	2823	7	from	from	IN
cord-006860-a3b8hyyr	2823	8	either	either	CC
cord-006860-a3b8hyyr	2823	9	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	2823	10	,	,	,
cord-006860-a3b8hyyr	2823	11	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2823	12	or	or	CC
cord-006860-a3b8hyyr	2823	13	XL	XL	NNP
cord-006860-a3b8hyyr	2823	14	-	-	HYPH
cord-006860-a3b8hyyr	2823	15	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2823	16	will	will	MD
cord-006860-a3b8hyyr	2823	17	provide	provide	VB
cord-006860-a3b8hyyr	2823	18	further	further	JJ
cord-006860-a3b8hyyr	2823	19	insights	insight	NNS
cord-006860-a3b8hyyr	2823	20	into	into	IN
cord-006860-a3b8hyyr	2823	21	fibrin(ogen	fibrin(ogen	NN
cord-006860-a3b8hyyr	2823	22	)	)	-RRB-
cord-006860-a3b8hyyr	2823	23	metabolism	metabolism	NN
cord-006860-a3b8hyyr	2823	24	.	.	.
cord-006860-a3b8hyyr	2824	1	Heparin	heparin	NN
cord-006860-a3b8hyyr	2824	2	induced	induce	VBN
cord-006860-a3b8hyyr	2824	3	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2824	4	represents	represent	VBZ
cord-006860-a3b8hyyr	2824	5	a	a	DT
cord-006860-a3b8hyyr	2824	6	multicomponent	multicomponent	NN
cord-006860-a3b8hyyr	2824	7	syndrome	syndrome	NN
cord-006860-a3b8hyyr	2824	8	associated	associate	VBN
cord-006860-a3b8hyyr	2824	9	with	with	IN
cord-006860-a3b8hyyr	2824	10	the	the	DT
cord-006860-a3b8hyyr	2824	11	use	use	NN
cord-006860-a3b8hyyr	2824	12	of	of	IN
cord-006860-a3b8hyyr	2824	13	heparin	heparin	NN
cord-006860-a3b8hyyr	2824	14	and	and	CC
cord-006860-a3b8hyyr	2824	15	related	related	JJ
cord-006860-a3b8hyyr	2824	16	drugs	drug	NNS
cord-006860-a3b8hyyr	2824	17	resulting	result	VBG
cord-006860-a3b8hyyr	2824	18	in	in	IN
cord-006860-a3b8hyyr	2824	19	not	not	RB
cord-006860-a3b8hyyr	2824	20	only	only	RB
cord-006860-a3b8hyyr	2824	21	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2824	22	,	,	,
cord-006860-a3b8hyyr	2824	23	but	but	CC
cord-006860-a3b8hyyr	2824	24	also	also	RB
cord-006860-a3b8hyyr	2824	25	arterial	arterial	JJ
cord-006860-a3b8hyyr	2824	26	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2824	27	of	of	IN
cord-006860-a3b8hyyr	2824	28	varying	vary	VBG
cord-006860-a3b8hyyr	2824	29	magnitude	magnitude	NN
cord-006860-a3b8hyyr	2824	30	.	.	.
cord-006860-a3b8hyyr	2825	1	The	the	DT
cord-006860-a3b8hyyr	2825	2	initial	initial	JJ
cord-006860-a3b8hyyr	2825	3	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	2825	4	ofthis	ofthis	NN
cord-006860-a3b8hyyr	2825	5	syndrome	syndrome	NN
cord-006860-a3b8hyyr	2825	6	is	be	VBZ
cord-006860-a3b8hyyr	2825	7	usually	usually	RB
cord-006860-a3b8hyyr	2825	8	made	make	VBN
cord-006860-a3b8hyyr	2825	9	by	by	IN
cord-006860-a3b8hyyr	2825	10	clinical	clinical	JJ
cord-006860-a3b8hyyr	2825	11	observation	observation	NN
cord-006860-a3b8hyyr	2825	12	and	and	CC
cord-006860-a3b8hyyr	2825	13	a	a	DT
cord-006860-a3b8hyyr	2825	14	drop	drop	NN
cord-006860-a3b8hyyr	2825	15	in	in	IN
cord-006860-a3b8hyyr	2825	16	platelet	platelet	NN
cord-006860-a3b8hyyr	2825	17	count	count	NN
cord-006860-a3b8hyyr	2825	18	.	.	.
cord-006860-a3b8hyyr	2826	1	Conventional	conventional	JJ
cord-006860-a3b8hyyr	2826	2	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	2826	3	methods	method	NNS
cord-006860-a3b8hyyr	2826	4	include	include	VBP
cord-006860-a3b8hyyr	2826	5	platelet	platelet	NN
cord-006860-a3b8hyyr	2826	6	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2826	7	responses	response	NNS
cord-006860-a3b8hyyr	2826	8	to	to	TO
cord-006860-a3b8hyyr	2826	9	patient	patient	VB
cord-006860-a3b8hyyr	2826	10	's	's	POS
cord-006860-a3b8hyyr	2826	11	serum	serum	NN
cord-006860-a3b8hyyr	2826	12	and	and	CC
cord-006860-a3b8hyyr	2827	1	~4C	~4C	NNP
cord-006860-a3b8hyyr	2828	1	serotonin	serotonin	NN
cord-006860-a3b8hyyr	2828	2	release	release	NN
cord-006860-a3b8hyyr	2828	3	in	in	IN
cord-006860-a3b8hyyr	2828	4	response	response	NN
cord-006860-a3b8hyyr	2828	5	to	to	TO
cord-006860-a3b8hyyr	2828	6	patient	patient	NN
cord-006860-a3b8hyyr	2828	7	's	's	POS
cord-006860-a3b8hyyr	2828	8	serum	serum	NN
cord-006860-a3b8hyyr	2828	9	,	,	,
cord-006860-a3b8hyyr	2828	10	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2828	11	/	/	SYM
cord-006860-a3b8hyyr	2828	12	agglutination	agglutination	NN
cord-006860-a3b8hyyr	2828	13	of	of	IN
cord-006860-a3b8hyyr	2828	14	patient	patient	NN
cord-006860-a3b8hyyr	2828	15	's	's	POS
cord-006860-a3b8hyyr	2828	16	platdets	platdet	NNS
cord-006860-a3b8hyyr	2828	17	in	in	IN
cord-006860-a3b8hyyr	2828	18	response	response	NN
cord-006860-a3b8hyyr	2828	19	to	to	IN
cord-006860-a3b8hyyr	2828	20	heparins	heparins	NNP
cord-006860-a3b8hyyr	2828	21	and	and	CC
cord-006860-a3b8hyyr	2828	22	the	the	DT
cord-006860-a3b8hyyr	2828	23	detection	detection	NN
cord-006860-a3b8hyyr	2828	24	of	of	IN
cord-006860-a3b8hyyr	2828	25	patients	patient	NNS
cord-006860-a3b8hyyr	2828	26	anti	anti	JJ
cord-006860-a3b8hyyr	2828	27	-	-	JJ
cord-006860-a3b8hyyr	2828	28	heparin	heparin	JJ
cord-006860-a3b8hyyr	2828	29	platelet	platelet	NN
cord-006860-a3b8hyyr	2828	30	factor	factor	NN
cord-006860-a3b8hyyr	2828	31	4	4	CD
cord-006860-a3b8hyyr	2828	32	(	(	-LRB-
cord-006860-a3b8hyyr	2828	33	HPF4-AB	HPF4-AB	NNP
cord-006860-a3b8hyyr	2828	34	)	)	-RRB-
cord-006860-a3b8hyyr	2828	35	ned	ned	NN
cord-006860-a3b8hyyr	2828	36	-	-	HYPH
cord-006860-a3b8hyyr	2828	37	antibodies	antibody	NNS
cord-006860-a3b8hyyr	2828	38	by	by	IN
cord-006860-a3b8hyyr	2828	39	using	use	VBG
cord-006860-a3b8hyyr	2828	40	Elisa	Elisa	NNP
cord-006860-a3b8hyyr	2828	41	methodology	methodology	NN
cord-006860-a3b8hyyr	2828	42	.	.	.
cord-006860-a3b8hyyr	2829	1	Several	several	JJ
cord-006860-a3b8hyyr	2829	2	other	other	JJ
cord-006860-a3b8hyyr	2829	3	individualized	individualized	JJ
cord-006860-a3b8hyyr	2829	4	methods	method	NNS
cord-006860-a3b8hyyr	2829	5	are	be	VBP
cord-006860-a3b8hyyr	2829	6	also	also	RB
cord-006860-a3b8hyyr	2829	7	used	use	VBN
cord-006860-a3b8hyyr	2829	8	to	to	TO
cord-006860-a3b8hyyr	2829	9	demonstrate	demonstrate	VB
cord-006860-a3b8hyyr	2829	10	platelet	platelet	NN
cord-006860-a3b8hyyr	2829	11	activation	activation	NN
cord-006860-a3b8hyyr	2829	12	.	.	.
cord-006860-a3b8hyyr	2830	1	To	to	TO
cord-006860-a3b8hyyr	2830	2	test	test	VB
cord-006860-a3b8hyyr	2830	3	the	the	DT
cord-006860-a3b8hyyr	2830	4	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	2830	5	validity	validity	NN
cord-006860-a3b8hyyr	2830	6	of	of	IN
cord-006860-a3b8hyyr	2830	7	the	the	DT
cord-006860-a3b8hyyr	2830	8	platelet	platelet	NN
cord-006860-a3b8hyyr	2830	9	aggregation	aggregation	NN
cord-006860-a3b8hyyr	2830	10	(	(	-LRB-
cord-006860-a3b8hyyr	2830	11	PA	PA	NNP
cord-006860-a3b8hyyr	2830	12	)	)	-RRB-
cord-006860-a3b8hyyr	2830	13	14C	14c	JJ
cord-006860-a3b8hyyr	2830	14	serotonin	serotonin	NN
cord-006860-a3b8hyyr	2830	15	release	release	NN
cord-006860-a3b8hyyr	2830	16	(	(	-LRB-
cord-006860-a3b8hyyr	2830	17	SR	SR	NNP
cord-006860-a3b8hyyr	2830	18	)	)	-RRB-
cord-006860-a3b8hyyr	2830	19	and	and	CC
cord-006860-a3b8hyyr	2830	20	the	the	DT
cord-006860-a3b8hyyr	2830	21	relevance	relevance	NN
cord-006860-a3b8hyyr	2830	22	of	of	IN
cord-006860-a3b8hyyr	2830	23	HPF~-AB	hpf~-ab	CD
cord-006860-a3b8hyyr	2830	24	340	340	CD
cord-006860-a3b8hyyr	2830	25	serum	serum	NN
cord-006860-a3b8hyyr	2830	26	samples	sample	NNS
cord-006860-a3b8hyyr	2830	27	collected	collect	VBN
cord-006860-a3b8hyyr	2830	28	from	from	IN
cord-006860-a3b8hyyr	2830	29	patients	patient	NNS
cord-006860-a3b8hyyr	2830	30	with	with	IN
cord-006860-a3b8hyyr	2830	31	clinically	clinically	RB
cord-006860-a3b8hyyr	2830	32	eunfwmed	eunfwmed	JJ
cord-006860-a3b8hyyr	2830	33	eases	ease	NNS
cord-006860-a3b8hyyr	2830	34	of	of	IN
cord-006860-a3b8hyyr	2830	35	lilT	lilT	NNS
cord-006860-a3b8hyyr	2830	36	syndrome	syndrome	NN
cord-006860-a3b8hyyr	2830	37	were	be	VBD
cord-006860-a3b8hyyr	2830	38	compared	compare	VBN
cord-006860-a3b8hyyr	2830	39	in	in	IN
cord-006860-a3b8hyyr	2830	40	parallel	parallel	NN
cord-006860-a3b8hyyr	2830	41	in	in	IN
cord-006860-a3b8hyyr	2830	42	various	various	JJ
cord-006860-a3b8hyyr	2830	43	assay	assay	NN
cord-006860-a3b8hyyr	2830	44	systems	system	NNS
cord-006860-a3b8hyyr	2830	45	.	.	.
cord-006860-a3b8hyyr	2831	1	The	the	DT
cord-006860-a3b8hyyr	2831	2	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	2831	3	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2831	4	of	of	IN
cord-006860-a3b8hyyr	2831	5	these	these	DT
cord-006860-a3b8hyyr	2831	6	tests	test	NNS
cord-006860-a3b8hyyr	2831	7	varied	vary	VBN
cord-006860-a3b8hyyr	2831	8	from	from	IN
cord-006860-a3b8hyyr	2831	9	60	60	CD
cord-006860-a3b8hyyr	2831	10	-	-	SYM
cord-006860-a3b8hyyr	2831	11	74	74	CD
cord-006860-a3b8hyyr	2831	12	%	%	NN
cord-006860-a3b8hyyr	2831	13	with	with	IN
cord-006860-a3b8hyyr	2831	14	the	the	DT
cord-006860-a3b8hyyr	2831	15	PA	PA	NNP
cord-006860-a3b8hyyr	2831	16	test	test	NN
cord-006860-a3b8hyyr	2831	17	providing	provide	VBG
cord-006860-a3b8hyyr	2831	18	better	well	JJR
cord-006860-a3b8hyyr	2831	19	results	result	NNS
cord-006860-a3b8hyyr	2831	20	than	than	IN
cord-006860-a3b8hyyr	2831	21	others	other	NNS
cord-006860-a3b8hyyr	2831	22	.	.	.
cord-006860-a3b8hyyr	2832	1	When	when	WRB
cord-006860-a3b8hyyr	2832	2	the	the	DT
cord-006860-a3b8hyyr	2832	3	PA	PA	NNP
cord-006860-a3b8hyyr	2832	4	test	test	NN
cord-006860-a3b8hyyr	2832	5	was	be	VBD
cord-006860-a3b8hyyr	2832	6	compared	compare	VBN
cord-006860-a3b8hyyr	2832	7	with	with	IN
cord-006860-a3b8hyyr	2832	8	serotonin	serotonin	NN
cord-006860-a3b8hyyr	2832	9	release	release	NN
cord-006860-a3b8hyyr	2832	10	,	,	,
cord-006860-a3b8hyyr	2832	11	a	a	DT
cord-006860-a3b8hyyr	2832	12	poor	poor	JJ
cord-006860-a3b8hyyr	2832	13	correlation	correlation	NN
cord-006860-a3b8hyyr	2832	14	was	be	VBD
cord-006860-a3b8hyyr	2832	15	noted	note	VBN
cord-006860-a3b8hyyr	2832	16	(	(	-LRB-
cord-006860-a3b8hyyr	2832	17	r=0.47	r=0.47	NNP
cord-006860-a3b8hyyr	2832	18	)	)	-RRB-
cord-006860-a3b8hyyr	2832	19	.	.	.
cord-006860-a3b8hyyr	2833	1	In	in	IN
cord-006860-a3b8hyyr	2833	2	contrast	contrast	NN
cord-006860-a3b8hyyr	2833	3	,	,	,
cord-006860-a3b8hyyr	2833	4	the	the	DT
cord-006860-a3b8hyyr	2833	5	correlation	correlation	NN
cord-006860-a3b8hyyr	2833	6	between	between	IN
cord-006860-a3b8hyyr	2833	7	the	the	DT
cord-006860-a3b8hyyr	2833	8	PA	PA	NNP
cord-006860-a3b8hyyr	2833	9	and	and	CC
cord-006860-a3b8hyyr	2833	10	HP4-AB	HP4-AB	NNP
cord-006860-a3b8hyyr	2833	11	was	be	VBD
cord-006860-a3b8hyyr	2833	12	somewhat	somewhat	RB
cord-006860-a3b8hyyr	2833	13	better	well	JJR
cord-006860-a3b8hyyr	2833	14	(	(	-LRB-
cord-006860-a3b8hyyr	2833	15	r=0.66	r=0.66	NNP
cord-006860-a3b8hyyr	2833	16	)	)	-RRB-
cord-006860-a3b8hyyr	2833	17	.	.	.
cord-006860-a3b8hyyr	2834	1	In	in	IN
cord-006860-a3b8hyyr	2834	2	another	another	DT
cord-006860-a3b8hyyr	2834	3	study	study	NN
cord-006860-a3b8hyyr	2834	4	,	,	,
cord-006860-a3b8hyyr	2834	5	blood	blood	NN
cord-006860-a3b8hyyr	2834	6	samples	sample	NNS
cord-006860-a3b8hyyr	2834	7	collected	collect	VBN
cord-006860-a3b8hyyr	2834	8	from	from	IN
cord-006860-a3b8hyyr	2834	9	50	50	CD
cord-006860-a3b8hyyr	2834	10	patients	patient	NNS
cord-006860-a3b8hyyr	2834	11	treated	treat	VBN
cord-006860-a3b8hyyr	2834	12	with	with	IN
cord-006860-a3b8hyyr	2834	13	ahigh	ahigh	NN
cord-006860-a3b8hyyr	2834	14	dose	dose	NN
cord-006860-a3b8hyyr	2834	15	low	low	JJ
cord-006860-a3b8hyyr	2834	16	molecular	molecular	JJ
cord-006860-a3b8hyyr	2834	17	weight	weight	NN
cord-006860-a3b8hyyr	2834	18	beparin	beparin	NN
cord-006860-a3b8hyyr	2834	19	for	for	IN
cord-006860-a3b8hyyr	2834	20	two	two	CD
cord-006860-a3b8hyyr	2834	21	weeks	week	NNS
cord-006860-a3b8hyyr	2834	22	(	(	-LRB-
cord-006860-a3b8hyyr	2834	23	80	80	CD
cord-006860-a3b8hyyr	2834	24	mg	mg	NNP
cord-006860-a3b8hyyr	2834	25	O.D.	O.D.	NNP
cord-006860-a3b8hyyr	2834	26	)	)	-RRB-
cord-006860-a3b8hyyr	2834	27	were	be	VBD
cord-006860-a3b8hyyr	2834	28	tested	test	VBN
cord-006860-a3b8hyyr	2834	29	.	.	.
cord-006860-a3b8hyyr	2835	1	20	20	CD
cord-006860-a3b8hyyr	2835	2	of	of	IN
cord-006860-a3b8hyyr	2835	3	these	these	DT
cord-006860-a3b8hyyr	2835	4	patients	patient	NNS
cord-006860-a3b8hyyr	2835	5	showed	show	VBD
cord-006860-a3b8hyyr	2835	6	a	a	DT
cord-006860-a3b8hyyr	2835	7	high	high	JJ
cord-006860-a3b8hyyr	2835	8	titre	titre	NN
cord-006860-a3b8hyyr	2835	9	of	of	IN
cord-006860-a3b8hyyr	2835	10	HPF4.AB	HPF4.AB	NNP
cord-006860-a3b8hyyr	2835	11	without	without	IN
cord-006860-a3b8hyyr	2835	12	any	any	DT
cord-006860-a3b8hyyr	2835	13	decrease	decrease	NN
cord-006860-a3b8hyyr	2835	14	of	of	IN
cord-006860-a3b8hyyr	2835	15	platelet	platelet	NN
cord-006860-a3b8hyyr	2835	16	count	count	NN
cord-006860-a3b8hyyr	2835	17	.	.	.
cord-006860-a3b8hyyr	2836	1	None	none	NN
cord-006860-a3b8hyyr	2836	2	of	of	IN
cord-006860-a3b8hyyr	2836	3	these	these	DT
cord-006860-a3b8hyyr	2836	4	patients	patient	NNS
cord-006860-a3b8hyyr	2836	5	were	be	VBD
cord-006860-a3b8hyyr	2836	6	found	find	VBN
cord-006860-a3b8hyyr	2836	7	to	to	TO
cord-006860-a3b8hyyr	2836	8	be	be	VB
cord-006860-a3b8hyyr	2836	9	positive	positive	JJ
cord-006860-a3b8hyyr	2836	10	in	in	IN
cord-006860-a3b8hyyr	2836	11	the	the	DT
cord-006860-a3b8hyyr	2836	12	14C	14c	JJ
cord-006860-a3b8hyyr	2836	13	serotonin	serotonin	NN
cord-006860-a3b8hyyr	2836	14	release	release	NN
cord-006860-a3b8hyyr	2836	15	assay	assay	NN
cord-006860-a3b8hyyr	2836	16	.	.	.
cord-006860-a3b8hyyr	2837	1	A	a	DT
cord-006860-a3b8hyyr	2837	2	third	third	JJ
cord-006860-a3b8hyyr	2837	3	study	study	NN
cord-006860-a3b8hyyr	2837	4	included	include	VBD
cord-006860-a3b8hyyr	2837	5	blood	blood	NN
cord-006860-a3b8hyyr	2837	6	samples	sample	NNS
cord-006860-a3b8hyyr	2837	7	from	from	IN
cord-006860-a3b8hyyr	2837	8	DVT	DVT	NNP
cord-006860-a3b8hyyr	2837	9	patients	patient	NNS
cord-006860-a3b8hyyr	2837	10	administered	administer	VBN
cord-006860-a3b8hyyr	2837	11	with	with	IN
cord-006860-a3b8hyyr	2837	12	IV	IV	NNP
cord-006860-a3b8hyyr	2837	13	heparin	heparin	JJ
cord-006860-a3b8hyyr	2837	14	infusion	infusion	NN
cord-006860-a3b8hyyr	2837	15	,	,	,
cord-006860-a3b8hyyr	2837	16	high	high	JJ
cord-006860-a3b8hyyr	2837	17	dose	dose	NN
cord-006860-a3b8hyyr	2837	18	SC	SC	NNP
cord-006860-a3b8hyyr	2837	19	LMW	lmw	NN
cord-006860-a3b8hyyr	2837	20	heparin	heparin	NN
cord-006860-a3b8hyyr	2837	21	(	(	-LRB-
cord-006860-a3b8hyyr	2837	22	Certoparin	Certoparin	NNP
cord-006860-a3b8hyyr	2837	23	)	)	-RRB-
cord-006860-a3b8hyyr	2837	24	and	and	CC
cord-006860-a3b8hyyr	2837	25	IV	IV	NNP
cord-006860-a3b8hyyr	2837	26	LMW	LMW	NNP
cord-006860-a3b8hyyr	2837	27	heparin	heparin	JJ
cord-006860-a3b8hyyr	2837	28	for	for	IN
cord-006860-a3b8hyyr	2837	29	the	the	DT
cord-006860-a3b8hyyr	2837	30	management	management	NN
cord-006860-a3b8hyyr	2837	31	of	of	IN
cord-006860-a3b8hyyr	2837	32	DVT	DVT	NNP
cord-006860-a3b8hyyr	2837	33	.	.	.
cord-006860-a3b8hyyr	2838	1	None	none	NN
cord-006860-a3b8hyyr	2838	2	of	of	IN
cord-006860-a3b8hyyr	2838	3	these	these	DT
cord-006860-a3b8hyyr	2838	4	patient	patient	JJ
cord-006860-a3b8hyyr	2838	5	groups	group	NNS
cord-006860-a3b8hyyr	2838	6	(	(	-LRB-
cord-006860-a3b8hyyr	2838	7	20	20	CD
cord-006860-a3b8hyyr	2838	8	-	-	SYM
cord-006860-a3b8hyyr	2838	9	34	34	CD
cord-006860-a3b8hyyr	2838	10	)	)	-RRB-
cord-006860-a3b8hyyr	2838	11	exhibited	exhibit	VBD
cord-006860-a3b8hyyr	2838	12	any	any	DT
cord-006860-a3b8hyyr	2838	13	HIT	HIT	VBN
cord-006860-a3b8hyyr	2838	14	responses	response	NNS
cord-006860-a3b8hyyr	2838	15	,	,	,
cord-006860-a3b8hyyr	2838	16	hmvever	hmvever	NNP
cord-006860-a3b8hyyr	2838	17	,	,	,
cord-006860-a3b8hyyr	2838	18	the	the	DT
cord-006860-a3b8hyyr	2838	19	incidence	incidence	NN
cord-006860-a3b8hyyr	2838	20	of	of	IN
cord-006860-a3b8hyyr	2838	21	high	high	JJ
cord-006860-a3b8hyyr	2838	22	HPF4-AB	HPF4-AB	NNP
cord-006860-a3b8hyyr	2838	23	titre	titre	NN
cord-006860-a3b8hyyr	2838	24	was	be	VBD
cord-006860-a3b8hyyr	2838	25	found	find	VBN
cord-006860-a3b8hyyr	2838	26	to	to	TO
cord-006860-a3b8hyyr	2838	27	be	be	VB
cord-006860-a3b8hyyr	2838	28	53	53	CD
cord-006860-a3b8hyyr	2838	29	%	%	NN
cord-006860-a3b8hyyr	2838	30	in	in	IN
cord-006860-a3b8hyyr	2838	31	heparin	heparin	NN
cord-006860-a3b8hyyr	2838	32	,	,	,
cord-006860-a3b8hyyr	2838	33	36	36	CD
cord-006860-a3b8hyyr	2838	34	%	%	NN
cord-006860-a3b8hyyr	2838	35	in	in	IN
cord-006860-a3b8hyyr	2838	36	patients	patient	NNS
cord-006860-a3b8hyyr	2838	37	with	with	IN
cord-006860-a3b8hyyr	2838	38	LMW	lmw	NN
cord-006860-a3b8hyyr	2838	39	heparin	heparin	NN
cord-006860-a3b8hyyr	2838	40	IV	IV	NNP
cord-006860-a3b8hyyr	2838	41	and	and	CC
cord-006860-a3b8hyyr	2838	42	26	26	CD
cord-006860-a3b8hyyr	2838	43	%	%	NN
cord-006860-a3b8hyyr	2838	44	in	in	IN
cord-006860-a3b8hyyr	2838	45	LMW	lmw	NN
cord-006860-a3b8hyyr	2838	46	heparin	heparin	JJ
cord-006860-a3b8hyyr	2838	47	SC	SC	NNP
cord-006860-a3b8hyyr	2838	48	groups	group	NNS
cord-006860-a3b8hyyr	2838	49	.	.	.
cord-006860-a3b8hyyr	2839	1	PA	PA	NNP
cord-006860-a3b8hyyr	2839	2	and	and	CC
cord-006860-a3b8hyyr	2839	3	SR	SR	NNP
cord-006860-a3b8hyyr	2839	4	studies	study	NNS
cord-006860-a3b8hyyr	2839	5	revealed	reveal	VBD
cord-006860-a3b8hyyr	2839	6	8	8	CD
cord-006860-a3b8hyyr	2839	7	%	%	NN
cord-006860-a3b8hyyr	2839	8	and	and	CC
cord-006860-a3b8hyyr	2839	9	12	12	CD
cord-006860-a3b8hyyr	2839	10	%	%	NN
cord-006860-a3b8hyyr	2839	11	false	false	JJ
cord-006860-a3b8hyyr	2839	12	positive	positive	JJ
cord-006860-a3b8hyyr	2839	13	~	~	NFP
cord-006860-a3b8hyyr	2839	14	respeetively	respeetively	NN
cord-006860-a3b8hyyr	2839	15	.	.	.
cord-006860-a3b8hyyr	2840	1	These	these	DT
cord-006860-a3b8hyyr	2840	2	studies	study	NNS
cord-006860-a3b8hyyr	2840	3	clearty	clearty	NNP
cord-006860-a3b8hyyr	2840	4	suggest	suggest	VBP
cord-006860-a3b8hyyr	2840	5	that	that	IN
cord-006860-a3b8hyyr	2840	6	the	the	DT
cord-006860-a3b8hyyr	2840	7	currently	currently	RB
cord-006860-a3b8hyyr	2840	8	available	available	JJ
cord-006860-a3b8hyyr	2840	9	~	~	NFP
cord-006860-a3b8hyyr	2840	10	for	for	IN
cord-006860-a3b8hyyr	2840	11	laboratory	laboratory	NN
cord-006860-a3b8hyyr	2840	12	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	2840	13	of	of	IN
cord-006860-a3b8hyyr	2840	14	HIT	HIT	NNP
cord-006860-a3b8hyyr	2840	15	syndrome	syndrome	NN
cord-006860-a3b8hyyr	2840	16	are	be	VBP
cord-006860-a3b8hyyr	2840	17	of	of	IN
cord-006860-a3b8hyyr	2840	18	limited	limited	JJ
cord-006860-a3b8hyyr	2840	19	value	value	NN
cord-006860-a3b8hyyr	2840	20	,	,	,
cord-006860-a3b8hyyr	2840	21	and	and	CC
cord-006860-a3b8hyyr	2840	22	caution	caution	NN
cord-006860-a3b8hyyr	2840	23	should	should	MD
cord-006860-a3b8hyyr	2840	24	be	be	VB
cord-006860-a3b8hyyr	2840	25	exercised	exercise	VBN
cord-006860-a3b8hyyr	2840	26	in	in	IN
cord-006860-a3b8hyyr	2840	27	the	the	DT
cord-006860-a3b8hyyr	2840	28	interpretation	interpretation	NN
cord-006860-a3b8hyyr	2840	29	of	of	IN
cord-006860-a3b8hyyr	2840	30	the	the	DT
cord-006860-a3b8hyyr	2840	31	results	result	NNS
cord-006860-a3b8hyyr	2840	32	obtained	obtain	VBN
cord-006860-a3b8hyyr	2840	33	with	with	IN
cord-006860-a3b8hyyr	2840	34	these	these	DT
cord-006860-a3b8hyyr	2840	35	tests	test	NNS
cord-006860-a3b8hyyr	2840	36	.	.	.
cord-006860-a3b8hyyr	2841	1	Heparin	heparin	NN
cord-006860-a3b8hyyr	2841	2	-	-	HYPH
cord-006860-a3b8hyyr	2841	3	induced	induce	VBN
cord-006860-a3b8hyyr	2841	4	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2841	5	(	(	-LRB-
cord-006860-a3b8hyyr	2841	6	HIT	hit	NN
cord-006860-a3b8hyyr	2841	7	)	)	-RRB-
cord-006860-a3b8hyyr	2841	8	is	be	VBZ
cord-006860-a3b8hyyr	2841	9	one	one	CD
cord-006860-a3b8hyyr	2841	10	of	of	IN
cord-006860-a3b8hyyr	2841	11	the	the	DT
cord-006860-a3b8hyyr	2841	12	major	major	JJ
cord-006860-a3b8hyyr	2841	13	severe	severe	JJ
cord-006860-a3b8hyyr	2841	14	side	side	NN
cord-006860-a3b8hyyr	2841	15	effects	effect	NNS
cord-006860-a3b8hyyr	2841	16	during	during	IN
cord-006860-a3b8hyyr	2841	17	treatment	treatment	NN
cord-006860-a3b8hyyr	2841	18	with	with	IN
cord-006860-a3b8hyyr	2841	19	heparin	heparin	NN
cord-006860-a3b8hyyr	2841	20	.	.	.
cord-006860-a3b8hyyr	2842	1	In	in	IN
cord-006860-a3b8hyyr	2842	2	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	2842	3	medicine	medicine	NN
cord-006860-a3b8hyyr	2842	4	clinical	clinical	JJ
cord-006860-a3b8hyyr	2842	5	studies	study	NNS
cord-006860-a3b8hyyr	2842	6	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	2842	7	the	the	DT
cord-006860-a3b8hyyr	2842	8	prevalence	prevalence	NN
cord-006860-a3b8hyyr	2842	9	of	of	IN
cord-006860-a3b8hyyr	2842	10	HIT	HIT	VBN
cord-006860-a3b8hyyr	2842	11	with	with	IN
cord-006860-a3b8hyyr	2842	12	unfractionated	unfractionated	JJ
cord-006860-a3b8hyyr	2842	13	over	over	IN
cord-006860-a3b8hyyr	2842	14	fractionated	fractionate	VBN
cord-006860-a3b8hyyr	2842	15	heparins	heparin	NNS
cord-006860-a3b8hyyr	2842	16	.	.	.
cord-006860-a3b8hyyr	2843	1	Few	few	JJ
cord-006860-a3b8hyyr	2843	2	data	datum	NNS
cord-006860-a3b8hyyr	2843	3	are	be	VBP
cord-006860-a3b8hyyr	2843	4	available	available	JJ
cord-006860-a3b8hyyr	2843	5	from	from	IN
cord-006860-a3b8hyyr	2843	6	the	the	DT
cord-006860-a3b8hyyr	2843	7	non	non	JJ
cord-006860-a3b8hyyr	2843	8	-	-	JJ
cord-006860-a3b8hyyr	2843	9	ope1"ative	ope1"ative	JJ
cord-006860-a3b8hyyr	2843	10	medicine	medicine	NN
cord-006860-a3b8hyyr	2843	11	and	and	CC
cord-006860-a3b8hyyr	2843	12	from	from	IN
cord-006860-a3b8hyyr	2843	13	patients	patient	NNS
cord-006860-a3b8hyyr	2843	14	without	without	IN
cord-006860-a3b8hyyr	2843	15	thmmboembolism	thmmboembolism	NN
cord-006860-a3b8hyyr	2843	16	before	before	IN
cord-006860-a3b8hyyr	2843	17	heparinization	heparinization	NN
cord-006860-a3b8hyyr	2843	18	.	.	.
cord-006860-a3b8hyyr	2844	1	In	in	IN
cord-006860-a3b8hyyr	2844	2	a	a	DT
cord-006860-a3b8hyyr	2844	3	controlled	control	VBN
cord-006860-a3b8hyyr	2844	4	prospective	prospective	JJ
cord-006860-a3b8hyyr	2844	5	randomized	randomized	JJ
cord-006860-a3b8hyyr	2844	6	study	study	NN
cord-006860-a3b8hyyr	2844	7	the	the	DT
cord-006860-a3b8hyyr	2844	8	safety	safety	NN
cord-006860-a3b8hyyr	2844	9	and	and	CC
cord-006860-a3b8hyyr	2844	10	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2844	11	of	of	IN
cord-006860-a3b8hyyr	2844	12	low	low	JJ
cord-006860-a3b8hyyr	2844	13	-	-	HYPH
cord-006860-a3b8hyyr	2844	14	dose	dose	NN
cord-006860-a3b8hyyr	2844	15	heparin	heparin	NN
cord-006860-a3b8hyyr	2844	16	was	be	VBD
cord-006860-a3b8hyyr	2844	17	compared	compare	VBN
cord-006860-a3b8hyyr	2844	18	with	with	IN
cord-006860-a3b8hyyr	2844	19	a	a	DT
cord-006860-a3b8hyyr	2844	20	lowmolecular	lowmolecular	JJ
cord-006860-a3b8hyyr	2844	21	-	-	HYPH
cord-006860-a3b8hyyr	2844	22	weight	weight	NN
cord-006860-a3b8hyyr	2844	23	(	(	-LRB-
cord-006860-a3b8hyyr	2844	24	LMW	lmw	NN
cord-006860-a3b8hyyr	2844	25	)	)	-RRB-
cord-006860-a3b8hyyr	2844	26	heparin	heparin	NN
cord-006860-a3b8hyyr	2844	27	over	over	IN
cord-006860-a3b8hyyr	2844	28	10	10	CD
cord-006860-a3b8hyyr	2844	29	days	day	NNS
cord-006860-a3b8hyyr	2844	30	in	in	IN
cord-006860-a3b8hyyr	2844	31	bedridden	bedridden	JJ
cord-006860-a3b8hyyr	2844	32	medical	medical	JJ
cord-006860-a3b8hyyr	2844	33	inpatients	inpatient	NNS
cord-006860-a3b8hyyr	2844	34	(	(	-LRB-
cord-006860-a3b8hyyr	2844	35	Haemostasis	Haemostasis	NNP
cord-006860-a3b8hyyr	2844	36	,	,	,
cord-006860-a3b8hyyr	2844	37	in	in	IN
cord-006860-a3b8hyyr	2844	38	press	press	NN
cord-006860-a3b8hyyr	2844	39	)	)	-RRB-
cord-006860-a3b8hyyr	2844	40	.	.	.
cord-006860-a3b8hyyr	2845	1	1968	1968	CD
cord-006860-a3b8hyyr	2845	2	patients	patient	NNS
cord-006860-a3b8hyyr	2845	3	were	be	VBD
cord-006860-a3b8hyyr	2845	4	randomized	randomize	VBN
cord-006860-a3b8hyyr	2845	5	and	and	CC
cord-006860-a3b8hyyr	2845	6	controlled	control	VBN
cord-006860-a3b8hyyr	2845	7	for	for	IN
cord-006860-a3b8hyyr	2845	8	the	the	DT
cord-006860-a3b8hyyr	2845	9	development	development	NN
cord-006860-a3b8hyyr	2845	10	of	of	IN
cord-006860-a3b8hyyr	2845	11	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2845	12	.	.	.
cord-006860-a3b8hyyr	2846	1	Thrombocytopenia	Thrombocytopenia	NNP
cord-006860-a3b8hyyr	2846	2	was	be	VBD
cord-006860-a3b8hyyr	2846	3	defined	define	VBN
cord-006860-a3b8hyyr	2846	4	as	as	IN
cord-006860-a3b8hyyr	2846	5	a	a	DT
cord-006860-a3b8hyyr	2846	6	platelet	platelet	NN
cord-006860-a3b8hyyr	2846	7	count	count	NN
cord-006860-a3b8hyyr	2846	8	below	below	IN
cord-006860-a3b8hyyr	2846	9	40.000lid	40.000lid	CD
cord-006860-a3b8hyyr	2846	10	at	at	IN
cord-006860-a3b8hyyr	2846	11	day	day	NN
cord-006860-a3b8hyyr	2846	12	10	10	CD
cord-006860-a3b8hyyr	2846	13	.	.	.
cord-006860-a3b8hyyr	2847	1	4	4	CD
cord-006860-a3b8hyyr	2847	2	patients	patient	NNS
cord-006860-a3b8hyyr	2847	3	developed	develop	VBN
cord-006860-a3b8hyyr	2847	4	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2847	5	in	in	IN
cord-006860-a3b8hyyr	2847	6	the	the	DT
cord-006860-a3b8hyyr	2847	7	heparin	heparin	NNP
cord-006860-a3b8hyyr	2847	8	group	group	NN
cord-006860-a3b8hyyr	2847	9	and	and	CC
cord-006860-a3b8hyyr	2847	10	no	no	DT
cord-006860-a3b8hyyr	2847	11	patient	patient	NN
cord-006860-a3b8hyyr	2847	12	in	in	IN
cord-006860-a3b8hyyr	2847	13	the	the	DT
cord-006860-a3b8hyyr	2847	14	LMWheparin	LMWheparin	NNP
cord-006860-a3b8hyyr	2847	15	group	group	NN
cord-006860-a3b8hyyr	2847	16	(	(	-LRB-
cord-006860-a3b8hyyr	2847	17	p<0.05	p<0.05	CD
cord-006860-a3b8hyyr	2847	18	)	)	-RRB-
cord-006860-a3b8hyyr	2847	19	.	.	.
cord-006860-a3b8hyyr	2848	1	None	none	NN
cord-006860-a3b8hyyr	2848	2	of	of	IN
cord-006860-a3b8hyyr	2848	3	the	the	DT
cord-006860-a3b8hyyr	2848	4	patients	patient	NNS
cord-006860-a3b8hyyr	2848	5	with	with	IN
cord-006860-a3b8hyyr	2848	6	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2848	7	developed	develop	VBD
cord-006860-a3b8hyyr	2848	8	a	a	DT
cord-006860-a3b8hyyr	2848	9	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	2848	10	complication	complication	NN
cord-006860-a3b8hyyr	2848	11	.	.	.
cord-006860-a3b8hyyr	2849	1	In	in	IN
cord-006860-a3b8hyyr	2849	2	a	a	DT
cord-006860-a3b8hyyr	2849	3	second	second	JJ
cord-006860-a3b8hyyr	2849	4	prospective	prospective	JJ
cord-006860-a3b8hyyr	2849	5	case	case	NN
cord-006860-a3b8hyyr	2849	6	control	control	NN
cord-006860-a3b8hyyr	2849	7	study	study	NN
cord-006860-a3b8hyyr	2849	8	90	90	CD
cord-006860-a3b8hyyr	2849	9	patients	patient	NNS
cord-006860-a3b8hyyr	2849	10	with	with	IN
cord-006860-a3b8hyyr	2849	11	side	side	JJ
cord-006860-a3b8hyyr	2849	12	effects	effect	NNS
cord-006860-a3b8hyyr	2849	13	on	on	IN
cord-006860-a3b8hyyr	2849	14	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	2849	15	were	be	VBD
cord-006860-a3b8hyyr	2849	16	treated	treat	VBN
cord-006860-a3b8hyyr	2849	17	with	with	IN
cord-006860-a3b8hyyr	2849	18	LMW	lmw	NN
cord-006860-a3b8hyyr	2849	19	-	-	HYPH
cord-006860-a3b8hyyr	2849	20	heparin	heparin	NN
cord-006860-a3b8hyyr	2849	21	once	once	IN
cord-006860-a3b8hyyr	2849	22	daily	daily	RB
cord-006860-a3b8hyyr	2849	23	subcutaneously	subcutaneously	RB
cord-006860-a3b8hyyr	2849	24	for	for	IN
cord-006860-a3b8hyyr	2849	25	a	a	DT
cord-006860-a3b8hyyr	2849	26	period	period	NN
cord-006860-a3b8hyyr	2849	27	of	of	IN
cord-006860-a3b8hyyr	2849	28	1	1	CD
cord-006860-a3b8hyyr	2849	29	month	month	NN
cord-006860-a3b8hyyr	2849	30	to	to	IN
cord-006860-a3b8hyyr	2849	31	9	9	CD
cord-006860-a3b8hyyr	2849	32	years	year	NNS
cord-006860-a3b8hyyr	2849	33	.	.	.
cord-006860-a3b8hyyr	2850	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	2850	2	count	count	NN
cord-006860-a3b8hyyr	2850	3	was	be	VBD
cord-006860-a3b8hyyr	2850	4	performed	perform	VBN
cord-006860-a3b8hyyr	2850	5	every	every	DT
cord-006860-a3b8hyyr	2850	6	1	1	CD
cord-006860-a3b8hyyr	2850	7	to	to	IN
cord-006860-a3b8hyyr	2850	8	3	3	CD
cord-006860-a3b8hyyr	2850	9	months	month	NNS
cord-006860-a3b8hyyr	2850	10	.	.	.
cord-006860-a3b8hyyr	2851	1	None	none	NN
cord-006860-a3b8hyyr	2851	2	of	of	IN
cord-006860-a3b8hyyr	2851	3	these	these	DT
cord-006860-a3b8hyyr	2851	4	patients	patient	NNS
cord-006860-a3b8hyyr	2851	5	developed	develop	VBD
cord-006860-a3b8hyyr	2851	6	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	2851	7	during	during	IN
cord-006860-a3b8hyyr	2851	8	heparinization	heparinization	NN
cord-006860-a3b8hyyr	2851	9	with	with	IN
cord-006860-a3b8hyyr	2851	10	LMW	lmw	NN
cord-006860-a3b8hyyr	2851	11	-	-	HYPH
cord-006860-a3b8hyyr	2851	12	heparin	heparin	JJ
cord-006860-a3b8hyyr	2851	13	.	.	.
cord-006860-a3b8hyyr	2852	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	2852	2	is	be	VBZ
cord-006860-a3b8hyyr	2852	3	concluded	conclude	VBN
cord-006860-a3b8hyyr	2852	4	that	that	IN
cord-006860-a3b8hyyr	2852	5	HIT	hit	NN
cord-006860-a3b8hyyr	2852	6	is	be	VBZ
cord-006860-a3b8hyyr	2852	7	a	a	DT
cord-006860-a3b8hyyr	2852	8	very	very	RB
cord-006860-a3b8hyyr	2852	9	rare	rare	JJ
cord-006860-a3b8hyyr	2852	10	complication	complication	NN
cord-006860-a3b8hyyr	2852	11	in	in	IN
cord-006860-a3b8hyyr	2852	12	nonoperated	nonoperated	JJ
cord-006860-a3b8hyyr	2852	13	bedridden	bedridden	JJ
cord-006860-a3b8hyyr	2852	14	medical	medical	JJ
cord-006860-a3b8hyyr	2852	15	patients	patient	NNS
cord-006860-a3b8hyyr	2852	16	.	.	.
cord-006860-a3b8hyyr	2853	1	A	a	DT
cord-006860-a3b8hyyr	2853	2	decrease	decrease	NN
cord-006860-a3b8hyyr	2853	3	of	of	IN
cord-006860-a3b8hyyr	2853	4	platetet	platetet	NNP
cord-006860-a3b8hyyr	2853	5	count	count	NNP
cord-006860-a3b8hyyr	2853	6	may	may	MD
cord-006860-a3b8hyyr	2853	7	occur	occur	VB
cord-006860-a3b8hyyr	2853	8	in	in	IN
cord-006860-a3b8hyyr	2853	9	about	about	RB
cord-006860-a3b8hyyr	2853	10	0.5	0.5	CD
cord-006860-a3b8hyyr	2853	11	%	%	NN
cord-006860-a3b8hyyr	2853	12	of	of	IN
cord-006860-a3b8hyyr	2853	13	patients	patient	NNS
cord-006860-a3b8hyyr	2853	14	receiving	receive	VBG
cord-006860-a3b8hyyr	2853	15	low	low	JJ
cord-006860-a3b8hyyr	2853	16	-	-	HYPH
cord-006860-a3b8hyyr	2853	17	dose	dose	NN
cord-006860-a3b8hyyr	2853	18	heparin	heparin	NN
cord-006860-a3b8hyyr	2853	19	.	.	.
cord-006860-a3b8hyyr	2854	1	The	the	DT
cord-006860-a3b8hyyr	2854	2	incidence	incidence	NN
cord-006860-a3b8hyyr	2854	3	of	of	IN
cord-006860-a3b8hyyr	2854	4	HIT	HIT	VBN
cord-006860-a3b8hyyr	2854	5	with	with	IN
cord-006860-a3b8hyyr	2854	6	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	2854	7	during	during	IN
cord-006860-a3b8hyyr	2854	8	low	low	JJ
cord-006860-a3b8hyyr	2854	9	-	-	HYPH
cord-006860-a3b8hyyr	2854	10	dose	dose	NN
cord-006860-a3b8hyyr	2854	11	heparin	heparin	NN
cord-006860-a3b8hyyr	2854	12	and	and	CC
cord-006860-a3b8hyyr	2854	13	of	of	IN
cord-006860-a3b8hyyr	2854	14	HIT	HIT	NNP
cord-006860-a3b8hyyr	2854	15	during	during	IN
cord-006860-a3b8hyyr	2854	16	LMW	lmw	NN
cord-006860-a3b8hyyr	2854	17	-	-	HYPH
cord-006860-a3b8hyyr	2854	18	heparin	heparin	JJ
cord-006860-a3b8hyyr	2854	19	in	in	IN
cord-006860-a3b8hyyr	2854	20	non	non	JJ
cord-006860-a3b8hyyr	2854	21	-	-	JJ
cord-006860-a3b8hyyr	2854	22	operated	operate	VBN
cord-006860-a3b8hyyr	2854	23	patients	patient	NNS
cord-006860-a3b8hyyr	2854	24	is	be	VBZ
cord-006860-a3b8hyyr	2854	25	manyfold	manyfold	JJ
cord-006860-a3b8hyyr	2854	26	lower	low	JJR
cord-006860-a3b8hyyr	2854	27	and	and	CC
cord-006860-a3b8hyyr	2854	28	remains	remain	VBZ
cord-006860-a3b8hyyr	2854	29	to	to	TO
cord-006860-a3b8hyyr	2854	30	be	be	VB
cord-006860-a3b8hyyr	2854	31	determined	determine	VBN
cord-006860-a3b8hyyr	2854	32	.	.	.
cord-006860-a3b8hyyr	2855	1	Terminology	terminology	NN
cord-006860-a3b8hyyr	2855	2	:	:	:
cord-006860-a3b8hyyr	2856	1	Instead	instead	RB
cord-006860-a3b8hyyr	2856	2	of	of	IN
cord-006860-a3b8hyyr	2856	3	the	the	DT
cord-006860-a3b8hyyr	2856	4	term	term	NN
cord-006860-a3b8hyyr	2856	5	"	"	``
cord-006860-a3b8hyyr	2856	6	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	2856	7	disease	disease	NN
cord-006860-a3b8hyyr	2856	8	of	of	IN
cord-006860-a3b8hyyr	2856	9	the	the	DT
cord-006860-a3b8hyyr	2856	10	newborn	newborn	NN
cord-006860-a3b8hyyr	2856	11	(	(	-LRB-
cord-006860-a3b8hyyr	2856	12	HDN	HDN	NNP
cord-006860-a3b8hyyr	2856	13	)	)	-RRB-
cord-006860-a3b8hyyr	2856	14	"	"	``
cord-006860-a3b8hyyr	2856	15	the	the	DT
cord-006860-a3b8hyyr	2856	16	term	term	NN
cord-006860-a3b8hyyr	2856	17	VKDB	VKDB	NNP
cord-006860-a3b8hyyr	2856	18	should	should	MD
cord-006860-a3b8hyyr	2856	19	be	be	VB
cord-006860-a3b8hyyr	2856	20	used	use	VBN
cord-006860-a3b8hyyr	2856	21	,	,	,
cord-006860-a3b8hyyr	2856	22	since	since	IN
cord-006860-a3b8hyyr	2856	23	neonatal	neonatal	JJ
cord-006860-a3b8hyyr	2856	24	bleeding	bleeding	NN
cord-006860-a3b8hyyr	2856	25	is	be	VBZ
cord-006860-a3b8hyyr	2856	26	often	often	RB
cord-006860-a3b8hyyr	2856	27	not	not	RB
cord-006860-a3b8hyyr	2856	28	due	due	JJ
cord-006860-a3b8hyyr	2856	29	to	to	IN
cord-006860-a3b8hyyr	2856	30	VKdeficieacy	vkdeficieacy	NN
cord-006860-a3b8hyyr	2856	31	and	and	CC
cord-006860-a3b8hyyr	2856	32	VKDB	VKDB	NNP
cord-006860-a3b8hyyr	2856	33	may	may	MD
cord-006860-a3b8hyyr	2856	34	occur	occur	VB
cord-006860-a3b8hyyr	2856	35	after	after	IN
cord-006860-a3b8hyyr	2856	36	the	the	DT
cord-006860-a3b8hyyr	2856	37	neonatal	neonatal	JJ
cord-006860-a3b8hyyr	2856	38	period	period	NN
cord-006860-a3b8hyyr	2856	39	(	(	-LRB-
cord-006860-a3b8hyyr	2856	40	i.e.	i.e.	FW
cord-006860-a3b8hyyr	2856	41	after	after	IN
cord-006860-a3b8hyyr	2856	42	4	4	CD
cord-006860-a3b8hyyr	2856	43	weeks	week	NNS
cord-006860-a3b8hyyr	2856	44	)	)	-RRB-
cord-006860-a3b8hyyr	2856	45	.	.	.
cord-006860-a3b8hyyr	2857	1	Definition	definition	NN
cord-006860-a3b8hyyr	2857	2	:	:	:
cord-006860-a3b8hyyr	2858	1	VKDB	VKDB	NNP
cord-006860-a3b8hyyr	2858	2	is	be	VBZ
cord-006860-a3b8hyyr	2858	3	a	a	DT
cord-006860-a3b8hyyr	2858	4	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2858	5	disorder	disorder	NN
cord-006860-a3b8hyyr	2858	6	caused	cause	VBN
cord-006860-a3b8hyyr	2858	7	by	by	IN
cord-006860-a3b8hyyr	2858	8	reduced	reduced	JJ
cord-006860-a3b8hyyr	2858	9	activity	activity	NN
cord-006860-a3b8hyyr	2858	10	of	of	IN
cord-006860-a3b8hyyr	2858	11	VKdependent	VKdependent	NNP
cord-006860-a3b8hyyr	2858	12	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2858	13	factors	factor	NNS
cord-006860-a3b8hyyr	2858	14	which	which	WDT
cord-006860-a3b8hyyr	2858	15	responds	respond	VBZ
cord-006860-a3b8hyyr	2858	16	to	to	IN
cord-006860-a3b8hyyr	2858	17	VK	VK	NNP
cord-006860-a3b8hyyr	2858	18	.	.	.
cord-006860-a3b8hyyr	2859	1	Diagnnsis	diagnnsis	NN
cord-006860-a3b8hyyr	2859	2	:	:	:
cord-006860-a3b8hyyr	2860	1	in	in	IN
cord-006860-a3b8hyyr	2860	2	a	a	DT
cord-006860-a3b8hyyr	2860	3	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2860	4	infant	infant	NN
cord-006860-a3b8hyyr	2860	5	a	a	DT
cord-006860-a3b8hyyr	2860	6	prolonged	prolong	VBN
cord-006860-a3b8hyyr	2860	7	PT	pt	NN
cord-006860-a3b8hyyr	2860	8	(	(	-LRB-
cord-006860-a3b8hyyr	2860	9	INR	INR	NNP
cord-006860-a3b8hyyr	2860	10	>	>	XX
cord-006860-a3b8hyyr	2860	11	3.5	3.5	CD
cord-006860-a3b8hyyr	2860	12	)	)	-RRB-
cord-006860-a3b8hyyr	2860	13	together	together	RB
cord-006860-a3b8hyyr	2860	14	with	with	IN
cord-006860-a3b8hyyr	2860	15	normal	normal	JJ
cord-006860-a3b8hyyr	2860	16	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	2860	17	and	and	CC
cord-006860-a3b8hyyr	2860	18	platelet	platelet	NN
cord-006860-a3b8hyyr	2860	19	count	count	NN
cord-006860-a3b8hyyr	2860	20	is	be	VBZ
cord-006860-a3b8hyyr	2860	21	almost	almost	RB
cord-006860-a3b8hyyr	2860	22	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	2860	23	of	of	IN
cord-006860-a3b8hyyr	2860	24	VKDB	VKDB	NNP
cord-006860-a3b8hyyr	2860	25	.	.	.
cord-006860-a3b8hyyr	2861	1	The	the	DT
cord-006860-a3b8hyyr	2861	2	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	2861	3	is	be	VBZ
cord-006860-a3b8hyyr	2861	4	proven	prove	VBN
cord-006860-a3b8hyyr	2861	5	,	,	,
cord-006860-a3b8hyyr	2861	6	if	if	IN
cord-006860-a3b8hyyr	2861	7	VK	VK	NNP
cord-006860-a3b8hyyr	2861	8	shortens	shorten	VBZ
cord-006860-a3b8hyyr	2861	9	the	the	DT
cord-006860-a3b8hyyr	2861	10	PT	pt	NN
cord-006860-a3b8hyyr	2861	11	(	(	-LRB-
cord-006860-a3b8hyyr	2861	12	after	after	IN
cord-006860-a3b8hyyr	2861	13	only	only	RB
cord-006860-a3b8hyyr	2861	14	30	30	CD
cord-006860-a3b8hyyr	2861	15	-	-	SYM
cord-006860-a3b8hyyr	2861	16	60	60	CD
cord-006860-a3b8hyyr	2861	17	minutes	minute	NNS
cord-006860-a3b8hyyr	2861	18	)	)	-RRB-
cord-006860-a3b8hyyr	2861	19	and/or	and/or	CC
cord-006860-a3b8hyyr	2861	20	stops	stop	VBZ
cord-006860-a3b8hyyr	2861	21	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2861	22	.	.	.
cord-006860-a3b8hyyr	2862	1	Classification	classification	NN
cord-006860-a3b8hyyr	2862	2	:	:	:
cord-006860-a3b8hyyr	2862	3	Classification	classification	NN
cord-006860-a3b8hyyr	2862	4	by	by	IN
cord-006860-a3b8hyyr	2862	5	age	age	NN
cord-006860-a3b8hyyr	2862	6	of	of	IN
cord-006860-a3b8hyyr	2862	7	onset	onset	NN
cord-006860-a3b8hyyr	2862	8	into	into	IN
cord-006860-a3b8hyyr	2862	9	early	early	JJ
cord-006860-a3b8hyyr	2862	10	(	(	-LRB-
cord-006860-a3b8hyyr	2863	1	<	<	XX
cord-006860-a3b8hyyr	2863	2	24	24	CD
cord-006860-a3b8hyyr	2863	3	h~.	h~.	CD
cord-006860-a3b8hyyr	2863	4	classic	classic	JJ
cord-006860-a3b8hyyr	2863	5	fdav	fdav	JJ
cord-006860-a3b8hyyr	2863	6	2	2	CD
cord-006860-a3b8hyyr	2863	7	-	-	SYM
cord-006860-a3b8hyyr	2863	8	7	7	CD
cord-006860-a3b8hyyr	2863	9	)	)	-RRB-
cord-006860-a3b8hyyr	2863	10	and	and	CC
cord-006860-a3b8hyyr	2863	11	lale	lale	NNP
cord-006860-a3b8hyyr	2863	12	form	form	NN
cord-006860-a3b8hyyr	2863	13	(	(	-LRB-
cord-006860-a3b8hyyr	2863	14	>	>	XX
cord-006860-a3b8hyyr	2863	15	I	-PRON-	PRP
cord-006860-a3b8hyyr	2863	16	week	week	VBP
cord-006860-a3b8hyyr	2863	17	<	<	XX
cord-006860-a3b8hyyr	2863	18	6	6	CD
cord-006860-a3b8hyyr	2863	19	months	month	NNS
cord-006860-a3b8hyyr	2863	20	)	)	-RRB-
cord-006860-a3b8hyyr	2863	21	,	,	.
cord-006860-a3b8hyyr	2864	1	and	and	CC
cord-006860-a3b8hyyr	2864	2	by	by	IN
cord-006860-a3b8hyyr	2864	3	etiology	etiology	NN
cord-006860-a3b8hyyr	2864	4	into	into	IN
cord-006860-a3b8hyyr	2864	5	idionathic	idionathic	JJ
cord-006860-a3b8hyyr	2864	6	and	and	CC
cord-006860-a3b8hyyr	2864	7	~ec0nd~'y	~ec0nd~'y	NFP
cord-006860-a3b8hyyr	2864	8	.	.	.
cord-006860-a3b8hyyr	2865	1	in	in	IN
cord-006860-a3b8hyyr	2865	2	secondary	secondary	JJ
cord-006860-a3b8hyyr	2865	3	VKDB	vkdb	NN
cord-006860-a3b8hyyr	2865	4	in	in	IN
cord-006860-a3b8hyyr	2865	5	addition	addition	NN
cord-006860-a3b8hyyr	2865	6	to	to	IN
cord-006860-a3b8hyyr	2865	7	breast	breast	NN
cord-006860-a3b8hyyr	2865	8	feeding	feeding	NN
cord-006860-a3b8hyyr	2865	9	other	other	JJ
cord-006860-a3b8hyyr	2865	10	factors	factor	NNS
cord-006860-a3b8hyyr	2865	11	can	can	MD
cord-006860-a3b8hyyr	2865	12	be	be	VB
cord-006860-a3b8hyyr	2865	13	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	2865	14	,	,	,
cord-006860-a3b8hyyr	2865	15	such	such	JJ
cord-006860-a3b8hyyr	2865	16	as	as	IN
cord-006860-a3b8hyyr	2865	17	poor	poor	JJ
cord-006860-a3b8hyyr	2865	18	intake	intake	NN
cord-006860-a3b8hyyr	2865	19	or	or	CC
cord-006860-a3b8hyyr	2865	20	absorption	absorption	NN
cord-006860-a3b8hyyr	2865	21	of	of	IN
cord-006860-a3b8hyyr	2865	22	VK	VK	NNP
cord-006860-a3b8hyyr	2865	23	and	and	CC
cord-006860-a3b8hyyr	2865	24	increased	increase	VBN
cord-006860-a3b8hyyr	2865	25	consumption	consumption	NN
cord-006860-a3b8hyyr	2865	26	of	of	IN
cord-006860-a3b8hyyr	2865	27	VK	VK	NNP
cord-006860-a3b8hyyr	2865	28	.	.	.
cord-006860-a3b8hyyr	2866	1	VK	VK	NNP
cord-006860-a3b8hyyr	2866	2	-	-	HYPH
cord-006860-a3b8hyyr	2866	3	Prophylaxis	Prophylaxis	NNP
cord-006860-a3b8hyyr	2866	4	:	:	:
cord-006860-a3b8hyyr	2866	5	Benefits	benefit	NNS
cord-006860-a3b8hyyr	2866	6	:	:	:
cord-006860-a3b8hyyr	2867	1	Oral	oral	JJ
cord-006860-a3b8hyyr	2867	2	and	and	CC
cord-006860-a3b8hyyr	2867	3	intramuscular	intramuscular	JJ
cord-006860-a3b8hyyr	2867	4	(	(	-LRB-
cord-006860-a3b8hyyr	2867	5	i.m	i.m	NNP
cord-006860-a3b8hyyr	2867	6	)	)	-RRB-
cord-006860-a3b8hyyr	2867	7	VK	VK	NNP
cord-006860-a3b8hyyr	2867	8	(	(	-LRB-
cord-006860-a3b8hyyr	2867	9	one	one	CD
cord-006860-a3b8hyyr	2867	10	dose	dose	NN
cord-006860-a3b8hyyr	2867	11	of	of	IN
cord-006860-a3b8hyyr	2867	12	I	-PRON-	PRP
cord-006860-a3b8hyyr	2867	13	nag	nag	VBP
cord-006860-a3b8hyyr	2867	14	)	)	-RRB-
cord-006860-a3b8hyyr	2867	15	prevents	prevent	VBZ
cord-006860-a3b8hyyr	2867	16	equally	equally	RB
cord-006860-a3b8hyyr	2867	17	well	well	RB
cord-006860-a3b8hyyr	2867	18	the	the	DT
cord-006860-a3b8hyyr	2867	19	classic	classic	JJ
cord-006860-a3b8hyyr	2867	20	form	form	NN
cord-006860-a3b8hyyr	2867	21	of	of	IN
cord-006860-a3b8hyyr	2867	22	VKDB	VKDB	NNP
cord-006860-a3b8hyyr	2867	23	.	.	.
cord-006860-a3b8hyyr	2868	1	Lm	Lm	NNP
cord-006860-a3b8hyyr	2868	2	.	.	.
cord-006860-a3b8hyyr	2869	1	VK	VK	NNP
cord-006860-a3b8hyyr	2869	2	appears	appear	VBZ
cord-006860-a3b8hyyr	2869	3	to	to	TO
cord-006860-a3b8hyyr	2869	4	be	be	VB
cord-006860-a3b8hyyr	2869	5	more	more	RBR
cord-006860-a3b8hyyr	2869	6	effective	effective	JJ
cord-006860-a3b8hyyr	2869	7	in	in	IN
cord-006860-a3b8hyyr	2869	8	preventing	prevent	VBG
cord-006860-a3b8hyyr	2869	9	the	the	DT
cord-006860-a3b8hyyr	2869	10	late	late	JJ
cord-006860-a3b8hyyr	2869	11	form	form	NN
cord-006860-a3b8hyyr	2869	12	(	(	-LRB-
cord-006860-a3b8hyyr	2869	13	times	time	NNS
cord-006860-a3b8hyyr	2870	1	15-	15-	LS
cord-006860-a3b8hyyr	2870	2	>	>	XX
cord-006860-a3b8hyyr	2870	3	50	50	CD
cord-006860-a3b8hyyr	2870	4	)	)	-RRB-
cord-006860-a3b8hyyr	2870	5	.	.	.
cord-006860-a3b8hyyr	2871	1	The	the	DT
cord-006860-a3b8hyyr	2871	2	protection	protection	NN
cord-006860-a3b8hyyr	2871	3	achieved	achieve	VBN
cord-006860-a3b8hyyr	2871	4	by	by	IN
cord-006860-a3b8hyyr	2871	5	single	single	JJ
cord-006860-a3b8hyyr	2871	6	oral	oral	JJ
cord-006860-a3b8hyyr	2871	7	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2871	8	(	(	-LRB-
cord-006860-a3b8hyyr	2871	9	times	time	NNS
cord-006860-a3b8hyyr	2871	10	3	3	CD
cord-006860-a3b8hyyr	2871	11	-	-	SYM
cord-006860-a3b8hyyr	2871	12	5	5	CD
cord-006860-a3b8hyyr	2871	13	)	)	-RRB-
cord-006860-a3b8hyyr	2871	14	is	be	VBZ
cord-006860-a3b8hyyr	2871	15	improved	improve	VBN
cord-006860-a3b8hyyr	2871	16	by	by	IN
cord-006860-a3b8hyyr	2871	17	triple	triple	JJ
cord-006860-a3b8hyyr	2871	18	oral	oral	JJ
cord-006860-a3b8hyyr	2871	19	VK	VK	NNP
cord-006860-a3b8hyyr	2871	20	(	(	-LRB-
cord-006860-a3b8hyyr	2871	21	times	time	NNS
cord-006860-a3b8hyyr	2871	22	15	15	CD
cord-006860-a3b8hyyr	2871	23	-	-	SYM
cord-006860-a3b8hyyr	2871	24	30	30	CD
cord-006860-a3b8hyyr	2871	25	)	)	-RRB-
cord-006860-a3b8hyyr	2871	26	.	.	.
cord-006860-a3b8hyyr	2872	1	Risks	risk	NNS
cord-006860-a3b8hyyr	2872	2	:	:	:
cord-006860-a3b8hyyr	2872	3	Because	because	IN
cord-006860-a3b8hyyr	2872	4	of	of	IN
cord-006860-a3b8hyyr	2872	5	poten[ial	poten[ial	JJ
cord-006860-a3b8hyyr	2872	6	ri	ri	NNP
cord-006860-a3b8hyyr	2872	7	~	~	NNP
cord-006860-a3b8hyyr	2872	8	l~	l~	XX
cord-006860-a3b8hyyr	2872	9	associated	associate	VBN
cord-006860-a3b8hyyr	2872	10	with	with	IN
cord-006860-a3b8hyyr	2872	11	extremely	extremely	RB
cord-006860-a3b8hyyr	2872	12	high	high	JJ
cord-006860-a3b8hyyr	2872	13	levels	level	NNS
cord-006860-a3b8hyyr	2872	14	of	of	IN
cord-006860-a3b8hyyr	2872	15	VK	VK	NNP
cord-006860-a3b8hyyr	2872	16	and	and	CC
cord-006860-a3b8hyyr	2872	17	the	the	DT
cord-006860-a3b8hyyr	2872	18	possibility	possibility	NN
cord-006860-a3b8hyyr	2872	19	of	of	IN
cord-006860-a3b8hyyr	2872	20	injection	injection	NN
cord-006860-a3b8hyyr	2872	21	injury	injury	NN
cord-006860-a3b8hyyr	2872	22	,	,	,
cord-006860-a3b8hyyr	2872	23	i.m	i.m	NNP
cord-006860-a3b8hyyr	2872	24	.	.	.
cord-006860-a3b8hyyr	2873	1	VK	VK	NNP
cord-006860-a3b8hyyr	2873	2	has	have	VBZ
cord-006860-a3b8hyyr	2873	3	been	be	VBN
cord-006860-a3b8hyyr	2873	4	questioned	question	VBN
cord-006860-a3b8hyyr	2873	5	as	as	IN
cord-006860-a3b8hyyr	2873	6	the	the	DT
cord-006860-a3b8hyyr	2873	7	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2873	8	of	of	IN
cord-006860-a3b8hyyr	2873	9	choice	choice	NN
cord-006860-a3b8hyyr	2873	10	for	for	IN
cord-006860-a3b8hyyr	2873	11	normal	normal	JJ
cord-006860-a3b8hyyr	2873	12	neonates	neonate	NNS
cord-006860-a3b8hyyr	2873	13	.	.	.
cord-006860-a3b8hyyr	2874	1	Since	since	IN
cord-006860-a3b8hyyr	2874	2	VK	VK	NNP
cord-006860-a3b8hyyr	2874	3	is	be	VBZ
cord-006860-a3b8hyyr	2874	4	involved	involve	VBN
cord-006860-a3b8hyyr	2874	5	not	not	RB
cord-006860-a3b8hyyr	2874	6	only	only	RB
cord-006860-a3b8hyyr	2874	7	in	in	IN
cord-006860-a3b8hyyr	2874	8	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2874	9	but	but	CC
cord-006860-a3b8hyyr	2874	10	'	'	''
cord-006860-a3b8hyyr	2874	11	also	also	RB
cord-006860-a3b8hyyr	2874	12	in	in	IN
cord-006860-a3b8hyyr	2874	13	carboxviation	carboxviation	NN
cord-006860-a3b8hyyr	2874	14	with	with	IN
cord-006860-a3b8hyyr	2874	15	multiple	multiple	JJ
cord-006860-a3b8hyyr	2874	16	effects	effect	NNS
cord-006860-a3b8hyyr	2874	17	,	,	,
cord-006860-a3b8hyyr	2874	18	excessive	excessive	JJ
cord-006860-a3b8hyyr	2874	19	deviations	deviation	NNS
cord-006860-a3b8hyyr	2874	20	from	from	IN
cord-006860-a3b8hyyr	2874	21	the	the	DT
cord-006860-a3b8hyyr	2874	22	low	low	JJ
cord-006860-a3b8hyyr	2874	23	physiologic	physiologic	JJ
cord-006860-a3b8hyyr	2874	24	concentrations	concentration	NNS
cord-006860-a3b8hyyr	2874	25	,	,	,
cord-006860-a3b8hyyr	2874	26	which	which	WDT
cord-006860-a3b8hyyr	2874	27	prevail	prevail	VBP
cord-006860-a3b8hyyr	2874	28	in	in	IN
cord-006860-a3b8hyyr	2874	29	the	the	DT
cord-006860-a3b8hyyr	2874	30	fully	fully	RB
cord-006860-a3b8hyyr	2874	31	breast	breast	NN
cord-006860-a3b8hyyr	2874	32	-	-	HYPH
cord-006860-a3b8hyyr	2874	33	fed	feed	VBN
cord-006860-a3b8hyyr	2874	34	healthy	healthy	JJ
cord-006860-a3b8hyyr	2874	35	mature	mature	JJ
cord-006860-a3b8hyyr	2874	36	infant	infant	NN
cord-006860-a3b8hyyr	2874	37	should	should	MD
cord-006860-a3b8hyyr	2874	38	be	be	VB
cord-006860-a3b8hyyr	2874	39	avoided	avoid	VBN
cord-006860-a3b8hyyr	2874	40	.	.	.
cord-006860-a3b8hyyr	2875	1	Proposal	proposal	NN
cord-006860-a3b8hyyr	2875	2	:	:	:
cord-006860-a3b8hyyr	2875	3	Repeated	repeat	VBN
cord-006860-a3b8hyyr	2875	4	(	(	-LRB-
cord-006860-a3b8hyyr	2875	5	daily	daily	JJ
cord-006860-a3b8hyyr	2875	6	or	or	CC
cord-006860-a3b8hyyr	2875	7	weekly	weekly	NN
cord-006860-a3b8hyyr	2875	8	)	)	-RRB-
cord-006860-a3b8hyyr	2876	1	small	small	JJ
cord-006860-a3b8hyyr	2876	2	oral	oral	JJ
cord-006860-a3b8hyyr	2876	3	doses	dose	NNS
cord-006860-a3b8hyyr	2876	4	of	of	IN
cord-006860-a3b8hyyr	2876	5	VK	VK	NNP
cord-006860-a3b8hyyr	2876	6	are	be	VBP
cord-006860-a3b8hyyr	2876	7	closer	close	JJR
cord-006860-a3b8hyyr	2876	8	to	to	IN
cord-006860-a3b8hyyr	2876	9	physiologic	physiologic	JJ
cord-006860-a3b8hyyr	2876	10	conditions	condition	NNS
cord-006860-a3b8hyyr	2876	11	than	than	IN
cord-006860-a3b8hyyr	2876	12	single	single	JJ
cord-006860-a3b8hyyr	2876	13	i.m	i.m	NNP
cord-006860-a3b8hyyr	2876	14	.	.	NNP
cord-006860-a3b8hyyr	2876	15	bolus	bolus	NNP
cord-006860-a3b8hyyr	2876	16	doses	dose	NNS
cord-006860-a3b8hyyr	2876	17	,	,	,
cord-006860-a3b8hyyr	2876	18	which	which	WDT
cord-006860-a3b8hyyr	2876	19	expose	expose	VBP
cord-006860-a3b8hyyr	2876	20	neonates	neonate	NNS
cord-006860-a3b8hyyr	2876	21	to	to	IN
cord-006860-a3b8hyyr	2876	22	excessively	excessively	RB
cord-006860-a3b8hyyr	2876	23	high	high	JJ
cord-006860-a3b8hyyr	2876	24	VK	VK	NNP
cord-006860-a3b8hyyr	2876	25	levels	level	NNS
cord-006860-a3b8hyyr	2876	26	.	.	.
cord-006860-a3b8hyyr	2877	1	The	the	DT
cord-006860-a3b8hyyr	2877	2	incidence	incidence	NN
cord-006860-a3b8hyyr	2877	3	of	of	IN
cord-006860-a3b8hyyr	2877	4	intracranial	intracranial	JJ
cord-006860-a3b8hyyr	2877	5	VKDB	VKDB	NNP
cord-006860-a3b8hyyr	2877	6	can	can	MD
cord-006860-a3b8hyyr	2877	7	be	be	VB
cord-006860-a3b8hyyr	2877	8	reduced	reduce	VBN
cord-006860-a3b8hyyr	2877	9	if	if	IN
cord-006860-a3b8hyyr	2877	10	the	the	DT
cord-006860-a3b8hyyr	2877	11	grave	grave	JJ
cord-006860-a3b8hyyr	2877	12	significance	significance	NN
cord-006860-a3b8hyyr	2877	13	of	of	IN
cord-006860-a3b8hyyr	2877	14	warning	warning	NN
cord-006860-a3b8hyyr	2877	15	signs	sign	NNS
cord-006860-a3b8hyyr	2877	16	is	be	VBZ
cord-006860-a3b8hyyr	2877	17	recognized	recognize	VBN
cord-006860-a3b8hyyr	2877	18	(	(	-LRB-
cord-006860-a3b8hyyr	2877	19	i.e	i.e	XX
cord-006860-a3b8hyyr	2877	20	,	,	,
cord-006860-a3b8hyyr	2877	21	icterns	ictern	NNS
cord-006860-a3b8hyyr	2877	22	,	,	,
cord-006860-a3b8hyyr	2877	23	failure	failure	NN
cord-006860-a3b8hyyr	2877	24	to	to	TO
cord-006860-a3b8hyyr	2877	25	thrive	thrive	VB
cord-006860-a3b8hyyr	2877	26	,	,	,
cord-006860-a3b8hyyr	2877	27	feeding	feeding	NN
cord-006860-a3b8hyyr	2877	28	problems	problem	NNS
cord-006860-a3b8hyyr	2877	29	,	,	,
cord-006860-a3b8hyyr	2877	30	minor	minor	JJ
cord-006860-a3b8hyyr	2877	31	bleeding	bleeding	NN
cord-006860-a3b8hyyr	2877	32	,	,	,
cord-006860-a3b8hyyr	2877	33	disease	disease	NN
cord-006860-a3b8hyyr	2877	34	with	with	IN
cord-006860-a3b8hyyr	2877	35	cholostasis	cholostasis	NN
cord-006860-a3b8hyyr	2877	36	)	)	-RRB-
cord-006860-a3b8hyyr	2877	37	.	.	.
cord-006860-a3b8hyyr	2878	1	Whether	whether	IN
cord-006860-a3b8hyyr	2878	2	or	or	CC
cord-006860-a3b8hyyr	2878	3	not	not	RB
cord-006860-a3b8hyyr	2878	4	the	the	DT
cord-006860-a3b8hyyr	2878	5	more	more	RBR
cord-006860-a3b8hyyr	2878	6	reliable	reliable	JJ
cord-006860-a3b8hyyr	2878	7	absorption	absorption	NN
cord-006860-a3b8hyyr	2878	8	of	of	IN
cord-006860-a3b8hyyr	2878	9	the	the	DT
cord-006860-a3b8hyyr	2878	10	new	new	JJ
cord-006860-a3b8hyyr	2878	11	mixed	mixed	JJ
cord-006860-a3b8hyyr	2878	12	mieellar	mieellar	NNP
cord-006860-a3b8hyyr	2878	13	(	(	-LRB-
cord-006860-a3b8hyyr	2878	14	MM~	MM~	NNP
cord-006860-a3b8hyyr	2878	15	nrenaral~	nrenaral~	ADD
cord-006860-a3b8hyyr	2879	1	i0n	i0n	VBN
cord-006860-a3b8hyyr	2879	2	of	of	IN
cord-006860-a3b8hyyr	2879	3	VK	VK	NNP
cord-006860-a3b8hyyr	2879	4	can	can	MD
cord-006860-a3b8hyyr	2879	5	reduce	reduce	VB
cord-006860-a3b8hyyr	2879	6	the	the	DT
cord-006860-a3b8hyyr	2879	7	protective	protective	JJ
cord-006860-a3b8hyyr	2879	8	oral	oral	JJ
cord-006860-a3b8hyyr	2879	9	dose	dose	NN
cord-006860-a3b8hyyr	2879	10	of	of	IN
cord-006860-a3b8hyyr	2879	11	VK-.prophylaxis	VK-.prophylaxis	NNP
cord-006860-a3b8hyyr	2880	1	has	have	VBZ
cord-006860-a3b8hyyr	2880	2	to	to	TO
cord-006860-a3b8hyyr	2880	3	be	be	VB
cord-006860-a3b8hyyr	2880	4	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	2880	5	.	.	.
cord-006860-a3b8hyyr	2881	1	Before	before	IN
cord-006860-a3b8hyyr	2881	2	Vitamin	vitamin	NN
cord-006860-a3b8hyyr	2881	3	K(VK	K(VK	NNP
cord-006860-a3b8hyyr	2881	4	)	)	-RRB-
cord-006860-a3b8hyyr	2881	5	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	2881	6	was	be	VBD
cord-006860-a3b8hyyr	2881	7	generally	generally	RB
cord-006860-a3b8hyyr	2881	8	accepted	accept	VBN
cord-006860-a3b8hyyr	2881	9	in	in	IN
cord-006860-a3b8hyyr	2881	10	Japan	Japan	NNP
cord-006860-a3b8hyyr	2881	11	,	,	,
cord-006860-a3b8hyyr	2881	12	the	the	DT
cord-006860-a3b8hyyr	2881	13	incidence	incidence	NN
cord-006860-a3b8hyyr	2881	14	of	of	IN
cord-006860-a3b8hyyr	2881	15	infantile	infantile	JJ
cord-006860-a3b8hyyr	2881	16	VK	VK	NNP
cord-006860-a3b8hyyr	2881	17	deficiency	deficiency	NN
cord-006860-a3b8hyyr	2881	18	was	be	VBD
cord-006860-a3b8hyyr	2881	19	1:4000	1:4000	CD
cord-006860-a3b8hyyr	2882	1	both	both	DT
cord-006860-a3b8hyyr	2882	2	idiopathic	idiopathic	JJ
cord-006860-a3b8hyyr	2882	3	and	and	CC
cord-006860-a3b8hyyr	2882	4	secondary	secondary	JJ
cord-006860-a3b8hyyr	2882	5	types	type	NNS
cord-006860-a3b8hyyr	2882	6	.	.	.
cord-006860-a3b8hyyr	2883	1	Since	since	IN
cord-006860-a3b8hyyr	2883	2	1981	1981	CD
cord-006860-a3b8hyyr	2883	3	,	,	,
cord-006860-a3b8hyyr	2883	4	4	4	CD
cord-006860-a3b8hyyr	2883	5	nationwide	nationwide	JJ
cord-006860-a3b8hyyr	2883	6	surveys	survey	NNS
cord-006860-a3b8hyyr	2883	7	have	have	VBP
cord-006860-a3b8hyyr	2883	8	been	be	VBN
cord-006860-a3b8hyyr	2883	9	conducted	conduct	VBN
cord-006860-a3b8hyyr	2883	10	.	.	.
cord-006860-a3b8hyyr	2884	1	The	the	DT
cord-006860-a3b8hyyr	2884	2	current	current	JJ
cord-006860-a3b8hyyr	2884	3	incidence	incidence	NN
cord-006860-a3b8hyyr	2884	4	rate	rate	NN
cord-006860-a3b8hyyr	2884	5	is	be	VBZ
cord-006860-a3b8hyyr	2884	6	now	now	RB
cord-006860-a3b8hyyr	2884	7	about	about	RB
cord-006860-a3b8hyyr	2884	8	one	one	CD
cord-006860-a3b8hyyr	2884	9	-	-	HYPH
cord-006860-a3b8hyyr	2884	10	tenth	tenth	NN
cord-006860-a3b8hyyr	2884	11	that	that	IN
cord-006860-a3b8hyyr	2884	12	in	in	IN
cord-006860-a3b8hyyr	2884	13	early	early	JJ
cord-006860-a3b8hyyr	2884	14	1980	1980	CD
cord-006860-a3b8hyyr	2884	15	.	.	.
cord-006860-a3b8hyyr	2885	1	However	however	RB
cord-006860-a3b8hyyr	2885	2	,	,	,
cord-006860-a3b8hyyr	2885	3	in	in	IN
cord-006860-a3b8hyyr	2885	4	a	a	DT
cord-006860-a3b8hyyr	2885	5	small	small	JJ
cord-006860-a3b8hyyr	2885	6	number	number	NN
cord-006860-a3b8hyyr	2885	7	of	of	IN
cord-006860-a3b8hyyr	2885	8	cases	case	NNS
cord-006860-a3b8hyyr	2885	9	,	,	,
cord-006860-a3b8hyyr	2885	10	VK	VK	NNP
cord-006860-a3b8hyyr	2885	11	deficiency	deficiency	NN
cord-006860-a3b8hyyr	2885	12	occured	occur	VBD
cord-006860-a3b8hyyr	2885	13	despite	despite	IN
cord-006860-a3b8hyyr	2885	14	prophylactic	prophylactic	JJ
cord-006860-a3b8hyyr	2885	15	administration	administration	NN
cord-006860-a3b8hyyr	2885	16	during	during	IN
cord-006860-a3b8hyyr	2885	17	the	the	DT
cord-006860-a3b8hyyr	2885	18	neonatal	neonatal	JJ
cord-006860-a3b8hyyr	2885	19	period	period	NN
cord-006860-a3b8hyyr	2885	20	.	.	.
cord-006860-a3b8hyyr	2886	1	In	in	IN
cord-006860-a3b8hyyr	2886	2	order	order	NN
cord-006860-a3b8hyyr	2886	3	to	to	TO
cord-006860-a3b8hyyr	2886	4	clarify	clarify	VB
cord-006860-a3b8hyyr	2886	5	the	the	DT
cord-006860-a3b8hyyr	2886	6	absorption	absorption	NN
cord-006860-a3b8hyyr	2886	7	,	,	,
cord-006860-a3b8hyyr	2886	8	excretion	excretion	NN
cord-006860-a3b8hyyr	2886	9	and	and	CC
cord-006860-a3b8hyyr	2886	10	transplacentel	transplacentel	NN
cord-006860-a3b8hyyr	2886	11	transport	transport	NN
cord-006860-a3b8hyyr	2886	12	of	of	IN
cord-006860-a3b8hyyr	2886	13	VK	VK	NNP
cord-006860-a3b8hyyr	2886	14	in	in	IN
cord-006860-a3b8hyyr	2886	15	the	the	DT
cord-006860-a3b8hyyr	2886	16	perlnatal	perlnatal	JJ
cord-006860-a3b8hyyr	2886	17	period	period	NN
cord-006860-a3b8hyyr	2886	18	,	,	,
cord-006860-a3b8hyyr	2886	19	followlng	followlng	NN
cord-006860-a3b8hyyr	2886	20	studies	study	NNS
cord-006860-a3b8hyyr	2886	21	were	be	VBD
cord-006860-a3b8hyyr	2886	22	carried	carry	VBN
cord-006860-a3b8hyyr	2886	23	out	out	RP
cord-006860-a3b8hyyr	2886	24	.	.	.
cord-006860-a3b8hyyr	2887	1	1)Hepaplastlntest(Normotest	1)hepaplastlntest(normotest	LS
cord-006860-a3b8hyyr	2887	2	)	)	-RRB-
cord-006860-a3b8hyyr	2887	3	were	be	VBD
cord-006860-a3b8hyyr	2887	4	performed	perform	VBN
cord-006860-a3b8hyyr	2887	5	on	on	IN
cord-006860-a3b8hyyr	2887	6	65	65	CD
cord-006860-a3b8hyyr	2887	7	women	woman	NNS
cord-006860-a3b8hyyr	2887	8	in	in	IN
cord-006860-a3b8hyyr	2887	9	the	the	DT
cord-006860-a3b8hyyr	2887	10	last	last	JJ
cord-006860-a3b8hyyr	2887	11	stage	stage	NN
cord-006860-a3b8hyyr	2887	12	of	of	IN
cord-006860-a3b8hyyr	2887	13	pregnancy	pregnancy	NN
cord-006860-a3b8hyyr	2887	14	and	and	CC
cord-006860-a3b8hyyr	2887	15	each	each	DT
cord-006860-a3b8hyyr	2887	16	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2887	17	factor	factor	NN
cord-006860-a3b8hyyr	2887	18	was	be	VBD
cord-006860-a3b8hyyr	2887	19	estimated	estimate	VBN
cord-006860-a3b8hyyr	2887	20	as	as	RB
cord-006860-a3b8hyyr	2887	21	well	well	RB
cord-006860-a3b8hyyr	2887	22	.	.	.
cord-006860-a3b8hyyr	2888	1	2)Correlatlons	2)correlatlons	CD
cord-006860-a3b8hyyr	2888	2	were	be	VBD
cord-006860-a3b8hyyr	2888	3	made	make	VBN
cord-006860-a3b8hyyr	2888	4	between	between	IN
cord-006860-a3b8hyyr	2888	5	mothers'and	mothers'and	NN
cord-006860-a3b8hyyr	2888	6	babies'Hepaplastin	babies'Hepaplastin	NNP
cord-006860-a3b8hyyr	2888	7	test	test	NN
cord-006860-a3b8hyyr	2888	8	values	value	NNS
cord-006860-a3b8hyyr	2888	9	.	.	.
cord-006860-a3b8hyyr	2889	1	3)Transplacental	3)transplacental	CD
cord-006860-a3b8hyyr	2889	2	transport	transport	NN
cord-006860-a3b8hyyr	2889	3	of	of	IN
cord-006860-a3b8hyyr	2889	4	VK	VK	NNP
cord-006860-a3b8hyyr	2889	5	2	2	CD
cord-006860-a3b8hyyr	2889	6	was	be	VBD
cord-006860-a3b8hyyr	2889	7	studied	study	VBN
cord-006860-a3b8hyyr	2889	8	.	.	.
cord-006860-a3b8hyyr	2890	1	The	the	DT
cord-006860-a3b8hyyr	2890	2	general	general	JJ
cord-006860-a3b8hyyr	2890	3	activity	activity	NN
cord-006860-a3b8hyyr	2890	4	of	of	IN
cord-006860-a3b8hyyr	2890	5	VK	VK	NNP
cord-006860-a3b8hyyr	2890	6	dependent	dependent	JJ
cord-006860-a3b8hyyr	2890	7	factors	factor	NNS
cord-006860-a3b8hyyr	2890	8	in	in	IN
cord-006860-a3b8hyyr	2890	9	pregnant	pregnant	JJ
cord-006860-a3b8hyyr	2890	10	women	woman	NNS
cord-006860-a3b8hyyr	2890	11	was	be	VBD
cord-006860-a3b8hyyr	2890	12	much	much	RB
cord-006860-a3b8hyyr	2890	13	higher	high	JJR
cord-006860-a3b8hyyr	2890	14	than	than	IN
cord-006860-a3b8hyyr	2890	15	in	in	IN
cord-006860-a3b8hyyr	2890	16	non	non	JJ
cord-006860-a3b8hyyr	2890	17	pregnant	pregnant	JJ
cord-006860-a3b8hyyr	2890	18	women	woman	NNS
cord-006860-a3b8hyyr	2890	19	.	.	.
cord-006860-a3b8hyyr	2891	1	As	as	RB
cord-006860-a3b8hyyr	2891	2	far	far	RB
cord-006860-a3b8hyyr	2891	3	as	as	IN
cord-006860-a3b8hyyr	2891	4	the	the	DT
cord-006860-a3b8hyyr	2891	5	correlation	correlation	NN
cord-006860-a3b8hyyr	2891	6	between	between	IN
cord-006860-a3b8hyyr	2891	7	mothers'venous	mothers'venous	JJ
cord-006860-a3b8hyyr	2891	8	blood	blood	NN
cord-006860-a3b8hyyr	2891	9	during	during	IN
cord-006860-a3b8hyyr	2891	10	delivery	delivery	NN
cord-006860-a3b8hyyr	2891	11	and	and	CC
cord-006860-a3b8hyyr	2891	12	cordvenous	cordvenous	JJ
cord-006860-a3b8hyyr	2891	13	blood	blood	NN
cord-006860-a3b8hyyr	2891	14	is	be	VBZ
cord-006860-a3b8hyyr	2891	15	concerned	concern	VBN
cord-006860-a3b8hyyr	2891	16	,	,	,
cord-006860-a3b8hyyr	2891	17	in	in	IN
cord-006860-a3b8hyyr	2891	18	the	the	DT
cord-006860-a3b8hyyr	2891	19	group	group	NN
cord-006860-a3b8hyyr	2891	20	of	of	IN
cord-006860-a3b8hyyr	2891	21	mothers	mother	NNS
cord-006860-a3b8hyyr	2891	22	with	with	IN
cord-006860-a3b8hyyr	2891	23	Hepaplastln	Hepaplastln	NNP
cord-006860-a3b8hyyr	2891	24	test	test	NN
cord-006860-a3b8hyyr	2891	25	value	value	NN
cord-006860-a3b8hyyr	2891	26	of	of	IN
cord-006860-a3b8hyyr	2891	27	less	less	JJR
cord-006860-a3b8hyyr	2891	28	than	than	IN
cord-006860-a3b8hyyr	2891	29	120	120	CD
cord-006860-a3b8hyyr	2891	30	%	%	NN
cord-006860-a3b8hyyr	2891	31	of	of	IN
cord-006860-a3b8hyyr	2891	32	the	the	DT
cord-006860-a3b8hyyr	2891	33	normal	normal	JJ
cord-006860-a3b8hyyr	2891	34	adult	adult	NN
cord-006860-a3b8hyyr	2891	35	value	value	NN
cord-006860-a3b8hyyr	2891	36	,	,	,
cord-006860-a3b8hyyr	2891	37	the	the	DT
cord-006860-a3b8hyyr	2891	38	value	value	NN
cord-006860-a3b8hyyr	2891	39	of	of	IN
cord-006860-a3b8hyyr	2891	40	the	the	DT
cord-006860-a3b8hyyr	2891	41	Bepaplastlntest	Bepaplastlntest	NNP
cord-006860-a3b8hyyr	2891	42	was	be	VBD
cord-006860-a3b8hyyr	2891	43	less	less	JJR
cord-006860-a3b8hyyr	2891	44	than	than	IN
cord-006860-a3b8hyyr	2891	45	30	30	CD
cord-006860-a3b8hyyr	2891	46	%	%	NN
cord-006860-a3b8hyyr	2891	47	of	of	IN
cord-006860-a3b8hyyr	2891	48	normal	normal	JJ
cord-006860-a3b8hyyr	2891	49	adult	adult	NN
cord-006860-a3b8hyyr	2891	50	value	value	NN
cord-006860-a3b8hyyr	2891	51	in	in	IN
cord-006860-a3b8hyyr	2891	52	the	the	DT
cord-006860-a3b8hyyr	2891	53	cord	cord	NN
cord-006860-a3b8hyyr	2891	54	venous	venous	JJ
cord-006860-a3b8hyyr	2891	55	blood	blood	NN
cord-006860-a3b8hyyr	2891	56	.	.	.
cord-006860-a3b8hyyr	2892	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2892	2	also	also	RB
cord-006860-a3b8hyyr	2892	3	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	2892	4	that	that	IN
cord-006860-a3b8hyyr	2892	5	VK	VK	NNP
cord-006860-a3b8hyyr	2892	6	passed	pass	VBD
cord-006860-a3b8hyyr	2892	7	through	through	IN
cord-006860-a3b8hyyr	2892	8	the	the	DT
cord-006860-a3b8hyyr	2892	9	placenta	placenta	NN
cord-006860-a3b8hyyr	2892	10	but	but	CC
cord-006860-a3b8hyyr	2892	11	only	only	RB
cord-006860-a3b8hyyr	2892	12	in	in	IN
cord-006860-a3b8hyyr	2892	13	small	small	JJ
cord-006860-a3b8hyyr	2892	14	qualities	quality	NNS
cord-006860-a3b8hyyr	2892	15	.	.	.
cord-006860-a3b8hyyr	2893	1	The	the	DT
cord-006860-a3b8hyyr	2893	2	point	point	NN
cord-006860-a3b8hyyr	2893	3	mutation	mutation	NN
cord-006860-a3b8hyyr	2893	4	G	g	NN
cord-006860-a3b8hyyr	2893	5	to	to	IN
cord-006860-a3b8hyyr	2893	6	A	a	NN
cord-006860-a3b8hyyr	2893	7	at	at	IN
cord-006860-a3b8hyyr	2893	8	nt	nt	RB
cord-006860-a3b8hyyr	2893	9	449	449	CD
cord-006860-a3b8hyyr	2893	10	in	in	IN
cord-006860-a3b8hyyr	2893	11	exon	exon	NN
cord-006860-a3b8hyyr	2893	12	V	v	NN
cord-006860-a3b8hyyr	2893	13	of	of	IN
cord-006860-a3b8hyyr	2893	14	the	the	DT
cord-006860-a3b8hyyr	2893	15	factor	factor	NN
cord-006860-a3b8hyyr	2894	1	X	x	NN
cord-006860-a3b8hyyr	2894	2	gene	gene	NN
cord-006860-a3b8hyyr	2894	3	(	(	-LRB-
cord-006860-a3b8hyyr	2894	4	Gin	Gin	NNP
cord-006860-a3b8hyyr	2894	5	102	102	CD
cord-006860-a3b8hyyr	2894	6	to	to	IN
cord-006860-a3b8hyyr	2894	7	Lys	Lys	NNP
cord-006860-a3b8hyyr	2894	8	)	)	-RRB-
cord-006860-a3b8hyyr	2894	9	has	have	VBZ
cord-006860-a3b8hyyr	2894	10	previously	previously	RB
cord-006860-a3b8hyyr	2894	11	been	be	VBN
cord-006860-a3b8hyyr	2894	12	found	find	VBN
cord-006860-a3b8hyyr	2894	13	in	in	IN
cord-006860-a3b8hyyr	2894	14	two	two	CD
cord-006860-a3b8hyyr	2894	15	independent	independent	JJ
cord-006860-a3b8hyyr	2894	16	kindreds	kindred	NNS
cord-006860-a3b8hyyr	2894	17	with	with	IN
cord-006860-a3b8hyyr	2894	18	FX	FX	NNP
cord-006860-a3b8hyyr	2894	19	deficiency	deficiency	NN
cord-006860-a3b8hyyr	2894	20	.	.	.
cord-006860-a3b8hyyr	2895	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	2895	2	occured	occur	VBD
cord-006860-a3b8hyyr	2895	3	in	in	IN
cord-006860-a3b8hyyr	2895	4	both	both	DT
cord-006860-a3b8hyyr	2895	5	families	family	NNS
cord-006860-a3b8hyyr	2895	6	in	in	IN
cord-006860-a3b8hyyr	2895	7	an	an	DT
cord-006860-a3b8hyyr	2895	8	heterozygote	heterozygote	NN
cord-006860-a3b8hyyr	2895	9	state	state	NN
cord-006860-a3b8hyyr	2895	10	and	and	CC
cord-006860-a3b8hyyr	2895	11	was	be	VBD
cord-006860-a3b8hyyr	2895	12	associated	associate	VBN
cord-006860-a3b8hyyr	2895	13	with	with	IN
cord-006860-a3b8hyyr	2895	14	two	two	CD
cord-006860-a3b8hyyr	2895	15	other	other	JJ
cord-006860-a3b8hyyr	2895	16	genetic	genetic	JJ
cord-006860-a3b8hyyr	2895	17	defect	defect	NN
cord-006860-a3b8hyyr	2895	18	in	in	IN
cord-006860-a3b8hyyr	2895	19	the	the	DT
cord-006860-a3b8hyyr	2895	20	FX	FX	NNP
cord-006860-a3b8hyyr	2895	21	gene	gene	NN
cord-006860-a3b8hyyr	2895	22	.	.	.
cord-006860-a3b8hyyr	2896	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2896	2	have	have	VBP
cord-006860-a3b8hyyr	2896	3	identified	identify	VBN
cord-006860-a3b8hyyr	2896	4	another	another	DT
cord-006860-a3b8hyyr	2896	5	familiy	familiy	NN
cord-006860-a3b8hyyr	2896	6	in	in	IN
cord-006860-a3b8hyyr	2896	7	which	which	WDT
cord-006860-a3b8hyyr	2896	8	this	this	DT
cord-006860-a3b8hyyr	2896	9	mutation	mutation	NN
cord-006860-a3b8hyyr	2896	10	occurs	occur	VBZ
cord-006860-a3b8hyyr	2896	11	in	in	IN
cord-006860-a3b8hyyr	2896	12	a	a	DT
cord-006860-a3b8hyyr	2896	13	homozygote	homozygote	NN
cord-006860-a3b8hyyr	2896	14	state	state	NN
cord-006860-a3b8hyyr	2896	15	.	.	.
cord-006860-a3b8hyyr	2897	1	In	in	IN
cord-006860-a3b8hyyr	2897	2	this	this	DT
cord-006860-a3b8hyyr	2897	3	family	family	NN
cord-006860-a3b8hyyr	2897	4	the	the	DT
cord-006860-a3b8hyyr	2897	5	mutation	mutation	NN
cord-006860-a3b8hyyr	2897	6	is	be	VBZ
cord-006860-a3b8hyyr	2897	7	associated	associate	VBN
cord-006860-a3b8hyyr	2897	8	with	with	IN
cord-006860-a3b8hyyr	2897	9	the	the	DT
cord-006860-a3b8hyyr	2897	10	previously	previously	RB
cord-006860-a3b8hyyr	2897	11	reported	report	VBN
cord-006860-a3b8hyyr	2897	12	mutation	mutation	NN
cord-006860-a3b8hyyr	2897	13	Gla	Gla	NNP
cord-006860-a3b8hyyr	2897	14	14	14	CD
cord-006860-a3b8hyyr	2897	15	to	to	IN
cord-006860-a3b8hyyr	2897	16	Lys	Lys	NNP
cord-006860-a3b8hyyr	2897	17	which	which	WDT
cord-006860-a3b8hyyr	2897	18	also	also	RB
cord-006860-a3b8hyyr	2897	19	occurs	occur	VBZ
cord-006860-a3b8hyyr	2897	20	in	in	IN
cord-006860-a3b8hyyr	2897	21	a	a	DT
cord-006860-a3b8hyyr	2897	22	homozygote	homozygote	NN
cord-006860-a3b8hyyr	2897	23	state	state	NN
cord-006860-a3b8hyyr	2897	24	.	.	.
cord-006860-a3b8hyyr	2898	1	The	the	DT
cord-006860-a3b8hyyr	2898	2	PT	PT	NNP
cord-006860-a3b8hyyr	2898	3	and	and	CC
cord-006860-a3b8hyyr	2898	4	PTT	PTT	NNP
cord-006860-a3b8hyyr	2898	5	of	of	IN
cord-006860-a3b8hyyr	2898	6	the	the	DT
cord-006860-a3b8hyyr	2898	7	proposita	proposita	NNP
cord-006860-a3b8hyyr	2898	8	and	and	CC
cord-006860-a3b8hyyr	2898	9	her	-PRON-	PRP$
cord-006860-a3b8hyyr	2898	10	siter	siter	NN
cord-006860-a3b8hyyr	2898	11	are	be	VBP
cord-006860-a3b8hyyr	2898	12	markedly	markedly	RB
cord-006860-a3b8hyyr	2898	13	prolonged	prolong	VBN
cord-006860-a3b8hyyr	2898	14	.	.	.
cord-006860-a3b8hyyr	2899	1	The	the	DT
cord-006860-a3b8hyyr	2899	2	FX	FX	NNP
cord-006860-a3b8hyyr	2899	3	activity	activity	NN
cord-006860-a3b8hyyr	2899	4	is	be	VBZ
cord-006860-a3b8hyyr	2899	5	reduced	reduce	VBN
cord-006860-a3b8hyyr	2899	6	to	to	IN
cord-006860-a3b8hyyr	2899	7	<	<	XX
cord-006860-a3b8hyyr	2899	8	1	1	CD
cord-006860-a3b8hyyr	2899	9	%	%	NN
cord-006860-a3b8hyyr	2899	10	in	in	IN
cord-006860-a3b8hyyr	2899	11	the	the	DT
cord-006860-a3b8hyyr	2899	12	extrinsic	extrinsic	JJ
cord-006860-a3b8hyyr	2899	13	system	system	NN
cord-006860-a3b8hyyr	2899	14	,	,	,
cord-006860-a3b8hyyr	2899	15	to	to	IN
cord-006860-a3b8hyyr	2899	16	30	30	CD
cord-006860-a3b8hyyr	2899	17	%	%	NN
cord-006860-a3b8hyyr	2899	18	in	in	IN
cord-006860-a3b8hyyr	2899	19	the	the	DT
cord-006860-a3b8hyyr	2899	20	intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	2899	21	system	system	NN
cord-006860-a3b8hyyr	2899	22	and	and	CC
cord-006860-a3b8hyyr	2899	23	to	to	IN
cord-006860-a3b8hyyr	2899	24	18	18	CD
cord-006860-a3b8hyyr	2899	25	%	%	NN
cord-006860-a3b8hyyr	2899	26	after	after	IN
cord-006860-a3b8hyyr	2899	27	activation	activation	NN
cord-006860-a3b8hyyr	2899	28	with	with	IN
cord-006860-a3b8hyyr	2899	29	RVV	RVV	NNP
cord-006860-a3b8hyyr	2899	30	.	.	.
cord-006860-a3b8hyyr	2900	1	The	the	DT
cord-006860-a3b8hyyr	2900	2	FX	FX	NNP
cord-006860-a3b8hyyr	2900	3	antigen	antigen	NN
cord-006860-a3b8hyyr	2900	4	is	be	VBZ
cord-006860-a3b8hyyr	2900	5	reduced	reduce	VBN
cord-006860-a3b8hyyr	2900	6	to	to	IN
cord-006860-a3b8hyyr	2900	7	20	20	CD
cord-006860-a3b8hyyr	2900	8	%	%	NN
cord-006860-a3b8hyyr	2900	9	.	.	.
cord-006860-a3b8hyyr	2901	1	The	the	DT
cord-006860-a3b8hyyr	2901	2	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2901	3	profile	profile	NN
cord-006860-a3b8hyyr	2901	4	of	of	IN
cord-006860-a3b8hyyr	2901	5	this	this	DT
cord-006860-a3b8hyyr	2901	6	family	family	NN
cord-006860-a3b8hyyr	2901	7	thus	thus	RB
cord-006860-a3b8hyyr	2901	8	is	be	VBZ
cord-006860-a3b8hyyr	2901	9	identical	identical	JJ
cord-006860-a3b8hyyr	2901	10	with	with	IN
cord-006860-a3b8hyyr	2901	11	that	that	DT
cord-006860-a3b8hyyr	2901	12	of	of	IN
cord-006860-a3b8hyyr	2901	13	FX	FX	NNP
cord-006860-a3b8hyyr	2901	14	Vorarlberg	Vorarlberg	NNP
cord-006860-a3b8hyyr	2901	15	despite	despite	IN
cord-006860-a3b8hyyr	2901	16	the	the	DT
cord-006860-a3b8hyyr	2901	17	fact	fact	NN
cord-006860-a3b8hyyr	2901	18	that	that	IN
cord-006860-a3b8hyyr	2901	19	the	the	DT
cord-006860-a3b8hyyr	2901	20	FX	FX	NNP
cord-006860-a3b8hyyr	2901	21	Vorarlberg	Vorarlberg	NNP
cord-006860-a3b8hyyr	2901	22	kindred	kindred	NN
cord-006860-a3b8hyyr	2901	23	is	be	VBZ
cord-006860-a3b8hyyr	2901	24	only	only	RB
cord-006860-a3b8hyyr	2901	25	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	2901	26	for	for	IN
cord-006860-a3b8hyyr	2901	27	the	the	DT
cord-006860-a3b8hyyr	2901	28	mutation	mutation	NN
cord-006860-a3b8hyyr	2901	29	Glal02	Glal02	VBN
cord-006860-a3b8hyyr	2901	30	to	to	IN
cord-006860-a3b8hyyr	2901	31	Lys	Lys	NNP
cord-006860-a3b8hyyr	2901	32	.	.	.
cord-006860-a3b8hyyr	2902	1	Haplotype	Haplotype	NNP
cord-006860-a3b8hyyr	2902	2	analysis	analysis	NN
cord-006860-a3b8hyyr	2902	3	could	could	MD
cord-006860-a3b8hyyr	2902	4	not	not	RB
cord-006860-a3b8hyyr	2902	5	rule	rule	VB
cord-006860-a3b8hyyr	2902	6	out	out	RP
cord-006860-a3b8hyyr	2902	7	consanquinity	consanquinity	NN
cord-006860-a3b8hyyr	2902	8	with	with	IN
cord-006860-a3b8hyyr	2902	9	the	the	DT
cord-006860-a3b8hyyr	2902	10	FX	FX	NNP
cord-006860-a3b8hyyr	2902	11	Vorarlberg	Vorarlberg	NNP
cord-006860-a3b8hyyr	2902	12	kindred	kindred	NN
cord-006860-a3b8hyyr	2902	13	.	.	.
cord-006860-a3b8hyyr	2903	1	These	these	DT
cord-006860-a3b8hyyr	2903	2	data	datum	NNS
cord-006860-a3b8hyyr	2903	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	2903	4	that	that	IN
cord-006860-a3b8hyyr	2903	5	the	the	DT
cord-006860-a3b8hyyr	2903	6	mutation	mutation	NN
cord-006860-a3b8hyyr	2903	7	at	at	IN
cord-006860-a3b8hyyr	2903	8	nt	nt	RB
cord-006860-a3b8hyyr	2903	9	449	449	CD
cord-006860-a3b8hyyr	2903	10	which	which	WDT
cord-006860-a3b8hyyr	2903	11	leads	lead	VBZ
cord-006860-a3b8hyyr	2903	12	to	to	IN
cord-006860-a3b8hyyr	2903	13	a	a	DT
cord-006860-a3b8hyyr	2903	14	fairly	fairly	RB
cord-006860-a3b8hyyr	2903	15	dramatic	dramatic	JJ
cord-006860-a3b8hyyr	2903	16	amino	amino	NN
cord-006860-a3b8hyyr	2903	17	acid	acid	NN
cord-006860-a3b8hyyr	2903	18	change	change	NN
cord-006860-a3b8hyyr	2903	19	from	from	IN
cord-006860-a3b8hyyr	2903	20	Glu	Glu	NNP
cord-006860-a3b8hyyr	2903	21	to	to	IN
cord-006860-a3b8hyyr	2903	22	Lys	Lys	NNP
cord-006860-a3b8hyyr	2903	23	would	would	MD
cord-006860-a3b8hyyr	2903	24	indeed	indeed	RB
cord-006860-a3b8hyyr	2903	25	represent	represent	VB
cord-006860-a3b8hyyr	2903	26	a	a	DT
cord-006860-a3b8hyyr	2903	27	polymorphism	polymorphism	NN
cord-006860-a3b8hyyr	2903	28	.	.	.
cord-006860-a3b8hyyr	2904	1	To	to	TO
cord-006860-a3b8hyyr	2904	2	further	further	RB
cord-006860-a3b8hyyr	2904	3	address	address	VB
cord-006860-a3b8hyyr	2904	4	this	this	DT
cord-006860-a3b8hyyr	2904	5	question	question	NN
cord-006860-a3b8hyyr	2904	6	we	-PRON-	PRP
cord-006860-a3b8hyyr	2904	7	cloned	clone	VBD
cord-006860-a3b8hyyr	2904	8	the	the	DT
cord-006860-a3b8hyyr	2904	9	FX	FX	NNP
cord-006860-a3b8hyyr	2904	10	gene	gene	NN
cord-006860-a3b8hyyr	2904	11	in	in	IN
cord-006860-a3b8hyyr	2904	12	an	an	DT
cord-006860-a3b8hyyr	2904	13	expression	expression	NN
cord-006860-a3b8hyyr	2904	14	vector	vector	NN
cord-006860-a3b8hyyr	2904	15	(	(	-LRB-
cord-006860-a3b8hyyr	2904	16	pCEP	pCEP	NNP
cord-006860-a3b8hyyr	2904	17	4	4	CD
cord-006860-a3b8hyyr	2904	18	)	)	-RRB-
cord-006860-a3b8hyyr	2904	19	for	for	IN
cord-006860-a3b8hyyr	2904	20	transient	transient	JJ
cord-006860-a3b8hyyr	2904	21	expression	expression	NN
cord-006860-a3b8hyyr	2904	22	in	in	IN
cord-006860-a3b8hyyr	2904	23	the	the	DT
cord-006860-a3b8hyyr	2904	24	human	human	JJ
cord-006860-a3b8hyyr	2904	25	embryonic	embryonic	JJ
cord-006860-a3b8hyyr	2904	26	kidney	kidney	NN
cord-006860-a3b8hyyr	2904	27	cell	cell	NN
cord-006860-a3b8hyyr	2904	28	line	line	NN
cord-006860-a3b8hyyr	2904	29	293	293	CD
cord-006860-a3b8hyyr	2904	30	and	and	CC
cord-006860-a3b8hyyr	2904	31	introduced	introduce	VBD
cord-006860-a3b8hyyr	2904	32	the	the	DT
cord-006860-a3b8hyyr	2904	33	mutation	mutation	NN
cord-006860-a3b8hyyr	2904	34	at	at	IN
cord-006860-a3b8hyyr	2904	35	nt	nt	RB
cord-006860-a3b8hyyr	2904	36	449	449	CD
cord-006860-a3b8hyyr	2904	37	by	by	IN
cord-006860-a3b8hyyr	2904	38	site	site	NN
cord-006860-a3b8hyyr	2904	39	directed	direct	VBN
cord-006860-a3b8hyyr	2904	40	mutagenesis	mutagenesis	NN
cord-006860-a3b8hyyr	2904	41	.	.	.
cord-006860-a3b8hyyr	2905	1	Hereditary	hereditary	JJ
cord-006860-a3b8hyyr	2905	2	deficiency	deficiency	NN
cord-006860-a3b8hyyr	2905	3	of	of	IN
cord-006860-a3b8hyyr	2905	4	factor	factor	NN
cord-006860-a3b8hyyr	2905	5	IXa	IXa	NNS
cord-006860-a3b8hyyr	2905	6	,	,	,
cord-006860-a3b8hyyr	2905	7	a	a	DT
cord-006860-a3b8hyyr	2905	8	key	key	JJ
cord-006860-a3b8hyyr	2905	9	enzyme	enzyme	NN
cord-006860-a3b8hyyr	2905	10	in	in	IN
cord-006860-a3b8hyyr	2905	11	blood	blood	NN
cord-006860-a3b8hyyr	2905	12	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2905	13	,	,	,
cord-006860-a3b8hyyr	2905	14	causes	cause	VBZ
cord-006860-a3b8hyyr	2905	15	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	2905	16	B	B	NNP
cord-006860-a3b8hyyr	2905	17	,	,	,
cord-006860-a3b8hyyr	2905	18	a	a	DT
cord-006860-a3b8hyyr	2905	19	severe	severe	JJ
cord-006860-a3b8hyyr	2905	20	X	x	NN
cord-006860-a3b8hyyr	2905	21	-	-	JJ
cord-006860-a3b8hyyr	2905	22	chromosomelinked	chromosomelinked	JJ
cord-006860-a3b8hyyr	2905	23	bleeding	bleeding	NN
cord-006860-a3b8hyyr	2905	24	disorder	disorder	NN
cord-006860-a3b8hyyr	2905	25	;	;	,
cord-006860-a3b8hyyr	2905	26	clinical	clinical	JJ
cord-006860-a3b8hyyr	2905	27	studies	study	NNS
cord-006860-a3b8hyyr	2905	28	have	have	VBP
cord-006860-a3b8hyyr	2905	29	identified	identify	VBN
cord-006860-a3b8hyyr	2905	30	nearly	nearly	RB
cord-006860-a3b8hyyr	2905	31	500	500	CD
cord-006860-a3b8hyyr	2905	32	deleterious	deleterious	JJ
cord-006860-a3b8hyyr	2905	33	variants	variant	NNS
cord-006860-a3b8hyyr	2905	34	.	.	.
cord-006860-a3b8hyyr	2906	1	The	the	DT
cord-006860-a3b8hyyr	2906	2	x	x	NN
cord-006860-a3b8hyyr	2906	3	-	-	NN
cord-006860-a3b8hyyr	2906	4	ray	ray	JJ
cord-006860-a3b8hyyr	2906	5	structure	structure	NN
cord-006860-a3b8hyyr	2906	6	of	of	IN
cord-006860-a3b8hyyr	2906	7	porcine	porcine	JJ
cord-006860-a3b8hyyr	2906	8	factor	factor	NN
cord-006860-a3b8hyyr	2906	9	IXa	IXa	NNS
cord-006860-a3b8hyyr	2906	10	shows	show	VBZ
cord-006860-a3b8hyyr	2906	11	the	the	DT
cord-006860-a3b8hyyr	2906	12	atomic	atomic	JJ
cord-006860-a3b8hyyr	2906	13	origins	origin	NNS
cord-006860-a3b8hyyr	2906	14	of	of	IN
cord-006860-a3b8hyyr	2906	15	the	the	DT
cord-006860-a3b8hyyr	2906	16	disease	disease	NN
cord-006860-a3b8hyyr	2906	17	,	,	,
cord-006860-a3b8hyyr	2906	18	while	while	IN
cord-006860-a3b8hyyr	2906	19	the	the	DT
cord-006860-a3b8hyyr	2906	20	spatial	spatial	JJ
cord-006860-a3b8hyyr	2906	21	distribution	distribution	NN
cord-006860-a3b8hyyr	2906	22	of	of	IN
cord-006860-a3b8hyyr	2906	23	mutation	mutation	NN
cord-006860-a3b8hyyr	2906	24	sites	site	NNS
cord-006860-a3b8hyyr	2906	25	suggests	suggest	VBZ
cord-006860-a3b8hyyr	2906	26	a	a	DT
cord-006860-a3b8hyyr	2906	27	structural	structural	JJ
cord-006860-a3b8hyyr	2906	28	model	model	NN
cord-006860-a3b8hyyr	2906	29	for	for	IN
cord-006860-a3b8hyyr	2906	30	fX	fX	NNP
cord-006860-a3b8hyyr	2906	31	activation	activation	NN
cord-006860-a3b8hyyr	2906	32	by	by	IN
cord-006860-a3b8hyyr	2906	33	phospholipid	phospholipid	NN
cord-006860-a3b8hyyr	2906	34	-	-	HYPH
cord-006860-a3b8hyyr	2906	35	bound	bind	VBN
cord-006860-a3b8hyyr	2906	36	flXa	flxa	NN
cord-006860-a3b8hyyr	2906	37	and	and	CC
cord-006860-a3b8hyyr	2906	38	cofactor	cofactor	NN
cord-006860-a3b8hyyr	2906	39	Villa	Villa	NNP
cord-006860-a3b8hyyr	2906	40	.	.	.
cord-006860-a3b8hyyr	2907	1	The	the	DT
cord-006860-a3b8hyyr	2907	2	3.0	3.0	CD
cord-006860-a3b8hyyr	2907	3	A	a	DT
cord-006860-a3b8hyyr	2907	4	resolution	resolution	NN
cord-006860-a3b8hyyr	2907	5	diffraction	diffraction	NN
cord-006860-a3b8hyyr	2907	6	data	datum	NNS
cord-006860-a3b8hyyr	2907	7	clearly	clearly	RB
cord-006860-a3b8hyyr	2907	8	show	show	VBP
cord-006860-a3b8hyyr	2907	9	the	the	DT
cord-006860-a3b8hyyr	2907	10	structures	structure	NNS
cord-006860-a3b8hyyr	2907	11	of	of	IN
cord-006860-a3b8hyyr	2907	12	the	the	DT
cord-006860-a3b8hyyr	2907	13	serine	serine	JJ
cord-006860-a3b8hyyr	2907	14	proteinase	proteinase	NN
cord-006860-a3b8hyyr	2907	15	module	module	NN
cord-006860-a3b8hyyr	2907	16	and	and	CC
cord-006860-a3b8hyyr	2907	17	the	the	DT
cord-006860-a3b8hyyr	2907	18	two	two	CD
cord-006860-a3b8hyyr	2907	19	preceding	precede	VBG
cord-006860-a3b8hyyr	2907	20	epidermal	epidermal	JJ
cord-006860-a3b8hyyr	2907	21	growth	growth	NN
cord-006860-a3b8hyyr	2907	22	factor	factor	NN
cord-006860-a3b8hyyr	2907	23	(	(	-LRB-
cord-006860-a3b8hyyr	2907	24	EGF)-like	egf)-like	NN
cord-006860-a3b8hyyr	2907	25	modules	module	NNS
cord-006860-a3b8hyyr	2907	26	;	;	:
cord-006860-a3b8hyyr	2907	27	the	the	DT
cord-006860-a3b8hyyr	2907	28	N	N	NNP
cord-006860-a3b8hyyr	2907	29	-	-	HYPH
cord-006860-a3b8hyyr	2907	30	terminal	terminal	NN
cord-006860-a3b8hyyr	2907	31	Gla	Gla	NNP
cord-006860-a3b8hyyr	2907	32	module	module	NN
cord-006860-a3b8hyyr	2907	33	is	be	VBZ
cord-006860-a3b8hyyr	2907	34	partially	partially	RB
cord-006860-a3b8hyyr	2907	35	disordered	disordered	JJ
cord-006860-a3b8hyyr	2907	36	.	.	.
cord-006860-a3b8hyyr	2908	1	The	the	DT
cord-006860-a3b8hyyr	2908	2	catalytic	catalytic	JJ
cord-006860-a3b8hyyr	2908	3	module	module	NN
cord-006860-a3b8hyyr	2908	4	,	,	,
cord-006860-a3b8hyyr	2908	5	with	with	IN
cord-006860-a3b8hyyr	2908	6	covalent	covalent	JJ
cord-006860-a3b8hyyr	2908	7	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2908	8	D	D	NNP
cord-006860-a3b8hyyr	2908	9	-	-	HYPH
cord-006860-a3b8hyyr	2908	10	Phe	Phe	NNP
cord-006860-a3b8hyyr	2908	11	-	-	HYPH
cord-006860-a3b8hyyr	2908	12	Pro	pro	JJ
cord-006860-a3b8hyyr	2908	13	-	-	JJ
cord-006860-a3b8hyyr	2908	14	Arg	arg	JJ
cord-006860-a3b8hyyr	2908	15	chloromethyl	chloromethyl	NN
cord-006860-a3b8hyyr	2908	16	ketone	ketone	NN
cord-006860-a3b8hyyr	2908	17	,	,	,
cord-006860-a3b8hyyr	2908	18	most	most	RBS
cord-006860-a3b8hyyr	2908	19	closely	closely	RB
cord-006860-a3b8hyyr	2908	20	resembles	resemble	VBZ
cord-006860-a3b8hyyr	2908	21	fXa	fxa	NN
cord-006860-a3b8hyyr	2908	22	but	but	CC
cord-006860-a3b8hyyr	2908	23	differs	differ	VBZ
cord-006860-a3b8hyyr	2908	24	significantly	significantly	RB
cord-006860-a3b8hyyr	2908	25	at	at	IN
cord-006860-a3b8hyyr	2908	26	several	several	JJ
cord-006860-a3b8hyyr	2908	27	positions	position	NNS
cord-006860-a3b8hyyr	2908	28	.	.	.
cord-006860-a3b8hyyr	2909	1	Particularly	particularly	RB
cord-006860-a3b8hyyr	2909	2	noteworthy	noteworthy	JJ
cord-006860-a3b8hyyr	2909	3	is	be	VBZ
cord-006860-a3b8hyyr	2909	4	the	the	DT
cord-006860-a3b8hyyr	2909	5	strained	strained	JJ
cord-006860-a3b8hyyr	2909	6	conformation	conformation	NN
cord-006860-a3b8hyyr	2909	7	of	of	IN
cord-006860-a3b8hyyr	2909	8	Glu-388	Glu-388	NNP
cord-006860-a3b8hyyr	2909	9	,	,	,
cord-006860-a3b8hyyr	2909	10	a	a	DT
cord-006860-a3b8hyyr	2909	11	residue	residue	NN
cord-006860-a3b8hyyr	2909	12	strictly	strictly	RB
cord-006860-a3b8hyyr	2909	13	conserved	conserve	VBN
cord-006860-a3b8hyyr	2909	14	in	in	IN
cord-006860-a3b8hyyr	2909	15	known	know	VBN
cord-006860-a3b8hyyr	2909	16	fIXa	fixa	NN
cord-006860-a3b8hyyr	2909	17	sequences	sequence	NNS
cord-006860-a3b8hyyr	2909	18	but	but	CC
cord-006860-a3b8hyyr	2909	19	conserved	conserve	VBN
cord-006860-a3b8hyyr	2909	20	as	as	IN
cord-006860-a3b8hyyr	2909	21	Gly	Gly	NNP
cord-006860-a3b8hyyr	2909	22	among	among	IN
cord-006860-a3b8hyyr	2909	23	other	other	JJ
cord-006860-a3b8hyyr	2909	24	trypsin	trypsin	NN
cord-006860-a3b8hyyr	2909	25	-	-	HYPH
cord-006860-a3b8hyyr	2909	26	like	like	JJ
cord-006860-a3b8hyyr	2909	27	serine	serine	NN
cord-006860-a3b8hyyr	2909	28	proteinase	proteinase	NN
cord-006860-a3b8hyyr	2909	29	.	.	.
cord-006860-a3b8hyyr	2910	1	Flexibility	flexibility	NN
cord-006860-a3b8hyyr	2910	2	apparent	apparent	JJ
cord-006860-a3b8hyyr	2910	3	in	in	IN
cord-006860-a3b8hyyr	2910	4	electron	electron	NN
cord-006860-a3b8hyyr	2910	5	density	density	NN
cord-006860-a3b8hyyr	2910	6	together	together	RB
cord-006860-a3b8hyyr	2910	7	with	with	IN
cord-006860-a3b8hyyr	2910	8	modelling	modelling	NN
cord-006860-a3b8hyyr	2910	9	studies	study	NNS
cord-006860-a3b8hyyr	2910	10	suggests	suggest	VBZ
cord-006860-a3b8hyyr	2910	11	that	that	IN
cord-006860-a3b8hyyr	2910	12	this	this	DT
cord-006860-a3b8hyyr	2910	13	may	may	MD
cord-006860-a3b8hyyr	2910	14	cause	cause	VB
cord-006860-a3b8hyyr	2910	15	incomplete	incomplete	JJ
cord-006860-a3b8hyyr	2910	16	active	active	JJ
cord-006860-a3b8hyyr	2910	17	site	site	NN
cord-006860-a3b8hyyr	2910	18	formation	formation	NN
cord-006860-a3b8hyyr	2910	19	,	,	,
cord-006860-a3b8hyyr	2910	20	even	even	RB
cord-006860-a3b8hyyr	2910	21	after	after	IN
cord-006860-a3b8hyyr	2910	22	zymogen	zymogen	NNP
cord-006860-a3b8hyyr	2910	23	activation	activation	NNP
cord-006860-a3b8hyyr	2910	24	,	,	,
cord-006860-a3b8hyyr	2910	25	and	and	CC
cord-006860-a3b8hyyr	2910	26	hence	hence	RB
cord-006860-a3b8hyyr	2910	27	the	the	DT
cord-006860-a3b8hyyr	2910	28	low	low	JJ
cord-006860-a3b8hyyr	2910	29	catalytic	catalytic	JJ
cord-006860-a3b8hyyr	2910	30	activity	activity	NN
cord-006860-a3b8hyyr	2910	31	of	of	IN
cord-006860-a3b8hyyr	2910	32	fixa	fixa	NNP
cord-006860-a3b8hyyr	2910	33	.	.	.
cord-006860-a3b8hyyr	2911	1	Most	Most	JJS
cord-006860-a3b8hyyr	2911	2	hemophilic	hemophilic	JJ
cord-006860-a3b8hyyr	2911	3	mutation	mutation	NN
cord-006860-a3b8hyyr	2911	4	sites	site	NNS
cord-006860-a3b8hyyr	2911	5	of	of	IN
cord-006860-a3b8hyyr	2911	6	surface	surface	NN
cord-006860-a3b8hyyr	2911	7	fiX	fix	JJ
cord-006860-a3b8hyyr	2911	8	residues	residue	NNS
cord-006860-a3b8hyyr	2911	9	occur	occur	VBP
cord-006860-a3b8hyyr	2911	10	on	on	IN
cord-006860-a3b8hyyr	2911	11	the	the	DT
cord-006860-a3b8hyyr	2911	12	concave	concave	JJ
cord-006860-a3b8hyyr	2911	13	surface	surface	NN
cord-006860-a3b8hyyr	2911	14	of	of	IN
cord-006860-a3b8hyyr	2911	15	the	the	DT
cord-006860-a3b8hyyr	2911	16	bent	bent	JJ
cord-006860-a3b8hyyr	2911	17	molecule	molecule	NN
cord-006860-a3b8hyyr	2911	18	and	and	CC
cord-006860-a3b8hyyr	2911	19	suggest	suggest	VBP
cord-006860-a3b8hyyr	2911	20	a	a	DT
cord-006860-a3b8hyyr	2911	21	plausible	plausible	JJ
cord-006860-a3b8hyyr	2911	22	model	model	NN
cord-006860-a3b8hyyr	2911	23	for	for	IN
cord-006860-a3b8hyyr	2911	24	the	the	DT
cord-006860-a3b8hyyr	2911	25	membrane	membrane	NN
cord-006860-a3b8hyyr	2911	26	-	-	HYPH
cord-006860-a3b8hyyr	2911	27	bound	bind	VBN
cord-006860-a3b8hyyr	2911	28	ternary	ternary	JJ
cord-006860-a3b8hyyr	2911	29	flXa	flxa	NN
cord-006860-a3b8hyyr	2911	30	-	-	HYPH
cord-006860-a3b8hyyr	2911	31	fVIlla	fvilla	CD
cord-006860-a3b8hyyr	2911	32	-	-	HYPH
cord-006860-a3b8hyyr	2911	33	fX	fX	''
cord-006860-a3b8hyyr	2911	34	complex	complex	JJ
cord-006860-a3b8hyyr	2911	35	structure	structure	NN
cord-006860-a3b8hyyr	2911	36	:	:	:
cord-006860-a3b8hyyr	2911	37	the	the	DT
cord-006860-a3b8hyyr	2911	38	stabilizing	stabilize	VBG
cord-006860-a3b8hyyr	2911	39	fVIlla	fvilla	ADD
cord-006860-a3b8hyyr	2911	40	interactions	interaction	NNS
cord-006860-a3b8hyyr	2911	41	force	force	VBP
cord-006860-a3b8hyyr	2911	42	the	the	DT
cord-006860-a3b8hyyr	2911	43	catalytic	catalytic	JJ
cord-006860-a3b8hyyr	2911	44	modules	module	NNS
cord-006860-a3b8hyyr	2911	45	together	together	RB
cord-006860-a3b8hyyr	2911	46	,	,	,
cord-006860-a3b8hyyr	2911	47	completing	complete	VBG
cord-006860-a3b8hyyr	2911	48	flXa	flxa	XX
cord-006860-a3b8hyyr	2911	49	active	active	JJ
cord-006860-a3b8hyyr	2911	50	site	site	NN
cord-006860-a3b8hyyr	2911	51	formation	formation	NN
cord-006860-a3b8hyyr	2911	52	and	and	CC
cord-006860-a3b8hyyr	2911	53	catalytic	catalytic	JJ
cord-006860-a3b8hyyr	2911	54	enhancement	enhancement	NN
cord-006860-a3b8hyyr	2911	55	.	.	.
cord-006860-a3b8hyyr	2912	1	FACTOR	factor	NN
cord-006860-a3b8hyyr	2913	1	X	X	NNP
cord-006860-a3b8hyyr	2913	2	FRANKFURT	FRANKFURT	NNP
cord-006860-a3b8hyyr	2914	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	2914	2	MOLECULAR	MOLECULAR	NNP
cord-006860-a3b8hyyr	2914	3	AND	and	CC
cord-006860-a3b8hyyr	2914	4	FUNCTIONAL	functional	JJ
cord-006860-a3b8hyyr	2914	5	CHARACTERISATION	CHARACTERISATION	NNS
cord-006860-a3b8hyyr	2914	6	OF	of	IN
cord-006860-a3b8hyyr	2914	7	A	a	DT
cord-006860-a3b8hyyr	2914	8	HEREDITARY	hereditary	JJ
cord-006860-a3b8hyyr	2914	9	FACTOR	factor	NN
cord-006860-a3b8hyyr	2915	1	X	X	NNP
cord-006860-a3b8hyyr	2915	2	DEFECT	DEFECT	NNP
cord-006860-a3b8hyyr	2915	3	(	(	-LRB-
cord-006860-a3b8hyyr	2915	4	GLA	GLA	NNP
cord-006860-a3b8hyyr	2915	5	+25	+25	NNP
cord-006860-a3b8hyyr	2915	6	---	---	:
cord-006860-a3b8hyyr	2915	7	,	,	,
cord-006860-a3b8hyyr	2915	8	LYS	LYS	NNP
cord-006860-a3b8hyyr	2915	9	)	)	-RRB-
cord-006860-a3b8hyyr	2916	1	Huhmann	Huhmann	NNP
cord-006860-a3b8hyyr	2916	2	I.	I.	NNP
cord-006860-a3b8hyyr	2916	3	,	,	,
cord-006860-a3b8hyyr	2916	4	HOller	HOller	NNP
cord-006860-a3b8hyyr	2916	5	B.	B.	NNP
cord-006860-a3b8hyyr	2916	6	,	,	,
cord-006860-a3b8hyyr	2916	7	Krinninger	Krinninger	NNP
cord-006860-a3b8hyyr	2916	8	B.	B.	NNP
cord-006860-a3b8hyyr	2916	9	,	,	,
cord-006860-a3b8hyyr	2917	1	Turecek	Turecek	NNP
cord-006860-a3b8hyyr	2917	2	Pi	Pi	NNP
cord-006860-a3b8hyyr	2917	3	.	.	.
cord-006860-a3b8hyyr	2918	1	,	,	,
cord-006860-a3b8hyyr	2918	2	Richter	Richter	NNP
cord-006860-a3b8hyyr	2918	3	G.	G.	NNP
cord-006860-a3b8hyyr	2918	4	,	,	,
cord-006860-a3b8hyyr	2918	5	Scharrer	Scharrer	NNP
cord-006860-a3b8hyyr	2918	6	I.	I.	NNP
cord-006860-a3b8hyyr	2918	7	,	,	,
cord-006860-a3b8hyyr	2918	8	Forberg	Forberg	NNP
cord-006860-a3b8hyyr	2918	9	E.	E.	NNP
cord-006860-a3b8hyyr	2918	10	,	,	,
cord-006860-a3b8hyyr	2919	1	Watzke	Watzke	NNP
cord-006860-a3b8hyyr	2919	2	H	H	NNP
cord-006860-a3b8hyyr	2919	3	..	..	NFP
cord-006860-a3b8hyyr	2919	4	Univ	Univ	NNP
cord-006860-a3b8hyyr	2919	5	.	.	.
cord-006860-a3b8hyyr	2920	1	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	2920	2	ftlr	ftlr	NNP
cord-006860-a3b8hyyr	2920	3	Innere	Innere	NNP
cord-006860-a3b8hyyr	2920	4	Medi	Medi	NNP
cord-006860-a3b8hyyr	2920	5	,	,	,
cord-006860-a3b8hyyr	2920	6	Abteilung	Abteilung	NNP
cord-006860-a3b8hyyr	2920	7	for	for	IN
cord-006860-a3b8hyyr	2920	8	H~	H~	NNP
cord-006860-a3b8hyyr	2921	1	matoiogie	matoiogie	NNP
cord-006860-a3b8hyyr	2921	2	und	und	IN
cord-006860-a3b8hyyr	2921	3	Hamostaseologie	Hamostaseologie	NNP
cord-006860-a3b8hyyr	2921	4	,	,	,
cord-006860-a3b8hyyr	2921	5	W	W	NNP
cord-006860-a3b8hyyr	2921	6	~	~	NN
cord-006860-a3b8hyyr	2921	7	en	en	XX
cord-006860-a3b8hyyr	2921	8	;	;	:
cord-006860-a3b8hyyr	2921	9	Immuno	Immuno	NNP
cord-006860-a3b8hyyr	2921	10	-	-	HYPH
cord-006860-a3b8hyyr	2921	11	Ag	Ag	NNP
cord-006860-a3b8hyyr	2921	12	,	,	,
cord-006860-a3b8hyyr	2921	13	Wien	Wien	NNP
cord-006860-a3b8hyyr	2921	14	;	;	:
cord-006860-a3b8hyyr	2921	15	Klinikum	Klinikum	NNP
cord-006860-a3b8hyyr	2921	16	der	der	NNP
cord-006860-a3b8hyyr	2921	17	J.W.	J.W.	NNP
cord-006860-a3b8hyyr	2921	18	Goethe	Goethe	NNP
cord-006860-a3b8hyyr	2921	19	-	-	HYPH
cord-006860-a3b8hyyr	2921	20	Univ	Univ	NNP
cord-006860-a3b8hyyr	2921	21	.	.	.
cord-006860-a3b8hyyr	2922	1	Frankfurt	Frankfurt	NNP
cord-006860-a3b8hyyr	2922	2	am	be	VBP
cord-006860-a3b8hyyr	2922	3	Main	Main	NNP
cord-006860-a3b8hyyr	2922	4	,	,	,
cord-006860-a3b8hyyr	2922	5	Abt	Abt	NNP
cord-006860-a3b8hyyr	2922	6	.	.	.
cord-006860-a3b8hyyr	2922	7	f.	f.	NNP
cord-006860-a3b8hyyr	2922	8	Angiologie	Angiologie	NNP
cord-006860-a3b8hyyr	2922	9	.	.	.
cord-006860-a3b8hyyr	2923	1	Factor	factor	NN
cord-006860-a3b8hyyr	2923	2	X	X	NNP
cord-006860-a3b8hyyr	2923	3	(	(	-LRB-
cord-006860-a3b8hyyr	2923	4	FX	FX	NNP
cord-006860-a3b8hyyr	2923	5	)	)	-RRB-
cord-006860-a3b8hyyr	2923	6	is	be	VBZ
cord-006860-a3b8hyyr	2923	7	a	a	DT
cord-006860-a3b8hyyr	2923	8	Vitamin	vitamin	NN
cord-006860-a3b8hyyr	2923	9	K	k	NN
cord-006860-a3b8hyyr	2923	10	-	-	HYPH
cord-006860-a3b8hyyr	2923	11	dependent	dependent	JJ
cord-006860-a3b8hyyr	2923	12	plasma	plasma	NN
cord-006860-a3b8hyyr	2923	13	protein	protein	NN
cord-006860-a3b8hyyr	2923	14	which	which	WDT
cord-006860-a3b8hyyr	2923	15	is	be	VBZ
cord-006860-a3b8hyyr	2923	16	activated	activate	VBN
cord-006860-a3b8hyyr	2923	17	either	either	CC
cord-006860-a3b8hyyr	2923	18	by	by	IN
cord-006860-a3b8hyyr	2923	19	FVIla	fvila	NN
cord-006860-a3b8hyyr	2923	20	/	/	SYM
cord-006860-a3b8hyyr	2923	21	tissue	tissue	NN
cord-006860-a3b8hyyr	2923	22	factor	factor	NN
cord-006860-a3b8hyyr	2923	23	or	or	CC
cord-006860-a3b8hyyr	2923	24	IXaNIIla	IXaNIIla	NNP
cord-006860-a3b8hyyr	2923	25	.	.	.
cord-006860-a3b8hyyr	2924	1	FXa	FXa	NNP
cord-006860-a3b8hyyr	2924	2	is	be	VBZ
cord-006860-a3b8hyyr	2924	3	the	the	DT
cord-006860-a3b8hyyr	2924	4	main	main	JJ
cord-006860-a3b8hyyr	2924	5	enzyme	enzyme	NN
cord-006860-a3b8hyyr	2924	6	for	for	IN
cord-006860-a3b8hyyr	2924	7	conversion	conversion	NN
cord-006860-a3b8hyyr	2924	8	of	of	IN
cord-006860-a3b8hyyr	2924	9	prothrembin	prothrembin	NNP
cord-006860-a3b8hyyr	2924	10	to	to	IN
cord-006860-a3b8hyyr	2924	11	thrombin	thrombin	NN
cord-006860-a3b8hyyr	2924	12	.	.	.
cord-006860-a3b8hyyr	2925	1	The	the	DT
cord-006860-a3b8hyyr	2925	2	congenital	congenital	JJ
cord-006860-a3b8hyyr	2925	3	F×-deficiency	f×-deficiency	NN
cord-006860-a3b8hyyr	2926	1	(	(	-LRB-
cord-006860-a3b8hyyr	2926	2	Stuart	Stuart	NNP
cord-006860-a3b8hyyr	2926	3	-Prower	-prower	NN
cord-006860-a3b8hyyr	2926	4	-	-	HYPH
cord-006860-a3b8hyyr	2926	5	defect	defect	NN
cord-006860-a3b8hyyr	2926	6	)	)	-RRB-
cord-006860-a3b8hyyr	2926	7	being	be	VBG
cord-006860-a3b8hyyr	2926	8	inherited	inherit	VBN
cord-006860-a3b8hyyr	2926	9	as	as	IN
cord-006860-a3b8hyyr	2926	10	an	an	DT
cord-006860-a3b8hyyr	2926	11	autosomal	autosomal	JJ
cord-006860-a3b8hyyr	2926	12	recessive	recessive	JJ
cord-006860-a3b8hyyr	2926	13	trait	trait	NN
cord-006860-a3b8hyyr	2926	14	subsequently	subsequently	RB
cord-006860-a3b8hyyr	2926	15	leads	lead	VBZ
cord-006860-a3b8hyyr	2926	16	to	to	IN
cord-006860-a3b8hyyr	2926	17	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2926	18	diasthesis	diasthesis	NN
cord-006860-a3b8hyyr	2926	19	of	of	IN
cord-006860-a3b8hyyr	2926	20	varying	vary	VBG
cord-006860-a3b8hyyr	2926	21	severity	severity	NN
cord-006860-a3b8hyyr	2926	22	.	.	.
cord-006860-a3b8hyyr	2927	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	2927	2	propositus	propositus	NN
cord-006860-a3b8hyyr	2927	3	is	be	VBZ
cord-006860-a3b8hyyr	2927	4	a	a	DT
cord-006860-a3b8hyyr	2927	5	24	24	CD
cord-006860-a3b8hyyr	2927	6	year	year	NN
cord-006860-a3b8hyyr	2927	7	old	old	JJ
cord-006860-a3b8hyyr	2927	8	patient	patient	NN
cord-006860-a3b8hyyr	2927	9	presenting	present	VBG
cord-006860-a3b8hyyr	2927	10	a	a	DT
cord-006860-a3b8hyyr	2927	11	mild	mild	JJ
cord-006860-a3b8hyyr	2927	12	bleeding	bleeding	NN
cord-006860-a3b8hyyr	2927	13	tendency	tendency	NN
cord-006860-a3b8hyyr	2927	14	.	.	.
cord-006860-a3b8hyyr	2928	1	His	-PRON-	PRP$
cord-006860-a3b8hyyr	2928	2	PTT	ptt	NN
cord-006860-a3b8hyyr	2928	3	(	(	-LRB-
cord-006860-a3b8hyyr	2928	4	36	36	CD
cord-006860-a3b8hyyr	2928	5	sec	sec	NNP
cord-006860-a3b8hyyr	2928	6	)	)	-RRB-
cord-006860-a3b8hyyr	2928	7	is	be	VBZ
cord-006860-a3b8hyyr	2928	8	within	within	IN
cord-006860-a3b8hyyr	2928	9	the	the	DT
cord-006860-a3b8hyyr	2928	10	normal	normal	JJ
cord-006860-a3b8hyyr	2928	11	range	range	NN
cord-006860-a3b8hyyr	2928	12	,	,	,
cord-006860-a3b8hyyr	2928	13	the	the	DT
cord-006860-a3b8hyyr	2928	14	PT	pt	NN
cord-006860-a3b8hyyr	2928	15	(	(	-LRB-
cord-006860-a3b8hyyr	2928	16	73	73	CD
cord-006860-a3b8hyyr	2928	17	%	%	NN
cord-006860-a3b8hyyr	2928	18	of	of	IN
cord-006860-a3b8hyyr	2928	19	normal	normal	JJ
cord-006860-a3b8hyyr	2928	20	)	)	-RRB-
cord-006860-a3b8hyyr	2928	21	is	be	VBZ
cord-006860-a3b8hyyr	2928	22	slightly	slightly	RB
cord-006860-a3b8hyyr	2928	23	reduced	reduce	VBN
cord-006860-a3b8hyyr	2928	24	.	.	.
cord-006860-a3b8hyyr	2929	1	The	the	DT
cord-006860-a3b8hyyr	2929	2	Factor	Factor	NNP
cord-006860-a3b8hyyr	2929	3	X	x	NN
cord-006860-a3b8hyyr	2929	4	antigen	antigen	NN
cord-006860-a3b8hyyr	2929	5	level	level	NN
cord-006860-a3b8hyyr	2929	6	is	be	VBZ
cord-006860-a3b8hyyr	2929	7	reduced	reduce	VBN
cord-006860-a3b8hyyr	2929	8	to	to	IN
cord-006860-a3b8hyyr	2929	9	55	55	CD
cord-006860-a3b8hyyr	2929	10	%	%	NN
cord-006860-a3b8hyyr	2929	11	of	of	IN
cord-006860-a3b8hyyr	2929	12	normal	normal	JJ
cord-006860-a3b8hyyr	2929	13	.	.	.
cord-006860-a3b8hyyr	2930	1	Molecular	molecular	JJ
cord-006860-a3b8hyyr	2930	2	characterisaUon	characterisaUon	NNS
cord-006860-a3b8hyyr	2930	3	of	of	IN
cord-006860-a3b8hyyr	2930	4	the	the	DT
cord-006860-a3b8hyyr	2930	5	genetic	genetic	JJ
cord-006860-a3b8hyyr	2930	6	defect	defect	NN
cord-006860-a3b8hyyr	2930	7	was	be	VBD
cord-006860-a3b8hyyr	2930	8	performed	perform	VBN
cord-006860-a3b8hyyr	2930	9	by	by	IN
cord-006860-a3b8hyyr	2930	10	amplification	amplification	NN
cord-006860-a3b8hyyr	2930	11	of	of	IN
cord-006860-a3b8hyyr	2930	12	the	the	DT
cord-006860-a3b8hyyr	2930	13	eight	eight	CD
cord-006860-a3b8hyyr	2930	14	exons	exon	NNS
cord-006860-a3b8hyyr	2930	15	and	and	CC
cord-006860-a3b8hyyr	2930	16	exonintron	exonintron	NNP
cord-006860-a3b8hyyr	2930	17	junctions	junction	NNS
cord-006860-a3b8hyyr	2930	18	by	by	IN
cord-006860-a3b8hyyr	2930	19	PCR	PCR	NNP
cord-006860-a3b8hyyr	2930	20	and	and	CC
cord-006860-a3b8hyyr	2930	21	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	2930	22	direct	direct	JJ
cord-006860-a3b8hyyr	2930	23	sequencing	sequencing	NN
cord-006860-a3b8hyyr	2930	24	of	of	IN
cord-006860-a3b8hyyr	2930	25	the	the	DT
cord-006860-a3b8hyyr	2930	26	products	product	NNS
cord-006860-a3b8hyyr	2930	27	.	.	.
cord-006860-a3b8hyyr	2931	1	In	in	IN
cord-006860-a3b8hyyr	2931	2	comparison	comparison	NN
cord-006860-a3b8hyyr	2931	3	to	to	IN
cord-006860-a3b8hyyr	2931	4	the	the	DT
cord-006860-a3b8hyyr	2931	5	normal	normal	JJ
cord-006860-a3b8hyyr	2931	6	sequence	sequence	NN
cord-006860-a3b8hyyr	2931	7	we	-PRON-	PRP
cord-006860-a3b8hyyr	2931	8	could	could	MD
cord-006860-a3b8hyyr	2931	9	determine	determine	VB
cord-006860-a3b8hyyr	2931	10	a	a	DT
cord-006860-a3b8hyyr	2931	11	single	single	JJ
cord-006860-a3b8hyyr	2931	12	mismatch	mismatch	NN
cord-006860-a3b8hyyr	2931	13	within	within	IN
cord-006860-a3b8hyyr	2931	14	exon	exon	NN
cord-006860-a3b8hyyr	2931	15	II	II	NNP
cord-006860-a3b8hyyr	2931	16	resulting	result	VBG
cord-006860-a3b8hyyr	2931	17	in	in	IN
cord-006860-a3b8hyyr	2931	18	the	the	DT
cord-006860-a3b8hyyr	2931	19	substitution	substitution	NN
cord-006860-a3b8hyyr	2931	20	of	of	IN
cord-006860-a3b8hyyr	2931	21	+25	+25	NNP
cord-006860-a3b8hyyr	2931	22	Gla	Gla	NNP
cord-006860-a3b8hyyr	2931	23	(	(	-LRB-
cord-006860-a3b8hyyr	2931	24	GAA	GAA	NNP
cord-006860-a3b8hyyr	2931	25	)	)	-RRB-
cord-006860-a3b8hyyr	2931	26	by	by	IN
cord-006860-a3b8hyyr	2931	27	Lys	Lys	NNP
cord-006860-a3b8hyyr	2931	28	(	(	-LRB-
cord-006860-a3b8hyyr	2931	29	AAA	AAA	NNP
cord-006860-a3b8hyyr	2931	30	)	)	-RRB-
cord-006860-a3b8hyyr	2931	31	.	.	.
cord-006860-a3b8hyyr	2932	1	The	the	DT
cord-006860-a3b8hyyr	2932	2	mutation	mutation	NN
cord-006860-a3b8hyyr	2932	3	abolishes	abolish	VBZ
cord-006860-a3b8hyyr	2932	4	a	a	DT
cord-006860-a3b8hyyr	2932	5	naturally	naturally	RB
cord-006860-a3b8hyyr	2932	6	occuring	occur	VBG
cord-006860-a3b8hyyr	2932	7	Mboti	Mboti	NNP
cord-006860-a3b8hyyr	2932	8	site	site	NN
cord-006860-a3b8hyyr	2932	9	in	in	IN
cord-006860-a3b8hyyr	2932	10	the	the	DT
cord-006860-a3b8hyyr	2932	11	DNA	dna	NN
cord-006860-a3b8hyyr	2932	12	sequence	sequence	NN
cord-006860-a3b8hyyr	2932	13	of	of	IN
cord-006860-a3b8hyyr	2932	14	exon	exon	NN
cord-006860-a3b8hyyr	2932	15	II	II	NNP
cord-006860-a3b8hyyr	2932	16	.	.	.
cord-006860-a3b8hyyr	2933	1	The	the	DT
cord-006860-a3b8hyyr	2933	2	status	status	NN
cord-006860-a3b8hyyr	2933	3	of	of	IN
cord-006860-a3b8hyyr	2933	4	the	the	DT
cord-006860-a3b8hyyr	2933	5	FX	FX	NNP
cord-006860-a3b8hyyr	2933	6	encoding	encoding	NN
cord-006860-a3b8hyyr	2933	7	alleles	allele	NNS
cord-006860-a3b8hyyr	2933	8	was	be	VBD
cord-006860-a3b8hyyr	2933	9	determined	determine	VBN
cord-006860-a3b8hyyr	2933	10	in	in	IN
cord-006860-a3b8hyyr	2933	11	the	the	DT
cord-006860-a3b8hyyr	2933	12	propositus	propositus	NN
cord-006860-a3b8hyyr	2933	13	,	,	,
cord-006860-a3b8hyyr	2933	14	his	-PRON-	PRP$
cord-006860-a3b8hyyr	2933	15	mother	mother	NN
cord-006860-a3b8hyyr	2933	16	and	and	CC
cord-006860-a3b8hyyr	2933	17	one	one	CD
cord-006860-a3b8hyyr	2933	18	of	of	IN
cord-006860-a3b8hyyr	2933	19	his	-PRON-	PRP$
cord-006860-a3b8hyyr	2933	20	brothers	brother	NNS
cord-006860-a3b8hyyr	2933	21	by	by	IN
cord-006860-a3b8hyyr	2933	22	amplification	amplification	NN
cord-006860-a3b8hyyr	2933	23	of	of	IN
cord-006860-a3b8hyyr	2933	24	exon	exon	NN
cord-006860-a3b8hyyr	2933	25	II	II	NNP
cord-006860-a3b8hyyr	2933	26	and	and	CC
cord-006860-a3b8hyyr	2933	27	restriction	restriction	NN
cord-006860-a3b8hyyr	2933	28	digest	digest	NN
cord-006860-a3b8hyyr	2933	29	with	with	IN
cord-006860-a3b8hyyr	2933	30	Mboll	Mboll	NNP
cord-006860-a3b8hyyr	2933	31	.	.	.
cord-006860-a3b8hyyr	2934	1	These	these	DT
cord-006860-a3b8hyyr	2934	2	family	family	NN
cord-006860-a3b8hyyr	2934	3	members	member	NNS
cord-006860-a3b8hyyr	2934	4	were	be	VBD
cord-006860-a3b8hyyr	2934	5	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	2934	6	with	with	IN
cord-006860-a3b8hyyr	2934	7	respect	respect	NN
cord-006860-a3b8hyyr	2934	8	to	to	IN
cord-006860-a3b8hyyr	2934	9	the	the	DT
cord-006860-a3b8hyyr	2934	10	mutation	mutation	NN
cord-006860-a3b8hyyr	2934	11	in	in	IN
cord-006860-a3b8hyyr	2934	12	exon	exon	NN
cord-006860-a3b8hyyr	2934	13	I1	i1	NN
cord-006860-a3b8hyyr	2934	14	.	.	.
cord-006860-a3b8hyyr	2935	1	FX	FX	NNP
cord-006860-a3b8hyyr	2935	2	was	be	VBD
cord-006860-a3b8hyyr	2935	3	isolated	isolate	VBN
cord-006860-a3b8hyyr	2935	4	from	from	IN
cord-006860-a3b8hyyr	2935	5	plasma	plasma	NN
cord-006860-a3b8hyyr	2935	6	of	of	IN
cord-006860-a3b8hyyr	2935	7	the	the	DT
cord-006860-a3b8hyyr	2935	8	propositus	propositus	NNP
cord-006860-a3b8hyyr	2935	9	by	by	IN
cord-006860-a3b8hyyr	2935	10	monoq	monoq	NNP
cord-006860-a3b8hyyr	2935	11	ion	ion	NNP
cord-006860-a3b8hyyr	2935	12	exchange	exchange	NN
cord-006860-a3b8hyyr	2935	13	chromatogrephy	chromatogrephy	NN
cord-006860-a3b8hyyr	2935	14	.	.	.
cord-006860-a3b8hyyr	2936	1	Performing	perform	VBG
cord-006860-a3b8hyyr	2936	2	clotting	clotting	NN
cord-006860-a3b8hyyr	2936	3	assays	assay	NNS
cord-006860-a3b8hyyr	2936	4	with	with	IN
cord-006860-a3b8hyyr	2936	5	purified	purify	VBN
cord-006860-a3b8hyyr	2936	6	FX	FX	NNP
cord-006860-a3b8hyyr	2936	7	Frankfurt	Frankfurt	NNP
cord-006860-a3b8hyyr	2937	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	2937	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	2937	3	determined	determine	VBD
cord-006860-a3b8hyyr	2937	4	an	an	DT
cord-006860-a3b8hyyr	2937	5	activity	activity	NN
cord-006860-a3b8hyyr	2937	6	of	of	IN
cord-006860-a3b8hyyr	2937	7	89	89	CD
cord-006860-a3b8hyyr	2937	8	%	%	NN
cord-006860-a3b8hyyr	2937	9	of	of	IN
cord-006860-a3b8hyyr	2937	10	normal	normal	JJ
cord-006860-a3b8hyyr	2937	11	FX	FX	NNP
cord-006860-a3b8hyyr	2937	12	upon	upon	IN
cord-006860-a3b8hyyr	2937	13	activation	activation	NN
cord-006860-a3b8hyyr	2937	14	with	with	IN
cord-006860-a3b8hyyr	2937	15	RW	RW	NNP
cord-006860-a3b8hyyr	2937	16	,	,	,
cord-006860-a3b8hyyr	2937	17	77	77	CD
cord-006860-a3b8hyyr	2937	18	%	%	NN
cord-006860-a3b8hyyr	2937	19	upon	upon	IN
cord-006860-a3b8hyyr	2937	20	intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	2937	21	activation	activation	NN
cord-006860-a3b8hyyr	2937	22	(	(	-LRB-
cord-006860-a3b8hyyr	2937	23	aPTT	aptt	NN
cord-006860-a3b8hyyr	2937	24	)	)	-RRB-
cord-006860-a3b8hyyr	2937	25	and	and	CC
cord-006860-a3b8hyyr	2937	26	81	81	CD
cord-006860-a3b8hyyr	2937	27	%	%	NN
cord-006860-a3b8hyyr	2937	28	upon	upon	IN
cord-006860-a3b8hyyr	2937	29	extrinsic	extrinsic	JJ
cord-006860-a3b8hyyr	2937	30	activation	activation	NN
cord-006860-a3b8hyyr	2937	31	(	(	-LRB-
cord-006860-a3b8hyyr	2937	32	PT	pt	NN
cord-006860-a3b8hyyr	2937	33	)	)	-RRB-
cord-006860-a3b8hyyr	2937	34	.	.	.
cord-006860-a3b8hyyr	2938	1	This	this	DT
cord-006860-a3b8hyyr	2938	2	compares	compare	VBZ
cord-006860-a3b8hyyr	2938	3	well	well	RB
cord-006860-a3b8hyyr	2938	4	with	with	IN
cord-006860-a3b8hyyr	2938	5	the	the	DT
cord-006860-a3b8hyyr	2938	6	results	result	NNS
cord-006860-a3b8hyyr	2938	7	obtained	obtain	VBN
cord-006860-a3b8hyyr	2938	8	from	from	IN
cord-006860-a3b8hyyr	2938	9	the	the	DT
cord-006860-a3b8hyyr	2938	10	patient	patient	NN
cord-006860-a3b8hyyr	2938	11	plasma	plasma	NN
cord-006860-a3b8hyyr	2938	12	(	(	-LRB-
cord-006860-a3b8hyyr	2938	13	PT	PT	NNP
cord-006860-a3b8hyyr	2938	14	56	56	CD
cord-006860-a3b8hyyr	2938	15	%	%	NN
cord-006860-a3b8hyyr	2938	16	,	,	,
cord-006860-a3b8hyyr	2938	17	PTT	PTT	NNP
cord-006860-a3b8hyyr	2938	18	55	55	CD
cord-006860-a3b8hyyr	2938	19	%	%	NN
cord-006860-a3b8hyyr	2938	20	and	and	CC
cord-006860-a3b8hyyr	2938	21	RW	RW	NNP
cord-006860-a3b8hyyr	2938	22	57	57	CD
cord-006860-a3b8hyyr	2938	23	%	%	NN
cord-006860-a3b8hyyr	2938	24	of	of	IN
cord-006860-a3b8hyyr	2938	25	normal	normal	JJ
cord-006860-a3b8hyyr	2938	26	)	)	-RRB-
cord-006860-a3b8hyyr	2938	27	when	when	WRB
cord-006860-a3b8hyyr	2938	28	the	the	DT
cord-006860-a3b8hyyr	2938	29	reduced	reduce	VBN
cord-006860-a3b8hyyr	2938	30	FX	FX	NNP
cord-006860-a3b8hyyr	2938	31	-	-	HYPH
cord-006860-a3b8hyyr	2938	32	Ag	Ag	NNP
cord-006860-a3b8hyyr	2938	33	-	-	HYPH
cord-006860-a3b8hyyr	2938	34	level	level	NN
cord-006860-a3b8hyyr	2938	35	of	of	IN
cord-006860-a3b8hyyr	2938	36	the	the	DT
cord-006860-a3b8hyyr	2938	37	plasma	plasma	NN
cord-006860-a3b8hyyr	2938	38	(	(	-LRB-
cord-006860-a3b8hyyr	2938	39	55	55	CD
cord-006860-a3b8hyyr	2938	40	%	%	NN
cord-006860-a3b8hyyr	2938	41	)	)	-RRB-
cord-006860-a3b8hyyr	2938	42	is	be	VBZ
cord-006860-a3b8hyyr	2938	43	taken	take	VBN
cord-006860-a3b8hyyr	2938	44	into	into	IN
cord-006860-a3b8hyyr	2938	45	account	account	NN
cord-006860-a3b8hyyr	2938	46	_	_	NN
cord-006860-a3b8hyyr	2939	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	2939	2	therefore	therefore	RB
cord-006860-a3b8hyyr	2939	3	conclude	conclude	VBP
cord-006860-a3b8hyyr	2939	4	that	that	IN
cord-006860-a3b8hyyr	2939	5	the	the	DT
cord-006860-a3b8hyyr	2939	6	substitution	substitution	NN
cord-006860-a3b8hyyr	2939	7	of	of	IN
cord-006860-a3b8hyyr	2939	8	Gla	Gla	NNP
cord-006860-a3b8hyyr	2939	9	+25	+25	NNP
cord-006860-a3b8hyyr	2939	10	to	to	IN
cord-006860-a3b8hyyr	2939	11	Lys	Lys	NNP
cord-006860-a3b8hyyr	2939	12	results	result	NNS
cord-006860-a3b8hyyr	2939	13	in	in	IN
cord-006860-a3b8hyyr	2939	14	a	a	DT
cord-006860-a3b8hyyr	2939	15	FX	FX	NNP
cord-006860-a3b8hyyr	2939	16	molecule	molecule	NN
cord-006860-a3b8hyyr	2939	17	which	which	WDT
cord-006860-a3b8hyyr	2939	18	is	be	VBZ
cord-006860-a3b8hyyr	2939	19	severely	severely	RB
cord-006860-a3b8hyyr	2939	20	defective	defective	JJ
cord-006860-a3b8hyyr	2939	21	iP	ip	NN
cord-006860-a3b8hyyr	2939	22	both	both	CC
cord-006860-a3b8hyyr	2939	23	the	the	DT
cord-006860-a3b8hyyr	2939	24	intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	2939	25	and	and	CC
cord-006860-a3b8hyyr	2939	26	extrinsic	extrinsic	JJ
cord-006860-a3b8hyyr	2939	27	pathway	pathway	NN
cord-006860-a3b8hyyr	2939	28	of	of	IN
cord-006860-a3b8hyyr	2939	29	blood	blood	NN
cord-006860-a3b8hyyr	2939	30	coagulation	coagulation	NN
cord-006860-a3b8hyyr	2939	31	.	.	.
cord-006860-a3b8hyyr	2940	1	Bleeding	bleed	VBG
cord-006860-a3b8hyyr	2940	2	after	after	IN
cord-006860-a3b8hyyr	2940	3	cardioth~)racic	cardioth~)racic	JJ
cord-006860-a3b8hyyr	2940	4	surgery	surgery	NN
cord-006860-a3b8hyyr	2940	5	is	be	VBZ
cord-006860-a3b8hyyr	2940	6	still	still	RB
cord-006860-a3b8hyyr	2940	7	a	a	DT
cord-006860-a3b8hyyr	2940	8	frequent	frequent	JJ
cord-006860-a3b8hyyr	2940	9	,	,	,
cord-006860-a3b8hyyr	2940	10	important	important	JJ
cord-006860-a3b8hyyr	2940	11	and	and	CC
cord-006860-a3b8hyyr	2940	12	sometimes	sometimes	RB
cord-006860-a3b8hyyr	2940	13	life	life	NN
cord-006860-a3b8hyyr	2940	14	-	-	HYPH
cord-006860-a3b8hyyr	2940	15	threatening	threaten	VBG
cord-006860-a3b8hyyr	2940	16	complication	complication	NN
cord-006860-a3b8hyyr	2940	17	.	.	.
cord-006860-a3b8hyyr	2941	1	Thus	thus	RB
cord-006860-a3b8hyyr	2941	2	,	,	,
cord-006860-a3b8hyyr	2941	3	the	the	DT
cord-006860-a3b8hyyr	2941	4	aim	aim	NN
cord-006860-a3b8hyyr	2941	5	of	of	IN
cord-006860-a3b8hyyr	2941	6	this	this	DT
cord-006860-a3b8hyyr	2941	7	study	study	NN
cord-006860-a3b8hyyr	2941	8	was	be	VBD
cord-006860-a3b8hyyr	2941	9	to	to	TO
cord-006860-a3b8hyyr	2941	10	examine	examine	VB
cord-006860-a3b8hyyr	2941	11	routine	routine	JJ
cord-006860-a3b8hyyr	2941	12	parameters	parameter	NNS
cord-006860-a3b8hyyr	2941	13	of	of	IN
cord-006860-a3b8hyyr	2941	14	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	2941	15	and	and	CC
cord-006860-a3b8hyyr	2941	16	their	-PRON-	PRP$
cord-006860-a3b8hyyr	2941	17	predictive	predictive	JJ
cord-006860-a3b8hyyr	2941	18	values	value	NNS
cord-006860-a3b8hyyr	2941	19	for	for	IN
cord-006860-a3b8hyyr	2941	20	severe	severe	JJ
cord-006860-a3b8hyyr	2941	21	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	2941	22	.	.	.
cord-006860-a3b8hyyr	2942	1	This	this	DT
cord-006860-a3b8hyyr	2942	2	prospective	prospective	JJ
cord-006860-a3b8hyyr	2942	3	study	study	NN
cord-006860-a3b8hyyr	2942	4	included	include	VBD
cord-006860-a3b8hyyr	2942	5	patients	patient	NNS
cord-006860-a3b8hyyr	2942	6	undergoing	undergo	VBG
cord-006860-a3b8hyyr	2942	7	cardlopulmonary	cardlopulmonary	JJ
cord-006860-a3b8hyyr	2942	8	bypass	bypass	NN
cord-006860-a3b8hyyr	2942	9	surgery	surgery	NN
cord-006860-a3b8hyyr	2942	10	.	.	.
cord-006860-a3b8hyyr	2943	1	Blood	blood	NN
cord-006860-a3b8hyyr	2943	2	samples	sample	NNS
cord-006860-a3b8hyyr	2943	3	were	be	VBD
cord-006860-a3b8hyyr	2943	4	drawn	draw	VBN
cord-006860-a3b8hyyr	2943	5	preoperatively	preoperatively	RB
cord-006860-a3b8hyyr	2943	6	as	as	RB
cord-006860-a3b8hyyr	2943	7	well	well	RB
cord-006860-a3b8hyyr	2943	8	as	as	IN
cord-006860-a3b8hyyr	2943	9	0	0	CD
cord-006860-a3b8hyyr	2943	10	,	,	,
cord-006860-a3b8hyyr	2943	11	6	6	CD
cord-006860-a3b8hyyr	2943	12	,	,	,
cord-006860-a3b8hyyr	2943	13	18	18	CD
cord-006860-a3b8hyyr	2943	14	hours	hour	NNS
cord-006860-a3b8hyyr	2943	15	and	and	CC
cord-006860-a3b8hyyr	2943	16	2	2	CD
cord-006860-a3b8hyyr	2943	17	,	,	,
cord-006860-a3b8hyyr	2943	18	3	3	CD
cord-006860-a3b8hyyr	2943	19	,	,	,
cord-006860-a3b8hyyr	2943	20	4	4	CD
cord-006860-a3b8hyyr	2943	21	,	,	,
cord-006860-a3b8hyyr	2943	22	5	5	CD
cord-006860-a3b8hyyr	2943	23	,	,	,
cord-006860-a3b8hyyr	2943	24	6	6	CD
cord-006860-a3b8hyyr	2943	25	,	,	,
cord-006860-a3b8hyyr	2943	26	7	7	CD
cord-006860-a3b8hyyr	2943	27	,	,	,
cord-006860-a3b8hyyr	2943	28	8	8	CD
cord-006860-a3b8hyyr	2943	29	days	day	NNS
cord-006860-a3b8hyyr	2943	30	after	after	IN
cord-006860-a3b8hyyr	2943	31	surgery	surgery	NN
cord-006860-a3b8hyyr	2943	32	.	.	.
cord-006860-a3b8hyyr	2944	1	Blood	blood	NN
cord-006860-a3b8hyyr	2944	2	loss	loss	NN
cord-006860-a3b8hyyr	2944	3	from	from	IN
cord-006860-a3b8hyyr	2944	4	drains	drain	NNS
cord-006860-a3b8hyyr	2944	5	,	,	,
cord-006860-a3b8hyyr	2944	6	transfusion	transfusion	NN
cord-006860-a3b8hyyr	2944	7	of	of	IN
cord-006860-a3b8hyyr	2944	8	blood	blood	NN
cord-006860-a3b8hyyr	2944	9	products	product	NNS
cord-006860-a3b8hyyr	2944	10	and	and	CC
cord-006860-a3b8hyyr	2944	11	other	other	JJ
cord-006860-a3b8hyyr	2944	12	important	important	JJ
cord-006860-a3b8hyyr	2944	13	clinical	clinical	JJ
cord-006860-a3b8hyyr	2944	14	data	datum	NNS
cord-006860-a3b8hyyr	2944	15	were	be	VBD
cord-006860-a3b8hyyr	2944	16	monitored	monitor	VBN
cord-006860-a3b8hyyr	2944	17	apart	apart	RB
cord-006860-a3b8hyyr	2944	18	from	from	IN
cord-006860-a3b8hyyr	2944	19	platelet	platelet	NN
cord-006860-a3b8hyyr	2944	20	count	count	NN
cord-006860-a3b8hyyr	2944	21	,	,	,
cord-006860-a3b8hyyr	2944	22	hematocrit	hematocrit	NN
cord-006860-a3b8hyyr	2944	23	,	,	,
cord-006860-a3b8hyyr	2944	24	throm	throm	NNP
cord-006860-a3b8hyyr	2944	25	.	.	.
cord-006860-a3b8hyyr	2945	1	bin	bin	NNP
cord-006860-a3b8hyyr	2945	2	time	time	NNP
cord-006860-a3b8hyyr	2945	3	,	,	,
cord-006860-a3b8hyyr	2945	4	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	2945	5	time	time	NN
cord-006860-a3b8hyyr	2945	6	,	,	,
cord-006860-a3b8hyyr	2945	7	aPTT	aptt	NN
cord-006860-a3b8hyyr	2945	8	and	and	CC
cord-006860-a3b8hyyr	2945	9	levels	level	NNS
cord-006860-a3b8hyyr	2945	10	of	of	IN
cord-006860-a3b8hyyr	2945	11	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	2945	12	,	,	,
cord-006860-a3b8hyyr	2945	13	ATIII	ATIII	NNP
cord-006860-a3b8hyyr	2945	14	and	and	CC
cord-006860-a3b8hyyr	2945	15	C	C	NNP
cord-006860-a3b8hyyr	2945	16	-	-	HYPH
cord-006860-a3b8hyyr	2945	17	reactive	reactive	JJ
cord-006860-a3b8hyyr	2945	18	protein	protein	NN
cord-006860-a3b8hyyr	2945	19	;	;	:
cord-006860-a3b8hyyr	2945	20	soluble	soluble	JJ
cord-006860-a3b8hyyr	2945	21	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2945	22	(	(	-LRB-
cord-006860-a3b8hyyr	2945	23	SF	SF	NNP
cord-006860-a3b8hyyr	2945	24	)	)	-RRB-
cord-006860-a3b8hyyr	2945	25	was	be	VBD
cord-006860-a3b8hyyr	2945	26	measured	measure	VBN
cord-006860-a3b8hyyr	2945	27	via	via	IN
cord-006860-a3b8hyyr	2945	28	protamine	protamine	NN
cord-006860-a3b8hyyr	2945	29	sulfate	sulfate	NN
cord-006860-a3b8hyyr	2945	30	aggregability	aggregability	NN
cord-006860-a3b8hyyr	2945	31	and	and	CC
cord-006860-a3b8hyyr	2945	32	total	total	NN
cord-006860-a3b8hyyr	2945	33	fibrin(ogen	fibrin(ogen	NN
cord-006860-a3b8hyyr	2945	34	)	)	-RRB-
cord-006860-a3b8hyyr	2945	35	degradation	degradation	NN
cord-006860-a3b8hyyr	2945	36	products	product	NNS
cord-006860-a3b8hyyr	2945	37	(	(	-LRB-
cord-006860-a3b8hyyr	2945	38	FtDP	FtDP	NNP
cord-006860-a3b8hyyr	2945	39	)	)	-RRB-
cord-006860-a3b8hyyr	2945	40	by	by	IN
cord-006860-a3b8hyyr	2945	41	an	an	DT
cord-006860-a3b8hyyr	2945	42	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	2945	43	from	from	IN
cord-006860-a3b8hyyr	2945	44	Organon	Organon	NNP
cord-006860-a3b8hyyr	2945	45	Teknika	Teknika	NNP
cord-006860-a3b8hyyr	2945	46	.	.	.
cord-006860-a3b8hyyr	2946	1	N=	n=	CD
cord-006860-a3b8hyyr	2946	2	109	109	CD
cord-006860-a3b8hyyr	2946	3	patients	patient	NNS
cord-006860-a3b8hyyr	2946	4	were	be	VBD
cord-006860-a3b8hyyr	2946	5	examined	examine	VBN
cord-006860-a3b8hyyr	2946	6	(	(	-LRB-
cord-006860-a3b8hyyr	2946	7	age	age	NN
cord-006860-a3b8hyyr	2946	8	:	:	:
cord-006860-a3b8hyyr	2946	9	64	64	CD
cord-006860-a3b8hyyr	2946	10	+	+	SYM
cord-006860-a3b8hyyr	2946	11	9	9	CD
cord-006860-a3b8hyyr	2946	12	y	y	NN
cord-006860-a3b8hyyr	2946	13	)	)	-RRB-
cord-006860-a3b8hyyr	2946	14	.	.	.
cord-006860-a3b8hyyr	2947	1	They	-PRON-	PRP
cord-006860-a3b8hyyr	2947	2	lost	lose	VBD
cord-006860-a3b8hyyr	2947	3	750+__460	750+__460	CD
cord-006860-a3b8hyyr	2947	4	ml	ml	NN
cord-006860-a3b8hyyr	2947	5	blood	blood	NN
cord-006860-a3b8hyyr	2947	6	(	(	-LRB-
cord-006860-a3b8hyyr	2947	7	mean_+SD	mean_+SD	NNP
cord-006860-a3b8hyyr	2947	8	)	)	-RRB-
cord-006860-a3b8hyyr	2947	9	into	into	IN
cord-006860-a3b8hyyr	2947	10	the	the	DT
cord-006860-a3b8hyyr	2947	11	drains	drain	NNS
cord-006860-a3b8hyyr	2947	12	within	within	IN
cord-006860-a3b8hyyr	2947	13	the	the	DT
cord-006860-a3b8hyyr	2947	14	first	first	JJ
cord-006860-a3b8hyyr	2947	15	18	18	CD
cord-006860-a3b8hyyr	2947	16	hours	hour	NNS
cord-006860-a3b8hyyr	2947	17	after	after	IN
cord-006860-a3b8hyyr	2947	18	end	end	NN
cord-006860-a3b8hyyr	2947	19	of	of	IN
cord-006860-a3b8hyyr	2947	20	sur	sur	NN
cord-006860-a3b8hyyr	2947	21	.	.	.
cord-006860-a3b8hyyr	2948	1	gory	gory	JJ
cord-006860-a3b8hyyr	2948	2	.	.	.
cord-006860-a3b8hyyr	2949	1	A	a	DT
cord-006860-a3b8hyyr	2949	2	severe	severe	JJ
cord-006860-a3b8hyyr	2949	3	bleeding	bleeding	NN
cord-006860-a3b8hyyr	2949	4	was	be	VBD
cord-006860-a3b8hyyr	2949	5	defined	define	VBN
cord-006860-a3b8hyyr	2949	6	to	to	TO
cord-006860-a3b8hyyr	2949	7	exist	exist	VB
cord-006860-a3b8hyyr	2949	8	,	,	,
cord-006860-a3b8hyyr	2949	9	if	if	IN
cord-006860-a3b8hyyr	2949	10	the	the	DT
cord-006860-a3b8hyyr	2949	11	blood	blood	NN
cord-006860-a3b8hyyr	2949	12	loss	loss	NN
cord-006860-a3b8hyyr	2949	13	exceeded	exceed	VBD
cord-006860-a3b8hyyr	2949	14	this	this	DT
cord-006860-a3b8hyyr	2949	15	range	range	NN
cord-006860-a3b8hyyr	2949	16	(	(	-LRB-
cord-006860-a3b8hyyr	2949	17	>	>	NFP
cord-006860-a3b8hyyr	2949	18	1200	1200	CD
cord-006860-a3b8hyyr	2949	19	ml	ml	XX
cord-006860-a3b8hyyr	2949	20	within	within	IN
cord-006860-a3b8hyyr	2949	21	18	18	CD
cord-006860-a3b8hyyr	2949	22	h	h	NN
cord-006860-a3b8hyyr	2949	23	)	)	-RRB-
cord-006860-a3b8hyyr	2949	24	.	.	.
cord-006860-a3b8hyyr	2950	1	Fibrin(ogen	Fibrin(ogen	NNP
cord-006860-a3b8hyyr	2950	2	)	)	-RRB-
cord-006860-a3b8hyyr	2950	3	split	split	NN
cord-006860-a3b8hyyr	2950	4	products	product	NNS
cord-006860-a3b8hyyr	2950	5	proved	prove	VBD
cord-006860-a3b8hyyr	2950	6	to	to	TO
cord-006860-a3b8hyyr	2950	7	be	be	VB
cord-006860-a3b8hyyr	2950	8	a	a	DT
cord-006860-a3b8hyyr	2950	9	useful	useful	JJ
cord-006860-a3b8hyyr	2950	10	parameter	parameter	NN
cord-006860-a3b8hyyr	2950	11	in	in	IN
cord-006860-a3b8hyyr	2950	12	predicting	predict	VBG
cord-006860-a3b8hyyr	2950	13	the	the	DT
cord-006860-a3b8hyyr	2950	14	risk	risk	NN
cord-006860-a3b8hyyr	2950	15	of	of	IN
cord-006860-a3b8hyyr	2950	16	severe	severe	JJ
cord-006860-a3b8hyyr	2950	17	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	2950	18	:	:	:
cord-006860-a3b8hyyr	2950	19	FtDP	FtDP	NNP
cord-006860-a3b8hyyr	2950	20	levels	level	NNS
cord-006860-a3b8hyyr	2950	21	exceeding	exceed	VBG
cord-006860-a3b8hyyr	2950	22	12	12	CD
cord-006860-a3b8hyyr	2950	23	mg	mg	NN
cord-006860-a3b8hyyr	2951	1	/I	/i	NN
cord-006860-a3b8hyyr	2951	2	at	at	IN
cord-006860-a3b8hyyr	2951	3	end	end	NN
cord-006860-a3b8hyyr	2951	4	of	of	IN
cord-006860-a3b8hyyr	2951	5	surgery	surgery	NN
cord-006860-a3b8hyyr	2952	1	(	(	-LRB-
cord-006860-a3b8hyyr	2952	2	n	n	NN
cord-006860-a3b8hyyr	2952	3	=	=	SYM
cord-006860-a3b8hyyr	2952	4	105	105	CD
cord-006860-a3b8hyyr	2952	5	)	)	-RRB-
cord-006860-a3b8hyyr	2952	6	had	have	VBD
cord-006860-a3b8hyyr	2952	7	a	a	DT
cord-006860-a3b8hyyr	2952	8	negative	negative	JJ
cord-006860-a3b8hyyr	2952	9	predictive	predictive	JJ
cord-006860-a3b8hyyr	2952	10	value	value	NN
cord-006860-a3b8hyyr	2952	11	of	of	IN
cord-006860-a3b8hyyr	2952	12	94	94	CD
cord-006860-a3b8hyyr	2952	13	%	%	NN
cord-006860-a3b8hyyr	2952	14	,	,	,
cord-006860-a3b8hyyr	2952	15	positive	positive	JJ
cord-006860-a3b8hyyr	2952	16	predictive	predictive	JJ
cord-006860-a3b8hyyr	2952	17	value	value	NN
cord-006860-a3b8hyyr	2952	18	of	of	IN
cord-006860-a3b8hyyr	2952	19	60	60	CD
cord-006860-a3b8hyyr	2952	20	%	%	NN
cord-006860-a3b8hyyr	2952	21	,	,	,
cord-006860-a3b8hyyr	2952	22	specificily	specificily	RB
cord-006860-a3b8hyyr	2952	23	of	of	IN
cord-006860-a3b8hyyr	2952	24	96	96	CD
cord-006860-a3b8hyyr	2952	25	%	%	NN
cord-006860-a3b8hyyr	2952	26	and	and	CC
cord-006860-a3b8hyyr	2952	27	a	a	DT
cord-006860-a3b8hyyr	2952	28	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	2952	29	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2952	30	of	of	IN
cord-006860-a3b8hyyr	2952	31	91	91	CD
cord-006860-a3b8hyyr	2952	32	%	%	NN
cord-006860-a3b8hyyr	2952	33	.	.	.
cord-006860-a3b8hyyr	2953	1	In	in	IN
cord-006860-a3b8hyyr	2953	2	contrast	contrast	NN
cord-006860-a3b8hyyr	2953	3	,	,	,
cord-006860-a3b8hyyr	2953	4	soluble	soluble	JJ
cord-006860-a3b8hyyr	2953	5	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2953	6	which	which	WDT
cord-006860-a3b8hyyr	2953	7	correlated	correlate	VBD
cord-006860-a3b8hyyr	2953	8	well	well	RB
cord-006860-a3b8hyyr	2953	9	with	with	IN
cord-006860-a3b8hyyr	2953	10	fibrinopeptide	fibrinopeptide	RB
cord-006860-a3b8hyyr	2953	11	A	a	NN
cord-006860-a3b8hyyr	2953	12	(	(	-LRB-
cord-006860-a3b8hyyr	2953	13	r>0.91	r>0.91	NNP
cord-006860-a3b8hyyr	2953	14	,	,	,
cord-006860-a3b8hyyr	2953	15	n=	n=	NNP
cord-006860-a3b8hyyr	2953	16	20	20	CD
cord-006860-a3b8hyyr	2953	17	)	)	-RRB-
cord-006860-a3b8hyyr	2953	18	did	do	VBD
cord-006860-a3b8hyyr	2953	19	not	not	RB
cord-006860-a3b8hyyr	2953	20	correlate	correlate	VB
cord-006860-a3b8hyyr	2953	21	neither	neither	CC
cord-006860-a3b8hyyr	2953	22	with	with	IN
cord-006860-a3b8hyyr	2953	23	degradation	degradation	NN
cord-006860-a3b8hyyr	2953	24	products	product	NNS
cord-006860-a3b8hyyr	2953	25	nor	nor	CC
cord-006860-a3b8hyyr	2953	26	with	with	IN
cord-006860-a3b8hyyr	2953	27	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2953	28	complications	complication	NNS
cord-006860-a3b8hyyr	2953	29	(	(	-LRB-
cord-006860-a3b8hyyr	2953	30	n=	n=	NNP
cord-006860-a3b8hyyr	2953	31	109	109	CD
cord-006860-a3b8hyyr	2953	32	)	)	-RRB-
cord-006860-a3b8hyyr	2953	33	.	.	.
cord-006860-a3b8hyyr	2954	1	This	this	DT
cord-006860-a3b8hyyr	2954	2	observation	observation	NN
cord-006860-a3b8hyyr	2954	3	does	do	VBZ
cord-006860-a3b8hyyr	2954	4	not	not	RB
cord-006860-a3b8hyyr	2954	5	match	match	VB
cord-006860-a3b8hyyr	2954	6	to	to	IN
cord-006860-a3b8hyyr	2954	7	the	the	DT
cord-006860-a3b8hyyr	2954	8	correspondence	correspondence	NN
cord-006860-a3b8hyyr	2954	9	of	of	IN
cord-006860-a3b8hyyr	2954	10	SF	SF	NNP
cord-006860-a3b8hyyr	2954	11	with	with	IN
cord-006860-a3b8hyyr	2954	12	organ	organ	NN
cord-006860-a3b8hyyr	2954	13	dysfunction	dysfunction	NN
cord-006860-a3b8hyyr	2954	14	during	during	IN
cord-006860-a3b8hyyr	2954	15	DIC	DIC	NNP
cord-006860-a3b8hyyr	2954	16	:	:	:
cord-006860-a3b8hyyr	2954	17	SF	SF	NNP
cord-006860-a3b8hyyr	2954	18	reached	reach	VBD
cord-006860-a3b8hyyr	2954	19	a	a	DT
cord-006860-a3b8hyyr	2954	20	neg.predictive	neg.predictive	NNP
cord-006860-a3b8hyyr	2954	21	value	value	NN
cord-006860-a3b8hyyr	2954	22	near	near	IN
cord-006860-a3b8hyyr	2954	23	95	95	CD
cord-006860-a3b8hyyr	2954	24	%	%	NN
cord-006860-a3b8hyyr	2954	25	and	and	CC
cord-006860-a3b8hyyr	2954	26	a	a	DT
cord-006860-a3b8hyyr	2954	27	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	2954	28	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2954	29	of	of	IN
cord-006860-a3b8hyyr	2954	30	>	>	$
cord-006860-a3b8hyyr	2954	31	70	70	CD
cord-006860-a3b8hyyr	2954	32	%	%	NN
cord-006860-a3b8hyyr	2954	33	(	(	-LRB-
cord-006860-a3b8hyyr	2954	34	pat	pat	NNP
cord-006860-a3b8hyyr	2954	35	.	.	.
cord-006860-a3b8hyyr	2955	1	without	without	IN
cord-006860-a3b8hyyr	2955	2	antifibrinolytic	antifibrinolytic	JJ
cord-006860-a3b8hyyr	2955	3	drugs	drug	NNS
cord-006860-a3b8hyyr	2955	4	)	)	-RRB-
cord-006860-a3b8hyyr	2955	5	,	,	,
cord-006860-a3b8hyyr	2955	6	which	which	WDT
cord-006860-a3b8hyyr	2955	7	complies	comply	VBZ
cord-006860-a3b8hyyr	2955	8	to	to	IN
cord-006860-a3b8hyyr	2955	9	findings	finding	NNS
cord-006860-a3b8hyyr	2955	10	from	from	IN
cord-006860-a3b8hyyr	2955	11	BREDBACKA	BREDBACKA	NNP
cord-006860-a3b8hyyr	2955	12	(	(	-LRB-
cord-006860-a3b8hyyr	2955	13	1994	1994	CD
cord-006860-a3b8hyyr	2955	14	)	)	-RRB-
cord-006860-a3b8hyyr	2955	15	.	.	.
cord-006860-a3b8hyyr	2956	1	Other	other	JJ
cord-006860-a3b8hyyr	2956	2	paramelers	parameler	NNS
cord-006860-a3b8hyyr	2956	3	were	be	VBD
cord-006860-a3b8hyyr	2956	4	less	less	RBR
cord-006860-a3b8hyyr	2956	5	predictive	predictive	JJ
cord-006860-a3b8hyyr	2956	6	than	than	IN
cord-006860-a3b8hyyr	2956	7	FtDP	FtDP	NNP
cord-006860-a3b8hyyr	2956	8	and	and	CC
cord-006860-a3b8hyyr	2956	9	SF	SF	NNP
cord-006860-a3b8hyyr	2956	10	.	.	.
cord-006860-a3b8hyyr	2957	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	2957	2	,	,	,
cord-006860-a3b8hyyr	2957	3	further	further	JJ
cord-006860-a3b8hyyr	2957	4	examinations	examination	NNS
cord-006860-a3b8hyyr	2957	5	are	be	VBP
cord-006860-a3b8hyyr	2957	6	necessary	necessary	JJ
cord-006860-a3b8hyyr	2957	7	to	to	TO
cord-006860-a3b8hyyr	2957	8	determine	determine	VB
cord-006860-a3b8hyyr	2957	9	the	the	DT
cord-006860-a3b8hyyr	2957	10	value	value	NN
cord-006860-a3b8hyyr	2957	11	of	of	IN
cord-006860-a3b8hyyr	2957	12	soluble	soluble	JJ
cord-006860-a3b8hyyr	2957	13	fibdn	fibdn	NNS
cord-006860-a3b8hyyr	2957	14	for	for	IN
cord-006860-a3b8hyyr	2957	15	a	a	DT
cord-006860-a3b8hyyr	2957	16	risk	risk	NN
cord-006860-a3b8hyyr	2957	17	prediction	prediction	NN
cord-006860-a3b8hyyr	2957	18	of	of	IN
cord-006860-a3b8hyyr	2957	19	bleeding	bleed	VBG
cord-006860-a3b8hyyr	2957	20	complications	complication	NNS
cord-006860-a3b8hyyr	2957	21	or	or	CC
cord-006860-a3b8hyyr	2957	22	DIC	DIC	NNP
cord-006860-a3b8hyyr	2957	23	.	.	.
cord-006860-a3b8hyyr	2958	1	A	a	DT
cord-006860-a3b8hyyr	2958	2	differentiation	differentiation	NN
cord-006860-a3b8hyyr	2958	3	of	of	IN
cord-006860-a3b8hyyr	2958	4	splits	split	NNS
cord-006860-a3b8hyyr	2958	5	products	product	NNS
cord-006860-a3b8hyyr	2958	6	deriving	derive	VBG
cord-006860-a3b8hyyr	2958	7	from	from	IN
cord-006860-a3b8hyyr	2958	8	either	either	CC
cord-006860-a3b8hyyr	2958	9	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	2958	10	,	,	,
cord-006860-a3b8hyyr	2958	11	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2958	12	or	or	CC
cord-006860-a3b8hyyr	2958	13	XL	XL	NNP
cord-006860-a3b8hyyr	2958	14	-	-	HYPH
cord-006860-a3b8hyyr	2958	15	fibrln	fibrln	NNP
cord-006860-a3b8hyyr	2958	16	will	will	MD
cord-006860-a3b8hyyr	2958	17	provide	provide	VB
cord-006860-a3b8hyyr	2958	18	further	further	JJ
cord-006860-a3b8hyyr	2958	19	insighls	insighls	NN
cord-006860-a3b8hyyr	2958	20	into	into	IN
cord-006860-a3b8hyyr	2958	21	fibrin(ogen	fibrin(ogen	NNP
cord-006860-a3b8hyyr	2958	22	)	)	-RRB-
cord-006860-a3b8hyyr	2958	23	metabolism	metabolism	NN
cord-006860-a3b8hyyr	2958	24	.	.	.
cord-006860-a3b8hyyr	2959	1	This	this	DT
cord-006860-a3b8hyyr	2959	2	study	study	NN
cord-006860-a3b8hyyr	2959	3	was	be	VBD
cord-006860-a3b8hyyr	2959	4	conducted	conduct	VBN
cord-006860-a3b8hyyr	2959	5	as	as	IN
cord-006860-a3b8hyyr	2959	6	a	a	DT
cord-006860-a3b8hyyr	2959	7	randomized	randomized	JJ
cord-006860-a3b8hyyr	2959	8	parallel	parallel	NN
cord-006860-a3b8hyyr	2959	9	-group	-group	NN
cord-006860-a3b8hyyr	2959	10	clinical	clinical	JJ
cord-006860-a3b8hyyr	2959	11	trial	trial	NN
cord-006860-a3b8hyyr	2959	12	comparing	compare	VBG
cord-006860-a3b8hyyr	2959	13	the	the	DT
cord-006860-a3b8hyyr	2959	14	safety	safety	NN
cord-006860-a3b8hyyr	2959	15	and	and	CC
cord-006860-a3b8hyyr	2959	16	efficacy	efficacy	NN
cord-006860-a3b8hyyr	2959	17	of	of	IN
cord-006860-a3b8hyyr	2959	18	a	a	DT
cord-006860-a3b8hyyr	2959	19	low	low	JJ
cord-006860-a3b8hyyr	2959	20	molecular	molecular	JJ
cord-006860-a3b8hyyr	2959	21	weight	weight	NN
cord-006860-a3b8hyyr	2959	22	heparin	heparin	NN
cord-006860-a3b8hyyr	2959	23	{	{	-LRB-
cord-006860-a3b8hyyr	2959	24	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2959	25	}	}	-RRB-
cord-006860-a3b8hyyr	2960	1	-Monoembolex	-Monoembolex	.
cord-006860-a3b8hyyr	2961	1	SANDOZ	SANDOZ	NNP
cord-006860-a3b8hyyr	2961	2	and	and	CC
cord-006860-a3b8hyyr	2961	3	unfractionated	unfractionated	JJ
cord-006860-a3b8hyyr	2961	4	standard	standard	JJ
cord-006860-a3b8hyyr	2961	5	heparin	heparin	JJ
cord-006860-a3b8hyyr	2961	6	glFH	glFH	NNP
cord-006860-a3b8hyyr	2961	7	)	)	-RRB-
cord-006860-a3b8hyyr	2961	8	for	for	IN
cord-006860-a3b8hyyr	2961	9	the	the	DT
cord-006860-a3b8hyyr	2961	10	perioperative	perioperative	JJ
cord-006860-a3b8hyyr	2961	11	prevention	prevention	NN
cord-006860-a3b8hyyr	2961	12	of	of	IN
cord-006860-a3b8hyyr	2961	13	venous	venous	JJ
cord-006860-a3b8hyyr	2961	14	thromboembolie	thromboembolie	NNP
cord-006860-a3b8hyyr	2961	15	disease	disease	NN
cord-006860-a3b8hyyr	2961	16	(	(	-LRB-
cord-006860-a3b8hyyr	2961	17	DVT	DVT	NNP
cord-006860-a3b8hyyr	2961	18	)	)	-RRB-
cord-006860-a3b8hyyr	2962	1	following	follow	VBG
cord-006860-a3b8hyyr	2962	2	major	major	JJ
cord-006860-a3b8hyyr	2962	3	surgms	surgms	NN
cord-006860-a3b8hyyr	2962	4	'	'	''
cord-006860-a3b8hyyr	2962	5	in	in	IN
cord-006860-a3b8hyyr	2962	6	patients	patient	NNS
cord-006860-a3b8hyyr	2962	7	with	with	IN
cord-006860-a3b8hyyr	2962	8	gynecologic	gynecologic	JJ
cord-006860-a3b8hyyr	2962	9	malignancy	malignancy	NN
cord-006860-a3b8hyyr	2962	10	..	..	.
cord-006860-a3b8hyyr	2963	1	Three	three	CD
cord-006860-a3b8hyyr	2963	2	hundred	hundred	CD
cord-006860-a3b8hyyr	2963	3	and	and	CC
cord-006860-a3b8hyyr	2963	4	twenty	twenty	CD
cord-006860-a3b8hyyr	2963	5	4	4	CD
cord-006860-a3b8hyyr	2963	6	women	woman	NNS
cord-006860-a3b8hyyr	2963	7	(	(	-LRB-
cord-006860-a3b8hyyr	2963	8	six	six	CD
cord-006860-a3b8hyyr	2963	9	drop	drop	NN
cord-006860-a3b8hyyr	2963	10	outsl	outsl	NNP
cord-006860-a3b8hyyr	2963	11	werr	werr	RB
cord-006860-a3b8hyyr	2963	12	randomized	randomize	VBD
cord-006860-a3b8hyyr	2963	13	and	and	CC
cord-006860-a3b8hyyr	2963	14	received	receive	VBD
cord-006860-a3b8hyyr	2963	15	either	either	CC
cord-006860-a3b8hyyr	2963	16	3	3	CD
cord-006860-a3b8hyyr	2963	17	times	time	NNS
cord-006860-a3b8hyyr	2963	18	daily	daily	JJ
cord-006860-a3b8hyyr	2963	19	5000	5000	CD
cord-006860-a3b8hyyr	2964	1	[	[	-LRB-
cord-006860-a3b8hyyr	2964	2	l	l	NNP
cord-006860-a3b8hyyr	2964	3	"	"	``
cord-006860-a3b8hyyr	2964	4	s.c	s.c	NNP
cord-006860-a3b8hyyr	2964	5	.	.	NNP
cord-006860-a3b8hyyr	2964	6	UL.'i	UL.'i	NNP
cord-006860-a3b8hyyr	2964	7	-	-	HYPH
cord-006860-a3b8hyyr	2964	8	i	i	NNP
cord-006860-a3b8hyyr	2964	9	(	(	-LRB-
cord-006860-a3b8hyyr	2964	10	SANDOZ	SANDOZ	NNP
cord-006860-a3b8hyyr	2964	11	Nuemberg	Nuemberg	NNP
cord-006860-a3b8hyyr	2964	12	Germany	Germany	NNP
cord-006860-a3b8hyyr	2964	13	]	]	-RRB-
cord-006860-a3b8hyyr	2965	1	(	(	-LRB-
cord-006860-a3b8hyyr	2965	2	n	n	NN
cord-006860-a3b8hyyr	2965	3	=	=	SYM
cord-006860-a3b8hyyr	2965	4	164	164	CD
cord-006860-a3b8hyyr	2965	5	)	)	-RRB-
cord-006860-a3b8hyyr	2965	6	or	or	CC
cord-006860-a3b8hyyr	2965	7	once	once	RB
cord-006860-a3b8hyyr	2965	8	a	a	DT
cord-006860-a3b8hyyr	2965	9	day	day	NN
cord-006860-a3b8hyyr	2965	10	t5000	t5000	CD
cord-006860-a3b8hyyr	2965	11	I~'V	i~'v	NN
cord-006860-a3b8hyyr	2965	12	'	'	''
cord-006860-a3b8hyyr	2965	13	.	.	.
cord-006860-a3b8hyyr	2966	1	Units	unit	NNS
cord-006860-a3b8hyyr	2966	2	s.c	s.c	NNP
cord-006860-a3b8hyyr	2966	3	.	.	.
cord-006860-a3b8hyyr	2967	1	Monoembolex	monoembolex	NN
cord-006860-a3b8hyyr	2968	1	(	(	-LRB-
cord-006860-a3b8hyyr	2968	2	n	n	NN
cord-006860-a3b8hyyr	2968	3	=	=	SYM
cord-006860-a3b8hyyr	2968	4	160	160	CD
cord-006860-a3b8hyyr	2968	5	)	)	-RRB-
cord-006860-a3b8hyyr	2968	6	plus	plus	CC
cord-006860-a3b8hyyr	2968	7	two	two	CD
cord-006860-a3b8hyyr	2968	8	placebo	placebo	NN
cord-006860-a3b8hyyr	2968	9	injections	injection	NNS
cord-006860-a3b8hyyr	2968	10	.	.	.
cord-006860-a3b8hyyr	2969	1	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	2969	2	therapy	therapy	NN
cord-006860-a3b8hyyr	2969	3	was	be	VBD
cord-006860-a3b8hyyr	2969	4	started	start	VBN
cord-006860-a3b8hyyr	2969	5	the	the	DT
cord-006860-a3b8hyyr	2969	6	morning	morning	NN
cord-006860-a3b8hyyr	2969	7	before	before	IN
cord-006860-a3b8hyyr	2969	8	opcrati(m	opcrati(m	NN
cord-006860-a3b8hyyr	2969	9	and	and	CC
cord-006860-a3b8hyyr	2969	10	continued	continue	VBD
cord-006860-a3b8hyyr	2969	11	until	until	IN
cord-006860-a3b8hyyr	2969	12	the	the	DT
cord-006860-a3b8hyyr	2969	13	7th	7th	JJ
cord-006860-a3b8hyyr	2969	14	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	2969	15	day	day	NN
cord-006860-a3b8hyyr	2969	16	.	.	.
cord-006860-a3b8hyyr	2970	1	Up	up	IN
cord-006860-a3b8hyyr	2970	2	to	to	IN
cord-006860-a3b8hyyr	2970	3	the	the	DT
cord-006860-a3b8hyyr	2970	4	10th	10th	JJ
cord-006860-a3b8hyyr	2970	5	poatop	poatop	NN
cord-006860-a3b8hyyr	2970	6	,	,	,
cord-006860-a3b8hyyr	2970	7	day	day	NN
cord-006860-a3b8hyyr	2970	8	the	the	DT
cord-006860-a3b8hyyr	2970	9	incidence	incidence	NN
cord-006860-a3b8hyyr	2970	10	of	of	IN
cord-006860-a3b8hyyr	2970	11	DVT	DVT	NNP
cord-006860-a3b8hyyr	2970	12	was	be	VBD
cord-006860-a3b8hyyr	2970	13	6.25	6.25	CD
cord-006860-a3b8hyyr	2970	14	%	%	NN
cord-006860-a3b8hyyr	2970	15	(	(	-LRB-
cord-006860-a3b8hyyr	2970	16	n	n	NN
cord-006860-a3b8hyyr	2970	17	=	=	SYM
cord-006860-a3b8hyyr	2970	18	10	10	CD
cord-006860-a3b8hyyr	2970	19	;	;	:
cord-006860-a3b8hyyr	2970	20	incl	incl	NNS
cord-006860-a3b8hyyr	2970	21	.	.	.
cord-006860-a3b8hyyr	2971	1	7	7	CD
cord-006860-a3b8hyyr	2971	2	pulmona~	pulmona~	NNS
cord-006860-a3b8hyyr	2971	3	embolisms	embolism	NNS
cord-006860-a3b8hyyr	2971	4	PE	PE	NNP
cord-006860-a3b8hyyr	2971	5	)	)	-RRB-
cord-006860-a3b8hyyr	2972	1	in	in	IN
cord-006860-a3b8hyyr	2972	2	the	the	DT
cord-006860-a3b8hyyr	2972	3	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2972	4	group	group	NN
cord-006860-a3b8hyyr	2972	5	and	and	CC
cord-006860-a3b8hyyr	2972	6	6.10	6.10	CD
cord-006860-a3b8hyyr	2972	7	%	%	NN
cord-006860-a3b8hyyr	2972	8	(	(	-LRB-
cord-006860-a3b8hyyr	2972	9	n	n	NN
cord-006860-a3b8hyyr	2972	10	=	=	SYM
cord-006860-a3b8hyyr	2972	11	10	10	CD
cord-006860-a3b8hyyr	2972	12	;	;	:
cord-006860-a3b8hyyr	2972	13	incl	incl	NNS
cord-006860-a3b8hyyr	2972	14	.	.	.
cord-006860-a3b8hyyr	2973	1	4	4	CD
cord-006860-a3b8hyyr	2973	2	PE	PE	NNP
cord-006860-a3b8hyyr	2973	3	}	}	-RRB-
cord-006860-a3b8hyyr	2973	4	in	in	IN
cord-006860-a3b8hyyr	2973	5	the	the	DT
cord-006860-a3b8hyyr	2973	6	UFH	UFH	NNP
cord-006860-a3b8hyyr	2973	7	group	group	NN
cord-006860-a3b8hyyr	2973	8	.	.	.
cord-006860-a3b8hyyr	2974	1	The	the	DT
cord-006860-a3b8hyyr	2974	2	overall	overall	JJ
cord-006860-a3b8hyyr	2974	3	incidence	incidence	NN
cord-006860-a3b8hyyr	2974	4	of	of	IN
cord-006860-a3b8hyyr	2974	5	clinically	clinically	RB
cord-006860-a3b8hyyr	2974	6	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	2974	7	wound	wound	NN
cord-006860-a3b8hyyr	2974	8	complications	complication	NNS
cord-006860-a3b8hyyr	2974	9	was	be	VBD
cord-006860-a3b8hyyr	2974	10	significantly	significantly	RB
cord-006860-a3b8hyyr	2974	11	decreased	decrease	VBN
cord-006860-a3b8hyyr	2974	12	in	in	IN
cord-006860-a3b8hyyr	2974	13	the	the	DT
cord-006860-a3b8hyyr	2974	14	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2974	15	group	group	NN
cord-006860-a3b8hyyr	2974	16	16.3	16.3	CD
cord-006860-a3b8hyyr	2974	17	%	%	NN
cord-006860-a3b8hyyr	2974	18	(	(	-LRB-
cord-006860-a3b8hyyr	2974	19	n	n	NN
cord-006860-a3b8hyyr	2974	20	=	=	SYM
cord-006860-a3b8hyyr	2974	21	2hi	2hi	NN
cord-006860-a3b8hyyr	2974	22	compared	compare	VBN
cord-006860-a3b8hyyr	2974	23	to	to	IN
cord-006860-a3b8hyyr	2974	24	the	the	DT
cord-006860-a3b8hyyr	2974	25	UFH	UFH	NNP
cord-006860-a3b8hyyr	2974	26	group	group	NN
cord-006860-a3b8hyyr	2974	27	26.8	26.8	CD
cord-006860-a3b8hyyr	2974	28	%	%	NN
cord-006860-a3b8hyyr	2974	29	{	{	-LRB-
cord-006860-a3b8hyyr	2974	30	n	n	NN
cord-006860-a3b8hyyr	2974	31	=	=	SYM
cord-006860-a3b8hyyr	2974	32	44	44	CD
cord-006860-a3b8hyyr	2974	33	;	;	:
cord-006860-a3b8hyyr	2974	34	p	p	NN
cord-006860-a3b8hyyr	2974	35	<	<	XX
cord-006860-a3b8hyyr	2974	36	0.0051	0.0051	CD
cord-006860-a3b8hyyr	2974	37	.	.	.
cord-006860-a3b8hyyr	2975	1	The	the	DT
cord-006860-a3b8hyyr	2975	2	incidence	incidence	NN
cord-006860-a3b8hyyr	2975	3	of	of	IN
cord-006860-a3b8hyyr	2975	4	major	major	JJ
cord-006860-a3b8hyyr	2975	5	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	2975	6	episodes	episode	NNS
cord-006860-a3b8hyyr	2975	7	was	be	VBD
cord-006860-a3b8hyyr	2975	8	9.4	9.4	CD
cord-006860-a3b8hyyr	2975	9	%	%	NN
cord-006860-a3b8hyyr	2975	10	in	in	IN
cord-006860-a3b8hyyr	2975	11	=	=	SYM
cord-006860-a3b8hyyr	2975	12	151	151	CD
cord-006860-a3b8hyyr	2975	13	in	in	IN
cord-006860-a3b8hyyr	2975	14	the	the	DT
cord-006860-a3b8hyyr	2975	15	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2975	16	group	group	NN
cord-006860-a3b8hyyr	2975	17	and	and	CC
cord-006860-a3b8hyyr	2975	18	14.0	14.0	CD
cord-006860-a3b8hyyr	2975	19	%	%	NN
cord-006860-a3b8hyyr	2976	1	/n	/n	NNP
cord-006860-a3b8hyyr	2977	1	=	=	SYM
cord-006860-a3b8hyyr	2977	2	23	23	CD
cord-006860-a3b8hyyr	2977	3	)	)	-RRB-
cord-006860-a3b8hyyr	2977	4	in	in	IN
cord-006860-a3b8hyyr	2977	5	the	the	DT
cord-006860-a3b8hyyr	2977	6	UFH	UFH	NNP
cord-006860-a3b8hyyr	2977	7	group	group	NN
cord-006860-a3b8hyyr	2977	8	.	.	.
cord-006860-a3b8hyyr	2978	1	This	this	DT
cord-006860-a3b8hyyr	2978	2	difference	difference	NN
cord-006860-a3b8hyyr	2978	3	was	be	VBD
cord-006860-a3b8hyyr	2978	4	not	not	RB
cord-006860-a3b8hyyr	2978	5	statisticaUy	statisticauy	NN
cord-006860-a3b8hyyr	2978	6	significant	significant	JJ
cord-006860-a3b8hyyr	2978	7	.	.	.
cord-006860-a3b8hyyr	2979	1	One	one	CD
cord-006860-a3b8hyyr	2979	2	case	case	NN
cord-006860-a3b8hyyr	2979	3	of	of	IN
cord-006860-a3b8hyyr	2979	4	fatal	fatal	JJ
cord-006860-a3b8hyyr	2979	5	PE	PE	NNP
cord-006860-a3b8hyyr	2979	6	was	be	VBD
cord-006860-a3b8hyyr	2979	7	observed	observe	VBN
cord-006860-a3b8hyyr	2979	8	in	in	IN
cord-006860-a3b8hyyr	2979	9	the	the	DT
cord-006860-a3b8hyyr	2979	10	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2979	11	-treated	-treate	VBD
cord-006860-a3b8hyyr	2979	12	group	group	NN
cord-006860-a3b8hyyr	2979	13	.	.	.
cord-006860-a3b8hyyr	2980	1	Five	five	CD
cord-006860-a3b8hyyr	2980	2	women	woman	NNS
cord-006860-a3b8hyyr	2980	3	deaths	death	NNS
cord-006860-a3b8hyyr	2980	4	in	in	IN
cord-006860-a3b8hyyr	2980	5	the	the	DT
cord-006860-a3b8hyyr	2980	6	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	2980	7	group	group	NN
cord-006860-a3b8hyyr	2980	8	were	be	VBD
cord-006860-a3b8hyyr	2980	9	observed	observe	VBN
cord-006860-a3b8hyyr	2980	10	during	during	IN
cord-006860-a3b8hyyr	2980	11	the	the	DT
cord-006860-a3b8hyyr	2980	12	study	study	NN
cord-006860-a3b8hyyr	2980	13	and	and	CC
cord-006860-a3b8hyyr	2980	14	3	3	CD
cord-006860-a3b8hyyr	2980	15	in	in	IN
cord-006860-a3b8hyyr	2980	16	the	the	DT
cord-006860-a3b8hyyr	2980	17	UFH	UFH	NNP
cord-006860-a3b8hyyr	2980	18	group	group	NN
cord-006860-a3b8hyyr	2980	19	.	.	.
cord-006860-a3b8hyyr	2981	1	This	this	DT
cord-006860-a3b8hyyr	2981	2	study	study	NN
cord-006860-a3b8hyyr	2981	3	demonstrates	demonstrate	VBZ
cord-006860-a3b8hyyr	2981	4	that	that	IN
cord-006860-a3b8hyyr	2981	5	the	the	DT
cord-006860-a3b8hyyr	2981	6	perioperative	perioperative	JJ
cord-006860-a3b8hyyr	2981	7	treaunent	treaunent	NN
cord-006860-a3b8hyyr	2981	8	of	of	IN
cord-006860-a3b8hyyr	2981	9	low	low	JJ
cord-006860-a3b8hyyr	2981	10	molecular	molecular	JJ
cord-006860-a3b8hyyr	2981	11	weight	weight	NN
cord-006860-a3b8hyyr	2981	12	heparins	heparin	NNS
cord-006860-a3b8hyyr	2981	13	is	be	VBZ
cord-006860-a3b8hyyr	2981	14	more	more	JJR
cord-006860-a3b8hyyr	2981	15	safety	safety	NN
cord-006860-a3b8hyyr	2981	16	than	than	IN
cord-006860-a3b8hyyr	2981	17	standard	standard	JJ
cord-006860-a3b8hyyr	2981	18	heparins	heparin	NNS
cord-006860-a3b8hyyr	2981	19	in	in	IN
cord-006860-a3b8hyyr	2981	20	gynecologic	gynecologic	JJ
cord-006860-a3b8hyyr	2981	21	-oncologic	-oncologic	JJ
cord-006860-a3b8hyyr	2981	22	patients	patient	NNS
cord-006860-a3b8hyyr	2981	23	undergoing	undergo	VBG
cord-006860-a3b8hyyr	2981	24	major	major	JJ
cord-006860-a3b8hyyr	2981	25	surge	surge	NN
cord-006860-a3b8hyyr	2981	26	.ry	.ry	.
cord-006860-a3b8hyyr	2981	27	.	.	.
cord-006860-a3b8hyyr	2982	1	However	however	RB
cord-006860-a3b8hyyr	2982	2	,	,	,
cord-006860-a3b8hyyr	2982	3	the	the	DT
cord-006860-a3b8hyyr	2982	4	incidence	incidence	NN
cord-006860-a3b8hyyr	2982	5	of	of	IN
cord-006860-a3b8hyyr	2982	6	thromboembohc	thromboembohc	NNP
cord-006860-a3b8hyyr	2982	7	complications	complication	NNS
cord-006860-a3b8hyyr	2982	8	is	be	VBZ
cord-006860-a3b8hyyr	2982	9	simmilar	simmilar	JJ
cord-006860-a3b8hyyr	2982	10	in	in	IN
cord-006860-a3b8hyyr	2982	11	both	both	DT
cord-006860-a3b8hyyr	2982	12	treatment	treatment	NN
cord-006860-a3b8hyyr	2982	13	regimes	regime	NNS
cord-006860-a3b8hyyr	2982	14	.	.	.
cord-006860-a3b8hyyr	2983	1	To	to	TO
cord-006860-a3b8hyyr	2983	2	explore	explore	VB
cord-006860-a3b8hyyr	2983	3	the	the	DT
cord-006860-a3b8hyyr	2983	4	effect	effect	NN
cord-006860-a3b8hyyr	2983	5	of	of	IN
cord-006860-a3b8hyyr	2983	6	targeting	target	VBG
cord-006860-a3b8hyyr	2983	7	an	an	DT
cord-006860-a3b8hyyr	2983	8	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	2983	9	to	to	IN
cord-006860-a3b8hyyr	2983	10	the	the	DT
cord-006860-a3b8hyyr	2983	11	surface	surface	NN
cord-006860-a3b8hyyr	2983	12	of	of	IN
cord-006860-a3b8hyyr	2983	13	a	a	DT
cord-006860-a3b8hyyr	2983	14	thrombus	thrombus	NN
cord-006860-a3b8hyyr	2983	15	,	,	,
cord-006860-a3b8hyyr	2983	16	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	2983	17	hirudin	hirudin	NN
cord-006860-a3b8hyyr	2983	18	(	(	-LRB-
cord-006860-a3b8hyyr	2983	19	Hir	Hir	NNP
cord-006860-a3b8hyyr	2983	20	)	)	-RRB-
cord-006860-a3b8hyyr	2983	21	was	be	VBD
cord-006860-a3b8hyyr	2983	22	covalently	covalently	RB
cord-006860-a3b8hyyr	2983	23	linked	link	VBN
cord-006860-a3b8hyyr	2983	24	to	to	IN
cord-006860-a3b8hyyr	2983	25	the	the	DT
cord-006860-a3b8hyyr	2983	26	Fab	Fab	NNP
cord-006860-a3b8hyyr	2983	27	'	'	POS
cord-006860-a3b8hyyr	2983	28	fragment	fragment	NN
cord-006860-a3b8hyyr	2983	29	of	of	IN
cord-006860-a3b8hyyr	2983	30	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2983	31	-	-	HYPH
cord-006860-a3b8hyyr	2983	32	specific	specific	JJ
cord-006860-a3b8hyyr	2983	33	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	2983	34	antibody	antibody	NN
cord-006860-a3b8hyyr	2983	35	59D8	59d8	CD
cord-006860-a3b8hyyr	2983	36	(	(	-LRB-
cord-006860-a3b8hyyr	2983	37	Fab	Fab	NNP
cord-006860-a3b8hyyr	2983	38	)	)	-RRB-
cord-006860-a3b8hyyr	2983	39	resulting	result	VBG
cord-006860-a3b8hyyr	2983	40	in	in	IN
cord-006860-a3b8hyyr	2983	41	a	a	DT
cord-006860-a3b8hyyr	2983	42	stable	stable	JJ
cord-006860-a3b8hyyr	2983	43	conjugate	conjugate	NN
cord-006860-a3b8hyyr	2983	44	(	(	-LRB-
cord-006860-a3b8hyyr	2983	45	Hir	Hir	NNP
cord-006860-a3b8hyyr	2983	46	-	-	HYPH
cord-006860-a3b8hyyr	2983	47	Fab	Fab	NNP
cord-006860-a3b8hyyr	2983	48	)	)	-RRB-
cord-006860-a3b8hyyr	2983	49	.	.	.
cord-006860-a3b8hyyr	2984	1	In	in	IN
cord-006860-a3b8hyyr	2984	2	vitro	vitro	FW
cord-006860-a3b8hyyr	2984	3	,	,	,
cord-006860-a3b8hyyr	2984	4	Hir	Hir	NNP
cord-006860-a3b8hyyr	2984	5	-	-	HYPH
cord-006860-a3b8hyyr	2984	6	Fab	Fab	NNP
cord-006860-a3b8hyyr	2984	7	was	be	VBD
cord-006860-a3b8hyyr	2984	8	9times	9times	CD
cord-006860-a3b8hyyr	2984	9	more	more	RBR
cord-006860-a3b8hyyr	2984	10	efficient	efficient	JJ
cord-006860-a3b8hyyr	2984	11	than	than	IN
cord-006860-a3b8hyyr	2984	12	Hir	Hir	NNP
cord-006860-a3b8hyyr	2984	13	alone	alone	RB
cord-006860-a3b8hyyr	2984	14	in	in	IN
cord-006860-a3b8hyyr	2984	15	inhibiting	inhibit	VBG
cord-006860-a3b8hyyr	2984	16	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2984	17	deposition	deposition	NN
cord-006860-a3b8hyyr	2984	18	on	on	IN
cord-006860-a3b8hyyr	2984	19	experimental	experimental	JJ
cord-006860-a3b8hyyr	2984	20	clot	clot	NN
cord-006860-a3b8hyyr	2984	21	surfaces	surface	NNS
cord-006860-a3b8hyyr	2984	22	in	in	IN
cord-006860-a3b8hyyr	2984	23	human	human	JJ
cord-006860-a3b8hyyr	2984	24	or	or	CC
cord-006860-a3b8hyyr	2984	25	baboon	baboon	NN
cord-006860-a3b8hyyr	2984	26	plasma	plasma	NN
cord-006860-a3b8hyyr	2984	27	(	(	-LRB-
cord-006860-a3b8hyyr	2984	28	p<0.01	p<0.01	NNP
cord-006860-a3b8hyyr	2984	29	)	)	-RRB-
cord-006860-a3b8hyyr	2984	30	.	.	.
cord-006860-a3b8hyyr	2985	1	To	to	TO
cord-006860-a3b8hyyr	2985	2	validate	validate	VB
cord-006860-a3b8hyyr	2985	3	these	these	DT
cord-006860-a3b8hyyr	2985	4	results	result	NNS
cord-006860-a3b8hyyr	2985	5	in	in	IN
cord-006860-a3b8hyyr	2985	6	vivo	vivo	NN
cord-006860-a3b8hyyr	2985	7	,	,	,
cord-006860-a3b8hyyr	2985	8	Hir	Hir	NNP
cord-006860-a3b8hyyr	2985	9	-	-	HYPH
cord-006860-a3b8hyyr	2985	10	Fab	Fab	NNP
cord-006860-a3b8hyyr	2985	11	was	be	VBD
cord-006860-a3b8hyyr	2985	12	compared	compare	VBN
cord-006860-a3b8hyyr	2985	13	to	to	IN
cord-006860-a3b8hyyr	2985	14	Hir	Hir	NNP
cord-006860-a3b8hyyr	2985	15	in	in	IN
cord-006860-a3b8hyyr	2985	16	a	a	DT
cord-006860-a3b8hyyr	2985	17	baboon	baboon	NN
cord-006860-a3b8hyyr	2985	18	model	model	NN
cord-006860-a3b8hyyr	2985	19	.	.	.
cord-006860-a3b8hyyr	2986	1	The	the	DT
cord-006860-a3b8hyyr	2986	2	deposition	deposition	NN
cord-006860-a3b8hyyr	2986	3	of	of	IN
cord-006860-a3b8hyyr	2986	4	Ill	Ill	NNP
cord-006860-a3b8hyyr	2986	5	-	-	HYPH
cord-006860-a3b8hyyr	2986	6	In	in	IN
cord-006860-a3b8hyyr	2986	7	-	-	HYPH
cord-006860-a3b8hyyr	2986	8	labeled	label	VBN
cord-006860-a3b8hyyr	2986	9	platelets	platelet	NNS
cord-006860-a3b8hyyr	2986	10	onto	onto	IN
cord-006860-a3b8hyyr	2986	11	a	a	DT
cord-006860-a3b8hyyr	2986	12	segment	segment	NN
cord-006860-a3b8hyyr	2986	13	of	of	IN
cord-006860-a3b8hyyr	2986	14	Dacron	Dacron	NNP
cord-006860-a3b8hyyr	2986	15	vascular	vascular	JJ
cord-006860-a3b8hyyr	2986	16	graft	graft	NN
cord-006860-a3b8hyyr	2986	17	present	present	NN
cord-006860-a3b8hyyr	2986	18	in	in	IN
cord-006860-a3b8hyyr	2986	19	an	an	DT
cord-006860-a3b8hyyr	2986	20	extracorporeal	extracorporeal	JJ
cord-006860-a3b8hyyr	2986	21	arteriovenous	arteriovenous	JJ
cord-006860-a3b8hyyr	2986	22	shunt	shunt	NN
cord-006860-a3b8hyyr	2986	23	was	be	VBD
cord-006860-a3b8hyyr	2986	24	measured	measure	VBN
cord-006860-a3b8hyyr	2986	25	.	.	.
cord-006860-a3b8hyyr	2987	1	Blood	blood	NN
cord-006860-a3b8hyyr	2987	2	flow	flow	NN
cord-006860-a3b8hyyr	2987	3	rate	rate	NN
cord-006860-a3b8hyyr	2987	4	was	be	VBD
cord-006860-a3b8hyyr	2987	5	40	40	CD
cord-006860-a3b8hyyr	2987	6	ml	ml	NNS
cord-006860-a3b8hyyr	2987	7	/	/	SYM
cord-006860-a3b8hyyr	2987	8	min	min	NN
cord-006860-a3b8hyyr	2987	9	.	.	.
cord-006860-a3b8hyyr	2988	1	One	one	CD
cord-006860-a3b8hyyr	2988	2	hour	hour	NN
cord-006860-a3b8hyyr	2988	3	local	local	JJ
cord-006860-a3b8hyyr	2988	4	infusions	infusion	NNS
cord-006860-a3b8hyyr	2988	5	of	of	IN
cord-006860-a3b8hyyr	2988	6	4500	4500	CD
cord-006860-a3b8hyyr	2988	7	ATU	atu	NN
cord-006860-a3b8hyyr	2988	8	of	of	IN
cord-006860-a3b8hyyr	2988	9	either	either	CC
cord-006860-a3b8hyyr	2988	10	Hir	Hir	NNP
cord-006860-a3b8hyyr	2988	11	-	-	HYPH
cord-006860-a3b8hyyr	2988	12	Fab	Fab	NNP
cord-006860-a3b8hyyr	2988	13	or	or	CC
cord-006860-a3b8hyyr	2988	14	Hir	Hir	NNP
cord-006860-a3b8hyyr	2988	15	resulted	result	VBD
cord-006860-a3b8hyyr	2988	16	in	in	IN
cord-006860-a3b8hyyr	2988	17	deposition	deposition	NN
cord-006860-a3b8hyyr	2988	18	of	of	IN
cord-006860-a3b8hyyr	2988	19	0.16	0.16	CD
cord-006860-a3b8hyyr	2988	20	x	x	SYM
cord-006860-a3b8hyyr	2988	21	109	109	CD
cord-006860-a3b8hyyr	2988	22	and	and	CC
cord-006860-a3b8hyyr	2988	23	2.17	2.17	CD
cord-006860-a3b8hyyr	2988	24	x	x	SYM
cord-006860-a3b8hyyr	2988	25	109	109	CD
cord-006860-a3b8hyyr	2988	26	plate!ets	plate!ets	CD
cord-006860-a3b8hyyr	2988	27	,	,	,
cord-006860-a3b8hyyr	2988	28	respectively	respectively	RB
cord-006860-a3b8hyyr	2988	29	.	.	.
cord-006860-a3b8hyyr	2989	1	Equieffective	equieffective	NN
cord-006860-a3b8hyyr	2989	2	dosages	dosage	NNS
cord-006860-a3b8hyyr	2989	3	were	be	VBD
cord-006860-a3b8hyyr	2989	4	2000	2000	CD
cord-006860-a3b8hyyr	2990	1	ATU	ATU	NNP
cord-006860-a3b8hyyr	2990	2	Hir	Hir	NNP
cord-006860-a3b8hyyr	2990	3	-	-	HYPH
cord-006860-a3b8hyyr	2990	4	Fab	Fab	NNP
cord-006860-a3b8hyyr	2990	5	and	and	CC
cord-006860-a3b8hyyr	2990	6	9000	9000	CD
cord-006860-a3b8hyyr	2991	1	ATU	ATU	NNP
cord-006860-a3b8hyyr	2991	2	Hir	Hir	NNP
cord-006860-a3b8hyyr	2991	3	resulting	result	VBG
cord-006860-a3b8hyyr	2991	4	in	in	IN
cord-006860-a3b8hyyr	2991	5	deposition	deposition	NN
cord-006860-a3b8hyyr	2991	6	of	of	IN
cord-006860-a3b8hyyr	2991	7	1.06	1.06	CD
cord-006860-a3b8hyyr	2991	8	x	x	SYM
cord-006860-a3b8hyyr	2991	9	109	109	CD
cord-006860-a3b8hyyr	2991	10	and	and	CC
cord-006860-a3b8hyyr	2991	11	0.93	0.93	CD
cord-006860-a3b8hyyr	2991	12	x	x	SYM
cord-006860-a3b8hyyr	2991	13	109	109	CD
cord-006860-a3b8hyyr	2991	14	platelets	platelet	NNS
cord-006860-a3b8hyyr	2991	15	,	,	,
cord-006860-a3b8hyyr	2991	16	respectively	respectively	RB
cord-006860-a3b8hyyr	2991	17	.	.	.
cord-006860-a3b8hyyr	2992	1	Based	base	VBN
cord-006860-a3b8hyyr	2992	2	on	on	IN
cord-006860-a3b8hyyr	2992	3	full	full	JJ
cord-006860-a3b8hyyr	2992	4	dose	dose	NN
cord-006860-a3b8hyyr	2992	5	response	response	NN
cord-006860-a3b8hyyr	2992	6	curves	curve	NNS
cord-006860-a3b8hyyr	2992	7	(	(	-LRB-
cord-006860-a3b8hyyr	2992	8	n	n	NN
cord-006860-a3b8hyyr	2992	9	=	=	SYM
cord-006860-a3b8hyyr	2992	10	14	14	CD
cord-006860-a3b8hyyr	2992	11	)	)	-RRB-
cord-006860-a3b8hyyr	2992	12	,	,	,
cord-006860-a3b8hyyr	2992	13	Hir	Hir	NNP
cord-006860-a3b8hyyr	2992	14	-	-	HYPH
cord-006860-a3b8hyyr	2992	15	Fab	Fab	NNP
cord-006860-a3b8hyyr	2992	16	was	be	VBD
cord-006860-a3b8hyyr	2992	17	found	find	VBN
cord-006860-a3b8hyyr	2992	18	to	to	TO
cord-006860-a3b8hyyr	2992	19	be	be	VB
cord-006860-a3b8hyyr	2992	20	>	>	NFP
cord-006860-a3b8hyyr	2992	21	4.5-fold	4.5-fold	CD
cord-006860-a3b8hyyr	2992	22	more	more	RBR
cord-006860-a3b8hyyr	2992	23	potent	potent	JJ
cord-006860-a3b8hyyr	2992	24	(	(	-LRB-
cord-006860-a3b8hyyr	2992	25	based	base	VBN
cord-006860-a3b8hyyr	2992	26	on	on	IN
cord-006860-a3b8hyyr	2992	27	activity	activity	NN
cord-006860-a3b8hyyr	2992	28	)	)	-RRB-
cord-006860-a3b8hyyr	2992	29	than	than	IN
cord-006860-a3b8hyyr	2992	30	Hir	Hir	NNP
cord-006860-a3b8hyyr	2992	31	.	.	.
cord-006860-a3b8hyyr	2993	1	Because	because	IN
cord-006860-a3b8hyyr	2993	2	of	of	IN
cord-006860-a3b8hyyr	2993	3	the	the	DT
cord-006860-a3b8hyyr	2993	4	small	small	JJ
cord-006860-a3b8hyyr	2993	5	total	total	JJ
cord-006860-a3b8hyyr	2993	6	amounts	amount	NNS
cord-006860-a3b8hyyr	2993	7	of	of	IN
cord-006860-a3b8hyyr	2993	8	antithrombins	antithrombin	NNS
cord-006860-a3b8hyyr	2993	9	used	use	VBN
cord-006860-a3b8hyyr	2993	10	and	and	CC
cord-006860-a3b8hyyr	2993	11	the	the	DT
cord-006860-a3b8hyyr	2993	12	short	short	JJ
cord-006860-a3b8hyyr	2993	13	duration	duration	NN
cord-006860-a3b8hyyr	2993	14	of	of	IN
cord-006860-a3b8hyyr	2993	15	these	these	DT
cord-006860-a3b8hyyr	2993	16	experiments	experiment	NNS
cord-006860-a3b8hyyr	2993	17	,	,	,
cord-006860-a3b8hyyr	2993	18	no	no	DT
cord-006860-a3b8hyyr	2993	19	significant	significant	JJ
cord-006860-a3b8hyyr	2993	20	systemic	systemic	JJ
cord-006860-a3b8hyyr	2993	21	effects	effect	NNS
cord-006860-a3b8hyyr	2993	22	were	be	VBD
cord-006860-a3b8hyyr	2993	23	observed	observe	VBN
cord-006860-a3b8hyyr	2993	24	.	.	.
cord-006860-a3b8hyyr	2994	1	Thus	thus	RB
cord-006860-a3b8hyyr	2994	2	,	,	,
cord-006860-a3b8hyyr	2994	3	fibrin	fibrin	NN
cord-006860-a3b8hyyr	2994	4	-	-	HYPH
cord-006860-a3b8hyyr	2994	5	targeted	target	VBN
cord-006860-a3b8hyyr	2994	6	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	2994	7	hirudin	hirudin	NN
cord-006860-a3b8hyyr	2994	8	prevents	prevent	VBZ
cord-006860-a3b8hyyr	2994	9	platelet	platelet	NN
cord-006860-a3b8hyyr	2994	10	deposition	deposition	NN
cord-006860-a3b8hyyr	2994	11	and	and	CC
cord-006860-a3b8hyyr	2994	12	thrombus	thrombus	NN
cord-006860-a3b8hyyr	2994	13	formation	formation	NN
cord-006860-a3b8hyyr	2994	14	more	more	RBR
cord-006860-a3b8hyyr	2994	15	effectively	effectively	RB
cord-006860-a3b8hyyr	2994	16	than	than	IN
cord-006860-a3b8hyyr	2994	17	uncoupled	uncoupled	JJ
cord-006860-a3b8hyyr	2994	18	hirudin	hirudin	NN
cord-006860-a3b8hyyr	2994	19	in	in	IN
cord-006860-a3b8hyyr	2994	20	vitro	vitro	FW
cord-006860-a3b8hyyr	2994	21	and	and	CC
cord-006860-a3b8hyyr	2994	22	in	in	IN
cord-006860-a3b8hyyr	2994	23	an	an	DT
cord-006860-a3b8hyyr	2994	24	in	in	IN
cord-006860-a3b8hyyr	2994	25	vivo	vivo	NN
cord-006860-a3b8hyyr	2994	26	primate	primate	NN
cord-006860-a3b8hyyr	2994	27	model	model	NN
cord-006860-a3b8hyyr	2994	28	.	.	.
cord-006860-a3b8hyyr	2995	1	Triabin	Triabin	NNP
cord-006860-a3b8hyyr	2995	2	,	,	,
cord-006860-a3b8hyyr	2995	3	a	a	DT
cord-006860-a3b8hyyr	2995	4	17	17	CD
cord-006860-a3b8hyyr	2995	5	kDa	kDa	NNP
cord-006860-a3b8hyyr	2995	6	protein	protein	NN
cord-006860-a3b8hyyr	2995	7	from	from	IN
cord-006860-a3b8hyyr	2995	8	the	the	DT
cord-006860-a3b8hyyr	2995	9	saliva	saliva	NN
cord-006860-a3b8hyyr	2995	10	of	of	IN
cord-006860-a3b8hyyr	2995	11	the	the	DT
cord-006860-a3b8hyyr	2995	12	assassin	assassin	NN
cord-006860-a3b8hyyr	2995	13	bug	bug	NN
cord-006860-a3b8hyyr	2995	14	Triatoma	Triatoma	NNP
cord-006860-a3b8hyyr	2995	15	pallidipennis	pallidipennis	NNP
cord-006860-a3b8hyyr	2995	16	,	,	,
cord-006860-a3b8hyyr	2995	17	is	be	VBZ
cord-006860-a3b8hyyr	2995	18	a	a	DT
cord-006860-a3b8hyyr	2995	19	new	new	JJ
cord-006860-a3b8hyyr	2995	20	specific	specific	JJ
cord-006860-a3b8hyyr	2995	21	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	2995	22	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	2995	23	(	(	-LRB-
cord-006860-a3b8hyyr	2995	24	1	1	CD
cord-006860-a3b8hyyr	2995	25	)	)	-RRB-
cord-006860-a3b8hyyr	2995	26	.	.	.
cord-006860-a3b8hyyr	2996	1	tt	tt	NNP
cord-006860-a3b8hyyr	2996	2	does	do	VBZ
cord-006860-a3b8hyyr	2996	3	not	not	RB
cord-006860-a3b8hyyr	2996	4	block	block	VB
cord-006860-a3b8hyyr	2996	5	the	the	DT
cord-006860-a3b8hyyr	2996	6	catalytic	catalytic	JJ
cord-006860-a3b8hyyr	2996	7	center	center	NN
cord-006860-a3b8hyyr	2996	8	but	but	CC
cord-006860-a3b8hyyr	2996	9	interferes	interfere	VBZ
cord-006860-a3b8hyyr	2996	10	with	with	IN
cord-006860-a3b8hyyr	2996	11	the	the	DT
cord-006860-a3b8hyyr	2996	12	anionbinding	anionbinde	VBG
cord-006860-a3b8hyyr	2996	13	exosite	exosite	NNP
cord-006860-a3b8hyyr	2996	14	of	of	IN
cord-006860-a3b8hyyr	2996	15	thrombin	thrombin	NN
cord-006860-a3b8hyyr	2996	16	.	.	.
cord-006860-a3b8hyyr	2997	1	The	the	DT
cord-006860-a3b8hyyr	2997	2	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	2997	3	protein	protein	NN
cord-006860-a3b8hyyr	2997	4	was	be	VBD
cord-006860-a3b8hyyr	2997	5	produced	produce	VBN
cord-006860-a3b8hyyr	2997	6	with	with	IN
cord-006860-a3b8hyyr	2997	7	the	the	DT
cord-006860-a3b8hyyr	2997	8	baculovirus	baculovirus	NN
cord-006860-a3b8hyyr	2997	9	/	/	SYM
cord-006860-a3b8hyyr	2997	10	insect	insect	NN
cord-006860-a3b8hyyr	2997	11	cell	cell	NN
cord-006860-a3b8hyyr	2997	12	system	system	NN
cord-006860-a3b8hyyr	2997	13	and	and	CC
cord-006860-a3b8hyyr	2997	14	used	use	VBD
cord-006860-a3b8hyyr	2997	15	to	to	TO
cord-006860-a3b8hyyr	2997	16	study	study	VB
cord-006860-a3b8hyyr	2997	17	the	the	DT
cord-006860-a3b8hyyr	2997	18	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	2997	19	effect	effect	NN
cord-006860-a3b8hyyr	2997	20	of	of	IN
cord-006860-a3b8hyyr	2997	21	triabin	triabin	NN
cord-006860-a3b8hyyr	2997	22	on	on	IN
cord-006860-a3b8hyyr	2997	23	thrombin	thrombin	NN
cord-006860-a3b8hyyr	2997	24	-	-	HYPH
cord-006860-a3b8hyyr	2997	25	induced	induce	VBN
cord-006860-a3b8hyyr	2997	26	responses	response	NNS
cord-006860-a3b8hyyr	2997	27	of	of	IN
cord-006860-a3b8hyyr	2997	28	human	human	JJ
cord-006860-a3b8hyyr	2997	29	blood	blood	NN
cord-006860-a3b8hyyr	2997	30	platelets	platelet	NNS
cord-006860-a3b8hyyr	2997	31	and	and	CC
cord-006860-a3b8hyyr	2997	32	blood	blood	NN
cord-006860-a3b8hyyr	2997	33	vessels	vessel	NNS
cord-006860-a3b8hyyr	2997	34	.	.	.
cord-006860-a3b8hyyr	2998	1	Aggregation	aggregation	NN
cord-006860-a3b8hyyr	2998	2	of	of	IN
cord-006860-a3b8hyyr	2998	3	platelets	platelet	NNS
cord-006860-a3b8hyyr	2998	4	in	in	IN
cord-006860-a3b8hyyr	2998	5	Tyrode	Tyrode	NNP
cord-006860-a3b8hyyr	2998	6	's	's	POS
cord-006860-a3b8hyyr	2998	7	solution	solution	NN
cord-006860-a3b8hyyr	2998	8	was	be	VBD
cord-006860-a3b8hyyr	2998	9	measured	measure	VBN
cord-006860-a3b8hyyr	2998	10	turbidimetrically	turbidimetrically	RB
cord-006860-a3b8hyyr	2998	11	at	at	IN
cord-006860-a3b8hyyr	2998	12	37	37	CD
cord-006860-a3b8hyyr	2998	13	°	°	NN
cord-006860-a3b8hyyr	2998	14	C	c	NN
cord-006860-a3b8hyyr	2998	15	.	.	.
cord-006860-a3b8hyyr	2999	1	For	for	IN
cord-006860-a3b8hyyr	2999	2	the	the	DT
cord-006860-a3b8hyyr	2999	3	studies	study	NNS
cord-006860-a3b8hyyr	2999	4	on	on	IN
cord-006860-a3b8hyyr	2999	5	blood	blood	NN
cord-006860-a3b8hyyr	2999	6	vessels	vessel	NNS
cord-006860-a3b8hyyr	2999	7	rings	ring	NNS
cord-006860-a3b8hyyr	2999	8	(	(	-LRB-
cord-006860-a3b8hyyr	2999	9	2	2	CD
cord-006860-a3b8hyyr	2999	10	-	-	SYM
cord-006860-a3b8hyyr	2999	11	3	3	CD
cord-006860-a3b8hyyr	2999	12	mm	mm	NN
cord-006860-a3b8hyyr	2999	13	)	)	-RRB-
cord-006860-a3b8hyyr	2999	14	from	from	IN
cord-006860-a3b8hyyr	2999	15	small	small	JJ
cord-006860-a3b8hyyr	2999	16	porcine	porcine	JJ
cord-006860-a3b8hyyr	2999	17	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	2999	18	arteries	artery	NNS
cord-006860-a3b8hyyr	2999	19	were	be	VBD
cord-006860-a3b8hyyr	2999	20	placed	place	VBN
cord-006860-a3b8hyyr	2999	21	in	in	IN
cord-006860-a3b8hyyr	2999	22	organ	organ	NN
cord-006860-a3b8hyyr	2999	23	baths	bath	NNS
cord-006860-a3b8hyyr	2999	24	for	for	IN
cord-006860-a3b8hyyr	2999	25	isometric	isometric	JJ
cord-006860-a3b8hyyr	2999	26	tension	tension	NN
cord-006860-a3b8hyyr	2999	27	recording	recording	NN
cord-006860-a3b8hyyr	2999	28	.	.	.
cord-006860-a3b8hyyr	3000	1	The	the	DT
cord-006860-a3b8hyyr	3000	2	integrity	integrity	NN
cord-006860-a3b8hyyr	3000	3	of	of	IN
cord-006860-a3b8hyyr	3000	4	the	the	DT
cord-006860-a3b8hyyr	3000	5	endothelium	endothelium	NN
cord-006860-a3b8hyyr	3000	6	was	be	VBD
cord-006860-a3b8hyyr	3000	7	assessed	assess	VBN
cord-006860-a3b8hyyr	3000	8	by	by	IN
cord-006860-a3b8hyyr	3000	9	the	the	DT
cord-006860-a3b8hyyr	3000	10	relaxant	relaxant	NN
cord-006860-a3b8hyyr	3000	11	response	response	NN
cord-006860-a3b8hyyr	3000	12	to	to	IN
cord-006860-a3b8hyyr	3000	13	bradykinin	bradykinin	NN
cord-006860-a3b8hyyr	3000	14	.	.	.
cord-006860-a3b8hyyr	3001	1	Like	like	IN
cord-006860-a3b8hyyr	3001	2	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3001	3	,	,	,
cord-006860-a3b8hyyr	3001	4	triabin	triabin	NNP
cord-006860-a3b8hyyr	3001	5	inhibited	inhibit	VBD
cord-006860-a3b8hyyr	3001	6	the	the	DT
cord-006860-a3b8hyyr	3001	7	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3001	8	(	(	-LRB-
cord-006860-a3b8hyyr	3001	9	0.1	0.1	CD
cord-006860-a3b8hyyr	3001	10	U	U	NNP
cord-006860-a3b8hyyr	3001	11	/	/	SYM
cord-006860-a3b8hyyr	3001	12	ml)-induced	ml)-induce	VBN
cord-006860-a3b8hyyr	3001	13	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3001	14	of	of	IN
cord-006860-a3b8hyyr	3001	15	washed	wash	VBN
cord-006860-a3b8hyyr	3001	16	human	human	JJ
cord-006860-a3b8hyyr	3001	17	platelets	platelet	NNS
cord-006860-a3b8hyyr	3001	18	at	at	IN
cord-006860-a3b8hyyr	3001	19	nanomolar	nanomolar	NNP
cord-006860-a3b8hyyr	3001	20	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3002	1	(	(	-LRB-
cord-006860-a3b8hyyr	3002	2	EC50	EC50	NNP
cord-006860-a3b8hyyr	3002	3	=	=	SYM
cord-006860-a3b8hyyr	3002	4	2.6	2.6	CD
cord-006860-a3b8hyyr	3002	5	nmol	nmol	JJ
cord-006860-a3b8hyyr	3002	6	/	/	SYM
cord-006860-a3b8hyyr	3002	7	l	l	NN
cord-006860-a3b8hyyr	3002	8	)	)	-RRB-
cord-006860-a3b8hyyr	3002	9	;	;	.
cord-006860-a3b8hyyr	3003	1	whereas	whereas	IN
cord-006860-a3b8hyyr	3003	2	the	the	DT
cord-006860-a3b8hyyr	3003	3	ADP	ADP	NNP
cord-006860-a3b8hyyr	3003	4	-	-	:
cord-006860-a3b8hyyr	3003	5	and	and	CC
cord-006860-a3b8hyyr	3003	6	collagen	collagen	NN
cord-006860-a3b8hyyr	3003	7	-	-	HYPH
cord-006860-a3b8hyyr	3003	8	induced	induce	VBN
cord-006860-a3b8hyyr	3003	9	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3003	10	were	be	VBD
cord-006860-a3b8hyyr	3003	11	not	not	RB
cord-006860-a3b8hyyr	3003	12	suppressed	suppress	VBN
cord-006860-a3b8hyyr	3003	13	.	.	.
cord-006860-a3b8hyyr	3004	1	In	in	IN
cord-006860-a3b8hyyr	3004	2	PGF2c~-precontracted	pgf2c~-precontracted	JJ
cord-006860-a3b8hyyr	3004	3	porcine	porcine	JJ
cord-006860-a3b8hyyr	3004	4	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	3004	5	arteries	artery	NNS
cord-006860-a3b8hyyr	3004	6	,	,	,
cord-006860-a3b8hyyr	3004	7	the	the	DT
cord-006860-a3b8hyyr	3004	8	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3004	9	(	(	-LRB-
cord-006860-a3b8hyyr	3004	10	0.2	0.2	CD
cord-006860-a3b8hyyr	3004	11	U	u	NN
cord-006860-a3b8hyyr	3004	12	/	/	SYM
cord-006860-a3b8hyyr	3004	13	ml)-induced	ml)-induce	VBN
cord-006860-a3b8hyyr	3004	14	endothelium	endothelium	NN
cord-006860-a3b8hyyr	3004	15	-	-	HYPH
cord-006860-a3b8hyyr	3004	16	dependent	dependent	JJ
cord-006860-a3b8hyyr	3004	17	relaxation	relaxation	NN
cord-006860-a3b8hyyr	3004	18	was	be	VBD
cord-006860-a3b8hyyr	3004	19	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	3004	20	by	by	IN
cord-006860-a3b8hyyr	3004	21	triabin	triabin	NNP
cord-006860-a3b8hyyr	3004	22	in	in	IN
cord-006860-a3b8hyyr	3004	23	the	the	DT
cord-006860-a3b8hyyr	3004	24	same	same	JJ
cord-006860-a3b8hyyr	3004	25	concentration	concentration	NN
cord-006860-a3b8hyyr	3004	26	range	range	NN
cord-006860-a3b8hyyr	3004	27	as	as	IN
cord-006860-a3b8hyyr	3004	28	found	find	VBN
cord-006860-a3b8hyyr	3004	29	for	for	IN
cord-006860-a3b8hyyr	3004	30	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3004	31	of	of	IN
cord-006860-a3b8hyyr	3004	32	platelet	platelet	NN
cord-006860-a3b8hyyr	3004	33	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3004	34	.	.	.
cord-006860-a3b8hyyr	3005	1	Higher	high	JJR
cord-006860-a3b8hyyr	3005	2	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3005	3	of	of	IN
cord-006860-a3b8hyyr	3005	4	triabin	triabin	NNP
cord-006860-a3b8hyyr	3005	5	were	be	VBD
cord-006860-a3b8hyyr	3005	6	required	require	VBN
cord-006860-a3b8hyyr	3005	7	fo	fo	TO
cord-006860-a3b8hyyr	3005	8	affect	affect	VB
cord-006860-a3b8hyyr	3005	9	the	the	DT
cord-006860-a3b8hyyr	3005	10	contractile	contractile	JJ
cord-006860-a3b8hyyr	3005	11	response	response	NN
cord-006860-a3b8hyyr	3005	12	of	of	IN
cord-006860-a3b8hyyr	3005	13	endothelium	endothelium	NN
cord-006860-a3b8hyyr	3005	14	-	-	HYPH
cord-006860-a3b8hyyr	3005	15	denuded	denude	VBN
cord-006860-a3b8hyyr	3005	16	porcine	porcine	JJ
cord-006860-a3b8hyyr	3005	17	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	3005	18	arteries	artery	NNS
cord-006860-a3b8hyyr	3005	19	to	to	IN
cord-006860-a3b8hyyr	3005	20	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3005	21	(	(	-LRB-
cord-006860-a3b8hyyr	3005	22	1	1	CD
cord-006860-a3b8hyyr	3005	23	U	u	NN
cord-006860-a3b8hyyr	3005	24	/	/	SYM
cord-006860-a3b8hyyr	3005	25	ml	ml	NN
cord-006860-a3b8hyyr	3005	26	)	)	-RRB-
cord-006860-a3b8hyyr	3005	27	.	.	.
cord-006860-a3b8hyyr	3006	1	In	in	IN
cord-006860-a3b8hyyr	3006	2	all	all	PDT
cord-006860-a3b8hyyr	3006	3	these	these	DT
cord-006860-a3b8hyyr	3006	4	assays	assay	NNS
cord-006860-a3b8hyyr	3006	5	,	,	,
cord-006860-a3b8hyyr	3006	6	the	the	DT
cord-006860-a3b8hyyr	3006	7	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	3006	8	potency	potency	NN
cord-006860-a3b8hyyr	3006	9	of	of	IN
cord-006860-a3b8hyyr	3006	10	triabin	triabin	NNP
cord-006860-a3b8hyyr	3006	11	was	be	VBD
cord-006860-a3b8hyyr	3006	12	dependent	dependent	JJ
cord-006860-a3b8hyyr	3006	13	on	on	IN
cord-006860-a3b8hyyr	3006	14	the	the	DT
cord-006860-a3b8hyyr	3006	15	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3006	16	concentration	concentration	NN
cord-006860-a3b8hyyr	3006	17	used	use	VBN
cord-006860-a3b8hyyr	3006	18	.	.	.
cord-006860-a3b8hyyr	3007	1	These	these	DT
cord-006860-a3b8hyyr	3007	2	studies	study	NNS
cord-006860-a3b8hyyr	3007	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	3007	4	that	that	IN
cord-006860-a3b8hyyr	3007	5	the	the	DT
cord-006860-a3b8hyyr	3007	6	new	new	JJ
cord-006860-a3b8hyyr	3007	7	anion	anion	NN
cord-006860-a3b8hyyr	3007	8	-	-	HYPH
cord-006860-a3b8hyyr	3007	9	binding	bind	VBG
cord-006860-a3b8hyyr	3007	10	exosite	exosite	NNP
cord-006860-a3b8hyyr	3007	11	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3007	12	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3007	13	triabin	triabin	NNP
cord-006860-a3b8hyyr	3007	14	is	be	VBZ
cord-006860-a3b8hyyr	3007	15	one	one	CD
cord-006860-a3b8hyyr	3007	16	of	of	IN
cord-006860-a3b8hyyr	3007	17	the	the	DT
cord-006860-a3b8hyyr	3007	18	most	most	RBS
cord-006860-a3b8hyyr	3007	19	potent	potent	JJ
cord-006860-a3b8hyyr	3007	20	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3007	21	of	of	IN
cord-006860-a3b8hyyr	3007	22	the	the	DT
cord-006860-a3b8hyyr	3007	23	thrombin	thrombin	RB
cord-006860-a3b8hyyr	3007	24	-	-	HYPH
cord-006860-a3b8hyyr	3007	25	mediated	mediate	VBN
cord-006860-a3b8hyyr	3007	26	cellular	cellular	JJ
cord-006860-a3b8hyyr	3007	27	effects	effect	NNS
cord-006860-a3b8hyyr	3007	28	.	.	.
cord-006860-a3b8hyyr	3008	1	Dept	Dept	NNP
cord-006860-a3b8hyyr	3008	2	.	.	.
cord-006860-a3b8hyyr	3009	1	of	of	IN
cord-006860-a3b8hyyr	3009	2	Medicine	Medicine	NNP
cord-006860-a3b8hyyr	3009	3	,	,	,
cord-006860-a3b8hyyr	3009	4	University	University	NNP
cord-006860-a3b8hyyr	3009	5	Hospital	Hospital	NNP
cord-006860-a3b8hyyr	3009	6	Benjamin	Benjamin	NNP
cord-006860-a3b8hyyr	3009	7	Franklin	Franklin	NNP
cord-006860-a3b8hyyr	3009	8	,	,	,
cord-006860-a3b8hyyr	3009	9	Free	Free	NNP
cord-006860-a3b8hyyr	3009	10	University	University	NNP
cord-006860-a3b8hyyr	3009	11	of	of	IN
cord-006860-a3b8hyyr	3009	12	Berlin	Berlin	NNP
cord-006860-a3b8hyyr	3009	13	,	,	,
cord-006860-a3b8hyyr	3009	14	Dept	Dept	NNP
cord-006860-a3b8hyyr	3009	15	.	.	NNP
cord-006860-a3b8hyyr	3009	16	of	of	IN
cord-006860-a3b8hyyr	3009	17	Medicine	Medicine	NNP
cord-006860-a3b8hyyr	3009	18	and	and	CC
cord-006860-a3b8hyyr	3009	19	Dept	Dept	NNP
cord-006860-a3b8hyyr	3009	20	.	.	NNP
cord-006860-a3b8hyyr	3009	21	of	of	IN
cord-006860-a3b8hyyr	3009	22	Surgery	surgery	NN
cord-006860-a3b8hyyr	3009	23	,	,	,
cord-006860-a3b8hyyr	3009	24	Heinrich	Heinrich	NNP
cord-006860-a3b8hyyr	3009	25	-	-	HYPH
cord-006860-a3b8hyyr	3009	26	Heine	Heine	NNP
cord-006860-a3b8hyyr	3009	27	:	:	:
cord-006860-a3b8hyyr	3009	28	University	University	NNP
cord-006860-a3b8hyyr	3009	29	Dusseldod	Dusseldod	NNP
cord-006860-a3b8hyyr	3010	1	After	after	IN
cord-006860-a3b8hyyr	3010	2	standardized	standardized	JJ
cord-006860-a3b8hyyr	3010	3	training	training	NN
cord-006860-a3b8hyyr	3010	4	in	in	IN
cord-006860-a3b8hyyr	3010	5	home	home	NN
cord-006860-a3b8hyyr	3010	6	prothrombine	prothrombine	NN
cord-006860-a3b8hyyr	3010	7	estimation	estimation	NN
cord-006860-a3b8hyyr	3010	8	using	use	VBG
cord-006860-a3b8hyyr	3010	9	the	the	DT
cord-006860-a3b8hyyr	3010	10	CoaguChek	CoaguChek	NNP
cord-006860-a3b8hyyr	3010	11	system	system	NN
cord-006860-a3b8hyyr	3010	12	,	,	,
cord-006860-a3b8hyyr	3010	13	150	150	CD
cord-006860-a3b8hyyr	3010	14	consecutive	consecutive	JJ
cord-006860-a3b8hyyr	3010	15	patients	patient	NNS
cord-006860-a3b8hyyr	3010	16	(	(	-LRB-
cord-006860-a3b8hyyr	3010	17	p	p	NN
cord-006860-a3b8hyyr	3010	18	)	)	-RRB-
cord-006860-a3b8hyyr	3010	19	who	who	WP
cord-006860-a3b8hyyr	3010	20	had	have	VBD
cord-006860-a3b8hyyr	3010	21	St.	St.	NNP
cord-006860-a3b8hyyr	3010	22	Jude	Jude	NNP
cord-006860-a3b8hyyr	3010	23	Medical	Medical	NNP
cord-006860-a3b8hyyr	3010	24	aortic	aortic	JJ
cord-006860-a3b8hyyr	3010	25	or	or	CC
cord-006860-a3b8hyyr	3010	26	mitral	mitral	JJ
cord-006860-a3b8hyyr	3010	27	valve	valve	NN
cord-006860-a3b8hyyr	3010	28	implantation	implantation	NN
cord-006860-a3b8hyyr	3010	29	were	be	VBD
cord-006860-a3b8hyyr	3010	30	allocated	allocate	VBN
cord-006860-a3b8hyyr	3010	31	to	to	IN
cord-006860-a3b8hyyr	3010	32	two	two	CD
cord-006860-a3b8hyyr	3010	33	random	random	JJ
cord-006860-a3b8hyyr	3010	34	arms	arm	NNS
cord-006860-a3b8hyyr	3010	35	;	;	:
cord-006860-a3b8hyyr	3010	36	75	75	CD
cord-006860-a3b8hyyr	3010	37	p	p	NN
cord-006860-a3b8hyyr	3010	38	were	be	VBD
cord-006860-a3b8hyyr	3010	39	asked	ask	VBN
cord-006860-a3b8hyyr	3010	40	to	to	TO
cord-006860-a3b8hyyr	3010	41	control	control	VB
cord-006860-a3b8hyyr	3010	42	the	the	DT
cord-006860-a3b8hyyr	3010	43	INR	INR	NNP
cord-006860-a3b8hyyr	3010	44	themselves	-PRON-	PRP
cord-006860-a3b8hyyr	3010	45	every	every	DT
cord-006860-a3b8hyyr	3010	46	third	third	JJ
cord-006860-a3b8hyyr	3010	47	day	day	NN
cord-006860-a3b8hyyr	3010	48	.	.	.
cord-006860-a3b8hyyr	3011	1	In	in	IN
cord-006860-a3b8hyyr	3011	2	the	the	DT
cord-006860-a3b8hyyr	3011	3	remaining	remain	VBG
cord-006860-a3b8hyyr	3011	4	75	75	CD
cord-006860-a3b8hyyr	3011	5	p	p	NN
cord-006860-a3b8hyyr	3011	6	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3011	7	was	be	VBD
cord-006860-a3b8hyyr	3011	8	managed	manage	VBN
cord-006860-a3b8hyyr	3011	9	by	by	IN
cord-006860-a3b8hyyr	3011	10	the	the	DT
cord-006860-a3b8hyyr	3011	11	home	home	NN
cord-006860-a3b8hyyr	3011	12	physician	physician	NN
cord-006860-a3b8hyyr	3011	13	without	without	IN
cord-006860-a3b8hyyr	3011	14	recommending	recommend	VBG
cord-006860-a3b8hyyr	3011	15	an	an	DT
cord-006860-a3b8hyyr	3011	16	interval	interval	NN
cord-006860-a3b8hyyr	3011	17	for	for	IN
cord-006860-a3b8hyyr	3011	18	these	these	DT
cord-006860-a3b8hyyr	3011	19	controls	control	NNS
cord-006860-a3b8hyyr	3011	20	.	.	.
cord-006860-a3b8hyyr	3012	1	All	all	DT
cord-006860-a3b8hyyr	3012	2	150	150	CD
cord-006860-a3b8hyyr	3012	3	p	p	NNS
cord-006860-a3b8hyyr	3012	4	were	be	VBD
cord-006860-a3b8hyyr	3012	5	monitored	monitor	VBN
cord-006860-a3b8hyyr	3012	6	during	during	IN
cord-006860-a3b8hyyr	3012	7	the	the	DT
cord-006860-a3b8hyyr	3012	8	education	education	NN
cord-006860-a3b8hyyr	3012	9	period	period	NN
cord-006860-a3b8hyyr	3012	10	to	to	IN
cord-006860-a3b8hyyr	3012	11	a	a	DT
cord-006860-a3b8hyyr	3012	12	target	target	NN
cord-006860-a3b8hyyr	3012	13	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	3012	14	range	range	NN
cord-006860-a3b8hyyr	3012	15	of	of	IN
cord-006860-a3b8hyyr	3012	16	INR	INR	NNP
cord-006860-a3b8hyyr	3012	17	3.5	3.5	CD
cord-006860-a3b8hyyr	3012	18	-	-	SYM
cord-006860-a3b8hyyr	3012	19	4.0	4.0	CD
cord-006860-a3b8hyyr	3012	20	.	.	.
cord-006860-a3b8hyyr	3013	1	P	p	NN
cord-006860-a3b8hyyr	3013	2	were	be	VBD
cord-006860-a3b8hyyr	3013	3	asked	ask	VBN
cord-006860-a3b8hyyr	3013	4	to	to	TO
cord-006860-a3b8hyyr	3013	5	contact	contact	VB
cord-006860-a3b8hyyr	3013	6	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3013	7	home	home	NN
cord-006860-a3b8hyyr	3013	8	physician	physician	NN
cord-006860-a3b8hyyr	3013	9	immediately	immediately	RB
cord-006860-a3b8hyyr	3013	10	if	if	IN
cord-006860-a3b8hyyr	3013	11	the	the	DT
cord-006860-a3b8hyyr	3013	12	INR	INR	NNP
cord-006860-a3b8hyyr	3013	13	was	be	VBD
cord-006860-a3b8hyyr	3013	14	measured	measure	VBN
cord-006860-a3b8hyyr	3013	15	0.5	0.5	CD
cord-006860-a3b8hyyr	3013	16	below	below	RB
cord-006860-a3b8hyyr	3013	17	or	or	CC
cord-006860-a3b8hyyr	3013	18	above	above	IN
cord-006860-a3b8hyyr	3013	19	the	the	DT
cord-006860-a3b8hyyr	3013	20	target	target	NN
cord-006860-a3b8hyyr	3013	21	range	range	NN
cord-006860-a3b8hyyr	3013	22	(	(	-LRB-
cord-006860-a3b8hyyr	3013	23	INR	INR	NNP
cord-006860-a3b8hyyr	3013	24	-	-	HYPH
cord-006860-a3b8hyyr	3013	25	corrider	corrider	NNP
cord-006860-a3b8hyyr	3013	26	3.0	3.0	CD
cord-006860-a3b8hyyr	3013	27	-	-	HYPH
cord-006860-a3b8hyyr	3013	28	4.5	4.5	CD
cord-006860-a3b8hyyr	3013	29	)	)	-RRB-
cord-006860-a3b8hyyr	3013	30	.	.	.
cord-006860-a3b8hyyr	3014	1	All	all	DT
cord-006860-a3b8hyyr	3014	2	p	p	NN
cord-006860-a3b8hyyr	3014	3	had	have	VBD
cord-006860-a3b8hyyr	3014	4	out	out	IN
cord-006860-a3b8hyyr	3014	5	-	-	HYPH
cord-006860-a3b8hyyr	3014	6	patient	patient	NN
cord-006860-a3b8hyyr	3014	7	re	re	NNS
cord-006860-a3b8hyyr	3014	8	-	-	NNS
cord-006860-a3b8hyyr	3014	9	examinations	examination	NNS
cord-006860-a3b8hyyr	3014	10	every	every	DT
cord-006860-a3b8hyyr	3014	11	three	three	CD
cord-006860-a3b8hyyr	3014	12	months	month	NNS
cord-006860-a3b8hyyr	3014	13	.	.	.
cord-006860-a3b8hyyr	3015	1	Thrombotic	Thrombotic	NNP
cord-006860-a3b8hyyr	3015	2	,	,	,
cord-006860-a3b8hyyr	3015	3	thromboembelic	thromboembelic	JJ
cord-006860-a3b8hyyr	3015	4	and	and	CC
cord-006860-a3b8hyyr	3015	5	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	3015	6	complications	complication	NNS
cord-006860-a3b8hyyr	3015	7	were	be	VBD
cord-006860-a3b8hyyr	3015	8	documented	document	VBN
cord-006860-a3b8hyyr	3015	9	by	by	IN
cord-006860-a3b8hyyr	3015	10	the	the	DT
cord-006860-a3b8hyyr	3015	11	p	p	NN
cord-006860-a3b8hyyr	3015	12	using	use	VBG
cord-006860-a3b8hyyr	3015	13	special	special	JJ
cord-006860-a3b8hyyr	3015	14	documentation	documentation	NN
cord-006860-a3b8hyyr	3015	15	cards	card	NNS
cord-006860-a3b8hyyr	3015	16	.	.	.
cord-006860-a3b8hyyr	3016	1	The	the	DT
cord-006860-a3b8hyyr	3016	2	following	follow	VBG
cord-006860-a3b8hyyr	3016	3	findings	finding	NNS
cord-006860-a3b8hyyr	3016	4	were	be	VBD
cord-006860-a3b8hyyr	3016	5	documented	document	VBN
cord-006860-a3b8hyyr	3016	6	during	during	IN
cord-006860-a3b8hyyr	3016	7	the	the	DT
cord-006860-a3b8hyyr	3016	8	follow	follow	NN
cord-006860-a3b8hyyr	3016	9	-	-	HYPH
cord-006860-a3b8hyyr	3016	10	up	up	NN
cord-006860-a3b8hyyr	3016	11	period	period	NN
cord-006860-a3b8hyyr	3016	12	:	:	:
cord-006860-a3b8hyyr	3016	13	4.49	4.49	CD
cord-006860-a3b8hyyr	3016	14	0.9	0.9	CD
cord-006860-a3b8hyyr	3016	15	0	0	CD
cord-006860-a3b8hyyr	3017	1	The	the	DT
cord-006860-a3b8hyyr	3017	2	results	result	NNS
cord-006860-a3b8hyyr	3017	3	of	of	IN
cord-006860-a3b8hyyr	3017	4	this	this	DT
cord-006860-a3b8hyyr	3017	5	randomized	randomized	JJ
cord-006860-a3b8hyyr	3017	6	study	study	NN
cord-006860-a3b8hyyr	3017	7	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	3017	8	a	a	DT
cord-006860-a3b8hyyr	3017	9	significant	significant	JJ
cord-006860-a3b8hyyr	3017	10	improvement	improvement	NN
cord-006860-a3b8hyyr	3017	11	in	in	IN
cord-006860-a3b8hyyr	3017	12	the	the	DT
cord-006860-a3b8hyyr	3017	13	management	management	NN
cord-006860-a3b8hyyr	3017	14	of	of	IN
cord-006860-a3b8hyyr	3017	15	oral	oral	JJ
cord-006860-a3b8hyyr	3017	16	anticeagulation	anticeagulation	NN
cord-006860-a3b8hyyr	3017	17	by	by	IN
cord-006860-a3b8hyyr	3017	18	home	home	NN
cord-006860-a3b8hyyr	3017	19	prothrombine	prothrombine	NN
cord-006860-a3b8hyyr	3017	20	estimation	estimation	NN
cord-006860-a3b8hyyr	3017	21	.	.	.
cord-006860-a3b8hyyr	3018	1	Significant	significant	JJ
cord-006860-a3b8hyyr	3018	2	(	(	-LRB-
cord-006860-a3b8hyyr	3018	3	p<0.001	p<0.001	JJ
cord-006860-a3b8hyyr	3018	4	)	)	-RRB-
cord-006860-a3b8hyyr	3018	5	more	more	JJR
cord-006860-a3b8hyyr	3018	6	INR	INR	NNP
cord-006860-a3b8hyyr	3018	7	measurements	measurement	NNS
cord-006860-a3b8hyyr	3018	8	were	be	VBD
cord-006860-a3b8hyyr	3018	9	found	find	VBN
cord-006860-a3b8hyyr	3018	10	inside	inside	IN
cord-006860-a3b8hyyr	3018	11	the	the	DT
cord-006860-a3b8hyyr	3018	12	target	target	NN
cord-006860-a3b8hyyr	3018	13	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	3018	14	range	range	NN
cord-006860-a3b8hyyr	3018	15	.	.	.
cord-006860-a3b8hyyr	3019	1	Moreover	moreover	RB
cord-006860-a3b8hyyr	3019	2	.	.	.
cord-006860-a3b8hyyr	3020	1	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3020	2	and	and	CC
cord-006860-a3b8hyyr	3020	3	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	3020	4	complications	complication	NNS
cord-006860-a3b8hyyr	3020	5	could	could	MD
cord-006860-a3b8hyyr	3020	6	be	be	VB
cord-006860-a3b8hyyr	3020	7	reduced	reduce	VBN
cord-006860-a3b8hyyr	3021	1	(	(	-LRB-
cord-006860-a3b8hyyr	3021	2	p	p	NN
cord-006860-a3b8hyyr	3021	3	=	=	SYM
cord-006860-a3b8hyyr	3021	4	0.038	0.038	CD
cord-006860-a3b8hyyr	3021	5	)	)	-RRB-
cord-006860-a3b8hyyr	3021	6	in	in	IN
cord-006860-a3b8hyyr	3021	7	the	the	DT
cord-006860-a3b8hyyr	3021	8	study	study	NN
cord-006860-a3b8hyyr	3021	9	group	group	NN
cord-006860-a3b8hyyr	3021	10	with	with	IN
cord-006860-a3b8hyyr	3021	11	home	home	NN
cord-006860-a3b8hyyr	3021	12	prothrombine	prothrombine	NN
cord-006860-a3b8hyyr	3021	13	estimation	estimation	NN
cord-006860-a3b8hyyr	3021	14	.	.	.
cord-006860-a3b8hyyr	3022	1	Life	life	NN
cord-006860-a3b8hyyr	3022	2	-	-	HYPH
cord-006860-a3b8hyyr	3022	3	threatening	threaten	VBG
cord-006860-a3b8hyyr	3022	4	thromboembolic	thromboembolic	NN
cord-006860-a3b8hyyr	3022	5	and	and	CC
cord-006860-a3b8hyyr	3022	6	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	3022	7	complications	complication	NNS
cord-006860-a3b8hyyr	3022	8	were	be	VBD
cord-006860-a3b8hyyr	3022	9	not	not	RB
cord-006860-a3b8hyyr	3022	10	observed	observe	VBN
cord-006860-a3b8hyyr	3022	11	in	in	IN
cord-006860-a3b8hyyr	3022	12	p	p	NN
cord-006860-a3b8hyyr	3022	13	who	who	WP
cord-006860-a3b8hyyr	3022	14	were	be	VBD
cord-006860-a3b8hyyr	3022	15	on	on	IN
cord-006860-a3b8hyyr	3022	16	home	home	NN
cord-006860-a3b8hyyr	3022	17	prothrembine	prothrembine	NN
cord-006860-a3b8hyyr	3022	18	estimation	estimation	NN
cord-006860-a3b8hyyr	3022	19	,	,	,
cord-006860-a3b8hyyr	3022	20	while	while	IN
cord-006860-a3b8hyyr	3022	21	three	three	CD
cord-006860-a3b8hyyr	3022	22	such	such	JJ
cord-006860-a3b8hyyr	3022	23	events	event	NNS
cord-006860-a3b8hyyr	3022	24	(	(	-LRB-
cord-006860-a3b8hyyr	3022	25	2.72	2.72	CD
cord-006860-a3b8hyyr	3022	26	%	%	NN
cord-006860-a3b8hyyr	3022	27	/year	/year	.
cord-006860-a3b8hyyr	3022	28	)	)	-RRB-
cord-006860-a3b8hyyr	3022	29	were	be	VBD
cord-006860-a3b8hyyr	3022	30	documented	document	VBN
cord-006860-a3b8hyyr	3022	31	in	in	IN
cord-006860-a3b8hyyr	3022	32	group	group	NN
cord-006860-a3b8hyyr	3022	33	A.	a.	NN
cord-006860-a3b8hyyr	3022	34	Local	local	JJ
cord-006860-a3b8hyyr	3022	35	vascular	vascular	JJ
cord-006860-a3b8hyyr	3022	36	injury	injury	NN
cord-006860-a3b8hyyr	3022	37	following	follow	VBG
cord-006860-a3b8hyyr	3022	38	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	3022	39	exposes	expose	VBZ
cord-006860-a3b8hyyr	3022	40	circulating	circulate	VBG
cord-006860-a3b8hyyr	3022	41	platelets	platelet	NNS
cord-006860-a3b8hyyr	3022	42	to	to	IN
cord-006860-a3b8hyyr	3022	43	prodmmbogenic	prodmmbogenic	JJ
cord-006860-a3b8hyyr	3022	44	stimuli	stimulus	NNS
cord-006860-a3b8hyyr	3022	45	.	.	.
cord-006860-a3b8hyyr	3023	1	By	by	IN
cord-006860-a3b8hyyr	3023	2	binding	bind	VBG
cord-006860-a3b8hyyr	3023	3	to	to	IN
cord-006860-a3b8hyyr	3023	4	platelet	platelet	NN
cord-006860-a3b8hyyr	3023	5	GP	gp	NN
cord-006860-a3b8hyyr	3023	6	IIbllIIa	iiblliia	JJ
cord-006860-a3b8hyyr	3023	7	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3023	8	crosslinks	crosslink	NNS
cord-006860-a3b8hyyr	3023	9	platelets	platelet	NNS
cord-006860-a3b8hyyr	3023	10	,	,	,
cord-006860-a3b8hyyr	3023	11	which	which	WDT
cord-006860-a3b8hyyr	3023	12	represents	represent	VBZ
cord-006860-a3b8hyyr	3023	13	the	the	DT
cord-006860-a3b8hyyr	3023	14	final	final	JJ
cord-006860-a3b8hyyr	3023	15	common	common	JJ
cord-006860-a3b8hyyr	3023	16	pathway	pathway	NN
cord-006860-a3b8hyyr	3023	17	of	of	IN
cord-006860-a3b8hyyr	3023	18	platelet	platelet	NN
cord-006860-a3b8hyyr	3023	19	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3023	20	.	.	.
cord-006860-a3b8hyyr	3024	1	Fradafiban	Fradafiban	NNP
cord-006860-a3b8hyyr	3024	2	(	(	-LRB-
cord-006860-a3b8hyyr	3024	3	BIBU52ZW	BIBU52ZW	NNP
cord-006860-a3b8hyyr	3024	4	)	)	-RRB-
cord-006860-a3b8hyyr	3024	5	is	be	VBZ
cord-006860-a3b8hyyr	3024	6	a	a	DT
cord-006860-a3b8hyyr	3024	7	non	non	JJ
cord-006860-a3b8hyyr	3024	8	-	-	JJ
cord-006860-a3b8hyyr	3024	9	peptide	peptide	JJ
cord-006860-a3b8hyyr	3024	10	compound	compound	NN
cord-006860-a3b8hyyr	3024	11	with	with	IN
cord-006860-a3b8hyyr	3024	12	effective	effective	JJ
cord-006860-a3b8hyyr	3024	13	,	,	,
cord-006860-a3b8hyyr	3024	14	reversible	reversible	JJ
cord-006860-a3b8hyyr	3024	15	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	3024	16	effects	effect	NNS
cord-006860-a3b8hyyr	3024	17	on	on	IN
cord-006860-a3b8hyyr	3024	18	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3024	19	binding	bind	VBG
cord-006860-a3b8hyyr	3024	20	to	to	IN
cord-006860-a3b8hyyr	3024	21	GP	GP	NNP
cord-006860-a3b8hyyr	3024	22	IIb	IIb	NNP
cord-006860-a3b8hyyr	3024	23	/	/	SYM
cord-006860-a3b8hyyr	3024	24	II	II	NNP
cord-006860-a3b8hyyr	3024	25	/	/	,
cord-006860-a3b8hyyr	3024	26	a	a	DT
cord-006860-a3b8hyyr	3024	27	on	on	IN
cord-006860-a3b8hyyr	3024	28	human	human	JJ
cord-006860-a3b8hyyr	3024	29	platelets	platelet	NNS
cord-006860-a3b8hyyr	3024	30	.	.	.
cord-006860-a3b8hyyr	3025	1	In	in	IN
cord-006860-a3b8hyyr	3025	2	the	the	DT
cord-006860-a3b8hyyr	3025	3	first	first	JJ
cord-006860-a3b8hyyr	3025	4	double	double	RB
cord-006860-a3b8hyyr	3025	5	-	-	HYPH
cord-006860-a3b8hyyr	3025	6	blinded	blinded	JJ
cord-006860-a3b8hyyr	3025	7	,	,	,
cord-006860-a3b8hyyr	3025	8	prospective	prospective	JJ
cord-006860-a3b8hyyr	3025	9	phase	phase	NN
cord-006860-a3b8hyyr	3025	10	II	ii	CD
cord-006860-a3b8hyyr	3025	11	study	study	NN
cord-006860-a3b8hyyr	3025	12	three	three	CD
cord-006860-a3b8hyyr	3025	13	escalating	escalate	VBG
cord-006860-a3b8hyyr	3025	14	doses	dose	NNS
cord-006860-a3b8hyyr	3025	15	of	of	IN
cord-006860-a3b8hyyr	3025	16	BIBU52ZW	BIBU52ZW	NNP
cord-006860-a3b8hyyr	3025	17	as	as	IN
cord-006860-a3b8hyyr	3025	18	a	a	DT
cord-006860-a3b8hyyr	3025	19	continuous	continuous	JJ
cord-006860-a3b8hyyr	3025	20	24	24	CD
cord-006860-a3b8hyyr	3025	21	h	h	NNP
cord-006860-a3b8hyyr	3025	22	-	-	HYPH
cord-006860-a3b8hyyr	3025	23	i.v	i.v	NNP
cord-006860-a3b8hyyr	3025	24	,	,	,
cord-006860-a3b8hyyr	3025	25	infusion	infusion	NN
cord-006860-a3b8hyyr	3025	26	were	be	VBD
cord-006860-a3b8hyyr	3025	27	tested	test	VBN
cord-006860-a3b8hyyr	3025	28	in	in	IN
cord-006860-a3b8hyyr	3025	29	comparison	comparison	NN
cord-006860-a3b8hyyr	3025	30	to	to	IN
cord-006860-a3b8hyyr	3025	31	placebo	placebo	NN
cord-006860-a3b8hyyr	3025	32	in	in	IN
cord-006860-a3b8hyyr	3025	33	65	65	CD
cord-006860-a3b8hyyr	3025	34	patients	patient	NNS
cord-006860-a3b8hyyr	3025	35	with	with	IN
cord-006860-a3b8hyyr	3025	36	stable	stable	JJ
cord-006860-a3b8hyyr	3025	37	angina	angina	JJ
cord-006860-a3b8hyyr	3025	38	pectoris	pectoris	NN
cord-006860-a3b8hyyr	3025	39	undergoing	undergo	VBG
cord-006860-a3b8hyyr	3025	40	elective	elective	JJ
cord-006860-a3b8hyyr	3025	41	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	3025	42	.	.	.
cord-006860-a3b8hyyr	3026	1	The	the	DT
cord-006860-a3b8hyyr	3026	2	mean	mean	JJ
cord-006860-a3b8hyyr	3026	3	receptor	receptor	NN
cord-006860-a3b8hyyr	3026	4	occupancy	occupancy	NN
cord-006860-a3b8hyyr	3026	5	with	with	IN
cord-006860-a3b8hyyr	3026	6	20rag	20rag	NN
cord-006860-a3b8hyyr	3026	7	,	,	,
cord-006860-a3b8hyyr	3026	8	40ms	40ms	CD
cord-006860-a3b8hyyr	3026	9	and	and	CC
cord-006860-a3b8hyyr	3026	10	60ms	60ms	NN
cord-006860-a3b8hyyr	3026	11	per	per	IN
cord-006860-a3b8hyyr	3026	12	hour	hour	NN
cord-006860-a3b8hyyr	3026	13	were	be	VBD
cord-006860-a3b8hyyr	3026	14	71.974	71.974	CD
cord-006860-a3b8hyyr	3026	15	,	,	,
cord-006860-a3b8hyyr	3026	16	84.5	84.5	CD
cord-006860-a3b8hyyr	3026	17	%	%	NN
cord-006860-a3b8hyyr	3026	18	and	and	CC
cord-006860-a3b8hyyr	3026	19	87.9	87.9	CD
cord-006860-a3b8hyyr	3026	20	%	%	NN
cord-006860-a3b8hyyr	3026	21	at	at	IN
cord-006860-a3b8hyyr	3026	22	24	24	CD
cord-006860-a3b8hyyr	3026	23	hours	hour	NNS
cord-006860-a3b8hyyr	3026	24	,	,	,
cord-006860-a3b8hyyr	3026	25	respectively	respectively	RB
cord-006860-a3b8hyyr	3026	26	.	.	.
cord-006860-a3b8hyyr	3027	1	As	as	IN
cord-006860-a3b8hyyr	3027	2	compared	compare	VBN
cord-006860-a3b8hyyr	3027	3	to	to	IN
cord-006860-a3b8hyyr	3027	4	placebo	placebo	NN
cord-006860-a3b8hyyr	3027	5	breeding	breeding	NN
cord-006860-a3b8hyyr	3027	6	time	time	NN
cord-006860-a3b8hyyr	3027	7	was	be	VBD
cord-006860-a3b8hyyr	3027	8	significantly	significantly	RB
cord-006860-a3b8hyyr	3027	9	prolonged	prolong	VBN
cord-006860-a3b8hyyr	3027	10	(	(	-LRB-
cord-006860-a3b8hyyr	3027	11	7	7	CD
cord-006860-a3b8hyyr	3027	12	vs	vs	IN
cord-006860-a3b8hyyr	3027	13	20rain	20rain	CD
cord-006860-a3b8hyyr	3027	14	)	)	-RRB-
cord-006860-a3b8hyyr	3027	15	during	during	IN
cord-006860-a3b8hyyr	3027	16	fi	fi	NNP
cord-006860-a3b8hyyr	3027	17	-	-	HYPH
cord-006860-a3b8hyyr	3027	18	adaIiban	adaIiban	NNP
cord-006860-a3b8hyyr	3027	19	infusion	infusion	NN
cord-006860-a3b8hyyr	3027	20	with	with	IN
cord-006860-a3b8hyyr	3027	21	a	a	DT
cord-006860-a3b8hyyr	3027	22	weak	weak	JJ
cord-006860-a3b8hyyr	3027	23	dose	dose	NN
cord-006860-a3b8hyyr	3027	24	-	-	HYPH
cord-006860-a3b8hyyr	3027	25	dependency	dependency	NN
cord-006860-a3b8hyyr	3027	26	.	.	.
cord-006860-a3b8hyyr	3028	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	3028	2	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3028	3	in	in	IN
cord-006860-a3b8hyyr	3028	4	platetet	platetet	JJ
cord-006860-a3b8hyyr	3028	5	rich	rich	JJ
cord-006860-a3b8hyyr	3028	6	plasma	plasma	NN
cord-006860-a3b8hyyr	3028	7	ex	ex	FW
cord-006860-a3b8hyyr	3028	8	vivo	vivo	NN
cord-006860-a3b8hyyr	3028	9	with	with	IN
cord-006860-a3b8hyyr	3028	10	collagen	collagen	NN
cord-006860-a3b8hyyr	3028	11	(	(	-LRB-
cord-006860-a3b8hyyr	3028	12	2.0	2.0	CD
cord-006860-a3b8hyyr	3028	13	and	and	CC
cord-006860-a3b8hyyr	3028	14	4.0	4.0	CD
cord-006860-a3b8hyyr	3028	15	gg	gg	NNP
cord-006860-a3b8hyyr	3028	16	/	/	SYM
cord-006860-a3b8hyyr	3028	17	ml	ml	NNP
cord-006860-a3b8hyyr	3028	18	)	)	-RRB-
cord-006860-a3b8hyyr	3028	19	,	,	.
cord-006860-a3b8hyyr	3029	1	ADP	ADP	NNP
cord-006860-a3b8hyyr	3029	2	(	(	-LRB-
cord-006860-a3b8hyyr	3029	3	2.5	2.5	CD
cord-006860-a3b8hyyr	3029	4	and	and	CC
cord-006860-a3b8hyyr	3029	5	5.0	5.0	CD
cord-006860-a3b8hyyr	3029	6	gmol	gmol	NN
cord-006860-a3b8hyyr	3029	7	/	/	SYM
cord-006860-a3b8hyyr	3029	8	ml	ml	NN
cord-006860-a3b8hyyr	3029	9	)	)	-RRB-
cord-006860-a3b8hyyr	3029	10	or	or	CC
cord-006860-a3b8hyyr	3030	1	Ca	Ca	NNP
cord-006860-a3b8hyyr	3030	2	-	-	HYPH
cord-006860-a3b8hyyr	3030	3	ionophor	ionophor	NNP
cord-006860-a3b8hyyr	3031	1	A	a	DT
cord-006860-a3b8hyyr	3031	2	23187	23187	CD
cord-006860-a3b8hyyr	3031	3	(	(	-LRB-
cord-006860-a3b8hyyr	3031	4	2.5	2.5	CD
cord-006860-a3b8hyyr	3031	5	and	and	CC
cord-006860-a3b8hyyr	3031	6	5.0gg	5.0gg	CD
cord-006860-a3b8hyyr	3031	7	/	/	SYM
cord-006860-a3b8hyyr	3031	8	ml	ml	NN
cord-006860-a3b8hyyr	3031	9	)	)	-RRB-
cord-006860-a3b8hyyr	3031	10	was	be	VBD
cord-006860-a3b8hyyr	3031	11	significantly	significantly	RB
cord-006860-a3b8hyyr	3031	12	and	and	CC
cord-006860-a3b8hyyr	3031	13	dose	dose	RB
cord-006860-a3b8hyyr	3031	14	-	-	HYPH
cord-006860-a3b8hyyr	3031	15	dependently	dependently	RB
cord-006860-a3b8hyyr	3031	16	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	3031	17	as	as	IN
cord-006860-a3b8hyyr	3031	18	compared	compare	VBN
cord-006860-a3b8hyyr	3031	19	to	to	IN
cord-006860-a3b8hyyr	3031	20	placebo	placebo	NN
cord-006860-a3b8hyyr	3031	21	.	.	.
cord-006860-a3b8hyyr	3032	1	Using	use	VBG
cord-006860-a3b8hyyr	3032	2	the	the	DT
cord-006860-a3b8hyyr	3032	3	two	two	CD
cord-006860-a3b8hyyr	3032	4	upper	upper	JJ
cord-006860-a3b8hyyr	3032	5	doses	dose	NNS
cord-006860-a3b8hyyr	3032	6	of	of	IN
cord-006860-a3b8hyyr	3032	7	fradafiban	fradafiban	NNP
cord-006860-a3b8hyyr	3032	8	,	,	,
cord-006860-a3b8hyyr	3032	9	we	-PRON-	PRP
cord-006860-a3b8hyyr	3032	10	observed	observe	VBD
cord-006860-a3b8hyyr	3032	11	major	major	JJ
cord-006860-a3b8hyyr	3032	12	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3032	13	complications	complication	NNS
cord-006860-a3b8hyyr	3032	14	in	in	IN
cord-006860-a3b8hyyr	3032	15	8	8	CD
cord-006860-a3b8hyyr	3032	16	patients	patient	NNS
cord-006860-a3b8hyyr	3032	17	requiring	require	VBG
cord-006860-a3b8hyyr	3032	18	blood	blood	NN
cord-006860-a3b8hyyr	3032	19	transfusions	transfusion	NNS
cord-006860-a3b8hyyr	3032	20	or	or	CC
cord-006860-a3b8hyyr	3032	21	vascular	vascular	JJ
cord-006860-a3b8hyyr	3032	22	surreal	surreal	JJ
cord-006860-a3b8hyyr	3032	23	repair	repair	NN
cord-006860-a3b8hyyr	3032	24	.	.	.
cord-006860-a3b8hyyr	3033	1	In	in	IN
cord-006860-a3b8hyyr	3033	2	these	these	DT
cord-006860-a3b8hyyr	3033	3	patients	patient	NNS
cord-006860-a3b8hyyr	3033	4	,	,	,
cord-006860-a3b8hyyr	3033	5	too	too	RB
cord-006860-a3b8hyyr	3033	6	,	,	,
cord-006860-a3b8hyyr	3033	7	maximal	maximal	JJ
cord-006860-a3b8hyyr	3033	8	antiplatelet	antiplatelet	NN
cord-006860-a3b8hyyr	3033	9	effects	effect	NNS
cord-006860-a3b8hyyr	3033	10	could	could	MD
cord-006860-a3b8hyyr	3033	11	be	be	VB
cord-006860-a3b8hyyr	3033	12	documented	document	VBN
cord-006860-a3b8hyyr	3033	13	.	.	.
cord-006860-a3b8hyyr	3034	1	These	these	DT
cord-006860-a3b8hyyr	3034	2	data	datum	NNS
cord-006860-a3b8hyyr	3034	3	sugest	sugest	VBP
cord-006860-a3b8hyyr	3034	4	that	that	DT
cord-006860-a3b8hyyr	3034	5	BIBU52ZW	BIBU52ZW	NNP
cord-006860-a3b8hyyr	3034	6	is	be	VBZ
cord-006860-a3b8hyyr	3034	7	an	an	DT
cord-006860-a3b8hyyr	3034	8	effective	effective	JJ
cord-006860-a3b8hyyr	3034	9	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3034	10	receptor	receptor	NN
cord-006860-a3b8hyyr	3034	11	antagonist	antagonist	NN
cord-006860-a3b8hyyr	3034	12	in	in	IN
cord-006860-a3b8hyyr	3034	13	patients	patient	NNS
cord-006860-a3b8hyyr	3034	14	.	.	.
cord-006860-a3b8hyyr	3035	1	The	the	DT
cord-006860-a3b8hyyr	3035	2	requirement	requirement	NN
cord-006860-a3b8hyyr	3035	3	of	of	IN
cord-006860-a3b8hyyr	3035	4	ad	ad	FW
cord-006860-a3b8hyyr	3035	5	hoc	hoc	FW
cord-006860-a3b8hyyr	3035	6	receptor	receptor	NN
cord-006860-a3b8hyyr	3035	7	occupancy	occupancy	NN
cord-006860-a3b8hyyr	3035	8	determination	determination	NN
cord-006860-a3b8hyyr	3035	9	or	or	CC
cord-006860-a3b8hyyr	3035	10	platelet	platelet	NN
cord-006860-a3b8hyyr	3035	11	function	function	NN
cord-006860-a3b8hyyr	3035	12	monitoring	monitor	VBG
cord-006860-a3b8hyyr	3035	13	for	for	IN
cord-006860-a3b8hyyr	3035	14	safe	safe	JJ
cord-006860-a3b8hyyr	3035	15	and	and	CC
cord-006860-a3b8hyyr	3035	16	effective	effective	JJ
cord-006860-a3b8hyyr	3035	17	clinical	clinical	JJ
cord-006860-a3b8hyyr	3035	18	use	use	NN
cord-006860-a3b8hyyr	3035	19	should	should	MD
cord-006860-a3b8hyyr	3035	20	be	be	VB
cord-006860-a3b8hyyr	3035	21	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	3035	22	.	.	.
cord-006860-a3b8hyyr	3036	1	In	in	IN
cord-006860-a3b8hyyr	3036	2	a	a	DT
cord-006860-a3b8hyyr	3036	3	placebo	placebo	NN
cord-006860-a3b8hyyr	3036	4	controlled	control	VBN
cord-006860-a3b8hyyr	3036	5	interaction	interaction	NN
cord-006860-a3b8hyyr	3036	6	study	study	NN
cord-006860-a3b8hyyr	3036	7	9	9	CD
cord-006860-a3b8hyyr	3036	8	healthy	healthy	JJ
cord-006860-a3b8hyyr	3036	9	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	3036	10	were	be	VBD
cord-006860-a3b8hyyr	3036	11	randomized	randomize	VBN
cord-006860-a3b8hyyr	3036	12	to	to	TO
cord-006860-a3b8hyyr	3036	13	receive	receive	VB
cord-006860-a3b8hyyr	3036	14	either	either	CC
cord-006860-a3b8hyyr	3036	15	a	a	DT
cord-006860-a3b8hyyr	3036	16	24	24	CD
cord-006860-a3b8hyyr	3036	17	hour	hour	NN
cord-006860-a3b8hyyr	3036	18	infusion	infusion	NN
cord-006860-a3b8hyyr	3036	19	of	of	IN
cord-006860-a3b8hyyr	3036	20	PEG	PEG	NNP
cord-006860-a3b8hyyr	3036	21	-	-	HYPH
cord-006860-a3b8hyyr	3036	22	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3036	23	(	(	-LRB-
cord-006860-a3b8hyyr	3036	24	0.02	0.02	CD
cord-006860-a3b8hyyr	3036	25	mg	mg	NNP
cord-006860-a3b8hyyr	3036	26	/	/	SYM
cord-006860-a3b8hyyr	3036	27	kg	kg	NNP
cord-006860-a3b8hyyr	3036	28	/	/	SYM
cord-006860-a3b8hyyr	3036	29	h	h	NN
cord-006860-a3b8hyyr	3036	30	)	)	-RRB-
cord-006860-a3b8hyyr	3036	31	after	after	IN
cord-006860-a3b8hyyr	3036	32	an	an	DT
cord-006860-a3b8hyyr	3036	33	i.v	i.v	NNP
cord-006860-a3b8hyyr	3036	34	,	,	,
cord-006860-a3b8hyyr	3036	35	bolus	bolus	NN
cord-006860-a3b8hyyr	3036	36	of	of	IN
cord-006860-a3b8hyyr	3036	37	0.2	0.2	CD
cord-006860-a3b8hyyr	3036	38	mg	mg	NNP
cord-006860-a3b8hyyr	3036	39	/	/	SYM
cord-006860-a3b8hyyr	3036	40	kg	kg	NN
cord-006860-a3b8hyyr	3036	41	+	+	CC
cord-006860-a3b8hyyr	3036	42	placebo	placebo	NN
cord-006860-a3b8hyyr	3036	43	,	,	,
cord-006860-a3b8hyyr	3036	44	or	or	CC
cord-006860-a3b8hyyr	3036	45	325	325	CD
cord-006860-a3b8hyyr	3036	46	mg	mg	NN
cord-006860-a3b8hyyr	3036	47	/	/	SYM
cord-006860-a3b8hyyr	3036	48	day	day	NN
cord-006860-a3b8hyyr	3036	49	acetylsalicylic	acetylsalicylic	NN
cord-006860-a3b8hyyr	3036	50	acid	acid	NN
cord-006860-a3b8hyyr	3036	51	(	(	-LRB-
cord-006860-a3b8hyyr	3036	52	ASA	ASA	NNP
cord-006860-a3b8hyyr	3036	53	)	)	-RRB-
cord-006860-a3b8hyyr	3036	54	for	for	IN
cord-006860-a3b8hyyr	3036	55	three	three	CD
cord-006860-a3b8hyyr	3036	56	days	day	NNS
cord-006860-a3b8hyyr	3036	57	followed	follow	VBN
cord-006860-a3b8hyyr	3036	58	by	by	IN
cord-006860-a3b8hyyr	3036	59	a	a	DT
cord-006860-a3b8hyyr	3036	60	placebo	placebo	NN
cord-006860-a3b8hyyr	3036	61	infusion	infusion	NN
cord-006860-a3b8hyyr	3036	62	or	or	CC
cord-006860-a3b8hyyr	3036	63	the	the	DT
cord-006860-a3b8hyyr	3036	64	PEG	PEG	NNP
cord-006860-a3b8hyyr	3036	65	-	-	HYPH
cord-006860-a3b8hyyr	3036	66	Hirudin	hirudin	NN
cord-006860-a3b8hyyr	3036	67	infusion	infusion	NN
cord-006860-a3b8hyyr	3036	68	+	+	CC
cord-006860-a3b8hyyr	3036	69	ASA	ASA	NNP
cord-006860-a3b8hyyr	3036	70	.	.	.
cord-006860-a3b8hyyr	3037	1	Each	each	DT
cord-006860-a3b8hyyr	3037	2	volunteer	volunteer	NN
cord-006860-a3b8hyyr	3037	3	received	receive	VBD
cord-006860-a3b8hyyr	3037	4	all	all	DT
cord-006860-a3b8hyyr	3037	5	three	three	CD
cord-006860-a3b8hyyr	3037	6	treaments	treament	NNS
cord-006860-a3b8hyyr	3037	7	.	.	.
cord-006860-a3b8hyyr	3038	1	There	there	EX
cord-006860-a3b8hyyr	3038	2	was	be	VBD
cord-006860-a3b8hyyr	3038	3	a	a	DT
cord-006860-a3b8hyyr	3038	4	washout	washout	NN
cord-006860-a3b8hyyr	3038	5	period	period	NN
cord-006860-a3b8hyyr	3038	6	of	of	IN
cord-006860-a3b8hyyr	3038	7	at	at	RB
cord-006860-a3b8hyyr	3038	8	least	least	RBS
cord-006860-a3b8hyyr	3038	9	14	14	CD
cord-006860-a3b8hyyr	3038	10	days	day	NNS
cord-006860-a3b8hyyr	3038	11	between	between	IN
cord-006860-a3b8hyyr	3038	12	the	the	DT
cord-006860-a3b8hyyr	3038	13	infusions	infusion	NNS
cord-006860-a3b8hyyr	3038	14	.	.	.
cord-006860-a3b8hyyr	3039	1	At	at	IN
cord-006860-a3b8hyyr	3039	2	short	short	JJ
cord-006860-a3b8hyyr	3039	3	intervals	interval	NNS
cord-006860-a3b8hyyr	3039	4	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	3039	5	,	,	,
cord-006860-a3b8hyyr	3039	6	activated	activate	VBN
cord-006860-a3b8hyyr	3039	7	clotting	clotting	NN
cord-006860-a3b8hyyr	3039	8	time	time	NN
cord-006860-a3b8hyyr	3039	9	(	(	-LRB-
cord-006860-a3b8hyyr	3039	10	ACT	ACT	NNP
cord-006860-a3b8hyyr	3039	11	)	)	-RRB-
cord-006860-a3b8hyyr	3039	12	,	,	,
cord-006860-a3b8hyyr	3039	13	ecadntime	ecadntime	NNP
cord-006860-a3b8hyyr	3039	14	(	(	-LRB-
cord-006860-a3b8hyyr	3039	15	ECT	ECT	NNP
cord-006860-a3b8hyyr	3039	16	)	)	-RRB-
cord-006860-a3b8hyyr	3039	17	,	,	,
cord-006860-a3b8hyyr	3039	18	alia	alia	NN
cord-006860-a3b8hyyr	3039	19	-	-	HYPH
cord-006860-a3b8hyyr	3039	20	activity	activity	NN
cord-006860-a3b8hyyr	3039	21	using	use	VBG
cord-006860-a3b8hyyr	3039	22	the	the	DT
cord-006860-a3b8hyyr	3039	23	chromogenic	chromogenic	NNP
cord-006860-a3b8hyyr	3039	24	substrate	substrate	NN
cord-006860-a3b8hyyr	3039	25	2238	2238	CD
cord-006860-a3b8hyyr	3039	26	,	,	,
cord-006860-a3b8hyyr	3039	27	Collagen	collagen	NN
cord-006860-a3b8hyyr	3039	28	-	-	HYPH
cord-006860-a3b8hyyr	3039	29	induced	induce	VBN
cord-006860-a3b8hyyr	3039	30	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3039	31	,	,	,
cord-006860-a3b8hyyr	3039	32	Platelet	platelet	NN
cord-006860-a3b8hyyr	3039	33	adhesion	adhesion	NN
cord-006860-a3b8hyyr	3039	34	and	and	CC
cord-006860-a3b8hyyr	3039	35	platelet	platelet	NN
cord-006860-a3b8hyyr	3039	36	induced	induce	VBN
cord-006860-a3b8hyyr	3039	37	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3039	38	gene	gene	NN
cord-006860-a3b8hyyr	3039	39	,	,	,
cord-006860-a3b8hyyr	3039	40	ration	ration	NN
cord-006860-a3b8hyyr	3039	41	time	time	NN
cord-006860-a3b8hyyr	3039	42	(	(	-LRB-
cord-006860-a3b8hyyr	3039	43	PITT	PITT	NNP
cord-006860-a3b8hyyr	3039	44	)	)	-RRB-
cord-006860-a3b8hyyr	3039	45	were	be	VBD
cord-006860-a3b8hyyr	3039	46	measured	measure	VBN
cord-006860-a3b8hyyr	3039	47	,	,	,
cord-006860-a3b8hyyr	3039	48	Bleeding	bleed	VBG
cord-006860-a3b8hyyr	3039	49	time	time	NN
cord-006860-a3b8hyyr	3039	50	(	(	-LRB-
cord-006860-a3b8hyyr	3039	51	Simplate	Simplate	NNP
cord-006860-a3b8hyyr	3039	52	)	)	-RRB-
cord-006860-a3b8hyyr	3039	53	was	be	VBD
cord-006860-a3b8hyyr	3039	54	studied	study	VBN
cord-006860-a3b8hyyr	3039	55	before	before	IN
cord-006860-a3b8hyyr	3039	56	drug	drug	NNP
cord-006860-a3b8hyyr	3039	57	administration	administration	NNP
cord-006860-a3b8hyyr	3039	58	,	,	,
cord-006860-a3b8hyyr	3039	59	on	on	IN
cord-006860-a3b8hyyr	3039	60	day	day	NN
cord-006860-a3b8hyyr	3039	61	three	three	CD
cord-006860-a3b8hyyr	3039	62	before	before	IN
cord-006860-a3b8hyyr	3039	63	the	the	DT
cord-006860-a3b8hyyr	3039	64	infusion	infusion	NN
cord-006860-a3b8hyyr	3039	65	and	and	CC
cord-006860-a3b8hyyr	3039	66	6	6	CD
cord-006860-a3b8hyyr	3039	67	hours	hour	NNS
cord-006860-a3b8hyyr	3039	68	after	after	IN
cord-006860-a3b8hyyr	3039	69	start	start	NN
cord-006860-a3b8hyyr	3039	70	of	of	IN
cord-006860-a3b8hyyr	3039	71	the	the	DT
cord-006860-a3b8hyyr	3039	72	Infusion	Infusion	NNP
cord-006860-a3b8hyyr	3039	73	.	.	.
cord-006860-a3b8hyyr	3040	1	The	the	DT
cord-006860-a3b8hyyr	3040	2	Infusion	Infusion	NNP
cord-006860-a3b8hyyr	3040	3	of	of	IN
cord-006860-a3b8hyyr	3040	4	PEG	PEG	NNP
cord-006860-a3b8hyyr	3040	5	-	-	:
cord-006860-a3b8hyyr	3040	6	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3040	7	after	after	IN
cord-006860-a3b8hyyr	3040	8	4	4	CD
cord-006860-a3b8hyyr	3040	9	and	and	CC
cord-006860-a3b8hyyr	3040	10	8	8	CD
cord-006860-a3b8hyyr	3040	11	hours	hour	NNS
cord-006860-a3b8hyyr	3040	12	led	lead	VBD
cord-006860-a3b8hyyr	3040	13	to	to	IN
cord-006860-a3b8hyyr	3040	14	a	a	DT
cord-006860-a3b8hyyr	3040	15	mean	mean	JJ
cord-006860-a3b8hyyr	3040	16	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3040	17	plasma	plasma	NN
cord-006860-a3b8hyyr	3040	18	level	level	NN
cord-006860-a3b8hyyr	3040	19	of	of	IN
cord-006860-a3b8hyyr	3040	20	1.8	1.8	CD
cord-006860-a3b8hyyr	3040	21	pg	pg	NN
cord-006860-a3b8hyyr	3040	22	/	/	SYM
cord-006860-a3b8hyyr	3040	23	ml	ml	NN
cord-006860-a3b8hyyr	3040	24	.	.	.
cord-006860-a3b8hyyr	3041	1	ASA	ASA	NNP
cord-006860-a3b8hyyr	3041	2	markedly	markedly	RB
cord-006860-a3b8hyyr	3041	3	inhibited	inhibit	VBD
cord-006860-a3b8hyyr	3041	4	Collagen	Collagen	NNP
cord-006860-a3b8hyyr	3041	5	induced	induce	VBN
cord-006860-a3b8hyyr	3041	6	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3041	7	as	as	IN
cord-006860-a3b8hyyr	3041	8	expected	expect	VBN
cord-006860-a3b8hyyr	3041	9	.	.	.
cord-006860-a3b8hyyr	3042	1	The	the	DT
cord-006860-a3b8hyyr	3042	2	mean	mean	JJ
cord-006860-a3b8hyyr	3042	3	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3042	4	time	time	NN
cord-006860-a3b8hyyr	3042	5	was	be	VBD
cord-006860-a3b8hyyr	3042	6	prolonged	prolong	VBN
cord-006860-a3b8hyyr	3042	7	under	under	IN
cord-006860-a3b8hyyr	3042	8	the	the	DT
cord-006860-a3b8hyyr	3042	9	influence	influence	NN
cord-006860-a3b8hyyr	3042	10	of	of	IN
cord-006860-a3b8hyyr	3042	11	PEG	peg	NN
cord-006860-a3b8hyyr	3042	12	-	-	:
cord-006860-a3b8hyyr	3042	13	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3042	14	from	from	IN
cord-006860-a3b8hyyr	3042	15	5.2	5.2	CD
cord-006860-a3b8hyyr	3042	16	to	to	IN
cord-006860-a3b8hyyr	3042	17	6.22	6.22	CD
cord-006860-a3b8hyyr	3042	18	min	min	NN
cord-006860-a3b8hyyr	3042	19	,	,	,
cord-006860-a3b8hyyr	3042	20	after	after	IN
cord-006860-a3b8hyyr	3042	21	ASA	ASA	NNP
cord-006860-a3b8hyyr	3042	22	from	from	IN
cord-006860-a3b8hyyr	3042	23	5.8	5.8	CD
cord-006860-a3b8hyyr	3042	24	-18.2	-18.2	CD
cord-006860-a3b8hyyr	3042	25	min	min	NN
cord-006860-a3b8hyyr	3042	26	and	and	CC
cord-006860-a3b8hyyr	3042	27	after	after	IN
cord-006860-a3b8hyyr	3042	28	the	the	DT
cord-006860-a3b8hyyr	3042	29	combination	combination	NN
cord-006860-a3b8hyyr	3042	30	of	of	IN
cord-006860-a3b8hyyr	3042	31	PEG	PEG	NNP
cord-006860-a3b8hyyr	3042	32	-	-	HYPH
cord-006860-a3b8hyyr	3042	33	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3042	34	+	+	CC
cord-006860-a3b8hyyr	3042	35	ASA	ASA	NNP
cord-006860-a3b8hyyr	3042	36	from	from	IN
cord-006860-a3b8hyyr	3042	37	5.4	5.4	CD
cord-006860-a3b8hyyr	3042	38	-33.7	-33.7	CD
cord-006860-a3b8hyyr	3042	39	min	min	NN
cord-006860-a3b8hyyr	3042	40	.	.	.
cord-006860-a3b8hyyr	3043	1	In	in	IN
cord-006860-a3b8hyyr	3043	2	each	each	DT
cord-006860-a3b8hyyr	3043	3	volunteer	volunteer	NN
cord-006860-a3b8hyyr	3043	4	the	the	DT
cord-006860-a3b8hyyr	3043	5	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	3043	6	time	time	NN
cord-006860-a3b8hyyr	3043	7	was	be	VBD
cord-006860-a3b8hyyr	3043	8	longer	long	JJR
cord-006860-a3b8hyyr	3043	9	under	under	IN
cord-006860-a3b8hyyr	3043	10	the	the	DT
cord-006860-a3b8hyyr	3043	11	combination	combination	NN
cord-006860-a3b8hyyr	3043	12	than	than	IN
cord-006860-a3b8hyyr	3043	13	after	after	IN
cord-006860-a3b8hyyr	3043	14	ASA	ASA	NNP
cord-006860-a3b8hyyr	3043	15	alone	alone	RB
cord-006860-a3b8hyyr	3043	16	.	.	.
cord-006860-a3b8hyyr	3044	1	In	in	IN
cord-006860-a3b8hyyr	3044	2	two	two	CD
cord-006860-a3b8hyyr	3044	3	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	3044	4	receiving	receive	VBG
cord-006860-a3b8hyyr	3044	5	PEG	PEG	NNP
cord-006860-a3b8hyyr	3044	6	-	-	HYPH
cord-006860-a3b8hyyr	3044	7	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3044	8	+	+	CC
cord-006860-a3b8hyyr	3044	9	ASA	ASA	NNP
cord-006860-a3b8hyyr	3044	10	the	the	DT
cord-006860-a3b8hyyr	3044	11	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3044	12	time	time	NN
cord-006860-a3b8hyyr	3044	13	measurement	measurement	NN
cord-006860-a3b8hyyr	3044	14	was	be	VBD
cord-006860-a3b8hyyr	3044	15	stopped	stop	VBN
cord-006860-a3b8hyyr	3044	16	after	after	IN
cord-006860-a3b8hyyr	3044	17	60	60	CD
cord-006860-a3b8hyyr	3044	18	rain	rain	NN
cord-006860-a3b8hyyr	3044	19	.	.	.
cord-006860-a3b8hyyr	3045	1	None	none	NN
cord-006860-a3b8hyyr	3045	2	of	of	IN
cord-006860-a3b8hyyr	3045	3	the	the	DT
cord-006860-a3b8hyyr	3045	4	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3045	5	parameters	parameter	NNS
cord-006860-a3b8hyyr	3045	6	or	or	CC
cord-006860-a3b8hyyr	3045	7	platelet	platelet	NN
cord-006860-a3b8hyyr	3045	8	function	function	NN
cord-006860-a3b8hyyr	3045	9	tests	test	NNS
cord-006860-a3b8hyyr	3045	10	correlated	correlate	VBN
cord-006860-a3b8hyyr	3045	11	with	with	IN
cord-006860-a3b8hyyr	3045	12	the	the	DT
cord-006860-a3b8hyyr	3045	13	prolongation	prolongation	NN
cord-006860-a3b8hyyr	3045	14	of	of	IN
cord-006860-a3b8hyyr	3045	15	the	the	DT
cord-006860-a3b8hyyr	3045	16	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	3045	17	time	time	NN
cord-006860-a3b8hyyr	3045	18	.	.	.
cord-006860-a3b8hyyr	3046	1	However	however	RB
cord-006860-a3b8hyyr	3046	2	the	the	DT
cord-006860-a3b8hyyr	3046	3	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	3046	4	time	time	NN
cord-006860-a3b8hyyr	3046	5	was	be	VBD
cord-006860-a3b8hyyr	3046	6	excessively	excessively	RB
cord-006860-a3b8hyyr	3046	7	prolonged	prolong	VBN
cord-006860-a3b8hyyr	3046	8	in	in	IN
cord-006860-a3b8hyyr	3046	9	those	those	DT
cord-006860-a3b8hyyr	3046	10	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	3046	11	who	who	WP
cord-006860-a3b8hyyr	3046	12	had	have	VBD
cord-006860-a3b8hyyr	3046	13	a	a	DT
cord-006860-a3b8hyyr	3046	14	marked	marked	JJ
cord-006860-a3b8hyyr	3046	15	prolongation	prolongation	NN
cord-006860-a3b8hyyr	3046	16	under	under	IN
cord-006860-a3b8hyyr	3046	17	ASA	ASA	NNP
cord-006860-a3b8hyyr	3046	18	alone	alone	RB
cord-006860-a3b8hyyr	3046	19	.	.	.
cord-006860-a3b8hyyr	3047	1	The	the	DT
cord-006860-a3b8hyyr	3047	2	combination	combination	NN
cord-006860-a3b8hyyr	3047	3	of	of	IN
cord-006860-a3b8hyyr	3047	4	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3047	5	at	at	IN
cord-006860-a3b8hyyr	3047	6	a	a	DT
cord-006860-a3b8hyyr	3047	7	higher	high	JJR
cord-006860-a3b8hyyr	3047	8	dosage	dosage	NN
cord-006860-a3b8hyyr	3047	9	with	with	IN
cord-006860-a3b8hyyr	3047	10	ASA	ASA	NNP
cord-006860-a3b8hyyr	3047	11	probably	probably	RB
cord-006860-a3b8hyyr	3047	12	is	be	VBZ
cord-006860-a3b8hyyr	3047	13	associated	associate	VBN
cord-006860-a3b8hyyr	3047	14	with	with	IN
cord-006860-a3b8hyyr	3047	15	a	a	DT
cord-006860-a3b8hyyr	3047	16	relative	relative	JJ
cord-006860-a3b8hyyr	3047	17	high	high	JJ
cord-006860-a3b8hyyr	3047	18	risk	risk	NN
cord-006860-a3b8hyyr	3047	19	of	of	IN
cord-006860-a3b8hyyr	3047	20	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3047	21	.	.	.
cord-006860-a3b8hyyr	3048	1	Either	either	CC
cord-006860-a3b8hyyr	3048	2	the	the	DT
cord-006860-a3b8hyyr	3048	3	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3048	4	dosage	dosage	NN
cord-006860-a3b8hyyr	3048	5	should	should	MD
cord-006860-a3b8hyyr	3048	6	be	be	VB
cord-006860-a3b8hyyr	3048	7	reduced	reduce	VBN
cord-006860-a3b8hyyr	3048	8	if	if	IN
cord-006860-a3b8hyyr	3048	9	the	the	DT
cord-006860-a3b8hyyr	3048	10	combination	combination	NN
cord-006860-a3b8hyyr	3048	11	seems	seem	VBZ
cord-006860-a3b8hyyr	3048	12	feasabie	feasabie	NN
cord-006860-a3b8hyyr	3048	13	or	or	CC
cord-006860-a3b8hyyr	3048	14	ASA	ASA	NNP
cord-006860-a3b8hyyr	3048	15	should	should	MD
cord-006860-a3b8hyyr	3048	16	be	be	VB
cord-006860-a3b8hyyr	3048	17	given	give	VBN
cord-006860-a3b8hyyr	3048	18	after	after	IN
cord-006860-a3b8hyyr	3048	19	the	the	DT
cord-006860-a3b8hyyr	3048	20	end	end	NN
cord-006860-a3b8hyyr	3048	21	of	of	IN
cord-006860-a3b8hyyr	3048	22	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3048	23	treatment	treatment	NN
cord-006860-a3b8hyyr	3048	24	.	.	.
cord-006860-a3b8hyyr	3049	1	Fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3049	2	with	with	IN
cord-006860-a3b8hyyr	3049	3	the	the	DT
cord-006860-a3b8hyyr	3049	4	STA	STA	NNP
cord-006860-a3b8hyyr	3049	5	/	/	SYM
cord-006860-a3b8hyyr	3049	6	Stago	Stago	NNP
cord-006860-a3b8hyyr	3049	7	and	and	CC
cord-006860-a3b8hyyr	3049	8	the	the	DT
cord-006860-a3b8hyyr	3049	9	MLA	MLA	NNP
cord-006860-a3b8hyyr	3049	10	/	/	SYM
cord-006860-a3b8hyyr	3049	11	Dade	Dade	NNP
cord-006860-a3b8hyyr	3049	12	systems	system	NNS
cord-006860-a3b8hyyr	3049	13	correlated	correlate	VBD
cord-006860-a3b8hyyr	3049	14	well	well	RB
cord-006860-a3b8hyyr	3049	15	,	,	,
cord-006860-a3b8hyyr	3049	16	but	but	CC
cord-006860-a3b8hyyr	3049	17	neither	neither	DT
cord-006860-a3b8hyyr	3049	18	system	system	NN
cord-006860-a3b8hyyr	3049	19	correlated	correlate	VBD
cord-006860-a3b8hyyr	3049	20	well	well	RB
cord-006860-a3b8hyyr	3049	21	with	with	IN
cord-006860-a3b8hyyr	3049	22	the	the	DT
cord-006860-a3b8hyyr	3049	23	ACL	ACL	NNP
cord-006860-a3b8hyyr	3049	24	/	/	SYM
cord-006860-a3b8hyyr	3049	25	IL	IL	NNP
cord-006860-a3b8hyyr	3049	26	system	system	NN
cord-006860-a3b8hyyr	3049	27	.	.	.
cord-006860-a3b8hyyr	3050	1	AT	at	IN
cord-006860-a3b8hyyr	3050	2	III	III	NNP
cord-006860-a3b8hyyr	3050	3	,	,	,
cord-006860-a3b8hyyr	3050	4	protein	protein	NN
cord-006860-a3b8hyyr	3050	5	C	c	NN
cord-006860-a3b8hyyr	3050	6	,	,	,
cord-006860-a3b8hyyr	3050	7	protein	protein	NN
cord-006860-a3b8hyyr	3050	8	S	S	NNP
cord-006860-a3b8hyyr	3050	9	,	,	,
cord-006860-a3b8hyyr	3050	10	and	and	CC
cord-006860-a3b8hyyr	3050	11	anti	anti	JJ
cord-006860-a3b8hyyr	3050	12	-	-	JJ
cord-006860-a3b8hyyr	3050	13	Xa	xa	JJ
cord-006860-a3b8hyyr	3050	14	heparin	heparin	NN
cord-006860-a3b8hyyr	3050	15	assays	assay	NNS
cord-006860-a3b8hyyr	3050	16	using	use	VBG
cord-006860-a3b8hyyr	3050	17	Stago	Stago	NNP
cord-006860-a3b8hyyr	3050	18	reagents	reagent	NNS
cord-006860-a3b8hyyr	3050	19	performed	perform	VBN
cord-006860-a3b8hyyr	3050	20	as	as	IN
cord-006860-a3b8hyyr	3050	21	expected	expect	VBN
cord-006860-a3b8hyyr	3050	22	for	for	IN
cord-006860-a3b8hyyr	3050	23	normals	normal	NNS
cord-006860-a3b8hyyr	3050	24	and	and	CC
cord-006860-a3b8hyyr	3050	25	low	low	JJ
cord-006860-a3b8hyyr	3050	26	abnormals	abnormal	NNS
cord-006860-a3b8hyyr	3050	27	on	on	IN
cord-006860-a3b8hyyr	3050	28	the	the	DT
cord-006860-a3b8hyyr	3050	29	STA	STA	NNP
cord-006860-a3b8hyyr	3050	30	.	.	.
cord-006860-a3b8hyyr	3051	1	Factor	factor	NN
cord-006860-a3b8hyyr	3051	2	levels	level	NNS
cord-006860-a3b8hyyr	3051	3	on	on	IN
cord-006860-a3b8hyyr	3051	4	the	the	DT
cord-006860-a3b8hyyr	3051	5	STA	STA	NNP
cord-006860-a3b8hyyr	3051	6	/	/	SYM
cord-006860-a3b8hyyr	3051	7	Stago	Stago	NNP
cord-006860-a3b8hyyr	3051	8	system	system	NN
cord-006860-a3b8hyyr	3051	9	were	be	VBD
cord-006860-a3b8hyyr	3051	10	less	less	RBR
cord-006860-a3b8hyyr	3051	11	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	3051	12	than	than	IN
cord-006860-a3b8hyyr	3051	13	factor	factor	NN
cord-006860-a3b8hyyr	3051	14	levels	level	NNS
cord-006860-a3b8hyyr	3051	15	obtained	obtain	VBN
cord-006860-a3b8hyyr	3051	16	with	with	IN
cord-006860-a3b8hyyr	3051	17	the	the	DT
cord-006860-a3b8hyyr	3051	18	Dade	Dade	NNP
cord-006860-a3b8hyyr	3051	19	reagents	reagent	NNS
cord-006860-a3b8hyyr	3051	20	on	on	IN
cord-006860-a3b8hyyr	3051	21	the	the	DT
cord-006860-a3b8hyyr	3051	22	MLA	MLA	NNP
cord-006860-a3b8hyyr	3051	23	or	or	CC
cord-006860-a3b8hyyr	3051	24	Fibrometer	Fibrometer	NNP
cord-006860-a3b8hyyr	3051	25	.	.	.
cord-006860-a3b8hyyr	3052	1	Using	use	VBG
cord-006860-a3b8hyyr	3052	2	the	the	DT
cord-006860-a3b8hyyr	3052	3	STA	STA	NNP
cord-006860-a3b8hyyr	3052	4	/	/	SYM
cord-006860-a3b8hyyr	3052	5	Stago	Stago	NNP
cord-006860-a3b8hyyr	3052	6	system	system	NN
cord-006860-a3b8hyyr	3052	7	,	,	,
cord-006860-a3b8hyyr	3052	8	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3052	9	time	time	NN
cord-006860-a3b8hyyr	3052	10	results	result	NNS
cord-006860-a3b8hyyr	3052	11	correlated	correlate	VBN
cord-006860-a3b8hyyr	3052	12	well	well	RB
cord-006860-a3b8hyyr	3052	13	with	with	IN
cord-006860-a3b8hyyr	3052	14	the	the	DT
cord-006860-a3b8hyyr	3052	15	APTT	APTT	NNP
cord-006860-a3b8hyyr	3052	16	and	and	CC
cord-006860-a3b8hyyr	3052	17	heparin	heparin	NN
cord-006860-a3b8hyyr	3052	18	levels	level	NNS
cord-006860-a3b8hyyr	3052	19	.	.	.
cord-006860-a3b8hyyr	3053	1	The	the	DT
cord-006860-a3b8hyyr	3053	2	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3053	3	time	time	NN
cord-006860-a3b8hyyr	3053	4	was	be	VBD
cord-006860-a3b8hyyr	3053	5	not	not	RB
cord-006860-a3b8hyyr	3053	6	associated	associate	VBN
cord-006860-a3b8hyyr	3053	7	with	with	IN
cord-006860-a3b8hyyr	3053	8	additional	additional	JJ
cord-006860-a3b8hyyr	3053	9	manipulation	manipulation	NN
cord-006860-a3b8hyyr	3053	10	for	for	IN
cord-006860-a3b8hyyr	3053	11	assay	assay	NN
cord-006860-a3b8hyyr	3053	12	preparation	preparation	NN
cord-006860-a3b8hyyr	3053	13	,	,	,
cord-006860-a3b8hyyr	3053	14	nor	nor	CC
cord-006860-a3b8hyyr	3053	15	any	any	DT
cord-006860-a3b8hyyr	3053	16	cross	cross	NN
cord-006860-a3b8hyyr	3053	17	-	-	JJ
cord-006860-a3b8hyyr	3053	18	contamination	contamination	NN
cord-006860-a3b8hyyr	3053	19	of	of	IN
cord-006860-a3b8hyyr	3053	20	reagent	reagent	NN
cord-006860-a3b8hyyr	3053	21	or	or	CC
cord-006860-a3b8hyyr	3053	22	sample	sample	NN
cord-006860-a3b8hyyr	3053	23	,	,	,
cord-006860-a3b8hyyr	3053	24	since	since	IN
cord-006860-a3b8hyyr	3053	25	on	on	IN
cord-006860-a3b8hyyr	3053	26	the	the	DT
cord-006860-a3b8hyyr	3053	27	STA	STA	NNP
cord-006860-a3b8hyyr	3053	28	reagents	reagent	NNS
cord-006860-a3b8hyyr	3053	29	do	do	VBP
cord-006860-a3b8hyyr	3053	30	not	not	RB
cord-006860-a3b8hyyr	3053	31	come	come	VB
cord-006860-a3b8hyyr	3053	32	into	into	IN
cord-006860-a3b8hyyr	3053	33	contact	contact	NN
cord-006860-a3b8hyyr	3053	34	with	with	IN
cord-006860-a3b8hyyr	3053	35	tubing	tubing	NN
cord-006860-a3b8hyyr	3053	36	.	.	.
cord-006860-a3b8hyyr	3054	1	The	the	DT
cord-006860-a3b8hyyr	3054	2	STA	STA	NNP
cord-006860-a3b8hyyr	3054	3	was	be	VBD
cord-006860-a3b8hyyr	3054	4	not	not	RB
cord-006860-a3b8hyyr	3054	5	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	3054	6	to	to	IN
cord-006860-a3b8hyyr	3054	7	hemolytic	hemolytic	JJ
cord-006860-a3b8hyyr	3054	8	,	,	,
cord-006860-a3b8hyyr	3054	9	icteric	icteric	JJ
cord-006860-a3b8hyyr	3054	10	or	or	CC
cord-006860-a3b8hyyr	3054	11	lipernic	lipernic	JJ
cord-006860-a3b8hyyr	3054	12	samples	sample	NNS
cord-006860-a3b8hyyr	3054	13	for	for	IN
cord-006860-a3b8hyyr	3054	14	clotting	clotting	NN
cord-006860-a3b8hyyr	3054	15	assays	assay	NNS
cord-006860-a3b8hyyr	3054	16	artd	artd	NNP
cord-006860-a3b8hyyr	3054	17	showed	show	VBD
cord-006860-a3b8hyyr	3054	18	the	the	DT
cord-006860-a3b8hyyr	3054	19	same	same	JJ
cord-006860-a3b8hyyr	3054	20	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	3054	21	as	as	IN
cord-006860-a3b8hyyr	3054	22	the	the	DT
cord-006860-a3b8hyyr	3054	23	MLA	MLA	NNP
cord-006860-a3b8hyyr	3054	24	for	for	IN
cord-006860-a3b8hyyr	3054	25	chromogenic	chromogenic	NNP
cord-006860-a3b8hyyr	3054	26	assays	assay	NNS
cord-006860-a3b8hyyr	3054	27	.	.	.
cord-006860-a3b8hyyr	3055	1	The	the	DT
cord-006860-a3b8hyyr	3055	2	overall	overall	JJ
cord-006860-a3b8hyyr	3055	3	data	datum	NNS
cord-006860-a3b8hyyr	3055	4	comparisons	comparison	NNS
cord-006860-a3b8hyyr	3055	5	,	,	,
cord-006860-a3b8hyyr	3055	6	high	high	JJ
cord-006860-a3b8hyyr	3055	7	throughput	throughput	NN
cord-006860-a3b8hyyr	3055	8	,	,	,
cord-006860-a3b8hyyr	3055	9	minimal	minimal	JJ
cord-006860-a3b8hyyr	3055	10	operator	operator	NN
cord-006860-a3b8hyyr	3055	11	intervention	intervention	NN
cord-006860-a3b8hyyr	3055	12	for	for	IN
cord-006860-a3b8hyyr	3055	13	reagent	reagent	NN
cord-006860-a3b8hyyr	3055	14	/	/	SYM
cord-006860-a3b8hyyr	3055	15	assay	assay	NN
cord-006860-a3b8hyyr	3055	16	change	change	NN
cord-006860-a3b8hyyr	3055	17	and	and	CC
cord-006860-a3b8hyyr	3055	18	ease	ease	NN
cord-006860-a3b8hyyr	3055	19	of	of	IN
cord-006860-a3b8hyyr	3055	20	operation	operation	NN
cord-006860-a3b8hyyr	3055	21	warrant	warrant	VBP
cord-006860-a3b8hyyr	3055	22	further	further	JJ
cord-006860-a3b8hyyr	3055	23	evaluation	evaluation	NN
cord-006860-a3b8hyyr	3055	24	of	of	IN
cord-006860-a3b8hyyr	3055	25	the	the	DT
cord-006860-a3b8hyyr	3055	26	STA	STA	NNP
cord-006860-a3b8hyyr	3055	27	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	3055	28	analyzer	analyzer	NN
cord-006860-a3b8hyyr	3055	29	.	.	.
cord-006860-a3b8hyyr	3056	1	A.	A.	NNP
cord-006860-a3b8hyyr	3056	2	Wehmeier	Wehmeier	NNP
cord-006860-a3b8hyyr	3056	3	,	,	,
cord-006860-a3b8hyyr	3056	4	D.	D.	NNP
cord-006860-a3b8hyyr	3056	5	S6hngen	S6hngen	NNP
cord-006860-a3b8hyyr	3056	6	,	,	,
cord-006860-a3b8hyyr	3056	7	C.	C.	NNP
cord-006860-a3b8hyyr	3056	8	Rieth	Rieth	NNP
cord-006860-a3b8hyyr	3056	9	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	3056	10	for	for	IN
cord-006860-a3b8hyyr	3056	11	H#,matologie	h#,matologie	NN
cord-006860-a3b8hyyr	3056	12	,	,	,
cord-006860-a3b8hyyr	3056	13	Onkologie	Onkologie	NNP
cord-006860-a3b8hyyr	3056	14	und	und	IN
cord-006860-a3b8hyyr	3056	15	klinische	klinische	NNP
cord-006860-a3b8hyyr	3056	16	Immunologie	Immunologie	NNP
cord-006860-a3b8hyyr	3056	17	der	der	NNP
cord-006860-a3b8hyyr	3056	18	Heinrich	Heinrich	NNP
cord-006860-a3b8hyyr	3056	19	-	-	HYPH
cord-006860-a3b8hyyr	3056	20	Heine	Heine	NNP
cord-006860-a3b8hyyr	3056	21	-	-	HYPH
cord-006860-a3b8hyyr	3056	22	Universit	Universit	NNP
cord-006860-a3b8hyyr	3057	1	~it	~it	NNP
cord-006860-a3b8hyyr	3057	2	D0sseldorf	D0sseldorf	NNP
cord-006860-a3b8hyyr	3058	1	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3058	2	selectively	selectively	RB
cord-006860-a3b8hyyr	3058	3	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	3058	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3058	5	by	by	IN
cord-006860-a3b8hyyr	3058	6	direct	direct	JJ
cord-006860-a3b8hyyr	3058	7	interaction	interaction	NN
cord-006860-a3b8hyyr	3058	8	.	.	.
cord-006860-a3b8hyyr	3059	1	Because	because	IN
cord-006860-a3b8hyyr	3059	2	the	the	DT
cord-006860-a3b8hyyr	3059	3	effect	effect	NN
cord-006860-a3b8hyyr	3059	4	of	of	IN
cord-006860-a3b8hyyr	3059	5	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3059	6	is	be	VBZ
cord-006860-a3b8hyyr	3059	7	independent	independent	JJ
cord-006860-a3b8hyyr	3059	8	of	of	IN
cord-006860-a3b8hyyr	3059	9	antithrombin	antithrombin	NNP
cord-006860-a3b8hyyr	3059	10	III	III	NNP
cord-006860-a3b8hyyr	3059	11	and	and	CC
cord-006860-a3b8hyyr	3059	12	other	other	JJ
cord-006860-a3b8hyyr	3059	13	factors	factor	NNS
cord-006860-a3b8hyyr	3059	14	,	,	,
cord-006860-a3b8hyyr	3059	15	it	-PRON-	PRP
cord-006860-a3b8hyyr	3059	16	seems	seem	VBZ
cord-006860-a3b8hyyr	3059	17	an	an	DT
cord-006860-a3b8hyyr	3059	18	attractive	attractive	JJ
cord-006860-a3b8hyyr	3059	19	alternative	alternative	NN
cord-006860-a3b8hyyr	3059	20	to	to	IN
cord-006860-a3b8hyyr	3059	21	current	current	JJ
cord-006860-a3b8hyyr	3059	22	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	3059	23	.	.	.
cord-006860-a3b8hyyr	3060	1	However	however	RB
cord-006860-a3b8hyyr	3060	2	,	,	,
cord-006860-a3b8hyyr	3060	3	it	-PRON-	PRP
cord-006860-a3b8hyyr	3060	4	is	be	VBZ
cord-006860-a3b8hyyr	3060	5	uncertain	uncertain	JJ
cord-006860-a3b8hyyr	3060	6	whether	whether	IN
cord-006860-a3b8hyyr	3060	7	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3060	8	influences	influence	NNS
cord-006860-a3b8hyyr	3060	9	plateletassociated	plateletassociate	VBD
cord-006860-a3b8hyyr	3060	10	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	3060	11	disorders	disorder	NNS
cord-006860-a3b8hyyr	3060	12	and	and	CC
cord-006860-a3b8hyyr	3060	13	how	how	WRB
cord-006860-a3b8hyyr	3060	14	it	-PRON-	PRP
cord-006860-a3b8hyyr	3060	15	compares	compare	VBZ
cord-006860-a3b8hyyr	3060	16	with	with	IN
cord-006860-a3b8hyyr	3060	17	conventional	conventional	JJ
cord-006860-a3b8hyyr	3060	18	and	and	CC
cord-006860-a3b8hyyr	3060	19	LMW	lmw	VBP
cord-006860-a3b8hyyr	3060	20	heparin	heparin	JJ
cord-006860-a3b8hyyr	3060	21	.	.	.
cord-006860-a3b8hyyr	3061	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3061	2	investigated	investigate	VBD
cord-006860-a3b8hyyr	3061	3	the	the	DT
cord-006860-a3b8hyyr	3061	4	effect	effect	NN
cord-006860-a3b8hyyr	3061	5	of	of	IN
cord-006860-a3b8hyyr	3061	6	2	2	CD
cord-006860-a3b8hyyr	3061	7	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	3061	8	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3061	9	preparations	preparation	NNS
cord-006860-a3b8hyyr	3061	10	(	(	-LRB-
cord-006860-a3b8hyyr	3061	11	Rhein	Rhein	NNP
cord-006860-a3b8hyyr	3061	12	Biotech	Biotech	NNP
cord-006860-a3b8hyyr	3061	13	,	,	,
cord-006860-a3b8hyyr	3061	14	Dt3sseldorf	dt3sseldorf	NN
cord-006860-a3b8hyyr	3061	15	)	)	-RRB-
cord-006860-a3b8hyyr	3061	16	on	on	IN
cord-006860-a3b8hyyr	3061	17	platelet	platelet	NN
cord-006860-a3b8hyyr	3061	18	function	function	NN
cord-006860-a3b8hyyr	3061	19	tests	test	NNS
cord-006860-a3b8hyyr	3061	20	:	:	:
cord-006860-a3b8hyyr	3061	21	in	in	IN
cord-006860-a3b8hyyr	3061	22	vitro	vitro	FW
cord-006860-a3b8hyyr	3061	23	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3061	24	time	time	NN
cord-006860-a3b8hyyr	3061	25	,	,	,
cord-006860-a3b8hyyr	3061	26	adhesion	adhesion	NN
cord-006860-a3b8hyyr	3061	27	to	to	IN
cord-006860-a3b8hyyr	3061	28	glass	glass	NN
cord-006860-a3b8hyyr	3061	29	beads	bead	NNS
cord-006860-a3b8hyyr	3061	30	,	,	,
cord-006860-a3b8hyyr	3061	31	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3061	32	in	in	IN
cord-006860-a3b8hyyr	3061	33	platelet	platelet	NN
cord-006860-a3b8hyyr	3061	34	-	-	HYPH
cord-006860-a3b8hyyr	3061	35	rich	rich	JJ
cord-006860-a3b8hyyr	3061	36	plasma	plasma	NN
cord-006860-a3b8hyyr	3061	37	and	and	CC
cord-006860-a3b8hyyr	3061	38	whole	whole	JJ
cord-006860-a3b8hyyr	3061	39	blood	blood	NN
cord-006860-a3b8hyyr	3061	40	.	.	.
cord-006860-a3b8hyyr	3062	1	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3062	2	was	be	VBD
cord-006860-a3b8hyyr	3062	3	used	use	VBN
cord-006860-a3b8hyyr	3062	4	in	in	IN
cord-006860-a3b8hyyr	3062	5	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3062	6	of	of	IN
cord-006860-a3b8hyyr	3062	7	0.1	0.1	CD
cord-006860-a3b8hyyr	3062	8	-	-	SYM
cord-006860-a3b8hyyr	3062	9	100	100	CD
cord-006860-a3b8hyyr	3062	10	I.tg/mi	i.tg/mi	NN
cord-006860-a3b8hyyr	3062	11	,	,	,
cord-006860-a3b8hyyr	3062	12	and	and	CC
cord-006860-a3b8hyyr	3062	13	was	be	VBD
cord-006860-a3b8hyyr	3062	14	compared	compare	VBN
cord-006860-a3b8hyyr	3062	15	to	to	IN
cord-006860-a3b8hyyr	3062	16	trisodium	trisodium	NNP
cord-006860-a3b8hyyr	3062	17	citrate	citrate	NNP
cord-006860-a3b8hyyr	3062	18	(	(	-LRB-
cord-006860-a3b8hyyr	3062	19	0.38	0.38	CD
cord-006860-a3b8hyyr	3062	20	%	%	NN
cord-006860-a3b8hyyr	3062	21	)	)	-RRB-
cord-006860-a3b8hyyr	3062	22	,	,	,
cord-006860-a3b8hyyr	3062	23	conventional	conventional	JJ
cord-006860-a3b8hyyr	3062	24	heparin	heparin	NN
cord-006860-a3b8hyyr	3062	25	(	(	-LRB-
cord-006860-a3b8hyyr	3062	26	50	50	CD
cord-006860-a3b8hyyr	3062	27	IU	IU	NNP
cord-006860-a3b8hyyr	3062	28	/	/	SYM
cord-006860-a3b8hyyr	3062	29	ml	ml	NN
cord-006860-a3b8hyyr	3062	30	)	)	-RRB-
cord-006860-a3b8hyyr	3062	31	or	or	CC
cord-006860-a3b8hyyr	3062	32	LMW	lmw	VB
cord-006860-a3b8hyyr	3062	33	heparin	heparin	NN
cord-006860-a3b8hyyr	3062	34	(	(	-LRB-
cord-006860-a3b8hyyr	3062	35	Fraxiparin	Fraxiparin	NNP
cord-006860-a3b8hyyr	3062	36	,	,	,
cord-006860-a3b8hyyr	3062	37	500	500	CD
cord-006860-a3b8hyyr	3062	38	IU	IU	NNP
cord-006860-a3b8hyyr	3062	39	/	/	SYM
cord-006860-a3b8hyyr	3062	40	ml	ml	NN
cord-006860-a3b8hyyr	3062	41	)	)	-RRB-
cord-006860-a3b8hyyr	3062	42	.	.	.
cord-006860-a3b8hyyr	3063	1	Both	both	DT
cord-006860-a3b8hyyr	3063	2	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	3063	3	hirudins	hirudin	NNS
cord-006860-a3b8hyyr	3063	4	showed	show	VBD
cord-006860-a3b8hyyr	3063	5	normal	normal	JJ
cord-006860-a3b8hyyr	3063	6	activity	activity	NN
cord-006860-a3b8hyyr	3063	7	in	in	IN
cord-006860-a3b8hyyr	3063	8	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3063	9	neutralization	neutralization	NN
cord-006860-a3b8hyyr	3063	10	tests	test	NNS
cord-006860-a3b8hyyr	3063	11	,	,	,
cord-006860-a3b8hyyr	3063	12	and	and	CC
cord-006860-a3b8hyyr	3063	13	prolongation	prolongation	NN
cord-006860-a3b8hyyr	3063	14	of	of	IN
cord-006860-a3b8hyyr	3063	15	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3063	16	time	time	NN
cord-006860-a3b8hyyr	3063	17	and	and	CC
cord-006860-a3b8hyyr	3063	18	aPTT	aptt	NN
cord-006860-a3b8hyyr	3063	19	.	.	.
cord-006860-a3b8hyyr	3064	1	However	however	RB
cord-006860-a3b8hyyr	3064	2	,	,	,
cord-006860-a3b8hyyr	3064	3	in	in	IN
cord-006860-a3b8hyyr	3064	4	vitro	vitro	FW
cord-006860-a3b8hyyr	3064	5	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3064	6	time	time	NN
cord-006860-a3b8hyyr	3064	7	was	be	VBD
cord-006860-a3b8hyyr	3064	8	not	not	RB
cord-006860-a3b8hyyr	3064	9	prolonged	prolong	VBN
cord-006860-a3b8hyyr	3064	10	by	by	IN
cord-006860-a3b8hyyr	3064	11	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3064	12	,	,	,
cord-006860-a3b8hyyr	3064	13	but	but	CC
cord-006860-a3b8hyyr	3064	14	was	be	VBD
cord-006860-a3b8hyyr	3064	15	more	more	JJR
cord-006860-a3b8hyyr	3064	16	than	than	IN
cord-006860-a3b8hyyr	3064	17	doubled	double	VBN
cord-006860-a3b8hyyr	3064	18	by	by	IN
cord-006860-a3b8hyyr	3064	19	addition	addition	NN
cord-006860-a3b8hyyr	3064	20	of	of	IN
cord-006860-a3b8hyyr	3064	21	conventional	conventional	JJ
cord-006860-a3b8hyyr	3064	22	and	and	CC
cord-006860-a3b8hyyr	3064	23	LMW	lmw	NN
cord-006860-a3b8hyyr	3064	24	heparins	heparin	NNS
cord-006860-a3b8hyyr	3064	25	.	.	.
cord-006860-a3b8hyyr	3065	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	3065	2	retention	retention	NN
cord-006860-a3b8hyyr	3065	3	to	to	IN
cord-006860-a3b8hyyr	3065	4	glass	glass	NN
cord-006860-a3b8hyyr	3065	5	bead	bead	NN
cord-006860-a3b8hyyr	3065	6	columns	column	NNS
cord-006860-a3b8hyyr	3065	7	was	be	VBD
cord-006860-a3b8hyyr	3065	8	reduced	reduce	VBN
cord-006860-a3b8hyyr	3065	9	by	by	IN
cord-006860-a3b8hyyr	3065	10	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3065	11	in	in	IN
cord-006860-a3b8hyyr	3065	12	a	a	DT
cord-006860-a3b8hyyr	3065	13	dose	dose	NN
cord-006860-a3b8hyyr	3065	14	-	-	HYPH
cord-006860-a3b8hyyr	3065	15	dependent	dependent	JJ
cord-006860-a3b8hyyr	3065	16	manner	manner	NN
cord-006860-a3b8hyyr	3065	17	to	to	IN
cord-006860-a3b8hyyr	3065	18	about	about	RB
cord-006860-a3b8hyyr	3065	19	40	40	CD
cord-006860-a3b8hyyr	3065	20	%	%	NN
cord-006860-a3b8hyyr	3065	21	but	but	CC
cord-006860-a3b8hyyr	3065	22	was	be	VBD
cord-006860-a3b8hyyr	3065	23	more	more	RBR
cord-006860-a3b8hyyr	3065	24	effectively	effectively	RB
cord-006860-a3b8hyyr	3065	25	reduced	reduce	VBN
cord-006860-a3b8hyyr	3065	26	by	by	IN
cord-006860-a3b8hyyr	3065	27	both	both	DT
cord-006860-a3b8hyyr	3065	28	heparin	heparin	NN
cord-006860-a3b8hyyr	3065	29	preparations	preparation	NNS
cord-006860-a3b8hyyr	3065	30	and	and	CC
cord-006860-a3b8hyyr	3065	31	citrate	citrate	NN
cord-006860-a3b8hyyr	3065	32	.	.	.
cord-006860-a3b8hyyr	3066	1	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3066	2	had	have	VBD
cord-006860-a3b8hyyr	3066	3	an	an	DT
cord-006860-a3b8hyyr	3066	4	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	3066	5	effect	effect	NN
cord-006860-a3b8hyyr	3066	6	on	on	IN
cord-006860-a3b8hyyr	3066	7	p!atelet	p!atelet	NNP
cord-006860-a3b8hyyr	3066	8	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3066	9	in	in	IN
cord-006860-a3b8hyyr	3066	10	PRP	PRP	NNP
cord-006860-a3b8hyyr	3066	11	induced	induce	VBN
cord-006860-a3b8hyyr	3066	12	by	by	IN
cord-006860-a3b8hyyr	3066	13	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3066	14	,	,	,
cord-006860-a3b8hyyr	3066	15	collagen	collagen	NN
cord-006860-a3b8hyyr	3066	16	,	,	,
cord-006860-a3b8hyyr	3066	17	and	and	CC
cord-006860-a3b8hyyr	3066	18	predominantly	predominantly	RB
cord-006860-a3b8hyyr	3066	19	epinephrine	epinephrine	NN
cord-006860-a3b8hyyr	3066	20	but	but	CC
cord-006860-a3b8hyyr	3066	21	not	not	RB
cord-006860-a3b8hyyr	3066	22	ADP	ADP	NNP
cord-006860-a3b8hyyr	3066	23	and	and	CC
cord-006860-a3b8hyyr	3066	24	ristocetin	ristocetin	NNP
cord-006860-a3b8hyyr	3066	25	.	.	.
cord-006860-a3b8hyyr	3067	1	In	in	IN
cord-006860-a3b8hyyr	3067	2	whole	whole	JJ
cord-006860-a3b8hyyr	3067	3	blood	blood	NN
cord-006860-a3b8hyyr	3067	4	,	,	,
cord-006860-a3b8hyyr	3067	5	a	a	DT
cord-006860-a3b8hyyr	3067	6	small	small	JJ
cord-006860-a3b8hyyr	3067	7	effect	effect	NN
cord-006860-a3b8hyyr	3067	8	could	could	MD
cord-006860-a3b8hyyr	3067	9	only	only	RB
cord-006860-a3b8hyyr	3067	10	be	be	VB
cord-006860-a3b8hyyr	3067	11	observed	observe	VBN
cord-006860-a3b8hyyr	3067	12	with	with	IN
cord-006860-a3b8hyyr	3067	13	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3067	14	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3067	15	of	of	IN
cord-006860-a3b8hyyr	3067	16	>	>	$
cord-006860-a3b8hyyr	3067	17	25	25	CD
cord-006860-a3b8hyyr	3067	18	~g	~g	NNP
cord-006860-a3b8hyyr	3067	19	/	/	SYM
cord-006860-a3b8hyyr	3067	20	ml	ml	NN
cord-006860-a3b8hyyr	3067	21	as	as	IN
cord-006860-a3b8hyyr	3067	22	compared	compare	VBN
cord-006860-a3b8hyyr	3067	23	to	to	IN
cord-006860-a3b8hyyr	3067	24	citrateanticoagulated	citrateanticoagulate	VBN
cord-006860-a3b8hyyr	3067	25	blood	blood	NN
cord-006860-a3b8hyyr	3067	26	.	.	.
cord-006860-a3b8hyyr	3068	1	In	in	IN
cord-006860-a3b8hyyr	3068	2	summary	summary	NN
cord-006860-a3b8hyyr	3068	3	,	,	,
cord-006860-a3b8hyyr	3068	4	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3068	5	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3068	6	by	by	IN
cord-006860-a3b8hyyr	3068	7	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	3068	8	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3068	9	has	have	VBZ
cord-006860-a3b8hyyr	3068	10	little	little	JJ
cord-006860-a3b8hyyr	3068	11	effect	effect	NN
cord-006860-a3b8hyyr	3068	12	on	on	IN
cord-006860-a3b8hyyr	3068	13	in	in	IN
cord-006860-a3b8hyyr	3068	14	vitro	vitro	FW
cord-006860-a3b8hyyr	3068	15	platelet	platelet	NN
cord-006860-a3b8hyyr	3068	16	function	function	NN
cord-006860-a3b8hyyr	3068	17	tests	test	NNS
cord-006860-a3b8hyyr	3068	18	in	in	IN
cord-006860-a3b8hyyr	3068	19	comparison	comparison	NN
cord-006860-a3b8hyyr	3068	20	to	to	IN
cord-006860-a3b8hyyr	3068	21	heparins	heparin	NNS
cord-006860-a3b8hyyr	3068	22	and	and	CC
cord-006860-a3b8hyyr	3068	23	calcium	calcium	NN
cord-006860-a3b8hyyr	3068	24	depletion	depletion	NN
cord-006860-a3b8hyyr	3068	25	.	.	.
cord-006860-a3b8hyyr	3069	1	The	the	DT
cord-006860-a3b8hyyr	3069	2	role	role	NN
cord-006860-a3b8hyyr	3069	3	of	of	IN
cord-006860-a3b8hyyr	3069	4	endothelin	endothelin	NNP
cord-006860-a3b8hyyr	3069	5	(	(	-LRB-
cord-006860-a3b8hyyr	3069	6	ET	ET	NNP
cord-006860-a3b8hyyr	3069	7	)	)	-RRB-
cord-006860-a3b8hyyr	3069	8	,	,	,
cord-006860-a3b8hyyr	3069	9	prostaglandins	prostaglandin	NNS
cord-006860-a3b8hyyr	3069	10	and	and	CC
cord-006860-a3b8hyyr	3069	11	the	the	DT
cord-006860-a3b8hyyr	3069	12	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3069	13	system	system	NN
cord-006860-a3b8hyyr	3069	14	in	in	IN
cord-006860-a3b8hyyr	3069	15	the	the	DT
cord-006860-a3b8hyyr	3069	16	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	3069	17	of	of	IN
cord-006860-a3b8hyyr	3069	18	acute	acute	JJ
cord-006860-a3b8hyyr	3069	19	renal	renal	JJ
cord-006860-a3b8hyyr	3069	20	failure	failure	NN
cord-006860-a3b8hyyr	3069	21	is	be	VBZ
cord-006860-a3b8hyyr	3069	22	still	still	RB
cord-006860-a3b8hyyr	3069	23	to	to	TO
cord-006860-a3b8hyyr	3069	24	be	be	VB
cord-006860-a3b8hyyr	3069	25	defined	define	VBN
cord-006860-a3b8hyyr	3069	26	.	.	.
cord-006860-a3b8hyyr	3070	1	In	in	IN
cord-006860-a3b8hyyr	3070	2	anaesthesized	anaesthesized	JJ
cord-006860-a3b8hyyr	3070	3	pigs	pig	NNS
cord-006860-a3b8hyyr	3070	4	the	the	DT
cord-006860-a3b8hyyr	3070	5	effects	effect	NNS
cord-006860-a3b8hyyr	3070	6	of	of	IN
cord-006860-a3b8hyyr	3070	7	i.v	i.v	NNP
cord-006860-a3b8hyyr	3070	8	.	.	.
cord-006860-a3b8hyyr	3070	9	infusion	infusion	NN
cord-006860-a3b8hyyr	3070	10	of	of	IN
cord-006860-a3b8hyyr	3070	11	ET	ET	NNP
cord-006860-a3b8hyyr	3070	12	(	(	-LRB-
cord-006860-a3b8hyyr	3070	13	3	3	CD
cord-006860-a3b8hyyr	3070	14	/~g	/~g	NN
cord-006860-a3b8hyyr	3070	15	/	/	SYM
cord-006860-a3b8hyyr	3070	16	kg	kg	NN
cord-006860-a3b8hyyr	3070	17	)	)	-RRB-
cord-006860-a3b8hyyr	3071	1	alone	alone	JJ
cord-006860-a3b8hyyr	3071	2	(	(	-LRB-
cord-006860-a3b8hyyr	3071	3	group	group	NN
cord-006860-a3b8hyyr	3071	4	1	1	CD
cord-006860-a3b8hyyr	3071	5	,	,	,
cord-006860-a3b8hyyr	3071	6	n=6	n=6	JJ
cord-006860-a3b8hyyr	3071	7	)	)	-RRB-
cord-006860-a3b8hyyr	3071	8	and	and	CC
cord-006860-a3b8hyyr	3071	9	after	after	IN
cord-006860-a3b8hyyr	3071	10	pretreatment	pretreatment	NN
cord-006860-a3b8hyyr	3071	11	with	with	IN
cord-006860-a3b8hyyr	3071	12	the	the	DT
cord-006860-a3b8hyyr	3071	13	potent	potent	JJ
cord-006860-a3b8hyyr	3071	14	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3071	15	-	-	HYPH
cord-006860-a3b8hyyr	3071	16	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3071	17	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3071	18	(	(	-LRB-
cord-006860-a3b8hyyr	3071	19	0,5	0,5	CD
cord-006860-a3b8hyyr	3071	20	mg	mg	NNP
cord-006860-a3b8hyyr	3071	21	/	/	SYM
cord-006860-a3b8hyyr	3071	22	kg)(group	kg)(group	NNP
cord-006860-a3b8hyyr	3071	23	2	2	CD
cord-006860-a3b8hyyr	3071	24	,	,	,
cord-006860-a3b8hyyr	3071	25	n=6	n=6	JJ
cord-006860-a3b8hyyr	3071	26	)	)	-RRB-
cord-006860-a3b8hyyr	3071	27	on	on	IN
cord-006860-a3b8hyyr	3071	28	haemodynamics	haemodynamic	NNS
cord-006860-a3b8hyyr	3071	29	,	,	,
cord-006860-a3b8hyyr	3071	30	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3071	31	parameters	parameter	NNS
cord-006860-a3b8hyyr	3071	32	(	(	-LRB-
cord-006860-a3b8hyyr	3071	33	factor	factor	NN
cord-006860-a3b8hyyr	3071	34	VIII	VIII	NNP
cord-006860-a3b8hyyr	3071	35	,	,	,
cord-006860-a3b8hyyr	3071	36	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3071	37	III	III	NNP
cord-006860-a3b8hyyr	3071	38	,	,	,
cord-006860-a3b8hyyr	3071	39	precallicrein	precallicrein	NNP
cord-006860-a3b8hyyr	3071	40	,	,	,
cord-006860-a3b8hyyr	3071	41	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3071	42	monomers	monomer	NNS
cord-006860-a3b8hyyr	3071	43	,	,	,
cord-006860-a3b8hyyr	3071	44	aPTT	aptt	CD
cord-006860-a3b8hyyr	3071	45	)	)	-RRB-
cord-006860-a3b8hyyr	3071	46	and	and	CC
cord-006860-a3b8hyyr	3071	47	prostaglandins	prostaglandin	NNS
cord-006860-a3b8hyyr	3071	48	were	be	VBD
cord-006860-a3b8hyyr	3071	49	investigated	investigate	VBN
cord-006860-a3b8hyyr	3071	50	.	.	.
cord-006860-a3b8hyyr	3072	1	Plasma	plasma	NN
cord-006860-a3b8hyyr	3072	2	renin	renin	NN
cord-006860-a3b8hyyr	3072	3	activity	activity	NN
cord-006860-a3b8hyyr	3072	4	(	(	-LRB-
cord-006860-a3b8hyyr	3072	5	PRA)-	PRA)-	NNP
cord-006860-a3b8hyyr	3072	6	,	,	,
cord-006860-a3b8hyyr	3072	7	creatinine	creatinine	NN
cord-006860-a3b8hyyr	3072	8	clearance-	clearance-	NNS
cord-006860-a3b8hyyr	3072	9	,	,	,
cord-006860-a3b8hyyr	3072	10	urine	urine	NN
cord-006860-a3b8hyyr	3072	11	volume	volume	NN
cord-006860-a3b8hyyr	3072	12	-	-	HYPH
cord-006860-a3b8hyyr	3072	13	measurement	measurement	NN
cord-006860-a3b8hyyr	3072	14	and	and	CC
cord-006860-a3b8hyyr	3072	15	blood	blood	NN
cord-006860-a3b8hyyr	3072	16	gas	gas	NN
cord-006860-a3b8hyyr	3072	17	analysis	analysis	NN
cord-006860-a3b8hyyr	3072	18	were	be	VBD
cord-006860-a3b8hyyr	3072	19	performed	perform	VBN
cord-006860-a3b8hyyr	3072	20	hourly	hourly	RB
cord-006860-a3b8hyyr	3072	21	.	.	.
cord-006860-a3b8hyyr	3073	1	ET	et	NN
cord-006860-a3b8hyyr	3073	2	-	-	HYPH
cord-006860-a3b8hyyr	3073	3	infusion	infusion	NN
cord-006860-a3b8hyyr	3073	4	caused	cause	VBD
cord-006860-a3b8hyyr	3073	5	an	an	DT
cord-006860-a3b8hyyr	3073	6	initial	initial	JJ
cord-006860-a3b8hyyr	3073	7	BP	BP	NNP
cord-006860-a3b8hyyr	3073	8	-	-	HYPH
cord-006860-a3b8hyyr	3073	9	reduction	reduction	NN
cord-006860-a3b8hyyr	3073	10	and	and	CC
cord-006860-a3b8hyyr	3073	11	marked	mark	VBD
cord-006860-a3b8hyyr	3073	12	HR	hr	NN
cord-006860-a3b8hyyr	3073	13	-	-	HYPH
cord-006860-a3b8hyyr	3073	14	reduction	reduction	NN
cord-006860-a3b8hyyr	3073	15	followed	follow	VBN
cord-006860-a3b8hyyr	3073	16	by	by	IN
cord-006860-a3b8hyyr	3073	17	a	a	DT
cord-006860-a3b8hyyr	3073	18	transient	transient	JJ
cord-006860-a3b8hyyr	3073	19	BP	BP	NNP
cord-006860-a3b8hyyr	3073	20	-	-	HYPH
cord-006860-a3b8hyyr	3073	21	elevation	elevation	NN
cord-006860-a3b8hyyr	3073	22	and	and	CC
cord-006860-a3b8hyyr	3073	23	HR	hr	NN
cord-006860-a3b8hyyr	3073	24	-	-	HYPH
cord-006860-a3b8hyyr	3073	25	reduction	reduction	NN
cord-006860-a3b8hyyr	3073	26	.	.	.
cord-006860-a3b8hyyr	3074	1	Activation	activation	NN
cord-006860-a3b8hyyr	3074	2	of	of	IN
cord-006860-a3b8hyyr	3074	3	platelets	platelet	NNS
cord-006860-a3b8hyyr	3074	4	can	can	MD
cord-006860-a3b8hyyr	3074	5	be	be	VB
cord-006860-a3b8hyyr	3074	6	directly	directly	RB
cord-006860-a3b8hyyr	3074	7	measured	measure	VBN
cord-006860-a3b8hyyr	3074	8	by	by	IN
cord-006860-a3b8hyyr	3074	9	flow	flow	NN
cord-006860-a3b8hyyr	3074	10	cytometry	cytometry	NN
cord-006860-a3b8hyyr	3074	11	using	use	VBG
cord-006860-a3b8hyyr	3074	12	monoclunal	monoclunal	JJ
cord-006860-a3b8hyyr	3074	13	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3074	14	.	.	.
cord-006860-a3b8hyyr	3075	1	In	in	IN
cord-006860-a3b8hyyr	3075	2	an	an	DT
cord-006860-a3b8hyyr	3075	3	in	in	FW
cord-006860-a3b8hyyr	3075	4	vitro	vitro	FW
cord-006860-a3b8hyyr	3075	5	study	study	VB
cord-006860-a3b8hyyr	3075	6	the	the	DT
cord-006860-a3b8hyyr	3075	7	effect	effect	NN
cord-006860-a3b8hyyr	3075	8	of	of	IN
cord-006860-a3b8hyyr	3075	9	the	the	DT
cord-006860-a3b8hyyr	3075	10	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3075	11	inkibitors	inkibitors	NNP
cord-006860-a3b8hyyr	3075	12	argatroban	argatroban	NNP
cord-006860-a3b8hyyr	3075	13	,	,	,
cord-006860-a3b8hyyr	3075	14	efegatran	efegatran	NNP
cord-006860-a3b8hyyr	3075	15	,	,	,
cord-006860-a3b8hyyr	3075	16	DuP	DuP	VBZ
cord-006860-a3b8hyyr	3075	17	714	714	CD
cord-006860-a3b8hyyr	3075	18	,	,	,
cord-006860-a3b8hyyr	3075	19	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	3075	20	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3075	21	and	and	CC
cord-006860-a3b8hyyr	3075	22	PEGhirudin	peghirudin	NN
cord-006860-a3b8hyyr	3075	23	on	on	IN
cord-006860-a3b8hyyr	3075	24	platelet	platelet	NN
cord-006860-a3b8hyyr	3075	25	activation	activation	NN
cord-006860-a3b8hyyr	3075	26	induced	induce	VBN
cord-006860-a3b8hyyr	3075	27	by	by	IN
cord-006860-a3b8hyyr	3075	28	various	various	JJ
cord-006860-a3b8hyyr	3075	29	agonists	agonist	NNS
cord-006860-a3b8hyyr	3075	30	was	be	VBD
cord-006860-a3b8hyyr	3075	31	studied	study	VBN
cord-006860-a3b8hyyr	3075	32	in	in	IN
cord-006860-a3b8hyyr	3075	33	whole	whole	JJ
cord-006860-a3b8hyyr	3075	34	blood	blood	NN
cord-006860-a3b8hyyr	3075	35	.	.	.
cord-006860-a3b8hyyr	3076	1	Blood	blood	NN
cord-006860-a3b8hyyr	3076	2	was	be	VBD
cord-006860-a3b8hyyr	3076	3	drawn	draw	VBN
cord-006860-a3b8hyyr	3076	4	from	from	IN
cord-006860-a3b8hyyr	3076	5	normal	normal	JJ
cord-006860-a3b8hyyr	3076	6	human	human	JJ
cord-006860-a3b8hyyr	3076	7	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	3076	8	using	use	VBG
cord-006860-a3b8hyyr	3076	9	the	the	DT
cord-006860-a3b8hyyr	3076	10	double	double	JJ
cord-006860-a3b8hyyr	3076	11	syringe	syringe	NN
cord-006860-a3b8hyyr	3076	12	technique	technique	NN
cord-006860-a3b8hyyr	3076	13	without	without	IN
cord-006860-a3b8hyyr	3076	14	use	use	NN
cord-006860-a3b8hyyr	3076	15	of	of	IN
cord-006860-a3b8hyyr	3076	16	a	a	DT
cord-006860-a3b8hyyr	3076	17	tourniquet	tourniquet	NN
cord-006860-a3b8hyyr	3076	18	to	to	TO
cord-006860-a3b8hyyr	3076	19	avoid	avoid	VB
cord-006860-a3b8hyyr	3076	20	autoaggregatiun	autoaggregatiun	NNP
cord-006860-a3b8hyyr	3076	21	of	of	IN
cord-006860-a3b8hyyr	3076	22	platelets	platelet	NNS
cord-006860-a3b8hyyr	3076	23	.	.	.
cord-006860-a3b8hyyr	3077	1	For	for	IN
cord-006860-a3b8hyyr	3077	2	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3077	3	of	of	IN
cord-006860-a3b8hyyr	3077	4	blood	blood	NN
cord-006860-a3b8hyyr	3077	5	the	the	DT
cord-006860-a3b8hyyr	3077	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3077	7	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3077	8	mentioned	mention	VBN
cord-006860-a3b8hyyr	3077	9	above	above	RB
cord-006860-a3b8hyyr	3077	10	were	be	VBD
cord-006860-a3b8hyyr	3077	11	used	use	VBN
cord-006860-a3b8hyyr	3077	12	at	at	IN
cord-006860-a3b8hyyr	3077	13	a	a	DT
cord-006860-a3b8hyyr	3077	14	final	final	JJ
cord-006860-a3b8hyyr	3077	15	concentration	concentration	NN
cord-006860-a3b8hyyr	3077	16	of	of	IN
cord-006860-a3b8hyyr	3077	17	10	10	CD
cord-006860-a3b8hyyr	3078	1	~tg	~tg	NNP
cord-006860-a3b8hyyr	3078	2	/	/	SYM
cord-006860-a3b8hyyr	3078	3	ml	ml	XX
cord-006860-a3b8hyyr	3078	4	each	each	DT
cord-006860-a3b8hyyr	3078	5	.	.	.
cord-006860-a3b8hyyr	3079	1	Blood	blood	NN
cord-006860-a3b8hyyr	3079	2	samples	sample	NNS
cord-006860-a3b8hyyr	3079	3	were	be	VBD
cord-006860-a3b8hyyr	3079	4	then	then	RB
cord-006860-a3b8hyyr	3079	5	incubated	incubate	VBN
cord-006860-a3b8hyyr	3079	6	at	at	IN
cord-006860-a3b8hyyr	3079	7	37	37	CD
cord-006860-a3b8hyyr	3079	8	°	°	NN
cord-006860-a3b8hyyr	3079	9	C	c	NN
cord-006860-a3b8hyyr	3079	10	either	either	CC
cord-006860-a3b8hyyr	3079	11	with	with	IN
cord-006860-a3b8hyyr	3079	12	saline	saline	NN
cord-006860-a3b8hyyr	3079	13	,	,	,
cord-006860-a3b8hyyr	3079	14	r	r	NN
cord-006860-a3b8hyyr	3079	15	-	-	HYPH
cord-006860-a3b8hyyr	3079	16	tissue	tissue	NN
cord-006860-a3b8hyyr	3079	17	factor	factor	NN
cord-006860-a3b8hyyr	3079	18	(	(	-LRB-
cord-006860-a3b8hyyr	3079	19	rTF	rTF	NNP
cord-006860-a3b8hyyr	3079	20	)	)	-RRB-
cord-006860-a3b8hyyr	3079	21	,	,	,
cord-006860-a3b8hyyr	3079	22	arachidonic	arachidonic	JJ
cord-006860-a3b8hyyr	3079	23	acid	acid	NN
cord-006860-a3b8hyyr	3079	24	(	(	-LRB-
cord-006860-a3b8hyyr	3079	25	AA	AA	NNP
cord-006860-a3b8hyyr	3079	26	)	)	-RRB-
cord-006860-a3b8hyyr	3079	27	,	,	,
cord-006860-a3b8hyyr	3079	28	adenosine	adenosine	NN
cord-006860-a3b8hyyr	3079	29	diphosphate	diphosphate	NN
cord-006860-a3b8hyyr	3079	30	(	(	-LRB-
cord-006860-a3b8hyyr	3079	31	ADP	ADP	NNP
cord-006860-a3b8hyyr	3079	32	)	)	-RRB-
cord-006860-a3b8hyyr	3079	33	or	or	CC
cord-006860-a3b8hyyr	3079	34	collagen	collagen	NN
cord-006860-a3b8hyyr	3079	35	.	.	.
cord-006860-a3b8hyyr	3080	1	At	at	IN
cord-006860-a3b8hyyr	3080	2	definite	definite	JJ
cord-006860-a3b8hyyr	3080	3	times	time	NNS
cord-006860-a3b8hyyr	3080	4	(	(	-LRB-
cord-006860-a3b8hyyr	3080	5	1	1	CD
cord-006860-a3b8hyyr	3080	6	,	,	,
cord-006860-a3b8hyyr	3080	7	2.5	2.5	CD
cord-006860-a3b8hyyr	3080	8	,	,	,
cord-006860-a3b8hyyr	3080	9	5	5	CD
cord-006860-a3b8hyyr	3080	10	,	,	,
cord-006860-a3b8hyyr	3080	11	10	10	CD
cord-006860-a3b8hyyr	3080	12	rain	rain	NN
cord-006860-a3b8hyyr	3080	13	)	)	-RRB-
cord-006860-a3b8hyyr	3080	14	aliquots	aliquot	NNS
cord-006860-a3b8hyyr	3080	15	were	be	VBD
cord-006860-a3b8hyyr	3080	16	taken	take	VBN
cord-006860-a3b8hyyr	3080	17	and	and	CC
cord-006860-a3b8hyyr	3080	18	after	after	IN
cord-006860-a3b8hyyr	3080	19	various	various	JJ
cord-006860-a3b8hyyr	3080	20	steps	step	NNS
cord-006860-a3b8hyyr	3080	21	of	of	IN
cord-006860-a3b8hyyr	3080	22	fixative	fixative	NN
cord-006860-a3b8hyyr	3080	23	procedure	procedure	NN
cord-006860-a3b8hyyr	3080	24	the	the	DT
cord-006860-a3b8hyyr	3080	25	percentage	percentage	NN
cord-006860-a3b8hyyr	3080	26	of	of	IN
cord-006860-a3b8hyyr	3080	27	platelet	platelet	NN
cord-006860-a3b8hyyr	3080	28	activation	activation	NN
cord-006860-a3b8hyyr	3080	29	was	be	VBD
cord-006860-a3b8hyyr	3080	30	measured	measure	VBN
cord-006860-a3b8hyyr	3080	31	by	by	IN
cord-006860-a3b8hyyr	3080	32	means	mean	NNS
cord-006860-a3b8hyyr	3080	33	of	of	IN
cord-006860-a3b8hyyr	3080	34	fluorescent	fluorescent	JJ
cord-006860-a3b8hyyr	3080	35	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	3080	36	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3080	37	to	to	IN
cord-006860-a3b8hyyr	3080	38	platelet	platelet	NN
cord-006860-a3b8hyyr	3080	39	surface	surface	NN
cord-006860-a3b8hyyr	3080	40	receptors	receptor	NNS
cord-006860-a3b8hyyr	3080	41	GPIIIa	GPIIIa	NNS
cord-006860-a3b8hyyr	3080	42	(	(	-LRB-
cord-006860-a3b8hyyr	3080	43	CD-61	CD-61	NNP
cord-006860-a3b8hyyr	3080	44	)	)	-RRB-
cord-006860-a3b8hyyr	3080	45	and	and	CC
cord-006860-a3b8hyyr	3080	46	P	p	NN
cord-006860-a3b8hyyr	3080	47	-	-	HYPH
cord-006860-a3b8hyyr	3080	48	selectin	selectin	NNP
cord-006860-a3b8hyyr	3080	49	(	(	-LRB-
cord-006860-a3b8hyyr	3080	50	CD-62	CD-62	NNP
cord-006860-a3b8hyyr	3080	51	)	)	-RRB-
cord-006860-a3b8hyyr	3080	52	.	.	.
cord-006860-a3b8hyyr	3081	1	The	the	DT
cord-006860-a3b8hyyr	3081	2	agunists	agunist	NNS
cord-006860-a3b8hyyr	3081	3	used	use	VBN
cord-006860-a3b8hyyr	3081	4	induced	induce	VBN
cord-006860-a3b8hyyr	3081	5	a	a	DT
cord-006860-a3b8hyyr	3081	6	platelet	platelet	NN
cord-006860-a3b8hyyr	3081	7	activation	activation	NN
cord-006860-a3b8hyyr	3081	8	of	of	IN
cord-006860-a3b8hyyr	3081	9	37.4	37.4	CD
cord-006860-a3b8hyyr	3081	10	+	+	SYM
cord-006860-a3b8hyyr	3081	11	15.2	15.2	CD
cord-006860-a3b8hyyr	3081	12	%	%	NN
cord-006860-a3b8hyyr	3081	13	(	(	-LRB-
cord-006860-a3b8hyyr	3081	14	rTF	rTF	NNP
cord-006860-a3b8hyyr	3081	15	)	)	-RRB-
cord-006860-a3b8hyyr	3081	16	,	,	,
cord-006860-a3b8hyyr	3081	17	65.1	65.1	CD
cord-006860-a3b8hyyr	3081	18	+	+	SYM
cord-006860-a3b8hyyr	3081	19	12.1	12.1	CD
cord-006860-a3b8hyyr	3081	20	%	%	NN
cord-006860-a3b8hyyr	3081	21	(	(	-LRB-
cord-006860-a3b8hyyr	3081	22	AA	AA	NNP
cord-006860-a3b8hyyr	3081	23	)	)	-RRB-
cord-006860-a3b8hyyr	3081	24	,	,	,
cord-006860-a3b8hyyr	3081	25	19.3	19.3	CD
cord-006860-a3b8hyyr	3081	26	+	+	SYM
cord-006860-a3b8hyyr	3081	27	7.4	7.4	CD
cord-006860-a3b8hyyr	3081	28	%	%	NN
cord-006860-a3b8hyyr	3081	29	(	(	-LRB-
cord-006860-a3b8hyyr	3081	30	ADP	ADP	NNP
cord-006860-a3b8hyyr	3081	31	)	)	-RRB-
cord-006860-a3b8hyyr	3081	32	and	and	CC
cord-006860-a3b8hyyr	3081	33	27.1	27.1	CD
cord-006860-a3b8hyyr	3081	34	+	+	SYM
cord-006860-a3b8hyyr	3081	35	12.8	12.8	CD
cord-006860-a3b8hyyr	3081	36	%	%	NN
cord-006860-a3b8hyyr	3081	37	(	(	-LRB-
cord-006860-a3b8hyyr	3081	38	collagen	collagen	NNP
cord-006860-a3b8hyyr	3081	39	)	)	-RRB-
cord-006860-a3b8hyyr	3081	40	.	.	.
cord-006860-a3b8hyyr	3082	1	Flow	flow	VB
cord-006860-a3b8hyyr	3082	2	cytometric	cytometric	NN
cord-006860-a3b8hyyr	3082	3	analysis	analysis	NN
cord-006860-a3b8hyyr	3082	4	showed	show	VBD
cord-006860-a3b8hyyr	3082	5	that	that	IN
cord-006860-a3b8hyyr	3082	6	all	all	DT
cord-006860-a3b8hyyr	3082	7	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3082	8	inlaibitors	inlaibitor	NNS
cord-006860-a3b8hyyr	3082	9	studied	study	VBD
cord-006860-a3b8hyyr	3082	10	caused	cause	VBD
cord-006860-a3b8hyyr	3082	11	a	a	DT
cord-006860-a3b8hyyr	3082	12	nearly	nearly	RB
cord-006860-a3b8hyyr	3082	13	complete	complete	JJ
cord-006860-a3b8hyyr	3082	14	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3082	15	of	of	IN
cord-006860-a3b8hyyr	3082	16	r	r	NN
cord-006860-a3b8hyyr	3082	17	-	-	HYPH
cord-006860-a3b8hyyr	3082	18	tissue	tissue	NN
cord-006860-a3b8hyyr	3082	19	factor	factor	NN
cord-006860-a3b8hyyr	3082	20	-	-	HYPH
cord-006860-a3b8hyyr	3082	21	mediated	mediate	VBN
cord-006860-a3b8hyyr	3082	22	platelet	platelet	NN
cord-006860-a3b8hyyr	3082	23	activation	activation	NN
cord-006860-a3b8hyyr	3082	24	.	.	.
cord-006860-a3b8hyyr	3083	1	In	in	IN
cord-006860-a3b8hyyr	3083	2	contrast	contrast	NN
cord-006860-a3b8hyyr	3083	3	,	,	,
cord-006860-a3b8hyyr	3083	4	after	after	IN
cord-006860-a3b8hyyr	3083	5	induction	induction	NN
cord-006860-a3b8hyyr	3083	6	of	of	IN
cord-006860-a3b8hyyr	3083	7	platelet	platelet	NN
cord-006860-a3b8hyyr	3083	8	activation	activation	NN
cord-006860-a3b8hyyr	3083	9	with	with	IN
cord-006860-a3b8hyyr	3083	10	the	the	DT
cord-006860-a3b8hyyr	3083	11	other	other	JJ
cord-006860-a3b8hyyr	3083	12	agonists	agonist	NNS
cord-006860-a3b8hyyr	3083	13	an	an	DT
cord-006860-a3b8hyyr	3083	14	increased	increase	VBN
cord-006860-a3b8hyyr	3083	15	percent	percent	NN
cord-006860-a3b8hyyr	3083	16	CD-62	CD-62	NNP
cord-006860-a3b8hyyr	3083	17	expression	expression	NN
cord-006860-a3b8hyyr	3083	18	was	be	VBD
cord-006860-a3b8hyyr	3083	19	found	find	VBN
cord-006860-a3b8hyyr	3083	20	showing	show	VBG
cord-006860-a3b8hyyr	3083	21	a	a	DT
cord-006860-a3b8hyyr	3083	22	strong	strong	JJ
cord-006860-a3b8hyyr	3083	23	platelet	platelet	NN
cord-006860-a3b8hyyr	3083	24	activation	activation	NN
cord-006860-a3b8hyyr	3083	25	with	with	IN
cord-006860-a3b8hyyr	3083	26	a	a	DT
cord-006860-a3b8hyyr	3083	27	maximum	maximum	NN
cord-006860-a3b8hyyr	3083	28	at	at	IN
cord-006860-a3b8hyyr	3083	29	the	the	DT
cord-006860-a3b8hyyr	3083	30	same	same	JJ
cord-006860-a3b8hyyr	3083	31	times	time	NNS
cord-006860-a3b8hyyr	3083	32	as	as	IN
cord-006860-a3b8hyyr	3083	33	in	in	IN
cord-006860-a3b8hyyr	3083	34	non	non	JJ
cord-006860-a3b8hyyr	3083	35	-	-	JJ
cord-006860-a3b8hyyr	3083	36	anticoagulated	anticoagulated	JJ
cord-006860-a3b8hyyr	3083	37	blood	blood	NN
cord-006860-a3b8hyyr	3083	38	.	.	.
cord-006860-a3b8hyyr	3084	1	In	in	IN
cord-006860-a3b8hyyr	3084	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	3084	3	,	,	,
cord-006860-a3b8hyyr	3084	4	the	the	DT
cord-006860-a3b8hyyr	3084	5	results	result	NNS
cord-006860-a3b8hyyr	3084	6	show	show	VBP
cord-006860-a3b8hyyr	3084	7	that	that	IN
cord-006860-a3b8hyyr	3084	8	in	in	IN
cord-006860-a3b8hyyr	3084	9	whole	whole	JJ
cord-006860-a3b8hyyr	3084	10	blood	blood	NN
cord-006860-a3b8hyyr	3085	1	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3085	2	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3085	3	are	be	VBP
cord-006860-a3b8hyyr	3085	4	effective	effective	JJ
cord-006860-a3b8hyyr	3085	5	in	in	IN
cord-006860-a3b8hyyr	3085	6	preventing	prevent	VBG
cord-006860-a3b8hyyr	3085	7	platelet	platelet	NN
cord-006860-a3b8hyyr	3085	8	activation	activation	NN
cord-006860-a3b8hyyr	3085	9	induced	induce	VBN
cord-006860-a3b8hyyr	3085	10	by	by	IN
cord-006860-a3b8hyyr	3085	11	r	r	NN
cord-006860-a3b8hyyr	3085	12	-	-	HYPH
cord-006860-a3b8hyyr	3085	13	tissue	tissue	NN
cord-006860-a3b8hyyr	3085	14	factor	factor	NN
cord-006860-a3b8hyyr	3085	15	.	.	.
cord-006860-a3b8hyyr	3086	1	The	the	DT
cord-006860-a3b8hyyr	3086	2	formation	formation	NN
cord-006860-a3b8hyyr	3086	3	of	of	IN
cord-006860-a3b8hyyr	3086	4	active	active	JJ
cord-006860-a3b8hyyr	3086	5	serine	serine	NN
cord-006860-a3b8hyyr	3086	6	proteases	protease	NNS
cord-006860-a3b8hyyr	3086	7	including	include	VBG
cord-006860-a3b8hyyr	3086	8	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3086	9	may	may	MD
cord-006860-a3b8hyyr	3086	10	be	be	VB
cord-006860-a3b8hyyr	3086	11	effectively	effectively	RB
cord-006860-a3b8hyyr	3086	12	inldbked	inldbke	VBN
cord-006860-a3b8hyyr	3086	13	by	by	IN
cord-006860-a3b8hyyr	3086	14	these	these	DT
cord-006860-a3b8hyyr	3086	15	agents	agent	NNS
cord-006860-a3b8hyyr	3086	16	.	.	.
cord-006860-a3b8hyyr	3087	1	The	the	DT
cord-006860-a3b8hyyr	3087	2	observations	observation	NNS
cord-006860-a3b8hyyr	3087	3	further	further	RB
cord-006860-a3b8hyyr	3087	4	suggest	suggest	VBP
cord-006860-a3b8hyyr	3087	5	that	that	IN
cord-006860-a3b8hyyr	3087	6	,	,	,
cord-006860-a3b8hyyr	3087	7	while	while	IN
cord-006860-a3b8hyyr	3087	8	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3087	9	inkibitors	inkibitor	NNS
cord-006860-a3b8hyyr	3087	10	may	may	MD
cord-006860-a3b8hyyr	3087	11	control	control	VB
cord-006860-a3b8hyyr	3087	12	serine	serine	NN
cord-006860-a3b8hyyr	3087	13	proteases	protease	NNS
cord-006860-a3b8hyyr	3087	14	,	,	,
cord-006860-a3b8hyyr	3087	15	these	these	DT
cord-006860-a3b8hyyr	3087	16	agents	agent	NNS
cord-006860-a3b8hyyr	3087	17	do	do	VBP
cord-006860-a3b8hyyr	3087	18	not	not	RB
cord-006860-a3b8hyyr	3087	19	inhibit	inhibit	VB
cord-006860-a3b8hyyr	3087	20	the	the	DT
cord-006860-a3b8hyyr	3087	21	activation	activation	NN
cord-006860-a3b8hyyr	3087	22	ofplatelets	ofplatelet	NNS
cord-006860-a3b8hyyr	3087	23	mediated	mediate	VBN
cord-006860-a3b8hyyr	3087	24	by	by	IN
cord-006860-a3b8hyyr	3087	25	other	other	JJ
cord-006860-a3b8hyyr	3087	26	agonists	agonist	NNS
cord-006860-a3b8hyyr	3087	27	.	.	.
cord-006860-a3b8hyyr	3088	1	This	this	DT
cord-006860-a3b8hyyr	3088	2	work	work	NN
cord-006860-a3b8hyyr	3088	3	was	be	VBD
cord-006860-a3b8hyyr	3088	4	supported	support	VBN
cord-006860-a3b8hyyr	3088	5	by	by	IN
cord-006860-a3b8hyyr	3088	6	the	the	DT
cord-006860-a3b8hyyr	3088	7	grant	grant	NN
cord-006860-a3b8hyyr	3088	8	BMFT	BMFT	NNP
cord-006860-a3b8hyyr	3088	9	07NBL01	07nbl01	CD
cord-006860-a3b8hyyr	3088	10	.	.	.
cord-006860-a3b8hyyr	3089	1	ANIMAL	animal	NN
cord-006860-a3b8hyyr	3089	2	EXPERIMENTAL	EXPERIMENTAL	NNP
cord-006860-a3b8hyyr	3089	3	STUDIES	study	NNS
cord-006860-a3b8hyyr	3089	4	ON	on	IN
cord-006860-a3b8hyyr	3089	5	THE	the	DT
cord-006860-a3b8hyyr	3089	6	PHARMACOKINETICS	PHARMACOKINETICS	NNP
cord-006860-a3b8hyyr	3089	7	OF	of	IN
cord-006860-a3b8hyyr	3089	8	PEG	PEG	NNP
cord-006860-a3b8hyyr	3089	9	-	-	HYPH
cord-006860-a3b8hyyr	3089	10	HIRUDIN	HIRUDIN	NNP
cord-006860-a3b8hyyr	3089	11	E.	E.	NNP
cord-006860-a3b8hyyr	3089	12	Bucha	Bucha	NNP
cord-006860-a3b8hyyr	3089	13	,	,	,
cord-006860-a3b8hyyr	3089	14	A.	A.	NNP
cord-006860-a3b8hyyr	3089	15	Kossmehl	Kossmehl	NNP
cord-006860-a3b8hyyr	3089	16	,	,	,
cord-006860-a3b8hyyr	3089	17	G.	G.	NNP
cord-006860-a3b8hyyr	3089	18	Nowak	Nowak	NNP
cord-006860-a3b8hyyr	3089	19	Max	Max	NNP
cord-006860-a3b8hyyr	3089	20	-	-	HYPH
cord-006860-a3b8hyyr	3089	21	PIanck	PIanck	NNP
cord-006860-a3b8hyyr	3089	22	-	-	HYPH
cord-006860-a3b8hyyr	3089	23	Gesellschaft	Gesellschaft	NNP
cord-006860-a3b8hyyr	3089	24	e.	e.	NNP
cord-006860-a3b8hyyr	3089	25	V.	V.	NNP
cord-006860-a3b8hyyr	3089	26	,	,	,
cord-006860-a3b8hyyr	3090	1	Arbeitsgruppe	Arbeitsgruppe	NNP
cord-006860-a3b8hyyr	3090	2	"	"	``
cord-006860-a3b8hyyr	3090	3	Pharmakologische	Pharmakologische	NNP
cord-006860-a3b8hyyr	3090	4	H	H	NNP
cord-006860-a3b8hyyr	3090	5	~	~	NFP
cord-006860-a3b8hyyr	3090	6	imostaseologie	imostaseologie	NN
cord-006860-a3b8hyyr	3090	7	"	"	''
cord-006860-a3b8hyyr	3090	8	,	,	,
cord-006860-a3b8hyyr	3090	9	Jena	Jena	NNP
cord-006860-a3b8hyyr	3090	10	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3090	11	,	,	,
cord-006860-a3b8hyyr	3090	12	when	when	WRB
cord-006860-a3b8hyyr	3090	13	complexed	complexe	VBN
cord-006860-a3b8hyyr	3090	14	with	with	IN
cord-006860-a3b8hyyr	3090	15	polyethylene	polyethylene	NN
cord-006860-a3b8hyyr	3090	16	glycol	glycol	NN
cord-006860-a3b8hyyr	3090	17	(	(	-LRB-
cord-006860-a3b8hyyr	3090	18	PEG	PEG	NNP
cord-006860-a3b8hyyr	3090	19	)	)	-RRB-
cord-006860-a3b8hyyr	3090	20	,	,	,
cord-006860-a3b8hyyr	3090	21	increases	increase	VBZ
cord-006860-a3b8hyyr	3090	22	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3090	23	molecular	molecular	JJ
cord-006860-a3b8hyyr	3090	24	weight	weight	NN
cord-006860-a3b8hyyr	3090	25	from	from	IN
cord-006860-a3b8hyyr	3090	26	7	7	CD
cord-006860-a3b8hyyr	3090	27	to	to	IN
cord-006860-a3b8hyyr	3090	28	17	17	CD
cord-006860-a3b8hyyr	3090	29	kDa	kDa	NNS
cord-006860-a3b8hyyr	3090	30	,	,	,
cord-006860-a3b8hyyr	3090	31	thereby	thereby	RB
cord-006860-a3b8hyyr	3090	32	preventing	prevent	VBG
cord-006860-a3b8hyyr	3090	33	extravasation	extravasation	NN
cord-006860-a3b8hyyr	3090	34	of	of	IN
cord-006860-a3b8hyyr	3090	35	this	this	DT
cord-006860-a3b8hyyr	3090	36	drug	drug	NN
cord-006860-a3b8hyyr	3090	37	.	.	.
cord-006860-a3b8hyyr	3091	1	PEG	peg	NN
cord-006860-a3b8hyyr	3091	2	-	-	HYPH
cord-006860-a3b8hyyr	3091	3	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3091	4	is	be	VBZ
cord-006860-a3b8hyyr	3091	5	distributed	distribute	VBN
cord-006860-a3b8hyyr	3091	6	almost	almost	RB
cord-006860-a3b8hyyr	3091	7	only	only	RB
cord-006860-a3b8hyyr	3091	8	in	in	IN
cord-006860-a3b8hyyr	3091	9	the	the	DT
cord-006860-a3b8hyyr	3091	10	intravascular	intravascular	JJ
cord-006860-a3b8hyyr	3091	11	blood	blood	NN
cord-006860-a3b8hyyr	3091	12	space	space	NN
cord-006860-a3b8hyyr	3091	13	.	.	.
cord-006860-a3b8hyyr	3092	1	In	in	IN
cord-006860-a3b8hyyr	3092	2	addition	addition	NN
cord-006860-a3b8hyyr	3092	3	,	,	,
cord-006860-a3b8hyyr	3092	4	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3092	5	increased	increase	VBN
cord-006860-a3b8hyyr	3092	6	molecular	molecular	JJ
cord-006860-a3b8hyyr	3092	7	weight	weight	NN
cord-006860-a3b8hyyr	3092	8	retards	retard	VBZ
cord-006860-a3b8hyyr	3092	9	the	the	DT
cord-006860-a3b8hyyr	3092	10	renal	renal	JJ
cord-006860-a3b8hyyr	3092	11	elimination	elimination	NN
cord-006860-a3b8hyyr	3092	12	.	.	.
cord-006860-a3b8hyyr	3093	1	The	the	DT
cord-006860-a3b8hyyr	3093	2	elimination	elimination	NN
cord-006860-a3b8hyyr	3093	3	half	half	JJ
cord-006860-a3b8hyyr	3093	4	-	-	HYPH
cord-006860-a3b8hyyr	3093	5	life	life	NN
cord-006860-a3b8hyyr	3093	6	of	of	IN
cord-006860-a3b8hyyr	3093	7	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3093	8	in	in	IN
cord-006860-a3b8hyyr	3093	9	rats	rat	NNS
cord-006860-a3b8hyyr	3093	10	(	(	-LRB-
cord-006860-a3b8hyyr	3093	11	58	58	CD
cord-006860-a3b8hyyr	3093	12	+	+	SYM
cord-006860-a3b8hyyr	3093	13	12	12	CD
cord-006860-a3b8hyyr	3093	14	min	min	NN
cord-006860-a3b8hyyr	3093	15	,	,	,
cord-006860-a3b8hyyr	3093	16	as	as	IN
cord-006860-a3b8hyyr	3093	17	determined	determine	VBN
cord-006860-a3b8hyyr	3093	18	)	)	-RRB-
cord-006860-a3b8hyyr	3093	19	is	be	VBZ
cord-006860-a3b8hyyr	3093	20	increased	increase	VBN
cord-006860-a3b8hyyr	3093	21	five	five	CD
cord-006860-a3b8hyyr	3093	22	-	-	RB
cord-006860-a3b8hyyr	3093	23	fold	fold	JJ
cord-006860-a3b8hyyr	3093	24	(	(	-LRB-
cord-006860-a3b8hyyr	3093	25	244	244	CD
cord-006860-a3b8hyyr	3093	26	±	±	CD
cord-006860-a3b8hyyr	3093	27	18	18	CD
cord-006860-a3b8hyyr	3093	28	min	min	NNP
cord-006860-a3b8hyyr	3093	29	)	)	-RRB-
cord-006860-a3b8hyyr	3093	30	.	.	.
cord-006860-a3b8hyyr	3094	1	With	with	IN
cord-006860-a3b8hyyr	3094	2	the	the	DT
cord-006860-a3b8hyyr	3094	3	same	same	JJ
cord-006860-a3b8hyyr	3094	4	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3094	5	dose	dose	NN
cord-006860-a3b8hyyr	3094	6	applied	apply	VBD
cord-006860-a3b8hyyr	3094	7	,	,	,
cord-006860-a3b8hyyr	3094	8	the	the	DT
cord-006860-a3b8hyyr	3094	9	blood	blood	NN
cord-006860-a3b8hyyr	3094	10	level	level	NN
cord-006860-a3b8hyyr	3094	11	of	of	IN
cord-006860-a3b8hyyr	3094	12	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3094	13	is	be	VBZ
cord-006860-a3b8hyyr	3094	14	increased	increase	VBN
cord-006860-a3b8hyyr	3094	15	19-fold	19-fold	CD
cord-006860-a3b8hyyr	3094	16	,	,	,
cord-006860-a3b8hyyr	3094	17	measured	measure	VBN
cord-006860-a3b8hyyr	3094	18	in	in	IN
cord-006860-a3b8hyyr	3094	19	the	the	DT
cord-006860-a3b8hyyr	3094	20	13-elimination	13-elimination	CD
cord-006860-a3b8hyyr	3094	21	phase	phase	NN
cord-006860-a3b8hyyr	3094	22	.	.	.
cord-006860-a3b8hyyr	3095	1	In	in	IN
cord-006860-a3b8hyyr	3095	2	the	the	DT
cord-006860-a3b8hyyr	3095	3	urine	urine	NN
cord-006860-a3b8hyyr	3095	4	of	of	IN
cord-006860-a3b8hyyr	3095	5	rats	rat	NNS
cord-006860-a3b8hyyr	3095	6	,	,	,
cord-006860-a3b8hyyr	3095	7	2	2	CD
cord-006860-a3b8hyyr	3095	8	-3	-3	CD
cord-006860-a3b8hyyr	3095	9	%	%	NN
cord-006860-a3b8hyyr	3095	10	of	of	IN
cord-006860-a3b8hyyr	3095	11	the	the	DT
cord-006860-a3b8hyyr	3095	12	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3095	13	activity	activity	NN
cord-006860-a3b8hyyr	3095	14	were	be	VBD
cord-006860-a3b8hyyr	3095	15	recovered	recover	VBN
cord-006860-a3b8hyyr	3095	16	following	follow	VBG
cord-006860-a3b8hyyr	3095	17	hirudin	hirudin	NNP
cord-006860-a3b8hyyr	3095	18	administration	administration	NN
cord-006860-a3b8hyyr	3095	19	,	,	,
cord-006860-a3b8hyyr	3095	20	but	but	CC
cord-006860-a3b8hyyr	3095	21	48	48	CD
cord-006860-a3b8hyyr	3095	22	%	%	NN
cord-006860-a3b8hyyr	3095	23	could	could	MD
cord-006860-a3b8hyyr	3095	24	be	be	VB
cord-006860-a3b8hyyr	3095	25	detected	detect	VBN
cord-006860-a3b8hyyr	3095	26	after	after	IN
cord-006860-a3b8hyyr	3095	27	PEG	peg	NN
cord-006860-a3b8hyyr	3095	28	-	-	HYPH
cord-006860-a3b8hyyr	3095	29	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3095	30	had	have	VBD
cord-006860-a3b8hyyr	3095	31	been	be	VBN
cord-006860-a3b8hyyr	3095	32	applied	apply	VBN
cord-006860-a3b8hyyr	3095	33	.	.	.
cord-006860-a3b8hyyr	3096	1	After	after	IN
cord-006860-a3b8hyyr	3096	2	subcutaneous	subcutaneous	JJ
cord-006860-a3b8hyyr	3096	3	administration	administration	NN
cord-006860-a3b8hyyr	3096	4	of	of	IN
cord-006860-a3b8hyyr	3096	5	PEG	peg	NN
cord-006860-a3b8hyyr	3096	6	-	-	HYPH
cord-006860-a3b8hyyr	3096	7	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3096	8	,	,	,
cord-006860-a3b8hyyr	3096	9	the	the	DT
cord-006860-a3b8hyyr	3096	10	trnaxwalue	trnaxwalue	NNP
cord-006860-a3b8hyyr	3096	11	is	be	VBZ
cord-006860-a3b8hyyr	3096	12	reached	reach	VBN
cord-006860-a3b8hyyr	3096	13	at	at	IN
cord-006860-a3b8hyyr	3096	14	380	380	CD
cord-006860-a3b8hyyr	3096	15	rain	rain	NN
cord-006860-a3b8hyyr	3096	16	(	(	-LRB-
cord-006860-a3b8hyyr	3096	17	r	r	NN
cord-006860-a3b8hyyr	3096	18	-	-	HYPH
cord-006860-a3b8hyyr	3096	19	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3096	20	:	:	:
cord-006860-a3b8hyyr	3096	21	65	65	CD
cord-006860-a3b8hyyr	3096	22	min	min	NN
cord-006860-a3b8hyyr	3096	23	)	)	-RRB-
cord-006860-a3b8hyyr	3096	24	;	;	:
cord-006860-a3b8hyyr	3096	25	the	the	DT
cord-006860-a3b8hyyr	3096	26	Cmax	Cmax	NNP
cord-006860-a3b8hyyr	3096	27	-	-	HYPH
cord-006860-a3b8hyyr	3096	28	value	value	NN
cord-006860-a3b8hyyr	3096	29	is	be	VBZ
cord-006860-a3b8hyyr	3096	30	increased	increase	VBN
cord-006860-a3b8hyyr	3096	31	3-fold	3-fold	CD
cord-006860-a3b8hyyr	3096	32	,	,	,
cord-006860-a3b8hyyr	3096	33	compared	compare	VBN
cord-006860-a3b8hyyr	3096	34	to	to	IN
cord-006860-a3b8hyyr	3096	35	that	that	DT
cord-006860-a3b8hyyr	3096	36	of	of	IN
cord-006860-a3b8hyyr	3096	37	r	r	NN
cord-006860-a3b8hyyr	3096	38	-	-	:
cord-006860-a3b8hyyr	3096	39	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3096	40	(	(	-LRB-
cord-006860-a3b8hyyr	3096	41	2.5	2.5	CD
cord-006860-a3b8hyyr	3096	42	pg	pg	NN
cord-006860-a3b8hyyr	3096	43	/	/	SYM
cord-006860-a3b8hyyr	3096	44	ml	ml	NNP
cord-006860-a3b8hyyr	3096	45	)	)	-RRB-
cord-006860-a3b8hyyr	3096	46	.	.	.
cord-006860-a3b8hyyr	3097	1	24	24	CD
cord-006860-a3b8hyyr	3097	2	hours	hour	NNS
cord-006860-a3b8hyyr	3097	3	later	later	RB
cord-006860-a3b8hyyr	3097	4	,	,	,
cord-006860-a3b8hyyr	3097	5	still	still	RB
cord-006860-a3b8hyyr	3097	6	one	one	CD
cord-006860-a3b8hyyr	3097	7	fifth	fifth	NN
cord-006860-a3b8hyyr	3097	8	of	of	IN
cord-006860-a3b8hyyr	3097	9	the	the	DT
cord-006860-a3b8hyyr	3097	10	maximum	maximum	JJ
cord-006860-a3b8hyyr	3097	11	concentration	concentration	NN
cord-006860-a3b8hyyr	3097	12	(	(	-LRB-
cord-006860-a3b8hyyr	3097	13	Cma	Cma	NNP
cord-006860-a3b8hyyr	3097	14	,	,	,
cord-006860-a3b8hyyr	3097	15	)	)	-RRB-
cord-006860-a3b8hyyr	3097	16	is	be	VBZ
cord-006860-a3b8hyyr	3097	17	present	present	JJ
cord-006860-a3b8hyyr	3097	18	in	in	IN
cord-006860-a3b8hyyr	3097	19	the	the	DT
cord-006860-a3b8hyyr	3097	20	blood	blood	NN
cord-006860-a3b8hyyr	3097	21	,	,	,
cord-006860-a3b8hyyr	3097	22	and	and	CC
cord-006860-a3b8hyyr	3097	23	the	the	DT
cord-006860-a3b8hyyr	3097	24	renal	renal	JJ
cord-006860-a3b8hyyr	3097	25	elimination	elimination	NN
cord-006860-a3b8hyyr	3097	26	is	be	VBZ
cord-006860-a3b8hyyr	3097	27	still	still	RB
cord-006860-a3b8hyyr	3097	28	retarded	retarded	JJ
cord-006860-a3b8hyyr	3097	29	.	.	.
cord-006860-a3b8hyyr	3098	1	In	in	IN
cord-006860-a3b8hyyr	3098	2	the	the	DT
cord-006860-a3b8hyyr	3098	3	urine	urine	NN
cord-006860-a3b8hyyr	3098	4	of	of	IN
cord-006860-a3b8hyyr	3098	5	rats	rat	NNS
cord-006860-a3b8hyyr	3098	6	,	,	,
cord-006860-a3b8hyyr	3098	7	12	12	CD
cord-006860-a3b8hyyr	3098	8	%	%	NN
cord-006860-a3b8hyyr	3098	9	of	of	IN
cord-006860-a3b8hyyr	3098	10	the	the	DT
cord-006860-a3b8hyyr	3098	11	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3098	12	activity	activity	NN
cord-006860-a3b8hyyr	3098	13	applied	apply	VBN
cord-006860-a3b8hyyr	3098	14	were	be	VBD
cord-006860-a3b8hyyr	3098	15	recovered	recover	VBN
cord-006860-a3b8hyyr	3098	16	in	in	IN
cord-006860-a3b8hyyr	3098	17	the	the	DT
cord-006860-a3b8hyyr	3098	18	24-h	24-h	JJ
cord-006860-a3b8hyyr	3098	19	urine	urine	NN
cord-006860-a3b8hyyr	3098	20	sample	sample	NN
cord-006860-a3b8hyyr	3098	21	.	.	.
cord-006860-a3b8hyyr	3099	1	With	with	IN
cord-006860-a3b8hyyr	3099	2	intact	intact	JJ
cord-006860-a3b8hyyr	3099	3	renal	renal	JJ
cord-006860-a3b8hyyr	3099	4	function	function	NN
cord-006860-a3b8hyyr	3099	5	,	,	,
cord-006860-a3b8hyyr	3099	6	following	follow	VBG
cord-006860-a3b8hyyr	3099	7	subcutaneous	subcutaneous	JJ
cord-006860-a3b8hyyr	3099	8	administration	administration	NN
cord-006860-a3b8hyyr	3099	9	,	,	,
cord-006860-a3b8hyyr	3099	10	PEGhirudin	PEGhirudin	NNP
cord-006860-a3b8hyyr	3099	11	is	be	VBZ
cord-006860-a3b8hyyr	3099	12	abte	abte	VBN
cord-006860-a3b8hyyr	3099	13	to	to	TO
cord-006860-a3b8hyyr	3099	14	produce	produce	VB
cord-006860-a3b8hyyr	3099	15	a	a	DT
cord-006860-a3b8hyyr	3099	16	constant	constant	JJ
cord-006860-a3b8hyyr	3099	17	blood	blood	NN
cord-006860-a3b8hyyr	3099	18	level	level	NN
cord-006860-a3b8hyyr	3099	19	of	of	IN
cord-006860-a3b8hyyr	3099	20	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3099	21	over	over	IN
cord-006860-a3b8hyyr	3099	22	a	a	DT
cord-006860-a3b8hyyr	3099	23	long	long	JJ
cord-006860-a3b8hyyr	3099	24	pedod	pedod	NN
cord-006860-a3b8hyyr	3099	25	.	.	.
cord-006860-a3b8hyyr	3100	1	Thrombin	Thrombin	NNP
cord-006860-a3b8hyyr	3100	2	inkibitors	inkibitor	NNS
cord-006860-a3b8hyyr	3100	3	such	such	JJ
cord-006860-a3b8hyyr	3100	4	as	as	IN
cord-006860-a3b8hyyr	3100	5	r	r	NN
cord-006860-a3b8hyyr	3100	6	-	-	:
cord-006860-a3b8hyyr	3100	7	hirudin	hirudin	JJ
cord-006860-a3b8hyyr	3100	8	(	(	-LRB-
cord-006860-a3b8hyyr	3100	9	RH	RH	NNP
cord-006860-a3b8hyyr	3100	10	)	)	-RRB-
cord-006860-a3b8hyyr	3100	11	,	,	,
cord-006860-a3b8hyyr	3100	12	argatroban	argatroban	NNP
cord-006860-a3b8hyyr	3100	13	(	(	-LRB-
cord-006860-a3b8hyyr	3100	14	A	A	NNP
cord-006860-a3b8hyyr	3100	15	)	)	-RRB-
cord-006860-a3b8hyyr	3100	16	,	,	,
cord-006860-a3b8hyyr	3100	17	efegatran	efegatran	NN
cord-006860-a3b8hyyr	3100	18	(	(	-LRB-
cord-006860-a3b8hyyr	3100	19	E	E	NNP
cord-006860-a3b8hyyr	3100	20	)	)	-RRB-
cord-006860-a3b8hyyr	3100	21	,	,	,
cord-006860-a3b8hyyr	3100	22	and	and	CC
cord-006860-a3b8hyyr	3100	23	PEGhiradin	PEGhiradin	NNP
cord-006860-a3b8hyyr	3100	24	(	(	-LRB-
cord-006860-a3b8hyyr	3100	25	PH	PH	NNP
cord-006860-a3b8hyyr	3100	26	)	)	-RRB-
cord-006860-a3b8hyyr	3100	27	are	be	VBP
cord-006860-a3b8hyyr	3100	28	currently	currently	RB
cord-006860-a3b8hyyr	3100	29	undergoing	undergo	VBG
cord-006860-a3b8hyyr	3100	30	extensive	extensive	JJ
cord-006860-a3b8hyyr	3100	31	clinical	clinical	JJ
cord-006860-a3b8hyyr	3100	32	trials	trial	NNS
cord-006860-a3b8hyyr	3100	33	in	in	IN
cord-006860-a3b8hyyr	3100	34	such	such	JJ
cord-006860-a3b8hyyr	3100	35	cardiovascular	cardiovascular	JJ
cord-006860-a3b8hyyr	3100	36	indications	indication	NNS
cord-006860-a3b8hyyr	3100	37	as	as	IN
cord-006860-a3b8hyyr	3100	38	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	3100	39	,	,	,
cord-006860-a3b8hyyr	3100	40	AMI	AMI	NNP
cord-006860-a3b8hyyr	3100	41	,	,	,
cord-006860-a3b8hyyr	3100	42	and	and	CC
cord-006860-a3b8hyyr	3100	43	treatment	treatment	NN
cord-006860-a3b8hyyr	3100	44	of	of	IN
cord-006860-a3b8hyyr	3100	45	unstable	unstable	JJ
cord-006860-a3b8hyyr	3100	46	angina	angina	NN
cord-006860-a3b8hyyr	3100	47	.	.	.
cord-006860-a3b8hyyr	3101	1	A	a	DT
cord-006860-a3b8hyyr	3101	2	rapid	rapid	JJ
cord-006860-a3b8hyyr	3101	3	assessment	assessment	NN
cord-006860-a3b8hyyr	3101	4	of	of	IN
cord-006860-a3b8hyyr	3101	5	the	the	DT
cord-006860-a3b8hyyr	3101	6	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3101	7	actions	action	NNS
cord-006860-a3b8hyyr	3101	8	of	of	IN
cord-006860-a3b8hyyr	3101	9	these	these	DT
cord-006860-a3b8hyyr	3101	10	agents	agent	NNS
cord-006860-a3b8hyyr	3101	11	is	be	VBZ
cord-006860-a3b8hyyr	3101	12	,	,	,
cord-006860-a3b8hyyr	3101	13	therefore	therefore	RB
cord-006860-a3b8hyyr	3101	14	,	,	,
cord-006860-a3b8hyyr	3101	15	crucial	crucial	JJ
cord-006860-a3b8hyyr	3101	16	to	to	TO
cord-006860-a3b8hyyr	3101	17	assure	assure	VB
cord-006860-a3b8hyyr	3101	18	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3101	19	efficacy	efficacy	NN
cord-006860-a3b8hyyr	3101	20	and	and	CC
cord-006860-a3b8hyyr	3101	21	safety	safety	NN
cord-006860-a3b8hyyr	3101	22	.	.	.
cord-006860-a3b8hyyr	3102	1	Currently	currently	RB
cord-006860-a3b8hyyr	3102	2	,	,	,
cord-006860-a3b8hyyr	3102	3	ACT	ACT	NNP
cord-006860-a3b8hyyr	3102	4	and	and	CC
cord-006860-a3b8hyyr	3102	5	APTT	APTT	NNP
cord-006860-a3b8hyyr	3102	6	are	be	VBP
cord-006860-a3b8hyyr	3102	7	used	use	VBN
cord-006860-a3b8hyyr	3102	8	to	to	TO
cord-006860-a3b8hyyr	3102	9	measure	measure	VB
cord-006860-a3b8hyyr	3102	10	the	the	DT
cord-006860-a3b8hyyr	3102	11	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3102	12	effect	effect	NN
cord-006860-a3b8hyyr	3102	13	of	of	IN
cord-006860-a3b8hyyr	3102	14	these	these	DT
cord-006860-a3b8hyyr	3102	15	agents	agent	NNS
cord-006860-a3b8hyyr	3102	16	.	.	.
cord-006860-a3b8hyyr	3103	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3103	2	have	have	VBP
cord-006860-a3b8hyyr	3103	3	utilized	utilize	VBN
cord-006860-a3b8hyyr	3103	4	a	a	DT
cord-006860-a3b8hyyr	3103	5	dry	dry	JJ
cord-006860-a3b8hyyr	3103	6	reagent	reagent	NN
cord-006860-a3b8hyyr	3103	7	technology	technology	NN
cord-006860-a3b8hyyr	3103	8	based	base	VBN
cord-006860-a3b8hyyr	3103	9	on	on	IN
cord-006860-a3b8hyyr	3103	10	the	the	DT
cord-006860-a3b8hyyr	3103	11	motion	motion	NN
cord-006860-a3b8hyyr	3103	12	of	of	IN
cord-006860-a3b8hyyr	3103	13	paramagnetic	paramagnetic	JJ
cord-006860-a3b8hyyr	3103	14	iron	iron	NN
cord-006860-a3b8hyyr	3103	15	oxide	oxide	NN
cord-006860-a3b8hyyr	3103	16	particles	particle	NNS
cord-006860-a3b8hyyr	3103	17	(	(	-LRB-
cord-006860-a3b8hyyr	3103	18	PLOP	plop	VB
cord-006860-a3b8hyyr	3103	19	)	)	-RRB-
cord-006860-a3b8hyyr	3103	20	to	to	TO
cord-006860-a3b8hyyr	3103	21	measure	measure	VB
cord-006860-a3b8hyyr	3103	22	the	the	DT
cord-006860-a3b8hyyr	3103	23	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3103	24	effects	effect	NNS
cord-006860-a3b8hyyr	3103	25	of	of	IN
cord-006860-a3b8hyyr	3103	26	various	various	JJ
cord-006860-a3b8hyyr	3103	27	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3103	28	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3103	29	(	(	-LRB-
cord-006860-a3b8hyyr	3103	30	CV	CV	NNP
cord-006860-a3b8hyyr	3103	31	Diagnostics	Diagnostics	NNP
cord-006860-a3b8hyyr	3103	32	,	,	,
cord-006860-a3b8hyyr	3103	33	Raleight	Raleight	NNP
cord-006860-a3b8hyyr	3103	34	,	,	,
cord-006860-a3b8hyyr	3103	35	NC	NC	NNP
cord-006860-a3b8hyyr	3103	36	)	)	-RRB-
cord-006860-a3b8hyyr	3103	37	.	.	.
cord-006860-a3b8hyyr	3104	1	The	the	DT
cord-006860-a3b8hyyr	3104	2	heparin	heparin	NN
cord-006860-a3b8hyyr	3104	3	monitoring	monitoring	NN
cord-006860-a3b8hyyr	3104	4	card	card	NN
cord-006860-a3b8hyyr	3104	5	has	have	VBZ
cord-006860-a3b8hyyr	3104	6	been	be	VBN
cord-006860-a3b8hyyr	3104	7	modified	modify	VBN
cord-006860-a3b8hyyr	3104	8	to	to	TO
cord-006860-a3b8hyyr	3104	9	measure	measure	VB
cord-006860-a3b8hyyr	3104	10	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3104	11	agents	agent	NNS
cord-006860-a3b8hyyr	3104	12	in	in	IN
cord-006860-a3b8hyyr	3104	13	various	various	JJ
cord-006860-a3b8hyyr	3104	14	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3104	15	ranges	range	NNS
cord-006860-a3b8hyyr	3104	16	for	for	IN
cord-006860-a3b8hyyr	3104	17	(	(	-LRB-
cord-006860-a3b8hyyr	3104	18	A)0	a)0	NN
cord-006860-a3b8hyyr	3104	19	(	(	-LRB-
cord-006860-a3b8hyyr	3104	20	E	E	NNP
cord-006860-a3b8hyyr	3104	21	)	)	-RRB-
cord-006860-a3b8hyyr	3104	22	,	,	,
cord-006860-a3b8hyyr	3104	23	(	(	-LRB-
cord-006860-a3b8hyyr	3104	24	RH	RH	NNP
cord-006860-a3b8hyyr	3104	25	)	)	-RRB-
cord-006860-a3b8hyyr	3104	26	,	,	,
cord-006860-a3b8hyyr	3104	27	and	and	CC
cord-006860-a3b8hyyr	3104	28	(	(	-LRB-
cord-006860-a3b8hyyr	3104	29	PH	PH	NNP
cord-006860-a3b8hyyr	3104	30	)	)	-RRB-
cord-006860-a3b8hyyr	3104	31	.	.	.
cord-006860-a3b8hyyr	3105	1	Blood	blood	NN
cord-006860-a3b8hyyr	3105	2	samples	sample	NNS
cord-006860-a3b8hyyr	3105	3	drawn	draw	VBN
cord-006860-a3b8hyyr	3105	4	from	from	IN
cord-006860-a3b8hyyr	3105	5	patients	patient	NNS
cord-006860-a3b8hyyr	3105	6	treated	treat	VBN
cord-006860-a3b8hyyr	3105	7	with	with	IN
cord-006860-a3b8hyyr	3105	8	(	(	-LRB-
cord-006860-a3b8hyyr	3105	9	A	a	NN
cord-006860-a3b8hyyr	3105	10	)	)	-RRB-
cord-006860-a3b8hyyr	3105	11	and	and	CC
cord-006860-a3b8hyyr	3105	12	(	(	-LRB-
cord-006860-a3b8hyyr	3105	13	RH	RH	NNP
cord-006860-a3b8hyyr	3105	14	)	)	-RRB-
cord-006860-a3b8hyyr	3105	15	have	have	VBP
cord-006860-a3b8hyyr	3105	16	been	be	VBN
cord-006860-a3b8hyyr	3105	17	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	3105	18	and	and	CC
cord-006860-a3b8hyyr	3105	19	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3105	20	of	of	IN
cord-006860-a3b8hyyr	3105	21	these	these	DT
cord-006860-a3b8hyyr	3105	22	agents	agent	NNS
cord-006860-a3b8hyyr	3105	23	have	have	VBP
cord-006860-a3b8hyyr	3105	24	been	be	VBN
cord-006860-a3b8hyyr	3105	25	calculated	calculate	VBN
cord-006860-a3b8hyyr	3105	26	using	use	VBG
cord-006860-a3b8hyyr	3105	27	an	an	DT
cord-006860-a3b8hyyr	3105	28	external	external	JJ
cord-006860-a3b8hyyr	3105	29	calibration	calibration	NN
cord-006860-a3b8hyyr	3105	30	curve	curve	NN
cord-006860-a3b8hyyr	3105	31	.	.	.
cord-006860-a3b8hyyr	3106	1	In	in	IN
cord-006860-a3b8hyyr	3106	2	the	the	DT
cord-006860-a3b8hyyr	3106	3	in	in	FW
cord-006860-a3b8hyyr	3106	4	vitro	vitro	FW
cord-006860-a3b8hyyr	3106	5	setting	setting	NN
cord-006860-a3b8hyyr	3106	6	,	,	,
cord-006860-a3b8hyyr	3106	7	citrated	citrate	VBD
cord-006860-a3b8hyyr	3106	8	whole	whole	JJ
cord-006860-a3b8hyyr	3106	9	blood	blood	NN
cord-006860-a3b8hyyr	3106	10	or	or	CC
cord-006860-a3b8hyyr	3106	11	citrated	citrate	VBD
cord-006860-a3b8hyyr	3106	12	frozen	frozen	JJ
cord-006860-a3b8hyyr	3106	13	plasma	plasma	NN
cord-006860-a3b8hyyr	3106	14	can	can	MD
cord-006860-a3b8hyyr	3106	15	be	be	VB
cord-006860-a3b8hyyr	3106	16	used	use	VBN
cord-006860-a3b8hyyr	3106	17	to	to	TO
cord-006860-a3b8hyyr	3106	18	evaluate	evaluate	VB
cord-006860-a3b8hyyr	3106	19	the	the	DT
cord-006860-a3b8hyyr	3106	20	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3106	21	effects	effect	NNS
cord-006860-a3b8hyyr	3106	22	of	of	IN
cord-006860-a3b8hyyr	3106	23	these	these	DT
cord-006860-a3b8hyyr	3106	24	agents	agent	NNS
cord-006860-a3b8hyyr	3106	25	.	.	.
cord-006860-a3b8hyyr	3107	1	The	the	DT
cord-006860-a3b8hyyr	3107	2	results	result	NNS
cord-006860-a3b8hyyr	3107	3	obtained	obtain	VBN
cord-006860-a3b8hyyr	3107	4	are	be	VBP
cord-006860-a3b8hyyr	3107	5	comparable	comparable	JJ
cord-006860-a3b8hyyr	3107	6	to	to	IN
cord-006860-a3b8hyyr	3107	7	the	the	DT
cord-006860-a3b8hyyr	3107	8	ACT	ACT	NNP
cord-006860-a3b8hyyr	3107	9	which	which	WDT
cord-006860-a3b8hyyr	3107	10	is	be	VBZ
cord-006860-a3b8hyyr	3107	11	conventionally	conventionally	RB
cord-006860-a3b8hyyr	3107	12	used	use	VBN
cord-006860-a3b8hyyr	3107	13	for	for	IN
cord-006860-a3b8hyyr	3107	14	the	the	DT
cord-006860-a3b8hyyr	3107	15	monitoring	monitoring	NN
cord-006860-a3b8hyyr	3107	16	of	of	IN
cord-006860-a3b8hyyr	3107	17	these	these	DT
cord-006860-a3b8hyyr	3107	18	agents	agent	NNS
cord-006860-a3b8hyyr	3107	19	.	.	.
cord-006860-a3b8hyyr	3108	1	Both	both	DT
cord-006860-a3b8hyyr	3108	2	(	(	-LRB-
cord-006860-a3b8hyyr	3108	3	RH	RH	NNP
cord-006860-a3b8hyyr	3108	4	)	)	-RRB-
cord-006860-a3b8hyyr	3108	5	and	and	CC
cord-006860-a3b8hyyr	3108	6	(	(	-LRB-
cord-006860-a3b8hyyr	3108	7	 	 	_SP
cord-006860-a3b8hyyr	3108	8	period	period	NN
cord-006860-a3b8hyyr	3108	9	.	.	.
cord-006860-a3b8hyyr	3109	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3109	2	would	would	MD
cord-006860-a3b8hyyr	3109	3	like	like	VB
cord-006860-a3b8hyyr	3109	4	to	to	TO
cord-006860-a3b8hyyr	3109	5	present	present	VB
cord-006860-a3b8hyyr	3109	6	a	a	DT
cord-006860-a3b8hyyr	3109	7	case	case	NN
cord-006860-a3b8hyyr	3109	8	of	of	IN
cord-006860-a3b8hyyr	3109	9	heparin	heparin	NN
cord-006860-a3b8hyyr	3109	10	-	-	HYPH
cord-006860-a3b8hyyr	3109	11	induced	induce	VBN
cord-006860-a3b8hyyr	3109	12	-	-	HYPH
cord-006860-a3b8hyyr	3109	13	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	3109	14	(	(	-LRB-
cord-006860-a3b8hyyr	3109	15	HIT	hit	VB
cord-006860-a3b8hyyr	3109	16	)	)	-RRB-
cord-006860-a3b8hyyr	3109	17	in	in	IN
cord-006860-a3b8hyyr	3109	18	a	a	DT
cord-006860-a3b8hyyr	3109	19	47	47	CD
cord-006860-a3b8hyyr	3109	20	years	year	NNS
cord-006860-a3b8hyyr	3109	21	old	old	JJ
cord-006860-a3b8hyyr	3109	22	woman	woman	NN
cord-006860-a3b8hyyr	3109	23	who	who	WP
cord-006860-a3b8hyyr	3109	24	underwend	underwend	VBP
cord-006860-a3b8hyyr	3109	25	open	open	JJ
cord-006860-a3b8hyyr	3109	26	heart	heart	NN
cord-006860-a3b8hyyr	3109	27	surgery	surgery	NN
cord-006860-a3b8hyyr	3109	28	.	.	.
cord-006860-a3b8hyyr	3110	1	She	-PRON-	PRP
cord-006860-a3b8hyyr	3110	2	suffered	suffer	VBD
cord-006860-a3b8hyyr	3110	3	from	from	IN
cord-006860-a3b8hyyr	3110	4	a	a	DT
cord-006860-a3b8hyyr	3110	5	combined	combine	VBN
cord-006860-a3b8hyyr	3110	6	aortic	aortic	JJ
cord-006860-a3b8hyyr	3110	7	valve	valve	NN
cord-006860-a3b8hyyr	3110	8	disease	disease	NN
cord-006860-a3b8hyyr	3110	9	and	and	CC
cord-006860-a3b8hyyr	3110	10	leading	leading	JJ
cord-006860-a3b8hyyr	3110	11	stenosis	stenosis	NN
cord-006860-a3b8hyyr	3110	12	.	.	.
cord-006860-a3b8hyyr	3111	1	Laboratory	laboratory	NN
cord-006860-a3b8hyyr	3111	2	analysis	analysis	NN
cord-006860-a3b8hyyr	3111	3	showed	show	VBD
cord-006860-a3b8hyyr	3111	4	constant	constant	JJ
cord-006860-a3b8hyyr	3111	5	low	low	JJ
cord-006860-a3b8hyyr	3111	6	platelet	platelet	NN
cord-006860-a3b8hyyr	3111	7	counts	count	NNS
cord-006860-a3b8hyyr	3111	8	(	(	-LRB-
cord-006860-a3b8hyyr	3111	9	50	50	CD
cord-006860-a3b8hyyr	3111	10	/	/	SYM
cord-006860-a3b8hyyr	3111	11	nl	nl	NNP
cord-006860-a3b8hyyr	3111	12	)	)	-RRB-
cord-006860-a3b8hyyr	3111	13	without	without	IN
cord-006860-a3b8hyyr	3111	14	heparin	heparin	NN
cord-006860-a3b8hyyr	3111	15	application	application	NN
cord-006860-a3b8hyyr	3111	16	,	,	,
cord-006860-a3b8hyyr	3111	17	so	so	IN
cord-006860-a3b8hyyr	3111	18	that	that	IN
cord-006860-a3b8hyyr	3111	19	an	an	DT
cord-006860-a3b8hyyr	3111	20	idiopathic	idiopathic	JJ
cord-006860-a3b8hyyr	3111	21	thrombocytopenlc	thrombocytopenlc	NN
cord-006860-a3b8hyyr	3111	22	purpura	purpura	NN
cord-006860-a3b8hyyr	3111	23	was	be	VBD
cord-006860-a3b8hyyr	3111	24	suspected	suspect	VBN
cord-006860-a3b8hyyr	3111	25	.	.	.
cord-006860-a3b8hyyr	3112	1	But	but	CC
cord-006860-a3b8hyyr	3112	2	platelets	platelet	NNS
cord-006860-a3b8hyyr	3112	3	also	also	RB
cord-006860-a3b8hyyr	3112	4	decreased	decrease	VBD
cord-006860-a3b8hyyr	3112	5	after	after	IN
cord-006860-a3b8hyyr	3112	6	heparin	heparin	NN
cord-006860-a3b8hyyr	3112	7	application	application	NN
cord-006860-a3b8hyyr	3112	8	.	.	.
cord-006860-a3b8hyyr	3113	1	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	3113	2	-	-	HYPH
cord-006860-a3b8hyyr	3113	3	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3113	4	were	be	VBD
cord-006860-a3b8hyyr	3113	5	found	find	VBN
cord-006860-a3b8hyyr	3113	6	in	in	IN
cord-006860-a3b8hyyr	3113	7	the	the	DT
cord-006860-a3b8hyyr	3113	8	heparin	heparin	NN
cord-006860-a3b8hyyr	3113	9	induced	induce	VBN
cord-006860-a3b8hyyr	3113	10	platelet	platelet	NN
cord-006860-a3b8hyyr	3113	11	activation	activation	NN
cord-006860-a3b8hyyr	3113	12	assay	assay	NN
cord-006860-a3b8hyyr	3113	13	(	(	-LRB-
cord-006860-a3b8hyyr	3113	14	HIPAA	HIPAA	NNP
cord-006860-a3b8hyyr	3113	15	)	)	-RRB-
cord-006860-a3b8hyyr	3113	16	.	.	.
cord-006860-a3b8hyyr	3114	1	Treatment	treatment	NN
cord-006860-a3b8hyyr	3114	2	with	with	IN
cord-006860-a3b8hyyr	3114	3	corticosteroids	corticosteroid	NNS
cord-006860-a3b8hyyr	3114	4	and	and	CC
cord-006860-a3b8hyyr	3114	5	immunoglobulines	immunoglobuline	NNS
cord-006860-a3b8hyyr	3114	6	,	,	,
cord-006860-a3b8hyyr	3114	7	respectively	respectively	RB
cord-006860-a3b8hyyr	3114	8	,	,	,
cord-006860-a3b8hyyr	3114	9	showed	show	VBD
cord-006860-a3b8hyyr	3114	10	no	no	DT
cord-006860-a3b8hyyr	3114	11	improvement	improvement	NN
cord-006860-a3b8hyyr	3114	12	but	but	CC
cord-006860-a3b8hyyr	3114	13	the	the	DT
cord-006860-a3b8hyyr	3114	14	patient	patient	NN
cord-006860-a3b8hyyr	3114	15	unfortunately	unfortunately	RB
cord-006860-a3b8hyyr	3114	16	developed	develop	VBD
cord-006860-a3b8hyyr	3114	17	a	a	DT
cord-006860-a3b8hyyr	3114	18	pneumonia	pneumonia	NN
cord-006860-a3b8hyyr	3114	19	with	with	IN
cord-006860-a3b8hyyr	3114	20	legionetla	legionetla	NNP
cord-006860-a3b8hyyr	3114	21	pneumophila	pneumophila	NN
cord-006860-a3b8hyyr	3114	22	.	.	.
cord-006860-a3b8hyyr	3115	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	3115	2	,	,	,
cord-006860-a3b8hyyr	3115	3	the	the	DT
cord-006860-a3b8hyyr	3115	4	only	only	JJ
cord-006860-a3b8hyyr	3115	5	suitable	suitable	JJ
cord-006860-a3b8hyyr	3115	6	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3115	7	for	for	IN
cord-006860-a3b8hyyr	3115	8	the	the	DT
cord-006860-a3b8hyyr	3115	9	necessary	necessary	JJ
cord-006860-a3b8hyyr	3115	10	aortic	aortic	JJ
cord-006860-a3b8hyyr	3115	11	valve	valve	NN
cord-006860-a3b8hyyr	3115	12	replacement	replacement	NN
cord-006860-a3b8hyyr	3115	13	was	be	VBD
cord-006860-a3b8hyyr	3115	14	Hirudin	hirudin	NN
cord-006860-a3b8hyyr	3115	15	:	:	:
cord-006860-a3b8hyyr	3116	1	A	a	DT
cord-006860-a3b8hyyr	3116	2	bolus	bolus	NN
cord-006860-a3b8hyyr	3116	3	injection	injection	NN
cord-006860-a3b8hyyr	3116	4	of	of	IN
cord-006860-a3b8hyyr	3116	5	r	r	NN
cord-006860-a3b8hyyr	3116	6	-	-	:
cord-006860-a3b8hyyr	3116	7	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3116	8	of	of	IN
cord-006860-a3b8hyyr	3116	9	0,75	0,75	NNP
cord-006860-a3b8hyyr	3116	10	mg	mg	NNP
cord-006860-a3b8hyyr	3116	11	/	/	SYM
cord-006860-a3b8hyyr	3116	12	kg	kg	NNP
cord-006860-a3b8hyyr	3116	13	b.w	b.w	NNP
cord-006860-a3b8hyyr	3116	14	.	.	NNP
cord-006860-a3b8hyyr	3116	15	was	be	VBD
cord-006860-a3b8hyyr	3116	16	administered	administer	VBN
cord-006860-a3b8hyyr	3116	17	10	10	CD
cord-006860-a3b8hyyr	3116	18	min	min	NN
cord-006860-a3b8hyyr	3116	19	.	.	.
cord-006860-a3b8hyyr	3117	1	bevore	bevore	RB
cord-006860-a3b8hyyr	3117	2	start	start	VB
cord-006860-a3b8hyyr	3117	3	of	of	IN
cord-006860-a3b8hyyr	3117	4	the	the	DT
cord-006860-a3b8hyyr	3117	5	extracorporal	extracorporal	JJ
cord-006860-a3b8hyyr	3117	6	circulation	circulation	NN
cord-006860-a3b8hyyr	3117	7	(	(	-LRB-
cord-006860-a3b8hyyr	3117	8	ECC	ECC	NNP
cord-006860-a3b8hyyr	3117	9	)	)	-RRB-
cord-006860-a3b8hyyr	3117	10	,	,	,
cord-006860-a3b8hyyr	3117	11	the	the	DT
cord-006860-a3b8hyyr	3117	12	heart	heart	NN
cord-006860-a3b8hyyr	3117	13	-	-	HYPH
cord-006860-a3b8hyyr	3117	14	lung	lung	NN
cord-006860-a3b8hyyr	3117	15	machine	machine	NN
cord-006860-a3b8hyyr	3117	16	(	(	-LRB-
cord-006860-a3b8hyyr	3117	17	HLM	HLM	NNP
cord-006860-a3b8hyyr	3117	18	)	)	-RRB-
cord-006860-a3b8hyyr	3117	19	was	be	VBD
cord-006860-a3b8hyyr	3117	20	primed	prime	VBN
cord-006860-a3b8hyyr	3117	21	with	with	IN
cord-006860-a3b8hyyr	3117	22	6	6	CD
cord-006860-a3b8hyyr	3117	23	mg	mg	NN
cord-006860-a3b8hyyr	3117	24	r	r	NN
cord-006860-a3b8hyyr	3117	25	-	-	:
cord-006860-a3b8hyyr	3117	26	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3117	27	and	and	CC
cord-006860-a3b8hyyr	3117	28	another	another	DT
cord-006860-a3b8hyyr	3117	29	bolus	bolus	NN
cord-006860-a3b8hyyr	3117	30	of	of	IN
cord-006860-a3b8hyyr	3117	31	5	5	CD
cord-006860-a3b8hyyr	3117	32	mg	mg	NN
cord-006860-a3b8hyyr	3117	33	of	of	IN
cord-006860-a3b8hyyr	3117	34	r	r	NNP
cord-006860-a3b8hyyr	3117	35	-	-	:
cord-006860-a3b8hyyr	3117	36	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3117	37	was	be	VBD
cord-006860-a3b8hyyr	3117	38	administered	administer	VBN
cord-006860-a3b8hyyr	3117	39	.	.	.
cord-006860-a3b8hyyr	3118	1	Additionally	additionally	RB
cord-006860-a3b8hyyr	3118	2	10	10	CD
cord-006860-a3b8hyyr	3118	3	mg	mg	NN
cord-006860-a3b8hyyr	3118	4	of	of	IN
cord-006860-a3b8hyyr	3118	5	r	r	NNP
cord-006860-a3b8hyyr	3118	6	-	-	:
cord-006860-a3b8hyyr	3118	7	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3118	8	was	be	VBD
cord-006860-a3b8hyyr	3118	9	applicated	applicate	VBN
cord-006860-a3b8hyyr	3118	10	to	to	IN
cord-006860-a3b8hyyr	3118	11	the	the	DT
cord-006860-a3b8hyyr	3118	12	cell	cell	NN
cord-006860-a3b8hyyr	3118	13	-	-	HYPH
cord-006860-a3b8hyyr	3118	14	saver	saver	NN
cord-006860-a3b8hyyr	3118	15	-	-	HYPH
cord-006860-a3b8hyyr	3118	16	reservoir	reservoir	NN
cord-006860-a3b8hyyr	3118	17	.	.	.
cord-006860-a3b8hyyr	3119	1	During	during	IN
cord-006860-a3b8hyyr	3119	2	the	the	DT
cord-006860-a3b8hyyr	3119	3	period	period	NN
cord-006860-a3b8hyyr	3119	4	of	of	IN
cord-006860-a3b8hyyr	3119	5	ECC	ECC	NNP
cord-006860-a3b8hyyr	3119	6	Ecarin	Ecarin	NNP
cord-006860-a3b8hyyr	3119	7	clotting	clotting	NN
cord-006860-a3b8hyyr	3119	8	time	time	NN
cord-006860-a3b8hyyr	3119	9	and	and	CC
cord-006860-a3b8hyyr	3119	10	aPTT	aPTT	NNS
cord-006860-a3b8hyyr	3119	11	values	value	NNS
cord-006860-a3b8hyyr	3119	12	were	be	VBD
cord-006860-a3b8hyyr	3119	13	taken	take	VBN
cord-006860-a3b8hyyr	3119	14	every	every	DT
cord-006860-a3b8hyyr	3119	15	ten	ten	CD
cord-006860-a3b8hyyr	3119	16	minutes	minute	NNS
cord-006860-a3b8hyyr	3119	17	for	for	IN
cord-006860-a3b8hyyr	3119	18	monitoring	monitor	VBG
cord-006860-a3b8hyyr	3119	19	r	r	NN
cord-006860-a3b8hyyr	3119	20	-	-	HYPH
cord-006860-a3b8hyyr	3119	21	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3119	22	concentration	concentration	NN
cord-006860-a3b8hyyr	3119	23	.	.	.
cord-006860-a3b8hyyr	3120	1	The	the	DT
cord-006860-a3b8hyyr	3120	2	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	3120	3	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3120	4	was	be	VBD
cord-006860-a3b8hyyr	3120	5	performed	perform	VBN
cord-006860-a3b8hyyr	3120	6	with	with	IN
cord-006860-a3b8hyyr	3120	7	a	a	DT
cord-006860-a3b8hyyr	3120	8	constant	constant	JJ
cord-006860-a3b8hyyr	3120	9	infusion	infusion	NN
cord-006860-a3b8hyyr	3120	10	of	of	IN
cord-006860-a3b8hyyr	3120	11	r	r	NN
cord-006860-a3b8hyyr	3120	12	-	-	:
cord-006860-a3b8hyyr	3120	13	Hirudin	hirudin	NN
cord-006860-a3b8hyyr	3120	14	starting	start	VBG
cord-006860-a3b8hyyr	3120	15	eight	eight	CD
cord-006860-a3b8hyyr	3120	16	hours	hour	NNS
cord-006860-a3b8hyyr	3120	17	after	after	IN
cord-006860-a3b8hyyr	3120	18	the	the	DT
cord-006860-a3b8hyyr	3120	19	end	end	NN
cord-006860-a3b8hyyr	3120	20	of	of	IN
cord-006860-a3b8hyyr	3120	21	ECC	ECC	NNP
cord-006860-a3b8hyyr	3120	22	and	and	CC
cord-006860-a3b8hyyr	3120	23	monitored	monitor	VBN
cord-006860-a3b8hyyr	3120	24	by	by	IN
cord-006860-a3b8hyyr	3120	25	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	3120	26	.	.	.
cord-006860-a3b8hyyr	3121	1	Due	due	IN
cord-006860-a3b8hyyr	3121	2	to	to	IN
cord-006860-a3b8hyyr	3121	3	mechanical	mechanical	JJ
cord-006860-a3b8hyyr	3121	4	aortic	aortic	JJ
cord-006860-a3b8hyyr	3121	5	valve	valve	NN
cord-006860-a3b8hyyr	3121	6	the	the	DT
cord-006860-a3b8hyyr	3121	7	further	further	JJ
cord-006860-a3b8hyyr	3121	8	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3121	9	was	be	VBD
cord-006860-a3b8hyyr	3121	10	performed	perform	VBN
cord-006860-a3b8hyyr	3121	11	with	with	IN
cord-006860-a3b8hyyr	3121	12	phenprocoumon	phenprocoumon	NNP
cord-006860-a3b8hyyr	3121	13	,	,	,
cord-006860-a3b8hyyr	3121	14	starting	start	VBG
cord-006860-a3b8hyyr	3121	15	3	3	CD
cord-006860-a3b8hyyr	3121	16	days	day	NNS
cord-006860-a3b8hyyr	3121	17	postop	postop	NN
cord-006860-a3b8hyyr	3121	18	.	.	.
cord-006860-a3b8hyyr	3122	1	The	the	DT
cord-006860-a3b8hyyr	3122	2	therapy	therapy	NN
cord-006860-a3b8hyyr	3122	3	with	with	IN
cord-006860-a3b8hyyr	3122	4	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3122	5	showed	show	VBD
cord-006860-a3b8hyyr	3122	6	no	no	DT
cord-006860-a3b8hyyr	3122	7	side	side	NN
cord-006860-a3b8hyyr	3122	8	-	-	HYPH
cord-006860-a3b8hyyr	3122	9	effects	effect	NNS
cord-006860-a3b8hyyr	3122	10	.	.	.
cord-006860-a3b8hyyr	3123	1	Hirudin	hirudin	RB
cord-006860-a3b8hyyr	3123	2	,	,	,
cord-006860-a3b8hyyr	3123	3	threrefore	threrefore	NNP
cord-006860-a3b8hyyr	3123	4	seems	seem	VBZ
cord-006860-a3b8hyyr	3123	5	to	to	TO
cord-006860-a3b8hyyr	3123	6	be	be	VB
cord-006860-a3b8hyyr	3123	7	a	a	DT
cord-006860-a3b8hyyr	3123	8	suitable	suitable	JJ
cord-006860-a3b8hyyr	3123	9	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3123	10	in	in	IN
cord-006860-a3b8hyyr	3123	11	patients	patient	NNS
cord-006860-a3b8hyyr	3123	12	with	with	IN
cord-006860-a3b8hyyr	3123	13	high	high	JJ
cord-006860-a3b8hyyr	3123	14	risk	risk	NN
cord-006860-a3b8hyyr	3123	15	for	for	IN
cord-006860-a3b8hyyr	3123	16	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3123	17	complications	complication	NNS
cord-006860-a3b8hyyr	3123	18	like	like	IN
cord-006860-a3b8hyyr	3123	19	this	this	DT
cord-006860-a3b8hyyr	3123	20	.	.	.
cord-006860-a3b8hyyr	3124	1	Doses	dose	NNS
cord-006860-a3b8hyyr	3124	2	fi	fi	NNP
cord-006860-a3b8hyyr	3124	3	:	:	:
cord-006860-a3b8hyyr	3125	1	om	om	NNP
cord-006860-a3b8hyyr	3125	2	2	2	CD
cord-006860-a3b8hyyr	3125	3	-	-	SYM
cord-006860-a3b8hyyr	3125	4	30	30	CD
cord-006860-a3b8hyyr	3125	5	mg	mg	NNP
cord-006860-a3b8hyyr	3125	6	/	/	SYM
cord-006860-a3b8hyyr	3125	7	kg	kg	NNS
cord-006860-a3b8hyyr	3125	8	gave	give	VBD
cord-006860-a3b8hyyr	3125	9	similar	similar	JJ
cord-006860-a3b8hyyr	3125	10	post	post	JJ
cord-006860-a3b8hyyr	3125	11	-	-	JJ
cord-006860-a3b8hyyr	3125	12	op	op	JJ
cord-006860-a3b8hyyr	3125	13	blood	blood	NN
cord-006860-a3b8hyyr	3125	14	loss	loss	NN
cord-006860-a3b8hyyr	3125	15	measurements	measurement	NNS
cord-006860-a3b8hyyr	3125	16	without	without	IN
cord-006860-a3b8hyyr	3125	17	s	s	NNP
cord-006860-a3b8hyyr	3125	18	dnseresponse	dnseresponse	NN
cord-006860-a3b8hyyr	3125	19	(	(	-LRB-
cord-006860-a3b8hyyr	3125	20	4	4	CD
cord-006860-a3b8hyyr	3125	21	-	-	SYM
cord-006860-a3b8hyyr	3125	22	15	15	CD
cord-006860-a3b8hyyr	3125	23	oc	oc	NN
cord-006860-a3b8hyyr	3125	24	/	/	SYM
cord-006860-a3b8hyyr	3125	25	kg	kg	NN
cord-006860-a3b8hyyr	3125	26	)	)	-RRB-
cord-006860-a3b8hyyr	3125	27	(	(	-LRB-
cord-006860-a3b8hyyr	3125	28	less	less	RBR
cord-006860-a3b8hyyr	3125	29	blood	blood	NN
cord-006860-a3b8hyyr	3125	30	oozing	oozing	NN
cord-006860-a3b8hyyr	3125	31	than	than	IN
cord-006860-a3b8hyyr	3125	32	a	a	DT
cord-006860-a3b8hyyr	3125	33	historical	historical	JJ
cord-006860-a3b8hyyr	3125	34	heparin	heparin	NN
cord-006860-a3b8hyyr	3125	35	control	control	NN
cord-006860-a3b8hyyr	3125	36	but	but	CC
cord-006860-a3b8hyyr	3125	37	equivalent	equivalent	JJ
cord-006860-a3b8hyyr	3125	38	post	post	JJ
cord-006860-a3b8hyyr	3125	39	-	-	JJ
cord-006860-a3b8hyyr	3125	40	op	op	JJ
cord-006860-a3b8hyyr	3125	41	blood	blood	NN
cord-006860-a3b8hyyr	3125	42	loss	loss	NN
cord-006860-a3b8hyyr	3125	43	;	;	:
cord-006860-a3b8hyyr	3125	44	10	10	CD
cord-006860-a3b8hyyr	3125	45	q-3	q-3	NNP
cord-006860-a3b8hyyr	3125	46	ec	ec	NNP
cord-006860-a3b8hyyr	3125	47	/	/	SYM
cord-006860-a3b8hyyr	3125	48	kg	kg	NNP
cord-006860-a3b8hyyr	3125	49	)	)	-RRB-
cord-006860-a3b8hyyr	3125	50	.	.	.
cord-006860-a3b8hyyr	3126	1	Doses	dose	NNS
cord-006860-a3b8hyyr	3126	2	>	>	XX
cord-006860-a3b8hyyr	3127	1	30	30	CD
cord-006860-a3b8hyyr	3127	2	mg	mg	NNP
cord-006860-a3b8hyyr	3127	3	/	/	SYM
cord-006860-a3b8hyyr	3127	4	kg	kg	NNS
cord-006860-a3b8hyyr	3127	5	showed	show	VBD
cord-006860-a3b8hyyr	3127	6	more	more	JJR
cord-006860-a3b8hyyr	3127	7	intra	intra	JJ
cord-006860-a3b8hyyr	3127	8	-	-	JJ
cord-006860-a3b8hyyr	3127	9	op	op	JJ
cord-006860-a3b8hyyr	3127	10	blood	blood	NN
cord-006860-a3b8hyyr	3127	11	loss	loss	NN
cord-006860-a3b8hyyr	3127	12	than	than	IN
cord-006860-a3b8hyyr	3127	13	the	the	DT
cord-006860-a3b8hyyr	3127	14	lowe~	lowe~	NNP
cord-006860-a3b8hyyr	3127	15	doses	dose	NNS
cord-006860-a3b8hyyr	3127	16	,	,	,
cord-006860-a3b8hyyr	3127	17	but	but	CC
cord-006860-a3b8hyyr	3127	18	equal	equal	JJ
cord-006860-a3b8hyyr	3127	19	post-.op	post-.op	NNP
cord-006860-a3b8hyyr	3127	20	blood	blood	NN
cord-006860-a3b8hyyr	3127	21	loss	loss	NN
cord-006860-a3b8hyyr	3127	22	.	.	.
cord-006860-a3b8hyyr	3128	1	The	the	DT
cord-006860-a3b8hyyr	3128	2	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3128	3	time	time	NN
cord-006860-a3b8hyyr	3128	4	test	test	NN
cord-006860-a3b8hyyr	3128	5	was	be	VBD
cord-006860-a3b8hyyr	3128	6	less	less	RBR
cord-006860-a3b8hyyr	3128	7	elevated	elevated	JJ
cord-006860-a3b8hyyr	3128	8	than	than	IN
cord-006860-a3b8hyyr	3128	9	for	for	IN
cord-006860-a3b8hyyr	3128	10	heparin	heparin	NN
cord-006860-a3b8hyyr	3128	11	.	.	.
cord-006860-a3b8hyyr	3129	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	3129	2	counts	count	NNS
cord-006860-a3b8hyyr	3129	3	and	and	CC
cord-006860-a3b8hyyr	3129	4	hematoerit	hematoerit	NNP
cord-006860-a3b8hyyr	3129	5	did	do	VBD
cord-006860-a3b8hyyr	3129	6	not	not	RB
cord-006860-a3b8hyyr	3129	7	vary	vary	VB
cord-006860-a3b8hyyr	3129	8	except	except	IN
cord-006860-a3b8hyyr	3129	9	for	for	IN
cord-006860-a3b8hyyr	3129	10	hemodihition	hemodihition	NN
cord-006860-a3b8hyyr	3129	11	on	on	IN
cord-006860-a3b8hyyr	3129	12	pump	pump	NN
cord-006860-a3b8hyyr	3129	13	.	.	.
cord-006860-a3b8hyyr	3130	1	Liver	liver	NN
cord-006860-a3b8hyyr	3130	2	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	3130	3	did	do	VBD
cord-006860-a3b8hyyr	3130	4	not	not	RB
cord-006860-a3b8hyyr	3130	5	vary	vary	VB
cord-006860-a3b8hyyr	3130	6	significantly	significantly	RB
cord-006860-a3b8hyyr	3130	7	pre	pre	VB
cord-006860-a3b8hyyr	3130	8	-	-	NN
cord-006860-a3b8hyyr	3130	9	op	op	NN
cord-006860-a3b8hyyr	3130	10	to	to	TO
cord-006860-a3b8hyyr	3130	11	post	post	VB
cord-006860-a3b8hyyr	3130	12	.	.	.
cord-006860-a3b8hyyr	3131	1	ACT	ACT	NNP
cord-006860-a3b8hyyr	3131	2	values	value	NNS
cord-006860-a3b8hyyr	3131	3	showed	show	VBD
cord-006860-a3b8hyyr	3131	4	ARG	ARG	NNP
cord-006860-a3b8hyyr	3131	5	was	be	VBD
cord-006860-a3b8hyyr	3131	6	eliminated	eliminate	VBN
cord-006860-a3b8hyyr	3131	7	(	(	-LRB-
cord-006860-a3b8hyyr	3131	8	dose	dose	NN
cord-006860-a3b8hyyr	3131	9	-	-	HYPH
cord-006860-a3b8hyyr	3131	10	dependently	dependently	RB
cord-006860-a3b8hyyr	3131	11	)	)	-RRB-
cord-006860-a3b8hyyr	3131	12	by	by	IN
cord-006860-a3b8hyyr	3131	13	1	1	CD
cord-006860-a3b8hyyr	3131	14	hour	hour	NN
cord-006860-a3b8hyyr	3131	15	post	post	NN
cord-006860-a3b8hyyr	3131	16	-	-	NN
cord-006860-a3b8hyyr	3131	17	op	op	NN
cord-006860-a3b8hyyr	3131	18	.	.	.
cord-006860-a3b8hyyr	3132	1	Dogs	dog	NNS
cord-006860-a3b8hyyr	3132	2	were	be	VBD
cord-006860-a3b8hyyr	3132	3	hemodymamieally	hemodymamieally	RB
cord-006860-a3b8hyyr	3132	4	stable	stable	JJ
cord-006860-a3b8hyyr	3132	5	during	during	IN
cord-006860-a3b8hyyr	3132	6	the	the	DT
cord-006860-a3b8hyyr	3132	7	peri	peri	JJ
cord-006860-a3b8hyyr	3132	8	-	-	HYPH
cord-006860-a3b8hyyr	3132	9	operative	operative	JJ
cord-006860-a3b8hyyr	3132	10	period	period	NN
cord-006860-a3b8hyyr	3132	11	,	,	,
cord-006860-a3b8hyyr	3132	12	and	and	CC
cord-006860-a3b8hyyr	3132	13	overall	overall	RB
cord-006860-a3b8hyyr	3132	14	gave	give	VBD
cord-006860-a3b8hyyr	3132	15	predictable	predictable	JJ
cord-006860-a3b8hyyr	3132	16	responses	response	NNS
cord-006860-a3b8hyyr	3132	17	to	to	IN
cord-006860-a3b8hyyr	3132	18	ARG	ARG	NNP
cord-006860-a3b8hyyr	3132	19	(	(	-LRB-
cord-006860-a3b8hyyr	3132	20	as	as	IN
cord-006860-a3b8hyyr	3132	21	opposed	oppose	VBN
cord-006860-a3b8hyyr	3132	22	to	to	IN
cord-006860-a3b8hyyr	3132	23	variable	variable	JJ
cord-006860-a3b8hyyr	3132	24	responses	response	NNS
cord-006860-a3b8hyyr	3132	25	to	to	IN
cord-006860-a3b8hyyr	3132	26	heparin	heparin	NN
cord-006860-a3b8hyyr	3132	27	)	)	-RRB-
cord-006860-a3b8hyyr	3132	28	.	.	.
cord-006860-a3b8hyyr	3133	1	In	in	IN
cord-006860-a3b8hyyr	3133	2	a	a	DT
cord-006860-a3b8hyyr	3133	3	substudy	substudy	NN
cord-006860-a3b8hyyr	3133	4	it	-PRON-	PRP
cord-006860-a3b8hyyr	3133	5	was	be	VBD
cord-006860-a3b8hyyr	3133	6	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	3133	7	that	that	IN
cord-006860-a3b8hyyr	3133	8	hypothermia	hypothermia	NN
cord-006860-a3b8hyyr	3133	9	did	do	VBD
cord-006860-a3b8hyyr	3133	10	not	not	RB
cord-006860-a3b8hyyr	3133	11	affect	affect	VB
cord-006860-a3b8hyyr	3133	12	the	the	DT
cord-006860-a3b8hyyr	3133	13	activity	activity	NN
cord-006860-a3b8hyyr	3133	14	of	of	IN
cord-006860-a3b8hyyr	3133	15	ARG	arg	NN
cord-006860-a3b8hyyr	3133	16	,	,	,
cord-006860-a3b8hyyr	3133	17	nor	nor	CC
cord-006860-a3b8hyyr	3133	18	did	do	VBD
cord-006860-a3b8hyyr	3133	19	varioos	varioos	JJ
cord-006860-a3b8hyyr	3133	20	formnlations	formnlation	NNS
cord-006860-a3b8hyyr	3133	21	.	.	.
cord-006860-a3b8hyyr	3134	1	This	this	DT
cord-006860-a3b8hyyr	3134	2	dose	dose	NN
cord-006860-a3b8hyyr	3134	3	finding	finding	NN
cord-006860-a3b8hyyr	3134	4	study	study	NN
cord-006860-a3b8hyyr	3134	5	strongly	strongly	RB
cord-006860-a3b8hyyr	3134	6	suggests	suggest	VBZ
cord-006860-a3b8hyyr	3134	7	that	that	IN
cord-006860-a3b8hyyr	3134	8	ARG	ARG	NNP
cord-006860-a3b8hyyr	3134	9	may	may	MD
cord-006860-a3b8hyyr	3134	10	be	be	VB
cord-006860-a3b8hyyr	3134	11	a	a	DT
cord-006860-a3b8hyyr	3134	12	safe	safe	JJ
cord-006860-a3b8hyyr	3134	13	and	and	CC
cord-006860-a3b8hyyr	3134	14	effective	effective	JJ
cord-006860-a3b8hyyr	3134	15	alternative	alternative	NN
cord-006860-a3b8hyyr	3134	16	to	to	IN
cord-006860-a3b8hyyr	3134	17	heparin	heparin	NN
cord-006860-a3b8hyyr	3134	18	for	for	IN
cord-006860-a3b8hyyr	3134	19	patients	patient	NNS
cord-006860-a3b8hyyr	3134	20	undergoing	undergo	VBG
cord-006860-a3b8hyyr	3134	21	CPB	CPB	NNP
cord-006860-a3b8hyyr	3134	22	.	.	.
cord-006860-a3b8hyyr	3135	1	This	this	DT
cord-006860-a3b8hyyr	3135	2	is	be	VBZ
cord-006860-a3b8hyyr	3135	3	particularly	particularly	RB
cord-006860-a3b8hyyr	3135	4	important	important	JJ
cord-006860-a3b8hyyr	3135	5	for	for	IN
cord-006860-a3b8hyyr	3135	6	the	the	DT
cord-006860-a3b8hyyr	3135	7	growing	grow	VBG
cord-006860-a3b8hyyr	3135	8	population	population	NN
cord-006860-a3b8hyyr	3135	9	of	of	IN
cord-006860-a3b8hyyr	3135	10	patients	patient	NNS
cord-006860-a3b8hyyr	3135	11	with	with	IN
cord-006860-a3b8hyyr	3135	12	HIT	hit	NN
cord-006860-a3b8hyyr	3135	13	who	who	WP
cord-006860-a3b8hyyr	3135	14	require	require	VBP
cord-006860-a3b8hyyr	3135	15	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	3135	16	surgery	surgery	NN
cord-006860-a3b8hyyr	3135	17	,	,	,
cord-006860-a3b8hyyr	3135	18	for	for	IN
cord-006860-a3b8hyyr	3135	19	which	which	WDT
cord-006860-a3b8hyyr	3135	20	no	no	DT
cord-006860-a3b8hyyr	3135	21	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3135	22	alternative	alternative	NN
cord-006860-a3b8hyyr	3135	23	is	be	VBZ
cord-006860-a3b8hyyr	3135	24	presently	presently	RB
cord-006860-a3b8hyyr	3135	25	available	available	JJ
cord-006860-a3b8hyyr	3135	26	.	.	.
cord-006860-a3b8hyyr	3136	1	Three	three	CD
cord-006860-a3b8hyyr	3136	2	recent	recent	JJ
cord-006860-a3b8hyyr	3136	3	clinical	clinical	JJ
cord-006860-a3b8hyyr	3136	4	tdals	tdal	NNS
cord-006860-a3b8hyyr	3136	5	with	with	IN
cord-006860-a3b8hyyr	3136	6	r	r	NN
cord-006860-a3b8hyyr	3136	7	-	-	:
cord-006860-a3b8hyyr	3136	8	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3136	9	(	(	-LRB-
cord-006860-a3b8hyyr	3136	10	TIMI	TIMI	NNP
cord-006860-a3b8hyyr	3136	11	9	9	CD
cord-006860-a3b8hyyr	3136	12	,	,	,
cord-006860-a3b8hyyr	3136	13	GUSTO	GUSTO	NNP
cord-006860-a3b8hyyr	3136	14	2	2	CD
cord-006860-a3b8hyyr	3136	15	and	and	CC
cord-006860-a3b8hyyr	3136	16	HIT	hit	VB
cord-006860-a3b8hyyr	3136	17	)	)	-RRB-
cord-006860-a3b8hyyr	3136	18	have	have	VBP
cord-006860-a3b8hyyr	3136	19	shown	show	VBN
cord-006860-a3b8hyyr	3136	20	that	that	IN
cord-006860-a3b8hyyr	3136	21	the	the	DT
cord-006860-a3b8hyyr	3136	22	risk	risk	NN
cord-006860-a3b8hyyr	3136	23	of	of	IN
cord-006860-a3b8hyyr	3136	24	severe	severe	JJ
cord-006860-a3b8hyyr	3136	25	haemorrhagic	haemorrhagic	JJ
cord-006860-a3b8hyyr	3136	26	side	side	NN
cord-006860-a3b8hyyr	3136	27	effects	effect	NNS
cord-006860-a3b8hyyr	3136	28	was	be	VBD
cord-006860-a3b8hyyr	3136	29	strongly	strongly	RB
cord-006860-a3b8hyyr	3136	30	associated	associate	VBN
cord-006860-a3b8hyyr	3136	31	with	with	IN
cord-006860-a3b8hyyr	3136	32	high	high	JJ
cord-006860-a3b8hyyr	3136	33	aPTT	aPTT	NNS
cord-006860-a3b8hyyr	3136	34	-	-	HYPH
cord-006860-a3b8hyyr	3136	35	levels	level	NNS
cord-006860-a3b8hyyr	3136	36	.	.	.
cord-006860-a3b8hyyr	3137	1	The	the	DT
cord-006860-a3b8hyyr	3137	2	large	large	JJ
cord-006860-a3b8hyyr	3137	3	intedndividual	intedndividual	JJ
cord-006860-a3b8hyyr	3137	4	variability	variability	NN
cord-006860-a3b8hyyr	3137	5	of	of	IN
cord-006860-a3b8hyyr	3137	6	the	the	DT
cord-006860-a3b8hyyr	3137	7	aPTT	aptt	NN
cord-006860-a3b8hyyr	3137	8	and	and	CC
cord-006860-a3b8hyyr	3137	9	the	the	DT
cord-006860-a3b8hyyr	3137	10	lack	lack	NN
cord-006860-a3b8hyyr	3137	11	of	of	IN
cord-006860-a3b8hyyr	3137	12	a	a	DT
cord-006860-a3b8hyyr	3137	13	linear	linear	JJ
cord-006860-a3b8hyyr	3137	14	dose	dose	JJ
cord-006860-a3b8hyyr	3137	15	-	-	HYPH
cord-006860-a3b8hyyr	3137	16	effect	effect	NN
cord-006860-a3b8hyyr	3137	17	ratio	ratio	NN
cord-006860-a3b8hyyr	3137	18	,	,	,
cord-006860-a3b8hyyr	3137	19	however	however	RB
cord-006860-a3b8hyyr	3137	20	,	,	,
cord-006860-a3b8hyyr	3137	21	limits	limit	VBZ
cord-006860-a3b8hyyr	3137	22	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3137	23	value	value	NN
cord-006860-a3b8hyyr	3137	24	for	for	IN
cord-006860-a3b8hyyr	3137	25	reliable	reliable	JJ
cord-006860-a3b8hyyr	3137	26	monitoring	monitoring	NN
cord-006860-a3b8hyyr	3137	27	of	of	IN
cord-006860-a3b8hyyr	3137	28	the	the	DT
cord-006860-a3b8hyyr	3137	29	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3137	30	effect	effect	NN
cord-006860-a3b8hyyr	3137	31	of	of	IN
cord-006860-a3b8hyyr	3137	32	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3137	33	since	since	IN
cord-006860-a3b8hyyr	3137	34	even	even	RB
cord-006860-a3b8hyyr	3137	35	severe	severe	JJ
cord-006860-a3b8hyyr	3137	36	overdosage	overdosage	NN
cord-006860-a3b8hyyr	3137	37	due	due	IN
cord-006860-a3b8hyyr	3137	38	to	to	IN
cord-006860-a3b8hyyr	3137	39	impaired	impaired	JJ
cord-006860-a3b8hyyr	3137	40	renal	renal	JJ
cord-006860-a3b8hyyr	3137	41	elimination	elimination	NN
cord-006860-a3b8hyyr	3137	42	may	may	MD
cord-006860-a3b8hyyr	3137	43	not	not	RB
cord-006860-a3b8hyyr	3137	44	be	be	VB
cord-006860-a3b8hyyr	3137	45	detected	detect	VBN
cord-006860-a3b8hyyr	3137	46	with	with	IN
cord-006860-a3b8hyyr	3137	47	this	this	DT
cord-006860-a3b8hyyr	3137	48	assay	assay	NN
cord-006860-a3b8hyyr	3137	49	.	.	.
cord-006860-a3b8hyyr	3138	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3138	2	have	have	VBP
cord-006860-a3b8hyyr	3138	3	therefore	therefore	RB
cord-006860-a3b8hyyr	3138	4	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	3138	5	the	the	DT
cord-006860-a3b8hyyr	3138	6	ecadn	ecadn	JJ
cord-006860-a3b8hyyr	3138	7	clotting	clotting	NN
cord-006860-a3b8hyyr	3138	8	time	time	NN
cord-006860-a3b8hyyr	3138	9	(	(	-LRB-
cord-006860-a3b8hyyr	3138	10	ECT	ECT	NNP
cord-006860-a3b8hyyr	3138	11	)	)	-RRB-
cord-006860-a3b8hyyr	3138	12	as	as	IN
cord-006860-a3b8hyyr	3138	13	descdbed	descdbe	VBN
cord-006860-a3b8hyyr	3138	14	by	by	IN
cord-006860-a3b8hyyr	3138	15	Nowak	Nowak	NNP
cord-006860-a3b8hyyr	3138	16	and	and	CC
cord-006860-a3b8hyyr	3138	17	Bucha	Bucha	NNP
cord-006860-a3b8hyyr	3138	18	(	(	-LRB-
cord-006860-a3b8hyyr	3138	19	Thromb	Thromb	NNP
cord-006860-a3b8hyyr	3138	20	.	.	.
cord-006860-a3b8hyyr	3139	1	Haemost	Haemost	NNP
cord-006860-a3b8hyyr	3139	2	.	.	.
cord-006860-a3b8hyyr	3139	3	1993	1993	CD
cord-006860-a3b8hyyr	3139	4	;	;	:
cord-006860-a3b8hyyr	3139	5	69	69	CD
cord-006860-a3b8hyyr	3139	6	:	:	SYM
cord-006860-a3b8hyyr	3139	7	1306	1306	CD
cord-006860-a3b8hyyr	3139	8	)	)	-RRB-
cord-006860-a3b8hyyr	3139	9	under	under	IN
cord-006860-a3b8hyyr	3139	10	conditions	condition	NNS
cord-006860-a3b8hyyr	3139	11	which	which	WDT
cord-006860-a3b8hyyr	3139	12	allow	allow	VBP
cord-006860-a3b8hyyr	3139	13	conclusions	conclusion	NNS
cord-006860-a3b8hyyr	3139	14	on	on	IN
cord-006860-a3b8hyyr	3139	15	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3139	16	reliability	reliability	NN
cord-006860-a3b8hyyr	3139	17	in	in	IN
cord-006860-a3b8hyyr	3139	18	the	the	DT
cord-006860-a3b8hyyr	3139	19	clinical	clinical	JJ
cord-006860-a3b8hyyr	3139	20	situation	situation	NN
cord-006860-a3b8hyyr	3139	21	.	.	.
cord-006860-a3b8hyyr	3140	1	For	for	IN
cord-006860-a3b8hyyr	3140	2	this	this	DT
cord-006860-a3b8hyyr	3140	3	,	,	,
cord-006860-a3b8hyyr	3140	4	citrated	citrate	VBN
cord-006860-a3b8hyyr	3140	5	venous	venous	JJ
cord-006860-a3b8hyyr	3140	6	blood	blood	NN
cord-006860-a3b8hyyr	3140	7	obtained	obtain	VBN
cord-006860-a3b8hyyr	3140	8	from	from	IN
cord-006860-a3b8hyyr	3140	9	healthy	healthy	JJ
cord-006860-a3b8hyyr	3140	10	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	3140	11	,	,	,
cord-006860-a3b8hyyr	3140	12	patients	patient	NNS
cord-006860-a3b8hyyr	3140	13	with	with	IN
cord-006860-a3b8hyyr	3140	14	unstable	unstable	JJ
cord-006860-a3b8hyyr	3140	15	angina	angina	NN
cord-006860-a3b8hyyr	3140	16	pectoris	pectoris	NN
cord-006860-a3b8hyyr	3140	17	,	,	,
cord-006860-a3b8hyyr	3140	18	and	and	CC
cord-006860-a3b8hyyr	3140	19	patients	patient	NNS
cord-006860-a3b8hyyr	3140	20	treated	treat	VBN
cord-006860-a3b8hyyr	3140	21	with	with	IN
cord-006860-a3b8hyyr	3140	22	marcumar	marcumar	NNP
cord-006860-a3b8hyyr	3140	23	was	be	VBD
cord-006860-a3b8hyyr	3140	24	supplemented	supplement	VBN
cord-006860-a3b8hyyr	3140	25	with	with	IN
cord-006860-a3b8hyyr	3140	26	different	different	JJ
cord-006860-a3b8hyyr	3140	27	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3140	28	of	of	IN
cord-006860-a3b8hyyr	3140	29	PEGhirudin	PEGhirudin	NNS
cord-006860-a3b8hyyr	3140	30	.	.	.
cord-006860-a3b8hyyr	3141	1	Measurements	measurement	NNS
cord-006860-a3b8hyyr	3141	2	of	of	IN
cord-006860-a3b8hyyr	3141	3	aPTT	aptt	NN
cord-006860-a3b8hyyr	3141	4	and	and	CC
cord-006860-a3b8hyyr	3141	5	ECT	ECT	NNP
cord-006860-a3b8hyyr	3141	6	were	be	VBD
cord-006860-a3b8hyyr	3141	7	made	make	VBN
cord-006860-a3b8hyyr	3141	8	in	in	IN
cord-006860-a3b8hyyr	3141	9	duplicate	duplicate	NN
cord-006860-a3b8hyyr	3141	10	.	.	.
cord-006860-a3b8hyyr	3142	1	In	in	IN
cord-006860-a3b8hyyr	3142	2	contrast	contrast	NN
cord-006860-a3b8hyyr	3142	3	to	to	IN
cord-006860-a3b8hyyr	3142	4	the	the	DT
cord-006860-a3b8hyyr	3142	5	aPTT	aptt	NN
cord-006860-a3b8hyyr	3142	6	,	,	,
cord-006860-a3b8hyyr	3142	7	the	the	DT
cord-006860-a3b8hyyr	3142	8	ECT	ECT	NNPS
cord-006860-a3b8hyyr	3142	9	showed	show	VBD
cord-006860-a3b8hyyr	3142	10	a	a	DT
cord-006860-a3b8hyyr	3142	11	close	close	JJ
cord-006860-a3b8hyyr	3142	12	,	,	,
cord-006860-a3b8hyyr	3142	13	linear	linear	JJ
cord-006860-a3b8hyyr	3142	14	relationship	relationship	NN
cord-006860-a3b8hyyr	3142	15	with	with	IN
cord-006860-a3b8hyyr	3142	16	PEG	peg	NN
cord-006860-a3b8hyyr	3142	17	-	-	HYPH
cord-006860-a3b8hyyr	3142	18	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3142	19	plasma	plasma	NN
cord-006860-a3b8hyyr	3142	20	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3142	21	in	in	IN
cord-006860-a3b8hyyr	3142	22	the	the	DT
cord-006860-a3b8hyyr	3142	23	range	range	NN
cord-006860-a3b8hyyr	3142	24	of	of	IN
cord-006860-a3b8hyyr	3142	25	100	100	CD
cord-006860-a3b8hyyr	3142	26	and	and	CC
cord-006860-a3b8hyyr	3142	27	10	10	CD
cord-006860-a3b8hyyr	3142	28	000	000	CD
cord-006860-a3b8hyyr	3142	29	ng	ng	NN
cord-006860-a3b8hyyr	3142	30	/	/	SYM
cord-006860-a3b8hyyr	3142	31	ml	ml	NN
cord-006860-a3b8hyyr	3142	32	.	.	.
cord-006860-a3b8hyyr	3143	1	The	the	DT
cord-006860-a3b8hyyr	3143	2	lineadty	lineadty	NN
cord-006860-a3b8hyyr	3143	3	of	of	IN
cord-006860-a3b8hyyr	3143	4	this	this	DT
cord-006860-a3b8hyyr	3143	5	relationship	relationship	NN
cord-006860-a3b8hyyr	3143	6	was	be	VBD
cord-006860-a3b8hyyr	3143	7	not	not	RB
cord-006860-a3b8hyyr	3143	8	affected	affect	VBN
cord-006860-a3b8hyyr	3143	9	by	by	IN
cord-006860-a3b8hyyr	3143	10	the	the	DT
cord-006860-a3b8hyyr	3143	11	presence	presence	NN
cord-006860-a3b8hyyr	3143	12	of	of	IN
cord-006860-a3b8hyyr	3143	13	unfractionated	unfractionated	JJ
cord-006860-a3b8hyyr	3143	14	or	or	CC
cord-006860-a3b8hyyr	3143	15	low	low	JJ
cord-006860-a3b8hyyr	3143	16	molecular	molecular	JJ
cord-006860-a3b8hyyr	3143	17	weight	weight	NN
cord-006860-a3b8hyyr	3143	18	hepadns	hepadns	NN
cord-006860-a3b8hyyr	3143	19	in	in	IN
cord-006860-a3b8hyyr	3143	20	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3143	21	of	of	IN
cord-006860-a3b8hyyr	3143	22	up	up	IN
cord-006860-a3b8hyyr	3143	23	to	to	TO
cord-006860-a3b8hyyr	3143	24	10	10	CD
cord-006860-a3b8hyyr	3143	25	pg	pg	NN
cord-006860-a3b8hyyr	3143	26	/	/	SYM
cord-006860-a3b8hyyr	3143	27	ml	ml	NN
cord-006860-a3b8hyyr	3143	28	.	.	.
cord-006860-a3b8hyyr	3144	1	The	the	DT
cord-006860-a3b8hyyr	3144	2	ECT	ECT	NNP
cord-006860-a3b8hyyr	3144	3	was	be	VBD
cord-006860-a3b8hyyr	3144	4	not	not	RB
cord-006860-a3b8hyyr	3144	5	affected	affect	VBN
cord-006860-a3b8hyyr	3144	6	by	by	IN
cord-006860-a3b8hyyr	3144	7	fibdnogen	fibdnogen	NNP
cord-006860-a3b8hyyr	3144	8	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3144	9	60	60	CD
cord-006860-a3b8hyyr	3144	10	%	%	NN
cord-006860-a3b8hyyr	3144	11	below	below	IN
cord-006860-a3b8hyyr	3144	12	normal	normal	JJ
cord-006860-a3b8hyyr	3144	13	.	.	.
cord-006860-a3b8hyyr	3145	1	A	a	DT
cord-006860-a3b8hyyr	3145	2	somewhat	somewhat	RB
cord-006860-a3b8hyyr	3145	3	higher	high	JJR
cord-006860-a3b8hyyr	3145	4	slope	slope	NN
cord-006860-a3b8hyyr	3145	5	but	but	CC
cord-006860-a3b8hyyr	3146	1	no	no	DT
cord-006860-a3b8hyyr	3146	2	change	change	NN
cord-006860-a3b8hyyr	3146	3	in	in	IN
cord-006860-a3b8hyyr	3146	4	linearity	linearity	NN
cord-006860-a3b8hyyr	3146	5	was	be	VBD
cord-006860-a3b8hyyr	3146	6	found	find	VBN
cord-006860-a3b8hyyr	3146	7	in	in	IN
cord-006860-a3b8hyyr	3146	8	plasma	plasma	NN
cord-006860-a3b8hyyr	3146	9	from	from	IN
cord-006860-a3b8hyyr	3146	10	marcumar	marcumar	NN
cord-006860-a3b8hyyr	3146	11	-	-	HYPH
cord-006860-a3b8hyyr	3146	12	patients	patient	NNS
cord-006860-a3b8hyyr	3146	13	with	with	IN
cord-006860-a3b8hyyr	3146	14	quick	quick	JJ
cord-006860-a3b8hyyr	3146	15	-	-	HYPH
cord-006860-a3b8hyyr	3146	16	values	value	NNS
cord-006860-a3b8hyyr	3146	17	between	between	IN
cord-006860-a3b8hyyr	3146	18	20	20	CD
cord-006860-a3b8hyyr	3146	19	and	and	CC
cord-006860-a3b8hyyr	3146	20	32	32	CD
cord-006860-a3b8hyyr	3146	21	%	%	NN
cord-006860-a3b8hyyr	3146	22	.	.	.
cord-006860-a3b8hyyr	3147	1	No	no	DT
cord-006860-a3b8hyyr	3147	2	significant	significant	JJ
cord-006860-a3b8hyyr	3147	3	differences	difference	NNS
cord-006860-a3b8hyyr	3147	4	were	be	VBD
cord-006860-a3b8hyyr	3147	5	found	find	VBN
cord-006860-a3b8hyyr	3147	6	between	between	IN
cord-006860-a3b8hyyr	3147	7	values	value	NNS
cord-006860-a3b8hyyr	3147	8	measured	measure	VBN
cord-006860-a3b8hyyr	3147	9	in	in	IN
cord-006860-a3b8hyyr	3147	10	citrated	citrate	VBN
cord-006860-a3b8hyyr	3147	11	blood	blood	NN
cord-006860-a3b8hyyr	3147	12	or	or	CC
cord-006860-a3b8hyyr	3147	13	plasma	plasma	NN
cord-006860-a3b8hyyr	3147	14	or	or	CC
cord-006860-a3b8hyyr	3147	15	using	use	VBG
cord-006860-a3b8hyyr	3147	16	different	different	JJ
cord-006860-a3b8hyyr	3147	17	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3147	18	timers	timer	NNS
cord-006860-a3b8hyyr	3147	19	.	.	.
cord-006860-a3b8hyyr	3148	1	The	the	DT
cord-006860-a3b8hyyr	3148	2	most	most	RBS
cord-006860-a3b8hyyr	3148	3	potent	potent	JJ
cord-006860-a3b8hyyr	3148	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3148	5	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3148	6	containing	contain	VBG
cord-006860-a3b8hyyr	3148	7	a	a	DT
cord-006860-a3b8hyyr	3148	8	benzamidine	benzamidine	NN
cord-006860-a3b8hyyr	3148	9	moiety	moiety	NN
cord-006860-a3b8hyyr	3148	10	is	be	VBZ
cord-006860-a3b8hyyr	3148	11	NAPAP	NAPAP	NNP
cord-006860-a3b8hyyr	3148	12	(	(	-LRB-
cord-006860-a3b8hyyr	3148	13	K	K	NNP
cord-006860-a3b8hyyr	3148	14	i	i	NN
cord-006860-a3b8hyyr	3148	15	=	=	SYM
cord-006860-a3b8hyyr	3148	16	6	6	CD
cord-006860-a3b8hyyr	3148	17	nmol	nmol	NN
cord-006860-a3b8hyyr	3148	18	/	/	,
cord-006860-a3b8hyyr	3148	19	I	i	NN
cord-006860-a3b8hyyr	3148	20	)	)	-RRB-
cord-006860-a3b8hyyr	3148	21	.	.	.
cord-006860-a3b8hyyr	3149	1	Unfortunately	unfortunately	RB
cord-006860-a3b8hyyr	3149	2	,	,	,
cord-006860-a3b8hyyr	3149	3	the	the	DT
cord-006860-a3b8hyyr	3149	4	pharmacokinetic	pharmacokinetic	JJ
cord-006860-a3b8hyyr	3149	5	properties	property	NNS
cord-006860-a3b8hyyr	3149	6	(	(	-LRB-
cord-006860-a3b8hyyr	3149	7	fast	fast	JJ
cord-006860-a3b8hyyr	3149	8	elimination	elimination	NN
cord-006860-a3b8hyyr	3149	9	by	by	IN
cord-006860-a3b8hyyr	3149	10	hepatic	hepatic	JJ
cord-006860-a3b8hyyr	3149	11	uptake	uptake	NN
cord-006860-a3b8hyyr	3149	12	and	and	CC
cord-006860-a3b8hyyr	3149	13	biliary	biliary	JJ
cord-006860-a3b8hyyr	3149	14	excretion	excretion	NN
cord-006860-a3b8hyyr	3149	15	,	,	,
cord-006860-a3b8hyyr	3149	16	poor	poor	JJ
cord-006860-a3b8hyyr	3149	17	enteral	enteral	JJ
cord-006860-a3b8hyyr	3149	18	absorption	absorption	NN
cord-006860-a3b8hyyr	3149	19	)	)	-RRB-
cord-006860-a3b8hyyr	3149	20	are	be	VBP
cord-006860-a3b8hyyr	3149	21	unsuitable	unsuitable	JJ
cord-006860-a3b8hyyr	3149	22	for	for	IN
cord-006860-a3b8hyyr	3149	23	the	the	DT
cord-006860-a3b8hyyr	3149	24	use	use	NN
cord-006860-a3b8hyyr	3149	25	of	of	IN
cord-006860-a3b8hyyr	3149	26	NAPAP	NAPAP	NNP
cord-006860-a3b8hyyr	3149	27	as	as	IN
cord-006860-a3b8hyyr	3149	28	an	an	DT
cord-006860-a3b8hyyr	3149	29	oral	oral	JJ
cord-006860-a3b8hyyr	3149	30	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3149	31	.	.	.
cord-006860-a3b8hyyr	3150	1	The	the	DT
cord-006860-a3b8hyyr	3150	2	application	application	NN
cord-006860-a3b8hyyr	3150	3	of	of	IN
cord-006860-a3b8hyyr	3150	4	choice	choice	NN
cord-006860-a3b8hyyr	3150	5	of	of	IN
cord-006860-a3b8hyyr	3150	6	a	a	DT
cord-006860-a3b8hyyr	3150	7	synthetic	synthetic	JJ
cord-006860-a3b8hyyr	3150	8	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3150	9	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3150	10	would	would	MD
cord-006860-a3b8hyyr	3150	11	be	be	VB
cord-006860-a3b8hyyr	3150	12	the	the	DT
cord-006860-a3b8hyyr	3150	13	oral	oral	JJ
cord-006860-a3b8hyyr	3150	14	one	one	NN
cord-006860-a3b8hyyr	3150	15	,	,	,
cord-006860-a3b8hyyr	3150	16	Therefore	therefore	RB
cord-006860-a3b8hyyr	3150	17	,	,	,
cord-006860-a3b8hyyr	3150	18	we	-PRON-	PRP
cord-006860-a3b8hyyr	3150	19	looked	look	VBD
cord-006860-a3b8hyyr	3150	20	for	for	IN
cord-006860-a3b8hyyr	3150	21	other	other	JJ
cord-006860-a3b8hyyr	3150	22	lead	lead	JJ
cord-006860-a3b8hyyr	3150	23	structures	structure	NNS
cord-006860-a3b8hyyr	3150	24	.	.	.
cord-006860-a3b8hyyr	3151	1	With	with	IN
cord-006860-a3b8hyyr	3151	2	the	the	DT
cord-006860-a3b8hyyr	3151	3	Nc~-arylsulfonylated	nc~-arylsulfonylated	CD
cord-006860-a3b8hyyr	3151	4	piperazides	piperazide	NNS
cord-006860-a3b8hyyr	3151	5	of	of	IN
cord-006860-a3b8hyyr	3151	6	3-amidinophenylalanine	3-amidinophenylalanine	CD
cord-006860-a3b8hyyr	3151	7	we	-PRON-	PRP
cord-006860-a3b8hyyr	3151	8	found	find	VBD
cord-006860-a3b8hyyr	3151	9	a	a	DT
cord-006860-a3b8hyyr	3151	10	new	new	JJ
cord-006860-a3b8hyyr	3151	11	group	group	NN
cord-006860-a3b8hyyr	3151	12	of	of	IN
cord-006860-a3b8hyyr	3151	13	derivatives	derivative	NNS
cord-006860-a3b8hyyr	3151	14	which	which	WDT
cord-006860-a3b8hyyr	3151	15	inhibit	inhibit	VBP
cord-006860-a3b8hyyr	3151	16	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3151	17	with	with	IN
cord-006860-a3b8hyyr	3151	18	Ki	Ki	NNP
cord-006860-a3b8hyyr	3151	19	-	-	HYPH
cord-006860-a3b8hyyr	3151	20	values	value	NNS
cord-006860-a3b8hyyr	3151	21	in	in	IN
cord-006860-a3b8hyyr	3151	22	the	the	DT
cord-006860-a3b8hyyr	3151	23	nanomolar	nanomolar	JJ
cord-006860-a3b8hyyr	3151	24	range	range	NN
cord-006860-a3b8hyyr	3151	25	.	.	.
cord-006860-a3b8hyyr	3152	1	The	the	DT
cord-006860-a3b8hyyr	3152	2	piperazides	piperazide	NNS
cord-006860-a3b8hyyr	3152	3	exert	exert	VBP
cord-006860-a3b8hyyr	3152	4	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3152	5	activities	activity	NNS
cord-006860-a3b8hyyr	3152	6	with	with	IN
cord-006860-a3b8hyyr	3152	7	high	high	JJ
cord-006860-a3b8hyyr	3152	8	selectivity	selectivity	NN
cord-006860-a3b8hyyr	3152	9	,	,	,
cord-006860-a3b8hyyr	3152	10	leaving	leave	VBG
cord-006860-a3b8hyyr	3152	11	activated	activate	VBN
cord-006860-a3b8hyyr	3152	12	protein	protein	NN
cord-006860-a3b8hyyr	3152	13	C	c	NN
cord-006860-a3b8hyyr	3152	14	and	and	CC
cord-006860-a3b8hyyr	3152	15	components	component	NNS
cord-006860-a3b8hyyr	3152	16	of	of	IN
cord-006860-a3b8hyyr	3152	17	the	the	DT
cord-006860-a3b8hyyr	3152	18	fibdnolytic	fibdnolytic	JJ
cord-006860-a3b8hyyr	3152	19	system	system	NN
cord-006860-a3b8hyyr	3152	20	unaffected	unaffected	JJ
cord-006860-a3b8hyyr	3152	21	.	.	.
cord-006860-a3b8hyyr	3153	1	In	in	IN
cord-006860-a3b8hyyr	3153	2	rats	rat	NNS
cord-006860-a3b8hyyr	3153	3	,	,	,
cord-006860-a3b8hyyr	3153	4	the	the	DT
cord-006860-a3b8hyyr	3153	5	piperazides	piperazide	NNS
cord-006860-a3b8hyyr	3153	6	are	be	VBP
cord-006860-a3b8hyyr	3153	7	rapidly	rapidly	RB
cord-006860-a3b8hyyr	3153	8	eliminated	eliminate	VBN
cord-006860-a3b8hyyr	3153	9	from	from	IN
cord-006860-a3b8hyyr	3153	10	the	the	DT
cord-006860-a3b8hyyr	3153	11	circulation	circulation	NN
cord-006860-a3b8hyyr	3153	12	(	(	-LRB-
cord-006860-a3b8hyyr	3153	13	tl/2	tl/2	NNP
cord-006860-a3b8hyyr	3153	14	~	~	NFP
cord-006860-a3b8hyyr	3153	15	10	10	CD
cord-006860-a3b8hyyr	3153	16	min	min	NN
cord-006860-a3b8hyyr	3153	17	)	)	-RRB-
cord-006860-a3b8hyyr	3153	18	upon	upon	IN
cord-006860-a3b8hyyr	3153	19	i.v	i.v	NNP
cord-006860-a3b8hyyr	3153	20	.	.	NNP
cord-006860-a3b8hyyr	3153	21	administration	administration	NN
cord-006860-a3b8hyyr	3153	22	,	,	,
cord-006860-a3b8hyyr	3153	23	too	too	RB
cord-006860-a3b8hyyr	3153	24	.	.	.
cord-006860-a3b8hyyr	3154	1	After	after	IN
cord-006860-a3b8hyyr	3154	2	oral	oral	JJ
cord-006860-a3b8hyyr	3154	3	administration	administration	NN
cord-006860-a3b8hyyr	3154	4	,	,	,
cord-006860-a3b8hyyr	3154	5	the	the	DT
cord-006860-a3b8hyyr	3154	6	systemic	systemic	JJ
cord-006860-a3b8hyyr	3154	7	bioavailability	bioavailability	NN
cord-006860-a3b8hyyr	3154	8	is	be	VBZ
cord-006860-a3b8hyyr	3154	9	low	low	JJ
cord-006860-a3b8hyyr	3154	10	.	.	.
cord-006860-a3b8hyyr	3155	1	Upon	upon	IN
cord-006860-a3b8hyyr	3155	2	intraduodenal	intraduodenal	NNP
cord-006860-a3b8hyyr	3155	3	administration	administration	NN
cord-006860-a3b8hyyr	3155	4	of	of	IN
cord-006860-a3b8hyyr	3155	5	high	high	JJ
cord-006860-a3b8hyyr	3155	6	doses	dose	NNS
cord-006860-a3b8hyyr	3155	7	widely	widely	RB
cord-006860-a3b8hyyr	3155	8	varying	vary	VBG
cord-006860-a3b8hyyr	3155	9	blood	blood	NN
cord-006860-a3b8hyyr	3155	10	levels	level	NNS
cord-006860-a3b8hyyr	3155	11	were	be	VBD
cord-006860-a3b8hyyr	3155	12	seen	see	VBN
cord-006860-a3b8hyyr	3155	13	,	,	,
cord-006860-a3b8hyyr	3155	14	depending	depend	VBG
cord-006860-a3b8hyyr	3155	15	on	on	IN
cord-006860-a3b8hyyr	3155	16	the	the	DT
cord-006860-a3b8hyyr	3155	17	mode	mode	NN
cord-006860-a3b8hyyr	3155	18	of	of	IN
cord-006860-a3b8hyyr	3155	19	administration	administration	NN
cord-006860-a3b8hyyr	3155	20	.	.	.
cord-006860-a3b8hyyr	3156	1	To	to	TO
cord-006860-a3b8hyyr	3156	2	cladfy	cladfy	VB
cord-006860-a3b8hyyr	3156	3	the	the	DT
cord-006860-a3b8hyyr	3156	4	importance	importance	NN
cord-006860-a3b8hyyr	3156	5	of	of	IN
cord-006860-a3b8hyyr	3156	6	a	a	DT
cord-006860-a3b8hyyr	3156	7	possible	possible	JJ
cord-006860-a3b8hyyr	3156	8	hepatic	hepatic	JJ
cord-006860-a3b8hyyr	3156	9	first	first	JJ
cord-006860-a3b8hyyr	3156	10	pass	pass	NN
cord-006860-a3b8hyyr	3156	11	effect	effect	NN
cord-006860-a3b8hyyr	3156	12	we	-PRON-	PRP
cord-006860-a3b8hyyr	3156	13	studied	study	VBD
cord-006860-a3b8hyyr	3156	14	in	in	IN
cord-006860-a3b8hyyr	3156	15	more	more	JJR
cord-006860-a3b8hyyr	3156	16	detail	detail	NN
cord-006860-a3b8hyyr	3156	17	the	the	DT
cord-006860-a3b8hyyr	3156	18	pharmacokinetics	pharmacokinetic	NNS
cord-006860-a3b8hyyr	3156	19	of	of	IN
cord-006860-a3b8hyyr	3156	20	the	the	DT
cord-006860-a3b8hyyr	3156	21	N~-(2naphthylsulfonyl)-3-amidinophenylalanine	n~-(2naphthylsulfonyl)-3-amidinophenylalanine	CD
cord-006860-a3b8hyyr	3156	22	N'-acetylpiperazide	n'-acetylpiperazide	NN
cord-006860-a3b8hyyr	3156	23	in	in	IN
cord-006860-a3b8hyyr	3156	24	rats	rat	NNS
cord-006860-a3b8hyyr	3156	25	using	use	VBG
cord-006860-a3b8hyyr	3156	26	HPLC	HPLC	NNP
cord-006860-a3b8hyyr	3156	27	-	-	HYPH
cord-006860-a3b8hyyr	3156	28	analysis	analysis	NN
cord-006860-a3b8hyyr	3156	29	.	.	.
cord-006860-a3b8hyyr	3157	1	Like	like	IN
cord-006860-a3b8hyyr	3157	2	other	other	JJ
cord-006860-a3b8hyyr	3157	3	benzamidines	benzamidine	NNS
cord-006860-a3b8hyyr	3157	4	the	the	DT
cord-006860-a3b8hyyr	3157	5	piperazide	piperazide	NN
cord-006860-a3b8hyyr	3157	6	is	be	VBZ
cord-006860-a3b8hyyr	3157	7	excreted	excrete	VBN
cord-006860-a3b8hyyr	3157	8	via	via	IN
cord-006860-a3b8hyyr	3157	9	the	the	DT
cord-006860-a3b8hyyr	3157	10	bile	bile	NN
cord-006860-a3b8hyyr	3157	11	to	to	IN
cord-006860-a3b8hyyr	3157	12	a	a	DT
cord-006860-a3b8hyyr	3157	13	high	high	JJ
cord-006860-a3b8hyyr	3157	14	extent	extent	NN
cord-006860-a3b8hyyr	3157	15	.	.	.
cord-006860-a3b8hyyr	3158	1	Enteral	enteral	JJ
cord-006860-a3b8hyyr	3158	2	absorption	absorption	NN
cord-006860-a3b8hyyr	3158	3	rates	rate	NNS
cord-006860-a3b8hyyr	3158	4	of	of	IN
cord-006860-a3b8hyyr	3158	5	about	about	RB
cord-006860-a3b8hyyr	3158	6	20	20	CD
cord-006860-a3b8hyyr	3158	7	%	%	NN
cord-006860-a3b8hyyr	3158	8	are	be	VBP
cord-006860-a3b8hyyr	3158	9	found	find	VBN
cord-006860-a3b8hyyr	3158	10	after	after	IN
cord-006860-a3b8hyyr	3158	11	blocking	block	VBG
cord-006860-a3b8hyyr	3158	12	the	the	DT
cord-006860-a3b8hyyr	3158	13	hepatic	hepatic	JJ
cord-006860-a3b8hyyr	3158	14	uptake	uptake	NN
cord-006860-a3b8hyyr	3158	15	and	and	CC
cord-006860-a3b8hyyr	3158	16	biliary	biliary	JJ
cord-006860-a3b8hyyr	3158	17	excretion	excretion	NN
cord-006860-a3b8hyyr	3158	18	.	.	.
cord-006860-a3b8hyyr	3159	1	Hence	hence	RB
cord-006860-a3b8hyyr	3159	2	,	,	,
cord-006860-a3b8hyyr	3159	3	a	a	DT
cord-006860-a3b8hyyr	3159	4	hepatic	hepatic	JJ
cord-006860-a3b8hyyr	3159	5	first	first	JJ
cord-006860-a3b8hyyr	3159	6	pass	pass	NN
cord-006860-a3b8hyyr	3159	7	effect	effect	NN
cord-006860-a3b8hyyr	3159	8	appears	appear	VBZ
cord-006860-a3b8hyyr	3159	9	to	to	TO
cord-006860-a3b8hyyr	3159	10	be	be	VB
cord-006860-a3b8hyyr	3159	11	the	the	DT
cord-006860-a3b8hyyr	3159	12	main	main	JJ
cord-006860-a3b8hyyr	3159	13	reason	reason	NN
cord-006860-a3b8hyyr	3159	14	for	for	IN
cord-006860-a3b8hyyr	3159	15	low	low	JJ
cord-006860-a3b8hyyr	3159	16	systemic	systemic	JJ
cord-006860-a3b8hyyr	3159	17	bioavailability	bioavailability	NN
cord-006860-a3b8hyyr	3159	18	after	after	IN
cord-006860-a3b8hyyr	3159	19	orallenteral	orallenteral	NNP
cord-006860-a3b8hyyr	3159	20	administration	administration	NNP
cord-006860-a3b8hyyr	3159	21	.	.	.
cord-006860-a3b8hyyr	3160	1	At	at	IN
cord-006860-a3b8hyyr	3160	2	the	the	DT
cord-006860-a3b8hyyr	3160	3	same	same	JJ
cord-006860-a3b8hyyr	3160	4	time	time	NN
cord-006860-a3b8hyyr	3160	5	,	,	,
cord-006860-a3b8hyyr	3160	6	fast	fast	JJ
cord-006860-a3b8hyyr	3160	7	elimination	elimination	NN
cord-006860-a3b8hyyr	3160	8	from	from	IN
cord-006860-a3b8hyyr	3160	9	the	the	DT
cord-006860-a3b8hyyr	3160	10	circulation	circulation	NN
cord-006860-a3b8hyyr	3160	11	by	by	IN
cord-006860-a3b8hyyr	3160	12	hepatic	hepatic	JJ
cord-006860-a3b8hyyr	3160	13	uptake	uptake	NN
cord-006860-a3b8hyyr	3160	14	is	be	VBZ
cord-006860-a3b8hyyr	3160	15	the	the	DT
cord-006860-a3b8hyyr	3160	16	main	main	JJ
cord-006860-a3b8hyyr	3160	17	problem	problem	NN
cord-006860-a3b8hyyr	3160	18	for	for	IN
cord-006860-a3b8hyyr	3160	19	maintaining	maintain	VBG
cord-006860-a3b8hyyr	3160	20	effective	effective	JJ
cord-006860-a3b8hyyr	3160	21	blood	blood	NN
cord-006860-a3b8hyyr	3160	22	levels	level	NNS
cord-006860-a3b8hyyr	3160	23	with	with	IN
cord-006860-a3b8hyyr	3160	24	benzamidines	benzamidine	NNS
cord-006860-a3b8hyyr	3160	25	.	.	.
cord-006860-a3b8hyyr	3161	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	3161	2	,	,	,
cord-006860-a3b8hyyr	3161	3	the	the	DT
cord-006860-a3b8hyyr	3161	4	elucidation	elucidation	NN
cord-006860-a3b8hyyr	3161	5	of	of	IN
cord-006860-a3b8hyyr	3161	6	the	the	DT
cord-006860-a3b8hyyr	3161	7	structural	structural	JJ
cord-006860-a3b8hyyr	3161	8	elements	element	NNS
cord-006860-a3b8hyyr	3161	9	influencing	influence	VBG
cord-006860-a3b8hyyr	3161	10	the	the	DT
cord-006860-a3b8hyyr	3161	11	absorption	absorption	NN
cord-006860-a3b8hyyr	3161	12	and	and	CC
cord-006860-a3b8hyyr	3161	13	elimination	elimination	NN
cord-006860-a3b8hyyr	3161	14	processes	process	NNS
cord-006860-a3b8hyyr	3161	15	of	of	IN
cord-006860-a3b8hyyr	3161	16	these	these	DT
cord-006860-a3b8hyyr	3161	17	types	type	NNS
cord-006860-a3b8hyyr	3161	18	of	of	IN
cord-006860-a3b8hyyr	3161	19	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3161	20	is	be	VBZ
cord-006860-a3b8hyyr	3161	21	necessary	necessary	JJ
cord-006860-a3b8hyyr	3161	22	.	.	.
cord-006860-a3b8hyyr	3162	1	The	the	DT
cord-006860-a3b8hyyr	3162	2	piperazides	piperazide	NNS
cord-006860-a3b8hyyr	3162	3	of	of	IN
cord-006860-a3b8hyyr	3162	4	3-amidinophenylalanine	3-amidinophenylalanine	CD
cord-006860-a3b8hyyr	3162	5	bear	bear	VB
cord-006860-a3b8hyyr	3162	6	the	the	DT
cord-006860-a3b8hyyr	3162	7	possibility	possibility	NN
cord-006860-a3b8hyyr	3162	8	to	to	TO
cord-006860-a3b8hyyr	3162	9	easily	easily	RB
cord-006860-a3b8hyyr	3162	10	introduce	introduce	VB
cord-006860-a3b8hyyr	3162	11	a	a	DT
cord-006860-a3b8hyyr	3162	12	wide	wide	JJ
cord-006860-a3b8hyyr	3162	13	variety	variety	NN
cord-006860-a3b8hyyr	3162	14	of	of	IN
cord-006860-a3b8hyyr	3162	15	substituents	substituent	NNS
cord-006860-a3b8hyyr	3162	16	on	on	IN
cord-006860-a3b8hyyr	3162	17	the	the	DT
cord-006860-a3b8hyyr	3162	18	second	second	JJ
cord-006860-a3b8hyyr	3162	19	nitrogen	nitrogen	NN
cord-006860-a3b8hyyr	3162	20	of	of	IN
cord-006860-a3b8hyyr	3162	21	the	the	DT
cord-006860-a3b8hyyr	3162	22	piperazine	piperazine	NN
cord-006860-a3b8hyyr	3162	23	moiety	moiety	NN
cord-006860-a3b8hyyr	3162	24	.	.	.
cord-006860-a3b8hyyr	3163	1	A	a	DT
cord-006860-a3b8hyyr	3163	2	69-year	69-year	JJ
cord-006860-a3b8hyyr	3163	3	-	-	HYPH
cord-006860-a3b8hyyr	3163	4	old	old	JJ
cord-006860-a3b8hyyr	3163	5	female	female	JJ
cord-006860-a3b8hyyr	3163	6	patient	patient	NN
cord-006860-a3b8hyyr	3163	7	with	with	IN
cord-006860-a3b8hyyr	3163	8	diabetic	diabetic	JJ
cord-006860-a3b8hyyr	3163	9	nephropathy	nephropathy	NN
cord-006860-a3b8hyyr	3163	10	increasingly	increasingly	RB
cord-006860-a3b8hyyr	3163	11	developed	develop	VBD
cord-006860-a3b8hyyr	3163	12	signs	sign	NNS
cord-006860-a3b8hyyr	3163	13	of	of	IN
cord-006860-a3b8hyyr	3163	14	allergisation	allergisation	NN
cord-006860-a3b8hyyr	3163	15	combined	combine	VBN
cord-006860-a3b8hyyr	3163	16	with	with	IN
cord-006860-a3b8hyyr	3163	17	dyspnea	dyspnea	NN
cord-006860-a3b8hyyr	3163	18	,	,	,
cord-006860-a3b8hyyr	3163	19	erythema	erythema	NN
cord-006860-a3b8hyyr	3163	20	,	,	,
cord-006860-a3b8hyyr	3163	21	pruritus	pruritus	NN
cord-006860-a3b8hyyr	3163	22	,	,	,
cord-006860-a3b8hyyr	3163	23	and	and	CC
cord-006860-a3b8hyyr	3163	24	circulatory	circulatory	JJ
cord-006860-a3b8hyyr	3163	25	insufficiency	insufficiency	NN
cord-006860-a3b8hyyr	3163	26	two	two	CD
cord-006860-a3b8hyyr	3163	27	months	month	NNS
cord-006860-a3b8hyyr	3163	28	after	after	IN
cord-006860-a3b8hyyr	3163	29	start	start	NN
cord-006860-a3b8hyyr	3163	30	of	of	IN
cord-006860-a3b8hyyr	3163	31	heparin	heparin	NN
cord-006860-a3b8hyyr	3163	32	-	-	HYPH
cord-006860-a3b8hyyr	3163	33	anticoagulated	anticoagulate	VBN
cord-006860-a3b8hyyr	3163	34	haemodialysis	haemodialysis	NNP
cord-006860-a3b8hyyr	3163	35	und	und	IN
cord-006860-a3b8hyyr	3163	36	initial	initial	JJ
cord-006860-a3b8hyyr	3163	37	surgical	surgical	JJ
cord-006860-a3b8hyyr	3163	38	application	application	NN
cord-006860-a3b8hyyr	3163	39	of	of	IN
cord-006860-a3b8hyyr	3163	40	a	a	DT
cord-006860-a3b8hyyr	3163	41	double	double	JJ
cord-006860-a3b8hyyr	3163	42	lumen	lumen	JJ
cord-006860-a3b8hyyr	3163	43	venous	venous	JJ
cord-006860-a3b8hyyr	3163	44	catheter	catheter	NN
cord-006860-a3b8hyyr	3163	45	.	.	.
cord-006860-a3b8hyyr	3164	1	In	in	IN
cord-006860-a3b8hyyr	3164	2	addition	addition	NN
cord-006860-a3b8hyyr	3164	3	,	,	,
cord-006860-a3b8hyyr	3164	4	growing	grow	VBG
cord-006860-a3b8hyyr	3164	5	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	3164	6	was	be	VBD
cord-006860-a3b8hyyr	3164	7	observed	observe	VBN
cord-006860-a3b8hyyr	3164	8	involving	involve	VBG
cord-006860-a3b8hyyr	3164	9	a	a	DT
cord-006860-a3b8hyyr	3164	10	drop	drop	NN
cord-006860-a3b8hyyr	3164	11	in	in	IN
cord-006860-a3b8hyyr	3164	12	platelets	platelet	NNS
cord-006860-a3b8hyyr	3164	13	by	by	IN
cord-006860-a3b8hyyr	3164	14	50	50	CD
cord-006860-a3b8hyyr	3164	15	%	%	NN
cord-006860-a3b8hyyr	3164	16	,	,	,
cord-006860-a3b8hyyr	3164	17	compared	compare	VBN
cord-006860-a3b8hyyr	3164	18	to	to	IN
cord-006860-a3b8hyyr	3164	19	the	the	DT
cord-006860-a3b8hyyr	3164	20	initial	initial	JJ
cord-006860-a3b8hyyr	3164	21	values	value	NNS
cord-006860-a3b8hyyr	3164	22	.	.	.
cord-006860-a3b8hyyr	3165	1	The	the	DT
cord-006860-a3b8hyyr	3165	2	haemodialytic	haemodialytic	JJ
cord-006860-a3b8hyyr	3165	3	efficiency	efficiency	NN
cord-006860-a3b8hyyr	3165	4	was	be	VBD
cord-006860-a3b8hyyr	3165	5	reduced	reduce	VBN
cord-006860-a3b8hyyr	3165	6	by	by	IN
cord-006860-a3b8hyyr	3165	7	massive	massive	JJ
cord-006860-a3b8hyyr	3165	8	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3165	9	of	of	IN
cord-006860-a3b8hyyr	3165	10	the	the	DT
cord-006860-a3b8hyyr	3165	11	dialyzer	dialyzer	NN
cord-006860-a3b8hyyr	3165	12	and	and	CC
cord-006860-a3b8hyyr	3165	13	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	3165	14	repeated	repeat	VBN
cord-006860-a3b8hyyr	3165	15	interruption	interruption	NN
cord-006860-a3b8hyyr	3165	16	of	of	IN
cord-006860-a3b8hyyr	3165	17	treatment	treatment	NN
cord-006860-a3b8hyyr	3165	18	.	.	.
cord-006860-a3b8hyyr	3166	1	At	at	IN
cord-006860-a3b8hyyr	3166	2	the	the	DT
cord-006860-a3b8hyyr	3166	3	end	end	NN
cord-006860-a3b8hyyr	3166	4	of	of	IN
cord-006860-a3b8hyyr	3166	5	May	May	NNP
cord-006860-a3b8hyyr	3166	6	1995	1995	CD
cord-006860-a3b8hyyr	3166	7	heparin	heparin	NN
cord-006860-a3b8hyyr	3166	8	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3166	9	were	be	VBD
cord-006860-a3b8hyyr	3166	10	detected	detect	VBN
cord-006860-a3b8hyyr	3166	11	and	and	CC
cord-006860-a3b8hyyr	3166	12	the	the	DT
cord-006860-a3b8hyyr	3166	13	HAT	hat	NN
cord-006860-a3b8hyyr	3166	14	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	3166	15	was	be	VBD
cord-006860-a3b8hyyr	3166	16	confirmed	confirm	VBN
cord-006860-a3b8hyyr	3166	17	.	.	.
cord-006860-a3b8hyyr	3167	1	Immediately	immediately	RB
cord-006860-a3b8hyyr	3167	2	afterwards	afterwards	RB
cord-006860-a3b8hyyr	3167	3	,	,	,
cord-006860-a3b8hyyr	3167	4	haemodialysis	haemodialysis	NNP
cord-006860-a3b8hyyr	3167	5	treatment	treatment	NN
cord-006860-a3b8hyyr	3167	6	was	be	VBD
cord-006860-a3b8hyyr	3167	7	continued	continue	VBN
cord-006860-a3b8hyyr	3167	8	,	,	,
cord-006860-a3b8hyyr	3167	9	applying	apply	VBG
cord-006860-a3b8hyyr	3167	10	hirudin	hirudin	RB
cord-006860-a3b8hyyr	3167	11	as	as	IN
cord-006860-a3b8hyyr	3167	12	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3167	13	.	.	.
cord-006860-a3b8hyyr	3168	1	Using	use	VBG
cord-006860-a3b8hyyr	3168	2	steam	steam	NN
cord-006860-a3b8hyyr	3168	3	-	-	HYPH
cord-006860-a3b8hyyr	3168	4	stedlised	stedlise	VBN
cord-006860-a3b8hyyr	3168	5	Haemophan	Haemophan	NNP
cord-006860-a3b8hyyr	3168	6	dialyzers	dialyzer	NNS
cord-006860-a3b8hyyr	3168	7	and	and	CC
cord-006860-a3b8hyyr	3168	8	0.14	0.14	CD
cord-006860-a3b8hyyr	3168	9	mg	mg	NNS
cord-006860-a3b8hyyr	3168	10	/	/	SYM
cord-006860-a3b8hyyr	3168	11	kg	kg	NNP
cord-006860-a3b8hyyr	3168	12	r	r	NN
cord-006860-a3b8hyyr	3168	13	-	-	:
cord-006860-a3b8hyyr	3168	14	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3168	15	(	(	-LRB-
cord-006860-a3b8hyyr	3168	16	Iketon	Iketon	NNP
cord-006860-a3b8hyyr	3168	17	,	,	,
cord-006860-a3b8hyyr	3168	18	Italy	Italy	NNP
cord-006860-a3b8hyyr	3168	19	)	)	-RRB-
cord-006860-a3b8hyyr	3168	20	,	,	,
cord-006860-a3b8hyyr	3168	21	the	the	DT
cord-006860-a3b8hyyr	3168	22	minimum	minimum	JJ
cord-006860-a3b8hyyr	3168	23	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	3168	24	blood	blood	NN
cord-006860-a3b8hyyr	3168	25	level	level	NN
cord-006860-a3b8hyyr	3168	26	of	of	IN
cord-006860-a3b8hyyr	3168	27	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3168	28	(	(	-LRB-
cord-006860-a3b8hyyr	3168	29	0.4	0.4	CD
cord-006860-a3b8hyyr	3168	30	pg	pg	NN
cord-006860-a3b8hyyr	3168	31	/	/	SYM
cord-006860-a3b8hyyr	3168	32	ml	ml	IN
cord-006860-a3b8hyyr	3168	33	whole	whole	JJ
cord-006860-a3b8hyyr	3168	34	blood	blood	NN
cord-006860-a3b8hyyr	3168	35	)	)	-RRB-
cord-006860-a3b8hyyr	3168	36	was	be	VBD
cord-006860-a3b8hyyr	3168	37	reached	reach	VBN
cord-006860-a3b8hyyr	3168	38	.	.	.
cord-006860-a3b8hyyr	3169	1	This	this	DT
cord-006860-a3b8hyyr	3169	2	provided	provide	VBD
cord-006860-a3b8hyyr	3169	3	therapeutically	therapeutically	RB
cord-006860-a3b8hyyr	3169	4	relevant	relevant	JJ
cord-006860-a3b8hyyr	3169	5	blood	blood	NN
cord-006860-a3b8hyyr	3169	6	level	level	NN
cord-006860-a3b8hyyr	3169	7	conditions	condition	NNS
cord-006860-a3b8hyyr	3169	8	during	during	IN
cord-006860-a3b8hyyr	3169	9	a	a	DT
cord-006860-a3b8hyyr	3169	10	4.5h	4.5h	CD
cord-006860-a3b8hyyr	3169	11	haemodialysis	haemodialysis	NNP
cord-006860-a3b8hyyr	3169	12	.	.	.
cord-006860-a3b8hyyr	3170	1	More	More	JJR
cord-006860-a3b8hyyr	3170	2	than	than	IN
cord-006860-a3b8hyyr	3170	3	80	80	CD
cord-006860-a3b8hyyr	3170	4	regular	regular	JJ
cord-006860-a3b8hyyr	3170	5	haemodialyses	haemodialysis	NNS
cord-006860-a3b8hyyr	3170	6	were	be	VBD
cord-006860-a3b8hyyr	3170	7	run	run	VBN
cord-006860-a3b8hyyr	3170	8	without	without	IN
cord-006860-a3b8hyyr	3170	9	problems	problem	NNS
cord-006860-a3b8hyyr	3170	10	.	.	.
cord-006860-a3b8hyyr	3171	1	In	in	IN
cord-006860-a3b8hyyr	3171	2	all	all	DT
cord-006860-a3b8hyyr	3171	3	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3171	4	-	-	HYPH
cord-006860-a3b8hyyr	3171	5	anticoagulated	anticoagulate	VBN
cord-006860-a3b8hyyr	3171	6	haemodialysis	haemodialysis	NNP
cord-006860-a3b8hyyr	3171	7	treatments	treatment	NNS
cord-006860-a3b8hyyr	3171	8	the	the	DT
cord-006860-a3b8hyyr	3171	9	ecarin	ecarin	NNP
cord-006860-a3b8hyyr	3171	10	clotting	clotting	NN
cord-006860-a3b8hyyr	3171	11	time	time	NN
cord-006860-a3b8hyyr	3171	12	was	be	VBD
cord-006860-a3b8hyyr	3171	13	used	use	VBN
cord-006860-a3b8hyyr	3171	14	as	as	IN
cord-006860-a3b8hyyr	3171	15	the	the	DT
cord-006860-a3b8hyyr	3171	16	method	method	NN
cord-006860-a3b8hyyr	3171	17	of	of	IN
cord-006860-a3b8hyyr	3171	18	choice	choice	NN
cord-006860-a3b8hyyr	3171	19	for	for	IN
cord-006860-a3b8hyyr	3171	20	bedside	bedside	NN
cord-006860-a3b8hyyr	3171	21	blood	blood	NN
cord-006860-a3b8hyyr	3171	22	level	level	NN
cord-006860-a3b8hyyr	3171	23	and	and	CC
cord-006860-a3b8hyyr	3171	24	dosage	dosage	NN
cord-006860-a3b8hyyr	3171	25	control	control	NN
cord-006860-a3b8hyyr	3171	26	.	.	.
cord-006860-a3b8hyyr	3172	1	After	after	IN
cord-006860-a3b8hyyr	3172	2	the	the	DT
cord-006860-a3b8hyyr	3172	3	34th	34th	JJ
cord-006860-a3b8hyyr	3172	4	haemodialysis	haemodialysis	NNP
cord-006860-a3b8hyyr	3172	5	,	,	,
cord-006860-a3b8hyyr	3172	6	the	the	DT
cord-006860-a3b8hyyr	3172	7	frequency	frequency	NN
cord-006860-a3b8hyyr	3172	8	was	be	VBD
cord-006860-a3b8hyyr	3172	9	reduced	reduce	VBN
cord-006860-a3b8hyyr	3172	10	from	from	IN
cord-006860-a3b8hyyr	3172	11	3(4	3(4	NNP
cord-006860-a3b8hyyr	3172	12	)	)	-RRB-
cord-006860-a3b8hyyr	3172	13	to	to	IN
cord-006860-a3b8hyyr	3172	14	2	2	CD
cord-006860-a3b8hyyr	3172	15	haemodialyses	haemodialysis	NNS
cord-006860-a3b8hyyr	3172	16	a	a	DT
cord-006860-a3b8hyyr	3172	17	week	week	NN
cord-006860-a3b8hyyr	3172	18	.	.	.
cord-006860-a3b8hyyr	3173	1	Accordingly	accordingly	RB
cord-006860-a3b8hyyr	3173	2	,	,	,
cord-006860-a3b8hyyr	3173	3	the	the	DT
cord-006860-a3b8hyyr	3173	4	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3173	5	dose	dose	NN
cord-006860-a3b8hyyr	3173	6	was	be	VBD
cord-006860-a3b8hyyr	3173	7	increased	increase	VBN
cord-006860-a3b8hyyr	3173	8	to	to	IN
cord-006860-a3b8hyyr	3173	9	0.2	0.2	CD
cord-006860-a3b8hyyr	3173	10	mg	mg	NN
cord-006860-a3b8hyyr	3173	11	/	/	SYM
cord-006860-a3b8hyyr	3173	12	kg	kg	NNP
cord-006860-a3b8hyyr	3173	13	.	.	.
cord-006860-a3b8hyyr	3174	1	The	the	DT
cord-006860-a3b8hyyr	3174	2	creatinine	creatinine	NN
cord-006860-a3b8hyyr	3174	3	clearance	clearance	NN
cord-006860-a3b8hyyr	3174	4	increased	increase	VBD
cord-006860-a3b8hyyr	3174	5	continuously	continuously	RB
cord-006860-a3b8hyyr	3174	6	from	from	IN
cord-006860-a3b8hyyr	3174	7	initially	initially	RB
cord-006860-a3b8hyyr	3174	8	2.6	2.6	CD
cord-006860-a3b8hyyr	3174	9	to	to	IN
cord-006860-a3b8hyyr	3174	10	10.4	10.4	CD
cord-006860-a3b8hyyr	3174	11	ml	ml	NNS
cord-006860-a3b8hyyr	3174	12	/	/	SYM
cord-006860-a3b8hyyr	3174	13	min	min	NN
cord-006860-a3b8hyyr	3174	14	after	after	IN
cord-006860-a3b8hyyr	3174	15	the	the	DT
cord-006860-a3b8hyyr	3174	16	13th	13th	JJ
cord-006860-a3b8hyyr	3174	17	week	week	NN
cord-006860-a3b8hyyr	3174	18	of	of	IN
cord-006860-a3b8hyyr	3174	19	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3174	20	-	-	HYPH
cord-006860-a3b8hyyr	3174	21	anticoagulated	anticoagulate	VBN
cord-006860-a3b8hyyr	3174	22	haemodialysis	haemodialysis	NNP
cord-006860-a3b8hyyr	3174	23	.	.	.
cord-006860-a3b8hyyr	3175	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	3175	2	count	count	NN
cord-006860-a3b8hyyr	3175	3	and	and	CC
cord-006860-a3b8hyyr	3175	4	haemodialytic	haemodialytic	JJ
cord-006860-a3b8hyyr	3175	5	efficiency	efficiency	NN
cord-006860-a3b8hyyr	3175	6	normalized	normalize	VBN
cord-006860-a3b8hyyr	3175	7	.	.	.
cord-006860-a3b8hyyr	3176	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3176	2	could	could	MD
cord-006860-a3b8hyyr	3176	3	demonstrate	demonstrate	VB
cord-006860-a3b8hyyr	3176	4	that	that	IN
cord-006860-a3b8hyyr	3176	5	the	the	DT
cord-006860-a3b8hyyr	3176	6	regular	regular	JJ
cord-006860-a3b8hyyr	3176	7	use	use	NN
cord-006860-a3b8hyyr	3176	8	of	of	IN
cord-006860-a3b8hyyr	3176	9	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3176	10	as	as	IN
cord-006860-a3b8hyyr	3176	11	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3176	12	along	along	IN
cord-006860-a3b8hyyr	3176	13	with	with	IN
cord-006860-a3b8hyyr	3176	14	dialyzers	dialyzer	NNS
cord-006860-a3b8hyyr	3176	15	impermeable	impermeable	JJ
cord-006860-a3b8hyyr	3176	16	to	to	IN
cord-006860-a3b8hyyr	3176	17	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3176	18	enables	enable	VBZ
cord-006860-a3b8hyyr	3176	19	very	very	RB
cord-006860-a3b8hyyr	3176	20	good	good	JJ
cord-006860-a3b8hyyr	3176	21	results	result	NNS
cord-006860-a3b8hyyr	3176	22	in	in	IN
cord-006860-a3b8hyyr	3176	23	haemodialysis	haemodialysis	NNP
cord-006860-a3b8hyyr	3176	24	treatment	treatment	NN
cord-006860-a3b8hyyr	3176	25	in	in	IN
cord-006860-a3b8hyyr	3176	26	heparin	heparin	NN
cord-006860-a3b8hyyr	3176	27	-	-	HYPH
cord-006860-a3b8hyyr	3176	28	associated	associate	VBN
cord-006860-a3b8hyyr	3176	29	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	3176	30	,	,	,
cord-006860-a3b8hyyr	3176	31	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3176	32	is	be	VBZ
cord-006860-a3b8hyyr	3176	33	suited	suit	VBN
cord-006860-a3b8hyyr	3176	34	for	for	IN
cord-006860-a3b8hyyr	3176	35	use	use	NN
cord-006860-a3b8hyyr	3176	36	as	as	IN
cord-006860-a3b8hyyr	3176	37	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3176	38	in	in	IN
cord-006860-a3b8hyyr	3176	39	problem	problem	NN
cord-006860-a3b8hyyr	3176	40	patients	patient	NNS
cord-006860-a3b8hyyr	3176	41	with	with	IN
cord-006860-a3b8hyyr	3176	42	hepadn	hepadn	NNP
cord-006860-a3b8hyyr	3176	43	-	-	HYPH
cord-006860-a3b8hyyr	3176	44	induced	induce	VBN
cord-006860-a3b8hyyr	3176	45	allergy	allergy	NN
cord-006860-a3b8hyyr	3176	46	when	when	WRB
cord-006860-a3b8hyyr	3176	47	combined	combine	VBN
cord-006860-a3b8hyyr	3176	48	with	with	IN
cord-006860-a3b8hyyr	3176	49	a	a	DT
cord-006860-a3b8hyyr	3176	50	drug	drug	NN
cord-006860-a3b8hyyr	3176	51	monitoring	monitoring	NN
cord-006860-a3b8hyyr	3176	52	method	method	NN
cord-006860-a3b8hyyr	3176	53	fit	fit	JJ
cord-006860-a3b8hyyr	3176	54	for	for	IN
cord-006860-a3b8hyyr	3176	55	bedside	bedside	NN
cord-006860-a3b8hyyr	3176	56	use	use	NN
cord-006860-a3b8hyyr	3176	57	.	.	.
cord-006860-a3b8hyyr	3177	1	Capillary	capillary	JJ
cord-006860-a3b8hyyr	3177	2	electrophoresis	electrophoresis	NN
cord-006860-a3b8hyyr	3177	3	methods	method	NNS
cord-006860-a3b8hyyr	3177	4	provide	provide	VBP
cord-006860-a3b8hyyr	3177	5	a	a	DT
cord-006860-a3b8hyyr	3177	6	fast	fast	JJ
cord-006860-a3b8hyyr	3177	7	measurement	measurement	NN
cord-006860-a3b8hyyr	3177	8	of	of	IN
cord-006860-a3b8hyyr	3177	9	proteins	protein	NNS
cord-006860-a3b8hyyr	3177	10	.	.	.
cord-006860-a3b8hyyr	3178	1	Thus	thus	RB
cord-006860-a3b8hyyr	3178	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	3178	3	developed	develop	VBD
cord-006860-a3b8hyyr	3178	4	for	for	IN
cord-006860-a3b8hyyr	3178	5	pharmacokinetic	pharmacokinetic	JJ
cord-006860-a3b8hyyr	3178	6	measurements	measurement	NNS
cord-006860-a3b8hyyr	3178	7	of	of	IN
cord-006860-a3b8hyyr	3178	8	r	r	NN
cord-006860-a3b8hyyr	3178	9	-	-	HYPH
cord-006860-a3b8hyyr	3178	10	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3178	11	and	and	CC
cord-006860-a3b8hyyr	3178	12	peg	peg	NN
cord-006860-a3b8hyyr	3178	13	-	-	HYPH
cord-006860-a3b8hyyr	3178	14	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3178	15	capillary	capillary	JJ
cord-006860-a3b8hyyr	3178	16	electrophoresis	electrophoresis	NN
cord-006860-a3b8hyyr	3178	17	methods	method	NNS
cord-006860-a3b8hyyr	3178	18	.	.	.
cord-006860-a3b8hyyr	3179	1	For	for	IN
cord-006860-a3b8hyyr	3179	2	the	the	DT
cord-006860-a3b8hyyr	3179	3	measurement	measurement	NN
cord-006860-a3b8hyyr	3179	4	of	of	IN
cord-006860-a3b8hyyr	3179	5	r	r	NN
cord-006860-a3b8hyyr	3179	6	-	-	:
cord-006860-a3b8hyyr	3179	7	hirudin	hirudin	RB
cord-006860-a3b8hyyr	3179	8	we	-PRON-	PRP
cord-006860-a3b8hyyr	3179	9	used	use	VBD
cord-006860-a3b8hyyr	3179	10	fused	fuse	VBN
cord-006860-a3b8hyyr	3179	11	silica	silica	NN
cord-006860-a3b8hyyr	3179	12	capillary	capillary	NN
cord-006860-a3b8hyyr	3179	13	and	and	CC
cord-006860-a3b8hyyr	3179	14	a	a	DT
cord-006860-a3b8hyyr	3179	15	borate	borate	NN
cord-006860-a3b8hyyr	3179	16	buffer	buffer	NN
cord-006860-a3b8hyyr	3179	17	.	.	.
cord-006860-a3b8hyyr	3180	1	This	this	DT
cord-006860-a3b8hyyr	3180	2	buffer	buffer	NN
cord-006860-a3b8hyyr	3180	3	was	be	VBD
cord-006860-a3b8hyyr	3180	4	used	use	VBN
cord-006860-a3b8hyyr	3180	5	to	to	TO
cord-006860-a3b8hyyr	3180	6	detect	detect	VB
cord-006860-a3b8hyyr	3180	7	r	r	NN
cord-006860-a3b8hyyr	3180	8	-	-	HYPH
cord-006860-a3b8hyyr	3180	9	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3180	10	,	,	,
cord-006860-a3b8hyyr	3180	11	but	but	CC
cord-006860-a3b8hyyr	3180	12	could	could	MD
cord-006860-a3b8hyyr	3180	13	not	not	RB
cord-006860-a3b8hyyr	3180	14	be	be	VB
cord-006860-a3b8hyyr	3180	15	used	use	VBN
cord-006860-a3b8hyyr	3180	16	to	to	TO
cord-006860-a3b8hyyr	3180	17	measure	measure	VB
cord-006860-a3b8hyyr	3180	18	PEG	peg	NN
cord-006860-a3b8hyyr	3180	19	-	-	HYPH
cord-006860-a3b8hyyr	3180	20	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3180	21	.	.	.
cord-006860-a3b8hyyr	3181	1	For	for	IN
cord-006860-a3b8hyyr	3181	2	simultaneous	simultaneous	JJ
cord-006860-a3b8hyyr	3181	3	measurement	measurement	NN
cord-006860-a3b8hyyr	3181	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	3181	5	used	use	VBD
cord-006860-a3b8hyyr	3181	6	a	a	DT
cord-006860-a3b8hyyr	3181	7	neutral	neutral	JJ
cord-006860-a3b8hyyr	3181	8	capillary	capillary	NN
cord-006860-a3b8hyyr	3181	9	to	to	TO
cord-006860-a3b8hyyr	3181	10	prevent	prevent	VB
cord-006860-a3b8hyyr	3181	11	protein	protein	NN
cord-006860-a3b8hyyr	3181	12	absorption	absorption	NN
cord-006860-a3b8hyyr	3181	13	to	to	IN
cord-006860-a3b8hyyr	3181	14	the	the	DT
cord-006860-a3b8hyyr	3181	15	capillary	capillary	JJ
cord-006860-a3b8hyyr	3181	16	wall	wall	NN
cord-006860-a3b8hyyr	3181	17	.	.	.
cord-006860-a3b8hyyr	3182	1	The	the	DT
cord-006860-a3b8hyyr	3182	2	buffer	buffer	NN
cord-006860-a3b8hyyr	3182	3	was	be	VBD
cord-006860-a3b8hyyr	3182	4	a	a	DT
cord-006860-a3b8hyyr	3182	5	20	20	CD
cord-006860-a3b8hyyr	3182	6	mM	mm	NN
cord-006860-a3b8hyyr	3182	7	tricine	tricine	NN
cord-006860-a3b8hyyr	3182	8	buffer	buffer	NN
cord-006860-a3b8hyyr	3182	9	(	(	-LRB-
cord-006860-a3b8hyyr	3182	10	pH	ph	NN
cord-006860-a3b8hyyr	3182	11	=	=	SYM
cord-006860-a3b8hyyr	3182	12	8.0	8.0	CD
cord-006860-a3b8hyyr	3182	13	field	field	NN
cord-006860-a3b8hyyr	3182	14	strength	strength	NN
cord-006860-a3b8hyyr	3182	15	500	500	CD
cord-006860-a3b8hyyr	3182	16	V	v	NN
cord-006860-a3b8hyyr	3182	17	/	/	SYM
cord-006860-a3b8hyyr	3182	18	cm	cm	NN
cord-006860-a3b8hyyr	3182	19	)	)	-RRB-
cord-006860-a3b8hyyr	3182	20	.	.	.
cord-006860-a3b8hyyr	3183	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	3183	2	resolved	resolve	VBD
cord-006860-a3b8hyyr	3183	3	r	r	NN
cord-006860-a3b8hyyr	3183	4	-	-	:
cord-006860-a3b8hyyr	3183	5	hirudin	hirudin	RB
cord-006860-a3b8hyyr	3183	6	from	from	IN
cord-006860-a3b8hyyr	3183	7	peg	peg	NN
cord-006860-a3b8hyyr	3183	8	-	-	HYPH
cord-006860-a3b8hyyr	3183	9	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3183	10	at	at	IN
cord-006860-a3b8hyyr	3183	11	214	214	CD
cord-006860-a3b8hyyr	3183	12	nm	nm	CD
cord-006860-a3b8hyyr	3183	13	using	use	VBG
cord-006860-a3b8hyyr	3183	14	reverse	reverse	JJ
cord-006860-a3b8hyyr	3183	15	polarity	polarity	NN
cord-006860-a3b8hyyr	3183	16	.	.	.
cord-006860-a3b8hyyr	3184	1	A	a	DT
cord-006860-a3b8hyyr	3184	2	linear	linear	JJ
cord-006860-a3b8hyyr	3184	3	correlation	correlation	NN
cord-006860-a3b8hyyr	3184	4	between	between	IN
cord-006860-a3b8hyyr	3184	5	the	the	DT
cord-006860-a3b8hyyr	3184	6	peak	peak	NN
cord-006860-a3b8hyyr	3184	7	area	area	NN
cord-006860-a3b8hyyr	3184	8	and	and	CC
cord-006860-a3b8hyyr	3184	9	the	the	DT
cord-006860-a3b8hyyr	3184	10	concentration	concentration	NN
cord-006860-a3b8hyyr	3184	11	was	be	VBD
cord-006860-a3b8hyyr	3184	12	found	find	VBN
cord-006860-a3b8hyyr	3184	13	between	between	IN
cord-006860-a3b8hyyr	3184	14	80	80	CD
cord-006860-a3b8hyyr	3184	15	pgtml	pgtml	NNS
cord-006860-a3b8hyyr	3184	16	and	and	CC
cord-006860-a3b8hyyr	3184	17	10	10	CD
cord-006860-a3b8hyyr	3184	18	mg	mg	NNP
cord-006860-a3b8hyyr	3184	19	/	/	SYM
cord-006860-a3b8hyyr	3184	20	ml	ml	NN
cord-006860-a3b8hyyr	3184	21	for	for	IN
cord-006860-a3b8hyyr	3184	22	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3184	23	(	(	-LRB-
cord-006860-a3b8hyyr	3184	24	r	r	NN
cord-006860-a3b8hyyr	3184	25	2	2	CD
cord-006860-a3b8hyyr	3184	26	=	=	SYM
cord-006860-a3b8hyyr	3184	27	0.99	0.99	CD
cord-006860-a3b8hyyr	3184	28	)	)	-RRB-
cord-006860-a3b8hyyr	3184	29	and	and	CC
cord-006860-a3b8hyyr	3184	30	between	between	IN
cord-006860-a3b8hyyr	3184	31	2,5	2,5	CD
cord-006860-a3b8hyyr	3184	32	and	and	CC
cord-006860-a3b8hyyr	3184	33	10	10	CD
cord-006860-a3b8hyyr	3184	34	mg	mg	NNP
cord-006860-a3b8hyyr	3184	35	/	/	SYM
cord-006860-a3b8hyyr	3184	36	ml	ml	NN
cord-006860-a3b8hyyr	3184	37	for	for	IN
cord-006860-a3b8hyyr	3184	38	peg	peg	NN
cord-006860-a3b8hyyr	3184	39	-	-	HYPH
cord-006860-a3b8hyyr	3184	40	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3184	41	(	(	-LRB-
cord-006860-a3b8hyyr	3184	42	r2=	r2=	NNP
cord-006860-a3b8hyyr	3184	43	0.99	0.99	CD
cord-006860-a3b8hyyr	3184	44	)	)	-RRB-
cord-006860-a3b8hyyr	3184	45	was	be	VBD
cord-006860-a3b8hyyr	3184	46	found	find	VBN
cord-006860-a3b8hyyr	3184	47	By	by	IN
cord-006860-a3b8hyyr	3184	48	coinspiking	coinspike	VBG
cord-006860-a3b8hyyr	3184	49	of	of	IN
cord-006860-a3b8hyyr	3184	50	human	human	JJ
cord-006860-a3b8hyyr	3184	51	plasma	plasma	NN
cord-006860-a3b8hyyr	3184	52	and	and	CC
cord-006860-a3b8hyyr	3184	53	urine	urine	NN
cord-006860-a3b8hyyr	3184	54	with	with	IN
cord-006860-a3b8hyyr	3184	55	r	r	NN
cord-006860-a3b8hyyr	3184	56	-	-	HYPH
cord-006860-a3b8hyyr	3184	57	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3184	58	and	and	CC
cord-006860-a3b8hyyr	3184	59	peghirudin	peghirudin	NNP
cord-006860-a3b8hyyr	3184	60	the	the	DT
cord-006860-a3b8hyyr	3184	61	two	two	CD
cord-006860-a3b8hyyr	3184	62	proteins	protein	NNS
cord-006860-a3b8hyyr	3184	63	were	be	VBD
cord-006860-a3b8hyyr	3184	64	completely	completely	RB
cord-006860-a3b8hyyr	3184	65	resolved	resolve	VBN
cord-006860-a3b8hyyr	3184	66	.	.	.
cord-006860-a3b8hyyr	3185	1	A	a	DT
cord-006860-a3b8hyyr	3185	2	linear	linear	JJ
cord-006860-a3b8hyyr	3185	3	correlation	correlation	NN
cord-006860-a3b8hyyr	3185	4	between	between	IN
cord-006860-a3b8hyyr	3185	5	the	the	DT
cord-006860-a3b8hyyr	3185	6	peak	peak	NN
cord-006860-a3b8hyyr	3185	7	area	area	NN
cord-006860-a3b8hyyr	3185	8	and	and	CC
cord-006860-a3b8hyyr	3185	9	the	the	DT
cord-006860-a3b8hyyr	3185	10	concentration	concentration	NN
cord-006860-a3b8hyyr	3185	11	was	be	VBD
cord-006860-a3b8hyyr	3185	12	found	find	VBN
cord-006860-a3b8hyyr	3185	13	.	.	.
cord-006860-a3b8hyyr	3186	1	The	the	DT
cord-006860-a3b8hyyr	3186	2	method	method	NN
cord-006860-a3b8hyyr	3186	3	separates	separate	VBZ
cord-006860-a3b8hyyr	3186	4	r	r	NN
cord-006860-a3b8hyyr	3186	5	-	-	:
cord-006860-a3b8hyyr	3186	6	hirudin	hirudin	RB
cord-006860-a3b8hyyr	3186	7	from	from	IN
cord-006860-a3b8hyyr	3186	8	peg	peg	NN
cord-006860-a3b8hyyr	3186	9	-	-	HYPH
cord-006860-a3b8hyyr	3186	10	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3186	11	and	and	CC
cord-006860-a3b8hyyr	3186	12	may	may	MD
cord-006860-a3b8hyyr	3186	13	be	be	VB
cord-006860-a3b8hyyr	3186	14	applied	apply	VBN
cord-006860-a3b8hyyr	3186	15	to	to	IN
cord-006860-a3b8hyyr	3186	16	biological	biological	JJ
cord-006860-a3b8hyyr	3186	17	systems	system	NNS
cord-006860-a3b8hyyr	3186	18	to	to	TO
cord-006860-a3b8hyyr	3186	19	measure	measure	VB
cord-006860-a3b8hyyr	3186	20	the	the	DT
cord-006860-a3b8hyyr	3186	21	concentration	concentration	NN
cord-006860-a3b8hyyr	3186	22	of	of	IN
cord-006860-a3b8hyyr	3186	23	r	r	NN
cord-006860-a3b8hyyr	3186	24	-	-	:
cord-006860-a3b8hyyr	3186	25	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3186	26	.	.	.
cord-006860-a3b8hyyr	3187	1	Triabin	Triabin	NNP
cord-006860-a3b8hyyr	3187	2	is	be	VBZ
cord-006860-a3b8hyyr	3187	3	a	a	DT
cord-006860-a3b8hyyr	3187	4	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3187	5	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3187	6	from	from	IN
cord-006860-a3b8hyyr	3187	7	the	the	DT
cord-006860-a3b8hyyr	3187	8	saliva	saliva	NN
cord-006860-a3b8hyyr	3187	9	ofT.	ofT.	VBN
cord-006860-a3b8hyyr	3187	10	pallidipennis	pallidipenni	NNS
cord-006860-a3b8hyyr	3187	11	structurally	structurally	RB
cord-006860-a3b8hyyr	3187	12	unrelated	unrelated	JJ
cord-006860-a3b8hyyr	3187	13	to	to	IN
cord-006860-a3b8hyyr	3187	14	any	any	DT
cord-006860-a3b8hyyr	3187	15	protease	protease	NN
cord-006860-a3b8hyyr	3187	16	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3187	17	known	know	VBN
cord-006860-a3b8hyyr	3187	18	and	and	CC
cord-006860-a3b8hyyr	3187	19	which	which	WDT
cord-006860-a3b8hyyr	3187	20	probably	probably	RB
cord-006860-a3b8hyyr	3187	21	functions	function	VBZ
cord-006860-a3b8hyyr	3187	22	by	by	IN
cord-006860-a3b8hyyr	3187	23	an	an	DT
cord-006860-a3b8hyyr	3187	24	interaction	interaction	NN
cord-006860-a3b8hyyr	3187	25	with	with	IN
cord-006860-a3b8hyyr	3187	26	the	the	DT
cord-006860-a3b8hyyr	3187	27	anionbinding	anionbinde	VBG
cord-006860-a3b8hyyr	3187	28	exosite	exosite	NNP
cord-006860-a3b8hyyr	3187	29	of	of	IN
cord-006860-a3b8hyyr	3187	30	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3187	31	.	.	.
cord-006860-a3b8hyyr	3188	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3188	2	used	use	VBD
cord-006860-a3b8hyyr	3188	3	Sf9	sf9	NN
cord-006860-a3b8hyyr	3188	4	insect	insect	NN
cord-006860-a3b8hyyr	3188	5	cells	cell	NNS
cord-006860-a3b8hyyr	3188	6	infected	infect	VBN
cord-006860-a3b8hyyr	3188	7	with	with	IN
cord-006860-a3b8hyyr	3188	8	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	3188	9	Baculovirus	Baculovirus	NNP
cord-006860-a3b8hyyr	3188	10	to	to	TO
cord-006860-a3b8hyyr	3188	11	produce	produce	VB
cord-006860-a3b8hyyr	3188	12	sufficient	sufficient	JJ
cord-006860-a3b8hyyr	3188	13	triabin	triabin	NN
cord-006860-a3b8hyyr	3188	14	for	for	IN
cord-006860-a3b8hyyr	3188	15	a	a	DT
cord-006860-a3b8hyyr	3188	16	detailed	detailed	JJ
cord-006860-a3b8hyyr	3188	17	biochemical	biochemical	JJ
cord-006860-a3b8hyyr	3188	18	characterization	characterization	NN
cord-006860-a3b8hyyr	3188	19	.	.	.
cord-006860-a3b8hyyr	3189	1	The	the	DT
cord-006860-a3b8hyyr	3189	2	activity	activity	NN
cord-006860-a3b8hyyr	3189	3	of	of	IN
cord-006860-a3b8hyyr	3189	4	the	the	DT
cord-006860-a3b8hyyr	3189	5	protein	protein	NN
cord-006860-a3b8hyyr	3189	6	purified	purify	VBN
cord-006860-a3b8hyyr	3189	7	from	from	IN
cord-006860-a3b8hyyr	3189	8	cell	cell	NN
cord-006860-a3b8hyyr	3189	9	lysates	lysate	NNS
cord-006860-a3b8hyyr	3189	10	was	be	VBD
cord-006860-a3b8hyyr	3189	11	assessed	assess	VBN
cord-006860-a3b8hyyr	3189	12	in	in	IN
cord-006860-a3b8hyyr	3189	13	a	a	DT
cord-006860-a3b8hyyr	3189	14	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3189	15	clotting	clotting	NN
cord-006860-a3b8hyyr	3189	16	assay	assay	NN
cord-006860-a3b8hyyr	3189	17	and	and	CC
cord-006860-a3b8hyyr	3189	18	was	be	VBD
cord-006860-a3b8hyyr	3189	19	found	find	VBN
cord-006860-a3b8hyyr	3189	20	to	to	TO
cord-006860-a3b8hyyr	3189	21	be	be	VB
cord-006860-a3b8hyyr	3189	22	similar	similar	JJ
cord-006860-a3b8hyyr	3189	23	to	to	IN
cord-006860-a3b8hyyr	3189	24	that	that	DT
cord-006860-a3b8hyyr	3189	25	of	of	IN
cord-006860-a3b8hyyr	3189	26	the	the	DT
cord-006860-a3b8hyyr	3189	27	natural	natural	JJ
cord-006860-a3b8hyyr	3189	28	protein	protein	NN
cord-006860-a3b8hyyr	3189	29	.	.	.
cord-006860-a3b8hyyr	3190	1	A	a	DT
cord-006860-a3b8hyyr	3190	2	4-fold	4-fold	CD
cord-006860-a3b8hyyr	3190	3	prolongation	prolongation	NN
cord-006860-a3b8hyyr	3190	4	of	of	IN
cord-006860-a3b8hyyr	3190	5	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3190	6	-	-	HYPH
cord-006860-a3b8hyyr	3190	7	clotting	clot	VBG
cord-006860-a3b8hyyr	3190	8	time	time	NN
cord-006860-a3b8hyyr	3190	9	and	and	CC
cord-006860-a3b8hyyr	3190	10	APTT	APTT	NNP
cord-006860-a3b8hyyr	3190	11	was	be	VBD
cord-006860-a3b8hyyr	3190	12	achieved	achieve	VBN
cord-006860-a3b8hyyr	3190	13	with	with	IN
cord-006860-a3b8hyyr	3190	14	22	22	CD
cord-006860-a3b8hyyr	3190	15	nM	nm	NN
cord-006860-a3b8hyyr	3190	16	and	and	CC
cord-006860-a3b8hyyr	3190	17	600	600	CD
cord-006860-a3b8hyyr	3190	18	nM	nM	NNP
cord-006860-a3b8hyyr	3190	19	triabin	triabin	NNP
cord-006860-a3b8hyyr	3190	20	,	,	,
cord-006860-a3b8hyyr	3190	21	respectively	respectively	RB
cord-006860-a3b8hyyr	3190	22	.	.	.
cord-006860-a3b8hyyr	3191	1	A	a	DT
cord-006860-a3b8hyyr	3191	2	kinetic	kinetic	JJ
cord-006860-a3b8hyyr	3191	3	analysis	analysis	NN
cord-006860-a3b8hyyr	3191	4	of	of	IN
cord-006860-a3b8hyyr	3191	5	the	the	DT
cord-006860-a3b8hyyr	3191	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3191	7	-	-	HYPH
cord-006860-a3b8hyyr	3191	8	catalyzed	catalyze	VBN
cord-006860-a3b8hyyr	3191	9	fibrinopeptide	fibrinopeptide	NN
cord-006860-a3b8hyyr	3192	1	A	a	DT
cord-006860-a3b8hyyr	3192	2	release	release	NN
cord-006860-a3b8hyyr	3192	3	from	from	IN
cord-006860-a3b8hyyr	3192	4	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3192	5	showed	show	VBD
cord-006860-a3b8hyyr	3192	6	that	that	IN
cord-006860-a3b8hyyr	3192	7	triabin	triabin	NNP
cord-006860-a3b8hyyr	3192	8	is	be	VBZ
cord-006860-a3b8hyyr	3192	9	a	a	DT
cord-006860-a3b8hyyr	3192	10	tight	tight	RB
cord-006860-a3b8hyyr	3192	11	-	-	HYPH
cord-006860-a3b8hyyr	3192	12	binding	bind	VBG
cord-006860-a3b8hyyr	3192	13	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3192	14	.	.	.
cord-006860-a3b8hyyr	3193	1	Using	use	VBG
cord-006860-a3b8hyyr	3193	2	the	the	DT
cord-006860-a3b8hyyr	3193	3	graphical	graphical	JJ
cord-006860-a3b8hyyr	3193	4	method	method	NN
cord-006860-a3b8hyyr	3193	5	of	of	IN
cord-006860-a3b8hyyr	3193	6	Dixon	Dixon	NNP
cord-006860-a3b8hyyr	3193	7	,	,	,
cord-006860-a3b8hyyr	3193	8	the	the	DT
cord-006860-a3b8hyyr	3193	9	Ki	Ki	NNP
cord-006860-a3b8hyyr	3193	10	was	be	VBD
cord-006860-a3b8hyyr	3193	11	determined	determine	VBN
cord-006860-a3b8hyyr	3193	12	to	to	TO
cord-006860-a3b8hyyr	3193	13	be	be	VB
cord-006860-a3b8hyyr	3193	14	3	3	CD
cord-006860-a3b8hyyr	3193	15	pM.	pm.	JJ
cord-006860-a3b8hyyr	3193	16	Introduction	introduction	NN
cord-006860-a3b8hyyr	3193	17	:	:	:
cord-006860-a3b8hyyr	3193	18	Thrombocytopenia	Thrombocytopenia	NNP
cord-006860-a3b8hyyr	3193	19	is	be	VBZ
cord-006860-a3b8hyyr	3193	20	a	a	DT
cord-006860-a3b8hyyr	3193	21	common	common	JJ
cord-006860-a3b8hyyr	3193	22	adverse	adverse	JJ
cord-006860-a3b8hyyr	3193	23	effect	effect	NN
cord-006860-a3b8hyyr	3193	24	of	of	IN
cord-006860-a3b8hyyr	3193	25	heparin	heparin	NN
cord-006860-a3b8hyyr	3193	26	therapy	therapy	NN
cord-006860-a3b8hyyr	3193	27	,	,	,
cord-006860-a3b8hyyr	3193	28	in	in	IN
cord-006860-a3b8hyyr	3193	29	type	type	NN
cord-006860-a3b8hyyr	3193	30	II	II	NNP
cord-006860-a3b8hyyr	3193	31	HIT	hit	NN
cord-006860-a3b8hyyr	3193	32	platelet	platelet	NN
cord-006860-a3b8hyyr	3193	33	decrease	decrease	NN
cord-006860-a3b8hyyr	3193	34	induces	induce	VBZ
cord-006860-a3b8hyyr	3193	35	severe	severe	JJ
cord-006860-a3b8hyyr	3193	36	complications	complication	NNS
cord-006860-a3b8hyyr	3193	37	.	.	.
cord-006860-a3b8hyyr	3194	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3194	2	here	here	RB
cord-006860-a3b8hyyr	3194	3	present	present	VBP
cord-006860-a3b8hyyr	3194	4	two	two	CD
cord-006860-a3b8hyyr	3194	5	special	special	JJ
cord-006860-a3b8hyyr	3194	6	cases	case	NNS
cord-006860-a3b8hyyr	3194	7	of	of	IN
cord-006860-a3b8hyyr	3194	8	type	type	NN
cord-006860-a3b8hyyr	3194	9	II	II	NNP
cord-006860-a3b8hyyr	3194	10	HIT	HIT	NNP
cord-006860-a3b8hyyr	3194	11	.	.	.
cord-006860-a3b8hyyr	3195	1	Case	case	NN
cord-006860-a3b8hyyr	3195	2	report	report	VB
cord-006860-a3b8hyyr	3195	3	I	-PRON-	PRP
cord-006860-a3b8hyyr	3195	4	:	:	:
cord-006860-a3b8hyyr	3196	1	A	a	DT
cord-006860-a3b8hyyr	3196	2	66	66	CD
cord-006860-a3b8hyyr	3196	3	year	year	NN
cord-006860-a3b8hyyr	3196	4	old	old	JJ
cord-006860-a3b8hyyr	3196	5	male	male	JJ
cord-006860-a3b8hyyr	3196	6	patient	patient	NN
cord-006860-a3b8hyyr	3196	7	with	with	IN
cord-006860-a3b8hyyr	3196	8	DVT	DVT	NNP
cord-006860-a3b8hyyr	3196	9	of	of	IN
cord-006860-a3b8hyyr	3196	10	the	the	DT
cord-006860-a3b8hyyr	3196	11	left	left	JJ
cord-006860-a3b8hyyr	3196	12	leg	leg	NN
cord-006860-a3b8hyyr	3196	13	was	be	VBD
cord-006860-a3b8hyyr	3196	14	treated	treat	VBN
cord-006860-a3b8hyyr	3196	15	with	with	IN
cord-006860-a3b8hyyr	3196	16	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	3196	17	doses	dose	NNS
cord-006860-a3b8hyyr	3196	18	of	of	IN
cord-006860-a3b8hyyr	3196	19	heparin	heparin	NN
cord-006860-a3b8hyyr	3196	20	.	.	.
cord-006860-a3b8hyyr	3197	1	From	from	IN
cord-006860-a3b8hyyr	3197	2	the	the	DT
cord-006860-a3b8hyyr	3197	3	first	first	JJ
cord-006860-a3b8hyyr	3197	4	to	to	IN
cord-006860-a3b8hyyr	3197	5	the	the	DT
cord-006860-a3b8hyyr	3197	6	12th	12th	JJ
cord-006860-a3b8hyyr	3197	7	day	day	NN
cord-006860-a3b8hyyr	3197	8	of	of	IN
cord-006860-a3b8hyyr	3197	9	therapy	therapy	NN
cord-006860-a3b8hyyr	3197	10	,	,	,
cord-006860-a3b8hyyr	3197	11	platelet	platelet	NN
cord-006860-a3b8hyyr	3197	12	count	count	NN
cord-006860-a3b8hyyr	3197	13	decreased	decrease	VBD
cord-006860-a3b8hyyr	3197	14	from	from	IN
cord-006860-a3b8hyyr	3197	15	122000	122000	CD
cord-006860-a3b8hyyr	3197	16	to	to	IN
cord-006860-a3b8hyyr	3197	17	54000	54000	CD
cord-006860-a3b8hyyr	3197	18	/	/	SYM
cord-006860-a3b8hyyr	3197	19	ui	ui	NNP
cord-006860-a3b8hyyr	3197	20	.	.	.
cord-006860-a3b8hyyr	3198	1	HIT	HIT	NNP
cord-006860-a3b8hyyr	3198	2	was	be	VBD
cord-006860-a3b8hyyr	3198	3	confirmed	confirm	VBN
cord-006860-a3b8hyyr	3198	4	by	by	IN
cord-006860-a3b8hyyr	3198	5	HIPA	HIPA	NNP
cord-006860-a3b8hyyr	3198	6	-	-	HYPH
cord-006860-a3b8hyyr	3198	7	test	test	NN
cord-006860-a3b8hyyr	3198	8	,	,	,
cord-006860-a3b8hyyr	3198	9	heparin	heparin	JJ
cord-006860-a3b8hyyr	3198	10	therapy	therapy	NN
cord-006860-a3b8hyyr	3198	11	was	be	VBD
cord-006860-a3b8hyyr	3198	12	s	s	NNS
cord-006860-a3b8hyyr	3198	13	~	~	SYM
cord-006860-a3b8hyyr	3198	14	opped	opped	NNP
cord-006860-a3b8hyyr	3198	15	and	and	CC
cord-006860-a3b8hyyr	3198	16	treatment	treatment	NN
cord-006860-a3b8hyyr	3198	17	with	with	IN
cord-006860-a3b8hyyr	3198	18	the	the	DT
cord-006860-a3b8hyyr	3198	19	heparinoid	heparinoid	NNP
cord-006860-a3b8hyyr	3199	1	Orgaran	Orgaran	NNP
cord-006860-a3b8hyyr	3199	2	n	n	NNP
cord-006860-a3b8hyyr	3199	3	was	be	VBD
cord-006860-a3b8hyyr	3199	4	started	start	VBN
cord-006860-a3b8hyyr	3199	5	.	.	.
cord-006860-a3b8hyyr	3200	1	During	during	IN
cord-006860-a3b8hyyr	3200	2	the	the	DT
cord-006860-a3b8hyyr	3200	3	following	follow	VBG
cord-006860-a3b8hyyr	3200	4	days	day	NNS
cord-006860-a3b8hyyr	3200	5	,	,	,
cord-006860-a3b8hyyr	3200	6	arterial	arterial	JJ
cord-006860-a3b8hyyr	3200	7	thromboses	thrombose	NNS
cord-006860-a3b8hyyr	3200	8	in	in	IN
cord-006860-a3b8hyyr	3200	9	the	the	DT
cord-006860-a3b8hyyr	3200	10	right	right	JJ
cord-006860-a3b8hyyr	3200	11	A.	a.	NN
cord-006860-a3b8hyyr	3200	12	femoralis	femoralis	NNP
cord-006860-a3b8hyyr	3200	13	occurred	occur	VBD
cord-006860-a3b8hyyr	3200	14	.	.	.
cord-006860-a3b8hyyr	3201	1	Several	several	JJ
cord-006860-a3b8hyyr	3201	2	thrombe	thrombe	NN
cord-006860-a3b8hyyr	3201	3	~	~	NFP
cord-006860-a3b8hyyr	3201	4	tomies	tomie	NNS
cord-006860-a3b8hyyr	3201	5	were	be	VBD
cord-006860-a3b8hyyr	3201	6	not	not	RB
cord-006860-a3b8hyyr	3201	7	successful	successful	JJ
cord-006860-a3b8hyyr	3201	8	and	and	CC
cord-006860-a3b8hyyr	3202	1	although	although	IN
cord-006860-a3b8hyyr	3202	2	Orgaran	Orgaran	NNP
cord-006860-a3b8hyyr	3202	3	~	~	NFP
cord-006860-a3b8hyyr	3202	4	"	"	''
cord-006860-a3b8hyyr	3202	5	was	be	VBD
cord-006860-a3b8hyyr	3202	6	stopped	stop	VBN
cord-006860-a3b8hyyr	3202	7	because	because	IN
cord-006860-a3b8hyyr	3202	8	of	of	IN
cord-006860-a3b8hyyr	3202	9	suspected	suspect	VBN
cord-006860-a3b8hyyr	3202	10	crossreactivity	crossreactivity	NN
cord-006860-a3b8hyyr	3202	11	,	,	,
cord-006860-a3b8hyyr	3202	12	amputation	amputation	NN
cord-006860-a3b8hyyr	3202	13	of	of	IN
cord-006860-a3b8hyyr	3202	14	the	the	DT
cord-006860-a3b8hyyr	3202	15	right	right	JJ
cord-006860-a3b8hyyr	3202	16	leg	leg	NN
cord-006860-a3b8hyyr	3202	17	could	could	MD
cord-006860-a3b8hyyr	3202	18	not	not	RB
cord-006860-a3b8hyyr	3202	19	be	be	VB
cord-006860-a3b8hyyr	3202	20	avoided	avoid	VBN
cord-006860-a3b8hyyr	3202	21	.	.	.
cord-006860-a3b8hyyr	3203	1	During	during	IN
cord-006860-a3b8hyyr	3203	2	the	the	DT
cord-006860-a3b8hyyr	3203	3	following	follow	VBG
cord-006860-a3b8hyyr	3203	4	days	day	NNS
cord-006860-a3b8hyyr	3203	5	under	under	IN
cord-006860-a3b8hyyr	3203	6	Hirudin	hirudin	NN
cord-006860-a3b8hyyr	3203	7	-	-	HYPH
cord-006860-a3b8hyyr	3203	8	treatment	treatment	NN
cord-006860-a3b8hyyr	3203	9	platelet	platelet	NN
cord-006860-a3b8hyyr	3203	10	count	count	NN
cord-006860-a3b8hyyr	3203	11	normalized	normalize	VBD
cord-006860-a3b8hyyr	3203	12	and	and	CC
cord-006860-a3b8hyyr	3203	13	no	no	DT
cord-006860-a3b8hyyr	3203	14	further	further	JJ
cord-006860-a3b8hyyr	3203	15	complications	complication	NNS
cord-006860-a3b8hyyr	3203	16	occurred	occur	VBD
cord-006860-a3b8hyyr	3203	17	.	.	.
cord-006860-a3b8hyyr	3204	1	Case	case	NN
cord-006860-a3b8hyyr	3204	2	report	report	NN
cord-006860-a3b8hyyr	3204	3	2	2	CD
cord-006860-a3b8hyyr	3204	4	:	:	:
cord-006860-a3b8hyyr	3205	1	A	a	DT
cord-006860-a3b8hyyr	3205	2	74	74	CD
cord-006860-a3b8hyyr	3205	3	year	year	NN
cord-006860-a3b8hyyr	3205	4	old	old	JJ
cord-006860-a3b8hyyr	3205	5	female	female	JJ
cord-006860-a3b8hyyr	3205	6	patients	patient	NNS
cord-006860-a3b8hyyr	3205	7	suffering	suffer	VBG
cord-006860-a3b8hyyr	3205	8	from	from	IN
cord-006860-a3b8hyyr	3205	9	hip	hip	NN
cord-006860-a3b8hyyr	3205	10	fracture	fracture	NN
cord-006860-a3b8hyyr	3205	11	was	be	VBD
cord-006860-a3b8hyyr	3205	12	treated	treat	VBN
cord-006860-a3b8hyyr	3205	13	by	by	IN
cord-006860-a3b8hyyr	3205	14	surgery	surgery	NN
cord-006860-a3b8hyyr	3205	15	with	with	IN
cord-006860-a3b8hyyr	3205	16	TEP	tep	NN
cord-006860-a3b8hyyr	3205	17	-	-	HYPH
cord-006860-a3b8hyyr	3205	18	operation	operation	NN
cord-006860-a3b8hyyr	3205	19	and	and	CC
cord-006860-a3b8hyyr	3205	20	received	receive	VBD
cord-006860-a3b8hyyr	3205	21	prophylactic	prophylactic	JJ
cord-006860-a3b8hyyr	3205	22	heparin	heparin	NN
cord-006860-a3b8hyyr	3205	23	treatment	treatment	NN
cord-006860-a3b8hyyr	3205	24	.	.	.
cord-006860-a3b8hyyr	3206	1	After	after	IN
cord-006860-a3b8hyyr	3206	2	6	6	CD
cord-006860-a3b8hyyr	3206	3	days	day	NNS
cord-006860-a3b8hyyr	3206	4	,	,	,
cord-006860-a3b8hyyr	3206	5	platelet	platelet	NN
cord-006860-a3b8hyyr	3206	6	count	count	NN
cord-006860-a3b8hyyr	3206	7	decreased	decrease	VBD
cord-006860-a3b8hyyr	3206	8	from	from	IN
cord-006860-a3b8hyyr	3206	9	initially	initially	RB
cord-006860-a3b8hyyr	3206	10	170000	170000	CD
cord-006860-a3b8hyyr	3206	11	to	to	IN
cord-006860-a3b8hyyr	3206	12	8000	8000	CD
cord-006860-a3b8hyyr	3206	13	/	/	SYM
cord-006860-a3b8hyyr	3206	14	ul	ul	NN
cord-006860-a3b8hyyr	3206	15	and	and	CC
cord-006860-a3b8hyyr	3206	16	DVT	DVT	NNP
cord-006860-a3b8hyyr	3206	17	of	of	IN
cord-006860-a3b8hyyr	3206	18	the	the	DT
cord-006860-a3b8hyyr	3206	19	right	right	JJ
cord-006860-a3b8hyyr	3206	20	leg	leg	NN
cord-006860-a3b8hyyr	3206	21	was	be	VBD
cord-006860-a3b8hyyr	3206	22	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	3206	23	.	.	.
cord-006860-a3b8hyyr	3207	1	On	on	IN
cord-006860-a3b8hyyr	3207	2	the	the	DT
cord-006860-a3b8hyyr	3207	3	same	same	JJ
cord-006860-a3b8hyyr	3207	4	day	day	NN
cord-006860-a3b8hyyr	3207	5	,	,	,
cord-006860-a3b8hyyr	3207	6	severe	severe	JJ
cord-006860-a3b8hyyr	3207	7	bleeding	bleeding	NN
cord-006860-a3b8hyyr	3207	8	into	into	IN
cord-006860-a3b8hyyr	3207	9	the	the	DT
cord-006860-a3b8hyyr	3207	10	left	left	JJ
cord-006860-a3b8hyyr	3207	11	leg	leg	NN
cord-006860-a3b8hyyr	3207	12	was	be	VBD
cord-006860-a3b8hyyr	3207	13	observed	observe	VBN
cord-006860-a3b8hyyr	3207	14	and	and	CC
cord-006860-a3b8hyyr	3207	15	hemoglobin	hemoglobin	NN
cord-006860-a3b8hyyr	3207	16	concentration	concentration	NN
cord-006860-a3b8hyyr	3207	17	was	be	VBD
cord-006860-a3b8hyyr	3207	18	diminished	diminish	VBN
cord-006860-a3b8hyyr	3207	19	to	to	IN
cord-006860-a3b8hyyr	3207	20	7.8	7.8	CD
cord-006860-a3b8hyyr	3207	21	g%	g%	NN
cord-006860-a3b8hyyr	3207	22	(	(	-LRB-
cord-006860-a3b8hyyr	3207	23	before	before	IN
cord-006860-a3b8hyyr	3207	24	surgery	surgery	NN
cord-006860-a3b8hyyr	3207	25	16.0	16.0	CD
cord-006860-a3b8hyyr	3207	26	g%	g%	NN
cord-006860-a3b8hyyr	3207	27	)	)	-RRB-
cord-006860-a3b8hyyr	3207	28	.	.	.
cord-006860-a3b8hyyr	3208	1	HIT	HIT	NNP
cord-006860-a3b8hyyr	3208	2	was	be	VBD
cord-006860-a3b8hyyr	3208	3	confirmed	confirm	VBN
cord-006860-a3b8hyyr	3208	4	by	by	IN
cord-006860-a3b8hyyr	3208	5	HIPA	HIPA	NNP
cord-006860-a3b8hyyr	3208	6	te	te	NNP
cord-006860-a3b8hyyr	3209	1	~t	~t	NNP
cord-006860-a3b8hyyr	3209	2	,	,	,
cord-006860-a3b8hyyr	3209	3	heparin	heparin	NNP
cord-006860-a3b8hyyr	3209	4	was	be	VBD
cord-006860-a3b8hyyr	3209	5	stopped	stop	VBN
cord-006860-a3b8hyyr	3209	6	and	and	CC
cord-006860-a3b8hyyr	3209	7	treatment	treatment	NN
cord-006860-a3b8hyyr	3209	8	with	with	IN
cord-006860-a3b8hyyr	3209	9	Orgaran	Orgaran	NNP
cord-006860-a3b8hyyr	3209	10	started	start	VBD
cord-006860-a3b8hyyr	3209	11	.	.	.
cord-006860-a3b8hyyr	3210	1	Thrombocyte	Thrombocyte	NNP
cord-006860-a3b8hyyr	3210	2	count	count	VBP
cord-006860-a3b8hyyr	3210	3	normalized	normalize	VBN
cord-006860-a3b8hyyr	3210	4	and	and	CC
cord-006860-a3b8hyyr	3210	5	no	no	DT
cord-006860-a3b8hyyr	3210	6	further	further	JJ
cord-006860-a3b8hyyr	3210	7	complications	complication	NNS
cord-006860-a3b8hyyr	3210	8	occured	occur	VBD
cord-006860-a3b8hyyr	3210	9	.	.	.
cord-006860-a3b8hyyr	3211	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	3211	2	:	:	:
cord-006860-a3b8hyyr	3211	3	HIT	hit	VB
cord-006860-a3b8hyyr	3211	4	type	type	NN
cord-006860-a3b8hyyr	3211	5	II	ii	NN
cord-006860-a3b8hyyr	3211	6	can	can	MD
cord-006860-a3b8hyyr	3211	7	cause	cause	VB
cord-006860-a3b8hyyr	3211	8	severe	severe	JJ
cord-006860-a3b8hyyr	3211	9	bleeding	bleeding	NN
cord-006860-a3b8hyyr	3211	10	as	as	RB
cord-006860-a3b8hyyr	3211	11	well	well	RB
cord-006860-a3b8hyyr	3211	12	as	as	IN
cord-006860-a3b8hyyr	3211	13	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	3211	14	complications	complication	NNS
cord-006860-a3b8hyyr	3211	15	.	.	.
cord-006860-a3b8hyyr	3212	1	Because	because	IN
cord-006860-a3b8hyyr	3212	2	of	of	IN
cord-006860-a3b8hyyr	3212	3	possible	possible	JJ
cord-006860-a3b8hyyr	3212	4	cross	cross	NN
cord-006860-a3b8hyyr	3212	5	-	-	NN
cord-006860-a3b8hyyr	3212	6	reactivity	reactivity	NN
cord-006860-a3b8hyyr	3212	7	between	between	IN
cord-006860-a3b8hyyr	3212	8	heparin	heparin	NN
cord-006860-a3b8hyyr	3212	9	and	and	CC
cord-006860-a3b8hyyr	3212	10	Orgaran~	orgaran~	CD
cord-006860-a3b8hyyr	3212	11	,	,	,
cord-006860-a3b8hyyr	3212	12	,	,	,
cord-006860-a3b8hyyr	3212	13	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3212	14	should	should	MD
cord-006860-a3b8hyyr	3212	15	be	be	VB
cord-006860-a3b8hyyr	3212	16	given	give	VBN
cord-006860-a3b8hyyr	3212	17	in	in	IN
cord-006860-a3b8hyyr	3212	18	HIT	HIT	VBN
cord-006860-a3b8hyyr	3212	19	patients	patient	NNS
cord-006860-a3b8hyyr	3212	20	.	.	.
cord-006860-a3b8hyyr	3213	1	Currently	currently	RB
cord-006860-a3b8hyyr	3213	2	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3213	3	time	time	NN
cord-006860-a3b8hyyr	3213	4	(	(	-LRB-
cord-006860-a3b8hyyr	3213	5	TI	TI	NNP
cord-006860-a3b8hyyr	3213	6	)	)	-RRB-
cord-006860-a3b8hyyr	3213	7	,	,	,
cord-006860-a3b8hyyr	3213	8	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	3213	9	,	,	,
cord-006860-a3b8hyyr	3213	10	activated	activate	VBN
cord-006860-a3b8hyyr	3213	11	clotting	clotting	NN
cord-006860-a3b8hyyr	3213	12	time	time	NN
cord-006860-a3b8hyyr	3213	13	(	(	-LRB-
cord-006860-a3b8hyyr	3213	14	ACT	ACT	NNP
cord-006860-a3b8hyyr	3213	15	)	)	-RRB-
cord-006860-a3b8hyyr	3213	16	or	or	CC
cord-006860-a3b8hyyr	3213	17	anti	anti	NNP
cord-006860-a3b8hyyr	3213	18	Ila	Ila	NNP
cord-006860-a3b8hyyr	3213	19	-activity	-activity	NNP
cord-006860-a3b8hyyr	3213	20	(	(	-LRB-
cord-006860-a3b8hyyr	3213	21	alia	alia	NNP
cord-006860-a3b8hyyr	3213	22	)	)	-RRB-
cord-006860-a3b8hyyr	3213	23	,	,	,
cord-006860-a3b8hyyr	3213	24	measured	measure	VBN
cord-006860-a3b8hyyr	3213	25	by	by	IN
cord-006860-a3b8hyyr	3213	26	a	a	DT
cord-006860-a3b8hyyr	3213	27	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	3213	28	substrate	substrate	NN
cord-006860-a3b8hyyr	3213	29	test	test	NN
cord-006860-a3b8hyyr	3213	30	are	be	VBP
cord-006860-a3b8hyyr	3213	31	used	use	VBN
cord-006860-a3b8hyyr	3213	32	to	to	TO
cord-006860-a3b8hyyr	3213	33	monitor	monitor	VB
cord-006860-a3b8hyyr	3213	34	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3213	35	treatment	treatment	NN
cord-006860-a3b8hyyr	3213	36	or	or	CC
cord-006860-a3b8hyyr	3213	37	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	3213	38	.	.	.
cord-006860-a3b8hyyr	3214	1	The	the	DT
cord-006860-a3b8hyyr	3214	2	"	"	``
cord-006860-a3b8hyyr	3214	3	13	13	CD
cord-006860-a3b8hyyr	3214	4	"	"	''
cord-006860-a3b8hyyr	3214	5	responds	respond	VBZ
cord-006860-a3b8hyyr	3214	6	very	very	RB
cord-006860-a3b8hyyr	3214	7	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	3214	8	to	to	IN
cord-006860-a3b8hyyr	3214	9	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3214	10	plasma	plasma	NN
cord-006860-a3b8hyyr	3214	11	levels	level	NNS
cord-006860-a3b8hyyr	3215	1	end	end	NN
cord-006860-a3b8hyyr	3215	2	thus	thus	RB
cord-006860-a3b8hyyr	3215	3	requires	require	VBZ
cord-006860-a3b8hyyr	3215	4	variable	variable	JJ
cord-006860-a3b8hyyr	3215	5	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3215	6	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3215	7	.	.	.
cord-006860-a3b8hyyr	3216	1	APTT	APTT	NNP
cord-006860-a3b8hyyr	3216	2	appears	appear	VBZ
cord-006860-a3b8hyyr	3216	3	to	to	TO
cord-006860-a3b8hyyr	3216	4	be	be	VB
cord-006860-a3b8hyyr	3216	5	more	more	RBR
cord-006860-a3b8hyyr	3216	6	adequate	adequate	JJ
cord-006860-a3b8hyyr	3216	7	,	,	,
cord-006860-a3b8hyyr	3216	8	however	however	RB
cord-006860-a3b8hyyr	3216	9	,	,	,
cord-006860-a3b8hyyr	3216	10	it	-PRON-	PRP
cord-006860-a3b8hyyr	3216	11	shows	show	VBZ
cord-006860-a3b8hyyr	3216	12	large	large	JJ
cord-006860-a3b8hyyr	3216	13	interindividual	interindividual	JJ
cord-006860-a3b8hyyr	3216	14	variations	variation	NNS
cord-006860-a3b8hyyr	3216	15	and	and	CC
cord-006860-a3b8hyyr	3216	16	does	do	VBZ
cord-006860-a3b8hyyr	3216	17	not	not	RB
cord-006860-a3b8hyyr	3216	18	respond	respond	VB
cord-006860-a3b8hyyr	3216	19	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	3216	20	enough	enough	RB
cord-006860-a3b8hyyr	3216	21	to	to	IN
cord-006860-a3b8hyyr	3216	22	higher	high	JJR
cord-006860-a3b8hyyr	3216	23	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3216	24	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3216	25	.	.	.
cord-006860-a3b8hyyr	3217	1	ACT	ACT	NNP
cord-006860-a3b8hyyr	3217	2	is	be	VBZ
cord-006860-a3b8hyyr	3217	3	a	a	DT
cord-006860-a3b8hyyr	3217	4	simple	simple	JJ
cord-006860-a3b8hyyr	3217	5	whole	whole	JJ
cord-006860-a3b8hyyr	3217	6	blood	blood	NN
cord-006860-a3b8hyyr	3217	7	clotting	clotting	NN
cord-006860-a3b8hyyr	3217	8	assay	assay	NN
cord-006860-a3b8hyyr	3217	9	,	,	,
cord-006860-a3b8hyyr	3217	10	but	but	CC
cord-006860-a3b8hyyr	3217	11	it	-PRON-	PRP
cord-006860-a3b8hyyr	3217	12	is	be	VBZ
cord-006860-a3b8hyyr	3217	13	strongly	strongly	RB
cord-006860-a3b8hyyr	3217	14	influenced	influence	VBN
cord-006860-a3b8hyyr	3217	15	by	by	IN
cord-006860-a3b8hyyr	3217	16	the	the	DT
cord-006860-a3b8hyyr	3217	17	blood	blood	NN
cord-006860-a3b8hyyr	3217	18	collection	collection	NN
cord-006860-a3b8hyyr	3217	19	technique	technique	NN
cord-006860-a3b8hyyr	3217	20	.	.	.
cord-006860-a3b8hyyr	3218	1	The	the	DT
cord-006860-a3b8hyyr	3218	2	ecadn	ecadn	JJ
cord-006860-a3b8hyyr	3218	3	clotting	clotting	NN
cord-006860-a3b8hyyr	3218	4	time	time	NN
cord-006860-a3b8hyyr	3218	5	(	(	-LRB-
cord-006860-a3b8hyyr	3218	6	ECT	ECT	NNP
cord-006860-a3b8hyyr	3218	7	)	)	-RRB-
cord-006860-a3b8hyyr	3218	8	is	be	VBZ
cord-006860-a3b8hyyr	3218	9	a	a	DT
cord-006860-a3b8hyyr	3218	10	new	new	JJ
cord-006860-a3b8hyyr	3218	11	clotting	clotting	NN
cord-006860-a3b8hyyr	3218	12	assay	assay	NN
cord-006860-a3b8hyyr	3218	13	,	,	,
cord-006860-a3b8hyyr	3218	14	recently	recently	RB
cord-006860-a3b8hyyr	3218	15	described	describe	VBN
cord-006860-a3b8hyyr	3218	16	by	by	IN
cord-006860-a3b8hyyr	3218	17	Nowak	Nowak	NNP
cord-006860-a3b8hyyr	3218	18	and	and	CC
cord-006860-a3b8hyyr	3218	19	Bucha	Bucha	NNP
cord-006860-a3b8hyyr	3218	20	(	(	-LRB-
cord-006860-a3b8hyyr	3218	21	Thromb	Thromb	NNP
cord-006860-a3b8hyyr	3218	22	.	.	.
cord-006860-a3b8hyyr	3219	1	Haemost	Haemost	NNP
cord-006860-a3b8hyyr	3219	2	1993	1993	CD
cord-006860-a3b8hyyr	3219	3	,	,	,
cord-006860-a3b8hyyr	3219	4	69,1306	69,1306	NNP
cord-006860-a3b8hyyr	3219	5	)	)	-RRB-
cord-006860-a3b8hyyr	3219	6	.	.	.
cord-006860-a3b8hyyr	3220	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	3220	2	measures	measure	VBZ
cord-006860-a3b8hyyr	3220	3	the	the	DT
cord-006860-a3b8hyyr	3220	4	clotting	clotting	NN
cord-006860-a3b8hyyr	3220	5	time	time	NN
cord-006860-a3b8hyyr	3220	6	of	of	IN
cord-006860-a3b8hyyr	3220	7	citrated	citrate	VBN
cord-006860-a3b8hyyr	3220	8	blood	blood	NN
cord-006860-a3b8hyyr	3220	9	or	or	CC
cord-006860-a3b8hyyr	3220	10	plasma	plasma	NN
cord-006860-a3b8hyyr	3220	11	after	after	IN
cord-006860-a3b8hyyr	3220	12	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3220	13	activation	activation	NN
cord-006860-a3b8hyyr	3220	14	by	by	IN
cord-006860-a3b8hyyr	3220	15	ecarin	ecarin	NNP
cord-006860-a3b8hyyr	3220	16	,	,	,
cord-006860-a3b8hyyr	3220	17	a	a	DT
cord-006860-a3b8hyyr	3220	18	snake	snake	NN
cord-006860-a3b8hyyr	3220	19	venom	venom	NN
cord-006860-a3b8hyyr	3220	20	of	of	IN
cord-006860-a3b8hyyr	3220	21	echis	echis	NNP
cord-006860-a3b8hyyr	3220	22	carinatus	carinatus	NNP
cord-006860-a3b8hyyr	3220	23	.	.	.
cord-006860-a3b8hyyr	3221	1	EC.T	EC.T	NNP
cord-006860-a3b8hyyr	3221	2	shows	show	VBZ
cord-006860-a3b8hyyr	3221	3	a	a	DT
cord-006860-a3b8hyyr	3221	4	linear	linear	JJ
cord-006860-a3b8hyyr	3221	5	dependence	dependence	NN
cord-006860-a3b8hyyr	3221	6	on	on	IN
cord-006860-a3b8hyyr	3221	7	different	different	JJ
cord-006860-a3b8hyyr	3221	8	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3221	9	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3221	10	over	over	IN
cord-006860-a3b8hyyr	3221	11	a	a	DT
cord-006860-a3b8hyyr	3221	12	wide	wide	JJ
cord-006860-a3b8hyyr	3221	13	concentration	concentration	NN
cord-006860-a3b8hyyr	3221	14	range	range	NN
cord-006860-a3b8hyyr	3221	15	(	(	-LRB-
cord-006860-a3b8hyyr	3221	16	e.g.	e.g.	IN
cord-006860-a3b8hyyr	3221	17	0.1	0.1	CD
cord-006860-a3b8hyyr	3221	18	-	-	SYM
cord-006860-a3b8hyyr	3221	19	5	5	CD
cord-006860-a3b8hyyr	3221	20	pg	pg	NN
cord-006860-a3b8hyyr	3221	21	/	/	SYM
cord-006860-a3b8hyyr	3221	22	ml	ml	NNP
cord-006860-a3b8hyyr	3221	23	)	)	-RRB-
cord-006860-a3b8hyyr	3221	24	.	.	.
cord-006860-a3b8hyyr	3222	1	In	in	IN
cord-006860-a3b8hyyr	3222	2	a	a	DT
cord-006860-a3b8hyyr	3222	3	clinical	clinical	JJ
cord-006860-a3b8hyyr	3222	4	interaction	interaction	NN
cord-006860-a3b8hyyr	3222	5	study	study	NN
cord-006860-a3b8hyyr	3222	6	healthy	healthy	JJ
cord-006860-a3b8hyyr	3222	7	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	3222	8	were	be	VBD
cord-006860-a3b8hyyr	3222	9	administered	administer	VBN
cord-006860-a3b8hyyr	3222	10	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3222	11	,	,	,
cord-006860-a3b8hyyr	3222	12	ASA	ASA	NNP
cord-006860-a3b8hyyr	3222	13	or	or	CC
cord-006860-a3b8hyyr	3222	14	both	both	DT
cord-006860-a3b8hyyr	3222	15	.	.	.
cord-006860-a3b8hyyr	3223	1	15	15	CD
cord-006860-a3b8hyyr	3223	2	male	male	JJ
cord-006860-a3b8hyyr	3223	3	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	3223	4	received	receive	VBD
cord-006860-a3b8hyyr	3223	5	an	an	DT
cord-006860-a3b8hyyr	3223	6	i.v	i.v	NNP
cord-006860-a3b8hyyr	3223	7	.	.	.
cord-006860-a3b8hyyr	3223	8	infusion	infusion	NN
cord-006860-a3b8hyyr	3223	9	of	of	IN
cord-006860-a3b8hyyr	3223	10	PEG	PEG	NNP
cord-006860-a3b8hyyr	3223	11	-	-	HYPH
cord-006860-a3b8hyyr	3223	12	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3223	13	(	(	-LRB-
cord-006860-a3b8hyyr	3223	14	0.02	0.02	CD
cord-006860-a3b8hyyr	3223	15	mg	mg	NNP
cord-006860-a3b8hyyr	3223	16	/	/	SYM
cord-006860-a3b8hyyr	3223	17	kg	kg	NNP
cord-006860-a3b8hyyr	3223	18	/	/	SYM
cord-006860-a3b8hyyr	3223	19	h	h	NN
cord-006860-a3b8hyyr	3223	20	)	)	-RRB-
cord-006860-a3b8hyyr	3223	21	for	for	IN
cord-006860-a3b8hyyr	3223	22	24	24	CD
cord-006860-a3b8hyyr	3223	23	hours	hour	NNS
cord-006860-a3b8hyyr	3223	24	after	after	IN
cord-006860-a3b8hyyr	3223	25	an	an	DT
cord-006860-a3b8hyyr	3223	26	initial	initial	JJ
cord-006860-a3b8hyyr	3223	27	i.v	i.v	NNP
cord-006860-a3b8hyyr	3223	28	.	.	NNP
cord-006860-a3b8hyyr	3223	29	bolus	bolus	NNP
cord-006860-a3b8hyyr	3223	30	of	of	IN
cord-006860-a3b8hyyr	3223	31	0.2	0.2	CD
cord-006860-a3b8hyyr	3223	32	mg	mg	NNP
cord-006860-a3b8hyyr	3223	33	/	/	SYM
cord-006860-a3b8hyyr	3223	34	kg	kg	NNP
cord-006860-a3b8hyyr	3223	35	to	to	TO
cord-006860-a3b8hyyr	3223	36	compare	compare	VB
cord-006860-a3b8hyyr	3223	37	the	the	DT
cord-006860-a3b8hyyr	3223	38	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	3223	39	and	and	CC
cord-006860-a3b8hyyr	3223	40	reliability	reliability	NN
cord-006860-a3b8hyyr	3223	41	of	of	IN
cord-006860-a3b8hyyr	3223	42	ECT	ECT	NNP
cord-006860-a3b8hyyr	3223	43	with	with	IN
cord-006860-a3b8hyyr	3223	44	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	3223	45	,	,	,
cord-006860-a3b8hyyr	3223	46	l	l	NN
cord-006860-a3b8hyyr	3223	47	-	-	HYPH
cord-006860-a3b8hyyr	3223	48	r	r	NNP
cord-006860-a3b8hyyr	3223	49	end	end	NN
cord-006860-a3b8hyyr	3223	50	ACT	ACT	NNP
cord-006860-a3b8hyyr	3223	51	.	.	.
cord-006860-a3b8hyyr	3224	1	The	the	DT
cord-006860-a3b8hyyr	3224	2	ACT	ACT	NNP
cord-006860-a3b8hyyr	3224	3	was	be	VBD
cord-006860-a3b8hyyr	3224	4	measured	measure	VBN
cord-006860-a3b8hyyr	3224	5	on	on	IN
cord-006860-a3b8hyyr	3224	6	the	the	DT
cord-006860-a3b8hyyr	3224	7	Hemochron	Hemochron	NNP
cord-006860-a3b8hyyr	3224	8	801	801	CD
cord-006860-a3b8hyyr	3224	9	,	,	,
cord-006860-a3b8hyyr	3224	10	USA	USA	NNP
cord-006860-a3b8hyyr	3224	11	,	,	,
cord-006860-a3b8hyyr	3224	12	ECT	ECT	NNP
cord-006860-a3b8hyyr	3224	13	on	on	IN
cord-006860-a3b8hyyr	3224	14	a	a	DT
cord-006860-a3b8hyyr	3224	15	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3224	16	timer	timer	NN
cord-006860-a3b8hyyr	3224	17	,	,	,
cord-006860-a3b8hyyr	3224	18	aPTF	aptf	NN
cord-006860-a3b8hyyr	3225	1	using	use	VBG
cord-006860-a3b8hyyr	3225	2	the	the	DT
cord-006860-a3b8hyyr	3225	3	APTT	APTT	NNP
cord-006860-a3b8hyyr	3225	4	lyophylized	lyophylize	VBD
cord-006860-a3b8hyyr	3225	5	Silica	Silica	NNP
cord-006860-a3b8hyyr	3225	6	reagent	reagent	NN
cord-006860-a3b8hyyr	3225	7	by	by	IN
cord-006860-a3b8hyyr	3225	8	IL	IL	NNP
cord-006860-a3b8hyyr	3225	9	and	and	CC
cord-006860-a3b8hyyr	3225	10	alia	alia	NNP
cord-006860-a3b8hyyr	3225	11	on	on	IN
cord-006860-a3b8hyyr	3225	12	an	an	DT
cord-006860-a3b8hyyr	3225	13	ACL	ACL	NNP
cord-006860-a3b8hyyr	3226	1	(	(	-LRB-
cord-006860-a3b8hyyr	3226	2	IL	IL	NNP
cord-006860-a3b8hyyr	3226	3	-	-	HYPH
cord-006860-a3b8hyyr	3226	4	Milan	Milan	NNP
cord-006860-a3b8hyyr	3226	5	)	)	-RRB-
cord-006860-a3b8hyyr	3227	1	with	with	IN
cord-006860-a3b8hyyr	3227	2	the	the	DT
cord-006860-a3b8hyyr	3227	3	chromogenic	chromogenic	NNP
cord-006860-a3b8hyyr	3227	4	substrate	substrate	NN
cord-006860-a3b8hyyr	3227	5	2238	2238	CD
cord-006860-a3b8hyyr	3227	6	.	.	.
cord-006860-a3b8hyyr	3228	1	All	all	DT
cord-006860-a3b8hyyr	3228	2	tests	test	NNS
cord-006860-a3b8hyyr	3228	3	were	be	VBD
cord-006860-a3b8hyyr	3228	4	performed	perform	VBN
cord-006860-a3b8hyyr	3228	5	in	in	IN
cord-006860-a3b8hyyr	3228	6	duplicate	duplicate	NN
cord-006860-a3b8hyyr	3228	7	.	.	.
cord-006860-a3b8hyyr	3229	1	ECT	ECT	NNP
cord-006860-a3b8hyyr	3229	2	was	be	VBD
cord-006860-a3b8hyyr	3229	3	more	more	RBR
cord-006860-a3b8hyyr	3229	4	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	3229	5	to	to	IN
cord-006860-a3b8hyyr	3229	6	different	different	JJ
cord-006860-a3b8hyyr	3229	7	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3229	8	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3229	9	than	than	IN
cord-006860-a3b8hyyr	3229	10	aPTT	aptt	CD
cord-006860-a3b8hyyr	3229	11	,	,	,
cord-006860-a3b8hyyr	3229	12	or	or	CC
cord-006860-a3b8hyyr	3229	13	ACT	ACT	NNP
cord-006860-a3b8hyyr	3229	14	.	.	.
cord-006860-a3b8hyyr	3230	1	The	the	DT
cord-006860-a3b8hyyr	3230	2	ECT	ECT	NNP
cord-006860-a3b8hyyr	3230	3	results	result	NNS
cord-006860-a3b8hyyr	3230	4	were	be	VBD
cord-006860-a3b8hyyr	3230	5	better	well	RBR
cord-006860-a3b8hyyr	3230	6	correlated	correlate	VBN
cord-006860-a3b8hyyr	3230	7	with	with	IN
cord-006860-a3b8hyyr	3230	8	the	the	DT
cord-006860-a3b8hyyr	3230	9	alia	alia	NN
cord-006860-a3b8hyyr	3230	10	-	-	HYPH
cord-006860-a3b8hyyr	3230	11	activity	activity	NN
cord-006860-a3b8hyyr	3230	12	than	than	IN
cord-006860-a3b8hyyr	3230	13	aP'l"r	ap'l"r	DT
cord-006860-a3b8hyyr	3230	14	and	and	CC
cord-006860-a3b8hyyr	3230	15	ACT	ACT	NNP
cord-006860-a3b8hyyr	3230	16	.	.	.
cord-006860-a3b8hyyr	3231	1	The	the	DT
cord-006860-a3b8hyyr	3231	2	lower	low	JJR
cord-006860-a3b8hyyr	3231	3	detection	detection	NN
cord-006860-a3b8hyyr	3231	4	range	range	NN
cord-006860-a3b8hyyr	3231	5	for	for	IN
cord-006860-a3b8hyyr	3231	6	ECT	ECT	NNP
cord-006860-a3b8hyyr	3231	7	is	be	VBZ
cord-006860-a3b8hyyr	3231	8	0.05	0.05	CD
cord-006860-a3b8hyyr	3231	9	pg	pg	NNP
cord-006860-a3b8hyyr	3231	10	/	/	SYM
cord-006860-a3b8hyyr	3231	11	ml	ml	NNP
cord-006860-a3b8hyyr	3231	12	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	3231	13	.	.	.
cord-006860-a3b8hyyr	3232	1	ECT	ECT	NNP
cord-006860-a3b8hyyr	3232	2	is	be	VBZ
cord-006860-a3b8hyyr	3232	3	a	a	DT
cord-006860-a3b8hyyr	3232	4	very	very	RB
cord-006860-a3b8hyyr	3232	5	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	3232	6	,	,	,
cord-006860-a3b8hyyr	3232	7	simple	simple	JJ
cord-006860-a3b8hyyr	3232	8	and	and	CC
cord-006860-a3b8hyyr	3232	9	reliable	reliable	JJ
cord-006860-a3b8hyyr	3232	10	test	test	NN
cord-006860-a3b8hyyr	3232	11	for	for	IN
cord-006860-a3b8hyyr	3232	12	the	the	DT
cord-006860-a3b8hyyr	3232	13	monitoring	monitoring	NN
cord-006860-a3b8hyyr	3232	14	of	of	IN
cord-006860-a3b8hyyr	3232	15	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3232	16	treatment	treatment	NN
cord-006860-a3b8hyyr	3232	17	and	and	CC
cord-006860-a3b8hyyr	3232	18	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	3232	19	.	.	.
cord-006860-a3b8hyyr	3233	1	Recombinant	recombinant	JJ
cord-006860-a3b8hyyr	3233	2	and	and	CC
cord-006860-a3b8hyyr	3233	3	synthetic	synthetic	JJ
cord-006860-a3b8hyyr	3233	4	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3233	5	of	of	IN
cord-006860-a3b8hyyr	3233	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3233	7	such	such	JJ
cord-006860-a3b8hyyr	3233	8	as	as	IN
cord-006860-a3b8hyyr	3233	9	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3233	10	,	,	,
cord-006860-a3b8hyyr	3233	11	efegatran	efegatran	NN
cord-006860-a3b8hyyr	3233	12	and	and	CC
cord-006860-a3b8hyyr	3233	13	argatroban	argatroban	NNP
cord-006860-a3b8hyyr	3233	14	are	be	VBP
cord-006860-a3b8hyyr	3233	15	currently	currently	RB
cord-006860-a3b8hyyr	3233	16	in	in	IN
cord-006860-a3b8hyyr	3233	17	various	various	JJ
cord-006860-a3b8hyyr	3233	18	phases	phase	NNS
cord-006860-a3b8hyyr	3233	19	of	of	IN
cord-006860-a3b8hyyr	3233	20	clinical	clinical	JJ
cord-006860-a3b8hyyr	3233	21	trials	trial	NNS
cord-006860-a3b8hyyr	3233	22	in	in	IN
cord-006860-a3b8hyyr	3233	23	several	several	JJ
cord-006860-a3b8hyyr	3233	24	surgical	surgical	JJ
cord-006860-a3b8hyyr	3233	25	and	and	CC
cord-006860-a3b8hyyr	3233	26	medical	medical	JJ
cord-006860-a3b8hyyr	3233	27	indications	indication	NNS
cord-006860-a3b8hyyr	3233	28	.	.	.
cord-006860-a3b8hyyr	3234	1	The	the	DT
cord-006860-a3b8hyyr	3234	2	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	3234	3	effects	effect	NNS
cord-006860-a3b8hyyr	3234	4	of	of	IN
cord-006860-a3b8hyyr	3234	5	these	these	DT
cord-006860-a3b8hyyr	3234	6	agents	agent	NNS
cord-006860-a3b8hyyr	3234	7	are	be	VBP
cord-006860-a3b8hyyr	3234	8	usually	usually	RB
cord-006860-a3b8hyyr	3234	9	monitored	monitor	VBN
cord-006860-a3b8hyyr	3234	10	by	by	IN
cord-006860-a3b8hyyr	3234	11	APTT	APTT	NNP
cord-006860-a3b8hyyr	3234	12	whereas	whereas	IN
cord-006860-a3b8hyyr	3234	13	in	in	IN
cord-006860-a3b8hyyr	3234	14	cardiovascular	cardiovascular	JJ
cord-006860-a3b8hyyr	3234	15	indications	indication	NNS
cord-006860-a3b8hyyr	3234	16	,	,	,
cord-006860-a3b8hyyr	3234	17	cefite	cefite	NNP
cord-006860-a3b8hyyr	3234	18	ACT	ACT	NNP
cord-006860-a3b8hyyr	3234	19	and	and	CC
cord-006860-a3b8hyyr	3234	20	Hemotech	Hemotech	NNP
cord-006860-a3b8hyyr	3234	21	®	®	NNP
cord-006860-a3b8hyyr	3234	22	ACT	ACT	NNP
cord-006860-a3b8hyyr	3234	23	are	be	VBP
cord-006860-a3b8hyyr	3234	24	used	use	VBN
cord-006860-a3b8hyyr	3234	25	.	.	.
cord-006860-a3b8hyyr	3235	1	The	the	DT
cord-006860-a3b8hyyr	3235	2	reliability	reliability	NN
cord-006860-a3b8hyyr	3235	3	of	of	IN
cord-006860-a3b8hyyr	3235	4	both	both	CC
cord-006860-a3b8hyyr	3235	5	APTT	APTT	NNP
cord-006860-a3b8hyyr	3235	6	and	and	CC
cord-006860-a3b8hyyr	3235	7	the	the	DT
cord-006860-a3b8hyyr	3235	8	ACT	ACT	NNP
cord-006860-a3b8hyyr	3235	9	tests	test	NNS
cord-006860-a3b8hyyr	3235	10	in	in	IN
cord-006860-a3b8hyyr	3235	11	predieting	prediete	VBG
cord-006860-a3b8hyyr	3235	12	the	the	DT
cord-006860-a3b8hyyr	3235	13	safety	safety	NN
cord-006860-a3b8hyyr	3235	14	of	of	IN
cord-006860-a3b8hyyr	3235	15	various	various	JJ
cord-006860-a3b8hyyr	3235	16	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3235	17	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3235	18	has	have	VBZ
cord-006860-a3b8hyyr	3235	19	been	be	VBN
cord-006860-a3b8hyyr	3235	20	heavily	heavily	RB
cord-006860-a3b8hyyr	3235	21	debated	debate	VBN
cord-006860-a3b8hyyr	3235	22	.	.	.
cord-006860-a3b8hyyr	3236	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	3236	2	,	,	,
cord-006860-a3b8hyyr	3236	3	some	some	DT
cord-006860-a3b8hyyr	3236	4	of	of	IN
cord-006860-a3b8hyyr	3236	5	these	these	DT
cord-006860-a3b8hyyr	3236	6	inkibiturs	inkibitur	NNS
cord-006860-a3b8hyyr	3236	7	are	be	VBP
cord-006860-a3b8hyyr	3236	8	administered	administer	VBN
cord-006860-a3b8hyyr	3236	9	simultaneously	simultaneously	RB
cord-006860-a3b8hyyr	3236	10	to	to	IN
cord-006860-a3b8hyyr	3236	11	heperinized	heperinized	VB
cord-006860-a3b8hyyr	3236	12	or	or	CC
cord-006860-a3b8hyyr	3236	13	coumadinized	coumadinize	VBN
cord-006860-a3b8hyyr	3236	14	patients	patient	NNS
cord-006860-a3b8hyyr	3236	15	and	and	CC
cord-006860-a3b8hyyr	3236	16	the	the	DT
cord-006860-a3b8hyyr	3236	17	obtained	obtain	VBN
cord-006860-a3b8hyyr	3236	18	APTT	APTT	NNP
cord-006860-a3b8hyyr	3236	19	and	and	CC
cord-006860-a3b8hyyr	3236	20	ACT	ACT	NNP
cord-006860-a3b8hyyr	3236	21	results	result	NNS
cord-006860-a3b8hyyr	3236	22	do	do	VBP
cord-006860-a3b8hyyr	3236	23	not	not	RB
cord-006860-a3b8hyyr	3236	24	lady	lady	NN
cord-006860-a3b8hyyr	3236	25	refleot	refleot	VB
cord-006860-a3b8hyyr	3236	26	the	the	DT
cord-006860-a3b8hyyr	3236	27	effects	effect	NNS
cord-006860-a3b8hyyr	3236	28	of	of	IN
cord-006860-a3b8hyyr	3236	29	these	these	DT
cord-006860-a3b8hyyr	3236	30	agents	agent	NNS
cord-006860-a3b8hyyr	3236	31	.	.	.
cord-006860-a3b8hyyr	3237	1	Fcafin	Fcafin	NNP
cord-006860-a3b8hyyr	3237	2	is	be	VBZ
cord-006860-a3b8hyyr	3237	3	a	a	DT
cord-006860-a3b8hyyr	3237	4	snake	snake	NN
cord-006860-a3b8hyyr	3237	5	venom	venom	NN
cord-006860-a3b8hyyr	3237	6	derived	derive	VBN
cord-006860-a3b8hyyr	3237	7	fi'om	fi'om	NNP
cord-006860-a3b8hyyr	3237	8	Echis	Echis	NNP
cord-006860-a3b8hyyr	3237	9	carinatus	carinatus	NN
cord-006860-a3b8hyyr	3237	10	which	which	WDT
cord-006860-a3b8hyyr	3237	11	converts	convert	VBZ
cord-006860-a3b8hyyr	3237	12	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3237	13	into	into	IN
cord-006860-a3b8hyyr	3237	14	mesothrombin	mesothrombin	NNP
cord-006860-a3b8hyyr	3237	15	,	,	,
cord-006860-a3b8hyyr	3237	16	targeting	target	VBG
cord-006860-a3b8hyyr	3237	17	the	the	DT
cord-006860-a3b8hyyr	3237	18	Arg~3-Ile	Arg~3-Ile	NNP
cord-006860-a3b8hyyr	3237	19	TM	TM	NNP
cord-006860-a3b8hyyr	3237	20	bond	bond	NN
cord-006860-a3b8hyyr	3237	21	between	between	IN
cord-006860-a3b8hyyr	3237	22	the	the	DT
cord-006860-a3b8hyyr	3237	23	A	a	NN
cord-006860-a3b8hyyr	3237	24	and	and	CC
cord-006860-a3b8hyyr	3237	25	B	b	NN
cord-006860-a3b8hyyr	3237	26	chains	chain	NNS
cord-006860-a3b8hyyr	3237	27	of	of	IN
cord-006860-a3b8hyyr	3237	28	prothrombm	prothrombm	NNS
cord-006860-a3b8hyyr	3237	29	.	.	.
cord-006860-a3b8hyyr	3238	1	While	while	IN
cord-006860-a3b8hyyr	3238	2	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3238	3	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3238	4	are	be	VBP
cord-006860-a3b8hyyr	3238	5	capable	capable	JJ
cord-006860-a3b8hyyr	3238	6	of	of	IN
cord-006860-a3b8hyyr	3238	7	inhibiting	inhibit	VBG
cord-006860-a3b8hyyr	3238	8	mesothrombin	mesothrombin	NNP
cord-006860-a3b8hyyr	3238	9	,	,	,
cord-006860-a3b8hyyr	3238	10	ATIII	ATIII	NNP
cord-006860-a3b8hyyr	3238	11	/	/	SYM
cord-006860-a3b8hyyr	3238	12	beparin	beparin	NN
cord-006860-a3b8hyyr	3238	13	complex	complex	NN
cord-006860-a3b8hyyr	3238	14	does	do	VBZ
cord-006860-a3b8hyyr	3238	15	not	not	RB
cord-006860-a3b8hyyr	3238	16	have	have	VB
cord-006860-a3b8hyyr	3238	17	any	any	DT
cord-006860-a3b8hyyr	3238	18	effect	effect	NN
cord-006860-a3b8hyyr	3238	19	.	.	.
cord-006860-a3b8hyyr	3239	1	Using	use	VBG
cord-006860-a3b8hyyr	3239	2	purified	purify	VBN
cord-006860-a3b8hyyr	3239	3	ecarin	ecarin	NN
cord-006860-a3b8hyyr	3239	4	,	,	,
cord-006860-a3b8hyyr	3239	5	Nowak	Nowak	NNP
cord-006860-a3b8hyyr	3239	6	and	and	CC
cord-006860-a3b8hyyr	3239	7	Bucha	Bucha	NNP
cord-006860-a3b8hyyr	3239	8	(	(	-LRB-
cord-006860-a3b8hyyr	3239	9	1993	1993	CD
cord-006860-a3b8hyyr	3239	10	Thromb	Thromb	NNP
cord-006860-a3b8hyyr	3239	11	Haemost	Haemost	NNP
cord-006860-a3b8hyyr	3239	12	69:1306	69:1306	CD
cord-006860-a3b8hyyr	3239	13	)	)	-RRB-
cord-006860-a3b8hyyr	3239	14	proposed	propose	VBD
cord-006860-a3b8hyyr	3239	15	to	to	TO
cord-006860-a3b8hyyr	3239	16	assay	assay	VB
cord-006860-a3b8hyyr	3239	17	hirudin	hirudin	RB
cord-006860-a3b8hyyr	3239	18	.	.	.
cord-006860-a3b8hyyr	3240	1	Since	since	IN
cord-006860-a3b8hyyr	3240	2	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3240	3	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3240	4	exhibit	exhibit	VBP
cord-006860-a3b8hyyr	3240	5	similar	similar	JJ
cord-006860-a3b8hyyr	3240	6	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	3240	7	of	of	IN
cord-006860-a3b8hyyr	3240	8	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3240	9	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3240	10	,	,	,
cord-006860-a3b8hyyr	3240	11	ecarin	ecarin	NNP
cord-006860-a3b8hyyr	3240	12	clotting	clotting	NN
cord-006860-a3b8hyyr	3240	13	time	time	NN
cord-006860-a3b8hyyr	3240	14	(	(	-LRB-
cord-006860-a3b8hyyr	3240	15	ECT	ECT	NNP
cord-006860-a3b8hyyr	3240	16	)	)	-RRB-
cord-006860-a3b8hyyr	3240	17	was	be	VBD
cord-006860-a3b8hyyr	3240	18	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	3240	19	to	to	TO
cord-006860-a3b8hyyr	3240	20	test	test	VB
cord-006860-a3b8hyyr	3240	21	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3240	22	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	3240	23	efficacy	efficacy	NN
cord-006860-a3b8hyyr	3240	24	in	in	IN
cord-006860-a3b8hyyr	3240	25	various	various	JJ
cord-006860-a3b8hyyr	3240	26	experimental	experimental	JJ
cord-006860-a3b8hyyr	3240	27	and	and	CC
cord-006860-a3b8hyyr	3240	28	clinical	clinical	JJ
cord-006860-a3b8hyyr	3240	29	settings	setting	NNS
cord-006860-a3b8hyyr	3240	30	.	.	.
cord-006860-a3b8hyyr	3241	1	Lyphilized	Lyphilized	NNP
cord-006860-a3b8hyyr	3241	2	eoarin	eoarin	NNP
cord-006860-a3b8hyyr	3241	3	was	be	VBD
cord-006860-a3b8hyyr	3241	4	obtained	obtain	VBN
cord-006860-a3b8hyyr	3241	5	from	from	IN
cord-006860-a3b8hyyr	3241	6	Knoll	Knoll	NNP
cord-006860-a3b8hyyr	3241	7	AG	AG	NNP
cord-006860-a3b8hyyr	3241	8	,	,	,
cord-006860-a3b8hyyr	3241	9	Ludwigshafen	Ludwigshafen	NNP
cord-006860-a3b8hyyr	3241	10	,	,	,
cord-006860-a3b8hyyr	3241	11	Germany	Germany	NNP
cord-006860-a3b8hyyr	3241	12	)	)	-RRB-
cord-006860-a3b8hyyr	3241	13	.	.	.
cord-006860-a3b8hyyr	3242	1	Concentration	concentration	NN
cord-006860-a3b8hyyr	3242	2	dependent	dependent	JJ
cord-006860-a3b8hyyr	3242	3	clotting	clotting	NN
cord-006860-a3b8hyyr	3242	4	times	time	NNS
cord-006860-a3b8hyyr	3242	5	for	for	IN
cord-006860-a3b8hyyr	3242	6	himdin	himdin	NNP
cord-006860-a3b8hyyr	3242	7	,	,	,
cord-006860-a3b8hyyr	3242	8	efegatran	efegatran	NN
cord-006860-a3b8hyyr	3242	9	and	and	CC
cord-006860-a3b8hyyr	3242	10	argatroban	argatroban	NNP
cord-006860-a3b8hyyr	3242	11	were	be	VBD
cord-006860-a3b8hyyr	3242	12	obtained	obtain	VBN
cord-006860-a3b8hyyr	3242	13	in	in	IN
cord-006860-a3b8hyyr	3242	14	a	a	DT
cord-006860-a3b8hyyr	3242	15	range	range	NN
cord-006860-a3b8hyyr	3242	16	of	of	IN
cord-006860-a3b8hyyr	3242	17	0	0	CD
cord-006860-a3b8hyyr	3242	18	-	-	SYM
cord-006860-a3b8hyyr	3242	19	15	15	CD
cord-006860-a3b8hyyr	3242	20	p.g	p.g	NNP
cord-006860-a3b8hyyr	3242	21	/	/	SYM
cord-006860-a3b8hyyr	3242	22	ml	ml	NN
cord-006860-a3b8hyyr	3242	23	.	.	.
cord-006860-a3b8hyyr	3243	1	All	all	DT
cord-006860-a3b8hyyr	3243	2	of	of	IN
cord-006860-a3b8hyyr	3243	3	the	the	DT
cord-006860-a3b8hyyr	3243	4	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3243	5	agents	agent	NNS
cord-006860-a3b8hyyr	3243	6	produced	produce	VBD
cord-006860-a3b8hyyr	3243	7	a	a	DT
cord-006860-a3b8hyyr	3243	8	concentration	concentration	NN
cord-006860-a3b8hyyr	3243	9	dependent	dependent	JJ
cord-006860-a3b8hyyr	3243	10	prolongation	prolongation	NN
cord-006860-a3b8hyyr	3243	11	of	of	IN
cord-006860-a3b8hyyr	3243	12	ECT	ECT	NNP
cord-006860-a3b8hyyr	3243	13	and	and	CC
cord-006860-a3b8hyyr	3243	14	showed	show	VBD
cord-006860-a3b8hyyr	3243	15	va~	va~	.
cord-006860-a3b8hyyr	3244	1	Angpotendies	angpotendie	NNS
cord-006860-a3b8hyyr	3244	2	inthe	inthe	DT
cord-006860-a3b8hyyr	3244	3	order	order	NN
cord-006860-a3b8hyyr	3244	4	ofefegatran	ofefegatran	NN
cord-006860-a3b8hyyr	3244	5	>	>	XX
cord-006860-a3b8hyyr	3245	1	argatreban	argatreban	NNP
cord-006860-a3b8hyyr	3245	2	>	>	XX
cord-006860-a3b8hyyr	3246	1	hirudin	hirudin	NNP
cord-006860-a3b8hyyr	3246	2	,	,	,
cord-006860-a3b8hyyr	3246	3	on	on	IN
cord-006860-a3b8hyyr	3246	4	a	a	DT
cord-006860-a3b8hyyr	3246	5	gravimetriebasis	gravimetriebasis	NN
cord-006860-a3b8hyyr	3246	6	.	.	.
cord-006860-a3b8hyyr	3247	1	On	on	IN
cord-006860-a3b8hyyr	3247	2	a	a	DT
cord-006860-a3b8hyyr	3247	3	molar	molar	JJ
cord-006860-a3b8hyyr	3247	4	basis	basis	NN
cord-006860-a3b8hyyr	3247	5	,	,	,
cord-006860-a3b8hyyr	3247	6	the	the	DT
cord-006860-a3b8hyyr	3247	7	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3247	8	order	order	NN
cord-006860-a3b8hyyr	3247	9	of	of	IN
cord-006860-a3b8hyyr	3247	10	potency	potency	NN
cord-006860-a3b8hyyr	3247	11	was	be	VBD
cord-006860-a3b8hyyr	3247	12	found	find	VBN
cord-006860-a3b8hyyr	3247	13	to	to	TO
cord-006860-a3b8hyyr	3247	14	be	be	VB
cord-006860-a3b8hyyr	3247	15	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3247	16	>	>	XX
cord-006860-a3b8hyyr	3247	17	afegatran	afegatran	NNP
cord-006860-a3b8hyyr	3247	18	>	>	XX
cord-006860-a3b8hyyr	3247	19	argatroban	argatroban	NNP
cord-006860-a3b8hyyr	3247	20	.	.	.
cord-006860-a3b8hyyr	3248	1	Utilizing	utilize	VBG
cord-006860-a3b8hyyr	3248	2	the	the	DT
cord-006860-a3b8hyyr	3248	3	ECT	ECT	NNPS
cord-006860-a3b8hyyr	3248	4	,	,	,
cord-006860-a3b8hyyr	3248	5	the	the	DT
cord-006860-a3b8hyyr	3248	6	effect	effect	NN
cord-006860-a3b8hyyr	3248	7	of	of	IN
cord-006860-a3b8hyyr	3248	8	these	these	DT
cord-006860-a3b8hyyr	3248	9	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3248	10	on	on	IN
cord-006860-a3b8hyyr	3248	11	patients	patient	NNS
cord-006860-a3b8hyyr	3248	12	undergoing	undergo	VBG
cord-006860-a3b8hyyr	3248	13	bolus	bolus	NN
cord-006860-a3b8hyyr	3248	14	or	or	CC
cord-006860-a3b8hyyr	3248	15	infusion	infusion	NN
cord-006860-a3b8hyyr	3248	16	therapy	therapy	NN
cord-006860-a3b8hyyr	3248	17	,	,	,
cord-006860-a3b8hyyr	3248	18	resulting	result	VBG
cord-006860-a3b8hyyr	3248	19	in	in	IN
cord-006860-a3b8hyyr	3248	20	a	a	DT
cord-006860-a3b8hyyr	3248	21	concentration	concentration	NN
cord-006860-a3b8hyyr	3248	22	level	level	NN
cord-006860-a3b8hyyr	3248	23	of	of	IN
cord-006860-a3b8hyyr	3248	24	~	~	CD
cord-006860-a3b8hyyr	3248	25	10	10	CD
cord-006860-a3b8hyyr	3248	26	gt	gt	NN
cord-006860-a3b8hyyr	3248	27	g	g	NN
cord-006860-a3b8hyyr	3248	28	/	/	SYM
cord-006860-a3b8hyyr	3248	29	rnt	rnt	NNP
cord-006860-a3b8hyyr	3248	30	,	,	,
cord-006860-a3b8hyyr	3248	31	have	have	VBP
cord-006860-a3b8hyyr	3248	32	been	be	VBN
cord-006860-a3b8hyyr	3248	33	measured	measure	VBN
cord-006860-a3b8hyyr	3248	34	.	.	.
cord-006860-a3b8hyyr	3249	1	Unlike	unlike	IN
cord-006860-a3b8hyyr	3249	2	such	such	JJ
cord-006860-a3b8hyyr	3249	3	global	global	JJ
cord-006860-a3b8hyyr	3249	4	tests	test	NNS
cord-006860-a3b8hyyr	3249	5	as	as	IN
cord-006860-a3b8hyyr	3249	6	PT	PT	NNP
cord-006860-a3b8hyyr	3249	7	and	and	CC
cord-006860-a3b8hyyr	3249	8	APTT	APTT	NNP
cord-006860-a3b8hyyr	3249	9	,	,	,
cord-006860-a3b8hyyr	3249	10	patients	patient	NNS
cord-006860-a3b8hyyr	3249	11	receiving	receive	VBG
cord-006860-a3b8hyyr	3249	12	simultaneous	simultaneous	JJ
cord-006860-a3b8hyyr	3249	13	heparin	heparin	NN
cord-006860-a3b8hyyr	3249	14	or	or	CC
cord-006860-a3b8hyyr	3249	15	oral	oral	JJ
cord-006860-a3b8hyyr	3249	16	anticeagulants	anticeagulant	NNS
cord-006860-a3b8hyyr	3249	17	can	can	MD
cord-006860-a3b8hyyr	3249	18	be	be	VB
cord-006860-a3b8hyyr	3249	19	monitored	monitor	VBN
cord-006860-a3b8hyyr	3249	20	for	for	IN
cord-006860-a3b8hyyr	3249	21	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3249	22	specific	specific	JJ
cord-006860-a3b8hyyr	3249	23	prolongation	prolongation	NN
cord-006860-a3b8hyyr	3249	24	ofthe	ofthe	DT
cord-006860-a3b8hyyr	3249	25	ECT	ECT	NNP
cord-006860-a3b8hyyr	3249	26	.	.	.
cord-006860-a3b8hyyr	3250	1	Plasma	plasma	NN
cord-006860-a3b8hyyr	3250	2	samples	sample	NNS
cord-006860-a3b8hyyr	3250	3	from	from	IN
cord-006860-a3b8hyyr	3250	4	heparinized	heparinize	VBN
cord-006860-a3b8hyyr	3250	5	(	(	-LRB-
cord-006860-a3b8hyyr	3250	6	APTT	APTT	NNP
cord-006860-a3b8hyyr	3250	7	45	45	CD
cord-006860-a3b8hyyr	3250	8	-	-	SYM
cord-006860-a3b8hyyr	3250	9	90	90	CD
cord-006860-a3b8hyyr	3250	10	sec	sec	NNP
cord-006860-a3b8hyyr	3250	11	)	)	-RRB-
cord-006860-a3b8hyyr	3250	12	or	or	CC
cord-006860-a3b8hyyr	3250	13	coumadinized	coumadinize	VBN
cord-006860-a3b8hyyr	3250	14	(	(	-LRB-
cord-006860-a3b8hyyr	3250	15	'	'	``
cord-006860-a3b8hyyr	3250	16	PT	PT	NNP
cord-006860-a3b8hyyr	3250	17	15	15	CD
cord-006860-a3b8hyyr	3250	18	-	-	SYM
cord-006860-a3b8hyyr	3250	19	25	25	CD
cord-006860-a3b8hyyr	3250	20	see	see	NN
cord-006860-a3b8hyyr	3250	21	)	)	-RRB-
cord-006860-a3b8hyyr	3250	22	patients	patient	NNS
cord-006860-a3b8hyyr	3250	23	,	,	,
cord-006860-a3b8hyyr	3250	24	supplemented	supplement	VBN
cord-006860-a3b8hyyr	3250	25	with	with	IN
cord-006860-a3b8hyyr	3250	26	argatroban	argatroban	NNP
cord-006860-a3b8hyyr	3250	27	or	or	CC
cord-006860-a3b8hyyr	3250	28	hiredin	hiredin	NNP
cord-006860-a3b8hyyr	3250	29	did	do	VBD
cord-006860-a3b8hyyr	3250	30	not	not	RB
cord-006860-a3b8hyyr	3250	31	show	show	VB
cord-006860-a3b8hyyr	3250	32	any	any	DT
cord-006860-a3b8hyyr	3250	33	differences	difference	NNS
cord-006860-a3b8hyyr	3250	34	m	m	LS
cord-006860-a3b8hyyr	3250	35	the	the	DT
cord-006860-a3b8hyyr	3250	36	ECT	ECT	NNPS
cord-006860-a3b8hyyr	3250	37	.	.	.
cord-006860-a3b8hyyr	3251	1	A	a	DT
cord-006860-a3b8hyyr	3251	2	medified	medifie	VBN
cord-006860-a3b8hyyr	3251	3	ecarm	ecarm	NNP
cord-006860-a3b8hyyr	3251	4	ACT	ACT	NNP
cord-006860-a3b8hyyr	3251	5	comparable	comparable	JJ
cord-006860-a3b8hyyr	3251	6	to	to	IN
cord-006860-a3b8hyyr	3251	7	the	the	DT
cord-006860-a3b8hyyr	3251	8	celite	celite	NNP
cord-006860-a3b8hyyr	3251	9	ACT	ACT	NNP
cord-006860-a3b8hyyr	3251	10	has	have	VBZ
cord-006860-a3b8hyyr	3251	11	also	also	RB
cord-006860-a3b8hyyr	3251	12	been	be	VBN
cord-006860-a3b8hyyr	3251	13	developed	develop	VBN
cord-006860-a3b8hyyr	3251	14	.	.	.
cord-006860-a3b8hyyr	3252	1	Initial	initial	JJ
cord-006860-a3b8hyyr	3252	2	results	result	NNS
cord-006860-a3b8hyyr	3252	3	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	3252	4	that	that	IN
cord-006860-a3b8hyyr	3252	5	this	this	DT
cord-006860-a3b8hyyr	3252	6	test	test	NN
cord-006860-a3b8hyyr	3252	7	is	be	VBZ
cord-006860-a3b8hyyr	3252	8	not	not	RB
cord-006860-a3b8hyyr	3252	9	affected	affect	VBN
cord-006860-a3b8hyyr	3252	10	by	by	IN
cord-006860-a3b8hyyr	3252	11	aprotinin	aprotinin	NNS
cord-006860-a3b8hyyr	3252	12	,	,	,
cord-006860-a3b8hyyr	3252	13	heparin	heparin	NN
cord-006860-a3b8hyyr	3252	14	and	and	CC
cord-006860-a3b8hyyr	3252	15	reduction	reduction	NN
cord-006860-a3b8hyyr	3252	16	of	of	IN
cord-006860-a3b8hyyr	3252	17	the	the	DT
cord-006860-a3b8hyyr	3252	18	prothrorabin	prothrorabin	NNP
cord-006860-a3b8hyyr	3252	19	complexes	complex	NNS
cord-006860-a3b8hyyr	3252	20	in	in	IN
cord-006860-a3b8hyyr	3252	21	the	the	DT
cord-006860-a3b8hyyr	3252	22	INR	INR	NNP
cord-006860-a3b8hyyr	3252	23	range	range	NN
cord-006860-a3b8hyyr	3252	24	of	of	IN
cord-006860-a3b8hyyr	3252	25	1.5	1.5	CD
cord-006860-a3b8hyyr	3252	26	-3.0	-3.0	NNS
cord-006860-a3b8hyyr	3252	27	.	.	.
cord-006860-a3b8hyyr	3253	1	These	these	DT
cord-006860-a3b8hyyr	3253	2	results	result	NNS
cord-006860-a3b8hyyr	3253	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	3253	4	that	that	IN
cord-006860-a3b8hyyr	3253	5	ecarin	ecarin	NNP
cord-006860-a3b8hyyr	3253	6	based	base	VBN
cord-006860-a3b8hyyr	3253	7	clotting	clotting	NN
cord-006860-a3b8hyyr	3253	8	times	time	NNS
cord-006860-a3b8hyyr	3253	9	provide	provide	VB
cord-006860-a3b8hyyr	3253	10	SlX	SlX	NNP
cord-006860-a3b8hyyr	3253	11	~	~	NFP
cord-006860-a3b8hyyr	3253	12	etlie	etlie	NNP
cord-006860-a3b8hyyr	3253	13	~lts	~lts	NNP
cord-006860-a3b8hyyr	3253	14	of	of	IN
cord-006860-a3b8hyyr	3253	15	circulating	circulate	VBG
cord-006860-a3b8hyyr	3253	16	levels	level	NNS
cord-006860-a3b8hyyr	3253	17	of	of	IN
cord-006860-a3b8hyyr	3253	18	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3253	19	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3253	20	,	,	,
cord-006860-a3b8hyyr	3253	21	which	which	WDT
cord-006860-a3b8hyyr	3253	22	can	can	MD
cord-006860-a3b8hyyr	3253	23	provide	provide	VB
cord-006860-a3b8hyyr	3253	24	reliable	reliable	JJ
cord-006860-a3b8hyyr	3253	25	information	information	NN
cord-006860-a3b8hyyr	3253	26	to	to	TO
cord-006860-a3b8hyyr	3253	27	optimize	optimize	VB
cord-006860-a3b8hyyr	3253	28	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3253	29	safe(y	safe(y	NN
cord-006860-a3b8hyyr	3253	30	and	and	CC
cord-006860-a3b8hyyr	3253	31	efficacy	efficacy	NN
cord-006860-a3b8hyyr	3253	32	.	.	.
cord-006860-a3b8hyyr	3254	1	R	r	NN
cord-006860-a3b8hyyr	3254	2	-	-	:
cord-006860-a3b8hyyr	3254	3	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3254	4	is	be	VBZ
cord-006860-a3b8hyyr	3254	5	a	a	DT
cord-006860-a3b8hyyr	3254	6	highly	highly	RB
cord-006860-a3b8hyyr	3254	7	potent	potent	JJ
cord-006860-a3b8hyyr	3254	8	and	and	CC
cord-006860-a3b8hyyr	3254	9	selective	selective	JJ
cord-006860-a3b8hyyr	3254	10	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3254	11	of	of	IN
cord-006860-a3b8hyyr	3254	12	the	the	DT
cord-006860-a3b8hyyr	3254	13	serine	serine	NN
cord-006860-a3b8hyyr	3254	14	proteinase	proteinase	NN
cord-006860-a3b8hyyr	3254	15	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3254	16	.	.	.
cord-006860-a3b8hyyr	3255	1	After	after	IN
cord-006860-a3b8hyyr	3255	2	intravenous	intravenous	JJ
cord-006860-a3b8hyyr	3255	3	administration	administration	NN
cord-006860-a3b8hyyr	3255	4	,	,	,
cord-006860-a3b8hyyr	3255	5	r	r	NN
cord-006860-a3b8hyyr	3255	6	-	-	:
cord-006860-a3b8hyyr	3255	7	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3255	8	is	be	VBZ
cord-006860-a3b8hyyr	3255	9	eliminated	eliminate	VBN
cord-006860-a3b8hyyr	3255	10	exclusively	exclusively	RB
cord-006860-a3b8hyyr	3255	11	with	with	IN
cord-006860-a3b8hyyr	3255	12	the	the	DT
cord-006860-a3b8hyyr	3255	13	urine	urine	NN
cord-006860-a3b8hyyr	3255	14	.	.	.
cord-006860-a3b8hyyr	3256	1	Its	-PRON-	PRP$
cord-006860-a3b8hyyr	3256	2	plasma	plasma	NN
cord-006860-a3b8hyyr	3256	3	half	half	JJ
cord-006860-a3b8hyyr	3256	4	-	-	HYPH
cord-006860-a3b8hyyr	3256	5	life	life	NN
cord-006860-a3b8hyyr	3256	6	is	be	VBZ
cord-006860-a3b8hyyr	3256	7	very	very	RB
cord-006860-a3b8hyyr	3256	8	short	short	JJ
cord-006860-a3b8hyyr	3256	9	,	,	,
cord-006860-a3b8hyyr	3256	10	1	1	CD
cord-006860-a3b8hyyr	3256	11	-	-	HYPH
cord-006860-a3b8hyyr	3256	12	2h	2h	CD
cord-006860-a3b8hyyr	3256	13	.	.	.
cord-006860-a3b8hyyr	3257	1	PEG	peg	NN
cord-006860-a3b8hyyr	3257	2	-	-	HYPH
cord-006860-a3b8hyyr	3257	3	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3257	4	is	be	VBZ
cord-006860-a3b8hyyr	3257	5	a	a	DT
cord-006860-a3b8hyyr	3257	6	derivative	derivative	JJ
cord-006860-a3b8hyyr	3257	7	produced	produce	VBN
cord-006860-a3b8hyyr	3257	8	by	by	IN
cord-006860-a3b8hyyr	3257	9	coupling	couple	VBG
cord-006860-a3b8hyyr	3257	10	polyethylene	polyethylene	NN
cord-006860-a3b8hyyr	3257	11	glycol	glycol	NN
cord-006860-a3b8hyyr	3257	12	(	(	-LRB-
cord-006860-a3b8hyyr	3257	13	PEG	PEG	NNP
cord-006860-a3b8hyyr	3257	14	)	)	-RRB-
cord-006860-a3b8hyyr	3257	15	to	to	IN
cord-006860-a3b8hyyr	3257	16	a	a	DT
cord-006860-a3b8hyyr	3257	17	specially	specially	RB
cord-006860-a3b8hyyr	3257	18	designed	design	VBN
cord-006860-a3b8hyyr	3257	19	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	3257	20	hirudin	hirudin	NNP
cord-006860-a3b8hyyr	3257	21	mutein	mutein	NNP
cord-006860-a3b8hyyr	3257	22	.	.	.
cord-006860-a3b8hyyr	3258	1	PEG	peg	NN
cord-006860-a3b8hyyr	3258	2	-	-	HYPH
cord-006860-a3b8hyyr	3258	3	coupling	couple	VBG
cord-006860-a3b8hyyr	3258	4	results	result	NNS
cord-006860-a3b8hyyr	3258	5	in	in	IN
cord-006860-a3b8hyyr	3258	6	a	a	DT
cord-006860-a3b8hyyr	3258	7	considerable	considerable	JJ
cord-006860-a3b8hyyr	3258	8	prolongation	prolongation	NN
cord-006860-a3b8hyyr	3258	9	of	of	IN
cord-006860-a3b8hyyr	3258	10	the	the	DT
cord-006860-a3b8hyyr	3258	11	plasma	plasma	NN
cord-006860-a3b8hyyr	3258	12	half	half	JJ
cord-006860-a3b8hyyr	3258	13	-	-	HYPH
cord-006860-a3b8hyyr	3258	14	life	life	NN
cord-006860-a3b8hyyr	3258	15	of	of	IN
cord-006860-a3b8hyyr	3258	16	PEG	peg	NN
cord-006860-a3b8hyyr	3258	17	-	-	HYPH
cord-006860-a3b8hyyr	3258	18	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3258	19	,	,	,
cord-006860-a3b8hyyr	3258	20	compared	compare	VBN
cord-006860-a3b8hyyr	3258	21	to	to	IN
cord-006860-a3b8hyyr	3258	22	r	r	NN
cord-006860-a3b8hyyr	3258	23	-	-	:
cord-006860-a3b8hyyr	3258	24	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3258	25	.	.	.
cord-006860-a3b8hyyr	3259	1	After	after	IN
cord-006860-a3b8hyyr	3259	2	intravenous	intravenous	JJ
cord-006860-a3b8hyyr	3259	3	administration	administration	NN
cord-006860-a3b8hyyr	3259	4	of	of	IN
cord-006860-a3b8hyyr	3259	5	r	r	NNP
cord-006860-a3b8hyyr	3259	6	-	-	:
cord-006860-a3b8hyyr	3259	7	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3259	8	into	into	IN
cord-006860-a3b8hyyr	3259	9	rats	rat	NNS
cord-006860-a3b8hyyr	3259	10	,	,	,
cord-006860-a3b8hyyr	3259	11	a	a	DT
cord-006860-a3b8hyyr	3259	12	very	very	RB
cord-006860-a3b8hyyr	3259	13	small	small	JJ
cord-006860-a3b8hyyr	3259	14	amount	amount	NN
cord-006860-a3b8hyyr	3259	15	of	of	IN
cord-006860-a3b8hyyr	3259	16	,	,	,
cord-006860-a3b8hyyr	3259	17	,	,	,
cord-006860-a3b8hyyr	3259	18	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3259	19	-	-	HYPH
cord-006860-a3b8hyyr	3259	20	like	like	JJ
cord-006860-a3b8hyyr	3259	21	"	"	``
cord-006860-a3b8hyyr	3259	22	activity	activity	NN
cord-006860-a3b8hyyr	3259	23	(	(	-LRB-
cord-006860-a3b8hyyr	3259	24	2	2	CD
cord-006860-a3b8hyyr	3259	25	-4	-4	CD
cord-006860-a3b8hyyr	3259	26	%	%	NN
cord-006860-a3b8hyyr	3259	27	of	of	IN
cord-006860-a3b8hyyr	3259	28	applied	applied	JJ
cord-006860-a3b8hyyr	3259	29	activity	activity	NN
cord-006860-a3b8hyyr	3259	30	)	)	-RRB-
cord-006860-a3b8hyyr	3259	31	was	be	VBD
cord-006860-a3b8hyyr	3259	32	recovered	recover	VBN
cord-006860-a3b8hyyr	3259	33	in	in	IN
cord-006860-a3b8hyyr	3259	34	the	the	DT
cord-006860-a3b8hyyr	3259	35	urine	urine	NN
cord-006860-a3b8hyyr	3259	36	.	.	.
cord-006860-a3b8hyyr	3260	1	In	in	IN
cord-006860-a3b8hyyr	3260	2	contrast	contrast	NN
cord-006860-a3b8hyyr	3260	3	,	,	,
cord-006860-a3b8hyyr	3260	4	after	after	IN
cord-006860-a3b8hyyr	3260	5	PEG	peg	NN
cord-006860-a3b8hyyr	3260	6	-	-	HYPH
cord-006860-a3b8hyyr	3260	7	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3260	8	had	have	VBD
cord-006860-a3b8hyyr	3260	9	been	be	VBN
cord-006860-a3b8hyyr	3260	10	administered	administer	VBN
cord-006860-a3b8hyyr	3260	11	,	,	,
cord-006860-a3b8hyyr	3260	12	more	more	JJR
cord-006860-a3b8hyyr	3260	13	than	than	IN
cord-006860-a3b8hyyr	3260	14	30	30	CD
cord-006860-a3b8hyyr	3260	15	%	%	NN
cord-006860-a3b8hyyr	3260	16	of	of	IN
cord-006860-a3b8hyyr	3260	17	the	the	DT
cord-006860-a3b8hyyr	3260	18	applied	applied	JJ
cord-006860-a3b8hyyr	3260	19	activity	activity	NN
cord-006860-a3b8hyyr	3260	20	could	could	MD
cord-006860-a3b8hyyr	3260	21	be	be	VB
cord-006860-a3b8hyyr	3260	22	recovered	recover	VBN
cord-006860-a3b8hyyr	3260	23	in	in	IN
cord-006860-a3b8hyyr	3260	24	rat	rat	NN
cord-006860-a3b8hyyr	3260	25	urine	urine	NN
cord-006860-a3b8hyyr	3260	26	.	.	.
cord-006860-a3b8hyyr	3261	1	These	these	DT
cord-006860-a3b8hyyr	3261	2	results	result	NNS
cord-006860-a3b8hyyr	3261	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	3261	4	differences	difference	NNS
cord-006860-a3b8hyyr	3261	5	in	in	IN
cord-006860-a3b8hyyr	3261	6	the	the	DT
cord-006860-a3b8hyyr	3261	7	renal	renal	JJ
cord-006860-a3b8hyyr	3261	8	metabolism	metabolism	NN
cord-006860-a3b8hyyr	3261	9	of	of	IN
cord-006860-a3b8hyyr	3261	10	PEG	peg	NN
cord-006860-a3b8hyyr	3261	11	-	-	HYPH
cord-006860-a3b8hyyr	3261	12	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3261	13	and	and	CC
cord-006860-a3b8hyyr	3261	14	r	r	NN
cord-006860-a3b8hyyr	3261	15	-	-	NN
cord-006860-a3b8hyyr	3261	16	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3261	17	.	.	.
cord-006860-a3b8hyyr	3262	1	Within	within	IN
cord-006860-a3b8hyyr	3262	2	the	the	DT
cord-006860-a3b8hyyr	3262	3	scope	scope	NN
cord-006860-a3b8hyyr	3262	4	of	of	IN
cord-006860-a3b8hyyr	3262	5	pharmacokinetie	pharmacokinetie	NN
cord-006860-a3b8hyyr	3262	6	studies	study	NNS
cord-006860-a3b8hyyr	3262	7	in	in	IN
cord-006860-a3b8hyyr	3262	8	rats	rat	NNS
cord-006860-a3b8hyyr	3262	9	we	-PRON-	PRP
cord-006860-a3b8hyyr	3262	10	investigated	investigate	VBD
cord-006860-a3b8hyyr	3262	11	the	the	DT
cord-006860-a3b8hyyr	3262	12	appearance	appearance	NN
cord-006860-a3b8hyyr	3262	13	of	of	IN
cord-006860-a3b8hyyr	3262	14	biologically	biologically	RB
cord-006860-a3b8hyyr	3262	15	active	active	JJ
cord-006860-a3b8hyyr	3262	16	metabolites	metabolite	NNS
cord-006860-a3b8hyyr	3262	17	of	of	IN
cord-006860-a3b8hyyr	3262	18	PEG	peg	NN
cord-006860-a3b8hyyr	3262	19	-	-	HYPH
cord-006860-a3b8hyyr	3262	20	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3262	21	after	after	IN
cord-006860-a3b8hyyr	3262	22	kidney	kidney	NN
cord-006860-a3b8hyyr	3262	23	passage	passage	NN
cord-006860-a3b8hyyr	3262	24	in	in	IN
cord-006860-a3b8hyyr	3262	25	urine	urine	NN
cord-006860-a3b8hyyr	3262	26	.	.	.
cord-006860-a3b8hyyr	3263	1	Affinity	affinity	NN
cord-006860-a3b8hyyr	3263	2	chromatography	chromatography	NN
cord-006860-a3b8hyyr	3263	3	on	on	IN
cord-006860-a3b8hyyr	3263	4	immobilised	immobilised	JJ
cord-006860-a3b8hyyr	3263	5	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3263	6	was	be	VBD
cord-006860-a3b8hyyr	3263	7	used	use	VBN
cord-006860-a3b8hyyr	3263	8	as	as	IN
cord-006860-a3b8hyyr	3263	9	a	a	DT
cord-006860-a3b8hyyr	3263	10	quick	quick	JJ
cord-006860-a3b8hyyr	3263	11	and	and	CC
cord-006860-a3b8hyyr	3263	12	gentle	gentle	JJ
cord-006860-a3b8hyyr	3263	13	method	method	NN
cord-006860-a3b8hyyr	3263	14	in	in	IN
cord-006860-a3b8hyyr	3263	15	searching	search	VBG
cord-006860-a3b8hyyr	3263	16	for	for	IN
cord-006860-a3b8hyyr	3263	17	biologically	biologically	RB
cord-006860-a3b8hyyr	3263	18	active	active	JJ
cord-006860-a3b8hyyr	3263	19	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3263	20	metabolites	metabolite	NNS
cord-006860-a3b8hyyr	3263	21	in	in	IN
cord-006860-a3b8hyyr	3263	22	rat	rat	NN
cord-006860-a3b8hyyr	3263	23	urine	urine	NN
cord-006860-a3b8hyyr	3263	24	.	.	.
cord-006860-a3b8hyyr	3264	1	But	but	CC
cord-006860-a3b8hyyr	3264	2	it	-PRON-	PRP
cord-006860-a3b8hyyr	3264	3	had	have	VBD
cord-006860-a3b8hyyr	3264	4	to	to	TO
cord-006860-a3b8hyyr	3264	5	be	be	VB
cord-006860-a3b8hyyr	3264	6	completed	complete	VBN
cord-006860-a3b8hyyr	3264	7	by	by	IN
cord-006860-a3b8hyyr	3264	8	anion	anion	NN
cord-006860-a3b8hyyr	3264	9	-	-	HYPH
cord-006860-a3b8hyyr	3264	10	exchange	exchange	NN
cord-006860-a3b8hyyr	3264	11	and/or	and/or	CC
cord-006860-a3b8hyyr	3264	12	reversed	reverse	VBN
cord-006860-a3b8hyyr	3264	13	-	-	HYPH
cord-006860-a3b8hyyr	3264	14	phase	phase	NN
cord-006860-a3b8hyyr	3264	15	chromatography	chromatography	NN
cord-006860-a3b8hyyr	3264	16	to	to	TO
cord-006860-a3b8hyyr	3264	17	ensure	ensure	VB
cord-006860-a3b8hyyr	3264	18	that	that	IN
cord-006860-a3b8hyyr	3264	19	all	all	DT
cord-006860-a3b8hyyr	3264	20	active	active	JJ
cord-006860-a3b8hyyr	3264	21	metabolites	metabolite	NNS
cord-006860-a3b8hyyr	3264	22	were	be	VBD
cord-006860-a3b8hyyr	3264	23	detected	detect	VBN
cord-006860-a3b8hyyr	3264	24	.	.	.
cord-006860-a3b8hyyr	3265	1	The	the	DT
cord-006860-a3b8hyyr	3265	2	isolated	isolated	JJ
cord-006860-a3b8hyyr	3265	3	biologically	biologically	RB
cord-006860-a3b8hyyr	3265	4	active	active	JJ
cord-006860-a3b8hyyr	3265	5	metabolites	metabolite	NNS
cord-006860-a3b8hyyr	3265	6	were	be	VBD
cord-006860-a3b8hyyr	3265	7	purified	purify	VBN
cord-006860-a3b8hyyr	3265	8	by	by	IN
cord-006860-a3b8hyyr	3265	9	reversed	reverse	VBN
cord-006860-a3b8hyyr	3265	10	-	-	HYPH
cord-006860-a3b8hyyr	3265	11	phase	phase	NN
cord-006860-a3b8hyyr	3265	12	HPLC	HPLC	NNP
cord-006860-a3b8hyyr	3265	13	and	and	CC
cord-006860-a3b8hyyr	3265	14	were	be	VBD
cord-006860-a3b8hyyr	3265	15	biochemieally	biochemieally	RB
cord-006860-a3b8hyyr	3265	16	characterized	characterize	VBN
cord-006860-a3b8hyyr	3265	17	.	.	.
cord-006860-a3b8hyyr	3266	1	In	in	IN
cord-006860-a3b8hyyr	3266	2	previously	previously	RB
cord-006860-a3b8hyyr	3266	3	reported	report	VBN
cord-006860-a3b8hyyr	3266	4	studies	study	NNS
cord-006860-a3b8hyyr	3266	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	3266	6	found	find	VBD
cord-006860-a3b8hyyr	3266	7	a	a	DT
cord-006860-a3b8hyyr	3266	8	hlrud	hlrud	NNS
cord-006860-a3b8hyyr	3266	9	n	n	NN
cord-006860-a3b8hyyr	3266	10	derivative	derivative	JJ
cord-006860-a3b8hyyr	3266	11	consisting	consisting	NN
cord-006860-a3b8hyyr	3266	12	of	of	IN
cord-006860-a3b8hyyr	3266	13	the	the	DT
cord-006860-a3b8hyyr	3266	14	amino	amino	NN
cord-006860-a3b8hyyr	3266	15	acids	acid	NNS
cord-006860-a3b8hyyr	3266	16	1	1	CD
cord-006860-a3b8hyyr	3266	17	-	-	SYM
cord-006860-a3b8hyyr	3266	18	50	50	CD
cord-006860-a3b8hyyr	3266	19	as	as	IN
cord-006860-a3b8hyyr	3266	20	the	the	DT
cord-006860-a3b8hyyr	3266	21	main	main	JJ
cord-006860-a3b8hyyr	3266	22	metabolite	metabolite	NN
cord-006860-a3b8hyyr	3266	23	in	in	IN
cord-006860-a3b8hyyr	3266	24	rat	rat	NN
cord-006860-a3b8hyyr	3266	25	urine	urine	NN
cord-006860-a3b8hyyr	3266	26	following	follow	VBG
cord-006860-a3b8hyyr	3266	27	intravenous	intravenous	JJ
cord-006860-a3b8hyyr	3266	28	administration	administration	NN
cord-006860-a3b8hyyr	3266	29	of	of	IN
cord-006860-a3b8hyyr	3266	30	r	r	NNP
cord-006860-a3b8hyyr	3266	31	-	-	:
cord-006860-a3b8hyyr	3266	32	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3266	33	.	.	.
cord-006860-a3b8hyyr	3267	1	This	this	DT
cord-006860-a3b8hyyr	3267	2	metabolite	metabolite	NN
cord-006860-a3b8hyyr	3267	3	was	be	VBD
cord-006860-a3b8hyyr	3267	4	not	not	RB
cord-006860-a3b8hyyr	3267	5	detected	detect	VBN
cord-006860-a3b8hyyr	3267	6	in	in	IN
cord-006860-a3b8hyyr	3267	7	the	the	DT
cord-006860-a3b8hyyr	3267	8	urine	urine	NN
cord-006860-a3b8hyyr	3267	9	after	after	IN
cord-006860-a3b8hyyr	3267	10	administration	administration	NN
cord-006860-a3b8hyyr	3267	11	of	of	IN
cord-006860-a3b8hyyr	3267	12	PEG	PEG	NNP
cord-006860-a3b8hyyr	3267	13	-	-	HYPH
cord-006860-a3b8hyyr	3267	14	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3267	15	,	,	,
cord-006860-a3b8hyyr	3267	16	confirming	confirm	VBG
cord-006860-a3b8hyyr	3267	17	the	the	DT
cord-006860-a3b8hyyr	3267	18	suggestion	suggestion	NN
cord-006860-a3b8hyyr	3267	19	of	of	IN
cord-006860-a3b8hyyr	3267	20	a	a	DT
cord-006860-a3b8hyyr	3267	21	different	different	JJ
cord-006860-a3b8hyyr	3267	22	renal	renal	JJ
cord-006860-a3b8hyyr	3267	23	metabolism	metabolism	NN
cord-006860-a3b8hyyr	3267	24	.	.	.
cord-006860-a3b8hyyr	3268	1	Carrageenans	carrageenan	NNS
cord-006860-a3b8hyyr	3268	2	are	be	VBP
cord-006860-a3b8hyyr	3268	3	high	high	JJ
cord-006860-a3b8hyyr	3268	4	molecular	molecular	JJ
cord-006860-a3b8hyyr	3268	5	weight	weight	NN
cord-006860-a3b8hyyr	3268	6	sulfated	sulfate	VBN
cord-006860-a3b8hyyr	3268	7	polygalactans	polygalactan	NNS
cord-006860-a3b8hyyr	3268	8	of	of	IN
cord-006860-a3b8hyyr	3268	9	plant	plant	NN
cord-006860-a3b8hyyr	3268	10	origin	origin	NN
cord-006860-a3b8hyyr	3268	11	(	(	-LRB-
cord-006860-a3b8hyyr	3268	12	derived	derive	VBN
cord-006860-a3b8hyyr	3268	13	from	from	IN
cord-006860-a3b8hyyr	3268	14	red	red	JJ
cord-006860-a3b8hyyr	3268	15	algae	algae	NN
cord-006860-a3b8hyyr	3268	16	)	)	-RRB-
cord-006860-a3b8hyyr	3268	17	with	with	IN
cord-006860-a3b8hyyr	3268	18	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3268	19	properties	property	NNS
cord-006860-a3b8hyyr	3268	20	.	.	.
cord-006860-a3b8hyyr	3269	1	In	in	IN
cord-006860-a3b8hyyr	3269	2	previous	previous	JJ
cord-006860-a3b8hyyr	3269	3	studies	study	NNS
cord-006860-a3b8hyyr	3269	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	3269	5	investigated	investigate	VBD
cord-006860-a3b8hyyr	3269	6	the	the	DT
cord-006860-a3b8hyyr	3269	7	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3269	8	activity	activity	NN
cord-006860-a3b8hyyr	3269	9	of	of	IN
cord-006860-a3b8hyyr	3269	10	lambda	lambda	NN
cord-006860-a3b8hyyr	3269	11	-	-	HYPH
cord-006860-a3b8hyyr	3269	12	carrageenan	carrageenan	NN
cord-006860-a3b8hyyr	3269	13	,	,	,
cord-006860-a3b8hyyr	3269	14	a	a	DT
cord-006860-a3b8hyyr	3269	15	highly	highly	RB
cord-006860-a3b8hyyr	3269	16	sulfated	sulfated	JJ
cord-006860-a3b8hyyr	3269	17	type	type	NN
cord-006860-a3b8hyyr	3269	18	of	of	IN
cord-006860-a3b8hyyr	3269	19	carrageonans	carrageonan	NNS
cord-006860-a3b8hyyr	3269	20	.	.	.
cord-006860-a3b8hyyr	3270	1	Unlike	unlike	IN
cord-006860-a3b8hyyr	3270	2	heparin	heparin	NN
cord-006860-a3b8hyyr	3270	3	,	,	,
cord-006860-a3b8hyyr	3270	4	lambda	lambda	NN
cord-006860-a3b8hyyr	3270	5	-	-	HYPH
cord-006860-a3b8hyyr	3270	6	earrageenan	earrageenan	NNP
cord-006860-a3b8hyyr	3270	7	exerts	exert	VBZ
cord-006860-a3b8hyyr	3270	8	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3270	9	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3270	10	activity	activity	NN
cord-006860-a3b8hyyr	3270	11	primarily	primarily	RB
cord-006860-a3b8hyyr	3270	12	through	through	IN
cord-006860-a3b8hyyr	3270	13	direct	direct	JJ
cord-006860-a3b8hyyr	3270	14	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3270	15	of	of	IN
cord-006860-a3b8hyyr	3270	16	the	the	DT
cord-006860-a3b8hyyr	3270	17	serine	serine	NN
cord-006860-a3b8hyyr	3270	18	proteinase	proteinase	NN
cord-006860-a3b8hyyr	3270	19	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3270	20	.	.	.
cord-006860-a3b8hyyr	3271	1	Only	only	RB
cord-006860-a3b8hyyr	3271	2	a	a	DT
cord-006860-a3b8hyyr	3271	3	part	part	NN
cord-006860-a3b8hyyr	3271	4	of	of	IN
cord-006860-a3b8hyyr	3271	5	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3271	6	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3271	7	activity	activity	NN
cord-006860-a3b8hyyr	3271	8	is	be	VBZ
cord-006860-a3b8hyyr	3271	9	indirectly	indirectly	RB
cord-006860-a3b8hyyr	3271	10	mediated	mediate	VBN
cord-006860-a3b8hyyr	3271	11	through	through	IN
cord-006860-a3b8hyyr	3271	12	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3271	13	III	III	NNP
cord-006860-a3b8hyyr	3271	14	.	.	.
cord-006860-a3b8hyyr	3272	1	To	to	TO
cord-006860-a3b8hyyr	3272	2	investigate	investigate	VB
cord-006860-a3b8hyyr	3272	3	relations	relation	NNS
cord-006860-a3b8hyyr	3272	4	between	between	IN
cord-006860-a3b8hyyr	3272	5	molecular	molecular	JJ
cord-006860-a3b8hyyr	3272	6	weight	weight	NN
cord-006860-a3b8hyyr	3272	7	and	and	CC
cord-006860-a3b8hyyr	3272	8	biological	biological	JJ
cord-006860-a3b8hyyr	3272	9	activities	activity	NNS
cord-006860-a3b8hyyr	3272	10	,	,	,
cord-006860-a3b8hyyr	3272	11	tambda	tambda	NN
cord-006860-a3b8hyyr	3272	12	-	-	HYPH
cord-006860-a3b8hyyr	3272	13	carrageenan	carrageenan	NN
cord-006860-a3b8hyyr	3272	14	has	have	VBZ
cord-006860-a3b8hyyr	3272	15	been	be	VBN
cord-006860-a3b8hyyr	3272	16	hydrolysed	hydrolyse	VBN
cord-006860-a3b8hyyr	3272	17	and	and	CC
cord-006860-a3b8hyyr	3272	18	fractionated	fractionate	VBN
cord-006860-a3b8hyyr	3272	19	.	.	.
cord-006860-a3b8hyyr	3273	1	The	the	DT
cord-006860-a3b8hyyr	3273	2	molecular	molecular	JJ
cord-006860-a3b8hyyr	3273	3	weight	weight	NN
cord-006860-a3b8hyyr	3273	4	has	have	VBZ
cord-006860-a3b8hyyr	3273	5	been	be	VBN
cord-006860-a3b8hyyr	3273	6	determined	determine	VBN
cord-006860-a3b8hyyr	3273	7	with	with	IN
cord-006860-a3b8hyyr	3273	8	the	the	DT
cord-006860-a3b8hyyr	3273	9	aid	aid	NN
cord-006860-a3b8hyyr	3273	10	of	of	IN
cord-006860-a3b8hyyr	3273	11	size	size	NN
cord-006860-a3b8hyyr	3273	12	exclusion	exclusion	NN
cord-006860-a3b8hyyr	3273	13	HPLC	HPLC	NNP
cord-006860-a3b8hyyr	3273	14	using	use	VBG
cord-006860-a3b8hyyr	3273	15	dextrans	dextran	NNS
cord-006860-a3b8hyyr	3273	16	as	as	IN
cord-006860-a3b8hyyr	3273	17	molecular	molecular	JJ
cord-006860-a3b8hyyr	3273	18	weight	weight	NN
cord-006860-a3b8hyyr	3273	19	standards	standard	NNS
cord-006860-a3b8hyyr	3273	20	.	.	.
cord-006860-a3b8hyyr	3274	1	The	the	DT
cord-006860-a3b8hyyr	3274	2	degree	degree	NN
cord-006860-a3b8hyyr	3274	3	of	of	IN
cord-006860-a3b8hyyr	3274	4	sulfation	sulfation	NN
cord-006860-a3b8hyyr	3274	5	has	have	VBZ
cord-006860-a3b8hyyr	3274	6	been	be	VBN
cord-006860-a3b8hyyr	3274	7	determined	determine	VBN
cord-006860-a3b8hyyr	3274	8	by	by	IN
cord-006860-a3b8hyyr	3274	9	anion	anion	NN
cord-006860-a3b8hyyr	3274	10	-	-	HYPH
cord-006860-a3b8hyyr	3274	11	exchange	exchange	NN
cord-006860-a3b8hyyr	3274	12	HPLC	HPLC	NNP
cord-006860-a3b8hyyr	3274	13	.	.	.
cord-006860-a3b8hyyr	3275	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3275	2	have	have	VBP
cord-006860-a3b8hyyr	3275	3	obtained	obtain	VBN
cord-006860-a3b8hyyr	3275	4	low	low	JJ
cord-006860-a3b8hyyr	3275	5	molecular	molecular	JJ
cord-006860-a3b8hyyr	3275	6	weight	weight	NN
cord-006860-a3b8hyyr	3275	7	lambdaearrageenans	lambdaearrageenan	NNS
cord-006860-a3b8hyyr	3275	8	ranging	range	VBG
cord-006860-a3b8hyyr	3275	9	from	from	IN
cord-006860-a3b8hyyr	3275	10	10,000	10,000	CD
cord-006860-a3b8hyyr	3275	11	dalton	dalton	NNP
cord-006860-a3b8hyyr	3275	12	to	to	IN
cord-006860-a3b8hyyr	3275	13	100,000	100,000	CD
cord-006860-a3b8hyyr	3275	14	dalton	dalton	NNP
cord-006860-a3b8hyyr	3275	15	with	with	IN
cord-006860-a3b8hyyr	3275	16	degrees	degree	NNS
cord-006860-a3b8hyyr	3275	17	of	of	IN
cord-006860-a3b8hyyr	3275	18	sulfation	sulfation	NN
cord-006860-a3b8hyyr	3275	19	of	of	IN
cord-006860-a3b8hyyr	3275	20	13	13	CD
cord-006860-a3b8hyyr	3275	21	-17	-17	CD
cord-006860-a3b8hyyr	3275	22	%	%	NN
cord-006860-a3b8hyyr	3275	23	and	and	CC
cord-006860-a3b8hyyr	3275	24	33	33	CD
cord-006860-a3b8hyyr	3275	25	-38	-38	CD
cord-006860-a3b8hyyr	3275	26	%	%	NN
cord-006860-a3b8hyyr	3275	27	.	.	.
cord-006860-a3b8hyyr	3276	1	The	the	DT
cord-006860-a3b8hyyr	3276	2	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3276	3	and	and	CC
cord-006860-a3b8hyyr	3276	4	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3276	5	activity	activity	NN
cord-006860-a3b8hyyr	3276	6	of	of	IN
cord-006860-a3b8hyyr	3276	7	low	low	JJ
cord-006860-a3b8hyyr	3276	8	molecular	molecular	JJ
cord-006860-a3b8hyyr	3276	9	weight	weight	NN
cord-006860-a3b8hyyr	3276	10	carrageenans	carrageenan	NNS
cord-006860-a3b8hyyr	3276	11	have	have	VBP
cord-006860-a3b8hyyr	3276	12	been	be	VBN
cord-006860-a3b8hyyr	3276	13	determined	determine	VBN
cord-006860-a3b8hyyr	3276	14	using	use	VBG
cord-006860-a3b8hyyr	3276	15	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3276	16	assays	assay	NNS
cord-006860-a3b8hyyr	3276	17	and	and	CC
cord-006860-a3b8hyyr	3276	18	purified	purify	VBN
cord-006860-a3b8hyyr	3276	19	systems	system	NNS
cord-006860-a3b8hyyr	3276	20	,	,	,
cord-006860-a3b8hyyr	3276	21	and	and	CC
cord-006860-a3b8hyyr	3276	22	we	-PRON-	PRP
cord-006860-a3b8hyyr	3276	23	have	have	VBP
cord-006860-a3b8hyyr	3276	24	compared	compare	VBN
cord-006860-a3b8hyyr	3276	25	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3276	26	activities	activity	NNS
cord-006860-a3b8hyyr	3276	27	with	with	IN
cord-006860-a3b8hyyr	3276	28	those	those	DT
cord-006860-a3b8hyyr	3276	29	of	of	IN
cord-006860-a3b8hyyr	3276	30	heparin	heparin	NN
cord-006860-a3b8hyyr	3276	31	and	and	CC
cord-006860-a3b8hyyr	3276	32	other	other	JJ
cord-006860-a3b8hyyr	3276	33	sulfated	sulfated	JJ
cord-006860-a3b8hyyr	3276	34	polysaecharides	polysaecharide	NNS
cord-006860-a3b8hyyr	3276	35	.	.	.
cord-006860-a3b8hyyr	3277	1	Further	further	RB
cord-006860-a3b8hyyr	3277	2	,	,	,
cord-006860-a3b8hyyr	3277	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	3277	4	have	have	VBP
cord-006860-a3b8hyyr	3277	5	investigated	investigate	VBN
cord-006860-a3b8hyyr	3277	6	the	the	DT
cord-006860-a3b8hyyr	3277	7	ability	ability	NN
cord-006860-a3b8hyyr	3277	8	of	of	IN
cord-006860-a3b8hyyr	3277	9	lambda	lambda	NN
cord-006860-a3b8hyyr	3277	10	-	-	HYPH
cord-006860-a3b8hyyr	3277	11	carrageenan	carrageenan	NN
cord-006860-a3b8hyyr	3277	12	and	and	CC
cord-006860-a3b8hyyr	3277	13	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3277	14	low	low	JJ
cord-006860-a3b8hyyr	3277	15	molecular	molecular	JJ
cord-006860-a3b8hyyr	3277	16	weight	weight	NN
cord-006860-a3b8hyyr	3277	17	derivatives	derivative	NNS
cord-006860-a3b8hyyr	3277	18	to	to	TO
cord-006860-a3b8hyyr	3277	19	inhibit	inhibit	VB
cord-006860-a3b8hyyr	3277	20	the	the	DT
cord-006860-a3b8hyyr	3277	21	activity	activity	NN
cord-006860-a3b8hyyr	3277	22	of	of	IN
cord-006860-a3b8hyyr	3277	23	human	human	JJ
cord-006860-a3b8hyyr	3277	24	blood	blood	NN
cord-006860-a3b8hyyr	3277	25	phagocytes	phagocyte	NNS
cord-006860-a3b8hyyr	3277	26	.	.	.
cord-006860-a3b8hyyr	3278	1	The	the	DT
cord-006860-a3b8hyyr	3278	2	activity	activity	NN
cord-006860-a3b8hyyr	3278	3	has	have	VBZ
cord-006860-a3b8hyyr	3278	4	been	be	VBN
cord-006860-a3b8hyyr	3278	5	determined	determine	VBN
cord-006860-a3b8hyyr	3278	6	by	by	IN
cord-006860-a3b8hyyr	3278	7	measuring	measure	VBG
cord-006860-a3b8hyyr	3278	8	the	the	DT
cord-006860-a3b8hyyr	3278	9	cellular	cellular	JJ
cord-006860-a3b8hyyr	3278	10	chemiluminescence	chemiluminescence	NN
cord-006860-a3b8hyyr	3278	11	in	in	IN
cord-006860-a3b8hyyr	3278	12	a	a	DT
cord-006860-a3b8hyyr	3278	13	mieroplate	mieroplate	NNP
cord-006860-a3b8hyyr	3278	14	himinometer	himinometer	NN
cord-006860-a3b8hyyr	3278	15	using	use	VBG
cord-006860-a3b8hyyr	3278	16	a	a	DT
cord-006860-a3b8hyyr	3278	17	himinol	himinol	NN
cord-006860-a3b8hyyr	3278	18	-	-	HYPH
cord-006860-a3b8hyyr	3278	19	dependent	dependent	JJ
cord-006860-a3b8hyyr	3278	20	assay	assay	NN
cord-006860-a3b8hyyr	3278	21	and	and	CC
cord-006860-a3b8hyyr	3278	22	zymosan	zymosan	NNP
cord-006860-a3b8hyyr	3278	23	as	as	IN
cord-006860-a3b8hyyr	3278	24	phagocytosis	phagocytosis	NN
cord-006860-a3b8hyyr	3278	25	activating	activate	VBG
cord-006860-a3b8hyyr	3278	26	agent	agent	NN
cord-006860-a3b8hyyr	3278	27	.	.	.
cord-006860-a3b8hyyr	3279	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3279	2	have	have	VBP
cord-006860-a3b8hyyr	3279	3	used	use	VBN
cord-006860-a3b8hyyr	3279	4	an	an	DT
cord-006860-a3b8hyyr	3279	5	assay	assay	NN
cord-006860-a3b8hyyr	3279	6	in	in	IN
cord-006860-a3b8hyyr	3279	7	human	human	JJ
cord-006860-a3b8hyyr	3279	8	whole	whole	JJ
cord-006860-a3b8hyyr	3279	9	blood	blood	NN
cord-006860-a3b8hyyr	3279	10	and	and	CC
cord-006860-a3b8hyyr	3279	11	assays	assay	NNS
cord-006860-a3b8hyyr	3279	12	with	with	IN
cord-006860-a3b8hyyr	3279	13	isolated	isolate	VBN
cord-006860-a3b8hyyr	3279	14	human	human	JJ
cord-006860-a3b8hyyr	3279	15	mononuclear	mononuclear	NN
cord-006860-a3b8hyyr	3279	16	and	and	CC
cord-006860-a3b8hyyr	3279	17	polymorphnuclear	polymorphnuclear	NN
cord-006860-a3b8hyyr	3279	18	cells	cell	NNS
cord-006860-a3b8hyyr	3279	19	.	.	.
cord-006860-a3b8hyyr	3280	1	The	the	DT
cord-006860-a3b8hyyr	3280	2	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3280	3	activity	activity	NN
cord-006860-a3b8hyyr	3280	4	and	and	CC
cord-006860-a3b8hyyr	3280	5	also	also	RB
cord-006860-a3b8hyyr	3280	6	the	the	DT
cord-006860-a3b8hyyr	3280	7	ability	ability	NN
cord-006860-a3b8hyyr	3280	8	of	of	IN
cord-006860-a3b8hyyr	3280	9	carrageenans	carrageenan	NNS
cord-006860-a3b8hyyr	3280	10	to	to	TO
cord-006860-a3b8hyyr	3280	11	inhibit	inhibit	VB
cord-006860-a3b8hyyr	3280	12	the	the	DT
cord-006860-a3b8hyyr	3280	13	activity	activity	NN
cord-006860-a3b8hyyr	3280	14	of	of	IN
cord-006860-a3b8hyyr	3280	15	human	human	JJ
cord-006860-a3b8hyyr	3280	16	macrophages	macrophage	NNS
cord-006860-a3b8hyyr	3280	17	decrease	decrease	VBP
cord-006860-a3b8hyyr	3280	18	with	with	IN
cord-006860-a3b8hyyr	3280	19	decreasing	decrease	VBG
cord-006860-a3b8hyyr	3280	20	molecular	molecular	JJ
cord-006860-a3b8hyyr	3280	21	weight	weight	NN
cord-006860-a3b8hyyr	3280	22	and	and	CC
cord-006860-a3b8hyyr	3280	23	decreasing	decrease	VBG
cord-006860-a3b8hyyr	3280	24	degree	degree	NN
cord-006860-a3b8hyyr	3280	25	of	of	IN
cord-006860-a3b8hyyr	3280	26	sulfation	sulfation	NN
cord-006860-a3b8hyyr	3280	27	.	.	.
cord-006860-a3b8hyyr	3281	1	The	the	DT
cord-006860-a3b8hyyr	3281	2	natural	natural	JJ
cord-006860-a3b8hyyr	3281	3	ocouring	ocouring	NN
cord-006860-a3b8hyyr	3281	4	,	,	,
cord-006860-a3b8hyyr	3281	5	yellow	yellow	JJ
cord-006860-a3b8hyyr	3281	6	pigment	pigment	NN
cord-006860-a3b8hyyr	3281	7	curcumin	curcumin	NN
cord-006860-a3b8hyyr	3281	8	is	be	VBZ
cord-006860-a3b8hyyr	3281	9	the	the	DT
cord-006860-a3b8hyyr	3281	10	major	major	JJ
cord-006860-a3b8hyyr	3281	11	component	component	NN
cord-006860-a3b8hyyr	3281	12	of	of	IN
cord-006860-a3b8hyyr	3281	13	tumeric	tumeric	NN
cord-006860-a3b8hyyr	3281	14	and	and	CC
cord-006860-a3b8hyyr	3281	15	is	be	VBZ
cord-006860-a3b8hyyr	3281	16	commonly	commonly	RB
cord-006860-a3b8hyyr	3281	17	used	use	VBN
cord-006860-a3b8hyyr	3281	18	as	as	IN
cord-006860-a3b8hyyr	3281	19	a	a	DT
cord-006860-a3b8hyyr	3281	20	spice	spice	NN
cord-006860-a3b8hyyr	3281	21	and	and	CC
cord-006860-a3b8hyyr	3281	22	food	food	NN
cord-006860-a3b8hyyr	3281	23	-	-	HYPH
cord-006860-a3b8hyyr	3281	24	coloring	color	VBG
cord-006860-a3b8hyyr	3281	25	agent	agent	NN
cord-006860-a3b8hyyr	3281	26	.	.	.
cord-006860-a3b8hyyr	3282	1	Since	since	IN
cord-006860-a3b8hyyr	3282	2	curcumin	curcumin	NN
cord-006860-a3b8hyyr	3282	3	has	have	VBZ
cord-006860-a3b8hyyr	3282	4	been	be	VBN
cord-006860-a3b8hyyr	3282	5	reported	report	VBN
cord-006860-a3b8hyyr	3282	6	to	to	TO
cord-006860-a3b8hyyr	3282	7	have	have	VB
cord-006860-a3b8hyyr	3282	8	anti	anti	JJ
cord-006860-a3b8hyyr	3282	9	-	-	JJ
cord-006860-a3b8hyyr	3282	10	tumorpromoting	tumorpromoting	JJ
cord-006860-a3b8hyyr	3282	11	,	,	,
cord-006860-a3b8hyyr	3282	12	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	3282	13	and	and	CC
cord-006860-a3b8hyyr	3282	14	anti	anti	JJ
cord-006860-a3b8hyyr	3282	15	-	-	JJ
cord-006860-a3b8hyyr	3282	16	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	3282	17	properties	property	NNS
cord-006860-a3b8hyyr	3282	18	,	,	,
cord-006860-a3b8hyyr	3282	19	we	-PRON-	PRP
cord-006860-a3b8hyyr	3282	20	studied	study	VBD
cord-006860-a3b8hyyr	3282	21	,	,	,
cord-006860-a3b8hyyr	3282	22	whether	whether	IN
cord-006860-a3b8hyyr	3282	23	curcumin	curcumin	NN
cord-006860-a3b8hyyr	3282	24	acts	act	VBZ
cord-006860-a3b8hyyr	3282	25	on	on	IN
cord-006860-a3b8hyyr	3282	26	the	the	DT
cord-006860-a3b8hyyr	3282	27	transcription	transcription	NN
cord-006860-a3b8hyyr	3282	28	factors	factor	NNS
cord-006860-a3b8hyyr	3282	29	AP	AP	NNP
cord-006860-a3b8hyyr	3282	30	-	-	HYPH
cord-006860-a3b8hyyr	3282	31	l(Jun	l(Jun	NNP
cord-006860-a3b8hyyr	3282	32	/	/	SYM
cord-006860-a3b8hyyr	3282	33	Fos	Fos	NNP
cord-006860-a3b8hyyr	3282	34	)	)	-RRB-
cord-006860-a3b8hyyr	3282	35	and	and	CC
cord-006860-a3b8hyyr	3282	36	NF-~:B	NF-~:B	NNP
cord-006860-a3b8hyyr	3282	37	in	in	IN
cord-006860-a3b8hyyr	3282	38	cultured	cultured	JJ
cord-006860-a3b8hyyr	3282	39	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	3282	40	cells	cell	NNS
cord-006860-a3b8hyyr	3282	41	(	(	-LRB-
cord-006860-a3b8hyyr	3282	42	EC	EC	NNP
cord-006860-a3b8hyyr	3282	43	)	)	-RRB-
cord-006860-a3b8hyyr	3282	44	.	.	.
cord-006860-a3b8hyyr	3283	1	When	when	WRB
cord-006860-a3b8hyyr	3283	2	EC	EC	NNP
cord-006860-a3b8hyyr	3283	3	were	be	VBD
cord-006860-a3b8hyyr	3283	4	cultured	culture	VBN
cord-006860-a3b8hyyr	3283	5	in	in	IN
cord-006860-a3b8hyyr	3283	6	the	the	DT
cord-006860-a3b8hyyr	3283	7	presence	presence	NN
cord-006860-a3b8hyyr	3283	8	of	of	IN
cord-006860-a3b8hyyr	3283	9	curcumin	curcumin	NN
cord-006860-a3b8hyyr	3283	10	,	,	,
cord-006860-a3b8hyyr	3283	11	Electrophoretic	Electrophoretic	NNP
cord-006860-a3b8hyyr	3283	12	Mobility	Mobility	NNP
cord-006860-a3b8hyyr	3283	13	Shift	Shift	NNP
cord-006860-a3b8hyyr	3283	14	Assays	Assays	NNP
cord-006860-a3b8hyyr	3283	15	(	(	-LRB-
cord-006860-a3b8hyyr	3283	16	EMSA	EMSA	NNP
cord-006860-a3b8hyyr	3283	17	)	)	-RRB-
cord-006860-a3b8hyyr	3283	18	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	3283	19	,	,	,
cord-006860-a3b8hyyr	3283	20	that	that	IN
cord-006860-a3b8hyyr	3283	21	binding	binding	NN
cord-006860-a3b8hyyr	3283	22	of	of	IN
cord-006860-a3b8hyyr	3283	23	endogenous	endogenous	JJ
cord-006860-a3b8hyyr	3283	24	AP-1	AP-1	NNP
cord-006860-a3b8hyyr	3283	25	to	to	IN
cord-006860-a3b8hyyr	3283	26	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3283	27	DNA	dna	NN
cord-006860-a3b8hyyr	3283	28	recognition	recognition	NN
cord-006860-a3b8hyyr	3283	29	motif	motif	NN
cord-006860-a3b8hyyr	3283	30	was	be	VBD
cord-006860-a3b8hyyr	3283	31	suppressed	suppress	VBN
cord-006860-a3b8hyyr	3283	32	.	.	.
cord-006860-a3b8hyyr	3284	1	Inhibition	inhibition	NN
cord-006860-a3b8hyyr	3284	2	was	be	VBD
cord-006860-a3b8hyyr	3284	3	due	due	JJ
cord-006860-a3b8hyyr	3284	4	to	to	IN
cord-006860-a3b8hyyr	3284	5	direct	direct	JJ
cord-006860-a3b8hyyr	3284	6	interactions	interaction	NNS
cord-006860-a3b8hyyr	3284	7	of	of	IN
cord-006860-a3b8hyyr	3284	8	curcumin	curcumin	NN
cord-006860-a3b8hyyr	3284	9	with	with	IN
cord-006860-a3b8hyyr	3284	10	the	the	DT
cord-006860-a3b8hyyr	3284	11	DNA	dna	NN
cord-006860-a3b8hyyr	3284	12	-	-	HYPH
cord-006860-a3b8hyyr	3284	13	binding	bind	VBG
cord-006860-a3b8hyyr	3284	14	motif	motif	NN
cord-006860-a3b8hyyr	3284	15	for	for	IN
cord-006860-a3b8hyyr	3284	16	AP	AP	NNP
cord-006860-a3b8hyyr	3284	17	-	-	HYPH
cord-006860-a3b8hyyr	3284	18	I.	I.	NNP
cord-006860-a3b8hyyr	3284	19	Enhanced	Enhanced	NNP
cord-006860-a3b8hyyr	3284	20	AP-1	AP-1	NNP
cord-006860-a3b8hyyr	3284	21	binding	bind	VBG
cord-006860-a3b8hyyr	3284	22	,	,	,
cord-006860-a3b8hyyr	3284	23	induced	induce	VBN
cord-006860-a3b8hyyr	3284	24	after	after	IN
cord-006860-a3b8hyyr	3284	25	TNFa	TNFa	NNP
cord-006860-a3b8hyyr	3284	26	stimulation	stimulation	NN
cord-006860-a3b8hyyr	3284	27	of	of	IN
cord-006860-a3b8hyyr	3284	28	EC	EC	NNP
cord-006860-a3b8hyyr	3284	29	,	,	,
cord-006860-a3b8hyyr	3284	30	was	be	VBD
cord-006860-a3b8hyyr	3284	31	decreased	decrease	VBN
cord-006860-a3b8hyyr	3284	32	in	in	IN
cord-006860-a3b8hyyr	3284	33	cells	cell	NNS
cord-006860-a3b8hyyr	3284	34	pretreated	pretreate	VBN
cord-006860-a3b8hyyr	3284	35	with	with	IN
cord-006860-a3b8hyyr	3284	36	curcumin	curcumin	NN
cord-006860-a3b8hyyr	3284	37	.	.	.
cord-006860-a3b8hyyr	3285	1	This	this	DT
cord-006860-a3b8hyyr	3285	2	resulted	result	VBD
cord-006860-a3b8hyyr	3285	3	in	in	IN
cord-006860-a3b8hyyr	3285	4	reduced	reduce	VBN
cord-006860-a3b8hyyr	3285	5	transcription	transcription	NN
cord-006860-a3b8hyyr	3285	6	and	and	CC
cord-006860-a3b8hyyr	3285	7	expression	expression	NN
cord-006860-a3b8hyyr	3285	8	of	of	IN
cord-006860-a3b8hyyr	3285	9	Tissue	Tissue	NNP
cord-006860-a3b8hyyr	3285	10	Factor	Factor	NNP
cord-006860-a3b8hyyr	3285	11	,	,	,
cord-006860-a3b8hyyr	3285	12	known	know	VBN
cord-006860-a3b8hyyr	3285	13	to	to	TO
cord-006860-a3b8hyyr	3285	14	be	be	VB
cord-006860-a3b8hyyr	3285	15	controlled	control	VBN
cord-006860-a3b8hyyr	3285	16	by	by	IN
cord-006860-a3b8hyyr	3285	17	AP	AP	NNP
cord-006860-a3b8hyyr	3285	18	-	-	HYPH
cord-006860-a3b8hyyr	3285	19	f	f	NNP
cord-006860-a3b8hyyr	3285	20	and	and	CC
cord-006860-a3b8hyyr	3285	21	NF-~B.	NF-~B.	NNP
cord-006860-a3b8hyyr	3285	22	Nuclear	Nuclear	NNP
cord-006860-a3b8hyyr	3285	23	Run	Run	NNP
cord-006860-a3b8hyyr	3285	24	on	on	IN
cord-006860-a3b8hyyr	3285	25	assays	assay	NNS
cord-006860-a3b8hyyr	3285	26	proofed	proof	VBN
cord-006860-a3b8hyyr	3285	27	,	,	,
cord-006860-a3b8hyyr	3285	28	that	that	DT
cord-006860-a3b8hyyr	3285	29	curcumin	curcumin	NN
cord-006860-a3b8hyyr	3285	30	directly	directly	RB
cord-006860-a3b8hyyr	3285	31	reduced	reduce	VBD
cord-006860-a3b8hyyr	3285	32	the	the	DT
cord-006860-a3b8hyyr	3285	33	TNFa	TNFa	NNS
cord-006860-a3b8hyyr	3285	34	mediated	mediate	VBD
cord-006860-a3b8hyyr	3285	35	transcription	transcription	NN
cord-006860-a3b8hyyr	3285	36	of	of	IN
cord-006860-a3b8hyyr	3285	37	genes	gene	NNS
cord-006860-a3b8hyyr	3285	38	,	,	,
cord-006860-a3b8hyyr	3285	39	regulated	regulate	VBN
cord-006860-a3b8hyyr	3285	40	by	by	IN
cord-006860-a3b8hyyr	3285	41	AP-1	AP-1	NNP
cord-006860-a3b8hyyr	3285	42	,	,	,
cord-006860-a3b8hyyr	3285	43	as	as	IN
cord-006860-a3b8hyyr	3285	44	TF	TF	NNP
cord-006860-a3b8hyyr	3285	45	,	,	,
cord-006860-a3b8hyyr	3285	46	endothelin-1	endothelin-1	NNP
cord-006860-a3b8hyyr	3285	47	and	and	CC
cord-006860-a3b8hyyr	3285	48	c	c	NNP
cord-006860-a3b8hyyr	3285	49	-	-	:
cord-006860-a3b8hyyr	3285	50	Jun	Jun	NNP
cord-006860-a3b8hyyr	3285	51	.	.	.
cord-006860-a3b8hyyr	3286	1	Thus	thus	RB
cord-006860-a3b8hyyr	3286	2	,	,	,
cord-006860-a3b8hyyr	3286	3	curcumin	curcumin	NN
cord-006860-a3b8hyyr	3286	4	did	do	VBD
cord-006860-a3b8hyyr	3286	5	not	not	RB
cord-006860-a3b8hyyr	3286	6	only	only	RB
cord-006860-a3b8hyyr	3286	7	suppress	suppress	VB
cord-006860-a3b8hyyr	3286	8	APl(Jun	APl(Jun	NNS
cord-006860-a3b8hyyr	3286	9	/	/	SYM
cord-006860-a3b8hyyr	3286	10	Fos)-binding	fos)-binding	NN
cord-006860-a3b8hyyr	3286	11	,	,	,
cord-006860-a3b8hyyr	3286	12	but	but	CC
cord-006860-a3b8hyyr	3286	13	also	also	RB
cord-006860-a3b8hyyr	3286	14	inhibited	inhibited	JJ
cord-006860-a3b8hyyr	3286	15	TNFa	TNFa	NNS
cord-006860-a3b8hyyr	3286	16	induced	induce	VBD
cord-006860-a3b8hyyr	3286	17	Jun	Jun	NNP
cord-006860-a3b8hyyr	3286	18	transcription	transcription	NN
cord-006860-a3b8hyyr	3286	19	,	,	,
cord-006860-a3b8hyyr	3286	20	Transient	transient	JJ
cord-006860-a3b8hyyr	3286	21	transfections	transfection	NNS
cord-006860-a3b8hyyr	3286	22	with	with	IN
cord-006860-a3b8hyyr	3286	23	Tissue	tissue	NN
cord-006860-a3b8hyyr	3286	24	Factor	Factor	NNP
cord-006860-a3b8hyyr	3286	25	promotor	promotor	NN
cord-006860-a3b8hyyr	3286	26	plasmids	plasmid	NNS
cord-006860-a3b8hyyr	3286	27	confirmed	confirm	VBD
cord-006860-a3b8hyyr	3286	28	,	,	,
cord-006860-a3b8hyyr	3286	29	that	that	DT
cord-006860-a3b8hyyr	3286	30	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3286	31	by	by	IN
cord-006860-a3b8hyyr	3286	32	curcumin	curcumin	NN
cord-006860-a3b8hyyr	3286	33	was	be	VBD
cord-006860-a3b8hyyr	3286	34	dependent	dependent	JJ
cord-006860-a3b8hyyr	3286	35	on	on	IN
cord-006860-a3b8hyyr	3286	36	intact	intact	JJ
cord-006860-a3b8hyyr	3287	1	AP	AP	NNP
cord-006860-a3b8hyyr	3287	2	-	-	HYPH
cord-006860-a3b8hyyr	3287	3	I	-PRON-	PRP
cord-006860-a3b8hyyr	3287	4	sites	site	NNS
cord-006860-a3b8hyyr	3287	5	.	.	.
cord-006860-a3b8hyyr	3288	1	Beside	beside	IN
cord-006860-a3b8hyyr	3288	2	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3288	3	effect	effect	NN
cord-006860-a3b8hyyr	3288	4	on	on	IN
cord-006860-a3b8hyyr	3288	5	AP	AP	NNP
cord-006860-a3b8hyyr	3288	6	-	-	HYPH
cord-006860-a3b8hyyr	3288	7	l	l	NN
cord-006860-a3b8hyyr	3288	8	-	-	HYPH
cord-006860-a3b8hyyr	3288	9	binding	binding	JJ
cord-006860-a3b8hyyr	3288	10	,	,	,
cord-006860-a3b8hyyr	3288	11	curcumin	curcumin	NN
cord-006860-a3b8hyyr	3288	12	reduced	reduce	VBD
cord-006860-a3b8hyyr	3288	13	the	the	DT
cord-006860-a3b8hyyr	3288	14	radical	radical	JJ
cord-006860-a3b8hyyr	3288	15	dependent	dependent	JJ
cord-006860-a3b8hyyr	3288	16	activation	activation	NN
cord-006860-a3b8hyyr	3288	17	of	of	IN
cord-006860-a3b8hyyr	3288	18	NF	NF	NNP
cord-006860-a3b8hyyr	3288	19	-	-	HYPH
cord-006860-a3b8hyyr	3288	20	KB	KB	NNP
cord-006860-a3b8hyyr	3288	21	due	due	IN
cord-006860-a3b8hyyr	3288	22	to	to	IN
cord-006860-a3b8hyyr	3288	23	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3288	24	antioxidant	antioxidant	JJ
cord-006860-a3b8hyyr	3288	25	properties	property	NNS
cord-006860-a3b8hyyr	3288	26	,	,	,
cord-006860-a3b8hyyr	3288	27	however	however	RB
cord-006860-a3b8hyyr	3288	28	,	,	,
cord-006860-a3b8hyyr	3288	29	this	this	DT
cord-006860-a3b8hyyr	3288	30	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3288	31	was	be	VBD
cord-006860-a3b8hyyr	3288	32	indirect	indirect	JJ
cord-006860-a3b8hyyr	3288	33	and	and	CC
cord-006860-a3b8hyyr	3288	34	less	less	RBR
cord-006860-a3b8hyyr	3288	35	prominent	prominent	JJ
cord-006860-a3b8hyyr	3288	36	.	.	.
cord-006860-a3b8hyyr	3289	1	The	the	DT
cord-006860-a3b8hyyr	3289	2	relevance	relevance	NN
cord-006860-a3b8hyyr	3289	3	of	of	IN
cord-006860-a3b8hyyr	3289	4	the	the	DT
cord-006860-a3b8hyyr	3289	5	in	in	FW
cord-006860-a3b8hyyr	3289	6	vitro	vitro	FW
cord-006860-a3b8hyyr	3289	7	data	datum	NNS
cord-006860-a3b8hyyr	3289	8	was	be	VBD
cord-006860-a3b8hyyr	3289	9	confirmed	confirm	VBN
cord-006860-a3b8hyyr	3289	10	in	in	IN
cord-006860-a3b8hyyr	3289	11	vivo	vivo	NN
cord-006860-a3b8hyyr	3289	12	in	in	IN
cord-006860-a3b8hyyr	3289	13	mice	mouse	NNS
cord-006860-a3b8hyyr	3289	14	bearing	bear	VBG
cord-006860-a3b8hyyr	3289	15	Meth	Meth	NNP
cord-006860-a3b8hyyr	3289	16	-	-	HYPH
cord-006860-a3b8hyyr	3289	17	A	a	NN
cord-006860-a3b8hyyr	3289	18	-	-	HYPH
cord-006860-a3b8hyyr	3289	19	sarcoma	sarcoma	NN
cord-006860-a3b8hyyr	3289	20	.	.	.
cord-006860-a3b8hyyr	3290	1	When	when	WRB
cord-006860-a3b8hyyr	3290	2	mice	mouse	NNS
cord-006860-a3b8hyyr	3290	3	received	receive	VBD
cord-006860-a3b8hyyr	3290	4	curcumin	curcumin	NN
cord-006860-a3b8hyyr	3290	5	before	before	IN
cord-006860-a3b8hyyr	3290	6	TNFa	TNFa	NNS
cord-006860-a3b8hyyr	3290	7	was	be	VBD
cord-006860-a3b8hyyr	3290	8	injected	inject	VBN
cord-006860-a3b8hyyr	3290	9	,	,	,
cord-006860-a3b8hyyr	3290	10	tumors	tumor	NNS
cord-006860-a3b8hyyr	3290	11	showed	show	VBD
cord-006860-a3b8hyyr	3290	12	reduced	reduce	VBN
cord-006860-a3b8hyyr	3290	13	AP-1	AP-1	NNP
cord-006860-a3b8hyyr	3290	14	activation	activation	NN
cord-006860-a3b8hyyr	3290	15	.	.	.
cord-006860-a3b8hyyr	3291	1	Simultanously	Simultanously	NNP
cord-006860-a3b8hyyr	3291	2	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3291	3	/	/	SYM
cord-006860-a3b8hyyr	3291	4	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3291	5	deposition	deposition	NN
cord-006860-a3b8hyyr	3291	6	decreased	decrease	VBD
cord-006860-a3b8hyyr	3291	7	,	,	,
cord-006860-a3b8hyyr	3291	8	most	most	RBS
cord-006860-a3b8hyyr	3291	9	probably	probably	RB
cord-006860-a3b8hyyr	3291	10	due	due	JJ
cord-006860-a3b8hyyr	3291	11	to	to	IN
cord-006860-a3b8hyyr	3291	12	reduced	reduce	VBN
cord-006860-a3b8hyyr	3291	13	Tissue	tissue	NN
cord-006860-a3b8hyyr	3291	14	Factor	Factor	NNP
cord-006860-a3b8hyyr	3291	15	expression	expression	NN
cord-006860-a3b8hyyr	3291	16	.	.	.
cord-006860-a3b8hyyr	3292	1	Thus	thus	RB
cord-006860-a3b8hyyr	3292	2	,	,	,
cord-006860-a3b8hyyr	3292	3	curcumin	curcumin	NN
cord-006860-a3b8hyyr	3292	4	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	3292	5	AP	AP	NNP
cord-006860-a3b8hyyr	3292	6	-	-	HYPH
cord-006860-a3b8hyyr	3292	7	t	t	NNP
cord-006860-a3b8hyyr	3292	8	activation	activation	NN
cord-006860-a3b8hyyr	3292	9	and	and	CC
cord-006860-a3b8hyyr	3292	10	expression	expression	NN
cord-006860-a3b8hyyr	3292	11	of	of	IN
cord-006860-a3b8hyyr	3292	12	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	3292	13	genes	gene	NNS
cord-006860-a3b8hyyr	3292	14	controlled	control	VBN
cord-006860-a3b8hyyr	3292	15	by	by	IN
cord-006860-a3b8hyyr	3292	16	AP	AP	NNP
cord-006860-a3b8hyyr	3292	17	-	-	HYPH
cord-006860-a3b8hyyr	3292	18	t	t	NNP
cord-006860-a3b8hyyr	3292	19	in	in	IN
cord-006860-a3b8hyyr	3292	20	vitro	vitro	FW
cord-006860-a3b8hyyr	3292	21	and	and	CC
cord-006860-a3b8hyyr	3292	22	in	in	IN
cord-006860-a3b8hyyr	3292	23	vivo	vivo	NNP
cord-006860-a3b8hyyr	3292	24	.	.	.
cord-006860-a3b8hyyr	3293	1	(	(	-LRB-
cord-006860-a3b8hyyr	3293	2	Jung	Jung	NNP
cord-006860-a3b8hyyr	3293	3	,	,	,
cord-006860-a3b8hyyr	3293	4	1991	1991	CD
cord-006860-a3b8hyyr	3293	5	)	)	-RRB-
cord-006860-a3b8hyyr	3293	6	.	.	.
cord-006860-a3b8hyyr	3294	1	Additionally	additionally	RB
cord-006860-a3b8hyyr	3294	2	,	,	,
cord-006860-a3b8hyyr	3294	3	haemorhenlogical	haemorhenlogical	JJ
cord-006860-a3b8hyyr	3294	4	parameters	parameter	NNS
cord-006860-a3b8hyyr	3294	5	(	(	-LRB-
cord-006860-a3b8hyyr	3294	6	plasma	plasma	NN
cord-006860-a3b8hyyr	3294	7	viscosity	viscosity	NN
cord-006860-a3b8hyyr	3294	8	,	,	,
cord-006860-a3b8hyyr	3294	9	erythrocyte	erythrocyte	NN
cord-006860-a3b8hyyr	3294	10	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3294	11	)	)	-RRB-
cord-006860-a3b8hyyr	3294	12	were	be	VBD
cord-006860-a3b8hyyr	3294	13	measured	measure	VBN
cord-006860-a3b8hyyr	3294	14	.	.	.
cord-006860-a3b8hyyr	3295	1	In	in	IN
cord-006860-a3b8hyyr	3295	2	all	all	DT
cord-006860-a3b8hyyr	3295	3	patients	patient	NNS
cord-006860-a3b8hyyr	3295	4	aPTT	aptt	JJ
cord-006860-a3b8hyyr	3295	5	,	,	,
cord-006860-a3b8hyyr	3295	6	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3295	7	time	time	NN
cord-006860-a3b8hyyr	3295	8	,	,	,
cord-006860-a3b8hyyr	3295	9	platelet	platelet	NN
cord-006860-a3b8hyyr	3295	10	adhesiveness	adhesiveness	NN
cord-006860-a3b8hyyr	3295	11	,	,	,
cord-006860-a3b8hyyr	3295	12	von	von	NNP
cord-006860-a3b8hyyr	3295	13	WiUebrand	WiUebrand	NNP
cord-006860-a3b8hyyr	3295	14	f	f	NNP
cord-006860-a3b8hyyr	3295	15	~	~	CD
cord-006860-a3b8hyyr	3295	16	ctor	ctor	NN
cord-006860-a3b8hyyr	3295	17	and	and	CC
cord-006860-a3b8hyyr	3295	18	factor	factor	NN
cord-006860-a3b8hyyr	3295	19	VIII	VIII	NNP
cord-006860-a3b8hyyr	3295	20	concentration	concentration	NN
cord-006860-a3b8hyyr	3295	21	and	and	CC
cord-006860-a3b8hyyr	3295	22	activity	activity	NN
cord-006860-a3b8hyyr	3295	23	were	be	VBD
cord-006860-a3b8hyyr	3295	24	determined	determine	VBN
cord-006860-a3b8hyyr	3295	25	.	.	.
cord-006860-a3b8hyyr	3296	1	The	the	DT
cord-006860-a3b8hyyr	3296	2	patients	patient	NNS
cord-006860-a3b8hyyr	3296	3	with	with	IN
cord-006860-a3b8hyyr	3296	4	von	von	NNP
cord-006860-a3b8hyyr	3296	5	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	3296	6	disease	disease	NN
cord-006860-a3b8hyyr	3296	7	showed	show	VBD
cord-006860-a3b8hyyr	3296	8	characteristic	characteristic	JJ
cord-006860-a3b8hyyr	3296	9	morphological	morphological	JJ
cord-006860-a3b8hyyr	3296	10	changes	change	NNS
cord-006860-a3b8hyyr	3296	11	of	of	IN
cord-006860-a3b8hyyr	3296	12	capillary	capillary	JJ
cord-006860-a3b8hyyr	3296	13	geometry	geometry	NN
cord-006860-a3b8hyyr	3296	14	.	.	.
cord-006860-a3b8hyyr	3297	1	Tortuosity	Tortuosity	NNP
cord-006860-a3b8hyyr	3297	2	of	of	IN
cord-006860-a3b8hyyr	3297	3	nailfold	nailfold	JJ
cord-006860-a3b8hyyr	3297	4	capillaries	capillary	NNS
cord-006860-a3b8hyyr	3297	5	was	be	VBD
cord-006860-a3b8hyyr	3297	6	markedly	markedly	RB
cord-006860-a3b8hyyr	3297	7	increased	increase	VBN
cord-006860-a3b8hyyr	3297	8	as	as	RB
cord-006860-a3b8hyyr	3297	9	well	well	RB
cord-006860-a3b8hyyr	3297	10	as	as	IN
cord-006860-a3b8hyyr	3297	11	the	the	DT
cord-006860-a3b8hyyr	3297	12	diameter	diameter	NN
cord-006860-a3b8hyyr	3297	13	of	of	IN
cord-006860-a3b8hyyr	3297	14	capillariez	capillariez	NNP
cord-006860-a3b8hyyr	3297	15	on	on	IN
cord-006860-a3b8hyyr	3297	16	the	the	DT
cord-006860-a3b8hyyr	3297	17	arterial	arterial	JJ
cord-006860-a3b8hyyr	3297	18	and	and	CC
cord-006860-a3b8hyyr	3297	19	venous	venous	JJ
cord-006860-a3b8hyyr	3297	20	side	side	NN
cord-006860-a3b8hyyr	3297	21	.	.	.
cord-006860-a3b8hyyr	3298	1	Plasma	plasma	NN
cord-006860-a3b8hyyr	3298	2	viscosity	viscosity	NN
cord-006860-a3b8hyyr	3298	3	was	be	VBD
cord-006860-a3b8hyyr	3298	4	significantly	significantly	RB
cord-006860-a3b8hyyr	3298	5	low	low	JJ
cord-006860-a3b8hyyr	3298	6	.	.	.
cord-006860-a3b8hyyr	3299	1	Multiple	multiple	JJ
cord-006860-a3b8hyyr	3299	2	parameter	parameter	NN
cord-006860-a3b8hyyr	3299	3	analysis	analysis	NN
cord-006860-a3b8hyyr	3299	4	concerning	concern	VBG
cord-006860-a3b8hyyr	3299	5	to	to	IN
cord-006860-a3b8hyyr	3299	6	Galen	Galen	NNP
cord-006860-a3b8hyyr	3299	7	and	and	CC
cord-006860-a3b8hyyr	3299	8	Gambino	Gambino	NNP
cord-006860-a3b8hyyr	3299	9	(	(	-LRB-
cord-006860-a3b8hyyr	3299	10	1983	1983	CD
cord-006860-a3b8hyyr	3299	11	)	)	-RRB-
cord-006860-a3b8hyyr	3299	12	and	and	CC
cord-006860-a3b8hyyr	3299	13	using	use	VBG
cord-006860-a3b8hyyr	3299	14	the	the	DT
cord-006860-a3b8hyyr	3299	15	parameters	parameter	NNS
cord-006860-a3b8hyyr	3299	16	,	,	,
cord-006860-a3b8hyyr	3299	17	,	,	,
cord-006860-a3b8hyyr	3299	18	plasma	plasma	NN
cord-006860-a3b8hyyr	3299	19	viscosity	viscosity	NN
cord-006860-a3b8hyyr	3299	20	below	below	IN
cord-006860-a3b8hyyr	3299	21	1.25	1.25	CD
cord-006860-a3b8hyyr	3299	22	mPas	mPas	NNP
cord-006860-a3b8hyyr	3299	23	"	"	''
cord-006860-a3b8hyyr	3299	24	,	,	,
cord-006860-a3b8hyyr	3299	25	,	,	,
cord-006860-a3b8hyyr	3299	26	,	,	,
cord-006860-a3b8hyyr	3299	27	torquation	torquation	NN
cord-006860-a3b8hyyr	3299	28	index	index	NN
cord-006860-a3b8hyyr	3299	29	higher	high	JJR
cord-006860-a3b8hyyr	3299	30	than	than	IN
cord-006860-a3b8hyyr	3299	31	5	5	CD
cord-006860-a3b8hyyr	3299	32	"	"	''
cord-006860-a3b8hyyr	3299	33	,	,	,
cord-006860-a3b8hyyr	3299	34	,	,	,
cord-006860-a3b8hyyr	3300	1	,	,	,
cord-006860-a3b8hyyr	3300	2	erythrocyte	erythrocyte	NN
cord-006860-a3b8hyyr	3300	3	column	column	NN
cord-006860-a3b8hyyr	3300	4	diameter	diameter	NN
cord-006860-a3b8hyyr	3300	5	bigger	big	JJR
cord-006860-a3b8hyyr	3300	6	than	than	IN
cord-006860-a3b8hyyr	3300	7	16,9	16,9	CD
cord-006860-a3b8hyyr	3300	8	gin	gin	NN
cord-006860-a3b8hyyr	3300	9	"	"	''
cord-006860-a3b8hyyr	3300	10	showed	show	VBD
cord-006860-a3b8hyyr	3300	11	a	a	DT
cord-006860-a3b8hyyr	3300	12	positive	positive	JJ
cord-006860-a3b8hyyr	3300	13	predictive	predictive	JJ
cord-006860-a3b8hyyr	3300	14	value	value	NN
cord-006860-a3b8hyyr	3300	15	of	of	IN
cord-006860-a3b8hyyr	3300	16	100	100	CD
cord-006860-a3b8hyyr	3300	17	%	%	NN
cord-006860-a3b8hyyr	3300	18	.	.	.
cord-006860-a3b8hyyr	3301	1	Capillary	capillary	JJ
cord-006860-a3b8hyyr	3301	2	diameter	diameter	NN
cord-006860-a3b8hyyr	3301	3	and	and	CC
cord-006860-a3b8hyyr	3301	4	capillary	capillary	JJ
cord-006860-a3b8hyyr	3301	5	tortuosity	tortuosity	NN
cord-006860-a3b8hyyr	3301	6	have	have	VBP
cord-006860-a3b8hyyr	3301	7	a	a	DT
cord-006860-a3b8hyyr	3301	8	positive	positive	JJ
cord-006860-a3b8hyyr	3301	9	predictive	predictive	JJ
cord-006860-a3b8hyyr	3301	10	value	value	NN
cord-006860-a3b8hyyr	3301	11	of	of	IN
cord-006860-a3b8hyyr	3301	12	91,2	91,2	CD
cord-006860-a3b8hyyr	3301	13	%	%	NN
cord-006860-a3b8hyyr	3301	14	.	.	.
cord-006860-a3b8hyyr	3302	1	Additionally	additionally	RB
cord-006860-a3b8hyyr	3302	2	,	,	,
cord-006860-a3b8hyyr	3302	3	a	a	DT
cord-006860-a3b8hyyr	3302	4	reduction	reduction	NN
cord-006860-a3b8hyyr	3302	5	of	of	IN
cord-006860-a3b8hyyr	3302	6	the	the	DT
cord-006860-a3b8hyyr	3302	7	vasomotorie	vasomotorie	NN
cord-006860-a3b8hyyr	3302	8	reserve	reserve	NN
cord-006860-a3b8hyyr	3302	9	and/or	and/or	CC
cord-006860-a3b8hyyr	3302	10	a	a	DT
cord-006860-a3b8hyyr	3302	11	decreased	decrease	VBN
cord-006860-a3b8hyyr	3302	12	erythrocyte	erythrocyte	NN
cord-006860-a3b8hyyr	3302	13	velocity	velocity	NN
cord-006860-a3b8hyyr	3302	14	in	in	IN
cord-006860-a3b8hyyr	3302	15	the	the	DT
cord-006860-a3b8hyyr	3302	16	capillaries	capillary	NNS
cord-006860-a3b8hyyr	3302	17	below	below	IN
cord-006860-a3b8hyyr	3302	18	the	the	DT
cord-006860-a3b8hyyr	3302	19	reference	reference	NN
cord-006860-a3b8hyyr	3302	20	range	range	NN
cord-006860-a3b8hyyr	3302	21	was	be	VBD
cord-006860-a3b8hyyr	3302	22	found	find	VBN
cord-006860-a3b8hyyr	3302	23	in	in	IN
cord-006860-a3b8hyyr	3302	24	most	most	JJS
cord-006860-a3b8hyyr	3302	25	of	of	IN
cord-006860-a3b8hyyr	3302	26	the	the	DT
cord-006860-a3b8hyyr	3302	27	yon	yon	NNP
cord-006860-a3b8hyyr	3302	28	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	3302	29	patients	patient	NNS
cord-006860-a3b8hyyr	3302	30	.	.	.
cord-006860-a3b8hyyr	3303	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	3303	2	was	be	VBD
cord-006860-a3b8hyyr	3303	3	quite	quite	RB
cord-006860-a3b8hyyr	3303	4	remarkable	remarkable	JJ
cord-006860-a3b8hyyr	3303	5	,	,	,
cord-006860-a3b8hyyr	3303	6	that	that	IN
cord-006860-a3b8hyyr	3303	7	16	16	CD
cord-006860-a3b8hyyr	3303	8	of	of	IN
cord-006860-a3b8hyyr	3303	9	40	40	CD
cord-006860-a3b8hyyr	3303	10	of	of	IN
cord-006860-a3b8hyyr	3303	11	the	the	DT
cord-006860-a3b8hyyr	3303	12	yon	yon	NNP
cord-006860-a3b8hyyr	3303	13	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	3303	14	patients	patient	NNS
cord-006860-a3b8hyyr	3303	15	showed	show	VBD
cord-006860-a3b8hyyr	3303	16	significant	significant	JJ
cord-006860-a3b8hyyr	3303	17	capillary	capillary	JJ
cord-006860-a3b8hyyr	3303	18	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	3303	19	.	.	.
cord-006860-a3b8hyyr	3304	1	These	these	DT
cord-006860-a3b8hyyr	3304	2	findings	finding	NNS
cord-006860-a3b8hyyr	3304	3	confirm	confirm	VBP
cord-006860-a3b8hyyr	3304	4	some	some	DT
cord-006860-a3b8hyyr	3304	5	former	former	JJ
cord-006860-a3b8hyyr	3304	6	observations	observation	NNS
cord-006860-a3b8hyyr	3304	7	(	(	-LRB-
cord-006860-a3b8hyyr	3304	8	e.g.	e.g.	RB
cord-006860-a3b8hyyr	3304	9	O'Brian	O'Brian	NNP
cord-006860-a3b8hyyr	3304	10	1950	1950	CD
cord-006860-a3b8hyyr	3304	11	)	)	-RRB-
cord-006860-a3b8hyyr	3304	12	and	and	CC
cord-006860-a3b8hyyr	3304	13	preliminary	preliminary	JJ
cord-006860-a3b8hyyr	3304	14	reports	report	NNS
cord-006860-a3b8hyyr	3304	15	of	of	IN
cord-006860-a3b8hyyr	3304	16	our	-PRON-	PRP$
cord-006860-a3b8hyyr	3304	17	group	group	NN
cord-006860-a3b8hyyr	3304	18	(	(	-LRB-
cord-006860-a3b8hyyr	3304	19	Koscielny	Koscielny	NNP
cord-006860-a3b8hyyr	3304	20	1994	1994	CD
cord-006860-a3b8hyyr	3304	21	)	)	-RRB-
cord-006860-a3b8hyyr	3304	22	.	.	.
cord-006860-a3b8hyyr	3305	1	Polymerase	polymerase	NN
cord-006860-a3b8hyyr	3305	2	chain	chain	NN
cord-006860-a3b8hyyr	3305	3	reaction	reaction	NN
cord-006860-a3b8hyyr	3305	4	(	(	-LRB-
cord-006860-a3b8hyyr	3306	1	PCR)-based	pcr)-based	JJ
cord-006860-a3b8hyyr	3306	2	quantitation	quantitation	NN
cord-006860-a3b8hyyr	3306	3	of	of	IN
cord-006860-a3b8hyyr	3306	4	mRNA	mRNA	NNP
cord-006860-a3b8hyyr	3306	5	transcripts	transcript	NNS
cord-006860-a3b8hyyr	3306	6	is	be	VBZ
cord-006860-a3b8hyyr	3306	7	an	an	DT
cord-006860-a3b8hyyr	3306	8	important	important	JJ
cord-006860-a3b8hyyr	3306	9	tool	tool	NN
cord-006860-a3b8hyyr	3306	10	in	in	IN
cord-006860-a3b8hyyr	3306	11	the	the	DT
cord-006860-a3b8hyyr	3306	12	investigation	investigation	NN
cord-006860-a3b8hyyr	3306	13	of	of	IN
cord-006860-a3b8hyyr	3306	14	the	the	DT
cord-006860-a3b8hyyr	3306	15	underlying	underlying	JJ
cord-006860-a3b8hyyr	3306	16	molecular	molecular	JJ
cord-006860-a3b8hyyr	3306	17	defects	defect	NNS
cord-006860-a3b8hyyr	3306	18	in	in	IN
cord-006860-a3b8hyyr	3306	19	inherited	inherit	VBN
cord-006860-a3b8hyyr	3306	20	platelet	platelet	NN
cord-006860-a3b8hyyr	3306	21	disorders	disorder	NNS
cord-006860-a3b8hyyr	3306	22	,	,	,
cord-006860-a3b8hyyr	3306	23	such	such	JJ
cord-006860-a3b8hyyr	3306	24	as	as	IN
cord-006860-a3b8hyyr	3306	25	the	the	DT
cord-006860-a3b8hyyr	3306	26	Bernard	Bernard	NNP
cord-006860-a3b8hyyr	3306	27	-	-	HYPH
cord-006860-a3b8hyyr	3306	28	Soulier	Soulier	NNP
cord-006860-a3b8hyyr	3306	29	syndrome	syndrome	NN
cord-006860-a3b8hyyr	3306	30	.	.	.
cord-006860-a3b8hyyr	3307	1	However	however	RB
cord-006860-a3b8hyyr	3307	2	,	,	,
cord-006860-a3b8hyyr	3307	3	for	for	IN
cord-006860-a3b8hyyr	3307	4	the	the	DT
cord-006860-a3b8hyyr	3307	5	exact	exact	JJ
cord-006860-a3b8hyyr	3307	6	quantitation	quantitation	NN
cord-006860-a3b8hyyr	3307	7	of	of	IN
cord-006860-a3b8hyyr	3307	8	mRNA	mRNA	NNP
cord-006860-a3b8hyyr	3307	9	a	a	DT
cord-006860-a3b8hyyr	3307	10	number	number	NN
cord-006860-a3b8hyyr	3307	11	of	of	IN
cord-006860-a3b8hyyr	3307	12	methological	methological	JJ
cord-006860-a3b8hyyr	3307	13	requirements	requirement	NNS
cord-006860-a3b8hyyr	3307	14	has	have	VBZ
cord-006860-a3b8hyyr	3307	15	to	to	TO
cord-006860-a3b8hyyr	3307	16	be	be	VB
cord-006860-a3b8hyyr	3307	17	met	meet	VBN
cord-006860-a3b8hyyr	3307	18	.	.	.
cord-006860-a3b8hyyr	3308	1	First	first	RB
cord-006860-a3b8hyyr	3308	2	,	,	,
cord-006860-a3b8hyyr	3308	3	a	a	DT
cord-006860-a3b8hyyr	3308	4	standard	standard	NN
cord-006860-a3b8hyyr	3308	5	(	(	-LRB-
cord-006860-a3b8hyyr	3308	6	s	s	NN
cord-006860-a3b8hyyr	3308	7	)	)	-RRB-
cord-006860-a3b8hyyr	3308	8	mRNA	mrna	NN
cord-006860-a3b8hyyr	3308	9	must	must	MD
cord-006860-a3b8hyyr	3308	10	be	be	VB
cord-006860-a3b8hyyr	3308	11	synthesized	synthesize	VBN
cord-006860-a3b8hyyr	3308	12	which	which	WDT
cord-006860-a3b8hyyr	3308	13	is	be	VBZ
cord-006860-a3b8hyyr	3308	14	able	able	JJ
cord-006860-a3b8hyyr	3308	15	to	to	TO
cord-006860-a3b8hyyr	3308	16	undergo	undergo	VB
cord-006860-a3b8hyyr	3308	17	the	the	DT
cord-006860-a3b8hyyr	3308	18	same	same	JJ
cord-006860-a3b8hyyr	3308	19	processing	processing	NN
cord-006860-a3b8hyyr	3308	20	as	as	IN
cord-006860-a3b8hyyr	3308	21	the	the	DT
cord-006860-a3b8hyyr	3308	22	target	target	NN
cord-006860-a3b8hyyr	3308	23	wild	wild	JJ
cord-006860-a3b8hyyr	3308	24	type	type	NN
cord-006860-a3b8hyyr	3308	25	(	(	-LRB-
cord-006860-a3b8hyyr	3308	26	wt	wt	NN
cord-006860-a3b8hyyr	3308	27	)	)	-RRB-
cord-006860-a3b8hyyr	3308	28	mRNA	mrna	NN
cord-006860-a3b8hyyr	3308	29	.	.	.
cord-006860-a3b8hyyr	3309	1	Secondly	secondly	RB
cord-006860-a3b8hyyr	3309	2	,	,	,
cord-006860-a3b8hyyr	3309	3	the	the	DT
cord-006860-a3b8hyyr	3309	4	quantitation	quantitation	NN
cord-006860-a3b8hyyr	3309	5	step	step	NN
cord-006860-a3b8hyyr	3309	6	following	follow	VBG
cord-006860-a3b8hyyr	3309	7	the	the	DT
cord-006860-a3b8hyyr	3309	8	PCR	PCR	NNP
cord-006860-a3b8hyyr	3309	9	must	must	MD
cord-006860-a3b8hyyr	3309	10	differentially	differentially	RB
cord-006860-a3b8hyyr	3309	11	recognize	recognize	VB
cord-006860-a3b8hyyr	3309	12	standard	standard	NN
cord-006860-a3b8hyyr	3309	13	and	and	CC
cord-006860-a3b8hyyr	3309	14	target	target	NN
cord-006860-a3b8hyyr	3309	15	DNA	DNA	NNP
cord-006860-a3b8hyyr	3309	16	,	,	,
cord-006860-a3b8hyyr	3309	17	and	and	CC
cord-006860-a3b8hyyr	3309	18	thirdly	thirdly	RB
cord-006860-a3b8hyyr	3309	19	,	,	,
cord-006860-a3b8hyyr	3309	20	the	the	DT
cord-006860-a3b8hyyr	3309	21	assay	assay	NN
cord-006860-a3b8hyyr	3309	22	must	must	MD
cord-006860-a3b8hyyr	3309	23	be	be	VB
cord-006860-a3b8hyyr	3309	24	precise	precise	JJ
cord-006860-a3b8hyyr	3309	25	with	with	IN
cord-006860-a3b8hyyr	3309	26	respect	respect	NN
cord-006860-a3b8hyyr	3309	27	to	to	IN
cord-006860-a3b8hyyr	3309	28	both	both	CC
cord-006860-a3b8hyyr	3309	29	inter	inter	JJ
cord-006860-a3b8hyyr	3309	30	-	-	:
cord-006860-a3b8hyyr	3309	31	and	and	CC
cord-006860-a3b8hyyr	3309	32	intraassay	intraassay	NNP
cord-006860-a3b8hyyr	3309	33	variability	variability	NN
cord-006860-a3b8hyyr	3309	34	.	.	.
cord-006860-a3b8hyyr	3310	1	In	in	IN
cord-006860-a3b8hyyr	3310	2	order	order	NN
cord-006860-a3b8hyyr	3310	3	to	to	TO
cord-006860-a3b8hyyr	3310	4	satisfy	satisfy	VB
cord-006860-a3b8hyyr	3310	5	these	these	DT
cord-006860-a3b8hyyr	3310	6	requirements	requirement	NNS
cord-006860-a3b8hyyr	3310	7	we	-PRON-	PRP
cord-006860-a3b8hyyr	3310	8	constructed	construct	VBD
cord-006860-a3b8hyyr	3310	9	a	a	DT
cord-006860-a3b8hyyr	3310	10	s	s	NNP
cord-006860-a3b8hyyr	3310	11	-	-	HYPH
cord-006860-a3b8hyyr	3310	12	GPIb	GPIb	NNP
cord-006860-a3b8hyyr	3310	13	mRNA	mrna	NN
cord-006860-a3b8hyyr	3310	14	which	which	WDT
cord-006860-a3b8hyyr	3310	15	is	be	VBZ
cord-006860-a3b8hyyr	3310	16	identical	identical	JJ
cord-006860-a3b8hyyr	3310	17	to	to	IN
cord-006860-a3b8hyyr	3310	18	the	the	DT
cord-006860-a3b8hyyr	3310	19	wt	wt	NN
cord-006860-a3b8hyyr	3310	20	-	-	HYPH
cord-006860-a3b8hyyr	3310	21	GPIb	GPIb	NNP
cord-006860-a3b8hyyr	3311	1	mRNA	mrna	NN
cord-006860-a3b8hyyr	3311	2	except	except	IN
cord-006860-a3b8hyyr	3311	3	a	a	DT
cord-006860-a3b8hyyr	3311	4	13	13	CD
cord-006860-a3b8hyyr	3311	5	bp	bp	NNP
cord-006860-a3b8hyyr	3311	6	long	long	JJ
cord-006860-a3b8hyyr	3311	7	primer	primer	NN
cord-006860-a3b8hyyr	3311	8	recognition	recognition	NN
cord-006860-a3b8hyyr	3311	9	site	site	NN
cord-006860-a3b8hyyr	3311	10	at	at	IN
cord-006860-a3b8hyyr	3311	11	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3311	12	5	5	CD
cord-006860-a3b8hyyr	3311	13	"	"	``
cord-006860-a3b8hyyr	3311	14	end	end	NN
cord-006860-a3b8hyyr	3311	15	allowing	allow	VBG
cord-006860-a3b8hyyr	3311	16	differentiation	differentiation	NN
cord-006860-a3b8hyyr	3311	17	between	between	IN
cord-006860-a3b8hyyr	3311	18	the	the	DT
cord-006860-a3b8hyyr	3311	19	PCR	PCR	NNP
cord-006860-a3b8hyyr	3311	20	amplified	amplify	VBN
cord-006860-a3b8hyyr	3311	21	wt	wt	NN
cord-006860-a3b8hyyr	3311	22	-	-	HYPH
cord-006860-a3b8hyyr	3311	23	or	or	CC
cord-006860-a3b8hyyr	3311	24	s	s	NNPS
cord-006860-a3b8hyyr	3311	25	-	-	HYPH
cord-006860-a3b8hyyr	3311	26	GPIb	GPIb	NNP
cord-006860-a3b8hyyr	3311	27	cDNA	cdna	NN
cord-006860-a3b8hyyr	3311	28	through	through	IN
cord-006860-a3b8hyyr	3311	29	incorporation	incorporation	NN
cord-006860-a3b8hyyr	3311	30	of	of	IN
cord-006860-a3b8hyyr	3311	31	a	a	DT
cord-006860-a3b8hyyr	3311	32	fluorescein	fluorescein	NN
cord-006860-a3b8hyyr	3311	33	or	or	CC
cord-006860-a3b8hyyr	3311	34	biotin	biotin	NN
cord-006860-a3b8hyyr	3311	35	labelled	label	VBD
cord-006860-a3b8hyyr	3311	36	5	5	CD
cord-006860-a3b8hyyr	3311	37	"	"	''
cord-006860-a3b8hyyr	3311	38	primer	primer	NN
cord-006860-a3b8hyyr	3311	39	.	.	.
cord-006860-a3b8hyyr	3312	1	Both	both	DT
cord-006860-a3b8hyyr	3312	2	standard	standard	NN
cord-006860-a3b8hyyr	3312	3	and	and	CC
cord-006860-a3b8hyyr	3312	4	w	w	NN
cord-006860-a3b8hyyr	3313	1	[	[	-LRB-
cord-006860-a3b8hyyr	3313	2	GPIb	GPIb	NNP
cord-006860-a3b8hyyr	3313	3	mRNA	mRNA	NNP
cord-006860-a3b8hyyr	3313	4	showed	show	VBD
cord-006860-a3b8hyyr	3313	5	identical	identical	JJ
cord-006860-a3b8hyyr	3313	6	amplification	amplification	NN
cord-006860-a3b8hyyr	3313	7	kinetics	kinetic	NNS
cord-006860-a3b8hyyr	3313	8	in	in	IN
cord-006860-a3b8hyyr	3313	9	the	the	DT
cord-006860-a3b8hyyr	3313	10	PCR	PCR	NNP
cord-006860-a3b8hyyr	3313	11	reaction	reaction	NN
cord-006860-a3b8hyyr	3313	12	.	.	.
cord-006860-a3b8hyyr	3314	1	The	the	DT
cord-006860-a3b8hyyr	3314	2	amplified	amplify	VBN
cord-006860-a3b8hyyr	3314	3	DNA	dna	NN
cord-006860-a3b8hyyr	3314	4	was	be	VBD
cord-006860-a3b8hyyr	3314	5	quantified	quantify	VBN
cord-006860-a3b8hyyr	3314	6	using	use	VBG
cord-006860-a3b8hyyr	3314	7	an	an	DT
cord-006860-a3b8hyyr	3314	8	DNA	dna	NN
cord-006860-a3b8hyyr	3314	9	binding	binding	NN
cord-006860-a3b8hyyr	3314	10	assay	assay	NN
cord-006860-a3b8hyyr	3314	11	.	.	.
cord-006860-a3b8hyyr	3315	1	In	in	IN
cord-006860-a3b8hyyr	3315	2	this	this	DT
cord-006860-a3b8hyyr	3315	3	assay	assay	NN
cord-006860-a3b8hyyr	3315	4	binding	bind	VBG
cord-006860-a3b8hyyr	3315	5	of	of	IN
cord-006860-a3b8hyyr	3315	6	amplified	amplify	VBN
cord-006860-a3b8hyyr	3315	7	DNA	dna	NN
cord-006860-a3b8hyyr	3315	8	to	to	IN
cord-006860-a3b8hyyr	3315	9	GCN4	GCN4	NNP
cord-006860-a3b8hyyr	3315	10	fusionprotein	fusionprotein	NN
cord-006860-a3b8hyyr	3315	11	-	-	HYPH
cord-006860-a3b8hyyr	3315	12	coated	coated	JJ
cord-006860-a3b8hyyr	3315	13	microtiterplates	microtiterplate	NNS
cord-006860-a3b8hyyr	3315	14	is	be	VBZ
cord-006860-a3b8hyyr	3315	15	measured	measure	VBN
cord-006860-a3b8hyyr	3315	16	.	.	.
cord-006860-a3b8hyyr	3316	1	Since	since	IN
cord-006860-a3b8hyyr	3316	2	the	the	DT
cord-006860-a3b8hyyr	3316	3	GCN4	GCN4	NNP
cord-006860-a3b8hyyr	3316	4	binding	binding	NN
cord-006860-a3b8hyyr	3316	5	motif	motif	NN
cord-006860-a3b8hyyr	3316	6	is	be	VBZ
cord-006860-a3b8hyyr	3316	7	incorporated	incorporate	VBN
cord-006860-a3b8hyyr	3316	8	into	into	IN
cord-006860-a3b8hyyr	3316	9	the	the	DT
cord-006860-a3b8hyyr	3316	10	wt	wt	NN
cord-006860-a3b8hyyr	3316	11	-	-	HYPH
cord-006860-a3b8hyyr	3316	12	and	and	CC
cord-006860-a3b8hyyr	3316	13	s	s	NNPS
cord-006860-a3b8hyyr	3316	14	-	-	HYPH
cord-006860-a3b8hyyr	3316	15	GPIb	GPIb	NNP
cord-006860-a3b8hyyr	3316	16	cDNA	cdna	NN
cord-006860-a3b8hyyr	3316	17	through	through	IN
cord-006860-a3b8hyyr	3316	18	an	an	DT
cord-006860-a3b8hyyr	3316	19	identical	identical	JJ
cord-006860-a3b8hyyr	3316	20	3	3	CD
cord-006860-a3b8hyyr	3316	21	"	"	``
cord-006860-a3b8hyyr	3316	22	primer	primer	NN
cord-006860-a3b8hyyr	3316	23	,	,	,
cord-006860-a3b8hyyr	3316	24	competition	competition	NN
cord-006860-a3b8hyyr	3316	25	between	between	IN
cord-006860-a3b8hyyr	3316	26	s	s	NN
cord-006860-a3b8hyyr	3316	27	-	-	:
cord-006860-a3b8hyyr	3316	28	and	and	CC
cord-006860-a3b8hyyr	3316	29	wt	wt	NN
cord-006860-a3b8hyyr	3316	30	-	-	HYPH
cord-006860-a3b8hyyr	3316	31	cDNA	cdna	NN
cord-006860-a3b8hyyr	3316	32	during	during	IN
cord-006860-a3b8hyyr	3316	33	amplification	amplification	NN
cord-006860-a3b8hyyr	3316	34	has	have	VBZ
cord-006860-a3b8hyyr	3316	35	been	be	VBN
cord-006860-a3b8hyyr	3316	36	analyzed	analyze	VBN
cord-006860-a3b8hyyr	3316	37	.	.	.
cord-006860-a3b8hyyr	3317	1	At	at	IN
cord-006860-a3b8hyyr	3317	2	a	a	DT
cord-006860-a3b8hyyr	3317	3	given	give	VBN
cord-006860-a3b8hyyr	3317	4	concentration	concentration	NN
cord-006860-a3b8hyyr	3317	5	of	of	IN
cord-006860-a3b8hyyr	3317	6	250	250	CD
cord-006860-a3b8hyyr	3317	7	nM	nm	CD
cord-006860-a3b8hyyr	3317	8	of	of	IN
cord-006860-a3b8hyyr	3317	9	GCN4	GCN4	NNP
cord-006860-a3b8hyyr	3317	10	.	.	.
cord-006860-a3b8hyyr	3318	1	primer	primer	VB
cord-006860-a3b8hyyr	3318	2	no	no	DT
cord-006860-a3b8hyyr	3318	3	competition	competition	NN
cord-006860-a3b8hyyr	3318	4	between	between	IN
cord-006860-a3b8hyyr	3318	5	the	the	DT
cord-006860-a3b8hyyr	3318	6	sDNA	sdna	NN
cord-006860-a3b8hyyr	3318	7	and	and	CC
cord-006860-a3b8hyyr	3318	8	wt	wt	NN
cord-006860-a3b8hyyr	3318	9	-	-	HYPH
cord-006860-a3b8hyyr	3318	10	DNA	dna	NN
cord-006860-a3b8hyyr	3318	11	for	for	IN
cord-006860-a3b8hyyr	3318	12	the	the	DT
cord-006860-a3b8hyyr	3318	13	primer	primer	NN
cord-006860-a3b8hyyr	3318	14	was	be	VBD
cord-006860-a3b8hyyr	3318	15	observed	observe	VBN
cord-006860-a3b8hyyr	3318	16	during	during	IN
cord-006860-a3b8hyyr	3318	17	25	25	CD
cord-006860-a3b8hyyr	3318	18	PCR	PCR	NNP
cord-006860-a3b8hyyr	3318	19	cycles	cycle	NNS
cord-006860-a3b8hyyr	3318	20	.	.	.
cord-006860-a3b8hyyr	3319	1	The	the	DT
cord-006860-a3b8hyyr	3319	2	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	3319	3	limit	limit	NN
cord-006860-a3b8hyyr	3319	4	of	of	IN
cord-006860-a3b8hyyr	3319	5	the	the	DT
cord-006860-a3b8hyyr	3319	6	assay	assay	NN
cord-006860-a3b8hyyr	3319	7	performed	perform	VBN
cord-006860-a3b8hyyr	3319	8	in	in	IN
cord-006860-a3b8hyyr	3319	9	this	this	DT
cord-006860-a3b8hyyr	3319	10	way	way	NN
cord-006860-a3b8hyyr	3319	11	was	be	VBD
cord-006860-a3b8hyyr	3319	12	250	250	CD
cord-006860-a3b8hyyr	3319	13	amol	amol	NNP
cord-006860-a3b8hyyr	3319	14	wt	wt	NNP
cord-006860-a3b8hyyr	3319	15	-	-	HYPH
cord-006860-a3b8hyyr	3319	16	GPIb~	GPIb~	NNP
cord-006860-a3b8hyyr	3319	17	,	,	,
cord-006860-a3b8hyyr	3319	18	DNA	DNA	NNP
cord-006860-a3b8hyyr	3319	19	,	,	,
cord-006860-a3b8hyyr	3319	20	and	and	CC
cord-006860-a3b8hyyr	3319	21	intraassay	intraassay	NNP
cord-006860-a3b8hyyr	3319	22	variability	variability	NN
cord-006860-a3b8hyyr	3319	23	reached	reach	VBN
cord-006860-a3b8hyyr	3319	24	from	from	IN
cord-006860-a3b8hyyr	3319	25	1.66	1.66	CD
cord-006860-a3b8hyyr	3319	26	%	%	NN
cord-006860-a3b8hyyr	3319	27	to	to	TO
cord-006860-a3b8hyyr	3319	28	6.72	6.72	CD
cord-006860-a3b8hyyr	3319	29	%	%	NN
cord-006860-a3b8hyyr	3319	30	calculated	calculate	VBN
cord-006860-a3b8hyyr	3319	31	for	for	IN
cord-006860-a3b8hyyr	3319	32	100	100	CD
cord-006860-a3b8hyyr	3319	33	fmol	fmol	NNS
cord-006860-a3b8hyyr	3319	34	and	and	CC
cord-006860-a3b8hyyr	3319	35	5	5	CD
cord-006860-a3b8hyyr	3319	36	fmol	fmol	JJ
cord-006860-a3b8hyyr	3319	37	DNA	DNA	NNP
cord-006860-a3b8hyyr	3319	38	,	,	,
cord-006860-a3b8hyyr	3319	39	respectively	respectively	RB
cord-006860-a3b8hyyr	3319	40	.	.	.
cord-006860-a3b8hyyr	3320	1	To	to	TO
cord-006860-a3b8hyyr	3320	2	sum	sum	VB
cord-006860-a3b8hyyr	3320	3	up	up	RP
cord-006860-a3b8hyyr	3320	4	,	,	,
cord-006860-a3b8hyyr	3320	5	combination	combination	NN
cord-006860-a3b8hyyr	3320	6	of	of	IN
cord-006860-a3b8hyyr	3320	7	RT	RT	NNP
cord-006860-a3b8hyyr	3320	8	-	-	HYPH
cord-006860-a3b8hyyr	3320	9	PCR	PCR	NNP
cord-006860-a3b8hyyr	3320	10	with	with	IN
cord-006860-a3b8hyyr	3320	11	the	the	DT
cord-006860-a3b8hyyr	3320	12	amplified	amplify	VBN
cord-006860-a3b8hyyr	3320	13	DNA	dna	NN
cord-006860-a3b8hyyr	3320	14	binding	binding	NN
cord-006860-a3b8hyyr	3320	15	assay	assay	NN
cord-006860-a3b8hyyr	3320	16	and	and	CC
cord-006860-a3b8hyyr	3320	17	usage	usage	NN
cord-006860-a3b8hyyr	3320	18	of	of	IN
cord-006860-a3b8hyyr	3320	19	an	an	DT
cord-006860-a3b8hyyr	3320	20	internal	internal	JJ
cord-006860-a3b8hyyr	3320	21	standard	standard	NN
cord-006860-a3b8hyyr	3320	22	mRNA	mRNA	NNP
cord-006860-a3b8hyyr	3320	23	allows	allow	VBZ
cord-006860-a3b8hyyr	3320	24	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	3320	25	and	and	CC
cord-006860-a3b8hyyr	3320	26	accurate	accurate	JJ
cord-006860-a3b8hyyr	3320	27	quantitation	quantitation	NN
cord-006860-a3b8hyyr	3320	28	of	of	IN
cord-006860-a3b8hyyr	3320	29	GPIba	GPIba	NNP
cord-006860-a3b8hyyr	3320	30	mRNA	mRNA	NNP
cord-006860-a3b8hyyr	3320	31	in	in	IN
cord-006860-a3b8hyyr	3320	32	human	human	JJ
cord-006860-a3b8hyyr	3320	33	platelets	platelet	NNS
cord-006860-a3b8hyyr	3320	34	.	.	.
cord-006860-a3b8hyyr	3321	1	Since	since	IN
cord-006860-a3b8hyyr	3321	2	uPA	upa	NN
cord-006860-a3b8hyyr	3321	3	and	and	CC
cord-006860-a3b8hyyr	3321	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3321	5	are	be	VBP
cord-006860-a3b8hyyr	3321	6	main	main	JJ
cord-006860-a3b8hyyr	3321	7	conrtibutors	conrtibutor	NNS
cord-006860-a3b8hyyr	3321	8	to	to	IN
cord-006860-a3b8hyyr	3321	9	the	the	DT
cord-006860-a3b8hyyr	3321	10	process	process	NN
cord-006860-a3b8hyyr	3321	11	of	of	IN
cord-006860-a3b8hyyr	3321	12	proliferation	proliferation	NN
cord-006860-a3b8hyyr	3321	13	and	and	CC
cord-006860-a3b8hyyr	3321	14	migration	migration	NN
cord-006860-a3b8hyyr	3321	15	of	of	IN
cord-006860-a3b8hyyr	3321	16	vascular	vascular	JJ
cord-006860-a3b8hyyr	3321	17	smooth	smooth	JJ
cord-006860-a3b8hyyr	3321	18	muscle	muscle	NN
cord-006860-a3b8hyyr	3321	19	cells	cell	NNS
cord-006860-a3b8hyyr	3321	20	(	(	-LRB-
cord-006860-a3b8hyyr	3321	21	VSMC	VSMC	NNP
cord-006860-a3b8hyyr	3321	22	)	)	-RRB-
cord-006860-a3b8hyyr	3321	23	,	,	,
cord-006860-a3b8hyyr	3321	24	which	which	WDT
cord-006860-a3b8hyyr	3321	25	is	be	VBZ
cord-006860-a3b8hyyr	3321	26	part	part	NN
cord-006860-a3b8hyyr	3321	27	of	of	IN
cord-006860-a3b8hyyr	3321	28	the	the	DT
cord-006860-a3b8hyyr	3321	29	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	3321	30	of	of	IN
cord-006860-a3b8hyyr	3321	31	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	3321	32	.	.	.
cord-006860-a3b8hyyr	3322	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3322	2	are	be	VBP
cord-006860-a3b8hyyr	3322	3	currently	currently	RB
cord-006860-a3b8hyyr	3322	4	assessing	assess	VBG
cord-006860-a3b8hyyr	3322	5	the	the	DT
cord-006860-a3b8hyyr	3322	6	role	role	NN
cord-006860-a3b8hyyr	3322	7	of	of	IN
cord-006860-a3b8hyyr	3322	8	spatial	spatial	JJ
cord-006860-a3b8hyyr	3322	9	expression	expression	NN
cord-006860-a3b8hyyr	3322	10	of	of	IN
cord-006860-a3b8hyyr	3322	11	uPA	upa	NN
cord-006860-a3b8hyyr	3322	12	and	and	CC
cord-006860-a3b8hyyr	3322	13	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3322	14	receptor	receptor	NN
cord-006860-a3b8hyyr	3322	15	(	(	-LRB-
cord-006860-a3b8hyyr	3322	16	TR	TR	NNP
cord-006860-a3b8hyyr	3322	17	)	)	-RRB-
cord-006860-a3b8hyyr	3322	18	on	on	IN
cord-006860-a3b8hyyr	3322	19	cells	cell	NNS
cord-006860-a3b8hyyr	3322	20	with	with	IN
cord-006860-a3b8hyyr	3322	21	human	human	JJ
cord-006860-a3b8hyyr	3322	22	carotid	carotid	JJ
cord-006860-a3b8hyyr	3322	23	artery	artery	NN
cord-006860-a3b8hyyr	3322	24	plaques	plaque	NNS
cord-006860-a3b8hyyr	3322	25	(	(	-LRB-
cord-006860-a3b8hyyr	3322	26	n=10	n=10	NNP
cord-006860-a3b8hyyr	3322	27	)	)	-RRB-
cord-006860-a3b8hyyr	3322	28	.	.	.
cord-006860-a3b8hyyr	3323	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3323	2	have	have	VBP
cord-006860-a3b8hyyr	3323	3	used	use	VBN
cord-006860-a3b8hyyr	3323	4	a	a	DT
cord-006860-a3b8hyyr	3323	5	double	double	JJ
cord-006860-a3b8hyyr	3323	6	immunolabeling	immunolabeling	NN
cord-006860-a3b8hyyr	3323	7	approach	approach	NN
cord-006860-a3b8hyyr	3323	8	,	,	,
cord-006860-a3b8hyyr	3323	9	combining	combine	VBG
cord-006860-a3b8hyyr	3323	10	anti	anti	AFX
cord-006860-a3b8hyyr	3323	11	-	-	JJ
cord-006860-a3b8hyyr	3323	12	uPA	upa	JJ
cord-006860-a3b8hyyr	3323	13	and	and	CC
cord-006860-a3b8hyyr	3323	14	anfi	anfi	NN
cord-006860-a3b8hyyr	3323	15	-	-	HYPH
cord-006860-a3b8hyyr	3323	16	TR	tr	NN
cord-006860-a3b8hyyr	3323	17	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3323	18	.	.	.
cord-006860-a3b8hyyr	3324	1	To	to	TO
cord-006860-a3b8hyyr	3324	2	identify	identify	VB
cord-006860-a3b8hyyr	3324	3	the	the	DT
cord-006860-a3b8hyyr	3324	4	different	different	JJ
cord-006860-a3b8hyyr	3324	5	cell	cell	NN
cord-006860-a3b8hyyr	3324	6	types	type	NNS
cord-006860-a3b8hyyr	3324	7	,	,	,
cord-006860-a3b8hyyr	3324	8	we	-PRON-	PRP
cord-006860-a3b8hyyr	3324	9	used	use	VBD
cord-006860-a3b8hyyr	3324	10	the	the	DT
cord-006860-a3b8hyyr	3324	11	following	follow	VBG
cord-006860-a3b8hyyr	3324	12	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3324	13	:	:	:
cord-006860-a3b8hyyr	3324	14	anti	anti	VB
cord-006860-a3b8hyyr	3324	15	a	a	DT
cord-006860-a3b8hyyr	3324	16	-	-	HYPH
cord-006860-a3b8hyyr	3324	17	smooth	smooth	JJ
cord-006860-a3b8hyyr	3324	18	muscle	muscle	NN
cord-006860-a3b8hyyr	3324	19	actin	actin	NN
cord-006860-a3b8hyyr	3324	20	(	(	-LRB-
cord-006860-a3b8hyyr	3324	21	a	a	DT
cord-006860-a3b8hyyr	3324	22	-	-	HYPH
cord-006860-a3b8hyyr	3324	23	SMA	SMA	NNP
cord-006860-a3b8hyyr	3324	24	)	)	-RRB-
cord-006860-a3b8hyyr	3324	25	for	for	IN
cord-006860-a3b8hyyr	3324	26	smooth	smooth	JJ
cord-006860-a3b8hyyr	3324	27	muscle	muscle	NN
cord-006860-a3b8hyyr	3324	28	cells	cell	NNS
cord-006860-a3b8hyyr	3324	29	,	,	,
cord-006860-a3b8hyyr	3324	30	Ulex	Ulex	NNP
cord-006860-a3b8hyyr	3324	31	europaeus	europaeus	NN
cord-006860-a3b8hyyr	3324	32	agglutinin	agglutinin	NNP
cord-006860-a3b8hyyr	3325	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	3325	2	(	(	-LRB-
cord-006860-a3b8hyyr	3325	3	UEA	UEA	NNP
cord-006860-a3b8hyyr	3325	4	I	i	NN
cord-006860-a3b8hyyr	3325	5	)	)	-RRB-
cord-006860-a3b8hyyr	3325	6	for	for	IN
cord-006860-a3b8hyyr	3325	7	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	3325	8	cells	cell	NNS
cord-006860-a3b8hyyr	3325	9	,	,	,
cord-006860-a3b8hyyr	3325	10	inflammation	inflammation	NN
cord-006860-a3b8hyyr	3325	11	cell	cell	NN
cord-006860-a3b8hyyr	3325	12	cocktail	cocktail	NN
cord-006860-a3b8hyyr	3325	13	(	(	-LRB-
cord-006860-a3b8hyyr	3325	14	CD68+CD45	CD68+CD45	NNP
cord-006860-a3b8hyyr	3325	15	)	)	-RRB-
cord-006860-a3b8hyyr	3325	16	for	for	IN
cord-006860-a3b8hyyr	3325	17	monocyte	monocyte	NNP
cord-006860-a3b8hyyr	3325	18	/	/	SYM
cord-006860-a3b8hyyr	3325	19	macrophage	macrophage	NN
cord-006860-a3b8hyyr	3325	20	and	and	CC
cord-006860-a3b8hyyr	3325	21	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	3325	22	and	and	CC
cord-006860-a3b8hyyr	3325	23	an	an	DT
cord-006860-a3b8hyyr	3325	24	anti	anti	JJ
cord-006860-a3b8hyyr	3325	25	-	-	JJ
cord-006860-a3b8hyyr	3325	26	proliferation	proliferation	JJ
cord-006860-a3b8hyyr	3325	27	cell	cell	NN
cord-006860-a3b8hyyr	3325	28	nuclear	nuclear	JJ
cord-006860-a3b8hyyr	3325	29	antigen	antigen	NN
cord-006860-a3b8hyyr	3325	30	antibody	antibody	NN
cord-006860-a3b8hyyr	3325	31	(	(	-LRB-
cord-006860-a3b8hyyr	3325	32	PCNA	PCNA	NNP
cord-006860-a3b8hyyr	3325	33	)	)	-RRB-
cord-006860-a3b8hyyr	3325	34	to	to	TO
cord-006860-a3b8hyyr	3325	35	stain	stain	VB
cord-006860-a3b8hyyr	3325	36	proliferating	proliferate	VBG
cord-006860-a3b8hyyr	3325	37	cells	cell	NNS
cord-006860-a3b8hyyr	3325	38	.	.	.
cord-006860-a3b8hyyr	3326	1	in	in	IN
cord-006860-a3b8hyyr	3326	2	the	the	DT
cord-006860-a3b8hyyr	3326	3	carotid	carotid	JJ
cord-006860-a3b8hyyr	3326	4	atherosclerotic	atherosclerotic	JJ
cord-006860-a3b8hyyr	3326	5	plaques	plaque	NNS
cord-006860-a3b8hyyr	3326	6	,	,	,
cord-006860-a3b8hyyr	3326	7	uPA	upa	NN
cord-006860-a3b8hyyr	3326	8	immunostaining	immunostaine	VBG
cord-006860-a3b8hyyr	3326	9	was	be	VBD
cord-006860-a3b8hyyr	3326	10	distributed	distribute	VBN
cord-006860-a3b8hyyr	3326	11	focally	focally	RB
cord-006860-a3b8hyyr	3326	12	,	,	,
cord-006860-a3b8hyyr	3326	13	preferentially	preferentially	RB
cord-006860-a3b8hyyr	3326	14	in	in	IN
cord-006860-a3b8hyyr	3326	15	the	the	DT
cord-006860-a3b8hyyr	3326	16	fibrous	fibrous	JJ
cord-006860-a3b8hyyr	3326	17	cap	cap	NN
cord-006860-a3b8hyyr	3326	18	and	and	CC
cord-006860-a3b8hyyr	3326	19	some	some	DT
cord-006860-a3b8hyyr	3326	20	cells	cell	NNS
cord-006860-a3b8hyyr	3326	21	of	of	IN
cord-006860-a3b8hyyr	3326	22	the	the	DT
cord-006860-a3b8hyyr	3326	23	foam	foam	NN
cord-006860-a3b8hyyr	3326	24	cell	cell	NN
cord-006860-a3b8hyyr	3326	25	rich	rich	JJ
cord-006860-a3b8hyyr	3326	26	region	region	NN
cord-006860-a3b8hyyr	3326	27	(	(	-LRB-
cord-006860-a3b8hyyr	3326	28	FCRR	FCRR	NNP
cord-006860-a3b8hyyr	3326	29	)	)	-RRB-
cord-006860-a3b8hyyr	3326	30	.	.	.
cord-006860-a3b8hyyr	3327	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	3327	2	was	be	VBD
cord-006860-a3b8hyyr	3327	3	present	present	JJ
cord-006860-a3b8hyyr	3327	4	in	in	IN
cord-006860-a3b8hyyr	3327	5	distinct	distinct	JJ
cord-006860-a3b8hyyr	3327	6	patterns	pattern	NNS
cord-006860-a3b8hyyr	3327	7	:	:	:
cord-006860-a3b8hyyr	3327	8	cytoplasmic	cytoplasmic	JJ
cord-006860-a3b8hyyr	3327	9	staining	staining	NN
cord-006860-a3b8hyyr	3327	10	.	.	.
cord-006860-a3b8hyyr	3328	1	TR	tr	NN
cord-006860-a3b8hyyr	3328	2	staining	staining	NN
cord-006860-a3b8hyyr	3328	3	was	be	VBD
cord-006860-a3b8hyyr	3328	4	distributed	distribute	VBN
cord-006860-a3b8hyyr	3328	5	similar	similar	JJ
cord-006860-a3b8hyyr	3328	6	to	to	IN
cord-006860-a3b8hyyr	3328	7	uPA	upa	NN
cord-006860-a3b8hyyr	3328	8	staining	staining	NN
cord-006860-a3b8hyyr	3328	9	.	.	.
cord-006860-a3b8hyyr	3329	1	With	with	IN
cord-006860-a3b8hyyr	3329	2	double	double	JJ
cord-006860-a3b8hyyr	3329	3	staining	staining	NN
cord-006860-a3b8hyyr	3329	4	combining	combine	VBG
cord-006860-a3b8hyyr	3329	5	anti	anti	NNP
cord-006860-a3b8hyyr	3329	6	uPA	upa	NN
cord-006860-a3b8hyyr	3329	7	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3329	8	with	with	IN
cord-006860-a3b8hyyr	3329	9	anti	anti	JJ
cord-006860-a3b8hyyr	3329	10	-	-	JJ
cord-006860-a3b8hyyr	3329	11	TR	tr	JJ
cord-006860-a3b8hyyr	3329	12	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3329	13	,	,	,
cord-006860-a3b8hyyr	3329	14	cellular	cellular	JJ
cord-006860-a3b8hyyr	3329	15	co	co	NN
cord-006860-a3b8hyyr	3329	16	-	-	NN
cord-006860-a3b8hyyr	3329	17	localisation	localisation	NN
cord-006860-a3b8hyyr	3329	18	of	of	IN
cord-006860-a3b8hyyr	3329	19	both	both	DT
cord-006860-a3b8hyyr	3329	20	uPA	uPA	NNP
cord-006860-a3b8hyyr	3329	21	and	and	CC
cord-006860-a3b8hyyr	3329	22	TR	TR	NNP
cord-006860-a3b8hyyr	3329	23	was	be	VBD
cord-006860-a3b8hyyr	3329	24	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	3329	25	.	.	.
cord-006860-a3b8hyyr	3330	1	These	these	DT
cord-006860-a3b8hyyr	3330	2	cells	cell	NNS
cord-006860-a3b8hyyr	3330	3	were	be	VBD
cord-006860-a3b8hyyr	3330	4	identified	identify	VBN
cord-006860-a3b8hyyr	3330	5	as	as	IN
cord-006860-a3b8hyyr	3330	6	smooth	smooth	JJ
cord-006860-a3b8hyyr	3330	7	muscle	muscle	NN
cord-006860-a3b8hyyr	3330	8	cells	cell	NNS
cord-006860-a3b8hyyr	3330	9	by	by	IN
cord-006860-a3b8hyyr	3330	10	-SMA	-SMA	JJR
cord-006860-a3b8hyyr	3330	11	.	.	.
cord-006860-a3b8hyyr	3331	1	Inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	3331	2	cells	cell	NNS
cord-006860-a3b8hyyr	3331	3	were	be	VBD
cord-006860-a3b8hyyr	3331	4	mainly	mainly	RB
cord-006860-a3b8hyyr	3331	5	localized	localize	VBN
cord-006860-a3b8hyyr	3331	6	within	within	IN
cord-006860-a3b8hyyr	3331	7	the	the	DT
cord-006860-a3b8hyyr	3331	8	FCRR	FCRR	NNP
cord-006860-a3b8hyyr	3331	9	,	,	,
cord-006860-a3b8hyyr	3331	10	they	-PRON-	PRP
cord-006860-a3b8hyyr	3331	11	only	only	RB
cord-006860-a3b8hyyr	3331	12	stained	stain	VBD
cord-006860-a3b8hyyr	3331	13	for	for	IN
cord-006860-a3b8hyyr	3331	14	uPA	upa	NN
cord-006860-a3b8hyyr	3331	15	.	.	.
cord-006860-a3b8hyyr	3332	1	In	in	IN
cord-006860-a3b8hyyr	3332	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	3332	3	:	:	:
cord-006860-a3b8hyyr	3332	4	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	3332	5	data	data	NN
cord-006860-a3b8hyyr	3332	6	demonstrates	demonstrate	VBZ
cord-006860-a3b8hyyr	3332	7	that	that	IN
cord-006860-a3b8hyyr	3332	8	uPA	uPA	NNP
cord-006860-a3b8hyyr	3332	9	and	and	CC
cord-006860-a3b8hyyr	3332	10	TR	TR	NNP
cord-006860-a3b8hyyr	3332	11	are	be	VBP
cord-006860-a3b8hyyr	3332	12	coexpressed	coexpresse	VBN
cord-006860-a3b8hyyr	3332	13	in	in	IN
cord-006860-a3b8hyyr	3332	14	VSMCs	vsmc	NNS
cord-006860-a3b8hyyr	3332	15	in	in	IN
cord-006860-a3b8hyyr	3332	16	human	human	JJ
cord-006860-a3b8hyyr	3332	17	carotid	carotid	JJ
cord-006860-a3b8hyyr	3332	18	artery	artery	NN
cord-006860-a3b8hyyr	3332	19	atherosclerotic	atherosclerotic	JJ
cord-006860-a3b8hyyr	3332	20	plaque	plaque	NN
cord-006860-a3b8hyyr	3332	21	tissue	tissue	NN
cord-006860-a3b8hyyr	3332	22	.	.	.
cord-006860-a3b8hyyr	3333	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3333	2	therefore	therefore	RB
cord-006860-a3b8hyyr	3333	3	conclude	conclude	VBP
cord-006860-a3b8hyyr	3333	4	,	,	,
cord-006860-a3b8hyyr	3333	5	that	that	IN
cord-006860-a3b8hyyr	3333	6	the	the	DT
cord-006860-a3b8hyyr	3333	7	mitogenic	mitogenic	NNP
cord-006860-a3b8hyyr	3333	8	activity	activity	NN
cord-006860-a3b8hyyr	3333	9	of	of	IN
cord-006860-a3b8hyyr	3333	10	uPA	uPA	NNP
cord-006860-a3b8hyyr	3333	11	is	be	VBZ
cord-006860-a3b8hyyr	3333	12	associated	associate	VBN
cord-006860-a3b8hyyr	3333	13	with	with	IN
cord-006860-a3b8hyyr	3333	14	the	the	DT
cord-006860-a3b8hyyr	3333	15	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3333	16	signalling	signal	VBG
cord-006860-a3b8hyyr	3333	17	pathway	pathway	NN
cord-006860-a3b8hyyr	3333	18	.	.	.
cord-006860-a3b8hyyr	3334	1	In	in	IN
cord-006860-a3b8hyyr	3334	2	the	the	DT
cord-006860-a3b8hyyr	3334	3	Proficiency	Proficiency	NNP
cord-006860-a3b8hyyr	3334	4	Test	Test	NNP
cord-006860-a3b8hyyr	3334	5	of	of	IN
cord-006860-a3b8hyyr	3334	6	the	the	DT
cord-006860-a3b8hyyr	3334	7	,	,	,
cord-006860-a3b8hyyr	3334	8	,	,	,
cord-006860-a3b8hyyr	3334	9	Deutsche	Deutsche	NNP
cord-006860-a3b8hyyr	3334	10	Gesellschaft	Gesellschaft	NNP
cord-006860-a3b8hyyr	3334	11	flir	flir	NNP
cord-006860-a3b8hyyr	3334	12	Klinische	Klinische	NNP
cord-006860-a3b8hyyr	3334	13	Chemie	Chemie	NNP
cord-006860-a3b8hyyr	3334	14	"	"	''
cord-006860-a3b8hyyr	3334	15	(	(	-LRB-
cord-006860-a3b8hyyr	3334	16	DGKC	DGKC	NNP
cord-006860-a3b8hyyr	3334	17	)	)	-RRB-
cord-006860-a3b8hyyr	3334	18	1/95	1/95	CD
cord-006860-a3b8hyyr	3334	19	,	,	,
cord-006860-a3b8hyyr	3334	20	5	5	CD
cord-006860-a3b8hyyr	3334	21	lyophilised	lyophilised	JJ
cord-006860-a3b8hyyr	3334	22	plasma	plasma	NN
cord-006860-a3b8hyyr	3334	23	samples	sample	NNS
cord-006860-a3b8hyyr	3334	24	(	(	-LRB-
cord-006860-a3b8hyyr	3334	25	Immuno	Immuno	NNP
cord-006860-a3b8hyyr	3334	26	AG	AG	NNP
cord-006860-a3b8hyyr	3334	27	)	)	-RRB-
cord-006860-a3b8hyyr	3334	28	were	be	VBD
cord-006860-a3b8hyyr	3334	29	sent	send	VBN
cord-006860-a3b8hyyr	3334	30	to	to	IN
cord-006860-a3b8hyyr	3334	31	participants	participant	NNS
cord-006860-a3b8hyyr	3334	32	:	:	:
cord-006860-a3b8hyyr	3334	33	a	a	DT
cord-006860-a3b8hyyr	3334	34	normal	normal	JJ
cord-006860-a3b8hyyr	3334	35	plasma	plasma	NN
cord-006860-a3b8hyyr	3334	36	and	and	CC
cord-006860-a3b8hyyr	3334	37	4	4	CD
cord-006860-a3b8hyyr	3334	38	plasmas	plasma	NNS
cord-006860-a3b8hyyr	3334	39	from	from	IN
cord-006860-a3b8hyyr	3334	40	persons	person	NNS
cord-006860-a3b8hyyr	3334	41	under	under	IN
cord-006860-a3b8hyyr	3334	42	oral	oral	JJ
cord-006860-a3b8hyyr	3334	43	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3334	44	(	(	-LRB-
cord-006860-a3b8hyyr	3334	45	OAC	OAC	NNP
cord-006860-a3b8hyyr	3334	46	-	-	HYPH
cord-006860-a3b8hyyr	3334	47	plasmas	plasma	NNS
cord-006860-a3b8hyyr	3334	48	.	.	.
cord-006860-a3b8hyyr	3335	1	INR	INR	NNP
cord-006860-a3b8hyyr	3335	2	1.9	1.9	CD
cord-006860-a3b8hyyr	3335	3	to	to	IN
cord-006860-a3b8hyyr	3335	4	3.7	3.7	CD
cord-006860-a3b8hyyr	3335	5	)	)	-RRB-
cord-006860-a3b8hyyr	3335	6	.	.	.
cord-006860-a3b8hyyr	3336	1	The	the	DT
cord-006860-a3b8hyyr	3336	2	participants	participant	NNS
cord-006860-a3b8hyyr	3336	3	(	(	-LRB-
cord-006860-a3b8hyyr	3336	4	N=552	N=552	NNP
cord-006860-a3b8hyyr	3336	5	)	)	-RRB-
cord-006860-a3b8hyyr	3336	6	returned	return	VBD
cord-006860-a3b8hyyr	3336	7	the	the	DT
cord-006860-a3b8hyyr	3336	8	PT	PT	NNP
cord-006860-a3b8hyyr	3336	9	times	time	NNS
cord-006860-a3b8hyyr	3336	10	obtained	obtain	VBN
cord-006860-a3b8hyyr	3336	11	and	and	CC
cord-006860-a3b8hyyr	3336	12	in	in	IN
cord-006860-a3b8hyyr	3336	13	most	most	JJS
cord-006860-a3b8hyyr	3336	14	cases	case	NNS
cord-006860-a3b8hyyr	3336	15	(	(	-LRB-
cord-006860-a3b8hyyr	3336	16	N=355	N=355	NNS
cord-006860-a3b8hyyr	3336	17	)	)	-RRB-
cord-006860-a3b8hyyr	3336	18	also	also	RB
cord-006860-a3b8hyyr	3336	19	the	the	DT
cord-006860-a3b8hyyr	3336	20	ISI	ISI	NNP
cord-006860-a3b8hyyr	3336	21	value	value	NN
cord-006860-a3b8hyyr	3336	22	for	for	IN
cord-006860-a3b8hyyr	3336	23	the	the	DT
cord-006860-a3b8hyyr	3336	24	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	3336	25	used	use	VBN
cord-006860-a3b8hyyr	3336	26	(	(	-LRB-
cord-006860-a3b8hyyr	3336	27	ISI	ISI	NNP
cord-006860-a3b8hyyr	3336	28	of	of	IN
cord-006860-a3b8hyyr	3336	29	pack	pack	NN
cord-006860-a3b8hyyr	3336	30	insert	insert	NN
cord-006860-a3b8hyyr	3336	31	)	)	-RRB-
cord-006860-a3b8hyyr	3336	32	.	.	.
cord-006860-a3b8hyyr	3337	1	The	the	DT
cord-006860-a3b8hyyr	3337	2	INR	INR	NNP
cord-006860-a3b8hyyr	3337	3	was	be	VBD
cord-006860-a3b8hyyr	3337	4	calculated	calculate	VBN
cord-006860-a3b8hyyr	3337	5	using	use	VBG
cord-006860-a3b8hyyr	3337	6	the	the	DT
cord-006860-a3b8hyyr	3337	7	PT	PT	NNP
cord-006860-a3b8hyyr	3337	8	of	of	IN
cord-006860-a3b8hyyr	3337	9	normal	normal	JJ
cord-006860-a3b8hyyr	3337	10	plasma	plasma	NN
cord-006860-a3b8hyyr	3337	11	and	and	CC
cord-006860-a3b8hyyr	3337	12	the	the	DT
cord-006860-a3b8hyyr	3337	13	ISI	ISI	NNP
cord-006860-a3b8hyyr	3337	14	of	of	IN
cord-006860-a3b8hyyr	3337	15	pack	pack	NN
cord-006860-a3b8hyyr	3337	16	insert	insert	NN
cord-006860-a3b8hyyr	3337	17	(	(	-LRB-
cord-006860-a3b8hyyr	3337	18	method	method	NN
cord-006860-a3b8hyyr	3337	19	I	I	NNP
cord-006860-a3b8hyyr	3337	20	)	)	-RRB-
cord-006860-a3b8hyyr	3337	21	.	.	.
cord-006860-a3b8hyyr	3338	1	Two	two	CD
cord-006860-a3b8hyyr	3338	2	additional	additional	JJ
cord-006860-a3b8hyyr	3338	3	methods	method	NNS
cord-006860-a3b8hyyr	3338	4	for	for	IN
cord-006860-a3b8hyyr	3338	5	INR	INR	NNP
cord-006860-a3b8hyyr	3338	6	calculation	calculation	NN
cord-006860-a3b8hyyr	3338	7	were	be	VBD
cord-006860-a3b8hyyr	3338	8	compared	compare	VBN
cord-006860-a3b8hyyr	3338	9	with	with	IN
cord-006860-a3b8hyyr	3338	10	method	method	NN
cord-006860-a3b8hyyr	3338	11	I.	i.	NN
cord-006860-a3b8hyyr	3339	1	According	accord	VBG
cord-006860-a3b8hyyr	3339	2	to	to	IN
cord-006860-a3b8hyyr	3339	3	the	the	DT
cord-006860-a3b8hyyr	3339	4	concept	concept	NN
cord-006860-a3b8hyyr	3339	5	of	of	IN
cord-006860-a3b8hyyr	3339	6	calibrated	calibrate	VBN
cord-006860-a3b8hyyr	3339	7	plasmas	plasma	NNS
cord-006860-a3b8hyyr	3339	8	(	(	-LRB-
cord-006860-a3b8hyyr	3339	9	Houbouyan	Houbouyan	NNP
cord-006860-a3b8hyyr	3339	10	et	et	NNP
cord-006860-a3b8hyyr	3339	11	al	al	NNP
cord-006860-a3b8hyyr	3339	12	.	.	NNP
cord-006860-a3b8hyyr	3339	13	,	,	,
cord-006860-a3b8hyyr	3339	14	t993	t993	NNP
cord-006860-a3b8hyyr	3339	15	)	)	-RRB-
cord-006860-a3b8hyyr	3339	16	,	,	,
cord-006860-a3b8hyyr	3339	17	a	a	DT
cord-006860-a3b8hyyr	3339	18	calibration	calibration	NN
cord-006860-a3b8hyyr	3339	19	curve	curve	NN
cord-006860-a3b8hyyr	3339	20	was	be	VBD
cord-006860-a3b8hyyr	3339	21	constructed	construct	VBN
cord-006860-a3b8hyyr	3339	22	using	use	VBG
cord-006860-a3b8hyyr	3339	23	the	the	DT
cord-006860-a3b8hyyr	3339	24	normal	normal	JJ
cord-006860-a3b8hyyr	3339	25	plasma	plasma	NN
cord-006860-a3b8hyyr	3339	26	and	and	CC
cord-006860-a3b8hyyr	3339	27	the	the	DT
cord-006860-a3b8hyyr	3339	28	30AC	30ac	CD
cord-006860-a3b8hyyr	3339	29	-	-	HYPH
cord-006860-a3b8hyyr	3339	30	plasmas	plasma	NNS
cord-006860-a3b8hyyr	3339	31	.	.	.
cord-006860-a3b8hyyr	3340	1	The	the	DT
cord-006860-a3b8hyyr	3340	2	INR	INR	NNP
cord-006860-a3b8hyyr	3340	3	calculated	calculate	VBD
cord-006860-a3b8hyyr	3340	4	using	use	VBG
cord-006860-a3b8hyyr	3340	5	the	the	DT
cord-006860-a3b8hyyr	3340	6	PT	PT	NNP
cord-006860-a3b8hyyr	3340	7	•fn•rma	•fn•rma	NNP
cord-006860-a3b8hyyr	3341	1	¿	¿	NNP
cord-006860-a3b8hyyr	3341	2	plasma	plasma	NNP
cord-006860-a3b8hyyr	3341	3	and	and	CC
cord-006860-a3b8hyyr	3341	4	the	the	DT
cord-006860-a3b8hyyr	3341	5	laboratory	laboratory	NN
cord-006860-a3b8hyyr	3341	6	-	-	HYPH
cord-006860-a3b8hyyr	3341	7	specific	specific	JJ
cord-006860-a3b8hyyr	3341	8	ISI	ISI	NNP
cord-006860-a3b8hyyr	3341	9	value	value	NN
cord-006860-a3b8hyyr	3341	10	given	give	VBN
cord-006860-a3b8hyyr	3341	11	as	as	IN
cord-006860-a3b8hyyr	3341	12	1	1	CD
cord-006860-a3b8hyyr	3341	13	/	/	SYM
cord-006860-a3b8hyyr	3341	14	slope	slope	NN
cord-006860-a3b8hyyr	3341	15	of	of	IN
cord-006860-a3b8hyyr	3341	16	the	the	DT
cord-006860-a3b8hyyr	3341	17	calibration	calibration	NN
cord-006860-a3b8hyyr	3341	18	curve	curve	NN
cord-006860-a3b8hyyr	3341	19	(	(	-LRB-
cord-006860-a3b8hyyr	3341	20	method	method	NN
cord-006860-a3b8hyyr	3341	21	II	II	NNP
cord-006860-a3b8hyyr	3341	22	)	)	-RRB-
cord-006860-a3b8hyyr	3341	23	or	or	CC
cord-006860-a3b8hyyr	3341	24	was	be	VBD
cord-006860-a3b8hyyr	3341	25	read	read	VBN
cord-006860-a3b8hyyr	3341	26	off	off	RP
cord-006860-a3b8hyyr	3341	27	directly	directly	RB
cord-006860-a3b8hyyr	3341	28	(	(	-LRB-
cord-006860-a3b8hyyr	3341	29	method	method	NN
cord-006860-a3b8hyyr	3341	30	HI	HI	NNP
cord-006860-a3b8hyyr	3341	31	)	)	-RRB-
cord-006860-a3b8hyyr	3341	32	.	.	.
cord-006860-a3b8hyyr	3342	1	For	for	IN
cord-006860-a3b8hyyr	3342	2	INR	INR	NNP
cord-006860-a3b8hyyr	3342	3	values	value	NNS
cord-006860-a3b8hyyr	3342	4	,	,	,
cord-006860-a3b8hyyr	3342	5	calculated	calculate	VBN
cord-006860-a3b8hyyr	3342	6	by	by	IN
cord-006860-a3b8hyyr	3342	7	the	the	DT
cord-006860-a3b8hyyr	3342	8	3	3	CD
cord-006860-a3b8hyyr	3342	9	methods	method	NNS
cord-006860-a3b8hyyr	3342	10	from	from	IN
cord-006860-a3b8hyyr	3342	11	the	the	DT
cord-006860-a3b8hyyr	3342	12	participants	participant	NNS
cord-006860-a3b8hyyr	3342	13	data	datum	NNS
cord-006860-a3b8hyyr	3342	14	(	(	-LRB-
cord-006860-a3b8hyyr	3342	15	N=355	N=355	NNP
cord-006860-a3b8hyyr	3342	16	)	)	-RRB-
cord-006860-a3b8hyyr	3342	17	,	,	,
cord-006860-a3b8hyyr	3342	18	outlier	outlier	JJ
cord-006860-a3b8hyyr	3342	19	elimination	elimination	NN
cord-006860-a3b8hyyr	3342	20	(	(	-LRB-
cord-006860-a3b8hyyr	3342	21	2SD	2SD	NNP
cord-006860-a3b8hyyr	3342	22	,	,	,
cord-006860-a3b8hyyr	3342	23	iterative	iterative	JJ
cord-006860-a3b8hyyr	3342	24	)	)	-RRB-
cord-006860-a3b8hyyr	3342	25	was	be	VBD
cord-006860-a3b8hyyr	3342	26	performed	perform	VBN
cord-006860-a3b8hyyr	3342	27	.	.	.
cord-006860-a3b8hyyr	3343	1	The	the	DT
cord-006860-a3b8hyyr	3343	2	INR	INR	NNP
cord-006860-a3b8hyyr	3343	3	mean	mean	JJ
cord-006860-a3b8hyyr	3343	4	values	value	NNS
cord-006860-a3b8hyyr	3343	5	for	for	IN
cord-006860-a3b8hyyr	3343	6	all	all	DT
cord-006860-a3b8hyyr	3343	7	3	3	CD
cord-006860-a3b8hyyr	3343	8	calculation	calculation	NN
cord-006860-a3b8hyyr	3343	9	models	model	NNS
cord-006860-a3b8hyyr	3343	10	remain	remain	VBP
cord-006860-a3b8hyyr	3343	11	in	in	IN
cord-006860-a3b8hyyr	3343	12	a	a	DT
cord-006860-a3b8hyyr	3343	13	narrow	narrow	JJ
cord-006860-a3b8hyyr	3343	14	range	range	NN
cord-006860-a3b8hyyr	3343	15	.	.	.
cord-006860-a3b8hyyr	3344	1	Using	use	VBG
cord-006860-a3b8hyyr	3344	2	calibrated	calibrate	VBN
cord-006860-a3b8hyyr	3344	3	plasmas	plasma	NNS
cord-006860-a3b8hyyr	3344	4	(	(	-LRB-
cord-006860-a3b8hyyr	3344	5	method	method	NN
cord-006860-a3b8hyyr	3344	6	1I	1I	NNP
cord-006860-a3b8hyyr	3344	7	and	and	CC
cord-006860-a3b8hyyr	3344	8	m	m	NNP
cord-006860-a3b8hyyr	3344	9	)	)	-RRB-
cord-006860-a3b8hyyr	3344	10	,	,	,
cord-006860-a3b8hyyr	3344	11	less	less	RBR
cord-006860-a3b8hyyr	3344	12	outlier	outlier	JJ
cord-006860-a3b8hyyr	3344	13	were	be	VBD
cord-006860-a3b8hyyr	3344	14	eliminated	eliminate	VBN
cord-006860-a3b8hyyr	3344	15	and	and	CC
cord-006860-a3b8hyyr	3344	16	CV	CV	NNP
cord-006860-a3b8hyyr	3344	17	's	's	POS
cord-006860-a3b8hyyr	3344	18	obtained	obtain	VBN
cord-006860-a3b8hyyr	3344	19	were	be	VBD
cord-006860-a3b8hyyr	3344	20	smaller	small	JJR
cord-006860-a3b8hyyr	3344	21	than	than	IN
cord-006860-a3b8hyyr	3344	22	using	use	VBG
cord-006860-a3b8hyyr	3344	23	the	the	DT
cord-006860-a3b8hyyr	3344	24	conventional	conventional	JJ
cord-006860-a3b8hyyr	3344	25	procedure	procedure	NN
cord-006860-a3b8hyyr	3344	26	(	(	-LRB-
cord-006860-a3b8hyyr	3344	27	I	i	NN
cord-006860-a3b8hyyr	3344	28	)	)	-RRB-
cord-006860-a3b8hyyr	3344	29	.	.	.
cord-006860-a3b8hyyr	3345	1	Obviously	obviously	RB
cord-006860-a3b8hyyr	3345	2	,	,	,
cord-006860-a3b8hyyr	3345	3	the	the	DT
cord-006860-a3b8hyyr	3345	4	INR	INR	NNP
cord-006860-a3b8hyyr	3345	5	inherited	inherit	VBD
cord-006860-a3b8hyyr	3345	6	problems	problem	NNS
cord-006860-a3b8hyyr	3345	7	,	,	,
cord-006860-a3b8hyyr	3345	8	such	such	JJ
cord-006860-a3b8hyyr	3345	9	as	as	IN
cord-006860-a3b8hyyr	3345	10	accurate	accurate	JJ
cord-006860-a3b8hyyr	3345	11	ISI	ISI	NNP
cord-006860-a3b8hyyr	3345	12	value	value	NN
cord-006860-a3b8hyyr	3345	13	,	,	,
cord-006860-a3b8hyyr	3345	14	PT	PT	NNP
cord-006860-a3b8hyyr	3345	15	value	value	NN
cord-006860-a3b8hyyr	3345	16	of	of	IN
cord-006860-a3b8hyyr	3345	17	normal	normal	JJ
cord-006860-a3b8hyyr	3345	18	plasma	plasma	NN
cord-006860-a3b8hyyr	3345	19	and	and	CC
cord-006860-a3b8hyyr	3345	20	instrument	instrument	NN
cord-006860-a3b8hyyr	3345	21	/	/	SYM
cord-006860-a3b8hyyr	3345	22	laboratory	laboratory	NN
cord-006860-a3b8hyyr	3345	23	influences	influence	NNS
cord-006860-a3b8hyyr	3345	24	on	on	IN
cord-006860-a3b8hyyr	3345	25	ISI	ISI	NNP
cord-006860-a3b8hyyr	3345	26	,	,	,
cord-006860-a3b8hyyr	3345	27	can	can	MD
cord-006860-a3b8hyyr	3345	28	be	be	VB
cord-006860-a3b8hyyr	3345	29	reduced	reduce	VBN
cord-006860-a3b8hyyr	3345	30	using	use	VBG
cord-006860-a3b8hyyr	3345	31	calibrated	calibrate	VBN
cord-006860-a3b8hyyr	3345	32	OAC	OAC	NNP
cord-006860-a3b8hyyr	3345	33	-	-	HYPH
cord-006860-a3b8hyyr	3345	34	plasmas	plasma	NNS
cord-006860-a3b8hyyr	3345	35	.	.	.
cord-006860-a3b8hyyr	3346	1	PRACTICAL	practical	JJ
cord-006860-a3b8hyyr	3346	2	APPROACH	approach	NN
cord-006860-a3b8hyyr	3346	3	AND	and	CC
cord-006860-a3b8hyyr	3346	4	EDUCATIONAL	EDUCATIONAL	NNP
cord-006860-a3b8hyyr	3346	5	CONSIDERA	CONSIDERA	NNP
cord-006860-a3b8hyyr	3346	6	-	-	HYPH
cord-006860-a3b8hyyr	3346	7	TIONS	TIONS	NNP
cord-006860-a3b8hyyr	3346	8	OF	of	IN
cord-006860-a3b8hyyr	3346	9	HOME	home	NN
cord-006860-a3b8hyyr	3346	10	PROTHROMBIN	PROTHROMBIN	NNP
cord-006860-a3b8hyyr	3346	11	TIME	time	NN
cord-006860-a3b8hyyr	3346	12	ESTIMATION	estimation	NN
cord-006860-a3b8hyyr	3346	13	A.	a.	NN
cord-006860-a3b8hyyr	3346	14	Bernardo	Bernardo	NNP
cord-006860-a3b8hyyr	3346	15	,	,	,
cord-006860-a3b8hyyr	3346	16	A.	A.	NNP
cord-006860-a3b8hyyr	3346	17	Bernardo	Bernardo	NNP
cord-006860-a3b8hyyr	3346	18	,	,	,
cord-006860-a3b8hyyr	3346	19	C.	C.	NNP
cord-006860-a3b8hyyr	3346	20	Halhuber	Halhuber	NNP
cord-006860-a3b8hyyr	3346	21	Herz	Herz	NNP
cord-006860-a3b8hyyr	3346	22	-	-	HYPH
cord-006860-a3b8hyyr	3346	23	Kreislauf	Kreislauf	NNP
cord-006860-a3b8hyyr	3346	24	-	-	HYPH
cord-006860-a3b8hyyr	3346	25	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	3346	26	,	,	,
cord-006860-a3b8hyyr	3346	27	Bad	Bad	NNP
cord-006860-a3b8hyyr	3346	28	Berleburg	Berleburg	NNP
cord-006860-a3b8hyyr	3346	29	,	,	,
cord-006860-a3b8hyyr	3347	1	Germany	Germany	NNP
cord-006860-a3b8hyyr	3347	2	Specific	Specific	NNP
cord-006860-a3b8hyyr	3347	3	training	training	NN
cord-006860-a3b8hyyr	3347	4	is	be	VBZ
cord-006860-a3b8hyyr	3347	5	necessary	necessary	JJ
cord-006860-a3b8hyyr	3347	6	for	for	IN
cord-006860-a3b8hyyr	3347	7	the	the	DT
cord-006860-a3b8hyyr	3347	8	patient	patient	NN
cord-006860-a3b8hyyr	3347	9	to	to	TO
cord-006860-a3b8hyyr	3347	10	achieve	achieve	VB
cord-006860-a3b8hyyr	3347	11	reliable	reliable	JJ
cord-006860-a3b8hyyr	3347	12	and	and	CC
cord-006860-a3b8hyyr	3347	13	reproducible	reproducible	JJ
cord-006860-a3b8hyyr	3347	14	results	result	NNS
cord-006860-a3b8hyyr	3347	15	in	in	IN
cord-006860-a3b8hyyr	3347	16	prolhrombin	prolhrombin	NNP
cord-006860-a3b8hyyr	3347	17	time	time	NNP
cord-006860-a3b8hyyr	3347	18	measurement	measurement	NN
cord-006860-a3b8hyyr	3347	19	.	.	.
cord-006860-a3b8hyyr	3348	1	The	the	DT
cord-006860-a3b8hyyr	3348	2	training	training	NN
cord-006860-a3b8hyyr	3348	3	scheme	scheme	NN
cord-006860-a3b8hyyr	3348	4	is	be	VBZ
cord-006860-a3b8hyyr	3348	5	based	base	VBN
cord-006860-a3b8hyyr	3348	6	in	in	IN
cord-006860-a3b8hyyr	3348	7	many	many	JJ
cord-006860-a3b8hyyr	3348	8	respects	respect	NNS
cord-006860-a3b8hyyr	3348	9	on	on	IN
cord-006860-a3b8hyyr	3348	10	experience	experience	NN
cord-006860-a3b8hyyr	3348	11	with	with	IN
cord-006860-a3b8hyyr	3348	12	similar	similar	JJ
cord-006860-a3b8hyyr	3348	13	training	training	NN
cord-006860-a3b8hyyr	3348	14	courses	course	NNS
cord-006860-a3b8hyyr	3348	15	for	for	IN
cord-006860-a3b8hyyr	3348	16	home	home	NN
cord-006860-a3b8hyyr	3348	17	control	control	NN
cord-006860-a3b8hyyr	3348	18	and	and	CC
cord-006860-a3b8hyyr	3348	19	management	management	NN
cord-006860-a3b8hyyr	3348	20	of	of	IN
cord-006860-a3b8hyyr	3348	21	diabetes	diabetes	NN
cord-006860-a3b8hyyr	3348	22	and	and	CC
cord-006860-a3b8hyyr	3348	23	asthma	asthma	NN
cord-006860-a3b8hyyr	3348	24	.	.	.
cord-006860-a3b8hyyr	3349	1	The	the	DT
cord-006860-a3b8hyyr	3349	2	education	education	NN
cord-006860-a3b8hyyr	3349	3	program	program	NN
cord-006860-a3b8hyyr	3349	4	is	be	VBZ
cord-006860-a3b8hyyr	3349	5	divided	divide	VBN
cord-006860-a3b8hyyr	3349	6	into	into	IN
cord-006860-a3b8hyyr	3349	7	a	a	DT
cord-006860-a3b8hyyr	3349	8	theoretical	theoretical	JJ
cord-006860-a3b8hyyr	3349	9	and	and	CC
cord-006860-a3b8hyyr	3349	10	a	a	DT
cord-006860-a3b8hyyr	3349	11	practical	practical	JJ
cord-006860-a3b8hyyr	3349	12	part	part	NN
cord-006860-a3b8hyyr	3349	13	.	.	.
cord-006860-a3b8hyyr	3350	1	The	the	DT
cord-006860-a3b8hyyr	3350	2	theory	theory	NN
cord-006860-a3b8hyyr	3350	3	part	part	NN
cord-006860-a3b8hyyr	3350	4	has	have	VBZ
cord-006860-a3b8hyyr	3350	5	group	group	NN
cord-006860-a3b8hyyr	3350	6	sessions	session	NNS
cord-006860-a3b8hyyr	3350	7	of	of	IN
cord-006860-a3b8hyyr	3350	8	twenty	twenty	CD
cord-006860-a3b8hyyr	3350	9	patients	patient	NNS
cord-006860-a3b8hyyr	3350	10	of	of	IN
cord-006860-a3b8hyyr	3350	11	a	a	DT
cord-006860-a3b8hyyr	3350	12	time	time	NN
cord-006860-a3b8hyyr	3350	13	.	.	.
cord-006860-a3b8hyyr	3351	1	The	the	DT
cord-006860-a3b8hyyr	3351	2	practical	practical	JJ
cord-006860-a3b8hyyr	3351	3	course	course	NN
cord-006860-a3b8hyyr	3351	4	is	be	VBZ
cord-006860-a3b8hyyr	3351	5	reduced	reduce	VBN
cord-006860-a3b8hyyr	3351	6	to	to	IN
cord-006860-a3b8hyyr	3351	7	a	a	DT
cord-006860-a3b8hyyr	3351	8	maximum	maximum	NN
cord-006860-a3b8hyyr	3351	9	of	of	IN
cord-006860-a3b8hyyr	3351	10	five	five	CD
cord-006860-a3b8hyyr	3351	11	patients	patient	NNS
cord-006860-a3b8hyyr	3351	12	.	.	.
cord-006860-a3b8hyyr	3352	1	The	the	DT
cord-006860-a3b8hyyr	3352	2	sessions	session	NNS
cord-006860-a3b8hyyr	3352	3	are	be	VBP
cord-006860-a3b8hyyr	3352	4	conducted	conduct	VBN
cord-006860-a3b8hyyr	3352	5	by	by	IN
cord-006860-a3b8hyyr	3352	6	a	a	DT
cord-006860-a3b8hyyr	3352	7	medical	medical	JJ
cord-006860-a3b8hyyr	3352	8	doctor	doctor	NN
cord-006860-a3b8hyyr	3352	9	and	and	CC
cord-006860-a3b8hyyr	3352	10	by	by	IN
cord-006860-a3b8hyyr	3352	11	specialized	specialized	NNP
cord-006860-a3b8hyyr	3352	12	medicaf	medicaf	NNP
cord-006860-a3b8hyyr	3352	13	/	/	SYM
cord-006860-a3b8hyyr	3352	14	technical	technical	JJ
cord-006860-a3b8hyyr	3352	15	assistants	assistant	NNS
cord-006860-a3b8hyyr	3352	16	.	.	.
cord-006860-a3b8hyyr	3353	1	On	on	IN
cord-006860-a3b8hyyr	3353	2	average	average	JJ
cord-006860-a3b8hyyr	3353	3	eight	eight	CD
cord-006860-a3b8hyyr	3353	4	hours	hour	NNS
cord-006860-a3b8hyyr	3353	5	of	of	IN
cord-006860-a3b8hyyr	3353	6	theoretical	theoretical	JJ
cord-006860-a3b8hyyr	3353	7	education	education	NN
cord-006860-a3b8hyyr	3353	8	and	and	CC
cord-006860-a3b8hyyr	3353	9	two	two	CD
cord-006860-a3b8hyyr	3353	10	hours	hour	NNS
cord-006860-a3b8hyyr	3353	11	of	of	IN
cord-006860-a3b8hyyr	3353	12	practical	practical	JJ
cord-006860-a3b8hyyr	3353	13	training	training	NN
cord-006860-a3b8hyyr	3353	14	are	be	VBP
cord-006860-a3b8hyyr	3353	15	sufficient	sufficient	JJ
cord-006860-a3b8hyyr	3353	16	.	.	.
cord-006860-a3b8hyyr	3354	1	The	the	DT
cord-006860-a3b8hyyr	3354	2	contents	content	NNS
cord-006860-a3b8hyyr	3354	3	of	of	IN
cord-006860-a3b8hyyr	3354	4	the	the	DT
cord-006860-a3b8hyyr	3354	5	theoretical	theoretical	JJ
cord-006860-a3b8hyyr	3354	6	lessons	lesson	NNS
cord-006860-a3b8hyyr	3354	7	are	be	VBP
cord-006860-a3b8hyyr	3354	8	:	:	:
cord-006860-a3b8hyyr	3355	1	•	•	NNP
cord-006860-a3b8hyyr	3355	2	need	need	VBP
cord-006860-a3b8hyyr	3355	3	for	for	IN
cord-006860-a3b8hyyr	3355	4	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3355	5	after	after	IN
cord-006860-a3b8hyyr	3355	6	heart	heart	NN
cord-006860-a3b8hyyr	3355	7	valve	valve	NN
cord-006860-a3b8hyyr	3355	8	replacement	replacement	NN
cord-006860-a3b8hyyr	3355	9	,	,	,
cord-006860-a3b8hyyr	3355	10	•	•	NNP
cord-006860-a3b8hyyr	3356	1	potential	potential	JJ
cord-006860-a3b8hyyr	3356	2	interaction	interaction	NN
cord-006860-a3b8hyyr	3356	3	between	between	IN
cord-006860-a3b8hyyr	3356	4	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	3356	5	and	and	CC
cord-006860-a3b8hyyr	3356	6	other	other	JJ
cord-006860-a3b8hyyr	3356	7	medication	medication	NN
cord-006860-a3b8hyyr	3356	8	,	,	,
cord-006860-a3b8hyyr	3356	9	•	•	NNP
cord-006860-a3b8hyyr	3356	10	accurate	accurate	JJ
cord-006860-a3b8hyyr	3356	11	recording	recording	NN
cord-006860-a3b8hyyr	3356	12	of	of	IN
cord-006860-a3b8hyyr	3356	13	the	the	DT
cord-006860-a3b8hyyr	3356	14	measured	measured	JJ
cord-006860-a3b8hyyr	3356	15	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3356	16	time	time	NN
cord-006860-a3b8hyyr	3356	17	results	result	NNS
cord-006860-a3b8hyyr	3356	18	,	,	,
cord-006860-a3b8hyyr	3357	1	•	•	NNP
cord-006860-a3b8hyyr	3357	2	techniques	technique	NNS
cord-006860-a3b8hyyr	3357	3	of	of	IN
cord-006860-a3b8hyyr	3357	4	prospective	prospective	JJ
cord-006860-a3b8hyyr	3357	5	determination	determination	NN
cord-006860-a3b8hyyr	3357	6	of	of	IN
cord-006860-a3b8hyyr	3357	7	the	the	DT
cord-006860-a3b8hyyr	3357	8	necessary	necessary	JJ
cord-006860-a3b8hyyr	3357	9	amount	amount	NN
cord-006860-a3b8hyyr	3357	10	of	of	IN
cord-006860-a3b8hyyr	3357	11	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3357	12	,	,	,
cord-006860-a3b8hyyr	3357	13	•	•	NN
cord-006860-a3b8hyyr	3357	14	calculation	calculation	NN
cord-006860-a3b8hyyr	3357	15	of	of	IN
cord-006860-a3b8hyyr	3357	16	the	the	DT
cord-006860-a3b8hyyr	3357	17	individual	individual	JJ
cord-006860-a3b8hyyr	3357	18	doses	dose	NNS
cord-006860-a3b8hyyr	3357	19	,	,	,
cord-006860-a3b8hyyr	3357	20	•	•	NN
cord-006860-a3b8hyyr	3357	21	potential	potential	JJ
cord-006860-a3b8hyyr	3357	22	pitfalls	pitfall	NNS
cord-006860-a3b8hyyr	3357	23	and	and	CC
cord-006860-a3b8hyyr	3357	24	mistakes	mistake	NNS
cord-006860-a3b8hyyr	3357	25	,	,	,
cord-006860-a3b8hyyr	3357	26	•	•	NNS
cord-006860-a3b8hyyr	3357	27	corrections	correction	NNS
cord-006860-a3b8hyyr	3357	28	in	in	IN
cord-006860-a3b8hyyr	3357	29	case	case	NN
cord-006860-a3b8hyyr	3357	30	of	of	IN
cord-006860-a3b8hyyr	3357	31	over	over	IN
cord-006860-a3b8hyyr	3357	32	-	-	HYPH
cord-006860-a3b8hyyr	3357	33	and	and	CC
cord-006860-a3b8hyyr	3357	34	under	under	IN
cord-006860-a3b8hyyr	3357	35	-	-	HYPH
cord-006860-a3b8hyyr	3357	36	dosage	dosage	NN
cord-006860-a3b8hyyr	3357	37	,	,	,
cord-006860-a3b8hyyr	3357	38	•	•	NNP
cord-006860-a3b8hyyr	3357	39	early	early	JJ
cord-006860-a3b8hyyr	3357	40	recognition	recognition	NN
cord-006860-a3b8hyyr	3357	41	of	of	IN
cord-006860-a3b8hyyr	3357	42	thromboembelic	thromboembelic	NNP
cord-006860-a3b8hyyr	3357	43	and/or	and/or	CC
cord-006860-a3b8hyyr	3357	44	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3357	45	complications	complication	NNS
cord-006860-a3b8hyyr	3357	46	.	.	.
cord-006860-a3b8hyyr	3358	1	An	an	DT
cord-006860-a3b8hyyr	3358	2	alternative	alternative	NN
cord-006860-a3b8hyyr	3358	3	is	be	VBZ
cord-006860-a3b8hyyr	3358	4	a	a	DT
cord-006860-a3b8hyyr	3358	5	full	full	JJ
cord-006860-a3b8hyyr	3358	6	-	-	HYPH
cord-006860-a3b8hyyr	3358	7	day	day	NN
cord-006860-a3b8hyyr	3358	8	intensive	intensive	JJ
cord-006860-a3b8hyyr	3358	9	course	course	NN
cord-006860-a3b8hyyr	3358	10	which	which	WDT
cord-006860-a3b8hyyr	3358	11	can	can	MD
cord-006860-a3b8hyyr	3358	12	be	be	VB
cord-006860-a3b8hyyr	3358	13	held	hold	VBN
cord-006860-a3b8hyyr	3358	14	during	during	IN
cord-006860-a3b8hyyr	3358	15	the	the	DT
cord-006860-a3b8hyyr	3358	16	weekend	weekend	NN
cord-006860-a3b8hyyr	3358	17	.	.	.
cord-006860-a3b8hyyr	3359	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	3359	2	recently	recently	RB
cord-006860-a3b8hyyr	3359	3	reported	report	VBD
cord-006860-a3b8hyyr	3359	4	(	(	-LRB-
cord-006860-a3b8hyyr	3359	5	1	1	CD
cord-006860-a3b8hyyr	3359	6	)	)	-RRB-
cord-006860-a3b8hyyr	3359	7	observation	observation	NN
cord-006860-a3b8hyyr	3359	8	that	that	IN
cord-006860-a3b8hyyr	3359	9	oral	oral	JJ
cord-006860-a3b8hyyr	3359	10	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3359	11	treatment	treatment	NN
cord-006860-a3b8hyyr	3359	12	causes	cause	VBZ
cord-006860-a3b8hyyr	3359	13	an	an	DT
cord-006860-a3b8hyyr	3359	14	increase	increase	NN
cord-006860-a3b8hyyr	3359	15	of	of	IN
cord-006860-a3b8hyyr	3359	16	heparin	heparin	NN
cord-006860-a3b8hyyr	3359	17	cofactor	cofactor	NN
cord-006860-a3b8hyyr	3359	18	II	II	NNP
cord-006860-a3b8hyyr	3359	19	(	(	-LRB-
cord-006860-a3b8hyyr	3359	20	HC	HC	NNP
cord-006860-a3b8hyyr	3359	21	II	II	NNP
cord-006860-a3b8hyyr	3359	22	)	)	-RRB-
cord-006860-a3b8hyyr	3359	23	activity	activity	NN
cord-006860-a3b8hyyr	3359	24	in	in	IN
cord-006860-a3b8hyyr	3359	25	plasma	plasma	NN
cord-006860-a3b8hyyr	3359	26	is	be	VBZ
cord-006860-a3b8hyyr	3359	27	now	now	RB
cord-006860-a3b8hyyr	3359	28	confirmed	confirm	VBN
cord-006860-a3b8hyyr	3359	29	by	by	IN
cord-006860-a3b8hyyr	3359	30	a	a	DT
cord-006860-a3b8hyyr	3359	31	more	more	RBR
cord-006860-a3b8hyyr	3359	32	extensive	extensive	JJ
cord-006860-a3b8hyyr	3359	33	study	study	NN
cord-006860-a3b8hyyr	3359	34	.	.	.
cord-006860-a3b8hyyr	3360	1	In	in	IN
cord-006860-a3b8hyyr	3360	2	43	43	CD
cord-006860-a3b8hyyr	3360	3	thrombophilic	thrombophilic	JJ
cord-006860-a3b8hyyr	3360	4	patients	patient	NNS
cord-006860-a3b8hyyr	3360	5	who	who	WP
cord-006860-a3b8hyyr	3360	6	were	be	VBD
cord-006860-a3b8hyyr	3360	7	on	on	IN
cord-006860-a3b8hyyr	3360	8	vitamin	vitamin	NN
cord-006860-a3b8hyyr	3360	9	K	K	NNP
cord-006860-a3b8hyyr	3360	10	antagonist	antagonist	NN
cord-006860-a3b8hyyr	3360	11	therapy	therapy	NN
cord-006860-a3b8hyyr	3360	12	(	(	-LRB-
cord-006860-a3b8hyyr	3360	13	Marcumar	Marcumar	NNP
cord-006860-a3b8hyyr	3360	14	R	R	NNP
cord-006860-a3b8hyyr	3360	15	)	)	-RRB-
cord-006860-a3b8hyyr	3360	16	we	-PRON-	PRP
cord-006860-a3b8hyyr	3360	17	found	find	VBD
cord-006860-a3b8hyyr	3360	18	a	a	DT
cord-006860-a3b8hyyr	3360	19	median	median	JJ
cord-006860-a3b8hyyr	3360	20	HC	HC	NNP
cord-006860-a3b8hyyr	3360	21	II	II	NNP
cord-006860-a3b8hyyr	3360	22	level	level	NN
cord-006860-a3b8hyyr	3360	23	of	of	IN
cord-006860-a3b8hyyr	3360	24	142	142	CD
cord-006860-a3b8hyyr	3360	25	%	%	NN
cord-006860-a3b8hyyr	3360	26	as	as	IN
cord-006860-a3b8hyyr	3360	27	compared	compare	VBN
cord-006860-a3b8hyyr	3360	28	to	to	IN
cord-006860-a3b8hyyr	3360	29	119	119	CD
cord-006860-a3b8hyyr	3360	30	%	%	NN
cord-006860-a3b8hyyr	3360	31	for	for	IN
cord-006860-a3b8hyyr	3360	32	72	72	CD
cord-006860-a3b8hyyr	3360	33	thrombophilic	thrombophilic	JJ
cord-006860-a3b8hyyr	3360	34	patients	patient	NNS
cord-006860-a3b8hyyr	3360	35	without	without	IN
cord-006860-a3b8hyyr	3360	36	any	any	DT
cord-006860-a3b8hyyr	3360	37	therapy	therapy	NN
cord-006860-a3b8hyyr	3360	38	(	(	-LRB-
cord-006860-a3b8hyyr	3360	39	p	p	NN
cord-006860-a3b8hyyr	3360	40	<	<	XX
cord-006860-a3b8hyyr	3360	41	0.002	0.002	CD
cord-006860-a3b8hyyr	3360	42	"	"	''
cord-006860-a3b8hyyr	3360	43	)	)	-RRB-
cord-006860-a3b8hyyr	3360	44	and	and	CC
cord-006860-a3b8hyyr	3360	45	104	104	CD
cord-006860-a3b8hyyr	3360	46	%	%	NN
cord-006860-a3b8hyyr	3360	47	for	for	IN
cord-006860-a3b8hyyr	3360	48	59	59	CD
cord-006860-a3b8hyyr	3360	49	healthy	healthy	JJ
cord-006860-a3b8hyyr	3360	50	controls	control	NNS
cord-006860-a3b8hyyr	3360	51	(	(	-LRB-
cord-006860-a3b8hyyr	3360	52	p	p	NN
cord-006860-a3b8hyyr	3360	53	<	<	XX
cord-006860-a3b8hyyr	3360	54	0.001	0.001	CD
cord-006860-a3b8hyyr	3360	55	"	"	''
cord-006860-a3b8hyyr	3360	56	)	)	-RRB-
cord-006860-a3b8hyyr	3360	57	.	.	.
cord-006860-a3b8hyyr	3361	1	Moreover	moreover	RB
cord-006860-a3b8hyyr	3361	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	3361	3	observed	observe	VBD
cord-006860-a3b8hyyr	3361	4	that	that	IN
cord-006860-a3b8hyyr	3361	5	the	the	DT
cord-006860-a3b8hyyr	3361	6	increase	increase	NN
cord-006860-a3b8hyyr	3361	7	of	of	IN
cord-006860-a3b8hyyr	3361	8	HC	HC	NNP
cord-006860-a3b8hyyr	3361	9	II	II	NNP
cord-006860-a3b8hyyr	3361	10	level	level	NN
cord-006860-a3b8hyyr	3361	11	was	be	VBD
cord-006860-a3b8hyyr	3361	12	significantly	significantly	RB
cord-006860-a3b8hyyr	3361	13	correlated	correlate	VBN
cord-006860-a3b8hyyr	3361	14	with	with	IN
cord-006860-a3b8hyyr	3361	15	increasing	increase	VBG
cord-006860-a3b8hyyr	3361	16	INR	INR	NNP
cord-006860-a3b8hyyr	3361	17	-	-	HYPH
cord-006860-a3b8hyyr	3361	18	values	value	NNS
cord-006860-a3b8hyyr	3361	19	(	(	-LRB-
cord-006860-a3b8hyyr	3361	20	r	r	NN
cord-006860-a3b8hyyr	3361	21	=	=	SYM
cord-006860-a3b8hyyr	3361	22	0.63	0.63	CD
cord-006860-a3b8hyyr	3361	23	,	,	,
cord-006860-a3b8hyyr	3361	24	p	p	NN
cord-006860-a3b8hyyr	3361	25	<	<	XX
cord-006860-a3b8hyyr	3361	26	0.001	0.001	CD
cord-006860-a3b8hyyr	3361	27	)	)	-RRB-
cord-006860-a3b8hyyr	3361	28	.	.	.
cord-006860-a3b8hyyr	3362	1	Follow	follow	VB
cord-006860-a3b8hyyr	3362	2	-	-	HYPH
cord-006860-a3b8hyyr	3362	3	up	up	RP
cord-006860-a3b8hyyr	3362	4	observations	observation	NNS
cord-006860-a3b8hyyr	3362	5	on	on	IN
cord-006860-a3b8hyyr	3362	6	some	some	DT
cord-006860-a3b8hyyr	3362	7	patients	patient	NNS
cord-006860-a3b8hyyr	3362	8	showed	show	VBD
cord-006860-a3b8hyyr	3362	9	,	,	,
cord-006860-a3b8hyyr	3362	10	however	however	RB
cord-006860-a3b8hyyr	3362	11	,	,	,
cord-006860-a3b8hyyr	3362	12	clear	clear	JJ
cord-006860-a3b8hyyr	3362	13	differences	difference	NNS
cord-006860-a3b8hyyr	3362	14	in	in	IN
cord-006860-a3b8hyyr	3362	15	the	the	DT
cord-006860-a3b8hyyr	3362	16	levels	level	NNS
cord-006860-a3b8hyyr	3362	17	of	of	IN
cord-006860-a3b8hyyr	3362	18	HC	HC	NNP
cord-006860-a3b8hyyr	3362	19	II	II	NNP
cord-006860-a3b8hyyr	3362	20	activity	activity	NN
cord-006860-a3b8hyyr	3362	21	after	after	IN
cord-006860-a3b8hyyr	3362	22	onset	onset	NN
cord-006860-a3b8hyyr	3362	23	of	of	IN
cord-006860-a3b8hyyr	3362	24	vitamin	vitamin	NN
cord-006860-a3b8hyyr	3362	25	K	K	NNP
cord-006860-a3b8hyyr	3362	26	antagonist	antagonist	NN
cord-006860-a3b8hyyr	3362	27	therapy	therapy	NN
cord-006860-a3b8hyyr	3362	28	.	.	.
cord-006860-a3b8hyyr	3363	1	Thus	thus	RB
cord-006860-a3b8hyyr	3363	2	,	,	,
cord-006860-a3b8hyyr	3363	3	some	some	DT
cord-006860-a3b8hyyr	3363	4	patients	patient	NNS
cord-006860-a3b8hyyr	3363	5	responded	respond	VBD
cord-006860-a3b8hyyr	3363	6	rapidly	rapidly	RB
cord-006860-a3b8hyyr	3363	7	with	with	IN
cord-006860-a3b8hyyr	3363	8	a	a	DT
cord-006860-a3b8hyyr	3363	9	significant	significant	JJ
cord-006860-a3b8hyyr	3363	10	increase	increase	NN
cord-006860-a3b8hyyr	3363	11	in	in	IN
cord-006860-a3b8hyyr	3363	12	activity	activity	NN
cord-006860-a3b8hyyr	3363	13	(	(	-LRB-
cord-006860-a3b8hyyr	3363	14	"	"	``
cord-006860-a3b8hyyr	3363	15	strong	strong	JJ
cord-006860-a3b8hyyr	3363	16	responders	responder	NNS
cord-006860-a3b8hyyr	3363	17	"	"	''
cord-006860-a3b8hyyr	3363	18	)	)	-RRB-
cord-006860-a3b8hyyr	3363	19	while	while	IN
cord-006860-a3b8hyyr	3363	20	others	other	NNS
cord-006860-a3b8hyyr	3363	21	showed	show	VBD
cord-006860-a3b8hyyr	3363	22	only	only	RB
cord-006860-a3b8hyyr	3363	23	slight	slight	JJ
cord-006860-a3b8hyyr	3363	24	changes	change	NNS
cord-006860-a3b8hyyr	3363	25	(	(	-LRB-
cord-006860-a3b8hyyr	3363	26	"	"	``
cord-006860-a3b8hyyr	3363	27	weak	weak	JJ
cord-006860-a3b8hyyr	3363	28	responders	responder	NNS
cord-006860-a3b8hyyr	3363	29	"	"	''
cord-006860-a3b8hyyr	3363	30	)	)	-RRB-
cord-006860-a3b8hyyr	3363	31	.	.	.
cord-006860-a3b8hyyr	3364	1	In	in	IN
cord-006860-a3b8hyyr	3364	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	3364	3	,	,	,
cord-006860-a3b8hyyr	3364	4	the	the	DT
cord-006860-a3b8hyyr	3364	5	determination	determination	NN
cord-006860-a3b8hyyr	3364	6	of	of	IN
cord-006860-a3b8hyyr	3364	7	HC	HC	NNP
cord-006860-a3b8hyyr	3364	8	II	II	NNP
cord-006860-a3b8hyyr	3364	9	activity	activity	NN
cord-006860-a3b8hyyr	3364	10	may	may	MD
cord-006860-a3b8hyyr	3364	11	result	result	VB
cord-006860-a3b8hyyr	3364	12	in	in	IN
cord-006860-a3b8hyyr	3364	13	an	an	DT
cord-006860-a3b8hyyr	3364	14	improved	improved	JJ
cord-006860-a3b8hyyr	3364	15	estimation	estimation	NN
cord-006860-a3b8hyyr	3364	16	of	of	IN
cord-006860-a3b8hyyr	3364	17	the	the	DT
cord-006860-a3b8hyyr	3364	18	risk	risk	NN
cord-006860-a3b8hyyr	3364	19	of	of	IN
cord-006860-a3b8hyyr	3364	20	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3364	21	,	,	,
cord-006860-a3b8hyyr	3364	22	especially	especially	RB
cord-006860-a3b8hyyr	3364	23	in	in	IN
cord-006860-a3b8hyyr	3364	24	high	high	JJ
cord-006860-a3b8hyyr	3364	25	intensity	intensity	NN
cord-006860-a3b8hyyr	3364	26	treated	treat	VBN
cord-006860-a3b8hyyr	3364	27	patients	patient	NNS
cord-006860-a3b8hyyr	3364	28	(	(	-LRB-
cord-006860-a3b8hyyr	3364	29	INR	INR	NNP
cord-006860-a3b8hyyr	3364	30	>	>	XX
cord-006860-a3b8hyyr	3364	31	3.5	3.5	CD
cord-006860-a3b8hyyr	3364	32	)	)	-RRB-
cord-006860-a3b8hyyr	3364	33	.	.	.
cord-006860-a3b8hyyr	3365	1	After	after	IN
cord-006860-a3b8hyyr	3365	2	intracoronary	intracoronary	NN
cord-006860-a3b8hyyr	3365	3	Stent	Stent	NNP
cord-006860-a3b8hyyr	3365	4	implantation	implantation	NN
cord-006860-a3b8hyyr	3365	5	an	an	DT
cord-006860-a3b8hyyr	3365	6	aggressive	aggressive	JJ
cord-006860-a3b8hyyr	3365	7	oral	oral	JJ
cord-006860-a3b8hyyr	3365	8	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3365	9	(	(	-LRB-
cord-006860-a3b8hyyr	3365	10	OAC	OAC	NNP
cord-006860-a3b8hyyr	3365	11	)	)	-RRB-
cord-006860-a3b8hyyr	3365	12	therapy	therapy	NN
cord-006860-a3b8hyyr	3365	13	is	be	VBZ
cord-006860-a3b8hyyr	3365	14	mandatory	mandatory	JJ
cord-006860-a3b8hyyr	3365	15	.	.	.
cord-006860-a3b8hyyr	3366	1	To	to	TO
cord-006860-a3b8hyyr	3366	2	find	find	VB
cord-006860-a3b8hyyr	3366	3	out	out	RP
cord-006860-a3b8hyyr	3366	4	whether	whether	IN
cord-006860-a3b8hyyr	3366	5	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3366	6	activation	activation	NN
cord-006860-a3b8hyyr	3366	7	occurs	occur	VBZ
cord-006860-a3b8hyyr	3366	8	after	after	IN
cord-006860-a3b8hyyr	3366	9	coronary	coronary	JJ
cord-006860-a3b8hyyr	3366	10	stent	stent	NN
cord-006860-a3b8hyyr	3366	11	implantation	implantation	NN
cord-006860-a3b8hyyr	3366	12	during	during	IN
cord-006860-a3b8hyyr	3366	13	high	high	JJ
cord-006860-a3b8hyyr	3366	14	dose	dose	NN
cord-006860-a3b8hyyr	3366	15	OAC	OAC	NNP
cord-006860-a3b8hyyr	3366	16	therapy	therapy	NN
cord-006860-a3b8hyyr	3366	17	markers	marker	NNS
cord-006860-a3b8hyyr	3366	18	of	of	IN
cord-006860-a3b8hyyr	3366	19	plasmatic	plasmatic	JJ
cord-006860-a3b8hyyr	3366	20	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3366	21	and	and	CC
cord-006860-a3b8hyyr	3366	22	D	D	NNP
cord-006860-a3b8hyyr	3366	23	-	-	HYPH
cord-006860-a3b8hyyr	3366	24	Dimer	Dimer	NNP
cord-006860-a3b8hyyr	3366	25	were	be	VBD
cord-006860-a3b8hyyr	3366	26	measured	measure	VBN
cord-006860-a3b8hyyr	3366	27	.	.	.
cord-006860-a3b8hyyr	3367	1	Patients	patient	NNS
cord-006860-a3b8hyyr	3367	2	5	5	CD
cord-006860-a3b8hyyr	3367	3	male	male	JJ
cord-006860-a3b8hyyr	3367	4	patients	patient	NNS
cord-006860-a3b8hyyr	3367	5	(	(	-LRB-
cord-006860-a3b8hyyr	3367	6	average	average	JJ
cord-006860-a3b8hyyr	3367	7	age	age	NN
cord-006860-a3b8hyyr	3367	8	57	57	CD
cord-006860-a3b8hyyr	3367	9	years	year	NNS
cord-006860-a3b8hyyr	3367	10	)	)	-RRB-
cord-006860-a3b8hyyr	3367	11	were	be	VBD
cord-006860-a3b8hyyr	3367	12	examined	examine	VBN
cord-006860-a3b8hyyr	3367	13	.	.	.
cord-006860-a3b8hyyr	3368	1	Blood	blood	NN
cord-006860-a3b8hyyr	3368	2	samples	sample	NNS
cord-006860-a3b8hyyr	3368	3	were	be	VBD
cord-006860-a3b8hyyr	3368	4	taken	take	VBN
cord-006860-a3b8hyyr	3368	5	before	before	RB
cord-006860-a3b8hyyr	3368	6	and	and	CC
cord-006860-a3b8hyyr	3368	7	right	right	RB
cord-006860-a3b8hyyr	3368	8	after	after	IN
cord-006860-a3b8hyyr	3368	9	stent	stent	JJ
cord-006860-a3b8hyyr	3368	10	implantation	implantation	NN
cord-006860-a3b8hyyr	3368	11	and	and	CC
cord-006860-a3b8hyyr	3368	12	during	during	IN
cord-006860-a3b8hyyr	3368	13	the	the	DT
cord-006860-a3b8hyyr	3368	14	following	following	JJ
cord-006860-a3b8hyyr	3368	15	week	week	NN
cord-006860-a3b8hyyr	3368	16	.	.	.
cord-006860-a3b8hyyr	3369	1	Patients	patient	NNS
cord-006860-a3b8hyyr	3369	2	got	get	VBD
cord-006860-a3b8hyyr	3369	3	30	30	CD
cord-006860-a3b8hyyr	3369	4	mg	mg	NN
cord-006860-a3b8hyyr	3369	5	phenprocoumon	phenprocoumon	NNP
cord-006860-a3b8hyyr	3369	6	during	during	IN
cord-006860-a3b8hyyr	3369	7	the	the	DT
cord-006860-a3b8hyyr	3369	8	first	first	JJ
cord-006860-a3b8hyyr	3369	9	three	three	CD
cord-006860-a3b8hyyr	3369	10	days	day	NNS
cord-006860-a3b8hyyr	3369	11	and	and	CC
cord-006860-a3b8hyyr	3369	12	additionally	additionally	RB
cord-006860-a3b8hyyr	3369	13	heparin	heparin	JJ
cord-006860-a3b8hyyr	3369	14	and	and	CC
cord-006860-a3b8hyyr	3369	15	acetylsalicylic	acetylsalicylic	JJ
cord-006860-a3b8hyyr	3369	16	acid	acid	NN
cord-006860-a3b8hyyr	3369	17	(	(	-LRB-
cord-006860-a3b8hyyr	3369	18	ASA	ASA	NNP
cord-006860-a3b8hyyr	3369	19	)	)	-RRB-
cord-006860-a3b8hyyr	3369	20	were	be	VBD
cord-006860-a3b8hyyr	3369	21	given	give	VBN
cord-006860-a3b8hyyr	3369	22	.	.	.
cord-006860-a3b8hyyr	3370	1	Methods	method	NNS
cord-006860-a3b8hyyr	3370	2	PTZ	PTZ	NNP
cord-006860-a3b8hyyr	3370	3	,	,	,
cord-006860-a3b8hyyr	3370	4	aPTT	aptt	CD
cord-006860-a3b8hyyr	3370	5	,	,	,
cord-006860-a3b8hyyr	3371	1	TZ	TZ	NNP
cord-006860-a3b8hyyr	3371	2	,	,	,
cord-006860-a3b8hyyr	3371	3	protein	protein	NN
cord-006860-a3b8hyyr	3371	4	C	c	NN
cord-006860-a3b8hyyr	3371	5	,	,	,
cord-006860-a3b8hyyr	3371	6	TAT	tat	NN
cord-006860-a3b8hyyr	3371	7	-	-	HYPH
cord-006860-a3b8hyyr	3371	8	complexes	complex	NNS
cord-006860-a3b8hyyr	3371	9	,	,	,
cord-006860-a3b8hyyr	3371	10	FI+2	FI+2	NNP
cord-006860-a3b8hyyr	3371	11	and	and	CC
cord-006860-a3b8hyyr	3371	12	D	D	NNP
cord-006860-a3b8hyyr	3371	13	-	-	HYPH
cord-006860-a3b8hyyr	3371	14	Dimer	Dimer	NNP
cord-006860-a3b8hyyr	3371	15	were	be	VBD
cord-006860-a3b8hyyr	3371	16	measured	measure	VBN
cord-006860-a3b8hyyr	3371	17	.	.	.
cord-006860-a3b8hyyr	3372	1	Results	result	NNS
cord-006860-a3b8hyyr	3372	2	D	D	NNP
cord-006860-a3b8hyyr	3372	3	-	-	HYPH
cord-006860-a3b8hyyr	3372	4	Dimer	Dimer	NNP
cord-006860-a3b8hyyr	3372	5	levels	level	NNS
cord-006860-a3b8hyyr	3372	6	increased	increase	VBD
cord-006860-a3b8hyyr	3372	7	steadily	steadily	RB
cord-006860-a3b8hyyr	3372	8	between	between	IN
cord-006860-a3b8hyyr	3372	9	day	day	NN
cord-006860-a3b8hyyr	3372	10	0	0	CD
cord-006860-a3b8hyyr	3372	11	and	and	CC
cord-006860-a3b8hyyr	3372	12	day	day	NN
cord-006860-a3b8hyyr	3372	13	7	7	CD
cord-006860-a3b8hyyr	3372	14	.	.	.
cord-006860-a3b8hyyr	3373	1	TATcomplexes	TATcomplexes	NNP
cord-006860-a3b8hyyr	3373	2	showed	show	VBD
cord-006860-a3b8hyyr	3373	3	a	a	DT
cord-006860-a3b8hyyr	3373	4	slight	slight	JJ
cord-006860-a3b8hyyr	3373	5	increase	increase	NN
cord-006860-a3b8hyyr	3373	6	from	from	IN
cord-006860-a3b8hyyr	3373	7	day	day	NN
cord-006860-a3b8hyyr	3373	8	0	0	CD
cord-006860-a3b8hyyr	3373	9	(	(	-LRB-
cord-006860-a3b8hyyr	3373	10	2.4	2.4	CD
cord-006860-a3b8hyyr	3373	11	Bg	Bg	NNP
cord-006860-a3b8hyyr	3373	12	/	/	SYM
cord-006860-a3b8hyyr	3373	13	I	i	NN
cord-006860-a3b8hyyr	3373	14	)	)	-RRB-
cord-006860-a3b8hyyr	3373	15	to	to	IN
cord-006860-a3b8hyyr	3373	16	day	day	NN
cord-006860-a3b8hyyr	3373	17	3	3	CD
cord-006860-a3b8hyyr	3373	18	(	(	-LRB-
cord-006860-a3b8hyyr	3373	19	15.3	15.3	CD
cord-006860-a3b8hyyr	3373	20	~tg	~tg	NNS
cord-006860-a3b8hyyr	3373	21	/	/	SYM
cord-006860-a3b8hyyr	3373	22	I	i	NN
cord-006860-a3b8hyyr	3373	23	)	)	-RRB-
cord-006860-a3b8hyyr	3373	24	.	.	.
cord-006860-a3b8hyyr	3374	1	On	on	IN
cord-006860-a3b8hyyr	3374	2	day	day	NN
cord-006860-a3b8hyyr	3374	3	7	7	CD
cord-006860-a3b8hyyr	3374	4	TAT	tat	NN
cord-006860-a3b8hyyr	3374	5	levels	level	NNS
cord-006860-a3b8hyyr	3374	6	were	be	VBD
cord-006860-a3b8hyyr	3374	7	down	down	RB
cord-006860-a3b8hyyr	3374	8	again	again	RB
cord-006860-a3b8hyyr	3374	9	(	(	-LRB-
cord-006860-a3b8hyyr	3374	10	2.0	2.0	CD
cord-006860-a3b8hyyr	3374	11	p	p	NN
cord-006860-a3b8hyyr	3374	12	,	,	,
cord-006860-a3b8hyyr	3374	13	g	g	NN
cord-006860-a3b8hyyr	3374	14	/	/	SYM
cord-006860-a3b8hyyr	3374	15	l	l	NN
cord-006860-a3b8hyyr	3374	16	)	)	-RRB-
cord-006860-a3b8hyyr	3374	17	.	.	.
cord-006860-a3b8hyyr	3375	1	Fl+2	Fl+2	NNP
cord-006860-a3b8hyyr	3375	2	(	(	-LRB-
cord-006860-a3b8hyyr	3375	3	day	day	NN
cord-006860-a3b8hyyr	3375	4	0:1.0	0:1.0	CD
cord-006860-a3b8hyyr	3375	5	ng	ng	NNP
cord-006860-a3b8hyyr	3375	6	/	/	SYM
cord-006860-a3b8hyyr	3375	7	ml	ml	NN
cord-006860-a3b8hyyr	3375	8	)	)	-RRB-
cord-006860-a3b8hyyr	3375	9	also	also	RB
cord-006860-a3b8hyyr	3375	10	showed	show	VBD
cord-006860-a3b8hyyr	3375	11	a	a	DT
cord-006860-a3b8hyyr	3375	12	slight	slight	JJ
cord-006860-a3b8hyyr	3375	13	increase	increase	NN
cord-006860-a3b8hyyr	3375	14	on	on	IN
cord-006860-a3b8hyyr	3375	15	day	day	NN
cord-006860-a3b8hyyr	3375	16	3	3	CD
cord-006860-a3b8hyyr	3375	17	(	(	-LRB-
cord-006860-a3b8hyyr	3375	18	1.3	1.3	CD
cord-006860-a3b8hyyr	3375	19	ng	ng	NN
cord-006860-a3b8hyyr	3375	20	/	/	SYM
cord-006860-a3b8hyyr	3375	21	ml	ml	NN
cord-006860-a3b8hyyr	3375	22	)	)	-RRB-
cord-006860-a3b8hyyr	3375	23	.	.	.
cord-006860-a3b8hyyr	3376	1	Protein	protein	NN
cord-006860-a3b8hyyr	3376	2	C	C	NNP
cord-006860-a3b8hyyr	3376	3	decreased	decrease	VBD
cord-006860-a3b8hyyr	3376	4	steadily	steadily	RB
cord-006860-a3b8hyyr	3376	5	from	from	IN
cord-006860-a3b8hyyr	3376	6	day	day	NN
cord-006860-a3b8hyyr	3376	7	0	0	CD
cord-006860-a3b8hyyr	3376	8	(	(	-LRB-
cord-006860-a3b8hyyr	3376	9	108	108	CD
cord-006860-a3b8hyyr	3376	10	%	%	NN
cord-006860-a3b8hyyr	3376	11	)	)	-RRB-
cord-006860-a3b8hyyr	3376	12	to	to	IN
cord-006860-a3b8hyyr	3376	13	day	day	NN
cord-006860-a3b8hyyr	3376	14	7	7	CD
cord-006860-a3b8hyyr	3376	15	(	(	-LRB-
cord-006860-a3b8hyyr	3376	16	15	15	CD
cord-006860-a3b8hyyr	3376	17	%	%	NN
cord-006860-a3b8hyyr	3376	18	)	)	-RRB-
cord-006860-a3b8hyyr	3376	19	.	.	.
cord-006860-a3b8hyyr	3377	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	3377	2	During	during	IN
cord-006860-a3b8hyyr	3377	3	the	the	DT
cord-006860-a3b8hyyr	3377	4	initial	initial	JJ
cord-006860-a3b8hyyr	3377	5	phase	phase	NN
cord-006860-a3b8hyyr	3377	6	of	of	IN
cord-006860-a3b8hyyr	3377	7	OAC	OAC	NNP
cord-006860-a3b8hyyr	3377	8	therapy	therapy	NN
cord-006860-a3b8hyyr	3377	9	a	a	DT
cord-006860-a3b8hyyr	3377	10	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3377	11	activation	activation	NN
cord-006860-a3b8hyyr	3377	12	is	be	VBZ
cord-006860-a3b8hyyr	3377	13	reported	report	VBN
cord-006860-a3b8hyyr	3377	14	but	but	CC
cord-006860-a3b8hyyr	3377	15	no	no	DT
cord-006860-a3b8hyyr	3377	16	significant	significant	JJ
cord-006860-a3b8hyyr	3377	17	elevation	elevation	NN
cord-006860-a3b8hyyr	3377	18	of	of	IN
cord-006860-a3b8hyyr	3377	19	TAT	TAT	NNP
cord-006860-a3b8hyyr	3377	20	or	or	CC
cord-006860-a3b8hyyr	3377	21	Fl+2	Fl+2	NNP
cord-006860-a3b8hyyr	3377	22	was	be	VBD
cord-006860-a3b8hyyr	3377	23	found	find	VBN
cord-006860-a3b8hyyr	3377	24	.	.	.
cord-006860-a3b8hyyr	3378	1	This	this	DT
cord-006860-a3b8hyyr	3378	2	result	result	NN
cord-006860-a3b8hyyr	3378	3	shows	show	VBZ
cord-006860-a3b8hyyr	3378	4	that	that	IN
cord-006860-a3b8hyyr	3378	5	additional	additional	JJ
cord-006860-a3b8hyyr	3378	6	heparin	heparin	NN
cord-006860-a3b8hyyr	3378	7	and	and	CC
cord-006860-a3b8hyyr	3378	8	ASA	ASA	NNP
cord-006860-a3b8hyyr	3378	9	therapy	therapy	NN
cord-006860-a3b8hyyr	3378	10	was	be	VBD
cord-006860-a3b8hyyr	3378	11	sufficient	sufficient	JJ
cord-006860-a3b8hyyr	3378	12	to	to	TO
cord-006860-a3b8hyyr	3378	13	avoid	avoid	VB
cord-006860-a3b8hyyr	3378	14	systemic	systemic	JJ
cord-006860-a3b8hyyr	3378	15	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3378	16	activation	activation	NN
cord-006860-a3b8hyyr	3378	17	.	.	.
cord-006860-a3b8hyyr	3379	1	The	the	DT
cord-006860-a3b8hyyr	3379	2	increase	increase	NN
cord-006860-a3b8hyyr	3379	3	of	of	IN
cord-006860-a3b8hyyr	3379	4	D	d	NN
cord-006860-a3b8hyyr	3379	5	-	-	:
cord-006860-a3b8hyyr	3379	6	Direct	direct	JJ
cord-006860-a3b8hyyr	3379	7	should	should	MD
cord-006860-a3b8hyyr	3379	8	be	be	VB
cord-006860-a3b8hyyr	3379	9	interpreted	interpret	VBN
cord-006860-a3b8hyyr	3379	10	as	as	IN
cord-006860-a3b8hyyr	3379	11	a	a	DT
cord-006860-a3b8hyyr	3379	12	si~=m	si~=m	NNP
cord-006860-a3b8hyyr	3379	13	of	of	IN
cord-006860-a3b8hyyr	3379	14	local	local	JJ
cord-006860-a3b8hyyr	3379	15	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	3379	16	reaction	reaction	NN
cord-006860-a3b8hyyr	3379	17	due	due	IN
cord-006860-a3b8hyyr	3379	18	to	to	IN
cord-006860-a3b8hyyr	3379	19	stent	stent	JJ
cord-006860-a3b8hyyr	3379	20	implantation	implantation	NN
cord-006860-a3b8hyyr	3379	21	.	.	.
cord-006860-a3b8hyyr	3380	1	Three	three	CD
cord-006860-a3b8hyyr	3380	2	methods	method	NNS
cord-006860-a3b8hyyr	3380	3	for	for	IN
cord-006860-a3b8hyyr	3380	4	the	the	DT
cord-006860-a3b8hyyr	3380	5	determination	determination	NN
cord-006860-a3b8hyyr	3380	6	of	of	IN
cord-006860-a3b8hyyr	3380	7	Prothrombin	Prothrombin	NNP
cord-006860-a3b8hyyr	3380	8	Time	Time	NNP
cord-006860-a3b8hyyr	3380	9	from	from	IN
cord-006860-a3b8hyyr	3380	10	capillary	capillary	JJ
cord-006860-a3b8hyyr	3380	11	blood	blood	NN
cord-006860-a3b8hyyr	3380	12	in	in	IN
cord-006860-a3b8hyyr	3380	13	patients	patient	NNS
cord-006860-a3b8hyyr	3380	14	under	under	IN
cord-006860-a3b8hyyr	3380	15	oral	oral	JJ
cord-006860-a3b8hyyr	3380	16	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3380	17	have	have	VBP
cord-006860-a3b8hyyr	3380	18	been	be	VBN
cord-006860-a3b8hyyr	3380	19	investigated	investigate	VBN
cord-006860-a3b8hyyr	3380	20	.	.	.
cord-006860-a3b8hyyr	3381	1	Two	two	CD
cord-006860-a3b8hyyr	3381	2	methods	method	NNS
cord-006860-a3b8hyyr	3381	3	were	be	VBD
cord-006860-a3b8hyyr	3381	4	run	run	VBN
cord-006860-a3b8hyyr	3381	5	on	on	IN
cord-006860-a3b8hyyr	3381	6	CoaguChek	CoaguChek	NNP
cord-006860-a3b8hyyr	3381	7	®	®	POS
cord-006860-a3b8hyyr	3381	8	monitors	monitor	NNS
cord-006860-a3b8hyyr	3381	9	(	(	-LRB-
cord-006860-a3b8hyyr	3381	10	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	3381	11	Mannheim	Mannheim	NNP
cord-006860-a3b8hyyr	3381	12	)	)	-RRB-
cord-006860-a3b8hyyr	3381	13	from	from	IN
cord-006860-a3b8hyyr	3381	14	capillary	capillary	JJ
cord-006860-a3b8hyyr	3381	15	whole	whole	JJ
cord-006860-a3b8hyyr	3381	16	blood	blood	NN
cord-006860-a3b8hyyr	3381	17	.	.	.
cord-006860-a3b8hyyr	3382	1	After	after	IN
cord-006860-a3b8hyyr	3382	2	fingerpuncture	fingerpuncture	NNP
cord-006860-a3b8hyyr	3382	3	the	the	DT
cord-006860-a3b8hyyr	3382	4	first	first	JJ
cord-006860-a3b8hyyr	3382	5	drop	drop	NN
cord-006860-a3b8hyyr	3382	6	of	of	IN
cord-006860-a3b8hyyr	3382	7	blood	blood	NN
cord-006860-a3b8hyyr	3382	8	was	be	VBD
cord-006860-a3b8hyyr	3382	9	applied	apply	VBN
cord-006860-a3b8hyyr	3382	10	to	to	IN
cord-006860-a3b8hyyr	3382	11	the	the	DT
cord-006860-a3b8hyyr	3382	12	well	well	NN
cord-006860-a3b8hyyr	3382	13	of	of	IN
cord-006860-a3b8hyyr	3382	14	a	a	DT
cord-006860-a3b8hyyr	3382	15	CoaguChek	CoaguChek	NNP
cord-006860-a3b8hyyr	3382	16	®	®	POS
cord-006860-a3b8hyyr	3382	17	test	test	NN
cord-006860-a3b8hyyr	3382	18	strip	strip	NN
cord-006860-a3b8hyyr	3382	19	directly	directly	RB
cord-006860-a3b8hyyr	3382	20	from	from	IN
cord-006860-a3b8hyyr	3382	21	the	the	DT
cord-006860-a3b8hyyr	3382	22	finger	finger	NN
cord-006860-a3b8hyyr	3382	23	-	-	HYPH
cord-006860-a3b8hyyr	3382	24	tip	tip	NN
cord-006860-a3b8hyyr	3382	25	,	,	,
cord-006860-a3b8hyyr	3382	26	whereas	whereas	IN
cord-006860-a3b8hyyr	3382	27	the	the	DT
cord-006860-a3b8hyyr	3382	28	second	second	JJ
cord-006860-a3b8hyyr	3382	29	drop	drop	NN
cord-006860-a3b8hyyr	3382	30	was	be	VBD
cord-006860-a3b8hyyr	3382	31	sucked	suck	VBN
cord-006860-a3b8hyyr	3382	32	into	into	IN
cord-006860-a3b8hyyr	3382	33	a	a	DT
cord-006860-a3b8hyyr	3382	34	non	non	JJ
cord-006860-a3b8hyyr	3382	35	-	-	JJ
cord-006860-a3b8hyyr	3382	36	anticoagulated	anticoagulated	JJ
cord-006860-a3b8hyyr	3382	37	plastic	plastic	NN
cord-006860-a3b8hyyr	3382	38	capillary	capillary	NN
cord-006860-a3b8hyyr	3382	39	(	(	-LRB-
cord-006860-a3b8hyyr	3382	40	Hirschmann	Hirschmann	NNP
cord-006860-a3b8hyyr	3382	41	)	)	-RRB-
cord-006860-a3b8hyyr	3382	42	and	and	CC
cord-006860-a3b8hyyr	3382	43	immediately	immediately	RB
cord-006860-a3b8hyyr	3382	44	applied	apply	VBD
cord-006860-a3b8hyyr	3382	45	to	to	IN
cord-006860-a3b8hyyr	3382	46	the	the	DT
cord-006860-a3b8hyyr	3382	47	test	test	NN
cord-006860-a3b8hyyr	3382	48	strip	strip	NN
cord-006860-a3b8hyyr	3382	49	-and	-and	CC
cord-006860-a3b8hyyr	3382	50	vice	vice	NN
cord-006860-a3b8hyyr	3382	51	versa	versa	RB
cord-006860-a3b8hyyr	3382	52	to	to	TO
cord-006860-a3b8hyyr	3382	53	eliminate	eliminate	VB
cord-006860-a3b8hyyr	3382	54	any	any	DT
cord-006860-a3b8hyyr	3382	55	influence	influence	NN
cord-006860-a3b8hyyr	3382	56	of	of	IN
cord-006860-a3b8hyyr	3382	57	first	first	JJ
cord-006860-a3b8hyyr	3382	58	and	and	CC
cord-006860-a3b8hyyr	3382	59	second	second	JJ
cord-006860-a3b8hyyr	3382	60	drop	drop	NN
cord-006860-a3b8hyyr	3382	61	of	of	IN
cord-006860-a3b8hyyr	3382	62	blood	blood	NN
cord-006860-a3b8hyyr	3382	63	.	.	.
cord-006860-a3b8hyyr	3383	1	The	the	DT
cord-006860-a3b8hyyr	3383	2	third	third	JJ
cord-006860-a3b8hyyr	3383	3	method	method	NN
cord-006860-a3b8hyyr	3383	4	was	be	VBD
cord-006860-a3b8hyyr	3383	5	Hepato	Hepato	NNP
cord-006860-a3b8hyyr	3383	6	Quick	quick	JJ
cord-006860-a3b8hyyr	3383	7	(	(	-LRB-
cord-006860-a3b8hyyr	3383	8	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	3383	9	Mannheim	Mannheim	NNP
cord-006860-a3b8hyyr	3383	10	)	)	-RRB-
cord-006860-a3b8hyyr	3383	11	which	which	WDT
cord-006860-a3b8hyyr	3383	12	was	be	VBD
cord-006860-a3b8hyyr	3383	13	determined	determine	VBN
cord-006860-a3b8hyyr	3383	14	out	out	IN
cord-006860-a3b8hyyr	3383	15	of	of	IN
cord-006860-a3b8hyyr	3383	16	citrated	citrate	VBN
cord-006860-a3b8hyyr	3383	17	capillary	capillary	JJ
cord-006860-a3b8hyyr	3383	18	blood	blood	NN
cord-006860-a3b8hyyr	3383	19	from	from	IN
cord-006860-a3b8hyyr	3383	20	an	an	DT
cord-006860-a3b8hyyr	3383	21	earlappuncture	earlappuncture	NN
cord-006860-a3b8hyyr	3383	22	.	.	.
cord-006860-a3b8hyyr	3384	1	66	66	CD
cord-006860-a3b8hyyr	3384	2	specimen	specimen	NN
cord-006860-a3b8hyyr	3384	3	of	of	IN
cord-006860-a3b8hyyr	3384	4	patients	patient	NNS
cord-006860-a3b8hyyr	3384	5	under	under	IN
cord-006860-a3b8hyyr	3384	6	oral	oral	JJ
cord-006860-a3b8hyyr	3384	7	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3384	8	were	be	VBD
cord-006860-a3b8hyyr	3384	9	investigated	investigate	VBN
cord-006860-a3b8hyyr	3384	10	.	.	.
cord-006860-a3b8hyyr	3385	1	The	the	DT
cord-006860-a3b8hyyr	3385	2	method	method	NN
cord-006860-a3b8hyyr	3385	3	comparisons	comparison	NNS
cord-006860-a3b8hyyr	3385	4	between	between	IN
cord-006860-a3b8hyyr	3385	5	each	each	DT
cord-006860-a3b8hyyr	3385	6	of	of	IN
cord-006860-a3b8hyyr	3385	7	the	the	DT
cord-006860-a3b8hyyr	3385	8	CoaguChek	CoaguChek	NNP
cord-006860-a3b8hyyr	3385	9	®	®	POS
cord-006860-a3b8hyyr	3385	10	methods	method	NNS
cord-006860-a3b8hyyr	3385	11	and	and	CC
cord-006860-a3b8hyyr	3385	12	the	the	DT
cord-006860-a3b8hyyr	3385	13	laboratory	laboratory	NN
cord-006860-a3b8hyyr	3385	14	method	method	NN
cord-006860-a3b8hyyr	3385	15	show	show	VBP
cord-006860-a3b8hyyr	3385	16	good	good	JJ
cord-006860-a3b8hyyr	3385	17	results	result	NNS
cord-006860-a3b8hyyr	3385	18	and	and	CC
cord-006860-a3b8hyyr	3385	19	the	the	DT
cord-006860-a3b8hyyr	3385	20	correlation	correlation	NN
cord-006860-a3b8hyyr	3385	21	between	between	IN
cord-006860-a3b8hyyr	3385	22	the	the	DT
cord-006860-a3b8hyyr	3385	23	CoaguChek	CoaguChek	NNP
cord-006860-a3b8hyyr	3385	24	®	®	POS
cord-006860-a3b8hyyr	3385	25	methods	method	NNS
cord-006860-a3b8hyyr	3385	26	is	be	VBZ
cord-006860-a3b8hyyr	3385	27	excellent	excellent	JJ
cord-006860-a3b8hyyr	3385	28	.	.	.
cord-006860-a3b8hyyr	3386	1	Mean	mean	JJ
cord-006860-a3b8hyyr	3386	2	differences	difference	NNS
cord-006860-a3b8hyyr	3386	3	to	to	IN
cord-006860-a3b8hyyr	3386	4	the	the	DT
cord-006860-a3b8hyyr	3386	5	lab	lab	NN
cord-006860-a3b8hyyr	3386	6	methods	method	NNS
cord-006860-a3b8hyyr	3386	7	are	be	VBP
cord-006860-a3b8hyyr	3386	8	-0.1	-0.1	:
cord-006860-a3b8hyyr	3386	9	INR	INR	NNP
cord-006860-a3b8hyyr	3386	10	in	in	IN
cord-006860-a3b8hyyr	3386	11	both	both	DT
cord-006860-a3b8hyyr	3386	12	cases	case	NNS
cord-006860-a3b8hyyr	3386	13	.	.	.
cord-006860-a3b8hyyr	3387	1	No	no	DT
cord-006860-a3b8hyyr	3387	2	mean	mean	JJ
cord-006860-a3b8hyyr	3387	3	deviation	deviation	NN
cord-006860-a3b8hyyr	3387	4	was	be	VBD
cord-006860-a3b8hyyr	3387	5	detectable	detectable	JJ
cord-006860-a3b8hyyr	3387	6	between	between	IN
cord-006860-a3b8hyyr	3387	7	the	the	DT
cord-006860-a3b8hyyr	3387	8	CoaguChek	CoaguChek	NNP
cord-006860-a3b8hyyr	3387	9	®	®	POS
cord-006860-a3b8hyyr	3387	10	methods	method	NNS
cord-006860-a3b8hyyr	3387	11	.	.	.
cord-006860-a3b8hyyr	3388	1	Scattering	scattering	NN
cord-006860-a3b8hyyr	3388	2	of	of	IN
cord-006860-a3b8hyyr	3388	3	CoaguChek	CoaguChek	NNP
cord-006860-a3b8hyyr	3388	4	®	®	,
cord-006860-a3b8hyyr	3388	5	versus	versus	IN
cord-006860-a3b8hyyr	3388	6	Hepato	Hepato	NNP
cord-006860-a3b8hyyr	3388	7	Quick	Quick	NNP
cord-006860-a3b8hyyr	3388	8	was	be	VBD
cord-006860-a3b8hyyr	3388	9	+	+	.
cord-006860-a3b8hyyr	3389	1	/-0.6	/-0.6	NFP
cord-006860-a3b8hyyr	3389	2	INR	INR	NNP
cord-006860-a3b8hyyr	3389	3	in	in	IN
cord-006860-a3b8hyyr	3389	4	the	the	DT
cord-006860-a3b8hyyr	3389	5	range	range	NN
cord-006860-a3b8hyyr	3389	6	1	1	CD
cord-006860-a3b8hyyr	3389	7	to	to	IN
cord-006860-a3b8hyyr	3389	8	4	4	CD
cord-006860-a3b8hyyr	3389	9	INR	INR	NNP
cord-006860-a3b8hyyr	3389	10	except	except	IN
cord-006860-a3b8hyyr	3389	11	for	for	IN
cord-006860-a3b8hyyr	3389	12	three	three	CD
cord-006860-a3b8hyyr	3389	13	outliers	outlier	NNS
cord-006860-a3b8hyyr	3389	14	and	and	CC
cord-006860-a3b8hyyr	3389	15	one	one	CD
cord-006860-a3b8hyyr	3389	16	patient	patient	NN
cord-006860-a3b8hyyr	3389	17	with	with	IN
cord-006860-a3b8hyyr	3389	18	fluctuating	fluctuate	VBG
cord-006860-a3b8hyyr	3389	19	results	result	NNS
cord-006860-a3b8hyyr	3389	20	in	in	IN
cord-006860-a3b8hyyr	3389	21	the	the	DT
cord-006860-a3b8hyyr	3389	22	lab	lab	NN
cord-006860-a3b8hyyr	3389	23	method	method	NN
cord-006860-a3b8hyyr	3389	24	which	which	WDT
cord-006860-a3b8hyyr	3389	25	could	could	MD
cord-006860-a3b8hyyr	3389	26	not	not	RB
cord-006860-a3b8hyyr	3389	27	be	be	VB
cord-006860-a3b8hyyr	3389	28	resolved	resolve	VBN
cord-006860-a3b8hyyr	3389	29	.	.	.
cord-006860-a3b8hyyr	3390	1	Introduction	introduction	NN
cord-006860-a3b8hyyr	3390	2	:	:	:
cord-006860-a3b8hyyr	3391	1	Haemorrhagic	Haemorrhagic	NNP
cord-006860-a3b8hyyr	3391	2	coumarin	coumarin	NN
cord-006860-a3b8hyyr	3391	3	skin	skin	NN
cord-006860-a3b8hyyr	3391	4	necrosis	necrosis	NN
cord-006860-a3b8hyyr	3391	5	is	be	VBZ
cord-006860-a3b8hyyr	3391	6	a	a	DT
cord-006860-a3b8hyyr	3391	7	severe	severe	JJ
cord-006860-a3b8hyyr	3391	8	complication	complication	NN
cord-006860-a3b8hyyr	3391	9	during	during	IN
cord-006860-a3b8hyyr	3391	10	initial	initial	JJ
cord-006860-a3b8hyyr	3391	11	phase	phase	NN
cord-006860-a3b8hyyr	3391	12	of	of	IN
cord-006860-a3b8hyyr	3391	13	oral	oral	JJ
cord-006860-a3b8hyyr	3391	14	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3391	15	therapy	therapy	NN
cord-006860-a3b8hyyr	3391	16	.	.	.
cord-006860-a3b8hyyr	3392	1	Histological	histological	JJ
cord-006860-a3b8hyyr	3392	2	examination	examination	NN
cord-006860-a3b8hyyr	3392	3	shows	show	VBZ
cord-006860-a3b8hyyr	3392	4	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	3392	5	occlusion	occlusion	NN
cord-006860-a3b8hyyr	3392	6	of	of	IN
cord-006860-a3b8hyyr	3392	7	small	small	JJ
cord-006860-a3b8hyyr	3392	8	vessels	vessel	NNS
cord-006860-a3b8hyyr	3392	9	,	,	,
cord-006860-a3b8hyyr	3392	10	but	but	CC
cord-006860-a3b8hyyr	3392	11	little	little	JJ
cord-006860-a3b8hyyr	3392	12	is	be	VBZ
cord-006860-a3b8hyyr	3392	13	known	know	VBN
cord-006860-a3b8hyyr	3392	14	concerning	concern	VBG
cord-006860-a3b8hyyr	3392	15	the	the	DT
cord-006860-a3b8hyyr	3392	16	pathophysiologic	pathophysiologic	JJ
cord-006860-a3b8hyyr	3392	17	background	background	NN
cord-006860-a3b8hyyr	3392	18	of	of	IN
cord-006860-a3b8hyyr	3392	19	the	the	DT
cord-006860-a3b8hyyr	3392	20	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3392	21	component	component	NN
cord-006860-a3b8hyyr	3392	22	.	.	.
cord-006860-a3b8hyyr	3393	1	Recently	recently	RB
cord-006860-a3b8hyyr	3393	2	,	,	,
cord-006860-a3b8hyyr	3393	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	3393	4	described	describe	VBD
cord-006860-a3b8hyyr	3393	5	protein	protein	NN
cord-006860-a3b8hyyr	3393	6	Z	Z	NNP
cord-006860-a3b8hyyr	3393	7	deficiency	deficiency	NN
cord-006860-a3b8hyyr	3393	8	in	in	IN
cord-006860-a3b8hyyr	3393	9	patients	patient	NNS
cord-006860-a3b8hyyr	3393	10	with	with	IN
cord-006860-a3b8hyyr	3393	11	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3393	12	complications	complication	NNS
cord-006860-a3b8hyyr	3393	13	of	of	IN
cord-006860-a3b8hyyr	3393	14	otherwise	otherwise	RB
cord-006860-a3b8hyyr	3393	15	unknown	unknown	JJ
cord-006860-a3b8hyyr	3393	16	origin	origin	NN
cord-006860-a3b8hyyr	3393	17	.	.	.
cord-006860-a3b8hyyr	3394	1	Thus	thus	RB
cord-006860-a3b8hyyr	3394	2	,	,	,
cord-006860-a3b8hyyr	3394	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	3394	4	were	be	VBD
cord-006860-a3b8hyyr	3394	5	prompted	prompt	VBN
cord-006860-a3b8hyyr	3394	6	to	to	TO
cord-006860-a3b8hyyr	3394	7	measure	measure	VB
cord-006860-a3b8hyyr	3394	8	protein	protein	NN
cord-006860-a3b8hyyr	3394	9	Z	z	NN
cord-006860-a3b8hyyr	3394	10	in	in	IN
cord-006860-a3b8hyyr	3394	11	patients	patient	NNS
cord-006860-a3b8hyyr	3394	12	with	with	IN
cord-006860-a3b8hyyr	3394	13	coumarin	coumarin	NN
cord-006860-a3b8hyyr	3394	14	skin	skin	NN
cord-006860-a3b8hyyr	3394	15	necrosis	necrosis	NN
cord-006860-a3b8hyyr	3394	16	.	.	.
cord-006860-a3b8hyyr	3395	1	Patients	patient	NNS
cord-006860-a3b8hyyr	3395	2	:	:	:
cord-006860-a3b8hyyr	3395	3	4	4	CD
cord-006860-a3b8hyyr	3395	4	patients	patient	NNS
cord-006860-a3b8hyyr	3395	5	(	(	-LRB-
cord-006860-a3b8hyyr	3395	6	I	-PRON-	PRP
cord-006860-a3b8hyyr	3395	7	man	man	VBP
cord-006860-a3b8hyyr	3395	8	,	,	,
cord-006860-a3b8hyyr	3395	9	4	4	CD
cord-006860-a3b8hyyr	3395	10	women	woman	NNS
cord-006860-a3b8hyyr	3395	11	;	;	:
cord-006860-a3b8hyyr	3395	12	age	age	NN
cord-006860-a3b8hyyr	3395	13	:	:	:
cord-006860-a3b8hyyr	3395	14	35±10	35±10	NN
cord-006860-a3b8hyyr	3395	15	years	year	NNS
cord-006860-a3b8hyyr	3395	16	)	)	-RRB-
cord-006860-a3b8hyyr	3395	17	suffering	suffer	VBG
cord-006860-a3b8hyyr	3395	18	from	from	IN
cord-006860-a3b8hyyr	3395	19	haemorrhagic	haemorrhagic	JJ
cord-006860-a3b8hyyr	3395	20	coumarin	coumarin	NN
cord-006860-a3b8hyyr	3395	21	skin	skin	NN
cord-006860-a3b8hyyr	3395	22	necrosis	necrosis	NN
cord-006860-a3b8hyyr	3395	23	were	be	VBD
cord-006860-a3b8hyyr	3395	24	examined	examine	VBN
cord-006860-a3b8hyyr	3395	25	.	.	.
cord-006860-a3b8hyyr	3396	1	All	all	DT
cord-006860-a3b8hyyr	3396	2	patients	patient	NNS
cord-006860-a3b8hyyr	3396	3	had	have	VBD
cord-006860-a3b8hyyr	3396	4	normal	normal	JJ
cord-006860-a3b8hyyr	3396	5	liver	liver	NN
cord-006860-a3b8hyyr	3396	6	protein	protein	NN
cord-006860-a3b8hyyr	3396	7	synthesis	synthesis	NN
cord-006860-a3b8hyyr	3396	8	function	function	NN
cord-006860-a3b8hyyr	3396	9	,	,	,
cord-006860-a3b8hyyr	3396	10	none	none	NN
cord-006860-a3b8hyyr	3396	11	was	be	VBD
cord-006860-a3b8hyyr	3396	12	under	under	IN
cord-006860-a3b8hyyr	3396	13	oral	oral	JJ
cord-006860-a3b8hyyr	3396	14	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3396	15	treatment	treatment	NN
cord-006860-a3b8hyyr	3396	16	during	during	IN
cord-006860-a3b8hyyr	3396	17	this	this	DT
cord-006860-a3b8hyyr	3396	18	study	study	NN
cord-006860-a3b8hyyr	3396	19	.	.	.
cord-006860-a3b8hyyr	3397	1	Method	method	NN
cord-006860-a3b8hyyr	3397	2	:	:	:
cord-006860-a3b8hyyr	3397	3	Protein	protein	NN
cord-006860-a3b8hyyr	3397	4	Z	z	NN
cord-006860-a3b8hyyr	3397	5	antigen	antigen	NN
cord-006860-a3b8hyyr	3397	6	test	test	NN
cord-006860-a3b8hyyr	3397	7	,	,	,
cord-006860-a3b8hyyr	3397	8	Diagnostika	Diagnostika	NNP
cord-006860-a3b8hyyr	3397	9	Stago	Stago	NNP
cord-006860-a3b8hyyr	3397	10	,	,	,
cord-006860-a3b8hyyr	3397	11	France	France	NNP
cord-006860-a3b8hyyr	3397	12	.	.	.
cord-006860-a3b8hyyr	3398	1	Results	result	NNS
cord-006860-a3b8hyyr	3398	2	:	:	:
cord-006860-a3b8hyyr	3399	1	4	4	CD
cord-006860-a3b8hyyr	3399	2	out	out	IN
cord-006860-a3b8hyyr	3399	3	of	of	IN
cord-006860-a3b8hyyr	3399	4	the	the	DT
cord-006860-a3b8hyyr	3399	5	5	5	CD
cord-006860-a3b8hyyr	3399	6	patients	patient	NNS
cord-006860-a3b8hyyr	3399	7	examined	examine	VBN
cord-006860-a3b8hyyr	3399	8	had	have	VBD
cord-006860-a3b8hyyr	3399	9	diminished	diminish	VBN
cord-006860-a3b8hyyr	3399	10	protein	protein	NN
cord-006860-a3b8hyyr	3399	11	Z	z	NN
cord-006860-a3b8hyyr	3399	12	levels	level	NNS
cord-006860-a3b8hyyr	3399	13	(	(	-LRB-
cord-006860-a3b8hyyr	3399	14	700	700	CD
cord-006860-a3b8hyyr	3399	15	,	,	,
cord-006860-a3b8hyyr	3399	16	820	820	CD
cord-006860-a3b8hyyr	3399	17	,	,	,
cord-006860-a3b8hyyr	3399	18	1080	1080	CD
cord-006860-a3b8hyyr	3399	19	,	,	,
cord-006860-a3b8hyyr	3399	20	1700	1700	CD
cord-006860-a3b8hyyr	3399	21	ug	ug	NNP
cord-006860-a3b8hyyr	3399	22	/	/	SYM
cord-006860-a3b8hyyr	3399	23	l	l	NNP
cord-006860-a3b8hyyr	3399	24	)	)	-RRB-
cord-006860-a3b8hyyr	3399	25	in	in	IN
cord-006860-a3b8hyyr	3399	26	comparison	comparison	NN
cord-006860-a3b8hyyr	3399	27	to	to	IN
cord-006860-a3b8hyyr	3399	28	normals	normal	NNS
cord-006860-a3b8hyyr	3399	29	(	(	-LRB-
cord-006860-a3b8hyyr	3399	30	2900	2900	CD
cord-006860-a3b8hyyr	3399	31	ug	ug	NNP
cord-006860-a3b8hyyr	3399	32	/	/	SYM
cord-006860-a3b8hyyr	3399	33	l	l	NNP
cord-006860-a3b8hyyr	3399	34	)	)	-RRB-
cord-006860-a3b8hyyr	3399	35	.	.	.
cord-006860-a3b8hyyr	3400	1	In	in	IN
cord-006860-a3b8hyyr	3400	2	one	one	CD
cord-006860-a3b8hyyr	3400	3	of	of	IN
cord-006860-a3b8hyyr	3400	4	our	-PRON-	PRP$
cord-006860-a3b8hyyr	3400	5	patients	patient	NNS
cord-006860-a3b8hyyr	3400	6	,	,	,
cord-006860-a3b8hyyr	3400	7	protein	protein	NN
cord-006860-a3b8hyyr	3400	8	Z	Z	NNP
cord-006860-a3b8hyyr	3400	9	was	be	VBD
cord-006860-a3b8hyyr	3400	10	normal	normal	JJ
cord-006860-a3b8hyyr	3400	11	(	(	-LRB-
cord-006860-a3b8hyyr	3400	12	3020	3020	CD
cord-006860-a3b8hyyr	3400	13	ug	ug	NNP
cord-006860-a3b8hyyr	3400	14	/	/	SYM
cord-006860-a3b8hyyr	3400	15	l	l	NNP
cord-006860-a3b8hyyr	3400	16	)	)	-RRB-
cord-006860-a3b8hyyr	3400	17	.	.	.
cord-006860-a3b8hyyr	3401	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	3401	2	:	:	:
cord-006860-a3b8hyyr	3402	1	Low	low	JJ
cord-006860-a3b8hyyr	3402	2	protein	protein	NN
cord-006860-a3b8hyyr	3402	3	Z	z	NN
cord-006860-a3b8hyyr	3402	4	levels	level	NNS
cord-006860-a3b8hyyr	3402	5	are	be	VBP
cord-006860-a3b8hyyr	3402	6	additional	additional	JJ
cord-006860-a3b8hyyr	3402	7	risk	risk	NN
cord-006860-a3b8hyyr	3402	8	factors	factor	NNS
cord-006860-a3b8hyyr	3402	9	for	for	IN
cord-006860-a3b8hyyr	3402	10	haemorrhagic	haemorrhagic	JJ
cord-006860-a3b8hyyr	3402	11	coumarin	coumarin	NN
cord-006860-a3b8hyyr	3402	12	skin	skin	NN
cord-006860-a3b8hyyr	3402	13	necrosis	necrosis	NN
cord-006860-a3b8hyyr	3402	14	.	.	.
cord-006860-a3b8hyyr	3403	1	Oral	oral	JJ
cord-006860-a3b8hyyr	3403	2	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3403	3	therapy	therapy	NN
cord-006860-a3b8hyyr	3403	4	is	be	VBZ
cord-006860-a3b8hyyr	3403	5	the	the	DT
cord-006860-a3b8hyyr	3403	6	treatment	treatment	NN
cord-006860-a3b8hyyr	3403	7	of	of	IN
cord-006860-a3b8hyyr	3403	8	choice	choice	NN
cord-006860-a3b8hyyr	3403	9	in	in	IN
cord-006860-a3b8hyyr	3403	10	patients	patient	NNS
cord-006860-a3b8hyyr	3403	11	with	with	IN
cord-006860-a3b8hyyr	3403	12	need	need	NN
cord-006860-a3b8hyyr	3403	13	for	for	IN
cord-006860-a3b8hyyr	3403	14	long	long	JJ
cord-006860-a3b8hyyr	3403	15	-	-	HYPH
cord-006860-a3b8hyyr	3403	16	term	term	NN
cord-006860-a3b8hyyr	3403	17	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3403	18	.	.	.
cord-006860-a3b8hyyr	3404	1	Since	since	IN
cord-006860-a3b8hyyr	3404	2	oral	oral	JJ
cord-006860-a3b8hyyr	3404	3	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	3404	4	interfere	interfere	VBP
cord-006860-a3b8hyyr	3404	5	with	with	IN
cord-006860-a3b8hyyr	3404	6	the	the	DT
cord-006860-a3b8hyyr	3404	7	function	function	NN
cord-006860-a3b8hyyr	3404	8	of	of	IN
cord-006860-a3b8hyyr	3404	9	vitamin	vitamin	NN
cord-006860-a3b8hyyr	3404	10	K	k	NN
cord-006860-a3b8hyyr	3404	11	,	,	,
cord-006860-a3b8hyyr	3404	12	it	-PRON-	PRP
cord-006860-a3b8hyyr	3404	13	is	be	VBZ
cord-006860-a3b8hyyr	3404	14	not	not	RB
cord-006860-a3b8hyyr	3404	15	clear	clear	JJ
cord-006860-a3b8hyyr	3404	16	whether	whether	IN
cord-006860-a3b8hyyr	3404	17	stable	stable	JJ
cord-006860-a3b8hyyr	3404	18	oral	oral	JJ
cord-006860-a3b8hyyr	3404	19	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3404	20	can	can	MD
cord-006860-a3b8hyyr	3404	21	be	be	VB
cord-006860-a3b8hyyr	3404	22	achieved	achieve	VBN
cord-006860-a3b8hyyr	3404	23	in	in	IN
cord-006860-a3b8hyyr	3404	24	patients	patient	NNS
cord-006860-a3b8hyyr	3404	25	with	with	IN
cord-006860-a3b8hyyr	3404	26	need	need	NN
cord-006860-a3b8hyyr	3404	27	for	for	IN
cord-006860-a3b8hyyr	3404	28	continous	continous	JJ
cord-006860-a3b8hyyr	3404	29	substitution	substitution	NN
cord-006860-a3b8hyyr	3404	30	of	of	IN
cord-006860-a3b8hyyr	3404	31	fat	fat	JJ
cord-006860-a3b8hyyr	3404	32	-	-	HYPH
cord-006860-a3b8hyyr	3404	33	soluble	soluble	JJ
cord-006860-a3b8hyyr	3404	34	vitamins	vitamin	NNS
cord-006860-a3b8hyyr	3404	35	including	include	VBG
cord-006860-a3b8hyyr	3404	36	vitamin	vitamin	NN
cord-006860-a3b8hyyr	3405	1	K.	K.	NNP
cord-006860-a3b8hyyr	3405	2	We	-PRON-	PRP
cord-006860-a3b8hyyr	3405	3	report	report	VBP
cord-006860-a3b8hyyr	3405	4	about	about	IN
cord-006860-a3b8hyyr	3405	5	a	a	DT
cord-006860-a3b8hyyr	3405	6	59-year	59-year	JJ
cord-006860-a3b8hyyr	3405	7	-	-	HYPH
cord-006860-a3b8hyyr	3405	8	old	old	JJ
cord-006860-a3b8hyyr	3405	9	man	man	NN
cord-006860-a3b8hyyr	3405	10	who	who	WP
cord-006860-a3b8hyyr	3405	11	had	have	VBD
cord-006860-a3b8hyyr	3405	12	experienced	experience	VBN
cord-006860-a3b8hyyr	3405	13	progressive	progressive	JJ
cord-006860-a3b8hyyr	3405	14	hypertrophic	hypertrophic	JJ
cord-006860-a3b8hyyr	3405	15	obstructive	obstructive	JJ
cord-006860-a3b8hyyr	3405	16	cardiomyopathy	cardiomyopathy	NN
cord-006860-a3b8hyyr	3405	17	over	over	IN
cord-006860-a3b8hyyr	3405	18	the	the	DT
cord-006860-a3b8hyyr	3405	19	preceeding	preceede	VBG
cord-006860-a3b8hyyr	3405	20	21	21	CD
cord-006860-a3b8hyyr	3405	21	years	year	NNS
cord-006860-a3b8hyyr	3405	22	.	.	.
cord-006860-a3b8hyyr	3406	1	Atrial	atrial	JJ
cord-006860-a3b8hyyr	3406	2	fibrillation	fibrillation	NN
cord-006860-a3b8hyyr	3406	3	has	have	VBZ
cord-006860-a3b8hyyr	3406	4	been	be	VBN
cord-006860-a3b8hyyr	3406	5	first	first	RB
cord-006860-a3b8hyyr	3406	6	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	3406	7	18	18	CD
cord-006860-a3b8hyyr	3406	8	years	year	NNS
cord-006860-a3b8hyyr	3406	9	ago	ago	RB
cord-006860-a3b8hyyr	3406	10	.	.	.
cord-006860-a3b8hyyr	3407	1	Latter	latter	RB
cord-006860-a3b8hyyr	3407	2	on	on	RB
cord-006860-a3b8hyyr	3407	3	,	,	,
cord-006860-a3b8hyyr	3407	4	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	3407	5	ischemic	ischemic	JJ
cord-006860-a3b8hyyr	3407	6	attacks	attack	NNS
cord-006860-a3b8hyyr	3407	7	and	and	CC
cord-006860-a3b8hyyr	3407	8	embolism	embolism	NN
cord-006860-a3b8hyyr	3407	9	of	of	IN
cord-006860-a3b8hyyr	3407	10	the	the	DT
cord-006860-a3b8hyyr	3407	11	right	right	NN
cord-006860-a3b8hyyr	3408	1	arteria	arteria	NNP
cord-006860-a3b8hyyr	3408	2	iliaca	iliaca	NNP
cord-006860-a3b8hyyr	3408	3	occurred	occur	VBD
cord-006860-a3b8hyyr	3408	4	.	.	.
cord-006860-a3b8hyyr	3409	1	In	in	IN
cord-006860-a3b8hyyr	3409	2	1993	1993	CD
cord-006860-a3b8hyyr	3409	3	the	the	DT
cord-006860-a3b8hyyr	3409	4	patient	patient	NN
cord-006860-a3b8hyyr	3409	5	received	receive	VBD
cord-006860-a3b8hyyr	3409	6	extirpation	extirpation	NN
cord-006860-a3b8hyyr	3409	7	of	of	IN
cord-006860-a3b8hyyr	3409	8	the	the	DT
cord-006860-a3b8hyyr	3409	9	ileum	ileum	NN
cord-006860-a3b8hyyr	3409	10	and	and	CC
cord-006860-a3b8hyyr	3409	11	subtotal	subtotal	NN
cord-006860-a3b8hyyr	3409	12	amputation	amputation	NN
cord-006860-a3b8hyyr	3409	13	of	of	IN
cord-006860-a3b8hyyr	3409	14	the	the	DT
cord-006860-a3b8hyyr	3409	15	jejunum	jejunum	NNS
cord-006860-a3b8hyyr	3409	16	because	because	IN
cord-006860-a3b8hyyr	3409	17	of	of	IN
cord-006860-a3b8hyyr	3409	18	mesenteric	mesenteric	JJ
cord-006860-a3b8hyyr	3409	19	infarction	infarction	NN
cord-006860-a3b8hyyr	3409	20	.	.	.
cord-006860-a3b8hyyr	3410	1	The	the	DT
cord-006860-a3b8hyyr	3410	2	resulting	result	VBG
cord-006860-a3b8hyyr	3410	3	short	short	JJ
cord-006860-a3b8hyyr	3410	4	bowel	bowel	NN
cord-006860-a3b8hyyr	3410	5	syndrome	syndrome	NN
cord-006860-a3b8hyyr	3410	6	requires	require	VBZ
cord-006860-a3b8hyyr	3410	7	continous	continous	JJ
cord-006860-a3b8hyyr	3410	8	substitution	substitution	NN
cord-006860-a3b8hyyr	3410	9	of	of	IN
cord-006860-a3b8hyyr	3410	10	fat	fat	JJ
cord-006860-a3b8hyyr	3410	11	-	-	HYPH
cord-006860-a3b8hyyr	3410	12	soluble	soluble	JJ
cord-006860-a3b8hyyr	3410	13	vitamins	vitamin	NNS
cord-006860-a3b8hyyr	3410	14	.	.	.
cord-006860-a3b8hyyr	3411	1	Since	since	IN
cord-006860-a3b8hyyr	3411	2	vitamin	vitamin	NN
cord-006860-a3b8hyyr	3411	3	K	k	NN
cord-006860-a3b8hyyr	3411	4	free	free	JJ
cord-006860-a3b8hyyr	3411	5	preparations	preparation	NNS
cord-006860-a3b8hyyr	3411	6	of	of	IN
cord-006860-a3b8hyyr	3411	7	fat	fat	JJ
cord-006860-a3b8hyyr	3411	8	-	-	HYPH
cord-006860-a3b8hyyr	3411	9	soluble	soluble	JJ
cord-006860-a3b8hyyr	3411	10	vitamins	vitamin	NNS
cord-006860-a3b8hyyr	3411	11	for	for	IN
cord-006860-a3b8hyyr	3411	12	parenteral	parenteral	JJ
cord-006860-a3b8hyyr	3411	13	use	use	NN
cord-006860-a3b8hyyr	3411	14	are	be	VBP
cord-006860-a3b8hyyr	3411	15	not	not	RB
cord-006860-a3b8hyyr	3411	16	available	available	JJ
cord-006860-a3b8hyyr	3411	17	,	,	,
cord-006860-a3b8hyyr	3411	18	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	3411	19	of	of	IN
cord-006860-a3b8hyyr	3411	20	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3411	21	has	have	VBZ
cord-006860-a3b8hyyr	3411	22	been	be	VBN
cord-006860-a3b8hyyr	3411	23	performed	perform	VBN
cord-006860-a3b8hyyr	3411	24	with	with	IN
cord-006860-a3b8hyyr	3411	25	unfractionated	unfractionated	JJ
cord-006860-a3b8hyyr	3411	26	hepadn	hepadn	NNP
cord-006860-a3b8hyyr	3411	27	.	.	.
cord-006860-a3b8hyyr	3412	1	As	as	IN
cord-006860-a3b8hyyr	3412	2	a	a	DT
cord-006860-a3b8hyyr	3412	3	consequence	consequence	NN
cord-006860-a3b8hyyr	3412	4	of	of	IN
cord-006860-a3b8hyyr	3412	5	the	the	DT
cord-006860-a3b8hyyr	3412	6	longterm	longterm	JJ
cord-006860-a3b8hyyr	3412	7	treatment	treatment	NN
cord-006860-a3b8hyyr	3412	8	with	with	IN
cord-006860-a3b8hyyr	3412	9	hepadn	hepadn	NNP
cord-006860-a3b8hyyr	3412	10	the	the	DT
cord-006860-a3b8hyyr	3412	11	patient	patient	NN
cord-006860-a3b8hyyr	3412	12	developed	develop	VBD
cord-006860-a3b8hyyr	3412	13	severe	severe	JJ
cord-006860-a3b8hyyr	3412	14	osteoporosis	osteoporosis	NN
cord-006860-a3b8hyyr	3412	15	.	.	.
cord-006860-a3b8hyyr	3413	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	3413	2	,	,	,
cord-006860-a3b8hyyr	3413	3	the	the	DT
cord-006860-a3b8hyyr	3413	4	decission	decission	NN
cord-006860-a3b8hyyr	3413	5	1	1	CD
cord-006860-a3b8hyyr	3413	6	:	:	:
cord-006860-a3b8hyyr	3413	7	o	o	NNP
cord-006860-a3b8hyyr	3413	8	discontinuate	discontinuate	NNP
cord-006860-a3b8hyyr	3413	9	heparin	heparin	NNP
cord-006860-a3b8hyyr	3413	10	therapy	therapy	NN
cord-006860-a3b8hyyr	3413	11	and	and	CC
cord-006860-a3b8hyyr	3413	12	initiate	initiate	VB
cord-006860-a3b8hyyr	3413	13	oral	oral	JJ
cord-006860-a3b8hyyr	3413	14	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3413	15	has	have	VBZ
cord-006860-a3b8hyyr	3413	16	been	be	VBN
cord-006860-a3b8hyyr	3413	17	made	make	VBN
cord-006860-a3b8hyyr	3413	18	.	.	.
cord-006860-a3b8hyyr	3414	1	Because	because	IN
cord-006860-a3b8hyyr	3414	2	of	of	IN
cord-006860-a3b8hyyr	3414	3	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3414	4	shorter	short	JJR
cord-006860-a3b8hyyr	3414	5	halflife	halflife	NN
cord-006860-a3b8hyyr	3414	6	warfarin	warfarin	NNP
cord-006860-a3b8hyyr	3414	7	(	(	-LRB-
cord-006860-a3b8hyyr	3414	8	coumadin	coumadin	NNP
cord-006860-a3b8hyyr	3414	9	)	)	-RRB-
cord-006860-a3b8hyyr	3414	10	was	be	VBD
cord-006860-a3b8hyyr	3414	11	used	use	VBN
cord-006860-a3b8hyyr	3414	12	instead	instead	RB
cord-006860-a3b8hyyr	3414	13	of	of	IN
cord-006860-a3b8hyyr	3414	14	dicoumarol	dicoumarol	NNP
cord-006860-a3b8hyyr	3414	15	.	.	.
cord-006860-a3b8hyyr	3415	1	Over	over	IN
cord-006860-a3b8hyyr	3415	2	a	a	DT
cord-006860-a3b8hyyr	3415	3	4	4	CD
cord-006860-a3b8hyyr	3415	4	weeks	week	NNS
cord-006860-a3b8hyyr	3415	5	lasting	last	VBG
cord-006860-a3b8hyyr	3415	6	induction	induction	NN
cord-006860-a3b8hyyr	3415	7	phase	phase	NN
cord-006860-a3b8hyyr	3415	8	INR	INR	NNP
cord-006860-a3b8hyyr	3415	9	values	value	NNS
cord-006860-a3b8hyyr	3415	10	were	be	VBD
cord-006860-a3b8hyyr	3415	11	controlled	control	VBN
cord-006860-a3b8hyyr	3415	12	daily	daily	RB
cord-006860-a3b8hyyr	3415	13	.	.	.
cord-006860-a3b8hyyr	3416	1	A	a	DT
cord-006860-a3b8hyyr	3416	2	dosage	dosage	NN
cord-006860-a3b8hyyr	3416	3	regime	regime	NN
cord-006860-a3b8hyyr	3416	4	starting	start	VBG
cord-006860-a3b8hyyr	3416	5	with	with	IN
cord-006860-a3b8hyyr	3416	6	'	'	CD
cord-006860-a3b8hyyr	3416	7	10	10	CD
cord-006860-a3b8hyyr	3416	8	mg	mg	NNS
cord-006860-a3b8hyyr	3416	9	warfarin	warfarin	RB
cord-006860-a3b8hyyr	3416	10	at	at	IN
cord-006860-a3b8hyyr	3416	11	the	the	DT
cord-006860-a3b8hyyr	3416	12	day	day	NN
cord-006860-a3b8hyyr	3416	13	of	of	IN
cord-006860-a3b8hyyr	3416	14	vitamin	vitamin	NN
cord-006860-a3b8hyyr	3416	15	application	application	NN
cord-006860-a3b8hyyr	3416	16	(	(	-LRB-
cord-006860-a3b8hyyr	3416	17	day	day	NN
cord-006860-a3b8hyyr	3416	18	1	1	CD
cord-006860-a3b8hyyr	3416	19	)	)	-RRB-
cord-006860-a3b8hyyr	3416	20	followed	follow	VBN
cord-006860-a3b8hyyr	3416	21	by	by	IN
cord-006860-a3b8hyyr	3416	22	3.75	3.75	CD
cord-006860-a3b8hyyr	3416	23	mg	mg	NN
cord-006860-a3b8hyyr	3416	24	on	on	IN
cord-006860-a3b8hyyr	3416	25	day	day	NN
cord-006860-a3b8hyyr	3416	26	2	2	CD
cord-006860-a3b8hyyr	3416	27	and	and	CC
cord-006860-a3b8hyyr	3416	28	1.25	1.25	CD
cord-006860-a3b8hyyr	3416	29	mg	mg	NNS
cord-006860-a3b8hyyr	3416	30	on	on	IN
cord-006860-a3b8hyyr	3416	31	days	day	NNS
cord-006860-a3b8hyyr	3416	32	3	3	CD
cord-006860-a3b8hyyr	3416	33	,	,	,
cord-006860-a3b8hyyr	3416	34	5	5	CD
cord-006860-a3b8hyyr	3416	35	,	,	,
cord-006860-a3b8hyyr	3416	36	and	and	CC
cord-006860-a3b8hyyr	3416	37	6	6	CD
cord-006860-a3b8hyyr	3416	38	,	,	,
cord-006860-a3b8hyyr	3416	39	respectively	respectively	RB
cord-006860-a3b8hyyr	3416	40	,	,	,
cord-006860-a3b8hyyr	3416	41	was	be	VBD
cord-006860-a3b8hyyr	3416	42	found	find	VBN
cord-006860-a3b8hyyr	3416	43	to	to	TO
cord-006860-a3b8hyyr	3416	44	be	be	VB
cord-006860-a3b8hyyr	3416	45	optimal	optimal	JJ
cord-006860-a3b8hyyr	3416	46	to	to	TO
cord-006860-a3b8hyyr	3416	47	maintain	maintain	VB
cord-006860-a3b8hyyr	3416	48	INR	INR	NNP
cord-006860-a3b8hyyr	3416	49	values	value	NNS
cord-006860-a3b8hyyr	3416	50	within	within	IN
cord-006860-a3b8hyyr	3416	51	the	the	DT
cord-006860-a3b8hyyr	3416	52	target	target	NN
cord-006860-a3b8hyyr	3416	53	range	range	NN
cord-006860-a3b8hyyr	3416	54	(	(	-LRB-
cord-006860-a3b8hyyr	3416	55	INR	INR	NNP
cord-006860-a3b8hyyr	3416	56	:	:	:
cord-006860-a3b8hyyr	3416	57	2.0	2.0	CD
cord-006860-a3b8hyyr	3416	58	-	-	HYPH
cord-006860-a3b8hyyr	3416	59	3.0	3.0	CD
cord-006860-a3b8hyyr	3416	60	)	)	-RRB-
cord-006860-a3b8hyyr	3416	61	.	.	.
cord-006860-a3b8hyyr	3417	1	In	in	IN
cord-006860-a3b8hyyr	3417	2	order	order	NN
cord-006860-a3b8hyyr	3417	3	to	to	TO
cord-006860-a3b8hyyr	3417	4	minimize	minimize	VB
cord-006860-a3b8hyyr	3417	5	the	the	DT
cord-006860-a3b8hyyr	3417	6	risk	risk	NN
cord-006860-a3b8hyyr	3417	7	of	of	IN
cord-006860-a3b8hyyr	3417	8	hemorrhage	hemorrhage	NN
cord-006860-a3b8hyyr	3417	9	the	the	DT
cord-006860-a3b8hyyr	3417	10	vitamin	vitamin	NN
cord-006860-a3b8hyyr	3417	11	administration	administration	NN
cord-006860-a3b8hyyr	3417	12	was	be	VBD
cord-006860-a3b8hyyr	3417	13	changed	change	VBN
cord-006860-a3b8hyyr	3417	14	to	to	IN
cord-006860-a3b8hyyr	3417	15	the	the	DT
cord-006860-a3b8hyyr	3417	16	subcutaneous	subcutaneous	JJ
cord-006860-a3b8hyyr	3417	17	route	route	NN
cord-006860-a3b8hyyr	3417	18	.	.	.
cord-006860-a3b8hyyr	3418	1	During	during	IN
cord-006860-a3b8hyyr	3418	2	an	an	DT
cord-006860-a3b8hyyr	3418	3	observation	observation	NN
cord-006860-a3b8hyyr	3418	4	period	period	NN
cord-006860-a3b8hyyr	3418	5	of	of	IN
cord-006860-a3b8hyyr	3418	6	6	6	CD
cord-006860-a3b8hyyr	3418	7	months	month	NNS
cord-006860-a3b8hyyr	3418	8	neither	neither	CC
cord-006860-a3b8hyyr	3418	9	any	any	DT
cord-006860-a3b8hyyr	3418	10	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	3418	11	or	or	CC
cord-006860-a3b8hyyr	3418	12	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	3418	13	complications	complication	NNS
cord-006860-a3b8hyyr	3418	14	nor	nor	CC
cord-006860-a3b8hyyr	3418	15	a	a	DT
cord-006860-a3b8hyyr	3418	16	vitamin	vitamin	NN
cord-006860-a3b8hyyr	3418	17	deficiency	deficiency	NN
cord-006860-a3b8hyyr	3418	18	occurred	occur	VBD
cord-006860-a3b8hyyr	3418	19	.	.	.
cord-006860-a3b8hyyr	3419	1	These	these	DT
cord-006860-a3b8hyyr	3419	2	data	datum	NNS
cord-006860-a3b8hyyr	3419	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	3419	4	that	that	IN
cord-006860-a3b8hyyr	3419	5	stable	stable	JJ
cord-006860-a3b8hyyr	3419	6	oral	oral	JJ
cord-006860-a3b8hyyr	3419	7	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3419	8	can	can	MD
cord-006860-a3b8hyyr	3419	9	be	be	VB
cord-006860-a3b8hyyr	3419	10	achieved	achieve	VBN
cord-006860-a3b8hyyr	3419	11	despite	despite	IN
cord-006860-a3b8hyyr	3419	12	extreme	extreme	JJ
cord-006860-a3b8hyyr	3419	13	variation	variation	NN
cord-006860-a3b8hyyr	3419	14	of	of	IN
cord-006860-a3b8hyyr	3419	15	vitamin	vitamin	NN
cord-006860-a3b8hyyr	3419	16	K	k	NN
cord-006860-a3b8hyyr	3419	17	plasma	plasma	NN
cord-006860-a3b8hyyr	3419	18	levels	level	NNS
cord-006860-a3b8hyyr	3419	19	.	.	.
cord-006860-a3b8hyyr	3420	1	Portable	portable	JJ
cord-006860-a3b8hyyr	3420	2	monitors	monitor	NNS
cord-006860-a3b8hyyr	3420	3	for	for	IN
cord-006860-a3b8hyyr	3420	4	home	home	NN
cord-006860-a3b8hyyr	3420	5	monitoring	monitoring	NN
cord-006860-a3b8hyyr	3420	6	of	of	IN
cord-006860-a3b8hyyr	3420	7	INR	INR	NNP
cord-006860-a3b8hyyr	3420	8	are	be	VBP
cord-006860-a3b8hyyr	3420	9	well	well	RB
cord-006860-a3b8hyyr	3420	10	established	establish	VBN
cord-006860-a3b8hyyr	3420	11	for	for	IN
cord-006860-a3b8hyyr	3420	12	adults	adult	NNS
cord-006860-a3b8hyyr	3420	13	on	on	IN
cord-006860-a3b8hyyr	3420	14	oral	oral	JJ
cord-006860-a3b8hyyr	3420	15	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	3420	16	.	.	.
cord-006860-a3b8hyyr	3421	1	Patient	Patient	NNP
cord-006860-a3b8hyyr	3421	2	's	's	POS
cord-006860-a3b8hyyr	3421	3	compliance	compliance	NN
cord-006860-a3b8hyyr	3421	4	is	be	VBZ
cord-006860-a3b8hyyr	3421	5	improved	improve	VBN
cord-006860-a3b8hyyr	3421	6	as	as	RB
cord-006860-a3b8hyyr	3421	7	well	well	RB
cord-006860-a3b8hyyr	3421	8	as	as	IN
cord-006860-a3b8hyyr	3421	9	long	long	JJ
cord-006860-a3b8hyyr	3421	10	term	term	NN
cord-006860-a3b8hyyr	3421	11	outcome	outcome	NN
cord-006860-a3b8hyyr	3421	12	.	.	.
cord-006860-a3b8hyyr	3422	1	Experience	experience	NN
cord-006860-a3b8hyyr	3422	2	concerning	concern	VBG
cord-006860-a3b8hyyr	3422	3	accuracy	accuracy	NN
cord-006860-a3b8hyyr	3422	4	of	of	IN
cord-006860-a3b8hyyr	3422	5	the	the	DT
cord-006860-a3b8hyyr	3422	6	procedure	procedure	NN
cord-006860-a3b8hyyr	3422	7	in	in	IN
cord-006860-a3b8hyyr	3422	8	children	child	NNS
cord-006860-a3b8hyyr	3422	9	is	be	VBZ
cord-006860-a3b8hyyr	3422	10	limited	limit	VBN
cord-006860-a3b8hyyr	3422	11	.	.	.
cord-006860-a3b8hyyr	3423	1	32	32	CD
cord-006860-a3b8hyyr	3423	2	INR	INR	NNP
cord-006860-a3b8hyyr	3423	3	determinations	determination	NNS
cord-006860-a3b8hyyr	3423	4	were	be	VBD
cord-006860-a3b8hyyr	3423	5	performed	perform	VBN
cord-006860-a3b8hyyr	3423	6	in	in	IN
cord-006860-a3b8hyyr	3423	7	parallel	parallel	NN
cord-006860-a3b8hyyr	3423	8	from	from	IN
cord-006860-a3b8hyyr	3423	9	venous	venous	JJ
cord-006860-a3b8hyyr	3423	10	and	and	CC
cord-006860-a3b8hyyr	3423	11	capillaryblood	capillaryblood	NN
cord-006860-a3b8hyyr	3423	12	samples	sample	NNS
cord-006860-a3b8hyyr	3423	13	of	of	IN
cord-006860-a3b8hyyr	3423	14	an	an	DT
cord-006860-a3b8hyyr	3423	15	infant	infant	NN
cord-006860-a3b8hyyr	3423	16	on	on	IN
cord-006860-a3b8hyyr	3423	17	phenprocoumon	phenprocoumon	NNP
cord-006860-a3b8hyyr	3423	18	,	,	,
cord-006860-a3b8hyyr	3423	19	starting	start	VBG
cord-006860-a3b8hyyr	3423	20	at	at	IN
cord-006860-a3b8hyyr	3423	21	the	the	DT
cord-006860-a3b8hyyr	3423	22	age	age	NN
cord-006860-a3b8hyyr	3423	23	of	of	IN
cord-006860-a3b8hyyr	3423	24	4	4	CD
cord-006860-a3b8hyyr	3423	25	months	month	NNS
cord-006860-a3b8hyyr	3423	26	.	.	.
cord-006860-a3b8hyyr	3424	1	The	the	DT
cord-006860-a3b8hyyr	3424	2	COAGUCHEK	COAGUCHEK	NNP
cord-006860-a3b8hyyr	3424	3	®	®	POS
cord-006860-a3b8hyyr	3424	4	monitor	monitor	NN
cord-006860-a3b8hyyr	3424	5	from	from	IN
cord-006860-a3b8hyyr	3424	6	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	3424	7	Mannheim	Mannheim	NNP
cord-006860-a3b8hyyr	3424	8	was	be	VBD
cord-006860-a3b8hyyr	3424	9	used	use	VBN
cord-006860-a3b8hyyr	3424	10	.	.	.
cord-006860-a3b8hyyr	3425	1	Choosing	choose	VBG
cord-006860-a3b8hyyr	3425	2	an	an	DT
cord-006860-a3b8hyyr	3425	3	arbitrary	arbitrary	JJ
cord-006860-a3b8hyyr	3425	4	range	range	NN
cord-006860-a3b8hyyr	3425	5	of	of	IN
cord-006860-a3b8hyyr	3425	6	agreement	agreement	NN
cord-006860-a3b8hyyr	3425	7	of	of	IN
cord-006860-a3b8hyyr	3425	8	,	,	,
cord-006860-a3b8hyyr	3425	9	qNR	qnr	IN
cord-006860-a3b8hyyr	3425	10	0.5	0.5	CD
cord-006860-a3b8hyyr	3425	11	for	for	IN
cord-006860-a3b8hyyr	3425	12	both	both	DT
cord-006860-a3b8hyyr	3425	13	determinations	determination	NNS
cord-006860-a3b8hyyr	3425	14	,	,	,
cord-006860-a3b8hyyr	3425	15	81	81	CD
cord-006860-a3b8hyyr	3425	16	%	%	NN
cord-006860-a3b8hyyr	3425	17	of	of	IN
cord-006860-a3b8hyyr	3425	18	the	the	DT
cord-006860-a3b8hyyr	3425	19	measurements	measurement	NNS
cord-006860-a3b8hyyr	3425	20	were	be	VBD
cord-006860-a3b8hyyr	3425	21	within	within	IN
cord-006860-a3b8hyyr	3425	22	the	the	DT
cord-006860-a3b8hyyr	3425	23	defined	define	VBN
cord-006860-a3b8hyyr	3425	24	range	range	NN
cord-006860-a3b8hyyr	3425	25	.	.	.
cord-006860-a3b8hyyr	3426	1	5/6	5/6	CD
cord-006860-a3b8hyyr	3426	2	outliers	outlier	NNS
cord-006860-a3b8hyyr	3426	3	were	be	VBD
cord-006860-a3b8hyyr	3426	4	due	due	JJ
cord-006860-a3b8hyyr	3426	5	to	to	IN
cord-006860-a3b8hyyr	3426	6	low	low	JJ
cord-006860-a3b8hyyr	3426	7	INR	INR	NNP
cord-006860-a3b8hyyr	3426	8	resulting	result	VBG
cord-006860-a3b8hyyr	3426	9	from	from	IN
cord-006860-a3b8hyyr	3426	10	difficulties	difficulty	NNS
cord-006860-a3b8hyyr	3426	11	in	in	IN
cord-006860-a3b8hyyr	3426	12	capillary	capillary	JJ
cord-006860-a3b8hyyr	3426	13	blood	blood	NN
cord-006860-a3b8hyyr	3426	14	sampling	sampling	NN
cord-006860-a3b8hyyr	3426	15	.	.	.
cord-006860-a3b8hyyr	3427	1	The	the	DT
cord-006860-a3b8hyyr	3427	2	degree	degree	NN
cord-006860-a3b8hyyr	3427	3	of	of	IN
cord-006860-a3b8hyyr	3427	4	agreement	agreement	NN
cord-006860-a3b8hyyr	3427	5	increased	increase	VBD
cord-006860-a3b8hyyr	3427	6	when	when	WRB
cord-006860-a3b8hyyr	3427	7	the	the	DT
cord-006860-a3b8hyyr	3427	8	procedure	procedure	NN
cord-006860-a3b8hyyr	3427	9	was	be	VBD
cord-006860-a3b8hyyr	3427	10	performed	perform	VBN
cord-006860-a3b8hyyr	3427	11	at	at	IN
cord-006860-a3b8hyyr	3427	12	least	least	JJS
cord-006860-a3b8hyyr	3427	13	once	once	RB
cord-006860-a3b8hyyr	3427	14	a	a	DT
cord-006860-a3b8hyyr	3427	15	week	week	NN
cord-006860-a3b8hyyr	3427	16	.	.	.
cord-006860-a3b8hyyr	3428	1	In	in	IN
cord-006860-a3b8hyyr	3428	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	3428	3	:	:	:
cord-006860-a3b8hyyr	3428	4	INR	INR	NNP
cord-006860-a3b8hyyr	3428	5	determination	determination	NN
cord-006860-a3b8hyyr	3428	6	with	with	IN
cord-006860-a3b8hyyr	3428	7	a	a	DT
cord-006860-a3b8hyyr	3428	8	portable	portable	JJ
cord-006860-a3b8hyyr	3428	9	monitor	monitor	NN
cord-006860-a3b8hyyr	3428	10	may	may	MD
cord-006860-a3b8hyyr	3428	11	be	be	VB
cord-006860-a3b8hyyr	3428	12	helpful	helpful	JJ
cord-006860-a3b8hyyr	3428	13	in	in	IN
cord-006860-a3b8hyyr	3428	14	home	home	NN
cord-006860-a3b8hyyr	3428	15	monitoring	monitor	VBG
cord-006860-a3b8hyyr	3428	16	oral	oral	JJ
cord-006860-a3b8hyyr	3428	17	an.ticoagulant	an.ticoagulant	JJ
cord-006860-a3b8hyyr	3428	18	therapy	therapy	NN
cord-006860-a3b8hyyr	3428	19	in	in	IN
cord-006860-a3b8hyyr	3428	20	young	young	JJ
cord-006860-a3b8hyyr	3428	21	children	child	NNS
cord-006860-a3b8hyyr	3428	22	.	.	.
cord-006860-a3b8hyyr	3429	1	A	a	DT
cord-006860-a3b8hyyr	3429	2	dose	dose	JJ
cord-006860-a3b8hyyr	3429	3	adjustment	adjustment	NN
cord-006860-a3b8hyyr	3429	4	should	should	MD
cord-006860-a3b8hyyr	3429	5	be	be	VB
cord-006860-a3b8hyyr	3429	6	done	do	VBN
cord-006860-a3b8hyyr	3429	7	only	only	RB
cord-006860-a3b8hyyr	3429	8	on	on	IN
cord-006860-a3b8hyyr	3429	9	the	the	DT
cord-006860-a3b8hyyr	3429	10	base	base	NN
cord-006860-a3b8hyyr	3429	11	of	of	IN
cord-006860-a3b8hyyr	3429	12	INR	INR	NNP
cord-006860-a3b8hyyr	3429	13	determination	determination	NN
cord-006860-a3b8hyyr	3429	14	of	of	IN
cord-006860-a3b8hyyr	3429	15	venous	venous	JJ
cord-006860-a3b8hyyr	3429	16	blood	blood	NN
cord-006860-a3b8hyyr	3429	17	-if	-if	.
cord-006860-a3b8hyyr	3430	1	it	-PRON-	PRP
cord-006860-a3b8hyyr	3430	2	is	be	VBZ
cord-006860-a3b8hyyr	3430	3	considered	consider	VBN
cord-006860-a3b8hyyr	3430	4	the	the	DT
cord-006860-a3b8hyyr	3430	5	gold	gold	JJ
cord-006860-a3b8hyyr	3430	6	standard	standard	NN
cord-006860-a3b8hyyr	3430	7	-to	-to	ADD
cord-006860-a3b8hyyr	3431	1	avoid	avoid	VB
cord-006860-a3b8hyyr	3431	2	over	over	IN
cord-006860-a3b8hyyr	3431	3	-	-	HYPH
cord-006860-a3b8hyyr	3431	4	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3431	5	.	.	.
cord-006860-a3b8hyyr	3432	1	A	a	DT
cord-006860-a3b8hyyr	3432	2	stable	stable	JJ
cord-006860-a3b8hyyr	3432	3	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3432	4	is	be	VBZ
cord-006860-a3b8hyyr	3432	5	one	one	CD
cord-006860-a3b8hyyr	3432	6	of	of	IN
cord-006860-a3b8hyyr	3432	7	the	the	DT
cord-006860-a3b8hyyr	3432	8	most	most	RBS
cord-006860-a3b8hyyr	3432	9	difficult	difficult	JJ
cord-006860-a3b8hyyr	3432	10	tasks	task	NNS
cord-006860-a3b8hyyr	3432	11	in	in	IN
cord-006860-a3b8hyyr	3432	12	attending	attend	VBG
cord-006860-a3b8hyyr	3432	13	patients	patient	NNS
cord-006860-a3b8hyyr	3432	14	with	with	IN
cord-006860-a3b8hyyr	3432	15	heart	heart	NN
cord-006860-a3b8hyyr	3432	16	-	-	HYPH
cord-006860-a3b8hyyr	3432	17	valve	valve	NN
cord-006860-a3b8hyyr	3432	18	-	-	HYPH
cord-006860-a3b8hyyr	3432	19	prosthesis	prosthesis	NN
cord-006860-a3b8hyyr	3432	20	.	.	.
cord-006860-a3b8hyyr	3433	1	If	if	IN
cord-006860-a3b8hyyr	3433	2	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3433	3	times	time	NNS
cord-006860-a3b8hyyr	3433	4	are	be	VBP
cord-006860-a3b8hyyr	3433	5	out	out	IN
cord-006860-a3b8hyyr	3433	6	of	of	IN
cord-006860-a3b8hyyr	3433	7	the	the	DT
cord-006860-a3b8hyyr	3433	8	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	3433	9	range	range	NN
cord-006860-a3b8hyyr	3433	10	,	,	,
cord-006860-a3b8hyyr	3433	11	the	the	DT
cord-006860-a3b8hyyr	3433	12	risk	risk	NN
cord-006860-a3b8hyyr	3433	13	of	of	IN
cord-006860-a3b8hyyr	3433	14	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3433	15	or	or	CC
cord-006860-a3b8hyyr	3433	16	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	3433	17	increases	increase	VBZ
cord-006860-a3b8hyyr	3433	18	disproportionately	disproportionately	RB
cord-006860-a3b8hyyr	3433	19	.	.	.
cord-006860-a3b8hyyr	3434	1	For	for	IN
cord-006860-a3b8hyyr	3434	2	this	this	DT
cord-006860-a3b8hyyr	3434	3	reason	reason	NN
cord-006860-a3b8hyyr	3434	4	any	any	DT
cord-006860-a3b8hyyr	3434	5	improvement	improvement	NN
cord-006860-a3b8hyyr	3434	6	in	in	IN
cord-006860-a3b8hyyr	3434	7	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3434	8	control	control	NN
cord-006860-a3b8hyyr	3434	9	and/or	and/or	CC
cord-006860-a3b8hyyr	3434	10	management	management	NN
cord-006860-a3b8hyyr	3434	11	can	can	MD
cord-006860-a3b8hyyr	3434	12	have	have	VB
cord-006860-a3b8hyyr	3434	13	far	far	RB
cord-006860-a3b8hyyr	3434	14	reaching	reach	VBG
cord-006860-a3b8hyyr	3434	15	consequences	consequence	NNS
cord-006860-a3b8hyyr	3434	16	in	in	IN
cord-006860-a3b8hyyr	3434	17	decreasing	decrease	VBG
cord-006860-a3b8hyyr	3434	18	complications	complication	NNS
cord-006860-a3b8hyyr	3434	19	,	,	,
cord-006860-a3b8hyyr	3434	20	in	in	IN
cord-006860-a3b8hyyr	3434	21	extending	extend	VBG
cord-006860-a3b8hyyr	3434	22	longevity	longevity	NN
cord-006860-a3b8hyyr	3434	23	and	and	CC
cord-006860-a3b8hyyr	3434	24	in	in	IN
cord-006860-a3b8hyyr	3434	25	improving	improve	VBG
cord-006860-a3b8hyyr	3434	26	quality	quality	NN
cord-006860-a3b8hyyr	3434	27	of	of	IN
cord-006860-a3b8hyyr	3434	28	life	life	NN
cord-006860-a3b8hyyr	3434	29	.	.	.
cord-006860-a3b8hyyr	3435	1	For	for	IN
cord-006860-a3b8hyyr	3435	2	the	the	DT
cord-006860-a3b8hyyr	3435	3	first	first	JJ
cord-006860-a3b8hyyr	3435	4	time	time	NN
cord-006860-a3b8hyyr	3435	5	a	a	DT
cord-006860-a3b8hyyr	3435	6	clinical	clinical	JJ
cord-006860-a3b8hyyr	3435	7	trial	trial	NN
cord-006860-a3b8hyyr	3435	8	was	be	VBD
cord-006860-a3b8hyyr	3435	9	started	start	VBN
cord-006860-a3b8hyyr	3435	10	in	in	IN
cord-006860-a3b8hyyr	3435	11	1986	1986	CD
cord-006860-a3b8hyyr	3435	12	and	and	CC
cord-006860-a3b8hyyr	3435	13	continues	continue	VBZ
cord-006860-a3b8hyyr	3435	14	until	until	IN
cord-006860-a3b8hyyr	3435	15	today	today	NN
cord-006860-a3b8hyyr	3435	16	at	at	IN
cord-006860-a3b8hyyr	3435	17	the	the	DT
cord-006860-a3b8hyyr	3435	18	Cardiac	Cardiac	NNP
cord-006860-a3b8hyyr	3435	19	Rehabilitation	Rehabilitation	NNP
cord-006860-a3b8hyyr	3435	20	Center	Center	NNP
cord-006860-a3b8hyyr	3435	21	Bad	Bad	NNP
cord-006860-a3b8hyyr	3435	22	Berleburg	Berleburg	NNP
cord-006860-a3b8hyyr	3435	23	,	,	,
cord-006860-a3b8hyyr	3435	24	Germany	Germany	NNP
cord-006860-a3b8hyyr	3435	25	with	with	IN
cord-006860-a3b8hyyr	3435	26	patients	patient	NNS
cord-006860-a3b8hyyr	3435	27	mainly	mainly	RB
cord-006860-a3b8hyyr	3435	28	after	after	IN
cord-006860-a3b8hyyr	3435	29	heart	heart	NN
cord-006860-a3b8hyyr	3435	30	valve	valve	NN
cord-006860-a3b8hyyr	3435	31	replacement	replacement	NN
cord-006860-a3b8hyyr	3435	32	.	.	.
cord-006860-a3b8hyyr	3436	1	The	the	DT
cord-006860-a3b8hyyr	3436	2	patients	patient	NNS
cord-006860-a3b8hyyr	3436	3	were	be	VBD
cord-006860-a3b8hyyr	3436	4	trained	train	VBN
cord-006860-a3b8hyyr	3436	5	to	to	TO
cord-006860-a3b8hyyr	3436	6	measure	measure	VB
cord-006860-a3b8hyyr	3436	7	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3436	8	own	own	JJ
cord-006860-a3b8hyyr	3436	9	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3436	10	time	time	NN
cord-006860-a3b8hyyr	3436	11	and	and	CC
cord-006860-a3b8hyyr	3436	12	to	to	TO
cord-006860-a3b8hyyr	3436	13	adjust	adjust	VB
cord-006860-a3b8hyyr	3436	14	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3436	15	own	own	JJ
cord-006860-a3b8hyyr	3436	16	dosage	dosage	NN
cord-006860-a3b8hyyr	3436	17	of	of	IN
cord-006860-a3b8hyyr	3436	18	the	the	DT
cord-006860-a3b8hyyr	3436	19	oral	oral	JJ
cord-006860-a3b8hyyr	3436	20	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3436	21	.	.	.
cord-006860-a3b8hyyr	3437	1	Within	within	IN
cord-006860-a3b8hyyr	3437	2	six	six	CD
cord-006860-a3b8hyyr	3437	3	years	year	NNS
cord-006860-a3b8hyyr	3437	4	600	600	CD
cord-006860-a3b8hyyr	3437	5	patients	patient	NNS
cord-006860-a3b8hyyr	3437	6	were	be	VBD
cord-006860-a3b8hyyr	3437	7	trained	train	VBN
cord-006860-a3b8hyyr	3437	8	:	:	:
cord-006860-a3b8hyyr	3437	9	216	216	CD
cord-006860-a3b8hyyr	3437	10	patients	patient	NNS
cord-006860-a3b8hyyr	3437	11	could	could	MD
cord-006860-a3b8hyyr	3437	12	be	be	VB
cord-006860-a3b8hyyr	3437	13	followed	follow	VBN
cord-006860-a3b8hyyr	3437	14	up	up	RP
cord-006860-a3b8hyyr	3437	15	with	with	IN
cord-006860-a3b8hyyr	3437	16	regard	regard	NN
cord-006860-a3b8hyyr	3437	17	to	to	IN
cord-006860-a3b8hyyr	3437	18	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3437	19	selfdetermined	selfdetermine	VBN
cord-006860-a3b8hyyr	3437	20	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3437	21	times	time	NNS
cord-006860-a3b8hyyr	3437	22	.	.	.
cord-006860-a3b8hyyr	3438	1	The	the	DT
cord-006860-a3b8hyyr	3438	2	results	result	NNS
cord-006860-a3b8hyyr	3438	3	were	be	VBD
cord-006860-a3b8hyyr	3438	4	within	within	IN
cord-006860-a3b8hyyr	3438	5	the	the	DT
cord-006860-a3b8hyyr	3438	6	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	3438	7	range	range	NN
cord-006860-a3b8hyyr	3438	8	in	in	IN
cord-006860-a3b8hyyr	3438	9	83.1	83.1	CD
cord-006860-a3b8hyyr	3438	10	%	%	NN
cord-006860-a3b8hyyr	3438	11	of	of	IN
cord-006860-a3b8hyyr	3438	12	the	the	DT
cord-006860-a3b8hyyr	3438	13	measurements	measurement	NNS
cord-006860-a3b8hyyr	3438	14	(	(	-LRB-
cord-006860-a3b8hyyr	3438	15	n=14.812	n=14.812	NN
cord-006860-a3b8hyyr	3438	16	)	)	-RRB-
cord-006860-a3b8hyyr	3438	17	taken	take	VBN
cord-006860-a3b8hyyr	3438	18	by	by	IN
cord-006860-a3b8hyyr	3438	19	the	the	DT
cord-006860-a3b8hyyr	3438	20	patients	patient	NNS
cord-006860-a3b8hyyr	3438	21	themselves	-PRON-	PRP
cord-006860-a3b8hyyr	3438	22	.	.	.
cord-006860-a3b8hyyr	3439	1	On	on	IN
cord-006860-a3b8hyyr	3439	2	average	average	JJ
cord-006860-a3b8hyyr	3439	3	,	,	,
cord-006860-a3b8hyyr	3439	4	the	the	DT
cord-006860-a3b8hyyr	3439	5	patients	patient	NNS
cord-006860-a3b8hyyr	3439	6	who	who	WP
cord-006860-a3b8hyyr	3439	7	determine	determine	VBP
cord-006860-a3b8hyyr	3439	8	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3439	9	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3439	10	time	time	NN
cord-006860-a3b8hyyr	3439	11	themselves	-PRON-	PRP
cord-006860-a3b8hyyr	3439	12	did	do	VBD
cord-006860-a3b8hyyr	3439	13	so	so	RB
cord-006860-a3b8hyyr	3439	14	at	at	IN
cord-006860-a3b8hyyr	3439	15	a	a	DT
cord-006860-a3b8hyyr	3439	16	weekly	weekly	JJ
cord-006860-a3b8hyyr	3439	17	interval	interval	NN
cord-006860-a3b8hyyr	3439	18	.	.	.
cord-006860-a3b8hyyr	3440	1	Neither	neither	DT
cord-006860-a3b8hyyr	3440	2	major	major	JJ
cord-006860-a3b8hyyr	3440	3	bleeding	bleeding	NN
cord-006860-a3b8hyyr	3440	4	nor	nor	CC
cord-006860-a3b8hyyr	3440	5	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	3440	6	complications	complication	NNS
cord-006860-a3b8hyyr	3440	7	could	could	MD
cord-006860-a3b8hyyr	3440	8	be	be	VB
cord-006860-a3b8hyyr	3440	9	observed	observe	VBN
cord-006860-a3b8hyyr	3440	10	in	in	IN
cord-006860-a3b8hyyr	3440	11	the	the	DT
cord-006860-a3b8hyyr	3440	12	205	205	CD
cord-006860-a3b8hyyr	3440	13	patient	patient	NN
cord-006860-a3b8hyyr	3440	14	-	-	HYPH
cord-006860-a3b8hyyr	3440	15	years	year	NNS
cord-006860-a3b8hyyr	3440	16	of	of	IN
cord-006860-a3b8hyyr	3440	17	home	home	NN
cord-006860-a3b8hyyr	3440	18	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3440	19	estimation	estimation	NN
cord-006860-a3b8hyyr	3440	20	.	.	.
cord-006860-a3b8hyyr	3441	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	3441	2	is	be	VBZ
cord-006860-a3b8hyyr	3441	3	to	to	TO
cord-006860-a3b8hyyr	3441	4	be	be	VB
cord-006860-a3b8hyyr	3441	5	hoped	hope	VBN
cord-006860-a3b8hyyr	3441	6	that	that	IN
cord-006860-a3b8hyyr	3441	7	the	the	DT
cord-006860-a3b8hyyr	3441	8	usual	usual	JJ
cord-006860-a3b8hyyr	3441	9	rate	rate	NN
cord-006860-a3b8hyyr	3441	10	of	of	IN
cord-006860-a3b8hyyr	3441	11	complications	complication	NNS
cord-006860-a3b8hyyr	3441	12	can	can	MD
cord-006860-a3b8hyyr	3441	13	be	be	VB
cord-006860-a3b8hyyr	3441	14	reduced	reduce	VBN
cord-006860-a3b8hyyr	3441	15	when	when	WRB
cord-006860-a3b8hyyr	3441	16	patients	patient	NNS
cord-006860-a3b8hyyr	3441	17	determine	determine	VBP
cord-006860-a3b8hyyr	3441	18	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3441	19	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3441	20	time	time	NN
cord-006860-a3b8hyyr	3441	21	themselves	-PRON-	PRP
cord-006860-a3b8hyyr	3441	22	at	at	IN
cord-006860-a3b8hyyr	3441	23	a	a	DT
cord-006860-a3b8hyyr	3441	24	close	close	JJ
cord-006860-a3b8hyyr	3441	25	interval	interval	NN
cord-006860-a3b8hyyr	3441	26	,	,	,
cord-006860-a3b8hyyr	3441	27	resulting	result	VBG
cord-006860-a3b8hyyr	3441	28	in	in	IN
cord-006860-a3b8hyyr	3441	29	more	more	JJR
cord-006860-a3b8hyyr	3441	30	constant	constant	JJ
cord-006860-a3b8hyyr	3441	31	values	value	NNS
cord-006860-a3b8hyyr	3441	32	in	in	IN
cord-006860-a3b8hyyr	3441	33	the	the	DT
cord-006860-a3b8hyyr	3441	34	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	3441	35	range	range	NN
cord-006860-a3b8hyyr	3441	36	and	and	CC
cord-006860-a3b8hyyr	3441	37	slight	slight	JJ
cord-006860-a3b8hyyr	3441	38	corrections	correction	NNS
cord-006860-a3b8hyyr	3441	39	of	of	IN
cord-006860-a3b8hyyr	3441	40	the	the	DT
cord-006860-a3b8hyyr	3441	41	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3441	42	dose	dose	NN
cord-006860-a3b8hyyr	3441	43	.	.	.
cord-006860-a3b8hyyr	3442	1	Home	home	NN
cord-006860-a3b8hyyr	3442	2	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3442	3	estimation	estimation	NN
cord-006860-a3b8hyyr	3442	4	promises	promise	VBZ
cord-006860-a3b8hyyr	3442	5	better	well	JJR
cord-006860-a3b8hyyr	3442	6	quality	quality	NN
cord-006860-a3b8hyyr	3442	7	of	of	IN
cord-006860-a3b8hyyr	3442	8	life	life	NN
cord-006860-a3b8hyyr	3442	9	and	and	CC
cord-006860-a3b8hyyr	3442	10	has	have	VBZ
cord-006860-a3b8hyyr	3442	11	a	a	DT
cord-006860-a3b8hyyr	3442	12	considerable	considerable	JJ
cord-006860-a3b8hyyr	3442	13	potential	potential	NN
cord-006860-a3b8hyyr	3442	14	to	to	TO
cord-006860-a3b8hyyr	3442	15	achieve	achieve	VB
cord-006860-a3b8hyyr	3442	16	this	this	DT
cord-006860-a3b8hyyr	3442	17	goal	goal	NN
cord-006860-a3b8hyyr	3442	18	.	.	.
cord-006860-a3b8hyyr	3443	1	Circulating	circulate	VBG
cord-006860-a3b8hyyr	3443	2	plasma	plasma	NN
cord-006860-a3b8hyyr	3443	3	thrombomodulin	thrombomodulin	NN
cord-006860-a3b8hyyr	3443	4	(	(	-LRB-
cord-006860-a3b8hyyr	3443	5	TM	TM	NNP
cord-006860-a3b8hyyr	3443	6	)	)	-RRB-
cord-006860-a3b8hyyr	3443	7	is	be	VBZ
cord-006860-a3b8hyyr	3443	8	a	a	DT
cord-006860-a3b8hyyr	3443	9	novel	novel	JJ
cord-006860-a3b8hyyr	3443	10	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	3443	11	cell	cell	NN
cord-006860-a3b8hyyr	3443	12	marker	marker	NN
cord-006860-a3b8hyyr	3443	13	,	,	,
cord-006860-a3b8hyyr	3443	14	which	which	WDT
cord-006860-a3b8hyyr	3443	15	may	may	MD
cord-006860-a3b8hyyr	3443	16	reflect	reflect	VB
cord-006860-a3b8hyyr	3443	17	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	3443	18	injury	injury	NN
cord-006860-a3b8hyyr	3443	19	.	.	.
cord-006860-a3b8hyyr	3444	1	TM	TM	NNP
cord-006860-a3b8hyyr	3444	2	acts	act	VBZ
cord-006860-a3b8hyyr	3444	3	as	as	IN
cord-006860-a3b8hyyr	3444	4	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3444	5	receptor	receptor	NN
cord-006860-a3b8hyyr	3444	6	which	which	WDT
cord-006860-a3b8hyyr	3444	7	neutralises	neutralise	VBZ
cord-006860-a3b8hyyr	3444	8	the	the	DT
cord-006860-a3b8hyyr	3444	9	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3444	10	-	-	HYPH
cord-006860-a3b8hyyr	3444	11	forming	form	VBG
cord-006860-a3b8hyyr	3444	12	effect	effect	NN
cord-006860-a3b8hyyr	3444	13	of	of	IN
cord-006860-a3b8hyyr	3444	14	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3444	15	,	,	,
cord-006860-a3b8hyyr	3444	16	and	and	CC
cord-006860-a3b8hyyr	3444	17	also	also	RB
cord-006860-a3b8hyyr	3444	18	accelerates	accelerate	VBZ
cord-006860-a3b8hyyr	3444	19	the	the	DT
cord-006860-a3b8hyyr	3444	20	formation	formation	NN
cord-006860-a3b8hyyr	3444	21	of	of	IN
cord-006860-a3b8hyyr	3444	22	the	the	DT
cord-006860-a3b8hyyr	3444	23	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3444	24	protein	protein	NN
cord-006860-a3b8hyyr	3444	25	C	C	NNP
cord-006860-a3b8hyyr	3444	26	/	/	SYM
cord-006860-a3b8hyyr	3444	27	S	S	NNP
cord-006860-a3b8hyyr	3444	28	pathway	pathway	NN
cord-006860-a3b8hyyr	3444	29	.	.	.
cord-006860-a3b8hyyr	3445	1	TM	TM	NNP
cord-006860-a3b8hyyr	3445	2	therefore	therefore	RB
cord-006860-a3b8hyyr	3445	3	belongs	belong	VBZ
cord-006860-a3b8hyyr	3445	4	to	to	IN
cord-006860-a3b8hyyr	3445	5	the	the	DT
cord-006860-a3b8hyyr	3445	6	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3445	7	defence	defence	NN
cord-006860-a3b8hyyr	3445	8	system	system	NN
cord-006860-a3b8hyyr	3445	9	against	against	IN
cord-006860-a3b8hyyr	3445	10	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3445	11	.	.	.
cord-006860-a3b8hyyr	3446	1	Increased	increase	VBN
cord-006860-a3b8hyyr	3446	2	TM	TM	NNP
cord-006860-a3b8hyyr	3446	3	levels	level	NNS
cord-006860-a3b8hyyr	3446	4	have	have	VBP
cord-006860-a3b8hyyr	3446	5	been	be	VBN
cord-006860-a3b8hyyr	3446	6	described	describe	VBN
cord-006860-a3b8hyyr	3446	7	in	in	IN
cord-006860-a3b8hyyr	3446	8	various	various	JJ
cord-006860-a3b8hyyr	3446	9	diseases	disease	NNS
cord-006860-a3b8hyyr	3446	10	such	such	JJ
cord-006860-a3b8hyyr	3446	11	as	as	IN
cord-006860-a3b8hyyr	3446	12	ARDS	ARDS	NNP
cord-006860-a3b8hyyr	3446	13	,	,	,
cord-006860-a3b8hyyr	3446	14	thromboemboembolic	thromboemboembolic	JJ
cord-006860-a3b8hyyr	3446	15	diseases	disease	NNS
cord-006860-a3b8hyyr	3446	16	,	,	,
cord-006860-a3b8hyyr	3446	17	TTP	TTP	NNP
cord-006860-a3b8hyyr	3446	18	,	,	,
cord-006860-a3b8hyyr	3446	19	diabetes	diabetes	NN
cord-006860-a3b8hyyr	3446	20	,	,	,
cord-006860-a3b8hyyr	3446	21	LE	LE	NNP
cord-006860-a3b8hyyr	3446	22	and	and	CC
cord-006860-a3b8hyyr	3446	23	CML	CML	NNP
cord-006860-a3b8hyyr	3447	1	reflecting	reflect	VBG
cord-006860-a3b8hyyr	3447	2	alterations	alteration	NNS
cord-006860-a3b8hyyr	3447	3	of	of	IN
cord-006860-a3b8hyyr	3447	4	the	the	DT
cord-006860-a3b8hyyr	3447	5	vascular	vascular	JJ
cord-006860-a3b8hyyr	3447	6	system	system	NN
cord-006860-a3b8hyyr	3447	7	at	at	IN
cord-006860-a3b8hyyr	3447	8	the	the	DT
cord-006860-a3b8hyyr	3447	9	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	3447	10	level	level	NN
cord-006860-a3b8hyyr	3447	11	.	.	.
cord-006860-a3b8hyyr	3448	1	To	to	TO
cord-006860-a3b8hyyr	3448	2	find	find	VB
cord-006860-a3b8hyyr	3448	3	out	out	RP
cord-006860-a3b8hyyr	3448	4	to	to	IN
cord-006860-a3b8hyyr	3448	5	what	what	WDT
cord-006860-a3b8hyyr	3448	6	extent	extent	NN
cord-006860-a3b8hyyr	3448	7	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	3448	8	catheterisation	catheterisation	NNP
cord-006860-a3b8hyyr	3448	9	imtates	imtates	NNPS
cord-006860-a3b8hyyr	3448	10	vascular	vascular	JJ
cord-006860-a3b8hyyr	3448	11	endothelium	endothelium	NN
cord-006860-a3b8hyyr	3448	12	,	,	,
cord-006860-a3b8hyyr	3448	13	TM	TM	NNP
cord-006860-a3b8hyyr	3448	14	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3448	15	(	(	-LRB-
cord-006860-a3b8hyyr	3448	16	Stago	Stago	NNP
cord-006860-a3b8hyyr	3448	17	,	,	,
cord-006860-a3b8hyyr	3448	18	Asnieres	Asnieres	NNP
cord-006860-a3b8hyyr	3448	19	,	,	,
cord-006860-a3b8hyyr	3448	20	France	France	NNP
cord-006860-a3b8hyyr	3448	21	:	:	:
cord-006860-a3b8hyyr	3448	22	x	x	SYM
cord-006860-a3b8hyyr	3448	23	10	10	CD
cord-006860-a3b8hyyr	3448	24	3	3	CD
cord-006860-a3b8hyyr	3448	25	IU	IU	NNP
cord-006860-a3b8hyyr	3448	26	/	/	SYM
cord-006860-a3b8hyyr	3448	27	ml	ml	NN
cord-006860-a3b8hyyr	3448	28	)	)	-RRB-
cord-006860-a3b8hyyr	3448	29	were	be	VBD
cord-006860-a3b8hyyr	3448	30	investigated	investigate	VBN
cord-006860-a3b8hyyr	3448	31	prospectively	prospectively	RB
cord-006860-a3b8hyyr	3448	32	in	in	IN
cord-006860-a3b8hyyr	3448	33	58	58	CD
cord-006860-a3b8hyyr	3448	34	infants	infant	NNS
cord-006860-a3b8hyyr	3448	35	and	and	CC
cord-006860-a3b8hyyr	3448	36	children	child	NNS
cord-006860-a3b8hyyr	3448	37	(	(	-LRB-
cord-006860-a3b8hyyr	3448	38	three	three	CD
cord-006860-a3b8hyyr	3448	39	days	day	NNS
cord-006860-a3b8hyyr	3448	40	-16	-16	NNP
cord-006860-a3b8hyyr	3448	41	years	year	NNS
cord-006860-a3b8hyyr	3448	42	)	)	-RRB-
cord-006860-a3b8hyyr	3448	43	.	.	.
cord-006860-a3b8hyyr	3449	1	Blood	blood	NN
cord-006860-a3b8hyyr	3449	2	samples	sample	NNS
cord-006860-a3b8hyyr	3449	3	were	be	VBD
cord-006860-a3b8hyyr	3449	4	drawn	draw	VBN
cord-006860-a3b8hyyr	3449	5	before	before	IN
cord-006860-a3b8hyyr	3449	6	the	the	DT
cord-006860-a3b8hyyr	3449	7	intervention	intervention	NN
cord-006860-a3b8hyyr	3449	8	,	,	,
cord-006860-a3b8hyyr	3449	9	immediately	immediately	RB
cord-006860-a3b8hyyr	3449	10	at	at	IN
cord-006860-a3b8hyyr	3449	11	the	the	DT
cord-006860-a3b8hyyr	3449	12	end	end	NN
cord-006860-a3b8hyyr	3449	13	and	and	CC
cord-006860-a3b8hyyr	3449	14	24	24	CD
cord-006860-a3b8hyyr	3449	15	h	h	NN
cord-006860-a3b8hyyr	3449	16	later	later	RB
cord-006860-a3b8hyyr	3449	17	,	,	,
cord-006860-a3b8hyyr	3449	18	snap	snap	VB
cord-006860-a3b8hyyr	3449	19	frozen	frozen	JJ
cord-006860-a3b8hyyr	3449	20	(	(	-LRB-
cord-006860-a3b8hyyr	3449	21	-70	-70	NN
cord-006860-a3b8hyyr	3449	22	°	°	NNP
cord-006860-a3b8hyyr	3449	23	C	C	NNP
cord-006860-a3b8hyyr	3449	24	)	)	-RRB-
cord-006860-a3b8hyyr	3449	25	and	and	CC
cord-006860-a3b8hyyr	3449	26	investigated	investigate	VBN
cord-006860-a3b8hyyr	3449	27	serially	serially	RB
cord-006860-a3b8hyyr	3449	28	in	in	IN
cord-006860-a3b8hyyr	3449	29	dublicate	dublicate	NNP
cord-006860-a3b8hyyr	3449	30	six	six	CD
cord-006860-a3b8hyyr	3449	31	weeks	week	NNS
cord-006860-a3b8hyyr	3449	32	-3	-3	NNP
cord-006860-a3b8hyyr	3449	33	months	month	NNS
cord-006860-a3b8hyyr	3449	34	later	later	RB
cord-006860-a3b8hyyr	3449	35	.	.	.
cord-006860-a3b8hyyr	3450	1	The	the	DT
cord-006860-a3b8hyyr	3450	2	results	result	NNS
cord-006860-a3b8hyyr	3450	3	(	(	-LRB-
cord-006860-a3b8hyyr	3450	4	median	median	NN
cord-006860-a3b8hyyr	3450	5	and	and	CC
cord-006860-a3b8hyyr	3450	6	range	range	NN
cord-006860-a3b8hyyr	3450	7	values	value	NNS
cord-006860-a3b8hyyr	3450	8	)	)	-RRB-
cord-006860-a3b8hyyr	3450	9	are	be	VBP
cord-006860-a3b8hyyr	3450	10	shown	show	VBN
cord-006860-a3b8hyyr	3450	11	in	in	IN
cord-006860-a3b8hyyr	3450	12	the	the	DT
cord-006860-a3b8hyyr	3450	13	Enhanced	Enhanced	NNP
cord-006860-a3b8hyyr	3450	14	TM	TM	NNP
cord-006860-a3b8hyyr	3450	15	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3450	16	immedately	immedately	RB
cord-006860-a3b8hyyr	3450	17	after	after	IN
cord-006860-a3b8hyyr	3450	18	the	the	DT
cord-006860-a3b8hyyr	3450	19	operative	operative	JJ
cord-006860-a3b8hyyr	3450	20	intervention	intervention	NN
cord-006860-a3b8hyyr	3450	21	,	,	,
cord-006860-a3b8hyyr	3450	22	followed	follow	VBN
cord-006860-a3b8hyyr	3450	23	by	by	IN
cord-006860-a3b8hyyr	3450	24	normalisation	normalisation	NN
cord-006860-a3b8hyyr	3450	25	within	within	IN
cord-006860-a3b8hyyr	3450	26	24	24	CD
cord-006860-a3b8hyyr	3450	27	h	h	NNP
cord-006860-a3b8hyyr	3450	28	,	,	,
cord-006860-a3b8hyyr	3450	29	indicates	indicate	VBZ
cord-006860-a3b8hyyr	3450	30	that	that	IN
cord-006860-a3b8hyyr	3450	31	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	3450	32	catheterisation	catheterisation	NN
cord-006860-a3b8hyyr	3450	33	in	in	IN
cord-006860-a3b8hyyr	3450	34	pediatric	pediatric	JJ
cord-006860-a3b8hyyr	3450	35	patients	patient	NNS
cord-006860-a3b8hyyr	3450	36	rather	rather	RB
cord-006860-a3b8hyyr	3450	37	leads	lead	VBZ
cord-006860-a3b8hyyr	3450	38	to	to	IN
cord-006860-a3b8hyyr	3450	39	a	a	DT
cord-006860-a3b8hyyr	3450	40	short	short	JJ
cord-006860-a3b8hyyr	3450	41	lasting	lasting	JJ
cord-006860-a3b8hyyr	3450	42	irritation	irritation	NN
cord-006860-a3b8hyyr	3450	43	of	of	IN
cord-006860-a3b8hyyr	3450	44	the	the	DT
cord-006860-a3b8hyyr	3450	45	vascalar	vascalar	JJ
cord-006860-a3b8hyyr	3450	46	endothelium	endothelium	NN
cord-006860-a3b8hyyr	3450	47	than	than	IN
cord-006860-a3b8hyyr	3450	48	to	to	TO
cord-006860-a3b8hyyr	3450	49	severe	severe	VB
cord-006860-a3b8hyyr	3450	50	irreversible	irreversible	JJ
cord-006860-a3b8hyyr	3450	51	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	3450	52	damage	damage	NN
cord-006860-a3b8hyyr	3450	53	.	.	.
cord-006860-a3b8hyyr	3451	1	Recently	recently	RB
cord-006860-a3b8hyyr	3451	2	in	in	IN
cord-006860-a3b8hyyr	3451	3	an	an	DT
cord-006860-a3b8hyyr	3451	4	al	al	NNP
cord-006860-a3b8hyyr	3451	5	=	=	SYM
cord-006860-a3b8hyyr	3451	6	Wl	Wl	NNP
cord-006860-a3b8hyyr	3451	7	"	"	''
cord-006860-a3b8hyyr	3451	8	based	base	VBN
cord-006860-a3b8hyyr	3451	9	method	method	NN
cord-006860-a3b8hyyr	3451	10	Dahlb	Dahlb	NNP
cord-006860-a3b8hyyr	3451	11	~	~	NFP
cord-006860-a3b8hyyr	3451	12	ick	ick	UH
cord-006860-a3b8hyyr	3451	13	et	et	NNP
cord-006860-a3b8hyyr	3451	14	al	al	NNP
cord-006860-a3b8hyyr	3451	15	described	describe	VBD
cord-006860-a3b8hyyr	3451	16	in	in	IN
cord-006860-a3b8hyyr	3451	17	vitro	vitro	FW
cord-006860-a3b8hyyr	3451	18	resistance	resistance	NN
cord-006860-a3b8hyyr	3451	19	to	to	IN
cord-006860-a3b8hyyr	3451	20	the	the	DT
cord-006860-a3b8hyyr	3451	21	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3451	22	effect	effect	NN
cord-006860-a3b8hyyr	3451	23	of	of	IN
cord-006860-a3b8hyyr	3451	24	activated	activate	VBN
cord-006860-a3b8hyyr	3451	25	protein	protein	NN
cord-006860-a3b8hyyr	3451	26	C	C	NNP
cord-006860-a3b8hyyr	3451	27	(	(	-LRB-
cord-006860-a3b8hyyr	3451	28	APC	APC	NNP
cord-006860-a3b8hyyr	3451	29	)	)	-RRB-
cord-006860-a3b8hyyr	3451	30	in	in	IN
cord-006860-a3b8hyyr	3451	31	thrombophilic	thrombophilic	JJ
cord-006860-a3b8hyyr	3451	32	adult	adult	NN
cord-006860-a3b8hyyr	3451	33	patients	patient	NNS
cord-006860-a3b8hyyr	3451	34	.	.	.
cord-006860-a3b8hyyr	3452	1	APCR	APCR	NNP
cord-006860-a3b8hyyr	3452	2	is	be	VBZ
cord-006860-a3b8hyyr	3452	3	in	in	IN
cord-006860-a3b8hyyr	3452	4	the	the	DT
cord-006860-a3b8hyyr	3452	5	majority	majority	NN
cord-006860-a3b8hyyr	3452	6	of	of	IN
cord-006860-a3b8hyyr	3452	7	cases	case	NNS
cord-006860-a3b8hyyr	3452	8	associated	associate	VBN
cord-006860-a3b8hyyr	3452	9	with	with	IN
cord-006860-a3b8hyyr	3452	10	the	the	DT
cord-006860-a3b8hyyr	3452	11	Arg	Arg	NNP
cord-006860-a3b8hyyr	3452	12	506	506	CD
cord-006860-a3b8hyyr	3452	13	Gin	Gin	NNP
cord-006860-a3b8hyyr	3452	14	point	point	NN
cord-006860-a3b8hyyr	3452	15	mutation	mutation	NN
cord-006860-a3b8hyyr	3452	16	in	in	IN
cord-006860-a3b8hyyr	3452	17	the	the	DT
cord-006860-a3b8hyyr	3452	18	factor	factor	NN
cord-006860-a3b8hyyr	3452	19	V	v	NN
cord-006860-a3b8hyyr	3452	20	gene	gene	NN
cord-006860-a3b8hyyr	3452	21	.	.	.
cord-006860-a3b8hyyr	3453	1	Concerning	concern	VBG
cord-006860-a3b8hyyr	3453	2	the	the	DT
cord-006860-a3b8hyyr	3453	3	special	special	JJ
cord-006860-a3b8hyyr	3453	4	properties	property	NNS
cord-006860-a3b8hyyr	3453	5	of	of	IN
cord-006860-a3b8hyyr	3453	6	the	the	DT
cord-006860-a3b8hyyr	3453	7	neonatal	neonatal	JJ
cord-006860-a3b8hyyr	3453	8	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	3453	9	system	system	NN
cord-006860-a3b8hyyr	3453	10	(	(	-LRB-
cord-006860-a3b8hyyr	3453	11	low	low	JJ
cord-006860-a3b8hyyr	3453	12	vitamin	vitamin	NN
cord-006860-a3b8hyyr	3453	13	K	k	NN
cord-006860-a3b8hyyr	3453	14	dependent	dependent	JJ
cord-006860-a3b8hyyr	3453	15	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3453	16	factors	factor	NNS
cord-006860-a3b8hyyr	3453	17	,	,	,
cord-006860-a3b8hyyr	3453	18	physiological	physiological	JJ
cord-006860-a3b8hyyr	3453	19	prolongation	prolongation	NN
cord-006860-a3b8hyyr	3453	20	of	of	IN
cord-006860-a3b8hyyr	3453	21	the	the	DT
cord-006860-a3b8hyyr	3453	22	PT	pt	NN
cord-006860-a3b8hyyr	3453	23	and	and	CC
cord-006860-a3b8hyyr	3453	24	aPTF	aptf	NN
cord-006860-a3b8hyyr	3453	25	)	)	-RRB-
cord-006860-a3b8hyyr	3454	1	we	-PRON-	PRP
cord-006860-a3b8hyyr	3454	2	adjusted	adjust	VBD
cord-006860-a3b8hyyr	3454	3	this	this	DT
cord-006860-a3b8hyyr	3454	4	aP'IT	aP'IT	NNP
cord-006860-a3b8hyyr	3454	5	based	base	VBN
cord-006860-a3b8hyyr	3454	6	method	method	NN
cord-006860-a3b8hyyr	3454	7	(	(	-LRB-
cord-006860-a3b8hyyr	3454	8	Chromogenix	Chromogenix	NNP
cord-006860-a3b8hyyr	3454	9	,	,	,
cord-006860-a3b8hyyr	3454	10	M~,lndal	m~,lndal	NN
cord-006860-a3b8hyyr	3454	11	,	,	,
cord-006860-a3b8hyyr	3454	12	Sweden	Sweden	NNP
cord-006860-a3b8hyyr	3454	13	)	)	-RRB-
cord-006860-a3b8hyyr	3454	14	to	to	IN
cord-006860-a3b8hyyr	3454	15	neonatal	neonatal	JJ
cord-006860-a3b8hyyr	3454	16	requirements	requirement	NNS
cord-006860-a3b8hyyr	3454	17	:	:	:
cord-006860-a3b8hyyr	3454	18	APCR	APCR	NNP
cord-006860-a3b8hyyr	3454	19	was	be	VBD
cord-006860-a3b8hyyr	3454	20	measured	measure	VBN
cord-006860-a3b8hyyr	3454	21	in	in	IN
cord-006860-a3b8hyyr	3454	22	120	120	CD
cord-006860-a3b8hyyr	3454	23	healthy	healthy	JJ
cord-006860-a3b8hyyr	3454	24	infants	infant	NNS
cord-006860-a3b8hyyr	3454	25	according	accord	VBG
cord-006860-a3b8hyyr	3454	26	to	to	IN
cord-006860-a3b8hyyr	3454	27	Dahlb~	dahlb~	DT
cord-006860-a3b8hyyr	3455	1	ck	ck	NNP
cord-006860-a3b8hyyr	3455	2	.	.	.
cord-006860-a3b8hyyr	3456	1	The	the	DT
cord-006860-a3b8hyyr	3456	2	results	result	NNS
cord-006860-a3b8hyyr	3456	3	were	be	VBD
cord-006860-a3b8hyyr	3456	4	expressed	express	VBN
cord-006860-a3b8hyyr	3456	5	as	as	IN
cord-006860-a3b8hyyr	3456	6	APC	APC	NNP
cord-006860-a3b8hyyr	3456	7	-	-	HYPH
cord-006860-a3b8hyyr	3456	8	ratios	ratio	NNS
cord-006860-a3b8hyyr	3456	9	:	:	:
cord-006860-a3b8hyyr	3456	10	Clotting	clotting	NN
cord-006860-a3b8hyyr	3456	11	time	time	NN
cord-006860-a3b8hyyr	3456	12	obtained	obtain	VBN
cord-006860-a3b8hyyr	3456	13	in	in	IN
cord-006860-a3b8hyyr	3456	14	a	a	DT
cord-006860-a3b8hyyr	3456	15	1:1	1:1	CD
cord-006860-a3b8hyyr	3456	16	,	,	,
cord-006860-a3b8hyyr	3456	17	1:5	1:5	CD
cord-006860-a3b8hyyr	3456	18	and	and	CC
cord-006860-a3b8hyyr	3456	19	1:11	1:11	CD
cord-006860-a3b8hyyr	3456	20	dilution	dilution	NN
cord-006860-a3b8hyyr	3456	21	with	with	IN
cord-006860-a3b8hyyr	3456	22	factor	factor	NN
cord-006860-a3b8hyyr	3456	23	V	v	NN
cord-006860-a3b8hyyr	3456	24	deficient	deficient	JJ
cord-006860-a3b8hyyr	3456	25	plasma	plasma	NN
cord-006860-a3b8hyyr	3456	26	(	(	-LRB-
cord-006860-a3b8hyyr	3456	27	Instrumentation	Instrumentation	NNP
cord-006860-a3b8hyyr	3456	28	Laboratory	Laboratory	NNP
cord-006860-a3b8hyyr	3456	29	Munich	Munich	NNP
cord-006860-a3b8hyyr	3456	30	.	.	.
cord-006860-a3b8hyyr	3457	1	Germany	Germany	NNP
cord-006860-a3b8hyyr	3457	2	)	)	-RRB-
cord-006860-a3b8hyyr	3457	3	using	use	VBG
cord-006860-a3b8hyyr	3457	4	the	the	DT
cord-006860-a3b8hyyr	3457	5	APC	APC	NNP
cord-006860-a3b8hyyr	3457	6	/	/	SYM
cord-006860-a3b8hyyr	3457	7	CaCI2solution	caci2solution	NN
cord-006860-a3b8hyyr	3457	8	divided	divide	VBN
cord-006860-a3b8hyyr	3457	9	by	by	IN
cord-006860-a3b8hyyr	3457	10	clotting	clot	VBG
cord-006860-a3b8hyyr	3457	11	time	time	NN
cord-006860-a3b8hyyr	3457	12	obtained	obtain	VBN
cord-006860-a3b8hyyr	3457	13	with	with	IN
cord-006860-a3b8hyyr	3457	14	CaC12	cac12	NN
cord-006860-a3b8hyyr	3457	15	in	in	IN
cord-006860-a3b8hyyr	3457	16	the	the	DT
cord-006860-a3b8hyyr	3457	17	same	same	JJ
cord-006860-a3b8hyyr	3457	18	I:1	I:1	NNP
cord-006860-a3b8hyyr	3457	19	,	,	,
cord-006860-a3b8hyyr	3457	20	1:5	1:5	CD
cord-006860-a3b8hyyr	3457	21	and	and	CC
cord-006860-a3b8hyyr	3457	22	1:11	1:11	CD
cord-006860-a3b8hyyr	3457	23	dilution	dilution	NN
cord-006860-a3b8hyyr	3457	24	.	.	.
cord-006860-a3b8hyyr	3458	1	In	in	IN
cord-006860-a3b8hyyr	3458	2	addition	addition	NN
cord-006860-a3b8hyyr	3458	3	,	,	,
cord-006860-a3b8hyyr	3458	4	plasma	plasma	NN
cord-006860-a3b8hyyr	3458	5	of	of	IN
cord-006860-a3b8hyyr	3458	6	24	24	CD
cord-006860-a3b8hyyr	3458	7	neonates	neonate	NNS
cord-006860-a3b8hyyr	3458	8	with	with	IN
cord-006860-a3b8hyyr	3458	9	septicaemia	septicaemia	NN
cord-006860-a3b8hyyr	3458	10	were	be	VBD
cord-006860-a3b8hyyr	3458	11	investigated	investigate	VBN
cord-006860-a3b8hyyr	3458	12	and	and	CC
cord-006860-a3b8hyyr	3458	13	data	datum	NNS
cord-006860-a3b8hyyr	3458	14	of	of	IN
cord-006860-a3b8hyyr	3458	15	18	18	CD
cord-006860-a3b8hyyr	3458	16	infants	infant	NNS
cord-006860-a3b8hyyr	3458	17	aged	age	VBN
cord-006860-a3b8hyyr	3458	18	birth	birth	NN
cord-006860-a3b8hyyr	3458	19	-three	-three	CD
cord-006860-a3b8hyyr	3458	20	months	month	NNS
cord-006860-a3b8hyyr	3458	21	with	with	IN
cord-006860-a3b8hyyr	3458	22	Arg	Arg	NNP
cord-006860-a3b8hyyr	3458	23	506	506	CD
cord-006860-a3b8hyyr	3458	24	Gin	Gin	NNP
cord-006860-a3b8hyyr	3458	25	+	+	CC
cord-006860-a3b8hyyr	3459	1	/-were	/-were	,
cord-006860-a3b8hyyr	3459	2	shown	show	VBN
cord-006860-a3b8hyyr	3459	3	.	.	.
cord-006860-a3b8hyyr	3460	1	The	the	DT
cord-006860-a3b8hyyr	3460	2	Arg	arg	NN
cord-006860-a3b8hyyr	3460	3	506	506	CD
cord-006860-a3b8hyyr	3460	4	GIn	GIn	NNS
cord-006860-a3b8hyyr	3460	5	mutation	mutation	NN
cord-006860-a3b8hyyr	3460	6	of	of	IN
cord-006860-a3b8hyyr	3460	7	the	the	DT
cord-006860-a3b8hyyr	3460	8	factor	factor	NN
cord-006860-a3b8hyyr	3460	9	V	V	NNP
cord-006860-a3b8hyyr	3460	10	gene	gene	NN
cord-006860-a3b8hyyr	3460	11	was	be	VBD
cord-006860-a3b8hyyr	3460	12	assayed	assay	VBN
cord-006860-a3b8hyyr	3460	13	by	by	IN
cord-006860-a3b8hyyr	3460	14	amplification	amplification	NN
cord-006860-a3b8hyyr	3460	15	of	of	IN
cord-006860-a3b8hyyr	3460	16	the	the	DT
cord-006860-a3b8hyyr	3460	17	DNA	dna	NN
cord-006860-a3b8hyyr	3460	18	samples	sample	NNS
cord-006860-a3b8hyyr	3460	19	by	by	IN
cord-006860-a3b8hyyr	3460	20	PCR	PCR	NNP
cord-006860-a3b8hyyr	3460	21	followed	follow	VBN
cord-006860-a3b8hyyr	3460	22	by	by	IN
cord-006860-a3b8hyyr	3460	23	digestion	digestion	NN
cord-006860-a3b8hyyr	3460	24	of	of	IN
cord-006860-a3b8hyyr	3460	25	the	the	DT
cord-006860-a3b8hyyr	3460	26	amplified	amplify	VBN
cord-006860-a3b8hyyr	3460	27	products	product	NNS
cord-006860-a3b8hyyr	3460	28	with	with	IN
cord-006860-a3b8hyyr	3460	29	the	the	DT
cord-006860-a3b8hyyr	3460	30	restriction	restriction	NN
cord-006860-a3b8hyyr	3460	31	enzyme	enzyme	NN
cord-006860-a3b8hyyr	3460	32	Mnl	Mnl	NNP
cord-006860-a3b8hyyr	3460	33	I.	I.	NNP
cord-006860-a3b8hyyr	3460	34	Results	result	NNS
cord-006860-a3b8hyyr	3460	35	were	be	VBD
cord-006860-a3b8hyyr	3460	36	confirmed	confirm	VBN
cord-006860-a3b8hyyr	3460	37	by	by	IN
cord-006860-a3b8hyyr	3460	38	SSCP	SSCP	NNP
cord-006860-a3b8hyyr	3460	39	-analysis	-analysis	JJ
cord-006860-a3b8hyyr	3460	40	or	or	CC
cord-006860-a3b8hyyr	3460	41	by	by	IN
cord-006860-a3b8hyyr	3460	42	direct	direct	JJ
cord-006860-a3b8hyyr	3460	43	sequencing	sequencing	NN
cord-006860-a3b8hyyr	3460	44	of	of	IN
cord-006860-a3b8hyyr	3460	45	DNA	dna	NN
cord-006860-a3b8hyyr	3460	46	from	from	IN
cord-006860-a3b8hyyr	3460	47	patients	patient	NNS
cord-006860-a3b8hyyr	3460	48	with	with	IN
cord-006860-a3b8hyyr	3460	49	APCR	APCR	NNP
cord-006860-a3b8hyyr	3460	50	.	.	.
cord-006860-a3b8hyyr	3461	1	Results	result	NNS
cord-006860-a3b8hyyr	3461	2	are	be	VBP
cord-006860-a3b8hyyr	3461	3	shown	show	VBN
cord-006860-a3b8hyyr	3461	4	in	in	IN
cord-006860-a3b8hyyr	3461	5	the	the	DT
cord-006860-a3b8hyyr	3461	6	1.6(1.4	1.6(1.4	CD
cord-006860-a3b8hyyr	3461	7	-	-	SYM
cord-006860-a3b8hyyr	3461	8	1.95	1.95	CD
cord-006860-a3b8hyyr	3461	9	)	)	-RRB-
cord-006860-a3b8hyyr	3462	1	Neonates	neonate	NNS
cord-006860-a3b8hyyr	3462	2	and	and	CC
cord-006860-a3b8hyyr	3462	3	infants	infant	NNS
cord-006860-a3b8hyyr	3462	4	were	be	VBD
cord-006860-a3b8hyyr	3462	5	considered	consider	VBN
cord-006860-a3b8hyyr	3462	6	to	to	TO
cord-006860-a3b8hyyr	3462	7	be	be	VB
cord-006860-a3b8hyyr	3462	8	APCR	APCR	NNP
cord-006860-a3b8hyyr	3462	9	when	when	WRB
cord-006860-a3b8hyyr	3462	10	the	the	DT
cord-006860-a3b8hyyr	3462	11	aPTT	aptt	CD
cord-006860-a3b8hyyr	3462	12	ratio	ratio	NN
cord-006860-a3b8hyyr	3462	13	was	be	VBD
cord-006860-a3b8hyyr	3462	14	<	<	XX
cord-006860-a3b8hyyr	3462	15	or	or	CC
cord-006860-a3b8hyyr	3462	16	=	=	SYM
cord-006860-a3b8hyyr	3462	17	2	2	CD
cord-006860-a3b8hyyr	3462	18	.	.	.
cord-006860-a3b8hyyr	3463	1	Concerning	concern	VBG
cord-006860-a3b8hyyr	3463	2	the	the	DT
cord-006860-a3b8hyyr	3463	3	special	special	JJ
cord-006860-a3b8hyyr	3463	4	properties	property	NNS
cord-006860-a3b8hyyr	3463	5	of	of	IN
cord-006860-a3b8hyyr	3463	6	the	the	DT
cord-006860-a3b8hyyr	3463	7	neonatal	neonatal	JJ
cord-006860-a3b8hyyr	3463	8	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	3463	9	system	system	NN
cord-006860-a3b8hyyr	3463	10	,	,	,
cord-006860-a3b8hyyr	3463	11	our	-PRON-	PRP$
cord-006860-a3b8hyyr	3463	12	data	datum	NNS
cord-006860-a3b8hyyr	3463	13	show	show	VBP
cord-006860-a3b8hyyr	3463	14	concordance	concordance	NN
cord-006860-a3b8hyyr	3463	15	with	with	IN
cord-006860-a3b8hyyr	3463	16	the	the	DT
cord-006860-a3b8hyyr	3463	17	PCR	PCR	NNP
cord-006860-a3b8hyyr	3463	18	method	method	NN
cord-006860-a3b8hyyr	3463	19	in	in	IN
cord-006860-a3b8hyyr	3463	20	neonates	neonate	NNS
cord-006860-a3b8hyyr	3463	21	and	and	CC
cord-006860-a3b8hyyr	3463	22	infants	infant	NNS
cord-006860-a3b8hyyr	3463	23	only	only	RB
cord-006860-a3b8hyyr	3463	24	,	,	,
cord-006860-a3b8hyyr	3463	25	when	when	WRB
cord-006860-a3b8hyyr	3463	26	the	the	DT
cord-006860-a3b8hyyr	3463	27	aPTT	aptt	NN
cord-006860-a3b8hyyr	3463	28	based	base	VBN
cord-006860-a3b8hyyr	3463	29	method	method	NN
cord-006860-a3b8hyyr	3463	30	was	be	VBD
cord-006860-a3b8hyyr	3463	31	performed	perform	VBN
cord-006860-a3b8hyyr	3463	32	in	in	IN
cord-006860-a3b8hyyr	3463	33	the	the	DT
cord-006860-a3b8hyyr	3463	34	I	i	NN
cord-006860-a3b8hyyr	3463	35	:	:	:
cord-006860-a3b8hyyr	3463	36	11	11	CD
cord-006860-a3b8hyyr	3463	37	plasma	plasma	NN
cord-006860-a3b8hyyr	3463	38	dilution	dilution	NN
cord-006860-a3b8hyyr	3463	39	.	.	.
cord-006860-a3b8hyyr	3464	1	Case	case	NN
cord-006860-a3b8hyyr	3464	2	report	report	VB
cord-006860-a3b8hyyr	3465	1	:	:	:
cord-006860-a3b8hyyr	3465	2	We	-PRON-	PRP
cord-006860-a3b8hyyr	3465	3	report	report	VBP
cord-006860-a3b8hyyr	3465	4	on	on	IN
cord-006860-a3b8hyyr	3465	5	an	an	DT
cord-006860-a3b8hyyr	3465	6	8-year	8-year	JJ
cord-006860-a3b8hyyr	3465	7	old	old	JJ
cord-006860-a3b8hyyr	3465	8	boy	boy	NN
cord-006860-a3b8hyyr	3465	9	with	with	IN
cord-006860-a3b8hyyr	3465	10	severe	severe	JJ
cord-006860-a3b8hyyr	3465	11	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	3465	12	B	b	NN
cord-006860-a3b8hyyr	3465	13	and	and	CC
cord-006860-a3b8hyyr	3465	14	frequent	frequent	JJ
cord-006860-a3b8hyyr	3465	15	screaming	screaming	NN
cord-006860-a3b8hyyr	3465	16	at	at	IN
cord-006860-a3b8hyyr	3465	17	night	night	NN
cord-006860-a3b8hyyr	3465	18	.	.	.
cord-006860-a3b8hyyr	3466	1	EEG	EEG	NNP
cord-006860-a3b8hyyr	3466	2	showed	show	VBD
cord-006860-a3b8hyyr	3466	3	spike	spike	NN
cord-006860-a3b8hyyr	3466	4	wave	wave	NN
cord-006860-a3b8hyyr	3466	5	activity	activity	NN
cord-006860-a3b8hyyr	3466	6	,	,	,
cord-006860-a3b8hyyr	3466	7	starting	start	VBG
cord-006860-a3b8hyyr	3466	8	from	from	IN
cord-006860-a3b8hyyr	3466	9	the	the	DT
cord-006860-a3b8hyyr	3466	10	temporal	temporal	JJ
cord-006860-a3b8hyyr	3466	11	lobe	lobe	NN
cord-006860-a3b8hyyr	3466	12	,	,	,
cord-006860-a3b8hyyr	3466	13	but	but	CC
cord-006860-a3b8hyyr	3466	14	generalizing	generalize	VBG
cord-006860-a3b8hyyr	3466	15	within	within	IN
cord-006860-a3b8hyyr	3466	16	seconds	second	NNS
cord-006860-a3b8hyyr	3466	17	.	.	.
cord-006860-a3b8hyyr	3467	1	Complex	complex	JJ
cord-006860-a3b8hyyr	3467	2	partial	partial	JJ
cord-006860-a3b8hyyr	3467	3	seizures	seizure	NNS
cord-006860-a3b8hyyr	3467	4	were	be	VBD
cord-006860-a3b8hyyr	3467	5	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	3467	6	and	and	CC
cord-006860-a3b8hyyr	3467	7	therapy	therapy	NN
cord-006860-a3b8hyyr	3467	8	with	with	IN
cord-006860-a3b8hyyr	3467	9	carbamazepine	carbamazepine	NN
cord-006860-a3b8hyyr	3467	10	was	be	VBD
cord-006860-a3b8hyyr	3467	11	initiated	initiate	VBN
cord-006860-a3b8hyyr	3467	12	.	.	.
cord-006860-a3b8hyyr	3468	1	As	as	IN
cord-006860-a3b8hyyr	3468	2	no	no	DT
cord-006860-a3b8hyyr	3468	3	improvement	improvement	NN
cord-006860-a3b8hyyr	3468	4	was	be	VBD
cord-006860-a3b8hyyr	3468	5	seen	see	VBN
cord-006860-a3b8hyyr	3468	6	NMR	NMR	NNP
cord-006860-a3b8hyyr	3468	7	was	be	VBD
cord-006860-a3b8hyyr	3468	8	performed	perform	VBN
cord-006860-a3b8hyyr	3468	9	.	.	.
cord-006860-a3b8hyyr	3469	1	This	this	DT
cord-006860-a3b8hyyr	3469	2	revealed	reveal	VBD
cord-006860-a3b8hyyr	3469	3	lesions	lesion	NNS
cord-006860-a3b8hyyr	3469	4	within	within	IN
cord-006860-a3b8hyyr	3469	5	the	the	DT
cord-006860-a3b8hyyr	3469	6	right	right	JJ
cord-006860-a3b8hyyr	3469	7	frontal	frontal	JJ
cord-006860-a3b8hyyr	3469	8	cortex	cortex	NN
cord-006860-a3b8hyyr	3469	9	.	.	.
cord-006860-a3b8hyyr	3470	1	Higher	high	JJR
cord-006860-a3b8hyyr	3470	2	doses	dose	NNS
cord-006860-a3b8hyyr	3470	3	of	of	IN
cord-006860-a3b8hyyr	3470	4	carbamazepine	carbamazepine	NN
cord-006860-a3b8hyyr	3470	5	were	be	VBD
cord-006860-a3b8hyyr	3470	6	not	not	RB
cord-006860-a3b8hyyr	3470	7	succcssfull	succcssfull	VBN
cord-006860-a3b8hyyr	3470	8	as	as	IN
cord-006860-a3b8hyyr	3470	9	was	be	VBD
cord-006860-a3b8hyyr	3470	10	therapy	therapy	NN
cord-006860-a3b8hyyr	3470	11	with	with	IN
cord-006860-a3b8hyyr	3470	12	phenytoin	phenytoin	NNP
cord-006860-a3b8hyyr	3470	13	and	and	CC
cord-006860-a3b8hyyr	3470	14	pfimidone	pfimidone	NNP
cord-006860-a3b8hyyr	3470	15	respectevely	respectevely	NNP
cord-006860-a3b8hyyr	3470	16	.	.	.
cord-006860-a3b8hyyr	3471	1	The	the	DT
cord-006860-a3b8hyyr	3471	2	patient	patient	NN
cord-006860-a3b8hyyr	3471	3	is	be	VBZ
cord-006860-a3b8hyyr	3471	4	now	now	RB
cord-006860-a3b8hyyr	3471	5	treated	treat	VBN
cord-006860-a3b8hyyr	3471	6	with	with	IN
cord-006860-a3b8hyyr	3471	7	carbamazepine	carbamazepine	NN
cord-006860-a3b8hyyr	3471	8	and	and	CC
cord-006860-a3b8hyyr	3471	9	valproate	valproate	RB
cord-006860-a3b8hyyr	3471	10	.	.	.
cord-006860-a3b8hyyr	3472	1	He	-PRON-	PRP
cord-006860-a3b8hyyr	3472	2	still	still	RB
cord-006860-a3b8hyyr	3472	3	suffers	suffer	VBZ
cord-006860-a3b8hyyr	3472	4	from	from	IN
cord-006860-a3b8hyyr	3472	5	one	one	CD
cord-006860-a3b8hyyr	3472	6	short	short	JJ
cord-006860-a3b8hyyr	3472	7	seizure	seizure	NN
cord-006860-a3b8hyyr	3472	8	per	per	IN
cord-006860-a3b8hyyr	3472	9	day	day	NN
cord-006860-a3b8hyyr	3472	10	.	.	.
cord-006860-a3b8hyyr	3473	1	Because	because	IN
cord-006860-a3b8hyyr	3473	2	of	of	IN
cord-006860-a3b8hyyr	3473	3	his	-PRON-	PRP$
cord-006860-a3b8hyyr	3473	4	seizures	seizure	NNS
cord-006860-a3b8hyyr	3473	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	3473	6	started	start	VBD
cord-006860-a3b8hyyr	3473	7	prophylactic	prophylactic	JJ
cord-006860-a3b8hyyr	3473	8	replacement	replacement	NN
cord-006860-a3b8hyyr	3473	9	therapy	therapy	NN
cord-006860-a3b8hyyr	3473	10	with	with	IN
cord-006860-a3b8hyyr	3473	11	600	600	CD
cord-006860-a3b8hyyr	3473	12	I.E.	I.E.	NNP
cord-006860-a3b8hyyr	3473	13	factor	factor	NN
cord-006860-a3b8hyyr	3473	14	IX	IX	NNP
cord-006860-a3b8hyyr	3473	15	twice	twice	RB
cord-006860-a3b8hyyr	3473	16	per	per	IN
cord-006860-a3b8hyyr	3473	17	week	week	NN
cord-006860-a3b8hyyr	3473	18	.	.	.
cord-006860-a3b8hyyr	3474	1	Discussion	discussion	NN
cord-006860-a3b8hyyr	3474	2	:	:	:
cord-006860-a3b8hyyr	3475	1	In	in	IN
cord-006860-a3b8hyyr	3475	2	1992	1992	CD
cord-006860-a3b8hyyr	3475	3	Wilson	Wilson	NNP
cord-006860-a3b8hyyr	3475	4	et	et	NNP
cord-006860-a3b8hyyr	3475	5	al	al	NNP
cord-006860-a3b8hyyr	3475	6	.	.	.
cord-006860-a3b8hyyr	3476	1	first	first	RB
cord-006860-a3b8hyyr	3476	2	detected	detected	JJ
cord-006860-a3b8hyyr	3476	3	brain	brain	NN
cord-006860-a3b8hyyr	3476	4	abnormalities	abnormality	NNS
cord-006860-a3b8hyyr	3476	5	in	in	IN
cord-006860-a3b8hyyr	3476	6	25	25	CD
cord-006860-a3b8hyyr	3476	7	of	of	IN
cord-006860-a3b8hyyr	3476	8	124	124	CD
cord-006860-a3b8hyyr	3476	9	children	child	NNS
cord-006860-a3b8hyyr	3476	10	and	and	CC
cord-006860-a3b8hyyr	3476	11	adolescents	adolescent	NNS
cord-006860-a3b8hyyr	3476	12	with	with	IN
cord-006860-a3b8hyyr	3476	13	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	3476	14	A	A	NNP
cord-006860-a3b8hyyr	3476	15	or	or	CC
cord-006860-a3b8hyyr	3476	16	B	b	NN
cord-006860-a3b8hyyr	3476	17	who	who	WP
cord-006860-a3b8hyyr	3476	18	were	be	VBD
cord-006860-a3b8hyyr	3476	19	negative	negative	JJ
cord-006860-a3b8hyyr	3476	20	for	for	IN
cord-006860-a3b8hyyr	3476	21	immunodeficieney	immunodeficieney	NN
cord-006860-a3b8hyyr	3476	22	virus	virus	NN
cord-006860-a3b8hyyr	3476	23	(	(	-LRB-
cord-006860-a3b8hyyr	3476	24	1	1	CD
cord-006860-a3b8hyyr	3476	25	)	)	-RRB-
cord-006860-a3b8hyyr	3476	26	.	.	.
cord-006860-a3b8hyyr	3477	1	The	the	DT
cord-006860-a3b8hyyr	3477	2	most	most	RBS
cord-006860-a3b8hyyr	3477	3	common	common	JJ
cord-006860-a3b8hyyr	3477	4	findings	finding	NNS
cord-006860-a3b8hyyr	3477	5	(	(	-LRB-
cord-006860-a3b8hyyr	3477	6	14/25	14/25	CD
cord-006860-a3b8hyyr	3477	7	patients	patient	NNS
cord-006860-a3b8hyyr	3477	8	)	)	-RRB-
cord-006860-a3b8hyyr	3477	9	were	be	VBD
cord-006860-a3b8hyyr	3477	10	small	small	JJ
cord-006860-a3b8hyyr	3477	11	,	,	,
cord-006860-a3b8hyyr	3477	12	focal	focal	JJ
cord-006860-a3b8hyyr	3477	13	,	,	,
cord-006860-a3b8hyyr	3477	14	nonhemorrhagic	nonhemorrhagic	JJ
cord-006860-a3b8hyyr	3477	15	white	white	JJ
cord-006860-a3b8hyyr	3477	16	matter	matter	NN
cord-006860-a3b8hyyr	3477	17	lesions	lesion	NNS
cord-006860-a3b8hyyr	3477	18	of	of	IN
cord-006860-a3b8hyyr	3477	19	high	high	JJ
cord-006860-a3b8hyyr	3477	20	signal	signal	NN
cord-006860-a3b8hyyr	3477	21	intensity	intensity	NN
cord-006860-a3b8hyyr	3477	22	on	on	IN
cord-006860-a3b8hyyr	3477	23	T2weighed	t2weighed	JJ
cord-006860-a3b8hyyr	3477	24	images	image	NNS
cord-006860-a3b8hyyr	3477	25	.	.	.
cord-006860-a3b8hyyr	3478	1	Similar	similar	JJ
cord-006860-a3b8hyyr	3478	2	lesions	lesion	NNS
cord-006860-a3b8hyyr	3478	3	have	have	VBP
cord-006860-a3b8hyyr	3478	4	been	be	VBN
cord-006860-a3b8hyyr	3478	5	reported	report	VBN
cord-006860-a3b8hyyr	3478	6	in	in	IN
cord-006860-a3b8hyyr	3478	7	children	child	NNS
cord-006860-a3b8hyyr	3478	8	with	with	IN
cord-006860-a3b8hyyr	3478	9	sickle	sickle	NN
cord-006860-a3b8hyyr	3478	10	cell	cell	NN
cord-006860-a3b8hyyr	3478	11	cerebral	cerebral	NNP
cord-006860-a3b8hyyr	3478	12	infarction	infarction	NNP
cord-006860-a3b8hyyr	3478	13	(	(	-LRB-
cord-006860-a3b8hyyr	3478	14	2	2	CD
cord-006860-a3b8hyyr	3478	15	)	)	-RRB-
cord-006860-a3b8hyyr	3478	16	.	.	.
cord-006860-a3b8hyyr	3479	1	Only	only	RB
cord-006860-a3b8hyyr	3479	2	three	three	CD
cord-006860-a3b8hyyr	3479	3	of	of	IN
cord-006860-a3b8hyyr	3479	4	these	these	DT
cord-006860-a3b8hyyr	3479	5	14	14	CD
cord-006860-a3b8hyyr	3479	6	patients	patient	NNS
cord-006860-a3b8hyyr	3479	7	had	have	VBD
cord-006860-a3b8hyyr	3479	8	seizures	seizure	NNS
cord-006860-a3b8hyyr	3479	9	,	,	,
cord-006860-a3b8hyyr	3479	10	all	all	DT
cord-006860-a3b8hyyr	3479	11	of	of	IN
cord-006860-a3b8hyyr	3479	12	those	those	DT
cord-006860-a3b8hyyr	3479	13	having	have	VBG
cord-006860-a3b8hyyr	3479	14	a	a	DT
cord-006860-a3b8hyyr	3479	15	documented	document	VBN
cord-006860-a3b8hyyr	3479	16	history	history	NN
cord-006860-a3b8hyyr	3479	17	of	of	IN
cord-006860-a3b8hyyr	3479	18	intracranial	intracranial	JJ
cord-006860-a3b8hyyr	3479	19	hemorrhage	hemorrhage	NN
cord-006860-a3b8hyyr	3479	20	.	.	.
cord-006860-a3b8hyyr	3480	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	3480	2	patient	patient	NN
cord-006860-a3b8hyyr	3480	3	has	have	VBZ
cord-006860-a3b8hyyr	3480	4	similar	similar	JJ
cord-006860-a3b8hyyr	3480	5	lesions	lesion	NNS
cord-006860-a3b8hyyr	3480	6	as	as	IN
cord-006860-a3b8hyyr	3480	7	those	those	DT
cord-006860-a3b8hyyr	3480	8	described	describe	VBN
cord-006860-a3b8hyyr	3480	9	by	by	IN
cord-006860-a3b8hyyr	3480	10	Wilson	Wilson	NNP
cord-006860-a3b8hyyr	3480	11	et	et	NNP
cord-006860-a3b8hyyr	3480	12	al	al	NNP
cord-006860-a3b8hyyr	3480	13	.	.	.
cord-006860-a3b8hyyr	3481	1	But	but	CC
cord-006860-a3b8hyyr	3481	2	no	no	DT
cord-006860-a3b8hyyr	3481	3	history	history	NN
cord-006860-a3b8hyyr	3481	4	of	of	IN
cord-006860-a3b8hyyr	3481	5	intracranial	intracranial	JJ
cord-006860-a3b8hyyr	3481	6	hemorrhage	hemorrhage	NN
cord-006860-a3b8hyyr	3481	7	is	be	VBZ
cord-006860-a3b8hyyr	3481	8	documented	document	VBN
cord-006860-a3b8hyyr	3481	9	.	.	.
cord-006860-a3b8hyyr	3482	1	Even	even	RB
cord-006860-a3b8hyyr	3482	2	if	if	IN
cord-006860-a3b8hyyr	3482	3	tuberous	tuberous	JJ
cord-006860-a3b8hyyr	3482	4	sclerosis	sclerosis	NN
cord-006860-a3b8hyyr	3482	5	might	may	MD
cord-006860-a3b8hyyr	3482	6	be	be	VB
cord-006860-a3b8hyyr	3482	7	a	a	DT
cord-006860-a3b8hyyr	3482	8	differential	differential	JJ
cord-006860-a3b8hyyr	3482	9	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	3482	10	,	,	,
cord-006860-a3b8hyyr	3482	11	we	-PRON-	PRP
cord-006860-a3b8hyyr	3482	12	think	think	VBP
cord-006860-a3b8hyyr	3482	13	that	that	IN
cord-006860-a3b8hyyr	3482	14	the	the	DT
cord-006860-a3b8hyyr	3482	15	abnormalities	abnormality	NNS
cord-006860-a3b8hyyr	3482	16	are	be	VBP
cord-006860-a3b8hyyr	3482	17	related	relate	VBN
cord-006860-a3b8hyyr	3482	18	to	to	IN
cord-006860-a3b8hyyr	3482	19	hemophili	hemophili	NNP
cord-006860-a3b8hyyr	3482	20	a	a	DT
cord-006860-a3b8hyyr	3482	21	or	or	CC
cord-006860-a3b8hyyr	3482	22	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3482	23	treatment	treatment	NN
cord-006860-a3b8hyyr	3482	24	,	,	,
cord-006860-a3b8hyyr	3482	25	because	because	IN
cord-006860-a3b8hyyr	3482	26	the	the	DT
cord-006860-a3b8hyyr	3482	27	patient	patient	NN
cord-006860-a3b8hyyr	3482	28	has	have	VBZ
cord-006860-a3b8hyyr	3482	29	no	no	DT
cord-006860-a3b8hyyr	3482	30	further	further	JJ
cord-006860-a3b8hyyr	3482	31	signs	sign	NNS
cord-006860-a3b8hyyr	3482	32	of	of	IN
cord-006860-a3b8hyyr	3482	33	this	this	DT
cord-006860-a3b8hyyr	3482	34	disorder	disorder	NN
cord-006860-a3b8hyyr	3482	35	.	.	.
cord-006860-a3b8hyyr	3483	1	Conclusions	conclusion	NNS
cord-006860-a3b8hyyr	3483	2	:	:	:
cord-006860-a3b8hyyr	3483	3	1	1	CD
cord-006860-a3b8hyyr	3483	4	.	.	.
cord-006860-a3b8hyyr	3484	1	In	in	IN
cord-006860-a3b8hyyr	3484	2	patients	patient	NNS
cord-006860-a3b8hyyr	3484	3	with	with	IN
cord-006860-a3b8hyyr	3484	4	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	3484	5	and	and	CC
cord-006860-a3b8hyyr	3484	6	seizures	seizure	NNS
cord-006860-a3b8hyyr	3484	7	NMR	NMR	NNP
cord-006860-a3b8hyyr	3484	8	might	may	MD
cord-006860-a3b8hyyr	3484	9	be	be	VB
cord-006860-a3b8hyyr	3484	10	useful	useful	JJ
cord-006860-a3b8hyyr	3484	11	as	as	IN
cord-006860-a3b8hyyr	3484	12	a	a	DT
cord-006860-a3b8hyyr	3484	13	high	high	JJ
cord-006860-a3b8hyyr	3484	14	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	3484	15	method	method	NN
cord-006860-a3b8hyyr	3484	16	for	for	IN
cord-006860-a3b8hyyr	3484	17	the	the	DT
cord-006860-a3b8hyyr	3484	18	detection	detection	NN
cord-006860-a3b8hyyr	3484	19	of	of	IN
cord-006860-a3b8hyyr	3484	20	gray	gray	JJ
cord-006860-a3b8hyyr	3484	21	and	and	CC
cord-006860-a3b8hyyr	3484	22	white	white	JJ
cord-006860-a3b8hyyr	3484	23	matter	matter	NN
cord-006860-a3b8hyyr	3484	24	changes	change	NNS
cord-006860-a3b8hyyr	3484	25	.	.	.
cord-006860-a3b8hyyr	3485	1	2	2	LS
cord-006860-a3b8hyyr	3485	2	.	.	.
cord-006860-a3b8hyyr	3486	1	Further	further	JJ
cord-006860-a3b8hyyr	3486	2	studies	study	NNS
cord-006860-a3b8hyyr	3486	3	should	should	MD
cord-006860-a3b8hyyr	3486	4	be	be	VB
cord-006860-a3b8hyyr	3486	5	initiated	initiate	VBN
cord-006860-a3b8hyyr	3486	6	to	to	TO
cord-006860-a3b8hyyr	3486	7	determine	determine	VB
cord-006860-a3b8hyyr	3486	8	the	the	DT
cord-006860-a3b8hyyr	3486	9	prevalence	prevalence	NN
cord-006860-a3b8hyyr	3486	10	of	of	IN
cord-006860-a3b8hyyr	3486	11	pathological	pathological	JJ
cord-006860-a3b8hyyr	3486	12	conditions	condition	NNS
cord-006860-a3b8hyyr	3486	13	in	in	IN
cord-006860-a3b8hyyr	3486	14	the	the	DT
cord-006860-a3b8hyyr	3486	15	brain	brain	NN
cord-006860-a3b8hyyr	3486	16	of	of	IN
cord-006860-a3b8hyyr	3486	17	hemophiliac	hemophiliac	NN
cord-006860-a3b8hyyr	3486	18	patients	patient	NNS
cord-006860-a3b8hyyr	3486	19	.	.	.
cord-006860-a3b8hyyr	3487	1	Disseminated	disseminate	VBN
cord-006860-a3b8hyyr	3487	2	intravascular	intravascular	JJ
cord-006860-a3b8hyyr	3487	3	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3487	4	(	(	-LRB-
cord-006860-a3b8hyyr	3487	5	DIC	DIC	NNP
cord-006860-a3b8hyyr	3487	6	)	)	-RRB-
cord-006860-a3b8hyyr	3487	7	is	be	VBZ
cord-006860-a3b8hyyr	3487	8	a	a	DT
cord-006860-a3b8hyyr	3487	9	rare	rare	JJ
cord-006860-a3b8hyyr	3487	10	,	,	,
cord-006860-a3b8hyyr	3487	11	but	but	CC
cord-006860-a3b8hyyr	3487	12	foudroyant	foudroyant	JJ
cord-006860-a3b8hyyr	3487	13	disease	disease	NN
cord-006860-a3b8hyyr	3487	14	occuring	occur	VBG
cord-006860-a3b8hyyr	3487	15	in	in	IN
cord-006860-a3b8hyyr	3487	16	GRAM	gram	NN
cord-006860-a3b8hyyr	3487	17	-	-	HYPH
cord-006860-a3b8hyyr	3487	18	negative	negative	JJ
cord-006860-a3b8hyyr	3487	19	sepsis	sepsis	NN
cord-006860-a3b8hyyr	3487	20	like	like	IN
cord-006860-a3b8hyyr	3487	21	meningococcal	meningococcal	JJ
cord-006860-a3b8hyyr	3487	22	septicemia	septicemia	NN
cord-006860-a3b8hyyr	3487	23	.	.	.
cord-006860-a3b8hyyr	3488	1	Despite	despite	IN
cord-006860-a3b8hyyr	3488	2	the	the	DT
cord-006860-a3b8hyyr	3488	3	avallibility	avallibility	NN
cord-006860-a3b8hyyr	3488	4	of	of	IN
cord-006860-a3b8hyyr	3488	5	potent	potent	JJ
cord-006860-a3b8hyyr	3488	6	antibiotics	antibiotic	NNS
cord-006860-a3b8hyyr	3488	7	,	,	,
cord-006860-a3b8hyyr	3488	8	mortality	mortality	NN
cord-006860-a3b8hyyr	3488	9	in	in	IN
cord-006860-a3b8hyyr	3488	10	mertingococcal	mertingococcal	JJ
cord-006860-a3b8hyyr	3488	11	disease	disease	NN
cord-006860-a3b8hyyr	3488	12	remains	remain	VBZ
cord-006860-a3b8hyyr	3488	13	high	high	JJ
cord-006860-a3b8hyyr	3488	14	(	(	-LRB-
cord-006860-a3b8hyyr	3488	15	about	about	RB
cord-006860-a3b8hyyr	3488	16	10	10	CD
cord-006860-a3b8hyyr	3488	17	%	%	NN
cord-006860-a3b8hyyr	3488	18	)	)	-RRB-
cord-006860-a3b8hyyr	3488	19	,	,	,
cord-006860-a3b8hyyr	3488	20	rising	rise	VBG
cord-006860-a3b8hyyr	3488	21	to	to	IN
cord-006860-a3b8hyyr	3488	22	40	40	CD
cord-006860-a3b8hyyr	3488	23	%	%	NN
cord-006860-a3b8hyyr	3488	24	in	in	IN
cord-006860-a3b8hyyr	3488	25	patients	patient	NNS
cord-006860-a3b8hyyr	3488	26	presenting	present	VBG
cord-006860-a3b8hyyr	3488	27	with	with	IN
cord-006860-a3b8hyyr	3488	28	severe	severe	JJ
cord-006860-a3b8hyyr	3488	29	shock	shock	NN
cord-006860-a3b8hyyr	3488	30	and	and	CC
cord-006860-a3b8hyyr	3488	31	consecutive	consecutive	JJ
cord-006860-a3b8hyyr	3488	32	DIC	DIC	NNP
cord-006860-a3b8hyyr	3488	33	.	.	.
cord-006860-a3b8hyyr	3489	1	As	as	IN
cord-006860-a3b8hyyr	3489	2	the	the	DT
cord-006860-a3b8hyyr	3489	3	clinical	clinical	JJ
cord-006860-a3b8hyyr	3489	4	course	course	NN
cord-006860-a3b8hyyr	3489	5	and	and	CC
cord-006860-a3b8hyyr	3489	6	the	the	DT
cord-006860-a3b8hyyr	3489	7	severity	severity	NN
cord-006860-a3b8hyyr	3489	8	of	of	IN
cord-006860-a3b8hyyr	3489	9	manifestations	manifestation	NNS
cord-006860-a3b8hyyr	3489	10	of	of	IN
cord-006860-a3b8hyyr	3489	11	systemic	systemic	JJ
cord-006860-a3b8hyyr	3489	12	meningococcal	meningococcal	JJ
cord-006860-a3b8hyyr	3489	13	infections	infection	NNS
cord-006860-a3b8hyyr	3489	14	varies	vary	VBZ
cord-006860-a3b8hyyr	3489	15	there	there	EX
cord-006860-a3b8hyyr	3489	16	is	be	VBZ
cord-006860-a3b8hyyr	3489	17	a	a	DT
cord-006860-a3b8hyyr	3489	18	need	need	NN
cord-006860-a3b8hyyr	3489	19	for	for	IN
cord-006860-a3b8hyyr	3489	20	early	early	JJ
cord-006860-a3b8hyyr	3489	21	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	3489	22	of	of	IN
cord-006860-a3b8hyyr	3489	23	the	the	DT
cord-006860-a3b8hyyr	3489	24	infection	infection	NN
cord-006860-a3b8hyyr	3489	25	and	and	CC
cord-006860-a3b8hyyr	3489	26	stage	stage	NN
cord-006860-a3b8hyyr	3489	27	of	of	IN
cord-006860-a3b8hyyr	3489	28	coagulopathy	coagulopathy	NN
cord-006860-a3b8hyyr	3489	29	in	in	IN
cord-006860-a3b8hyyr	3489	30	order	order	NN
cord-006860-a3b8hyyr	3489	31	to	to	TO
cord-006860-a3b8hyyr	3489	32	reduce	reduce	VB
cord-006860-a3b8hyyr	3489	33	the	the	DT
cord-006860-a3b8hyyr	3489	34	high	high	JJ
cord-006860-a3b8hyyr	3489	35	mortality	mortality	NN
cord-006860-a3b8hyyr	3489	36	rate	rate	NN
cord-006860-a3b8hyyr	3489	37	.	.	.
cord-006860-a3b8hyyr	3490	1	Few	few	JJ
cord-006860-a3b8hyyr	3490	2	and	and	CC
cord-006860-a3b8hyyr	3490	3	rapidly	rapidly	RB
cord-006860-a3b8hyyr	3490	4	available	available	JJ
cord-006860-a3b8hyyr	3490	5	parameters	parameter	NNS
cord-006860-a3b8hyyr	3490	6	are	be	VBP
cord-006860-a3b8hyyr	3490	7	needed	need	VBN
cord-006860-a3b8hyyr	3490	8	to	to	TO
cord-006860-a3b8hyyr	3490	9	classify	classify	VB
cord-006860-a3b8hyyr	3490	10	the	the	DT
cord-006860-a3b8hyyr	3490	11	wide	wide	JJ
cord-006860-a3b8hyyr	3490	12	spectrum	spectrum	NN
cord-006860-a3b8hyyr	3490	13	of	of	IN
cord-006860-a3b8hyyr	3490	14	clinical	clinical	JJ
cord-006860-a3b8hyyr	3490	15	and	and	CC
cord-006860-a3b8hyyr	3490	16	laboratory	laboratory	NN
cord-006860-a3b8hyyr	3490	17	findings	finding	NNS
cord-006860-a3b8hyyr	3490	18	in	in	IN
cord-006860-a3b8hyyr	3490	19	patients	patient	NNS
cord-006860-a3b8hyyr	3490	20	with	with	IN
cord-006860-a3b8hyyr	3490	21	DIC	DIC	NNP
cord-006860-a3b8hyyr	3490	22	.	.	.
cord-006860-a3b8hyyr	3491	1	The	the	DT
cord-006860-a3b8hyyr	3491	2	parameters	parameter	NNS
cord-006860-a3b8hyyr	3491	3	include	include	VBP
cord-006860-a3b8hyyr	3491	4	partial	partial	JJ
cord-006860-a3b8hyyr	3491	5	thmmboplastin	thmmboplastin	NNP
cord-006860-a3b8hyyr	3491	6	time	time	NN
cord-006860-a3b8hyyr	3491	7	,	,	,
cord-006860-a3b8hyyr	3491	8	pmthmmbin	pmthmmbin	NNP
cord-006860-a3b8hyyr	3491	9	time	time	NN
cord-006860-a3b8hyyr	3491	10	,	,	,
cord-006860-a3b8hyyr	3491	11	plasma	plasma	NN
cord-006860-a3b8hyyr	3491	12	levels	level	NNS
cord-006860-a3b8hyyr	3491	13	of	of	IN
cord-006860-a3b8hyyr	3491	14	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3491	15	,	,	,
cord-006860-a3b8hyyr	3491	16	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3491	17	monomers	monomer	NNS
cord-006860-a3b8hyyr	3491	18	and	and	CC
cord-006860-a3b8hyyr	3491	19	dimers	dimer	NNS
cord-006860-a3b8hyyr	3491	20	,	,	,
cord-006860-a3b8hyyr	3491	21	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3491	22	degradation	degradation	NN
cord-006860-a3b8hyyr	3491	23	products	product	NNS
cord-006860-a3b8hyyr	3491	24	and	and	CC
cord-006860-a3b8hyyr	3491	25	the	the	DT
cord-006860-a3b8hyyr	3491	26	thrombocyte	thrombocyte	NNP
cord-006860-a3b8hyyr	3491	27	count	count	NN
cord-006860-a3b8hyyr	3491	28	.	.	.
cord-006860-a3b8hyyr	3492	1	Monitoring	monitor	VBG
cord-006860-a3b8hyyr	3492	2	the	the	DT
cord-006860-a3b8hyyr	3492	3	course	course	NN
cord-006860-a3b8hyyr	3492	4	of	of	IN
cord-006860-a3b8hyyr	3492	5	hemostaseologicai	hemostaseologicai	NNP
cord-006860-a3b8hyyr	3492	6	findings	finding	NNS
cord-006860-a3b8hyyr	3492	7	in	in	IN
cord-006860-a3b8hyyr	3492	8	26	26	CD
cord-006860-a3b8hyyr	3492	9	pediatric	pediatric	JJ
cord-006860-a3b8hyyr	3492	10	patients	patient	NNS
cord-006860-a3b8hyyr	3492	11	with	with	IN
cord-006860-a3b8hyyr	3492	12	systemic	systemic	JJ
cord-006860-a3b8hyyr	3492	13	meningococeal	meningococeal	JJ
cord-006860-a3b8hyyr	3492	14	infections	infection	NNS
cord-006860-a3b8hyyr	3492	15	we	-PRON-	PRP
cord-006860-a3b8hyyr	3492	16	observed	observe	VBD
cord-006860-a3b8hyyr	3492	17	a	a	DT
cord-006860-a3b8hyyr	3492	18	change	change	NN
cord-006860-a3b8hyyr	3492	19	of	of	IN
cord-006860-a3b8hyyr	3492	20	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3492	21	parameters	parameter	NNS
cord-006860-a3b8hyyr	3492	22	as	as	RB
cord-006860-a3b8hyyr	3492	23	early	early	RB
cord-006860-a3b8hyyr	3492	24	as	as	IN
cord-006860-a3b8hyyr	3492	25	in	in	IN
cord-006860-a3b8hyyr	3492	26	the	the	DT
cord-006860-a3b8hyyr	3492	27	first	first	JJ
cord-006860-a3b8hyyr	3492	28	stages	stage	NNS
cord-006860-a3b8hyyr	3492	29	of	of	IN
cord-006860-a3b8hyyr	3492	30	the	the	DT
cord-006860-a3b8hyyr	3492	31	infection	infection	NN
cord-006860-a3b8hyyr	3492	32	:	:	:
cord-006860-a3b8hyyr	3492	33	A	a	DT
cord-006860-a3b8hyyr	3492	34	prolongation	prolongation	NN
cord-006860-a3b8hyyr	3492	35	of	of	IN
cord-006860-a3b8hyyr	3492	36	partial	partial	JJ
cord-006860-a3b8hyyr	3492	37	thromboplastin	thromboplastin	NN
cord-006860-a3b8hyyr	3492	38	time	time	NN
cord-006860-a3b8hyyr	3492	39	to	to	IN
cord-006860-a3b8hyyr	3492	40	an	an	DT
cord-006860-a3b8hyyr	3492	41	average	average	NN
cord-006860-a3b8hyyr	3492	42	of	of	IN
cord-006860-a3b8hyyr	3492	43	69	69	CD
cord-006860-a3b8hyyr	3492	44	.	.	.
cord-006860-a3b8hyyr	3493	1	1	1	CD
cord-006860-a3b8hyyr	3493	2	sec	sec	NNP
cord-006860-a3b8hyyr	3493	3	(	(	-LRB-
cord-006860-a3b8hyyr	3493	4	range	range	NNP
cord-006860-a3b8hyyr	3493	5	22	22	CD
cord-006860-a3b8hyyr	3493	6	-150	-150	NN
cord-006860-a3b8hyyr	3493	7	sec	sec	NNP
cord-006860-a3b8hyyr	3493	8	,	,	,
cord-006860-a3b8hyyr	3493	9	norreal	norreal	JJ
cord-006860-a3b8hyyr	3493	10	30	30	CD
cord-006860-a3b8hyyr	3493	11	-45	-45	NNP
cord-006860-a3b8hyyr	3493	12	sec	sec	NNP
cord-006860-a3b8hyyr	3493	13	)	)	-RRB-
cord-006860-a3b8hyyr	3493	14	,	,	,
cord-006860-a3b8hyyr	3493	15	a	a	DT
cord-006860-a3b8hyyr	3493	16	decrease	decrease	NN
cord-006860-a3b8hyyr	3493	17	of	of	IN
cord-006860-a3b8hyyr	3493	18	prothrombin	prothrombin	JJ
cord-006860-a3b8hyyr	3493	19	time	time	NN
cord-006860-a3b8hyyr	3493	20	to	to	IN
cord-006860-a3b8hyyr	3493	21	45.7	45.7	CD
cord-006860-a3b8hyyr	3493	22	%	%	NN
cord-006860-a3b8hyyr	3493	23	(	(	-LRB-
cord-006860-a3b8hyyr	3493	24	range	range	NN
cord-006860-a3b8hyyr	3493	25	13	13	CD
cord-006860-a3b8hyyr	3493	26	-71	-71	CD
cord-006860-a3b8hyyr	3493	27	%	%	NN
cord-006860-a3b8hyyr	3493	28	,	,	,
cord-006860-a3b8hyyr	3493	29	normal	normal	JJ
cord-006860-a3b8hyyr	3493	30	70	70	CD
cord-006860-a3b8hyyr	3493	31	-100	-100	NN
cord-006860-a3b8hyyr	3493	32	%	%	NN
cord-006860-a3b8hyyr	3493	33	)	)	-RRB-
cord-006860-a3b8hyyr	3493	34	and	and	CC
cord-006860-a3b8hyyr	3493	35	of	of	IN
cord-006860-a3b8hyyr	3493	36	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3493	37	III	III	NNP
cord-006860-a3b8hyyr	3493	38	to	to	IN
cord-006860-a3b8hyyr	3493	39	an	an	DT
cord-006860-a3b8hyyr	3493	40	average	average	JJ
cord-006860-a3b8hyyr	3493	41	level	level	NN
cord-006860-a3b8hyyr	3493	42	of	of	IN
cord-006860-a3b8hyyr	3493	43	16	16	CD
cord-006860-a3b8hyyr	3493	44	.	.	.
cord-006860-a3b8hyyr	3494	1	8	8	CD
cord-006860-a3b8hyyr	3494	2	U	u	NN
cord-006860-a3b8hyyr	3494	3	/	/	SYM
cord-006860-a3b8hyyr	3494	4	ml	ml	NN
cord-006860-a3b8hyyr	3494	5	(	(	-LRB-
cord-006860-a3b8hyyr	3494	6	normal	normal	JJ
cord-006860-a3b8hyyr	3494	7	20	20	CD
cord-006860-a3b8hyyr	3494	8	-29	-29	CD
cord-006860-a3b8hyyr	3494	9	U	U	NNP
cord-006860-a3b8hyyr	3494	10	/	/	SYM
cord-006860-a3b8hyyr	3494	11	ml	ml	NN
cord-006860-a3b8hyyr	3494	12	)	)	-RRB-
cord-006860-a3b8hyyr	3494	13	was	be	VBD
cord-006860-a3b8hyyr	3494	14	found	find	VBN
cord-006860-a3b8hyyr	3494	15	1	1	CD
cord-006860-a3b8hyyr	3494	16	to	to	IN
cord-006860-a3b8hyyr	3494	17	4	4	CD
cord-006860-a3b8hyyr	3494	18	(	(	-LRB-
cord-006860-a3b8hyyr	3494	19	-6	-6	NNP
cord-006860-a3b8hyyr	3494	20	)	)	-RRB-
cord-006860-a3b8hyyr	3494	21	hours	hour	NNS
cord-006860-a3b8hyyr	3494	22	after	after	IN
cord-006860-a3b8hyyr	3494	23	admission	admission	NN
cord-006860-a3b8hyyr	3494	24	.	.	.
cord-006860-a3b8hyyr	3495	1	The	the	DT
cord-006860-a3b8hyyr	3495	2	consecutive	consecutive	JJ
cord-006860-a3b8hyyr	3495	3	development	development	NN
cord-006860-a3b8hyyr	3495	4	of	of	IN
cord-006860-a3b8hyyr	3495	5	hemostaseological	hemostaseological	JJ
cord-006860-a3b8hyyr	3495	6	parameters	parameter	NNS
cord-006860-a3b8hyyr	3495	7	mentioned	mention	VBN
cord-006860-a3b8hyyr	3495	8	above	above	RB
cord-006860-a3b8hyyr	3495	9	permitted	permit	VBD
cord-006860-a3b8hyyr	3495	10	to	to	TO
cord-006860-a3b8hyyr	3495	11	define	define	VB
cord-006860-a3b8hyyr	3495	12	the	the	DT
cord-006860-a3b8hyyr	3495	13	stage	stage	NN
cord-006860-a3b8hyyr	3495	14	of	of	IN
cord-006860-a3b8hyyr	3495	15	coagulopathy	coagulopathy	NN
cord-006860-a3b8hyyr	3495	16	and	and	CC
cord-006860-a3b8hyyr	3495	17	thus	thus	RB
cord-006860-a3b8hyyr	3495	18	to	to	TO
cord-006860-a3b8hyyr	3495	19	induce	induce	VB
cord-006860-a3b8hyyr	3495	20	a	a	DT
cord-006860-a3b8hyyr	3495	21	stage	stage	NN
cord-006860-a3b8hyyr	3495	22	related	relate	VBN
cord-006860-a3b8hyyr	3495	23	therapy	therapy	NN
cord-006860-a3b8hyyr	3495	24	.	.	.
cord-006860-a3b8hyyr	3496	1	Primary	primary	JJ
cord-006860-a3b8hyyr	3496	2	treatment	treatment	NN
cord-006860-a3b8hyyr	3496	3	consisted	consist	VBD
cord-006860-a3b8hyyr	3496	4	in	in	IN
cord-006860-a3b8hyyr	3496	5	control	control	NN
cord-006860-a3b8hyyr	3496	6	of	of	IN
cord-006860-a3b8hyyr	3496	7	shock	shock	NN
cord-006860-a3b8hyyr	3496	8	by	by	IN
cord-006860-a3b8hyyr	3496	9	liquid	liquid	JJ
cord-006860-a3b8hyyr	3496	10	substitution	substitution	NN
cord-006860-a3b8hyyr	3496	11	,	,	,
cord-006860-a3b8hyyr	3496	12	compensation	compensation	NN
cord-006860-a3b8hyyr	3496	13	of	of	IN
cord-006860-a3b8hyyr	3496	14	metabolic	metabolic	JJ
cord-006860-a3b8hyyr	3496	15	acidosis	acidosis	NN
cord-006860-a3b8hyyr	3496	16	,	,	,
cord-006860-a3b8hyyr	3496	17	correction	correction	NN
cord-006860-a3b8hyyr	3496	18	of	of	IN
cord-006860-a3b8hyyr	3496	19	clotting	clotting	NN
cord-006860-a3b8hyyr	3496	20	disorders	disorder	NNS
cord-006860-a3b8hyyr	3496	21	(	(	-LRB-
cord-006860-a3b8hyyr	3496	22	AT	at	IN
cord-006860-a3b8hyyr	3496	23	III	III	NNP
cord-006860-a3b8hyyr	3496	24	and	and	CC
cord-006860-a3b8hyyr	3496	25	heparin	heparin	NN
cord-006860-a3b8hyyr	3496	26	in	in	IN
cord-006860-a3b8hyyr	3496	27	stage	stage	NN
cord-006860-a3b8hyyr	3496	28	of	of	IN
cord-006860-a3b8hyyr	3496	29	pre	pre	JJ
cord-006860-a3b8hyyr	3496	30	-	-	JJ
cord-006860-a3b8hyyr	3496	31	DIC	dic	JJ
cord-006860-a3b8hyyr	3496	32	;	;	:
cord-006860-a3b8hyyr	3496	33	AT	at	IN
cord-006860-a3b8hyyr	3496	34	III	iii	CD
cord-006860-a3b8hyyr	3496	35	and	and	CC
cord-006860-a3b8hyyr	3496	36	fresh	fresh	JJ
cord-006860-a3b8hyyr	3496	37	frozen	frozen	JJ
cord-006860-a3b8hyyr	3496	38	plasma	plasma	NN
cord-006860-a3b8hyyr	3496	39	in	in	IN
cord-006860-a3b8hyyr	3496	40	case	case	NN
cord-006860-a3b8hyyr	3496	41	of	of	IN
cord-006860-a3b8hyyr	3496	42	advanced	advanced	JJ
cord-006860-a3b8hyyr	3496	43	DIC	DIC	NNP
cord-006860-a3b8hyyr	3496	44	)	)	-RRB-
cord-006860-a3b8hyyr	3496	45	and	and	CC
cord-006860-a3b8hyyr	3496	46	treatment	treatment	NN
cord-006860-a3b8hyyr	3496	47	with	with	IN
cord-006860-a3b8hyyr	3496	48	g	g	NN
cord-006860-a3b8hyyr	3496	49	-	-	HYPH
cord-006860-a3b8hyyr	3496	50	lactam	lactam	NNP
cord-006860-a3b8hyyr	3496	51	antibiotics	antibiotic	NNS
cord-006860-a3b8hyyr	3496	52	(	(	-LRB-
cord-006860-a3b8hyyr	3496	53	e.	e.	NNP
cord-006860-a3b8hyyr	3496	54	g.	g.	NNP
cord-006860-a3b8hyyr	3496	55	cefotaxime	cefotaxime	NNP
cord-006860-a3b8hyyr	3496	56	or	or	CC
cord-006860-a3b8hyyr	3496	57	ceftriaxone	ceftriaxone	NN
cord-006860-a3b8hyyr	3496	58	)	)	-RRB-
cord-006860-a3b8hyyr	3496	59	.	.	.
cord-006860-a3b8hyyr	3497	1	An	an	DT
cord-006860-a3b8hyyr	3497	2	early	early	JJ
cord-006860-a3b8hyyr	3497	3	assessment	assessment	NN
cord-006860-a3b8hyyr	3497	4	of	of	IN
cord-006860-a3b8hyyr	3497	5	the	the	DT
cord-006860-a3b8hyyr	3497	6	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3497	7	disorders	disorder	NNS
cord-006860-a3b8hyyr	3497	8	in	in	IN
cord-006860-a3b8hyyr	3497	9	meningococcal	meningococcal	JJ
cord-006860-a3b8hyyr	3497	10	disease	disease	NN
cord-006860-a3b8hyyr	3497	11	can	can	MD
cord-006860-a3b8hyyr	3497	12	be	be	VB
cord-006860-a3b8hyyr	3497	13	based	base	VBN
cord-006860-a3b8hyyr	3497	14	on	on	IN
cord-006860-a3b8hyyr	3497	15	few	few	JJ
cord-006860-a3b8hyyr	3497	16	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3497	17	parameters	parameter	NNS
cord-006860-a3b8hyyr	3497	18	,	,	,
cord-006860-a3b8hyyr	3497	19	thus	thus	RB
cord-006860-a3b8hyyr	3497	20	an	an	DT
cord-006860-a3b8hyyr	3497	21	appropriate	appropriate	JJ
cord-006860-a3b8hyyr	3497	22	treatment	treatment	NN
cord-006860-a3b8hyyr	3497	23	may	may	MD
cord-006860-a3b8hyyr	3497	24	be	be	VB
cord-006860-a3b8hyyr	3497	25	arranged	arrange	VBN
cord-006860-a3b8hyyr	3497	26	to	to	TO
cord-006860-a3b8hyyr	3497	27	prevenl	prevenl	VB
cord-006860-a3b8hyyr	3497	28	the	the	DT
cord-006860-a3b8hyyr	3497	29	patient	patient	NN
cord-006860-a3b8hyyr	3497	30	from	from	IN
cord-006860-a3b8hyyr	3497	31	a	a	DT
cord-006860-a3b8hyyr	3497	32	fatal	fatal	JJ
cord-006860-a3b8hyyr	3497	33	outcome	outcome	NN
cord-006860-a3b8hyyr	3497	34	of	of	IN
cord-006860-a3b8hyyr	3497	35	meningococcai	meningococcai	FW
cord-006860-a3b8hyyr	3497	36	septicemia	septicemia	NN
cord-006860-a3b8hyyr	3497	37	and	and	CC
cord-006860-a3b8hyyr	3497	38	protect	protect	VB
cord-006860-a3b8hyyr	3497	39	him	-PRON-	PRP
cord-006860-a3b8hyyr	3497	40	from	from	IN
cord-006860-a3b8hyyr	3497	41	the	the	DT
cord-006860-a3b8hyyr	3497	42	development	development	NN
cord-006860-a3b8hyyr	3497	43	of	of	IN
cord-006860-a3b8hyyr	3497	44	a	a	DT
cord-006860-a3b8hyyr	3497	45	WATERHOUSE	WATERHOUSE	NNP
cord-006860-a3b8hyyr	3497	46	-	-	HYPH
cord-006860-a3b8hyyr	3497	47	FRIDERICHSEN	FRIDERICHSEN	NNP
cord-006860-a3b8hyyr	3497	48	-	-	HYPH
cord-006860-a3b8hyyr	3497	49	syndrome	syndrome	NN
cord-006860-a3b8hyyr	3497	50	.	.	.
cord-006860-a3b8hyyr	3498	1	This	this	DT
cord-006860-a3b8hyyr	3498	2	study	study	NN
cord-006860-a3b8hyyr	3498	3	was	be	VBD
cord-006860-a3b8hyyr	3498	4	designed	design	VBN
cord-006860-a3b8hyyr	3498	5	to	to	IN
cord-006860-a3b8hyyr	3498	6	prospectivdy	prospectivdy	NNS
cord-006860-a3b8hyyr	3498	7	evaluate	evaluate	VB
cord-006860-a3b8hyyr	3498	8	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3498	9	and	and	CC
cord-006860-a3b8hyyr	3498	10	flbrinolyfie	flbrinolyfie	NN
cord-006860-a3b8hyyr	3498	11	activation	activation	NN
cord-006860-a3b8hyyr	3498	12	in	in	IN
cord-006860-a3b8hyyr	3498	13	60	60	CD
cord-006860-a3b8hyyr	3498	14	children	child	NNS
cord-006860-a3b8hyyr	3498	15	(	(	-LRB-
cord-006860-a3b8hyyr	3498	16	neonate	neonate	NN
cord-006860-a3b8hyyr	3498	17	-16	-16	CD
cord-006860-a3b8hyyr	3498	18	years	year	NNS
cord-006860-a3b8hyyr	3498	19	)	)	-RRB-
cord-006860-a3b8hyyr	3498	20	during	during	IN
cord-006860-a3b8hyyr	3498	21	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	3498	22	catheterisation	catheterisation	NN
cord-006860-a3b8hyyr	3498	23	with	with	IN
cord-006860-a3b8hyyr	3498	24	low	low	JJ
cord-006860-a3b8hyyr	3498	25	dose	dose	NN
cord-006860-a3b8hyyr	3498	26	flush	flush	JJ
cord-006860-a3b8hyyr	3498	27	heparin	heparin	NN
cord-006860-a3b8hyyr	3499	1	(	(	-LRB-
cord-006860-a3b8hyyr	3499	2	10	10	CD
cord-006860-a3b8hyyr	3499	3	IU	IU	NNP
cord-006860-a3b8hyyr	3499	4	/	/	SYM
cord-006860-a3b8hyyr	3499	5	ml	ml	NN
cord-006860-a3b8hyyr	3499	6	saline	saline	NN
cord-006860-a3b8hyyr	3499	7	)	)	-RRB-
cord-006860-a3b8hyyr	3499	8	.	.	.
cord-006860-a3b8hyyr	3500	1	APTT	APTT	NNP
cord-006860-a3b8hyyr	3500	2	(	(	-LRB-
cord-006860-a3b8hyyr	3500	3	Instrumentation	Instrumentation	NNP
cord-006860-a3b8hyyr	3500	4	Laboratory	Laboratory	NNP
cord-006860-a3b8hyyr	3500	5	:	:	:
cord-006860-a3b8hyyr	3500	6	see	see	VB
cord-006860-a3b8hyyr	3500	7	)	)	-RRB-
cord-006860-a3b8hyyr	3500	8	,	,	,
cord-006860-a3b8hyyr	3500	9	anti	anti	NNP
cord-006860-a3b8hyyr	3500	10	Xa	Xa	NNP
cord-006860-a3b8hyyr	3500	11	activity	activity	NN
cord-006860-a3b8hyyr	3500	12	(	(	-LRB-
cord-006860-a3b8hyyr	3500	13	Xa	Xa	NNP
cord-006860-a3b8hyyr	3500	14	;	;	:
cord-006860-a3b8hyyr	3500	15	Chromogenix	Chromogenix	NNP
cord-006860-a3b8hyyr	3500	16	:	:	:
cord-006860-a3b8hyyr	3500	17	IU	IU	NNP
cord-006860-a3b8hyyr	3500	18	/	/	SYM
cord-006860-a3b8hyyr	3500	19	ml	ml	NNP
cord-006860-a3b8hyyr	3500	20	)	)	-RRB-
cord-006860-a3b8hyyr	3500	21	,	,	,
cord-006860-a3b8hyyr	3500	22	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3500	23	fragment	fragment	NN
cord-006860-a3b8hyyr	3501	1	Ft.2	ft.2	RB
cord-006860-a3b8hyyr	3502	1	(	(	-LRB-
cord-006860-a3b8hyyr	3502	2	F1.2	F1.2	NNP
cord-006860-a3b8hyyr	3502	3	;	;	:
cord-006860-a3b8hyyr	3502	4	Behring	Behring	NNP
cord-006860-a3b8hyyr	3502	5	Werkc	Werkc	NNP
cord-006860-a3b8hyyr	3502	6	Marburg	Marburg	NNP
cord-006860-a3b8hyyr	3502	7	:	:	:
cord-006860-a3b8hyyr	3503	1	nmol	nmol	NNP
cord-006860-a3b8hyyr	3503	2	/	/	SYM
cord-006860-a3b8hyyr	3503	3	l	l	NNP
cord-006860-a3b8hyyr	3503	4	)	)	-RRB-
cord-006860-a3b8hyyr	3503	5	and	and	CC
cord-006860-a3b8hyyr	3503	6	D	D	NNP
cord-006860-a3b8hyyr	3503	7	-Dimer	-Dimer	NNP
cord-006860-a3b8hyyr	3503	8	formation	formation	NN
cord-006860-a3b8hyyr	3503	9	(	(	-LRB-
cord-006860-a3b8hyyr	3503	10	D	D	NNP
cord-006860-a3b8hyyr	3503	11	-	-	HYPH
cord-006860-a3b8hyyr	3503	12	D	d	JJ
cord-006860-a3b8hyyr	3503	13	;	;	:
cord-006860-a3b8hyyr	3504	1	Bnhring	Bnhring	NNP
cord-006860-a3b8hyyr	3504	2	Werke	Werke	NNP
cord-006860-a3b8hyyr	3504	3	/	/	SYM
cord-006860-a3b8hyyr	3504	4	vhrburg	vhrburg	NN
cord-006860-a3b8hyyr	3504	5	:	:	:
cord-006860-a3b8hyyr	3505	1	ug	ug	NNP
cord-006860-a3b8hyyr	3505	2	/	/	SYM
cord-006860-a3b8hyyr	3505	3	l	l	NNP
cord-006860-a3b8hyyr	3505	4	)	)	-RRB-
cord-006860-a3b8hyyr	3505	5	were	be	VBD
cord-006860-a3b8hyyr	3505	6	investigated	investigate	VBN
cord-006860-a3b8hyyr	3505	7	before	before	IN
cord-006860-a3b8hyyr	3505	8	(	(	-LRB-
cord-006860-a3b8hyyr	3505	9	T1	T1	NNP
cord-006860-a3b8hyyr	3505	10	)	)	-RRB-
cord-006860-a3b8hyyr	3505	11	,	,	,
cord-006860-a3b8hyyr	3505	12	at	at	IN
cord-006860-a3b8hyyr	3505	13	the	the	DT
cord-006860-a3b8hyyr	3505	14	end	end	NN
cord-006860-a3b8hyyr	3505	15	(	(	-LRB-
cord-006860-a3b8hyyr	3505	16	T2	T2	NNP
cord-006860-a3b8hyyr	3505	17	)	)	-RRB-
cord-006860-a3b8hyyr	3505	18	and	and	CC
cord-006860-a3b8hyyr	3505	19	24	24	CD
cord-006860-a3b8hyyr	3505	20	h	h	NN
cord-006860-a3b8hyyr	3505	21	after	after	IN
cord-006860-a3b8hyyr	3505	22	cardiac	cardiac	NNP
cord-006860-a3b8hyyr	3505	23	catheterisation	catheterisation	NNP
cord-006860-a3b8hyyr	3505	24	(	(	-LRB-
cord-006860-a3b8hyyr	3505	25	T3	T3	NNP
cord-006860-a3b8hyyr	3505	26	)	)	-RRB-
cord-006860-a3b8hyyr	3505	27	.	.	.
cord-006860-a3b8hyyr	3506	1	In	in	IN
cord-006860-a3b8hyyr	3506	2	addition	addition	NN
cord-006860-a3b8hyyr	3506	3	,	,	,
cord-006860-a3b8hyyr	3506	4	to	to	TO
cord-006860-a3b8hyyr	3506	5	evaluate	evaluate	VB
cord-006860-a3b8hyyr	3506	6	the	the	DT
cord-006860-a3b8hyyr	3506	7	influence	influence	NN
cord-006860-a3b8hyyr	3506	8	of	of	IN
cord-006860-a3b8hyyr	3506	9	inherited	inherit	VBN
cord-006860-a3b8hyyr	3506	10	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	3506	11	in	in	IN
cord-006860-a3b8hyyr	3506	12	all	all	DT
cord-006860-a3b8hyyr	3506	13	patients	patient	NNS
cord-006860-a3b8hyyr	3506	14	resistance	resistance	NN
cord-006860-a3b8hyyr	3506	15	to	to	IN
cord-006860-a3b8hyyr	3506	16	activated	activate	VBN
cord-006860-a3b8hyyr	3506	17	protein	protein	NN
cord-006860-a3b8hyyr	3506	18	C	c	NN
cord-006860-a3b8hyyr	3506	19	(	(	-LRB-
cord-006860-a3b8hyyr	3506	20	APCR	APCR	NNP
cord-006860-a3b8hyyr	3506	21	)	)	-RRB-
cord-006860-a3b8hyyr	3506	22	,	,	,
cord-006860-a3b8hyyr	3506	23	protein	protein	NN
cord-006860-a3b8hyyr	3506	24	C	C	NNP
cord-006860-a3b8hyyr	3506	25	,	,	,
cord-006860-a3b8hyyr	3506	26	protein	protein	NN
cord-006860-a3b8hyyr	3506	27	S	S	NNP
cord-006860-a3b8hyyr	3506	28	and	and	CC
cord-006860-a3b8hyyr	3506	29	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3506	30	were	be	VBD
cord-006860-a3b8hyyr	3506	31	investigated	investigate	VBN
cord-006860-a3b8hyyr	3506	32	.	.	.
cord-006860-a3b8hyyr	3507	1	During	during	IN
cord-006860-a3b8hyyr	3507	2	catheterisation	catheterisation	NN
cord-006860-a3b8hyyr	3507	3	median	median	NN
cord-006860-a3b8hyyr	3507	4	(	(	-LRB-
cord-006860-a3b8hyyr	3507	5	range	range	NNP
cord-006860-a3b8hyyr	3507	6	)	)	-RRB-
cord-006860-a3b8hyyr	3507	7	hepadn	hepadn	NNP
cord-006860-a3b8hyyr	3507	8	was	be	VBD
cord-006860-a3b8hyyr	3507	9	administered	administer	VBN
cord-006860-a3b8hyyr	3507	10	in	in	IN
cord-006860-a3b8hyyr	3507	11	a	a	DT
cord-006860-a3b8hyyr	3507	12	total	total	JJ
cord-006860-a3b8hyyr	3507	13	dose	dose	NN
cord-006860-a3b8hyyr	3507	14	of	of	IN
cord-006860-a3b8hyyr	3507	15	60	60	CD
cord-006860-a3b8hyyr	3507	16	(	(	-LRB-
cord-006860-a3b8hyyr	3507	17	17	17	CD
cord-006860-a3b8hyyr	3507	18	-	-	SYM
cord-006860-a3b8hyyr	3507	19	206	206	CD
cord-006860-a3b8hyyr	3507	20	)	)	-RRB-
cord-006860-a3b8hyyr	3507	21	IU	IU	NNP
cord-006860-a3b8hyyr	3507	22	/	/	SYM
cord-006860-a3b8hyyr	3507	23	kg	kg	NNP
cord-006860-a3b8hyyr	3507	24	bw	bw	NNP
cord-006860-a3b8hyyr	3507	25	.	.	.
cord-006860-a3b8hyyr	3508	1	In	in	IN
cord-006860-a3b8hyyr	3508	2	addition	addition	NN
cord-006860-a3b8hyyr	3508	3	infants	infant	NNS
cord-006860-a3b8hyyr	3508	4	<	<	XX
cord-006860-a3b8hyyr	3508	5	6	6	CD
cord-006860-a3b8hyyr	3508	6	months	month	NNS
cord-006860-a3b8hyyr	3508	7	of	of	IN
cord-006860-a3b8hyyr	3508	8	age	age	NN
cord-006860-a3b8hyyr	3508	9	(	(	-LRB-
cord-006860-a3b8hyyr	3508	10	arterial	arterial	JJ
cord-006860-a3b8hyyr	3508	11	catheterisatiun	catheterisatiun	NN
cord-006860-a3b8hyyr	3508	12	only	only	RB
cord-006860-a3b8hyyr	3508	13	)	)	-RRB-
cord-006860-a3b8hyyr	3508	14	or	or	CC
cord-006860-a3b8hyyr	3508	15	patients	patient	NNS
cord-006860-a3b8hyyr	3508	16	with	with	IN
cord-006860-a3b8hyyr	3508	17	known	know	VBN
cord-006860-a3b8hyyr	3508	18	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	3508	19	received	receive	VBD
cord-006860-a3b8hyyr	3508	20	300	300	CD
cord-006860-a3b8hyyr	3508	21	-400	-400	NN
cord-006860-a3b8hyyr	3508	22	IU	IU	NNP
cord-006860-a3b8hyyr	3508	23	/	/	SYM
cord-006860-a3b8hyyr	3508	24	kg	kg	NNP
cord-006860-a3b8hyyr	3508	25	hepafin	hepafin	NNP
cord-006860-a3b8hyyr	3508	26	for	for	IN
cord-006860-a3b8hyyr	3508	27	fmther	fmther	JJ
cord-006860-a3b8hyyr	3508	28	24	24	CD
cord-006860-a3b8hyyr	3508	29	hours	hour	NNS
cord-006860-a3b8hyyr	3508	30	.	.	.
cord-006860-a3b8hyyr	3509	1	The	the	DT
cord-006860-a3b8hyyr	3509	2	results	result	NNS
cord-006860-a3b8hyyr	3509	3	(	(	-LRB-
cord-006860-a3b8hyyr	3509	4	median	median	NN
cord-006860-a3b8hyyr	3509	5	and	and	CC
cord-006860-a3b8hyyr	3509	6	range	range	NN
cord-006860-a3b8hyyr	3509	7	)	)	-RRB-
cord-006860-a3b8hyyr	3509	8	are	be	VBP
cord-006860-a3b8hyyr	3509	9	shown	show	VBN
cord-006860-a3b8hyyr	3509	10	in	in	IN
cord-006860-a3b8hyyr	3509	11	the	the	DT
cord-006860-a3b8hyyr	3509	12	Ft.2	ft.2	NN
cord-006860-a3b8hyyr	3509	13	was	be	VBD
cord-006860-a3b8hyyr	3509	14	sigificanfly	sigificanfly	NN
cord-006860-a3b8hyyr	3509	15	elevated	elevate	VBN
cord-006860-a3b8hyyr	3509	16	above	above	IN
cord-006860-a3b8hyyr	3509	17	the	the	DT
cord-006860-a3b8hyyr	3509	18	pediatric	pediatric	JJ
cord-006860-a3b8hyyr	3509	19	boundary	boundary	NN
cord-006860-a3b8hyyr	3509	20	immediately	immediately	RB
cord-006860-a3b8hyyr	3509	21	after	after	IN
cord-006860-a3b8hyyr	3509	22	the	the	DT
cord-006860-a3b8hyyr	3509	23	intervcation	intervcation	NN
cord-006860-a3b8hyyr	3509	24	and	and	CC
cord-006860-a3b8hyyr	3509	25	nearly	nearly	RB
cord-006860-a3b8hyyr	3509	26	reached	reach	VBD
cord-006860-a3b8hyyr	3509	27	baseline	baseline	JJ
cord-006860-a3b8hyyr	3509	28	values	value	NNS
cord-006860-a3b8hyyr	3509	29	24	24	CD
cord-006860-a3b8hyyr	3509	30	h	h	NN
cord-006860-a3b8hyyr	3509	31	later	later	RB
cord-006860-a3b8hyyr	3509	32	.	.	.
cord-006860-a3b8hyyr	3510	1	In	in	IN
cord-006860-a3b8hyyr	3510	2	contrast	contrast	NN
cord-006860-a3b8hyyr	3510	3	no	no	DT
cord-006860-a3b8hyyr	3510	4	cfinically	cfinically	RB
cord-006860-a3b8hyyr	3510	5	relevant	relevant	JJ
cord-006860-a3b8hyyr	3510	6	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	3510	7	activation	activation	NN
cord-006860-a3b8hyyr	3510	8	was	be	VBD
cord-006860-a3b8hyyr	3510	9	seen	see	VBN
cord-006860-a3b8hyyr	3510	10	:	:	:
cord-006860-a3b8hyyr	3511	1	D	D	NNP
cord-006860-a3b8hyyr	3511	2	-Dimer	-Dimer	.
cord-006860-a3b8hyyr	3512	1	formation	formation	NN
cord-006860-a3b8hyyr	3512	2	increased	increase	VBD
cord-006860-a3b8hyyr	3512	3	within	within	IN
cord-006860-a3b8hyyr	3512	4	the	the	DT
cord-006860-a3b8hyyr	3512	5	pediatric	pediatric	JJ
cord-006860-a3b8hyyr	3512	6	boundary	boundary	NN
cord-006860-a3b8hyyr	3512	7	immediately	immediately	RB
cord-006860-a3b8hyyr	3512	8	after	after	IN
cord-006860-a3b8hyyr	3512	9	the	the	DT
cord-006860-a3b8hyyr	3512	10	catheter	catheter	NN
cord-006860-a3b8hyyr	3512	11	and	and	CC
cord-006860-a3b8hyyr	3512	12	returned	return	VBD
cord-006860-a3b8hyyr	3512	13	to	to	IN
cord-006860-a3b8hyyr	3512	14	basdine	basdine	NNP
cord-006860-a3b8hyyr	3512	15	levels	level	NNS
cord-006860-a3b8hyyr	3512	16	24	24	CD
cord-006860-a3b8hyyr	3512	17	h	h	NN
cord-006860-a3b8hyyr	3512	18	later	later	RB
cord-006860-a3b8hyyr	3512	19	.	.	.
cord-006860-a3b8hyyr	3513	1	Three	three	CD
cord-006860-a3b8hyyr	3513	2	children	child	NNS
cord-006860-a3b8hyyr	3513	3	showed	show	VBD
cord-006860-a3b8hyyr	3513	4	resitance	resitance	NN
cord-006860-a3b8hyyr	3513	5	to	to	IN
cord-006860-a3b8hyyr	3513	6	APC	APC	NNP
cord-006860-a3b8hyyr	3513	7	.	.	.
cord-006860-a3b8hyyr	3514	1	tn	tn	NNP
cord-006860-a3b8hyyr	3514	2	one	one	CD
cord-006860-a3b8hyyr	3514	3	child	child	NN
cord-006860-a3b8hyyr	3514	4	stroke	stroke	NN
cord-006860-a3b8hyyr	3514	5	occurred	occur	VBD
cord-006860-a3b8hyyr	3514	6	before	before	RB
cord-006860-a3b8hyyr	3514	7	.	.	.
cord-006860-a3b8hyyr	3515	1	Not	not	RB
cord-006860-a3b8hyyr	3515	2	knowing	know	VBG
cord-006860-a3b8hyyr	3515	3	the	the	DT
cord-006860-a3b8hyyr	3515	4	result	result	NN
cord-006860-a3b8hyyr	3515	5	of	of	IN
cord-006860-a3b8hyyr	3515	6	APCR	APCR	NNP
cord-006860-a3b8hyyr	3515	7	in	in	IN
cord-006860-a3b8hyyr	3515	8	the	the	DT
cord-006860-a3b8hyyr	3515	9	remaining	remain	VBG
cord-006860-a3b8hyyr	3515	10	two	two	CD
cord-006860-a3b8hyyr	3515	11	patients	patient	NNS
cord-006860-a3b8hyyr	3515	12	only	only	RB
cord-006860-a3b8hyyr	3515	13	one	one	CD
cord-006860-a3b8hyyr	3515	14	neonate	neonate	NN
cord-006860-a3b8hyyr	3515	15	received	receive	VBD
cord-006860-a3b8hyyr	3515	16	further	further	JJ
cord-006860-a3b8hyyr	3515	17	prophylactic	prophylactic	JJ
cord-006860-a3b8hyyr	3515	18	heparin	heparin	NN
cord-006860-a3b8hyyr	3515	19	.	.	.
cord-006860-a3b8hyyr	3516	1	The	the	DT
cord-006860-a3b8hyyr	3516	2	third	third	JJ
cord-006860-a3b8hyyr	3516	3	neonate	neonate	NN
cord-006860-a3b8hyyr	3516	4	without	without	IN
cord-006860-a3b8hyyr	3516	5	heparin	heparin	NN
cord-006860-a3b8hyyr	3516	6	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	3516	7	suffered	suffer	VBD
cord-006860-a3b8hyyr	3516	8	from	from	IN
cord-006860-a3b8hyyr	3516	9	venous	venous	JJ
cord-006860-a3b8hyyr	3516	10	occlusion	occlusion	NN
cord-006860-a3b8hyyr	3516	11	within	within	IN
cord-006860-a3b8hyyr	3516	12	two	two	CD
cord-006860-a3b8hyyr	3516	13	days	day	NNS
cord-006860-a3b8hyyr	3516	14	after	after	RB
cord-006860-a3b8hyyr	3517	1	the	the	DT
cord-006860-a3b8hyyr	3517	2	intervenfon~	intervenfon~	NN
cord-006860-a3b8hyyr	3517	3	In	in	IN
cord-006860-a3b8hyyr	3517	4	addition	addition	NN
cord-006860-a3b8hyyr	3517	5	,	,	,
cord-006860-a3b8hyyr	3517	6	no	no	DT
cord-006860-a3b8hyyr	3517	7	protein	protein	NN
cord-006860-a3b8hyyr	3517	8	C	c	NN
cord-006860-a3b8hyyr	3517	9	,	,	,
cord-006860-a3b8hyyr	3517	10	protein	protein	NN
cord-006860-a3b8hyyr	3517	11	S	s	NN
cord-006860-a3b8hyyr	3517	12	or	or	CC
cord-006860-a3b8hyyr	3517	13	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3517	14	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	3517	15	were	be	VBD
cord-006860-a3b8hyyr	3517	16	found	find	VBN
cord-006860-a3b8hyyr	3517	17	.	.	.
cord-006860-a3b8hyyr	3518	1	Although	although	IN
cord-006860-a3b8hyyr	3518	2	administration	administration	NN
cord-006860-a3b8hyyr	3518	3	of	of	IN
cord-006860-a3b8hyyr	3518	4	low	low	JJ
cord-006860-a3b8hyyr	3518	5	dose	dose	NN
cord-006860-a3b8hyyr	3518	6	flush	flush	JJ
cord-006860-a3b8hyyr	3518	7	heparinisation	heparinisation	NN
cord-006860-a3b8hyyr	3518	8	during	during	IN
cord-006860-a3b8hyyr	3518	9	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	3518	10	cathetefisation	cathetefisation	NN
cord-006860-a3b8hyyr	3518	11	could	could	MD
cord-006860-a3b8hyyr	3518	12	not	not	RB
cord-006860-a3b8hyyr	3518	13	prevent	prevent	VB
cord-006860-a3b8hyyr	3518	14	short	short	JJ
cord-006860-a3b8hyyr	3518	15	-term	-term	HYPH
cord-006860-a3b8hyyr	3518	16	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3518	17	activation	activation	NN
cord-006860-a3b8hyyr	3518	18	,	,	,
cord-006860-a3b8hyyr	3518	19	no	no	DT
cord-006860-a3b8hyyr	3518	20	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	3518	21	events	event	NNS
cord-006860-a3b8hyyr	3518	22	occurred	occur	VBD
cord-006860-a3b8hyyr	3518	23	in	in	IN
cord-006860-a3b8hyyr	3518	24	children	child	NNS
cord-006860-a3b8hyyr	3518	25	without	without	IN
cord-006860-a3b8hyyr	3518	26	inherited	inherit	VBN
cord-006860-a3b8hyyr	3518	27	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	3518	28	.	.	.
cord-006860-a3b8hyyr	3519	1	If	if	IN
cord-006860-a3b8hyyr	3519	2	fnrther	fnrther	JJ
cord-006860-a3b8hyyr	3519	3	prophylactic	prophylactic	JJ
cord-006860-a3b8hyyr	3519	4	hepariuisation	hepariuisation	NN
cord-006860-a3b8hyyr	3519	5	in	in	IN
cord-006860-a3b8hyyr	3519	6	children	child	NNS
cord-006860-a3b8hyyr	3519	7	with	with	IN
cord-006860-a3b8hyyr	3519	8	A	a	DT
cord-006860-a3b8hyyr	3519	9	~	~	NFP
cord-006860-a3b8hyyr	3519	10	R	r	NN
cord-006860-a3b8hyyr	3519	11	,	,	,
cord-006860-a3b8hyyr	3519	12	protein	protein	NN
cord-006860-a3b8hyyr	3519	13	C	c	NN
cord-006860-a3b8hyyr	3519	14	,	,	,
cord-006860-a3b8hyyr	3519	15	protein	protein	NN
cord-006860-a3b8hyyr	3519	16	S	s	NN
cord-006860-a3b8hyyr	3519	17	or	or	CC
cord-006860-a3b8hyyr	3519	18	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3519	19	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	3519	20	may	may	MD
cord-006860-a3b8hyyr	3519	21	prevent	prevent	VB
cord-006860-a3b8hyyr	3519	22	vascular	vascular	JJ
cord-006860-a3b8hyyr	3519	23	occlusion	occlusion	NN
cord-006860-a3b8hyyr	3519	24	requires	require	VBZ
cord-006860-a3b8hyyr	3519	25	a	a	DT
cord-006860-a3b8hyyr	3519	26	more	more	RBR
cord-006860-a3b8hyyr	3519	27	intensive	intensive	JJ
cord-006860-a3b8hyyr	3519	28	study	study	NN
cord-006860-a3b8hyyr	3519	29	.	.	.
cord-006860-a3b8hyyr	3520	1	A.Sandvoss	A.Sandvoss	NNP
cord-006860-a3b8hyyr	3520	2	,	,	,
cord-006860-a3b8hyyr	3520	3	W.Eberl	W.Eberl	NNP
cord-006860-a3b8hyyr	3520	4	,	,	,
cord-006860-a3b8hyyr	3520	5	M.B0rchert	M.B0rchert	NNP
cord-006860-a3b8hyyr	3520	6	Introduction	introduction	NN
cord-006860-a3b8hyyr	3520	7	:	:	:
cord-006860-a3b8hyyr	3521	1	Capillary	capillary	JJ
cord-006860-a3b8hyyr	3521	2	leakage	leakage	NN
cord-006860-a3b8hyyr	3521	3	,	,	,
cord-006860-a3b8hyyr	3521	4	edema	edema	NN
cord-006860-a3b8hyyr	3521	5	and	and	CC
cord-006860-a3b8hyyr	3521	6	hypovolemia	hypovolemia	NN
cord-006860-a3b8hyyr	3521	7	are	be	VBP
cord-006860-a3b8hyyr	3521	8	common	common	JJ
cord-006860-a3b8hyyr	3521	9	complications	complication	NNS
cord-006860-a3b8hyyr	3521	10	in	in	IN
cord-006860-a3b8hyyr	3521	11	preterm	preterm	JJ
cord-006860-a3b8hyyr	3521	12	infants	infant	NNS
cord-006860-a3b8hyyr	3521	13	especially	especially	RB
cord-006860-a3b8hyyr	3521	14	if	if	IN
cord-006860-a3b8hyyr	3521	15	birth	birth	NN
cord-006860-a3b8hyyr	3521	16	weigth	weigth	NN
cord-006860-a3b8hyyr	3521	17	is	be	VBZ
cord-006860-a3b8hyyr	3521	18	below	below	IN
cord-006860-a3b8hyyr	3521	19	1.500	1.500	CD
cord-006860-a3b8hyyr	3521	20	g.	g.	NNP
cord-006860-a3b8hyyr	3521	21	Septicemia	septicemia	NN
cord-006860-a3b8hyyr	3521	22	,	,	,
cord-006860-a3b8hyyr	3521	23	asphyxia	asphyxia	NN
cord-006860-a3b8hyyr	3521	24	and	and	CC
cord-006860-a3b8hyyr	3521	25	immaturity	immaturity	NN
cord-006860-a3b8hyyr	3521	26	seem	seem	VBP
cord-006860-a3b8hyyr	3521	27	to	to	TO
cord-006860-a3b8hyyr	3521	28	be	be	VB
cord-006860-a3b8hyyr	3521	29	most	most	RBS
cord-006860-a3b8hyyr	3521	30	important	important	JJ
cord-006860-a3b8hyyr	3521	31	risk	risk	NN
cord-006860-a3b8hyyr	3521	32	factors	factor	NNS
cord-006860-a3b8hyyr	3521	33	.	.	.
cord-006860-a3b8hyyr	3522	1	To	to	TO
cord-006860-a3b8hyyr	3522	2	determine	determine	VB
cord-006860-a3b8hyyr	3522	3	the	the	DT
cord-006860-a3b8hyyr	3522	4	influence	influence	NN
cord-006860-a3b8hyyr	3522	5	of	of	IN
cord-006860-a3b8hyyr	3522	6	C	C	NNP
cord-006860-a3b8hyyr	3522	7	1-Esterase	1-Esterase	NNP
cord-006860-a3b8hyyr	3522	8	Inhibitor	Inhibitor	NNP
cord-006860-a3b8hyyr	3522	9	(	(	-LRB-
cord-006860-a3b8hyyr	3522	10	CIlNA	cilna	NN
cord-006860-a3b8hyyr	3522	11	)	)	-RRB-
cord-006860-a3b8hyyr	3522	12	in	in	IN
cord-006860-a3b8hyyr	3522	13	preventing	prevent	VBG
cord-006860-a3b8hyyr	3522	14	contact	contact	NN
cord-006860-a3b8hyyr	3522	15	phase	phase	NN
cord-006860-a3b8hyyr	3522	16	and	and	CC
cord-006860-a3b8hyyr	3522	17	complement	complement	NN
cord-006860-a3b8hyyr	3522	18	activation	activation	NN
cord-006860-a3b8hyyr	3522	19	we	-PRON-	PRP
cord-006860-a3b8hyyr	3522	20	investigated	investigate	VBD
cord-006860-a3b8hyyr	3522	21	C11NA	c11na	JJ
cord-006860-a3b8hyyr	3522	22	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3522	23	in	in	IN
cord-006860-a3b8hyyr	3522	24	normal	normal	JJ
cord-006860-a3b8hyyr	3522	25	and	and	CC
cord-006860-a3b8hyyr	3522	26	symptomatic	symptomatic	JJ
cord-006860-a3b8hyyr	3522	27	preterm	preterm	JJ
cord-006860-a3b8hyyr	3522	28	infants	infant	NNS
cord-006860-a3b8hyyr	3522	29	.	.	.
cord-006860-a3b8hyyr	3523	1	Methods	method	NNS
cord-006860-a3b8hyyr	3523	2	:	:	:
cord-006860-a3b8hyyr	3524	1	Activity	activity	NN
cord-006860-a3b8hyyr	3524	2	of	of	IN
cord-006860-a3b8hyyr	3524	3	CIlNA	CIlNA	NNS
cord-006860-a3b8hyyr	3524	4	were	be	VBD
cord-006860-a3b8hyyr	3524	5	measured	measure	VBN
cord-006860-a3b8hyyr	3524	6	by	by	IN
cord-006860-a3b8hyyr	3524	7	chromogenic	chromogenic	NNP
cord-006860-a3b8hyyr	3524	8	substrate	substrate	NN
cord-006860-a3b8hyyr	3524	9	method	method	NN
cord-006860-a3b8hyyr	3524	10	(	(	-LRB-
cord-006860-a3b8hyyr	3524	11	Behringwerke	Behringwerke	NNP
cord-006860-a3b8hyyr	3524	12	)	)	-RRB-
cord-006860-a3b8hyyr	3524	13	,	,	,
cord-006860-a3b8hyyr	3524	14	CIlNA	cilna	NN
cord-006860-a3b8hyyr	3524	15	concentration	concentration	NN
cord-006860-a3b8hyyr	3524	16	with	with	IN
cord-006860-a3b8hyyr	3524	17	radial	radial	JJ
cord-006860-a3b8hyyr	3524	18	immunodiffusion	immunodiffusion	NN
cord-006860-a3b8hyyr	3524	19	(	(	-LRB-
cord-006860-a3b8hyyr	3524	20	Behringwerke	Behringwerke	NNP
cord-006860-a3b8hyyr	3524	21	,	,	,
cord-006860-a3b8hyyr	3524	22	Germany	Germany	NNP
cord-006860-a3b8hyyr	3524	23	)	)	-RRB-
cord-006860-a3b8hyyr	3524	24	.	.	.
cord-006860-a3b8hyyr	3525	1	Results	result	NNS
cord-006860-a3b8hyyr	3525	2	:	:	:
cord-006860-a3b8hyyr	3526	1	CllNA	cllna	NN
cord-006860-a3b8hyyr	3526	2	-	-	HYPH
cord-006860-a3b8hyyr	3526	3	activity	activity	NN
cord-006860-a3b8hyyr	3526	4	in	in	IN
cord-006860-a3b8hyyr	3526	5	asymptomatic	asymptomatic	JJ
cord-006860-a3b8hyyr	3526	6	preterm	preterm	JJ
cord-006860-a3b8hyyr	3526	7	infants	infant	NNS
cord-006860-a3b8hyyr	3526	8	(	(	-LRB-
cord-006860-a3b8hyyr	3526	9	n=	n=	NNP
cord-006860-a3b8hyyr	3526	10	14	14	CD
cord-006860-a3b8hyyr	3526	11	)	)	-RRB-
cord-006860-a3b8hyyr	3526	12	was	be	VBD
cord-006860-a3b8hyyr	3526	13	65+/-15	65+/-15	CD
cord-006860-a3b8hyyr	3526	14	%	%	NN
cord-006860-a3b8hyyr	3526	15	of	of	IN
cord-006860-a3b8hyyr	3526	16	normal	normal	JJ
cord-006860-a3b8hyyr	3526	17	at	at	IN
cord-006860-a3b8hyyr	3526	18	birth	birth	NN
cord-006860-a3b8hyyr	3526	19	.	.	.
cord-006860-a3b8hyyr	3527	1	Healthy	healthy	JJ
cord-006860-a3b8hyyr	3527	2	newborns	newborn	NNS
cord-006860-a3b8hyyr	3527	3	showed	show	VBD
cord-006860-a3b8hyyr	3527	4	activities	activity	NNS
cord-006860-a3b8hyyr	3527	5	of	of	IN
cord-006860-a3b8hyyr	3527	6	80+/-20	80+/-20	CD
cord-006860-a3b8hyyr	3527	7	%	%	NN
cord-006860-a3b8hyyr	3527	8	.	.	.
cord-006860-a3b8hyyr	3528	1	CIlNA	CIlNA	NNP
cord-006860-a3b8hyyr	3528	2	reached	reach	VBD
cord-006860-a3b8hyyr	3528	3	normal	normal	JJ
cord-006860-a3b8hyyr	3528	4	adult	adult	NN
cord-006860-a3b8hyyr	3528	5	values	value	NNS
cord-006860-a3b8hyyr	3528	6	2	2	CD
cord-006860-a3b8hyyr	3528	7	-	-	SYM
cord-006860-a3b8hyyr	3528	8	4	4	CD
cord-006860-a3b8hyyr	3528	9	days	day	NNS
cord-006860-a3b8hyyr	3528	10	after	after	IN
cord-006860-a3b8hyyr	3528	11	birth	birth	NN
cord-006860-a3b8hyyr	3528	12	.	.	.
cord-006860-a3b8hyyr	3529	1	Preterm	preterm	JJ
cord-006860-a3b8hyyr	3529	2	infants	infant	NNS
cord-006860-a3b8hyyr	3529	3	with	with	IN
cord-006860-a3b8hyyr	3529	4	respiratory	respiratory	JJ
cord-006860-a3b8hyyr	3529	5	distress	distress	NN
cord-006860-a3b8hyyr	3529	6	syndrome(n	syndrome(n	NN
cord-006860-a3b8hyyr	3529	7	=	=	SYM
cord-006860-a3b8hyyr	3529	8	14	14	CD
cord-006860-a3b8hyyr	3529	9	)	)	-RRB-
cord-006860-a3b8hyyr	3529	10	showed	show	VBD
cord-006860-a3b8hyyr	3529	11	lower	low	JJR
cord-006860-a3b8hyyr	3529	12	activity	activity	NN
cord-006860-a3b8hyyr	3529	13	on	on	IN
cord-006860-a3b8hyyr	3529	14	day	day	NN
cord-006860-a3b8hyyr	3529	15	2	2	CD
cord-006860-a3b8hyyr	3529	16	-	-	SYM
cord-006860-a3b8hyyr	3529	17	5	5	CD
cord-006860-a3b8hyyr	3529	18	,	,	,
cord-006860-a3b8hyyr	3529	19	patients	patient	NNS
cord-006860-a3b8hyyr	3529	20	with	with	IN
cord-006860-a3b8hyyr	3529	21	additional	additional	JJ
cord-006860-a3b8hyyr	3529	22	septicemia	septicemia	NN
cord-006860-a3b8hyyr	3529	23	(	(	-LRB-
cord-006860-a3b8hyyr	3529	24	n=15	n=15	NNP
cord-006860-a3b8hyyr	3529	25	)	)	-RRB-
cord-006860-a3b8hyyr	3529	26	had	have	VBD
cord-006860-a3b8hyyr	3529	27	decreasing	decrease	VBG
cord-006860-a3b8hyyr	3529	28	C1	C1	NNP
cord-006860-a3b8hyyr	3529	29	INA	INA	NNP
cord-006860-a3b8hyyr	3529	30	-	-	HYPH
cord-006860-a3b8hyyr	3529	31	activities	activity	NNS
cord-006860-a3b8hyyr	3529	32	in	in	IN
cord-006860-a3b8hyyr	3529	33	the	the	DT
cord-006860-a3b8hyyr	3529	34	first	first	JJ
cord-006860-a3b8hyyr	3529	35	three	three	CD
cord-006860-a3b8hyyr	3529	36	days	day	NNS
cord-006860-a3b8hyyr	3529	37	of	of	IN
cord-006860-a3b8hyyr	3529	38	life	life	NN
cord-006860-a3b8hyyr	3529	39	.	.	.
cord-006860-a3b8hyyr	3530	1	Individual	individual	JJ
cord-006860-a3b8hyyr	3530	2	course	course	NN
cord-006860-a3b8hyyr	3530	3	of	of	IN
cord-006860-a3b8hyyr	3530	4	CllNA	cllna	NN
cord-006860-a3b8hyyr	3530	5	-	-	HYPH
cord-006860-a3b8hyyr	3530	6	activity	activity	NN
cord-006860-a3b8hyyr	3530	7	and	and	CC
cord-006860-a3b8hyyr	3530	8	thrombocyte	thrombocyte	NN
cord-006860-a3b8hyyr	3530	9	count	count	NNP
cord-006860-a3b8hyyr	3530	10	correlated	correlate	VBN
cord-006860-a3b8hyyr	3530	11	in	in	IN
cord-006860-a3b8hyyr	3530	12	the	the	DT
cord-006860-a3b8hyyr	3530	13	group	group	NN
cord-006860-a3b8hyyr	3530	14	with	with	IN
cord-006860-a3b8hyyr	3530	15	IRDS	IRDS	NNP
cord-006860-a3b8hyyr	3530	16	with	with	IN
cord-006860-a3b8hyyr	3530	17	and	and	CC
cord-006860-a3b8hyyr	3530	18	without	without	IN
cord-006860-a3b8hyyr	3530	19	septicemia	septicemia	NN
cord-006860-a3b8hyyr	3530	20	.	.	.
cord-006860-a3b8hyyr	3531	1	In	in	IN
cord-006860-a3b8hyyr	3531	2	children	child	NNS
cord-006860-a3b8hyyr	3531	3	with	with	IN
cord-006860-a3b8hyyr	3531	4	capillary	capillary	JJ
cord-006860-a3b8hyyr	3531	5	leakage	leakage	NN
cord-006860-a3b8hyyr	3531	6	onset	onset	NN
cord-006860-a3b8hyyr	3531	7	of	of	IN
cord-006860-a3b8hyyr	3531	8	diuresis	diuresis	NN
cord-006860-a3b8hyyr	3531	9	went	go	VBD
cord-006860-a3b8hyyr	3531	10	parallel	parallel	JJ
cord-006860-a3b8hyyr	3531	11	with	with	IN
cord-006860-a3b8hyyr	3531	12	raising	raise	VBG
cord-006860-a3b8hyyr	3531	13	CllNA	cllna	NN
cord-006860-a3b8hyyr	3531	14	-	-	HYPH
cord-006860-a3b8hyyr	3531	15	activity	activity	NN
cord-006860-a3b8hyyr	3531	16	.	.	.
cord-006860-a3b8hyyr	3532	1	Markers	marker	NNS
cord-006860-a3b8hyyr	3532	2	of	of	IN
cord-006860-a3b8hyyr	3532	3	contact	contact	NN
cord-006860-a3b8hyyr	3532	4	phase	phase	NN
cord-006860-a3b8hyyr	3532	5	(	(	-LRB-
cord-006860-a3b8hyyr	3532	6	F	F	NNP
cord-006860-a3b8hyyr	3532	7	Xlla	Xlla	NNP
cord-006860-a3b8hyyr	3532	8	)	)	-RRB-
cord-006860-a3b8hyyr	3532	9	and	and	CC
cord-006860-a3b8hyyr	3532	10	complement	complement	VB
cord-006860-a3b8hyyr	3532	11	activation	activation	NN
cord-006860-a3b8hyyr	3532	12	(	(	-LRB-
cord-006860-a3b8hyyr	3532	13	C	C	NNP
cord-006860-a3b8hyyr	3532	14	5al	5al	NNP
cord-006860-a3b8hyyr	3532	15	were	be	VBD
cord-006860-a3b8hyyr	3532	16	investigated	investigate	VBN
cord-006860-a3b8hyyr	3532	17	in	in	IN
cord-006860-a3b8hyyr	3532	18	single	single	JJ
cord-006860-a3b8hyyr	3532	19	cases	case	NNS
cord-006860-a3b8hyyr	3532	20	and	and	CC
cord-006860-a3b8hyyr	3532	21	evidence	evidence	NN
cord-006860-a3b8hyyr	3532	22	for	for	IN
cord-006860-a3b8hyyr	3532	23	involvement	involvement	NN
cord-006860-a3b8hyyr	3532	24	of	of	IN
cord-006860-a3b8hyyr	3532	25	both	both	DT
cord-006860-a3b8hyyr	3532	26	systems	system	NNS
cord-006860-a3b8hyyr	3532	27	was	be	VBD
cord-006860-a3b8hyyr	3532	28	found	find	VBN
cord-006860-a3b8hyyr	3532	29	.	.	.
cord-006860-a3b8hyyr	3533	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	3533	2	:	:	:
cord-006860-a3b8hyyr	3533	3	Contact	contact	NN
cord-006860-a3b8hyyr	3533	4	activation	activation	NN
cord-006860-a3b8hyyr	3533	5	and	and	CC
cord-006860-a3b8hyyr	3533	6	complement	complement	NN
cord-006860-a3b8hyyr	3533	7	system	system	NN
cord-006860-a3b8hyyr	3533	8	play	play	VBP
cord-006860-a3b8hyyr	3533	9	an	an	DT
cord-006860-a3b8hyyr	3533	10	important	important	JJ
cord-006860-a3b8hyyr	3533	11	role	role	NN
cord-006860-a3b8hyyr	3533	12	in	in	IN
cord-006860-a3b8hyyr	3533	13	capillary	capillary	JJ
cord-006860-a3b8hyyr	3533	14	leakage	leakage	NN
cord-006860-a3b8hyyr	3533	15	in	in	IN
cord-006860-a3b8hyyr	3533	16	preterm	preterm	JJ
cord-006860-a3b8hyyr	3533	17	infants	infant	NNS
cord-006860-a3b8hyyr	3533	18	.	.	.
cord-006860-a3b8hyyr	3534	1	CIlNA	CIlNA	NNP
cord-006860-a3b8hyyr	3534	2	regulates	regulate	VBZ
cord-006860-a3b8hyyr	3534	3	both	both	DT
cord-006860-a3b8hyyr	3534	4	systems	system	NNS
cord-006860-a3b8hyyr	3534	5	.	.	.
cord-006860-a3b8hyyr	3535	1	Activity	activity	NN
cord-006860-a3b8hyyr	3535	2	of	of	IN
cord-006860-a3b8hyyr	3535	3	CIlNA	CIlNA	NNP
cord-006860-a3b8hyyr	3535	4	correlates	correlate	VBZ
cord-006860-a3b8hyyr	3535	5	with	with	IN
cord-006860-a3b8hyyr	3535	6	clinical	clinical	JJ
cord-006860-a3b8hyyr	3535	7	course	course	NN
cord-006860-a3b8hyyr	3535	8	,	,	,
cord-006860-a3b8hyyr	3535	9	substitution	substitution	NN
cord-006860-a3b8hyyr	3535	10	therapy	therapy	NN
cord-006860-a3b8hyyr	3535	11	is	be	VBZ
cord-006860-a3b8hyyr	3535	12	possible	possible	JJ
cord-006860-a3b8hyyr	3535	13	and	and	CC
cord-006860-a3b8hyyr	3535	14	may	may	MD
cord-006860-a3b8hyyr	3535	15	improve	improve	VB
cord-006860-a3b8hyyr	3535	16	outcome	outcome	NN
cord-006860-a3b8hyyr	3535	17	of	of	IN
cord-006860-a3b8hyyr	3535	18	these	these	DT
cord-006860-a3b8hyyr	3535	19	critical	critical	JJ
cord-006860-a3b8hyyr	3535	20	ill	ill	JJ
cord-006860-a3b8hyyr	3535	21	patients	patient	NNS
cord-006860-a3b8hyyr	3535	22	.	.	.
cord-006860-a3b8hyyr	3536	1	Antiphospholipid	Antiphospholipid	NNP
cord-006860-a3b8hyyr	3536	2	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3536	3	(	(	-LRB-
cord-006860-a3b8hyyr	3536	4	APA	APA	NNP
cord-006860-a3b8hyyr	3536	5	)	)	-RRB-
cord-006860-a3b8hyyr	3536	6	interfere	interfere	VB
cord-006860-a3b8hyyr	3536	7	with	with	IN
cord-006860-a3b8hyyr	3536	8	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	3536	9	probably	probably	RB
cord-006860-a3b8hyyr	3536	10	by	by	IN
cord-006860-a3b8hyyr	3536	11	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3536	12	of	of	IN
cord-006860-a3b8hyyr	3536	13	protein	protein	NN
cord-006860-a3b8hyyr	3536	14	C	C	NNP
cord-006860-a3b8hyyr	3536	15	or	or	CC
cord-006860-a3b8hyyr	3536	16	prothrombinase	prothrombinase	NNP
cord-006860-a3b8hyyr	3536	17	complex	complex	NNP
cord-006860-a3b8hyyr	3536	18	.	.	.
cord-006860-a3b8hyyr	3537	1	Thereby	thereby	RB
cord-006860-a3b8hyyr	3537	2	,	,	,
cord-006860-a3b8hyyr	3537	3	APA	APA	NNP
cord-006860-a3b8hyyr	3537	4	might	may	MD
cord-006860-a3b8hyyr	3537	5	lead	lead	VB
cord-006860-a3b8hyyr	3537	6	to	to	IN
cord-006860-a3b8hyyr	3537	7	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3537	8	or	or	CC
cord-006860-a3b8hyyr	3537	9	increased	increase	VBN
cord-006860-a3b8hyyr	3537	10	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3537	11	.	.	.
cord-006860-a3b8hyyr	3538	1	However	however	RB
cord-006860-a3b8hyyr	3538	2	,	,	,
cord-006860-a3b8hyyr	3538	3	incidence	incidence	NN
cord-006860-a3b8hyyr	3538	4	and	and	CC
cord-006860-a3b8hyyr	3538	5	clinical	clinical	JJ
cord-006860-a3b8hyyr	3538	6	importance	importance	NN
cord-006860-a3b8hyyr	3538	7	of	of	IN
cord-006860-a3b8hyyr	3538	8	APA	APA	NNP
cord-006860-a3b8hyyr	3538	9	has	have	VBZ
cord-006860-a3b8hyyr	3538	10	not	not	RB
cord-006860-a3b8hyyr	3538	11	yet	yet	RB
cord-006860-a3b8hyyr	3538	12	been	be	VBN
cord-006860-a3b8hyyr	3538	13	investigated	investigate	VBN
cord-006860-a3b8hyyr	3538	14	in	in	IN
cord-006860-a3b8hyyr	3538	15	children	child	NNS
cord-006860-a3b8hyyr	3538	16	.	.	.
cord-006860-a3b8hyyr	3539	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	3539	2	,	,	,
cord-006860-a3b8hyyr	3539	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	3539	4	assayed	assay	VBD
cord-006860-a3b8hyyr	3539	5	plasma	plasma	NN
cord-006860-a3b8hyyr	3539	6	samples	sample	NNS
cord-006860-a3b8hyyr	3539	7	of	of	IN
cord-006860-a3b8hyyr	3539	8	220	220	CD
cord-006860-a3b8hyyr	3539	9	children	child	NNS
cord-006860-a3b8hyyr	3539	10	,	,	,
cord-006860-a3b8hyyr	3539	11	aged	aged	JJ
cord-006860-a3b8hyyr	3539	12	0,1	0,1	CD
cord-006860-a3b8hyyr	3539	13	to	to	TO
cord-006860-a3b8hyyr	3539	14	19	19	CD
cord-006860-a3b8hyyr	3539	15	years	year	NNS
cord-006860-a3b8hyyr	3540	1	(	(	-LRB-
cord-006860-a3b8hyyr	3540	2	mean	mean	VB
cord-006860-a3b8hyyr	3540	3	7	7	CD
cord-006860-a3b8hyyr	3540	4	years	year	NNS
cord-006860-a3b8hyyr	3540	5	)	)	-RRB-
cord-006860-a3b8hyyr	3540	6	by	by	IN
cord-006860-a3b8hyyr	3540	7	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	3540	8	detecting	detect	VBG
cord-006860-a3b8hyyr	3540	9	IgG	IgG	NNP
cord-006860-a3b8hyyr	3540	10	-	-	HYPH
cord-006860-a3b8hyyr	3540	11	and	and	CC
cord-006860-a3b8hyyr	3540	12	lgM	lgM	NNP
cord-006860-a3b8hyyr	3540	13	-	-	HYPH
cord-006860-a3b8hyyr	3540	14	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3540	15	directed	direct	VBN
cord-006860-a3b8hyyr	3540	16	against	against	IN
cord-006860-a3b8hyyr	3540	17	eardiolipin	eardiolipin	NNP
cord-006860-a3b8hyyr	3540	18	,	,	,
cord-006860-a3b8hyyr	3540	19	phosphatidyl	phosphatidyl	NNP
cord-006860-a3b8hyyr	3540	20	serine	serine	NNP
cord-006860-a3b8hyyr	3540	21	and	and	CC
cord-006860-a3b8hyyr	3540	22	phosphatidic	phosphatidic	JJ
cord-006860-a3b8hyyr	3540	23	acid	acid	NN
cord-006860-a3b8hyyr	3540	24	.	.	.
cord-006860-a3b8hyyr	3541	1	In	in	IN
cord-006860-a3b8hyyr	3541	2	patients	patient	NNS
cord-006860-a3b8hyyr	3541	3	with	with	IN
cord-006860-a3b8hyyr	3541	4	increased	increase	VBN
cord-006860-a3b8hyyr	3541	5	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3541	6	,	,	,
cord-006860-a3b8hyyr	3541	7	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	3541	8	or	or	CC
cord-006860-a3b8hyyr	3541	9	prolonged	prolonged	JJ
cord-006860-a3b8hyyr	3541	10	clotting	clotting	NN
cord-006860-a3b8hyyr	3541	11	tests	test	VBZ
cord-006860-a3b8hyyr	3541	12	a	a	DT
cord-006860-a3b8hyyr	3541	13	detailed	detailed	JJ
cord-006860-a3b8hyyr	3541	14	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3541	15	analysis	analysis	NN
cord-006860-a3b8hyyr	3541	16	was	be	VBD
cord-006860-a3b8hyyr	3541	17	performed	perform	VBN
cord-006860-a3b8hyyr	3541	18	.	.	.
cord-006860-a3b8hyyr	3542	1	According	accord	VBG
cord-006860-a3b8hyyr	3542	2	to	to	IN
cord-006860-a3b8hyyr	3542	3	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3542	4	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	3542	5	children	child	NNS
cord-006860-a3b8hyyr	3542	6	were	be	VBD
cord-006860-a3b8hyyr	3542	7	devided	devide	VBN
cord-006860-a3b8hyyr	3542	8	into	into	IN
cord-006860-a3b8hyyr	3542	9	5	5	CD
cord-006860-a3b8hyyr	3542	10	groups	group	NNS
cord-006860-a3b8hyyr	3542	11	:	:	:
cord-006860-a3b8hyyr	3542	12	I.	I.	NNP
cord-006860-a3b8hyyr	3542	13	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	3542	14	diseases	disease	NNS
cord-006860-a3b8hyyr	3542	15	,	,	,
cord-006860-a3b8hyyr	3542	16	II	II	NNP
cord-006860-a3b8hyyr	3542	17	.	.	.
cord-006860-a3b8hyyr	3543	1	infections	infection	NNS
cord-006860-a3b8hyyr	3543	2	,	,	,
cord-006860-a3b8hyyr	3543	3	III	III	NNP
cord-006860-a3b8hyyr	3543	4	.	.	.
cord-006860-a3b8hyyr	3544	1	metabolic	metabolic	JJ
cord-006860-a3b8hyyr	3544	2	diseases	disease	NNS
cord-006860-a3b8hyyr	3544	3	,	,	,
cord-006860-a3b8hyyr	3544	4	IV	IV	NNP
cord-006860-a3b8hyyr	3544	5	.	.	.
cord-006860-a3b8hyyr	3545	1	other	other	JJ
cord-006860-a3b8hyyr	3545	2	diseases	disease	NNS
cord-006860-a3b8hyyr	3545	3	,	,	,
cord-006860-a3b8hyyr	3545	4	V.	V.	NNP
cord-006860-a3b8hyyr	3545	5	healthy	healthy	JJ
cord-006860-a3b8hyyr	3545	6	children	child	NNS
cord-006860-a3b8hyyr	3545	7	.	.	.
cord-006860-a3b8hyyr	3546	1	Results	result	NNS
cord-006860-a3b8hyyr	3546	2	:	:	:
cord-006860-a3b8hyyr	3547	1	APA	APA	NNP
cord-006860-a3b8hyyr	3547	2	were	be	VBD
cord-006860-a3b8hyyr	3547	3	found	find	VBN
cord-006860-a3b8hyyr	3547	4	in	in	IN
cord-006860-a3b8hyyr	3547	5	69/220	69/220	CD
cord-006860-a3b8hyyr	3547	6	patients	patient	NNS
cord-006860-a3b8hyyr	3547	7	.	.	.
cord-006860-a3b8hyyr	3548	1	In	in	IN
cord-006860-a3b8hyyr	3548	2	the	the	DT
cord-006860-a3b8hyyr	3548	3	respective	respective	JJ
cord-006860-a3b8hyyr	3548	4	groups	group	NNS
cord-006860-a3b8hyyr	3548	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	3548	6	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	3548	7	APA	apa	NN
cord-006860-a3b8hyyr	3548	8	in	in	IN
cord-006860-a3b8hyyr	3548	9	the	the	DT
cord-006860-a3b8hyyr	3548	10	following	follow	VBG
cord-006860-a3b8hyyr	3548	11	proportions	proportion	NNS
cord-006860-a3b8hyyr	3548	12	:	:	:
cord-006860-a3b8hyyr	3548	13	1	1	CD
cord-006860-a3b8hyyr	3548	14	.	.	.
cord-006860-a3b8hyyr	3549	1	lgG	lgG	NNP
cord-006860-a3b8hyyr	3549	2	-	-	HYPH
cord-006860-a3b8hyyr	3549	3	isotype	isotype	NN
cord-006860-a3b8hyyr	3549	4	:	:	:
cord-006860-a3b8hyyr	3550	1	Activitiy	Activitiy	NNP
cord-006860-a3b8hyyr	3550	2	of	of	IN
cord-006860-a3b8hyyr	3550	3	C1	C1	NNP
cord-006860-a3b8hyyr	3550	4	Esterase	Esterase	NNP
cord-006860-a3b8hyyr	3550	5	Inhibitor	Inhibitor	NNP
cord-006860-a3b8hyyr	3550	6	(	(	-LRB-
cord-006860-a3b8hyyr	3550	7	C11NA	C11NA	NNP
cord-006860-a3b8hyyr	3550	8	)	)	-RRB-
cord-006860-a3b8hyyr	3550	9	is	be	VBZ
cord-006860-a3b8hyyr	3550	10	reduced	reduce	VBN
cord-006860-a3b8hyyr	3550	11	in	in	IN
cord-006860-a3b8hyyr	3550	12	preterm	preterm	JJ
cord-006860-a3b8hyyr	3550	13	infants	infant	NNS
cord-006860-a3b8hyyr	3550	14	especially	especially	RB
cord-006860-a3b8hyyr	3550	15	if	if	IN
cord-006860-a3b8hyyr	3550	16	birth	birth	NN
cord-006860-a3b8hyyr	3550	17	weigth	weigth	NN
cord-006860-a3b8hyyr	3550	18	is	be	VBZ
cord-006860-a3b8hyyr	3550	19	below	below	IN
cord-006860-a3b8hyyr	3550	20	1.500	1.500	CD
cord-006860-a3b8hyyr	3550	21	g	g	NN
cord-006860-a3b8hyyr	3550	22	and	and	CC
cord-006860-a3b8hyyr	3550	23	respiratory	respiratory	JJ
cord-006860-a3b8hyyr	3550	24	distress	distress	NN
cord-006860-a3b8hyyr	3550	25	syndrome	syndrome	NN
cord-006860-a3b8hyyr	3550	26	and/or	and/or	CC
cord-006860-a3b8hyyr	3550	27	septicemia	septicemia	NN
cord-006860-a3b8hyyr	3550	28	is	be	VBZ
cord-006860-a3b8hyyr	3550	29	present	present	JJ
cord-006860-a3b8hyyr	3550	30	.	.	.
cord-006860-a3b8hyyr	3551	1	Capillary	capillary	JJ
cord-006860-a3b8hyyr	3551	2	leakage	leakage	NN
cord-006860-a3b8hyyr	3551	3	with	with	IN
cord-006860-a3b8hyyr	3551	4	generalized	generalized	JJ
cord-006860-a3b8hyyr	3551	5	edema	edema	NN
cord-006860-a3b8hyyr	3551	6	,	,	,
cord-006860-a3b8hyyr	3551	7	hypovolemia	hypovolemia	NN
cord-006860-a3b8hyyr	3551	8	and	and	CC
cord-006860-a3b8hyyr	3551	9	hypotension	hypotension	NN
cord-006860-a3b8hyyr	3551	10	is	be	VBZ
cord-006860-a3b8hyyr	3551	11	resulting	result	VBG
cord-006860-a3b8hyyr	3551	12	in	in	IN
cord-006860-a3b8hyyr	3551	13	imbalance	imbalance	NN
cord-006860-a3b8hyyr	3551	14	between	between	IN
cord-006860-a3b8hyyr	3551	15	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3551	16	and	and	CC
cord-006860-a3b8hyyr	3551	17	activation	activation	NN
cord-006860-a3b8hyyr	3551	18	of	of	IN
cord-006860-a3b8hyyr	3551	19	contact	contact	NN
cord-006860-a3b8hyyr	3551	20	phase	phase	NN
cord-006860-a3b8hyyr	3551	21	and	and	CC
cord-006860-a3b8hyyr	3551	22	complement	complement	VB
cord-006860-a3b8hyyr	3551	23	system	system	NN
cord-006860-a3b8hyyr	3551	24	.	.	.
cord-006860-a3b8hyyr	3552	1	iln	iln	NNP
cord-006860-a3b8hyyr	3552	2	four	four	CD
cord-006860-a3b8hyyr	3552	3	patients	patient	NNS
cord-006860-a3b8hyyr	3552	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	3552	5	investigated	investigate	VBD
cord-006860-a3b8hyyr	3552	6	seven	seven	CD
cord-006860-a3b8hyyr	3552	7	courses	course	NNS
cord-006860-a3b8hyyr	3552	8	of	of	IN
cord-006860-a3b8hyyr	3552	9	substitution	substitution	NN
cord-006860-a3b8hyyr	3552	10	;	;	:
cord-006860-a3b8hyyr	3552	11	with	with	IN
cord-006860-a3b8hyyr	3552	12	commercial	commercial	JJ
cord-006860-a3b8hyyr	3552	13	C1	C1	NNP
cord-006860-a3b8hyyr	3552	14	Esterase	Esterase	NNP
cord-006860-a3b8hyyr	3552	15	Inhibitor	Inhibitor	NNP
cord-006860-a3b8hyyr	3552	16	preparation	preparation	NN
cord-006860-a3b8hyyr	3552	17	(	(	-LRB-
cord-006860-a3b8hyyr	3552	18	Berinertr	Berinertr	NNP
cord-006860-a3b8hyyr	3552	19	,	,	,
cord-006860-a3b8hyyr	3552	20	Behringwerke	Behringwerke	NNP
cord-006860-a3b8hyyr	3552	21	)	)	-RRB-
cord-006860-a3b8hyyr	3552	22	,	,	,
cord-006860-a3b8hyyr	3552	23	case	case	NN
cord-006860-a3b8hyyr	3552	24	reports	report	NNS
cord-006860-a3b8hyyr	3552	25	are	be	VBP
cord-006860-a3b8hyyr	3552	26	given	give	VBN
cord-006860-a3b8hyyr	3552	27	.	.	.
cord-006860-a3b8hyyr	3553	1	All	all	DT
cord-006860-a3b8hyyr	3553	2	patients	patient	NNS
cord-006860-a3b8hyyr	3553	3	had	have	VBD
cord-006860-a3b8hyyr	3553	4	clinical	clinical	JJ
cord-006860-a3b8hyyr	3553	5	symptoms	symptom	NNS
cord-006860-a3b8hyyr	3553	6	of	of	IN
cord-006860-a3b8hyyr	3553	7	capillary	capillary	JJ
cord-006860-a3b8hyyr	3553	8	leakage	leakage	NN
cord-006860-a3b8hyyr	3553	9	,	,	,
cord-006860-a3b8hyyr	3553	10	all	all	DT
cord-006860-a3b8hyyr	3553	11	had	have	VBD
cord-006860-a3b8hyyr	3553	12	septicemia	septicemia	NN
cord-006860-a3b8hyyr	3553	13	accompanied	accompany	VBN
cord-006860-a3b8hyyr	3553	14	by	by	IN
cord-006860-a3b8hyyr	3553	15	either	either	DT
cord-006860-a3b8hyyr	3553	16	respiratory	respiratory	JJ
cord-006860-a3b8hyyr	3553	17	distress	distress	NN
cord-006860-a3b8hyyr	3553	18	,	,	,
cord-006860-a3b8hyyr	3553	19	disiseminated	disiseminate	VBN
cord-006860-a3b8hyyr	3553	20	intravascular	intravascular	JJ
cord-006860-a3b8hyyr	3553	21	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3553	22	or	or	CC
cord-006860-a3b8hyyr	3553	23	mutiple	mutiple	JJ
cord-006860-a3b8hyyr	3553	24	organ	organ	NN
cord-006860-a3b8hyyr	3553	25	failure	failure	NN
cord-006860-a3b8hyyr	3553	26	.	.	.
cord-006860-a3b8hyyr	3554	1	jEfficiacy	jEfficiacy	NNP
cord-006860-a3b8hyyr	3554	2	of	of	IN
cord-006860-a3b8hyyr	3554	3	substitution	substitution	NN
cord-006860-a3b8hyyr	3554	4	therapy	therapy	NN
cord-006860-a3b8hyyr	3554	5	is	be	VBZ
cord-006860-a3b8hyyr	3554	6	dose	dose	RB
cord-006860-a3b8hyyr	3554	7	related	relate	VBN
cord-006860-a3b8hyyr	3554	8	,	,	,
cord-006860-a3b8hyyr	3554	9	supranormal	supranormal	JJ
cord-006860-a3b8hyyr	3554	10	iactivities	iactivitie	NNS
cord-006860-a3b8hyyr	3554	11	of	of	IN
cord-006860-a3b8hyyr	3554	12	CIlNA	CIlNA	NNS
cord-006860-a3b8hyyr	3554	13	are	be	VBP
cord-006860-a3b8hyyr	3554	14	necessary	necessary	JJ
cord-006860-a3b8hyyr	3554	15	,	,	,
cord-006860-a3b8hyyr	3554	16	reflecting	reflect	VBG
cord-006860-a3b8hyyr	3554	17	raised	raise	VBN
cord-006860-a3b8hyyr	3554	18	consumption	consumption	NN
cord-006860-a3b8hyyr	3554	19	of	of	IN
cord-006860-a3b8hyyr	3554	20	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3554	21	in	in	IN
cord-006860-a3b8hyyr	3554	22	ongoing	ongoing	JJ
cord-006860-a3b8hyyr	3554	23	disease	disease	NN
cord-006860-a3b8hyyr	3554	24	.	.	.
cord-006860-a3b8hyyr	3555	1	Clinical	clinical	JJ
cord-006860-a3b8hyyr	3555	2	effects	effect	NNS
cord-006860-a3b8hyyr	3555	3	on	on	IN
cord-006860-a3b8hyyr	3555	4	diuresis	diuresis	NN
cord-006860-a3b8hyyr	3555	5	,	,	,
cord-006860-a3b8hyyr	3555	6	catecholamine	catecholamine	NN
cord-006860-a3b8hyyr	3555	7	need	need	NN
cord-006860-a3b8hyyr	3555	8	and	and	CC
cord-006860-a3b8hyyr	3555	9	especially	especially	RB
cord-006860-a3b8hyyr	3555	10	on	on	IN
cord-006860-a3b8hyyr	3555	11	thrombocyte	thrombocyte	NNP
cord-006860-a3b8hyyr	3555	12	counts	count	NNS
cord-006860-a3b8hyyr	3555	13	are	be	VBP
cord-006860-a3b8hyyr	3555	14	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	3555	15	.	.	.
cord-006860-a3b8hyyr	3556	1	OR	or	CC
cord-006860-a3b8hyyr	3556	2	ARTERIAL	arterial	NN
cord-006860-a3b8hyyr	3556	3	THROMBOEMBOLIC	THROMBOEMBOLIC	NNP
cord-006860-a3b8hyyr	3556	4	EVENT	event	NN
cord-006860-a3b8hyyr	3556	5	IN	in	IN
cord-006860-a3b8hyyr	3556	6	CHILDREN	child	NNS
cord-006860-a3b8hyyr	3556	7	E.	E.	NNP
cord-006860-a3b8hyyr	3556	8	Lenz	Lenz	NNP
cord-006860-a3b8hyyr	3556	9	,	,	,
cord-006860-a3b8hyyr	3556	10	C.	C.	NNP
cord-006860-a3b8hyyr	3556	11	Heller	Heller	NNP
cord-006860-a3b8hyyr	3556	12	,	,	,
cord-006860-a3b8hyyr	3557	1	W.	W.	NNP
cord-006860-a3b8hyyr	3557	2	Schr6ter	Schr6ter	NNP
cord-006860-a3b8hyyr	3557	3	*	*	NFP
cord-006860-a3b8hyyr	3557	4	,	,	,
cord-006860-a3b8hyyr	3557	5	W.	W.	NNP
cord-006860-a3b8hyyr	3557	6	Kreuz	Kreuz	NNP
cord-006860-a3b8hyyr	3557	7	Johann	Johann	NNP
cord-006860-a3b8hyyr	3557	8	W.	W.	NNP
cord-006860-a3b8hyyr	3557	9	Goethe	Goethe	NNP
cord-006860-a3b8hyyr	3557	10	-	-	HYPH
cord-006860-a3b8hyyr	3557	11	Universit	Universit	NNP
cord-006860-a3b8hyyr	3558	1	~itskinderklinlk	~itskinderklinlk	NNP
cord-006860-a3b8hyyr	3558	2	,	,	,
cord-006860-a3b8hyyr	3558	3	Frankfurt	Frankfurt	NNP
cord-006860-a3b8hyyr	3558	4	a.	a.	NN
cord-006860-a3b8hyyr	3558	5	Main	Main	NNP
cord-006860-a3b8hyyr	3558	6	,	,	,
cord-006860-a3b8hyyr	3558	7	Germany	Germany	NNP
cord-006860-a3b8hyyr	3559	1	*	*	NFP
cord-006860-a3b8hyyr	3559	2	Georg	Georg	NNP
cord-006860-a3b8hyyr	3559	3	-	-	HYPH
cord-006860-a3b8hyyr	3559	4	Augast	Augast	NNP
cord-006860-a3b8hyyr	3559	5	-	-	HYPH
cord-006860-a3b8hyyr	3559	6	Universit	Universit	NNP
cord-006860-a3b8hyyr	3559	7	/	/	SYM
cord-006860-a3b8hyyr	3559	8	itskinderidinik	itskinderidinik	NNP
cord-006860-a3b8hyyr	3559	9	,	,	,
cord-006860-a3b8hyyr	3559	10	G/3ttingen	G/3ttingen	NNP
cord-006860-a3b8hyyr	3559	11	,	,	,
cord-006860-a3b8hyyr	3559	12	Germany	Germany	NNP
cord-006860-a3b8hyyr	3559	13	Venous	venous	JJ
cord-006860-a3b8hyyr	3559	14	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3559	15	as	as	RB
cord-006860-a3b8hyyr	3559	16	well	well	RB
cord-006860-a3b8hyyr	3559	17	as	as	IN
cord-006860-a3b8hyyr	3560	1	arterial	arterial	JJ
cord-006860-a3b8hyyr	3560	2	thrombo	thrombo	JJ
cord-006860-a3b8hyyr	3560	3	-	-	HYPH
cord-006860-a3b8hyyr	3560	4	occlusive	occlusive	JJ
cord-006860-a3b8hyyr	3560	5	events	event	NNS
cord-006860-a3b8hyyr	3560	6	are	be	VBP
cord-006860-a3b8hyyr	3560	7	rarely	rarely	RB
cord-006860-a3b8hyyr	3560	8	observed	observe	VBN
cord-006860-a3b8hyyr	3560	9	in	in	IN
cord-006860-a3b8hyyr	3560	10	childhood	childhood	NN
cord-006860-a3b8hyyr	3560	11	,	,	,
cord-006860-a3b8hyyr	3560	12	but	but	CC
cord-006860-a3b8hyyr	3560	13	can	can	MD
cord-006860-a3b8hyyr	3560	14	lead	lead	VB
cord-006860-a3b8hyyr	3560	15	to	to	IN
cord-006860-a3b8hyyr	3560	16	life	life	NN
cord-006860-a3b8hyyr	3560	17	-	-	HYPH
cord-006860-a3b8hyyr	3560	18	threatening	threaten	VBG
cord-006860-a3b8hyyr	3560	19	situations	situation	NNS
cord-006860-a3b8hyyr	3560	20	and	and	CC
cord-006860-a3b8hyyr	3560	21	longterm	longterm	JJ
cord-006860-a3b8hyyr	3560	22	sequelae	sequela	NNS
cord-006860-a3b8hyyr	3560	23	in	in	IN
cord-006860-a3b8hyyr	3560	24	these	these	DT
cord-006860-a3b8hyyr	3560	25	Patients	patient	NNS
cord-006860-a3b8hyyr	3560	26	.	.	.
cord-006860-a3b8hyyr	3561	1	After	after	IN
cord-006860-a3b8hyyr	3561	2	the	the	DT
cord-006860-a3b8hyyr	3561	3	initial	initial	JJ
cord-006860-a3b8hyyr	3561	4	stage	stage	NN
cord-006860-a3b8hyyr	3561	5	of	of	IN
cord-006860-a3b8hyyr	3561	6	treatment	treatment	NN
cord-006860-a3b8hyyr	3561	7	(	(	-LRB-
cord-006860-a3b8hyyr	3561	8	thrembolysis	thrembolysis	NN
cord-006860-a3b8hyyr	3561	9	or	or	CC
cord-006860-a3b8hyyr	3561	10	thrombectomy	thrombectomy	NN
cord-006860-a3b8hyyr	3561	11	)	)	-RRB-
cord-006860-a3b8hyyr	3562	1	the	the	DT
cord-006860-a3b8hyyr	3562	2	pediatrician	pediatrician	NN
cord-006860-a3b8hyyr	3562	3	has	have	VBZ
cord-006860-a3b8hyyr	3562	4	to	to	TO
cord-006860-a3b8hyyr	3562	5	decide	decide	VB
cord-006860-a3b8hyyr	3562	6	how	how	WRB
cord-006860-a3b8hyyr	3562	7	to	to	TO
cord-006860-a3b8hyyr	3562	8	efficiently	efficiently	RB
cord-006860-a3b8hyyr	3562	9	prevent	prevent	VB
cord-006860-a3b8hyyr	3562	10	re	re	NN
cord-006860-a3b8hyyr	3562	11	-	-	NN
cord-006860-a3b8hyyr	3562	12	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3562	13	in	in	IN
cord-006860-a3b8hyyr	3562	14	the	the	DT
cord-006860-a3b8hyyr	3562	15	individual	individual	JJ
cord-006860-a3b8hyyr	3562	16	patient	patient	NN
cord-006860-a3b8hyyr	3562	17	.	.	.
cord-006860-a3b8hyyr	3563	1	Anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3563	2	after	after	IN
cord-006860-a3b8hyyr	3563	3	venous	venous	JJ
cord-006860-a3b8hyyr	3563	4	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3563	5	is	be	VBZ
cord-006860-a3b8hyyr	3563	6	generaUy	generaUy	NNP
cord-006860-a3b8hyyr	3563	7	recommended	recommend	VBN
cord-006860-a3b8hyyr	3563	8	for	for	IN
cord-006860-a3b8hyyr	3563	9	6	6	CD
cord-006860-a3b8hyyr	3563	10	months	month	NNS
cord-006860-a3b8hyyr	3563	11	after	after	IN
cord-006860-a3b8hyyr	3563	12	the	the	DT
cord-006860-a3b8hyyr	3563	13	event	event	NN
cord-006860-a3b8hyyr	3563	14	;	;	:
cord-006860-a3b8hyyr	3563	15	if	if	IN
cord-006860-a3b8hyyr	3563	16	an	an	DT
cord-006860-a3b8hyyr	3563	17	underlying	underlie	VBG
cord-006860-a3b8hyyr	3563	18	thrombophilic	thrombophilic	JJ
cord-006860-a3b8hyyr	3563	19	condition	condition	NN
cord-006860-a3b8hyyr	3563	20	has	have	VBZ
cord-006860-a3b8hyyr	3563	21	been	be	VBN
cord-006860-a3b8hyyr	3563	22	detected	detect	VBN
cord-006860-a3b8hyyr	3563	23	in	in	IN
cord-006860-a3b8hyyr	3563	24	the	the	DT
cord-006860-a3b8hyyr	3563	25	patient	patient	JJ
cord-006860-a3b8hyyr	3563	26	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3563	27	has	have	VBZ
cord-006860-a3b8hyyr	3563	28	to	to	TO
cord-006860-a3b8hyyr	3563	29	be	be	VB
cord-006860-a3b8hyyr	3563	30	considered	consider	VBN
cord-006860-a3b8hyyr	3563	31	lifelong	lifelong	JJ
cord-006860-a3b8hyyr	3563	32	.	.	.
cord-006860-a3b8hyyr	3564	1	When	when	WRB
cord-006860-a3b8hyyr	3564	2	evaluating	evaluate	VBG
cord-006860-a3b8hyyr	3564	3	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	3564	4	therapies	therapy	NNS
cord-006860-a3b8hyyr	3564	5	for	for	IN
cord-006860-a3b8hyyr	3564	6	children	child	NNS
cord-006860-a3b8hyyr	3564	7	it	-PRON-	PRP
cord-006860-a3b8hyyr	3564	8	is	be	VBZ
cord-006860-a3b8hyyr	3564	9	of	of	IN
cord-006860-a3b8hyyr	3564	10	importance	importance	NN
cord-006860-a3b8hyyr	3564	11	to	to	TO
cord-006860-a3b8hyyr	3564	12	consider	consider	VB
cord-006860-a3b8hyyr	3564	13	whether	whether	IN
cord-006860-a3b8hyyr	3564	14	the	the	DT
cord-006860-a3b8hyyr	3564	15	anticoagulatory	anticoagulatory	NN
cord-006860-a3b8hyyr	3564	16	effect	effect	NN
cord-006860-a3b8hyyr	3564	17	is	be	VBZ
cord-006860-a3b8hyyr	3564	18	mainly	mainly	RB
cord-006860-a3b8hyyr	3564	19	necessary	necessary	JJ
cord-006860-a3b8hyyr	3564	20	in	in	IN
cord-006860-a3b8hyyr	3564	21	the	the	DT
cord-006860-a3b8hyyr	3564	22	venous	venous	JJ
cord-006860-a3b8hyyr	3564	23	or	or	CC
cord-006860-a3b8hyyr	3564	24	arterial	arterial	JJ
cord-006860-a3b8hyyr	3564	25	vessel	vessel	NN
cord-006860-a3b8hyyr	3564	26	system	system	NN
cord-006860-a3b8hyyr	3564	27	.	.	.
cord-006860-a3b8hyyr	3565	1	The	the	DT
cord-006860-a3b8hyyr	3565	2	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	3565	3	risk	risk	NN
cord-006860-a3b8hyyr	3565	4	and	and	CC
cord-006860-a3b8hyyr	3565	5	side	side	NN
cord-006860-a3b8hyyr	3565	6	effects	effect	NNS
cord-006860-a3b8hyyr	3565	7	of	of	IN
cord-006860-a3b8hyyr	3565	8	the	the	DT
cord-006860-a3b8hyyr	3565	9	different	different	JJ
cord-006860-a3b8hyyr	3565	10	anticoagulatory	anticoagulatory	NN
cord-006860-a3b8hyyr	3565	11	preparations	preparation	NNS
cord-006860-a3b8hyyr	3565	12	have	have	VBP
cord-006860-a3b8hyyr	3565	13	to	to	TO
cord-006860-a3b8hyyr	3565	14	be	be	VB
cord-006860-a3b8hyyr	3565	15	taken	take	VBN
cord-006860-a3b8hyyr	3565	16	into	into	IN
cord-006860-a3b8hyyr	3565	17	account	account	NN
cord-006860-a3b8hyyr	3565	18	,	,	,
cord-006860-a3b8hyyr	3565	19	especially	especially	RB
cord-006860-a3b8hyyr	3565	20	when	when	WRB
cord-006860-a3b8hyyr	3565	21	treating	treat	VBG
cord-006860-a3b8hyyr	3565	22	small	small	JJ
cord-006860-a3b8hyyr	3565	23	children	child	NNS
cord-006860-a3b8hyyr	3565	24	.	.	.
cord-006860-a3b8hyyr	3566	1	Only	only	RB
cord-006860-a3b8hyyr	3566	2	limited	limited	JJ
cord-006860-a3b8hyyr	3566	3	experiences	experience	NNS
cord-006860-a3b8hyyr	3566	4	exist	exist	VBP
cord-006860-a3b8hyyr	3566	5	concerning	concern	VBG
cord-006860-a3b8hyyr	3566	6	the	the	DT
cord-006860-a3b8hyyr	3566	7	suitability	suitability	NN
cord-006860-a3b8hyyr	3566	8	of	of	IN
cord-006860-a3b8hyyr	3566	9	the	the	DT
cord-006860-a3b8hyyr	3566	10	preparations	preparation	NNS
cord-006860-a3b8hyyr	3566	11	for	for	IN
cord-006860-a3b8hyyr	3566	12	long	long	JJ
cord-006860-a3b8hyyr	3566	13	-	-	HYPH
cord-006860-a3b8hyyr	3566	14	term	term	NN
cord-006860-a3b8hyyr	3566	15	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3566	16	in	in	IN
cord-006860-a3b8hyyr	3566	17	children	child	NNS
cord-006860-a3b8hyyr	3566	18	and	and	CC
cord-006860-a3b8hyyr	3566	19	general	general	JJ
cord-006860-a3b8hyyr	3566	20	recommendations	recommendation	NNS
cord-006860-a3b8hyyr	3566	21	on	on	IN
cord-006860-a3b8hyyr	3566	22	the	the	DT
cord-006860-a3b8hyyr	3566	23	ideal	ideal	JJ
cord-006860-a3b8hyyr	3566	24	dosage	dosage	NN
cord-006860-a3b8hyyr	3566	25	in	in	IN
cord-006860-a3b8hyyr	3566	26	pediatric	pediatric	JJ
cord-006860-a3b8hyyr	3566	27	patients	patient	NNS
cord-006860-a3b8hyyr	3566	28	are	be	VBP
cord-006860-a3b8hyyr	3566	29	still	still	RB
cord-006860-a3b8hyyr	3566	30	missing	miss	VBG
cord-006860-a3b8hyyr	3566	31	.	.	.
cord-006860-a3b8hyyr	3567	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3567	2	want	want	VBP
cord-006860-a3b8hyyr	3567	3	to	to	TO
cord-006860-a3b8hyyr	3567	4	disscuss	disscuss	VB
cord-006860-a3b8hyyr	3567	5	different	different	JJ
cord-006860-a3b8hyyr	3567	6	types	type	NNS
cord-006860-a3b8hyyr	3567	7	of	of	IN
cord-006860-a3b8hyyr	3567	8	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	3567	9	(	(	-LRB-
cord-006860-a3b8hyyr	3567	10	such	such	JJ
cord-006860-a3b8hyyr	3567	11	as	as	IN
cord-006860-a3b8hyyr	3567	12	coumarins	coumarin	NNS
cord-006860-a3b8hyyr	3567	13	,	,	,
cord-006860-a3b8hyyr	3567	14	unfractionated	unfractionate	VBN
cord-006860-a3b8hyyr	3567	15	heparin	heparin	NNP
cord-006860-a3b8hyyr	3567	16	,	,	,
cord-006860-a3b8hyyr	3567	17	low	low	JJ
cord-006860-a3b8hyyr	3567	18	molecular	molecular	JJ
cord-006860-a3b8hyyr	3567	19	weight	weight	NN
cord-006860-a3b8hyyr	3567	20	heparin	heparin	NN
cord-006860-a3b8hyyr	3567	21	(	(	-LRB-
cord-006860-a3b8hyyr	3567	22	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	3567	23	)	)	-RRB-
cord-006860-a3b8hyyr	3567	24	and	and	CC
cord-006860-a3b8hyyr	3567	25	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3567	26	of	of	IN
cord-006860-a3b8hyyr	3567	27	platelet	platelet	NN
cord-006860-a3b8hyyr	3567	28	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3567	29	)	)	-RRB-
cord-006860-a3b8hyyr	3567	30	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3567	31	mode	mode	NN
cord-006860-a3b8hyyr	3567	32	of	of	IN
cord-006860-a3b8hyyr	3567	33	action	action	NN
cord-006860-a3b8hyyr	3567	34	,	,	,
cord-006860-a3b8hyyr	3567	35	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3567	36	suitability	suitability	NN
cord-006860-a3b8hyyr	3567	37	for	for	IN
cord-006860-a3b8hyyr	3567	38	pediatric	pediatric	JJ
cord-006860-a3b8hyyr	3567	39	patients	patient	NNS
cord-006860-a3b8hyyr	3567	40	and	and	CC
cord-006860-a3b8hyyr	3567	41	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3567	42	side	side	NN
cord-006860-a3b8hyyr	3567	43	effects	effect	NNS
cord-006860-a3b8hyyr	3567	44	and	and	CC
cord-006860-a3b8hyyr	3567	45	relevance	relevance	NN
cord-006860-a3b8hyyr	3567	46	of	of	IN
cord-006860-a3b8hyyr	3567	47	these	these	DT
cord-006860-a3b8hyyr	3567	48	side	side	NN
cord-006860-a3b8hyyr	3567	49	effects	effect	NNS
cord-006860-a3b8hyyr	3567	50	especially	especially	RB
cord-006860-a3b8hyyr	3567	51	in	in	IN
cord-006860-a3b8hyyr	3567	52	children	child	NNS
cord-006860-a3b8hyyr	3567	53	.	.	.
cord-006860-a3b8hyyr	3568	1	From	from	IN
cord-006860-a3b8hyyr	3568	2	the	the	DT
cord-006860-a3b8hyyr	3568	3	experience	experience	NN
cord-006860-a3b8hyyr	3568	4	in	in	IN
cord-006860-a3b8hyyr	3568	5	our	-PRON-	PRP$
cord-006860-a3b8hyyr	3568	6	own	own	JJ
cord-006860-a3b8hyyr	3568	7	pediatric	pediatric	JJ
cord-006860-a3b8hyyr	3568	8	patients	patient	NNS
cord-006860-a3b8hyyr	3568	9	,	,	,
cord-006860-a3b8hyyr	3568	10	we	-PRON-	PRP
cord-006860-a3b8hyyr	3568	11	would	would	MD
cord-006860-a3b8hyyr	3568	12	like	like	VB
cord-006860-a3b8hyyr	3568	13	to	to	TO
cord-006860-a3b8hyyr	3568	14	report	report	VB
cord-006860-a3b8hyyr	3568	15	on	on	IN
cord-006860-a3b8hyyr	3568	16	the	the	DT
cord-006860-a3b8hyyr	3568	17	indications	indication	NNS
cord-006860-a3b8hyyr	3568	18	,	,	,
cord-006860-a3b8hyyr	3568	19	which	which	WDT
cord-006860-a3b8hyyr	3568	20	can	can	MD
cord-006860-a3b8hyyr	3568	21	be	be	VB
cord-006860-a3b8hyyr	3568	22	given	give	VBN
cord-006860-a3b8hyyr	3568	23	to	to	TO
cord-006860-a3b8hyyr	3568	24	administer	administer	VB
cord-006860-a3b8hyyr	3568	25	these	these	DT
cord-006860-a3b8hyyr	3568	26	different	different	JJ
cord-006860-a3b8hyyr	3568	27	preparations	preparation	NNS
cord-006860-a3b8hyyr	3568	28	,	,	,
cord-006860-a3b8hyyr	3568	29	the	the	DT
cord-006860-a3b8hyyr	3568	30	dosage	dosage	NN
cord-006860-a3b8hyyr	3568	31	regimen	regimen	NN
cord-006860-a3b8hyyr	3568	32	we	-PRON-	PRP
cord-006860-a3b8hyyr	3568	33	recommend	recommend	VBP
cord-006860-a3b8hyyr	3568	34	and	and	CC
cord-006860-a3b8hyyr	3568	35	the	the	DT
cord-006860-a3b8hyyr	3568	36	Laboratory	Laboratory	NNP
cord-006860-a3b8hyyr	3568	37	tests	test	NNS
cord-006860-a3b8hyyr	3568	38	to	to	TO
cord-006860-a3b8hyyr	3568	39	monitor	monitor	VB
cord-006860-a3b8hyyr	3568	40	save	save	NN
cord-006860-a3b8hyyr	3568	41	and	and	CC
cord-006860-a3b8hyyr	3568	42	efficient	efficient	JJ
cord-006860-a3b8hyyr	3568	43	re	re	NN
cord-006860-a3b8hyyr	3568	44	-	-	NN
cord-006860-a3b8hyyr	3568	45	occlusion	occlusion	JJ
cord-006860-a3b8hyyr	3568	46	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	3568	47	in	in	IN
cord-006860-a3b8hyyr	3568	48	our	-PRON-	PRP$
cord-006860-a3b8hyyr	3568	49	patients	patient	NNS
cord-006860-a3b8hyyr	3568	50	.	.	.
cord-006860-a3b8hyyr	3569	1	In	in	IN
cord-006860-a3b8hyyr	3569	2	this	this	DT
cord-006860-a3b8hyyr	3569	3	context	context	NN
cord-006860-a3b8hyyr	3569	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	3569	5	would	would	MD
cord-006860-a3b8hyyr	3569	6	like	like	VB
cord-006860-a3b8hyyr	3569	7	to	to	TO
cord-006860-a3b8hyyr	3569	8	present	present	VB
cord-006860-a3b8hyyr	3569	9	our	-PRON-	PRP$
cord-006860-a3b8hyyr	3569	10	data	datum	NNS
cord-006860-a3b8hyyr	3569	11	on	on	IN
cord-006860-a3b8hyyr	3569	12	8	8	CD
cord-006860-a3b8hyyr	3569	13	patients	patient	NNS
cord-006860-a3b8hyyr	3569	14	with	with	IN
cord-006860-a3b8hyyr	3569	15	either	either	CC
cord-006860-a3b8hyyr	3569	16	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3569	17	or	or	CC
cord-006860-a3b8hyyr	3569	18	arterial	arterial	JJ
cord-006860-a3b8hyyr	3569	19	infarction	infarction	NN
cord-006860-a3b8hyyr	3569	20	due	due	IN
cord-006860-a3b8hyyr	3569	21	to	to	IN
cord-006860-a3b8hyyr	3569	22	a	a	DT
cord-006860-a3b8hyyr	3569	23	thrombophilic	thrombophilic	JJ
cord-006860-a3b8hyyr	3569	24	condition	condition	NN
cord-006860-a3b8hyyr	3569	25	,	,	,
cord-006860-a3b8hyyr	3569	26	who	who	WP
cord-006860-a3b8hyyr	3569	27	had	have	VBD
cord-006860-a3b8hyyr	3569	28	all	all	DT
cord-006860-a3b8hyyr	3569	29	contraindicatioas	contraindicatioas	NN
cord-006860-a3b8hyyr	3569	30	to	to	IN
cord-006860-a3b8hyyr	3569	31	oral	oral	JJ
cord-006860-a3b8hyyr	3569	32	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3569	33	by	by	IN
cord-006860-a3b8hyyr	3569	34	coumarins	coumarin	NNS
cord-006860-a3b8hyyr	3569	35	.	.	.
cord-006860-a3b8hyyr	3570	1	Because	because	IN
cord-006860-a3b8hyyr	3570	2	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	3570	3	for	for	IN
cord-006860-a3b8hyyr	3570	4	re	re	NN
cord-006860-a3b8hyyr	3570	5	-	-	NN
cord-006860-a3b8hyyr	3570	6	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3570	7	was	be	VBD
cord-006860-a3b8hyyr	3570	8	mandatory	mandatory	JJ
cord-006860-a3b8hyyr	3570	9	in	in	IN
cord-006860-a3b8hyyr	3570	10	these	these	DT
cord-006860-a3b8hyyr	3570	11	patients	patient	NNS
cord-006860-a3b8hyyr	3570	12	,	,	,
cord-006860-a3b8hyyr	3570	13	LMWH	LMWH	NNP
cord-006860-a3b8hyyr	3570	14	was	be	VBD
cord-006860-a3b8hyyr	3570	15	given	give	VBN
cord-006860-a3b8hyyr	3570	16	for	for	IN
cord-006860-a3b8hyyr	3570	17	long	long	JJ
cord-006860-a3b8hyyr	3570	18	-	-	HYPH
cord-006860-a3b8hyyr	3570	19	term	term	NN
cord-006860-a3b8hyyr	3570	20	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3570	21	in	in	IN
cord-006860-a3b8hyyr	3570	22	a	a	DT
cord-006860-a3b8hyyr	3570	23	dally	dally	NN
cord-006860-a3b8hyyr	3570	24	subcutaneous	subcutaneous	JJ
cord-006860-a3b8hyyr	3570	25	dosage	dosage	NN
cord-006860-a3b8hyyr	3570	26	of	of	IN
cord-006860-a3b8hyyr	3570	27	100	100	CD
cord-006860-a3b8hyyr	3570	28	-	-	SYM
cord-006860-a3b8hyyr	3570	29	150	150	CD
cord-006860-a3b8hyyr	3570	30	anti	anti	JJ
cord-006860-a3b8hyyr	3570	31	-	-	JJ
cord-006860-a3b8hyyr	3570	32	Xa	Xa	NNP
cord-006860-a3b8hyyr	3570	33	U	U	NNP
cord-006860-a3b8hyyr	3570	34	/	/	SYM
cord-006860-a3b8hyyr	3570	35	kgbw	kgbw	NNP
cord-006860-a3b8hyyr	3570	36	.	.	.
cord-006860-a3b8hyyr	3571	1	Monitoring	monitoring	NN
cord-006860-a3b8hyyr	3571	2	was	be	VBD
cord-006860-a3b8hyyr	3571	3	done	do	VBN
cord-006860-a3b8hyyr	3571	4	by	by	IN
cord-006860-a3b8hyyr	3571	5	Anti	Anti	NNP
cord-006860-a3b8hyyr	3571	6	-	-	NNP
cord-006860-a3b8hyyr	3571	7	Xa	Xa	NNP
cord-006860-a3b8hyyr	3571	8	-	-	HYPH
cord-006860-a3b8hyyr	3571	9	test	test	NN
cord-006860-a3b8hyyr	3571	10	(	(	-LRB-
cord-006860-a3b8hyyr	3571	11	0,4	0,4	CD
cord-006860-a3b8hyyr	3571	12	-	-	HYPH
cord-006860-a3b8hyyr	3571	13	0,8	0,8	CD
cord-006860-a3b8hyyr	3571	14	anti	anti	JJ
cord-006860-a3b8hyyr	3571	15	-	-	JJ
cord-006860-a3b8hyyr	3571	16	Xa	Xa	NNP
cord-006860-a3b8hyyr	3571	17	U	U	NNP
cord-006860-a3b8hyyr	3571	18	/	/	SYM
cord-006860-a3b8hyyr	3571	19	ml	ml	NN
cord-006860-a3b8hyyr	3571	20	)	)	-RRB-
cord-006860-a3b8hyyr	3571	21	.	.	.
cord-006860-a3b8hyyr	3572	1	Under	under	IN
cord-006860-a3b8hyyr	3572	2	this	this	DT
cord-006860-a3b8hyyr	3572	3	regimen	regimen	NN
cord-006860-a3b8hyyr	3572	4	none	none	NN
cord-006860-a3b8hyyr	3572	5	of	of	IN
cord-006860-a3b8hyyr	3572	6	the	the	DT
cord-006860-a3b8hyyr	3572	7	patients	patient	NNS
cord-006860-a3b8hyyr	3572	8	developed	develop	VBN
cord-006860-a3b8hyyr	3572	9	re	re	NN
cord-006860-a3b8hyyr	3572	10	-	-	NN
cord-006860-a3b8hyyr	3572	11	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3572	12	or	or	CC
cord-006860-a3b8hyyr	3572	13	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3572	14	complications	complication	NNS
cord-006860-a3b8hyyr	3572	15	.	.	.
cord-006860-a3b8hyyr	3573	1	Alopecia	Alopecia	NNP
cord-006860-a3b8hyyr	3573	2	was	be	VBD
cord-006860-a3b8hyyr	3573	3	seen	see	VBN
cord-006860-a3b8hyyr	3573	4	as	as	IN
cord-006860-a3b8hyyr	3573	5	a	a	DT
cord-006860-a3b8hyyr	3573	6	side	side	NN
cord-006860-a3b8hyyr	3573	7	-	-	HYPH
cord-006860-a3b8hyyr	3573	8	effect	effect	NN
cord-006860-a3b8hyyr	3573	9	.	.	.
cord-006860-a3b8hyyr	3574	1	This	this	DT
cord-006860-a3b8hyyr	3574	2	study	study	NN
cord-006860-a3b8hyyr	3574	3	was	be	VBD
cord-006860-a3b8hyyr	3574	4	designed	design	VBN
cord-006860-a3b8hyyr	3574	5	to	to	TO
cord-006860-a3b8hyyr	3574	6	prospectively	prospectively	RB
cord-006860-a3b8hyyr	3574	7	evaluate	evaluate	VB
cord-006860-a3b8hyyr	3574	8	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3574	9	and	and	CC
cord-006860-a3b8hyyr	3574	10	fihrinolytic	fihrinolytic	JJ
cord-006860-a3b8hyyr	3574	11	activation	activation	NN
cord-006860-a3b8hyyr	3574	12	after	after	IN
cord-006860-a3b8hyyr	3574	13	cardiopulmonary	cardiopulmonary	JJ
cord-006860-a3b8hyyr	3574	14	bypass	bypass	NN
cord-006860-a3b8hyyr	3574	15	with	with	IN
cord-006860-a3b8hyyr	3574	16	aprotinin	aprotinin	NNS
cord-006860-a3b8hyyr	3574	17	(	(	-LRB-
cord-006860-a3b8hyyr	3574	18	2x17000	2x17000	CD
cord-006860-a3b8hyyr	3575	1	U	U	NNP
cord-006860-a3b8hyyr	3575	2	/	/	SYM
cord-006860-a3b8hyyr	3575	3	kg	kg	NNP
cord-006860-a3b8hyyr	3575	4	bw	bw	NNP
cord-006860-a3b8hyyr	3575	5	)	)	-RRB-
cord-006860-a3b8hyyr	3575	6	in	in	IN
cord-006860-a3b8hyyr	3575	7	42	42	CD
cord-006860-a3b8hyyr	3575	8	infants	infant	NNS
cord-006860-a3b8hyyr	3575	9	and	and	CC
cord-006860-a3b8hyyr	3575	10	children	child	NNS
cord-006860-a3b8hyyr	3575	11	aged	age	VBN
cord-006860-a3b8hyyr	3575	12	0.1	0.1	CD
cord-006860-a3b8hyyr	3575	13	-15	-15	CD
cord-006860-a3b8hyyr	3575	14	years	year	NNS
cord-006860-a3b8hyyr	3575	15	,	,	,
cord-006860-a3b8hyyr	3575	16	and	and	CC
cord-006860-a3b8hyyr	3575	17	to	to	TO
cord-006860-a3b8hyyr	3575	18	correlate	correlate	VB
cord-006860-a3b8hyyr	3575	19	these	these	DT
cord-006860-a3b8hyyr	3575	20	findings	finding	NNS
cord-006860-a3b8hyyr	3575	21	to	to	IN
cord-006860-a3b8hyyr	3575	22	the	the	DT
cord-006860-a3b8hyyr	3575	23	clinical	clinical	JJ
cord-006860-a3b8hyyr	3575	24	outcome	outcome	NN
cord-006860-a3b8hyyr	3575	25	.	.	.
cord-006860-a3b8hyyr	3576	1	Prothrombin	Prothrombin	NNP
cord-006860-a3b8hyyr	3576	2	fragment	fragment	NN
cord-006860-a3b8hyyr	3576	3	F	F	NNP
cord-006860-a3b8hyyr	3576	4	1.2	1.2	CD
cord-006860-a3b8hyyr	3576	5	(	(	-LRB-
cord-006860-a3b8hyyr	3576	6	F1.2	F1.2	NNP
cord-006860-a3b8hyyr	3576	7	;	;	:
cord-006860-a3b8hyyr	3576	8	Behring	Behring	NNP
cord-006860-a3b8hyyr	3576	9	Werke	Werke	NNP
cord-006860-a3b8hyyr	3576	10	Marburg	Marburg	NNP
cord-006860-a3b8hyyr	3576	11	:	:	:
cord-006860-a3b8hyyr	3577	1	nmol	nmol	NNP
cord-006860-a3b8hyyr	3577	2	/	/	SYM
cord-006860-a3b8hyyr	3577	3	l	l	NNP
cord-006860-a3b8hyyr	3577	4	)	)	-RRB-
cord-006860-a3b8hyyr	3577	5	,	,	,
cord-006860-a3b8hyyr	3577	6	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3577	7	-	-	HYPH
cord-006860-a3b8hyyr	3577	8	serinesterase	serinesterase	NNP
cord-006860-a3b8hyyr	3578	1	-complex	-complex	.
cord-006860-a3b8hyyr	3579	1	(	(	-LRB-
cord-006860-a3b8hyyr	3579	2	ATM	ATM	NNP
cord-006860-a3b8hyyr	3579	3	;	;	:
cord-006860-a3b8hyyr	3579	4	Stago	Stago	NNP
cord-006860-a3b8hyyr	3579	5	:	:	:
cord-006860-a3b8hyyr	3579	6	ng	ng	NNP
cord-006860-a3b8hyyr	3579	7	/	/	SYM
cord-006860-a3b8hyyr	3579	8	ml	ml	NNP
cord-006860-a3b8hyyr	3579	9	)	)	-RRB-
cord-006860-a3b8hyyr	3579	10	,	,	.
cord-006860-a3b8hyyr	3580	1	D	D	NNP
cord-006860-a3b8hyyr	3580	2	-Dimer	-Dimer	NNP
cord-006860-a3b8hyyr	3580	3	formation	formation	NN
cord-006860-a3b8hyyr	3580	4	(	(	-LRB-
cord-006860-a3b8hyyr	3580	5	D	D	NNP
cord-006860-a3b8hyyr	3580	6	-	-	HYPH
cord-006860-a3b8hyyr	3580	7	D	d	JJ
cord-006860-a3b8hyyr	3580	8	;	;	:
cord-006860-a3b8hyyr	3580	9	Behring	Behring	NNP
cord-006860-a3b8hyyr	3580	10	Werke	Werke	NNP
cord-006860-a3b8hyyr	3580	11	Marburg	Marburg	NNP
cord-006860-a3b8hyyr	3580	12	:	:	:
cord-006860-a3b8hyyr	3580	13	ug	ug	NNP
cord-006860-a3b8hyyr	3580	14	/	/	SYM
cord-006860-a3b8hyyr	3580	15	l	l	NNP
cord-006860-a3b8hyyr	3580	16	)	)	-RRB-
cord-006860-a3b8hyyr	3580	17	,	,	,
cord-006860-a3b8hyyr	3580	18	tissue	tissue	NN
cord-006860-a3b8hyyr	3580	19	-	-	HYPH
cord-006860-a3b8hyyr	3580	20	type	type	NN
cord-006860-a3b8hyyr	3580	21	-	-	HYPH
cord-006860-a3b8hyyr	3580	22	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	3580	23	activator	activator	NN
cord-006860-a3b8hyyr	3580	24	ag	ag	NNP
cord-006860-a3b8hyyr	3580	25	(	(	-LRB-
cord-006860-a3b8hyyr	3580	26	t	t	NNP
cord-006860-a3b8hyyr	3580	27	-	-	HYPH
cord-006860-a3b8hyyr	3580	28	PA	PA	NNP
cord-006860-a3b8hyyr	3580	29	;	;	:
cord-006860-a3b8hyyr	3581	1	Chromogenix	Chromogenix	NNP
cord-006860-a3b8hyyr	3581	2	:	:	:
cord-006860-a3b8hyyr	3581	3	ng	ng	NNP
cord-006860-a3b8hyyr	3581	4	/	/	SYM
cord-006860-a3b8hyyr	3581	5	ml	ml	NNP
cord-006860-a3b8hyyr	3581	6	)	)	-RRB-
cord-006860-a3b8hyyr	3581	7	,	,	,
cord-006860-a3b8hyyr	3581	8	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	3581	9	activator	activator	NN
cord-006860-a3b8hyyr	3581	10	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3581	11	1	1	CD
cord-006860-a3b8hyyr	3581	12	antigen	antigen	NN
cord-006860-a3b8hyyr	3581	13	(	(	-LRB-
cord-006860-a3b8hyyr	3581	14	PAI	PAI	NNP
cord-006860-a3b8hyyr	3581	15	;	;	:
cord-006860-a3b8hyyr	3581	16	Chromogenix	Chromogenix	NNP
cord-006860-a3b8hyyr	3581	17	:	:	:
cord-006860-a3b8hyyr	3581	18	ng	ng	NNP
cord-006860-a3b8hyyr	3581	19	/	/	SYM
cord-006860-a3b8hyyr	3581	20	ml	ml	NNP
cord-006860-a3b8hyyr	3581	21	)	)	-RRB-
cord-006860-a3b8hyyr	3581	22	and	and	CC
cord-006860-a3b8hyyr	3581	23	Cl	Cl	NNP
cord-006860-a3b8hyyr	3581	24	-	-	HYPH
cord-006860-a3b8hyyr	3581	25	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3581	26	(	(	-LRB-
cord-006860-a3b8hyyr	3581	27	C1	C1	NNP
cord-006860-a3b8hyyr	3581	28	;	;	:
cord-006860-a3b8hyyr	3581	29	Behring	Behring	NNP
cord-006860-a3b8hyyr	3581	30	Werke	Werke	NNP
cord-006860-a3b8hyyr	3581	31	Marburg	Marburg	NNP
cord-006860-a3b8hyyr	3581	32	:	:	:
cord-006860-a3b8hyyr	3581	33	x	x	SYM
cord-006860-a3b8hyyr	3581	34	10	10	CD
cord-006860-a3b8hyyr	3581	35	-	-	SYM
cord-006860-a3b8hyyr	3581	36	3	3	CD
cord-006860-a3b8hyyr	3581	37	g	g	NN
cord-006860-a3b8hyyr	3581	38	/	/	SYM
cord-006860-a3b8hyyr	3581	39	l	l	NN
cord-006860-a3b8hyyr	3581	40	)	)	-RRB-
cord-006860-a3b8hyyr	3581	41	were	be	VBD
cord-006860-a3b8hyyr	3581	42	investigated	investigate	VBN
cord-006860-a3b8hyyr	3581	43	before	before	IN
cord-006860-a3b8hyyr	3581	44	the	the	DT
cord-006860-a3b8hyyr	3581	45	operation	operation	NN
cord-006860-a3b8hyyr	3581	46	(	(	-LRB-
cord-006860-a3b8hyyr	3581	47	T1	T1	NNP
cord-006860-a3b8hyyr	3581	48	)	)	-RRB-
cord-006860-a3b8hyyr	3581	49	,	,	,
cord-006860-a3b8hyyr	3581	50	at	at	IN
cord-006860-a3b8hyyr	3581	51	the	the	DT
cord-006860-a3b8hyyr	3581	52	end	end	NN
cord-006860-a3b8hyyr	3581	53	of	of	IN
cord-006860-a3b8hyyr	3581	54	the	the	DT
cord-006860-a3b8hyyr	3581	55	operation	operation	NN
cord-006860-a3b8hyyr	3581	56	(	(	-LRB-
cord-006860-a3b8hyyr	3581	57	T2	T2	NNP
cord-006860-a3b8hyyr	3581	58	)	)	-RRB-
cord-006860-a3b8hyyr	3581	59	,	,	,
cord-006860-a3b8hyyr	3581	60	and	and	CC
cord-006860-a3b8hyyr	3581	61	on	on	IN
cord-006860-a3b8hyyr	3581	62	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	3581	63	days	day	NNS
cord-006860-a3b8hyyr	3581	64	1	1	CD
cord-006860-a3b8hyyr	3581	65	(	(	-LRB-
cord-006860-a3b8hyyr	3581	66	T3	T3	NNP
cord-006860-a3b8hyyr	3581	67	)	)	-RRB-
cord-006860-a3b8hyyr	3581	68	,	,	,
cord-006860-a3b8hyyr	3581	69	4	4	CD
cord-006860-a3b8hyyr	3581	70	-	-	SYM
cord-006860-a3b8hyyr	3581	71	6	6	CD
cord-006860-a3b8hyyr	3581	72	(	(	-LRB-
cord-006860-a3b8hyyr	3581	73	T4	T4	NNP
cord-006860-a3b8hyyr	3581	74	)	)	-RRB-
cord-006860-a3b8hyyr	3581	75	and	and	CC
cord-006860-a3b8hyyr	3581	76	7	7	CD
cord-006860-a3b8hyyr	3581	77	-	-	SYM
cord-006860-a3b8hyyr	3581	78	9	9	CD
cord-006860-a3b8hyyr	3581	79	(	(	-LRB-
cord-006860-a3b8hyyr	3581	80	T5	T5	NNP
cord-006860-a3b8hyyr	3581	81	)	)	-RRB-
cord-006860-a3b8hyyr	3581	82	,	,	,
cord-006860-a3b8hyyr	3581	83	respectively	respectively	RB
cord-006860-a3b8hyyr	3581	84	.	.	.
cord-006860-a3b8hyyr	3582	1	The	the	DT
cord-006860-a3b8hyyr	3582	2	results	result	NNS
cord-006860-a3b8hyyr	3582	3	are	be	VBP
cord-006860-a3b8hyyr	3582	4	shown	show	VBN
cord-006860-a3b8hyyr	3582	5	in	in	IN
cord-006860-a3b8hyyr	3582	6	the	the	DT
cord-006860-a3b8hyyr	3582	7	table	table	NN
cord-006860-a3b8hyyr	3582	8	(	(	-LRB-
cord-006860-a3b8hyyr	3582	9	median	median	NN
cord-006860-a3b8hyyr	3582	10	and	and	CC
cord-006860-a3b8hyyr	3582	11	median	median	JJ
cord-006860-a3b8hyyr	3582	12	absolut	absolut	JJ
cord-006860-a3b8hyyr	3582	13	deviation	deviation	NN
cord-006860-a3b8hyyr	3582	14	)	)	-RRB-
cord-006860-a3b8hyyr	3582	15	:	:	:
cord-006860-a3b8hyyr	3583	1	T1	T1	NNP
cord-006860-a3b8hyyr	3583	2	T2	T2	NNP
cord-006860-a3b8hyyr	3583	3	T3	T3	NNP
cord-006860-a3b8hyyr	3583	4	T4	T4	NNP
cord-006860-a3b8hyyr	3583	5	"	"	''
cord-006860-a3b8hyyr	3583	6	1"5	1"5	CD
cord-006860-a3b8hyyr	3583	7	NV	NV	NNP
cord-006860-a3b8hyyr	3584	1	FI.2	fi.2	NN
cord-006860-a3b8hyyr	3584	2	0.9	0.9	CD
cord-006860-a3b8hyyr	3584	3	+	+	CD
cord-006860-a3b8hyyr	3585	1	/-0.5	/-0.5	.
cord-006860-a3b8hyyr	3586	1	1.7	1.7	CD
cord-006860-a3b8hyyr	3586	2	+	+	CC
cord-006860-a3b8hyyr	3587	1	/-0.9	/-0.9	.
cord-006860-a3b8hyyr	3588	1	1.4+/-1	1.4+/-1	CD
cord-006860-a3b8hyyr	3588	2	1.8+/-0.8	1.8+/-0.8	CD
cord-006860-a3b8hyyr	3588	3	1.6+/-0	1.6+/-0	CD
cord-006860-a3b8hyyr	3588	4	.	.	.
cord-006860-a3b8hyyr	3589	1	The	the	DT
cord-006860-a3b8hyyr	3589	2	platelet	platelet	NN
cord-006860-a3b8hyyr	3589	3	(	(	-LRB-
cord-006860-a3b8hyyr	3589	4	PL	pl	NN
cord-006860-a3b8hyyr	3589	5	)	)	-RRB-
cord-006860-a3b8hyyr	3589	6	function	function	NN
cord-006860-a3b8hyyr	3589	7	defect	defect	NN
cord-006860-a3b8hyyr	3589	8	induced	induce	VBN
cord-006860-a3b8hyyr	3589	9	by	by	IN
cord-006860-a3b8hyyr	3589	10	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	3589	11	agents	agent	NNS
cord-006860-a3b8hyyr	3589	12	has	have	VBZ
cord-006860-a3b8hyyr	3589	13	been	be	VBN
cord-006860-a3b8hyyr	3589	14	attributed	attribute	VBN
cord-006860-a3b8hyyr	3589	15	either	either	CC
cord-006860-a3b8hyyr	3589	16	to	to	IN
cord-006860-a3b8hyyr	3589	17	the	the	DT
cord-006860-a3b8hyyr	3589	18	degradation	degradation	NN
cord-006860-a3b8hyyr	3589	19	of	of	IN
cord-006860-a3b8hyyr	3589	20	PL	pl	NN
cord-006860-a3b8hyyr	3589	21	surface	surface	NN
cord-006860-a3b8hyyr	3589	22	receptors	receptor	NNS
cord-006860-a3b8hyyr	3589	23	or	or	CC
cord-006860-a3b8hyyr	3589	24	to	to	IN
cord-006860-a3b8hyyr	3589	25	the	the	DT
cord-006860-a3b8hyyr	3589	26	anti	anti	JJ
cord-006860-a3b8hyyr	3589	27	-	-	JJ
cord-006860-a3b8hyyr	3589	28	aggregatory	aggregatory	JJ
cord-006860-a3b8hyyr	3589	29	effect	effect	NN
cord-006860-a3b8hyyr	3589	30	of	of	IN
cord-006860-a3b8hyyr	3589	31	FgDPs	FgDPs	NNP
cord-006860-a3b8hyyr	3589	32	.	.	.
cord-006860-a3b8hyyr	3590	1	In	in	IN
cord-006860-a3b8hyyr	3590	2	contrast	contrast	NN
cord-006860-a3b8hyyr	3590	3	to	to	IN
cord-006860-a3b8hyyr	3590	4	other	other	JJ
cord-006860-a3b8hyyr	3590	5	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	3590	6	activators	activator	NNS
cord-006860-a3b8hyyr	3590	7	scu	scu	NNP
cord-006860-a3b8hyyr	3590	8	-	-	HYPH
cord-006860-a3b8hyyr	3590	9	PA	PA	NNP
cord-006860-a3b8hyyr	3590	10	is	be	VBZ
cord-006860-a3b8hyyr	3590	11	intimately	intimately	RB
cord-006860-a3b8hyyr	3590	12	Inked	ink	VBN
cord-006860-a3b8hyyr	3590	13	with	with	IN
cord-006860-a3b8hyyr	3590	14	PL	pl	NN
cord-006860-a3b8hyyr	3590	15	:	:	:
cord-006860-a3b8hyyr	3590	16	they	-PRON-	PRP
cord-006860-a3b8hyyr	3590	17	can	can	MD
cord-006860-a3b8hyyr	3590	18	rapidly	rapidly	RB
cord-006860-a3b8hyyr	3590	19	incorporate	incorporate	VB
cord-006860-a3b8hyyr	3590	20	exogenous	exogenous	JJ
cord-006860-a3b8hyyr	3590	21	seu	seu	NNP
cord-006860-a3b8hyyr	3590	22	-	-	HYPH
cord-006860-a3b8hyyr	3590	23	PA	PA	NNP
cord-006860-a3b8hyyr	3590	24	,	,	,
cord-006860-a3b8hyyr	3590	25	release	release	VB
cord-006860-a3b8hyyr	3590	26	it	-PRON-	PRP
cord-006860-a3b8hyyr	3590	27	upon	upon	IN
cord-006860-a3b8hyyr	3590	28	stimulation	stimulation	NN
cord-006860-a3b8hyyr	3590	29	and	and	CC
cord-006860-a3b8hyyr	3590	30	bind	bind	VB
cord-006860-a3b8hyyr	3590	31	the	the	DT
cord-006860-a3b8hyyr	3590	32	proenzyme	proenzyme	NNS
cord-006860-a3b8hyyr	3590	33	.	.	.
cord-006860-a3b8hyyr	3591	1	Recently	recently	RB
cord-006860-a3b8hyyr	3591	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	3591	3	have	have	VBP
cord-006860-a3b8hyyr	3591	4	reported	report	VBN
cord-006860-a3b8hyyr	3591	5	that	that	IN
cord-006860-a3b8hyyr	3591	6	exposure	exposure	NN
cord-006860-a3b8hyyr	3591	7	of	of	IN
cord-006860-a3b8hyyr	3591	8	PRP	PRP	NNP
cord-006860-a3b8hyyr	3591	9	to	to	IN
cord-006860-a3b8hyyr	3591	10	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	3591	11	scu	scu	NNP
cord-006860-a3b8hyyr	3591	12	-	-	HYPH
cord-006860-a3b8hyyr	3591	13	PA	PA	NNP
cord-006860-a3b8hyyr	3591	14	(	(	-LRB-
cord-006860-a3b8hyyr	3591	15	2.5-t00	2.5-t00	CD
cord-006860-a3b8hyyr	3591	16	uM	um	UH
cord-006860-a3b8hyyr	3591	17	)	)	-RRB-
cord-006860-a3b8hyyr	3591	18	in	in	IN
cord-006860-a3b8hyyr	3591	19	timed	time	VBN
cord-006860-a3b8hyyr	3591	20	interval	interval	NN
cord-006860-a3b8hyyr	3591	21	1	1	CD
cord-006860-a3b8hyyr	3591	22	-	-	SYM
cord-006860-a3b8hyyr	3591	23	30	30	CD
cord-006860-a3b8hyyr	3591	24	min	min	NN
cord-006860-a3b8hyyr	3591	25	resulted	result	VBD
cord-006860-a3b8hyyr	3591	26	in	in	IN
cord-006860-a3b8hyyr	3591	27	dose	dose	NN
cord-006860-a3b8hyyr	3591	28	-	-	HYPH
cord-006860-a3b8hyyr	3591	29	dependent	dependent	JJ
cord-006860-a3b8hyyr	3591	30	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3591	31	of	of	IN
cord-006860-a3b8hyyr	3591	32	PL	pl	NN
cord-006860-a3b8hyyr	3591	33	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3591	34	.	.	.
cord-006860-a3b8hyyr	3592	1	Timecourse	timecourse	NN
cord-006860-a3b8hyyr	3592	2	changes	change	NNS
cord-006860-a3b8hyyr	3592	3	of	of	IN
cord-006860-a3b8hyyr	3592	4	the	the	DT
cord-006860-a3b8hyyr	3592	5	process	process	NN
cord-006860-a3b8hyyr	3592	6	were	be	VBD
cord-006860-a3b8hyyr	3592	7	followed	follow	VBN
cord-006860-a3b8hyyr	3592	8	by	by	IN
cord-006860-a3b8hyyr	3592	9	the	the	DT
cord-006860-a3b8hyyr	3592	10	biexpotential	biexpotential	JJ
cord-006860-a3b8hyyr	3592	11	kinetics	kinetics	NNP
cord-006860-a3b8hyyr	3592	12	:	:	:
cord-006860-a3b8hyyr	3592	13	a	a	DT
cord-006860-a3b8hyyr	3592	14	rapid	rapid	JJ
cord-006860-a3b8hyyr	3592	15	initial	initial	JJ
cord-006860-a3b8hyyr	3592	16	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3592	17	during	during	IN
cord-006860-a3b8hyyr	3592	18	the	the	DT
cord-006860-a3b8hyyr	3592	19	first	first	JJ
cord-006860-a3b8hyyr	3592	20	3	3	CD
cord-006860-a3b8hyyr	3592	21	-	-	SYM
cord-006860-a3b8hyyr	3592	22	5	5	CD
cord-006860-a3b8hyyr	3592	23	rain	rain	NN
cord-006860-a3b8hyyr	3592	24	with	with	IN
cord-006860-a3b8hyyr	3592	25	the	the	DT
cord-006860-a3b8hyyr	3592	26	moderate	moderate	JJ
cord-006860-a3b8hyyr	3592	27	suppression	suppression	NN
cord-006860-a3b8hyyr	3592	28	of	of	IN
cord-006860-a3b8hyyr	3592	29	PL	pl	NN
cord-006860-a3b8hyyr	3592	30	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3592	31	in	in	IN
cord-006860-a3b8hyyr	3592	32	the	the	DT
cord-006860-a3b8hyyr	3592	33	30	30	CD
cord-006860-a3b8hyyr	3592	34	min	min	NN
cord-006860-a3b8hyyr	3592	35	period	period	NN
cord-006860-a3b8hyyr	3592	36	.	.	.
cord-006860-a3b8hyyr	3593	1	When	when	WRB
cord-006860-a3b8hyyr	3593	2	tcu	tcu	NNP
cord-006860-a3b8hyyr	3593	3	-	-	HYPH
cord-006860-a3b8hyyr	3593	4	PA	PA	NNP
cord-006860-a3b8hyyr	3593	5	(	(	-LRB-
cord-006860-a3b8hyyr	3593	6	25	25	CD
cord-006860-a3b8hyyr	3593	7	-	-	SYM
cord-006860-a3b8hyyr	3593	8	100	100	CD
cord-006860-a3b8hyyr	3593	9	nM	nm	NN
cord-006860-a3b8hyyr	3593	10	)	)	-RRB-
cord-006860-a3b8hyyr	3593	11	was	be	VBD
cord-006860-a3b8hyyr	3593	12	exposed	expose	VBN
cord-006860-a3b8hyyr	3593	13	to	to	IN
cord-006860-a3b8hyyr	3593	14	PRP	PRP	NNP
cord-006860-a3b8hyyr	3593	15	in	in	IN
cord-006860-a3b8hyyr	3593	16	the	the	DT
cord-006860-a3b8hyyr	3593	17	same	same	JJ
cord-006860-a3b8hyyr	3593	18	conditions	condition	NNS
cord-006860-a3b8hyyr	3593	19	dose	dose	NN
cord-006860-a3b8hyyr	3593	20	-	-	HYPH
cord-006860-a3b8hyyr	3593	21	and	and	CC
cord-006860-a3b8hyyr	3593	22	time	time	NN
cord-006860-a3b8hyyr	3593	23	-	-	HYPH
cord-006860-a3b8hyyr	3593	24	dependent	dependent	JJ
cord-006860-a3b8hyyr	3593	25	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3593	26	of	of	IN
cord-006860-a3b8hyyr	3593	27	PL	pl	NN
cord-006860-a3b8hyyr	3593	28	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3593	29	was	be	VBD
cord-006860-a3b8hyyr	3593	30	also	also	RB
cord-006860-a3b8hyyr	3593	31	observed	observe	VBN
cord-006860-a3b8hyyr	3593	32	.	.	.
cord-006860-a3b8hyyr	3594	1	Since	since	IN
cord-006860-a3b8hyyr	3594	2	the	the	DT
cord-006860-a3b8hyyr	3594	3	effect	effect	NN
cord-006860-a3b8hyyr	3594	4	was	be	VBD
cord-006860-a3b8hyyr	3594	5	obtained	obtain	VBN
cord-006860-a3b8hyyr	3594	6	no	no	DT
cord-006860-a3b8hyyr	3594	7	earlier	early	RBR
cord-006860-a3b8hyyr	3594	8	than	than	IN
cord-006860-a3b8hyyr	3594	9	t0	t0	NNP
cord-006860-a3b8hyyr	3594	10	min	min	NNP
cord-006860-a3b8hyyr	3594	11	after	after	IN
cord-006860-a3b8hyyr	3594	12	exposure	exposure	NN
cord-006860-a3b8hyyr	3594	13	of	of	IN
cord-006860-a3b8hyyr	3594	14	tcu	tcu	NNP
cord-006860-a3b8hyyr	3594	15	-	-	HYPH
cord-006860-a3b8hyyr	3594	16	PA	PA	NNP
cord-006860-a3b8hyyr	3594	17	to	to	IN
cord-006860-a3b8hyyr	3594	18	PRP	PRP	NNP
cord-006860-a3b8hyyr	3594	19	,	,	,
cord-006860-a3b8hyyr	3594	20	and	and	CC
cord-006860-a3b8hyyr	3594	21	the	the	DT
cord-006860-a3b8hyyr	3594	22	threshold	threshold	NN
cord-006860-a3b8hyyr	3594	23	dose	dose	NN
cord-006860-a3b8hyyr	3594	24	was	be	VBD
cord-006860-a3b8hyyr	3594	25	higher	high	JJR
cord-006860-a3b8hyyr	3594	26	.	.	.
cord-006860-a3b8hyyr	3595	1	Comparable	comparable	JJ
cord-006860-a3b8hyyr	3595	2	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3595	3	of	of	IN
cord-006860-a3b8hyyr	3595	4	PL	pl	NN
cord-006860-a3b8hyyr	3595	5	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3595	6	was	be	VBD
cord-006860-a3b8hyyr	3595	7	obtained	obtain	VBN
cord-006860-a3b8hyyr	3595	8	with	with	IN
cord-006860-a3b8hyyr	3595	9	25nM	25nm	CD
cord-006860-a3b8hyyr	3595	10	of	of	IN
cord-006860-a3b8hyyr	3595	11	scu	scu	NNP
cord-006860-a3b8hyyr	3595	12	-	-	HYPH
cord-006860-a3b8hyyr	3595	13	PA	PA	NNP
cord-006860-a3b8hyyr	3595	14	versus	versus	IN
cord-006860-a3b8hyyr	3595	15	100nM	100nm	CD
cord-006860-a3b8hyyr	3595	16	of	of	IN
cord-006860-a3b8hyyr	3595	17	tcu	tcu	NNP
cord-006860-a3b8hyyr	3595	18	-	-	HYPH
cord-006860-a3b8hyyr	3595	19	PA	PA	NNP
cord-006860-a3b8hyyr	3595	20	and	and	CC
cord-006860-a3b8hyyr	3595	21	the	the	DT
cord-006860-a3b8hyyr	3595	22	llbrinogen	llbrinogen	NNP
cord-006860-a3b8hyyr	3595	23	depletion	depletion	NN
cord-006860-a3b8hyyr	3595	24	by	by	IN
cord-006860-a3b8hyyr	3595	25	the	the	DT
cord-006860-a3b8hyyr	3595	26	end	end	NN
cord-006860-a3b8hyyr	3595	27	of	of	IN
cord-006860-a3b8hyyr	3595	28	the	the	DT
cord-006860-a3b8hyyr	3595	29	30	30	CD
cord-006860-a3b8hyyr	3595	30	min	min	NN
cord-006860-a3b8hyyr	3595	31	period	period	NN
cord-006860-a3b8hyyr	3595	32	was	be	VBD
cord-006860-a3b8hyyr	3595	33	2	2	CD
cord-006860-a3b8hyyr	3595	34	%	%	NN
cord-006860-a3b8hyyr	3595	35	and	and	CC
cord-006860-a3b8hyyr	3595	36	30	30	CD
cord-006860-a3b8hyyr	3595	37	%	%	NN
cord-006860-a3b8hyyr	3595	38	respectively	respectively	RB
cord-006860-a3b8hyyr	3595	39	.	.	.
cord-006860-a3b8hyyr	3596	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	3596	2	's	be	VBZ
cord-006860-a3b8hyyr	3596	3	likely	likely	JJ
cord-006860-a3b8hyyr	3596	4	that	that	IN
cord-006860-a3b8hyyr	3596	5	tcu	tcu	NNP
cord-006860-a3b8hyyr	3596	6	-	-	HYPH
cord-006860-a3b8hyyr	3596	7	PA	PA	NNP
cord-006860-a3b8hyyr	3596	8	and	and	CC
cord-006860-a3b8hyyr	3596	9	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3596	10	precursor	precursor	NN
cord-006860-a3b8hyyr	3596	11	have	have	VBP
cord-006860-a3b8hyyr	3596	12	different	different	JJ
cord-006860-a3b8hyyr	3596	13	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	3596	14	of	of	IN
cord-006860-a3b8hyyr	3596	15	action	action	NN
cord-006860-a3b8hyyr	3596	16	on	on	IN
cord-006860-a3b8hyyr	3596	17	the	the	DT
cord-006860-a3b8hyyr	3596	18	PL	PL	NNP
cord-006860-a3b8hyyr	3596	19	aggregatory	aggregatory	NN
cord-006860-a3b8hyyr	3596	20	function	function	NN
cord-006860-a3b8hyyr	3596	21	.	.	.
cord-006860-a3b8hyyr	3597	1	In	in	IN
cord-006860-a3b8hyyr	3597	2	a	a	DT
cord-006860-a3b8hyyr	3597	3	recent	recent	JJ
cord-006860-a3b8hyyr	3597	4	study	study	NN
cord-006860-a3b8hyyr	3597	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	3597	6	have	have	VBP
cord-006860-a3b8hyyr	3597	7	shown	show	VBN
cord-006860-a3b8hyyr	3597	8	that	that	IN
cord-006860-a3b8hyyr	3597	9	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	3597	10	rscu	rscu	NNP
cord-006860-a3b8hyyr	3597	11	-	-	HYPH
cord-006860-a3b8hyyr	3597	12	PA	PA	NNP
cord-006860-a3b8hyyr	3597	13	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	3597	14	platelet	platelet	NN
cord-006860-a3b8hyyr	3597	15	(	(	-LRB-
cord-006860-a3b8hyyr	3597	16	PL	pl	NN
cord-006860-a3b8hyyr	3597	17	)	)	-RRB-
cord-006860-a3b8hyyr	3597	18	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3597	19	in	in	IN
cord-006860-a3b8hyyr	3597	20	PRP	PRP	NNP
cord-006860-a3b8hyyr	3597	21	.	.	.
cord-006860-a3b8hyyr	3598	1	To	to	TO
cord-006860-a3b8hyyr	3598	2	exclude	exclude	VB
cord-006860-a3b8hyyr	3598	3	the	the	DT
cord-006860-a3b8hyyr	3598	4	possible	possible	JJ
cord-006860-a3b8hyyr	3598	5	influence	influence	NN
cord-006860-a3b8hyyr	3598	6	of	of	IN
cord-006860-a3b8hyyr	3598	7	rscu	rscu	NNP
cord-006860-a3b8hyyr	3598	8	-	-	HYPH
cord-006860-a3b8hyyr	3598	9	PA	PA	NNP
cord-006860-a3b8hyyr	3598	10	/	/	SYM
cord-006860-a3b8hyyr	3598	11	plasma	plasma	NN
cord-006860-a3b8hyyr	3598	12	interfere	interfere	VBP
cord-006860-a3b8hyyr	3598	13	on	on	IN
cord-006860-a3b8hyyr	3598	14	this	this	DT
cord-006860-a3b8hyyr	3598	15	process	process	NN
cord-006860-a3b8hyyr	3599	1	the	the	DT
cord-006860-a3b8hyyr	3599	2	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3599	3	of	of	IN
cord-006860-a3b8hyyr	3599	4	washed	wash	VBN
cord-006860-a3b8hyyr	3599	5	PLs	PLs	NNPS
cord-006860-a3b8hyyr	3599	6	was	be	VBD
cord-006860-a3b8hyyr	3599	7	under	under	IN
cord-006860-a3b8hyyr	3599	8	the	the	DT
cord-006860-a3b8hyyr	3599	9	investigation	investigation	NN
cord-006860-a3b8hyyr	3599	10	.	.	.
cord-006860-a3b8hyyr	3600	1	PLs	pl	NNS
cord-006860-a3b8hyyr	3600	2	were	be	VBD
cord-006860-a3b8hyyr	3600	3	washed	wash	VBN
cord-006860-a3b8hyyr	3600	4	according	accord	VBG
cord-006860-a3b8hyyr	3600	5	to	to	IN
cord-006860-a3b8hyyr	3600	6	modified	modify	VBN
cord-006860-a3b8hyyr	3600	7	Mustard	Mustard	NNP
cord-006860-a3b8hyyr	3600	8	's	's	POS
cord-006860-a3b8hyyr	3600	9	method	method	NN
cord-006860-a3b8hyyr	3600	10	,	,	,
cord-006860-a3b8hyyr	3600	11	suspended	suspend	VBN
cord-006860-a3b8hyyr	3600	12	in	in	IN
cord-006860-a3b8hyyr	3600	13	buffer	buffer	NN
cord-006860-a3b8hyyr	3600	14	and	and	CC
cord-006860-a3b8hyyr	3600	15	adjusted	adjust	VBN
cord-006860-a3b8hyyr	3600	16	to	to	IN
cord-006860-a3b8hyyr	3600	17	250,109/1	250,109/1	CD
cord-006860-a3b8hyyr	3600	18	.	.	.
cord-006860-a3b8hyyr	3601	1	The	the	DT
cord-006860-a3b8hyyr	3601	2	resuspended	resuspended	JJ
cord-006860-a3b8hyyr	3601	3	PLs	pl	NNS
cord-006860-a3b8hyyr	3601	4	were	be	VBD
cord-006860-a3b8hyyr	3601	5	exposed	expose	VBN
cord-006860-a3b8hyyr	3601	6	to	to	IN
cord-006860-a3b8hyyr	3601	7	5	5	CD
cord-006860-a3b8hyyr	3601	8	-	-	SYM
cord-006860-a3b8hyyr	3601	9	100	100	CD
cord-006860-a3b8hyyr	3601	10	nM	nm	NN
cord-006860-a3b8hyyr	3601	11	of	of	IN
cord-006860-a3b8hyyr	3601	12	rscu	rscu	NNP
cord-006860-a3b8hyyr	3601	13	-	-	HYPH
cord-006860-a3b8hyyr	3601	14	PA	PA	NNP
cord-006860-a3b8hyyr	3601	15	for	for	IN
cord-006860-a3b8hyyr	3601	16	30	30	CD
cord-006860-a3b8hyyr	3601	17	min	min	NN
cord-006860-a3b8hyyr	3601	18	at	at	IN
cord-006860-a3b8hyyr	3601	19	370	370	CD
cord-006860-a3b8hyyr	3601	20	(	(	-LRB-
cord-006860-a3b8hyyr	3601	21	;	;	:
cord-006860-a3b8hyyr	3601	22	.	.	.
cord-006860-a3b8hyyr	3602	1	At	at	IN
cord-006860-a3b8hyyr	3602	2	time	time	NN
cord-006860-a3b8hyyr	3602	3	points	point	VBZ
cord-006860-a3b8hyyr	3602	4	3	3	CD
cord-006860-a3b8hyyr	3602	5	,	,	,
cord-006860-a3b8hyyr	3602	6	5	5	CD
cord-006860-a3b8hyyr	3602	7	,	,	,
cord-006860-a3b8hyyr	3602	8	15	15	CD
cord-006860-a3b8hyyr	3602	9	and	and	CC
cord-006860-a3b8hyyr	3602	10	30	30	CD
cord-006860-a3b8hyyr	3602	11	min	min	NN
cord-006860-a3b8hyyr	3603	1	the	the	DT
cord-006860-a3b8hyyr	3603	2	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3603	3	with	with	IN
cord-006860-a3b8hyyr	3603	4	0.6	0.6	CD
cord-006860-a3b8hyyr	3603	5	IU	IU	NNP
cord-006860-a3b8hyyr	3603	6	/	/	,
cord-006860-a3b8hyyr	3603	7	ml	ml	NNS
cord-006860-a3b8hyyr	3603	8	of	of	IN
cord-006860-a3b8hyyr	3603	9	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3603	10	was	be	VBD
cord-006860-a3b8hyyr	3603	11	measured	measure	VBN
cord-006860-a3b8hyyr	3603	12	.	.	.
cord-006860-a3b8hyyr	3604	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	3604	2	was	be	VBD
cord-006860-a3b8hyyr	3604	3	found	find	VBN
cord-006860-a3b8hyyr	3604	4	that	that	IN
cord-006860-a3b8hyyr	3604	5	the	the	DT
cord-006860-a3b8hyyr	3604	6	exposure	exposure	NN
cord-006860-a3b8hyyr	3604	7	of	of	IN
cord-006860-a3b8hyyr	3604	8	PLs	pl	NNS
cord-006860-a3b8hyyr	3604	9	to	to	IN
cord-006860-a3b8hyyr	3604	10	rscu	rscu	NNP
cord-006860-a3b8hyyr	3604	11	-	-	HYPH
cord-006860-a3b8hyyr	3604	12	PA	PA	NNP
cord-006860-a3b8hyyr	3604	13	(	(	-LRB-
cord-006860-a3b8hyyr	3604	14	20	20	CD
cord-006860-a3b8hyyr	3604	15	-	-	SYM
cord-006860-a3b8hyyr	3604	16	100	100	CD
cord-006860-a3b8hyyr	3604	17	nM	nm	NN
cord-006860-a3b8hyyr	3604	18	)	)	-RRB-
cord-006860-a3b8hyyr	3604	19	for	for	IN
cord-006860-a3b8hyyr	3604	20	3	3	CD
cord-006860-a3b8hyyr	3604	21	mAn	man	NN
cord-006860-a3b8hyyr	3604	22	resulted	result	VBD
cord-006860-a3b8hyyr	3604	23	in	in	IN
cord-006860-a3b8hyyr	3604	24	marked	marked	JJ
cord-006860-a3b8hyyr	3604	25	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3604	26	of	of	IN
cord-006860-a3b8hyyr	3604	27	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3604	28	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3604	29	.	.	.
cord-006860-a3b8hyyr	3605	1	Since	since	IN
cord-006860-a3b8hyyr	3605	2	after	after	IN
cord-006860-a3b8hyyr	3605	3	15	15	CD
cord-006860-a3b8hyyr	3605	4	-	-	SYM
cord-006860-a3b8hyyr	3605	5	30	30	CD
cord-006860-a3b8hyyr	3605	6	mAn	man	NN
cord-006860-a3b8hyyr	3605	7	of	of	IN
cord-006860-a3b8hyyr	3605	8	incubation	incubation	NN
cord-006860-a3b8hyyr	3605	9	with	with	IN
cord-006860-a3b8hyyr	3605	10	20	20	CD
cord-006860-a3b8hyyr	3605	11	-	-	SYM
cord-006860-a3b8hyyr	3605	12	50	50	CD
cord-006860-a3b8hyyr	3605	13	nM	nm	NN
cord-006860-a3b8hyyr	3605	14	of	of	IN
cord-006860-a3b8hyyr	3605	15	rscu	rscu	NNP
cord-006860-a3b8hyyr	3605	16	-	-	HYPH
cord-006860-a3b8hyyr	3605	17	PA	PA	NNP
cord-006860-a3b8hyyr	3605	18	the	the	DT
cord-006860-a3b8hyyr	3605	19	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	3605	20	effect	effect	NN
cord-006860-a3b8hyyr	3605	21	on	on	IN
cord-006860-a3b8hyyr	3605	22	PL	pl	NN
cord-006860-a3b8hyyr	3605	23	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3605	24	became	become	VBD
cord-006860-a3b8hyyr	3605	25	less	less	RBR
cord-006860-a3b8hyyr	3605	26	pronounce	pronounce	VB
cord-006860-a3b8hyyr	3605	27	or	or	CC
cord-006860-a3b8hyyr	3605	28	even	even	RB
cord-006860-a3b8hyyr	3605	29	disappeared	disappear	VBD
cord-006860-a3b8hyyr	3605	30	.	.	.
cord-006860-a3b8hyyr	3606	1	When	when	WRB
cord-006860-a3b8hyyr	3606	2	5	5	CD
cord-006860-a3b8hyyr	3606	3	nM	nm	CD
cord-006860-a3b8hyyr	3606	4	of	of	IN
cord-006860-a3b8hyyr	3606	5	rseu	rseu	NNP
cord-006860-a3b8hyyr	3606	6	-	-	:
cord-006860-a3b8hyyr	3606	7	PA	PA	NNP
cord-006860-a3b8hyyr	3606	8	was	be	VBD
cord-006860-a3b8hyyr	3606	9	used	use	VBN
cord-006860-a3b8hyyr	3606	10	the	the	DT
cord-006860-a3b8hyyr	3606	11	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3606	12	of	of	IN
cord-006860-a3b8hyyr	3606	13	PL	pl	NN
cord-006860-a3b8hyyr	3606	14	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3606	15	became	become	VBD
cord-006860-a3b8hyyr	3606	16	significant	significant	JJ
cord-006860-a3b8hyyr	3606	17	only	only	RB
cord-006860-a3b8hyyr	3606	18	by	by	IN
cord-006860-a3b8hyyr	3606	19	15	15	CD
cord-006860-a3b8hyyr	3606	20	rain	rain	NN
cord-006860-a3b8hyyr	3606	21	of	of	IN
cord-006860-a3b8hyyr	3606	22	exposure	exposure	NN
cord-006860-a3b8hyyr	3606	23	period	period	NN
cord-006860-a3b8hyyr	3606	24	and	and	CC
cord-006860-a3b8hyyr	3606	25	did	do	VBD
cord-006860-a3b8hyyr	3606	26	n't	not	RB
cord-006860-a3b8hyyr	3606	27	change	change	VB
cord-006860-a3b8hyyr	3606	28	for	for	IN
cord-006860-a3b8hyyr	3606	29	30	30	CD
cord-006860-a3b8hyyr	3606	30	man	man	NN
cord-006860-a3b8hyyr	3606	31	of	of	IN
cord-006860-a3b8hyyr	3606	32	investigation	investigation	NN
cord-006860-a3b8hyyr	3606	33	.	.	.
cord-006860-a3b8hyyr	3607	1	The	the	DT
cord-006860-a3b8hyyr	3607	2	observed	observed	JJ
cord-006860-a3b8hyyr	3607	3	results	result	NNS
cord-006860-a3b8hyyr	3607	4	may	may	MD
cord-006860-a3b8hyyr	3607	5	be	be	VB
cord-006860-a3b8hyyr	3607	6	cormeeted	cormeete	VBN
cord-006860-a3b8hyyr	3607	7	with	with	IN
cord-006860-a3b8hyyr	3607	8	uptake	uptake	NN
cord-006860-a3b8hyyr	3607	9	of	of	IN
cord-006860-a3b8hyyr	3607	10	rscu	rscu	NNP
cord-006860-a3b8hyyr	3607	11	-	-	HYPH
cord-006860-a3b8hyyr	3607	12	PA	PA	NNP
cord-006860-a3b8hyyr	3607	13	by	by	IN
cord-006860-a3b8hyyr	3607	14	PLs	pl	NNS
cord-006860-a3b8hyyr	3607	15	from	from	IN
cord-006860-a3b8hyyr	3607	16	surrounding	surround	VBG
cord-006860-a3b8hyyr	3607	17	buffer	buffer	NN
cord-006860-a3b8hyyr	3607	18	as	as	RB
cord-006860-a3b8hyyr	3607	19	well	well	RB
cord-006860-a3b8hyyr	3607	20	as	as	IN
cord-006860-a3b8hyyr	3607	21	with	with	IN
cord-006860-a3b8hyyr	3607	22	individual	individual	JJ
cord-006860-a3b8hyyr	3607	23	variations	variation	NNS
cord-006860-a3b8hyyr	3607	24	of	of	IN
cord-006860-a3b8hyyr	3607	25	PL	pl	NN
cord-006860-a3b8hyyr	3607	26	response	response	NN
cord-006860-a3b8hyyr	3607	27	to	to	IN
cord-006860-a3b8hyyr	3607	28	the	the	DT
cord-006860-a3b8hyyr	3607	29	same	same	JJ
cord-006860-a3b8hyyr	3607	30	concentration	concentration	NN
cord-006860-a3b8hyyr	3607	31	of	of	IN
cord-006860-a3b8hyyr	3607	32	rscu	rscu	NNP
cord-006860-a3b8hyyr	3607	33	-	-	HYPH
cord-006860-a3b8hyyr	3607	34	PA	PA	NNP
cord-006860-a3b8hyyr	3607	35	.	.	.
cord-006860-a3b8hyyr	3608	1	Loss	loss	NN
cord-006860-a3b8hyyr	3608	2	of	of	IN
cord-006860-a3b8hyyr	3608	3	glycosylation	glycosylation	NN
cord-006860-a3b8hyyr	3608	4	may	may	MD
cord-006860-a3b8hyyr	3608	5	result	result	VB
cord-006860-a3b8hyyr	3608	6	in	in	IN
cord-006860-a3b8hyyr	3608	7	a	a	DT
cord-006860-a3b8hyyr	3608	8	reduced	reduced	JJ
cord-006860-a3b8hyyr	3608	9	platelet	platelet	NN
cord-006860-a3b8hyyr	3608	10	(	(	-LRB-
cord-006860-a3b8hyyr	3608	11	P	p	NN
cord-006860-a3b8hyyr	3608	12	)	)	-RRB-
cord-006860-a3b8hyyr	3608	13	survival	survival	NN
cord-006860-a3b8hyyr	3608	14	and	and	CC
cord-006860-a3b8hyyr	3608	15	perhaps	perhaps	RB
cord-006860-a3b8hyyr	3608	16	altered	alter	VBN
cord-006860-a3b8hyyr	3608	17	function	function	NN
cord-006860-a3b8hyyr	3608	18	.	.	.
cord-006860-a3b8hyyr	3609	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3609	2	analyzed	analyze	VBD
cord-006860-a3b8hyyr	3609	3	the	the	DT
cord-006860-a3b8hyyr	3609	4	structural	structural	JJ
cord-006860-a3b8hyyr	3609	5	and	and	CC
cord-006860-a3b8hyyr	3609	6	functional	functional	JJ
cord-006860-a3b8hyyr	3609	7	effect	effect	NN
cord-006860-a3b8hyyr	3609	8	of	of	IN
cord-006860-a3b8hyyr	3609	9	specific	specific	JJ
cord-006860-a3b8hyyr	3609	10	deglycosylation	deglycosylation	NN
cord-006860-a3b8hyyr	3609	11	(	(	-LRB-
cord-006860-a3b8hyyr	3609	12	combinations	combination	NNS
cord-006860-a3b8hyyr	3609	13	of	of	IN
cord-006860-a3b8hyyr	3609	14	N	N	NNP
cord-006860-a3b8hyyr	3609	15	/	/	SYM
cord-006860-a3b8hyyr	3609	16	O	o	NN
cord-006860-a3b8hyyr	3609	17	-	-	HYPH
cord-006860-a3b8hyyr	3609	18	glycosidase	glycosidase	NN
cord-006860-a3b8hyyr	3609	19	and	and	CC
cord-006860-a3b8hyyr	3609	20	neuraminidase	neuraminidase	NN
cord-006860-a3b8hyyr	3609	21	treatment	treatment	NN
cord-006860-a3b8hyyr	3609	22	)	)	-RRB-
cord-006860-a3b8hyyr	3609	23	of	of	IN
cord-006860-a3b8hyyr	3609	24	P	p	NN
cord-006860-a3b8hyyr	3609	25	and	and	CC
cord-006860-a3b8hyyr	3609	26	isolated	isolate	VBN
cord-006860-a3b8hyyr	3609	27	P	p	NN
cord-006860-a3b8hyyr	3609	28	GPIb	GPIb	NNS
cord-006860-a3b8hyyr	3609	29	.	.	.
cord-006860-a3b8hyyr	3610	1	Washed	wash	VBN
cord-006860-a3b8hyyr	3610	2	and	and	CC
cord-006860-a3b8hyyr	3610	3	formaldehyde	formaldehyde	NN
cord-006860-a3b8hyyr	3610	4	-	-	HYPH
cord-006860-a3b8hyyr	3610	5	fixed	fix	VBN
cord-006860-a3b8hyyr	3610	6	P	p	NN
cord-006860-a3b8hyyr	3610	7	were	be	VBD
cord-006860-a3b8hyyr	3610	8	digested	digest	VBN
cord-006860-a3b8hyyr	3610	9	as	as	IN
cord-006860-a3b8hyyr	3610	10	follows	follow	VBZ
cord-006860-a3b8hyyr	3610	11	:	:	:
cord-006860-a3b8hyyr	3611	1	1	1	LS
cord-006860-a3b8hyyr	3611	2	)	)	-RRB-
cord-006860-a3b8hyyr	3611	3	With	with	IN
cord-006860-a3b8hyyr	3611	4	neuraminidase	neuraminidase	NN
cord-006860-a3b8hyyr	3611	5	(	(	-LRB-
cord-006860-a3b8hyyr	3611	6	0.125U	0.125u	CD
cord-006860-a3b8hyyr	3612	1	/ml	/ml	NFP
cord-006860-a3b8hyyr	3612	2	)	)	-RRB-
cord-006860-a3b8hyyr	3612	3	+	+	.
cord-006860-a3b8hyyr	3613	1	O	o	UH
cord-006860-a3b8hyyr	3613	2	-	-	HYPH
cord-006860-a3b8hyyr	3613	3	glycosidase	glycosidase	NN
cord-006860-a3b8hyyr	3613	4	(	(	-LRB-
cord-006860-a3b8hyyr	3613	5	3.1mU	3.1mu	CD
cord-006860-a3b8hyyr	3613	6	/	/	SYM
cord-006860-a3b8hyyr	3613	7	ml	ml	NN
cord-006860-a3b8hyyr	3613	8	)	)	-RRB-
cord-006860-a3b8hyyr	3614	1	+	+	CC
cord-006860-a3b8hyyr	3615	1	N	N	NNP
cord-006860-a3b8hyyr	3615	2	-	-	HYPH
cord-006860-a3b8hyyr	3615	3	glycosidase	glycosidase	NN
cord-006860-a3b8hyyr	3615	4	(	(	-LRB-
cord-006860-a3b8hyyr	3615	5	1.25U	1.25u	CD
cord-006860-a3b8hyyr	3615	6	/	/	SYM
cord-006860-a3b8hyyr	3615	7	ml	ml	NN
cord-006860-a3b8hyyr	3615	8	)	)	-RRB-
cord-006860-a3b8hyyr	3615	9	,	,	,
cord-006860-a3b8hyyr	3615	10	2	2	CD
cord-006860-a3b8hyyr	3615	11	)	)	-RRB-
cord-006860-a3b8hyyr	3615	12	with	with	IN
cord-006860-a3b8hyyr	3615	13	neuraminidase	neuraminidase	NN
cord-006860-a3b8hyyr	3615	14	alone	alone	RB
cord-006860-a3b8hyyr	3616	1	(	(	-LRB-
cord-006860-a3b8hyyr	3616	2	0.2U	0.2U	NNP
cord-006860-a3b8hyyr	3616	3	/	/	SYM
cord-006860-a3b8hyyr	3616	4	ml	ml	NNP
cord-006860-a3b8hyyr	3616	5	)	)	-RRB-
cord-006860-a3b8hyyr	3616	6	,	,	.
cord-006860-a3b8hyyr	3617	1	3	3	LS
cord-006860-a3b8hyyr	3617	2	)	)	-RRB-
cord-006860-a3b8hyyr	3617	3	with	with	IN
cord-006860-a3b8hyyr	3617	4	N	N	NNP
cord-006860-a3b8hyyr	3617	5	-	-	HYPH
cord-006860-a3b8hyyr	3617	6	glycosidase	glycosidase	NNP
cord-006860-a3b8hyyr	3617	7	(	(	-LRB-
cord-006860-a3b8hyyr	3617	8	2U	2U	NNP
cord-006860-a3b8hyyr	3617	9	/	/	SYM
cord-006860-a3b8hyyr	3617	10	rnl	rnl	NNP
cord-006860-a3b8hyyr	3617	11	)	)	-RRB-
cord-006860-a3b8hyyr	3617	12	and	and	CC
cord-006860-a3b8hyyr	3617	13	4	4	CD
cord-006860-a3b8hyyr	3617	14	)	)	-RRB-
cord-006860-a3b8hyyr	3618	1	with	with	IN
cord-006860-a3b8hyyr	3618	2	neuraminldase	neuraminldase	NNP
cord-006860-a3b8hyyr	3618	3	(	(	-LRB-
cord-006860-a3b8hyyr	3618	4	0.2U	0.2U	NNP
cord-006860-a3b8hyyr	3618	5	/	/	SYM
cord-006860-a3b8hyyr	3618	6	ml	ml	NN
cord-006860-a3b8hyyr	3618	7	)	)	-RRB-
cord-006860-a3b8hyyr	3619	1	+	+	CC
cord-006860-a3b8hyyr	3620	1	O	o	UH
cord-006860-a3b8hyyr	3620	2	-	-	HYPH
cord-006860-a3b8hyyr	3620	3	glycosidase	glycosidase	NN
cord-006860-a3b8hyyr	3620	4	(	(	-LRB-
cord-006860-a3b8hyyr	3620	5	5mU	5mu	CD
cord-006860-a3b8hyyr	3620	6	/	/	SYM
cord-006860-a3b8hyyr	3620	7	ml	ml	NN
cord-006860-a3b8hyyr	3620	8	)	)	-RRB-
cord-006860-a3b8hyyr	3620	9	.	.	.
cord-006860-a3b8hyyr	3621	1	All	all	DT
cord-006860-a3b8hyyr	3621	2	reactions	reaction	NNS
cord-006860-a3b8hyyr	3621	3	were	be	VBD
cord-006860-a3b8hyyr	3621	4	performed	perform	VBN
cord-006860-a3b8hyyr	3621	5	in	in	IN
cord-006860-a3b8hyyr	3621	6	the	the	DT
cord-006860-a3b8hyyr	3621	7	presence	presence	NN
cord-006860-a3b8hyyr	3621	8	of	of	IN
cord-006860-a3b8hyyr	3621	9	protease	protease	NN
cord-006860-a3b8hyyr	3621	10	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3621	11	(	(	-LRB-
cord-006860-a3b8hyyr	3621	12	PMSF	PMSF	NNP
cord-006860-a3b8hyyr	3621	13	,	,	,
cord-006860-a3b8hyyr	3621	14	Leupeptin	Leupeptin	NNP
cord-006860-a3b8hyyr	3621	15	,	,	,
cord-006860-a3b8hyyr	3621	16	SBTI	SBTI	NNP
cord-006860-a3b8hyyr	3621	17	)	)	-RRB-
cord-006860-a3b8hyyr	3621	18	,	,	,
cord-006860-a3b8hyyr	3621	19	After	after	IN
cord-006860-a3b8hyyr	3621	20	washing	wash	VBG
cord-006860-a3b8hyyr	3621	21	x2	x2	NN
cord-006860-a3b8hyyr	3621	22	the	the	DT
cord-006860-a3b8hyyr	3621	23	P	p	NN
cord-006860-a3b8hyyr	3621	24	and	and	CC
cord-006860-a3b8hyyr	3621	25	identically	identically	RB
cord-006860-a3b8hyyr	3621	26	treated	treat	VBN
cord-006860-a3b8hyyr	3621	27	controls	control	NNS
cord-006860-a3b8hyyr	3621	28	were	be	VBD
cord-006860-a3b8hyyr	3621	29	analyzed	analyze	VBN
cord-006860-a3b8hyyr	3621	30	by	by	IN
cord-006860-a3b8hyyr	3621	31	flowcytometry	flowcytometry	NN
cord-006860-a3b8hyyr	3621	32	with	with	IN
cord-006860-a3b8hyyr	3621	33	the	the	DT
cord-006860-a3b8hyyr	3621	34	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3622	1	6DI	6di	CD
cord-006860-a3b8hyyr	3623	1	(	(	-LRB-
cord-006860-a3b8hyyr	3623	2	Mab	Mab	NNP
cord-006860-a3b8hyyr	3623	3	:	:	:
cord-006860-a3b8hyyr	3623	4	a	a	LS
cord-006860-a3b8hyyr	3623	5	-	-	HYPH
cord-006860-a3b8hyyr	3623	6	GPIb	GPIb	NNS
cord-006860-a3b8hyyr	3623	7	)	)	-RRB-
cord-006860-a3b8hyyr	3624	1	,	,	,
cord-006860-a3b8hyyr	3624	2	7I	7i	CD
cord-006860-a3b8hyyr	3624	3	-	-	HYPH
cord-006860-a3b8hyyr	3624	4	L2	L2	NNP
cord-006860-a3b8hyyr	3624	5	0Vlab	0Vlab	NNP
cord-006860-a3b8hyyr	3624	6	:	:	:
cord-006860-a3b8hyyr	3624	7	a	a	LS
cord-006860-a3b8hyyr	3624	8	-	-	:
cord-006860-a3b8hyyr	3624	9	GPIIIa	GPIIIa	NNS
cord-006860-a3b8hyyr	3624	10	)	)	-RRB-
cord-006860-a3b8hyyr	3624	11	,	,	,
cord-006860-a3b8hyyr	3624	12	and	and	CC
cord-006860-a3b8hyyr	3624	13	the	the	DT
cord-006860-a3b8hyyr	3624	14	lectins	lectin	NNS
cord-006860-a3b8hyyr	3624	15	wheat	wheat	NN
cord-006860-a3b8hyyr	3624	16	germ	germ	NN
cord-006860-a3b8hyyr	3624	17	agglutinatinln	agglutinatinln	NN
cord-006860-a3b8hyyr	3624	18	(	(	-LRB-
cord-006860-a3b8hyyr	3624	19	WGA	WGA	NNP
cord-006860-a3b8hyyr	3624	20	,	,	,
cord-006860-a3b8hyyr	3624	21	for	for	IN
cord-006860-a3b8hyyr	3624	22	NeuNac	NeuNac	NNP
cord-006860-a3b8hyyr	3624	23	)	)	-RRB-
cord-006860-a3b8hyyr	3624	24	and	and	CC
cord-006860-a3b8hyyr	3624	25	peanut	peanut	NNP
cord-006860-a3b8hyyr	3624	26	agglutinin	agglutinin	NNS
cord-006860-a3b8hyyr	3624	27	(	(	-LRB-
cord-006860-a3b8hyyr	3624	28	PNA	PNA	NNP
cord-006860-a3b8hyyr	3624	29	,	,	,
cord-006860-a3b8hyyr	3624	30	for	for	IN
cord-006860-a3b8hyyr	3624	31	[	[	-LRB-
cord-006860-a3b8hyyr	3624	32	3DGal(1	3DGal(1	NNP
cord-006860-a3b8hyyr	3624	33	-	-	HYPH
cord-006860-a3b8hyyr	3624	34	3)-GalNac	3)-GalNac	NNP
cord-006860-a3b8hyyr	3624	35	)	)	-RRB-
cord-006860-a3b8hyyr	3624	36	which	which	WDT
cord-006860-a3b8hyyr	3624	37	confirmed	confirm	VBD
cord-006860-a3b8hyyr	3624	38	effective	effective	JJ
cord-006860-a3b8hyyr	3624	39	and	and	CC
cord-006860-a3b8hyyr	3624	40	specific	specific	JJ
cord-006860-a3b8hyyr	3624	41	deglycosylation	deglycosylation	NN
cord-006860-a3b8hyyr	3624	42	by	by	IN
cord-006860-a3b8hyyr	3624	43	the	the	DT
cord-006860-a3b8hyyr	3624	44	respective	respective	JJ
cord-006860-a3b8hyyr	3624	45	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	3624	46	(	(	-LRB-
cord-006860-a3b8hyyr	3624	47	but	but	CC
cord-006860-a3b8hyyr	3624	48	gave	give	VBD
cord-006860-a3b8hyyr	3624	49	only	only	JJ
cord-006860-a3b8hyyr	3624	50	minor	minor	JJ
cord-006860-a3b8hyyr	3624	51	differences	difference	NNS
cord-006860-a3b8hyyr	3624	52	with	with	IN
cord-006860-a3b8hyyr	3624	53	6DI	6di	CD
cord-006860-a3b8hyyr	3624	54	and	and	CC
cord-006860-a3b8hyyr	3624	55	7H2	7h2	CD
cord-006860-a3b8hyyr	3624	56	)	)	-RRB-
cord-006860-a3b8hyyr	3624	57	.	.	.
cord-006860-a3b8hyyr	3625	1	The	the	DT
cord-006860-a3b8hyyr	3625	2	botrocetin	botrocetin	NNS
cord-006860-a3b8hyyr	3625	3	(	(	-LRB-
cord-006860-a3b8hyyr	3625	4	13	13	CD
cord-006860-a3b8hyyr	3625	5	)	)	-RRB-
cord-006860-a3b8hyyr	3625	6	and	and	CC
cord-006860-a3b8hyyr	3625	7	ristocetin	ristocetin	JJ
cord-006860-a3b8hyyr	3625	8	(	(	-LRB-
cord-006860-a3b8hyyr	3625	9	R)induced	r)induced	JJ
cord-006860-a3b8hyyr	3625	10	agglutinations	agglutination	NNS
cord-006860-a3b8hyyr	3625	11	showed	show	VBD
cord-006860-a3b8hyyr	3625	12	aRer	aRer	NNP
cord-006860-a3b8hyyr	3625	13	treatment	treatment	NN
cord-006860-a3b8hyyr	3625	14	1	1	CD
cord-006860-a3b8hyyr	3625	15	)	)	-RRB-
cord-006860-a3b8hyyr	3625	16	(	(	-LRB-
cord-006860-a3b8hyyr	3625	17	all	all	DT
cord-006860-a3b8hyyr	3625	18	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	3625	19	)	)	-RRB-
cord-006860-a3b8hyyr	3625	20	a	a	DT
cord-006860-a3b8hyyr	3625	21	full	full	JJ
cord-006860-a3b8hyyr	3625	22	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3625	23	of	of	IN
cord-006860-a3b8hyyr	3625	24	R	r	NN
cord-006860-a3b8hyyr	3625	25	-	-	HYPH
cord-006860-a3b8hyyr	3625	26	induced	induce	VBN
cord-006860-a3b8hyyr	3625	27	agglutination	agglutination	NN
cord-006860-a3b8hyyr	3625	28	but	but	CC
cord-006860-a3b8hyyr	3625	29	only	only	RB
cord-006860-a3b8hyyr	3625	30	a	a	DT
cord-006860-a3b8hyyr	3625	31	mildly	mildly	RB
cord-006860-a3b8hyyr	3625	32	reduced	reduce	VBN
cord-006860-a3b8hyyr	3625	33	B	b	NN
cord-006860-a3b8hyyr	3625	34	-	-	HYPH
cord-006860-a3b8hyyr	3625	35	induced	induce	VBN
cord-006860-a3b8hyyr	3625	36	agglutination	agglutination	NN
cord-006860-a3b8hyyr	3625	37	(	(	-LRB-
cord-006860-a3b8hyyr	3625	38	70	70	CD
cord-006860-a3b8hyyr	3625	39	%	%	NN
cord-006860-a3b8hyyr	3625	40	of	of	IN
cord-006860-a3b8hyyr	3625	41	normal	normal	JJ
cord-006860-a3b8hyyr	3625	42	)	)	-RRB-
cord-006860-a3b8hyyr	3625	43	.	.	.
cord-006860-a3b8hyyr	3626	1	Treatment	treatment	NN
cord-006860-a3b8hyyr	3626	2	2	2	CD
cord-006860-a3b8hyyr	3626	3	and	and	CC
cord-006860-a3b8hyyr	3626	4	3	3	CD
cord-006860-a3b8hyyr	3626	5	(	(	-LRB-
cord-006860-a3b8hyyr	3626	6	neuraminidase	neuraminidase	NN
cord-006860-a3b8hyyr	3626	7	alone	alone	RB
cord-006860-a3b8hyyr	3626	8	,	,	,
cord-006860-a3b8hyyr	3626	9	and	and	CC
cord-006860-a3b8hyyr	3626	10	N	n	CD
cord-006860-a3b8hyyr	3626	11	-	-	HYPH
cord-006860-a3b8hyyr	3626	12	glycosidase	glycosidase	NN
cord-006860-a3b8hyyr	3626	13	alone	alone	RB
cord-006860-a3b8hyyr	3626	14	)	)	-RRB-
cord-006860-a3b8hyyr	3626	15	affected	affect	VBD
cord-006860-a3b8hyyr	3626	16	both	both	DT
cord-006860-a3b8hyyr	3626	17	agglutinations	agglutination	NNS
cord-006860-a3b8hyyr	3626	18	only	only	RB
cord-006860-a3b8hyyr	3626	19	mildly	mildly	RB
cord-006860-a3b8hyyr	3626	20	(	(	-LRB-
cord-006860-a3b8hyyr	3626	21	70	70	CD
cord-006860-a3b8hyyr	3626	22	-	-	SYM
cord-006860-a3b8hyyr	3626	23	80	80	CD
cord-006860-a3b8hyyr	3626	24	%	%	NN
cord-006860-a3b8hyyr	3626	25	of	of	IN
cord-006860-a3b8hyyr	3626	26	normal).Treatrnent	normal).treatrnent	NN
cord-006860-a3b8hyyr	3626	27	4	4	CD
cord-006860-a3b8hyyr	3626	28	)	)	-RRB-
cord-006860-a3b8hyyr	3626	29	(	(	-LRB-
cord-006860-a3b8hyyr	3627	1	O	o	NN
cord-006860-a3b8hyyr	3627	2	-	-	HYPH
cord-006860-a3b8hyyr	3627	3	deglycosylation	deglycosylation	NN
cord-006860-a3b8hyyr	3627	4	)	)	-RRB-
cord-006860-a3b8hyyr	3627	5	however	however	RB
cord-006860-a3b8hyyr	3627	6	showed	show	VBD
cord-006860-a3b8hyyr	3627	7	a	a	DT
cord-006860-a3b8hyyr	3627	8	major	major	JJ
cord-006860-a3b8hyyr	3627	9	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3627	10	of	of	IN
cord-006860-a3b8hyyr	3627	11	R	r	NN
cord-006860-a3b8hyyr	3627	12	-	-	HYPH
cord-006860-a3b8hyyr	3627	13	agglutination	agglutination	NN
cord-006860-a3b8hyyr	3627	14	down	down	RB
cord-006860-a3b8hyyr	3627	15	to	to	IN
cord-006860-a3b8hyyr	3627	16	30	30	CD
cord-006860-a3b8hyyr	3627	17	%	%	NN
cord-006860-a3b8hyyr	3627	18	,	,	,
cord-006860-a3b8hyyr	3627	19	while	while	IN
cord-006860-a3b8hyyr	3627	20	B	b	NN
cord-006860-a3b8hyyr	3627	21	-	-	HYPH
cord-006860-a3b8hyyr	3627	22	agglutination	agglutination	NN
cord-006860-a3b8hyyr	3627	23	interestingly	interestingly	RB
cord-006860-a3b8hyyr	3627	24	was	be	VBD
cord-006860-a3b8hyyr	3627	25	almost	almost	RB
cord-006860-a3b8hyyr	3627	26	fully	fully	RB
cord-006860-a3b8hyyr	3627	27	retained	retain	VBN
cord-006860-a3b8hyyr	3627	28	.	.	.
cord-006860-a3b8hyyr	3628	1	The	the	DT
cord-006860-a3b8hyyr	3628	2	results	result	NNS
cord-006860-a3b8hyyr	3628	3	of	of	IN
cord-006860-a3b8hyyr	3628	4	the	the	DT
cord-006860-a3b8hyyr	3628	5	rotary	rotary	JJ
cord-006860-a3b8hyyr	3628	6	shadowing	shadow	VBG
cord-006860-a3b8hyyr	3628	7	electron	electron	NN
cord-006860-a3b8hyyr	3628	8	microscopy	microscopy	NN
cord-006860-a3b8hyyr	3628	9	of	of	IN
cord-006860-a3b8hyyr	3628	10	purified	purify	VBN
cord-006860-a3b8hyyr	3628	11	GPIb	GPIb	NNS
cord-006860-a3b8hyyr	3628	12	suggested	suggest	VBD
cord-006860-a3b8hyyr	3628	13	a	a	DT
cord-006860-a3b8hyyr	3628	14	collapse	collapse	NN
cord-006860-a3b8hyyr	3628	15	of	of	IN
cord-006860-a3b8hyyr	3628	16	the	the	DT
cord-006860-a3b8hyyr	3628	17	normally	normally	RB
cord-006860-a3b8hyyr	3628	18	stretched	stretch	VBN
cord-006860-a3b8hyyr	3628	19	,	,	,
cord-006860-a3b8hyyr	3628	20	glycosylated	glycosylate	VBN
cord-006860-a3b8hyyr	3628	21	,	,	,
cord-006860-a3b8hyyr	3628	22	GPlb	GPlb	NNP
cord-006860-a3b8hyyr	3628	23	,	,	,
cord-006860-a3b8hyyr	3628	24	not	not	RB
cord-006860-a3b8hyyr	3628	25	only	only	RB
cord-006860-a3b8hyyr	3628	26	after	after	IN
cord-006860-a3b8hyyr	3628	27	the	the	DT
cord-006860-a3b8hyyr	3628	28	treatment	treatment	NN
cord-006860-a3b8hyyr	3628	29	with	with	IN
cord-006860-a3b8hyyr	3628	30	all	all	DT
cord-006860-a3b8hyyr	3628	31	three	three	CD
cord-006860-a3b8hyyr	3628	32	glycosidases	glycosidase	NNS
cord-006860-a3b8hyyr	3628	33	,	,	,
cord-006860-a3b8hyyr	3628	34	but	but	CC
cord-006860-a3b8hyyr	3628	35	also	also	RB
cord-006860-a3b8hyyr	3628	36	.after	.after	NFP
cord-006860-a3b8hyyr	3628	37	O	o	NN
cord-006860-a3b8hyyr	3628	38	-	-	HYPH
cord-006860-a3b8hyyr	3628	39	deglycosylation	deglycosylation	NN
cord-006860-a3b8hyyr	3628	40	alone	alone	RB
cord-006860-a3b8hyyr	3628	41	.	.	.
cord-006860-a3b8hyyr	3629	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3629	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	3629	3	that	that	IN
cord-006860-a3b8hyyr	3629	4	Oglycosylation	Oglycosylation	NNP
cord-006860-a3b8hyyr	3629	5	is	be	VBZ
cord-006860-a3b8hyyr	3629	6	most	most	RBS
cord-006860-a3b8hyyr	3629	7	important	important	JJ
cord-006860-a3b8hyyr	3629	8	for	for	IN
cord-006860-a3b8hyyr	3629	9	ristocetin	ristocetin	NN
cord-006860-a3b8hyyr	3629	10	-	-	HYPH
cord-006860-a3b8hyyr	3629	11	induced	induce	VBN
cord-006860-a3b8hyyr	3629	12	platelet	platelet	NN
cord-006860-a3b8hyyr	3629	13	-	-	HYPH
cord-006860-a3b8hyyr	3629	14	von	von	NNP
cord-006860-a3b8hyyr	3629	15	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	3629	16	factor	factor	NN
cord-006860-a3b8hyyr	3629	17	-	-	HYPH
cord-006860-a3b8hyyr	3629	18	interaction	interaction	NN
cord-006860-a3b8hyyr	3629	19	and	and	CC
cord-006860-a3b8hyyr	3629	20	responsible	responsible	JJ
cord-006860-a3b8hyyr	3629	21	for	for	IN
cord-006860-a3b8hyyr	3629	22	the	the	DT
cord-006860-a3b8hyyr	3629	23	typical	typical	JJ
cord-006860-a3b8hyyr	3629	24	stretched	stretched	JJ
cord-006860-a3b8hyyr	3629	25	shape	shape	NN
cord-006860-a3b8hyyr	3629	26	.	.	.
cord-006860-a3b8hyyr	3630	1	The	the	DT
cord-006860-a3b8hyyr	3630	2	phenomenon	phenomenon	NN
cord-006860-a3b8hyyr	3630	3	of	of	IN
cord-006860-a3b8hyyr	3630	4	in	in	FW
cord-006860-a3b8hyyr	3630	5	vitro	vitro	FW
cord-006860-a3b8hyyr	3630	6	platelet	platelet	NN
cord-006860-a3b8hyyr	3630	7	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3630	8	and	and	CC
cord-006860-a3b8hyyr	3630	9	consequent	consequent	JJ
cord-006860-a3b8hyyr	3630	10	pseudothrombocytopenia	pseudothrombocytopenia	NN
cord-006860-a3b8hyyr	3630	11	(	(	-LRB-
cord-006860-a3b8hyyr	3630	12	PTCP	PTCP	NNP
cord-006860-a3b8hyyr	3630	13	)	)	-RRB-
cord-006860-a3b8hyyr	3630	14	in	in	IN
cord-006860-a3b8hyyr	3630	15	the	the	DT
cord-006860-a3b8hyyr	3630	16	presence	presence	NN
cord-006860-a3b8hyyr	3630	17	of	of	IN
cord-006860-a3b8hyyr	3630	18	calciumchelatization	calciumchelatization	NN
cord-006860-a3b8hyyr	3630	19	by	by	IN
cord-006860-a3b8hyyr	3630	20	Na	Na	NNP
cord-006860-a3b8hyyr	3630	21	-	-	HYPH
cord-006860-a3b8hyyr	3630	22	EDTA	EDTA	NNP
cord-006860-a3b8hyyr	3630	23	and	and	CC
cord-006860-a3b8hyyr	3630	24	sodium	sodium	NN
cord-006860-a3b8hyyr	3630	25	-	-	HYPH
cord-006860-a3b8hyyr	3630	26	citrate	citrate	NN
cord-006860-a3b8hyyr	3630	27	was	be	VBD
cord-006860-a3b8hyyr	3630	28	studied	study	VBN
cord-006860-a3b8hyyr	3630	29	in	in	IN
cord-006860-a3b8hyyr	3630	30	blood	blood	NN
cord-006860-a3b8hyyr	3630	31	samples	sample	NNS
cord-006860-a3b8hyyr	3630	32	of	of	IN
cord-006860-a3b8hyyr	3630	33	a	a	DT
cord-006860-a3b8hyyr	3630	34	patient	patient	NN
cord-006860-a3b8hyyr	3630	35	.	.	.
cord-006860-a3b8hyyr	3631	1	Initial	initial	JJ
cord-006860-a3b8hyyr	3631	2	platelet	platelet	NN
cord-006860-a3b8hyyr	3631	3	counts	count	VBZ
cord-006860-a3b8hyyr	3631	4	electronically	electronically	RB
cord-006860-a3b8hyyr	3631	5	measured	measure	VBN
cord-006860-a3b8hyyr	3631	6	were	be	VBD
cord-006860-a3b8hyyr	3631	7	20000	20000	CD
cord-006860-a3b8hyyr	3631	8	/	/	SYM
cord-006860-a3b8hyyr	3631	9	ul	ul	NN
cord-006860-a3b8hyyr	3631	10	blood	blood	NN
cord-006860-a3b8hyyr	3631	11	anticoagulated	anticoagulate	VBN
cord-006860-a3b8hyyr	3631	12	with	with	IN
cord-006860-a3b8hyyr	3631	13	Na	Na	NNP
cord-006860-a3b8hyyr	3631	14	-	-	HYPH
cord-006860-a3b8hyyr	3631	15	EDTA	EDTA	NNP
cord-006860-a3b8hyyr	3631	16	and	and	CC
cord-006860-a3b8hyyr	3631	17	sodium	sodium	NN
cord-006860-a3b8hyyr	3631	18	-	-	HYPH
cord-006860-a3b8hyyr	3631	19	citrate	citrate	NN
cord-006860-a3b8hyyr	3631	20	.	.	.
cord-006860-a3b8hyyr	3632	1	Normal	normal	JJ
cord-006860-a3b8hyyr	3632	2	platelet	platelet	NN
cord-006860-a3b8hyyr	3632	3	counts	count	NNS
cord-006860-a3b8hyyr	3632	4	were	be	VBD
cord-006860-a3b8hyyr	3632	5	found	find	VBN
cord-006860-a3b8hyyr	3632	6	in	in	IN
cord-006860-a3b8hyyr	3632	7	heparin	heparin	NN
cord-006860-a3b8hyyr	3632	8	-	-	HYPH
cord-006860-a3b8hyyr	3632	9	anticoagulated	anticoagulate	VBN
cord-006860-a3b8hyyr	3632	10	blood	blood	NN
cord-006860-a3b8hyyr	3632	11	and	and	CC
cord-006860-a3b8hyyr	3632	12	in	in	IN
cord-006860-a3b8hyyr	3632	13	capillary	capillary	JJ
cord-006860-a3b8hyyr	3632	14	blood	blood	NN
cord-006860-a3b8hyyr	3632	15	.	.	.
cord-006860-a3b8hyyr	3633	1	Immunoglobulines	immunoglobuline	NNS
cord-006860-a3b8hyyr	3633	2	of	of	IN
cord-006860-a3b8hyyr	3633	3	the	the	DT
cord-006860-a3b8hyyr	3633	4	IgG	IgG	NNP
cord-006860-a3b8hyyr	3633	5	and	and	CC
cord-006860-a3b8hyyr	3633	6	IgM	IgM	NNP
cord-006860-a3b8hyyr	3633	7	subclass	subclass	NNP
cord-006860-a3b8hyyr	3633	8	were	be	VBD
cord-006860-a3b8hyyr	3633	9	identified	identify	VBN
cord-006860-a3b8hyyr	3633	10	in	in	IN
cord-006860-a3b8hyyr	3633	11	the	the	DT
cord-006860-a3b8hyyr	3633	12	patients	patient	NNS
cord-006860-a3b8hyyr	3633	13	plasma	plasma	NN
cord-006860-a3b8hyyr	3633	14	.	.	.
cord-006860-a3b8hyyr	3634	1	By	by	IN
cord-006860-a3b8hyyr	3634	2	incubation	incubation	NN
cord-006860-a3b8hyyr	3634	3	of	of	IN
cord-006860-a3b8hyyr	3634	4	the	the	DT
cord-006860-a3b8hyyr	3634	5	patient	patient	NN
cord-006860-a3b8hyyr	3634	6	's	's	POS
cord-006860-a3b8hyyr	3634	7	serum	serum	NN
cord-006860-a3b8hyyr	3634	8	with	with	IN
cord-006860-a3b8hyyr	3634	9	platelets	platelet	NNS
cord-006860-a3b8hyyr	3634	10	of	of	IN
cord-006860-a3b8hyyr	3634	11	healthy	healthy	JJ
cord-006860-a3b8hyyr	3634	12	individuals	individual	NNS
cord-006860-a3b8hyyr	3634	13	,	,	,
cord-006860-a3b8hyyr	3634	14	platelet	platelet	NN
cord-006860-a3b8hyyr	3634	15	-	-	HYPH
cord-006860-a3b8hyyr	3634	16	clumping	clumping	NN
cord-006860-a3b8hyyr	3634	17	occurred	occur	VBD
cord-006860-a3b8hyyr	3634	18	in	in	IN
cord-006860-a3b8hyyr	3634	19	the	the	DT
cord-006860-a3b8hyyr	3634	20	presence	presence	NN
cord-006860-a3b8hyyr	3634	21	of	of	IN
cord-006860-a3b8hyyr	3634	22	Na	Na	NNP
cord-006860-a3b8hyyr	3634	23	-	-	HYPH
cord-006860-a3b8hyyr	3634	24	EDTA	EDTA	NNP
cord-006860-a3b8hyyr	3634	25	and	and	CC
cord-006860-a3b8hyyr	3634	26	sodium	sodium	NN
cord-006860-a3b8hyyr	3634	27	-	-	HYPH
cord-006860-a3b8hyyr	3634	28	citrate	citrate	NN
cord-006860-a3b8hyyr	3634	29	but	but	CC
cord-006860-a3b8hyyr	3634	30	not	not	RB
cord-006860-a3b8hyyr	3634	31	in	in	IN
cord-006860-a3b8hyyr	3634	32	the	the	DT
cord-006860-a3b8hyyr	3634	33	presence	presence	NN
cord-006860-a3b8hyyr	3634	34	of	of	IN
cord-006860-a3b8hyyr	3634	35	heparin	heparin	NN
cord-006860-a3b8hyyr	3634	36	.	.	.
cord-006860-a3b8hyyr	3635	1	The	the	DT
cord-006860-a3b8hyyr	3635	2	platelet	platelet	NN
cord-006860-a3b8hyyr	3635	3	membrane	membrane	NN
cord-006860-a3b8hyyr	3635	4	glycoproteins	glycoprotein	NNS
cord-006860-a3b8hyyr	3635	5	(	(	-LRB-
cord-006860-a3b8hyyr	3635	6	gp	gp	NN
cord-006860-a3b8hyyr	3635	7	)	)	-RRB-
cord-006860-a3b8hyyr	3636	1	Hb	Hb	NNP
cord-006860-a3b8hyyr	3636	2	/	/	SYM
cord-006860-a3b8hyyr	3636	3	llIa	llia	NN
cord-006860-a3b8hyyr	3636	4	,	,	,
cord-006860-a3b8hyyr	3636	5	IX	IX	NNP
cord-006860-a3b8hyyr	3636	6	and	and	CC
cord-006860-a3b8hyyr	3636	7	IIIa	IIIa	NNP
cord-006860-a3b8hyyr	3636	8	/	/	SYM
cord-006860-a3b8hyyr	3636	9	VNR	VNR	NNP
cord-006860-a3b8hyyr	3636	10	g	g	NNP
cord-006860-a3b8hyyr	3636	11	-	-	HYPH
cord-006860-a3b8hyyr	3636	12	chain	chain	NN
cord-006860-a3b8hyyr	3636	13	were	be	VBD
cord-006860-a3b8hyyr	3636	14	involved	involve	VBN
cord-006860-a3b8hyyr	3636	15	in	in	IN
cord-006860-a3b8hyyr	3636	16	the	the	DT
cord-006860-a3b8hyyr	3636	17	antigen	antigen	NN
cord-006860-a3b8hyyr	3636	18	antibody	antibody	NN
cord-006860-a3b8hyyr	3636	19	reaction	reaction	NN
cord-006860-a3b8hyyr	3636	20	as	as	IN
cord-006860-a3b8hyyr	3636	21	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	3636	22	by	by	IN
cord-006860-a3b8hyyr	3636	23	specific	specific	JJ
cord-006860-a3b8hyyr	3636	24	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3636	25	and	and	CC
cord-006860-a3b8hyyr	3636	26	flow	flow	NN
cord-006860-a3b8hyyr	3636	27	-	-	HYPH
cord-006860-a3b8hyyr	3636	28	cytometry	cytometry	NN
cord-006860-a3b8hyyr	3636	29	.	.	.
cord-006860-a3b8hyyr	3637	1	On	on	IN
cord-006860-a3b8hyyr	3637	2	platelet	platelet	NN
cord-006860-a3b8hyyr	3637	3	surface	surface	NN
cord-006860-a3b8hyyr	3637	4	permanent	permanent	JJ
cord-006860-a3b8hyyr	3637	5	calcium	calcium	NN
cord-006860-a3b8hyyr	3637	6	-	-	HYPH
cord-006860-a3b8hyyr	3637	7	exchange	exchange	NN
cord-006860-a3b8hyyr	3637	8	and	and	CC
cord-006860-a3b8hyyr	3637	9	-replacement	-replacement	NN
cord-006860-a3b8hyyr	3637	10	is	be	VBZ
cord-006860-a3b8hyyr	3637	11	dependent	dependent	JJ
cord-006860-a3b8hyyr	3637	12	on	on	IN
cord-006860-a3b8hyyr	3637	13	external	external	JJ
cord-006860-a3b8hyyr	3637	14	calcium	calcium	NN
cord-006860-a3b8hyyr	3637	15	concentration	concentration	NN
cord-006860-a3b8hyyr	3637	16	.	.	.
cord-006860-a3b8hyyr	3638	1	Calcium	calcium	NN
cord-006860-a3b8hyyr	3638	2	depletion	depletion	NN
cord-006860-a3b8hyyr	3638	3	induced	induce	VBN
cord-006860-a3b8hyyr	3638	4	by	by	IN
cord-006860-a3b8hyyr	3638	5	calcium	calcium	NN
cord-006860-a3b8hyyr	3638	6	chelators	chelator	NNS
cord-006860-a3b8hyyr	3638	7	as	as	IN
cord-006860-a3b8hyyr	3638	8	Na	Na	NNP
cord-006860-a3b8hyyr	3638	9	-	-	HYPH
cord-006860-a3b8hyyr	3638	10	EDTA	EDTA	NNP
cord-006860-a3b8hyyr	3638	11	and	and	CC
cord-006860-a3b8hyyr	3638	12	sodium	sodium	NN
cord-006860-a3b8hyyr	3638	13	-	-	HYPH
cord-006860-a3b8hyyr	3638	14	citrate	citrate	NN
cord-006860-a3b8hyyr	3638	15	might	may	MD
cord-006860-a3b8hyyr	3638	16	conformationally	conformationally	RB
cord-006860-a3b8hyyr	3638	17	change	change	VB
cord-006860-a3b8hyyr	3638	18	platelet	platelet	NN
cord-006860-a3b8hyyr	3638	19	surfaces	surface	NNS
cord-006860-a3b8hyyr	3638	20	and	and	CC
cord-006860-a3b8hyyr	3638	21	induce	induce	VB
cord-006860-a3b8hyyr	3638	22	formation	formation	NN
cord-006860-a3b8hyyr	3638	23	of	of	IN
cord-006860-a3b8hyyr	3638	24	neoantigens	neoantigen	NNS
cord-006860-a3b8hyyr	3638	25	.	.	.
cord-006860-a3b8hyyr	3639	1	The	the	DT
cord-006860-a3b8hyyr	3639	2	decrease	decrease	NN
cord-006860-a3b8hyyr	3639	3	of	of	IN
cord-006860-a3b8hyyr	3639	4	gp	gp	NNP
cord-006860-a3b8hyyr	3639	5	llb	llb	NNP
cord-006860-a3b8hyyr	3639	6	/	/	,
cord-006860-a3b8hyyr	3639	7	Illa	Illa	NNP
cord-006860-a3b8hyyr	3639	8	platelet	platelet	NN
cord-006860-a3b8hyyr	3639	9	surface	surface	NN
cord-006860-a3b8hyyr	3639	10	antigen	antigen	NN
cord-006860-a3b8hyyr	3639	11	to	to	IN
cord-006860-a3b8hyyr	3639	12	10	10	CD
cord-006860-a3b8hyyr	3639	13	%	%	NN
cord-006860-a3b8hyyr	3639	14	(	(	-LRB-
cord-006860-a3b8hyyr	3639	15	normal	normal	JJ
cord-006860-a3b8hyyr	3639	16	>	>	XX
cord-006860-a3b8hyyr	3639	17	75	75	CD
cord-006860-a3b8hyyr	3639	18	%	%	NN
cord-006860-a3b8hyyr	3639	19	)	)	-RRB-
cord-006860-a3b8hyyr	3639	20	indicated	indicate	VBD
cord-006860-a3b8hyyr	3639	21	the	the	DT
cord-006860-a3b8hyyr	3639	22	important	important	JJ
cord-006860-a3b8hyyr	3639	23	role	role	NN
cord-006860-a3b8hyyr	3639	24	of	of	IN
cord-006860-a3b8hyyr	3639	25	the	the	DT
cord-006860-a3b8hyyr	3639	26	gp	gp	NNP
cord-006860-a3b8hyyr	3639	27	IIb	IIb	NNP
cord-006860-a3b8hyyr	3639	28	/	/	SYM
cord-006860-a3b8hyyr	3639	29	IIIa	iiia	NN
cord-006860-a3b8hyyr	3639	30	receptor	receptor	NN
cord-006860-a3b8hyyr	3639	31	at	at	IN
cord-006860-a3b8hyyr	3639	32	PTCP	PTCP	NNP
cord-006860-a3b8hyyr	3639	33	.	.	.
cord-006860-a3b8hyyr	3640	1	The	the	DT
cord-006860-a3b8hyyr	3640	2	saliva	saliva	NN
cord-006860-a3b8hyyr	3640	3	of	of	IN
cord-006860-a3b8hyyr	3640	4	Tdatoma	Tdatoma	NNP
cord-006860-a3b8hyyr	3640	5	pallidipennis	pallidipennis	NNP
cord-006860-a3b8hyyr	3640	6	,	,	,
cord-006860-a3b8hyyr	3640	7	a	a	DT
cord-006860-a3b8hyyr	3640	8	triatomine	triatomine	JJ
cord-006860-a3b8hyyr	3640	9	bug	bug	NN
cord-006860-a3b8hyyr	3640	10	,	,	,
cord-006860-a3b8hyyr	3640	11	was	be	VBD
cord-006860-a3b8hyyr	3640	12	found	find	VBN
cord-006860-a3b8hyyr	3640	13	to	to	TO
cord-006860-a3b8hyyr	3640	14	contain	contain	VB
cord-006860-a3b8hyyr	3640	15	a	a	DT
cord-006860-a3b8hyyr	3640	16	protein	protein	NN
cord-006860-a3b8hyyr	3640	17	called	call	VBN
cord-006860-a3b8hyyr	3640	18	"	"	``
cord-006860-a3b8hyyr	3640	19	pallidipin	pallidipin	NNP
cord-006860-a3b8hyyr	3640	20	"	"	''
cord-006860-a3b8hyyr	3640	21	,	,	,
cord-006860-a3b8hyyr	3640	22	that	that	WDT
cord-006860-a3b8hyyr	3640	23	specifically	specifically	RB
cord-006860-a3b8hyyr	3640	24	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	3640	25	collageninduced	collageninduced	JJ
cord-006860-a3b8hyyr	3640	26	platelet	platelet	NN
cord-006860-a3b8hyyr	3640	27	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3640	28	but	but	CC
cord-006860-a3b8hyyr	3640	29	not	not	RB
cord-006860-a3b8hyyr	3640	30	adhesion	adhesion	NN
cord-006860-a3b8hyyr	3640	31	or	or	CC
cord-006860-a3b8hyyr	3640	32	shape	shape	NN
cord-006860-a3b8hyyr	3640	33	change	change	NN
cord-006860-a3b8hyyr	3640	34	.	.	.
cord-006860-a3b8hyyr	3641	1	To	to	TO
cord-006860-a3b8hyyr	3641	2	investigate	investigate	VB
cord-006860-a3b8hyyr	3641	3	the	the	DT
cord-006860-a3b8hyyr	3641	4	mechanism	mechanism	NN
cord-006860-a3b8hyyr	3641	5	of	of	IN
cord-006860-a3b8hyyr	3641	6	action	action	NN
cord-006860-a3b8hyyr	3641	7	of	of	IN
cord-006860-a3b8hyyr	3641	8	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	3641	9	pallidipin	pallidipin	NNP
cord-006860-a3b8hyyr	3641	10	the	the	DT
cord-006860-a3b8hyyr	3641	11	influence	influence	NN
cord-006860-a3b8hyyr	3641	12	on	on	IN
cord-006860-a3b8hyyr	3641	13	platelet	platelet	NN
cord-006860-a3b8hyyr	3641	14	fibdnogen	fibdnogen	NN
cord-006860-a3b8hyyr	3641	15	binding	bind	VBG
cord-006860-a3b8hyyr	3641	16	after	after	IN
cord-006860-a3b8hyyr	3641	17	activation	activation	NN
cord-006860-a3b8hyyr	3641	18	by	by	IN
cord-006860-a3b8hyyr	3641	19	collagen	collagen	NN
cord-006860-a3b8hyyr	3641	20	type	type	NN
cord-006860-a3b8hyyr	3641	21	I	-PRON-	PRP
cord-006860-a3b8hyyr	3641	22	in	in	IN
cord-006860-a3b8hyyr	3641	23	different	different	JJ
cord-006860-a3b8hyyr	3641	24	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3641	25	was	be	VBD
cord-006860-a3b8hyyr	3641	26	measured	measure	VBN
cord-006860-a3b8hyyr	3641	27	by	by	IN
cord-006860-a3b8hyyr	3641	28	flow	flow	NN
cord-006860-a3b8hyyr	3641	29	cytometry	cytometry	NN
cord-006860-a3b8hyyr	3641	30	.	.	.
cord-006860-a3b8hyyr	3642	1	The	the	DT
cord-006860-a3b8hyyr	3642	2	same	same	JJ
cord-006860-a3b8hyyr	3642	3	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3642	4	of	of	IN
cord-006860-a3b8hyyr	3642	5	pallidipin	pallidipin	NN
cord-006860-a3b8hyyr	3642	6	that	that	WDT
cord-006860-a3b8hyyr	3642	7	inhibited	inhibit	VBD
cord-006860-a3b8hyyr	3642	8	the	the	DT
cord-006860-a3b8hyyr	3642	9	coUagen	couagen	NN
cord-006860-a3b8hyyr	3642	10	-	-	HYPH
cord-006860-a3b8hyyr	3642	11	induced	induce	VBN
cord-006860-a3b8hyyr	3642	12	platelet	platelet	NN
cord-006860-a3b8hyyr	3642	13	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3642	14	completely	completely	RB
cord-006860-a3b8hyyr	3642	15	did	do	VBD
cord-006860-a3b8hyyr	3642	16	not	not	RB
cord-006860-a3b8hyyr	3642	17	cause	cause	VB
cord-006860-a3b8hyyr	3642	18	any	any	DT
cord-006860-a3b8hyyr	3642	19	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	3642	20	effect	effect	NN
cord-006860-a3b8hyyr	3642	21	on	on	IN
cord-006860-a3b8hyyr	3642	22	fibdnogen	fibdnogen	NN
cord-006860-a3b8hyyr	3642	23	-	-	HYPH
cord-006860-a3b8hyyr	3642	24	binding	binding	NN
cord-006860-a3b8hyyr	3642	25	in	in	IN
cord-006860-a3b8hyyr	3642	26	the	the	DT
cord-006860-a3b8hyyr	3642	27	PRP	prp	NN
cord-006860-a3b8hyyr	3642	28	from	from	IN
cord-006860-a3b8hyyr	3642	29	the	the	DT
cord-006860-a3b8hyyr	3642	30	same	same	JJ
cord-006860-a3b8hyyr	3642	31	donor	donor	NN
cord-006860-a3b8hyyr	3642	32	measured	measure	VBN
cord-006860-a3b8hyyr	3642	33	contemporaryly	contemporaryly	NNP
cord-006860-a3b8hyyr	3642	34	.	.	.
cord-006860-a3b8hyyr	3643	1	Collagen	collagen	NN
cord-006860-a3b8hyyr	3643	2	type	type	NN
cord-006860-a3b8hyyr	3643	3	I	i	NN
cord-006860-a3b8hyyr	3643	4	-	-	HYPH
cord-006860-a3b8hyyr	3643	5	induced	induce	VBN
cord-006860-a3b8hyyr	3643	6	platelet	platelet	NN
cord-006860-a3b8hyyr	3643	7	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3643	8	of	of	IN
cord-006860-a3b8hyyr	3643	9	CD36-deficient	CD36-deficient	NNP
cord-006860-a3b8hyyr	3643	10	platelets	platelet	NNS
cord-006860-a3b8hyyr	3643	11	from	from	IN
cord-006860-a3b8hyyr	3643	12	two	two	CD
cord-006860-a3b8hyyr	3643	13	different	different	JJ
cord-006860-a3b8hyyr	3643	14	unrelated	unrelated	JJ
cord-006860-a3b8hyyr	3643	15	blood	blood	NN
cord-006860-a3b8hyyr	3643	16	donors	donor	NNS
cord-006860-a3b8hyyr	3643	17	was	be	VBD
cord-006860-a3b8hyyr	3643	18	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	3643	19	by	by	IN
cord-006860-a3b8hyyr	3643	20	the	the	DT
cord-006860-a3b8hyyr	3643	21	same	same	JJ
cord-006860-a3b8hyyr	3643	22	concentration	concentration	NN
cord-006860-a3b8hyyr	3643	23	of	of	IN
cord-006860-a3b8hyyr	3643	24	pallidipin	pallidipin	NNP
cord-006860-a3b8hyyr	3643	25	that	that	WDT
cord-006860-a3b8hyyr	3643	26	inhibited	inhibit	VBD
cord-006860-a3b8hyyr	3643	27	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3643	28	of	of	IN
cord-006860-a3b8hyyr	3643	29	control	control	NN
cord-006860-a3b8hyyr	3643	30	platelets	platelet	NNS
cord-006860-a3b8hyyr	3643	31	.	.	.
cord-006860-a3b8hyyr	3644	1	There	there	EX
cord-006860-a3b8hyyr	3644	2	was	be	VBD
cord-006860-a3b8hyyr	3644	3	no	no	DT
cord-006860-a3b8hyyr	3644	4	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3644	5	of	of	IN
cord-006860-a3b8hyyr	3644	6	collagen	collagen	NN
cord-006860-a3b8hyyr	3644	7	-	-	HYPH
cord-006860-a3b8hyyr	3644	8	induced	induce	VBN
cord-006860-a3b8hyyr	3644	9	fibdnogen	fibdnogen	NN
cord-006860-a3b8hyyr	3644	10	-	-	HYPH
cord-006860-a3b8hyyr	3644	11	binding	binding	NN
cord-006860-a3b8hyyr	3644	12	in	in	IN
cord-006860-a3b8hyyr	3644	13	the	the	DT
cord-006860-a3b8hyyr	3644	14	CD36-deficient	CD36-deficient	NNP
cord-006860-a3b8hyyr	3644	15	platelets	platelet	NNS
cord-006860-a3b8hyyr	3644	16	as	as	RB
cord-006860-a3b8hyyr	3644	17	well	well	RB
cord-006860-a3b8hyyr	3644	18	.	.	.
cord-006860-a3b8hyyr	3645	1	Pallidipin	Pallidipin	NNP
cord-006860-a3b8hyyr	3645	2	did	do	VBD
cord-006860-a3b8hyyr	3645	3	not	not	RB
cord-006860-a3b8hyyr	3645	4	cause	cause	VB
cord-006860-a3b8hyyr	3645	5	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3645	6	of	of	IN
cord-006860-a3b8hyyr	3645	7	collagen	collagen	NN
cord-006860-a3b8hyyr	3645	8	-	-	HYPH
cord-006860-a3b8hyyr	3645	9	induced	induce	VBN
cord-006860-a3b8hyyr	3645	10	membrane	membrane	NN
cord-006860-a3b8hyyr	3645	11	expression	expression	NN
cord-006860-a3b8hyyr	3645	12	of	of	IN
cord-006860-a3b8hyyr	3645	13	CD62	CD62	NNP
cord-006860-a3b8hyyr	3645	14	and	and	CC
cord-006860-a3b8hyyr	3645	15	CD63	CD63	NNP
cord-006860-a3b8hyyr	3645	16	of	of	IN
cord-006860-a3b8hyyr	3645	17	control	control	NN
cord-006860-a3b8hyyr	3645	18	and	and	CC
cord-006860-a3b8hyyr	3645	19	CD36-deflcient	CD36-deflcient	NNP
cord-006860-a3b8hyyr	3645	20	platetets	platetet	NNS
cord-006860-a3b8hyyr	3645	21	as	as	IN
cord-006860-a3b8hyyr	3645	22	measured	measure	VBN
cord-006860-a3b8hyyr	3645	23	by	by	IN
cord-006860-a3b8hyyr	3645	24	flow	flow	NN
cord-006860-a3b8hyyr	3645	25	cytometry	cytometry	NN
cord-006860-a3b8hyyr	3645	26	.	.	.
cord-006860-a3b8hyyr	3646	1	However	however	RB
cord-006860-a3b8hyyr	3646	2	eadier	eadier	NNP
cord-006860-a3b8hyyr	3646	3	studies	study	NNS
cord-006860-a3b8hyyr	3646	4	had	have	VBD
cord-006860-a3b8hyyr	3646	5	shown	show	VBN
cord-006860-a3b8hyyr	3646	6	an	an	DT
cord-006860-a3b8hyyr	3646	7	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3646	8	of	of	IN
cord-006860-a3b8hyyr	3646	9	collagen	collagen	NN
cord-006860-a3b8hyyr	3646	10	-	-	HYPH
cord-006860-a3b8hyyr	3646	11	induced	induce	VBN
cord-006860-a3b8hyyr	3646	12	ATP	ATP	NNP
cord-006860-a3b8hyyr	3646	13	and	and	CC
cord-006860-a3b8hyyr	3646	14	{	{	-LRB-
cord-006860-a3b8hyyr	3646	15	3Tg	3tg	JJ
cord-006860-a3b8hyyr	3646	16	secretion	secretion	NN
cord-006860-a3b8hyyr	3646	17	by	by	IN
cord-006860-a3b8hyyr	3646	18	pallidipin	pallidipin	NNP
cord-006860-a3b8hyyr	3646	19	.	.	.
cord-006860-a3b8hyyr	3647	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	3647	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	3647	3	compared	compare	VBD
cord-006860-a3b8hyyr	3647	4	the	the	DT
cord-006860-a3b8hyyr	3647	5	effect	effect	NN
cord-006860-a3b8hyyr	3647	6	of	of	IN
cord-006860-a3b8hyyr	3647	7	pallidipin	pallidipin	NN
cord-006860-a3b8hyyr	3647	8	in	in	IN
cord-006860-a3b8hyyr	3647	9	unstirred	unstirred	JJ
cord-006860-a3b8hyyr	3647	10	and	and	CC
cord-006860-a3b8hyyr	3647	11	stirred	stir	VBD
cord-006860-a3b8hyyr	3647	12	PRP	PRP	NNP
cord-006860-a3b8hyyr	3647	13	samples	sample	NNS
cord-006860-a3b8hyyr	3647	14	.	.	.
cord-006860-a3b8hyyr	3648	1	While	while	IN
cord-006860-a3b8hyyr	3648	2	pallidipin	pallidipin	NNP
cord-006860-a3b8hyyr	3648	3	had	have	VBD
cord-006860-a3b8hyyr	3648	4	no	no	DT
cord-006860-a3b8hyyr	3648	5	effect	effect	NN
cord-006860-a3b8hyyr	3648	6	in	in	IN
cord-006860-a3b8hyyr	3648	7	unstirred	unstirred	JJ
cord-006860-a3b8hyyr	3648	8	samples	sample	NNS
cord-006860-a3b8hyyr	3648	9	it	-PRON-	PRP
cord-006860-a3b8hyyr	3648	10	showed	show	VBD
cord-006860-a3b8hyyr	3648	11	strong	strong	JJ
cord-006860-a3b8hyyr	3648	12	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3648	13	of	of	IN
cord-006860-a3b8hyyr	3648	14	pTg	ptg	JJ
cord-006860-a3b8hyyr	3648	15	secretion	secretion	NN
cord-006860-a3b8hyyr	3648	16	in	in	IN
cord-006860-a3b8hyyr	3648	17	stirred	stir	VBN
cord-006860-a3b8hyyr	3648	18	samples	sample	NNS
cord-006860-a3b8hyyr	3648	19	.	.	.
cord-006860-a3b8hyyr	3649	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3649	2	therefore	therefore	RB
cord-006860-a3b8hyyr	3649	3	conclude	conclude	VBP
cord-006860-a3b8hyyr	3649	4	that	that	IN
cord-006860-a3b8hyyr	3649	5	pallidipin	pallidipin	NNP
cord-006860-a3b8hyyr	3649	6	does	do	VBZ
cord-006860-a3b8hyyr	3649	7	not	not	RB
cord-006860-a3b8hyyr	3649	8	act	act	VB
cord-006860-a3b8hyyr	3649	9	on	on	IN
cord-006860-a3b8hyyr	3649	10	collagen	collagen	NN
cord-006860-a3b8hyyr	3649	11	-	-	HYPH
cord-006860-a3b8hyyr	3649	12	induced	induce	VBN
cord-006860-a3b8hyyr	3649	13	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3649	14	through	through	IN
cord-006860-a3b8hyyr	3649	15	CD36	CD36	NNP
cord-006860-a3b8hyyr	3649	16	and	and	CC
cord-006860-a3b8hyyr	3649	17	that	that	IN
cord-006860-a3b8hyyr	3649	18	the	the	DT
cord-006860-a3b8hyyr	3649	19	inhibition	inhibition	NN
cord-006860-a3b8hyyr	3649	20	is	be	VBZ
cord-006860-a3b8hyyr	3649	21	a	a	DT
cord-006860-a3b8hyyr	3649	22	post	post	JJ
cord-006860-a3b8hyyr	3649	23	fibdnogenbinding	fibdnogenbinding	NN
cord-006860-a3b8hyyr	3649	24	event	event	NN
cord-006860-a3b8hyyr	3649	25	.	.	.
cord-006860-a3b8hyyr	3650	1	Pallidipin	Pallidipin	NNP
cord-006860-a3b8hyyr	3650	2	does	do	VBZ
cord-006860-a3b8hyyr	3650	3	not	not	RB
cord-006860-a3b8hyyr	3650	4	influence	influence	VB
cord-006860-a3b8hyyr	3650	5	the	the	DT
cord-006860-a3b8hyyr	3650	6	first	first	JJ
cord-006860-a3b8hyyr	3650	7	steps	step	NNS
cord-006860-a3b8hyyr	3650	8	in	in	IN
cord-006860-a3b8hyyr	3650	9	secretion	secretion	NN
cord-006860-a3b8hyyr	3650	10	,	,	,
cord-006860-a3b8hyyr	3650	11	which	which	WDT
cord-006860-a3b8hyyr	3650	12	are	be	VBP
cord-006860-a3b8hyyr	3650	13	independent	independent	JJ
cord-006860-a3b8hyyr	3650	14	from	from	IN
cord-006860-a3b8hyyr	3650	15	cytoskeleton	cytoskeleton	NN
cord-006860-a3b8hyyr	3650	16	and	and	CC
cord-006860-a3b8hyyr	3650	17	platelet	platelet	NN
cord-006860-a3b8hyyr	3650	18	-	-	HYPH
cord-006860-a3b8hyyr	3650	19	platelet	platelet	NN
cord-006860-a3b8hyyr	3650	20	contact	contact	NN
cord-006860-a3b8hyyr	3650	21	,	,	,
cord-006860-a3b8hyyr	3650	22	but	but	CC
cord-006860-a3b8hyyr	3650	23	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	3650	24	the	the	DT
cord-006860-a3b8hyyr	3650	25	following	follow	VBG
cord-006860-a3b8hyyr	3650	26	steps	step	NNS
cord-006860-a3b8hyyr	3650	27	.	.	.
cord-006860-a3b8hyyr	3651	1	17-HYDROXY	17-hydroxy	LS
cord-006860-a3b8hyyr	3651	2	-	-	:
cord-006860-a3b8hyyr	3651	3	WORTMANNIN	wortmannin	NN
cord-006860-a3b8hyyr	3651	4	DOES	do	VBZ
cord-006860-a3b8hyyr	3651	5	NOT	not	RB
cord-006860-a3b8hyyr	3651	6	iNHiBiT	inhibit	VB
cord-006860-a3b8hyyr	3652	1	THE	the	DT
cord-006860-a3b8hyyr	3652	2	TRANSPORT	transport	NN
cord-006860-a3b8hyyr	3652	3	OF	of	IN
cord-006860-a3b8hyyr	3652	4	1NM	1nm	CD
cord-006860-a3b8hyyr	3652	5	-	-	HYPH
cord-006860-a3b8hyyr	3652	6	GOLD	gold	NN
cord-006860-a3b8hyyr	3652	7	LABELLED	LABELLED	NNP
cord-006860-a3b8hyyr	3652	8	FIBRINOGEN	fibrinogen	NN
cord-006860-a3b8hyyr	3652	9	IN	in	IN
cord-006860-a3b8hyyr	3652	10	RESTING	rest	VBG
cord-006860-a3b8hyyr	3652	11	PLATELETS	platelets	NN
cord-006860-a3b8hyyr	3652	12	.	.	.
cord-006860-a3b8hyyr	3653	1	E.	E.	NNP
cord-006860-a3b8hyyr	3653	2	Morgenstem	Morgenstem	NNP
cord-006860-a3b8hyyr	3653	3	,	,	,
cord-006860-a3b8hyyr	3653	4	B.	B.	NNP
cord-006860-a3b8hyyr	3653	5	Kehrel	Kehrel	NNP
cord-006860-a3b8hyyr	3653	6	and	and	CC
cord-006860-a3b8hyyr	3653	7	K.J.	K.J.	NNP
cord-006860-a3b8hyyr	3653	8	Clemetson	Clemetson	NNP
cord-006860-a3b8hyyr	3653	9	Medical	Medical	NNP
cord-006860-a3b8hyyr	3653	10	Biology	Biology	NNP
cord-006860-a3b8hyyr	3653	11	,	,	,
cord-006860-a3b8hyyr	3654	1	Saarland	Saarland	NNP
cord-006860-a3b8hyyr	3654	2	Univ	Univ	NNP
cord-006860-a3b8hyyr	3654	3	.	.	NNP
cord-006860-a3b8hyyr	3654	4	,	,	,
cord-006860-a3b8hyyr	3654	5	Homburg	Homburg	NNP
cord-006860-a3b8hyyr	3654	6	,	,	,
cord-006860-a3b8hyyr	3654	7	Germany	Germany	NNP
cord-006860-a3b8hyyr	3654	8	,	,	,
cord-006860-a3b8hyyr	3654	9	Haemostasis	Haemostasis	NNP
cord-006860-a3b8hyyr	3654	10	Research	Research	NNP
cord-006860-a3b8hyyr	3654	11	,	,	,
cord-006860-a3b8hyyr	3654	12	Univ	Univ	NNP
cord-006860-a3b8hyyr	3654	13	.	.	.
cord-006860-a3b8hyyr	3655	1	Muenster	Muenster	NNP
cord-006860-a3b8hyyr	3655	2	,	,	,
cord-006860-a3b8hyyr	3655	3	Germany	Germany	NNP
cord-006860-a3b8hyyr	3655	4	and	and	CC
cord-006860-a3b8hyyr	3655	5	Theedor	Theedor	NNP
cord-006860-a3b8hyyr	3655	6	-	-	HYPH
cord-006860-a3b8hyyr	3655	7	Kocher	Kocher	NNP
cord-006860-a3b8hyyr	3655	8	-	-	HYPH
cord-006860-a3b8hyyr	3655	9	lnstitut	lnstitut	NNP
cord-006860-a3b8hyyr	3655	10	,	,	,
cord-006860-a3b8hyyr	3655	11	Univ	Univ	NNP
cord-006860-a3b8hyyr	3655	12	.	.	.
cord-006860-a3b8hyyr	3656	1	Bern	Bern	NNP
cord-006860-a3b8hyyr	3656	2	,	,	,
cord-006860-a3b8hyyr	3656	3	Switzerland	Switzerland	NNP
cord-006860-a3b8hyyr	3656	4	.	.	.
cord-006860-a3b8hyyr	3657	1	Wortmannin	Wortmannin	NNP
cord-006860-a3b8hyyr	3657	2	,	,	,
cord-006860-a3b8hyyr	3657	3	an	an	DT
cord-006860-a3b8hyyr	3657	4	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3657	5	of	of	IN
cord-006860-a3b8hyyr	3657	6	phosphoinositide	phosphoinositide	JJ
cord-006860-a3b8hyyr	3657	7	3-kinase	3-kinase	CD
cord-006860-a3b8hyyr	3657	8	and	and	CC
cord-006860-a3b8hyyr	3657	9	of	of	IN
cord-006860-a3b8hyyr	3657	10	myosin	myosin	NN
cord-006860-a3b8hyyr	3657	11	light	light	JJ
cord-006860-a3b8hyyr	3657	12	chain	chain	NN
cord-006860-a3b8hyyr	3657	13	kinase	kinase	NN
cord-006860-a3b8hyyr	3657	14	blocks	block	VBZ
cord-006860-a3b8hyyr	3657	15	reactions	reaction	NNS
cord-006860-a3b8hyyr	3657	16	of	of	IN
cord-006860-a3b8hyyr	3657	17	the	the	DT
cord-006860-a3b8hyyr	3657	18	activated	activate	VBN
cord-006860-a3b8hyyr	3657	19	platelet	platelet	NN
cord-006860-a3b8hyyr	3657	20	.	.	.
cord-006860-a3b8hyyr	3658	1	To	to	TO
cord-006860-a3b8hyyr	3658	2	obtain	obtain	VB
cord-006860-a3b8hyyr	3658	3	informations	information	NNS
cord-006860-a3b8hyyr	3658	4	about	about	IN
cord-006860-a3b8hyyr	3658	5	the	the	DT
cord-006860-a3b8hyyr	3658	6	role	role	NN
cord-006860-a3b8hyyr	3658	7	of	of	IN
cord-006860-a3b8hyyr	3658	8	the	the	DT
cord-006860-a3b8hyyr	3658	9	contractile	contractile	JJ
cord-006860-a3b8hyyr	3658	10	cytoskeleton	cytoskeleton	NN
cord-006860-a3b8hyyr	3658	11	in	in	IN
cord-006860-a3b8hyyr	3658	12	receptor	receptor	NN
cord-006860-a3b8hyyr	3658	13	-	-	HYPH
cord-006860-a3b8hyyr	3658	14	mediated	mediate	VBN
cord-006860-a3b8hyyr	3658	15	transport	transport	NN
cord-006860-a3b8hyyr	3658	16	of	of	IN
cord-006860-a3b8hyyr	3658	17	resting	rest	VBG
cord-006860-a3b8hyyr	3658	18	platelets	platelet	NNS
cord-006860-a3b8hyyr	3658	19	,	,	,
cord-006860-a3b8hyyr	3658	20	the	the	DT
cord-006860-a3b8hyyr	3658	21	effect	effect	NN
cord-006860-a3b8hyyr	3658	22	of	of	IN
cord-006860-a3b8hyyr	3658	23	17-hydroxy	17-hydroxy	CD
cord-006860-a3b8hyyr	3658	24	-	-	HYPH
cord-006860-a3b8hyyr	3658	25	Wodmannin	Wodmannin	NNP
cord-006860-a3b8hyyr	3658	26	(	(	-LRB-
cord-006860-a3b8hyyr	3658	27	HW	HW	NNP
cord-006860-a3b8hyyr	3658	28	)	)	-RRB-
cord-006860-a3b8hyyr	3658	29	on	on	IN
cord-006860-a3b8hyyr	3658	30	the	the	DT
cord-006860-a3b8hyyr	3658	31	endocytosis	endocytosis	NN
cord-006860-a3b8hyyr	3658	32	of	of	IN
cord-006860-a3b8hyyr	3658	33	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3658	34	from	from	IN
cord-006860-a3b8hyyr	3658	35	the	the	DT
cord-006860-a3b8hyyr	3658	36	surface	surface	NN
cord-006860-a3b8hyyr	3658	37	of	of	IN
cord-006860-a3b8hyyr	3658	38	resting	rest	VBG
cord-006860-a3b8hyyr	3658	39	platelets	platelet	NNS
cord-006860-a3b8hyyr	3658	40	was	be	VBD
cord-006860-a3b8hyyr	3658	41	studied	study	VBN
cord-006860-a3b8hyyr	3658	42	.	.	.
cord-006860-a3b8hyyr	3659	1	Gel	gel	NN
cord-006860-a3b8hyyr	3659	2	filtered	filter	VBN
cord-006860-a3b8hyyr	3659	3	platelets	platelet	NNS
cord-006860-a3b8hyyr	3659	4	(	(	-LRB-
cord-006860-a3b8hyyr	3659	5	GFP	GFP	NNP
cord-006860-a3b8hyyr	3659	6	)	)	-RRB-
cord-006860-a3b8hyyr	3659	7	were	be	VBD
cord-006860-a3b8hyyr	3659	8	incubated	incubate	VBN
cord-006860-a3b8hyyr	3659	9	for	for	IN
cord-006860-a3b8hyyr	3659	10	10	10	CD
cord-006860-a3b8hyyr	3659	11	min	min	NN
cord-006860-a3b8hyyr	3659	12	at	at	IN
cord-006860-a3b8hyyr	3659	13	37	37	CD
cord-006860-a3b8hyyr	3659	14	°	°	NN
cord-006860-a3b8hyyr	3659	15	C	c	NN
cord-006860-a3b8hyyr	3659	16	with	with	IN
cord-006860-a3b8hyyr	3659	17	HW	HW	NNP
cord-006860-a3b8hyyr	3659	18	(	(	-LRB-
cord-006860-a3b8hyyr	3659	19	3x10	3x10	CD
cord-006860-a3b8hyyr	3659	20	-	-	SYM
cord-006860-a3b8hyyr	3659	21	6	6	CD
cord-006860-a3b8hyyr	3659	22	M	M	NNP
cord-006860-a3b8hyyr	3659	23	)	)	-RRB-
cord-006860-a3b8hyyr	3659	24	or	or	CC
cord-006860-a3b8hyyr	3659	25	with	with	IN
cord-006860-a3b8hyyr	3659	26	Iloprost	Iloprost	NNP
cord-006860-a3b8hyyr	3659	27	.	.	.
cord-006860-a3b8hyyr	3660	1	Controls	control	NNS
cord-006860-a3b8hyyr	3660	2	and	and	CC
cord-006860-a3b8hyyr	3660	3	GFP	GFP	NNP
cord-006860-a3b8hyyr	3660	4	preincubated	preincubate	VBD
cord-006860-a3b8hyyr	3660	5	with	with	IN
cord-006860-a3b8hyyr	3660	6	HW	HW	NNP
cord-006860-a3b8hyyr	3660	7	or	or	CC
cord-006860-a3b8hyyr	3660	8	Ilopmst	Ilopmst	NNPS
cord-006860-a3b8hyyr	3660	9	were	be	VBD
cord-006860-a3b8hyyr	3660	10	incubated	incubate	VBN
cord-006860-a3b8hyyr	3660	11	with	with	IN
cord-006860-a3b8hyyr	3660	12	1.4nm	1.4nm	CD
cord-006860-a3b8hyyr	3660	13	-	-	HYPH
cord-006860-a3b8hyyr	3660	14	gold	gold	NN
cord-006860-a3b8hyyr	3660	15	labelled	label	VBN
cord-006860-a3b8hyyr	3660	16	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3660	17	molecules	molecule	NNS
cord-006860-a3b8hyyr	3660	18	(	(	-LRB-
cord-006860-a3b8hyyr	3660	19	Fg	Fg	NNP
cord-006860-a3b8hyyr	3660	20	-	-	HYPH
cord-006860-a3b8hyyr	3660	21	Au	Au	NNP
cord-006860-a3b8hyyr	3660	22	;	;	,
cord-006860-a3b8hyyr	3660	23	final	final	JJ
cord-006860-a3b8hyyr	3660	24	concentration	concentration	NN
cord-006860-a3b8hyyr	3660	25	40p.g	40p.g	CD
cord-006860-a3b8hyyr	3660	26	/	/	SYM
cord-006860-a3b8hyyr	3660	27	ml	ml	NN
cord-006860-a3b8hyyr	3660	28	)	)	-RRB-
cord-006860-a3b8hyyr	3660	29	at	at	IN
cord-006860-a3b8hyyr	3660	30	37	37	CD
cord-006860-a3b8hyyr	3660	31	°	°	NN
cord-006860-a3b8hyyr	3660	32	C	c	NN
cord-006860-a3b8hyyr	3660	33	.	.	.
cord-006860-a3b8hyyr	3661	1	The	the	DT
cord-006860-a3b8hyyr	3661	2	experiments	experiment	NNS
cord-006860-a3b8hyyr	3661	3	were	be	VBD
cord-006860-a3b8hyyr	3661	4	stopped	stop	VBN
cord-006860-a3b8hyyr	3661	5	after	after	IN
cord-006860-a3b8hyyr	3661	6	5	5	CD
cord-006860-a3b8hyyr	3661	7	or	or	CC
cord-006860-a3b8hyyr	3661	8	30	30	CD
cord-006860-a3b8hyyr	3661	9	min	min	NN
cord-006860-a3b8hyyr	3661	10	by	by	IN
cord-006860-a3b8hyyr	3661	11	rapid	rapid	JJ
cord-006860-a3b8hyyr	3661	12	freezing	freezing	NN
cord-006860-a3b8hyyr	3661	13	.	.	.
cord-006860-a3b8hyyr	3662	1	After	after	IN
cord-006860-a3b8hyyr	3662	2	freeze	freeze	VB
cord-006860-a3b8hyyr	3662	3	substitution	substitution	NN
cord-006860-a3b8hyyr	3662	4	in	in	IN
cord-006860-a3b8hyyr	3662	5	acetone	acetone	NN
cord-006860-a3b8hyyr	3662	6	with	with	IN
cord-006860-a3b8hyyr	3662	7	4	4	CD
cord-006860-a3b8hyyr	3662	8	%	%	NN
cord-006860-a3b8hyyr	3662	9	osmiumtetroxide	osmiumtetroxide	JJ
cord-006860-a3b8hyyr	3662	10	,	,	,
cord-006860-a3b8hyyr	3662	11	sedal	sedal	JJ
cord-006860-a3b8hyyr	3662	12	sections	section	NNS
cord-006860-a3b8hyyr	3662	13	were	be	VBD
cord-006860-a3b8hyyr	3662	14	prepared	prepare	VBN
cord-006860-a3b8hyyr	3662	15	.	.	.
cord-006860-a3b8hyyr	3663	1	The	the	DT
cord-006860-a3b8hyyr	3663	2	sections	section	NNS
cord-006860-a3b8hyyr	3663	3	were	be	VBD
cord-006860-a3b8hyyr	3663	4	examined	examine	VBN
cord-006860-a3b8hyyr	3663	5	after	after	IN
cord-006860-a3b8hyyr	3663	6	incubation	incubation	NN
cord-006860-a3b8hyyr	3663	7	with	with	IN
cord-006860-a3b8hyyr	3663	8	ascorbic	ascorbic	NN
cord-006860-a3b8hyyr	3663	9	acid	acid	NN
cord-006860-a3b8hyyr	3663	10	(	(	-LRB-
cord-006860-a3b8hyyr	3663	11	5	5	CD
cord-006860-a3b8hyyr	3663	12	%	%	NN
cord-006860-a3b8hyyr	3663	13	in	in	IN
cord-006860-a3b8hyyr	3663	14	H20	H20	NNP
cord-006860-a3b8hyyr	3663	15	)	)	-RRB-
cord-006860-a3b8hyyr	3663	16	for	for	IN
cord-006860-a3b8hyyr	3663	17	30	30	CD
cord-006860-a3b8hyyr	3663	18	rain	rain	NN
cord-006860-a3b8hyyr	3663	19	at	at	IN
cord-006860-a3b8hyyr	3663	20	20	20	CD
cord-006860-a3b8hyyr	3663	21	°	°	NN
cord-006860-a3b8hyyr	3663	22	C	c	NN
cord-006860-a3b8hyyr	3663	23	(	(	-LRB-
cord-006860-a3b8hyyr	3663	24	to	to	TO
cord-006860-a3b8hyyr	3663	25	reduce	reduce	VB
cord-006860-a3b8hyyr	3663	26	metallic	metallic	JJ
cord-006860-a3b8hyyr	3663	27	osmium	osmium	NN
cord-006860-a3b8hyyr	3663	28	)	)	-RRB-
cord-006860-a3b8hyyr	3663	29	and	and	CC
cord-006860-a3b8hyyr	3663	30	silver	silver	NN
cord-006860-a3b8hyyr	3663	31	-	-	HYPH
cord-006860-a3b8hyyr	3663	32	enhancement	enhancement	NN
cord-006860-a3b8hyyr	3663	33	using	use	VBG
cord-006860-a3b8hyyr	3663	34	Danscher	Danscher	NNP
cord-006860-a3b8hyyr	3663	35	's	's	POS
cord-006860-a3b8hyyr	3663	36	(	(	-LRB-
cord-006860-a3b8hyyr	3663	37	1981	1981	CD
cord-006860-a3b8hyyr	3663	38	)	)	-RRB-
cord-006860-a3b8hyyr	3663	39	method	method	NN
cord-006860-a3b8hyyr	3663	40	(	(	-LRB-
cord-006860-a3b8hyyr	3663	41	to	to	TO
cord-006860-a3b8hyyr	3663	42	visualize	visualize	VB
cord-006860-a3b8hyyr	3663	43	the	the	DT
cord-006860-a3b8hyyr	3663	44	Fg	Fg	NNP
cord-006860-a3b8hyyr	3663	45	-	-	HYPH
cord-006860-a3b8hyyr	3663	46	Au	Au	NNP
cord-006860-a3b8hyyr	3663	47	)	)	-RRB-
cord-006860-a3b8hyyr	3663	48	.	.	.
cord-006860-a3b8hyyr	3664	1	Examination	examination	NN
cord-006860-a3b8hyyr	3664	2	of	of	IN
cord-006860-a3b8hyyr	3664	3	ADP	ADP	NNP
cord-006860-a3b8hyyr	3664	4	stimulated	stimulate	VBD
cord-006860-a3b8hyyr	3664	5	platelets	platelet	NNS
cord-006860-a3b8hyyr	3664	6	in	in	IN
cord-006860-a3b8hyyr	3664	7	the	the	DT
cord-006860-a3b8hyyr	3664	8	presence	presence	NN
cord-006860-a3b8hyyr	3664	9	of	of	IN
cord-006860-a3b8hyyr	3664	10	40Fg/	40fg/	CD
cord-006860-a3b8hyyr	3665	1	ml	ml	NNP
cord-006860-a3b8hyyr	3665	2	Fg	Fg	NNP
cord-006860-a3b8hyyr	3665	3	-	-	HYPH
cord-006860-a3b8hyyr	3665	4	Au	Au	NNP
cord-006860-a3b8hyyr	3665	5	shows	show	VBZ
cord-006860-a3b8hyyr	3665	6	that	that	IN
cord-006860-a3b8hyyr	3665	7	the	the	DT
cord-006860-a3b8hyyr	3665	8	ligand	ligand	NN
cord-006860-a3b8hyyr	3665	9	is	be	VBZ
cord-006860-a3b8hyyr	3665	10	able	able	JJ
cord-006860-a3b8hyyr	3665	11	to	to	TO
cord-006860-a3b8hyyr	3665	12	mediate	mediate	VB
cord-006860-a3b8hyyr	3665	13	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3665	14	.	.	.
cord-006860-a3b8hyyr	3666	1	The	the	DT
cord-006860-a3b8hyyr	3666	2	examination	examination	NN
cord-006860-a3b8hyyr	3666	3	reveals	reveal	VBZ
cord-006860-a3b8hyyr	3666	4	,	,	,
cord-006860-a3b8hyyr	3666	5	that	that	IN
cord-006860-a3b8hyyr	3666	6	Fg	Fg	NNP
cord-006860-a3b8hyyr	3666	7	-	-	HYPH
cord-006860-a3b8hyyr	3666	8	Au	Au	NNP
cord-006860-a3b8hyyr	3666	9	was	be	VBD
cord-006860-a3b8hyyr	3666	10	present	present	JJ
cord-006860-a3b8hyyr	3666	11	in	in	IN
cord-006860-a3b8hyyr	3666	12	a	a	DT
cord-006860-a3b8hyyr	3666	13	low	low	JJ
cord-006860-a3b8hyyr	3666	14	density	density	NN
cord-006860-a3b8hyyr	3666	15	on	on	IN
cord-006860-a3b8hyyr	3666	16	the	the	DT
cord-006860-a3b8hyyr	3666	17	platelet	platelet	NN
cord-006860-a3b8hyyr	3666	18	surface	surface	NN
cord-006860-a3b8hyyr	3666	19	,	,	,
cord-006860-a3b8hyyr	3666	20	in	in	IN
cord-006860-a3b8hyyr	3666	21	higher	high	JJR
cord-006860-a3b8hyyr	3666	22	density	density	NN
cord-006860-a3b8hyyr	3666	23	in	in	IN
cord-006860-a3b8hyyr	3666	24	the	the	DT
cord-006860-a3b8hyyr	3666	25	surface	surface	NN
cord-006860-a3b8hyyr	3666	26	connected	connect	VBN
cord-006860-a3b8hyyr	3666	27	system	system	NN
cord-006860-a3b8hyyr	3666	28	(	(	-LRB-
cord-006860-a3b8hyyr	3666	29	SCS	SCS	NNP
cord-006860-a3b8hyyr	3666	30	)	)	-RRB-
cord-006860-a3b8hyyr	3666	31	,	,	,
cord-006860-a3b8hyyr	3666	32	in	in	IN
cord-006860-a3b8hyyr	3666	33	coated	coated	JJ
cord-006860-a3b8hyyr	3666	34	pits	pit	NNS
cord-006860-a3b8hyyr	3666	35	and	and	CC
cord-006860-a3b8hyyr	3666	36	vesicles	vesicle	NNS
cord-006860-a3b8hyyr	3666	37	and	and	CC
cord-006860-a3b8hyyr	3666	38	separated	separate	VBD
cord-006860-a3b8hyyr	3666	39	smooth	smooth	JJ
cord-006860-a3b8hyyr	3666	40	vesicles	vesicle	NNS
cord-006860-a3b8hyyr	3666	41	(	(	-LRB-
cord-006860-a3b8hyyr	3666	42	representing	represent	VBG
cord-006860-a3b8hyyr	3666	43	endosomes	endosome	NNS
cord-006860-a3b8hyyr	3666	44	?	?	.
cord-006860-a3b8hyyr	3666	45	)	)	-RRB-
cord-006860-a3b8hyyr	3667	1	as	as	RB
cord-006860-a3b8hyyr	3667	2	well	well	RB
cord-006860-a3b8hyyr	3667	3	as	as	IN
cord-006860-a3b8hyyr	3667	4	in	in	IN
cord-006860-a3b8hyyr	3667	5	the	the	DT
cord-006860-a3b8hyyr	3667	6	matrix	matrix	NN
cord-006860-a3b8hyyr	3667	7	of	of	IN
cord-006860-a3b8hyyr	3667	8	alpha	alpha	NN
cord-006860-a3b8hyyr	3667	9	-	-	HYPH
cord-006860-a3b8hyyr	3667	10	granules	granule	NNS
cord-006860-a3b8hyyr	3667	11	.	.	.
cord-006860-a3b8hyyr	3668	1	After	after	IN
cord-006860-a3b8hyyr	3668	2	30rain	30rain	CD
cord-006860-a3b8hyyr	3668	3	,	,	,
cord-006860-a3b8hyyr	3668	4	the	the	DT
cord-006860-a3b8hyyr	3668	5	number	number	NN
cord-006860-a3b8hyyr	3668	6	of	of	IN
cord-006860-a3b8hyyr	3668	7	labeled	label	VBN
cord-006860-a3b8hyyr	3668	8	granules	granule	NNS
cord-006860-a3b8hyyr	3668	9	was	be	VBD
cord-006860-a3b8hyyr	3668	10	increasing	increase	VBG
cord-006860-a3b8hyyr	3668	11	.	.	.
cord-006860-a3b8hyyr	3669	1	Labels	label	NNS
cord-006860-a3b8hyyr	3669	2	on	on	IN
cord-006860-a3b8hyyr	3669	3	the	the	DT
cord-006860-a3b8hyyr	3669	4	surface	surface	NN
cord-006860-a3b8hyyr	3669	5	and	and	CC
cord-006860-a3b8hyyr	3669	6	on	on	IN
cord-006860-a3b8hyyr	3669	7	the	the	DT
cord-006860-a3b8hyyr	3669	8	mentioned	mention	VBN
cord-006860-a3b8hyyr	3669	9	cytoplasmic	cytoplasmic	JJ
cord-006860-a3b8hyyr	3669	10	membranes	membrane	NNS
cord-006860-a3b8hyyr	3669	11	were	be	VBD
cord-006860-a3b8hyyr	3669	12	observed	observe	VBN
cord-006860-a3b8hyyr	3669	13	during	during	IN
cord-006860-a3b8hyyr	3669	14	the	the	DT
cord-006860-a3b8hyyr	3669	15	whole	whole	JJ
cord-006860-a3b8hyyr	3669	16	period	period	NN
cord-006860-a3b8hyyr	3669	17	of	of	IN
cord-006860-a3b8hyyr	3669	18	incubation	incubation	NN
cord-006860-a3b8hyyr	3669	19	.	.	.
cord-006860-a3b8hyyr	3670	1	HW	HW	NNP
cord-006860-a3b8hyyr	3670	2	or	or	CC
cord-006860-a3b8hyyr	3670	3	Iloprost	Iloprost	NNP
cord-006860-a3b8hyyr	3670	4	did	do	VBD
cord-006860-a3b8hyyr	3670	5	not	not	RB
cord-006860-a3b8hyyr	3670	6	alter	alter	VB
cord-006860-a3b8hyyr	3670	7	the	the	DT
cord-006860-a3b8hyyr	3670	8	resting	rest	VBG
cord-006860-a3b8hyyr	3670	9	GFP	GFP	NNP
cord-006860-a3b8hyyr	3670	10	and	and	CC
cord-006860-a3b8hyyr	3670	11	the	the	DT
cord-006860-a3b8hyyr	3670	12	mentioned	mention	VBN
cord-006860-a3b8hyyr	3670	13	qualitative	qualitative	JJ
cord-006860-a3b8hyyr	3670	14	ultrastructural	ultrastructural	JJ
cord-006860-a3b8hyyr	3670	15	findings	finding	NNS
cord-006860-a3b8hyyr	3670	16	in	in	IN
cord-006860-a3b8hyyr	3670	17	both	both	DT
cord-006860-a3b8hyyr	3670	18	preparations	preparation	NNS
cord-006860-a3b8hyyr	3670	19	did	do	VBD
cord-006860-a3b8hyyr	3670	20	not	not	RB
cord-006860-a3b8hyyr	3670	21	show	show	VB
cord-006860-a3b8hyyr	3670	22	differences	difference	NNS
cord-006860-a3b8hyyr	3670	23	to	to	IN
cord-006860-a3b8hyyr	3670	24	the	the	DT
cord-006860-a3b8hyyr	3670	25	controls	control	NNS
cord-006860-a3b8hyyr	3670	26	.	.	.
cord-006860-a3b8hyyr	3671	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3671	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	3671	3	from	from	IN
cord-006860-a3b8hyyr	3671	4	the	the	DT
cord-006860-a3b8hyyr	3671	5	results	result	NNS
cord-006860-a3b8hyyr	3671	6	with	with	IN
cord-006860-a3b8hyyr	3671	7	HWthat	HWthat	NNP
cord-006860-a3b8hyyr	3671	8	the	the	DT
cord-006860-a3b8hyyr	3671	9	regular	regular	JJ
cord-006860-a3b8hyyr	3671	10	contractile	contractile	JJ
cord-006860-a3b8hyyr	3671	11	function	function	NN
cord-006860-a3b8hyyr	3671	12	of	of	IN
cord-006860-a3b8hyyr	3671	13	the	the	DT
cord-006860-a3b8hyyr	3671	14	cytoskeleton	cytoskeleton	NN
cord-006860-a3b8hyyr	3671	15	is	be	VBZ
cord-006860-a3b8hyyr	3671	16	not	not	RB
cord-006860-a3b8hyyr	3671	17	necessary	necessary	JJ
cord-006860-a3b8hyyr	3671	18	to	to	TO
cord-006860-a3b8hyyr	3671	19	transport	transport	VB
cord-006860-a3b8hyyr	3671	20	the	the	DT
cord-006860-a3b8hyyr	3671	21	Fg	Fg	NNP
cord-006860-a3b8hyyr	3671	22	-	-	HYPH
cord-006860-a3b8hyyr	3671	23	Au	Au	NNP
cord-006860-a3b8hyyr	3671	24	in	in	IN
cord-006860-a3b8hyyr	3671	25	resting	rest	VBG
cord-006860-a3b8hyyr	3671	26	platelets	platelet	NNS
cord-006860-a3b8hyyr	3671	27	.	.	.
cord-006860-a3b8hyyr	3672	1	METHODS	methods	NN
cord-006860-a3b8hyyr	3672	2	:	:	:
cord-006860-a3b8hyyr	3673	1	EDTA	EDTA	NNP
cord-006860-a3b8hyyr	3673	2	anticoagulated	anticoagulate	VBD
cord-006860-a3b8hyyr	3673	3	whole	whole	JJ
cord-006860-a3b8hyyr	3673	4	blood	blood	NN
cord-006860-a3b8hyyr	3673	5	was	be	VBD
cord-006860-a3b8hyyr	3673	6	incubated	incubate	VBN
cord-006860-a3b8hyyr	3673	7	with	with	IN
cord-006860-a3b8hyyr	3673	8	thiazole	thiazole	NNP
cord-006860-a3b8hyyr	3673	9	orange	orange	NNP
cord-006860-a3b8hyyr	3673	10	and	and	CC
cord-006860-a3b8hyyr	3673	11	analyzed	analyze	VBD
cord-006860-a3b8hyyr	3673	12	with	with	IN
cord-006860-a3b8hyyr	3673	13	a	a	DT
cord-006860-a3b8hyyr	3673	14	flow	flow	NN
cord-006860-a3b8hyyr	3673	15	cytometer	cytometer	NN
cord-006860-a3b8hyyr	3673	16	.	.	.
cord-006860-a3b8hyyr	3674	1	Young	young	JJ
cord-006860-a3b8hyyr	3674	2	platelets	platelet	NNS
cord-006860-a3b8hyyr	3674	3	were	be	VBD
cord-006860-a3b8hyyr	3674	4	defined	define	VBN
cord-006860-a3b8hyyr	3674	5	by	by	IN
cord-006860-a3b8hyyr	3674	6	having	have	VBG
cord-006860-a3b8hyyr	3674	7	a	a	DT
cord-006860-a3b8hyyr	3674	8	high	high	JJ
cord-006860-a3b8hyyr	3674	9	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	3674	10	from	from	IN
cord-006860-a3b8hyyr	3674	11	thiazole	thiazole	NNP
cord-006860-a3b8hyyr	3674	12	orange	orange	NNP
cord-006860-a3b8hyyr	3674	13	(	(	-LRB-
cord-006860-a3b8hyyr	3674	14	normalized	normalize	VBN
cord-006860-a3b8hyyr	3674	15	to	to	IN
cord-006860-a3b8hyyr	3674	16	platelet	platelet	NN
cord-006860-a3b8hyyr	3674	17	size	size	NN
cord-006860-a3b8hyyr	3674	18	)	)	-RRB-
cord-006860-a3b8hyyr	3674	19	.	.	.
cord-006860-a3b8hyyr	3675	1	Platelets	platelet	NNS
cord-006860-a3b8hyyr	3675	2	were	be	VBD
cord-006860-a3b8hyyr	3675	3	also	also	RB
cord-006860-a3b8hyyr	3675	4	incubated	incubate	VBN
cord-006860-a3b8hyyr	3675	5	with	with	IN
cord-006860-a3b8hyyr	3675	6	fluorescent	fluorescent	JJ
cord-006860-a3b8hyyr	3675	7	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3675	8	to	to	IN
cord-006860-a3b8hyyr	3675	9	GPIb	GPIb	NNS
cord-006860-a3b8hyyr	3675	10	,	,	,
cord-006860-a3b8hyyr	3675	11	GP	GP	NNP
cord-006860-a3b8hyyr	3675	12	lib	lib	NN
cord-006860-a3b8hyyr	3675	13	/	/	SYM
cord-006860-a3b8hyyr	3675	14	Ilia	Ilia	NNP
cord-006860-a3b8hyyr	3675	15	and	and	CC
cord-006860-a3b8hyyr	3675	16	GMP-140	GMP-140	NNP
cord-006860-a3b8hyyr	3675	17	(	(	-LRB-
cord-006860-a3b8hyyr	3675	18	two	two	CD
cord-006860-a3b8hyyr	3675	19	colour	colour	NN
cord-006860-a3b8hyyr	3675	20	method	method	NN
cord-006860-a3b8hyyr	3675	21	)	)	-RRB-
cord-006860-a3b8hyyr	3675	22	.	.	.
cord-006860-a3b8hyyr	3676	1	RESULTS	result	NNS
cord-006860-a3b8hyyr	3676	2	:	:	:
cord-006860-a3b8hyyr	3677	1	Surface	surface	NN
cord-006860-a3b8hyyr	3677	2	expression	expression	NN
cord-006860-a3b8hyyr	3677	3	of	of	IN
cord-006860-a3b8hyyr	3677	4	GPIb	GPIb	NNS
cord-006860-a3b8hyyr	3677	5	was	be	VBD
cord-006860-a3b8hyyr	3677	6	the	the	DT
cord-006860-a3b8hyyr	3677	7	same	same	JJ
cord-006860-a3b8hyyr	3677	8	in	in	IN
cord-006860-a3b8hyyr	3677	9	young	young	JJ
cord-006860-a3b8hyyr	3677	10	and	and	CC
cord-006860-a3b8hyyr	3677	11	older	old	JJR
cord-006860-a3b8hyyr	3677	12	platelets	platelet	NNS
cord-006860-a3b8hyyr	3677	13	.	.	.
cord-006860-a3b8hyyr	3678	1	Results	result	NNS
cord-006860-a3b8hyyr	3678	2	for	for	IN
cord-006860-a3b8hyyr	3678	3	GP	GP	NNP
cord-006860-a3b8hyyr	3678	4	lib	lib	NN
cord-006860-a3b8hyyr	3678	5	/	/	SYM
cord-006860-a3b8hyyr	3678	6	Ilia	Ilia	NNP
cord-006860-a3b8hyyr	3678	7	and	and	CC
cord-006860-a3b8hyyr	3678	8	GMP-140	GMP-140	NNP
cord-006860-a3b8hyyr	3678	9	(	(	-LRB-
cord-006860-a3b8hyyr	3678	10	in	in	IN
cord-006860-a3b8hyyr	3678	11	resting	rest	VBG
cord-006860-a3b8hyyr	3678	12	and	and	CC
cord-006860-a3b8hyyr	3678	13	activated	activate	VBN
cord-006860-a3b8hyyr	3678	14	platelets	platelet	NNS
cord-006860-a3b8hyyr	3678	15	)	)	-RRB-
cord-006860-a3b8hyyr	3678	16	will	will	MD
cord-006860-a3b8hyyr	3678	17	be	be	VB
cord-006860-a3b8hyyr	3678	18	presented	present	VBN
cord-006860-a3b8hyyr	3678	19	.	.	.
cord-006860-a3b8hyyr	3679	1	CONCLUSION	conclusion	NN
cord-006860-a3b8hyyr	3679	2	:	:	:
cord-006860-a3b8hyyr	3680	1	Young	young	JJ
cord-006860-a3b8hyyr	3680	2	platelets	platelet	NNS
cord-006860-a3b8hyyr	3680	3	can	can	MD
cord-006860-a3b8hyyr	3680	4	easily	easily	RB
cord-006860-a3b8hyyr	3680	5	be	be	VB
cord-006860-a3b8hyyr	3680	6	detected	detect	VBN
cord-006860-a3b8hyyr	3680	7	using	use	VBG
cord-006860-a3b8hyyr	3680	8	thiazole	thiazole	NNP
cord-006860-a3b8hyyr	3680	9	orange	orange	NNP
cord-006860-a3b8hyyr	3680	10	and	and	CC
cord-006860-a3b8hyyr	3680	11	flow	flow	NN
cord-006860-a3b8hyyr	3680	12	cytometry	cytometry	NN
cord-006860-a3b8hyyr	3680	13	.	.	.
cord-006860-a3b8hyyr	3681	1	There	there	EX
cord-006860-a3b8hyyr	3681	2	is	be	VBZ
cord-006860-a3b8hyyr	3681	3	no	no	DT
cord-006860-a3b8hyyr	3681	4	differential	differential	JJ
cord-006860-a3b8hyyr	3681	5	expression	expression	NN
cord-006860-a3b8hyyr	3681	6	for	for	IN
cord-006860-a3b8hyyr	3681	7	GPIb	GPIb	NNS
cord-006860-a3b8hyyr	3681	8	.	.	.
cord-006860-a3b8hyyr	3682	1	Further	further	JJ
cord-006860-a3b8hyyr	3682	2	results	result	NNS
cord-006860-a3b8hyyr	3682	3	will	will	MD
cord-006860-a3b8hyyr	3682	4	be	be	VB
cord-006860-a3b8hyyr	3682	5	presented	present	VBN
cord-006860-a3b8hyyr	3682	6	.	.	.
cord-006860-a3b8hyyr	3683	1	The	the	DT
cord-006860-a3b8hyyr	3683	2	influence	influence	NN
cord-006860-a3b8hyyr	3683	3	of	of	IN
cord-006860-a3b8hyyr	3683	4	erythrocyte	erythrocyte	NN
cord-006860-a3b8hyyr	3683	5	and	and	CC
cord-006860-a3b8hyyr	3683	6	thrombocyte	thrombocyte	NN
cord-006860-a3b8hyyr	3683	7	content	content	NN
cord-006860-a3b8hyyr	3683	8	on	on	IN
cord-006860-a3b8hyyr	3683	9	the	the	DT
cord-006860-a3b8hyyr	3683	10	release	release	NN
cord-006860-a3b8hyyr	3683	11	of	of	IN
cord-006860-a3b8hyyr	3683	12	ATP	ATP	NNP
cord-006860-a3b8hyyr	3683	13	by	by	IN
cord-006860-a3b8hyyr	3683	14	different	different	JJ
cord-006860-a3b8hyyr	3683	15	agents	agent	NNS
cord-006860-a3b8hyyr	3683	16	in	in	IN
cord-006860-a3b8hyyr	3683	17	whole	whole	JJ
cord-006860-a3b8hyyr	3683	18	blood	blood	NN
cord-006860-a3b8hyyr	3683	19	specimens	specimen	NNS
cord-006860-a3b8hyyr	3683	20	was	be	VBD
cord-006860-a3b8hyyr	3683	21	tested	test	VBN
cord-006860-a3b8hyyr	3683	22	.	.	.
cord-006860-a3b8hyyr	3684	1	The	the	DT
cord-006860-a3b8hyyr	3684	2	measurement	measurement	NN
cord-006860-a3b8hyyr	3684	3	had	have	VBD
cord-006860-a3b8hyyr	3684	4	been	be	VBN
cord-006860-a3b8hyyr	3684	5	performed	perform	VBN
cord-006860-a3b8hyyr	3684	6	in	in	IN
cord-006860-a3b8hyyr	3684	7	the	the	DT
cord-006860-a3b8hyyr	3684	8	Lumi	Lumi	NNP
cord-006860-a3b8hyyr	3684	9	-	-	HYPH
cord-006860-a3b8hyyr	3684	10	Aggregometer	Aggregometer	NNP
cord-006860-a3b8hyyr	3684	11	using	use	VBG
cord-006860-a3b8hyyr	3684	12	the	the	DT
cord-006860-a3b8hyyr	3684	13	principle	principle	NN
cord-006860-a3b8hyyr	3684	14	of	of	IN
cord-006860-a3b8hyyr	3684	15	the	the	DT
cord-006860-a3b8hyyr	3684	16	luciferin	luciferin	NN
cord-006860-a3b8hyyr	3684	17	-	-	HYPH
cord-006860-a3b8hyyr	3684	18	luciferase	luciferase	NN
cord-006860-a3b8hyyr	3684	19	reaction	reaction	NN
cord-006860-a3b8hyyr	3684	20	.	.	.
cord-006860-a3b8hyyr	3685	1	Altogether	altogether	RB
cord-006860-a3b8hyyr	3685	2	39	39	CD
cord-006860-a3b8hyyr	3685	3	blood	blood	NN
cord-006860-a3b8hyyr	3685	4	samples	sample	NNS
cord-006860-a3b8hyyr	3685	5	were	be	VBD
cord-006860-a3b8hyyr	3685	6	diluted	dilute	VBN
cord-006860-a3b8hyyr	3685	7	gradually	gradually	RB
cord-006860-a3b8hyyr	3685	8	before	before	IN
cord-006860-a3b8hyyr	3685	9	induction	induction	NN
cord-006860-a3b8hyyr	3685	10	of	of	IN
cord-006860-a3b8hyyr	3685	11	the	the	DT
cord-006860-a3b8hyyr	3685	12	release	release	NN
cord-006860-a3b8hyyr	3685	13	reaction	reaction	NN
cord-006860-a3b8hyyr	3685	14	by	by	IN
cord-006860-a3b8hyyr	3685	15	arachidonic	arachidonic	JJ
cord-006860-a3b8hyyr	3685	16	acid	acid	NN
cord-006860-a3b8hyyr	3685	17	(	(	-LRB-
cord-006860-a3b8hyyr	3685	18	1,25	1,25	CD
cord-006860-a3b8hyyr	3685	19	mmol	mmol	JJ
cord-006860-a3b8hyyr	3685	20	/	/	SYM
cord-006860-a3b8hyyr	3685	21	I	-PRON-	PRP
cord-006860-a3b8hyyr	3685	22	final	final	JJ
cord-006860-a3b8hyyr	3685	23	concentration	concentration	NN
cord-006860-a3b8hyyr	3685	24	)	)	-RRB-
cord-006860-a3b8hyyr	3685	25	,	,	,
cord-006860-a3b8hyyr	3685	26	ADP	ADP	NNP
cord-006860-a3b8hyyr	3685	27	(	(	-LRB-
cord-006860-a3b8hyyr	3685	28	30	30	CD
cord-006860-a3b8hyyr	3685	29	IJmol	IJmol	NNP
cord-006860-a3b8hyyr	3685	30	/	/	SYM
cord-006860-a3b8hyyr	3685	31	I	i	NN
cord-006860-a3b8hyyr	3685	32	)	)	-RRB-
cord-006860-a3b8hyyr	3685	33	and	and	CC
cord-006860-a3b8hyyr	3685	34	collagen	collagen	NNP
cord-006860-a3b8hyyr	3685	35	(	(	-LRB-
cord-006860-a3b8hyyr	3685	36	1,0	1,0	CD
cord-006860-a3b8hyyr	3685	37	and	and	CC
cord-006860-a3b8hyyr	3685	38	5,0	5,0	CD
cord-006860-a3b8hyyr	3685	39	tJg	tJg	NNS
cord-006860-a3b8hyyr	3685	40	/	/	SYM
cord-006860-a3b8hyyr	3685	41	ml	ml	NN
cord-006860-a3b8hyyr	3685	42	)	)	-RRB-
cord-006860-a3b8hyyr	3685	43	.	.	.
cord-006860-a3b8hyyr	3686	1	The	the	DT
cord-006860-a3b8hyyr	3686	2	peak	peak	NN
cord-006860-a3b8hyyr	3686	3	of	of	IN
cord-006860-a3b8hyyr	3686	4	the	the	DT
cord-006860-a3b8hyyr	3686	5	obtained	obtain	VBN
cord-006860-a3b8hyyr	3686	6	curves	curve	NNS
cord-006860-a3b8hyyr	3686	7	was	be	VBD
cord-006860-a3b8hyyr	3686	8	transformed	transform	VBN
cord-006860-a3b8hyyr	3686	9	into	into	IN
cord-006860-a3b8hyyr	3686	10	percent	percent	NN
cord-006860-a3b8hyyr	3686	11	values	value	NNS
cord-006860-a3b8hyyr	3686	12	of	of	IN
cord-006860-a3b8hyyr	3686	13	the	the	DT
cord-006860-a3b8hyyr	3686	14	maximal	maximal	JJ
cord-006860-a3b8hyyr	3686	15	deflection	deflection	NN
cord-006860-a3b8hyyr	3686	16	by	by	IN
cord-006860-a3b8hyyr	3686	17	the	the	DT
cord-006860-a3b8hyyr	3686	18	undiluted	undiluted	JJ
cord-006860-a3b8hyyr	3686	19	sample	sample	NN
cord-006860-a3b8hyyr	3686	20	(=	(=	-LRB-
cord-006860-a3b8hyyr	3686	21	peak	peak	NN
cord-006860-a3b8hyyr	3686	22	in	in	IN
cord-006860-a3b8hyyr	3686	23	relation	relation	NN
cord-006860-a3b8hyyr	3686	24	)	)	-RRB-
cord-006860-a3b8hyyr	3686	25	and	and	CC
cord-006860-a3b8hyyr	3686	26	into	into	IN
cord-006860-a3b8hyyr	3686	27	ATP	ATP	NNP
cord-006860-a3b8hyyr	3686	28	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3686	29	(=	(=	NNP
cord-006860-a3b8hyyr	3686	30	absolute	absolute	JJ
cord-006860-a3b8hyyr	3686	31	peak	peak	NN
cord-006860-a3b8hyyr	3686	32	)	)	-RRB-
cord-006860-a3b8hyyr	3686	33	after	after	IN
cord-006860-a3b8hyyr	3686	34	testing	test	VBG
cord-006860-a3b8hyyr	3686	35	the	the	DT
cord-006860-a3b8hyyr	3686	36	ATP	ATP	NNP
cord-006860-a3b8hyyr	3686	37	standard	standard	NN
cord-006860-a3b8hyyr	3686	38	in	in	IN
cord-006860-a3b8hyyr	3686	39	parallel	parallel	NN
cord-006860-a3b8hyyr	3686	40	for	for	IN
cord-006860-a3b8hyyr	3686	41	each	each	DT
cord-006860-a3b8hyyr	3686	42	dilution	dilution	NN
cord-006860-a3b8hyyr	3686	43	step	step	NN
cord-006860-a3b8hyyr	3686	44	separately	separately	RB
cord-006860-a3b8hyyr	3686	45	.	.	.
cord-006860-a3b8hyyr	3687	1	The	the	DT
cord-006860-a3b8hyyr	3687	2	peak	peak	NN
cord-006860-a3b8hyyr	3687	3	in	in	IN
cord-006860-a3b8hyyr	3687	4	relation	relation	NN
cord-006860-a3b8hyyr	3687	5	increases	increase	NNS
cord-006860-a3b8hyyr	3687	6	by	by	IN
cord-006860-a3b8hyyr	3687	7	increasing	increase	VBG
cord-006860-a3b8hyyr	3687	8	dilution	dilution	NN
cord-006860-a3b8hyyr	3687	9	with	with	IN
cord-006860-a3b8hyyr	3687	10	all	all	DT
cord-006860-a3b8hyyr	3687	11	inducers	inducer	NNS
cord-006860-a3b8hyyr	3687	12	.	.	.
cord-006860-a3b8hyyr	3688	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	3688	2	was	be	VBD
cord-006860-a3b8hyyr	3688	3	identic	identic	JJ
cord-006860-a3b8hyyr	3688	4	with	with	IN
cord-006860-a3b8hyyr	3688	5	the	the	DT
cord-006860-a3b8hyyr	3688	6	ATP	ATP	NNP
cord-006860-a3b8hyyr	3688	7	standard	standard	NN
cord-006860-a3b8hyyr	3688	8	and	and	CC
cord-006860-a3b8hyyr	3688	9	with	with	IN
cord-006860-a3b8hyyr	3688	10	collagen	collagen	NN
cord-006860-a3b8hyyr	3688	11	,	,	,
cord-006860-a3b8hyyr	3688	12	somewhat	somewhat	RB
cord-006860-a3b8hyyr	3688	13	lower	lower	RBR
cord-006860-a3b8hyyr	3688	14	with	with	IN
cord-006860-a3b8hyyr	3688	15	arachidonic	arachidonic	JJ
cord-006860-a3b8hyyr	3688	16	acid	acid	NN
cord-006860-a3b8hyyr	3688	17	and	and	CC
cord-006860-a3b8hyyr	3688	18	much	much	RB
cord-006860-a3b8hyyr	3688	19	higher	high	JJR
cord-006860-a3b8hyyr	3688	20	by	by	IN
cord-006860-a3b8hyyr	3688	21	ADP	ADP	NNP
cord-006860-a3b8hyyr	3688	22	.	.	.
cord-006860-a3b8hyyr	3689	1	A	a	DT
cord-006860-a3b8hyyr	3689	2	luminescence	luminescence	NN
cord-006860-a3b8hyyr	3689	3	-	-	HYPH
cord-006860-a3b8hyyr	3689	4	optical	optical	JJ
cord-006860-a3b8hyyr	3689	5	effect	effect	NN
cord-006860-a3b8hyyr	3689	6	may	may	MD
cord-006860-a3b8hyyr	3689	7	influence	influence	VB
cord-006860-a3b8hyyr	3689	8	all	all	PDT
cord-006860-a3b8hyyr	3689	9	these	these	DT
cord-006860-a3b8hyyr	3689	10	results	result	NNS
cord-006860-a3b8hyyr	3689	11	.	.	.
cord-006860-a3b8hyyr	3690	1	The	the	DT
cord-006860-a3b8hyyr	3690	2	absolute	absolute	JJ
cord-006860-a3b8hyyr	3690	3	peak	peak	NN
cord-006860-a3b8hyyr	3690	4	decreases	decrease	NNS
cord-006860-a3b8hyyr	3690	5	by	by	IN
cord-006860-a3b8hyyr	3690	6	dilution	dilution	NN
cord-006860-a3b8hyyr	3690	7	under	under	IN
cord-006860-a3b8hyyr	3690	8	arachidonic	arachidonic	JJ
cord-006860-a3b8hyyr	3690	9	acid	acid	NN
cord-006860-a3b8hyyr	3690	10	and	and	CC
cord-006860-a3b8hyyr	3690	11	collagen	collagen	NN
cord-006860-a3b8hyyr	3690	12	as	as	IN
cord-006860-a3b8hyyr	3690	13	it	-PRON-	PRP
cord-006860-a3b8hyyr	3690	14	was	be	VBD
cord-006860-a3b8hyyr	3690	15	expected	expect	VBN
cord-006860-a3b8hyyr	3690	16	by	by	IN
cord-006860-a3b8hyyr	3690	17	the	the	DT
cord-006860-a3b8hyyr	3690	18	decreasing	decrease	VBG
cord-006860-a3b8hyyr	3690	19	thrombocyte	thrombocyte	NN
cord-006860-a3b8hyyr	3690	20	content	content	NN
cord-006860-a3b8hyyr	3690	21	of	of	IN
cord-006860-a3b8hyyr	3690	22	the	the	DT
cord-006860-a3b8hyyr	3690	23	samples	sample	NNS
cord-006860-a3b8hyyr	3690	24	.	.	.
cord-006860-a3b8hyyr	3691	1	Under	under	IN
cord-006860-a3b8hyyr	3691	2	induction	induction	NN
cord-006860-a3b8hyyr	3691	3	by	by	IN
cord-006860-a3b8hyyr	3691	4	ADP	ADP	NNP
cord-006860-a3b8hyyr	3691	5	no	no	DT
cord-006860-a3b8hyyr	3691	6	decrease	decrease	NN
cord-006860-a3b8hyyr	3691	7	of	of	IN
cord-006860-a3b8hyyr	3691	8	the	the	DT
cord-006860-a3b8hyyr	3691	9	absolute	absolute	JJ
cord-006860-a3b8hyyr	3691	10	peaks	peak	NNS
cord-006860-a3b8hyyr	3691	11	by	by	IN
cord-006860-a3b8hyyr	3691	12	increasing	increase	VBG
cord-006860-a3b8hyyr	3691	13	dilution	dilution	NN
cord-006860-a3b8hyyr	3691	14	of	of	IN
cord-006860-a3b8hyyr	3691	15	the	the	DT
cord-006860-a3b8hyyr	3691	16	samples	sample	NNS
cord-006860-a3b8hyyr	3691	17	was	be	VBD
cord-006860-a3b8hyyr	3691	18	abserved	abserve	VBN
cord-006860-a3b8hyyr	3691	19	.	.	.
cord-006860-a3b8hyyr	3692	1	This	this	DT
cord-006860-a3b8hyyr	3692	2	can	can	MD
cord-006860-a3b8hyyr	3692	3	be	be	VB
cord-006860-a3b8hyyr	3692	4	explained	explain	VBN
cord-006860-a3b8hyyr	3692	5	only	only	RB
cord-006860-a3b8hyyr	3692	6	by	by	IN
cord-006860-a3b8hyyr	3692	7	liberation	liberation	NN
cord-006860-a3b8hyyr	3692	8	of	of	IN
cord-006860-a3b8hyyr	3692	9	ATP	ATP	NNP
cord-006860-a3b8hyyr	3692	10	from	from	IN
cord-006860-a3b8hyyr	3692	11	the	the	DT
cord-006860-a3b8hyyr	3692	12	erythrocytes	erythrocyte	NNS
cord-006860-a3b8hyyr	3692	13	.	.	.
cord-006860-a3b8hyyr	3693	1	The	the	DT
cord-006860-a3b8hyyr	3693	2	ATP	ATP	NNP
cord-006860-a3b8hyyr	3693	3	standard	standard	NN
cord-006860-a3b8hyyr	3693	4	is	be	VBZ
cord-006860-a3b8hyyr	3693	5	essential	essential	JJ
cord-006860-a3b8hyyr	3693	6	for	for	IN
cord-006860-a3b8hyyr	3693	7	the	the	DT
cord-006860-a3b8hyyr	3693	8	quantification	quantification	NN
cord-006860-a3b8hyyr	3693	9	of	of	IN
cord-006860-a3b8hyyr	3693	10	the	the	DT
cord-006860-a3b8hyyr	3693	11	release	release	NN
cord-006860-a3b8hyyr	3693	12	reaction	reaction	NN
cord-006860-a3b8hyyr	3693	13	.	.	.
cord-006860-a3b8hyyr	3694	1	ADP	ADP	NNP
cord-006860-a3b8hyyr	3694	2	does	do	VBZ
cord-006860-a3b8hyyr	3694	3	n't	not	RB
cord-006860-a3b8hyyr	3694	4	suit	suit	VB
cord-006860-a3b8hyyr	3694	5	for	for	IN
cord-006860-a3b8hyyr	3694	6	it	-PRON-	PRP
cord-006860-a3b8hyyr	3694	7	.	.	.
cord-006860-a3b8hyyr	3695	1	Collagen	collagen	NN
cord-006860-a3b8hyyr	3695	2	with	with	IN
cord-006860-a3b8hyyr	3695	3	a	a	DT
cord-006860-a3b8hyyr	3695	4	final	final	JJ
cord-006860-a3b8hyyr	3695	5	concentration	concentration	NN
cord-006860-a3b8hyyr	3695	6	of	of	IN
cord-006860-a3b8hyyr	3695	7	1	1	CD
cord-006860-a3b8hyyr	3695	8	pg	pg	NNP
cord-006860-a3b8hyyr	3695	9	/	/	SYM
cord-006860-a3b8hyyr	3695	10	ml	ml	NNP
cord-006860-a3b8hyyr	3695	11	was	be	VBD
cord-006860-a3b8hyyr	3695	12	proven	prove	VBN
cord-006860-a3b8hyyr	3695	13	as	as	IN
cord-006860-a3b8hyyr	3695	14	the	the	DT
cord-006860-a3b8hyyr	3695	15	best	good	JJS
cord-006860-a3b8hyyr	3695	16	inducer	inducer	NN
cord-006860-a3b8hyyr	3695	17	.	.	.
cord-006860-a3b8hyyr	3696	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	3696	2	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3696	3	induced	induce	VBN
cord-006860-a3b8hyyr	3696	4	by	by	IN
cord-006860-a3b8hyyr	3696	5	several	several	JJ
cord-006860-a3b8hyyr	3696	6	agents	agent	NNS
cord-006860-a3b8hyyr	3696	7	has	have	VBZ
cord-006860-a3b8hyyr	3696	8	been	be	VBN
cord-006860-a3b8hyyr	3696	9	photometrically	photometrically	RB
cord-006860-a3b8hyyr	3696	10	investigated	investigate	VBN
cord-006860-a3b8hyyr	3696	11	in	in	IN
cord-006860-a3b8hyyr	3696	12	disc	disc	NN
cord-006860-a3b8hyyr	3696	13	shaped	shape	VBN
cord-006860-a3b8hyyr	3696	14	rotating	rotate	VBG
cord-006860-a3b8hyyr	3696	15	cuvettes	cuvette	NNS
cord-006860-a3b8hyyr	3696	16	coated	coat	VBN
cord-006860-a3b8hyyr	3696	17	with	with	IN
cord-006860-a3b8hyyr	3696	18	vessel	vessel	NN
cord-006860-a3b8hyyr	3696	19	wall	wall	NN
cord-006860-a3b8hyyr	3696	20	tissues	tissue	NNS
cord-006860-a3b8hyyr	3696	21	obtained	obtain	VBN
cord-006860-a3b8hyyr	3696	22	from	from	IN
cord-006860-a3b8hyyr	3696	23	human	human	JJ
cord-006860-a3b8hyyr	3696	24	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	3696	25	cord	cord	NN
cord-006860-a3b8hyyr	3696	26	,	,	,
cord-006860-a3b8hyyr	3696	27	either	either	CC
cord-006860-a3b8hyyr	3696	28	endothelium	endothelium	NN
cord-006860-a3b8hyyr	3696	29	or	or	CC
cord-006860-a3b8hyyr	3696	30	smooth	smooth	JJ
cord-006860-a3b8hyyr	3696	31	muscle	muscle	NN
cord-006860-a3b8hyyr	3696	32	cells	cell	NNS
cord-006860-a3b8hyyr	3696	33	or	or	CC
cord-006860-a3b8hyyr	3696	34	extracellular	extracellular	JJ
cord-006860-a3b8hyyr	3696	35	matrix	matrix	NN
cord-006860-a3b8hyyr	3696	36	or	or	CC
cord-006860-a3b8hyyr	3696	37	combinations	combination	NNS
cord-006860-a3b8hyyr	3696	38	of	of	IN
cord-006860-a3b8hyyr	3696	39	them	-PRON-	PRP
cord-006860-a3b8hyyr	3696	40	.	.	.
cord-006860-a3b8hyyr	3697	1	In	in	IN
cord-006860-a3b8hyyr	3697	2	addition	addition	NN
cord-006860-a3b8hyyr	3697	3	,	,	,
cord-006860-a3b8hyyr	3697	4	effects	effect	NNS
cord-006860-a3b8hyyr	3697	5	of	of	IN
cord-006860-a3b8hyyr	3697	6	endothelium	endothelium	NN
cord-006860-a3b8hyyr	3697	7	incubated	incubate	VBN
cord-006860-a3b8hyyr	3697	8	with	with	IN
cord-006860-a3b8hyyr	3697	9	several	several	JJ
cord-006860-a3b8hyyr	3697	10	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	3697	11	on	on	IN
cord-006860-a3b8hyyr	3697	12	platelet	platelet	NN
cord-006860-a3b8hyyr	3697	13	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3697	14	have	have	VBP
cord-006860-a3b8hyyr	3697	15	been	be	VBN
cord-006860-a3b8hyyr	3697	16	studied	study	VBN
cord-006860-a3b8hyyr	3697	17	.	.	.
cord-006860-a3b8hyyr	3698	1	Endothelial	endothelial	JJ
cord-006860-a3b8hyyr	3698	2	cells	cell	NNS
cord-006860-a3b8hyyr	3698	3	strongly	strongly	RB
cord-006860-a3b8hyyr	3698	4	inhibited	inhibit	VBD
cord-006860-a3b8hyyr	3698	5	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3698	6	depending	depend	VBG
cord-006860-a3b8hyyr	3698	7	on	on	IN
cord-006860-a3b8hyyr	3698	8	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3698	9	cell	cell	NN
cord-006860-a3b8hyyr	3698	10	count	count	NN
cord-006860-a3b8hyyr	3698	11	and	and	CC
cord-006860-a3b8hyyr	3698	12	the	the	DT
cord-006860-a3b8hyyr	3698	13	concentration	concentration	NN
cord-006860-a3b8hyyr	3698	14	of	of	IN
cord-006860-a3b8hyyr	3698	15	the	the	DT
cord-006860-a3b8hyyr	3698	16	inducer	inducer	NN
cord-006860-a3b8hyyr	3698	17	.	.	.
cord-006860-a3b8hyyr	3699	1	Smooth	smooth	JJ
cord-006860-a3b8hyyr	3699	2	muscle	muscle	NN
cord-006860-a3b8hyyr	3699	3	cells	cell	NNS
cord-006860-a3b8hyyr	3699	4	showed	show	VBD
cord-006860-a3b8hyyr	3699	5	the	the	DT
cord-006860-a3b8hyyr	3699	6	same	same	JJ
cord-006860-a3b8hyyr	3699	7	effect	effect	NN
cord-006860-a3b8hyyr	3699	8	but	but	CC
cord-006860-a3b8hyyr	3699	9	very	very	RB
cord-006860-a3b8hyyr	3699	10	less	less	RBR
cord-006860-a3b8hyyr	3699	11	marked	marked	JJ
cord-006860-a3b8hyyr	3699	12	.	.	.
cord-006860-a3b8hyyr	3700	1	In	in	IN
cord-006860-a3b8hyyr	3700	2	presence	presence	NN
cord-006860-a3b8hyyr	3700	3	of	of	IN
cord-006860-a3b8hyyr	3700	4	extracellnlar	extracellnlar	NNP
cord-006860-a3b8hyyr	3700	5	matrix	matrix	NNP
cord-006860-a3b8hyyr	3700	6	spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	3700	7	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3700	8	occured	occur	VBD
cord-006860-a3b8hyyr	3700	9	.	.	.
cord-006860-a3b8hyyr	3701	1	Endothelium	endothelium	NN
cord-006860-a3b8hyyr	3701	2	could	could	MD
cord-006860-a3b8hyyr	3701	3	inhibit	inhibit	VB
cord-006860-a3b8hyyr	3701	4	this	this	DT
cord-006860-a3b8hyyr	3701	5	spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	3701	6	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3701	7	when	when	WRB
cord-006860-a3b8hyyr	3701	8	present	present	JJ
cord-006860-a3b8hyyr	3701	9	in	in	IN
cord-006860-a3b8hyyr	3701	10	the	the	DT
cord-006860-a3b8hyyr	3701	11	same	same	JJ
cord-006860-a3b8hyyr	3701	12	cuvette	cuvette	NN
cord-006860-a3b8hyyr	3701	13	,	,	,
cord-006860-a3b8hyyr	3701	14	smooth	smooth	JJ
cord-006860-a3b8hyyr	3701	15	muscle	muscle	NN
cord-006860-a3b8hyyr	3701	16	cell	cell	NN
cord-006860-a3b8hyyr	3701	17	could	could	MD
cord-006860-a3b8hyyr	3701	18	not	not	RB
cord-006860-a3b8hyyr	3701	19	.	.	.
cord-006860-a3b8hyyr	3702	1	Incubation	incubation	NN
cord-006860-a3b8hyyr	3702	2	of	of	IN
cord-006860-a3b8hyyr	3702	3	endothelium	endothelium	NN
cord-006860-a3b8hyyr	3702	4	with	with	IN
cord-006860-a3b8hyyr	3702	5	several	several	JJ
cord-006860-a3b8hyyr	3702	6	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	3702	7	increased	increase	VBD
cord-006860-a3b8hyyr	3702	8	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3702	9	anti	anti	JJ
cord-006860-a3b8hyyr	3702	10	-	-	JJ
cord-006860-a3b8hyyr	3702	11	thombotic	thombotic	JJ
cord-006860-a3b8hyyr	3702	12	properties	property	NNS
cord-006860-a3b8hyyr	3702	13	.	.	.
cord-006860-a3b8hyyr	3703	1	For	for	IN
cord-006860-a3b8hyyr	3703	2	example	example	NN
cord-006860-a3b8hyyr	3703	3	,	,	,
cord-006860-a3b8hyyr	3703	4	at	at	IN
cord-006860-a3b8hyyr	3703	5	a	a	DT
cord-006860-a3b8hyyr	3703	6	platelet	platelet	NN
cord-006860-a3b8hyyr	3703	7	count	count	NN
cord-006860-a3b8hyyr	3703	8	of	of	IN
cord-006860-a3b8hyyr	3703	9	3x105	3x105	CD
cord-006860-a3b8hyyr	3703	10	/	/	SYM
cord-006860-a3b8hyyr	3703	11	id	id	NN
cord-006860-a3b8hyyr	3703	12	in	in	IN
cord-006860-a3b8hyyr	3703	13	the	the	DT
cord-006860-a3b8hyyr	3703	14	PRP	PRP	NNP
cord-006860-a3b8hyyr	3703	15	,	,	,
cord-006860-a3b8hyyr	3703	16	10	10	CD
cord-006860-a3b8hyyr	3703	17	-6	-6	NNP
cord-006860-a3b8hyyr	3703	18	M	M	NNP
cord-006860-a3b8hyyr	3703	19	ADP	ADP	NNP
cord-006860-a3b8hyyr	3703	20	led	lead	VBD
cord-006860-a3b8hyyr	3703	21	to	to	IN
cord-006860-a3b8hyyr	3703	22	maximal	maximal	JJ
cord-006860-a3b8hyyr	3703	23	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3703	24	in	in	IN
cord-006860-a3b8hyyr	3703	25	uncoated	uncoated	JJ
cord-006860-a3b8hyyr	3703	26	cuvettes	cuvette	NNS
cord-006860-a3b8hyyr	3703	27	,	,	,
cord-006860-a3b8hyyr	3703	28	in	in	IN
cord-006860-a3b8hyyr	3703	29	presence	presence	NN
cord-006860-a3b8hyyr	3703	30	of	of	IN
cord-006860-a3b8hyyr	3703	31	5,5x106	5,5x106	CD
cord-006860-a3b8hyyr	3703	32	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	3703	33	cells	cell	NNS
cord-006860-a3b8hyyr	3703	34	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3703	35	was	be	VBD
cord-006860-a3b8hyyr	3703	36	completely	completely	RB
cord-006860-a3b8hyyr	3703	37	abolished	abolish	VBN
cord-006860-a3b8hyyr	3703	38	,	,	,
cord-006860-a3b8hyyr	3703	39	in	in	IN
cord-006860-a3b8hyyr	3703	40	presence	presence	NN
cord-006860-a3b8hyyr	3703	41	of	of	IN
cord-006860-a3b8hyyr	3703	42	2,75x10	2,75x10	CD
cord-006860-a3b8hyyr	3703	43	"	"	''
cord-006860-a3b8hyyr	3703	44	6	6	CD
cord-006860-a3b8hyyr	3703	45	cells	cell	NNS
cord-006860-a3b8hyyr	3703	46	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3703	47	was	be	VBD
cord-006860-a3b8hyyr	3703	48	decreased	decrease	VBN
cord-006860-a3b8hyyr	3703	49	to	to	IN
cord-006860-a3b8hyyr	3703	50	40	40	CD
cord-006860-a3b8hyyr	3703	51	%	%	NN
cord-006860-a3b8hyyr	3703	52	.	.	.
cord-006860-a3b8hyyr	3704	1	Smooth	smooth	JJ
cord-006860-a3b8hyyr	3704	2	muscle	muscle	NN
cord-006860-a3b8hyyr	3704	3	cells	cell	NNS
cord-006860-a3b8hyyr	3704	4	diminished	diminish	VBD
cord-006860-a3b8hyyr	3704	5	the	the	DT
cord-006860-a3b8hyyr	3704	6	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3704	7	effect	effect	NN
cord-006860-a3b8hyyr	3704	8	of	of	IN
cord-006860-a3b8hyyr	3704	9	0,1	0,1	CD
cord-006860-a3b8hyyr	3704	10	NIH	NIH	NNP
cord-006860-a3b8hyyr	3704	11	Thrombin	Thrombin	NNP
cord-006860-a3b8hyyr	3704	12	to	to	IN
cord-006860-a3b8hyyr	3704	13	67	67	CD
cord-006860-a3b8hyyr	3704	14	%	%	NN
cord-006860-a3b8hyyr	3704	15	when	when	WRB
cord-006860-a3b8hyyr	3704	16	only	only	RB
cord-006860-a3b8hyyr	3704	17	one	one	CD
cord-006860-a3b8hyyr	3704	18	side	side	NN
cord-006860-a3b8hyyr	3704	19	of	of	IN
cord-006860-a3b8hyyr	3704	20	the	the	DT
cord-006860-a3b8hyyr	3704	21	cuvette	cuvette	NN
cord-006860-a3b8hyyr	3704	22	was	be	VBD
cord-006860-a3b8hyyr	3704	23	coated	coat	VBN
cord-006860-a3b8hyyr	3704	24	and	and	CC
cord-006860-a3b8hyyr	3704	25	to	to	IN
cord-006860-a3b8hyyr	3704	26	63	63	CD
cord-006860-a3b8hyyr	3704	27	%	%	NN
cord-006860-a3b8hyyr	3704	28	when	when	WRB
cord-006860-a3b8hyyr	3704	29	both	both	DT
cord-006860-a3b8hyyr	3704	30	sides	side	NNS
cord-006860-a3b8hyyr	3704	31	were	be	VBD
cord-006860-a3b8hyyr	3704	32	coated	coat	VBN
cord-006860-a3b8hyyr	3704	33	.	.	.
cord-006860-a3b8hyyr	3705	1	Endothelium	endothelium	NN
cord-006860-a3b8hyyr	3705	2	could	could	MD
cord-006860-a3b8hyyr	3705	3	not	not	RB
cord-006860-a3b8hyyr	3705	4	inhibit	inhibit	VB
cord-006860-a3b8hyyr	3705	5	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3705	6	induced	induce	VBN
cord-006860-a3b8hyyr	3705	7	by	by	IN
cord-006860-a3b8hyyr	3705	8	2,5	2,5	CD
cord-006860-a3b8hyyr	3705	9	x	x	SYM
cord-006860-a3b8hyyr	3705	10	10	10	CD
cord-006860-a3b8hyyr	3705	11	-6	-6	NNP
cord-006860-a3b8hyyr	3705	12	M	M	NNP
cord-006860-a3b8hyyr	3705	13	ADP	ADP	NNP
cord-006860-a3b8hyyr	3705	14	but	but	CC
cord-006860-a3b8hyyr	3705	15	endothelium	endothelium	NN
cord-006860-a3b8hyyr	3705	16	incubated	incubate	VBN
cord-006860-a3b8hyyr	3705	17	with	with	IN
cord-006860-a3b8hyyr	3705	18	500	500	CD
cord-006860-a3b8hyyr	3705	19	U	U	NNP
cord-006860-a3b8hyyr	3705	20	/	/	SYM
cord-006860-a3b8hyyr	3705	21	ml	ml	NNP
cord-006860-a3b8hyyr	3705	22	TNF	TNF	NNP
cord-006860-a3b8hyyr	3705	23	-	-	:
cord-006860-a3b8hyyr	3705	24	a	a	NN
cord-006860-a3b8hyyr	3705	25	or	or	CC
cord-006860-a3b8hyyr	3705	26	30	30	CD
cord-006860-a3b8hyyr	3705	27	U	u	NN
cord-006860-a3b8hyyr	3705	28	/	/	SYM
cord-006860-a3b8hyyr	3705	29	ml	ml	XX
cord-006860-a3b8hyyr	3705	30	Intedeukin	Intedeukin	NNP
cord-006860-a3b8hyyr	3705	31	-	-	HYPH
cord-006860-a3b8hyyr	3705	32	lfl	lfl	NNP
cord-006860-a3b8hyyr	3705	33	or	or	CC
cord-006860-a3b8hyyr	3705	34	lmM	lmM	NNP
cord-006860-a3b8hyyr	3705	35	L	L	NNP
cord-006860-a3b8hyyr	3705	36	-	-	HYPH
cord-006860-a3b8hyyr	3705	37	Nitro	Nitro	NNP
cord-006860-a3b8hyyr	3705	38	-	-	HYPH
cord-006860-a3b8hyyr	3705	39	Arginin	Arginin	NNP
cord-006860-a3b8hyyr	3705	40	for	for	IN
cord-006860-a3b8hyyr	3705	41	24	24	CD
cord-006860-a3b8hyyr	3705	42	h	h	NN
cord-006860-a3b8hyyr	3705	43	did	do	VBD
cord-006860-a3b8hyyr	3705	44	completely	completely	RB
cord-006860-a3b8hyyr	3705	45	inhibit	inhibit	VB
cord-006860-a3b8hyyr	3705	46	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3705	47	.	.	.
cord-006860-a3b8hyyr	3706	1	Platelets	platelet	NNS
cord-006860-a3b8hyyr	3706	2	become	become	VBP
cord-006860-a3b8hyyr	3706	3	sticky	sticky	JJ
cord-006860-a3b8hyyr	3706	4	and	and	CC
cord-006860-a3b8hyyr	3706	5	adhere	adhere	VB
cord-006860-a3b8hyyr	3706	6	to	to	IN
cord-006860-a3b8hyyr	3706	7	surfaces	surface	NNS
cord-006860-a3b8hyyr	3706	8	or	or	CC
cord-006860-a3b8hyyr	3706	9	to	to	IN
cord-006860-a3b8hyyr	3706	10	another	another	DT
cord-006860-a3b8hyyr	3706	11	without	without	IN
cord-006860-a3b8hyyr	3706	12	contracting	contracting	NN
cord-006860-a3b8hyyr	3706	13	and	and	CC
cord-006860-a3b8hyyr	3706	14	secreting	secreting	NN
cord-006860-a3b8hyyr	3706	15	.	.	.
cord-006860-a3b8hyyr	3707	1	During	during	IN
cord-006860-a3b8hyyr	3707	2	maturation	maturation	NN
cord-006860-a3b8hyyr	3707	3	of	of	IN
cord-006860-a3b8hyyr	3707	4	megakaryocytes	megakaryocyte	NNS
cord-006860-a3b8hyyr	3707	5	finally	finally	RB
cord-006860-a3b8hyyr	3707	6	platelets	platelet	NNS
cord-006860-a3b8hyyr	3707	7	lost	lose	VBD
cord-006860-a3b8hyyr	3707	8	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3707	9	genomic	genomic	JJ
cord-006860-a3b8hyyr	3707	10	nuclear	nuclear	JJ
cord-006860-a3b8hyyr	3707	11	message	message	NN
cord-006860-a3b8hyyr	3707	12	.	.	.
cord-006860-a3b8hyyr	3708	1	Only	only	RB
cord-006860-a3b8hyyr	3708	2	mitochondrial	mitochondrial	JJ
cord-006860-a3b8hyyr	3708	3	DNA	dna	NN
cord-006860-a3b8hyyr	3708	4	of	of	IN
cord-006860-a3b8hyyr	3708	5	platelets	platelet	NNS
cord-006860-a3b8hyyr	3708	6	can	can	MD
cord-006860-a3b8hyyr	3708	7	be	be	VB
cord-006860-a3b8hyyr	3708	8	identified	identify	VBN
cord-006860-a3b8hyyr	3708	9	.	.	.
cord-006860-a3b8hyyr	3709	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3709	2	focused	focus	VBD
cord-006860-a3b8hyyr	3709	3	our	-PRON-	PRP$
cord-006860-a3b8hyyr	3709	4	attention	attention	NN
cord-006860-a3b8hyyr	3709	5	on	on	IN
cord-006860-a3b8hyyr	3709	6	the	the	DT
cord-006860-a3b8hyyr	3709	7	impact	impact	NN
cord-006860-a3b8hyyr	3709	8	of	of	IN
cord-006860-a3b8hyyr	3709	9	mitochondrial	mitochondrial	JJ
cord-006860-a3b8hyyr	3709	10	DNA	dna	NN
cord-006860-a3b8hyyr	3709	11	and	and	CC
cord-006860-a3b8hyyr	3709	12	the	the	DT
cord-006860-a3b8hyyr	3709	13	mitochondrial	mitochondrial	JJ
cord-006860-a3b8hyyr	3709	14	transscriptive	transscriptive	JJ
cord-006860-a3b8hyyr	3709	15	mechausisms	mechausism	NNS
cord-006860-a3b8hyyr	3709	16	during	during	IN
cord-006860-a3b8hyyr	3709	17	platelet	platelet	NN
cord-006860-a3b8hyyr	3709	18	activation	activation	NN
cord-006860-a3b8hyyr	3709	19	in	in	IN
cord-006860-a3b8hyyr	3709	20	normals	normal	NNS
cord-006860-a3b8hyyr	3709	21	.	.	.
cord-006860-a3b8hyyr	3710	1	Materials	material	NNS
cord-006860-a3b8hyyr	3710	2	and	and	CC
cord-006860-a3b8hyyr	3710	3	methods	method	NNS
cord-006860-a3b8hyyr	3710	4	:	:	:
cord-006860-a3b8hyyr	3710	5	Leucocyte	leucocyte	RB
cord-006860-a3b8hyyr	3710	6	free	free	JJ
cord-006860-a3b8hyyr	3710	7	(	(	-LRB-
cord-006860-a3b8hyyr	3710	8	Nagentte	Nagentte	NNP
cord-006860-a3b8hyyr	3710	9	chamber	chamber	NN
cord-006860-a3b8hyyr	3710	10	,	,	,
cord-006860-a3b8hyyr	3710	11	flow	flow	NN
cord-006860-a3b8hyyr	3710	12	cytometric	cytometric	NNP
cord-006860-a3b8hyyr	3710	13	analysis	analysis	NN
cord-006860-a3b8hyyr	3710	14	)	)	-RRB-
cord-006860-a3b8hyyr	3711	1	platelet	platelet	JJ
cord-006860-a3b8hyyr	3711	2	rich	rich	JJ
cord-006860-a3b8hyyr	3711	3	plasma	plasma	NN
cord-006860-a3b8hyyr	3711	4	or	or	CC
cord-006860-a3b8hyyr	3711	5	platelet	platelet	NN
cord-006860-a3b8hyyr	3711	6	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	3712	1	a_~er	a_~er	NNP
cord-006860-a3b8hyyr	3712	2	hemapheresis	hemapheresis	NNP
cord-006860-a3b8hyyr	3712	3	were	be	VBD
cord-006860-a3b8hyyr	3712	4	filtered	filter	VBN
cord-006860-a3b8hyyr	3712	5	by	by	IN
cord-006860-a3b8hyyr	3712	6	PALL	PALL	NNP
cord-006860-a3b8hyyr	3712	7	100	100	CD
cord-006860-a3b8hyyr	3712	8	leucocyte	leucocyte	NNP
cord-006860-a3b8hyyr	3712	9	filters	filter	NNS
cord-006860-a3b8hyyr	3712	10	.	.	.
cord-006860-a3b8hyyr	3713	1	The	the	DT
cord-006860-a3b8hyyr	3713	2	influence	influence	NN
cord-006860-a3b8hyyr	3713	3	of	of	IN
cord-006860-a3b8hyyr	3713	4	different	different	JJ
cord-006860-a3b8hyyr	3713	5	anticoagulants	anticoagulant	NNS
cord-006860-a3b8hyyr	3713	6	(	(	-LRB-
cord-006860-a3b8hyyr	3713	7	commercially	commercially	RB
cord-006860-a3b8hyyr	3713	8	available	available	JJ
cord-006860-a3b8hyyr	3713	9	Sarstedt	Sarstedt	NNP
cord-006860-a3b8hyyr	3713	10	tubes	tube	NNS
cord-006860-a3b8hyyr	3713	11	containing	contain	VBG
cord-006860-a3b8hyyr	3713	12	citrate	citrate	NNP
cord-006860-a3b8hyyr	3713	13	,	,	,
cord-006860-a3b8hyyr	3713	14	heparim	heparim	NNP
cord-006860-a3b8hyyr	3713	15	EDTA	EDTA	NNP
cord-006860-a3b8hyyr	3713	16	and	and	CC
cord-006860-a3b8hyyr	3713	17	500	500	CD
cord-006860-a3b8hyyr	3713	18	ATU	ATU	NNP
cord-006860-a3b8hyyr	3713	19	/	/	,
cord-006860-a3b8hyyr	3713	20	ml	ml	XX
cord-006860-a3b8hyyr	3713	21	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3713	22	Wacker	Wacker	NNP
cord-006860-a3b8hyyr	3713	23	)	)	-RRB-
cord-006860-a3b8hyyr	3713	24	was	be	VBD
cord-006860-a3b8hyyr	3713	25	examined	examine	VBN
cord-006860-a3b8hyyr	3713	26	.	.	.
cord-006860-a3b8hyyr	3714	1	Activation	activation	NN
cord-006860-a3b8hyyr	3714	2	was	be	VBD
cord-006860-a3b8hyyr	3714	3	due	due	JJ
cord-006860-a3b8hyyr	3714	4	to	to	IN
cord-006860-a3b8hyyr	3714	5	a	a	DT
cord-006860-a3b8hyyr	3714	6	60	60	CD
cord-006860-a3b8hyyr	3714	7	nun	nun	NN
cord-006860-a3b8hyyr	3714	8	.	.	.
cord-006860-a3b8hyyr	3715	1	hemapheresis	hemapheresis	NNP
cord-006860-a3b8hyyr	3715	2	procedure	procedure	NNP
cord-006860-a3b8hyyr	3715	3	(	(	-LRB-
cord-006860-a3b8hyyr	3715	4	3	3	CD
cord-006860-a3b8hyyr	3715	5	-	-	HYPH
cord-006860-a3b8hyyr	3715	6	5fold	5fold	JJ
cord-006860-a3b8hyyr	3715	7	increase	increase	NN
cord-006860-a3b8hyyr	3715	8	of	of	IN
cord-006860-a3b8hyyr	3715	9	CD	CD	NNP
cord-006860-a3b8hyyr	3715	10	62	62	CD
cord-006860-a3b8hyyr	3715	11	,	,	,
cord-006860-a3b8hyyr	3715	12	CD	CD	NNP
cord-006860-a3b8hyyr	3715	13	63	63	CD
cord-006860-a3b8hyyr	3715	14	)	)	-RRB-
cord-006860-a3b8hyyr	3715	15	and	and	CC
cord-006860-a3b8hyyr	3715	16	ex	ex	NNP
cord-006860-a3b8hyyr	3715	17	rive	rive	NNP
cord-006860-a3b8hyyr	3715	18	stmaulation	stmaulation	NN
cord-006860-a3b8hyyr	3715	19	due	due	IN
cord-006860-a3b8hyyr	3715	20	to	to	IN
cord-006860-a3b8hyyr	3716	1	4	4	LS
cord-006860-a3b8hyyr	3716	2	NIY	NIY	NNP
cord-006860-a3b8hyyr	3716	3	U	U	NNP
cord-006860-a3b8hyyr	3716	4	/	/	SYM
cord-006860-a3b8hyyr	3716	5	ml	ml	XX
cord-006860-a3b8hyyr	3716	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3716	7	,	,	,
cord-006860-a3b8hyyr	3716	8	0.025	0.025	CD
cord-006860-a3b8hyyr	3716	9	m	m	NN
cord-006860-a3b8hyyr	3716	10	CaC12	cac12	NN
cord-006860-a3b8hyyr	3716	11	or	or	CC
cord-006860-a3b8hyyr	3716	12	combmatious	combmatious	NNP
cord-006860-a3b8hyyr	3716	13	.	.	.
cord-006860-a3b8hyyr	3717	1	The	the	DT
cord-006860-a3b8hyyr	3717	2	guanidiurn	guanidiurn	NN
cord-006860-a3b8hyyr	3717	3	method	method	NN
cord-006860-a3b8hyyr	3717	4	for	for	IN
cord-006860-a3b8hyyr	3717	5	total	total	JJ
cord-006860-a3b8hyyr	3717	6	RNA	RNA	NNP
cord-006860-a3b8hyyr	3717	7	preparation	preparation	NN
cord-006860-a3b8hyyr	3717	8	were	be	VBD
cord-006860-a3b8hyyr	3717	9	used	use	VBN
cord-006860-a3b8hyyr	3717	10	according	accord	VBG
cord-006860-a3b8hyyr	3717	11	to	to	IN
cord-006860-a3b8hyyr	3717	12	T.	T.	NNP
cord-006860-a3b8hyyr	3717	13	Brown	Brown	NNP
cord-006860-a3b8hyyr	3717	14	:	:	:
cord-006860-a3b8hyyr	3717	15	Current	current	JJ
cord-006860-a3b8hyyr	3717	16	protocols	protocol	NNS
cord-006860-a3b8hyyr	3717	17	in	in	IN
cord-006860-a3b8hyyr	3717	18	molecular	molecular	JJ
cord-006860-a3b8hyyr	3717	19	biology	biology	NN
cord-006860-a3b8hyyr	3717	20	4.21	4.21	CD
cord-006860-a3b8hyyr	3717	21	-	-	SYM
cord-006860-a3b8hyyr	3717	22	4.9.14,1991	4.9.14,1991	CD
cord-006860-a3b8hyyr	3717	23	.	.	.
cord-006860-a3b8hyyr	3718	1	Different	different	JJ
cord-006860-a3b8hyyr	3718	2	primers	primer	NNS
cord-006860-a3b8hyyr	3718	3	of	of	IN
cord-006860-a3b8hyyr	3718	4	mitochondrial	mitochondrial	JJ
cord-006860-a3b8hyyr	3718	5	genome	genome	NN
cord-006860-a3b8hyyr	3718	6	(	(	-LRB-
cord-006860-a3b8hyyr	3718	7	e.g.	e.g.	RB
cord-006860-a3b8hyyr	3718	8	cytochrome	cytochrome	NN
cord-006860-a3b8hyyr	3718	9	b	b	NN
cord-006860-a3b8hyyr	3718	10	and	and	CC
cord-006860-a3b8hyyr	3718	11	ATPase	ATPase	NNP
cord-006860-a3b8hyyr	3718	12	)	)	-RRB-
cord-006860-a3b8hyyr	3718	13	were	be	VBD
cord-006860-a3b8hyyr	3718	14	prepared	prepare	VBN
cord-006860-a3b8hyyr	3718	15	using	use	VBG
cord-006860-a3b8hyyr	3718	16	PCR	PCR	NNP
cord-006860-a3b8hyyr	3718	17	and	and	CC
cord-006860-a3b8hyyr	3718	18	mitochondrial	mitochondrial	JJ
cord-006860-a3b8hyyr	3718	19	transscription	transscription	NN
cord-006860-a3b8hyyr	3718	20	was	be	VBD
cord-006860-a3b8hyyr	3718	21	examined	examine	VBN
cord-006860-a3b8hyyr	3718	22	using	use	VBG
cord-006860-a3b8hyyr	3718	23	Northern	northern	JJ
cord-006860-a3b8hyyr	3718	24	-	-	HYPH
cord-006860-a3b8hyyr	3718	25	Blot	blot	NN
cord-006860-a3b8hyyr	3718	26	-	-	HYPH
cord-006860-a3b8hyyr	3718	27	technique	technique	NN
cord-006860-a3b8hyyr	3718	28	.	.	.
cord-006860-a3b8hyyr	3719	1	Results	result	NNS
cord-006860-a3b8hyyr	3719	2	:	:	:
cord-006860-a3b8hyyr	3720	1	1	1	LS
cord-006860-a3b8hyyr	3720	2	.	.	.
cord-006860-a3b8hyyr	3720	3	,	,	,
cord-006860-a3b8hyyr	3720	4	There	there	EX
cord-006860-a3b8hyyr	3720	5	is	be	VBZ
cord-006860-a3b8hyyr	3720	6	less	less	JJR
cord-006860-a3b8hyyr	3720	7	activation	activation	NN
cord-006860-a3b8hyyr	3720	8	of	of	IN
cord-006860-a3b8hyyr	3720	9	mitochondrias	mitochondria	NNS
cord-006860-a3b8hyyr	3720	10	using	use	VBG
cord-006860-a3b8hyyr	3720	11	hirudin	hirudin	NN
cord-006860-a3b8hyyr	3720	12	anticoagnlation	anticoagnlation	NN
cord-006860-a3b8hyyr	3720	13	,	,	,
cord-006860-a3b8hyyr	3720	14	but	but	CC
cord-006860-a3b8hyyr	3720	15	a	a	DT
cord-006860-a3b8hyyr	3720	16	2fold	2fold	CD
cord-006860-a3b8hyyr	3720	17	increase	increase	NN
cord-006860-a3b8hyyr	3720	18	of	of	IN
cord-006860-a3b8hyyr	3720	19	mitochoindrial	mitochoindrial	NNP
cord-006860-a3b8hyyr	3720	20	RNA	RNA	NNP
cord-006860-a3b8hyyr	3720	21	content	content	NN
cord-006860-a3b8hyyr	3720	22	in	in	IN
cord-006860-a3b8hyyr	3720	23	heparinized	heparinize	VBN
cord-006860-a3b8hyyr	3720	24	samples	sample	NNS
cord-006860-a3b8hyyr	3720	25	.	.	.
cord-006860-a3b8hyyr	3721	1	2	2	LS
cord-006860-a3b8hyyr	3721	2	.	.	.
cord-006860-a3b8hyyr	3722	1	,	,	,
cord-006860-a3b8hyyr	3722	2	Stimulation	stimulation	NN
cord-006860-a3b8hyyr	3722	3	with	with	IN
cord-006860-a3b8hyyr	3722	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3722	5	leas	leas	NNP
cord-006860-a3b8hyyr	3722	6	to	to	IN
cord-006860-a3b8hyyr	3722	7	an	an	DT
cord-006860-a3b8hyyr	3722	8	increase	increase	NN
cord-006860-a3b8hyyr	3722	9	to	to	IN
cord-006860-a3b8hyyr	3722	10	5.5	5.5	CD
cord-006860-a3b8hyyr	3722	11	E	e	NN
cord-006860-a3b8hyyr	3722	12	-	-	HYPH
cord-006860-a3b8hyyr	3722	13	l0	l0	NNP
cord-006860-a3b8hyyr	3722	14	RNA	RNA	NNP
cord-006860-a3b8hyyr	3722	15	btg	btg	NNP
cord-006860-a3b8hyyr	3722	16	/	/	SYM
cord-006860-a3b8hyyr	3722	17	platelet	platelet	NN
cord-006860-a3b8hyyr	3722	18	,	,	,
cord-006860-a3b8hyyr	3722	19	compared	compare	VBN
cord-006860-a3b8hyyr	3722	20	to	to	IN
cord-006860-a3b8hyyr	3722	21	4.7	4.7	CD
cord-006860-a3b8hyyr	3722	22	-4.8	-4.8	:
cord-006860-a3b8hyyr	3722	23	E-10	E-10	NNP
cord-006860-a3b8hyyr	3722	24	RNA	RNA	NNP
cord-006860-a3b8hyyr	3722	25	~tg	~tg	NN
cord-006860-a3b8hyyr	3722	26	/	/	SYM
cord-006860-a3b8hyyr	3722	27	platelet	platelet	NN
cord-006860-a3b8hyyr	3722	28	under	under	IN
cord-006860-a3b8hyyr	3722	29	unstimulated	unstimulated	JJ
cord-006860-a3b8hyyr	3722	30	conditions	condition	NNS
cord-006860-a3b8hyyr	3722	31	..	..	.
cord-006860-a3b8hyyr	3723	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	3723	2	:	:	:
cord-006860-a3b8hyyr	3724	1	There	there	EX
cord-006860-a3b8hyyr	3724	2	is	be	VBZ
cord-006860-a3b8hyyr	3724	3	evidence	evidence	NN
cord-006860-a3b8hyyr	3724	4	for	for	IN
cord-006860-a3b8hyyr	3724	5	the	the	DT
cord-006860-a3b8hyyr	3724	6	importance	importance	NN
cord-006860-a3b8hyyr	3724	7	of	of	IN
cord-006860-a3b8hyyr	3724	8	platelets	platelet	NNS
cord-006860-a3b8hyyr	3724	9	mitochondrial	mitochondrial	NN
cord-006860-a3b8hyyr	3724	10	DNA	DNA	NNP
cord-006860-a3b8hyyr	3724	11	and	and	CC
cord-006860-a3b8hyyr	3724	12	mitochondrinl	mitochondrinl	NNS
cord-006860-a3b8hyyr	3724	13	transsefiption	transsefiption	NN
cord-006860-a3b8hyyr	3724	14	in	in	IN
cord-006860-a3b8hyyr	3724	15	regulation	regulation	NN
cord-006860-a3b8hyyr	3724	16	of	of	IN
cord-006860-a3b8hyyr	3724	17	cytosceleton	cytosceleton	NN
cord-006860-a3b8hyyr	3724	18	and	and	CC
cord-006860-a3b8hyyr	3724	19	platelet	platelet	NN
cord-006860-a3b8hyyr	3724	20	activation	activation	NN
cord-006860-a3b8hyyr	3724	21	.	.	.
cord-006860-a3b8hyyr	3725	1	Thrombospondin-1	Thrombospondin-1	NNP
cord-006860-a3b8hyyr	3726	1	(	(	-LRB-
cord-006860-a3b8hyyr	3726	2	TSP-1	TSP-1	NNP
cord-006860-a3b8hyyr	3726	3	)	)	-RRB-
cord-006860-a3b8hyyr	3726	4	is	be	VBZ
cord-006860-a3b8hyyr	3726	5	a	a	DT
cord-006860-a3b8hyyr	3726	6	large	large	JJ
cord-006860-a3b8hyyr	3726	7	homotrimeric	homotrimeric	JJ
cord-006860-a3b8hyyr	3726	8	glycoprotein	glycoprotein	NN
cord-006860-a3b8hyyr	3726	9	originally	originally	RB
cord-006860-a3b8hyyr	3726	10	identified	identify	VBN
cord-006860-a3b8hyyr	3726	11	as	as	IN
cord-006860-a3b8hyyr	3726	12	a	a	DT
cord-006860-a3b8hyyr	3726	13	platelet	platelet	NN
cord-006860-a3b8hyyr	3726	14	alpha	alpha	NN
cord-006860-a3b8hyyr	3726	15	-	-	HYPH
cord-006860-a3b8hyyr	3726	16	granule	granule	NN
cord-006860-a3b8hyyr	3726	17	component	component	NN
cord-006860-a3b8hyyr	3726	18	.	.	.
cord-006860-a3b8hyyr	3727	1	The	the	DT
cord-006860-a3b8hyyr	3727	2	investigation	investigation	NN
cord-006860-a3b8hyyr	3727	3	of	of	IN
cord-006860-a3b8hyyr	3727	4	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3727	5	putative	putative	JJ
cord-006860-a3b8hyyr	3727	6	role	role	NN
cord-006860-a3b8hyyr	3727	7	in	in	IN
cord-006860-a3b8hyyr	3727	8	a	a	DT
cord-006860-a3b8hyyr	3727	9	variety	variety	NN
cord-006860-a3b8hyyr	3727	10	of	of	IN
cord-006860-a3b8hyyr	3727	11	pathophysiologies	pathophysiologie	NNS
cord-006860-a3b8hyyr	3727	12	like	like	IN
cord-006860-a3b8hyyr	3727	13	haemostatic	haemostatic	JJ
cord-006860-a3b8hyyr	3727	14	disturbance	disturbance	NN
cord-006860-a3b8hyyr	3727	15	,	,	,
cord-006860-a3b8hyyr	3727	16	malignancy	malignancy	NN
cord-006860-a3b8hyyr	3727	17	and	and	CC
cord-006860-a3b8hyyr	3727	18	wound	wound	JJ
cord-006860-a3b8hyyr	3727	19	healing	healing	NN
cord-006860-a3b8hyyr	3727	20	requires	require	VBZ
cord-006860-a3b8hyyr	3727	21	specific	specific	JJ
cord-006860-a3b8hyyr	3727	22	laboratory	laboratory	NN
cord-006860-a3b8hyyr	3727	23	reagents	reagent	NNS
cord-006860-a3b8hyyr	3727	24	.	.	.
cord-006860-a3b8hyyr	3728	1	Monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	3728	2	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3728	3	are	be	VBP
cord-006860-a3b8hyyr	3728	4	one	one	CD
cord-006860-a3b8hyyr	3728	5	of	of	IN
cord-006860-a3b8hyyr	3728	6	the	the	DT
cord-006860-a3b8hyyr	3728	7	most	most	RBS
cord-006860-a3b8hyyr	3728	8	powerful	powerful	JJ
cord-006860-a3b8hyyr	3728	9	of	of	IN
cord-006860-a3b8hyyr	3728	10	these	these	DT
cord-006860-a3b8hyyr	3728	11	reagents	reagent	NNS
cord-006860-a3b8hyyr	3728	12	.	.	.
cord-006860-a3b8hyyr	3729	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	3729	2	,	,	,
cord-006860-a3b8hyyr	3729	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	3729	4	purified	purify	VBD
cord-006860-a3b8hyyr	3729	5	human	human	NN
cord-006860-a3b8hyyr	3729	6	TSP-1	TSP-1	NNP
cord-006860-a3b8hyyr	3729	7	from	from	IN
cord-006860-a3b8hyyr	3729	8	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3729	9	-	-	HYPH
cord-006860-a3b8hyyr	3729	10	stimulated	stimulate	VBN
cord-006860-a3b8hyyr	3729	11	platelets	platelet	NNS
cord-006860-a3b8hyyr	3729	12	using	use	VBG
cord-006860-a3b8hyyr	3729	13	affinity	affinity	NN
cord-006860-a3b8hyyr	3729	14	chromatography	chromatography	NN
cord-006860-a3b8hyyr	3729	15	to	to	TO
cord-006860-a3b8hyyr	3729	16	generate	generate	VB
cord-006860-a3b8hyyr	3729	17	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	3729	18	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3729	19	in	in	IN
cord-006860-a3b8hyyr	3729	20	mice	mouse	NNS
cord-006860-a3b8hyyr	3729	21	.	.	.
cord-006860-a3b8hyyr	3730	1	A	a	DT
cord-006860-a3b8hyyr	3730	2	subclass	subclass	NN
cord-006860-a3b8hyyr	3730	3	IgG	igg	NN
cord-006860-a3b8hyyr	3730	4	1	1	CD
cord-006860-a3b8hyyr	3730	5	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	3730	6	antibody	antibody	NN
cord-006860-a3b8hyyr	3730	7	designated	designate	VBN
cord-006860-a3b8hyyr	3730	8	48.42	48.42	CD
cord-006860-a3b8hyyr	3730	9	was	be	VBD
cord-006860-a3b8hyyr	3730	10	purified	purify	VBN
cord-006860-a3b8hyyr	3730	11	from	from	IN
cord-006860-a3b8hyyr	3730	12	ascitic	ascitic	JJ
cord-006860-a3b8hyyr	3730	13	fluid	fluid	NN
cord-006860-a3b8hyyr	3730	14	and	and	CC
cord-006860-a3b8hyyr	3730	15	further	further	RB
cord-006860-a3b8hyyr	3730	16	characterised	characterise	VBN
cord-006860-a3b8hyyr	3730	17	.	.	.
cord-006860-a3b8hyyr	3731	1	Western	western	JJ
cord-006860-a3b8hyyr	3731	2	blot	blot	NN
cord-006860-a3b8hyyr	3731	3	experiments	experiment	NNS
cord-006860-a3b8hyyr	3731	4	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	3731	5	that	that	IN
cord-006860-a3b8hyyr	3731	6	this	this	DT
cord-006860-a3b8hyyr	3731	7	antibody	antibody	NN
cord-006860-a3b8hyyr	3731	8	reacted	react	VBD
cord-006860-a3b8hyyr	3731	9	only	only	RB
cord-006860-a3b8hyyr	3731	10	with	with	IN
cord-006860-a3b8hyyr	3731	11	the	the	DT
cord-006860-a3b8hyyr	3731	12	unreduced	unreduced	JJ
cord-006860-a3b8hyyr	3731	13	molecule	molecule	NN
cord-006860-a3b8hyyr	3731	14	whereas	whereas	IN
cord-006860-a3b8hyyr	3731	15	the	the	DT
cord-006860-a3b8hyyr	3731	16	TSP-1	TSP-1	NNP
cord-006860-a3b8hyyr	3731	17	subunit	subunit	NN
cord-006860-a3b8hyyr	3731	18	chain	chain	NN
cord-006860-a3b8hyyr	3731	19	was	be	VBD
cord-006860-a3b8hyyr	3731	20	not	not	RB
cord-006860-a3b8hyyr	3731	21	recognised	recognise	VBN
cord-006860-a3b8hyyr	3731	22	.	.	.
cord-006860-a3b8hyyr	3732	1	No	no	DT
cord-006860-a3b8hyyr	3732	2	cross	cross	NN
cord-006860-a3b8hyyr	3732	3	-	-	NNS
cord-006860-a3b8hyyr	3732	4	reactivities	reactivity	NNS
cord-006860-a3b8hyyr	3732	5	with	with	IN
cord-006860-a3b8hyyr	3732	6	human	human	JJ
cord-006860-a3b8hyyr	3732	7	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3732	8	,	,	,
cord-006860-a3b8hyyr	3732	9	fibronectin	fibronectin	NN
cord-006860-a3b8hyyr	3732	10	,	,	,
cord-006860-a3b8hyyr	3732	11	vitronectin	vitronectin	NNP
cord-006860-a3b8hyyr	3732	12	and	and	CC
cord-006860-a3b8hyyr	3732	13	von	von	NNP
cord-006860-a3b8hyyr	3732	14	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	3732	15	factor	factor	NN
cord-006860-a3b8hyyr	3732	16	were	be	VBD
cord-006860-a3b8hyyr	3732	17	found	find	VBN
cord-006860-a3b8hyyr	3732	18	.	.	.
cord-006860-a3b8hyyr	3733	1	Preliminary	preliminary	JJ
cord-006860-a3b8hyyr	3733	2	results	result	NNS
cord-006860-a3b8hyyr	3733	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	3733	4	that	that	IN
cord-006860-a3b8hyyr	3733	5	the	the	DT
cord-006860-a3b8hyyr	3733	6	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	3733	7	antibody	antibody	NN
cord-006860-a3b8hyyr	3733	8	48.42	48.42	CD
cord-006860-a3b8hyyr	3733	9	can	can	MD
cord-006860-a3b8hyyr	3733	10	be	be	VB
cord-006860-a3b8hyyr	3733	11	used	use	VBN
cord-006860-a3b8hyyr	3733	12	to	to	TO
cord-006860-a3b8hyyr	3733	13	investigate	investigate	VB
cord-006860-a3b8hyyr	3733	14	TSP-1	TSP-1	NNP
cord-006860-a3b8hyyr	3733	15	function	function	NN
cord-006860-a3b8hyyr	3733	16	in	in	IN
cord-006860-a3b8hyyr	3733	17	several	several	JJ
cord-006860-a3b8hyyr	3733	18	assays	assay	NNS
cord-006860-a3b8hyyr	3733	19	including	include	VBG
cord-006860-a3b8hyyr	3733	20	immunocytochemistry	immunocytochemistry	NN
cord-006860-a3b8hyyr	3733	21	and	and	CC
cord-006860-a3b8hyyr	3733	22	cell	cell	NN
cord-006860-a3b8hyyr	3733	23	adhesion	adhesion	NN
cord-006860-a3b8hyyr	3733	24	as	as	IN
cord-006860-a3b8hyyr	3733	25	has	have	VBZ
cord-006860-a3b8hyyr	3733	26	been	be	VBN
cord-006860-a3b8hyyr	3733	27	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	3733	28	for	for	IN
cord-006860-a3b8hyyr	3733	29	HL-60	HL-60	NNP
cord-006860-a3b8hyyr	3733	30	cells	cell	NNS
cord-006860-a3b8hyyr	3733	31	.	.	.
cord-006860-a3b8hyyr	3734	1	In	in	IN
cord-006860-a3b8hyyr	3734	2	addition	addition	NN
cord-006860-a3b8hyyr	3734	3	,	,	,
cord-006860-a3b8hyyr	3734	4	a	a	DT
cord-006860-a3b8hyyr	3734	5	sandwich	sandwich	NN
cord-006860-a3b8hyyr	3734	6	enzyme	enzyme	NN
cord-006860-a3b8hyyr	3734	7	immunoassay	immunoassay	NN
cord-006860-a3b8hyyr	3734	8	was	be	VBD
cord-006860-a3b8hyyr	3734	9	developed	develop	VBN
cord-006860-a3b8hyyr	3734	10	using	use	VBG
cord-006860-a3b8hyyr	3734	11	goat	goat	NN
cord-006860-a3b8hyyr	3734	12	-	-	HYPH
cord-006860-a3b8hyyr	3734	13	antihuman	antihuman	NN
cord-006860-a3b8hyyr	3734	14	TSP-1	TSP-1	NNP
cord-006860-a3b8hyyr	3734	15	IgG	igg	NN
cord-006860-a3b8hyyr	3734	16	and	and	CC
cord-006860-a3b8hyyr	3734	17	derivatised	derivatise	VBD
cord-006860-a3b8hyyr	3734	18	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	3734	19	antibody	antibody	NN
cord-006860-a3b8hyyr	3734	20	48.42	48.42	CD
cord-006860-a3b8hyyr	3734	21	(	(	-LRB-
cord-006860-a3b8hyyr	3734	22	peroxidase	peroxidase	NN
cord-006860-a3b8hyyr	3734	23	,	,	,
cord-006860-a3b8hyyr	3734	24	biotin	biotin	NN
cord-006860-a3b8hyyr	3734	25	)	)	-RRB-
cord-006860-a3b8hyyr	3734	26	as	as	IN
cord-006860-a3b8hyyr	3734	27	a	a	DT
cord-006860-a3b8hyyr	3734	28	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	3734	29	method	method	NN
cord-006860-a3b8hyyr	3734	30	for	for	IN
cord-006860-a3b8hyyr	3734	31	detection	detection	NN
cord-006860-a3b8hyyr	3734	32	of	of	IN
cord-006860-a3b8hyyr	3734	33	TSP-1	TSP-1	NNP
cord-006860-a3b8hyyr	3734	34	in	in	IN
cord-006860-a3b8hyyr	3734	35	human	human	JJ
cord-006860-a3b8hyyr	3734	36	body	body	NN
cord-006860-a3b8hyyr	3734	37	fluids	fluid	NNS
cord-006860-a3b8hyyr	3734	38	.	.	.
cord-006860-a3b8hyyr	3735	1	In	in	IN
cord-006860-a3b8hyyr	3735	2	the	the	DT
cord-006860-a3b8hyyr	3735	3	following	follow	VBG
cord-006860-a3b8hyyr	3735	4	study	study	NN
cord-006860-a3b8hyyr	3735	5	the	the	DT
cord-006860-a3b8hyyr	3735	6	expression	expression	NN
cord-006860-a3b8hyyr	3735	7	of	of	IN
cord-006860-a3b8hyyr	3735	8	the	the	DT
cord-006860-a3b8hyyr	3735	9	platelet	platelet	NN
cord-006860-a3b8hyyr	3735	10	antigen	antigen	NN
cord-006860-a3b8hyyr	3735	11	(	(	-LRB-
cord-006860-a3b8hyyr	3735	12	CD62P	CD62P	NNP
cord-006860-a3b8hyyr	3735	13	)	)	-RRB-
cord-006860-a3b8hyyr	3735	14	and	and	CC
cord-006860-a3b8hyyr	3735	15	the	the	DT
cord-006860-a3b8hyyr	3735	16	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	3735	17	antigen	antigen	NN
cord-006860-a3b8hyyr	3735	18	(	(	-LRB-
cord-006860-a3b8hyyr	3735	19	CDllb	CDllb	NNP
cord-006860-a3b8hyyr	3735	20	)	)	-RRB-
cord-006860-a3b8hyyr	3735	21	were	be	VBD
cord-006860-a3b8hyyr	3735	22	measured	measure	VBN
cord-006860-a3b8hyyr	3735	23	in	in	IN
cord-006860-a3b8hyyr	3735	24	whole	whole	JJ
cord-006860-a3b8hyyr	3735	25	blood	blood	NN
cord-006860-a3b8hyyr	3735	26	,	,	,
cord-006860-a3b8hyyr	3735	27	in	in	IN
cord-006860-a3b8hyyr	3735	28	addition	addition	NN
cord-006860-a3b8hyyr	3735	29	to	to	IN
cord-006860-a3b8hyyr	3735	30	platelet	platelet	NN
cord-006860-a3b8hyyr	3735	31	-	-	HYPH
cord-006860-a3b8hyyr	3735	32	leukoeyte	leukoeyte	JJ
cord-006860-a3b8hyyr	3735	33	adhesion	adhesion	NN
cord-006860-a3b8hyyr	3735	34	(	(	-LRB-
cord-006860-a3b8hyyr	3735	35	rosette	rosette	NN
cord-006860-a3b8hyyr	3735	36	formation	formation	NN
cord-006860-a3b8hyyr	3735	37	)	)	-RRB-
cord-006860-a3b8hyyr	3735	38	by	by	IN
cord-006860-a3b8hyyr	3735	39	means	mean	NNS
cord-006860-a3b8hyyr	3735	40	of	of	IN
cord-006860-a3b8hyyr	3735	41	multicolour	multicolour	NN
cord-006860-a3b8hyyr	3735	42	fluorescent	fluorescent	NN
cord-006860-a3b8hyyr	3735	43	labelling	labelling	NN
cord-006860-a3b8hyyr	3735	44	(	(	-LRB-
cord-006860-a3b8hyyr	3735	45	CD45	CD45	NNP
cord-006860-a3b8hyyr	3735	46	,	,	,
cord-006860-a3b8hyyr	3735	47	CD14	CD14	NNP
cord-006860-a3b8hyyr	3735	48	,	,	,
cord-006860-a3b8hyyr	3735	49	CD42a	CD42a	NNP
cord-006860-a3b8hyyr	3735	50	)	)	-RRB-
cord-006860-a3b8hyyr	3735	51	.	.	.
cord-006860-a3b8hyyr	3736	1	The	the	DT
cord-006860-a3b8hyyr	3736	2	measurements	measurement	NNS
cord-006860-a3b8hyyr	3736	3	were	be	VBD
cord-006860-a3b8hyyr	3736	4	carded	card	VBN
cord-006860-a3b8hyyr	3736	5	out	out	RP
cord-006860-a3b8hyyr	3736	6	both	both	DT
cord-006860-a3b8hyyr	3736	7	in	in	IN
cord-006860-a3b8hyyr	3736	8	freshly	freshly	RB
cord-006860-a3b8hyyr	3736	9	drawn	draw	VBN
cord-006860-a3b8hyyr	3736	10	whole	whole	JJ
cord-006860-a3b8hyyr	3736	11	blood	blood	NN
cord-006860-a3b8hyyr	3736	12	which	which	WDT
cord-006860-a3b8hyyr	3736	13	had	have	VBD
cord-006860-a3b8hyyr	3736	14	been	be	VBN
cord-006860-a3b8hyyr	3736	15	antieoagulated	antieoagulate	VBN
cord-006860-a3b8hyyr	3736	16	with	with	IN
cord-006860-a3b8hyyr	3736	17	different	different	JJ
cord-006860-a3b8hyyr	3736	18	agents	agent	NNS
cord-006860-a3b8hyyr	3736	19	,	,	,
cord-006860-a3b8hyyr	3736	20	and	and	CC
cord-006860-a3b8hyyr	3736	21	in	in	IN
cord-006860-a3b8hyyr	3736	22	stirred	stir	VBN
cord-006860-a3b8hyyr	3736	23	samples	sample	NNS
cord-006860-a3b8hyyr	3736	24	of	of	IN
cord-006860-a3b8hyyr	3736	25	whole	whole	JJ
cord-006860-a3b8hyyr	3736	26	blood	blood	NN
cord-006860-a3b8hyyr	3736	27	under	under	IN
cord-006860-a3b8hyyr	3736	28	controlled	control	VBN
cord-006860-a3b8hyyr	3736	29	conditions	condition	NNS
cord-006860-a3b8hyyr	3736	30	(	(	-LRB-
cord-006860-a3b8hyyr	3736	31	37	37	CD
cord-006860-a3b8hyyr	3736	32	°	°	NN
cord-006860-a3b8hyyr	3736	33	C	c	NN
cord-006860-a3b8hyyr	3736	34	,	,	,
cord-006860-a3b8hyyr	3736	35	1000	1000	CD
cord-006860-a3b8hyyr	3736	36	rpm	rpm	NN
cord-006860-a3b8hyyr	3736	37	,	,	,
cord-006860-a3b8hyyr	3736	38	different	different	JJ
cord-006860-a3b8hyyr	3736	39	stirring	stirring	NN
cord-006860-a3b8hyyr	3736	40	times	time	NNS
cord-006860-a3b8hyyr	3736	41	)	)	-RRB-
cord-006860-a3b8hyyr	3736	42	.	.	.
cord-006860-a3b8hyyr	3737	1	The	the	DT
cord-006860-a3b8hyyr	3737	2	results	result	NNS
cord-006860-a3b8hyyr	3737	3	are	be	VBP
cord-006860-a3b8hyyr	3737	4	presented	present	VBN
cord-006860-a3b8hyyr	3737	5	as	as	IN
cord-006860-a3b8hyyr	3737	6	the	the	DT
cord-006860-a3b8hyyr	3737	7	percent	percent	NN
cord-006860-a3b8hyyr	3737	8	positive	positive	JJ
cord-006860-a3b8hyyr	3737	9	events	event	NNS
cord-006860-a3b8hyyr	3737	10	in	in	IN
cord-006860-a3b8hyyr	3737	11	each	each	DT
cord-006860-a3b8hyyr	3737	12	gate	gate	NN
cord-006860-a3b8hyyr	3737	13	(	(	-LRB-
cord-006860-a3b8hyyr	3737	14	platelets	platelet	NNS
cord-006860-a3b8hyyr	3737	15	,	,	,
cord-006860-a3b8hyyr	3737	16	leukocytes	leukocyte	NNS
cord-006860-a3b8hyyr	3737	17	-PMNL	-PMNL	.
cord-006860-a3b8hyyr	3737	18	,	,	,
cord-006860-a3b8hyyr	3737	19	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	3737	20	,	,	,
cord-006860-a3b8hyyr	3737	21	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	3737	22	and	and	CC
cord-006860-a3b8hyyr	3737	23	rosettes	rosette	NNS
cord-006860-a3b8hyyr	3737	24	-plateletpositive	-plateletpositive	JJ
cord-006860-a3b8hyyr	3737	25	events	event	NNS
cord-006860-a3b8hyyr	3737	26	in	in	IN
cord-006860-a3b8hyyr	3737	27	the	the	DT
cord-006860-a3b8hyyr	3737	28	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	3737	29	,	,	,
cord-006860-a3b8hyyr	3737	30	monocyte	monocyte	NNP
cord-006860-a3b8hyyr	3737	31	and	and	CC
cord-006860-a3b8hyyr	3737	32	lymphocyte	lymphocyte	NNP
cord-006860-a3b8hyyr	3737	33	gates	gates	NNP
cord-006860-a3b8hyyr	3737	34	)	)	-RRB-
cord-006860-a3b8hyyr	3737	35	,	,	,
cord-006860-a3b8hyyr	3737	36	whose	whose	WP$
cord-006860-a3b8hyyr	3737	37	mean	mean	JJ
cord-006860-a3b8hyyr	3737	38	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	3737	39	is	be	VBZ
cord-006860-a3b8hyyr	3737	40	given	give	VBN
cord-006860-a3b8hyyr	3737	41	in	in	IN
cord-006860-a3b8hyyr	3737	42	addition	addition	NN
cord-006860-a3b8hyyr	3737	43	to	to	IN
cord-006860-a3b8hyyr	3737	44	an	an	DT
cord-006860-a3b8hyyr	3737	45	index	index	NN
cord-006860-a3b8hyyr	3737	46	comprising	comprise	VBG
cord-006860-a3b8hyyr	3737	47	the	the	DT
cord-006860-a3b8hyyr	3737	48	product	product	NN
cord-006860-a3b8hyyr	3737	49	of	of	IN
cord-006860-a3b8hyyr	3737	50	the	the	DT
cord-006860-a3b8hyyr	3737	51	percent	percent	NN
cord-006860-a3b8hyyr	3737	52	positive	positive	JJ
cord-006860-a3b8hyyr	3737	53	events	event	NNS
cord-006860-a3b8hyyr	3737	54	and	and	CC
cord-006860-a3b8hyyr	3737	55	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3737	56	mean	mean	JJ
cord-006860-a3b8hyyr	3737	57	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	3737	58	.	.	.
cord-006860-a3b8hyyr	3738	1	Stirring	stir	VBG
cord-006860-a3b8hyyr	3738	2	(	(	-LRB-
cord-006860-a3b8hyyr	3738	3	max	max	NNP
cord-006860-a3b8hyyr	3738	4	15	15	CD
cord-006860-a3b8hyyr	3738	5	rain	rain	NN
cord-006860-a3b8hyyr	3738	6	)	)	-RRB-
cord-006860-a3b8hyyr	3738	7	induced	induce	VBD
cord-006860-a3b8hyyr	3738	8	an	an	DT
cord-006860-a3b8hyyr	3738	9	increase	increase	NN
cord-006860-a3b8hyyr	3738	10	of	of	IN
cord-006860-a3b8hyyr	3738	11	CD62P	cd62p	NN
cord-006860-a3b8hyyr	3738	12	on	on	IN
cord-006860-a3b8hyyr	3738	13	the	the	DT
cord-006860-a3b8hyyr	3738	14	platelet	platelet	NN
cord-006860-a3b8hyyr	3738	15	surface	surface	NN
cord-006860-a3b8hyyr	3738	16	of	of	IN
cord-006860-a3b8hyyr	3738	17	ca	ca	NNP
cord-006860-a3b8hyyr	3738	18	.	.	.
cord-006860-a3b8hyyr	3739	1	10	10	CD
cord-006860-a3b8hyyr	3739	2	%	%	NN
cord-006860-a3b8hyyr	3739	3	,	,	,
cord-006860-a3b8hyyr	3739	4	without	without	IN
cord-006860-a3b8hyyr	3739	5	any	any	DT
cord-006860-a3b8hyyr	3739	6	change	change	NN
cord-006860-a3b8hyyr	3739	7	in	in	IN
cord-006860-a3b8hyyr	3739	8	the	the	DT
cord-006860-a3b8hyyr	3739	9	mean	mean	JJ
cord-006860-a3b8hyyr	3739	10	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	3739	11	.	.	.
cord-006860-a3b8hyyr	3740	1	Under	under	IN
cord-006860-a3b8hyyr	3740	2	these	these	DT
cord-006860-a3b8hyyr	3740	3	conditions	condition	NNS
cord-006860-a3b8hyyr	3740	4	increased	increase	VBD
cord-006860-a3b8hyyr	3740	5	CDllb	CDllb	NNP
cord-006860-a3b8hyyr	3740	6	on	on	IN
cord-006860-a3b8hyyr	3740	7	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	3740	8	and	and	CC
cord-006860-a3b8hyyr	3740	9	monoeytes	monoeyte	NNS
cord-006860-a3b8hyyr	3740	10	could	could	MD
cord-006860-a3b8hyyr	3740	11	be	be	VB
cord-006860-a3b8hyyr	3740	12	detected	detect	VBN
cord-006860-a3b8hyyr	3740	13	.	.	.
cord-006860-a3b8hyyr	3741	1	An	an	DT
cord-006860-a3b8hyyr	3741	2	increase	increase	NN
cord-006860-a3b8hyyr	3741	3	in	in	IN
cord-006860-a3b8hyyr	3741	4	the	the	DT
cord-006860-a3b8hyyr	3741	5	rosette	rosette	NN
cord-006860-a3b8hyyr	3741	6	formation	formation	NN
cord-006860-a3b8hyyr	3741	7	could	could	MD
cord-006860-a3b8hyyr	3741	8	also	also	RB
cord-006860-a3b8hyyr	3741	9	be	be	VB
cord-006860-a3b8hyyr	3741	10	measured	measure	VBN
cord-006860-a3b8hyyr	3741	11	(	(	-LRB-
cord-006860-a3b8hyyr	3741	12	greater	great	JJR
cord-006860-a3b8hyyr	3741	13	index	index	NN
cord-006860-a3b8hyyr	3741	14	)	)	-RRB-
cord-006860-a3b8hyyr	3741	15	,	,	,
cord-006860-a3b8hyyr	3741	16	in	in	IN
cord-006860-a3b8hyyr	3741	17	that	that	IN
cord-006860-a3b8hyyr	3741	18	the	the	DT
cord-006860-a3b8hyyr	3741	19	percent	percent	NN
cord-006860-a3b8hyyr	3741	20	of	of	IN
cord-006860-a3b8hyyr	3741	21	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	3741	22	which	which	WDT
cord-006860-a3b8hyyr	3741	23	were	be	VBD
cord-006860-a3b8hyyr	3741	24	platelet	platelet	NN
cord-006860-a3b8hyyr	3741	25	-	-	HYPH
cord-006860-a3b8hyyr	3741	26	positive	positive	JJ
cord-006860-a3b8hyyr	3741	27	increased	increase	VBD
cord-006860-a3b8hyyr	3741	28	with	with	IN
cord-006860-a3b8hyyr	3741	29	no	no	DT
cord-006860-a3b8hyyr	3741	30	change	change	NN
cord-006860-a3b8hyyr	3741	31	in	in	IN
cord-006860-a3b8hyyr	3741	32	the	the	DT
cord-006860-a3b8hyyr	3741	33	mean	mean	JJ
cord-006860-a3b8hyyr	3741	34	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	3741	35	of	of	IN
cord-006860-a3b8hyyr	3741	36	the	the	DT
cord-006860-a3b8hyyr	3741	37	positive	positive	JJ
cord-006860-a3b8hyyr	3741	38	events	event	NNS
cord-006860-a3b8hyyr	3741	39	,	,	,
cord-006860-a3b8hyyr	3741	40	whereas	whereas	IN
cord-006860-a3b8hyyr	3741	41	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	3741	42	showed	show	VBD
cord-006860-a3b8hyyr	3741	43	an	an	DT
cord-006860-a3b8hyyr	3741	44	increased	increase	VBN
cord-006860-a3b8hyyr	3741	45	mean	mean	NN
cord-006860-a3b8hyyr	3741	46	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	3741	47	,	,	,
cord-006860-a3b8hyyr	3741	48	but	but	CC
cord-006860-a3b8hyyr	3741	49	not	not	RB
cord-006860-a3b8hyyr	3741	50	an	an	DT
cord-006860-a3b8hyyr	3741	51	increased	increase	VBN
cord-006860-a3b8hyyr	3741	52	number	number	NN
cord-006860-a3b8hyyr	3741	53	,	,	,
cord-006860-a3b8hyyr	3741	54	of	of	IN
cord-006860-a3b8hyyr	3741	55	platelet	platelet	NN
cord-006860-a3b8hyyr	3741	56	-	-	HYPH
cord-006860-a3b8hyyr	3741	57	positive	positive	JJ
cord-006860-a3b8hyyr	3741	58	events	event	NNS
cord-006860-a3b8hyyr	3741	59	.	.	.
cord-006860-a3b8hyyr	3742	1	The	the	DT
cord-006860-a3b8hyyr	3742	2	time	time	NN
cord-006860-a3b8hyyr	3742	3	-	-	HYPH
cord-006860-a3b8hyyr	3742	4	dependent	dependent	JJ
cord-006860-a3b8hyyr	3742	5	changes	change	NNS
cord-006860-a3b8hyyr	3742	6	in	in	IN
cord-006860-a3b8hyyr	3742	7	rosette	rosette	NN
cord-006860-a3b8hyyr	3742	8	formation	formation	NN
cord-006860-a3b8hyyr	3742	9	on	on	IN
cord-006860-a3b8hyyr	3742	10	stirring	stirring	NN
cord-006860-a3b8hyyr	3742	11	could	could	MD
cord-006860-a3b8hyyr	3742	12	be	be	VB
cord-006860-a3b8hyyr	3742	13	further	further	RB
cord-006860-a3b8hyyr	3742	14	increased	increase	VBN
cord-006860-a3b8hyyr	3742	15	by	by	IN
cord-006860-a3b8hyyr	3742	16	addition	addition	NN
cord-006860-a3b8hyyr	3742	17	of	of	IN
cord-006860-a3b8hyyr	3742	18	ADP	ADP	NNP
cord-006860-a3b8hyyr	3742	19	.	.	.
cord-006860-a3b8hyyr	3743	1	These	these	DT
cord-006860-a3b8hyyr	3743	2	results	result	NNS
cord-006860-a3b8hyyr	3743	3	show	show	VBP
cord-006860-a3b8hyyr	3743	4	that	that	IN
cord-006860-a3b8hyyr	3743	5	it	-PRON-	PRP
cord-006860-a3b8hyyr	3743	6	is	be	VBZ
cord-006860-a3b8hyyr	3743	7	possible	possible	JJ
cord-006860-a3b8hyyr	3743	8	to	to	TO
cord-006860-a3b8hyyr	3743	9	measure	measure	VB
cord-006860-a3b8hyyr	3743	10	rosette	rosette	NN
cord-006860-a3b8hyyr	3743	11	formation	formation	NN
cord-006860-a3b8hyyr	3743	12	,	,	,
cord-006860-a3b8hyyr	3743	13	and	and	CC
cord-006860-a3b8hyyr	3743	14	also	also	RB
cord-006860-a3b8hyyr	3743	15	the	the	DT
cord-006860-a3b8hyyr	3743	16	influence	influence	NN
cord-006860-a3b8hyyr	3743	17	of	of	IN
cord-006860-a3b8hyyr	3743	18	effector	effector	NN
cord-006860-a3b8hyyr	3743	19	agents	agent	NNS
cord-006860-a3b8hyyr	3743	20	(	(	-LRB-
cord-006860-a3b8hyyr	3743	21	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3743	22	or	or	CC
cord-006860-a3b8hyyr	3743	23	activators	activator	NNS
cord-006860-a3b8hyyr	3743	24	of	of	IN
cord-006860-a3b8hyyr	3743	25	platelets	platelet	NNS
cord-006860-a3b8hyyr	3743	26	or	or	CC
cord-006860-a3b8hyyr	3743	27	leukocytes	leukocyte	NNS
cord-006860-a3b8hyyr	3743	28	)	)	-RRB-
cord-006860-a3b8hyyr	3743	29	on	on	IN
cord-006860-a3b8hyyr	3743	30	rosette	rosette	NN
cord-006860-a3b8hyyr	3743	31	formation	formation	NN
cord-006860-a3b8hyyr	3743	32	,	,	,
cord-006860-a3b8hyyr	3743	33	in	in	IN
cord-006860-a3b8hyyr	3743	34	whole	whole	JJ
cord-006860-a3b8hyyr	3743	35	blood	blood	NN
cord-006860-a3b8hyyr	3743	36	using	use	VBG
cord-006860-a3b8hyyr	3743	37	flow	flow	NN
cord-006860-a3b8hyyr	3743	38	eytometry	eytometry	NN
cord-006860-a3b8hyyr	3743	39	.	.	.
cord-006860-a3b8hyyr	3744	1	17	17	CD
cord-006860-a3b8hyyr	3744	2	ITP	ITP	NNP
cord-006860-a3b8hyyr	3744	3	patients	patient	NNS
cord-006860-a3b8hyyr	3744	4	undergoing	undergo	VBG
cord-006860-a3b8hyyr	3744	5	splenectomy	splenectomy	NN
cord-006860-a3b8hyyr	3744	6	were	be	VBD
cord-006860-a3b8hyyr	3744	7	observed	observe	VBN
cord-006860-a3b8hyyr	3744	8	after	after	IN
cord-006860-a3b8hyyr	3744	9	1	1	CD
cord-006860-a3b8hyyr	3744	10	-	-	SYM
cord-006860-a3b8hyyr	3744	11	30	30	CD
cord-006860-a3b8hyyr	3744	12	years	year	NNS
cord-006860-a3b8hyyr	3744	13	following	follow	VBG
cord-006860-a3b8hyyr	3744	14	operation	operation	NN
cord-006860-a3b8hyyr	3744	15	and	and	CC
cord-006860-a3b8hyyr	3744	16	divided	divide	VBD
cord-006860-a3b8hyyr	3744	17	into	into	IN
cord-006860-a3b8hyyr	3744	18	2	2	CD
cord-006860-a3b8hyyr	3744	19	groups	group	NNS
cord-006860-a3b8hyyr	3744	20	.	.	.
cord-006860-a3b8hyyr	3745	1	First	first	JJ
cord-006860-a3b8hyyr	3745	2	group	group	NN
cord-006860-a3b8hyyr	3745	3	consisted	consist	VBD
cord-006860-a3b8hyyr	3745	4	of	of	IN
cord-006860-a3b8hyyr	3745	5	8	8	CD
cord-006860-a3b8hyyr	3745	6	patients	patient	NNS
cord-006860-a3b8hyyr	3745	7	with	with	IN
cord-006860-a3b8hyyr	3745	8	normal	normal	JJ
cord-006860-a3b8hyyr	3745	9	platelets	platelet	NNS
cord-006860-a3b8hyyr	3745	10	count	count	VBP
cord-006860-a3b8hyyr	3745	11	and	and	CC
cord-006860-a3b8hyyr	3745	12	absence	absence	NN
cord-006860-a3b8hyyr	3745	13	of	of	IN
cord-006860-a3b8hyyr	3745	14	haemorrhagic	haemorrhagic	JJ
cord-006860-a3b8hyyr	3745	15	syndrome	syndrome	NN
cord-006860-a3b8hyyr	3745	16	.	.	.
cord-006860-a3b8hyyr	3746	1	Second	second	JJ
cord-006860-a3b8hyyr	3746	2	group	group	NN
cord-006860-a3b8hyyr	3746	3	was	be	VBD
cord-006860-a3b8hyyr	3746	4	formed	form	VBN
cord-006860-a3b8hyyr	3746	5	of	of	IN
cord-006860-a3b8hyyr	3746	6	9	9	CD
cord-006860-a3b8hyyr	3746	7	ITP	ITP	NNP
cord-006860-a3b8hyyr	3746	8	-	-	HYPH
cord-006860-a3b8hyyr	3746	9	patienfs	patienfs	NNP
cord-006860-a3b8hyyr	3746	10	with	with	IN
cord-006860-a3b8hyyr	3746	11	episodes	episode	NNS
cord-006860-a3b8hyyr	3746	12	of	of	IN
cord-006860-a3b8hyyr	3746	13	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	3746	14	recovery	recovery	NN
cord-006860-a3b8hyyr	3746	15	following	follow	VBG
cord-006860-a3b8hyyr	3746	16	certain	certain	JJ
cord-006860-a3b8hyyr	3746	17	time	time	NN
cord-006860-a3b8hyyr	3746	18	period	period	NN
cord-006860-a3b8hyyr	3746	19	after	after	IN
cord-006860-a3b8hyyr	3746	20	splenectomy	splenectomy	NN
cord-006860-a3b8hyyr	3746	21	.	.	.
cord-006860-a3b8hyyr	3747	1	In	in	IN
cord-006860-a3b8hyyr	3747	2	the	the	DT
cord-006860-a3b8hyyr	3747	3	aim	aim	NN
cord-006860-a3b8hyyr	3747	4	to	to	TO
cord-006860-a3b8hyyr	3747	5	study	study	VB
cord-006860-a3b8hyyr	3747	6	the	the	DT
cord-006860-a3b8hyyr	3747	7	cellular	cellular	JJ
cord-006860-a3b8hyyr	3747	8	immunity	immunity	NN
cord-006860-a3b8hyyr	3747	9	there	there	EX
cord-006860-a3b8hyyr	3747	10	were	be	VBD
cord-006860-a3b8hyyr	3747	11	carried	carry	VBN
cord-006860-a3b8hyyr	3747	12	out	out	RP
cord-006860-a3b8hyyr	3747	13	immunophenotypical	immunophenotypical	JJ
cord-006860-a3b8hyyr	3747	14	investigations	investigation	NNS
cord-006860-a3b8hyyr	3747	15	of	of	IN
cord-006860-a3b8hyyr	3747	16	blood	blood	NN
cord-006860-a3b8hyyr	3747	17	samples	sample	NNS
cord-006860-a3b8hyyr	3747	18	using	use	VBG
cord-006860-a3b8hyyr	3747	19	immunofluorescence	immunofluorescence	NN
cord-006860-a3b8hyyr	3747	20	method	method	NN
cord-006860-a3b8hyyr	3747	21	with	with	IN
cord-006860-a3b8hyyr	3747	22	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	3747	23	antibodies	antibody	NNS
cord-006860-a3b8hyyr	3747	24	application	application	NN
cord-006860-a3b8hyyr	3747	25	.	.	.
cord-006860-a3b8hyyr	3748	1	The	the	DT
cord-006860-a3b8hyyr	3748	2	increase	increase	NN
cord-006860-a3b8hyyr	3748	3	of	of	IN
cord-006860-a3b8hyyr	3748	4	B	b	NN
cord-006860-a3b8hyyr	3748	5	-	-	HYPH
cord-006860-a3b8hyyr	3748	6	cells	cell	NNS
cord-006860-a3b8hyyr	3748	7	,	,	,
cord-006860-a3b8hyyr	3748	8	expressing	express	VBG
cord-006860-a3b8hyyr	3748	9	CD22	CD22	NNP
cord-006860-a3b8hyyr	3748	10	,	,	,
cord-006860-a3b8hyyr	3748	11	CD37	CD37	NNP
cord-006860-a3b8hyyr	3748	12	,	,	,
cord-006860-a3b8hyyr	3748	13	HLA	HLA	NNP
cord-006860-a3b8hyyr	3748	14	-	-	HYPH
cord-006860-a3b8hyyr	3748	15	Dr	Dr	NNP
cord-006860-a3b8hyyr	3748	16	-	-	HYPH
cord-006860-a3b8hyyr	3748	17	antigen	antigen	NNP
cord-006860-a3b8hyyr	3748	18	has	have	VBZ
cord-006860-a3b8hyyr	3748	19	been	be	VBN
cord-006860-a3b8hyyr	3748	20	revealed	reveal	VBN
cord-006860-a3b8hyyr	3748	21	in	in	IN
cord-006860-a3b8hyyr	3748	22	the	the	DT
cord-006860-a3b8hyyr	3748	23	2nd	2nd	JJ
cord-006860-a3b8hyyr	3748	24	group	group	NN
cord-006860-a3b8hyyr	3748	25	.	.	.
cord-006860-a3b8hyyr	3749	1	Quantity	quantity	NN
cord-006860-a3b8hyyr	3749	2	of	of	IN
cord-006860-a3b8hyyr	3749	3	SRFC	SRFC	NNP
cord-006860-a3b8hyyr	3749	4	,	,	,
cord-006860-a3b8hyyr	3749	5	CD3	CD3	NNP
cord-006860-a3b8hyyr	3749	6	+	+	CC
cord-006860-a3b8hyyr	3749	7	,	,	,
cord-006860-a3b8hyyr	3749	8	CD5	CD5	NNP
cord-006860-a3b8hyyr	3749	9	+	+	CC
cord-006860-a3b8hyyr	3749	10	cells	cell	NNS
cord-006860-a3b8hyyr	3749	11	in	in	IN
cord-006860-a3b8hyyr	3749	12	the	the	DT
cord-006860-a3b8hyyr	3749	13	blood	blood	NN
cord-006860-a3b8hyyr	3749	14	of	of	IN
cord-006860-a3b8hyyr	3749	15	recovered	recover	VBN
cord-006860-a3b8hyyr	3749	16	patients	patient	NNS
cord-006860-a3b8hyyr	3749	17	was	be	VBD
cord-006860-a3b8hyyr	3749	18	lower	low	JJR
cord-006860-a3b8hyyr	3749	19	than	than	IN
cord-006860-a3b8hyyr	3749	20	in	in	IN
cord-006860-a3b8hyyr	3749	21	patients	patient	NNS
cord-006860-a3b8hyyr	3749	22	of	of	IN
cord-006860-a3b8hyyr	3749	23	the	the	DT
cord-006860-a3b8hyyr	3749	24	first	first	JJ
cord-006860-a3b8hyyr	3749	25	group	group	NN
cord-006860-a3b8hyyr	3749	26	.	.	.
cord-006860-a3b8hyyr	3750	1	This	this	DT
cord-006860-a3b8hyyr	3750	2	group	group	NN
cord-006860-a3b8hyyr	3750	3	was	be	VBD
cord-006860-a3b8hyyr	3750	4	also	also	RB
cord-006860-a3b8hyyr	3750	5	characterized	characterize	VBN
cord-006860-a3b8hyyr	3750	6	by	by	IN
cord-006860-a3b8hyyr	3750	7	statistically	statistically	RB
cord-006860-a3b8hyyr	3750	8	significantly	significantly	RB
cord-006860-a3b8hyyr	3750	9	increased	increase	VBN
cord-006860-a3b8hyyr	3750	10	level	level	NN
cord-006860-a3b8hyyr	3750	11	of	of	IN
cord-006860-a3b8hyyr	3750	12	CD4	CD4	NNP
cord-006860-a3b8hyyr	3750	13	+	+	CC
cord-006860-a3b8hyyr	3750	14	cells	cell	NNS
cord-006860-a3b8hyyr	3750	15	while	while	IN
cord-006860-a3b8hyyr	3750	16	the	the	DT
cord-006860-a3b8hyyr	3750	17	CD4	CD4	NNP
cord-006860-a3b8hyyr	3750	18	/	/	SYM
cord-006860-a3b8hyyr	3750	19	CD8	CD8	NNP
cord-006860-a3b8hyyr	3750	20	ratio	ratio	NN
cord-006860-a3b8hyyr	3750	21	was	be	VBD
cord-006860-a3b8hyyr	3750	22	equal	equal	JJ
cord-006860-a3b8hyyr	3750	23	to	to	IN
cord-006860-a3b8hyyr	3750	24	1.0	1.0	CD
cord-006860-a3b8hyyr	3750	25	:	:	:
cord-006860-a3b8hyyr	3750	26	i	i	PRP
cord-006860-a3b8hyyr	3750	27	:	:	:
cord-006860-a3b8hyyr	3750	28	0.3	0.3	CD
cord-006860-a3b8hyyr	3750	29	%	%	NN
cord-006860-a3b8hyyr	3750	30	(	(	-LRB-
cord-006860-a3b8hyyr	3750	31	0,5	0,5	CD
cord-006860-a3b8hyyr	3750	32	+	+	SYM
cord-006860-a3b8hyyr	3750	33	0,1	0,1	CD
cord-006860-a3b8hyyr	3750	34	%	%	NN
cord-006860-a3b8hyyr	3750	35	in	in	IN
cord-006860-a3b8hyyr	3750	36	patients	patient	NNS
cord-006860-a3b8hyyr	3750	37	of	of	IN
cord-006860-a3b8hyyr	3750	38	the	the	DT
cord-006860-a3b8hyyr	3750	39	second	second	JJ
cord-006860-a3b8hyyr	3750	40	group	group	NN
cord-006860-a3b8hyyr	3750	41	,	,	,
cord-006860-a3b8hyyr	3750	42	respectively	respectively	RB
cord-006860-a3b8hyyr	3750	43	,	,	,
cord-006860-a3b8hyyr	3750	44	p	p	NN
cord-006860-a3b8hyyr	3750	45	>	>	XX
cord-006860-a3b8hyyr	3750	46	O,05	o,05	NN
cord-006860-a3b8hyyr	3750	47	}	}	-RRB-
cord-006860-a3b8hyyr	3750	48	.	.	.
cord-006860-a3b8hyyr	3751	1	Also	also	RB
cord-006860-a3b8hyyr	3751	2	the	the	DT
cord-006860-a3b8hyyr	3751	3	relatively	relatively	RB
cord-006860-a3b8hyyr	3751	4	high	high	JJ
cord-006860-a3b8hyyr	3751	5	expression	expression	NN
cord-006860-a3b8hyyr	3751	6	of	of	IN
cord-006860-a3b8hyyr	3751	7	activating	activate	VBG
cord-006860-a3b8hyyr	3751	8	antigens	antigen	NNS
cord-006860-a3b8hyyr	3751	9	in	in	IN
cord-006860-a3b8hyyr	3751	10	patients	patient	NNS
cord-006860-a3b8hyyr	3751	11	with	with	IN
cord-006860-a3b8hyyr	3751	12	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	3751	13	recovery	recovery	NN
cord-006860-a3b8hyyr	3751	14	after	after	IN
cord-006860-a3b8hyyr	3751	15	splenectomy	splenectomy	NN
cord-006860-a3b8hyyr	3751	16	was	be	VBD
cord-006860-a3b8hyyr	3751	17	stated	state	VBN
cord-006860-a3b8hyyr	3751	18	.	.	.
cord-006860-a3b8hyyr	3752	1	Among	among	IN
cord-006860-a3b8hyyr	3752	2	infectious	infectious	JJ
cord-006860-a3b8hyyr	3752	3	complications	complication	NNS
cord-006860-a3b8hyyr	3752	4	in	in	IN
cord-006860-a3b8hyyr	3752	5	all	all	DT
cord-006860-a3b8hyyr	3752	6	patients	patient	NNS
cord-006860-a3b8hyyr	3752	7	observed	observe	VBN
cord-006860-a3b8hyyr	3752	8	were	be	VBD
cord-006860-a3b8hyyr	3752	9	predominantly	predominantly	RB
cord-006860-a3b8hyyr	3752	10	found	find	VBN
cord-006860-a3b8hyyr	3752	11	various	various	JJ
cord-006860-a3b8hyyr	3752	12	types	type	NNS
cord-006860-a3b8hyyr	3752	13	of	of	IN
cord-006860-a3b8hyyr	3752	14	throat	throat	NN
cord-006860-a3b8hyyr	3752	15	infection	infection	NN
cord-006860-a3b8hyyr	3752	16	,	,	,
cord-006860-a3b8hyyr	3752	17	mainly	mainly	RB
cord-006860-a3b8hyyr	3752	18	with	with	IN
cord-006860-a3b8hyyr	3752	19	unsatisfactory	unsatisfactory	JJ
cord-006860-a3b8hyyr	3752	20	treatment	treatment	NN
cord-006860-a3b8hyyr	3752	21	possibilities	possibility	NNS
cord-006860-a3b8hyyr	3752	22	.	.	.
cord-006860-a3b8hyyr	3753	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3753	2	have	have	VBP
cord-006860-a3b8hyyr	3753	3	observed	observe	VBN
cord-006860-a3b8hyyr	3753	4	the	the	DT
cord-006860-a3b8hyyr	3753	5	OPSI	OPSI	NNP
cord-006860-a3b8hyyr	3753	6	-	-	HYPH
cord-006860-a3b8hyyr	3753	7	syndrome	syndrome	NN
cord-006860-a3b8hyyr	3753	8	in	in	IN
cord-006860-a3b8hyyr	3753	9	2	2	CD
cord-006860-a3b8hyyr	3753	10	patients	patient	NNS
cord-006860-a3b8hyyr	3753	11	,	,	,
cord-006860-a3b8hyyr	3753	12	being	be	VBG
cord-006860-a3b8hyyr	3753	13	featured	feature	VBN
cord-006860-a3b8hyyr	3753	14	with	with	IN
cord-006860-a3b8hyyr	3753	15	marked	marked	JJ
cord-006860-a3b8hyyr	3753	16	tiredness	tiredness	NN
cord-006860-a3b8hyyr	3753	17	,	,	,
cord-006860-a3b8hyyr	3753	18	breath	breath	NN
cord-006860-a3b8hyyr	3753	19	loss	loss	NN
cord-006860-a3b8hyyr	3753	20	,	,	,
cord-006860-a3b8hyyr	3753	21	intolerance	intolerance	NN
cord-006860-a3b8hyyr	3753	22	of	of	IN
cord-006860-a3b8hyyr	3753	23	hard	hard	JJ
cord-006860-a3b8hyyr	3753	24	physical	physical	JJ
cord-006860-a3b8hyyr	3753	25	working	working	NN
cord-006860-a3b8hyyr	3753	26	,	,	,
cord-006860-a3b8hyyr	3753	27	diminished	diminished	JJ
cord-006860-a3b8hyyr	3753	28	ability	ability	NN
cord-006860-a3b8hyyr	3753	29	to	to	TO
cord-006860-a3b8hyyr	3753	30	maintain	maintain	VB
cord-006860-a3b8hyyr	3753	31	physical	physical	JJ
cord-006860-a3b8hyyr	3753	32	activity	activity	NN
cord-006860-a3b8hyyr	3753	33	.	.	.
cord-006860-a3b8hyyr	3754	1	Extracellular	Extracellular	NNP
cord-006860-a3b8hyyr	3754	2	matrix	matrix	NN
cord-006860-a3b8hyyr	3754	3	(	(	-LRB-
cord-006860-a3b8hyyr	3754	4	ECM	ECM	NNP
cord-006860-a3b8hyyr	3754	5	)	)	-RRB-
cord-006860-a3b8hyyr	3754	6	produced	produce	VBN
cord-006860-a3b8hyyr	3754	7	by	by	IN
cord-006860-a3b8hyyr	3754	8	human	human	JJ
cord-006860-a3b8hyyr	3754	9	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	3754	10	cells	cell	NNS
cord-006860-a3b8hyyr	3754	11	closely	closely	RB
cord-006860-a3b8hyyr	3754	12	resembles	resemble	VBZ
cord-006860-a3b8hyyr	3754	13	the	the	DT
cord-006860-a3b8hyyr	3754	14	vascular	vascular	JJ
cord-006860-a3b8hyyr	3754	15	subendothellal	subendothellal	NN
cord-006860-a3b8hyyr	3754	16	basal	basal	NN
cord-006860-a3b8hyyr	3754	17	lamina	lamina	NN
cord-006860-a3b8hyyr	3754	18	in	in	IN
cord-006860-a3b8hyyr	3754	19	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3754	20	organization	organization	NN
cord-006860-a3b8hyyr	3754	21	and	and	CC
cord-006860-a3b8hyyr	3754	22	chemical	chemical	NN
cord-006860-a3b8hyyr	3754	23	composition	composition	NN
cord-006860-a3b8hyyr	3754	24	.	.	.
cord-006860-a3b8hyyr	3755	1	Thus	thus	RB
cord-006860-a3b8hyyr	3755	2	it	-PRON-	PRP
cord-006860-a3b8hyyr	3755	3	contains	contain	VBZ
cord-006860-a3b8hyyr	3755	4	collagens	collagen	NNS
cord-006860-a3b8hyyr	3755	5	,	,	,
cord-006860-a3b8hyyr	3755	6	fibroneetin	fibroneetin	NNP
cord-006860-a3b8hyyr	3755	7	,	,	,
cord-006860-a3b8hyyr	3755	8	von	von	NNP
cord-006860-a3b8hyyr	3755	9	Witlebrand	Witlebrand	NNP
cord-006860-a3b8hyyr	3755	10	factor	factor	NN
cord-006860-a3b8hyyr	3755	11	,	,	,
cord-006860-a3b8hyyr	3755	12	thrombospondin	thrombospondin	NN
cord-006860-a3b8hyyr	3755	13	,	,	,
cord-006860-a3b8hyyr	3755	14	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3755	15	,	,	,
cord-006860-a3b8hyyr	3755	16	vitronectin	vitronectin	NNP
cord-006860-a3b8hyyr	3755	17	,	,	,
cord-006860-a3b8hyyr	3755	18	laminin	laminin	NN
cord-006860-a3b8hyyr	3755	19	and	and	CC
cord-006860-a3b8hyyr	3755	20	heparin	heparin	NN
cord-006860-a3b8hyyr	3755	21	-	-	HYPH
cord-006860-a3b8hyyr	3755	22	sulphate	sulphate	NN
cord-006860-a3b8hyyr	3755	23	.	.	.
cord-006860-a3b8hyyr	3756	1	Platelets	platelet	NNS
cord-006860-a3b8hyyr	3756	2	carry	carry	VBP
cord-006860-a3b8hyyr	3756	3	different	different	JJ
cord-006860-a3b8hyyr	3756	4	receptors	receptor	NNS
cord-006860-a3b8hyyr	3756	5	on	on	IN
cord-006860-a3b8hyyr	3756	6	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3756	7	membrane	membrane	NN
cord-006860-a3b8hyyr	3756	8	surface	surface	NN
cord-006860-a3b8hyyr	3756	9	with	with	IN
cord-006860-a3b8hyyr	3756	10	specific	specific	JJ
cord-006860-a3b8hyyr	3756	11	binding	bind	VBG
cord-006860-a3b8hyyr	3756	12	capacities	capacity	NNS
cord-006860-a3b8hyyr	3756	13	for	for	IN
cord-006860-a3b8hyyr	3756	14	one	one	CD
cord-006860-a3b8hyyr	3756	15	or	or	CC
cord-006860-a3b8hyyr	3756	16	more	more	JJR
cord-006860-a3b8hyyr	3756	17	of	of	IN
cord-006860-a3b8hyyr	3756	18	these	these	DT
cord-006860-a3b8hyyr	3756	19	extracellular	extracellular	JJ
cord-006860-a3b8hyyr	3756	20	matrix	matrix	NN
cord-006860-a3b8hyyr	3756	21	proteins	protein	NNS
cord-006860-a3b8hyyr	3756	22	,	,	,
cord-006860-a3b8hyyr	3756	23	such	such	JJ
cord-006860-a3b8hyyr	3756	24	as	as	IN
cord-006860-a3b8hyyr	3756	25	glycoprotein	glycoprotein	NN
cord-006860-a3b8hyyr	3756	26	(	(	-LRB-
cord-006860-a3b8hyyr	3756	27	GP	GP	NNP
cord-006860-a3b8hyyr	3756	28	)	)	-RRB-
cord-006860-a3b8hyyr	3756	29	IIbIIIa	IIbIIIa	NNP
cord-006860-a3b8hyyr	3756	30	,	,	,
cord-006860-a3b8hyyr	3756	31	GP	GP	NNP
cord-006860-a3b8hyyr	3756	32	Ib	Ib	NNP
cord-006860-a3b8hyyr	3756	33	/	/	SYM
cord-006860-a3b8hyyr	3756	34	IX	IX	NNP
cord-006860-a3b8hyyr	3756	35	and	and	CC
cord-006860-a3b8hyyr	3756	36	GPIIIb	GPIIIb	NNS
cord-006860-a3b8hyyr	3756	37	.	.	.
cord-006860-a3b8hyyr	3757	1	Incubation	incubation	NN
cord-006860-a3b8hyyr	3757	2	of	of	IN
cord-006860-a3b8hyyr	3757	3	platelets	platelet	NNS
cord-006860-a3b8hyyr	3757	4	with	with	IN
cord-006860-a3b8hyyr	3757	5	ECM	ECM	NNP
cord-006860-a3b8hyyr	3757	6	results	result	NNS
cord-006860-a3b8hyyr	3757	7	in	in	IN
cord-006860-a3b8hyyr	3757	8	platelet	platelet	NN
cord-006860-a3b8hyyr	3757	9	adhesion	adhesion	NN
cord-006860-a3b8hyyr	3757	10	,	,	,
cord-006860-a3b8hyyr	3757	11	degranulation	degranulation	NN
cord-006860-a3b8hyyr	3757	12	,	,	,
cord-006860-a3b8hyyr	3757	13	prostaglandin	prostaglandin	NN
cord-006860-a3b8hyyr	3757	14	synthesis	synthesis	NN
cord-006860-a3b8hyyr	3757	15	and	and	CC
cord-006860-a3b8hyyr	3757	16	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3757	17	.	.	.
cord-006860-a3b8hyyr	3758	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3758	2	studied	study	VBD
cord-006860-a3b8hyyr	3758	3	patients	patient	NNS
cord-006860-a3b8hyyr	3758	4	whose	whose	WP$
cord-006860-a3b8hyyr	3758	5	platelets	platelet	NNS
cord-006860-a3b8hyyr	3758	6	showed	show	VBD
cord-006860-a3b8hyyr	3758	7	either	either	CC
cord-006860-a3b8hyyr	3758	8	a	a	DT
cord-006860-a3b8hyyr	3758	9	receptor	receptor	NN
cord-006860-a3b8hyyr	3758	10	defect	defect	NN
cord-006860-a3b8hyyr	3758	11	in	in	IN
cord-006860-a3b8hyyr	3758	12	GPIIbIIIa	GPIIbIIIa	NNP
cord-006860-a3b8hyyr	3758	13	or	or	CC
cord-006860-a3b8hyyr	3758	14	GPIIIb	GPIIIb	NNS
cord-006860-a3b8hyyr	3758	15	or	or	CC
cord-006860-a3b8hyyr	3758	16	a	a	DT
cord-006860-a3b8hyyr	3758	17	storage	storage	NN
cord-006860-a3b8hyyr	3758	18	pool	pool	NN
cord-006860-a3b8hyyr	3758	19	disease	disease	NN
cord-006860-a3b8hyyr	3758	20	.	.	.
cord-006860-a3b8hyyr	3759	1	Adhesion	adhesion	NN
cord-006860-a3b8hyyr	3759	2	experiments	experiment	NNS
cord-006860-a3b8hyyr	3759	3	were	be	VBD
cord-006860-a3b8hyyr	3759	4	performed	perform	VBN
cord-006860-a3b8hyyr	3759	5	using	use	VBG
cord-006860-a3b8hyyr	3759	6	siliconised	siliconised	JJ
cord-006860-a3b8hyyr	3759	7	glass	glass	NN
cord-006860-a3b8hyyr	3759	8	,	,	,
cord-006860-a3b8hyyr	3759	9	collagen	collagen	NN
cord-006860-a3b8hyyr	3759	10	coated	coated	JJ
cord-006860-a3b8hyyr	3759	11	surfaces	surface	NNS
cord-006860-a3b8hyyr	3759	12	,	,	,
cord-006860-a3b8hyyr	3759	13	immobilized	immobilize	VBN
cord-006860-a3b8hyyr	3759	14	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3759	15	as	as	RB
cord-006860-a3b8hyyr	3759	16	well	well	RB
cord-006860-a3b8hyyr	3759	17	as	as	IN
cord-006860-a3b8hyyr	3759	18	human	human	JJ
cord-006860-a3b8hyyr	3759	19	subendothelial	subendothelial	NNP
cord-006860-a3b8hyyr	3759	20	matrix	matrix	NN
cord-006860-a3b8hyyr	3759	21	.	.	.
cord-006860-a3b8hyyr	3760	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	3760	2	adhesion	adhesion	NN
cord-006860-a3b8hyyr	3760	3	of	of	IN
cord-006860-a3b8hyyr	3760	4	patients	patient	NNS
cord-006860-a3b8hyyr	3760	5	with	with	IN
cord-006860-a3b8hyyr	3760	6	Thrombasthenia	Thrombasthenia	NNP
cord-006860-a3b8hyyr	3760	7	Glanzmann	Glanzmann	NNP
cord-006860-a3b8hyyr	3760	8	(	(	-LRB-
cord-006860-a3b8hyyr	3760	9	receptor	receptor	NN
cord-006860-a3b8hyyr	3760	10	defect	defect	NN
cord-006860-a3b8hyyr	3760	11	of	of	IN
cord-006860-a3b8hyyr	3760	12	GPIIbIIIa	GPIIbIIIa	NNP
cord-006860-a3b8hyyr	3760	13	)	)	-RRB-
cord-006860-a3b8hyyr	3760	14	resulted	result	VBD
cord-006860-a3b8hyyr	3760	15	in	in	IN
cord-006860-a3b8hyyr	3760	16	a	a	DT
cord-006860-a3b8hyyr	3760	17	total	total	JJ
cord-006860-a3b8hyyr	3760	18	lack	lack	NN
cord-006860-a3b8hyyr	3760	19	of	of	IN
cord-006860-a3b8hyyr	3760	20	binding	bind	VBG
cord-006860-a3b8hyyr	3760	21	to	to	IN
cord-006860-a3b8hyyr	3760	22	silieonised	silieonise	VBN
cord-006860-a3b8hyyr	3760	23	glass	glass	NN
cord-006860-a3b8hyyr	3760	24	and	and	CC
cord-006860-a3b8hyyr	3760	25	immobilized	immobilize	VBN
cord-006860-a3b8hyyr	3760	26	fibfinogen	fibfinogen	NN
cord-006860-a3b8hyyr	3760	27	.	.	.
cord-006860-a3b8hyyr	3761	1	Adhesion	adhesion	NN
cord-006860-a3b8hyyr	3761	2	to	to	IN
cord-006860-a3b8hyyr	3761	3	collagen	collagen	NN
cord-006860-a3b8hyyr	3761	4	was	be	VBD
cord-006860-a3b8hyyr	3761	5	almost	almost	RB
cord-006860-a3b8hyyr	3761	6	normal	normal	JJ
cord-006860-a3b8hyyr	3761	7	in	in	IN
cord-006860-a3b8hyyr	3761	8	spite	spite	NN
cord-006860-a3b8hyyr	3761	9	of	of	IN
cord-006860-a3b8hyyr	3761	10	the	the	DT
cord-006860-a3b8hyyr	3761	11	fact	fact	NN
cord-006860-a3b8hyyr	3761	12	that	that	IN
cord-006860-a3b8hyyr	3761	13	only	only	JJ
cord-006860-a3b8hyyr	3761	14	single	single	JJ
cord-006860-a3b8hyyr	3761	15	platelets	platelet	NNS
cord-006860-a3b8hyyr	3761	16	sticked	stick	VBN
cord-006860-a3b8hyyr	3761	17	to	to	IN
cord-006860-a3b8hyyr	3761	18	the	the	DT
cord-006860-a3b8hyyr	3761	19	surface	surface	NN
cord-006860-a3b8hyyr	3761	20	and	and	CC
cord-006860-a3b8hyyr	3761	21	no	no	DT
cord-006860-a3b8hyyr	3761	22	microaggregates	microaggregate	NNS
cord-006860-a3b8hyyr	3761	23	were	be	VBD
cord-006860-a3b8hyyr	3761	24	observed	observe	VBN
cord-006860-a3b8hyyr	3761	25	.	.	.
cord-006860-a3b8hyyr	3762	1	The	the	DT
cord-006860-a3b8hyyr	3762	2	adhesion	adhesion	NN
cord-006860-a3b8hyyr	3762	3	to	to	IN
cord-006860-a3b8hyyr	3762	4	ECM	ECM	NNP
cord-006860-a3b8hyyr	3762	5	was	be	VBD
cord-006860-a3b8hyyr	3762	6	diminished	diminish	VBN
cord-006860-a3b8hyyr	3762	7	and	and	CC
cord-006860-a3b8hyyr	3762	8	also	also	RB
cord-006860-a3b8hyyr	3762	9	no	no	DT
cord-006860-a3b8hyyr	3762	10	aggregates	aggregate	NNS
cord-006860-a3b8hyyr	3762	11	were	be	VBD
cord-006860-a3b8hyyr	3762	12	detected	detect	VBN
cord-006860-a3b8hyyr	3762	13	.	.	.
cord-006860-a3b8hyyr	3763	1	Patients	patient	NNS
cord-006860-a3b8hyyr	3763	2	with	with	IN
cord-006860-a3b8hyyr	3763	3	a	a	DT
cord-006860-a3b8hyyr	3763	4	receptor	receptor	NN
cord-006860-a3b8hyyr	3763	5	defect	defect	NN
cord-006860-a3b8hyyr	3763	6	in	in	IN
cord-006860-a3b8hyyr	3763	7	GPIIIb	GPIIIb	NNS
cord-006860-a3b8hyyr	3763	8	showed	show	VBD
cord-006860-a3b8hyyr	3763	9	normal	normal	JJ
cord-006860-a3b8hyyr	3763	10	platelet	platelet	NN
cord-006860-a3b8hyyr	3763	11	adhesion	adhesion	NN
cord-006860-a3b8hyyr	3763	12	to	to	IN
cord-006860-a3b8hyyr	3763	13	siliconised	siliconised	JJ
cord-006860-a3b8hyyr	3763	14	glass	glass	NN
cord-006860-a3b8hyyr	3763	15	and	and	CC
cord-006860-a3b8hyyr	3763	16	immobilized	immobilize	VBN
cord-006860-a3b8hyyr	3763	17	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3763	18	but	but	CC
cord-006860-a3b8hyyr	3763	19	binding	bind	VBG
cord-006860-a3b8hyyr	3763	20	to	to	IN
cord-006860-a3b8hyyr	3763	21	collagen	collagen	NN
cord-006860-a3b8hyyr	3763	22	and	and	CC
cord-006860-a3b8hyyr	3763	23	ECM	ECM	NNP
cord-006860-a3b8hyyr	3763	24	was	be	VBD
cord-006860-a3b8hyyr	3763	25	markedly	markedly	RB
cord-006860-a3b8hyyr	3763	26	reduced	reduce	VBN
cord-006860-a3b8hyyr	3763	27	,	,	,
cord-006860-a3b8hyyr	3763	28	while	while	IN
cord-006860-a3b8hyyr	3763	29	platelets	platelet	NNS
cord-006860-a3b8hyyr	3763	30	with	with	IN
cord-006860-a3b8hyyr	3763	31	a	a	DT
cord-006860-a3b8hyyr	3763	32	storage	storage	NN
cord-006860-a3b8hyyr	3763	33	pool	pool	NN
cord-006860-a3b8hyyr	3763	34	defect	defect	NN
cord-006860-a3b8hyyr	3763	35	sticked	stick	VBN
cord-006860-a3b8hyyr	3763	36	to	to	IN
cord-006860-a3b8hyyr	3763	37	siliconised	siliconised	JJ
cord-006860-a3b8hyyr	3763	38	glass	glass	NN
cord-006860-a3b8hyyr	3763	39	but	but	CC
cord-006860-a3b8hyyr	3763	40	failed	fail	VBD
cord-006860-a3b8hyyr	3763	41	to	to	TO
cord-006860-a3b8hyyr	3763	42	adhere	adhere	VB
cord-006860-a3b8hyyr	3763	43	to	to	IN
cord-006860-a3b8hyyr	3763	44	ECM	ECM	NNP
cord-006860-a3b8hyyr	3763	45	.	.	.
cord-006860-a3b8hyyr	3764	1	By	by	IN
cord-006860-a3b8hyyr	3764	2	centrifugation	centrifugation	NN
cord-006860-a3b8hyyr	3764	3	of	of	IN
cord-006860-a3b8hyyr	3764	4	citrate	citrate	NN
cord-006860-a3b8hyyr	3764	5	blood	blood	NN
cord-006860-a3b8hyyr	3764	6	(	(	-LRB-
cord-006860-a3b8hyyr	3764	7	250	250	CD
cord-006860-a3b8hyyr	3764	8	x	x	SYM
cord-006860-a3b8hyyr	3764	9	g	g	NN
cord-006860-a3b8hyyr	3764	10	,	,	,
cord-006860-a3b8hyyr	3764	11	10	10	CD
cord-006860-a3b8hyyr	3764	12	min	min	NN
cord-006860-a3b8hyyr	3764	13	)	)	-RRB-
cord-006860-a3b8hyyr	3764	14	erythrocytes	erythrocyte	NNS
cord-006860-a3b8hyyr	3764	15	and	and	CC
cord-006860-a3b8hyyr	3764	16	leucocytes	leucocyte	NNS
cord-006860-a3b8hyyr	3764	17	go	go	VBP
cord-006860-a3b8hyyr	3764	18	to	to	IN
cord-006860-a3b8hyyr	3764	19	the	the	DT
cord-006860-a3b8hyyr	3764	20	bottom	bottom	NN
cord-006860-a3b8hyyr	3764	21	,	,	,
cord-006860-a3b8hyyr	3764	22	whereas	whereas	IN
cord-006860-a3b8hyyr	3764	23	plasma	plasma	NN
cord-006860-a3b8hyyr	3764	24	and	and	CC
cord-006860-a3b8hyyr	3764	25	thrombocytes	thrombocyte	NNS
cord-006860-a3b8hyyr	3764	26	stream	stream	VBP
cord-006860-a3b8hyyr	3764	27	in	in	IN
cord-006860-a3b8hyyr	3764	28	the	the	DT
cord-006860-a3b8hyyr	3764	29	upper	upper	JJ
cord-006860-a3b8hyyr	3764	30	part	part	NN
cord-006860-a3b8hyyr	3764	31	of	of	IN
cord-006860-a3b8hyyr	3764	32	the	the	DT
cord-006860-a3b8hyyr	3764	33	probe	probe	NN
cord-006860-a3b8hyyr	3764	34	.	.	.
cord-006860-a3b8hyyr	3765	1	So	so	RB
cord-006860-a3b8hyyr	3765	2	the	the	DT
cord-006860-a3b8hyyr	3765	3	thrombocyte	thrombocyte	NNP
cord-006860-a3b8hyyr	3765	4	count	count	VBP
cord-006860-a3b8hyyr	3765	5	doubbles	doubble	NNS
cord-006860-a3b8hyyr	3765	6	in	in	IN
cord-006860-a3b8hyyr	3765	7	the	the	DT
cord-006860-a3b8hyyr	3765	8	platelet	platelet	NN
cord-006860-a3b8hyyr	3765	9	rich	rich	JJ
cord-006860-a3b8hyyr	3765	10	plasma	plasma	NN
cord-006860-a3b8hyyr	3765	11	in	in	IN
cord-006860-a3b8hyyr	3765	12	contrast	contrast	NN
cord-006860-a3b8hyyr	3765	13	to	to	IN
cord-006860-a3b8hyyr	3765	14	the	the	DT
cord-006860-a3b8hyyr	3765	15	platelet	platelet	NN
cord-006860-a3b8hyyr	3765	16	count	count	NN
cord-006860-a3b8hyyr	3765	17	in	in	IN
cord-006860-a3b8hyyr	3765	18	the	the	DT
cord-006860-a3b8hyyr	3765	19	whole	whole	JJ
cord-006860-a3b8hyyr	3765	20	blood	blood	NN
cord-006860-a3b8hyyr	3765	21	volume	volume	NN
cord-006860-a3b8hyyr	3765	22	.	.	.
cord-006860-a3b8hyyr	3766	1	If	if	IN
cord-006860-a3b8hyyr	3766	2	the	the	DT
cord-006860-a3b8hyyr	3766	3	thrombocytes	thrombocyte	NNS
cord-006860-a3b8hyyr	3766	4	are	be	VBP
cord-006860-a3b8hyyr	3766	5	more	more	RBR
cord-006860-a3b8hyyr	3766	6	or	or	CC
cord-006860-a3b8hyyr	3766	7	less	less	RBR
cord-006860-a3b8hyyr	3766	8	activated	activate	VBN
cord-006860-a3b8hyyr	3766	9	,	,	,
cord-006860-a3b8hyyr	3766	10	they	-PRON-	PRP
cord-006860-a3b8hyyr	3766	11	adhaere	adhaere	RB
cord-006860-a3b8hyyr	3766	12	on	on	IN
cord-006860-a3b8hyyr	3766	13	erythrocytes	erythrocyte	NNS
cord-006860-a3b8hyyr	3766	14	,	,	,
cord-006860-a3b8hyyr	3766	15	leucocytes	leucocyte	NNS
cord-006860-a3b8hyyr	3766	16	or	or	CC
cord-006860-a3b8hyyr	3766	17	aggregate	aggregate	JJ
cord-006860-a3b8hyyr	3766	18	end	end	NN
cord-006860-a3b8hyyr	3766	19	are	be	VBP
cord-006860-a3b8hyyr	3766	20	not	not	RB
cord-006860-a3b8hyyr	3766	21	able	able	JJ
cord-006860-a3b8hyyr	3766	22	to	to	TO
cord-006860-a3b8hyyr	3766	23	stream	stream	VB
cord-006860-a3b8hyyr	3766	24	upwards	upwards	RB
cord-006860-a3b8hyyr	3766	25	.	.	.
cord-006860-a3b8hyyr	3767	1	The	the	DT
cord-006860-a3b8hyyr	3767	2	quotient	quotient	NN
cord-006860-a3b8hyyr	3767	3	between	between	IN
cord-006860-a3b8hyyr	3767	4	thrombocyte	thrombocyte	NN
cord-006860-a3b8hyyr	3767	5	counts	count	NNS
cord-006860-a3b8hyyr	3767	6	in	in	IN
cord-006860-a3b8hyyr	3767	7	PRP	prp	NN
cord-006860-a3b8hyyr	3767	8	and	and	CC
cord-006860-a3b8hyyr	3767	9	whole	whole	JJ
cord-006860-a3b8hyyr	3767	10	blood	blood	NN
cord-006860-a3b8hyyr	3767	11	is	be	VBZ
cord-006860-a3b8hyyr	3767	12	a	a	DT
cord-006860-a3b8hyyr	3767	13	measure	measure	NN
cord-006860-a3b8hyyr	3767	14	for	for	IN
cord-006860-a3b8hyyr	3767	15	thrombocyte	thrombocyte	NNP
cord-006860-a3b8hyyr	3767	16	activation	activation	NN
cord-006860-a3b8hyyr	3767	17	.	.	.
cord-006860-a3b8hyyr	3768	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3768	2	chequed	cheque	VBD
cord-006860-a3b8hyyr	3768	3	the	the	DT
cord-006860-a3b8hyyr	3768	4	value	value	NN
cord-006860-a3b8hyyr	3768	5	of	of	IN
cord-006860-a3b8hyyr	3768	6	this	this	DT
cord-006860-a3b8hyyr	3768	7	screening	screening	NN
cord-006860-a3b8hyyr	3768	8	in	in	IN
cord-006860-a3b8hyyr	3768	9	different	different	JJ
cord-006860-a3b8hyyr	3768	10	groups	group	NNS
cord-006860-a3b8hyyr	3768	11	of	of	IN
cord-006860-a3b8hyyr	3768	12	patients	patient	NNS
cord-006860-a3b8hyyr	3768	13	with	with	IN
cord-006860-a3b8hyyr	3768	14	arterial	arterial	JJ
cord-006860-a3b8hyyr	3768	15	occlusions	occlusion	NNS
cord-006860-a3b8hyyr	3768	16	disease	disease	NN
cord-006860-a3b8hyyr	3768	17	(	(	-LRB-
cord-006860-a3b8hyyr	3768	18	AOD	AOD	NNP
cord-006860-a3b8hyyr	3768	19	)	)	-RRB-
cord-006860-a3b8hyyr	3768	20	,	,	,
cord-006860-a3b8hyyr	3768	21	chronical	chronical	JJ
cord-006860-a3b8hyyr	3768	22	venous	venous	JJ
cord-006860-a3b8hyyr	3768	23	disease	disease	NN
cord-006860-a3b8hyyr	3768	24	(	(	-LRB-
cord-006860-a3b8hyyr	3768	25	CVD	CVD	NNP
cord-006860-a3b8hyyr	3768	26	)	)	-RRB-
cord-006860-a3b8hyyr	3768	27	,	,	,
cord-006860-a3b8hyyr	3768	28	diabetes	diabete	VBZ
cord-006860-a3b8hyyr	3768	29	mellitus	mellitus	NN
cord-006860-a3b8hyyr	3768	30	(	(	-LRB-
cord-006860-a3b8hyyr	3768	31	Dm	Dm	NNP
cord-006860-a3b8hyyr	3768	32	]	]	-RRB-
cord-006860-a3b8hyyr	3768	33	and	and	CC
cord-006860-a3b8hyyr	3768	34	in	in	IN
cord-006860-a3b8hyyr	3768	35	healthy	healthy	JJ
cord-006860-a3b8hyyr	3768	36	control	control	NN
cord-006860-a3b8hyyr	3768	37	persons	person	NNS
cord-006860-a3b8hyyr	3768	38	(	(	-LRB-
cord-006860-a3b8hyyr	3768	39	Control	Control	NNP
cord-006860-a3b8hyyr	3768	40	)	)	-RRB-
cord-006860-a3b8hyyr	3768	41	.	.	.
cord-006860-a3b8hyyr	3769	1	Variation	variation	NN
cord-006860-a3b8hyyr	3769	2	coefficient	coefficient	NN
cord-006860-a3b8hyyr	3769	3	of	of	IN
cord-006860-a3b8hyyr	3769	4	the	the	DT
cord-006860-a3b8hyyr	3769	5	method	method	NN
cord-006860-a3b8hyyr	3769	6	is	be	VBZ
cord-006860-a3b8hyyr	3769	7	3.7	3.7	CD
cord-006860-a3b8hyyr	3769	8	(	(	-LRB-
cord-006860-a3b8hyyr	3769	9	PRP	PRP	NNP
cord-006860-a3b8hyyr	3769	10	)	)	-RRB-
cord-006860-a3b8hyyr	3769	11	and	and	CC
cord-006860-a3b8hyyr	3769	12	4.4	4.4	CD
cord-006860-a3b8hyyr	3769	13	(	(	-LRB-
cord-006860-a3b8hyyr	3769	14	TC	TC	NNP
cord-006860-a3b8hyyr	3769	15	)	)	-RRB-
cord-006860-a3b8hyyr	3769	16	respectively	respectively	RB
cord-006860-a3b8hyyr	3770	1	(	(	-LRB-
cord-006860-a3b8hyyr	3770	2	Coulter	Coulter	NNP
cord-006860-a3b8hyyr	3770	3	counter	counter	NN
cord-006860-a3b8hyyr	3770	4	)	)	-RRB-
cord-006860-a3b8hyyr	3770	5	.	.	.
cord-006860-a3b8hyyr	3771	1	Differences	difference	NNS
cord-006860-a3b8hyyr	3771	2	to	to	IN
cord-006860-a3b8hyyr	3771	3	the	the	DT
cord-006860-a3b8hyyr	3771	4	control	control	NN
cord-006860-a3b8hyyr	3771	5	group	group	NN
cord-006860-a3b8hyyr	3771	6	are	be	VBP
cord-006860-a3b8hyyr	3771	7	significant	significant	JJ
cord-006860-a3b8hyyr	3771	8	.	.	.
cord-006860-a3b8hyyr	3772	1	Changes	change	NNS
cord-006860-a3b8hyyr	3772	2	in	in	IN
cord-006860-a3b8hyyr	3772	3	the	the	DT
cord-006860-a3b8hyyr	3772	4	patient	patient	JJ
cord-006860-a3b8hyyr	3772	5	groups	group	NNS
cord-006860-a3b8hyyr	3772	6	in	in	IN
cord-006860-a3b8hyyr	3772	7	dispensaires	dispensaire	NNS
cord-006860-a3b8hyyr	3772	8	follow	follow	VBP
cord-006860-a3b8hyyr	3772	9	up	up	RB
cord-006860-a3b8hyyr	3772	10	5	5	CD
cord-006860-a3b8hyyr	3772	11	years	year	NNS
cord-006860-a3b8hyyr	3772	12	are	be	VBP
cord-006860-a3b8hyyr	3772	13	also	also	RB
cord-006860-a3b8hyyr	3772	14	significant	significant	JJ
cord-006860-a3b8hyyr	3772	15	.	.	.
cord-006860-a3b8hyyr	3773	1	NICARDIPIN	NICARDIPIN	NNP
cord-006860-a3b8hyyr	3774	1	-INDUCED	-INDUCED	.
cord-006860-a3b8hyyr	3775	1	IMMUNTHROMBOCYTOPENIA	IMMUNTHROMBOCYTOPENIA	NNP
cord-006860-a3b8hyyr	3775	2	P.	P.	NNP
cord-006860-a3b8hyyr	3775	3	Eichler	Eichler	NNP
cord-006860-a3b8hyyr	3775	4	1	1	CD
cord-006860-a3b8hyyr	3775	5	,	,	,
cord-006860-a3b8hyyr	3775	6	C.	C.	NNP
cord-006860-a3b8hyyr	3775	7	Hinrichs	Hinrichs	NNP
cord-006860-a3b8hyyr	3775	8	2	2	CD
cord-006860-a3b8hyyr	3775	9	,	,	,
cord-006860-a3b8hyyr	3776	1	g	g	NNP
cord-006860-a3b8hyyr	3776	2	Greinacher	Greinacher	NNP
cord-006860-a3b8hyyr	3776	3	l	l	NN
cord-006860-a3b8hyyr	3776	4	i.	i.	NN
cord-006860-a3b8hyyr	3777	1	Institut	Institut	NNP
cord-006860-a3b8hyyr	3777	2	fur	fur	NN
cord-006860-a3b8hyyr	3777	3	immunologic	immunologic	JJ
cord-006860-a3b8hyyr	3778	1	und	und	NNP
cord-006860-a3b8hyyr	3779	1	Transfusionsmedizin	Transfusionsmedizin	NNP
cord-006860-a3b8hyyr	3779	2	,	,	,
cord-006860-a3b8hyyr	3779	3	Ernst	Ernst	NNP
cord-006860-a3b8hyyr	3779	4	-	-	HYPH
cord-006860-a3b8hyyr	3779	5	Moritz	Moritz	NNP
cord-006860-a3b8hyyr	3779	6	-	-	HYPH
cord-006860-a3b8hyyr	3779	7	Arndt	Arndt	NNP
cord-006860-a3b8hyyr	3779	8	-	-	HYPH
cord-006860-a3b8hyyr	3779	9	Universitat	Universitat	NNP
cord-006860-a3b8hyyr	3779	10	Greifswald	Greifswald	NNP
cord-006860-a3b8hyyr	3779	11	,	,	,
cord-006860-a3b8hyyr	3779	12	2	2	CD
cord-006860-a3b8hyyr	3779	13	.	.	.
cord-006860-a3b8hyyr	3780	1	Deister	Deister	NNP
cord-006860-a3b8hyyr	3780	2	-	-	HYPH
cord-006860-a3b8hyyr	3780	3	S0ntel	S0ntel	NNP
cord-006860-a3b8hyyr	3780	4	-	-	HYPH
cord-006860-a3b8hyyr	3780	5	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	3780	6	,	,	,
cord-006860-a3b8hyyr	3780	7	Bad	bad	JJ
cord-006860-a3b8hyyr	3780	8	M0nder	M0nder	NNP
cord-006860-a3b8hyyr	3780	9	Drug	drug	NN
cord-006860-a3b8hyyr	3780	10	-	-	HYPH
cord-006860-a3b8hyyr	3780	11	dependent	dependent	JJ
cord-006860-a3b8hyyr	3780	12	immune	immune	NN
cord-006860-a3b8hyyr	3780	13	-	-	HYPH
cord-006860-a3b8hyyr	3780	14	thrombocytopenias	thrombocytopenia	NNS
cord-006860-a3b8hyyr	3780	15	are	be	VBP
cord-006860-a3b8hyyr	3780	16	a	a	DT
cord-006860-a3b8hyyr	3780	17	rare	rare	JJ
cord-006860-a3b8hyyr	3780	18	but	but	CC
cord-006860-a3b8hyyr	3780	19	clinically	clinically	RB
cord-006860-a3b8hyyr	3780	20	important	important	JJ
cord-006860-a3b8hyyr	3780	21	variant	variant	NN
cord-006860-a3b8hyyr	3780	22	of	of	IN
cord-006860-a3b8hyyr	3780	23	immune	immune	NN
cord-006860-a3b8hyyr	3780	24	-	-	HYPH
cord-006860-a3b8hyyr	3780	25	thrombocytopenias	thrombocytopenia	NNS
cord-006860-a3b8hyyr	3780	26	.	.	.
cord-006860-a3b8hyyr	3781	1	Patients	patient	NNS
cord-006860-a3b8hyyr	3781	2	are	be	VBP
cord-006860-a3b8hyyr	3781	3	at	at	IN
cord-006860-a3b8hyyr	3781	4	risk	risk	NN
cord-006860-a3b8hyyr	3781	5	to	to	TO
cord-006860-a3b8hyyr	3781	6	suffer	suffer	VB
cord-006860-a3b8hyyr	3781	7	from	from	IN
cord-006860-a3b8hyyr	3781	8	severe	severe	JJ
cord-006860-a3b8hyyr	3781	9	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	3781	10	complications	complication	NNS
cord-006860-a3b8hyyr	3781	11	.	.	.
cord-006860-a3b8hyyr	3782	1	Especially	especially	RB
cord-006860-a3b8hyyr	3782	2	in	in	IN
cord-006860-a3b8hyyr	3782	3	patients	patient	NNS
cord-006860-a3b8hyyr	3782	4	receiving	receive	VBG
cord-006860-a3b8hyyr	3782	5	multiple	multiple	JJ
cord-006860-a3b8hyyr	3782	6	drugs	drug	NNS
cord-006860-a3b8hyyr	3782	7	,	,	,
cord-006860-a3b8hyyr	3782	8	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	3782	9	of	of	IN
cord-006860-a3b8hyyr	3782	10	drug	drug	NN
cord-006860-a3b8hyyr	3782	11	-	-	HYPH
cord-006860-a3b8hyyr	3782	12	dependent	dependent	JJ
cord-006860-a3b8hyyr	3782	13	immune	immune	NN
cord-006860-a3b8hyyr	3782	14	-	-	HYPH
cord-006860-a3b8hyyr	3782	15	thromboeytopenia	thromboeytopenia	NNP
cord-006860-a3b8hyyr	3782	16	is	be	VBZ
cord-006860-a3b8hyyr	3782	17	often	often	RB
cord-006860-a3b8hyyr	3782	18	difficult	difficult	JJ
cord-006860-a3b8hyyr	3782	19	.	.	.
cord-006860-a3b8hyyr	3783	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3783	2	report	report	VBP
cord-006860-a3b8hyyr	3783	3	the	the	DT
cord-006860-a3b8hyyr	3783	4	case	case	NN
cord-006860-a3b8hyyr	3783	5	of	of	IN
cord-006860-a3b8hyyr	3783	6	a	a	DT
cord-006860-a3b8hyyr	3783	7	71	71	CD
cord-006860-a3b8hyyr	3783	8	year	year	NN
cord-006860-a3b8hyyr	3783	9	old	old	JJ
cord-006860-a3b8hyyr	3783	10	male	male	JJ
cord-006860-a3b8hyyr	3783	11	patient	patient	NN
cord-006860-a3b8hyyr	3783	12	who	who	WP
cord-006860-a3b8hyyr	3783	13	received	receive	VBD
cord-006860-a3b8hyyr	3783	14	Allopurinol	Allopurinol	NNP
cord-006860-a3b8hyyr	3783	15	,	,	,
cord-006860-a3b8hyyr	3783	16	Captopril	Captopril	NNP
cord-006860-a3b8hyyr	3783	17	,	,	,
cord-006860-a3b8hyyr	3783	18	Digitoxin	Digitoxin	NNP
cord-006860-a3b8hyyr	3783	19	,	,	,
cord-006860-a3b8hyyr	3783	20	Furosemid	Furosemid	NNP
cord-006860-a3b8hyyr	3783	21	,	,	,
cord-006860-a3b8hyyr	3783	22	and	and	CC
cord-006860-a3b8hyyr	3783	23	Nieardipin	Nieardipin	NNP
cord-006860-a3b8hyyr	3783	24	.	.	.
cord-006860-a3b8hyyr	3784	1	The	the	DT
cord-006860-a3b8hyyr	3784	2	patient	patient	NN
cord-006860-a3b8hyyr	3784	3	presented	present	VBN
cord-006860-a3b8hyyr	3784	4	with	with	IN
cord-006860-a3b8hyyr	3784	5	hematomas	hematoma	NNS
cord-006860-a3b8hyyr	3784	6	(	(	-LRB-
cord-006860-a3b8hyyr	3784	7	pit	pit	NN
cord-006860-a3b8hyyr	3784	8	.	.	.
cord-006860-a3b8hyyr	3785	1	count	count	VB
cord-006860-a3b8hyyr	3785	2	<	<	XX
cord-006860-a3b8hyyr	3785	3	10	10	CD
cord-006860-a3b8hyyr	3785	4	G	g	NN
cord-006860-a3b8hyyr	3785	5	/	/	SYM
cord-006860-a3b8hyyr	3785	6	l	l	NN
cord-006860-a3b8hyyr	3785	7	)	)	-RRB-
cord-006860-a3b8hyyr	3785	8	and	and	CC
cord-006860-a3b8hyyr	3785	9	later	later	RB
cord-006860-a3b8hyyr	3785	10	developed	develop	VBD
cord-006860-a3b8hyyr	3785	11	bone	bone	NN
cord-006860-a3b8hyyr	3785	12	marrow	marrow	NN
cord-006860-a3b8hyyr	3785	13	dysplasia	dysplasia	NN
cord-006860-a3b8hyyr	3785	14	.	.	.
cord-006860-a3b8hyyr	3786	1	In	in	IN
cord-006860-a3b8hyyr	3786	2	an	an	DT
cord-006860-a3b8hyyr	3786	3	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	3786	4	using	use	VBG
cord-006860-a3b8hyyr	3786	5	whole	whole	JJ
cord-006860-a3b8hyyr	3786	6	platelets	platelet	NNS
cord-006860-a3b8hyyr	3786	7	and	and	CC
cord-006860-a3b8hyyr	3786	8	patient	patient	JJ
cord-006860-a3b8hyyr	3786	9	serum	serum	NN
cord-006860-a3b8hyyr	3786	10	,	,	,
cord-006860-a3b8hyyr	3786	11	a	a	DT
cord-006860-a3b8hyyr	3786	12	weak	weak	JJ
cord-006860-a3b8hyyr	3786	13	reactivity	reactivity	NN
cord-006860-a3b8hyyr	3786	14	in	in	IN
cord-006860-a3b8hyyr	3786	15	the	the	DT
cord-006860-a3b8hyyr	3786	16	presence	presence	NN
cord-006860-a3b8hyyr	3786	17	of	of	IN
cord-006860-a3b8hyyr	3786	18	furosemid	furosemid	NNP
cord-006860-a3b8hyyr	3786	19	,	,	,
cord-006860-a3b8hyyr	3786	20	but	but	CC
cord-006860-a3b8hyyr	3786	21	a	a	DT
cord-006860-a3b8hyyr	3786	22	stronger	strong	JJR
cord-006860-a3b8hyyr	3786	23	reactivity	reactivity	NN
cord-006860-a3b8hyyr	3786	24	in	in	IN
cord-006860-a3b8hyyr	3786	25	the	the	DT
cord-006860-a3b8hyyr	3786	26	presence	presence	NN
cord-006860-a3b8hyyr	3786	27	of	of	IN
cord-006860-a3b8hyyr	3786	28	nicardipin	nicardipin	NNP
cord-006860-a3b8hyyr	3786	29	(	(	-LRB-
cord-006860-a3b8hyyr	3786	30	Antagonil	Antagonil	NNP
cord-006860-a3b8hyyr	3786	31	,	,	,
cord-006860-a3b8hyyr	3786	32	CIBA	CIBA	NNP
cord-006860-a3b8hyyr	3786	33	-	-	HYPH
cord-006860-a3b8hyyr	3786	34	Geigy	Geigy	NNP
cord-006860-a3b8hyyr	3786	35	)	)	-RRB-
cord-006860-a3b8hyyr	3786	36	could	could	MD
cord-006860-a3b8hyyr	3786	37	be	be	VB
cord-006860-a3b8hyyr	3786	38	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	3786	39	.	.	.
cord-006860-a3b8hyyr	3787	1	The	the	DT
cord-006860-a3b8hyyr	3787	2	reaction	reaction	NN
cord-006860-a3b8hyyr	3787	3	pattern	pattern	NN
cord-006860-a3b8hyyr	3787	4	is	be	VBZ
cord-006860-a3b8hyyr	3787	5	given	give	VBN
cord-006860-a3b8hyyr	3787	6	in	in	IN
cord-006860-a3b8hyyr	3787	7	the	the	DT
cord-006860-a3b8hyyr	3787	8	The	the	DT
cord-006860-a3b8hyyr	3787	9	enzyme	enzyme	NN
cord-006860-a3b8hyyr	3787	10	-	-	HYPH
cord-006860-a3b8hyyr	3787	11	immunological	immunological	JJ
cord-006860-a3b8hyyr	3787	12	determination	determination	NN
cord-006860-a3b8hyyr	3787	13	of	of	IN
cord-006860-a3b8hyyr	3787	14	soluble	soluble	JJ
cord-006860-a3b8hyyr	3787	15	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3787	16	(	(	-LRB-
cord-006860-a3b8hyyr	3787	17	SF	SF	NNP
cord-006860-a3b8hyyr	3787	18	)	)	-RRB-
cord-006860-a3b8hyyr	3787	19	proved	prove	VBD
cord-006860-a3b8hyyr	3787	20	to	to	TO
cord-006860-a3b8hyyr	3787	21	be	be	VB
cord-006860-a3b8hyyr	3787	22	highly	highly	RB
cord-006860-a3b8hyyr	3787	23	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	3787	24	and	and	CC
cord-006860-a3b8hyyr	3787	25	specific	specific	JJ
cord-006860-a3b8hyyr	3787	26	.	.	.
cord-006860-a3b8hyyr	3788	1	This	this	DT
cord-006860-a3b8hyyr	3788	2	SF	SF	NNP
cord-006860-a3b8hyyr	3788	3	-	-	HYPH
cord-006860-a3b8hyyr	3788	4	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	3788	5	detected	detect	VBD
cord-006860-a3b8hyyr	3788	6	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3788	7	hacking	hacking	NN
cord-006860-a3b8hyyr	3788	8	fibrinopeptide	fibrinopeptide	RB
cord-006860-a3b8hyyr	3788	9	A	a	NN
cord-006860-a3b8hyyr	3788	10	(	(	-LRB-
cord-006860-a3b8hyyr	3788	11	FPA	FPA	NNP
cord-006860-a3b8hyyr	3788	12	)	)	-RRB-
cord-006860-a3b8hyyr	3788	13	via	via	IN
cord-006860-a3b8hyyr	3788	14	the	the	DT
cord-006860-a3b8hyyr	3788	15	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	3788	16	antibody	antibody	NN
cord-006860-a3b8hyyr	3788	17	2t35	2t35	CD
cord-006860-a3b8hyyr	3788	18	specific	specific	JJ
cord-006860-a3b8hyyr	3788	19	for	for	IN
cord-006860-a3b8hyyr	3788	20	the	the	DT
cord-006860-a3b8hyyr	3788	21	neoepitope	neoepitope	NN
cord-006860-a3b8hyyr	3788	22	generated	generate	VBN
cord-006860-a3b8hyyr	3788	23	on	on	IN
cord-006860-a3b8hyyr	3788	24	the	the	DT
cord-006860-a3b8hyyr	3788	25	Aa	Aa	NNP
cord-006860-a3b8hyyr	3788	26	-	-	HYPH
cord-006860-a3b8hyyr	3788	27	chain	chain	NN
cord-006860-a3b8hyyr	3788	28	after	after	IN
cord-006860-a3b8hyyr	3788	29	the	the	DT
cord-006860-a3b8hyyr	3788	30	split	split	NN
cord-006860-a3b8hyyr	3788	31	of	of	IN
cord-006860-a3b8hyyr	3788	32	FPA	FPA	NNP
cord-006860-a3b8hyyr	3788	33	.	.	.
cord-006860-a3b8hyyr	3789	1	Lill	Lill	NNP
cord-006860-a3b8hyyr	3789	2	et	et	NNP
cord-006860-a3b8hyyr	3789	3	al	al	NNP
cord-006860-a3b8hyyr	3789	4	.	.	.
cord-006860-a3b8hyyr	3790	1	recently	recently	RB
cord-006860-a3b8hyyr	3790	2	introduced	introduce	VBD
cord-006860-a3b8hyyr	3790	3	a	a	DT
cord-006860-a3b8hyyr	3790	4	new	new	JJ
cord-006860-a3b8hyyr	3790	5	assay	assay	NN
cord-006860-a3b8hyyr	3790	6	modification	modification	NN
cord-006860-a3b8hyyr	3790	7	which	which	WDT
cord-006860-a3b8hyyr	3790	8	utilizes	utilize	VBZ
cord-006860-a3b8hyyr	3790	9	the	the	DT
cord-006860-a3b8hyyr	3790	10	same	same	JJ
cord-006860-a3b8hyyr	3790	11	antibody	antibody	NN
cord-006860-a3b8hyyr	3790	12	as	as	IN
cord-006860-a3b8hyyr	3790	13	the	the	DT
cord-006860-a3b8hyyr	3790	14	old	old	JJ
cord-006860-a3b8hyyr	3790	15	one	one	NN
cord-006860-a3b8hyyr	3790	16	but	but	CC
cord-006860-a3b8hyyr	3790	17	takes	take	VBZ
cord-006860-a3b8hyyr	3790	18	advantage	advantage	NN
cord-006860-a3b8hyyr	3790	19	of	of	IN
cord-006860-a3b8hyyr	3790	20	a	a	DT
cord-006860-a3b8hyyr	3790	21	pretreatment	pretreatment	NN
cord-006860-a3b8hyyr	3790	22	of	of	IN
cord-006860-a3b8hyyr	3790	23	plasma	plasma	NN
cord-006860-a3b8hyyr	3790	24	specimens	specimen	NNS
cord-006860-a3b8hyyr	3790	25	with	with	IN
cord-006860-a3b8hyyr	3790	26	KSCN	KSCN	NNP
cord-006860-a3b8hyyr	3790	27	.	.	.
cord-006860-a3b8hyyr	3791	1	This	this	DT
cord-006860-a3b8hyyr	3791	2	strong	strong	JJ
cord-006860-a3b8hyyr	3791	3	chaotropic	chaotropic	JJ
cord-006860-a3b8hyyr	3791	4	ion	ion	NN
cord-006860-a3b8hyyr	3791	5	is	be	VBZ
cord-006860-a3b8hyyr	3791	6	used	use	VBN
cord-006860-a3b8hyyr	3791	7	to	to	TO
cord-006860-a3b8hyyr	3791	8	dissociate	dissociate	VB
cord-006860-a3b8hyyr	3791	9	the	the	DT
cord-006860-a3b8hyyr	3791	10	various	various	JJ
cord-006860-a3b8hyyr	3791	11	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3791	12	complexes	complex	NNS
cord-006860-a3b8hyyr	3791	13	possibly	possibly	RB
cord-006860-a3b8hyyr	3791	14	hiding	hide	VBG
cord-006860-a3b8hyyr	3791	15	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3791	16	epitopes	epitope	NNS
cord-006860-a3b8hyyr	3791	17	.	.	.
cord-006860-a3b8hyyr	3792	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	3792	2	was	be	VBD
cord-006860-a3b8hyyr	3792	3	the	the	DT
cord-006860-a3b8hyyr	3792	4	aim	aim	NN
cord-006860-a3b8hyyr	3792	5	of	of	IN
cord-006860-a3b8hyyr	3792	6	this	this	DT
cord-006860-a3b8hyyr	3792	7	study	study	NN
cord-006860-a3b8hyyr	3792	8	,	,	,
cord-006860-a3b8hyyr	3792	9	therefore	therefore	RB
cord-006860-a3b8hyyr	3792	10	,	,	,
cord-006860-a3b8hyyr	3792	11	to	to	TO
cord-006860-a3b8hyyr	3792	12	compare	compare	VB
cord-006860-a3b8hyyr	3792	13	the	the	DT
cord-006860-a3b8hyyr	3792	14	two	two	CD
cord-006860-a3b8hyyr	3792	15	SF	SF	NNP
cord-006860-a3b8hyyr	3792	16	-	-	HYPH
cord-006860-a3b8hyyr	3792	17	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	3792	18	modifications	modification	NNS
cord-006860-a3b8hyyr	3792	19	(	(	-LRB-
cord-006860-a3b8hyyr	3792	20	with	with	IN
cord-006860-a3b8hyyr	3792	21	and	and	CC
cord-006860-a3b8hyyr	3792	22	without	without	IN
cord-006860-a3b8hyyr	3792	23	KSCN	KSCN	NNP
cord-006860-a3b8hyyr	3792	24	-	-	HYPH
cord-006860-a3b8hyyr	3792	25	pretreatment	pretreatment	NN
cord-006860-a3b8hyyr	3792	26	of	of	IN
cord-006860-a3b8hyyr	3792	27	specimens	specimen	NNS
cord-006860-a3b8hyyr	3792	28	)	)	-RRB-
cord-006860-a3b8hyyr	3792	29	.	.	.
cord-006860-a3b8hyyr	3793	1	In	in	IN
cord-006860-a3b8hyyr	3793	2	order	order	NN
cord-006860-a3b8hyyr	3793	3	to	to	TO
cord-006860-a3b8hyyr	3793	4	examine	examine	VB
cord-006860-a3b8hyyr	3793	5	the	the	DT
cord-006860-a3b8hyyr	3793	6	dynamics	dynamic	NNS
cord-006860-a3b8hyyr	3793	7	of	of	IN
cord-006860-a3b8hyyr	3793	8	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3793	9	-	-	HYPH
cord-006860-a3b8hyyr	3793	10	induced	induce	VBN
cord-006860-a3b8hyyr	3793	11	fibrin(ogen	fibrin(ogen	NN
cord-006860-a3b8hyyr	3793	12	)	)	-RRB-
cord-006860-a3b8hyyr	3793	13	metabolism	metabolism	NN
cord-006860-a3b8hyyr	3793	14	we	-PRON-	PRP
cord-006860-a3b8hyyr	3793	15	made	make	VBD
cord-006860-a3b8hyyr	3793	16	course	course	NN
cord-006860-a3b8hyyr	3793	17	observations	observation	NNS
cord-006860-a3b8hyyr	3793	18	in	in	IN
cord-006860-a3b8hyyr	3793	19	patients	patient	NNS
cord-006860-a3b8hyyr	3793	20	with	with	IN
cord-006860-a3b8hyyr	3793	21	a	a	DT
cord-006860-a3b8hyyr	3793	22	certain	certain	JJ
cord-006860-a3b8hyyr	3793	23	form	form	NN
cord-006860-a3b8hyyr	3793	24	of	of	IN
cord-006860-a3b8hyyr	3793	25	septicemia	septicemia	NN
cord-006860-a3b8hyyr	3793	26	.	.	.
cord-006860-a3b8hyyr	3794	1	Both	both	DT
cord-006860-a3b8hyyr	3794	2	assay	assay	NN
cord-006860-a3b8hyyr	3794	3	modifications	modification	NNS
cord-006860-a3b8hyyr	3794	4	detected	detect	VBN
cord-006860-a3b8hyyr	3794	5	fibrin(ogen	fibrin(ogen	CD
cord-006860-a3b8hyyr	3794	6	)	)	-RRB-
cord-006860-a3b8hyyr	3794	7	derivatives	derivative	NNS
cord-006860-a3b8hyyr	3794	8	which	which	WDT
cord-006860-a3b8hyyr	3794	9	differed	differ	VBD
cord-006860-a3b8hyyr	3794	10	considerably	considerably	RB
cord-006860-a3b8hyyr	3794	11	in	in	IN
cord-006860-a3b8hyyr	3794	12	kinetics	kinetics	NNP
cord-006860-a3b8hyyr	3794	13	(	(	-LRB-
cord-006860-a3b8hyyr	3794	14	n=	n=	NNP
cord-006860-a3b8hyyr	3794	15	160	160	CD
cord-006860-a3b8hyyr	3794	16	samples	sample	NNS
cord-006860-a3b8hyyr	3794	17	from	from	IN
cord-006860-a3b8hyyr	3794	18	10	10	CD
cord-006860-a3b8hyyr	3794	19	courses	course	NNS
cord-006860-a3b8hyyr	3794	20	)	)	-RRB-
cord-006860-a3b8hyyr	3794	21	.	.	.
cord-006860-a3b8hyyr	3795	1	The	the	DT
cord-006860-a3b8hyyr	3795	2	former	former	JJ
cord-006860-a3b8hyyr	3795	3	SF	SF	NNP
cord-006860-a3b8hyyr	3795	4	-	-	HYPH
cord-006860-a3b8hyyr	3795	5	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	3795	6	(	(	-LRB-
cord-006860-a3b8hyyr	3795	7	no	no	DT
cord-006860-a3b8hyyr	3795	8	KSCN	KSCN	NNP
cord-006860-a3b8hyyr	3795	9	)	)	-RRB-
cord-006860-a3b8hyyr	3795	10	correlated	correlate	VBD
cord-006860-a3b8hyyr	3795	11	well	well	RB
cord-006860-a3b8hyyr	3795	12	with	with	IN
cord-006860-a3b8hyyr	3795	13	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3795	14	fragments	fragment	NNS
cord-006860-a3b8hyyr	3795	15	,	,	,
cord-006860-a3b8hyyr	3795	16	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3795	17	-	-	HYPH
cord-006860-a3b8hyyr	3795	18	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3795	19	!	!	.
cord-006860-a3b8hyyr	3796	1	11	11	CD
cord-006860-a3b8hyyr	3796	2	-complexes	-complexe	NNS
cord-006860-a3b8hyyr	3796	3	and	and	CC
cord-006860-a3b8hyyr	3796	4	with	with	IN
cord-006860-a3b8hyyr	3796	5	the	the	DT
cord-006860-a3b8hyyr	3796	6	release	release	NN
cord-006860-a3b8hyyr	3796	7	of	of	IN
cord-006860-a3b8hyyr	3796	8	fibrinopeptide	fibrinopeptide	RB
cord-006860-a3b8hyyr	3796	9	A	a	NN
cord-006860-a3b8hyyr	3796	10	(	(	-LRB-
cord-006860-a3b8hyyr	3796	11	r	r	NN
cord-006860-a3b8hyyr	3796	12	>	>	XX
cord-006860-a3b8hyyr	3797	1	0.96	0.96	CD
cord-006860-a3b8hyyr	3797	2	,	,	,
cord-006860-a3b8hyyr	3797	3	n=	n=	NNP
cord-006860-a3b8hyyr	3797	4	151	151	CD
cord-006860-a3b8hyyr	3797	5	)	)	-RRB-
cord-006860-a3b8hyyr	3797	6	.	.	.
cord-006860-a3b8hyyr	3798	1	Results	result	NNS
cord-006860-a3b8hyyr	3798	2	of	of	IN
cord-006860-a3b8hyyr	3798	3	the	the	DT
cord-006860-a3b8hyyr	3798	4	new	new	JJ
cord-006860-a3b8hyyr	3798	5	SF	SF	NNP
cord-006860-a3b8hyyr	3798	6	-	-	HYPH
cord-006860-a3b8hyyr	3798	7	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	3798	8	with	with	IN
cord-006860-a3b8hyyr	3798	9	KSCN	KSCN	NNP
cord-006860-a3b8hyyr	3798	10	pretreatment	pretreatment	NN
cord-006860-a3b8hyyr	3798	11	of	of	IN
cord-006860-a3b8hyyr	3798	12	patients	patient	NNS
cord-006860-a3b8hyyr	3798	13	'	'	POS
cord-006860-a3b8hyyr	3798	14	plasma	plasma	NN
cord-006860-a3b8hyyr	3798	15	,	,	,
cord-006860-a3b8hyyr	3798	16	however	however	RB
cord-006860-a3b8hyyr	3798	17	,	,	,
cord-006860-a3b8hyyr	3798	18	correlated	correlate	VBD
cord-006860-a3b8hyyr	3798	19	conspiciously	conspiciously	RB
cord-006860-a3b8hyyr	3798	20	well	well	RB
cord-006860-a3b8hyyr	3798	21	with	with	IN
cord-006860-a3b8hyyr	3798	22	D	d	NN
cord-006860-a3b8hyyr	3798	23	-	-	HYPH
cord-006860-a3b8hyyr	3798	24	dimer	dimer	NN
cord-006860-a3b8hyyr	3798	25	levels	level	NNS
cord-006860-a3b8hyyr	3798	26	(	(	-LRB-
cord-006860-a3b8hyyr	3799	1	r	r	LS
cord-006860-a3b8hyyr	3799	2	>	>	XX
cord-006860-a3b8hyyr	3799	3	0.94	0.94	CD
cord-006860-a3b8hyyr	3799	4	)	)	-RRB-
cord-006860-a3b8hyyr	3800	1	but	but	CC
cord-006860-a3b8hyyr	3800	2	distinctly	distinctly	RB
cord-006860-a3b8hyyr	3800	3	less	less	JJR
cord-006860-a3b8hyyr	3800	4	with	with	IN
cord-006860-a3b8hyyr	3800	5	the	the	DT
cord-006860-a3b8hyyr	3800	6	markers	marker	NNS
cord-006860-a3b8hyyr	3800	7	of	of	IN
cord-006860-a3b8hyyr	3800	8	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3800	9	generation	generation	NN
cord-006860-a3b8hyyr	3800	10	(	(	-LRB-
cord-006860-a3b8hyyr	3800	11	-0.12	-0.12	:
cord-006860-a3b8hyyr	3800	12	<	<	XX
cord-006860-a3b8hyyr	3800	13	r	r	XX
cord-006860-a3b8hyyr	3800	14	<	<	XX
cord-006860-a3b8hyyr	3800	15	0.29	0.29	CD
cord-006860-a3b8hyyr	3800	16	)	)	-RRB-
cord-006860-a3b8hyyr	3800	17	.	.	.
cord-006860-a3b8hyyr	3801	1	This	this	DT
cord-006860-a3b8hyyr	3801	2	good	good	JJ
cord-006860-a3b8hyyr	3801	3	correlation	correlation	NN
cord-006860-a3b8hyyr	3801	4	with	with	IN
cord-006860-a3b8hyyr	3801	5	D	d	NN
cord-006860-a3b8hyyr	3801	6	-	-	HYPH
cord-006860-a3b8hyyr	3801	7	dimer	dimer	NN
cord-006860-a3b8hyyr	3801	8	levels	level	NNS
cord-006860-a3b8hyyr	3801	9	was	be	VBD
cord-006860-a3b8hyyr	3801	10	unaccountable	unaccountable	JJ
cord-006860-a3b8hyyr	3801	11	since	since	IN
cord-006860-a3b8hyyr	3801	12	the	the	DT
cord-006860-a3b8hyyr	3801	13	D	d	NN
cord-006860-a3b8hyyr	3801	14	-	-	HYPH
cord-006860-a3b8hyyr	3801	15	dimer	dimer	NN
cord-006860-a3b8hyyr	3801	16	maximum	maximum	NN
cord-006860-a3b8hyyr	3801	17	occured	occur	VBD
cord-006860-a3b8hyyr	3801	18	significantly	significantly	RB
cord-006860-a3b8hyyr	3801	19	later	later	RB
cord-006860-a3b8hyyr	3801	20	than	than	IN
cord-006860-a3b8hyyr	3801	21	the	the	DT
cord-006860-a3b8hyyr	3801	22	peak	peak	NN
cord-006860-a3b8hyyr	3801	23	of	of	IN
cord-006860-a3b8hyyr	3801	24	markers	marker	NNS
cord-006860-a3b8hyyr	3801	25	of	of	IN
cord-006860-a3b8hyyr	3801	26	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	3801	27	generation	generation	NN
cord-006860-a3b8hyyr	3801	28	(	(	-LRB-
cord-006860-a3b8hyyr	3801	29	p	p	NN
cord-006860-a3b8hyyr	3801	30	<	<	XX
cord-006860-a3b8hyyr	3801	31	0.05	0.05	CD
cord-006860-a3b8hyyr	3801	32	)	)	-RRB-
cord-006860-a3b8hyyr	3801	33	.	.	.
cord-006860-a3b8hyyr	3802	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	3802	2	,	,	,
cord-006860-a3b8hyyr	3802	3	KSCNpretreatment	kscnpretreatment	NN
cord-006860-a3b8hyyr	3802	4	of	of	IN
cord-006860-a3b8hyyr	3802	5	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3802	6	specimens	specimen	NNS
cord-006860-a3b8hyyr	3802	7	seems	seem	VBZ
cord-006860-a3b8hyyr	3802	8	to	to	TO
cord-006860-a3b8hyyr	3802	9	lead	lead	VB
cord-006860-a3b8hyyr	3802	10	to	to	IN
cord-006860-a3b8hyyr	3802	11	a	a	DT
cord-006860-a3b8hyyr	3802	12	change	change	NN
cord-006860-a3b8hyyr	3802	13	in	in	IN
cord-006860-a3b8hyyr	3802	14	the	the	DT
cord-006860-a3b8hyyr	3802	15	specificity	specificity	NN
cord-006860-a3b8hyyr	3802	16	of	of	IN
cord-006860-a3b8hyyr	3802	17	the	the	DT
cord-006860-a3b8hyyr	3802	18	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3802	19	assay	assay	NN
cord-006860-a3b8hyyr	3802	20	despite	despite	IN
cord-006860-a3b8hyyr	3802	21	usage	usage	NN
cord-006860-a3b8hyyr	3802	22	of	of	IN
cord-006860-a3b8hyyr	3802	23	the	the	DT
cord-006860-a3b8hyyr	3802	24	same	same	JJ
cord-006860-a3b8hyyr	3802	25	catching	catch	VBG
cord-006860-a3b8hyyr	3802	26	antibody	antibody	NN
cord-006860-a3b8hyyr	3802	27	.	.	.
cord-006860-a3b8hyyr	3803	1	Different	different	JJ
cord-006860-a3b8hyyr	3803	2	half	half	JJ
cord-006860-a3b8hyyr	3803	3	-	-	HYPH
cord-006860-a3b8hyyr	3803	4	iifes	iifes	NN
cord-006860-a3b8hyyr	3803	5	of	of	IN
cord-006860-a3b8hyyr	3803	6	differently	differently	RB
cord-006860-a3b8hyyr	3803	7	composed	compose	VBN
cord-006860-a3b8hyyr	3803	8	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3803	9	complexes	complex	NNS
cord-006860-a3b8hyyr	3803	10	should	should	MD
cord-006860-a3b8hyyr	3803	11	be	be	VB
cord-006860-a3b8hyyr	3803	12	considered	consider	VBN
cord-006860-a3b8hyyr	3803	13	in	in	IN
cord-006860-a3b8hyyr	3803	14	trying	try	VBG
cord-006860-a3b8hyyr	3803	15	to	to	TO
cord-006860-a3b8hyyr	3803	16	explain	explain	VB
cord-006860-a3b8hyyr	3803	17	the	the	DT
cord-006860-a3b8hyyr	3803	18	findings	finding	NNS
cord-006860-a3b8hyyr	3803	19	.	.	.
cord-006860-a3b8hyyr	3804	1	Nevertheless	nevertheless	RB
cord-006860-a3b8hyyr	3804	2	,	,	,
cord-006860-a3b8hyyr	3804	3	the	the	DT
cord-006860-a3b8hyyr	3804	4	results	result	NNS
cord-006860-a3b8hyyr	3804	5	of	of	IN
cord-006860-a3b8hyyr	3804	6	the	the	DT
cord-006860-a3b8hyyr	3804	7	former	former	JJ
cord-006860-a3b8hyyr	3804	8	assay	assay	NN
cord-006860-a3b8hyyr	3804	9	without	without	IN
cord-006860-a3b8hyyr	3804	10	KSCN	KSCN	NNP
cord-006860-a3b8hyyr	3804	11	-	-	HYPH
cord-006860-a3b8hyyr	3804	12	treatment	treatment	NN
cord-006860-a3b8hyyr	3804	13	correlated	correlate	VBD
cord-006860-a3b8hyyr	3804	14	much	much	RB
cord-006860-a3b8hyyr	3804	15	better	better	RB
cord-006860-a3b8hyyr	3804	16	with	with	IN
cord-006860-a3b8hyyr	3804	17	the	the	DT
cord-006860-a3b8hyyr	3804	18	well	well	RB
cord-006860-a3b8hyyr	3804	19	-	-	HYPH
cord-006860-a3b8hyyr	3804	20	known	know	VBN
cord-006860-a3b8hyyr	3804	21	dynamics	dynamic	NNS
cord-006860-a3b8hyyr	3804	22	of	of	IN
cord-006860-a3b8hyyr	3804	23	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3804	24	-	-	HYPH
cord-006860-a3b8hyyr	3804	25	induced	induce	VBN
cord-006860-a3b8hyyr	3804	26	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3804	27	generation	generation	NN
cord-006860-a3b8hyyr	3804	28	during	during	IN
cord-006860-a3b8hyyr	3804	29	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	3804	30	activation	activation	NN
cord-006860-a3b8hyyr	3804	31	than	than	IN
cord-006860-a3b8hyyr	3804	32	the	the	DT
cord-006860-a3b8hyyr	3804	33	data	datum	NNS
cord-006860-a3b8hyyr	3804	34	from	from	IN
cord-006860-a3b8hyyr	3804	35	the	the	DT
cord-006860-a3b8hyyr	3804	36	new	new	JJ
cord-006860-a3b8hyyr	3804	37	assay	assay	NN
cord-006860-a3b8hyyr	3804	38	modification	modification	NN
cord-006860-a3b8hyyr	3804	39	.	.	.
cord-006860-a3b8hyyr	3805	1	Consequently	consequently	RB
cord-006860-a3b8hyyr	3805	2	,	,	,
cord-006860-a3b8hyyr	3805	3	further	further	JJ
cord-006860-a3b8hyyr	3805	4	examinations	examination	NNS
cord-006860-a3b8hyyr	3805	5	are	be	VBP
cord-006860-a3b8hyyr	3805	6	necessary	necessary	JJ
cord-006860-a3b8hyyr	3805	7	to	to	TO
cord-006860-a3b8hyyr	3805	8	specify	specify	VB
cord-006860-a3b8hyyr	3805	9	the	the	DT
cord-006860-a3b8hyyr	3805	10	effect	effect	NN
cord-006860-a3b8hyyr	3805	11	of	of	IN
cord-006860-a3b8hyyr	3805	12	KSCN	KSCN	NNP
cord-006860-a3b8hyyr	3805	13	on	on	IN
cord-006860-a3b8hyyr	3805	14	soluble	soluble	JJ
cord-006860-a3b8hyyr	3805	15	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3805	16	complexes	complex	NNS
cord-006860-a3b8hyyr	3805	17	and	and	CC
cord-006860-a3b8hyyr	3805	18	the	the	DT
cord-006860-a3b8hyyr	3805	19	resulting	result	VBG
cord-006860-a3b8hyyr	3805	20	assay	assay	NN
cord-006860-a3b8hyyr	3805	21	specificity	specificity	NN
cord-006860-a3b8hyyr	3805	22	.	.	.
cord-006860-a3b8hyyr	3806	1	A	a	DT
cord-006860-a3b8hyyr	3806	2	rapid	rapid	JJ
cord-006860-a3b8hyyr	3806	3	assay	assay	NN
cord-006860-a3b8hyyr	3806	4	for	for	IN
cord-006860-a3b8hyyr	3806	5	the	the	DT
cord-006860-a3b8hyyr	3806	6	determination	determination	NN
cord-006860-a3b8hyyr	3806	7	of	of	IN
cord-006860-a3b8hyyr	3806	8	the	the	DT
cord-006860-a3b8hyyr	3806	9	Primary	Primary	NNP
cord-006860-a3b8hyyr	3806	10	Hemostasis	Hemostasis	NNP
cord-006860-a3b8hyyr	3806	11	Potential	Potential	NNP
cord-006860-a3b8hyyr	3806	12	(	(	-LRB-
cord-006860-a3b8hyyr	3806	13	PHP	PHP	NNP
cord-006860-a3b8hyyr	3806	14	)	)	-RRB-
cord-006860-a3b8hyyr	3806	15	of	of	IN
cord-006860-a3b8hyyr	3806	16	whole	whole	JJ
cord-006860-a3b8hyyr	3806	17	blood	blood	NN
cord-006860-a3b8hyyr	3806	18	has	have	VBZ
cord-006860-a3b8hyyr	3806	19	been	be	VBN
cord-006860-a3b8hyyr	3806	20	developed	develop	VBN
cord-006860-a3b8hyyr	3807	1	(	(	-LRB-
cord-006860-a3b8hyyr	3807	2	Kundu	Kundu	NNP
cord-006860-a3b8hyyr	3807	3	et	et	NNP
cord-006860-a3b8hyyr	3807	4	al	al	NNP
cord-006860-a3b8hyyr	3807	5	,	,	,
cord-006860-a3b8hyyr	3807	6	1995	1995	CD
cord-006860-a3b8hyyr	3807	7	)	)	-RRB-
cord-006860-a3b8hyyr	3807	8	from	from	IN
cord-006860-a3b8hyyr	3807	9	the	the	DT
cord-006860-a3b8hyyr	3807	10	original	original	JJ
cord-006860-a3b8hyyr	3807	11	method	method	NN
cord-006860-a3b8hyyr	3807	12	of	of	IN
cord-006860-a3b8hyyr	3807	13	Kratzer	Kratzer	NNP
cord-006860-a3b8hyyr	3807	14	and	and	CC
cord-006860-a3b8hyyr	3807	15	Born	Born	NNP
cord-006860-a3b8hyyr	3807	16	.	.	.
cord-006860-a3b8hyyr	3808	1	The	the	DT
cord-006860-a3b8hyyr	3808	2	new	new	JJ
cord-006860-a3b8hyyr	3808	3	system	system	NN
cord-006860-a3b8hyyr	3808	4	employs	employ	VBZ
cord-006860-a3b8hyyr	3808	5	a	a	DT
cord-006860-a3b8hyyr	3808	6	disposable	disposable	JJ
cord-006860-a3b8hyyr	3808	7	test	test	NN
cord-006860-a3b8hyyr	3808	8	cartridge	cartridge	NN
cord-006860-a3b8hyyr	3808	9	which	which	WDT
cord-006860-a3b8hyyr	3808	10	holds	hold	VBZ
cord-006860-a3b8hyyr	3808	11	the	the	DT
cord-006860-a3b8hyyr	3808	12	sample	sample	NN
cord-006860-a3b8hyyr	3808	13	(	(	-LRB-
cord-006860-a3b8hyyr	3808	14	citrated	citrate	VBN
cord-006860-a3b8hyyr	3808	15	whole	whole	JJ
cord-006860-a3b8hyyr	3808	16	blood	blood	NN
cord-006860-a3b8hyyr	3808	17	)	)	-RRB-
cord-006860-a3b8hyyr	3808	18	and	and	CC
cord-006860-a3b8hyyr	3808	19	all	all	DT
cord-006860-a3b8hyyr	3808	20	components	component	NNS
cord-006860-a3b8hyyr	3808	21	for	for	IN
cord-006860-a3b8hyyr	3808	22	the	the	DT
cord-006860-a3b8hyyr	3808	23	tests	test	NNS
cord-006860-a3b8hyyr	3808	24	at	at	IN
cord-006860-a3b8hyyr	3808	25	the	the	DT
cord-006860-a3b8hyyr	3808	26	same	same	JJ
cord-006860-a3b8hyyr	3808	27	time	time	NN
cord-006860-a3b8hyyr	3808	28	.	.	.
cord-006860-a3b8hyyr	3809	1	The	the	DT
cord-006860-a3b8hyyr	3809	2	test	test	NN
cord-006860-a3b8hyyr	3809	3	procedure	procedure	NN
cord-006860-a3b8hyyr	3809	4	is	be	VBZ
cord-006860-a3b8hyyr	3809	5	very	very	RB
cord-006860-a3b8hyyr	3809	6	simple	simple	JJ
cord-006860-a3b8hyyr	3809	7	.	.	.
cord-006860-a3b8hyyr	3810	1	The	the	DT
cord-006860-a3b8hyyr	3810	2	cartridge	cartridge	NN
cord-006860-a3b8hyyr	3810	3	is	be	VBZ
cord-006860-a3b8hyyr	3810	4	loaded	load	VBN
cord-006860-a3b8hyyr	3810	5	with	with	IN
cord-006860-a3b8hyyr	3810	6	-500	-500	NN
cord-006860-a3b8hyyr	3810	7	p.l	p.l	NNP
cord-006860-a3b8hyyr	3810	8	citrated	citrate	VBD
cord-006860-a3b8hyyr	3810	9	whole	whole	JJ
cord-006860-a3b8hyyr	3810	10	blood	blood	NN
cord-006860-a3b8hyyr	3810	11	and	and	CC
cord-006860-a3b8hyyr	3810	12	is	be	VBZ
cord-006860-a3b8hyyr	3810	13	inserted	insert	VBN
cord-006860-a3b8hyyr	3810	14	into	into	IN
cord-006860-a3b8hyyr	3810	15	the	the	DT
cord-006860-a3b8hyyr	3810	16	Platelet	platelet	NN
cord-006860-a3b8hyyr	3810	17	Function	function	NN
cord-006860-a3b8hyyr	3810	18	Analyzer	Analyzer	NNP
cord-006860-a3b8hyyr	3810	19	(	(	-LRB-
cord-006860-a3b8hyyr	3810	20	PFA	PFA	NNP
cord-006860-a3b8hyyr	3810	21	100aaw	100aaw	CD
cord-006860-a3b8hyyr	3810	22	)	)	-RRB-
cord-006860-a3b8hyyr	3810	23	.	.	.
cord-006860-a3b8hyyr	3811	1	The	the	DT
cord-006860-a3b8hyyr	3811	2	test	test	NN
cord-006860-a3b8hyyr	3811	3	is	be	VBZ
cord-006860-a3b8hyyr	3811	4	started	start	VBN
cord-006860-a3b8hyyr	3811	5	automatically	automatically	RB
cord-006860-a3b8hyyr	3811	6	after	after	IN
cord-006860-a3b8hyyr	3811	7	a	a	DT
cord-006860-a3b8hyyr	3811	8	preincubation	preincubation	NN
cord-006860-a3b8hyyr	3811	9	phase	phase	NN
cord-006860-a3b8hyyr	3811	10	of	of	IN
cord-006860-a3b8hyyr	3811	11	2.5	2.5	CD
cord-006860-a3b8hyyr	3811	12	rain	rain	NN
cord-006860-a3b8hyyr	3811	13	.	.	.
cord-006860-a3b8hyyr	3812	1	The	the	DT
cord-006860-a3b8hyyr	3812	2	reaction	reaction	NN
cord-006860-a3b8hyyr	3812	3	starts	start	VBZ
cord-006860-a3b8hyyr	3812	4	with	with	IN
cord-006860-a3b8hyyr	3812	5	the	the	DT
cord-006860-a3b8hyyr	3812	6	contact	contact	NN
cord-006860-a3b8hyyr	3812	7	of	of	IN
cord-006860-a3b8hyyr	3812	8	the	the	DT
cord-006860-a3b8hyyr	3812	9	whole	whole	JJ
cord-006860-a3b8hyyr	3812	10	blood	blood	NN
cord-006860-a3b8hyyr	3812	11	and	and	CC
cord-006860-a3b8hyyr	3812	12	the	the	DT
cord-006860-a3b8hyyr	3812	13	capillary	capillary	NN
cord-006860-a3b8hyyr	3812	14	which	which	WDT
cord-006860-a3b8hyyr	3812	15	is	be	VBZ
cord-006860-a3b8hyyr	3812	16	connected	connect	VBN
cord-006860-a3b8hyyr	3812	17	with	with	IN
cord-006860-a3b8hyyr	3812	18	a	a	DT
cord-006860-a3b8hyyr	3812	19	collagerdephinephrin	collagerdephinephrin	NN
cord-006860-a3b8hyyr	3812	20	coated	coat	VBN
cord-006860-a3b8hyyr	3812	21	membrane	membrane	NN
cord-006860-a3b8hyyr	3812	22	with	with	IN
cord-006860-a3b8hyyr	3812	23	a	a	DT
cord-006860-a3b8hyyr	3812	24	small	small	JJ
cord-006860-a3b8hyyr	3812	25	aperture	aperture	NN
cord-006860-a3b8hyyr	3812	26	inside	inside	IN
cord-006860-a3b8hyyr	3812	27	the	the	DT
cord-006860-a3b8hyyr	3812	28	test	test	NN
cord-006860-a3b8hyyr	3812	29	cartridge	cartridge	NN
cord-006860-a3b8hyyr	3812	30	.	.	.
cord-006860-a3b8hyyr	3813	1	Under	under	IN
cord-006860-a3b8hyyr	3813	2	constant	constant	JJ
cord-006860-a3b8hyyr	3813	3	negative	negative	JJ
cord-006860-a3b8hyyr	3813	4	pressure	pressure	NN
cord-006860-a3b8hyyr	3813	5	the	the	DT
cord-006860-a3b8hyyr	3813	6	sample	sample	NN
cord-006860-a3b8hyyr	3813	7	is	be	VBZ
cord-006860-a3b8hyyr	3813	8	aspirated	aspirate	VBN
cord-006860-a3b8hyyr	3813	9	and	and	CC
cord-006860-a3b8hyyr	3813	10	through	through	IN
cord-006860-a3b8hyyr	3813	11	the	the	DT
cord-006860-a3b8hyyr	3813	12	contact	contact	NN
cord-006860-a3b8hyyr	3813	13	ofplatelets	ofplatelet	NNS
cord-006860-a3b8hyyr	3813	14	and	and	CC
cord-006860-a3b8hyyr	3813	15	vWF	vwf	NN
cord-006860-a3b8hyyr	3813	16	with	with	IN
cord-006860-a3b8hyyr	3813	17	collagen	collagen	NN
cord-006860-a3b8hyyr	3813	18	adherence	adherence	NN
cord-006860-a3b8hyyr	3813	19	and	and	CC
cord-006860-a3b8hyyr	3813	20	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3813	21	begins	begin	VBZ
cord-006860-a3b8hyyr	3813	22	.	.	.
cord-006860-a3b8hyyr	3814	1	The	the	DT
cord-006860-a3b8hyyr	3814	2	adhesion	adhesion	NN
cord-006860-a3b8hyyr	3814	3	and	and	CC
cord-006860-a3b8hyyr	3814	4	aggregation	aggregation	NN
cord-006860-a3b8hyyr	3814	5	process	process	NN
cord-006860-a3b8hyyr	3814	6	leads	lead	VBZ
cord-006860-a3b8hyyr	3814	7	to	to	IN
cord-006860-a3b8hyyr	3814	8	the	the	DT
cord-006860-a3b8hyyr	3814	9	formation	formation	NN
cord-006860-a3b8hyyr	3814	10	of	of	IN
cord-006860-a3b8hyyr	3814	11	a	a	DT
cord-006860-a3b8hyyr	3814	12	platelet	platelet	NN
cord-006860-a3b8hyyr	3814	13	plug	plug	NN
cord-006860-a3b8hyyr	3814	14	which	which	WDT
cord-006860-a3b8hyyr	3814	15	obstructs	obstruct	VBZ
cord-006860-a3b8hyyr	3814	16	the	the	DT
cord-006860-a3b8hyyr	3814	17	flow	flow	NN
cord-006860-a3b8hyyr	3814	18	through	through	IN
cord-006860-a3b8hyyr	3814	19	the	the	DT
cord-006860-a3b8hyyr	3814	20	aperture	aperture	NN
cord-006860-a3b8hyyr	3814	21	.	.	.
cord-006860-a3b8hyyr	3815	1	The	the	DT
cord-006860-a3b8hyyr	3815	2	result	result	NN
cord-006860-a3b8hyyr	3815	3	of	of	IN
cord-006860-a3b8hyyr	3815	4	the	the	DT
cord-006860-a3b8hyyr	3815	5	PHP	PHP	NNP
cord-006860-a3b8hyyr	3815	6	is	be	VBZ
cord-006860-a3b8hyyr	3815	7	reported	report	VBN
cord-006860-a3b8hyyr	3815	8	as	as	IN
cord-006860-a3b8hyyr	3815	9	closure	closure	NN
cord-006860-a3b8hyyr	3815	10	time	time	NN
cord-006860-a3b8hyyr	3815	11	(	(	-LRB-
cord-006860-a3b8hyyr	3815	12	CT	CT	NNP
cord-006860-a3b8hyyr	3815	13	)	)	-RRB-
cord-006860-a3b8hyyr	3815	14	.	.	.
cord-006860-a3b8hyyr	3816	1	Additional	additional	JJ
cord-006860-a3b8hyyr	3816	2	parameters	parameter	NNS
cord-006860-a3b8hyyr	3816	3	such	such	JJ
cord-006860-a3b8hyyr	3816	4	as	as	IN
cord-006860-a3b8hyyr	3816	5	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3816	6	volumes	volume	NNS
cord-006860-a3b8hyyr	3816	7	are	be	VBP
cord-006860-a3b8hyyr	3816	8	possible	possible	JJ
cord-006860-a3b8hyyr	3816	9	as	as	RB
cord-006860-a3b8hyyr	3816	10	well	well	RB
cord-006860-a3b8hyyr	3816	11	.	.	.
cord-006860-a3b8hyyr	3817	1	First	first	JJ
cord-006860-a3b8hyyr	3817	2	results	result	NNS
cord-006860-a3b8hyyr	3817	3	show	show	VBP
cord-006860-a3b8hyyr	3817	4	good	good	JJ
cord-006860-a3b8hyyr	3817	5	reproducibility	reproducibility	NN
cord-006860-a3b8hyyr	3817	6	,	,	,
cord-006860-a3b8hyyr	3817	7	normal	normal	JJ
cord-006860-a3b8hyyr	3817	8	values	value	NNS
cord-006860-a3b8hyyr	3817	9	in	in	IN
cord-006860-a3b8hyyr	3817	10	the	the	DT
cord-006860-a3b8hyyr	3817	11	range	range	NN
cord-006860-a3b8hyyr	3817	12	of	of	IN
cord-006860-a3b8hyyr	3817	13	up	up	IN
cord-006860-a3b8hyyr	3817	14	to	to	TO
cord-006860-a3b8hyyr	3817	15	150	150	CD
cord-006860-a3b8hyyr	3817	16	sec	sec	NNS
cord-006860-a3b8hyyr	3817	17	.	.	.
cord-006860-a3b8hyyr	3818	1	and	and	CC
cord-006860-a3b8hyyr	3818	2	a	a	DT
cord-006860-a3b8hyyr	3818	3	good	good	JJ
cord-006860-a3b8hyyr	3818	4	discrimination	discrimination	NN
cord-006860-a3b8hyyr	3818	5	of	of	IN
cord-006860-a3b8hyyr	3818	6	healthy	healthy	JJ
cord-006860-a3b8hyyr	3818	7	donors	donor	NNS
cord-006860-a3b8hyyr	3818	8	from	from	IN
cord-006860-a3b8hyyr	3818	9	patients	patient	NNS
cord-006860-a3b8hyyr	3818	10	with	with	IN
cord-006860-a3b8hyyr	3818	11	congenital	congenital	JJ
cord-006860-a3b8hyyr	3818	12	or	or	CC
cord-006860-a3b8hyyr	3818	13	acquired	acquire	VBN
cord-006860-a3b8hyyr	3818	14	platelet	platelet	NN
cord-006860-a3b8hyyr	3818	15	dysfunctions	dysfunction	NNS
cord-006860-a3b8hyyr	3818	16	.	.	.
cord-006860-a3b8hyyr	3819	1	The	the	DT
cord-006860-a3b8hyyr	3819	2	system	system	NN
cord-006860-a3b8hyyr	3819	3	detects	detect	VBZ
cord-006860-a3b8hyyr	3819	4	aspirin	aspirin	NN
cord-006860-a3b8hyyr	3819	5	induced	induce	VBN
cord-006860-a3b8hyyr	3819	6	thrombocyte	thrombocyte	NNP
cord-006860-a3b8hyyr	3819	7	function	function	NN
cord-006860-a3b8hyyr	3819	8	defects	defect	NNS
cord-006860-a3b8hyyr	3819	9	and	and	CC
cord-006860-a3b8hyyr	3819	10	von	von	NNP
cord-006860-a3b8hyyr	3819	11	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	3819	12	disease	disease	NN
cord-006860-a3b8hyyr	3819	13	.	.	.
cord-006860-a3b8hyyr	3820	1	In	in	IN
cord-006860-a3b8hyyr	3820	2	ease	ease	NN
cord-006860-a3b8hyyr	3820	3	of	of	IN
cord-006860-a3b8hyyr	3820	4	an	an	DT
cord-006860-a3b8hyyr	3820	5	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	3820	6	result	result	NN
cord-006860-a3b8hyyr	3820	7	in	in	IN
cord-006860-a3b8hyyr	3820	8	the	the	DT
cord-006860-a3b8hyyr	3820	9	collagerdepinephrin	collagerdepinephrin	NN
cord-006860-a3b8hyyr	3820	10	system	system	NN
cord-006860-a3b8hyyr	3820	11	a	a	DT
cord-006860-a3b8hyyr	3820	12	second	second	JJ
cord-006860-a3b8hyyr	3820	13	type	type	NN
cord-006860-a3b8hyyr	3820	14	of	of	IN
cord-006860-a3b8hyyr	3820	15	cartridge	cartridge	NN
cord-006860-a3b8hyyr	3820	16	with	with	IN
cord-006860-a3b8hyyr	3820	17	a	a	DT
cord-006860-a3b8hyyr	3820	18	collagerdADP	collagerdadp	FW
cord-006860-a3b8hyyr	3820	19	coating	coating	NN
cord-006860-a3b8hyyr	3820	20	can	can	MD
cord-006860-a3b8hyyr	3820	21	be	be	VB
cord-006860-a3b8hyyr	3820	22	employed	employ	VBN
cord-006860-a3b8hyyr	3820	23	.	.	.
cord-006860-a3b8hyyr	3821	1	In	in	IN
cord-006860-a3b8hyyr	3821	2	the	the	DT
cord-006860-a3b8hyyr	3821	3	majority	majority	NN
cord-006860-a3b8hyyr	3821	4	of	of	IN
cord-006860-a3b8hyyr	3821	5	cases	case	NNS
cord-006860-a3b8hyyr	3821	6	aspirin	aspirin	NN
cord-006860-a3b8hyyr	3821	7	induced	induce	VBN
cord-006860-a3b8hyyr	3821	8	dysfunctions	dysfunction	NNS
cord-006860-a3b8hyyr	3821	9	are	be	VBP
cord-006860-a3b8hyyr	3821	10	normalized	normalize	VBN
cord-006860-a3b8hyyr	3821	11	and	and	CC
cord-006860-a3b8hyyr	3821	12	could	could	MD
cord-006860-a3b8hyyr	3821	13	thus	thus	RB
cord-006860-a3b8hyyr	3821	14	detect	detect	VB
cord-006860-a3b8hyyr	3821	15	aspirin	aspirin	NN
cord-006860-a3b8hyyr	3821	16	use	use	NN
cord-006860-a3b8hyyr	3821	17	.	.	.
cord-006860-a3b8hyyr	3822	1	The	the	DT
cord-006860-a3b8hyyr	3822	2	proposed	propose	VBN
cord-006860-a3b8hyyr	3822	3	system	system	NN
cord-006860-a3b8hyyr	3822	4	may	may	MD
cord-006860-a3b8hyyr	3822	5	be	be	VB
cord-006860-a3b8hyyr	3822	6	a	a	DT
cord-006860-a3b8hyyr	3822	7	valuable	valuable	JJ
cord-006860-a3b8hyyr	3822	8	tool	tool	NN
cord-006860-a3b8hyyr	3822	9	for	for	IN
cord-006860-a3b8hyyr	3822	10	routine	routine	JJ
cord-006860-a3b8hyyr	3822	11	assessment	assessment	NN
cord-006860-a3b8hyyr	3822	12	of	of	IN
cord-006860-a3b8hyyr	3822	13	the	the	DT
cord-006860-a3b8hyyr	3822	14	primary	primary	JJ
cord-006860-a3b8hyyr	3822	15	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	3822	16	potential	potential	NN
cord-006860-a3b8hyyr	3822	17	in	in	IN
cord-006860-a3b8hyyr	3822	18	a	a	DT
cord-006860-a3b8hyyr	3822	19	routine	routine	JJ
cord-006860-a3b8hyyr	3822	20	citrate	citrate	NN
cord-006860-a3b8hyyr	3822	21	blood	blood	NN
cord-006860-a3b8hyyr	3822	22	sample	sample	NN
cord-006860-a3b8hyyr	3822	23	laboratory	laboratory	NN
cord-006860-a3b8hyyr	3822	24	.	.	.
cord-006860-a3b8hyyr	3823	1	inducing	induce	VBG
cord-006860-a3b8hyyr	3823	2	mental	mental	JJ
cord-006860-a3b8hyyr	3823	3	stress	stress	NN
cord-006860-a3b8hyyr	3823	4	in	in	IN
cord-006860-a3b8hyyr	3823	5	20	20	CD
cord-006860-a3b8hyyr	3823	6	young	young	JJ
cord-006860-a3b8hyyr	3823	7	healthy	healthy	JJ
cord-006860-a3b8hyyr	3823	8	male	male	JJ
cord-006860-a3b8hyyr	3823	9	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	3823	10	aged	age	VBN
cord-006860-a3b8hyyr	3823	11	20	20	CD
cord-006860-a3b8hyyr	3823	12	to	to	TO
cord-006860-a3b8hyyr	3823	13	40	40	CD
cord-006860-a3b8hyyr	3823	14	)	)	-RRB-
cord-006860-a3b8hyyr	3823	15	,	,	,
cord-006860-a3b8hyyr	3823	16	ears	ear	NNS
cord-006860-a3b8hyyr	3823	17	with	with	IN
cord-006860-a3b8hyyr	3823	18	no	no	DT
cord-006860-a3b8hyyr	3823	19	previous	previous	JJ
cord-006860-a3b8hyyr	3823	20	history	history	NN
cord-006860-a3b8hyyr	3823	21	of	of	IN
cord-006860-a3b8hyyr	3823	22	thmmbophilia	thmmbophilia	NNP
cord-006860-a3b8hyyr	3823	23	or	or	CC
cord-006860-a3b8hyyr	3823	24	a	a	DT
cord-006860-a3b8hyyr	3823	25	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	3823	26	diathesis	diathesis	NN
cord-006860-a3b8hyyr	3823	27	was	be	VBD
cord-006860-a3b8hyyr	3823	28	performed	perform	VBN
cord-006860-a3b8hyyr	3823	29	by	by	IN
cord-006860-a3b8hyyr	3823	30	a	a	DT
cord-006860-a3b8hyyr	3823	31	first	first	JJ
cord-006860-a3b8hyyr	3823	32	time	time	NN
cord-006860-a3b8hyyr	3823	33	parachute	parachute	NN
cord-006860-a3b8hyyr	3823	34	descent	descent	NN
cord-006860-a3b8hyyr	3823	35	from	from	IN
cord-006860-a3b8hyyr	3823	36	an	an	DT
cord-006860-a3b8hyyr	3823	37	altitude	altitude	NN
cord-006860-a3b8hyyr	3823	38	of	of	IN
cord-006860-a3b8hyyr	3823	39	1000	1000	CD
cord-006860-a3b8hyyr	3823	40	meters	meter	NNS
cord-006860-a3b8hyyr	3823	41	.	.	.
cord-006860-a3b8hyyr	3824	1	The	the	DT
cord-006860-a3b8hyyr	3824	2	purpose	purpose	NN
cord-006860-a3b8hyyr	3824	3	of	of	IN
cord-006860-a3b8hyyr	3824	4	this	this	DT
cord-006860-a3b8hyyr	3824	5	investigation	investigation	NN
cord-006860-a3b8hyyr	3824	6	was	be	VBD
cord-006860-a3b8hyyr	3824	7	to	to	TO
cord-006860-a3b8hyyr	3824	8	find	find	VB
cord-006860-a3b8hyyr	3824	9	out	out	RP
cord-006860-a3b8hyyr	3824	10	whether	whether	IN
cord-006860-a3b8hyyr	3824	11	there	there	EX
cord-006860-a3b8hyyr	3824	12	are	be	VBP
cord-006860-a3b8hyyr	3824	13	any	any	DT
cord-006860-a3b8hyyr	3824	14	changes	change	NNS
cord-006860-a3b8hyyr	3824	15	in	in	IN
cord-006860-a3b8hyyr	3824	16	the	the	DT
cord-006860-a3b8hyyr	3824	17	corpuscular	corpuscular	JJ
cord-006860-a3b8hyyr	3824	18	and	and	CC
cord-006860-a3b8hyyr	3824	19	plasmatic	plasmatic	JJ
cord-006860-a3b8hyyr	3824	20	fractions	fraction	NNS
cord-006860-a3b8hyyr	3824	21	of	of	IN
cord-006860-a3b8hyyr	3824	22	peripheral	peripheral	JJ
cord-006860-a3b8hyyr	3824	23	blood	blood	NN
cord-006860-a3b8hyyr	3824	24	.	.	.
cord-006860-a3b8hyyr	3825	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3825	2	were	be	VBD
cord-006860-a3b8hyyr	3825	3	especially	especially	RB
cord-006860-a3b8hyyr	3825	4	interested	interested	JJ
cord-006860-a3b8hyyr	3825	5	in	in	IN
cord-006860-a3b8hyyr	3825	6	elucidating	elucidate	VBG
cord-006860-a3b8hyyr	3825	7	changes	change	NNS
cord-006860-a3b8hyyr	3825	8	in	in	IN
cord-006860-a3b8hyyr	3825	9	the	the	DT
cord-006860-a3b8hyyr	3825	10	procoagulatory	procoagulatory	NN
cord-006860-a3b8hyyr	3825	11	and/or	and/or	CC
cord-006860-a3b8hyyr	3825	12	fibrinolysis	fibrinolysis	NNP
cord-006860-a3b8hyyr	3825	13	systems	system	NNS
cord-006860-a3b8hyyr	3825	14	.	.	.
cord-006860-a3b8hyyr	3826	1	Venous	venous	JJ
cord-006860-a3b8hyyr	3826	2	blood	blood	NN
cord-006860-a3b8hyyr	3826	3	samples	sample	NNS
cord-006860-a3b8hyyr	3826	4	were	be	VBD
cord-006860-a3b8hyyr	3826	5	obtained	obtain	VBN
cord-006860-a3b8hyyr	3826	6	directly	directly	RB
cord-006860-a3b8hyyr	3826	7	before	before	RB
cord-006860-a3b8hyyr	3826	8	and	and	CC
cord-006860-a3b8hyyr	3826	9	directly	directly	RB
cord-006860-a3b8hyyr	3826	10	after	after	IN
cord-006860-a3b8hyyr	3826	11	the	the	DT
cord-006860-a3b8hyyr	3826	12	jump	jump	NN
cord-006860-a3b8hyyr	3826	13	.	.	.
cord-006860-a3b8hyyr	3827	1	Flight	flight	NN
cord-006860-a3b8hyyr	3827	2	time	time	NN
cord-006860-a3b8hyyr	3827	3	from	from	IN
cord-006860-a3b8hyyr	3827	4	the	the	DT
cord-006860-a3b8hyyr	3827	5	departure	departure	NN
cord-006860-a3b8hyyr	3827	6	of	of	IN
cord-006860-a3b8hyyr	3827	7	the	the	DT
cord-006860-a3b8hyyr	3827	8	airplane	airplane	NN
cord-006860-a3b8hyyr	3827	9	to	to	IN
cord-006860-a3b8hyyr	3827	10	the	the	DT
cord-006860-a3b8hyyr	3827	11	landing	landing	NN
cord-006860-a3b8hyyr	3827	12	of	of	IN
cord-006860-a3b8hyyr	3827	13	the	the	DT
cord-006860-a3b8hyyr	3827	14	parachutists	parachutist	NNS
cord-006860-a3b8hyyr	3827	15	was	be	VBD
cord-006860-a3b8hyyr	3827	16	approximately	approximately	RB
cord-006860-a3b8hyyr	3827	17	20	20	CD
cord-006860-a3b8hyyr	3827	18	minutes	minute	NNS
cord-006860-a3b8hyyr	3827	19	.	.	.
cord-006860-a3b8hyyr	3828	1	The	the	DT
cord-006860-a3b8hyyr	3828	2	maximum	maximum	JJ
cord-006860-a3b8hyyr	3828	3	time	time	NN
cord-006860-a3b8hyyr	3828	4	that	that	WDT
cord-006860-a3b8hyyr	3828	5	elapsed	elapse	VBD
cord-006860-a3b8hyyr	3828	6	between	between	IN
cord-006860-a3b8hyyr	3828	7	the	the	DT
cord-006860-a3b8hyyr	3828	8	two	two	CD
cord-006860-a3b8hyyr	3828	9	blood	blood	NN
cord-006860-a3b8hyyr	3828	10	withdrawals	withdrawal	NNS
cord-006860-a3b8hyyr	3828	11	were	be	VBD
cord-006860-a3b8hyyr	3828	12	45	45	CD
cord-006860-a3b8hyyr	3828	13	minutes	minute	NNS
cord-006860-a3b8hyyr	3828	14	.	.	.
cord-006860-a3b8hyyr	3829	1	In	in	IN
cord-006860-a3b8hyyr	3829	2	a	a	DT
cord-006860-a3b8hyyr	3829	3	preliminary	preliminary	JJ
cord-006860-a3b8hyyr	3829	4	study	study	NN
cord-006860-a3b8hyyr	3829	5	with	with	IN
cord-006860-a3b8hyyr	3829	6	different	different	JJ
cord-006860-a3b8hyyr	3829	7	voinnteem	voinnteem	NN
cord-006860-a3b8hyyr	3829	8	,	,	,
cord-006860-a3b8hyyr	3829	9	certain	certain	JJ
cord-006860-a3b8hyyr	3829	10	fluid	fluid	JJ
cord-006860-a3b8hyyr	3829	11	imbalances	imbalance	NNS
cord-006860-a3b8hyyr	3829	12	had	have	VBD
cord-006860-a3b8hyyr	3829	13	been	be	VBN
cord-006860-a3b8hyyr	3829	14	observed	observe	VBN
cord-006860-a3b8hyyr	3829	15	.	.	.
cord-006860-a3b8hyyr	3830	1	Absolute	absolute	JJ
cord-006860-a3b8hyyr	3830	2	numbers	number	NNS
cord-006860-a3b8hyyr	3830	3	of	of	IN
cord-006860-a3b8hyyr	3830	4	leukoeytes	leukoeyte	NNS
cord-006860-a3b8hyyr	3830	5	(	(	-LRB-
cord-006860-a3b8hyyr	3830	6	6.9	6.9	CD
cord-006860-a3b8hyyr	3830	7	vs.	vs.	NN
cord-006860-a3b8hyyr	3830	8	9	9	CD
cord-006860-a3b8hyyr	3830	9	.	.	.
cord-006860-a3b8hyyr	3831	1	l	l	NNP
cord-006860-a3b8hyyr	3831	2	/	/	SYM
cord-006860-a3b8hyyr	3831	3	n0	n0	NNP
cord-006860-a3b8hyyr	3831	4	,	,	,
cord-006860-a3b8hyyr	3831	5	erythrocytes	erythrocyte	NNS
cord-006860-a3b8hyyr	3831	6	(	(	-LRB-
cord-006860-a3b8hyyr	3831	7	4.6	4.6	CD
cord-006860-a3b8hyyr	3831	8	vs.	vs.	IN
cord-006860-a3b8hyyr	3831	9	5.1	5.1	CD
cord-006860-a3b8hyyr	3831	10	/	/	SYM
cord-006860-a3b8hyyr	3831	11	pl	pl	NN
cord-006860-a3b8hyyr	3831	12	)	)	-RRB-
cord-006860-a3b8hyyr	3831	13	,	,	,
cord-006860-a3b8hyyr	3831	14	and	and	CC
cord-006860-a3b8hyyr	3831	15	platelets	platelet	NNS
cord-006860-a3b8hyyr	3831	16	(	(	-LRB-
cord-006860-a3b8hyyr	3831	17	246	246	CD
cord-006860-a3b8hyyr	3831	18	vs.276	vs.276	NNP
cord-006860-a3b8hyyr	3831	19	/	/	SYM
cord-006860-a3b8hyyr	3831	20	nl	nl	NNP
cord-006860-a3b8hyyr	3831	21	)	)	-RRB-
cord-006860-a3b8hyyr	3831	22	significantly	significantly	RB
cord-006860-a3b8hyyr	3831	23	increased	increase	VBD
cord-006860-a3b8hyyr	3831	24	(	(	-LRB-
cord-006860-a3b8hyyr	3831	25	p	p	NN
cord-006860-a3b8hyyr	3831	26	<	<	XX
cord-006860-a3b8hyyr	3831	27	.001	.001	CD
cord-006860-a3b8hyyr	3831	28	)	)	-RRB-
cord-006860-a3b8hyyr	3831	29	,	,	,
cord-006860-a3b8hyyr	3831	30	as	as	RB
cord-006860-a3b8hyyr	3831	31	well	well	RB
cord-006860-a3b8hyyr	3831	32	as	as	IN
cord-006860-a3b8hyyr	3831	33	the	the	DT
cord-006860-a3b8hyyr	3831	34	hemoglobin	hemoglobin	NN
cord-006860-a3b8hyyr	3831	35	concentration	concentration	NN
cord-006860-a3b8hyyr	3831	36	from	from	IN
cord-006860-a3b8hyyr	3831	37	145	145	CD
cord-006860-a3b8hyyr	3831	38	to	to	TO
cord-006860-a3b8hyyr	3831	39	156	156	CD
cord-006860-a3b8hyyr	3831	40	g	g	NN
cord-006860-a3b8hyyr	3831	41	/	/	SYM
cord-006860-a3b8hyyr	3831	42	L	l	NN
cord-006860-a3b8hyyr	3831	43	(	(	-LRB-
cord-006860-a3b8hyyr	3831	44	p	p	NN
cord-006860-a3b8hyyr	3831	45	<	<	XX
cord-006860-a3b8hyyr	3831	46	.018	.018	CD
cord-006860-a3b8hyyr	3831	47	)	)	-RRB-
cord-006860-a3b8hyyr	3831	48	.	.	.
cord-006860-a3b8hyyr	3832	1	Even	even	RB
cord-006860-a3b8hyyr	3832	2	though	though	IN
cord-006860-a3b8hyyr	3832	3	fluid	fluid	JJ
cord-006860-a3b8hyyr	3832	4	imbalances	imbalance	NNS
cord-006860-a3b8hyyr	3832	5	before	before	IN
cord-006860-a3b8hyyr	3832	6	and	and	CC
cord-006860-a3b8hyyr	3832	7	after	after	IN
cord-006860-a3b8hyyr	3832	8	the	the	DT
cord-006860-a3b8hyyr	3832	9	jump	jump	NN
cord-006860-a3b8hyyr	3832	10	had	have	VBD
cord-006860-a3b8hyyr	3832	11	practically	practically	RB
cord-006860-a3b8hyyr	3832	12	been	be	VBN
cord-006860-a3b8hyyr	3832	13	excluded	exclude	VBN
cord-006860-a3b8hyyr	3832	14	by	by	IN
cord-006860-a3b8hyyr	3832	15	measuring	measure	VBG
cord-006860-a3b8hyyr	3832	16	nearly	nearly	RB
cord-006860-a3b8hyyr	3832	17	identical	identical	JJ
cord-006860-a3b8hyyr	3832	18	hematoerit	hematoerit	JJ
cord-006860-a3b8hyyr	3832	19	values	value	NNS
cord-006860-a3b8hyyr	3832	20	(	(	-LRB-
cord-006860-a3b8hyyr	3832	21	.41	.41	NFP
cord-006860-a3b8hyyr	3832	22	vs	vs	IN
cord-006860-a3b8hyyr	3832	23	..	..	NFP
cord-006860-a3b8hyyr	3832	24	42	42	CD
cord-006860-a3b8hyyr	3832	25	)	)	-RRB-
cord-006860-a3b8hyyr	3832	26	,	,	,
cord-006860-a3b8hyyr	3832	27	we	-PRON-	PRP
cord-006860-a3b8hyyr	3832	28	noticed	notice	VBD
cord-006860-a3b8hyyr	3832	29	a	a	DT
cord-006860-a3b8hyyr	3832	30	marked	marked	JJ
cord-006860-a3b8hyyr	3832	31	drop	drop	NN
cord-006860-a3b8hyyr	3832	32	in	in	IN
cord-006860-a3b8hyyr	3832	33	aPTr	aptr	FW
cord-006860-a3b8hyyr	3832	34	(	(	-LRB-
cord-006860-a3b8hyyr	3832	35	27	27	CD
cord-006860-a3b8hyyr	3832	36	vs.	vs.	IN
cord-006860-a3b8hyyr	3832	37	23	23	CD
cord-006860-a3b8hyyr	3832	38	sec	sec	NNP
cord-006860-a3b8hyyr	3832	39	)	)	-RRB-
cord-006860-a3b8hyyr	3832	40	and	and	CC
cord-006860-a3b8hyyr	3832	41	a	a	DT
cord-006860-a3b8hyyr	3832	42	significant	significant	JJ
cord-006860-a3b8hyyr	3832	43	increase	increase	NN
cord-006860-a3b8hyyr	3832	44	in	in	IN
cord-006860-a3b8hyyr	3832	45	factor	factor	NN
cord-006860-a3b8hyyr	3832	46	VIII	VIII	NNP
cord-006860-a3b8hyyr	3832	47	~tivity	~tivity	NNP
cord-006860-a3b8hyyr	3832	48	.	.	.
cord-006860-a3b8hyyr	3833	1	As	as	IN
cord-006860-a3b8hyyr	3833	2	a	a	DT
cord-006860-a3b8hyyr	3833	3	direct	direct	JJ
cord-006860-a3b8hyyr	3833	4	stress	stress	NN
cord-006860-a3b8hyyr	3833	5	response	response	NN
cord-006860-a3b8hyyr	3833	6	,	,	,
cord-006860-a3b8hyyr	3833	7	we	-PRON-	PRP
cord-006860-a3b8hyyr	3833	8	found	find	VBD
cord-006860-a3b8hyyr	3833	9	a	a	DT
cord-006860-a3b8hyyr	3833	10	rise	rise	NN
cord-006860-a3b8hyyr	3833	11	in	in	IN
cord-006860-a3b8hyyr	3833	12	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3833	13	concentration	concentration	NN
cord-006860-a3b8hyyr	3833	14	(	(	-LRB-
cord-006860-a3b8hyyr	3833	15	2.4	2.4	CD
cord-006860-a3b8hyyr	3833	16	vs.	vs.	IN
cord-006860-a3b8hyyr	3833	17	2.8	2.8	CD
cord-006860-a3b8hyyr	3833	18	g	g	NN
cord-006860-a3b8hyyr	3833	19	/	/	SYM
cord-006860-a3b8hyyr	3833	20	l	l	NN
cord-006860-a3b8hyyr	3833	21	)	)	-RRB-
cord-006860-a3b8hyyr	3833	22	which	which	WDT
cord-006860-a3b8hyyr	3833	23	is	be	VBZ
cord-006860-a3b8hyyr	3833	24	one	one	CD
cord-006860-a3b8hyyr	3833	25	of	of	IN
cord-006860-a3b8hyyr	3833	26	the	the	DT
cord-006860-a3b8hyyr	3833	27	shortest	short	JJS
cord-006860-a3b8hyyr	3833	28	acting	act	VBG
cord-006860-a3b8hyyr	3833	29	acute	acute	JJ
cord-006860-a3b8hyyr	3833	30	phase	phase	NN
cord-006860-a3b8hyyr	3833	31	proteins	protein	NNS
cord-006860-a3b8hyyr	3833	32	.	.	.
cord-006860-a3b8hyyr	3834	1	Concerning	concern	VBG
cord-006860-a3b8hyyr	3834	2	reactive	reactive	JJ
cord-006860-a3b8hyyr	3834	3	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	3834	4	,	,	,
cord-006860-a3b8hyyr	3834	5	D	d	NN
cord-006860-a3b8hyyr	3834	6	-	-	HYPH
cord-006860-a3b8hyyr	3834	7	dimers	dimer	NNS
cord-006860-a3b8hyyr	3834	8	showed	show	VBD
cord-006860-a3b8hyyr	3834	9	an	an	DT
cord-006860-a3b8hyyr	3834	10	increase	increase	NN
cord-006860-a3b8hyyr	3834	11	in	in	IN
cord-006860-a3b8hyyr	3834	12	concentration	concentration	NN
cord-006860-a3b8hyyr	3834	13	from	from	IN
cord-006860-a3b8hyyr	3834	14	115	115	CD
cord-006860-a3b8hyyr	3834	15	lag	lag	NN
cord-006860-a3b8hyyr	3834	16	/	/	SYM
cord-006860-a3b8hyyr	3834	17	L	l	NN
cord-006860-a3b8hyyr	3834	18	to	to	IN
cord-006860-a3b8hyyr	3834	19	still	still	RB
cord-006860-a3b8hyyr	3834	20	normal	normal	JJ
cord-006860-a3b8hyyr	3834	21	values	value	NNS
cord-006860-a3b8hyyr	3834	22	of	of	IN
cord-006860-a3b8hyyr	3834	23	192	192	CD
cord-006860-a3b8hyyr	3834	24	lag	lag	NN
cord-006860-a3b8hyyr	3834	25	/	/	SYM
cord-006860-a3b8hyyr	3834	26	L	l	NN
cord-006860-a3b8hyyr	3834	27	,	,	,
cord-006860-a3b8hyyr	3834	28	which	which	WDT
cord-006860-a3b8hyyr	3834	29	was	be	VBD
cord-006860-a3b8hyyr	3834	30	not	not	RB
cord-006860-a3b8hyyr	3834	31	significant	significant	JJ
cord-006860-a3b8hyyr	3834	32	due	due	IN
cord-006860-a3b8hyyr	3834	33	to	to	IN
cord-006860-a3b8hyyr	3834	34	low	low	JJ
cord-006860-a3b8hyyr	3834	35	numbers	number	NNS
cord-006860-a3b8hyyr	3834	36	of	of	IN
cord-006860-a3b8hyyr	3834	37	values	value	NNS
cord-006860-a3b8hyyr	3834	38	(	(	-LRB-
cord-006860-a3b8hyyr	3834	39	p	p	NN
cord-006860-a3b8hyyr	3834	40	=	=	SYM
cord-006860-a3b8hyyr	3834	41	.086	.086	NFP
cord-006860-a3b8hyyr	3834	42	)	)	-RRB-
cord-006860-a3b8hyyr	3834	43	.	.	.
cord-006860-a3b8hyyr	3835	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3835	2	observed	observe	VBD
cord-006860-a3b8hyyr	3835	3	similar	similar	JJ
cord-006860-a3b8hyyr	3835	4	changes	change	NNS
cord-006860-a3b8hyyr	3835	5	in	in	IN
cord-006860-a3b8hyyr	3835	6	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3835	7	monomers	monomer	NNS
cord-006860-a3b8hyyr	3835	8	and	and	CC
cord-006860-a3b8hyyr	3835	9	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3835	10	fragments	fragment	NNS
cord-006860-a3b8hyyr	3835	11	Fl+2	Fl+2	NNS
cord-006860-a3b8hyyr	3835	12	.	.	.
cord-006860-a3b8hyyr	3836	1	From	from	IN
cord-006860-a3b8hyyr	3836	2	other	other	JJ
cord-006860-a3b8hyyr	3836	3	investigations	investigation	NNS
cord-006860-a3b8hyyr	3836	4	on	on	IN
cord-006860-a3b8hyyr	3836	5	the	the	DT
cord-006860-a3b8hyyr	3836	6	kinetics	kinetic	NNS
cord-006860-a3b8hyyr	3836	7	of	of	IN
cord-006860-a3b8hyyr	3836	8	the	the	DT
cord-006860-a3b8hyyr	3836	9	activation	activation	NN
cord-006860-a3b8hyyr	3836	10	of	of	IN
cord-006860-a3b8hyyr	3836	11	the	the	DT
cord-006860-a3b8hyyr	3836	12	procoagulatory	procoagulatory	NN
cord-006860-a3b8hyyr	3836	13	system	system	NN
cord-006860-a3b8hyyr	3836	14	we	-PRON-	PRP
cord-006860-a3b8hyyr	3836	15	know	know	VBP
cord-006860-a3b8hyyr	3836	16	that	that	IN
cord-006860-a3b8hyyr	3836	17	maximum	maximum	JJ
cord-006860-a3b8hyyr	3836	18	activil7	activil7	NN
cord-006860-a3b8hyyr	3836	19	is	be	VBZ
cord-006860-a3b8hyyr	3836	20	not	not	RB
cord-006860-a3b8hyyr	3836	21	reached	reach	VBN
cord-006860-a3b8hyyr	3836	22	until	until	IN
cord-006860-a3b8hyyr	3836	23	24	24	CD
cord-006860-a3b8hyyr	3836	24	hours	hour	NNS
cord-006860-a3b8hyyr	3836	25	after	after	IN
cord-006860-a3b8hyyr	3836	26	initiation	initiation	NN
cord-006860-a3b8hyyr	3836	27	of	of	IN
cord-006860-a3b8hyyr	3836	28	activation	activation	NN
cord-006860-a3b8hyyr	3836	29	.	.	.
cord-006860-a3b8hyyr	3837	1	These	these	DT
cord-006860-a3b8hyyr	3837	2	investigations	investigation	NNS
cord-006860-a3b8hyyr	3837	3	studied	study	VBD
cord-006860-a3b8hyyr	3837	4	perioperative	perioperative	JJ
cord-006860-a3b8hyyr	3837	5	changes	change	NNS
cord-006860-a3b8hyyr	3837	6	in	in	IN
cord-006860-a3b8hyyr	3837	7	different	different	JJ
cord-006860-a3b8hyyr	3837	8	kind	kind	NN
cord-006860-a3b8hyyr	3837	9	of	of	IN
cord-006860-a3b8hyyr	3837	10	operations	operation	NNS
cord-006860-a3b8hyyr	3837	11	which	which	WDT
cord-006860-a3b8hyyr	3837	12	served	serve	VBD
cord-006860-a3b8hyyr	3837	13	as	as	IN
cord-006860-a3b8hyyr	3837	14	a	a	DT
cord-006860-a3b8hyyr	3837	15	control	control	NN
cord-006860-a3b8hyyr	3837	16	group	group	NN
cord-006860-a3b8hyyr	3837	17	concerning	concern	VBG
cord-006860-a3b8hyyr	3837	18	the	the	DT
cord-006860-a3b8hyyr	3837	19	degrees	degree	NNS
cord-006860-a3b8hyyr	3837	20	of	of	IN
cord-006860-a3b8hyyr	3837	21	tissue	tissue	NN
cord-006860-a3b8hyyr	3837	22	damage	damage	NN
cord-006860-a3b8hyyr	3837	23	and	and	CC
cord-006860-a3b8hyyr	3837	24	resulting	result	VBG
cord-006860-a3b8hyyr	3837	25	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3837	26	disturbances	disturbance	NNS
cord-006860-a3b8hyyr	3837	27	.	.	.
cord-006860-a3b8hyyr	3838	1	To	to	TO
cord-006860-a3b8hyyr	3838	2	better	well	RBR
cord-006860-a3b8hyyr	3838	3	understand	understand	VB
cord-006860-a3b8hyyr	3838	4	these	these	DT
cord-006860-a3b8hyyr	3838	5	phenomena	phenomenon	NNS
cord-006860-a3b8hyyr	3838	6	we	-PRON-	PRP
cord-006860-a3b8hyyr	3838	7	plan	plan	VBP
cord-006860-a3b8hyyr	3838	8	to	to	TO
cord-006860-a3b8hyyr	3838	9	induce	induce	VB
cord-006860-a3b8hyyr	3838	10	mental	mental	JJ
cord-006860-a3b8hyyr	3838	11	stress	stress	NN
cord-006860-a3b8hyyr	3838	12	in	in	IN
cord-006860-a3b8hyyr	3838	13	a	a	DT
cord-006860-a3b8hyyr	3838	14	laboratoq	laboratoq	NNP
cord-006860-a3b8hyyr	3838	15	'	'	POS
cord-006860-a3b8hyyr	3838	16	environment	environment	NN
cord-006860-a3b8hyyr	3838	17	to	to	TO
cord-006860-a3b8hyyr	3838	18	further	further	RB
cord-006860-a3b8hyyr	3838	19	exclude	exclude	VB
cord-006860-a3b8hyyr	3838	20	unknow	unknow	JJ
cord-006860-a3b8hyyr	3838	21	~	~	NFP
cord-006860-a3b8hyyr	3838	22	a	a	DT
cord-006860-a3b8hyyr	3838	23	influences	influence	NNS
cord-006860-a3b8hyyr	3838	24	on	on	IN
cord-006860-a3b8hyyr	3838	25	the	the	DT
cord-006860-a3b8hyyr	3838	26	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	3838	27	which	which	WDT
cord-006860-a3b8hyyr	3838	28	can	can	MD
cord-006860-a3b8hyyr	3838	29	activate	activate	VB
cord-006860-a3b8hyyr	3838	30	the	the	DT
cord-006860-a3b8hyyr	3838	31	procoagulatory	procoagulatory	NN
cord-006860-a3b8hyyr	3838	32	and	and	CC
cord-006860-a3b8hyyr	3838	33	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	3838	34	systems	system	NNS
cord-006860-a3b8hyyr	3838	35	.	.	.
cord-006860-a3b8hyyr	3839	1	TRIODENA	TRIODENA	NNP
cord-006860-a3b8hyyr	3839	2	(	(	-LRB-
cord-006860-a3b8hyyr	3839	3	T	T	NNP
cord-006860-a3b8hyyr	3839	4	)	)	-RRB-
cord-006860-a3b8hyyr	3840	1	30/40/30	30/40/30	CD
cord-006860-a3b8hyyr	3841	1	ug	ug	NNP
cord-006860-a3b8hyyr	3841	2	EE	EE	NNP
cord-006860-a3b8hyyr	3841	3	,	,	,
cord-006860-a3b8hyyr	3841	4	50/70/100	50/70/100	CD
cord-006860-a3b8hyyr	3841	5	ug	ug	NNP
cord-006860-a3b8hyyr	3841	6	gestodene	gestodene	NNP
cord-006860-a3b8hyyr	3841	7	)	)	-RRB-
cord-006860-a3b8hyyr	3841	8	were	be	VBD
cord-006860-a3b8hyyr	3841	9	tested	test	VBN
cord-006860-a3b8hyyr	3841	10	for	for	IN
cord-006860-a3b8hyyr	3841	11	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3841	12	effect	effect	NN
cord-006860-a3b8hyyr	3841	13	on	on	IN
cord-006860-a3b8hyyr	3841	14	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	3841	15	parameters	parameter	NNS
cord-006860-a3b8hyyr	3841	16	.	.	.
cord-006860-a3b8hyyr	3842	1	Three	three	CD
cord-006860-a3b8hyyr	3842	2	groups	group	NNS
cord-006860-a3b8hyyr	3842	3	(	(	-LRB-
cord-006860-a3b8hyyr	3842	4	n=20	n=20	NNP
cord-006860-a3b8hyyr	3842	5	)	)	-RRB-
cord-006860-a3b8hyyr	3842	6	of	of	IN
cord-006860-a3b8hyyr	3842	7	healthy	healthy	JJ
cord-006860-a3b8hyyr	3842	8	female	female	JJ
cord-006860-a3b8hyyr	3842	9	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	3842	10	were	be	VBD
cord-006860-a3b8hyyr	3842	11	treated	treat	VBN
cord-006860-a3b8hyyr	3842	12	for	for	IN
cord-006860-a3b8hyyr	3842	13	6	6	CD
cord-006860-a3b8hyyr	3842	14	months	month	NNS
cord-006860-a3b8hyyr	3842	15	with	with	IN
cord-006860-a3b8hyyr	3842	16	one	one	CD
cord-006860-a3b8hyyr	3842	17	of	of	IN
cord-006860-a3b8hyyr	3842	18	these	these	DT
cord-006860-a3b8hyyr	3842	19	OC	OC	NNP
cord-006860-a3b8hyyr	3842	20	.	.	.
cord-006860-a3b8hyyr	3843	1	Blood	blood	NN
cord-006860-a3b8hyyr	3843	2	was	be	VBD
cord-006860-a3b8hyyr	3843	3	taken	take	VBN
cord-006860-a3b8hyyr	3843	4	before	before	IN
cord-006860-a3b8hyyr	3843	5	treatment	treatment	NN
cord-006860-a3b8hyyr	3843	6	(	(	-LRB-
cord-006860-a3b8hyyr	3843	7	day	day	NN
cord-006860-a3b8hyyr	3843	8	24	24	CD
cord-006860-a3b8hyyr	3843	9	-	-	SYM
cord-006860-a3b8hyyr	3843	10	28	28	CD
cord-006860-a3b8hyyr	3843	11	of	of	IN
cord-006860-a3b8hyyr	3843	12	pretreatment	pretreatment	NN
cord-006860-a3b8hyyr	3843	13	cycle	cycle	NN
cord-006860-a3b8hyyr	3843	14	,	,	,
cord-006860-a3b8hyyr	3843	15	0	0	CD
cord-006860-a3b8hyyr	3843	16	)	)	-RRB-
cord-006860-a3b8hyyr	3843	17	and	and	CC
cord-006860-a3b8hyyr	3843	18	on	on	IN
cord-006860-a3b8hyyr	3843	19	days	day	NNS
cord-006860-a3b8hyyr	3843	20	18	18	CD
cord-006860-a3b8hyyr	3843	21	-	-	SYM
cord-006860-a3b8hyyr	3843	22	22	22	CD
cord-006860-a3b8hyyr	3843	23	of	of	IN
cord-006860-a3b8hyyr	3843	24	the	the	DT
cord-006860-a3b8hyyr	3843	25	3	3	CD
cord-006860-a3b8hyyr	3843	26	~	~	NFP
cord-006860-a3b8hyyr	3843	27	(	(	-LRB-
cord-006860-a3b8hyyr	3843	28	I	i	NN
cord-006860-a3b8hyyr	3843	29	)	)	-RRB-
cord-006860-a3b8hyyr	3843	30	and	and	CC
cord-006860-a3b8hyyr	3843	31	62	62	CD
cord-006860-a3b8hyyr	3843	32	(	(	-LRB-
cord-006860-a3b8hyyr	3843	33	II	II	NNP
cord-006860-a3b8hyyr	3843	34	)	)	-RRB-
cord-006860-a3b8hyyr	3843	35	treatment	treatment	NN
cord-006860-a3b8hyyr	3843	36	cycle	cycle	NN
cord-006860-a3b8hyyr	3843	37	.	.	.
cord-006860-a3b8hyyr	3844	1	Indications	indication	NNS
cord-006860-a3b8hyyr	3844	2	of	of	IN
cord-006860-a3b8hyyr	3844	3	an	an	DT
cord-006860-a3b8hyyr	3844	4	activation	activation	NN
cord-006860-a3b8hyyr	3844	5	of	of	IN
cord-006860-a3b8hyyr	3844	6	blood	blood	NN
cord-006860-a3b8hyyr	3844	7	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3844	8	and	and	CC
cord-006860-a3b8hyyr	3844	9	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	3844	10	were	be	VBD
cord-006860-a3b8hyyr	3844	11	detected	detect	VBN
cord-006860-a3b8hyyr	3844	12	as	as	IN
cord-006860-a3b8hyyr	3844	13	the	the	DT
cord-006860-a3b8hyyr	3844	14	plasma	plasma	NN
cord-006860-a3b8hyyr	3844	15	levels	level	NNS
cord-006860-a3b8hyyr	3844	16	of	of	IN
cord-006860-a3b8hyyr	3844	17	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3844	18	fragment	fragment	NN
cord-006860-a3b8hyyr	3844	19	F	F	NNP
cord-006860-a3b8hyyr	3844	20	I+2	I+2	NNP
cord-006860-a3b8hyyr	3844	21	and	and	CC
cord-006860-a3b8hyyr	3844	22	of	of	IN
cord-006860-a3b8hyyr	3844	23	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3844	24	split	split	NN
cord-006860-a3b8hyyr	3844	25	product	product	NN
cord-006860-a3b8hyyr	3844	26	D	D	NNP
cord-006860-a3b8hyyr	3844	27	-	-	HYPH
cord-006860-a3b8hyyr	3844	28	Dimer	Dimer	NNP
cord-006860-a3b8hyyr	3844	29	and	and	CC
cord-006860-a3b8hyyr	3845	1	plasmin	plasmin	NNP
cord-006860-a3b8hyyr	3845	2	antiplasmin	antiplasmin	NNP
cord-006860-a3b8hyyr	3845	3	complexes	complex	NNS
cord-006860-a3b8hyyr	3845	4	were	be	VBD
cord-006860-a3b8hyyr	3845	5	found	find	VBN
cord-006860-a3b8hyyr	3845	6	elevated	elevate	VBN
cord-006860-a3b8hyyr	3845	7	during	during	IN
cord-006860-a3b8hyyr	3845	8	treatment	treatment	NN
cord-006860-a3b8hyyr	3845	9	.	.	.
cord-006860-a3b8hyyr	3846	1	The	the	DT
cord-006860-a3b8hyyr	3846	2	following	follow	VBG
cord-006860-a3b8hyyr	3846	3	main	main	JJ
cord-006860-a3b8hyyr	3846	4	regulatory	regulatory	JJ
cord-006860-a3b8hyyr	3846	5	components	component	NNS
cord-006860-a3b8hyyr	3846	6	of	of	IN
cord-006860-a3b8hyyr	3846	7	blood	blood	NN
cord-006860-a3b8hyyr	3846	8	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3846	9	,	,	,
cord-006860-a3b8hyyr	3846	10	activators	activator	NNS
cord-006860-a3b8hyyr	3846	11	and	and	CC
cord-006860-a3b8hyyr	3846	12	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3846	13	,	,	,
cord-006860-a3b8hyyr	3846	14	were	be	VBD
cord-006860-a3b8hyyr	3846	15	investigated	investigate	VBN
cord-006860-a3b8hyyr	3846	16	:	:	:
cord-006860-a3b8hyyr	3847	1	factor	factor	NNP
cord-006860-a3b8hyyr	3847	2	VII	VII	NNP
cord-006860-a3b8hyyr	3847	3	antigen	antigen	NN
cord-006860-a3b8hyyr	3847	4	FVIIAg	FVIIAg	NNS
cord-006860-a3b8hyyr	3847	5	,	,	,
cord-006860-a3b8hyyr	3847	6	FVII	FVII	NNP
cord-006860-a3b8hyyr	3847	7	clotting	clotting	NN
cord-006860-a3b8hyyr	3847	8	activity	activity	NN
cord-006860-a3b8hyyr	3847	9	FVIIe	FVIIe	NNS
cord-006860-a3b8hyyr	3847	10	,	,	,
cord-006860-a3b8hyyr	3847	11	circulating	circulate	VBG
cord-006860-a3b8hyyr	3847	12	activated	activate	VBN
cord-006860-a3b8hyyr	3847	13	factor	factor	NN
cord-006860-a3b8hyyr	3847	14	VII	VII	NNP
cord-006860-a3b8hyyr	3847	15	cFVIIa	cFVIIa	NNP
cord-006860-a3b8hyyr	3847	16	and	and	CC
cord-006860-a3b8hyyr	3847	17	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3847	18	3	3	CD
cord-006860-a3b8hyyr	3847	19	AT3	at3	NN
cord-006860-a3b8hyyr	3847	20	activity	activity	NN
cord-006860-a3b8hyyr	3847	21	,	,	,
cord-006860-a3b8hyyr	3847	22	total	total	JJ
cord-006860-a3b8hyyr	3847	23	protein	protein	NN
cord-006860-a3b8hyyr	3847	24	S	S	NNP
cord-006860-a3b8hyyr	3847	25	antigen	antigen	NN
cord-006860-a3b8hyyr	3847	26	tPS	tPS	NNP
cord-006860-a3b8hyyr	3847	27	-	-	HYPH
cord-006860-a3b8hyyr	3847	28	Ag	Ag	NNP
cord-006860-a3b8hyyr	3847	29	,	,	,
cord-006860-a3b8hyyr	3847	30	free	free	JJ
cord-006860-a3b8hyyr	3847	31	protein	protein	NN
cord-006860-a3b8hyyr	3847	32	S	S	NNP
cord-006860-a3b8hyyr	3847	33	antigen	antigen	NN
cord-006860-a3b8hyyr	3847	34	fPS	fPS	NNP
cord-006860-a3b8hyyr	3847	35	-	-	HYPH
cord-006860-a3b8hyyr	3847	36	Ag	Ag	NNP
cord-006860-a3b8hyyr	3847	37	,	,	,
cord-006860-a3b8hyyr	3847	38	protein	protein	NN
cord-006860-a3b8hyyr	3847	39	S	S	NNP
cord-006860-a3b8hyyr	3847	40	activity	activity	NN
cord-006860-a3b8hyyr	3847	41	PSact	PSact	NNP
cord-006860-a3b8hyyr	3847	42	,	,	,
cord-006860-a3b8hyyr	3847	43	circulating	circulate	VBG
cord-006860-a3b8hyyr	3847	44	thrombomodulin	thrombomodulin	NNP
cord-006860-a3b8hyyr	3847	45	eTM	eTM	,
cord-006860-a3b8hyyr	3847	46	FVIIAg	fviiag	XX
cord-006860-a3b8hyyr	3847	47	,	,	,
cord-006860-a3b8hyyr	3847	48	FVIIe	FVIIe	NNPS
cord-006860-a3b8hyyr	3847	49	and	and	CC
cord-006860-a3b8hyyr	3847	50	cFVIIa	cFVIIa	NNP
cord-006860-a3b8hyyr	3847	51	significantly	significantly	RB
cord-006860-a3b8hyyr	3847	52	increased	increase	VBN
cord-006860-a3b8hyyr	3847	53	during	during	IN
cord-006860-a3b8hyyr	3847	54	treatment	treatment	NN
cord-006860-a3b8hyyr	3847	55	;	;	:
cord-006860-a3b8hyyr	3847	56	cFVIIa	cfviia	NN
cord-006860-a3b8hyyr	3847	57	:	:	:
cord-006860-a3b8hyyr	3847	58	0	0	CD
cord-006860-a3b8hyyr	3847	59	:	:	:
cord-006860-a3b8hyyr	3848	1	C	C	NNP
cord-006860-a3b8hyyr	3848	2	32.4	32.4	CD
cord-006860-a3b8hyyr	3848	3	mU	mU	NNP
cord-006860-a3b8hyyr	3848	4	/	/	SYM
cord-006860-a3b8hyyr	3848	5	ml	ml	NN
cord-006860-a3b8hyyr	3849	1	A	a	DT
cord-006860-a3b8hyyr	3849	2	prethrombotic	prethrombotic	JJ
cord-006860-a3b8hyyr	3849	3	condition	condition	NN
cord-006860-a3b8hyyr	3849	4	characterized	characterize	VBN
cord-006860-a3b8hyyr	3849	5	by	by	IN
cord-006860-a3b8hyyr	3849	6	elevated	elevated	JJ
cord-006860-a3b8hyyr	3849	7	levels	level	NNS
cord-006860-a3b8hyyr	3849	8	of	of	IN
cord-006860-a3b8hyyr	3849	9	circulating	circulate	VBG
cord-006860-a3b8hyyr	3849	10	soluble	soluble	JJ
cord-006860-a3b8hyyr	3849	11	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3849	12	has	have	VBZ
cord-006860-a3b8hyyr	3849	13	been	be	VBN
cord-006860-a3b8hyyr	3849	14	claimed	claim	VBN
cord-006860-a3b8hyyr	3849	15	to	to	TO
cord-006860-a3b8hyyr	3849	16	be	be	VB
cord-006860-a3b8hyyr	3849	17	a	a	DT
cord-006860-a3b8hyyr	3849	18	predisposing	predisposing	JJ
cord-006860-a3b8hyyr	3849	19	factor	factor	NN
cord-006860-a3b8hyyr	3849	20	for	for	IN
cord-006860-a3b8hyyr	3849	21	accumulation	accumulation	NN
cord-006860-a3b8hyyr	3849	22	of	of	IN
cord-006860-a3b8hyyr	3849	23	coronary	coronary	JJ
cord-006860-a3b8hyyr	3849	24	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	3849	25	material	material	NN
cord-006860-a3b8hyyr	3849	26	in	in	IN
cord-006860-a3b8hyyr	3849	27	acute	acute	JJ
cord-006860-a3b8hyyr	3849	28	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	3849	29	infarction	infarction	NN
cord-006860-a3b8hyyr	3849	30	.	.	.
cord-006860-a3b8hyyr	3850	1	The	the	DT
cord-006860-a3b8hyyr	3850	2	present	present	JJ
cord-006860-a3b8hyyr	3850	3	study	study	NN
cord-006860-a3b8hyyr	3850	4	includes	include	VBZ
cord-006860-a3b8hyyr	3850	5	161	161	CD
cord-006860-a3b8hyyr	3850	6	patients	patient	NNS
cord-006860-a3b8hyyr	3850	7	with	with	IN
cord-006860-a3b8hyyr	3850	8	clinical	clinical	JJ
cord-006860-a3b8hyyr	3850	9	suspicion	suspicion	NN
cord-006860-a3b8hyyr	3850	10	of	of	IN
cord-006860-a3b8hyyr	3850	11	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	3850	12	infarction	infarction	NN
cord-006860-a3b8hyyr	3850	13	.	.	.
cord-006860-a3b8hyyr	3851	1	Blood	blood	NN
cord-006860-a3b8hyyr	3851	2	samples	sample	NNS
cord-006860-a3b8hyyr	3851	3	were	be	VBD
cord-006860-a3b8hyyr	3851	4	drawn	draw	VBN
cord-006860-a3b8hyyr	3851	5	by	by	IN
cord-006860-a3b8hyyr	3851	6	the	the	DT
cord-006860-a3b8hyyr	3851	7	primary	primary	JJ
cord-006860-a3b8hyyr	3851	8	care	care	NN
cord-006860-a3b8hyyr	3851	9	physician	physician	NN
cord-006860-a3b8hyyr	3851	10	,	,	,
cord-006860-a3b8hyyr	3851	11	upon	upon	IN
cord-006860-a3b8hyyr	3851	12	arrival	arrival	NN
cord-006860-a3b8hyyr	3851	13	in	in	IN
cord-006860-a3b8hyyr	3851	14	the	the	DT
cord-006860-a3b8hyyr	3851	15	hospital	hospital	NN
cord-006860-a3b8hyyr	3851	16	,	,	,
cord-006860-a3b8hyyr	3851	17	and	and	CC
cord-006860-a3b8hyyr	3851	18	after	after	IN
cord-006860-a3b8hyyr	3851	19	2	2	CD
cord-006860-a3b8hyyr	3851	20	,	,	,
cord-006860-a3b8hyyr	3851	21	6	6	CD
cord-006860-a3b8hyyr	3851	22	,	,	,
cord-006860-a3b8hyyr	3851	23	12	12	CD
cord-006860-a3b8hyyr	3851	24	,	,	,
cord-006860-a3b8hyyr	3851	25	and	and	CC
cord-006860-a3b8hyyr	3851	26	24	24	CD
cord-006860-a3b8hyyr	3851	27	hours	hour	NNS
cord-006860-a3b8hyyr	3851	28	of	of	IN
cord-006860-a3b8hyyr	3851	29	hospital	hospital	NN
cord-006860-a3b8hyyr	3851	30	stay	stay	NN
cord-006860-a3b8hyyr	3851	31	.	.	.
cord-006860-a3b8hyyr	3852	1	Patients	patient	NNS
cord-006860-a3b8hyyr	3852	2	with	with	IN
cord-006860-a3b8hyyr	3852	3	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	3852	4	infarction	infarction	NN
cord-006860-a3b8hyyr	3852	5	were	be	VBD
cord-006860-a3b8hyyr	3852	6	identified	identify	VBN
cord-006860-a3b8hyyr	3852	7	by	by	IN
cord-006860-a3b8hyyr	3852	8	typical	typical	JJ
cord-006860-a3b8hyyr	3852	9	course	course	NN
cord-006860-a3b8hyyr	3852	10	in	in	IN
cord-006860-a3b8hyyr	3852	11	12	12	CD
cord-006860-a3b8hyyr	3852	12	lead	lead	NN
cord-006860-a3b8hyyr	3852	13	ECG	ECG	NNP
cord-006860-a3b8hyyr	3852	14	,	,	,
cord-006860-a3b8hyyr	3852	15	and	and	CC
cord-006860-a3b8hyyr	3852	16	upon	upon	IN
cord-006860-a3b8hyyr	3852	17	sequential	sequential	JJ
cord-006860-a3b8hyyr	3852	18	determination	determination	NN
cord-006860-a3b8hyyr	3852	19	of	of	IN
cord-006860-a3b8hyyr	3852	20	troponine	troponine	NNP
cord-006860-a3b8hyyr	3852	21	T	T	NNP
cord-006860-a3b8hyyr	3852	22	,	,	,
cord-006860-a3b8hyyr	3852	23	myoglobin	myoglobin	NN
cord-006860-a3b8hyyr	3852	24	,	,	,
cord-006860-a3b8hyyr	3852	25	CK	CK	NNP
cord-006860-a3b8hyyr	3852	26	,	,	,
cord-006860-a3b8hyyr	3852	27	and	and	CC
cord-006860-a3b8hyyr	3852	28	CK	CK	NNP
cord-006860-a3b8hyyr	3852	29	-	-	HYPH
cord-006860-a3b8hyyr	3852	30	MB	MB	NNP
cord-006860-a3b8hyyr	3852	31	.	.	.
cord-006860-a3b8hyyr	3853	1	Patients	patient	NNS
cord-006860-a3b8hyyr	3853	2	with	with	IN
cord-006860-a3b8hyyr	3853	3	primary	primary	JJ
cord-006860-a3b8hyyr	3853	4	CPR	CPR	NNP
cord-006860-a3b8hyyr	3853	5	were	be	VBD
cord-006860-a3b8hyyr	3853	6	excluded	exclude	VBN
cord-006860-a3b8hyyr	3853	7	from	from	IN
cord-006860-a3b8hyyr	3853	8	evaluation	evaluation	NN
cord-006860-a3b8hyyr	3853	9	.	.	.
cord-006860-a3b8hyyr	3854	1	Soluble	soluble	JJ
cord-006860-a3b8hyyr	3854	2	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3854	3	was	be	VBD
cord-006860-a3b8hyyr	3854	4	measured	measure	VBN
cord-006860-a3b8hyyr	3854	5	by	by	IN
cord-006860-a3b8hyyr	3854	6	Enzymun	Enzymun	NNP
cord-006860-a3b8hyyr	3855	1	®	®	,
cord-006860-a3b8hyyr	3855	2	-Test	-Test	.
cord-006860-a3b8hyyr	3856	1	FM	FM	NNP
cord-006860-a3b8hyyr	3857	1	(	(	-LRB-
cord-006860-a3b8hyyr	3857	2	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	3857	3	Mannheim	Mannheim	NNP
cord-006860-a3b8hyyr	3857	4	)	)	-RRB-
cord-006860-a3b8hyyr	3857	5	.	.	.
cord-006860-a3b8hyyr	3858	1	Patients	patient	NNS
cord-006860-a3b8hyyr	3858	2	with	with	IN
cord-006860-a3b8hyyr	3858	3	acute	acute	JJ
cord-006860-a3b8hyyr	3858	4	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	3858	5	infarction	infarction	NN
cord-006860-a3b8hyyr	3858	6	display	display	NN
cord-006860-a3b8hyyr	3858	7	soluble	soluble	JJ
cord-006860-a3b8hyyr	3858	8	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3858	9	levels	level	NNS
cord-006860-a3b8hyyr	3858	10	within	within	IN
cord-006860-a3b8hyyr	3858	11	the	the	DT
cord-006860-a3b8hyyr	3858	12	normal	normal	JJ
cord-006860-a3b8hyyr	3858	13	range	range	NN
cord-006860-a3b8hyyr	3858	14	(	(	-LRB-
cord-006860-a3b8hyyr	3858	15	<	<	XX
cord-006860-a3b8hyyr	3858	16	5	5	CD
cord-006860-a3b8hyyr	3858	17	~tg	~tg	NNS
cord-006860-a3b8hyyr	3858	18	/	/	SYM
cord-006860-a3b8hyyr	3858	19	ml	ml	NN
cord-006860-a3b8hyyr	3858	20	)	)	-RRB-
cord-006860-a3b8hyyr	3858	21	during	during	IN
cord-006860-a3b8hyyr	3858	22	the	the	DT
cord-006860-a3b8hyyr	3858	23	initial	initial	JJ
cord-006860-a3b8hyyr	3858	24	two	two	CD
cord-006860-a3b8hyyr	3858	25	hours	hour	NNS
cord-006860-a3b8hyyr	3858	26	after	after	IN
cord-006860-a3b8hyyr	3858	27	onset	onset	NN
cord-006860-a3b8hyyr	3858	28	of	of	IN
cord-006860-a3b8hyyr	3858	29	symptoms	symptom	NNS
cord-006860-a3b8hyyr	3858	30	.	.	.
cord-006860-a3b8hyyr	3859	1	There	there	EX
cord-006860-a3b8hyyr	3859	2	was	be	VBD
cord-006860-a3b8hyyr	3859	3	no	no	DT
cord-006860-a3b8hyyr	3859	4	significant	significant	JJ
cord-006860-a3b8hyyr	3859	5	difference	difference	NN
cord-006860-a3b8hyyr	3859	6	between	between	IN
cord-006860-a3b8hyyr	3859	7	patients	patient	NNS
cord-006860-a3b8hyyr	3859	8	with	with	IN
cord-006860-a3b8hyyr	3859	9	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	3859	10	infarction	infarction	NN
cord-006860-a3b8hyyr	3859	11	and	and	CC
cord-006860-a3b8hyyr	3859	12	patients	patient	NNS
cord-006860-a3b8hyyr	3859	13	with	with	IN
cord-006860-a3b8hyyr	3859	14	coronary	coronary	JJ
cord-006860-a3b8hyyr	3859	15	heart	heart	NN
cord-006860-a3b8hyyr	3859	16	disease	disease	NN
cord-006860-a3b8hyyr	3859	17	without	without	IN
cord-006860-a3b8hyyr	3859	18	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	3859	19	infarction	infarction	NN
cord-006860-a3b8hyyr	3859	20	.	.	.
cord-006860-a3b8hyyr	3860	1	Slightly	slightly	RB
cord-006860-a3b8hyyr	3860	2	elevated	elevated	JJ
cord-006860-a3b8hyyr	3860	3	levels	level	NNS
cord-006860-a3b8hyyr	3860	4	were	be	VBD
cord-006860-a3b8hyyr	3860	5	found	find	VBN
cord-006860-a3b8hyyr	3860	6	in	in	IN
cord-006860-a3b8hyyr	3860	7	patients	patient	NNS
cord-006860-a3b8hyyr	3860	8	with	with	IN
cord-006860-a3b8hyyr	3860	9	atrial	atrial	JJ
cord-006860-a3b8hyyr	3860	10	fibrillation	fibrillation	NN
cord-006860-a3b8hyyr	3860	11	,	,	,
cord-006860-a3b8hyyr	3860	12	reflecting	reflect	VBG
cord-006860-a3b8hyyr	3860	13	intracardiac	intracardiac	NNP
cord-006860-a3b8hyyr	3860	14	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3860	15	formation	formation	NN
cord-006860-a3b8hyyr	3860	16	.	.	.
cord-006860-a3b8hyyr	3861	1	In	in	IN
cord-006860-a3b8hyyr	3861	2	patients	patient	NNS
cord-006860-a3b8hyyr	3861	3	without	without	IN
cord-006860-a3b8hyyr	3861	4	fibrinolytie	fibrinolytie	NN
cord-006860-a3b8hyyr	3861	5	treatment	treatment	NN
cord-006860-a3b8hyyr	3861	6	,	,	,
cord-006860-a3b8hyyr	3861	7	a	a	DT
cord-006860-a3b8hyyr	3861	8	slight	slight	JJ
cord-006860-a3b8hyyr	3861	9	increase	increase	NN
cord-006860-a3b8hyyr	3861	10	of	of	IN
cord-006860-a3b8hyyr	3861	11	soluble	soluble	JJ
cord-006860-a3b8hyyr	3861	12	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3861	13	levels	level	NNS
cord-006860-a3b8hyyr	3861	14	with	with	IN
cord-006860-a3b8hyyr	3861	15	a	a	DT
cord-006860-a3b8hyyr	3861	16	maximum	maximum	NN
cord-006860-a3b8hyyr	3861	17	after	after	IN
cord-006860-a3b8hyyr	3861	18	approximately	approximately	RB
cord-006860-a3b8hyyr	3861	19	8	8	CD
cord-006860-a3b8hyyr	3861	20	hours	hour	NNS
cord-006860-a3b8hyyr	3861	21	is	be	VBZ
cord-006860-a3b8hyyr	3861	22	observed	observe	VBN
cord-006860-a3b8hyyr	3861	23	.	.	.
cord-006860-a3b8hyyr	3862	1	Most	Most	JJS
cord-006860-a3b8hyyr	3862	2	patients	patient	NNS
cord-006860-a3b8hyyr	3862	3	with	with	IN
cord-006860-a3b8hyyr	3862	4	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	3862	5	treatment	treatment	NN
cord-006860-a3b8hyyr	3862	6	display	display	NN
cord-006860-a3b8hyyr	3862	7	a	a	DT
cord-006860-a3b8hyyr	3862	8	considerable	considerable	JJ
cord-006860-a3b8hyyr	3862	9	increase	increase	NN
cord-006860-a3b8hyyr	3862	10	in	in	IN
cord-006860-a3b8hyyr	3862	11	soluble	soluble	JJ
cord-006860-a3b8hyyr	3862	12	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3862	13	,	,	,
cord-006860-a3b8hyyr	3862	14	with	with	IN
cord-006860-a3b8hyyr	3862	15	maximum	maximum	JJ
cord-006860-a3b8hyyr	3862	16	levels	level	NNS
cord-006860-a3b8hyyr	3862	17	immediately	immediately	RB
cord-006860-a3b8hyyr	3862	18	after	after	IN
cord-006860-a3b8hyyr	3862	19	infusion	infusion	NN
cord-006860-a3b8hyyr	3862	20	of	of	IN
cord-006860-a3b8hyyr	3862	21	the	the	DT
cord-006860-a3b8hyyr	3862	22	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	3862	23	agent	agent	NN
cord-006860-a3b8hyyr	3862	24	.	.	.
cord-006860-a3b8hyyr	3863	1	Four	four	CD
cord-006860-a3b8hyyr	3863	2	patients	patient	NNS
cord-006860-a3b8hyyr	3863	3	with	with	IN
cord-006860-a3b8hyyr	3863	4	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	3863	5	embolism	embolism	NN
cord-006860-a3b8hyyr	3863	6	showed	show	VBD
cord-006860-a3b8hyyr	3863	7	soluble	soluble	JJ
cord-006860-a3b8hyyr	3863	8	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3863	9	levels	level	NNS
cord-006860-a3b8hyyr	3863	10	in	in	IN
cord-006860-a3b8hyyr	3863	11	the	the	DT
cord-006860-a3b8hyyr	3863	12	range	range	NN
cord-006860-a3b8hyyr	3863	13	of	of	IN
cord-006860-a3b8hyyr	3863	14	40	40	CD
cord-006860-a3b8hyyr	3863	15	-	-	SYM
cord-006860-a3b8hyyr	3863	16	300	300	CD
cord-006860-a3b8hyyr	3863	17	[	[	-LRB-
cord-006860-a3b8hyyr	3863	18	.tg	.tg	NNP
cord-006860-a3b8hyyr	3863	19	/	/	SYM
cord-006860-a3b8hyyr	3863	20	ml	ml	NNS
cord-006860-a3b8hyyr	3863	21	,	,	,
cord-006860-a3b8hyyr	3863	22	which	which	WDT
cord-006860-a3b8hyyr	3863	23	remained	remain	VBD
cord-006860-a3b8hyyr	3863	24	in	in	IN
cord-006860-a3b8hyyr	3863	25	the	the	DT
cord-006860-a3b8hyyr	3863	26	same	same	JJ
cord-006860-a3b8hyyr	3863	27	range	range	NN
cord-006860-a3b8hyyr	3863	28	during	during	IN
cord-006860-a3b8hyyr	3863	29	the	the	DT
cord-006860-a3b8hyyr	3863	30	entire	entire	JJ
cord-006860-a3b8hyyr	3863	31	observation	observation	NN
cord-006860-a3b8hyyr	3863	32	period	period	NN
cord-006860-a3b8hyyr	3863	33	.	.	.
cord-006860-a3b8hyyr	3864	1	In	in	IN
cord-006860-a3b8hyyr	3864	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	3864	3	,	,	,
cord-006860-a3b8hyyr	3864	4	circulating	circulate	VBG
cord-006860-a3b8hyyr	3864	5	soluble	soluble	JJ
cord-006860-a3b8hyyr	3864	6	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3864	7	is	be	VBZ
cord-006860-a3b8hyyr	3864	8	not	not	RB
cord-006860-a3b8hyyr	3864	9	increased	increase	VBN
cord-006860-a3b8hyyr	3864	10	in	in	IN
cord-006860-a3b8hyyr	3864	11	patients	patient	NNS
cord-006860-a3b8hyyr	3864	12	with	with	IN
cord-006860-a3b8hyyr	3864	13	acute	acute	JJ
cord-006860-a3b8hyyr	3864	14	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	3864	15	infarction	infarction	NN
cord-006860-a3b8hyyr	3864	16	and	and	CC
cord-006860-a3b8hyyr	3864	17	does	do	VBZ
cord-006860-a3b8hyyr	3864	18	not	not	RB
cord-006860-a3b8hyyr	3864	19	appear	appear	VB
cord-006860-a3b8hyyr	3864	20	to	to	TO
cord-006860-a3b8hyyr	3864	21	be	be	VB
cord-006860-a3b8hyyr	3864	22	a	a	DT
cord-006860-a3b8hyyr	3864	23	predictor	predictor	NN
cord-006860-a3b8hyyr	3864	24	of	of	IN
cord-006860-a3b8hyyr	3864	25	acute	acute	JJ
cord-006860-a3b8hyyr	3864	26	coronary	coronary	JJ
cord-006860-a3b8hyyr	3864	27	events	event	NNS
cord-006860-a3b8hyyr	3864	28	.	.	.
cord-006860-a3b8hyyr	3865	1	High	high	JJ
cord-006860-a3b8hyyr	3865	2	levels	level	NNS
cord-006860-a3b8hyyr	3865	3	of	of	IN
cord-006860-a3b8hyyr	3865	4	soluble	soluble	JJ
cord-006860-a3b8hyyr	3865	5	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3865	6	in	in	IN
cord-006860-a3b8hyyr	3865	7	patients	patient	NNS
cord-006860-a3b8hyyr	3865	8	with	with	IN
cord-006860-a3b8hyyr	3865	9	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	3865	10	therapy	therapy	NN
cord-006860-a3b8hyyr	3865	11	may	may	MD
cord-006860-a3b8hyyr	3865	12	reflect	reflect	VB
cord-006860-a3b8hyyr	3865	13	release	release	NN
cord-006860-a3b8hyyr	3865	14	of	of	IN
cord-006860-a3b8hyyr	3865	15	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3865	16	from	from	IN
cord-006860-a3b8hyyr	3865	17	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	3865	18	material	material	NN
cord-006860-a3b8hyyr	3865	19	,	,	,
cord-006860-a3b8hyyr	3865	20	but	but	CC
cord-006860-a3b8hyyr	3865	21	also	also	RB
cord-006860-a3b8hyyr	3865	22	de	de	IN
cord-006860-a3b8hyyr	3865	23	novo	novo	NNP
cord-006860-a3b8hyyr	3865	24	generation	generation	NN
cord-006860-a3b8hyyr	3865	25	of	of	IN
cord-006860-a3b8hyyr	3865	26	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3865	27	due	due	IN
cord-006860-a3b8hyyr	3865	28	to	to	IN
cord-006860-a3b8hyyr	3865	29	release	release	NN
cord-006860-a3b8hyyr	3865	30	of	of	IN
cord-006860-a3b8hyyr	3865	31	active	active	JJ
cord-006860-a3b8hyyr	3865	32	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3865	33	from	from	IN
cord-006860-a3b8hyyr	3865	34	thrombi	thrombi	NNP
cord-006860-a3b8hyyr	3865	35	not	not	RB
cord-006860-a3b8hyyr	3865	36	necessarily	necessarily	RB
cord-006860-a3b8hyyr	3865	37	located	locate	VBN
cord-006860-a3b8hyyr	3865	38	in	in	IN
cord-006860-a3b8hyyr	3865	39	the	the	DT
cord-006860-a3b8hyyr	3865	40	coronary	coronary	JJ
cord-006860-a3b8hyyr	3865	41	vessels	vessel	NNS
cord-006860-a3b8hyyr	3865	42	.	.	.
cord-006860-a3b8hyyr	3866	1	Detection	detection	NN
cord-006860-a3b8hyyr	3866	2	of	of	IN
cord-006860-a3b8hyyr	3866	3	elevated	elevated	JJ
cord-006860-a3b8hyyr	3866	4	levels	level	NNS
cord-006860-a3b8hyyr	3866	5	of	of	IN
cord-006860-a3b8hyyr	3866	6	soluble	soluble	JJ
cord-006860-a3b8hyyr	3866	7	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3866	8	in	in	IN
cord-006860-a3b8hyyr	3866	9	patients	patient	NNS
cord-006860-a3b8hyyr	3866	10	with	with	IN
cord-006860-a3b8hyyr	3866	11	acute	acute	JJ
cord-006860-a3b8hyyr	3866	12	chest	chest	NN
cord-006860-a3b8hyyr	3866	13	pain	pain	NN
cord-006860-a3b8hyyr	3866	14	should	should	MD
cord-006860-a3b8hyyr	3866	15	result	result	VB
cord-006860-a3b8hyyr	3866	16	in	in	IN
cord-006860-a3b8hyyr	3866	17	careful	careful	JJ
cord-006860-a3b8hyyr	3866	18	examination	examination	NN
cord-006860-a3b8hyyr	3866	19	for	for	IN
cord-006860-a3b8hyyr	3866	20	signs	sign	NNS
cord-006860-a3b8hyyr	3866	21	of	of	IN
cord-006860-a3b8hyyr	3866	22	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	3866	23	embolism	embolism	NN
cord-006860-a3b8hyyr	3866	24	or	or	CC
cord-006860-a3b8hyyr	3866	25	aortic	aortic	JJ
cord-006860-a3b8hyyr	3866	26	aneurysm	aneurysm	NN
cord-006860-a3b8hyyr	3866	27	.	.	.
cord-006860-a3b8hyyr	3867	1	The	the	DT
cord-006860-a3b8hyyr	3867	2	possibility	possibility	NN
cord-006860-a3b8hyyr	3867	3	to	to	TO
cord-006860-a3b8hyyr	3867	4	determine	determine	VB
cord-006860-a3b8hyyr	3867	5	activated	activate	VBN
cord-006860-a3b8hyyr	3867	6	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3867	7	factors	factor	NNS
cord-006860-a3b8hyyr	3867	8	opens	open	VBZ
cord-006860-a3b8hyyr	3867	9	the	the	DT
cord-006860-a3b8hyyr	3867	10	question	question	NN
cord-006860-a3b8hyyr	3867	11	if	if	IN
cord-006860-a3b8hyyr	3867	12	data	datum	NNS
cord-006860-a3b8hyyr	3867	13	provide	provide	VBP
cord-006860-a3b8hyyr	3867	14	evidence	evidence	NN
cord-006860-a3b8hyyr	3867	15	of	of	IN
cord-006860-a3b8hyyr	3867	16	an	an	DT
cord-006860-a3b8hyyr	3867	17	activated	activate	VBN
cord-006860-a3b8hyyr	3867	18	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3867	19	or	or	CC
cord-006860-a3b8hyyr	3867	20	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	3867	21	and	and	CC
cord-006860-a3b8hyyr	3867	22	if	if	IN
cord-006860-a3b8hyyr	3867	23	this	this	DT
cord-006860-a3b8hyyr	3867	24	has	have	VBZ
cord-006860-a3b8hyyr	3867	25	a	a	DT
cord-006860-a3b8hyyr	3867	26	prospective	prospective	JJ
cord-006860-a3b8hyyr	3867	27	value	value	NN
cord-006860-a3b8hyyr	3867	28	.	.	.
cord-006860-a3b8hyyr	3868	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3868	2	investigated	investigate	VBD
cord-006860-a3b8hyyr	3868	3	patients	patient	NNS
cord-006860-a3b8hyyr	3868	4	with	with	IN
cord-006860-a3b8hyyr	3868	5	confirmed	confirmed	JJ
cord-006860-a3b8hyyr	3868	6	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3868	7	,	,	,
cord-006860-a3b8hyyr	3868	8	postsurgical	postsurgical	NNP
cord-006860-a3b8hyyr	3868	9	septieaemia	septieaemia	NNP
cord-006860-a3b8hyyr	3868	10	and	and	CC
cord-006860-a3b8hyyr	3868	11	also	also	RB
cord-006860-a3b8hyyr	3868	12	after	after	IN
cord-006860-a3b8hyyr	3868	13	liver	liver	NN
cord-006860-a3b8hyyr	3868	14	transplantation	transplantation	NN
cord-006860-a3b8hyyr	3868	15	.	.	.
cord-006860-a3b8hyyr	3869	1	In	in	IN
cord-006860-a3b8hyyr	3869	2	all	all	DT
cord-006860-a3b8hyyr	3869	3	patients	patient	NNS
cord-006860-a3b8hyyr	3869	4	factor	factor	NN
cord-006860-a3b8hyyr	3869	5	VIIa	VIIa	NNS
cord-006860-a3b8hyyr	3869	6	,	,	,
cord-006860-a3b8hyyr	3869	7	XII	XII	NNP
cord-006860-a3b8hyyr	3869	8	,	,	,
cord-006860-a3b8hyyr	3869	9	XIIa	XIIa	NNS
cord-006860-a3b8hyyr	3869	10	and	and	CC
cord-006860-a3b8hyyr	3869	11	also	also	RB
cord-006860-a3b8hyyr	3869	12	the	the	DT
cord-006860-a3b8hyyr	3869	13	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	3869	14	parameters	parameter	NNS
cord-006860-a3b8hyyr	3869	15	t	t	NNP
cord-006860-a3b8hyyr	3869	16	-	-	HYPH
cord-006860-a3b8hyyr	3869	17	PA	PA	NNP
cord-006860-a3b8hyyr	3869	18	,	,	,
cord-006860-a3b8hyyr	3869	19	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	3869	20	,	,	,
cord-006860-a3b8hyyr	3869	21	PAP	pap	NN
cord-006860-a3b8hyyr	3869	22	,	,	,
cord-006860-a3b8hyyr	3869	23	Plasminogen	Plasminogen	NNP
cord-006860-a3b8hyyr	3869	24	and	and	CC
cord-006860-a3b8hyyr	3869	25	a2-AP	a2-AP	NNP
cord-006860-a3b8hyyr	3869	26	were	be	VBD
cord-006860-a3b8hyyr	3869	27	determined	determine	VBN
cord-006860-a3b8hyyr	3869	28	.	.	.
cord-006860-a3b8hyyr	3870	1	In	in	IN
cord-006860-a3b8hyyr	3870	2	addition	addition	NN
cord-006860-a3b8hyyr	3870	3	,	,	,
cord-006860-a3b8hyyr	3870	4	F1	f1	NN
cord-006860-a3b8hyyr	3870	5	+	+	SYM
cord-006860-a3b8hyyr	3870	6	2	2	CD
cord-006860-a3b8hyyr	3870	7	and	and	CC
cord-006860-a3b8hyyr	3870	8	APC	APC	NNP
cord-006860-a3b8hyyr	3870	9	-	-	HYPH
cord-006860-a3b8hyyr	3870	10	resistance	resistance	NN
cord-006860-a3b8hyyr	3870	11	with	with	IN
cord-006860-a3b8hyyr	3870	12	heterocygote	heterocygote	NN
cord-006860-a3b8hyyr	3870	13	factor	factor	NNP
cord-006860-a3b8hyyr	3870	14	V	V	NNP
cord-006860-a3b8hyyr	3870	15	-	-	HYPH
cord-006860-a3b8hyyr	3870	16	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	3870	17	-	-	HYPH
cord-006860-a3b8hyyr	3870	18	mutation	mutation	NN
cord-006860-a3b8hyyr	3870	19	and	and	CC
cord-006860-a3b8hyyr	3870	20	confirmed	confirm	VBD
cord-006860-a3b8hyyr	3870	21	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3870	22	.	.	.
cord-006860-a3b8hyyr	3871	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3871	2	found	find	VBD
cord-006860-a3b8hyyr	3871	3	increased	increased	JJ
cord-006860-a3b8hyyr	3871	4	factor	factor	NN
cord-006860-a3b8hyyr	3871	5	VIIa	VIIa	NNS
cord-006860-a3b8hyyr	3871	6	which	which	WDT
cord-006860-a3b8hyyr	3871	7	showed	show	VBD
cord-006860-a3b8hyyr	3871	8	partly	partly	RB
cord-006860-a3b8hyyr	3871	9	also	also	RB
cord-006860-a3b8hyyr	3871	10	an	an	DT
cord-006860-a3b8hyyr	3871	11	increased	increase	VBN
cord-006860-a3b8hyyr	3871	12	Fl+2	Fl+2	NNS
cord-006860-a3b8hyyr	3871	13	.	.	.
cord-006860-a3b8hyyr	3872	1	Patients	patient	NNS
cord-006860-a3b8hyyr	3872	2	with	with	IN
cord-006860-a3b8hyyr	3872	3	other	other	JJ
cord-006860-a3b8hyyr	3872	4	pathological	pathological	JJ
cord-006860-a3b8hyyr	3872	5	results	result	NNS
cord-006860-a3b8hyyr	3872	6	such	such	JJ
cord-006860-a3b8hyyr	3872	7	as	as	IN
cord-006860-a3b8hyyr	3872	8	a	a	DT
cord-006860-a3b8hyyr	3872	9	reduced	reduced	JJ
cord-006860-a3b8hyyr	3872	10	t	t	NN
cord-006860-a3b8hyyr	3872	11	-	-	HYPH
cord-006860-a3b8hyyr	3872	12	PA	PA	NNP
cord-006860-a3b8hyyr	3872	13	and/or	and/or	CC
cord-006860-a3b8hyyr	3872	14	increased	increase	VBN
cord-006860-a3b8hyyr	3872	15	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	3872	16	showed	show	VBD
cord-006860-a3b8hyyr	3872	17	a	a	DT
cord-006860-a3b8hyyr	3872	18	low	low	JJ
cord-006860-a3b8hyyr	3872	19	incidence	incidence	NN
cord-006860-a3b8hyyr	3872	20	of	of	IN
cord-006860-a3b8hyyr	3872	21	elevations	elevation	NNS
cord-006860-a3b8hyyr	3872	22	in	in	IN
cord-006860-a3b8hyyr	3872	23	factor	factor	NN
cord-006860-a3b8hyyr	3872	24	VII	vii	NN
cord-006860-a3b8hyyr	3872	25	or	or	CC
cord-006860-a3b8hyyr	3872	26	F1	f1	NN
cord-006860-a3b8hyyr	3872	27	+	+	SYM
cord-006860-a3b8hyyr	3872	28	2	2	CD
cord-006860-a3b8hyyr	3872	29	.	.	.
cord-006860-a3b8hyyr	3873	1	The	the	DT
cord-006860-a3b8hyyr	3873	2	activation	activation	NN
cord-006860-a3b8hyyr	3873	3	of	of	IN
cord-006860-a3b8hyyr	3873	4	factor	factor	NN
cord-006860-a3b8hyyr	3873	5	XII	XII	NNP
cord-006860-a3b8hyyr	3873	6	seems	seem	VBZ
cord-006860-a3b8hyyr	3873	7	to	to	TO
cord-006860-a3b8hyyr	3873	8	be	be	VB
cord-006860-a3b8hyyr	3873	9	of	of	IN
cord-006860-a3b8hyyr	3873	10	minor	minor	JJ
cord-006860-a3b8hyyr	3873	11	importance	importance	NN
cord-006860-a3b8hyyr	3873	12	in	in	IN
cord-006860-a3b8hyyr	3873	13	patients	patient	NNS
cord-006860-a3b8hyyr	3873	14	with	with	IN
cord-006860-a3b8hyyr	3873	15	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3873	16	.	.	.
cord-006860-a3b8hyyr	3874	1	A	a	DT
cord-006860-a3b8hyyr	3874	2	different	different	JJ
cord-006860-a3b8hyyr	3874	3	picture	picture	NN
cord-006860-a3b8hyyr	3874	4	is	be	VBZ
cord-006860-a3b8hyyr	3874	5	found	find	VBN
cord-006860-a3b8hyyr	3874	6	in	in	IN
cord-006860-a3b8hyyr	3874	7	septic	septic	JJ
cord-006860-a3b8hyyr	3874	8	and	and	CC
cord-006860-a3b8hyyr	3874	9	transplanted	transplanted	JJ
cord-006860-a3b8hyyr	3874	10	patients	patient	NNS
cord-006860-a3b8hyyr	3874	11	.	.	.
cord-006860-a3b8hyyr	3875	1	Obviously	obviously	RB
cord-006860-a3b8hyyr	3875	2	factor	factor	NN
cord-006860-a3b8hyyr	3875	3	XII	xii	NN
cord-006860-a3b8hyyr	3875	4	-	-	HYPH
cord-006860-a3b8hyyr	3875	5	activation	activation	NN
cord-006860-a3b8hyyr	3875	6	is	be	VBZ
cord-006860-a3b8hyyr	3875	7	of	of	IN
cord-006860-a3b8hyyr	3875	8	major	major	JJ
cord-006860-a3b8hyyr	3875	9	importance	importance	NN
cord-006860-a3b8hyyr	3875	10	in	in	IN
cord-006860-a3b8hyyr	3875	11	this	this	DT
cord-006860-a3b8hyyr	3875	12	group	group	NN
cord-006860-a3b8hyyr	3875	13	.	.	.
cord-006860-a3b8hyyr	3876	1	A	a	DT
cord-006860-a3b8hyyr	3876	2	deterioration	deterioration	NN
cord-006860-a3b8hyyr	3876	3	of	of	IN
cord-006860-a3b8hyyr	3876	4	the	the	DT
cord-006860-a3b8hyyr	3876	5	clinical	clinical	JJ
cord-006860-a3b8hyyr	3876	6	symptoms	symptom	NNS
cord-006860-a3b8hyyr	3876	7	is	be	VBZ
cord-006860-a3b8hyyr	3876	8	correlated	correlate	VBN
cord-006860-a3b8hyyr	3876	9	with	with	IN
cord-006860-a3b8hyyr	3876	10	an	an	DT
cord-006860-a3b8hyyr	3876	11	increased	increase	VBN
cord-006860-a3b8hyyr	3876	12	factor	factor	NN
cord-006860-a3b8hyyr	3876	13	XIIa	XIIa	NNS
cord-006860-a3b8hyyr	3876	14	which	which	WDT
cord-006860-a3b8hyyr	3876	15	is	be	VBZ
cord-006860-a3b8hyyr	3876	16	paralleled	parallel	VBN
cord-006860-a3b8hyyr	3876	17	by	by	IN
cord-006860-a3b8hyyr	3876	18	a	a	DT
cord-006860-a3b8hyyr	3876	19	decrease	decrease	NN
cord-006860-a3b8hyyr	3876	20	of	of	IN
cord-006860-a3b8hyyr	3876	21	factor	factor	NN
cord-006860-a3b8hyyr	3876	22	XIIactivity	xiiactivity	NN
cord-006860-a3b8hyyr	3876	23	.	.	.
cord-006860-a3b8hyyr	3877	1	The	the	DT
cord-006860-a3b8hyyr	3877	2	investigation	investigation	NN
cord-006860-a3b8hyyr	3877	3	of	of	IN
cord-006860-a3b8hyyr	3877	4	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	3877	5	parameters	parameter	NNS
cord-006860-a3b8hyyr	3877	6	such	such	JJ
cord-006860-a3b8hyyr	3877	7	as	as	IN
cord-006860-a3b8hyyr	3877	8	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	3877	9	and	and	CC
cord-006860-a3b8hyyr	3877	10	PAP	pap	NN
cord-006860-a3b8hyyr	3877	11	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	3877	12	a	a	DT
cord-006860-a3b8hyyr	3877	13	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	3877	14	disturbance	disturbance	NN
cord-006860-a3b8hyyr	3877	15	of	of	IN
cord-006860-a3b8hyyr	3877	16	the	the	DT
cord-006860-a3b8hyyr	3877	17	balance	balance	NN
cord-006860-a3b8hyyr	3877	18	.	.	.
cord-006860-a3b8hyyr	3878	1	Statistically	statistically	RB
cord-006860-a3b8hyyr	3878	2	significant	significant	JJ
cord-006860-a3b8hyyr	3878	3	are	be	VBP
cord-006860-a3b8hyyr	3878	4	differences	difference	NNS
cord-006860-a3b8hyyr	3878	5	in	in	IN
cord-006860-a3b8hyyr	3878	6	septicaemic	septicaemic	JJ
cord-006860-a3b8hyyr	3878	7	patients	patient	NNS
cord-006860-a3b8hyyr	3878	8	both	both	CC
cord-006860-a3b8hyyr	3878	9	in	in	IN
cord-006860-a3b8hyyr	3878	10	the	the	DT
cord-006860-a3b8hyyr	3878	11	surgical	surgical	JJ
cord-006860-a3b8hyyr	3878	12	and	and	CC
cord-006860-a3b8hyyr	3878	13	in	in	IN
cord-006860-a3b8hyyr	3878	14	the	the	DT
cord-006860-a3b8hyyr	3878	15	internistical	internistical	JJ
cord-006860-a3b8hyyr	3878	16	group	group	NN
cord-006860-a3b8hyyr	3878	17	in	in	IN
cord-006860-a3b8hyyr	3878	18	contrast	contrast	NN
cord-006860-a3b8hyyr	3878	19	to	to	IN
cord-006860-a3b8hyyr	3878	20	polytrauma	polytrauma	NN
cord-006860-a3b8hyyr	3878	21	patients	patient	NNS
cord-006860-a3b8hyyr	3878	22	.	.	.
cord-006860-a3b8hyyr	3879	1	In	in	IN
cord-006860-a3b8hyyr	3879	2	patients	patient	NNS
cord-006860-a3b8hyyr	3879	3	with	with	IN
cord-006860-a3b8hyyr	3879	4	liver	liver	NN
cord-006860-a3b8hyyr	3879	5	transplantations	transplantation	NNS
cord-006860-a3b8hyyr	3879	6	significant	significant	JJ
cord-006860-a3b8hyyr	3879	7	changes	change	NNS
cord-006860-a3b8hyyr	3879	8	are	be	VBP
cord-006860-a3b8hyyr	3879	9	apparently	apparently	RB
cord-006860-a3b8hyyr	3879	10	related	relate	VBN
cord-006860-a3b8hyyr	3879	11	to	to	IN
cord-006860-a3b8hyyr	3879	12	rejection	rejection	NN
cord-006860-a3b8hyyr	3879	13	of	of	IN
cord-006860-a3b8hyyr	3879	14	the	the	DT
cord-006860-a3b8hyyr	3879	15	transplanted	transplanted	JJ
cord-006860-a3b8hyyr	3879	16	organ	organ	NN
cord-006860-a3b8hyyr	3879	17	together	together	RB
cord-006860-a3b8hyyr	3879	18	with	with	IN
cord-006860-a3b8hyyr	3879	19	a	a	DT
cord-006860-a3b8hyyr	3879	20	deterioration	deterioration	NN
cord-006860-a3b8hyyr	3879	21	of	of	IN
cord-006860-a3b8hyyr	3879	22	the	the	DT
cord-006860-a3b8hyyr	3879	23	clinical	clinical	JJ
cord-006860-a3b8hyyr	3879	24	picture	picture	NN
cord-006860-a3b8hyyr	3879	25	.	.	.
cord-006860-a3b8hyyr	3880	1	The	the	DT
cord-006860-a3b8hyyr	3880	2	possibility	possibility	NN
cord-006860-a3b8hyyr	3880	3	to	to	TO
cord-006860-a3b8hyyr	3880	4	detect	detect	VB
cord-006860-a3b8hyyr	3880	5	activated	activate	VBN
cord-006860-a3b8hyyr	3880	6	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3880	7	factors	factor	NNS
cord-006860-a3b8hyyr	3880	8	may	may	MD
cord-006860-a3b8hyyr	3880	9	be	be	VB
cord-006860-a3b8hyyr	3880	10	a	a	DT
cord-006860-a3b8hyyr	3880	11	tool	tool	NN
cord-006860-a3b8hyyr	3880	12	to	to	TO
cord-006860-a3b8hyyr	3880	13	detect	detect	VB
cord-006860-a3b8hyyr	3880	14	changes	change	NNS
cord-006860-a3b8hyyr	3880	15	in	in	IN
cord-006860-a3b8hyyr	3880	16	the	the	DT
cord-006860-a3b8hyyr	3880	17	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	3880	18	system	system	NN
cord-006860-a3b8hyyr	3880	19	at	at	IN
cord-006860-a3b8hyyr	3880	20	an	an	DT
cord-006860-a3b8hyyr	3880	21	early	early	JJ
cord-006860-a3b8hyyr	3880	22	stage	stage	NN
cord-006860-a3b8hyyr	3880	23	and	and	CC
cord-006860-a3b8hyyr	3880	24	to	to	TO
cord-006860-a3b8hyyr	3880	25	use	use	VB
cord-006860-a3b8hyyr	3880	26	this	this	DT
cord-006860-a3b8hyyr	3880	27	for	for	IN
cord-006860-a3b8hyyr	3880	28	an	an	DT
cord-006860-a3b8hyyr	3880	29	improved	improved	JJ
cord-006860-a3b8hyyr	3880	30	therapy	therapy	NN
cord-006860-a3b8hyyr	3880	31	.	.	.
cord-006860-a3b8hyyr	3881	1	Control	control	NN
cord-006860-a3b8hyyr	3881	2	of	of	IN
cord-006860-a3b8hyyr	3881	3	long	long	JJ
cord-006860-a3b8hyyr	3881	4	-	-	HYPH
cord-006860-a3b8hyyr	3881	5	term	term	NN
cord-006860-a3b8hyyr	3881	6	oral	oral	JJ
cord-006860-a3b8hyyr	3881	7	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3881	8	is	be	VBZ
cord-006860-a3b8hyyr	3881	9	usually	usually	RB
cord-006860-a3b8hyyr	3881	10	performed	perform	VBN
cord-006860-a3b8hyyr	3881	11	by	by	IN
cord-006860-a3b8hyyr	3881	12	serial	serial	JJ
cord-006860-a3b8hyyr	3881	13	determinations	determination	NNS
cord-006860-a3b8hyyr	3881	14	of	of	IN
cord-006860-a3b8hyyr	3881	15	the	the	DT
cord-006860-a3b8hyyr	3881	16	prothrombin	prothrombin	JJ
cord-006860-a3b8hyyr	3881	17	time	time	NN
cord-006860-a3b8hyyr	3881	18	.	.	.
cord-006860-a3b8hyyr	3882	1	However	however	RB
cord-006860-a3b8hyyr	3882	2	,	,	,
cord-006860-a3b8hyyr	3882	3	the	the	DT
cord-006860-a3b8hyyr	3882	4	assessment	assessment	NN
cord-006860-a3b8hyyr	3882	5	of	of	IN
cord-006860-a3b8hyyr	3882	6	effective	effective	JJ
cord-006860-a3b8hyyr	3882	7	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3882	8	versus	versus	IN
cord-006860-a3b8hyyr	3882	9	the	the	DT
cord-006860-a3b8hyyr	3882	10	potential	potential	JJ
cord-006860-a3b8hyyr	3882	11	risk	risk	NN
cord-006860-a3b8hyyr	3882	12	of	of	IN
cord-006860-a3b8hyyr	3882	13	bleeding	bleed	VBG
cord-006860-a3b8hyyr	3882	14	complication	complication	NN
cord-006860-a3b8hyyr	3882	15	is	be	VBZ
cord-006860-a3b8hyyr	3882	16	difficult	difficult	JJ
cord-006860-a3b8hyyr	3882	17	to	to	TO
cord-006860-a3b8hyyr	3882	18	achieve	achieve	VB
cord-006860-a3b8hyyr	3882	19	.	.	.
cord-006860-a3b8hyyr	3883	1	Molecular	molecular	JJ
cord-006860-a3b8hyyr	3883	2	markers	marker	NNS
cord-006860-a3b8hyyr	3883	3	of	of	IN
cord-006860-a3b8hyyr	3883	4	blood	blood	NN
cord-006860-a3b8hyyr	3883	5	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3883	6	activation	activation	NN
cord-006860-a3b8hyyr	3883	7	might	may	MD
cord-006860-a3b8hyyr	3883	8	add	add	VB
cord-006860-a3b8hyyr	3883	9	valuable	valuable	JJ
cord-006860-a3b8hyyr	3883	10	information	information	NN
cord-006860-a3b8hyyr	3883	11	in	in	IN
cord-006860-a3b8hyyr	3883	12	individual	individual	JJ
cord-006860-a3b8hyyr	3883	13	cases	case	NNS
cord-006860-a3b8hyyr	3883	14	.	.	.
cord-006860-a3b8hyyr	3884	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3884	2	investigated	investigate	VBD
cord-006860-a3b8hyyr	3884	3	48	48	CD
cord-006860-a3b8hyyr	3884	4	patients	patient	NNS
cord-006860-a3b8hyyr	3884	5	with	with	IN
cord-006860-a3b8hyyr	3884	6	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	3884	7	manifestations	manifestation	NNS
cord-006860-a3b8hyyr	3884	8	(	(	-LRB-
cord-006860-a3b8hyyr	3884	9	deep	deep	JJ
cord-006860-a3b8hyyr	3884	10	vein	vein	NN
cord-006860-a3b8hyyr	3884	11	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3884	12	n=22	n=22	NNP
cord-006860-a3b8hyyr	3884	13	,	,	,
cord-006860-a3b8hyyr	3884	14	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	3884	15	embolism	embolism	NN
cord-006860-a3b8hyyr	3884	16	n=	n=	NNP
cord-006860-a3b8hyyr	3884	17	13	13	CD
cord-006860-a3b8hyyr	3884	18	,	,	,
cord-006860-a3b8hyyr	3884	19	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	3884	20	infarction	infarction	NN
cord-006860-a3b8hyyr	3884	21	n=	n=	NNP
cord-006860-a3b8hyyr	3884	22	13	13	CD
cord-006860-a3b8hyyr	3884	23	)	)	-RRB-
cord-006860-a3b8hyyr	3884	24	for	for	IN
cord-006860-a3b8hyyr	3884	25	one	one	CD
cord-006860-a3b8hyyr	3884	26	year	year	NN
cord-006860-a3b8hyyr	3884	27	beginning	begin	VBG
cord-006860-a3b8hyyr	3884	28	with	with	IN
cord-006860-a3b8hyyr	3884	29	admission	admission	NN
cord-006860-a3b8hyyr	3884	30	to	to	IN
cord-006860-a3b8hyyr	3884	31	the	the	DT
cord-006860-a3b8hyyr	3884	32	hospital	hospital	NN
cord-006860-a3b8hyyr	3884	33	.	.	.
cord-006860-a3b8hyyr	3885	1	TAT	tat	NN
cord-006860-a3b8hyyr	3885	2	,	,	,
cord-006860-a3b8hyyr	3885	3	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3885	4	fragments	fragment	NNS
cord-006860-a3b8hyyr	3885	5	F	F	NNP
cord-006860-a3b8hyyr	3885	6	1	1	CD
cord-006860-a3b8hyyr	3885	7	+2	+2	NNP
cord-006860-a3b8hyyr	3885	8	,	,	,
cord-006860-a3b8hyyr	3885	9	D	d	NN
cord-006860-a3b8hyyr	3885	10	-	-	HYPH
cord-006860-a3b8hyyr	3885	11	dirner	dirner	NN
cord-006860-a3b8hyyr	3885	12	and	and	CC
cord-006860-a3b8hyyr	3885	13	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3885	14	monomer	monomer	NN
cord-006860-a3b8hyyr	3885	15	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3885	16	were	be	VBD
cord-006860-a3b8hyyr	3885	17	analysed	analyse	VBN
cord-006860-a3b8hyyr	3885	18	.	.	.
cord-006860-a3b8hyyr	3886	1	All	all	DT
cord-006860-a3b8hyyr	3886	2	markers	marker	NNS
cord-006860-a3b8hyyr	3886	3	were	be	VBD
cord-006860-a3b8hyyr	3886	4	significantly	significantly	RB
cord-006860-a3b8hyyr	3886	5	increased	increase	VBN
cord-006860-a3b8hyyr	3886	6	at	at	IN
cord-006860-a3b8hyyr	3886	7	the	the	DT
cord-006860-a3b8hyyr	3886	8	time	time	NN
cord-006860-a3b8hyyr	3886	9	of	of	IN
cord-006860-a3b8hyyr	3886	10	initiation	initiation	NN
cord-006860-a3b8hyyr	3886	11	of	of	IN
cord-006860-a3b8hyyr	3886	12	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	3886	13	therapy	therapy	NN
cord-006860-a3b8hyyr	3886	14	thus	thus	RB
cord-006860-a3b8hyyr	3886	15	reflecting	reflect	VBG
cord-006860-a3b8hyyr	3886	16	a	a	DT
cord-006860-a3b8hyyr	3886	17	prethrombotic	prethrombotic	JJ
cord-006860-a3b8hyyr	3886	18	situation	situation	NN
cord-006860-a3b8hyyr	3886	19	.	.	.
cord-006860-a3b8hyyr	3887	1	Patients	patient	NNS
cord-006860-a3b8hyyr	3887	2	suffering	suffer	VBG
cord-006860-a3b8hyyr	3887	3	from	from	IN
cord-006860-a3b8hyyr	3887	4	venous	venous	JJ
cord-006860-a3b8hyyr	3887	5	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	3887	6	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	3887	7	higher	high	JJR
cord-006860-a3b8hyyr	3887	8	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3887	9	of	of	IN
cord-006860-a3b8hyyr	3887	10	TAT	TAT	NNP
cord-006860-a3b8hyyr	3887	11	and	and	CC
cord-006860-a3b8hyyr	3887	12	F	F	NNP
cord-006860-a3b8hyyr	3887	13	1	1	CD
cord-006860-a3b8hyyr	3887	14	+2	+2	CD
cord-006860-a3b8hyyr	3887	15	in	in	IN
cord-006860-a3b8hyyr	3887	16	comparison	comparison	NN
cord-006860-a3b8hyyr	3887	17	to	to	IN
cord-006860-a3b8hyyr	3887	18	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	3887	19	infarction	infarction	NN
cord-006860-a3b8hyyr	3887	20	(	(	-LRB-
cord-006860-a3b8hyyr	3887	21	34.6	34.6	CD
cord-006860-a3b8hyyr	3887	22	vs	vs	IN
cord-006860-a3b8hyyr	3887	23	12.3	12.3	CD
cord-006860-a3b8hyyr	3887	24	pg/1	pg/1	NN
cord-006860-a3b8hyyr	3887	25	,	,	,
cord-006860-a3b8hyyr	3887	26	p	p	NN
cord-006860-a3b8hyyr	3887	27	=	=	SYM
cord-006860-a3b8hyyr	3887	28	O.009	o.009	NN
cord-006860-a3b8hyyr	3887	29	;	;	:
cord-006860-a3b8hyyr	3887	30	2.8	2.8	CD
cord-006860-a3b8hyyr	3887	31	vs	vs	IN
cord-006860-a3b8hyyr	3887	32	1.3	1.3	CD
cord-006860-a3b8hyyr	3887	33	nmol	nmol	JJ
cord-006860-a3b8hyyr	3887	34	/	/	,
cord-006860-a3b8hyyr	3887	35	I	-PRON-	PRP
cord-006860-a3b8hyyr	3887	36	,	,	,
cord-006860-a3b8hyyr	3887	37	p=0.0025	p=0.0025	NNP
cord-006860-a3b8hyyr	3887	38	)	)	-RRB-
cord-006860-a3b8hyyr	3887	39	.	.	.
cord-006860-a3b8hyyr	3888	1	F	F	NNP
cord-006860-a3b8hyyr	3888	2	1	1	CD
cord-006860-a3b8hyyr	3888	3	+2	+2	NNP
cord-006860-a3b8hyyr	3888	4	,	,	,
cord-006860-a3b8hyyr	3888	5	TAT	tat	NN
cord-006860-a3b8hyyr	3888	6	and	and	CC
cord-006860-a3b8hyyr	3888	7	D	d	NN
cord-006860-a3b8hyyr	3888	8	-	-	HYPH
cord-006860-a3b8hyyr	3888	9	dimer	dimer	NN
cord-006860-a3b8hyyr	3888	10	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3888	11	decreased	decrease	VBD
cord-006860-a3b8hyyr	3888	12	gradually	gradually	RB
cord-006860-a3b8hyyr	3888	13	over	over	IN
cord-006860-a3b8hyyr	3888	14	the	the	DT
cord-006860-a3b8hyyr	3888	15	first	first	JJ
cord-006860-a3b8hyyr	3888	16	14	14	CD
cord-006860-a3b8hyyr	3888	17	days	day	NNS
cord-006860-a3b8hyyr	3888	18	of	of	IN
cord-006860-a3b8hyyr	3888	19	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3888	20	therapy	therapy	NN
cord-006860-a3b8hyyr	3888	21	reaching	reach	VBG
cord-006860-a3b8hyyr	3888	22	values	value	NNS
cord-006860-a3b8hyyr	3888	23	within	within	IN
cord-006860-a3b8hyyr	3888	24	the	the	DT
cord-006860-a3b8hyyr	3888	25	established	establish	VBN
cord-006860-a3b8hyyr	3888	26	normal	normal	JJ
cord-006860-a3b8hyyr	3888	27	ranges	range	NNS
cord-006860-a3b8hyyr	3888	28	in	in	IN
cord-006860-a3b8hyyr	3888	29	all	all	DT
cord-006860-a3b8hyyr	3888	30	cases	case	NNS
cord-006860-a3b8hyyr	3888	31	.	.	.
cord-006860-a3b8hyyr	3889	1	F	F	NNP
cord-006860-a3b8hyyr	3889	2	1	1	CD
cord-006860-a3b8hyyr	3889	3	+2	+2	SYM
cord-006860-a3b8hyyr	3889	4	and	and	CC
cord-006860-a3b8hyyr	3889	5	TAT	tat	NN
cord-006860-a3b8hyyr	3889	6	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3889	7	reflect	reflect	VBP
cord-006860-a3b8hyyr	3889	8	the	the	DT
cord-006860-a3b8hyyr	3889	9	activity	activity	NN
cord-006860-a3b8hyyr	3889	10	of	of	IN
cord-006860-a3b8hyyr	3889	11	the	the	DT
cord-006860-a3b8hyyr	3889	12	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3889	13	system	system	NN
cord-006860-a3b8hyyr	3889	14	during	during	IN
cord-006860-a3b8hyyr	3889	15	long	long	JJ
cord-006860-a3b8hyyr	3889	16	-	-	HYPH
cord-006860-a3b8hyyr	3889	17	term	term	NN
cord-006860-a3b8hyyr	3889	18	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	3889	19	whereas	whereas	IN
cord-006860-a3b8hyyr	3889	20	analysis	analysis	NN
cord-006860-a3b8hyyr	3889	21	of	of	IN
cord-006860-a3b8hyyr	3889	22	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3889	23	monomer	monomer	NN
cord-006860-a3b8hyyr	3889	24	yielded	yield	VBD
cord-006860-a3b8hyyr	3889	25	partly	partly	RB
cord-006860-a3b8hyyr	3889	26	controversial	controversial	JJ
cord-006860-a3b8hyyr	3889	27	results	result	NNS
cord-006860-a3b8hyyr	3889	28	.	.	.
cord-006860-a3b8hyyr	3890	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3890	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	3890	3	that	that	IN
cord-006860-a3b8hyyr	3890	4	F	F	NNP
cord-006860-a3b8hyyr	3890	5	1	1	CD
cord-006860-a3b8hyyr	3890	6	+	+	SYM
cord-006860-a3b8hyyr	3890	7	2	2	CD
cord-006860-a3b8hyyr	3890	8	and	and	CC
cord-006860-a3b8hyyr	3890	9	TAT	tat	NN
cord-006860-a3b8hyyr	3890	10	appear	appear	VBP
cord-006860-a3b8hyyr	3890	11	to	to	TO
cord-006860-a3b8hyyr	3890	12	be	be	VB
cord-006860-a3b8hyyr	3890	13	superior	superior	JJ
cord-006860-a3b8hyyr	3890	14	to	to	TO
cord-006860-a3b8hyyr	3890	15	fibrin	fibrin	NN
cord-006860-a3b8hyyr	3890	16	monomer	monomer	NN
cord-006860-a3b8hyyr	3890	17	for	for	IN
cord-006860-a3b8hyyr	3890	18	the	the	DT
cord-006860-a3b8hyyr	3890	19	individual	individual	JJ
cord-006860-a3b8hyyr	3890	20	control	control	NN
cord-006860-a3b8hyyr	3890	21	of	of	IN
cord-006860-a3b8hyyr	3890	22	oral	oral	JJ
cord-006860-a3b8hyyr	3890	23	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	3890	24	therapy	therapy	NN
cord-006860-a3b8hyyr	3890	25	.	.	.
cord-006860-a3b8hyyr	3891	1	The	the	DT
cord-006860-a3b8hyyr	3891	2	influence	influence	NN
cord-006860-a3b8hyyr	3891	3	of	of	IN
cord-006860-a3b8hyyr	3891	4	thyroid	thyroid	NN
cord-006860-a3b8hyyr	3891	5	failure	failure	NN
cord-006860-a3b8hyyr	3891	6	on	on	IN
cord-006860-a3b8hyyr	3891	7	haemostasis	haemostasis	NN
cord-006860-a3b8hyyr	3891	8	is	be	VBZ
cord-006860-a3b8hyyr	3891	9	controversial	controversial	JJ
cord-006860-a3b8hyyr	3891	10	.	.	.
cord-006860-a3b8hyyr	3892	1	Mainly	mainly	RB
cord-006860-a3b8hyyr	3892	2	hypoceagulable	hypoceagulable	JJ
cord-006860-a3b8hyyr	3892	3	states	state	NNS
cord-006860-a3b8hyyr	3892	4	have	have	VBP
cord-006860-a3b8hyyr	3892	5	been	be	VBN
cord-006860-a3b8hyyr	3892	6	described	describe	VBN
cord-006860-a3b8hyyr	3892	7	in	in	IN
cord-006860-a3b8hyyr	3892	8	clinically	clinically	RB
cord-006860-a3b8hyyr	3892	9	overt	overt	JJ
cord-006860-a3b8hyyr	3892	10	hypothyroidism	hypothyroidism	NN
cord-006860-a3b8hyyr	3892	11	.	.	.
cord-006860-a3b8hyyr	3893	1	Since	since	IN
cord-006860-a3b8hyyr	3893	2	hypothyroidism	hypothyroidism	NN
cord-006860-a3b8hyyr	3893	3	has	have	VBZ
cord-006860-a3b8hyyr	3893	4	been	be	VBN
cord-006860-a3b8hyyr	3893	5	associated	associate	VBN
cord-006860-a3b8hyyr	3893	6	with	with	IN
cord-006860-a3b8hyyr	3893	7	an	an	DT
cord-006860-a3b8hyyr	3893	8	increased	increase	VBN
cord-006860-a3b8hyyr	3893	9	risk	risk	NN
cord-006860-a3b8hyyr	3893	10	of	of	IN
cord-006860-a3b8hyyr	3893	11	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	3893	12	,	,	,
cord-006860-a3b8hyyr	3893	13	we	-PRON-	PRP
cord-006860-a3b8hyyr	3893	14	studied	study	VBD
cord-006860-a3b8hyyr	3893	15	a	a	DT
cord-006860-a3b8hyyr	3893	16	wide	wide	JJ
cord-006860-a3b8hyyr	3893	17	range	range	NN
cord-006860-a3b8hyyr	3893	18	of	of	IN
cord-006860-a3b8hyyr	3893	19	haemostatic	haemostatic	JJ
cord-006860-a3b8hyyr	3893	20	factors	factor	NNS
cord-006860-a3b8hyyr	3893	21	in	in	IN
cord-006860-a3b8hyyr	3893	22	untreated	untreated	JJ
cord-006860-a3b8hyyr	3893	23	female	female	JJ
cord-006860-a3b8hyyr	3893	24	patients	patient	NNS
cord-006860-a3b8hyyr	3893	25	with	with	IN
cord-006860-a3b8hyyr	3893	26	subclinical	subclinical	JJ
cord-006860-a3b8hyyr	3893	27	(	(	-LRB-
cord-006860-a3b8hyyr	3893	28	B	b	NN
cord-006860-a3b8hyyr	3893	29	,	,	,
cord-006860-a3b8hyyr	3893	30	n=42	n=42	NN
cord-006860-a3b8hyyr	3893	31	,	,	,
cord-006860-a3b8hyyr	3893	32	age	age	NN
cord-006860-a3b8hyyr	3893	33	59	59	CD
cord-006860-a3b8hyyr	3893	34	+	+	SYM
cord-006860-a3b8hyyr	3893	35	13	13	CD
cord-006860-a3b8hyyr	3893	36	)	)	-RRB-
cord-006860-a3b8hyyr	3893	37	or	or	CC
cord-006860-a3b8hyyr	3893	38	overt	overt	JJ
cord-006860-a3b8hyyr	3893	39	(	(	-LRB-
cord-006860-a3b8hyyr	3893	40	C	c	NN
cord-006860-a3b8hyyr	3893	41	,	,	,
cord-006860-a3b8hyyr	3893	42	n=8	n=8	NN
cord-006860-a3b8hyyr	3893	43	,	,	,
cord-006860-a3b8hyyr	3893	44	age	age	NN
cord-006860-a3b8hyyr	3893	45	55-zcJ	55-zcj	CD
cord-006860-a3b8hyyr	3893	46	)	)	-RRB-
cord-006860-a3b8hyyr	3893	47	hypothyroidism	hypothyroidism	NN
cord-006860-a3b8hyyr	3893	48	,	,	,
cord-006860-a3b8hyyr	3893	49	as	as	RB
cord-006860-a3b8hyyr	3893	50	well	well	RB
cord-006860-a3b8hyyr	3893	51	as	as	IN
cord-006860-a3b8hyyr	3893	52	in	in	IN
cord-006860-a3b8hyyr	3893	53	hypothyroid	hypothyroid	JJ
cord-006860-a3b8hyyr	3893	54	women	woman	NNS
cord-006860-a3b8hyyr	3893	55	under	under	IN
cord-006860-a3b8hyyr	3893	56	1"4	1"4	CD
cord-006860-a3b8hyyr	3893	57	treatment	treatment	NN
cord-006860-a3b8hyyr	3893	58	(	(	-LRB-
cord-006860-a3b8hyyr	3893	59	D	D	NNP
cord-006860-a3b8hyyr	3893	60	,	,	,
cord-006860-a3b8hyyr	3893	61	n=8	n=8	NN
cord-006860-a3b8hyyr	3893	62	,	,	,
cord-006860-a3b8hyyr	3893	63	age	age	NN
cord-006860-a3b8hyyr	3893	64	57	57	CD
cord-006860-a3b8hyyr	3893	65	+	+	SYM
cord-006860-a3b8hyyr	3893	66	9	9	CD
cord-006860-a3b8hyyr	3893	67	)	)	-RRB-
cord-006860-a3b8hyyr	3893	68	and	and	CC
cord-006860-a3b8hyyr	3893	69	euthyroid	euthyroid	NNP
cord-006860-a3b8hyyr	3893	70	controls	control	VBZ
cord-006860-a3b8hyyr	3893	71	(	(	-LRB-
cord-006860-a3b8hyyr	3893	72	A	A	NNP
cord-006860-a3b8hyyr	3893	73	,	,	,
cord-006860-a3b8hyyr	3893	74	n=80	n=80	NN
cord-006860-a3b8hyyr	3893	75	,	,	,
cord-006860-a3b8hyyr	3893	76	age	age	NN
cord-006860-a3b8hyyr	3893	77	50	50	CD
cord-006860-a3b8hyyr	3893	78	+	+	SYM
cord-006860-a3b8hyyr	3893	79	14	14	CD
cord-006860-a3b8hyyr	3893	80	)	)	-RRB-
cord-006860-a3b8hyyr	3893	81	.	.	.
cord-006860-a3b8hyyr	3894	1	Simple	simple	JJ
cord-006860-a3b8hyyr	3894	2	screening	screening	NN
cord-006860-a3b8hyyr	3894	3	tests	test	NNS
cord-006860-a3b8hyyr	3894	4	(	(	-LRB-
cord-006860-a3b8hyyr	3894	5	prothrombin	prothrombin	JJ
cord-006860-a3b8hyyr	3894	6	time	time	NN
cord-006860-a3b8hyyr	3894	7	,	,	,
cord-006860-a3b8hyyr	3894	8	activated	activate	VBD
cord-006860-a3b8hyyr	3894	9	partial	partial	JJ
cord-006860-a3b8hyyr	3894	10	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	3894	11	time	time	NN
cord-006860-a3b8hyyr	3894	12	,	,	,
cord-006860-a3b8hyyr	3894	13	fibdnogen	fibdnogen	NNP
cord-006860-a3b8hyyr	3894	14	)	)	-RRB-
cord-006860-a3b8hyyr	3894	15	,	,	,
cord-006860-a3b8hyyr	3894	16	procoagulant	procoagulant	NN
cord-006860-a3b8hyyr	3894	17	factors	factor	NNS
cord-006860-a3b8hyyr	3894	18	(	(	-LRB-
cord-006860-a3b8hyyr	3894	19	FVII	FVII	NNP
cord-006860-a3b8hyyr	3894	20	,	,	,
cord-006860-a3b8hyyr	3894	21	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	3894	22	,	,	,
cord-006860-a3b8hyyr	3894	23	von	von	NNP
cord-006860-a3b8hyyr	3894	24	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	3894	25	factor	factor	NN
cord-006860-a3b8hyyr	3894	26	)	)	-RRB-
cord-006860-a3b8hyyr	3894	27	,	,	,
cord-006860-a3b8hyyr	3894	28	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3894	29	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	3894	30	(	(	-LRB-
cord-006860-a3b8hyyr	3894	31	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3894	32	Ill	Ill	NNP
cord-006860-a3b8hyyr	3894	33	,	,	,
cord-006860-a3b8hyyr	3894	34	hepadn	hepadn	NNP
cord-006860-a3b8hyyr	3894	35	cofactor	cofactor	NN
cord-006860-a3b8hyyr	3894	36	II	II	NNP
cord-006860-a3b8hyyr	3894	37	,	,	,
cord-006860-a3b8hyyr	3894	38	protein	protein	NN
cord-006860-a3b8hyyr	3894	39	C	c	NN
cord-006860-a3b8hyyr	3894	40	,	,	,
cord-006860-a3b8hyyr	3894	41	protein	protein	NN
cord-006860-a3b8hyyr	3894	42	S	S	NNP
cord-006860-a3b8hyyr	3894	43	)	)	-RRB-
cord-006860-a3b8hyyr	3894	44	and	and	CC
cord-006860-a3b8hyyr	3894	45	fibdnolytic	fibdnolytic	JJ
cord-006860-a3b8hyyr	3894	46	factors	factor	NNS
cord-006860-a3b8hyyr	3894	47	(	(	-LRB-
cord-006860-a3b8hyyr	3894	48	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	3894	49	,	,	,
cord-006860-a3b8hyyr	3894	50	antiplasmin	antiplasmin	NNP
cord-006860-a3b8hyyr	3894	51	,	,	,
cord-006860-a3b8hyyr	3894	52	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	3894	53	activator	activator	NN
cord-006860-a3b8hyyr	3894	54	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	3894	55	,	,	,
cord-006860-a3b8hyyr	3894	56	tissue	tissue	NN
cord-006860-a3b8hyyr	3894	57	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	3894	58	activator	activator	NN
cord-006860-a3b8hyyr	3894	59	)	)	-RRB-
cord-006860-a3b8hyyr	3894	60	were	be	VBD
cord-006860-a3b8hyyr	3894	61	measured	measure	VBN
cord-006860-a3b8hyyr	3894	62	.	.	.
cord-006860-a3b8hyyr	3895	1	Results	result	NNS
cord-006860-a3b8hyyr	3895	2	Factor	Factor	NNP
cord-006860-a3b8hyyr	3895	3	VII	VII	NNP
cord-006860-a3b8hyyr	3895	4	activity	activity	NN
cord-006860-a3b8hyyr	3895	5	(	(	-LRB-
cord-006860-a3b8hyyr	3895	6	VII	vii	NN
cord-006860-a3b8hyyr	3895	7	:	:	:
cord-006860-a3b8hyyr	3895	8	C	C	NNP
cord-006860-a3b8hyyr	3895	9	)	)	-RRB-
cord-006860-a3b8hyyr	3895	10	,	,	,
cord-006860-a3b8hyyr	3895	11	factor	factor	NN
cord-006860-a3b8hyyr	3895	12	VII	VII	NNP
cord-006860-a3b8hyyr	3895	13	antigen	antigen	NN
cord-006860-a3b8hyyr	3895	14	(	(	-LRB-
cord-006860-a3b8hyyr	3895	15	VII	vii	NN
cord-006860-a3b8hyyr	3895	16	:	:	:
cord-006860-a3b8hyyr	3895	17	Ag	Ag	NNP
cord-006860-a3b8hyyr	3895	18	)	)	-RRB-
cord-006860-a3b8hyyr	3895	19	and	and	CC
cord-006860-a3b8hyyr	3896	1	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3896	2	ratio	ratio	NN
cord-006860-a3b8hyyr	3896	3	were	be	VBD
cord-006860-a3b8hyyr	3896	4	found	find	VBN
cord-006860-a3b8hyyr	3896	5	increased	increase	VBN
cord-006860-a3b8hyyr	3896	6	in	in	IN
cord-006860-a3b8hyyr	3896	7	hypothyroid	hypothyroid	JJ
cord-006860-a3b8hyyr	3896	8	patients	patient	NNS
cord-006860-a3b8hyyr	3896	9	.	.	.
cord-006860-a3b8hyyr	3897	1	Factor	factor	NN
cord-006860-a3b8hyyr	3897	2	VIII	VIII	NNP
cord-006860-a3b8hyyr	3897	3	activity	activity	NN
cord-006860-a3b8hyyr	3897	4	showed	show	VBD
cord-006860-a3b8hyyr	3897	5	the	the	DT
cord-006860-a3b8hyyr	3897	6	same	same	JJ
cord-006860-a3b8hyyr	3897	7	tendency	tendency	NN
cord-006860-a3b8hyyr	3897	8	,	,	,
cord-006860-a3b8hyyr	3897	9	whereas	whereas	IN
cord-006860-a3b8hyyr	3897	10	von	von	NNP
cord-006860-a3b8hyyr	3897	11	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	3897	12	factor	factor	NN
cord-006860-a3b8hyyr	3897	13	ramained	ramaine	VBD
cord-006860-a3b8hyyr	3897	14	unchanged	unchanged	JJ
cord-006860-a3b8hyyr	3897	15	,	,	,
cord-006860-a3b8hyyr	3897	16	as	as	IN
cord-006860-a3b8hyyr	3897	17	did	do	VBD
cord-006860-a3b8hyyr	3897	18	all	all	DT
cord-006860-a3b8hyyr	3897	19	other	other	JJ
cord-006860-a3b8hyyr	3897	20	parameters	parameter	NNS
cord-006860-a3b8hyyr	3897	21	with	with	IN
cord-006860-a3b8hyyr	3897	22	exception	exception	NN
cord-006860-a3b8hyyr	3897	23	of	of	IN
cord-006860-a3b8hyyr	3897	24	free	free	JJ
cord-006860-a3b8hyyr	3897	25	protein	protein	NN
cord-006860-a3b8hyyr	3897	26	S	S	NNP
cord-006860-a3b8hyyr	3897	27	,	,	,
cord-006860-a3b8hyyr	3897	28	which	which	WDT
cord-006860-a3b8hyyr	3897	29	declined	decline	VBD
cord-006860-a3b8hyyr	3897	30	in	in	IN
cord-006860-a3b8hyyr	3897	31	overt	overt	JJ
cord-006860-a3b8hyyr	3897	32	hypothyroidism	hypothyroidism	NN
cord-006860-a3b8hyyr	3897	33	and	and	CC
cord-006860-a3b8hyyr	3897	34	in	in	IN
cord-006860-a3b8hyyr	3897	35	T4	T4	NNP
cord-006860-a3b8hyyr	3897	36	treated	treat	VBD
cord-006860-a3b8hyyr	3897	37	subjects	subject	NNS
cord-006860-a3b8hyyr	3897	38	.	.	.
cord-006860-a3b8hyyr	3898	1	These	these	DT
cord-006860-a3b8hyyr	3898	2	differences	difference	NNS
cord-006860-a3b8hyyr	3898	3	tended	tend	VBD
cord-006860-a3b8hyyr	3898	4	to	to	TO
cord-006860-a3b8hyyr	3898	5	diminish	diminish	VB
cord-006860-a3b8hyyr	3898	6	after	after	IN
cord-006860-a3b8hyyr	3898	7	exclusion	exclusion	NN
cord-006860-a3b8hyyr	3898	8	of	of	IN
cord-006860-a3b8hyyr	3898	9	26	26	CD
cord-006860-a3b8hyyr	3898	10	women	woman	NNS
cord-006860-a3b8hyyr	3898	11	with	with	IN
cord-006860-a3b8hyyr	3898	12	estrogen	estrogen	NN
cord-006860-a3b8hyyr	3898	13	replacement	replacement	NN
cord-006860-a3b8hyyr	3898	14	therapy	therapy	NN
cord-006860-a3b8hyyr	3898	15	for	for	IN
cord-006860-a3b8hyyr	3898	16	menopause	menopause	NN
cord-006860-a3b8hyyr	3898	17	,	,	,
cord-006860-a3b8hyyr	3898	18	but	but	CC
cord-006860-a3b8hyyr	3898	19	the	the	DT
cord-006860-a3b8hyyr	3898	20	ratio	ratio	NN
cord-006860-a3b8hyyr	3898	21	VII	vii	NN
cord-006860-a3b8hyyr	3898	22	:	:	:
cord-006860-a3b8hyyr	3898	23	CNII	CNII	NNP
cord-006860-a3b8hyyr	3898	24	:	:	:
cord-006860-a3b8hyyr	3899	1	Ag	Ag	NNP
cord-006860-a3b8hyyr	3899	2	,	,	,
cord-006860-a3b8hyyr	3899	3	as	as	RB
cord-006860-a3b8hyyr	3899	4	well	well	RB
cord-006860-a3b8hyyr	3899	5	as	as	IN
cord-006860-a3b8hyyr	3899	6	FVII	FVII	NNP
cord-006860-a3b8hyyr	3899	7	:	:	:
cord-006860-a3b8hyyr	3899	8	C	C	NNP
cord-006860-a3b8hyyr	3899	9	still	still	RB
cord-006860-a3b8hyyr	3899	10	remained	remain	VBD
cord-006860-a3b8hyyr	3899	11	significantly	significantly	RB
cord-006860-a3b8hyyr	3899	12	higher	high	JJR
cord-006860-a3b8hyyr	3899	13	in	in	IN
cord-006860-a3b8hyyr	3899	14	hypothyroid	hypothyroid	JJ
cord-006860-a3b8hyyr	3899	15	patients	patient	NNS
cord-006860-a3b8hyyr	3899	16	.	.	.
cord-006860-a3b8hyyr	3900	1	Conclusions	conclusion	NNS
cord-006860-a3b8hyyr	3900	2	:	:	:
cord-006860-a3b8hyyr	3901	1	Subclinical	subclinical	JJ
cord-006860-a3b8hyyr	3901	2	and	and	CC
cord-006860-a3b8hyyr	3901	3	overt	overt	JJ
cord-006860-a3b8hyyr	3901	4	hypothyroidism	hypothyroidism	NN
cord-006860-a3b8hyyr	3901	5	are	be	VBP
cord-006860-a3b8hyyr	3901	6	associated	associate	VBN
cord-006860-a3b8hyyr	3901	7	with	with	IN
cord-006860-a3b8hyyr	3901	8	significantly	significantly	RB
cord-006860-a3b8hyyr	3901	9	higher	high	JJR
cord-006860-a3b8hyyr	3901	10	levels	level	NNS
cord-006860-a3b8hyyr	3901	11	of	of	IN
cord-006860-a3b8hyyr	3901	12	factor	factor	NN
cord-006860-a3b8hyyr	3901	13	VII	vii	NN
cord-006860-a3b8hyyr	3901	14	:	:	:
cord-006860-a3b8hyyr	3901	15	C	C	NNP
cord-006860-a3b8hyyr	3901	16	and	and	CC
cord-006860-a3b8hyyr	3901	17	VII	vii	NN
cord-006860-a3b8hyyr	3901	18	:	:	:
cord-006860-a3b8hyyr	3901	19	Ag	Ag	NNP
cord-006860-a3b8hyyr	3901	20	.	.	.
cord-006860-a3b8hyyr	3902	1	The	the	DT
cord-006860-a3b8hyyr	3902	2	disproportionate	disproportionate	JJ
cord-006860-a3b8hyyr	3902	3	increase	increase	NN
cord-006860-a3b8hyyr	3902	4	in	in	IN
cord-006860-a3b8hyyr	3902	5	VII	vii	NN
cord-006860-a3b8hyyr	3902	6	:	:	:
cord-006860-a3b8hyyr	3903	1	C	c	NN
cord-006860-a3b8hyyr	3903	2	compared	compare	VBN
cord-006860-a3b8hyyr	3903	3	to	to	IN
cord-006860-a3b8hyyr	3903	4	Vll	Vll	NNP
cord-006860-a3b8hyyr	3903	5	:	:	:
cord-006860-a3b8hyyr	3904	1	Ag	Ag	NNP
cord-006860-a3b8hyyr	3904	2	,	,	,
cord-006860-a3b8hyyr	3904	3	as	as	IN
cord-006860-a3b8hyyr	3904	4	shown	show	VBN
cord-006860-a3b8hyyr	3904	5	by	by	IN
cord-006860-a3b8hyyr	3904	6	their	-PRON-	PRP$
cord-006860-a3b8hyyr	3904	7	ratio	ratio	NN
cord-006860-a3b8hyyr	3904	8	,	,	,
cord-006860-a3b8hyyr	3904	9	might	may	MD
cord-006860-a3b8hyyr	3904	10	reflect	reflect	VB
cord-006860-a3b8hyyr	3904	11	the	the	DT
cord-006860-a3b8hyyr	3904	12	presence	presence	NN
cord-006860-a3b8hyyr	3904	13	of	of	IN
cord-006860-a3b8hyyr	3904	14	activated	activate	VBN
cord-006860-a3b8hyyr	3904	15	factor	factor	NN
cord-006860-a3b8hyyr	3904	16	VII	VII	NNP
cord-006860-a3b8hyyr	3904	17	(	(	-LRB-
cord-006860-a3b8hyyr	3904	18	VIla	VIla	NNP
cord-006860-a3b8hyyr	3904	19	)	)	-RRB-
cord-006860-a3b8hyyr	3904	20	,	,	,
cord-006860-a3b8hyyr	3904	21	which	which	WDT
cord-006860-a3b8hyyr	3904	22	in	in	IN
cord-006860-a3b8hyyr	3904	23	turn	turn	NN
cord-006860-a3b8hyyr	3904	24	indicates	indicate	VBZ
cord-006860-a3b8hyyr	3904	25	a	a	DT
cord-006860-a3b8hyyr	3904	26	hypercoagulable	hypercoagulable	JJ
cord-006860-a3b8hyyr	3904	27	state	state	NN
cord-006860-a3b8hyyr	3904	28	.	.	.
cord-006860-a3b8hyyr	3905	1	This	this	DT
cord-006860-a3b8hyyr	3905	2	pattern	pattern	NN
cord-006860-a3b8hyyr	3905	3	becomes	become	VBZ
cord-006860-a3b8hyyr	3905	4	more	more	RBR
cord-006860-a3b8hyyr	3905	5	pronounced	pronounced	JJ
cord-006860-a3b8hyyr	3905	6	with	with	IN
cord-006860-a3b8hyyr	3905	7	the	the	DT
cord-006860-a3b8hyyr	3905	8	concomitant	concomitant	JJ
cord-006860-a3b8hyyr	3905	9	estrogen	estrogen	NN
cord-006860-a3b8hyyr	3905	10	replacement	replacement	NN
cord-006860-a3b8hyyr	3905	11	after	after	IN
cord-006860-a3b8hyyr	3905	12	menopause	menopause	NN
cord-006860-a3b8hyyr	3905	13	.	.	.
cord-006860-a3b8hyyr	3906	1	Exocytosis	exocytosis	NN
cord-006860-a3b8hyyr	3906	2	following	follow	VBG
cord-006860-a3b8hyyr	3906	3	platelet	platelet	NN
cord-006860-a3b8hyyr	3906	4	activation	activation	NN
cord-006860-a3b8hyyr	3906	5	leads	lead	VBZ
cord-006860-a3b8hyyr	3906	6	to	to	IN
cord-006860-a3b8hyyr	3906	7	translocation	translocation	NN
cord-006860-a3b8hyyr	3906	8	of	of	IN
cord-006860-a3b8hyyr	3906	9	CD62P	cd62p	NN
cord-006860-a3b8hyyr	3907	1	(	(	-LRB-
cord-006860-a3b8hyyr	3907	2	P	p	NN
cord-006860-a3b8hyyr	3907	3	-	-	HYPH
cord-006860-a3b8hyyr	3907	4	selectin	selectin	NNP
cord-006860-a3b8hyyr	3907	5	)	)	-RRB-
cord-006860-a3b8hyyr	3907	6	,	,	,
cord-006860-a3b8hyyr	3907	7	CD63	CD63	NNP
cord-006860-a3b8hyyr	3907	8	,	,	,
cord-006860-a3b8hyyr	3907	9	and	and	CC
cord-006860-a3b8hyyr	3907	10	thrombospondin	thrombospondin	NNP
cord-006860-a3b8hyyr	3907	11	,	,	,
cord-006860-a3b8hyyr	3907	12	from	from	IN
cord-006860-a3b8hyyr	3907	13	cytoplasmic	cytoplasmic	JJ
cord-006860-a3b8hyyr	3907	14	granules	granule	NNS
cord-006860-a3b8hyyr	3907	15	to	to	IN
cord-006860-a3b8hyyr	3907	16	the	the	DT
cord-006860-a3b8hyyr	3907	17	cell	cell	NN
cord-006860-a3b8hyyr	3907	18	surface	surface	NN
cord-006860-a3b8hyyr	3907	19	membrane	membrane	NN
cord-006860-a3b8hyyr	3907	20	,	,	,
cord-006860-a3b8hyyr	3907	21	where	where	WRB
cord-006860-a3b8hyyr	3907	22	these	these	DT
cord-006860-a3b8hyyr	3907	23	molecules	molecule	NNS
cord-006860-a3b8hyyr	3907	24	,	,	,
cord-006860-a3b8hyyr	3907	25	serving	serve	VBG
cord-006860-a3b8hyyr	3907	26	as	as	IN
cord-006860-a3b8hyyr	3907	27	activation	activation	NN
cord-006860-a3b8hyyr	3907	28	markers	marker	NNS
cord-006860-a3b8hyyr	3907	29	,	,	,
cord-006860-a3b8hyyr	3907	30	can	can	MD
cord-006860-a3b8hyyr	3907	31	be	be	VB
cord-006860-a3b8hyyr	3907	32	detected	detect	VBN
cord-006860-a3b8hyyr	3907	33	by	by	IN
cord-006860-a3b8hyyr	3907	34	flow	flow	NN
cord-006860-a3b8hyyr	3907	35	cytometry	cytometry	NN
cord-006860-a3b8hyyr	3907	36	.	.	.
cord-006860-a3b8hyyr	3908	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3908	2	here	here	RB
cord-006860-a3b8hyyr	3908	3	report	report	VBP
cord-006860-a3b8hyyr	3908	4	detectability	detectability	NN
cord-006860-a3b8hyyr	3908	5	of	of	IN
cord-006860-a3b8hyyr	3908	6	these	these	DT
cord-006860-a3b8hyyr	3908	7	molecules	molecule	NNS
cord-006860-a3b8hyyr	3908	8	preformedprior	preformedprior	JJ
cord-006860-a3b8hyyr	3908	9	to	to	IN
cord-006860-a3b8hyyr	3908	10	platelet	platelet	NN
cord-006860-a3b8hyyr	3908	11	activation	activation	NN
cord-006860-a3b8hyyr	3908	12	-inside	-inside	RB
cord-006860-a3b8hyyr	3909	1	the	the	DT
cord-006860-a3b8hyyr	3909	2	cytoplasm	cytoplasm	NN
cord-006860-a3b8hyyr	3909	3	of	of	IN
cord-006860-a3b8hyyr	3909	4	resting	rest	VBG
cord-006860-a3b8hyyr	3909	5	platelets	platelet	NNS
cord-006860-a3b8hyyr	3909	6	.	.	.
cord-006860-a3b8hyyr	3910	1	Two	two	CD
cord-006860-a3b8hyyr	3910	2	different	different	JJ
cord-006860-a3b8hyyr	3910	3	methods	method	NNS
cord-006860-a3b8hyyr	3910	4	are	be	VBP
cord-006860-a3b8hyyr	3910	5	compared	compare	VBN
cord-006860-a3b8hyyr	3910	6	,	,	,
cord-006860-a3b8hyyr	3910	7	i.	i.	NNP
cord-006860-a3b8hyyr	3910	8	e.	e.	NNP
cord-006860-a3b8hyyr	3910	9	using	use	VBG
cord-006860-a3b8hyyr	3910	10	either	either	CC
cord-006860-a3b8hyyr	3910	11	methanol	methanol	NN
cord-006860-a3b8hyyr	3910	12	or	or	CC
cord-006860-a3b8hyyr	3910	13	the	the	DT
cord-006860-a3b8hyyr	3910	14	Fix&Perm	Fix&Perm	NNP
cord-006860-a3b8hyyr	3910	15	kit	kit	NN
cord-006860-a3b8hyyr	3910	16	(	(	-LRB-
cord-006860-a3b8hyyr	3910	17	An	an	DT
cord-006860-a3b8hyyr	3910	18	der	der	NN
cord-006860-a3b8hyyr	3910	19	Grub	Grub	NNP
cord-006860-a3b8hyyr	3910	20	)	)	-RRB-
cord-006860-a3b8hyyr	3910	21	for	for	IN
cord-006860-a3b8hyyr	3910	22	cell	cell	NN
cord-006860-a3b8hyyr	3910	23	membrane	membrane	NN
cord-006860-a3b8hyyr	3910	24	permeabilization	permeabilization	NN
cord-006860-a3b8hyyr	3910	25	.	.	.
cord-006860-a3b8hyyr	3911	1	In	in	IN
cord-006860-a3b8hyyr	3911	2	addition	addition	NN
cord-006860-a3b8hyyr	3911	3	,	,	,
cord-006860-a3b8hyyr	3911	4	interleukin(IL)-Ice	interleukin(IL)-Ice	NNP
cord-006860-a3b8hyyr	3911	5	is	be	VBZ
cord-006860-a3b8hyyr	3911	6	shown	show	VBN
cord-006860-a3b8hyyr	3911	7	to	to	TO
cord-006860-a3b8hyyr	3911	8	be	be	VB
cord-006860-a3b8hyyr	3911	9	present	present	JJ
cord-006860-a3b8hyyr	3911	10	in	in	IN
cord-006860-a3b8hyyr	3911	11	platelet	platelet	NN
cord-006860-a3b8hyyr	3911	12	cytoplasm	cytoplasm	NN
cord-006860-a3b8hyyr	3911	13	after	after	IN
cord-006860-a3b8hyyr	3911	14	methanol	methanol	NN
cord-006860-a3b8hyyr	3911	15	treatment	treatment	NN
cord-006860-a3b8hyyr	3911	16	,	,	,
cord-006860-a3b8hyyr	3911	17	but	but	CC
cord-006860-a3b8hyyr	3911	18	not	not	RB
cord-006860-a3b8hyyr	3911	19	after	after	IN
cord-006860-a3b8hyyr	3911	20	permeabilization	permeabilization	NN
cord-006860-a3b8hyyr	3911	21	using	use	VBG
cord-006860-a3b8hyyr	3911	22	Fix&Perm	Fix&Perm	NNP
cord-006860-a3b8hyyr	3911	23	.	.	.
cord-006860-a3b8hyyr	3912	1	Whenever	whenever	WRB
cord-006860-a3b8hyyr	3912	2	cell	cell	NN
cord-006860-a3b8hyyr	3912	3	surface	surface	NN
cord-006860-a3b8hyyr	3912	4	positivity	positivity	NN
cord-006860-a3b8hyyr	3912	5	for	for	IN
cord-006860-a3b8hyyr	3912	6	a	a	DT
cord-006860-a3b8hyyr	3912	7	specific	specific	JJ
cord-006860-a3b8hyyr	3912	8	marker	marker	NN
cord-006860-a3b8hyyr	3912	9	coincides	coincide	VBZ
cord-006860-a3b8hyyr	3912	10	with	with	IN
cord-006860-a3b8hyyr	3912	11	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	3912	12	presence	presence	NN
cord-006860-a3b8hyyr	3912	13	,	,	,
cord-006860-a3b8hyyr	3912	14	blocking	block	VBG
cord-006860-a3b8hyyr	3912	15	of	of	IN
cord-006860-a3b8hyyr	3912	16	the	the	DT
cord-006860-a3b8hyyr	3912	17	surface	surface	NN
cord-006860-a3b8hyyr	3912	18	membrane	membrane	NN
cord-006860-a3b8hyyr	3912	19	sites	site	NNS
cord-006860-a3b8hyyr	3912	20	prior	prior	RB
cord-006860-a3b8hyyr	3912	21	to	to	IN
cord-006860-a3b8hyyr	3912	22	membrane	membrane	NN
cord-006860-a3b8hyyr	3912	23	permeabilization	permeabilization	NN
cord-006860-a3b8hyyr	3912	24	is	be	VBZ
cord-006860-a3b8hyyr	3912	25	required	require	VBN
cord-006860-a3b8hyyr	3912	26	in	in	IN
cord-006860-a3b8hyyr	3912	27	order	order	NN
cord-006860-a3b8hyyr	3912	28	to	to	TO
cord-006860-a3b8hyyr	3912	29	obtain	obtain	VB
cord-006860-a3b8hyyr	3912	30	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	3912	31	intensity	intensity	NN
cord-006860-a3b8hyyr	3912	32	attributable	attributable	JJ
cord-006860-a3b8hyyr	3912	33	to	to	IN
cord-006860-a3b8hyyr	3912	34	cytoplasmic	cytoplasmic	JJ
cord-006860-a3b8hyyr	3912	35	staining	staining	NN
cord-006860-a3b8hyyr	3912	36	.	.	.
cord-006860-a3b8hyyr	3913	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	3913	2	data	datum	NNS
cord-006860-a3b8hyyr	3913	3	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	3913	4	the	the	DT
cord-006860-a3b8hyyr	3913	5	feasibility	feasibility	NN
cord-006860-a3b8hyyr	3913	6	of	of	IN
cord-006860-a3b8hyyr	3913	7	the	the	DT
cord-006860-a3b8hyyr	3913	8	methods	method	NNS
cord-006860-a3b8hyyr	3913	9	presented	present	VBN
cord-006860-a3b8hyyr	3913	10	for	for	IN
cord-006860-a3b8hyyr	3913	11	the	the	DT
cord-006860-a3b8hyyr	3913	12	detection	detection	NN
cord-006860-a3b8hyyr	3913	13	of	of	IN
cord-006860-a3b8hyyr	3913	14	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	3913	15	platelet	platelet	NN
cord-006860-a3b8hyyr	3913	16	molecules	molecule	NNS
cord-006860-a3b8hyyr	3913	17	.	.	.
cord-006860-a3b8hyyr	3914	1	This	this	DT
cord-006860-a3b8hyyr	3914	2	technique	technique	NN
cord-006860-a3b8hyyr	3914	3	should	should	MD
cord-006860-a3b8hyyr	3914	4	also	also	RB
cord-006860-a3b8hyyr	3914	5	provide	provide	VB
cord-006860-a3b8hyyr	3914	6	a	a	DT
cord-006860-a3b8hyyr	3914	7	means	means	NN
cord-006860-a3b8hyyr	3914	8	for	for	IN
cord-006860-a3b8hyyr	3914	9	estimating	estimate	VBG
cord-006860-a3b8hyyr	3914	10	the	the	DT
cord-006860-a3b8hyyr	3914	11	relative	relative	JJ
cord-006860-a3b8hyyr	3914	12	quantity	quantity	NN
cord-006860-a3b8hyyr	3914	13	of	of	IN
cord-006860-a3b8hyyr	3914	14	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	3914	15	platelet	platelet	NN
cord-006860-a3b8hyyr	3914	16	antigens	antigen	NNS
cord-006860-a3b8hyyr	3914	17	,	,	,
cord-006860-a3b8hyyr	3914	18	provided	provide	VBD
cord-006860-a3b8hyyr	3914	19	the	the	DT
cord-006860-a3b8hyyr	3914	20	permeabilization	permeabilization	NN
cord-006860-a3b8hyyr	3914	21	procedure	procedure	NN
cord-006860-a3b8hyyr	3914	22	does	do	VBZ
cord-006860-a3b8hyyr	3914	23	not	not	RB
cord-006860-a3b8hyyr	3914	24	lead	lead	VB
cord-006860-a3b8hyyr	3914	25	to	to	IN
cord-006860-a3b8hyyr	3914	26	antigen	antigen	NN
cord-006860-a3b8hyyr	3914	27	leakage	leakage	NN
cord-006860-a3b8hyyr	3914	28	or	or	CC
cord-006860-a3b8hyyr	3914	29	destruction	destruction	NN
cord-006860-a3b8hyyr	3914	30	.	.	.
cord-006860-a3b8hyyr	3915	1	Physical	physical	JJ
cord-006860-a3b8hyyr	3915	2	exercise	exercise	NN
cord-006860-a3b8hyyr	3915	3	activates	activate	VBZ
cord-006860-a3b8hyyr	3915	4	the	the	DT
cord-006860-a3b8hyyr	3915	5	clotting	clotting	NN
cord-006860-a3b8hyyr	3915	6	as	as	RB
cord-006860-a3b8hyyr	3915	7	well	well	RB
cord-006860-a3b8hyyr	3915	8	as	as	IN
cord-006860-a3b8hyyr	3915	9	the	the	DT
cord-006860-a3b8hyyr	3915	10	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	3915	11	system	system	NN
cord-006860-a3b8hyyr	3915	12	as	as	IN
cord-006860-a3b8hyyr	3915	13	indicated	indicate	VBN
cord-006860-a3b8hyyr	3915	14	in	in	IN
cord-006860-a3b8hyyr	3915	15	numerous	numerous	JJ
cord-006860-a3b8hyyr	3915	16	investigations	investigation	NNS
cord-006860-a3b8hyyr	3915	17	of	of	IN
cord-006860-a3b8hyyr	3915	18	exercise	exercise	NN
cord-006860-a3b8hyyr	3915	19	by	by	IN
cord-006860-a3b8hyyr	3915	20	running	run	VBG
cord-006860-a3b8hyyr	3915	21	and	and	CC
cord-006860-a3b8hyyr	3915	22	by	by	IN
cord-006860-a3b8hyyr	3915	23	bicycle	bicycle	NN
cord-006860-a3b8hyyr	3915	24	ergometer	ergometer	NN
cord-006860-a3b8hyyr	3915	25	but	but	CC
cord-006860-a3b8hyyr	3915	26	not	not	RB
cord-006860-a3b8hyyr	3915	27	by	by	IN
cord-006860-a3b8hyyr	3915	28	swimming	swim	VBG
cord-006860-a3b8hyyr	3915	29	.	.	.
cord-006860-a3b8hyyr	3916	1	The	the	DT
cord-006860-a3b8hyyr	3916	2	positive	positive	JJ
cord-006860-a3b8hyyr	3916	3	effect	effect	NN
cord-006860-a3b8hyyr	3916	4	of	of	IN
cord-006860-a3b8hyyr	3916	5	an	an	DT
cord-006860-a3b8hyyr	3916	6	endurance	endurance	NN
cord-006860-a3b8hyyr	3916	7	training	training	NN
cord-006860-a3b8hyyr	3916	8	in	in	IN
cord-006860-a3b8hyyr	3916	9	coronary	coronary	JJ
cord-006860-a3b8hyyr	3916	10	sport	sport	NN
cord-006860-a3b8hyyr	3916	11	groups	group	NNS
cord-006860-a3b8hyyr	3916	12	is	be	VBZ
cord-006860-a3b8hyyr	3916	13	induced	induce	VBN
cord-006860-a3b8hyyr	3916	14	also	also	RB
cord-006860-a3b8hyyr	3916	15	by	by	IN
cord-006860-a3b8hyyr	3916	16	influences	influence	NNS
cord-006860-a3b8hyyr	3916	17	on	on	IN
cord-006860-a3b8hyyr	3916	18	the	the	DT
cord-006860-a3b8hyyr	3916	19	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	3916	20	system	system	NN
cord-006860-a3b8hyyr	3916	21	.	.	.
cord-006860-a3b8hyyr	3917	1	The	the	DT
cord-006860-a3b8hyyr	3917	2	influences	influence	NNS
cord-006860-a3b8hyyr	3917	3	are	be	VBP
cord-006860-a3b8hyyr	3917	4	suppression	suppression	NN
cord-006860-a3b8hyyr	3917	5	of	of	IN
cord-006860-a3b8hyyr	3917	6	the	the	DT
cord-006860-a3b8hyyr	3917	7	clotting	clotting	NN
cord-006860-a3b8hyyr	3917	8	activation	activation	NN
cord-006860-a3b8hyyr	3917	9	by	by	IN
cord-006860-a3b8hyyr	3917	10	the	the	DT
cord-006860-a3b8hyyr	3917	11	acute	acute	JJ
cord-006860-a3b8hyyr	3917	12	exercise	exercise	NN
cord-006860-a3b8hyyr	3917	13	and	and	CC
cord-006860-a3b8hyyr	3917	14	by	by	IN
cord-006860-a3b8hyyr	3917	15	an	an	DT
cord-006860-a3b8hyyr	3917	16	increased	increase	VBN
cord-006860-a3b8hyyr	3917	17	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	3917	18	response	response	NN
cord-006860-a3b8hyyr	3917	19	.	.	.
cord-006860-a3b8hyyr	3918	1	Different	different	JJ
cord-006860-a3b8hyyr	3918	2	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	3918	3	parameters	parameter	NNS
cord-006860-a3b8hyyr	3918	4	,	,	,
cord-006860-a3b8hyyr	3918	5	therefore	therefore	RB
cord-006860-a3b8hyyr	3918	6	,	,	,
cord-006860-a3b8hyyr	3918	7	were	be	VBD
cord-006860-a3b8hyyr	3918	8	analyzed	analyze	VBN
cord-006860-a3b8hyyr	3918	9	before	before	RB
cord-006860-a3b8hyyr	3918	10	and	and	CC
cord-006860-a3b8hyyr	3918	11	after	after	IN
cord-006860-a3b8hyyr	3918	12	swimming	swimming	NN
cord-006860-a3b8hyyr	3918	13	of	of	IN
cord-006860-a3b8hyyr	3918	14	male	male	JJ
cord-006860-a3b8hyyr	3918	15	coronary	coronary	JJ
cord-006860-a3b8hyyr	3918	16	patients	patient	NNS
cord-006860-a3b8hyyr	3918	17	(	(	-LRB-
cord-006860-a3b8hyyr	3918	18	n=33	n=33	NNP
cord-006860-a3b8hyyr	3918	19	;	;	:
cord-006860-a3b8hyyr	3918	20	median	median	NN
cord-006860-a3b8hyyr	3918	21	ag~	ag~	NN
cord-006860-a3b8hyyr	3918	22	61	61	CD
cord-006860-a3b8hyyr	3918	23	years	year	NNS
cord-006860-a3b8hyyr	3918	24	,	,	,
cord-006860-a3b8hyyr	3918	25	achieved	achieve	VBD
cord-006860-a3b8hyyr	3918	26	heart	heart	NN
cord-006860-a3b8hyyr	3918	27	rate	rate	NN
cord-006860-a3b8hyyr	3918	28	:	:	:
cord-006860-a3b8hyyr	3918	29	68	68	CD
cord-006860-a3b8hyyr	3918	30	/	/	SYM
cord-006860-a3b8hyyr	3918	31	min	min	NN
cord-006860-a3b8hyyr	3918	32	)	)	-RRB-
cord-006860-a3b8hyyr	3918	33	.	.	.
cord-006860-a3b8hyyr	3919	1	Indicating	indicate	VBG
cord-006860-a3b8hyyr	3919	2	plasmatic	plasmatic	JJ
cord-006860-a3b8hyyr	3919	3	clotting	clotting	NN
cord-006860-a3b8hyyr	3919	4	activation	activation	NN
cord-006860-a3b8hyyr	3919	5	there	there	EX
cord-006860-a3b8hyyr	3919	6	was	be	VBD
cord-006860-a3b8hyyr	3919	7	a	a	DT
cord-006860-a3b8hyyr	3919	8	significant	significant	JJ
cord-006860-a3b8hyyr	3919	9	increase	increase	NN
cord-006860-a3b8hyyr	3919	10	in	in	IN
cord-006860-a3b8hyyr	3919	11	molecular	molecular	JJ
cord-006860-a3b8hyyr	3919	12	markers	marker	NNS
cord-006860-a3b8hyyr	3919	13	TAT	TAT	NNP
cord-006860-a3b8hyyr	3919	14	and	and	CC
cord-006860-a3b8hyyr	3919	15	F1	f1	NN
cord-006860-a3b8hyyr	3919	16	+	+	CC
cord-006860-a3b8hyyr	3920	1	2	2	LS
cord-006860-a3b8hyyr	3920	2	among	among	IN
cord-006860-a3b8hyyr	3920	3	the	the	DT
cord-006860-a3b8hyyr	3920	4	coronary	coronary	JJ
cord-006860-a3b8hyyr	3920	5	patients	patient	NNS
cord-006860-a3b8hyyr	3921	1	(	(	-LRB-
cord-006860-a3b8hyyr	3921	2	TAT	tat	NN
cord-006860-a3b8hyyr	3921	3	from	from	IN
cord-006860-a3b8hyyr	3921	4	2,1	2,1	CD
cord-006860-a3b8hyyr	3921	5	to	to	IN
cord-006860-a3b8hyyr	3921	6	3,4	3,4	CD
cord-006860-a3b8hyyr	3921	7	pg/1	pg/1	NN
cord-006860-a3b8hyyr	3922	1	;	;	:
cord-006860-a3b8hyyr	3922	2	FI+2	FI+2	NNP
cord-006860-a3b8hyyr	3922	3	from	from	IN
cord-006860-a3b8hyyr	3922	4	0,92	0,92	NNS
cord-006860-a3b8hyyr	3922	5	to	to	IN
cord-006860-a3b8hyyr	3922	6	1,1	1,1	CD
cord-006860-a3b8hyyr	3923	1	nmol/1	nmol/1	NNP
cord-006860-a3b8hyyr	3923	2	)	)	-RRB-
cord-006860-a3b8hyyr	3923	3	.	.	.
cord-006860-a3b8hyyr	3924	1	The	the	DT
cord-006860-a3b8hyyr	3924	2	degree	degree	NN
cord-006860-a3b8hyyr	3924	3	of	of	IN
cord-006860-a3b8hyyr	3924	4	clotting	clotting	NN
cord-006860-a3b8hyyr	3924	5	activation	activation	NN
cord-006860-a3b8hyyr	3924	6	among	among	IN
cord-006860-a3b8hyyr	3924	7	the	the	DT
cord-006860-a3b8hyyr	3924	8	coronary	coronary	JJ
cord-006860-a3b8hyyr	3924	9	patients	patient	NNS
cord-006860-a3b8hyyr	3924	10	was	be	VBD
cord-006860-a3b8hyyr	3924	11	less	less	JJR
cord-006860-a3b8hyyr	3924	12	than	than	IN
cord-006860-a3b8hyyr	3924	13	that	that	DT
cord-006860-a3b8hyyr	3924	14	observed	observe	VBD
cord-006860-a3b8hyyr	3924	15	in	in	IN
cord-006860-a3b8hyyr	3924	16	a	a	DT
cord-006860-a3b8hyyr	3924	17	group	group	NN
cord-006860-a3b8hyyr	3924	18	of	of	IN
cord-006860-a3b8hyyr	3924	19	young	young	JJ
cord-006860-a3b8hyyr	3924	20	volunteers	volunteer	NNS
cord-006860-a3b8hyyr	3924	21	in	in	IN
cord-006860-a3b8hyyr	3924	22	a	a	DT
cord-006860-a3b8hyyr	3924	23	former	former	JJ
cord-006860-a3b8hyyr	3924	24	investigation	investigation	NN
cord-006860-a3b8hyyr	3924	25	.	.	.
cord-006860-a3b8hyyr	3925	1	This	this	DT
cord-006860-a3b8hyyr	3925	2	must	must	MD
cord-006860-a3b8hyyr	3925	3	be	be	VB
cord-006860-a3b8hyyr	3925	4	explained	explain	VBN
cord-006860-a3b8hyyr	3925	5	by	by	IN
cord-006860-a3b8hyyr	3925	6	existence	existence	NN
cord-006860-a3b8hyyr	3925	7	of	of	IN
cord-006860-a3b8hyyr	3925	8	the	the	DT
cord-006860-a3b8hyyr	3925	9	coronary	coronary	JJ
cord-006860-a3b8hyyr	3925	10	heart	heart	NN
cord-006860-a3b8hyyr	3925	11	disease	disease	NN
cord-006860-a3b8hyyr	3925	12	or	or	CC
cord-006860-a3b8hyyr	3925	13	by	by	IN
cord-006860-a3b8hyyr	3925	14	the	the	DT
cord-006860-a3b8hyyr	3925	15	higher	high	JJR
cord-006860-a3b8hyyr	3925	16	age	age	NN
cord-006860-a3b8hyyr	3925	17	in	in	IN
cord-006860-a3b8hyyr	3925	18	the	the	DT
cord-006860-a3b8hyyr	3925	19	patient	patient	NN
cord-006860-a3b8hyyr	3925	20	group	group	NN
cord-006860-a3b8hyyr	3925	21	.	.	.
cord-006860-a3b8hyyr	3926	1	Indicating	indicate	VBG
cord-006860-a3b8hyyr	3926	2	an	an	DT
cord-006860-a3b8hyyr	3926	3	activation	activation	NN
cord-006860-a3b8hyyr	3926	4	of	of	IN
cord-006860-a3b8hyyr	3926	5	fibrinolysis	fibrinolysis	NNP
cord-006860-a3b8hyyr	3926	6	t	t	NNP
cord-006860-a3b8hyyr	3926	7	-	-	HYPH
cord-006860-a3b8hyyr	3926	8	PA	PA	NNP
cord-006860-a3b8hyyr	3926	9	activity	activity	NN
cord-006860-a3b8hyyr	3926	10	increased	increase	VBD
cord-006860-a3b8hyyr	3926	11	significantly	significantly	RB
cord-006860-a3b8hyyr	3926	12	in	in	IN
cord-006860-a3b8hyyr	3926	13	coronary	coronary	JJ
cord-006860-a3b8hyyr	3926	14	patients	patient	NNS
cord-006860-a3b8hyyr	3926	15	(	(	-LRB-
cord-006860-a3b8hyyr	3926	16	from	from	IN
cord-006860-a3b8hyyr	3926	17	0,14	0,14	CD
cord-006860-a3b8hyyr	3926	18	to	to	IN
cord-006860-a3b8hyyr	3926	19	0,5	0,5	CD
cord-006860-a3b8hyyr	3926	20	IU	IU	NNP
cord-006860-a3b8hyyr	3926	21	/	/	SYM
cord-006860-a3b8hyyr	3926	22	ml	ml	NN
cord-006860-a3b8hyyr	3926	23	)	)	-RRB-
cord-006860-a3b8hyyr	3926	24	resulting	result	VBG
cord-006860-a3b8hyyr	3926	25	in	in	IN
cord-006860-a3b8hyyr	3926	26	an	an	DT
cord-006860-a3b8hyyr	3926	27	unchanged	unchanged	JJ
cord-006860-a3b8hyyr	3926	28	balance	balance	NN
cord-006860-a3b8hyyr	3926	29	between	between	IN
cord-006860-a3b8hyyr	3926	30	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3926	31	and	and	CC
cord-006860-a3b8hyyr	3926	32	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	3926	33	.	.	.
cord-006860-a3b8hyyr	3927	1	From	from	IN
cord-006860-a3b8hyyr	3927	2	this	this	DT
cord-006860-a3b8hyyr	3927	3	findings	finding	NNS
cord-006860-a3b8hyyr	3927	4	of	of	IN
cord-006860-a3b8hyyr	3927	5	the	the	DT
cord-006860-a3b8hyyr	3927	6	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	3927	7	systems	system	NNS
cord-006860-a3b8hyyr	3927	8	no	no	DT
cord-006860-a3b8hyyr	3927	9	increased	increase	VBN
cord-006860-a3b8hyyr	3927	10	risk	risk	NN
cord-006860-a3b8hyyr	3927	11	of	of	IN
cord-006860-a3b8hyyr	3927	12	the	the	DT
cord-006860-a3b8hyyr	3927	13	coronary	coronary	JJ
cord-006860-a3b8hyyr	3927	14	patients	patient	NNS
cord-006860-a3b8hyyr	3927	15	by	by	IN
cord-006860-a3b8hyyr	3927	16	swimming	swimming	NN
cord-006860-a3b8hyyr	3927	17	can	can	MD
cord-006860-a3b8hyyr	3927	18	be	be	VB
cord-006860-a3b8hyyr	3927	19	derived	derive	VBN
cord-006860-a3b8hyyr	3927	20	.	.	.
cord-006860-a3b8hyyr	3928	1	A	a	DT
cord-006860-a3b8hyyr	3928	2	prerequisite	prerequisite	NN
cord-006860-a3b8hyyr	3928	3	,	,	,
cord-006860-a3b8hyyr	3928	4	however	however	RB
cord-006860-a3b8hyyr	3928	5	,	,	,
cord-006860-a3b8hyyr	3928	6	are	be	VBP
cord-006860-a3b8hyyr	3928	7	precautions	precaution	NNS
cord-006860-a3b8hyyr	3928	8	l±ke	l±ke	IN
cord-006860-a3b8hyyr	3928	9	to	to	TO
cord-006860-a3b8hyyr	3928	10	devoid	devoid	JJ
cord-006860-a3b8hyyr	3928	11	exercise	exercise	NN
cord-006860-a3b8hyyr	3928	12	in	in	IN
cord-006860-a3b8hyyr	3928	13	the	the	DT
cord-006860-a3b8hyyr	3928	14	anaerobic	anaerobic	JJ
cord-006860-a3b8hyyr	3928	15	range	range	NN
cord-006860-a3b8hyyr	3928	16	,	,	,
cord-006860-a3b8hyyr	3928	17	exclusion	exclusion	NN
cord-006860-a3b8hyyr	3928	18	of	of	IN
cord-006860-a3b8hyyr	3928	19	major	major	JJ
cord-006860-a3b8hyyr	3928	20	heart	heart	NN
cord-006860-a3b8hyyr	3928	21	failure	failure	NN
cord-006860-a3b8hyyr	3928	22	and	and	CC
cord-006860-a3b8hyyr	3928	23	of	of	IN
cord-006860-a3b8hyyr	3928	24	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	3928	25	arrhythmias	arrhythmia	NNS
cord-006860-a3b8hyyr	3928	26	before	before	IN
cord-006860-a3b8hyyr	3928	27	begirming	begirming	NN
cord-006860-a3b8hyyr	3928	28	of	of	IN
cord-006860-a3b8hyyr	3928	29	the	the	DT
cord-006860-a3b8hyyr	3928	30	swim	swim	NN
cord-006860-a3b8hyyr	3928	31	training	training	NN
cord-006860-a3b8hyyr	3928	32	.	.	.
cord-006860-a3b8hyyr	3929	1	The	the	DT
cord-006860-a3b8hyyr	3929	2	principle	principle	NN
cord-006860-a3b8hyyr	3929	3	of	of	IN
cord-006860-a3b8hyyr	3929	4	the	the	DT
cord-006860-a3b8hyyr	3929	5	Fontan	Fontan	NNP
cord-006860-a3b8hyyr	3929	6	operation	operation	NN
cord-006860-a3b8hyyr	3929	7	consists	consist	VBZ
cord-006860-a3b8hyyr	3929	8	in	in	IN
cord-006860-a3b8hyyr	3929	9	anastomosing	anastomose	VBG
cord-006860-a3b8hyyr	3929	10	the	the	DT
cord-006860-a3b8hyyr	3929	11	right	right	JJ
cord-006860-a3b8hyyr	3929	12	atrium	atrium	NN
cord-006860-a3b8hyyr	3929	13	to	to	IN
cord-006860-a3b8hyyr	3929	14	the	the	DT
cord-006860-a3b8hyyr	3929	15	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	3929	16	arteria	arteria	NN
cord-006860-a3b8hyyr	3929	17	,	,	,
cord-006860-a3b8hyyr	3929	18	thus	thus	RB
cord-006860-a3b8hyyr	3929	19	bypassing	bypass	VBG
cord-006860-a3b8hyyr	3929	20	the	the	DT
cord-006860-a3b8hyyr	3929	21	right	right	JJ
cord-006860-a3b8hyyr	3929	22	ventricle	ventricle	NN
cord-006860-a3b8hyyr	3929	23	and	and	CC
cord-006860-a3b8hyyr	3929	24	using	use	VBG
cord-006860-a3b8hyyr	3929	25	the	the	DT
cord-006860-a3b8hyyr	3929	26	only	only	JJ
cord-006860-a3b8hyyr	3929	27	functional	functional	JJ
cord-006860-a3b8hyyr	3929	28	single	single	JJ
cord-006860-a3b8hyyr	3929	29	ventricle	ventricle	NN
cord-006860-a3b8hyyr	3929	30	as	as	IN
cord-006860-a3b8hyyr	3929	31	a	a	DT
cord-006860-a3b8hyyr	3929	32	pump	pump	NN
cord-006860-a3b8hyyr	3929	33	for	for	IN
cord-006860-a3b8hyyr	3929	34	the	the	DT
cord-006860-a3b8hyyr	3929	35	systemic	systemic	JJ
cord-006860-a3b8hyyr	3929	36	circulation	circulation	NN
cord-006860-a3b8hyyr	3929	37	.	.	.
cord-006860-a3b8hyyr	3930	1	There	there	EX
cord-006860-a3b8hyyr	3930	2	are	be	VBP
cord-006860-a3b8hyyr	3930	3	only	only	RB
cord-006860-a3b8hyyr	3930	4	few	few	JJ
cord-006860-a3b8hyyr	3930	5	data	datum	NNS
cord-006860-a3b8hyyr	3930	6	about	about	IN
cord-006860-a3b8hyyr	3930	7	the	the	DT
cord-006860-a3b8hyyr	3930	8	influence	influence	NN
cord-006860-a3b8hyyr	3930	9	of	of	IN
cord-006860-a3b8hyyr	3930	10	the	the	DT
cord-006860-a3b8hyyr	3930	11	changes	change	NNS
cord-006860-a3b8hyyr	3930	12	in	in	IN
cord-006860-a3b8hyyr	3930	13	hemodynamics	hemodynamic	NNS
cord-006860-a3b8hyyr	3930	14	on	on	IN
cord-006860-a3b8hyyr	3930	15	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3930	16	and	and	CC
cord-006860-a3b8hyyr	3930	17	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	3930	18	.	.	.
cord-006860-a3b8hyyr	3931	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3931	2	investigated	investigate	VBD
cord-006860-a3b8hyyr	3931	3	the	the	DT
cord-006860-a3b8hyyr	3931	4	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3931	5	system	system	NN
cord-006860-a3b8hyyr	3931	6	in	in	IN
cord-006860-a3b8hyyr	3931	7	20	20	CD
cord-006860-a3b8hyyr	3931	8	children	child	NNS
cord-006860-a3b8hyyr	3931	9	and	and	CC
cord-006860-a3b8hyyr	3931	10	young	young	JJ
cord-006860-a3b8hyyr	3931	11	adults	adult	NNS
cord-006860-a3b8hyyr	3931	12	aged	age	VBN
cord-006860-a3b8hyyr	3931	13	4	4	CD
cord-006860-a3b8hyyr	3931	14	to	to	TO
cord-006860-a3b8hyyr	3931	15	21	21	CD
cord-006860-a3b8hyyr	3931	16	years	year	NNS
cord-006860-a3b8hyyr	3931	17	in	in	IN
cord-006860-a3b8hyyr	3931	18	a	a	DT
cord-006860-a3b8hyyr	3931	19	general	general	JJ
cord-006860-a3b8hyyr	3931	20	examination	examination	NN
cord-006860-a3b8hyyr	3931	21	4	4	CD
cord-006860-a3b8hyyr	3931	22	to	to	TO
cord-006860-a3b8hyyr	3931	23	61	61	CD
cord-006860-a3b8hyyr	3931	24	months	month	NNS
cord-006860-a3b8hyyr	3931	25	after	after	IN
cord-006860-a3b8hyyr	3931	26	Fontan	Fontan	NNP
cord-006860-a3b8hyyr	3931	27	procedure	procedure	NN
cord-006860-a3b8hyyr	3931	28	.	.	.
cord-006860-a3b8hyyr	3932	1	Besides	besides	IN
cord-006860-a3b8hyyr	3932	2	other	other	JJ
cord-006860-a3b8hyyr	3932	3	abnormalities	abnormality	NNS
cord-006860-a3b8hyyr	3932	4	of	of	IN
cord-006860-a3b8hyyr	3932	5	the	the	DT
cord-006860-a3b8hyyr	3932	6	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3932	7	system	system	NN
cord-006860-a3b8hyyr	3932	8	,	,	,
cord-006860-a3b8hyyr	3932	9	there	there	EX
cord-006860-a3b8hyyr	3932	10	were	be	VBD
cord-006860-a3b8hyyr	3932	11	significantly	significantly	RB
cord-006860-a3b8hyyr	3932	12	increased	increase	VBN
cord-006860-a3b8hyyr	3932	13	values	value	NNS
cord-006860-a3b8hyyr	3932	14	for	for	IN
cord-006860-a3b8hyyr	3932	15	the	the	DT
cord-006860-a3b8hyyr	3932	16	thrombin	thrombin	NN
cord-006860-a3b8hyyr	3932	17	-	-	HYPH
cord-006860-a3b8hyyr	3932	18	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	3932	19	-	-	HYPH
cord-006860-a3b8hyyr	3932	20	III	III	NNP
cord-006860-a3b8hyyr	3932	21	-	-	HYPH
cord-006860-a3b8hyyr	3932	22	complex	complex	JJ
cord-006860-a3b8hyyr	3932	23	(	(	-LRB-
cord-006860-a3b8hyyr	3932	24	TAT	tat	NN
cord-006860-a3b8hyyr	3932	25	)	)	-RRB-
cord-006860-a3b8hyyr	3932	26	in	in	IN
cord-006860-a3b8hyyr	3932	27	12	12	CD
cord-006860-a3b8hyyr	3932	28	Patients	patient	NNS
cord-006860-a3b8hyyr	3932	29	(	(	-LRB-
cord-006860-a3b8hyyr	3932	30	60	60	CD
cord-006860-a3b8hyyr	3932	31	%	%	NN
cord-006860-a3b8hyyr	3932	32	)	)	-RRB-
cord-006860-a3b8hyyr	3932	33	.	.	.
cord-006860-a3b8hyyr	3933	1	As	as	IN
cord-006860-a3b8hyyr	3933	2	a	a	DT
cord-006860-a3b8hyyr	3933	3	marker	marker	NN
cord-006860-a3b8hyyr	3933	4	for	for	IN
cord-006860-a3b8hyyr	3933	5	an	an	DT
cord-006860-a3b8hyyr	3933	6	activation	activation	NN
cord-006860-a3b8hyyr	3933	7	of	of	IN
cord-006860-a3b8hyyr	3933	8	the	the	DT
cord-006860-a3b8hyyr	3933	9	fibdnolytic	fibdnolytic	JJ
cord-006860-a3b8hyyr	3933	10	system	system	NN
cord-006860-a3b8hyyr	3933	11	we	-PRON-	PRP
cord-006860-a3b8hyyr	3933	12	found	find	VBD
cord-006860-a3b8hyyr	3933	13	elevated	elevated	JJ
cord-006860-a3b8hyyr	3933	14	plasmin	plasmin	NN
cord-006860-a3b8hyyr	3933	15	-	-	HYPH
cord-006860-a3b8hyyr	3933	16	alpha2-antiplasmin-(PAP-	alpha2-antiplasmin-(PAP-	NNP
cord-006860-a3b8hyyr	3933	17	)	)	-RRB-
cord-006860-a3b8hyyr	3933	18	levels	level	NNS
cord-006860-a3b8hyyr	3933	19	in	in	IN
cord-006860-a3b8hyyr	3933	20	14	14	CD
cord-006860-a3b8hyyr	3933	21	patients	patient	NNS
cord-006860-a3b8hyyr	3933	22	(	(	-LRB-
cord-006860-a3b8hyyr	3933	23	70	70	CD
cord-006860-a3b8hyyr	3933	24	%	%	NN
cord-006860-a3b8hyyr	3933	25	)	)	-RRB-
cord-006860-a3b8hyyr	3933	26	.	.	.
cord-006860-a3b8hyyr	3934	1	Less	less	RBR
cord-006860-a3b8hyyr	3934	2	frequently	frequently	RB
cord-006860-a3b8hyyr	3934	3	,	,	,
cord-006860-a3b8hyyr	3934	4	the	the	DT
cord-006860-a3b8hyyr	3934	5	concentrations	concentration	NNS
cord-006860-a3b8hyyr	3934	6	for	for	IN
cord-006860-a3b8hyyr	3934	7	the	the	DT
cord-006860-a3b8hyyr	3934	8	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	3934	9	-	-	HYPH
cord-006860-a3b8hyyr	3934	10	fragments	fragment	NNS
cord-006860-a3b8hyyr	3934	11	1	1	CD
cord-006860-a3b8hyyr	3934	12	and	and	CC
cord-006860-a3b8hyyr	3934	13	2	2	CD
cord-006860-a3b8hyyr	3934	14	(	(	-LRB-
cord-006860-a3b8hyyr	3934	15	F1	f1	NN
cord-006860-a3b8hyyr	3934	16	and	and	CC
cord-006860-a3b8hyyr	3934	17	2	2	LS
cord-006860-a3b8hyyr	3934	18	)	)	-RRB-
cord-006860-a3b8hyyr	3934	19	(	(	-LRB-
cord-006860-a3b8hyyr	3934	20	7	7	CD
cord-006860-a3b8hyyr	3934	21	patients	patient	NNS
cord-006860-a3b8hyyr	3934	22	,	,	,
cord-006860-a3b8hyyr	3934	23	35	35	CD
cord-006860-a3b8hyyr	3934	24	%	%	NN
cord-006860-a3b8hyyr	3934	25	)	)	-RRB-
cord-006860-a3b8hyyr	3934	26	or	or	CC
cord-006860-a3b8hyyr	3934	27	the	the	DT
cord-006860-a3b8hyyr	3934	28	d	d	NN
cord-006860-a3b8hyyr	3934	29	-	-	HYPH
cord-006860-a3b8hyyr	3934	30	dimer	dimer	JJ
cord-006860-a3b8hyyr	3934	31	(	(	-LRB-
cord-006860-a3b8hyyr	3934	32	2	2	CD
cord-006860-a3b8hyyr	3934	33	patients	patient	NNS
cord-006860-a3b8hyyr	3934	34	,	,	,
cord-006860-a3b8hyyr	3934	35	10	10	CD
cord-006860-a3b8hyyr	3934	36	%	%	NN
cord-006860-a3b8hyyr	3934	37	)	)	-RRB-
cord-006860-a3b8hyyr	3934	38	were	be	VBD
cord-006860-a3b8hyyr	3934	39	increased	increase	VBN
cord-006860-a3b8hyyr	3934	40	.	.	.
cord-006860-a3b8hyyr	3935	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3935	2	did	do	VBD
cord-006860-a3b8hyyr	3935	3	n't	not	RB
cord-006860-a3b8hyyr	3935	4	find	find	VB
cord-006860-a3b8hyyr	3935	5	significant	significant	JJ
cord-006860-a3b8hyyr	3935	6	differences	difference	NNS
cord-006860-a3b8hyyr	3935	7	in	in	IN
cord-006860-a3b8hyyr	3935	8	a	a	DT
cord-006860-a3b8hyyr	3935	9	clot	clot	NN
cord-006860-a3b8hyyr	3935	10	-	-	HYPH
cord-006860-a3b8hyyr	3935	11	lysis	lysis	NN
cord-006860-a3b8hyyr	3935	12	-	-	HYPH
cord-006860-a3b8hyyr	3935	13	assay	assay	NN
cord-006860-a3b8hyyr	3935	14	between	between	IN
cord-006860-a3b8hyyr	3935	15	Fontanoperated	Fontanoperated	NNP
cord-006860-a3b8hyyr	3935	16	patients	patient	NNS
cord-006860-a3b8hyyr	3935	17	and	and	CC
cord-006860-a3b8hyyr	3935	18	an	an	DT
cord-006860-a3b8hyyr	3935	19	age	age	NN
cord-006860-a3b8hyyr	3935	20	-	-	HYPH
cord-006860-a3b8hyyr	3935	21	matched	match	VBN
cord-006860-a3b8hyyr	3935	22	control	control	NN
cord-006860-a3b8hyyr	3935	23	group	group	NN
cord-006860-a3b8hyyr	3935	24	.	.	.
cord-006860-a3b8hyyr	3936	1	There	there	EX
cord-006860-a3b8hyyr	3936	2	was	be	VBD
cord-006860-a3b8hyyr	3936	3	no	no	DT
cord-006860-a3b8hyyr	3936	4	significant	significant	JJ
cord-006860-a3b8hyyr	3936	5	correlation	correlation	NN
cord-006860-a3b8hyyr	3936	6	between	between	IN
cord-006860-a3b8hyyr	3936	7	activation	activation	NN
cord-006860-a3b8hyyr	3936	8	of	of	IN
cord-006860-a3b8hyyr	3936	9	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3936	10	and	and	CC
cord-006860-a3b8hyyr	3936	11	clinical	clinical	JJ
cord-006860-a3b8hyyr	3936	12	situation	situation	NN
cord-006860-a3b8hyyr	3936	13	or	or	CC
cord-006860-a3b8hyyr	3936	14	diameter	diameter	NN
cord-006860-a3b8hyyr	3936	15	of	of	IN
cord-006860-a3b8hyyr	3936	16	the	the	DT
cord-006860-a3b8hyyr	3936	17	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	3936	18	arteria	arteria	NN
cord-006860-a3b8hyyr	3936	19	.	.	.
cord-006860-a3b8hyyr	3937	1	Whether	whether	IN
cord-006860-a3b8hyyr	3937	2	the	the	DT
cord-006860-a3b8hyyr	3937	3	present	present	JJ
cord-006860-a3b8hyyr	3937	4	data	data	NN
cord-006860-a3b8hyyr	3937	5	can	can	MD
cord-006860-a3b8hyyr	3937	6	help	help	VB
cord-006860-a3b8hyyr	3937	7	to	to	TO
cord-006860-a3b8hyyr	3937	8	estimate	estimate	VB
cord-006860-a3b8hyyr	3937	9	the	the	DT
cord-006860-a3b8hyyr	3937	10	risk	risk	NN
cord-006860-a3b8hyyr	3937	11	for	for	IN
cord-006860-a3b8hyyr	3937	12	a	a	DT
cord-006860-a3b8hyyr	3937	13	thrombo	thrombo	JJ
cord-006860-a3b8hyyr	3937	14	-	-	HYPH
cord-006860-a3b8hyyr	3937	15	embolic	embolic	NN
cord-006860-a3b8hyyr	3937	16	complication	complication	NN
cord-006860-a3b8hyyr	3937	17	following	follow	VBG
cord-006860-a3b8hyyr	3937	18	Fontan	Fontan	NNP
cord-006860-a3b8hyyr	3937	19	procedure	procedure	NN
cord-006860-a3b8hyyr	3937	20	,	,	,
cord-006860-a3b8hyyr	3937	21	still	still	RB
cord-006860-a3b8hyyr	3937	22	has	have	VBZ
cord-006860-a3b8hyyr	3937	23	to	to	TO
cord-006860-a3b8hyyr	3937	24	be	be	VB
cord-006860-a3b8hyyr	3937	25	investigated	investigate	VBN
cord-006860-a3b8hyyr	3937	26	.	.	.
cord-006860-a3b8hyyr	3938	1	The	the	DT
cord-006860-a3b8hyyr	3938	2	results	result	NNS
cord-006860-a3b8hyyr	3938	3	of	of	IN
cord-006860-a3b8hyyr	3938	4	the	the	DT
cord-006860-a3b8hyyr	3938	5	clot	clot	NN
cord-006860-a3b8hyyr	3938	6	-	-	HYPH
cord-006860-a3b8hyyr	3938	7	lysis	lysis	NN
cord-006860-a3b8hyyr	3938	8	-	-	HYPH
cord-006860-a3b8hyyr	3938	9	assay	assay	NN
cord-006860-a3b8hyyr	3938	10	suggest	suggest	VBP
cord-006860-a3b8hyyr	3938	11	,	,	,
cord-006860-a3b8hyyr	3938	12	that	that	IN
cord-006860-a3b8hyyr	3938	13	for	for	IN
cord-006860-a3b8hyyr	3938	14	lysis	lysis	NN
cord-006860-a3b8hyyr	3938	15	of	of	IN
cord-006860-a3b8hyyr	3938	16	thrombi	thrombi	NNP
cord-006860-a3b8hyyr	3938	17	the	the	DT
cord-006860-a3b8hyyr	3938	18	same	same	JJ
cord-006860-a3b8hyyr	3938	19	dose	dose	NN
cord-006860-a3b8hyyr	3938	20	of	of	IN
cord-006860-a3b8hyyr	3938	21	rt	rt	NNP
cord-006860-a3b8hyyr	3938	22	-	-	HYPH
cord-006860-a3b8hyyr	3938	23	PA	PA	NNP
cord-006860-a3b8hyyr	3938	24	should	should	MD
cord-006860-a3b8hyyr	3938	25	be	be	VB
cord-006860-a3b8hyyr	3938	26	used	use	VBN
cord-006860-a3b8hyyr	3938	27	as	as	IN
cord-006860-a3b8hyyr	3938	28	for	for	IN
cord-006860-a3b8hyyr	3938	29	other	other	JJ
cord-006860-a3b8hyyr	3938	30	patients	patient	NNS
cord-006860-a3b8hyyr	3938	31	.	.	.
cord-006860-a3b8hyyr	3939	1	A	a	DT
cord-006860-a3b8hyyr	3939	2	2nd	2nd	JJ
cord-006860-a3b8hyyr	3939	3	GENERATION	generation	NN
cord-006860-a3b8hyyr	3939	4	FUNCTIONAL	functional	JJ
cord-006860-a3b8hyyr	3939	5	PROTEIN	protein	NN
cord-006860-a3b8hyyr	3939	6	S	S	NNP
cord-006860-a3b8hyyr	3939	7	ASSAY	assay	NN
cord-006860-a3b8hyyr	3939	8	P.	P.	NNP
cord-006860-a3b8hyyr	3939	9	van	van	NNP
cord-006860-a3b8hyyr	3939	10	Dreden	Dreden	NNP
cord-006860-a3b8hyyr	3939	11	*	*	NFP
cord-006860-a3b8hyyr	3939	12	and	and	CC
cord-006860-a3b8hyyr	3939	13	E.	E.	NNP
cord-006860-a3b8hyyr	3939	14	Adema	Adema	NNP
cord-006860-a3b8hyyr	3940	1	*	*	NFP
cord-006860-a3b8hyyr	3940	2	*	*	NFP
cord-006860-a3b8hyyr	3940	3	*	*	NFP
cord-006860-a3b8hyyr	3940	4	Serbio	Serbio	NNP
cord-006860-a3b8hyyr	3940	5	,	,	,
cord-006860-a3b8hyyr	3940	6	Gennevilliers	Gennevilliers	NNP
cord-006860-a3b8hyyr	3940	7	France	France	NNP
cord-006860-a3b8hyyr	3940	8	,	,	,
cord-006860-a3b8hyyr	3941	1	*	*	NFP
cord-006860-a3b8hyyr	3941	2	*	*	NFP
cord-006860-a3b8hyyr	3941	3	Boehringer	Boehringer	NNP
cord-006860-a3b8hyyr	3941	4	Mannheim	Mannheim	NNP
cord-006860-a3b8hyyr	3941	5	,	,	,
cord-006860-a3b8hyyr	3941	6	Tutzing	Tutzing	NNP
cord-006860-a3b8hyyr	3941	7	Germany	Germany	NNP
cord-006860-a3b8hyyr	3942	1	A	a	DT
cord-006860-a3b8hyyr	3942	2	second	second	JJ
cord-006860-a3b8hyyr	3942	3	generation	generation	NN
cord-006860-a3b8hyyr	3942	4	protein	protein	NN
cord-006860-a3b8hyyr	3942	5	S	S	NNP
cord-006860-a3b8hyyr	3942	6	test	test	NN
cord-006860-a3b8hyyr	3942	7	was	be	VBD
cord-006860-a3b8hyyr	3942	8	developed	develop	VBN
cord-006860-a3b8hyyr	3942	9	with	with	IN
cord-006860-a3b8hyyr	3942	10	improved	improved	JJ
cord-006860-a3b8hyyr	3942	11	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	3942	12	to	to	IN
cord-006860-a3b8hyyr	3942	13	protein	protein	NN
cord-006860-a3b8hyyr	3942	14	S	S	NNP
cord-006860-a3b8hyyr	3942	15	and	and	CC
cord-006860-a3b8hyyr	3942	16	better	well	JJR
cord-006860-a3b8hyyr	3942	17	reagent	reagent	JJ
cord-006860-a3b8hyyr	3942	18	stability	stability	NN
cord-006860-a3b8hyyr	3942	19	.	.	.
cord-006860-a3b8hyyr	3943	1	The	the	DT
cord-006860-a3b8hyyr	3943	2	test	test	NN
cord-006860-a3b8hyyr	3943	3	result	result	NN
cord-006860-a3b8hyyr	3943	4	was	be	VBD
cord-006860-a3b8hyyr	3943	5	found	find	VBN
cord-006860-a3b8hyyr	3943	6	to	to	TO
cord-006860-a3b8hyyr	3943	7	be	be	VB
cord-006860-a3b8hyyr	3943	8	unaffected	unaffected	JJ
cord-006860-a3b8hyyr	3943	9	by	by	IN
cord-006860-a3b8hyyr	3943	10	APC	APC	NNP
cord-006860-a3b8hyyr	3943	11	-	-	HYPH
cord-006860-a3b8hyyr	3943	12	Resistence	Resistence	NNP
cord-006860-a3b8hyyr	3943	13	(	(	-LRB-
cord-006860-a3b8hyyr	3943	14	10	10	CD
cord-006860-a3b8hyyr	3943	15	patients	patient	NNS
cord-006860-a3b8hyyr	3943	16	,	,	,
cord-006860-a3b8hyyr	3943	17	heterozygote	heterozygote	VB
cord-006860-a3b8hyyr	3943	18	for	for	IN
cord-006860-a3b8hyyr	3943	19	the	the	DT
cord-006860-a3b8hyyr	3943	20	mutation	mutation	NN
cord-006860-a3b8hyyr	3943	21	with	with	IN
cord-006860-a3b8hyyr	3943	22	a	a	DT
cord-006860-a3b8hyyr	3943	23	aPTI	apti	NN
cord-006860-a3b8hyyr	3943	24	'	'	''
cord-006860-a3b8hyyr	3944	1	+	+	CC
cord-006860-a3b8hyyr	3944	2	aPC	aPC	NNP
cord-006860-a3b8hyyr	3944	3	ratio	ratio	NN
cord-006860-a3b8hyyr	3944	4	between	between	IN
cord-006860-a3b8hyyr	3944	5	1.4	1.4	CD
cord-006860-a3b8hyyr	3944	6	and	and	CC
cord-006860-a3b8hyyr	3944	7	1.9	1.9	CD
cord-006860-a3b8hyyr	3944	8	)	)	-RRB-
cord-006860-a3b8hyyr	3944	9	,	,	,
cord-006860-a3b8hyyr	3944	10	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	3944	11	up	up	IN
cord-006860-a3b8hyyr	3944	12	to	to	IN
cord-006860-a3b8hyyr	3944	13	2	2	CD
cord-006860-a3b8hyyr	3944	14	IU	IU	NNP
cord-006860-a3b8hyyr	3944	15	/	/	SYM
cord-006860-a3b8hyyr	3944	16	ml	ml	NN
cord-006860-a3b8hyyr	3944	17	and	and	CC
cord-006860-a3b8hyyr	3944	18	F	F	NNP
cord-006860-a3b8hyyr	3944	19	VIII	VIII	NNP
cord-006860-a3b8hyyr	3944	20	activity	activity	NN
cord-006860-a3b8hyyr	3944	21	between	between	IN
cord-006860-a3b8hyyr	3944	22	1	1	CD
cord-006860-a3b8hyyr	3944	23	and	and	CC
cord-006860-a3b8hyyr	3944	24	250	250	CD
cord-006860-a3b8hyyr	3944	25	%	%	NN
cord-006860-a3b8hyyr	3944	26	.	.	.
cord-006860-a3b8hyyr	3945	1	In	in	IN
cord-006860-a3b8hyyr	3945	2	the	the	DT
cord-006860-a3b8hyyr	3945	3	test	test	NN
cord-006860-a3b8hyyr	3945	4	,	,	,
cord-006860-a3b8hyyr	3945	5	diluted	dilute	VBN
cord-006860-a3b8hyyr	3945	6	sample	sample	NN
cord-006860-a3b8hyyr	3945	7	is	be	VBZ
cord-006860-a3b8hyyr	3945	8	mixed	mix	VBN
cord-006860-a3b8hyyr	3945	9	with	with	IN
cord-006860-a3b8hyyr	3945	10	protein	protein	NN
cord-006860-a3b8hyyr	3945	11	S	S	NNP
cord-006860-a3b8hyyr	3945	12	deficient	deficient	JJ
cord-006860-a3b8hyyr	3945	13	plasma	plasma	NN
cord-006860-a3b8hyyr	3945	14	,	,	,
cord-006860-a3b8hyyr	3945	15	activated	activate	VBN
cord-006860-a3b8hyyr	3945	16	factor	factor	NN
cord-006860-a3b8hyyr	3945	17	V	v	NN
cord-006860-a3b8hyyr	3945	18	,	,	,
cord-006860-a3b8hyyr	3945	19	activated	activate	VBD
cord-006860-a3b8hyyr	3945	20	protein	protein	NN
cord-006860-a3b8hyyr	3945	21	C	c	NN
cord-006860-a3b8hyyr	3945	22	,	,	,
cord-006860-a3b8hyyr	3945	23	phospholipids	phospholipid	NNS
cord-006860-a3b8hyyr	3945	24	and	and	CC
cord-006860-a3b8hyyr	3945	25	an	an	DT
cord-006860-a3b8hyyr	3945	26	intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	3945	27	pathway	pathway	NN
cord-006860-a3b8hyyr	3945	28	activator	activator	NN
cord-006860-a3b8hyyr	3945	29	.	.	.
cord-006860-a3b8hyyr	3946	1	This	this	DT
cord-006860-a3b8hyyr	3946	2	mixture	mixture	NN
cord-006860-a3b8hyyr	3946	3	is	be	VBZ
cord-006860-a3b8hyyr	3946	4	incubated	incubate	VBN
cord-006860-a3b8hyyr	3946	5	for	for	IN
cord-006860-a3b8hyyr	3946	6	3	3	CD
cord-006860-a3b8hyyr	3946	7	minutes	minute	NNS
cord-006860-a3b8hyyr	3946	8	.	.	.
cord-006860-a3b8hyyr	3947	1	During	during	IN
cord-006860-a3b8hyyr	3947	2	this	this	DT
cord-006860-a3b8hyyr	3947	3	time	time	NN
cord-006860-a3b8hyyr	3947	4	,	,	,
cord-006860-a3b8hyyr	3947	5	the	the	DT
cord-006860-a3b8hyyr	3947	6	activated	activate	VBN
cord-006860-a3b8hyyr	3947	7	protein	protein	NN
cord-006860-a3b8hyyr	3947	8	C	C	NNP
cord-006860-a3b8hyyr	3947	9	inactivates	inactivate	VBZ
cord-006860-a3b8hyyr	3947	10	part	part	NN
cord-006860-a3b8hyyr	3947	11	of	of	IN
cord-006860-a3b8hyyr	3948	1	the	the	DT
cord-006860-a3b8hyyr	3948	2	F	F	NNP
cord-006860-a3b8hyyr	3948	3	Va.	Virginia	NNP
cord-006860-a3b8hyyr	3948	4	The	the	DT
cord-006860-a3b8hyyr	3948	5	extend	extend	NN
cord-006860-a3b8hyyr	3948	6	of	of	IN
cord-006860-a3b8hyyr	3948	7	F	F	NNP
cord-006860-a3b8hyyr	3948	8	Va	Va	NNP
cord-006860-a3b8hyyr	3948	9	inactivation	inactivation	NN
cord-006860-a3b8hyyr	3948	10	depends	depend	VBZ
cord-006860-a3b8hyyr	3948	11	on	on	IN
cord-006860-a3b8hyyr	3948	12	the	the	DT
cord-006860-a3b8hyyr	3948	13	protein	protein	NN
cord-006860-a3b8hyyr	3948	14	S	S	NNP
cord-006860-a3b8hyyr	3948	15	concentration	concentration	NN
cord-006860-a3b8hyyr	3948	16	.	.	.
cord-006860-a3b8hyyr	3949	1	After	after	IN
cord-006860-a3b8hyyr	3949	2	3	3	CD
cord-006860-a3b8hyyr	3949	3	minutes	minute	NNS
cord-006860-a3b8hyyr	3949	4	CaCI2	CaCI2	NNP
cord-006860-a3b8hyyr	3949	5	is	be	VBZ
cord-006860-a3b8hyyr	3949	6	added	add	VBN
cord-006860-a3b8hyyr	3949	7	and	and	CC
cord-006860-a3b8hyyr	3949	8	the	the	DT
cord-006860-a3b8hyyr	3949	9	time	time	NN
cord-006860-a3b8hyyr	3949	10	untill	untill	NN
cord-006860-a3b8hyyr	3949	11	clot	clot	NN
cord-006860-a3b8hyyr	3949	12	formation	formation	NN
cord-006860-a3b8hyyr	3949	13	is	be	VBZ
cord-006860-a3b8hyyr	3949	14	measured	measure	VBN
cord-006860-a3b8hyyr	3949	15	.	.	.
cord-006860-a3b8hyyr	3950	1	The	the	DT
cord-006860-a3b8hyyr	3950	2	clotting	clotting	NN
cord-006860-a3b8hyyr	3950	3	time	time	NN
cord-006860-a3b8hyyr	3950	4	is	be	VBZ
cord-006860-a3b8hyyr	3950	5	a	a	DT
cord-006860-a3b8hyyr	3950	6	linear	linear	JJ
cord-006860-a3b8hyyr	3950	7	function	function	NN
cord-006860-a3b8hyyr	3950	8	of	of	IN
cord-006860-a3b8hyyr	3950	9	the	the	DT
cord-006860-a3b8hyyr	3950	10	protein	protein	NN
cord-006860-a3b8hyyr	3950	11	S	S	NNP
cord-006860-a3b8hyyr	3950	12	concentration	concentration	NN
cord-006860-a3b8hyyr	3950	13	between	between	IN
cord-006860-a3b8hyyr	3950	14	10	10	CD
cord-006860-a3b8hyyr	3950	15	and	and	CC
cord-006860-a3b8hyyr	3950	16	140	140	CD
cord-006860-a3b8hyyr	3950	17	%	%	NN
cord-006860-a3b8hyyr	3950	18	protein	protein	NN
cord-006860-a3b8hyyr	3950	19	S.	S.	NNP
cord-006860-a3b8hyyr	3951	1	For	for	IN
cord-006860-a3b8hyyr	3951	2	the	the	DT
cord-006860-a3b8hyyr	3951	3	three	three	CD
cord-006860-a3b8hyyr	3951	4	preproduction	preproduction	NN
cord-006860-a3b8hyyr	3951	5	lots	lot	VBZ
cord-006860-a3b8hyyr	3951	6	the	the	DT
cord-006860-a3b8hyyr	3951	7	difference	difference	NN
cord-006860-a3b8hyyr	3951	8	in	in	IN
cord-006860-a3b8hyyr	3951	9	dotting	dot	VBG
cord-006860-a3b8hyyr	3951	10	time	time	NN
cord-006860-a3b8hyyr	3951	11	between	between	IN
cord-006860-a3b8hyyr	3951	12	10	10	CD
cord-006860-a3b8hyyr	3951	13	and	and	CC
cord-006860-a3b8hyyr	3951	14	100	100	CD
cord-006860-a3b8hyyr	3951	15	%	%	NN
cord-006860-a3b8hyyr	3951	16	protein	protein	NN
cord-006860-a3b8hyyr	3951	17	S	S	NNP
cord-006860-a3b8hyyr	3951	18	was	be	VBD
cord-006860-a3b8hyyr	3951	19	43	43	CD
cord-006860-a3b8hyyr	3951	20	-	-	SYM
cord-006860-a3b8hyyr	3951	21	54	54	CD
cord-006860-a3b8hyyr	3951	22	seconds	second	NNS
cord-006860-a3b8hyyr	3951	23	.	.	.
cord-006860-a3b8hyyr	3952	1	This	this	DT
cord-006860-a3b8hyyr	3952	2	compares	compare	VBZ
cord-006860-a3b8hyyr	3952	3	to	to	IN
cord-006860-a3b8hyyr	3952	4	30	30	CD
cord-006860-a3b8hyyr	3952	5	-	-	SYM
cord-006860-a3b8hyyr	3952	6	40	40	CD
cord-006860-a3b8hyyr	3952	7	seconds	second	NNS
cord-006860-a3b8hyyr	3952	8	typically	typically	RB
cord-006860-a3b8hyyr	3952	9	obtained	obtain	VBN
cord-006860-a3b8hyyr	3952	10	with	with	IN
cord-006860-a3b8hyyr	3952	11	the	the	DT
cord-006860-a3b8hyyr	3952	12	old	old	JJ
cord-006860-a3b8hyyr	3952	13	test	test	NN
cord-006860-a3b8hyyr	3952	14	.	.	.
cord-006860-a3b8hyyr	3953	1	Within	within	IN
cord-006860-a3b8hyyr	3953	2	run	run	NN
cord-006860-a3b8hyyr	3953	3	precision	precision	NN
cord-006860-a3b8hyyr	3953	4	(	(	-LRB-
cord-006860-a3b8hyyr	3953	5	n=	n=	NNP
cord-006860-a3b8hyyr	3953	6	I0	i0	NN
cord-006860-a3b8hyyr	3953	7	on	on	IN
cord-006860-a3b8hyyr	3953	8	STA	STA	NNP
cord-006860-a3b8hyyr	3953	9	)	)	-RRB-
cord-006860-a3b8hyyr	3953	10	is	be	VBZ
cord-006860-a3b8hyyr	3953	11	cv=	cv=	NNP
cord-006860-a3b8hyyr	3953	12	2	2	CD
cord-006860-a3b8hyyr	3953	13	-7	-7	CD
cord-006860-a3b8hyyr	3953	14	%	%	NN
cord-006860-a3b8hyyr	3953	15	on	on	IN
cord-006860-a3b8hyyr	3953	16	the	the	DT
cord-006860-a3b8hyyr	3953	17	basis	basis	NN
cord-006860-a3b8hyyr	3953	18	of	of	IN
cord-006860-a3b8hyyr	3953	19	Protein	Protein	NNP
cord-006860-a3b8hyyr	3953	20	S.	S.	NNP
cord-006860-a3b8hyyr	3953	21	Day	Day	NNP
cord-006860-a3b8hyyr	3953	22	to	to	IN
cord-006860-a3b8hyyr	3953	23	day	day	NN
cord-006860-a3b8hyyr	3953	24	precision	precision	NN
cord-006860-a3b8hyyr	3953	25	(	(	-LRB-
cord-006860-a3b8hyyr	3953	26	n=10	n=10	NNP
cord-006860-a3b8hyyr	3953	27	on	on	IN
cord-006860-a3b8hyyr	3953	28	STA	STA	NNP
cord-006860-a3b8hyyr	3953	29	)	)	-RRB-
cord-006860-a3b8hyyr	3953	30	was	be	VBD
cord-006860-a3b8hyyr	3953	31	found	find	VBN
cord-006860-a3b8hyyr	3953	32	to	to	TO
cord-006860-a3b8hyyr	3953	33	be	be	VB
cord-006860-a3b8hyyr	3953	34	cv=	cv=	NNP
cord-006860-a3b8hyyr	3953	35	4	4	CD
cord-006860-a3b8hyyr	3953	36	-11	-11	CD
cord-006860-a3b8hyyr	3953	37	%	%	NN
cord-006860-a3b8hyyr	3953	38	,	,	,
cord-006860-a3b8hyyr	3953	39	again	again	RB
cord-006860-a3b8hyyr	3953	40	calculated	calculate	VBN
cord-006860-a3b8hyyr	3953	41	on	on	IN
cord-006860-a3b8hyyr	3953	42	the	the	DT
cord-006860-a3b8hyyr	3953	43	basis	basis	NN
cord-006860-a3b8hyyr	3953	44	of	of	IN
cord-006860-a3b8hyyr	3953	45	protein	protein	NN
cord-006860-a3b8hyyr	3953	46	S	S	NNP
cord-006860-a3b8hyyr	3953	47	concentration	concentration	NN
cord-006860-a3b8hyyr	3953	48	.	.	.
cord-006860-a3b8hyyr	3954	1	The	the	DT
cord-006860-a3b8hyyr	3954	2	cv	cv	NN
cord-006860-a3b8hyyr	3954	3	of	of	IN
cord-006860-a3b8hyyr	3954	4	11	11	CD
cord-006860-a3b8hyyr	3954	5	%	%	NN
cord-006860-a3b8hyyr	3954	6	was	be	VBD
cord-006860-a3b8hyyr	3954	7	obtained	obtain	VBN
cord-006860-a3b8hyyr	3954	8	for	for	IN
cord-006860-a3b8hyyr	3954	9	an	an	DT
cord-006860-a3b8hyyr	3954	10	AVK	AVK	NNP
cord-006860-a3b8hyyr	3954	11	plasma	plasma	NN
cord-006860-a3b8hyyr	3954	12	with	with	IN
cord-006860-a3b8hyyr	3954	13	13	13	CD
cord-006860-a3b8hyyr	3954	14	%	%	NN
cord-006860-a3b8hyyr	3954	15	protein	protein	NN
cord-006860-a3b8hyyr	3954	16	S	s	NN
cord-006860-a3b8hyyr	3954	17	;	;	:
cord-006860-a3b8hyyr	3954	18	it	-PRON-	PRP
cord-006860-a3b8hyyr	3954	19	corresponds	correspond	VBZ
cord-006860-a3b8hyyr	3954	20	to	to	IN
cord-006860-a3b8hyyr	3954	21	a	a	DT
cord-006860-a3b8hyyr	3954	22	standard	standard	JJ
cord-006860-a3b8hyyr	3954	23	deviation	deviation	NN
cord-006860-a3b8hyyr	3954	24	of	of	IN
cord-006860-a3b8hyyr	3954	25	only	only	RB
cord-006860-a3b8hyyr	3954	26	1.5	1.5	CD
cord-006860-a3b8hyyr	3954	27	%	%	NN
cord-006860-a3b8hyyr	3954	28	in	in	IN
cord-006860-a3b8hyyr	3954	29	protein	protein	NN
cord-006860-a3b8hyyr	3954	30	S.	S.	NNP
cord-006860-a3b8hyyr	3955	1	The	the	DT
cord-006860-a3b8hyyr	3955	2	insensitivity	insensitivity	NN
cord-006860-a3b8hyyr	3955	3	to	to	IN
cord-006860-a3b8hyyr	3955	4	interferences	interference	NNS
cord-006860-a3b8hyyr	3955	5	,	,	,
cord-006860-a3b8hyyr	3955	6	in	in	IN
cord-006860-a3b8hyyr	3955	7	particular	particular	JJ
cord-006860-a3b8hyyr	3955	8	APC	APC	NNP
cord-006860-a3b8hyyr	3955	9	-	-	HYPH
cord-006860-a3b8hyyr	3955	10	Resistence	Resistence	NNP
cord-006860-a3b8hyyr	3955	11	and	and	CC
cord-006860-a3b8hyyr	3955	12	better	well	JJR
cord-006860-a3b8hyyr	3955	13	precision	precision	NN
cord-006860-a3b8hyyr	3955	14	and	and	CC
cord-006860-a3b8hyyr	3955	15	stability	stability	NN
cord-006860-a3b8hyyr	3955	16	are	be	VBP
cord-006860-a3b8hyyr	3955	17	expected	expect	VBN
cord-006860-a3b8hyyr	3955	18	to	to	TO
cord-006860-a3b8hyyr	3955	19	improve	improve	VB
cord-006860-a3b8hyyr	3955	20	the	the	DT
cord-006860-a3b8hyyr	3955	21	quality	quality	NN
cord-006860-a3b8hyyr	3955	22	/	/	SYM
cord-006860-a3b8hyyr	3955	23	reliability	reliability	NN
cord-006860-a3b8hyyr	3955	24	of	of	IN
cord-006860-a3b8hyyr	3955	25	a	a	DT
cord-006860-a3b8hyyr	3955	26	protein	protein	NN
cord-006860-a3b8hyyr	3955	27	S	S	NNP
cord-006860-a3b8hyyr	3955	28	determination	determination	NN
cord-006860-a3b8hyyr	3955	29	.	.	.
cord-006860-a3b8hyyr	3956	1	In	in	IN
cord-006860-a3b8hyyr	3956	2	this	this	DT
cord-006860-a3b8hyyr	3956	3	study	study	NN
cord-006860-a3b8hyyr	3956	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	3956	5	evaluated	evaluate	VBD
cord-006860-a3b8hyyr	3956	6	the	the	DT
cord-006860-a3b8hyyr	3956	7	use	use	NN
cord-006860-a3b8hyyr	3956	8	of	of	IN
cord-006860-a3b8hyyr	3956	9	hormonal	hormonal	JJ
cord-006860-a3b8hyyr	3956	10	contraception	contraception	NN
cord-006860-a3b8hyyr	3956	11	on	on	IN
cord-006860-a3b8hyyr	3956	12	the	the	DT
cord-006860-a3b8hyyr	3956	13	parameters	parameter	NNS
cord-006860-a3b8hyyr	3956	14	protein	protein	NN
cord-006860-a3b8hyyr	3956	15	C	C	NNP
cord-006860-a3b8hyyr	3956	16	,	,	,
cord-006860-a3b8hyyr	3956	17	protein	protein	NN
cord-006860-a3b8hyyr	3956	18	S	s	NN
cord-006860-a3b8hyyr	3956	19	and	and	CC
cord-006860-a3b8hyyr	3956	20	PAl	PAl	NNS
cord-006860-a3b8hyyr	3956	21	.	.	.
cord-006860-a3b8hyyr	3957	1	Samples	sample	NNS
cord-006860-a3b8hyyr	3957	2	from	from	IN
cord-006860-a3b8hyyr	3957	3	71	71	CD
cord-006860-a3b8hyyr	3957	4	women	woman	NNS
cord-006860-a3b8hyyr	3957	5	with	with	IN
cord-006860-a3b8hyyr	3957	6	,	,	,
cord-006860-a3b8hyyr	3957	7	without	without	IN
cord-006860-a3b8hyyr	3957	8	hormonal	hormonal	JJ
cord-006860-a3b8hyyr	3957	9	contraception	contraception	NN
cord-006860-a3b8hyyr	3957	10	and	and	CC
cord-006860-a3b8hyyr	3957	11	in	in	IN
cord-006860-a3b8hyyr	3957	12	menopause	menopause	NN
cord-006860-a3b8hyyr	3957	13	were	be	VBD
cord-006860-a3b8hyyr	3957	14	assayed	assay	VBN
cord-006860-a3b8hyyr	3957	15	by	by	IN
cord-006860-a3b8hyyr	3957	16	coagulometric	coagulometric	NNP
cord-006860-a3b8hyyr	3957	17	(	(	-LRB-
cord-006860-a3b8hyyr	3957	18	protein	protein	NN
cord-006860-a3b8hyyr	3957	19	S	S	NNP
cord-006860-a3b8hyyr	3957	20	clotting	clotting	NN
cord-006860-a3b8hyyr	3957	21	test	test	NN
cord-006860-a3b8hyyr	3957	22	(	(	-LRB-
cord-006860-a3b8hyyr	3957	23	Behdngwerke	Behdngwerke	NNP
cord-006860-a3b8hyyr	3957	24	,	,	,
cord-006860-a3b8hyyr	3957	25	Marburg	Marburg	NNP
cord-006860-a3b8hyyr	3957	26	,	,	,
cord-006860-a3b8hyyr	3957	27	FRG	FRG	NNP
cord-006860-a3b8hyyr	3957	28	)	)	-RRB-
cord-006860-a3b8hyyr	3957	29	or	or	CC
cord-006860-a3b8hyyr	3957	30	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	3957	31	methods	method	NNS
cord-006860-a3b8hyyr	3957	32	(	(	-LRB-
cord-006860-a3b8hyyr	3957	33	protein	protein	NN
cord-006860-a3b8hyyr	3957	34	C	c	NN
cord-006860-a3b8hyyr	3957	35	activity	activity	NN
cord-006860-a3b8hyyr	3957	36	test	test	NN
cord-006860-a3b8hyyr	3957	37	and	and	CC
cord-006860-a3b8hyyr	3957	38	PAl	PAl	NNS
cord-006860-a3b8hyyr	3957	39	reagent	reagent	NN
cord-006860-a3b8hyyr	3957	40	from	from	IN
cord-006860-a3b8hyyr	3957	41	Behringwerke	Behringwerke	NNP
cord-006860-a3b8hyyr	3957	42	,	,	,
cord-006860-a3b8hyyr	3957	43	Marburg	Marburg	NNP
cord-006860-a3b8hyyr	3957	44	,	,	,
cord-006860-a3b8hyyr	3957	45	FRG	FRG	NNP
cord-006860-a3b8hyyr	3957	46	)	)	-RRB-
cord-006860-a3b8hyyr	3957	47	in	in	IN
cord-006860-a3b8hyyr	3957	48	double	double	JJ
cord-006860-a3b8hyyr	3957	49	determination	determination	NN
cord-006860-a3b8hyyr	3957	50	and	and	CC
cord-006860-a3b8hyyr	3957	51	were	be	VBD
cord-006860-a3b8hyyr	3957	52	compared	compare	VBN
cord-006860-a3b8hyyr	3957	53	with	with	IN
cord-006860-a3b8hyyr	3957	54	the	the	DT
cord-006860-a3b8hyyr	3957	55	reference	reference	NN
cord-006860-a3b8hyyr	3957	56	ranges	range	NNS
cord-006860-a3b8hyyr	3957	57	.	.	.
cord-006860-a3b8hyyr	3958	1	In	in	IN
cord-006860-a3b8hyyr	3958	2	addition	addition	NN
cord-006860-a3b8hyyr	3958	3	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	3958	4	time	time	NN
cord-006860-a3b8hyyr	3958	5	(	(	-LRB-
cord-006860-a3b8hyyr	3958	6	Thromborel	Thromborel	NNP
cord-006860-a3b8hyyr	3958	7	S	S	NNP
cord-006860-a3b8hyyr	3958	8	reagent	reagent	NN
cord-006860-a3b8hyyr	3958	9	)	)	-RRB-
cord-006860-a3b8hyyr	3958	10	and	and	CC
cord-006860-a3b8hyyr	3958	11	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3958	12	(	(	-LRB-
cord-006860-a3b8hyyr	3958	13	Multifibrin	Multifibrin	NNP
cord-006860-a3b8hyyr	3958	14	)	)	-RRB-
cord-006860-a3b8hyyr	3958	15	from	from	IN
cord-006860-a3b8hyyr	3958	16	Behringwerke	Behringwerke	NNP
cord-006860-a3b8hyyr	3958	17	,	,	,
cord-006860-a3b8hyyr	3958	18	Marburg	Marburg	NNP
cord-006860-a3b8hyyr	3958	19	,	,	,
cord-006860-a3b8hyyr	3958	20	FRG	FRG	NNP
cord-006860-a3b8hyyr	3958	21	,	,	,
cord-006860-a3b8hyyr	3958	22	and	and	CC
cord-006860-a3b8hyyr	3958	23	aPTT	aptt	CC
cord-006860-a3b8hyyr	3958	24	(	(	-LRB-
cord-006860-a3b8hyyr	3958	25	Actin	Actin	NNP
cord-006860-a3b8hyyr	3958	26	FS	fs	NN
cord-006860-a3b8hyyr	3958	27	reagent	reagent	NN
cord-006860-a3b8hyyr	3958	28	from	from	IN
cord-006860-a3b8hyyr	3958	29	Dade	Dade	NNP
cord-006860-a3b8hyyr	3958	30	corp	corp	NNP
cord-006860-a3b8hyyr	3958	31	.	.	NNP
cord-006860-a3b8hyyr	3958	32	,	,	,
cord-006860-a3b8hyyr	3958	33	Unterschlei6heim	Unterschlei6heim	NNP
cord-006860-a3b8hyyr	3958	34	,	,	,
cord-006860-a3b8hyyr	3958	35	FRG	FRG	NNP
cord-006860-a3b8hyyr	3958	36	)	)	-RRB-
cord-006860-a3b8hyyr	3958	37	were	be	VBD
cord-006860-a3b8hyyr	3958	38	determined	determine	VBN
cord-006860-a3b8hyyr	3958	39	.	.	.
cord-006860-a3b8hyyr	3959	1	In	in	IN
cord-006860-a3b8hyyr	3959	2	women	woman	NNS
cord-006860-a3b8hyyr	3959	3	using	use	VBG
cord-006860-a3b8hyyr	3959	4	hormonal	hormonal	JJ
cord-006860-a3b8hyyr	3959	5	contraceptives	contraceptive	NNS
cord-006860-a3b8hyyr	3959	6	(	(	-LRB-
cord-006860-a3b8hyyr	3959	7	p<0,01	p<0,01	NN
cord-006860-a3b8hyyr	3959	8	)	)	-RRB-
cord-006860-a3b8hyyr	3959	9	and	and	CC
cord-006860-a3b8hyyr	3959	10	in	in	IN
cord-006860-a3b8hyyr	3959	11	menopause	menopause	NN
cord-006860-a3b8hyyr	3959	12	(	(	-LRB-
cord-006860-a3b8hyyr	3959	13	p<0,05	p<0,05	NNP
cord-006860-a3b8hyyr	3959	14	)	)	-RRB-
cord-006860-a3b8hyyr	3959	15	protein	protein	NN
cord-006860-a3b8hyyr	3959	16	S	S	NNP
cord-006860-a3b8hyyr	3959	17	activity	activity	NN
cord-006860-a3b8hyyr	3959	18	was	be	VBD
cord-006860-a3b8hyyr	3959	19	significantly	significantly	RB
cord-006860-a3b8hyyr	3959	20	reduced	reduce	VBN
cord-006860-a3b8hyyr	3959	21	compared	compare	VBN
cord-006860-a3b8hyyr	3959	22	to	to	IN
cord-006860-a3b8hyyr	3959	23	other	other	JJ
cord-006860-a3b8hyyr	3959	24	women	woman	NNS
cord-006860-a3b8hyyr	3959	25	(	(	-LRB-
cord-006860-a3b8hyyr	3959	26	<	<	NNP
cord-006860-a3b8hyyr	3959	27	45	45	CD
cord-006860-a3b8hyyr	3959	28	years	year	NNS
cord-006860-a3b8hyyr	3959	29	)	)	-RRB-
cord-006860-a3b8hyyr	3959	30	while	while	IN
cord-006860-a3b8hyyr	3959	31	protein	protein	NN
cord-006860-a3b8hyyr	3959	32	C	C	NNP
cord-006860-a3b8hyyr	3959	33	acitivity	acitivity	NN
cord-006860-a3b8hyyr	3959	34	did	do	VBD
cord-006860-a3b8hyyr	3959	35	not	not	RB
cord-006860-a3b8hyyr	3959	36	change	change	VB
cord-006860-a3b8hyyr	3959	37	.	.	.
cord-006860-a3b8hyyr	3960	1	In	in	IN
cord-006860-a3b8hyyr	3960	2	menopausal	menopausal	JJ
cord-006860-a3b8hyyr	3960	3	women	woman	NNS
cord-006860-a3b8hyyr	3960	4	a	a	DT
cord-006860-a3b8hyyr	3960	5	higher	high	JJR
cord-006860-a3b8hyyr	3960	6	susceptibility	susceptibility	NN
cord-006860-a3b8hyyr	3960	7	to	to	IN
cord-006860-a3b8hyyr	3960	8	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	3960	9	was	be	VBD
cord-006860-a3b8hyyr	3960	10	supported	support	VBN
cord-006860-a3b8hyyr	3960	11	by	by	IN
cord-006860-a3b8hyyr	3960	12	an	an	DT
cord-006860-a3b8hyyr	3960	13	increase	increase	NN
cord-006860-a3b8hyyr	3960	14	of	of	IN
cord-006860-a3b8hyyr	3960	15	aPTT	aptt	NN
cord-006860-a3b8hyyr	3960	16	(	(	-LRB-
cord-006860-a3b8hyyr	3960	17	p<0,05	p<0,05	NNP
cord-006860-a3b8hyyr	3960	18	)	)	-RRB-
cord-006860-a3b8hyyr	3960	19	and	and	CC
cord-006860-a3b8hyyr	3960	20	fibronogen	fibronogen	NNP
cord-006860-a3b8hyyr	3960	21	(	(	-LRB-
cord-006860-a3b8hyyr	3960	22	p<0,01	p<0,01	NN
cord-006860-a3b8hyyr	3960	23	)	)	-RRB-
cord-006860-a3b8hyyr	3960	24	.	.	.
cord-006860-a3b8hyyr	3961	1	While	while	IN
cord-006860-a3b8hyyr	3961	2	there	there	EX
cord-006860-a3b8hyyr	3961	3	was	be	VBD
cord-006860-a3b8hyyr	3961	4	no	no	DT
cord-006860-a3b8hyyr	3961	5	change	change	NN
cord-006860-a3b8hyyr	3961	6	for	for	IN
cord-006860-a3b8hyyr	3961	7	PAl	PAl	NNS
cord-006860-a3b8hyyr	3961	8	,	,	,
cord-006860-a3b8hyyr	3961	9	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	3961	10	was	be	VBD
cord-006860-a3b8hyyr	3961	11	significantly	significantly	RB
cord-006860-a3b8hyyr	3961	12	lower	low	JJR
cord-006860-a3b8hyyr	3961	13	in	in	IN
cord-006860-a3b8hyyr	3961	14	women	woman	NNS
cord-006860-a3b8hyyr	3961	15	using	use	VBG
cord-006860-a3b8hyyr	3961	16	hormonal	hormonal	JJ
cord-006860-a3b8hyyr	3961	17	contraceptives	contraceptive	NNS
cord-006860-a3b8hyyr	3961	18	and	and	CC
cord-006860-a3b8hyyr	3961	19	in	in	IN
cord-006860-a3b8hyyr	3961	20	menopause	menopause	NN
cord-006860-a3b8hyyr	3961	21	(	(	-LRB-
cord-006860-a3b8hyyr	3961	22	p<0,05	p<0,05	NNP
cord-006860-a3b8hyyr	3961	23	)	)	-RRB-
cord-006860-a3b8hyyr	3961	24	.	.	.
cord-006860-a3b8hyyr	3962	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3962	2	could	could	MD
cord-006860-a3b8hyyr	3962	3	not	not	RB
cord-006860-a3b8hyyr	3962	4	observe	observe	VB
cord-006860-a3b8hyyr	3962	5	a	a	DT
cord-006860-a3b8hyyr	3962	6	higher	high	JJR
cord-006860-a3b8hyyr	3962	7	turnover	turnover	NN
cord-006860-a3b8hyyr	3962	8	of	of	IN
cord-006860-a3b8hyyr	3962	9	coagulation	coagulation	NN
cord-006860-a3b8hyyr	3962	10	and	and	CC
cord-006860-a3b8hyyr	3962	11	fibdnolytJc	fibdnolytjc	CD
cord-006860-a3b8hyyr	3962	12	system	system	NN
cord-006860-a3b8hyyr	3962	13	with	with	IN
cord-006860-a3b8hyyr	3962	14	hormonal	hormonal	JJ
cord-006860-a3b8hyyr	3962	15	contraception	contraception	NN
cord-006860-a3b8hyyr	3962	16	.	.	.
cord-006860-a3b8hyyr	3963	1	Noteworthy	Noteworthy	NNP
cord-006860-a3b8hyyr	3963	2	was	be	VBD
cord-006860-a3b8hyyr	3963	3	the	the	DT
cord-006860-a3b8hyyr	3963	4	occurence	occurence	NN
cord-006860-a3b8hyyr	3963	5	of	of	IN
cord-006860-a3b8hyyr	3963	6	low	low	JJ
cord-006860-a3b8hyyr	3963	7	(	(	-LRB-
cord-006860-a3b8hyyr	3963	8	<	<	XX
cord-006860-a3b8hyyr	3963	9	200	200	CD
cord-006860-a3b8hyyr	3963	10	mg	mg	NNP
cord-006860-a3b8hyyr	3963	11	/	/	SYM
cord-006860-a3b8hyyr	3963	12	dl	dl	NNP
cord-006860-a3b8hyyr	3963	13	)	)	-RRB-
cord-006860-a3b8hyyr	3963	14	and	and	CC
cord-006860-a3b8hyyr	3963	15	borderline	borderline	JJ
cord-006860-a3b8hyyr	3963	16	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	3963	17	(	(	-LRB-
cord-006860-a3b8hyyr	3963	18	max	max	NNP
cord-006860-a3b8hyyr	3963	19	.	.	.
cord-006860-a3b8hyyr	3963	20	220	220	CD
cord-006860-a3b8hyyr	3963	21	mg	mg	NNP
cord-006860-a3b8hyyr	3963	22	/	/	SYM
cord-006860-a3b8hyyr	3963	23	dl	dl	NNP
cord-006860-a3b8hyyr	3963	24	)	)	-RRB-
cord-006860-a3b8hyyr	3963	25	in	in	IN
cord-006860-a3b8hyyr	3963	26	40,9	40,9	CD
cord-006860-a3b8hyyr	3963	27	%	%	NN
cord-006860-a3b8hyyr	3963	28	of	of	IN
cord-006860-a3b8hyyr	3963	29	women	woman	NNS
cord-006860-a3b8hyyr	3963	30	res	re	NNS
cord-006860-a3b8hyyr	3963	31	.	.	.
cord-006860-a3b8hyyr	3964	1	in	in	IN
cord-006860-a3b8hyyr	3964	2	22,8	22,8	CD
cord-006860-a3b8hyyr	3964	3	%	%	NN
cord-006860-a3b8hyyr	3964	4	of	of	IN
cord-006860-a3b8hyyr	3964	5	women	woman	NNS
cord-006860-a3b8hyyr	3964	6	(	(	-LRB-
cord-006860-a3b8hyyr	3964	7	together	together	RB
cord-006860-a3b8hyyr	3964	8	with	with	IN
cord-006860-a3b8hyyr	3964	9	borderline	borderline	JJ
cord-006860-a3b8hyyr	3964	10	aPTT	aPTT	NNS
cord-006860-a3b8hyyr	3964	11	)	)	-RRB-
cord-006860-a3b8hyyr	3964	12	who	who	WP
cord-006860-a3b8hyyr	3964	13	had	have	VBD
cord-006860-a3b8hyyr	3964	14	an	an	DT
cord-006860-a3b8hyyr	3964	15	individuell	individuell	JJ
cord-006860-a3b8hyyr	3964	16	risk	risk	NN
cord-006860-a3b8hyyr	3964	17	for	for	IN
cord-006860-a3b8hyyr	3964	18	arterial	arterial	JJ
cord-006860-a3b8hyyr	3964	19	disease	disease	NN
cord-006860-a3b8hyyr	3964	20	.	.	.
cord-006860-a3b8hyyr	3965	1	Protein	Protein	NNP
cord-006860-a3b8hyyr	3965	2	S	S	NNP
cord-006860-a3b8hyyr	3965	3	Protein	Protein	NNP
cord-006860-a3b8hyyr	3965	4	C	C	NNP
cord-006860-a3b8hyyr	3965	5	Fibdno	Fibdno	NNP
cord-006860-a3b8hyyr	3965	6	~	~	NFP
cord-006860-a3b8hyyr	3965	7	en	en	NN
cord-006860-a3b8hyyr	3965	8	aPTT	aPTT	NNP
cord-006860-a3b8hyyr	3965	9	Plasminog~	plasminog~	NN
cord-006860-a3b8hyyr	3965	10	without	without	IN
cord-006860-a3b8hyyr	3965	11	HCC	HCC	NNP
cord-006860-a3b8hyyr	3966	1	109,1-+13,6	109,1-+13,6	LS
cord-006860-a3b8hyyr	3966	2	78,3-+14,1	78,3-+14,1	CD
cord-006860-a3b8hyyr	3966	3	255,0-+14,0	255,0-+14,0	CD
cord-006860-a3b8hyyr	3966	4	36	36	CD
cord-006860-a3b8hyyr	3966	5	,	,	,
cord-006860-a3b8hyyr	3966	6	[	[	-LRB-
cord-006860-a3b8hyyr	3966	7	2	2	CD
cord-006860-a3b8hyyr	3966	8	]	]	-RRB-
cord-006860-a3b8hyyr	3966	9	[	[	-LRB-
cord-006860-a3b8hyyr	3966	10	3	3	CD
cord-006860-a3b8hyyr	3966	11	]	]	-RRB-
cord-006860-a3b8hyyr	3966	12	[	[	-LRB-
cord-006860-a3b8hyyr	3966	13	4	4	CD
cord-006860-a3b8hyyr	3966	14	]	]	-RRB-
cord-006860-a3b8hyyr	3967	1	[	[	-LRB-
cord-006860-a3b8hyyr	3967	2	5	5	CD
cord-006860-a3b8hyyr	3967	3	]	]	-RRB-
cord-006860-a3b8hyyr	3967	4	4	4	CD
cord-006860-a3b8hyyr	3967	5	24	24	CD
cord-006860-a3b8hyyr	3967	6	,	,	,
cord-006860-a3b8hyyr	3967	7	[	[	-LRB-
cord-006860-a3b8hyyr	3967	8	0	0	NFP
cord-006860-a3b8hyyr	3967	9	]	]	-RRB-
cord-006860-a3b8hyyr	3968	1	[	[	-LRB-
cord-006860-a3b8hyyr	3968	2	1	1	CD
cord-006860-a3b8hyyr	3968	3	]	]	-RRB-
cord-006860-a3b8hyyr	3968	4	[	[	-LRB-
cord-006860-a3b8hyyr	3968	5	2	2	CD
cord-006860-a3b8hyyr	3968	6	]	]	-RRB-
cord-006860-a3b8hyyr	3968	7	[	[	-LRB-
cord-006860-a3b8hyyr	3968	8	3	3	CD
cord-006860-a3b8hyyr	3968	9	]	]	-RRB-
cord-006860-a3b8hyyr	3968	10	[	[	-LRB-
cord-006860-a3b8hyyr	3968	11	4	4	CD
cord-006860-a3b8hyyr	3968	12	]	]	-RRB-
cord-006860-a3b8hyyr	3968	13	[	[	-LRB-
cord-006860-a3b8hyyr	3968	14	5	5	CD
cord-006860-a3b8hyyr	3968	15	]	]	-RRB-
cord-006860-a3b8hyyr	3968	16	[	[	-LRB-
cord-006860-a3b8hyyr	3968	17	6	6	CD
cord-006860-a3b8hyyr	3968	18	]	]	-RRB-
cord-006860-a3b8hyyr	3968	19	[	[	-LRB-
cord-006860-a3b8hyyr	3968	20	7	7	CD
cord-006860-a3b8hyyr	3968	21	]	]	-RRB-
cord-006860-a3b8hyyr	3969	1	[	[	-LRB-
cord-006860-a3b8hyyr	3969	2	8	8	CD
cord-006860-a3b8hyyr	3969	3	]	]	-RRB-
cord-006860-a3b8hyyr	3969	4	[	[	-LRB-
cord-006860-a3b8hyyr	3969	5	9	9	CD
cord-006860-a3b8hyyr	3969	6	]	]	-RRB-
cord-006860-a3b8hyyr	3969	7	[	[	-LRB-
cord-006860-a3b8hyyr	3969	8	10	10	CD
cord-006860-a3b8hyyr	3969	9	]	]	-RRB-
cord-006860-a3b8hyyr	3970	1	[	[	-LRB-
cord-006860-a3b8hyyr	3970	2	11	11	CD
cord-006860-a3b8hyyr	3970	3	]	]	-RRB-
cord-006860-a3b8hyyr	3970	4	[	[	-LRB-
cord-006860-a3b8hyyr	3970	5	12	12	CD
cord-006860-a3b8hyyr	3970	6	]	]	-RRB-
cord-006860-a3b8hyyr	3970	7	2	2	CD
cord-006860-a3b8hyyr	3970	8	with	with	IN
cord-006860-a3b8hyyr	3970	9	HCC	HCC	NNP
cord-006860-a3b8hyyr	3970	10	85	85	CD
cord-006860-a3b8hyyr	3970	11	,	,	,
cord-006860-a3b8hyyr	3970	12	[	[	-LRB-
cord-006860-a3b8hyyr	3970	13	8	8	CD
cord-006860-a3b8hyyr	3970	14	]	]	-RRB-
cord-006860-a3b8hyyr	3970	15	[	[	-LRB-
cord-006860-a3b8hyyr	3970	16	9	9	CD
cord-006860-a3b8hyyr	3970	17	]	]	-RRB-
cord-006860-a3b8hyyr	3970	18	[	[	-LRB-
cord-006860-a3b8hyyr	3970	19	10	10	CD
cord-006860-a3b8hyyr	3970	20	]	]	-RRB-
cord-006860-a3b8hyyr	3970	21	[	[	-LRB-
cord-006860-a3b8hyyr	3970	22	11	11	CD
cord-006860-a3b8hyyr	3970	23	]	]	-RRB-
cord-006860-a3b8hyyr	3970	24	[	[	-LRB-
cord-006860-a3b8hyyr	3970	25	12	12	CD
cord-006860-a3b8hyyr	3970	26	]	]	-RRB-
cord-006860-a3b8hyyr	3970	27	[	[	-LRB-
cord-006860-a3b8hyyr	3970	28	13	13	CD
cord-006860-a3b8hyyr	3970	29	]	]	-RRB-
cord-006860-a3b8hyyr	3971	1	[	[	-LRB-
cord-006860-a3b8hyyr	3971	2	14	14	CD
cord-006860-a3b8hyyr	3971	3	]	]	-RRB-
cord-006860-a3b8hyyr	3972	1	[	[	-LRB-
cord-006860-a3b8hyyr	3972	2	15	15	CD
cord-006860-a3b8hyyr	3972	3	]	]	-RRB-
cord-006860-a3b8hyyr	3972	4	[	[	-LRB-
cord-006860-a3b8hyyr	3972	5	16	16	CD
cord-006860-a3b8hyyr	3972	6	]	]	-RRB-
cord-006860-a3b8hyyr	3972	7	[	[	-LRB-
cord-006860-a3b8hyyr	3972	8	17	17	CD
cord-006860-a3b8hyyr	3972	9	]	]	-RRB-
cord-006860-a3b8hyyr	3972	10	2	2	CD
cord-006860-a3b8hyyr	3972	11	78	78	CD
cord-006860-a3b8hyyr	3972	12	,	,	,
cord-006860-a3b8hyyr	3972	13	5±12	5±12	CD
cord-006860-a3b8hyyr	3972	14	,	,	,
cord-006860-a3b8hyyr	3972	15	0	0	CD
cord-006860-a3b8hyyr	3972	16	253	253	CD
cord-006860-a3b8hyyr	3972	17	,	,	,
cord-006860-a3b8hyyr	3972	18	8.+24	8.+24	CD
cord-006860-a3b8hyyr	3972	19	,	,	,
cord-006860-a3b8hyyr	3973	1	1	1	CD
cord-006860-a3b8hyyr	3973	2	35	35	CD
cord-006860-a3b8hyyr	3973	3	,	,	,
cord-006860-a3b8hyyr	3973	4	[	[	-LRB-
cord-006860-a3b8hyyr	3973	5	2	2	CD
cord-006860-a3b8hyyr	3973	6	]	]	-RRB-
cord-006860-a3b8hyyr	3973	7	[	[	-LRB-
cord-006860-a3b8hyyr	3973	8	3	3	CD
cord-006860-a3b8hyyr	3973	9	]	]	-RRB-
cord-006860-a3b8hyyr	3973	10	[	[	-LRB-
cord-006860-a3b8hyyr	3973	11	4	4	CD
cord-006860-a3b8hyyr	3973	12	]	]	-RRB-
cord-006860-a3b8hyyr	3973	13	8	8	CD
cord-006860-a3b8hyyr	3973	14	14	14	CD
cord-006860-a3b8hyyr	3973	15	,	,	,
cord-006860-a3b8hyyr	3973	16	9	9	CD
cord-006860-a3b8hyyr	3973	17	menopause	menopause	NN
cord-006860-a3b8hyyr	3973	18	90	90	CD
cord-006860-a3b8hyyr	3973	19	,	,	,
cord-006860-a3b8hyyr	3973	20	3	3	CD
cord-006860-a3b8hyyr	3973	21	+	+	SYM
cord-006860-a3b8hyyr	3973	22	97	97	CD
cord-006860-a3b8hyyr	3973	23	,	,	,
cord-006860-a3b8hyyr	3973	24	6	6	CD
cord-006860-a3b8hyyr	3973	25	87	87	CD
cord-006860-a3b8hyyr	3973	26	,	,	,
cord-006860-a3b8hyyr	3973	27	4±41	4±41	CD
cord-006860-a3b8hyyr	3973	28	,	,	,
cord-006860-a3b8hyyr	3973	29	4	4	CD
cord-006860-a3b8hyyr	3973	30	307	307	CD
cord-006860-a3b8hyyr	3973	31	,	,	,
cord-006860-a3b8hyyr	3973	32	05:57	05:57	CD
cord-006860-a3b8hyyr	3973	33	,	,	,
cord-006860-a3b8hyyr	3973	34	6	6	CD
cord-006860-a3b8hyyr	3973	35	39	39	CD
cord-006860-a3b8hyyr	3973	36	,	,	,
cord-006860-a3b8hyyr	3973	37	[	[	-LRB-
cord-006860-a3b8hyyr	3973	38	8	8	CD
cord-006860-a3b8hyyr	3973	39	]	]	-RRB-
cord-006860-a3b8hyyr	3973	40	[	[	-LRB-
cord-006860-a3b8hyyr	3973	41	9	9	CD
cord-006860-a3b8hyyr	3973	42	]	]	-RRB-
cord-006860-a3b8hyyr	3973	43	[	[	-LRB-
cord-006860-a3b8hyyr	3973	44	10	10	CD
cord-006860-a3b8hyyr	3973	45	]	]	-RRB-
cord-006860-a3b8hyyr	3973	46	0	0	CD
cord-006860-a3b8hyyr	3973	47	12	12	CD
cord-006860-a3b8hyyr	3973	48	,	,	,
cord-006860-a3b8hyyr	3973	49	6	6	CD
cord-006860-a3b8hyyr	3973	50	HCC=	hcc=	CD
cord-006860-a3b8hyyr	3973	51	hormonal	hormonal	JJ
cord-006860-a3b8hyyr	3973	52	contraception	contraception	NN
cord-006860-a3b8hyyr	3973	53	Hemostatic	hemostatic	NN
cord-006860-a3b8hyyr	3973	54	parameters	parameter	NNS
cord-006860-a3b8hyyr	3973	55	in	in	IN
cord-006860-a3b8hyyr	3973	56	a	a	DT
cord-006860-a3b8hyyr	3973	57	patient	patient	NN
cord-006860-a3b8hyyr	3973	58	undergoing	undergo	VBG
cord-006860-a3b8hyyr	3973	59	bone	bone	NN
cord-006860-a3b8hyyr	3973	60	marrow	marrow	NN
cord-006860-a3b8hyyr	3973	61	and	and	CC
cord-006860-a3b8hyyr	3973	62	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	3973	63	liver	liver	NN
cord-006860-a3b8hyyr	3973	64	transplantation	transplantation	NN
cord-006860-a3b8hyyr	3973	65	due	due	IN
cord-006860-a3b8hyyr	3973	66	to	to	IN
cord-006860-a3b8hyyr	3973	67	veno	veno	NNP
cord-006860-a3b8hyyr	3973	68	-	-	HYPH
cord-006860-a3b8hyyr	3973	69	occlusive	occlusive	JJ
cord-006860-a3b8hyyr	3973	70	disease	disease	NN
cord-006860-a3b8hyyr	3973	71	C.	C.	NNP
cord-006860-a3b8hyyr	3973	72	Salat	Salat	NNP
cord-006860-a3b8hyyr	3973	73	1	1	CD
cord-006860-a3b8hyyr	3974	1	,	,	,
cord-006860-a3b8hyyr	3974	2	,	,	,
cord-006860-a3b8hyyr	3974	3	E.	E.	NNP
cord-006860-a3b8hyyr	3974	4	Holler	Holler	NNP
cord-006860-a3b8hyyr	3974	5	t,3	t,3	NNP
cord-006860-a3b8hyyr	3974	6	,	,	,
cord-006860-a3b8hyyr	3974	7	HI	HI	NNP
cord-006860-a3b8hyyr	3974	8	.	.	.
cord-006860-a3b8hyyr	3975	1	Kolbl	Kolbl	NNP
cord-006860-a3b8hyyr	3975	2	,	,	,
cord-006860-a3b8hyyr	3975	3	3	3	CD
cord-006860-a3b8hyyr	3975	4	,	,	,
cord-006860-a3b8hyyr	3975	5	B.	B.	NNP
cord-006860-a3b8hyyr	3975	6	Reinhardt	Reinhardt	NNP
cord-006860-a3b8hyyr	3975	7	l	l	NNP
cord-006860-a3b8hyyr	3975	8	,	,	,
cord-006860-a3b8hyyr	3975	9	R.	R.	NNP
cord-006860-a3b8hyyr	3975	10	Pihusch	Pihusch	NNP
cord-006860-a3b8hyyr	3975	11	1	1	CD
cord-006860-a3b8hyyr	3975	12	,	,	,
cord-006860-a3b8hyyr	3975	13	P.	P.	NNP
cord-006860-a3b8hyyr	3975	14	G0hring	G0hring	NNP
cord-006860-a3b8hyyr	3975	15	2	2	CD
cord-006860-a3b8hyyr	3975	16	,	,	,
cord-006860-a3b8hyyr	3975	17	S.	S.	NNP
cord-006860-a3b8hyyr	3975	18	Poley	Poley	NNP
cord-006860-a3b8hyyr	3975	19	2	2	CD
cord-006860-a3b8hyyr	3975	20	,	,	,
cord-006860-a3b8hyyr	3975	21	E.	E.	NNP
cord-006860-a3b8hyyr	3975	22	Hiller	Hiller	NNP
cord-006860-a3b8hyyr	3975	23	1	1	CD
cord-006860-a3b8hyyr	3975	24	l	l	NN
cord-006860-a3b8hyyr	3975	25	=	=	SYM
cord-006860-a3b8hyyr	3975	26	Med	Med	NNP
cord-006860-a3b8hyyr	3975	27	.	.	.
cord-006860-a3b8hyyr	3975	28	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	3975	29	IIi	IIi	NNP
cord-006860-a3b8hyyr	3975	30	,	,	,
cord-006860-a3b8hyyr	3975	31	2	2	CD
cord-006860-a3b8hyyr	3976	1	=	=	SYM
cord-006860-a3b8hyyr	3976	2	Institut	Institut	NNP
cord-006860-a3b8hyyr	3976	3	flit	flit	VB
cord-006860-a3b8hyyr	3976	4	Klin	Klin	NNP
cord-006860-a3b8hyyr	3976	5	.	.	.
cord-006860-a3b8hyyr	3977	1	Chemie	Chemie	NNP
cord-006860-a3b8hyyr	3977	2	,	,	,
cord-006860-a3b8hyyr	3977	3	Klinikum	Klinikum	NNP
cord-006860-a3b8hyyr	3977	4	Grosshadern	Grosshadern	NNP
cord-006860-a3b8hyyr	3977	5	der	der	NNP
cord-006860-a3b8hyyr	3977	6	Ludwig	Ludwig	NNP
cord-006860-a3b8hyyr	3977	7	-	-	HYPH
cord-006860-a3b8hyyr	3977	8	Maximilians	Maximilians	NNP
cord-006860-a3b8hyyr	3977	9	-	-	HYPH
cord-006860-a3b8hyyr	3977	10	Universit	Universit	NNP
cord-006860-a3b8hyyr	3978	1	~tt	~tt	NNP
cord-006860-a3b8hyyr	3978	2	Mfinchen	Mfinchen	NNP
cord-006860-a3b8hyyr	3978	3	,	,	,
cord-006860-a3b8hyyr	3978	4	3	3	CD
cord-006860-a3b8hyyr	3978	5	=	=	SYM
cord-006860-a3b8hyyr	3978	6	H	h	NN
cord-006860-a3b8hyyr	3979	1	~tmatologikum	~tmatologikum	XX
cord-006860-a3b8hyyr	3979	2	der	der	NNP
cord-006860-a3b8hyyr	3979	3	GSF	GSF	NNP
cord-006860-a3b8hyyr	3979	4	A	A	NNP
cord-006860-a3b8hyyr	3979	5	40	40	CD
cord-006860-a3b8hyyr	3979	6	year	year	NN
cord-006860-a3b8hyyr	3979	7	old	old	JJ
cord-006860-a3b8hyyr	3979	8	patient	patient	NN
cord-006860-a3b8hyyr	3979	9	suffering	suffer	VBG
cord-006860-a3b8hyyr	3979	10	from	from	IN
cord-006860-a3b8hyyr	3979	11	ALL	all	DT
cord-006860-a3b8hyyr	3979	12	received	receive	VBN
cord-006860-a3b8hyyr	3979	13	allogeneic	allogeneic	NN
cord-006860-a3b8hyyr	3979	14	bone	bone	NN
cord-006860-a3b8hyyr	3979	15	marrow	marrow	NN
cord-006860-a3b8hyyr	3979	16	transplantation	transplantation	NN
cord-006860-a3b8hyyr	3979	17	(	(	-LRB-
cord-006860-a3b8hyyr	3979	18	BMT	BMT	NNP
cord-006860-a3b8hyyr	3979	19	)	)	-RRB-
cord-006860-a3b8hyyr	3979	20	.	.	.
cord-006860-a3b8hyyr	3980	1	After	after	IN
cord-006860-a3b8hyyr	3980	2	an	an	DT
cord-006860-a3b8hyyr	3980	3	uncomplicated	uncomplicated	JJ
cord-006860-a3b8hyyr	3980	4	early	early	JJ
cord-006860-a3b8hyyr	3980	5	posttransplant	posttransplant	NN
cord-006860-a3b8hyyr	3980	6	period	period	NN
cord-006860-a3b8hyyr	3980	7	the	the	DT
cord-006860-a3b8hyyr	3980	8	patient	patient	NN
cord-006860-a3b8hyyr	3980	9	was	be	VBD
cord-006860-a3b8hyyr	3980	10	dismissed	dismiss	VBN
cord-006860-a3b8hyyr	3980	11	after	after	IN
cord-006860-a3b8hyyr	3980	12	4	4	CD
cord-006860-a3b8hyyr	3980	13	weeks	week	NNS
cord-006860-a3b8hyyr	3980	14	.	.	.
cord-006860-a3b8hyyr	3981	1	A	a	DT
cord-006860-a3b8hyyr	3981	2	bilirubin	bilirubin	NN
cord-006860-a3b8hyyr	3981	3	rise	rise	NN
cord-006860-a3b8hyyr	3981	4	with	with	IN
cord-006860-a3b8hyyr	3981	5	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	3981	6	liver	liver	NN
cord-006860-a3b8hyyr	3981	7	failure	failure	NN
cord-006860-a3b8hyyr	3981	8	was	be	VBD
cord-006860-a3b8hyyr	3981	9	observed	observe	VBN
cord-006860-a3b8hyyr	3981	10	during	during	IN
cord-006860-a3b8hyyr	3981	11	the	the	DT
cord-006860-a3b8hyyr	3981	12	following	follow	VBG
cord-006860-a3b8hyyr	3981	13	weeks	week	NNS
cord-006860-a3b8hyyr	3981	14	.	.	.
cord-006860-a3b8hyyr	3982	1	According	accord	VBG
cord-006860-a3b8hyyr	3982	2	to	to	IN
cord-006860-a3b8hyyr	3982	3	biopsy	biopsy	NN
cord-006860-a3b8hyyr	3982	4	proven	prove	VBN
cord-006860-a3b8hyyr	3982	5	hepatic	hepatic	JJ
cord-006860-a3b8hyyr	3982	6	veno	veno	NNP
cord-006860-a3b8hyyr	3982	7	-	-	HYPH
cord-006860-a3b8hyyr	3982	8	occlusive	occlusive	JJ
cord-006860-a3b8hyyr	3982	9	disease	disease	NN
cord-006860-a3b8hyyr	3982	10	(	(	-LRB-
cord-006860-a3b8hyyr	3982	11	VOD	VOD	NNP
cord-006860-a3b8hyyr	3982	12	)	)	-RRB-
cord-006860-a3b8hyyr	3982	13	liver	liver	NN
cord-006860-a3b8hyyr	3982	14	transplantation	transplantation	NN
cord-006860-a3b8hyyr	3982	15	was	be	VBD
cord-006860-a3b8hyyr	3982	16	performed	perform	VBN
cord-006860-a3b8hyyr	3982	17	on	on	IN
cord-006860-a3b8hyyr	3982	18	day	day	NN
cord-006860-a3b8hyyr	3982	19	79	79	CD
cord-006860-a3b8hyyr	3982	20	.	.	.
cord-006860-a3b8hyyr	3983	1	Unfortunately	unfortunately	RB
cord-006860-a3b8hyyr	3983	2	the	the	DT
cord-006860-a3b8hyyr	3983	3	patient	patient	NN
cord-006860-a3b8hyyr	3983	4	died	die	VBD
cord-006860-a3b8hyyr	3983	5	on	on	IN
cord-006860-a3b8hyyr	3983	6	day	day	NN
cord-006860-a3b8hyyr	3983	7	140	140	CD
cord-006860-a3b8hyyr	3983	8	due	due	IN
cord-006860-a3b8hyyr	3983	9	to	to	IN
cord-006860-a3b8hyyr	3983	10	aspergillosis	aspergillosis	NNP
cord-006860-a3b8hyyr	3983	11	.	.	.
cord-006860-a3b8hyyr	3984	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	3984	2	monitored	monitor	VBD
cord-006860-a3b8hyyr	3984	3	levels	level	NNS
cord-006860-a3b8hyyr	3984	4	of	of	IN
cord-006860-a3b8hyyr	3984	5	protein	protein	NN
cord-006860-a3b8hyyr	3984	6	C	c	NN
cord-006860-a3b8hyyr	3984	7	(	(	-LRB-
cord-006860-a3b8hyyr	3984	8	PC	PC	NNP
cord-006860-a3b8hyyr	3984	9	)	)	-RRB-
cord-006860-a3b8hyyr	3984	10	and	and	CC
cord-006860-a3b8hyyr	3984	11	S	S	NNP
cord-006860-a3b8hyyr	3984	12	(	(	-LRB-
cord-006860-a3b8hyyr	3984	13	PS	PS	NNP
cord-006860-a3b8hyyr	3984	14	)	)	-RRB-
cord-006860-a3b8hyyr	3984	15	as	as	RB
cord-006860-a3b8hyyr	3984	16	well	well	RB
cord-006860-a3b8hyyr	3984	17	as	as	IN
cord-006860-a3b8hyyr	3984	18	PALl	PALl	NNS
cord-006860-a3b8hyyr	3984	19	during	during	IN
cord-006860-a3b8hyyr	3984	20	the	the	DT
cord-006860-a3b8hyyr	3984	21	pre	pre	JJ
cord-006860-a3b8hyyr	3984	22	-	-	JJ
cord-006860-a3b8hyyr	3984	23	and	and	CC
cord-006860-a3b8hyyr	3984	24	posttranspiant	posttranspiant	NN
cord-006860-a3b8hyyr	3984	25	period	period	NN
cord-006860-a3b8hyyr	3984	26	.	.	.
cord-006860-a3b8hyyr	3985	1	PAL1	pal1	JJ
cord-006860-a3b8hyyr	3985	2	level	level	NN
cord-006860-a3b8hyyr	3985	3	was	be	VBD
cord-006860-a3b8hyyr	3985	4	normal	normal	JJ
cord-006860-a3b8hyyr	3986	1	(	(	-LRB-
cord-006860-a3b8hyyr	3986	2	<	<	NNP
cord-006860-a3b8hyyr	3986	3	43	43	CD
cord-006860-a3b8hyyr	3986	4	ng	ng	NNP
cord-006860-a3b8hyyr	3986	5	/	/	SYM
cord-006860-a3b8hyyr	3986	6	ml	ml	NN
cord-006860-a3b8hyyr	3986	7	)	)	-RRB-
cord-006860-a3b8hyyr	3987	1	during	during	IN
cord-006860-a3b8hyyr	3987	2	the	the	DT
cord-006860-a3b8hyyr	3987	3	first	first	JJ
cord-006860-a3b8hyyr	3987	4	4	4	CD
cord-006860-a3b8hyyr	3987	5	weeks	week	NNS
cord-006860-a3b8hyyr	3987	6	after	after	IN
cord-006860-a3b8hyyr	3987	7	BMT	BMT	NNP
cord-006860-a3b8hyyr	3987	8	but	but	CC
cord-006860-a3b8hyyr	3987	9	increased	increase	VBD
cord-006860-a3b8hyyr	3987	10	with	with	IN
cord-006860-a3b8hyyr	3987	11	the	the	DT
cord-006860-a3b8hyyr	3987	12	manifestation	manifestation	NN
cord-006860-a3b8hyyr	3987	13	of	of	IN
cord-006860-a3b8hyyr	3987	14	VOD	VOD	NNP
cord-006860-a3b8hyyr	3987	15	(	(	-LRB-
cord-006860-a3b8hyyr	3987	16	317.5	317.5	CD
cord-006860-a3b8hyyr	3987	17	ng	ng	NNP
cord-006860-a3b8hyyr	3987	18	/	/	SYM
cord-006860-a3b8hyyr	3987	19	ml	ml	NN
cord-006860-a3b8hyyr	3987	20	on	on	IN
cord-006860-a3b8hyyr	3987	21	day	day	NN
cord-006860-a3b8hyyr	3987	22	47	47	CD
cord-006860-a3b8hyyr	3987	23	)	)	-RRB-
cord-006860-a3b8hyyr	3987	24	.	.	.
cord-006860-a3b8hyyr	3988	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	3988	2	reached	reach	VBD
cord-006860-a3b8hyyr	3988	3	its	-PRON-	PRP$
cord-006860-a3b8hyyr	3988	4	peak	peak	NN
cord-006860-a3b8hyyr	3988	5	immediately	immediately	RB
cord-006860-a3b8hyyr	3988	6	before	before	IN
cord-006860-a3b8hyyr	3988	7	liver	liver	NN
cord-006860-a3b8hyyr	3988	8	transplantation	transplantation	NN
cord-006860-a3b8hyyr	3988	9	(	(	-LRB-
cord-006860-a3b8hyyr	3988	10	547.6	547.6	CD
cord-006860-a3b8hyyr	3988	11	ng	ng	NN
cord-006860-a3b8hyyr	3988	12	/	/	SYM
cord-006860-a3b8hyyr	3988	13	ml	ml	NN
cord-006860-a3b8hyyr	3988	14	)	)	-RRB-
cord-006860-a3b8hyyr	3988	15	and	and	CC
cord-006860-a3b8hyyr	3988	16	returned	return	VBD
cord-006860-a3b8hyyr	3988	17	to	to	IN
cord-006860-a3b8hyyr	3988	18	normal	normal	JJ
cord-006860-a3b8hyyr	3988	19	levels	level	NNS
cord-006860-a3b8hyyr	3988	20	within	within	IN
cord-006860-a3b8hyyr	3988	21	the	the	DT
cord-006860-a3b8hyyr	3988	22	next	next	JJ
cord-006860-a3b8hyyr	3988	23	few	few	JJ
cord-006860-a3b8hyyr	3988	24	days	day	NNS
cord-006860-a3b8hyyr	3988	25	.	.	.
cord-006860-a3b8hyyr	3989	1	PC	pc	NN
cord-006860-a3b8hyyr	3989	2	levels	level	NNS
cord-006860-a3b8hyyr	3989	3	which	which	WDT
cord-006860-a3b8hyyr	3989	4	were	be	VBD
cord-006860-a3b8hyyr	3989	5	normal	normal	JJ
cord-006860-a3b8hyyr	3989	6	before	before	IN
cord-006860-a3b8hyyr	3989	7	BMT	BMT	NNP
cord-006860-a3b8hyyr	3989	8	decreased	decrease	VBD
cord-006860-a3b8hyyr	3989	9	prior	prior	RB
cord-006860-a3b8hyyr	3989	10	to	to	IN
cord-006860-a3b8hyyr	3989	11	clinical	clinical	JJ
cord-006860-a3b8hyyr	3989	12	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	3989	13	of	of	IN
cord-006860-a3b8hyyr	3989	14	VOD	VOD	NNP
cord-006860-a3b8hyyr	3989	15	and	and	CC
cord-006860-a3b8hyyr	3989	16	were	be	VBD
cord-006860-a3b8hyyr	3989	17	normal	normal	JJ
cord-006860-a3b8hyyr	3989	18	after	after	IN
cord-006860-a3b8hyyr	3989	19	liver	liver	NN
cord-006860-a3b8hyyr	3989	20	transplantation	transplantation	NN
cord-006860-a3b8hyyr	3989	21	.	.	.
cord-006860-a3b8hyyr	3990	1	PS	PS	NNP
cord-006860-a3b8hyyr	3990	2	levels	level	NNS
cord-006860-a3b8hyyr	3990	3	lay	lie	VBD
cord-006860-a3b8hyyr	3990	4	within	within	IN
cord-006860-a3b8hyyr	3990	5	the	the	DT
cord-006860-a3b8hyyr	3990	6	normal	normal	JJ
cord-006860-a3b8hyyr	3990	7	range	range	NN
cord-006860-a3b8hyyr	3990	8	at	at	IN
cord-006860-a3b8hyyr	3990	9	all	all	DT
cord-006860-a3b8hyyr	3990	10	timepoints	timepoint	NNS
cord-006860-a3b8hyyr	3990	11	.	.	.
cord-006860-a3b8hyyr	3991	1	VWF	VWF	NNP
cord-006860-a3b8hyyr	3991	2	was	be	VBD
cord-006860-a3b8hyyr	3991	3	elevated	elevate	VBN
cord-006860-a3b8hyyr	3991	4	before	before	IN
cord-006860-a3b8hyyr	3991	5	BMT	BMT	NNP
cord-006860-a3b8hyyr	3991	6	(	(	-LRB-
cord-006860-a3b8hyyr	3991	7	240	240	CD
cord-006860-a3b8hyyr	3991	8	%	%	NN
cord-006860-a3b8hyyr	3991	9	)	)	-RRB-
cord-006860-a3b8hyyr	3991	10	and	and	CC
cord-006860-a3b8hyyr	3991	11	remained	remain	VBD
cord-006860-a3b8hyyr	3991	12	relatively	relatively	RB
cord-006860-a3b8hyyr	3991	13	stable	stable	JJ
cord-006860-a3b8hyyr	3991	14	during	during	IN
cord-006860-a3b8hyyr	3991	15	the	the	DT
cord-006860-a3b8hyyr	3991	16	whole	whole	JJ
cord-006860-a3b8hyyr	3991	17	investigatonal	investigatonal	JJ
cord-006860-a3b8hyyr	3991	18	period	period	NN
cord-006860-a3b8hyyr	3991	19	ranging	range	VBG
cord-006860-a3b8hyyr	3991	20	from	from	IN
cord-006860-a3b8hyyr	3991	21	170	170	CD
cord-006860-a3b8hyyr	3991	22	to	to	TO
cord-006860-a3b8hyyr	3991	23	260	260	CD
cord-006860-a3b8hyyr	3991	24	%	%	NN
cord-006860-a3b8hyyr	3991	25	.	.	.
cord-006860-a3b8hyyr	3992	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	3992	2	is	be	VBZ
cord-006860-a3b8hyyr	3992	3	assumed	assume	VBN
cord-006860-a3b8hyyr	3992	4	that	that	IN
cord-006860-a3b8hyyr	3992	5	VOD	VOD	NNP
cord-006860-a3b8hyyr	3992	6	is	be	VBZ
cord-006860-a3b8hyyr	3992	7	initiated	initiate	VBN
cord-006860-a3b8hyyr	3992	8	by	by	IN
cord-006860-a3b8hyyr	3992	9	an	an	DT
cord-006860-a3b8hyyr	3992	10	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	3992	11	cell	cell	NN
cord-006860-a3b8hyyr	3992	12	injury	injury	NN
cord-006860-a3b8hyyr	3993	1	-possibly	-possibly	RB
cord-006860-a3b8hyyr	3993	2	due	due	JJ
cord-006860-a3b8hyyr	3993	3	to	to	IN
cord-006860-a3b8hyyr	3993	4	radiochemotherapy	radiochemotherapy	NNP
cord-006860-a3b8hyyr	3994	1	-and	-and	:
cord-006860-a3b8hyyr	3994	2	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	3994	3	hypercoagulability	hypercoagulability	NN
cord-006860-a3b8hyyr	3994	4	.	.	.
cord-006860-a3b8hyyr	3995	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	3995	2	results	result	NNS
cord-006860-a3b8hyyr	3995	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	3995	4	that	that	IN
cord-006860-a3b8hyyr	3995	5	the	the	DT
cord-006860-a3b8hyyr	3995	6	"	"	``
cord-006860-a3b8hyyr	3995	7	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	3995	8	cell	cell	NN
cord-006860-a3b8hyyr	3995	9	marker	marker	NN
cord-006860-a3b8hyyr	3995	10	"	"	''
cord-006860-a3b8hyyr	3995	11	vWF	vwf	NN
cord-006860-a3b8hyyr	3995	12	is	be	VBZ
cord-006860-a3b8hyyr	3995	13	not	not	RB
cord-006860-a3b8hyyr	3995	14	helpful	helpful	JJ
cord-006860-a3b8hyyr	3995	15	in	in	IN
cord-006860-a3b8hyyr	3995	16	predicting	predict	VBG
cord-006860-a3b8hyyr	3995	17	VOD	VOD	NNP
cord-006860-a3b8hyyr	3995	18	.	.	.
cord-006860-a3b8hyyr	3996	1	The	the	DT
cord-006860-a3b8hyyr	3996	2	kinetics	kinetic	NNS
cord-006860-a3b8hyyr	3996	3	of	of	IN
cord-006860-a3b8hyyr	3996	4	the	the	DT
cord-006860-a3b8hyyr	3996	5	investigated	investigate	VBN
cord-006860-a3b8hyyr	3996	6	parameters	parameter	NNS
cord-006860-a3b8hyyr	3996	7	underline	underline	VBP
cord-006860-a3b8hyyr	3996	8	the	the	DT
cord-006860-a3b8hyyr	3996	9	significance	significance	NN
cord-006860-a3b8hyyr	3996	10	of	of	IN
cord-006860-a3b8hyyr	3996	11	PC	pc	NN
cord-006860-a3b8hyyr	3996	12	and	and	CC
cord-006860-a3b8hyyr	3996	13	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	3996	14	as	as	IN
cord-006860-a3b8hyyr	3996	15	described	describe	VBN
cord-006860-a3b8hyyr	3996	16	by	by	IN
cord-006860-a3b8hyyr	3996	17	others	other	NNS
cord-006860-a3b8hyyr	3996	18	and	and	CC
cord-006860-a3b8hyyr	3996	19	our	-PRON-	PRP$
cord-006860-a3b8hyyr	3996	20	group	group	NN
cord-006860-a3b8hyyr	3996	21	earlier	early	RBR
cord-006860-a3b8hyyr	3996	22	,	,	,
cord-006860-a3b8hyyr	3996	23	whereas	whereas	IN
cord-006860-a3b8hyyr	3996	24	PS	PS	NNP
cord-006860-a3b8hyyr	3996	25	does	do	VBZ
cord-006860-a3b8hyyr	3996	26	not	not	RB
cord-006860-a3b8hyyr	3996	27	seem	seem	VB
cord-006860-a3b8hyyr	3996	28	to	to	TO
cord-006860-a3b8hyyr	3996	29	play	play	VB
cord-006860-a3b8hyyr	3996	30	a	a	DT
cord-006860-a3b8hyyr	3996	31	role	role	NN
cord-006860-a3b8hyyr	3996	32	in	in	IN
cord-006860-a3b8hyyr	3996	33	the	the	DT
cord-006860-a3b8hyyr	3996	34	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	3996	35	of	of	IN
cord-006860-a3b8hyyr	3996	36	VOD	VOD	NNP
cord-006860-a3b8hyyr	3996	37	.	.	.
cord-006860-a3b8hyyr	3997	1	The	the	DT
cord-006860-a3b8hyyr	3997	2	Budd	Budd	NNP
cord-006860-a3b8hyyr	3997	3	-	-	HYPH
cord-006860-a3b8hyyr	3997	4	Chiari	Chiari	NNP
cord-006860-a3b8hyyr	3997	5	syndrome	syndrome	NN
cord-006860-a3b8hyyr	3997	6	(	(	-LRB-
cord-006860-a3b8hyyr	3997	7	BCS	BCS	NNP
cord-006860-a3b8hyyr	3997	8	)	)	-RRB-
cord-006860-a3b8hyyr	3997	9	is	be	VBZ
cord-006860-a3b8hyyr	3997	10	characterized	characterize	VBN
cord-006860-a3b8hyyr	3997	11	by	by	IN
cord-006860-a3b8hyyr	3997	12	hepatic	hepatic	JJ
cord-006860-a3b8hyyr	3997	13	venous	venous	JJ
cord-006860-a3b8hyyr	3997	14	outflow	outflow	JJ
cord-006860-a3b8hyyr	3997	15	obstruction	obstruction	NN
cord-006860-a3b8hyyr	3997	16	that	that	WDT
cord-006860-a3b8hyyr	3997	17	may	may	MD
cord-006860-a3b8hyyr	3997	18	be	be	VB
cord-006860-a3b8hyyr	3997	19	caused	cause	VBN
cord-006860-a3b8hyyr	3997	20	by	by	IN
cord-006860-a3b8hyyr	3997	21	the	the	DT
cord-006860-a3b8hyyr	3997	22	precipitation	precipitation	NN
cord-006860-a3b8hyyr	3997	23	of	of	IN
cord-006860-a3b8hyyr	3997	24	a	a	DT
cord-006860-a3b8hyyr	3997	25	thrombus	thrombus	NN
cord-006860-a3b8hyyr	3997	26	.	.	.
cord-006860-a3b8hyyr	3998	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	3998	2	frequently	frequently	RB
cord-006860-a3b8hyyr	3998	3	coseggregates	coseggregate	VBZ
cord-006860-a3b8hyyr	3998	4	with	with	IN
cord-006860-a3b8hyyr	3998	5	other	other	JJ
cord-006860-a3b8hyyr	3998	6	major	major	JJ
cord-006860-a3b8hyyr	3998	7	diseases	disease	NNS
cord-006860-a3b8hyyr	3998	8	like	like	IN
cord-006860-a3b8hyyr	3998	9	myoloproliferative	myoloproliferative	JJ
cord-006860-a3b8hyyr	3998	10	diseases	disease	NNS
cord-006860-a3b8hyyr	3998	11	or	or	CC
cord-006860-a3b8hyyr	3998	12	defects	defect	NNS
cord-006860-a3b8hyyr	3998	13	in	in	IN
cord-006860-a3b8hyyr	3998	14	the	the	DT
cord-006860-a3b8hyyr	3998	15	haemostatic	haemostatic	JJ
cord-006860-a3b8hyyr	3998	16	system	system	NN
cord-006860-a3b8hyyr	3999	1	(	(	-LRB-
cord-006860-a3b8hyyr	3999	2	antiprotein	antiprotein	NNP
cord-006860-a3b8hyyr	3999	3	C	C	NNP
cord-006860-a3b8hyyr	3999	4	and	and	CC
cord-006860-a3b8hyyr	3999	5	protein	protein	NNP
cord-006860-a3b8hyyr	3999	6	S	S	NNP
cord-006860-a3b8hyyr	3999	7	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	3999	8	e.g.	e.g.	RB
cord-006860-a3b8hyyr	3999	9	)	)	-RRB-
cord-006860-a3b8hyyr	3999	10	.	.	.
cord-006860-a3b8hyyr	4000	1	Only	only	RB
cord-006860-a3b8hyyr	4000	2	recently	recently	RB
cord-006860-a3b8hyyr	4000	3	,	,	,
cord-006860-a3b8hyyr	4000	4	the	the	DT
cord-006860-a3b8hyyr	4000	5	factor	factor	NN
cord-006860-a3b8hyyr	4000	6	V	V	NNP
cord-006860-a3b8hyyr	4000	7	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	4000	8	mutation	mutation	NN
cord-006860-a3b8hyyr	4000	9	(	(	-LRB-
cord-006860-a3b8hyyr	4000	10	FVLM	FVLM	NNP
cord-006860-a3b8hyyr	4000	11	)	)	-RRB-
cord-006860-a3b8hyyr	4000	12	has	have	VBZ
cord-006860-a3b8hyyr	4000	13	also	also	RB
cord-006860-a3b8hyyr	4000	14	been	be	VBN
cord-006860-a3b8hyyr	4000	15	associated	associate	VBN
cord-006860-a3b8hyyr	4000	16	with	with	IN
cord-006860-a3b8hyyr	4000	17	BCS	BCS	NNP
cord-006860-a3b8hyyr	4000	18	.	.	.
cord-006860-a3b8hyyr	4001	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4001	2	hypothesized	hypothesize	VBD
cord-006860-a3b8hyyr	4001	3	that	that	IN
cord-006860-a3b8hyyr	4001	4	defects	defect	NNS
cord-006860-a3b8hyyr	4001	5	in	in	IN
cord-006860-a3b8hyyr	4001	6	the	the	DT
cord-006860-a3b8hyyr	4001	7	thrombo	thrombo	NN
cord-006860-a3b8hyyr	4001	8	-	-	HYPH
cord-006860-a3b8hyyr	4001	9	modelling	modelling	NN
cord-006860-a3b8hyyr	4001	10	associated	associate	VBN
cord-006860-a3b8hyyr	4001	11	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	4001	12	pathways	pathway	NNS
cord-006860-a3b8hyyr	4001	13	(	(	-LRB-
cord-006860-a3b8hyyr	4001	14	TMAAP	TMAAP	NNP
cord-006860-a3b8hyyr	4001	15	)	)	-RRB-
cord-006860-a3b8hyyr	4001	16	are	be	VBP
cord-006860-a3b8hyyr	4001	17	a	a	DT
cord-006860-a3b8hyyr	4001	18	major	major	JJ
cord-006860-a3b8hyyr	4001	19	risk	risk	NN
cord-006860-a3b8hyyr	4001	20	factor	factor	NN
cord-006860-a3b8hyyr	4001	21	for	for	IN
cord-006860-a3b8hyyr	4001	22	the	the	DT
cord-006860-a3b8hyyr	4001	23	precipitation	precipitation	NN
cord-006860-a3b8hyyr	4001	24	of	of	IN
cord-006860-a3b8hyyr	4001	25	BCS	BCS	NNP
cord-006860-a3b8hyyr	4001	26	.	.	.
cord-006860-a3b8hyyr	4002	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4002	2	screened	screen	VBD
cord-006860-a3b8hyyr	4002	3	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4002	4	cohort	cohort	NN
cord-006860-a3b8hyyr	4002	5	of	of	IN
cord-006860-a3b8hyyr	4002	6	27	27	CD
cord-006860-a3b8hyyr	4002	7	patients	patient	NNS
cord-006860-a3b8hyyr	4002	8	(	(	-LRB-
cord-006860-a3b8hyyr	4002	9	pts	pt	NNS
cord-006860-a3b8hyyr	4002	10	)	)	-RRB-
cord-006860-a3b8hyyr	4002	11	with	with	IN
cord-006860-a3b8hyyr	4002	12	BCS	BCS	NNP
cord-006860-a3b8hyyr	4002	13	for	for	IN
cord-006860-a3b8hyyr	4002	14	the	the	DT
cord-006860-a3b8hyyr	4002	15	presence	presence	NN
cord-006860-a3b8hyyr	4002	16	of	of	IN
cord-006860-a3b8hyyr	4002	17	defects	defect	NNS
cord-006860-a3b8hyyr	4002	18	in	in	IN
cord-006860-a3b8hyyr	4002	19	the	the	DT
cord-006860-a3b8hyyr	4002	20	TMAAP	TMAAP	NNP
cord-006860-a3b8hyyr	4002	21	and	and	CC
cord-006860-a3b8hyyr	4002	22	identified	identify	VBD
cord-006860-a3b8hyyr	4002	23	3	3	CD
cord-006860-a3b8hyyr	4002	24	pts	pt	NNS
cord-006860-a3b8hyyr	4002	25	with	with	IN
cord-006860-a3b8hyyr	4002	26	protein	protein	NN
cord-006860-a3b8hyyr	4002	27	S	S	NNP
cord-006860-a3b8hyyr	4002	28	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4002	29	(	(	-LRB-
cord-006860-a3b8hyyr	4002	30	PSD	PSD	NNP
cord-006860-a3b8hyyr	4002	31	)	)	-RRB-
cord-006860-a3b8hyyr	4002	32	.	.	.
cord-006860-a3b8hyyr	4003	1	These	these	DT
cord-006860-a3b8hyyr	4003	2	pts	pt	NNS
cord-006860-a3b8hyyr	4003	3	were	be	VBD
cord-006860-a3b8hyyr	4003	4	screened	screen	VBN
cord-006860-a3b8hyyr	4003	5	for	for	IN
cord-006860-a3b8hyyr	4003	6	the	the	DT
cord-006860-a3b8hyyr	4003	7	three	three	CD
cord-006860-a3b8hyyr	4003	8	point	point	NN
cord-006860-a3b8hyyr	4003	9	mutations	mutation	NNS
cord-006860-a3b8hyyr	4003	10	in	in	IN
cord-006860-a3b8hyyr	4003	11	Exon	Exon	NNP
cord-006860-a3b8hyyr	4003	12	1	1	CD
cord-006860-a3b8hyyr	4003	13	(	(	-LRB-
cord-006860-a3b8hyyr	4003	14	Codon-25	Codon-25	NNP
cord-006860-a3b8hyyr	4003	15	;	;	:
cord-006860-a3b8hyyr	4003	16	ins	ins	NNP
cord-006860-a3b8hyyr	4003	17	T	T	NNP
cord-006860-a3b8hyyr	4003	18	)	)	-RRB-
cord-006860-a3b8hyyr	4003	19	,	,	,
cord-006860-a3b8hyyr	4003	20	Exon	Exon	NNP
cord-006860-a3b8hyyr	4003	21	15	15	CD
cord-006860-a3b8hyyr	4003	22	(	(	-LRB-
cord-006860-a3b8hyyr	4003	23	Codon	Codon	NNP
cord-006860-a3b8hyyr	4003	24	636	636	CD
cord-006860-a3b8hyyr	4003	25	;	;	:
cord-006860-a3b8hyyr	4003	26	A-->T	a-->t	ADD
cord-006860-a3b8hyyr	4003	27	)	)	-RRB-
cord-006860-a3b8hyyr	4003	28	and	and	CC
cord-006860-a3b8hyyr	4003	29	in	in	IN
cord-006860-a3b8hyyr	4003	30	Intron	Intron	NNP
cord-006860-a3b8hyyr	4003	31	10	10	CD
cord-006860-a3b8hyyr	4003	32	(	(	-LRB-
cord-006860-a3b8hyyr	4003	33	G-->A	G-->A	NNP
cord-006860-a3b8hyyr	4003	34	+	+	SYM
cord-006860-a3b8hyyr	4003	35	5	5	CD
cord-006860-a3b8hyyr	4003	36	)	)	-RRB-
cord-006860-a3b8hyyr	4003	37	of	of	IN
cord-006860-a3b8hyyr	4003	38	the	the	DT
cord-006860-a3b8hyyr	4003	39	PS	PS	NNP
cord-006860-a3b8hyyr	4003	40	alpha	alpha	NN
cord-006860-a3b8hyyr	4003	41	-	-	HYPH
cord-006860-a3b8hyyr	4003	42	gene	gene	NN
cord-006860-a3b8hyyr	4003	43	that	that	WDT
cord-006860-a3b8hyyr	4003	44	have	have	VBP
cord-006860-a3b8hyyr	4003	45	been	be	VBN
cord-006860-a3b8hyyr	4003	46	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	4003	47	by	by	IN
cord-006860-a3b8hyyr	4003	48	Bertina	Bertina	NNP
cord-006860-a3b8hyyr	4003	49	et	et	NNP
cord-006860-a3b8hyyr	4003	50	al	al	NNP
cord-006860-a3b8hyyr	4003	51	to	to	TO
cord-006860-a3b8hyyr	4003	52	coseggregate	coseggregate	NNP
cord-006860-a3b8hyyr	4003	53	with	with	IN
cord-006860-a3b8hyyr	4003	54	PSD	PSD	NNP
cord-006860-a3b8hyyr	4003	55	.	.	.
cord-006860-a3b8hyyr	4004	1	Restriction	restriction	NN
cord-006860-a3b8hyyr	4004	2	enzyme	enzyme	NN
cord-006860-a3b8hyyr	4004	3	analysis	analysis	NN
cord-006860-a3b8hyyr	4004	4	and	and	CC
cord-006860-a3b8hyyr	4004	5	confirmation	confirmation	NN
cord-006860-a3b8hyyr	4004	6	-	-	HYPH
cord-006860-a3b8hyyr	4004	7	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	4004	8	gel	gel	NN
cord-006860-a3b8hyyr	4004	9	electrophoresis	electrophoresis	NN
cord-006860-a3b8hyyr	4004	10	for	for	IN
cord-006860-a3b8hyyr	4004	11	the	the	DT
cord-006860-a3b8hyyr	4004	12	detection	detection	NN
cord-006860-a3b8hyyr	4004	13	of	of	IN
cord-006860-a3b8hyyr	4004	14	single	single	JJ
cord-006860-a3b8hyyr	4004	15	-	-	HYPH
cord-006860-a3b8hyyr	4004	16	base	base	NN
cord-006860-a3b8hyyr	4004	17	differences	difference	NNS
cord-006860-a3b8hyyr	4004	18	in	in	IN
cord-006860-a3b8hyyr	4004	19	doublestranded	doublestranded	JJ
cord-006860-a3b8hyyr	4004	20	PCR	PCR	NNP
cord-006860-a3b8hyyr	4004	21	-	-	HYPH
cord-006860-a3b8hyyr	4004	22	products	product	NNS
cord-006860-a3b8hyyr	4004	23	were	be	VBD
cord-006860-a3b8hyyr	4004	24	employed	employ	VBN
cord-006860-a3b8hyyr	4004	25	.	.	.
cord-006860-a3b8hyyr	4005	1	All	all	DT
cord-006860-a3b8hyyr	4005	2	living	live	VBG
cord-006860-a3b8hyyr	4005	3	family	family	NN
cord-006860-a3b8hyyr	4005	4	members	member	NNS
cord-006860-a3b8hyyr	4005	5	of	of	IN
cord-006860-a3b8hyyr	4005	6	the	the	DT
cord-006860-a3b8hyyr	4005	7	indicator	indicator	NN
cord-006860-a3b8hyyr	4005	8	pts	pts	NNP
cord-006860-a3b8hyyr	4005	9	were	be	VBD
cord-006860-a3b8hyyr	4005	10	also	also	RB
cord-006860-a3b8hyyr	4005	11	screened	screen	VBN
cord-006860-a3b8hyyr	4005	12	for	for	IN
cord-006860-a3b8hyyr	4005	13	heterogeneties	heterogenetie	NNS
cord-006860-a3b8hyyr	4005	14	in	in	IN
cord-006860-a3b8hyyr	4005	15	the	the	DT
cord-006860-a3b8hyyr	4005	16	three	three	CD
cord-006860-a3b8hyyr	4005	17	point	point	NN
cord-006860-a3b8hyyr	4005	18	mutation	mutation	NN
cord-006860-a3b8hyyr	4005	19	as	as	IN
cord-006860-a3b8hyyr	4005	20	described	describe	VBN
cord-006860-a3b8hyyr	4005	21	.	.	.
cord-006860-a3b8hyyr	4006	1	No	no	DT
cord-006860-a3b8hyyr	4006	2	single	single	JJ
cord-006860-a3b8hyyr	4006	3	abnormality	abnormality	NN
cord-006860-a3b8hyyr	4006	4	in	in	IN
cord-006860-a3b8hyyr	4006	5	these	these	DT
cord-006860-a3b8hyyr	4006	6	genes	gene	NNS
cord-006860-a3b8hyyr	4006	7	despite	despite	IN
cord-006860-a3b8hyyr	4006	8	presence	presence	NN
cord-006860-a3b8hyyr	4006	9	of	of	IN
cord-006860-a3b8hyyr	4006	10	PBD	PBD	NNP
cord-006860-a3b8hyyr	4006	11	in	in	IN
cord-006860-a3b8hyyr	4006	12	those	those	DT
cord-006860-a3b8hyyr	4006	13	family	family	NN
cord-006860-a3b8hyyr	4006	14	members	member	NNS
cord-006860-a3b8hyyr	4006	15	was	be	VBD
cord-006860-a3b8hyyr	4006	16	found	find	VBN
cord-006860-a3b8hyyr	4006	17	.	.	.
cord-006860-a3b8hyyr	4007	1	In	in	IN
cord-006860-a3b8hyyr	4007	2	addition	addition	NN
cord-006860-a3b8hyyr	4007	3	,	,	,
cord-006860-a3b8hyyr	4007	4	pts	pts	NN
cord-006860-a3b8hyyr	4007	5	and	and	CC
cord-006860-a3b8hyyr	4007	6	family	family	NN
cord-006860-a3b8hyyr	4007	7	members	member	NNS
cord-006860-a3b8hyyr	4007	8	were	be	VBD
cord-006860-a3b8hyyr	4007	9	also	also	RB
cord-006860-a3b8hyyr	4007	10	screened	screen	VBN
cord-006860-a3b8hyyr	4007	11	for	for	IN
cord-006860-a3b8hyyr	4007	12	FVLM	FVLM	NNP
cord-006860-a3b8hyyr	4007	13	.	.	.
cord-006860-a3b8hyyr	4008	1	One	one	CD
cord-006860-a3b8hyyr	4008	2	pt	pt	NN
cord-006860-a3b8hyyr	4008	3	and	and	CC
cord-006860-a3b8hyyr	4008	4	two	two	CD
cord-006860-a3b8hyyr	4008	5	of	of	IN
cord-006860-a3b8hyyr	4008	6	his	-PRON-	PRP$
cord-006860-a3b8hyyr	4008	7	family	family	NN
cord-006860-a3b8hyyr	4008	8	members	member	NNS
cord-006860-a3b8hyyr	4008	9	,	,	,
cord-006860-a3b8hyyr	4008	10	in	in	IN
cord-006860-a3b8hyyr	4008	11	addition	addition	NN
cord-006860-a3b8hyyr	4008	12	to	to	IN
cord-006860-a3b8hyyr	4008	13	PSD	PSD	NNP
cord-006860-a3b8hyyr	4008	14	,	,	,
cord-006860-a3b8hyyr	4008	15	were	be	VBD
cord-006860-a3b8hyyr	4008	16	subject	subject	JJ
cord-006860-a3b8hyyr	4008	17	to	to	IN
cord-006860-a3b8hyyr	4008	18	FVLM	FVLM	NNP
cord-006860-a3b8hyyr	4008	19	.	.	.
cord-006860-a3b8hyyr	4009	1	The	the	DT
cord-006860-a3b8hyyr	4009	2	other	other	JJ
cord-006860-a3b8hyyr	4009	3	two	two	CD
cord-006860-a3b8hyyr	4009	4	lots	lot	NNS
cord-006860-a3b8hyyr	4009	5	and	and	CC
cord-006860-a3b8hyyr	4009	6	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4009	7	family	family	NN
cord-006860-a3b8hyyr	4009	8	members	member	NNS
cord-006860-a3b8hyyr	4009	9	were	be	VBD
cord-006860-a3b8hyyr	4009	10	not	not	RB
cord-006860-a3b8hyyr	4009	11	subject	subject	JJ
cord-006860-a3b8hyyr	4009	12	to	to	IN
cord-006860-a3b8hyyr	4009	13	FVLM	FVLM	NNP
cord-006860-a3b8hyyr	4009	14	.	.	.
cord-006860-a3b8hyyr	4010	1	In	in	IN
cord-006860-a3b8hyyr	4010	2	contrast	contrast	NN
cord-006860-a3b8hyyr	4010	3	to	to	IN
cord-006860-a3b8hyyr	4010	4	the	the	DT
cord-006860-a3b8hyyr	4010	5	first	first	JJ
cord-006860-a3b8hyyr	4010	6	family	family	NN
cord-006860-a3b8hyyr	4010	7	,	,	,
cord-006860-a3b8hyyr	4010	8	despite	despite	IN
cord-006860-a3b8hyyr	4010	9	PSD	PSD	NNP
cord-006860-a3b8hyyr	4010	10	,	,	,
cord-006860-a3b8hyyr	4010	11	those	those	DT
cord-006860-a3b8hyyr	4010	12	two	two	CD
cord-006860-a3b8hyyr	4010	13	pts	pt	NNS
cord-006860-a3b8hyyr	4010	14	suffered	suffer	VBD
cord-006860-a3b8hyyr	4010	15	from	from	IN
cord-006860-a3b8hyyr	4010	16	Morbus	Morbus	NNP
cord-006860-a3b8hyyr	4010	17	Crohn	Crohn	NNP
cord-006860-a3b8hyyr	4010	18	and	and	CC
cord-006860-a3b8hyyr	4010	19	acute	acute	JJ
cord-006860-a3b8hyyr	4010	20	myeloid	myeloid	NN
cord-006860-a3b8hyyr	4010	21	leukaemia	leukaemia	NN
cord-006860-a3b8hyyr	4010	22	as	as	IN
cord-006860-a3b8hyyr	4010	23	risk	risk	NN
cord-006860-a3b8hyyr	4010	24	factors	factor	NNS
cord-006860-a3b8hyyr	4010	25	for	for	IN
cord-006860-a3b8hyyr	4010	26	BCS	BCS	NNP
cord-006860-a3b8hyyr	4010	27	.	.	.
cord-006860-a3b8hyyr	4011	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4011	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	4011	3	:	:	:
cord-006860-a3b8hyyr	4011	4	PSD	PSD	NNP
cord-006860-a3b8hyyr	4011	5	is	be	VBZ
cord-006860-a3b8hyyr	4011	6	one	one	CD
cord-006860-a3b8hyyr	4011	7	major	major	JJ
cord-006860-a3b8hyyr	4011	8	risk	risk	NN
cord-006860-a3b8hyyr	4011	9	factor	factor	NN
cord-006860-a3b8hyyr	4011	10	for	for	IN
cord-006860-a3b8hyyr	4011	11	the	the	DT
cord-006860-a3b8hyyr	4011	12	precipitation	precipitation	NN
cord-006860-a3b8hyyr	4011	13	of	of	IN
cord-006860-a3b8hyyr	4011	14	BCS	BCS	NNP
cord-006860-a3b8hyyr	4011	15	.	.	.
cord-006860-a3b8hyyr	4012	1	To	to	TO
cord-006860-a3b8hyyr	4012	2	precipitate	precipitate	VB
cord-006860-a3b8hyyr	4012	3	this	this	DT
cord-006860-a3b8hyyr	4012	4	disease	disease	NN
cord-006860-a3b8hyyr	4012	5	,	,	,
cord-006860-a3b8hyyr	4012	6	one	one	CD
cord-006860-a3b8hyyr	4012	7	additional	additional	JJ
cord-006860-a3b8hyyr	4012	8	risk	risk	NN
cord-006860-a3b8hyyr	4012	9	factor	factor	NN
cord-006860-a3b8hyyr	4012	10	is	be	VBZ
cord-006860-a3b8hyyr	4012	11	required	require	VBN
cord-006860-a3b8hyyr	4012	12	.	.	.
cord-006860-a3b8hyyr	4013	1	PSD	PSD	NNP
cord-006860-a3b8hyyr	4013	2	may	may	MD
cord-006860-a3b8hyyr	4013	3	be	be	VB
cord-006860-a3b8hyyr	4013	4	caused	cause	VBN
cord-006860-a3b8hyyr	4013	5	by	by	IN
cord-006860-a3b8hyyr	4013	6	genomic	genomic	JJ
cord-006860-a3b8hyyr	4013	7	defects	defect	NNS
cord-006860-a3b8hyyr	4013	8	in	in	IN
cord-006860-a3b8hyyr	4013	9	the	the	DT
cord-006860-a3b8hyyr	4013	10	protein	protein	NN
cord-006860-a3b8hyyr	4013	11	S	S	NNP
cord-006860-a3b8hyyr	4013	12	gene	gene	NN
cord-006860-a3b8hyyr	4013	13	other	other	JJ
cord-006860-a3b8hyyr	4013	14	than	than	IN
cord-006860-a3b8hyyr	4013	15	those	those	DT
cord-006860-a3b8hyyr	4013	16	described	describe	VBN
cord-006860-a3b8hyyr	4013	17	by	by	IN
cord-006860-a3b8hyyr	4013	18	Bertina	Bertina	NNP
cord-006860-a3b8hyyr	4013	19	.	.	.
cord-006860-a3b8hyyr	4014	1	Only	only	RB
cord-006860-a3b8hyyr	4014	2	a	a	DT
cord-006860-a3b8hyyr	4014	3	few	few	JJ
cord-006860-a3b8hyyr	4014	4	publications	publication	NNS
cord-006860-a3b8hyyr	4014	5	describe	describe	VBP
cord-006860-a3b8hyyr	4014	6	a	a	DT
cord-006860-a3b8hyyr	4014	7	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	4014	8	disease	disease	NN
cord-006860-a3b8hyyr	4014	9	due	due	IN
cord-006860-a3b8hyyr	4014	10	to	to	IN
cord-006860-a3b8hyyr	4014	11	dramatically	dramatically	RB
cord-006860-a3b8hyyr	4014	12	reduced	reduce	VBN
cord-006860-a3b8hyyr	4014	13	protein	protein	NN
cord-006860-a3b8hyyr	4014	14	S	s	NN
cord-006860-a3b8hyyr	4014	15	levels	level	NNS
cord-006860-a3b8hyyr	4014	16	being	be	VBG
cord-006860-a3b8hyyr	4014	17	associated	associate	VBN
cord-006860-a3b8hyyr	4014	18	with	with	IN
cord-006860-a3b8hyyr	4014	19	viral	viral	JJ
cord-006860-a3b8hyyr	4014	20	or	or	CC
cord-006860-a3b8hyyr	4014	21	bacterial	bacterial	JJ
cord-006860-a3b8hyyr	4014	22	infections	infection	NNS
cord-006860-a3b8hyyr	4014	23	,	,	,
cord-006860-a3b8hyyr	4014	24	Autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	4014	25	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	4014	26	are	be	VBP
cord-006860-a3b8hyyr	4014	27	suspected	suspect	VBN
cord-006860-a3b8hyyr	4014	28	but	but	CC
cord-006860-a3b8hyyr	4014	29	the	the	DT
cord-006860-a3b8hyyr	4014	30	aetiopathogenesis	aetiopathogenesis	NN
cord-006860-a3b8hyyr	4014	31	is	be	VBZ
cord-006860-a3b8hyyr	4014	32	still	still	RB
cord-006860-a3b8hyyr	4014	33	under	under	IN
cord-006860-a3b8hyyr	4014	34	discussion	discussion	NN
cord-006860-a3b8hyyr	4014	35	.	.	.
cord-006860-a3b8hyyr	4015	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4015	2	report	report	VBP
cord-006860-a3b8hyyr	4015	3	on	on	IN
cord-006860-a3b8hyyr	4015	4	a	a	DT
cord-006860-a3b8hyyr	4015	5	5	5	CD
cord-006860-a3b8hyyr	4015	6	year	year	NN
cord-006860-a3b8hyyr	4015	7	old	old	JJ
cord-006860-a3b8hyyr	4015	8	boy	boy	NN
cord-006860-a3b8hyyr	4015	9	who	who	WP
cord-006860-a3b8hyyr	4015	10	developed	develop	VBD
cord-006860-a3b8hyyr	4015	11	purpura	purpura	NN
cord-006860-a3b8hyyr	4015	12	fulminans	fulminan	NNS
cord-006860-a3b8hyyr	4015	13	of	of	IN
cord-006860-a3b8hyyr	4015	14	the	the	DT
cord-006860-a3b8hyyr	4015	15	left	left	JJ
cord-006860-a3b8hyyr	4015	16	leg	leg	NN
cord-006860-a3b8hyyr	4015	17	during	during	IN
cord-006860-a3b8hyyr	4015	18	varicella	varicella	NN
cord-006860-a3b8hyyr	4015	19	infection	infection	NN
cord-006860-a3b8hyyr	4015	20	.	.	.
cord-006860-a3b8hyyr	4016	1	On	on	IN
cord-006860-a3b8hyyr	4016	2	the	the	DT
cord-006860-a3b8hyyr	4016	3	fourth	fourth	JJ
cord-006860-a3b8hyyr	4016	4	day	day	NN
cord-006860-a3b8hyyr	4016	5	of	of	IN
cord-006860-a3b8hyyr	4016	6	infection	infection	NN
cord-006860-a3b8hyyr	4016	7	the	the	DT
cord-006860-a3b8hyyr	4016	8	disease	disease	NN
cord-006860-a3b8hyyr	4016	9	started	start	VBD
cord-006860-a3b8hyyr	4016	10	with	with	IN
cord-006860-a3b8hyyr	4016	11	pain	pain	NN
cord-006860-a3b8hyyr	4016	12	and	and	CC
cord-006860-a3b8hyyr	4016	13	haemorrhagic	haemorrhagic	JJ
cord-006860-a3b8hyyr	4016	14	efflorescence	efflorescence	NN
cord-006860-a3b8hyyr	4016	15	localized	localize	VBN
cord-006860-a3b8hyyr	4016	16	at	at	IN
cord-006860-a3b8hyyr	4016	17	the	the	DT
cord-006860-a3b8hyyr	4016	18	left	left	JJ
cord-006860-a3b8hyyr	4016	19	taft	taft	NNP
cord-006860-a3b8hyyr	4016	20	.	.	.
cord-006860-a3b8hyyr	4017	1	On	on	IN
cord-006860-a3b8hyyr	4017	2	admission	admission	NN
cord-006860-a3b8hyyr	4017	3	the	the	DT
cord-006860-a3b8hyyr	4017	4	boy	boy	NN
cord-006860-a3b8hyyr	4017	5	suffered	suffer	VBD
cord-006860-a3b8hyyr	4017	6	from	from	IN
cord-006860-a3b8hyyr	4017	7	a	a	DT
cord-006860-a3b8hyyr	4017	8	purpura	purpura	NN
cord-006860-a3b8hyyr	4017	9	fulminans	fulminan	NNS
cord-006860-a3b8hyyr	4017	10	with	with	IN
cord-006860-a3b8hyyr	4017	11	central	central	JJ
cord-006860-a3b8hyyr	4017	12	necrosis	necrosis	NN
cord-006860-a3b8hyyr	4017	13	measuring	measure	VBG
cord-006860-a3b8hyyr	4017	14	15x8	15x8	CD
cord-006860-a3b8hyyr	4017	15	era	era	NN
cord-006860-a3b8hyyr	4017	16	.	.	.
cord-006860-a3b8hyyr	4018	1	Suspecting	suspect	VBG
cord-006860-a3b8hyyr	4018	2	a	a	DT
cord-006860-a3b8hyyr	4018	3	hereditary	hereditary	JJ
cord-006860-a3b8hyyr	4018	4	thrombophilic	thrombophilic	JJ
cord-006860-a3b8hyyr	4018	5	disease	disease	NN
cord-006860-a3b8hyyr	4018	6	we	-PRON-	PRP
cord-006860-a3b8hyyr	4018	7	started	start	VBD
cord-006860-a3b8hyyr	4018	8	therapy	therapy	NN
cord-006860-a3b8hyyr	4018	9	with	with	IN
cord-006860-a3b8hyyr	4018	10	protein	protein	NN
cord-006860-a3b8hyyr	4018	11	C	C	NNP
cord-006860-a3b8hyyr	4018	12	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4018	13	and	and	CC
cord-006860-a3b8hyyr	4018	14	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	4018	15	tissue	tissue	NN
cord-006860-a3b8hyyr	4018	16	type	type	NN
cord-006860-a3b8hyyr	4018	17	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4018	18	activator	activator	NN
cord-006860-a3b8hyyr	4018	19	.	.	.
cord-006860-a3b8hyyr	4019	1	The	the	DT
cord-006860-a3b8hyyr	4019	2	fellowing	fellowe	VBG
cord-006860-a3b8hyyr	4019	3	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4019	4	investigation	investigation	NN
cord-006860-a3b8hyyr	4019	5	showed	show	VBD
cord-006860-a3b8hyyr	4019	6	a	a	DT
cord-006860-a3b8hyyr	4019	7	severe	severe	JJ
cord-006860-a3b8hyyr	4019	8	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4019	9	of	of	IN
cord-006860-a3b8hyyr	4019	10	protein	protein	NN
cord-006860-a3b8hyyr	4019	11	S	S	NNP
cord-006860-a3b8hyyr	4019	12	(	(	-LRB-
cord-006860-a3b8hyyr	4019	13	total	total	JJ
cord-006860-a3b8hyyr	4019	14	protein	protein	NN
cord-006860-a3b8hyyr	4019	15	S	s	NN
cord-006860-a3b8hyyr	4019	16	-	-	HYPH
cord-006860-a3b8hyyr	4019	17	antigen	antigen	NNP
cord-006860-a3b8hyyr	4019	18	<	<	XX
cord-006860-a3b8hyyr	4019	19	5	5	CD
cord-006860-a3b8hyyr	4019	20	U	U	NNP
cord-006860-a3b8hyyr	4019	21	/	/	SYM
cord-006860-a3b8hyyr	4019	22	ml	ml	XX
cord-006860-a3b8hyyr	4019	23	,	,	,
cord-006860-a3b8hyyr	4019	24	free	free	JJ
cord-006860-a3b8hyyr	4019	25	antigen	antigen	NN
cord-006860-a3b8hyyr	4019	26	not	not	RB
cord-006860-a3b8hyyr	4019	27	measurable	measurable	JJ
cord-006860-a3b8hyyr	4019	28	)	)	-RRB-
cord-006860-a3b8hyyr	4019	29	in	in	IN
cord-006860-a3b8hyyr	4019	30	combination	combination	NN
cord-006860-a3b8hyyr	4019	31	with	with	IN
cord-006860-a3b8hyyr	4019	32	Factor	Factor	NNP
cord-006860-a3b8hyyr	4019	33	V	V	NNP
cord-006860-a3b8hyyr	4019	34	Leiden	Leiden	NNP
cord-006860-a3b8hyyr	4019	35	mutation	mutation	NN
cord-006860-a3b8hyyr	4019	36	.	.	.
cord-006860-a3b8hyyr	4020	1	Other	other	JJ
cord-006860-a3b8hyyr	4020	2	thrombophilie	thrombophilie	NN
cord-006860-a3b8hyyr	4020	3	and	and	CC
cord-006860-a3b8hyyr	4020	4	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4020	5	parameters	parameter	NNS
cord-006860-a3b8hyyr	4020	6	did	do	VBD
cord-006860-a3b8hyyr	4020	7	not	not	RB
cord-006860-a3b8hyyr	4020	8	show	show	VB
cord-006860-a3b8hyyr	4020	9	deviation	deviation	NN
cord-006860-a3b8hyyr	4020	10	from	from	IN
cord-006860-a3b8hyyr	4020	11	normal	normal	JJ
cord-006860-a3b8hyyr	4020	12	range	range	NN
cord-006860-a3b8hyyr	4020	13	.	.	.
cord-006860-a3b8hyyr	4021	1	After	after	IN
cord-006860-a3b8hyyr	4021	2	4	4	CD
cord-006860-a3b8hyyr	4021	3	weeks	week	NNS
cord-006860-a3b8hyyr	4021	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	4021	5	saw	see	VBD
cord-006860-a3b8hyyr	4021	6	a	a	DT
cord-006860-a3b8hyyr	4021	7	slight	slight	JJ
cord-006860-a3b8hyyr	4021	8	improvement	improvement	NN
cord-006860-a3b8hyyr	4021	9	of	of	IN
cord-006860-a3b8hyyr	4021	10	the	the	DT
cord-006860-a3b8hyyr	4021	11	total	total	JJ
cord-006860-a3b8hyyr	4021	12	protein	protein	NN
cord-006860-a3b8hyyr	4021	13	S	S	NNP
cord-006860-a3b8hyyr	4021	14	antigen	antigen	NN
cord-006860-a3b8hyyr	4021	15	up	up	IN
cord-006860-a3b8hyyr	4021	16	to	to	TO
cord-006860-a3b8hyyr	4021	17	50	50	CD
cord-006860-a3b8hyyr	4021	18	U	u	NN
cord-006860-a3b8hyyr	4021	19	/	/	SYM
cord-006860-a3b8hyyr	4021	20	ml	ml	NN
cord-006860-a3b8hyyr	4021	21	.	.	.
cord-006860-a3b8hyyr	4022	1	The	the	DT
cord-006860-a3b8hyyr	4022	2	free	free	JJ
cord-006860-a3b8hyyr	4022	3	protein	protein	NN
cord-006860-a3b8hyyr	4022	4	S	S	NNP
cord-006860-a3b8hyyr	4022	5	antigen	antigen	NN
cord-006860-a3b8hyyr	4022	6	was	be	VBD
cord-006860-a3b8hyyr	4022	7	still	still	RB
cord-006860-a3b8hyyr	4022	8	undetectable	undetectable	JJ
cord-006860-a3b8hyyr	4022	9	.	.	.
cord-006860-a3b8hyyr	4023	1	During	during	IN
cord-006860-a3b8hyyr	4023	2	the	the	DT
cord-006860-a3b8hyyr	4023	3	following	follow	VBG
cord-006860-a3b8hyyr	4023	4	weeks	week	NNS
cord-006860-a3b8hyyr	4023	5	the	the	DT
cord-006860-a3b8hyyr	4023	6	patient	patient	NN
cord-006860-a3b8hyyr	4023	7	recovered	recover	VBD
cord-006860-a3b8hyyr	4023	8	slowly	slowly	RB
cord-006860-a3b8hyyr	4023	9	and	and	CC
cord-006860-a3b8hyyr	4023	10	the	the	DT
cord-006860-a3b8hyyr	4023	11	protein	protein	NN
cord-006860-a3b8hyyr	4023	12	S	S	NNP
cord-006860-a3b8hyyr	4023	13	activity	activity	NN
cord-006860-a3b8hyyr	4023	14	and	and	CC
cord-006860-a3b8hyyr	4023	15	antigen	antigen	NN
cord-006860-a3b8hyyr	4023	16	normalized	normalize	VBN
cord-006860-a3b8hyyr	4023	17	.	.	.
cord-006860-a3b8hyyr	4024	1	Because	because	IN
cord-006860-a3b8hyyr	4024	2	of	of	IN
cord-006860-a3b8hyyr	4024	3	skin	skin	NN
cord-006860-a3b8hyyr	4024	4	necrosis	necrosis	NN
cord-006860-a3b8hyyr	4024	5	thromboembolie	thromboembolie	NNP
cord-006860-a3b8hyyr	4024	6	prophylaxis	prophylaxis	NNP
cord-006860-a3b8hyyr	4024	7	was	be	VBD
cord-006860-a3b8hyyr	4024	8	initiated	initiate	VBN
cord-006860-a3b8hyyr	4024	9	with	with	IN
cord-006860-a3b8hyyr	4024	10	low	low	JJ
cord-006860-a3b8hyyr	4024	11	molecular	molecular	JJ
cord-006860-a3b8hyyr	4024	12	weight	weight	NN
cord-006860-a3b8hyyr	4024	13	heparin	heparin	JJ
cord-006860-a3b8hyyr	4025	1	(	(	-LRB-
cord-006860-a3b8hyyr	4025	2	Fragmin	Fragmin	NNP
cord-006860-a3b8hyyr	4025	3	®	®	NNP
cord-006860-a3b8hyyr	4025	4	,	,	,
cord-006860-a3b8hyyr	4025	5	100	100	CD
cord-006860-a3b8hyyr	4025	6	IE	IE	NNP
cord-006860-a3b8hyyr	4025	7	/	/	SYM
cord-006860-a3b8hyyr	4025	8	kgbw	kgbw	NNP
cord-006860-a3b8hyyr	4025	9	/	/	SYM
cord-006860-a3b8hyyr	4025	10	die	die	VBP
cord-006860-a3b8hyyr	4025	11	)	)	-RRB-
cord-006860-a3b8hyyr	4025	12	and	and	CC
cord-006860-a3b8hyyr	4025	13	continued	continue	VBD
cord-006860-a3b8hyyr	4025	14	for	for	IN
cord-006860-a3b8hyyr	4025	15	6	6	CD
cord-006860-a3b8hyyr	4025	16	months	month	NNS
cord-006860-a3b8hyyr	4025	17	.	.	.
cord-006860-a3b8hyyr	4026	1	Under	under	IN
cord-006860-a3b8hyyr	4026	2	this	this	DT
cord-006860-a3b8hyyr	4026	3	therapy	therapy	NN
cord-006860-a3b8hyyr	4026	4	there	there	EX
cord-006860-a3b8hyyr	4026	5	were	be	VBD
cord-006860-a3b8hyyr	4026	6	no	no	DT
cord-006860-a3b8hyyr	4026	7	further	further	JJ
cord-006860-a3b8hyyr	4026	8	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	4026	9	events	event	NNS
cord-006860-a3b8hyyr	4026	10	.	.	.
cord-006860-a3b8hyyr	4027	1	These	these	DT
cord-006860-a3b8hyyr	4027	2	results	result	NNS
cord-006860-a3b8hyyr	4027	3	suggested	suggest	VBD
cord-006860-a3b8hyyr	4027	4	an	an	DT
cord-006860-a3b8hyyr	4027	5	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	4027	6	protein	protein	NN
cord-006860-a3b8hyyr	4027	7	S	S	NNP
cord-006860-a3b8hyyr	4027	8	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4027	9	in	in	IN
cord-006860-a3b8hyyr	4027	10	a	a	DT
cord-006860-a3b8hyyr	4027	11	patient	patient	NN
cord-006860-a3b8hyyr	4027	12	suffering	suffer	VBG
cord-006860-a3b8hyyr	4027	13	from	from	IN
cord-006860-a3b8hyyr	4027	14	chickenpo×.	chickenpo×.	.
cord-006860-a3b8hyyr	4028	1	An	an	DT
cord-006860-a3b8hyyr	4028	2	analyses	analysis	NNS
cord-006860-a3b8hyyr	4028	3	of	of	IN
cord-006860-a3b8hyyr	4028	4	autoantibodies	autoantibody	NNS
cord-006860-a3b8hyyr	4028	5	at	at	IN
cord-006860-a3b8hyyr	4028	6	the	the	DT
cord-006860-a3b8hyyr	4028	7	time	time	NN
cord-006860-a3b8hyyr	4028	8	of	of	IN
cord-006860-a3b8hyyr	4028	9	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	4028	10	showed	show	VBD
cord-006860-a3b8hyyr	4028	11	a	a	DT
cord-006860-a3b8hyyr	4028	12	slight	slight	JJ
cord-006860-a3b8hyyr	4028	13	increase	increase	NN
cord-006860-a3b8hyyr	4028	14	of	of	IN
cord-006860-a3b8hyyr	4028	15	the	the	DT
cord-006860-a3b8hyyr	4028	16	antieardiolipin	antieardiolipin	NNP
cord-006860-a3b8hyyr	4028	17	antibodies	antibodies	NNP
cord-006860-a3b8hyyr	4028	18	(	(	-LRB-
cord-006860-a3b8hyyr	4028	19	IgG	IgG	NNP
cord-006860-a3b8hyyr	4028	20	16,1	16,1	CD
cord-006860-a3b8hyyr	4028	21	IU	IU	NNP
cord-006860-a3b8hyyr	4028	22	/	/	SYM
cord-006860-a3b8hyyr	4028	23	ml	ml	NNP
cord-006860-a3b8hyyr	4028	24	,	,	,
cord-006860-a3b8hyyr	4028	25	IgM	IgM	NNP
cord-006860-a3b8hyyr	4028	26	15,1	15,1	CD
cord-006860-a3b8hyyr	4028	27	IU	IU	NNP
cord-006860-a3b8hyyr	4028	28	/	/	SYM
cord-006860-a3b8hyyr	4028	29	ml	ml	NN
cord-006860-a3b8hyyr	4028	30	)	)	-RRB-
cord-006860-a3b8hyyr	4028	31	which	which	WDT
cord-006860-a3b8hyyr	4028	32	normalized	normalize	VBD
cord-006860-a3b8hyyr	4028	33	during	during	IN
cord-006860-a3b8hyyr	4028	34	hospitalisation	hospitalisation	NN
cord-006860-a3b8hyyr	4028	35	.	.	.
cord-006860-a3b8hyyr	4029	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4029	2	suspect	suspect	VBP
cord-006860-a3b8hyyr	4029	3	an	an	DT
cord-006860-a3b8hyyr	4029	4	antibody	antibody	NN
cord-006860-a3b8hyyr	4029	5	to	to	TO
cord-006860-a3b8hyyr	4029	6	protein	protein	NN
cord-006860-a3b8hyyr	4029	7	S	S	NNP
cord-006860-a3b8hyyr	4029	8	probably	probably	RB
cord-006860-a3b8hyyr	4029	9	caused	cause	VBN
cord-006860-a3b8hyyr	4029	10	by	by	IN
cord-006860-a3b8hyyr	4029	11	similar	similar	JJ
cord-006860-a3b8hyyr	4029	12	presented	present	VBN
cord-006860-a3b8hyyr	4029	13	viral	viral	JJ
cord-006860-a3b8hyyr	4029	14	antigens	antigen	NNS
cord-006860-a3b8hyyr	4029	15	.	.	.
cord-006860-a3b8hyyr	4030	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4030	2	suppose	suppose	VBP
cord-006860-a3b8hyyr	4030	3	that	that	IN
cord-006860-a3b8hyyr	4030	4	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	4030	5	mechanism	mechanism	NN
cord-006860-a3b8hyyr	4030	6	during	during	IN
cord-006860-a3b8hyyr	4030	7	different	different	JJ
cord-006860-a3b8hyyr	4030	8	infections	infection	NNS
cord-006860-a3b8hyyr	4030	9	in	in	IN
cord-006860-a3b8hyyr	4030	10	combination	combination	NN
cord-006860-a3b8hyyr	4030	11	with	with	IN
cord-006860-a3b8hyyr	4030	12	a	a	DT
cord-006860-a3b8hyyr	4030	13	heterzygous	heterzygous	JJ
cord-006860-a3b8hyyr	4030	14	APC	APC	NNP
cord-006860-a3b8hyyr	4030	15	-	-	HYPH
cord-006860-a3b8hyyr	4030	16	resistance	resistance	NN
cord-006860-a3b8hyyr	4030	17	may	may	MD
cord-006860-a3b8hyyr	4030	18	be	be	VB
cord-006860-a3b8hyyr	4030	19	a	a	DT
cord-006860-a3b8hyyr	4030	20	potential	potential	JJ
cord-006860-a3b8hyyr	4030	21	risk	risk	NN
cord-006860-a3b8hyyr	4030	22	factor	factor	NN
cord-006860-a3b8hyyr	4030	23	for	for	IN
cord-006860-a3b8hyyr	4030	24	developing	develop	VBG
cord-006860-a3b8hyyr	4030	25	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	4030	26	disease	disease	NN
cord-006860-a3b8hyyr	4030	27	.	.	.
cord-006860-a3b8hyyr	4031	1	In	in	IN
cord-006860-a3b8hyyr	4031	2	the	the	DT
cord-006860-a3b8hyyr	4031	3	central	central	JJ
cord-006860-a3b8hyyr	4031	4	nervous	nervous	JJ
cord-006860-a3b8hyyr	4031	5	system	system	NN
cord-006860-a3b8hyyr	4031	6	mRNA	mrna	NN
cord-006860-a3b8hyyr	4031	7	encoding	encode	VBG
cord-006860-a3b8hyyr	4031	8	for	for	IN
cord-006860-a3b8hyyr	4031	9	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4031	10	and	and	CC
cord-006860-a3b8hyyr	4031	11	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	4031	12	receptor	receptor	NN
cord-006860-a3b8hyyr	4031	13	is	be	VBZ
cord-006860-a3b8hyyr	4031	14	present	present	JJ
cord-006860-a3b8hyyr	4031	15	and	and	CC
cord-006860-a3b8hyyr	4031	16	astroglial	astroglial	JJ
cord-006860-a3b8hyyr	4031	17	cells	cell	NNS
cord-006860-a3b8hyyr	4031	18	in	in	IN
cord-006860-a3b8hyyr	4031	19	culture	culture	NN
cord-006860-a3b8hyyr	4031	20	process	process	NN
cord-006860-a3b8hyyr	4031	21	and	and	CC
cord-006860-a3b8hyyr	4031	22	secrete	secrete	JJ
cord-006860-a3b8hyyr	4031	23	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4031	24	.	.	.
cord-006860-a3b8hyyr	4032	1	Moreover	moreover	RB
cord-006860-a3b8hyyr	4032	2	,	,	,
cord-006860-a3b8hyyr	4032	3	effects	effect	NNS
cord-006860-a3b8hyyr	4032	4	of	of	IN
cord-006860-a3b8hyyr	4032	5	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4032	6	on	on	IN
cord-006860-a3b8hyyr	4032	7	brain	brain	NN
cord-006860-a3b8hyyr	4032	8	cells	cell	NNS
cord-006860-a3b8hyyr	4032	9	including	include	VBG
cord-006860-a3b8hyyr	4032	10	change	change	NN
cord-006860-a3b8hyyr	4032	11	of	of	IN
cord-006860-a3b8hyyr	4032	12	neudte	neudte	NNP
cord-006860-a3b8hyyr	4032	13	outgrowth	outgrowth	NN
cord-006860-a3b8hyyr	4032	14	and	and	CC
cord-006860-a3b8hyyr	4032	15	astrocyte	astrocyte	JJ
cord-006860-a3b8hyyr	4032	16	shape	shape	NN
cord-006860-a3b8hyyr	4032	17	are	be	VBP
cord-006860-a3b8hyyr	4032	18	described	describe	VBN
cord-006860-a3b8hyyr	4032	19	,	,	,
cord-006860-a3b8hyyr	4032	20	but	but	CC
cord-006860-a3b8hyyr	4032	21	the	the	DT
cord-006860-a3b8hyyr	4032	22	molecular	molecular	JJ
cord-006860-a3b8hyyr	4032	23	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	4032	24	are	be	VBP
cord-006860-a3b8hyyr	4032	25	unclear	unclear	JJ
cord-006860-a3b8hyyr	4032	26	.	.	.
cord-006860-a3b8hyyr	4033	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4033	2	investigated	investigate	VBD
cord-006860-a3b8hyyr	4033	3	the	the	DT
cord-006860-a3b8hyyr	4033	4	effects	effect	NNS
cord-006860-a3b8hyyr	4033	5	of	of	IN
cord-006860-a3b8hyyr	4033	6	human	human	NN
cord-006860-a3b8hyyr	4033	7	<	<	XX
cord-006860-a3b8hyyr	4033	8	z	z	NNP
cord-006860-a3b8hyyr	4033	9	-	-	:
cord-006860-a3b8hyyr	4033	10	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4033	11	and	and	CC
cord-006860-a3b8hyyr	4033	12	a	a	DT
cord-006860-a3b8hyyr	4033	13	six	six	CD
cord-006860-a3b8hyyr	4033	14	amino	amino	NN
cord-006860-a3b8hyyr	4033	15	acid	acid	NN
cord-006860-a3b8hyyr	4033	16	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4033	17	receptor	receptor	NN
cord-006860-a3b8hyyr	4033	18	activating	activate	VBG
cord-006860-a3b8hyyr	4033	19	peptide	peptide	NN
cord-006860-a3b8hyyr	4033	20	(	(	-LRB-
cord-006860-a3b8hyyr	4033	21	TRAP-6	TRAP-6	NNP
cord-006860-a3b8hyyr	4033	22	,	,	,
cord-006860-a3b8hyyr	4033	23	SFLLRN	SFLLRN	NNP
cord-006860-a3b8hyyr	4033	24	)	)	-RRB-
cord-006860-a3b8hyyr	4033	25	on	on	IN
cord-006860-a3b8hyyr	4033	26	[	[	-LRB-
cord-006860-a3b8hyyr	4033	27	Ca2+]i	Ca2+]i	NNP
cord-006860-a3b8hyyr	4033	28	,	,	,
cord-006860-a3b8hyyr	4033	29	phosphoinositide	phosphoinositide	JJ
cord-006860-a3b8hyyr	4033	30	hydrolysis	hydrolysis	NN
cord-006860-a3b8hyyr	4033	31	and	and	CC
cord-006860-a3b8hyyr	4033	32	protein	protein	NN
cord-006860-a3b8hyyr	4033	33	kinase	kinase	NN
cord-006860-a3b8hyyr	4033	34	C	C	NNP
cord-006860-a3b8hyyr	4033	35	activation	activation	NN
cord-006860-a3b8hyyr	4033	36	in	in	IN
cord-006860-a3b8hyyr	4033	37	the	the	DT
cord-006860-a3b8hyyr	4033	38	rat	rat	NN
cord-006860-a3b8hyyr	4033	39	glioma	glioma	NN
cord-006860-a3b8hyyr	4033	40	C	C	NNP
cord-006860-a3b8hyyr	4033	41	6	6	CD
cord-006860-a3b8hyyr	4033	42	cell	cell	NN
cord-006860-a3b8hyyr	4033	43	line	line	NN
cord-006860-a3b8hyyr	4033	44	which	which	WDT
cord-006860-a3b8hyyr	4033	45	is	be	VBZ
cord-006860-a3b8hyyr	4033	46	a	a	DT
cord-006860-a3b8hyyr	4033	47	widely	widely	RB
cord-006860-a3b8hyyr	4033	48	used	use	VBN
cord-006860-a3b8hyyr	4033	49	in	in	IN
cord-006860-a3b8hyyr	4033	50	vitro	vitro	FW
cord-006860-a3b8hyyr	4033	51	model	model	NN
cord-006860-a3b8hyyr	4033	52	for	for	IN
cord-006860-a3b8hyyr	4033	53	studying	study	VBG
cord-006860-a3b8hyyr	4033	54	glial	glial	JJ
cord-006860-a3b8hyyr	4033	55	functions	function	NNS
cord-006860-a3b8hyyr	4033	56	.	.	.
cord-006860-a3b8hyyr	4034	1	Stimulation	stimulation	NN
cord-006860-a3b8hyyr	4034	2	of	of	IN
cord-006860-a3b8hyyr	4034	3	C	C	NNP
cord-006860-a3b8hyyr	4034	4	6	6	CD
cord-006860-a3b8hyyr	4034	5	cells	cell	NNS
cord-006860-a3b8hyyr	4034	6	with	with	IN
cord-006860-a3b8hyyr	4034	7	both	both	CC
cord-006860-a3b8hyyr	4034	8	c{-thrombin	c{-thrombin	NNP
cord-006860-a3b8hyyr	4034	9	and	and	CC
cord-006860-a3b8hyyr	4034	10	TRAP-6	TRAP-6	NNP
cord-006860-a3b8hyyr	4034	11	resulted	result	VBD
cord-006860-a3b8hyyr	4034	12	in	in	IN
cord-006860-a3b8hyyr	4034	13	transient	transient	JJ
cord-006860-a3b8hyyr	4034	14	[	[	-LRB-
cord-006860-a3b8hyyr	4034	15	Ca2+]i	Ca2+]i	NNP
cord-006860-a3b8hyyr	4034	16	mobilization	mobilization	NN
cord-006860-a3b8hyyr	4034	17	,	,	,
cord-006860-a3b8hyyr	4034	18	[	[	-LRB-
cord-006860-a3b8hyyr	4034	19	3H]inositol	3h]inositol	CD
cord-006860-a3b8hyyr	4034	20	phosphate	phosphate	NN
cord-006860-a3b8hyyr	4034	21	response	response	NN
cord-006860-a3b8hyyr	4034	22	and	and	CC
cord-006860-a3b8hyyr	4034	23	activation	activation	NN
cord-006860-a3b8hyyr	4034	24	of	of	IN
cord-006860-a3b8hyyr	4034	25	the	the	DT
cord-006860-a3b8hyyr	4034	26	PKC	PKC	NNP
cord-006860-a3b8hyyr	4034	27	isoenzymes	isoenzyme	NNS
cord-006860-a3b8hyyr	4034	28	c{,I],7,5	c{,I],7,5	NNP
cord-006860-a3b8hyyr	4034	29	,	,	,
cord-006860-a3b8hyyr	4034	30	and	and	CC
cord-006860-a3b8hyyr	4034	31	s.	s.	NNP
cord-006860-a3b8hyyr	4035	1	These	these	DT
cord-006860-a3b8hyyr	4035	2	results	result	NNS
cord-006860-a3b8hyyr	4035	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	4035	4	that	that	IN
cord-006860-a3b8hyyr	4035	5	~-thrombin	~-thrombin	NFP
cord-006860-a3b8hyyr	4035	6	and	and	CC
cord-006860-a3b8hyyr	4035	7	TRAP-6	TRAP-6	NNP
cord-006860-a3b8hyyr	4035	8	activate	activate	VBP
cord-006860-a3b8hyyr	4035	9	at	at	IN
cord-006860-a3b8hyyr	4035	10	least	least	JJS
cord-006860-a3b8hyyr	4035	11	partially	partially	RB
cord-006860-a3b8hyyr	4035	12	the	the	DT
cord-006860-a3b8hyyr	4035	13	same	same	JJ
cord-006860-a3b8hyyr	4035	14	intraceltular	intraceltular	NN
cord-006860-a3b8hyyr	4035	15	signaling	signal	VBG
cord-006860-a3b8hyyr	4035	16	pathways	pathway	NNS
cord-006860-a3b8hyyr	4035	17	in	in	IN
cord-006860-a3b8hyyr	4035	18	rat	rat	NN
cord-006860-a3b8hyyr	4035	19	glioma	glioma	NN
cord-006860-a3b8hyyr	4035	20	C	C	NNP
cord-006860-a3b8hyyr	4035	21	6	6	CD
cord-006860-a3b8hyyr	4035	22	cells	cell	NNS
cord-006860-a3b8hyyr	4035	23	which	which	WDT
cord-006860-a3b8hyyr	4035	24	is	be	VBZ
cord-006860-a3b8hyyr	4035	25	an	an	DT
cord-006860-a3b8hyyr	4035	26	evidence	evidence	NN
cord-006860-a3b8hyyr	4035	27	for	for	IN
cord-006860-a3b8hyyr	4035	28	involvement	involvement	NN
cord-006860-a3b8hyyr	4035	29	of	of	IN
cord-006860-a3b8hyyr	4035	30	"	"	``
cord-006860-a3b8hyyr	4035	31	tethered	tethered	JJ
cord-006860-a3b8hyyr	4035	32	ligand	ligand	NN
cord-006860-a3b8hyyr	4035	33	"	"	''
cord-006860-a3b8hyyr	4035	34	receptor	receptor	NN
cord-006860-a3b8hyyr	4035	35	in	in	IN
cord-006860-a3b8hyyr	4035	36	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4035	37	induced	induce	VBN
cord-006860-a3b8hyyr	4035	38	signaling	signal	VBG
cord-006860-a3b8hyyr	4035	39	in	in	IN
cord-006860-a3b8hyyr	4035	40	glioma	glioma	NN
cord-006860-a3b8hyyr	4035	41	C	C	NNP
cord-006860-a3b8hyyr	4035	42	6	6	CD
cord-006860-a3b8hyyr	4035	43	cells	cell	NNS
cord-006860-a3b8hyyr	4035	44	.	.	.
cord-006860-a3b8hyyr	4036	1	Further	further	JJ
cord-006860-a3b8hyyr	4036	2	investigations	investigation	NNS
cord-006860-a3b8hyyr	4036	3	in	in	IN
cord-006860-a3b8hyyr	4036	4	this	this	DT
cord-006860-a3b8hyyr	4036	5	field	field	NN
cord-006860-a3b8hyyr	4036	6	are	be	VBP
cord-006860-a3b8hyyr	4036	7	in	in	IN
cord-006860-a3b8hyyr	4036	8	progress	progress	NN
cord-006860-a3b8hyyr	4036	9	including	include	VBG
cord-006860-a3b8hyyr	4036	10	both	both	DT
cord-006860-a3b8hyyr	4036	11	receptor	receptor	NN
cord-006860-a3b8hyyr	4036	12	binding	bind	VBG
cord-006860-a3b8hyyr	4036	13	studies	study	NNS
cord-006860-a3b8hyyr	4036	14	and	and	CC
cord-006860-a3b8hyyr	4036	15	more	more	RBR
cord-006860-a3b8hyyr	4036	16	detailed	detailed	JJ
cord-006860-a3b8hyyr	4036	17	analysis	analysis	NN
cord-006860-a3b8hyyr	4036	18	of	of	IN
cord-006860-a3b8hyyr	4036	19	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	4036	20	receptor	receptor	NN
cord-006860-a3b8hyyr	4036	21	mediated	mediate	VBD
cord-006860-a3b8hyyr	4036	22	signaling	signal	VBG
cord-006860-a3b8hyyr	4036	23	network	network	NN
cord-006860-a3b8hyyr	4036	24	and	and	CC
cord-006860-a3b8hyyr	4036	25	the	the	DT
cord-006860-a3b8hyyr	4036	26	cellular	cellular	JJ
cord-006860-a3b8hyyr	4036	27	response	response	NN
cord-006860-a3b8hyyr	4036	28	of	of	IN
cord-006860-a3b8hyyr	4036	29	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4036	30	induced	induce	VBN
cord-006860-a3b8hyyr	4036	31	transmembranal	transmembranal	JJ
cord-006860-a3b8hyyr	4036	32	signal	signal	NN
cord-006860-a3b8hyyr	4036	33	transduction	transduction	NN
cord-006860-a3b8hyyr	4036	34	pathways	pathway	NNS
cord-006860-a3b8hyyr	4036	35	in	in	IN
cord-006860-a3b8hyyr	4036	36	C	C	NNP
cord-006860-a3b8hyyr	4036	37	6	6	CD
cord-006860-a3b8hyyr	4036	38	glioma	glioma	NN
cord-006860-a3b8hyyr	4036	39	.	.	.
cord-006860-a3b8hyyr	4037	1	Thrombin	Thrombin	NNP
cord-006860-a3b8hyyr	4037	2	is	be	VBZ
cord-006860-a3b8hyyr	4037	3	a	a	DT
cord-006860-a3b8hyyr	4037	4	potent	potent	JJ
cord-006860-a3b8hyyr	4037	5	mitogen	mitogen	NN
cord-006860-a3b8hyyr	4037	6	in	in	IN
cord-006860-a3b8hyyr	4037	7	vascular	vascular	JJ
cord-006860-a3b8hyyr	4037	8	smooth	smooth	JJ
cord-006860-a3b8hyyr	4037	9	muscle	muscle	NN
cord-006860-a3b8hyyr	4037	10	cells	cell	NNS
cord-006860-a3b8hyyr	4037	11	(	(	-LRB-
cord-006860-a3b8hyyr	4037	12	SMC	SMC	NNP
cord-006860-a3b8hyyr	4037	13	)	)	-RRB-
cord-006860-a3b8hyyr	4037	14	.	.	.
cord-006860-a3b8hyyr	4038	1	The	the	DT
cord-006860-a3b8hyyr	4038	2	mitogenic	mitogenic	JJ
cord-006860-a3b8hyyr	4038	3	effect	effect	NN
cord-006860-a3b8hyyr	4038	4	of	of	IN
cord-006860-a3b8hyyr	4038	5	bovine	bovine	JJ
cord-006860-a3b8hyyr	4038	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4038	7	and	and	CC
cord-006860-a3b8hyyr	4038	8	human	human	JJ
cord-006860-a3b8hyyr	4038	9	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4038	10	receptor	receptor	NN
cord-006860-a3b8hyyr	4038	11	-	-	HYPH
cord-006860-a3b8hyyr	4038	12	activating	activate	VBG
cord-006860-a3b8hyyr	4038	13	peptide	peptide	NN
cord-006860-a3b8hyyr	4038	14	(	(	-LRB-
cord-006860-a3b8hyyr	4038	15	huTRAP-14	huTRAP-14	NNP
cord-006860-a3b8hyyr	4038	16	)	)	-RRB-
cord-006860-a3b8hyyr	4038	17	was	be	VBD
cord-006860-a3b8hyyr	4038	18	investigated	investigate	VBN
cord-006860-a3b8hyyr	4038	19	in	in	IN
cord-006860-a3b8hyyr	4038	20	bovine	bovine	JJ
cord-006860-a3b8hyyr	4038	21	coronary	coronary	JJ
cord-006860-a3b8hyyr	4038	22	artery	artery	NN
cord-006860-a3b8hyyr	4038	23	smooth	smooth	JJ
cord-006860-a3b8hyyr	4038	24	muscle	muscle	NN
cord-006860-a3b8hyyr	4038	25	cells	cell	NNS
cord-006860-a3b8hyyr	4038	26	.	.	.
cord-006860-a3b8hyyr	4039	1	Confluent	confluent	NN
cord-006860-a3b8hyyr	4039	2	cells	cell	NNS
cord-006860-a3b8hyyr	4039	3	(	(	-LRB-
cord-006860-a3b8hyyr	4039	4	passage	passage	NN
cord-006860-a3b8hyyr	4039	5	4	4	CD
cord-006860-a3b8hyyr	4039	6	-	-	SYM
cord-006860-a3b8hyyr	4039	7	8	8	CD
cord-006860-a3b8hyyr	4039	8	)	)	-RRB-
cord-006860-a3b8hyyr	4039	9	were	be	VBD
cord-006860-a3b8hyyr	4039	10	incubated	incubate	VBN
cord-006860-a3b8hyyr	4039	11	for24	for24	CD
cord-006860-a3b8hyyr	4039	12	h	h	NN
cord-006860-a3b8hyyr	4039	13	in	in	IN
cord-006860-a3b8hyyr	4039	14	serum	serum	NN
cord-006860-a3b8hyyr	4039	15	-	-	HYPH
cord-006860-a3b8hyyr	4039	16	free	free	JJ
cord-006860-a3b8hyyr	4039	17	medium	medium	NN
cord-006860-a3b8hyyr	4039	18	with	with	IN
cord-006860-a3b8hyyr	4039	19	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4039	20	(	(	-LRB-
cord-006860-a3b8hyyr	4039	21	10	10	CD
cord-006860-a3b8hyyr	4039	22	nM	nm	NN
cord-006860-a3b8hyyr	4039	23	)	)	-RRB-
cord-006860-a3b8hyyr	4039	24	or	or	CC
cord-006860-a3b8hyyr	4039	25	TRAP	trap	NN
cord-006860-a3b8hyyr	4039	26	(	(	-LRB-
cord-006860-a3b8hyyr	4039	27	10	10	CD
cord-006860-a3b8hyyr	4039	28	-	-	SYM
cord-006860-a3b8hyyr	4039	29	100	100	CD
cord-006860-a3b8hyyr	4039	30	pM	pm	NN
cord-006860-a3b8hyyr	4039	31	)	)	-RRB-
cord-006860-a3b8hyyr	4039	32	.	.	.
cord-006860-a3b8hyyr	4040	1	The	the	DT
cord-006860-a3b8hyyr	4040	2	mitogenic	mitogenic	JJ
cord-006860-a3b8hyyr	4040	3	response	response	NN
cord-006860-a3b8hyyr	4040	4	was	be	VBD
cord-006860-a3b8hyyr	4040	5	assessed	assess	VBN
cord-006860-a3b8hyyr	4040	6	using	use	VBG
cord-006860-a3b8hyyr	4040	7	[	[	-LRB-
cord-006860-a3b8hyyr	4040	8	SH]thymidine	SH]thymidine	NNP
cord-006860-a3b8hyyr	4040	9	incorporation	incorporation	NN
cord-006860-a3b8hyyr	4040	10	.	.	.
cord-006860-a3b8hyyr	4041	1	Results	result	NNS
cord-006860-a3b8hyyr	4041	2	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	4041	3	that	that	IN
cord-006860-a3b8hyyr	4041	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4041	5	induced	induce	VBN
cord-006860-a3b8hyyr	4041	6	a	a	DT
cord-006860-a3b8hyyr	4041	7	three	three	CD
cord-006860-a3b8hyyr	4041	8	-	-	HYPH
cord-006860-a3b8hyyr	4041	9	to	to	IN
cord-006860-a3b8hyyr	4041	10	fourfold	fourfold	JJ
cord-006860-a3b8hyyr	4041	11	increase	increase	NN
cord-006860-a3b8hyyr	4041	12	in	in	IN
cord-006860-a3b8hyyr	4041	13	[	[	-LRB-
cord-006860-a3b8hyyr	4041	14	3H]thymidine	3h]thymidine	CD
cord-006860-a3b8hyyr	4041	15	incorporation	incorporation	NN
cord-006860-a3b8hyyr	4041	16	compared	compare	VBN
cord-006860-a3b8hyyr	4041	17	to	to	IN
cord-006860-a3b8hyyr	4041	18	the	the	DT
cord-006860-a3b8hyyr	4041	19	control	control	NN
cord-006860-a3b8hyyr	4041	20	,	,	,
cord-006860-a3b8hyyr	4041	21	thus	thus	RB
cord-006860-a3b8hyyr	4041	22	being	be	VBG
cord-006860-a3b8hyyr	4041	23	as	as	RB
cord-006860-a3b8hyyr	4041	24	active	active	JJ
cord-006860-a3b8hyyr	4041	25	as	as	IN
cord-006860-a3b8hyyr	4041	26	the	the	DT
cord-006860-a3b8hyyr	4041	27	potent	potent	JJ
cord-006860-a3b8hyyr	4041	28	mitogen	mitogen	NN
cord-006860-a3b8hyyr	4041	29	PDGF	PDGF	NNP
cord-006860-a3b8hyyr	4041	30	-	-	HYPH
cord-006860-a3b8hyyr	4041	31	BB	BB	NNP
cord-006860-a3b8hyyr	4041	32	(	(	-LRB-
cord-006860-a3b8hyyr	4041	33	20	20	CD
cord-006860-a3b8hyyr	4041	34	ng	ng	NN
cord-006860-a3b8hyyr	4041	35	/	/	SYM
cord-006860-a3b8hyyr	4041	36	ml	ml	NN
cord-006860-a3b8hyyr	4041	37	)	)	-RRB-
cord-006860-a3b8hyyr	4041	38	.	.	.
cord-006860-a3b8hyyr	4042	1	The	the	DT
cord-006860-a3b8hyyr	4042	2	mitogenic	mitogenic	JJ
cord-006860-a3b8hyyr	4042	3	effect	effect	NN
cord-006860-a3b8hyyr	4042	4	of	of	IN
cord-006860-a3b8hyyr	4042	5	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4042	6	was	be	VBD
cord-006860-a3b8hyyr	4042	7	dependent	dependent	JJ
cord-006860-a3b8hyyr	4042	8	on	on	IN
cord-006860-a3b8hyyr	4042	9	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4042	10	proteolytic	proteolytic	JJ
cord-006860-a3b8hyyr	4042	11	activity	activity	NN
cord-006860-a3b8hyyr	4042	12	.	.	.
cord-006860-a3b8hyyr	4043	1	When	when	WRB
cord-006860-a3b8hyyr	4043	2	the	the	DT
cord-006860-a3b8hyyr	4043	3	active	active	JJ
cord-006860-a3b8hyyr	4043	4	site	site	NN
cord-006860-a3b8hyyr	4043	5	of	of	IN
cord-006860-a3b8hyyr	4043	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4043	7	was	be	VBD
cord-006860-a3b8hyyr	4043	8	irreversibly	irreversibly	RB
cord-006860-a3b8hyyr	4043	9	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	4043	10	by	by	IN
cord-006860-a3b8hyyr	4043	11	D	D	NNP
cord-006860-a3b8hyyr	4043	12	-	-	HYPH
cord-006860-a3b8hyyr	4043	13	Phe	phe	NN
cord-006860-a3b8hyyr	4043	14	-	-	HYPH
cord-006860-a3b8hyyr	4043	15	Pro	pro	JJ
cord-006860-a3b8hyyr	4043	16	-	-	JJ
cord-006860-a3b8hyyr	4043	17	Arg	arg	JJ
cord-006860-a3b8hyyr	4043	18	-	-	HYPH
cord-006860-a3b8hyyr	4043	19	chloromethylketone	chloromethylketone	NN
cord-006860-a3b8hyyr	4043	20	(	(	-LRB-
cord-006860-a3b8hyyr	4043	21	PPACK	PPACK	NNP
cord-006860-a3b8hyyr	4043	22	)	)	-RRB-
cord-006860-a3b8hyyr	4044	1	no	no	DT
cord-006860-a3b8hyyr	4044	2	increase	increase	NN
cord-006860-a3b8hyyr	4044	3	in	in	IN
cord-006860-a3b8hyyr	4044	4	[	[	-LRB-
cord-006860-a3b8hyyr	4044	5	°	°	NN
cord-006860-a3b8hyyr	4045	1	H]thymidine	h]thymidine	JJ
cord-006860-a3b8hyyr	4045	2	incorporation	incorporation	NN
cord-006860-a3b8hyyr	4045	3	was	be	VBD
cord-006860-a3b8hyyr	4045	4	observed	observe	VBN
cord-006860-a3b8hyyr	4045	5	even	even	RB
cord-006860-a3b8hyyr	4045	6	at	at	IN
cord-006860-a3b8hyyr	4045	7	the	the	DT
cord-006860-a3b8hyyr	4045	8	high	high	JJ
cord-006860-a3b8hyyr	4045	9	concentration	concentration	NN
cord-006860-a3b8hyyr	4045	10	of	of	IN
cord-006860-a3b8hyyr	4045	11	250	250	CD
cord-006860-a3b8hyyr	4045	12	nM	nM	NNP
cord-006860-a3b8hyyr	4045	13	PPACKthrombin	PPACKthrombin	NNP
cord-006860-a3b8hyyr	4045	14	.	.	.
cord-006860-a3b8hyyr	4046	1	Thrombin	Thrombin	NNP
cord-006860-a3b8hyyr	4046	2	-	-	HYPH
cord-006860-a3b8hyyr	4046	3	induced	induce	VBN
cord-006860-a3b8hyyr	4046	4	[	[	-LRB-
cord-006860-a3b8hyyr	4046	5	3H]thymidine	3h]thymidine	CD
cord-006860-a3b8hyyr	4046	6	incorporation	incorporation	NN
cord-006860-a3b8hyyr	4046	7	was	be	VBD
cord-006860-a3b8hyyr	4046	8	significantly	significantly	RB
cord-006860-a3b8hyyr	4046	9	reduced	reduce	VBN
cord-006860-a3b8hyyr	4046	10	by	by	IN
cord-006860-a3b8hyyr	4046	11	the	the	DT
cord-006860-a3b8hyyr	4046	12	reversible	reversible	JJ
cord-006860-a3b8hyyr	4046	13	direct	direct	JJ
cord-006860-a3b8hyyr	4046	14	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4046	15	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4046	16	Nc£-(2naphthylsulfonylglycyl)-4-amidinophenylalanine	Nc£-(2naphthylsulfonylglycyl)-4-amidinophenylalanine	NNP
cord-006860-a3b8hyyr	4046	17	piperidide	piperidide	NN
cord-006860-a3b8hyyr	4046	18	(	(	-LRB-
cord-006860-a3b8hyyr	4046	19	NAPAP	NAPAP	NNP
cord-006860-a3b8hyyr	4046	20	,	,	,
cord-006860-a3b8hyyr	4046	21	lpM	lpM	NNP
cord-006860-a3b8hyyr	4046	22	)	)	-RRB-
cord-006860-a3b8hyyr	4046	23	.	.	.
cord-006860-a3b8hyyr	4047	1	In	in	IN
cord-006860-a3b8hyyr	4047	2	contrast	contrast	NN
cord-006860-a3b8hyyr	4047	3	to	to	IN
cord-006860-a3b8hyyr	4047	4	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4047	5	TRAP-14	TRAP-14	.
cord-006860-a3b8hyyr	4047	6	at	at	IN
cord-006860-a3b8hyyr	4047	7	a	a	DT
cord-006860-a3b8hyyr	4047	8	concentration	concentration	NN
cord-006860-a3b8hyyr	4047	9	up	up	IN
cord-006860-a3b8hyyr	4047	10	to	to	IN
cord-006860-a3b8hyyr	4047	11	100	100	CD
cord-006860-a3b8hyyr	4047	12	pM	pm	NN
cord-006860-a3b8hyyr	4047	13	did	do	VBD
cord-006860-a3b8hyyr	4047	14	not	not	RB
cord-006860-a3b8hyyr	4047	15	increase	increase	VB
cord-006860-a3b8hyyr	4047	16	[	[	-LRB-
cord-006860-a3b8hyyr	4047	17	3H]thymidine	3h]thymidine	CD
cord-006860-a3b8hyyr	4047	18	incorporation	incorporation	NN
cord-006860-a3b8hyyr	4047	19	in	in	IN
cord-006860-a3b8hyyr	4047	20	the	the	DT
cord-006860-a3b8hyyr	4047	21	absence	absence	NN
cord-006860-a3b8hyyr	4047	22	or	or	CC
cord-006860-a3b8hyyr	4047	23	presence	presence	NN
cord-006860-a3b8hyyr	4047	24	of	of	IN
cord-006860-a3b8hyyr	4047	25	the	the	DT
cord-006860-a3b8hyyr	4047	26	aminopeptidase	aminopeptidase	NN
cord-006860-a3b8hyyr	4047	27	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4047	28	amastatin	amastatin	NNP
cord-006860-a3b8hyyr	4047	29	(	(	-LRB-
cord-006860-a3b8hyyr	4047	30	10	10	CD
cord-006860-a3b8hyyr	4047	31	IJM	IJM	NNP
cord-006860-a3b8hyyr	4047	32	)	)	-RRB-
cord-006860-a3b8hyyr	4047	33	.	.	.
cord-006860-a3b8hyyr	4048	1	In	in	IN
cord-006860-a3b8hyyr	4048	2	order	order	NN
cord-006860-a3b8hyyr	4048	3	to	to	TO
cord-006860-a3b8hyyr	4048	4	demonstrate	demonstrate	VB
cord-006860-a3b8hyyr	4048	5	whether	whether	IN
cord-006860-a3b8hyyr	4048	6	huTRAP	huTRAP	NNP
cord-006860-a3b8hyyr	4048	7	caused	cause	VBD
cord-006860-a3b8hyyr	4048	8	a	a	DT
cord-006860-a3b8hyyr	4048	9	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4048	10	of	of	IN
cord-006860-a3b8hyyr	4048	11	the	the	DT
cord-006860-a3b8hyyr	4048	12	receptor	receptor	NN
cord-006860-a3b8hyyr	4048	13	and	and	CC
cord-006860-a3b8hyyr	4048	14	signal	signal	NN
cord-006860-a3b8hyyr	4048	15	transduction	transduction	NN
cord-006860-a3b8hyyr	4048	16	in	in	IN
cord-006860-a3b8hyyr	4048	17	bovine	bovine	JJ
cord-006860-a3b8hyyr	4048	18	SMC	SMC	NNP
cord-006860-a3b8hyyr	4048	19	the	the	DT
cord-006860-a3b8hyyr	4048	20	activation	activation	NN
cord-006860-a3b8hyyr	4048	21	of	of	IN
cord-006860-a3b8hyyr	4048	22	protein	protein	NN
cord-006860-a3b8hyyr	4048	23	kinase	kinase	NN
cord-006860-a3b8hyyr	4048	24	C	C	NNP
cord-006860-a3b8hyyr	4048	25	(	(	-LRB-
cord-006860-a3b8hyyr	4048	26	PKC	PKC	NNP
cord-006860-a3b8hyyr	4048	27	)	)	-RRB-
cord-006860-a3b8hyyr	4048	28	was	be	VBD
cord-006860-a3b8hyyr	4048	29	measured	measure	VBN
cord-006860-a3b8hyyr	4048	30	as	as	IN
cord-006860-a3b8hyyr	4048	31	translocation	translocation	NN
cord-006860-a3b8hyyr	4048	32	of	of	IN
cord-006860-a3b8hyyr	4048	33	the	the	DT
cord-006860-a3b8hyyr	4048	34	cytosolic	cytosolic	JJ
cord-006860-a3b8hyyr	4048	35	to	to	IN
cord-006860-a3b8hyyr	4048	36	the	the	DT
cord-006860-a3b8hyyr	4048	37	membrane	membrane	NN
cord-006860-a3b8hyyr	4048	38	bound	bind	VBN
cord-006860-a3b8hyyr	4048	39	fraction	fraction	NN
cord-006860-a3b8hyyr	4048	40	.	.	.
cord-006860-a3b8hyyr	4049	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	4049	2	was	be	VBD
cord-006860-a3b8hyyr	4049	3	found	find	VBN
cord-006860-a3b8hyyr	4049	4	that	that	IN
cord-006860-a3b8hyyr	4049	5	both	both	DT
cord-006860-a3b8hyyr	4049	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4049	7	(	(	-LRB-
cord-006860-a3b8hyyr	4049	8	10	10	CD
cord-006860-a3b8hyyr	4049	9	nM	nm	NN
cord-006860-a3b8hyyr	4049	10	)	)	-RRB-
cord-006860-a3b8hyyr	4049	11	and	and	CC
cord-006860-a3b8hyyr	4049	12	TRAP	trap	NN
cord-006860-a3b8hyyr	4049	13	(	(	-LRB-
cord-006860-a3b8hyyr	4049	14	10	10	CD
cord-006860-a3b8hyyr	4049	15	pM	pm	NN
cord-006860-a3b8hyyr	4049	16	)	)	-RRB-
cord-006860-a3b8hyyr	4049	17	induced	induce	VBD
cord-006860-a3b8hyyr	4049	18	a	a	DT
cord-006860-a3b8hyyr	4049	19	translocation	translocation	NN
cord-006860-a3b8hyyr	4049	20	of	of	IN
cord-006860-a3b8hyyr	4049	21	PKC	PKC	NNP
cord-006860-a3b8hyyr	4049	22	after	after	IN
cord-006860-a3b8hyyr	4049	23	20	20	CD
cord-006860-a3b8hyyr	4049	24	rain	rain	NN
cord-006860-a3b8hyyr	4049	25	.	.	.
cord-006860-a3b8hyyr	4050	1	In	in	IN
cord-006860-a3b8hyyr	4050	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	4050	3	,	,	,
cord-006860-a3b8hyyr	4050	4	thrembin	thrembin	NNP
cord-006860-a3b8hyyr	4050	5	and	and	CC
cord-006860-a3b8hyyr	4050	6	TRAP	TRAP	NNP
cord-006860-a3b8hyyr	4050	7	activated	activate	VBD
cord-006860-a3b8hyyr	4050	8	PKC	PKC	NNP
cord-006860-a3b8hyyr	4050	9	in	in	IN
cord-006860-a3b8hyyr	4050	10	coronary	coronary	JJ
cord-006860-a3b8hyyr	4050	11	smooth	smooth	JJ
cord-006860-a3b8hyyr	4050	12	muscle	muscle	NN
cord-006860-a3b8hyyr	4050	13	cells	cell	NNS
cord-006860-a3b8hyyr	4050	14	but	but	CC
cord-006860-a3b8hyyr	4050	15	only	only	RB
cord-006860-a3b8hyyr	4050	16	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4050	17	acted	act	VBD
cord-006860-a3b8hyyr	4050	18	as	as	IN
cord-006860-a3b8hyyr	4050	19	a	a	DT
cord-006860-a3b8hyyr	4050	20	mitogen	mitogen	NN
cord-006860-a3b8hyyr	4050	21	.	.	.
cord-006860-a3b8hyyr	4051	1	Endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4051	2	cells	cell	NNS
cord-006860-a3b8hyyr	4051	3	once	once	RB
cord-006860-a3b8hyyr	4051	4	stimulated	stimulate	VBD
cord-006860-a3b8hyyr	4051	5	with	with	IN
cord-006860-a3b8hyyr	4051	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4051	7	are	be	VBP
cord-006860-a3b8hyyr	4051	8	resistant	resistant	JJ
cord-006860-a3b8hyyr	4051	9	to	to	IN
cord-006860-a3b8hyyr	4051	10	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	4051	11	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4051	12	directly	directly	RB
cord-006860-a3b8hyyr	4051	13	after	after	IN
cord-006860-a3b8hyyr	4051	14	the	the	DT
cord-006860-a3b8hyyr	4051	15	first	first	JJ
cord-006860-a3b8hyyr	4051	16	.	.	.
cord-006860-a3b8hyyr	4052	1	But	but	CC
cord-006860-a3b8hyyr	4052	2	after	after	IN
cord-006860-a3b8hyyr	4052	3	a	a	DT
cord-006860-a3b8hyyr	4052	4	recovery	recovery	NN
cord-006860-a3b8hyyr	4052	5	period	period	NN
cord-006860-a3b8hyyr	4052	6	of	of	IN
cord-006860-a3b8hyyr	4052	7	about	about	RB
cord-006860-a3b8hyyr	4052	8	90	90	CD
cord-006860-a3b8hyyr	4052	9	min	min	NN
cord-006860-a3b8hyyr	4052	10	the	the	DT
cord-006860-a3b8hyyr	4052	11	cells	cell	NNS
cord-006860-a3b8hyyr	4052	12	are	be	VBP
cord-006860-a3b8hyyr	4052	13	sensitised	sensitise	VBN
cord-006860-a3b8hyyr	4052	14	again	again	RB
cord-006860-a3b8hyyr	4052	15	for	for	IN
cord-006860-a3b8hyyr	4052	16	activation	activation	NN
cord-006860-a3b8hyyr	4052	17	by	by	IN
cord-006860-a3b8hyyr	4052	18	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4052	19	.	.	.
cord-006860-a3b8hyyr	4053	1	In	in	IN
cord-006860-a3b8hyyr	4053	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4053	3	experiments	experiment	NNS
cord-006860-a3b8hyyr	4053	4	this	this	DT
cord-006860-a3b8hyyr	4053	5	resensitisation	resensitisation	NN
cord-006860-a3b8hyyr	4053	6	could	could	MD
cord-006860-a3b8hyyr	4053	7	n't	not	RB
cord-006860-a3b8hyyr	4053	8	be	be	VB
cord-006860-a3b8hyyr	4053	9	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	4053	10	by	by	IN
cord-006860-a3b8hyyr	4053	11	actinomycin	actinomycin	NNS
cord-006860-a3b8hyyr	4053	12	D	D	NNP
cord-006860-a3b8hyyr	4053	13	or	or	CC
cord-006860-a3b8hyyr	4053	14	cycloheximide	cycloheximide	NN
cord-006860-a3b8hyyr	4053	15	nor	nor	CC
cord-006860-a3b8hyyr	4053	16	by	by	IN
cord-006860-a3b8hyyr	4053	17	the	the	DT
cord-006860-a3b8hyyr	4053	18	phosphatase	phosphatase	NN
cord-006860-a3b8hyyr	4053	19	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4053	20	ocadaic	ocadaic	NN
cord-006860-a3b8hyyr	4053	21	acid	acid	NN
cord-006860-a3b8hyyr	4053	22	.	.	.
cord-006860-a3b8hyyr	4054	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	4054	2	an	an	DT
cord-006860-a3b8hyyr	4054	3	intracellularly	intracellularly	JJ
cord-006860-a3b8hyyr	4054	4	pool	pool	NN
cord-006860-a3b8hyyr	4054	5	of	of	IN
cord-006860-a3b8hyyr	4054	6	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	4054	7	receptors	receptor	NNS
cord-006860-a3b8hyyr	4054	8	has	have	VBZ
cord-006860-a3b8hyyr	4054	9	been	be	VBN
cord-006860-a3b8hyyr	4054	10	proposed	propose	VBN
cord-006860-a3b8hyyr	4054	11	possibly	possibly	RB
cord-006860-a3b8hyyr	4054	12	co	co	VB
cord-006860-a3b8hyyr	4054	13	-	-	JJ
cord-006860-a3b8hyyr	4054	14	localised	localised	JJ
cord-006860-a3b8hyyr	4054	15	with	with	IN
cord-006860-a3b8hyyr	4054	16	Golgi	Golgi	NNP
cord-006860-a3b8hyyr	4054	17	vesicles	vesicle	NNS
cord-006860-a3b8hyyr	4054	18	.	.	.
cord-006860-a3b8hyyr	4055	1	Brefeldin	Brefeldin	NNP
cord-006860-a3b8hyyr	4055	2	A	A	NNP
cord-006860-a3b8hyyr	4055	3	(	(	-LRB-
cord-006860-a3b8hyyr	4055	4	BFA	BFA	NNP
cord-006860-a3b8hyyr	4055	5	)	)	-RRB-
cord-006860-a3b8hyyr	4055	6	has	have	VBZ
cord-006860-a3b8hyyr	4055	7	been	be	VBN
cord-006860-a3b8hyyr	4055	8	used	use	VBN
cord-006860-a3b8hyyr	4055	9	extensively	extensively	RB
cord-006860-a3b8hyyr	4055	10	to	to	TO
cord-006860-a3b8hyyr	4055	11	investigate	investigate	VB
cord-006860-a3b8hyyr	4055	12	the	the	DT
cord-006860-a3b8hyyr	4055	13	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	4055	14	sorting	sorting	NN
cord-006860-a3b8hyyr	4055	15	of	of	IN
cord-006860-a3b8hyyr	4055	16	proteins	protein	NNS
cord-006860-a3b8hyyr	4055	17	because	because	IN
cord-006860-a3b8hyyr	4055	18	of	of	IN
cord-006860-a3b8hyyr	4055	19	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4055	20	dramatic	dramatic	JJ
cord-006860-a3b8hyyr	4055	21	alteration	alteration	NN
cord-006860-a3b8hyyr	4055	22	of	of	IN
cord-006860-a3b8hyyr	4055	23	the	the	DT
cord-006860-a3b8hyyr	4055	24	structural	structural	JJ
cord-006860-a3b8hyyr	4055	25	and	and	CC
cord-006860-a3b8hyyr	4055	26	functional	functional	JJ
cord-006860-a3b8hyyr	4055	27	organisation	organisation	NN
cord-006860-a3b8hyyr	4055	28	of	of	IN
cord-006860-a3b8hyyr	4055	29	the	the	DT
cord-006860-a3b8hyyr	4055	30	Golgi	Golgi	NNP
cord-006860-a3b8hyyr	4055	31	apparatus	apparatus	NN
cord-006860-a3b8hyyr	4055	32	.	.	.
cord-006860-a3b8hyyr	4056	1	Because	because	IN
cord-006860-a3b8hyyr	4056	2	of	of	IN
cord-006860-a3b8hyyr	4056	3	this	this	DT
cord-006860-a3b8hyyr	4056	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	4056	5	examined	examine	VBD
cord-006860-a3b8hyyr	4056	6	the	the	DT
cord-006860-a3b8hyyr	4056	7	effects	effect	NNS
cord-006860-a3b8hyyr	4056	8	of	of	IN
cord-006860-a3b8hyyr	4056	9	BFA	BFA	NNP
cord-006860-a3b8hyyr	4056	10	on	on	IN
cord-006860-a3b8hyyr	4056	11	the	the	DT
cord-006860-a3b8hyyr	4056	12	regeneration	regeneration	NN
cord-006860-a3b8hyyr	4056	13	of	of	IN
cord-006860-a3b8hyyr	4056	14	the	the	DT
cord-006860-a3b8hyyr	4056	15	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	4056	16	receptor	receptor	NN
cord-006860-a3b8hyyr	4056	17	response	response	NN
cord-006860-a3b8hyyr	4056	18	in	in	IN
cord-006860-a3b8hyyr	4056	19	human	human	JJ
cord-006860-a3b8hyyr	4056	20	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	4056	21	vein	vein	NN
cord-006860-a3b8hyyr	4056	22	and	and	CC
cord-006860-a3b8hyyr	4056	23	artery	artery	NN
cord-006860-a3b8hyyr	4056	24	cells	cell	NNS
cord-006860-a3b8hyyr	4056	25	.	.	.
cord-006860-a3b8hyyr	4057	1	The	the	DT
cord-006860-a3b8hyyr	4057	2	vWf	vWf	NNS
cord-006860-a3b8hyyr	4057	3	release	release	NN
cord-006860-a3b8hyyr	4057	4	from	from	IN
cord-006860-a3b8hyyr	4057	5	WeibeI	WeibeI	NNP
cord-006860-a3b8hyyr	4057	6	-	-	HYPH
cord-006860-a3b8hyyr	4057	7	Patade	Patade	NNP
cord-006860-a3b8hyyr	4057	8	vesicles	vesicle	NNS
cord-006860-a3b8hyyr	4057	9	was	be	VBD
cord-006860-a3b8hyyr	4057	10	used	use	VBN
cord-006860-a3b8hyyr	4057	11	as	as	IN
cord-006860-a3b8hyyr	4057	12	physiological	physiological	JJ
cord-006860-a3b8hyyr	4057	13	parameter	parameter	NN
cord-006860-a3b8hyyr	4057	14	of	of	IN
cord-006860-a3b8hyyr	4057	15	activation	activation	NN
cord-006860-a3b8hyyr	4057	16	of	of	IN
cord-006860-a3b8hyyr	4057	17	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	4057	18	receptors	receptor	NNS
cord-006860-a3b8hyyr	4057	19	by	by	IN
cord-006860-a3b8hyyr	4057	20	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4057	21	.	.	.
cord-006860-a3b8hyyr	4058	1	The	the	DT
cord-006860-a3b8hyyr	4058	2	addition	addition	NN
cord-006860-a3b8hyyr	4058	3	of	of	IN
cord-006860-a3b8hyyr	4058	4	BFA	BFA	NNP
cord-006860-a3b8hyyr	4058	5	(	(	-LRB-
cord-006860-a3b8hyyr	4058	6	20	20	CD
cord-006860-a3b8hyyr	4058	7	pg	pg	NN
cord-006860-a3b8hyyr	4058	8	/	/	SYM
cord-006860-a3b8hyyr	4058	9	ml	ml	NN
cord-006860-a3b8hyyr	4058	10	-20	-20	NNP
cord-006860-a3b8hyyr	4058	11	ng	ng	NNP
cord-006860-a3b8hyyr	4058	12	/	/	SYM
cord-006860-a3b8hyyr	4058	13	ml	ml	NN
cord-006860-a3b8hyyr	4058	14	)	)	-RRB-
cord-006860-a3b8hyyr	4058	15	to	to	IN
cord-006860-a3b8hyyr	4058	16	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4058	17	cells	cell	NNS
cord-006860-a3b8hyyr	4058	18	blocked	block	VBD
cord-006860-a3b8hyyr	4058	19	the	the	DT
cord-006860-a3b8hyyr	4058	20	receptor	receptor	NN
cord-006860-a3b8hyyr	4058	21	response	response	NN
cord-006860-a3b8hyyr	4058	22	regeneration	regeneration	NN
cord-006860-a3b8hyyr	4058	23	,	,	,
cord-006860-a3b8hyyr	4058	24	whereas	whereas	IN
cord-006860-a3b8hyyr	4058	25	the	the	DT
cord-006860-a3b8hyyr	4058	26	first	first	JJ
cord-006860-a3b8hyyr	4058	27	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4058	28	was	be	VBD
cord-006860-a3b8hyyr	4058	29	not	not	RB
cord-006860-a3b8hyyr	4058	30	influenced	influence	VBN
cord-006860-a3b8hyyr	4058	31	by	by	IN
cord-006860-a3b8hyyr	4058	32	BFA	BFA	NNP
cord-006860-a3b8hyyr	4058	33	at	at	IN
cord-006860-a3b8hyyr	4058	34	the	the	DT
cord-006860-a3b8hyyr	4058	35	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4058	36	used	use	VBN
cord-006860-a3b8hyyr	4058	37	.	.	.
cord-006860-a3b8hyyr	4059	1	These	these	DT
cord-006860-a3b8hyyr	4059	2	results	result	NNS
cord-006860-a3b8hyyr	4059	3	give	give	VBP
cord-006860-a3b8hyyr	4059	4	further	further	JJ
cord-006860-a3b8hyyr	4059	5	evidence	evidence	NN
cord-006860-a3b8hyyr	4059	6	that	that	IN
cord-006860-a3b8hyyr	4059	7	the	the	DT
cord-006860-a3b8hyyr	4059	8	proposed	propose	VBN
cord-006860-a3b8hyyr	4059	9	storage	storage	NN
cord-006860-a3b8hyyr	4059	10	pool	pool	NN
cord-006860-a3b8hyyr	4059	11	of	of	IN
cord-006860-a3b8hyyr	4059	12	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	4059	13	receptors	receptor	NNS
cord-006860-a3b8hyyr	4059	14	is	be	VBZ
cord-006860-a3b8hyyr	4059	15	Iocalised	Iocalised	NNP
cord-006860-a3b8hyyr	4059	16	in	in	IN
cord-006860-a3b8hyyr	4059	17	vesicles	vesicle	NNS
cord-006860-a3b8hyyr	4059	18	of	of	IN
cord-006860-a3b8hyyr	4059	19	the	the	DT
cord-006860-a3b8hyyr	4059	20	Golgi	Golgi	NNP
cord-006860-a3b8hyyr	4059	21	apparatus	apparatus	NN
cord-006860-a3b8hyyr	4059	22	.	.	.
cord-006860-a3b8hyyr	4060	1	Randomized	randomized	JJ
cord-006860-a3b8hyyr	4060	2	Comparison	comparison	NN
cord-006860-a3b8hyyr	4060	3	of	of	IN
cord-006860-a3b8hyyr	4060	4	Double	double	JJ
cord-006860-a3b8hyyr	4060	5	Bolus	Bolus	NNP
cord-006860-a3b8hyyr	4060	6	Reteplase	Reteplase	NNP
cord-006860-a3b8hyyr	4060	7	(	(	-LRB-
cord-006860-a3b8hyyr	4060	8	r	r	NNP
cord-006860-a3b8hyyr	4060	9	-	-	HYPH
cord-006860-a3b8hyyr	4060	10	PA	PA	NNP
cord-006860-a3b8hyyr	4060	11	)	)	-RRB-
cord-006860-a3b8hyyr	4060	12	and	and	CC
cord-006860-a3b8hyyr	4060	13	Front	Front	NNP
cord-006860-a3b8hyyr	4060	14	-	-	HYPH
cord-006860-a3b8hyyr	4060	15	Loaded	load	VBN
cord-006860-a3b8hyyr	4060	16	Alteplase	Alteplase	NNP
cord-006860-a3b8hyyr	4060	17	(	(	-LRB-
cord-006860-a3b8hyyr	4060	18	rt	rt	NNP
cord-006860-a3b8hyyr	4060	19	-	-	HYPH
cord-006860-a3b8hyyr	4060	20	PA	PA	NNP
cord-006860-a3b8hyyr	4060	21	)	)	-RRB-
cord-006860-a3b8hyyr	4060	22	in	in	IN
cord-006860-a3b8hyyr	4060	23	Patients	patient	NNS
cord-006860-a3b8hyyr	4060	24	with	with	IN
cord-006860-a3b8hyyr	4060	25	Acute	Acute	NNP
cord-006860-a3b8hyyr	4060	26	Myocardial	Myocardial	NNP
cord-006860-a3b8hyyr	4060	27	Infarction	Infarction	NNP
cord-006860-a3b8hyyr	4060	28	(	(	-LRB-
cord-006860-a3b8hyyr	4060	29	RAPID	RAPID	NNP
cord-006860-a3b8hyyr	4060	30	II	II	NNP
cord-006860-a3b8hyyr	4061	1	)	)	-RRB-
cord-006860-a3b8hyyr	4061	2	C.	C.	NNP
cord-006860-a3b8hyyr	4061	3	Bode	Bode	NNP
cord-006860-a3b8hyyr	4061	4	,	,	,
cord-006860-a3b8hyyr	4061	5	RW	RW	NNP
cord-006860-a3b8hyyr	4061	6	.	.	.
cord-006860-a3b8hyyr	4062	1	Smalling	Smalling	NNP
cord-006860-a3b8hyyr	4062	2	,	,	,
cord-006860-a3b8hyyr	4062	3	J.	J.	NNP
cord-006860-a3b8hyyr	4062	4	Kalbfleisch	Kalbfleisch	NNP
cord-006860-a3b8hyyr	4062	5	,	,	,
cord-006860-a3b8hyyr	4062	6	G.	G.	NNP
cord-006860-a3b8hyyr	4062	7	Berg	Berg	NNP
cord-006860-a3b8hyyr	4062	8	,	,	,
cord-006860-a3b8hyyr	4062	9	DJ	DJ	NNP
cord-006860-a3b8hyyr	4062	10	.	.	.
cord-006860-a3b8hyyr	4063	1	Odenheimer	Odenheimer	NNP
cord-006860-a3b8hyyr	4063	2	,	,	,
cord-006860-a3b8hyyr	4063	3	E.	E.	NNP
cord-006860-a3b8hyyr	4063	4	BShm	BShm	NNP
cord-006860-a3b8hyyr	4063	5	,	,	,
cord-006860-a3b8hyyr	4063	6	WD	WD	NNP
cord-006860-a3b8hyyr	4063	7	Weaver	Weaver	NNP
cord-006860-a3b8hyyr	4063	8	and	and	CC
cord-006860-a3b8hyyr	4063	9	the	the	DT
cord-006860-a3b8hyyr	4063	10	RAPID	RAPID	NNP
cord-006860-a3b8hyyr	4063	11	II	II	NNP
cord-006860-a3b8hyyr	4063	12	Investigators	Investigators	NNPS
cord-006860-a3b8hyyr	4063	13	.	.	.
cord-006860-a3b8hyyr	4064	1	Med	Med	NNP
cord-006860-a3b8hyyr	4064	2	.	.	.
cord-006860-a3b8hyyr	4064	3	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	4064	4	III	III	NNP
cord-006860-a3b8hyyr	4064	5	,	,	,
cord-006860-a3b8hyyr	4064	6	University	University	NNP
cord-006860-a3b8hyyr	4064	7	of	of	IN
cord-006860-a3b8hyyr	4064	8	Heidelberg	Heidelberg	NNP
cord-006860-a3b8hyyr	4064	9	,	,	,
cord-006860-a3b8hyyr	4064	10	Germany	Germany	NNP
cord-006860-a3b8hyyr	4065	1	The	the	DT
cord-006860-a3b8hyyr	4065	2	study	study	NN
cord-006860-a3b8hyyr	4065	3	was	be	VBD
cord-006860-a3b8hyyr	4065	4	undertaken	undertake	VBN
cord-006860-a3b8hyyr	4065	5	to	to	TO
cord-006860-a3b8hyyr	4065	6	assess	assess	VB
cord-006860-a3b8hyyr	4065	7	the	the	DT
cord-006860-a3b8hyyr	4065	8	efficacy	efficacy	NN
cord-006860-a3b8hyyr	4065	9	of	of	IN
cord-006860-a3b8hyyr	4065	10	a	a	DT
cord-006860-a3b8hyyr	4065	11	double	double	JJ
cord-006860-a3b8hyyr	4065	12	bolus	bolus	NN
cord-006860-a3b8hyyr	4065	13	regimen	regimen	NN
cord-006860-a3b8hyyr	4065	14	of	of	IN
cord-006860-a3b8hyyr	4065	15	10	10	CD
cord-006860-a3b8hyyr	4065	16	+	+	SYM
cord-006860-a3b8hyyr	4065	17	10	10	CD
cord-006860-a3b8hyyr	4065	18	megaunits	megaunit	NNS
cord-006860-a3b8hyyr	4065	19	of	of	IN
cord-006860-a3b8hyyr	4065	20	reteplase	reteplase	NNP
cord-006860-a3b8hyyr	4065	21	,	,	,
cord-006860-a3b8hyyr	4065	22	a	a	DT
cord-006860-a3b8hyyr	4065	23	recently	recently	RB
cord-006860-a3b8hyyr	4065	24	developed	develop	VBN
cord-006860-a3b8hyyr	4065	25	deletion	deletion	NN
cord-006860-a3b8hyyr	4065	26	mutant	mutant	NN
cord-006860-a3b8hyyr	4065	27	of	of	IN
cord-006860-a3b8hyyr	4065	28	tissue	tissue	NN
cord-006860-a3b8hyyr	4065	29	-	-	HYPH
cord-006860-a3b8hyyr	4065	30	type	type	NN
cord-006860-a3b8hyyr	4065	31	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4065	32	activator	activator	NN
cord-006860-a3b8hyyr	4065	33	,	,	,
cord-006860-a3b8hyyr	4065	34	relative	relative	JJ
cord-006860-a3b8hyyr	4065	35	to	to	IN
cord-006860-a3b8hyyr	4065	36	front	front	RB
cord-006860-a3b8hyyr	4065	37	-	-	HYPH
cord-006860-a3b8hyyr	4065	38	loaded	loaded	JJ
cord-006860-a3b8hyyr	4065	39	(	(	-LRB-
cord-006860-a3b8hyyr	4065	40	GUSTO	gusto	NN
cord-006860-a3b8hyyr	4065	41	-	-	HYPH
cord-006860-a3b8hyyr	4065	42	regimen	regimen	NN
cord-006860-a3b8hyyr	4065	43	)	)	-RRB-
cord-006860-a3b8hyyr	4065	44	alteplase	alteplase	NNP
cord-006860-a3b8hyyr	4065	45	.	.	.
cord-006860-a3b8hyyr	4066	1	There	there	EX
cord-006860-a3b8hyyr	4066	2	was	be	VBD
cord-006860-a3b8hyyr	4066	3	no	no	DT
cord-006860-a3b8hyyr	4066	4	age	age	NN
cord-006860-a3b8hyyr	4066	5	limit	limit	NN
cord-006860-a3b8hyyr	4066	6	and	and	CC
cord-006860-a3b8hyyr	4066	7	patients	patient	NNS
cord-006860-a3b8hyyr	4066	8	were	be	VBD
cord-006860-a3b8hyyr	4066	9	recruited	recruit	VBN
cord-006860-a3b8hyyr	4066	10	up	up	IN
cord-006860-a3b8hyyr	4066	11	to	to	TO
cord-006860-a3b8hyyr	4066	12	12	12	CD
cord-006860-a3b8hyyr	4066	13	hrs	hrs	NN
cord-006860-a3b8hyyr	4066	14	after	after	IN
cord-006860-a3b8hyyr	4066	15	onset	onset	NN
cord-006860-a3b8hyyr	4066	16	of	of	IN
cord-006860-a3b8hyyr	4066	17	symptoms	symptom	NNS
cord-006860-a3b8hyyr	4066	18	.	.	.
cord-006860-a3b8hyyr	4067	1	The	the	DT
cord-006860-a3b8hyyr	4067	2	primary	primary	JJ
cord-006860-a3b8hyyr	4067	3	endpoint	endpoint	NN
cord-006860-a3b8hyyr	4067	4	"	"	``
cord-006860-a3b8hyyr	4067	5	patency	patency	NN
cord-006860-a3b8hyyr	4067	6	at	at	IN
cord-006860-a3b8hyyr	4067	7	90	90	CD
cord-006860-a3b8hyyr	4067	8	minutes	minute	NNS
cord-006860-a3b8hyyr	4067	9	"	"	''
cord-006860-a3b8hyyr	4067	10	was	be	VBD
cord-006860-a3b8hyyr	4067	11	centrally	centrally	RB
cord-006860-a3b8hyyr	4067	12	assessed	assess	VBN
cord-006860-a3b8hyyr	4067	13	in	in	IN
cord-006860-a3b8hyyr	4067	14	a	a	DT
cord-006860-a3b8hyyr	4067	15	blinded	blinded	JJ
cord-006860-a3b8hyyr	4067	16	fashion	fashion	NN
cord-006860-a3b8hyyr	4067	17	.	.	.
cord-006860-a3b8hyyr	4068	1	Infarct	infarct	NN
cord-006860-a3b8hyyr	4068	2	related	relate	VBD
cord-006860-a3b8hyyr	4068	3	coronary	coronary	JJ
cord-006860-a3b8hyyr	4068	4	artery	artery	NN
cord-006860-a3b8hyyr	4068	5	patency	patency	NN
cord-006860-a3b8hyyr	4068	6	(	(	-LRB-
cord-006860-a3b8hyyr	4069	1	TIMI	TIMI	NNP
cord-006860-a3b8hyyr	4069	2	grade	grade	NN
cord-006860-a3b8hyyr	4069	3	2	2	CD
cord-006860-a3b8hyyr	4069	4	or	or	CC
cord-006860-a3b8hyyr	4069	5	3	3	CD
cord-006860-a3b8hyyr	4069	6	)	)	-RRB-
cord-006860-a3b8hyyr	4069	7	and	and	CC
cord-006860-a3b8hyyr	4069	8	complete	complete	JJ
cord-006860-a3b8hyyr	4069	9	patency	patency	NN
cord-006860-a3b8hyyr	4069	10	(	(	-LRB-
cord-006860-a3b8hyyr	4070	1	TIMI	TIMI	NNP
cord-006860-a3b8hyyr	4070	2	grade	grade	NN
cord-006860-a3b8hyyr	4070	3	3	3	CD
cord-006860-a3b8hyyr	4070	4	)	)	-RRB-
cord-006860-a3b8hyyr	4070	5	at	at	IN
cord-006860-a3b8hyyr	4070	6	90	90	CD
cord-006860-a3b8hyyr	4070	7	min	min	NN
cord-006860-a3b8hyyr	4070	8	for	for	IN
cord-006860-a3b8hyyr	4070	9	reteplase	reteplase	NNP
cord-006860-a3b8hyyr	4070	10	vs.	vs.	FW
cord-006860-a3b8hyyr	4070	11	alteplase	alteplase	NNP
cord-006860-a3b8hyyr	4070	12	were	be	VBD
cord-006860-a3b8hyyr	4070	13	83.4	83.4	CD
cord-006860-a3b8hyyr	4070	14	%	%	NN
cord-006860-a3b8hyyr	4070	15	vs.	vs.	CC
cord-006860-a3b8hyyr	4070	16	73.3	73.3	CD
cord-006860-a3b8hyyr	4070	17	%	%	NN
cord-006860-a3b8hyyr	4070	18	(	(	-LRB-
cord-006860-a3b8hyyr	4070	19	p=0.03	p=0.03	NNP
cord-006860-a3b8hyyr	4070	20	)	)	-RRB-
cord-006860-a3b8hyyr	4070	21	and	and	CC
cord-006860-a3b8hyyr	4070	22	59.9	59.9	CD
cord-006860-a3b8hyyr	4070	23	%	%	NN
cord-006860-a3b8hyyr	4070	24	vs.	vs.	IN
cord-006860-a3b8hyyr	4070	25	45.2	45.2	CD
cord-006860-a3b8hyyr	4070	26	%	%	NN
cord-006860-a3b8hyyr	4070	27	(	(	-LRB-
cord-006860-a3b8hyyr	4070	28	p=0.01	p=0.01	NNP
cord-006860-a3b8hyyr	4070	29	)	)	-RRB-
cord-006860-a3b8hyyr	4070	30	,	,	,
cord-006860-a3b8hyyr	4070	31	respectively	respectively	RB
cord-006860-a3b8hyyr	4070	32	.	.	.
cord-006860-a3b8hyyr	4071	1	At	at	IN
cord-006860-a3b8hyyr	4071	2	60	60	CD
cord-006860-a3b8hyyr	4071	3	minutes	minute	NNS
cord-006860-a3b8hyyr	4071	4	,	,	,
cord-006860-a3b8hyyr	4071	5	the	the	DT
cord-006860-a3b8hyyr	4071	6	incidence	incidence	NN
cord-006860-a3b8hyyr	4071	7	of	of	IN
cord-006860-a3b8hyyr	4071	8	both	both	DT
cord-006860-a3b8hyyr	4071	9	,	,	,
cord-006860-a3b8hyyr	4071	10	patency	patency	NN
cord-006860-a3b8hyyr	4071	11	and	and	CC
cord-006860-a3b8hyyr	4071	12	complete	complete	JJ
cord-006860-a3b8hyyr	4071	13	patency	patency	NN
cord-006860-a3b8hyyr	4071	14	was	be	VBD
cord-006860-a3b8hyyr	4071	15	also	also	RB
cord-006860-a3b8hyyr	4071	16	significantly	significantly	RB
cord-006860-a3b8hyyr	4071	17	higher	high	JJR
cord-006860-a3b8hyyr	4071	18	in	in	IN
cord-006860-a3b8hyyr	4071	19	retep	retep	NN
cord-006860-a3b8hyyr	4071	20	ase	ase	NNP
cord-006860-a3b8hyyr	4071	21	vs.	vs.	FW
cord-006860-a3b8hyyr	4071	22	aiteplase	aiteplase	NNP
cord-006860-a3b8hyyr	4071	23	treated	treat	VBD
cord-006860-a3b8hyyr	4071	24	patients	patient	NNS
cord-006860-a3b8hyyr	4071	25	:	:	:
cord-006860-a3b8hyyr	4071	26	81.8	81.8	CD
cord-006860-a3b8hyyr	4071	27	%	%	NN
cord-006860-a3b8hyyr	4071	28	vs.	vs.	CC
cord-006860-a3b8hyyr	4071	29	66.1	66.1	CD
cord-006860-a3b8hyyr	4071	30	%	%	NN
cord-006860-a3b8hyyr	4071	31	(	(	-LRB-
cord-006860-a3b8hyyr	4071	32	p=0.03	p=0.03	NN
cord-006860-a3b8hyyr	4071	33	)	)	-RRB-
cord-006860-a3b8hyyr	4071	34	.	.	.
cord-006860-a3b8hyyr	4072	1	and	and	CC
cord-006860-a3b8hyyr	4072	2	51.2	51.2	CD
cord-006860-a3b8hyyr	4072	3	%	%	NN
cord-006860-a3b8hyyr	4072	4	vs.	vs.	CC
cord-006860-a3b8hyyr	4072	5	37.4	37.4	CD
cord-006860-a3b8hyyr	4072	6	%	%	NN
cord-006860-a3b8hyyr	4072	7	(	(	-LRB-
cord-006860-a3b8hyyr	4072	8	p=0.01	p=0.01	NNP
cord-006860-a3b8hyyr	4072	9	)	)	-RRB-
cord-006860-a3b8hyyr	4072	10	.	.	.
cord-006860-a3b8hyyr	4073	1	Reteplase	Reteplase	NNP
cord-006860-a3b8hyyr	4073	2	treated	treat	VBD
cord-006860-a3b8hyyr	4073	3	patients	patient	NNS
cord-006860-a3b8hyyr	4073	4	required	require	VBD
cord-006860-a3b8hyyr	4073	5	fewer	few	JJR
cord-006860-a3b8hyyr	4073	6	additional	additional	JJ
cord-006860-a3b8hyyr	4073	7	coronary	coronary	JJ
cord-006860-a3b8hyyr	4073	8	interventions	intervention	NNS
cord-006860-a3b8hyyr	4073	9	within	within	IN
cord-006860-a3b8hyyr	4073	10	the	the	DT
cord-006860-a3b8hyyr	4073	11	first	first	JJ
cord-006860-a3b8hyyr	4073	12	6	6	CD
cord-006860-a3b8hyyr	4073	13	hrs	hrs	NN
cord-006860-a3b8hyyr	4073	14	of	of	IN
cord-006860-a3b8hyyr	4073	15	treatment	treatment	NN
cord-006860-a3b8hyyr	4073	16	(	(	-LRB-
cord-006860-a3b8hyyr	4073	17	13.3	13.3	CD
cord-006860-a3b8hyyr	4073	18	%	%	NN
cord-006860-a3b8hyyr	4073	19	vs.	vs.	CC
cord-006860-a3b8hyyr	4073	20	26.5	26.5	CD
cord-006860-a3b8hyyr	4073	21	%	%	NN
cord-006860-a3b8hyyr	4073	22	,	,	,
cord-006860-a3b8hyyr	4073	23	p=0.01	p=0.01	NNP
cord-006860-a3b8hyyr	4073	24	)	)	-RRB-
cord-006860-a3b8hyyr	4073	25	.	.	.
cord-006860-a3b8hyyr	4074	1	There	there	EX
cord-006860-a3b8hyyr	4074	2	were	be	VBD
cord-006860-a3b8hyyr	4074	3	no	no	DT
cord-006860-a3b8hyyr	4074	4	significant	significant	JJ
cord-006860-a3b8hyyr	4074	5	differences	difference	NNS
cord-006860-a3b8hyyr	4074	6	between	between	IN
cord-006860-a3b8hyyr	4074	7	reteplase	reteplase	NNP
cord-006860-a3b8hyyr	4074	8	vs.	vs.	FW
cord-006860-a3b8hyyr	4074	9	alteplase	alteplase	NNP
cord-006860-a3b8hyyr	4074	10	regimens	regimen	NNS
cord-006860-a3b8hyyr	4074	11	in	in	IN
cord-006860-a3b8hyyr	4074	12	35	35	CD
cord-006860-a3b8hyyr	4074	13	day	day	NN
cord-006860-a3b8hyyr	4074	14	mortality	mortality	NN
cord-006860-a3b8hyyr	4074	15	(	(	-LRB-
cord-006860-a3b8hyyr	4074	16	4.1	4.1	CD
cord-006860-a3b8hyyr	4074	17	%	%	NN
cord-006860-a3b8hyyr	4074	18	vs.	vs.	CC
cord-006860-a3b8hyyr	4074	19	8.4	8.4	CD
cord-006860-a3b8hyyr	4074	20	%	%	NN
cord-006860-a3b8hyyr	4074	21	)	)	-RRB-
cord-006860-a3b8hyyr	4074	22	,	,	,
cord-006860-a3b8hyyr	4074	23	severe	severe	JJ
cord-006860-a3b8hyyr	4074	24	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	4074	25	(	(	-LRB-
cord-006860-a3b8hyyr	4074	26	12.4	12.4	CD
cord-006860-a3b8hyyr	4074	27	%	%	NN
cord-006860-a3b8hyyr	4074	28	vs	vs	IN
cord-006860-a3b8hyyr	4074	29	9.7	9.7	CD
cord-006860-a3b8hyyr	4074	30	%	%	NN
cord-006860-a3b8hyyr	4074	31	)	)	-RRB-
cord-006860-a3b8hyyr	4075	1	•	•	NNP
cord-006860-a3b8hyyr	4076	1	or	or	CC
cord-006860-a3b8hyyr	4076	2	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	4076	3	stroke	stroke	NN
cord-006860-a3b8hyyr	4076	4	(	(	-LRB-
cord-006860-a3b8hyyr	4076	5	1.2	1.2	CD
cord-006860-a3b8hyyr	4076	6	%	%	NN
cord-006860-a3b8hyyr	4076	7	vs.	vs.	IN
cord-006860-a3b8hyyr	4076	8	1.8	1.8	CD
cord-006860-a3b8hyyr	4076	9	%	%	NN
cord-006860-a3b8hyyr	4076	10	)	)	-RRB-
cord-006860-a3b8hyyr	4076	11	.	.	.
cord-006860-a3b8hyyr	4077	1	Reteplase	Reteplase	NNP
cord-006860-a3b8hyyr	4077	2	,	,	,
cord-006860-a3b8hyyr	4077	3	when	when	WRB
cord-006860-a3b8hyyr	4077	4	given	give	VBN
cord-006860-a3b8hyyr	4077	5	as	as	IN
cord-006860-a3b8hyyr	4077	6	a	a	DT
cord-006860-a3b8hyyr	4077	7	double	double	JJ
cord-006860-a3b8hyyr	4077	8	bolus	bolus	NN
cord-006860-a3b8hyyr	4077	9	of	of	IN
cord-006860-a3b8hyyr	4077	10	10	10	CD
cord-006860-a3b8hyyr	4077	11	+	+	SYM
cord-006860-a3b8hyyr	4077	12	10	10	CD
cord-006860-a3b8hyyr	4077	13	MU	MU	NNS
cord-006860-a3b8hyyr	4077	14	to	to	IN
cord-006860-a3b8hyyr	4077	15	patients	patient	NNS
cord-006860-a3b8hyyr	4077	16	with	with	IN
cord-006860-a3b8hyyr	4077	17	acute	acute	JJ
cord-006860-a3b8hyyr	4077	18	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	4077	19	infarction	infarction	NN
cord-006860-a3b8hyyr	4077	20	,	,	,
cord-006860-a3b8hyyr	4077	21	achieves	achieve	VBZ
cord-006860-a3b8hyyr	4077	22	significantly	significantly	RB
cord-006860-a3b8hyyr	4077	23	higher	high	JJR
cord-006860-a3b8hyyr	4077	24	rates	rate	NNS
cord-006860-a3b8hyyr	4077	25	of	of	IN
cord-006860-a3b8hyyr	4077	26	early	early	JJ
cord-006860-a3b8hyyr	4077	27	patency	patency	NN
cord-006860-a3b8hyyr	4077	28	and	and	CC
cord-006860-a3b8hyyr	4077	29	requires	require	VBZ
cord-006860-a3b8hyyr	4077	30	fewer	few	JJR
cord-006860-a3b8hyyr	4077	31	acute	acute	JJ
cord-006860-a3b8hyyr	4077	32	coronary	coronary	JJ
cord-006860-a3b8hyyr	4077	33	interventions	intervention	NNS
cord-006860-a3b8hyyr	4077	34	than	than	IN
cord-006860-a3b8hyyr	4077	35	front	front	RB
cord-006860-a3b8hyyr	4077	36	-	-	HYPH
cord-006860-a3b8hyyr	4077	37	loaded	load	VBN
cord-006860-a3b8hyyr	4077	38	alteplase	alteplase	NN
cord-006860-a3b8hyyr	4077	39	without	without	IN
cord-006860-a3b8hyyr	4077	40	an	an	DT
cord-006860-a3b8hyyr	4077	41	apparent	apparent	JJ
cord-006860-a3b8hyyr	4077	42	increased	increase	VBN
cord-006860-a3b8hyyr	4077	43	risk	risk	NN
cord-006860-a3b8hyyr	4077	44	of	of	IN
cord-006860-a3b8hyyr	4077	45	complications	complication	NNS
cord-006860-a3b8hyyr	4077	46	.	.	.
cord-006860-a3b8hyyr	4078	1	Lysis	lysis	NN
cord-006860-a3b8hyyr	4078	2	therapy	therapy	NN
cord-006860-a3b8hyyr	4078	3	with	with	IN
cord-006860-a3b8hyyr	4078	4	UHSK	UHSK	NNP
cord-006860-a3b8hyyr	4078	5	of	of	IN
cord-006860-a3b8hyyr	4078	6	deep	deep	JJ
cord-006860-a3b8hyyr	4078	7	vein	vein	NN
cord-006860-a3b8hyyr	4078	8	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4078	9	(	(	-LRB-
cord-006860-a3b8hyyr	4078	10	DVT	DVT	NNP
cord-006860-a3b8hyyr	4078	11	)	)	-RRB-
cord-006860-a3b8hyyr	4078	12	of	of	IN
cord-006860-a3b8hyyr	4078	13	the	the	DT
cord-006860-a3b8hyyr	4078	14	lower	low	JJR
cord-006860-a3b8hyyr	4078	15	extremity	extremity	NN
cord-006860-a3b8hyyr	4078	16	commoniy	commoniy	IN
cord-006860-a3b8hyyr	4078	17	results	result	NNS
cord-006860-a3b8hyyr	4078	18	in	in	IN
cord-006860-a3b8hyyr	4078	19	a	a	DT
cord-006860-a3b8hyyr	4078	20	relatively	relatively	RB
cord-006860-a3b8hyyr	4078	21	high	high	JJ
cord-006860-a3b8hyyr	4078	22	patency	patency	NN
cord-006860-a3b8hyyr	4078	23	rate	rate	NN
cord-006860-a3b8hyyr	4078	24	.	.	.
cord-006860-a3b8hyyr	4079	1	In	in	IN
cord-006860-a3b8hyyr	4079	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4079	3	patients	patient	NNS
cord-006860-a3b8hyyr	4079	4	,	,	,
cord-006860-a3b8hyyr	4079	5	patency	patency	NNP
cord-006860-a3b8hyyr	4079	6	was	be	VBD
cord-006860-a3b8hyyr	4079	7	achieved	achieve	VBN
cord-006860-a3b8hyyr	4079	8	in	in	IN
cord-006860-a3b8hyyr	4079	9	approx	approx	NN
cord-006860-a3b8hyyr	4079	10	.	.	.
cord-006860-a3b8hyyr	4080	1	70	70	CD
cord-006860-a3b8hyyr	4080	2	-	-	SYM
cord-006860-a3b8hyyr	4080	3	80	80	CD
cord-006860-a3b8hyyr	4080	4	%	%	NN
cord-006860-a3b8hyyr	4080	5	.	.	.
cord-006860-a3b8hyyr	4081	1	These	these	DT
cord-006860-a3b8hyyr	4081	2	results	result	NNS
cord-006860-a3b8hyyr	4081	3	were	be	VBD
cord-006860-a3b8hyyr	4081	4	supported	support	VBN
cord-006860-a3b8hyyr	4081	5	by	by	IN
cord-006860-a3b8hyyr	4081	6	several	several	JJ
cord-006860-a3b8hyyr	4081	7	studies	study	NNS
cord-006860-a3b8hyyr	4081	8	.	.	.
cord-006860-a3b8hyyr	4082	1	In	in	IN
cord-006860-a3b8hyyr	4082	2	DVT	DVT	NNP
cord-006860-a3b8hyyr	4082	3	of	of	IN
cord-006860-a3b8hyyr	4082	4	the	the	DT
cord-006860-a3b8hyyr	4082	5	pelvic	pelvic	JJ
cord-006860-a3b8hyyr	4082	6	veins	vein	NNS
cord-006860-a3b8hyyr	4082	7	,	,	,
cord-006860-a3b8hyyr	4082	8	however	however	RB
cord-006860-a3b8hyyr	4082	9	,	,	,
cord-006860-a3b8hyyr	4082	10	this	this	DT
cord-006860-a3b8hyyr	4082	11	kind	kind	NN
cord-006860-a3b8hyyr	4082	12	of	of	IN
cord-006860-a3b8hyyr	4082	13	aggressive	aggressive	JJ
cord-006860-a3b8hyyr	4082	14	therapy	therapy	NN
cord-006860-a3b8hyyr	4082	15	is	be	VBZ
cord-006860-a3b8hyyr	4082	16	excluded	exclude	VBN
cord-006860-a3b8hyyr	4082	17	due	due	IN
cord-006860-a3b8hyyr	4082	18	to	to	IN
cord-006860-a3b8hyyr	4082	19	the	the	DT
cord-006860-a3b8hyyr	4082	20	risk	risk	NN
cord-006860-a3b8hyyr	4082	21	of	of	IN
cord-006860-a3b8hyyr	4082	22	iatrogenically	iatrogenically	RB
cord-006860-a3b8hyyr	4082	23	induced	induce	VBN
cord-006860-a3b8hyyr	4082	24	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	4082	25	embolism	embolism	NN
cord-006860-a3b8hyyr	4082	26	.	.	.
cord-006860-a3b8hyyr	4083	1	On	on	IN
cord-006860-a3b8hyyr	4083	2	the	the	DT
cord-006860-a3b8hyyr	4083	3	other	other	JJ
cord-006860-a3b8hyyr	4083	4	hand	hand	NN
cord-006860-a3b8hyyr	4083	5	,	,	,
cord-006860-a3b8hyyr	4083	6	the	the	DT
cord-006860-a3b8hyyr	4083	7	need	need	NN
cord-006860-a3b8hyyr	4083	8	for	for	IN
cord-006860-a3b8hyyr	4083	9	an	an	DT
cord-006860-a3b8hyyr	4083	10	effective	effective	JJ
cord-006860-a3b8hyyr	4083	11	therapy	therapy	NN
cord-006860-a3b8hyyr	4083	12	is	be	VBZ
cord-006860-a3b8hyyr	4083	13	evident	evident	JJ
cord-006860-a3b8hyyr	4083	14	because	because	IN
cord-006860-a3b8hyyr	4083	15	of	of	IN
cord-006860-a3b8hyyr	4083	16	the	the	DT
cord-006860-a3b8hyyr	4083	17	usually	usually	RB
cord-006860-a3b8hyyr	4083	18	occtnring	occtnre	VBG
cord-006860-a3b8hyyr	4083	19	complete	complete	JJ
cord-006860-a3b8hyyr	4083	20	occlusion	occlusion	NN
cord-006860-a3b8hyyr	4083	21	of	of	IN
cord-006860-a3b8hyyr	4083	22	the	the	DT
cord-006860-a3b8hyyr	4083	23	pelvic	pelvic	JJ
cord-006860-a3b8hyyr	4083	24	veins	vein	NNS
cord-006860-a3b8hyyr	4083	25	and	and	CC
cord-006860-a3b8hyyr	4083	26	the	the	DT
cord-006860-a3b8hyyr	4083	27	following	following	JJ
cord-006860-a3b8hyyr	4083	28	severe	severe	JJ
cord-006860-a3b8hyyr	4083	29	clinical	clinical	JJ
cord-006860-a3b8hyyr	4083	30	symptoms	symptom	NNS
cord-006860-a3b8hyyr	4083	31	0Phlegnmsia	0Phlegnmsia	NNP
cord-006860-a3b8hyyr	4083	32	cerulca	cerulca	NNP
cord-006860-a3b8hyyr	4083	33	dolens	dolens	NNP
cord-006860-a3b8hyyr	4083	34	etc	etc	FW
cord-006860-a3b8hyyr	4083	35	.	.	.
cord-006860-a3b8hyyr	4083	36	)	)	-RRB-
cord-006860-a3b8hyyr	4083	37	.	.	.
cord-006860-a3b8hyyr	4084	1	Until	until	IN
cord-006860-a3b8hyyr	4084	2	September	September	NNP
cord-006860-a3b8hyyr	4084	3	"	"	''
cord-006860-a3b8hyyr	4084	4	95	95	CD
cord-006860-a3b8hyyr	4084	5	,	,	,
cord-006860-a3b8hyyr	4084	6	44	44	CD
cord-006860-a3b8hyyr	4084	7	consecutive	consecutive	JJ
cord-006860-a3b8hyyr	4084	8	patients	patient	NNS
cord-006860-a3b8hyyr	4084	9	(	(	-LRB-
cord-006860-a3b8hyyr	4084	10	16	16	CD
cord-006860-a3b8hyyr	4084	11	males	male	NNS
cord-006860-a3b8hyyr	4084	12	,	,	,
cord-006860-a3b8hyyr	4084	13	mean	mean	VB
cord-006860-a3b8hyyr	4084	14	age	age	NN
cord-006860-a3b8hyyr	4084	15	41	41	CD
cord-006860-a3b8hyyr	4084	16	ranging	range	VBG
cord-006860-a3b8hyyr	4084	17	from	from	IN
cord-006860-a3b8hyyr	4084	18	18	18	CD
cord-006860-a3b8hyyr	4084	19	to	to	TO
cord-006860-a3b8hyyr	4084	20	63	63	CD
cord-006860-a3b8hyyr	4084	21	years	year	NNS
cord-006860-a3b8hyyr	4084	22	)	)	-RRB-
cord-006860-a3b8hyyr	4084	23	with	with	IN
cord-006860-a3b8hyyr	4084	24	DVT	DVT	NNP
cord-006860-a3b8hyyr	4084	25	of	of	IN
cord-006860-a3b8hyyr	4084	26	pelvic	pelvic	JJ
cord-006860-a3b8hyyr	4084	27	veins	vein	NNS
cord-006860-a3b8hyyr	4084	28	were	be	VBD
cord-006860-a3b8hyyr	4084	29	Included	include	VBN
cord-006860-a3b8hyyr	4084	30	in	in	IN
cord-006860-a3b8hyyr	4084	31	this	this	DT
cord-006860-a3b8hyyr	4084	32	study	study	NN
cord-006860-a3b8hyyr	4084	33	.	.	.
cord-006860-a3b8hyyr	4085	1	After	after	IN
cord-006860-a3b8hyyr	4085	2	clinical	clinical	JJ
cord-006860-a3b8hyyr	4085	3	and	and	CC
cord-006860-a3b8hyyr	4085	4	phiebographic	phiebographic	JJ
cord-006860-a3b8hyyr	4085	5	/	/	SYM
cord-006860-a3b8hyyr	4085	6	computer	computer	NN
cord-006860-a3b8hyyr	4085	7	tomographic	tomographic	NN
cord-006860-a3b8hyyr	4085	8	(	(	-LRB-
cord-006860-a3b8hyyr	4085	9	CT	CT	NNP
cord-006860-a3b8hyyr	4085	10	)	)	-RRB-
cord-006860-a3b8hyyr	4085	11	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	4085	12	,	,	,
cord-006860-a3b8hyyr	4085	13	a	a	DT
cord-006860-a3b8hyyr	4085	14	temporary	temporary	JJ
cord-006860-a3b8hyyr	4085	15	filter	filter	NN
cord-006860-a3b8hyyr	4085	16	system	system	NN
cord-006860-a3b8hyyr	4085	17	was	be	VBD
cord-006860-a3b8hyyr	4085	18	placed	place	VBN
cord-006860-a3b8hyyr	4085	19	intravenously	intravenously	RB
cord-006860-a3b8hyyr	4085	20	either	either	CC
cord-006860-a3b8hyyr	4085	21	by	by	IN
cord-006860-a3b8hyyr	4085	22	a	a	DT
cord-006860-a3b8hyyr	4085	23	wambmchial	wambmchial	NN
cord-006860-a3b8hyyr	4085	24	(	(	-LRB-
cord-006860-a3b8hyyr	4085	25	34	34	CD
cord-006860-a3b8hyyr	4085	26	pat	pat	NN
cord-006860-a3b8hyyr	4085	27	.	.	.
cord-006860-a3b8hyyr	4085	28	)	)	-RRB-
cord-006860-a3b8hyyr	4086	1	access	access	NNP
cord-006860-a3b8hyyr	4086	2	route	route	NN
cord-006860-a3b8hyyr	4086	3	,	,	,
cord-006860-a3b8hyyr	4086	4	lransfemorally	lransfemorally	NN
cord-006860-a3b8hyyr	4086	5	(	(	-LRB-
cord-006860-a3b8hyyr	4086	6	6	6	CD
cord-006860-a3b8hyyr	4086	7	pat	pat	NNP
cord-006860-a3b8hyyr	4086	8	_	_	NNP
cord-006860-a3b8hyyr	4086	9	)	)	-RRB-
cord-006860-a3b8hyyr	4086	10	or	or	CC
cord-006860-a3b8hyyr	4086	11	Wansjngularly	Wansjngularly	NNP
cord-006860-a3b8hyyr	4086	12	(	(	-LRB-
cord-006860-a3b8hyyr	4086	13	4	4	CD
cord-006860-a3b8hyyr	4086	14	pat	pat	NN
cord-006860-a3b8hyyr	4086	15	.	.	.
cord-006860-a3b8hyyr	4086	16	)	)	-RRB-
cord-006860-a3b8hyyr	4087	1	under	under	IN
cord-006860-a3b8hyyr	4087	2	mdiological	mdiological	NNP
cord-006860-a3b8hyyr	4087	3	control	control	NN
cord-006860-a3b8hyyr	4087	4	.	.	.
cord-006860-a3b8hyyr	4088	1	The	the	DT
cord-006860-a3b8hyyr	4088	2	open	open	JJ
cord-006860-a3b8hyyr	4088	3	filter	filter	NN
cord-006860-a3b8hyyr	4088	4	was	be	VBD
cord-006860-a3b8hyyr	4088	5	positioned	position	VBN
cord-006860-a3b8hyyr	4088	6	above	above	IN
cord-006860-a3b8hyyr	4088	7	the	the	DT
cord-006860-a3b8hyyr	4088	8	thrembus	thrembus	NN
cord-006860-a3b8hyyr	4088	9	in	in	IN
cord-006860-a3b8hyyr	4088	10	the	the	DT
cord-006860-a3b8hyyr	4088	11	lower	low	JJR
cord-006860-a3b8hyyr	4088	12	caval	caval	NN
cord-006860-a3b8hyyr	4088	13	vein	vein	NN
cord-006860-a3b8hyyr	4088	14	:	:	:
cord-006860-a3b8hyyr	4088	15	26	26	CD
cord-006860-a3b8hyyr	4088	16	times	time	NNS
cord-006860-a3b8hyyr	4088	17	an	an	DT
cord-006860-a3b8hyyr	4088	18	Antbeor	Antbeor	NNP
cord-006860-a3b8hyyr	4088	19	system	system	NN
cord-006860-a3b8hyyr	4088	20	,	,	,
cord-006860-a3b8hyyr	4088	21	11	11	CD
cord-006860-a3b8hyyr	4088	22	times	time	NNS
cord-006860-a3b8hyyr	4088	23	an	an	DT
cord-006860-a3b8hyyr	4088	24	Anglocor	Anglocor	NNP
cord-006860-a3b8hyyr	4088	25	and	and	CC
cord-006860-a3b8hyyr	4088	26	10	10	CD
cord-006860-a3b8hyyr	4088	27	times	time	NNS
cord-006860-a3b8hyyr	4088	28	a	a	DT
cord-006860-a3b8hyyr	4088	29	Cook	Cook	NNP
cord-006860-a3b8hyyr	4088	30	filter	filter	NN
cord-006860-a3b8hyyr	4088	31	were	be	VBD
cord-006860-a3b8hyyr	4088	32	used	use	VBN
cord-006860-a3b8hyyr	4088	33	.	.	.
cord-006860-a3b8hyyr	4089	1	In	in	IN
cord-006860-a3b8hyyr	4089	2	the	the	DT
cord-006860-a3b8hyyr	4089	3	following	following	JJ
cord-006860-a3b8hyyr	4089	4	three	three	CD
cord-006860-a3b8hyyr	4089	5	days	day	NNS
cord-006860-a3b8hyyr	4089	6	up	up	IN
cord-006860-a3b8hyyr	4089	7	to	to	TO
cord-006860-a3b8hyyr	4089	8	3	3	CD
cord-006860-a3b8hyyr	4089	9	cycles	cycle	NNS
cord-006860-a3b8hyyr	4089	10	of	of	IN
cord-006860-a3b8hyyr	4089	11	lysis	lysis	NN
cord-006860-a3b8hyyr	4089	12	therapy	therapy	NN
cord-006860-a3b8hyyr	4089	13	with	with	IN
cord-006860-a3b8hyyr	4089	14	9	9	CD
cord-006860-a3b8hyyr	4089	15	Mli	Mli	NNP
cord-006860-a3b8hyyr	4089	16	U	U	NNP
cord-006860-a3b8hyyr	4089	17	of	of	IN
cord-006860-a3b8hyyr	4089	18	streptokinase	streptokinase	NNP
cord-006860-a3b8hyyr	4089	19	were	be	VBD
cord-006860-a3b8hyyr	4089	20	administered	administer	VBN
cord-006860-a3b8hyyr	4089	21	,	,	,
cord-006860-a3b8hyyr	4089	22	each	each	DT
cord-006860-a3b8hyyr	4089	23	cycle	cycle	NN
cord-006860-a3b8hyyr	4089	24	lasted	last	VBD
cord-006860-a3b8hyyr	4089	25	six	six	CD
cord-006860-a3b8hyyr	4089	26	hours	hour	NNS
cord-006860-a3b8hyyr	4089	27	.	.	.
cord-006860-a3b8hyyr	4090	1	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	4090	2	was	be	VBD
cord-006860-a3b8hyyr	4090	3	given	give	VBN
cord-006860-a3b8hyyr	4090	4	simultanously	simultanously	RB
cord-006860-a3b8hyyr	4090	5	via	via	IN
cord-006860-a3b8hyyr	4090	6	the	the	DT
cord-006860-a3b8hyyr	4090	7	filter	filter	NN
cord-006860-a3b8hyyr	4090	8	system	system	NN
cord-006860-a3b8hyyr	4090	9	in	in	IN
cord-006860-a3b8hyyr	4090	10	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	4090	11	dosages	dosage	NNS
cord-006860-a3b8hyyr	4090	12	in	in	IN
cord-006860-a3b8hyyr	4090	13	order	order	NN
cord-006860-a3b8hyyr	4090	14	to	to	TO
cord-006860-a3b8hyyr	4090	15	prolong	prolong	VB
cord-006860-a3b8hyyr	4090	16	alrIT	alrit	JJ
cord-006860-a3b8hyyr	4090	17	values	value	NNS
cord-006860-a3b8hyyr	4090	18	1.5	1.5	CD
cord-006860-a3b8hyyr	4090	19	to	to	TO
cord-006860-a3b8hyyr	4090	20	2	2	CD
cord-006860-a3b8hyyr	4090	21	times	time	NNS
cord-006860-a3b8hyyr	4090	22	the	the	DT
cord-006860-a3b8hyyr	4090	23	individual	individual	JJ
cord-006860-a3b8hyyr	4090	24	base	base	NN
cord-006860-a3b8hyyr	4090	25	line	line	NN
cord-006860-a3b8hyyr	4090	26	level	level	NN
cord-006860-a3b8hyyr	4090	27	.	.	.
cord-006860-a3b8hyyr	4091	1	Effective	effective	JJ
cord-006860-a3b8hyyr	4091	2	lysis	lysis	NN
cord-006860-a3b8hyyr	4091	3	was	be	VBD
cord-006860-a3b8hyyr	4091	4	controlled	control	VBN
cord-006860-a3b8hyyr	4091	5	by	by	IN
cord-006860-a3b8hyyr	4091	6	a	a	DT
cord-006860-a3b8hyyr	4091	7	second	second	JJ
cord-006860-a3b8hyyr	4091	8	phlebography	phlebography	NN
cord-006860-a3b8hyyr	4091	9	/	/	SYM
cord-006860-a3b8hyyr	4091	10	CT	CT	NNP
cord-006860-a3b8hyyr	4091	11	,	,	,
cord-006860-a3b8hyyr	4091	12	and	and	CC
cord-006860-a3b8hyyr	4091	13	the	the	DT
cord-006860-a3b8hyyr	4091	14	filter	filter	NN
cord-006860-a3b8hyyr	4091	15	system	system	NN
cord-006860-a3b8hyyr	4091	16	removed	remove	VBN
cord-006860-a3b8hyyr	4091	17	through	through	IN
cord-006860-a3b8hyyr	4091	18	the	the	DT
cord-006860-a3b8hyyr	4091	19	introducer	introducer	NN
cord-006860-a3b8hyyr	4091	20	sheath	sheath	NN
cord-006860-a3b8hyyr	4091	21	valve	valve	NN
cord-006860-a3b8hyyr	4091	22	.	.	.
cord-006860-a3b8hyyr	4092	1	After	after	IN
cord-006860-a3b8hyyr	4092	2	lysis	lysis	NN
cord-006860-a3b8hyyr	4092	3	therapy	therapy	NN
cord-006860-a3b8hyyr	4092	4	all	all	DT
cord-006860-a3b8hyyr	4092	5	patients	patient	NNS
cord-006860-a3b8hyyr	4092	6	were	be	VBD
cord-006860-a3b8hyyr	4092	7	put	put	VBN
cord-006860-a3b8hyyr	4092	8	on	on	IN
cord-006860-a3b8hyyr	4092	9	coumarin	coumarin	NN
cord-006860-a3b8hyyr	4092	10	with	with	IN
cord-006860-a3b8hyyr	4092	11	overlapping	overlap	VBG
cord-006860-a3b8hyyr	4092	12	heparinization	heparinization	NN
cord-006860-a3b8hyyr	4092	13	.	.	.
cord-006860-a3b8hyyr	4093	1	Successful	successful	JJ
cord-006860-a3b8hyyr	4093	2	lysis	lysis	NN
cord-006860-a3b8hyyr	4093	3	(	(	-LRB-
cord-006860-a3b8hyyr	4093	4	complete	complete	JJ
cord-006860-a3b8hyyr	4093	5	recaanlisation	recaanlisation	NN
cord-006860-a3b8hyyr	4093	6	without	without	IN
cord-006860-a3b8hyyr	4093	7	remaining	remain	VBG
cord-006860-a3b8hyyr	4093	8	thrombi	thrombi	NN
cord-006860-a3b8hyyr	4093	9	and	and	CC
cord-006860-a3b8hyyr	4093	10	lysis	lysis	NN
cord-006860-a3b8hyyr	4093	11	of	of	IN
cord-006860-a3b8hyyr	4093	12	more	more	JJR
cord-006860-a3b8hyyr	4093	13	than	than	IN
cord-006860-a3b8hyyr	4093	14	50	50	CD
cord-006860-a3b8hyyr	4093	15	per	per	IN
cord-006860-a3b8hyyr	4093	16	cent	cent	NN
cord-006860-a3b8hyyr	4093	17	of	of	IN
cord-006860-a3b8hyyr	4093	18	the	the	DT
cord-006860-a3b8hyyr	4093	19	original	original	JJ
cord-006860-a3b8hyyr	4093	20	thrombus	thrombus	NN
cord-006860-a3b8hyyr	4093	21	)	)	-RRB-
cord-006860-a3b8hyyr	4093	22	could	could	MD
cord-006860-a3b8hyyr	4093	23	be	be	VB
cord-006860-a3b8hyyr	4093	24	achieved	achieve	VBN
cord-006860-a3b8hyyr	4093	25	in	in	IN
cord-006860-a3b8hyyr	4093	26	62	62	CD
cord-006860-a3b8hyyr	4093	27	%	%	NN
cord-006860-a3b8hyyr	4093	28	(	(	-LRB-
cord-006860-a3b8hyyr	4093	29	29	29	CD
cord-006860-a3b8hyyr	4093	30	patients	patient	NNS
cord-006860-a3b8hyyr	4093	31	)	)	-RRB-
cord-006860-a3b8hyyr	4093	32	.	.	.
cord-006860-a3b8hyyr	4094	1	In	in	IN
cord-006860-a3b8hyyr	4094	2	two	two	CD
cord-006860-a3b8hyyr	4094	3	cases	case	NNS
cord-006860-a3b8hyyr	4094	4	a	a	DT
cord-006860-a3b8hyyr	4094	5	fatal	fatal	JJ
cord-006860-a3b8hyyr	4094	6	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	4094	7	embolism	embolism	NN
cord-006860-a3b8hyyr	4094	8	occurred	occur	VBD
cord-006860-a3b8hyyr	4094	9	.	.	.
cord-006860-a3b8hyyr	4095	1	5	5	CD
cord-006860-a3b8hyyr	4095	2	times	time	NNS
cord-006860-a3b8hyyr	4095	3	great	great	JJ
cord-006860-a3b8hyyr	4095	4	parts	part	NNS
cord-006860-a3b8hyyr	4095	5	of	of	IN
cord-006860-a3b8hyyr	4095	6	a	a	DT
cord-006860-a3b8hyyr	4095	7	thrombus	thrombus	NN
cord-006860-a3b8hyyr	4095	8	Were	be	VBD
cord-006860-a3b8hyyr	4095	9	captured	capture	VBN
cord-006860-a3b8hyyr	4095	10	by	by	IN
cord-006860-a3b8hyyr	4095	11	the	the	DT
cord-006860-a3b8hyyr	4095	12	filter	filter	NN
cord-006860-a3b8hyyr	4095	13	and	and	CC
cord-006860-a3b8hyyr	4095	14	could	could	MD
cord-006860-a3b8hyyr	4095	15	be	be	VB
cord-006860-a3b8hyyr	4095	16	removed	remove	VBN
cord-006860-a3b8hyyr	4095	17	with	with	IN
cord-006860-a3b8hyyr	4095	18	the	the	DT
cord-006860-a3b8hyyr	4095	19	system	system	NN
cord-006860-a3b8hyyr	4095	20	.	.	.
cord-006860-a3b8hyyr	4096	1	Due	due	IN
cord-006860-a3b8hyyr	4096	2	to	to	IN
cord-006860-a3b8hyyr	4096	3	an	an	DT
cord-006860-a3b8hyyr	4096	4	insufficient	insufficient	JJ
cord-006860-a3b8hyyr	4096	5	boparin	boparin	NN
cord-006860-a3b8hyyr	4096	6	therapy	therapy	NN
cord-006860-a3b8hyyr	4096	7	we	-PRON-	PRP
cord-006860-a3b8hyyr	4096	8	detected	detect	VBD
cord-006860-a3b8hyyr	4096	9	a	a	DT
cord-006860-a3b8hyyr	4096	10	newly	newly	RB
cord-006860-a3b8hyyr	4096	11	developed	develop	VBN
cord-006860-a3b8hyyr	4096	12	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4096	13	of	of	IN
cord-006860-a3b8hyyr	4096	14	the	the	DT
cord-006860-a3b8hyyr	4096	15	lower	low	JJR
cord-006860-a3b8hyyr	4096	16	cavul	cavul	JJ
cord-006860-a3b8hyyr	4096	17	vein	vein	NN
cord-006860-a3b8hyyr	4096	18	twice	twice	RB
cord-006860-a3b8hyyr	4096	19	after	after	IN
cord-006860-a3b8hyyr	4096	20	lysis	lysis	NN
cord-006860-a3b8hyyr	4096	21	.	.	.
cord-006860-a3b8hyyr	4097	1	This	this	DT
cord-006860-a3b8hyyr	4097	2	complication	complication	NN
cord-006860-a3b8hyyr	4097	3	could	could	MD
cord-006860-a3b8hyyr	4097	4	be	be	VB
cord-006860-a3b8hyyr	4097	5	resolved	resolve	VBN
cord-006860-a3b8hyyr	4097	6	by	by	IN
cord-006860-a3b8hyyr	4097	7	additional	additional	JJ
cord-006860-a3b8hyyr	4097	8	administration	administration	NN
cord-006860-a3b8hyyr	4097	9	of	of	IN
cord-006860-a3b8hyyr	4097	10	streptokinase	streptokinase	NNP
cord-006860-a3b8hyyr	4097	11	.	.	.
cord-006860-a3b8hyyr	4098	1	In	in	IN
cord-006860-a3b8hyyr	4098	2	nearly	nearly	RB
cord-006860-a3b8hyyr	4098	3	all	all	DT
cord-006860-a3b8hyyr	4098	4	cases	case	NNS
cord-006860-a3b8hyyr	4098	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	4098	6	found	find	VBD
cord-006860-a3b8hyyr	4098	7	extensive	extensive	JJ
cord-006860-a3b8hyyr	4098	8	hematomas	hematoma	NNS
cord-006860-a3b8hyyr	4098	9	on	on	IN
cord-006860-a3b8hyyr	4098	10	the	the	DT
cord-006860-a3b8hyyr	4098	11	catheter	catheter	NN
cord-006860-a3b8hyyr	4098	12	insertion	insertion	NN
cord-006860-a3b8hyyr	4098	13	sites	site	NNS
cord-006860-a3b8hyyr	4098	14	.	.	.
cord-006860-a3b8hyyr	4099	1	4	4	CD
cord-006860-a3b8hyyr	4099	2	patients	patient	NNS
cord-006860-a3b8hyyr	4099	3	with	with	IN
cord-006860-a3b8hyyr	4099	4	transfemoral	transfemoral	NNP
cord-006860-a3b8hyyr	4099	5	applications	application	NNS
cord-006860-a3b8hyyr	4099	6	had	have	VBD
cord-006860-a3b8hyyr	4099	7	to	to	TO
cord-006860-a3b8hyyr	4099	8	be	be	VB
cord-006860-a3b8hyyr	4099	9	transfitsed	transfitse	VBN
cord-006860-a3b8hyyr	4099	10	with	with	IN
cord-006860-a3b8hyyr	4099	11	red	red	JJ
cord-006860-a3b8hyyr	4099	12	packed	packed	JJ
cord-006860-a3b8hyyr	4099	13	cells	cell	NNS
cord-006860-a3b8hyyr	4099	14	due	due	JJ
cord-006860-a3b8hyyr	4099	15	to	to	IN
cord-006860-a3b8hyyr	4099	16	retroperitoneal	retroperitoneal	JJ
cord-006860-a3b8hyyr	4099	17	hematoma	hematoma	NN
cord-006860-a3b8hyyr	4099	18	.	.	.
cord-006860-a3b8hyyr	4100	1	One	one	CD
cord-006860-a3b8hyyr	4100	2	filter	filter	NN
cord-006860-a3b8hyyr	4100	3	system	system	NN
cord-006860-a3b8hyyr	4100	4	was	be	VBD
cord-006860-a3b8hyyr	4100	5	broken	break	VBN
cord-006860-a3b8hyyr	4100	6	after	after	IN
cord-006860-a3b8hyyr	4100	7	use	use	NN
cord-006860-a3b8hyyr	4100	8	.	.	.
cord-006860-a3b8hyyr	4101	1	Lysis	lysis	NN
cord-006860-a3b8hyyr	4101	2	of	of	IN
cord-006860-a3b8hyyr	4101	3	DVT	DVT	NNP
cord-006860-a3b8hyyr	4101	4	of	of	IN
cord-006860-a3b8hyyr	4101	5	the	the	DT
cord-006860-a3b8hyyr	4101	6	pelvic	pelvic	JJ
cord-006860-a3b8hyyr	4101	7	veins	vein	NNS
cord-006860-a3b8hyyr	4101	8	with	with	IN
cord-006860-a3b8hyyr	4101	9	UHSK	UHSK	NNP
cord-006860-a3b8hyyr	4101	10	and	and	CC
cord-006860-a3b8hyyr	4101	11	with	with	IN
cord-006860-a3b8hyyr	4101	12	the	the	DT
cord-006860-a3b8hyyr	4101	13	protection	protection	NN
cord-006860-a3b8hyyr	4101	14	of	of	IN
cord-006860-a3b8hyyr	4101	15	a	a	DT
cord-006860-a3b8hyyr	4101	16	removable	removable	JJ
cord-006860-a3b8hyyr	4101	17	temporary	temporary	JJ
cord-006860-a3b8hyyr	4101	18	filter	filter	NN
cord-006860-a3b8hyyr	4101	19	system	system	NN
cord-006860-a3b8hyyr	4101	20	situated	situate	VBN
cord-006860-a3b8hyyr	4101	21	in	in	IN
cord-006860-a3b8hyyr	4101	22	the	the	DT
cord-006860-a3b8hyyr	4101	23	lower	low	JJR
cord-006860-a3b8hyyr	4101	24	caval	caval	NN
cord-006860-a3b8hyyr	4101	25	vein	vein	NN
cord-006860-a3b8hyyr	4101	26	enables	enable	VBZ
cord-006860-a3b8hyyr	4101	27	us	-PRON-	PRP
cord-006860-a3b8hyyr	4101	28	to	to	TO
cord-006860-a3b8hyyr	4101	29	carry	carry	VB
cord-006860-a3b8hyyr	4101	30	out	out	RP
cord-006860-a3b8hyyr	4101	31	an	an	DT
cord-006860-a3b8hyyr	4101	32	effective	effective	JJ
cord-006860-a3b8hyyr	4101	33	therapy	therapy	NN
cord-006860-a3b8hyyr	4101	34	.	.	.
cord-006860-a3b8hyyr	4102	1	The	the	DT
cord-006860-a3b8hyyr	4102	2	filter	filter	NN
cord-006860-a3b8hyyr	4102	3	systems	system	NNS
cord-006860-a3b8hyyr	4102	4	,	,	,
cord-006860-a3b8hyyr	4102	5	however	however	RB
cord-006860-a3b8hyyr	4102	6	,	,	,
cord-006860-a3b8hyyr	4102	7	have	have	VBP
cord-006860-a3b8hyyr	4102	8	to	to	TO
cord-006860-a3b8hyyr	4102	9	be	be	VB
cord-006860-a3b8hyyr	4102	10	ameliorated	ameliorate	VBN
cord-006860-a3b8hyyr	4102	11	in	in	IN
cord-006860-a3b8hyyr	4102	12	order	order	NN
cord-006860-a3b8hyyr	4102	13	to	to	TO
cord-006860-a3b8hyyr	4102	14	better	better	RB
cord-006860-a3b8hyyr	4102	15	prevent	prevent	VB
cord-006860-a3b8hyyr	4102	16	fatal	fatal	JJ
cord-006860-a3b8hyyr	4102	17	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	4102	18	embolism	embolism	NN
cord-006860-a3b8hyyr	4102	19	.	.	.
cord-006860-a3b8hyyr	4103	1	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	4103	2	should	should	MD
cord-006860-a3b8hyyr	4103	3	be	be	VB
cord-006860-a3b8hyyr	4103	4	administered	administer	VBN
cord-006860-a3b8hyyr	4103	5	at	at	IN
cord-006860-a3b8hyyr	4103	6	least	least	JJS
cord-006860-a3b8hyyr	4103	7	in	in	IN
cord-006860-a3b8hyyr	4103	8	the	the	DT
cord-006860-a3b8hyyr	4103	9	remainder	remainder	NN
cord-006860-a3b8hyyr	4103	10	of	of	IN
cord-006860-a3b8hyyr	4103	11	the	the	DT
cord-006860-a3b8hyyr	4103	12	day	day	NN
cord-006860-a3b8hyyr	4103	13	of	of	IN
cord-006860-a3b8hyyr	4103	14	lysis	lysis	NN
cord-006860-a3b8hyyr	4103	15	.	.	.
cord-006860-a3b8hyyr	4104	1	The	the	DT
cord-006860-a3b8hyyr	4104	2	insertion	insertion	NN
cord-006860-a3b8hyyr	4104	3	site	site	NN
cord-006860-a3b8hyyr	4104	4	should	should	MD
cord-006860-a3b8hyyr	4104	5	be	be	VB
cord-006860-a3b8hyyr	4104	6	the	the	DT
cord-006860-a3b8hyyr	4104	7	enbital	enbital	JJ
cord-006860-a3b8hyyr	4104	8	vein	vein	NN
cord-006860-a3b8hyyr	4104	9	because	because	IN
cord-006860-a3b8hyyr	4104	10	compression	compression	NN
cord-006860-a3b8hyyr	4104	11	for	for	IN
cord-006860-a3b8hyyr	4104	12	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4104	13	complication	complication	NN
cord-006860-a3b8hyyr	4104	14	is	be	VBZ
cord-006860-a3b8hyyr	4104	15	easily	easily	RB
cord-006860-a3b8hyyr	4104	16	feasible	feasible	JJ
cord-006860-a3b8hyyr	4104	17	at	at	IN
cord-006860-a3b8hyyr	4104	18	this	this	DT
cord-006860-a3b8hyyr	4104	19	location	location	NN
cord-006860-a3b8hyyr	4104	20	.	.	.
cord-006860-a3b8hyyr	4105	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4105	2	report	report	VBP
cord-006860-a3b8hyyr	4105	3	about	about	RB
cord-006860-a3b8hyyr	4105	4	seven	seven	CD
cord-006860-a3b8hyyr	4105	5	of	of	IN
cord-006860-a3b8hyyr	4105	6	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4105	7	patients	patient	NNS
cord-006860-a3b8hyyr	4105	8	(	(	-LRB-
cord-006860-a3b8hyyr	4105	9	pts	pt	NNS
cord-006860-a3b8hyyr	4105	10	.	.	.
cord-006860-a3b8hyyr	4105	11	)	)	-RRB-
cord-006860-a3b8hyyr	4106	1	with	with	IN
cord-006860-a3b8hyyr	4106	2	BCS	BCS	NNP
cord-006860-a3b8hyyr	4106	3	treated	treat	VBN
cord-006860-a3b8hyyr	4106	4	by	by	IN
cord-006860-a3b8hyyr	4106	5	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4106	6	therapy	therapy	NN
cord-006860-a3b8hyyr	4106	7	(	(	-LRB-
cord-006860-a3b8hyyr	4106	8	5	5	CD
cord-006860-a3b8hyyr	4106	9	female	female	JJ
cord-006860-a3b8hyyr	4106	10	,	,	,
cord-006860-a3b8hyyr	4106	11	2	2	CD
cord-006860-a3b8hyyr	4106	12	male	male	NN
cord-006860-a3b8hyyr	4106	13	,	,	,
cord-006860-a3b8hyyr	4106	14	age	age	NN
cord-006860-a3b8hyyr	4106	15	27	27	CD
cord-006860-a3b8hyyr	4106	16	,	,	,
cord-006860-a3b8hyyr	4106	17	6	6	CD
cord-006860-a3b8hyyr	4106	18	years	year	NNS
cord-006860-a3b8hyyr	4106	19	+	+	SYM
cord-006860-a3b8hyyr	4106	20	8)	8)	NN
cord-006860-a3b8hyyr	4106	21	.	.	.
cord-006860-a3b8hyyr	4107	1	Only	only	RB
cord-006860-a3b8hyyr	4107	2	one	one	CD
cord-006860-a3b8hyyr	4107	3	case	case	NN
cord-006860-a3b8hyyr	4107	4	was	be	VBD
cord-006860-a3b8hyyr	4107	5	of	of	IN
cord-006860-a3b8hyyr	4107	6	unknown	unknown	JJ
cord-006860-a3b8hyyr	4107	7	origin	origin	NN
cord-006860-a3b8hyyr	4107	8	while	while	IN
cord-006860-a3b8hyyr	4107	9	in	in	IN
cord-006860-a3b8hyyr	4107	10	four	four	CD
cord-006860-a3b8hyyr	4107	11	pts	pt	NNS
cord-006860-a3b8hyyr	4107	12	.	.	.
cord-006860-a3b8hyyr	4108	1	myeloproliferative	myeloproliferative	NNP
cord-006860-a3b8hyyr	4108	2	syndromes	syndromes	NNPS
cord-006860-a3b8hyyr	4108	3	,	,	,
cord-006860-a3b8hyyr	4108	4	in	in	IN
cord-006860-a3b8hyyr	4108	5	one	one	CD
cord-006860-a3b8hyyr	4108	6	protein	protein	NN
cord-006860-a3b8hyyr	4108	7	C	c	NN
cord-006860-a3b8hyyr	4108	8	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4108	9	and	and	CC
cord-006860-a3b8hyyr	4108	10	in	in	IN
cord-006860-a3b8hyyr	4108	11	another	another	DT
cord-006860-a3b8hyyr	4108	12	one	one	NN
cord-006860-a3b8hyyr	4108	13	Morbus	Morbus	NNP
cord-006860-a3b8hyyr	4108	14	Behcet	Behcet	NNP
cord-006860-a3b8hyyr	4108	15	was	be	VBD
cord-006860-a3b8hyyr	4108	16	detected	detect	VBN
cord-006860-a3b8hyyr	4108	17	In	in	IN
cord-006860-a3b8hyyr	4108	18	five	five	CD
cord-006860-a3b8hyyr	4108	19	pts	pt	NNS
cord-006860-a3b8hyyr	4108	20	.	.	.
cord-006860-a3b8hyyr	4109	1	chronical	chronical	NNP
cord-006860-a3b8hyyr	4109	2	and	and	CC
cord-006860-a3b8hyyr	4109	3	in	in	IN
cord-006860-a3b8hyyr	4109	4	two	two	CD
cord-006860-a3b8hyyr	4109	5	acute	acute	JJ
cord-006860-a3b8hyyr	4109	6	BCS	BCS	NNP
cord-006860-a3b8hyyr	4109	7	was	be	VBD
cord-006860-a3b8hyyr	4109	8	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	4109	9	.	.	.
cord-006860-a3b8hyyr	4110	1	As	as	IN
cord-006860-a3b8hyyr	4110	2	complications	complication	NNS
cord-006860-a3b8hyyr	4110	3	were	be	VBD
cord-006860-a3b8hyyr	4110	4	found	find	VBN
cord-006860-a3b8hyyr	4110	5	:	:	:
cord-006860-a3b8hyyr	4110	6	In	in	IN
cord-006860-a3b8hyyr	4110	7	three	three	CD
cord-006860-a3b8hyyr	4110	8	pts•	pts•	NNP
cord-006860-a3b8hyyr	4110	9	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4110	10	of	of	IN
cord-006860-a3b8hyyr	4110	11	vena	vena	NNP
cord-006860-a3b8hyyr	4110	12	iv	iv	NNP
cord-006860-a3b8hyyr	4110	13	.	.	.
cord-006860-a3b8hyyr	4110	14	)	)	-RRB-
cord-006860-a3b8hyyr	4111	1	cava	cava	NNP
cord-006860-a3b8hyyr	4111	2	,	,	,
cord-006860-a3b8hyyr	4111	3	in	in	IN
cord-006860-a3b8hyyr	4111	4	one	one	CD
cord-006860-a3b8hyyr	4111	5	ofv	ofv	NN
cord-006860-a3b8hyyr	4111	6	.	.	.
cord-006860-a3b8hyyr	4112	1	porta	porta	NNP
cord-006860-a3b8hyyr	4112	2	and	and	CC
cord-006860-a3b8hyyr	4112	3	v.	v.	NNP
cord-006860-a3b8hyyr	4112	4	lienalis	lienalis	NNP
cord-006860-a3b8hyyr	4112	5	,	,	,
cord-006860-a3b8hyyr	4112	6	in	in	IN
cord-006860-a3b8hyyr	4112	7	one	one	CD
cord-006860-a3b8hyyr	4112	8	more	more	JJR
cord-006860-a3b8hyyr	4112	9	of	of	IN
cord-006860-a3b8hyyr	4112	10	v•	v•	JJ
cord-006860-a3b8hyyr	4112	11	porta	porta	NNP
cord-006860-a3b8hyyr	4112	12	and	and	CC
cord-006860-a3b8hyyr	4112	13	v•	v•	NNP
cord-006860-a3b8hyyr	4112	14	cava	cava	NNP
cord-006860-a3b8hyyr	4112	15	.	.	.
cord-006860-a3b8hyyr	4113	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4113	2	treated	treat	VBD
cord-006860-a3b8hyyr	4113	3	just	just	RB
cord-006860-a3b8hyyr	4113	4	one	one	CD
cord-006860-a3b8hyyr	4113	5	patient	patient	NN
cord-006860-a3b8hyyr	4113	6	with	with	IN
cord-006860-a3b8hyyr	4113	7	urokinase	urokinase	NNP
cord-006860-a3b8hyyr	4113	8	(	(	-LRB-
cord-006860-a3b8hyyr	4113	9	3	3	CD
cord-006860-a3b8hyyr	4113	10	x	x	SYM
cord-006860-a3b8hyyr	4113	11	800.000	800.000	CD
cord-006860-a3b8hyyr	4113	12	IU	IU	NNP
cord-006860-a3b8hyyr	4113	13	/	/	,
cord-006860-a3b8hyyr	4113	14	d	d	NN
cord-006860-a3b8hyyr	4113	15	for	for	IN
cord-006860-a3b8hyyr	4113	16	18	18	CD
cord-006860-a3b8hyyr	4113	17	days	day	NNS
cord-006860-a3b8hyyr	4113	18	)	)	-RRB-
cord-006860-a3b8hyyr	4113	19	.	.	.
cord-006860-a3b8hyyr	4114	1	Four	four	CD
cord-006860-a3b8hyyr	4114	2	pts	pts	NN
cord-006860-a3b8hyyr	4114	3	.	.	.
cord-006860-a3b8hyyr	4114	4	were	be	VBD
cord-006860-a3b8hyyr	4114	5	treated	treat	VBN
cord-006860-a3b8hyyr	4114	6	with	with	IN
cord-006860-a3b8hyyr	4114	7	rt	rt	NNP
cord-006860-a3b8hyyr	4114	8	-	-	HYPH
cord-006860-a3b8hyyr	4114	9	PA	PA	NNP
cord-006860-a3b8hyyr	4114	10	in	in	IN
cord-006860-a3b8hyyr	4114	11	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4114	12	of	of	IN
cord-006860-a3b8hyyr	4114	13	25	25	CD
cord-006860-a3b8hyyr	4114	14	to	to	TO
cord-006860-a3b8hyyr	4114	15	50	50	CD
cord-006860-a3b8hyyr	4114	16	mg	mg	NN
cord-006860-a3b8hyyr	4114	17	/	/	SYM
cord-006860-a3b8hyyr	4114	18	d	d	NNP
cord-006860-a3b8hyyr	4114	19	(	(	-LRB-
cord-006860-a3b8hyyr	4114	20	for	for	IN
cord-006860-a3b8hyyr	4114	21	a	a	DT
cord-006860-a3b8hyyr	4114	22	period	period	NN
cord-006860-a3b8hyyr	4114	23	of	of	IN
cord-006860-a3b8hyyr	4114	24	up	up	IN
cord-006860-a3b8hyyr	4114	25	to	to	TO
cord-006860-a3b8hyyr	4114	26	14	14	CD
cord-006860-a3b8hyyr	4114	27	days	day	NNS
cord-006860-a3b8hyyr	4114	28	)	)	-RRB-
cord-006860-a3b8hyyr	4114	29	and	and	CC
cord-006860-a3b8hyyr	4114	30	continuous	continuous	JJ
cord-006860-a3b8hyyr	4114	31	heparin	heparin	NN
cord-006860-a3b8hyyr	4114	32	infusion	infusion	NN
cord-006860-a3b8hyyr	4114	33	.	.	.
cord-006860-a3b8hyyr	4115	1	High	high	JJ
cord-006860-a3b8hyyr	4115	2	doses	dose	NNS
cord-006860-a3b8hyyr	4115	3	of	of	IN
cord-006860-a3b8hyyr	4115	4	rt	rt	NNP
cord-006860-a3b8hyyr	4115	5	-	-	HYPH
cord-006860-a3b8hyyr	4115	6	PA	PA	NNP
cord-006860-a3b8hyyr	4115	7	(	(	-LRB-
cord-006860-a3b8hyyr	4115	8	80	80	CD
cord-006860-a3b8hyyr	4115	9	to	to	TO
cord-006860-a3b8hyyr	4115	10	120	120	CD
cord-006860-a3b8hyyr	4115	11	mg	mg	NN
cord-006860-a3b8hyyr	4115	12	/	/	SYM
cord-006860-a3b8hyyr	4115	13	d	d	XX
cord-006860-a3b8hyyr	4115	14	for	for	IN
cord-006860-a3b8hyyr	4115	15	one	one	CD
cord-006860-a3b8hyyr	4115	16	or	or	CC
cord-006860-a3b8hyyr	4115	17	four	four	CD
cord-006860-a3b8hyyr	4115	18	days	day	NNS
cord-006860-a3b8hyyr	4115	19	)	)	-RRB-
cord-006860-a3b8hyyr	4115	20	were	be	VBD
cord-006860-a3b8hyyr	4115	21	given	give	VBN
cord-006860-a3b8hyyr	4115	22	in	in	IN
cord-006860-a3b8hyyr	4115	23	one	one	CD
cord-006860-a3b8hyyr	4115	24	case	case	NN
cord-006860-a3b8hyyr	4115	25	of	of	IN
cord-006860-a3b8hyyr	4115	26	acute	acute	NN
cord-006860-a3b8hyyr	4115	27	and	and	CC
cord-006860-a3b8hyyr	4115	28	one	one	CD
cord-006860-a3b8hyyr	4115	29	of	of	IN
cord-006860-a3b8hyyr	4115	30	chronic	chronic	JJ
cord-006860-a3b8hyyr	4115	31	BCS	BCS	NNP
cord-006860-a3b8hyyr	4115	32	.	.	.
cord-006860-a3b8hyyr	4116	1	Partial	partial	JJ
cord-006860-a3b8hyyr	4116	2	(	(	-LRB-
cord-006860-a3b8hyyr	4116	3	after	after	IN
cord-006860-a3b8hyyr	4116	4	high	high	JJ
cord-006860-a3b8hyyr	4116	5	-	-	HYPH
cord-006860-a3b8hyyr	4116	6	dose	dose	NN
cord-006860-a3b8hyyr	4116	7	rt	rt	NNP
cord-006860-a3b8hyyr	4116	8	-	-	HYPH
cord-006860-a3b8hyyr	4116	9	PA	PA	NNP
cord-006860-a3b8hyyr	4116	10	nearly	nearly	RB
cord-006860-a3b8hyyr	4116	11	complete	complete	JJ
cord-006860-a3b8hyyr	4116	12	)	)	-RRB-
cord-006860-a3b8hyyr	4116	13	recanalisation	recanalisation	NN
cord-006860-a3b8hyyr	4116	14	of	of	IN
cord-006860-a3b8hyyr	4116	15	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	4116	16	hepaticel	hepaticel	JJ
cord-006860-a3b8hyyr	4116	17	veins	vein	NNS
cord-006860-a3b8hyyr	4116	18	was	be	VBD
cord-006860-a3b8hyyr	4116	19	only	only	RB
cord-006860-a3b8hyyr	4116	20	achieved	achieve	VBN
cord-006860-a3b8hyyr	4116	21	in	in	IN
cord-006860-a3b8hyyr	4116	22	the	the	DT
cord-006860-a3b8hyyr	4116	23	two	two	CD
cord-006860-a3b8hyyr	4116	24	acute	acute	JJ
cord-006860-a3b8hyyr	4116	25	cases	case	NNS
cord-006860-a3b8hyyr	4116	26	of	of	IN
cord-006860-a3b8hyyr	4116	27	BCS	BCS	NNP
cord-006860-a3b8hyyr	4116	28	.	.	.
cord-006860-a3b8hyyr	4117	1	No	no	DT
cord-006860-a3b8hyyr	4117	2	significant	significant	JJ
cord-006860-a3b8hyyr	4117	3	recanalisation	recanalisation	NN
cord-006860-a3b8hyyr	4117	4	was	be	VBD
cord-006860-a3b8hyyr	4117	5	proven	prove	VBN
cord-006860-a3b8hyyr	4117	6	in	in	IN
cord-006860-a3b8hyyr	4117	7	hepatical	hepatical	JJ
cord-006860-a3b8hyyr	4117	8	veins	vein	NNS
cord-006860-a3b8hyyr	4117	9	of	of	IN
cord-006860-a3b8hyyr	4117	10	chronic	chronic	JJ
cord-006860-a3b8hyyr	4117	11	BCS	BCS	NNP
cord-006860-a3b8hyyr	4117	12	.	.	.
cord-006860-a3b8hyyr	4118	1	Three	three	CD
cord-006860-a3b8hyyr	4118	2	times	time	NNS
cord-006860-a3b8hyyr	4118	3	complete	complete	JJ
cord-006860-a3b8hyyr	4118	4	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	4118	5	of	of	IN
cord-006860-a3b8hyyr	4118	6	v.	v.	NNP
cord-006860-a3b8hyyr	4118	7	cava	cava	NNP
cord-006860-a3b8hyyr	4118	8	thrombosis	thrombosis	NNP
cord-006860-a3b8hyyr	4118	9	(	(	-LRB-
cord-006860-a3b8hyyr	4118	10	two	two	CD
cord-006860-a3b8hyyr	4118	11	after	after	IN
cord-006860-a3b8hyyr	4118	12	highdose	highdose	NN
cord-006860-a3b8hyyr	4118	13	therapy	therapy	NN
cord-006860-a3b8hyyr	4118	14	)	)	-RRB-
cord-006860-a3b8hyyr	4118	15	and	and	CC
cord-006860-a3b8hyyr	4118	16	one	one	CD
cord-006860-a3b8hyyr	4118	17	partial	partial	JJ
cord-006860-a3b8hyyr	4118	18	lysis	lysis	NN
cord-006860-a3b8hyyr	4118	19	could	could	MD
cord-006860-a3b8hyyr	4118	20	be	be	VB
cord-006860-a3b8hyyr	4118	21	attained	attain	VBN
cord-006860-a3b8hyyr	4118	22	.	.	.
cord-006860-a3b8hyyr	4119	1	In	in	IN
cord-006860-a3b8hyyr	4119	2	one	one	CD
cord-006860-a3b8hyyr	4119	3	patient	patient	JJ
cord-006860-a3b8hyyr	4119	4	partial	partial	JJ
cord-006860-a3b8hyyr	4119	5	lysis	lysis	NN
cord-006860-a3b8hyyr	4119	6	of	of	IN
cord-006860-a3b8hyyr	4119	7	v.	v.	CC
cord-006860-a3b8hyyr	4119	8	porta	porta	NNP
cord-006860-a3b8hyyr	4119	9	and	and	CC
cord-006860-a3b8hyyr	4119	10	in	in	IN
cord-006860-a3b8hyyr	4119	11	another	another	DT
cord-006860-a3b8hyyr	4119	12	one	one	CD
cord-006860-a3b8hyyr	4119	13	of	of	IN
cord-006860-a3b8hyyr	4119	14	v.	v.	NNP
cord-006860-a3b8hyyr	4119	15	lienalis	lienalis	NNP
cord-006860-a3b8hyyr	4119	16	was	be	VBD
cord-006860-a3b8hyyr	4119	17	found	find	VBN
cord-006860-a3b8hyyr	4119	18	.	.	.
cord-006860-a3b8hyyr	4120	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	4120	2	complete	complete	JJ
cord-006860-a3b8hyyr	4120	3	recanatisation	recanatisation	NN
cord-006860-a3b8hyyr	4120	4	of	of	IN
cord-006860-a3b8hyyr	4120	5	v.	v.	NNP
cord-006860-a3b8hyyr	4120	6	porta	porta	NNP
cord-006860-a3b8hyyr	4120	7	followed	follow	VBD
cord-006860-a3b8hyyr	4120	8	local	local	JJ
cord-006860-a3b8hyyr	4120	9	rt	rt	NNP
cord-006860-a3b8hyyr	4120	10	-	-	HYPH
cord-006860-a3b8hyyr	4120	11	PA	PA	NNP
cord-006860-a3b8hyyr	4120	12	lysis	lysis	NN
cord-006860-a3b8hyyr	4120	13	during	during	IN
cord-006860-a3b8hyyr	4120	14	surgical	surgical	JJ
cord-006860-a3b8hyyr	4120	15	intervention	intervention	NN
cord-006860-a3b8hyyr	4120	16	.	.	.
cord-006860-a3b8hyyr	4121	1	In	in	IN
cord-006860-a3b8hyyr	4121	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4121	3	two	two	CD
cord-006860-a3b8hyyr	4121	4	pts	pt	NNS
cord-006860-a3b8hyyr	4121	5	.	.	.
cord-006860-a3b8hyyr	4122	1	with	with	IN
cord-006860-a3b8hyyr	4122	2	acute	acute	JJ
cord-006860-a3b8hyyr	4122	3	BCS	BCS	NNP
cord-006860-a3b8hyyr	4122	4	significant	significant	JJ
cord-006860-a3b8hyyr	4122	5	improvement	improvement	NN
cord-006860-a3b8hyyr	4122	6	of	of	IN
cord-006860-a3b8hyyr	4122	7	hepatical	hepatical	JJ
cord-006860-a3b8hyyr	4122	8	venous	venous	JJ
cord-006860-a3b8hyyr	4122	9	flow	flow	NN
cord-006860-a3b8hyyr	4122	10	could	could	MD
cord-006860-a3b8hyyr	4122	11	be	be	VB
cord-006860-a3b8hyyr	4122	12	measured	measure	VBN
cord-006860-a3b8hyyr	4122	13	after	after	IN
cord-006860-a3b8hyyr	4122	14	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4122	15	therapy•	therapy•	NNP
cord-006860-a3b8hyyr	4123	1	In	in	IN
cord-006860-a3b8hyyr	4123	2	chronic	chronic	JJ
cord-006860-a3b8hyyr	4123	3	BCS	BCS	NNP
cord-006860-a3b8hyyr	4123	4	hepatical	hepatical	NNP
cord-006860-a3b8hyyr	4123	5	venous	venous	JJ
cord-006860-a3b8hyyr	4123	6	flow	flow	NN
cord-006860-a3b8hyyr	4123	7	did	do	VBD
cord-006860-a3b8hyyr	4123	8	not	not	RB
cord-006860-a3b8hyyr	4123	9	improve	improve	VB
cord-006860-a3b8hyyr	4123	10	while	while	IN
cord-006860-a3b8hyyr	4123	11	the	the	DT
cord-006860-a3b8hyyr	4123	12	complication	complication	NN
cord-006860-a3b8hyyr	4123	13	of	of	IN
cord-006860-a3b8hyyr	4123	14	v.	v.	NNP
cord-006860-a3b8hyyr	4123	15	cava	cava	NNP
cord-006860-a3b8hyyr	4123	16	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4123	17	could	could	MD
cord-006860-a3b8hyyr	4123	18	eventually	eventually	RB
cord-006860-a3b8hyyr	4123	19	be	be	VB
cord-006860-a3b8hyyr	4123	20	treated	treat	VBN
cord-006860-a3b8hyyr	4123	21	successfully	successfully	RB
cord-006860-a3b8hyyr	4123	22	.	.	.
cord-006860-a3b8hyyr	4124	1	Probably	probably	RB
cord-006860-a3b8hyyr	4124	2	due	due	JJ
cord-006860-a3b8hyyr	4124	3	to	to	IN
cord-006860-a3b8hyyr	4124	4	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4124	5	therapy	therapy	NN
cord-006860-a3b8hyyr	4124	6	one	one	CD
cord-006860-a3b8hyyr	4124	7	case	case	NN
cord-006860-a3b8hyyr	4124	8	of	of	IN
cord-006860-a3b8hyyr	4124	9	esophageal	esophageal	JJ
cord-006860-a3b8hyyr	4124	10	varix	varix	NN
cord-006860-a3b8hyyr	4124	11	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4124	12	occurred	occur	VBD
cord-006860-a3b8hyyr	4124	13	.	.	.
cord-006860-a3b8hyyr	4125	1	The	the	DT
cord-006860-a3b8hyyr	4125	2	benefit	benefit	NN
cord-006860-a3b8hyyr	4125	3	of	of	IN
cord-006860-a3b8hyyr	4125	4	flbrinolytic	flbrinolytic	JJ
cord-006860-a3b8hyyr	4125	5	therapy	therapy	NN
cord-006860-a3b8hyyr	4125	6	of	of	IN
cord-006860-a3b8hyyr	4125	7	BCS	BCS	NNP
cord-006860-a3b8hyyr	4125	8	seems	seem	VBZ
cord-006860-a3b8hyyr	4125	9	to	to	TO
cord-006860-a3b8hyyr	4125	10	be	be	VB
cord-006860-a3b8hyyr	4125	11	influenced	influence	VBN
cord-006860-a3b8hyyr	4125	12	by	by	IN
cord-006860-a3b8hyyr	4125	13	the	the	DT
cord-006860-a3b8hyyr	4125	14	dur	dur	NN
cord-006860-a3b8hyyr	4125	15	~	~	NFP
cord-006860-a3b8hyyr	4125	16	ion	ion	NN
cord-006860-a3b8hyyr	4125	17	of	of	IN
cord-006860-a3b8hyyr	4125	18	the	the	DT
cord-006860-a3b8hyyr	4125	19	disease•	disease•	NNP
cord-006860-a3b8hyyr	4126	1	According	accord	VBG
cord-006860-a3b8hyyr	4126	2	to	to	IN
cord-006860-a3b8hyyr	4126	3	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4126	4	results	result	NNS
cord-006860-a3b8hyyr	4126	5	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4126	6	therapy	therapy	NN
cord-006860-a3b8hyyr	4126	7	should	should	MD
cord-006860-a3b8hyyr	4126	8	be	be	VB
cord-006860-a3b8hyyr	4126	9	considered	consider	VBN
cord-006860-a3b8hyyr	4126	10	in	in	IN
cord-006860-a3b8hyyr	4126	11	cases	case	NNS
cord-006860-a3b8hyyr	4126	12	of	of	IN
cord-006860-a3b8hyyr	4126	13	acute	acute	JJ
cord-006860-a3b8hyyr	4126	14	BCS	BCS	NNP
cord-006860-a3b8hyyr	4126	15	as	as	RB
cord-006860-a3b8hyyr	4126	16	well	well	RB
cord-006860-a3b8hyyr	4126	17	as	as	IN
cord-006860-a3b8hyyr	4126	18	in	in	IN
cord-006860-a3b8hyyr	4126	19	the	the	DT
cord-006860-a3b8hyyr	4126	20	above	above	JJ
cord-006860-a3b8hyyr	4127	1	mentioned	mention	VBD
cord-006860-a3b8hyyr	4127	2	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	4127	3	complications•	complications•	RB
cord-006860-a3b8hyyr	4128	1	Recent	recent	JJ
cord-006860-a3b8hyyr	4128	2	studies	study	NNS
cord-006860-a3b8hyyr	4128	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	4128	4	that	that	IN
cord-006860-a3b8hyyr	4128	5	transport	transport	NN
cord-006860-a3b8hyyr	4128	6	of	of	IN
cord-006860-a3b8hyyr	4128	7	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	4128	8	agents	agent	NNS
cord-006860-a3b8hyyr	4128	9	through	through	IN
cord-006860-a3b8hyyr	4128	10	the	the	DT
cord-006860-a3b8hyyr	4128	11	clot	clot	NN
cord-006860-a3b8hyyr	4128	12	can	can	MD
cord-006860-a3b8hyyr	4128	13	play	play	VB
cord-006860-a3b8hyyr	4128	14	a	a	DT
cord-006860-a3b8hyyr	4128	15	major	major	JJ
cord-006860-a3b8hyyr	4128	16	role	role	NN
cord-006860-a3b8hyyr	4128	17	in	in	IN
cord-006860-a3b8hyyr	4128	18	determining	determine	VBG
cord-006860-a3b8hyyr	4128	19	the	the	DT
cord-006860-a3b8hyyr	4128	20	reperfusion	reperfusion	NN
cord-006860-a3b8hyyr	4128	21	time	time	NN
cord-006860-a3b8hyyr	4128	22	needed	need	VBN
cord-006860-a3b8hyyr	4128	23	for	for	IN
cord-006860-a3b8hyyr	4128	24	thrombolysis	thrombolysis	NN
cord-006860-a3b8hyyr	4128	25	.	.	.
cord-006860-a3b8hyyr	4129	1	As	as	IN
cord-006860-a3b8hyyr	4129	2	the	the	DT
cord-006860-a3b8hyyr	4129	3	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	4129	4	of	of	IN
cord-006860-a3b8hyyr	4129	5	this	this	DT
cord-006860-a3b8hyyr	4129	6	phenomena	phenomenon	NNS
cord-006860-a3b8hyyr	4129	7	are	be	VBP
cord-006860-a3b8hyyr	4129	8	rather	rather	RB
cord-006860-a3b8hyyr	4129	9	unclear	unclear	JJ
cord-006860-a3b8hyyr	4129	10	we	-PRON-	PRP
cord-006860-a3b8hyyr	4129	11	studied	study	VBD
cord-006860-a3b8hyyr	4129	12	fibrin	fibrin	NN
cord-006860-a3b8hyyr	4129	13	(	(	-LRB-
cord-006860-a3b8hyyr	4129	14	0.4	0.4	CD
cord-006860-a3b8hyyr	4129	15	-	-	SYM
cord-006860-a3b8hyyr	4129	16	1.5	1.5	CD
cord-006860-a3b8hyyr	4129	17	~tM	~tM	NFP
cord-006860-a3b8hyyr	4129	18	)	)	-RRB-
cord-006860-a3b8hyyr	4130	1	clot	clot	NN
cord-006860-a3b8hyyr	4130	2	lysis	lysis	NN
cord-006860-a3b8hyyr	4130	3	by	by	IN
cord-006860-a3b8hyyr	4130	4	plasmin	plasmin	NNP
cord-006860-a3b8hyyr	4130	5	(	(	-LRB-
cord-006860-a3b8hyyr	4130	6	30	30	CD
cord-006860-a3b8hyyr	4130	7	nM	nm	NN
cord-006860-a3b8hyyr	4130	8	)	)	-RRB-
cord-006860-a3b8hyyr	4130	9	presented	present	VBN
cord-006860-a3b8hyyr	4130	10	outside	outside	RB
cord-006860-a3b8hyyr	4130	11	or	or	CC
cord-006860-a3b8hyyr	4130	12	inside	inside	IN
cord-006860-a3b8hyyr	4130	13	the	the	DT
cord-006860-a3b8hyyr	4130	14	clot	clot	NN
cord-006860-a3b8hyyr	4130	15	in	in	IN
cord-006860-a3b8hyyr	4130	16	purified	purify	VBN
cord-006860-a3b8hyyr	4130	17	system	system	NN
cord-006860-a3b8hyyr	4130	18	(	(	-LRB-
cord-006860-a3b8hyyr	4130	19	Tris	Tris	NNP
cord-006860-a3b8hyyr	4130	20	-	-	HYPH
cord-006860-a3b8hyyr	4130	21	HC1	HC1	NNP
cord-006860-a3b8hyyr	4130	22	buffer	buffer	NN
cord-006860-a3b8hyyr	4130	23	,	,	,
cord-006860-a3b8hyyr	4130	24	37	37	CD
cord-006860-a3b8hyyr	4130	25	°	°	NN
cord-006860-a3b8hyyr	4130	26	C	c	NN
cord-006860-a3b8hyyr	4130	27	)	)	-RRB-
cord-006860-a3b8hyyr	4130	28	.	.	.
cord-006860-a3b8hyyr	4131	1	The	the	DT
cord-006860-a3b8hyyr	4131	2	clots	clot	NNS
cord-006860-a3b8hyyr	4131	3	was	be	VBD
cord-006860-a3b8hyyr	4131	4	formed	form	VBN
cord-006860-a3b8hyyr	4131	5	by	by	IN
cord-006860-a3b8hyyr	4131	6	addition	addition	NN
cord-006860-a3b8hyyr	4131	7	of	of	IN
cord-006860-a3b8hyyr	4131	8	CaC12	CaC12	NNP
cord-006860-a3b8hyyr	4131	9	(	(	-LRB-
cord-006860-a3b8hyyr	4131	10	30	30	CD
cord-006860-a3b8hyyr	4131	11	mM	mm	CD
cord-006860-a3b8hyyr	4131	12	)	)	-RRB-
cord-006860-a3b8hyyr	4131	13	,	,	,
cord-006860-a3b8hyyr	4131	14	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	4131	15	(	(	-LRB-
cord-006860-a3b8hyyr	4131	16	1	1	CD
cord-006860-a3b8hyyr	4131	17	U	U	NNP
cord-006860-a3b8hyyr	4131	18	/	/	SYM
cord-006860-a3b8hyyr	4131	19	ml	ml	NN
cord-006860-a3b8hyyr	4131	20	)	)	-RRB-
cord-006860-a3b8hyyr	4131	21	and	and	CC
cord-006860-a3b8hyyr	4131	22	human	human	JJ
cord-006860-a3b8hyyr	4131	23	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4131	24	(	(	-LRB-
cord-006860-a3b8hyyr	4131	25	6	6	CD
cord-006860-a3b8hyyr	4131	26	NIH	NIH	NNP
cord-006860-a3b8hyyr	4131	27	/	/	SYM
cord-006860-a3b8hyyr	4131	28	ml)t	ml)t	NN
cord-006860-a3b8hyyr	4132	1	The	the	DT
cord-006860-a3b8hyyr	4132	2	lysis	lysis	NN
cord-006860-a3b8hyyr	4132	3	degree	degree	NN
cord-006860-a3b8hyyr	4132	4	was	be	VBD
cord-006860-a3b8hyyr	4132	5	determined	determine	VBN
cord-006860-a3b8hyyr	4132	6	either	either	CC
cord-006860-a3b8hyyr	4132	7	by	by	IN
cord-006860-a3b8hyyr	4132	8	counting	count	VBG
cord-006860-a3b8hyyr	4132	9	of	of	IN
cord-006860-a3b8hyyr	4132	10	radiolabelled	radiolabelled	JJ
cord-006860-a3b8hyyr	4132	11	fibrin	fibrin	NN
cord-006860-a3b8hyyr	4132	12	degradation	degradation	NN
cord-006860-a3b8hyyr	4132	13	products	product	NNS
cord-006860-a3b8hyyr	4132	14	or	or	CC
cord-006860-a3b8hyyr	4132	15	by	by	IN
cord-006860-a3b8hyyr	4132	16	time	time	NN
cord-006860-a3b8hyyr	4132	17	of	of	IN
cord-006860-a3b8hyyr	4132	18	total	total	JJ
cord-006860-a3b8hyyr	4132	19	lysis	lysis	NN
cord-006860-a3b8hyyr	4132	20	.	.	.
cord-006860-a3b8hyyr	4133	1	Obtained	obtain	VBN
cord-006860-a3b8hyyr	4133	2	kinetic	kinetic	JJ
cord-006860-a3b8hyyr	4133	3	parameters	parameter	NNS
cord-006860-a3b8hyyr	4133	4	of	of	IN
cord-006860-a3b8hyyr	4133	5	this	this	DT
cord-006860-a3b8hyyr	4133	6	reaction	reaction	NN
cord-006860-a3b8hyyr	4133	7	:	:	:
cord-006860-a3b8hyyr	4133	8	kest=99.4	kest=99.4	CD
cord-006860-a3b8hyyr	4133	9	rain	rain	NN
cord-006860-a3b8hyyr	4133	10	-1	-1	NN
cord-006860-a3b8hyyr	4133	11	,	,	,
cord-006860-a3b8hyyr	4134	1	KM	km	NN
cord-006860-a3b8hyyr	4134	2	=	=	SYM
cord-006860-a3b8hyyr	4134	3	I.9	i.9	NN
cord-006860-a3b8hyyr	4134	4	~tM	~tM	NFP
cord-006860-a3b8hyyr	4135	1	(	(	-LRB-
cord-006860-a3b8hyyr	4135	2	plasmin	plasmin	VBP
cord-006860-a3b8hyyr	4135	3	inside	inside	IN
cord-006860-a3b8hyyr	4135	4	clot	clot	NN
cord-006860-a3b8hyyr	4135	5	)	)	-RRB-
cord-006860-a3b8hyyr	4135	6	;	;	:
cord-006860-a3b8hyyr	4135	7	kcat	kcat	NNP
cord-006860-a3b8hyyr	4135	8	=	=	SYM
cord-006860-a3b8hyyr	4135	9	l.36	l.36	NN
cord-006860-a3b8hyyr	4135	10	rain	rain	NN
cord-006860-a3b8hyyr	4136	1	-1	-1	NNP
cord-006860-a3b8hyyr	4136	2	,	,	,
cord-006860-a3b8hyyr	4136	3	KM	KM	NNP
cord-006860-a3b8hyyr	4136	4	=	=	SYM
cord-006860-a3b8hyyr	4136	5	I.3	I.3	NNP
cord-006860-a3b8hyyr	4136	6	lzM	lzM	NNP
cord-006860-a3b8hyyr	4136	7	(	(	-LRB-
cord-006860-a3b8hyyr	4136	8	plasmin	plasmin	NNP
cord-006860-a3b8hyyr	4136	9	outside	outside	IN
cord-006860-a3b8hyyr	4136	10	clot	clot	NN
cord-006860-a3b8hyyr	4136	11	)	)	-RRB-
cord-006860-a3b8hyyr	4136	12	.	.	.
cord-006860-a3b8hyyr	4137	1	This	this	DT
cord-006860-a3b8hyyr	4137	2	data	datum	NNS
cord-006860-a3b8hyyr	4137	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	4137	4	that	that	IN
cord-006860-a3b8hyyr	4137	5	eatalytie	eatalytie	NN
cord-006860-a3b8hyyr	4137	6	efficiency	efficiency	NN
cord-006860-a3b8hyyr	4137	7	of	of	IN
cord-006860-a3b8hyyr	4137	8	plasmin	plasmin	NN
cord-006860-a3b8hyyr	4137	9	from	from	IN
cord-006860-a3b8hyyr	4137	10	inside	inside	IN
cord-006860-a3b8hyyr	4137	11	the	the	DT
cord-006860-a3b8hyyr	4137	12	clot	clot	NN
cord-006860-a3b8hyyr	4137	13	is	be	VBZ
cord-006860-a3b8hyyr	4137	14	50-fold	50-fold	CD
cord-006860-a3b8hyyr	4137	15	higher	high	JJR
cord-006860-a3b8hyyr	4137	16	than	than	IN
cord-006860-a3b8hyyr	4137	17	from	from	IN
cord-006860-a3b8hyyr	4137	18	outside	outside	RB
cord-006860-a3b8hyyr	4137	19	as	as	IN
cord-006860-a3b8hyyr	4137	20	measured	measure	VBN
cord-006860-a3b8hyyr	4137	21	from	from	IN
cord-006860-a3b8hyyr	4137	22	kcat	kcat	NNP
cord-006860-a3b8hyyr	4137	23	/	/	SYM
cord-006860-a3b8hyyr	4137	24	KM	KM	NNP
cord-006860-a3b8hyyr	4137	25	.	.	.
cord-006860-a3b8hyyr	4138	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	4138	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	4138	3	studied	study	VBD
cord-006860-a3b8hyyr	4138	4	plasma	plasma	NN
cord-006860-a3b8hyyr	4138	5	clot	clot	NN
cord-006860-a3b8hyyr	4138	6	(	(	-LRB-
cord-006860-a3b8hyyr	4138	7	0.25	0.25	CD
cord-006860-a3b8hyyr	4138	8	ml	ml	NN
cord-006860-a3b8hyyr	4138	9	)	)	-RRB-
cord-006860-a3b8hyyr	4138	10	lysis	lysis	NN
cord-006860-a3b8hyyr	4138	11	in	in	IN
cord-006860-a3b8hyyr	4138	12	original	original	JJ
cord-006860-a3b8hyyr	4138	13	plasma	plasma	NN
cord-006860-a3b8hyyr	4138	14	(	(	-LRB-
cord-006860-a3b8hyyr	4138	15	3	3	CD
cord-006860-a3b8hyyr	4138	16	ml	ml	NN
cord-006860-a3b8hyyr	4138	17	)	)	-RRB-
cord-006860-a3b8hyyr	4138	18	containing	contain	VBG
cord-006860-a3b8hyyr	4138	19	SK	SK	NNP
cord-006860-a3b8hyyr	4138	20	(	(	-LRB-
cord-006860-a3b8hyyr	4138	21	5	5	CD
cord-006860-a3b8hyyr	4138	22	-	-	SYM
cord-006860-a3b8hyyr	4138	23	100	100	CD
cord-006860-a3b8hyyr	4138	24	nM	nM	NNP
cord-006860-a3b8hyyr	4138	25	)	)	-RRB-
cord-006860-a3b8hyyr	4138	26	and	and	CC
cord-006860-a3b8hyyr	4138	27	seu	seu	NNP
cord-006860-a3b8hyyr	4138	28	-	-	HYPH
cord-006860-a3b8hyyr	4138	29	PA	PA	NNP
cord-006860-a3b8hyyr	4138	30	(	(	-LRB-
cord-006860-a3b8hyyr	4138	31	5	5	CD
cord-006860-a3b8hyyr	4138	32	-	-	SYM
cord-006860-a3b8hyyr	4138	33	100	100	CD
cord-006860-a3b8hyyr	4138	34	riM	rim	CD
cord-006860-a3b8hyyr	4138	35	)	)	-RRB-
cord-006860-a3b8hyyr	4138	36	in	in	IN
cord-006860-a3b8hyyr	4138	37	the	the	DT
cord-006860-a3b8hyyr	4138	38	final	final	JJ
cord-006860-a3b8hyyr	4138	39	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4138	40	from	from	IN
cord-006860-a3b8hyyr	4138	41	inside	inside	IN
cord-006860-a3b8hyyr	4138	42	or	or	CC
cord-006860-a3b8hyyr	4138	43	outside	outside	IN
cord-006860-a3b8hyyr	4138	44	the	the	DT
cord-006860-a3b8hyyr	4138	45	clot	clot	NN
cord-006860-a3b8hyyr	4138	46	.	.	.
cord-006860-a3b8hyyr	4139	1	The	the	DT
cord-006860-a3b8hyyr	4139	2	results	result	NNS
cord-006860-a3b8hyyr	4139	3	are	be	VBP
cord-006860-a3b8hyyr	4139	4	presented	present	VBN
cord-006860-a3b8hyyr	4139	5	in	in	IN
cord-006860-a3b8hyyr	4139	6	the	the	DT
cord-006860-a3b8hyyr	4139	7	The	the	DT
cord-006860-a3b8hyyr	4139	8	similar	similar	JJ
cord-006860-a3b8hyyr	4139	9	results	result	NNS
cord-006860-a3b8hyyr	4139	10	have	have	VBP
cord-006860-a3b8hyyr	4139	11	been	be	VBN
cord-006860-a3b8hyyr	4139	12	got	get	VBN
cord-006860-a3b8hyyr	4139	13	when	when	WRB
cord-006860-a3b8hyyr	4139	14	the	the	DT
cord-006860-a3b8hyyr	4139	15	fibrin	fibrin	NN
cord-006860-a3b8hyyr	4139	16	clots	clot	NNS
cord-006860-a3b8hyyr	4139	17	were	be	VBD
cord-006860-a3b8hyyr	4139	18	formed	form	VBN
cord-006860-a3b8hyyr	4139	19	with	with	IN
cord-006860-a3b8hyyr	4139	20	batroxobin	batroxobin	NNP
cord-006860-a3b8hyyr	4139	21	instead	instead	RB
cord-006860-a3b8hyyr	4139	22	of	of	IN
cord-006860-a3b8hyyr	4139	23	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4139	24	.	.	.
cord-006860-a3b8hyyr	4140	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	4140	2	may	may	MD
cord-006860-a3b8hyyr	4140	3	be	be	VB
cord-006860-a3b8hyyr	4140	4	concluded	conclude	VBN
cord-006860-a3b8hyyr	4140	5	that	that	IN
cord-006860-a3b8hyyr	4140	6	fibfinolysis	fibfinolysis	NN
cord-006860-a3b8hyyr	4140	7	is	be	VBZ
cord-006860-a3b8hyyr	4140	8	a	a	DT
cord-006860-a3b8hyyr	4140	9	surface	surface	NN
cord-006860-a3b8hyyr	4140	10	-	-	HYPH
cord-006860-a3b8hyyr	4140	11	dependent	dependent	JJ
cord-006860-a3b8hyyr	4140	12	process	process	NN
cord-006860-a3b8hyyr	4140	13	.	.	.
cord-006860-a3b8hyyr	4141	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	4141	2	's	be	VBZ
cord-006860-a3b8hyyr	4141	3	likely	likely	JJ
cord-006860-a3b8hyyr	4141	4	that	that	IN
cord-006860-a3b8hyyr	4141	5	the	the	DT
cord-006860-a3b8hyyr	4141	6	higher	high	JJR
cord-006860-a3b8hyyr	4141	7	level	level	NN
cord-006860-a3b8hyyr	4141	8	of	of	IN
cord-006860-a3b8hyyr	4141	9	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4141	10	activators	activator	NNS
cord-006860-a3b8hyyr	4141	11	in	in	IN
cord-006860-a3b8hyyr	4141	12	blood	blood	NN
cord-006860-a3b8hyyr	4141	13	would	would	MD
cord-006860-a3b8hyyr	4141	14	prevent	prevent	VB
cord-006860-a3b8hyyr	4141	15	thrombus	thrombus	NN
cord-006860-a3b8hyyr	4141	16	formation	formation	NN
cord-006860-a3b8hyyr	4141	17	,	,	,
cord-006860-a3b8hyyr	4141	18	while	while	IN
cord-006860-a3b8hyyr	4141	19	physiological	physiological	JJ
cord-006860-a3b8hyyr	4141	20	clots	clot	NNS
cord-006860-a3b8hyyr	4141	21	would	would	MD
cord-006860-a3b8hyyr	4141	22	stay	stay	VB
cord-006860-a3b8hyyr	4141	23	resistant	resistant	JJ
cord-006860-a3b8hyyr	4141	24	.	.	.
cord-006860-a3b8hyyr	4142	1	For	for	IN
cord-006860-a3b8hyyr	4142	2	the	the	DT
cord-006860-a3b8hyyr	4142	3	improvement	improvement	NN
cord-006860-a3b8hyyr	4142	4	of	of	IN
cord-006860-a3b8hyyr	4142	5	the	the	DT
cord-006860-a3b8hyyr	4142	6	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	4142	7	therapy	therapy	NN
cord-006860-a3b8hyyr	4142	8	in	in	IN
cord-006860-a3b8hyyr	4142	9	children	child	NNS
cord-006860-a3b8hyyr	4142	10	more	more	RBR
cord-006860-a3b8hyyr	4142	11	clinical	clinical	JJ
cord-006860-a3b8hyyr	4142	12	data	datum	NNS
cord-006860-a3b8hyyr	4142	13	are	be	VBP
cord-006860-a3b8hyyr	4142	14	needed	need	VBN
cord-006860-a3b8hyyr	4142	15	.	.	.
cord-006860-a3b8hyyr	4143	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	4143	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	4143	3	report	report	VBP
cord-006860-a3b8hyyr	4143	4	on	on	IN
cord-006860-a3b8hyyr	4143	5	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4143	6	experiences	experience	NNS
cord-006860-a3b8hyyr	4143	7	with	with	IN
cord-006860-a3b8hyyr	4143	8	rt	rt	NNP
cord-006860-a3b8hyyr	4143	9	-	-	HYPH
cord-006860-a3b8hyyr	4143	10	PA	PA	NNP
cord-006860-a3b8hyyr	4143	11	presenting	present	VBG
cord-006860-a3b8hyyr	4143	12	the	the	DT
cord-006860-a3b8hyyr	4143	13	clinical	clinical	JJ
cord-006860-a3b8hyyr	4143	14	course	course	NN
cord-006860-a3b8hyyr	4143	15	in	in	IN
cord-006860-a3b8hyyr	4143	16	11	11	CD
cord-006860-a3b8hyyr	4143	17	patients	patient	NNS
cord-006860-a3b8hyyr	4143	18	(	(	-LRB-
cord-006860-a3b8hyyr	4143	19	age	age	NN
cord-006860-a3b8hyyr	4143	20	range	range	NN
cord-006860-a3b8hyyr	4143	21	:	:	:
cord-006860-a3b8hyyr	4143	22	7	7	CD
cord-006860-a3b8hyyr	4143	23	days	day	NNS
cord-006860-a3b8hyyr	4143	24	to	to	IN
cord-006860-a3b8hyyr	4143	25	16	16	CD
cord-006860-a3b8hyyr	4143	26	years	year	NNS
cord-006860-a3b8hyyr	4143	27	)	)	-RRB-
cord-006860-a3b8hyyr	4143	28	with	with	IN
cord-006860-a3b8hyyr	4143	29	venous	venous	JJ
cord-006860-a3b8hyyr	4143	30	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4143	31	(	(	-LRB-
cord-006860-a3b8hyyr	4143	32	n=9	n=9	NN
cord-006860-a3b8hyyr	4143	33	)	)	-RRB-
cord-006860-a3b8hyyr	4143	34	and	and	CC
cord-006860-a3b8hyyr	4143	35	purpura	purpura	NNP
cord-006860-a3b8hyyr	4143	36	fulminans	fulminans	NNP
cord-006860-a3b8hyyr	4143	37	by	by	IN
cord-006860-a3b8hyyr	4143	38	meningococcosis	meningococcosis	NNP
cord-006860-a3b8hyyr	4143	39	(	(	-LRB-
cord-006860-a3b8hyyr	4143	40	n=2	n=2	NNP
cord-006860-a3b8hyyr	4143	41	)	)	-RRB-
cord-006860-a3b8hyyr	4143	42	.	.	.
cord-006860-a3b8hyyr	4144	1	The	the	DT
cord-006860-a3b8hyyr	4144	2	patients	patient	NNS
cord-006860-a3b8hyyr	4144	3	were	be	VBD
cord-006860-a3b8hyyr	4144	4	treated	treat	VBN
cord-006860-a3b8hyyr	4144	5	with	with	IN
cord-006860-a3b8hyyr	4144	6	rt	rt	NNP
cord-006860-a3b8hyyr	4144	7	-	-	HYPH
cord-006860-a3b8hyyr	4144	8	PA	PA	NNP
cord-006860-a3b8hyyr	4144	9	(	(	-LRB-
cord-006860-a3b8hyyr	4144	10	Actilyse	Actilyse	NNP
cord-006860-a3b8hyyr	4144	11	R	r	NN
cord-006860-a3b8hyyr	4144	12	)	)	-RRB-
cord-006860-a3b8hyyr	4144	13	for	for	IN
cord-006860-a3b8hyyr	4144	14	10,5	10,5	CD
cord-006860-a3b8hyyr	4144	15	hours	hour	NNS
cord-006860-a3b8hyyr	4144	16	to	to	IN
cord-006860-a3b8hyyr	4144	17	13	13	CD
cord-006860-a3b8hyyr	4144	18	days	day	NNS
cord-006860-a3b8hyyr	4144	19	.	.	.
cord-006860-a3b8hyyr	4145	1	The	the	DT
cord-006860-a3b8hyyr	4145	2	venous	venous	JJ
cord-006860-a3b8hyyr	4145	3	thromboses	thrombose	NNS
cord-006860-a3b8hyyr	4145	4	were	be	VBD
cord-006860-a3b8hyyr	4145	5	localized	localize	VBN
cord-006860-a3b8hyyr	4145	6	in	in	IN
cord-006860-a3b8hyyr	4145	7	lilac	lilac	JJ
cord-006860-a3b8hyyr	4145	8	/	/	SYM
cord-006860-a3b8hyyr	4145	9	femoral	femoral	JJ
cord-006860-a3b8hyyr	4145	10	veins	vein	NNS
cord-006860-a3b8hyyr	4145	11	(	(	-LRB-
cord-006860-a3b8hyyr	4145	12	n=4	n=4	NNP
cord-006860-a3b8hyyr	4145	13	)	)	-RRB-
cord-006860-a3b8hyyr	4145	14	,	,	,
cord-006860-a3b8hyyr	4145	15	brachiocephalic	brachiocephalic	NNP
cord-006860-a3b8hyyr	4145	16	/	/	SYM
cord-006860-a3b8hyyr	4145	17	jugular	jugular	NN
cord-006860-a3b8hyyr	4145	18	/	/	SYM
cord-006860-a3b8hyyr	4145	19	subclavian	subclavian	JJ
cord-006860-a3b8hyyr	4145	20	veins	vein	NNS
cord-006860-a3b8hyyr	4145	21	(	(	-LRB-
cord-006860-a3b8hyyr	4145	22	n=3	n=3	NN
cord-006860-a3b8hyyr	4145	23	)	)	-RRB-
cord-006860-a3b8hyyr	4145	24	and	and	CC
cord-006860-a3b8hyyr	4145	25	the	the	DT
cord-006860-a3b8hyyr	4145	26	cava	cava	NNP
cord-006860-a3b8hyyr	4145	27	superior	superior	JJ
cord-006860-a3b8hyyr	4145	28	vein	vein	NNP
cord-006860-a3b8hyyr	4145	29	(	(	-LRB-
cord-006860-a3b8hyyr	4145	30	n	n	NN
cord-006860-a3b8hyyr	4145	31	=	=	NN
cord-006860-a3b8hyyr	4145	32	l	l	NN
cord-006860-a3b8hyyr	4145	33	)	)	-RRB-
cord-006860-a3b8hyyr	4145	34	.	.	.
cord-006860-a3b8hyyr	4146	1	Central	central	JJ
cord-006860-a3b8hyyr	4146	2	venous	venous	JJ
cord-006860-a3b8hyyr	4146	3	catheters	catheter	NNS
cord-006860-a3b8hyyr	4146	4	were	be	VBD
cord-006860-a3b8hyyr	4146	5	causative	causative	JJ
cord-006860-a3b8hyyr	4146	6	in	in	IN
cord-006860-a3b8hyyr	4146	7	2	2	CD
cord-006860-a3b8hyyr	4146	8	cases	case	NNS
cord-006860-a3b8hyyr	4146	9	.	.	.
cord-006860-a3b8hyyr	4147	1	The	the	DT
cord-006860-a3b8hyyr	4147	2	dosage	dosage	NN
cord-006860-a3b8hyyr	4147	3	range	range	NN
cord-006860-a3b8hyyr	4147	4	was	be	VBD
cord-006860-a3b8hyyr	4147	5	between	between	IN
cord-006860-a3b8hyyr	4147	6	0.2	0.2	CD
cord-006860-a3b8hyyr	4147	7	to	to	TO
cord-006860-a3b8hyyr	4147	8	0.5	0.5	CD
cord-006860-a3b8hyyr	4147	9	mg	mg	NNP
cord-006860-a3b8hyyr	4147	10	/	/	SYM
cord-006860-a3b8hyyr	4147	11	kg	kg	NNS
cord-006860-a3b8hyyr	4147	12	for	for	IN
cord-006860-a3b8hyyr	4147	13	the	the	DT
cord-006860-a3b8hyyr	4147	14	initial	initial	JJ
cord-006860-a3b8hyyr	4147	15	dose	dose	NN
cord-006860-a3b8hyyr	4147	16	and	and	CC
cord-006860-a3b8hyyr	4147	17	0.8	0.8	CD
cord-006860-a3b8hyyr	4147	18	to	to	TO
cord-006860-a3b8hyyr	4147	19	2.0	2.0	CD
cord-006860-a3b8hyyr	4147	20	mg	mg	NNP
cord-006860-a3b8hyyr	4147	21	/	/	SYM
cord-006860-a3b8hyyr	4147	22	kg	kg	NNP
cord-006860-a3b8hyyr	4147	23	/	/	SYM
cord-006860-a3b8hyyr	4147	24	d	d	XX
cord-006860-a3b8hyyr	4147	25	for	for	IN
cord-006860-a3b8hyyr	4147	26	the	the	DT
cord-006860-a3b8hyyr	4147	27	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	4147	28	continous	continous	JJ
cord-006860-a3b8hyyr	4147	29	infusion	infusion	NN
cord-006860-a3b8hyyr	4147	30	.	.	.
cord-006860-a3b8hyyr	4148	1	Ten	ten	CD
cord-006860-a3b8hyyr	4148	2	patients	patient	NNS
cord-006860-a3b8hyyr	4148	3	received	receive	VBD
cord-006860-a3b8hyyr	4148	4	simultaneously	simultaneously	RB
cord-006860-a3b8hyyr	4148	5	heparin	heparin	JJ
cord-006860-a3b8hyyr	4148	6	.	.	.
cord-006860-a3b8hyyr	4149	1	Complete	complete	JJ
cord-006860-a3b8hyyr	4149	2	clot	clot	NN
cord-006860-a3b8hyyr	4149	3	dissolution	dissolution	NN
cord-006860-a3b8hyyr	4149	4	occured	occur	VBD
cord-006860-a3b8hyyr	4149	5	in	in	IN
cord-006860-a3b8hyyr	4149	6	6	6	CD
cord-006860-a3b8hyyr	4149	7	cases	case	NNS
cord-006860-a3b8hyyr	4149	8	,	,	,
cord-006860-a3b8hyyr	4149	9	partial	partial	JJ
cord-006860-a3b8hyyr	4149	10	clot	clot	NN
cord-006860-a3b8hyyr	4149	11	dissolution	dissolution	NN
cord-006860-a3b8hyyr	4149	12	in	in	IN
cord-006860-a3b8hyyr	4149	13	1	1	CD
cord-006860-a3b8hyyr	4149	14	patient	patient	NN
cord-006860-a3b8hyyr	4149	15	.	.	.
cord-006860-a3b8hyyr	4150	1	In	in	IN
cord-006860-a3b8hyyr	4150	2	4	4	CD
cord-006860-a3b8hyyr	4150	3	patients	patient	NNS
cord-006860-a3b8hyyr	4150	4	with	with	IN
cord-006860-a3b8hyyr	4150	5	a	a	DT
cord-006860-a3b8hyyr	4150	6	history	history	NN
cord-006860-a3b8hyyr	4150	7	of	of	IN
cord-006860-a3b8hyyr	4150	8	the	the	DT
cord-006860-a3b8hyyr	4150	9	first	first	JJ
cord-006860-a3b8hyyr	4150	10	clinical	clinical	JJ
cord-006860-a3b8hyyr	4150	11	signs	sign	NNS
cord-006860-a3b8hyyr	4150	12	of	of	IN
cord-006860-a3b8hyyr	4150	13	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4150	14	of	of	IN
cord-006860-a3b8hyyr	4150	15	3	3	CD
cord-006860-a3b8hyyr	4150	16	weeks	week	NNS
cord-006860-a3b8hyyr	4150	17	or	or	CC
cord-006860-a3b8hyyr	4150	18	more	more	JJR
cord-006860-a3b8hyyr	4150	19	the	the	DT
cord-006860-a3b8hyyr	4150	20	lysis	lysis	NN
cord-006860-a3b8hyyr	4150	21	was	be	VBD
cord-006860-a3b8hyyr	4150	22	not	not	RB
cord-006860-a3b8hyyr	4150	23	successful	successful	JJ
cord-006860-a3b8hyyr	4150	24	.	.	.
cord-006860-a3b8hyyr	4151	1	Concerning	concern	VBG
cord-006860-a3b8hyyr	4151	2	the	the	DT
cord-006860-a3b8hyyr	4151	3	side	side	NN
cord-006860-a3b8hyyr	4151	4	effects	effect	NNS
cord-006860-a3b8hyyr	4151	5	only	only	RB
cord-006860-a3b8hyyr	4151	6	small	small	JJ
cord-006860-a3b8hyyr	4151	7	bleeding	bleeding	NN
cord-006860-a3b8hyyr	4151	8	episodes	episode	NNS
cord-006860-a3b8hyyr	4151	9	on	on	IN
cord-006860-a3b8hyyr	4151	10	former	former	JJ
cord-006860-a3b8hyyr	4151	11	venipuncture	venipuncture	NN
cord-006860-a3b8hyyr	4151	12	sites	site	NNS
cord-006860-a3b8hyyr	4151	13	were	be	VBD
cord-006860-a3b8hyyr	4151	14	observed	observe	VBN
cord-006860-a3b8hyyr	4151	15	in	in	IN
cord-006860-a3b8hyyr	4151	16	5	5	CD
cord-006860-a3b8hyyr	4151	17	patients	patient	NNS
cord-006860-a3b8hyyr	4151	18	.	.	.
cord-006860-a3b8hyyr	4152	1	Systemic	systemic	JJ
cord-006860-a3b8hyyr	4152	2	effects	effect	NNS
cord-006860-a3b8hyyr	4152	3	such	such	JJ
cord-006860-a3b8hyyr	4152	4	as	as	IN
cord-006860-a3b8hyyr	4152	5	the	the	DT
cord-006860-a3b8hyyr	4152	6	decrease	decrease	NN
cord-006860-a3b8hyyr	4152	7	of	of	IN
cord-006860-a3b8hyyr	4152	8	the	the	DT
cord-006860-a3b8hyyr	4152	9	plasma	plasma	NN
cord-006860-a3b8hyyr	4152	10	flbrinogen	flbrinogen	NN
cord-006860-a3b8hyyr	4152	11	concentration	concentration	NN
cord-006860-a3b8hyyr	4152	12	were	be	VBD
cord-006860-a3b8hyyr	4152	13	rare	rare	JJ
cord-006860-a3b8hyyr	4152	14	too	too	RB
cord-006860-a3b8hyyr	4152	15	.	.	.
cord-006860-a3b8hyyr	4153	1	In	in	IN
cord-006860-a3b8hyyr	4153	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	4153	3	,	,	,
cord-006860-a3b8hyyr	4153	4	the	the	DT
cord-006860-a3b8hyyr	4153	5	thrombelysis	thrombelysis	NN
cord-006860-a3b8hyyr	4153	6	with	with	IN
cord-006860-a3b8hyyr	4153	7	rt	rt	NNP
cord-006860-a3b8hyyr	4153	8	-	-	HYPH
cord-006860-a3b8hyyr	4153	9	PA	PA	NNP
cord-006860-a3b8hyyr	4153	10	presents	present	VBZ
cord-006860-a3b8hyyr	4153	11	an	an	DT
cord-006860-a3b8hyyr	4153	12	effective	effective	JJ
cord-006860-a3b8hyyr	4153	13	and	and	CC
cord-006860-a3b8hyyr	4153	14	safe	safe	JJ
cord-006860-a3b8hyyr	4153	15	therapy	therapy	NN
cord-006860-a3b8hyyr	4153	16	in	in	IN
cord-006860-a3b8hyyr	4153	17	children	child	NNS
cord-006860-a3b8hyyr	4153	18	at	at	IN
cord-006860-a3b8hyyr	4153	19	:	:	:
cord-006860-a3b8hyyr	4153	20	the	the	DT
cord-006860-a3b8hyyr	4153	21	rt	rt	NNP
cord-006860-a3b8hyyr	4153	22	-	-	HYPH
cord-006860-a3b8hyyr	4153	23	PA	PA	NNP
cord-006860-a3b8hyyr	4153	24	dosage	dosage	NN
cord-006860-a3b8hyyr	4153	25	used	use	VBN
cord-006860-a3b8hyyr	4153	26	.	.	.
cord-006860-a3b8hyyr	4154	1	In	in	IN
cord-006860-a3b8hyyr	4154	2	case	case	NN
cord-006860-a3b8hyyr	4154	3	of	of	IN
cord-006860-a3b8hyyr	4154	4	a	a	DT
cord-006860-a3b8hyyr	4154	5	history	history	NN
cord-006860-a3b8hyyr	4154	6	of	of	IN
cord-006860-a3b8hyyr	4154	7	the	the	DT
cord-006860-a3b8hyyr	4154	8	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	4154	9	event	event	NN
cord-006860-a3b8hyyr	4154	10	of	of	IN
cord-006860-a3b8hyyr	4154	11	more	more	JJR
cord-006860-a3b8hyyr	4154	12	than	than	IN
cord-006860-a3b8hyyr	4154	13	3	3	CD
cord-006860-a3b8hyyr	4154	14	weeks	week	NNS
cord-006860-a3b8hyyr	4154	15	a	a	DT
cord-006860-a3b8hyyr	4154	16	thrombotytic	thrombotytic	JJ
cord-006860-a3b8hyyr	4154	17	therapy	therapy	NN
cord-006860-a3b8hyyr	4154	18	should	should	MD
cord-006860-a3b8hyyr	4154	19	not	not	RB
cord-006860-a3b8hyyr	4154	20	be	be	VB
cord-006860-a3b8hyyr	4154	21	carried	carry	VBN
cord-006860-a3b8hyyr	4154	22	out	out	RP
cord-006860-a3b8hyyr	4154	23	.	.	.
cord-006860-a3b8hyyr	4155	1	D.Dimer	D.Dimer	NNP
cord-006860-a3b8hyyr	4155	2	is	be	VBZ
cord-006860-a3b8hyyr	4155	3	widely	widely	RB
cord-006860-a3b8hyyr	4155	4	used	use	VBN
cord-006860-a3b8hyyr	4155	5	in	in	IN
cord-006860-a3b8hyyr	4155	6	clinical	clinical	JJ
cord-006860-a3b8hyyr	4155	7	situations	situation	NNS
cord-006860-a3b8hyyr	4155	8	associated	associate	VBN
cord-006860-a3b8hyyr	4155	9	with	with	IN
cord-006860-a3b8hyyr	4155	10	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	4155	11	diseases	disease	NNS
cord-006860-a3b8hyyr	4155	12	.	.	.
cord-006860-a3b8hyyr	4156	1	The	the	DT
cord-006860-a3b8hyyr	4156	2	most	most	RBS
cord-006860-a3b8hyyr	4156	3	popular	popular	JJ
cord-006860-a3b8hyyr	4156	4	application	application	NN
cord-006860-a3b8hyyr	4156	5	is	be	VBZ
cord-006860-a3b8hyyr	4156	6	the	the	DT
cord-006860-a3b8hyyr	4156	7	exclusion	exclusion	NN
cord-006860-a3b8hyyr	4156	8	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	4156	9	of	of	IN
cord-006860-a3b8hyyr	4156	10	deep	deep	JJ
cord-006860-a3b8hyyr	4156	11	-	-	HYPH
cord-006860-a3b8hyyr	4156	12	veinthrombosis	veinthrombosis	NN
cord-006860-a3b8hyyr	4156	13	and	and	CC
cord-006860-a3b8hyyr	4156	14	pulmonary	pulmonary	NN
cord-006860-a3b8hyyr	4156	15	-	-	HYPH
cord-006860-a3b8hyyr	4156	16	embolism	embolism	NN
cord-006860-a3b8hyyr	4156	17	and	and	CC
cord-006860-a3b8hyyr	4156	18	the	the	DT
cord-006860-a3b8hyyr	4156	19	assay	assay	NN
cord-006860-a3b8hyyr	4156	20	is	be	VBZ
cord-006860-a3b8hyyr	4156	21	performed	perform	VBN
cord-006860-a3b8hyyr	4156	22	in	in	IN
cord-006860-a3b8hyyr	4156	23	emergency	emergency	NN
cord-006860-a3b8hyyr	4156	24	.	.	.
cord-006860-a3b8hyyr	4157	1	D.Dimer	D.Dimer	NNP
cord-006860-a3b8hyyr	4157	2	is	be	VBZ
cord-006860-a3b8hyyr	4157	3	also	also	RB
cord-006860-a3b8hyyr	4157	4	frequently	frequently	RB
cord-006860-a3b8hyyr	4157	5	measured	measure	VBN
cord-006860-a3b8hyyr	4157	6	for	for	IN
cord-006860-a3b8hyyr	4157	7	evaluating	evaluate	VBG
cord-006860-a3b8hyyr	4157	8	the	the	DT
cord-006860-a3b8hyyr	4157	9	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	4157	10	risk	risk	NN
cord-006860-a3b8hyyr	4157	11	in	in	IN
cord-006860-a3b8hyyr	4157	12	the	the	DT
cord-006860-a3b8hyyr	4157	13	post	post	JJ
cord-006860-a3b8hyyr	4157	14	-	-	JJ
cord-006860-a3b8hyyr	4157	15	operative	operative	JJ
cord-006860-a3b8hyyr	4157	16	period	period	NN
cord-006860-a3b8hyyr	4157	17	.	.	.
cord-006860-a3b8hyyr	4158	1	Quantitative	quantitative	JJ
cord-006860-a3b8hyyr	4158	2	,	,	,
cord-006860-a3b8hyyr	4158	3	flexible	flexible	JJ
cord-006860-a3b8hyyr	4158	4	and	and	CC
cord-006860-a3b8hyyr	4158	5	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	4158	6	assays	assay	NNS
cord-006860-a3b8hyyr	4158	7	are	be	VBP
cord-006860-a3b8hyyr	4158	8	required	require	VBN
cord-006860-a3b8hyyr	4158	9	.	.	.
cord-006860-a3b8hyyr	4159	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4159	2	have	have	VBP
cord-006860-a3b8hyyr	4159	3	developed	develop	VBN
cord-006860-a3b8hyyr	4159	4	a	a	DT
cord-006860-a3b8hyyr	4159	5	new	new	JJ
cord-006860-a3b8hyyr	4159	6	automatic	automatic	JJ
cord-006860-a3b8hyyr	4159	7	method	method	NN
cord-006860-a3b8hyyr	4159	8	which	which	WDT
cord-006860-a3b8hyyr	4159	9	works	work	VBZ
cord-006860-a3b8hyyr	4159	10	on	on	IN
cord-006860-a3b8hyyr	4159	11	the	the	DT
cord-006860-a3b8hyyr	4159	12	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4159	13	walk	walk	NN
cord-006860-a3b8hyyr	4159	14	-	-	HYPH
cord-006860-a3b8hyyr	4159	15	away	away	RP
cord-006860-a3b8hyyr	4159	16	instrument	instrument	NN
cord-006860-a3b8hyyr	4159	17	,	,	,
cord-006860-a3b8hyyr	4159	18	STA	STA	NNP
cord-006860-a3b8hyyr	4159	19	.	.	.
cord-006860-a3b8hyyr	4160	1	This	this	DT
cord-006860-a3b8hyyr	4160	2	assay	assay	NN
cord-006860-a3b8hyyr	4160	3	was	be	VBD
cord-006860-a3b8hyyr	4160	4	developed	develop	VBN
cord-006860-a3b8hyyr	4160	5	with	with	IN
cord-006860-a3b8hyyr	4160	6	two	two	CD
cord-006860-a3b8hyyr	4160	7	monocloual	monocloual	NNP
cord-006860-a3b8hyyr	4160	8	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4160	9	specific	specific	JJ
cord-006860-a3b8hyyr	4160	10	for	for	IN
cord-006860-a3b8hyyr	4160	11	D.Dimer	D.Dimer	NNP
cord-006860-a3b8hyyr	4160	12	coated	coat	VBN
cord-006860-a3b8hyyr	4160	13	on	on	IN
cord-006860-a3b8hyyr	4160	14	microlatex	microlatex	NN
cord-006860-a3b8hyyr	4160	15	particles	particle	NNS
cord-006860-a3b8hyyr	4160	16	and	and	CC
cord-006860-a3b8hyyr	4160	17	it	-PRON-	PRP
cord-006860-a3b8hyyr	4160	18	uses	use	VBZ
cord-006860-a3b8hyyr	4160	19	an	an	DT
cord-006860-a3b8hyyr	4160	20	immuno	immuno	JJ
cord-006860-a3b8hyyr	4160	21	-	-	JJ
cord-006860-a3b8hyyr	4160	22	turbidimetric	turbidimetric	JJ
cord-006860-a3b8hyyr	4160	23	technology	technology	NN
cord-006860-a3b8hyyr	4160	24	.	.	.
cord-006860-a3b8hyyr	4161	1	Absorbance	Absorbance	NNP
cord-006860-a3b8hyyr	4161	2	is	be	VBZ
cord-006860-a3b8hyyr	4161	3	measured	measure	VBN
cord-006860-a3b8hyyr	4161	4	at	at	IN
cord-006860-a3b8hyyr	4161	5	540	540	CD
cord-006860-a3b8hyyr	4161	6	nm	nm	NN
cord-006860-a3b8hyyr	4161	7	and	and	CC
cord-006860-a3b8hyyr	4161	8	is	be	VBZ
cord-006860-a3b8hyyr	4161	9	a	a	DT
cord-006860-a3b8hyyr	4161	10	direct	direct	JJ
cord-006860-a3b8hyyr	4161	11	relationship	relationship	NN
cord-006860-a3b8hyyr	4161	12	of	of	IN
cord-006860-a3b8hyyr	4161	13	D.Dimer	D.Dimer	NNP
cord-006860-a3b8hyyr	4161	14	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4161	15	.	.	.
cord-006860-a3b8hyyr	4162	1	The	the	DT
cord-006860-a3b8hyyr	4162	2	assay	assay	NN
cord-006860-a3b8hyyr	4162	3	works	work	VBZ
cord-006860-a3b8hyyr	4162	4	with	with	IN
cord-006860-a3b8hyyr	4162	5	50	50	CD
cord-006860-a3b8hyyr	4162	6	~tl	~tl	JJ
cord-006860-a3b8hyyr	4162	7	undiluted	undiluted	JJ
cord-006860-a3b8hyyr	4162	8	plasma	plasma	NN
cord-006860-a3b8hyyr	4162	9	and	and	CC
cord-006860-a3b8hyyr	4162	10	is	be	VBZ
cord-006860-a3b8hyyr	4162	11	performed	perform	VBN
cord-006860-a3b8hyyr	4162	12	in	in	IN
cord-006860-a3b8hyyr	4162	13	less	less	JJR
cord-006860-a3b8hyyr	4162	14	than	than	IN
cord-006860-a3b8hyyr	4162	15	10	10	CD
cord-006860-a3b8hyyr	4162	16	minutes	minute	NNS
cord-006860-a3b8hyyr	4162	17	.	.	.
cord-006860-a3b8hyyr	4163	1	The	the	DT
cord-006860-a3b8hyyr	4163	2	dynamic	dynamic	JJ
cord-006860-a3b8hyyr	4163	3	range	range	NN
cord-006860-a3b8hyyr	4163	4	is	be	VBZ
cord-006860-a3b8hyyr	4163	5	from	from	IN
cord-006860-a3b8hyyr	4163	6	0.2	0.2	CD
cord-006860-a3b8hyyr	4163	7	to	to	IN
cord-006860-a3b8hyyr	4163	8	16	16	CD
cord-006860-a3b8hyyr	4164	1	[	[	-LRB-
cord-006860-a3b8hyyr	4164	2	~g	~g	NNP
cord-006860-a3b8hyyr	4164	3	/	/	SYM
cord-006860-a3b8hyyr	4164	4	ml	ml	NN
cord-006860-a3b8hyyr	4164	5	and	and	CC
cord-006860-a3b8hyyr	4164	6	no	no	DT
cord-006860-a3b8hyyr	4164	7	prozone	prozone	NN
cord-006860-a3b8hyyr	4164	8	effect	effect	NN
cord-006860-a3b8hyyr	4164	9	is	be	VBZ
cord-006860-a3b8hyyr	4164	10	observed	observe	VBN
cord-006860-a3b8hyyr	4164	11	up	up	RP
cord-006860-a3b8hyyr	4164	12	to	to	IN
cord-006860-a3b8hyyr	4164	13	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4164	14	higher	high	JJR
cord-006860-a3b8hyyr	4164	15	than	than	IN
cord-006860-a3b8hyyr	4164	16	100	100	CD
cord-006860-a3b8hyyr	4165	1	~tg	~tg	NNP
cord-006860-a3b8hyyr	4165	2	/	/	SYM
cord-006860-a3b8hyyr	4165	3	ml	ml	NN
cord-006860-a3b8hyyr	4165	4	.	.	.
cord-006860-a3b8hyyr	4166	1	The	the	DT
cord-006860-a3b8hyyr	4166	2	detection	detection	NN
cord-006860-a3b8hyyr	4166	3	threshold	threshold	NN
cord-006860-a3b8hyyr	4166	4	is	be	VBZ
cord-006860-a3b8hyyr	4166	5	of	of	IN
cord-006860-a3b8hyyr	4166	6	0.2	0.2	CD
cord-006860-a3b8hyyr	4166	7	[	[	-LRB-
cord-006860-a3b8hyyr	4166	8	lg	lg	NNP
cord-006860-a3b8hyyr	4166	9	/	/	SYM
cord-006860-a3b8hyyr	4166	10	ml	ml	NN
cord-006860-a3b8hyyr	4166	11	.	.	.
cord-006860-a3b8hyyr	4167	1	The	the	DT
cord-006860-a3b8hyyr	4167	2	intra	intra	JJ
cord-006860-a3b8hyyr	4167	3	-	-	JJ
cord-006860-a3b8hyyr	4167	4	assay	assay	JJ
cord-006860-a3b8hyyr	4167	5	reproducibility	reproducibility	NN
cord-006860-a3b8hyyr	4167	6	is	be	VBZ
cord-006860-a3b8hyyr	4167	7	below	below	IN
cord-006860-a3b8hyyr	4167	8	5	5	CD
cord-006860-a3b8hyyr	4167	9	%	%	NN
cord-006860-a3b8hyyr	4167	10	and	and	CC
cord-006860-a3b8hyyr	4167	11	the	the	DT
cord-006860-a3b8hyyr	4167	12	inter	inter	JJ
cord-006860-a3b8hyyr	4167	13	-	-	JJ
cord-006860-a3b8hyyr	4167	14	assay	assay	JJ
cord-006860-a3b8hyyr	4167	15	reproducibility	reproducibility	NN
cord-006860-a3b8hyyr	4167	16	is	be	VBZ
cord-006860-a3b8hyyr	4167	17	below	below	IN
cord-006860-a3b8hyyr	4167	18	6	6	CD
cord-006860-a3b8hyyr	4167	19	%	%	NN
cord-006860-a3b8hyyr	4167	20	.	.	.
cord-006860-a3b8hyyr	4168	1	Recovery	recovery	NN
cord-006860-a3b8hyyr	4168	2	studies	study	NNS
cord-006860-a3b8hyyr	4168	3	of	of	IN
cord-006860-a3b8hyyr	4168	4	purified	purify	VBN
cord-006860-a3b8hyyr	4168	5	D.Dimer	D.Dimer	NNP
cord-006860-a3b8hyyr	4168	6	added	add	VBD
cord-006860-a3b8hyyr	4168	7	to	to	IN
cord-006860-a3b8hyyr	4168	8	normal	normal	JJ
cord-006860-a3b8hyyr	4168	9	plasma	plasma	NN
cord-006860-a3b8hyyr	4168	10	were	be	VBD
cord-006860-a3b8hyyr	4168	11	between	between	IN
cord-006860-a3b8hyyr	4168	12	94	94	CD
cord-006860-a3b8hyyr	4168	13	and	and	CC
cord-006860-a3b8hyyr	4168	14	105	105	CD
cord-006860-a3b8hyyr	4168	15	%	%	NN
cord-006860-a3b8hyyr	4168	16	.	.	.
cord-006860-a3b8hyyr	4169	1	No	no	DT
cord-006860-a3b8hyyr	4169	2	interference	interference	NN
cord-006860-a3b8hyyr	4169	3	of	of	IN
cord-006860-a3b8hyyr	4169	4	heparin	heparin	NN
cord-006860-a3b8hyyr	4169	5	,	,	,
cord-006860-a3b8hyyr	4169	6	bflirubine	bflirubine	NNP
cord-006860-a3b8hyyr	4169	7	,	,	,
cord-006860-a3b8hyyr	4169	8	lipids	lipid	NNS
cord-006860-a3b8hyyr	4169	9	or	or	CC
cord-006860-a3b8hyyr	4169	10	of	of	IN
cord-006860-a3b8hyyr	4169	11	rheumatoid	rheumatoid	NN
cord-006860-a3b8hyyr	4169	12	factor	factor	NN
cord-006860-a3b8hyyr	4169	13	up	up	RP
cord-006860-a3b8hyyr	4169	14	to	to	IN
cord-006860-a3b8hyyr	4169	15	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4169	16	of	of	IN
cord-006860-a3b8hyyr	4169	17	100	100	CD
cord-006860-a3b8hyyr	4169	18	U	u	NN
cord-006860-a3b8hyyr	4169	19	/	/	SYM
cord-006860-a3b8hyyr	4169	20	ml	ml	NN
cord-006860-a3b8hyyr	4169	21	is	be	VBZ
cord-006860-a3b8hyyr	4169	22	observed	observe	VBN
cord-006860-a3b8hyyr	4169	23	.	.	.
cord-006860-a3b8hyyr	4170	1	There	there	EX
cord-006860-a3b8hyyr	4170	2	is	be	VBZ
cord-006860-a3b8hyyr	4170	3	no	no	DT
cord-006860-a3b8hyyr	4170	4	effect	effect	NN
cord-006860-a3b8hyyr	4170	5	of	of	IN
cord-006860-a3b8hyyr	4170	6	high	high	JJ
cord-006860-a3b8hyyr	4170	7	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4170	8	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4170	9	(	(	-LRB-
cord-006860-a3b8hyyr	4170	10	>	>	NFP
cord-006860-a3b8hyyr	4170	11	10	10	CD
cord-006860-a3b8hyyr	4170	12	g	g	NN
cord-006860-a3b8hyyr	4170	13	/	/	SYM
cord-006860-a3b8hyyr	4170	14	l	l	NN
cord-006860-a3b8hyyr	4170	15	)	)	-RRB-
cord-006860-a3b8hyyr	4170	16	.	.	.
cord-006860-a3b8hyyr	4171	1	When	when	WRB
cord-006860-a3b8hyyr	4171	2	compared	compare	VBN
cord-006860-a3b8hyyr	4171	3	with	with	IN
cord-006860-a3b8hyyr	4171	4	conventional	conventional	JJ
cord-006860-a3b8hyyr	4171	5	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	4171	6	techniques	technique	NNS
cord-006860-a3b8hyyr	4171	7	(	(	-LRB-
cord-006860-a3b8hyyr	4171	8	Asserachrom	Asserachrom	NNP
cord-006860-a3b8hyyr	4171	9	DDi	DDi	NNS
cord-006860-a3b8hyyr	4171	10	)	)	-RRB-
cord-006860-a3b8hyyr	4171	11	,	,	,
cord-006860-a3b8hyyr	4171	12	the	the	DT
cord-006860-a3b8hyyr	4171	13	assay	assay	NN
cord-006860-a3b8hyyr	4171	14	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	4171	15	a	a	DT
cord-006860-a3b8hyyr	4171	16	correlation	correlation	NN
cord-006860-a3b8hyyr	4171	17	coefficient	coefficient	NN
cord-006860-a3b8hyyr	4171	18	of	of	IN
cord-006860-a3b8hyyr	4171	19	0.97	0.97	CD
cord-006860-a3b8hyyr	4171	20	on	on	IN
cord-006860-a3b8hyyr	4171	21	131	131	CD
cord-006860-a3b8hyyr	4171	22	samples	sample	NNS
cord-006860-a3b8hyyr	4171	23	from	from	IN
cord-006860-a3b8hyyr	4171	24	normal	normal	JJ
cord-006860-a3b8hyyr	4171	25	individuals	individual	NNS
cord-006860-a3b8hyyr	4171	26	and	and	CC
cord-006860-a3b8hyyr	4171	27	hospitalised	hospitalise	VBN
cord-006860-a3b8hyyr	4171	28	patients	patient	NNS
cord-006860-a3b8hyyr	4171	29	with	with	IN
cord-006860-a3b8hyyr	4171	30	elevated	elevated	JJ
cord-006860-a3b8hyyr	4171	31	D.Dimer	D.Dimer	NNP
cord-006860-a3b8hyyr	4171	32	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4171	33	.	.	.
cord-006860-a3b8hyyr	4172	1	Slope	slope	NN
cord-006860-a3b8hyyr	4172	2	was	be	VBD
cord-006860-a3b8hyyr	4172	3	of	of	IN
cord-006860-a3b8hyyr	4172	4	0.97	0.97	CD
cord-006860-a3b8hyyr	4172	5	and	and	CC
cord-006860-a3b8hyyr	4172	6	intercept	intercept	VB
cord-006860-a3b8hyyr	4172	7	was	be	VBD
cord-006860-a3b8hyyr	4172	8	of	of	IN
cord-006860-a3b8hyyr	4172	9	-0.07	-0.07	CD
cord-006860-a3b8hyyr	4172	10	.	.	.
cord-006860-a3b8hyyr	4173	1	This	this	DT
cord-006860-a3b8hyyr	4173	2	new	new	JJ
cord-006860-a3b8hyyr	4173	3	assay	assay	NN
cord-006860-a3b8hyyr	4173	4	offers	offer	VBZ
cord-006860-a3b8hyyr	4173	5	a	a	DT
cord-006860-a3b8hyyr	4173	6	full	full	JJ
cord-006860-a3b8hyyr	4173	7	flexibility	flexibility	NN
cord-006860-a3b8hyyr	4173	8	for	for	IN
cord-006860-a3b8hyyr	4173	9	individual	individual	JJ
cord-006860-a3b8hyyr	4173	10	testing	testing	NN
cord-006860-a3b8hyyr	4173	11	as	as	IN
cord-006860-a3b8hyyr	4173	12	the	the	DT
cord-006860-a3b8hyyr	4173	13	calibration	calibration	NN
cord-006860-a3b8hyyr	4173	14	curve	curve	NN
cord-006860-a3b8hyyr	4173	15	is	be	VBZ
cord-006860-a3b8hyyr	4173	16	stable	stable	JJ
cord-006860-a3b8hyyr	4173	17	for	for	IN
cord-006860-a3b8hyyr	4173	18	at	at	RB
cord-006860-a3b8hyyr	4173	19	least	least	RBS
cord-006860-a3b8hyyr	4173	20	one	one	CD
cord-006860-a3b8hyyr	4173	21	week	week	NN
cord-006860-a3b8hyyr	4173	22	on	on	IN
cord-006860-a3b8hyyr	4173	23	the	the	DT
cord-006860-a3b8hyyr	4173	24	instrument	instrument	NN
cord-006860-a3b8hyyr	4173	25	.	.	.
cord-006860-a3b8hyyr	4174	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	4174	2	is	be	VBZ
cord-006860-a3b8hyyr	4174	3	then	then	RB
cord-006860-a3b8hyyr	4174	4	well	well	RB
cord-006860-a3b8hyyr	4174	5	adapted	adapt	VBN
cord-006860-a3b8hyyr	4174	6	for	for	IN
cord-006860-a3b8hyyr	4174	7	all	all	PDT
cord-006860-a3b8hyyr	4174	8	the	the	DT
cord-006860-a3b8hyyr	4174	9	applications	application	NNS
cord-006860-a3b8hyyr	4174	10	of	of	IN
cord-006860-a3b8hyyr	4174	11	D.Dimer	d.dimer	JJ
cord-006860-a3b8hyyr	4174	12	measurements	measurement	NNS
cord-006860-a3b8hyyr	4174	13	in	in	IN
cord-006860-a3b8hyyr	4174	14	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4174	15	laboratories	laboratory	NNS
cord-006860-a3b8hyyr	4174	16	.	.	.
cord-006860-a3b8hyyr	4175	1	16	16	CD
cord-006860-a3b8hyyr	4175	2	children	child	NNS
cord-006860-a3b8hyyr	4175	3	between	between	IN
cord-006860-a3b8hyyr	4175	4	an	an	DT
cord-006860-a3b8hyyr	4175	5	age	age	NN
cord-006860-a3b8hyyr	4175	6	of	of	IN
cord-006860-a3b8hyyr	4175	7	3	3	CD
cord-006860-a3b8hyyr	4175	8	days	day	NNS
cord-006860-a3b8hyyr	4175	9	and	and	CC
cord-006860-a3b8hyyr	4175	10	11	11	CD
cord-006860-a3b8hyyr	4175	11	months	month	NNS
cord-006860-a3b8hyyr	4175	12	(	(	-LRB-
cord-006860-a3b8hyyr	4175	13	median	median	NN
cord-006860-a3b8hyyr	4175	14	6	6	CD
cord-006860-a3b8hyyr	4175	15	weeks	week	NNS
cord-006860-a3b8hyyr	4175	16	)	)	-RRB-
cord-006860-a3b8hyyr	4175	17	with	with	IN
cord-006860-a3b8hyyr	4175	18	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	4175	19	or	or	CC
cord-006860-a3b8hyyr	4175	20	embolic	embolic	JJ
cord-006860-a3b8hyyr	4175	21	occlusion	occlusion	NN
cord-006860-a3b8hyyr	4175	22	of	of	IN
cord-006860-a3b8hyyr	4175	23	major	major	JJ
cord-006860-a3b8hyyr	4175	24	vessels	vessel	NNS
cord-006860-a3b8hyyr	4175	25	were	be	VBD
cord-006860-a3b8hyyr	4175	26	treated	treat	VBN
cord-006860-a3b8hyyr	4175	27	with	with	IN
cord-006860-a3b8hyyr	4175	28	rt	rt	NNP
cord-006860-a3b8hyyr	4175	29	-	-	HYPH
cord-006860-a3b8hyyr	4175	30	PA	PA	NNP
cord-006860-a3b8hyyr	4175	31	for	for	IN
cord-006860-a3b8hyyr	4175	32	thrombolysis	thrombolysis	NNP
cord-006860-a3b8hyyr	4175	33	.	.	.
cord-006860-a3b8hyyr	4176	1	The	the	DT
cord-006860-a3b8hyyr	4176	2	affected	affected	JJ
cord-006860-a3b8hyyr	4176	3	vessels	vessel	NNS
cord-006860-a3b8hyyr	4176	4	were	be	VBD
cord-006860-a3b8hyyr	4176	5	both	both	DT
cord-006860-a3b8hyyr	4176	6	sided	sided	JJ
cord-006860-a3b8hyyr	4176	7	renal	renal	JJ
cord-006860-a3b8hyyr	4176	8	veins	vein	NNS
cord-006860-a3b8hyyr	4176	9	or	or	CC
cord-006860-a3b8hyyr	4176	10	one	one	CD
cord-006860-a3b8hyyr	4176	11	sided	sided	JJ
cord-006860-a3b8hyyr	4176	12	renal	renal	JJ
cord-006860-a3b8hyyr	4176	13	vein	vein	NN
cord-006860-a3b8hyyr	4176	14	and	and	CC
cord-006860-a3b8hyyr	4176	15	V.	V.	NNP
cord-006860-a3b8hyyr	4176	16	cava	cava	NNP
cord-006860-a3b8hyyr	4176	17	inf	inf	NNP
cord-006860-a3b8hyyr	4176	18	.	.	.
cord-006860-a3b8hyyr	4177	1	in	in	IN
cord-006860-a3b8hyyr	4177	2	8	8	CD
cord-006860-a3b8hyyr	4177	3	cases	case	NNS
cord-006860-a3b8hyyr	4177	4	,	,	,
cord-006860-a3b8hyyr	4177	5	the	the	DT
cord-006860-a3b8hyyr	4177	6	V.	V.	NNP
cord-006860-a3b8hyyr	4177	7	cava	cava	NNP
cord-006860-a3b8hyyr	4177	8	superior	superior	JJ
cord-006860-a3b8hyyr	4177	9	in	in	IN
cord-006860-a3b8hyyr	4177	10	3	3	CD
cord-006860-a3b8hyyr	4177	11	,	,	,
cord-006860-a3b8hyyr	4177	12	the	the	DT
cord-006860-a3b8hyyr	4177	13	V.	V.	NNP
cord-006860-a3b8hyyr	4177	14	cava	cava	NNP
cord-006860-a3b8hyyr	4177	15	inf	inf	NNP
cord-006860-a3b8hyyr	4177	16	.	.	.
cord-006860-a3b8hyyr	4177	17	plus	plus	CC
cord-006860-a3b8hyyr	4177	18	renal	renal	JJ
cord-006860-a3b8hyyr	4177	19	veins	vein	NNS
cord-006860-a3b8hyyr	4177	20	plus	plus	CC
cord-006860-a3b8hyyr	4177	21	aorta	aorta	NN
cord-006860-a3b8hyyr	4177	22	in	in	IN
cord-006860-a3b8hyyr	4177	23	1	1	CD
cord-006860-a3b8hyyr	4177	24	,	,	,
cord-006860-a3b8hyyr	4177	25	the	the	DT
cord-006860-a3b8hyyr	4177	26	left	left	JJ
cord-006860-a3b8hyyr	4177	27	ventdcle	ventdcle	NN
cord-006860-a3b8hyyr	4177	28	in	in	IN
cord-006860-a3b8hyyr	4177	29	1	1	CD
cord-006860-a3b8hyyr	4177	30	,	,	,
cord-006860-a3b8hyyr	4177	31	the	the	DT
cord-006860-a3b8hyyr	4177	32	aorta	aorta	NN
cord-006860-a3b8hyyr	4177	33	in	in	IN
cord-006860-a3b8hyyr	4177	34	1	1	CD
cord-006860-a3b8hyyr	4178	1	,	,	,
cord-006860-a3b8hyyr	4178	2	the	the	DT
cord-006860-a3b8hyyr	4178	3	A.	A.	NNP
cord-006860-a3b8hyyr	4178	4	femoralis	femoralis	NNP
cord-006860-a3b8hyyr	4178	5	in	in	IN
cord-006860-a3b8hyyr	4178	6	1	1	CD
cord-006860-a3b8hyyr	4178	7	and	and	CC
cord-006860-a3b8hyyr	4178	8	the	the	DT
cord-006860-a3b8hyyr	4178	9	V.	V.	NNP
cord-006860-a3b8hyyr	4178	10	portae	portae	NNP
cord-006860-a3b8hyyr	4178	11	in	in	IN
cord-006860-a3b8hyyr	4178	12	1	1	CD
cord-006860-a3b8hyyr	4178	13	case	case	NN
cord-006860-a3b8hyyr	4178	14	.	.	.
cord-006860-a3b8hyyr	4179	1	10	10	CD
cord-006860-a3b8hyyr	4179	2	out	out	IN
cord-006860-a3b8hyyr	4179	3	of	of	IN
cord-006860-a3b8hyyr	4179	4	16	16	CD
cord-006860-a3b8hyyr	4179	5	occlusions	occlusion	NNS
cord-006860-a3b8hyyr	4179	6	were	be	VBD
cord-006860-a3b8hyyr	4179	7	associated	associate	VBN
cord-006860-a3b8hyyr	4179	8	with	with	IN
cord-006860-a3b8hyyr	4179	9	an	an	DT
cord-006860-a3b8hyyr	4179	10	indwelling	indwell	VBG
cord-006860-a3b8hyyr	4179	11	catheter	catheter	NN
cord-006860-a3b8hyyr	4179	12	.	.	.
cord-006860-a3b8hyyr	4180	1	Underlying	underlie	VBG
cord-006860-a3b8hyyr	4180	2	dieseases	diesease	NNS
cord-006860-a3b8hyyr	4180	3	were	be	VBD
cord-006860-a3b8hyyr	4180	4	sepsis	sepsis	NN
cord-006860-a3b8hyyr	4180	5	(	(	-LRB-
cord-006860-a3b8hyyr	4180	6	4	4	CD
cord-006860-a3b8hyyr	4180	7	)	)	-RRB-
cord-006860-a3b8hyyr	4180	8	,	,	,
cord-006860-a3b8hyyr	4180	9	prematudty	prematudty	NNP
cord-006860-a3b8hyyr	4180	10	(	(	-LRB-
cord-006860-a3b8hyyr	4180	11	3	3	CD
cord-006860-a3b8hyyr	4180	12	)	)	-RRB-
cord-006860-a3b8hyyr	4180	13	,	,	,
cord-006860-a3b8hyyr	4180	14	vitiurn	vitiurn	NNP
cord-006860-a3b8hyyr	4180	15	(	(	-LRB-
cord-006860-a3b8hyyr	4180	16	2	2	CD
cord-006860-a3b8hyyr	4180	17	)	)	-RRB-
cord-006860-a3b8hyyr	4180	18	,	,	,
cord-006860-a3b8hyyr	4180	19	asphyxia	asphyxia	NN
cord-006860-a3b8hyyr	4180	20	(	(	-LRB-
cord-006860-a3b8hyyr	4180	21	1	1	CD
cord-006860-a3b8hyyr	4180	22	)	)	-RRB-
cord-006860-a3b8hyyr	4180	23	,	,	,
cord-006860-a3b8hyyr	4180	24	short	short	JJ
cord-006860-a3b8hyyr	4180	25	bowel	bowel	NN
cord-006860-a3b8hyyr	4180	26	syndrome	syndrome	NN
cord-006860-a3b8hyyr	4180	27	(	(	-LRB-
cord-006860-a3b8hyyr	4180	28	1	1	CD
cord-006860-a3b8hyyr	4180	29	)	)	-RRB-
cord-006860-a3b8hyyr	4180	30	,	,	,
cord-006860-a3b8hyyr	4180	31	HUS	HUS	NNP
cord-006860-a3b8hyyr	4180	32	(	(	-LRB-
cord-006860-a3b8hyyr	4180	33	1	1	CD
cord-006860-a3b8hyyr	4180	34	)	)	-RRB-
cord-006860-a3b8hyyr	4180	35	,	,	,
cord-006860-a3b8hyyr	4180	36	diabetes	diabetes	NN
cord-006860-a3b8hyyr	4180	37	(	(	-LRB-
cord-006860-a3b8hyyr	4180	38	1	1	CD
cord-006860-a3b8hyyr	4180	39	)	)	-RRB-
cord-006860-a3b8hyyr	4180	40	,	,	,
cord-006860-a3b8hyyr	4180	41	CMV	CMV	NNP
cord-006860-a3b8hyyr	4180	42	(	(	-LRB-
cord-006860-a3b8hyyr	4180	43	1	1	CD
cord-006860-a3b8hyyr	4180	44	)	)	-RRB-
cord-006860-a3b8hyyr	4180	45	,	,	,
cord-006860-a3b8hyyr	4180	46	exsiccosis	exsiccosis	NNP
cord-006860-a3b8hyyr	4180	47	(	(	-LRB-
cord-006860-a3b8hyyr	4180	48	1	1	CD
cord-006860-a3b8hyyr	4180	49	)	)	-RRB-
cord-006860-a3b8hyyr	4180	50	and	and	CC
cord-006860-a3b8hyyr	4180	51	M.	M.	NNP
cord-006860-a3b8hyyr	4180	52	Hirschsprung	Hirschsprung	NNP
cord-006860-a3b8hyyr	4180	53	(	(	-LRB-
cord-006860-a3b8hyyr	4180	54	1	1	CD
cord-006860-a3b8hyyr	4180	55	)	)	-RRB-
cord-006860-a3b8hyyr	4180	56	.	.	.
cord-006860-a3b8hyyr	4181	1	Thrombolysis	Thrombolysis	NNP
cord-006860-a3b8hyyr	4181	2	was	be	VBD
cord-006860-a3b8hyyr	4181	3	performed	perform	VBN
cord-006860-a3b8hyyr	4181	4	with	with	IN
cord-006860-a3b8hyyr	4181	5	an	an	DT
cord-006860-a3b8hyyr	4181	6	bolus	bolus	NN
cord-006860-a3b8hyyr	4181	7	of	of	IN
cord-006860-a3b8hyyr	4181	8	rt	rt	NNP
cord-006860-a3b8hyyr	4181	9	-	-	HYPH
cord-006860-a3b8hyyr	4181	10	PA	PA	NNP
cord-006860-a3b8hyyr	4181	11	(	(	-LRB-
cord-006860-a3b8hyyr	4181	12	0.1	0.1	CD
cord-006860-a3b8hyyr	4181	13	-	-	SYM
cord-006860-a3b8hyyr	4181	14	0.2	0.2	CD
cord-006860-a3b8hyyr	4181	15	mg	mg	NNP
cord-006860-a3b8hyyr	4181	16	/	/	SYM
cord-006860-a3b8hyyr	4181	17	kg	kg	NNP
cord-006860-a3b8hyyr	4181	18	)	)	-RRB-
cord-006860-a3b8hyyr	4181	19	followed	follow	VBN
cord-006860-a3b8hyyr	4181	20	by	by	IN
cord-006860-a3b8hyyr	4181	21	continuous	continuous	JJ
cord-006860-a3b8hyyr	4181	22	infusion	infusion	NN
cord-006860-a3b8hyyr	4181	23	(	(	-LRB-
cord-006860-a3b8hyyr	4181	24	0.8	0.8	CD
cord-006860-a3b8hyyr	4181	25	-	-	SYM
cord-006860-a3b8hyyr	4181	26	2.4	2.4	CD
cord-006860-a3b8hyyr	4181	27	(	(	-LRB-
cord-006860-a3b8hyyr	4181	28	-9	-9	NNP
cord-006860-a3b8hyyr	4181	29	)	)	-RRB-
cord-006860-a3b8hyyr	4181	30	mg	mg	NNP
cord-006860-a3b8hyyr	4181	31	/	/	SYM
cord-006860-a3b8hyyr	4181	32	kg/24h	kg/24h	NNP
cord-006860-a3b8hyyr	4181	33	,	,	,
cord-006860-a3b8hyyr	4181	34	median	median	JJ
cord-006860-a3b8hyyr	4181	35	1.8	1.8	CD
cord-006860-a3b8hyyr	4181	36	mg	mg	NNP
cord-006860-a3b8hyyr	4181	37	/	/	SYM
cord-006860-a3b8hyyr	4181	38	kg/24h	kg/24h	NNP
cord-006860-a3b8hyyr	4181	39	)	)	-RRB-
cord-006860-a3b8hyyr	4181	40	.	.	.
cord-006860-a3b8hyyr	4182	1	Low	low	JJ
cord-006860-a3b8hyyr	4182	2	dose	dose	NN
cord-006860-a3b8hyyr	4182	3	hepadn	hepadn	NNP
cord-006860-a3b8hyyr	4182	4	(	(	-LRB-
cord-006860-a3b8hyyr	4182	5	100	100	CD
cord-006860-a3b8hyyr	4182	6	IE	IE	NNP
cord-006860-a3b8hyyr	4182	7	/	/	SYM
cord-006860-a3b8hyyr	4182	8	kg/24h	kg/24h	NNP
cord-006860-a3b8hyyr	4182	9	)	)	-RRB-
cord-006860-a3b8hyyr	4182	10	was	be	VBD
cord-006860-a3b8hyyr	4182	11	given	give	VBN
cord-006860-a3b8hyyr	4182	12	dudng	dudng	NNP
cord-006860-a3b8hyyr	4182	13	full	full	JJ
cord-006860-a3b8hyyr	4182	14	dose	dose	NN
cord-006860-a3b8hyyr	4182	15	hepadn	hepadn	NNP
cord-006860-a3b8hyyr	4182	16	(	(	-LRB-
cord-006860-a3b8hyyr	4182	17	aPTT	aPTT	NNS
cord-006860-a3b8hyyr	4182	18	1,5	1,5	CD
cord-006860-a3b8hyyr	4182	19	-	-	HYPH
cord-006860-a3b8hyyr	4182	20	2	2	CD
cord-006860-a3b8hyyr	4182	21	times	time	NNS
cord-006860-a3b8hyyr	4182	22	normal	normal	JJ
cord-006860-a3b8hyyr	4182	23	)	)	-RRB-
cord-006860-a3b8hyyr	4182	24	after	after	IN
cord-006860-a3b8hyyr	4182	25	the	the	DT
cord-006860-a3b8hyyr	4182	26	thrombolysis	thrombolysis	NN
cord-006860-a3b8hyyr	4182	27	.	.	.
cord-006860-a3b8hyyr	4183	1	In	in	IN
cord-006860-a3b8hyyr	4183	2	5	5	CD
cord-006860-a3b8hyyr	4183	3	pts	pt	NNS
cord-006860-a3b8hyyr	4183	4	.	.	.
cord-006860-a3b8hyyr	4184	1	rt	rt	NNP
cord-006860-a3b8hyyr	4184	2	-	-	HYPH
cord-006860-a3b8hyyr	4184	3	PA	PA	NNP
cord-006860-a3b8hyyr	4184	4	was	be	VBD
cord-006860-a3b8hyyr	4184	5	administered	administer	VBN
cord-006860-a3b8hyyr	4184	6	locally	locally	RB
cord-006860-a3b8hyyr	4184	7	through	through	IN
cord-006860-a3b8hyyr	4184	8	the	the	DT
cord-006860-a3b8hyyr	4184	9	catheter	catheter	NN
cord-006860-a3b8hyyr	4184	10	and	and	CC
cord-006860-a3b8hyyr	4184	11	in	in	IN
cord-006860-a3b8hyyr	4184	12	11	11	CD
cord-006860-a3b8hyyr	4184	13	cases	case	NNS
cord-006860-a3b8hyyr	4184	14	systemically	systemically	RB
cord-006860-a3b8hyyr	4184	15	.	.	.
cord-006860-a3b8hyyr	4185	1	In	in	IN
cord-006860-a3b8hyyr	4185	2	13	13	CD
cord-006860-a3b8hyyr	4185	3	patients	patient	NNS
cord-006860-a3b8hyyr	4185	4	the	the	DT
cord-006860-a3b8hyyr	4185	5	vessels	vessel	NNS
cord-006860-a3b8hyyr	4185	6	could	could	MD
cord-006860-a3b8hyyr	4185	7	be	be	VB
cord-006860-a3b8hyyr	4185	8	recanalised	recanalise	VBN
cord-006860-a3b8hyyr	4185	9	completely	completely	RB
cord-006860-a3b8hyyr	4185	10	,	,	,
cord-006860-a3b8hyyr	4185	11	in	in	IN
cord-006860-a3b8hyyr	4185	12	2	2	CD
cord-006860-a3b8hyyr	4185	13	partially	partially	RB
cord-006860-a3b8hyyr	4185	14	,	,	,
cord-006860-a3b8hyyr	4185	15	in	in	IN
cord-006860-a3b8hyyr	4185	16	1	1	CD
cord-006860-a3b8hyyr	4185	17	patient	patient	NN
cord-006860-a3b8hyyr	4185	18	the	the	DT
cord-006860-a3b8hyyr	4185	19	therapy	therapy	NN
cord-006860-a3b8hyyr	4185	20	had	have	VBD
cord-006860-a3b8hyyr	4185	21	to	to	TO
cord-006860-a3b8hyyr	4185	22	be	be	VB
cord-006860-a3b8hyyr	4185	23	discontinued	discontinue	VBN
cord-006860-a3b8hyyr	4185	24	.	.	.
cord-006860-a3b8hyyr	4186	1	In	in	IN
cord-006860-a3b8hyyr	4186	2	2	2	CD
cord-006860-a3b8hyyr	4186	3	vessels	vessel	NNS
cord-006860-a3b8hyyr	4186	4	a	a	DT
cord-006860-a3b8hyyr	4186	5	reocclusion	reocclusion	NN
cord-006860-a3b8hyyr	4186	6	occurred	occur	VBD
cord-006860-a3b8hyyr	4186	7	.	.	.
cord-006860-a3b8hyyr	4187	1	Bleedings	bleeding	NNS
cord-006860-a3b8hyyr	4187	2	were	be	VBD
cord-006860-a3b8hyyr	4187	3	noted	note	VBN
cord-006860-a3b8hyyr	4187	4	in	in	IN
cord-006860-a3b8hyyr	4187	5	three	three	CD
cord-006860-a3b8hyyr	4187	6	patients	patient	NNS
cord-006860-a3b8hyyr	4187	7	,	,	,
cord-006860-a3b8hyyr	4187	8	all	all	RB
cord-006860-a3b8hyyr	4187	9	from	from	IN
cord-006860-a3b8hyyr	4187	10	recent	recent	JJ
cord-006860-a3b8hyyr	4187	11	venous	venous	JJ
cord-006860-a3b8hyyr	4187	12	puncture	puncture	NN
cord-006860-a3b8hyyr	4187	13	sites	site	NNS
cord-006860-a3b8hyyr	4187	14	.	.	.
cord-006860-a3b8hyyr	4188	1	The	the	DT
cord-006860-a3b8hyyr	4188	2	results	result	NNS
cord-006860-a3b8hyyr	4188	3	encouraged	encourage	VBD
cord-006860-a3b8hyyr	4188	4	us	-PRON-	PRP
cord-006860-a3b8hyyr	4188	5	to	to	TO
cord-006860-a3b8hyyr	4188	6	start	start	VB
cord-006860-a3b8hyyr	4188	7	a	a	DT
cord-006860-a3b8hyyr	4188	8	multi	multi	JJ
cord-006860-a3b8hyyr	4188	9	-	-	JJ
cord-006860-a3b8hyyr	4188	10	canter	canter	JJ
cord-006860-a3b8hyyr	4188	11	trial	trial	NN
cord-006860-a3b8hyyr	4188	12	which	which	WDT
cord-006860-a3b8hyyr	4188	13	has	have	VBZ
cord-006860-a3b8hyyr	4188	14	been	be	VBN
cord-006860-a3b8hyyr	4188	15	approved	approve	VBN
cord-006860-a3b8hyyr	4188	16	by	by	IN
cord-006860-a3b8hyyr	4188	17	the	the	DT
cord-006860-a3b8hyyr	4188	18	ethical	ethical	JJ
cord-006860-a3b8hyyr	4188	19	committee	committee	NN
cord-006860-a3b8hyyr	4188	20	and	and	CC
cord-006860-a3b8hyyr	4188	21	is	be	VBZ
cord-006860-a3b8hyyr	4188	22	open	open	JJ
cord-006860-a3b8hyyr	4188	23	for	for	IN
cord-006860-a3b8hyyr	4188	24	recrural	recrural	JJ
cord-006860-a3b8hyyr	4188	25	.	.	.
cord-006860-a3b8hyyr	4189	1	The	the	DT
cord-006860-a3b8hyyr	4189	2	aim	aim	NN
cord-006860-a3b8hyyr	4189	3	is	be	VBZ
cord-006860-a3b8hyyr	4189	4	to	to	TO
cord-006860-a3b8hyyr	4189	5	compare	compare	VB
cord-006860-a3b8hyyr	4189	6	efficacy	efficacy	NN
cord-006860-a3b8hyyr	4189	7	and	and	CC
cord-006860-a3b8hyyr	4189	8	safety	safety	NN
cord-006860-a3b8hyyr	4189	9	of	of	IN
cord-006860-a3b8hyyr	4189	10	rt	rt	NNP
cord-006860-a3b8hyyr	4189	11	-	-	HYPH
cord-006860-a3b8hyyr	4189	12	PA	PA	NNP
cord-006860-a3b8hyyr	4189	13	with	with	IN
cord-006860-a3b8hyyr	4189	14	urokinase	urokinase	NN
cord-006860-a3b8hyyr	4189	15	,	,	,
cord-006860-a3b8hyyr	4189	16	the	the	DT
cord-006860-a3b8hyyr	4189	17	only	only	RB
cord-006860-a3b8hyyr	4189	18	recommended	recommend	VBN
cord-006860-a3b8hyyr	4189	19	standard	standard	NN
cord-006860-a3b8hyyr	4189	20	in	in	IN
cord-006860-a3b8hyyr	4189	21	the	the	DT
cord-006860-a3b8hyyr	4189	22	management	management	NN
cord-006860-a3b8hyyr	4189	23	of	of	IN
cord-006860-a3b8hyyr	4189	24	critical	critical	JJ
cord-006860-a3b8hyyr	4189	25	major	major	JJ
cord-006860-a3b8hyyr	4189	26	vessel	vessel	NN
cord-006860-a3b8hyyr	4189	27	obstruction	obstruction	NN
cord-006860-a3b8hyyr	4189	28	in	in	IN
cord-006860-a3b8hyyr	4189	29	newborns	newborn	NNS
cord-006860-a3b8hyyr	4189	30	and	and	CC
cord-006860-a3b8hyyr	4189	31	infants	infant	NNS
cord-006860-a3b8hyyr	4189	32	.	.	.
cord-006860-a3b8hyyr	4190	1	The	the	DT
cord-006860-a3b8hyyr	4190	2	design	design	NN
cord-006860-a3b8hyyr	4190	3	is	be	VBZ
cord-006860-a3b8hyyr	4190	4	a	a	DT
cord-006860-a3b8hyyr	4190	5	randomised	randomised	JJ
cord-006860-a3b8hyyr	4190	6	,	,	,
cord-006860-a3b8hyyr	4190	7	notblinded	notblinded	JJ
cord-006860-a3b8hyyr	4190	8	trial	trial	NN
cord-006860-a3b8hyyr	4190	9	with	with	IN
cord-006860-a3b8hyyr	4190	10	a	a	DT
cord-006860-a3b8hyyr	4190	11	cross	cross	JJ
cord-006860-a3b8hyyr	4190	12	-	-	HYPH
cord-006860-a3b8hyyr	4190	13	over	over	RP
cord-006860-a3b8hyyr	4190	14	option	option	NN
cord-006860-a3b8hyyr	4190	15	after	after	IN
cord-006860-a3b8hyyr	4190	16	three	three	CD
cord-006860-a3b8hyyr	4190	17	days	day	NNS
cord-006860-a3b8hyyr	4190	18	in	in	IN
cord-006860-a3b8hyyr	4190	19	cases	case	NNS
cord-006860-a3b8hyyr	4190	20	without	without	IN
cord-006860-a3b8hyyr	4190	21	success	success	NN
cord-006860-a3b8hyyr	4190	22	.	.	.
cord-006860-a3b8hyyr	4191	1	Study	study	NN
cord-006860-a3b8hyyr	4191	2	end	end	NN
cord-006860-a3b8hyyr	4191	3	points	point	NNS
cord-006860-a3b8hyyr	4191	4	are	be	VBP
cord-006860-a3b8hyyr	4191	5	recanalisations	recanalisation	NNS
cord-006860-a3b8hyyr	4191	6	,	,	,
cord-006860-a3b8hyyr	4191	7	major	major	JJ
cord-006860-a3b8hyyr	4191	8	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	4191	9	and	and	CC
cord-006860-a3b8hyyr	4191	10	number	number	NN
cord-006860-a3b8hyyr	4191	11	of	of	IN
cord-006860-a3b8hyyr	4191	12	cross	cross	NN
cord-006860-a3b8hyyr	4191	13	-	-	NNS
cord-006860-a3b8hyyr	4191	14	overs	over	NNS
cord-006860-a3b8hyyr	4191	15	.	.	.
cord-006860-a3b8hyyr	4192	1	Inclusion	inclusion	NN
cord-006860-a3b8hyyr	4192	2	criteria	criterion	NNS
cord-006860-a3b8hyyr	4192	3	are	be	VBP
cord-006860-a3b8hyyr	4192	4	age	age	NN
cord-006860-a3b8hyyr	4192	5	under	under	IN
cord-006860-a3b8hyyr	4192	6	1	1	CD
cord-006860-a3b8hyyr	4192	7	year	year	NN
cord-006860-a3b8hyyr	4192	8	,	,	,
cord-006860-a3b8hyyr	4192	9	lifethreatening	lifethreatening	JJ
cord-006860-a3b8hyyr	4192	10	vessel	vessel	NN
cord-006860-a3b8hyyr	4192	11	obstruction	obstruction	NN
cord-006860-a3b8hyyr	4192	12	,	,	,
cord-006860-a3b8hyyr	4192	13	age	age	NN
cord-006860-a3b8hyyr	4192	14	of	of	IN
cord-006860-a3b8hyyr	4192	15	thrombus	thrombus	NN
cord-006860-a3b8hyyr	4192	16	up	up	IN
cord-006860-a3b8hyyr	4192	17	to	to	TO
cord-006860-a3b8hyyr	4192	18	10	10	CD
cord-006860-a3b8hyyr	4192	19	days	day	NNS
cord-006860-a3b8hyyr	4192	20	,	,	,
cord-006860-a3b8hyyr	4192	21	no	no	DT
cord-006860-a3b8hyyr	4192	22	precaeding	precaede	VBG
cord-006860-a3b8hyyr	4192	23	fibdnolytic	fibdnolytic	JJ
cord-006860-a3b8hyyr	4192	24	therapy	therapy	NN
cord-006860-a3b8hyyr	4192	25	.	.	.
cord-006860-a3b8hyyr	4193	1	Exclusion	exclusion	NN
cord-006860-a3b8hyyr	4193	2	cdteda	cdteda	NN
cord-006860-a3b8hyyr	4193	3	are	be	VBP
cord-006860-a3b8hyyr	4193	4	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	4193	5	hemorrage	hemorrage	NNP
cord-006860-a3b8hyyr	4193	6	,	,	,
cord-006860-a3b8hyyr	4193	7	pedventricular	pedventricular	NNP
cord-006860-a3b8hyyr	4193	8	leukomalacia	leukomalacia	NNP
cord-006860-a3b8hyyr	4193	9	,	,	,
cord-006860-a3b8hyyr	4193	10	surgery	surgery	NN
cord-006860-a3b8hyyr	4193	11	dudng	dudng	NNP
cord-006860-a3b8hyyr	4194	1	the	the	DT
cord-006860-a3b8hyyr	4194	2	last	last	JJ
cord-006860-a3b8hyyr	4194	3	7	7	CD
cord-006860-a3b8hyyr	4194	4	days	day	NNS
cord-006860-a3b8hyyr	4194	5	and	and	CC
cord-006860-a3b8hyyr	4194	6	CNS	CNS	NNP
cord-006860-a3b8hyyr	4194	7	injuries	injury	NNS
cord-006860-a3b8hyyr	4194	8	during	during	IN
cord-006860-a3b8hyyr	4194	9	the	the	DT
cord-006860-a3b8hyyr	4194	10	last	last	JJ
cord-006860-a3b8hyyr	4194	11	2	2	CD
cord-006860-a3b8hyyr	4194	12	months	month	NNS
cord-006860-a3b8hyyr	4194	13	.	.	.
cord-006860-a3b8hyyr	4195	1	Although	although	IN
cord-006860-a3b8hyyr	4195	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4195	3	knowledge	knowledge	NN
cord-006860-a3b8hyyr	4195	4	on	on	IN
cord-006860-a3b8hyyr	4195	5	inherited	inherit	VBN
cord-006860-a3b8hyyr	4195	6	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	4195	7	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4195	8	disorders	disorder	NNS
cord-006860-a3b8hyyr	4195	9	has	have	VBZ
cord-006860-a3b8hyyr	4195	10	greatly	greatly	RB
cord-006860-a3b8hyyr	4195	11	expanded	expand	VBN
cord-006860-a3b8hyyr	4195	12	within	within	IN
cord-006860-a3b8hyyr	4195	13	the	the	DT
cord-006860-a3b8hyyr	4195	14	last	last	JJ
cord-006860-a3b8hyyr	4195	15	years	year	NNS
cord-006860-a3b8hyyr	4195	16	,	,	,
cord-006860-a3b8hyyr	4195	17	there	there	EX
cord-006860-a3b8hyyr	4195	18	are	be	VBP
cord-006860-a3b8hyyr	4195	19	still	still	RB
cord-006860-a3b8hyyr	4195	20	man	man	NN
cord-006860-a3b8hyyr	4195	21	}	}	-RRB-
cord-006860-a3b8hyyr	4195	22	,	,	,
cord-006860-a3b8hyyr	4195	23	patients	patient	NNS
cord-006860-a3b8hyyr	4195	24	with	with	IN
cord-006860-a3b8hyyr	4195	25	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	4195	26	venous	venous	JJ
cord-006860-a3b8hyyr	4195	27	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4195	28	in	in	IN
cord-006860-a3b8hyyr	4195	29	whom	whom	WP
cord-006860-a3b8hyyr	4195	30	no	no	DT
cord-006860-a3b8hyyr	4195	31	obvious	obvious	JJ
cord-006860-a3b8hyyr	4195	32	predasposition	predasposition	NN
cord-006860-a3b8hyyr	4195	33	can	can	MD
cord-006860-a3b8hyyr	4195	34	be	be	VB
cord-006860-a3b8hyyr	4195	35	identified	identify	VBN
cord-006860-a3b8hyyr	4195	36	.	.	.
cord-006860-a3b8hyyr	4196	1	Thus	thus	RB
cord-006860-a3b8hyyr	4196	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	4196	3	decided	decide	VBD
cord-006860-a3b8hyyr	4196	4	to	to	TO
cord-006860-a3b8hyyr	4196	5	include	include	VB
cord-006860-a3b8hyyr	4196	6	also	also	RB
cord-006860-a3b8hyyr	4196	7	so	so	RB
cord-006860-a3b8hyyr	4196	8	-	-	HYPH
cord-006860-a3b8hyyr	4196	9	called	call	VBN
cord-006860-a3b8hyyr	4196	10	rare	rare	JJ
cord-006860-a3b8hyyr	4196	11	defects	defect	NNS
cord-006860-a3b8hyyr	4196	12	associated	associate	VBN
cord-006860-a3b8hyyr	4196	13	with	with	IN
cord-006860-a3b8hyyr	4196	14	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4196	15	in	in	IN
cord-006860-a3b8hyyr	4196	16	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4196	17	routine	routine	JJ
cord-006860-a3b8hyyr	4196	18	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	4196	19	screening	screening	NN
cord-006860-a3b8hyyr	4196	20	programme	programme	NN
cord-006860-a3b8hyyr	4196	21	,	,	,
cord-006860-a3b8hyyr	4196	22	such	such	JJ
cord-006860-a3b8hyyr	4196	23	as	as	IN
cord-006860-a3b8hyyr	4196	24	FXII	FXII	NNP
cord-006860-a3b8hyyr	4196	25	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4196	26	.	.	.
cord-006860-a3b8hyyr	4197	1	FXII	FXII	NNP
cord-006860-a3b8hyyr	4197	2	is	be	VBZ
cord-006860-a3b8hyyr	4197	3	an	an	DT
cord-006860-a3b8hyyr	4197	4	important	important	JJ
cord-006860-a3b8hyyr	4197	5	element	element	NN
cord-006860-a3b8hyyr	4197	6	m	m	NN
cord-006860-a3b8hyyr	4197	7	the	the	DT
cord-006860-a3b8hyyr	4197	8	intrinsic	intrinsic	JJ
cord-006860-a3b8hyyr	4197	9	pathway	pathway	NN
cord-006860-a3b8hyyr	4197	10	of	of	IN
cord-006860-a3b8hyyr	4197	11	fibrinolysis	fibrinolysis	NNP
cord-006860-a3b8hyyr	4198	1	and	and	CC
cord-006860-a3b8hyyr	4198	2	there	there	EX
cord-006860-a3b8hyyr	4198	3	is	be	VBZ
cord-006860-a3b8hyyr	4198	4	evidence	evidence	NN
cord-006860-a3b8hyyr	4198	5	for	for	IN
cord-006860-a3b8hyyr	4198	6	an	an	DT
cord-006860-a3b8hyyr	4198	7	insufficient	insufficient	JJ
cord-006860-a3b8hyyr	4198	8	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4198	9	activity	activity	NN
cord-006860-a3b8hyyr	4198	10	in	in	IN
cord-006860-a3b8hyyr	4198	11	FXII	FXII	NNP
cord-006860-a3b8hyyr	4198	12	deficient	deficient	JJ
cord-006860-a3b8hyyr	4198	13	pts	pt	NNS
cord-006860-a3b8hyyr	4198	14	..	..	.
cord-006860-a3b8hyyr	4199	1	Up	up	IN
cord-006860-a3b8hyyr	4199	2	to	to	IN
cord-006860-a3b8hyyr	4199	3	date	date	NN
cord-006860-a3b8hyyr	4199	4	only	only	RB
cord-006860-a3b8hyyr	4199	5	few	few	JJ
cord-006860-a3b8hyyr	4199	6	and	and	CC
cord-006860-a3b8hyyr	4199	7	controversial	controversial	JJ
cord-006860-a3b8hyyr	4199	8	data	datum	NNS
cord-006860-a3b8hyyr	4199	9	exist	exist	VBP
cord-006860-a3b8hyyr	4199	10	about	about	IN
cord-006860-a3b8hyyr	4199	11	the	the	DT
cord-006860-a3b8hyyr	4199	12	frequency	frequency	NN
cord-006860-a3b8hyyr	4199	13	of	of	IN
cord-006860-a3b8hyyr	4199	14	FXII	FXII	NNP
cord-006860-a3b8hyyr	4199	15	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4199	16	in	in	IN
cord-006860-a3b8hyyr	4199	17	pts	pts	NN
cord-006860-a3b8hyyr	4199	18	.	.	.
cord-006860-a3b8hyyr	4200	1	with	with	IN
cord-006860-a3b8hyyr	4200	2	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	4200	3	.	.	.
cord-006860-a3b8hyyr	4201	1	Cons	con	NNS
cord-006860-a3b8hyyr	4201	2	~	~	NFP
cord-006860-a3b8hyyr	4201	3	uently	uently	NN
cord-006860-a3b8hyyr	4201	4	the	the	DT
cord-006860-a3b8hyyr	4201	5	aim	aim	NN
cord-006860-a3b8hyyr	4201	6	of	of	IN
cord-006860-a3b8hyyr	4201	7	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4201	8	study	study	NN
cord-006860-a3b8hyyr	4201	9	was	be	VBD
cord-006860-a3b8hyyr	4201	10	to	to	TO
cord-006860-a3b8hyyr	4201	11	evaluate	evaluate	VB
cord-006860-a3b8hyyr	4201	12	the	the	DT
cord-006860-a3b8hyyr	4201	13	association	association	NN
cord-006860-a3b8hyyr	4201	14	between	between	IN
cord-006860-a3b8hyyr	4201	15	FXII	FXII	NNP
cord-006860-a3b8hyyr	4201	16	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4201	17	and	and	CC
cord-006860-a3b8hyyr	4201	18	juvenile	juvenile	JJ
cord-006860-a3b8hyyr	4201	19	venous	venous	JJ
cord-006860-a3b8hyyr	4201	20	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4201	21	in	in	IN
cord-006860-a3b8hyyr	4201	22	a	a	DT
cord-006860-a3b8hyyr	4201	23	great	great	JJ
cord-006860-a3b8hyyr	4201	24	population	population	NN
cord-006860-a3b8hyyr	4201	25	.	.	.
cord-006860-a3b8hyyr	4202	1	Patients	patient	NNS
cord-006860-a3b8hyyr	4202	2	and	and	CC
cord-006860-a3b8hyyr	4202	3	methods	method	NNS
cord-006860-a3b8hyyr	4202	4	:	:	:
cord-006860-a3b8hyyr	4202	5	1554	1554	CD
cord-006860-a3b8hyyr	4202	6	pts	pt	NNS
cord-006860-a3b8hyyr	4202	7	.	.	.
cord-006860-a3b8hyyr	4203	1	(	(	-LRB-
cord-006860-a3b8hyyr	4203	2	851	851	CD
cord-006860-a3b8hyyr	4203	3	female	female	JJ
cord-006860-a3b8hyyr	4203	4	,	,	,
cord-006860-a3b8hyyr	4203	5	703	703	CD
cord-006860-a3b8hyyr	4203	6	male	male	NN
cord-006860-a3b8hyyr	4203	7	,	,	,
cord-006860-a3b8hyyr	4203	8	aged	age	VBN
cord-006860-a3b8hyyr	4203	9	I	-PRON-	PRP
cord-006860-a3b8hyyr	4203	10	to	to	IN
cord-006860-a3b8hyyr	4203	11	61	61	CD
cord-006860-a3b8hyyr	4203	12	ys	ys	NN
cord-006860-a3b8hyyr	4203	13	,	,	,
cord-006860-a3b8hyyr	4203	14	median	median	JJ
cord-006860-a3b8hyyr	4203	15	age	age	NN
cord-006860-a3b8hyyr	4203	16	38.2	38.2	CD
cord-006860-a3b8hyyr	4203	17	ys	ys	NNP
cord-006860-a3b8hyyr	4203	18	)	)	-RRB-
cord-006860-a3b8hyyr	4203	19	with	with	IN
cord-006860-a3b8hyyr	4203	20	venous	venous	JJ
cord-006860-a3b8hyyr	4203	21	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	4203	22	before	before	IN
cord-006860-a3b8hyyr	4203	23	the	the	DT
cord-006860-a3b8hyyr	4203	24	age	age	NN
cord-006860-a3b8hyyr	4203	25	of	of	IN
cord-006860-a3b8hyyr	4203	26	45	45	CD
cord-006860-a3b8hyyr	4203	27	ys	y	NNS
cord-006860-a3b8hyyr	4203	28	were	be	VBD
cord-006860-a3b8hyyr	4203	29	studied	study	VBN
cord-006860-a3b8hyyr	4203	30	.	.	.
cord-006860-a3b8hyyr	4204	1	One	one	CD
cord-006860-a3b8hyyr	4204	2	-	-	HYPH
cord-006860-a3b8hyyr	4204	3	stage	stage	NN
cord-006860-a3b8hyyr	4204	4	clotting	clotting	NN
cord-006860-a3b8hyyr	4204	5	activity	activity	NN
cord-006860-a3b8hyyr	4204	6	assay	assay	NN
cord-006860-a3b8hyyr	4204	7	of	of	IN
cord-006860-a3b8hyyr	4204	8	FXII	FXII	NNP
cord-006860-a3b8hyyr	4204	9	(	(	-LRB-
cord-006860-a3b8hyyr	4204	10	FXII	FXII	NNP
cord-006860-a3b8hyyr	4204	11	:	:	:
cord-006860-a3b8hyyr	4204	12	C	C	NNP
cord-006860-a3b8hyyr	4204	13	)	)	-RRB-
cord-006860-a3b8hyyr	4204	14	was	be	VBD
cord-006860-a3b8hyyr	4204	15	performed	perform	VBN
cord-006860-a3b8hyyr	4204	16	on	on	IN
cord-006860-a3b8hyyr	4204	17	ACL	ACL	NNP
cord-006860-a3b8hyyr	4204	18	using	use	VBG
cord-006860-a3b8hyyr	4204	19	FXII	FXII	NNP
cord-006860-a3b8hyyr	4204	20	deficient	deficient	JJ
cord-006860-a3b8hyyr	4204	21	plasma	plasma	NN
cord-006860-a3b8hyyr	4204	22	from	from	IN
cord-006860-a3b8hyyr	4204	23	Instrumentation	Instrumentation	NNP
cord-006860-a3b8hyyr	4204	24	Laborato~.	laborato~.	CD
cord-006860-a3b8hyyr	4204	25	FXII	FXII	NNP
cord-006860-a3b8hyyr	4204	26	antigen	antigen	NN
cord-006860-a3b8hyyr	4204	27	concentration	concentration	NN
cord-006860-a3b8hyyr	4204	28	(	(	-LRB-
cord-006860-a3b8hyyr	4204	29	FXII	FXII	NNP
cord-006860-a3b8hyyr	4204	30	:	:	:
cord-006860-a3b8hyyr	4204	31	Ag	Ag	NNP
cord-006860-a3b8hyyr	4204	32	)	)	-RRB-
cord-006860-a3b8hyyr	4205	1	was	be	VBD
cord-006860-a3b8hyyr	4205	2	measured	measure	VBN
cord-006860-a3b8hyyr	4205	3	by	by	IN
cord-006860-a3b8hyyr	4205	4	electroimmundiffusion	electroimmundiffusion	NN
cord-006860-a3b8hyyr	4205	5	using	use	VBG
cord-006860-a3b8hyyr	4205	6	reagents	reagent	NNS
cord-006860-a3b8hyyr	4205	7	from	from	IN
cord-006860-a3b8hyyr	4205	8	Behfingwerke	Behfingwerke	NNP
cord-006860-a3b8hyyr	4205	9	,	,	,
cord-006860-a3b8hyyr	4205	10	Enzym	Enzym	NNP
cord-006860-a3b8hyyr	4205	11	research	research	NN
cord-006860-a3b8hyyr	4205	12	respectively	respectively	RB
cord-006860-a3b8hyyr	4205	13	.	.	.
cord-006860-a3b8hyyr	4206	1	The	the	DT
cord-006860-a3b8hyyr	4206	2	normal	normal	JJ
cord-006860-a3b8hyyr	4206	3	ranges	range	NNS
cord-006860-a3b8hyyr	4206	4	are	be	VBP
cord-006860-a3b8hyyr	4206	5	tl~.	tl~.	VBN
cord-006860-a3b8hyyr	4206	6	routine	routine	JJ
cord-006860-a3b8hyyr	4206	7	reference	reference	NN
cord-006860-a3b8hyyr	4206	8	values	value	NNS
cord-006860-a3b8hyyr	4206	9	obtained	obtain	VBD
cord-006860-a3b8hyyr	4206	10	m	m	NNP
cord-006860-a3b8hyyr	4206	11	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4206	12	labratory	labratory	NN
cord-006860-a3b8hyyr	4206	13	from	from	IN
cord-006860-a3b8hyyr	4206	14	80	80	CD
cord-006860-a3b8hyyr	4206	15	healthy	healthy	JJ
cord-006860-a3b8hyyr	4206	16	subjects	subject	NNS
cord-006860-a3b8hyyr	4206	17	(	(	-LRB-
cord-006860-a3b8hyyr	4206	18	40	40	CD
cord-006860-a3b8hyyr	4206	19	males	male	NNS
cord-006860-a3b8hyyr	4206	20	,	,	,
cord-006860-a3b8hyyr	4206	21	40	40	CD
cord-006860-a3b8hyyr	4206	22	females	female	NNS
cord-006860-a3b8hyyr	4206	23	,	,	,
cord-006860-a3b8hyyr	4206	24	median	median	JJ
cord-006860-a3b8hyyr	4206	25	age	age	NN
cord-006860-a3b8hyyr	4206	26	26.2	26.2	CD
cord-006860-a3b8hyyr	4206	27	ys	ys	NN
cord-006860-a3b8hyyr	4206	28	)	)	-RRB-
cord-006860-a3b8hyyr	4206	29	;	;	:
cord-006860-a3b8hyyr	4206	30	95	95	CD
cord-006860-a3b8hyyr	4206	31	%	%	NN
cord-006860-a3b8hyyr	4206	32	range	range	NN
cord-006860-a3b8hyyr	4206	33	:	:	:
cord-006860-a3b8hyyr	4206	34	FXII	FXII	NNP
cord-006860-a3b8hyyr	4206	35	:	:	:
cord-006860-a3b8hyyr	4207	1	C	C	NNP
cord-006860-a3b8hyyr	4207	2	53	53	CD
cord-006860-a3b8hyyr	4207	3	-	-	SYM
cord-006860-a3b8hyyr	4207	4	135	135	CD
cord-006860-a3b8hyyr	4207	5	%	%	NN
cord-006860-a3b8hyyr	4207	6	,	,	,
cord-006860-a3b8hyyr	4207	7	FXII	FXII	NNP
cord-006860-a3b8hyyr	4207	8	:	:	:
cord-006860-a3b8hyyr	4208	1	Ag	Ag	NNP
cord-006860-a3b8hyyr	4208	2	57	57	CD
cord-006860-a3b8hyyr	4208	3	-	-	SYM
cord-006860-a3b8hyyr	4208	4	132	132	CD
cord-006860-a3b8hyyr	4208	5	%	%	NN
cord-006860-a3b8hyyr	4208	6	)	)	-RRB-
cord-006860-a3b8hyyr	4208	7	.	.	.
cord-006860-a3b8hyyr	4209	1	Results	result	NNS
cord-006860-a3b8hyyr	4209	2	:	:	:
cord-006860-a3b8hyyr	4210	1	122/1554	122/1554	LS
cord-006860-a3b8hyyr	4211	1	pts.were	pts.were	RB
cord-006860-a3b8hyyr	4211	2	classified	classify	VBN
cord-006860-a3b8hyyr	4211	3	as	as	IN
cord-006860-a3b8hyyr	4211	4	FXI1	FXI1	NNP
cord-006860-a3b8hyyr	4211	5	deficient	deficient	JJ
cord-006860-a3b8hyyr	4212	1	(	(	-LRB-
cord-006860-a3b8hyyr	4212	2	F	F	NNP
cord-006860-a3b8hyyr	4212	3	60	60	CD
cord-006860-a3b8hyyr	4212	4	,	,	,
cord-006860-a3b8hyyr	4212	5	M	M	NNP
cord-006860-a3b8hyyr	4212	6	62	62	CD
cord-006860-a3b8hyyr	4212	7	)	)	-RRB-
cord-006860-a3b8hyyr	4212	8	,	,	,
cord-006860-a3b8hyyr	4212	9	giving	give	VBG
cord-006860-a3b8hyyr	4212	10	a	a	DT
cord-006860-a3b8hyyr	4212	11	prevalence	prevalence	NN
cord-006860-a3b8hyyr	4212	12	of	of	IN
cord-006860-a3b8hyyr	4212	13	7.8	7.8	CD
cord-006860-a3b8hyyr	4212	14	%	%	NN
cord-006860-a3b8hyyr	4212	15	.	.	.
cord-006860-a3b8hyyr	4213	1	Severe	severe	JJ
cord-006860-a3b8hyyr	4213	2	FXII	FXII	NNP
cord-006860-a3b8hyyr	4213	3	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	4213	4	with	with	IN
cord-006860-a3b8hyyr	4213	5	FXII	FXII	NNP
cord-006860-a3b8hyyr	4213	6	:	:	:
cord-006860-a3b8hyyr	4214	1	C	C	NNP
cord-006860-a3b8hyyr	4214	2	below	below	IN
cord-006860-a3b8hyyr	4214	3	1	1	CD
cord-006860-a3b8hyyr	4214	4	%	%	NN
cord-006860-a3b8hyyr	4214	5	were	be	VBD
cord-006860-a3b8hyyr	4214	6	observed	observe	VBN
cord-006860-a3b8hyyr	4214	7	in	in	IN
cord-006860-a3b8hyyr	4214	8	7	7	CD
cord-006860-a3b8hyyr	4214	9	pts	pts	NN
cord-006860-a3b8hyyr	4214	10	..	..	.
cord-006860-a3b8hyyr	4215	1	ll5	ll5	NNP
cord-006860-a3b8hyyr	4215	2	pts=	pts=	NNP
cord-006860-a3b8hyyr	4215	3	proved	prove	VBD
cord-006860-a3b8hyyr	4215	4	to	to	TO
cord-006860-a3b8hyyr	4215	5	have	have	VB
cord-006860-a3b8hyyr	4215	6	moderate	moderate	JJ
cord-006860-a3b8hyyr	4215	7	FXII	FXII	NNP
cord-006860-a3b8hyyr	4215	8	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4215	9	with	with	IN
cord-006860-a3b8hyyr	4215	10	FXIhC	FXIhC	NNP
cord-006860-a3b8hyyr	4215	11	ranging	range	VBG
cord-006860-a3b8hyyr	4215	12	lrom	lrom	NNP
cord-006860-a3b8hyyr	4215	13	2	2	CD
cord-006860-a3b8hyyr	4215	14	to	to	IN
cord-006860-a3b8hyyr	4215	15	51	51	CD
cord-006860-a3b8hyyr	4215	16	%	%	NN
cord-006860-a3b8hyyr	4215	17	and	and	CC
cord-006860-a3b8hyyr	4215	18	FXII	FXII	NNP
cord-006860-a3b8hyyr	4215	19	:	:	:
cord-006860-a3b8hyyr	4216	1	Ag	Ag	NNP
cord-006860-a3b8hyyr	4216	2	ranging	range	VBG
cord-006860-a3b8hyyr	4216	3	from	from	IN
cord-006860-a3b8hyyr	4216	4	1	1	CD
cord-006860-a3b8hyyr	4216	5	to	to	IN
cord-006860-a3b8hyyr	4216	6	53	53	CD
cord-006860-a3b8hyyr	4216	7	%	%	NN
cord-006860-a3b8hyyr	4216	8	.	.	.
cord-006860-a3b8hyyr	4217	1	In	in	IN
cord-006860-a3b8hyyr	4217	2	none	none	NN
cord-006860-a3b8hyyr	4217	3	of	of	IN
cord-006860-a3b8hyyr	4217	4	them	-PRON-	PRP
cord-006860-a3b8hyyr	4217	5	inherited	inherit	VBN
cord-006860-a3b8hyyr	4217	6	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	4217	7	of	of	IN
cord-006860-a3b8hyyr	4217	8	other	other	JJ
cord-006860-a3b8hyyr	4217	9	well	well	RB
cord-006860-a3b8hyyr	4217	10	established	establish	VBN
cord-006860-a3b8hyyr	4217	11	thrombophila	thrombophila	IN
cord-006860-a3b8hyyr	4217	12	risk	risk	NN
cord-006860-a3b8hyyr	4217	13	factors	factor	NNS
cord-006860-a3b8hyyr	4217	14	could	could	MD
cord-006860-a3b8hyyr	4217	15	be	be	VB
cord-006860-a3b8hyyr	4217	16	detected	detect	VBN
cord-006860-a3b8hyyr	4217	17	.	.	.
cord-006860-a3b8hyyr	4218	1	None	none	NN
cord-006860-a3b8hyyr	4218	2	of	of	IN
cord-006860-a3b8hyyr	4218	3	the	the	DT
cord-006860-a3b8hyyr	4218	4	FXII	FXII	NNP
cord-006860-a3b8hyyr	4218	5	deficient	deficient	JJ
cord-006860-a3b8hyyr	4218	6	pts	pts	NN
cord-006860-a3b8hyyr	4218	7	.	.	.
cord-006860-a3b8hyyr	4219	1	had	have	VBD
cord-006860-a3b8hyyr	4219	2	positive	positive	JJ
cord-006860-a3b8hyyr	4219	3	lupus	lupus	NN
cord-006860-a3b8hyyr	4219	4	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	4219	5	tests	test	NNS
cord-006860-a3b8hyyr	4219	6	.	.	.
cord-006860-a3b8hyyr	4220	1	Familial	familial	JJ
cord-006860-a3b8hyyr	4220	2	FXII	FXII	NNP
cord-006860-a3b8hyyr	4220	3	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4220	4	was	be	VBD
cord-006860-a3b8hyyr	4220	5	found	find	VBN
cord-006860-a3b8hyyr	4220	6	m	m	NNP
cord-006860-a3b8hyyr	4220	7	9	9	CD
cord-006860-a3b8hyyr	4220	8	cases	case	NNS
cord-006860-a3b8hyyr	4220	9	.	.	.
cord-006860-a3b8hyyr	4221	1	Discussion	discussion	NN
cord-006860-a3b8hyyr	4221	2	and	and	CC
cord-006860-a3b8hyyr	4221	3	conclusion	conclusion	NN
cord-006860-a3b8hyyr	4221	4	:	:	:
cord-006860-a3b8hyyr	4222	1	The	the	DT
cord-006860-a3b8hyyr	4222	2	precedences	precedence	NNS
cord-006860-a3b8hyyr	4222	3	of	of	IN
cord-006860-a3b8hyyr	4222	4	FXII	FXII	NNP
cord-006860-a3b8hyyr	4222	5	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4222	6	amongpts	amongpts	IN
cord-006860-a3b8hyyr	4222	7	,	,	,
cord-006860-a3b8hyyr	4222	8	with	with	IN
cord-006860-a3b8hyyr	4222	9	venous	venous	JJ
cord-006860-a3b8hyyr	4222	10	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	4222	11	was	be	VBD
cord-006860-a3b8hyyr	4222	12	previously	previously	RB
cord-006860-a3b8hyyr	4222	13	described	describe	VBN
cord-006860-a3b8hyyr	4222	14	to	to	TO
cord-006860-a3b8hyyr	4222	15	be	be	VB
cord-006860-a3b8hyyr	4222	16	7.5	7.5	CD
cord-006860-a3b8hyyr	4222	17	-	-	SYM
cord-006860-a3b8hyyr	4222	18	10	10	CD
cord-006860-a3b8hyyr	4222	19	%	%	NN
cord-006860-a3b8hyyr	4222	20	.	.	.
cord-006860-a3b8hyyr	4223	1	Supporting	support	VBG
cord-006860-a3b8hyyr	4223	2	these	these	DT
cord-006860-a3b8hyyr	4223	3	data	datum	NNS
cord-006860-a3b8hyyr	4223	4	,	,	,
cord-006860-a3b8hyyr	4223	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	4223	6	have	have	VBP
cord-006860-a3b8hyyr	4223	7	shown	show	VBN
cord-006860-a3b8hyyr	4223	8	a	a	DT
cord-006860-a3b8hyyr	4223	9	praevalence	praevalence	NN
cord-006860-a3b8hyyr	4223	10	of	of	IN
cord-006860-a3b8hyyr	4223	11	FXII	FXII	NNP
cord-006860-a3b8hyyr	4223	12	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4223	13	of	of	IN
cord-006860-a3b8hyyr	4223	14	7.8	7.8	CD
cord-006860-a3b8hyyr	4223	15	%	%	NN
cord-006860-a3b8hyyr	4223	16	.	.	.
cord-006860-a3b8hyyr	4224	1	In	in	IN
cord-006860-a3b8hyyr	4224	2	comparison	comparison	NN
cord-006860-a3b8hyyr	4224	3	to	to	IN
cord-006860-a3b8hyyr	4224	4	the	the	DT
cord-006860-a3b8hyyr	4224	5	frequency	frequency	NN
cord-006860-a3b8hyyr	4224	6	of	of	IN
cord-006860-a3b8hyyr	4224	7	other	other	JJ
cord-006860-a3b8hyyr	4224	8	well	well	RB
cord-006860-a3b8hyyr	4224	9	established	establish	VBN
cord-006860-a3b8hyyr	4224	10	thrombophila	thrombophila	NN
cord-006860-a3b8hyyr	4224	11	risk	risk	NN
cord-006860-a3b8hyyr	4224	12	factors	factor	NNS
cord-006860-a3b8hyyr	4224	13	we	-PRON-	PRP
cord-006860-a3b8hyyr	4224	14	consequently	consequently	RB
cord-006860-a3b8hyyr	4224	15	have	have	VBP
cord-006860-a3b8hyyr	4224	16	observed	observe	VBN
cord-006860-a3b8hyyr	4224	17	a	a	DT
cord-006860-a3b8hyyr	4224	18	relatively	relatively	RB
cord-006860-a3b8hyyr	4224	19	high	high	JJ
cord-006860-a3b8hyyr	4224	20	prevalence	prevalence	NN
cord-006860-a3b8hyyr	4224	21	of	of	IN
cord-006860-a3b8hyyr	4224	22	FXII	FXII	NNP
cord-006860-a3b8hyyr	4224	23	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4224	24	m	m	NNP
cord-006860-a3b8hyyr	4224	25	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4224	26	study	study	NN
cord-006860-a3b8hyyr	4224	27	group	group	NN
cord-006860-a3b8hyyr	4224	28	.	.	.
cord-006860-a3b8hyyr	4225	1	These	these	DT
cord-006860-a3b8hyyr	4225	2	data	datum	NNS
cord-006860-a3b8hyyr	4225	3	,	,	,
cord-006860-a3b8hyyr	4225	4	from	from	IN
cord-006860-a3b8hyyr	4225	5	the	the	DT
cord-006860-a3b8hyyr	4225	6	largest	large	JJS
cord-006860-a3b8hyyr	4225	7	such	such	JJ
cord-006860-a3b8hyyr	4225	8	study	study	NN
cord-006860-a3b8hyyr	4225	9	reported	report	VBN
cord-006860-a3b8hyyr	4225	10	,	,	,
cord-006860-a3b8hyyr	4225	11	strongly	strongly	RB
cord-006860-a3b8hyyr	4225	12	indicate	indicate	VBP
cord-006860-a3b8hyyr	4225	13	that	that	IN
cord-006860-a3b8hyyr	4225	14	FXII	FXII	NNP
cord-006860-a3b8hyyr	4225	15	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4225	16	may	may	MD
cord-006860-a3b8hyyr	4225	17	not	not	RB
cord-006860-a3b8hyyr	4225	18	be	be	VB
cord-006860-a3b8hyyr	4225	19	a	a	DT
cord-006860-a3b8hyyr	4225	20	rare	rare	JJ
cord-006860-a3b8hyyr	4225	21	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4225	22	and	and	CC
cord-006860-a3b8hyyr	4225	23	may	may	MD
cord-006860-a3b8hyyr	4225	24	be	be	VB
cord-006860-a3b8hyyr	4225	25	more	more	RBR
cord-006860-a3b8hyyr	4225	26	frequently	frequently	RB
cord-006860-a3b8hyyr	4225	27	associated	associate	VBN
cord-006860-a3b8hyyr	4225	28	with	with	IN
cord-006860-a3b8hyyr	4225	29	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4225	30	than	than	IN
cord-006860-a3b8hyyr	4225	31	currently	currently	RB
cord-006860-a3b8hyyr	4225	32	suspected	suspect	VBN
cord-006860-a3b8hyyr	4225	33	.	.	.
cord-006860-a3b8hyyr	4226	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4226	2	describe	describe	VBP
cord-006860-a3b8hyyr	4226	3	a	a	DT
cord-006860-a3b8hyyr	4226	4	family	family	NN
cord-006860-a3b8hyyr	4226	5	with	with	IN
cord-006860-a3b8hyyr	4226	6	an	an	DT
cord-006860-a3b8hyyr	4226	7	exceptionally	exceptionally	RB
cord-006860-a3b8hyyr	4226	8	rare	rare	JJ
cord-006860-a3b8hyyr	4226	9	,	,	,
cord-006860-a3b8hyyr	4226	10	i.e.	i.e.	FW
cord-006860-a3b8hyyr	4226	11	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4226	12	,	,	,
cord-006860-a3b8hyyr	4226	13	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4226	14	,	,	,
cord-006860-a3b8hyyr	4226	15	combined	combine	VBN
cord-006860-a3b8hyyr	4226	16	with	with	IN
cord-006860-a3b8hyyr	4226	17	subnormal	subnormal	JJ
cord-006860-a3b8hyyr	4226	18	activities	activity	NNS
cord-006860-a3b8hyyr	4226	19	of	of	IN
cord-006860-a3b8hyyr	4226	20	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4226	21	factor	factor	NN
cord-006860-a3b8hyyr	4226	22	XII	XII	NNP
cord-006860-a3b8hyyr	4226	23	(	(	-LRB-
cord-006860-a3b8hyyr	4226	24	Hageman	Hageman	NNP
cord-006860-a3b8hyyr	4226	25	factor	factor	NN
cord-006860-a3b8hyyr	4226	26	)	)	-RRB-
cord-006860-a3b8hyyr	4226	27	.	.	.
cord-006860-a3b8hyyr	4227	1	The	the	DT
cord-006860-a3b8hyyr	4227	2	first	first	JJ
cord-006860-a3b8hyyr	4227	3	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	4227	4	event	event	NN
cord-006860-a3b8hyyr	4227	5	,	,	,
cord-006860-a3b8hyyr	4227	6	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	4227	7	embolism	embolism	NN
cord-006860-a3b8hyyr	4227	8	in	in	IN
cord-006860-a3b8hyyr	4227	9	the	the	DT
cord-006860-a3b8hyyr	4227	10	proposita	proposita	NN
cord-006860-a3b8hyyr	4227	11	was	be	VBD
cord-006860-a3b8hyyr	4227	12	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	4227	13	at	at	IN
cord-006860-a3b8hyyr	4227	14	age	age	NN
cord-006860-a3b8hyyr	4227	15	35	35	CD
cord-006860-a3b8hyyr	4227	16	.	.	.
cord-006860-a3b8hyyr	4228	1	Since	since	IN
cord-006860-a3b8hyyr	4228	2	that	that	DT
cord-006860-a3b8hyyr	4228	3	time	time	NN
cord-006860-a3b8hyyr	4228	4	,	,	,
cord-006860-a3b8hyyr	4228	5	'	'	''
cord-006860-a3b8hyyr	4228	6	spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	4228	7	'	'	''
cord-006860-a3b8hyyr	4228	8	venous	venous	JJ
cord-006860-a3b8hyyr	4228	9	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	4228	10	events	event	NNS
cord-006860-a3b8hyyr	4228	11	verified	verify	VBN
cord-006860-a3b8hyyr	4228	12	by	by	IN
cord-006860-a3b8hyyr	4228	13	phlebography	phlebography	NN
cord-006860-a3b8hyyr	4228	14	and	and	CC
cord-006860-a3b8hyyr	4228	15	perfusion	perfusion	NN
cord-006860-a3b8hyyr	4228	16	/	/	SYM
cord-006860-a3b8hyyr	4228	17	ventilation	ventilation	NN
cord-006860-a3b8hyyr	4228	18	lung	lung	NN
cord-006860-a3b8hyyr	4228	19	scan	scan	NN
cord-006860-a3b8hyyr	4228	20	recurred	recur	VBD
cord-006860-a3b8hyyr	4228	21	once	once	RB
cord-006860-a3b8hyyr	4228	22	every	every	DT
cord-006860-a3b8hyyr	4228	23	year	year	NN
cord-006860-a3b8hyyr	4228	24	despite	despite	IN
cord-006860-a3b8hyyr	4228	25	oral	oral	JJ
cord-006860-a3b8hyyr	4228	26	coumarin	coumarin	NN
cord-006860-a3b8hyyr	4228	27	therapy	therapy	NN
cord-006860-a3b8hyyr	4228	28	,	,	,
cord-006860-a3b8hyyr	4228	29	whose	whose	WP$
cord-006860-a3b8hyyr	4228	30	intensity	intensity	NN
cord-006860-a3b8hyyr	4228	31	varied	vary	VBN
cord-006860-a3b8hyyr	4228	32	over	over	IN
cord-006860-a3b8hyyr	4228	33	an	an	DT
cord-006860-a3b8hyyr	4228	34	exceptionally	exceptionally	RB
cord-006860-a3b8hyyr	4228	35	wide	wide	JJ
cord-006860-a3b8hyyr	4228	36	range	range	NN
cord-006860-a3b8hyyr	4228	37	despite	despite	IN
cord-006860-a3b8hyyr	4228	38	tight	tight	JJ
cord-006860-a3b8hyyr	4228	39	control	control	NN
cord-006860-a3b8hyyr	4228	40	The	the	DT
cord-006860-a3b8hyyr	4228	41	patient	patient	NN
cord-006860-a3b8hyyr	4228	42	was	be	VBD
cord-006860-a3b8hyyr	4228	43	repeatedly	repeatedly	RB
cord-006860-a3b8hyyr	4228	44	given	give	VBN
cord-006860-a3b8hyyr	4228	45	succesful	succesful	JJ
cord-006860-a3b8hyyr	4228	46	thrombolytic	thrombolytic	NN
cord-006860-a3b8hyyr	4228	47	therapy	therapy	NN
cord-006860-a3b8hyyr	4228	48	with	with	IN
cord-006860-a3b8hyyr	4228	49	streptokinase	streptokinase	NNP
cord-006860-a3b8hyyr	4228	50	or	or	CC
cord-006860-a3b8hyyr	4228	51	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	4228	52	tissue	tissue	NN
cord-006860-a3b8hyyr	4228	53	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4228	54	activator	activator	NN
cord-006860-a3b8hyyr	4228	55	.	.	.
cord-006860-a3b8hyyr	4229	1	Her	-PRON-	PRP$
cord-006860-a3b8hyyr	4229	2	plasma	plasma	NN
cord-006860-a3b8hyyr	4229	3	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4229	4	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	4229	5	activity	activity	NN
cord-006860-a3b8hyyr	4229	6	was	be	VBD
cord-006860-a3b8hyyr	4229	7	51	51	CD
cord-006860-a3b8hyyr	4229	8	-	-	SYM
cord-006860-a3b8hyyr	4229	9	59	59	CD
cord-006860-a3b8hyyr	4229	10	%	%	NN
cord-006860-a3b8hyyr	4229	11	compared	compare	VBN
cord-006860-a3b8hyyr	4229	12	to	to	IN
cord-006860-a3b8hyyr	4229	13	a	a	DT
cord-006860-a3b8hyyr	4229	14	normal	normal	JJ
cord-006860-a3b8hyyr	4229	15	plasma	plasma	NN
cord-006860-a3b8hyyr	4229	16	pool	pool	NN
cord-006860-a3b8hyyr	4229	17	(	(	-LRB-
cord-006860-a3b8hyyr	4229	18	reference	reference	NN
cord-006860-a3b8hyyr	4229	19	range	range	NN
cord-006860-a3b8hyyr	4229	20	70	70	CD
cord-006860-a3b8hyyr	4229	21	-	-	SYM
cord-006860-a3b8hyyr	4229	22	130	130	CD
cord-006860-a3b8hyyr	4229	23	%	%	NN
cord-006860-a3b8hyyr	4229	24	)	)	-RRB-
cord-006860-a3b8hyyr	4229	25	,	,	,
cord-006860-a3b8hyyr	4229	26	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4229	27	antigen	antigen	NN
cord-006860-a3b8hyyr	4229	28	was	be	VBD
cord-006860-a3b8hyyr	4229	29	diminished	diminish	VBN
cord-006860-a3b8hyyr	4229	30	to	to	IN
cord-006860-a3b8hyyr	4229	31	the	the	DT
cord-006860-a3b8hyyr	4229	32	same	same	JJ
cord-006860-a3b8hyyr	4229	33	extent	extent	NN
cord-006860-a3b8hyyr	4229	34	.	.	.
cord-006860-a3b8hyyr	4230	1	The	the	DT
cord-006860-a3b8hyyr	4230	2	patient	patient	NN
cord-006860-a3b8hyyr	4230	3	's	's	POS
cord-006860-a3b8hyyr	4230	4	factor	factor	NN
cord-006860-a3b8hyyr	4230	5	XII	XII	NNP
cord-006860-a3b8hyyr	4230	6	exhibited	exhibit	VBD
cord-006860-a3b8hyyr	4230	7	only	only	RB
cord-006860-a3b8hyyr	4230	8	28	28	CD
cord-006860-a3b8hyyr	4230	9	-	-	SYM
cord-006860-a3b8hyyr	4230	10	55	55	CD
cord-006860-a3b8hyyr	4230	11	%	%	NN
cord-006860-a3b8hyyr	4230	12	activity	activity	NN
cord-006860-a3b8hyyr	4230	13	in	in	IN
cord-006860-a3b8hyyr	4230	14	a	a	DT
cord-006860-a3b8hyyr	4230	15	factor	factor	NN
cord-006860-a3b8hyyr	4230	16	-	-	HYPH
cord-006860-a3b8hyyr	4230	17	deficient	deficient	JJ
cord-006860-a3b8hyyr	4230	18	plasma	plasma	NN
cord-006860-a3b8hyyr	4230	19	assay	assay	NN
cord-006860-a3b8hyyr	4230	20	as	as	IN
cord-006860-a3b8hyyr	4230	21	compared	compare	VBN
cord-006860-a3b8hyyr	4230	22	to	to	IN
cord-006860-a3b8hyyr	4230	23	a	a	DT
cord-006860-a3b8hyyr	4230	24	normal	normal	JJ
cord-006860-a3b8hyyr	4230	25	plasma	plasma	NN
cord-006860-a3b8hyyr	4230	26	pool	pool	NN
cord-006860-a3b8hyyr	4230	27	.	.	.
cord-006860-a3b8hyyr	4231	1	Other	other	JJ
cord-006860-a3b8hyyr	4231	2	known	know	VBN
cord-006860-a3b8hyyr	4231	3	risk	risk	NN
cord-006860-a3b8hyyr	4231	4	factors	factor	NNS
cord-006860-a3b8hyyr	4231	5	for	for	IN
cord-006860-a3b8hyyr	4231	6	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	4231	7	venous	venous	JJ
cord-006860-a3b8hyyr	4231	8	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	4231	9	were	be	VBD
cord-006860-a3b8hyyr	4231	10	not	not	RB
cord-006860-a3b8hyyr	4231	11	present	present	JJ
cord-006860-a3b8hyyr	4231	12	:	:	:
cord-006860-a3b8hyyr	4232	1	no	no	DT
cord-006860-a3b8hyyr	4232	2	evidence	evidence	NN
cord-006860-a3b8hyyr	4232	3	of	of	IN
cord-006860-a3b8hyyr	4232	4	malignancy	malignancy	NN
cord-006860-a3b8hyyr	4232	5	,	,	,
cord-006860-a3b8hyyr	4232	6	no	no	DT
cord-006860-a3b8hyyr	4232	7	obvious	obvious	JJ
cord-006860-a3b8hyyr	4232	8	precipitating	precipitate	VBG
cord-006860-a3b8hyyr	4232	9	events	event	NNS
cord-006860-a3b8hyyr	4232	10	,	,	,
cord-006860-a3b8hyyr	4232	11	normal	normal	JJ
cord-006860-a3b8hyyr	4232	12	values	value	NNS
cord-006860-a3b8hyyr	4232	13	of	of	IN
cord-006860-a3b8hyyr	4232	14	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	4232	15	III	III	NNP
cord-006860-a3b8hyyr	4232	16	,	,	,
cord-006860-a3b8hyyr	4232	17	protein	protein	NN
cord-006860-a3b8hyyr	4232	18	C	C	NNP
cord-006860-a3b8hyyr	4232	19	,	,	,
cord-006860-a3b8hyyr	4232	20	protein	protein	NN
cord-006860-a3b8hyyr	4232	21	S	S	NNP
cord-006860-a3b8hyyr	4232	22	,	,	,
cord-006860-a3b8hyyr	4232	23	fihrinogen	fihrinogen	NN
cord-006860-a3b8hyyr	4232	24	,	,	,
cord-006860-a3b8hyyr	4233	1	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	4233	2	time	time	NN
cord-006860-a3b8hyyr	4233	3	,	,	,
cord-006860-a3b8hyyr	4233	4	platelets	platelet	NNS
cord-006860-a3b8hyyr	4233	5	,	,	,
cord-006860-a3b8hyyr	4233	6	lupus	lupus	NN
cord-006860-a3b8hyyr	4233	7	-	-	HYPH
cord-006860-a3b8hyyr	4233	8	like	like	JJ
cord-006860-a3b8hyyr	4233	9	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	4233	10	,	,	.
cord-006860-a3b8hyyr	4234	1	aPTT	aptt	CD
cord-006860-a3b8hyyr	4234	2	prolongation	prolongation	NN
cord-006860-a3b8hyyr	4234	3	after	after	IN
cord-006860-a3b8hyyr	4234	4	addition	addition	NN
cord-006860-a3b8hyyr	4234	5	of	of	IN
cord-006860-a3b8hyyr	4234	6	activated	activate	VBN
cord-006860-a3b8hyyr	4234	7	protein	protein	NN
cord-006860-a3b8hyyr	4234	8	C.	C.	NNP
cord-006860-a3b8hyyr	4235	1	The	the	DT
cord-006860-a3b8hyyr	4235	2	proposita	proposita	NN
cord-006860-a3b8hyyr	4235	3	's	's	POS
cord-006860-a3b8hyyr	4235	4	mother	mother	NN
cord-006860-a3b8hyyr	4235	5	had	have	VBD
cord-006860-a3b8hyyr	4235	6	died	die	VBN
cord-006860-a3b8hyyr	4235	7	at	at	IN
cord-006860-a3b8hyyr	4235	8	age	age	NN
cord-006860-a3b8hyyr	4235	9	60	60	CD
cord-006860-a3b8hyyr	4235	10	from	from	IN
cord-006860-a3b8hyyr	4235	11	pulmonary	pulmonary	JJ
cord-006860-a3b8hyyr	4235	12	embolisnt	embolisnt	NN
cord-006860-a3b8hyyr	4236	1	No	no	DT
cord-006860-a3b8hyyr	4236	2	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4236	3	studies	study	NNS
cord-006860-a3b8hyyr	4236	4	are	be	VBP
cord-006860-a3b8hyyr	4236	5	available	available	JJ
cord-006860-a3b8hyyr	4236	6	.	.	.
cord-006860-a3b8hyyr	4237	1	The	the	DT
cord-006860-a3b8hyyr	4237	2	proposita	proposita	NN
cord-006860-a3b8hyyr	4237	3	's	's	POS
cord-006860-a3b8hyyr	4237	4	sister	sister	NN
cord-006860-a3b8hyyr	4237	5	was	be	VBD
cord-006860-a3b8hyyr	4237	6	first	first	RB
cord-006860-a3b8hyyr	4237	7	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	4237	8	deep	deep	JJ
cord-006860-a3b8hyyr	4237	9	leg	leg	NN
cord-006860-a3b8hyyr	4237	10	vein	vein	NN
cord-006860-a3b8hyyr	4237	11	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4237	12	at	at	IN
cord-006860-a3b8hyyr	4237	13	age	age	NN
cord-006860-a3b8hyyr	4237	14	17	17	CD
cord-006860-a3b8hyyr	4237	15	,	,	,
cord-006860-a3b8hyyr	4237	16	since	since	IN
cord-006860-a3b8hyyr	4237	17	that	that	DT
cord-006860-a3b8hyyr	4237	18	time	time	NN
cord-006860-a3b8hyyr	4237	19	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	4237	20	episodes	episode	NNS
cord-006860-a3b8hyyr	4237	21	of	of	IN
cord-006860-a3b8hyyr	4237	22	venous	venous	JJ
cord-006860-a3b8hyyr	4237	23	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	4237	24	have	have	VBP
cord-006860-a3b8hyyr	4237	25	been	be	VBN
cord-006860-a3b8hyyr	4237	26	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	4237	27	also	also	RB
cord-006860-a3b8hyyr	4237	28	in	in	IN
cord-006860-a3b8hyyr	4237	29	an	an	DT
cord-006860-a3b8hyyr	4237	30	other	other	JJ
cord-006860-a3b8hyyr	4237	31	hospital	hospital	NN
cord-006860-a3b8hyyr	4237	32	.	.	.
cord-006860-a3b8hyyr	4238	1	This	this	DT
cord-006860-a3b8hyyr	4238	2	sister	sister	NN
cord-006860-a3b8hyyr	4238	3	's	's	POS
cord-006860-a3b8hyyr	4238	4	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4238	5	activity	activity	NN
cord-006860-a3b8hyyr	4238	6	was	be	VBD
cord-006860-a3b8hyyr	4238	7	120	120	CD
cord-006860-a3b8hyyr	4238	8	%	%	NN
cord-006860-a3b8hyyr	4238	9	,	,	,
cord-006860-a3b8hyyr	4238	10	but	but	CC
cord-006860-a3b8hyyr	4238	11	factor	factor	NN
cord-006860-a3b8hyyr	4238	12	XII	XII	NNP
cord-006860-a3b8hyyr	4238	13	activity	activity	NN
cord-006860-a3b8hyyr	4238	14	was	be	VBD
cord-006860-a3b8hyyr	4238	15	reduced	reduce	VBN
cord-006860-a3b8hyyr	4238	16	to	to	IN
cord-006860-a3b8hyyr	4238	17	55	55	CD
cord-006860-a3b8hyyr	4238	18	%	%	NN
cord-006860-a3b8hyyr	4238	19	.	.	.
cord-006860-a3b8hyyr	4239	1	Three	three	CD
cord-006860-a3b8hyyr	4239	2	brothers	brother	NNS
cord-006860-a3b8hyyr	4239	3	of	of	IN
cord-006860-a3b8hyyr	4239	4	the	the	DT
cord-006860-a3b8hyyr	4239	5	proposita	proposita	NNP
cord-006860-a3b8hyyr	4239	6	were	be	VBD
cord-006860-a3b8hyyr	4239	7	examined	examine	VBN
cord-006860-a3b8hyyr	4239	8	,	,	,
cord-006860-a3b8hyyr	4239	9	too	too	RB
cord-006860-a3b8hyyr	4239	10	,	,	,
cord-006860-a3b8hyyr	4239	11	all	all	DT
cord-006860-a3b8hyyr	4239	12	in	in	IN
cord-006860-a3b8hyyr	4239	13	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4239	14	3rd	3rd	JJ
cord-006860-a3b8hyyr	4239	15	decade	decade	NN
cord-006860-a3b8hyyr	4239	16	of	of	IN
cord-006860-a3b8hyyr	4239	17	life	life	NN
cord-006860-a3b8hyyr	4239	18	.	.	.
cord-006860-a3b8hyyr	4240	1	None	none	NN
cord-006860-a3b8hyyr	4240	2	of	of	IN
cord-006860-a3b8hyyr	4240	3	them	-PRON-	PRP
cord-006860-a3b8hyyr	4240	4	recalled	recall	VBD
cord-006860-a3b8hyyr	4240	5	symptoms	symptom	NNS
cord-006860-a3b8hyyr	4240	6	of	of	IN
cord-006860-a3b8hyyr	4240	7	or	or	CC
cord-006860-a3b8hyyr	4240	8	treatment	treatment	NN
cord-006860-a3b8hyyr	4240	9	for	for	IN
cord-006860-a3b8hyyr	4240	10	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	4240	11	disease	disease	NN
cord-006860-a3b8hyyr	4240	12	.	.	.
cord-006860-a3b8hyyr	4241	1	In	in	IN
cord-006860-a3b8hyyr	4241	2	one	one	CD
cord-006860-a3b8hyyr	4241	3	brother	brother	NN
cord-006860-a3b8hyyr	4241	4	,	,	,
cord-006860-a3b8hyyr	4241	5	factor	factor	NN
cord-006860-a3b8hyyr	4241	6	XII	XII	NNP
cord-006860-a3b8hyyr	4241	7	activity	activity	NN
cord-006860-a3b8hyyr	4241	8	was	be	VBD
cord-006860-a3b8hyyr	4241	9	normal	normal	JJ
cord-006860-a3b8hyyr	4241	10	(	(	-LRB-
cord-006860-a3b8hyyr	4241	11	100	100	CD
cord-006860-a3b8hyyr	4241	12	-	-	SYM
cord-006860-a3b8hyyr	4241	13	105	105	CD
cord-006860-a3b8hyyr	4241	14	%	%	NN
cord-006860-a3b8hyyr	4241	15	)	)	-RRB-
cord-006860-a3b8hyyr	4241	16	,	,	,
cord-006860-a3b8hyyr	4241	17	but	but	CC
cord-006860-a3b8hyyr	4241	18	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4241	19	only	only	RB
cord-006860-a3b8hyyr	4241	20	about	about	IN
cord-006860-a3b8hyyr	4241	21	50	50	CD
cord-006860-a3b8hyyr	4241	22	%	%	NN
cord-006860-a3b8hyyr	4241	23	.	.	.
cord-006860-a3b8hyyr	4242	1	In	in	IN
cord-006860-a3b8hyyr	4242	2	the	the	DT
cord-006860-a3b8hyyr	4242	3	2nd	2nd	JJ
cord-006860-a3b8hyyr	4242	4	brother	brother	NN
cord-006860-a3b8hyyr	4242	5	,	,	,
cord-006860-a3b8hyyr	4242	6	factor	factor	NN
cord-006860-a3b8hyyr	4242	7	XII	XII	NNP
cord-006860-a3b8hyyr	4242	8	was	be	VBD
cord-006860-a3b8hyyr	4242	9	very	very	RB
cord-006860-a3b8hyyr	4242	10	variable	variable	JJ
cord-006860-a3b8hyyr	4242	11	(	(	-LRB-
cord-006860-a3b8hyyr	4242	12	64	64	CD
cord-006860-a3b8hyyr	4242	13	,	,	,
cord-006860-a3b8hyyr	4242	14	42	42	CD
cord-006860-a3b8hyyr	4242	15	and	and	CC
cord-006860-a3b8hyyr	4242	16	94	94	CD
cord-006860-a3b8hyyr	4242	17	%	%	NN
cord-006860-a3b8hyyr	4242	18	)	)	-RRB-
cord-006860-a3b8hyyr	4242	19	,	,	,
cord-006860-a3b8hyyr	4242	20	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4242	21	was	be	VBD
cord-006860-a3b8hyyr	4242	22	in	in	IN
cord-006860-a3b8hyyr	4242	23	the	the	DT
cord-006860-a3b8hyyr	4242	24	lower	low	JJR
cord-006860-a3b8hyyr	4242	25	normal	normal	JJ
cord-006860-a3b8hyyr	4242	26	range	range	NN
cord-006860-a3b8hyyr	4242	27	,	,	,
cord-006860-a3b8hyyr	4243	1	In	in	IN
cord-006860-a3b8hyyr	4243	2	the	the	DT
cord-006860-a3b8hyyr	4243	3	3rd	3rd	JJ
cord-006860-a3b8hyyr	4243	4	brother	brother	NN
cord-006860-a3b8hyyr	4243	5	,	,	,
cord-006860-a3b8hyyr	4243	6	factor	factor	NN
cord-006860-a3b8hyyr	4243	7	XII	XII	NNP
cord-006860-a3b8hyyr	4243	8	was	be	VBD
cord-006860-a3b8hyyr	4243	9	about	about	RB
cord-006860-a3b8hyyr	4243	10	50	50	CD
cord-006860-a3b8hyyr	4243	11	%	%	NN
cord-006860-a3b8hyyr	4243	12	(	(	-LRB-
cord-006860-a3b8hyyr	4243	13	repeatedly	repeatedly	RB
cord-006860-a3b8hyyr	4243	14	)	)	-RRB-
cord-006860-a3b8hyyr	4243	15	,	,	,
cord-006860-a3b8hyyr	4243	16	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4243	17	was	be	VBD
cord-006860-a3b8hyyr	4243	18	normal	normal	JJ
cord-006860-a3b8hyyr	4243	19	.	.	.
cord-006860-a3b8hyyr	4244	1	Current	current	JJ
cord-006860-a3b8hyyr	4244	2	knowledge	knowledge	NN
cord-006860-a3b8hyyr	4244	3	about	about	IN
cord-006860-a3b8hyyr	4244	4	the	the	DT
cord-006860-a3b8hyyr	4244	5	risk	risk	NN
cord-006860-a3b8hyyr	4244	6	of	of	IN
cord-006860-a3b8hyyr	4244	7	thromboembolism	thromboembolism	NN
cord-006860-a3b8hyyr	4244	8	with	with	IN
cord-006860-a3b8hyyr	4244	9	both	both	DT
cord-006860-a3b8hyyr	4244	10	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	4244	11	is	be	VBZ
cord-006860-a3b8hyyr	4244	12	limited	limit	VBN
cord-006860-a3b8hyyr	4244	13	,	,	,
cord-006860-a3b8hyyr	4244	14	the	the	DT
cord-006860-a3b8hyyr	4244	15	optimal	optimal	JJ
cord-006860-a3b8hyyr	4244	16	management	management	NN
cord-006860-a3b8hyyr	4244	17	remains	remain	VBZ
cord-006860-a3b8hyyr	4244	18	controversial	controversial	JJ
cord-006860-a3b8hyyr	4244	19	.	.	.
cord-006860-a3b8hyyr	4245	1	Msrgit	Msrgit	NNP
cord-006860-a3b8hyyr	4245	2	Serbsn	Serbsn	NNP
cord-006860-a3b8hyyr	4245	3	,	,	,
cord-006860-a3b8hyyr	4245	4	Maria	Maria	NNP
cord-006860-a3b8hyyr	4245	5	Cucuruz	Cucuruz	NNP
cord-006860-a3b8hyyr	4245	6	,	,	,
cord-006860-a3b8hyyr	4245	7	Dan	Dan	NNP
cord-006860-a3b8hyyr	4245	8	Madras	Madras	NNP
cord-006860-a3b8hyyr	4245	9	,	,	,
cord-006860-a3b8hyyr	4245	10	Carmen	Carmen	NNP
cord-006860-a3b8hyyr	4245	11	Petrescu	Petrescu	NNP
cord-006860-a3b8hyyr	4245	12	,	,	,
cord-006860-a3b8hyyr	4245	13	Natalie	Natalie	NNP
cord-006860-a3b8hyyr	4245	14	Rosiu	Rosiu	NNP
cord-006860-a3b8hyyr	4245	15	,	,	,
cord-006860-a3b8hyyr	4245	16	Rodica	Rodica	NNP
cord-006860-a3b8hyyr	4245	17	Costa	Costa	NNP
cord-006860-a3b8hyyr	4245	18	III	III	NNP
cord-006860-a3b8hyyr	4245	19	rd	rd	NNP
cord-006860-a3b8hyyr	4245	20	Psediatric	Psediatric	NNP
cord-006860-a3b8hyyr	4245	21	Clintc	Clintc	NNP
cord-006860-a3b8hyyr	4245	22	,	,	,
cord-006860-a3b8hyyr	4245	23	Universtt	Universtt	NNP
cord-006860-a3b8hyyr	4245	24	V	V	NNP
cord-006860-a3b8hyyr	4245	25	of	of	IN
cord-006860-a3b8hyyr	4245	26	Medicine	Medicine	NNP
cord-006860-a3b8hyyr	4245	27	,	,	,
cord-006860-a3b8hyyr	4245	28	The	the	DT
cord-006860-a3b8hyyr	4245	29	unsatisfactory	unsatisfactory	JJ
cord-006860-a3b8hyyr	4245	30	efficiency	efficiency	NN
cord-006860-a3b8hyyr	4245	31	of	of	IN
cord-006860-a3b8hyyr	4245	32	entihepetitis	entihepetitis	NNP
cord-006860-a3b8hyyr	4245	33	B	B	NNP
cord-006860-a3b8hyyr	4245	34	vaccination	vaccination	NN
cord-006860-a3b8hyyr	4245	35	in	in	IN
cord-006860-a3b8hyyr	4245	36	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4245	37	haemsphiliscs	haemsphiliscs	NNP
cord-006860-a3b8hyyr	4245	38	suggested	suggest	VBD
cord-006860-a3b8hyyr	4245	39	the	the	DT
cord-006860-a3b8hyyr	4245	40	control	control	NN
cord-006860-a3b8hyyr	4245	41	of	of	IN
cord-006860-a3b8hyyr	4245	42	the	the	DT
cord-006860-a3b8hyyr	4245	43	immune	immune	JJ
cord-006860-a3b8hyyr	4245	44	status	status	NN
cord-006860-a3b8hyyr	4245	45	in	in	IN
cord-006860-a3b8hyyr	4245	46	52	52	CD
cord-006860-a3b8hyyr	4245	47	HIV	HIV	NNP
cord-006860-a3b8hyyr	4245	48	negative	negative	JJ
cord-006860-a3b8hyyr	4245	49	patients	patient	NNS
cord-006860-a3b8hyyr	4245	50	,	,	,
cord-006860-a3b8hyyr	4245	51	by	by	IN
cord-006860-a3b8hyyr	4245	52	establishing	establish	VBG
cord-006860-a3b8hyyr	4245	53	through	through	IN
cord-006860-a3b8hyyr	4245	54	flowcitomstrie	flowcitomstrie	NNP
cord-006860-a3b8hyyr	4245	55	with	with	IN
cord-006860-a3b8hyyr	4245	56	monoclonsl	monoclonsl	NNP
cord-006860-a3b8hyyr	4245	57	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4245	58	the	the	DT
cord-006860-a3b8hyyr	4245	59	lymphocyte	lymphocyte	NN
cord-006860-a3b8hyyr	4245	60	subsets	subset	NNS
cord-006860-a3b8hyyr	4245	61	(	(	-LRB-
cord-006860-a3b8hyyr	4245	62	CD3,CD4,CDS	CD3,CD4,CDS	NNP
cord-006860-a3b8hyyr	4245	63	,	,	,
cord-006860-a3b8hyyr	4245	64	CD&/CD8	cd&/cd8	NN
cord-006860-a3b8hyyr	4245	65	ratio	ratio	NN
cord-006860-a3b8hyyr	4245	66	and	and	CC
cord-006860-a3b8hyyr	4245	67	CD19	CD19	NNP
cord-006860-a3b8hyyr	4245	68	)	)	-RRB-
cord-006860-a3b8hyyr	4245	69	and	and	CC
cord-006860-a3b8hyyr	4245	70	by	by	IN
cord-006860-a3b8hyyr	4245	71	seric	seric	NNP
cord-006860-a3b8hyyr	4245	72	tmmunoglobulins	tmmunoglobulins	NNP
cord-006860-a3b8hyyr	4245	73	levels	level	NNS
cord-006860-a3b8hyyr	4245	74	;	;	:
cord-006860-a3b8hyyr	4245	75	the	the	DT
cord-006860-a3b8hyyr	4245	76	immunological	immunological	JJ
cord-006860-a3b8hyyr	4245	77	parameters	parameter	NNS
cord-006860-a3b8hyyr	4245	78	have	have	VBP
cord-006860-a3b8hyyr	4245	79	been	be	VBN
cord-006860-a3b8hyyr	4245	80	correlated	correlate	VBN
cord-006860-a3b8hyyr	4245	81	with	with	IN
cord-006860-a3b8hyyr	4245	82	the	the	DT
cord-006860-a3b8hyyr	4245	83	serological	serological	JJ
cord-006860-a3b8hyyr	4245	84	markers	marker	NNS
cord-006860-a3b8hyyr	4245	85	of	of	IN
cord-006860-a3b8hyyr	4245	86	hepatitis	hepatitis	NN
cord-006860-a3b8hyyr	4245	87	infections	infection	NNS
cord-006860-a3b8hyyr	4245	88	(	(	-LRB-
cord-006860-a3b8hyyr	4245	89	HAY	HAY	NNP
cord-006860-a3b8hyyr	4245	90	,	,	,
cord-006860-a3b8hyyr	4245	91	HBV	HBV	NNP
cord-006860-a3b8hyyr	4245	92	,	,	,
cord-006860-a3b8hyyr	4245	93	HCV	HCV	NNP
cord-006860-a3b8hyyr	4245	94	ebd	ebd	NNP
cord-006860-a3b8hyyr	4245	95	HDV	HDV	NNP
cord-006860-a3b8hyyr	4245	96	)	)	-RRB-
cord-006860-a3b8hyyr	4245	97	as	as	RB
cord-006860-a3b8hyyr	4245	98	well	well	RB
cord-006860-a3b8hyyr	4245	99	as	as	IN
cord-006860-a3b8hyyr	4245	100	on	on	IN
cord-006860-a3b8hyyr	4245	101	dependence	dependence	NN
cord-006860-a3b8hyyr	4245	102	with	with	IN
cord-006860-a3b8hyyr	4245	103	the	the	DT
cord-006860-a3b8hyyr	4245	104	treatment	treatment	NN
cord-006860-a3b8hyyr	4245	105	(	(	-LRB-
cord-006860-a3b8hyyr	4245	106	blood	blood	NN
cord-006860-a3b8hyyr	4245	107	,	,	,
cord-006860-a3b8hyyr	4245	108	plasma	plasma	NN
cord-006860-a3b8hyyr	4245	109	,	,	,
cord-006860-a3b8hyyr	4245	110	crysprecipitate	crysprecipitate	NN
cord-006860-a3b8hyyr	4245	111	,	,	,
cord-006860-a3b8hyyr	4245	112	fector	fector	NNP
cord-006860-a3b8hyyr	4245	113	VIII	VIII	NNP
cord-006860-a3b8hyyr	4245	114	/	/	SYM
cord-006860-a3b8hyyr	4245	115	IX	IX	NNP
cord-006860-a3b8hyyr	4245	116	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4245	117	)	)	-RRB-
cord-006860-a3b8hyyr	4245	118	and	and	CC
cord-006860-a3b8hyyr	4245	119	the	the	DT
cord-006860-a3b8hyyr	4245	120	quantity	quantity	NN
cord-006860-a3b8hyyr	4245	121	of	of	IN
cord-006860-a3b8hyyr	4245	122	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4245	123	consumption	consumption	NN
cord-006860-a3b8hyyr	4245	124	(	(	-LRB-
cord-006860-a3b8hyyr	4245	125	UI	UI	NNP
cord-006860-a3b8hyyr	4245	126	/	/	SYM
cord-006860-a3b8hyyr	4245	127	k9	k9	NNP
cord-006860-a3b8hyyr	4245	128	weight/	weight/	NNP
cord-006860-a3b8hyyr	4246	1	yesr).The	yesr).the	NN
cord-006860-a3b8hyyr	4246	2	interpretation	interpretation	NN
cord-006860-a3b8hyyr	4246	3	of	of	IN
cord-006860-a3b8hyyr	4246	4	the	the	DT
cord-006860-a3b8hyyr	4246	5	results	result	NNS
cord-006860-a3b8hyyr	4246	6	pointed	point	VBD
cord-006860-a3b8hyyr	4246	7	out	out	RP
cord-006860-a3b8hyyr	4246	8	•	•	NN
cord-006860-a3b8hyyr	4246	9	significant	significant	JJ
cord-006860-a3b8hyyr	4246	10	lower	low	JJR
cord-006860-a3b8hyyr	4246	11	level	level	NN
cord-006860-a3b8hyyr	4246	12	of	of	IN
cord-006860-a3b8hyyr	4246	13	CD3,CD	cd3,cd	NN
cord-006860-a3b8hyyr	4246	14	&	&	CC
cord-006860-a3b8hyyr	4246	15	(	(	-LRB-
cord-006860-a3b8hyyr	4246	16	p	p	NN
cord-006860-a3b8hyyr	4246	17	<	<	XX
cord-006860-a3b8hyyr	4246	18	O	o	UH
cord-006860-a3b8hyyr	4246	19	,	,	,
cord-006860-a3b8hyyr	4246	20	O01	O01	NNP
cord-006860-a3b8hyyr	4246	21	)	)	-RRB-
cord-006860-a3b8hyyr	4246	22	st	st	NNP
cord-006860-a3b8hyyr	4247	1	the	the	DT
cord-006860-a3b8hyyr	4247	2	group	group	NN
cord-006860-a3b8hyyr	4247	3	of	of	IN
cord-006860-a3b8hyyr	4247	4	hsemophiliscs	hsemophiliscs	RB
cord-006860-a3b8hyyr	4247	5	treated	treat	VBN
cord-006860-a3b8hyyr	4247	6	with	with	IN
cord-006860-a3b8hyyr	4247	7	blood	blood	NN
cord-006860-a3b8hyyr	4247	8	,	,	,
cord-006860-a3b8hyyr	4247	9	plasma	plasma	NN
cord-006860-a3b8hyyr	4247	10	and	and	CC
cord-006860-a3b8hyyr	4247	11	cryopraclpitate	cryopraclpitate	NN
cord-006860-a3b8hyyr	4247	12	;	;	:
cord-006860-a3b8hyyr	4247	13	sdditionsly	sdditionsly	NNP
cord-006860-a3b8hyyr	4247	14	,	,	,
cord-006860-a3b8hyyr	4247	15	in	in	IN
cord-006860-a3b8hyyr	4247	16	this	this	DT
cord-006860-a3b8hyyr	4247	17	group	group	NN
cord-006860-a3b8hyyr	4247	18	of	of	IN
cord-006860-a3b8hyyr	4247	19	patients	patient	NNS
cord-006860-a3b8hyyr	4247	20	it	-PRON-	PRP
cord-006860-a3b8hyyr	4247	21	was	be	VBD
cord-006860-a3b8hyyr	4247	22	found	find	VBN
cord-006860-a3b8hyyr	4247	23	s	s	POS
cord-006860-a3b8hyyr	4247	24	significant	significant	JJ
cord-006860-a3b8hyyr	4247	25	drop	drop	NN
cord-006860-a3b8hyyr	4247	26	of	of	IN
cord-006860-a3b8hyyr	4247	27	the	the	DT
cord-006860-a3b8hyyr	4247	28	CD19	CD19	NNP
cord-006860-a3b8hyyr	4247	29	counts	count	VBZ
cord-006860-a3b8hyyr	4247	30	(	(	-LRB-
cord-006860-a3b8hyyr	4247	31	p	p	NN
cord-006860-a3b8hyyr	4247	32	<	<	XX
cord-006860-a3b8hyyr	4247	33	0,001	0,001	CD
cord-006860-a3b8hyyr	4247	34	)	)	-RRB-
cord-006860-a3b8hyyr	4247	35	without	without	IN
cord-006860-a3b8hyyr	4247	36	an	an	DT
cord-006860-a3b8hyyr	4247	37	immunoglobulin	immunoglobulin	NN
cord-006860-a3b8hyyr	4247	38	-	-	HYPH
cord-006860-a3b8hyyr	4247	39	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4247	40	.	.	.
cord-006860-a3b8hyyr	4248	1	The	the	DT
cord-006860-a3b8hyyr	4248	2	same	same	JJ
cord-006860-a3b8hyyr	4248	3	behaviour	behaviour	NN
cord-006860-a3b8hyyr	4248	4	was	be	VBD
cord-006860-a3b8hyyr	4248	5	found	find	VBN
cord-006860-a3b8hyyr	4248	6	at	at	IN
cord-006860-a3b8hyyr	4248	7	the	the	DT
cord-006860-a3b8hyyr	4248	8	group	group	NN
cord-006860-a3b8hyyr	4248	9	of	of	IN
cord-006860-a3b8hyyr	4248	10	haemophiliacs	haemophiliacs	NNP
cord-006860-a3b8hyyr	4248	11	carriers	carrier	NNS
cord-006860-a3b8hyyr	4248	12	of	of	IN
cord-006860-a3b8hyyr	4248	13	HB~	HB~	NNS
cord-006860-a3b8hyyr	4248	14	and	and	CC
cord-006860-a3b8hyyr	4248	15	HCV	HCV	NNP
cord-006860-a3b8hyyr	4248	16	markers	marker	NNS
cord-006860-a3b8hyyr	4248	17	.	.	.
cord-006860-a3b8hyyr	4249	1	The	the	DT
cord-006860-a3b8hyyr	4249	2	superpositisn	superpositisn	NN
cord-006860-a3b8hyyr	4249	3	of	of	IN
cord-006860-a3b8hyyr	4249	4	hepatitis	hepatitis	NN
cord-006860-a3b8hyyr	4249	5	infections	infection	NNS
cord-006860-a3b8hyyr	4249	6	on	on	IN
cord-006860-a3b8hyyr	4249	7	the	the	DT
cord-006860-a3b8hyyr	4249	8	treatment	treatment	NN
cord-006860-a3b8hyyr	4249	9	with	with	IN
cord-006860-a3b8hyyr	4249	10	blood	blood	NN
cord-006860-a3b8hyyr	4249	11	and	and	CC
cord-006860-a3b8hyyr	4249	12	native	native	JJ
cord-006860-a3b8hyyr	4249	13	blood	blood	NN
cord-006860-a3b8hyyr	4249	14	products	product	NNS
cord-006860-a3b8hyyr	4249	15	in	in	IN
cord-006860-a3b8hyyr	4249	16	most	most	JJS
cord-006860-a3b8hyyr	4249	17	of	of	IN
cord-006860-a3b8hyyr	4249	18	the	the	DT
cord-006860-a3b8hyyr	4249	19	cases	case	NNS
cord-006860-a3b8hyyr	4249	20	has	have	VBZ
cord-006860-a3b8hyyr	4249	21	let	let	VBN
cord-006860-a3b8hyyr	4249	22	unanswered	unanswered	JJ
cord-006860-a3b8hyyr	4249	23	the	the	DT
cord-006860-a3b8hyyr	4249	24	question	question	NN
cord-006860-a3b8hyyr	4249	25	related	relate	VBN
cord-006860-a3b8hyyr	4249	26	to	to	IN
cord-006860-a3b8hyyr	4249	27	the	the	DT
cord-006860-a3b8hyyr	4249	28	mechanism	mechanism	NN
cord-006860-a3b8hyyr	4249	29	of	of	IN
cord-006860-a3b8hyyr	4249	30	the	the	DT
cord-006860-a3b8hyyr	4249	31	immunodeficiency	immunodeficiency	NN
cord-006860-a3b8hyyr	4249	32	:	:	:
cord-006860-a3b8hyyr	4249	33	the	the	DT
cord-006860-a3b8hyyr	4249	34	hepatitis	hepatitis	NN
cord-006860-a3b8hyyr	4249	35	B	B	NNP
cord-006860-a3b8hyyr	4249	36	or	or	CC
cord-006860-a3b8hyyr	4249	37	C	C	NNP
cord-006860-a3b8hyyr	4249	38	infections	infection	NNS
cord-006860-a3b8hyyr	4249	39	or	or	CC
cord-006860-a3b8hyyr	4249	40	the	the	DT
cord-006860-a3b8hyyr	4249	41	negative	negative	JJ
cord-006860-a3b8hyyr	4249	42	impact	impact	NN
cord-006860-a3b8hyyr	4249	43	of	of	IN
cord-006860-a3b8hyyr	4249	44	the	the	DT
cord-006860-a3b8hyyr	4249	45	itarative	itarative	JJ
cord-006860-a3b8hyyr	4249	46	important	important	JJ
cord-006860-a3b8hyyr	4249	47	alloantigenlc	alloantigenlc	NN
cord-006860-a3b8hyyr	4249	48	load	load	NN
cord-006860-a3b8hyyr	4249	49	?	?	.
cord-006860-a3b8hyyr	4250	1	Illumination	illumination	NN
cord-006860-a3b8hyyr	4250	2	with	with	IN
cord-006860-a3b8hyyr	4250	3	l	l	NN
cord-006860-a3b8hyyr	4250	4	~	~	CD
cord-006860-a3b8hyyr	4250	5	tM	tM	NNP
cord-006860-a3b8hyyr	4250	6	methylenblue	methylenblue	NNS
cord-006860-a3b8hyyr	4250	7	(	(	-LRB-
cord-006860-a3b8hyyr	4250	8	MB	MB	NNP
cord-006860-a3b8hyyr	4250	9	)	)	-RRB-
cord-006860-a3b8hyyr	4250	10	is	be	VBZ
cord-006860-a3b8hyyr	4250	11	used	use	VBN
cord-006860-a3b8hyyr	4250	12	for	for	IN
cord-006860-a3b8hyyr	4250	13	inactivation	inactivation	NN
cord-006860-a3b8hyyr	4250	14	of	of	IN
cord-006860-a3b8hyyr	4250	15	enveloped	envelop	VBN
cord-006860-a3b8hyyr	4250	16	viruses	virus	NNS
cord-006860-a3b8hyyr	4250	17	in	in	IN
cord-006860-a3b8hyyr	4250	18	human	human	JJ
cord-006860-a3b8hyyr	4250	19	plasma	plasma	NN
cord-006860-a3b8hyyr	4250	20	.	.	.
cord-006860-a3b8hyyr	4251	1	Via	via	IN
cord-006860-a3b8hyyr	4251	2	a	a	DT
cord-006860-a3b8hyyr	4251	3	photooxidative	photooxidative	JJ
cord-006860-a3b8hyyr	4251	4	mechanism	mechanism	NN
cord-006860-a3b8hyyr	4251	5	viral	viral	JJ
cord-006860-a3b8hyyr	4251	6	structures	structure	NNS
cord-006860-a3b8hyyr	4251	7	as	as	RB
cord-006860-a3b8hyyr	4251	8	well	well	RB
cord-006860-a3b8hyyr	4251	9	as	as	IN
cord-006860-a3b8hyyr	4251	10	plasmaproteins	plasmaprotein	NNS
cord-006860-a3b8hyyr	4251	11	especially	especially	RB
cord-006860-a3b8hyyr	4251	12	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4251	13	can	can	MD
cord-006860-a3b8hyyr	4251	14	be	be	VB
cord-006860-a3b8hyyr	4251	15	damaged	damage	VBN
cord-006860-a3b8hyyr	4251	16	.	.	.
cord-006860-a3b8hyyr	4252	1	Fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4252	2	is	be	VBZ
cord-006860-a3b8hyyr	4252	3	an	an	DT
cord-006860-a3b8hyyr	4252	4	important	important	JJ
cord-006860-a3b8hyyr	4252	5	mediator	mediator	NN
cord-006860-a3b8hyyr	4252	6	in	in	IN
cord-006860-a3b8hyyr	4252	7	the	the	DT
cord-006860-a3b8hyyr	4252	8	cell	cell	NN
cord-006860-a3b8hyyr	4252	9	-	-	HYPH
cord-006860-a3b8hyyr	4252	10	cell	cell	NN
cord-006860-a3b8hyyr	4252	11	interaction	interaction	NN
cord-006860-a3b8hyyr	4252	12	of	of	IN
cord-006860-a3b8hyyr	4252	13	platelets	platelet	NNS
cord-006860-a3b8hyyr	4252	14	.	.	.
cord-006860-a3b8hyyr	4253	1	The	the	DT
cord-006860-a3b8hyyr	4253	2	four	four	CD
cord-006860-a3b8hyyr	4253	3	RGD	RGD	NNP
cord-006860-a3b8hyyr	4253	4	sequences	sequence	NNS
cord-006860-a3b8hyyr	4253	5	(	(	-LRB-
cord-006860-a3b8hyyr	4253	6	Arg	Arg	NNP
cord-006860-a3b8hyyr	4253	7	-	-	HYPH
cord-006860-a3b8hyyr	4253	8	Gly	Gly	NNP
cord-006860-a3b8hyyr	4253	9	-	-	HYPH
cord-006860-a3b8hyyr	4253	10	Asp	Asp	NNP
cord-006860-a3b8hyyr	4253	11	)	)	-RRB-
cord-006860-a3b8hyyr	4253	12	of	of	IN
cord-006860-a3b8hyyr	4253	13	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4253	14	can	can	MD
cord-006860-a3b8hyyr	4253	15	be	be	VB
cord-006860-a3b8hyyr	4253	16	recognized	recognize	VBN
cord-006860-a3b8hyyr	4253	17	by	by	IN
cord-006860-a3b8hyyr	4253	18	the	the	DT
cord-006860-a3b8hyyr	4253	19	activated	activate	VBN
cord-006860-a3b8hyyr	4253	20	fibrinogenreceptor	fibrinogenreceptor	NN
cord-006860-a3b8hyyr	4253	21	GPHb	GPHb	NNP
cord-006860-a3b8hyyr	4253	22	/	/	SYM
cord-006860-a3b8hyyr	4253	23	IIIa	IIIa	NNP
cord-006860-a3b8hyyr	4253	24	.	.	.
cord-006860-a3b8hyyr	4254	1	After	after	IN
cord-006860-a3b8hyyr	4254	2	binding	bind	VBG
cord-006860-a3b8hyyr	4254	3	to	to	IN
cord-006860-a3b8hyyr	4254	4	GPIIb	GPIIb	NNP
cord-006860-a3b8hyyr	4254	5	/	/	SYM
cord-006860-a3b8hyyr	4254	6	IIIa	IIIa	NNP
cord-006860-a3b8hyyr	4254	7	one	one	CD
cord-006860-a3b8hyyr	4254	8	molecule	molecule	NN
cord-006860-a3b8hyyr	4254	9	fibdnogen	fibdnogen	NNP
cord-006860-a3b8hyyr	4254	10	can	can	MD
cord-006860-a3b8hyyr	4254	11	link	link	VB
cord-006860-a3b8hyyr	4254	12	two	two	CD
cord-006860-a3b8hyyr	4254	13	platelets	platelet	NNS
cord-006860-a3b8hyyr	4254	14	.	.	.
cord-006860-a3b8hyyr	4255	1	The	the	DT
cord-006860-a3b8hyyr	4255	2	aim	aim	NN
cord-006860-a3b8hyyr	4255	3	of	of	IN
cord-006860-a3b8hyyr	4255	4	this	this	DT
cord-006860-a3b8hyyr	4255	5	study	study	NN
cord-006860-a3b8hyyr	4255	6	was	be	VBD
cord-006860-a3b8hyyr	4255	7	to	to	TO
cord-006860-a3b8hyyr	4255	8	investigate	investigate	VB
cord-006860-a3b8hyyr	4255	9	the	the	DT
cord-006860-a3b8hyyr	4255	10	influence	influence	NN
cord-006860-a3b8hyyr	4255	11	of	of	IN
cord-006860-a3b8hyyr	4255	12	MB	mb	NN
cord-006860-a3b8hyyr	4255	13	treatment	treatment	NN
cord-006860-a3b8hyyr	4255	14	on	on	IN
cord-006860-a3b8hyyr	4255	15	the	the	DT
cord-006860-a3b8hyyr	4255	16	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4255	17	activity	activity	NN
cord-006860-a3b8hyyr	4255	18	in	in	IN
cord-006860-a3b8hyyr	4255	19	human	human	JJ
cord-006860-a3b8hyyr	4255	20	plasma	plasma	NN
cord-006860-a3b8hyyr	4255	21	.	.	.
cord-006860-a3b8hyyr	4256	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	4256	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	4256	3	were	be	VBD
cord-006860-a3b8hyyr	4256	4	interested	interested	JJ
cord-006860-a3b8hyyr	4256	5	to	to	TO
cord-006860-a3b8hyyr	4256	6	demonstrate	demonstrate	VB
cord-006860-a3b8hyyr	4256	7	if	if	IN
cord-006860-a3b8hyyr	4256	8	altered	alter	VBN
cord-006860-a3b8hyyr	4256	9	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4256	10	inhibit	inhibit	NN
cord-006860-a3b8hyyr	4256	11	platelet	platelet	NN
cord-006860-a3b8hyyr	4256	12	aggregation	aggregation	NN
cord-006860-a3b8hyyr	4256	13	by	by	IN
cord-006860-a3b8hyyr	4256	14	blocking	block	VBG
cord-006860-a3b8hyyr	4256	15	the	the	DT
cord-006860-a3b8hyyr	4256	16	GPIIb/]IIa	GPIIb/]IIa	NNP
cord-006860-a3b8hyyr	4256	17	receptor	receptor	NN
cord-006860-a3b8hyyr	4256	18	.	.	.
cord-006860-a3b8hyyr	4257	1	Human	human	JJ
cord-006860-a3b8hyyr	4257	2	plasma	plasma	NN
cord-006860-a3b8hyyr	4257	3	was	be	VBD
cord-006860-a3b8hyyr	4257	4	treated	treat	VBN
cord-006860-a3b8hyyr	4257	5	with	with	IN
cord-006860-a3b8hyyr	4257	6	1	1	CD
cord-006860-a3b8hyyr	4257	7	-	-	SYM
cord-006860-a3b8hyyr	4257	8	50~M	50~m	CD
cord-006860-a3b8hyyr	4257	9	MB	mb	NN
cord-006860-a3b8hyyr	4257	10	.	.	.
cord-006860-a3b8hyyr	4258	1	After	after	IN
cord-006860-a3b8hyyr	4258	2	illumination	illumination	NN
cord-006860-a3b8hyyr	4258	3	fibdnogen	fibdnogen	NNP
cord-006860-a3b8hyyr	4258	4	was	be	VBD
cord-006860-a3b8hyyr	4258	5	isolated	isolate	VBN
cord-006860-a3b8hyyr	4258	6	by	by	IN
cord-006860-a3b8hyyr	4258	7	fl	fl	NNP
cord-006860-a3b8hyyr	4258	8	-	-	HYPH
cord-006860-a3b8hyyr	4258	9	alanin	alanin	NNP
cord-006860-a3b8hyyr	4258	10	precipitation	precipitation	NN
cord-006860-a3b8hyyr	4258	11	.	.	.
cord-006860-a3b8hyyr	4259	1	Purified	purify	VBN
cord-006860-a3b8hyyr	4259	2	fibdnogen	fibdnogen	NNP
cord-006860-a3b8hyyr	4259	3	was	be	VBD
cord-006860-a3b8hyyr	4259	4	analysed	analyse	VBN
cord-006860-a3b8hyyr	4259	5	by	by	IN
cord-006860-a3b8hyyr	4259	6	one	one	CD
cord-006860-a3b8hyyr	4259	7	-	-	HYPH
cord-006860-a3b8hyyr	4259	8	and	and	CC
cord-006860-a3b8hyyr	4259	9	twodimensional	twodimensional	NNP
cord-006860-a3b8hyyr	4259	10	gelelectrophoresis	gelelectrophoresis	NNP
cord-006860-a3b8hyyr	4259	11	.	.	.
cord-006860-a3b8hyyr	4260	1	Influence	influence	NN
cord-006860-a3b8hyyr	4260	2	of	of	IN
cord-006860-a3b8hyyr	4260	3	modified	modify	VBN
cord-006860-a3b8hyyr	4260	4	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4260	5	on	on	IN
cord-006860-a3b8hyyr	4260	6	platetet	platetet	NNP
cord-006860-a3b8hyyr	4260	7	aggregation	aggregation	NN
cord-006860-a3b8hyyr	4260	8	was	be	VBD
cord-006860-a3b8hyyr	4260	9	measured	measure	VBN
cord-006860-a3b8hyyr	4260	10	with	with	IN
cord-006860-a3b8hyyr	4260	11	gelfiltrated	gelfiltrated	JJ
cord-006860-a3b8hyyr	4260	12	platelets	platelet	NNS
cord-006860-a3b8hyyr	4260	13	.	.	.
cord-006860-a3b8hyyr	4261	1	Possible	possible	JJ
cord-006860-a3b8hyyr	4261	2	receptorblockade	receptorblockade	NN
cord-006860-a3b8hyyr	4261	3	were	be	VBD
cord-006860-a3b8hyyr	4261	4	examined	examine	VBN
cord-006860-a3b8hyyr	4261	5	in	in	IN
cord-006860-a3b8hyyr	4261	6	an	an	DT
cord-006860-a3b8hyyr	4261	7	125j	125j	CD
cord-006860-a3b8hyyr	4261	8	-	-	HYPH
cord-006860-a3b8hyyr	4261	9	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4261	10	competition	competition	NN
cord-006860-a3b8hyyr	4261	11	assay	assay	NN
cord-006860-a3b8hyyr	4261	12	.	.	.
cord-006860-a3b8hyyr	4262	1	Densitometric	densitometric	JJ
cord-006860-a3b8hyyr	4262	2	scanning	scanning	NN
cord-006860-a3b8hyyr	4262	3	of	of	IN
cord-006860-a3b8hyyr	4262	4	reduced	reduce	VBN
cord-006860-a3b8hyyr	4262	5	SDS	SDS	NNP
cord-006860-a3b8hyyr	4262	6	-	-	HYPH
cord-006860-a3b8hyyr	4262	7	pages	page	NNS
cord-006860-a3b8hyyr	4262	8	showed	show	VBD
cord-006860-a3b8hyyr	4262	9	a	a	DT
cord-006860-a3b8hyyr	4262	10	decrease	decrease	NN
cord-006860-a3b8hyyr	4262	11	of	of	IN
cord-006860-a3b8hyyr	4262	12	the	the	DT
cord-006860-a3b8hyyr	4262	13	a	a	DT
cord-006860-a3b8hyyr	4262	14	-	-	HYPH
cord-006860-a3b8hyyr	4262	15	subunit	subunit	NN
cord-006860-a3b8hyyr	4262	16	as	as	RB
cord-006860-a3b8hyyr	4262	17	well	well	RB
cord-006860-a3b8hyyr	4262	18	as	as	IN
cord-006860-a3b8hyyr	4262	19	an	an	DT
cord-006860-a3b8hyyr	4262	20	increase	increase	NN
cord-006860-a3b8hyyr	4262	21	of	of	IN
cord-006860-a3b8hyyr	4262	22	high	high	JJ
cord-006860-a3b8hyyr	4262	23	molecular	molecular	JJ
cord-006860-a3b8hyyr	4262	24	aggregates	aggregate	NNS
cord-006860-a3b8hyyr	4262	25	with	with	IN
cord-006860-a3b8hyyr	4262	26	increased	increase	VBN
cord-006860-a3b8hyyr	4262	27	MB	mb	NN
cord-006860-a3b8hyyr	4262	28	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4262	29	.	.	.
cord-006860-a3b8hyyr	4263	1	This	this	DT
cord-006860-a3b8hyyr	4263	2	effect	effect	NN
cord-006860-a3b8hyyr	4263	3	was	be	VBD
cord-006860-a3b8hyyr	4263	4	not	not	RB
cord-006860-a3b8hyyr	4263	5	detectable	detectable	JJ
cord-006860-a3b8hyyr	4263	6	for	for	IN
cord-006860-a3b8hyyr	4263	7	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4263	8	isolated	isolate	VBN
cord-006860-a3b8hyyr	4263	9	from	from	IN
cord-006860-a3b8hyyr	4263	10	plasma	plasma	NN
cord-006860-a3b8hyyr	4263	11	with	with	IN
cord-006860-a3b8hyyr	4263	12	1BM	1bm	CD
cord-006860-a3b8hyyr	4263	13	MB	mb	NN
cord-006860-a3b8hyyr	4263	14	.	.	.
cord-006860-a3b8hyyr	4264	1	This	this	DT
cord-006860-a3b8hyyr	4264	2	results	result	NNS
cord-006860-a3b8hyyr	4264	3	were	be	VBD
cord-006860-a3b8hyyr	4264	4	confirmed	confirm	VBN
cord-006860-a3b8hyyr	4264	5	by	by	IN
cord-006860-a3b8hyyr	4264	6	two	two	CD
cord-006860-a3b8hyyr	4264	7	-	-	HYPH
cord-006860-a3b8hyyr	4264	8	dimensional	dimensional	JJ
cord-006860-a3b8hyyr	4264	9	gelelectrophoresis	gelelectrophoresis	NN
cord-006860-a3b8hyyr	4264	10	.	.	.
cord-006860-a3b8hyyr	4265	1	IBM	IBM	NNP
cord-006860-a3b8hyyr	4265	2	MB	MB	NNP
cord-006860-a3b8hyyr	4265	3	treatment	treatment	NN
cord-006860-a3b8hyyr	4265	4	showed	show	VBD
cord-006860-a3b8hyyr	4265	5	no	no	DT
cord-006860-a3b8hyyr	4265	6	receptor	receptor	NN
cord-006860-a3b8hyyr	4265	7	blockade	blockade	NN
cord-006860-a3b8hyyr	4265	8	in	in	IN
cord-006860-a3b8hyyr	4265	9	aggrement	aggrement	NN
cord-006860-a3b8hyyr	4265	10	with	with	IN
cord-006860-a3b8hyyr	4265	11	normal	normal	JJ
cord-006860-a3b8hyyr	4265	12	platelet	platelet	NN
cord-006860-a3b8hyyr	4265	13	aggregation	aggregation	NN
cord-006860-a3b8hyyr	4265	14	after	after	IN
cord-006860-a3b8hyyr	4265	15	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4265	16	with	with	IN
cord-006860-a3b8hyyr	4265	17	ADP	ADP	NNP
cord-006860-a3b8hyyr	4265	18	and	and	CC
cord-006860-a3b8hyyr	4265	19	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4265	20	.	.	.
cord-006860-a3b8hyyr	4266	1	PROPOSED	proposed	NN
cord-006860-a3b8hyyr	4266	2	VALIDATION	validation	NN
cord-006860-a3b8hyyr	4266	3	OF	of	IN
cord-006860-a3b8hyyr	4266	4	A	a	DT
cord-006860-a3b8hyyr	4266	5	QUANTITIVE	QUANTITIVE	NNP
cord-006860-a3b8hyyr	4266	6	QUALITY	quality	NN
cord-006860-a3b8hyyr	4266	7	-	-	HYPH
cord-006860-a3b8hyyr	4266	8	ASSURED	assure	VBN
cord-006860-a3b8hyyr	4266	9	PCR	pcr	NN
cord-006860-a3b8hyyr	4266	10	METHOD	method	NN
cord-006860-a3b8hyyr	4266	11	F.	F.	NNP
cord-006860-a3b8hyyr	4266	12	Dorner	Dorner	NNP
cord-006860-a3b8hyyr	4266	13	,	,	,
cord-006860-a3b8hyyr	4266	14	J.	J.	NNP
cord-006860-a3b8hyyr	4266	15	Eibl	Eibl	NNP
cord-006860-a3b8hyyr	4266	16	,	,	,
cord-006860-a3b8hyyr	4267	1	G.	G.	NNP
cord-006860-a3b8hyyr	4267	2	Zerlauth	Zerlauth	NNP
cord-006860-a3b8hyyr	4267	3	Immuno	Immuno	NNP
cord-006860-a3b8hyyr	4267	4	AG	AG	NNP
cord-006860-a3b8hyyr	4267	5	We	-PRON-	PRP
cord-006860-a3b8hyyr	4267	6	have	have	VBP
cord-006860-a3b8hyyr	4267	7	developed	develop	VBN
cord-006860-a3b8hyyr	4267	8	a	a	DT
cord-006860-a3b8hyyr	4267	9	highly	highly	RB
cord-006860-a3b8hyyr	4267	10	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	4267	11	and	and	CC
cord-006860-a3b8hyyr	4267	12	reliable	reliable	JJ
cord-006860-a3b8hyyr	4267	13	quantitative	quantitative	JJ
cord-006860-a3b8hyyr	4267	14	method	method	NN
cord-006860-a3b8hyyr	4267	15	,	,	,
cord-006860-a3b8hyyr	4267	16	based	base	VBN
cord-006860-a3b8hyyr	4267	17	on	on	IN
cord-006860-a3b8hyyr	4267	18	the	the	DT
cord-006860-a3b8hyyr	4267	19	polymerase	polymerase	NN
cord-006860-a3b8hyyr	4267	20	chain	chain	NN
cord-006860-a3b8hyyr	4267	21	reaction	reaction	NN
cord-006860-a3b8hyyr	4267	22	(	(	-LRB-
cord-006860-a3b8hyyr	4267	23	PCR	PCR	NNP
cord-006860-a3b8hyyr	4267	24	)	)	-RRB-
cord-006860-a3b8hyyr	4267	25	and	and	CC
cord-006860-a3b8hyyr	4267	26	on	on	IN
cord-006860-a3b8hyyr	4267	27	the	the	DT
cord-006860-a3b8hyyr	4267	28	reverse	reverse	JJ
cord-006860-a3b8hyyr	4267	29	transcriptase	transcriptase	NN
cord-006860-a3b8hyyr	4267	30	polymerase	polymerase	NN
cord-006860-a3b8hyyr	4267	31	chain	chain	NN
cord-006860-a3b8hyyr	4267	32	reaction	reaction	NN
cord-006860-a3b8hyyr	4267	33	(	(	-LRB-
cord-006860-a3b8hyyr	4267	34	RT	RT	NNP
cord-006860-a3b8hyyr	4267	35	-	-	HYPH
cord-006860-a3b8hyyr	4267	36	PCR	PCR	NNP
cord-006860-a3b8hyyr	4267	37	)	)	-RRB-
cord-006860-a3b8hyyr	4267	38	,	,	,
cord-006860-a3b8hyyr	4267	39	to	to	TO
cord-006860-a3b8hyyr	4267	40	screen	screen	VB
cord-006860-a3b8hyyr	4267	41	for	for	IN
cord-006860-a3b8hyyr	4267	42	the	the	DT
cord-006860-a3b8hyyr	4267	43	nucleic	nucleic	JJ
cord-006860-a3b8hyyr	4267	44	acids	acid	NNS
cord-006860-a3b8hyyr	4267	45	of	of	IN
cord-006860-a3b8hyyr	4267	46	Human	Human	NNP
cord-006860-a3b8hyyr	4267	47	Immunodeficiency	Immunodeficiency	NNP
cord-006860-a3b8hyyr	4267	48	Virus	Virus	NNP
cord-006860-a3b8hyyr	4267	49	type	type	NN
cord-006860-a3b8hyyr	4267	50	1	1	CD
cord-006860-a3b8hyyr	4267	51	(	(	-LRB-
cord-006860-a3b8hyyr	4267	52	HIV	HIV	NNP
cord-006860-a3b8hyyr	4267	53	-	-	HYPH
cord-006860-a3b8hyyr	4267	54	I	I	NNP
cord-006860-a3b8hyyr	4267	55	)	)	-RRB-
cord-006860-a3b8hyyr	4267	56	,	,	,
cord-006860-a3b8hyyr	4267	57	Hepatitis	Hepatitis	NNP
cord-006860-a3b8hyyr	4267	58	B	B	NNP
cord-006860-a3b8hyyr	4267	59	virus	virus	NN
cord-006860-a3b8hyyr	4267	60	(	(	-LRB-
cord-006860-a3b8hyyr	4267	61	HBV	HBV	NNP
cord-006860-a3b8hyyr	4267	62	)	)	-RRB-
cord-006860-a3b8hyyr	4267	63	and	and	CC
cord-006860-a3b8hyyr	4267	64	Hepatitis	Hepatitis	NNP
cord-006860-a3b8hyyr	4267	65	C	C	NNP
cord-006860-a3b8hyyr	4267	66	virus	virus	NN
cord-006860-a3b8hyyr	4267	67	(	(	-LRB-
cord-006860-a3b8hyyr	4267	68	HCV	HCV	NNP
cord-006860-a3b8hyyr	4267	69	)	)	-RRB-
cord-006860-a3b8hyyr	4267	70	in	in	IN
cord-006860-a3b8hyyr	4267	71	plasma	plasma	NN
cord-006860-a3b8hyyr	4267	72	and	and	CC
cord-006860-a3b8hyyr	4267	73	plasma	plasma	NN
cord-006860-a3b8hyyr	4267	74	products	product	NNS
cord-006860-a3b8hyyr	4267	75	.	.	.
cord-006860-a3b8hyyr	4268	1	The	the	DT
cord-006860-a3b8hyyr	4268	2	detection	detection	NN
cord-006860-a3b8hyyr	4268	3	of	of	IN
cord-006860-a3b8hyyr	4268	4	PCR	PCR	NNP
cord-006860-a3b8hyyr	4268	5	products	product	NNS
cord-006860-a3b8hyyr	4268	6	is	be	VBZ
cord-006860-a3b8hyyr	4268	7	carried	carry	VBN
cord-006860-a3b8hyyr	4268	8	out	out	RP
cord-006860-a3b8hyyr	4268	9	by	by	IN
cord-006860-a3b8hyyr	4268	10	laser	laser	NN
cord-006860-a3b8hyyr	4268	11	induced	induce	VBN
cord-006860-a3b8hyyr	4268	12	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	4268	13	,	,	,
cord-006860-a3b8hyyr	4268	14	the	the	DT
cord-006860-a3b8hyyr	4268	15	procedure	procedure	NN
cord-006860-a3b8hyyr	4268	16	is	be	VBZ
cord-006860-a3b8hyyr	4268	17	therefore	therefore	RB
cord-006860-a3b8hyyr	4268	18	termed	term	VBN
cord-006860-a3b8hyyr	4268	19	"	"	``
cord-006860-a3b8hyyr	4268	20	laser	laser	NN
cord-006860-a3b8hyyr	4268	21	induced	induce	VBN
cord-006860-a3b8hyyr	4268	22	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	4268	23	PCR	PCR	NNP
cord-006860-a3b8hyyr	4268	24	"	"	''
cord-006860-a3b8hyyr	4268	25	(	(	-LRB-
cord-006860-a3b8hyyr	4268	26	LIF	LIF	NNP
cord-006860-a3b8hyyr	4268	27	-	-	HYPH
cord-006860-a3b8hyyr	4268	28	PCR	PCR	NNP
cord-006860-a3b8hyyr	4268	29	)	)	-RRB-
cord-006860-a3b8hyyr	4268	30	.	.	.
cord-006860-a3b8hyyr	4269	1	The	the	DT
cord-006860-a3b8hyyr	4269	2	procedure	procedure	NN
cord-006860-a3b8hyyr	4269	3	allows	allow	VBZ
cord-006860-a3b8hyyr	4269	4	the	the	DT
cord-006860-a3b8hyyr	4269	5	precise	precise	JJ
cord-006860-a3b8hyyr	4269	6	quantitation	quantitation	NN
cord-006860-a3b8hyyr	4269	7	of	of	IN
cord-006860-a3b8hyyr	4269	8	genome	genome	NN
cord-006860-a3b8hyyr	4269	9	equivalents	equivalent	NNS
cord-006860-a3b8hyyr	4269	10	due	due	JJ
cord-006860-a3b8hyyr	4269	11	to	to	IN
cord-006860-a3b8hyyr	4269	12	the	the	DT
cord-006860-a3b8hyyr	4269	13	use	use	NN
cord-006860-a3b8hyyr	4269	14	of	of	IN
cord-006860-a3b8hyyr	4269	15	two	two	CD
cord-006860-a3b8hyyr	4269	16	calibrators	calibrator	NNS
cord-006860-a3b8hyyr	4269	17	that	that	WDT
cord-006860-a3b8hyyr	4269	18	are	be	VBP
cord-006860-a3b8hyyr	4269	19	co	co	VBN
cord-006860-a3b8hyyr	4269	20	-	-	VBN
cord-006860-a3b8hyyr	4269	21	amplified	amplify	VBN
cord-006860-a3b8hyyr	4269	22	by	by	IN
cord-006860-a3b8hyyr	4269	23	the	the	DT
cord-006860-a3b8hyyr	4269	24	same	same	JJ
cord-006860-a3b8hyyr	4269	25	set	set	NN
cord-006860-a3b8hyyr	4269	26	of	of	IN
cord-006860-a3b8hyyr	4269	27	primers	primer	NNS
cord-006860-a3b8hyyr	4269	28	as	as	IN
cord-006860-a3b8hyyr	4269	29	the	the	DT
cord-006860-a3b8hyyr	4269	30	target	target	NN
cord-006860-a3b8hyyr	4269	31	template	template	NN
cord-006860-a3b8hyyr	4269	32	in	in	IN
cord-006860-a3b8hyyr	4269	33	one	one	CD
cord-006860-a3b8hyyr	4269	34	and	and	CC
cord-006860-a3b8hyyr	4269	35	the	the	DT
cord-006860-a3b8hyyr	4269	36	same	same	JJ
cord-006860-a3b8hyyr	4269	37	test	test	NN
cord-006860-a3b8hyyr	4269	38	tube	tube	NN
cord-006860-a3b8hyyr	4269	39	.	.	.
cord-006860-a3b8hyyr	4270	1	A	a	DT
cord-006860-a3b8hyyr	4270	2	high	high	JJ
cord-006860-a3b8hyyr	4270	3	degree	degree	NN
cord-006860-a3b8hyyr	4270	4	of	of	IN
cord-006860-a3b8hyyr	4270	5	reliability	reliability	NN
cord-006860-a3b8hyyr	4270	6	is	be	VBZ
cord-006860-a3b8hyyr	4270	7	achieved	achieve	VBN
cord-006860-a3b8hyyr	4270	8	by	by	IN
cord-006860-a3b8hyyr	4270	9	co	co	NN
cord-006860-a3b8hyyr	4270	10	-	-	NN
cord-006860-a3b8hyyr	4270	11	precipitation	precipitation	NN
cord-006860-a3b8hyyr	4270	12	of	of	IN
cord-006860-a3b8hyyr	4270	13	the	the	DT
cord-006860-a3b8hyyr	4270	14	extract	extract	NN
cord-006860-a3b8hyyr	4270	15	,	,	,
cord-006860-a3b8hyyr	4270	16	co	co	NN
cord-006860-a3b8hyyr	4270	17	-	-	NN
cord-006860-a3b8hyyr	4270	18	amplification	amplification	NN
cord-006860-a3b8hyyr	4270	19	and	and	CC
cord-006860-a3b8hyyr	4270	20	co	co	NN
cord-006860-a3b8hyyr	4270	21	-	-	NN
cord-006860-a3b8hyyr	4270	22	determination	determination	NN
cord-006860-a3b8hyyr	4270	23	of	of	IN
cord-006860-a3b8hyyr	4270	24	the	the	DT
cord-006860-a3b8hyyr	4270	25	calibrators	calibrator	NNS
cord-006860-a3b8hyyr	4270	26	together	together	RB
cord-006860-a3b8hyyr	4270	27	with	with	IN
cord-006860-a3b8hyyr	4270	28	the	the	DT
cord-006860-a3b8hyyr	4270	29	genome	genome	NN
cord-006860-a3b8hyyr	4270	30	equivalents	equivalent	NNS
cord-006860-a3b8hyyr	4270	31	to	to	TO
cord-006860-a3b8hyyr	4270	32	be	be	VB
cord-006860-a3b8hyyr	4270	33	determined	determine	VBN
cord-006860-a3b8hyyr	4270	34	.	.	.
cord-006860-a3b8hyyr	4271	1	In	in	IN
cord-006860-a3b8hyyr	4271	2	this	this	DT
cord-006860-a3b8hyyr	4271	3	report	report	NN
cord-006860-a3b8hyyr	4271	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	4271	5	present	present	VBP
cord-006860-a3b8hyyr	4271	6	validation	validation	NN
cord-006860-a3b8hyyr	4271	7	data	datum	NNS
cord-006860-a3b8hyyr	4271	8	for	for	IN
cord-006860-a3b8hyyr	4271	9	the	the	DT
cord-006860-a3b8hyyr	4271	10	LIF	LIF	NNP
cord-006860-a3b8hyyr	4271	11	-	-	HYPH
cord-006860-a3b8hyyr	4271	12	PCR	PCR	NNP
cord-006860-a3b8hyyr	4271	13	and	and	CC
cord-006860-a3b8hyyr	4271	14	discuss	discuss	VB
cord-006860-a3b8hyyr	4271	15	them	-PRON-	PRP
cord-006860-a3b8hyyr	4271	16	in	in	IN
cord-006860-a3b8hyyr	4271	17	the	the	DT
cord-006860-a3b8hyyr	4271	18	light	light	NN
cord-006860-a3b8hyyr	4271	19	of	of	IN
cord-006860-a3b8hyyr	4271	20	the	the	DT
cord-006860-a3b8hyyr	4271	21	recently	recently	RB
cord-006860-a3b8hyyr	4271	22	published	publish	VBN
cord-006860-a3b8hyyr	4271	23	ICH	ICH	NNP
cord-006860-a3b8hyyr	4271	24	-	-	HYPH
cord-006860-a3b8hyyr	4271	25	Guidelines	Guidelines	NNP
cord-006860-a3b8hyyr	4271	26	on	on	IN
cord-006860-a3b8hyyr	4271	27	the	the	DT
cord-006860-a3b8hyyr	4271	28	validation	validation	NN
cord-006860-a3b8hyyr	4271	29	of	of	IN
cord-006860-a3b8hyyr	4271	30	analytical	analytical	JJ
cord-006860-a3b8hyyr	4271	31	procedures	procedure	NNS
cord-006860-a3b8hyyr	4271	32	.	.	.
cord-006860-a3b8hyyr	4271	33	 	 	_SP
cord-006860-a3b8hyyr	4272	1	Taking	take	VBG
cord-006860-a3b8hyyr	4272	2	into	into	IN
cord-006860-a3b8hyyr	4272	3	account	account	NN
cord-006860-a3b8hyyr	4273	1	the	the	DT
cord-006860-a3b8hyyr	4273	2	pecularitles	pecularitle	NNS
cord-006860-a3b8hyyr	4273	3	of	of	IN
cord-006860-a3b8hyyr	4273	4	the	the	DT
cord-006860-a3b8hyyr	4273	5	replacement	replacement	NN
cord-006860-a3b8hyyr	4273	6	therapy	therapy	NN
cord-006860-a3b8hyyr	4273	7	of	of	IN
cord-006860-a3b8hyyr	4273	8	haemcphiliacs	haemcphiliacs	NNP
cord-006860-a3b8hyyr	4273	9	in	in	IN
cord-006860-a3b8hyyr	4273	10	Romania	Romania	NNP
cord-006860-a3b8hyyr	4273	11	the	the	DT
cord-006860-a3b8hyyr	4273	12	study	study	NN
cord-006860-a3b8hyyr	4273	13	aimed	aim	VBN
cord-006860-a3b8hyyr	4273	14	at	at	IN
cord-006860-a3b8hyyr	4273	15	evaluating	evaluate	VBG
cord-006860-a3b8hyyr	4273	16	the	the	DT
cord-006860-a3b8hyyr	4273	17	dimension	dimension	NN
cord-006860-a3b8hyyr	4273	18	and	and	CC
cord-006860-a3b8hyyr	4273	19	profile	profile	NN
cord-006860-a3b8hyyr	4273	20	of	of	IN
cord-006860-a3b8hyyr	4273	21	blood	blood	NN
cord-006860-a3b8hyyr	4273	22	-	-	HYPH
cord-006860-a3b8hyyr	4273	23	born	bear	VBN
cord-006860-a3b8hyyr	4273	24	infections	infection	NNS
cord-006860-a3b8hyyr	4273	25	in	in	IN
cord-006860-a3b8hyyr	4273	26	these	these	DT
cord-006860-a3b8hyyr	4273	27	patients	patient	NNS
cord-006860-a3b8hyyr	4273	28	;	;	:
cord-006860-a3b8hyyr	4273	29	142	142	CD
cord-006860-a3b8hyyr	4273	30	hsemophlllacs	hsemophlllac	NNS
cord-006860-a3b8hyyr	4273	31	,	,	,
cord-006860-a3b8hyyr	4273	32	elasslfled	elasslfle	VBN
cord-006860-a3b8hyyr	4273	33	in	in	IN
cord-006860-a3b8hyyr	4273	34	3	3	CD
cord-006860-a3b8hyyr	4273	35	groups	group	NNS
cord-006860-a3b8hyyr	4273	36	:	:	:
cord-006860-a3b8hyyr	4273	37	A	a	DT
cord-006860-a3b8hyyr	4273	38	-	-	HYPH
cord-006860-a3b8hyyr	4273	39	ulth	ulth	NN
cord-006860-a3b8hyyr	4273	40	no	no	DT
cord-006860-a3b8hyyr	4273	41	exposure	exposure	NN
cord-006860-a3b8hyyr	4273	42	to	to	IN
cord-006860-a3b8hyyr	4273	43	blood	blood	NN
cord-006860-a3b8hyyr	4273	44	or	or	CC
cord-006860-a3b8hyyr	4273	45	bloodproducts	bloodproduct	NNS
cord-006860-a3b8hyyr	4273	46	,	,	,
cord-006860-a3b8hyyr	4273	47	B	b	NN
cord-006860-a3b8hyyr	4273	48	-	-	HYPH
cord-006860-a3b8hyyr	4273	49	treated	treat	VBN
cord-006860-a3b8hyyr	4273	50	~ith	~ith	NNP
cord-006860-a3b8hyyr	4273	51	factor	factor	NN
cord-006860-a3b8hyyr	4273	52	-	-	HYPH
cord-006860-a3b8hyyr	4273	53	concentrates	concentrate	NNS
cord-006860-a3b8hyyr	4273	54	and	and	CC
cord-006860-a3b8hyyr	4273	55	C	c	NN
cord-006860-a3b8hyyr	4273	56	-	-	HYPH
cord-006860-a3b8hyyr	4273	57	ulth	ulth	NN
cord-006860-a3b8hyyr	4273	58	plasma	plasma	NN
cord-006860-a3b8hyyr	4273	59	,	,	,
cord-006860-a3b8hyyr	4273	60	cryoprecipItate	cryoprecipItate	NNP
cord-006860-a3b8hyyr	4274	1	+	+	CC
cord-006860-a3b8hyyr	4274	2	factor	factor	NN
cord-006860-a3b8hyyr	4274	3	-	-	HYPH
cord-006860-a3b8hyyr	4274	4	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	4274	5	in	in	IN
cord-006860-a3b8hyyr	4274	6	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4274	7	therapy	therapy	NN
cord-006860-a3b8hyyr	4274	8	have	have	VBP
cord-006860-a3b8hyyr	4274	9	been	be	VBN
cord-006860-a3b8hyyr	4274	10	investigated	investigate	VBN
cord-006860-a3b8hyyr	4274	11	(	(	-LRB-
cord-006860-a3b8hyyr	4274	12	Elisa	Elisa	NNP
cord-006860-a3b8hyyr	4274	13	method	method	NN
cord-006860-a3b8hyyr	4274	14	)	)	-RRB-
cord-006860-a3b8hyyr	4274	15	for	for	IN
cord-006860-a3b8hyyr	4274	16	serological	serological	JJ
cord-006860-a3b8hyyr	4274	17	markers	marker	NNS
cord-006860-a3b8hyyr	4274	18	of	of	IN
cord-006860-a3b8hyyr	4274	19	Hepatitis	Hepatitis	NNP
cord-006860-a3b8hyyr	4274	20	A	A	NNP
cord-006860-a3b8hyyr	4274	21	,	,	,
cord-006860-a3b8hyyr	4274	22	B	b	NN
cord-006860-a3b8hyyr	4274	23	,	,	,
cord-006860-a3b8hyyr	4274	24	C	c	NN
cord-006860-a3b8hyyr	4274	25	end	end	NN
cord-006860-a3b8hyyr	4274	26	D	d	NN
cord-006860-a3b8hyyr	4274	27	,	,	,
cord-006860-a3b8hyyr	4274	28	Cvtomegalovirus	Cvtomegalovirus	NNP
cord-006860-a3b8hyyr	4274	29	(	(	-LRB-
cord-006860-a3b8hyyr	4274	30	CMV	CMV	NNP
cord-006860-a3b8hyyr	4274	31	)	)	-RRB-
cord-006860-a3b8hyyr	4274	32	and	and	CC
cord-006860-a3b8hyyr	4275	1	HIV	HIV	NNP
cord-006860-a3b8hyyr	4275	2	I	I	NNP
cord-006860-a3b8hyyr	4275	3	and	and	CC
cord-006860-a3b8hyyr	4275	4	HIU	HIU	NNP
cord-006860-a3b8hyyr	4275	5	9	9	CD
cord-006860-a3b8hyyr	4275	6	infection	infection	NN
cord-006860-a3b8hyyr	4275	7	.	.	.
cord-006860-a3b8hyyr	4276	1	The	the	DT
cord-006860-a3b8hyyr	4276	2	infections	infection	NNS
cord-006860-a3b8hyyr	4276	3	profile	profile	NN
cord-006860-a3b8hyyr	4276	4	of	of	IN
cord-006860-a3b8hyyr	4276	5	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4276	6	haemophiliacs	haemophiliac	NNS
cord-006860-a3b8hyyr	4276	7	~	~	NFP
cord-006860-a3b8hyyr	4276	8	hes	hes	UH
cord-006860-a3b8hyyr	4276	9	some	some	DT
cord-006860-a3b8hyyr	4276	10	peculsrities	peculsritie	NNS
cord-006860-a3b8hyyr	4276	11	.	.	.
cord-006860-a3b8hyyr	4277	1	The	the	DT
cord-006860-a3b8hyyr	4277	2	hepatitis	hepatitis	NN
cord-006860-a3b8hyyr	4277	3	infection	infection	NN
cord-006860-a3b8hyyr	4277	4	is	be	VBZ
cord-006860-a3b8hyyr	4277	5	the	the	DT
cord-006860-a3b8hyyr	4277	6	most	most	RBS
cord-006860-a3b8hyyr	4277	7	extended	extended	JJ
cord-006860-a3b8hyyr	4277	8	,	,	,
cord-006860-a3b8hyyr	4277	9	lnvolving	lnvolve	VBG
cord-006860-a3b8hyyr	4277	10	more	more	JJR
cord-006860-a3b8hyyr	4277	11	than	than	IN
cord-006860-a3b8hyyr	4277	12	75	75	CD
cord-006860-a3b8hyyr	4277	13	%	%	NN
cord-006860-a3b8hyyr	4277	14	of	of	IN
cord-006860-a3b8hyyr	4277	15	the	the	DT
cord-006860-a3b8hyyr	4277	16	patients	patient	NNS
cord-006860-a3b8hyyr	4277	17	.	.	.
cord-006860-a3b8hyyr	4278	1	The	the	DT
cord-006860-a3b8hyyr	4278	2	frequency	frequency	NN
cord-006860-a3b8hyyr	4278	3	is	be	VBZ
cord-006860-a3b8hyyr	4278	4	for	for	IN
cord-006860-a3b8hyyr	4278	5	Hepatitis	Hepatitis	NNP
cord-006860-a3b8hyyr	4278	6	-bZ	-bZ	NNP
cord-006860-a3b8hyyr	4278	7	,	,	,
cord-006860-a3b8hyyr	4278	8	Z~	Z~	NNP
cord-006860-a3b8hyyr	4278	9	,	,	,
cord-006860-a3b8hyyr	4278	10	U	U	NNP
cord-006860-a3b8hyyr	4278	11	-"/~,~	-"/~,~	''
cord-006860-a3b8hyyr	4278	12	,	,	,
cord-006860-a3b8hyyr	4279	1	G	g	NN
cord-006860-a3b8hyyr	4279	2	-bb,7	-bb,7	NN
cord-006860-a3b8hyyr	4279	3	%	%	NN
cord-006860-a3b8hyyr	4279	4	end	end	NN
cord-006860-a3b8hyyr	4279	5	O	o	UH
cord-006860-a3b8hyyr	4279	6	-24	-24	,
cord-006860-a3b8hyyr	4279	7	%	%	NN
cord-006860-a3b8hyyr	4279	8	:	:	:
cord-006860-a3b8hyyr	4279	9	the	the	DT
cord-006860-a3b8hyyr	4279	10	multiple	multiple	JJ
cord-006860-a3b8hyyr	4279	11	infection	infection	NN
cord-006860-a3b8hyyr	4279	12	was	be	VBD
cord-006860-a3b8hyyr	4279	13	diagnosed	diagnose	VBN
cord-006860-a3b8hyyr	4279	14	in	in	IN
cord-006860-a3b8hyyr	4279	15	more	more	JJR
cord-006860-a3b8hyyr	4279	16	than	than	IN
cord-006860-a3b8hyyr	4279	17	50	50	CD
cord-006860-a3b8hyyr	4279	18	%	%	NN
cord-006860-a3b8hyyr	4279	19	of	of	IN
cord-006860-a3b8hyyr	4279	20	cases	case	NNS
cord-006860-a3b8hyyr	4279	21	.	.	.
cord-006860-a3b8hyyr	4280	1	The	the	DT
cord-006860-a3b8hyyr	4280	2	prevalence	prevalence	NN
cord-006860-a3b8hyyr	4280	3	uas	uas	NNP
cord-006860-a3b8hyyr	4280	4	significantly	significantly	RB
cord-006860-a3b8hyyr	4280	5	hlgher	hlgher	VBP
cord-006860-a3b8hyyr	4280	6	in	in	IN
cord-006860-a3b8hyyr	4280	7	the	the	DT
cord-006860-a3b8hyyr	4280	8	group	group	NN
cord-006860-a3b8hyyr	4281	1	C.	C.	NNP
cord-006860-a3b8hyyr	4281	2	We	-PRON-	PRP
cord-006860-a3b8hyyr	4281	3	studied	study	VBD
cord-006860-a3b8hyyr	4281	4	blood	blood	NN
cord-006860-a3b8hyyr	4281	5	count	count	NN
cord-006860-a3b8hyyr	4281	6	and	and	CC
cord-006860-a3b8hyyr	4281	7	relevant	relevant	JJ
cord-006860-a3b8hyyr	4281	8	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4281	9	system	system	NN
cord-006860-a3b8hyyr	4281	10	parameters	parameter	NNS
cord-006860-a3b8hyyr	4281	11	of	of	IN
cord-006860-a3b8hyyr	4281	12	autologous	autologous	JJ
cord-006860-a3b8hyyr	4281	13	blood	blood	NN
cord-006860-a3b8hyyr	4281	14	donors	donor	NNS
cord-006860-a3b8hyyr	4281	15	.	.	.
cord-006860-a3b8hyyr	4282	1	Indications	indication	NNS
cord-006860-a3b8hyyr	4282	2	for	for	IN
cord-006860-a3b8hyyr	4282	3	autologous	autologous	JJ
cord-006860-a3b8hyyr	4282	4	blood	blood	NN
cord-006860-a3b8hyyr	4282	5	donation	donation	NN
cord-006860-a3b8hyyr	4282	6	were	be	VBD
cord-006860-a3b8hyyr	4282	7	divided	divide	VBN
cord-006860-a3b8hyyr	4282	8	in	in	IN
cord-006860-a3b8hyyr	4282	9	4	4	CD
cord-006860-a3b8hyyr	4282	10	categories	category	NNS
cord-006860-a3b8hyyr	4282	11	:	:	:
cord-006860-a3b8hyyr	4282	12	a	a	DT
cord-006860-a3b8hyyr	4282	13	group	group	NN
cord-006860-a3b8hyyr	4282	14	of	of	IN
cord-006860-a3b8hyyr	4282	15	diverse	diverse	JJ
cord-006860-a3b8hyyr	4282	16	(	(	-LRB-
cord-006860-a3b8hyyr	4282	17	A	A	NNP
cord-006860-a3b8hyyr	4282	18	,	,	,
cord-006860-a3b8hyyr	4282	19	n=13	n=13	NNP
cord-006860-a3b8hyyr	4282	20	)	)	-RRB-
cord-006860-a3b8hyyr	4282	21	,	,	,
cord-006860-a3b8hyyr	4282	22	reduction	reduction	NN
cord-006860-a3b8hyyr	4282	23	mammoplasty	mammoplasty	NN
cord-006860-a3b8hyyr	4282	24	(	(	-LRB-
cord-006860-a3b8hyyr	4282	25	B	B	NNP
cord-006860-a3b8hyyr	4282	26	,	,	,
cord-006860-a3b8hyyr	4282	27	n:5	n:5	NNP
cord-006860-a3b8hyyr	4282	28	)	)	-RRB-
cord-006860-a3b8hyyr	4282	29	,	,	,
cord-006860-a3b8hyyr	4282	30	prostatectomy	prostatectomy	NN
cord-006860-a3b8hyyr	4282	31	(	(	-LRB-
cord-006860-a3b8hyyr	4282	32	C	C	NNP
cord-006860-a3b8hyyr	4282	33	,	,	,
cord-006860-a3b8hyyr	4282	34	n	n	NN
cord-006860-a3b8hyyr	4282	35	=	=	SYM
cord-006860-a3b8hyyr	4282	36	IO	IO	NNP
cord-006860-a3b8hyyr	4282	37	)	)	-RRB-
cord-006860-a3b8hyyr	4282	38	and	and	CC
cord-006860-a3b8hyyr	4282	39	total	total	JJ
cord-006860-a3b8hyyr	4282	40	hip	hip	NN
cord-006860-a3b8hyyr	4282	41	replacement	replacement	NN
cord-006860-a3b8hyyr	4282	42	(	(	-LRB-
cord-006860-a3b8hyyr	4282	43	D	D	NNP
cord-006860-a3b8hyyr	4282	44	,	,	,
cord-006860-a3b8hyyr	4282	45	n=74	n=74	NNP
cord-006860-a3b8hyyr	4282	46	)	)	-RRB-
cord-006860-a3b8hyyr	4282	47	.	.	.
cord-006860-a3b8hyyr	4283	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4283	2	performed	perform	VBD
cord-006860-a3b8hyyr	4283	3	bleod	bleod	NN
cord-006860-a3b8hyyr	4283	4	count	count	NN
cord-006860-a3b8hyyr	4283	5	(	(	-LRB-
cord-006860-a3b8hyyr	4283	6	BC	BC	NNP
cord-006860-a3b8hyyr	4283	7	)	)	-RRB-
cord-006860-a3b8hyyr	4283	8	,	,	,
cord-006860-a3b8hyyr	4283	9	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	4283	10	time	time	NN
cord-006860-a3b8hyyr	4283	11	(	(	-LRB-
cord-006860-a3b8hyyr	4283	12	TT	TT	NNP
cord-006860-a3b8hyyr	4283	13	)	)	-RRB-
cord-006860-a3b8hyyr	4283	14	,	,	,
cord-006860-a3b8hyyr	4283	15	partial	partial	JJ
cord-006860-a3b8hyyr	4283	16	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	4283	17	time	time	NN
cord-006860-a3b8hyyr	4283	18	(	(	-LRB-
cord-006860-a3b8hyyr	4283	19	aPTT	aptt	NN
cord-006860-a3b8hyyr	4283	20	)	)	-RRB-
cord-006860-a3b8hyyr	4283	21	,	,	,
cord-006860-a3b8hyyr	4283	22	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4283	23	(	(	-LRB-
cord-006860-a3b8hyyr	4283	24	Fib	Fib	NNP
cord-006860-a3b8hyyr	4283	25	)	)	-RRB-
cord-006860-a3b8hyyr	4283	26	,	,	,
cord-006860-a3b8hyyr	4283	27	F	F	NNP
cord-006860-a3b8hyyr	4283	28	VHI	VHI	NNP
cord-006860-a3b8hyyr	4283	29	Act	Act	NNP
cord-006860-a3b8hyyr	4283	30	,	,	,
cord-006860-a3b8hyyr	4283	31	vWF	vWF	NNP
cord-006860-a3b8hyyr	4283	32	RCo	RCo	NNP
cord-006860-a3b8hyyr	4283	33	,	,	,
cord-006860-a3b8hyyr	4283	34	vWF	vWF	NNP
cord-006860-a3b8hyyr	4283	35	Ag	Ag	NNP
cord-006860-a3b8hyyr	4283	36	,	,	,
cord-006860-a3b8hyyr	4283	37	F	F	NNP
cord-006860-a3b8hyyr	4283	38	XIII	XIII	NNP
cord-006860-a3b8hyyr	4283	39	,	,	,
cord-006860-a3b8hyyr	4283	40	AT	AT	NNP
cord-006860-a3b8hyyr	4283	41	III	III	NNP
cord-006860-a3b8hyyr	4283	42	,	,	,
cord-006860-a3b8hyyr	4283	43	D	d	NN
cord-006860-a3b8hyyr	4283	44	-	-	HYPH
cord-006860-a3b8hyyr	4283	45	dimer	dimer	NN
cord-006860-a3b8hyyr	4283	46	-	-	HYPH
cord-006860-a3b8hyyr	4283	47	fragments	fragment	NNS
cord-006860-a3b8hyyr	4283	48	(	(	-LRB-
cord-006860-a3b8hyyr	4283	49	DD	DD	NNP
cord-006860-a3b8hyyr	4283	50	)	)	-RRB-
cord-006860-a3b8hyyr	4283	51	and	and	CC
cord-006860-a3b8hyyr	4283	52	fibrinmonomers	fibrinmonomers	NNP
cord-006860-a3b8hyyr	4283	53	(	(	-LRB-
cord-006860-a3b8hyyr	4283	54	FM	FM	NNP
cord-006860-a3b8hyyr	4283	55	)	)	-RRB-
cord-006860-a3b8hyyr	4283	56	.	.	.
cord-006860-a3b8hyyr	4284	1	All	all	DT
cord-006860-a3b8hyyr	4284	2	parameters	parameter	NNS
cord-006860-a3b8hyyr	4284	3	were	be	VBD
cord-006860-a3b8hyyr	4284	4	analyzed	analyze	VBN
cord-006860-a3b8hyyr	4284	5	as	as	IN
cord-006860-a3b8hyyr	4284	6	initial	initial	JJ
cord-006860-a3b8hyyr	4284	7	value	value	NN
cord-006860-a3b8hyyr	4284	8	,	,	,
cord-006860-a3b8hyyr	4284	9	BC	BC	NNP
cord-006860-a3b8hyyr	4284	10	,	,	,
cord-006860-a3b8hyyr	4284	11	TT	TT	NNP
cord-006860-a3b8hyyr	4284	12	,	,	,
cord-006860-a3b8hyyr	4284	13	aPTT	aptt	NN
cord-006860-a3b8hyyr	4284	14	,	,	,
cord-006860-a3b8hyyr	4284	15	Fib	Fib	NNP
cord-006860-a3b8hyyr	4284	16	,	,	,
cord-006860-a3b8hyyr	4284	17	F	F	NNP
cord-006860-a3b8hyyr	4284	18	XIII	XIII	NNP
cord-006860-a3b8hyyr	4284	19	and	and	CC
cord-006860-a3b8hyyr	4284	20	AT	AT	NNP
cord-006860-a3b8hyyr	4284	21	III	III	NNP
cord-006860-a3b8hyyr	4284	22	were	be	VBD
cord-006860-a3b8hyyr	4284	23	measured	measure	VBN
cord-006860-a3b8hyyr	4284	24	additionally	additionally	RB
cord-006860-a3b8hyyr	4284	25	at	at	IN
cord-006860-a3b8hyyr	4284	26	each	each	DT
cord-006860-a3b8hyyr	4284	27	donation	donation	NN
cord-006860-a3b8hyyr	4284	28	.	.	.
cord-006860-a3b8hyyr	4285	1	The	the	DT
cord-006860-a3b8hyyr	4285	2	percentage	percentage	NN
cord-006860-a3b8hyyr	4285	3	of	of	IN
cord-006860-a3b8hyyr	4285	4	initial	initial	JJ
cord-006860-a3b8hyyr	4285	5	pathologic	pathologic	JJ
cord-006860-a3b8hyyr	4285	6	data	datum	NNS
cord-006860-a3b8hyyr	4285	7	was	be	VBD
cord-006860-a3b8hyyr	4285	8	(	(	-LRB-
cord-006860-a3b8hyyr	4285	9	1	1	CD
cord-006860-a3b8hyyr	4285	10	)	)	-RRB-
cord-006860-a3b8hyyr	4285	11	were	be	VBD
cord-006860-a3b8hyyr	4285	12	included	include	VBN
cord-006860-a3b8hyyr	4285	13	in	in	IN
cord-006860-a3b8hyyr	4285	14	the	the	DT
cord-006860-a3b8hyyr	4285	15	study	study	NN
cord-006860-a3b8hyyr	4285	16	.	.	.
cord-006860-a3b8hyyr	4286	1	The	the	DT
cord-006860-a3b8hyyr	4286	2	inclusion	inclusion	NN
cord-006860-a3b8hyyr	4286	3	criterittm	criterittm	NN
cord-006860-a3b8hyyr	4286	4	was	be	VBD
cord-006860-a3b8hyyr	4286	5	:	:	:
cord-006860-a3b8hyyr	4286	6	an	an	DT
cord-006860-a3b8hyyr	4286	7	endegen(y.~	endegen(y.~	NNP
cord-006860-a3b8hyyr	4286	8	red	red	JJ
cord-006860-a3b8hyyr	4286	9	cell	cell	NN
cord-006860-a3b8hyyr	4286	10	reserve	reserve	NN
cord-006860-a3b8hyyr	4286	11	(	(	-LRB-
cord-006860-a3b8hyyr	4286	12	ERCR	ERCR	NNP
cord-006860-a3b8hyyr	4286	13	)	)	-RRB-
cord-006860-a3b8hyyr	4286	14	of	of	IN
cord-006860-a3b8hyyr	4286	15	less	less	JJR
cord-006860-a3b8hyyr	4286	16	than	than	IN
cord-006860-a3b8hyyr	4286	17	400	400	CD
cord-006860-a3b8hyyr	4286	18	ml	ml	NNS
cord-006860-a3b8hyyr	4286	19	in	in	IN
cord-006860-a3b8hyyr	4286	20	men	man	NNS
cord-006860-a3b8hyyr	4286	21	and	and	CC
cord-006860-a3b8hyyr	4286	22	less	less	JJR
cord-006860-a3b8hyyr	4286	23	than	than	IN
cord-006860-a3b8hyyr	4286	24	540	540	CD
cord-006860-a3b8hyyr	4286	25	ml	ml	NNS
cord-006860-a3b8hyyr	4286	26	in	in	IN
cord-006860-a3b8hyyr	4286	27	women	woman	NNS
cord-006860-a3b8hyyr	4286	28	.	.	.
cord-006860-a3b8hyyr	4287	1	ERCR	ERCR	NNP
cord-006860-a3b8hyyr	4287	2	is	be	VBZ
cord-006860-a3b8hyyr	4287	3	the	the	DT
cord-006860-a3b8hyyr	4287	4	volume	volume	NN
cord-006860-a3b8hyyr	4287	5	of	of	IN
cord-006860-a3b8hyyr	4287	6	blood	blood	NN
cord-006860-a3b8hyyr	4287	7	that	that	WDT
cord-006860-a3b8hyyr	4287	8	can	can	MD
cord-006860-a3b8hyyr	4287	9	be	be	VB
cord-006860-a3b8hyyr	4287	10	withdrawn	withdraw	VBN
cord-006860-a3b8hyyr	4287	11	up	up	RP
cord-006860-a3b8hyyr	4287	12	to	to	IN
cord-006860-a3b8hyyr	4287	13	tim	tim	NNP
cord-006860-a3b8hyyr	4287	14	hematocrit	hematocrit	NN
cord-006860-a3b8hyyr	4287	15	of	of	IN
cord-006860-a3b8hyyr	4287	16	0.34	0.34	CD
cord-006860-a3b8hyyr	4287	17	.	.	.
cord-006860-a3b8hyyr	4288	1	The	the	DT
cord-006860-a3b8hyyr	4288	2	selected	select	VBN
cord-006860-a3b8hyyr	4288	3	dosages	dosage	NNS
cord-006860-a3b8hyyr	4288	4	of	of	IN
cord-006860-a3b8hyyr	4288	5	rhEPO	rhEPO	NNP
cord-006860-a3b8hyyr	4288	6	(	(	-LRB-
cord-006860-a3b8hyyr	4288	7	200	200	CD
cord-006860-a3b8hyyr	4288	8	,	,	,
cord-006860-a3b8hyyr	4288	9	400	400	CD
cord-006860-a3b8hyyr	4288	10	and	and	CC
cord-006860-a3b8hyyr	4288	11	800	800	CD
cord-006860-a3b8hyyr	4288	12	IU	IU	NNP
cord-006860-a3b8hyyr	4288	13	/	/	SYM
cord-006860-a3b8hyyr	4288	14	kg	kg	NN
cord-006860-a3b8hyyr	4288	15	body	body	NN
cord-006860-a3b8hyyr	4288	16	weight	weight	NN
cord-006860-a3b8hyyr	4288	17	biweekly	biweekly	RB
cord-006860-a3b8hyyr	4288	18	over	over	IN
cord-006860-a3b8hyyr	4288	19	4	4	CD
cord-006860-a3b8hyyr	4288	20	weeks	week	NNS
cord-006860-a3b8hyyr	4288	21	)	)	-RRB-
cord-006860-a3b8hyyr	4288	22	were	be	VBD
cord-006860-a3b8hyyr	4288	23	based	base	VBN
cord-006860-a3b8hyyr	4288	24	on	on	IN
cord-006860-a3b8hyyr	4288	25	the	the	DT
cord-006860-a3b8hyyr	4288	26	calculated	calculate	VBN
cord-006860-a3b8hyyr	4288	27	blood	blood	NN
cord-006860-a3b8hyyr	4288	28	volume	volume	NN
cord-006860-a3b8hyyr	4288	29	and	and	CC
cord-006860-a3b8hyyr	4288	30	the	the	DT
cord-006860-a3b8hyyr	4288	31	ERCR	ERCR	NNP
cord-006860-a3b8hyyr	4288	32	.	.	.
cord-006860-a3b8hyyr	4289	1	A	a	DT
cord-006860-a3b8hyyr	4289	2	unit	unit	NN
cord-006860-a3b8hyyr	4289	3	of	of	IN
cord-006860-a3b8hyyr	4289	4	whole	whole	JJ
cord-006860-a3b8hyyr	4289	5	blood	blood	NN
cord-006860-a3b8hyyr	4289	6	,	,	,
cord-006860-a3b8hyyr	4289	7	separated	separate	VBD
cord-006860-a3b8hyyr	4289	8	into	into	IN
cord-006860-a3b8hyyr	4289	9	an	an	DT
cord-006860-a3b8hyyr	4289	10	autologens	autologens	JJ
cord-006860-a3b8hyyr	4289	11	red	red	JJ
cord-006860-a3b8hyyr	4289	12	cell	cell	NN
cord-006860-a3b8hyyr	4289	13	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4289	14	and	and	CC
cord-006860-a3b8hyyr	4289	15	one	one	CD
cord-006860-a3b8hyyr	4289	16	unit	unit	NN
cord-006860-a3b8hyyr	4289	17	of	of	IN
cord-006860-a3b8hyyr	4289	18	fresh	fresh	JJ
cord-006860-a3b8hyyr	4289	19	frozen	frozen	JJ
cord-006860-a3b8hyyr	4289	20	plasma	plasma	NN
cord-006860-a3b8hyyr	4289	21	,	,	,
cord-006860-a3b8hyyr	4289	22	was	be	VBD
cord-006860-a3b8hyyr	4289	23	collected	collect	VBN
cord-006860-a3b8hyyr	4289	24	when	when	WRB
cord-006860-a3b8hyyr	4289	25	]	]	-RRB-
cord-006860-a3b8hyyr	4289	26	mnoglobin	mnoglobin	NNP
cord-006860-a3b8hyyr	4289	27	concentration	concentration	NN
cord-006860-a3b8hyyr	4289	28	was	be	VBD
cord-006860-a3b8hyyr	4289	29	at	at	RB
cord-006860-a3b8hyyr	4289	30	least	least	JJS
cord-006860-a3b8hyyr	4289	31	11.5g/100	11.5g/100	CD
cord-006860-a3b8hyyr	4289	32	ml	ml	NN
cord-006860-a3b8hyyr	4289	33	(	(	-LRB-
cord-006860-a3b8hyyr	4289	34	or	or	CC
cord-006860-a3b8hyyr	4289	35	hematocrit	hematocrit	NN
cord-006860-a3b8hyyr	4289	36	was	be	VBD
cord-006860-a3b8hyyr	4289	37	at	at	IN
cord-006860-a3b8hyyr	4289	38	least	least	JJS
cord-006860-a3b8hyyr	4289	39	0.34	0.34	CD
cord-006860-a3b8hyyr	4289	40	)	)	-RRB-
cord-006860-a3b8hyyr	4289	41	up	up	IN
cord-006860-a3b8hyyr	4289	42	to	to	IN
cord-006860-a3b8hyyr	4289	43	an	an	DT
cord-006860-a3b8hyyr	4289	44	autologons	autologon	NNS
cord-006860-a3b8hyyr	4289	45	predeposit	predeposit	NN
cord-006860-a3b8hyyr	4289	46	of	of	IN
cord-006860-a3b8hyyr	4289	47	800	800	CD
cord-006860-a3b8hyyr	4289	48	ml	ml	NN
cord-006860-a3b8hyyr	4289	49	red	red	JJ
cord-006860-a3b8hyyr	4289	50	cell	cell	NN
cord-006860-a3b8hyyr	4289	51	volume	volume	NN
cord-006860-a3b8hyyr	4289	52	(	(	-LRB-
cord-006860-a3b8hyyr	4289	53	RCV	RCV	NNP
cord-006860-a3b8hyyr	4289	54	)	)	-RRB-
cord-006860-a3b8hyyr	4289	55	.	.	.
cord-006860-a3b8hyyr	4290	1	Additionaly	additionaly	RB
cord-006860-a3b8hyyr	4290	2	,	,	,
cord-006860-a3b8hyyr	4290	3	platelet	platelet	NN
cord-006860-a3b8hyyr	4290	4	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4290	5	and	and	CC
cord-006860-a3b8hyyr	4290	6	serum	serum	NN
cord-006860-a3b8hyyr	4290	7	ferritin	ferritin	NN
cord-006860-a3b8hyyr	4290	8	levels	level	NNS
cord-006860-a3b8hyyr	4290	9	were	be	VBD
cord-006860-a3b8hyyr	4290	10	measured~	measured~	NN
cord-006860-a3b8hyyr	4290	11	Results	result	NNS
cord-006860-a3b8hyyr	4290	12	:	:	:
cord-006860-a3b8hyyr	4290	13	At	at	IN
cord-006860-a3b8hyyr	4290	14	the	the	DT
cord-006860-a3b8hyyr	4290	15	initial	initial	JJ
cord-006860-a3b8hyyr	4290	16	clinical	clinical	JJ
cord-006860-a3b8hyyr	4290	17	examination	examination	NN
cord-006860-a3b8hyyr	4290	18	the	the	DT
cord-006860-a3b8hyyr	4290	19	ERCR	ERCR	NNP
cord-006860-a3b8hyyr	4290	20	was	be	VBD
cord-006860-a3b8hyyr	4290	21	333	333	CD
cord-006860-a3b8hyyr	4290	22	ml	ml	NNS
cord-006860-a3b8hyyr	4290	23	in	in	IN
cord-006860-a3b8hyyr	4290	24	women	woman	NNS
cord-006860-a3b8hyyr	4290	25	and	and	CC
cord-006860-a3b8hyyr	4290	26	307	307	CD
cord-006860-a3b8hyyr	4290	27	in	in	IN
cord-006860-a3b8hyyr	4290	28	men	man	NNS
cord-006860-a3b8hyyr	4290	29	.	.	.
cord-006860-a3b8hyyr	4291	1	This	this	DT
cord-006860-a3b8hyyr	4291	2	resulted	result	VBD
cord-006860-a3b8hyyr	4291	3	in	in	IN
cord-006860-a3b8hyyr	4291	4	a	a	DT
cord-006860-a3b8hyyr	4291	5	weekly	weekly	JJ
cord-006860-a3b8hyyr	4291	6	dosage	dosage	NN
cord-006860-a3b8hyyr	4291	7	of	of	IN
cord-006860-a3b8hyyr	4291	8	2x32.000	2x32.000	CD
cord-006860-a3b8hyyr	4291	9	IU	IU	NNP
cord-006860-a3b8hyyr	4291	10	rlaEPO	rlaEPO	VBD
cord-006860-a3b8hyyr	4291	11	in	in	IN
cord-006860-a3b8hyyr	4291	12	women	woman	NNS
cord-006860-a3b8hyyr	4291	13	and	and	CC
cord-006860-a3b8hyyr	4292	1	2x25.000	2x25.000	CD
cord-006860-a3b8hyyr	4292	2	IU	IU	NNP
cord-006860-a3b8hyyr	4292	3	rhEPO	rhepo	RB
cord-006860-a3b8hyyr	4292	4	in	in	IN
cord-006860-a3b8hyyr	4292	5	men	man	NNS
cord-006860-a3b8hyyr	4292	6	.	.	.
cord-006860-a3b8hyyr	4293	1	7	7	CD
cord-006860-a3b8hyyr	4293	2	patients	patient	NNS
cord-006860-a3b8hyyr	4293	3	donated	donate	VBN
cord-006860-a3b8hyyr	4293	4	5	5	CD
cord-006860-a3b8hyyr	4293	5	red	red	JJ
cord-006860-a3b8hyyr	4293	6	cell	cell	NN
cord-006860-a3b8hyyr	4293	7	each	each	DT
cord-006860-a3b8hyyr	4293	8	(	(	-LRB-
cord-006860-a3b8hyyr	4293	9	858	858	CD
cord-006860-a3b8hyyr	4293	10	ml	ml	NN
cord-006860-a3b8hyyr	4293	11	RCV	RCV	NNP
cord-006860-a3b8hyyr	4293	12	on	on	IN
cord-006860-a3b8hyyr	4293	13	an	an	DT
cord-006860-a3b8hyyr	4293	14	average	average	NN
cord-006860-a3b8hyyr	4293	15	)	)	-RRB-
cord-006860-a3b8hyyr	4293	16	within	within	IN
cord-006860-a3b8hyyr	4293	17	19.1	19.1	CD
cord-006860-a3b8hyyr	4293	18	days	day	NNS
cord-006860-a3b8hyyr	4293	19	.	.	.
cord-006860-a3b8hyyr	4294	1	The	the	DT
cord-006860-a3b8hyyr	4294	2	targeted	target	VBN
cord-006860-a3b8hyyr	4294	3	RCV	RCV	NNP
cord-006860-a3b8hyyr	4294	4	could	could	MD
cord-006860-a3b8hyyr	4294	5	not	not	RB
cord-006860-a3b8hyyr	4294	6	be	be	VB
cord-006860-a3b8hyyr	4294	7	reached	reach	VBN
cord-006860-a3b8hyyr	4294	8	in	in	IN
cord-006860-a3b8hyyr	4294	9	3	3	CD
cord-006860-a3b8hyyr	4294	10	patients	patient	NNS
cord-006860-a3b8hyyr	4294	11	because	because	IN
cord-006860-a3b8hyyr	4294	12	the	the	DT
cord-006860-a3b8hyyr	4294	13	operation	operation	NN
cord-006860-a3b8hyyr	4294	14	was	be	VBD
cord-006860-a3b8hyyr	4294	15	reschednled	reschednle	VBN
cord-006860-a3b8hyyr	4294	16	.	.	.
cord-006860-a3b8hyyr	4295	1	The	the	DT
cord-006860-a3b8hyyr	4295	2	collection	collection	NN
cord-006860-a3b8hyyr	4295	3	from	from	IN
cord-006860-a3b8hyyr	4295	4	one	one	CD
cord-006860-a3b8hyyr	4295	5	patient	patient	NN
cord-006860-a3b8hyyr	4295	6	had	have	VBD
cord-006860-a3b8hyyr	4295	7	to	to	TO
cord-006860-a3b8hyyr	4295	8	be	be	VB
cord-006860-a3b8hyyr	4295	9	aborted	abort	VBN
cord-006860-a3b8hyyr	4295	10	because	because	IN
cord-006860-a3b8hyyr	4295	11	of	of	IN
cord-006860-a3b8hyyr	4295	12	angina	angina	NN
cord-006860-a3b8hyyr	4295	13	pcetoris	pcetoris	NNP
cord-006860-a3b8hyyr	4295	14	complains	complain	VBZ
cord-006860-a3b8hyyr	4295	15	.	.	.
cord-006860-a3b8hyyr	4296	1	Tic	Tic	NNP
cord-006860-a3b8hyyr	4296	2	following	follow	VBG
cord-006860-a3b8hyyr	4296	3	side	side	NN
cord-006860-a3b8hyyr	4296	4	-	-	HYPH
cord-006860-a3b8hyyr	4296	5	cffczts	cffczts	NN
cord-006860-a3b8hyyr	4296	6	occurred	occur	VBD
cord-006860-a3b8hyyr	4296	7	:	:	:
cord-006860-a3b8hyyr	4296	8	episodic	episodic	NNP
cord-006860-a3b8hyyr	4296	9	hypcrteJlsion	hypcrtejlsion	NN
cord-006860-a3b8hyyr	4296	10	(	(	-LRB-
cord-006860-a3b8hyyr	4296	11	2	2	CD
cord-006860-a3b8hyyr	4296	12	tim~	tim~	CD
cord-006860-a3b8hyyr	4296	13	)	)	-RRB-
cord-006860-a3b8hyyr	4296	14	,	,	,
cord-006860-a3b8hyyr	4296	15	chest	chest	NN
cord-006860-a3b8hyyr	4296	16	pain	pain	NN
cord-006860-a3b8hyyr	4296	17	(	(	-LRB-
cord-006860-a3b8hyyr	4296	18	5	5	CD
cord-006860-a3b8hyyr	4296	19	)	)	-RRB-
cord-006860-a3b8hyyr	4296	20	,	,	,
cord-006860-a3b8hyyr	4296	21	fafigne	fafigne	NNP
cord-006860-a3b8hyyr	4296	22	(	(	-LRB-
cord-006860-a3b8hyyr	4296	23	8)	8)	NNP
cord-006860-a3b8hyyr	4296	24	,	,	,
cord-006860-a3b8hyyr	4296	25	inflnenza	inflnenza	NNP
cord-006860-a3b8hyyr	4296	26	-	-	HYPH
cord-006860-a3b8hyyr	4296	27	lihe	lihe	NNP
cord-006860-a3b8hyyr	4296	28	syndrome	syndrome	NN
cord-006860-a3b8hyyr	4296	29	(	(	-LRB-
cord-006860-a3b8hyyr	4296	30	3	3	CD
cord-006860-a3b8hyyr	4296	31	)	)	-RRB-
cord-006860-a3b8hyyr	4296	32	.	.	.
cord-006860-a3b8hyyr	4297	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	4297	2	count	count	NN
cord-006860-a3b8hyyr	4297	3	increased	increase	VBD
cord-006860-a3b8hyyr	4297	4	from	from	IN
cord-006860-a3b8hyyr	4297	5	initially	initially	RB
cord-006860-a3b8hyyr	4297	6	203	203	CD
cord-006860-a3b8hyyr	4297	7	4	4	CD
cord-006860-a3b8hyyr	4297	8	-	-	SYM
cord-006860-a3b8hyyr	4297	9	68	68	CD
cord-006860-a3b8hyyr	4298	1	x	x	SYM
cord-006860-a3b8hyyr	4298	2	10'//d	10'//d	CD
cord-006860-a3b8hyyr	4298	3	(	(	-LRB-
cord-006860-a3b8hyyr	4298	4	I00	I00	NNP
cord-006860-a3b8hyyr	4298	5	%	%	NN
cord-006860-a3b8hyyr	4298	6	)	)	-RRB-
cord-006860-a3b8hyyr	4299	1	during	during	IN
cord-006860-a3b8hyyr	4299	2	therapy	therapy	NN
cord-006860-a3b8hyyr	4299	3	to	to	IN
cord-006860-a3b8hyyr	4299	4	a	a	DT
cord-006860-a3b8hyyr	4299	5	maximum	maximum	JJ
cord-006860-a3b8hyyr	4299	6	level	level	NN
cord-006860-a3b8hyyr	4299	7	of	of	IN
cord-006860-a3b8hyyr	4299	8	260	260	CD
cord-006860-a3b8hyyr	4299	9	+	+	SYM
cord-006860-a3b8hyyr	4299	10	93	93	CD
cord-006860-a3b8hyyr	4299	11	10V~	10v~	CD
cord-006860-a3b8hyyr	4299	12	(	(	-LRB-
cord-006860-a3b8hyyr	4299	13	128	128	CD
cord-006860-a3b8hyyr	4299	14	%	%	NN
cord-006860-a3b8hyyr	4299	15	)	)	-RRB-
cord-006860-a3b8hyyr	4299	16	without	without	IN
cord-006860-a3b8hyyr	4299	17	any	any	DT
cord-006860-a3b8hyyr	4299	18	clinical	clinical	JJ
cord-006860-a3b8hyyr	4299	19	signs	sign	NNS
cord-006860-a3b8hyyr	4299	20	of	of	IN
cord-006860-a3b8hyyr	4299	21	thrombeembolism	thrombeembolism	NN
cord-006860-a3b8hyyr	4299	22	.	.	.
cord-006860-a3b8hyyr	4300	1	In	in	IN
cord-006860-a3b8hyyr	4300	2	the	the	DT
cord-006860-a3b8hyyr	4300	3	control	control	NN
cord-006860-a3b8hyyr	4300	4	group	group	NN
cord-006860-a3b8hyyr	4300	5	(	(	-LRB-
cord-006860-a3b8hyyr	4300	6	autologous	autologous	JJ
cord-006860-a3b8hyyr	4300	7	blood	blood	NN
cord-006860-a3b8hyyr	4300	8	donation	donation	NN
cord-006860-a3b8hyyr	4300	9	weekly	weekly	JJ
cord-006860-a3b8hyyr	4300	10	3	3	CD
cord-006860-a3b8hyyr	4300	11	or	or	CC
cord-006860-a3b8hyyr	4300	12	4	4	CD
cord-006860-a3b8hyyr	4300	13	times	time	NNS
cord-006860-a3b8hyyr	4300	14	without	without	IN
cord-006860-a3b8hyyr	4300	15	erythrupoiedn	erythrupoiedn	NN
cord-006860-a3b8hyyr	4300	16	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4300	17	,	,	,
cord-006860-a3b8hyyr	4300	18	n=12	n=12	NNP
cord-006860-a3b8hyyr	4300	19	)	)	-RRB-
cord-006860-a3b8hyyr	4300	20	platelets	platelet	NNS
cord-006860-a3b8hyyr	4300	21	increased	increase	VBD
cord-006860-a3b8hyyr	4300	22	from	from	IN
cord-006860-a3b8hyyr	4300	23	initially	initially	RB
cord-006860-a3b8hyyr	4300	24	230	230	CD
cord-006860-a3b8hyyr	4301	1	_	_	NNP
cord-006860-a3b8hyyr	4301	2	_	_	NNP
cord-006860-a3b8hyyr	4301	3	+	+	CC
cord-006860-a3b8hyyr	4302	1	73	73	CD
cord-006860-a3b8hyyr	4302	2	10'/FI	10'/fi	CD
cord-006860-a3b8hyyr	4302	3	(	(	-LRB-
cord-006860-a3b8hyyr	4302	4	100	100	CD
cord-006860-a3b8hyyr	4302	5	%	%	NN
cord-006860-a3b8hyyr	4302	6	)	)	-RRB-
cord-006860-a3b8hyyr	4302	7	to	to	IN
cord-006860-a3b8hyyr	4302	8	255	255	CD
cord-006860-a3b8hyyr	4302	9	+	+	SYM
cord-006860-a3b8hyyr	4302	10	71	71	CD
cord-006860-a3b8hyyr	4302	11	10V#I	10v#i	CD
cord-006860-a3b8hyyr	4302	12	(	(	-LRB-
cord-006860-a3b8hyyr	4302	13	110	110	CD
cord-006860-a3b8hyyr	4302	14	%	%	NN
cord-006860-a3b8hyyr	4302	15	)	)	-RRB-
cord-006860-a3b8hyyr	4303	1	I1]aximlzm	I1]aximlzm	NNP
cord-006860-a3b8hyyr	4303	2	Colldttsions	Colldttsions	NNP
cord-006860-a3b8hyyr	4303	3	:	:	:
cord-006860-a3b8hyyr	4304	1	The	the	DT
cord-006860-a3b8hyyr	4304	2	adlninist/'ation	adlninist/'ation	NN
cord-006860-a3b8hyyr	4304	3	of	of	IN
cord-006860-a3b8hyyr	4304	4	lhEPO	lhepo	NN
cord-006860-a3b8hyyr	4304	5	in	in	IN
cord-006860-a3b8hyyr	4304	6	the	the	DT
cord-006860-a3b8hyyr	4304	7	above	above	JJ
cord-006860-a3b8hyyr	4304	8	described	describe	VBN
cord-006860-a3b8hyyr	4304	9	manner	manner	NN
cord-006860-a3b8hyyr	4304	10	tO	to	IN
cord-006860-a3b8hyyr	4304	11	autologous	autologous	JJ
cord-006860-a3b8hyyr	4304	12	donors	donor	NNS
cord-006860-a3b8hyyr	4304	13	undergoing	undergo	VBG
cord-006860-a3b8hyyr	4304	14	heart	heart	NN
cord-006860-a3b8hyyr	4304	15	surgery	surgery	NN
cord-006860-a3b8hyyr	4304	16	is	be	VBZ
cord-006860-a3b8hyyr	4304	17	well	well	RB
cord-006860-a3b8hyyr	4304	18	tolerated	tolerate	VBN
cord-006860-a3b8hyyr	4304	19	.	.	.
cord-006860-a3b8hyyr	4305	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	4305	2	allows	allow	VBZ
cord-006860-a3b8hyyr	4305	3	to	to	TO
cord-006860-a3b8hyyr	4305	4	collect	collect	VB
cord-006860-a3b8hyyr	4305	5	a	a	DT
cord-006860-a3b8hyyr	4305	6	sufficient	sufficient	JJ
cord-006860-a3b8hyyr	4305	7	number	number	NN
cord-006860-a3b8hyyr	4305	8	of	of	IN
cord-006860-a3b8hyyr	4305	9	autologous	autologous	JJ
cord-006860-a3b8hyyr	4305	10	blood	blood	NN
cord-006860-a3b8hyyr	4305	11	units	unit	NNS
cord-006860-a3b8hyyr	4305	12	and	and	CC
cord-006860-a3b8hyyr	4305	13	the	the	DT
cord-006860-a3b8hyyr	4305	14	preparation	preparation	NN
cord-006860-a3b8hyyr	4305	15	of	of	IN
cord-006860-a3b8hyyr	4305	16	a	a	DT
cord-006860-a3b8hyyr	4305	17	predeposit	predeposit	NN
cord-006860-a3b8hyyr	4305	18	at	at	IN
cord-006860-a3b8hyyr	4305	19	short	short	JJ
cord-006860-a3b8hyyr	4305	20	notice	notice	NN
cord-006860-a3b8hyyr	4305	21	.	.	.
cord-006860-a3b8hyyr	4306	1	Essential	essential	JJ
cord-006860-a3b8hyyr	4306	2	thrombocythemia	thrombocythemia	NN
cord-006860-a3b8hyyr	4306	3	is	be	VBZ
cord-006860-a3b8hyyr	4306	4	a	a	DT
cord-006860-a3b8hyyr	4306	5	chronic	chronic	JJ
cord-006860-a3b8hyyr	4306	6	myeloproliferative	myeloproliferative	JJ
cord-006860-a3b8hyyr	4306	7	disease	disease	NN
cord-006860-a3b8hyyr	4306	8	with	with	IN
cord-006860-a3b8hyyr	4306	9	a	a	DT
cord-006860-a3b8hyyr	4306	10	benign	benign	JJ
cord-006860-a3b8hyyr	4306	11	clinical	clinical	JJ
cord-006860-a3b8hyyr	4306	12	course	course	NN
cord-006860-a3b8hyyr	4306	13	that	that	WDT
cord-006860-a3b8hyyr	4306	14	is	be	VBZ
cord-006860-a3b8hyyr	4306	15	mainly	mainly	RB
cord-006860-a3b8hyyr	4306	16	complicated	complicate	VBN
cord-006860-a3b8hyyr	4306	17	by	by	IN
cord-006860-a3b8hyyr	4306	18	microcirculatory	microcirculatory	JJ
cord-006860-a3b8hyyr	4306	19	or	or	CC
cord-006860-a3b8hyyr	4306	20	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	4306	21	vascular	vascular	JJ
cord-006860-a3b8hyyr	4306	22	disorders	disorder	NNS
cord-006860-a3b8hyyr	4306	23	.	.	.
cord-006860-a3b8hyyr	4307	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	4307	2	is	be	VBZ
cord-006860-a3b8hyyr	4307	3	at	at	IN
cord-006860-a3b8hyyr	4307	4	present	present	JJ
cord-006860-a3b8hyyr	4307	5	uncertain	uncertain	NN
cord-006860-a3b8hyyr	4307	6	which	which	WDT
cord-006860-a3b8hyyr	4307	7	patients	patient	NNS
cord-006860-a3b8hyyr	4307	8	need	need	VBP
cord-006860-a3b8hyyr	4307	9	(	(	-LRB-
cord-006860-a3b8hyyr	4307	10	lifelong	lifelong	JJ
cord-006860-a3b8hyyr	4307	11	)	)	-RRB-
cord-006860-a3b8hyyr	4307	12	therapy	therapy	NN
cord-006860-a3b8hyyr	4307	13	and	and	CC
cord-006860-a3b8hyyr	4307	14	whether	whether	IN
cord-006860-a3b8hyyr	4307	15	cytoreduction	cytoreduction	NN
cord-006860-a3b8hyyr	4307	16	is	be	VBZ
cord-006860-a3b8hyyr	4307	17	necessary	necessary	JJ
cord-006860-a3b8hyyr	4307	18	.	.	.
cord-006860-a3b8hyyr	4308	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4308	2	retrospectively	retrospectively	RB
cord-006860-a3b8hyyr	4308	3	evaluated	evaluate	VBD
cord-006860-a3b8hyyr	4308	4	vascular	vascular	JJ
cord-006860-a3b8hyyr	4308	5	complications	complication	NNS
cord-006860-a3b8hyyr	4308	6	in	in	IN
cord-006860-a3b8hyyr	4308	7	128	128	CD
cord-006860-a3b8hyyr	4308	8	patients	patient	NNS
cord-006860-a3b8hyyr	4308	9	(	(	-LRB-
cord-006860-a3b8hyyr	4308	10	33	33	CD
cord-006860-a3b8hyyr	4308	11	men	man	NNS
cord-006860-a3b8hyyr	4308	12	,	,	,
cord-006860-a3b8hyyr	4308	13	95	95	CD
cord-006860-a3b8hyyr	4308	14	women	woman	NNS
cord-006860-a3b8hyyr	4308	15	)	)	-RRB-
cord-006860-a3b8hyyr	4308	16	with	with	IN
cord-006860-a3b8hyyr	4308	17	a	a	DT
cord-006860-a3b8hyyr	4308	18	median	median	JJ
cord-006860-a3b8hyyr	4308	19	age	age	NN
cord-006860-a3b8hyyr	4308	20	of	of	IN
cord-006860-a3b8hyyr	4308	21	61	61	CD
cord-006860-a3b8hyyr	4308	22	years	year	NNS
cord-006860-a3b8hyyr	4308	23	in	in	IN
cord-006860-a3b8hyyr	4308	24	relation	relation	NN
cord-006860-a3b8hyyr	4308	25	to	to	IN
cord-006860-a3b8hyyr	4308	26	therapy	therapy	NN
cord-006860-a3b8hyyr	4308	27	.	.	.
cord-006860-a3b8hyyr	4309	1	Three	three	CD
cord-006860-a3b8hyyr	4309	2	major	major	JJ
cord-006860-a3b8hyyr	4309	3	treatment	treatment	NN
cord-006860-a3b8hyyr	4309	4	groups	group	NNS
cord-006860-a3b8hyyr	4309	5	were	be	VBD
cord-006860-a3b8hyyr	4309	6	analysed	analyse	VBN
cord-006860-a3b8hyyr	4309	7	:	:	:
cord-006860-a3b8hyyr	4309	8	17	17	CD
cord-006860-a3b8hyyr	4309	9	patients	patient	NNS
cord-006860-a3b8hyyr	4309	10	treated	treat	VBN
cord-006860-a3b8hyyr	4309	11	with	with	IN
cord-006860-a3b8hyyr	4309	12	acetylsalicylic	acetylsalicylic	JJ
cord-006860-a3b8hyyr	4309	13	acid	acid	NN
cord-006860-a3b8hyyr	4309	14	(	(	-LRB-
cord-006860-a3b8hyyr	4309	15	ASS	ass	NN
cord-006860-a3b8hyyr	4309	16	)	)	-RRB-
cord-006860-a3b8hyyr	4309	17	alone	alone	RB
cord-006860-a3b8hyyr	4309	18	,	,	,
cord-006860-a3b8hyyr	4309	19	29	29	CD
cord-006860-a3b8hyyr	4309	20	patients	patient	NNS
cord-006860-a3b8hyyr	4309	21	given	give	VBN
cord-006860-a3b8hyyr	4309	22	alkylating	alkylating	JJ
cord-006860-a3b8hyyr	4309	23	agents	agent	NNS
cord-006860-a3b8hyyr	4309	24	,	,	,
cord-006860-a3b8hyyr	4309	25	and	and	CC
cord-006860-a3b8hyyr	4309	26	62	62	CD
cord-006860-a3b8hyyr	4309	27	patients	patient	NNS
cord-006860-a3b8hyyr	4309	28	treated	treat	VBN
cord-006860-a3b8hyyr	4309	29	with	with	IN
cord-006860-a3b8hyyr	4309	30	interferon	interferon	NN
cord-006860-a3b8hyyr	4309	31	alpha	alpha	NN
cord-006860-a3b8hyyr	4309	32	(	(	-LRB-
cord-006860-a3b8hyyr	4309	33	IFN	IFN	NNP
cord-006860-a3b8hyyr	4309	34	)	)	-RRB-
cord-006860-a3b8hyyr	4309	35	.	.	.
cord-006860-a3b8hyyr	4310	1	There	there	EX
cord-006860-a3b8hyyr	4310	2	was	be	VBD
cord-006860-a3b8hyyr	4310	3	no	no	DT
cord-006860-a3b8hyyr	4310	4	significant	significant	JJ
cord-006860-a3b8hyyr	4310	5	number	number	NN
cord-006860-a3b8hyyr	4310	6	of	of	IN
cord-006860-a3b8hyyr	4310	7	patients	patient	NNS
cord-006860-a3b8hyyr	4310	8	treated	treat	VBN
cord-006860-a3b8hyyr	4310	9	with	with	IN
cord-006860-a3b8hyyr	4310	10	hydroxyurea	hydroxyurea	NNP
cord-006860-a3b8hyyr	4310	11	.	.	.
cord-006860-a3b8hyyr	4311	1	IFN	IFN	NNP
cord-006860-a3b8hyyr	4311	2	-	-	HYPH
cord-006860-a3b8hyyr	4311	3	treated	treat	VBN
cord-006860-a3b8hyyr	4311	4	patients	patient	NNS
cord-006860-a3b8hyyr	4311	5	were	be	VBD
cord-006860-a3b8hyyr	4311	6	younger	young	JJR
cord-006860-a3b8hyyr	4311	7	(	(	-LRB-
cord-006860-a3b8hyyr	4311	8	median	median	JJ
cord-006860-a3b8hyyr	4311	9	age	age	NN
cord-006860-a3b8hyyr	4311	10	54	54	CD
cord-006860-a3b8hyyr	4311	11	years	year	NNS
cord-006860-a3b8hyyr	4311	12	)	)	-RRB-
cord-006860-a3b8hyyr	4311	13	than	than	IN
cord-006860-a3b8hyyr	4311	14	patients	patient	NNS
cord-006860-a3b8hyyr	4311	15	in	in	IN
cord-006860-a3b8hyyr	4311	16	the	the	DT
cord-006860-a3b8hyyr	4311	17	other	other	JJ
cord-006860-a3b8hyyr	4311	18	groups	group	NNS
cord-006860-a3b8hyyr	4311	19	,	,	,
cord-006860-a3b8hyyr	4311	20	but	but	CC
cord-006860-a3b8hyyr	4311	21	platelet	platelet	NN
cord-006860-a3b8hyyr	4311	22	counts	count	NNS
cord-006860-a3b8hyyr	4311	23	before	before	IN
cord-006860-a3b8hyyr	4311	24	therapy	therapy	NN
cord-006860-a3b8hyyr	4311	25	were	be	VBD
cord-006860-a3b8hyyr	4311	26	similar	similar	JJ
cord-006860-a3b8hyyr	4311	27	(	(	-LRB-
cord-006860-a3b8hyyr	4311	28	median	median	JJ
cord-006860-a3b8hyyr	4311	29	0.84	0.84	CD
cord-006860-a3b8hyyr	4311	30	-	-	SYM
cord-006860-a3b8hyyr	4311	31	1.13	1.13	CD
cord-006860-a3b8hyyr	4312	1	x	x	LS
cord-006860-a3b8hyyr	4312	2	1012	1012	CD
cord-006860-a3b8hyyr	4312	3	/	/	SYM
cord-006860-a3b8hyyr	4312	4	I	i	NN
cord-006860-a3b8hyyr	4312	5	)	)	-RRB-
cord-006860-a3b8hyyr	4312	6	.	.	.
cord-006860-a3b8hyyr	4313	1	Before	before	IN
cord-006860-a3b8hyyr	4313	2	therapy	therapy	NN
cord-006860-a3b8hyyr	4313	3	,	,	,
cord-006860-a3b8hyyr	4313	4	47	47	CD
cord-006860-a3b8hyyr	4313	5	%	%	NN
cord-006860-a3b8hyyr	4313	6	of	of	IN
cord-006860-a3b8hyyr	4313	7	patients	patient	NNS
cord-006860-a3b8hyyr	4313	8	treated	treat	VBN
cord-006860-a3b8hyyr	4313	9	with	with	IN
cord-006860-a3b8hyyr	4313	10	ASS	ass	NN
cord-006860-a3b8hyyr	4313	11	,	,	,
cord-006860-a3b8hyyr	4313	12	45	45	CD
cord-006860-a3b8hyyr	4313	13	%	%	NN
cord-006860-a3b8hyyr	4313	14	treated	treat	VBN
cord-006860-a3b8hyyr	4313	15	with	with	IN
cord-006860-a3b8hyyr	4313	16	alkylating	alkylating	JJ
cord-006860-a3b8hyyr	4313	17	drugs	drug	NNS
cord-006860-a3b8hyyr	4313	18	,	,	,
cord-006860-a3b8hyyr	4313	19	and	and	CC
cord-006860-a3b8hyyr	4313	20	32	32	CD
cord-006860-a3b8hyyr	4313	21	%	%	NN
cord-006860-a3b8hyyr	4313	22	treated	treat	VBN
cord-006860-a3b8hyyr	4313	23	with	with	IN
cord-006860-a3b8hyyr	4313	24	IFN	IFN	NNP
cord-006860-a3b8hyyr	4313	25	had	have	VBD
cord-006860-a3b8hyyr	4313	26	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4313	27	events	event	NNS
cord-006860-a3b8hyyr	4313	28	,	,	,
cord-006860-a3b8hyyr	4313	29	microcirculatory	microcirculatory	JJ
cord-006860-a3b8hyyr	4313	30	or	or	CC
cord-006860-a3b8hyyr	4313	31	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	4313	32	complications	complication	NNS
cord-006860-a3b8hyyr	4313	33	.	.	.
cord-006860-a3b8hyyr	4314	1	Dudng	Dudng	NNP
cord-006860-a3b8hyyr	4314	2	therapy	therapy	NN
cord-006860-a3b8hyyr	4314	3	,	,	,
cord-006860-a3b8hyyr	4314	4	median	median	JJ
cord-006860-a3b8hyyr	4314	5	platelet	platelet	NN
cord-006860-a3b8hyyr	4314	6	count	count	NN
cord-006860-a3b8hyyr	4314	7	was	be	VBD
cord-006860-a3b8hyyr	4314	8	0.9	0.9	CD
cord-006860-a3b8hyyr	4315	1	x	x	LS
cord-006860-a3b8hyyr	4315	2	1012	1012	CD
cord-006860-a3b8hyyr	4316	1	/I	/i	NN
cord-006860-a3b8hyyr	4316	2	in	in	IN
cord-006860-a3b8hyyr	4316	3	patients	patient	NNS
cord-006860-a3b8hyyr	4316	4	on	on	IN
cord-006860-a3b8hyyr	4316	5	ASS	ass	NN
cord-006860-a3b8hyyr	4316	6	,	,	,
cord-006860-a3b8hyyr	4316	7	0.68	0.68	CD
cord-006860-a3b8hyyr	4316	8	x	x	SYM
cord-006860-a3b8hyyr	4316	9	1012	1012	CD
cord-006860-a3b8hyyr	4316	10	/	/	SYM
cord-006860-a3b8hyyr	4316	11	I	-PRON-	PRP
cord-006860-a3b8hyyr	4316	12	in	in	IN
cord-006860-a3b8hyyr	4316	13	patients	patient	NNS
cord-006860-a3b8hyyr	4316	14	treated	treat	VBN
cord-006860-a3b8hyyr	4316	15	with	with	IN
cord-006860-a3b8hyyr	4316	16	alkylants	alkylant	NNS
cord-006860-a3b8hyyr	4316	17	,	,	,
cord-006860-a3b8hyyr	4316	18	and	and	CC
cord-006860-a3b8hyyr	4316	19	0.48	0.48	CD
cord-006860-a3b8hyyr	4316	20	x	x	SYM
cord-006860-a3b8hyyr	4316	21	1012	1012	CD
cord-006860-a3b8hyyr	4316	22	/	/	SYM
cord-006860-a3b8hyyr	4316	23	I	-PRON-	PRP
cord-006860-a3b8hyyr	4316	24	in	in	IN
cord-006860-a3b8hyyr	4316	25	IFN	IFN	NNP
cord-006860-a3b8hyyr	4316	26	-	-	HYPH
cord-006860-a3b8hyyr	4316	27	teated	teate	VBN
cord-006860-a3b8hyyr	4316	28	patients	patient	NNS
cord-006860-a3b8hyyr	4316	29	.	.	.
cord-006860-a3b8hyyr	4317	1	The	the	DT
cord-006860-a3b8hyyr	4317	2	rate	rate	NN
cord-006860-a3b8hyyr	4317	3	of	of	IN
cord-006860-a3b8hyyr	4317	4	patients	patient	NNS
cord-006860-a3b8hyyr	4317	5	with	with	IN
cord-006860-a3b8hyyr	4317	6	complications	complication	NNS
cord-006860-a3b8hyyr	4317	7	during	during	IN
cord-006860-a3b8hyyr	4317	8	therapy	therapy	NN
cord-006860-a3b8hyyr	4317	9	was	be	VBD
cord-006860-a3b8hyyr	4317	10	18	18	CD
cord-006860-a3b8hyyr	4317	11	%	%	NN
cord-006860-a3b8hyyr	4317	12	(	(	-LRB-
cord-006860-a3b8hyyr	4317	13	9.5%/patient	9.5%/patient	CD
cord-006860-a3b8hyyr	4317	14	year	year	NN
cord-006860-a3b8hyyr	4317	15	)	)	-RRB-
cord-006860-a3b8hyyr	4317	16	for	for	IN
cord-006860-a3b8hyyr	4317	17	ASS	ass	NN
cord-006860-a3b8hyyr	4317	18	,	,	,
cord-006860-a3b8hyyr	4317	19	14	14	CD
cord-006860-a3b8hyyr	4317	20	%	%	NN
cord-006860-a3b8hyyr	4317	21	(	(	-LRB-
cord-006860-a3b8hyyr	4317	22	6.3%/patient	6.3%/patient	CD
cord-006860-a3b8hyyr	4317	23	year	year	NN
cord-006860-a3b8hyyr	4317	24	)	)	-RRB-
cord-006860-a3b8hyyr	4317	25	for	for	IN
cord-006860-a3b8hyyr	4317	26	patients	patient	NNS
cord-006860-a3b8hyyr	4317	27	on	on	IN
cord-006860-a3b8hyyr	4317	28	alkylating	alkylating	JJ
cord-006860-a3b8hyyr	4317	29	drugs	drug	NNS
cord-006860-a3b8hyyr	4317	30	,	,	,
cord-006860-a3b8hyyr	4317	31	and	and	CC
cord-006860-a3b8hyyr	4317	32	15	15	CD
cord-006860-a3b8hyyr	4317	33	%	%	NN
cord-006860-a3b8hyyr	4317	34	(	(	-LRB-
cord-006860-a3b8hyyr	4317	35	6.2	6.2	CD
cord-006860-a3b8hyyr	4317	36	°	°	NN
cord-006860-a3b8hyyr	4317	37	/dpatient	/dpatient	NNP
cord-006860-a3b8hyyr	4317	38	year	year	NN
cord-006860-a3b8hyyr	4317	39	)	)	-RRB-
cord-006860-a3b8hyyr	4317	40	for	for	IN
cord-006860-a3b8hyyr	4317	41	IFN	IFN	NNP
cord-006860-a3b8hyyr	4317	42	-	-	HYPH
cord-006860-a3b8hyyr	4317	43	treated	treat	VBN
cord-006860-a3b8hyyr	4317	44	patients	patient	NNS
cord-006860-a3b8hyyr	4317	45	.	.	.
cord-006860-a3b8hyyr	4318	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4318	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	4318	3	that	that	IN
cord-006860-a3b8hyyr	4318	4	all	all	DT
cord-006860-a3b8hyyr	4318	5	three	three	CD
cord-006860-a3b8hyyr	4318	6	treatment	treatment	NN
cord-006860-a3b8hyyr	4318	7	regimes	regime	NNS
cord-006860-a3b8hyyr	4318	8	seemed	seem	VBD
cord-006860-a3b8hyyr	4318	9	to	to	TO
cord-006860-a3b8hyyr	4318	10	have	have	VB
cord-006860-a3b8hyyr	4318	11	a	a	DT
cord-006860-a3b8hyyr	4318	12	beneficial	beneficial	JJ
cord-006860-a3b8hyyr	4318	13	effect	effect	NN
cord-006860-a3b8hyyr	4318	14	on	on	IN
cord-006860-a3b8hyyr	4318	15	the	the	DT
cord-006860-a3b8hyyr	4318	16	incidence	incidence	NN
cord-006860-a3b8hyyr	4318	17	of	of	IN
cord-006860-a3b8hyyr	4318	18	vascular	vascular	JJ
cord-006860-a3b8hyyr	4318	19	complications	complication	NNS
cord-006860-a3b8hyyr	4318	20	in	in	IN
cord-006860-a3b8hyyr	4318	21	essential	essential	JJ
cord-006860-a3b8hyyr	4318	22	thrombocythemia	thrombocythemia	NN
cord-006860-a3b8hyyr	4318	23	.	.	.
cord-006860-a3b8hyyr	4319	1	The	the	DT
cord-006860-a3b8hyyr	4319	2	results	result	NNS
cord-006860-a3b8hyyr	4319	3	give	give	VBP
cord-006860-a3b8hyyr	4319	4	a	a	DT
cord-006860-a3b8hyyr	4319	5	rough	rough	JJ
cord-006860-a3b8hyyr	4319	6	estimate	estimate	NN
cord-006860-a3b8hyyr	4319	7	of	of	IN
cord-006860-a3b8hyyr	4319	8	complication	complication	NN
cord-006860-a3b8hyyr	4319	9	rates	rate	NNS
cord-006860-a3b8hyyr	4319	10	to	to	TO
cord-006860-a3b8hyyr	4319	11	be	be	VB
cord-006860-a3b8hyyr	4319	12	expected	expect	VBN
cord-006860-a3b8hyyr	4319	13	and	and	CC
cord-006860-a3b8hyyr	4319	14	may	may	MD
cord-006860-a3b8hyyr	4319	15	form	form	VB
cord-006860-a3b8hyyr	4319	16	the	the	DT
cord-006860-a3b8hyyr	4319	17	basis	basis	NN
cord-006860-a3b8hyyr	4319	18	for	for	IN
cord-006860-a3b8hyyr	4319	19	randomized	randomized	JJ
cord-006860-a3b8hyyr	4319	20	clinical	clinical	JJ
cord-006860-a3b8hyyr	4319	21	trials	trial	NNS
cord-006860-a3b8hyyr	4319	22	.	.	.
cord-006860-a3b8hyyr	4320	1	Adhesion	adhesion	NN
cord-006860-a3b8hyyr	4320	2	of	of	IN
cord-006860-a3b8hyyr	4320	3	activated	activate	VBN
cord-006860-a3b8hyyr	4320	4	platelets	platelet	NNS
cord-006860-a3b8hyyr	4320	5	to	to	IN
cord-006860-a3b8hyyr	4320	6	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	4320	7	*	*	NFP
cord-006860-a3b8hyyr	4320	8	has	have	VBZ
cord-006860-a3b8hyyr	4320	9	been	be	VBN
cord-006860-a3b8hyyr	4320	10	shown	show	VBN
cord-006860-a3b8hyyr	4320	11	to	to	TO
cord-006860-a3b8hyyr	4320	12	be	be	VB
cord-006860-a3b8hyyr	4320	13	mediated	mediate	VBN
cord-006860-a3b8hyyr	4320	14	by	by	IN
cord-006860-a3b8hyyr	4320	15	at	at	RB
cord-006860-a3b8hyyr	4320	16	least	least	RBS
cord-006860-a3b8hyyr	4320	17	two	two	CD
cord-006860-a3b8hyyr	4320	18	molecules	molecule	NNS
cord-006860-a3b8hyyr	4320	19	on	on	IN
cord-006860-a3b8hyyr	4320	20	the	the	DT
cord-006860-a3b8hyyr	4320	21	platelet	platelet	NN
cord-006860-a3b8hyyr	4320	22	surface	surface	NN
cord-006860-a3b8hyyr	4320	23	:	:	:
cord-006860-a3b8hyyr	4320	24	P	p	NN
cord-006860-a3b8hyyr	4320	25	-	-	HYPH
cord-006860-a3b8hyyr	4320	26	selectin	selectin	NNP
cord-006860-a3b8hyyr	4320	27	(	(	-LRB-
cord-006860-a3b8hyyr	4320	28	CD62	CD62	NNP
cord-006860-a3b8hyyr	4320	29	)	)	-RRB-
cord-006860-a3b8hyyr	4320	30	and	and	CC
cord-006860-a3b8hyyr	4320	31	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4320	32	(	(	-LRB-
cord-006860-a3b8hyyr	4320	33	Fg	Fg	NNP
cord-006860-a3b8hyyr	4320	34	)	)	-RRB-
cord-006860-a3b8hyyr	4320	35	bound	bind	VBN
cord-006860-a3b8hyyr	4320	36	to	to	IN
cord-006860-a3b8hyyr	4320	37	the	the	DT
cord-006860-a3b8hyyr	4320	38	GP	GP	NNP
cord-006860-a3b8hyyr	4320	39	IIb	IIb	NNP
cord-006860-a3b8hyyr	4320	40	/	/	SYM
cord-006860-a3b8hyyr	4320	41	IIIa	iiia	NN
cord-006860-a3b8hyyr	4320	42	complex	complex	NN
cord-006860-a3b8hyyr	4320	43	.	.	.
cord-006860-a3b8hyyr	4321	1	Interaction	interaction	NN
cord-006860-a3b8hyyr	4321	2	of	of	IN
cord-006860-a3b8hyyr	4321	3	platelets	platelet	NNS
cord-006860-a3b8hyyr	4321	4	with	with	IN
cord-006860-a3b8hyyr	4321	5	teukocytes	teukocyte	NNS
cord-006860-a3b8hyyr	4321	6	via	via	IN
cord-006860-a3b8hyyr	4321	7	CD62	CD62	NNP
cord-006860-a3b8hyyr	4321	8	is	be	VBZ
cord-006860-a3b8hyyr	4321	9	believed	believe	VBN
cord-006860-a3b8hyyr	4321	10	to	to	TO
cord-006860-a3b8hyyr	4321	11	stimulate	stimulate	VB
cord-006860-a3b8hyyr	4321	12	the	the	DT
cord-006860-a3b8hyyr	4321	13	production	production	NN
cord-006860-a3b8hyyr	4321	14	of	of	IN
cord-006860-a3b8hyyr	4321	15	reactive	reactive	JJ
cord-006860-a3b8hyyr	4321	16	oxygen	oxygen	NN
cord-006860-a3b8hyyr	4321	17	species	specie	NNS
cord-006860-a3b8hyyr	4321	18	(	(	-LRB-
cord-006860-a3b8hyyr	4321	19	ROS	ROS	NNP
cord-006860-a3b8hyyr	4321	20	)	)	-RRB-
cord-006860-a3b8hyyr	4321	21	in	in	IN
cord-006860-a3b8hyyr	4321	22	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	4321	23	*	*	NFP
cord-006860-a3b8hyyr	4321	24	.	.	.
cord-006860-a3b8hyyr	4322	1	The	the	DT
cord-006860-a3b8hyyr	4322	2	role	role	NN
cord-006860-a3b8hyyr	4322	3	of	of	IN
cord-006860-a3b8hyyr	4322	4	platetet	platetet	NN
cord-006860-a3b8hyyr	4322	5	-	-	HYPH
cord-006860-a3b8hyyr	4322	6	bound	bind	VBN
cord-006860-a3b8hyyr	4322	7	Fg	Fg	NNP
cord-006860-a3b8hyyr	4322	8	as	as	IN
cord-006860-a3b8hyyr	4322	9	a	a	DT
cord-006860-a3b8hyyr	4322	10	signalling	signal	VBG
cord-006860-a3b8hyyr	4322	11	molecule	molecule	NN
cord-006860-a3b8hyyr	4322	12	in	in	IN
cord-006860-a3b8hyyr	4322	13	platelet	platelet	NN
cord-006860-a3b8hyyr	4322	14	-	-	HYPH
cord-006860-a3b8hyyr	4322	15	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	4322	16	interaction	interaction	NN
cord-006860-a3b8hyyr	4322	17	is	be	VBZ
cord-006860-a3b8hyyr	4322	18	controversially	controversially	RB
cord-006860-a3b8hyyr	4322	19	discussed	discuss	VBN
cord-006860-a3b8hyyr	4322	20	:	:	:
cord-006860-a3b8hyyr	4322	21	stimulatory	stimulatory	JJ
cord-006860-a3b8hyyr	4322	22	as	as	RB
cord-006860-a3b8hyyr	4322	23	well	well	RB
cord-006860-a3b8hyyr	4322	24	as	as	IN
cord-006860-a3b8hyyr	4322	25	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	4322	26	effects	effect	NNS
cord-006860-a3b8hyyr	4322	27	on	on	IN
cord-006860-a3b8hyyr	4322	28	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	4322	29	ROS	ROS	NNP
cord-006860-a3b8hyyr	4322	30	production	production	NN
cord-006860-a3b8hyyr	4322	31	has	have	VBZ
cord-006860-a3b8hyyr	4322	32	been	be	VBN
cord-006860-a3b8hyyr	4322	33	described	describe	VBN
cord-006860-a3b8hyyr	4322	34	.	.	.
cord-006860-a3b8hyyr	4323	1	In	in	IN
cord-006860-a3b8hyyr	4323	2	the	the	DT
cord-006860-a3b8hyyr	4323	3	present	present	JJ
cord-006860-a3b8hyyr	4323	4	study	study	NN
cord-006860-a3b8hyyr	4323	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	4323	6	measured	measure	VBD
cord-006860-a3b8hyyr	4323	7	ROS	ROS	NNP
cord-006860-a3b8hyyr	4323	8	production	production	NN
cord-006860-a3b8hyyr	4323	9	in	in	IN
cord-006860-a3b8hyyr	4323	10	undiluted	undiluted	JJ
cord-006860-a3b8hyyr	4323	11	samples	sample	NNS
cord-006860-a3b8hyyr	4323	12	of	of	IN
cord-006860-a3b8hyyr	4323	13	citrated	citrated	JJ
cord-006860-a3b8hyyr	4323	14	whole	whole	JJ
cord-006860-a3b8hyyr	4323	15	blood	blood	NN
cord-006860-a3b8hyyr	4323	16	(	(	-LRB-
cord-006860-a3b8hyyr	4323	17	WB	WB	NNP
cord-006860-a3b8hyyr	4323	18	)	)	-RRB-
cord-006860-a3b8hyyr	4323	19	as	as	RB
cord-006860-a3b8hyyr	4323	20	well	well	RB
cord-006860-a3b8hyyr	4323	21	as	as	IN
cord-006860-a3b8hyyr	4323	22	in	in	IN
cord-006860-a3b8hyyr	4323	23	suspensions	suspension	NNS
cord-006860-a3b8hyyr	4323	24	of	of	IN
cord-006860-a3b8hyyr	4323	25	erythrocytes	erythrocyte	NNS
cord-006860-a3b8hyyr	4323	26	and	and	CC
cord-006860-a3b8hyyr	4323	27	leukocytes	leukocyte	NNS
cord-006860-a3b8hyyr	4323	28	in	in	IN
cord-006860-a3b8hyyr	4323	29	platelet	platelet	NN
cord-006860-a3b8hyyr	4323	30	-	-	HYPH
cord-006860-a3b8hyyr	4323	31	rich	rich	JJ
cord-006860-a3b8hyyr	4323	32	plasma	plasma	NN
cord-006860-a3b8hyyr	4323	33	(	(	-LRB-
cord-006860-a3b8hyyr	4323	34	platelet	platelet	NN
cord-006860-a3b8hyyr	4323	35	-	-	HYPH
cord-006860-a3b8hyyr	4323	36	rich	rich	JJ
cord-006860-a3b8hyyr	4323	37	WB	WB	NNP
cord-006860-a3b8hyyr	4323	38	)	)	-RRB-
cord-006860-a3b8hyyr	4323	39	or	or	CC
cord-006860-a3b8hyyr	4323	40	platelet	platelet	NN
cord-006860-a3b8hyyr	4323	41	-	-	HYPH
cord-006860-a3b8hyyr	4323	42	poor	poor	JJ
cord-006860-a3b8hyyr	4323	43	plasma	plasma	NN
cord-006860-a3b8hyyr	4323	44	(	(	-LRB-
cord-006860-a3b8hyyr	4323	45	ptatelet	ptatelet	NN
cord-006860-a3b8hyyr	4323	46	-	-	HYPH
cord-006860-a3b8hyyr	4323	47	poor	poor	JJ
cord-006860-a3b8hyyr	4323	48	WB	WB	NNP
cord-006860-a3b8hyyr	4323	49	)	)	-RRB-
cord-006860-a3b8hyyr	4323	50	.	.	.
cord-006860-a3b8hyyr	4324	1	ROS	ROS	NNP
cord-006860-a3b8hyyr	4324	2	production	production	NN
cord-006860-a3b8hyyr	4324	3	was	be	VBD
cord-006860-a3b8hyyr	4324	4	determined	determine	VBN
cord-006860-a3b8hyyr	4324	5	by	by	IN
cord-006860-a3b8hyyr	4324	6	measuring	measure	VBG
cord-006860-a3b8hyyr	4324	7	luminol	luminol	NN
cord-006860-a3b8hyyr	4324	8	-	-	HYPH
cord-006860-a3b8hyyr	4324	9	enhanced	enhance	VBN
cord-006860-a3b8hyyr	4324	10	chemiluminescence	chemiluminescence	NN
cord-006860-a3b8hyyr	4324	11	(	(	-LRB-
cord-006860-a3b8hyyr	4324	12	CL	CL	NNP
cord-006860-a3b8hyyr	4324	13	)	)	-RRB-
cord-006860-a3b8hyyr	4324	14	.	.	.
cord-006860-a3b8hyyr	4325	1	Stirring	stirring	JJ
cord-006860-a3b8hyyr	4325	2	WB	WB	NNP
cord-006860-a3b8hyyr	4325	3	samples	sample	NNS
cord-006860-a3b8hyyr	4325	4	at	at	IN
cord-006860-a3b8hyyr	4325	5	1,000	1,000	CD
cord-006860-a3b8hyyr	4325	6	rpm	rpm	NN
cord-006860-a3b8hyyr	4325	7	for	for	IN
cord-006860-a3b8hyyr	4325	8	10	10	CD
cord-006860-a3b8hyyr	4325	9	min	min	NN
cord-006860-a3b8hyyr	4325	10	resulted	result	VBD
cord-006860-a3b8hyyr	4325	11	in	in	IN
cord-006860-a3b8hyyr	4325	12	an	an	DT
cord-006860-a3b8hyyr	4325	13	activation	activation	NN
cord-006860-a3b8hyyr	4325	14	of	of	IN
cord-006860-a3b8hyyr	4325	15	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	4325	16	*	*	NFP
cord-006860-a3b8hyyr	4326	1	(	(	-LRB-
cord-006860-a3b8hyyr	4326	2	increase	increase	NN
cord-006860-a3b8hyyr	4326	3	of	of	IN
cord-006860-a3b8hyyr	4326	4	CL	CL	NNP
cord-006860-a3b8hyyr	4326	5	,	,	,
cord-006860-a3b8hyyr	4326	6	upregulation	upregulation	NN
cord-006860-a3b8hyyr	4326	7	of	of	IN
cord-006860-a3b8hyyr	4326	8	CD1	CD1	NNP
cord-006860-a3b8hyyr	4326	9	lb	lb	CD
cord-006860-a3b8hyyr	4326	10	)	)	-RRB-
cord-006860-a3b8hyyr	4326	11	and	and	CC
cord-006860-a3b8hyyr	4326	12	platelets	platelet	NNS
cord-006860-a3b8hyyr	4326	13	(	(	-LRB-
cord-006860-a3b8hyyr	4326	14	platelet	platelet	NN
cord-006860-a3b8hyyr	4326	15	aggregation	aggregation	NN
cord-006860-a3b8hyyr	4326	16	,	,	,
cord-006860-a3b8hyyr	4326	17	upregulation	upregulation	NN
cord-006860-a3b8hyyr	4326	18	of	of	IN
cord-006860-a3b8hyyr	4326	19	CD62	CD62	NNP
cord-006860-a3b8hyyr	4326	20	)	)	-RRB-
cord-006860-a3b8hyyr	4326	21	.	.	.
cord-006860-a3b8hyyr	4327	1	Stirring	stirring	NN
cord-006860-a3b8hyyr	4327	2	-	-	HYPH
cord-006860-a3b8hyyr	4327	3	induced	induce	VBN
cord-006860-a3b8hyyr	4327	4	CL	CL	NNP
cord-006860-a3b8hyyr	4327	5	was	be	VBD
cord-006860-a3b8hyyr	4327	6	significantly	significantly	RB
cord-006860-a3b8hyyr	4327	7	higher	high	JJR
cord-006860-a3b8hyyr	4327	8	in	in	IN
cord-006860-a3b8hyyr	4327	9	platelet	platelet	NN
cord-006860-a3b8hyyr	4327	10	-	-	HYPH
cord-006860-a3b8hyyr	4327	11	poor	poor	JJ
cord-006860-a3b8hyyr	4327	12	WB	WB	NNP
cord-006860-a3b8hyyr	4327	13	when	when	WRB
cord-006860-a3b8hyyr	4327	14	compared	compare	VBN
cord-006860-a3b8hyyr	4327	15	to	to	IN
cord-006860-a3b8hyyr	4327	16	platelet	platelet	NN
cord-006860-a3b8hyyr	4327	17	-	-	HYPH
cord-006860-a3b8hyyr	4327	18	rich	rich	JJ
cord-006860-a3b8hyyr	4327	19	WB	WB	NNP
cord-006860-a3b8hyyr	4327	20	.	.	.
cord-006860-a3b8hyyr	4328	1	Higher	high	JJR
cord-006860-a3b8hyyr	4328	2	CL	CL	NNP
cord-006860-a3b8hyyr	4328	3	in	in	IN
cord-006860-a3b8hyyr	4328	4	plateletpoor	plateletpoor	JJ
cord-006860-a3b8hyyr	4328	5	WB	WB	NNP
cord-006860-a3b8hyyr	4328	6	than	than	IN
cord-006860-a3b8hyyr	4328	7	in	in	IN
cord-006860-a3b8hyyr	4328	8	platelet	platelet	NN
cord-006860-a3b8hyyr	4328	9	-	-	HYPH
cord-006860-a3b8hyyr	4328	10	rich	rich	JJ
cord-006860-a3b8hyyr	4328	11	WB	WB	NNP
cord-006860-a3b8hyyr	4328	12	was	be	VBD
cord-006860-a3b8hyyr	4328	13	also	also	RB
cord-006860-a3b8hyyr	4328	14	found	find	VBN
cord-006860-a3b8hyyr	4328	15	when	when	WRB
cord-006860-a3b8hyyr	4328	16	ADP	ADP	NNP
cord-006860-a3b8hyyr	4328	17	(	(	-LRB-
cord-006860-a3b8hyyr	4328	18	moderate	moderate	JJ
cord-006860-a3b8hyyr	4328	19	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4328	20	of	of	IN
cord-006860-a3b8hyyr	4328	21	platelets	platelet	NNS
cord-006860-a3b8hyyr	4328	22	and	and	CC
cord-006860-a3b8hyyr	4328	23	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	4328	24	*	*	NFP
cord-006860-a3b8hyyr	4328	25	)	)	-RRB-
cord-006860-a3b8hyyr	4328	26	or	or	CC
cord-006860-a3b8hyyr	4328	27	FMLP	FMLP	NNP
cord-006860-a3b8hyyr	4328	28	(	(	-LRB-
cord-006860-a3b8hyyr	4328	29	strong	strong	JJ
cord-006860-a3b8hyyr	4328	30	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4328	31	of	of	IN
cord-006860-a3b8hyyr	4328	32	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	4328	33	*	*	NFP
cord-006860-a3b8hyyr	4328	34	)	)	-RRB-
cord-006860-a3b8hyyr	4328	35	but	but	CC
cord-006860-a3b8hyyr	4328	36	not	not	RB
cord-006860-a3b8hyyr	4328	37	when	when	WRB
cord-006860-a3b8hyyr	4328	38	PMA	PMA	NNP
cord-006860-a3b8hyyr	4328	39	(	(	-LRB-
cord-006860-a3b8hyyr	4328	40	strong	strong	JJ
cord-006860-a3b8hyyr	4328	41	platelet	platelet	NN
cord-006860-a3b8hyyr	4328	42	and	and	CC
cord-006860-a3b8hyyr	4328	43	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	4328	44	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4328	45	)	)	-RRB-
cord-006860-a3b8hyyr	4328	46	was	be	VBD
cord-006860-a3b8hyyr	4328	47	added	add	VBN
cord-006860-a3b8hyyr	4328	48	.	.	.
cord-006860-a3b8hyyr	4329	1	Dextran	dextran	NN
cord-006860-a3b8hyyr	4329	2	sulphate	sulphate	NN
cord-006860-a3b8hyyr	4329	3	that	that	WDT
cord-006860-a3b8hyyr	4329	4	is	be	VBZ
cord-006860-a3b8hyyr	4329	5	known	know	VBN
cord-006860-a3b8hyyr	4329	6	to	to	TO
cord-006860-a3b8hyyr	4329	7	block	block	VB
cord-006860-a3b8hyyr	4329	8	CD62-mediated	cd62-mediated	JJ
cord-006860-a3b8hyyr	4329	9	interaction	interaction	NN
cord-006860-a3b8hyyr	4329	10	ofplatelets	ofplatelet	NNS
cord-006860-a3b8hyyr	4329	11	with	with	IN
cord-006860-a3b8hyyr	4329	12	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	4329	13	*	*	NFP
cord-006860-a3b8hyyr	4329	14	caused	cause	VBD
cord-006860-a3b8hyyr	4329	15	a	a	DT
cord-006860-a3b8hyyr	4329	16	dose	dose	NN
cord-006860-a3b8hyyr	4329	17	-	-	HYPH
cord-006860-a3b8hyyr	4329	18	dependent	dependent	JJ
cord-006860-a3b8hyyr	4329	19	inhibition	inhibition	NN
cord-006860-a3b8hyyr	4329	20	of	of	IN
cord-006860-a3b8hyyr	4329	21	stirring	stirring	NN
cord-006860-a3b8hyyr	4329	22	-	-	HYPH
cord-006860-a3b8hyyr	4329	23	induced	induce	VBN
cord-006860-a3b8hyyr	4329	24	CL	CL	NNP
cord-006860-a3b8hyyr	4329	25	in	in	IN
cord-006860-a3b8hyyr	4329	26	WB	WB	NNP
cord-006860-a3b8hyyr	4329	27	samples	sample	NNS
cord-006860-a3b8hyyr	4329	28	.	.	.
cord-006860-a3b8hyyr	4330	1	In	in	IN
cord-006860-a3b8hyyr	4330	2	contrast	contrast	NN
cord-006860-a3b8hyyr	4330	3	,	,	,
cord-006860-a3b8hyyr	4330	4	when	when	WRB
cord-006860-a3b8hyyr	4330	5	binding	bind	VBG
cord-006860-a3b8hyyr	4330	6	of	of	IN
cord-006860-a3b8hyyr	4330	7	Fg	Fg	NNP
cord-006860-a3b8hyyr	4330	8	to	to	IN
cord-006860-a3b8hyyr	4330	9	the	the	DT
cord-006860-a3b8hyyr	4330	10	platelet	platelet	NN
cord-006860-a3b8hyyr	4330	11	surface	surface	NN
cord-006860-a3b8hyyr	4330	12	was	be	VBD
cord-006860-a3b8hyyr	4330	13	blocked	block	VBN
cord-006860-a3b8hyyr	4330	14	by	by	IN
cord-006860-a3b8hyyr	4330	15	RGDS	RGDS	NNP
cord-006860-a3b8hyyr	4330	16	or	or	CC
cord-006860-a3b8hyyr	4330	17	the	the	DT
cord-006860-a3b8hyyr	4330	18	Fg	Fg	NNP
cord-006860-a3b8hyyr	4330	19	receptor	receptor	NN
cord-006860-a3b8hyyr	4330	20	antagonist	antagonist	NN
cord-006860-a3b8hyyr	4330	21	GR144053	gr144053	NN
cord-006860-a3b8hyyr	4330	22	,	,	,
cord-006860-a3b8hyyr	4330	23	stirring	stir	VBG
cord-006860-a3b8hyyr	4330	24	-	-	HYPH
cord-006860-a3b8hyyr	4330	25	induced	induce	VBN
cord-006860-a3b8hyyr	4330	26	CL	CL	NNP
cord-006860-a3b8hyyr	4330	27	,	,	,
cord-006860-a3b8hyyr	4330	28	but	but	CC
cord-006860-a3b8hyyr	4330	29	not	not	RB
cord-006860-a3b8hyyr	4330	30	CL	CL	NNP
cord-006860-a3b8hyyr	4330	31	in	in	IN
cord-006860-a3b8hyyr	4330	32	unstirred	unstirred	JJ
cord-006860-a3b8hyyr	4330	33	samples	sample	NNS
cord-006860-a3b8hyyr	4330	34	,	,	,
cord-006860-a3b8hyyr	4330	35	was	be	VBD
cord-006860-a3b8hyyr	4330	36	significantly	significantly	RB
cord-006860-a3b8hyyr	4330	37	enhanced	enhance	VBN
cord-006860-a3b8hyyr	4330	38	.	.	.
cord-006860-a3b8hyyr	4331	1	GR144053	GR144053	NNP
cord-006860-a3b8hyyr	4331	2	also	also	RB
cord-006860-a3b8hyyr	4331	3	reduced	reduce	VBN
cord-006860-a3b8hyyr	4331	4	adhesion	adhesion	NN
cord-006860-a3b8hyyr	4331	5	of	of	IN
cord-006860-a3b8hyyr	4331	6	platelets	platelet	NNS
cord-006860-a3b8hyyr	4331	7	to	to	IN
cord-006860-a3b8hyyr	4331	8	neutrophils	neutrophil	NNS
cord-006860-a3b8hyyr	4331	9	,	,	,
cord-006860-a3b8hyyr	4331	10	but	but	CC
cord-006860-a3b8hyyr	4331	11	did	do	VBD
cord-006860-a3b8hyyr	4331	12	not	not	RB
cord-006860-a3b8hyyr	4331	13	affect	affect	VB
cord-006860-a3b8hyyr	4331	14	CD62	cd62	JJ
cord-006860-a3b8hyyr	4331	15	exposure	exposure	NN
cord-006860-a3b8hyyr	4331	16	.	.	.
cord-006860-a3b8hyyr	4332	1	The	the	DT
cord-006860-a3b8hyyr	4332	2	results	result	NNS
cord-006860-a3b8hyyr	4332	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	4332	4	that	that	IN
cord-006860-a3b8hyyr	4332	5	interaction	interaction	NN
cord-006860-a3b8hyyr	4332	6	of	of	IN
cord-006860-a3b8hyyr	4332	7	platelets	platelet	NNS
cord-006860-a3b8hyyr	4332	8	with	with	IN
cord-006860-a3b8hyyr	4332	9	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	4332	10	*	*	NFP
cord-006860-a3b8hyyr	4332	11	in	in	IN
cord-006860-a3b8hyyr	4332	12	whole	whole	JJ
cord-006860-a3b8hyyr	4332	13	blood	blood	NN
cord-006860-a3b8hyyr	4332	14	via	via	IN
cord-006860-a3b8hyyr	4332	15	CD62	CD62	NNP
cord-006860-a3b8hyyr	4332	16	and	and	CC
cord-006860-a3b8hyyr	4332	17	Fg	Fg	NNP
cord-006860-a3b8hyyr	4332	18	may	may	MD
cord-006860-a3b8hyyr	4332	19	have	have	VB
cord-006860-a3b8hyyr	4332	20	opposite	opposite	JJ
cord-006860-a3b8hyyr	4332	21	effects	effect	NNS
cord-006860-a3b8hyyr	4332	22	on	on	IN
cord-006860-a3b8hyyr	4332	23	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	4332	24	ROS	ROS	NNP
cord-006860-a3b8hyyr	4332	25	production	production	NN
cord-006860-a3b8hyyr	4332	26	:	:	:
cord-006860-a3b8hyyr	4332	27	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4332	28	by	by	IN
cord-006860-a3b8hyyr	4332	29	CD62	CD62	NNP
cord-006860-a3b8hyyr	4332	30	and	and	CC
cord-006860-a3b8hyyr	4332	31	inhibition	inhibition	NN
cord-006860-a3b8hyyr	4332	32	by	by	IN
cord-006860-a3b8hyyr	4332	33	platelet	platelet	NN
cord-006860-a3b8hyyr	4332	34	-	-	HYPH
cord-006860-a3b8hyyr	4332	35	bound	bind	VBN
cord-006860-a3b8hyyr	4332	36	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4332	37	.	.	.
cord-006860-a3b8hyyr	4333	1	Late	late	JJ
cord-006860-a3b8hyyr	4333	2	reocclusive	reocclusive	JJ
cord-006860-a3b8hyyr	4333	3	processes	process	NNS
cord-006860-a3b8hyyr	4333	4	represent	represent	VBP
cord-006860-a3b8hyyr	4333	5	one	one	CD
cord-006860-a3b8hyyr	4333	6	of	of	IN
cord-006860-a3b8hyyr	4333	7	the	the	DT
cord-006860-a3b8hyyr	4333	8	most	most	RBS
cord-006860-a3b8hyyr	4333	9	commonly	commonly	RB
cord-006860-a3b8hyyr	4333	10	seen	see	VBN
cord-006860-a3b8hyyr	4333	11	serious	serious	JJ
cord-006860-a3b8hyyr	4333	12	adverse	adverse	JJ
cord-006860-a3b8hyyr	4333	13	events	event	NNS
cord-006860-a3b8hyyr	4333	14	after	after	IN
cord-006860-a3b8hyyr	4333	15	coronary	coronary	JJ
cord-006860-a3b8hyyr	4333	16	angioplasty	angioplasty	NN
cord-006860-a3b8hyyr	4333	17	.	.	.
cord-006860-a3b8hyyr	4334	1	The	the	DT
cord-006860-a3b8hyyr	4334	2	pathophysiology	pathophysiology	NN
cord-006860-a3b8hyyr	4334	3	of	of	IN
cord-006860-a3b8hyyr	4334	4	both	both	DT
cord-006860-a3b8hyyr	4334	5	of	of	IN
cord-006860-a3b8hyyr	4334	6	these	these	DT
cord-006860-a3b8hyyr	4334	7	processes	process	NNS
cord-006860-a3b8hyyr	4334	8	is	be	VBZ
cord-006860-a3b8hyyr	4334	9	multifunctional	multifunctional	JJ
cord-006860-a3b8hyyr	4334	10	and	and	CC
cord-006860-a3b8hyyr	4334	11	represens	represens	JJ
cord-006860-a3b8hyyr	4334	12	complex	complex	JJ
cord-006860-a3b8hyyr	4334	13	time	time	NN
cord-006860-a3b8hyyr	4334	14	dependent	dependent	JJ
cord-006860-a3b8hyyr	4334	15	pathophysiologic	pathophysiologic	JJ
cord-006860-a3b8hyyr	4334	16	events	event	NNS
cord-006860-a3b8hyyr	4334	17	involving	involve	VBG
cord-006860-a3b8hyyr	4334	18	both	both	CC
cord-006860-a3b8hyyr	4334	19	the	the	DT
cord-006860-a3b8hyyr	4334	20	humeral	humeral	JJ
cord-006860-a3b8hyyr	4334	21	and	and	CC
cord-006860-a3b8hyyr	4334	22	cellular	cellular	JJ
cord-006860-a3b8hyyr	4334	23	processes	process	NNS
cord-006860-a3b8hyyr	4334	24	.	.	.
cord-006860-a3b8hyyr	4335	1	To	to	TO
cord-006860-a3b8hyyr	4335	2	test	test	VB
cord-006860-a3b8hyyr	4335	3	the	the	DT
cord-006860-a3b8hyyr	4335	4	effects	effect	NNS
cord-006860-a3b8hyyr	4335	5	of	of	IN
cord-006860-a3b8hyyr	4335	6	low	low	JJ
cord-006860-a3b8hyyr	4335	7	molecular	molecular	JJ
cord-006860-a3b8hyyr	4335	8	weight	weight	NN
cord-006860-a3b8hyyr	4335	9	heparin	heparin	NNP
cord-006860-a3b8hyyr	4336	1	(	(	-LRB-
cord-006860-a3b8hyyr	4336	2	Certoparin	Certoparin	NNP
cord-006860-a3b8hyyr	4336	3	,	,	,
cord-006860-a3b8hyyr	4336	4	Sandoz	Sandoz	NNP
cord-006860-a3b8hyyr	4336	5	AG	AG	NNP
cord-006860-a3b8hyyr	4336	6	,	,	,
cord-006860-a3b8hyyr	4336	7	Numberg	Numberg	NNP
cord-006860-a3b8hyyr	4336	8	Germany	Germany	NNP
cord-006860-a3b8hyyr	4336	9	)	)	-RRB-
cord-006860-a3b8hyyr	4336	10	against	against	IN
cord-006860-a3b8hyyr	4336	11	late	late	JJ
cord-006860-a3b8hyyr	4336	12	occlusive	occlusive	JJ
cord-006860-a3b8hyyr	4336	13	processes	process	NNS
cord-006860-a3b8hyyr	4336	14	,	,	,
cord-006860-a3b8hyyr	4336	15	four	four	CD
cord-006860-a3b8hyyr	4336	16	groups	group	NNS
cord-006860-a3b8hyyr	4336	17	(	(	-LRB-
cord-006860-a3b8hyyr	4336	18	Groups	group	NNS
cord-006860-a3b8hyyr	4336	19	A	A	NNP
cord-006860-a3b8hyyr	4336	20	-	-	HYPH
cord-006860-a3b8hyyr	4336	21	D	d	NN
cord-006860-a3b8hyyr	4336	22	)	)	-RRB-
cord-006860-a3b8hyyr	4336	23	of	of	IN
cord-006860-a3b8hyyr	4336	24	rats	rat	NNS
cord-006860-a3b8hyyr	4336	25	(	(	-LRB-
cord-006860-a3b8hyyr	4336	26	7	7	CD
cord-006860-a3b8hyyr	4336	27	-	-	SYM
cord-006860-a3b8hyyr	4336	28	10	10	CD
cord-006860-a3b8hyyr	4336	29	)	)	-RRB-
cord-006860-a3b8hyyr	4336	30	were	be	VBD
cord-006860-a3b8hyyr	4336	31	anesthetized	anesthetize	VBN
cord-006860-a3b8hyyr	4336	32	and	and	CC
cord-006860-a3b8hyyr	4336	33	the	the	DT
cord-006860-a3b8hyyr	4336	34	external	external	JJ
cord-006860-a3b8hyyr	4336	35	common	common	JJ
cord-006860-a3b8hyyr	4336	36	carotid	carotid	JJ
cord-006860-a3b8hyyr	4336	37	arteries	artery	NNS
cord-006860-a3b8hyyr	4336	38	were	be	VBD
cord-006860-a3b8hyyr	4336	39	exposed	expose	VBN
cord-006860-a3b8hyyr	4336	40	.	.	.
cord-006860-a3b8hyyr	4337	1	All	all	DT
cord-006860-a3b8hyyr	4337	2	groups	group	NNS
cord-006860-a3b8hyyr	4337	3	received	receive	VBD
cord-006860-a3b8hyyr	4337	4	a	a	DT
cord-006860-a3b8hyyr	4337	5	200	200	CD
cord-006860-a3b8hyyr	4337	6	u	u	NN
cord-006860-a3b8hyyr	4337	7	/	/	SYM
cord-006860-a3b8hyyr	4337	8	kg	kg	NNS
cord-006860-a3b8hyyr	4337	9	of	of	IN
cord-006860-a3b8hyyr	4337	10	unfraetionated	unfraetionate	VBN
cord-006860-a3b8hyyr	4337	11	heparin	heparin	NN
cord-006860-a3b8hyyr	4337	12	through	through	IN
cord-006860-a3b8hyyr	4337	13	the	the	DT
cord-006860-a3b8hyyr	4337	14	femoral	femoral	JJ
cord-006860-a3b8hyyr	4337	15	vein	vein	NN
cord-006860-a3b8hyyr	4337	16	.	.	.
cord-006860-a3b8hyyr	4338	1	A	a	DT
cord-006860-a3b8hyyr	4338	2	2F	2f	CD
cord-006860-a3b8hyyr	4338	3	balloon	balloon	NN
cord-006860-a3b8hyyr	4338	4	emboleetomy	emboleetomy	NN
cord-006860-a3b8hyyr	4338	5	catheter	catheter	NN
cord-006860-a3b8hyyr	4338	6	was	be	VBD
cord-006860-a3b8hyyr	4338	7	inserted	insert	VBN
cord-006860-a3b8hyyr	4338	8	into	into	IN
cord-006860-a3b8hyyr	4338	9	the	the	DT
cord-006860-a3b8hyyr	4338	10	left	left	JJ
cord-006860-a3b8hyyr	4338	11	carotid	carotid	JJ
cord-006860-a3b8hyyr	4338	12	artery	artery	NN
cord-006860-a3b8hyyr	4338	13	and	and	CC
cord-006860-a3b8hyyr	4338	14	passed	pass	VBD
cord-006860-a3b8hyyr	4338	15	throug	throug	RP
cord-006860-a3b8hyyr	4338	16	the	the	DT
cord-006860-a3b8hyyr	4338	17	left	left	JJ
cord-006860-a3b8hyyr	4338	18	common	common	JJ
cord-006860-a3b8hyyr	4338	19	carotid	carotid	JJ
cord-006860-a3b8hyyr	4338	20	artery	artery	NN
cord-006860-a3b8hyyr	4338	21	leading	lead	VBG
cord-006860-a3b8hyyr	4338	22	to	to	IN
cord-006860-a3b8hyyr	4338	23	the	the	DT
cord-006860-a3b8hyyr	4338	24	aortic	aortic	JJ
cord-006860-a3b8hyyr	4338	25	arck	arck	NN
cord-006860-a3b8hyyr	4338	26	Vascdar	Vascdar	NNP
cord-006860-a3b8hyyr	4338	27	injury	injury	NN
cord-006860-a3b8hyyr	4338	28	was	be	VBD
cord-006860-a3b8hyyr	4338	29	induced	induce	VBN
cord-006860-a3b8hyyr	4338	30	by	by	IN
cord-006860-a3b8hyyr	4338	31	repeatedly	repeatedly	RB
cord-006860-a3b8hyyr	4338	32	(	(	-LRB-
cord-006860-a3b8hyyr	4338	33	x3	x3	NNP
cord-006860-a3b8hyyr	4338	34	)	)	-RRB-
cord-006860-a3b8hyyr	4338	35	inflating	inflate	VBG
cord-006860-a3b8hyyr	4338	36	the	the	DT
cord-006860-a3b8hyyr	4338	37	catheter	catheter	NN
cord-006860-a3b8hyyr	4338	38	balloon	balloon	NN
cord-006860-a3b8hyyr	4338	39	and	and	CC
cord-006860-a3b8hyyr	4338	40	withdrawing	withdraw	VBG
cord-006860-a3b8hyyr	4338	41	it	-PRON-	PRP
cord-006860-a3b8hyyr	4338	42	to	to	IN
cord-006860-a3b8hyyr	4338	43	the	the	DT
cord-006860-a3b8hyyr	4338	44	bifurcation	bifurcation	NN
cord-006860-a3b8hyyr	4338	45	.	.	.
cord-006860-a3b8hyyr	4339	1	Following	follow	VBG
cord-006860-a3b8hyyr	4339	2	this	this	DT
cord-006860-a3b8hyyr	4339	3	procedure	procedure	NN
cord-006860-a3b8hyyr	4339	4	,	,	,
cord-006860-a3b8hyyr	4339	5	two	two	CD
cord-006860-a3b8hyyr	4339	6	hours	hour	NNS
cord-006860-a3b8hyyr	4339	7	after	after	RB
cord-006860-a3b8hyyr	4339	8	,	,	,
cord-006860-a3b8hyyr	4339	9	equlgravimetric	equlgravimetric	JJ
cord-006860-a3b8hyyr	4339	10	amounts	amount	NNS
cord-006860-a3b8hyyr	4339	11	of	of	IN
cord-006860-a3b8hyyr	4339	12	various	various	JJ
cord-006860-a3b8hyyr	4339	13	agents	agent	NNS
cord-006860-a3b8hyyr	4339	14	were	be	VBD
cord-006860-a3b8hyyr	4339	15	administered	administer	VBN
cord-006860-a3b8hyyr	4339	16	via	via	IN
cord-006860-a3b8hyyr	4339	17	SC	SC	NNP
cord-006860-a3b8hyyr	4339	18	route	route	NN
cord-006860-a3b8hyyr	4339	19	to	to	IN
cord-006860-a3b8hyyr	4339	20	each	each	DT
cord-006860-a3b8hyyr	4339	21	of	of	IN
cord-006860-a3b8hyyr	4339	22	the	the	DT
cord-006860-a3b8hyyr	4339	23	individual	individual	JJ
cord-006860-a3b8hyyr	4339	24	groups	group	NNS
cord-006860-a3b8hyyr	4339	25	.	.	.
cord-006860-a3b8hyyr	4340	1	Group	Group	NNP
cord-006860-a3b8hyyr	4340	2	A	A	NNP
cord-006860-a3b8hyyr	4340	3	was	be	VBD
cord-006860-a3b8hyyr	4340	4	administered	administer	VBN
cord-006860-a3b8hyyr	4340	5	with	with	IN
cord-006860-a3b8hyyr	4340	6	Certoparin	Certoparin	NNP
cord-006860-a3b8hyyr	4340	7	OD	OD	NNP
cord-006860-a3b8hyyr	4340	8	for	for	IN
cord-006860-a3b8hyyr	4340	9	21	21	CD
cord-006860-a3b8hyyr	4340	10	days	day	NNS
cord-006860-a3b8hyyr	4340	11	.	.	.
cord-006860-a3b8hyyr	4341	1	Group	Group	NNP
cord-006860-a3b8hyyr	4341	2	B	B	NNP
cord-006860-a3b8hyyr	4341	3	received	receive	VBD
cord-006860-a3b8hyyr	4341	4	a	a	DT
cord-006860-a3b8hyyr	4341	5	lower	low	JJR
cord-006860-a3b8hyyr	4341	6	low	low	JJ
cord-006860-a3b8hyyr	4341	7	molecular	molecular	JJ
cord-006860-a3b8hyyr	4341	8	weight	weight	NN
cord-006860-a3b8hyyr	4341	9	heprin	heprin	NNP
cord-006860-a3b8hyyr	4341	10	(	(	-LRB-
cord-006860-a3b8hyyr	4341	11	Mr	Mr	NNP
cord-006860-a3b8hyyr	4341	12	3.4	3.4	CD
cord-006860-a3b8hyyr	4341	13	kDa	kDa	NNPS
cord-006860-a3b8hyyr	4341	14	)	)	-RRB-
cord-006860-a3b8hyyr	4341	15	.	.	.
cord-006860-a3b8hyyr	4342	1	Group	Group	NNP
cord-006860-a3b8hyyr	4342	2	C	C	NNP
cord-006860-a3b8hyyr	4342	3	received	receive	VBD
cord-006860-a3b8hyyr	4342	4	unfraetionated	unfraetionated	JJ
cord-006860-a3b8hyyr	4342	5	heparin	heparin	NN
cord-006860-a3b8hyyr	4342	6	and	and	CC
cord-006860-a3b8hyyr	4342	7	Group	Group	NNP
cord-006860-a3b8hyyr	4342	8	D	D	NNP
cord-006860-a3b8hyyr	4342	9	served	serve	VBD
cord-006860-a3b8hyyr	4342	10	as	as	IN
cord-006860-a3b8hyyr	4342	11	a	a	DT
cord-006860-a3b8hyyr	4342	12	control	control	NN
cord-006860-a3b8hyyr	4342	13	.	.	.
cord-006860-a3b8hyyr	4343	1	On	on	IN
cord-006860-a3b8hyyr	4343	2	day	day	NN
cord-006860-a3b8hyyr	4343	3	21	21	CD
cord-006860-a3b8hyyr	4343	4	,	,	,
cord-006860-a3b8hyyr	4343	5	perfusion	perfusion	NN
cord-006860-a3b8hyyr	4343	6	fixation	fixation	NN
cord-006860-a3b8hyyr	4343	7	was	be	VBD
cord-006860-a3b8hyyr	4343	8	performed	perform	VBN
cord-006860-a3b8hyyr	4343	9	on	on	IN
cord-006860-a3b8hyyr	4343	10	all	all	DT
cord-006860-a3b8hyyr	4343	11	animals	animal	NNS
cord-006860-a3b8hyyr	4343	12	.	.	.
cord-006860-a3b8hyyr	4344	1	The	the	DT
cord-006860-a3b8hyyr	4344	2	injured	injured	JJ
cord-006860-a3b8hyyr	4344	3	and	and	CC
cord-006860-a3b8hyyr	4344	4	contralateral	contralateral	JJ
cord-006860-a3b8hyyr	4344	5	carotid	carotid	JJ
cord-006860-a3b8hyyr	4344	6	arteries	artery	NNS
cord-006860-a3b8hyyr	4344	7	were	be	VBD
cord-006860-a3b8hyyr	4344	8	excised	excise	VBN
cord-006860-a3b8hyyr	4344	9	for	for	IN
cord-006860-a3b8hyyr	4344	10	histelogic	histelogic	NN
cord-006860-a3b8hyyr	4344	11	examinatior~	examinatior~	JJ
cord-006860-a3b8hyyr	4345	1	In	in	IN
cord-006860-a3b8hyyr	4345	2	comparison	comparison	NN
cord-006860-a3b8hyyr	4345	3	to	to	IN
cord-006860-a3b8hyyr	4345	4	the	the	DT
cord-006860-a3b8hyyr	4345	5	saline	saline	NN
cord-006860-a3b8hyyr	4345	6	control	control	NN
cord-006860-a3b8hyyr	4345	7	,	,	,
cord-006860-a3b8hyyr	4345	8	varying	vary	VBG
cord-006860-a3b8hyyr	4345	9	degrees	degree	NNS
cord-006860-a3b8hyyr	4345	10	of	of	IN
cord-006860-a3b8hyyr	4345	11	the	the	DT
cord-006860-a3b8hyyr	4345	12	inhibition	inhibition	NN
cord-006860-a3b8hyyr	4345	13	of	of	IN
cord-006860-a3b8hyyr	4345	14	myointimal	myointimal	JJ
cord-006860-a3b8hyyr	4345	15	proliferation	proliferation	NN
cord-006860-a3b8hyyr	4345	16	following	follow	VBG
cord-006860-a3b8hyyr	4345	17	arterial	arterial	JJ
cord-006860-a3b8hyyr	4345	18	injury	injury	NN
cord-006860-a3b8hyyr	4345	19	was	be	VBD
cord-006860-a3b8hyyr	4345	20	noted	note	VBN
cord-006860-a3b8hyyr	4345	21	in	in	IN
cord-006860-a3b8hyyr	4345	22	all	all	DT
cord-006860-a3b8hyyr	4345	23	groups	group	NNS
cord-006860-a3b8hyyr	4345	24	.	.	.
cord-006860-a3b8hyyr	4346	1	However	however	RB
cord-006860-a3b8hyyr	4346	2	,	,	,
cord-006860-a3b8hyyr	4346	3	the	the	DT
cord-006860-a3b8hyyr	4346	4	degree	degree	NN
cord-006860-a3b8hyyr	4346	5	of	of	IN
cord-006860-a3b8hyyr	4346	6	inhibition	inhibition	NN
cord-006860-a3b8hyyr	4346	7	followed	follow	VBD
cord-006860-a3b8hyyr	4346	8	the	the	DT
cord-006860-a3b8hyyr	4346	9	order	order	NN
cord-006860-a3b8hyyr	4346	10	:	:	:
cord-006860-a3b8hyyr	4346	11	heparin	heparin	JJ
cord-006860-a3b8hyyr	4346	12	<	<	XX
cord-006860-a3b8hyyr	4346	13	Certopann	Certopann	NNP
cord-006860-a3b8hyyr	4346	14	<	<	XX
cord-006860-a3b8hyyr	4346	15	LLMWH	LLMWH	NNP
cord-006860-a3b8hyyr	4346	16	_	_	NNP
cord-006860-a3b8hyyr	4347	1	In	in	IN
cord-006860-a3b8hyyr	4347	2	contrast	contrast	NN
cord-006860-a3b8hyyr	4347	3	to	to	IN
cord-006860-a3b8hyyr	4347	4	heparin	heparin	NN
cord-006860-a3b8hyyr	4347	5	treated	treat	VBN
cord-006860-a3b8hyyr	4347	6	group	group	NN
cord-006860-a3b8hyyr	4347	7	(	(	-LRB-
cord-006860-a3b8hyyr	4347	8	C	C	NNP
cord-006860-a3b8hyyr	4347	9	)	)	-RRB-
cord-006860-a3b8hyyr	4347	10	,	,	,
cord-006860-a3b8hyyr	4347	11	the	the	DT
cord-006860-a3b8hyyr	4347	12	other	other	JJ
cord-006860-a3b8hyyr	4347	13	groups	group	NNS
cord-006860-a3b8hyyr	4347	14	A	A	NNP
cord-006860-a3b8hyyr	4347	15	,	,	,
cord-006860-a3b8hyyr	4347	16	B	b	NN
cord-006860-a3b8hyyr	4347	17	,	,	,
cord-006860-a3b8hyyr	4347	18	and	and	CC
cord-006860-a3b8hyyr	4347	19	D	D	NNP
cord-006860-a3b8hyyr	4347	20	did	do	VBD
cord-006860-a3b8hyyr	4347	21	not	not	RB
cord-006860-a3b8hyyr	4347	22	exhibit	exhibit	VB
cord-006860-a3b8hyyr	4347	23	any	any	DT
cord-006860-a3b8hyyr	4347	24	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	4347	25	lesions	lesion	NNS
cord-006860-a3b8hyyr	4347	26	.	.	.
cord-006860-a3b8hyyr	4348	1	However	however	RB
cord-006860-a3b8hyyr	4348	2	,	,	,
cord-006860-a3b8hyyr	4348	3	degree	degree	NN
cord-006860-a3b8hyyr	4348	4	of	of	IN
cord-006860-a3b8hyyr	4348	5	perivascular	perivascular	JJ
cord-006860-a3b8hyyr	4348	6	fibrosis	fibrosis	NN
cord-006860-a3b8hyyr	4348	7	,	,	,
cord-006860-a3b8hyyr	4348	8	hemorrhage	hemorrhage	NN
cord-006860-a3b8hyyr	4348	9	and	and	CC
cord-006860-a3b8hyyr	4348	10	inflammation	inflammation	NN
cord-006860-a3b8hyyr	4348	11	were	be	VBD
cord-006860-a3b8hyyr	4348	12	observed	observe	VBN
cord-006860-a3b8hyyr	4348	13	at	at	IN
cord-006860-a3b8hyyr	4348	14	the	the	DT
cord-006860-a3b8hyyr	4348	15	infusion	infusion	NN
cord-006860-a3b8hyyr	4348	16	site	site	NN
cord-006860-a3b8hyyr	4348	17	.	.	.
cord-006860-a3b8hyyr	4349	1	In	in	IN
cord-006860-a3b8hyyr	4349	2	comparison	comparison	NN
cord-006860-a3b8hyyr	4349	3	to	to	IN
cord-006860-a3b8hyyr	4349	4	heparin	heparin	NN
cord-006860-a3b8hyyr	4349	5	,	,	,
cord-006860-a3b8hyyr	4349	6	Certoparin	Certoparin	NNP
cord-006860-a3b8hyyr	4349	7	and	and	CC
cord-006860-a3b8hyyr	4349	8	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4349	9	lower	low	JJR
cord-006860-a3b8hyyr	4349	10	low	low	JJ
cord-006860-a3b8hyyr	4349	11	molecular	molecular	JJ
cord-006860-a3b8hyyr	4349	12	weight	weight	NN
cord-006860-a3b8hyyr	4349	13	derivatives	derivative	NNS
cord-006860-a3b8hyyr	4349	14	exhibit	exhibit	VBP
cord-006860-a3b8hyyr	4349	15	better	well	JJR
cord-006860-a3b8hyyr	4349	16	efficacy	efficacy	NN
cord-006860-a3b8hyyr	4349	17	in	in	IN
cord-006860-a3b8hyyr	4349	18	reducing	reduce	VBG
cord-006860-a3b8hyyr	4349	19	balloon	balloon	NN
cord-006860-a3b8hyyr	4349	20	angioplasty	angioplasty	NN
cord-006860-a3b8hyyr	4349	21	induced	induce	VBN
cord-006860-a3b8hyyr	4349	22	restenosis	restenosis	NNP
cord-006860-a3b8hyyr	4349	23	.	.	.
cord-006860-a3b8hyyr	4350	1	The	the	DT
cord-006860-a3b8hyyr	4350	2	observed	observed	JJ
cord-006860-a3b8hyyr	4350	3	efficacy	efficacy	NN
cord-006860-a3b8hyyr	4350	4	of	of	IN
cord-006860-a3b8hyyr	4350	5	these	these	DT
cord-006860-a3b8hyyr	4350	6	agents	agent	NNS
cord-006860-a3b8hyyr	4350	7	may	may	MD
cord-006860-a3b8hyyr	4350	8	be	be	VB
cord-006860-a3b8hyyr	4350	9	due	due	JJ
cord-006860-a3b8hyyr	4350	10	to	to	IN
cord-006860-a3b8hyyr	4350	11	better	well	JJR
cord-006860-a3b8hyyr	4350	12	bioavailability	bioavailability	NN
cord-006860-a3b8hyyr	4350	13	and	and	CC
cord-006860-a3b8hyyr	4350	14	sustained	sustained	JJ
cord-006860-a3b8hyyr	4350	15	duration	duration	NN
cord-006860-a3b8hyyr	4350	16	of	of	IN
cord-006860-a3b8hyyr	4350	17	action	action	NN
cord-006860-a3b8hyyr	4350	18	.	.	.
cord-006860-a3b8hyyr	4351	1	In	in	IN
cord-006860-a3b8hyyr	4351	2	the	the	DT
cord-006860-a3b8hyyr	4351	3	present	present	JJ
cord-006860-a3b8hyyr	4351	4	paper	paper	NN
cord-006860-a3b8hyyr	4351	5	the	the	DT
cord-006860-a3b8hyyr	4351	6	binding	binding	NN
cord-006860-a3b8hyyr	4351	7	of	of	IN
cord-006860-a3b8hyyr	4351	8	heparin	heparin	NN
cord-006860-a3b8hyyr	4351	9	to	to	IN
cord-006860-a3b8hyyr	4351	10	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4351	11	of	of	IN
cord-006860-a3b8hyyr	4351	12	human	human	NN
cord-006860-a3b8hyyr	4351	13	and	and	CC
cord-006860-a3b8hyyr	4351	14	animal	animal	NN
cord-006860-a3b8hyyr	4351	15	species	specie	NNS
cord-006860-a3b8hyyr	4351	16	was	be	VBD
cord-006860-a3b8hyyr	4351	17	analyzed	analyze	VBN
cord-006860-a3b8hyyr	4351	18	and	and	CC
cord-006860-a3b8hyyr	4351	19	compared	compare	VBN
cord-006860-a3b8hyyr	4351	20	with	with	IN
cord-006860-a3b8hyyr	4351	21	the	the	DT
cord-006860-a3b8hyyr	4351	22	binding	binding	NN
cord-006860-a3b8hyyr	4351	23	to	to	IN
cord-006860-a3b8hyyr	4351	24	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	4351	25	and	and	CC
cord-006860-a3b8hyyr	4351	26	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	4351	27	.	.	.
cord-006860-a3b8hyyr	4352	1	A	a	DT
cord-006860-a3b8hyyr	4352	2	low	low	JJ
cord-006860-a3b8hyyr	4352	3	-	-	HYPH
cord-006860-a3b8hyyr	4352	4	molecularmass	molecularmass	NN
cord-006860-a3b8hyyr	4352	5	heparin	heparin	NN
cord-006860-a3b8hyyr	4352	6	(	(	-LRB-
cord-006860-a3b8hyyr	4352	7	LMMH	LMMH	NNP
cord-006860-a3b8hyyr	4352	8	)	)	-RRB-
cord-006860-a3b8hyyr	4352	9	was	be	VBD
cord-006860-a3b8hyyr	4352	10	covalently	covalently	RB
cord-006860-a3b8hyyr	4352	11	bound	bind	VBN
cord-006860-a3b8hyyr	4352	12	to	to	IN
cord-006860-a3b8hyyr	4352	13	tyramine	tyramine	NN
cord-006860-a3b8hyyr	4352	14	(	(	-LRB-
cord-006860-a3b8hyyr	4352	15	tyr	tyr	NNP
cord-006860-a3b8hyyr	4352	16	)	)	-RRB-
cord-006860-a3b8hyyr	4352	17	and	and	CC
cord-006860-a3b8hyyr	4352	18	subsequently	subsequently	RB
cord-006860-a3b8hyyr	4352	19	tagged	tag	VBD
cord-006860-a3b8hyyr	4352	20	with	with	IN
cord-006860-a3b8hyyr	4352	21	fluorescein-5-isothiocyanate	fluorescein-5-isothiocyanate	NNP
cord-006860-a3b8hyyr	4352	22	(	(	-LRB-
cord-006860-a3b8hyyr	4352	23	fitc	fitc	NN
cord-006860-a3b8hyyr	4352	24	)	)	-RRB-
cord-006860-a3b8hyyr	4352	25	by	by	IN
cord-006860-a3b8hyyr	4352	26	endpoint	endpoint	NN
cord-006860-a3b8hyyr	4352	27	attachmenC.	attachmenc.	NN
cord-006860-a3b8hyyr	4352	28	Binding	bind	VBG
cord-006860-a3b8hyyr	4352	29	to	to	IN
cord-006860-a3b8hyyr	4352	30	leukocytes	leukocyte	NNS
cord-006860-a3b8hyyr	4352	31	was	be	VBD
cord-006860-a3b8hyyr	4352	32	quantified	quantify	VBN
cord-006860-a3b8hyyr	4352	33	using	use	VBG
cord-006860-a3b8hyyr	4352	34	flow	flow	NN
cord-006860-a3b8hyyr	4352	35	cytometry	cytometry	NN
cord-006860-a3b8hyyr	4352	36	analysis	analysis	NN
cord-006860-a3b8hyyr	4352	37	.	.	.
cord-006860-a3b8hyyr	4353	1	The	the	DT
cord-006860-a3b8hyyr	4353	2	leukocyte	leukocyte	NN
cord-006860-a3b8hyyr	4353	3	populations	population	NNS
cord-006860-a3b8hyyr	4353	4	were	be	VBD
cord-006860-a3b8hyyr	4353	5	identified	identify	VBN
cord-006860-a3b8hyyr	4353	6	by	by	IN
cord-006860-a3b8hyyr	4353	7	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4353	8	light	light	JJ
cord-006860-a3b8hyyr	4353	9	scatter	scatter	NN
cord-006860-a3b8hyyr	4353	10	properties	property	NNS
cord-006860-a3b8hyyr	4353	11	in	in	IN
cord-006860-a3b8hyyr	4353	12	man	man	NN
cord-006860-a3b8hyyr	4353	13	by	by	IN
cord-006860-a3b8hyyr	4353	14	CD4	CD4	NNP
cord-006860-a3b8hyyr	4353	15	,	,	,
cord-006860-a3b8hyyr	4353	16	CD13	CD13	NNP
cord-006860-a3b8hyyr	4353	17	,	,	,
cord-006860-a3b8hyyr	4353	18	and	and	CC
cord-006860-a3b8hyyr	4353	19	CD14	CD14	NNP
cord-006860-a3b8hyyr	4353	20	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4353	21	,	,	,
cord-006860-a3b8hyyr	4353	22	in	in	IN
cord-006860-a3b8hyyr	4353	23	mice	mouse	NNS
cord-006860-a3b8hyyr	4353	24	by	by	IN
cord-006860-a3b8hyyr	4353	25	CD	CD	NNP
cord-006860-a3b8hyyr	4353	26	4	4	CD
cord-006860-a3b8hyyr	4353	27	and	and	CC
cord-006860-a3b8hyyr	4353	28	GR	GR	NNP
cord-006860-a3b8hyyr	4353	29	1	1	CD
cord-006860-a3b8hyyr	4353	30	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4353	31	,	,	,
cord-006860-a3b8hyyr	4353	32	and	and	CC
cord-006860-a3b8hyyr	4353	33	in	in	IN
cord-006860-a3b8hyyr	4353	34	rat	rat	NN
cord-006860-a3b8hyyr	4353	35	by	by	IN
cord-006860-a3b8hyyr	4353	36	CD	CD	NNP
cord-006860-a3b8hyyr	4353	37	45	45	CD
cord-006860-a3b8hyyr	4353	38	,	,	,
cord-006860-a3b8hyyr	4353	39	ED	ED	NNP
cord-006860-a3b8hyyr	4353	40	9	9	CD
cord-006860-a3b8hyyr	4353	41	,	,	,
cord-006860-a3b8hyyr	4353	42	and	and	CC
cord-006860-a3b8hyyr	4353	43	RP	RP	NNP
cord-006860-a3b8hyyr	4353	44	3	3	CD
cord-006860-a3b8hyyr	4353	45	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4353	46	.	.	.
cord-006860-a3b8hyyr	4354	1	Granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4354	2	,	,	,
cord-006860-a3b8hyyr	4354	3	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	4354	4	and	and	CC
cord-006860-a3b8hyyr	4354	5	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	4354	6	of	of	IN
cord-006860-a3b8hyyr	4354	7	all	all	DT
cord-006860-a3b8hyyr	4354	8	species	specie	NNS
cord-006860-a3b8hyyr	4354	9	bound	bind	VBN
cord-006860-a3b8hyyr	4354	10	dose	dose	NN
cord-006860-a3b8hyyr	4354	11	-	-	HYPH
cord-006860-a3b8hyyr	4354	12	dependently	dependently	RB
cord-006860-a3b8hyyr	4354	13	LMM	lmm	NN
cord-006860-a3b8hyyr	4354	14	-	-	HYPH
cord-006860-a3b8hyyr	4354	15	heparin	heparin	JJ
cord-006860-a3b8hyyr	4354	16	.	.	.
cord-006860-a3b8hyyr	4355	1	The	the	DT
cord-006860-a3b8hyyr	4355	2	binding	binding	NN
cord-006860-a3b8hyyr	4355	3	of	of	IN
cord-006860-a3b8hyyr	4355	4	LMMH	LMMH	NNP
cord-006860-a3b8hyyr	4355	5	-	-	HYPH
cord-006860-a3b8hyyr	4355	6	tyr	tyr	NNP
cord-006860-a3b8hyyr	4355	7	-	-	HYPH
cord-006860-a3b8hyyr	4355	8	fitc	fitc	NNP
cord-006860-a3b8hyyr	4356	1	~to	~to	NNP
cord-006860-a3b8hyyr	4357	1	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4357	2	was	be	VBD
cord-006860-a3b8hyyr	4357	3	higher	high	JJR
cord-006860-a3b8hyyr	4357	4	in	in	IN
cord-006860-a3b8hyyr	4357	5	human	human	NN
cord-006860-a3b8hyyr	4357	6	,	,	,
cord-006860-a3b8hyyr	4357	7	rat	rat	NN
cord-006860-a3b8hyyr	4357	8	,	,	,
cord-006860-a3b8hyyr	4357	9	rabbit	rabbit	NN
cord-006860-a3b8hyyr	4357	10	,	,	,
cord-006860-a3b8hyyr	4357	11	dog	dog	NN
cord-006860-a3b8hyyr	4357	12	,	,	,
cord-006860-a3b8hyyr	4357	13	and	and	CC
cord-006860-a3b8hyyr	4357	14	pig	pig	NN
cord-006860-a3b8hyyr	4357	15	as	as	IN
cord-006860-a3b8hyyr	4357	16	compared	compare	VBN
cord-006860-a3b8hyyr	4357	17	to	to	IN
cord-006860-a3b8hyyr	4357	18	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	4357	19	and	and	CC
cord-006860-a3b8hyyr	4357	20	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	4357	21	.	.	.
cord-006860-a3b8hyyr	4358	1	Mouse	mouse	NN
cord-006860-a3b8hyyr	4358	2	and	and	CC
cord-006860-a3b8hyyr	4358	3	sheep	sheep	NN
cord-006860-a3b8hyyr	4358	4	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4358	5	did	do	VBD
cord-006860-a3b8hyyr	4358	6	not	not	RB
cord-006860-a3b8hyyr	4358	7	bind	bind	VB
cord-006860-a3b8hyyr	4358	8	more	more	JJR
cord-006860-a3b8hyyr	4358	9	heparin	heparin	JJ
cord-006860-a3b8hyyr	4358	10	than	than	IN
cord-006860-a3b8hyyr	4358	11	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	4358	12	or	or	CC
cord-006860-a3b8hyyr	4358	13	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	4358	14	.	.	.
cord-006860-a3b8hyyr	4359	1	Binding	bind	VBG
cord-006860-a3b8hyyr	4359	2	of	of	IN
cord-006860-a3b8hyyr	4359	3	LMMH	LMMH	NNP
cord-006860-a3b8hyyr	4359	4	-	-	HYPH
cord-006860-a3b8hyyr	4359	5	tyr	tyr	NNP
cord-006860-a3b8hyyr	4359	6	-	-	HYPH
cord-006860-a3b8hyyr	4359	7	fitc	fitc	NN
cord-006860-a3b8hyyr	4359	8	was	be	VBD
cord-006860-a3b8hyyr	4359	9	reversible	reversible	JJ
cord-006860-a3b8hyyr	4359	10	in	in	IN
cord-006860-a3b8hyyr	4359	11	the	the	DT
cord-006860-a3b8hyyr	4359	12	presence	presence	NN
cord-006860-a3b8hyyr	4359	13	of	of	IN
cord-006860-a3b8hyyr	4359	14	unlabeled	unlabeled	JJ
cord-006860-a3b8hyyr	4359	15	heparin	heparin	NN
cord-006860-a3b8hyyr	4359	16	or	or	CC
cord-006860-a3b8hyyr	4359	17	LMMH	LMMH	NNP
cord-006860-a3b8hyyr	4359	18	.	.	.
cord-006860-a3b8hyyr	4360	1	More	More	JJR
cord-006860-a3b8hyyr	4360	2	than	than	IN
cord-006860-a3b8hyyr	4360	3	99	99	CD
cord-006860-a3b8hyyr	4360	4	%	%	NN
cord-006860-a3b8hyyr	4360	5	of	of	IN
cord-006860-a3b8hyyr	4360	6	human	human	NN
cord-006860-a3b8hyyr	4360	7	,	,	,
cord-006860-a3b8hyyr	4360	8	rat	rat	NN
cord-006860-a3b8hyyr	4360	9	,	,	,
cord-006860-a3b8hyyr	4360	10	rabbit	rabbit	NN
cord-006860-a3b8hyyr	4360	11	,	,	,
cord-006860-a3b8hyyr	4360	12	dog	dog	NN
cord-006860-a3b8hyyr	4360	13	and	and	CC
cord-006860-a3b8hyyr	4360	14	sheep	sheep	NN
cord-006860-a3b8hyyr	4360	15	granulocyte	granulocyte	NN
cord-006860-a3b8hyyr	4360	16	populations	population	NNS
cord-006860-a3b8hyyr	4360	17	could	could	MD
cord-006860-a3b8hyyr	4360	18	be'distinguished	be'distinguished	VB
cord-006860-a3b8hyyr	4360	19	from	from	IN
cord-006860-a3b8hyyr	4360	20	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	4360	21	and	and	CC
cord-006860-a3b8hyyr	4360	22	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	4360	23	by	by	IN
cord-006860-a3b8hyyr	4360	24	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4360	25	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	4360	26	intensity	intensity	NN
cord-006860-a3b8hyyr	4360	27	after	after	IN
cord-006860-a3b8hyyr	4360	28	incubation	incubation	NN
cord-006860-a3b8hyyr	4360	29	with	with	IN
cord-006860-a3b8hyyr	4360	30	LMMH	LMMH	NNP
cord-006860-a3b8hyyr	4360	31	-	-	HYPH
cord-006860-a3b8hyyr	4360	32	tyr	tyr	NNP
cord-006860-a3b8hyyr	4360	33	-	-	HYPH
cord-006860-a3b8hyyr	4360	34	fitc	fitc	NN
cord-006860-a3b8hyyr	4360	35	.	.	.
cord-006860-a3b8hyyr	4361	1	This	this	DT
cord-006860-a3b8hyyr	4361	2	separation	separation	NN
cord-006860-a3b8hyyr	4361	3	was	be	VBD
cord-006860-a3b8hyyr	4361	4	not	not	RB
cord-006860-a3b8hyyr	4361	5	obtained	obtain	VBN
cord-006860-a3b8hyyr	4361	6	for	for	IN
cord-006860-a3b8hyyr	4361	7	mouse	mouse	NN
cord-006860-a3b8hyyr	4361	8	and	and	CC
cord-006860-a3b8hyyr	4361	9	pig	pig	NN
cord-006860-a3b8hyyr	4361	10	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4361	11	.	.	.
cord-006860-a3b8hyyr	4362	1	The	the	DT
cord-006860-a3b8hyyr	4362	2	data	data	NN
cord-006860-a3b8hyyr	4362	3	present	present	VBP
cord-006860-a3b8hyyr	4362	4	evidence	evidence	NN
cord-006860-a3b8hyyr	4362	5	of	of	IN
cord-006860-a3b8hyyr	4362	6	a	a	DT
cord-006860-a3b8hyyr	4362	7	specific	specific	JJ
cord-006860-a3b8hyyr	4362	8	heparin	heparin	NN
cord-006860-a3b8hyyr	4362	9	binding	bind	VBG
cord-006860-a3b8hyyr	4362	10	to	to	IN
cord-006860-a3b8hyyr	4362	11	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4362	12	of	of	IN
cord-006860-a3b8hyyr	4362	13	many	many	JJ
cord-006860-a3b8hyyr	4362	14	species	specie	NNS
cord-006860-a3b8hyyr	4362	15	and	and	CC
cord-006860-a3b8hyyr	4362	16	indicate	indicate	VBP
cord-006860-a3b8hyyr	4362	17	the	the	DT
cord-006860-a3b8hyyr	4362	18	significance	significance	NN
cord-006860-a3b8hyyr	4362	19	of	of	IN
cord-006860-a3b8hyyr	4362	20	fluorescent	fluorescent	NN
cord-006860-a3b8hyyr	4362	21	labeled	label	VBN
cord-006860-a3b8hyyr	4362	22	LMM	lmm	NN
cord-006860-a3b8hyyr	4362	23	-	-	HYPH
cord-006860-a3b8hyyr	4362	24	heparin	heparin	JJ
cord-006860-a3b8hyyr	4362	25	for	for	IN
cord-006860-a3b8hyyr	4362	26	biological	biological	JJ
cord-006860-a3b8hyyr	4362	27	investigations	investigation	NNS
cord-006860-a3b8hyyr	4362	28	.	.	.
cord-006860-a3b8hyyr	4363	1	BACKGROUND	background	NN
cord-006860-a3b8hyyr	4363	2	AND	and	CC
cord-006860-a3b8hyyr	4363	3	PURPOSE	purpose	NN
cord-006860-a3b8hyyr	4363	4	:	:	:
cord-006860-a3b8hyyr	4363	5	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	4363	6	is	be	VBZ
cord-006860-a3b8hyyr	4363	7	an	an	DT
cord-006860-a3b8hyyr	4363	8	effective	effective	JJ
cord-006860-a3b8hyyr	4363	9	treatment	treatment	NN
cord-006860-a3b8hyyr	4363	10	for	for	IN
cord-006860-a3b8hyyr	4363	11	restoring	restore	VBG
cord-006860-a3b8hyyr	4363	12	coronary	coronary	JJ
cord-006860-a3b8hyyr	4363	13	artery	artery	NN
cord-006860-a3b8hyyr	4363	14	pat	pat	NNP
cord-006860-a3b8hyyr	4363	15	~	~	NNP
cord-006860-a3b8hyyr	4363	16	cy	cy	NNP
cord-006860-a3b8hyyr	4363	17	;	;	:
cord-006860-a3b8hyyr	4363	18	however	however	RB
cord-006860-a3b8hyyr	4363	19	,	,	,
cord-006860-a3b8hyyr	4363	20	acute	acute	JJ
cord-006860-a3b8hyyr	4363	21	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	4363	22	rencclusion	rencclusion	NN
cord-006860-a3b8hyyr	4363	23	is	be	VBZ
cord-006860-a3b8hyyr	4363	24	a	a	DT
cord-006860-a3b8hyyr	4363	25	drawback	drawback	NN
cord-006860-a3b8hyyr	4363	26	of	of	IN
cord-006860-a3b8hyyr	4363	27	the	the	DT
cord-006860-a3b8hyyr	4363	28	procedure	procedure	NN
cord-006860-a3b8hyyr	4363	29	.	.	.
cord-006860-a3b8hyyr	4364	1	Currem	currem	JJ
cord-006860-a3b8hyyr	4364	2	prevention	prevention	NN
cord-006860-a3b8hyyr	4364	3	of	of	IN
cord-006860-a3b8hyyr	4364	4	rencclusion	rencclusion	NN
cord-006860-a3b8hyyr	4364	5	relies	rely	VBZ
cord-006860-a3b8hyyr	4364	6	on	on	IN
cord-006860-a3b8hyyr	4364	7	antiplatelet	antiplatelet	JJ
cord-006860-a3b8hyyr	4364	8	agmts	agmts	NN
cord-006860-a3b8hyyr	4364	9	(	(	-LRB-
cord-006860-a3b8hyyr	4364	10	aspirin	aspirin	NN
cord-006860-a3b8hyyr	4364	11	)	)	-RRB-
cord-006860-a3b8hyyr	4364	12	and	and	CC
cord-006860-a3b8hyyr	4364	13	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	4364	14	agents	agent	NNS
cord-006860-a3b8hyyr	4364	15	0aeparin	0aeparin	CD
cord-006860-a3b8hyyr	4364	16	)	)	-RRB-
cord-006860-a3b8hyyr	4364	17	.	.	.
cord-006860-a3b8hyyr	4365	1	In	in	IN
cord-006860-a3b8hyyr	4365	2	the	the	DT
cord-006860-a3b8hyyr	4365	3	present	present	JJ
cord-006860-a3b8hyyr	4365	4	study	study	NN
cord-006860-a3b8hyyr	4365	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	4365	6	examined	examine	VBD
cord-006860-a3b8hyyr	4365	7	the	the	DT
cord-006860-a3b8hyyr	4365	8	time	time	NN
cord-006860-a3b8hyyr	4365	9	course	course	NN
cord-006860-a3b8hyyr	4365	10	of	of	IN
cord-006860-a3b8hyyr	4365	11	changes	change	NNS
cord-006860-a3b8hyyr	4365	12	in	in	IN
cord-006860-a3b8hyyr	4365	13	blood	blood	NN
cord-006860-a3b8hyyr	4365	14	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4365	15	and	and	CC
cord-006860-a3b8hyyr	4365	16	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4365	17	function	function	NN
cord-006860-a3b8hyyr	4365	18	following	follow	VBG
cord-006860-a3b8hyyr	4365	19	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	4365	20	in	in	IN
cord-006860-a3b8hyyr	4365	21	patients	patient	NNS
cord-006860-a3b8hyyr	4365	22	with	with	IN
cord-006860-a3b8hyyr	4365	23	ischaemic	ischaemic	JJ
cord-006860-a3b8hyyr	4365	24	heart	heart	NN
cord-006860-a3b8hyyr	4365	25	disease	disease	NN
cord-006860-a3b8hyyr	4365	26	.	.	.
cord-006860-a3b8hyyr	4366	1	20	20	CD
cord-006860-a3b8hyyr	4366	2	patients	patient	NNS
cord-006860-a3b8hyyr	4366	3	were	be	VBD
cord-006860-a3b8hyyr	4366	4	randomly	randomly	RB
cord-006860-a3b8hyyr	4366	5	assigned	assign	VBN
cord-006860-a3b8hyyr	4366	6	to	to	TO
cord-006860-a3b8hyyr	4366	7	receive	receive	VB
cord-006860-a3b8hyyr	4366	8	either	either	DT
cord-006860-a3b8hyyr	4366	9	standard	standard	JJ
cord-006860-a3b8hyyr	4366	10	therapy	therapy	NN
cord-006860-a3b8hyyr	4366	11	(	(	-LRB-
cord-006860-a3b8hyyr	4366	12	250	250	CD
cord-006860-a3b8hyyr	4366	13	nag	nag	NN
cord-006860-a3b8hyyr	4366	14	aspirin	aspirin	NN
cord-006860-a3b8hyyr	4366	15	p.o	p.o	NNP
cord-006860-a3b8hyyr	4366	16	.	.	NNP
cord-006860-a3b8hyyr	4366	17	;	;	:
cord-006860-a3b8hyyr	4366	18	5.000	5.000	CD
cord-006860-a3b8hyyr	4366	19	IU	IU	NNP
cord-006860-a3b8hyyr	4366	20	hepafin	hepafin	NN
cord-006860-a3b8hyyr	4366	21	i.e.	i.e.	FW
cord-006860-a3b8hyyr	4366	22	bolus	bolus	NN
cord-006860-a3b8hyyr	4366	23	,	,	,
cord-006860-a3b8hyyr	4366	24	and	and	CC
cord-006860-a3b8hyyr	4366	25	5	5	CD
cord-006860-a3b8hyyr	4366	26	-	-	SYM
cord-006860-a3b8hyyr	4366	27	10.000	10.000	CD
cord-006860-a3b8hyyr	4366	28	IU	IU	NNP
cord-006860-a3b8hyyr	4366	29	heparin	heparin	JJ
cord-006860-a3b8hyyr	4366	30	intra	intra	JJ
cord-006860-a3b8hyyr	4366	31	-	-	NN
cord-006860-a3b8hyyr	4366	32	proeadurally)(n=10	proeadurally)(n=10	JJ
cord-006860-a3b8hyyr	4366	33	)	)	-RRB-
cord-006860-a3b8hyyr	4366	34	,	,	,
cord-006860-a3b8hyyr	4366	35	or	or	CC
cord-006860-a3b8hyyr	4366	36	adjunctive	adjunctive	JJ
cord-006860-a3b8hyyr	4366	37	therapy	therapy	NN
cord-006860-a3b8hyyr	4366	38	(	(	-LRB-
cord-006860-a3b8hyyr	4366	39	aspirin	aspirin	NN
cord-006860-a3b8hyyr	4366	40	,	,	,
cord-006860-a3b8hyyr	4366	41	hepann	hepann	NNP
cord-006860-a3b8hyyr	4366	42	;	;	:
cord-006860-a3b8hyyr	4366	43	100	100	CD
cord-006860-a3b8hyyr	4366	44	mg	mg	NNP
cord-006860-a3b8hyyr	4366	45	sodium	sodium	NN
cord-006860-a3b8hyyr	4366	46	pmtosan	pmtosan	NNP
cord-006860-a3b8hyyr	4366	47	polysulphate	polysulphate	NNP
cord-006860-a3b8hyyr	4366	48	,	,	,
cord-006860-a3b8hyyr	4366	49	SPP	SPP	NNP
cord-006860-a3b8hyyr	4366	50	intra	intra	NNP
cord-006860-a3b8hyyr	4366	51	-	-	JJ
cord-006860-a3b8hyyr	4366	52	cortmarily	cortmarily	JJ
cord-006860-a3b8hyyr	4366	53	and	and	CC
cord-006860-a3b8hyyr	4366	54	subcutaneously	subcutaneously	RB
cord-006860-a3b8hyyr	4366	55	)	)	-RRB-
cord-006860-a3b8hyyr	4366	56	(	(	-LRB-
cord-006860-a3b8hyyr	4366	57	n=10	n=10	NNP
cord-006860-a3b8hyyr	4366	58	)	)	-RRB-
cord-006860-a3b8hyyr	4366	59	.	.	.
cord-006860-a3b8hyyr	4367	1	The	the	DT
cord-006860-a3b8hyyr	4367	2	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	4367	3	markers	marker	NNS
cord-006860-a3b8hyyr	4367	4	of	of	IN
cord-006860-a3b8hyyr	4367	5	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4367	6	activation	activation	NN
cord-006860-a3b8hyyr	4367	7	(	(	-LRB-
cord-006860-a3b8hyyr	4367	8	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4367	9	-	-	HYPH
cord-006860-a3b8hyyr	4367	10	amithrombin	amithrombin	NNP
cord-006860-a3b8hyyr	4367	11	III	III	NNP
cord-006860-a3b8hyyr	4367	12	complex	complex	NN
cord-006860-a3b8hyyr	4367	13	(	(	-LRB-
cord-006860-a3b8hyyr	4367	14	'	'	``
cord-006860-a3b8hyyr	4367	15	rAT	rAT	NNP
cord-006860-a3b8hyyr	4367	16	)	)	-RRB-
cord-006860-a3b8hyyr	4367	17	,	,	.
cord-006860-a3b8hyyr	4368	1	prothrombin	prothrombin	NNP
cord-006860-a3b8hyyr	4368	2	fragmem	fragmem	NNP
cord-006860-a3b8hyyr	4368	3	F	F	NNP
cord-006860-a3b8hyyr	4368	4	1	1	CD
cord-006860-a3b8hyyr	4368	5	+	+	SYM
cord-006860-a3b8hyyr	4368	6	2	2	CD
cord-006860-a3b8hyyr	4368	7	(	(	-LRB-
cord-006860-a3b8hyyr	4368	8	pl+2	pl+2	NNP
cord-006860-a3b8hyyr	4368	9	)	)	-RRB-
cord-006860-a3b8hyyr	4368	10	,	,	,
cord-006860-a3b8hyyr	4368	11	D	d	NN
cord-006860-a3b8hyyr	4368	12	-	-	HYPH
cord-006860-a3b8hyyr	4368	13	dimer	dimer	NN
cord-006860-a3b8hyyr	4368	14	)	)	-RRB-
cord-006860-a3b8hyyr	4368	15	and	and	CC
cord-006860-a3b8hyyr	4368	16	of	of	IN
cord-006860-a3b8hyyr	4368	17	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4368	18	activation	activation	NN
cord-006860-a3b8hyyr	4368	19	(	(	-LRB-
cord-006860-a3b8hyyr	4368	20	plasmin	plasmin	NN
cord-006860-a3b8hyyr	4368	21	-	-	HYPH
cord-006860-a3b8hyyr	4368	22	antiplasmin	antiplasmin	NN
cord-006860-a3b8hyyr	4368	23	complex	complex	NN
cord-006860-a3b8hyyr	4368	24	(	(	-LRB-
cord-006860-a3b8hyyr	4368	25	PAP	pap	NN
cord-006860-a3b8hyyr	4368	26	)	)	-RRB-
cord-006860-a3b8hyyr	4368	27	,	,	,
cord-006860-a3b8hyyr	4368	28	tissue	tissue	NN
cord-006860-a3b8hyyr	4368	29	type	type	NN
cord-006860-a3b8hyyr	4368	30	plasminogan	plasminogan	NN
cord-006860-a3b8hyyr	4368	31	activator	activator	NN
cord-006860-a3b8hyyr	4368	32	(	(	-LRB-
cord-006860-a3b8hyyr	4368	33	t	t	NNP
cord-006860-a3b8hyyr	4368	34	-	-	HYPH
cord-006860-a3b8hyyr	4368	35	PA	PA	NNP
cord-006860-a3b8hyyr	4368	36	)	)	-RRB-
cord-006860-a3b8hyyr	4368	37	and	and	CC
cord-006860-a3b8hyyr	4368	38	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4368	39	activator	activator	NN
cord-006860-a3b8hyyr	4368	40	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4368	41	(	(	-LRB-
cord-006860-a3b8hyyr	4368	42	PAl)-I	pal)-i	CD
cord-006860-a3b8hyyr	4368	43	activities	activity	NNS
cord-006860-a3b8hyyr	4368	44	)	)	-RRB-
cord-006860-a3b8hyyr	4368	45	were	be	VBD
cord-006860-a3b8hyyr	4368	46	measured	measure	VBN
cord-006860-a3b8hyyr	4368	47	before	before	RB
cord-006860-a3b8hyyr	4368	48	,	,	,
cord-006860-a3b8hyyr	4368	49	immediately	immediately	RB
cord-006860-a3b8hyyr	4368	50	after	after	RB
cord-006860-a3b8hyyr	4368	51	,	,	,
cord-006860-a3b8hyyr	4368	52	and	and	CC
cord-006860-a3b8hyyr	4368	53	6	6	CD
cord-006860-a3b8hyyr	4368	54	hs	hs	NN
cord-006860-a3b8hyyr	4368	55	after	after	IN
cord-006860-a3b8hyyr	4368	56	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	4368	57	.	.	.
cord-006860-a3b8hyyr	4369	1	RESULTS	result	NNS
cord-006860-a3b8hyyr	4369	2	:	:	:
cord-006860-a3b8hyyr	4370	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4370	2	found	find	VBD
cord-006860-a3b8hyyr	4370	3	elevated	elevated	JJ
cord-006860-a3b8hyyr	4370	4	mean	mean	JJ
cord-006860-a3b8hyyr	4370	5	levels	level	NNS
cord-006860-a3b8hyyr	4370	6	of	of	IN
cord-006860-a3b8hyyr	4370	7	TAT	TAT	NNP
cord-006860-a3b8hyyr	4370	8	and	and	CC
cord-006860-a3b8hyyr	4370	9	Fl+2	Fl+2	NNS
cord-006860-a3b8hyyr	4370	10	in	in	IN
cord-006860-a3b8hyyr	4370	11	both	both	DT
cord-006860-a3b8hyyr	4370	12	groups	group	NNS
cord-006860-a3b8hyyr	4370	13	during	during	IN
cord-006860-a3b8hyyr	4370	14	the	the	DT
cord-006860-a3b8hyyr	4370	15	procedure	procedure	NN
cord-006860-a3b8hyyr	4370	16	,	,	,
cord-006860-a3b8hyyr	4370	17	while	while	IN
cord-006860-a3b8hyyr	4370	18	plasma	plasma	NN
cord-006860-a3b8hyyr	4370	19	coneentrafiuns	coneentrafiun	NNS
cord-006860-a3b8hyyr	4370	20	of	of	IN
cord-006860-a3b8hyyr	4370	21	D	d	NN
cord-006860-a3b8hyyr	4370	22	-	-	HYPH
cord-006860-a3b8hyyr	4370	23	dimer	dimer	NN
cord-006860-a3b8hyyr	4370	24	and	and	CC
cord-006860-a3b8hyyr	4370	25	PAP	pap	NN
cord-006860-a3b8hyyr	4370	26	remained	remain	VBD
cord-006860-a3b8hyyr	4370	27	in	in	IN
cord-006860-a3b8hyyr	4370	28	normal	normal	JJ
cord-006860-a3b8hyyr	4370	29	range	range	NN
cord-006860-a3b8hyyr	4370	30	.	.	.
cord-006860-a3b8hyyr	4371	1	Activity	activity	NN
cord-006860-a3b8hyyr	4371	2	of	of	IN
cord-006860-a3b8hyyr	4371	3	PAI-	PAI-	NNP
cord-006860-a3b8hyyr	4372	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	4372	2	was	be	VBD
cord-006860-a3b8hyyr	4372	3	not	not	RB
cord-006860-a3b8hyyr	4372	4	elevated	elevate	VBN
cord-006860-a3b8hyyr	4372	5	compared	compare	VBN
cord-006860-a3b8hyyr	4372	6	to	to	IN
cord-006860-a3b8hyyr	4372	7	normal	normal	JJ
cord-006860-a3b8hyyr	4372	8	comrol	comrol	NN
cord-006860-a3b8hyyr	4372	9	.	.	.
cord-006860-a3b8hyyr	4373	1	The	the	DT
cord-006860-a3b8hyyr	4373	2	t	t	NNP
cord-006860-a3b8hyyr	4373	3	-	-	HYPH
cord-006860-a3b8hyyr	4373	4	PA	PA	NNP
cord-006860-a3b8hyyr	4373	5	activity	activity	NN
cord-006860-a3b8hyyr	4373	6	obtained	obtain	VBD
cord-006860-a3b8hyyr	4373	7	immediately	immediately	RB
cord-006860-a3b8hyyr	4373	8	post	post	JJ
cord-006860-a3b8hyyr	4373	9	-	-	JJ
cord-006860-a3b8hyyr	4373	10	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	4373	11	showed	show	VBD
cord-006860-a3b8hyyr	4373	12	significant	significant	JJ
cord-006860-a3b8hyyr	4373	13	increase	increase	NN
cord-006860-a3b8hyyr	4373	14	in	in	IN
cord-006860-a3b8hyyr	4373	15	patients	patient	NNS
cord-006860-a3b8hyyr	4373	16	given	give	VBN
cord-006860-a3b8hyyr	4373	17	SPP	SPP	NNS
cord-006860-a3b8hyyr	4373	18	.	.	.
cord-006860-a3b8hyyr	4374	1	Primary	primary	JJ
cord-006860-a3b8hyyr	4374	2	angiologic	angiologic	JJ
cord-006860-a3b8hyyr	4374	3	success	success	NN
cord-006860-a3b8hyyr	4374	4	was	be	VBD
cord-006860-a3b8hyyr	4374	5	achieved	achieve	VBN
cord-006860-a3b8hyyr	4374	6	in	in	IN
cord-006860-a3b8hyyr	4374	7	80	80	CD
cord-006860-a3b8hyyr	4374	8	%	%	NN
cord-006860-a3b8hyyr	4374	9	of	of	IN
cord-006860-a3b8hyyr	4374	10	both	both	DT
cord-006860-a3b8hyyr	4374	11	groups	group	NNS
cord-006860-a3b8hyyr	4374	12	.	.	.
cord-006860-a3b8hyyr	4375	1	One	one	CD
cord-006860-a3b8hyyr	4375	2	patient	patient	NN
cord-006860-a3b8hyyr	4375	3	in	in	IN
cord-006860-a3b8hyyr	4375	4	each	each	DT
cord-006860-a3b8hyyr	4375	5	group	group	NN
cord-006860-a3b8hyyr	4375	6	had	have	VBD
cord-006860-a3b8hyyr	4375	7	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	4375	8	ischaemia	ischaemia	NN
cord-006860-a3b8hyyr	4375	9	and	and	CC
cord-006860-a3b8hyyr	4375	10	emergency	emergency	NN
cord-006860-a3b8hyyr	4375	11	interventions	intervention	NNS
cord-006860-a3b8hyyr	4375	12	(	(	-LRB-
cord-006860-a3b8hyyr	4375	13	angioplasty	angioplasty	NN
cord-006860-a3b8hyyr	4375	14	,	,	,
cord-006860-a3b8hyyr	4375	15	stent	stent	NN
cord-006860-a3b8hyyr	4375	16	,	,	,
cord-006860-a3b8hyyr	4375	17	bypass	bypass	NN
cord-006860-a3b8hyyr	4375	18	surgery	surgery	NN
cord-006860-a3b8hyyr	4375	19	)	)	-RRB-
cord-006860-a3b8hyyr	4375	20	were	be	VBD
cord-006860-a3b8hyyr	4375	21	performed	perform	VBN
cord-006860-a3b8hyyr	4375	22	.	.	.
cord-006860-a3b8hyyr	4376	1	One	one	CD
cord-006860-a3b8hyyr	4376	2	patient	patient	NN
cord-006860-a3b8hyyr	4376	3	receiving	receive	VBG
cord-006860-a3b8hyyr	4376	4	adjunctive	adjunctive	JJ
cord-006860-a3b8hyyr	4376	5	therapy	therapy	NN
cord-006860-a3b8hyyr	4376	6	died	die	VBD
cord-006860-a3b8hyyr	4376	7	in	in	IN
cord-006860-a3b8hyyr	4376	8	cardiogenic	cardiogenic	JJ
cord-006860-a3b8hyyr	4376	9	shock	shock	NN
cord-006860-a3b8hyyr	4376	10	within	within	IN
cord-006860-a3b8hyyr	4376	11	24hs	24hs	JJ
cord-006860-a3b8hyyr	4376	12	aRer	aRer	NNP
cord-006860-a3b8hyyr	4376	13	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	4376	14	.	.	.
cord-006860-a3b8hyyr	4377	1	Major	major	JJ
cord-006860-a3b8hyyr	4377	2	bleeding	bleeding	NN
cord-006860-a3b8hyyr	4377	3	was	be	VBD
cord-006860-a3b8hyyr	4377	4	observed	observe	VBN
cord-006860-a3b8hyyr	4377	5	in	in	IN
cord-006860-a3b8hyyr	4377	6	one	one	CD
cord-006860-a3b8hyyr	4377	7	patient	patient	NN
cord-006860-a3b8hyyr	4377	8	given	give	VBN
cord-006860-a3b8hyyr	4377	9	SPP	spp	NN
cord-006860-a3b8hyyr	4377	10	.	.	.
cord-006860-a3b8hyyr	4378	1	CONCLUSION	conclusion	NN
cord-006860-a3b8hyyr	4378	2	:	:	:
cord-006860-a3b8hyyr	4379	1	No	no	DT
cord-006860-a3b8hyyr	4379	2	significant	significant	JJ
cord-006860-a3b8hyyr	4379	3	intracoronary	intracoronary	JJ
cord-006860-a3b8hyyr	4379	4	haemostatic	haemostatic	JJ
cord-006860-a3b8hyyr	4379	5	activation	activation	NN
cord-006860-a3b8hyyr	4379	6	occurred	occur	VBD
cord-006860-a3b8hyyr	4379	7	in	in	IN
cord-006860-a3b8hyyr	4379	8	the	the	DT
cord-006860-a3b8hyyr	4379	9	majority	majority	NN
cord-006860-a3b8hyyr	4379	10	of	of	IN
cord-006860-a3b8hyyr	4379	11	patients	patient	NNS
cord-006860-a3b8hyyr	4379	12	during	during	IN
cord-006860-a3b8hyyr	4379	13	and	and	CC
cord-006860-a3b8hyyr	4379	14	up	up	IN
cord-006860-a3b8hyyr	4379	15	to	to	TO
cord-006860-a3b8hyyr	4379	16	6hs	6hs	NN
cord-006860-a3b8hyyr	4379	17	after	after	IN
cord-006860-a3b8hyyr	4379	18	PTCA	PTCA	NNP
cord-006860-a3b8hyyr	4379	19	.	.	.
cord-006860-a3b8hyyr	4380	1	Treatment	treatment	NN
cord-006860-a3b8hyyr	4380	2	with	with	IN
cord-006860-a3b8hyyr	4380	3	SPP	SPP	NNS
cord-006860-a3b8hyyr	4380	4	was	be	VBD
cord-006860-a3b8hyyr	4380	5	associated	associate	VBN
cord-006860-a3b8hyyr	4380	6	with	with	IN
cord-006860-a3b8hyyr	4380	7	enhanced	enhance	VBN
cord-006860-a3b8hyyr	4380	8	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4380	9	activity	activity	NN
cord-006860-a3b8hyyr	4380	10	.	.	.
cord-006860-a3b8hyyr	4381	1	The	the	DT
cord-006860-a3b8hyyr	4381	2	benefits	benefit	NNS
cord-006860-a3b8hyyr	4381	3	and	and	CC
cord-006860-a3b8hyyr	4381	4	risks	risk	NNS
cord-006860-a3b8hyyr	4381	5	of	of	IN
cord-006860-a3b8hyyr	4381	6	adding	add	VBG
cord-006860-a3b8hyyr	4381	7	SPP	SPP	NNP
cord-006860-a3b8hyyr	4381	8	to	to	IN
cord-006860-a3b8hyyr	4381	9	heparm	heparm	NNS
cord-006860-a3b8hyyr	4381	10	and	and	CC
cord-006860-a3b8hyyr	4381	11	aspirin	aspirin	NN
cord-006860-a3b8hyyr	4381	12	should	should	MD
cord-006860-a3b8hyyr	4381	13	be	be	VB
cord-006860-a3b8hyyr	4381	14	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	4381	15	by	by	IN
cord-006860-a3b8hyyr	4381	16	further	further	JJ
cord-006860-a3b8hyyr	4381	17	studies	study	NNS
cord-006860-a3b8hyyr	4381	18	,	,	,
cord-006860-a3b8hyyr	4381	19	 	 	_SP
cord-006860-a3b8hyyr	4381	20	In	in	IN
cord-006860-a3b8hyyr	4381	21	July	July	NNP
cord-006860-a3b8hyyr	4381	22	19,¢1	19,¢1	CD
cord-006860-a3b8hyyr	4381	23	the	the	DT
cord-006860-a3b8hyyr	4381	24	Paul	Paul	NNP
cord-006860-a3b8hyyr	4381	25	Ehdich	Ehdich	NNP
cord-006860-a3b8hyyr	4381	26	Institute	Institute	NNP
cord-006860-a3b8hyyr	4381	27	became	become	VBD
cord-006860-a3b8hyyr	4381	28	responsible	responsible	JJ
cord-006860-a3b8hyyr	4381	29	for	for	IN
cord-006860-a3b8hyyr	4381	30	quality	quality	NN
cord-006860-a3b8hyyr	4381	31	and	and	CC
cord-006860-a3b8hyyr	4381	32	safety	safety	NN
cord-006860-a3b8hyyr	4381	33	of	of	IN
cord-006860-a3b8hyyr	4381	34	bt	bt	NNP
cord-006860-a3b8hyyr	4381	35	~	~	NNP
cord-006860-a3b8hyyr	4381	36	d	d	XX
cord-006860-a3b8hyyr	4381	37	and	and	CC
cord-006860-a3b8hyyr	4381	38	blood	blood	NN
cord-006860-a3b8hyyr	4381	39	products	product	NNS
cord-006860-a3b8hyyr	4381	40	.	.	.
cord-006860-a3b8hyyr	4382	1	Since	since	IN
cord-006860-a3b8hyyr	4382	2	~his	~his	NNP
cord-006860-a3b8hyyr	4382	3	time	time	NN
cord-006860-a3b8hyyr	4382	4	,	,	,
cord-006860-a3b8hyyr	4382	5	batch	batch	NN
cord-006860-a3b8hyyr	4382	6	m	m	NNP
cord-006860-a3b8hyyr	4382	7	~	~	NNP
cord-006860-a3b8hyyr	4382	8	se	se	FW
cord-006860-a3b8hyyr	4382	9	of	of	IN
cord-006860-a3b8hyyr	4382	10	PPSB	PPSB	NNP
cord-006860-a3b8hyyr	4382	11	and	and	CC
cord-006860-a3b8hyyr	4382	12	Factor	Factor	NNP
cord-006860-a3b8hyyr	4382	13	IX	IX	NNP
cord-006860-a3b8hyyr	4382	14	prapamtions	prapamtion	NNS
cord-006860-a3b8hyyr	4382	15	were	be	VBD
cord-006860-a3b8hyyr	4382	16	carded	card	VBN
cord-006860-a3b8hyyr	4382	17	out	out	RP
cord-006860-a3b8hyyr	4382	18	regularly	regularly	RB
cord-006860-a3b8hyyr	4382	19	,	,	,
cord-006860-a3b8hyyr	4382	20	whereas	whereas	IN
cord-006860-a3b8hyyr	4382	21	Ihe	Ihe	NNP
cord-006860-a3b8hyyr	4382	22	obligatoP	obligatoP	NNP
cord-006860-a3b8hyyr	4382	23	i	i	PRP
cord-006860-a3b8hyyr	4382	24	testlng	testlng	NN
cord-006860-a3b8hyyr	4382	25	of	of	IN
cord-006860-a3b8hyyr	4382	26	all	all	DT
cord-006860-a3b8hyyr	4382	27	other	other	JJ
cord-006860-a3b8hyyr	4382	28	products	product	NNS
cord-006860-a3b8hyyr	4382	29	derived	derive	VBN
cord-006860-a3b8hyyr	4382	30	frem	frem	NN
cord-006860-a3b8hyyr	4382	31	pooled	pool	VBN
cord-006860-a3b8hyyr	4382	32	plasma	plasma	NN
cord-006860-a3b8hyyr	4382	33	will	will	MD
cord-006860-a3b8hyyr	4382	34	be	be	VB
cord-006860-a3b8hyyr	4382	35	starling	starling	NN
cord-006860-a3b8hyyr	4382	36	in	in	IN
cord-006860-a3b8hyyr	4382	37	Janualy	Janualy	NNP
cord-006860-a3b8hyyr	4382	38	1996	1996	CD
cord-006860-a3b8hyyr	4382	39	.	.	.
cord-006860-a3b8hyyr	4383	1	The	the	DT
cord-006860-a3b8hyyr	4383	2	European	European	NNP
cord-006860-a3b8hyyr	4383	3	Pharmacopoeia	Pharmacopoeia	NNP
cord-006860-a3b8hyyr	4383	4	does	do	VBZ
cord-006860-a3b8hyyr	4383	5	.or	.or	TO
cord-006860-a3b8hyyr	4383	6	contain	contain	VB
cord-006860-a3b8hyyr	4383	7	directions	direction	NNS
cord-006860-a3b8hyyr	4383	8	for	for	IN
cord-006860-a3b8hyyr	4383	9	the	the	DT
cord-006860-a3b8hyyr	4383	10	quality	quality	NN
cord-006860-a3b8hyyr	4383	11	control	control	NN
cord-006860-a3b8hyyr	4383	12	of	of	IN
cord-006860-a3b8hyyr	4383	13	PPSB	PPSB	NNP
cord-006860-a3b8hyyr	4383	14	preparations	preparation	NNS
cord-006860-a3b8hyyr	4383	15	.	.	.
cord-006860-a3b8hyyr	4384	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	4384	2	,	,	,
cord-006860-a3b8hyyr	4384	3	Ifua	Ifua	NNP
cord-006860-a3b8hyyr	4384	4	~	~	NFP
cord-006860-a3b8hyyr	4384	5	coneenning	coneenne	VBG
cord-006860-a3b8hyyr	4384	6	Factor	Factor	NNP
cord-006860-a3b8hyyr	4384	7	IX	IX	NNP
cord-006860-a3b8hyyr	4384	8	clotting	clotting	NN
cord-006860-a3b8hyyr	4384	9	concentrates	concentrate	NNS
cord-006860-a3b8hyyr	4384	10	are	be	VBP
cord-006860-a3b8hyyr	4384	11	applied	apply	VBN
cord-006860-a3b8hyyr	4384	12	,	,	,
cord-006860-a3b8hyyr	4384	13	Ircludmg	Ircludmg	NNP
cord-006860-a3b8hyyr	4384	14	the	the	DT
cord-006860-a3b8hyyr	4384	15	non	non	JJ
cord-006860-a3b8hyyr	4384	16	activated	activate	VBN
cord-006860-a3b8hyyr	4384	17	PTT	PTT	NNP
cord-006860-a3b8hyyr	4384	18	and	and	CC
cord-006860-a3b8hyyr	4384	19	the	the	DT
cord-006860-a3b8hyyr	4384	20	classical	classical	JJ
cord-006860-a3b8hyyr	4384	21	tkrombln	tkrombln	NNP
cord-006860-a3b8hyyr	4384	22	test	test	NN
cord-006860-a3b8hyyr	4385	1	These	these	DT
cord-006860-a3b8hyyr	4385	2	m	m	LS
cord-006860-a3b8hyyr	4385	3	~	~	NFP
cord-006860-a3b8hyyr	4385	4	ods	ods	NNPS
cord-006860-a3b8hyyr	4385	5	are	be	VBP
cord-006860-a3b8hyyr	4385	6	not	not	RB
cord-006860-a3b8hyyr	4385	7	su'rlable	su'rlable	JJ
cord-006860-a3b8hyyr	4385	8	for	for	IN
cord-006860-a3b8hyyr	4385	9	reliable	reliable	JJ
cord-006860-a3b8hyyr	4385	10	exclusion	exclusion	NN
cord-006860-a3b8hyyr	4385	11	of	of	IN
cord-006860-a3b8hyyr	4385	12	Ituombogenk	Ituombogenk	NNP
cord-006860-a3b8hyyr	4385	13	~	~	NFP
cord-006860-a3b8hyyr	4385	14	b/	b/	JJ
cord-006860-a3b8hyyr	4385	15	,	,	,
cord-006860-a3b8hyyr	4385	16	of	of	IN
cord-006860-a3b8hyyr	4385	17	PP	PP	NNP
cord-006860-a3b8hyyr	4385	18	,	,	,
cord-006860-a3b8hyyr	4385	19	Sfl	Sfl	NNP
cord-006860-a3b8hyyr	4385	20	,	,	,
cord-006860-a3b8hyyr	4385	21	because	because	IN
cord-006860-a3b8hyyr	4385	22	Vlla	Vlla	NNP
cord-006860-a3b8hyyr	4385	23	actlvRy	actlvRy	NNP
cord-006860-a3b8hyyr	4385	24	is	be	VBZ
cord-006860-a3b8hyyr	4385	25	not	not	RB
cord-006860-a3b8hyyr	4385	26	d~.	d~.	JJ
cord-006860-a3b8hyyr	4386	1	A	a	DT
cord-006860-a3b8hyyr	4386	2	hllhedo	hllhedo	NN
cord-006860-a3b8hyyr	4386	3	unsolved	unsolved	JJ
cord-006860-a3b8hyyr	4386	4	problem	problem	NN
cord-006860-a3b8hyyr	4386	5	is	be	VBZ
cord-006860-a3b8hyyr	4386	6	the	the	DT
cord-006860-a3b8hyyr	4386	7	high	high	JJ
cord-006860-a3b8hyyr	4386	8	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	4386	9	Of	of	IN
cord-006860-a3b8hyyr	4386	10	file	file	NN
cord-006860-a3b8hyyr	4386	11	classical	classical	JJ
cord-006860-a3b8hyyr	4386	12	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4386	13	test	test	NN
cord-006860-a3b8hyyr	4386	14	often	often	RB
cord-006860-a3b8hyyr	4386	15	not	not	RB
cord-006860-a3b8hyyr	4386	16	correlating	correlate	VBG
cord-006860-a3b8hyyr	4386	17	with	with	IN
cord-006860-a3b8hyyr	4386	18	~	~	ADD
cord-006860-a3b8hyyr	4386	19	data	datum	NNS
cord-006860-a3b8hyyr	4386	20	of	of	IN
cord-006860-a3b8hyyr	4386	21	thrombogenlci~.	thrombogenlci~.	NN
cord-006860-a3b8hyyr	4387	1	In	in	IN
cord-006860-a3b8hyyr	4387	2	ordm	ordm	NNP
cord-006860-a3b8hyyr	4388	1	tD	td	NN
cord-006860-a3b8hyyr	4388	2	es	es	XX
cord-006860-a3b8hyyr	4388	3	~	~	NFP
cord-006860-a3b8hyyr	4388	4	abl~	abl~	CD
cord-006860-a3b8hyyr	4388	5	an	an	DT
cord-006860-a3b8hyyr	4388	6	effective	effective	JJ
cord-006860-a3b8hyyr	4388	7	quality	quality	NN
cord-006860-a3b8hyyr	4388	8	conlrd	conlrd	NN
cord-006860-a3b8hyyr	4388	9	protocol	protocol	NN
cord-006860-a3b8hyyr	4388	10	,	,	,
cord-006860-a3b8hyyr	4388	11	different	different	JJ
cord-006860-a3b8hyyr	4388	12	methods	method	NNS
cord-006860-a3b8hyyr	4388	13	for	for	IN
cord-006860-a3b8hyyr	4388	14	the	the	DT
cord-006860-a3b8hyyr	4388	15	qual	qual	JJ
cord-006860-a3b8hyyr	4388	16	~	~	NFP
cord-006860-a3b8hyyr	4388	17	ative	ative	JJ
cord-006860-a3b8hyyr	4388	18	detennlna	detennlna	NNP
cord-006860-a3b8hyyr	4388	19	~	~	NFP
cord-006860-a3b8hyyr	4388	20	on	on	IN
cord-006860-a3b8hyyr	4388	21	of	of	IN
cord-006860-a3b8hyyr	4388	22	Ila	Ila	NNP
cord-006860-a3b8hyyr	4388	23	,	,	,
cord-006860-a3b8hyyr	4388	24	Vlla	Vlla	NNP
cord-006860-a3b8hyyr	4388	25	.	.	.
cord-006860-a3b8hyyr	4389	1	IXa	IXa	NNS
cord-006860-a3b8hyyr	4389	2	,	,	,
cord-006860-a3b8hyyr	4389	3	and	and	CC
cord-006860-a3b8hyyr	4389	4	Xa	Xa	NNP
cord-006860-a3b8hyyr	4389	5	(	(	-LRB-
cord-006860-a3b8hyyr	4389	6	chrornogenic	chrornogenic	NNP
cord-006860-a3b8hyyr	4389	7	,	,	,
cord-006860-a3b8hyyr	4389	8	fluorege	fluorege	NNP
cord-006860-a3b8hyyr	4389	9	~	~	NFP
cord-006860-a3b8hyyr	4389	10	c	c	NNP
cord-006860-a3b8hyyr	4389	11	clolfing	clolfing	NNP
cord-006860-a3b8hyyr	4389	12	reactions	reaction	NNS
cord-006860-a3b8hyyr	4389	13	)	)	-RRB-
cord-006860-a3b8hyyr	4389	14	wera	wera	NNP
cord-006860-a3b8hyyr	4389	15	instaUed	instaUed	NNP
cord-006860-a3b8hyyr	4389	16	.	.	.
cord-006860-a3b8hyyr	4390	1	In	in	IN
cord-006860-a3b8hyyr	4390	2	agreement	agreement	NN
cord-006860-a3b8hyyr	4390	3	with	with	IN
cord-006860-a3b8hyyr	4390	4	the	the	DT
cord-006860-a3b8hyyr	4390	5	[	[	-LRB-
cord-006860-a3b8hyyr	4390	6	deralure	deralure	NNP
cord-006860-a3b8hyyr	4390	7	,	,	,
cord-006860-a3b8hyyr	4390	8	considerable	considerable	JJ
cord-006860-a3b8hyyr	4390	9	differences	difference	NNS
cord-006860-a3b8hyyr	4390	10	were	be	VBD
cord-006860-a3b8hyyr	4390	11	found	find	VBN
cord-006860-a3b8hyyr	4390	12	among	among	IN
cord-006860-a3b8hyyr	4390	13	the	the	DT
cord-006860-a3b8hyyr	4390	14	PPSB	PPSB	NNP
cord-006860-a3b8hyyr	4390	15	pr	pr	NNP
cord-006860-a3b8hyyr	4390	16	~	~	NNP
cord-006860-a3b8hyyr	4390	17	ons	on	NNS
cord-006860-a3b8hyyr	4390	18	registered	register	VBN
cord-006860-a3b8hyyr	4390	19	in	in	IN
cord-006860-a3b8hyyr	4390	20	Germany	Germany	NNP
cord-006860-a3b8hyyr	4390	21	.	.	.
cord-006860-a3b8hyyr	4391	1	Cedain	Cedain	NNP
cord-006860-a3b8hyyr	4391	2	amounts	amount	NNS
cord-006860-a3b8hyyr	4391	3	of	of	IN
cord-006860-a3b8hyyr	4391	4	activated	activate	VBN
cord-006860-a3b8hyyr	4391	5	do	do	NN
cord-006860-a3b8hyyr	4392	1	~ng	~ng	JJ
cord-006860-a3b8hyyr	4392	2	racers	racer	NNS
cord-006860-a3b8hyyr	4392	3	may	may	MD
cord-006860-a3b8hyyr	4392	4	be	be	VB
cord-006860-a3b8hyyr	4392	5	well	well	RB
cord-006860-a3b8hyyr	4392	6	tole	tole	NNP
cord-006860-a3b8hyyr	4392	7	~	~	NFP
cord-006860-a3b8hyyr	4392	8	ted	ted	NNP
cord-006860-a3b8hyyr	4392	9	in	in	IN
cord-006860-a3b8hyyr	4392	10	redp	redp	NNP
cord-006860-a3b8hyyr	4392	11	/	/	SYM
cord-006860-a3b8hyyr	4392	12	ents	ent	NNS
cord-006860-a3b8hyyr	4392	13	.	.	.
cord-006860-a3b8hyyr	4393	1	~no	~no	NNP
cord-006860-a3b8hyyr	4393	2	are	be	VBP
cord-006860-a3b8hyyr	4393	3	in	in	IN
cord-006860-a3b8hyyr	4393	4	a	a	DT
cord-006860-a3b8hyyr	4393	5	steady	steady	JJ
cord-006860-a3b8hyyr	4393	6	state	state	NN
cord-006860-a3b8hyyr	4393	7	condition	condition	NN
cord-006860-a3b8hyyr	4393	8	.	.	.
cord-006860-a3b8hyyr	4394	1	However	however	RB
cord-006860-a3b8hyyr	4394	2	,	,	,
cord-006860-a3b8hyyr	4394	3	in	in	IN
cord-006860-a3b8hyyr	4394	4	severely	severely	RB
cord-006860-a3b8hyyr	4394	5	ill	ill	JJ
cord-006860-a3b8hyyr	4394	6	patienls	patienls	NN
cord-006860-a3b8hyyr	4394	7	,	,	,
cord-006860-a3b8hyyr	4394	8	eg	eg	XX
cord-006860-a3b8hyyr	4394	9	.	.	.
cord-006860-a3b8hyyr	4394	10	post	post	NNP
cord-006860-a3b8hyyr	4394	11	operatively	operatively	RB
cord-006860-a3b8hyyr	4394	12	,	,	,
cord-006860-a3b8hyyr	4394	13	Tissue	Tissue	NNP
cord-006860-a3b8hyyr	4394	14	Factor	Factor	NNP
cord-006860-a3b8hyyr	4394	15	may	may	MD
cord-006860-a3b8hyyr	4394	16	be	be	VB
cord-006860-a3b8hyyr	4394	17	expressed	express	VBN
cord-006860-a3b8hyyr	4394	18	which	which	WDT
cord-006860-a3b8hyyr	4394	19	pofenllatesthe	pofenllatesthe	NNP
cord-006860-a3b8hyyr	4394	20	dsk	dsk	NNP
cord-006860-a3b8hyyr	4394	21	of	of	IN
cord-006860-a3b8hyyr	4394	22	~aclor	~aclor	NNP
cord-006860-a3b8hyyr	4395	1	Vlta	Vlta	NNP
cord-006860-a3b8hyyr	4395	2	.	.	.
cord-006860-a3b8hyyr	4396	1	In	in	IN
cord-006860-a3b8hyyr	4396	2	the	the	DT
cord-006860-a3b8hyyr	4396	3	case	case	NN
cord-006860-a3b8hyyr	4396	4	of	of	IN
cord-006860-a3b8hyyr	4396	5	a	a	DT
cord-006860-a3b8hyyr	4396	6	certain	certain	JJ
cord-006860-a3b8hyyr	4396	7	PPSB	PPSB	NNP
cord-006860-a3b8hyyr	4396	8	preparation	preparation	NN
cord-006860-a3b8hyyr	4396	9	hlgh	hlgh	NN
cord-006860-a3b8hyyr	4396	10	¢onceatratio~	¢onceatratio~	NNPS
cord-006860-a3b8hyyr	4396	11	of	of	IN
cord-006860-a3b8hyyr	4396	12	acthrated	acthrate	VBN
cord-006860-a3b8hyyr	4396	13	cto~	cto~	ADD
cord-006860-a3b8hyyr	4397	1	ng	ng	NNP
cord-006860-a3b8hyyr	4397	2	factors	factor	NNS
cord-006860-a3b8hyyr	4397	3	,	,	,
cord-006860-a3b8hyyr	4397	4	especially	especially	RB
cord-006860-a3b8hyyr	4397	5	~vated	~vated	NNP
cord-006860-a3b8hyyr	4397	6	factor	factor	NN
cord-006860-a3b8hyyr	4397	7	VII	vii	NN
cord-006860-a3b8hyyr	4397	8	,	,	,
cord-006860-a3b8hyyr	4397	9	cotmlaled	cotmlale	VBN
cord-006860-a3b8hyyr	4397	10	with	with	IN
cord-006860-a3b8hyyr	4397	11	fatal	fatal	JJ
cord-006860-a3b8hyyr	4397	12	COmlffcal	COmlffcal	NNP
cord-006860-a3b8hyyr	4398	1	~ns	~ns	NNP
cord-006860-a3b8hyyr	4398	2	,	,	,
cord-006860-a3b8hyyr	4398	3	Evaluating	evaluate	VBG
cord-006860-a3b8hyyr	4398	4	~	~	NFP
cord-006860-a3b8hyyr	4398	5	expe~	expe~	NNP
cord-006860-a3b8hyyr	4398	6	concenlralbn	concenlralbn	NNP
cord-006860-a3b8hyyr	4398	7	limits	limit	NNS
cord-006860-a3b8hyyr	4398	8	for	for	IN
cord-006860-a3b8hyyr	4398	9	adJvated	adjvated	JJ
cord-006860-a3b8hyyr	4398	10	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4398	11	co	co	NN
cord-006860-a3b8hyyr	4398	12	~	~	CD
cord-006860-a3b8hyyr	4398	13	np~.x	np~.x	JJ
cord-006860-a3b8hyyr	4398	14	factors	factor	NNS
cord-006860-a3b8hyyr	4398	15	as	as	IN
cord-006860-a3b8hyyr	4398	16	prerequisite	prerequisite	NN
cord-006860-a3b8hyyr	4398	17	for	for	IN
cord-006860-a3b8hyyr	4398	18	~e	~e	ADD
cord-006860-a3b8hyyr	4399	1	batch	batch	NNP
cord-006860-a3b8hyyr	4399	2	r	r	NNP
cord-006860-a3b8hyyr	4399	3	~	~	NFP
cord-006860-a3b8hyyr	4399	4	ease	ease	NN
cord-006860-a3b8hyyr	4399	5	have	have	VB
cord-006860-a3b8hyyr	4399	6	to	to	TO
cord-006860-a3b8hyyr	4399	7	be	be	VB
cord-006860-a3b8hyyr	4399	8	applied	apply	VBN
cord-006860-a3b8hyyr	4399	9	.	.	.
cord-006860-a3b8hyyr	4400	1	Aprotinin	Aprotinin	NNP
cord-006860-a3b8hyyr	4400	2	is	be	VBZ
cord-006860-a3b8hyyr	4400	3	used	use	VBN
cord-006860-a3b8hyyr	4400	4	as	as	IN
cord-006860-a3b8hyyr	4400	5	a	a	DT
cord-006860-a3b8hyyr	4400	6	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	4400	7	agent	agent	NN
cord-006860-a3b8hyyr	4400	8	in	in	IN
cord-006860-a3b8hyyr	4400	9	cardiopulmonary	cardiopulmonary	JJ
cord-006860-a3b8hyyr	4400	10	bypass	bypass	NN
cord-006860-a3b8hyyr	4400	11	surgery	surgery	NN
cord-006860-a3b8hyyr	4400	12	and	and	CC
cord-006860-a3b8hyyr	4400	13	other	other	JJ
cord-006860-a3b8hyyr	4400	14	indications	indication	NNS
cord-006860-a3b8hyyr	4400	15	where	where	WRB
cord-006860-a3b8hyyr	4400	16	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	4400	17	compromise	compromise	NN
cord-006860-a3b8hyyr	4400	18	results	result	NNS
cord-006860-a3b8hyyr	4400	19	in	in	IN
cord-006860-a3b8hyyr	4400	20	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	4400	21	manifestations	manifestation	NNS
cord-006860-a3b8hyyr	4400	22	.	.	.
cord-006860-a3b8hyyr	4401	1	The	the	DT
cord-006860-a3b8hyyr	4401	2	mechanism	mechanism	NN
cord-006860-a3b8hyyr	4401	3	by	by	IN
cord-006860-a3b8hyyr	4401	4	which	which	WDT
cord-006860-a3b8hyyr	4401	5	this	this	DT
cord-006860-a3b8hyyr	4401	6	agent	agent	NN
cord-006860-a3b8hyyr	4401	7	produces	produce	VBZ
cord-006860-a3b8hyyr	4401	8	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	4401	9	effects	effect	NNS
cord-006860-a3b8hyyr	4401	10	is	be	VBZ
cord-006860-a3b8hyyr	4401	11	not	not	RB
cord-006860-a3b8hyyr	4401	12	known	know	VBN
cord-006860-a3b8hyyr	4401	13	,	,	,
cord-006860-a3b8hyyr	4401	14	however	however	RB
cord-006860-a3b8hyyr	4401	15	,	,	,
cord-006860-a3b8hyyr	4401	16	inhibition	inhibition	NN
cord-006860-a3b8hyyr	4401	17	of	of	IN
cord-006860-a3b8hyyr	4401	18	serine	serine	JJ
cord-006860-a3b8hyyr	4401	19	proteasas	proteasas	NN
cord-006860-a3b8hyyr	4401	20	such	such	JJ
cord-006860-a3b8hyyr	4401	21	as	as	IN
cord-006860-a3b8hyyr	4401	22	plasmin	plasmin	NNP
cord-006860-a3b8hyyr	4401	23	,	,	,
cord-006860-a3b8hyyr	4401	24	kallikrein	kallikrein	NNP
cord-006860-a3b8hyyr	4401	25	and	and	CC
cord-006860-a3b8hyyr	4401	26	dastase	dastase	NNP
cord-006860-a3b8hyyr	4401	27	and	and	CC
cord-006860-a3b8hyyr	4401	28	modulataion	modulataion	NN
cord-006860-a3b8hyyr	4401	29	of	of	IN
cord-006860-a3b8hyyr	4401	30	platelet	platelet	NN
cord-006860-a3b8hyyr	4401	31	receptors	receptor	NNS
cord-006860-a3b8hyyr	4401	32	have	have	VBP
cord-006860-a3b8hyyr	4401	33	been	be	VBN
cord-006860-a3b8hyyr	4401	34	considered	consider	VBN
cord-006860-a3b8hyyr	4401	35	as	as	IN
cord-006860-a3b8hyyr	4401	36	possible	possible	JJ
cord-006860-a3b8hyyr	4401	37	target	target	NN
cord-006860-a3b8hyyr	4401	38	sites	site	NNS
cord-006860-a3b8hyyr	4401	39	.	.	.
cord-006860-a3b8hyyr	4402	1	To	to	TO
cord-006860-a3b8hyyr	4402	2	determine	determine	VB
cord-006860-a3b8hyyr	4402	3	the	the	DT
cord-006860-a3b8hyyr	4402	4	effect	effect	NN
cord-006860-a3b8hyyr	4402	5	of	of	IN
cord-006860-a3b8hyyr	4402	6	aprotinin	aprotinin	NN
cord-006860-a3b8hyyr	4402	7	on	on	IN
cord-006860-a3b8hyyr	4402	8	tissue	tissue	NN
cord-006860-a3b8hyyr	4402	9	factor	factor	NN
cord-006860-a3b8hyyr	4402	10	mediated	mediate	VBN
cord-006860-a3b8hyyr	4402	11	activation	activation	NN
cord-006860-a3b8hyyr	4402	12	of	of	IN
cord-006860-a3b8hyyr	4402	13	human	human	JJ
cord-006860-a3b8hyyr	4402	14	platelets	platelet	NNS
cord-006860-a3b8hyyr	4402	15	,	,	,
cord-006860-a3b8hyyr	4402	16	whole	whole	JJ
cord-006860-a3b8hyyr	4402	17	blood	blood	NN
cord-006860-a3b8hyyr	4402	18	samples	sample	NNS
cord-006860-a3b8hyyr	4402	19	were	be	VBD
cord-006860-a3b8hyyr	4402	20	drawn	draw	VBN
cord-006860-a3b8hyyr	4402	21	at	at	IN
cord-006860-a3b8hyyr	4402	22	baseline	baseline	NN
cord-006860-a3b8hyyr	4402	23	and	and	CC
cord-006860-a3b8hyyr	4402	24	24	24	CD
cord-006860-a3b8hyyr	4402	25	hours	hour	NNS
cord-006860-a3b8hyyr	4403	1	aider	aider	NNP
cord-006860-a3b8hyyr	4403	2	aspirin	aspirin	NNP
cord-006860-a3b8hyyr	4403	3	(	(	-LRB-
cord-006860-a3b8hyyr	4403	4	650	650	CD
cord-006860-a3b8hyyr	4403	5	mg	mg	NN
cord-006860-a3b8hyyr	4403	6	PO	po	NN
cord-006860-a3b8hyyr	4403	7	)	)	-RRB-
cord-006860-a3b8hyyr	4403	8	ingestion	ingestion	NN
cord-006860-a3b8hyyr	4403	9	(	(	-LRB-
cord-006860-a3b8hyyr	4403	10	n=5	n=5	RB
cord-006860-a3b8hyyr	4403	11	)	)	-RRB-
cord-006860-a3b8hyyr	4403	12	.	.	.
cord-006860-a3b8hyyr	4404	1	Blood	blood	NN
cord-006860-a3b8hyyr	4404	2	samples	sample	NNS
cord-006860-a3b8hyyr	4404	3	were	be	VBD
cord-006860-a3b8hyyr	4404	4	supplemented	supplement	VBN
cord-006860-a3b8hyyr	4404	5	with	with	IN
cord-006860-a3b8hyyr	4404	6	saline	saline	NN
cord-006860-a3b8hyyr	4404	7	and	and	CC
cord-006860-a3b8hyyr	4404	8	aprotinin	aprotinin	NNP
cord-006860-a3b8hyyr	4404	9	(	(	-LRB-
cord-006860-a3b8hyyr	4404	10	40	40	CD
cord-006860-a3b8hyyr	4404	11	ug	ug	NNP
cord-006860-a3b8hyyr	4404	12	/	/	SYM
cord-006860-a3b8hyyr	4404	13	ml	ml	NN
cord-006860-a3b8hyyr	4404	14	)	)	-RRB-
cord-006860-a3b8hyyr	4404	15	and	and	CC
cord-006860-a3b8hyyr	4404	16	tissue	tissue	NN
cord-006860-a3b8hyyr	4404	17	factor	factor	NN
cord-006860-a3b8hyyr	4404	18	activation	activation	NN
cord-006860-a3b8hyyr	4404	19	was	be	VBD
cord-006860-a3b8hyyr	4404	20	studied	study	VBN
cord-006860-a3b8hyyr	4404	21	at	at	IN
cord-006860-a3b8hyyr	4404	22	200	200	CD
cord-006860-a3b8hyyr	4405	1	pg	pg	NNP
cord-006860-a3b8hyyr	4405	2	/	/	SYM
cord-006860-a3b8hyyr	4405	3	ral	ral	NNP
cord-006860-a3b8hyyr	4405	4	.	.	.
cord-006860-a3b8hyyr	4406	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	4406	2	activation	activation	NN
cord-006860-a3b8hyyr	4406	3	was	be	VBD
cord-006860-a3b8hyyr	4406	4	investigated	investigate	VBN
cord-006860-a3b8hyyr	4406	5	using	use	VBG
cord-006860-a3b8hyyr	4406	6	gtycoprotein	gtycoprotein	NNP
cord-006860-a3b8hyyr	4406	7	ffla	ffla	NNP
cord-006860-a3b8hyyr	4406	8	and	and	CC
cord-006860-a3b8hyyr	4406	9	GMP	GMP	NNP
cord-006860-a3b8hyyr	4406	10	140	140	CD
cord-006860-a3b8hyyr	4406	11	specific	specific	JJ
cord-006860-a3b8hyyr	4406	12	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4406	13	on	on	IN
cord-006860-a3b8hyyr	4406	14	a	a	DT
cord-006860-a3b8hyyr	4406	15	flow	flow	NN
cord-006860-a3b8hyyr	4406	16	cytometer	cytometer	NN
cord-006860-a3b8hyyr	4406	17	(	(	-LRB-
cord-006860-a3b8hyyr	4406	18	Epic	Epic	NNP
cord-006860-a3b8hyyr	4406	19	Coulter	Coulter	NNP
cord-006860-a3b8hyyr	4406	20	)	)	-RRB-
cord-006860-a3b8hyyr	4406	21	.	.	.
cord-006860-a3b8hyyr	4407	1	Tissue	tissue	NN
cord-006860-a3b8hyyr	4407	2	factor	factor	NN
cord-006860-a3b8hyyr	4407	3	was	be	VBD
cord-006860-a3b8hyyr	4407	4	found	find	VBN
cord-006860-a3b8hyyr	4407	5	to	to	TO
cord-006860-a3b8hyyr	4407	6	produce	produce	VB
cord-006860-a3b8hyyr	4407	7	the	the	DT
cord-006860-a3b8hyyr	4407	8	activation	activation	NN
cord-006860-a3b8hyyr	4407	9	of	of	IN
cord-006860-a3b8hyyr	4407	10	both	both	CC
cord-006860-a3b8hyyr	4407	11	the	the	DT
cord-006860-a3b8hyyr	4407	12	baseline	baseline	NN
cord-006860-a3b8hyyr	4407	13	and	and	CC
cord-006860-a3b8hyyr	4407	14	asp	asp	NNP
cord-006860-a3b8hyyr	4407	15	'	'	''
cord-006860-a3b8hyyr	4407	16	"	"	``
cord-006860-a3b8hyyr	4407	17	mnized	mnize	VBN
cord-006860-a3b8hyyr	4407	18	platelets	platelet	NNS
cord-006860-a3b8hyyr	4407	19	.	.	.
cord-006860-a3b8hyyr	4408	1	Aprotinirt	Aprotinirt	NNP
cord-006860-a3b8hyyr	4408	2	augmented	augment	VBD
cord-006860-a3b8hyyr	4408	3	the	the	DT
cord-006860-a3b8hyyr	4408	4	tissue	tissue	NN
cord-006860-a3b8hyyr	4408	5	factor	factor	NN
cord-006860-a3b8hyyr	4408	6	activation	activation	NN
cord-006860-a3b8hyyr	4408	7	of	of	IN
cord-006860-a3b8hyyr	4408	8	platelets	platelet	NNS
cord-006860-a3b8hyyr	4408	9	in	in	IN
cord-006860-a3b8hyyr	4408	10	both	both	CC
cord-006860-a3b8hyyr	4408	11	the	the	DT
cord-006860-a3b8hyyr	4408	12	control	control	NN
cord-006860-a3b8hyyr	4408	13	and	and	CC
cord-006860-a3b8hyyr	4408	14	aspirin	aspirin	NN
cord-006860-a3b8hyyr	4408	15	supplemented	supplement	VBD
cord-006860-a3b8hyyr	4408	16	groups	group	NNS
cord-006860-a3b8hyyr	4408	17	.	.	.
cord-006860-a3b8hyyr	4409	1	However	however	RB
cord-006860-a3b8hyyr	4409	2	,	,	,
cord-006860-a3b8hyyr	4409	3	the	the	DT
cord-006860-a3b8hyyr	4409	4	relative	relative	JJ
cord-006860-a3b8hyyr	4409	5	increase	increase	NN
cord-006860-a3b8hyyr	4409	6	in	in	IN
cord-006860-a3b8hyyr	4409	7	the	the	DT
cord-006860-a3b8hyyr	4409	8	aspifinized	aspifinize	VBN
cord-006860-a3b8hyyr	4409	9	group	group	NN
cord-006860-a3b8hyyr	4409	10	was	be	VBD
cord-006860-a3b8hyyr	4409	11	much	much	JJ
cord-006860-a3b8hyyr	4409	12	monger	monger	NN
cord-006860-a3b8hyyr	4409	13	(	(	-LRB-
cord-006860-a3b8hyyr	4409	14	25	25	CD
cord-006860-a3b8hyyr	4409	15	%	%	NN
cord-006860-a3b8hyyr	4409	16	of	of	IN
cord-006860-a3b8hyyr	4409	17	the	the	DT
cord-006860-a3b8hyyr	4409	18	baseline	baseline	NN
cord-006860-a3b8hyyr	4409	19	)	)	-RRB-
cord-006860-a3b8hyyr	4409	20	.	.	.
cord-006860-a3b8hyyr	4410	1	These	these	DT
cord-006860-a3b8hyyr	4410	2	results	result	NNS
cord-006860-a3b8hyyr	4410	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	4410	4	that	that	IN
cord-006860-a3b8hyyr	4410	5	aprotinin	aprotinin	NNP
cord-006860-a3b8hyyr	4410	6	augments	augment	VBZ
cord-006860-a3b8hyyr	4410	7	the	the	DT
cord-006860-a3b8hyyr	4410	8	tissue	tissue	NN
cord-006860-a3b8hyyr	4410	9	factor	factor	NN
cord-006860-a3b8hyyr	4410	10	mediated	mediate	VBN
cord-006860-a3b8hyyr	4410	11	activation	activation	NN
cord-006860-a3b8hyyr	4410	12	of	of	IN
cord-006860-a3b8hyyr	4410	13	platelets	platelet	NNS
cord-006860-a3b8hyyr	4410	14	in	in	IN
cord-006860-a3b8hyyr	4410	15	both	both	CC
cord-006860-a3b8hyyr	4410	16	the	the	DT
cord-006860-a3b8hyyr	4410	17	normal	normal	JJ
cord-006860-a3b8hyyr	4410	18	and	and	CC
cord-006860-a3b8hyyr	4410	19	aspirinized	aspirinize	VBN
cord-006860-a3b8hyyr	4410	20	individuals	individual	NNS
cord-006860-a3b8hyyr	4410	21	.	.	.
cord-006860-a3b8hyyr	4411	1	While	while	IN
cord-006860-a3b8hyyr	4411	2	these	these	DT
cord-006860-a3b8hyyr	4411	3	effects	effect	NNS
cord-006860-a3b8hyyr	4411	4	may	may	MD
cord-006860-a3b8hyyr	4411	5	result	result	VB
cord-006860-a3b8hyyr	4411	6	in	in	IN
cord-006860-a3b8hyyr	4411	7	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	4411	8	restoration	restoration	NN
cord-006860-a3b8hyyr	4411	9	in	in	IN
cord-006860-a3b8hyyr	4411	10	aspirin	aspirin	NN
cord-006860-a3b8hyyr	4411	11	compromised	compromise	VBN
cord-006860-a3b8hyyr	4411	12	patients	patient	NNS
cord-006860-a3b8hyyr	4411	13	,	,	,
cord-006860-a3b8hyyr	4411	14	in	in	IN
cord-006860-a3b8hyyr	4411	15	normal	normal	JJ
cord-006860-a3b8hyyr	4411	16	individuals	individual	NNS
cord-006860-a3b8hyyr	4411	17	the	the	DT
cord-006860-a3b8hyyr	4411	18	clinical	clinical	JJ
cord-006860-a3b8hyyr	4411	19	implications	implication	NNS
cord-006860-a3b8hyyr	4411	20	of	of	IN
cord-006860-a3b8hyyr	4411	21	this	this	DT
cord-006860-a3b8hyyr	4411	22	effect	effect	NN
cord-006860-a3b8hyyr	4411	23	remain	remain	VBP
cord-006860-a3b8hyyr	4411	24	to	to	TO
cord-006860-a3b8hyyr	4411	25	be	be	VB
cord-006860-a3b8hyyr	4411	26	clarified	clarify	VBN
cord-006860-a3b8hyyr	4411	27	.	.	.
cord-006860-a3b8hyyr	4412	1	,	,	,
cord-006860-a3b8hyyr	4412	2	10	10	CD
cord-006860-a3b8hyyr	4412	3	-	-	SYM
cord-006860-a3b8hyyr	4412	4	20	20	CD
cord-006860-a3b8hyyr	4412	5	(	(	-LRB-
cord-006860-a3b8hyyr	4412	6	group	group	NN
cord-006860-a3b8hyyr	4412	7	2	2	CD
cord-006860-a3b8hyyr	4412	8	)	)	-RRB-
cord-006860-a3b8hyyr	4412	9	or	or	CC
cord-006860-a3b8hyyr	4412	10	>	>	XX
cord-006860-a3b8hyyr	4412	11	20	20	CD
cord-006860-a3b8hyyr	4412	12	years	year	NNS
cord-006860-a3b8hyyr	4412	13	(	(	-LRB-
cord-006860-a3b8hyyr	4412	14	group	group	NN
cord-006860-a3b8hyyr	4412	15	3	3	CD
cord-006860-a3b8hyyr	4412	16	)	)	-RRB-
cord-006860-a3b8hyyr	4412	17	duration	duration	NN
cord-006860-a3b8hyyr	4412	18	.	.	.
cord-006860-a3b8hyyr	4413	1	Anticoagulated	anticoagulated	JJ
cord-006860-a3b8hyyr	4413	2	whole	whole	JJ
cord-006860-a3b8hyyr	4413	3	blood	blood	NN
cord-006860-a3b8hyyr	4413	4	was	be	VBD
cord-006860-a3b8hyyr	4413	5	incubated	incubate	VBN
cord-006860-a3b8hyyr	4413	6	with	with	IN
cord-006860-a3b8hyyr	4413	7	fluorescent	fluorescent	JJ
cord-006860-a3b8hyyr	4413	8	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4413	9	to	to	IN
cord-006860-a3b8hyyr	4413	10	GPIb	GPIb	NNS
cord-006860-a3b8hyyr	4413	11	and	and	CC
cord-006860-a3b8hyyr	4413	12	GMP-140	GMP-140	NNP
cord-006860-a3b8hyyr	4413	13	(	(	-LRB-
cord-006860-a3b8hyyr	4413	14	two	two	CD
cord-006860-a3b8hyyr	4413	15	colour	colour	NN
cord-006860-a3b8hyyr	4413	16	method	method	NN
cord-006860-a3b8hyyr	4413	17	)	)	-RRB-
cord-006860-a3b8hyyr	4413	18	and	and	CC
cord-006860-a3b8hyyr	4413	19	analyzed	analyze	VBD
cord-006860-a3b8hyyr	4413	20	with	with	IN
cord-006860-a3b8hyyr	4413	21	a	a	DT
cord-006860-a3b8hyyr	4413	22	flow	flow	NN
cord-006860-a3b8hyyr	4413	23	cytometer	cytometer	NN
cord-006860-a3b8hyyr	4413	24	.	.	.
cord-006860-a3b8hyyr	4414	1	Thrombomodulin	Thrombomodulin	NNP
cord-006860-a3b8hyyr	4414	2	,	,	,
cord-006860-a3b8hyyr	4414	3	F1	F1	NNP
cord-006860-a3b8hyyr	4414	4	+	+	SYM
cord-006860-a3b8hyyr	4414	5	2	2	CD
cord-006860-a3b8hyyr	4414	6	,	,	,
cord-006860-a3b8hyyr	4414	7	protein	protein	NN
cord-006860-a3b8hyyr	4414	8	S	S	NNP
cord-006860-a3b8hyyr	4414	9	,	,	,
cord-006860-a3b8hyyr	4414	10	13-thromboglobulin	13-thromboglobulin	CD
cord-006860-a3b8hyyr	4414	11	were	be	VBD
cord-006860-a3b8hyyr	4414	12	measured	measure	VBN
cord-006860-a3b8hyyr	4414	13	according	accord	VBG
cord-006860-a3b8hyyr	4414	14	to	to	IN
cord-006860-a3b8hyyr	4414	15	standard	standard	JJ
cord-006860-a3b8hyyr	4414	16	procedures	procedure	NNS
cord-006860-a3b8hyyr	4414	17	.	.	.
cord-006860-a3b8hyyr	4415	1	RESULTS	result	NNS
cord-006860-a3b8hyyr	4415	2	:	:	:
cord-006860-a3b8hyyr	4416	1	Surface	surface	NN
cord-006860-a3b8hyyr	4416	2	expression	expression	NN
cord-006860-a3b8hyyr	4416	3	of	of	IN
cord-006860-a3b8hyyr	4416	4	GMP-140	GMP-140	NNP
cord-006860-a3b8hyyr	4416	5	was	be	VBD
cord-006860-a3b8hyyr	4416	6	not	not	RB
cord-006860-a3b8hyyr	4416	7	different	different	JJ
cord-006860-a3b8hyyr	4416	8	in	in	IN
cord-006860-a3b8hyyr	4416	9	groups	group	NNS
cord-006860-a3b8hyyr	4416	10	1	1	CD
cord-006860-a3b8hyyr	4416	11	to	to	IN
cord-006860-a3b8hyyr	4416	12	3	3	CD
cord-006860-a3b8hyyr	4416	13	,	,	,
cord-006860-a3b8hyyr	4416	14	however	however	RB
cord-006860-a3b8hyyr	4416	15	,	,	,
cord-006860-a3b8hyyr	4416	16	there	there	EX
cord-006860-a3b8hyyr	4416	17	was	be	VBD
cord-006860-a3b8hyyr	4416	18	a	a	DT
cord-006860-a3b8hyyr	4416	19	tendency	tendency	NN
cord-006860-a3b8hyyr	4416	20	to	to	IN
cord-006860-a3b8hyyr	4416	21	higher	high	JJR
cord-006860-a3b8hyyr	4416	22	acitvation	acitvation	NN
cord-006860-a3b8hyyr	4416	23	in	in	IN
cord-006860-a3b8hyyr	4416	24	group	group	NN
cord-006860-a3b8hyyr	4416	25	1	1	CD
cord-006860-a3b8hyyr	4416	26	(	(	-LRB-
cord-006860-a3b8hyyr	4416	27	<	<	NNP
cord-006860-a3b8hyyr	4416	28	10	10	CD
cord-006860-a3b8hyyr	4416	29	years	year	NNS
cord-006860-a3b8hyyr	4416	30	IDDM	IDDM	NNP
cord-006860-a3b8hyyr	4416	31	)	)	-RRB-
cord-006860-a3b8hyyr	4416	32	.	.	.
cord-006860-a3b8hyyr	4417	1	Results	result	NNS
cord-006860-a3b8hyyr	4417	2	for	for	IN
cord-006860-a3b8hyyr	4417	3	thrombomodulin	thrombomodulin	NNP
cord-006860-a3b8hyyr	4417	4	,	,	,
cord-006860-a3b8hyyr	4417	5	F1	F1	NNP
cord-006860-a3b8hyyr	4417	6	+	+	SYM
cord-006860-a3b8hyyr	4417	7	2	2	CD
cord-006860-a3b8hyyr	4417	8	,	,	,
cord-006860-a3b8hyyr	4417	9	protein	protein	NN
cord-006860-a3b8hyyr	4417	10	S	S	NNP
cord-006860-a3b8hyyr	4417	11	,	,	,
cord-006860-a3b8hyyr	4417	12	13-thromboglobulin	13-thromboglobulin	CD
cord-006860-a3b8hyyr	4417	13	will	will	MD
cord-006860-a3b8hyyr	4417	14	also	also	RB
cord-006860-a3b8hyyr	4417	15	be	be	VB
cord-006860-a3b8hyyr	4417	16	presented	present	VBN
cord-006860-a3b8hyyr	4417	17	.	.	.
cord-006860-a3b8hyyr	4418	1	CONCLUSION	conclusion	NN
cord-006860-a3b8hyyr	4418	2	:	:	:
cord-006860-a3b8hyyr	4419	1	Though	though	IN
cord-006860-a3b8hyyr	4419	2	it	-PRON-	PRP
cord-006860-a3b8hyyr	4419	3	did	do	VBD
cord-006860-a3b8hyyr	4419	4	not	not	RB
cord-006860-a3b8hyyr	4419	5	reach	reach	VB
cord-006860-a3b8hyyr	4419	6	statistical	statistical	JJ
cord-006860-a3b8hyyr	4419	7	significance	significance	NN
cord-006860-a3b8hyyr	4419	8	,	,	,
cord-006860-a3b8hyyr	4419	9	platelet	platelet	NN
cord-006860-a3b8hyyr	4419	10	acitvation	acitvation	NN
cord-006860-a3b8hyyr	4419	11	seems	seem	VBZ
cord-006860-a3b8hyyr	4419	12	to	to	TO
cord-006860-a3b8hyyr	4419	13	be	be	VB
cord-006860-a3b8hyyr	4419	14	more	more	RBR
cord-006860-a3b8hyyr	4419	15	important	important	JJ
cord-006860-a3b8hyyr	4419	16	during	during	IN
cord-006860-a3b8hyyr	4419	17	early	early	JJ
cord-006860-a3b8hyyr	4419	18	diabetes	diabetes	NN
cord-006860-a3b8hyyr	4419	19	.	.	.
cord-006860-a3b8hyyr	4420	1	This	this	DT
cord-006860-a3b8hyyr	4420	2	wilt	wilt	NN
cord-006860-a3b8hyyr	4420	3	be	be	VB
cord-006860-a3b8hyyr	4420	4	correlated	correlate	VBN
cord-006860-a3b8hyyr	4420	5	with	with	IN
cord-006860-a3b8hyyr	4420	6	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4420	7	and	and	CC
cord-006860-a3b8hyyr	4420	8	plasmatic	plasmatic	JJ
cord-006860-a3b8hyyr	4420	9	activation	activation	NN
cord-006860-a3b8hyyr	4420	10	markers	marker	NNS
cord-006860-a3b8hyyr	4420	11	.	.	.
cord-006860-a3b8hyyr	4421	1	In	in	IN
cord-006860-a3b8hyyr	4421	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4421	3	clinic	clinic	NN
cord-006860-a3b8hyyr	4421	4	four	four	CD
cord-006860-a3b8hyyr	4421	5	patients	patient	NNS
cord-006860-a3b8hyyr	4421	6	with	with	IN
cord-006860-a3b8hyyr	4421	7	HIV	HIV	NNP
cord-006860-a3b8hyyr	4421	8	-	-	HYPH
cord-006860-a3b8hyyr	4421	9	related	relate	VBN
cord-006860-a3b8hyyr	4421	10	thrombocytopenia	thrombocytopenia	NNS
cord-006860-a3b8hyyr	4421	11	were	be	VBD
cord-006860-a3b8hyyr	4421	12	treated	treat	VBN
cord-006860-a3b8hyyr	4421	13	with	with	IN
cord-006860-a3b8hyyr	4421	14	a	a	DT
cord-006860-a3b8hyyr	4421	15	lot	lot	NN
cord-006860-a3b8hyyr	4421	16	of	of	IN
cord-006860-a3b8hyyr	4421	17	Gammagard	Gammagard	NNP
cord-006860-a3b8hyyr	4421	18	(	(	-LRB-
cord-006860-a3b8hyyr	4421	19	93F21ABllF	93f21abllf	CD
cord-006860-a3b8hyyr	4421	20	)	)	-RRB-
cord-006860-a3b8hyyr	4421	21	,	,	,
cord-006860-a3b8hyyr	4421	22	which	which	WDT
cord-006860-a3b8hyyr	4421	23	later	later	RB
cord-006860-a3b8hyyr	4421	24	turned	turn	VBD
cord-006860-a3b8hyyr	4421	25	out	out	RP
cord-006860-a3b8hyyr	4421	26	to	to	TO
cord-006860-a3b8hyyr	4421	27	be	be	VB
cord-006860-a3b8hyyr	4421	28	HCV	HCV	NNP
cord-006860-a3b8hyyr	4421	29	contaminated	contaminate	VBN
cord-006860-a3b8hyyr	4421	30	.	.	.
cord-006860-a3b8hyyr	4422	1	Before	before	IN
cord-006860-a3b8hyyr	4422	2	infusion	infusion	NN
cord-006860-a3b8hyyr	4422	3	all	all	DT
cord-006860-a3b8hyyr	4422	4	patients	patient	NNS
cord-006860-a3b8hyyr	4422	5	were	be	VBD
cord-006860-a3b8hyyr	4422	6	negative	negative	JJ
cord-006860-a3b8hyyr	4422	7	for	for	IN
cord-006860-a3b8hyyr	4422	8	HCV	HCV	NNP
cord-006860-a3b8hyyr	4422	9	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4422	10	and	and	CC
cord-006860-a3b8hyyr	4422	11	HCV	HCV	NNP
cord-006860-a3b8hyyr	4422	12	RNA	RNA	NNP
cord-006860-a3b8hyyr	4422	13	.	.	.
cord-006860-a3b8hyyr	4423	1	2	2	CD
cord-006860-a3b8hyyr	4423	2	to	to	TO
cord-006860-a3b8hyyr	4423	3	8	8	CD
cord-006860-a3b8hyyr	4423	4	months	month	NNS
cord-006860-a3b8hyyr	4423	5	after	after	IN
cord-006860-a3b8hyyr	4423	6	infusion	infusion	NN
cord-006860-a3b8hyyr	4423	7	2/4	2/4	CD
cord-006860-a3b8hyyr	4423	8	patients	patient	NNS
cord-006860-a3b8hyyr	4423	9	,	,	,
cord-006860-a3b8hyyr	4423	10	who	who	WP
cord-006860-a3b8hyyr	4423	11	suffered	suffer	VBD
cord-006860-a3b8hyyr	4423	12	from	from	IN
cord-006860-a3b8hyyr	4423	13	ARC	ARC	NNP
cord-006860-a3b8hyyr	4423	14	at	at	IN
cord-006860-a3b8hyyr	4423	15	the	the	DT
cord-006860-a3b8hyyr	4423	16	time	time	NN
cord-006860-a3b8hyyr	4423	17	of	of	IN
cord-006860-a3b8hyyr	4423	18	HCV	HCV	NNP
cord-006860-a3b8hyyr	4423	19	infection	infection	NN
cord-006860-a3b8hyyr	4423	20	with	with	IN
cord-006860-a3b8hyyr	4423	21	CD4	CD4	NNP
cord-006860-a3b8hyyr	4423	22	counts	count	VBZ
cord-006860-a3b8hyyr	4424	1	>	>	XX
cord-006860-a3b8hyyr	4424	2	100	100	CD
cord-006860-a3b8hyyr	4424	3	/	/	SYM
cord-006860-a3b8hyyr	4424	4	pL	pl	XX
cord-006860-a3b8hyyr	4424	5	,	,	,
cord-006860-a3b8hyyr	4424	6	seroconverted	seroconverte	VBD
cord-006860-a3b8hyyr	4424	7	,	,	,
cord-006860-a3b8hyyr	4424	8	whereas	whereas	IN
cord-006860-a3b8hyyr	4424	9	in	in	IN
cord-006860-a3b8hyyr	4424	10	the	the	DT
cord-006860-a3b8hyyr	4424	11	two	two	CD
cord-006860-a3b8hyyr	4424	12	other	other	JJ
cord-006860-a3b8hyyr	4424	13	patients	patient	NNS
cord-006860-a3b8hyyr	4424	14	,	,	,
cord-006860-a3b8hyyr	4424	15	who	who	WP
cord-006860-a3b8hyyr	4424	16	suffered	suffer	VBD
cord-006860-a3b8hyyr	4424	17	from	from	IN
cord-006860-a3b8hyyr	4424	18	AIDS	AIDS	NNP
cord-006860-a3b8hyyr	4424	19	with	with	IN
cord-006860-a3b8hyyr	4424	20	CD4	CD4	NNP
cord-006860-a3b8hyyr	4424	21	counts	count	VBZ
cord-006860-a3b8hyyr	4424	22	below	below	IN
cord-006860-a3b8hyyr	4424	23	100	100	CD
cord-006860-a3b8hyyr	4424	24	/	/	SYM
cord-006860-a3b8hyyr	4424	25	pl	pl	XX
cord-006860-a3b8hyyr	4424	26	,	,	,
cord-006860-a3b8hyyr	4424	27	there	there	EX
cord-006860-a3b8hyyr	4424	28	was	be	VBD
cord-006860-a3b8hyyr	4424	29	no	no	DT
cord-006860-a3b8hyyr	4424	30	seroconversion	seroconversion	NN
cord-006860-a3b8hyyr	4424	31	.	.	.
cord-006860-a3b8hyyr	4425	1	In	in	IN
cord-006860-a3b8hyyr	4425	2	all	all	DT
cord-006860-a3b8hyyr	4425	3	cases	case	NNS
cord-006860-a3b8hyyr	4425	4	HCV	HCV	NNP
cord-006860-a3b8hyyr	4425	5	RNA	RNA	NNP
cord-006860-a3b8hyyr	4425	6	was	be	VBD
cord-006860-a3b8hyyr	4425	7	found	find	VBN
cord-006860-a3b8hyyr	4425	8	.	.	.
cord-006860-a3b8hyyr	4426	1	Genotyping	genotype	VBG
cord-006860-a3b8hyyr	4426	2	with	with	IN
cord-006860-a3b8hyyr	4426	3	Inno	Inno	NNP
cord-006860-a3b8hyyr	4426	4	-	-	HYPH
cord-006860-a3b8hyyr	4426	5	LIPA	LIPA	NNP
cord-006860-a3b8hyyr	4426	6	(	(	-LRB-
cord-006860-a3b8hyyr	4426	7	Innogenetice	Innogenetice	NNP
cord-006860-a3b8hyyr	4426	8	)	)	-RRB-
cord-006860-a3b8hyyr	4426	9	showed	show	VBD
cord-006860-a3b8hyyr	4426	10	HCV	HCV	NNP
cord-006860-a3b8hyyr	4426	11	genotype	genotype	NN
cord-006860-a3b8hyyr	4426	12	l(b	l(b	NNP
cord-006860-a3b8hyyr	4426	13	)	)	-RRB-
cord-006860-a3b8hyyr	4426	14	in	in	IN
cord-006860-a3b8hyyr	4426	15	all	all	DT
cord-006860-a3b8hyyr	4426	16	patients	patient	NNS
cord-006860-a3b8hyyr	4426	17	.	.	.
cord-006860-a3b8hyyr	4427	1	Liver	liver	NN
cord-006860-a3b8hyyr	4427	2	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	4427	3	and	and	CC
cord-006860-a3b8hyyr	4427	4	HCV	HCV	NNP
cord-006860-a3b8hyyr	4427	5	RNA	RNA	NNP
cord-006860-a3b8hyyr	4427	6	copies	copy	NNS
cord-006860-a3b8hyyr	4427	7	were	be	VBD
cord-006860-a3b8hyyr	4427	8	measured	measure	VBN
cord-006860-a3b8hyyr	4427	9	repeatedly	repeatedly	RB
cord-006860-a3b8hyyr	4427	10	over	over	IN
cord-006860-a3b8hyyr	4427	11	a	a	DT
cord-006860-a3b8hyyr	4427	12	period	period	NN
cord-006860-a3b8hyyr	4427	13	of	of	IN
cord-006860-a3b8hyyr	4427	14	one	one	CD
cord-006860-a3b8hyyr	4427	15	year	year	NN
cord-006860-a3b8hyyr	4427	16	after	after	IN
cord-006860-a3b8hyyr	4427	17	infection	infection	NN
cord-006860-a3b8hyyr	4427	18	.	.	.
cord-006860-a3b8hyyr	4428	1	The	the	DT
cord-006860-a3b8hyyr	4428	2	2	2	CD
cord-006860-a3b8hyyr	4428	3	patients	patient	NNS
cord-006860-a3b8hyyr	4428	4	with	with	IN
cord-006860-a3b8hyyr	4428	5	ARC	ARC	NNP
cord-006860-a3b8hyyr	4428	6	showed	show	VBD
cord-006860-a3b8hyyr	4428	7	a	a	DT
cord-006860-a3b8hyyr	4428	8	strong	strong	JJ
cord-006860-a3b8hyyr	4428	9	increase	increase	NN
cord-006860-a3b8hyyr	4428	10	of	of	IN
cord-006860-a3b8hyyr	4428	11	HCV	HCV	NNP
cord-006860-a3b8hyyr	4428	12	RNA	RNA	NNP
cord-006860-a3b8hyyr	4428	13	titre	titre	NN
cord-006860-a3b8hyyr	4428	14	during	during	IN
cord-006860-a3b8hyyr	4428	15	the	the	DT
cord-006860-a3b8hyyr	4428	16	first	first	JJ
cord-006860-a3b8hyyr	4428	17	3	3	CD
cord-006860-a3b8hyyr	4428	18	to	to	TO
cord-006860-a3b8hyyr	4428	19	4	4	CD
cord-006860-a3b8hyyr	4428	20	months	month	NNS
cord-006860-a3b8hyyr	4428	21	after	after	IN
cord-006860-a3b8hyyr	4428	22	infection	infection	NN
cord-006860-a3b8hyyr	4428	23	,	,	,
cord-006860-a3b8hyyr	4428	24	followed	follow	VBN
cord-006860-a3b8hyyr	4428	25	by	by	IN
cord-006860-a3b8hyyr	4428	26	a	a	DT
cord-006860-a3b8hyyr	4428	27	rapid	rapid	JJ
cord-006860-a3b8hyyr	4428	28	decrease	decrease	NN
cord-006860-a3b8hyyr	4428	29	within	within	IN
cord-006860-a3b8hyyr	4428	30	the	the	DT
cord-006860-a3b8hyyr	4428	31	next	next	JJ
cord-006860-a3b8hyyr	4428	32	months	month	NNS
cord-006860-a3b8hyyr	4428	33	.	.	.
cord-006860-a3b8hyyr	4429	1	In	in	IN
cord-006860-a3b8hyyr	4429	2	the	the	DT
cord-006860-a3b8hyyr	4429	3	patients	patient	NNS
cord-006860-a3b8hyyr	4429	4	with	with	IN
cord-006860-a3b8hyyr	4429	5	AIDS	AIDS	NNP
cord-006860-a3b8hyyr	4429	6	HCV	HCV	NNP
cord-006860-a3b8hyyr	4429	7	RNA	RNA	NNP
cord-006860-a3b8hyyr	4429	8	copies	copy	NNS
cord-006860-a3b8hyyr	4429	9	increased	increase	VBD
cord-006860-a3b8hyyr	4429	10	moderately	moderately	RB
cord-006860-a3b8hyyr	4429	11	within	within	IN
cord-006860-a3b8hyyr	4429	12	the	the	DT
cord-006860-a3b8hyyr	4429	13	first	first	JJ
cord-006860-a3b8hyyr	4429	14	4	4	CD
cord-006860-a3b8hyyr	4429	15	to	to	TO
cord-006860-a3b8hyyr	4429	16	6	6	CD
cord-006860-a3b8hyyr	4429	17	months	month	NNS
cord-006860-a3b8hyyr	4429	18	,	,	,
cord-006860-a3b8hyyr	4429	19	followed	follow	VBN
cord-006860-a3b8hyyr	4429	20	by	by	IN
cord-006860-a3b8hyyr	4429	21	a	a	DT
cord-006860-a3b8hyyr	4429	22	slow	slow	JJ
cord-006860-a3b8hyyr	4429	23	decrease	decrease	NN
cord-006860-a3b8hyyr	4429	24	.	.	.
cord-006860-a3b8hyyr	4430	1	Elevation	elevation	NN
cord-006860-a3b8hyyr	4430	2	of	of	IN
cord-006860-a3b8hyyr	4430	3	liver	liver	NN
cord-006860-a3b8hyyr	4430	4	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	4430	5	was	be	VBD
cord-006860-a3b8hyyr	4430	6	mild	mild	JJ
cord-006860-a3b8hyyr	4430	7	in	in	IN
cord-006860-a3b8hyyr	4430	8	the	the	DT
cord-006860-a3b8hyyr	4430	9	AIDS	AIDS	NNP
cord-006860-a3b8hyyr	4430	10	patients	patient	NNS
cord-006860-a3b8hyyr	4430	11	and	and	CC
cord-006860-a3b8hyyr	4430	12	seems	seem	VBZ
cord-006860-a3b8hyyr	4430	13	to	to	TO
cord-006860-a3b8hyyr	4430	14	be	be	VB
cord-006860-a3b8hyyr	4430	15	independent	independent	JJ
cord-006860-a3b8hyyr	4430	16	from	from	IN
cord-006860-a3b8hyyr	4430	17	the	the	DT
cord-006860-a3b8hyyr	4430	18	HCV	HCV	NNP
cord-006860-a3b8hyyr	4430	19	RNA	RNA	NNP
cord-006860-a3b8hyyr	4430	20	titre	titre	NN
cord-006860-a3b8hyyr	4430	21	.	.	.
cord-006860-a3b8hyyr	4431	1	In	in	IN
cord-006860-a3b8hyyr	4431	2	the	the	DT
cord-006860-a3b8hyyr	4431	3	ARC	ARC	NNP
cord-006860-a3b8hyyr	4431	4	patients	patient	NNS
cord-006860-a3b8hyyr	4431	5	liver	liver	NN
cord-006860-a3b8hyyr	4431	6	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	4431	7	changed	change	VBD
cord-006860-a3b8hyyr	4431	8	parallel	parallel	NN
cord-006860-a3b8hyyr	4431	9	to	to	IN
cord-006860-a3b8hyyr	4431	10	HCV	HCV	NNP
cord-006860-a3b8hyyr	4431	11	RNA	RNA	NNP
cord-006860-a3b8hyyr	4431	12	titers	titer	NNS
cord-006860-a3b8hyyr	4431	13	with	with	IN
cord-006860-a3b8hyyr	4431	14	a	a	DT
cord-006860-a3b8hyyr	4431	15	delay	delay	NN
cord-006860-a3b8hyyr	4431	16	of	of	IN
cord-006860-a3b8hyyr	4431	17	2	2	CD
cord-006860-a3b8hyyr	4431	18	to	to	TO
cord-006860-a3b8hyyr	4431	19	3	3	CD
cord-006860-a3b8hyyr	4431	20	months	month	NNS
cord-006860-a3b8hyyr	4431	21	.	.	.
cord-006860-a3b8hyyr	4432	1	The	the	DT
cord-006860-a3b8hyyr	4432	2	course	course	NN
cord-006860-a3b8hyyr	4432	3	of	of	IN
cord-006860-a3b8hyyr	4432	4	HIV	HIV	NNP
cord-006860-a3b8hyyr	4432	5	infection	infection	NN
cord-006860-a3b8hyyr	4432	6	was	be	VBD
cord-006860-a3b8hyyr	4432	7	only	only	RB
cord-006860-a3b8hyyr	4432	8	slightly	slightly	RB
cord-006860-a3b8hyyr	4432	9	influenced	influence	VBN
cord-006860-a3b8hyyr	4432	10	by	by	IN
cord-006860-a3b8hyyr	4432	11	the	the	DT
cord-006860-a3b8hyyr	4432	12	acute	acute	JJ
cord-006860-a3b8hyyr	4432	13	hepatitis	hepatitis	NN
cord-006860-a3b8hyyr	4432	14	C	C	NNP
cord-006860-a3b8hyyr	4432	15	as	as	IN
cord-006860-a3b8hyyr	4432	16	measured	measure	VBN
cord-006860-a3b8hyyr	4432	17	by	by	IN
cord-006860-a3b8hyyr	4432	18	CD4	CD4	NNP
cord-006860-a3b8hyyr	4432	19	counts	count	VBZ
cord-006860-a3b8hyyr	4432	20	,	,	,
cord-006860-a3b8hyyr	4432	21	i%2microglobulin	i%2microglobulin	NNP
cord-006860-a3b8hyyr	4432	22	and	and	CC
cord-006860-a3b8hyyr	4432	23	HIV	HIV	NNP
cord-006860-a3b8hyyr	4432	24	RNA	RNA	NNP
cord-006860-a3b8hyyr	4432	25	copies	copy	NNS
cord-006860-a3b8hyyr	4432	26	.	.	.
cord-006860-a3b8hyyr	4433	1	Introduction	introduction	NN
cord-006860-a3b8hyyr	4433	2	:	:	:
cord-006860-a3b8hyyr	4434	1	Mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	4434	2	underlying	underlie	VBG
cord-006860-a3b8hyyr	4434	3	ischemia	ischemia	NN
cord-006860-a3b8hyyr	4434	4	/	/	SYM
cord-006860-a3b8hyyr	4434	5	reperfusion	reperfusion	NN
cord-006860-a3b8hyyr	4434	6	injury	injury	NN
cord-006860-a3b8hyyr	4434	7	have	have	VBP
cord-006860-a3b8hyyr	4434	8	been	be	VBN
cord-006860-a3b8hyyr	4434	9	thoumughly	thoumughly	NNP
cord-006860-a3b8hyyr	4434	10	investigated	investigate	VBN
cord-006860-a3b8hyyr	4434	11	in	in	IN
cord-006860-a3b8hyyr	4434	12	experimental	experimental	JJ
cord-006860-a3b8hyyr	4434	13	models	model	NNS
cord-006860-a3b8hyyr	4434	14	.	.	.
cord-006860-a3b8hyyr	4435	1	Leucocytes	leucocyte	NNS
cord-006860-a3b8hyyr	4435	2	appear	appear	VBP
cord-006860-a3b8hyyr	4435	3	to	to	TO
cord-006860-a3b8hyyr	4435	4	play	play	VB
cord-006860-a3b8hyyr	4435	5	a	a	DT
cord-006860-a3b8hyyr	4435	6	main	main	JJ
cord-006860-a3b8hyyr	4435	7	role	role	NN
cord-006860-a3b8hyyr	4435	8	through	through	IN
cord-006860-a3b8hyyr	4435	9	production	production	NN
cord-006860-a3b8hyyr	4435	10	of	of	IN
cord-006860-a3b8hyyr	4435	11	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	4435	12	and	and	CC
cord-006860-a3b8hyyr	4435	13	overexpresssion	overexpresssion	NN
cord-006860-a3b8hyyr	4435	14	of	of	IN
cord-006860-a3b8hyyr	4435	15	adhesion	adhesion	NN
cord-006860-a3b8hyyr	4435	16	molecules	molecule	NNS
cord-006860-a3b8hyyr	4435	17	.	.	.
cord-006860-a3b8hyyr	4436	1	In	in	IN
cord-006860-a3b8hyyr	4436	2	experimental	experimental	JJ
cord-006860-a3b8hyyr	4436	3	animals	animal	NNS
cord-006860-a3b8hyyr	4436	4	,	,	,
cord-006860-a3b8hyyr	4436	5	administration	administration	NN
cord-006860-a3b8hyyr	4436	6	of	of	IN
cord-006860-a3b8hyyr	4436	7	monocional	monocional	NNP
cord-006860-a3b8hyyr	4436	8	antibodies	antibodies	NNP
cord-006860-a3b8hyyr	4436	9	(	(	-LRB-
cord-006860-a3b8hyyr	4436	10	MAb	MAb	NNS
cord-006860-a3b8hyyr	4436	11	)	)	-RRB-
cord-006860-a3b8hyyr	4436	12	recognizing	recognize	VBG
cord-006860-a3b8hyyr	4436	13	CD18	CD18	NNP
cord-006860-a3b8hyyr	4436	14	can	can	MD
cord-006860-a3b8hyyr	4436	15	reduce	reduce	VB
cord-006860-a3b8hyyr	4436	16	organ	organ	NN
cord-006860-a3b8hyyr	4436	17	injury	injury	NN
cord-006860-a3b8hyyr	4436	18	following	follow	VBG
cord-006860-a3b8hyyr	4436	19	ischemia	ischemia	NN
cord-006860-a3b8hyyr	4436	20	/	/	SYM
cord-006860-a3b8hyyr	4436	21	repedusion	repedusion	NN
cord-006860-a3b8hyyr	4436	22	.	.	.
cord-006860-a3b8hyyr	4437	1	No	no	DT
cord-006860-a3b8hyyr	4437	2	data	datum	NNS
cord-006860-a3b8hyyr	4437	3	,	,	,
cord-006860-a3b8hyyr	4437	4	however	however	RB
cord-006860-a3b8hyyr	4437	5	,	,	,
cord-006860-a3b8hyyr	4437	6	have	have	VBP
cord-006860-a3b8hyyr	4437	7	been	be	VBN
cord-006860-a3b8hyyr	4437	8	reported	report	VBN
cord-006860-a3b8hyyr	4437	9	concerning	concern	VBG
cord-006860-a3b8hyyr	4437	10	clinical	clinical	JJ
cord-006860-a3b8hyyr	4437	11	ischemia	ischemia	NN
cord-006860-a3b8hyyr	4437	12	situations	situation	NNS
cord-006860-a3b8hyyr	4437	13	.	.	.
cord-006860-a3b8hyyr	4438	1	Patients	patient	NNS
cord-006860-a3b8hyyr	4438	2	and	and	CC
cord-006860-a3b8hyyr	4438	3	Methods	method	NNS
cord-006860-a3b8hyyr	4439	1	:	:	:
cord-006860-a3b8hyyr	4439	2	We	-PRON-	PRP
cord-006860-a3b8hyyr	4439	3	investigated	investigate	VBD
cord-006860-a3b8hyyr	4439	4	expression	expression	NN
cord-006860-a3b8hyyr	4439	5	of	of	IN
cord-006860-a3b8hyyr	4439	6	CDt8	CDt8	NNP
cord-006860-a3b8hyyr	4439	7	,	,	,
cord-006860-a3b8hyyr	4439	8	CD1	CD1	NNP
cord-006860-a3b8hyyr	4439	9	la	la	NNP
cord-006860-a3b8hyyr	4439	10	,	,	,
cord-006860-a3b8hyyr	4439	11	CDf	CDf	NNP
cord-006860-a3b8hyyr	4439	12	l	l	NNP
cord-006860-a3b8hyyr	4439	13	b	b	NNP
cord-006860-a3b8hyyr	4439	14	and	and	CC
cord-006860-a3b8hyyr	4439	15	CD1	CD1	NNP
cord-006860-a3b8hyyr	4439	16	lc	lc	NNP
cord-006860-a3b8hyyr	4439	17	in	in	IN
cord-006860-a3b8hyyr	4439	18	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4439	19	,	,	,
cord-006860-a3b8hyyr	4439	20	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	4439	21	and	and	CC
cord-006860-a3b8hyyr	4439	22	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	4439	23	from	from	IN
cord-006860-a3b8hyyr	4439	24	peripheral	peripheral	JJ
cord-006860-a3b8hyyr	4439	25	blood	blood	NN
cord-006860-a3b8hyyr	4439	26	of	of	IN
cord-006860-a3b8hyyr	4439	27	five	five	CD
cord-006860-a3b8hyyr	4439	28	patients	patient	NNS
cord-006860-a3b8hyyr	4439	29	undergoing	undergo	VBG
cord-006860-a3b8hyyr	4439	30	elective	elective	JJ
cord-006860-a3b8hyyr	4439	31	hand	hand	NN
cord-006860-a3b8hyyr	4439	32	surgery	surgery	NN
cord-006860-a3b8hyyr	4439	33	.	.	.
cord-006860-a3b8hyyr	4440	1	The	the	DT
cord-006860-a3b8hyyr	4440	2	tourniquet	tourniquet	NN
cord-006860-a3b8hyyr	4440	3	was	be	VBD
cord-006860-a3b8hyyr	4440	4	applied	apply	VBN
cord-006860-a3b8hyyr	4440	5	on	on	IN
cord-006860-a3b8hyyr	4440	6	the	the	DT
cord-006860-a3b8hyyr	4440	7	upper	upper	JJ
cord-006860-a3b8hyyr	4440	8	arm	arm	NN
cord-006860-a3b8hyyr	4440	9	and	and	CC
cord-006860-a3b8hyyr	4440	10	heparinized	heparinize	VBD
cord-006860-a3b8hyyr	4440	11	samples	sample	NNS
cord-006860-a3b8hyyr	4440	12	from	from	IN
cord-006860-a3b8hyyr	4440	13	cubital	cubital	JJ
cord-006860-a3b8hyyr	4440	14	veins	vein	NNS
cord-006860-a3b8hyyr	4440	15	were	be	VBD
cord-006860-a3b8hyyr	4440	16	obtained	obtain	VBN
cord-006860-a3b8hyyr	4440	17	before	before	RB
cord-006860-a3b8hyyr	4440	18	and	and	CC
cord-006860-a3b8hyyr	4440	19	at	at	IN
cord-006860-a3b8hyyr	4440	20	the	the	DT
cord-006860-a3b8hyyr	4440	21	end	end	NN
cord-006860-a3b8hyyr	4440	22	of	of	IN
cord-006860-a3b8hyyr	4440	23	ischemia	ischemia	NN
cord-006860-a3b8hyyr	4440	24	.	.	.
cord-006860-a3b8hyyr	4441	1	Control	control	NN
cord-006860-a3b8hyyr	4441	2	samples	sample	NNS
cord-006860-a3b8hyyr	4441	3	were	be	VBD
cord-006860-a3b8hyyr	4441	4	drawn	draw	VBN
cord-006860-a3b8hyyr	4441	5	from	from	IN
cord-006860-a3b8hyyr	4441	6	the	the	DT
cord-006860-a3b8hyyr	4441	7	nonischemic	nonischemic	NNP
cord-006860-a3b8hyyr	4441	8	contralataral	contralataral	NNP
cord-006860-a3b8hyyr	4441	9	arm	arm	NN
cord-006860-a3b8hyyr	4441	10	with	with	IN
cord-006860-a3b8hyyr	4441	11	the	the	DT
cord-006860-a3b8hyyr	4441	12	same	same	JJ
cord-006860-a3b8hyyr	4441	13	timing	timing	NN
cord-006860-a3b8hyyr	4441	14	,	,	,
cord-006860-a3b8hyyr	4441	15	Duration	duration	NN
cord-006860-a3b8hyyr	4441	16	ot	ot	IN
cord-006860-a3b8hyyr	4441	17	ischemia	ischemia	NN
cord-006860-a3b8hyyr	4441	18	ranged	range	VBD
cord-006860-a3b8hyyr	4441	19	between	between	IN
cord-006860-a3b8hyyr	4441	20	sixty	sixty	CD
cord-006860-a3b8hyyr	4441	21	and	and	CC
cord-006860-a3b8hyyr	4441	22	one	one	CD
cord-006860-a3b8hyyr	4441	23	hundred	hundred	CD
cord-006860-a3b8hyyr	4441	24	minutes	minute	NNS
cord-006860-a3b8hyyr	4441	25	(	(	-LRB-
cord-006860-a3b8hyyr	4441	26	80~16	80~16	CD
cord-006860-a3b8hyyr	4441	27	)	)	-RRB-
cord-006860-a3b8hyyr	4441	28	.	.	.
cord-006860-a3b8hyyr	4442	1	Whole	whole	JJ
cord-006860-a3b8hyyr	4442	2	blood	blood	NN
cord-006860-a3b8hyyr	4442	3	samples	sample	NNS
cord-006860-a3b8hyyr	4442	4	were	be	VBD
cord-006860-a3b8hyyr	4442	5	incubated	incubate	VBN
cord-006860-a3b8hyyr	4442	6	with	with	IN
cord-006860-a3b8hyyr	4442	7	specific	specific	JJ
cord-006860-a3b8hyyr	4442	8	,	,	,
cord-006860-a3b8hyyr	4442	9	fluorochmme	fluorochmme	JJ
cord-006860-a3b8hyyr	4442	10	labelled	label	VBN
cord-006860-a3b8hyyr	4442	11	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4442	12	and	and	CC
cord-006860-a3b8hyyr	4442	13	analyzed	analyze	VBN
cord-006860-a3b8hyyr	4442	14	by	by	IN
cord-006860-a3b8hyyr	4442	15	fluorocytometry	fluorocytometry	NNP
cord-006860-a3b8hyyr	4442	16	(	(	-LRB-
cord-006860-a3b8hyyr	4442	17	FACScan	facscan	NN
cord-006860-a3b8hyyr	4442	18	,	,	,
cord-006860-a3b8hyyr	4442	19	Becton	Becton	NNP
cord-006860-a3b8hyyr	4442	20	Dickinson	Dickinson	NNP
cord-006860-a3b8hyyr	4442	21	,	,	,
cord-006860-a3b8hyyr	4442	22	San	San	NNP
cord-006860-a3b8hyyr	4442	23	Jose	Jose	NNP
cord-006860-a3b8hyyr	4442	24	,	,	,
cord-006860-a3b8hyyr	4442	25	CA	CA	NNP
cord-006860-a3b8hyyr	4442	26	)	)	-RRB-
cord-006860-a3b8hyyr	4442	27	.	.	.
cord-006860-a3b8hyyr	4443	1	Mean	mean	JJ
cord-006860-a3b8hyyr	4443	2	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	4443	3	intensity	intensity	NN
cord-006860-a3b8hyyr	4443	4	(	(	-LRB-
cord-006860-a3b8hyyr	4443	5	MFI	MFI	NNP
cord-006860-a3b8hyyr	4443	6	)	)	-RRB-
cord-006860-a3b8hyyr	4443	7	,	,	,
cord-006860-a3b8hyyr	4443	8	quantitatively	quantitatively	RB
cord-006860-a3b8hyyr	4443	9	reflecting	reflect	VBG
cord-006860-a3b8hyyr	4443	10	surface	surface	NN
cord-006860-a3b8hyyr	4443	11	expression	expression	NN
cord-006860-a3b8hyyr	4443	12	of	of	IN
cord-006860-a3b8hyyr	4443	13	the	the	DT
cord-006860-a3b8hyyr	4443	14	indicated	indicate	VBN
cord-006860-a3b8hyyr	4443	15	markers	marker	NNS
cord-006860-a3b8hyyr	4443	16	was	be	VBD
cord-006860-a3b8hyyr	4443	17	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	4443	18	for	for	IN
cord-006860-a3b8hyyr	4443	19	the	the	DT
cord-006860-a3b8hyyr	4443	20	individual	individual	JJ
cord-006860-a3b8hyyr	4443	21	cell	cell	NN
cord-006860-a3b8hyyr	4443	22	populations	population	NNS
cord-006860-a3b8hyyr	4443	23	.	.	.
cord-006860-a3b8hyyr	4444	1	Data	datum	NNS
cord-006860-a3b8hyyr	4444	2	were	be	VBD
cord-006860-a3b8hyyr	4444	3	compared	compare	VBN
cord-006860-a3b8hyyr	4444	4	by	by	IN
cord-006860-a3b8hyyr	4444	5	the	the	DT
cord-006860-a3b8hyyr	4444	6	paired	paired	JJ
cord-006860-a3b8hyyr	4444	7	student	student	NN
cord-006860-a3b8hyyr	4444	8	's	's	POS
cord-006860-a3b8hyyr	4444	9	t	t	NN
cord-006860-a3b8hyyr	4444	10	-	-	HYPH
cord-006860-a3b8hyyr	4444	11	test	test	NN
cord-006860-a3b8hyyr	4444	12	,	,	,
cord-006860-a3b8hyyr	4444	13	p<0,05	p<0,05	NNP
cord-006860-a3b8hyyr	4444	14	was	be	VBD
cord-006860-a3b8hyyr	4444	15	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	4444	16	as	as	IN
cord-006860-a3b8hyyr	4444	17	significant	significant	JJ
cord-006860-a3b8hyyr	4444	18	.	.	.
cord-006860-a3b8hyyr	4445	1	Results	result	NNS
cord-006860-a3b8hyyr	4445	2	:	:	:
cord-006860-a3b8hyyr	4446	1	MFI	MFI	NNP
cord-006860-a3b8hyyr	4446	2	for	for	IN
cord-006860-a3b8hyyr	4446	3	all	all	DT
cord-006860-a3b8hyyr	4446	4	markers	marker	NNS
cord-006860-a3b8hyyr	4446	5	was	be	VBD
cord-006860-a3b8hyyr	4446	6	comparable	comparable	JJ
cord-006860-a3b8hyyr	4446	7	in	in	IN
cord-006860-a3b8hyyr	4446	8	all	all	DT
cord-006860-a3b8hyyr	4446	9	cell	cell	NN
cord-006860-a3b8hyyr	4446	10	populations	population	NNS
cord-006860-a3b8hyyr	4446	11	in	in	IN
cord-006860-a3b8hyyr	4446	12	samples	sample	NNS
cord-006860-a3b8hyyr	4446	13	obtained	obtain	VBN
cord-006860-a3b8hyyr	4446	14	before	before	IN
cord-006860-a3b8hyyr	4446	15	ischemia	ischemia	NN
cord-006860-a3b8hyyr	4446	16	from	from	IN
cord-006860-a3b8hyyr	4446	17	both	both	DT
cord-006860-a3b8hyyr	4446	18	arms	arm	NNS
cord-006860-a3b8hyyr	4446	19	.	.	.
cord-006860-a3b8hyyr	4447	1	In	in	IN
cord-006860-a3b8hyyr	4447	2	contrast	contrast	NN
cord-006860-a3b8hyyr	4447	3	,	,	,
cord-006860-a3b8hyyr	4447	4	expression	expression	NN
cord-006860-a3b8hyyr	4447	5	of	of	IN
cord-006860-a3b8hyyr	4447	6	CD18	CD18	NNP
cord-006860-a3b8hyyr	4447	7	was	be	VBD
cord-006860-a3b8hyyr	4447	8	significantly	significantly	RB
cord-006860-a3b8hyyr	4447	9	enhanced	enhance	VBN
cord-006860-a3b8hyyr	4447	10	in	in	IN
cord-006860-a3b8hyyr	4447	11	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4447	12	(	(	-LRB-
cord-006860-a3b8hyyr	4447	13	321_+50	321_+50	NNP
cord-006860-a3b8hyyr	4447	14	vs.	vs.	IN
cord-006860-a3b8hyyr	4447	15	189_+38	189_+38	NNP
cord-006860-a3b8hyyr	4447	16	)	)	-RRB-
cord-006860-a3b8hyyr	4447	17	,	,	,
cord-006860-a3b8hyyr	4447	18	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	4447	19	(	(	-LRB-
cord-006860-a3b8hyyr	4447	20	653-+54	653-+54	JJ
cord-006860-a3b8hyyr	4447	21	vs.	vs.	FW
cord-006860-a3b8hyyr	4447	22	426	426	CD
cord-006860-a3b8hyyr	4447	23	+	+	SYM
cord-006860-a3b8hyyr	4447	24	122	122	CD
cord-006860-a3b8hyyr	4447	25	)	)	-RRB-
cord-006860-a3b8hyyr	4447	26	and	and	CC
cord-006860-a3b8hyyr	4447	27	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	4447	28	(	(	-LRB-
cord-006860-a3b8hyyr	4447	29	299_+45	299_+45	CD
cord-006860-a3b8hyyr	4447	30	vs.	vs.	IN
cord-006860-a3b8hyyr	4447	31	228-+36	228-+36	CD
cord-006860-a3b8hyyr	4447	32	)	)	-RRB-
cord-006860-a3b8hyyr	4447	33	from	from	IN
cord-006860-a3b8hyyr	4447	34	samples	sample	NNS
cord-006860-a3b8hyyr	4447	35	derived	derive	VBN
cord-006860-a3b8hyyr	4447	36	from	from	IN
cord-006860-a3b8hyyr	4447	37	the	the	DT
cord-006860-a3b8hyyr	4447	38	ischamic	ischamic	JJ
cord-006860-a3b8hyyr	4447	39	arm	arm	NN
cord-006860-a3b8hyyr	4447	40	,	,	,
cord-006860-a3b8hyyr	4447	41	as	as	IN
cord-006860-a3b8hyyr	4447	42	compared	compare	VBN
cord-006860-a3b8hyyr	4447	43	with	with	IN
cord-006860-a3b8hyyr	4447	44	the	the	DT
cord-006860-a3b8hyyr	4447	45	nonischemic	nonischemic	NNP
cord-006860-a3b8hyyr	4447	46	arm	arm	NN
cord-006860-a3b8hyyr	4447	47	,	,	,
cord-006860-a3b8hyyr	4447	48	as	as	IN
cord-006860-a3b8hyyr	4447	49	measured	measure	VBN
cord-006860-a3b8hyyr	4447	50	at	at	IN
cord-006860-a3b8hyyr	4447	51	end	end	NN
cord-006860-a3b8hyyr	4447	52	of	of	IN
cord-006860-a3b8hyyr	4447	53	ischemia	ischemia	NN
cord-006860-a3b8hyyr	4447	54	.	.	.
cord-006860-a3b8hyyr	4448	1	At	at	IN
cord-006860-a3b8hyyr	4448	2	the	the	DT
cord-006860-a3b8hyyr	4448	3	same	same	JJ
cord-006860-a3b8hyyr	4448	4	time	time	NN
cord-006860-a3b8hyyr	4448	5	,	,	,
cord-006860-a3b8hyyr	4448	6	an	an	DT
cord-006860-a3b8hyyr	4448	7	increase	increase	NN
cord-006860-a3b8hyyr	4448	8	of	of	IN
cord-006860-a3b8hyyr	4448	9	CDf	CDf	NNS
cord-006860-a3b8hyyr	4448	10	lb	lb	CD
cord-006860-a3b8hyyr	4448	11	on	on	IN
cord-006860-a3b8hyyr	4448	12	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4448	13	(	(	-LRB-
cord-006860-a3b8hyyr	4448	14	500~_342	500~_342	CD
cord-006860-a3b8hyyr	4448	15	vs.	vs.	IN
cord-006860-a3b8hyyr	4448	16	213	213	CD
cord-006860-a3b8hyyr	4448	17	+	+	SYM
cord-006860-a3b8hyyr	4448	18	150	150	CD
cord-006860-a3b8hyyr	4448	19	)	)	-RRB-
cord-006860-a3b8hyyr	4448	20	and	and	CC
cord-006860-a3b8hyyr	4448	21	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	4448	22	(	(	-LRB-
cord-006860-a3b8hyyr	4448	23	533	533	CD
cord-006860-a3b8hyyr	4448	24	+	+	SYM
cord-006860-a3b8hyyr	4448	25	359	359	CD
cord-006860-a3b8hyyr	4448	26	vs.237-+206	vs.237-+206	NNPS
cord-006860-a3b8hyyr	4448	27	)	)	-RRB-
cord-006860-a3b8hyyr	4448	28	but	but	CC
cord-006860-a3b8hyyr	4448	29	not	not	RB
cord-006860-a3b8hyyr	4448	30	on	on	IN
cord-006860-a3b8hyyr	4448	31	lymphocytes	lymphocyte	NNS
cord-006860-a3b8hyyr	4448	32	was	be	VBD
cord-006860-a3b8hyyr	4448	33	found	find	VBN
cord-006860-a3b8hyyr	4448	34	,	,	,
cord-006860-a3b8hyyr	4448	35	No	no	DT
cord-006860-a3b8hyyr	4448	36	modifications	modification	NNS
cord-006860-a3b8hyyr	4448	37	of	of	IN
cord-006860-a3b8hyyr	4448	38	CDlta	CDlta	NNP
cord-006860-a3b8hyyr	4448	39	and	and	CC
cord-006860-a3b8hyyr	4448	40	CDttc	CDttc	NNP
cord-006860-a3b8hyyr	4448	41	expression	expression	NN
cord-006860-a3b8hyyr	4448	42	could	could	MD
cord-006860-a3b8hyyr	4448	43	be	be	VB
cord-006860-a3b8hyyr	4448	44	observed	observe	VBN
cord-006860-a3b8hyyr	4448	45	.	.	.
cord-006860-a3b8hyyr	4449	1	There	there	EX
cord-006860-a3b8hyyr	4449	2	was	be	VBD
cord-006860-a3b8hyyr	4449	3	no	no	DT
cord-006860-a3b8hyyr	4449	4	correlation	correlation	NN
cord-006860-a3b8hyyr	4449	5	between	between	IN
cord-006860-a3b8hyyr	4449	6	duration	duration	NN
cord-006860-a3b8hyyr	4449	7	of	of	IN
cord-006860-a3b8hyyr	4449	8	ischemia	ischemia	NN
cord-006860-a3b8hyyr	4449	9	and	and	CC
cord-006860-a3b8hyyr	4449	10	quantitative	quantitative	JJ
cord-006860-a3b8hyyr	4449	11	expression	expression	NN
cord-006860-a3b8hyyr	4449	12	of	of	IN
cord-006860-a3b8hyyr	4449	13	these	these	DT
cord-006860-a3b8hyyr	4449	14	markers	marker	NNS
cord-006860-a3b8hyyr	4449	15	,	,	,
cord-006860-a3b8hyyr	4449	16	Conclusions	conclusion	NNS
cord-006860-a3b8hyyr	4449	17	:	:	:
cord-006860-a3b8hyyr	4450	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	4450	2	data	datum	NNS
cord-006860-a3b8hyyr	4450	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	4450	4	that	that	IN
cord-006860-a3b8hyyr	4450	5	relatively	relatively	RB
cord-006860-a3b8hyyr	4450	6	short	short	JJ
cord-006860-a3b8hyyr	4450	7	ischemia	ischemia	NN
cord-006860-a3b8hyyr	4450	8	periods	period	NNS
cord-006860-a3b8hyyr	4450	9	induce	induce	VBP
cord-006860-a3b8hyyr	4450	10	an	an	DT
cord-006860-a3b8hyyr	4450	11	increased	increase	VBN
cord-006860-a3b8hyyr	4450	12	expression	expression	NN
cord-006860-a3b8hyyr	4450	13	of	of	IN
cord-006860-a3b8hyyr	4450	14	~2	~2	NNP
cord-006860-a3b8hyyr	4450	15	"	"	``
cord-006860-a3b8hyyr	4450	16	integrins	integrin	NNS
cord-006860-a3b8hyyr	4450	17	adhesion	adhesion	NN
cord-006860-a3b8hyyr	4450	18	molecules	molecule	NNS
cord-006860-a3b8hyyr	4450	19	on	on	IN
cord-006860-a3b8hyyr	4450	20	leucocytes	leucocyte	NNS
cord-006860-a3b8hyyr	4450	21	.	.	.
cord-006860-a3b8hyyr	4451	1	These	these	DT
cord-006860-a3b8hyyr	4451	2	results	result	NNS
cord-006860-a3b8hyyr	4451	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	4451	4	,	,	,
cord-006860-a3b8hyyr	4451	5	at	at	IN
cord-006860-a3b8hyyr	4451	6	close	close	JJ
cord-006860-a3b8hyyr	4451	7	similarity	similarity	NN
cord-006860-a3b8hyyr	4451	8	with	with	IN
cord-006860-a3b8hyyr	4451	9	findings	finding	NNS
cord-006860-a3b8hyyr	4451	10	from	from	IN
cord-006860-a3b8hyyr	4451	11	expodmental	expodmental	JJ
cord-006860-a3b8hyyr	4451	12	models	model	NNS
cord-006860-a3b8hyyr	4451	13	,	,	,
cord-006860-a3b8hyyr	4451	14	that	that	DT
cord-006860-a3b8hyyr	4451	15	overexpression	overexpression	NN
cord-006860-a3b8hyyr	4451	16	of	of	IN
cord-006860-a3b8hyyr	4451	17	adhesion	adhesion	NN
cord-006860-a3b8hyyr	4451	18	molecules	molecule	NNS
cord-006860-a3b8hyyr	4451	19	might	may	MD
cord-006860-a3b8hyyr	4451	20	play	play	VB
cord-006860-a3b8hyyr	4451	21	an	an	DT
cord-006860-a3b8hyyr	4451	22	important	important	JJ
cord-006860-a3b8hyyr	4451	23	role	role	NN
cord-006860-a3b8hyyr	4451	24	in	in	IN
cord-006860-a3b8hyyr	4451	25	the	the	DT
cord-006860-a3b8hyyr	4451	26	induction	induction	NN
cord-006860-a3b8hyyr	4451	27	of	of	IN
cord-006860-a3b8hyyr	4451	28	ischemia	ischemia	NN
cord-006860-a3b8hyyr	4451	29	/	/	SYM
cord-006860-a3b8hyyr	4451	30	reperfusion	reperfusion	NN
cord-006860-a3b8hyyr	4451	31	injury	injury	NN
cord-006860-a3b8hyyr	4451	32	,	,	,
cord-006860-a3b8hyyr	4451	33	in	in	IN
cord-006860-a3b8hyyr	4451	34	humans	human	NNS
cord-006860-a3b8hyyr	4451	35	.	.	.
cord-006860-a3b8hyyr	4452	1	In	in	IN
cord-006860-a3b8hyyr	4452	2	patients	patient	NNS
cord-006860-a3b8hyyr	4452	3	suffering	suffer	VBG
cord-006860-a3b8hyyr	4452	4	from	from	IN
cord-006860-a3b8hyyr	4452	5	chronic	chronic	JJ
cord-006860-a3b8hyyr	4452	6	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	4452	7	bowel	bowel	NN
cord-006860-a3b8hyyr	4452	8	diseases	disease	NNS
cord-006860-a3b8hyyr	4452	9	,	,	,
cord-006860-a3b8hyyr	4452	10	such	such	JJ
cord-006860-a3b8hyyr	4452	11	as	as	IN
cord-006860-a3b8hyyr	4452	12	Morbus	Morbus	NNP
cord-006860-a3b8hyyr	4452	13	Crohn	Crohn	NNP
cord-006860-a3b8hyyr	4452	14	and	and	CC
cord-006860-a3b8hyyr	4452	15	Colitis	Colitis	NNP
cord-006860-a3b8hyyr	4452	16	ulcerosa	ulcerosa	NNP
cord-006860-a3b8hyyr	4452	17	,	,	,
cord-006860-a3b8hyyr	4452	18	we	-PRON-	PRP
cord-006860-a3b8hyyr	4452	19	observe	observe	VBP
cord-006860-a3b8hyyr	4452	20	massive	massive	JJ
cord-006860-a3b8hyyr	4452	21	,	,	,
cord-006860-a3b8hyyr	4452	22	sometimes	sometimes	RB
cord-006860-a3b8hyyr	4452	23	barely	barely	RB
cord-006860-a3b8hyyr	4452	24	staunchable	staunchable	JJ
cord-006860-a3b8hyyr	4452	25	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	4452	26	.	.	.
cord-006860-a3b8hyyr	4453	1	Hereby	hereby	RB
cord-006860-a3b8hyyr	4453	2	,	,	,
cord-006860-a3b8hyyr	4453	3	the	the	DT
cord-006860-a3b8hyyr	4453	4	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4453	5	of	of	IN
cord-006860-a3b8hyyr	4453	6	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4453	7	factors	factor	NNS
cord-006860-a3b8hyyr	4453	8	,	,	,
cord-006860-a3b8hyyr	4453	9	especially	especially	RB
cord-006860-a3b8hyyr	4453	10	of	of	IN
cord-006860-a3b8hyyr	4453	11	factor	factor	NN
cord-006860-a3b8hyyr	4453	12	XIII	XIII	NNP
cord-006860-a3b8hyyr	4453	13	in	in	IN
cord-006860-a3b8hyyr	4453	14	plasma	plasma	NN
cord-006860-a3b8hyyr	4453	15	is	be	VBZ
cord-006860-a3b8hyyr	4453	16	established	establish	VBN
cord-006860-a3b8hyyr	4453	17	.	.	.
cord-006860-a3b8hyyr	4454	1	ttowever	ttowever	NNP
cord-006860-a3b8hyyr	4454	2	the	the	DT
cord-006860-a3b8hyyr	4454	3	influence	influence	NN
cord-006860-a3b8hyyr	4454	4	of	of	IN
cord-006860-a3b8hyyr	4454	5	factor	factor	NN
cord-006860-a3b8hyyr	4454	6	XIII	XIII	NNP
cord-006860-a3b8hyyr	4454	7	on	on	IN
cord-006860-a3b8hyyr	4454	8	the	the	DT
cord-006860-a3b8hyyr	4454	9	pathomechanism	pathomechanism	NN
cord-006860-a3b8hyyr	4454	10	of	of	IN
cord-006860-a3b8hyyr	4454	11	the	the	DT
cord-006860-a3b8hyyr	4454	12	underlying	underlying	JJ
cord-006860-a3b8hyyr	4454	13	disease	disease	NN
cord-006860-a3b8hyyr	4454	14	is	be	VBZ
cord-006860-a3b8hyyr	4454	15	still	still	RB
cord-006860-a3b8hyyr	4454	16	under	under	IN
cord-006860-a3b8hyyr	4454	17	discussion	discussion	NN
cord-006860-a3b8hyyr	4454	18	.	.	.
cord-006860-a3b8hyyr	4455	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	4455	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	4455	3	studied	study	VBD
cord-006860-a3b8hyyr	4455	4	the	the	DT
cord-006860-a3b8hyyr	4455	5	F	F	NNP
cord-006860-a3b8hyyr	4455	6	XIII	XIII	NNP
cord-006860-a3b8hyyr	4455	7	content	content	NN
cord-006860-a3b8hyyr	4455	8	in	in	IN
cord-006860-a3b8hyyr	4455	9	the	the	DT
cord-006860-a3b8hyyr	4455	10	intestinal	intestinal	JJ
cord-006860-a3b8hyyr	4455	11	mucosa	mucosa	NN
cord-006860-a3b8hyyr	4455	12	.	.	.
cord-006860-a3b8hyyr	4456	1	An	an	DT
cord-006860-a3b8hyyr	4456	2	immunohistochemicat	immunohistochemicat	NN
cord-006860-a3b8hyyr	4456	3	method	method	NN
cord-006860-a3b8hyyr	4456	4	was	be	VBD
cord-006860-a3b8hyyr	4456	5	developed	develop	VBN
cord-006860-a3b8hyyr	4456	6	using	use	VBG
cord-006860-a3b8hyyr	4456	7	commercially	commercially	RB
cord-006860-a3b8hyyr	4456	8	available	available	JJ
cord-006860-a3b8hyyr	4456	9	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4456	10	against	against	IN
cord-006860-a3b8hyyr	4456	11	F	F	NNP
cord-006860-a3b8hyyr	4456	12	XIII	XIII	NNP
cord-006860-a3b8hyyr	4456	13	subunit	subunit	NN
cord-006860-a3b8hyyr	4456	14	-	-	:
cord-006860-a3b8hyyr	4456	15	A	A	NNP
cord-006860-a3b8hyyr	4456	16	,	,	,
cord-006860-a3b8hyyr	4456	17	the	the	DT
cord-006860-a3b8hyyr	4456	18	detection	detection	NN
cord-006860-a3b8hyyr	4456	19	of	of	IN
cord-006860-a3b8hyyr	4456	20	mucosal	mucosal	JJ
cord-006860-a3b8hyyr	4456	21	factor	factor	NN
cord-006860-a3b8hyyr	4456	22	XIII	XIII	NNP
cord-006860-a3b8hyyr	4456	23	depends	depend	VBZ
cord-006860-a3b8hyyr	4456	24	on	on	IN
cord-006860-a3b8hyyr	4456	25	the	the	DT
cord-006860-a3b8hyyr	4456	26	amount	amount	NN
cord-006860-a3b8hyyr	4456	27	of	of	IN
cord-006860-a3b8hyyr	4456	28	chromogen	chromogen	NN
cord-006860-a3b8hyyr	4456	29	bound	bind	VBN
cord-006860-a3b8hyyr	4456	30	to	to	IN
cord-006860-a3b8hyyr	4456	31	the	the	DT
cord-006860-a3b8hyyr	4456	32	antibody	antibody	NN
cord-006860-a3b8hyyr	4456	33	-	-	HYPH
cord-006860-a3b8hyyr	4456	34	horseradish	horseradish	NN
cord-006860-a3b8hyyr	4456	35	-	-	HYPH
cord-006860-a3b8hyyr	4456	36	peroxidase	peroxidase	NN
cord-006860-a3b8hyyr	4456	37	complex	complex	NN
cord-006860-a3b8hyyr	4456	38	.	.	.
cord-006860-a3b8hyyr	4457	1	With	with	IN
cord-006860-a3b8hyyr	4457	2	this	this	DT
cord-006860-a3b8hyyr	4457	3	method	method	NN
cord-006860-a3b8hyyr	4457	4	,	,	,
cord-006860-a3b8hyyr	4457	5	it	-PRON-	PRP
cord-006860-a3b8hyyr	4457	6	is	be	VBZ
cord-006860-a3b8hyyr	4457	7	possible	possible	JJ
cord-006860-a3b8hyyr	4457	8	to	to	TO
cord-006860-a3b8hyyr	4457	9	locate	locate	VB
cord-006860-a3b8hyyr	4457	10	but	but	CC
cord-006860-a3b8hyyr	4457	11	not	not	RB
cord-006860-a3b8hyyr	4457	12	to	to	TO
cord-006860-a3b8hyyr	4457	13	quantify	quantify	VB
cord-006860-a3b8hyyr	4457	14	F	F	NNP
cord-006860-a3b8hyyr	4457	15	XIlI	XIlI	NNP
cord-006860-a3b8hyyr	4457	16	in	in	IN
cord-006860-a3b8hyyr	4457	17	the	the	DT
cord-006860-a3b8hyyr	4457	18	intestinal	intestinal	JJ
cord-006860-a3b8hyyr	4457	19	tissue	tissue	NN
cord-006860-a3b8hyyr	4457	20	.	.	.
cord-006860-a3b8hyyr	4458	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	4458	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	4458	3	developed	develop	VBD
cord-006860-a3b8hyyr	4458	4	an	an	DT
cord-006860-a3b8hyyr	4458	5	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	4458	6	-	-	HYPH
cord-006860-a3b8hyyr	4458	7	metbod	metbod	NN
cord-006860-a3b8hyyr	4458	8	in	in	IN
cord-006860-a3b8hyyr	4458	9	homogenized	homogenized	JJ
cord-006860-a3b8hyyr	4458	10	intestinal	intestinal	JJ
cord-006860-a3b8hyyr	4458	11	tissue	tissue	NN
cord-006860-a3b8hyyr	4458	12	,	,	,
cord-006860-a3b8hyyr	4458	13	using	use	VBG
cord-006860-a3b8hyyr	4458	14	commercially	commercially	RB
cord-006860-a3b8hyyr	4458	15	available	available	JJ
cord-006860-a3b8hyyr	4458	16	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4458	17	.	.	.
cord-006860-a3b8hyyr	4459	1	Its	-PRON-	PRP$
cord-006860-a3b8hyyr	4459	2	precision	precision	NN
cord-006860-a3b8hyyr	4459	3	was	be	VBD
cord-006860-a3b8hyyr	4459	4	validated	validate	VBN
cord-006860-a3b8hyyr	4459	5	using	use	VBG
cord-006860-a3b8hyyr	4459	6	a	a	DT
cord-006860-a3b8hyyr	4459	7	standard	standard	JJ
cord-006860-a3b8hyyr	4459	8	curve	curve	NN
cord-006860-a3b8hyyr	4459	9	with	with	IN
cord-006860-a3b8hyyr	4459	10	commercially	commercially	RB
cord-006860-a3b8hyyr	4459	11	available	available	JJ
cord-006860-a3b8hyyr	4459	12	factor	factor	NN
cord-006860-a3b8hyyr	4459	13	XIII	XIII	NNP
cord-006860-a3b8hyyr	4459	14	preparations	preparation	NNS
cord-006860-a3b8hyyr	4459	15	(	(	-LRB-
cord-006860-a3b8hyyr	4459	16	Fibrogemmin	Fibrogemmin	NNP
cord-006860-a3b8hyyr	4459	17	®	®	NNP
cord-006860-a3b8hyyr	4459	18	)	)	-RRB-
cord-006860-a3b8hyyr	4459	19	.	.	.
cord-006860-a3b8hyyr	4460	1	The	the	DT
cord-006860-a3b8hyyr	4460	2	detection	detection	NN
cord-006860-a3b8hyyr	4460	3	limit	limit	NN
cord-006860-a3b8hyyr	4460	4	of	of	IN
cord-006860-a3b8hyyr	4460	5	this	this	DT
cord-006860-a3b8hyyr	4460	6	method	method	NN
cord-006860-a3b8hyyr	4460	7	is	be	VBZ
cord-006860-a3b8hyyr	4460	8	>	>	NFP
cord-006860-a3b8hyyr	4460	9	0.05	0.05	CD
cord-006860-a3b8hyyr	4460	10	I.U.	I.U.	NNP
cord-006860-a3b8hyyr	4460	11	F	F	NNP
cord-006860-a3b8hyyr	4460	12	XIII	XIII	NNP
cord-006860-a3b8hyyr	4460	13	/	/	,
cord-006860-a3b8hyyr	4460	14	ml	ml	NN
cord-006860-a3b8hyyr	4460	15	of	of	IN
cord-006860-a3b8hyyr	4460	16	tissue	tissue	NN
cord-006860-a3b8hyyr	4460	17	solution	solution	NN
cord-006860-a3b8hyyr	4460	18	.	.	.
cord-006860-a3b8hyyr	4461	1	Freezed	Freezed	NNP
cord-006860-a3b8hyyr	4461	2	dried	dry	VBD
cord-006860-a3b8hyyr	4461	3	intestinal	intestinal	JJ
cord-006860-a3b8hyyr	4461	4	tissue	tissue	NN
cord-006860-a3b8hyyr	4461	5	(	(	-LRB-
cord-006860-a3b8hyyr	4461	6	lmg	lmg	NNP
cord-006860-a3b8hyyr	4461	7	)	)	-RRB-
cord-006860-a3b8hyyr	4461	8	was	be	VBD
cord-006860-a3b8hyyr	4461	9	homogenized	homogenize	VBN
cord-006860-a3b8hyyr	4461	10	in	in	IN
cord-006860-a3b8hyyr	4461	11	1	1	CD
cord-006860-a3b8hyyr	4461	12	ml	ml	NN
cord-006860-a3b8hyyr	4461	13	buffer	buffer	NN
cord-006860-a3b8hyyr	4461	14	using	use	VBG
cord-006860-a3b8hyyr	4461	15	a	a	DT
cord-006860-a3b8hyyr	4461	16	potter	potter	NN
cord-006860-a3b8hyyr	4461	17	.	.	.
cord-006860-a3b8hyyr	4462	1	Specimens	specimen	NNS
cord-006860-a3b8hyyr	4462	2	of	of	IN
cord-006860-a3b8hyyr	4462	3	the	the	DT
cord-006860-a3b8hyyr	4462	4	large	large	JJ
cord-006860-a3b8hyyr	4462	5	bowel	bowel	NN
cord-006860-a3b8hyyr	4462	6	revealed	reveal	VBD
cord-006860-a3b8hyyr	4462	7	F	F	NNP
cord-006860-a3b8hyyr	4462	8	XIII	XIII	NNP
cord-006860-a3b8hyyr	4462	9	values	value	NNS
cord-006860-a3b8hyyr	4462	10	of	of	IN
cord-006860-a3b8hyyr	4462	11	0,21	0,21	CD
cord-006860-a3b8hyyr	4462	12	+	+	CC
cord-006860-a3b8hyyr	4462	13	0,0038	0,0038	JJ
cord-006860-a3b8hyyr	4462	14	I.U.	I.U.	NNP
cord-006860-a3b8hyyr	4463	1	(	(	-LRB-
cord-006860-a3b8hyyr	4463	2	x	x	NN
cord-006860-a3b8hyyr	4463	3	_	_	NNP
cord-006860-a3b8hyyr	4463	4	_	_	NN
cord-006860-a3b8hyyr	4463	5	+	+	CC
cord-006860-a3b8hyyr	4463	6	SD	SD	NNP
cord-006860-a3b8hyyr	4463	7	)	)	-RRB-
cord-006860-a3b8hyyr	4463	8	,	,	,
cord-006860-a3b8hyyr	4463	9	tissue	tissue	NN
cord-006860-a3b8hyyr	4463	10	solution	solution	NN
cord-006860-a3b8hyyr	4463	11	.	.	.
cord-006860-a3b8hyyr	4464	1	With	with	IN
cord-006860-a3b8hyyr	4464	2	this	this	DT
cord-006860-a3b8hyyr	4464	3	method	method	NN
cord-006860-a3b8hyyr	4464	4	it	-PRON-	PRP
cord-006860-a3b8hyyr	4464	5	is	be	VBZ
cord-006860-a3b8hyyr	4464	6	possible	possible	JJ
cord-006860-a3b8hyyr	4464	7	to	to	TO
cord-006860-a3b8hyyr	4464	8	quantify	quantify	VB
cord-006860-a3b8hyyr	4464	9	tissue	tissue	NN
cord-006860-a3b8hyyr	4464	10	-	-	HYPH
cord-006860-a3b8hyyr	4464	11	bound	bind	VBN
cord-006860-a3b8hyyr	4464	12	faxtor	faxtor	NN
cord-006860-a3b8hyyr	4464	13	XIII	XIII	NNP
cord-006860-a3b8hyyr	4464	14	.	.	.
cord-006860-a3b8hyyr	4465	1	Studies	study	NNS
cord-006860-a3b8hyyr	4465	2	are	be	VBP
cord-006860-a3b8hyyr	4465	3	in	in	IN
cord-006860-a3b8hyyr	4465	4	progress	progress	NN
cord-006860-a3b8hyyr	4465	5	to	to	TO
cord-006860-a3b8hyyr	4465	6	elucidate	elucidate	VB
cord-006860-a3b8hyyr	4465	7	the	the	DT
cord-006860-a3b8hyyr	4465	8	content	content	NN
cord-006860-a3b8hyyr	4465	9	of	of	IN
cord-006860-a3b8hyyr	4465	10	F	F	NNP
cord-006860-a3b8hyyr	4465	11	XIII	XIII	NNP
cord-006860-a3b8hyyr	4465	12	in	in	IN
cord-006860-a3b8hyyr	4465	13	the	the	DT
cord-006860-a3b8hyyr	4465	14	intestine	intestine	NN
cord-006860-a3b8hyyr	4465	15	of	of	IN
cord-006860-a3b8hyyr	4465	16	patient	patient	NN
cord-006860-a3b8hyyr	4465	17	's	's	POS
cord-006860-a3b8hyyr	4465	18	suffering	suffering	NN
cord-006860-a3b8hyyr	4465	19	from	from	IN
cord-006860-a3b8hyyr	4465	20	infammatory	infammatory	JJ
cord-006860-a3b8hyyr	4465	21	bowel	bowel	NN
cord-006860-a3b8hyyr	4465	22	diseases	disease	NNS
cord-006860-a3b8hyyr	4465	23	in	in	IN
cord-006860-a3b8hyyr	4465	24	order	order	NN
cord-006860-a3b8hyyr	4465	25	to	to	TO
cord-006860-a3b8hyyr	4465	26	contribute	contribute	VB
cord-006860-a3b8hyyr	4465	27	data	datum	NNS
cord-006860-a3b8hyyr	4465	28	to	to	IN
cord-006860-a3b8hyyr	4465	29	the	the	DT
cord-006860-a3b8hyyr	4465	30	pathomechanisms	pathomechanism	NNS
cord-006860-a3b8hyyr	4465	31	of	of	IN
cord-006860-a3b8hyyr	4465	32	F	F	NNP
cord-006860-a3b8hyyr	4465	33	XIII	XIII	NNP
cord-006860-a3b8hyyr	4465	34	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4465	35	.	.	.
cord-006860-a3b8hyyr	4466	1	In	in	IN
cord-006860-a3b8hyyr	4466	2	a	a	DT
cord-006860-a3b8hyyr	4466	3	previous	previous	JJ
cord-006860-a3b8hyyr	4466	4	double	double	JJ
cord-006860-a3b8hyyr	4466	5	-	-	HYPH
cord-006860-a3b8hyyr	4466	6	blind	blind	JJ
cord-006860-a3b8hyyr	4466	7	,	,	,
cord-006860-a3b8hyyr	4466	8	controlled	control	VBN
cord-006860-a3b8hyyr	4466	9	trial	trial	NN
cord-006860-a3b8hyyr	4466	10	we	-PRON-	PRP
cord-006860-a3b8hyyr	4466	11	were	be	VBD
cord-006860-a3b8hyyr	4466	12	able	able	JJ
cord-006860-a3b8hyyr	4466	13	to	to	TO
cord-006860-a3b8hyyr	4466	14	show	show	VB
cord-006860-a3b8hyyr	4466	15	that	that	IN
cord-006860-a3b8hyyr	4466	16	aprotinin	aprotinin	NNP
cord-006860-a3b8hyyr	4466	17	administration	administration	NN
cord-006860-a3b8hyyr	4466	18	has	have	VBZ
cord-006860-a3b8hyyr	4466	19	significantly	significantly	RB
cord-006860-a3b8hyyr	4466	20	contributed	contribute	VBN
cord-006860-a3b8hyyr	4466	21	to	to	TO
cord-006860-a3b8hyyr	4466	22	reduce	reduce	VB
cord-006860-a3b8hyyr	4466	23	periand	periand	NN
cord-006860-a3b8hyyr	4466	24	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	4466	25	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4466	26	complications	complication	NNS
cord-006860-a3b8hyyr	4466	27	without	without	IN
cord-006860-a3b8hyyr	4466	28	increasing	increase	VBG
cord-006860-a3b8hyyr	4466	29	the	the	DT
cord-006860-a3b8hyyr	4466	30	risk	risk	NN
cord-006860-a3b8hyyr	4466	31	of	of	IN
cord-006860-a3b8hyyr	4466	32	thromboembotic	thromboembotic	JJ
cord-006860-a3b8hyyr	4466	33	complications	complication	NNS
cord-006860-a3b8hyyr	4466	34	.	.	.
cord-006860-a3b8hyyr	4467	1	The	the	DT
cord-006860-a3b8hyyr	4467	2	question	question	NN
cord-006860-a3b8hyyr	4467	3	arises	arise	VBZ
cord-006860-a3b8hyyr	4467	4	whether	whether	IN
cord-006860-a3b8hyyr	4467	5	this	this	DT
cord-006860-a3b8hyyr	4467	6	beneficial	beneficial	JJ
cord-006860-a3b8hyyr	4467	7	effect	effect	NN
cord-006860-a3b8hyyr	4467	8	may	may	MD
cord-006860-a3b8hyyr	4467	9	be	be	VB
cord-006860-a3b8hyyr	4467	10	associated	associate	VBN
cord-006860-a3b8hyyr	4467	11	with	with	IN
cord-006860-a3b8hyyr	4467	12	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4467	13	effects	effect	NNS
cord-006860-a3b8hyyr	4467	14	on	on	IN
cord-006860-a3b8hyyr	4467	15	intraoperative	intraoperative	JJ
cord-006860-a3b8hyyr	4467	16	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	4467	17	.	.	.
cord-006860-a3b8hyyr	4468	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	4468	2	,	,	,
cord-006860-a3b8hyyr	4468	3	20	20	CD
cord-006860-a3b8hyyr	4468	4	patients	patient	NNS
cord-006860-a3b8hyyr	4468	5	were	be	VBD
cord-006860-a3b8hyyr	4468	6	treated	treat	VBN
cord-006860-a3b8hyyr	4468	7	with	with	IN
cord-006860-a3b8hyyr	4468	8	or	or	CC
cord-006860-a3b8hyyr	4468	9	without	without	IN
cord-006860-a3b8hyyr	4468	10	aprotinin	aprotinin	NNP
cord-006860-a3b8hyyr	4468	11	(	(	-LRB-
cord-006860-a3b8hyyr	4468	12	2	2	CD
cord-006860-a3b8hyyr	4468	13	million	million	CD
cord-006860-a3b8hyyr	4468	14	KIU	KIU	NNP
cord-006860-a3b8hyyr	4468	15	loading	loading	NN
cord-006860-a3b8hyyr	4468	16	dose	dose	NN
cord-006860-a3b8hyyr	4468	17	over	over	IN
cord-006860-a3b8hyyr	4468	18	15	15	CD
cord-006860-a3b8hyyr	4468	19	minutes	minute	NNS
cord-006860-a3b8hyyr	4468	20	followed	follow	VBN
cord-006860-a3b8hyyr	4468	21	by	by	IN
cord-006860-a3b8hyyr	4468	22	500,000	500,000	CD
cord-006860-a3b8hyyr	4468	23	KIU	KIU	NNP
cord-006860-a3b8hyyr	4468	24	per	per	IN
cord-006860-a3b8hyyr	4468	25	hour	hour	NN
cord-006860-a3b8hyyr	4468	26	)	)	-RRB-
cord-006860-a3b8hyyr	4468	27	,	,	,
cord-006860-a3b8hyyr	4468	28	and	and	CC
cord-006860-a3b8hyyr	4468	29	citrated	citrate	VBD
cord-006860-a3b8hyyr	4468	30	blood	blood	NN
cord-006860-a3b8hyyr	4468	31	samples	sample	NNS
cord-006860-a3b8hyyr	4468	32	were	be	VBD
cord-006860-a3b8hyyr	4468	33	obtained	obtain	VBN
cord-006860-a3b8hyyr	4468	34	at	at	IN
cord-006860-a3b8hyyr	4468	35	the	the	DT
cord-006860-a3b8hyyr	4468	36	following	following	JJ
cord-006860-a3b8hyyr	4468	37	time	time	NN
cord-006860-a3b8hyyr	4468	38	points	point	NNS
cord-006860-a3b8hyyr	4468	39	:	:	:
cord-006860-a3b8hyyr	4468	40	Before	before	IN
cord-006860-a3b8hyyr	4468	41	operation	operation	NN
cord-006860-a3b8hyyr	4468	42	,	,	,
cord-006860-a3b8hyyr	4468	43	after	after	IN
cord-006860-a3b8hyyr	4468	44	induction	induction	NN
cord-006860-a3b8hyyr	4468	45	of	of	IN
cord-006860-a3b8hyyr	4468	46	the	the	DT
cord-006860-a3b8hyyr	4468	47	anesthesia	anesthesia	NN
cord-006860-a3b8hyyr	4468	48	,	,	,
cord-006860-a3b8hyyr	4468	49	at	at	IN
cord-006860-a3b8hyyr	4468	50	the	the	DT
cord-006860-a3b8hyyr	4468	51	beginning	beginning	NN
cord-006860-a3b8hyyr	4468	52	of	of	IN
cord-006860-a3b8hyyr	4468	53	operation	operation	NN
cord-006860-a3b8hyyr	4468	54	,	,	,
cord-006860-a3b8hyyr	4468	55	intraoperatively	intraoperatively	RB
cord-006860-a3b8hyyr	4468	56	when	when	WRB
cord-006860-a3b8hyyr	4468	57	the	the	DT
cord-006860-a3b8hyyr	4468	58	femur	femur	NN
cord-006860-a3b8hyyr	4468	59	shaft	shaft	NN
cord-006860-a3b8hyyr	4468	60	was	be	VBD
cord-006860-a3b8hyyr	4468	61	implanted	implant	VBN
cord-006860-a3b8hyyr	4468	62	,	,	,
cord-006860-a3b8hyyr	4468	63	and	and	CC
cord-006860-a3b8hyyr	4468	64	24	24	CD
cord-006860-a3b8hyyr	4468	65	hours	hour	NNS
cord-006860-a3b8hyyr	4468	66	postoperatively	postoperatively	RB
cord-006860-a3b8hyyr	4468	67	.	.	.
cord-006860-a3b8hyyr	4469	1	The	the	DT
cord-006860-a3b8hyyr	4469	2	determinations	determination	NNS
cord-006860-a3b8hyyr	4469	3	of	of	IN
cord-006860-a3b8hyyr	4469	4	plasmin	plasmin	NNP
cord-006860-a3b8hyyr	4469	5	/	/	SYM
cord-006860-a3b8hyyr	4469	6	antiplasmin	antiplasmin	NN
cord-006860-a3b8hyyr	4469	7	-	-	HYPH
cord-006860-a3b8hyyr	4469	8	complexes	complex	NNS
cord-006860-a3b8hyyr	4469	9	,	,	,
cord-006860-a3b8hyyr	4469	10	D	D	NNP
cord-006860-a3b8hyyr	4469	11	-	-	HYPH
cord-006860-a3b8hyyr	4469	12	Dimers	Dimers	NNPS
cord-006860-a3b8hyyr	4469	13	,	,	,
cord-006860-a3b8hyyr	4469	14	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4469	15	/	/	SYM
cord-006860-a3b8hyyr	4469	16	Antithrombin	Antithrombin	NNP
cord-006860-a3b8hyyr	4469	17	III	III	NNP
cord-006860-a3b8hyyr	4469	18	-	-	HYPH
cord-006860-a3b8hyyr	4469	19	complexes	complex	NNS
cord-006860-a3b8hyyr	4469	20	,	,	,
cord-006860-a3b8hyyr	4469	21	and	and	CC
cord-006860-a3b8hyyr	4469	22	prothrombinfragments	prothrombinfragment	NNS
cord-006860-a3b8hyyr	4469	23	1	1	CD
cord-006860-a3b8hyyr	4469	24	+2	+2	SYM
cord-006860-a3b8hyyr	4469	25	were	be	VBD
cord-006860-a3b8hyyr	4469	26	performed	perform	VBN
cord-006860-a3b8hyyr	4469	27	by	by	IN
cord-006860-a3b8hyyr	4469	28	means	mean	NNS
cord-006860-a3b8hyyr	4469	29	of	of	IN
cord-006860-a3b8hyyr	4469	30	test	test	NN
cord-006860-a3b8hyyr	4469	31	kits	kit	NNS
cord-006860-a3b8hyyr	4469	32	from	from	IN
cord-006860-a3b8hyyr	4469	33	Behring	Behring	NNP
cord-006860-a3b8hyyr	4469	34	,	,	,
cord-006860-a3b8hyyr	4469	35	Germany	Germany	NNP
cord-006860-a3b8hyyr	4469	36	(	(	-LRB-
cord-006860-a3b8hyyr	4469	37	EnzygnostRpAP	EnzygnostRpAP	NNP
cord-006860-a3b8hyyr	4469	38	micro	micro	NN
cord-006860-a3b8hyyr	4469	39	,	,	,
cord-006860-a3b8hyyr	4469	40	Enzygnost	Enzygnost	NNP
cord-006860-a3b8hyyr	4469	41	R	r	NN
cord-006860-a3b8hyyr	4469	42	D	D	NNP
cord-006860-a3b8hyyr	4469	43	-	-	HYPH
cord-006860-a3b8hyyr	4469	44	Dimer	Dimer	NNP
cord-006860-a3b8hyyr	4469	45	Testkit	Testkit	NNP
cord-006860-a3b8hyyr	4469	46	,	,	,
cord-006860-a3b8hyyr	4470	1	Enzygnost	Enzygnost	NNP
cord-006860-a3b8hyyr	4470	2	R	r	NN
cord-006860-a3b8hyyr	4470	3	TAT	tat	NN
cord-006860-a3b8hyyr	4470	4	micro	micro	NN
cord-006860-a3b8hyyr	4470	5	and	and	CC
cord-006860-a3b8hyyr	4470	6	Enzygnost	Enzygnost	NNP
cord-006860-a3b8hyyr	4470	7	R	r	NN
cord-006860-a3b8hyyr	4470	8	F	f	NN
cord-006860-a3b8hyyr	4470	9	1	1	CD
cord-006860-a3b8hyyr	4470	10	+2	+2	NN
cord-006860-a3b8hyyr	4470	11	respectively	respectively	RB
cord-006860-a3b8hyyr	4470	12	)	)	-RRB-
cord-006860-a3b8hyyr	4470	13	.	.	.
cord-006860-a3b8hyyr	4471	1	-All	-all	WDT
cord-006860-a3b8hyyr	4471	2	markers	marker	NNS
cord-006860-a3b8hyyr	4471	3	of	of	IN
cord-006860-a3b8hyyr	4471	4	activated	activate	VBN
cord-006860-a3b8hyyr	4471	5	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	4471	6	and	and	CC
cord-006860-a3b8hyyr	4471	7	blood	blood	NN
cord-006860-a3b8hyyr	4471	8	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4471	9	were	be	VBD
cord-006860-a3b8hyyr	4471	10	significantly	significantly	RB
cord-006860-a3b8hyyr	4471	11	increased	increase	VBN
cord-006860-a3b8hyyr	4471	12	in	in	IN
cord-006860-a3b8hyyr	4471	13	the	the	DT
cord-006860-a3b8hyyr	4471	14	groups	group	NNS
cord-006860-a3b8hyyr	4471	15	with	with	IN
cord-006860-a3b8hyyr	4471	16	and	and	CC
cord-006860-a3b8hyyr	4471	17	without	without	IN
cord-006860-a3b8hyyr	4471	18	aprotinin	aprotinin	NNP
cord-006860-a3b8hyyr	4471	19	treatment	treatment	NN
cord-006860-a3b8hyyr	4471	20	,	,	,
cord-006860-a3b8hyyr	4471	21	the	the	DT
cord-006860-a3b8hyyr	4471	22	highest	high	JJS
cord-006860-a3b8hyyr	4471	23	activities	activity	NNS
cord-006860-a3b8hyyr	4471	24	to	to	TO
cord-006860-a3b8hyyr	4471	25	be	be	VB
cord-006860-a3b8hyyr	4471	26	seen	see	VBN
cord-006860-a3b8hyyr	4471	27	when	when	WRB
cord-006860-a3b8hyyr	4471	28	the	the	DT
cord-006860-a3b8hyyr	4471	29	femur	femur	NN
cord-006860-a3b8hyyr	4471	30	shaft	shaft	NN
cord-006860-a3b8hyyr	4471	31	was	be	VBD
cord-006860-a3b8hyyr	4471	32	implanted	implant	VBN
cord-006860-a3b8hyyr	4471	33	.	.	.
cord-006860-a3b8hyyr	4472	1	However	however	RB
cord-006860-a3b8hyyr	4472	2	,	,	,
cord-006860-a3b8hyyr	4472	3	the	the	DT
cord-006860-a3b8hyyr	4472	4	values	value	NNS
cord-006860-a3b8hyyr	4472	5	of	of	IN
cord-006860-a3b8hyyr	4472	6	PAP	pap	NN
cord-006860-a3b8hyyr	4472	7	and	and	CC
cord-006860-a3b8hyyr	4472	8	D	d	NN
cord-006860-a3b8hyyr	4472	9	-	-	HYPH
cord-006860-a3b8hyyr	4472	10	Directs	direct	NNS
cord-006860-a3b8hyyr	4472	11	of	of	IN
cord-006860-a3b8hyyr	4472	12	the	the	DT
cord-006860-a3b8hyyr	4472	13	aprotinin	aprotinin	NNP
cord-006860-a3b8hyyr	4472	14	group	group	NNP
cord-006860-a3b8hyyr	4472	15	were	be	VBD
cord-006860-a3b8hyyr	4472	16	below	below	IN
cord-006860-a3b8hyyr	4472	17	the	the	DT
cord-006860-a3b8hyyr	4472	18	values	value	NNS
cord-006860-a3b8hyyr	4472	19	of	of	IN
cord-006860-a3b8hyyr	4472	20	the	the	DT
cord-006860-a3b8hyyr	4472	21	control	control	NN
cord-006860-a3b8hyyr	4472	22	group	group	NN
cord-006860-a3b8hyyr	4472	23	until	until	IN
cord-006860-a3b8hyyr	4472	24	the	the	DT
cord-006860-a3b8hyyr	4472	25	end	end	NN
cord-006860-a3b8hyyr	4472	26	of	of	IN
cord-006860-a3b8hyyr	4472	27	operation	operation	NN
cord-006860-a3b8hyyr	4472	28	.	.	.
cord-006860-a3b8hyyr	4473	1	The	the	DT
cord-006860-a3b8hyyr	4473	2	markers	marker	NNS
cord-006860-a3b8hyyr	4473	3	of	of	IN
cord-006860-a3b8hyyr	4473	4	activated	activate	VBN
cord-006860-a3b8hyyr	4473	5	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4473	6	showed	show	VBD
cord-006860-a3b8hyyr	4473	7	the	the	DT
cord-006860-a3b8hyyr	4473	8	opposite	opposite	JJ
cord-006860-a3b8hyyr	4473	9	effect	effect	NN
cord-006860-a3b8hyyr	4473	10	,	,	,
cord-006860-a3b8hyyr	4473	11	however	however	RB
cord-006860-a3b8hyyr	4473	12	the	the	DT
cord-006860-a3b8hyyr	4473	13	differences	difference	NNS
cord-006860-a3b8hyyr	4473	14	between	between	IN
cord-006860-a3b8hyyr	4473	15	the	the	DT
cord-006860-a3b8hyyr	4473	16	two	two	CD
cord-006860-a3b8hyyr	4473	17	groups	group	NNS
cord-006860-a3b8hyyr	4473	18	were	be	VBD
cord-006860-a3b8hyyr	4473	19	not	not	RB
cord-006860-a3b8hyyr	4473	20	significant	significant	JJ
cord-006860-a3b8hyyr	4473	21	.	.	.
cord-006860-a3b8hyyr	4474	1	As	as	IN
cord-006860-a3b8hyyr	4474	2	expected	expect	VBN
cord-006860-a3b8hyyr	4474	3	,	,	,
cord-006860-a3b8hyyr	4474	4	the	the	DT
cord-006860-a3b8hyyr	4474	5	aPTT	aptt	NN
cord-006860-a3b8hyyr	4474	6	was	be	VBD
cord-006860-a3b8hyyr	4474	7	significantly	significantly	RB
cord-006860-a3b8hyyr	4474	8	prolonged	prolong	VBN
cord-006860-a3b8hyyr	4474	9	in	in	IN
cord-006860-a3b8hyyr	4474	10	the	the	DT
cord-006860-a3b8hyyr	4474	11	aprotiningroup	aprotiningroup	NN
cord-006860-a3b8hyyr	4474	12	.	.	.
cord-006860-a3b8hyyr	4475	1	The	the	DT
cord-006860-a3b8hyyr	4475	2	aprotinin	aprotinin	NN
cord-006860-a3b8hyyr	4475	3	treatment	treatment	NN
cord-006860-a3b8hyyr	4475	4	was	be	VBD
cord-006860-a3b8hyyr	4475	5	also	also	RB
cord-006860-a3b8hyyr	4475	6	associated	associate	VBN
cord-006860-a3b8hyyr	4475	7	with	with	IN
cord-006860-a3b8hyyr	4475	8	a	a	DT
cord-006860-a3b8hyyr	4475	9	significantly	significantly	RB
cord-006860-a3b8hyyr	4475	10	lower	low	JJR
cord-006860-a3b8hyyr	4475	11	blood	blood	NN
cord-006860-a3b8hyyr	4475	12	loss	loss	NN
cord-006860-a3b8hyyr	4475	13	in	in	IN
cord-006860-a3b8hyyr	4475	14	these	these	DT
cord-006860-a3b8hyyr	4475	15	patients	patient	NNS
cord-006860-a3b8hyyr	4475	16	.	.	.
cord-006860-a3b8hyyr	4476	1	-Concluding	-conclude	VBG
cord-006860-a3b8hyyr	4477	1	it	-PRON-	PRP
cord-006860-a3b8hyyr	4477	2	can	can	MD
cord-006860-a3b8hyyr	4477	3	be	be	VB
cord-006860-a3b8hyyr	4477	4	said	say	VBN
cord-006860-a3b8hyyr	4477	5	it	-PRON-	PRP
cord-006860-a3b8hyyr	4477	6	is	be	VBZ
cord-006860-a3b8hyyr	4477	7	not	not	RB
cord-006860-a3b8hyyr	4477	8	clear	clear	JJ
cord-006860-a3b8hyyr	4477	9	whether	whether	IN
cord-006860-a3b8hyyr	4477	10	the	the	DT
cord-006860-a3b8hyyr	4477	11	blood	blood	NN
cord-006860-a3b8hyyr	4477	12	saving	saving	NN
cord-006860-a3b8hyyr	4477	13	effect	effect	NN
cord-006860-a3b8hyyr	4477	14	of	of	IN
cord-006860-a3b8hyyr	4477	15	aprotinin	aprotinin	NNP
cord-006860-a3b8hyyr	4477	16	may	may	MD
cord-006860-a3b8hyyr	4477	17	be	be	VB
cord-006860-a3b8hyyr	4477	18	exclusively	exclusively	RB
cord-006860-a3b8hyyr	4477	19	attributed	attribute	VBN
cord-006860-a3b8hyyr	4477	20	to	to	IN
cord-006860-a3b8hyyr	4477	21	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4477	22	antiplasmin	antiplasmin	NN
cord-006860-a3b8hyyr	4477	23	activity	activity	NN
cord-006860-a3b8hyyr	4477	24	since	since	IN
cord-006860-a3b8hyyr	4477	25	the	the	DT
cord-006860-a3b8hyyr	4477	26	differences	difference	NNS
cord-006860-a3b8hyyr	4477	27	of	of	IN
cord-006860-a3b8hyyr	4477	28	the	the	DT
cord-006860-a3b8hyyr	4477	29	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	4477	30	parameters	parameter	NNS
cord-006860-a3b8hyyr	4477	31	were	be	VBD
cord-006860-a3b8hyyr	4477	32	not	not	RB
cord-006860-a3b8hyyr	4477	33	statistically	statistically	RB
cord-006860-a3b8hyyr	4477	34	significant	significant	JJ
cord-006860-a3b8hyyr	4477	35	.	.	.
cord-006860-a3b8hyyr	4478	1	Further	further	JJ
cord-006860-a3b8hyyr	4478	2	blood	blood	NN
cord-006860-a3b8hyyr	4478	3	samples	sample	NNS
cord-006860-a3b8hyyr	4478	4	should	should	MD
cord-006860-a3b8hyyr	4478	5	be	be	VB
cord-006860-a3b8hyyr	4478	6	analysed	analyse	VBN
cord-006860-a3b8hyyr	4478	7	between	between	IN
cord-006860-a3b8hyyr	4478	8	the	the	DT
cord-006860-a3b8hyyr	4478	9	implantation	implantation	NN
cord-006860-a3b8hyyr	4478	10	of	of	IN
cord-006860-a3b8hyyr	4478	11	the	the	DT
cord-006860-a3b8hyyr	4478	12	femur	femur	NN
cord-006860-a3b8hyyr	4478	13	shaft	shaft	NN
cord-006860-a3b8hyyr	4478	14	and	and	CC
cord-006860-a3b8hyyr	4478	15	the	the	DT
cord-006860-a3b8hyyr	4478	16	end	end	NN
cord-006860-a3b8hyyr	4478	17	of	of	IN
cord-006860-a3b8hyyr	4478	18	operation	operation	NN
cord-006860-a3b8hyyr	4478	19	.	.	.
cord-006860-a3b8hyyr	4479	1	In	in	IN
cord-006860-a3b8hyyr	4479	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4479	3	laboratory	laboratory	NN
cord-006860-a3b8hyyr	4479	4	large	large	JJ
cord-006860-a3b8hyyr	4479	5	amounts	amount	NNS
cord-006860-a3b8hyyr	4479	6	of	of	IN
cord-006860-a3b8hyyr	4479	7	human	human	JJ
cord-006860-a3b8hyyr	4479	8	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4479	9	are	be	VBP
cord-006860-a3b8hyyr	4479	10	required	require	VBN
cord-006860-a3b8hyyr	4479	11	(	(	-LRB-
cord-006860-a3b8hyyr	4479	12	30	30	CD
cord-006860-a3b8hyyr	4479	13	-	-	SYM
cord-006860-a3b8hyyr	4479	14	50	50	CD
cord-006860-a3b8hyyr	4479	15	mg	mg	NNP
cord-006860-a3b8hyyr	4479	16	/	/	SYM
cord-006860-a3b8hyyr	4479	17	week	week	NN
cord-006860-a3b8hyyr	4479	18	)	)	-RRB-
cord-006860-a3b8hyyr	4479	19	.	.	.
cord-006860-a3b8hyyr	4480	1	As	as	IN
cord-006860-a3b8hyyr	4480	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	4480	3	try	try	VBP
cord-006860-a3b8hyyr	4480	4	to	to	TO
cord-006860-a3b8hyyr	4480	5	produce	produce	VB
cord-006860-a3b8hyyr	4480	6	meizothrombin	meizothrombin	NNP
cord-006860-a3b8hyyr	4480	7	and	and	CC
cord-006860-a3b8hyyr	4480	8	meizothrombin	meizothrombin	NNP
cord-006860-a3b8hyyr	4480	9	-	-	HYPH
cord-006860-a3b8hyyr	4480	10	des	des	NNP
cord-006860-a3b8hyyr	4480	11	-	-	HYPH
cord-006860-a3b8hyyr	4480	12	fragment-1	fragment-1	NNP
cord-006860-a3b8hyyr	4480	13	from	from	IN
cord-006860-a3b8hyyr	4480	14	human	human	JJ
cord-006860-a3b8hyyr	4480	15	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4480	16	and	and	CC
cord-006860-a3b8hyyr	4480	17	to	to	TO
cord-006860-a3b8hyyr	4480	18	apply	apply	VB
cord-006860-a3b8hyyr	4480	19	it	-PRON-	PRP
cord-006860-a3b8hyyr	4480	20	as	as	IN
cord-006860-a3b8hyyr	4480	21	an	an	DT
cord-006860-a3b8hyyr	4480	22	antidote	antidote	NN
cord-006860-a3b8hyyr	4480	23	for	for	IN
cord-006860-a3b8hyyr	4480	24	hirudin	hirudin	NN
cord-006860-a3b8hyyr	4480	25	,	,	,
cord-006860-a3b8hyyr	4480	26	the	the	DT
cord-006860-a3b8hyyr	4480	27	classical	classical	JJ
cord-006860-a3b8hyyr	4480	28	adsorption	adsorption	NN
cord-006860-a3b8hyyr	4480	29	to	to	IN
cord-006860-a3b8hyyr	4480	30	barium	barium	NN
cord-006860-a3b8hyyr	4480	31	sulphate	sulphate	NN
cord-006860-a3b8hyyr	4480	32	or	or	CC
cord-006860-a3b8hyyr	4480	33	aluminum	aluminum	NN
cord-006860-a3b8hyyr	4480	34	hydroxide	hydroxide	NN
cord-006860-a3b8hyyr	4480	35	from	from	IN
cord-006860-a3b8hyyr	4480	36	human	human	JJ
cord-006860-a3b8hyyr	4480	37	plasma	plasma	NN
cord-006860-a3b8hyyr	4480	38	can	can	MD
cord-006860-a3b8hyyr	4480	39	not	not	RB
cord-006860-a3b8hyyr	4480	40	be	be	VB
cord-006860-a3b8hyyr	4480	41	used	use	VBN
cord-006860-a3b8hyyr	4480	42	.	.	.
cord-006860-a3b8hyyr	4481	1	Commercially	commercially	RB
cord-006860-a3b8hyyr	4481	2	available	available	JJ
cord-006860-a3b8hyyr	4481	3	human	human	JJ
cord-006860-a3b8hyyr	4481	4	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4481	5	is	be	VBZ
cord-006860-a3b8hyyr	4481	6	expensive	expensive	JJ
cord-006860-a3b8hyyr	4481	7	and	and	CC
cord-006860-a3b8hyyr	4481	8	of	of	IN
cord-006860-a3b8hyyr	4481	9	an	an	DT
cord-006860-a3b8hyyr	4481	10	unacceptable	unacceptable	JJ
cord-006860-a3b8hyyr	4481	11	quality	quality	NN
cord-006860-a3b8hyyr	4481	12	for	for	IN
cord-006860-a3b8hyyr	4481	13	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4481	14	applications	application	NNS
cord-006860-a3b8hyyr	4481	15	.	.	.
cord-006860-a3b8hyyr	4482	1	In	in	IN
cord-006860-a3b8hyyr	4482	2	most	most	JJS
cord-006860-a3b8hyyr	4482	3	of	of	IN
cord-006860-a3b8hyyr	4482	4	these	these	DT
cord-006860-a3b8hyyr	4482	5	batches	batch	NNS
cord-006860-a3b8hyyr	4482	6	we	-PRON-	PRP
cord-006860-a3b8hyyr	4482	7	found	find	VBD
cord-006860-a3b8hyyr	4482	8	small	small	JJ
cord-006860-a3b8hyyr	4482	9	amounts	amount	NNS
cord-006860-a3b8hyyr	4482	10	of	of	IN
cord-006860-a3b8hyyr	4482	11	Factor	factor	NN
cord-006860-a3b8hyyr	4482	12	X	X	NNP
cord-006860-a3b8hyyr	4482	13	and	and	CC
cord-006860-a3b8hyyr	4482	14	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4482	15	activation	activation	NN
cord-006860-a3b8hyyr	4482	16	products	product	NNS
cord-006860-a3b8hyyr	4482	17	.	.	.
cord-006860-a3b8hyyr	4483	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4483	2	now	now	RB
cord-006860-a3b8hyyr	4483	3	developed	develop	VBD
cord-006860-a3b8hyyr	4483	4	a	a	DT
cord-006860-a3b8hyyr	4483	5	procedure	procedure	NN
cord-006860-a3b8hyyr	4483	6	to	to	TO
cord-006860-a3b8hyyr	4483	7	isolate	isolate	VB
cord-006860-a3b8hyyr	4483	8	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4483	9	from	from	IN
cord-006860-a3b8hyyr	4483	10	"	"	``
cord-006860-a3b8hyyr	4483	11	Prothrombin	Prothrombin	NNP
cord-006860-a3b8hyyr	4483	12	Complex	Complex	NNP
cord-006860-a3b8hyyr	4483	13	Concentrates	Concentrates	NNPS
cord-006860-a3b8hyyr	4483	14	"	"	''
cord-006860-a3b8hyyr	4483	15	(	(	-LRB-
cord-006860-a3b8hyyr	4483	16	PPSB-250-bulk	PPSB-250-bulk	NNP
cord-006860-a3b8hyyr	4483	17	,	,	,
cord-006860-a3b8hyyr	4483	18	DRK	DRK	NNP
cord-006860-a3b8hyyr	4483	19	-	-	HYPH
cord-006860-a3b8hyyr	4483	20	Blutspendedienst	Blutspendedienst	NNP
cord-006860-a3b8hyyr	4483	21	Nds	Nds	NNP
cord-006860-a3b8hyyr	4483	22	.	.	.
cord-006860-a3b8hyyr	4483	23	)	)	-RRB-
cord-006860-a3b8hyyr	4483	24	.	.	.
cord-006860-a3b8hyyr	4484	1	The	the	DT
cord-006860-a3b8hyyr	4484	2	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4484	3	also	also	RB
cord-006860-a3b8hyyr	4484	4	contains	contain	VBZ
cord-006860-a3b8hyyr	4484	5	fac	fac	NN
cord-006860-a3b8hyyr	4484	6	-	-	HYPH
cord-006860-a3b8hyyr	4484	7	tor	tor	NN
cord-006860-a3b8hyyr	4484	8	VII	vii	NN
cord-006860-a3b8hyyr	4484	9	,	,	,
cord-006860-a3b8hyyr	4484	10	factor	factor	NN
cord-006860-a3b8hyyr	4484	11	IX	ix	NN
cord-006860-a3b8hyyr	4484	12	,	,	,
cord-006860-a3b8hyyr	4484	13	and	and	CC
cord-006860-a3b8hyyr	4484	14	factor	factor	NN
cord-006860-a3b8hyyr	4484	15	X.	x.	NN
cord-006860-a3b8hyyr	4485	1	The	the	DT
cord-006860-a3b8hyyr	4485	2	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4485	3	had	have	VBD
cord-006860-a3b8hyyr	4485	4	to	to	TO
cord-006860-a3b8hyyr	4485	5	be	be	VB
cord-006860-a3b8hyyr	4485	6	separated	separate	VBN
cord-006860-a3b8hyyr	4485	7	from	from	IN
cord-006860-a3b8hyyr	4485	8	these	these	DT
cord-006860-a3b8hyyr	4485	9	factors	factor	NNS
cord-006860-a3b8hyyr	4485	10	.	.	.
cord-006860-a3b8hyyr	4486	1	The	the	DT
cord-006860-a3b8hyyr	4486	2	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4486	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	4486	4	used	use	VBD
cord-006860-a3b8hyyr	4486	5	contained	contain	VBD
cord-006860-a3b8hyyr	4486	6	amounts	amount	NNS
cord-006860-a3b8hyyr	4486	7	of	of	IN
cord-006860-a3b8hyyr	4486	8	other	other	JJ
cord-006860-a3b8hyyr	4486	9	proteins	protein	NNS
cord-006860-a3b8hyyr	4486	10	and	and	CC
cord-006860-a3b8hyyr	4486	11	activation	activation	NN
cord-006860-a3b8hyyr	4486	12	products	product	NNS
cord-006860-a3b8hyyr	4486	13	of	of	IN
cord-006860-a3b8hyyr	4486	14	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4486	15	(	(	-LRB-
cord-006860-a3b8hyyr	4486	16	e.g.	e.g.	RB
cord-006860-a3b8hyyr	4486	17	prethrombin-1	prethrombin-1	NNP
cord-006860-a3b8hyyr	4486	18	)	)	-RRB-
cord-006860-a3b8hyyr	4486	19	as	as	RB
cord-006860-a3b8hyyr	4486	20	well	well	RB
cord-006860-a3b8hyyr	4486	21	.	.	.
cord-006860-a3b8hyyr	4487	1	For	for	IN
cord-006860-a3b8hyyr	4487	2	the	the	DT
cord-006860-a3b8hyyr	4487	3	preparation	preparation	NN
cord-006860-a3b8hyyr	4487	4	of	of	IN
cord-006860-a3b8hyyr	4487	5	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4487	6	from	from	IN
cord-006860-a3b8hyyr	4487	7	PPSB	PPSB	NNP
cord-006860-a3b8hyyr	4487	8	we	-PRON-	PRP
cord-006860-a3b8hyyr	4487	9	used	use	VBD
cord-006860-a3b8hyyr	4487	10	anion	anion	NN
cord-006860-a3b8hyyr	4487	11	exchangechromatography	exchangechromatography	NN
cord-006860-a3b8hyyr	4488	1	(	(	-LRB-
cord-006860-a3b8hyyr	4488	2	Resource	resource	NN
cord-006860-a3b8hyyr	4488	3	-	-	HYPH
cord-006860-a3b8hyyr	4488	4	Q	Q	NNP
cord-006860-a3b8hyyr	4488	5	®	®	NNP
cord-006860-a3b8hyyr	4488	6	)	)	-RRB-
cord-006860-a3b8hyyr	4488	7	on	on	IN
cord-006860-a3b8hyyr	4488	8	an	an	DT
cord-006860-a3b8hyyr	4488	9	FPLC	FPLC	NNP
cord-006860-a3b8hyyr	4488	10	®	®	NN
cord-006860-a3b8hyyr	4488	11	.	.	.
cord-006860-a3b8hyyr	4489	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4489	2	applied	apply	VBD
cord-006860-a3b8hyyr	4489	3	dissolved	dissolve	VBN
cord-006860-a3b8hyyr	4489	4	PPSB	PPSB	NNP
cord-006860-a3b8hyyr	4489	5	directly	directly	RB
cord-006860-a3b8hyyr	4489	6	or	or	CC
cord-006860-a3b8hyyr	4489	7	after	after	IN
cord-006860-a3b8hyyr	4489	8	buffer	buffer	NN
cord-006860-a3b8hyyr	4489	9	exchange	exchange	NN
cord-006860-a3b8hyyr	4489	10	on	on	IN
cord-006860-a3b8hyyr	4489	11	Sephadex	Sephadex	NNP
cord-006860-a3b8hyyr	4489	12	G-25	G-25	NNP
cord-006860-a3b8hyyr	4489	13	onto	onto	IN
cord-006860-a3b8hyyr	4489	14	the	the	DT
cord-006860-a3b8hyyr	4489	15	column	column	NN
cord-006860-a3b8hyyr	4489	16	at	at	IN
cord-006860-a3b8hyyr	4489	17	room	room	NN
cord-006860-a3b8hyyr	4489	18	temperature	temperature	NN
cord-006860-a3b8hyyr	4489	19	.	.	.
cord-006860-a3b8hyyr	4490	1	The	the	DT
cord-006860-a3b8hyyr	4490	2	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4490	3	was	be	VBD
cord-006860-a3b8hyyr	4490	4	eluted	elute	VBN
cord-006860-a3b8hyyr	4490	5	with	with	IN
cord-006860-a3b8hyyr	4490	6	an	an	DT
cord-006860-a3b8hyyr	4490	7	NaCI	naci	NN
cord-006860-a3b8hyyr	4490	8	-	-	HYPH
cord-006860-a3b8hyyr	4490	9	gradient	gradient	NN
cord-006860-a3b8hyyr	4490	10	in	in	IN
cord-006860-a3b8hyyr	4490	11	trisodium	trisodium	NNP
cord-006860-a3b8hyyr	4490	12	citrate	citrate	NNP
cord-006860-a3b8hyyr	4490	13	buffer	buffer	NN
cord-006860-a3b8hyyr	4490	14	,	,	,
cord-006860-a3b8hyyr	4490	15	pH	pH	NNP
cord-006860-a3b8hyyr	4490	16	7.0	7.0	CD
cord-006860-a3b8hyyr	4490	17	.	.	.
cord-006860-a3b8hyyr	4491	1	The	the	DT
cord-006860-a3b8hyyr	4491	2	buffer	buffer	NN
cord-006860-a3b8hyyr	4491	3	conditions	condition	NNS
cord-006860-a3b8hyyr	4491	4	are	be	VBP
cord-006860-a3b8hyyr	4491	5	similar	similar	JJ
cord-006860-a3b8hyyr	4491	6	to	to	IN
cord-006860-a3b8hyyr	4491	7	the	the	DT
cord-006860-a3b8hyyr	4491	8	conditions	condition	NNS
cord-006860-a3b8hyyr	4491	9	used	use	VBN
cord-006860-a3b8hyyr	4491	10	in	in	IN
cord-006860-a3b8hyyr	4491	11	the	the	DT
cord-006860-a3b8hyyr	4491	12	preparation	preparation	NN
cord-006860-a3b8hyyr	4491	13	of	of	IN
cord-006860-a3b8hyyr	4491	14	PPSB	PPSB	NNP
cord-006860-a3b8hyyr	4491	15	.	.	.
cord-006860-a3b8hyyr	4492	1	The	the	DT
cord-006860-a3b8hyyr	4492	2	quality	quality	NN
cord-006860-a3b8hyyr	4492	3	of	of	IN
cord-006860-a3b8hyyr	4492	4	the	the	DT
cord-006860-a3b8hyyr	4492	5	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4492	6	so	so	RB
cord-006860-a3b8hyyr	4492	7	obtained	obtain	VBN
cord-006860-a3b8hyyr	4492	8	was	be	VBD
cord-006860-a3b8hyyr	4492	9	sufficient	sufficient	JJ
cord-006860-a3b8hyyr	4492	10	for	for	IN
cord-006860-a3b8hyyr	4492	11	most	most	JJS
cord-006860-a3b8hyyr	4492	12	of	of	IN
cord-006860-a3b8hyyr	4492	13	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4492	14	experiments	experiment	NNS
cord-006860-a3b8hyyr	4492	15	.	.	.
cord-006860-a3b8hyyr	4493	1	A	a	DT
cord-006860-a3b8hyyr	4493	2	second	second	JJ
cord-006860-a3b8hyyr	4493	3	purification	purification	NN
cord-006860-a3b8hyyr	4493	4	step	step	NN
cord-006860-a3b8hyyr	4493	5	on	on	IN
cord-006860-a3b8hyyr	4493	6	ion	ion	NN
cord-006860-a3b8hyyr	4493	7	-	-	HYPH
cord-006860-a3b8hyyr	4493	8	exchange	exchange	NN
cord-006860-a3b8hyyr	4493	9	resulted	result	VBD
cord-006860-a3b8hyyr	4493	10	in	in	IN
cord-006860-a3b8hyyr	4493	11	a	a	DT
cord-006860-a3b8hyyr	4493	12	99	99	CD
cord-006860-a3b8hyyr	4493	13	%	%	NN
cord-006860-a3b8hyyr	4493	14	pure	pure	JJ
cord-006860-a3b8hyyr	4493	15	product	product	NN
cord-006860-a3b8hyyr	4493	16	devoid	devoid	JJ
cord-006860-a3b8hyyr	4493	17	of	of	IN
cord-006860-a3b8hyyr	4493	18	contaminating	contaminate	VBG
cord-006860-a3b8hyyr	4493	19	factor	factor	NN
cord-006860-a3b8hyyr	4493	20	activities	activity	NNS
cord-006860-a3b8hyyr	4493	21	and	and	CC
cord-006860-a3b8hyyr	4493	22	activation	activation	NN
cord-006860-a3b8hyyr	4493	23	intermediates	intermediate	NNS
cord-006860-a3b8hyyr	4493	24	as	as	IN
cord-006860-a3b8hyyr	4493	25	examined	examine	VBN
cord-006860-a3b8hyyr	4493	26	with	with	IN
cord-006860-a3b8hyyr	4493	27	coomassie	coomassie	NN
cord-006860-a3b8hyyr	4493	28	and	and	CC
cord-006860-a3b8hyyr	4493	29	silver	silver	NN
cord-006860-a3b8hyyr	4493	30	stained	stain	VBN
cord-006860-a3b8hyyr	4493	31	SDS	SDS	NNP
cord-006860-a3b8hyyr	4493	32	-	-	HYPH
cord-006860-a3b8hyyr	4493	33	Page	page	NN
cord-006860-a3b8hyyr	4493	34	electrophoresis	electrophoresis	NN
cord-006860-a3b8hyyr	4493	35	and	and	CC
cord-006860-a3b8hyyr	4493	36	assays	assay	NNS
cord-006860-a3b8hyyr	4493	37	for	for	IN
cord-006860-a3b8hyyr	4493	38	Factor	factor	NN
cord-006860-a3b8hyyr	4493	39	X.	X.	NNP
cord-006860-a3b8hyyr	4494	1	This	this	DT
cord-006860-a3b8hyyr	4494	2	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4494	3	contained	contain	VBD
cord-006860-a3b8hyyr	4494	4	full	full	JJ
cord-006860-a3b8hyyr	4494	5	enzymatic	enzymatic	JJ
cord-006860-a3b8hyyr	4494	6	activity	activity	NN
cord-006860-a3b8hyyr	4494	7	and	and	CC
cord-006860-a3b8hyyr	4494	8	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4494	9	activation	activation	NN
cord-006860-a3b8hyyr	4494	10	by	by	IN
cord-006860-a3b8hyyr	4494	11	specific	specific	JJ
cord-006860-a3b8hyyr	4494	12	snake	snake	NN
cord-006860-a3b8hyyr	4494	13	venom	venom	NN
cord-006860-a3b8hyyr	4494	14	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4494	15	activators	activator	NNS
cord-006860-a3b8hyyr	4494	16	showed	show	VBD
cord-006860-a3b8hyyr	4494	17	the	the	DT
cord-006860-a3b8hyyr	4494	18	known	know	VBN
cord-006860-a3b8hyyr	4494	19	activation	activation	NN
cord-006860-a3b8hyyr	4494	20	products	product	NNS
cord-006860-a3b8hyyr	4494	21	.	.	.
cord-006860-a3b8hyyr	4495	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4495	2	are	be	VBP
cord-006860-a3b8hyyr	4495	3	now	now	RB
cord-006860-a3b8hyyr	4495	4	able	able	JJ
cord-006860-a3b8hyyr	4495	5	to	to	TO
cord-006860-a3b8hyyr	4495	6	isolate	isolate	VB
cord-006860-a3b8hyyr	4495	7	the	the	DT
cord-006860-a3b8hyyr	4495	8	amounts	amount	NNS
cord-006860-a3b8hyyr	4495	9	of	of	IN
cord-006860-a3b8hyyr	4495	10	pure	pure	JJ
cord-006860-a3b8hyyr	4495	11	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4495	12	required	require	VBN
cord-006860-a3b8hyyr	4495	13	for	for	IN
cord-006860-a3b8hyyr	4495	14	preclinical	preclinical	JJ
cord-006860-a3b8hyyr	4495	15	investigations	investigation	NNS
cord-006860-a3b8hyyr	4495	16	.	.	.
cord-006860-a3b8hyyr	4496	1	Most	Most	JJS
cord-006860-a3b8hyyr	4496	2	of	of	IN
cord-006860-a3b8hyyr	4496	3	the	the	DT
cord-006860-a3b8hyyr	4496	4	commercially	commercially	RB
cord-006860-a3b8hyyr	4496	5	available	available	JJ
cord-006860-a3b8hyyr	4496	6	LMWHs	lmwh	NNS
cord-006860-a3b8hyyr	4496	7	such	such	JJ
cord-006860-a3b8hyyr	4496	8	as	as	IN
cord-006860-a3b8hyyr	4496	9	Enoxaparin	Enoxaparin	NNP
cord-006860-a3b8hyyr	4496	10	,	,	,
cord-006860-a3b8hyyr	4496	11	Fraxiparin	Fraxiparin	NNP
cord-006860-a3b8hyyr	4496	12	,	,	,
cord-006860-a3b8hyyr	4496	13	and	and	CC
cord-006860-a3b8hyyr	4496	14	Fragrnin	Fragrnin	NNP
cord-006860-a3b8hyyr	4496	15	are	be	VBP
cord-006860-a3b8hyyr	4496	16	prepared	prepare	VBN
cord-006860-a3b8hyyr	4496	17	by	by	IN
cord-006860-a3b8hyyr	4496	18	chemical	chemical	JJ
cord-006860-a3b8hyyr	4496	19	methods	method	NNS
cord-006860-a3b8hyyr	4496	20	which	which	WDT
cord-006860-a3b8hyyr	4496	21	can	can	MD
cord-006860-a3b8hyyr	4496	22	result	result	VB
cord-006860-a3b8hyyr	4496	23	in	in	IN
cord-006860-a3b8hyyr	4496	24	desulfation	desulfation	NN
cord-006860-a3b8hyyr	4496	25	and	and	CC
cord-006860-a3b8hyyr	4496	26	other	other	JJ
cord-006860-a3b8hyyr	4496	27	chemical	chemical	JJ
cord-006860-a3b8hyyr	4496	28	modifications	modification	NNS
cord-006860-a3b8hyyr	4496	29	of	of	IN
cord-006860-a3b8hyyr	4496	30	the	the	DT
cord-006860-a3b8hyyr	4496	31	internal	internal	JJ
cord-006860-a3b8hyyr	4496	32	structure	structure	NN
cord-006860-a3b8hyyr	4496	33	leading	lead	VBG
cord-006860-a3b8hyyr	4496	34	to	to	IN
cord-006860-a3b8hyyr	4496	35	differences	difference	NNS
cord-006860-a3b8hyyr	4496	36	in	in	IN
cord-006860-a3b8hyyr	4496	37	the	the	DT
cord-006860-a3b8hyyr	4496	38	pharmacologic	pharmacologic	JJ
cord-006860-a3b8hyyr	4496	39	effects	effect	NNS
cord-006860-a3b8hyyr	4496	40	.	.	.
cord-006860-a3b8hyyr	4497	1	On	on	IN
cord-006860-a3b8hyyr	4497	2	the	the	DT
cord-006860-a3b8hyyr	4497	3	other	other	JJ
cord-006860-a3b8hyyr	4497	4	hand	hand	NN
cord-006860-a3b8hyyr	4497	5	,	,	,
cord-006860-a3b8hyyr	4497	6	tiactionated	tiactionated	NNP
cord-006860-a3b8hyyr	4497	7	LMWHs	LMWHs	NNPS
cord-006860-a3b8hyyr	4497	8	retain	retain	VBP
cord-006860-a3b8hyyr	4497	9	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4497	10	native	native	JJ
cord-006860-a3b8hyyr	4497	11	characteristics	characteristic	NNS
cord-006860-a3b8hyyr	4497	12	and	and	CC
cord-006860-a3b8hyyr	4497	13	are	be	VBP
cord-006860-a3b8hyyr	4497	14	structurally	structurally	RB
cord-006860-a3b8hyyr	4497	15	similar	similar	JJ
cord-006860-a3b8hyyr	4497	16	to	to	IN
cord-006860-a3b8hyyr	4497	17	heparin	heparin	NN
cord-006860-a3b8hyyr	4497	18	.	.	.
cord-006860-a3b8hyyr	4498	1	In	in	IN
cord-006860-a3b8hyyr	4498	2	addition	addition	NN
cord-006860-a3b8hyyr	4498	3	,	,	,
cord-006860-a3b8hyyr	4498	4	the	the	DT
cord-006860-a3b8hyyr	4498	5	oligosaocharide	oligosaocharide	NN
cord-006860-a3b8hyyr	4498	6	sequence	sequence	NN
cord-006860-a3b8hyyr	4498	7	responsible	responsible	JJ
cord-006860-a3b8hyyr	4498	8	for	for	IN
cord-006860-a3b8hyyr	4498	9	ATIII	ATIII	NNP
cord-006860-a3b8hyyr	4498	10	binding	binding	NN
cord-006860-a3b8hyyr	4498	11	is	be	VBZ
cord-006860-a3b8hyyr	4498	12	not	not	RB
cord-006860-a3b8hyyr	4498	13	modified	modify	VBN
cord-006860-a3b8hyyr	4498	14	.	.	.
cord-006860-a3b8hyyr	4499	1	Physical	physical	JJ
cord-006860-a3b8hyyr	4499	2	methods	method	NNS
cord-006860-a3b8hyyr	4499	3	such	such	JJ
cord-006860-a3b8hyyr	4499	4	as	as	IN
cord-006860-a3b8hyyr	4499	5	gamma	gamma	NN
cord-006860-a3b8hyyr	4499	6	irradiation	irradiation	NN
cord-006860-a3b8hyyr	4499	7	(	(	-LRB-
cord-006860-a3b8hyyr	4499	8	~Co	~co	JJ
cord-006860-a3b8hyyr	4499	9	)	)	-RRB-
cord-006860-a3b8hyyr	4499	10	have	have	VBP
cord-006860-a3b8hyyr	4499	11	been	be	VBN
cord-006860-a3b8hyyr	4499	12	used	use	VBN
cord-006860-a3b8hyyr	4499	13	to	to	IN
cord-006860-a3b8hyyr	4499	14	fi'agment	fi'agment	NNP
cord-006860-a3b8hyyr	4499	15	sulfated	sulfated	JJ
cord-006860-a3b8hyyr	4499	16	glycosaminoglyeans	glycosaminoglyeans	XX
cord-006860-a3b8hyyr	4499	17	yielding	yield	VBG
cord-006860-a3b8hyyr	4499	18	fragraents	fragraent	NNS
cord-006860-a3b8hyyr	4499	19	without	without	IN
cord-006860-a3b8hyyr	4499	20	chemical	chemical	NN
cord-006860-a3b8hyyr	4499	21	modifications	modification	NNS
cord-006860-a3b8hyyr	4499	22	(	(	-LRB-
cord-006860-a3b8hyyr	4499	23	DeAmbrosi	DeAmbrosi	NNP
cord-006860-a3b8hyyr	4499	24	et	et	FW
cord-006860-a3b8hyyr	4499	25	at	at	IN
cord-006860-a3b8hyyr	4499	26	.	.	.
cord-006860-a3b8hyyr	4500	1	In	in	IN
cord-006860-a3b8hyyr	4500	2	:	:	:
cord-006860-a3b8hyyr	4500	3	Biomedical	Biomedical	NNP
cord-006860-a3b8hyyr	4500	4	and	and	CC
cord-006860-a3b8hyyr	4500	5	Biotechnological	Biotechnological	NNP
cord-006860-a3b8hyyr	4500	6	Advances	Advances	NNPS
cord-006860-a3b8hyyr	4500	7	in	in	IN
cord-006860-a3b8hyyr	4500	8	Industrial	Industrial	NNP
cord-006860-a3b8hyyr	4500	9	Polysaccharides	Polysaccharides	NNP
cord-006860-a3b8hyyr	4500	10	,	,	,
cord-006860-a3b8hyyr	4500	11	pp	pp	NNP
cord-006860-a3b8hyyr	4500	12	.	.	.
cord-006860-a3b8hyyr	4501	1	45	45	CD
cord-006860-a3b8hyyr	4501	2	-	-	SYM
cord-006860-a3b8hyyr	4501	3	53	53	CD
cord-006860-a3b8hyyr	4501	4	)	)	-RRB-
cord-006860-a3b8hyyr	4501	5	.	.	.
cord-006860-a3b8hyyr	4502	1	Utilizing	utilize	VBG
cord-006860-a3b8hyyr	4502	2	this	this	DT
cord-006860-a3b8hyyr	4502	3	technique	technique	NN
cord-006860-a3b8hyyr	4502	4	,	,	,
cord-006860-a3b8hyyr	4502	5	depolymerized	depolymerized	JJ
cord-006860-a3b8hyyr	4502	6	heparius	heparius	NNP
cord-006860-a3b8hyyr	4502	7	exhibiting	exhibit	VBG
cord-006860-a3b8hyyr	4502	8	different	different	JJ
cord-006860-a3b8hyyr	4502	9	molecular	molecular	JJ
cord-006860-a3b8hyyr	4502	10	weights	weight	NNS
cord-006860-a3b8hyyr	4502	11	can	can	MD
cord-006860-a3b8hyyr	4502	12	be	be	VB
cord-006860-a3b8hyyr	4502	13	obtained	obtain	VBN
cord-006860-a3b8hyyr	4502	14	.	.	.
cord-006860-a3b8hyyr	4503	1	This	this	DT
cord-006860-a3b8hyyr	4503	2	communication	communication	NN
cord-006860-a3b8hyyr	4503	3	reports	report	VBZ
cord-006860-a3b8hyyr	4503	4	on	on	IN
cord-006860-a3b8hyyr	4503	5	the	the	DT
cord-006860-a3b8hyyr	4503	6	biochemical	biochemical	JJ
cord-006860-a3b8hyyr	4503	7	and	and	CC
cord-006860-a3b8hyyr	4503	8	pharmacologic	pharmacologic	JJ
cord-006860-a3b8hyyr	4503	9	effects	effect	NNS
cord-006860-a3b8hyyr	4503	10	of	of	IN
cord-006860-a3b8hyyr	4503	11	several	several	JJ
cord-006860-a3b8hyyr	4503	12	such	such	JJ
cord-006860-a3b8hyyr	4503	13	depolymerized	depolymerized	JJ
cord-006860-a3b8hyyr	4503	14	heparins	heparin	NNS
cord-006860-a3b8hyyr	4503	15	to	to	TO
cord-006860-a3b8hyyr	4503	16	demonstrate	demonstrate	VB
cord-006860-a3b8hyyr	4503	17	the	the	DT
cord-006860-a3b8hyyr	4503	18	molecular	molecular	JJ
cord-006860-a3b8hyyr	4503	19	weight	weight	NN
cord-006860-a3b8hyyr	4503	20	dependence	dependence	NN
cord-006860-a3b8hyyr	4503	21	on	on	IN
cord-006860-a3b8hyyr	4503	22	biologic	biologic	JJ
cord-006860-a3b8hyyr	4503	23	activity	activity	NN
cord-006860-a3b8hyyr	4503	24	.	.	.
cord-006860-a3b8hyyr	4504	1	Fragments	fragment	NNS
cord-006860-a3b8hyyr	4504	2	exhibiting	exhibit	VBG
cord-006860-a3b8hyyr	4504	3	molecular	molecular	JJ
cord-006860-a3b8hyyr	4504	4	weights	weight	NNS
cord-006860-a3b8hyyr	4504	5	of	of	IN
cord-006860-a3b8hyyr	4504	6	5	5	CD
cord-006860-a3b8hyyr	4504	7	,	,	,
cord-006860-a3b8hyyr	4504	8	7	7	CD
cord-006860-a3b8hyyr	4504	9	,	,	,
cord-006860-a3b8hyyr	4504	10	8	8	CD
cord-006860-a3b8hyyr	4504	11	,	,	,
cord-006860-a3b8hyyr	4504	12	and	and	CC
cord-006860-a3b8hyyr	4504	13	9	9	CD
cord-006860-a3b8hyyr	4504	14	kDa	kDa	NNS
cord-006860-a3b8hyyr	4504	15	were	be	VBD
cord-006860-a3b8hyyr	4504	16	prepared	prepare	VBN
cord-006860-a3b8hyyr	4504	17	by	by	IN
cord-006860-a3b8hyyr	4504	18	exposing	expose	VBG
cord-006860-a3b8hyyr	4504	19	concentrated	concentrate	VBN
cord-006860-a3b8hyyr	4504	20	heparin	heparin	JJ
cord-006860-a3b8hyyr	4504	21	solutions	solution	NNS
cord-006860-a3b8hyyr	4504	22	to	to	IN
cord-006860-a3b8hyyr	4504	23	a	a	DT
cord-006860-a3b8hyyr	4504	24	rectilinear	rectilinear	JJ
cord-006860-a3b8hyyr	4504	25	gamma	gamma	NN
cord-006860-a3b8hyyr	4504	26	ray	ray	NN
cord-006860-a3b8hyyr	4504	27	beam	beam	NN
cord-006860-a3b8hyyr	4504	28	at	at	IN
cord-006860-a3b8hyyr	4504	29	intermittent	intermittent	JJ
cord-006860-a3b8hyyr	4504	30	doses	dose	NNS
cord-006860-a3b8hyyr	4504	31	of	of	IN
cord-006860-a3b8hyyr	4504	32	2.5	2.5	CD
cord-006860-a3b8hyyr	4504	33	to	to	TO
cord-006860-a3b8hyyr	4504	34	25	25	CD
cord-006860-a3b8hyyr	4504	35	Mrad	Mrad	NNP
cord-006860-a3b8hyyr	4504	36	under	under	IN
cord-006860-a3b8hyyr	4504	37	controlled	control	VBN
cord-006860-a3b8hyyr	4504	38	temperatures	temperature	NNS
cord-006860-a3b8hyyr	4504	39	.	.	.
cord-006860-a3b8hyyr	4505	1	Unlike	unlike	IN
cord-006860-a3b8hyyr	4505	2	the	the	DT
cord-006860-a3b8hyyr	4505	3	chemically	chemically	RB
cord-006860-a3b8hyyr	4505	4	depolymerized	depolymerize	VBN
cord-006860-a3b8hyyr	4505	5	heparins	heparin	NNS
cord-006860-a3b8hyyr	4505	6	,	,	,
cord-006860-a3b8hyyr	4505	7	these	these	DT
cord-006860-a3b8hyyr	4505	8	fractions	fraction	NNS
cord-006860-a3b8hyyr	4505	9	did	do	VBD
cord-006860-a3b8hyyr	4505	10	not	not	RB
cord-006860-a3b8hyyr	4505	11	exhibit	exhibit	VB
cord-006860-a3b8hyyr	4505	12	any	any	DT
cord-006860-a3b8hyyr	4505	13	decrease	decrease	NN
cord-006860-a3b8hyyr	4505	14	in	in	IN
cord-006860-a3b8hyyr	4505	15	charge	charge	NN
cord-006860-a3b8hyyr	4505	16	density	density	NN
cord-006860-a3b8hyyr	4505	17	or	or	CC
cord-006860-a3b8hyyr	4505	18	ATIII	ATIII	NNP
cord-006860-a3b8hyyr	4505	19	affinity	affinity	NN
cord-006860-a3b8hyyr	4505	20	.	.	.
cord-006860-a3b8hyyr	4506	1	In	in	IN
cord-006860-a3b8hyyr	4506	2	routine	routine	JJ
cord-006860-a3b8hyyr	4506	3	assays	assay	NNS
cord-006860-a3b8hyyr	4506	4	for	for	IN
cord-006860-a3b8hyyr	4506	5	heparin	heparin	NN
cord-006860-a3b8hyyr	4506	6	,	,	,
cord-006860-a3b8hyyr	4506	7	a	a	DT
cord-006860-a3b8hyyr	4506	8	clear	clear	JJ
cord-006860-a3b8hyyr	4506	9	cut	cut	VBN
cord-006860-a3b8hyyr	4506	10	molecular	molecular	JJ
cord-006860-a3b8hyyr	4506	11	weight	weight	NN
cord-006860-a3b8hyyr	4506	12	dependance	dependance	NN
cord-006860-a3b8hyyr	4506	13	on	on	IN
cord-006860-a3b8hyyr	4506	14	the	the	DT
cord-006860-a3b8hyyr	4506	15	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	4506	16	and	and	CC
cord-006860-a3b8hyyr	4506	17	antiprotease	antiprotease	NN
cord-006860-a3b8hyyr	4506	18	actions	action	NNS
cord-006860-a3b8hyyr	4506	19	was	be	VBD
cord-006860-a3b8hyyr	4506	20	observed	observe	VBN
cord-006860-a3b8hyyr	4506	21	.	.	.
cord-006860-a3b8hyyr	4507	1	On	on	IN
cord-006860-a3b8hyyr	4507	2	a	a	DT
cord-006860-a3b8hyyr	4507	3	gravimetric	gravimetric	JJ
cord-006860-a3b8hyyr	4507	4	basis	basis	NN
cord-006860-a3b8hyyr	4507	5	,	,	,
cord-006860-a3b8hyyr	4507	6	these	these	DT
cord-006860-a3b8hyyr	4507	7	agents	agent	NNS
cord-006860-a3b8hyyr	4507	8	produce	produce	VBP
cord-006860-a3b8hyyr	4507	9	superior	superior	JJ
cord-006860-a3b8hyyr	4507	10	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	4507	11	actions	action	NNS
cord-006860-a3b8hyyr	4507	12	in	in	IN
cord-006860-a3b8hyyr	4507	13	comparison	comparison	NN
cord-006860-a3b8hyyr	4507	14	to	to	TO
cord-006860-a3b8hyyr	4507	15	chemically	chemically	RB
cord-006860-a3b8hyyr	4507	16	depolymerized	depolymerize	VBN
cord-006860-a3b8hyyr	4507	17	derivatives	derivative	NNS
cord-006860-a3b8hyyr	4507	18	.	.	.
cord-006860-a3b8hyyr	4508	1	These	these	DT
cord-006860-a3b8hyyr	4508	2	studies	study	NNS
cord-006860-a3b8hyyr	4508	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	4508	4	that	that	IN
cord-006860-a3b8hyyr	4508	5	gamma	gamma	NN
cord-006860-a3b8hyyr	4508	6	irradiation	irradiation	NN
cord-006860-a3b8hyyr	4508	7	can	can	MD
cord-006860-a3b8hyyr	4508	8	be	be	VB
cord-006860-a3b8hyyr	4508	9	used	use	VBN
cord-006860-a3b8hyyr	4508	10	to	to	TO
cord-006860-a3b8hyyr	4508	11	prepare	prepare	VB
cord-006860-a3b8hyyr	4508	12	LMWHs	lmwh	NNS
cord-006860-a3b8hyyr	4508	13	which	which	WDT
cord-006860-a3b8hyyr	4508	14	retain	retain	VBP
cord-006860-a3b8hyyr	4508	15	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4508	16	molecular	molecular	JJ
cord-006860-a3b8hyyr	4508	17	integrity	integrity	NN
cord-006860-a3b8hyyr	4508	18	and	and	CC
cord-006860-a3b8hyyr	4508	19	therefore	therefore	RB
cord-006860-a3b8hyyr	4508	20	may	may	MD
cord-006860-a3b8hyyr	4508	21	prove	prove	VB
cord-006860-a3b8hyyr	4508	22	to	to	TO
cord-006860-a3b8hyyr	4508	23	exhibit	exhibit	VB
cord-006860-a3b8hyyr	4508	24	a	a	DT
cord-006860-a3b8hyyr	4508	25	more	more	RBR
cord-006860-a3b8hyyr	4508	26	comparable	comparable	JJ
cord-006860-a3b8hyyr	4508	27	biologic	biologic	JJ
cord-006860-a3b8hyyr	4508	28	profile	profile	NN
cord-006860-a3b8hyyr	4508	29	to	to	TO
cord-006860-a3b8hyyr	4508	30	hepari~	hepari~	VB
cord-006860-a3b8hyyr	4508	31	Futthermore	Futthermore	NNP
cord-006860-a3b8hyyr	4508	32	,	,	,
cord-006860-a3b8hyyr	4508	33	LMWHs	LMWHs	NNP
cord-006860-a3b8hyyr	4508	34	produced	produce	VBN
cord-006860-a3b8hyyr	4508	35	by	by	IN
cord-006860-a3b8hyyr	4508	36	gamma	gamma	NN
cord-006860-a3b8hyyr	4508	37	irradiation	irradiation	NN
cord-006860-a3b8hyyr	4509	1	lack	lack	VB
cord-006860-a3b8hyyr	4509	2	the	the	DT
cord-006860-a3b8hyyr	4509	3	usual	usual	JJ
cord-006860-a3b8hyyr	4509	4	double	double	JJ
cord-006860-a3b8hyyr	4509	5	bond	bond	NN
cord-006860-a3b8hyyr	4509	6	fommtion	fommtion	NN
cord-006860-a3b8hyyr	4509	7	which	which	WDT
cord-006860-a3b8hyyr	4509	8	requires	require	VBZ
cord-006860-a3b8hyyr	4509	9	the	the	DT
cord-006860-a3b8hyyr	4509	10	use	use	NN
cord-006860-a3b8hyyr	4509	11	of	of	IN
cord-006860-a3b8hyyr	4509	12	additives	additive	NNS
cord-006860-a3b8hyyr	4509	13	which	which	WDT
cord-006860-a3b8hyyr	4509	14	can	can	MD
cord-006860-a3b8hyyr	4509	15	alter	alter	VB
cord-006860-a3b8hyyr	4509	16	the	the	DT
cord-006860-a3b8hyyr	4509	17	product	product	NN
cord-006860-a3b8hyyr	4509	18	profile	profile	NN
cord-006860-a3b8hyyr	4509	19	.	.	.
cord-006860-a3b8hyyr	4510	1	University	University	NNP
cord-006860-a3b8hyyr	4510	2	Hospital	Hospital	NNP
cord-006860-a3b8hyyr	4510	3	,	,	,
cord-006860-a3b8hyyr	4510	4	Dept	Dept	NNP
cord-006860-a3b8hyyr	4510	5	.	.	NNP
cord-006860-a3b8hyyr	4510	6	of	of	IN
cord-006860-a3b8hyyr	4510	7	Angiology	Angiology	NNP
cord-006860-a3b8hyyr	4510	8	,	,	,
cord-006860-a3b8hyyr	4511	1	Frankfurt	Frankfurt	NNP
cord-006860-a3b8hyyr	4511	2	a.	a.	NN
cord-006860-a3b8hyyr	4512	1	M.	M.	NNP
cord-006860-a3b8hyyr	4513	1	,	,	,
cord-006860-a3b8hyyr	4513	2	Germany	Germany	NNP
cord-006860-a3b8hyyr	4513	3	Introduction	Introduction	NNP
cord-006860-a3b8hyyr	4513	4	:	:	:
cord-006860-a3b8hyyr	4514	1	Thromboembolic	Thromboembolic	NNP
cord-006860-a3b8hyyr	4514	2	disease	disease	NN
cord-006860-a3b8hyyr	4514	3	constitutes	constitute	VBZ
cord-006860-a3b8hyyr	4514	4	a	a	DT
cord-006860-a3b8hyyr	4514	5	major	major	JJ
cord-006860-a3b8hyyr	4514	6	clinical	clinical	JJ
cord-006860-a3b8hyyr	4514	7	problem	problem	NN
cord-006860-a3b8hyyr	4514	8	and	and	CC
cord-006860-a3b8hyyr	4514	9	among	among	IN
cord-006860-a3b8hyyr	4514	10	others	other	NNS
cord-006860-a3b8hyyr	4514	11	a	a	DT
cord-006860-a3b8hyyr	4514	12	defective	defective	JJ
cord-006860-a3b8hyyr	4514	13	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4514	14	system	system	NN
cord-006860-a3b8hyyr	4514	15	has	have	VBZ
cord-006860-a3b8hyyr	4514	16	been	be	VBN
cord-006860-a3b8hyyr	4514	17	suggested	suggest	VBN
cord-006860-a3b8hyyr	4514	18	as	as	IN
cord-006860-a3b8hyyr	4514	19	a	a	DT
cord-006860-a3b8hyyr	4514	20	predisposing	predisposing	JJ
cord-006860-a3b8hyyr	4514	21	factor	factor	NN
cord-006860-a3b8hyyr	4514	22	for	for	IN
cord-006860-a3b8hyyr	4514	23	the	the	DT
cord-006860-a3b8hyyr	4514	24	development	development	NN
cord-006860-a3b8hyyr	4514	25	of	of	IN
cord-006860-a3b8hyyr	4514	26	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4514	27	.	.	.
cord-006860-a3b8hyyr	4515	1	The	the	DT
cord-006860-a3b8hyyr	4515	2	plasma	plasma	NN
cord-006860-a3b8hyyr	4515	3	fibrinolytic	fibrinolytic	NN
cord-006860-a3b8hyyr	4515	4	system	system	NN
cord-006860-a3b8hyyr	4515	5	can	can	MD
cord-006860-a3b8hyyr	4515	6	be	be	VB
cord-006860-a3b8hyyr	4515	7	impaired	impair	VBN
cord-006860-a3b8hyyr	4515	8	by	by	IN
cord-006860-a3b8hyyr	4515	9	inherited	inherit	VBN
cord-006860-a3b8hyyr	4515	10	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	4515	11	of	of	IN
cord-006860-a3b8hyyr	4515	12	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4515	13	defective	defective	JJ
cord-006860-a3b8hyyr	4515	14	release	release	NN
cord-006860-a3b8hyyr	4515	15	from	from	IN
cord-006860-a3b8hyyr	4515	16	the	the	DT
cord-006860-a3b8hyyr	4515	17	wessel	wessel	NNP
cord-006860-a3b8hyyr	4515	18	wall	wall	NNP
cord-006860-a3b8hyyr	4515	19	tissue	tissue	NNP
cord-006860-a3b8hyyr	4515	20	plasminogen	plasminogen	NNP
cord-006860-a3b8hyyr	4515	21	activator	activator	NN
cord-006860-a3b8hyyr	4515	22	(	(	-LRB-
cord-006860-a3b8hyyr	4515	23	t	t	NNP
cord-006860-a3b8hyyr	4515	24	-	-	HYPH
cord-006860-a3b8hyyr	4515	25	P'A	P'A	NNP
cord-006860-a3b8hyyr	4515	26	)	)	-RRB-
cord-006860-a3b8hyyr	4515	27	or	or	CC
cord-006860-a3b8hyyr	4515	28	by	by	IN
cord-006860-a3b8hyyr	4515	29	high	high	JJ
cord-006860-a3b8hyyr	4515	30	ptusma	ptusma	NNS
cord-006860-a3b8hyyr	4515	31	levels	level	NNS
cord-006860-a3b8hyyr	4515	32	of	of	IN
cord-006860-a3b8hyyr	4515	33	regulatory	regulatory	JJ
cord-006860-a3b8hyyr	4515	34	proteins	protein	NNS
cord-006860-a3b8hyyr	4515	35	,	,	,
cord-006860-a3b8hyyr	4515	36	such	such	JJ
cord-006860-a3b8hyyr	4515	37	as	as	IN
cord-006860-a3b8hyyr	4515	38	plasmino-8en	plasmino-8en	NNP
cord-006860-a3b8hyyr	4515	39	.	.	.
cord-006860-a3b8hyyr	4516	1	activator	activator	NN
cord-006860-a3b8hyyr	4516	2	inhibilors	inhibilor	NNS
cord-006860-a3b8hyyr	4516	3	(	(	-LRB-
cord-006860-a3b8hyyr	4516	4	PAl	PAl	NNS
cord-006860-a3b8hyyr	4516	5	)	)	-RRB-
cord-006860-a3b8hyyr	4516	6	.	.	.
cord-006860-a3b8hyyr	4517	1	The	the	DT
cord-006860-a3b8hyyr	4517	2	aim	aim	NN
cord-006860-a3b8hyyr	4517	3	.......	.......	NFP
cord-006860-a3b8hyyr	4517	4	of	of	IN
cord-006860-a3b8hyyr	4517	5	the	the	DT
cord-006860-a3b8hyyr	4517	6	present	present	JJ
cord-006860-a3b8hyyr	4517	7	study	study	NN
cord-006860-a3b8hyyr	4517	8	w	w	NNP
cord-006860-a3b8hyyr	4517	9	~	~	NFP
cord-006860-a3b8hyyr	4517	10	s	s	NNP
cord-006860-a3b8hyyr	4517	11	to	to	TO
cord-006860-a3b8hyyr	4517	12	eshmate	eshmate	VB
cord-006860-a3b8hyyr	4517	13	the	the	DT
cord-006860-a3b8hyyr	4517	14	prevalence	prevalence	NN
cord-006860-a3b8hyyr	4517	15	of	of	IN
cord-006860-a3b8hyyr	4517	16	decreased	decrease	VBN
cord-006860-a3b8hyyr	4517	17	fibnnolyl~	fibnnolyl~	NNP
cord-006860-a3b8hyyr	4518	1	c	c	NNP
cord-006860-a3b8hyyr	4518	2	actwlty	actwlty	NNP
cord-006860-a3b8hyyr	4518	3	m	m	NNP
cord-006860-a3b8hyyr	4518	4	young	young	JJ
cord-006860-a3b8hyyr	4518	5	pLs	pLs	NNP
cord-006860-a3b8hyyr	4518	6	.	.	.
cord-006860-a3b8hyyr	4519	1	with	with	IN
cord-006860-a3b8hyyr	4519	2	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	4519	3	.	.	.
cord-006860-a3b8hyyr	4520	1	Patients	patient	NNS
cord-006860-a3b8hyyr	4520	2	:	:	:
cord-006860-a3b8hyyr	4521	1	A	a	DT
cord-006860-a3b8hyyr	4521	2	great	great	JJ
cord-006860-a3b8hyyr	4521	3	population	population	NN
cord-006860-a3b8hyyr	4521	4	of	of	IN
cord-006860-a3b8hyyr	4521	5	884	884	CD
cord-006860-a3b8hyyr	4521	6	pts	pt	NNS
cord-006860-a3b8hyyr	4521	7	.	.	.
cord-006860-a3b8hyyr	4522	1	(	(	-LRB-
cord-006860-a3b8hyyr	4522	2	fenmle	fenmle	NNP
cord-006860-a3b8hyyr	4522	3	478	478	CD
cord-006860-a3b8hyyr	4522	4	,	,	,
cord-006860-a3b8hyyr	4522	5	male	male	JJ
cord-006860-a3b8hyyr	4522	6	406	406	CD
cord-006860-a3b8hyyr	4522	7	;	;	:
cord-006860-a3b8hyyr	4522	8	age	age	NN
cord-006860-a3b8hyyr	4522	9	21	21	CD
cord-006860-a3b8hyyr	4522	10	-	-	SYM
cord-006860-a3b8hyyr	4522	11	61	61	CD
cord-006860-a3b8hyyr	4522	12	ys	ys	NNP
cord-006860-a3b8hyyr	4522	13	median	median	JJ
cord-006860-a3b8hyyr	4522	14	39.8	39.8	CD
cord-006860-a3b8hyyr	4522	15	ys	ys	NNP
cord-006860-a3b8hyyr	4522	16	)	)	-RRB-
cord-006860-a3b8hyyr	4522	17	with	with	IN
cord-006860-a3b8hyyr	4522	18	venous	venous	JJ
cord-006860-a3b8hyyr	4522	19	thromtx	thromtx	NNP
cord-006860-a3b8hyyr	4522	20	~	~	NFP
cord-006860-a3b8hyyr	4522	21	emolism	emolism	NN
cord-006860-a3b8hyyr	4522	22	before	before	IN
cord-006860-a3b8hyyr	4522	23	the	the	DT
cord-006860-a3b8hyyr	4522	24	age	age	NN
cord-006860-a3b8hyyr	4522	25	of	of	IN
cord-006860-a3b8hyyr	4522	26	45	45	CD
cord-006860-a3b8hyyr	4522	27	years	year	NNS
cord-006860-a3b8hyyr	4522	28	were	be	VBD
cord-006860-a3b8hyyr	4522	29	investigated	investigate	VBN
cord-006860-a3b8hyyr	4522	30	in	in	IN
cord-006860-a3b8hyyr	4522	31	regard	regard	NN
cord-006860-a3b8hyyr	4522	32	to	to	IN
cord-006860-a3b8hyyr	4522	33	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4522	34	plasma	plasma	NN
cord-006860-a3b8hyyr	4522	35	fibrinolytie	fibrinolytie	NN
cord-006860-a3b8hyyr	4522	36	system	system	NN
cord-006860-a3b8hyyr	4522	37	.	.	.
cord-006860-a3b8hyyr	4523	1	In	in	IN
cord-006860-a3b8hyyr	4523	2	none	none	NN
cord-006860-a3b8hyyr	4523	3	of	of	IN
cord-006860-a3b8hyyr	4523	4	them	-PRON-	PRP
cord-006860-a3b8hyyr	4523	5	well	well	RB
cord-006860-a3b8hyyr	4523	6	established	establish	VBD
cord-006860-a3b8hyyr	4523	7	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	4523	8	risk	risk	NN
cord-006860-a3b8hyyr	4523	9	factors	factor	NNS
cord-006860-a3b8hyyr	4523	10	could	could	MD
cord-006860-a3b8hyyr	4523	11	be	be	VB
cord-006860-a3b8hyyr	4523	12	identified	identify	VBN
cord-006860-a3b8hyyr	4523	13	previously	previously	RB
cord-006860-a3b8hyyr	4523	14	.	.	.
cord-006860-a3b8hyyr	4524	1	Methods	method	NNS
cord-006860-a3b8hyyr	4524	2	:	:	:
cord-006860-a3b8hyyr	4524	3	Plasminogen	Plasminogen	NNP
cord-006860-a3b8hyyr	4524	4	~Behdngwerke	~behdngwerke	CD
cord-006860-a3b8hyyr	4524	5	)	)	-RRB-
cord-006860-a3b8hyyr	4524	6	,	,	,
cord-006860-a3b8hyyr	4524	7	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	4524	8	activity	activity	NN
cord-006860-a3b8hyyr	4524	9	(	(	-LRB-
cord-006860-a3b8hyyr	4524	10	ehromogenic	ehromogenic	NNP
cord-006860-a3b8hyyr	4524	11	assay	assay	NN
cord-006860-a3b8hyyr	4524	12	,	,	,
cord-006860-a3b8hyyr	4524	13	Biopool	Biopool	NNP
cord-006860-a3b8hyyr	4524	14	)	)	-RRB-
cord-006860-a3b8hyyr	4524	15	,	,	,
cord-006860-a3b8hyyr	4524	16	PAl	PAl	NNS
cord-006860-a3b8hyyr	4524	17	-	-	:
cord-006860-a3b8hyyr	4524	18	I	-PRON-	PRP
cord-006860-a3b8hyyr	4524	19	anugen	anugen	NNP
cord-006860-a3b8hyyr	4524	20	coneentration	coneentration	NNP
cord-006860-a3b8hyyr	4524	21	(	(	-LRB-
cord-006860-a3b8hyyr	4524	22	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	4524	23	,	,	,
cord-006860-a3b8hyyr	4524	24	Biopool	Biopool	NNP
cord-006860-a3b8hyyr	4524	25	)	)	-RRB-
cord-006860-a3b8hyyr	4524	26	,	,	,
cord-006860-a3b8hyyr	4524	27	t	t	NNP
cord-006860-a3b8hyyr	4524	28	-	-	HYPH
cord-006860-a3b8hyyr	4524	29	PA	PA	NNP
cord-006860-a3b8hyyr	4524	30	activity	activity	NN
cord-006860-a3b8hyyr	4524	31	(	(	-LRB-
cord-006860-a3b8hyyr	4524	32	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	4524	33	assay	assay	NN
cord-006860-a3b8hyyr	4524	34	,	,	,
cord-006860-a3b8hyyr	4524	35	Biopool	Biopool	NNP
cord-006860-a3b8hyyr	4524	36	)	)	-RRB-
cord-006860-a3b8hyyr	4524	37	and	and	CC
cord-006860-a3b8hyyr	4524	38	antigen	antigen	NN
cord-006860-a3b8hyyr	4524	39	concentration	concentration	NN
cord-006860-a3b8hyyr	4524	40	(	(	-LRB-
cord-006860-a3b8hyyr	4524	41	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	4524	42	,	,	,
cord-006860-a3b8hyyr	4524	43	Biopool	Biopool	NNP
cord-006860-a3b8hyyr	4524	44	)	)	-RRB-
cord-006860-a3b8hyyr	4524	45	were	be	VBD
cord-006860-a3b8hyyr	4524	46	measured	measure	VBN
cord-006860-a3b8hyyr	4524	47	before	before	RB
cord-006860-a3b8hyyr	4524	48	and	and	CC
cord-006860-a3b8hyyr	4524	49	after	after	IN
cord-006860-a3b8hyyr	4524	50	venous	venous	JJ
cord-006860-a3b8hyyr	4524	51	oeclusion	oeclusion	NN
cord-006860-a3b8hyyr	4524	52	.	.	.
cord-006860-a3b8hyyr	4525	1	VO	VO	NNP
cord-006860-a3b8hyyr	4525	2	was	be	VBD
cord-006860-a3b8hyyr	4525	3	performed	perform	VBN
cord-006860-a3b8hyyr	4525	4	z	z	NNP
cord-006860-a3b8hyyr	4525	5	12	12	CD
cord-006860-a3b8hyyr	4525	6	month	month	NN
cord-006860-a3b8hyyr	4525	7	after	after	IN
cord-006860-a3b8hyyr	4525	8	the	the	DT
cord-006860-a3b8hyyr	4525	9	last	last	JJ
cord-006860-a3b8hyyr	4525	10	thromboembolic	thromboembolic	NNP
cord-006860-a3b8hyyr	4525	11	epi	epi	NNP
cord-006860-a3b8hyyr	4525	12	~	~	NNP
cord-006860-a3b8hyyr	4525	13	xle	xle	NNP
cord-006860-a3b8hyyr	4525	14	.	.	.
cord-006860-a3b8hyyr	4526	1	24	24	CD
cord-006860-a3b8hyyr	4526	2	healthy	healthy	JJ
cord-006860-a3b8hyyr	4526	3	subjects	subject	NNS
cord-006860-a3b8hyyr	4526	4	(	(	-LRB-
cord-006860-a3b8hyyr	4526	5	median	median	JJ
cord-006860-a3b8hyyr	4526	6	age	age	NN
cord-006860-a3b8hyyr	4526	7	24.7	24.7	CD
cord-006860-a3b8hyyr	4526	8	ys	ys	NNP
cord-006860-a3b8hyyr	4526	9	)	)	-RRB-
cord-006860-a3b8hyyr	4526	10	served	serve	VBD
cord-006860-a3b8hyyr	4526	11	as	as	IN
cord-006860-a3b8hyyr	4526	12	controls	control	NNS
cord-006860-a3b8hyyr	4526	13	.	.	.
cord-006860-a3b8hyyr	4527	1	Results	result	NNS
cord-006860-a3b8hyyr	4527	2	.	.	.
cord-006860-a3b8hyyr	4527	3	"	"	''
cord-006860-a3b8hyyr	4528	1	24	24	CD
cord-006860-a3b8hyyr	4528	2	pts.(2.7	pts.(2.7	CD
cord-006860-a3b8hyyr	4528	3	%	%	NN
cord-006860-a3b8hyyr	4528	4	)	)	-RRB-
cord-006860-a3b8hyyr	4528	5	were	be	VBD
cord-006860-a3b8hyyr	4528	6	classified	classify	VBN
cord-006860-a3b8hyyr	4528	7	as	as	IN
cord-006860-a3b8hyyr	4528	8	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4528	9	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	4528	10	(	(	-LRB-
cord-006860-a3b8hyyr	4528	11	activity	activity	NN
cord-006860-a3b8hyyr	4528	12	and	and	CC
cord-006860-a3b8hyyr	4528	13	antigen	antigen	NN
cord-006860-a3b8hyyr	4528	14	)	)	-RRB-
cord-006860-a3b8hyyr	4528	15	.	.	.
cord-006860-a3b8hyyr	4529	1	142	142	CD
cord-006860-a3b8hyyr	4529	2	pts.(16	pts.(16	NNS
cord-006860-a3b8hyyr	4529	3	%	%	NN
cord-006860-a3b8hyyr	4529	4	)	)	-RRB-
cord-006860-a3b8hyyr	4529	5	had	have	VBD
cord-006860-a3b8hyyr	4529	6	significantly	significantly	RB
cord-006860-a3b8hyyr	4529	7	elevated	elevate	VBN
cord-006860-a3b8hyyr	4529	8	levels	level	NNS
cord-006860-a3b8hyyr	4529	9	of	of	IN
cord-006860-a3b8hyyr	4529	10	PAl	PAl	NNS
cord-006860-a3b8hyyr	4529	11	activity	activity	NN
cord-006860-a3b8hyyr	4529	12	(	(	-LRB-
cord-006860-a3b8hyyr	4529	13	up	up	IN
cord-006860-a3b8hyyr	4529	14	to	to	IN
cord-006860-a3b8hyyr	4529	15	120	120	CD
cord-006860-a3b8hyyr	4529	16	U	u	NN
cord-006860-a3b8hyyr	4529	17	/	/	SYM
cord-006860-a3b8hyyr	4529	18	ml	ml	NN
cord-006860-a3b8hyyr	4529	19	)	)	-RRB-
cord-006860-a3b8hyyr	4529	20	and	and	CC
cord-006860-a3b8hyyr	4529	21	PAl	PAl	NNP
cord-006860-a3b8hyyr	4529	22	antigen	antigen	NNP
cord-006860-a3b8hyyr	4529	23	(	(	-LRB-
cord-006860-a3b8hyyr	4529	24	up	up	IN
cord-006860-a3b8hyyr	4529	25	to	to	TO
cord-006860-a3b8hyyr	4529	26	90	90	CD
cord-006860-a3b8hyyr	4529	27	ng	ng	NN
cord-006860-a3b8hyyr	4529	28	/	/	SYM
cord-006860-a3b8hyyr	4529	29	ml	ml	NN
cord-006860-a3b8hyyr	4529	30	)	)	-RRB-
cord-006860-a3b8hyyr	4529	31	.	.	.
cord-006860-a3b8hyyr	4530	1	None	none	NN
cord-006860-a3b8hyyr	4530	2	of	of	IN
cord-006860-a3b8hyyr	4530	3	the	the	DT
cord-006860-a3b8hyyr	4530	4	pts	pts	NN
cord-006860-a3b8hyyr	4530	5	.	.	.
cord-006860-a3b8hyyr	4531	1	with	with	IN
cord-006860-a3b8hyyr	4531	2	high	high	JJ
cord-006860-a3b8hyyr	4531	3	PAl	PAl	NNS
cord-006860-a3b8hyyr	4531	4	levels	level	NNS
cord-006860-a3b8hyyr	4531	5	had	have	VBD
cord-006860-a3b8hyyr	4531	6	laboratory	laboratory	NN
cord-006860-a3b8hyyr	4531	7	signs	sign	NNS
cord-006860-a3b8hyyr	4531	8	of	of	IN
cord-006860-a3b8hyyr	4531	9	acute	acute	JJ
cord-006860-a3b8hyyr	4531	10	phase	phase	NN
cord-006860-a3b8hyyr	4531	11	reaction	reaction	NN
cord-006860-a3b8hyyr	4531	12	.	.	.
cord-006860-a3b8hyyr	4532	1	Low	low	JJ
cord-006860-a3b8hyyr	4532	2	t	t	NNP
cord-006860-a3b8hyyr	4532	3	-	-	HYPH
cord-006860-a3b8hyyr	4532	4	PA	PA	NNP
cord-006860-a3b8hyyr	4532	5	activity	activity	NN
cord-006860-a3b8hyyr	4532	6	could	could	MD
cord-006860-a3b8hyyr	4532	7	be	be	VB
cord-006860-a3b8hyyr	4532	8	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	4532	9	and	and	CC
cord-006860-a3b8hyyr	4532	10	confirmed	confirm	VBN
cord-006860-a3b8hyyr	4532	11	in	in	IN
cord-006860-a3b8hyyr	4532	12	121	121	CD
cord-006860-a3b8hyyr	4532	13	pts	pt	NNS
cord-006860-a3b8hyyr	4532	14	.	.	.
cord-006860-a3b8hyyr	4533	1	,	,	,
cord-006860-a3b8hyyr	4533	2	aecordingto	aecordingto	PDT
cord-006860-a3b8hyyr	4533	3	a	a	DT
cord-006860-a3b8hyyr	4533	4	prevalence	prevalence	NN
cord-006860-a3b8hyyr	4533	5	of	of	IN
cord-006860-a3b8hyyr	4533	6	13.6	13.6	CD
cord-006860-a3b8hyyr	4533	7	%	%	NN
cord-006860-a3b8hyyr	4533	8	(	(	-LRB-
cord-006860-a3b8hyyr	4533	9	range	range	NN
cord-006860-a3b8hyyr	4533	10	:	:	:
cord-006860-a3b8hyyr	4533	11	0	0	CD
cord-006860-a3b8hyyr	4533	12	-	-	SYM
cord-006860-a3b8hyyr	4533	13	2.7	2.7	CD
cord-006860-a3b8hyyr	4533	14	U	U	NNP
cord-006860-a3b8hyyr	4533	15	/	/	SYM
cord-006860-a3b8hyyr	4533	16	ml	ml	NN
cord-006860-a3b8hyyr	4533	17	;	;	:
cord-006860-a3b8hyyr	4533	18	reference	reference	NN
cord-006860-a3b8hyyr	4533	19	limils	limil	NNS
cord-006860-a3b8hyyr	4533	20	:	:	:
cord-006860-a3b8hyyr	4534	1	2.8	2.8	CD
cord-006860-a3b8hyyr	4534	2	-21.8	-21.8	CD
cord-006860-a3b8hyyr	4534	3	U	U	NNP
cord-006860-a3b8hyyr	4534	4	/	/	SYM
cord-006860-a3b8hyyr	4534	5	ml	ml	NN
cord-006860-a3b8hyyr	4534	6	)	)	-RRB-
cord-006860-a3b8hyyr	4534	7	.	.	.
cord-006860-a3b8hyyr	4535	1	However	however	RB
cord-006860-a3b8hyyr	4535	2	,	,	,
cord-006860-a3b8hyyr	4535	3	there	there	EX
cord-006860-a3b8hyyr	4535	4	was	be	VBD
cord-006860-a3b8hyyr	4535	5	a	a	DT
cord-006860-a3b8hyyr	4535	6	significant	significant	JJ
cord-006860-a3b8hyyr	4535	7	negative	negative	JJ
cord-006860-a3b8hyyr	4535	8	correlation	correlation	NN
cord-006860-a3b8hyyr	4535	9	between	between	IN
cord-006860-a3b8hyyr	4535	10	t	t	NNP
cord-006860-a3b8hyyr	4535	11	-	-	HYPH
cord-006860-a3b8hyyr	4535	12	PA	PA	NNP
cord-006860-a3b8hyyr	4535	13	activity	activity	NN
cord-006860-a3b8hyyr	4535	14	and	and	CC
cord-006860-a3b8hyyr	4535	15	PAl	PAl	NNS
cord-006860-a3b8hyyr	4535	16	values	value	NNS
cord-006860-a3b8hyyr	4535	17	.	.	.
cord-006860-a3b8hyyr	4536	1	In	in	IN
cord-006860-a3b8hyyr	4536	2	67	67	CD
cord-006860-a3b8hyyr	4536	3	pts	pt	NNS
cord-006860-a3b8hyyr	4536	4	.	.	.
cord-006860-a3b8hyyr	4537	1	(	(	-LRB-
cord-006860-a3b8hyyr	4537	2	55.4	55.4	CD
cord-006860-a3b8hyyr	4537	3	%	%	NN
cord-006860-a3b8hyyr	4537	4	)	)	-RRB-
cord-006860-a3b8hyyr	4538	1	the	the	DT
cord-006860-a3b8hyyr	4538	2	low	low	JJ
cord-006860-a3b8hyyr	4538	3	t	t	NNP
cord-006860-a3b8hyyr	4538	4	-	-	HYPH
cord-006860-a3b8hyyr	4538	5	PA	PA	NNP
cord-006860-a3b8hyyr	4538	6	activity	activity	NN
cord-006860-a3b8hyyr	4538	7	was	be	VBD
cord-006860-a3b8hyyr	4538	8	associated	associate	VBN
cord-006860-a3b8hyyr	4538	9	with	with	IN
cord-006860-a3b8hyyr	4538	10	increased	increase	VBN
cord-006860-a3b8hyyr	4538	11	PAl	PAl	NNS
cord-006860-a3b8hyyr	4538	12	levels	level	NNS
cord-006860-a3b8hyyr	4538	13	whereas	whereas	IN
cord-006860-a3b8hyyr	4538	14	the	the	DT
cord-006860-a3b8hyyr	4538	15	t	t	NNP
cord-006860-a3b8hyyr	4538	16	-	-	HYPH
cord-006860-a3b8hyyr	4538	17	PA	PA	NNP
cord-006860-a3b8hyyr	4538	18	antigen	antigen	NN
cord-006860-a3b8hyyr	4538	19	concentration	concentration	NN
cord-006860-a3b8hyyr	4538	20	was	be	VBD
cord-006860-a3b8hyyr	4538	21	normal	normal	JJ
cord-006860-a3b8hyyr	4538	22	.	.	.
cord-006860-a3b8hyyr	4539	1	A	a	DT
cord-006860-a3b8hyyr	4539	2	parallel	parallel	JJ
cord-006860-a3b8hyyr	4539	3	reduction	reduction	NN
cord-006860-a3b8hyyr	4539	4	of	of	IN
cord-006860-a3b8hyyr	4539	5	t	t	NNP
cord-006860-a3b8hyyr	4539	6	-	-	HYPH
cord-006860-a3b8hyyr	4539	7	PA	PA	NNP
cord-006860-a3b8hyyr	4539	8	activity	activity	NN
cord-006860-a3b8hyyr	4539	9	and	and	CC
cord-006860-a3b8hyyr	4539	10	t	t	NNP
cord-006860-a3b8hyyr	4539	11	-	-	HYPH
cord-006860-a3b8hyyr	4539	12	PA	PA	NNP
cord-006860-a3b8hyyr	4539	13	antigen	antigen	NN
cord-006860-a3b8hyyr	4539	14	(	(	-LRB-
cord-006860-a3b8hyyr	4539	15	range	range	NN
cord-006860-a3b8hyyr	4539	16	:	:	:
cord-006860-a3b8hyyr	4539	17	0.35	0.35	CD
cord-006860-a3b8hyyr	4539	18	-	-	SYM
cord-006860-a3b8hyyr	4539	19	3.5	3.5	CD
cord-006860-a3b8hyyr	4539	20	ng	ng	NN
cord-006860-a3b8hyyr	4539	21	/	/	SYM
cord-006860-a3b8hyyr	4539	22	ml	ml	NN
cord-006860-a3b8hyyr	4539	23	;	;	:
cord-006860-a3b8hyyr	4539	24	reference	reference	NN
cord-006860-a3b8hyyr	4539	25	limits	limit	NNS
cord-006860-a3b8hyyr	4539	26	:	:	:
cord-006860-a3b8hyyr	4539	27	3.6	3.6	CD
cord-006860-a3b8hyyr	4539	28	-21.0	-21.0	CD
cord-006860-a3b8hyyr	4539	29	ng	ng	NN
cord-006860-a3b8hyyr	4539	30	/	/	SYM
cord-006860-a3b8hyyr	4539	31	ml	ml	NN
cord-006860-a3b8hyyr	4539	32	)	)	-RRB-
cord-006860-a3b8hyyr	4539	33	were	be	VBD
cord-006860-a3b8hyyr	4539	34	determined	determine	VBN
cord-006860-a3b8hyyr	4539	35	repeatedly	repeatedly	RB
cord-006860-a3b8hyyr	4539	36	in	in	IN
cord-006860-a3b8hyyr	4539	37	54	54	CD
cord-006860-a3b8hyyr	4539	38	pts	pt	NNS
cord-006860-a3b8hyyr	4539	39	.	.	.
cord-006860-a3b8hyyr	4540	1	(	(	-LRB-
cord-006860-a3b8hyyr	4540	2	F	F	NNP
cord-006860-a3b8hyyr	4540	3	23	23	CD
cord-006860-a3b8hyyr	4540	4	,	,	,
cord-006860-a3b8hyyr	4540	5	M	M	NNP
cord-006860-a3b8hyyr	4540	6	31	31	CD
cord-006860-a3b8hyyr	4540	7	,	,	,
cord-006860-a3b8hyyr	4540	8	median	median	NN
cord-006860-a3b8hyyr	4540	9	age	age	NN
cord-006860-a3b8hyyr	4540	10	39	39	CD
cord-006860-a3b8hyyr	4540	11	ys	ys	NN
cord-006860-a3b8hyyr	4540	12	)	)	-RRB-
cord-006860-a3b8hyyr	4540	13	.	.	.
cord-006860-a3b8hyyr	4541	1	Thus	thus	RB
cord-006860-a3b8hyyr	4541	2	,	,	,
cord-006860-a3b8hyyr	4541	3	the	the	DT
cord-006860-a3b8hyyr	4541	4	prevalence	prevalence	NN
cord-006860-a3b8hyyr	4541	5	of	of	IN
cord-006860-a3b8hyyr	4541	6	a	a	DT
cord-006860-a3b8hyyr	4541	7	defective	defective	JJ
cord-006860-a3b8hyyr	4541	8	t	t	NNP
cord-006860-a3b8hyyr	4541	9	-	-	HYPH
cord-006860-a3b8hyyr	4541	10	PA	PA	NNP
cord-006860-a3b8hyyr	4541	11	release	release	NN
cord-006860-a3b8hyyr	4541	12	was	be	VBD
cord-006860-a3b8hyyr	4541	13	6.1	6.1	CD
cord-006860-a3b8hyyr	4541	14	%	%	NN
cord-006860-a3b8hyyr	4541	15	in	in	IN
cord-006860-a3b8hyyr	4541	16	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4541	17	study	study	NN
cord-006860-a3b8hyyr	4541	18	group	group	NN
cord-006860-a3b8hyyr	4541	19	.	.	.
cord-006860-a3b8hyyr	4542	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	4542	2	.	.	.
cord-006860-a3b8hyyr	4542	3	"	"	''
cord-006860-a3b8hyyr	4543	1	In	in	IN
cord-006860-a3b8hyyr	4543	2	comparison	comparison	NN
cord-006860-a3b8hyyr	4543	3	to	to	IN
cord-006860-a3b8hyyr	4543	4	the	the	DT
cord-006860-a3b8hyyr	4543	5	frequency	frequency	NN
cord-006860-a3b8hyyr	4543	6	of	of	IN
cord-006860-a3b8hyyr	4543	7	inherited	inherit	VBN
cord-006860-a3b8hyyr	4543	8	deficiencies	deficiency	NNS
cord-006860-a3b8hyyr	4543	9	of	of	IN
cord-006860-a3b8hyyr	4543	10	other	other	JJ
cord-006860-a3b8hyyr	4543	11	well	well	RB
cord-006860-a3b8hyyr	4543	12	established	establish	VBN
cord-006860-a3b8hyyr	4543	13	thrombophila	thrombophila	NN
cord-006860-a3b8hyyr	4543	14	risk	risk	NN
cord-006860-a3b8hyyr	4543	15	factors	factor	NNS
cord-006860-a3b8hyyr	4543	16	we	-PRON-	PRP
cord-006860-a3b8hyyr	4543	17	have	have	VBP
cord-006860-a3b8hyyr	4543	18	observed	observe	VBN
cord-006860-a3b8hyyr	4543	19	a	a	DT
cord-006860-a3b8hyyr	4543	20	relativel~	relativel~	JJ
cord-006860-a3b8hyyr	4543	21	high	high	JJ
cord-006860-a3b8hyyr	4543	22	prevalence	prevalence	NN
cord-006860-a3b8hyyr	4543	23	of	of	IN
cord-006860-a3b8hyyr	4543	24	diminished	diminished	JJ
cord-006860-a3b8hyyr	4543	25	t	t	NNP
cord-006860-a3b8hyyr	4543	26	-	-	HYPH
cord-006860-a3b8hyyr	4543	27	PA	PA	NNP
cord-006860-a3b8hyyr	4543	28	activity	activity	NN
cord-006860-a3b8hyyr	4543	29	,	,	,
cord-006860-a3b8hyyr	4543	30	elevation	elevation	NN
cord-006860-a3b8hyyr	4543	31	of	of	IN
cord-006860-a3b8hyyr	4543	32	PAl	PAl	NNS
cord-006860-a3b8hyyr	4543	33	respectively	respectively	RB
cord-006860-a3b8hyyr	4543	34	in	in	IN
cord-006860-a3b8hyyr	4543	35	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4543	36	study	study	NN
cord-006860-a3b8hyyr	4543	37	group	group	NN
cord-006860-a3b8hyyr	4543	38	.	.	.
cord-006860-a3b8hyyr	4544	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	4544	2	data	datum	NNS
cord-006860-a3b8hyyr	4544	3	strongly	strongly	RB
cord-006860-a3b8hyyr	4544	4	indicate	indicate	VBP
cord-006860-a3b8hyyr	4544	5	that	that	IN
cord-006860-a3b8hyyr	4544	6	besides	besides	IN
cord-006860-a3b8hyyr	4544	7	t	t	NNP
cord-006860-a3b8hyyr	4544	8	-	-	HYPH
cord-006860-a3b8hyyr	4544	9	PA	PA	NNP
cord-006860-a3b8hyyr	4544	10	and	and	CC
cord-006860-a3b8hyyr	4544	11	PAl	PAl	NNS
cord-006860-a3b8hyyr	4544	12	acuvity	acuvity	NN
cord-006860-a3b8hyyr	4544	13	,	,	,
cord-006860-a3b8hyyr	4544	14	antigen	antigen	NN
cord-006860-a3b8hyyr	4544	15	concentration	concentration	NN
cord-006860-a3b8hyyr	4544	16	for	for	IN
cord-006860-a3b8hyyr	4544	17	both	both	DT
cord-006860-a3b8hyyr	4544	18	parameters	parameter	NNS
cord-006860-a3b8hyyr	4544	19	should	should	MD
cord-006860-a3b8hyyr	4544	20	be	be	VB
cord-006860-a3b8hyyr	4544	21	determined	determine	VBN
cord-006860-a3b8hyyr	4544	22	in	in	IN
cord-006860-a3b8hyyr	4544	23	pts	pts	NN
cord-006860-a3b8hyyr	4544	24	.	.	.
cord-006860-a3b8hyyr	4545	1	with	with	IN
cord-006860-a3b8hyyr	4545	2	thrombophilia	thrombophilia	NNP
cord-006860-a3b8hyyr	4545	3	.	.	.
cord-006860-a3b8hyyr	4546	1	The	the	DT
cord-006860-a3b8hyyr	4546	2	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	4546	3	and	and	CC
cord-006860-a3b8hyyr	4546	4	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	4546	5	effect	effect	NN
cord-006860-a3b8hyyr	4546	6	of	of	IN
cord-006860-a3b8hyyr	4546	7	the	the	DT
cord-006860-a3b8hyyr	4546	8	supersulfated	supersulfated	JJ
cord-006860-a3b8hyyr	4546	9	low	low	JJ
cord-006860-a3b8hyyr	4546	10	molecular	molecular	JJ
cord-006860-a3b8hyyr	4546	11	weight	weight	NN
cord-006860-a3b8hyyr	4546	12	heparin	heparin	NN
cord-006860-a3b8hyyr	4546	13	SSH	SSH	NNP
cord-006860-a3b8hyyr	4546	14	14	14	CD
cord-006860-a3b8hyyr	4546	15	was	be	VBD
cord-006860-a3b8hyyr	4546	16	studied	study	VBN
cord-006860-a3b8hyyr	4546	17	after	after	IN
cord-006860-a3b8hyyr	4546	18	i.v	i.v	NNP
cord-006860-a3b8hyyr	4546	19	.	.	NNP
cord-006860-a3b8hyyr	4546	20	and	and	CC
cord-006860-a3b8hyyr	4546	21	s.c	s.c	NNP
cord-006860-a3b8hyyr	4546	22	.	.	NNP
cord-006860-a3b8hyyr	4546	23	administration	administration	NN
cord-006860-a3b8hyyr	4546	24	in	in	IN
cord-006860-a3b8hyyr	4546	25	rats	rat	NNS
cord-006860-a3b8hyyr	4546	26	.	.	.
cord-006860-a3b8hyyr	4547	1	Thrombus	Thrombus	NNP
cord-006860-a3b8hyyr	4547	2	formation	formation	NN
cord-006860-a3b8hyyr	4547	3	in	in	IN
cord-006860-a3b8hyyr	4547	4	the	the	DT
cord-006860-a3b8hyyr	4547	5	jugular	jugular	NN
cord-006860-a3b8hyyr	4547	6	vein	vein	NN
cord-006860-a3b8hyyr	4547	7	was	be	VBD
cord-006860-a3b8hyyr	4547	8	induced	induce	VBN
cord-006860-a3b8hyyr	4547	9	by	by	IN
cord-006860-a3b8hyyr	4547	10	i.v	i.v	NNP
cord-006860-a3b8hyyr	4547	11	.	.	NNP
cord-006860-a3b8hyyr	4547	12	injection	injection	NN
cord-006860-a3b8hyyr	4547	13	of	of	IN
cord-006860-a3b8hyyr	4547	14	activated	activate	VBN
cord-006860-a3b8hyyr	4547	15	human	human	JJ
cord-006860-a3b8hyyr	4547	16	serum	serum	NN
cord-006860-a3b8hyyr	4547	17	and	and	CC
cord-006860-a3b8hyyr	4547	18	following	follow	VBG
cord-006860-a3b8hyyr	4547	19	stasis	stasis	NN
cord-006860-a3b8hyyr	4547	20	for	for	IN
cord-006860-a3b8hyyr	4547	21	20	20	CD
cord-006860-a3b8hyyr	4547	22	rain	rain	NN
cord-006860-a3b8hyyr	4547	23	and	and	CC
cord-006860-a3b8hyyr	4547	24	was	be	VBD
cord-006860-a3b8hyyr	4547	25	assessed	assess	VBN
cord-006860-a3b8hyyr	4547	26	by	by	IN
cord-006860-a3b8hyyr	4547	27	a	a	DT
cord-006860-a3b8hyyr	4547	28	thrombus	thrombus	NN
cord-006860-a3b8hyyr	4547	29	score	score	NN
cord-006860-a3b8hyyr	4547	30	ranging	range	VBG
cord-006860-a3b8hyyr	4547	31	from	from	IN
cord-006860-a3b8hyyr	4547	32	0	0	NFP
cord-006860-a3b8hyyr	4547	33	(	(	-LRB-
cord-006860-a3b8hyyr	4547	34	no	no	DT
cord-006860-a3b8hyyr	4547	35	thrombus	thrombus	NN
cord-006860-a3b8hyyr	4547	36	formation	formation	NN
cord-006860-a3b8hyyr	4547	37	)	)	-RRB-
cord-006860-a3b8hyyr	4547	38	until	until	IN
cord-006860-a3b8hyyr	4547	39	3	3	LS
cord-006860-a3b8hyyr	4547	40	(	(	-LRB-
cord-006860-a3b8hyyr	4547	41	complete	complete	JJ
cord-006860-a3b8hyyr	4547	42	thrombus	thrombus	NN
cord-006860-a3b8hyyr	4547	43	formation	formation	NN
cord-006860-a3b8hyyr	4547	44	)	)	-RRB-
cord-006860-a3b8hyyr	4547	45	.	.	.
cord-006860-a3b8hyyr	4548	1	SSH	SSH	NNP
cord-006860-a3b8hyyr	4548	2	t4	t4	NNP
cord-006860-a3b8hyyr	4548	3	injected	inject	VBD
cord-006860-a3b8hyyr	4548	4	either	either	CC
cord-006860-a3b8hyyr	4548	5	10	10	CD
cord-006860-a3b8hyyr	4548	6	min	min	NN
cord-006860-a3b8hyyr	4548	7	(	(	-LRB-
cord-006860-a3b8hyyr	4548	8	i.v	i.v	NNP
cord-006860-a3b8hyyr	4548	9	.	.	NNP
cord-006860-a3b8hyyr	4548	10	)	)	-RRB-
cord-006860-a3b8hyyr	4548	11	or	or	CC
cord-006860-a3b8hyyr	4548	12	30	30	CD
cord-006860-a3b8hyyr	4548	13	rain	rain	NN
cord-006860-a3b8hyyr	4548	14	(	(	-LRB-
cord-006860-a3b8hyyr	4548	15	s.c	s.c	NNP
cord-006860-a3b8hyyr	4548	16	.	.	NNP
cord-006860-a3b8hyyr	4548	17	)	)	-RRB-
cord-006860-a3b8hyyr	4549	1	before	before	IN
cord-006860-a3b8hyyr	4549	2	thrombus	thrombus	NN
cord-006860-a3b8hyyr	4549	3	induction	induction	NN
cord-006860-a3b8hyyr	4549	4	caused	cause	VBD
cord-006860-a3b8hyyr	4549	5	a	a	DT
cord-006860-a3b8hyyr	4549	6	dose	dose	NN
cord-006860-a3b8hyyr	4549	7	-	-	HYPH
cord-006860-a3b8hyyr	4549	8	dependent	dependent	JJ
cord-006860-a3b8hyyr	4549	9	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	4549	10	effect	effect	NN
cord-006860-a3b8hyyr	4549	11	in	in	IN
cord-006860-a3b8hyyr	4549	12	a	a	DT
cord-006860-a3b8hyyr	4549	13	range	range	NN
cord-006860-a3b8hyyr	4549	14	from	from	IN
cord-006860-a3b8hyyr	4549	15	0.25	0.25	CD
cord-006860-a3b8hyyr	4549	16	to	to	IN
cord-006860-a3b8hyyr	4549	17	2	2	CD
cord-006860-a3b8hyyr	4549	18	mg	mg	NNP
cord-006860-a3b8hyyr	4549	19	/	/	SYM
cord-006860-a3b8hyyr	4549	20	kg	kg	NNP
cord-006860-a3b8hyyr	4549	21	i.v	i.v	NNP
cord-006860-a3b8hyyr	4549	22	.	.	NNP
cord-006860-a3b8hyyr	4549	23	and	and	CC
cord-006860-a3b8hyyr	4549	24	1	1	CD
cord-006860-a3b8hyyr	4549	25	to	to	IN
cord-006860-a3b8hyyr	4549	26	4	4	CD
cord-006860-a3b8hyyr	4549	27	mg	mg	NNP
cord-006860-a3b8hyyr	4549	28	/	/	SYM
cord-006860-a3b8hyyr	4549	29	kg	kg	NNP
cord-006860-a3b8hyyr	4549	30	s.c	s.c	NNP
cord-006860-a3b8hyyr	4549	31	.	.	.
cord-006860-a3b8hyyr	4550	1	There	there	EX
cord-006860-a3b8hyyr	4550	2	were	be	VBD
cord-006860-a3b8hyyr	4550	3	clear	clear	JJ
cord-006860-a3b8hyyr	4550	4	differences	difference	NNS
cord-006860-a3b8hyyr	4550	5	in	in	IN
cord-006860-a3b8hyyr	4550	6	the	the	DT
cord-006860-a3b8hyyr	4550	7	antithromboric	antithromboric	JJ
cord-006860-a3b8hyyr	4550	8	effectiveness	effectiveness	NN
cord-006860-a3b8hyyr	4550	9	between	between	IN
cord-006860-a3b8hyyr	4550	10	female	female	JJ
cord-006860-a3b8hyyr	4550	11	and	and	CC
cord-006860-a3b8hyyr	4550	12	male	male	JJ
cord-006860-a3b8hyyr	4550	13	animals	animal	NNS
cord-006860-a3b8hyyr	4550	14	,	,	,
cord-006860-a3b8hyyr	4550	15	i.e	i.e	XX
cord-006860-a3b8hyyr	4550	16	,	,	,
cord-006860-a3b8hyyr	4550	17	in	in	IN
cord-006860-a3b8hyyr	4550	18	female	female	JJ
cord-006860-a3b8hyyr	4550	19	rats	rat	NNS
cord-006860-a3b8hyyr	4550	20	antithrombotically	antithrombotically	RB
cord-006860-a3b8hyyr	4550	21	effective	effective	JJ
cord-006860-a3b8hyyr	4550	22	doses	dose	NNS
cord-006860-a3b8hyyr	4550	23	were	be	VBD
cord-006860-a3b8hyyr	4550	24	lower	low	JJR
cord-006860-a3b8hyyr	4550	25	than	than	IN
cord-006860-a3b8hyyr	4550	26	in	in	IN
cord-006860-a3b8hyyr	4550	27	male	male	JJ
cord-006860-a3b8hyyr	4550	28	rats	rat	NNS
cord-006860-a3b8hyyr	4550	29	(	(	-LRB-
cord-006860-a3b8hyyr	4550	30	EDh0	EDh0	VBN
cord-006860-a3b8hyyr	4550	31	after	after	IN
cord-006860-a3b8hyyr	4550	32	i.v	i.v	NNP
cord-006860-a3b8hyyr	4550	33	.	.	.
cord-006860-a3b8hyyr	4550	34	injection	injection	NN
cord-006860-a3b8hyyr	4550	35	in	in	IN
cord-006860-a3b8hyyr	4550	36	females	female	NNS
cord-006860-a3b8hyyr	4550	37	0.35	0.35	CD
cord-006860-a3b8hyyr	4550	38	mg	mg	NNP
cord-006860-a3b8hyyr	4550	39	/	/	SYM
cord-006860-a3b8hyyr	4550	40	kg	kg	NNP
cord-006860-a3b8hyyr	4550	41	,	,	,
cord-006860-a3b8hyyr	4550	42	in	in	IN
cord-006860-a3b8hyyr	4550	43	males	male	NNS
cord-006860-a3b8hyyr	4550	44	0.9	0.9	CD
cord-006860-a3b8hyyr	4550	45	mg	mg	NNP
cord-006860-a3b8hyyr	4550	46	/	/	SYM
cord-006860-a3b8hyyr	4550	47	kg	kg	NNP
cord-006860-a3b8hyyr	4550	48	)	)	-RRB-
cord-006860-a3b8hyyr	4550	49	.	.	.
cord-006860-a3b8hyyr	4551	1	The	the	DT
cord-006860-a3b8hyyr	4551	2	sex	sex	NN
cord-006860-a3b8hyyr	4551	3	differences	difference	NNS
cord-006860-a3b8hyyr	4551	4	were	be	VBD
cord-006860-a3b8hyyr	4551	5	confirmed	confirm	VBN
cord-006860-a3b8hyyr	4551	6	in	in	IN
cord-006860-a3b8hyyr	4551	7	studies	study	NNS
cord-006860-a3b8hyyr	4551	8	on	on	IN
cord-006860-a3b8hyyr	4551	9	the	the	DT
cord-006860-a3b8hyyr	4551	10	time	time	NN
cord-006860-a3b8hyyr	4551	11	course	course	NN
cord-006860-a3b8hyyr	4551	12	of	of	IN
cord-006860-a3b8hyyr	4551	13	the	the	DT
cord-006860-a3b8hyyr	4551	14	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	4551	15	effect	effect	NN
cord-006860-a3b8hyyr	4551	16	.	.	.
cord-006860-a3b8hyyr	4552	1	After	after	IN
cord-006860-a3b8hyyr	4552	2	i.v	i.v	NNP
cord-006860-a3b8hyyr	4552	3	.	.	.
cord-006860-a3b8hyyr	4552	4	injection	injection	NN
cord-006860-a3b8hyyr	4552	5	of	of	IN
cord-006860-a3b8hyyr	4552	6	fully	fully	RB
cord-006860-a3b8hyyr	4552	7	effective	effective	JJ
cord-006860-a3b8hyyr	4552	8	doses	dose	NNS
cord-006860-a3b8hyyr	4552	9	(	(	-LRB-
cord-006860-a3b8hyyr	4552	10	2	2	CD
cord-006860-a3b8hyyr	4552	11	mg	mg	NNP
cord-006860-a3b8hyyr	4552	12	/	/	SYM
cord-006860-a3b8hyyr	4552	13	kg	kg	NNP
cord-006860-a3b8hyyr	4552	14	i.v	i.v	NNP
cord-006860-a3b8hyyr	4552	15	.	.	.
cord-006860-a3b8hyyr	4553	1	and	and	CC
cord-006860-a3b8hyyr	4553	2	4	4	CD
cord-006860-a3b8hyyr	4553	3	mg	mg	NNP
cord-006860-a3b8hyyr	4553	4	/	/	SYM
cord-006860-a3b8hyyr	4553	5	kg	kg	NNP
cord-006860-a3b8hyyr	4553	6	s.c	s.c	NNP
cord-006860-a3b8hyyr	4553	7	.	.	.
cord-006860-a3b8hyyr	4554	1	,	,	,
cord-006860-a3b8hyyr	4554	2	resp	resp	NNP
cord-006860-a3b8hyyr	4554	3	.	.	.
cord-006860-a3b8hyyr	4554	4	)	)	-RRB-
cord-006860-a3b8hyyr	4555	1	the	the	DT
cord-006860-a3b8hyyr	4555	2	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	4555	3	effect	effect	NN
cord-006860-a3b8hyyr	4555	4	disappeared	disappear	VBD
cord-006860-a3b8hyyr	4555	5	after	after	IN
cord-006860-a3b8hyyr	4555	6	8	8	CD
cord-006860-a3b8hyyr	4555	7	h	h	NN
cord-006860-a3b8hyyr	4555	8	in	in	IN
cord-006860-a3b8hyyr	4555	9	female	female	NN
cord-006860-a3b8hyyr	4555	10	or	or	CC
cord-006860-a3b8hyyr	4555	11	after	after	IN
cord-006860-a3b8hyyr	4555	12	4	4	CD
cord-006860-a3b8hyyr	4555	13	h	h	NN
cord-006860-a3b8hyyr	4555	14	in	in	IN
cord-006860-a3b8hyyr	4555	15	male	male	JJ
cord-006860-a3b8hyyr	4555	16	rats	rat	NNS
cord-006860-a3b8hyyr	4555	17	.	.	.
cord-006860-a3b8hyyr	4556	1	For	for	IN
cord-006860-a3b8hyyr	4556	2	studies	study	NNS
cord-006860-a3b8hyyr	4556	3	on	on	IN
cord-006860-a3b8hyyr	4556	4	the	the	DT
cord-006860-a3b8hyyr	4556	5	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	4556	6	action	action	NN
cord-006860-a3b8hyyr	4556	7	blood	blood	NN
cord-006860-a3b8hyyr	4556	8	was	be	VBD
cord-006860-a3b8hyyr	4556	9	drawn	draw	VBN
cord-006860-a3b8hyyr	4556	10	from	from	IN
cord-006860-a3b8hyyr	4556	11	the	the	DT
cord-006860-a3b8hyyr	4556	12	femoral	femoral	JJ
cord-006860-a3b8hyyr	4556	13	artery	artery	NN
cord-006860-a3b8hyyr	4556	14	and	and	CC
cord-006860-a3b8hyyr	4556	15	after	after	IN
cord-006860-a3b8hyyr	4556	16	centrifugation	centrifugation	VBG
cord-006860-a3b8hyyr	4556	17	global	global	JJ
cord-006860-a3b8hyyr	4556	18	clotting	clotting	NN
cord-006860-a3b8hyyr	4556	19	assays	assay	NNS
cord-006860-a3b8hyyr	4556	20	were	be	VBD
cord-006860-a3b8hyyr	4556	21	performed	perform	VBN
cord-006860-a3b8hyyr	4556	22	in	in	IN
cord-006860-a3b8hyyr	4556	23	plasma	plasma	NN
cord-006860-a3b8hyyr	4556	24	.	.	.
cord-006860-a3b8hyyr	4557	1	Similar	similar	JJ
cord-006860-a3b8hyyr	4557	2	to	to	IN
cord-006860-a3b8hyyr	4557	3	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4557	4	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	4557	5	action	action	NN
cord-006860-a3b8hyyr	4557	6	SSH	ssh	NN
cord-006860-a3b8hyyr	4557	7	14	14	CD
cord-006860-a3b8hyyr	4557	8	also	also	RB
cord-006860-a3b8hyyr	4557	9	caused	cause	VBD
cord-006860-a3b8hyyr	4557	10	doseand	doseand	NN
cord-006860-a3b8hyyr	4557	11	sex	sex	NN
cord-006860-a3b8hyyr	4557	12	-	-	HYPH
cord-006860-a3b8hyyr	4557	13	dependent	dependent	JJ
cord-006860-a3b8hyyr	4557	14	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	4557	15	effects	effect	NNS
cord-006860-a3b8hyyr	4557	16	.	.	.
cord-006860-a3b8hyyr	4558	1	The	the	DT
cord-006860-a3b8hyyr	4558	2	most	most	RBS
cord-006860-a3b8hyyr	4558	3	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	4558	4	assays	assay	NNS
cord-006860-a3b8hyyr	4558	5	were	be	VBD
cord-006860-a3b8hyyr	4558	6	the	the	DT
cord-006860-a3b8hyyr	4558	7	APTT	APTT	NNP
cord-006860-a3b8hyyr	4558	8	and	and	CC
cord-006860-a3b8hyyr	4558	9	the	the	DT
cord-006860-a3b8hyyr	4558	10	heptest	heptest	NN
cord-006860-a3b8hyyr	4558	11	;	;	,
cord-006860-a3b8hyyr	4558	12	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	4558	13	time	time	NN
cord-006860-a3b8hyyr	4558	14	and	and	CC
cord-006860-a3b8hyyr	4558	15	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4558	16	time	time	NN
cord-006860-a3b8hyyr	4558	17	were	be	VBD
cord-006860-a3b8hyyr	4558	18	less	less	RBR
cord-006860-a3b8hyyr	4558	19	or	or	CC
cord-006860-a3b8hyyr	4558	20	not	not	RB
cord-006860-a3b8hyyr	4558	21	influenced	influence	VBN
cord-006860-a3b8hyyr	4558	22	by	by	IN
cord-006860-a3b8hyyr	4558	23	SSH	SSH	NNP
cord-006860-a3b8hyyr	4558	24	14	14	CD
cord-006860-a3b8hyyr	4558	25	.	.	.
cord-006860-a3b8hyyr	4559	1	In	in	IN
cord-006860-a3b8hyyr	4559	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	4559	3	,	,	,
cord-006860-a3b8hyyr	4559	4	SSH	SSH	NNP
cord-006860-a3b8hyyr	4559	5	14	14	CD
cord-006860-a3b8hyyr	4559	6	was	be	VBD
cord-006860-a3b8hyyr	4559	7	found	find	VBN
cord-006860-a3b8hyyr	4559	8	to	to	TO
cord-006860-a3b8hyyr	4559	9	be	be	VB
cord-006860-a3b8hyyr	4559	10	an	an	DT
cord-006860-a3b8hyyr	4559	11	effective	effective	JJ
cord-006860-a3b8hyyr	4559	12	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	4559	13	and	and	CC
cord-006860-a3b8hyyr	4559	14	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	4559	15	agent	agent	NN
cord-006860-a3b8hyyr	4559	16	in	in	IN
cord-006860-a3b8hyyr	4559	17	experimental	experimental	JJ
cord-006860-a3b8hyyr	4559	18	studies	study	NNS
cord-006860-a3b8hyyr	4559	19	in	in	IN
cord-006860-a3b8hyyr	4559	20	rats	rat	NNS
cord-006860-a3b8hyyr	4559	21	.	.	.
cord-006860-a3b8hyyr	4560	1	At	at	IN
cord-006860-a3b8hyyr	4560	2	present	present	NN
cord-006860-a3b8hyyr	4560	3	there	there	EX
cord-006860-a3b8hyyr	4560	4	is	be	VBZ
cord-006860-a3b8hyyr	4560	5	no	no	DT
cord-006860-a3b8hyyr	4560	6	explanation	explanation	NN
cord-006860-a3b8hyyr	4560	7	for	for	IN
cord-006860-a3b8hyyr	4560	8	the	the	DT
cord-006860-a3b8hyyr	4560	9	clear	clear	JJ
cord-006860-a3b8hyyr	4560	10	sex	sex	NN
cord-006860-a3b8hyyr	4560	11	differences	difference	NNS
cord-006860-a3b8hyyr	4560	12	found	find	VBN
cord-006860-a3b8hyyr	4560	13	in	in	IN
cord-006860-a3b8hyyr	4560	14	this	this	DT
cord-006860-a3b8hyyr	4560	15	species	specie	NNS
cord-006860-a3b8hyyr	4560	16	.	.	.
cord-006860-a3b8hyyr	4561	1	Venous	venous	JJ
cord-006860-a3b8hyyr	4561	2	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	4561	3	disease	disease	NN
cord-006860-a3b8hyyr	4561	4	is	be	VBZ
cord-006860-a3b8hyyr	4561	5	the	the	DT
cord-006860-a3b8hyyr	4561	6	most	most	RBS
cord-006860-a3b8hyyr	4561	7	frequent	frequent	JJ
cord-006860-a3b8hyyr	4561	8	complication	complication	NN
cord-006860-a3b8hyyr	4561	9	in	in	IN
cord-006860-a3b8hyyr	4561	10	patients	patient	NNS
cord-006860-a3b8hyyr	4561	11	undergoing	undergo	VBG
cord-006860-a3b8hyyr	4561	12	total	total	JJ
cord-006860-a3b8hyyr	4561	13	knee	knee	NN
cord-006860-a3b8hyyr	4561	14	replacement	replacement	NN
cord-006860-a3b8hyyr	4561	15	therapy	therapy	NN
cord-006860-a3b8hyyr	4561	16	.	.	.
cord-006860-a3b8hyyr	4562	1	Patients	patient	NNS
cord-006860-a3b8hyyr	4562	2	and	and	CC
cord-006860-a3b8hyyr	4562	3	methods	method	NNS
cord-006860-a3b8hyyr	4562	4	:	:	:
cord-006860-a3b8hyyr	4562	5	After	after	IN
cord-006860-a3b8hyyr	4562	6	informed	informed	JJ
cord-006860-a3b8hyyr	4562	7	consent	consent	NN
cord-006860-a3b8hyyr	4562	8	3x30	3x30	CD
cord-006860-a3b8hyyr	4562	9	patients	patient	NNS
cord-006860-a3b8hyyr	4562	10	were	be	VBD
cord-006860-a3b8hyyr	4562	11	included	include	VBN
cord-006860-a3b8hyyr	4562	12	in	in	IN
cord-006860-a3b8hyyr	4562	13	an	an	DT
cord-006860-a3b8hyyr	4562	14	open	open	JJ
cord-006860-a3b8hyyr	4562	15	randomized	randomized	JJ
cord-006860-a3b8hyyr	4562	16	clinical	clinical	JJ
cord-006860-a3b8hyyr	4562	17	study	study	NN
cord-006860-a3b8hyyr	4562	18	and	and	CC
cord-006860-a3b8hyyr	4562	19	the	the	DT
cord-006860-a3b8hyyr	4562	20	incidence	incidence	NN
cord-006860-a3b8hyyr	4562	21	of	of	IN
cord-006860-a3b8hyyr	4562	22	venous	venous	JJ
cord-006860-a3b8hyyr	4562	23	thromboembolisrn	thromboembolisrn	NNS
cord-006860-a3b8hyyr	4562	24	was	be	VBD
cord-006860-a3b8hyyr	4562	25	examined	examine	VBN
cord-006860-a3b8hyyr	4562	26	using	use	VBG
cord-006860-a3b8hyyr	4562	27	different	different	JJ
cord-006860-a3b8hyyr	4562	28	regimes	regime	NNS
cord-006860-a3b8hyyr	4562	29	for	for	IN
cord-006860-a3b8hyyr	4562	30	heparin	heparin	JJ
cord-006860-a3b8hyyr	4562	31	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	4563	1	(	(	-LRB-
cord-006860-a3b8hyyr	4563	2	30	30	CD
cord-006860-a3b8hyyr	4563	3	patients	patient	NNS
cord-006860-a3b8hyyr	4563	4	received	receive	VBD
cord-006860-a3b8hyyr	4563	5	fraxiparin	fraxiparin	NNP
cord-006860-a3b8hyyr	4563	6	36	36	CD
cord-006860-a3b8hyyr	4563	7	rag	rag	NN
cord-006860-a3b8hyyr	4563	8	once	once	RB
cord-006860-a3b8hyyr	4563	9	daily	daily	RB
cord-006860-a3b8hyyr	4563	10	,	,	,
cord-006860-a3b8hyyr	4563	11	30	30	CD
cord-006860-a3b8hyyr	4563	12	patients	patient	NNS
cord-006860-a3b8hyyr	4563	13	clexane	clexane	NNP
cord-006860-a3b8hyyr	4563	14	40	40	CD
cord-006860-a3b8hyyr	4563	15	once	once	RB
cord-006860-a3b8hyyr	4563	16	daily	daily	JJ
cord-006860-a3b8hyyr	4563	17	and	and	CC
cord-006860-a3b8hyyr	4563	18	30	30	CD
cord-006860-a3b8hyyr	4563	19	patients	patient	NNS
cord-006860-a3b8hyyr	4563	20	7500	7500	CD
cord-006860-a3b8hyyr	4563	21	U	U	NNP
cord-006860-a3b8hyyr	4563	22	Calciparin	Calciparin	NNP
cord-006860-a3b8hyyr	4563	23	twice	twice	RB
cord-006860-a3b8hyyr	4563	24	daily	daily	RB
cord-006860-a3b8hyyr	4563	25	)	)	-RRB-
cord-006860-a3b8hyyr	4563	26	.	.	.
cord-006860-a3b8hyyr	4564	1	There	there	EX
cord-006860-a3b8hyyr	4564	2	were	be	VBD
cord-006860-a3b8hyyr	4564	3	no	no	DT
cord-006860-a3b8hyyr	4564	4	differences	difference	NNS
cord-006860-a3b8hyyr	4564	5	between	between	IN
cord-006860-a3b8hyyr	4564	6	the	the	DT
cord-006860-a3b8hyyr	4564	7	groups	group	NNS
cord-006860-a3b8hyyr	4564	8	concerning	concern	VBG
cord-006860-a3b8hyyr	4564	9	age	age	NN
cord-006860-a3b8hyyr	4564	10	,	,	,
cord-006860-a3b8hyyr	4564	11	sex	sex	NN
cord-006860-a3b8hyyr	4564	12	,	,	,
cord-006860-a3b8hyyr	4564	13	body	body	NN
cord-006860-a3b8hyyr	4564	14	weight	weight	NN
cord-006860-a3b8hyyr	4564	15	,	,	,
cord-006860-a3b8hyyr	4564	16	risk	risk	NN
cord-006860-a3b8hyyr	4564	17	factors	factor	NNS
cord-006860-a3b8hyyr	4564	18	,	,	,
cord-006860-a3b8hyyr	4564	19	surgeons	surgeon	NNS
cord-006860-a3b8hyyr	4564	20	,	,	,
cord-006860-a3b8hyyr	4564	21	decrease	decrease	VB
cord-006860-a3b8hyyr	4564	22	in	in	IN
cord-006860-a3b8hyyr	4564	23	hemoglobin~	hemoglobin~	NNP
cord-006860-a3b8hyyr	4564	24	and	and	CC
cord-006860-a3b8hyyr	4564	25	requirements	requirement	NNS
cord-006860-a3b8hyyr	4564	26	for	for	IN
cord-006860-a3b8hyyr	4564	27	blood	blood	NN
cord-006860-a3b8hyyr	4564	28	products	product	NNS
cord-006860-a3b8hyyr	4564	29	.	.	.
cord-006860-a3b8hyyr	4565	1	Pre	pre	JJ
cord-006860-a3b8hyyr	4565	2	surgery	surgery	NN
cord-006860-a3b8hyyr	4565	3	,	,	,
cord-006860-a3b8hyyr	4565	4	day	day	NN
cord-006860-a3b8hyyr	4565	5	1	1	CD
cord-006860-a3b8hyyr	4565	6	,	,	,
cord-006860-a3b8hyyr	4565	7	day	day	NN
cord-006860-a3b8hyyr	4565	8	5	5	CD
cord-006860-a3b8hyyr	4565	9	-	-	SYM
cord-006860-a3b8hyyr	4565	10	7	7	CD
cord-006860-a3b8hyyr	4565	11	phIebograms	phIebograms	NNPS
cord-006860-a3b8hyyr	4565	12	were	be	VBD
cord-006860-a3b8hyyr	4565	13	performed	perform	VBN
cord-006860-a3b8hyyr	4565	14	and	and	CC
cord-006860-a3b8hyyr	4565	15	also	also	RB
cord-006860-a3b8hyyr	4565	16	TAT	tat	NN
cord-006860-a3b8hyyr	4565	17	,	,	,
cord-006860-a3b8hyyr	4565	18	dimers	dimer	NNS
cord-006860-a3b8hyyr	4565	19	,	,	,
cord-006860-a3b8hyyr	4565	20	Fl+2	Fl+2	NNP
cord-006860-a3b8hyyr	4565	21	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4565	22	fragments	fragment	NNS
cord-006860-a3b8hyyr	4565	23	were	be	VBD
cord-006860-a3b8hyyr	4565	24	examined	examine	VBN
cord-006860-a3b8hyyr	4565	25	.	.	.
cord-006860-a3b8hyyr	4566	1	Results	result	NNS
cord-006860-a3b8hyyr	4566	2	:	:	:
cord-006860-a3b8hyyr	4566	3	1	1	CD
cord-006860-a3b8hyyr	4566	4	.	.	NN
cord-006860-a3b8hyyr	4566	5	,	,	,
cord-006860-a3b8hyyr	4566	6	DVT	DVT	NNP
cord-006860-a3b8hyyr	4566	7	in	in	IN
cord-006860-a3b8hyyr	4566	8	26	26	CD
cord-006860-a3b8hyyr	4566	9	patients	patient	NNS
cord-006860-a3b8hyyr	4566	10	(	(	-LRB-
cord-006860-a3b8hyyr	4566	11	28.9	28.9	CD
cord-006860-a3b8hyyr	4566	12	%	%	NN
cord-006860-a3b8hyyr	4566	13	)	)	-RRB-
cord-006860-a3b8hyyr	4566	14	.	.	.
cord-006860-a3b8hyyr	4567	1	DVT	DVT	NNP
cord-006860-a3b8hyyr	4567	2	in	in	IN
cord-006860-a3b8hyyr	4567	3	5/30	5/30	CD
cord-006860-a3b8hyyr	4567	4	patients	patient	NNS
cord-006860-a3b8hyyr	4567	5	under	under	IN
cord-006860-a3b8hyyr	4567	6	calciparm	calciparm	JJ
cord-006860-a3b8hyyr	4567	7	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	4567	8	,	,	,
cord-006860-a3b8hyyr	4567	9	8/30	8/30	CD
cord-006860-a3b8hyyr	4567	10	patients	patient	NNS
cord-006860-a3b8hyyr	4567	11	under	under	IN
cord-006860-a3b8hyyr	4567	12	fraxiparin	fraxiparin	NNP
cord-006860-a3b8hyyr	4567	13	and	and	CC
cord-006860-a3b8hyyr	4567	14	13/30	13/30	CD
cord-006860-a3b8hyyr	4567	15	patients	patient	NNS
cord-006860-a3b8hyyr	4567	16	under	under	IN
cord-006860-a3b8hyyr	4567	17	clexane	clexane	NNP
cord-006860-a3b8hyyr	4567	18	treatment	treatment	NN
cord-006860-a3b8hyyr	4567	19	.	.	.
cord-006860-a3b8hyyr	4568	1	2	2	LS
cord-006860-a3b8hyyr	4568	2	.	.	.
cord-006860-a3b8hyyr	4568	3	,	,	,
cord-006860-a3b8hyyr	4568	4	Low	low	JJ
cord-006860-a3b8hyyr	4568	5	speciflty	speciflty	NN
cord-006860-a3b8hyyr	4568	6	(	(	-LRB-
cord-006860-a3b8hyyr	4568	7	3.4	3.4	CD
cord-006860-a3b8hyyr	4568	8	%	%	NN
cord-006860-a3b8hyyr	4568	9	)	)	-RRB-
cord-006860-a3b8hyyr	4568	10	of	of	IN
cord-006860-a3b8hyyr	4568	11	dimers	dimer	NNS
cord-006860-a3b8hyyr	4568	12	and	and	CC
cord-006860-a3b8hyyr	4568	13	TAT	TAT	NNP
cord-006860-a3b8hyyr	4568	14	(	(	-LRB-
cord-006860-a3b8hyyr	4568	15	24	24	CD
cord-006860-a3b8hyyr	4568	16	%	%	NN
cord-006860-a3b8hyyr	4568	17	)	)	-RRB-
cord-006860-a3b8hyyr	4568	18	for	for	IN
cord-006860-a3b8hyyr	4568	19	detecting	detect	VBG
cord-006860-a3b8hyyr	4568	20	a	a	DT
cord-006860-a3b8hyyr	4568	21	DVT	DVT	NNP
cord-006860-a3b8hyyr	4568	22	in	in	IN
cord-006860-a3b8hyyr	4568	23	these	these	DT
cord-006860-a3b8hyyr	4568	24	special	special	JJ
cord-006860-a3b8hyyr	4568	25	patients	patient	NNS
cord-006860-a3b8hyyr	4568	26	undergoing	undergo	VBG
cord-006860-a3b8hyyr	4568	27	knee	knee	NN
cord-006860-a3b8hyyr	4568	28	replacement	replacement	NN
cord-006860-a3b8hyyr	4568	29	therapy	therapy	NN
cord-006860-a3b8hyyr	4568	30	,	,	,
cord-006860-a3b8hyyr	4568	31	elevated	elevate	VBN
cord-006860-a3b8hyyr	4568	32	FI+2	fi+2	NN
cord-006860-a3b8hyyr	4568	33	fragments	fragment	NNS
cord-006860-a3b8hyyr	4568	34	in	in	IN
cord-006860-a3b8hyyr	4568	35	the	the	DT
cord-006860-a3b8hyyr	4568	36	DVT	DVT	NNP
cord-006860-a3b8hyyr	4568	37	group	group	NN
cord-006860-a3b8hyyr	4568	38	at	at	IN
cord-006860-a3b8hyyr	4568	39	TI	TI	NNP
cord-006860-a3b8hyyr	4568	40	and	and	CC
cord-006860-a3b8hyyr	4568	41	T2	T2	NNP
cord-006860-a3b8hyyr	4568	42	vs	vs	IN
cord-006860-a3b8hyyr	4568	43	the	the	DT
cord-006860-a3b8hyyr	4568	44	patients	patient	NNS
cord-006860-a3b8hyyr	4568	45	without	without	IN
cord-006860-a3b8hyyr	4568	46	DVT	DVT	NNP
cord-006860-a3b8hyyr	4568	47	(	(	-LRB-
cord-006860-a3b8hyyr	4568	48	T1	T1	NNP
cord-006860-a3b8hyyr	4568	49	DVT	DVT	NNP
cord-006860-a3b8hyyr	4568	50	:	:	:
cord-006860-a3b8hyyr	4569	1	3.24	3.24	CD
cord-006860-a3b8hyyr	4569	2	+	+	SYM
cord-006860-a3b8hyyr	4569	3	-1.8	-1.8	CD
cord-006860-a3b8hyyr	4569	4	vs.	vs.	IN
cord-006860-a3b8hyyr	4569	5	1.6	1.6	CD
cord-006860-a3b8hyyr	4569	6	+	+	CD
cord-006860-a3b8hyyr	4569	7	-0.3	-0.3	JJ
cord-006860-a3b8hyyr	4569	8	-p=	-p=	NNP
cord-006860-a3b8hyyr	4569	9	0.0042	0.0042	CD
cord-006860-a3b8hyyr	4569	10	)	)	-RRB-
cord-006860-a3b8hyyr	4569	11	.	.	.
cord-006860-a3b8hyyr	4570	1	3	3	LS
cord-006860-a3b8hyyr	4570	2	,	,	,
cord-006860-a3b8hyyr	4570	3	Only	only	RB
cord-006860-a3b8hyyr	4570	4	8/26	8/26	CD
cord-006860-a3b8hyyr	4570	5	patients	patient	NNS
cord-006860-a3b8hyyr	4570	6	(	(	-LRB-
cord-006860-a3b8hyyr	4570	7	31	31	CD
cord-006860-a3b8hyyr	4570	8	%	%	NN
cord-006860-a3b8hyyr	4570	9	)	)	-RRB-
cord-006860-a3b8hyyr	4570	10	with	with	IN
cord-006860-a3b8hyyr	4570	11	DVT	DVT	NNP
cord-006860-a3b8hyyr	4570	12	had	have	VBD
cord-006860-a3b8hyyr	4570	13	clinical	clinical	JJ
cord-006860-a3b8hyyr	4570	14	signs	sign	NNS
cord-006860-a3b8hyyr	4570	15	of	of	IN
cord-006860-a3b8hyyr	4570	16	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4570	17	.	.	.
cord-006860-a3b8hyyr	4571	1	Conclusions	conclusion	NNS
cord-006860-a3b8hyyr	4571	2	:	:	:
cord-006860-a3b8hyyr	4572	1	1	1	LS
cord-006860-a3b8hyyr	4572	2	.	.	.
cord-006860-a3b8hyyr	4572	3	,	,	,
cord-006860-a3b8hyyr	4572	4	There	there	EX
cord-006860-a3b8hyyr	4572	5	is	be	VBZ
cord-006860-a3b8hyyr	4572	6	an	an	DT
cord-006860-a3b8hyyr	4572	7	increase	increase	NN
cord-006860-a3b8hyyr	4572	8	of	of	IN
cord-006860-a3b8hyyr	4572	9	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	4572	10	gneeration	gneeration	NN
cord-006860-a3b8hyyr	4572	11	measured	measure	VBN
cord-006860-a3b8hyyr	4572	12	by	by	IN
cord-006860-a3b8hyyr	4572	13	TAT	TAT	NNP
cord-006860-a3b8hyyr	4572	14	and	and	CC
cord-006860-a3b8hyyr	4572	15	dimers	dimer	NNS
cord-006860-a3b8hyyr	4572	16	after	after	IN
cord-006860-a3b8hyyr	4572	17	knee	knee	NN
cord-006860-a3b8hyyr	4572	18	replacement	replacement	NN
cord-006860-a3b8hyyr	4572	19	therapy	therapy	NN
cord-006860-a3b8hyyr	4572	20	.	.	.
cord-006860-a3b8hyyr	4573	1	There	there	EX
cord-006860-a3b8hyyr	4573	2	are	be	VBP
cord-006860-a3b8hyyr	4573	3	further	further	JJ
cord-006860-a3b8hyyr	4573	4	studies	study	NNS
cord-006860-a3b8hyyr	4573	5	with	with	IN
cord-006860-a3b8hyyr	4573	6	more	more	JJR
cord-006860-a3b8hyyr	4573	7	patients	patient	NNS
cord-006860-a3b8hyyr	4573	8	necessary	necessary	JJ
cord-006860-a3b8hyyr	4573	9	to	to	TO
cord-006860-a3b8hyyr	4573	10	confirm	confirm	VB
cord-006860-a3b8hyyr	4573	11	that	that	IN
cord-006860-a3b8hyyr	4573	12	Fl+2	Fl+2	NNP
cord-006860-a3b8hyyr	4573	13	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4573	14	fragments	fragment	NNS
cord-006860-a3b8hyyr	4573	15	can	can	MD
cord-006860-a3b8hyyr	4573	16	discriminate	discriminate	VB
cord-006860-a3b8hyyr	4573	17	between	between	IN
cord-006860-a3b8hyyr	4573	18	patients	patient	NNS
cord-006860-a3b8hyyr	4573	19	with	with	IN
cord-006860-a3b8hyyr	4573	20	and	and	CC
cord-006860-a3b8hyyr	4573	21	without	without	IN
cord-006860-a3b8hyyr	4573	22	DVT	DVT	NNP
cord-006860-a3b8hyyr	4573	23	from	from	IN
cord-006860-a3b8hyyr	4573	24	a	a	DT
cord-006860-a3b8hyyr	4573	25	clinician	clinician	NN
cord-006860-a3b8hyyr	4573	26	's	's	POS
cord-006860-a3b8hyyr	4573	27	point	point	NN
cord-006860-a3b8hyyr	4573	28	of	of	IN
cord-006860-a3b8hyyr	4573	29	view	view	NN
cord-006860-a3b8hyyr	4573	30	.	.	.
cord-006860-a3b8hyyr	4574	1	2	2	LS
cord-006860-a3b8hyyr	4574	2	.	.	.
cord-006860-a3b8hyyr	4574	3	,	,	,
cord-006860-a3b8hyyr	4574	4	PhlebographicaUy	PhlebographicaUy	NNP
cord-006860-a3b8hyyr	4574	5	confimled	confimle	VBD
cord-006860-a3b8hyyr	4574	6	DVT	DVT	NNP
cord-006860-a3b8hyyr	4574	7	in	in	IN
cord-006860-a3b8hyyr	4574	8	almost	almost	RB
cord-006860-a3b8hyyr	4574	9	30	30	CD
cord-006860-a3b8hyyr	4574	10	%	%	NN
cord-006860-a3b8hyyr	4574	11	of	of	IN
cord-006860-a3b8hyyr	4574	12	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4574	13	patients	patient	NNS
cord-006860-a3b8hyyr	4574	14	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	4574	15	the	the	DT
cord-006860-a3b8hyyr	4574	16	high	high	JJ
cord-006860-a3b8hyyr	4574	17	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	4574	18	risk	risk	NN
cord-006860-a3b8hyyr	4574	19	in	in	IN
cord-006860-a3b8hyyr	4574	20	these	these	DT
cord-006860-a3b8hyyr	4574	21	patients	patient	NNS
cord-006860-a3b8hyyr	4574	22	.	.	.
cord-006860-a3b8hyyr	4575	1	Von	Von	NNP
cord-006860-a3b8hyyr	4575	2	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	4575	3	's	's	POS
cord-006860-a3b8hyyr	4575	4	disease	disease	NN
cord-006860-a3b8hyyr	4575	5	(	(	-LRB-
cord-006860-a3b8hyyr	4575	6	VWD	VWD	NNP
cord-006860-a3b8hyyr	4575	7	)	)	-RRB-
cord-006860-a3b8hyyr	4575	8	type	type	NN
cord-006860-a3b8hyyr	4575	9	2	2	CD
cord-006860-a3b8hyyr	4575	10	is	be	VBZ
cord-006860-a3b8hyyr	4575	11	characterized	characterize	VBN
cord-006860-a3b8hyyr	4575	12	by	by	IN
cord-006860-a3b8hyyr	4575	13	absence	absence	NN
cord-006860-a3b8hyyr	4575	14	of	of	IN
cord-006860-a3b8hyyr	4575	15	high	high	JJ
cord-006860-a3b8hyyr	4575	16	molecular	molecular	JJ
cord-006860-a3b8hyyr	4575	17	weight	weight	NN
cord-006860-a3b8hyyr	4575	18	muitimers	muitimer	NNS
cord-006860-a3b8hyyr	4575	19	.	.	.
cord-006860-a3b8hyyr	4576	1	Qualitative	qualitative	JJ
cord-006860-a3b8hyyr	4576	2	changes	change	NNS
cord-006860-a3b8hyyr	4576	3	in	in	IN
cord-006860-a3b8hyyr	4576	4	the	the	DT
cord-006860-a3b8hyyr	4576	5	structure	structure	NN
cord-006860-a3b8hyyr	4576	6	of	of	IN
cord-006860-a3b8hyyr	4576	7	the	the	DT
cord-006860-a3b8hyyr	4576	8	molecule	molecule	NN
cord-006860-a3b8hyyr	4576	9	might	may	MD
cord-006860-a3b8hyyr	4576	10	be	be	VB
cord-006860-a3b8hyyr	4576	11	associated	associate	VBN
cord-006860-a3b8hyyr	4576	12	with	with	IN
cord-006860-a3b8hyyr	4576	13	enhanced	enhanced	JJ
cord-006860-a3b8hyyr	4576	14	binding	binding	NN
cord-006860-a3b8hyyr	4576	15	of	of	IN
cord-006860-a3b8hyyr	4576	16	von	von	NNP
cord-006860-a3b8hyyr	4576	17	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	4576	18	factor	factor	NN
cord-006860-a3b8hyyr	4576	19	(	(	-LRB-
cord-006860-a3b8hyyr	4576	20	VWF	VWF	NNP
cord-006860-a3b8hyyr	4576	21	)	)	-RRB-
cord-006860-a3b8hyyr	4576	22	to	to	IN
cord-006860-a3b8hyyr	4576	23	platelet	platelet	NN
cord-006860-a3b8hyyr	4576	24	glycoprotein	glycoprotein	NN
cord-006860-a3b8hyyr	4576	25	lb	lb	IN
cord-006860-a3b8hyyr	4576	26	.	.	.
cord-006860-a3b8hyyr	4577	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	4577	2	in	in	IN
cord-006860-a3b8hyyr	4577	3	some	some	DT
cord-006860-a3b8hyyr	4577	4	patients	patient	NNS
cord-006860-a3b8hyyr	4577	5	VWD	VWD	NNP
cord-006860-a3b8hyyr	4577	6	type	type	NN
cord-006860-a3b8hyyr	4577	7	2	2	CD
cord-006860-a3b8hyyr	4577	8	is	be	VBZ
cord-006860-a3b8hyyr	4577	9	associated	associate	VBN
cord-006860-a3b8hyyr	4577	10	with	with	IN
cord-006860-a3b8hyyr	4577	11	severe	severe	JJ
cord-006860-a3b8hyyr	4577	12	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	4577	13	.	.	.
cord-006860-a3b8hyyr	4578	1	Here	here	RB
cord-006860-a3b8hyyr	4578	2	,	,	,
cord-006860-a3b8hyyr	4578	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	4578	4	report	report	VBP
cord-006860-a3b8hyyr	4578	5	on	on	IN
cord-006860-a3b8hyyr	4578	6	a	a	DT
cord-006860-a3b8hyyr	4578	7	9	9	CD
cord-006860-a3b8hyyr	4578	8	year	year	NN
cord-006860-a3b8hyyr	4578	9	old	old	JJ
cord-006860-a3b8hyyr	4578	10	boy	boy	NN
cord-006860-a3b8hyyr	4578	11	who	who	WP
cord-006860-a3b8hyyr	4578	12	presented	present	VBD
cord-006860-a3b8hyyr	4578	13	with	with	IN
cord-006860-a3b8hyyr	4578	14	severe	severe	JJ
cord-006860-a3b8hyyr	4578	15	purpura	purpura	NN
cord-006860-a3b8hyyr	4578	16	and	and	CC
cord-006860-a3b8hyyr	4578	17	platelet	platelet	NN
cord-006860-a3b8hyyr	4578	18	counts	count	VBZ
cord-006860-a3b8hyyr	4578	19	about	about	RB
cord-006860-a3b8hyyr	4578	20	20000	20000	CD
cord-006860-a3b8hyyr	4578	21	/	/	SYM
cord-006860-a3b8hyyr	4578	22	gl	gl	NN
cord-006860-a3b8hyyr	4578	23	at	at	IN
cord-006860-a3b8hyyr	4578	24	the	the	DT
cord-006860-a3b8hyyr	4578	25	age	age	NN
cord-006860-a3b8hyyr	4578	26	of	of	IN
cord-006860-a3b8hyyr	4578	27	2	2	CD
cord-006860-a3b8hyyr	4578	28	years	year	NNS
cord-006860-a3b8hyyr	4578	29	.	.	.
cord-006860-a3b8hyyr	4579	1	Thrombocytopenia	Thrombocytopenia	NNP
cord-006860-a3b8hyyr	4579	2	did	do	VBD
cord-006860-a3b8hyyr	4579	3	not	not	RB
cord-006860-a3b8hyyr	4579	4	respond	respond	VB
cord-006860-a3b8hyyr	4579	5	to	to	IN
cord-006860-a3b8hyyr	4579	6	corticosteroids	corticosteroid	NNS
cord-006860-a3b8hyyr	4579	7	.	.	.
cord-006860-a3b8hyyr	4580	1	A	a	DT
cord-006860-a3b8hyyr	4580	2	normalized	normalized	JJ
cord-006860-a3b8hyyr	4580	3	platelet	platelet	NN
cord-006860-a3b8hyyr	4580	4	count	count	NN
cord-006860-a3b8hyyr	4580	5	of	of	IN
cord-006860-a3b8hyyr	4580	6	short	short	JJ
cord-006860-a3b8hyyr	4580	7	duration	duration	NN
cord-006860-a3b8hyyr	4580	8	was	be	VBD
cord-006860-a3b8hyyr	4580	9	observed	observe	VBN
cord-006860-a3b8hyyr	4580	10	after	after	IN
cord-006860-a3b8hyyr	4580	11	high	high	JJ
cord-006860-a3b8hyyr	4580	12	-	-	HYPH
cord-006860-a3b8hyyr	4580	13	dose	dose	NN
cord-006860-a3b8hyyr	4580	14	immunoglobulins	immunoglobulin	NNS
cord-006860-a3b8hyyr	4580	15	.	.	.
cord-006860-a3b8hyyr	4581	1	In	in	IN
cord-006860-a3b8hyyr	4581	2	addition	addition	NN
cord-006860-a3b8hyyr	4581	3	,	,	,
cord-006860-a3b8hyyr	4581	4	increase	increase	NN
cord-006860-a3b8hyyr	4581	5	of	of	IN
cord-006860-a3b8hyyr	4581	6	platelets	platelet	NNS
cord-006860-a3b8hyyr	4581	7	was	be	VBD
cord-006860-a3b8hyyr	4581	8	seen	see	VBN
cord-006860-a3b8hyyr	4581	9	after	after	IN
cord-006860-a3b8hyyr	4581	10	anti	anti	JJ
cord-006860-a3b8hyyr	4581	11	-	-	JJ
cord-006860-a3b8hyyr	4581	12	D	d	JJ
cord-006860-a3b8hyyr	4581	13	treatment	treatment	NN
cord-006860-a3b8hyyr	4581	14	.	.	.
cord-006860-a3b8hyyr	4582	1	Thus	thus	RB
cord-006860-a3b8hyyr	4582	2	,	,	,
cord-006860-a3b8hyyr	4582	3	although	although	IN
cord-006860-a3b8hyyr	4582	4	platelet	platelet	NN
cord-006860-a3b8hyyr	4582	5	associated	associate	VBN
cord-006860-a3b8hyyr	4582	6	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4582	7	were	be	VBD
cord-006860-a3b8hyyr	4582	8	not	not	RB
cord-006860-a3b8hyyr	4582	9	detected	detect	VBN
cord-006860-a3b8hyyr	4582	10	,	,	,
cord-006860-a3b8hyyr	4582	11	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	4582	12	seemed	seem	VBD
cord-006860-a3b8hyyr	4582	13	to	to	TO
cord-006860-a3b8hyyr	4582	14	be	be	VB
cord-006860-a3b8hyyr	4582	15	caused	cause	VBN
cord-006860-a3b8hyyr	4582	16	by	by	IN
cord-006860-a3b8hyyr	4582	17	an	an	DT
cord-006860-a3b8hyyr	4582	18	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	4582	19	mechanism	mechanism	NN
cord-006860-a3b8hyyr	4582	20	.	.	.
cord-006860-a3b8hyyr	4583	1	Despite	despite	IN
cord-006860-a3b8hyyr	4583	2	platelet	platelet	NN
cord-006860-a3b8hyyr	4583	3	counts	count	NNS
cord-006860-a3b8hyyr	4583	4	above	above	IN
cord-006860-a3b8hyyr	4583	5	50000	50000	CD
cord-006860-a3b8hyyr	4583	6	/	/	SYM
cord-006860-a3b8hyyr	4583	7	gl	gl	NNP
cord-006860-a3b8hyyr	4583	8	,	,	,
cord-006860-a3b8hyyr	4583	9	the	the	DT
cord-006860-a3b8hyyr	4583	10	patient	patient	NN
cord-006860-a3b8hyyr	4583	11	experienced	experience	VBD
cord-006860-a3b8hyyr	4583	12	severe	severe	JJ
cord-006860-a3b8hyyr	4583	13	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	4583	14	with	with	IN
cord-006860-a3b8hyyr	4583	15	a	a	DT
cord-006860-a3b8hyyr	4583	16	significant	significant	JJ
cord-006860-a3b8hyyr	4583	17	decrease	decrease	NN
cord-006860-a3b8hyyr	4583	18	of	of	IN
cord-006860-a3b8hyyr	4583	19	hemoglobin	hemoglobin	NN
cord-006860-a3b8hyyr	4583	20	levels	level	NNS
cord-006860-a3b8hyyr	4583	21	.	.	.
cord-006860-a3b8hyyr	4584	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	4584	2	,	,	,
cord-006860-a3b8hyyr	4584	3	he	-PRON-	PRP
cord-006860-a3b8hyyr	4584	4	needed	need	VBD
cord-006860-a3b8hyyr	4584	5	several	several	JJ
cord-006860-a3b8hyyr	4584	6	transfusions	transfusion	NNS
cord-006860-a3b8hyyr	4584	7	.	.	.
cord-006860-a3b8hyyr	4585	1	Coagulation	coagulation	NN
cord-006860-a3b8hyyr	4585	2	analysis	analysis	NN
cord-006860-a3b8hyyr	4585	3	revealed	reveal	VBD
cord-006860-a3b8hyyr	4585	4	VWD	VWD	NNP
cord-006860-a3b8hyyr	4585	5	.	.	.
cord-006860-a3b8hyyr	4586	1	Application	application	NN
cord-006860-a3b8hyyr	4586	2	of	of	IN
cord-006860-a3b8hyyr	4586	3	DDAVP	DDAVP	NNP
cord-006860-a3b8hyyr	4586	4	lead	lead	NN
cord-006860-a3b8hyyr	4586	5	to	to	IN
cord-006860-a3b8hyyr	4586	6	a	a	DT
cord-006860-a3b8hyyr	4586	7	normalization	normalization	NN
cord-006860-a3b8hyyr	4586	8	of	of	IN
cord-006860-a3b8hyyr	4586	9	partial	partial	JJ
cord-006860-a3b8hyyr	4586	10	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	4586	11	time	time	NN
cord-006860-a3b8hyyr	4586	12	(	(	-LRB-
cord-006860-a3b8hyyr	4586	13	PTT	PTT	NNP
cord-006860-a3b8hyyr	4586	14	)	)	-RRB-
cord-006860-a3b8hyyr	4586	15	and	and	CC
cord-006860-a3b8hyyr	4586	16	an	an	DT
cord-006860-a3b8hyyr	4586	17	increase	increase	NN
cord-006860-a3b8hyyr	4586	18	of	of	IN
cord-006860-a3b8hyyr	4586	19	factor	factor	NN
cord-006860-a3b8hyyr	4586	20	VIII	VIII	NNP
cord-006860-a3b8hyyr	4586	21	with	with	IN
cord-006860-a3b8hyyr	4586	22	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	4586	23	cessation	cessation	NN
cord-006860-a3b8hyyr	4586	24	of	of	IN
cord-006860-a3b8hyyr	4586	25	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4586	26	symptoms	symptom	NNS
cord-006860-a3b8hyyr	4586	27	.	.	.
cord-006860-a3b8hyyr	4587	1	Recently	recently	RB
cord-006860-a3b8hyyr	4587	2	,	,	,
cord-006860-a3b8hyyr	4587	3	VWD	VWD	NNP
cord-006860-a3b8hyyr	4587	4	was	be	VBD
cord-006860-a3b8hyyr	4587	5	typed	type	VBN
cord-006860-a3b8hyyr	4587	6	2	2	CD
cord-006860-a3b8hyyr	4587	7	by	by	IN
cord-006860-a3b8hyyr	4587	8	lack	lack	NN
cord-006860-a3b8hyyr	4587	9	of	of	IN
cord-006860-a3b8hyyr	4587	10	high	high	JJ
cord-006860-a3b8hyyr	4587	11	molecular	molecular	JJ
cord-006860-a3b8hyyr	4587	12	weight	weight	NN
cord-006860-a3b8hyyr	4587	13	multimers	multimer	NNS
cord-006860-a3b8hyyr	4587	14	.	.	.
cord-006860-a3b8hyyr	4588	1	In	in	IN
cord-006860-a3b8hyyr	4588	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	4588	3	,	,	,
cord-006860-a3b8hyyr	4588	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	4588	5	report	report	VBP
cord-006860-a3b8hyyr	4588	6	a	a	DT
cord-006860-a3b8hyyr	4588	7	case	case	NN
cord-006860-a3b8hyyr	4588	8	with	with	IN
cord-006860-a3b8hyyr	4588	9	VWD	VWD	NNP
cord-006860-a3b8hyyr	4588	10	type	type	NN
cord-006860-a3b8hyyr	4588	11	2	2	CD
cord-006860-a3b8hyyr	4588	12	responding	respond	VBG
cord-006860-a3b8hyyr	4588	13	to	to	IN
cord-006860-a3b8hyyr	4588	14	DDAVP	DDAVP	NNP
cord-006860-a3b8hyyr	4588	15	.	.	.
cord-006860-a3b8hyyr	4589	1	However	however	RB
cord-006860-a3b8hyyr	4589	2	it	-PRON-	PRP
cord-006860-a3b8hyyr	4589	3	is	be	VBZ
cord-006860-a3b8hyyr	4589	4	unclear	unclear	JJ
cord-006860-a3b8hyyr	4589	5	,	,	,
cord-006860-a3b8hyyr	4589	6	whether	whether	IN
cord-006860-a3b8hyyr	4589	7	thrombocytopenia	thrombocytopenia	NN
cord-006860-a3b8hyyr	4589	8	is	be	VBZ
cord-006860-a3b8hyyr	4589	9	part	part	NN
cord-006860-a3b8hyyr	4589	10	of	of	IN
cord-006860-a3b8hyyr	4589	11	the	the	DT
cord-006860-a3b8hyyr	4589	12	VWD	VWD	NNP
cord-006860-a3b8hyyr	4589	13	type	type	NN
cord-006860-a3b8hyyr	4589	14	2	2	CD
cord-006860-a3b8hyyr	4589	15	or	or	CC
cord-006860-a3b8hyyr	4589	16	of	of	IN
cord-006860-a3b8hyyr	4589	17	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	4589	18	origin	origin	NN
cord-006860-a3b8hyyr	4589	19	.	.	.
cord-006860-a3b8hyyr	4590	1	Since	since	IN
cord-006860-a3b8hyyr	4590	2	autoimmune	autoimmune	JJ
cord-006860-a3b8hyyr	4590	3	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4590	4	have	have	VBP
cord-006860-a3b8hyyr	4590	5	not	not	RB
cord-006860-a3b8hyyr	4590	6	been	be	VBN
cord-006860-a3b8hyyr	4590	7	detected	detect	VBN
cord-006860-a3b8hyyr	4590	8	,	,	,
cord-006860-a3b8hyyr	4590	9	the	the	DT
cord-006860-a3b8hyyr	4590	10	effect	effect	NN
cord-006860-a3b8hyyr	4590	11	of	of	IN
cord-006860-a3b8hyyr	4590	12	immunoglobulin	immunoglobulin	NN
cord-006860-a3b8hyyr	4590	13	treatment	treatment	NN
cord-006860-a3b8hyyr	4590	14	might	may	MD
cord-006860-a3b8hyyr	4590	15	be	be	VB
cord-006860-a3b8hyyr	4590	16	explained	explain	VBN
cord-006860-a3b8hyyr	4590	17	by	by	IN
cord-006860-a3b8hyyr	4590	18	blockade	blockade	NN
cord-006860-a3b8hyyr	4590	19	of	of	IN
cord-006860-a3b8hyyr	4590	20	enhanced	enhance	VBN
cord-006860-a3b8hyyr	4590	21	binding	binding	NN
cord-006860-a3b8hyyr	4590	22	of	of	IN
cord-006860-a3b8hyyr	4590	23	VWF	VWF	NNP
cord-006860-a3b8hyyr	4590	24	to	to	IN
cord-006860-a3b8hyyr	4590	25	glycoprotein	glycoprotein	NN
cord-006860-a3b8hyyr	4590	26	lb	lb	IN
cord-006860-a3b8hyyr	4590	27	.	.	.
cord-006860-a3b8hyyr	4591	1	Von	Von	NNP
cord-006860-a3b8hyyr	4591	2	Willebrad	Willebrad	NNP
cord-006860-a3b8hyyr	4591	3	disease	disease	NN
cord-006860-a3b8hyyr	4591	4	(	(	-LRB-
cord-006860-a3b8hyyr	4591	5	vWd	vWd	NNS
cord-006860-a3b8hyyr	4591	6	)	)	-RRB-
cord-006860-a3b8hyyr	4591	7	with	with	IN
cord-006860-a3b8hyyr	4591	8	a	a	DT
cord-006860-a3b8hyyr	4591	9	prevalence	prevalence	NN
cord-006860-a3b8hyyr	4591	10	of	of	IN
cord-006860-a3b8hyyr	4591	11	0,8	0,8	CD
cord-006860-a3b8hyyr	4591	12	%	%	NN
cord-006860-a3b8hyyr	4591	13	(	(	-LRB-
cord-006860-a3b8hyyr	4591	14	Ruggeri	Ruggeri	NNP
cord-006860-a3b8hyyr	4591	15	1994	1994	CD
cord-006860-a3b8hyyr	4591	16	,	,	,
cord-006860-a3b8hyyr	4591	17	Rodeignere	Rodeignere	NNP
cord-006860-a3b8hyyr	4591	18	1987	1987	CD
cord-006860-a3b8hyyr	4591	19	)	)	-RRB-
cord-006860-a3b8hyyr	4591	20	seems	seem	VBZ
cord-006860-a3b8hyyr	4591	21	to	to	TO
cord-006860-a3b8hyyr	4591	22	be	be	VB
cord-006860-a3b8hyyr	4591	23	the	the	DT
cord-006860-a3b8hyyr	4591	24	most	most	RBS
cord-006860-a3b8hyyr	4591	25	frequent	frequent	JJ
cord-006860-a3b8hyyr	4591	26	inherited	inherit	VBN
cord-006860-a3b8hyyr	4591	27	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	4591	28	disorder	disorder	NN
cord-006860-a3b8hyyr	4591	29	.	.	.
cord-006860-a3b8hyyr	4592	1	•	•	NNP
cord-006860-a3b8hyyr	4593	1	The	the	DT
cord-006860-a3b8hyyr	4593	2	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	4593	3	criteria	criterion	NNS
cord-006860-a3b8hyyr	4593	4	for	for	IN
cord-006860-a3b8hyyr	4593	5	vWd	vWd	NNS
cord-006860-a3b8hyyr	4593	6	are	be	VBP
cord-006860-a3b8hyyr	4593	7	clinical	clinical	JJ
cord-006860-a3b8hyyr	4593	8	picture	picture	NN
cord-006860-a3b8hyyr	4593	9	,	,	,
cord-006860-a3b8hyyr	4593	10	family	family	NN
cord-006860-a3b8hyyr	4593	11	hostory	hostory	NNP
cord-006860-a3b8hyyr	4593	12	,	,	,
cord-006860-a3b8hyyr	4593	13	laboratory	laboratory	NN
cord-006860-a3b8hyyr	4593	14	findings	finding	NNS
cord-006860-a3b8hyyr	4593	15	:	:	:
cord-006860-a3b8hyyr	4593	16	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4593	17	time	time	NN
cord-006860-a3b8hyyr	4593	18	,	,	,
cord-006860-a3b8hyyr	4593	19	partial	partial	JJ
cord-006860-a3b8hyyr	4593	20	tromboplastine	tromboplastine	NN
cord-006860-a3b8hyyr	4593	21	time	time	NN
cord-006860-a3b8hyyr	4593	22	(	(	-LRB-
cord-006860-a3b8hyyr	4593	23	PTT	PTT	NNP
cord-006860-a3b8hyyr	4593	24	)	)	-RRB-
cord-006860-a3b8hyyr	4593	25	,	,	,
cord-006860-a3b8hyyr	4593	26	level	level	NN
cord-006860-a3b8hyyr	4593	27	of	of	IN
cord-006860-a3b8hyyr	4593	28	factor	factor	NN
cord-006860-a3b8hyyr	4593	29	VIII	VIII	NNP
cord-006860-a3b8hyyr	4593	30	:	:	:
cord-006860-a3b8hyyr	4593	31	e	e	NNP
cord-006860-a3b8hyyr	4593	32	,	,	,
cord-006860-a3b8hyyr	4593	33	vWF	vWF	NNP
cord-006860-a3b8hyyr	4593	34	,	,	,
cord-006860-a3b8hyyr	4593	35	vWF	vwf	XX
cord-006860-a3b8hyyr	4593	36	:	:	:
cord-006860-a3b8hyyr	4594	1	Ag	Ag	NNP
cord-006860-a3b8hyyr	4594	2	,	,	,
cord-006860-a3b8hyyr	4594	3	ristocetin	ristocetin	JJ
cord-006860-a3b8hyyr	4594	4	induced	induce	VBN
cord-006860-a3b8hyyr	4594	5	platelets	platelet	NNS
cord-006860-a3b8hyyr	4594	6	aggregation	aggregation	NN
cord-006860-a3b8hyyr	4594	7	(	(	-LRB-
cord-006860-a3b8hyyr	4594	8	RIPA	RIPA	NNP
cord-006860-a3b8hyyr	4594	9	)	)	-RRB-
cord-006860-a3b8hyyr	4594	10	and	and	CC
cord-006860-a3b8hyyr	4594	11	multim~-analysis	multim~-analysis	NNP
cord-006860-a3b8hyyr	4594	12	.	.	.
cord-006860-a3b8hyyr	4595	1	The	the	DT
cord-006860-a3b8hyyr	4595	2	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	4595	3	ofvWd	ofvwd	PRP
cord-006860-a3b8hyyr	4595	4	is	be	VBZ
cord-006860-a3b8hyyr	4595	5	occasionally	occasionally	RB
cord-006860-a3b8hyyr	4595	6	difficult	difficult	JJ
cord-006860-a3b8hyyr	4595	7	,	,	,
cord-006860-a3b8hyyr	4595	8	especially	especially	RB
cord-006860-a3b8hyyr	4595	9	in	in	IN
cord-006860-a3b8hyyr	4595	10	early	early	JJ
cord-006860-a3b8hyyr	4595	11	childhood	childhood	NN
cord-006860-a3b8hyyr	4595	12	because	because	IN
cord-006860-a3b8hyyr	4595	13	the	the	DT
cord-006860-a3b8hyyr	4595	14	laboratory	laboratory	NN
cord-006860-a3b8hyyr	4595	15	data	datum	NNS
cord-006860-a3b8hyyr	4595	16	may	may	MD
cord-006860-a3b8hyyr	4595	17	vary	vary	VB
cord-006860-a3b8hyyr	4595	18	due	due	IN
cord-006860-a3b8hyyr	4595	19	to	to	IN
cord-006860-a3b8hyyr	4595	20	time	time	NN
cord-006860-a3b8hyyr	4595	21	of	of	IN
cord-006860-a3b8hyyr	4595	22	investigation	investigation	NN
cord-006860-a3b8hyyr	4595	23	,	,	,
cord-006860-a3b8hyyr	4595	24	as	as	RB
cord-006860-a3b8hyyr	4595	25	well	well	RB
cord-006860-a3b8hyyr	4595	26	as	as	IN
cord-006860-a3b8hyyr	4595	27	abnormalities	abnormality	NNS
cord-006860-a3b8hyyr	4595	28	may	may	MD
cord-006860-a3b8hyyr	4595	29	not	not	RB
cord-006860-a3b8hyyr	4595	30	be	be	VB
cord-006860-a3b8hyyr	4595	31	present	present	JJ
cord-006860-a3b8hyyr	4595	32	in	in	IN
cord-006860-a3b8hyyr	4595	33	all	all	DT
cord-006860-a3b8hyyr	4595	34	sub	sub	NN
cord-006860-a3b8hyyr	4595	35	-	-	NNS
cord-006860-a3b8hyyr	4595	36	types	type	NNS
cord-006860-a3b8hyyr	4596	1	The	the	DT
cord-006860-a3b8hyyr	4596	2	aim	aim	NN
cord-006860-a3b8hyyr	4596	3	of	of	IN
cord-006860-a3b8hyyr	4596	4	this	this	DT
cord-006860-a3b8hyyr	4596	5	study	study	NN
cord-006860-a3b8hyyr	4596	6	was	be	VBD
cord-006860-a3b8hyyr	4596	7	the	the	DT
cord-006860-a3b8hyyr	4596	8	evaluation	evaluation	NN
cord-006860-a3b8hyyr	4596	9	of	of	IN
cord-006860-a3b8hyyr	4596	10	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	4596	11	approach	approach	NN
cord-006860-a3b8hyyr	4596	12	to	to	IN
cord-006860-a3b8hyyr	4596	13	vWd	vWd	NNS
cord-006860-a3b8hyyr	4596	14	in	in	IN
cord-006860-a3b8hyyr	4596	15	childhood	childhood	NN
cord-006860-a3b8hyyr	4596	16	and	and	CC
cord-006860-a3b8hyyr	4596	17	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	4596	18	reliability	reliability	NN
cord-006860-a3b8hyyr	4596	19	of	of	IN
cord-006860-a3b8hyyr	4596	20	all	all	DT
cord-006860-a3b8hyyr	4596	21	available	available	JJ
cord-006860-a3b8hyyr	4596	22	laboratory	laboratory	NN
cord-006860-a3b8hyyr	4596	23	tests	test	NNS
cord-006860-a3b8hyyr	4596	24	.	.	.
cord-006860-a3b8hyyr	4597	1	All	all	DT
cord-006860-a3b8hyyr	4597	2	previously	previously	RB
cord-006860-a3b8hyyr	4597	3	mentioned	mention	VBD
cord-006860-a3b8hyyr	4597	4	laboratory	laboratory	NN
cord-006860-a3b8hyyr	4597	5	tests	test	NNS
cord-006860-a3b8hyyr	4597	6	have	have	VBP
cord-006860-a3b8hyyr	4597	7	been	be	VBN
cord-006860-a3b8hyyr	4597	8	done	do	VBN
cord-006860-a3b8hyyr	4597	9	on	on	IN
cord-006860-a3b8hyyr	4597	10	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4597	11	own	own	JJ
cord-006860-a3b8hyyr	4597	12	material	material	NN
cord-006860-a3b8hyyr	4597	13	(	(	-LRB-
cord-006860-a3b8hyyr	4597	14	51	51	CD
cord-006860-a3b8hyyr	4597	15	child	child	NN
cord-006860-a3b8hyyr	4597	16	who	who	WP
cord-006860-a3b8hyyr	4597	17	satisfied	satisfy	VBD
cord-006860-a3b8hyyr	4597	18	all	all	DT
cord-006860-a3b8hyyr	4597	19	criteria	criterion	NNS
cord-006860-a3b8hyyr	4597	20	for	for	IN
cord-006860-a3b8hyyr	4597	21	vWd	vWd	NNS
cord-006860-a3b8hyyr	4597	22	,	,	,
cord-006860-a3b8hyyr	4597	23	23	23	CD
cord-006860-a3b8hyyr	4597	24	boys	boy	NNS
cord-006860-a3b8hyyr	4597	25	and	and	CC
cord-006860-a3b8hyyr	4597	26	28	28	CD
cord-006860-a3b8hyyr	4597	27	girls	girl	NNS
cord-006860-a3b8hyyr	4597	28	,	,	,
cord-006860-a3b8hyyr	4597	29	1	1	CD
cord-006860-a3b8hyyr	4597	30	-	-	SYM
cord-006860-a3b8hyyr	4597	31	9	9	CD
cord-006860-a3b8hyyr	4597	32	years	year	NNS
cord-006860-a3b8hyyr	4597	33	old	old	JJ
cord-006860-a3b8hyyr	4597	34	)	)	-RRB-
cord-006860-a3b8hyyr	4597	35	except	except	IN
cord-006860-a3b8hyyr	4597	36	mulfimer	mulfimer	NNP
cord-006860-a3b8hyyr	4597	37	analysis	analysis	NN
cord-006860-a3b8hyyr	4597	38	which	which	WDT
cord-006860-a3b8hyyr	4597	39	was	be	VBD
cord-006860-a3b8hyyr	4597	40	unavailable	unavailable	JJ
cord-006860-a3b8hyyr	4597	41	in	in	IN
cord-006860-a3b8hyyr	4597	42	some	some	DT
cord-006860-a3b8hyyr	4597	43	cases	case	NNS
cord-006860-a3b8hyyr	4597	44	.	.	.
cord-006860-a3b8hyyr	4598	1	Majority	majority	NN
cord-006860-a3b8hyyr	4598	2	of	of	IN
cord-006860-a3b8hyyr	4598	3	laboratory	laboratory	NN
cord-006860-a3b8hyyr	4598	4	tests	test	NNS
cord-006860-a3b8hyyr	4598	5	proved	prove	VBN
cord-006860-a3b8hyyr	4598	6	to	to	TO
cord-006860-a3b8hyyr	4598	7	be	be	VB
cord-006860-a3b8hyyr	4598	8	highly	highly	RB
cord-006860-a3b8hyyr	4598	9	specific	specific	JJ
cord-006860-a3b8hyyr	4598	10	and	and	CC
cord-006860-a3b8hyyr	4598	11	necessary	necessary	JJ
cord-006860-a3b8hyyr	4598	12	for	for	IN
cord-006860-a3b8hyyr	4598	13	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	4598	14	.	.	.
cord-006860-a3b8hyyr	4599	1	However	however	RB
cord-006860-a3b8hyyr	4599	2	,	,	,
cord-006860-a3b8hyyr	4599	3	the	the	DT
cord-006860-a3b8hyyr	4599	4	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	4599	5	reliability	reliability	NN
cord-006860-a3b8hyyr	4599	6	of	of	IN
cord-006860-a3b8hyyr	4599	7	FVIII	FVIII	NNP
cord-006860-a3b8hyyr	4599	8	:	:	:
cord-006860-a3b8hyyr	4599	9	c	c	NN
cord-006860-a3b8hyyr	4599	10	and	and	CC
cord-006860-a3b8hyyr	4599	11	adhesion	adhesion	NN
cord-006860-a3b8hyyr	4599	12	of	of	IN
cord-006860-a3b8hyyr	4599	13	platelets	platelet	NNS
cord-006860-a3b8hyyr	4599	14	is	be	VBZ
cord-006860-a3b8hyyr	4599	15	much	much	RB
cord-006860-a3b8hyyr	4599	16	lower	low	JJR
cord-006860-a3b8hyyr	4599	17	in	in	IN
cord-006860-a3b8hyyr	4599	18	mild	mild	JJ
cord-006860-a3b8hyyr	4599	19	cases	case	NNS
cord-006860-a3b8hyyr	4599	20	in	in	IN
cord-006860-a3b8hyyr	4599	21	comparison	comparison	NN
cord-006860-a3b8hyyr	4599	22	to	to	IN
cord-006860-a3b8hyyr	4599	23	total	total	JJ
cord-006860-a3b8hyyr	4599	24	sample	sample	NN
cord-006860-a3b8hyyr	4599	25	,	,	,
cord-006860-a3b8hyyr	4599	26	while	while	IN
cord-006860-a3b8hyyr	4599	27	PTT	PTT	NNP
cord-006860-a3b8hyyr	4599	28	is	be	VBZ
cord-006860-a3b8hyyr	4599	29	an	an	DT
cord-006860-a3b8hyyr	4599	30	unvaiied	unvaiied	JJ
cord-006860-a3b8hyyr	4599	31	test	test	NN
cord-006860-a3b8hyyr	4599	32	.	.	.
cord-006860-a3b8hyyr	4600	1	The	the	DT
cord-006860-a3b8hyyr	4600	2	most	most	RBS
cord-006860-a3b8hyyr	4600	3	specific	specific	JJ
cord-006860-a3b8hyyr	4600	4	screening	screening	NN
cord-006860-a3b8hyyr	4600	5	test	test	NN
cord-006860-a3b8hyyr	4600	6	for	for	IN
cord-006860-a3b8hyyr	4601	1	vWd	vWd	NNP
cord-006860-a3b8hyyr	4601	2	is	be	VBZ
cord-006860-a3b8hyyr	4602	1	vWF	vwf	IN
cord-006860-a3b8hyyr	4602	2	which	which	WDT
cord-006860-a3b8hyyr	4602	3	diagnostic	diagnostic	JJ
cord-006860-a3b8hyyr	4602	4	reliability	reliability	NN
cord-006860-a3b8hyyr	4602	5	is	be	VBZ
cord-006860-a3b8hyyr	4602	6	almost	almost	RB
cord-006860-a3b8hyyr	4602	7	1,00	1,00	CD
cord-006860-a3b8hyyr	4602	8	.	.	.
cord-006860-a3b8hyyr	4603	1	The	the	DT
cord-006860-a3b8hyyr	4603	2	optimal	optimal	JJ
cord-006860-a3b8hyyr	4603	3	strategy	strategy	NN
cord-006860-a3b8hyyr	4603	4	to	to	TO
cord-006860-a3b8hyyr	4603	5	establish	establish	VB
cord-006860-a3b8hyyr	4603	6	general	general	JJ
cord-006860-a3b8hyyr	4603	7	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	4603	8	of	of	IN
cord-006860-a3b8hyyr	4603	9	mild	mild	JJ
cord-006860-a3b8hyyr	4603	10	forms	form	NNS
cord-006860-a3b8hyyr	4603	11	ofvWd	ofvWd	``
cord-006860-a3b8hyyr	4603	12	is	be	VBZ
cord-006860-a3b8hyyr	4603	13	use	use	NN
cord-006860-a3b8hyyr	4603	14	of	of	IN
cord-006860-a3b8hyyr	4603	15	vWF	vwf	NN
cord-006860-a3b8hyyr	4603	16	and	and	CC
cord-006860-a3b8hyyr	4603	17	vWF	vwf	NN
cord-006860-a3b8hyyr	4603	18	:	:	:
cord-006860-a3b8hyyr	4604	1	Ag	Ag	NNP
cord-006860-a3b8hyyr	4604	2	plus	plus	CC
cord-006860-a3b8hyyr	4604	3	RIPA	RIPA	NNP
cord-006860-a3b8hyyr	4604	4	if	if	IN
cord-006860-a3b8hyyr	4604	5	necessary	necessary	JJ
cord-006860-a3b8hyyr	4604	6	and	and	CC
cord-006860-a3b8hyyr	4604	7	multimer	multimer	VBD
cord-006860-a3b8hyyr	4604	8	analysis	analysis	NN
cord-006860-a3b8hyyr	4604	9	to	to	TO
cord-006860-a3b8hyyr	4604	10	classify	classify	VB
cord-006860-a3b8hyyr	4604	11	variant	variant	JJ
cord-006860-a3b8hyyr	4604	12	types	type	NNS
cord-006860-a3b8hyyr	4604	13	.	.	.
cord-006860-a3b8hyyr	4605	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4605	2	report	report	VBP
cord-006860-a3b8hyyr	4605	3	on	on	IN
cord-006860-a3b8hyyr	4605	4	a	a	DT
cord-006860-a3b8hyyr	4605	5	new	new	JJ
cord-006860-a3b8hyyr	4605	6	multimeric	multimeric	JJ
cord-006860-a3b8hyyr	4605	7	structural	structural	JJ
cord-006860-a3b8hyyr	4605	8	defect	defect	NN
cord-006860-a3b8hyyr	4605	9	of	of	IN
cord-006860-a3b8hyyr	4605	10	vWF	vwf	NN
cord-006860-a3b8hyyr	4605	11	detected	detect	VBN
cord-006860-a3b8hyyr	4605	12	in	in	IN
cord-006860-a3b8hyyr	4605	13	a	a	DT
cord-006860-a3b8hyyr	4605	14	German	german	JJ
cord-006860-a3b8hyyr	4605	15	family	family	NN
cord-006860-a3b8hyyr	4605	16	(	(	-LRB-
cord-006860-a3b8hyyr	4605	17	two	two	CD
cord-006860-a3b8hyyr	4605	18	sisters	sister	NNS
cord-006860-a3b8hyyr	4605	19	and	and	CC
cord-006860-a3b8hyyr	4605	20	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4605	21	three	three	CD
cord-006860-a3b8hyyr	4605	22	children	child	NNS
cord-006860-a3b8hyyr	4605	23	)	)	-RRB-
cord-006860-a3b8hyyr	4605	24	:	:	:
cord-006860-a3b8hyyr	4605	25	All	all	DT
cord-006860-a3b8hyyr	4605	26	members	member	NNS
cord-006860-a3b8hyyr	4605	27	of	of	IN
cord-006860-a3b8hyyr	4605	28	the	the	DT
cord-006860-a3b8hyyr	4605	29	family	family	NN
cord-006860-a3b8hyyr	4605	30	who	who	WP
cord-006860-a3b8hyyr	4605	31	presented	present	VBD
cord-006860-a3b8hyyr	4605	32	to	to	IN
cord-006860-a3b8hyyr	4605	33	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4605	34	outpatient	outpatient	NN
cord-006860-a3b8hyyr	4605	35	clinic	clinic	NN
cord-006860-a3b8hyyr	4605	36	had	have	VBD
cord-006860-a3b8hyyr	4605	37	an	an	DT
cord-006860-a3b8hyyr	4605	38	increased	increase	VBN
cord-006860-a3b8hyyr	4605	39	spontanous	spontanous	JJ
cord-006860-a3b8hyyr	4605	40	bleeding	bleeding	NN
cord-006860-a3b8hyyr	4605	41	tendency	tendency	NN
cord-006860-a3b8hyyr	4605	42	(	(	-LRB-
cord-006860-a3b8hyyr	4605	43	moderate	moderate	JJ
cord-006860-a3b8hyyr	4605	44	or	or	CC
cord-006860-a3b8hyyr	4605	45	strong	strong	JJ
cord-006860-a3b8hyyr	4605	46	hematoma	hematoma	NN
cord-006860-a3b8hyyr	4605	47	,	,	,
cord-006860-a3b8hyyr	4605	48	epistaxis	epistaxis	NN
cord-006860-a3b8hyyr	4605	49	,	,	,
cord-006860-a3b8hyyr	4605	50	menorrhagia	menorrhagia	NN
cord-006860-a3b8hyyr	4605	51	)	)	-RRB-
cord-006860-a3b8hyyr	4605	52	.	.	.
cord-006860-a3b8hyyr	4606	1	Prolonged	prolonged	JJ
cord-006860-a3b8hyyr	4606	2	bleeding	bleeding	NN
cord-006860-a3b8hyyr	4606	3	could	could	MD
cord-006860-a3b8hyyr	4606	4	be	be	VB
cord-006860-a3b8hyyr	4606	5	observed	observe	VBN
cord-006860-a3b8hyyr	4606	6	after	after	IN
cord-006860-a3b8hyyr	4606	7	surgical	surgical	JJ
cord-006860-a3b8hyyr	4606	8	procedures	procedure	NNS
cord-006860-a3b8hyyr	4606	9	(	(	-LRB-
cord-006860-a3b8hyyr	4606	10	adenotomia	adenotomia	NNP
cord-006860-a3b8hyyr	4606	11	,	,	,
cord-006860-a3b8hyyr	4606	12	tooth	tooth	NN
cord-006860-a3b8hyyr	4606	13	extraction	extraction	NN
cord-006860-a3b8hyyr	4606	14	)	)	-RRB-
cord-006860-a3b8hyyr	4606	15	and	and	CC
cord-006860-a3b8hyyr	4606	16	after	after	IN
cord-006860-a3b8hyyr	4606	17	trauma	trauma	NN
cord-006860-a3b8hyyr	4606	18	(	(	-LRB-
cord-006860-a3b8hyyr	4606	19	laceration	laceration	NN
cord-006860-a3b8hyyr	4606	20	)	)	-RRB-
cord-006860-a3b8hyyr	4606	21	.	.	.
cord-006860-a3b8hyyr	4607	1	Wound	wound	JJ
cord-006860-a3b8hyyr	4607	2	heeling	heeling	NN
cord-006860-a3b8hyyr	4607	3	was	be	VBD
cord-006860-a3b8hyyr	4607	4	impaired	impair	VBN
cord-006860-a3b8hyyr	4607	5	in	in	IN
cord-006860-a3b8hyyr	4607	6	two	two	CD
cord-006860-a3b8hyyr	4607	7	cases	case	NNS
cord-006860-a3b8hyyr	4607	8	.	.	.
cord-006860-a3b8hyyr	4608	1	Clotting	clotting	NN
cord-006860-a3b8hyyr	4608	2	assays	assay	NNS
cord-006860-a3b8hyyr	4608	3	showed	show	VBD
cord-006860-a3b8hyyr	4608	4	slightly	slightly	RB
cord-006860-a3b8hyyr	4608	5	prolonged	prolong	VBN
cord-006860-a3b8hyyr	4608	6	aPTI	apti	NN
cord-006860-a3b8hyyr	4608	7	"	"	''
cord-006860-a3b8hyyr	4608	8	and	and	CC
cord-006860-a3b8hyyr	4608	9	a	a	DT
cord-006860-a3b8hyyr	4608	10	mild	mild	JJ
cord-006860-a3b8hyyr	4608	11	decrease	decrease	NN
cord-006860-a3b8hyyr	4608	12	of	of	IN
cord-006860-a3b8hyyr	4608	13	F	F	NNP
cord-006860-a3b8hyyr	4608	14	VIII	VIII	NNP
cord-006860-a3b8hyyr	4608	15	:	:	:
cord-006860-a3b8hyyr	4608	16	C	C	NNP
cord-006860-a3b8hyyr	4608	17	,	,	,
cord-006860-a3b8hyyr	4608	18	vWF	vwf	NN
cord-006860-a3b8hyyr	4608	19	:	:	:
cord-006860-a3b8hyyr	4608	20	AG	AG	NNP
cord-006860-a3b8hyyr	4608	21	and	and	CC
cord-006860-a3b8hyyr	4608	22	vWF	vwf	NN
cord-006860-a3b8hyyr	4608	23	:	:	:
cord-006860-a3b8hyyr	4608	24	RCof	rcof	NN
cord-006860-a3b8hyyr	4608	25	levels	level	NNS
cord-006860-a3b8hyyr	4608	26	.	.	.
cord-006860-a3b8hyyr	4609	1	Collagen	collagen	NN
cord-006860-a3b8hyyr	4609	2	binding	binding	NN
cord-006860-a3b8hyyr	4609	3	activity	activity	NN
cord-006860-a3b8hyyr	4609	4	was	be	VBD
cord-006860-a3b8hyyr	4609	5	within	within	IN
cord-006860-a3b8hyyr	4609	6	normal	normal	JJ
cord-006860-a3b8hyyr	4609	7	ranges	range	NNS
cord-006860-a3b8hyyr	4609	8	.	.	.
cord-006860-a3b8hyyr	4610	1	Bleeding	bleed	VBG
cord-006860-a3b8hyyr	4610	2	time	time	NN
cord-006860-a3b8hyyr	4610	3	(	(	-LRB-
cord-006860-a3b8hyyr	4610	4	Simplate	Simplate	NNP
cord-006860-a3b8hyyr	4610	5	I	i	NN
cord-006860-a3b8hyyr	4610	6	)	)	-RRB-
cord-006860-a3b8hyyr	4610	7	was	be	VBD
cord-006860-a3b8hyyr	4610	8	slightly	slightly	RB
cord-006860-a3b8hyyr	4610	9	prolonged	prolong	VBN
cord-006860-a3b8hyyr	4610	10	.	.	.
cord-006860-a3b8hyyr	4611	1	The	the	DT
cord-006860-a3b8hyyr	4611	2	analysis	analysis	NN
cord-006860-a3b8hyyr	4611	3	of	of	IN
cord-006860-a3b8hyyr	4611	4	the	the	DT
cord-006860-a3b8hyyr	4611	5	multimeric	multimeric	JJ
cord-006860-a3b8hyyr	4611	6	structure	structure	NN
cord-006860-a3b8hyyr	4611	7	in	in	IN
cord-006860-a3b8hyyr	4611	8	plasma	plasma	NN
cord-006860-a3b8hyyr	4611	9	showed	show	VBD
cord-006860-a3b8hyyr	4611	10	quantitative	quantitative	JJ
cord-006860-a3b8hyyr	4611	11	and	and	CC
cord-006860-a3b8hyyr	4611	12	qualitative	qualitative	JJ
cord-006860-a3b8hyyr	4611	13	abnormalities	abnormality	NNS
cord-006860-a3b8hyyr	4611	14	:	:	:
cord-006860-a3b8hyyr	4611	15	All	all	DT
cord-006860-a3b8hyyr	4611	16	multimers	multimer	NNS
cord-006860-a3b8hyyr	4611	17	were	be	VBD
cord-006860-a3b8hyyr	4611	18	detectable	detectable	JJ
cord-006860-a3b8hyyr	4611	19	;	;	:
cord-006860-a3b8hyyr	4611	20	the	the	DT
cord-006860-a3b8hyyr	4611	21	structure	structure	NN
cord-006860-a3b8hyyr	4611	22	of	of	IN
cord-006860-a3b8hyyr	4611	23	vWF	vWF	NNP
cord-006860-a3b8hyyr	4611	24	was	be	VBD
cord-006860-a3b8hyyr	4611	25	reproducably	reproducably	RB
cord-006860-a3b8hyyr	4611	26	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	4611	27	in	in	IN
cord-006860-a3b8hyyr	4611	28	all	all	DT
cord-006860-a3b8hyyr	4611	29	family	family	NN
cord-006860-a3b8hyyr	4611	30	members	member	NNS
cord-006860-a3b8hyyr	4611	31	so	so	IN
cord-006860-a3b8hyyr	4611	32	that	that	IN
cord-006860-a3b8hyyr	4611	33	the	the	DT
cord-006860-a3b8hyyr	4611	34	defect	defect	NN
cord-006860-a3b8hyyr	4611	35	must	must	MD
cord-006860-a3b8hyyr	4611	36	be	be	VB
cord-006860-a3b8hyyr	4611	37	caused	cause	VBN
cord-006860-a3b8hyyr	4611	38	genetically	genetically	RB
cord-006860-a3b8hyyr	4611	39	.	.	.
cord-006860-a3b8hyyr	4612	1	The	the	DT
cord-006860-a3b8hyyr	4612	2	thmmbocytic	thmmbocytic	JJ
cord-006860-a3b8hyyr	4612	3	vWF	vwf	TO
cord-006860-a3b8hyyr	4612	4	showed	show	VBD
cord-006860-a3b8hyyr	4612	5	neither	neither	CC
cord-006860-a3b8hyyr	4612	6	qualitative	qualitative	JJ
cord-006860-a3b8hyyr	4612	7	nor	nor	CC
cord-006860-a3b8hyyr	4612	8	quantitative	quantitative	JJ
cord-006860-a3b8hyyr	4612	9	alterations	alteration	NNS
cord-006860-a3b8hyyr	4612	10	.	.	.
cord-006860-a3b8hyyr	4613	1	Minirin@	Minirin@	NNP
cord-006860-a3b8hyyr	4613	2	(	(	-LRB-
cord-006860-a3b8hyyr	4613	3	DDAVP	DDAVP	NNP
cord-006860-a3b8hyyr	4613	4	)	)	-RRB-
cord-006860-a3b8hyyr	4613	5	was	be	VBD
cord-006860-a3b8hyyr	4613	6	administered	administer	VBN
cord-006860-a3b8hyyr	4613	7	as	as	IN
cord-006860-a3b8hyyr	4613	8	a	a	DT
cord-006860-a3b8hyyr	4613	9	test	test	NN
cord-006860-a3b8hyyr	4613	10	dose	dose	NN
cord-006860-a3b8hyyr	4613	11	of	of	IN
cord-006860-a3b8hyyr	4613	12	0,3	0,3	CD
cord-006860-a3b8hyyr	4614	1	~tg	~tg	NNP
cord-006860-a3b8hyyr	4615	1	/kg	/kg	NFP
cord-006860-a3b8hyyr	4615	2	BW	BW	NNP
cord-006860-a3b8hyyr	4615	3	in	in	IN
cord-006860-a3b8hyyr	4615	4	100	100	CD
cord-006860-a3b8hyyr	4615	5	ml	ml	NN
cord-006860-a3b8hyyr	4615	6	0,9	0,9	CD
cord-006860-a3b8hyyr	4615	7	%	%	NN
cord-006860-a3b8hyyr	4615	8	NaCL	nacl	NN
cord-006860-a3b8hyyr	4615	9	-	-	HYPH
cord-006860-a3b8hyyr	4615	10	solution	solution	NN
cord-006860-a3b8hyyr	4615	11	i.v	i.v	NNP
cord-006860-a3b8hyyr	4615	12	.	.	.
cord-006860-a3b8hyyr	4616	1	to	to	TO
cord-006860-a3b8hyyr	4616	2	evaluate	evaluate	VB
cord-006860-a3b8hyyr	4616	3	efficacy	efficacy	NN
cord-006860-a3b8hyyr	4616	4	and	and	CC
cord-006860-a3b8hyyr	4616	5	tolerance	tolerance	NN
cord-006860-a3b8hyyr	4616	6	:	:	:
cord-006860-a3b8hyyr	4616	7	Clotting	clotting	NN
cord-006860-a3b8hyyr	4616	8	assays	assay	NNS
cord-006860-a3b8hyyr	4616	9	showed	show	VBD
cord-006860-a3b8hyyr	4616	10	normalization	normalization	NN
cord-006860-a3b8hyyr	4616	11	of	of	IN
cord-006860-a3b8hyyr	4616	12	a_VrT	a_vrt	CD
cord-006860-a3b8hyyr	4616	13	,	,	,
cord-006860-a3b8hyyr	4616	14	F	F	NNP
cord-006860-a3b8hyyr	4616	15	VIII	VIII	NNP
cord-006860-a3b8hyyr	4616	16	:	:	:
cord-006860-a3b8hyyr	4616	17	C	C	NNP
cord-006860-a3b8hyyr	4616	18	,	,	,
cord-006860-a3b8hyyr	4616	19	vWF	vwf	NN
cord-006860-a3b8hyyr	4616	20	:	:	:
cord-006860-a3b8hyyr	4616	21	AG	AG	NNP
cord-006860-a3b8hyyr	4616	22	,	,	,
cord-006860-a3b8hyyr	4616	23	vWF	vwf	NN
cord-006860-a3b8hyyr	4616	24	:	:	:
cord-006860-a3b8hyyr	4616	25	RCof	rcof	NN
cord-006860-a3b8hyyr	4616	26	in	in	IN
cord-006860-a3b8hyyr	4616	27	plasma	plasma	NN
cord-006860-a3b8hyyr	4616	28	and	and	CC
cord-006860-a3b8hyyr	4616	29	shortening	shortening	NN
cord-006860-a3b8hyyr	4616	30	of	of	IN
cord-006860-a3b8hyyr	4616	31	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4616	32	time	time	NN
cord-006860-a3b8hyyr	4616	33	in	in	IN
cord-006860-a3b8hyyr	4616	34	three	three	CD
cord-006860-a3b8hyyr	4616	35	cases	case	NNS
cord-006860-a3b8hyyr	4616	36	.	.	.
cord-006860-a3b8hyyr	4617	1	An	an	DT
cord-006860-a3b8hyyr	4617	2	insufficient	insufficient	JJ
cord-006860-a3b8hyyr	4617	3	rise	rise	NN
cord-006860-a3b8hyyr	4617	4	of	of	IN
cord-006860-a3b8hyyr	4617	5	vWF	vwf	NN
cord-006860-a3b8hyyr	4617	6	:	:	:
cord-006860-a3b8hyyr	4618	1	AG	AG	NNP
cord-006860-a3b8hyyr	4618	2	and	and	CC
cord-006860-a3b8hyyr	4618	3	vWF	vwf	NN
cord-006860-a3b8hyyr	4618	4	:	:	:
cord-006860-a3b8hyyr	4618	5	RCof	rcof	NN
cord-006860-a3b8hyyr	4618	6	levels	level	NNS
cord-006860-a3b8hyyr	4618	7	could	could	MD
cord-006860-a3b8hyyr	4618	8	be	be	VB
cord-006860-a3b8hyyr	4618	9	observed	observe	VBN
cord-006860-a3b8hyyr	4618	10	in	in	IN
cord-006860-a3b8hyyr	4618	11	one	one	CD
cord-006860-a3b8hyyr	4618	12	case	case	NN
cord-006860-a3b8hyyr	4618	13	.	.	.
cord-006860-a3b8hyyr	4619	1	One	one	CD
cord-006860-a3b8hyyr	4619	2	patient	patient	NN
cord-006860-a3b8hyyr	4619	3	had	have	VBD
cord-006860-a3b8hyyr	4619	4	no	no	DT
cord-006860-a3b8hyyr	4619	5	rise	rise	NN
cord-006860-a3b8hyyr	4619	6	of	of	IN
cord-006860-a3b8hyyr	4619	7	F	F	NNP
cord-006860-a3b8hyyr	4619	8	Vm	Vm	NNP
cord-006860-a3b8hyyr	4619	9	:	:	:
cord-006860-a3b8hyyr	4620	1	C	C	NNP
cord-006860-a3b8hyyr	4620	2	but	but	CC
cord-006860-a3b8hyyr	4620	3	a	a	DT
cord-006860-a3b8hyyr	4620	4	corrected	correct	VBN
cord-006860-a3b8hyyr	4620	5	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4620	6	time	time	NN
cord-006860-a3b8hyyr	4620	7	.	.	.
cord-006860-a3b8hyyr	4621	1	Multimeric	multimeric	JJ
cord-006860-a3b8hyyr	4621	2	analysis	analysis	NN
cord-006860-a3b8hyyr	4621	3	showed	show	VBD
cord-006860-a3b8hyyr	4621	4	no	no	DT
cord-006860-a3b8hyyr	4621	5	structural	structural	JJ
cord-006860-a3b8hyyr	4621	6	change	change	NN
cord-006860-a3b8hyyr	4621	7	.	.	.
cord-006860-a3b8hyyr	4622	1	The	the	DT
cord-006860-a3b8hyyr	4622	2	administration	administration	NN
cord-006860-a3b8hyyr	4622	3	of	of	IN
cord-006860-a3b8hyyr	4622	4	DDAVP	DDAVP	NNP
cord-006860-a3b8hyyr	4622	5	was	be	VBD
cord-006860-a3b8hyyr	4622	6	well	well	RB
cord-006860-a3b8hyyr	4622	7	tolcrated	tolcrate	VBN
cord-006860-a3b8hyyr	4622	8	in	in	IN
cord-006860-a3b8hyyr	4622	9	all	all	DT
cord-006860-a3b8hyyr	4622	10	cases	case	NNS
cord-006860-a3b8hyyr	4622	11	.	.	.
cord-006860-a3b8hyyr	4623	1	The	the	DT
cord-006860-a3b8hyyr	4623	2	existance	existance	NN
cord-006860-a3b8hyyr	4623	3	of	of	IN
cord-006860-a3b8hyyr	4623	4	all	all	DT
cord-006860-a3b8hyyr	4623	5	multimers	multimer	NNS
cord-006860-a3b8hyyr	4623	6	in	in	IN
cord-006860-a3b8hyyr	4623	7	plasma	plasma	NN
cord-006860-a3b8hyyr	4623	8	and	and	CC
cord-006860-a3b8hyyr	4623	9	the	the	DT
cord-006860-a3b8hyyr	4623	10	normal	normal	JJ
cord-006860-a3b8hyyr	4623	11	collagen	collagen	NN
cord-006860-a3b8hyyr	4623	12	binding	bind	VBG
cord-006860-a3b8hyyr	4623	13	activity	activity	NN
cord-006860-a3b8hyyr	4623	14	suggest	suggest	VBP
cord-006860-a3b8hyyr	4623	15	that	that	IN
cord-006860-a3b8hyyr	4623	16	the	the	DT
cord-006860-a3b8hyyr	4623	17	structural	structural	JJ
cord-006860-a3b8hyyr	4623	18	abnormalities	abnormality	NNS
cord-006860-a3b8hyyr	4623	19	of	of	IN
cord-006860-a3b8hyyr	4623	20	vWF	vwf	NN
cord-006860-a3b8hyyr	4623	21	in	in	IN
cord-006860-a3b8hyyr	4623	22	this	this	DT
cord-006860-a3b8hyyr	4623	23	family	family	NN
cord-006860-a3b8hyyr	4623	24	does	do	VBZ
cord-006860-a3b8hyyr	4623	25	not	not	RB
cord-006860-a3b8hyyr	4623	26	cause	cause	VB
cord-006860-a3b8hyyr	4623	27	functional	functional	JJ
cord-006860-a3b8hyyr	4623	28	defects	defect	NNS
cord-006860-a3b8hyyr	4623	29	so	so	IN
cord-006860-a3b8hyyr	4623	30	that	that	IN
cord-006860-a3b8hyyr	4623	31	the	the	DT
cord-006860-a3b8hyyr	4623	32	defect	defect	NN
cord-006860-a3b8hyyr	4623	33	could	could	MD
cord-006860-a3b8hyyr	4623	34	be	be	VB
cord-006860-a3b8hyyr	4623	35	classified	classify	VBN
cord-006860-a3b8hyyr	4623	36	as	as	IN
cord-006860-a3b8hyyr	4623	37	a	a	DT
cord-006860-a3b8hyyr	4623	38	type	type	NN
cord-006860-a3b8hyyr	4623	39	I	-PRON-	PRP
cord-006860-a3b8hyyr	4623	40	vWD	vWD	VBD
cord-006860-a3b8hyyr	4623	41	.	.	.
cord-006860-a3b8hyyr	4624	1	The	the	DT
cord-006860-a3b8hyyr	4624	2	response	response	NN
cord-006860-a3b8hyyr	4624	3	to	to	IN
cord-006860-a3b8hyyr	4624	4	DDAVP	DDAVP	NNP
cord-006860-a3b8hyyr	4624	5	was	be	VBD
cord-006860-a3b8hyyr	4624	6	only	only	RB
cord-006860-a3b8hyyr	4624	7	partially	partially	RB
cord-006860-a3b8hyyr	4624	8	effective	effective	JJ
cord-006860-a3b8hyyr	4624	9	.	.	.
cord-006860-a3b8hyyr	4625	1	Mild	mild	JJ
cord-006860-a3b8hyyr	4625	2	von	von	NNP
cord-006860-a3b8hyyr	4625	3	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	4625	4	disease	disease	NN
cord-006860-a3b8hyyr	4625	5	(	(	-LRB-
cord-006860-a3b8hyyr	4625	6	vWd	vWd	NNS
cord-006860-a3b8hyyr	4625	7	)	)	-RRB-
cord-006860-a3b8hyyr	4625	8	is	be	VBZ
cord-006860-a3b8hyyr	4625	9	far	far	RB
cord-006860-a3b8hyyr	4625	10	the	the	DT
cord-006860-a3b8hyyr	4625	11	most	most	RBS
cord-006860-a3b8hyyr	4625	12	frequent	frequent	JJ
cord-006860-a3b8hyyr	4625	13	congenital	congenital	JJ
cord-006860-a3b8hyyr	4625	14	bleeding	bleeding	NN
cord-006860-a3b8hyyr	4625	15	tendency	tendency	NN
cord-006860-a3b8hyyr	4625	16	.	.	.
cord-006860-a3b8hyyr	4626	1	Its	-PRON-	PRP$
cord-006860-a3b8hyyr	4626	2	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	4626	3	is	be	VBZ
cord-006860-a3b8hyyr	4626	4	very	very	RB
cord-006860-a3b8hyyr	4626	5	helpful	helpful	JJ
cord-006860-a3b8hyyr	4626	6	in	in	IN
cord-006860-a3b8hyyr	4626	7	pre	pre	JJ
cord-006860-a3b8hyyr	4626	8	-	-	JJ
cord-006860-a3b8hyyr	4626	9	operative	operative	JJ
cord-006860-a3b8hyyr	4626	10	check	check	NN
cord-006860-a3b8hyyr	4626	11	-	-	HYPH
cord-006860-a3b8hyyr	4626	12	up	up	NN
cord-006860-a3b8hyyr	4626	13	in	in	IN
cord-006860-a3b8hyyr	4626	14	order	order	NN
cord-006860-a3b8hyyr	4626	15	to	to	TO
cord-006860-a3b8hyyr	4626	16	avoid	avoid	VB
cord-006860-a3b8hyyr	4626	17	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4626	18	complications	complication	NNS
cord-006860-a3b8hyyr	4626	19	during	during	IN
cord-006860-a3b8hyyr	4626	20	surgery	surgery	NN
cord-006860-a3b8hyyr	4626	21	.	.	.
cord-006860-a3b8hyyr	4627	1	Following	follow	VBG
cord-006860-a3b8hyyr	4627	2	post	post	JJ
cord-006860-a3b8hyyr	4627	3	-	-	JJ
cord-006860-a3b8hyyr	4627	4	operative	operative	JJ
cord-006860-a3b8hyyr	4627	5	periods	period	NNS
cord-006860-a3b8hyyr	4627	6	or	or	CC
cord-006860-a3b8hyyr	4627	7	monitoring	monitor	VBG
cord-006860-a3b8hyyr	4627	8	the	the	DT
cord-006860-a3b8hyyr	4627	9	management	management	NN
cord-006860-a3b8hyyr	4627	10	of	of	IN
cord-006860-a3b8hyyr	4627	11	haemorrhagic	haemorrhagic	JJ
cord-006860-a3b8hyyr	4627	12	episodes	episode	NNS
cord-006860-a3b8hyyr	4627	13	in	in	IN
cord-006860-a3b8hyyr	4627	14	vWd	vWd	NNS
cord-006860-a3b8hyyr	4627	15	patients	patient	NNS
cord-006860-a3b8hyyr	4627	16	is	be	VBZ
cord-006860-a3b8hyyr	4627	17	also	also	RB
cord-006860-a3b8hyyr	4627	18	strongly	strongly	RB
cord-006860-a3b8hyyr	4627	19	recommended	recommend	VBN
cord-006860-a3b8hyyr	4627	20	.	.	.
cord-006860-a3b8hyyr	4628	1	Current	current	JJ
cord-006860-a3b8hyyr	4628	2	methods	method	NNS
cord-006860-a3b8hyyr	4628	3	involve	involve	VBP
cord-006860-a3b8hyyr	4628	4	complex	complex	JJ
cord-006860-a3b8hyyr	4628	5	technologies	technology	NNS
cord-006860-a3b8hyyr	4628	6	,	,	,
cord-006860-a3b8hyyr	4628	7	are	be	VBP
cord-006860-a3b8hyyr	4628	8	time	time	NN
cord-006860-a3b8hyyr	4628	9	consuming	consume	VBG
cord-006860-a3b8hyyr	4628	10	and	and	CC
cord-006860-a3b8hyyr	4628	11	require	require	VB
cord-006860-a3b8hyyr	4628	12	large	large	JJ
cord-006860-a3b8hyyr	4628	13	series	series	NN
cord-006860-a3b8hyyr	4628	14	.	.	.
cord-006860-a3b8hyyr	4629	1	These	these	DT
cord-006860-a3b8hyyr	4629	2	assays	assay	NNS
cord-006860-a3b8hyyr	4629	3	lack	lack	VBP
cord-006860-a3b8hyyr	4629	4	the	the	DT
cord-006860-a3b8hyyr	4629	5	expected	expect	VBN
cord-006860-a3b8hyyr	4629	6	flexibility	flexibility	NN
cord-006860-a3b8hyyr	4629	7	for	for	IN
cord-006860-a3b8hyyr	4629	8	rapid	rapid	JJ
cord-006860-a3b8hyyr	4629	9	individual	individual	JJ
cord-006860-a3b8hyyr	4629	10	testing	testing	NN
cord-006860-a3b8hyyr	4629	11	in	in	IN
cord-006860-a3b8hyyr	4629	12	patients	patient	NNS
cord-006860-a3b8hyyr	4629	13	.	.	.
cord-006860-a3b8hyyr	4630	1	A	a	DT
cord-006860-a3b8hyyr	4630	2	new	new	JJ
cord-006860-a3b8hyyr	4630	3	and	and	CC
cord-006860-a3b8hyyr	4630	4	flexible	flexible	JJ
cord-006860-a3b8hyyr	4630	5	assay	assay	NN
cord-006860-a3b8hyyr	4630	6	which	which	WDT
cord-006860-a3b8hyyr	4630	7	works	work	VBZ
cord-006860-a3b8hyyr	4630	8	on	on	IN
cord-006860-a3b8hyyr	4630	9	the	the	DT
cord-006860-a3b8hyyr	4630	10	fully	fully	RB
cord-006860-a3b8hyyr	4630	11	automatic	automatic	JJ
cord-006860-a3b8hyyr	4630	12	walk	walk	NN
cord-006860-a3b8hyyr	4630	13	-	-	HYPH
cord-006860-a3b8hyyr	4630	14	away	away	RP
cord-006860-a3b8hyyr	4630	15	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4630	16	instrument	instrument	NN
cord-006860-a3b8hyyr	4630	17	,	,	,
cord-006860-a3b8hyyr	4630	18	STA	STA	NNP
cord-006860-a3b8hyyr	4630	19	,	,	,
cord-006860-a3b8hyyr	4630	20	has	have	VBZ
cord-006860-a3b8hyyr	4630	21	been	be	VBN
cord-006860-a3b8hyyr	4630	22	developed	develop	VBN
cord-006860-a3b8hyyr	4630	23	for	for	IN
cord-006860-a3b8hyyr	4630	24	these	these	DT
cord-006860-a3b8hyyr	4630	25	applications	application	NNS
cord-006860-a3b8hyyr	4630	26	(	(	-LRB-
cord-006860-a3b8hyyr	4630	27	Liatest	Liatest	NNP
cord-006860-a3b8hyyr	4630	28	vWF	vWF	NNP
cord-006860-a3b8hyyr	4630	29	)	)	-RRB-
cord-006860-a3b8hyyr	4630	30	.	.	.
cord-006860-a3b8hyyr	4631	1	The	the	DT
cord-006860-a3b8hyyr	4631	2	technology	technology	NN
cord-006860-a3b8hyyr	4631	3	is	be	VBZ
cord-006860-a3b8hyyr	4631	4	an	an	DT
cord-006860-a3b8hyyr	4631	5	immuno	immuno	JJ
cord-006860-a3b8hyyr	4631	6	-	-	JJ
cord-006860-a3b8hyyr	4631	7	turbidimetric	turbidimetric	JJ
cord-006860-a3b8hyyr	4631	8	method	method	NN
cord-006860-a3b8hyyr	4631	9	using	use	VBG
cord-006860-a3b8hyyr	4631	10	mierolatex	mierolatex	NNP
cord-006860-a3b8hyyr	4631	11	particles	particle	NNS
cord-006860-a3b8hyyr	4631	12	coated	coat	VBN
cord-006860-a3b8hyyr	4631	13	with	with	IN
cord-006860-a3b8hyyr	4631	14	rabbit	rabbit	NN
cord-006860-a3b8hyyr	4631	15	polyelonal	polyelonal	NNP
cord-006860-a3b8hyyr	4631	16	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4631	17	specific	specific	JJ
cord-006860-a3b8hyyr	4631	18	for	for	IN
cord-006860-a3b8hyyr	4631	19	vWF	vWF	NNP
cord-006860-a3b8hyyr	4631	20	.	.	.
cord-006860-a3b8hyyr	4632	1	The	the	DT
cord-006860-a3b8hyyr	4632	2	assay	assay	NN
cord-006860-a3b8hyyr	4632	3	has	have	VBZ
cord-006860-a3b8hyyr	4632	4	a	a	DT
cord-006860-a3b8hyyr	4632	5	dynamic	dynamic	JJ
cord-006860-a3b8hyyr	4632	6	range	range	NN
cord-006860-a3b8hyyr	4632	7	from	from	IN
cord-006860-a3b8hyyr	4632	8	2	2	CD
cord-006860-a3b8hyyr	4632	9	to	to	IN
cord-006860-a3b8hyyr	4632	10	420	420	CD
cord-006860-a3b8hyyr	4632	11	%	%	NN
cord-006860-a3b8hyyr	4632	12	yon	yon	NNP
cord-006860-a3b8hyyr	4632	13	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	4632	14	factor	factor	NN
cord-006860-a3b8hyyr	4632	15	(	(	-LRB-
cord-006860-a3b8hyyr	4632	16	vWF	vwf	NN
cord-006860-a3b8hyyr	4632	17	)	)	-RRB-
cord-006860-a3b8hyyr	4632	18	concentration	concentration	NN
cord-006860-a3b8hyyr	4632	19	,	,	,
cord-006860-a3b8hyyr	4632	20	it	-PRON-	PRP
cord-006860-a3b8hyyr	4632	21	works	work	VBZ
cord-006860-a3b8hyyr	4632	22	with	with	IN
cord-006860-a3b8hyyr	4632	23	a	a	DT
cord-006860-a3b8hyyr	4632	24	2	2	CD
cord-006860-a3b8hyyr	4632	25	fold	fold	NN
cord-006860-a3b8hyyr	4632	26	dilution	dilution	NN
cord-006860-a3b8hyyr	4632	27	of	of	IN
cord-006860-a3b8hyyr	4632	28	tested	test	VBN
cord-006860-a3b8hyyr	4632	29	plasma	plasma	NN
cord-006860-a3b8hyyr	4632	30	(	(	-LRB-
cord-006860-a3b8hyyr	4632	31	50	50	CD
cord-006860-a3b8hyyr	4632	32	td	td	NNP
cord-006860-a3b8hyyr	4632	33	)	)	-RRB-
cord-006860-a3b8hyyr	4632	34	and	and	CC
cord-006860-a3b8hyyr	4632	35	it	-PRON-	PRP
cord-006860-a3b8hyyr	4632	36	offers	offer	VBZ
cord-006860-a3b8hyyr	4632	37	a	a	DT
cord-006860-a3b8hyyr	4632	38	calibration	calibration	NN
cord-006860-a3b8hyyr	4632	39	established	establish	VBN
cord-006860-a3b8hyyr	4632	40	with	with	IN
cord-006860-a3b8hyyr	4632	41	the	the	DT
cord-006860-a3b8hyyr	4632	42	NIBSC	NIBSC	NNP
cord-006860-a3b8hyyr	4632	43	international	international	JJ
cord-006860-a3b8hyyr	4632	44	standard	standard	NN
cord-006860-a3b8hyyr	4632	45	.	.	.
cord-006860-a3b8hyyr	4633	1	The	the	DT
cord-006860-a3b8hyyr	4633	2	total	total	JJ
cord-006860-a3b8hyyr	4633	3	assay	assay	NN
cord-006860-a3b8hyyr	4633	4	time	time	NN
cord-006860-a3b8hyyr	4633	5	is	be	VBZ
cord-006860-a3b8hyyr	4633	6	of	of	IN
cord-006860-a3b8hyyr	4633	7	less	less	JJR
cord-006860-a3b8hyyr	4633	8	than	than	IN
cord-006860-a3b8hyyr	4633	9	10	10	CD
cord-006860-a3b8hyyr	4633	10	minutes	minute	NNS
cord-006860-a3b8hyyr	4633	11	and	and	CC
cord-006860-a3b8hyyr	4633	12	the	the	DT
cord-006860-a3b8hyyr	4633	13	detection	detection	NN
cord-006860-a3b8hyyr	4633	14	threshold	threshold	NN
cord-006860-a3b8hyyr	4633	15	is	be	VBZ
cord-006860-a3b8hyyr	4633	16	of	of	IN
cord-006860-a3b8hyyr	4633	17	2	2	CD
cord-006860-a3b8hyyr	4633	18	%	%	NN
cord-006860-a3b8hyyr	4634	1	There	there	EX
cord-006860-a3b8hyyr	4634	2	is	be	VBZ
cord-006860-a3b8hyyr	4634	3	no	no	DT
cord-006860-a3b8hyyr	4634	4	prozone	prozone	NN
cord-006860-a3b8hyyr	4634	5	effect	effect	NN
cord-006860-a3b8hyyr	4634	6	up	up	IN
cord-006860-a3b8hyyr	4634	7	to	to	IN
cord-006860-a3b8hyyr	4634	8	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4634	9	higher	high	JJR
cord-006860-a3b8hyyr	4634	10	than	than	IN
cord-006860-a3b8hyyr	4634	11	1,000	1,000	CD
cord-006860-a3b8hyyr	4634	12	%	%	NN
cord-006860-a3b8hyyr	4634	13	vWF	vwf	NN
cord-006860-a3b8hyyr	4634	14	.	.	.
cord-006860-a3b8hyyr	4635	1	Intra	intra	JJ
cord-006860-a3b8hyyr	4635	2	-	-	JJ
cord-006860-a3b8hyyr	4635	3	assay	assay	NN
cord-006860-a3b8hyyr	4635	4	reproducibility	reproducibility	NN
cord-006860-a3b8hyyr	4635	5	is	be	VBZ
cord-006860-a3b8hyyr	4635	6	<	<	NNP
cord-006860-a3b8hyyr	4635	7	4	4	CD
cord-006860-a3b8hyyr	4635	8	%	%	NN
cord-006860-a3b8hyyr	4635	9	and	and	CC
cord-006860-a3b8hyyr	4635	10	inter	inter	JJ
cord-006860-a3b8hyyr	4635	11	-	-	JJ
cord-006860-a3b8hyyr	4635	12	assay	assay	NN
cord-006860-a3b8hyyr	4635	13	one	one	CD
cord-006860-a3b8hyyr	4635	14	<	<	XX
cord-006860-a3b8hyyr	4635	15	5	5	CD
cord-006860-a3b8hyyr	4635	16	%	%	NN
cord-006860-a3b8hyyr	4635	17	.	.	.
cord-006860-a3b8hyyr	4636	1	In	in	IN
cord-006860-a3b8hyyr	4636	2	dilution	dilution	NN
cord-006860-a3b8hyyr	4636	3	studies	study	VBZ
cord-006860-a3b8hyyr	4636	4	a	a	DT
cord-006860-a3b8hyyr	4636	5	mean	mean	JJ
cord-006860-a3b8hyyr	4636	6	recovery	recovery	NN
cord-006860-a3b8hyyr	4636	7	of	of	IN
cord-006860-a3b8hyyr	4636	8	98	98	CD
cord-006860-a3b8hyyr	4636	9	%	%	NN
cord-006860-a3b8hyyr	4636	10	was	be	VBD
cord-006860-a3b8hyyr	4636	11	obtained	obtain	VBN
cord-006860-a3b8hyyr	4636	12	.	.	.
cord-006860-a3b8hyyr	4637	1	In	in	IN
cord-006860-a3b8hyyr	4637	2	a	a	DT
cord-006860-a3b8hyyr	4637	3	study	study	NN
cord-006860-a3b8hyyr	4637	4	on	on	IN
cord-006860-a3b8hyyr	4637	5	55	55	CD
cord-006860-a3b8hyyr	4637	6	plasma	plasma	NN
cord-006860-a3b8hyyr	4637	7	samples	sample	NNS
cord-006860-a3b8hyyr	4637	8	from	from	IN
cord-006860-a3b8hyyr	4637	9	norma~	norma~	NNP
cord-006860-a3b8hyyr	4637	10	individuals	individual	NNS
cord-006860-a3b8hyyr	4637	11	,	,	,
cord-006860-a3b8hyyr	4637	12	patients	patient	NNS
cord-006860-a3b8hyyr	4637	13	with	with	IN
cord-006860-a3b8hyyr	4637	14	high	high	JJ
cord-006860-a3b8hyyr	4637	15	vWF	vwf	NN
cord-006860-a3b8hyyr	4637	16	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4637	17	,	,	,
cord-006860-a3b8hyyr	4637	18	and	and	CC
cord-006860-a3b8hyyr	4637	19	vWd	vWd	NNS
cord-006860-a3b8hyyr	4637	20	,	,	,
cord-006860-a3b8hyyr	4637	21	comparison	comparison	NN
cord-006860-a3b8hyyr	4637	22	with	with	IN
cord-006860-a3b8hyyr	4637	23	the	the	DT
cord-006860-a3b8hyyr	4637	24	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	4637	25	technique	technique	NN
cord-006860-a3b8hyyr	4637	26	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	4637	27	a	a	DT
cord-006860-a3b8hyyr	4637	28	correlation	correlation	NN
cord-006860-a3b8hyyr	4637	29	coefficient	coefficient	NN
cord-006860-a3b8hyyr	4637	30	of	of	IN
cord-006860-a3b8hyyr	4637	31	0.997	0.997	CD
cord-006860-a3b8hyyr	4637	32	with	with	IN
cord-006860-a3b8hyyr	4637	33	a	a	DT
cord-006860-a3b8hyyr	4637	34	slope	slope	NN
cord-006860-a3b8hyyr	4637	35	of	of	IN
cord-006860-a3b8hyyr	4637	36	0.978	0.978	CD
cord-006860-a3b8hyyr	4637	37	and	and	CC
cord-006860-a3b8hyyr	4637	38	an	an	DT
cord-006860-a3b8hyyr	4637	39	intercept	intercept	NN
cord-006860-a3b8hyyr	4637	40	of	of	IN
cord-006860-a3b8hyyr	4637	41	3.30	3.30	CD
cord-006860-a3b8hyyr	4637	42	.	.	.
cord-006860-a3b8hyyr	4638	1	In	in	IN
cord-006860-a3b8hyyr	4638	2	the	the	DT
cord-006860-a3b8hyyr	4638	3	low	low	JJ
cord-006860-a3b8hyyr	4638	4	assay	assay	NN
cord-006860-a3b8hyyr	4638	5	range	range	NN
cord-006860-a3b8hyyr	4638	6	too	too	RB
cord-006860-a3b8hyyr	4638	7	,	,	,
cord-006860-a3b8hyyr	4638	8	a	a	DT
cord-006860-a3b8hyyr	4638	9	good	good	JJ
cord-006860-a3b8hyyr	4638	10	agreement	agreement	NN
cord-006860-a3b8hyyr	4638	11	was	be	VBD
cord-006860-a3b8hyyr	4638	12	obtained	obtain	VBN
cord-006860-a3b8hyyr	4638	13	with	with	IN
cord-006860-a3b8hyyr	4638	14	the	the	DT
cord-006860-a3b8hyyr	4638	15	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	4638	16	.	.	.
cord-006860-a3b8hyyr	4639	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4639	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	4639	3	that	that	IN
cord-006860-a3b8hyyr	4639	4	Liatest	Liatest	NNP
cord-006860-a3b8hyyr	4639	5	vWF	vWF	NNP
cord-006860-a3b8hyyr	4639	6	is	be	VBZ
cord-006860-a3b8hyyr	4639	7	a	a	DT
cord-006860-a3b8hyyr	4639	8	reliable	reliable	JJ
cord-006860-a3b8hyyr	4639	9	,	,	,
cord-006860-a3b8hyyr	4639	10	flexible	flexible	JJ
cord-006860-a3b8hyyr	4639	11	,	,	,
cord-006860-a3b8hyyr	4639	12	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	4639	13	,	,	,
cord-006860-a3b8hyyr	4639	14	and	and	CC
cord-006860-a3b8hyyr	4639	15	rapid	rapid	JJ
cord-006860-a3b8hyyr	4639	16	automated	automated	JJ
cord-006860-a3b8hyyr	4639	17	assay	assay	NN
cord-006860-a3b8hyyr	4639	18	which	which	WDT
cord-006860-a3b8hyyr	4639	19	fits	fit	VBZ
cord-006860-a3b8hyyr	4639	20	well	well	RB
cord-006860-a3b8hyyr	4639	21	the	the	DT
cord-006860-a3b8hyyr	4639	22	vW'F	vw'f	NN
cord-006860-a3b8hyyr	4639	23	assay	assay	NN
cord-006860-a3b8hyyr	4639	24	applications	application	NNS
cord-006860-a3b8hyyr	4639	25	in	in	IN
cord-006860-a3b8hyyr	4639	26	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4639	27	laboratories	laboratory	NNS
cord-006860-a3b8hyyr	4639	28	.	.	.
cord-006860-a3b8hyyr	4640	1	Fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	4640	2	,	,	,
cord-006860-a3b8hyyr	4640	3	the	the	DT
cord-006860-a3b8hyyr	4640	4	process	process	NN
cord-006860-a3b8hyyr	4640	5	during	during	IN
cord-006860-a3b8hyyr	4640	6	which	which	WDT
cord-006860-a3b8hyyr	4640	7	the	the	DT
cord-006860-a3b8hyyr	4640	8	active	active	JJ
cord-006860-a3b8hyyr	4640	9	enzyme	enzyme	NN
cord-006860-a3b8hyyr	4640	10	plasmin	plasmin	NN
cord-006860-a3b8hyyr	4640	11	is	be	VBZ
cord-006860-a3b8hyyr	4640	12	generated	generate	VBN
cord-006860-a3b8hyyr	4640	13	in	in	IN
cord-006860-a3b8hyyr	4640	14	a	a	DT
cord-006860-a3b8hyyr	4640	15	regulated	regulated	JJ
cord-006860-a3b8hyyr	4640	16	and	and	CC
cord-006860-a3b8hyyr	4640	17	localised	localised	JJ
cord-006860-a3b8hyyr	4640	18	way	way	NN
cord-006860-a3b8hyyr	4640	19	,	,	,
cord-006860-a3b8hyyr	4640	20	is	be	VBZ
cord-006860-a3b8hyyr	4640	21	-in	-in	:
cord-006860-a3b8hyyr	4640	22	a	a	DT
cord-006860-a3b8hyyr	4640	23	classical	classical	JJ
cord-006860-a3b8hyyr	4640	24	understanding	understanding	NN
cord-006860-a3b8hyyr	4640	25	-responsible	-responsible	NN
cord-006860-a3b8hyyr	4640	26	for	for	IN
cord-006860-a3b8hyyr	4640	27	the	the	DT
cord-006860-a3b8hyyr	4640	28	dissolution	dissolution	NN
cord-006860-a3b8hyyr	4640	29	of	of	IN
cord-006860-a3b8hyyr	4640	30	blood	blood	NN
cord-006860-a3b8hyyr	4640	31	clots	clot	NNS
cord-006860-a3b8hyyr	4640	32	formed	form	VBN
cord-006860-a3b8hyyr	4640	33	in	in	IN
cord-006860-a3b8hyyr	4640	34	a	a	DT
cord-006860-a3b8hyyr	4640	35	vessel	vessel	NN
cord-006860-a3b8hyyr	4640	36	.	.	.
cord-006860-a3b8hyyr	4641	1	For	for	IN
cord-006860-a3b8hyyr	4641	2	this	this	DT
cord-006860-a3b8hyyr	4641	3	activity	activity	NN
cord-006860-a3b8hyyr	4641	4	,	,	,
cord-006860-a3b8hyyr	4641	5	t	t	NNP
cord-006860-a3b8hyyr	4641	6	-	-	HYPH
cord-006860-a3b8hyyr	4641	7	PA	PA	NNP
cord-006860-a3b8hyyr	4641	8	is	be	VBZ
cord-006860-a3b8hyyr	4641	9	generally	generally	RB
cord-006860-a3b8hyyr	4641	10	assumed	assume	VBN
cord-006860-a3b8hyyr	4641	11	to	to	TO
cord-006860-a3b8hyyr	4641	12	be	be	VB
cord-006860-a3b8hyyr	4641	13	the	the	DT
cord-006860-a3b8hyyr	4641	14	most	most	RBS
cord-006860-a3b8hyyr	4641	15	important	important	JJ
cord-006860-a3b8hyyr	4641	16	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4641	17	activator	activator	NN
cord-006860-a3b8hyyr	4641	18	and	and	CC
cord-006860-a3b8hyyr	4641	19	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4641	20	activity	activity	NN
cord-006860-a3b8hyyr	4641	21	,	,	,
cord-006860-a3b8hyyr	4641	22	is	be	VBZ
cord-006860-a3b8hyyr	4641	23	regulated	regulate	VBN
cord-006860-a3b8hyyr	4641	24	by	by	IN
cord-006860-a3b8hyyr	4641	25	enzyme	enzyme	NN
cord-006860-a3b8hyyr	4641	26	kinetic	kinetic	JJ
cord-006860-a3b8hyyr	4641	27	mechanisms	mechanism	NNS
cord-006860-a3b8hyyr	4641	28	dependent	dependent	JJ
cord-006860-a3b8hyyr	4641	29	on	on	IN
cord-006860-a3b8hyyr	4641	30	the	the	DT
cord-006860-a3b8hyyr	4641	31	presence	presence	NN
cord-006860-a3b8hyyr	4641	32	of	of	IN
cord-006860-a3b8hyyr	4641	33	fibrin	fibrin	NN
cord-006860-a3b8hyyr	4641	34	.	.	.
cord-006860-a3b8hyyr	4642	1	With	with	IN
cord-006860-a3b8hyyr	4642	2	this	this	DT
cord-006860-a3b8hyyr	4642	3	background	background	NN
cord-006860-a3b8hyyr	4642	4	t	t	NNP
cord-006860-a3b8hyyr	4642	5	-	-	HYPH
cord-006860-a3b8hyyr	4642	6	PA	PA	NNP
cord-006860-a3b8hyyr	4642	7	is	be	VBZ
cord-006860-a3b8hyyr	4642	8	used	use	VBN
cord-006860-a3b8hyyr	4642	9	for	for	IN
cord-006860-a3b8hyyr	4642	10	thrembolytic	thrembolytic	JJ
cord-006860-a3b8hyyr	4642	11	therapy	therapy	NN
cord-006860-a3b8hyyr	4642	12	with	with	IN
cord-006860-a3b8hyyr	4642	13	great	great	JJ
cord-006860-a3b8hyyr	4642	14	success	success	NN
cord-006860-a3b8hyyr	4642	15	.	.	.
cord-006860-a3b8hyyr	4643	1	However	however	RB
cord-006860-a3b8hyyr	4643	2	,	,	,
cord-006860-a3b8hyyr	4643	3	data	datum	NNS
cord-006860-a3b8hyyr	4643	4	from	from	IN
cord-006860-a3b8hyyr	4643	5	t	t	NNP
cord-006860-a3b8hyyr	4643	6	-	-	HYPH
cord-006860-a3b8hyyr	4643	7	PA	PA	NNP
cord-006860-a3b8hyyr	4643	8	knockout	knockout	NN
cord-006860-a3b8hyyr	4643	9	mice	mouse	NNS
cord-006860-a3b8hyyr	4643	10	indicate	indicate	VBP
cord-006860-a3b8hyyr	4643	11	that	that	IN
cord-006860-a3b8hyyr	4643	12	t	t	NNP
cord-006860-a3b8hyyr	4643	13	-	-	HYPH
cord-006860-a3b8hyyr	4643	14	PA	PA	NNP
cord-006860-a3b8hyyr	4643	15	might	may	MD
cord-006860-a3b8hyyr	4643	16	not	not	RB
cord-006860-a3b8hyyr	4643	17	be	be	VB
cord-006860-a3b8hyyr	4643	18	responsible	responsible	JJ
cord-006860-a3b8hyyr	4643	19	for	for	IN
cord-006860-a3b8hyyr	4643	20	inhibiting	inhibit	VBG
cord-006860-a3b8hyyr	4643	21	the	the	DT
cord-006860-a3b8hyyr	4643	22	spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	4643	23	development	development	NN
cord-006860-a3b8hyyr	4643	24	of	of	IN
cord-006860-a3b8hyyr	4643	25	intravsacular	intravsacular	NNP
cord-006860-a3b8hyyr	4643	26	thrombi	thrombi	NNP
cord-006860-a3b8hyyr	4644	1	but	but	CC
cord-006860-a3b8hyyr	4644	2	only	only	RB
cord-006860-a3b8hyyr	4644	3	for	for	IN
cord-006860-a3b8hyyr	4644	4	dissolution	dissolution	NN
cord-006860-a3b8hyyr	4644	5	of	of	IN
cord-006860-a3b8hyyr	4644	6	fibrin	fibrin	NN
cord-006860-a3b8hyyr	4644	7	formed	form	VBN
cord-006860-a3b8hyyr	4644	8	upon	upon	IN
cord-006860-a3b8hyyr	4644	9	a	a	DT
cord-006860-a3b8hyyr	4644	10	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4644	11	challenge	challenge	NN
cord-006860-a3b8hyyr	4644	12	.	.	.
cord-006860-a3b8hyyr	4645	1	In	in	IN
cord-006860-a3b8hyyr	4645	2	contrast	contrast	NN
cord-006860-a3b8hyyr	4645	3	,	,	,
cord-006860-a3b8hyyr	4645	4	u	u	NNP
cord-006860-a3b8hyyr	4645	5	-	-	HYPH
cord-006860-a3b8hyyr	4645	6	PA	PA	NNP
cord-006860-a3b8hyyr	4645	7	,	,	,
cord-006860-a3b8hyyr	4645	8	generally	generally	RB
cord-006860-a3b8hyyr	4645	9	assumed	assume	VBN
cord-006860-a3b8hyyr	4645	10	to	to	TO
cord-006860-a3b8hyyr	4645	11	be	be	VB
cord-006860-a3b8hyyr	4645	12	important	important	JJ
cord-006860-a3b8hyyr	4645	13	for	for	IN
cord-006860-a3b8hyyr	4645	14	extravascular	extravascular	JJ
cord-006860-a3b8hyyr	4645	15	proteolytie	proteolytie	NN
cord-006860-a3b8hyyr	4645	16	activity	activity	NN
cord-006860-a3b8hyyr	4645	17	on	on	IN
cord-006860-a3b8hyyr	4645	18	activated	activate	VBN
cord-006860-a3b8hyyr	4645	19	or	or	CC
cord-006860-a3b8hyyr	4645	20	tumour	tumour	NN
cord-006860-a3b8hyyr	4645	21	cells	cell	NNS
cord-006860-a3b8hyyr	4645	22	,	,	,
cord-006860-a3b8hyyr	4645	23	seems	seem	VBZ
cord-006860-a3b8hyyr	4645	24	to	to	TO
cord-006860-a3b8hyyr	4645	25	lead	lead	VB
cord-006860-a3b8hyyr	4645	26	to	to	IN
cord-006860-a3b8hyyr	4645	27	the	the	DT
cord-006860-a3b8hyyr	4645	28	development	development	NN
cord-006860-a3b8hyyr	4645	29	of	of	IN
cord-006860-a3b8hyyr	4645	30	spontaneous	spontaneous	JJ
cord-006860-a3b8hyyr	4645	31	fibrin	fibrin	NN
cord-006860-a3b8hyyr	4645	32	formation	formation	NN
cord-006860-a3b8hyyr	4645	33	in	in	IN
cord-006860-a3b8hyyr	4645	34	a	a	DT
cord-006860-a3b8hyyr	4645	35	mouse	mouse	NN
cord-006860-a3b8hyyr	4645	36	knockout	knockout	NN
cord-006860-a3b8hyyr	4645	37	model	model	NN
cord-006860-a3b8hyyr	4645	38	.	.	.
cord-006860-a3b8hyyr	4646	1	On	on	IN
cord-006860-a3b8hyyr	4646	2	the	the	DT
cord-006860-a3b8hyyr	4646	3	other	other	JJ
cord-006860-a3b8hyyr	4646	4	hand	hand	NN
cord-006860-a3b8hyyr	4646	5	,	,	,
cord-006860-a3b8hyyr	4646	6	the	the	DT
cord-006860-a3b8hyyr	4646	7	major	major	JJ
cord-006860-a3b8hyyr	4646	8	plasminogea	plasminogea	NNP
cord-006860-a3b8hyyr	4646	9	activator	activator	NN
cord-006860-a3b8hyyr	4646	10	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4646	11	PAl	PAl	NNS
cord-006860-a3b8hyyr	4646	12	-	-	:
cord-006860-a3b8hyyr	4646	13	I	-PRON-	PRP
cord-006860-a3b8hyyr	4646	14	seems	seem	VBZ
cord-006860-a3b8hyyr	4646	15	not	not	RB
cord-006860-a3b8hyyr	4646	16	only	only	RB
cord-006860-a3b8hyyr	4646	17	to	to	TO
cord-006860-a3b8hyyr	4646	18	regulate	regulate	VB
cord-006860-a3b8hyyr	4646	19	intravascular	intravascular	JJ
cord-006860-a3b8hyyr	4646	20	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	4647	1	but	but	CC
cord-006860-a3b8hyyr	4647	2	seems	seem	VBZ
cord-006860-a3b8hyyr	4647	3	to	to	TO
cord-006860-a3b8hyyr	4647	4	also	also	RB
cord-006860-a3b8hyyr	4647	5	be	be	VB
cord-006860-a3b8hyyr	4647	6	important	important	JJ
cord-006860-a3b8hyyr	4647	7	for	for	IN
cord-006860-a3b8hyyr	4647	8	the	the	DT
cord-006860-a3b8hyyr	4647	9	progression	progression	NN
cord-006860-a3b8hyyr	4647	10	of	of	IN
cord-006860-a3b8hyyr	4647	11	vascular	vascular	JJ
cord-006860-a3b8hyyr	4647	12	diseases	disease	NNS
cord-006860-a3b8hyyr	4647	13	(	(	-LRB-
cord-006860-a3b8hyyr	4647	14	neointima	neointima	NNP
cord-006860-a3b8hyyr	4647	15	formation	formation	NN
cord-006860-a3b8hyyr	4647	16	is	be	VBZ
cord-006860-a3b8hyyr	4647	17	e.g.	e.g.	RB
cord-006860-a3b8hyyr	4647	18	increased	increase	VBN
cord-006860-a3b8hyyr	4647	19	in	in	IN
cord-006860-a3b8hyyr	4647	20	a	a	DT
cord-006860-a3b8hyyr	4647	21	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	4647	22	knockout	knockout	NN
cord-006860-a3b8hyyr	4647	23	model	model	NN
cord-006860-a3b8hyyr	4647	24	,	,	,
cord-006860-a3b8hyyr	4647	25	but	but	CC
cord-006860-a3b8hyyr	4647	26	increased	increase	VBN
cord-006860-a3b8hyyr	4647	27	levels	level	NNS
cord-006860-a3b8hyyr	4647	28	of	of	IN
cord-006860-a3b8hyyr	4647	29	PAI-1	PAI-1	NNPS
cord-006860-a3b8hyyr	4647	30	seem	seem	VBP
cord-006860-a3b8hyyr	4647	31	to	to	TO
cord-006860-a3b8hyyr	4647	32	predict	predict	VB
cord-006860-a3b8hyyr	4647	33	reocclusion	reocclusion	NN
cord-006860-a3b8hyyr	4647	34	after	after	IN
cord-006860-a3b8hyyr	4647	35	angioplasty	angioplasty	NN
cord-006860-a3b8hyyr	4647	36	)	)	-RRB-
cord-006860-a3b8hyyr	4647	37	.	.	.
cord-006860-a3b8hyyr	4648	1	In	in	IN
cord-006860-a3b8hyyr	4648	2	addition	addition	NN
cord-006860-a3b8hyyr	4648	3	to	to	IN
cord-006860-a3b8hyyr	4648	4	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4648	5	functioning	functioning	NN
cord-006860-a3b8hyyr	4648	6	as	as	IN
cord-006860-a3b8hyyr	4648	7	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	4648	8	and	and	CC
cord-006860-a3b8hyyr	4648	9	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	4648	10	,	,	,
cord-006860-a3b8hyyr	4648	11	components	component	NNS
cord-006860-a3b8hyyr	4648	12	of	of	IN
cord-006860-a3b8hyyr	4648	13	the	the	DT
cord-006860-a3b8hyyr	4648	14	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4648	15	system	system	NN
cord-006860-a3b8hyyr	4648	16	seem	seem	VBP
cord-006860-a3b8hyyr	4648	17	also	also	RB
cord-006860-a3b8hyyr	4648	18	to	to	TO
cord-006860-a3b8hyyr	4648	19	be	be	VB
cord-006860-a3b8hyyr	4648	20	involved	involve	VBN
cord-006860-a3b8hyyr	4648	21	in	in	IN
cord-006860-a3b8hyyr	4648	22	signalling	signal	VBG
cord-006860-a3b8hyyr	4648	23	processes	process	NNS
cord-006860-a3b8hyyr	4648	24	in	in	IN
cord-006860-a3b8hyyr	4648	25	tumour	tumour	NN
cord-006860-a3b8hyyr	4648	26	and	and	CC
cord-006860-a3b8hyyr	4648	27	other	other	JJ
cord-006860-a3b8hyyr	4648	28	cells	cell	NNS
cord-006860-a3b8hyyr	4648	29	.	.	.
cord-006860-a3b8hyyr	4649	1	The	the	DT
cord-006860-a3b8hyyr	4649	2	u	u	NNP
cord-006860-a3b8hyyr	4649	3	-	-	HYPH
cord-006860-a3b8hyyr	4649	4	PA	PA	NNP
cord-006860-a3b8hyyr	4649	5	/	/	SYM
cord-006860-a3b8hyyr	4649	6	u	u	NNP
cord-006860-a3b8hyyr	4649	7	-	-	HYPH
cord-006860-a3b8hyyr	4649	8	PA	PA	NNP
cord-006860-a3b8hyyr	4649	9	-	-	HYPH
cord-006860-a3b8hyyr	4649	10	receptor	receptor	NN
cord-006860-a3b8hyyr	4649	11	system	system	NN
cord-006860-a3b8hyyr	4649	12	could	could	MD
cord-006860-a3b8hyyr	4649	13	be	be	VB
cord-006860-a3b8hyyr	4649	14	shown	show	VBN
cord-006860-a3b8hyyr	4649	15	to	to	TO
cord-006860-a3b8hyyr	4649	16	function	function	VB
cord-006860-a3b8hyyr	4649	17	as	as	IN
cord-006860-a3b8hyyr	4649	18	a	a	DT
cord-006860-a3b8hyyr	4649	19	chemotactic	chemotactic	JJ
cord-006860-a3b8hyyr	4649	20	system	system	NN
cord-006860-a3b8hyyr	4649	21	and	and	CC
cord-006860-a3b8hyyr	4649	22	to	to	TO
cord-006860-a3b8hyyr	4649	23	elicit	elicit	VB
cord-006860-a3b8hyyr	4649	24	a	a	DT
cord-006860-a3b8hyyr	4649	25	migratory	migratory	JJ
cord-006860-a3b8hyyr	4649	26	and	and	CC
cord-006860-a3b8hyyr	4649	27	mitogenle	mitogenle	NN
cord-006860-a3b8hyyr	4649	28	response	response	NN
cord-006860-a3b8hyyr	4649	29	in	in	IN
cord-006860-a3b8hyyr	4649	30	monoeytes	monoeyte	NNS
cord-006860-a3b8hyyr	4649	31	and	and	CC
cord-006860-a3b8hyyr	4649	32	tumour	tumour	NN
cord-006860-a3b8hyyr	4649	33	ceils	ceil	NNS
cord-006860-a3b8hyyr	4649	34	as	as	RB
cord-006860-a3b8hyyr	4649	35	well	well	RB
cord-006860-a3b8hyyr	4649	36	as	as	IN
cord-006860-a3b8hyyr	4649	37	in	in	IN
cord-006860-a3b8hyyr	4649	38	vascular	vascular	JJ
cord-006860-a3b8hyyr	4649	39	cells	cell	NNS
cord-006860-a3b8hyyr	4649	40	.	.	.
cord-006860-a3b8hyyr	4650	1	For	for	IN
cord-006860-a3b8hyyr	4650	2	such	such	PDT
cord-006860-a3b8hyyr	4650	3	a	a	DT
cord-006860-a3b8hyyr	4650	4	response	response	NN
cord-006860-a3b8hyyr	4650	5	activation	activation	NN
cord-006860-a3b8hyyr	4650	6	of	of	IN
cord-006860-a3b8hyyr	4650	7	tyrosine	tyrosine	NN
cord-006860-a3b8hyyr	4650	8	kinases	kinase	NNS
cord-006860-a3b8hyyr	4650	9	of	of	IN
cord-006860-a3b8hyyr	4650	10	the	the	DT
cord-006860-a3b8hyyr	4650	11	sre	sre	NNS
cord-006860-a3b8hyyr	4650	12	-	-	:
cord-006860-a3b8hyyr	4650	13	family	family	NN
cord-006860-a3b8hyyr	4650	14	might	may	MD
cord-006860-a3b8hyyr	4650	15	be	be	VB
cord-006860-a3b8hyyr	4650	16	responsible	responsible	JJ
cord-006860-a3b8hyyr	4650	17	in	in	IN
cord-006860-a3b8hyyr	4650	18	some	some	DT
cord-006860-a3b8hyyr	4650	19	cell	cell	NN
cord-006860-a3b8hyyr	4650	20	lines	line	NNS
cord-006860-a3b8hyyr	4650	21	,	,	,
cord-006860-a3b8hyyr	4650	22	but	but	CC
cord-006860-a3b8hyyr	4650	23	other	other	JJ
cord-006860-a3b8hyyr	4650	24	signal	signal	NN
cord-006860-a3b8hyyr	4650	25	transduction	transduction	NN
cord-006860-a3b8hyyr	4650	26	pathways	pathway	NNS
cord-006860-a3b8hyyr	4651	1	e.g.	e.g.	RB
cord-006860-a3b8hyyr	4651	2	involving	involve	VBG
cord-006860-a3b8hyyr	4651	3	caveolae	caveolae	NNP
cord-006860-a3b8hyyr	4651	4	and	and	CC
cord-006860-a3b8hyyr	4651	5	the	the	DT
cord-006860-a3b8hyyr	4651	6	starprotein	starprotein	NNP
cord-006860-a3b8hyyr	4651	7	can	can	MD
cord-006860-a3b8hyyr	4651	8	not	not	RB
cord-006860-a3b8hyyr	4651	9	be	be	VB
cord-006860-a3b8hyyr	4651	10	excluded	exclude	VBN
cord-006860-a3b8hyyr	4651	11	.	.	.
cord-006860-a3b8hyyr	4652	1	There	there	EX
cord-006860-a3b8hyyr	4652	2	seems	seem	VBZ
cord-006860-a3b8hyyr	4652	3	to	to	TO
cord-006860-a3b8hyyr	4652	4	be	be	VB
cord-006860-a3b8hyyr	4652	5	a	a	DT
cord-006860-a3b8hyyr	4652	6	further	far	RBR
cord-006860-a3b8hyyr	4652	7	important	important	JJ
cord-006860-a3b8hyyr	4652	8	role	role	NN
cord-006860-a3b8hyyr	4652	9	of	of	IN
cord-006860-a3b8hyyr	4652	10	components	component	NNS
cord-006860-a3b8hyyr	4652	11	of	of	IN
cord-006860-a3b8hyyr	4652	12	the	the	DT
cord-006860-a3b8hyyr	4652	13	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4652	14	system	system	NN
cord-006860-a3b8hyyr	4652	15	which	which	WDT
cord-006860-a3b8hyyr	4652	16	involves	involve	VBZ
cord-006860-a3b8hyyr	4652	17	serine	serine	JJ
cord-006860-a3b8hyyr	4652	18	protease	protease	NN
cord-006860-a3b8hyyr	4652	19	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	4652	20	(	(	-LRB-
cord-006860-a3b8hyyr	4652	21	SERPINs	serpin	NNS
cord-006860-a3b8hyyr	4652	22	)	)	-RRB-
cord-006860-a3b8hyyr	4652	23	:	:	:
cord-006860-a3b8hyyr	4652	24	SERPINs	serpin	NNS
cord-006860-a3b8hyyr	4652	25	have	have	VBP
cord-006860-a3b8hyyr	4652	26	homologies	homology	NNS
cord-006860-a3b8hyyr	4652	27	to	to	IN
cord-006860-a3b8hyyr	4652	28	hormone	hormone	NN
cord-006860-a3b8hyyr	4652	29	binding	bind	VBG
cord-006860-a3b8hyyr	4652	30	proteins	protein	NNS
cord-006860-a3b8hyyr	4652	31	and	and	CC
cord-006860-a3b8hyyr	4652	32	cleavage	cleavage	NN
cord-006860-a3b8hyyr	4652	33	of	of	IN
cord-006860-a3b8hyyr	4652	34	SERPINs	serpin	NNS
cord-006860-a3b8hyyr	4652	35	by	by	IN
cord-006860-a3b8hyyr	4652	36	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4652	37	target	target	NN
cord-006860-a3b8hyyr	4652	38	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	4652	39	not	not	RB
cord-006860-a3b8hyyr	4652	40	only	only	RB
cord-006860-a3b8hyyr	4652	41	leads	lead	VBZ
cord-006860-a3b8hyyr	4652	42	to	to	IN
cord-006860-a3b8hyyr	4652	43	inactivation	inactivation	NN
cord-006860-a3b8hyyr	4652	44	of	of	IN
cord-006860-a3b8hyyr	4652	45	the	the	DT
cord-006860-a3b8hyyr	4652	46	enzyme	enzyme	NN
cord-006860-a3b8hyyr	4652	47	but	but	CC
cord-006860-a3b8hyyr	4652	48	also	also	RB
cord-006860-a3b8hyyr	4652	49	to	to	IN
cord-006860-a3b8hyyr	4652	50	a	a	DT
cord-006860-a3b8hyyr	4652	51	possible	possible	JJ
cord-006860-a3b8hyyr	4652	52	release	release	NN
cord-006860-a3b8hyyr	4652	53	of	of	IN
cord-006860-a3b8hyyr	4652	54	bound	bind	VBN
cord-006860-a3b8hyyr	4652	55	hormones	hormone	NNS
cord-006860-a3b8hyyr	4652	56	from	from	IN
cord-006860-a3b8hyyr	4652	57	the	the	DT
cord-006860-a3b8hyyr	4652	58	SERPINs	serpin	NNS
cord-006860-a3b8hyyr	4652	59	.	.	.
cord-006860-a3b8hyyr	4653	1	From	from	IN
cord-006860-a3b8hyyr	4653	2	these	these	DT
cord-006860-a3b8hyyr	4653	3	data	datum	NNS
cord-006860-a3b8hyyr	4653	4	clearly	clearly	RB
cord-006860-a3b8hyyr	4653	5	the	the	DT
cord-006860-a3b8hyyr	4653	6	relevance	relevance	NN
cord-006860-a3b8hyyr	4653	7	of	of	IN
cord-006860-a3b8hyyr	4653	8	any	any	DT
cord-006860-a3b8hyyr	4653	9	regulation	regulation	NN
cord-006860-a3b8hyyr	4653	10	of	of	IN
cord-006860-a3b8hyyr	4653	11	the	the	DT
cord-006860-a3b8hyyr	4653	12	fibrinolytie	fibrinolytie	NN
cord-006860-a3b8hyyr	4653	13	,	,	,
cord-006860-a3b8hyyr	4653	14	system	system	NN
cord-006860-a3b8hyyr	4653	15	depends	depend	VBZ
cord-006860-a3b8hyyr	4653	16	on	on	IN
cord-006860-a3b8hyyr	4653	17	the	the	DT
cord-006860-a3b8hyyr	4653	18	specific	specific	JJ
cord-006860-a3b8hyyr	4653	19	function	function	NN
cord-006860-a3b8hyyr	4653	20	of	of	IN
cord-006860-a3b8hyyr	4653	21	the	the	DT
cord-006860-a3b8hyyr	4653	22	system	system	NN
cord-006860-a3b8hyyr	4653	23	to	to	TO
cord-006860-a3b8hyyr	4653	24	be	be	VB
cord-006860-a3b8hyyr	4653	25	dealt	deal	VBN
cord-006860-a3b8hyyr	4653	26	with	with	IN
cord-006860-a3b8hyyr	4653	27	.	.	.
cord-006860-a3b8hyyr	4654	1	In	in	IN
cord-006860-a3b8hyyr	4654	2	addition	addition	NN
cord-006860-a3b8hyyr	4654	3	to	to	IN
cord-006860-a3b8hyyr	4654	4	"	"	``
cord-006860-a3b8hyyr	4654	5	fibrin	fibrin	NN
cord-006860-a3b8hyyr	4654	6	binding	binding	NN
cord-006860-a3b8hyyr	4654	7	"	"	''
cord-006860-a3b8hyyr	4654	8	,	,	,
cord-006860-a3b8hyyr	4654	9	"	"	''
cord-006860-a3b8hyyr	4654	10	receptor	receptor	NN
cord-006860-a3b8hyyr	4654	11	mediated	mediate	VBN
cord-006860-a3b8hyyr	4654	12	"	"	''
cord-006860-a3b8hyyr	4654	13	and	and	CC
cord-006860-a3b8hyyr	4654	14	"	"	``
cord-006860-a3b8hyyr	4654	15	genetic	genetic	JJ
cord-006860-a3b8hyyr	4654	16	control	control	NN
cord-006860-a3b8hyyr	4654	17	"	"	''
cord-006860-a3b8hyyr	4654	18	(	(	-LRB-
cord-006860-a3b8hyyr	4654	19	e.g.	e.g.	RB
cord-006860-a3b8hyyr	4654	20	4	4	CD
cord-006860-a3b8hyyr	4654	21	G	g	NN
cord-006860-a3b8hyyr	4654	22	vs.	vs.	NN
cord-006860-a3b8hyyr	4654	23	5	5	CD
cord-006860-a3b8hyyr	4654	24	G	g	NN
cord-006860-a3b8hyyr	4654	25	in	in	IN
cord-006860-a3b8hyyr	4654	26	the	the	DT
cord-006860-a3b8hyyr	4654	27	PAI	PAI	NNP
cord-006860-a3b8hyyr	4654	28	-	-	HYPH
cord-006860-a3b8hyyr	4654	29	I	I	NNP
cord-006860-a3b8hyyr	4654	30	promotor	promotor	NN
cord-006860-a3b8hyyr	4654	31	)	)	-RRB-
cord-006860-a3b8hyyr	4654	32	also	also	RB
cord-006860-a3b8hyyr	4654	33	"	"	``
cord-006860-a3b8hyyr	4654	34	signal	signal	JJ
cord-006860-a3b8hyyr	4654	35	transduction	transduction	NN
cord-006860-a3b8hyyr	4654	36	"	"	''
cord-006860-a3b8hyyr	4654	37	and	and	CC
cord-006860-a3b8hyyr	4654	38	"	"	``
cord-006860-a3b8hyyr	4654	39	hormone	hormone	NN
cord-006860-a3b8hyyr	4654	40	delivery	delivery	NN
cord-006860-a3b8hyyr	4654	41	"	"	''
cord-006860-a3b8hyyr	4654	42	are	be	VBP
cord-006860-a3b8hyyr	4654	43	distinct	distinct	JJ
cord-006860-a3b8hyyr	4654	44	functions	function	NNS
cord-006860-a3b8hyyr	4654	45	of	of	IN
cord-006860-a3b8hyyr	4654	46	the	the	DT
cord-006860-a3b8hyyr	4654	47	system	system	NN
cord-006860-a3b8hyyr	4654	48	with	with	IN
cord-006860-a3b8hyyr	4654	49	specific	specific	JJ
cord-006860-a3b8hyyr	4654	50	regulation	regulation	NN
cord-006860-a3b8hyyr	4654	51	.	.	.
cord-006860-a3b8hyyr	4655	1	PLASMATIC	PLASMATIC	NNP
cord-006860-a3b8hyyr	4655	2	For	for	IN
cord-006860-a3b8hyyr	4655	3	both	both	DT
cord-006860-a3b8hyyr	4655	4	,	,	,
cord-006860-a3b8hyyr	4655	5	healthy	healthy	JJ
cord-006860-a3b8hyyr	4655	6	persons	person	NNS
cord-006860-a3b8hyyr	4655	7	as	as	RB
cord-006860-a3b8hyyr	4655	8	well	well	RB
cord-006860-a3b8hyyr	4655	9	as	as	IN
cord-006860-a3b8hyyr	4655	10	for	for	IN
cord-006860-a3b8hyyr	4655	11	patients	patient	NNS
cord-006860-a3b8hyyr	4655	12	with	with	IN
cord-006860-a3b8hyyr	4655	13	angina	angina	NN
cord-006860-a3b8hyyr	4655	14	pectoris	pectoris	NN
cord-006860-a3b8hyyr	4656	1	it	-PRON-	PRP
cord-006860-a3b8hyyr	4656	2	could	could	MD
cord-006860-a3b8hyyr	4656	3	be	be	VB
cord-006860-a3b8hyyr	4656	4	shown	show	VBN
cord-006860-a3b8hyyr	4656	5	that	that	IN
cord-006860-a3b8hyyr	4656	6	increased	increase	VBN
cord-006860-a3b8hyyr	4656	7	values	value	NNS
cord-006860-a3b8hyyr	4656	8	of	of	IN
cord-006860-a3b8hyyr	4656	9	plasma	plasma	NN
cord-006860-a3b8hyyr	4656	10	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4656	11	,	,	,
cord-006860-a3b8hyyr	4656	12	factor	factor	NN
cord-006860-a3b8hyyr	4656	13	VIIc	VIIc	NNS
cord-006860-a3b8hyyr	4656	14	and	and	CC
cord-006860-a3b8hyyr	4656	15	vWF	vWF	NNP
cord-006860-a3b8hyyr	4656	16	:	:	:
cord-006860-a3b8hyyr	4656	17	ag	ag	NNP
cord-006860-a3b8hyyr	4656	18	are	be	VBP
cord-006860-a3b8hyyr	4656	19	significantly	significantly	RB
cord-006860-a3b8hyyr	4656	20	associated	associate	VBN
cord-006860-a3b8hyyr	4656	21	with	with	IN
cord-006860-a3b8hyyr	4656	22	the	the	DT
cord-006860-a3b8hyyr	4656	23	risk	risk	NN
cord-006860-a3b8hyyr	4656	24	to	to	TO
cord-006860-a3b8hyyr	4656	25	suffer	suffer	VB
cord-006860-a3b8hyyr	4656	26	an	an	DT
cord-006860-a3b8hyyr	4656	27	acute	acute	JJ
cord-006860-a3b8hyyr	4656	28	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	4656	29	infarction	infarction	NN
cord-006860-a3b8hyyr	4656	30	or	or	CC
cord-006860-a3b8hyyr	4656	31	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	4656	32	sudden	sudden	JJ
cord-006860-a3b8hyyr	4656	33	death	death	NN
cord-006860-a3b8hyyr	4656	34	.	.	.
cord-006860-a3b8hyyr	4657	1	The	the	DT
cord-006860-a3b8hyyr	4657	2	same	same	JJ
cord-006860-a3b8hyyr	4657	3	holds	hold	VBZ
cord-006860-a3b8hyyr	4657	4	for	for	IN
cord-006860-a3b8hyyr	4657	5	tPA	tPA	NNP
cord-006860-a3b8hyyr	4657	6	:	:	:
cord-006860-a3b8hyyr	4657	7	ag	ag	NNP
cord-006860-a3b8hyyr	4657	8	.	.	.
cord-006860-a3b8hyyr	4658	1	However	however	RB
cord-006860-a3b8hyyr	4658	2	,	,	,
cord-006860-a3b8hyyr	4658	3	a	a	DT
cord-006860-a3b8hyyr	4658	4	group	group	NN
cord-006860-a3b8hyyr	4658	5	analysis	analysis	NN
cord-006860-a3b8hyyr	4658	6	in	in	IN
cord-006860-a3b8hyyr	4658	7	quintiles	quintile	NNS
cord-006860-a3b8hyyr	4658	8	reveals	reveal	VBZ
cord-006860-a3b8hyyr	4658	9	that	that	IN
cord-006860-a3b8hyyr	4658	10	particularly	particularly	RB
cord-006860-a3b8hyyr	4658	11	low	low	JJ
cord-006860-a3b8hyyr	4658	12	tPA	tpa	NN
cord-006860-a3b8hyyr	4658	13	:	:	:
cord-006860-a3b8hyyr	4658	14	ag	ag	NNP
cord-006860-a3b8hyyr	4658	15	values	value	NNS
cord-006860-a3b8hyyr	4658	16	are	be	VBP
cord-006860-a3b8hyyr	4658	17	connected	connect	VBN
cord-006860-a3b8hyyr	4658	18	with	with	IN
cord-006860-a3b8hyyr	4658	19	a	a	DT
cord-006860-a3b8hyyr	4658	20	particularly	particularly	RB
cord-006860-a3b8hyyr	4658	21	low	low	JJ
cord-006860-a3b8hyyr	4658	22	coronary	coronary	JJ
cord-006860-a3b8hyyr	4658	23	risk	risk	NN
cord-006860-a3b8hyyr	4658	24	.	.	.
cord-006860-a3b8hyyr	4659	1	Unexpectedly	unexpectedly	RB
cord-006860-a3b8hyyr	4659	2	also	also	RB
cord-006860-a3b8hyyr	4659	3	the	the	DT
cord-006860-a3b8hyyr	4659	4	acute	acute	JJ
cord-006860-a3b8hyyr	4659	5	phase	phase	NN
cord-006860-a3b8hyyr	4659	6	protein	protein	NN
cord-006860-a3b8hyyr	4659	7	CRP	CRP	NNP
cord-006860-a3b8hyyr	4659	8	is	be	VBZ
cord-006860-a3b8hyyr	4659	9	positively	positively	RB
cord-006860-a3b8hyyr	4659	10	associated	associate	VBN
cord-006860-a3b8hyyr	4659	11	with	with	IN
cord-006860-a3b8hyyr	4659	12	increased	increase	VBN
cord-006860-a3b8hyyr	4659	13	coronary	coronary	JJ
cord-006860-a3b8hyyr	4659	14	risk	risk	NN
cord-006860-a3b8hyyr	4659	15	.	.	.
cord-006860-a3b8hyyr	4660	1	For	for	IN
cord-006860-a3b8hyyr	4660	2	clinical	clinical	JJ
cord-006860-a3b8hyyr	4660	3	purposes	purpose	NNS
cord-006860-a3b8hyyr	4660	4	these	these	DT
cord-006860-a3b8hyyr	4660	5	factors	factor	NNS
cord-006860-a3b8hyyr	4660	6	have	have	VBP
cord-006860-a3b8hyyr	4660	7	already	already	RB
cord-006860-a3b8hyyr	4660	8	been	be	VBN
cord-006860-a3b8hyyr	4660	9	included	include	VBN
cord-006860-a3b8hyyr	4660	10	into	into	IN
cord-006860-a3b8hyyr	4660	11	coronary	coronary	JJ
cord-006860-a3b8hyyr	4660	12	risk	risk	NN
cord-006860-a3b8hyyr	4660	13	scores	score	NNS
cord-006860-a3b8hyyr	4660	14	in	in	IN
cord-006860-a3b8hyyr	4660	15	order	order	NN
cord-006860-a3b8hyyr	4660	16	to	to	TO
cord-006860-a3b8hyyr	4660	17	improve	improve	VB
cord-006860-a3b8hyyr	4660	18	the	the	DT
cord-006860-a3b8hyyr	4660	19	individual	individual	JJ
cord-006860-a3b8hyyr	4660	20	risk	risk	NN
cord-006860-a3b8hyyr	4660	21	prediction	prediction	NN
cord-006860-a3b8hyyr	4660	22	in	in	IN
cord-006860-a3b8hyyr	4660	23	combination	combination	NN
cord-006860-a3b8hyyr	4660	24	with	with	IN
cord-006860-a3b8hyyr	4660	25	lipids	lipid	NNS
cord-006860-a3b8hyyr	4660	26	and	and	CC
cord-006860-a3b8hyyr	4660	27	other	other	JJ
cord-006860-a3b8hyyr	4660	28	risk	risk	NN
cord-006860-a3b8hyyr	4660	29	factors	factor	NNS
cord-006860-a3b8hyyr	4660	30	.	.	.
cord-006860-a3b8hyyr	4661	1	The	the	DT
cord-006860-a3b8hyyr	4661	2	assessment	assessment	NN
cord-006860-a3b8hyyr	4661	3	of	of	IN
cord-006860-a3b8hyyr	4661	4	the	the	DT
cord-006860-a3b8hyyr	4661	5	pathophysiological	pathophysiological	JJ
cord-006860-a3b8hyyr	4661	6	significance	significance	NN
cord-006860-a3b8hyyr	4661	7	of	of	IN
cord-006860-a3b8hyyr	4661	8	these	these	DT
cord-006860-a3b8hyyr	4661	9	observations	observation	NNS
cord-006860-a3b8hyyr	4661	10	remains	remain	VBZ
cord-006860-a3b8hyyr	4661	11	at	at	IN
cord-006860-a3b8hyyr	4661	12	dispute	dispute	NN
cord-006860-a3b8hyyr	4661	13	.	.	.
cord-006860-a3b8hyyr	4662	1	4	4	CD
cord-006860-a3b8hyyr	4662	2	pathways	pathway	NNS
cord-006860-a3b8hyyr	4662	3	are	be	VBP
cord-006860-a3b8hyyr	4662	4	discussed	discuss	VBN
cord-006860-a3b8hyyr	4662	5	:	:	:
cord-006860-a3b8hyyr	4662	6	1	1	CD
cord-006860-a3b8hyyr	4662	7	.	.	.
cord-006860-a3b8hyyr	4663	1	The	the	DT
cord-006860-a3b8hyyr	4663	2	assumption	assumption	NN
cord-006860-a3b8hyyr	4663	3	that	that	IN
cord-006860-a3b8hyyr	4663	4	increased	increase	VBD
cord-006860-a3b8hyyr	4663	5	plasma	plasma	NN
cord-006860-a3b8hyyr	4663	6	values	value	NNS
cord-006860-a3b8hyyr	4663	7	of	of	IN
cord-006860-a3b8hyyr	4663	8	those	those	DT
cord-006860-a3b8hyyr	4663	9	factors	factor	NNS
cord-006860-a3b8hyyr	4663	10	indicate	indicate	VBP
cord-006860-a3b8hyyr	4663	11	increased	increase	VBN
cord-006860-a3b8hyyr	4663	12	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4663	13	activity	activity	NN
cord-006860-a3b8hyyr	4663	14	could	could	MD
cord-006860-a3b8hyyr	4663	15	so	so	RB
cord-006860-a3b8hyyr	4663	16	far	far	RB
cord-006860-a3b8hyyr	4663	17	not	not	RB
cord-006860-a3b8hyyr	4663	18	be	be	VB
cord-006860-a3b8hyyr	4663	19	established	establish	VBN
cord-006860-a3b8hyyr	4663	20	in	in	IN
cord-006860-a3b8hyyr	4663	21	prospective	prospective	JJ
cord-006860-a3b8hyyr	4663	22	studies	study	NNS
cord-006860-a3b8hyyr	4663	23	.	.	.
cord-006860-a3b8hyyr	4664	1	2	2	LS
cord-006860-a3b8hyyr	4664	2	.	.	.
cord-006860-a3b8hyyr	4665	1	Both	both	DT
cord-006860-a3b8hyyr	4665	2	vWF	vWF	NNP
cord-006860-a3b8hyyr	4665	3	:	:	:
cord-006860-a3b8hyyr	4665	4	ag	ag	NNP
cord-006860-a3b8hyyr	4665	5	and	and	CC
cord-006860-a3b8hyyr	4665	6	tPA	tPA	NNP
cord-006860-a3b8hyyr	4666	1	:	:	:
cord-006860-a3b8hyyr	4666	2	ag	ag	NNP
cord-006860-a3b8hyyr	4666	3	are	be	VBP
cord-006860-a3b8hyyr	4666	4	produced	produce	VBN
cord-006860-a3b8hyyr	4666	5	in	in	IN
cord-006860-a3b8hyyr	4666	6	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4666	7	cells	cell	NNS
cord-006860-a3b8hyyr	4666	8	.	.	.
cord-006860-a3b8hyyr	4667	1	An	an	DT
cord-006860-a3b8hyyr	4667	2	increase	increase	NN
cord-006860-a3b8hyyr	4667	3	of	of	IN
cord-006860-a3b8hyyr	4667	4	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4667	5	plasma	plasma	NN
cord-006860-a3b8hyyr	4667	6	level	level	NN
cord-006860-a3b8hyyr	4667	7	could	could	MD
cord-006860-a3b8hyyr	4667	8	therefore	therefore	RB
cord-006860-a3b8hyyr	4667	9	indicate	indicate	VB
cord-006860-a3b8hyyr	4667	10	increased	increase	VBN
cord-006860-a3b8hyyr	4667	11	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4667	12	cell	cell	NN
cord-006860-a3b8hyyr	4667	13	functions	function	NNS
cord-006860-a3b8hyyr	4667	14	which	which	WDT
cord-006860-a3b8hyyr	4667	15	accompanies	accompany	VBZ
cord-006860-a3b8hyyr	4667	16	progressive	progressive	JJ
cord-006860-a3b8hyyr	4667	17	atheromatosis	atheromatosis	NN
cord-006860-a3b8hyyr	4667	18	.	.	.
cord-006860-a3b8hyyr	4668	1	The	the	DT
cord-006860-a3b8hyyr	4668	2	risk	risk	NN
cord-006860-a3b8hyyr	4668	3	association	association	NN
cord-006860-a3b8hyyr	4668	4	of	of	IN
cord-006860-a3b8hyyr	4668	5	the	the	DT
cord-006860-a3b8hyyr	4668	6	two	two	CD
cord-006860-a3b8hyyr	4668	7	acute	acute	JJ
cord-006860-a3b8hyyr	4668	8	phase	phase	NN
cord-006860-a3b8hyyr	4668	9	proteins	protein	VBZ
cord-006860-a3b8hyyr	4668	10	CRP	crp	NN
cord-006860-a3b8hyyr	4668	11	and	and	CC
cord-006860-a3b8hyyr	4668	12	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4668	13	could	could	MD
cord-006860-a3b8hyyr	4668	14	be	be	VB
cord-006860-a3b8hyyr	4668	15	interpreted	interpret	VBN
cord-006860-a3b8hyyr	4668	16	analogously	analogously	RB
cord-006860-a3b8hyyr	4668	17	.	.	.
cord-006860-a3b8hyyr	4669	1	3	3	LS
cord-006860-a3b8hyyr	4669	2	.	.	.
cord-006860-a3b8hyyr	4670	1	First	first	JJ
cord-006860-a3b8hyyr	4670	2	prospective	prospective	JJ
cord-006860-a3b8hyyr	4670	3	studies	study	NNS
cord-006860-a3b8hyyr	4670	4	favour	favour	VBP
cord-006860-a3b8hyyr	4670	5	the	the	DT
cord-006860-a3b8hyyr	4670	6	assumption	assumption	NN
cord-006860-a3b8hyyr	4670	7	of	of	IN
cord-006860-a3b8hyyr	4670	8	a	a	DT
cord-006860-a3b8hyyr	4670	9	genetic	genetic	JJ
cord-006860-a3b8hyyr	4670	10	determination	determination	NN
cord-006860-a3b8hyyr	4670	11	to	to	IN
cord-006860-a3b8hyyr	4670	12	an	an	DT
cord-006860-a3b8hyyr	4670	13	increased	increase	VBN
cord-006860-a3b8hyyr	4670	14	production	production	NN
cord-006860-a3b8hyyr	4670	15	of	of	IN
cord-006860-a3b8hyyr	4670	16	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4670	17	proteins	protein	NNS
cord-006860-a3b8hyyr	4670	18	in	in	IN
cord-006860-a3b8hyyr	4670	19	persons	person	NNS
cord-006860-a3b8hyyr	4670	20	at	at	IN
cord-006860-a3b8hyyr	4670	21	particular	particular	JJ
cord-006860-a3b8hyyr	4670	22	coronary	coronary	JJ
cord-006860-a3b8hyyr	4670	23	risk	risk	NN
cord-006860-a3b8hyyr	4670	24	.	.	.
cord-006860-a3b8hyyr	4671	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	4671	2	could	could	MD
cord-006860-a3b8hyyr	4671	3	also	also	RB
cord-006860-a3b8hyyr	4671	4	be	be	VB
cord-006860-a3b8hyyr	4671	5	shown	show	VBN
cord-006860-a3b8hyyr	4671	6	that	that	IN
cord-006860-a3b8hyyr	4671	7	there	there	EX
cord-006860-a3b8hyyr	4671	8	is	be	VBZ
cord-006860-a3b8hyyr	4671	9	a	a	DT
cord-006860-a3b8hyyr	4671	10	certain	certain	JJ
cord-006860-a3b8hyyr	4671	11	dependance	dependance	NN
cord-006860-a3b8hyyr	4671	12	of	of	IN
cord-006860-a3b8hyyr	4671	13	the	the	DT
cord-006860-a3b8hyyr	4671	14	gene	gene	NN
cord-006860-a3b8hyyr	4671	15	-	-	HYPH
cord-006860-a3b8hyyr	4671	16	polymorphism	polymorphism	NN
cord-006860-a3b8hyyr	4671	17	for	for	IN
cord-006860-a3b8hyyr	4671	18	co	co	NN
cord-006860-a3b8hyyr	4671	19	-	-	NN
cord-006860-a3b8hyyr	4671	20	and	and	CC
cord-006860-a3b8hyyr	4671	21	13-fibrinogen	13-fibrinogen	CD
cord-006860-a3b8hyyr	4671	22	chains	chain	NNS
cord-006860-a3b8hyyr	4671	23	from	from	IN
cord-006860-a3b8hyyr	4671	24	the	the	DT
cord-006860-a3b8hyyr	4671	25	coronary	coronary	JJ
cord-006860-a3b8hyyr	4671	26	risk	risk	NN
cord-006860-a3b8hyyr	4671	27	.	.	.
cord-006860-a3b8hyyr	4672	1	4	4	LS
cord-006860-a3b8hyyr	4672	2	.	.	.
cord-006860-a3b8hyyr	4673	1	Even	even	RB
cord-006860-a3b8hyyr	4673	2	slightly	slightly	RB
cord-006860-a3b8hyyr	4673	3	elevated	elevated	JJ
cord-006860-a3b8hyyr	4673	4	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4673	5	of	of	IN
cord-006860-a3b8hyyr	4673	6	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4673	7	and/or	and/or	CC
cord-006860-a3b8hyyr	4673	8	vWF	vWF	NNP
cord-006860-a3b8hyyr	4673	9	:	:	:
cord-006860-a3b8hyyr	4673	10	ag	ag	NNP
cord-006860-a3b8hyyr	4673	11	may	may	MD
cord-006860-a3b8hyyr	4673	12	influence	influence	VB
cord-006860-a3b8hyyr	4673	13	the	the	DT
cord-006860-a3b8hyyr	4673	14	quality	quality	NN
cord-006860-a3b8hyyr	4673	15	of	of	IN
cord-006860-a3b8hyyr	4673	16	a	a	DT
cord-006860-a3b8hyyr	4673	17	coronary	coronary	JJ
cord-006860-a3b8hyyr	4673	18	thrombus	thrombus	NN
cord-006860-a3b8hyyr	4673	19	both	both	DT
cord-006860-a3b8hyyr	4673	20	by	by	IN
cord-006860-a3b8hyyr	4673	21	increased	increase	VBN
cord-006860-a3b8hyyr	4673	22	physical	physical	JJ
cord-006860-a3b8hyyr	4673	23	stability	stability	NN
cord-006860-a3b8hyyr	4673	24	and	and	CC
cord-006860-a3b8hyyr	4673	25	by	by	IN
cord-006860-a3b8hyyr	4673	26	reduced	reduce	VBN
cord-006860-a3b8hyyr	4673	27	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4673	28	lysibility	lysibility	NN
cord-006860-a3b8hyyr	4673	29	.	.	.
cord-006860-a3b8hyyr	4674	1	This	this	DT
cord-006860-a3b8hyyr	4674	2	could	could	MD
cord-006860-a3b8hyyr	4674	3	mean	mean	VB
cord-006860-a3b8hyyr	4674	4	that	that	IN
cord-006860-a3b8hyyr	4674	5	an	an	DT
cord-006860-a3b8hyyr	4674	6	early	early	JJ
cord-006860-a3b8hyyr	4674	7	coronary	coronary	JJ
cord-006860-a3b8hyyr	4674	8	clot	clot	NN
cord-006860-a3b8hyyr	4674	9	under	under	IN
cord-006860-a3b8hyyr	4674	10	these	these	DT
cord-006860-a3b8hyyr	4674	11	conditions	condition	NNS
cord-006860-a3b8hyyr	4674	12	could	could	MD
cord-006860-a3b8hyyr	4674	13	more	more	RBR
cord-006860-a3b8hyyr	4674	14	readily	readily	RB
cord-006860-a3b8hyyr	4674	15	develop	develop	VB
cord-006860-a3b8hyyr	4674	16	to	to	IN
cord-006860-a3b8hyyr	4674	17	a	a	DT
cord-006860-a3b8hyyr	4674	18	stable	stable	JJ
cord-006860-a3b8hyyr	4674	19	,	,	,
cord-006860-a3b8hyyr	4674	20	Occlusive	occlusive	JJ
cord-006860-a3b8hyyr	4674	21	thrombus	thrombus	NN
cord-006860-a3b8hyyr	4674	22	.	.	.
cord-006860-a3b8hyyr	4675	1	A	a	DT
cord-006860-a3b8hyyr	4675	2	newborn	newborn	JJ
cord-006860-a3b8hyyr	4675	3	with	with	IN
cord-006860-a3b8hyyr	4675	4	pronounced	pronounced	JJ
cord-006860-a3b8hyyr	4675	5	bleeding	bleeding	JJ
cord-006860-a3b8hyyr	4675	6	tendency	tendency	NN
cord-006860-a3b8hyyr	4675	7	had	have	VBD
cord-006860-a3b8hyyr	4675	8	a	a	DT
cord-006860-a3b8hyyr	4675	9	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4675	10	(	(	-LRB-
cord-006860-a3b8hyyr	4675	11	prth	prth	NN
cord-006860-a3b8hyyr	4675	12	)	)	-RRB-
cord-006860-a3b8hyyr	4675	13	deficiency	deficiency	NN
cord-006860-a3b8hyyr	4675	14	below	below	IN
cord-006860-a3b8hyyr	4675	15	2.8	2.8	CD
cord-006860-a3b8hyyr	4675	16	%	%	NN
cord-006860-a3b8hyyr	4675	17	in	in	IN
cord-006860-a3b8hyyr	4675	18	a	a	DT
cord-006860-a3b8hyyr	4675	19	clotting	clotting	NN
cord-006860-a3b8hyyr	4675	20	assay	assay	NN
cord-006860-a3b8hyyr	4675	21	.	.	.
cord-006860-a3b8hyyr	4676	1	Both	both	DT
cord-006860-a3b8hyyr	4676	2	parents	parent	NNS
cord-006860-a3b8hyyr	4676	3	had	have	VBD
cord-006860-a3b8hyyr	4676	4	activities	activity	NNS
cord-006860-a3b8hyyr	4676	5	of	of	IN
cord-006860-a3b8hyyr	4676	6	71	71	CD
cord-006860-a3b8hyyr	4676	7	%	%	NN
cord-006860-a3b8hyyr	4676	8	and	and	CC
cord-006860-a3b8hyyr	4676	9	69	69	CD
cord-006860-a3b8hyyr	4676	10	%	%	NN
cord-006860-a3b8hyyr	4676	11	,	,	,
cord-006860-a3b8hyyr	4676	12	respectively	respectively	RB
cord-006860-a3b8hyyr	4676	13	.	.	.
cord-006860-a3b8hyyr	4677	1	However	however	RB
cord-006860-a3b8hyyr	4677	2	,	,	,
cord-006860-a3b8hyyr	4677	3	the	the	DT
cord-006860-a3b8hyyr	4677	4	immunological	immunological	JJ
cord-006860-a3b8hyyr	4677	5	determination	determination	NN
cord-006860-a3b8hyyr	4677	6	ofprth	ofprth	JJ
cord-006860-a3b8hyyr	4677	7	by	by	IN
cord-006860-a3b8hyyr	4677	8	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	4677	9	revealed	reveal	VBD
cord-006860-a3b8hyyr	4677	10	normal	normal	JJ
cord-006860-a3b8hyyr	4677	11	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4677	12	in	in	IN
cord-006860-a3b8hyyr	4677	13	all	all	DT
cord-006860-a3b8hyyr	4677	14	family	family	NN
cord-006860-a3b8hyyr	4677	15	members	member	NNS
cord-006860-a3b8hyyr	4677	16	(	(	-LRB-
cord-006860-a3b8hyyr	4677	17	93%-101	93%-101	CD
cord-006860-a3b8hyyr	4677	18	%	%	NN
cord-006860-a3b8hyyr	4677	19	)	)	-RRB-
cord-006860-a3b8hyyr	4677	20	.	.	.
cord-006860-a3b8hyyr	4678	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	4678	2	,	,	,
cord-006860-a3b8hyyr	4678	3	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	4678	4	generation	generation	NN
cord-006860-a3b8hyyr	4678	5	as	as	IN
cord-006860-a3b8hyyr	4678	6	investigated	investigate	VBN
cord-006860-a3b8hyyr	4678	7	by	by	IN
cord-006860-a3b8hyyr	4678	8	a	a	DT
cord-006860-a3b8hyyr	4678	9	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	4678	10	assay	assay	NN
cord-006860-a3b8hyyr	4678	11	using	use	VBG
cord-006860-a3b8hyyr	4678	12	ecarin	ecarin	NNP
cord-006860-a3b8hyyr	4678	13	for	for	IN
cord-006860-a3b8hyyr	4678	14	activation	activation	NN
cord-006860-a3b8hyyr	4678	15	of	of	IN
cord-006860-a3b8hyyr	4678	16	prth	prth	NN
cord-006860-a3b8hyyr	4678	17	was	be	VBD
cord-006860-a3b8hyyr	4678	18	normal	normal	JJ
cord-006860-a3b8hyyr	4678	19	as	as	RB
cord-006860-a3b8hyyr	4678	20	well	well	RB
cord-006860-a3b8hyyr	4678	21	.	.	.
cord-006860-a3b8hyyr	4679	1	Activation	activation	NN
cord-006860-a3b8hyyr	4679	2	of	of	IN
cord-006860-a3b8hyyr	4679	3	prth	prth	NN
cord-006860-a3b8hyyr	4679	4	by	by	IN
cord-006860-a3b8hyyr	4679	5	FXa	FXa	NNS
cord-006860-a3b8hyyr	4679	6	was	be	VBD
cord-006860-a3b8hyyr	4679	7	investigated	investigate	VBN
cord-006860-a3b8hyyr	4679	8	by	by	IN
cord-006860-a3b8hyyr	4679	9	reealcificafion	reealcificafion	NN
cord-006860-a3b8hyyr	4679	10	of	of	IN
cord-006860-a3b8hyyr	4679	11	the	the	DT
cord-006860-a3b8hyyr	4679	12	plasma	plasma	NN
cord-006860-a3b8hyyr	4679	13	samples	sample	NNS
cord-006860-a3b8hyyr	4679	14	and	and	CC
cord-006860-a3b8hyyr	4679	15	further	further	RB
cord-006860-a3b8hyyr	4679	16	analyzed	analyze	VBN
cord-006860-a3b8hyyr	4679	17	for	for	IN
cord-006860-a3b8hyyr	4679	18	prth	prth	NN
cord-006860-a3b8hyyr	4679	19	and	and	CC
cord-006860-a3b8hyyr	4679	20	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4679	21	derivatives	derivative	NNS
cord-006860-a3b8hyyr	4679	22	produced	produce	VBN
cord-006860-a3b8hyyr	4679	23	.	.	.
cord-006860-a3b8hyyr	4680	1	Although	although	IN
cord-006860-a3b8hyyr	4680	2	clotting	clotting	NN
cord-006860-a3b8hyyr	4680	3	times	time	NNS
cord-006860-a3b8hyyr	4680	4	still	still	RB
cord-006860-a3b8hyyr	4680	5	were	be	VBD
cord-006860-a3b8hyyr	4680	6	different	different	JJ
cord-006860-a3b8hyyr	4680	7	,	,	,
cord-006860-a3b8hyyr	4680	8	finally	finally	RB
cord-006860-a3b8hyyr	4680	9	,	,	,
cord-006860-a3b8hyyr	4680	10	normal	normal	JJ
cord-006860-a3b8hyyr	4680	11	levels	level	NNS
cord-006860-a3b8hyyr	4680	12	of	of	IN
cord-006860-a3b8hyyr	4680	13	Fl+2	Fl+2	NNS
cord-006860-a3b8hyyr	4680	14	and	and	CC
cord-006860-a3b8hyyr	4680	15	TAT	TAT	NNP
cord-006860-a3b8hyyr	4680	16	were	be	VBD
cord-006860-a3b8hyyr	4680	17	generated	generate	VBN
cord-006860-a3b8hyyr	4680	18	as	as	IN
cord-006860-a3b8hyyr	4680	19	determined	determine	VBN
cord-006860-a3b8hyyr	4680	20	by	by	IN
cord-006860-a3b8hyyr	4680	21	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	4680	22	.	.	.
cord-006860-a3b8hyyr	4681	1	Western	western	JJ
cord-006860-a3b8hyyr	4681	2	blot	blot	NN
cord-006860-a3b8hyyr	4681	3	analysis	analysis	NN
cord-006860-a3b8hyyr	4681	4	using	use	VBG
cord-006860-a3b8hyyr	4681	5	polyclonal	polyclonal	JJ
cord-006860-a3b8hyyr	4681	6	(	(	-LRB-
cord-006860-a3b8hyyr	4681	7	rabbit	rabbit	NN
cord-006860-a3b8hyyr	4681	8	)	)	-RRB-
cord-006860-a3b8hyyr	4681	9	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4681	10	to	to	TO
cord-006860-a3b8hyyr	4681	11	prth	prth	VB
cord-006860-a3b8hyyr	4681	12	and	and	CC
cord-006860-a3b8hyyr	4681	13	a	a	DT
cord-006860-a3b8hyyr	4681	14	monclonal	monclonal	JJ
cord-006860-a3b8hyyr	4681	15	antibody	antibody	NN
cord-006860-a3b8hyyr	4681	16	specific	specific	JJ
cord-006860-a3b8hyyr	4681	17	to	to	IN
cord-006860-a3b8hyyr	4681	18	human	human	JJ
cord-006860-a3b8hyyr	4681	19	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4681	20	,	,	,
cord-006860-a3b8hyyr	4681	21	revealed	reveal	VBD
cord-006860-a3b8hyyr	4681	22	different	different	JJ
cord-006860-a3b8hyyr	4681	23	patterns	pattern	NNS
cord-006860-a3b8hyyr	4681	24	of	of	IN
cord-006860-a3b8hyyr	4681	25	prth	prth	JJ
cord-006860-a3b8hyyr	4681	26	degradation	degradation	NN
cord-006860-a3b8hyyr	4681	27	products	product	NNS
cord-006860-a3b8hyyr	4681	28	.	.	.
cord-006860-a3b8hyyr	4682	1	TAT	TAT	NNP
cord-006860-a3b8hyyr	4682	2	was	be	VBD
cord-006860-a3b8hyyr	4682	3	only	only	RB
cord-006860-a3b8hyyr	4682	4	weakly	weakly	RB
cord-006860-a3b8hyyr	4682	5	visible	visible	JJ
cord-006860-a3b8hyyr	4682	6	in	in	IN
cord-006860-a3b8hyyr	4682	7	the	the	DT
cord-006860-a3b8hyyr	4682	8	serum	serum	NN
cord-006860-a3b8hyyr	4682	9	of	of	IN
cord-006860-a3b8hyyr	4682	10	the	the	DT
cord-006860-a3b8hyyr	4682	11	mother	mother	NN
cord-006860-a3b8hyyr	4682	12	and	and	CC
cord-006860-a3b8hyyr	4682	13	nearly	nearly	RB
cord-006860-a3b8hyyr	4682	14	absent	absent	JJ
cord-006860-a3b8hyyr	4682	15	in	in	IN
cord-006860-a3b8hyyr	4682	16	the	the	DT
cord-006860-a3b8hyyr	4682	17	child	child	NN
cord-006860-a3b8hyyr	4682	18	.	.	.
cord-006860-a3b8hyyr	4683	1	The	the	DT
cord-006860-a3b8hyyr	4683	2	mobility	mobility	NN
cord-006860-a3b8hyyr	4683	3	of	of	IN
cord-006860-a3b8hyyr	4683	4	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4683	5	and	and	CC
cord-006860-a3b8hyyr	4683	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4683	7	was	be	VBD
cord-006860-a3b8hyyr	4683	8	different	different	JJ
cord-006860-a3b8hyyr	4683	9	compared	compare	VBN
cord-006860-a3b8hyyr	4683	10	to	to	IN
cord-006860-a3b8hyyr	4683	11	normals	normal	NNS
cord-006860-a3b8hyyr	4683	12	indicating	indicate	VBG
cord-006860-a3b8hyyr	4683	13	a	a	DT
cord-006860-a3b8hyyr	4683	14	lower	low	JJR
cord-006860-a3b8hyyr	4683	15	molecular	molecular	JJ
cord-006860-a3b8hyyr	4683	16	weight	weight	NN
cord-006860-a3b8hyyr	4683	17	.	.	.
cord-006860-a3b8hyyr	4684	1	After	after	IN
cord-006860-a3b8hyyr	4684	2	reduction	reduction	NN
cord-006860-a3b8hyyr	4684	3	of	of	IN
cord-006860-a3b8hyyr	4684	4	disulfide	disulfide	NN
cord-006860-a3b8hyyr	4684	5	bridges	bridge	NNS
cord-006860-a3b8hyyr	4684	6	a	a	DT
cord-006860-a3b8hyyr	4684	7	higher	high	JJR
cord-006860-a3b8hyyr	4684	8	molecular	molecular	JJ
cord-006860-a3b8hyyr	4684	9	weight	weight	NN
cord-006860-a3b8hyyr	4684	10	of	of	IN
cord-006860-a3b8hyyr	4684	11	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4684	12	was	be	VBD
cord-006860-a3b8hyyr	4684	13	observed	observe	VBN
cord-006860-a3b8hyyr	4684	14	compared	compare	VBN
cord-006860-a3b8hyyr	4684	15	to	to	IN
cord-006860-a3b8hyyr	4684	16	normals	normal	NNS
cord-006860-a3b8hyyr	4684	17	indicating	indicate	VBG
cord-006860-a3b8hyyr	4684	18	an	an	DT
cord-006860-a3b8hyyr	4684	19	insufficient	insufficient	JJ
cord-006860-a3b8hyyr	4684	20	cleavage	cleavage	NN
cord-006860-a3b8hyyr	4684	21	ofprth	ofprth	RB
cord-006860-a3b8hyyr	4684	22	and	and	CC
cord-006860-a3b8hyyr	4684	23	formation	formation	NN
cord-006860-a3b8hyyr	4684	24	ofprethrombin	ofprethrombin	NNP
cord-006860-a3b8hyyr	4684	25	2	2	CD
cord-006860-a3b8hyyr	4684	26	.	.	.
cord-006860-a3b8hyyr	4685	1	These	these	DT
cord-006860-a3b8hyyr	4685	2	observations	observation	NNS
cord-006860-a3b8hyyr	4685	3	let	let	VBP
cord-006860-a3b8hyyr	4685	4	suggest	suggest	VB
cord-006860-a3b8hyyr	4685	5	that	that	DT
cord-006860-a3b8hyyr	4685	6	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4685	7	Marburg	Marburg	NNP
cord-006860-a3b8hyyr	4685	8	is	be	VBZ
cord-006860-a3b8hyyr	4685	9	a	a	DT
cord-006860-a3b8hyyr	4685	10	deletion	deletion	NN
cord-006860-a3b8hyyr	4685	11	mutant	mutant	NN
cord-006860-a3b8hyyr	4685	12	lacking	lack	VBG
cord-006860-a3b8hyyr	4685	13	the	the	DT
cord-006860-a3b8hyyr	4685	14	cleavage	cleavage	NN
cord-006860-a3b8hyyr	4685	15	region	region	NN
cord-006860-a3b8hyyr	4685	16	Arg	arg	NN
cord-006860-a3b8hyyr	4685	17	320-Ile321	320-ile321	CD
cord-006860-a3b8hyyr	4685	18	.	.	.
cord-006860-a3b8hyyr	4686	1	Upon	upon	IN
cord-006860-a3b8hyyr	4686	2	cleavage	cleavage	NN
cord-006860-a3b8hyyr	4686	3	by	by	IN
cord-006860-a3b8hyyr	4686	4	factor	factor	NN
cord-006860-a3b8hyyr	4686	5	Xa	Xa	NNP
cord-006860-a3b8hyyr	4686	6	only	only	RB
cord-006860-a3b8hyyr	4686	7	prethrombin	prethrombin	NNP
cord-006860-a3b8hyyr	4686	8	2	2	CD
cord-006860-a3b8hyyr	4686	9	is	be	VBZ
cord-006860-a3b8hyyr	4686	10	formed	form	VBN
cord-006860-a3b8hyyr	4686	11	under	under	IN
cord-006860-a3b8hyyr	4686	12	liberation	liberation	NN
cord-006860-a3b8hyyr	4686	13	of	of	IN
cord-006860-a3b8hyyr	4686	14	Fl+2	Fl+2	NNS
cord-006860-a3b8hyyr	4686	15	.	.	.
cord-006860-a3b8hyyr	4687	1	This	this	DT
cord-006860-a3b8hyyr	4687	2	prethrombin	prethrombin	NN
cord-006860-a3b8hyyr	4687	3	2	2	CD
cord-006860-a3b8hyyr	4687	4	is	be	VBZ
cord-006860-a3b8hyyr	4687	5	able	able	JJ
cord-006860-a3b8hyyr	4687	6	to	to	TO
cord-006860-a3b8hyyr	4687	7	cleave	cleave	VB
cord-006860-a3b8hyyr	4687	8	chromogenic	chromogenic	JJ
cord-006860-a3b8hyyr	4687	9	substrates	substrate	NNS
cord-006860-a3b8hyyr	4687	10	in	in	IN
cord-006860-a3b8hyyr	4687	11	the	the	DT
cord-006860-a3b8hyyr	4687	12	ecarin	ecarin	NNP
cord-006860-a3b8hyyr	4687	13	assay	assay	NN
cord-006860-a3b8hyyr	4687	14	.	.	.
cord-006860-a3b8hyyr	4688	1	Probably	probably	RB
cord-006860-a3b8hyyr	4688	2	,	,	,
cord-006860-a3b8hyyr	4688	3	prethrombin	prethrombin	NNP
cord-006860-a3b8hyyr	4688	4	2	2	CD
cord-006860-a3b8hyyr	4688	5	forms	form	VBZ
cord-006860-a3b8hyyr	4688	6	a	a	DT
cord-006860-a3b8hyyr	4688	7	complex	complex	NN
cord-006860-a3b8hyyr	4688	8	with	with	IN
cord-006860-a3b8hyyr	4688	9	ATIII	ATIII	NNP
cord-006860-a3b8hyyr	4688	10	which	which	WDT
cord-006860-a3b8hyyr	4688	11	is	be	VBZ
cord-006860-a3b8hyyr	4688	12	detected	detect	VBN
cord-006860-a3b8hyyr	4688	13	by	by	IN
cord-006860-a3b8hyyr	4688	14	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	4688	15	,	,	,
cord-006860-a3b8hyyr	4688	16	but	but	CC
cord-006860-a3b8hyyr	4688	17	unstable	unstable	JJ
cord-006860-a3b8hyyr	4688	18	under	under	IN
cord-006860-a3b8hyyr	4688	19	denaturing	denaturing	JJ
cord-006860-a3b8hyyr	4688	20	conditions	condition	NNS
cord-006860-a3b8hyyr	4688	21	as	as	IN
cord-006860-a3b8hyyr	4688	22	in	in	IN
cord-006860-a3b8hyyr	4688	23	the	the	DT
cord-006860-a3b8hyyr	4688	24	Western	western	JJ
cord-006860-a3b8hyyr	4688	25	blot	blot	NN
cord-006860-a3b8hyyr	4688	26	.	.	.
cord-006860-a3b8hyyr	4689	1	As	as	IN
cord-006860-a3b8hyyr	4689	2	a	a	DT
cord-006860-a3b8hyyr	4689	3	major	major	JJ
cord-006860-a3b8hyyr	4689	4	complication	complication	NN
cord-006860-a3b8hyyr	4689	5	of	of	IN
cord-006860-a3b8hyyr	4689	6	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	4689	7	A	a	DT
cord-006860-a3b8hyyr	4689	8	treatment	treatment	NN
cord-006860-a3b8hyyr	4689	9	,	,	,
cord-006860-a3b8hyyr	4689	10	up	up	IN
cord-006860-a3b8hyyr	4689	11	to	to	TO
cord-006860-a3b8hyyr	4689	12	30	30	CD
cord-006860-a3b8hyyr	4689	13	%	%	NN
cord-006860-a3b8hyyr	4689	14	of	of	IN
cord-006860-a3b8hyyr	4689	15	the	the	DT
cord-006860-a3b8hyyr	4689	16	severely	severely	RB
cord-006860-a3b8hyyr	4689	17	affected	affect	VBN
cord-006860-a3b8hyyr	4689	18	patients	patient	NNS
cord-006860-a3b8hyyr	4689	19	develop	develop	VBP
cord-006860-a3b8hyyr	4689	20	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4689	21	to	to	IN
cord-006860-a3b8hyyr	4689	22	substituted	substitute	VBN
cord-006860-a3b8hyyr	4689	23	factor	factor	NN
cord-006860-a3b8hyyr	4689	24	VIII	VIII	NNP
cord-006860-a3b8hyyr	4689	25	.	.	.
cord-006860-a3b8hyyr	4690	1	Investigating	investigate	VBG
cord-006860-a3b8hyyr	4690	2	133	133	CD
cord-006860-a3b8hyyr	4690	3	patients	patient	NNS
cord-006860-a3b8hyyr	4690	4	and	and	CC
cord-006860-a3b8hyyr	4690	5	considering	consider	VBG
cord-006860-a3b8hyyr	4690	6	the	the	DT
cord-006860-a3b8hyyr	4690	7	data	datum	NNS
cord-006860-a3b8hyyr	4690	8	of	of	IN
cord-006860-a3b8hyyr	4690	9	further	further	JJ
cord-006860-a3b8hyyr	4690	10	231	231	CD
cord-006860-a3b8hyyr	4690	11	patients	patient	NNS
cord-006860-a3b8hyyr	4690	12	of	of	IN
cord-006860-a3b8hyyr	4690	13	the	the	DT
cord-006860-a3b8hyyr	4690	14	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	4690	15	database	database	NN
cord-006860-a3b8hyyr	4690	16	,	,	,
cord-006860-a3b8hyyr	4690	17	we	-PRON-	PRP
cord-006860-a3b8hyyr	4690	18	could	could	MD
cord-006860-a3b8hyyr	4690	19	show	show	VB
cord-006860-a3b8hyyr	4690	20	,	,	,
cord-006860-a3b8hyyr	4690	21	that	that	DT
cord-006860-a3b8hyyr	4690	22	risk	risk	NN
cord-006860-a3b8hyyr	4690	23	of	of	IN
cord-006860-a3b8hyyr	4690	24	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4690	25	developement	developement	NNP
cord-006860-a3b8hyyr	4690	26	depends	depend	VBZ
cord-006860-a3b8hyyr	4690	27	on	on	IN
cord-006860-a3b8hyyr	4690	28	the	the	DT
cord-006860-a3b8hyyr	4690	29	patient	patient	NN
cord-006860-a3b8hyyr	4690	30	's	's	POS
cord-006860-a3b8hyyr	4690	31	mutation	mutation	NN
cord-006860-a3b8hyyr	4690	32	type	type	NN
cord-006860-a3b8hyyr	4690	33	.	.	.
cord-006860-a3b8hyyr	4691	1	Patients	patient	NNS
cord-006860-a3b8hyyr	4691	2	with	with	IN
cord-006860-a3b8hyyr	4691	3	more	more	RBR
cord-006860-a3b8hyyr	4691	4	severe	severe	JJ
cord-006860-a3b8hyyr	4691	5	gene	gene	NN
cord-006860-a3b8hyyr	4691	6	defects	defect	NNS
cord-006860-a3b8hyyr	4691	7	,	,	,
cord-006860-a3b8hyyr	4691	8	like	like	IN
cord-006860-a3b8hyyr	4691	9	intron	intron	NN
cord-006860-a3b8hyyr	4691	10	22	22	CD
cord-006860-a3b8hyyr	4691	11	inversions	inversion	NNS
cord-006860-a3b8hyyr	4691	12	,	,	,
cord-006860-a3b8hyyr	4691	13	stop	stop	VB
cord-006860-a3b8hyyr	4691	14	mutations	mutation	NNS
cord-006860-a3b8hyyr	4691	15	or	or	CC
cord-006860-a3b8hyyr	4691	16	large	large	JJ
cord-006860-a3b8hyyr	4691	17	deletions	deletion	NNS
cord-006860-a3b8hyyr	4691	18	had	have	VBD
cord-006860-a3b8hyyr	4691	19	a	a	DT
cord-006860-a3b8hyyr	4691	20	risk	risk	NN
cord-006860-a3b8hyyr	4691	21	of	of	IN
cord-006860-a3b8hyyr	4691	22	about	about	RB
cord-006860-a3b8hyyr	4691	23	35	35	CD
cord-006860-a3b8hyyr	4691	24	%	%	NN
cord-006860-a3b8hyyr	4691	25	for	for	IN
cord-006860-a3b8hyyr	4691	26	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4691	27	developement	developement	NNP
cord-006860-a3b8hyyr	4691	28	,	,	,
cord-006860-a3b8hyyr	4691	29	which	which	WDT
cord-006860-a3b8hyyr	4691	30	was	be	VBD
cord-006860-a3b8hyyr	4691	31	about	about	RB
cord-006860-a3b8hyyr	4691	32	7	7	CD
cord-006860-a3b8hyyr	4691	33	times	time	NNS
cord-006860-a3b8hyyr	4691	34	higher	high	JJR
cord-006860-a3b8hyyr	4691	35	than	than	IN
cord-006860-a3b8hyyr	4691	36	for	for	IN
cord-006860-a3b8hyyr	4691	37	missense	missense	NN
cord-006860-a3b8hyyr	4691	38	mutations	mutation	NNS
cord-006860-a3b8hyyr	4691	39	or	or	CC
cord-006860-a3b8hyyr	4691	40	small	small	JJ
cord-006860-a3b8hyyr	4691	41	deletions	deletion	NNS
cord-006860-a3b8hyyr	4691	42	.	.	.
cord-006860-a3b8hyyr	4692	1	Besides	besides	IN
cord-006860-a3b8hyyr	4692	2	an	an	DT
cord-006860-a3b8hyyr	4692	3	influence	influence	NN
cord-006860-a3b8hyyr	4692	4	of	of	IN
cord-006860-a3b8hyyr	4692	5	mutation	mutation	NN
cord-006860-a3b8hyyr	4692	6	type	type	NN
cord-006860-a3b8hyyr	4692	7	,	,	,
cord-006860-a3b8hyyr	4692	8	we	-PRON-	PRP
cord-006860-a3b8hyyr	4692	9	investigated	investigate	VBD
cord-006860-a3b8hyyr	4692	10	other	other	JJ
cord-006860-a3b8hyyr	4692	11	parameters	parameter	NNS
cord-006860-a3b8hyyr	4692	12	e.	e.	NNP
cord-006860-a3b8hyyr	4692	13	g.	g.	NNP
cord-006860-a3b8hyyr	4692	14	immune	immune	NNP
cord-006860-a3b8hyyr	4692	15	response	response	NN
cord-006860-a3b8hyyr	4692	16	genes	gene	NNS
cord-006860-a3b8hyyr	4692	17	(	(	-LRB-
cord-006860-a3b8hyyr	4692	18	I	I	NNP
cord-006860-a3b8hyyr	4692	19	-	-	HYPH
cord-006860-a3b8hyyr	4692	20	ILA	ILA	NNP
cord-006860-a3b8hyyr	4692	21	-	-	HYPH
cord-006860-a3b8hyyr	4692	22	genotype	genotype	NNP
cord-006860-a3b8hyyr	4692	23	)	)	-RRB-
cord-006860-a3b8hyyr	4692	24	and	and	CC
cord-006860-a3b8hyyr	4692	25	clinical	clinical	JJ
cord-006860-a3b8hyyr	4692	26	aspects	aspect	NNS
cord-006860-a3b8hyyr	4692	27	(	(	-LRB-
cord-006860-a3b8hyyr	4692	28	treatment	treatment	NN
cord-006860-a3b8hyyr	4692	29	onset	onset	NN
cord-006860-a3b8hyyr	4692	30	and	and	CC
cord-006860-a3b8hyyr	4692	31	frequency	frequency	NN
cord-006860-a3b8hyyr	4692	32	,	,	,
cord-006860-a3b8hyyr	4692	33	type	type	NN
cord-006860-a3b8hyyr	4692	34	of	of	IN
cord-006860-a3b8hyyr	4692	35	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4692	36	)	)	-RRB-
cord-006860-a3b8hyyr	4692	37	that	that	WDT
cord-006860-a3b8hyyr	4692	38	might	may	MD
cord-006860-a3b8hyyr	4692	39	also	also	RB
cord-006860-a3b8hyyr	4692	40	affect	affect	VB
cord-006860-a3b8hyyr	4692	41	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4692	42	formation	formation	NN
cord-006860-a3b8hyyr	4692	43	.	.	.
cord-006860-a3b8hyyr	4693	1	To	to	TO
cord-006860-a3b8hyyr	4693	2	exclude	exclude	VB
cord-006860-a3b8hyyr	4693	3	any	any	DT
cord-006860-a3b8hyyr	4693	4	effect	effect	NN
cord-006860-a3b8hyyr	4693	5	of	of	IN
cord-006860-a3b8hyyr	4693	6	mutation	mutation	NN
cord-006860-a3b8hyyr	4693	7	type	type	NN
cord-006860-a3b8hyyr	4693	8	,	,	,
cord-006860-a3b8hyyr	4693	9	we	-PRON-	PRP
cord-006860-a3b8hyyr	4693	10	focussed	focusse	VBD
cord-006860-a3b8hyyr	4693	11	on	on	IN
cord-006860-a3b8hyyr	4693	12	72	72	CD
cord-006860-a3b8hyyr	4693	13	patients	patient	NNS
cord-006860-a3b8hyyr	4693	14	with	with	IN
cord-006860-a3b8hyyr	4693	15	an	an	DT
cord-006860-a3b8hyyr	4693	16	intron	intron	NN
cord-006860-a3b8hyyr	4693	17	22	22	CD
cord-006860-a3b8hyyr	4693	18	inversion	inversion	NN
cord-006860-a3b8hyyr	4693	19	.	.	.
cord-006860-a3b8hyyr	4694	1	HLA	HLA	NNP
cord-006860-a3b8hyyr	4694	2	-	-	HYPH
cord-006860-a3b8hyyr	4694	3	typing	typing	NN
cord-006860-a3b8hyyr	4694	4	showed	show	VBD
cord-006860-a3b8hyyr	4694	5	that	that	IN
cord-006860-a3b8hyyr	4694	6	some	some	DT
cord-006860-a3b8hyyr	4694	7	t	t	NNP
cord-006860-a3b8hyyr	4694	8	-	-	HYPH
cord-006860-a3b8hyyr	4694	9	ILA	ILA	NNP
cord-006860-a3b8hyyr	4694	10	-	-	HYPH
cord-006860-a3b8hyyr	4694	11	alleles	allele	NNS
cord-006860-a3b8hyyr	4694	12	(	(	-LRB-
cord-006860-a3b8hyyr	4694	13	DQB0602	dqb0602	XX
cord-006860-a3b8hyyr	4694	14	,	,	,
cord-006860-a3b8hyyr	4694	15	BT	BT	NNP
cord-006860-a3b8hyyr	4694	16	)	)	-RRB-
cord-006860-a3b8hyyr	4694	17	occurred	occur	VBD
cord-006860-a3b8hyyr	4694	18	more	more	JJR
cord-006860-a3b8hyyr	4694	19	otten	otten	NN
cord-006860-a3b8hyyr	4694	20	and	and	CC
cord-006860-a3b8hyyr	4694	21	others	other	NNS
cord-006860-a3b8hyyr	4694	22	(	(	-LRB-
cord-006860-a3b8hyyr	4694	23	DQA103	DQA103	NNP
cord-006860-a3b8hyyr	4694	24	,	,	,
cord-006860-a3b8hyyr	4694	25	DQB603	DQB603	NNP
cord-006860-a3b8hyyr	4694	26	,	,	,
cord-006860-a3b8hyyr	4694	27	DR13	DR13	NNP
cord-006860-a3b8hyyr	4694	28	,	,	,
cord-006860-a3b8hyyr	4694	29	C2	C2	NNP
cord-006860-a3b8hyyr	4694	30	)	)	-RRB-
cord-006860-a3b8hyyr	4694	31	less	less	RBR
cord-006860-a3b8hyyr	4694	32	frequent	frequent	JJ
cord-006860-a3b8hyyr	4694	33	in	in	IN
cord-006860-a3b8hyyr	4694	34	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4694	35	patients	patient	NNS
cord-006860-a3b8hyyr	4694	36	.	.	.
cord-006860-a3b8hyyr	4695	1	Treatment	treatment	NN
cord-006860-a3b8hyyr	4695	2	onset	onset	NN
cord-006860-a3b8hyyr	4695	3	,	,	,
cord-006860-a3b8hyyr	4695	4	frequency	frequency	NN
cord-006860-a3b8hyyr	4695	5	and	and	CC
cord-006860-a3b8hyyr	4695	6	type	type	NN
cord-006860-a3b8hyyr	4695	7	of	of	IN
cord-006860-a3b8hyyr	4695	8	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4695	9	apparently	apparently	RB
cord-006860-a3b8hyyr	4695	10	do	do	VBP
cord-006860-a3b8hyyr	4695	11	not	not	RB
cord-006860-a3b8hyyr	4695	12	affect	affect	VB
cord-006860-a3b8hyyr	4695	13	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4695	14	incidence	incidence	NN
cord-006860-a3b8hyyr	4695	15	.	.	.
cord-006860-a3b8hyyr	4696	1	The	the	DT
cord-006860-a3b8hyyr	4696	2	results	result	NNS
cord-006860-a3b8hyyr	4696	3	presented	present	VBN
cord-006860-a3b8hyyr	4696	4	here	here	RB
cord-006860-a3b8hyyr	4696	5	,	,	,
cord-006860-a3b8hyyr	4696	6	prove	prove	VB
cord-006860-a3b8hyyr	4696	7	that	that	IN
cord-006860-a3b8hyyr	4696	8	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4696	9	development	development	NN
cord-006860-a3b8hyyr	4696	10	is	be	VBZ
cord-006860-a3b8hyyr	4696	11	considerably	considerably	RB
cord-006860-a3b8hyyr	4696	12	influenced	influence	VBN
cord-006860-a3b8hyyr	4696	13	by	by	IN
cord-006860-a3b8hyyr	4696	14	the	the	DT
cord-006860-a3b8hyyr	4696	15	mutation	mutation	NN
cord-006860-a3b8hyyr	4696	16	type	type	NN
cord-006860-a3b8hyyr	4696	17	.	.	.
cord-006860-a3b8hyyr	4697	1	This	this	DT
cord-006860-a3b8hyyr	4697	2	supports	support	VBZ
cord-006860-a3b8hyyr	4697	3	the	the	DT
cord-006860-a3b8hyyr	4697	4	hypothesis	hypothesis	NN
cord-006860-a3b8hyyr	4697	5	that	that	IN
cord-006860-a3b8hyyr	4697	6	patients	patient	NNS
cord-006860-a3b8hyyr	4697	7	with	with	IN
cord-006860-a3b8hyyr	4697	8	severe	severe	JJ
cord-006860-a3b8hyyr	4697	9	molecular	molecular	JJ
cord-006860-a3b8hyyr	4697	10	defects	defect	NNS
cord-006860-a3b8hyyr	4697	11	have	have	VBP
cord-006860-a3b8hyyr	4697	12	no	no	DT
cord-006860-a3b8hyyr	4697	13	endogenous	endogenous	JJ
cord-006860-a3b8hyyr	4697	14	factor	factor	NN
cord-006860-a3b8hyyr	4697	15	VIII	VIII	NNP
cord-006860-a3b8hyyr	4697	16	protein	protein	NN
cord-006860-a3b8hyyr	4697	17	and	and	CC
cord-006860-a3b8hyyr	4697	18	that	that	IN
cord-006860-a3b8hyyr	4697	19	substituted	substitute	VBN
cord-006860-a3b8hyyr	4697	20	factor	factor	NN
cord-006860-a3b8hyyr	4697	21	VIII	VIII	NNP
cord-006860-a3b8hyyr	4697	22	represents	represent	VBZ
cord-006860-a3b8hyyr	4697	23	a	a	DT
cord-006860-a3b8hyyr	4697	24	foreign	foreign	JJ
cord-006860-a3b8hyyr	4697	25	protein	protein	NN
cord-006860-a3b8hyyr	4697	26	,	,	,
cord-006860-a3b8hyyr	4697	27	leading	lead	VBG
cord-006860-a3b8hyyr	4697	28	to	to	IN
cord-006860-a3b8hyyr	4697	29	an	an	DT
cord-006860-a3b8hyyr	4697	30	immune	immune	JJ
cord-006860-a3b8hyyr	4697	31	response	response	NN
cord-006860-a3b8hyyr	4697	32	,	,	,
cord-006860-a3b8hyyr	4697	33	e.	e.	NNP
cord-006860-a3b8hyyr	4697	34	g.	g.	NNP
cord-006860-a3b8hyyr	4698	1	the	the	DT
cord-006860-a3b8hyyr	4698	2	production	production	NN
cord-006860-a3b8hyyr	4698	3	of	of	IN
cord-006860-a3b8hyyr	4698	4	alloantibodies	alloantibody	NNS
cord-006860-a3b8hyyr	4698	5	.	.	.
cord-006860-a3b8hyyr	4699	1	In	in	IN
cord-006860-a3b8hyyr	4699	2	addition	addition	NN
cord-006860-a3b8hyyr	4699	3	,	,	,
cord-006860-a3b8hyyr	4699	4	the	the	DT
cord-006860-a3b8hyyr	4699	5	immune	immune	JJ
cord-006860-a3b8hyyr	4699	6	response	response	NN
cord-006860-a3b8hyyr	4699	7	seems	seem	VBZ
cord-006860-a3b8hyyr	4699	8	to	to	TO
cord-006860-a3b8hyyr	4699	9	be	be	VB
cord-006860-a3b8hyyr	4699	10	modified	modify	VBN
cord-006860-a3b8hyyr	4699	11	by	by	IN
cord-006860-a3b8hyyr	4699	12	the	the	DT
cord-006860-a3b8hyyr	4699	13	HLA	HLA	NNP
cord-006860-a3b8hyyr	4699	14	-	-	HYPH
cord-006860-a3b8hyyr	4699	15	genotype	genotype	NN
cord-006860-a3b8hyyr	4699	16	.	.	.
cord-006860-a3b8hyyr	4700	1	However	however	RB
cord-006860-a3b8hyyr	4700	2	oar	oar	JJ
cord-006860-a3b8hyyr	4700	3	findings	finding	NNS
cord-006860-a3b8hyyr	4700	4	(	(	-LRB-
cord-006860-a3b8hyyr	4700	5	in	in	IN
cord-006860-a3b8hyyr	4700	6	terms	term	NNS
cord-006860-a3b8hyyr	4700	7	of	of	IN
cord-006860-a3b8hyyr	4700	8	genotype	genotype	NN
cord-006860-a3b8hyyr	4700	9	and	and	CC
cord-006860-a3b8hyyr	4700	10	treatment	treatment	NN
cord-006860-a3b8hyyr	4700	11	parameters	parameter	NNS
cord-006860-a3b8hyyr	4700	12	)	)	-RRB-
cord-006860-a3b8hyyr	4700	13	can	can	MD
cord-006860-a3b8hyyr	4700	14	only	only	RB
cord-006860-a3b8hyyr	4700	15	explain	explain	VB
cord-006860-a3b8hyyr	4700	16	part	part	NN
cord-006860-a3b8hyyr	4700	17	of	of	IN
cord-006860-a3b8hyyr	4700	18	the	the	DT
cord-006860-a3b8hyyr	4700	19	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4700	20	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	4700	21	.	.	.
cord-006860-a3b8hyyr	4701	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	4701	2	is	be	VBZ
cord-006860-a3b8hyyr	4701	3	still	still	RB
cord-006860-a3b8hyyr	4701	4	unsolved	unsolved	JJ
cord-006860-a3b8hyyr	4701	5	why	why	WRB
cord-006860-a3b8hyyr	4701	6	substituted	substituted	JJ
cord-006860-a3b8hyyr	4701	7	factor	factor	NN
cord-006860-a3b8hyyr	4701	8	VIII	VIII	NNP
cord-006860-a3b8hyyr	4701	9	does	do	VBZ
cord-006860-a3b8hyyr	4701	10	not	not	RB
cord-006860-a3b8hyyr	4701	11	lead	lead	VB
cord-006860-a3b8hyyr	4701	12	to	to	IN
cord-006860-a3b8hyyr	4701	13	a	a	DT
cord-006860-a3b8hyyr	4701	14	recognizable	recognizable	JJ
cord-006860-a3b8hyyr	4701	15	immune	immune	JJ
cord-006860-a3b8hyyr	4701	16	response	response	NN
cord-006860-a3b8hyyr	4701	17	in	in	IN
cord-006860-a3b8hyyr	4701	18	2/3	2/3	CD
cord-006860-a3b8hyyr	4701	19	of	of	IN
cord-006860-a3b8hyyr	4701	20	the	the	DT
cord-006860-a3b8hyyr	4701	21	patients	patient	NNS
cord-006860-a3b8hyyr	4701	22	with	with	IN
cord-006860-a3b8hyyr	4701	23	severe	severe	JJ
cord-006860-a3b8hyyr	4701	24	molecular	molecular	JJ
cord-006860-a3b8hyyr	4701	25	factor	factor	NN
cord-006860-a3b8hyyr	4701	26	VIII	VIII	NNP
cord-006860-a3b8hyyr	4701	27	gene	gene	NN
cord-006860-a3b8hyyr	4701	28	defects	defect	NNS
cord-006860-a3b8hyyr	4701	29	.	.	.
cord-006860-a3b8hyyr	4702	1	Consequently	consequently	RB
cord-006860-a3b8hyyr	4702	2	other	other	JJ
cord-006860-a3b8hyyr	4702	3	factors	factor	NNS
cord-006860-a3b8hyyr	4702	4	,	,	,
cord-006860-a3b8hyyr	4702	5	probably	probably	RB
cord-006860-a3b8hyyr	4702	6	concerning	concern	VBG
cord-006860-a3b8hyyr	4702	7	the	the	DT
cord-006860-a3b8hyyr	4702	8	antenatal	antenatal	JJ
cord-006860-a3b8hyyr	4702	9	phase	phase	NN
cord-006860-a3b8hyyr	4702	10	,	,	,
cord-006860-a3b8hyyr	4702	11	must	must	MD
cord-006860-a3b8hyyr	4702	12	be	be	VB
cord-006860-a3b8hyyr	4702	13	involved	involve	VBN
cord-006860-a3b8hyyr	4702	14	.	.	.
cord-006860-a3b8hyyr	4703	1	ViIa	ViIa	NNP
cord-006860-a3b8hyyr	4703	2	IN	in	IN
cord-006860-a3b8hyyr	4703	3	THE	the	DT
cord-006860-a3b8hyyr	4703	4	TREATMENT	treatment	NN
cord-006860-a3b8hyyr	4703	5	 	 	_SP
cord-006860-a3b8hyyr	4703	6	OF	of	IN
cord-006860-a3b8hyyr	4703	7	PATIENTS	patient	NNS
cord-006860-a3b8hyyr	4703	8	WITH	with	IN
cord-006860-a3b8hyyr	4703	9	INHIBITORS	INHIBITORS	NNP
cord-006860-a3b8hyyr	4703	10	AGAINST	against	IN
cord-006860-a3b8hyyr	4703	11	FACTOR	factor	NN
cord-006860-a3b8hyyr	4704	1	VIII	VIII	NNP
cord-006860-a3b8hyyr	4704	2	OR	or	CC
cord-006860-a3b8hyyr	4704	3	IX	IX	NNP
cord-006860-a3b8hyyr	4704	4	:	:	:
cord-006860-a3b8hyyr	4704	5	 	 	_SP
cord-006860-a3b8hyyr	4705	1	A	a	DT
cord-006860-a3b8hyyr	4705	2	GERMAN	GERMAN	NNP
cord-006860-a3b8hyyr	4705	3	/	/	SYM
cord-006860-a3b8hyyr	4705	4	SWISS	swiss	JJ
cord-006860-a3b8hyyr	4705	5	/	/	SYM
cord-006860-a3b8hyyr	4705	6	AUSTRIAN	AUSTRIAN	NNP
cord-006860-a3b8hyyr	4705	7	MULTI	MULTI	NNP
cord-006860-a3b8hyyr	4705	8	~	~	NNP
cord-006860-a3b8hyyr	4705	9	CENTER	CENTER	NNP
cord-006860-a3b8hyyr	4705	10	TRIAL	TRIAL	NNP
cord-006860-a3b8hyyr	4705	11	 	 	_SP
cord-006860-a3b8hyyr	4705	12	D.	D.	NNP
cord-006860-a3b8hyyr	4705	13	Ellbriiek	Ellbriiek	NNP
cord-006860-a3b8hyyr	4706	1	*	*	NFP
cord-006860-a3b8hyyr	4706	2	,	,	,
cord-006860-a3b8hyyr	4706	3	I.	I.	NNP
cord-006860-a3b8hyyr	4706	4	Scharrer	Scharrer	NNP
cord-006860-a3b8hyyr	4707	1	*	*	NFP
cord-006860-a3b8hyyr	4707	2	*	*	NFP
cord-006860-a3b8hyyr	4707	3	,	,	,
cord-006860-a3b8hyyr	4707	4	J.	J.	NNP
cord-006860-a3b8hyyr	4707	5	Dethling	Dethling	NNP
cord-006860-a3b8hyyr	4708	1	*	*	NFP
cord-006860-a3b8hyyr	4708	2	*	*	NFP
cord-006860-a3b8hyyr	4708	3	*	*	NFP
cord-006860-a3b8hyyr	4708	4	,	,	,
cord-006860-a3b8hyyr	4708	5	and	and	CC
cord-006860-a3b8hyyr	4708	6	the	the	DT
cord-006860-a3b8hyyr	4708	7	rFVIIa	rFVIIa	NNP
cord-006860-a3b8hyyr	4708	8	Study	Study	NNP
cord-006860-a3b8hyyr	4708	9	Group	Group	NNP
cord-006860-a3b8hyyr	4708	10	*	*	NFP
cord-006860-a3b8hyyr	4708	11	Section	section	NN
cord-006860-a3b8hyyr	4708	12	H	h	NN
cord-006860-a3b8hyyr	4708	13	~	~	NFP
cord-006860-a3b8hyyr	4708	14	mostaseology	mostaseology	NN
cord-006860-a3b8hyyr	4708	15	,	,	,
cord-006860-a3b8hyyr	4708	16	University	University	NNP
cord-006860-a3b8hyyr	4708	17	Ulm	Ulm	NNP
cord-006860-a3b8hyyr	4708	18	*	*	NFP
cord-006860-a3b8hyyr	4708	19	*	*	NFP
cord-006860-a3b8hyyr	4708	20	Dept	Dept	NNP
cord-006860-a3b8hyyr	4708	21	.	.	NNP
cord-006860-a3b8hyyr	4708	22	of	of	IN
cord-006860-a3b8hyyr	4708	23	Angiology	Angiology	NNP
cord-006860-a3b8hyyr	4708	24	,	,	,
cord-006860-a3b8hyyr	4708	25	JWG	JWG	NNP
cord-006860-a3b8hyyr	4708	26	-	-	HYPH
cord-006860-a3b8hyyr	4708	27	University	University	NNP
cord-006860-a3b8hyyr	4708	28	Hospital	Hospital	NNP
cord-006860-a3b8hyyr	4708	29	Frankfurt	Frankfurt	NNP
cord-006860-a3b8hyyr	4709	1	a.	a.	NN
cord-006860-a3b8hyyr	4710	1	M.	M.	NNP
cord-006860-a3b8hyyr	4710	2	*	*	NFP
cord-006860-a3b8hyyr	4710	3	*	*	NFP
cord-006860-a3b8hyyr	4710	4	*	*	NFP
cord-006860-a3b8hyyr	4710	5	Novo	Novo	NNP
cord-006860-a3b8hyyr	4710	6	Nordisk	Nordisk	NNP
cord-006860-a3b8hyyr	4710	7	,	,	,
cord-006860-a3b8hyyr	4710	8	Mainz	Mainz	NNP
cord-006860-a3b8hyyr	4710	9	Administration	Administration	NNP
cord-006860-a3b8hyyr	4710	10	of	of	IN
cord-006860-a3b8hyyr	4710	11	activated	activate	VBN
cord-006860-a3b8hyyr	4710	12	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	4710	13	Factor	Factor	NNP
cord-006860-a3b8hyyr	4710	14	VII	VII	NNP
cord-006860-a3b8hyyr	4710	15	(	(	-LRB-
cord-006860-a3b8hyyr	4710	16	rFVIIa	rfviia	NN
cord-006860-a3b8hyyr	4710	17	)	)	-RRB-
cord-006860-a3b8hyyr	4710	18	can	can	MD
cord-006860-a3b8hyyr	4710	19	by	by	IN
cord-006860-a3b8hyyr	4710	20	-	-	HYPH
cord-006860-a3b8hyyr	4710	21	pass	pass	VB
cord-006860-a3b8hyyr	4710	22	the	the	DT
cord-006860-a3b8hyyr	4710	23	FVnlWlX	fvnlwlx	NN
cord-006860-a3b8hyyr	4710	24	pathway	pathway	NN
cord-006860-a3b8hyyr	4710	25	and	and	CC
cord-006860-a3b8hyyr	4710	26	offers	offer	VBZ
cord-006860-a3b8hyyr	4710	27	an	an	DT
cord-006860-a3b8hyyr	4710	28	alternative	alternative	JJ
cord-006860-a3b8hyyr	4710	29	treatment	treatment	NN
cord-006860-a3b8hyyr	4710	30	for	for	IN
cord-006860-a3b8hyyr	4710	31	patients	patient	NNS
cord-006860-a3b8hyyr	4710	32	with	with	IN
cord-006860-a3b8hyyr	4710	33	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4710	34	(	(	-LRB-
cord-006860-a3b8hyyr	4710	35	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	4710	36	)	)	-RRB-
cord-006860-a3b8hyyr	4710	37	against	against	IN
cord-006860-a3b8hyyr	4710	38	these	these	DT
cord-006860-a3b8hyyr	4710	39	factors	factor	NNS
cord-006860-a3b8hyyr	4710	40	.	.	.
cord-006860-a3b8hyyr	4711	1	From	from	IN
cord-006860-a3b8hyyr	4711	2	November	November	NNP
cord-006860-a3b8hyyr	4711	3	1994	1994	CD
cord-006860-a3b8hyyr	4711	4	to	to	IN
cord-006860-a3b8hyyr	4711	5	October	October	NNP
cord-006860-a3b8hyyr	4711	6	1995	1995	CD
cord-006860-a3b8hyyr	4711	7	,	,	,
cord-006860-a3b8hyyr	4711	8	a	a	DT
cord-006860-a3b8hyyr	4711	9	total	total	NN
cord-006860-a3b8hyyr	4711	10	of	of	IN
cord-006860-a3b8hyyr	4711	11	25	25	CD
cord-006860-a3b8hyyr	4711	12	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4711	13	episodes	episode	NNS
cord-006860-a3b8hyyr	4711	14	and	and	CC
cord-006860-a3b8hyyr	4711	15	10	10	CD
cord-006860-a3b8hyyr	4711	16	surgical	surgical	JJ
cord-006860-a3b8hyyr	4711	17	interventions	intervention	NNS
cord-006860-a3b8hyyr	4711	18	in	in	IN
cord-006860-a3b8hyyr	4711	19	18	18	CD
cord-006860-a3b8hyyr	4711	20	patients	patient	NNS
cord-006860-a3b8hyyr	4711	21	were	be	VBD
cord-006860-a3b8hyyr	4711	22	treated	treat	VBN
cord-006860-a3b8hyyr	4711	23	with	with	IN
cord-006860-a3b8hyyr	4711	24	rFVIIa	rfviia	NN
cord-006860-a3b8hyyr	4711	25	in	in	IN
cord-006860-a3b8hyyr	4711	26	a	a	DT
cord-006860-a3b8hyyr	4711	27	phase	phase	NN
cord-006860-a3b8hyyr	4711	28	IIIb	iiib	NN
cord-006860-a3b8hyyr	4711	29	multicenter	multicenter	JJ
cord-006860-a3b8hyyr	4711	30	trial	trial	NN
cord-006860-a3b8hyyr	4711	31	.	.	.
cord-006860-a3b8hyyr	4712	1	Diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	4712	2	was	be	VBD
cord-006860-a3b8hyyr	4713	1	hemophilia	hemophilia	NNP
cord-006860-a3b8hyyr	4713	2	A	A	NNP
cord-006860-a3b8hyyr	4713	3	(	(	-LRB-
cord-006860-a3b8hyyr	4713	4	n	n	NN
cord-006860-a3b8hyyr	4713	5	=	=	SYM
cord-006860-a3b8hyyr	4713	6	15	15	CD
cord-006860-a3b8hyyr	4713	7	)	)	-RRB-
cord-006860-a3b8hyyr	4713	8	or	or	CC
cord-006860-a3b8hyyr	4713	9	B	B	NNP
cord-006860-a3b8hyyr	4713	10	(	(	-LRB-
cord-006860-a3b8hyyr	4713	11	n	n	NN
cord-006860-a3b8hyyr	4713	12	=	=	NN
cord-006860-a3b8hyyr	4713	13	l	l	NN
cord-006860-a3b8hyyr	4713	14	)	)	-RRB-
cord-006860-a3b8hyyr	4713	15	with	with	IN
cord-006860-a3b8hyyr	4713	16	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4713	17	,	,	,
cord-006860-a3b8hyyr	4713	18	and	and	CC
cord-006860-a3b8hyyr	4713	19	acquired	acquire	VBD
cord-006860-a3b8hyyr	4713	20	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4713	21	against	against	IN
cord-006860-a3b8hyyr	4713	22	Factor	Factor	NNP
cord-006860-a3b8hyyr	4713	23	VIII	VIII	NNP
cord-006860-a3b8hyyr	4713	24	(	(	-LRB-
cord-006860-a3b8hyyr	4713	25	n=2	n=2	NNS
cord-006860-a3b8hyyr	4713	26	)	)	-RRB-
cord-006860-a3b8hyyr	4713	27	.	.	.
cord-006860-a3b8hyyr	4714	1	Various	various	JJ
cord-006860-a3b8hyyr	4714	2	serious	serious	JJ
cord-006860-a3b8hyyr	4714	3	bleeds	bleed	NNS
cord-006860-a3b8hyyr	4714	4	,	,	,
cord-006860-a3b8hyyr	4714	5	from	from	IN
cord-006860-a3b8hyyr	4714	6	complicated	complicated	JJ
cord-006860-a3b8hyyr	4714	7	joint	joint	JJ
cord-006860-a3b8hyyr	4714	8	and	and	CC
cord-006860-a3b8hyyr	4714	9	gingival	gingival	NN
cord-006860-a3b8hyyr	4714	10	bleeds	bleed	VBZ
cord-006860-a3b8hyyr	4714	11	to	to	IN
cord-006860-a3b8hyyr	4714	12	lifethreatening	lifethreatening	JJ
cord-006860-a3b8hyyr	4714	13	psoas	psoas	NN
cord-006860-a3b8hyyr	4714	14	bleeds	bleed	VBZ
cord-006860-a3b8hyyr	4714	15	,	,	,
cord-006860-a3b8hyyr	4714	16	have	have	VBP
cord-006860-a3b8hyyr	4714	17	been	be	VBN
cord-006860-a3b8hyyr	4714	18	treated	treat	VBN
cord-006860-a3b8hyyr	4714	19	.	.	.
cord-006860-a3b8hyyr	4715	1	Operations	operation	NNS
cord-006860-a3b8hyyr	4715	2	have	have	VBP
cord-006860-a3b8hyyr	4715	3	been	be	VBN
cord-006860-a3b8hyyr	4715	4	tooth	tooth	NN
cord-006860-a3b8hyyr	4715	5	extractions	extraction	NNS
cord-006860-a3b8hyyr	4715	6	,	,	,
cord-006860-a3b8hyyr	4715	7	radiosynovectomy	radiosynovectomy	NN
cord-006860-a3b8hyyr	4715	8	,	,	,
cord-006860-a3b8hyyr	4715	9	implantation	implantation	NN
cord-006860-a3b8hyyr	4715	10	and	and	CC
cord-006860-a3b8hyyr	4715	11	explantadon	explantadon	NN
cord-006860-a3b8hyyr	4715	12	of	of	IN
cord-006860-a3b8hyyr	4715	13	porth	porth	NNP
cord-006860-a3b8hyyr	4715	14	-	-	HYPH
cord-006860-a3b8hyyr	4715	15	acaths	acaths	NNP
cord-006860-a3b8hyyr	4715	16	and	and	CC
cord-006860-a3b8hyyr	4715	17	one	one	CD
cord-006860-a3b8hyyr	4715	18	adenotomy	adenotomy	NN
cord-006860-a3b8hyyr	4715	19	.	.	.
cord-006860-a3b8hyyr	4716	1	Dose	dose	JJ
cord-006860-a3b8hyyr	4716	2	regimen	regimen	NN
cord-006860-a3b8hyyr	4716	3	was	be	VBD
cord-006860-a3b8hyyr	4716	4	90	90	CD
cord-006860-a3b8hyyr	4716	5	-	-	SYM
cord-006860-a3b8hyyr	4716	6	120	120	CD
cord-006860-a3b8hyyr	4717	1	/zg	/zg	NNP
cord-006860-a3b8hyyr	4717	2	/	/	SYM
cord-006860-a3b8hyyr	4717	3	kg	kg	NNP
cord-006860-a3b8hyyr	4717	4	BW	BW	NNP
cord-006860-a3b8hyyr	4717	5	every	every	DT
cord-006860-a3b8hyyr	4717	6	two	two	CD
cord-006860-a3b8hyyr	4717	7	to	to	TO
cord-006860-a3b8hyyr	4717	8	three	three	CD
cord-006860-a3b8hyyr	4717	9	hours	hour	NNS
cord-006860-a3b8hyyr	4717	10	until	until	IN
cord-006860-a3b8hyyr	4717	11	clinical	clinical	JJ
cord-006860-a3b8hyyr	4717	12	improvement	improvement	NN
cord-006860-a3b8hyyr	4717	13	,	,	,
cord-006860-a3b8hyyr	4717	14	with	with	IN
cord-006860-a3b8hyyr	4717	15	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	4717	16	dose	dose	NN
cord-006860-a3b8hyyr	4717	17	reduction	reduction	NN
cord-006860-a3b8hyyr	4717	18	.	.	.
cord-006860-a3b8hyyr	4718	1	Results	result	NNS
cord-006860-a3b8hyyr	4718	2	:	:	:
cord-006860-a3b8hyyr	4719	1	For	for	IN
cord-006860-a3b8hyyr	4719	2	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4719	3	episodes	episode	NNS
cord-006860-a3b8hyyr	4719	4	,	,	,
cord-006860-a3b8hyyr	4719	5	response	response	NN
cord-006860-a3b8hyyr	4719	6	to	to	IN
cord-006860-a3b8hyyr	4719	7	rFVIIa	rfviia	NN
cord-006860-a3b8hyyr	4719	8	after	after	IN
cord-006860-a3b8hyyr	4719	9	24	24	CD
cord-006860-a3b8hyyr	4719	10	hours	hour	NNS
cord-006860-a3b8hyyr	4719	11	was	be	VBD
cord-006860-a3b8hyyr	4719	12	effective	effective	JJ
cord-006860-a3b8hyyr	4719	13	in	in	IN
cord-006860-a3b8hyyr	4719	14	72	72	CD
cord-006860-a3b8hyyr	4719	15	%	%	NN
cord-006860-a3b8hyyr	4719	16	,	,	,
cord-006860-a3b8hyyr	4719	17	partially	partially	RB
cord-006860-a3b8hyyr	4719	18	effective	effective	JJ
cord-006860-a3b8hyyr	4719	19	in	in	IN
cord-006860-a3b8hyyr	4719	20	12	12	CD
cord-006860-a3b8hyyr	4719	21	9"0	9"0	CD
cord-006860-a3b8hyyr	4719	22	,	,	,
cord-006860-a3b8hyyr	4719	23	ineffective	ineffective	JJ
cord-006860-a3b8hyyr	4719	24	in	in	IN
cord-006860-a3b8hyyr	4719	25	129"o	129"o	CD
cord-006860-a3b8hyyr	4719	26	and	and	CC
cord-006860-a3b8hyyr	4719	27	not	not	RB
cord-006860-a3b8hyyr	4719	28	evaluable	evaluable	JJ
cord-006860-a3b8hyyr	4719	29	in	in	IN
cord-006860-a3b8hyyr	4719	30	1	1	CD
cord-006860-a3b8hyyr	4719	31	(	(	-LRB-
cord-006860-a3b8hyyr	4719	32	4	4	CD
cord-006860-a3b8hyyr	4719	33	%	%	NN
cord-006860-a3b8hyyr	4719	34	)	)	-RRB-
cord-006860-a3b8hyyr	4719	35	of	of	IN
cord-006860-a3b8hyyr	4719	36	the	the	DT
cord-006860-a3b8hyyr	4719	37	patients	patient	NNS
cord-006860-a3b8hyyr	4719	38	.	.	.
cord-006860-a3b8hyyr	4720	1	Two	two	CD
cord-006860-a3b8hyyr	4720	2	of	of	IN
cord-006860-a3b8hyyr	4720	3	the	the	DT
cord-006860-a3b8hyyr	4720	4	three	three	CD
cord-006860-a3b8hyyr	4720	5	treatment	treatment	NN
cord-006860-a3b8hyyr	4720	6	failures	failure	NNS
cord-006860-a3b8hyyr	4720	7	were	be	VBD
cord-006860-a3b8hyyr	4720	8	associated	associate	VBN
cord-006860-a3b8hyyr	4720	9	with	with	IN
cord-006860-a3b8hyyr	4720	10	very	very	RB
cord-006860-a3b8hyyr	4720	11	long	long	JJ
cord-006860-a3b8hyyr	4720	12	dosage	dosage	NN
cord-006860-a3b8hyyr	4720	13	intervals	interval	NNS
cord-006860-a3b8hyyr	4720	14	of	of	IN
cord-006860-a3b8hyyr	4720	15	rFVIIa	rfviia	NN
cord-006860-a3b8hyyr	4720	16	.	.	.
cord-006860-a3b8hyyr	4721	1	The	the	DT
cord-006860-a3b8hyyr	4721	2	third	third	JJ
cord-006860-a3b8hyyr	4721	3	patient	patient	NN
cord-006860-a3b8hyyr	4721	4	was	be	VBD
cord-006860-a3b8hyyr	4721	5	in	in	IN
cord-006860-a3b8hyyr	4721	6	a	a	DT
cord-006860-a3b8hyyr	4721	7	critical	critical	JJ
cord-006860-a3b8hyyr	4721	8	situation	situation	NN
cord-006860-a3b8hyyr	4721	9	with	with	IN
cord-006860-a3b8hyyr	4721	10	artificial	artificial	JJ
cord-006860-a3b8hyyr	4721	11	high	high	JJ
cord-006860-a3b8hyyr	4721	12	pressure	pressure	NN
cord-006860-a3b8hyyr	4721	13	respiration	respiration	NN
cord-006860-a3b8hyyr	4721	14	and	and	CC
cord-006860-a3b8hyyr	4721	15	polytransfusion	polytransfusion	NN
cord-006860-a3b8hyyr	4721	16	because	because	IN
cord-006860-a3b8hyyr	4721	17	of	of	IN
cord-006860-a3b8hyyr	4721	18	a	a	DT
cord-006860-a3b8hyyr	4721	19	hematothorax	hematothorax	NN
cord-006860-a3b8hyyr	4721	20	,	,	,
cord-006860-a3b8hyyr	4721	21	and	and	CC
cord-006860-a3b8hyyr	4721	22	suffered	suffer	VBD
cord-006860-a3b8hyyr	4721	23	a	a	DT
cord-006860-a3b8hyyr	4721	24	terminal	terminal	JJ
cord-006860-a3b8hyyr	4721	25	intracerebral	intracerebral	JJ
cord-006860-a3b8hyyr	4721	26	bleed	bleed	NN
cord-006860-a3b8hyyr	4721	27	.	.	.
cord-006860-a3b8hyyr	4722	1	The	the	DT
cord-006860-a3b8hyyr	4722	2	efficacy	efficacy	NN
cord-006860-a3b8hyyr	4722	3	of	of	IN
cord-006860-a3b8hyyr	4722	4	rFVIIa	rfviia	NN
cord-006860-a3b8hyyr	4722	5	for	for	IN
cord-006860-a3b8hyyr	4722	6	surgery	surgery	NN
cord-006860-a3b8hyyr	4722	7	was	be	VBD
cord-006860-a3b8hyyr	4722	8	very	very	RB
cord-006860-a3b8hyyr	4722	9	good	good	JJ
cord-006860-a3b8hyyr	4722	10	.	.	.
cord-006860-a3b8hyyr	4723	1	Response	response	NN
cord-006860-a3b8hyyr	4723	2	to	to	IN
cord-006860-a3b8hyyr	4723	3	treatment	treatment	NN
cord-006860-a3b8hyyr	4723	4	was	be	VBD
cord-006860-a3b8hyyr	4723	5	independent	independent	JJ
cord-006860-a3b8hyyr	4723	6	of	of	IN
cord-006860-a3b8hyyr	4723	7	antibody	antibody	NN
cord-006860-a3b8hyyr	4723	8	titer	titer	NN
cord-006860-a3b8hyyr	4723	9	.	.	.
cord-006860-a3b8hyyr	4724	1	No	no	DT
cord-006860-a3b8hyyr	4724	2	signs	sign	NNS
cord-006860-a3b8hyyr	4724	3	of	of	IN
cord-006860-a3b8hyyr	4724	4	DIC	DIC	NNP
cord-006860-a3b8hyyr	4724	5	or	or	CC
cord-006860-a3b8hyyr	4724	6	activation	activation	NN
cord-006860-a3b8hyyr	4724	7	of	of	IN
cord-006860-a3b8hyyr	4724	8	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4724	9	were	be	VBD
cord-006860-a3b8hyyr	4724	10	noted	note	VBN
cord-006860-a3b8hyyr	4724	11	.	.	.
cord-006860-a3b8hyyr	4725	1	Conduslon	Conduslon	NNP
cord-006860-a3b8hyyr	4725	2	:	:	:
cord-006860-a3b8hyyr	4726	1	In	in	IN
cord-006860-a3b8hyyr	4726	2	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4726	3	experience	experience	NN
cord-006860-a3b8hyyr	4726	4	,	,	,
cord-006860-a3b8hyyr	4726	5	rFVIIa	rfviia	NN
cord-006860-a3b8hyyr	4726	6	is	be	VBZ
cord-006860-a3b8hyyr	4726	7	an	an	DT
cord-006860-a3b8hyyr	4726	8	efficient	efficient	JJ
cord-006860-a3b8hyyr	4726	9	and	and	CC
cord-006860-a3b8hyyr	4726	10	safe	safe	JJ
cord-006860-a3b8hyyr	4726	11	treatment	treatment	NN
cord-006860-a3b8hyyr	4726	12	for	for	IN
cord-006860-a3b8hyyr	4726	13	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4726	14	patients	patient	NNS
cord-006860-a3b8hyyr	4726	15	with	with	IN
cord-006860-a3b8hyyr	4726	16	acute	acute	JJ
cord-006860-a3b8hyyr	4726	17	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4726	18	episodes	episode	NNS
cord-006860-a3b8hyyr	4726	19	.	.	.
cord-006860-a3b8hyyr	4727	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	4727	2	should	should	MD
cord-006860-a3b8hyyr	4727	3	be	be	VB
cord-006860-a3b8hyyr	4727	4	investigated	investigate	VBN
cord-006860-a3b8hyyr	4727	5	,	,	,
cord-006860-a3b8hyyr	4727	6	whether	whether	IN
cord-006860-a3b8hyyr	4727	7	rFVIIa	rfviia	NN
cord-006860-a3b8hyyr	4727	8	can	can	MD
cord-006860-a3b8hyyr	4727	9	be	be	VB
cord-006860-a3b8hyyr	4727	10	an	an	DT
cord-006860-a3b8hyyr	4727	11	alternative	alternative	JJ
cord-006860-a3b8hyyr	4727	12	treatment	treatment	NN
cord-006860-a3b8hyyr	4727	13	also	also	RB
cord-006860-a3b8hyyr	4727	14	for	for	IN
cord-006860-a3b8hyyr	4727	15	the	the	DT
cord-006860-a3b8hyyr	4727	16	hometreatment	hometreatment	NN
cord-006860-a3b8hyyr	4727	17	situation	situation	NN
cord-006860-a3b8hyyr	4727	18	.	.	.
cord-006860-a3b8hyyr	4728	1	SUCCESSFUL	successful	JJ
cord-006860-a3b8hyyr	4728	2	IMMUNETOLERANCE	IMMUNETOLERANCE	NNP
cord-006860-a3b8hyyr	4728	3	THERAPY	therapy	NN
cord-006860-a3b8hyyr	4728	4	OF	of	IN
cord-006860-a3b8hyyr	4728	5	F	F	NNP
cord-006860-a3b8hyyr	4728	6	VIH	VIH	NNP
cord-006860-a3b8hyyr	4728	7	-	-	HYPH
cord-006860-a3b8hyyr	4728	8	INHIBITOR	INHIBITOR	NNP
cord-006860-a3b8hyyr	4728	9	IN	in	IN
cord-006860-a3b8hyyr	4728	10	CHILDREN	child	NNS
cord-006860-a3b8hyyr	4728	11	AFTER	after	IN
cord-006860-a3b8hyyr	4728	12	CHANGING	change	VBG
cord-006860-a3b8hyyr	4728	13	FROM	from	IN
cord-006860-a3b8hyyr	4728	14	HIGH	high	JJ
cord-006860-a3b8hyyr	4728	15	TO	to	IN
cord-006860-a3b8hyyr	4728	16	INTERMEDIATE	intermediate	JJ
cord-006860-a3b8hyyr	4728	17	PURITY	purity	NN
cord-006860-a3b8hyyr	4728	18	F	F	NNP
cord-006860-a3b8hyyr	4728	19	VIH	VIH	NNP
cord-006860-a3b8hyyr	4729	1	CONCENTRATE	CONCENTRATE	NNP
cord-006860-a3b8hyyr	4729	2	W.	W.	NNP
cord-006860-a3b8hyyr	4729	3	Kreuz	Kreuz	NNP
cord-006860-a3b8hyyr	4729	4	,	,	,
cord-006860-a3b8hyyr	4729	5	J.	J.	NNP
cord-006860-a3b8hyyr	4729	6	Joseph-$teiner	joseph-$teiner	NN
cord-006860-a3b8hyyr	4729	7	,	,	,
cord-006860-a3b8hyyr	4729	8	D.	D.	NNP
cord-006860-a3b8hyyr	4729	9	Mentzer	Mentzer	NNP
cord-006860-a3b8hyyr	4729	10	,	,	,
cord-006860-a3b8hyyr	4729	11	G.	G.	NNP
cord-006860-a3b8hyyr	4729	12	Auerswald	Auerswald	NNP
cord-006860-a3b8hyyr	4729	13	*	*	NFP
cord-006860-a3b8hyyr	4730	1	,	,	,
cord-006860-a3b8hyyr	4730	2	T.	T.	NNP
cord-006860-a3b8hyyr	4730	3	Beeg	Beeg	NNP
cord-006860-a3b8hyyr	4730	4	,	,	,
cord-006860-a3b8hyyr	4730	5	S.	S.	NNP
cord-006860-a3b8hyyr	4730	6	Becker	Becker	NNP
cord-006860-a3b8hyyr	4730	7	Zentrum	Zentrum	NNP
cord-006860-a3b8hyyr	4730	8	der	der	NNP
cord-006860-a3b8hyyr	4730	9	Kinderheilkunde	Kinderheilkunde	NNP
cord-006860-a3b8hyyr	4730	10	,	,	,
cord-006860-a3b8hyyr	4730	11	J.	J.	NNP
cord-006860-a3b8hyyr	4730	12	W.	W.	NNP
cord-006860-a3b8hyyr	4730	13	Goethe	Goethe	NNP
cord-006860-a3b8hyyr	4730	14	-	-	HYPH
cord-006860-a3b8hyyr	4730	15	Universit~	Universit~	NNP
cord-006860-a3b8hyyr	4731	1	itj	itj	NNP
cord-006860-a3b8hyyr	4731	2	Frankfurt	Frankfurt	NNP
cord-006860-a3b8hyyr	4731	3	am	be	VBP
cord-006860-a3b8hyyr	4731	4	Main	Main	NNP
cord-006860-a3b8hyyr	4732	1	*	*	NFP
cord-006860-a3b8hyyr	4732	2	Professor	Professor	NNP
cord-006860-a3b8hyyr	4732	3	Hess	Hess	NNP
cord-006860-a3b8hyyr	4732	4	Kinderklinik	Kinderklinik	NNP
cord-006860-a3b8hyyr	4732	5	Bremen	Bremen	NNP
cord-006860-a3b8hyyr	4732	6	Introduction	introduction	NN
cord-006860-a3b8hyyr	4732	7	:	:	:
cord-006860-a3b8hyyr	4733	1	Inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4733	2	to	to	IN
cord-006860-a3b8hyyr	4733	3	F	F	NNP
cord-006860-a3b8hyyr	4733	4	VIII	VIII	NNP
cord-006860-a3b8hyyr	4733	5	is	be	VBZ
cord-006860-a3b8hyyr	4733	6	the	the	DT
cord-006860-a3b8hyyr	4733	7	most	most	RBS
cord-006860-a3b8hyyr	4733	8	severe	severe	JJ
cord-006860-a3b8hyyr	4733	9	complication	complication	NN
cord-006860-a3b8hyyr	4733	10	in	in	IN
cord-006860-a3b8hyyr	4733	11	treatment	treatment	NN
cord-006860-a3b8hyyr	4733	12	of	of	IN
cord-006860-a3b8hyyr	4733	13	patients	patient	NNS
cord-006860-a3b8hyyr	4733	14	with	with	IN
cord-006860-a3b8hyyr	4733	15	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	4733	16	A.	a.	NN
cord-006860-a3b8hyyr	4734	1	The	the	DT
cord-006860-a3b8hyyr	4734	2	incidence	incidence	NN
cord-006860-a3b8hyyr	4734	3	of	of	IN
cord-006860-a3b8hyyr	4734	4	F	F	NNP
cord-006860-a3b8hyyr	4734	5	VIII	VIII	NNP
cord-006860-a3b8hyyr	4734	6	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	4734	7	is	be	VBZ
cord-006860-a3b8hyyr	4734	8	estimated	estimate	VBN
cord-006860-a3b8hyyr	4734	9	to	to	TO
cord-006860-a3b8hyyr	4734	10	range	range	VB
cord-006860-a3b8hyyr	4734	11	between	between	IN
cord-006860-a3b8hyyr	4734	12	15	15	CD
cord-006860-a3b8hyyr	4734	13	-	-	SYM
cord-006860-a3b8hyyr	4734	14	33	33	CD
cord-006860-a3b8hyyr	4734	15	%	%	NN
cord-006860-a3b8hyyr	4734	16	.	.	.
cord-006860-a3b8hyyr	4735	1	Several	several	JJ
cord-006860-a3b8hyyr	4735	2	authors	author	NNS
cord-006860-a3b8hyyr	4735	3	reported	report	VBD
cord-006860-a3b8hyyr	4735	4	that	that	IN
cord-006860-a3b8hyyr	4735	5	the	the	DT
cord-006860-a3b8hyyr	4735	6	immunetolerance	immunetolerance	NN
cord-006860-a3b8hyyr	4735	7	therapy	therapy	NN
cord-006860-a3b8hyyr	4735	8	(	(	-LRB-
cord-006860-a3b8hyyr	4735	9	ITr	ITr	NNP
cord-006860-a3b8hyyr	4735	10	)	)	-RRB-
cord-006860-a3b8hyyr	4735	11	of	of	IN
cord-006860-a3b8hyyr	4735	12	F	F	NNP
cord-006860-a3b8hyyr	4735	13	VIII	VIII	NNP
cord-006860-a3b8hyyr	4735	14	-	-	HYPH
cord-006860-a3b8hyyr	4735	15	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	4735	16	can	can	MD
cord-006860-a3b8hyyr	4735	17	be	be	VB
cord-006860-a3b8hyyr	4735	18	induced	induce	VBN
cord-006860-a3b8hyyr	4735	19	with	with	IN
cord-006860-a3b8hyyr	4735	20	high	high	JJ
cord-006860-a3b8hyyr	4735	21	dose	dose	NN
cord-006860-a3b8hyyr	4735	22	F	F	NNP
cord-006860-a3b8hyyr	4735	23	VIII	VIII	NNP
cord-006860-a3b8hyyr	4735	24	concentrate	concentrate	VBP
cord-006860-a3b8hyyr	4735	25	.	.	.
cord-006860-a3b8hyyr	4736	1	Objective	objective	NN
cord-006860-a3b8hyyr	4736	2	:	:	:
cord-006860-a3b8hyyr	4737	1	This	this	DT
cord-006860-a3b8hyyr	4737	2	presentation	presentation	NN
cord-006860-a3b8hyyr	4737	3	will	will	MD
cord-006860-a3b8hyyr	4737	4	show	show	VB
cord-006860-a3b8hyyr	4737	5	data	datum	NNS
cord-006860-a3b8hyyr	4737	6	of	of	IN
cord-006860-a3b8hyyr	4737	7	four	four	CD
cord-006860-a3b8hyyr	4737	8	children	child	NNS
cord-006860-a3b8hyyr	4737	9	with	with	IN
cord-006860-a3b8hyyr	4737	10	haemophilia	haemophilia	NN
cord-006860-a3b8hyyr	4737	11	A	A	NNP
cord-006860-a3b8hyyr	4737	12	and	and	CC
cord-006860-a3b8hyyr	4737	13	F	F	NNP
cord-006860-a3b8hyyr	4737	14	VIII	VIII	NNP
cord-006860-a3b8hyyr	4737	15	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4737	16	(	(	-LRB-
cord-006860-a3b8hyyr	4737	17	high	high	JJ
cord-006860-a3b8hyyr	4737	18	responder	responder	NN
cord-006860-a3b8hyyr	4737	19	)	)	-RRB-
cord-006860-a3b8hyyr	4737	20	,	,	,
cord-006860-a3b8hyyr	4737	21	who	who	WP
cord-006860-a3b8hyyr	4737	22	had	have	VBD
cord-006860-a3b8hyyr	4737	23	an	an	DT
cord-006860-a3b8hyyr	4737	24	unsuccessful	unsuccessful	JJ
cord-006860-a3b8hyyr	4737	25	lit	lit	NN
cord-006860-a3b8hyyr	4737	26	with	with	IN
cord-006860-a3b8hyyr	4737	27	high	high	JJ
cord-006860-a3b8hyyr	4737	28	dose	dose	NN
cord-006860-a3b8hyyr	4737	29	F	F	NNP
cord-006860-a3b8hyyr	4737	30	VIII	VIII	NNP
cord-006860-a3b8hyyr	4737	31	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4737	32	(	(	-LRB-
cord-006860-a3b8hyyr	4737	33	high	high	JJ
cord-006860-a3b8hyyr	4737	34	purity	purity	NN
cord-006860-a3b8hyyr	4737	35	)	)	-RRB-
cord-006860-a3b8hyyr	4737	36	in	in	IN
cord-006860-a3b8hyyr	4737	37	the	the	DT
cord-006860-a3b8hyyr	4737	38	first	first	JJ
cord-006860-a3b8hyyr	4737	39	step	step	NN
cord-006860-a3b8hyyr	4737	40	.	.	.
cord-006860-a3b8hyyr	4738	1	F	F	NNP
cord-006860-a3b8hyyr	4738	2	VIII	VIII	NNP
cord-006860-a3b8hyyr	4738	3	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4738	4	was	be	VBD
cord-006860-a3b8hyyr	4738	5	changed	change	VBN
cord-006860-a3b8hyyr	4738	6	to	to	IN
cord-006860-a3b8hyyr	4738	7	an	an	DT
cord-006860-a3b8hyyr	4738	8	intermediate	intermediate	JJ
cord-006860-a3b8hyyr	4738	9	purity	purity	NN
cord-006860-a3b8hyyr	4738	10	product	product	NN
cord-006860-a3b8hyyr	4738	11	(	(	-LRB-
cord-006860-a3b8hyyr	4738	12	Haemate	Haemate	NNP
cord-006860-a3b8hyyr	4738	13	HS	HS	NNP
cord-006860-a3b8hyyr	4738	14	®	®	POS
cord-006860-a3b8hyyr	4738	15	)	)	-RRB-
cord-006860-a3b8hyyr	4738	16	in	in	IN
cord-006860-a3b8hyyr	4738	17	the	the	DT
cord-006860-a3b8hyyr	4738	18	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	4738	19	course	course	NN
cord-006860-a3b8hyyr	4738	20	of	of	IN
cord-006860-a3b8hyyr	4738	21	H'T.	H'T.	NNP
cord-006860-a3b8hyyr	4739	1	All	all	DT
cord-006860-a3b8hyyr	4739	2	patients	patient	NNS
cord-006860-a3b8hyyr	4739	3	received	receive	VBD
cord-006860-a3b8hyyr	4739	4	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4739	5	prophylaxis	prophylaxis	NN
cord-006860-a3b8hyyr	4739	6	with	with	IN
cord-006860-a3b8hyyr	4739	7	an	an	DT
cord-006860-a3b8hyyr	4739	8	activated	activate	VBN
cord-006860-a3b8hyyr	4739	9	-	-	HYPH
cord-006860-a3b8hyyr	4739	10	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4739	11	-	-	HYPH
cord-006860-a3b8hyyr	4739	12	complex	complex	NN
cord-006860-a3b8hyyr	4739	13	-	-	HYPH
cord-006860-a3b8hyyr	4739	14	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4739	15	(	(	-LRB-
cord-006860-a3b8hyyr	4739	16	FEIBA	FEIBA	NNP
cord-006860-a3b8hyyr	4739	17	®	®	NNP
cord-006860-a3b8hyyr	4739	18	)	)	-RRB-
cord-006860-a3b8hyyr	4739	19	.	.	.
cord-006860-a3b8hyyr	4740	1	Results	result	NNS
cord-006860-a3b8hyyr	4740	2	:	:	:
cord-006860-a3b8hyyr	4741	1	Median	median	JJ
cord-006860-a3b8hyyr	4741	2	age	age	NN
cord-006860-a3b8hyyr	4741	3	was	be	VBD
cord-006860-a3b8hyyr	4741	4	13	13	CD
cord-006860-a3b8hyyr	4741	5	(	(	-LRB-
cord-006860-a3b8hyyr	4741	6	9	9	CD
cord-006860-a3b8hyyr	4741	7	-	-	SYM
cord-006860-a3b8hyyr	4741	8	18	18	CD
cord-006860-a3b8hyyr	4741	9	)	)	-RRB-
cord-006860-a3b8hyyr	4741	10	months	month	NNS
cord-006860-a3b8hyyr	4741	11	,	,	,
cord-006860-a3b8hyyr	4741	12	when	when	WRB
cord-006860-a3b8hyyr	4741	13	the	the	DT
cord-006860-a3b8hyyr	4741	14	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4741	15	was	be	VBD
cord-006860-a3b8hyyr	4741	16	first	first	RB
cord-006860-a3b8hyyr	4741	17	detected	detect	VBN
cord-006860-a3b8hyyr	4741	18	.	.	.
cord-006860-a3b8hyyr	4742	1	In	in	IN
cord-006860-a3b8hyyr	4742	2	all	all	DT
cord-006860-a3b8hyyr	4742	3	four	four	CD
cord-006860-a3b8hyyr	4742	4	patients	patient	NNS
cord-006860-a3b8hyyr	4742	5	the	the	DT
cord-006860-a3b8hyyr	4742	6	F	F	NNP
cord-006860-a3b8hyyr	4742	7	VIII	VIII	NNP
cord-006860-a3b8hyyr	4742	8	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4742	9	titre	titre	NN
cord-006860-a3b8hyyr	4742	10	increased	increase	VBD
cord-006860-a3b8hyyr	4742	11	under	under	IN
cord-006860-a3b8hyyr	4742	12	immunetolerance	immunetolerance	NN
cord-006860-a3b8hyyr	4742	13	treatment	treatment	NN
cord-006860-a3b8hyyr	4742	14	with	with	IN
cord-006860-a3b8hyyr	4742	15	F	F	NNP
cord-006860-a3b8hyyr	4742	16	VIII	VIII	NNP
cord-006860-a3b8hyyr	4742	17	concentrate	concentrate	VBP
cord-006860-a3b8hyyr	4742	18	(	(	-LRB-
cord-006860-a3b8hyyr	4742	19	high	high	JJ
cord-006860-a3b8hyyr	4742	20	purity	purity	NN
cord-006860-a3b8hyyr	4742	21	)	)	-RRB-
cord-006860-a3b8hyyr	4742	22	in	in	IN
cord-006860-a3b8hyyr	4742	23	the	the	DT
cord-006860-a3b8hyyr	4742	24	first	first	JJ
cord-006860-a3b8hyyr	4742	25	step	step	NN
cord-006860-a3b8hyyr	4742	26	of	of	IN
cord-006860-a3b8hyyr	4742	27	therapy	therapy	NN
cord-006860-a3b8hyyr	4742	28	.	.	.
cord-006860-a3b8hyyr	4743	1	After	after	IN
cord-006860-a3b8hyyr	4743	2	changing	change	VBG
cord-006860-a3b8hyyr	4743	3	the	the	DT
cord-006860-a3b8hyyr	4743	4	F	F	NNP
cord-006860-a3b8hyyr	4743	5	VIII	VIII	NNP
cord-006860-a3b8hyyr	4743	6	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4743	7	(	(	-LRB-
cord-006860-a3b8hyyr	4743	8	intermediate	intermediate	JJ
cord-006860-a3b8hyyr	4743	9	purity	purity	NN
cord-006860-a3b8hyyr	4743	10	)	)	-RRB-
cord-006860-a3b8hyyr	4744	1	the	the	DT
cord-006860-a3b8hyyr	4744	2	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4744	3	titres	titre	NNS
cord-006860-a3b8hyyr	4744	4	decreased	decrease	VBD
cord-006860-a3b8hyyr	4744	5	continuously	continuously	RB
cord-006860-a3b8hyyr	4744	6	after	after	IN
cord-006860-a3b8hyyr	4744	7	a	a	DT
cord-006860-a3b8hyyr	4744	8	rebooster	rebooster	NN
cord-006860-a3b8hyyr	4744	9	effect	effect	NN
cord-006860-a3b8hyyr	4744	10	to	to	IN
cord-006860-a3b8hyyr	4744	11	0BE	0be	CD
cord-006860-a3b8hyyr	4744	12	within	within	IN
cord-006860-a3b8hyyr	4744	13	months	month	NNS
cord-006860-a3b8hyyr	4744	14	.	.	.
cord-006860-a3b8hyyr	4745	1	Median	median	JJ
cord-006860-a3b8hyyr	4745	2	duration	duration	NN
cord-006860-a3b8hyyr	4745	3	of	of	IN
cord-006860-a3b8hyyr	4745	4	F	F	NNP
cord-006860-a3b8hyyr	4745	5	VIII	VIII	NNP
cord-006860-a3b8hyyr	4745	6	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4745	7	elimination	elimination	NN
cord-006860-a3b8hyyr	4745	8	time	time	NN
cord-006860-a3b8hyyr	4745	9	(	(	-LRB-
cord-006860-a3b8hyyr	4745	10	until	until	IN
cord-006860-a3b8hyyr	4745	11	first	first	JJ
cord-006860-a3b8hyyr	4745	12	testing	testing	NN
cord-006860-a3b8hyyr	4745	13	of	of	IN
cord-006860-a3b8hyyr	4745	14	0	0	CD
cord-006860-a3b8hyyr	4745	15	BE	be	NN
cord-006860-a3b8hyyr	4745	16	)	)	-RRB-
cord-006860-a3b8hyyr	4745	17	was	be	VBD
cord-006860-a3b8hyyr	4745	18	3	3	CD
cord-006860-a3b8hyyr	4745	19	(	(	-LRB-
cord-006860-a3b8hyyr	4745	20	2	2	CD
cord-006860-a3b8hyyr	4745	21	-	-	SYM
cord-006860-a3b8hyyr	4745	22	5	5	CD
cord-006860-a3b8hyyr	4745	23	)	)	-RRB-
cord-006860-a3b8hyyr	4745	24	months	month	NNS
cord-006860-a3b8hyyr	4745	25	.	.	.
cord-006860-a3b8hyyr	4746	1	In	in	IN
cord-006860-a3b8hyyr	4746	2	all	all	DT
cord-006860-a3b8hyyr	4746	3	patients	patient	NNS
cord-006860-a3b8hyyr	4746	4	the	the	DT
cord-006860-a3b8hyyr	4746	5	F	F	NNP
cord-006860-a3b8hyyr	4746	6	VIII	VIII	NNP
cord-006860-a3b8hyyr	4746	7	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4746	8	was	be	VBD
cord-006860-a3b8hyyr	4746	9	successfully	successfully	RB
cord-006860-a3b8hyyr	4746	10	eliminated	eliminate	VBN
cord-006860-a3b8hyyr	4746	11	.	.	.
cord-006860-a3b8hyyr	4747	1	Until	until	IN
cord-006860-a3b8hyyr	4747	2	now	now	RB
cord-006860-a3b8hyyr	4747	3	all	all	DT
cord-006860-a3b8hyyr	4747	4	patients	patient	NNS
cord-006860-a3b8hyyr	4747	5	are	be	VBP
cord-006860-a3b8hyyr	4747	6	under	under	IN
cord-006860-a3b8hyyr	4747	7	prophylactic	prophylactic	JJ
cord-006860-a3b8hyyr	4747	8	treatment	treatment	NN
cord-006860-a3b8hyyr	4747	9	with	with	IN
cord-006860-a3b8hyyr	4747	10	F	F	NNP
cord-006860-a3b8hyyr	4747	11	VIII	VIII	NNP
cord-006860-a3b8hyyr	4747	12	concentrate	concentrate	VBP
cord-006860-a3b8hyyr	4747	13	and	and	CC
cord-006860-a3b8hyyr	4747	14	had	have	VBD
cord-006860-a3b8hyyr	4747	15	no	no	DT
cord-006860-a3b8hyyr	4747	16	positive	positive	JJ
cord-006860-a3b8hyyr	4747	17	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4747	18	testing	testing	NN
cord-006860-a3b8hyyr	4747	19	since	since	IN
cord-006860-a3b8hyyr	4747	20	.	.	.
cord-006860-a3b8hyyr	4748	1	Median	median	JJ
cord-006860-a3b8hyyr	4748	2	observation	observation	NN
cord-006860-a3b8hyyr	4748	3	time	time	NN
cord-006860-a3b8hyyr	4748	4	since	since	IN
cord-006860-a3b8hyyr	4748	5	the	the	DT
cord-006860-a3b8hyyr	4748	6	first	first	JJ
cord-006860-a3b8hyyr	4748	7	testing	testing	NN
cord-006860-a3b8hyyr	4748	8	of	of	IN
cord-006860-a3b8hyyr	4748	9	0	0	CD
cord-006860-a3b8hyyr	4748	10	BE	be	NN
cord-006860-a3b8hyyr	4748	11	is	be	VBZ
cord-006860-a3b8hyyr	4748	12	14	14	CD
cord-006860-a3b8hyyr	4748	13	(	(	-LRB-
cord-006860-a3b8hyyr	4748	14	4	4	CD
cord-006860-a3b8hyyr	4748	15	-	-	SYM
cord-006860-a3b8hyyr	4748	16	60	60	CD
cord-006860-a3b8hyyr	4748	17	)	)	-RRB-
cord-006860-a3b8hyyr	4748	18	months	month	NNS
cord-006860-a3b8hyyr	4748	19	.	.	.
cord-006860-a3b8hyyr	4749	1	Conclusion	conclusion	NN
cord-006860-a3b8hyyr	4749	2	:	:	:
cord-006860-a3b8hyyr	4750	1	Different	different	JJ
cord-006860-a3b8hyyr	4750	2	studies	study	NNS
cord-006860-a3b8hyyr	4750	3	concerning	concern	VBG
cord-006860-a3b8hyyr	4750	4	immunetolerance	immunetolerance	NN
cord-006860-a3b8hyyr	4750	5	treatment	treatment	NN
cord-006860-a3b8hyyr	4750	6	have	have	VBP
cord-006860-a3b8hyyr	4750	7	been	be	VBN
cord-006860-a3b8hyyr	4750	8	successful	successful	JJ
cord-006860-a3b8hyyr	4750	9	with	with	IN
cord-006860-a3b8hyyr	4750	10	F	F	NNP
cord-006860-a3b8hyyr	4750	11	VIII	VIII	NNP
cord-006860-a3b8hyyr	4750	12	concentrates	concentrate	VBZ
cord-006860-a3b8hyyr	4750	13	of	of	IN
cord-006860-a3b8hyyr	4750	14	different	different	JJ
cord-006860-a3b8hyyr	4750	15	purity	purity	NN
cord-006860-a3b8hyyr	4750	16	.	.	.
cord-006860-a3b8hyyr	4751	1	According	accord	VBG
cord-006860-a3b8hyyr	4751	2	to	to	IN
cord-006860-a3b8hyyr	4751	3	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4751	4	experience	experience	NN
cord-006860-a3b8hyyr	4751	5	in	in	IN
cord-006860-a3b8hyyr	4751	6	these	these	DT
cord-006860-a3b8hyyr	4751	7	four	four	CD
cord-006860-a3b8hyyr	4751	8	presented	present	VBN
cord-006860-a3b8hyyr	4751	9	patients	patient	NNS
cord-006860-a3b8hyyr	4751	10	,	,	,
cord-006860-a3b8hyyr	4751	11	we	-PRON-	PRP
cord-006860-a3b8hyyr	4751	12	assume	assume	VBP
cord-006860-a3b8hyyr	4751	13	that	that	IN
cord-006860-a3b8hyyr	4751	14	probably	probably	RB
cord-006860-a3b8hyyr	4751	15	not	not	RB
cord-006860-a3b8hyyr	4751	16	the	the	DT
cord-006860-a3b8hyyr	4751	17	purity	purity	NN
cord-006860-a3b8hyyr	4751	18	of	of	IN
cord-006860-a3b8hyyr	4751	19	the	the	DT
cord-006860-a3b8hyyr	4751	20	F	F	NNP
cord-006860-a3b8hyyr	4751	21	VIII	VIII	NNP
cord-006860-a3b8hyyr	4751	22	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4751	23	is	be	VBZ
cord-006860-a3b8hyyr	4751	24	important	important	JJ
cord-006860-a3b8hyyr	4751	25	for	for	IN
cord-006860-a3b8hyyr	4751	26	the	the	DT
cord-006860-a3b8hyyr	4751	27	induction	induction	NN
cord-006860-a3b8hyyr	4751	28	of	of	IN
cord-006860-a3b8hyyr	4751	29	immunetoleranee	immunetoleranee	NNP
cord-006860-a3b8hyyr	4751	30	,	,	,
cord-006860-a3b8hyyr	4751	31	rather	rather	RB
cord-006860-a3b8hyyr	4751	32	than	than	IN
cord-006860-a3b8hyyr	4751	33	the	the	DT
cord-006860-a3b8hyyr	4751	34	type	type	NN
cord-006860-a3b8hyyr	4751	35	of	of	IN
cord-006860-a3b8hyyr	4751	36	F	F	NNP
cord-006860-a3b8hyyr	4751	37	VIII	VIII	NNP
cord-006860-a3b8hyyr	4751	38	presentation	presentation	NN
cord-006860-a3b8hyyr	4751	39	in	in	IN
cord-006860-a3b8hyyr	4751	40	the	the	DT
cord-006860-a3b8hyyr	4751	41	used	use	VBN
cord-006860-a3b8hyyr	4751	42	concentrate	concentrate	NN
cord-006860-a3b8hyyr	4751	43	.	.	.
cord-006860-a3b8hyyr	4752	1	The	the	DT
cord-006860-a3b8hyyr	4752	2	used	used	JJ
cord-006860-a3b8hyyr	4752	3	preparation	preparation	NN
cord-006860-a3b8hyyr	4752	4	(	(	-LRB-
cord-006860-a3b8hyyr	4752	5	Haemate	Haemate	NNP
cord-006860-a3b8hyyr	4752	6	HS	HS	NNP
cord-006860-a3b8hyyr	4752	7	®	®	.
cord-006860-a3b8hyyr	4752	8	)	)	-RRB-
cord-006860-a3b8hyyr	4752	9	is	be	VBZ
cord-006860-a3b8hyyr	4752	10	a	a	DT
cord-006860-a3b8hyyr	4752	11	F	F	NNP
cord-006860-a3b8hyyr	4752	12	VIII	VIII	NNP
cord-006860-a3b8hyyr	4752	13	concentrate	concentrate	VBP
cord-006860-a3b8hyyr	4752	14	with	with	IN
cord-006860-a3b8hyyr	4752	15	high	high	JJ
cord-006860-a3b8hyyr	4752	16	concentration	concentration	NN
cord-006860-a3b8hyyr	4752	17	of	of	IN
cord-006860-a3b8hyyr	4752	18	vWF	vwf	NN
cord-006860-a3b8hyyr	4752	19	,	,	,
cord-006860-a3b8hyyr	4752	20	which	which	WDT
cord-006860-a3b8hyyr	4752	21	is	be	VBZ
cord-006860-a3b8hyyr	4752	22	known	know	VBN
cord-006860-a3b8hyyr	4752	23	to	to	TO
cord-006860-a3b8hyyr	4752	24	be	be	VB
cord-006860-a3b8hyyr	4752	25	important	important	JJ
cord-006860-a3b8hyyr	4752	26	for	for	IN
cord-006860-a3b8hyyr	4752	27	the	the	DT
cord-006860-a3b8hyyr	4752	28	protection	protection	NN
cord-006860-a3b8hyyr	4752	29	of	of	IN
cord-006860-a3b8hyyr	4752	30	F	F	NNP
cord-006860-a3b8hyyr	4752	31	VIII	VIII	NNP
cord-006860-a3b8hyyr	4752	32	against	against	IN
cord-006860-a3b8hyyr	4752	33	degradation	degradation	NN
cord-006860-a3b8hyyr	4752	34	by	by	IN
cord-006860-a3b8hyyr	4752	35	proteases	protease	NNS
cord-006860-a3b8hyyr	4752	36	.	.	.
cord-006860-a3b8hyyr	4753	1	This	this	DT
cord-006860-a3b8hyyr	4753	2	may	may	MD
cord-006860-a3b8hyyr	4753	3	be	be	VB
cord-006860-a3b8hyyr	4753	4	a	a	DT
cord-006860-a3b8hyyr	4753	5	mechanism	mechanism	NN
cord-006860-a3b8hyyr	4753	6	for	for	IN
cord-006860-a3b8hyyr	4753	7	a	a	DT
cord-006860-a3b8hyyr	4753	8	prolonged	prolong	VBN
cord-006860-a3b8hyyr	4753	9	antigen	antigen	NN
cord-006860-a3b8hyyr	4753	10	presentation	presentation	NN
cord-006860-a3b8hyyr	4753	11	to	to	IN
cord-006860-a3b8hyyr	4753	12	the	the	DT
cord-006860-a3b8hyyr	4753	13	immunesystem	immunesystem	NNP
cord-006860-a3b8hyyr	4753	14	and	and	CC
cord-006860-a3b8hyyr	4753	15	thus	thus	RB
cord-006860-a3b8hyyr	4753	16	may	may	MD
cord-006860-a3b8hyyr	4753	17	have	have	VB
cord-006860-a3b8hyyr	4753	18	a	a	DT
cord-006860-a3b8hyyr	4753	19	positive	positive	JJ
cord-006860-a3b8hyyr	4753	20	impact	impact	NN
cord-006860-a3b8hyyr	4753	21	on	on	IN
cord-006860-a3b8hyyr	4753	22	the	the	DT
cord-006860-a3b8hyyr	4753	23	outcome	outcome	NN
cord-006860-a3b8hyyr	4753	24	ot	ot	VBP
cord-006860-a3b8hyyr	4753	25	ITr	itr	RB
cord-006860-a3b8hyyr	4753	26	.	.	.
cord-006860-a3b8hyyr	4754	1	Long	long	JJ
cord-006860-a3b8hyyr	4754	2	scale	scale	NN
cord-006860-a3b8hyyr	4754	3	trials	trial	NNS
cord-006860-a3b8hyyr	4754	4	are	be	VBP
cord-006860-a3b8hyyr	4754	5	needed	need	VBN
cord-006860-a3b8hyyr	4754	6	to	to	TO
cord-006860-a3b8hyyr	4754	7	prove	prove	VB
cord-006860-a3b8hyyr	4754	8	the	the	DT
cord-006860-a3b8hyyr	4754	9	above	above	JJ
cord-006860-a3b8hyyr	4754	10	assumptions	assumption	NNS
cord-006860-a3b8hyyr	4754	11	.	.	.
cord-006860-a3b8hyyr	4755	1	Thrombasthenia	Thrombasthenia	NNP
cord-006860-a3b8hyyr	4755	2	Glanzmann	Glanzmann	NNP
cord-006860-a3b8hyyr	4755	3	is	be	VBZ
cord-006860-a3b8hyyr	4755	4	a	a	DT
cord-006860-a3b8hyyr	4755	5	disease	disease	NN
cord-006860-a3b8hyyr	4755	6	affecting	affect	VBG
cord-006860-a3b8hyyr	4755	7	platelet	platelet	NN
cord-006860-a3b8hyyr	4755	8	function	function	NN
cord-006860-a3b8hyyr	4755	9	because	because	IN
cord-006860-a3b8hyyr	4755	10	of	of	IN
cord-006860-a3b8hyyr	4755	11	a	a	DT
cord-006860-a3b8hyyr	4755	12	partial	partial	JJ
cord-006860-a3b8hyyr	4755	13	or	or	CC
cord-006860-a3b8hyyr	4755	14	total	total	JJ
cord-006860-a3b8hyyr	4755	15	lack	lack	NN
cord-006860-a3b8hyyr	4755	16	of	of	IN
cord-006860-a3b8hyyr	4755	17	glycoprotein	glycoprotein	NN
cord-006860-a3b8hyyr	4755	18	(	(	-LRB-
cord-006860-a3b8hyyr	4755	19	GP	GP	NNP
cord-006860-a3b8hyyr	4755	20	)	)	-RRB-
cord-006860-a3b8hyyr	4755	21	Ilbllla	Ilbllla	NNP
cord-006860-a3b8hyyr	4755	22	expression	expression	NN
cord-006860-a3b8hyyr	4755	23	or	or	CC
cord-006860-a3b8hyyr	4755	24	a	a	DT
cord-006860-a3b8hyyr	4755	25	modification	modification	NN
cord-006860-a3b8hyyr	4755	26	of	of	IN
cord-006860-a3b8hyyr	4755	27	this	this	DT
cord-006860-a3b8hyyr	4755	28	complex	complex	NN
cord-006860-a3b8hyyr	4755	29	.	.	.
cord-006860-a3b8hyyr	4756	1	Since	since	IN
cord-006860-a3b8hyyr	4756	2	the	the	DT
cord-006860-a3b8hyyr	4756	3	receptor	receptor	NN
cord-006860-a3b8hyyr	4756	4	dysfunction	dysfunction	NN
cord-006860-a3b8hyyr	4756	5	goes	go	VBZ
cord-006860-a3b8hyyr	4756	6	along	along	RB
cord-006860-a3b8hyyr	4756	7	with	with	IN
cord-006860-a3b8hyyr	4756	8	reduced	reduced	JJ
cord-006860-a3b8hyyr	4756	9	or	or	CC
cord-006860-a3b8hyyr	4756	10	absent	absent	JJ
cord-006860-a3b8hyyr	4756	11	platelet	platelet	NN
cord-006860-a3b8hyyr	4756	12	aggregation	aggregation	NN
cord-006860-a3b8hyyr	4756	13	and	and	CC
cord-006860-a3b8hyyr	4756	14	adhesion	adhesion	NN
cord-006860-a3b8hyyr	4756	15	,	,	,
cord-006860-a3b8hyyr	4756	16	it	-PRON-	PRP
cord-006860-a3b8hyyr	4756	17	causes	cause	VBZ
cord-006860-a3b8hyyr	4756	18	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4756	19	complications	complication	NNS
cord-006860-a3b8hyyr	4756	20	in	in	IN
cord-006860-a3b8hyyr	4756	21	case	case	NN
cord-006860-a3b8hyyr	4756	22	of	of	IN
cord-006860-a3b8hyyr	4756	23	injury	injury	NN
cord-006860-a3b8hyyr	4756	24	.	.	.
cord-006860-a3b8hyyr	4757	1	Here	here	RB
cord-006860-a3b8hyyr	4757	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	4757	3	report	report	VBP
cord-006860-a3b8hyyr	4757	4	about	about	IN
cord-006860-a3b8hyyr	4757	5	a	a	DT
cord-006860-a3b8hyyr	4757	6	60	60	CD
cord-006860-a3b8hyyr	4757	7	years	year	NNS
cord-006860-a3b8hyyr	4757	8	old	old	JJ
cord-006860-a3b8hyyr	4757	9	women	woman	NNS
cord-006860-a3b8hyyr	4757	10	,	,	,
cord-006860-a3b8hyyr	4757	11	who	who	WP
cord-006860-a3b8hyyr	4757	12	suffered	suffer	VBD
cord-006860-a3b8hyyr	4757	13	since	since	IN
cord-006860-a3b8hyyr	4757	14	early	early	JJ
cord-006860-a3b8hyyr	4757	15	childhood	childhood	NN
cord-006860-a3b8hyyr	4757	16	from	from	IN
cord-006860-a3b8hyyr	4757	17	a	a	DT
cord-006860-a3b8hyyr	4757	18	severe	severe	JJ
cord-006860-a3b8hyyr	4757	19	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4757	20	disorder	disorder	NN
cord-006860-a3b8hyyr	4757	21	.	.	.
cord-006860-a3b8hyyr	4758	1	Life	life	NN
cord-006860-a3b8hyyr	4758	2	threating	threating	JJ
cord-006860-a3b8hyyr	4758	3	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4758	4	complications	complication	NNS
cord-006860-a3b8hyyr	4758	5	occured	occur	VBD
cord-006860-a3b8hyyr	4758	6	after	after	IN
cord-006860-a3b8hyyr	4758	7	tooth	tooth	NN
cord-006860-a3b8hyyr	4758	8	extraction	extraction	NN
cord-006860-a3b8hyyr	4758	9	and	and	CC
cord-006860-a3b8hyyr	4758	10	after	after	IN
cord-006860-a3b8hyyr	4758	11	abdominal	abdominal	JJ
cord-006860-a3b8hyyr	4758	12	surgery	surgery	NN
cord-006860-a3b8hyyr	4758	13	.	.	.
cord-006860-a3b8hyyr	4759	1	Analysis	analysis	NN
cord-006860-a3b8hyyr	4759	2	of	of	IN
cord-006860-a3b8hyyr	4759	3	the	the	DT
cord-006860-a3b8hyyr	4759	4	patients	patient	NNS
cord-006860-a3b8hyyr	4759	5	platelets	platelet	NNS
cord-006860-a3b8hyyr	4759	6	revealed	reveal	VBD
cord-006860-a3b8hyyr	4759	7	normal	normal	JJ
cord-006860-a3b8hyyr	4759	8	values	value	NNS
cord-006860-a3b8hyyr	4759	9	for	for	IN
cord-006860-a3b8hyyr	4759	10	the	the	DT
cord-006860-a3b8hyyr	4759	11	platelet	platelet	NN
cord-006860-a3b8hyyr	4759	12	count	count	NN
cord-006860-a3b8hyyr	4759	13	,	,	,
cord-006860-a3b8hyyr	4759	14	whereas	whereas	IN
cord-006860-a3b8hyyr	4759	15	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4759	16	volume	volume	NN
cord-006860-a3b8hyyr	4759	17	showed	show	VBD
cord-006860-a3b8hyyr	4759	18	to	to	TO
cord-006860-a3b8hyyr	4759	19	be	be	VB
cord-006860-a3b8hyyr	4759	20	increased	increase	VBN
cord-006860-a3b8hyyr	4759	21	(	(	-LRB-
cord-006860-a3b8hyyr	4759	22	11	11	CD
cord-006860-a3b8hyyr	4759	23	fl	fl	NNP
cord-006860-a3b8hyyr	4759	24	)	)	-RRB-
cord-006860-a3b8hyyr	4759	25	.	.	.
cord-006860-a3b8hyyr	4760	1	Clot	clot	NN
cord-006860-a3b8hyyr	4760	2	retraction	retraction	NN
cord-006860-a3b8hyyr	4760	3	was	be	VBD
cord-006860-a3b8hyyr	4760	4	diminished	diminish	VBN
cord-006860-a3b8hyyr	4760	5	to	to	IN
cord-006860-a3b8hyyr	4760	6	17	17	CD
cord-006860-a3b8hyyr	4760	7	%	%	NN
cord-006860-a3b8hyyr	4760	8	.	.	.
cord-006860-a3b8hyyr	4761	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	4761	2	adhesion	adhesion	NN
cord-006860-a3b8hyyr	4761	3	to	to	IN
cord-006860-a3b8hyyr	4761	4	siliconised	siliconised	JJ
cord-006860-a3b8hyyr	4761	5	glass	glass	NN
cord-006860-a3b8hyyr	4761	6	and	and	CC
cord-006860-a3b8hyyr	4761	7	human	human	JJ
cord-006860-a3b8hyyr	4761	8	subendothelial	subendothelial	NNP
cord-006860-a3b8hyyr	4761	9	matrix	matrix	NN
cord-006860-a3b8hyyr	4761	10	was	be	VBD
cord-006860-a3b8hyyr	4761	11	reduced	reduce	VBN
cord-006860-a3b8hyyr	4761	12	,	,	,
cord-006860-a3b8hyyr	4761	13	as	as	IN
cord-006860-a3b8hyyr	4761	14	was	be	VBD
cord-006860-a3b8hyyr	4761	15	the	the	DT
cord-006860-a3b8hyyr	4761	16	spreading	spreading	NN
cord-006860-a3b8hyyr	4761	17	of	of	IN
cord-006860-a3b8hyyr	4761	18	the	the	DT
cord-006860-a3b8hyyr	4761	19	platelets	platelet	NNS
cord-006860-a3b8hyyr	4761	20	.	.	.
cord-006860-a3b8hyyr	4762	1	ADP	ADP	NNP
cord-006860-a3b8hyyr	4762	2	(	(	-LRB-
cord-006860-a3b8hyyr	4762	3	I#M	i#m	NN
cord-006860-a3b8hyyr	4762	4	)	)	-RRB-
cord-006860-a3b8hyyr	4762	5	induced	induce	VBN
cord-006860-a3b8hyyr	4762	6	platelet	platelet	NN
cord-006860-a3b8hyyr	4762	7	aggregation	aggregation	NN
cord-006860-a3b8hyyr	4762	8	was	be	VBD
cord-006860-a3b8hyyr	4762	9	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	4762	10	,	,	,
cord-006860-a3b8hyyr	4762	11	while	while	IN
cord-006860-a3b8hyyr	4762	12	collagen-	collagen-	NN
cord-006860-a3b8hyyr	4762	13	,	,	,
cord-006860-a3b8hyyr	4762	14	ristocetin	ristocetin	JJ
cord-006860-a3b8hyyr	4762	15	-	-	:
cord-006860-a3b8hyyr	4762	16	and	and	CC
cord-006860-a3b8hyyr	4762	17	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4762	18	-	-	HYPH
cord-006860-a3b8hyyr	4762	19	induced	induce	VBN
cord-006860-a3b8hyyr	4762	20	aggregation	aggregation	NN
cord-006860-a3b8hyyr	4762	21	showed	show	VBD
cord-006860-a3b8hyyr	4762	22	to	to	TO
cord-006860-a3b8hyyr	4762	23	be	be	VB
cord-006860-a3b8hyyr	4762	24	normal	normal	JJ
cord-006860-a3b8hyyr	4762	25	.	.	.
cord-006860-a3b8hyyr	4763	1	Cross	cross	NN
cord-006860-a3b8hyyr	4763	2	immunelectrophoresis	immunelectrophoresis	NN
cord-006860-a3b8hyyr	4763	3	resulted	result	VBD
cord-006860-a3b8hyyr	4763	4	in	in	IN
cord-006860-a3b8hyyr	4763	5	an	an	DT
cord-006860-a3b8hyyr	4763	6	atypical	atypical	JJ
cord-006860-a3b8hyyr	4763	7	peak	peak	NN
cord-006860-a3b8hyyr	4763	8	of	of	IN
cord-006860-a3b8hyyr	4763	9	GPIIbllla	GPIIbllla	NNS
cord-006860-a3b8hyyr	4763	10	with	with	IN
cord-006860-a3b8hyyr	4763	11	reduced	reduce	VBN
cord-006860-a3b8hyyr	4763	12	electrophoretic	electrophoretic	JJ
cord-006860-a3b8hyyr	4763	13	mobility	mobility	NN
cord-006860-a3b8hyyr	4763	14	.	.	.
cord-006860-a3b8hyyr	4764	1	In	in	IN
cord-006860-a3b8hyyr	4764	2	the	the	DT
cord-006860-a3b8hyyr	4764	3	electroimmunoassay	electroimmunoassay	NN
cord-006860-a3b8hyyr	4764	4	according	accord	VBG
cord-006860-a3b8hyyr	4764	5	to	to	IN
cord-006860-a3b8hyyr	4764	6	Laurell	Laurell	NNP
cord-006860-a3b8hyyr	4764	7	14	14	CD
cord-006860-a3b8hyyr	4764	8	%	%	NN
cord-006860-a3b8hyyr	4764	9	of	of	IN
cord-006860-a3b8hyyr	4764	10	GPIIbllla	GPIIbllla	NNS
cord-006860-a3b8hyyr	4764	11	was	be	VBD
cord-006860-a3b8hyyr	4764	12	detected	detect	VBN
cord-006860-a3b8hyyr	4764	13	.	.	.
cord-006860-a3b8hyyr	4765	1	Moreover	moreover	RB
cord-006860-a3b8hyyr	4765	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	4765	3	observed	observe	VBD
cord-006860-a3b8hyyr	4765	4	a	a	DT
cord-006860-a3b8hyyr	4765	5	markedly	markedly	RB
cord-006860-a3b8hyyr	4765	6	diminished	diminished	JJ
cord-006860-a3b8hyyr	4765	7	125j	125j	NNS
cord-006860-a3b8hyyr	4765	8	-	-	HYPH
cord-006860-a3b8hyyr	4765	9	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4765	10	binding	binding	NN
cord-006860-a3b8hyyr	4765	11	.	.	.
cord-006860-a3b8hyyr	4766	1	Sequence	sequence	NN
cord-006860-a3b8hyyr	4766	2	analysis	analysis	NN
cord-006860-a3b8hyyr	4766	3	of	of	IN
cord-006860-a3b8hyyr	4766	4	the	the	DT
cord-006860-a3b8hyyr	4766	5	GPIIb	GPIIb	NNS
cord-006860-a3b8hyyr	4766	6	and	and	CC
cord-006860-a3b8hyyr	4766	7	GPIIla	GPIIla	NNP
cord-006860-a3b8hyyr	4766	8	cDNA	cdna	NN
cord-006860-a3b8hyyr	4766	9	after	after	IN
cord-006860-a3b8hyyr	4766	10	PCR	PCR	NNP
cord-006860-a3b8hyyr	4766	11	amplification	amplification	NN
cord-006860-a3b8hyyr	4766	12	unraveled	unravel	VBD
cord-006860-a3b8hyyr	4766	13	a	a	DT
cord-006860-a3b8hyyr	4766	14	G2508	G2508	NNP
cord-006860-a3b8hyyr	4766	15	--	--	:
cord-006860-a3b8hyyr	4766	16	,	,	,
cord-006860-a3b8hyyr	4766	17	A	a	DT
cord-006860-a3b8hyyr	4766	18	transition	transition	NN
cord-006860-a3b8hyyr	4766	19	in	in	IN
cord-006860-a3b8hyyr	4766	20	GPIIb	GPIIb	NNS
cord-006860-a3b8hyyr	4766	21	,	,	,
cord-006860-a3b8hyyr	4766	22	substituting	substitute	VBG
cord-006860-a3b8hyyr	4766	23	Gly805	gly805	ADD
cord-006860-a3b8hyyr	4766	24	--	--	:
cord-006860-a3b8hyyr	4766	25	*	*	NFP
cord-006860-a3b8hyyr	4766	26	Glu	Glu	NNP
cord-006860-a3b8hyyr	4766	27	.	.	.
cord-006860-a3b8hyyr	4767	1	The	the	DT
cord-006860-a3b8hyyr	4767	2	structure	structure	NN
cord-006860-a3b8hyyr	4767	3	/	/	SYM
cord-006860-a3b8hyyr	4767	4	function	function	NN
cord-006860-a3b8hyyr	4767	5	relationship	relationship	NN
cord-006860-a3b8hyyr	4767	6	of	of	IN
cord-006860-a3b8hyyr	4767	7	this	this	DT
cord-006860-a3b8hyyr	4767	8	mutation	mutation	NN
cord-006860-a3b8hyyr	4767	9	has	have	VBZ
cord-006860-a3b8hyyr	4767	10	still	still	RB
cord-006860-a3b8hyyr	4767	11	to	to	TO
cord-006860-a3b8hyyr	4767	12	be	be	VB
cord-006860-a3b8hyyr	4767	13	investigated	investigate	VBN
cord-006860-a3b8hyyr	4767	14	.	.	.
cord-006860-a3b8hyyr	4768	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4768	2	report	report	VBP
cord-006860-a3b8hyyr	4768	3	two	two	CD
cord-006860-a3b8hyyr	4768	4	new	new	JJ
cord-006860-a3b8hyyr	4768	5	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	4768	6	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4768	7	variants	variant	NNS
cord-006860-a3b8hyyr	4768	8	,	,	,
cord-006860-a3b8hyyr	4768	9	denoted	denote	VBN
cord-006860-a3b8hyyr	4768	10	as	as	IN
cord-006860-a3b8hyyr	4768	11	Bem	Bem	NNP
cord-006860-a3b8hyyr	4768	12	IV	IV	NNP
cord-006860-a3b8hyyr	4768	13	and	and	CC
cord-006860-a3b8hyyr	4768	14	Milano	Milano	NNP
cord-006860-a3b8hyyr	4768	15	XI	XI	NNP
cord-006860-a3b8hyyr	4768	16	,	,	,
cord-006860-a3b8hyyr	4768	17	both	both	DT
cord-006860-a3b8hyyr	4768	18	having	have	VBG
cord-006860-a3b8hyyr	4768	19	an	an	DT
cord-006860-a3b8hyyr	4768	20	exchange	exchange	NN
cord-006860-a3b8hyyr	4768	21	of	of	IN
cord-006860-a3b8hyyr	4768	22	arginine	arginine	NN
cord-006860-a3b8hyyr	4768	23	to	to	IN
cord-006860-a3b8hyyr	4768	24	histidine	histidine	NN
cord-006860-a3b8hyyr	4768	25	in	in	IN
cord-006860-a3b8hyyr	4768	26	position	position	NN
cord-006860-a3b8hyyr	4768	27	16	16	CD
cord-006860-a3b8hyyr	4768	28	of	of	IN
cord-006860-a3b8hyyr	4768	29	the	the	DT
cord-006860-a3b8hyyr	4768	30	Ac~-chain	ac~-chain	NN
cord-006860-a3b8hyyr	4768	31	.	.	.
cord-006860-a3b8hyyr	4769	1	Routine	routine	JJ
cord-006860-a3b8hyyr	4769	2	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4769	3	studies	study	NNS
cord-006860-a3b8hyyr	4769	4	revealed	reveal	VBD
cord-006860-a3b8hyyr	4769	5	prolonged	prolonged	JJ
cord-006860-a3b8hyyr	4769	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4769	7	and	and	CC
cord-006860-a3b8hyyr	4769	8	reptilase	reptilase	NN
cord-006860-a3b8hyyr	4769	9	clotting	clotting	NN
cord-006860-a3b8hyyr	4769	10	times	time	NNS
cord-006860-a3b8hyyr	4769	11	,	,	,
cord-006860-a3b8hyyr	4769	12	low	low	JJ
cord-006860-a3b8hyyr	4769	13	plasma	plasma	NN
cord-006860-a3b8hyyr	4769	14	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4769	15	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4769	16	determined	determine	VBN
cord-006860-a3b8hyyr	4769	17	by	by	IN
cord-006860-a3b8hyyr	4769	18	a	a	DT
cord-006860-a3b8hyyr	4769	19	functional	functional	JJ
cord-006860-a3b8hyyr	4769	20	assay	assay	NN
cord-006860-a3b8hyyr	4769	21	but	but	CC
cord-006860-a3b8hyyr	4769	22	normal	normal	JJ
cord-006860-a3b8hyyr	4769	23	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4769	24	levels	level	NNS
cord-006860-a3b8hyyr	4769	25	measured	measure	VBN
cord-006860-a3b8hyyr	4769	26	by	by	IN
cord-006860-a3b8hyyr	4769	27	the	the	DT
cord-006860-a3b8hyyr	4769	28	immunological	immunological	JJ
cord-006860-a3b8hyyr	4769	29	assay	assay	NN
cord-006860-a3b8hyyr	4769	30	.	.	.
cord-006860-a3b8hyyr	4770	1	The	the	DT
cord-006860-a3b8hyyr	4770	2	onset	onset	NN
cord-006860-a3b8hyyr	4770	3	of	of	IN
cord-006860-a3b8hyyr	4770	4	turbidity	turbidity	NN
cord-006860-a3b8hyyr	4770	5	increase	increase	NN
cord-006860-a3b8hyyr	4770	6	following	follow	VBG
cord-006860-a3b8hyyr	4770	7	addition	addition	NN
cord-006860-a3b8hyyr	4770	8	ofthrombin	ofthrombin	NNP
cord-006860-a3b8hyyr	4770	9	to	to	IN
cord-006860-a3b8hyyr	4770	10	purified	purify	VBN
cord-006860-a3b8hyyr	4770	11	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4770	12	was	be	VBD
cord-006860-a3b8hyyr	4770	13	markedly	markedly	RB
cord-006860-a3b8hyyr	4770	14	delayed	delay	VBN
cord-006860-a3b8hyyr	4770	15	in	in	IN
cord-006860-a3b8hyyr	4770	16	both	both	DT
cord-006860-a3b8hyyr	4770	17	variants	variant	NNS
cord-006860-a3b8hyyr	4770	18	.	.	.
cord-006860-a3b8hyyr	4771	1	Release	release	NN
cord-006860-a3b8hyyr	4771	2	of	of	IN
cord-006860-a3b8hyyr	4771	3	fibrinopeptide	fibrinopeptide	NN
cord-006860-a3b8hyyr	4771	4	B	b	NN
cord-006860-a3b8hyyr	4771	5	by	by	IN
cord-006860-a3b8hyyr	4771	6	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4771	7	,	,	,
cord-006860-a3b8hyyr	4771	8	measured	measure	VBN
cord-006860-a3b8hyyr	4771	9	by	by	IN
cord-006860-a3b8hyyr	4771	10	reversed	reversed	JJ
cord-006860-a3b8hyyr	4771	11	phase	phase	NN
cord-006860-a3b8hyyr	4771	12	HPLC	HPLC	NNP
cord-006860-a3b8hyyr	4771	13	,	,	,
cord-006860-a3b8hyyr	4771	14	was	be	VBD
cord-006860-a3b8hyyr	4771	15	normal	normal	JJ
cord-006860-a3b8hyyr	4771	16	whereas	whereas	IN
cord-006860-a3b8hyyr	4771	17	only	only	RB
cord-006860-a3b8hyyr	4771	18	one	one	CD
cord-006860-a3b8hyyr	4771	19	half	half	NN
cord-006860-a3b8hyyr	4771	20	amount	amount	NN
cord-006860-a3b8hyyr	4771	21	of	of	IN
cord-006860-a3b8hyyr	4771	22	normal	normal	JJ
cord-006860-a3b8hyyr	4771	23	fibrinopeptide	fibrinopeptide	NN
cord-006860-a3b8hyyr	4771	24	A	a	NN
cord-006860-a3b8hyyr	4771	25	was	be	VBD
cord-006860-a3b8hyyr	4771	26	released	release	VBN
cord-006860-a3b8hyyr	4771	27	.	.	.
cord-006860-a3b8hyyr	4772	1	In	in	IN
cord-006860-a3b8hyyr	4772	2	addition	addition	NN
cord-006860-a3b8hyyr	4772	3	to	to	IN
cord-006860-a3b8hyyr	4772	4	normal	normal	JJ
cord-006860-a3b8hyyr	4772	5	fibrinopeptide	fibrinopeptide	RB
cord-006860-a3b8hyyr	4772	6	A	a	NN
cord-006860-a3b8hyyr	4772	7	,	,	,
cord-006860-a3b8hyyr	4772	8	an	an	DT
cord-006860-a3b8hyyr	4772	9	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	4772	10	fibrinopeptide	fibrinopeptide	NN
cord-006860-a3b8hyyr	4773	1	A	a	DT
cord-006860-a3b8hyyr	4773	2	*	*	NFP
cord-006860-a3b8hyyr	4773	3	was	be	VBD
cord-006860-a3b8hyyr	4773	4	cleaved	cleave	VBN
cord-006860-a3b8hyyr	4773	5	from	from	IN
cord-006860-a3b8hyyr	4773	6	both	both	DT
cord-006860-a3b8hyyr	4773	7	dysfunctional	dysfunctional	JJ
cord-006860-a3b8hyyr	4773	8	fibrinogens	fibrinogen	NNS
cord-006860-a3b8hyyr	4773	9	.	.	.
cord-006860-a3b8hyyr	4774	1	The	the	DT
cord-006860-a3b8hyyr	4774	2	structural	structural	JJ
cord-006860-a3b8hyyr	4774	3	defect	defect	NN
cord-006860-a3b8hyyr	4774	4	was	be	VBD
cord-006860-a3b8hyyr	4774	5	determined	determine	VBN
cord-006860-a3b8hyyr	4774	6	by	by	IN
cord-006860-a3b8hyyr	4774	7	asymmetric	asymmetric	JJ
cord-006860-a3b8hyyr	4774	8	PCR	PCR	NNP
cord-006860-a3b8hyyr	4774	9	and	and	CC
cord-006860-a3b8hyyr	4774	10	direct	direct	JJ
cord-006860-a3b8hyyr	4774	11	sequencing	sequencing	NN
cord-006860-a3b8hyyr	4774	12	of	of	IN
cord-006860-a3b8hyyr	4774	13	a	a	DT
cord-006860-a3b8hyyr	4774	14	gene	gene	NN
cord-006860-a3b8hyyr	4774	15	fragment	fragment	NN
cord-006860-a3b8hyyr	4774	16	coding	code	VBG
cord-006860-a3b8hyyr	4774	17	for	for	IN
cord-006860-a3b8hyyr	4774	18	the	the	DT
cord-006860-a3b8hyyr	4774	19	NH2-terminus	nh2-terminus	NN
cord-006860-a3b8hyyr	4774	20	of	of	IN
cord-006860-a3b8hyyr	4774	21	the	the	DT
cord-006860-a3b8hyyr	4774	22	Aachain	Aachain	NNP
cord-006860-a3b8hyyr	4774	23	.	.	.
cord-006860-a3b8hyyr	4775	1	Both	both	DT
cord-006860-a3b8hyyr	4775	2	variants	variant	NNS
cord-006860-a3b8hyyr	4775	3	were	be	VBD
cord-006860-a3b8hyyr	4775	4	found	find	VBN
cord-006860-a3b8hyyr	4775	5	to	to	TO
cord-006860-a3b8hyyr	4775	6	be	be	VB
cord-006860-a3b8hyyr	4775	7	heterozygous	heterozygous	JJ
cord-006860-a3b8hyyr	4775	8	for	for	IN
cord-006860-a3b8hyyr	4775	9	the	the	DT
cord-006860-a3b8hyyr	4775	10	transition	transition	NN
cord-006860-a3b8hyyr	4775	11	G	g	NN
cord-006860-a3b8hyyr	4775	12	to	to	IN
cord-006860-a3b8hyyr	4775	13	A	a	NN
cord-006860-a3b8hyyr	4775	14	at	at	IN
cord-006860-a3b8hyyr	4775	15	nucleotide	nucleotide	JJ
cord-006860-a3b8hyyr	4775	16	position	position	NN
cord-006860-a3b8hyyr	4775	17	1203	1203	CD
cord-006860-a3b8hyyr	4775	18	,	,	,
cord-006860-a3b8hyyr	4775	19	leading	lead	VBG
cord-006860-a3b8hyyr	4775	20	to	to	IN
cord-006860-a3b8hyyr	4775	21	the	the	DT
cord-006860-a3b8hyyr	4775	22	substitution	substitution	NN
cord-006860-a3b8hyyr	4775	23	Actl6	Actl6	NNP
cord-006860-a3b8hyyr	4776	1	Arg-->His	arg-->his	UH
cord-006860-a3b8hyyr	4776	2	,	,	,
cord-006860-a3b8hyyr	4776	3	resulting	result	VBG
cord-006860-a3b8hyyr	4776	4	in	in	IN
cord-006860-a3b8hyyr	4776	5	a	a	DT
cord-006860-a3b8hyyr	4776	6	delayed	delay	VBN
cord-006860-a3b8hyyr	4776	7	fibrin	fibrin	NN
cord-006860-a3b8hyyr	4776	8	polymerization	polymerization	NN
cord-006860-a3b8hyyr	4776	9	.	.	.
cord-006860-a3b8hyyr	4777	1	The	the	DT
cord-006860-a3b8hyyr	4777	2	simple	simple	JJ
cord-006860-a3b8hyyr	4777	3	assay	assay	NN
cord-006860-a3b8hyyr	4777	4	permits	permit	VBZ
cord-006860-a3b8hyyr	4777	5	detection	detection	NN
cord-006860-a3b8hyyr	4777	6	of	of	IN
cord-006860-a3b8hyyr	4777	7	the	the	DT
cord-006860-a3b8hyyr	4777	8	most	most	RBS
cord-006860-a3b8hyyr	4777	9	common	common	JJ
cord-006860-a3b8hyyr	4777	10	amino	amino	NN
cord-006860-a3b8hyyr	4777	11	acid	acid	NN
cord-006860-a3b8hyyr	4777	12	substitutions	substitution	NNS
cord-006860-a3b8hyyr	4777	13	occuring	occur	VBG
cord-006860-a3b8hyyr	4777	14	in	in	IN
cord-006860-a3b8hyyr	4777	15	the	the	DT
cord-006860-a3b8hyyr	4777	16	NH2-terminus	nh2-terminus	NN
cord-006860-a3b8hyyr	4777	17	of	of	IN
cord-006860-a3b8hyyr	4777	18	the	the	DT
cord-006860-a3b8hyyr	4777	19	Ac~-chain	ac~-chain	CD
cord-006860-a3b8hyyr	4777	20	of	of	IN
cord-006860-a3b8hyyr	4777	21	the	the	DT
cord-006860-a3b8hyyr	4777	22	functionally	functionally	RB
cord-006860-a3b8hyyr	4777	23	abnormal	abnormal	JJ
cord-006860-a3b8hyyr	4777	24	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4777	25	variants	variant	NNS
cord-006860-a3b8hyyr	4777	26	.	.	.
cord-006860-a3b8hyyr	4778	1	Protein	protein	NN
cord-006860-a3b8hyyr	4778	2	C	C	NNP
cord-006860-a3b8hyyr	4778	3	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4778	4	(	(	-LRB-
cord-006860-a3b8hyyr	4778	5	PCI	PCI	NNP
cord-006860-a3b8hyyr	4778	6	)	)	-RRB-
cord-006860-a3b8hyyr	4778	7	a	a	DT
cord-006860-a3b8hyyr	4778	8	member	member	NN
cord-006860-a3b8hyyr	4778	9	of	of	IN
cord-006860-a3b8hyyr	4778	10	the	the	DT
cord-006860-a3b8hyyr	4778	11	serpin	serpin	NNP
cord-006860-a3b8hyyr	4778	12	family	family	NN
cord-006860-a3b8hyyr	4778	13	is	be	VBZ
cord-006860-a3b8hyyr	4778	14	also	also	RB
cord-006860-a3b8hyyr	4778	15	known	know	VBN
cord-006860-a3b8hyyr	4778	16	as	as	IN
cord-006860-a3b8hyyr	4778	17	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4778	18	activator-3	activator-3	NNP
cord-006860-a3b8hyyr	4778	19	(	(	-LRB-
cord-006860-a3b8hyyr	4778	20	PAl-3	PAl-3	NNP
cord-006860-a3b8hyyr	4778	21	)	)	-RRB-
cord-006860-a3b8hyyr	4778	22	.	.	.
cord-006860-a3b8hyyr	4779	1	PCI	PCI	NNP
cord-006860-a3b8hyyr	4779	2	was	be	VBD
cord-006860-a3b8hyyr	4779	3	first	first	RB
cord-006860-a3b8hyyr	4779	4	described	describe	VBN
cord-006860-a3b8hyyr	4779	5	as	as	IN
cord-006860-a3b8hyyr	4779	6	a	a	DT
cord-006860-a3b8hyyr	4779	7	component	component	NN
cord-006860-a3b8hyyr	4779	8	of	of	IN
cord-006860-a3b8hyyr	4779	9	human	human	JJ
cord-006860-a3b8hyyr	4779	10	plasma	plasma	NN
cord-006860-a3b8hyyr	4779	11	,	,	,
cord-006860-a3b8hyyr	4779	12	regulating	regulate	VBG
cord-006860-a3b8hyyr	4779	13	the	the	DT
cord-006860-a3b8hyyr	4779	14	activity	activity	NN
cord-006860-a3b8hyyr	4779	15	of	of	IN
cord-006860-a3b8hyyr	4779	16	activated	activate	VBN
cord-006860-a3b8hyyr	4779	17	protein	protein	NN
cord-006860-a3b8hyyr	4779	18	C	C	NNP
cord-006860-a3b8hyyr	4779	19	and	and	CC
cord-006860-a3b8hyyr	4779	20	other	other	JJ
cord-006860-a3b8hyyr	4779	21	sedne	sedne	NN
cord-006860-a3b8hyyr	4779	22	proteases	protease	NNS
cord-006860-a3b8hyyr	4779	23	of	of	IN
cord-006860-a3b8hyyr	4779	24	the	the	DT
cord-006860-a3b8hyyr	4779	25	human	human	JJ
cord-006860-a3b8hyyr	4779	26	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4779	27	and	and	CC
cord-006860-a3b8hyyr	4779	28	fibdnolysis	fibdnolysis	NN
cord-006860-a3b8hyyr	4779	29	system	system	NN
cord-006860-a3b8hyyr	4779	30	.	.	.
cord-006860-a3b8hyyr	4780	1	Since	since	IN
cord-006860-a3b8hyyr	4780	2	then	then	RB
cord-006860-a3b8hyyr	4780	3	PCI	PCI	NNP
cord-006860-a3b8hyyr	4780	4	was	be	VBD
cord-006860-a3b8hyyr	4780	5	found	find	VBN
cord-006860-a3b8hyyr	4780	6	to	to	TO
cord-006860-a3b8hyyr	4780	7	be	be	VB
cord-006860-a3b8hyyr	4780	8	present	present	JJ
cord-006860-a3b8hyyr	4780	9	in	in	IN
cord-006860-a3b8hyyr	4780	10	extra	extra	JJ
cord-006860-a3b8hyyr	4780	11	-	-	JJ
cord-006860-a3b8hyyr	4780	12	plasmatic	plasmatic	JJ
cord-006860-a3b8hyyr	4780	13	systems	system	NNS
cord-006860-a3b8hyyr	4780	14	also	also	RB
cord-006860-a3b8hyyr	4780	15	.	.	.
cord-006860-a3b8hyyr	4781	1	High	high	JJ
cord-006860-a3b8hyyr	4781	2	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4781	3	of	of	IN
cord-006860-a3b8hyyr	4781	4	PCI	PCI	NNP
cord-006860-a3b8hyyr	4781	5	were	be	VBD
cord-006860-a3b8hyyr	4781	6	detected	detect	VBN
cord-006860-a3b8hyyr	4781	7	in	in	IN
cord-006860-a3b8hyyr	4781	8	human	human	JJ
cord-006860-a3b8hyyr	4781	9	seminal	seminal	JJ
cord-006860-a3b8hyyr	4781	10	plasma	plasma	NN
cord-006860-a3b8hyyr	4781	11	suggesting	suggest	VBG
cord-006860-a3b8hyyr	4781	12	a	a	DT
cord-006860-a3b8hyyr	4781	13	role	role	NN
cord-006860-a3b8hyyr	4781	14	for	for	IN
cord-006860-a3b8hyyr	4781	15	PCI	PCI	NNP
cord-006860-a3b8hyyr	4781	16	in	in	IN
cord-006860-a3b8hyyr	4781	17	human	human	JJ
cord-006860-a3b8hyyr	4781	18	fertility	fertility	NN
cord-006860-a3b8hyyr	4781	19	.	.	.
cord-006860-a3b8hyyr	4782	1	Significant	significant	JJ
cord-006860-a3b8hyyr	4782	2	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4782	3	of	of	IN
cord-006860-a3b8hyyr	4782	4	PCI	pci	NN
cord-006860-a3b8hyyr	4782	5	mRNA	mrna	NN
cord-006860-a3b8hyyr	4782	6	and	and	CC
cord-006860-a3b8hyyr	4782	7	antigen	antigen	NN
cord-006860-a3b8hyyr	4782	8	were	be	VBD
cord-006860-a3b8hyyr	4782	9	located	locate	VBN
cord-006860-a3b8hyyr	4782	10	in	in	IN
cord-006860-a3b8hyyr	4782	11	lysosomes	lysosome	NNS
cord-006860-a3b8hyyr	4782	12	of	of	IN
cord-006860-a3b8hyyr	4782	13	proximal	proximal	JJ
cord-006860-a3b8hyyr	4782	14	tubular	tubular	JJ
cord-006860-a3b8hyyr	4782	15	kidney	kidney	NN
cord-006860-a3b8hyyr	4782	16	cells	cell	NNS
cord-006860-a3b8hyyr	4782	17	suggesting	suggest	VBG
cord-006860-a3b8hyyr	4782	18	an	an	DT
cord-006860-a3b8hyyr	4782	19	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	4782	20	function	function	NN
cord-006860-a3b8hyyr	4782	21	for	for	IN
cord-006860-a3b8hyyr	4782	22	PCI	pci	NN
cord-006860-a3b8hyyr	4782	23	in	in	IN
cord-006860-a3b8hyyr	4782	24	this	this	DT
cord-006860-a3b8hyyr	4782	25	environment	environment	NN
cord-006860-a3b8hyyr	4782	26	.	.	.
cord-006860-a3b8hyyr	4783	1	In	in	IN
cord-006860-a3b8hyyr	4783	2	this	this	DT
cord-006860-a3b8hyyr	4783	3	study	study	NN
cord-006860-a3b8hyyr	4783	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	4783	5	present	present	VBP
cord-006860-a3b8hyyr	4783	6	evidence	evidence	NN
cord-006860-a3b8hyyr	4783	7	that	that	IN
cord-006860-a3b8hyyr	4783	8	PCI	PCI	NNP
cord-006860-a3b8hyyr	4783	9	is	be	VBZ
cord-006860-a3b8hyyr	4783	10	also	also	RB
cord-006860-a3b8hyyr	4783	11	present	present	JJ
cord-006860-a3b8hyyr	4783	12	in	in	IN
cord-006860-a3b8hyyr	4783	13	human	human	JJ
cord-006860-a3b8hyyr	4783	14	pancreas	pancrea	NNS
cord-006860-a3b8hyyr	4783	15	.	.	.
cord-006860-a3b8hyyr	4784	1	RNA	RNA	NNP
cord-006860-a3b8hyyr	4784	2	from	from	IN
cord-006860-a3b8hyyr	4784	3	human	human	JJ
cord-006860-a3b8hyyr	4784	4	pancreas	pancreas	NN
cord-006860-a3b8hyyr	4784	5	was	be	VBD
cord-006860-a3b8hyyr	4784	6	reverse	reverse	RB
cord-006860-a3b8hyyr	4784	7	transcribed	transcribe	VBN
cord-006860-a3b8hyyr	4784	8	and	and	CC
cord-006860-a3b8hyyr	4784	9	PCR	PCR	NNP
cord-006860-a3b8hyyr	4784	10	amplified	amplify	VBD
cord-006860-a3b8hyyr	4784	11	.	.	.
cord-006860-a3b8hyyr	4785	1	The	the	DT
cord-006860-a3b8hyyr	4785	2	resulting	result	VBG
cord-006860-a3b8hyyr	4785	3	PCI	pci	NN
cord-006860-a3b8hyyr	4785	4	cDNA	cdna	NN
cord-006860-a3b8hyyr	4785	5	was	be	VBD
cord-006860-a3b8hyyr	4785	6	identical	identical	JJ
cord-006860-a3b8hyyr	4785	7	with	with	IN
cord-006860-a3b8hyyr	4785	8	PCI	pci	NN
cord-006860-a3b8hyyr	4785	9	cDNA	cdna	NN
cord-006860-a3b8hyyr	4785	10	from	from	IN
cord-006860-a3b8hyyr	4785	11	human	human	JJ
cord-006860-a3b8hyyr	4785	12	liver	liver	NN
cord-006860-a3b8hyyr	4785	13	.	.	.
cord-006860-a3b8hyyr	4786	1	~P	~P	NNP
cord-006860-a3b8hyyr	4786	2	labeled	label	VBN
cord-006860-a3b8hyyr	4786	3	antisense	antisense	NN
cord-006860-a3b8hyyr	4786	4	RNA	RNA	NNP
cord-006860-a3b8hyyr	4786	5	probes	probe	NNS
cord-006860-a3b8hyyr	4786	6	used	use	VBN
cord-006860-a3b8hyyr	4786	7	in	in	RP
cord-006860-a3b8hyyr	4786	8	in	in	IN
cord-006860-a3b8hyyr	4786	9	situ	situ	JJ
cord-006860-a3b8hyyr	4786	10	hybridization	hybridization	NN
cord-006860-a3b8hyyr	4786	11	experiments	experiment	NNS
cord-006860-a3b8hyyr	4786	12	with	with	IN
cord-006860-a3b8hyyr	4786	13	human	human	JJ
cord-006860-a3b8hyyr	4786	14	pancreas	pancreas	NN
cord-006860-a3b8hyyr	4786	15	tissue	tissue	NN
cord-006860-a3b8hyyr	4786	16	sections	section	NNS
cord-006860-a3b8hyyr	4786	17	showed	show	VBD
cord-006860-a3b8hyyr	4786	18	that	that	IN
cord-006860-a3b8hyyr	4786	19	PCI	PCI	NNP
cord-006860-a3b8hyyr	4786	20	RNA	RNA	NNP
cord-006860-a3b8hyyr	4786	21	was	be	VBD
cord-006860-a3b8hyyr	4786	22	located	locate	VBN
cord-006860-a3b8hyyr	4786	23	in	in	IN
cord-006860-a3b8hyyr	4786	24	the	the	DT
cord-006860-a3b8hyyr	4786	25	acinar	acinar	NNP
cord-006860-a3b8hyyr	4786	26	ceils	ceils	NNP
cord-006860-a3b8hyyr	4786	27	.	.	.
cord-006860-a3b8hyyr	4787	1	Pancreatic	pancreatic	JJ
cord-006860-a3b8hyyr	4787	2	fluid	fluid	NN
cord-006860-a3b8hyyr	4787	3	was	be	VBD
cord-006860-a3b8hyyr	4787	4	analyzed	analyze	VBN
cord-006860-a3b8hyyr	4787	5	by	by	IN
cord-006860-a3b8hyyr	4787	6	SDS	SDS	NNP
cord-006860-a3b8hyyr	4787	7	-	-	HYPH
cord-006860-a3b8hyyr	4787	8	PAGE	PAGE	NNP
cord-006860-a3b8hyyr	4787	9	and	and	CC
cord-006860-a3b8hyyr	4787	10	immunoblotting	immunoblotting	NN
cord-006860-a3b8hyyr	4787	11	.	.	.
cord-006860-a3b8hyyr	4788	1	Using	use	VBG
cord-006860-a3b8hyyr	4788	2	monospecific	monospecific	JJ
cord-006860-a3b8hyyr	4788	3	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4788	4	directed	direct	VBN
cord-006860-a3b8hyyr	4788	5	against	against	IN
cord-006860-a3b8hyyr	4788	6	human	human	JJ
cord-006860-a3b8hyyr	4788	7	plasma	plasma	NN
cord-006860-a3b8hyyr	4788	8	PCI	PCI	NNP
cord-006860-a3b8hyyr	4788	9	,	,	,
cord-006860-a3b8hyyr	4788	10	a	a	DT
cord-006860-a3b8hyyr	4788	11	57	57	CD
cord-006860-a3b8hyyr	4788	12	000	000	CD
cord-006860-a3b8hyyr	4788	13	MW	mw	NN
cord-006860-a3b8hyyr	4788	14	protein	protein	NN
cord-006860-a3b8hyyr	4788	15	band	band	NN
cord-006860-a3b8hyyr	4788	16	was	be	VBD
cord-006860-a3b8hyyr	4788	17	observed	observe	VBN
cord-006860-a3b8hyyr	4788	18	which	which	WDT
cord-006860-a3b8hyyr	4788	19	comigrated	comigrate	VBN
cord-006860-a3b8hyyr	4788	20	with	with	IN
cord-006860-a3b8hyyr	4788	21	purified	purify	VBN
cord-006860-a3b8hyyr	4788	22	human	human	JJ
cord-006860-a3b8hyyr	4788	23	plasma	plasma	NN
cord-006860-a3b8hyyr	4788	24	PCI	pci	NN
cord-006860-a3b8hyyr	4788	25	.	.	.
cord-006860-a3b8hyyr	4789	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	4789	2	results	result	NNS
cord-006860-a3b8hyyr	4789	3	show	show	VBP
cord-006860-a3b8hyyr	4789	4	that	that	IN
cord-006860-a3b8hyyr	4789	5	pancreas	pancreas	NN
cord-006860-a3b8hyyr	4789	6	cells	cell	NNS
cord-006860-a3b8hyyr	4789	7	contain	contain	VBP
cord-006860-a3b8hyyr	4789	8	a	a	DT
cord-006860-a3b8hyyr	4789	9	significant	significant	JJ
cord-006860-a3b8hyyr	4789	10	concentration	concentration	NN
cord-006860-a3b8hyyr	4789	11	of	of	IN
cord-006860-a3b8hyyr	4789	12	PCI	PCI	NNP
cord-006860-a3b8hyyr	4789	13	mRNA	mrna	NN
cord-006860-a3b8hyyr	4789	14	.	.	.
cord-006860-a3b8hyyr	4790	1	This	this	DT
cord-006860-a3b8hyyr	4790	2	message	message	NN
cord-006860-a3b8hyyr	4790	3	is	be	VBZ
cord-006860-a3b8hyyr	4790	4	localized	localize	VBN
cord-006860-a3b8hyyr	4790	5	in	in	IN
cord-006860-a3b8hyyr	4790	6	the	the	DT
cord-006860-a3b8hyyr	4790	7	secretory	secretory	JJ
cord-006860-a3b8hyyr	4790	8	acinar	acinar	NN
cord-006860-a3b8hyyr	4790	9	cells	cell	NNS
cord-006860-a3b8hyyr	4790	10	.	.	.
cord-006860-a3b8hyyr	4791	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	4791	2	we	-PRON-	PRP
cord-006860-a3b8hyyr	4791	3	conclude	conclude	VBP
cord-006860-a3b8hyyr	4791	4	that	that	IN
cord-006860-a3b8hyyr	4791	5	PCI	pci	NN
cord-006860-a3b8hyyr	4791	6	antigen	antigen	NN
cord-006860-a3b8hyyr	4791	7	found	find	VBN
cord-006860-a3b8hyyr	4791	8	in	in	IN
cord-006860-a3b8hyyr	4791	9	pancreatic	pancreatic	JJ
cord-006860-a3b8hyyr	4791	10	fluid	fluid	NN
cord-006860-a3b8hyyr	4791	11	is	be	VBZ
cord-006860-a3b8hyyr	4791	12	likely	likely	JJ
cord-006860-a3b8hyyr	4791	13	to	to	TO
cord-006860-a3b8hyyr	4791	14	originate	originate	VB
cord-006860-a3b8hyyr	4791	15	in	in	IN
cord-006860-a3b8hyyr	4791	16	the	the	DT
cord-006860-a3b8hyyr	4791	17	pancreas	pancreas	NN
cord-006860-a3b8hyyr	4791	18	.	.	.
cord-006860-a3b8hyyr	4792	1	The	the	DT
cord-006860-a3b8hyyr	4792	2	role	role	NN
cord-006860-a3b8hyyr	4792	3	of	of	IN
cord-006860-a3b8hyyr	4792	4	pancreatic	pancreatic	JJ
cord-006860-a3b8hyyr	4792	5	PCI	pci	NN
cord-006860-a3b8hyyr	4792	6	is	be	VBZ
cord-006860-a3b8hyyr	4792	7	unknown	unknown	JJ
cord-006860-a3b8hyyr	4792	8	at	at	IN
cord-006860-a3b8hyyr	4792	9	present	present	NN
cord-006860-a3b8hyyr	4792	10	.	.	.
cord-006860-a3b8hyyr	4793	1	However	however	RB
cord-006860-a3b8hyyr	4793	2	,	,	,
cord-006860-a3b8hyyr	4793	3	since	since	IN
cord-006860-a3b8hyyr	4793	4	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4793	5	and	and	CC
cord-006860-a3b8hyyr	4793	6	systemic	systemic	JJ
cord-006860-a3b8hyyr	4793	7	hypercoagulable	hypercoagulable	JJ
cord-006860-a3b8hyyr	4793	8	states	state	NNS
cord-006860-a3b8hyyr	4793	9	are	be	VBP
cord-006860-a3b8hyyr	4793	10	known	know	VBN
cord-006860-a3b8hyyr	4793	11	complications	complication	NNS
cord-006860-a3b8hyyr	4793	12	of	of	IN
cord-006860-a3b8hyyr	4793	13	pancreatic	pancreatic	JJ
cord-006860-a3b8hyyr	4793	14	diseases	disease	NNS
cord-006860-a3b8hyyr	4793	15	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4793	16	results	result	NNS
cord-006860-a3b8hyyr	4793	17	and	and	CC
cord-006860-a3b8hyyr	4793	18	in	in	IN
cord-006860-a3b8hyyr	4793	19	vitro	vitro	FW
cord-006860-a3b8hyyr	4793	20	experiments	experiment	NNS
cord-006860-a3b8hyyr	4793	21	by	by	IN
cord-006860-a3b8hyyr	4793	22	others	other	NNS
cord-006860-a3b8hyyr	4793	23	showing	show	VBG
cord-006860-a3b8hyyr	4793	24	that	that	IN
cord-006860-a3b8hyyr	4793	25	PCI	PCI	NNP
cord-006860-a3b8hyyr	4793	26	can	can	MD
cord-006860-a3b8hyyr	4793	27	inhibit	inhibit	VB
cord-006860-a3b8hyyr	4793	28	pancreatic	pancreatic	JJ
cord-006860-a3b8hyyr	4793	29	enzymes	enzyme	NNS
cord-006860-a3b8hyyr	4793	30	such	such	JJ
cord-006860-a3b8hyyr	4793	31	as	as	IN
cord-006860-a3b8hyyr	4793	32	chymotrypsin	chymotrypsin	NNP
cord-006860-a3b8hyyr	4793	33	and	and	CC
cord-006860-a3b8hyyr	4793	34	trypsin	trypsin	NN
cord-006860-a3b8hyyr	4793	35	indicate	indicate	VBP
cord-006860-a3b8hyyr	4793	36	that	that	IN
cord-006860-a3b8hyyr	4793	37	PCI	PCI	NNP
cord-006860-a3b8hyyr	4793	38	may	may	MD
cord-006860-a3b8hyyr	4793	39	be	be	VB
cord-006860-a3b8hyyr	4793	40	part	part	NN
cord-006860-a3b8hyyr	4793	41	of	of	IN
cord-006860-a3b8hyyr	4793	42	the	the	DT
cord-006860-a3b8hyyr	4793	43	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4793	44	potential	potential	NN
cord-006860-a3b8hyyr	4793	45	which	which	WDT
cord-006860-a3b8hyyr	4793	46	protects	protect	VBZ
cord-006860-a3b8hyyr	4793	47	pancreatic	pancreatic	JJ
cord-006860-a3b8hyyr	4793	48	tissue	tissue	NN
cord-006860-a3b8hyyr	4793	49	from	from	IN
cord-006860-a3b8hyyr	4793	50	auto	auto	NN
cord-006860-a3b8hyyr	4793	51	degradation	degradation	NN
cord-006860-a3b8hyyr	4793	52	.	.	.
cord-006860-a3b8hyyr	4794	1	These	these	DT
cord-006860-a3b8hyyr	4794	2	inhibitors	inhibitor	NNS
cord-006860-a3b8hyyr	4794	3	normally	normally	RB
cord-006860-a3b8hyyr	4794	4	prevent	prevent	VBP
cord-006860-a3b8hyyr	4794	5	the	the	DT
cord-006860-a3b8hyyr	4794	6	release	release	NN
cord-006860-a3b8hyyr	4794	7	of	of	IN
cord-006860-a3b8hyyr	4794	8	active	active	JJ
cord-006860-a3b8hyyr	4794	9	pancreatic	pancreatic	JJ
cord-006860-a3b8hyyr	4794	10	proteases	protease	NNS
cord-006860-a3b8hyyr	4794	11	into	into	IN
cord-006860-a3b8hyyr	4794	12	the	the	DT
cord-006860-a3b8hyyr	4794	13	vasculature	vasculature	NN
cord-006860-a3b8hyyr	4794	14	or	or	CC
cord-006860-a3b8hyyr	4794	15	microcirculation	microcirculation	NN
cord-006860-a3b8hyyr	4794	16	where	where	WRB
cord-006860-a3b8hyyr	4794	17	destabilization	destabilization	NN
cord-006860-a3b8hyyr	4794	18	of	of	IN
cord-006860-a3b8hyyr	4794	19	the	the	DT
cord-006860-a3b8hyyr	4794	20	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4794	21	balance	balance	NN
cord-006860-a3b8hyyr	4794	22	and	and	CC
cord-006860-a3b8hyyr	4794	23	subsequent	subsequent	JJ
cord-006860-a3b8hyyr	4794	24	thrombus	thrombus	NN
cord-006860-a3b8hyyr	4794	25	formation	formation	NN
cord-006860-a3b8hyyr	4794	26	could	could	MD
cord-006860-a3b8hyyr	4794	27	occur	occur	VB
cord-006860-a3b8hyyr	4794	28	.	.	.
cord-006860-a3b8hyyr	4795	1	Institute	Institute	NNP
cord-006860-a3b8hyyr	4795	2	for	for	IN
cord-006860-a3b8hyyr	4795	3	Clinical	Clinical	NNP
cord-006860-a3b8hyyr	4795	4	Chemistry	Chemistry	NNP
cord-006860-a3b8hyyr	4795	5	and	and	CC
cord-006860-a3b8hyyr	4795	6	Laboratory	Laboratory	NNP
cord-006860-a3b8hyyr	4795	7	Diagnostics	Diagnostics	NNPS
cord-006860-a3b8hyyr	4795	8	and	and	CC
cord-006860-a3b8hyyr	4795	9	*	*	NFP
cord-006860-a3b8hyyr	4795	10	Clinic	Clinic	NNP
cord-006860-a3b8hyyr	4795	11	for	for	IN
cord-006860-a3b8hyyr	4795	12	Cardiology	Cardiology	NNP
cord-006860-a3b8hyyr	4795	13	,	,	,
cord-006860-a3b8hyyr	4795	14	Universi	Universi	NNP
cord-006860-a3b8hyyr	4795	15	W	W	NNP
cord-006860-a3b8hyyr	4795	16	of	of	IN
cord-006860-a3b8hyyr	4795	17	Duesseldorf	Duesseldorf	NNP
cord-006860-a3b8hyyr	4795	18	P	P	NNP
cord-006860-a3b8hyyr	4795	19	-	-	HYPH
cord-006860-a3b8hyyr	4795	20	selectin	selectin	NNP
cord-006860-a3b8hyyr	4795	21	(	(	-LRB-
cord-006860-a3b8hyyr	4795	22	CD	CD	NNP
cord-006860-a3b8hyyr	4795	23	62p	62p	NNPS
cord-006860-a3b8hyyr	4795	24	,	,	,
cord-006860-a3b8hyyr	4795	25	the	the	DT
cord-006860-a3b8hyyr	4795	26	former	former	JJ
cord-006860-a3b8hyyr	4795	27	granule	granule	NN
cord-006860-a3b8hyyr	4795	28	membrane	membrane	NN
cord-006860-a3b8hyyr	4795	29	protein	protein	NN
cord-006860-a3b8hyyr	4795	30	140	140	CD
cord-006860-a3b8hyyr	4795	31	or	or	CC
cord-006860-a3b8hyyr	4795	32	GMP	GMP	NNP
cord-006860-a3b8hyyr	4795	33	140	140	CD
cord-006860-a3b8hyyr	4795	34	)	)	-RRB-
cord-006860-a3b8hyyr	4795	35	is	be	VBZ
cord-006860-a3b8hyyr	4795	36	an	an	DT
cord-006860-a3b8hyyr	4795	37	integrated	integrated	JJ
cord-006860-a3b8hyyr	4795	38	membrane	membrane	NN
cord-006860-a3b8hyyr	4795	39	protein	protein	NN
cord-006860-a3b8hyyr	4795	40	of	of	IN
cord-006860-a3b8hyyr	4795	41	platelets	platelet	NNS
cord-006860-a3b8hyyr	4795	42	and	and	CC
cord-006860-a3b8hyyr	4795	43	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4795	44	cells	cell	NNS
cord-006860-a3b8hyyr	4795	45	.	.	.
cord-006860-a3b8hyyr	4796	1	Under	under	IN
cord-006860-a3b8hyyr	4796	2	inactivated	inactivate	VBN
cord-006860-a3b8hyyr	4796	3	conditions	condition	NNS
cord-006860-a3b8hyyr	4796	4	it	-PRON-	PRP
cord-006860-a3b8hyyr	4796	5	is	be	VBZ
cord-006860-a3b8hyyr	4796	6	stored	store	VBN
cord-006860-a3b8hyyr	4796	7	in	in	IN
cord-006860-a3b8hyyr	4796	8	the	the	DT
cord-006860-a3b8hyyr	4796	9	alpha	alpha	NN
cord-006860-a3b8hyyr	4796	10	granules	granule	NNS
cord-006860-a3b8hyyr	4796	11	of	of	IN
cord-006860-a3b8hyyr	4796	12	platelets	platelet	NNS
cord-006860-a3b8hyyr	4796	13	and	and	CC
cord-006860-a3b8hyyr	4796	14	in	in	IN
cord-006860-a3b8hyyr	4796	15	the	the	DT
cord-006860-a3b8hyyr	4796	16	WeibeI	weibei	JJ
cord-006860-a3b8hyyr	4796	17	-	-	HYPH
cord-006860-a3b8hyyr	4796	18	Palade	palade	JJ
cord-006860-a3b8hyyr	4796	19	bodies	body	NNS
cord-006860-a3b8hyyr	4796	20	of	of	IN
cord-006860-a3b8hyyr	4796	21	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4796	22	cells	cell	NNS
cord-006860-a3b8hyyr	4796	23	.	.	.
cord-006860-a3b8hyyr	4797	1	Endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4797	2	cells	cell	NNS
cord-006860-a3b8hyyr	4797	3	covering	cover	VBG
cord-006860-a3b8hyyr	4797	4	atherosclerotic	atherosclerotic	JJ
cord-006860-a3b8hyyr	4797	5	plaques	plaque	NNS
cord-006860-a3b8hyyr	4797	6	show	show	VBP
cord-006860-a3b8hyyr	4797	7	an	an	DT
cord-006860-a3b8hyyr	4797	8	increased	increase	VBN
cord-006860-a3b8hyyr	4797	9	expression	expression	NN
cord-006860-a3b8hyyr	4797	10	of	of	IN
cord-006860-a3b8hyyr	4797	11	P	p	NN
cord-006860-a3b8hyyr	4797	12	-	-	HYPH
cord-006860-a3b8hyyr	4797	13	selectin	selectin	NNP
cord-006860-a3b8hyyr	4797	14	.	.	.
cord-006860-a3b8hyyr	4798	1	13-thromboglobulin	13-thromboglobulin	CD
cord-006860-a3b8hyyr	4798	2	(	(	-LRB-
cord-006860-a3b8hyyr	4798	3	13-TG	13-tg	CD
cord-006860-a3b8hyyr	4798	4	)	)	-RRB-
cord-006860-a3b8hyyr	4798	5	,	,	,
cord-006860-a3b8hyyr	4798	6	which	which	WDT
cord-006860-a3b8hyyr	4798	7	is	be	VBZ
cord-006860-a3b8hyyr	4798	8	also	also	RB
cord-006860-a3b8hyyr	4798	9	expressed	express	VBN
cord-006860-a3b8hyyr	4798	10	from	from	IN
cord-006860-a3b8hyyr	4798	11	the	the	DT
cord-006860-a3b8hyyr	4798	12	alpha	alpha	NN
cord-006860-a3b8hyyr	4798	13	granules	granule	NNS
cord-006860-a3b8hyyr	4798	14	of	of	IN
cord-006860-a3b8hyyr	4798	15	platelets	platelet	NNS
cord-006860-a3b8hyyr	4798	16	during	during	IN
cord-006860-a3b8hyyr	4798	17	adhesion	adhesion	NN
cord-006860-a3b8hyyr	4798	18	or	or	CC
cord-006860-a3b8hyyr	4798	19	aggregation	aggregation	NN
cord-006860-a3b8hyyr	4798	20	,	,	,
cord-006860-a3b8hyyr	4798	21	is	be	VBZ
cord-006860-a3b8hyyr	4798	22	regarded	regard	VBN
cord-006860-a3b8hyyr	4798	23	as	as	IN
cord-006860-a3b8hyyr	4798	24	a	a	DT
cord-006860-a3b8hyyr	4798	25	marker	marker	NN
cord-006860-a3b8hyyr	4798	26	of	of	IN
cord-006860-a3b8hyyr	4798	27	platelet	platelet	NN
cord-006860-a3b8hyyr	4798	28	activation	activation	NN
cord-006860-a3b8hyyr	4798	29	in	in	IN
cord-006860-a3b8hyyr	4798	30	vivo	vivo	NNP
cord-006860-a3b8hyyr	4798	31	.	.	.
cord-006860-a3b8hyyr	4799	1	Coronary	coronary	JJ
cord-006860-a3b8hyyr	4799	2	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	4799	3	plays	play	VBZ
cord-006860-a3b8hyyr	4799	4	a	a	DT
cord-006860-a3b8hyyr	4799	5	central	central	JJ
cord-006860-a3b8hyyr	4799	6	role	role	NN
cord-006860-a3b8hyyr	4799	7	in	in	IN
cord-006860-a3b8hyyr	4799	8	the	the	DT
cord-006860-a3b8hyyr	4799	9	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	4799	10	of	of	IN
cord-006860-a3b8hyyr	4799	11	acute	acute	JJ
cord-006860-a3b8hyyr	4799	12	coronary	coronary	JJ
cord-006860-a3b8hyyr	4799	13	syndromes	syndrome	NNS
cord-006860-a3b8hyyr	4799	14	.	.	.
cord-006860-a3b8hyyr	4800	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4800	2	therefore	therefore	RB
cord-006860-a3b8hyyr	4800	3	analysed	analyse	VBD
cord-006860-a3b8hyyr	4800	4	CD	CD	NNP
cord-006860-a3b8hyyr	4800	5	62p	62p	NN
cord-006860-a3b8hyyr	4800	6	and	and	CC
cord-006860-a3b8hyyr	4800	7	13-TG	13-tg	CD
cord-006860-a3b8hyyr	4800	8	in	in	IN
cord-006860-a3b8hyyr	4800	9	acute	acute	JJ
cord-006860-a3b8hyyr	4800	10	coronary	coronary	JJ
cord-006860-a3b8hyyr	4800	11	syndromes	syndrome	NNS
cord-006860-a3b8hyyr	4800	12	,	,	,
cord-006860-a3b8hyyr	4800	13	healthy	healthy	JJ
cord-006860-a3b8hyyr	4800	14	subjects	subject	NNS
cord-006860-a3b8hyyr	4800	15	(	(	-LRB-
cord-006860-a3b8hyyr	4800	16	HS	HS	NNP
cord-006860-a3b8hyyr	4800	17	,	,	,
cord-006860-a3b8hyyr	4801	1	n	n	NNP
cord-006860-a3b8hyyr	4802	1	=	=	NFP
cord-006860-a3b8hyyr	4802	2	l	l	NNP
cord-006860-a3b8hyyr	4802	3	I	I	NNP
cord-006860-a3b8hyyr	4802	4	)	)	-RRB-
cord-006860-a3b8hyyr	4802	5	,	,	,
cord-006860-a3b8hyyr	4802	6	patients	patient	NNS
cord-006860-a3b8hyyr	4802	7	with	with	IN
cord-006860-a3b8hyyr	4802	8	stable	stable	JJ
cord-006860-a3b8hyyr	4802	9	angina	angina	JJ
cord-006860-a3b8hyyr	4802	10	pectoris	pectoris	NN
cord-006860-a3b8hyyr	4802	11	(	(	-LRB-
cord-006860-a3b8hyyr	4802	12	sAP	sAP	NNP
cord-006860-a3b8hyyr	4802	13	,	,	,
cord-006860-a3b8hyyr	4802	14	n=20	n=20	NNP
cord-006860-a3b8hyyr	4802	15	)	)	-RRB-
cord-006860-a3b8hyyr	4802	16	,	,	,
cord-006860-a3b8hyyr	4802	17	unstable	unstable	JJ
cord-006860-a3b8hyyr	4802	18	angina	angina	NN
cord-006860-a3b8hyyr	4802	19	pectoris	pectoris	NN
cord-006860-a3b8hyyr	4802	20	(	(	-LRB-
cord-006860-a3b8hyyr	4802	21	uAP	uAP	NNP
cord-006860-a3b8hyyr	4802	22	,	,	,
cord-006860-a3b8hyyr	4802	23	n	n	NN
cord-006860-a3b8hyyr	4802	24	=	=	SYM
cord-006860-a3b8hyyr	4802	25	l	l	NN
cord-006860-a3b8hyyr	4802	26	2	2	CD
cord-006860-a3b8hyyr	4802	27	)	)	-RRB-
cord-006860-a3b8hyyr	4802	28	and	and	CC
cord-006860-a3b8hyyr	4802	29	acute	acute	JJ
cord-006860-a3b8hyyr	4802	30	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	4802	31	infarction	infarction	NN
cord-006860-a3b8hyyr	4802	32	(	(	-LRB-
cord-006860-a3b8hyyr	4802	33	AMI	AMI	NNP
cord-006860-a3b8hyyr	4802	34	,	,	,
cord-006860-a3b8hyyr	4802	35	n=	n=	NNP
cord-006860-a3b8hyyr	4802	36	12	12	CD
cord-006860-a3b8hyyr	4802	37	)	)	-RRB-
cord-006860-a3b8hyyr	4802	38	.	.	.
cord-006860-a3b8hyyr	4803	1	Plasma	plasma	NN
cord-006860-a3b8hyyr	4803	2	samples	sample	NNS
cord-006860-a3b8hyyr	4803	3	were	be	VBD
cord-006860-a3b8hyyr	4803	4	obtained	obtain	VBN
cord-006860-a3b8hyyr	4803	5	by	by	IN
cord-006860-a3b8hyyr	4803	6	using	use	VBG
cord-006860-a3b8hyyr	4803	7	CTAD	CTAD	NNP
cord-006860-a3b8hyyr	4803	8	Vacutainer	Vacutainer	NNP
cord-006860-a3b8hyyr	4803	9	tubes	tube	NNS
cord-006860-a3b8hyyr	4803	10	(	(	-LRB-
cord-006860-a3b8hyyr	4803	11	0.109	0.109	CD
cord-006860-a3b8hyyr	4803	12	M	M	NNP
cord-006860-a3b8hyyr	4803	13	Na~-citrate	Na~-citrate	NNP
cord-006860-a3b8hyyr	4803	14	,	,	,
cord-006860-a3b8hyyr	4803	15	theophylline	theophylline	NN
cord-006860-a3b8hyyr	4803	16	,	,	,
cord-006860-a3b8hyyr	4803	17	adenosine	adenosine	NN
cord-006860-a3b8hyyr	4803	18	dipyridamole	dipyridamole	NN
cord-006860-a3b8hyyr	4803	19	)	)	-RRB-
cord-006860-a3b8hyyr	4803	20	.	.	.
cord-006860-a3b8hyyr	4804	1	Patients	patient	NNS
cord-006860-a3b8hyyr	4804	2	with	with	IN
cord-006860-a3b8hyyr	4804	3	CAD	CAD	NNP
cord-006860-a3b8hyyr	4804	4	showed	show	VBD
cord-006860-a3b8hyyr	4804	5	significantly	significantly	RB
cord-006860-a3b8hyyr	4804	6	increased	increase	VBN
cord-006860-a3b8hyyr	4804	7	plasma	plasma	NN
cord-006860-a3b8hyyr	4804	8	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4804	9	of	of	IN
cord-006860-a3b8hyyr	4804	10	CD	cd	NN
cord-006860-a3b8hyyr	4804	11	62p	62p	CD
cord-006860-a3b8hyyr	4805	1	(	(	-LRB-
cord-006860-a3b8hyyr	4805	2	HS	HS	NNP
cord-006860-a3b8hyyr	4805	3	:	:	:
cord-006860-a3b8hyyr	4806	1	98	98	CD
cord-006860-a3b8hyyr	4806	2	+	+	SYM
cord-006860-a3b8hyyr	4806	3	20	20	CD
cord-006860-a3b8hyyr	4806	4	versus	versus	IN
cord-006860-a3b8hyyr	4806	5	sAP	sAP	NNP
cord-006860-a3b8hyyr	4806	6	:	:	:
cord-006860-a3b8hyyr	4807	1	133	133	CD
cord-006860-a3b8hyyr	4807	2	+	+	SYM
cord-006860-a3b8hyyr	4807	3	38ng	38ng	NN
cord-006860-a3b8hyyr	4807	4	/	/	SYM
cord-006860-a3b8hyyr	4807	5	ml	ml	NN
cord-006860-a3b8hyyr	4807	6	,	,	,
cord-006860-a3b8hyyr	4807	7	p<0.05	p<0.05	CD
cord-006860-a3b8hyyr	4807	8	;	;	.
cord-006860-a3b8hyyr	4808	1	versus	versus	IN
cord-006860-a3b8hyyr	4808	2	uAP	uAP	NNP
cord-006860-a3b8hyyr	4808	3	:	:	:
cord-006860-a3b8hyyr	4808	4	128	128	CD
cord-006860-a3b8hyyr	4808	5	+	+	SYM
cord-006860-a3b8hyyr	4808	6	28	28	CD
cord-006860-a3b8hyyr	4808	7	ng	ng	NN
cord-006860-a3b8hyyr	4808	8	/	/	SYM
cord-006860-a3b8hyyr	4808	9	ml	ml	NN
cord-006860-a3b8hyyr	4808	10	,	,	,
cord-006860-a3b8hyyr	4808	11	p<0.01	p<0.01	NNP
cord-006860-a3b8hyyr	4808	12	;	;	:
cord-006860-a3b8hyyr	4808	13	versus	versus	IN
cord-006860-a3b8hyyr	4808	14	AMI	AMI	NNP
cord-006860-a3b8hyyr	4808	15	:	:	:
cord-006860-a3b8hyyr	4808	16	144	144	CD
cord-006860-a3b8hyyr	4808	17	+	+	SYM
cord-006860-a3b8hyyr	4808	18	72	72	CD
cord-006860-a3b8hyyr	4808	19	ng	ng	NN
cord-006860-a3b8hyyr	4808	20	/	/	SYM
cord-006860-a3b8hyyr	4808	21	ml	ml	XX
cord-006860-a3b8hyyr	4808	22	,	,	,
cord-006860-a3b8hyyr	4809	1	p<0.05	p<0.05	NNP
cord-006860-a3b8hyyr	4809	2	)	)	-RRB-
cord-006860-a3b8hyyr	4809	3	independent	independent	NN
cord-006860-a3b8hyyr	4809	4	of	of	IN
cord-006860-a3b8hyyr	4809	5	the	the	DT
cord-006860-a3b8hyyr	4809	6	severity	severity	NN
cord-006860-a3b8hyyr	4809	7	of	of	IN
cord-006860-a3b8hyyr	4809	8	clinical	clinical	JJ
cord-006860-a3b8hyyr	4809	9	symptoms	symptom	NNS
cord-006860-a3b8hyyr	4809	10	.	.	.
cord-006860-a3b8hyyr	4810	1	In	in	IN
cord-006860-a3b8hyyr	4810	2	comparison	comparison	NN
cord-006860-a3b8hyyr	4810	3	only	only	RB
cord-006860-a3b8hyyr	4810	4	patients	patient	NNS
cord-006860-a3b8hyyr	4810	5	with	with	IN
cord-006860-a3b8hyyr	4810	6	AMI	AMI	NNP
cord-006860-a3b8hyyr	4810	7	showed	show	VBD
cord-006860-a3b8hyyr	4810	8	significant	significant	JJ
cord-006860-a3b8hyyr	4810	9	higher	high	JJR
cord-006860-a3b8hyyr	4810	10	8-TG	8-tg	CD
cord-006860-a3b8hyyr	4810	11	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4810	12	compared	compare	VBN
cord-006860-a3b8hyyr	4810	13	with	with	IN
cord-006860-a3b8hyyr	4810	14	HS	HS	NNP
cord-006860-a3b8hyyr	4810	15	(	(	-LRB-
cord-006860-a3b8hyyr	4810	16	HS	HS	NNP
cord-006860-a3b8hyyr	4810	17	:	:	:
cord-006860-a3b8hyyr	4810	18	30	30	CD
cord-006860-a3b8hyyr	4810	19	+	+	SYM
cord-006860-a3b8hyyr	4810	20	20	20	CD
cord-006860-a3b8hyyr	4810	21	versus	versus	IN
cord-006860-a3b8hyyr	4810	22	AMI	AMI	NNP
cord-006860-a3b8hyyr	4810	23	:	:	:
cord-006860-a3b8hyyr	4810	24	39	39	CD
cord-006860-a3b8hyyr	4810	25	+	+	SYM
cord-006860-a3b8hyyr	4810	26	14ng	14ng	NN
cord-006860-a3b8hyyr	4810	27	/	/	SYM
cord-006860-a3b8hyyr	4810	28	ml	ml	NN
cord-006860-a3b8hyyr	4810	29	,	,	,
cord-006860-a3b8hyyr	4810	30	p<0.05	p<0.05	CD
cord-006860-a3b8hyyr	4810	31	)	)	-RRB-
cord-006860-a3b8hyyr	4810	32	.	.	.
cord-006860-a3b8hyyr	4811	1	Although	although	IN
cord-006860-a3b8hyyr	4811	2	the	the	DT
cord-006860-a3b8hyyr	4811	3	CD	CD	NNP
cord-006860-a3b8hyyr	4811	4	62p	62p	NNS
cord-006860-a3b8hyyr	4811	5	plasma	plasma	NN
cord-006860-a3b8hyyr	4811	6	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4811	7	showed	show	VBD
cord-006860-a3b8hyyr	4811	8	no	no	DT
cord-006860-a3b8hyyr	4811	9	relationship	relationship	NN
cord-006860-a3b8hyyr	4811	10	to	to	IN
cord-006860-a3b8hyyr	4811	11	the	the	DT
cord-006860-a3b8hyyr	4811	12	clinical	clinical	JJ
cord-006860-a3b8hyyr	4811	13	severity	severity	NN
cord-006860-a3b8hyyr	4811	14	,	,	,
cord-006860-a3b8hyyr	4811	15	hence	hence	RB
cord-006860-a3b8hyyr	4811	16	there	there	EX
cord-006860-a3b8hyyr	4811	17	was	be	VBD
cord-006860-a3b8hyyr	4811	18	a	a	DT
cord-006860-a3b8hyyr	4811	19	positive	positive	JJ
cord-006860-a3b8hyyr	4811	20	correlation	correlation	NN
cord-006860-a3b8hyyr	4811	21	between	between	IN
cord-006860-a3b8hyyr	4811	22	CD	cd	NN
cord-006860-a3b8hyyr	4811	23	62p	62p	CD
cord-006860-a3b8hyyr	4812	1	(	(	-LRB-
cord-006860-a3b8hyyr	4812	2	r=0.47	r=0.47	NN
cord-006860-a3b8hyyr	4812	3	;	;	:
cord-006860-a3b8hyyr	4812	4	p	p	NN
cord-006860-a3b8hyyr	4812	5	<	<	XX
cord-006860-a3b8hyyr	4812	6	0.001	0.001	CD
cord-006860-a3b8hyyr	4812	7	;	;	:
cord-006860-a3b8hyyr	4812	8	n=55	n=55	NNP
cord-006860-a3b8hyyr	4812	9	)	)	-RRB-
cord-006860-a3b8hyyr	4812	10	to	to	IN
cord-006860-a3b8hyyr	4812	11	the	the	DT
cord-006860-a3b8hyyr	4812	12	severity	severity	NN
cord-006860-a3b8hyyr	4812	13	of	of	IN
cord-006860-a3b8hyyr	4812	14	CAD	CAD	NNP
cord-006860-a3b8hyyr	4812	15	classified	classify	VBN
cord-006860-a3b8hyyr	4812	16	as	as	IN
cord-006860-a3b8hyyr	4812	17	I	-PRON-	PRP
cord-006860-a3b8hyyr	4812	18	,	,	,
cord-006860-a3b8hyyr	4812	19	2	2	CD
cord-006860-a3b8hyyr	4812	20	,	,	,
cord-006860-a3b8hyyr	4812	21	3	3	CD
cord-006860-a3b8hyyr	4812	22	vessel	vessel	NN
cord-006860-a3b8hyyr	4812	23	disease	disease	NN
cord-006860-a3b8hyyr	4812	24	.	.	.
cord-006860-a3b8hyyr	4813	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	4813	2	is	be	VBZ
cord-006860-a3b8hyyr	4813	3	concluded	conclude	VBN
cord-006860-a3b8hyyr	4813	4	that	that	IN
cord-006860-a3b8hyyr	4813	5	elevated	elevated	JJ
cord-006860-a3b8hyyr	4813	6	CD	cd	NN
cord-006860-a3b8hyyr	4813	7	62p	62p	CD
cord-006860-a3b8hyyr	4813	8	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4813	9	are	be	VBP
cord-006860-a3b8hyyr	4813	10	correlated	correlate	VBN
cord-006860-a3b8hyyr	4813	11	with	with	IN
cord-006860-a3b8hyyr	4813	12	the	the	DT
cord-006860-a3b8hyyr	4813	13	severity	severity	NN
cord-006860-a3b8hyyr	4813	14	of	of	IN
cord-006860-a3b8hyyr	4813	15	cardiovascular	cardiovascular	JJ
cord-006860-a3b8hyyr	4813	16	disease	disease	NN
cord-006860-a3b8hyyr	4813	17	.	.	.
cord-006860-a3b8hyyr	4814	1	CD	CD	NNP
cord-006860-a3b8hyyr	4814	2	62p	62p	CD
cord-006860-a3b8hyyr	4814	3	is	be	VBZ
cord-006860-a3b8hyyr	4814	4	not	not	RB
cord-006860-a3b8hyyr	4814	5	suitable	suitable	JJ
cord-006860-a3b8hyyr	4814	6	for	for	IN
cord-006860-a3b8hyyr	4814	7	differential	differential	JJ
cord-006860-a3b8hyyr	4814	8	diagnosis	diagnosis	NN
cord-006860-a3b8hyyr	4814	9	of	of	IN
cord-006860-a3b8hyyr	4814	10	acute	acute	JJ
cord-006860-a3b8hyyr	4814	11	coronary	coronary	JJ
cord-006860-a3b8hyyr	4814	12	syndromes	syndrome	NNS
cord-006860-a3b8hyyr	4814	13	,	,	,
cord-006860-a3b8hyyr	4814	14	because	because	IN
cord-006860-a3b8hyyr	4814	15	it	-PRON-	PRP
cord-006860-a3b8hyyr	4814	16	is	be	VBZ
cord-006860-a3b8hyyr	4814	17	elevated	elevate	VBN
cord-006860-a3b8hyyr	4814	18	independently	independently	RB
cord-006860-a3b8hyyr	4814	19	of	of	IN
cord-006860-a3b8hyyr	4814	20	the	the	DT
cord-006860-a3b8hyyr	4814	21	clinical	clinical	JJ
cord-006860-a3b8hyyr	4814	22	status	status	NN
cord-006860-a3b8hyyr	4814	23	of	of	IN
cord-006860-a3b8hyyr	4814	24	the	the	DT
cord-006860-a3b8hyyr	4814	25	patients	patient	NNS
cord-006860-a3b8hyyr	4814	26	.	.	.
cord-006860-a3b8hyyr	4815	1	The	the	DT
cord-006860-a3b8hyyr	4815	2	involvement	involvement	NN
cord-006860-a3b8hyyr	4815	3	of	of	IN
cord-006860-a3b8hyyr	4815	4	platelets	platelet	NNS
cord-006860-a3b8hyyr	4815	5	in	in	IN
cord-006860-a3b8hyyr	4815	6	the	the	DT
cord-006860-a3b8hyyr	4815	7	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	4815	8	of	of	IN
cord-006860-a3b8hyyr	4815	9	acute	acute	JJ
cord-006860-a3b8hyyr	4815	10	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	4815	11	infarction	infarction	NN
cord-006860-a3b8hyyr	4815	12	may	may	MD
cord-006860-a3b8hyyr	4815	13	be	be	VB
cord-006860-a3b8hyyr	4815	14	indicated	indicate	VBN
cord-006860-a3b8hyyr	4815	15	by	by	IN
cord-006860-a3b8hyyr	4815	16	the	the	DT
cord-006860-a3b8hyyr	4815	17	increased	increase	VBN
cord-006860-a3b8hyyr	4815	18	13-TG	13-tg	CD
cord-006860-a3b8hyyr	4815	19	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4815	20	.	.	.
cord-006860-a3b8hyyr	4816	1	IKlinik	IKlinik	NNP
cord-006860-a3b8hyyr	4817	1	Nr	Nr	NNP
cord-006860-a3b8hyyr	4817	2	Herz-	Herz-	NNP
cord-006860-a3b8hyyr	4818	1	,	,	,
cord-006860-a3b8hyyr	4818	2	Thorax	Thorax	NNP
cord-006860-a3b8hyyr	4818	3	-	-	HYPH
cord-006860-a3b8hyyr	4818	4	und	und	NNP
cord-006860-a3b8hyyr	4818	5	herznahe	herznahe	NNP
cord-006860-a3b8hyyr	4818	6	Gef&Schirurgie	Gef&Schirurgie	NNP
cord-006860-a3b8hyyr	4818	7	und	und	XX
cord-006860-a3b8hyyr	4819	1	2Institut	2institut	LS
cord-006860-a3b8hyyr	4819	2	x	x	SYM
cord-006860-a3b8hyyr	4819	3	~	~	CD
cord-006860-a3b8hyyr	4819	4	tr	tr	NNP
cord-006860-a3b8hyyr	4819	5	Klinische	Klinische	NNP
cord-006860-a3b8hyyr	4819	6	Chemie	Chemie	NNP
cord-006860-a3b8hyyr	4819	7	und	und	IN
cord-006860-a3b8hyyr	4819	8	Laberatodumsmedizin	Laberatodumsmedizin	NNP
cord-006860-a3b8hyyr	4819	9	der	der	NNP
cord-006860-a3b8hyyr	4819	10	UniversiNt	UniversiNt	NNP
cord-006860-a3b8hyyr	4820	1	Regensburg	Regensburg	NNP
cord-006860-a3b8hyyr	4820	2	An	an	DT
cord-006860-a3b8hyyr	4820	3	increased	increase	VBN
cord-006860-a3b8hyyr	4820	4	blood	blood	NN
cord-006860-a3b8hyyr	4820	5	loss	loss	NN
cord-006860-a3b8hyyr	4820	6	following	follow	VBG
cord-006860-a3b8hyyr	4820	7	surgery	surgery	NN
cord-006860-a3b8hyyr	4820	8	with	with	IN
cord-006860-a3b8hyyr	4820	9	extracorporeal	extracorporeal	JJ
cord-006860-a3b8hyyr	4820	10	circulation	circulation	NN
cord-006860-a3b8hyyr	4820	11	(	(	-LRB-
cord-006860-a3b8hyyr	4820	12	ECC	ECC	NNP
cord-006860-a3b8hyyr	4820	13	)	)	-RRB-
cord-006860-a3b8hyyr	4820	14	contributes	contribute	VBZ
cord-006860-a3b8hyyr	4820	15	to	to	IN
cord-006860-a3b8hyyr	4820	16	the	the	DT
cord-006860-a3b8hyyr	4820	17	morbidity	morbidity	NN
cord-006860-a3b8hyyr	4820	18	and	and	CC
cord-006860-a3b8hyyr	4820	19	mortality	mortality	NN
cord-006860-a3b8hyyr	4820	20	.	.	.
cord-006860-a3b8hyyr	4821	1	Postoperative	postoperative	JJ
cord-006860-a3b8hyyr	4821	2	haemorrhage	haemorrhage	NN
cord-006860-a3b8hyyr	4821	3	following	follow	VBG
cord-006860-a3b8hyyr	4821	4	ECC	ECC	NNP
cord-006860-a3b8hyyr	4821	5	has	have	VBZ
cord-006860-a3b8hyyr	4821	6	been	be	VBN
cord-006860-a3b8hyyr	4821	7	related	relate	VBN
cord-006860-a3b8hyyr	4821	8	to	to	IN
cord-006860-a3b8hyyr	4821	9	a	a	DT
cord-006860-a3b8hyyr	4821	10	platelet	platelet	NN
cord-006860-a3b8hyyr	4821	11	function	function	NN
cord-006860-a3b8hyyr	4821	12	defect	defect	NN
cord-006860-a3b8hyyr	4821	13	and	and	CC
cord-006860-a3b8hyyr	4821	14	the	the	DT
cord-006860-a3b8hyyr	4821	15	activation	activation	NN
cord-006860-a3b8hyyr	4821	16	of	of	IN
cord-006860-a3b8hyyr	4821	17	the	the	DT
cord-006860-a3b8hyyr	4821	18	blood	blood	NN
cord-006860-a3b8hyyr	4821	19	dotting	dotting	NN
cord-006860-a3b8hyyr	4821	20	and	and	CC
cord-006860-a3b8hyyr	4821	21	fibrinulytic	fibrinulytic	JJ
cord-006860-a3b8hyyr	4821	22	system	system	NN
cord-006860-a3b8hyyr	4821	23	.	.	.
cord-006860-a3b8hyyr	4822	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4822	2	investigated	investigate	VBD
cord-006860-a3b8hyyr	4822	3	platelet	platelet	NN
cord-006860-a3b8hyyr	4822	4	surface	surface	NN
cord-006860-a3b8hyyr	4822	5	antigen	antigen	NN
cord-006860-a3b8hyyr	4822	6	expression	expression	NN
cord-006860-a3b8hyyr	4822	7	and	and	CC
cord-006860-a3b8hyyr	4822	8	parameters	parameter	NNS
cord-006860-a3b8hyyr	4822	9	indicating	indicate	VBG
cord-006860-a3b8hyyr	4822	10	activation	activation	NN
cord-006860-a3b8hyyr	4822	11	of	of	IN
cord-006860-a3b8hyyr	4822	12	the	the	DT
cord-006860-a3b8hyyr	4822	13	clotting	clotting	NN
cord-006860-a3b8hyyr	4822	14	and	and	CC
cord-006860-a3b8hyyr	4822	15	fibrinolytic	fibrinolytic	NN
cord-006860-a3b8hyyr	4822	16	cascade	cascade	NN
cord-006860-a3b8hyyr	4822	17	to	to	TO
cord-006860-a3b8hyyr	4822	18	assess	assess	VB
cord-006860-a3b8hyyr	4822	19	the	the	DT
cord-006860-a3b8hyyr	4822	20	predictive	predictive	JJ
cord-006860-a3b8hyyr	4822	21	potential	potential	NN
cord-006860-a3b8hyyr	4822	22	of	of	IN
cord-006860-a3b8hyyr	4822	23	these	these	DT
cord-006860-a3b8hyyr	4822	24	variables	variable	NNS
cord-006860-a3b8hyyr	4822	25	for	for	IN
cord-006860-a3b8hyyr	4822	26	increased	increase	VBN
cord-006860-a3b8hyyr	4822	27	blood	blood	NN
cord-006860-a3b8hyyr	4822	28	loss	loss	NN
cord-006860-a3b8hyyr	4822	29	after	after	IN
cord-006860-a3b8hyyr	4822	30	ECC	ECC	NNP
cord-006860-a3b8hyyr	4822	31	.	.	.
cord-006860-a3b8hyyr	4823	1	g0	g0	NNP
cord-006860-a3b8hyyr	4823	2	patients	patient	NNS
cord-006860-a3b8hyyr	4823	3	referred	refer	VBD
cord-006860-a3b8hyyr	4823	4	for	for	IN
cord-006860-a3b8hyyr	4823	5	coronary	coronary	JJ
cord-006860-a3b8hyyr	4823	6	bypass	bypass	NN
cord-006860-a3b8hyyr	4823	7	gra	gra	NNP
cord-006860-a3b8hyyr	4823	8	~	~	NFP
cord-006860-a3b8hyyr	4823	9	ing	e	VBG
cord-006860-a3b8hyyr	4823	10	with	with	IN
cord-006860-a3b8hyyr	4823	11	no	no	DT
cord-006860-a3b8hyyr	4823	12	history	history	NN
cord-006860-a3b8hyyr	4823	13	of	of	IN
cord-006860-a3b8hyyr	4823	14	a	a	DT
cord-006860-a3b8hyyr	4823	15	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4823	16	disorder	disorder	NN
cord-006860-a3b8hyyr	4823	17	and	and	CC
cord-006860-a3b8hyyr	4823	18	normal	normal	JJ
cord-006860-a3b8hyyr	4823	19	routine	routine	JJ
cord-006860-a3b8hyyr	4823	20	clotting	clotting	NN
cord-006860-a3b8hyyr	4823	21	tests	test	NNS
cord-006860-a3b8hyyr	4823	22	were	be	VBD
cord-006860-a3b8hyyr	4823	23	included	include	VBN
cord-006860-a3b8hyyr	4823	24	.	.	.
cord-006860-a3b8hyyr	4824	1	On	on	IN
cord-006860-a3b8hyyr	4824	2	the	the	DT
cord-006860-a3b8hyyr	4824	3	day	day	NN
cord-006860-a3b8hyyr	4824	4	prior	prior	RB
cord-006860-a3b8hyyr	4824	5	to	to	IN
cord-006860-a3b8hyyr	4824	6	surge~	surge~	NN
cord-006860-a3b8hyyr	4824	7	and	and	CC
cord-006860-a3b8hyyr	4824	8	immediately	immediately	RB
cord-006860-a3b8hyyr	4824	9	upon	upon	IN
cord-006860-a3b8hyyr	4824	10	arrival	arrival	NN
cord-006860-a3b8hyyr	4824	11	on	on	IN
cord-006860-a3b8hyyr	4824	12	the	the	DT
cord-006860-a3b8hyyr	4824	13	intensive	intensive	JJ
cord-006860-a3b8hyyr	4824	14	care	care	NN
cord-006860-a3b8hyyr	4824	15	unit	unit	NN
cord-006860-a3b8hyyr	4824	16	blood	blood	NN
cord-006860-a3b8hyyr	4824	17	samples	sample	NNS
cord-006860-a3b8hyyr	4824	18	were	be	VBD
cord-006860-a3b8hyyr	4824	19	drawn	draw	VBN
cord-006860-a3b8hyyr	4824	20	.	.	.
cord-006860-a3b8hyyr	4825	1	The	the	DT
cord-006860-a3b8hyyr	4825	2	surface	surface	NN
cord-006860-a3b8hyyr	4825	3	expression	expression	NN
cord-006860-a3b8hyyr	4825	4	of	of	IN
cord-006860-a3b8hyyr	4825	5	glycoprotein	glycoprotein	NN
cord-006860-a3b8hyyr	4825	6	(	(	-LRB-
cord-006860-a3b8hyyr	4825	7	GP	GP	NNP
cord-006860-a3b8hyyr	4825	8	)	)	-RRB-
cord-006860-a3b8hyyr	4825	9	lib	lib	NN
cord-006860-a3b8hyyr	4825	10	-	-	HYPH
cord-006860-a3b8hyyr	4825	11	Ilia	Ilia	NNP
cord-006860-a3b8hyyr	4825	12	,	,	,
cord-006860-a3b8hyyr	4825	13	GP	GP	NNP
cord-006860-a3b8hyyr	4825	14	lb	lb	NN
cord-006860-a3b8hyyr	4825	15	,	,	,
cord-006860-a3b8hyyr	4825	16	and	and	CC
cord-006860-a3b8hyyr	4825	17	P	p	NN
cord-006860-a3b8hyyr	4825	18	-	-	HYPH
cord-006860-a3b8hyyr	4825	19	selectin	selectin	NNP
cord-006860-a3b8hyyr	4825	20	was	be	VBD
cord-006860-a3b8hyyr	4825	21	meamred	meamre	VBN
cord-006860-a3b8hyyr	4825	22	with	with	IN
cord-006860-a3b8hyyr	4825	23	and	and	CC
cord-006860-a3b8hyyr	4825	24	without	without	IN
cord-006860-a3b8hyyr	4825	25	in	in	IN
cord-006860-a3b8hyyr	4825	26	vitro	vitro	FW
cord-006860-a3b8hyyr	4825	27	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4825	28	with	with	IN
cord-006860-a3b8hyyr	4825	29	adenosine	adenosine	NN
cord-006860-a3b8hyyr	4825	30	diphosphate	diphosphate	NN
cord-006860-a3b8hyyr	4825	31	(	(	-LRB-
cord-006860-a3b8hyyr	4825	32	ADP	ADP	NNP
cord-006860-a3b8hyyr	4825	33	)	)	-RRB-
cord-006860-a3b8hyyr	4825	34	using	use	VBG
cord-006860-a3b8hyyr	4825	35	whole	whole	JJ
cord-006860-a3b8hyyr	4825	36	blood	blood	NN
cord-006860-a3b8hyyr	4825	37	flow	flow	NN
cord-006860-a3b8hyyr	4825	38	cytomet	cytomet	NNP
cord-006860-a3b8hyyr	4825	39	~	~	NFP
cord-006860-a3b8hyyr	4825	40	y	y	NN
cord-006860-a3b8hyyr	4825	41	.	.	.
cord-006860-a3b8hyyr	4826	1	Platelet	platelet	NN
cord-006860-a3b8hyyr	4826	2	counts	count	NNS
cord-006860-a3b8hyyr	4826	3	and	and	CC
cord-006860-a3b8hyyr	4826	4	platelet	platelet	NN
cord-006860-a3b8hyyr	4826	5	factor	factor	NN
cord-006860-a3b8hyyr	4826	6	4	4	CD
cord-006860-a3b8hyyr	4826	7	(	(	-LRB-
cord-006860-a3b8hyyr	4826	8	PF4	PF4	NNP
cord-006860-a3b8hyyr	4826	9	)	)	-RRB-
cord-006860-a3b8hyyr	4826	10	,	,	,
cord-006860-a3b8hyyr	4826	11	as	as	RB
cord-006860-a3b8hyyr	4826	12	well	well	RB
cord-006860-a3b8hyyr	4826	13	as	as	IN
cord-006860-a3b8hyyr	4826	14	,	,	,
cord-006860-a3b8hyyr	4826	15	routine	routine	JJ
cord-006860-a3b8hyyr	4826	16	clotting	clotting	NN
cord-006860-a3b8hyyr	4826	17	tests	test	NNS
cord-006860-a3b8hyyr	4826	18	were	be	VBD
cord-006860-a3b8hyyr	4826	19	performed	perform	VBN
cord-006860-a3b8hyyr	4826	20	.	.	.
cord-006860-a3b8hyyr	4827	1	Activation	activation	NN
cord-006860-a3b8hyyr	4827	2	of	of	IN
cord-006860-a3b8hyyr	4827	3	the	the	DT
cord-006860-a3b8hyyr	4827	4	clotting	clotting	NN
cord-006860-a3b8hyyr	4827	5	and	and	CC
cord-006860-a3b8hyyr	4827	6	fibrinolytic	fibrinolytic	JJ
cord-006860-a3b8hyyr	4827	7	system	system	NN
cord-006860-a3b8hyyr	4827	8	were	be	VBD
cord-006860-a3b8hyyr	4827	9	judged	judge	VBN
cord-006860-a3b8hyyr	4827	10	from	from	IN
cord-006860-a3b8hyyr	4827	11	thrombin	thrombin	NN
cord-006860-a3b8hyyr	4827	12	-	-	HYPH
cord-006860-a3b8hyyr	4827	13	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	4827	14	-	-	HYPH
cord-006860-a3b8hyyr	4827	15	III	III	NNP
cord-006860-a3b8hyyr	4827	16	complex	complex	JJ
cord-006860-a3b8hyyr	4827	17	fiAT	fiAT	NNP
cord-006860-a3b8hyyr	4827	18	)	)	-RRB-
cord-006860-a3b8hyyr	4827	19	,	,	,
cord-006860-a3b8hyyr	4827	20	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	4827	21	fiG	fiG	NNP
cord-006860-a3b8hyyr	4827	22	)	)	-RRB-
cord-006860-a3b8hyyr	4827	23	,	,	,
cord-006860-a3b8hyyr	4827	24	D	d	NN
cord-006860-a3b8hyyr	4827	25	-	-	HYPH
cord-006860-a3b8hyyr	4827	26	dimers	dimer	NNS
cord-006860-a3b8hyyr	4827	27	(	(	-LRB-
cord-006860-a3b8hyyr	4827	28	DD	DD	NNP
cord-006860-a3b8hyyr	4827	29	)	)	-RRB-
cord-006860-a3b8hyyr	4827	30	,	,	,
cord-006860-a3b8hyyr	4827	31	cc2-antiplasmin	cc2-antiplasmin	NNP
cord-006860-a3b8hyyr	4827	32	(	(	-LRB-
cord-006860-a3b8hyyr	4827	33	tz2A	tz2A	NNP
cord-006860-a3b8hyyr	4827	34	)	)	-RRB-
cord-006860-a3b8hyyr	4827	35	,	,	,
cord-006860-a3b8hyyr	4827	36	prothrombin	prothrombin	NN
cord-006860-a3b8hyyr	4827	37	fragment	fragment	NN
cord-006860-a3b8hyyr	4827	38	1	1	CD
cord-006860-a3b8hyyr	4827	39	+	+	SYM
cord-006860-a3b8hyyr	4827	40	2	2	CD
cord-006860-a3b8hyyr	4828	1	(	(	-LRB-
cord-006860-a3b8hyyr	4828	2	Fl+2),and	Fl+2),and	NNP
cord-006860-a3b8hyyr	4828	3	tissue	tissue	NN
cord-006860-a3b8hyyr	4829	1	plasm~	plasm~	NNP
cord-006860-a3b8hyyr	4829	2	activator	activator	NN
cord-006860-a3b8hyyr	4829	3	(	(	-LRB-
cord-006860-a3b8hyyr	4829	4	t	t	NNP
cord-006860-a3b8hyyr	4829	5	-	-	HYPH
cord-006860-a3b8hyyr	4829	6	PA	PA	NNP
cord-006860-a3b8hyyr	4829	7	)	)	-RRB-
cord-006860-a3b8hyyr	4829	8	.	.	.
cord-006860-a3b8hyyr	4830	1	Blood	blood	NN
cord-006860-a3b8hyyr	4830	2	loss	loss	NN
cord-006860-a3b8hyyr	4830	3	fxom	fxom	NN
cord-006860-a3b8hyyr	4830	4	chest	chest	NN
cord-006860-a3b8hyyr	4830	5	tubes	tube	NNS
cord-006860-a3b8hyyr	4830	6	was	be	VBD
cord-006860-a3b8hyyr	4830	7	measured	measure	VBN
cord-006860-a3b8hyyr	4830	8	hourly	hourly	RB
cord-006860-a3b8hyyr	4830	9	until	until	IN
cord-006860-a3b8hyyr	4830	10	removal	removal	NN
cord-006860-a3b8hyyr	4830	11	of	of	IN
cord-006860-a3b8hyyr	4830	12	drains	drain	NNS
cord-006860-a3b8hyyr	4830	13	.	.	.
cord-006860-a3b8hyyr	4831	1	Following	follow	VBG
cord-006860-a3b8hyyr	4831	2	ECC	ECC	NNP
cord-006860-a3b8hyyr	4831	3	the	the	DT
cord-006860-a3b8hyyr	4831	4	levels	level	NNS
cord-006860-a3b8hyyr	4831	5	of	of	IN
cord-006860-a3b8hyyr	4831	6	PF4	pf4	NN
cord-006860-a3b8hyyr	4831	7	,	,	,
cord-006860-a3b8hyyr	4831	8	TAT	tat	NN
cord-006860-a3b8hyyr	4831	9	,	,	,
cord-006860-a3b8hyyr	4831	10	DD	DD	NNP
cord-006860-a3b8hyyr	4831	11	,	,	,
cord-006860-a3b8hyyr	4831	12	o~2A	o~2A	NNP
cord-006860-a3b8hyyr	4831	13	,	,	,
cord-006860-a3b8hyyr	4831	14	Fl+2	Fl+2	NNP
cord-006860-a3b8hyyr	4831	15	,	,	,
cord-006860-a3b8hyyr	4831	16	and	and	CC
cord-006860-a3b8hyyr	4831	17	DD	DD	NNP
cord-006860-a3b8hyyr	4831	18	were	be	VBD
cord-006860-a3b8hyyr	4831	19	sigulticnatly	sigulticnatly	RB
cord-006860-a3b8hyyr	4831	20	increased	increase	VBN
cord-006860-a3b8hyyr	4831	21	(	(	-LRB-
cord-006860-a3b8hyyr	4831	22	p<0.0001	p<0.0001	NNP
cord-006860-a3b8hyyr	4831	23	)	)	-RRB-
cord-006860-a3b8hyyr	4831	24	compared	compare	VBN
cord-006860-a3b8hyyr	4831	25	to	to	IN
cord-006860-a3b8hyyr	4831	26	baseline	baseline	JJ
cord-006860-a3b8hyyr	4831	27	values	value	NNS
cord-006860-a3b8hyyr	4831	28	.	.	.
cord-006860-a3b8hyyr	4832	1	GP	GP	NNP
cord-006860-a3b8hyyr	4832	2	IIb	IIb	NNP
cord-006860-a3b8hyyr	4832	3	-	-	HYPH
cord-006860-a3b8hyyr	4832	4	IIla	IIla	NNP
cord-006860-a3b8hyyr	4832	5	,	,	,
cord-006860-a3b8hyyr	4832	6	GP	GP	NNP
cord-006860-a3b8hyyr	4832	7	Ib	Ib	NNP
cord-006860-a3b8hyyr	4832	8	,	,	,
cord-006860-a3b8hyyr	4832	9	P	P	NNP
cord-006860-a3b8hyyr	4832	10	-	-	HYPH
cord-006860-a3b8hyyr	4832	11	selectin	selectin	NNP
cord-006860-a3b8hyyr	4832	12	,	,	,
cord-006860-a3b8hyyr	4832	13	platelet	platelet	NN
cord-006860-a3b8hyyr	4832	14	count	count	NN
cord-006860-a3b8hyyr	4832	15	,	,	,
cord-006860-a3b8hyyr	4832	16	and	and	CC
cord-006860-a3b8hyyr	4833	1	FG	FG	NNP
cord-006860-a3b8hyyr	4833	2	were	be	VBD
cord-006860-a3b8hyyr	4833	3	significantly	significantly	RB
cord-006860-a3b8hyyr	4833	4	reduced	reduce	VBN
cord-006860-a3b8hyyr	4833	5	(	(	-LRB-
cord-006860-a3b8hyyr	4833	6	p<0.0001	p<0.0001	NNP
cord-006860-a3b8hyyr	4833	7	)	)	-RRB-
cord-006860-a3b8hyyr	4833	8	.	.	.
cord-006860-a3b8hyyr	4834	1	Analysis	analysis	NN
cord-006860-a3b8hyyr	4834	2	of	of	IN
cord-006860-a3b8hyyr	4834	3	variance	variance	NN
cord-006860-a3b8hyyr	4834	4	(	(	-LRB-
cord-006860-a3b8hyyr	4834	5	ANOVA	ANOVA	NNP
cord-006860-a3b8hyyr	4834	6	)	)	-RRB-
cord-006860-a3b8hyyr	4834	7	revealed	reveal	VBD
cord-006860-a3b8hyyr	4834	8	that	that	IN
cord-006860-a3b8hyyr	4834	9	postoperative	postoperative	JJ
cord-006860-a3b8hyyr	4834	10	values	value	NNS
cord-006860-a3b8hyyr	4834	11	of	of	IN
cord-006860-a3b8hyyr	4834	12	GP	GP	NNP
cord-006860-a3b8hyyr	4834	13	Ib	Ib	NNP
cord-006860-a3b8hyyr	4834	14	(	(	-LRB-
cord-006860-a3b8hyyr	4834	15	p<0.0001	p<0.0001	NNP
cord-006860-a3b8hyyr	4834	16	)	)	-RRB-
cord-006860-a3b8hyyr	4834	17	,	,	,
cord-006860-a3b8hyyr	4834	18	DD	DD	NNP
cord-006860-a3b8hyyr	4834	19	(	(	-LRB-
cord-006860-a3b8hyyr	4834	20	p	p	NN
cord-006860-a3b8hyyr	4834	21	<	<	XX
cord-006860-a3b8hyyr	4834	22	O.05	o.05	NN
cord-006860-a3b8hyyr	4834	23	)	)	-RRB-
cord-006860-a3b8hyyr	4834	24	,	,	,
cord-006860-a3b8hyyr	4834	25	FG	FG	NNP
cord-006860-a3b8hyyr	4834	26	(	(	-LRB-
cord-006860-a3b8hyyr	4834	27	p<0.01),and	p<0.01),and	CC
cord-006860-a3b8hyyr	4834	28	platelet	platelet	NN
cord-006860-a3b8hyyr	4834	29	count	count	NN
cord-006860-a3b8hyyr	4834	30	(	(	-LRB-
cord-006860-a3b8hyyr	4834	31	10<0.05	10<0.05	CD
cord-006860-a3b8hyyr	4834	32	)	)	-RRB-
cord-006860-a3b8hyyr	4834	33	had	have	VBD
cord-006860-a3b8hyyr	4834	34	a	a	DT
cord-006860-a3b8hyyr	4834	35	significant	significant	JJ
cord-006860-a3b8hyyr	4834	36	influence	influence	NN
cord-006860-a3b8hyyr	4834	37	on	on	IN
cord-006860-a3b8hyyr	4834	38	blood	blood	NN
cord-006860-a3b8hyyr	4834	39	loss	loss	NN
cord-006860-a3b8hyyr	4834	40	.	.	.
cord-006860-a3b8hyyr	4835	1	None	none	NN
cord-006860-a3b8hyyr	4835	2	of	of	IN
cord-006860-a3b8hyyr	4835	3	the	the	DT
cord-006860-a3b8hyyr	4835	4	preoperative	preoperative	JJ
cord-006860-a3b8hyyr	4835	5	data	datum	NNS
cord-006860-a3b8hyyr	4835	6	was	be	VBD
cord-006860-a3b8hyyr	4835	7	significantly	significantly	RB
cord-006860-a3b8hyyr	4835	8	associated	associate	VBN
cord-006860-a3b8hyyr	4835	9	with	with	IN
cord-006860-a3b8hyyr	4835	10	increased	increase	VBN
cord-006860-a3b8hyyr	4835	11	blood	blood	NN
cord-006860-a3b8hyyr	4835	12	loss	loss	NN
cord-006860-a3b8hyyr	4835	13	.	.	.
cord-006860-a3b8hyyr	4836	1	A	a	DT
cord-006860-a3b8hyyr	4836	2	subgroup	subgroup	NN
cord-006860-a3b8hyyr	4836	3	of	of	IN
cord-006860-a3b8hyyr	4836	4	patients	patient	NNS
cord-006860-a3b8hyyr	4836	5	who	who	WP
cord-006860-a3b8hyyr	4836	6	bled	bleed	VBD
cord-006860-a3b8hyyr	4836	7	more	more	JJR
cord-006860-a3b8hyyr	4836	8	than	than	IN
cord-006860-a3b8hyyr	4836	9	the	the	DT
cord-006860-a3b8hyyr	4836	10	mean	mean	NN
cord-006860-a3b8hyyr	4836	11	+	+	SYM
cord-006860-a3b8hyyr	4836	12	1	1	CD
cord-006860-a3b8hyyr	4836	13	SD	sd	NN
cord-006860-a3b8hyyr	4836	14	(	(	-LRB-
cord-006860-a3b8hyyr	4836	15	14	14	CD
cord-006860-a3b8hyyr	4836	16	cases	case	NNS
cord-006860-a3b8hyyr	4836	17	)	)	-RRB-
cord-006860-a3b8hyyr	4836	18	was	be	VBD
cord-006860-a3b8hyyr	4836	19	formed	form	VBN
cord-006860-a3b8hyyr	4836	20	_	_	NN
cord-006860-a3b8hyyr	4837	1	In	in	IN
cord-006860-a3b8hyyr	4837	2	logistic	logistic	JJ
cord-006860-a3b8hyyr	4837	3	regression	regression	NN
cord-006860-a3b8hyyr	4837	4	analysis	analysis	NN
cord-006860-a3b8hyyr	4837	5	GP	GP	NNP
cord-006860-a3b8hyyr	4837	6	Ib	Ib	NNP
cord-006860-a3b8hyyr	4837	7	expression	expression	NN
cord-006860-a3b8hyyr	4837	8	(	(	-LRB-
cord-006860-a3b8hyyr	4837	9	p=0.01	p=0.01	NNP
cord-006860-a3b8hyyr	4837	10	)	)	-RRB-
cord-006860-a3b8hyyr	4837	11	and	and	CC
cord-006860-a3b8hyyr	4837	12	DD	DD	NNP
cord-006860-a3b8hyyr	4837	13	(	(	-LRB-
cord-006860-a3b8hyyr	4837	14	p=0.007	p=0.007	NNP
cord-006860-a3b8hyyr	4837	15	)	)	-RRB-
cord-006860-a3b8hyyr	4837	16	were	be	VBD
cord-006860-a3b8hyyr	4837	17	of	of	IN
cord-006860-a3b8hyyr	4837	18	value	value	NN
cord-006860-a3b8hyyr	4837	19	in	in	IN
cord-006860-a3b8hyyr	4837	20	identifying	identify	VBG
cord-006860-a3b8hyyr	4837	21	bleeders	bleeder	NNS
cord-006860-a3b8hyyr	4837	22	.	.	.
cord-006860-a3b8hyyr	4838	1	The	the	DT
cord-006860-a3b8hyyr	4838	2	sensitivity	sensitivity	NN
cord-006860-a3b8hyyr	4838	3	of	of	IN
cord-006860-a3b8hyyr	4838	4	the	the	DT
cord-006860-a3b8hyyr	4838	5	equation	equation	NN
cord-006860-a3b8hyyr	4838	6	was	be	VBD
cord-006860-a3b8hyyr	4838	7	56	56	CD
cord-006860-a3b8hyyr	4838	8	%	%	NN
cord-006860-a3b8hyyr	4838	9	,	,	,
cord-006860-a3b8hyyr	4838	10	the	the	DT
cord-006860-a3b8hyyr	4838	11	stx	stx	NNP
cord-006860-a3b8hyyr	4838	12	~	~	NFP
cord-006860-a3b8hyyr	4838	13	ificity	ificity	NNP
cord-006860-a3b8hyyr	4838	14	97	97	CD
cord-006860-a3b8hyyr	4838	15	%	%	NN
cord-006860-a3b8hyyr	4838	16	and	and	CC
cord-006860-a3b8hyyr	4838	17	the	the	DT
cord-006860-a3b8hyyr	4838	18	positive	positive	JJ
cord-006860-a3b8hyyr	4838	19	predictive	predictive	JJ
cord-006860-a3b8hyyr	4838	20	value	value	NN
cord-006860-a3b8hyyr	4838	21	82	82	CD
cord-006860-a3b8hyyr	4838	22	%	%	NN
cord-006860-a3b8hyyr	4838	23	.	.	.
cord-006860-a3b8hyyr	4839	1	Although	although	IN
cord-006860-a3b8hyyr	4839	2	the	the	DT
cord-006860-a3b8hyyr	4839	3	reasons	reason	NNS
cord-006860-a3b8hyyr	4839	4	for	for	IN
cord-006860-a3b8hyyr	4839	5	an	an	DT
cord-006860-a3b8hyyr	4839	6	increased	increase	VBN
cord-006860-a3b8hyyr	4839	7	blood	blood	NN
cord-006860-a3b8hyyr	4839	8	loss	loss	NN
cord-006860-a3b8hyyr	4839	9	following	follow	VBG
cord-006860-a3b8hyyr	4839	10	ECC	ECC	NNP
cord-006860-a3b8hyyr	4839	11	are	be	VBP
cord-006860-a3b8hyyr	4839	12	multifactorial	multifactorial	JJ
cord-006860-a3b8hyyr	4839	13	,	,	,
cord-006860-a3b8hyyr	4839	14	we	-PRON-	PRP
cord-006860-a3b8hyyr	4839	15	were	be	VBD
cord-006860-a3b8hyyr	4839	16	able	able	JJ
cord-006860-a3b8hyyr	4839	17	to	to	TO
cord-006860-a3b8hyyr	4839	18	identify	identify	VB
cord-006860-a3b8hyyr	4839	19	a	a	DT
cord-006860-a3b8hyyr	4839	20	small	small	JJ
cord-006860-a3b8hyyr	4839	21	number	number	NN
cord-006860-a3b8hyyr	4839	22	parameters	parameter	NNS
cord-006860-a3b8hyyr	4839	23	with	with	IN
cord-006860-a3b8hyyr	4839	24	a	a	DT
cord-006860-a3b8hyyr	4839	25	significant	significant	JJ
cord-006860-a3b8hyyr	4839	26	infl	infl	NN
cord-006860-a3b8hyyr	4839	27	~	~	NFP
cord-006860-a3b8hyyr	4839	28	nco	nco	NNP
cord-006860-a3b8hyyr	4839	29	.	.	.
cord-006860-a3b8hyyr	4840	1	The	the	DT
cord-006860-a3b8hyyr	4840	2	combination	combination	NN
cord-006860-a3b8hyyr	4840	3	of	of	IN
cord-006860-a3b8hyyr	4840	4	the	the	DT
cord-006860-a3b8hyyr	4840	5	expression	expression	NN
cord-006860-a3b8hyyr	4840	6	of	of	IN
cord-006860-a3b8hyyr	4840	7	yon	yon	NNP
cord-006860-a3b8hyyr	4840	8	Willebrand	Willebrand	NNP
cord-006860-a3b8hyyr	4840	9	receptor	receptor	NN
cord-006860-a3b8hyyr	4840	10	on	on	IN
cord-006860-a3b8hyyr	4840	11	the	the	DT
cord-006860-a3b8hyyr	4840	12	platelet	platelet	NN
cord-006860-a3b8hyyr	4840	13	su_rfaco	su_rfaco	NNP
cord-006860-a3b8hyyr	4840	14	and	and	CC
cord-006860-a3b8hyyr	4840	15	D	d	NN
cord-006860-a3b8hyyr	4840	16	-	-	HYPH
cord-006860-a3b8hyyr	4840	17	dimer	dimer	JJ
cord-006860-a3b8hyyr	4840	18	levels	level	NNS
cord-006860-a3b8hyyr	4840	19	in	in	IN
cord-006860-a3b8hyyr	4840	20	plasma	plasma	NN
cord-006860-a3b8hyyr	4840	21	was	be	VBD
cord-006860-a3b8hyyr	4840	22	successful	successful	JJ
cord-006860-a3b8hyyr	4840	23	in	in	IN
cord-006860-a3b8hyyr	4840	24	predicling	predicle	VBG
cord-006860-a3b8hyyr	4840	25	an	an	DT
cord-006860-a3b8hyyr	4840	26	increased	increase	VBN
cord-006860-a3b8hyyr	4840	27	blood	blood	NN
cord-006860-a3b8hyyr	4840	28	loss	loss	NN
cord-006860-a3b8hyyr	4840	29	following	follow	VBG
cord-006860-a3b8hyyr	4840	30	heart	heart	NN
cord-006860-a3b8hyyr	4840	31	surgery	surgery	NN
cord-006860-a3b8hyyr	4840	32	.	.	.
cord-006860-a3b8hyyr	4841	1	This	this	DT
cord-006860-a3b8hyyr	4841	2	may	may	MD
cord-006860-a3b8hyyr	4841	3	be	be	VB
cord-006860-a3b8hyyr	4841	4	helpful	helpful	JJ
cord-006860-a3b8hyyr	4841	5	to	to	TO
cord-006860-a3b8hyyr	4841	6	define	define	VB
cord-006860-a3b8hyyr	4841	7	indications	indication	NNS
cord-006860-a3b8hyyr	4841	8	for	for	IN
cord-006860-a3b8hyyr	4841	9	platelet	platelet	NN
cord-006860-a3b8hyyr	4841	10	transfusion	transfusion	NN
cord-006860-a3b8hyyr	4841	11	and	and	CC
cord-006860-a3b8hyyr	4841	12	flesh	flesh	NN
cord-006860-a3b8hyyr	4841	13	frozen	frozen	JJ
cord-006860-a3b8hyyr	4841	14	plasma	plasma	NN
cord-006860-a3b8hyyr	4841	15	.	.	.
cord-006860-a3b8hyyr	4842	1	The	the	DT
cord-006860-a3b8hyyr	4842	2	most	most	RBS
cord-006860-a3b8hyyr	4842	3	widely	widely	RB
cord-006860-a3b8hyyr	4842	4	distributed	distribute	VBN
cord-006860-a3b8hyyr	4842	5	receptor	receptor	NN
cord-006860-a3b8hyyr	4842	6	for	for	IN
cord-006860-a3b8hyyr	4842	7	the	the	DT
cord-006860-a3b8hyyr	4842	8	Fc	Fc	NNP
cord-006860-a3b8hyyr	4842	9	-	-	HYPH
cord-006860-a3b8hyyr	4842	10	region	region	NN
cord-006860-a3b8hyyr	4842	11	of	of	IN
cord-006860-a3b8hyyr	4842	12	IgG	IgG	NNP
cord-006860-a3b8hyyr	4842	13	is	be	VBZ
cord-006860-a3b8hyyr	4842	14	the	the	DT
cord-006860-a3b8hyyr	4842	15	Fcreceptor	Fcreceptor	NNP
cord-006860-a3b8hyyr	4842	16	IIa	IIa	NNP
cord-006860-a3b8hyyr	4842	17	(	(	-LRB-
cord-006860-a3b8hyyr	4842	18	FcyRIIa	FcyRIIa	NNP
cord-006860-a3b8hyyr	4842	19	)	)	-RRB-
cord-006860-a3b8hyyr	4842	20	.	.	.
cord-006860-a3b8hyyr	4843	1	For	for	IN
cord-006860-a3b8hyyr	4843	2	this	this	DT
cord-006860-a3b8hyyr	4843	3	receptor	receptor	NN
cord-006860-a3b8hyyr	4843	4	a	a	DT
cord-006860-a3b8hyyr	4843	5	functionally	functionally	RB
cord-006860-a3b8hyyr	4843	6	relevant	relevant	JJ
cord-006860-a3b8hyyr	4843	7	polymorphism	polymorphism	NN
cord-006860-a3b8hyyr	4843	8	of	of	IN
cord-006860-a3b8hyyr	4843	9	amino	amino	NN
cord-006860-a3b8hyyr	4843	10	acids	acid	NNS
cord-006860-a3b8hyyr	4843	11	ArgmHis	ArgmHis	NNP
cord-006860-a3b8hyyr	4843	12	is	be	VBZ
cord-006860-a3b8hyyr	4843	13	known	know	VBN
cord-006860-a3b8hyyr	4843	14	.	.	.
cord-006860-a3b8hyyr	4844	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4844	2	previously	previously	RB
cord-006860-a3b8hyyr	4844	3	showed	show	VBD
cord-006860-a3b8hyyr	4844	4	HIT	hit	NN
cord-006860-a3b8hyyr	4844	5	-	-	HYPH
cord-006860-a3b8hyyr	4844	6	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4844	7	to	to	TO
cord-006860-a3b8hyyr	4844	8	bind	bind	VB
cord-006860-a3b8hyyr	4844	9	to	to	IN
cord-006860-a3b8hyyr	4844	10	platelets	platelet	NNS
cord-006860-a3b8hyyr	4844	11	via	via	IN
cord-006860-a3b8hyyr	4844	12	FeyRIIa	FeyRIIa	NNS
cord-006860-a3b8hyyr	4845	1	and	and	CC
cord-006860-a3b8hyyr	4845	2	now	now	RB
cord-006860-a3b8hyyr	4845	3	whether	whether	IN
cord-006860-a3b8hyyr	4845	4	clinical	clinical	JJ
cord-006860-a3b8hyyr	4845	5	manifestation	manifestation	NN
cord-006860-a3b8hyyr	4845	6	of	of	IN
cord-006860-a3b8hyyr	4845	7	HIT	HIT	NNP
cord-006860-a3b8hyyr	4845	8	is	be	VBZ
cord-006860-a3b8hyyr	4845	9	associated	associate	VBN
cord-006860-a3b8hyyr	4845	10	with	with	IN
cord-006860-a3b8hyyr	4845	11	the	the	DT
cord-006860-a3b8hyyr	4845	12	Fe'/RIIa	Fe'/RIIa	NNP
cord-006860-a3b8hyyr	4845	13	polymorphism	polymorphism	NN
cord-006860-a3b8hyyr	4845	14	.	.	.
cord-006860-a3b8hyyr	4846	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	4846	2	,	,	,
cord-006860-a3b8hyyr	4846	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	4846	4	developed	develop	VBD
cord-006860-a3b8hyyr	4846	5	a	a	DT
cord-006860-a3b8hyyr	4846	6	rapid	rapid	JJ
cord-006860-a3b8hyyr	4846	7	two	two	CD
cord-006860-a3b8hyyr	4846	8	step	step	NN
cord-006860-a3b8hyyr	4846	9	allelle	allelle	NN
cord-006860-a3b8hyyr	4846	10	-	-	HYPH
cord-006860-a3b8hyyr	4846	11	specific	specific	JJ
cord-006860-a3b8hyyr	4846	12	PCR	PCR	NNP
cord-006860-a3b8hyyr	4846	13	(	(	-LRB-
cord-006860-a3b8hyyr	4846	14	ASP	ASP	NNP
cord-006860-a3b8hyyr	4846	15	)	)	-RRB-
cord-006860-a3b8hyyr	4846	16	method	method	NN
cord-006860-a3b8hyyr	4846	17	for	for	IN
cord-006860-a3b8hyyr	4846	18	genotyping	genotype	VBG
cord-006860-a3b8hyyr	4846	19	the	the	DT
cord-006860-a3b8hyyr	4846	20	FoyRIIa	foyriia	NN
cord-006860-a3b8hyyr	4846	21	.	.	.
cord-006860-a3b8hyyr	4847	1	With	with	IN
cord-006860-a3b8hyyr	4847	2	control	control	NN
cord-006860-a3b8hyyr	4847	3	samples	sample	VBZ
cord-006860-a3b8hyyr	4847	4	the	the	DT
cord-006860-a3b8hyyr	4847	5	ASP	ASP	NNP
cord-006860-a3b8hyyr	4847	6	was	be	VBD
cord-006860-a3b8hyyr	4847	7	compared	compare	VBN
cord-006860-a3b8hyyr	4847	8	with	with	IN
cord-006860-a3b8hyyr	4847	9	the	the	DT
cord-006860-a3b8hyyr	4847	10	time	time	NN
cord-006860-a3b8hyyr	4847	11	consuming	consume	VBG
cord-006860-a3b8hyyr	4847	12	and	and	CC
cord-006860-a3b8hyyr	4847	13	complicated	complicated	JJ
cord-006860-a3b8hyyr	4847	14	allele	allele	NN
cord-006860-a3b8hyyr	4847	15	-	-	HYPH
cord-006860-a3b8hyyr	4847	16	specific	specific	JJ
cord-006860-a3b8hyyr	4847	17	oligonucleofide	oligonucleofide	JJ
cord-006860-a3b8hyyr	4847	18	hybridization	hybridization	NN
cord-006860-a3b8hyyr	4847	19	technique	technique	NN
cord-006860-a3b8hyyr	4847	20	,	,	,
cord-006860-a3b8hyyr	4847	21	the	the	DT
cord-006860-a3b8hyyr	4847	22	phenotype	phenotype	NN
cord-006860-a3b8hyyr	4847	23	expression	expression	NN
cord-006860-a3b8hyyr	4847	24	of	of	IN
cord-006860-a3b8hyyr	4847	25	FcTRIIa	FcTRIIa	NNP
cord-006860-a3b8hyyr	4847	26	(	(	-LRB-
cord-006860-a3b8hyyr	4847	27	using	use	VBG
cord-006860-a3b8hyyr	4847	28	the	the	DT
cord-006860-a3b8hyyr	4847	29	moabs	moab	NNS
cord-006860-a3b8hyyr	4847	30	IV.3	IV.3	NNP
cord-006860-a3b8hyyr	4847	31	and	and	CC
cord-006860-a3b8hyyr	4847	32	41H16	41h16	LS
cord-006860-a3b8hyyr	4847	33	)	)	-RRB-
cord-006860-a3b8hyyr	4847	34	and	and	CC
cord-006860-a3b8hyyr	4847	35	the	the	DT
cord-006860-a3b8hyyr	4847	36	monocyte	monocyte	NNP
cord-006860-a3b8hyyr	4847	37	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4847	38	assay	assay	NN
cord-006860-a3b8hyyr	4847	39	.	.	.
cord-006860-a3b8hyyr	4848	1	Complete	complete	JJ
cord-006860-a3b8hyyr	4848	2	concordance	concordance	NN
cord-006860-a3b8hyyr	4848	3	between	between	IN
cord-006860-a3b8hyyr	4848	4	the	the	DT
cord-006860-a3b8hyyr	4848	5	assays	assay	NNS
cord-006860-a3b8hyyr	4848	6	was	be	VBD
cord-006860-a3b8hyyr	4848	7	found	find	VBN
cord-006860-a3b8hyyr	4848	8	.	.	.
cord-006860-a3b8hyyr	4849	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4849	2	used	use	VBD
cord-006860-a3b8hyyr	4849	3	the	the	DT
cord-006860-a3b8hyyr	4849	4	ASP	ASP	NNP
cord-006860-a3b8hyyr	4849	5	to	to	TO
cord-006860-a3b8hyyr	4849	6	determine	determine	VB
cord-006860-a3b8hyyr	4849	7	the	the	DT
cord-006860-a3b8hyyr	4849	8	allelic	allelic	JJ
cord-006860-a3b8hyyr	4849	9	distribution	distribution	NN
cord-006860-a3b8hyyr	4849	10	of	of	IN
cord-006860-a3b8hyyr	4849	11	the	the	DT
cord-006860-a3b8hyyr	4849	12	Inst	Inst	NNP
cord-006860-a3b8hyyr	4849	13	.	.	.
cord-006860-a3b8hyyr	4850	1	Physiol	Physiol	NNP
cord-006860-a3b8hyyr	4850	2	.	.	.
cord-006860-a3b8hyyr	4851	1	Chem	Chem	NNP
cord-006860-a3b8hyyr	4851	2	.	.	.
cord-006860-a3b8hyyr	4852	1	,	,	,
cord-006860-a3b8hyyr	4852	2	Marburg	Marburg	NNP
cord-006860-a3b8hyyr	4852	3	;	;	:
cord-006860-a3b8hyyr	4852	4	*	*	NFP
cord-006860-a3b8hyyr	4852	5	)	)	-RRB-
cord-006860-a3b8hyyr	4852	6	Univ	Univ	NNP
cord-006860-a3b8hyyr	4852	7	.	.	NNP
cord-006860-a3b8hyyr	4852	8	of	of	IN
cord-006860-a3b8hyyr	4852	9	Virginia	Virginia	NNP
cord-006860-a3b8hyyr	4852	10	,	,	,
cord-006860-a3b8hyyr	4852	11	Charlottesville	Charlottesville	NNP
cord-006860-a3b8hyyr	4852	12	,	,	,
cord-006860-a3b8hyyr	4852	13	The	the	DT
cord-006860-a3b8hyyr	4852	14	functional	functional	JJ
cord-006860-a3b8hyyr	4852	15	heterogeneity	heterogeneity	NN
cord-006860-a3b8hyyr	4852	16	of	of	IN
cord-006860-a3b8hyyr	4852	17	blood	blood	NN
cord-006860-a3b8hyyr	4852	18	platelets	platelet	NNS
cord-006860-a3b8hyyr	4852	19	is	be	VBZ
cord-006860-a3b8hyyr	4852	20	clinically	clinically	RB
cord-006860-a3b8hyyr	4852	21	significant	significant	JJ
cord-006860-a3b8hyyr	4852	22	and	and	CC
cord-006860-a3b8hyyr	4852	23	may	may	MD
cord-006860-a3b8hyyr	4852	24	contribute	contribute	VB
cord-006860-a3b8hyyr	4852	25	to	to	IN
cord-006860-a3b8hyyr	4852	26	the	the	DT
cord-006860-a3b8hyyr	4852	27	pathogenesis	pathogenesis	NN
cord-006860-a3b8hyyr	4852	28	of	of	IN
cord-006860-a3b8hyyr	4852	29	cardiovascular	cardiovascular	JJ
cord-006860-a3b8hyyr	4852	30	and	and	CC
cord-006860-a3b8hyyr	4852	31	atherosclerotic	atherosclerotic	JJ
cord-006860-a3b8hyyr	4852	32	diseases	disease	NNS
cord-006860-a3b8hyyr	4852	33	l	l	NN
cord-006860-a3b8hyyr	4852	34	)	)	-RRB-
cord-006860-a3b8hyyr	4852	35	.	.	.
cord-006860-a3b8hyyr	4853	1	In	in	IN
cord-006860-a3b8hyyr	4853	2	order	order	NN
cord-006860-a3b8hyyr	4853	3	to	to	TO
cord-006860-a3b8hyyr	4853	4	understand	understand	VB
cord-006860-a3b8hyyr	4853	5	the	the	DT
cord-006860-a3b8hyyr	4853	6	biochemical	biochemical	JJ
cord-006860-a3b8hyyr	4853	7	basis	basis	NN
cord-006860-a3b8hyyr	4853	8	of	of	IN
cord-006860-a3b8hyyr	4853	9	the	the	DT
cord-006860-a3b8hyyr	4853	10	functional	functional	JJ
cord-006860-a3b8hyyr	4853	11	heterogeneity	heterogeneity	NN
cord-006860-a3b8hyyr	4853	12	of	of	IN
cord-006860-a3b8hyyr	4853	13	platelets	platelet	NNS
cord-006860-a3b8hyyr	4853	14	,	,	,
cord-006860-a3b8hyyr	4853	15	we	-PRON-	PRP
cord-006860-a3b8hyyr	4853	16	have	have	VBP
cord-006860-a3b8hyyr	4853	17	investigated	investigate	VBN
cord-006860-a3b8hyyr	4853	18	the	the	DT
cord-006860-a3b8hyyr	4853	19	signal	signal	NN
cord-006860-a3b8hyyr	4853	20	transducing	transducing	NN
cord-006860-a3b8hyyr	4853	21	pathway	pathway	NN
cord-006860-a3b8hyyr	4853	22	of	of	IN
cord-006860-a3b8hyyr	4853	23	platelet	platelet	NN
cord-006860-a3b8hyyr	4853	24	activation	activation	NN
cord-006860-a3b8hyyr	4853	25	a	a	DT
cord-006860-a3b8hyyr	4853	26	)	)	-RRB-
cord-006860-a3b8hyyr	4853	27	in	in	IN
cord-006860-a3b8hyyr	4853	28	terms	term	NNS
cord-006860-a3b8hyyr	4853	29	of	of	IN
cord-006860-a3b8hyyr	4853	30	guanylate	guanylate	NN
cord-006860-a3b8hyyr	4853	31	cyclase	cyclase	NN
cord-006860-a3b8hyyr	4853	32	and	and	CC
cord-006860-a3b8hyyr	4853	33	phosphodiesterase	phosphodiesterase	NN
cord-006860-a3b8hyyr	4853	34	activities	activity	NNS
cord-006860-a3b8hyyr	4853	35	and	and	CC
cord-006860-a3b8hyyr	4853	36	b	b	LS
cord-006860-a3b8hyyr	4853	37	)	)	-RRB-
cord-006860-a3b8hyyr	4853	38	at	at	IN
cord-006860-a3b8hyyr	4853	39	the	the	DT
cord-006860-a3b8hyyr	4853	40	level	level	NN
cord-006860-a3b8hyyr	4853	41	of	of	IN
cord-006860-a3b8hyyr	4853	42	protein	protein	NN
cord-006860-a3b8hyyr	4853	43	phosphorylation	phosphorylation	NN
cord-006860-a3b8hyyr	4853	44	and	and	CC
cord-006860-a3b8hyyr	4853	45	the	the	DT
cord-006860-a3b8hyyr	4853	46	receptor	receptor	NN
cord-006860-a3b8hyyr	4853	47	-	-	HYPH
cord-006860-a3b8hyyr	4853	48	effector	effector	NN
cord-006860-a3b8hyyr	4853	49	coupling	coupling	NN
cord-006860-a3b8hyyr	4853	50	via	via	IN
cord-006860-a3b8hyyr	4853	51	G	g	NN
cord-006860-a3b8hyyr	4853	52	i	i	NN
cord-006860-a3b8hyyr	4853	53	-	-	:
cord-006860-a3b8hyyr	4853	54	and	and	CC
cord-006860-a3b8hyyr	4853	55	Gs	Gs	NNP
cord-006860-a3b8hyyr	4853	56	-	-	HYPH
cord-006860-a3b8hyyr	4853	57	proteins	protein	NNS
cord-006860-a3b8hyyr	4853	58	in	in	IN
cord-006860-a3b8hyyr	4853	59	functional	functional	JJ
cord-006860-a3b8hyyr	4853	60	heterogeneous	heterogeneous	JJ
cord-006860-a3b8hyyr	4853	61	blood	blood	NN
cord-006860-a3b8hyyr	4853	62	platelet	platelet	NN
cord-006860-a3b8hyyr	4853	63	subpopulations	subpopulation	NNS
cord-006860-a3b8hyyr	4853	64	separated	separate	VBD
cord-006860-a3b8hyyr	4853	65	according	accord	VBG
cord-006860-a3b8hyyr	4853	66	to	to	IN
cord-006860-a3b8hyyr	4853	67	their	-PRON-	PRP$
cord-006860-a3b8hyyr	4853	68	densities	density	NNS
cord-006860-a3b8hyyr	4853	69	.	.	.
cord-006860-a3b8hyyr	4854	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	4854	2	,	,	,
cord-006860-a3b8hyyr	4854	3	we	-PRON-	PRP
cord-006860-a3b8hyyr	4854	4	analyzed	analyze	VBD
cord-006860-a3b8hyyr	4854	5	the	the	DT
cord-006860-a3b8hyyr	4854	6	ADP	ADP	NNP
cord-006860-a3b8hyyr	4854	7	-	-	HYPH
cord-006860-a3b8hyyr	4854	8	ribosylation	ribosylation	NN
cord-006860-a3b8hyyr	4854	9	of	of	IN
cord-006860-a3b8hyyr	4854	10	RhoA	RhoA	NNP
cord-006860-a3b8hyyr	4854	11	,	,	,
cord-006860-a3b8hyyr	4854	12	which	which	WDT
cord-006860-a3b8hyyr	4854	13	is	be	VBZ
cord-006860-a3b8hyyr	4854	14	a	a	DT
cord-006860-a3b8hyyr	4854	15	lowmolecular	lowmolecular	JJ
cord-006860-a3b8hyyr	4854	16	weight	weight	NN
cord-006860-a3b8hyyr	4854	17	GTP	gtp	NN
cord-006860-a3b8hyyr	4854	18	-	-	HYPH
cord-006860-a3b8hyyr	4854	19	binding	bind	VBG
cord-006860-a3b8hyyr	4854	20	protein	protein	NN
cord-006860-a3b8hyyr	4854	21	and	and	CC
cord-006860-a3b8hyyr	4854	22	is	be	VBZ
cord-006860-a3b8hyyr	4854	23	thought	think	VBN
cord-006860-a3b8hyyr	4854	24	to	to	TO
cord-006860-a3b8hyyr	4854	25	be	be	VB
cord-006860-a3b8hyyr	4854	26	involved	involve	VBN
cord-006860-a3b8hyyr	4854	27	in	in	IN
cord-006860-a3b8hyyr	4854	28	the	the	DT
cord-006860-a3b8hyyr	4854	29	platelet	platelet	NN
cord-006860-a3b8hyyr	4854	30	"	"	``
cord-006860-a3b8hyyr	4854	31	shape	shape	NN
cord-006860-a3b8hyyr	4854	32	change	change	NN
cord-006860-a3b8hyyr	4854	33	"	"	''
cord-006860-a3b8hyyr	4854	34	reaction	reaction	NN
cord-006860-a3b8hyyr	4854	35	and	and	CC
cord-006860-a3b8hyyr	4854	36	aggregation	aggregation	NN
cord-006860-a3b8hyyr	4854	37	.	.	.
cord-006860-a3b8hyyr	4855	1	Aggregation	aggregation	NN
cord-006860-a3b8hyyr	4855	2	was	be	VBD
cord-006860-a3b8hyyr	4855	3	enhanced	enhance	VBN
cord-006860-a3b8hyyr	4855	4	in	in	IN
cord-006860-a3b8hyyr	4855	5	low	low	JJ
cord-006860-a3b8hyyr	4855	6	-	-	HYPH
cord-006860-a3b8hyyr	4855	7	density	density	NN
cord-006860-a3b8hyyr	4855	8	platelets	platelet	NNS
cord-006860-a3b8hyyr	4855	9	(	(	-LRB-
cord-006860-a3b8hyyr	4855	10	SP	SP	NNP
cord-006860-a3b8hyyr	4855	11	I	I	NNP
cord-006860-a3b8hyyr	4855	12	)	)	-RRB-
cord-006860-a3b8hyyr	4855	13	and	and	CC
cord-006860-a3b8hyyr	4855	14	less	less	RBR
cord-006860-a3b8hyyr	4855	15	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	4855	16	when	when	WRB
cord-006860-a3b8hyyr	4855	17	cGMP	cGMP	NNP
cord-006860-a3b8hyyr	4855	18	was	be	VBD
cord-006860-a3b8hyyr	4855	19	increased	increase	VBN
cord-006860-a3b8hyyr	4855	20	by	by	IN
cord-006860-a3b8hyyr	4855	21	NO	NO	NNP
cord-006860-a3b8hyyr	4855	22	,	,	,
cord-006860-a3b8hyyr	4855	23	compared	compare	VBN
cord-006860-a3b8hyyr	4855	24	to	to	IN
cord-006860-a3b8hyyr	4855	25	high	high	JJ
cord-006860-a3b8hyyr	4855	26	-	-	HYPH
cord-006860-a3b8hyyr	4855	27	density	density	NN
cord-006860-a3b8hyyr	4855	28	platelets	platelet	NNS
cord-006860-a3b8hyyr	4855	29	(	(	-LRB-
cord-006860-a3b8hyyr	4855	30	SPIII	SPIII	NNP
cord-006860-a3b8hyyr	4855	31	)	)	-RRB-
cord-006860-a3b8hyyr	4855	32	.	.	.
cord-006860-a3b8hyyr	4856	1	SP	SP	NNP
cord-006860-a3b8hyyr	4856	2	I	-PRON-	PRP
cord-006860-a3b8hyyr	4856	3	possessed	possess	VBD
cord-006860-a3b8hyyr	4856	4	a	a	DT
cord-006860-a3b8hyyr	4856	5	lower	low	JJR
cord-006860-a3b8hyyr	4856	6	basal	basal	NN
cord-006860-a3b8hyyr	4856	7	level	level	NN
cord-006860-a3b8hyyr	4856	8	of	of	IN
cord-006860-a3b8hyyr	4856	9	cGMP	cGMP	NNP
cord-006860-a3b8hyyr	4856	10	and	and	CC
cord-006860-a3b8hyyr	4856	11	exhibited	exhibit	VBD
cord-006860-a3b8hyyr	4856	12	a	a	DT
cord-006860-a3b8hyyr	4856	13	smaller	small	JJR
cord-006860-a3b8hyyr	4856	14	increase	increase	NN
cord-006860-a3b8hyyr	4856	15	in	in	IN
cord-006860-a3b8hyyr	4856	16	cGMP	cGMP	NNP
cord-006860-a3b8hyyr	4856	17	after	after	IN
cord-006860-a3b8hyyr	4856	18	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4856	19	with	with	IN
cord-006860-a3b8hyyr	4856	20	NO	no	NN
cord-006860-a3b8hyyr	4856	21	.	.	.
cord-006860-a3b8hyyr	4857	1	Cyclic	Cyclic	NNP
cord-006860-a3b8hyyr	4857	2	AMP	amp	NN
cord-006860-a3b8hyyr	4857	3	-	-	HYPH
cord-006860-a3b8hyyr	4857	4	dependent	dependent	JJ
cord-006860-a3b8hyyr	4857	5	phosphodiesterase	phosphodiesterase	NN
cord-006860-a3b8hyyr	4857	6	activity	activity	NN
cord-006860-a3b8hyyr	4857	7	was	be	VBD
cord-006860-a3b8hyyr	4857	8	higher	high	JJR
cord-006860-a3b8hyyr	4857	9	in	in	IN
cord-006860-a3b8hyyr	4857	10	SP	SP	NNP
cord-006860-a3b8hyyr	4858	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	4858	2	compared	compare	VBD
cord-006860-a3b8hyyr	4858	3	to	to	IN
cord-006860-a3b8hyyr	4858	4	SPIII	SPIII	NNP
cord-006860-a3b8hyyr	4858	5	,	,	,
cord-006860-a3b8hyyr	4858	6	whereas	whereas	IN
cord-006860-a3b8hyyr	4858	7	cGMP	cgmp	JJ
cord-006860-a3b8hyyr	4858	8	-	-	HYPH
cord-006860-a3b8hyyr	4858	9	dependent	dependent	JJ
cord-006860-a3b8hyyr	4858	10	phosphodiesterase	phosphodiesterase	NN
cord-006860-a3b8hyyr	4858	11	activity	activity	NN
cord-006860-a3b8hyyr	4858	12	was	be	VBD
cord-006860-a3b8hyyr	4858	13	similar	similar	JJ
cord-006860-a3b8hyyr	4858	14	in	in	IN
cord-006860-a3b8hyyr	4858	15	SP	SP	NNP
cord-006860-a3b8hyyr	4858	16	I	I	NNP
cord-006860-a3b8hyyr	4858	17	and	and	CC
cord-006860-a3b8hyyr	4858	18	SP	SP	NNP
cord-006860-a3b8hyyr	4858	19	III	III	NNP
cord-006860-a3b8hyyr	4858	20	.	.	.
cord-006860-a3b8hyyr	4859	1	SP	SP	NNP
cord-006860-a3b8hyyr	4859	2	I	I	NNP
cord-006860-a3b8hyyr	4859	3	,	,	,
cord-006860-a3b8hyyr	4859	4	when	when	WRB
cord-006860-a3b8hyyr	4859	5	compared	compare	VBN
cord-006860-a3b8hyyr	4859	6	to	to	IN
cord-006860-a3b8hyyr	4859	7	SP	SP	NNP
cord-006860-a3b8hyyr	4859	8	III	III	NNP
cord-006860-a3b8hyyr	4859	9	platelets	platelet	NNS
cord-006860-a3b8hyyr	4859	10	,	,	,
cord-006860-a3b8hyyr	4859	11	showed	show	VBD
cord-006860-a3b8hyyr	4859	12	a	a	DT
cord-006860-a3b8hyyr	4859	13	higher	high	JJR
cord-006860-a3b8hyyr	4859	14	degree	degree	NN
cord-006860-a3b8hyyr	4859	15	of	of	IN
cord-006860-a3b8hyyr	4859	16	prephosphorylation	prephosphorylation	NN
cord-006860-a3b8hyyr	4859	17	of	of	IN
cord-006860-a3b8hyyr	4859	18	proteins	protein	NNS
cord-006860-a3b8hyyr	4859	19	in	in	IN
cord-006860-a3b8hyyr	4859	20	the	the	DT
cord-006860-a3b8hyyr	4859	21	range	range	NN
cord-006860-a3b8hyyr	4859	22	of	of	IN
cord-006860-a3b8hyyr	4859	23	47	47	CD
cord-006860-a3b8hyyr	4859	24	,	,	,
cord-006860-a3b8hyyr	4859	25	32	32	CD
cord-006860-a3b8hyyr	4859	26	-	-	SYM
cord-006860-a3b8hyyr	4859	27	34	34	CD
cord-006860-a3b8hyyr	4859	28	,	,	,
cord-006860-a3b8hyyr	4859	29	and	and	CC
cord-006860-a3b8hyyr	4859	30	20	20	CD
cord-006860-a3b8hyyr	4859	31	-	-	SYM
cord-006860-a3b8hyyr	4859	32	22	22	CD
cord-006860-a3b8hyyr	4859	33	kDa	kDa	NNS
cord-006860-a3b8hyyr	4859	34	.	.	.
cord-006860-a3b8hyyr	4860	1	After	after	IN
cord-006860-a3b8hyyr	4860	2	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	4860	3	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4860	4	,	,	,
cord-006860-a3b8hyyr	4860	5	the	the	DT
cord-006860-a3b8hyyr	4860	6	phosphorylation	phosphorylation	NN
cord-006860-a3b8hyyr	4860	7	of	of	IN
cord-006860-a3b8hyyr	4860	8	these	these	DT
cord-006860-a3b8hyyr	4860	9	proteins	protein	NNS
cord-006860-a3b8hyyr	4860	10	was	be	VBD
cord-006860-a3b8hyyr	4860	11	similar	similar	JJ
cord-006860-a3b8hyyr	4860	12	in	in	IN
cord-006860-a3b8hyyr	4860	13	the	the	DT
cord-006860-a3b8hyyr	4860	14	subpopulations	subpopulation	NNS
cord-006860-a3b8hyyr	4860	15	.	.	.
cord-006860-a3b8hyyr	4861	1	Pertussis	pertussis	NN
cord-006860-a3b8hyyr	4861	2	toxin	toxin	NN
cord-006860-a3b8hyyr	4861	3	,	,	,
cord-006860-a3b8hyyr	4861	4	induced	induce	VBN
cord-006860-a3b8hyyr	4861	5	ADP	adp	NN
cord-006860-a3b8hyyr	4861	6	-	-	HYPH
cord-006860-a3b8hyyr	4861	7	ribosylation	ribosylation	NN
cord-006860-a3b8hyyr	4861	8	of	of	IN
cord-006860-a3b8hyyr	4861	9	the	the	DT
cord-006860-a3b8hyyr	4861	10	40	40	CD
cord-006860-a3b8hyyr	4861	11	-	-	SYM
cord-006860-a3b8hyyr	4861	12	41	41	CD
cord-006860-a3b8hyyr	4861	13	kDa	kDa	NNP
cord-006860-a3b8hyyr	4861	14	Gi	Gi	NNP
cord-006860-a3b8hyyr	4861	15	-	-	HYPH
cord-006860-a3b8hyyr	4861	16	protein	protein	NN
cord-006860-a3b8hyyr	4861	17	was	be	VBD
cord-006860-a3b8hyyr	4861	18	highest	high	JJS
cord-006860-a3b8hyyr	4861	19	in	in	IN
cord-006860-a3b8hyyr	4861	20	SP	SP	NNP
cord-006860-a3b8hyyr	4861	21	I	I	NNP
cord-006860-a3b8hyyr	4861	22	,	,	,
cord-006860-a3b8hyyr	4861	23	whereas	whereas	IN
cord-006860-a3b8hyyr	4861	24	Cholera	cholera	NN
cord-006860-a3b8hyyr	4861	25	toxin	toxin	NN
cord-006860-a3b8hyyr	4861	26	induced	induce	VBN
cord-006860-a3b8hyyr	4861	27	ADPribosylation	adpribosylation	NN
cord-006860-a3b8hyyr	4861	28	of	of	IN
cord-006860-a3b8hyyr	4861	29	the	the	DT
cord-006860-a3b8hyyr	4861	30	Gs	Gs	NNP
cord-006860-a3b8hyyr	4861	31	-	-	HYPH
cord-006860-a3b8hyyr	4861	32	protein	protein	NN
cord-006860-a3b8hyyr	4861	33	and	and	CC
cord-006860-a3b8hyyr	4861	34	botulinum	botulinum	NN
cord-006860-a3b8hyyr	4862	1	C3	C3	NNP
cord-006860-a3b8hyyr	4863	1	exoenzyme	exoenzyme	NNPS
cord-006860-a3b8hyyr	4863	2	-	-	HYPH
cord-006860-a3b8hyyr	4863	3	induced	induce	VBN
cord-006860-a3b8hyyr	4863	4	ADPfibosylation	adpfibosylation	NN
cord-006860-a3b8hyyr	4863	5	of	of	IN
cord-006860-a3b8hyyr	4863	6	RhoA	RhoA	NNP
cord-006860-a3b8hyyr	4863	7	were	be	VBD
cord-006860-a3b8hyyr	4863	8	highest	high	JJS
cord-006860-a3b8hyyr	4863	9	in	in	IN
cord-006860-a3b8hyyr	4863	10	SP	SP	NNP
cord-006860-a3b8hyyr	4863	11	III	III	NNP
cord-006860-a3b8hyyr	4863	12	.	.	.
cord-006860-a3b8hyyr	4864	1	The	the	DT
cord-006860-a3b8hyyr	4864	2	findings	finding	NNS
cord-006860-a3b8hyyr	4864	3	suggest	suggest	VBP
cord-006860-a3b8hyyr	4864	4	that	that	IN
cord-006860-a3b8hyyr	4864	5	a	a	LS
cord-006860-a3b8hyyr	4864	6	)	)	-RRB-
cord-006860-a3b8hyyr	4864	7	the	the	DT
cord-006860-a3b8hyyr	4864	8	higher	high	JJR
cord-006860-a3b8hyyr	4864	9	aggregability	aggregability	NN
cord-006860-a3b8hyyr	4864	10	in	in	IN
cord-006860-a3b8hyyr	4864	11	SP	SP	NNP
cord-006860-a3b8hyyr	4865	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	4865	2	compared	compare	VBD
cord-006860-a3b8hyyr	4865	3	to	to	IN
cord-006860-a3b8hyyr	4865	4	SP	SP	NNP
cord-006860-a3b8hyyr	4865	5	III	III	NNP
cord-006860-a3b8hyyr	4865	6	may	may	MD
cord-006860-a3b8hyyr	4865	7	be	be	VB
cord-006860-a3b8hyyr	4865	8	caused	cause	VBN
cord-006860-a3b8hyyr	4865	9	by	by	IN
cord-006860-a3b8hyyr	4865	10	a	a	DT
cord-006860-a3b8hyyr	4865	11	poorer	poor	JJR
cord-006860-a3b8hyyr	4865	12	ability	ability	NN
cord-006860-a3b8hyyr	4865	13	of	of	IN
cord-006860-a3b8hyyr	4865	14	guanylate	guanylate	NN
cord-006860-a3b8hyyr	4865	15	cyclase	cyclase	NN
cord-006860-a3b8hyyr	4865	16	to	to	TO
cord-006860-a3b8hyyr	4865	17	form	form	VB
cord-006860-a3b8hyyr	4865	18	cGMP	cGMP	NNP
cord-006860-a3b8hyyr	4865	19	and	and	CC
cord-006860-a3b8hyyr	4865	20	a	a	DT
cord-006860-a3b8hyyr	4865	21	higher	high	JJR
cord-006860-a3b8hyyr	4865	22	activitiy	activitiy	NN
cord-006860-a3b8hyyr	4865	23	of	of	IN
cord-006860-a3b8hyyr	4865	24	cAMPdependent	cAMPdependent	NNP
cord-006860-a3b8hyyr	4865	25	phosphodiesterase	phosphodiesterase	NN
cord-006860-a3b8hyyr	4865	26	and	and	CC
cord-006860-a3b8hyyr	4865	27	that	that	DT
cord-006860-a3b8hyyr	4865	28	b	b	NN
cord-006860-a3b8hyyr	4865	29	)	)	-RRB-
cord-006860-a3b8hyyr	4865	30	the	the	DT
cord-006860-a3b8hyyr	4865	31	ADP	ADP	NNP
cord-006860-a3b8hyyr	4865	32	-	-	HYPH
cord-006860-a3b8hyyr	4865	33	ribosylation	ribosylation	NN
cord-006860-a3b8hyyr	4865	34	of	of	IN
cord-006860-a3b8hyyr	4865	35	G	g	NN
cord-006860-a3b8hyyr	4865	36	-	-	HYPH
cord-006860-a3b8hyyr	4865	37	protein	protein	NN
cord-006860-a3b8hyyr	4865	38	subunits	subunit	NNS
cord-006860-a3b8hyyr	4865	39	and	and	CC
cord-006860-a3b8hyyr	4865	40	RheA	RheA	NNS
cord-006860-a3b8hyyr	4865	41	may	may	MD
cord-006860-a3b8hyyr	4865	42	contribute	contribute	VB
cord-006860-a3b8hyyr	4865	43	to	to	IN
cord-006860-a3b8hyyr	4865	44	the	the	DT
cord-006860-a3b8hyyr	4865	45	functional	functional	JJ
cord-006860-a3b8hyyr	4865	46	heterogeneity	heterogeneity	NN
cord-006860-a3b8hyyr	4865	47	in	in	IN
cord-006860-a3b8hyyr	4865	48	the	the	DT
cord-006860-a3b8hyyr	4865	49	subpopulation	subpopulation	NN
cord-006860-a3b8hyyr	4865	50	leading	lead	VBG
cord-006860-a3b8hyyr	4865	51	to	to	IN
cord-006860-a3b8hyyr	4865	52	the	the	DT
cord-006860-a3b8hyyr	4865	53	greater	great	JJR
cord-006860-a3b8hyyr	4865	54	ability	ability	NN
cord-006860-a3b8hyyr	4865	55	of	of	IN
cord-006860-a3b8hyyr	4865	56	SP	SP	NNP
cord-006860-a3b8hyyr	4865	57	I	-PRON-	PRP
cord-006860-a3b8hyyr	4865	58	for	for	IN
cord-006860-a3b8hyyr	4865	59	aggregation	aggregation	NN
cord-006860-a3b8hyyr	4865	60	.	.	.
cord-006860-a3b8hyyr	4866	1	1	1	LS
cord-006860-a3b8hyyr	4866	2	)	)	-RRB-
cord-006860-a3b8hyyr	4867	1	Opper	Opper	NNP
cord-006860-a3b8hyyr	4867	2	et	et	NNP
cord-006860-a3b8hyyr	4867	3	al	al	NNP
cord-006860-a3b8hyyr	4867	4	.	.	.
cord-006860-a3b8hyyr	4868	1	,	,	,
cord-006860-a3b8hyyr	4868	2	Atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	4868	3	,	,	,
cord-006860-a3b8hyyr	4868	4	113	113	CD
cord-006860-a3b8hyyr	4868	5	,	,	,
cord-006860-a3b8hyyr	4868	6	211	211	CD
cord-006860-a3b8hyyr	4868	7	-	-	SYM
cord-006860-a3b8hyyr	4868	8	217	217	CD
cord-006860-a3b8hyyr	4868	9	,	,	,
cord-006860-a3b8hyyr	4868	10	1995	1995	CD
cord-006860-a3b8hyyr	4868	11	.	.	.
cord-006860-a3b8hyyr	4869	1	Causes	cause	NNS
cord-006860-a3b8hyyr	4869	2	of	of	IN
cord-006860-a3b8hyyr	4869	3	accelerated	accelerate	VBN
cord-006860-a3b8hyyr	4869	4	atherogenesis	atherogenesis	NN
cord-006860-a3b8hyyr	4869	5	in	in	IN
cord-006860-a3b8hyyr	4869	6	non	non	JJ
cord-006860-a3b8hyyr	4869	7	-	-	JJ
cord-006860-a3b8hyyr	4869	8	insulin	insulin	JJ
cord-006860-a3b8hyyr	4869	9	-	-	HYPH
cord-006860-a3b8hyyr	4869	10	dependent	dependent	JJ
cord-006860-a3b8hyyr	4869	11	diabetes	diabetes	NN
cord-006860-a3b8hyyr	4869	12	mellitus	mellitus	NN
cord-006860-a3b8hyyr	4869	13	(	(	-LRB-
cord-006860-a3b8hyyr	4869	14	NIDDM	NIDDM	NNP
cord-006860-a3b8hyyr	4869	15	)	)	-RRB-
cord-006860-a3b8hyyr	4869	16	,	,	,
cord-006860-a3b8hyyr	4869	17	known	know	VBN
cord-006860-a3b8hyyr	4869	18	to	to	TO
cord-006860-a3b8hyyr	4869	19	be	be	VB
cord-006860-a3b8hyyr	4869	20	associated	associate	VBN
cord-006860-a3b8hyyr	4869	21	with	with	IN
cord-006860-a3b8hyyr	4869	22	increased	increase	VBN
cord-006860-a3b8hyyr	4869	23	plasma	plasma	NN
cord-006860-a3b8hyyr	4869	24	activity	activity	NN
cord-006860-a3b8hyyr	4869	25	of	of	IN
cord-006860-a3b8hyyr	4869	26	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4869	27	activator	activator	NN
cord-006860-a3b8hyyr	4869	28	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4869	29	type	type	NN
cord-006860-a3b8hyyr	4869	30	1	1	CD
cord-006860-a3b8hyyr	4869	31	(	(	-LRB-
cord-006860-a3b8hyyr	4869	32	PAl	PAl	NNP
cord-006860-a3b8hyyr	4869	33	-	-	HYPH
cord-006860-a3b8hyyr	4869	34	l	l	NN
cord-006860-a3b8hyyr	4869	35	)	)	-RRB-
cord-006860-a3b8hyyr	4869	36	as	as	RB
cord-006860-a3b8hyyr	4869	37	well	well	RB
cord-006860-a3b8hyyr	4869	38	as	as	IN
cord-006860-a3b8hyyr	4869	39	with	with	IN
cord-006860-a3b8hyyr	4869	40	increased	increase	VBN
cord-006860-a3b8hyyr	4869	41	plasma	plasma	NN
cord-006860-a3b8hyyr	4869	42	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4869	43	of	of	IN
cord-006860-a3b8hyyr	4869	44	proinsulin	proinsulin	NN
cord-006860-a3b8hyyr	4869	45	and	and	CC
cord-006860-a3b8hyyr	4869	46	insulin	insulin	NN
cord-006860-a3b8hyyr	4869	47	,	,	,
cord-006860-a3b8hyyr	4869	48	remain	remain	VBP
cord-006860-a3b8hyyr	4869	49	enigmatic	enigmatic	JJ
cord-006860-a3b8hyyr	4869	50	.	.	.
cord-006860-a3b8hyyr	4870	1	This	this	DT
cord-006860-a3b8hyyr	4870	2	study	study	NN
cord-006860-a3b8hyyr	4870	3	was	be	VBD
cord-006860-a3b8hyyr	4870	4	designed	design	VBN
cord-006860-a3b8hyyr	4870	5	to	to	TO
cord-006860-a3b8hyyr	4870	6	determine	determine	VB
cord-006860-a3b8hyyr	4870	7	whether	whether	IN
cord-006860-a3b8hyyr	4870	8	proinsulin	proinsulin	NN
cord-006860-a3b8hyyr	4870	9	and	and	CC
cord-006860-a3b8hyyr	4870	10	insulin	insulin	NN
cord-006860-a3b8hyyr	4870	11	increase	increase	NN
cord-006860-a3b8hyyr	4870	12	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	4870	13	in	in	IN
cord-006860-a3b8hyyr	4870	14	vivo	vivo	NN
cord-006860-a3b8hyyr	4870	15	thereby	thereby	RB
cord-006860-a3b8hyyr	4870	16	potentially	potentially	RB
cord-006860-a3b8hyyr	4870	17	accelerating	accelerate	VBG
cord-006860-a3b8hyyr	4870	18	atherogenesis	atherogenesis	NN
cord-006860-a3b8hyyr	4870	19	.	.	.
cord-006860-a3b8hyyr	4871	1	To	to	TO
cord-006860-a3b8hyyr	4871	2	simulate	simulate	VB
cord-006860-a3b8hyyr	4871	3	hyper(pro)insulinemia	hyper(pro)insulinemia	NNP
cord-006860-a3b8hyyr	4871	4	seen	see	VBN
cord-006860-a3b8hyyr	4871	5	with	with	IN
cord-006860-a3b8hyyr	4871	6	NIDDM	NIDDM	NNP
cord-006860-a3b8hyyr	4871	7	,	,	,
cord-006860-a3b8hyyr	4871	8	we	-PRON-	PRP
cord-006860-a3b8hyyr	4871	9	infused	infuse	VBD
cord-006860-a3b8hyyr	4871	10	equimolar	equimolar	JJ
cord-006860-a3b8hyyr	4871	11	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4871	12	of	of	IN
cord-006860-a3b8hyyr	4871	13	insulin	insulin	NN
cord-006860-a3b8hyyr	4871	14	(	(	-LRB-
cord-006860-a3b8hyyr	4871	15	1	1	CD
cord-006860-a3b8hyyr	4871	16	IU	IU	NNP
cord-006860-a3b8hyyr	4871	17	/	/	SYM
cord-006860-a3b8hyyr	4871	18	kg	kg	NNP
cord-006860-a3b8hyyr	4871	19	)	)	-RRB-
cord-006860-a3b8hyyr	4871	20	,	,	,
cord-006860-a3b8hyyr	4871	21	proinsulin	proinsulin	NNP
cord-006860-a3b8hyyr	4871	22	,	,	,
cord-006860-a3b8hyyr	4871	23	C	c	NN
cord-006860-a3b8hyyr	4871	24	-	-	HYPH
cord-006860-a3b8hyyr	4871	25	peptide	peptide	NN
cord-006860-a3b8hyyr	4871	26	,	,	,
cord-006860-a3b8hyyr	4871	27	or	or	CC
cord-006860-a3b8hyyr	4871	28	placebo	placebo	NN
cord-006860-a3b8hyyr	4871	29	,	,	,
cord-006860-a3b8hyyr	4871	30	all	all	DT
cord-006860-a3b8hyyr	4871	31	endotoxin	endotoxin	NN
cord-006860-a3b8hyyr	4871	32	-	-	HYPH
cord-006860-a3b8hyyr	4871	33	free	free	JJ
cord-006860-a3b8hyyr	4871	34	,	,	,
cord-006860-a3b8hyyr	4871	35	i.v	i.v	NNP
cord-006860-a3b8hyyr	4871	36	.	.	.
cord-006860-a3b8hyyr	4872	1	over	over	IN
cord-006860-a3b8hyyr	4872	2	1	1	CD
cord-006860-a3b8hyyr	4872	3	h	h	NN
cord-006860-a3b8hyyr	4872	4	in	in	IN
cord-006860-a3b8hyyr	4872	5	53	53	CD
cord-006860-a3b8hyyr	4872	6	conscious	conscious	JJ
cord-006860-a3b8hyyr	4872	7	rabbits	rabbit	NNS
cord-006860-a3b8hyyr	4872	8	maintained	maintain	VBD
cord-006860-a3b8hyyr	4872	9	euglycemic	euglycemic	JJ
cord-006860-a3b8hyyr	4872	10	.	.	.
cord-006860-a3b8hyyr	4873	1	Plasma	Plasma	NNP
cord-006860-a3b8hyyr	4873	2	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	4873	3	did	do	VBD
cord-006860-a3b8hyyr	4873	4	not	not	RB
cord-006860-a3b8hyyr	4873	5	increase	increase	VB
cord-006860-a3b8hyyr	4873	6	with	with	IN
cord-006860-a3b8hyyr	4873	7	placebo	placebo	NN
cord-006860-a3b8hyyr	4873	8	(	(	-LRB-
cord-006860-a3b8hyyr	4873	9	n=16	n=16	NNP
cord-006860-a3b8hyyr	4873	10	)	)	-RRB-
cord-006860-a3b8hyyr	4873	11	or	or	CC
cord-006860-a3b8hyyr	4873	12	C	c	NN
cord-006860-a3b8hyyr	4873	13	-	-	HYPH
cord-006860-a3b8hyyr	4873	14	peptide	peptide	NN
cord-006860-a3b8hyyr	4873	15	(	(	-LRB-
cord-006860-a3b8hyyr	4873	16	n=4	n=4	NNS
cord-006860-a3b8hyyr	4873	17	)	)	-RRB-
cord-006860-a3b8hyyr	4873	18	,	,	,
cord-006860-a3b8hyyr	4873	19	but	but	CC
cord-006860-a3b8hyyr	4873	20	did	do	VBD
cord-006860-a3b8hyyr	4873	21	with	with	IN
cord-006860-a3b8hyyr	4873	22	proinsulin	proinsulin	NNP
cord-006860-a3b8hyyr	4873	23	and	and	CC
cord-006860-a3b8hyyr	4873	24	insulin	insulin	NN
cord-006860-a3b8hyyr	4873	25	peaking	peak	VBG
cord-006860-a3b8hyyr	4873	26	in	in	IN
cord-006860-a3b8hyyr	4873	27	3	3	CD
cord-006860-a3b8hyyr	4873	28	h	h	NN
cord-006860-a3b8hyyr	4873	29	at	at	IN
cord-006860-a3b8hyyr	4873	30	3.5-and	3.5-and	CD
cord-006860-a3b8hyyr	4873	31	3.7-fold	3.7-fold	CD
cord-006860-a3b8hyyr	4874	1	(	(	-LRB-
cord-006860-a3b8hyyr	4874	2	n=16	n=16	NNP
cord-006860-a3b8hyyr	4874	3	and	and	CC
cord-006860-a3b8hyyr	4874	4	n=17	n=17	NNP
cord-006860-a3b8hyyr	4874	5	,	,	,
cord-006860-a3b8hyyr	4874	6	p<0.O02	p<0.O02	NNP
cord-006860-a3b8hyyr	4874	7	for	for	IN
cord-006860-a3b8hyyr	4874	8	each	each	DT
cord-006860-a3b8hyyr	4874	9	)	)	-RRB-
cord-006860-a3b8hyyr	4874	10	in	in	IN
cord-006860-a3b8hyyr	4874	11	parallel	parallel	NN
cord-006860-a3b8hyyr	4874	12	with	with	IN
cord-006860-a3b8hyyr	4874	13	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	4874	14	protein	protein	NN
cord-006860-a3b8hyyr	4874	15	quantified	quantify	VBN
cord-006860-a3b8hyyr	4874	16	by	by	IN
cord-006860-a3b8hyyr	4874	17	reverse	reverse	JJ
cord-006860-a3b8hyyr	4874	18	fibrin	fibrin	NN
cord-006860-a3b8hyyr	4874	19	autography	autography	NN
cord-006860-a3b8hyyr	4874	20	.	.	.
cord-006860-a3b8hyyr	4875	1	The	the	DT
cord-006860-a3b8hyyr	4875	2	increases	increase	NNS
cord-006860-a3b8hyyr	4875	3	were	be	VBD
cord-006860-a3b8hyyr	4875	4	specific	specific	JJ
cord-006860-a3b8hyyr	4875	5	as	as	IN
cord-006860-a3b8hyyr	4875	6	reflected	reflect	VBN
cord-006860-a3b8hyyr	4875	7	by	by	IN
cord-006860-a3b8hyyr	4875	8	unchanged	unchanged	JJ
cord-006860-a3b8hyyr	4875	9	activities	activity	NNS
cord-006860-a3b8hyyr	4875	10	of	of	IN
cord-006860-a3b8hyyr	4875	11	o~-antiplasmin	o~-antiplasmin	NN
cord-006860-a3b8hyyr	4875	12	and	and	CC
cord-006860-a3b8hyyr	4875	13	t	t	NNP
cord-006860-a3b8hyyr	4875	14	-	-	HYPH
cord-006860-a3b8hyyr	4875	15	PA	PA	NNP
cord-006860-a3b8hyyr	4875	16	.	.	.
cord-006860-a3b8hyyr	4876	1	PAt-1	pat-1	NN
cord-006860-a3b8hyyr	4876	2	gene	gene	NN
cord-006860-a3b8hyyr	4876	3	expression	expression	NN
cord-006860-a3b8hyyr	4876	4	(	(	-LRB-
cord-006860-a3b8hyyr	4876	5	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	4876	6	mRNA	mRNA	NNP
cord-006860-a3b8hyyr	4876	7	)	)	-RRB-
cord-006860-a3b8hyyr	4876	8	increased	increase	VBD
cord-006860-a3b8hyyr	4876	9	with	with	IN
cord-006860-a3b8hyyr	4876	10	proinsulin	proinsulin	NNP
cord-006860-a3b8hyyr	4876	11	and	and	CC
cord-006860-a3b8hyyr	4876	12	insulin	insulin	NN
cord-006860-a3b8hyyr	4876	13	by	by	IN
cord-006860-a3b8hyyr	4876	14	2.1-and	2.1-and	CD
cord-006860-a3b8hyyr	4876	15	2.1-fold	2.1-fold	CD
cord-006860-a3b8hyyr	4876	16	in	in	IN
cord-006860-a3b8hyyr	4876	17	3	3	CD
cord-006860-a3b8hyyr	4876	18	h	h	NN
cord-006860-a3b8hyyr	4876	19	in	in	IN
cord-006860-a3b8hyyr	4876	20	aorta	aorta	NN
cord-006860-a3b8hyyr	4876	21	,	,	,
cord-006860-a3b8hyyr	4876	22	1.9-and	1.9-and	CD
cord-006860-a3b8hyyr	4876	23	2.4-fold	2.4-fold	CD
cord-006860-a3b8hyyr	4876	24	in	in	IN
cord-006860-a3b8hyyr	4876	25	liver	liver	NN
cord-006860-a3b8hyyr	4876	26	(	(	-LRB-
cord-006860-a3b8hyyr	4876	27	p<0.05	p<0.05	NN
cord-006860-a3b8hyyr	4876	28	for	for	IN
cord-006860-a3b8hyyr	4876	29	each	each	DT
cord-006860-a3b8hyyr	4876	30	)	)	-RRB-
cord-006860-a3b8hyyr	4876	31	,	,	,
cord-006860-a3b8hyyr	4876	32	but	but	CC
cord-006860-a3b8hyyr	4876	33	not	not	RB
cord-006860-a3b8hyyr	4876	34	in	in	IN
cord-006860-a3b8hyyr	4876	35	heart	heart	NN
cord-006860-a3b8hyyr	4876	36	,	,	,
cord-006860-a3b8hyyr	4876	37	lung	lung	NN
cord-006860-a3b8hyyr	4876	38	,	,	,
cord-006860-a3b8hyyr	4876	39	spleen	spleen	NNS
cord-006860-a3b8hyyr	4876	40	,	,	,
cord-006860-a3b8hyyr	4876	41	or	or	CC
cord-006860-a3b8hyyr	4876	42	kidney	kidney	NN
cord-006860-a3b8hyyr	4876	43	and	and	CC
cord-006860-a3b8hyyr	4876	44	returned	return	VBD
cord-006860-a3b8hyyr	4876	45	to	to	IN
cord-006860-a3b8hyyr	4876	46	baseline	baseline	NN
cord-006860-a3b8hyyr	4876	47	in	in	IN
cord-006860-a3b8hyyr	4876	48	24	24	CD
cord-006860-a3b8hyyr	4876	49	h	h	NNP
cord-006860-a3b8hyyr	4876	50	(	(	-LRB-
cord-006860-a3b8hyyr	4876	51	n=4	n=4	PDT
cord-006860-a3b8hyyr	4876	52	each	each	DT
cord-006860-a3b8hyyr	4876	53	)	)	-RRB-
cord-006860-a3b8hyyr	4876	54	.	.	.
cord-006860-a3b8hyyr	4877	1	In	in	IN
cord-006860-a3b8hyyr	4877	2	situ	situ	NN
cord-006860-a3b8hyyr	4877	3	hybridization	hybridization	NN
cord-006860-a3b8hyyr	4877	4	localized	localize	VBD
cord-006860-a3b8hyyr	4877	5	the	the	DT
cord-006860-a3b8hyyr	4877	6	increased	increase	VBN
cord-006860-a3b8hyyr	4877	7	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	4878	1	mRNA	mrna	NN
cord-006860-a3b8hyyr	4878	2	in	in	IN
cord-006860-a3b8hyyr	4878	3	aorta	aorta	NN
cord-006860-a3b8hyyr	4878	4	to	to	IN
cord-006860-a3b8hyyr	4878	5	endothelium	endothelium	NN
cord-006860-a3b8hyyr	4878	6	(	(	-LRB-
cord-006860-a3b8hyyr	4878	7	n=3	n=3	NN
cord-006860-a3b8hyyr	4878	8	each	each	DT
cord-006860-a3b8hyyr	4878	9	)	)	-RRB-
cord-006860-a3b8hyyr	4878	10	.	.	.
cord-006860-a3b8hyyr	4879	1	Thus	thus	RB
cord-006860-a3b8hyyr	4879	2	,	,	,
cord-006860-a3b8hyyr	4879	3	both	both	CC
cord-006860-a3b8hyyr	4879	4	proinsulin	proinsulin	NN
cord-006860-a3b8hyyr	4879	5	and	and	CC
cord-006860-a3b8hyyr	4879	6	insulin	insulin	NN
cord-006860-a3b8hyyr	4879	7	directly	directly	RB
cord-006860-a3b8hyyr	4879	8	augment	augment	VB
cord-006860-a3b8hyyr	4879	9	gene	gene	NN
cord-006860-a3b8hyyr	4879	10	expression	expression	NN
cord-006860-a3b8hyyr	4879	11	of	of	IN
cord-006860-a3b8hyyr	4879	12	PAl-1	PAl-1	NNP
cord-006860-a3b8hyyr	4879	13	in	in	IN
cord-006860-a3b8hyyr	4879	14	arterial	arterial	JJ
cord-006860-a3b8hyyr	4879	15	endothelium	endothelium	NN
cord-006860-a3b8hyyr	4879	16	in	in	IN
cord-006860-a3b8hyyr	4879	17	vivo	vivo	NN
cord-006860-a3b8hyyr	4879	18	,	,	,
cord-006860-a3b8hyyr	4879	19	thereby	thereby	RB
cord-006860-a3b8hyyr	4879	20	increasing	increase	VBG
cord-006860-a3b8hyyr	4879	21	plasma	plasma	NN
cord-006860-a3b8hyyr	4879	22	PAl-1	pal-1	NN
cord-006860-a3b8hyyr	4879	23	activity	activity	NN
cord-006860-a3b8hyyr	4879	24	,	,	,
cord-006860-a3b8hyyr	4879	25	attenuating	attenuate	VBG
cord-006860-a3b8hyyr	4879	26	endogenous	endogenous	JJ
cord-006860-a3b8hyyr	4879	27	fibrinolysis	fibrinolysis	NN
cord-006860-a3b8hyyr	4879	28	,	,	,
cord-006860-a3b8hyyr	4879	29	and	and	CC
cord-006860-a3b8hyyr	4879	30	potentially	potentially	RB
cord-006860-a3b8hyyr	4879	31	accelerating	accelerate	VBG
cord-006860-a3b8hyyr	4879	32	atherogenesis	atherogenesis	NN
cord-006860-a3b8hyyr	4879	33	.	.	.
cord-006860-a3b8hyyr	4880	1	The	the	DT
cord-006860-a3b8hyyr	4880	2	sarco	sarco	JJ
cord-006860-a3b8hyyr	4880	3	-	-	HYPH
cord-006860-a3b8hyyr	4880	4	endoplasmic	endoplasmic	NN
cord-006860-a3b8hyyr	4880	5	-	-	HYPH
cord-006860-a3b8hyyr	4880	6	retikulum	retikulum	NN
cord-006860-a3b8hyyr	4880	7	Ca+÷ATPases	Ca+÷ATPases	NNP
cord-006860-a3b8hyyr	4880	8	(	(	-LRB-
cord-006860-a3b8hyyr	4880	9	SERCA	SERCA	NNP
cord-006860-a3b8hyyr	4880	10	)	)	-RRB-
cord-006860-a3b8hyyr	4880	11	that	that	WDT
cord-006860-a3b8hyyr	4880	12	sequester	sequester	VBP
cord-006860-a3b8hyyr	4880	13	calcium	calcium	NN
cord-006860-a3b8hyyr	4880	14	into	into	IN
cord-006860-a3b8hyyr	4880	15	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	4880	16	stores	store	NNS
cord-006860-a3b8hyyr	4880	17	,	,	,
cord-006860-a3b8hyyr	4880	18	represent	represent	VBP
cord-006860-a3b8hyyr	4880	19	the	the	DT
cord-006860-a3b8hyyr	4880	20	most	most	RBS
cord-006860-a3b8hyyr	4880	21	important	important	JJ
cord-006860-a3b8hyyr	4880	22	mechanism	mechanism	NN
cord-006860-a3b8hyyr	4880	23	to	to	TO
cord-006860-a3b8hyyr	4880	24	maintain	maintain	VB
cord-006860-a3b8hyyr	4880	25	cytosolic	cytosolic	JJ
cord-006860-a3b8hyyr	4880	26	calcium	calcium	NN
cord-006860-a3b8hyyr	4880	27	levels	level	NNS
cord-006860-a3b8hyyr	4880	28	low	low	JJ
cord-006860-a3b8hyyr	4880	29	and	and	CC
cord-006860-a3b8hyyr	4880	30	to	to	TO
cord-006860-a3b8hyyr	4880	31	return	return	VB
cord-006860-a3b8hyyr	4880	32	to	to	IN
cord-006860-a3b8hyyr	4880	33	a	a	DT
cord-006860-a3b8hyyr	4880	34	resting	rest	VBG
cord-006860-a3b8hyyr	4880	35	level	level	NN
cord-006860-a3b8hyyr	4880	36	after	after	IN
cord-006860-a3b8hyyr	4880	37	activation	activation	NN
cord-006860-a3b8hyyr	4880	38	.	.	.
cord-006860-a3b8hyyr	4881	1	Recent	recent	JJ
cord-006860-a3b8hyyr	4881	2	studies	study	NNS
cord-006860-a3b8hyyr	4881	3	in	in	IN
cord-006860-a3b8hyyr	4881	4	platelets	platelet	NNS
cord-006860-a3b8hyyr	4881	5	and	and	CC
cord-006860-a3b8hyyr	4881	6	rat	rat	NN
cord-006860-a3b8hyyr	4881	7	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4881	8	cells	cell	NNS
cord-006860-a3b8hyyr	4881	9	have	have	VBP
cord-006860-a3b8hyyr	4881	10	identified	identify	VBN
cord-006860-a3b8hyyr	4881	11	two	two	CD
cord-006860-a3b8hyyr	4881	12	forms	form	NNS
cord-006860-a3b8hyyr	4881	13	belonging	belong	VBG
cord-006860-a3b8hyyr	4881	14	to	to	IN
cord-006860-a3b8hyyr	4881	15	the	the	DT
cord-006860-a3b8hyyr	4881	16	SERCA	SERCA	NNP
cord-006860-a3b8hyyr	4881	17	2b	2b	NN
cord-006860-a3b8hyyr	4881	18	and	and	CC
cord-006860-a3b8hyyr	4881	19	SERCA	SERCA	NNP
cord-006860-a3b8hyyr	4881	20	3	3	CD
cord-006860-a3b8hyyr	4881	21	types	type	NNS
cord-006860-a3b8hyyr	4881	22	.	.	.
cord-006860-a3b8hyyr	4882	1	The	the	DT
cord-006860-a3b8hyyr	4882	2	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	4882	3	antibody	antibody	NN
cord-006860-a3b8hyyr	4882	4	PL	pl	NN
cord-006860-a3b8hyyr	4882	5	/	/	SYM
cord-006860-a3b8hyyr	4882	6	IM	IM	NNP
cord-006860-a3b8hyyr	4882	7	430	430	CD
cord-006860-a3b8hyyr	4882	8	raised	raise	VBD
cord-006860-a3b8hyyr	4882	9	to	to	IN
cord-006860-a3b8hyyr	4882	10	human	human	JJ
cord-006860-a3b8hyyr	4882	11	platelet	platelet	NN
cord-006860-a3b8hyyr	4882	12	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	4882	13	membranes	membrane	NNS
cord-006860-a3b8hyyr	4882	14	has	have	VBZ
cord-006860-a3b8hyyr	4882	15	been	be	VBN
cord-006860-a3b8hyyr	4882	16	shown	show	VBN
cord-006860-a3b8hyyr	4882	17	to	to	TO
cord-006860-a3b8hyyr	4882	18	recognise	recognise	VB
cord-006860-a3b8hyyr	4882	19	the	the	DT
cord-006860-a3b8hyyr	4882	20	SERCA	SERCA	NNP
cord-006860-a3b8hyyr	4882	21	3	3	CD
cord-006860-a3b8hyyr	4882	22	÷+	÷+	NNP
cord-006860-a3b8hyyr	4882	23	isoform	isoform	NN
cord-006860-a3b8hyyr	4882	24	and	and	CC
cord-006860-a3b8hyyr	4882	25	to	to	TO
cord-006860-a3b8hyyr	4882	26	inhibit	inhibit	VB
cord-006860-a3b8hyyr	4882	27	Ca	Ca	NNP
cord-006860-a3b8hyyr	4882	28	sequestration	sequestration	NN
cord-006860-a3b8hyyr	4882	29	in	in	IN
cord-006860-a3b8hyyr	4882	30	human	human	JJ
cord-006860-a3b8hyyr	4882	31	platelets	platelet	NNS
cord-006860-a3b8hyyr	4882	32	.	.	.
cord-006860-a3b8hyyr	4883	1	The	the	DT
cord-006860-a3b8hyyr	4883	2	aim	aim	NN
cord-006860-a3b8hyyr	4883	3	of	of	IN
cord-006860-a3b8hyyr	4883	4	this	this	DT
cord-006860-a3b8hyyr	4883	5	study	study	NN
cord-006860-a3b8hyyr	4883	6	was	be	VBD
cord-006860-a3b8hyyr	4883	7	to	to	TO
cord-006860-a3b8hyyr	4883	8	identify	identify	VB
cord-006860-a3b8hyyr	4883	9	Ca	Ca	NNP
cord-006860-a3b8hyyr	4883	10	ATPase	ATPase	NNP
cord-006860-a3b8hyyr	4883	11	distribution	distribution	NN
cord-006860-a3b8hyyr	4883	12	in	in	IN
cord-006860-a3b8hyyr	4883	13	human	human	JJ
cord-006860-a3b8hyyr	4883	14	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	4883	15	vein	vein	NN
cord-006860-a3b8hyyr	4883	16	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4883	17	cells	cell	NNS
cord-006860-a3b8hyyr	4883	18	(	(	-LRB-
cord-006860-a3b8hyyr	4883	19	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	4883	20	)	)	-RRB-
cord-006860-a3b8hyyr	4883	21	and	and	CC
cord-006860-a3b8hyyr	4883	22	human	human	JJ
cord-006860-a3b8hyyr	4883	23	polymorphonuclear	polymorphonuclear	NN
cord-006860-a3b8hyyr	4883	24	leukocytes	leukocyte	NNS
cord-006860-a3b8hyyr	4883	25	(	(	-LRB-
cord-006860-a3b8hyyr	4883	26	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	4883	27	)	)	-RRB-
cord-006860-a3b8hyyr	4883	28	.	.	.
cord-006860-a3b8hyyr	4884	1	Polyclonal	Polyclonal	NNP
cord-006860-a3b8hyyr	4884	2	antibodies	antibody	NNS
cord-006860-a3b8hyyr	4884	3	with	with	IN
cord-006860-a3b8hyyr	4884	4	known	know	VBN
cord-006860-a3b8hyyr	4884	5	specificity	specificity	NN
cord-006860-a3b8hyyr	4884	6	towards	towards	IN
cord-006860-a3b8hyyr	4884	7	SERCA	SERCA	NNP
cord-006860-a3b8hyyr	4884	8	2b	2b	NNP
cord-006860-a3b8hyyr	4884	9	(	(	-LRB-
cord-006860-a3b8hyyr	4884	10	R	R	NNP
cord-006860-a3b8hyyr	4884	11	2/88	2/88	CD
cord-006860-a3b8hyyr	4884	12	)	)	-RRB-
cord-006860-a3b8hyyr	4884	13	and	and	CC
cord-006860-a3b8hyyr	4884	14	SERCA	SERCA	NNP
cord-006860-a3b8hyyr	4884	15	3	3	CD
cord-006860-a3b8hyyr	4884	16	(	(	-LRB-
cord-006860-a3b8hyyr	4884	17	89/3	89/3	NNP
cord-006860-a3b8hyyr	4884	18	)	)	-RRB-
cord-006860-a3b8hyyr	4884	19	in	in	IN
cord-006860-a3b8hyyr	4884	20	addition	addition	NN
cord-006860-a3b8hyyr	4884	21	to	to	IN
cord-006860-a3b8hyyr	4884	22	PL	PL	NNP
cord-006860-a3b8hyyr	4884	23	/	/	SYM
cord-006860-a3b8hyyr	4884	24	IM	IM	NNP
cord-006860-a3b8hyyr	4884	25	430	430	CD
cord-006860-a3b8hyyr	4884	26	were	be	VBD
cord-006860-a3b8hyyr	4884	27	used	use	VBN
cord-006860-a3b8hyyr	4884	28	in	in	IN
cord-006860-a3b8hyyr	4884	29	histochemical	histochemical	JJ
cord-006860-a3b8hyyr	4884	30	studies	study	NNS
cord-006860-a3b8hyyr	4884	31	of	of	IN
cord-006860-a3b8hyyr	4884	32	permeabilised	permeabilised	JJ
cord-006860-a3b8hyyr	4884	33	cells	cell	NNS
cord-006860-a3b8hyyr	4884	34	and	and	CC
cord-006860-a3b8hyyr	4884	35	in	in	IN
cord-006860-a3b8hyyr	4884	36	Western	western	JJ
cord-006860-a3b8hyyr	4884	37	blotting	blotting	NN
cord-006860-a3b8hyyr	4884	38	experiments	experiment	NNS
cord-006860-a3b8hyyr	4884	39	using	use	VBG
cord-006860-a3b8hyyr	4884	40	cell	cell	NN
cord-006860-a3b8hyyr	4884	41	lysates	lysate	NNS
cord-006860-a3b8hyyr	4884	42	and	and	CC
cord-006860-a3b8hyyr	4884	43	mixed	mixed	JJ
cord-006860-a3b8hyyr	4884	44	membranes	membrane	NNS
cord-006860-a3b8hyyr	4884	45	.	.	.
cord-006860-a3b8hyyr	4885	1	Using	use	VBG
cord-006860-a3b8hyyr	4885	2	the	the	DT
cord-006860-a3b8hyyr	4885	3	alkaline	alkaline	JJ
cord-006860-a3b8hyyr	4885	4	phosphatase	phosphatase	NN
cord-006860-a3b8hyyr	4885	5	anti	anti	JJ
cord-006860-a3b8hyyr	4885	6	-	-	JJ
cord-006860-a3b8hyyr	4885	7	alkaline	alkaline	JJ
cord-006860-a3b8hyyr	4885	8	phosphatase	phosphatase	NN
cord-006860-a3b8hyyr	4885	9	(	(	-LRB-
cord-006860-a3b8hyyr	4885	10	APAAP	APAAP	NNP
cord-006860-a3b8hyyr	4885	11	)	)	-RRB-
cord-006860-a3b8hyyr	4885	12	method	method	NN
cord-006860-a3b8hyyr	4885	13	R	R	NNP
cord-006860-a3b8hyyr	4885	14	2/88	2/88	CD
cord-006860-a3b8hyyr	4885	15	and	and	CC
cord-006860-a3b8hyyr	4885	16	89/3	89/3	NNP
cord-006860-a3b8hyyr	4885	17	reacted	react	VBD
cord-006860-a3b8hyyr	4885	18	strongly	strongly	RB
cord-006860-a3b8hyyr	4885	19	with	with	IN
cord-006860-a3b8hyyr	4885	20	proteins	protein	NNS
cord-006860-a3b8hyyr	4885	21	in	in	IN
cord-006860-a3b8hyyr	4885	22	permeabilised	permeabilise	VBN
cord-006860-a3b8hyyr	4885	23	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	4885	24	and	and	CC
cord-006860-a3b8hyyr	4885	25	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	4885	26	,	,	,
cord-006860-a3b8hyyr	4885	27	however	however	RB
cord-006860-a3b8hyyr	4885	28	PL	PL	NNP
cord-006860-a3b8hyyr	4885	29	/	/	SYM
cord-006860-a3b8hyyr	4885	30	IM	IM	NNP
cord-006860-a3b8hyyr	4885	31	430	430	CD
cord-006860-a3b8hyyr	4885	32	showed	show	VBD
cord-006860-a3b8hyyr	4885	33	good	good	JJ
cord-006860-a3b8hyyr	4885	34	staining	staining	NN
cord-006860-a3b8hyyr	4885	35	only	only	RB
cord-006860-a3b8hyyr	4885	36	with	with	IN
cord-006860-a3b8hyyr	4885	37	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	4885	38	.	.	.
cord-006860-a3b8hyyr	4886	1	In	in	IN
cord-006860-a3b8hyyr	4886	2	Western	western	JJ
cord-006860-a3b8hyyr	4886	3	blotting	blotting	NN
cord-006860-a3b8hyyr	4886	4	experiments	experiment	NNS
cord-006860-a3b8hyyr	4886	5	R	R	NNP
cord-006860-a3b8hyyr	4886	6	2/88	2/88	CD
cord-006860-a3b8hyyr	4886	7	recognised	recognise	VBN
cord-006860-a3b8hyyr	4886	8	proteins	protein	NNS
cord-006860-a3b8hyyr	4886	9	with	with	IN
cord-006860-a3b8hyyr	4886	10	molecular	molecular	JJ
cord-006860-a3b8hyyr	4886	11	sizes	size	NNS
cord-006860-a3b8hyyr	4886	12	of	of	IN
cord-006860-a3b8hyyr	4886	13	100	100	CD
cord-006860-a3b8hyyr	4886	14	kDa	kDa	NNS
cord-006860-a3b8hyyr	4886	15	(	(	-LRB-
cord-006860-a3b8hyyr	4886	16	known	know	VBN
cord-006860-a3b8hyyr	4886	17	to	to	TO
cord-006860-a3b8hyyr	4886	18	be	be	VB
cord-006860-a3b8hyyr	4886	19	the	the	DT
cord-006860-a3b8hyyr	4886	20	parent	parent	NN
cord-006860-a3b8hyyr	4886	21	Ca++ATPase	Ca++ATPase	NNP
cord-006860-a3b8hyyr	4886	22	)	)	-RRB-
cord-006860-a3b8hyyr	4886	23	and	and	CC
cord-006860-a3b8hyyr	4886	24	70	70	CD
cord-006860-a3b8hyyr	4886	25	kDa	kDa	NNS
cord-006860-a3b8hyyr	4886	26	(	(	-LRB-
cord-006860-a3b8hyyr	4886	27	which	which	WDT
cord-006860-a3b8hyyr	4886	28	may	may	MD
cord-006860-a3b8hyyr	4886	29	represent	represent	VB
cord-006860-a3b8hyyr	4886	30	antibody	antibody	NN
cord-006860-a3b8hyyr	4886	31	recognised	recognise	VBN
cord-006860-a3b8hyyr	4886	32	degradation	degradation	NN
cord-006860-a3b8hyyr	4886	33	product	product	NN
cord-006860-a3b8hyyr	4886	34	)	)	-RRB-
cord-006860-a3b8hyyr	4886	35	,	,	,
cord-006860-a3b8hyyr	4886	36	in	in	IN
cord-006860-a3b8hyyr	4886	37	both	both	CC
cord-006860-a3b8hyyr	4886	38	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	4886	39	and	and	CC
cord-006860-a3b8hyyr	4886	40	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	4886	41	.	.	.
cord-006860-a3b8hyyr	4887	1	89/3	89/3	NNP
cord-006860-a3b8hyyr	4887	2	÷+	÷+	NNPS
cord-006860-a3b8hyyr	4887	3	recognised	recognise	VBN
cord-006860-a3b8hyyr	4887	4	bands	band	NNS
cord-006860-a3b8hyyr	4887	5	at	at	IN
cord-006860-a3b8hyyr	4887	6	100	100	CD
cord-006860-a3b8hyyr	4887	7	kDa	kDa	NNS
cord-006860-a3b8hyyr	4887	8	(	(	-LRB-
cord-006860-a3b8hyyr	4887	9	parent	parent	NN
cord-006860-a3b8hyyr	4887	10	Ca	Ca	NNP
cord-006860-a3b8hyyr	4887	11	ATPase	ATPase	NNP
cord-006860-a3b8hyyr	4887	12	)	)	-RRB-
cord-006860-a3b8hyyr	4887	13	,	,	,
cord-006860-a3b8hyyr	4887	14	74	74	CD
cord-006860-a3b8hyyr	4887	15	kDa	kDa	NNS
cord-006860-a3b8hyyr	4887	16	and	and	CC
cord-006860-a3b8hyyr	4887	17	46	46	CD
cord-006860-a3b8hyyr	4887	18	kDa	kDa	NNS
cord-006860-a3b8hyyr	4887	19	in	in	IN
cord-006860-a3b8hyyr	4887	20	both	both	CC
cord-006860-a3b8hyyr	4887	21	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	4887	22	and	and	CC
cord-006860-a3b8hyyr	4887	23	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	4887	24	membranes	membrane	NNS
cord-006860-a3b8hyyr	4887	25	.	.	.
cord-006860-a3b8hyyr	4888	1	In	in	IN
cord-006860-a3b8hyyr	4888	2	agreement	agreement	NN
cord-006860-a3b8hyyr	4888	3	with	with	IN
cord-006860-a3b8hyyr	4888	4	histochemical	histochemical	JJ
cord-006860-a3b8hyyr	4888	5	results	result	NNS
cord-006860-a3b8hyyr	4888	6	PL	PL	NNP
cord-006860-a3b8hyyr	4888	7	/	/	SYM
cord-006860-a3b8hyyr	4888	8	IM	IM	NNP
cord-006860-a3b8hyyr	4888	9	430	430	CD
cord-006860-a3b8hyyr	4888	10	recognised	recognise	VBN
cord-006860-a3b8hyyr	4888	11	proteins	protein	NNS
cord-006860-a3b8hyyr	4888	12	(	(	-LRB-
cord-006860-a3b8hyyr	4888	13	100	100	CD
cord-006860-a3b8hyyr	4888	14	,	,	,
cord-006860-a3b8hyyr	4888	15	74	74	CD
cord-006860-a3b8hyyr	4888	16	and	and	CC
cord-006860-a3b8hyyr	4888	17	46	46	CD
cord-006860-a3b8hyyr	4888	18	45	45	CD
cord-006860-a3b8hyyr	4888	19	+	+	SYM
cord-006860-a3b8hyyr	4888	20	+	+	CC
cord-006860-a3b8hyyr	4888	21	kDa	kDa	NNS
cord-006860-a3b8hyyr	4888	22	)	)	-RRB-
cord-006860-a3b8hyyr	4888	23	only	only	RB
cord-006860-a3b8hyyr	4888	24	in	in	IN
cord-006860-a3b8hyyr	4888	25	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	4888	26	membranes	membrane	NNS
cord-006860-a3b8hyyr	4888	27	.	.	.
cord-006860-a3b8hyyr	4889	1	In	in	IN
cord-006860-a3b8hyyr	4889	2	Ca	Ca	NNP
cord-006860-a3b8hyyr	4889	3	transport	transport	NN
cord-006860-a3b8hyyr	4889	4	studies	study	NNS
cord-006860-a3b8hyyr	4889	5	PL	pl	NN
cord-006860-a3b8hyyr	4889	6	/	/	SYM
cord-006860-a3b8hyyr	4889	7	IM	IM	NNP
cord-006860-a3b8hyyr	4889	8	430	430	CD
cord-006860-a3b8hyyr	4889	9	÷+	÷+	NFP
cord-006860-a3b8hyyr	4889	10	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	4889	11	Ca	Ca	NNP
cord-006860-a3b8hyyr	4889	12	uptake	uptake	NN
cord-006860-a3b8hyyr	4889	13	in	in	IN
cord-006860-a3b8hyyr	4889	14	membranes	membrane	NNS
cord-006860-a3b8hyyr	4889	15	prepared	prepare	VBN
cord-006860-a3b8hyyr	4889	16	from	from	IN
cord-006860-a3b8hyyr	4889	17	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	4889	18	but	but	CC
cord-006860-a3b8hyyr	4889	19	not	not	RB
cord-006860-a3b8hyyr	4889	20	in	in	IN
cord-006860-a3b8hyyr	4889	21	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	4889	22	.	.	.
cord-006860-a3b8hyyr	4890	1	The	the	DT
cord-006860-a3b8hyyr	4890	2	distinct	distinct	JJ
cord-006860-a3b8hyyr	4890	3	reaction	reaction	NN
cord-006860-a3b8hyyr	4890	4	of	of	IN
cord-006860-a3b8hyyr	4890	5	PL	PL	NNP
cord-006860-a3b8hyyr	4890	6	/	/	SYM
cord-006860-a3b8hyyr	4890	7	IM	IM	NNP
cord-006860-a3b8hyyr	4890	8	430	430	CD
cord-006860-a3b8hyyr	4890	9	with	with	IN
cord-006860-a3b8hyyr	4890	10	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	4890	11	and	and	CC
cord-006860-a3b8hyyr	4890	12	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	4890	13	suggests	suggest	VBZ
cord-006860-a3b8hyyr	4890	14	the	the	DT
cord-006860-a3b8hyyr	4890	15	possible	possible	JJ
cord-006860-a3b8hyyr	4890	16	presence	presence	NN
cord-006860-a3b8hyyr	4890	17	of	of	IN
cord-006860-a3b8hyyr	4890	18	distinct	distinct	JJ
cord-006860-a3b8hyyr	4890	19	sub	sub	NN
cord-006860-a3b8hyyr	4890	20	-	-	NNS
cord-006860-a3b8hyyr	4890	21	isoforms	isoform	NNS
cord-006860-a3b8hyyr	4890	22	of	of	IN
cord-006860-a3b8hyyr	4890	23	SERCA	SERCA	NNP
cord-006860-a3b8hyyr	4890	24	3	3	CD
cord-006860-a3b8hyyr	4890	25	with	with	IN
cord-006860-a3b8hyyr	4890	26	the	the	DT
cord-006860-a3b8hyyr	4890	27	PMNL	PMNL	NNP
cord-006860-a3b8hyyr	4890	28	and	and	CC
cord-006860-a3b8hyyr	4890	29	platelet	platelet	NN
cord-006860-a3b8hyyr	4890	30	proteins	protein	NNS
cord-006860-a3b8hyyr	4890	31	being	be	VBG
cord-006860-a3b8hyyr	4890	32	similar	similar	JJ
cord-006860-a3b8hyyr	4890	33	and	and	CC
cord-006860-a3b8hyyr	4890	34	different	different	JJ
cord-006860-a3b8hyyr	4890	35	to	to	IN
cord-006860-a3b8hyyr	4890	36	the	the	DT
cord-006860-a3b8hyyr	4890	37	SERCA	SERCA	NNP
cord-006860-a3b8hyyr	4890	38	3	3	CD
cord-006860-a3b8hyyr	4890	39	isoform	isoform	NN
cord-006860-a3b8hyyr	4890	40	present	present	NN
cord-006860-a3b8hyyr	4890	41	in	in	IN
cord-006860-a3b8hyyr	4890	42	HUVEC	HUVEC	NNP
cord-006860-a3b8hyyr	4890	43	.	.	.
cord-006860-a3b8hyyr	4891	1	Microvascular	microvascular	JJ
cord-006860-a3b8hyyr	4891	2	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4891	3	cell	cell	NN
cord-006860-a3b8hyyr	4891	4	(	(	-LRB-
cord-006860-a3b8hyyr	4891	5	EC	EC	NNP
cord-006860-a3b8hyyr	4891	6	)	)	-RRB-
cord-006860-a3b8hyyr	4891	7	lines	line	NNS
cord-006860-a3b8hyyr	4891	8	with	with	IN
cord-006860-a3b8hyyr	4891	9	a	a	DT
cord-006860-a3b8hyyr	4891	10	limited	limited	JJ
cord-006860-a3b8hyyr	4891	11	life	life	NN
cord-006860-a3b8hyyr	4891	12	span	span	NN
cord-006860-a3b8hyyr	4891	13	of	of	IN
cord-006860-a3b8hyyr	4891	14	2	2	CD
cord-006860-a3b8hyyr	4891	15	-	-	SYM
cord-006860-a3b8hyyr	4891	16	3	3	CD
cord-006860-a3b8hyyr	4891	17	months	month	NNS
cord-006860-a3b8hyyr	4891	18	in	in	IN
cord-006860-a3b8hyyr	4891	19	vitro	vitro	FW
cord-006860-a3b8hyyr	4891	20	were	be	VBD
cord-006860-a3b8hyyr	4891	21	established	establish	VBN
cord-006860-a3b8hyyr	4891	22	from	from	IN
cord-006860-a3b8hyyr	4891	23	human	human	JJ
cord-006860-a3b8hyyr	4891	24	bone	bone	NN
cord-006860-a3b8hyyr	4891	25	marrow	marrow	NN
cord-006860-a3b8hyyr	4891	26	,	,	,
cord-006860-a3b8hyyr	4891	27	skin	skin	NN
cord-006860-a3b8hyyr	4891	28	or	or	CC
cord-006860-a3b8hyyr	4891	29	solid	solid	JJ
cord-006860-a3b8hyyr	4891	30	tumor	tumor	NN
cord-006860-a3b8hyyr	4891	31	tissue	tissue	NN
cord-006860-a3b8hyyr	4891	32	.	.	.
cord-006860-a3b8hyyr	4892	1	Homogeneity	homogeneity	NN
cord-006860-a3b8hyyr	4892	2	of	of	IN
cord-006860-a3b8hyyr	4892	3	the	the	DT
cord-006860-a3b8hyyr	4892	4	lines	line	NNS
cord-006860-a3b8hyyr	4892	5	was	be	VBD
cord-006860-a3b8hyyr	4892	6	verified	verify	VBN
cord-006860-a3b8hyyr	4892	7	by	by	IN
cord-006860-a3b8hyyr	4892	8	flow	flow	NN
cord-006860-a3b8hyyr	4892	9	cytometric	cytometric	NNP
cord-006860-a3b8hyyr	4892	10	analysis	analysis	NN
cord-006860-a3b8hyyr	4892	11	and	and	CC
cord-006860-a3b8hyyr	4892	12	cytokine	cytokine	JJ
cord-006860-a3b8hyyr	4892	13	expression	expression	NN
cord-006860-a3b8hyyr	4892	14	patterns	pattern	NNS
cord-006860-a3b8hyyr	4892	15	.	.	.
cord-006860-a3b8hyyr	4893	1	The	the	DT
cord-006860-a3b8hyyr	4893	2	cultured	cultured	JJ
cord-006860-a3b8hyyr	4893	3	EC	EC	NNP
cord-006860-a3b8hyyr	4893	4	constitutively	constitutively	RB
cord-006860-a3b8hyyr	4893	5	expressed	express	VBD
cord-006860-a3b8hyyr	4894	1	HLA	HLA	NNP
cord-006860-a3b8hyyr	4894	2	-	-	HYPH
cord-006860-a3b8hyyr	4894	3	class	class	NN
cord-006860-a3b8hyyr	4894	4	I	i	NN
cord-006860-a3b8hyyr	4894	5	antigens	antigen	NNS
cord-006860-a3b8hyyr	4894	6	,	,	,
cord-006860-a3b8hyyr	4894	7	CD44	CD44	NNP
cord-006860-a3b8hyyr	4894	8	,	,	,
cord-006860-a3b8hyyr	4894	9	procollagen	procollagen	NNP
cord-006860-a3b8hyyr	4894	10	type	type	NN
cord-006860-a3b8hyyr	4894	11	I	I	NNP
cord-006860-a3b8hyyr	4894	12	,	,	,
cord-006860-a3b8hyyr	4894	13	CD62E	CD62E	NNP
cord-006860-a3b8hyyr	4894	14	,	,	,
cord-006860-a3b8hyyr	4894	15	CD34	CD34	NNP
cord-006860-a3b8hyyr	4894	16	,	,	,
cord-006860-a3b8hyyr	4894	17	and	and	CC
cord-006860-a3b8hyyr	4894	18	receptors	receptor	NNS
cord-006860-a3b8hyyr	4894	19	for	for	IN
cord-006860-a3b8hyyr	4894	20	granulocyte	granulocyte	NN
cord-006860-a3b8hyyr	4894	21	colony	colony	NN
cord-006860-a3b8hyyr	4894	22	stimulating	stimulate	VBG
cord-006860-a3b8hyyr	4894	23	factor	factor	NN
cord-006860-a3b8hyyr	4894	24	(	(	-LRB-
cord-006860-a3b8hyyr	4894	25	G	G	NNP
cord-006860-a3b8hyyr	4894	26	-	-	HYPH
cord-006860-a3b8hyyr	4894	27	CSF	CSF	NNP
cord-006860-a3b8hyyr	4894	28	)	)	-RRB-
cord-006860-a3b8hyyr	4894	29	.	.	.
cord-006860-a3b8hyyr	4895	1	Endothelial	endothelial	NN
cord-006860-a3b8hyyr	4895	2	cells	cell	NNS
cord-006860-a3b8hyyr	4895	3	constitutively	constitutively	RB
cord-006860-a3b8hyyr	4895	4	produced	produce	VBD
cord-006860-a3b8hyyr	4895	5	IL-6	IL-6	NNP
cord-006860-a3b8hyyr	4895	6	and	and	CC
cord-006860-a3b8hyyr	4895	7	IL-8	IL-8	NNP
cord-006860-a3b8hyyr	4895	8	as	as	RB
cord-006860-a3b8hyyr	4895	9	well	well	RB
cord-006860-a3b8hyyr	4895	10	as	as	IN
cord-006860-a3b8hyyr	4895	11	TPA	TPA	NNP
cord-006860-a3b8hyyr	4895	12	and	and	CC
cord-006860-a3b8hyyr	4895	13	PAI	PAI	NNP
cord-006860-a3b8hyyr	4895	14	-	-	HYPH
cord-006860-a3b8hyyr	4895	15	I	-PRON-	PRP
cord-006860-a3b8hyyr	4895	16	as	as	IN
cord-006860-a3b8hyyr	4895	17	determined	determine	VBN
cord-006860-a3b8hyyr	4895	18	by	by	IN
cord-006860-a3b8hyyr	4895	19	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	4895	20	.	.	.
cord-006860-a3b8hyyr	4896	1	In	in	IN
cord-006860-a3b8hyyr	4896	2	the	the	DT
cord-006860-a3b8hyyr	4896	3	presence	presence	NN
cord-006860-a3b8hyyr	4896	4	of	of	IN
cord-006860-a3b8hyyr	4896	5	5	5	CD
cord-006860-a3b8hyyr	4896	6	IU	IU	NNP
cord-006860-a3b8hyyr	4896	7	/	/	,
cord-006860-a3b8hyyr	4896	8	ml	ml	NN
cord-006860-a3b8hyyr	4896	9	of	of	IN
cord-006860-a3b8hyyr	4896	10	exogeneous	exogeneous	NNP
cord-006860-a3b8hyyr	4896	11	IL	IL	NNP
cord-006860-a3b8hyyr	4896	12	-	-	HYPH
cord-006860-a3b8hyyr	4896	13	la	la	NNP
cord-006860-a3b8hyyr	4896	14	,	,	,
cord-006860-a3b8hyyr	4896	15	G	G	NNP
cord-006860-a3b8hyyr	4896	16	-	-	HYPH
cord-006860-a3b8hyyr	4896	17	CSF	CSF	NNP
cord-006860-a3b8hyyr	4896	18	was	be	VBD
cord-006860-a3b8hyyr	4896	19	secreted	secrete	VBN
cord-006860-a3b8hyyr	4896	20	at	at	IN
cord-006860-a3b8hyyr	4896	21	high	high	JJ
cord-006860-a3b8hyyr	4896	22	amounts	amount	NNS
cord-006860-a3b8hyyr	4896	23	(	(	-LRB-
cord-006860-a3b8hyyr	4896	24	lng	lng	NNP
cord-006860-a3b8hyyr	4896	25	/	/	SYM
cord-006860-a3b8hyyr	4896	26	ml	ml	NNP
cord-006860-a3b8hyyr	4896	27	)	)	-RRB-
cord-006860-a3b8hyyr	4896	28	and	and	CC
cord-006860-a3b8hyyr	4896	29	GM	GM	NNP
cord-006860-a3b8hyyr	4896	30	-	-	HYPH
cord-006860-a3b8hyyr	4896	31	CSF	CSF	NNP
cord-006860-a3b8hyyr	4896	32	at	at	IN
cord-006860-a3b8hyyr	4896	33	low	low	JJ
cord-006860-a3b8hyyr	4896	34	amounts	amount	NNS
cord-006860-a3b8hyyr	4896	35	(	(	-LRB-
cord-006860-a3b8hyyr	4896	36	15pg	15pg	JJ
cord-006860-a3b8hyyr	4896	37	/	/	SYM
cord-006860-a3b8hyyr	4896	38	ml	ml	NN
cord-006860-a3b8hyyr	4896	39	)	)	-RRB-
cord-006860-a3b8hyyr	4896	40	in	in	IN
cord-006860-a3b8hyyr	4896	41	confluent	confluent	JJ
cord-006860-a3b8hyyr	4896	42	monolayers	monolayer	NNS
cord-006860-a3b8hyyr	4896	43	and	and	CC
cord-006860-a3b8hyyr	4896	44	during	during	IN
cord-006860-a3b8hyyr	4896	45	over	over	IN
cord-006860-a3b8hyyr	4896	46	night	night	NN
cord-006860-a3b8hyyr	4896	47	incubation	incubation	NN
cord-006860-a3b8hyyr	4896	48	.	.	.
cord-006860-a3b8hyyr	4897	1	These	these	DT
cord-006860-a3b8hyyr	4897	2	EC	EC	NNP
cord-006860-a3b8hyyr	4897	3	potently	potently	RB
cord-006860-a3b8hyyr	4897	4	bound	bind	VBD
cord-006860-a3b8hyyr	4897	5	to	to	IN
cord-006860-a3b8hyyr	4897	6	isolated	isolate	VBN
cord-006860-a3b8hyyr	4897	7	neutrophilic	neutrophilic	JJ
cord-006860-a3b8hyyr	4897	8	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4897	9	.	.	.
cord-006860-a3b8hyyr	4898	1	When	when	WRB
cord-006860-a3b8hyyr	4898	2	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4898	3	were	be	VBD
cord-006860-a3b8hyyr	4898	4	stimulated	stimulate	VBN
cord-006860-a3b8hyyr	4898	5	by	by	IN
cord-006860-a3b8hyyr	4898	6	either	either	DT
cord-006860-a3b8hyyr	4898	7	10~	10~	CD
cord-006860-a3b8hyyr	4898	8	4	4	CD
cord-006860-a3b8hyyr	4898	9	or	or	CC
cord-006860-a3b8hyyr	4898	10	10	10	CD
cord-006860-a3b8hyyr	4898	11	.7	.7	.
cord-006860-a3b8hyyr	4899	1	M	M	NNP
cord-006860-a3b8hyyr	4899	2	formyl	formyl	NNP
cord-006860-a3b8hyyr	4899	3	-	-	HYPH
cord-006860-a3b8hyyr	4899	4	methionyl	methionyl	NNP
cord-006860-a3b8hyyr	4899	5	-	-	HYPH
cord-006860-a3b8hyyr	4899	6	leucyl	leucyl	JJ
cord-006860-a3b8hyyr	4899	7	-	-	HYPH
cord-006860-a3b8hyyr	4899	8	phenylanaline	phenylanaline	JJ
cord-006860-a3b8hyyr	4899	9	(	(	-LRB-
cord-006860-a3b8hyyr	4899	10	fMLP	fmlp	NN
cord-006860-a3b8hyyr	4899	11	)	)	-RRB-
cord-006860-a3b8hyyr	4900	1	to	to	TO
cord-006860-a3b8hyyr	4900	2	produce	produce	VB
cord-006860-a3b8hyyr	4900	3	oxygen	oxygen	NN
cord-006860-a3b8hyyr	4900	4	radicals	radical	NNS
cord-006860-a3b8hyyr	4900	5	,	,	,
cord-006860-a3b8hyyr	4900	6	the	the	DT
cord-006860-a3b8hyyr	4900	7	preincubation	preincubation	NN
cord-006860-a3b8hyyr	4900	8	with	with	IN
cord-006860-a3b8hyyr	4900	9	a	a	DT
cord-006860-a3b8hyyr	4900	10	single	single	JJ
cord-006860-a3b8hyyr	4900	11	cell	cell	NN
cord-006860-a3b8hyyr	4900	12	suspension	suspension	NN
cord-006860-a3b8hyyr	4900	13	of	of	IN
cord-006860-a3b8hyyr	4900	14	EC	EC	NNP
cord-006860-a3b8hyyr	4900	15	caused	cause	VBD
cord-006860-a3b8hyyr	4900	16	oxygen	oxygen	NN
cord-006860-a3b8hyyr	4900	17	radical	radical	JJ
cord-006860-a3b8hyyr	4900	18	scavenging	scavenging	NN
cord-006860-a3b8hyyr	4900	19	.	.	.
cord-006860-a3b8hyyr	4901	1	A	a	DT
cord-006860-a3b8hyyr	4901	2	ratio	ratio	NN
cord-006860-a3b8hyyr	4901	3	of	of	IN
cord-006860-a3b8hyyr	4901	4	1	1	CD
cord-006860-a3b8hyyr	4901	5	:	:	SYM
cord-006860-a3b8hyyr	4901	6	100	100	CD
cord-006860-a3b8hyyr	4901	7	EC	EC	NNP
cord-006860-a3b8hyyr	4901	8	to	to	IN
cord-006860-a3b8hyyr	4901	9	neutrophilic	neutrophilic	NNP
cord-006860-a3b8hyyr	4901	10	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4901	11	resulted	result	VBD
cord-006860-a3b8hyyr	4901	12	in	in	IN
cord-006860-a3b8hyyr	4901	13	a	a	DT
cord-006860-a3b8hyyr	4901	14	50	50	CD
cord-006860-a3b8hyyr	4901	15	_	_	NN
cord-006860-a3b8hyyr	4901	16	_	_	NN
cord-006860-a3b8hyyr	4901	17	+	+	CC
cord-006860-a3b8hyyr	4901	18	10	10	CD
cord-006860-a3b8hyyr	4901	19	%	%	NN
cord-006860-a3b8hyyr	4901	20	inhibition	inhibition	NN
cord-006860-a3b8hyyr	4901	21	of	of	IN
cord-006860-a3b8hyyr	4901	22	fMLP	fmlp	NN
cord-006860-a3b8hyyr	4901	23	-	-	HYPH
cord-006860-a3b8hyyr	4901	24	induced	induce	VBN
cord-006860-a3b8hyyr	4901	25	and	and	CC
cord-006860-a3b8hyyr	4901	26	luminol	luminol	NN
cord-006860-a3b8hyyr	4901	27	-	-	HYPH
cord-006860-a3b8hyyr	4901	28	enhanced	enhance	VBN
cord-006860-a3b8hyyr	4901	29	chemiluminescence	chemiluminescence	NN
cord-006860-a3b8hyyr	4901	30	in	in	IN
cord-006860-a3b8hyyr	4901	31	vitro	vitro	FW
cord-006860-a3b8hyyr	4901	32	.	.	.
cord-006860-a3b8hyyr	4902	1	This	this	DT
cord-006860-a3b8hyyr	4902	2	effect	effect	NN
cord-006860-a3b8hyyr	4902	3	was	be	VBD
cord-006860-a3b8hyyr	4902	4	probably	probably	RB
cord-006860-a3b8hyyr	4902	5	due	due	JJ
cord-006860-a3b8hyyr	4902	6	to	to	IN
cord-006860-a3b8hyyr	4902	7	the	the	DT
cord-006860-a3b8hyyr	4902	8	constitutive	constitutive	JJ
cord-006860-a3b8hyyr	4902	9	nitrogen	nitrogen	NN
cord-006860-a3b8hyyr	4902	10	oxide	oxide	NN
cord-006860-a3b8hyyr	4902	11	(	(	-LRB-
cord-006860-a3b8hyyr	4902	12	NO	no	UH
cord-006860-a3b8hyyr	4902	13	)	)	-RRB-
cord-006860-a3b8hyyr	4902	14	production	production	NN
cord-006860-a3b8hyyr	4902	15	by	by	IN
cord-006860-a3b8hyyr	4902	16	EC	EC	NNP
cord-006860-a3b8hyyr	4902	17	.	.	.
cord-006860-a3b8hyyr	4903	1	Unexpectedly	unexpectedly	RB
cord-006860-a3b8hyyr	4903	2	,	,	,
cord-006860-a3b8hyyr	4903	3	preincubation	preincubation	NN
cord-006860-a3b8hyyr	4903	4	of	of	IN
cord-006860-a3b8hyyr	4903	5	EC	EC	NNP
cord-006860-a3b8hyyr	4903	6	with	with	IN
cord-006860-a3b8hyyr	4903	7	50	50	CD
cord-006860-a3b8hyyr	4903	8	IU	IU	NNP
cord-006860-a3b8hyyr	4903	9	/	/	,
cord-006860-a3b8hyyr	4903	10	ml	ml	NNS
cord-006860-a3b8hyyr	4903	11	of	of	IN
cord-006860-a3b8hyyr	4903	12	interferon	interferon	NNP
cord-006860-a3b8hyyr	4903	13	-	-	HYPH
cord-006860-a3b8hyyr	4903	14	y	y	NNP
cord-006860-a3b8hyyr	4903	15	(	(	-LRB-
cord-006860-a3b8hyyr	4903	16	IFN	IFN	NNP
cord-006860-a3b8hyyr	4903	17	-	-	HYPH
cord-006860-a3b8hyyr	4903	18	y	y	NNP
cord-006860-a3b8hyyr	4903	19	)	)	-RRB-
cord-006860-a3b8hyyr	4903	20	to	to	TO
cord-006860-a3b8hyyr	4903	21	increase	increase	VB
cord-006860-a3b8hyyr	4903	22	NO	no	JJ
cord-006860-a3b8hyyr	4903	23	-	-	HYPH
cord-006860-a3b8hyyr	4903	24	secretion	secretion	NN
cord-006860-a3b8hyyr	4903	25	did	do	VBD
cord-006860-a3b8hyyr	4903	26	not	not	RB
cord-006860-a3b8hyyr	4903	27	alter	alter	VB
cord-006860-a3b8hyyr	4903	28	the	the	DT
cord-006860-a3b8hyyr	4903	29	extent	extent	NN
cord-006860-a3b8hyyr	4903	30	of	of	IN
cord-006860-a3b8hyyr	4903	31	the	the	DT
cord-006860-a3b8hyyr	4903	32	oxygen	oxygen	NN
cord-006860-a3b8hyyr	4903	33	scavenging	scavenging	NN
cord-006860-a3b8hyyr	4903	34	effect	effect	NN
cord-006860-a3b8hyyr	4903	35	measured	measure	VBN
cord-006860-a3b8hyyr	4903	36	at	at	IN
cord-006860-a3b8hyyr	4903	37	different	different	JJ
cord-006860-a3b8hyyr	4903	38	ratios	ratio	NNS
cord-006860-a3b8hyyr	4903	39	of	of	IN
cord-006860-a3b8hyyr	4903	40	EC	EC	NNP
cord-006860-a3b8hyyr	4903	41	to	to	IN
cord-006860-a3b8hyyr	4903	42	neutrophilic	neutrophilic	NNP
cord-006860-a3b8hyyr	4903	43	granulocytes	granulocyte	NNS
cord-006860-a3b8hyyr	4903	44	.	.	.
cord-006860-a3b8hyyr	4904	1	According	accord	VBG
cord-006860-a3b8hyyr	4904	2	to	to	IN
cord-006860-a3b8hyyr	4904	3	the	the	DT
cord-006860-a3b8hyyr	4904	4	surface	surface	NN
cord-006860-a3b8hyyr	4904	5	antigen	antigen	NN
cord-006860-a3b8hyyr	4904	6	expression	expression	NN
cord-006860-a3b8hyyr	4904	7	pattern	pattern	NN
cord-006860-a3b8hyyr	4904	8	,	,	,
cord-006860-a3b8hyyr	4904	9	identical	identical	JJ
cord-006860-a3b8hyyr	4904	10	IFN	IFN	NNP
cord-006860-a3b8hyyr	4904	11	-	-	HYPH
cord-006860-a3b8hyyr	4904	12	F	F	NNP
cord-006860-a3b8hyyr	4904	13	treatment	treatment	NN
cord-006860-a3b8hyyr	4904	14	upregulated	upregulate	VBD
cord-006860-a3b8hyyr	4904	15	adhesion	adhesion	NN
cord-006860-a3b8hyyr	4904	16	receptors	receptor	NNS
cord-006860-a3b8hyyr	4904	17	on	on	IN
cord-006860-a3b8hyyr	4904	18	EC	EC	NNP
cord-006860-a3b8hyyr	4904	19	.	.	.
cord-006860-a3b8hyyr	4905	1	Concomitantly	concomitantly	RB
cord-006860-a3b8hyyr	4905	2	,	,	,
cord-006860-a3b8hyyr	4905	3	binding	bind	VBG
cord-006860-a3b8hyyr	4905	4	of	of	IN
cord-006860-a3b8hyyr	4905	5	neutrophils	neutrophil	NNS
cord-006860-a3b8hyyr	4905	6	to	to	IN
cord-006860-a3b8hyyr	4905	7	EC	EC	NNP
cord-006860-a3b8hyyr	4905	8	was	be	VBD
cord-006860-a3b8hyyr	4905	9	significantly	significantly	RB
cord-006860-a3b8hyyr	4905	10	increased	increase	VBN
cord-006860-a3b8hyyr	4905	11	.	.	.
cord-006860-a3b8hyyr	4906	1	Thus	thus	RB
cord-006860-a3b8hyyr	4906	2	,	,	,
cord-006860-a3b8hyyr	4906	3	the	the	DT
cord-006860-a3b8hyyr	4906	4	net	net	JJ
cord-006860-a3b8hyyr	4906	5	oxygen	oxygen	NN
cord-006860-a3b8hyyr	4906	6	-	-	HYPH
cord-006860-a3b8hyyr	4906	7	scavenging	scavenging	NN
cord-006860-a3b8hyyr	4906	8	effect	effect	NN
cord-006860-a3b8hyyr	4906	9	by	by	IN
cord-006860-a3b8hyyr	4906	10	EC	EC	NNP
cord-006860-a3b8hyyr	4906	11	appears	appear	VBZ
cord-006860-a3b8hyyr	4906	12	to	to	TO
cord-006860-a3b8hyyr	4906	13	be	be	VB
cord-006860-a3b8hyyr	4906	14	stable	stable	JJ
cord-006860-a3b8hyyr	4906	15	under	under	IN
cord-006860-a3b8hyyr	4906	16	the	the	DT
cord-006860-a3b8hyyr	4906	17	condition	condition	NN
cord-006860-a3b8hyyr	4906	18	of	of	IN
cord-006860-a3b8hyyr	4906	19	IFN	IFN	NNP
cord-006860-a3b8hyyr	4906	20	-	-	HYPH
cord-006860-a3b8hyyr	4906	21	y	y	NNP
cord-006860-a3b8hyyr	4906	22	stimulation	stimulation	NN
cord-006860-a3b8hyyr	4906	23	which	which	WDT
cord-006860-a3b8hyyr	4906	24	indicates	indicate	VBZ
cord-006860-a3b8hyyr	4906	25	maintenance	maintenance	NN
cord-006860-a3b8hyyr	4906	26	of	of	IN
cord-006860-a3b8hyyr	4906	27	EC	EC	NNP
cord-006860-a3b8hyyr	4906	28	function	function	NN
cord-006860-a3b8hyyr	4906	29	and	and	CC
cord-006860-a3b8hyyr	4906	30	effective	effective	JJ
cord-006860-a3b8hyyr	4906	31	neutralizition	neutralizition	NN
cord-006860-a3b8hyyr	4906	32	of	of	IN
cord-006860-a3b8hyyr	4906	33	non	non	JJ
cord-006860-a3b8hyyr	4906	34	-	-	JJ
cord-006860-a3b8hyyr	4906	35	specific	specific	JJ
cord-006860-a3b8hyyr	4906	36	oxygen	oxygen	NN
cord-006860-a3b8hyyr	4906	37	radical	radical	JJ
cord-006860-a3b8hyyr	4906	38	damage	damage	NN
cord-006860-a3b8hyyr	4906	39	.	.	.
cord-006860-a3b8hyyr	4907	1	Moreover	moreover	RB
cord-006860-a3b8hyyr	4907	2	,	,	,
cord-006860-a3b8hyyr	4907	3	the	the	DT
cord-006860-a3b8hyyr	4907	4	established	establish	VBN
cord-006860-a3b8hyyr	4907	5	test	test	NN
cord-006860-a3b8hyyr	4907	6	system	system	NN
cord-006860-a3b8hyyr	4907	7	can	can	MD
cord-006860-a3b8hyyr	4907	8	be	be	VB
cord-006860-a3b8hyyr	4907	9	useful	useful	JJ
cord-006860-a3b8hyyr	4907	10	to	to	TO
cord-006860-a3b8hyyr	4907	11	investigate	investigate	VB
cord-006860-a3b8hyyr	4907	12	the	the	DT
cord-006860-a3b8hyyr	4907	13	selective	selective	JJ
cord-006860-a3b8hyyr	4907	14	contribution	contribution	NN
cord-006860-a3b8hyyr	4907	15	of	of	IN
cord-006860-a3b8hyyr	4907	16	other	other	JJ
cord-006860-a3b8hyyr	4907	17	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	4907	18	cytokines	cytokine	NNS
cord-006860-a3b8hyyr	4907	19	,	,	,
cord-006860-a3b8hyyr	4907	20	adhesion	adhesion	NN
cord-006860-a3b8hyyr	4907	21	molecules	molecule	NNS
cord-006860-a3b8hyyr	4907	22	,	,	,
cord-006860-a3b8hyyr	4907	23	macrophages	macrophage	NNS
cord-006860-a3b8hyyr	4907	24	and	and	CC
cord-006860-a3b8hyyr	4907	25	platelets	platelet	NNS
cord-006860-a3b8hyyr	4907	26	on	on	IN
cord-006860-a3b8hyyr	4907	27	EC	EC	NNP
cord-006860-a3b8hyyr	4907	28	function	function	NN
cord-006860-a3b8hyyr	4907	29	in	in	IN
cord-006860-a3b8hyyr	4907	30	vitro	vitro	FW
cord-006860-a3b8hyyr	4907	31	.	.	.
cord-006860-a3b8hyyr	4908	1	Atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	4908	2	is	be	VBZ
cord-006860-a3b8hyyr	4908	3	characterized	characterize	VBN
cord-006860-a3b8hyyr	4908	4	by	by	IN
cord-006860-a3b8hyyr	4908	5	intimal	intimal	JJ
cord-006860-a3b8hyyr	4908	6	migration	migration	NN
cord-006860-a3b8hyyr	4908	7	and	and	CC
cord-006860-a3b8hyyr	4908	8	proliferation	proliferation	NN
cord-006860-a3b8hyyr	4908	9	of	of	IN
cord-006860-a3b8hyyr	4908	10	smooth	smooth	JJ
cord-006860-a3b8hyyr	4908	11	muscle	muscle	NN
cord-006860-a3b8hyyr	4908	12	cells	cell	NNS
cord-006860-a3b8hyyr	4908	13	(	(	-LRB-
cord-006860-a3b8hyyr	4908	14	SMCs	SMCs	NNP
cord-006860-a3b8hyyr	4908	15	)	)	-RRB-
cord-006860-a3b8hyyr	4908	16	,	,	,
cord-006860-a3b8hyyr	4908	17	by	by	IN
cord-006860-a3b8hyyr	4908	18	macrophage	macrophage	NN
cord-006860-a3b8hyyr	4908	19	infiltration	infiltration	NN
cord-006860-a3b8hyyr	4908	20	and	and	CC
cord-006860-a3b8hyyr	4908	21	extracellular	extracellular	JJ
cord-006860-a3b8hyyr	4908	22	matrix	matrix	NN
cord-006860-a3b8hyyr	4908	23	remodeling	remodeling	NN
cord-006860-a3b8hyyr	4908	24	.	.	.
cord-006860-a3b8hyyr	4909	1	Circumstantial	circumstantial	JJ
cord-006860-a3b8hyyr	4909	2	evidence	evidence	NN
cord-006860-a3b8hyyr	4909	3	suggests	suggest	VBZ
cord-006860-a3b8hyyr	4909	4	that	that	IN
cord-006860-a3b8hyyr	4909	5	urokinasetype	urokinasetype	NNP
cord-006860-a3b8hyyr	4909	6	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4909	7	activator	activator	NN
cord-006860-a3b8hyyr	4909	8	(	(	-LRB-
cord-006860-a3b8hyyr	4909	9	UPA	UPA	NNP
cord-006860-a3b8hyyr	4909	10	)	)	-RRB-
cord-006860-a3b8hyyr	4909	11	may	may	MD
cord-006860-a3b8hyyr	4909	12	be	be	VB
cord-006860-a3b8hyyr	4909	13	relevant	relevant	JJ
cord-006860-a3b8hyyr	4909	14	in	in	IN
cord-006860-a3b8hyyr	4909	15	these	these	DT
cord-006860-a3b8hyyr	4909	16	processes	process	NNS
cord-006860-a3b8hyyr	4909	17	.	.	.
cord-006860-a3b8hyyr	4910	1	This	this	DT
cord-006860-a3b8hyyr	4910	2	study	study	NN
cord-006860-a3b8hyyr	4910	3	examines	examine	VBZ
cord-006860-a3b8hyyr	4910	4	UPA	UPA	NNP
cord-006860-a3b8hyyr	4910	5	expression	expression	NN
cord-006860-a3b8hyyr	4910	6	and	and	CC
cord-006860-a3b8hyyr	4910	7	UPA	UPA	NNP
cord-006860-a3b8hyyr	4910	8	antigen	antigen	NN
cord-006860-a3b8hyyr	4910	9	localization	localization	NN
cord-006860-a3b8hyyr	4910	10	in	in	IN
cord-006860-a3b8hyyr	4910	11	human	human	JJ
cord-006860-a3b8hyyr	4910	12	coronary	coronary	JJ
cord-006860-a3b8hyyr	4910	13	arteries	artery	NNS
cord-006860-a3b8hyyr	4910	14	with	with	IN
cord-006860-a3b8hyyr	4910	15	,	,	,
cord-006860-a3b8hyyr	4910	16	carious	carious	JJ
cord-006860-a3b8hyyr	4910	17	degrees	degree	NNS
cord-006860-a3b8hyyr	4910	18	of	of	IN
cord-006860-a3b8hyyr	4910	19	atherosclerotic	atherosclerotic	JJ
cord-006860-a3b8hyyr	4910	20	lesions	lesion	NNS
cord-006860-a3b8hyyr	4910	21	.	.	.
cord-006860-a3b8hyyr	4911	1	Representative	representative	JJ
cord-006860-a3b8hyyr	4911	2	segments	segment	NNS
cord-006860-a3b8hyyr	4911	3	of	of	IN
cord-006860-a3b8hyyr	4911	4	macroscopically	macroscopically	RB
cord-006860-a3b8hyyr	4911	5	normal	normal	JJ
cord-006860-a3b8hyyr	4911	6	areas	area	NNS
cord-006860-a3b8hyyr	4911	7	(	(	-LRB-
cord-006860-a3b8hyyr	4911	8	MNAs	MNAs	NNPS
cord-006860-a3b8hyyr	4911	9	)	)	-RRB-
cord-006860-a3b8hyyr	4911	10	,	,	,
cord-006860-a3b8hyyr	4911	11	early	early	JJ
cord-006860-a3b8hyyr	4911	12	lesions	lesion	NNS
cord-006860-a3b8hyyr	4911	13	(	(	-LRB-
cord-006860-a3b8hyyr	4911	14	ELs	ELs	NNP
cord-006860-a3b8hyyr	4911	15	)	)	-RRB-
cord-006860-a3b8hyyr	4911	16	and	and	CC
cord-006860-a3b8hyyr	4911	17	fibrous	fibrous	JJ
cord-006860-a3b8hyyr	4911	18	plaques	plaque	NNS
cord-006860-a3b8hyyr	4911	19	(	(	-LRB-
cord-006860-a3b8hyyr	4911	20	FPs	fp	NNS
cord-006860-a3b8hyyr	4911	21	)	)	-RRB-
cord-006860-a3b8hyyr	4911	22	were	be	VBD
cord-006860-a3b8hyyr	4911	23	processed	process	VBN
cord-006860-a3b8hyyr	4911	24	in	in	IN
cord-006860-a3b8hyyr	4911	25	parallel	parallel	NN
cord-006860-a3b8hyyr	4911	26	for	for	IN
cord-006860-a3b8hyyr	4911	27	in	in	IN
cord-006860-a3b8hyyr	4911	28	situ	situ	JJ
cord-006860-a3b8hyyr	4911	29	hybddization	hybddization	NN
cord-006860-a3b8hyyr	4911	30	and	and	CC
cord-006860-a3b8hyyr	4911	31	immunohistochemical	immunohistochemical	JJ
cord-006860-a3b8hyyr	4911	32	analysis	analysis	NN
cord-006860-a3b8hyyr	4911	33	.	.	.
cord-006860-a3b8hyyr	4912	1	In	in	IN
cord-006860-a3b8hyyr	4912	2	MNAs	mna	NNS
cord-006860-a3b8hyyr	4912	3	,	,	,
cord-006860-a3b8hyyr	4912	4	UPA	UPA	NNP
cord-006860-a3b8hyyr	4912	5	was	be	VBD
cord-006860-a3b8hyyr	4912	6	detected	detect	VBN
cord-006860-a3b8hyyr	4912	7	both	both	CC
cord-006860-a3b8hyyr	4912	8	in	in	IN
cord-006860-a3b8hyyr	4912	9	the	the	DT
cord-006860-a3b8hyyr	4912	10	luminal	luminal	JJ
cord-006860-a3b8hyyr	4912	11	endothelium	endothelium	NN
cord-006860-a3b8hyyr	4912	12	and	and	CC
cord-006860-a3b8hyyr	4912	13	in	in	IN
cord-006860-a3b8hyyr	4912	14	celocalization	celocalization	NN
cord-006860-a3b8hyyr	4912	15	with	with	IN
cord-006860-a3b8hyyr	4912	16	~-actin	~-actin	NN
cord-006860-a3b8hyyr	4912	17	-	-	HYPH
cord-006860-a3b8hyyr	4912	18	positive	positive	JJ
cord-006860-a3b8hyyr	4912	19	SMCs	smc	NNS
cord-006860-a3b8hyyr	4912	20	throughout	throughout	IN
cord-006860-a3b8hyyr	4912	21	the	the	DT
cord-006860-a3b8hyyr	4912	22	tunica	tunica	NNP
cord-006860-a3b8hyyr	4912	23	media	medium	NNS
cord-006860-a3b8hyyr	4912	24	.	.	.
cord-006860-a3b8hyyr	4913	1	In	in	IN
cord-006860-a3b8hyyr	4913	2	ELs	el	NNS
cord-006860-a3b8hyyr	4913	3	,	,	,
cord-006860-a3b8hyyr	4913	4	UPA	UPA	NNP
cord-006860-a3b8hyyr	4913	5	mRNA	mrna	NN
cord-006860-a3b8hyyr	4913	6	and	and	CC
cord-006860-a3b8hyyr	4913	7	antigen	antigen	NN
cord-006860-a3b8hyyr	4913	8	were	be	VBD
cord-006860-a3b8hyyr	4913	9	substantially	substantially	RB
cord-006860-a3b8hyyr	4913	10	reduced	reduce	VBN
cord-006860-a3b8hyyr	4913	11	in	in	IN
cord-006860-a3b8hyyr	4913	12	the	the	DT
cord-006860-a3b8hyyr	4913	13	luminal	luminal	JJ
cord-006860-a3b8hyyr	4913	14	endothelium	endothelium	NN
cord-006860-a3b8hyyr	4913	15	.	.	.
cord-006860-a3b8hyyr	4914	1	However	however	RB
cord-006860-a3b8hyyr	4914	2	,	,	,
cord-006860-a3b8hyyr	4914	3	cellular	cellular	JJ
cord-006860-a3b8hyyr	4914	4	UPA	UPA	NNP
cord-006860-a3b8hyyr	4914	5	expression	expression	NN
cord-006860-a3b8hyyr	4914	6	was	be	VBD
cord-006860-a3b8hyyr	4914	7	detected	detect	VBN
cord-006860-a3b8hyyr	4914	8	in	in	IN
cord-006860-a3b8hyyr	4914	9	the	the	DT
cord-006860-a3b8hyyr	4914	10	subendothelial	subendothelial	JJ
cord-006860-a3b8hyyr	4914	11	area	area	NN
cord-006860-a3b8hyyr	4914	12	in	in	IN
cord-006860-a3b8hyyr	4914	13	colocalization	colocalization	NN
cord-006860-a3b8hyyr	4914	14	with	with	IN
cord-006860-a3b8hyyr	4914	15	tissue	tissue	NN
cord-006860-a3b8hyyr	4914	16	-	-	HYPH
cord-006860-a3b8hyyr	4914	17	infiltrating	infiltrate	VBG
cord-006860-a3b8hyyr	4914	18	CD68positive	cd68positive	JJ
cord-006860-a3b8hyyr	4914	19	macrophages	macrophage	NNS
cord-006860-a3b8hyyr	4914	20	.	.	.
cord-006860-a3b8hyyr	4915	1	In	in	IN
cord-006860-a3b8hyyr	4915	2	the	the	DT
cord-006860-a3b8hyyr	4915	3	deeper	deeply	RBR
cord-006860-a3b8hyyr	4915	4	intimal	intimal	JJ
cord-006860-a3b8hyyr	4915	5	and	and	CC
cord-006860-a3b8hyyr	4915	6	in	in	IN
cord-006860-a3b8hyyr	4915	7	the	the	DT
cord-006860-a3b8hyyr	4915	8	medial	medial	JJ
cord-006860-a3b8hyyr	4915	9	layers	layer	NNS
cord-006860-a3b8hyyr	4915	10	strong	strong	JJ
cord-006860-a3b8hyyr	4915	11	UPA	UPA	NNP
cord-006860-a3b8hyyr	4915	12	expression	expression	NN
cord-006860-a3b8hyyr	4915	13	was	be	VBD
cord-006860-a3b8hyyr	4915	14	observed	observe	VBN
cord-006860-a3b8hyyr	4915	15	in	in	IN
cord-006860-a3b8hyyr	4915	16	association	association	NN
cord-006860-a3b8hyyr	4915	17	with	with	IN
cord-006860-a3b8hyyr	4915	18	~-actinpositive	~-actinpositive	NNP
cord-006860-a3b8hyyr	4915	19	SMCs	smc	NNS
cord-006860-a3b8hyyr	4915	20	,	,	,
cord-006860-a3b8hyyr	4915	21	with	with	IN
cord-006860-a3b8hyyr	4915	22	most	most	JJS
cord-006860-a3b8hyyr	4915	23	of	of	IN
cord-006860-a3b8hyyr	4915	24	the	the	DT
cord-006860-a3b8hyyr	4915	25	UPA	UPA	NNP
cord-006860-a3b8hyyr	4915	26	-	-	HYPH
cord-006860-a3b8hyyr	4915	27	positive	positive	JJ
cord-006860-a3b8hyyr	4915	28	cells	cell	NNS
cord-006860-a3b8hyyr	4915	29	being	be	VBG
cord-006860-a3b8hyyr	4915	30	located	locate	VBN
cord-006860-a3b8hyyr	4915	31	in	in	IN
cord-006860-a3b8hyyr	4915	32	areas	area	NNS
cord-006860-a3b8hyyr	4915	33	with	with	IN
cord-006860-a3b8hyyr	4915	34	a	a	DT
cord-006860-a3b8hyyr	4915	35	high	high	JJ
cord-006860-a3b8hyyr	4915	36	proliferative	proliferative	JJ
cord-006860-a3b8hyyr	4915	37	activity	activity	NN
cord-006860-a3b8hyyr	4915	38	as	as	IN
cord-006860-a3b8hyyr	4915	39	detected	detect	VBN
cord-006860-a3b8hyyr	4915	40	by	by	IN
cord-006860-a3b8hyyr	4915	41	PCNA	PCNA	NNP
cord-006860-a3b8hyyr	4915	42	staining	stain	VBG
cord-006860-a3b8hyyr	4915	43	.	.	.
cord-006860-a3b8hyyr	4916	1	In	in	IN
cord-006860-a3b8hyyr	4916	2	FPs	fp	NNS
cord-006860-a3b8hyyr	4916	3	,	,	,
cord-006860-a3b8hyyr	4916	4	UPA	UPA	NNP
cord-006860-a3b8hyyr	4916	5	mRNA	mrna	NN
cord-006860-a3b8hyyr	4916	6	was	be	VBD
cord-006860-a3b8hyyr	4916	7	widely	widely	RB
cord-006860-a3b8hyyr	4916	8	expressed	express	VBN
cord-006860-a3b8hyyr	4916	9	in	in	IN
cord-006860-a3b8hyyr	4916	10	macrophage	macrophage	NN
cord-006860-a3b8hyyr	4916	11	-	-	HYPH
cord-006860-a3b8hyyr	4916	12	containing	contain	VBG
cord-006860-a3b8hyyr	4916	13	areas	area	NNS
cord-006860-a3b8hyyr	4916	14	within	within	IN
cord-006860-a3b8hyyr	4916	15	the	the	DT
cord-006860-a3b8hyyr	4916	16	fibrous	fibrous	JJ
cord-006860-a3b8hyyr	4916	17	cap	cap	NN
cord-006860-a3b8hyyr	4916	18	and	and	CC
cord-006860-a3b8hyyr	4916	19	at	at	IN
cord-006860-a3b8hyyr	4916	20	the	the	DT
cord-006860-a3b8hyyr	4916	21	periphery	periphery	NN
cord-006860-a3b8hyyr	4916	22	of	of	IN
cord-006860-a3b8hyyr	4916	23	the	the	DT
cord-006860-a3b8hyyr	4916	24	necrotic	necrotic	JJ
cord-006860-a3b8hyyr	4916	25	core	core	NN
cord-006860-a3b8hyyr	4916	26	of	of	IN
cord-006860-a3b8hyyr	4916	27	the	the	DT
cord-006860-a3b8hyyr	4916	28	lesions	lesion	NNS
cord-006860-a3b8hyyr	4916	29	.	.	.
cord-006860-a3b8hyyr	4917	1	In	in	IN
cord-006860-a3b8hyyr	4917	2	addition	addition	NN
cord-006860-a3b8hyyr	4917	3	,	,	,
cord-006860-a3b8hyyr	4917	4	UPA	UPA	NNP
cord-006860-a3b8hyyr	4917	5	antigen	antigen	NN
cord-006860-a3b8hyyr	4917	6	was	be	VBD
cord-006860-a3b8hyyr	4917	7	identified	identify	VBN
cord-006860-a3b8hyyr	4917	8	in	in	IN
cord-006860-a3b8hyyr	4917	9	acellular	acellular	JJ
cord-006860-a3b8hyyr	4917	10	areas	area	NNS
cord-006860-a3b8hyyr	4917	11	of	of	IN
cord-006860-a3b8hyyr	4917	12	the	the	DT
cord-006860-a3b8hyyr	4917	13	necrotic	necrotic	JJ
cord-006860-a3b8hyyr	4917	14	core	core	NN
cord-006860-a3b8hyyr	4917	15	regions	region	NNS
cord-006860-a3b8hyyr	4917	16	.	.	.
cord-006860-a3b8hyyr	4918	1	Compared	compare	VBN
cord-006860-a3b8hyyr	4918	2	to	to	IN
cord-006860-a3b8hyyr	4918	3	the	the	DT
cord-006860-a3b8hyyr	4918	4	diseased	diseased	JJ
cord-006860-a3b8hyyr	4918	5	intima	intima	NN
cord-006860-a3b8hyyr	4918	6	of	of	IN
cord-006860-a3b8hyyr	4918	7	these	these	DT
cord-006860-a3b8hyyr	4918	8	lesions	lesion	NNS
cord-006860-a3b8hyyr	4918	9	,	,	,
cord-006860-a3b8hyyr	4918	10	the	the	DT
cord-006860-a3b8hyyr	4918	11	adjacent	adjacent	JJ
cord-006860-a3b8hyyr	4918	12	media	medium	NNS
cord-006860-a3b8hyyr	4918	13	stained	stain	VBN
cord-006860-a3b8hyyr	4918	14	only	only	RB
cord-006860-a3b8hyyr	4918	15	weakly	weakly	RB
cord-006860-a3b8hyyr	4918	16	for	for	IN
cord-006860-a3b8hyyr	4918	17	UPA	UPA	NNP
cord-006860-a3b8hyyr	4918	18	.	.	.
cord-006860-a3b8hyyr	4919	1	In	in	IN
cord-006860-a3b8hyyr	4919	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	4919	3	,	,	,
cord-006860-a3b8hyyr	4919	4	this	this	DT
cord-006860-a3b8hyyr	4919	5	study	study	NN
cord-006860-a3b8hyyr	4919	6	demonstrates	demonstrate	VBZ
cord-006860-a3b8hyyr	4919	7	an	an	DT
cord-006860-a3b8hyyr	4919	8	enhanced	enhanced	JJ
cord-006860-a3b8hyyr	4919	9	expression	expression	NN
cord-006860-a3b8hyyr	4919	10	and	and	CC
cord-006860-a3b8hyyr	4919	11	synthesis	synthesis	NN
cord-006860-a3b8hyyr	4919	12	of	of	IN
cord-006860-a3b8hyyr	4919	13	UPA	UPA	NNP
cord-006860-a3b8hyyr	4919	14	by	by	IN
cord-006860-a3b8hyyr	4919	15	intimal	intimal	JJ
cord-006860-a3b8hyyr	4919	16	SMCs	SMCs	NNP
cord-006860-a3b8hyyr	4919	17	and	and	CC
cord-006860-a3b8hyyr	4919	18	macrophages	macrophage	NNS
cord-006860-a3b8hyyr	4919	19	in	in	IN
cord-006860-a3b8hyyr	4919	20	advanced	advanced	JJ
cord-006860-a3b8hyyr	4919	21	atherosclerotic	atherosclerotic	JJ
cord-006860-a3b8hyyr	4919	22	lesions	lesion	NNS
cord-006860-a3b8hyyr	4919	23	of	of	IN
cord-006860-a3b8hyyr	4919	24	human	human	JJ
cord-006860-a3b8hyyr	4919	25	coronary	coronary	NN
cord-006860-a3b8hyyr	4919	26	artedes	artede	NNS
cord-006860-a3b8hyyr	4919	27	These	these	DT
cord-006860-a3b8hyyr	4919	28	findings	finding	NNS
cord-006860-a3b8hyyr	4919	29	suggest	suggest	VBP
cord-006860-a3b8hyyr	4919	30	a	a	DT
cord-006860-a3b8hyyr	4919	31	role	role	NN
cord-006860-a3b8hyyr	4919	32	for	for	IN
cord-006860-a3b8hyyr	4919	33	UPA	UPA	NNP
cord-006860-a3b8hyyr	4919	34	in	in	IN
cord-006860-a3b8hyyr	4919	35	the	the	DT
cord-006860-a3b8hyyr	4919	36	progression	progression	NN
cord-006860-a3b8hyyr	4919	37	of	of	IN
cord-006860-a3b8hyyr	4919	38	the	the	DT
cord-006860-a3b8hyyr	4919	39	coronary	coronary	JJ
cord-006860-a3b8hyyr	4919	40	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	4919	41	.	.	.
cord-006860-a3b8hyyr	4920	1	Adenosine	adenosine	NN
cord-006860-a3b8hyyr	4920	2	produced	produce	VBN
cord-006860-a3b8hyyr	4920	3	by	by	IN
cord-006860-a3b8hyyr	4920	4	vascular	vascular	JJ
cord-006860-a3b8hyyr	4920	5	cells	cell	NNS
cord-006860-a3b8hyyr	4920	6	,	,	,
cord-006860-a3b8hyyr	4920	7	platelets	platelet	NNS
cord-006860-a3b8hyyr	4920	8	and	and	CC
cord-006860-a3b8hyyr	4920	9	other	other	JJ
cord-006860-a3b8hyyr	4920	10	tissues	tissue	NNS
cord-006860-a3b8hyyr	4920	11	has	have	VBZ
cord-006860-a3b8hyyr	4920	12	been	be	VBN
cord-006860-a3b8hyyr	4920	13	proposed	propose	VBN
cord-006860-a3b8hyyr	4920	14	to	to	TO
cord-006860-a3b8hyyr	4920	15	be	be	VB
cord-006860-a3b8hyyr	4920	16	a	a	DT
cord-006860-a3b8hyyr	4920	17	vasodilator	vasodilator	NN
cord-006860-a3b8hyyr	4920	18	,	,	,
cord-006860-a3b8hyyr	4920	19	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	4920	20	platelet	platelet	NN
cord-006860-a3b8hyyr	4920	21	aggregation	aggregation	NN
cord-006860-a3b8hyyr	4920	22	,	,	,
cord-006860-a3b8hyyr	4920	23	stimulates	stimulate	VBZ
cord-006860-a3b8hyyr	4920	24	proliferation	proliferation	NN
cord-006860-a3b8hyyr	4920	25	and	and	CC
cord-006860-a3b8hyyr	4920	26	migration	migration	NN
cord-006860-a3b8hyyr	4920	27	of	of	IN
cord-006860-a3b8hyyr	4920	28	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4920	29	cells	cell	NNS
cord-006860-a3b8hyyr	4920	30	as	as	RB
cord-006860-a3b8hyyr	4920	31	well	well	RB
cord-006860-a3b8hyyr	4920	32	as	as	IN
cord-006860-a3b8hyyr	4920	33	exhibits	exhibit	VBZ
cord-006860-a3b8hyyr	4920	34	antiinflammatory	antiinflammatory	JJ
cord-006860-a3b8hyyr	4920	35	effects	effect	NNS
cord-006860-a3b8hyyr	4920	36	.	.	.
cord-006860-a3b8hyyr	4921	1	Adenosine	adenosine	NN
cord-006860-a3b8hyyr	4921	2	of	of	IN
cord-006860-a3b8hyyr	4921	3	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4921	4	origin	origin	JJ
cord-006860-a3b8hyyr	4921	5	intra	intra	NN
cord-006860-a3b8hyyr	4921	6	-	-	:
cord-006860-a3b8hyyr	4921	7	and	and	CC
cord-006860-a3b8hyyr	4921	8	extracellularly	extracellularly	RB
cord-006860-a3b8hyyr	4921	9	formed	form	VBN
cord-006860-a3b8hyyr	4921	10	and	and	CC
cord-006860-a3b8hyyr	4921	11	highly	highly	RB
cord-006860-a3b8hyyr	4921	12	concentrated	concentrated	JJ
cord-006860-a3b8hyyr	4921	13	at	at	IN
cord-006860-a3b8hyyr	4921	14	the	the	DT
cord-006860-a3b8hyyr	4921	15	luminal	luminal	JJ
cord-006860-a3b8hyyr	4921	16	surface	surface	NN
cord-006860-a3b8hyyr	4921	17	may	may	MD
cord-006860-a3b8hyyr	4921	18	constitute	constitute	VB
cord-006860-a3b8hyyr	4921	19	an	an	DT
cord-006860-a3b8hyyr	4921	20	important	important	JJ
cord-006860-a3b8hyyr	4921	21	antiaggregatory	antiaggregatory	NN
cord-006860-a3b8hyyr	4921	22	mechanism	mechanism	NN
cord-006860-a3b8hyyr	4921	23	,	,	,
cord-006860-a3b8hyyr	4921	24	which	which	WDT
cord-006860-a3b8hyyr	4921	25	is	be	VBZ
cord-006860-a3b8hyyr	4921	26	part	part	NN
cord-006860-a3b8hyyr	4921	27	of	of	IN
cord-006860-a3b8hyyr	4921	28	the	the	DT
cord-006860-a3b8hyyr	4921	29	well	well	RB
cord-006860-a3b8hyyr	4921	30	-	-	HYPH
cord-006860-a3b8hyyr	4921	31	known	know	VBN
cord-006860-a3b8hyyr	4921	32	antithrombogenicity	antithrombogenicity	NN
cord-006860-a3b8hyyr	4921	33	of	of	IN
cord-006860-a3b8hyyr	4921	34	an	an	DT
cord-006860-a3b8hyyr	4921	35	intact	intact	JJ
cord-006860-a3b8hyyr	4921	36	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4921	37	lining	lining	NN
cord-006860-a3b8hyyr	4921	38	.	.	.
cord-006860-a3b8hyyr	4922	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	4922	2	was	be	VBD
cord-006860-a3b8hyyr	4922	3	the	the	DT
cord-006860-a3b8hyyr	4922	4	aim	aim	NN
cord-006860-a3b8hyyr	4922	5	of	of	IN
cord-006860-a3b8hyyr	4922	6	this	this	DT
cord-006860-a3b8hyyr	4922	7	study	study	NN
cord-006860-a3b8hyyr	4922	8	to	to	TO
cord-006860-a3b8hyyr	4922	9	investigate	investigate	VB
cord-006860-a3b8hyyr	4922	10	whether	whether	IN
cord-006860-a3b8hyyr	4922	11	adenosine	adenosine	NN
cord-006860-a3b8hyyr	4922	12	could	could	MD
cord-006860-a3b8hyyr	4922	13	influence	influence	VB
cord-006860-a3b8hyyr	4922	14	the	the	DT
cord-006860-a3b8hyyr	4922	15	fibfinolytic	fibfinolytic	JJ
cord-006860-a3b8hyyr	4922	16	potential	potential	NN
cord-006860-a3b8hyyr	4922	17	of	of	IN
cord-006860-a3b8hyyr	4922	18	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4922	19	cells	cell	NNS
cord-006860-a3b8hyyr	4922	20	.	.	.
cord-006860-a3b8hyyr	4923	1	When	when	WRB
cord-006860-a3b8hyyr	4923	2	confluent	confluent	JJ
cord-006860-a3b8hyyr	4923	3	human	human	JJ
cord-006860-a3b8hyyr	4923	4	umbilical	umbilical	JJ
cord-006860-a3b8hyyr	4923	5	vein	vein	NN
cord-006860-a3b8hyyr	4923	6	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4923	7	cells	cell	NNS
cord-006860-a3b8hyyr	4923	8	were	be	VBD
cord-006860-a3b8hyyr	4923	9	incubated	incubate	VBN
cord-006860-a3b8hyyr	4923	10	with	with	IN
cord-006860-a3b8hyyr	4923	11	adenosine	adenosine	NN
cord-006860-a3b8hyyr	4923	12	(	(	-LRB-
cord-006860-a3b8hyyr	4923	13	0.01	0.01	CD
cord-006860-a3b8hyyr	4923	14	-	-	SYM
cord-006860-a3b8hyyr	4923	15	10mM	10mm	CD
cord-006860-a3b8hyyr	4923	16	)	)	-RRB-
cord-006860-a3b8hyyr	4923	17	a	a	DT
cord-006860-a3b8hyyr	4923	18	significant	significant	JJ
cord-006860-a3b8hyyr	4923	19	dose	dose	NN
cord-006860-a3b8hyyr	4923	20	dependent	dependent	JJ
cord-006860-a3b8hyyr	4923	21	decrease	decrease	NN
cord-006860-a3b8hyyr	4923	22	in	in	IN
cord-006860-a3b8hyyr	4923	23	plasminogen	plasminogen	NN
cord-006860-a3b8hyyr	4923	24	activator	activator	NN
cord-006860-a3b8hyyr	4923	25	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4923	26	type-1	type-1	NN
cord-006860-a3b8hyyr	4924	1	(	(	-LRB-
cord-006860-a3b8hyyr	4924	2	PAI	PAI	NNP
cord-006860-a3b8hyyr	4924	3	-	-	HYPH
cord-006860-a3b8hyyr	4924	4	I	i	NN
cord-006860-a3b8hyyr	4924	5	)	)	-RRB-
cord-006860-a3b8hyyr	4924	6	antigen	antigen	NN
cord-006860-a3b8hyyr	4924	7	production	production	NN
cord-006860-a3b8hyyr	4924	8	by	by	IN
cord-006860-a3b8hyyr	4924	9	this	this	DT
cord-006860-a3b8hyyr	4924	10	cells	cell	NNS
cord-006860-a3b8hyyr	4924	11	was	be	VBD
cord-006860-a3b8hyyr	4924	12	seen	see	VBN
cord-006860-a3b8hyyr	4924	13	as	as	IN
cord-006860-a3b8hyyr	4924	14	compared	compare	VBN
cord-006860-a3b8hyyr	4924	15	to	to	IN
cord-006860-a3b8hyyr	4924	16	control	control	NN
cord-006860-a3b8hyyr	4924	17	.	.	.
cord-006860-a3b8hyyr	4925	1	This	this	DT
cord-006860-a3b8hyyr	4925	2	effect	effect	NN
cord-006860-a3b8hyyr	4925	3	by	by	IN
cord-006860-a3b8hyyr	4925	4	adenosine	adenosine	NN
cord-006860-a3b8hyyr	4925	5	was	be	VBD
cord-006860-a3b8hyyr	4925	6	also	also	RB
cord-006860-a3b8hyyr	4925	7	time	time	NN
cord-006860-a3b8hyyr	4925	8	dependent	dependent	JJ
cord-006860-a3b8hyyr	4925	9	and	and	CC
cord-006860-a3b8hyyr	4925	10	seen	see	VBN
cord-006860-a3b8hyyr	4925	11	after	after	IN
cord-006860-a3b8hyyr	4925	12	2	2	CD
cord-006860-a3b8hyyr	4925	13	hours	hour	NNS
cord-006860-a3b8hyyr	4925	14	of	of	IN
cord-006860-a3b8hyyr	4925	15	incubation	incubation	NN
cord-006860-a3b8hyyr	4925	16	with	with	IN
cord-006860-a3b8hyyr	4925	17	adenosine	adenosine	NN
cord-006860-a3b8hyyr	4925	18	.	.	.
cord-006860-a3b8hyyr	4926	1	As	as	IN
cord-006860-a3b8hyyr	4926	2	determined	determine	VBN
cord-006860-a3b8hyyr	4926	3	by	by	IN
cord-006860-a3b8hyyr	4926	4	ELISA	ELISA	NNP
cord-006860-a3b8hyyr	4926	5	,	,	,
cord-006860-a3b8hyyr	4926	6	PAI	PAI	NNP
cord-006860-a3b8hyyr	4926	7	-	-	HYPH
cord-006860-a3b8hyyr	4926	8	I	I	NNP
cord-006860-a3b8hyyr	4926	9	antigen	antigen	NN
cord-006860-a3b8hyyr	4926	10	in	in	IN
cord-006860-a3b8hyyr	4926	11	conditioned	conditioned	JJ
cord-006860-a3b8hyyr	4926	12	media	medium	NNS
cord-006860-a3b8hyyr	4926	13	of	of	IN
cord-006860-a3b8hyyr	4926	14	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4926	15	cells	cell	NNS
cord-006860-a3b8hyyr	4926	16	incubated	incubate	VBN
cord-006860-a3b8hyyr	4926	17	with	with	IN
cord-006860-a3b8hyyr	4926	18	10mM	10mm	CD
cord-006860-a3b8hyyr	4926	19	adenosine	adenosine	NN
cord-006860-a3b8hyyr	4926	20	decreased	decrease	VBD
cord-006860-a3b8hyyr	4926	21	to	to	IN
cord-006860-a3b8hyyr	4926	22	57	57	CD
cord-006860-a3b8hyyr	4926	23	%	%	NN
cord-006860-a3b8hyyr	4926	24	as	as	IN
cord-006860-a3b8hyyr	4926	25	compared	compare	VBN
cord-006860-a3b8hyyr	4926	26	to	to	IN
cord-006860-a3b8hyyr	4926	27	control	control	NN
cord-006860-a3b8hyyr	4926	28	.	.	.
cord-006860-a3b8hyyr	4927	1	PAI	PAI	NNP
cord-006860-a3b8hyyr	4927	2	-	-	HYPH
cord-006860-a3b8hyyr	4927	3	I	i	NN
cord-006860-a3b8hyyr	4927	4	antigen	antigen	NN
cord-006860-a3b8hyyr	4927	5	in	in	IN
cord-006860-a3b8hyyr	4927	6	extracelullar	extracelullar	JJ
cord-006860-a3b8hyyr	4927	7	matrix	matrix	NN
cord-006860-a3b8hyyr	4927	8	of	of	IN
cord-006860-a3b8hyyr	4927	9	these	these	DT
cord-006860-a3b8hyyr	4927	10	cells	cell	NNS
cord-006860-a3b8hyyr	4927	11	was	be	VBD
cord-006860-a3b8hyyr	4927	12	also	also	RB
cord-006860-a3b8hyyr	4927	13	reduced	reduce	VBN
cord-006860-a3b8hyyr	4927	14	by	by	IN
cord-006860-a3b8hyyr	4927	15	incubation	incubation	NN
cord-006860-a3b8hyyr	4927	16	with	with	IN
cord-006860-a3b8hyyr	4927	17	adenosine	adenosine	NN
cord-006860-a3b8hyyr	4927	18	.	.	.
cord-006860-a3b8hyyr	4928	1	These	these	DT
cord-006860-a3b8hyyr	4928	2	results	result	NNS
cord-006860-a3b8hyyr	4928	3	were	be	VBD
cord-006860-a3b8hyyr	4928	4	also	also	RB
cord-006860-a3b8hyyr	4928	5	reflected	reflect	VBN
cord-006860-a3b8hyyr	4928	6	on	on	IN
cord-006860-a3b8hyyr	4928	7	the	the	DT
cord-006860-a3b8hyyr	4928	8	level	level	NN
cord-006860-a3b8hyyr	4928	9	of	of	IN
cord-006860-a3b8hyyr	4928	10	specific	specific	JJ
cord-006860-a3b8hyyr	4928	11	mRNA	mrna	NN
cord-006860-a3b8hyyr	4928	12	as	as	IN
cord-006860-a3b8hyyr	4928	13	determined	determine	VBN
cord-006860-a3b8hyyr	4928	14	by	by	IN
cord-006860-a3b8hyyr	4928	15	Northern	northern	JJ
cord-006860-a3b8hyyr	4928	16	blotting	blotting	NN
cord-006860-a3b8hyyr	4928	17	.	.	.
cord-006860-a3b8hyyr	4929	1	PAI	PAI	NNP
cord-006860-a3b8hyyr	4929	2	-	-	HYPH
cord-006860-a3b8hyyr	4929	3	I	I	NNP
cord-006860-a3b8hyyr	4929	4	mRNA	mrna	NN
cord-006860-a3b8hyyr	4929	5	decreased	decrease	VBD
cord-006860-a3b8hyyr	4929	6	in	in	IN
cord-006860-a3b8hyyr	4929	7	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4929	8	cells	cell	NNS
cord-006860-a3b8hyyr	4929	9	after	after	IN
cord-006860-a3b8hyyr	4929	10	incubation	incubation	NN
cord-006860-a3b8hyyr	4929	11	for	for	IN
cord-006860-a3b8hyyr	4929	12	4	4	CD
cord-006860-a3b8hyyr	4929	13	hours	hour	NNS
cord-006860-a3b8hyyr	4929	14	with	with	IN
cord-006860-a3b8hyyr	4929	15	adenosine	adenosine	NN
cord-006860-a3b8hyyr	4929	16	(	(	-LRB-
cord-006860-a3b8hyyr	4929	17	10mM	10mm	CD
cord-006860-a3b8hyyr	4929	18	)	)	-RRB-
cord-006860-a3b8hyyr	4929	19	to	to	IN
cord-006860-a3b8hyyr	4929	20	77	77	CD
cord-006860-a3b8hyyr	4929	21	%	%	NN
cord-006860-a3b8hyyr	4929	22	(	(	-LRB-
cord-006860-a3b8hyyr	4929	23	2.2Kb	2.2kb	CD
cord-006860-a3b8hyyr	4929	24	)	)	-RRB-
cord-006860-a3b8hyyr	4929	25	and	and	CC
cord-006860-a3b8hyyr	4929	26	85	85	CD
cord-006860-a3b8hyyr	4929	27	%	%	NN
cord-006860-a3b8hyyr	4929	28	(	(	-LRB-
cord-006860-a3b8hyyr	4929	29	3.2Kb	3.2kb	CD
cord-006860-a3b8hyyr	4929	30	)	)	-RRB-
cord-006860-a3b8hyyr	4929	31	of	of	IN
cord-006860-a3b8hyyr	4929	32	control	control	NN
cord-006860-a3b8hyyr	4929	33	.	.	.
cord-006860-a3b8hyyr	4930	1	In	in	IN
cord-006860-a3b8hyyr	4930	2	conclusion	conclusion	NN
cord-006860-a3b8hyyr	4930	3	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4930	4	data	datum	NNS
cord-006860-a3b8hyyr	4930	5	demonstrate	demonstrate	VBP
cord-006860-a3b8hyyr	4930	6	that	that	IN
cord-006860-a3b8hyyr	4930	7	adenosine	adenosine	NN
cord-006860-a3b8hyyr	4930	8	can	can	MD
cord-006860-a3b8hyyr	4930	9	downregulate	downregulate	VB
cord-006860-a3b8hyyr	4930	10	the	the	DT
cord-006860-a3b8hyyr	4930	11	expression	expression	NN
cord-006860-a3b8hyyr	4930	12	of	of	IN
cord-006860-a3b8hyyr	4930	13	PAI-1	PAI-1	NNP
cord-006860-a3b8hyyr	4930	14	in	in	IN
cord-006860-a3b8hyyr	4930	15	cultured	cultured	JJ
cord-006860-a3b8hyyr	4930	16	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4930	17	cells	cell	NNS
cord-006860-a3b8hyyr	4930	18	thereby	thereby	RB
cord-006860-a3b8hyyr	4930	19	increasing	increase	VBG
cord-006860-a3b8hyyr	4930	20	the	the	DT
cord-006860-a3b8hyyr	4930	21	profibrinolytic	profibrinolytic	JJ
cord-006860-a3b8hyyr	4930	22	capacity	capacity	NN
cord-006860-a3b8hyyr	4930	23	of	of	IN
cord-006860-a3b8hyyr	4930	24	these	these	DT
cord-006860-a3b8hyyr	4930	25	cells	cell	NNS
cord-006860-a3b8hyyr	4930	26	.	.	.
cord-006860-a3b8hyyr	4931	1	This	this	DT
cord-006860-a3b8hyyr	4931	2	effect	effect	NN
cord-006860-a3b8hyyr	4931	3	of	of	IN
cord-006860-a3b8hyyr	4931	4	adenosine	adenosine	NN
cord-006860-a3b8hyyr	4931	5	might	may	MD
cord-006860-a3b8hyyr	4931	6	contribute	contribute	VB
cord-006860-a3b8hyyr	4931	7	to	to	IN
cord-006860-a3b8hyyr	4931	8	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4931	9	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	4931	10	potential	potential	NN
cord-006860-a3b8hyyr	4931	11	in	in	IN
cord-006860-a3b8hyyr	4931	12	addtion	addtion	NN
cord-006860-a3b8hyyr	4931	13	to	to	IN
cord-006860-a3b8hyyr	4931	14	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4931	15	known	know	VBN
cord-006860-a3b8hyyr	4931	16	antiaggregatory	antiaggregatory	NN
cord-006860-a3b8hyyr	4931	17	effect	effect	NN
cord-006860-a3b8hyyr	4931	18	.	.	.
cord-006860-a3b8hyyr	4932	1	Sowohl	Sowohl	NNP
cord-006860-a3b8hyyr	4932	2	die	die	VBP
cord-006860-a3b8hyyr	4932	3	Effizienz	Effizienz	NNP
cord-006860-a3b8hyyr	4932	4	als	als	CD
cord-006860-a3b8hyyr	4932	5	such	such	JJ
cord-006860-a3b8hyyr	4932	6	die	die	NN
cord-006860-a3b8hyyr	4933	1	Komplikationen	Komplikationen	NNP
cord-006860-a3b8hyyr	4933	2	einer	einer	NNP
cord-006860-a3b8hyyr	4933	3	Antikoagulantien	Antikoagulantien	NNP
cord-006860-a3b8hyyr	4933	4	-	-	HYPH
cord-006860-a3b8hyyr	4933	5	Dauerbehandlung	Dauerbehandlung	NNP
cord-006860-a3b8hyyr	4933	6	sind	sind	NNPS
cord-006860-a3b8hyyr	4933	7	in	in	IN
cord-006860-a3b8hyyr	4933	8	erster	erster	NNP
cord-006860-a3b8hyyr	4933	9	Linie	Linie	NNP
cord-006860-a3b8hyyr	4933	10	yon	yon	NNP
cord-006860-a3b8hyyr	4933	11	der	der	NNP
cord-006860-a3b8hyyr	4933	12	Gore	Gore	NNP
cord-006860-a3b8hyyr	4933	13	und	und	IN
cord-006860-a3b8hyyr	4934	1	Engmaschigkeit	Engmaschigkeit	NNP
cord-006860-a3b8hyyr	4934	2	der	der	NNP
cord-006860-a3b8hyyr	4934	3	Gednnungskontrellen	Gednnungskontrellen	NNP
cord-006860-a3b8hyyr	4934	4	abh	abh	NN
cord-006860-a3b8hyyr	4934	5	~	~	NFP
cord-006860-a3b8hyyr	4934	6	ngig	ngig	NNP
cord-006860-a3b8hyyr	4934	7	Seit	Seit	NNP
cord-006860-a3b8hyyr	4934	8	1986	1986	CD
cord-006860-a3b8hyyr	4934	9	wird	wird	NNP
cord-006860-a3b8hyyr	4934	10	die	die	VBP
cord-006860-a3b8hyyr	4934	11	Schulung	Schulung	NNP
cord-006860-a3b8hyyr	4934	12	zur	zur	NNP
cord-006860-a3b8hyyr	4934	13	Gerinnungs	Gerinnungs	NNP
cord-006860-a3b8hyyr	4934	14	-	-	HYPH
cord-006860-a3b8hyyr	4934	15	Selbstkontrolte	Selbstkontrolte	NNP
cord-006860-a3b8hyyr	4934	16	in	in	IN
cord-006860-a3b8hyyr	4934	17	der	der	NNP
cord-006860-a3b8hyyr	4934	18	Herz	Herz	NNP
cord-006860-a3b8hyyr	4934	19	-	-	HYPH
cord-006860-a3b8hyyr	4934	20	Kreistauf	Kreistauf	NNP
cord-006860-a3b8hyyr	4934	21	-	-	HYPH
cord-006860-a3b8hyyr	4934	22	Klinik	Klinik	NNP
cord-006860-a3b8hyyr	4934	23	Bad	Bad	NNP
cord-006860-a3b8hyyr	4934	24	Bedebarg	Bedebarg	NNP
cord-006860-a3b8hyyr	4934	25	in	in	IN
cord-006860-a3b8hyyr	4934	26	Gruppen	Gruppen	NNP
cord-006860-a3b8hyyr	4934	27	eingeObt	eingeObt	NNP
cord-006860-a3b8hyyr	4934	28	.	.	.
cord-006860-a3b8hyyr	4935	1	Die	die	VB
cord-006860-a3b8hyyr	4935	2	theoretische	theoretische	NN
cord-006860-a3b8hyyr	4935	3	und	und	IN
cord-006860-a3b8hyyr	4935	4	praktische	praktische	NNP
cord-006860-a3b8hyyr	4935	5	Anleitung	Anleitung	NNP
cord-006860-a3b8hyyr	4935	6	erfolgt	erfolgt	VBP
cord-006860-a3b8hyyr	4935	7	in	in	IN
cord-006860-a3b8hyyr	4935	8	8	8	CD
cord-006860-a3b8hyyr	4935	9	Stunden	Stunden	NNP
cord-006860-a3b8hyyr	4935	10	durch	durch	NNP
cord-006860-a3b8hyyr	4935	11	eine	eine	NNP
cord-006860-a3b8hyyr	4935	12	in	in	IN
cord-006860-a3b8hyyr	4935	13	der	der	NNP
cord-006860-a3b8hyyr	4935	14	Patientenschuiung	Patientenschuiung	NNP
cord-006860-a3b8hyyr	4935	15	erfahrene	erfahrene	NN
cord-006860-a3b8hyyr	4936	1	Arzthelfedn	Arzthelfedn	NNP
cord-006860-a3b8hyyr	4937	1	(	(	-LRB-
cord-006860-a3b8hyyr	4937	2	oder	oder	NNP
cord-006860-a3b8hyyr	4937	3	Krankenschwested	Krankenschwested	NNP
cord-006860-a3b8hyyr	4937	4	-	-	HYPH
cord-006860-a3b8hyyr	4937	5	pfleger	pfleger	NNP
cord-006860-a3b8hyyr	4937	6	)	)	-RRB-
cord-006860-a3b8hyyr	4937	7	und	und	CC
cord-006860-a3b8hyyr	4937	8	einen	einen	NNP
cord-006860-a3b8hyyr	4937	9	Arzt	Arzt	NNP
cord-006860-a3b8hyyr	4937	10	.	.	.
cord-006860-a3b8hyyr	4938	1	Die	die	VB
cord-006860-a3b8hyyr	4938	2	praktische	praktische	NNP
cord-006860-a3b8hyyr	4938	3	Schulung	Schulung	NNP
cord-006860-a3b8hyyr	4938	4	wird	wird	NNP
cord-006860-a3b8hyyr	4939	1	durch	durch	NNP
cord-006860-a3b8hyyr	4939	2	einen	einen	NNP
cord-006860-a3b8hyyr	4939	3	patientennahen	patientennahen	NNP
cord-006860-a3b8hyyr	4939	4	theoretischen	theoretischen	NNP
cord-006860-a3b8hyyr	4939	5	Tell	tell	VB
cord-006860-a3b8hyyr	4939	6	erg	erg	NNP
cord-006860-a3b8hyyr	4939	7	~	~	NNP
cord-006860-a3b8hyyr	4939	8	nzt	nzt	NNP
cord-006860-a3b8hyyr	4939	9	.	.	.
cord-006860-a3b8hyyr	4940	1	Verglichen	Verglichen	NNP
cord-006860-a3b8hyyr	4940	2	mit	mit	NNP
cord-006860-a3b8hyyr	4940	3	konventionell	konventionell	NNP
cord-006860-a3b8hyyr	4941	1	~berwachten	~berwachten	NNP
cord-006860-a3b8hyyr	4942	1	oral	oral	NNP
cord-006860-a3b8hyyr	4942	2	antikoagulierten	antikoagulierten	NNP
cord-006860-a3b8hyyr	4942	3	Patienten	Patienten	NNP
cord-006860-a3b8hyyr	4942	4	(	(	-LRB-
cord-006860-a3b8hyyr	4942	5	ca	ca	NN
cord-006860-a3b8hyyr	4942	6	.	.	.
cord-006860-a3b8hyyr	4943	1	50	50	CD
cord-006860-a3b8hyyr	4943	2	%	%	NN
cord-006860-a3b8hyyr	4944	1	der	der	NNP
cord-006860-a3b8hyyr	4944	2	TPZ	TPZ	NNP
cord-006860-a3b8hyyr	4944	3	-	-	HYPH
cord-006860-a3b8hyyr	4944	4	Werte	Werte	NNP
cord-006860-a3b8hyyr	4944	5	liegen	liegen	XX
cord-006860-a3b8hyyr	4945	1	i	-PRON-	PRP
cord-006860-a3b8hyyr	4945	2	m	be	VBP
cord-006860-a3b8hyyr	4945	3	theapeutischen	theapeutischen	NNP
cord-006860-a3b8hyyr	4945	4	Bereich	Bereich	NNP
cord-006860-a3b8hyyr	4945	5	)	)	-RRB-
cord-006860-a3b8hyyr	4945	6	erreichten	erreichten	NNP
cord-006860-a3b8hyyr	4945	7	216	216	CD
cord-006860-a3b8hyyr	4945	8	Quickwert	Quickwert	NNP
cord-006860-a3b8hyyr	4945	9	-	-	HYPH
cord-006860-a3b8hyyr	4945	10	Selbstbestimmer	Selbstbestimmer	NNP
cord-006860-a3b8hyyr	4945	11	,	,	,
cord-006860-a3b8hyyr	4945	12	daf$	daf$	NNP
cord-006860-a3b8hyyr	4945	13	83,1	83,1	CD
cord-006860-a3b8hyyr	4945	14	%	%	NN
cord-006860-a3b8hyyr	4945	15	yon	yon	NNP
cord-006860-a3b8hyyr	4945	16	14	14	CD
cord-006860-a3b8hyyr	4945	17	812	812	CD
cord-006860-a3b8hyyr	4945	18	TPZ	TPZ	NNP
cord-006860-a3b8hyyr	4945	19	-	-	HYPH
cord-006860-a3b8hyyr	4945	20	Werten	Werten	NNP
cord-006860-a3b8hyyr	4946	1	i	-PRON-	PRP
cord-006860-a3b8hyyr	4946	2	m	be	VBP
cord-006860-a3b8hyyr	4946	3	therapeutischen	therapeutischen	NNP
cord-006860-a3b8hyyr	4946	4	Bereich	Bereich	NNP
cord-006860-a3b8hyyr	4946	5	lagen	lagen	NNP
cord-006860-a3b8hyyr	4946	6	(	(	-LRB-
cord-006860-a3b8hyyr	4946	7	Tabelle	Tabelle	NNP
cord-006860-a3b8hyyr	4946	8	1	1	CD
cord-006860-a3b8hyyr	4946	9	)	)	-RRB-
cord-006860-a3b8hyyr	4946	10	.	.	.
cord-006860-a3b8hyyr	4947	1	Schwerwiegende	Schwerwiegende	NNP
cord-006860-a3b8hyyr	4947	2	thromboernbolische	thromboernbolische	NNP
cord-006860-a3b8hyyr	4947	3	Ereignisse	Ereignisse	NNP
cord-006860-a3b8hyyr	4947	4	oder	oder	NN
cord-006860-a3b8hyyr	4947	5	Blutungskomplikatienen	Blutungskomplikatienen	NNP
cord-006860-a3b8hyyr	4947	6	wurden	wurden	VBD
cord-006860-a3b8hyyr	4947	7	nicht	nicht	NNP
cord-006860-a3b8hyyr	4947	8	beobachtet	beobachtet	NNP
cord-006860-a3b8hyyr	4947	9	.	.	.
cord-006860-a3b8hyyr	4948	1	Durchschnittlich	Durchschnittlich	NNP
cord-006860-a3b8hyyr	4948	2	kontrolliert	kontrolliert	NN
cord-006860-a3b8hyyr	4948	3	der	der	NNP
cord-006860-a3b8hyyr	4948	4	Quickwert	Quickwert	NNP
cord-006860-a3b8hyyr	4948	5	-	-	HYPH
cord-006860-a3b8hyyr	4948	6	Selbstbestimmer	Selbstbestimmer	NNP
cord-006860-a3b8hyyr	4948	7	seine	seine	NNP
cord-006860-a3b8hyyr	4948	8	Gerineungswerte	Gerineungswerte	NNP
cord-006860-a3b8hyyr	4948	9	w6chentlich	w6chentlich	NNP
cord-006860-a3b8hyyr	4948	10	,	,	,
cord-006860-a3b8hyyr	4948	11	Itmgstens	Itmgstens	NNP
cord-006860-a3b8hyyr	4948	12	i	-PRON-	PRP
cord-006860-a3b8hyyr	4948	13	m	be	VBP
cord-006860-a3b8hyyr	4948	14	Zweiwochen	Zweiwochen	NNP
cord-006860-a3b8hyyr	4948	15	-	-	HYPH
cord-006860-a3b8hyyr	4948	16	Abstand	Abstand	NNP
cord-006860-a3b8hyyr	4948	17	.	.	.
cord-006860-a3b8hyyr	4949	1	Ob	Ob	NNP
cord-006860-a3b8hyyr	4949	2	sich	sich	NNP
cord-006860-a3b8hyyr	4949	3	Blutungs	Blutungs	NNP
cord-006860-a3b8hyyr	4949	4	-	-	HYPH
cord-006860-a3b8hyyr	4949	5	und	und	NNP
cord-006860-a3b8hyyr	4949	6	Thremboembolierisiko	Thremboembolierisiko	NNP
cord-006860-a3b8hyyr	4949	7	langfristig	langfristig	NNP
cord-006860-a3b8hyyr	4949	8	senken	senken	NNP
cord-006860-a3b8hyyr	4949	9	lassen	lassen	NNP
cord-006860-a3b8hyyr	4949	10	bei	bei	NNP
cord-006860-a3b8hyyr	4949	11	gleichze~	gleichze~	NNP
cord-006860-a3b8hyyr	4950	1	iger	iger	NNP
cord-006860-a3b8hyyr	4950	2	Verbesserung	Verbesserung	NNP
cord-006860-a3b8hyyr	4950	3	yon	yon	NNP
cord-006860-a3b8hyyr	4950	4	Prognose	Prognose	NNP
cord-006860-a3b8hyyr	4950	5	und	und	RB
cord-006860-a3b8hyyr	4951	1	Lebensqualit	Lebensqualit	NNP
cord-006860-a3b8hyyr	4952	1	~it	~it	NNP
cord-006860-a3b8hyyr	4952	2	,	,	,
cord-006860-a3b8hyyr	4952	3	bedarf	bedarf	NNP
cord-006860-a3b8hyyr	4952	4	des	des	NNP
cord-006860-a3b8hyyr	4952	5	Nachweises	Nachweises	NNP
cord-006860-a3b8hyyr	4952	6	i	-PRON-	PRP
cord-006860-a3b8hyyr	4952	7	m	be	VBP
cord-006860-a3b8hyyr	4952	8	Rahmen	Rahmen	NNP
cord-006860-a3b8hyyr	4952	9	einer	einer	NNP
cord-006860-a3b8hyyr	4952	10	randomisierten	randomisierten	NNP
cord-006860-a3b8hyyr	4952	11	,	,	,
cord-006860-a3b8hyyr	4952	12	kontrollierten	kontrollierten	NNP
cord-006860-a3b8hyyr	4952	13	und	und	NNP
cord-006860-a3b8hyyr	4952	14	prospektiven	prospektiven	NNP
cord-006860-a3b8hyyr	4952	15	Studie	Studie	NNP
cord-006860-a3b8hyyr	4952	16	.	.	.
cord-006860-a3b8hyyr	4953	1	Tabelle	Tabelle	NNP
cord-006860-a3b8hyyr	4954	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	4955	1	Verteilun	Verteilun	NNP
cord-006860-a3b8hyyr	4956	1	~l	~l	NNP
cord-006860-a3b8hyyr	4956	2	der	der	NNP
cord-006860-a3b8hyyr	4956	3	selbstbestimrnten	selbstbestimrnten	NNP
cord-006860-a3b8hyyr	4957	1	Gednnur	Gednnur	NNP
cord-006860-a3b8hyyr	4958	1	~swerte	~swerte	XX
cord-006860-a3b8hyyr	4959	1	Zeitraum	Zeitraum	NNP
cord-006860-a3b8hyyr	4960	1	1986	1986	CD
cord-006860-a3b8hyyr	4960	2	Zeitraum	Zeitraum	NNP
cord-006860-a3b8hyyr	4960	3	-1988	-1988	HYPH
cord-006860-a3b8hyyr	4960	4	Zeitraum	Zeitraum	NNP
cord-006860-a3b8hyyr	4961	1	1986	1986	CD
cord-006860-a3b8hyyr	4961	2	Zeitraum	Zeitraum	NNP
cord-006860-a3b8hyyr	4961	3	-1990	-1990	HYPH
cord-006860-a3b8hyyr	4961	4	Zeitraum	Zeitraum	NNP
cord-006860-a3b8hyyr	4961	5	1986	1986	CD
cord-006860-a3b8hyyr	4961	6	Zeitraum	Zeitraum	NNP
cord-006860-a3b8hyyr	4961	7	-1992	-1992	VBD
cord-006860-a3b8hyyr	4962	1	To	to	TO
cord-006860-a3b8hyyr	4962	2	evaluate	evaluate	VB
cord-006860-a3b8hyyr	4962	3	the	the	DT
cord-006860-a3b8hyyr	4962	4	potential	potential	JJ
cord-006860-a3b8hyyr	4962	5	benefit	benefit	NN
cord-006860-a3b8hyyr	4962	6	of	of	IN
cord-006860-a3b8hyyr	4962	7	an	an	DT
cord-006860-a3b8hyyr	4962	8	optimized	optimized	JJ
cord-006860-a3b8hyyr	4962	9	oral	oral	JJ
cord-006860-a3b8hyyr	4962	10	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	4962	11	management	management	NN
cord-006860-a3b8hyyr	4962	12	with	with	IN
cord-006860-a3b8hyyr	4962	13	INR	INR	NNP
cord-006860-a3b8hyyr	4962	14	measurements	measurement	NNS
cord-006860-a3b8hyyr	4962	15	performed	perform	VBN
cord-006860-a3b8hyyr	4962	16	by	by	IN
cord-006860-a3b8hyyr	4962	17	the	the	DT
cord-006860-a3b8hyyr	4962	18	patients	patient	NNS
cord-006860-a3b8hyyr	4962	19	themselves	-PRON-	PRP
cord-006860-a3b8hyyr	4962	20	,	,	,
cord-006860-a3b8hyyr	4962	21	two	two	CD
cord-006860-a3b8hyyr	4962	22	prospective	prospective	JJ
cord-006860-a3b8hyyr	4962	23	randomized	randomized	JJ
cord-006860-a3b8hyyr	4962	24	studies	study	NNS
cord-006860-a3b8hyyr	4962	25	have	have	VBP
cord-006860-a3b8hyyr	4962	26	been	be	VBN
cord-006860-a3b8hyyr	4962	27	completed	complete	VBN
cord-006860-a3b8hyyr	4962	28	.	.	.
cord-006860-a3b8hyyr	4963	1	The	the	DT
cord-006860-a3b8hyyr	4963	2	first	first	JJ
cord-006860-a3b8hyyr	4963	3	study	study	NN
cord-006860-a3b8hyyr	4963	4	(	(	-LRB-
cord-006860-a3b8hyyr	4963	5	n=60	n=60	RB
cord-006860-a3b8hyyr	4963	6	)	)	-RRB-
cord-006860-a3b8hyyr	4963	7	was	be	VBD
cord-006860-a3b8hyyr	4963	8	performed	perform	VBN
cord-006860-a3b8hyyr	4963	9	to	to	TO
cord-006860-a3b8hyyr	4963	10	evaluate	evaluate	VB
cord-006860-a3b8hyyr	4963	11	the	the	DT
cord-006860-a3b8hyyr	4963	12	accuracy	accuracy	NN
cord-006860-a3b8hyyr	4963	13	of	of	IN
cord-006860-a3b8hyyr	4963	14	INR	INR	NNP
cord-006860-a3b8hyyr	4963	15	self	self	NN
cord-006860-a3b8hyyr	4963	16	-	-	HYPH
cord-006860-a3b8hyyr	4963	17	testing	testing	NN
cord-006860-a3b8hyyr	4963	18	(	(	-LRB-
cord-006860-a3b8hyyr	4963	19	INR	INR	NNP
cord-006860-a3b8hyyr	4963	20	-	-	HYPH
cord-006860-a3b8hyyr	4963	21	ST	ST	NNP
cord-006860-a3b8hyyr	4963	22	)	)	-RRB-
cord-006860-a3b8hyyr	4963	23	compared	compare	VBN
cord-006860-a3b8hyyr	4963	24	with	with	IN
cord-006860-a3b8hyyr	4963	25	standard	standard	JJ
cord-006860-a3b8hyyr	4963	26	laboratory	laboratory	NN
cord-006860-a3b8hyyr	4963	27	controls	control	NNS
cord-006860-a3b8hyyr	4963	28	as	as	RB
cord-006860-a3b8hyyr	4963	29	well	well	RB
cord-006860-a3b8hyyr	4963	30	as	as	IN
cord-006860-a3b8hyyr	4963	31	the	the	DT
cord-006860-a3b8hyyr	4963	32	improvement	improvement	NN
cord-006860-a3b8hyyr	4963	33	of	of	IN
cord-006860-a3b8hyyr	4963	34	anticoagutation	anticoagutation	NN
cord-006860-a3b8hyyr	4963	35	monitoring	monitoring	NN
cord-006860-a3b8hyyr	4963	36	by	by	IN
cord-006860-a3b8hyyr	4963	37	INR	INR	NNP
cord-006860-a3b8hyyr	4963	38	-	-	HYPH
cord-006860-a3b8hyyr	4963	39	ST	ST	NNP
cord-006860-a3b8hyyr	4963	40	,	,	,
cord-006860-a3b8hyyr	4964	1	e.g.	e.g.	RB
cord-006860-a3b8hyyr	4964	2	the	the	DT
cord-006860-a3b8hyyr	4964	3	percentage	percentage	NN
cord-006860-a3b8hyyr	4964	4	of	of	IN
cord-006860-a3b8hyyr	4964	5	measurements	measurement	NNS
cord-006860-a3b8hyyr	4964	6	found	find	VBN
cord-006860-a3b8hyyr	4964	7	inside	inside	IN
cord-006860-a3b8hyyr	4964	8	the	the	DT
cord-006860-a3b8hyyr	4964	9	target	target	NN
cord-006860-a3b8hyyr	4964	10	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	4964	11	INR	INR	NNP
cord-006860-a3b8hyyr	4964	12	-	-	HYPH
cord-006860-a3b8hyyr	4964	13	range	range	NN
cord-006860-a3b8hyyr	4964	14	.	.	.
cord-006860-a3b8hyyr	4965	1	The	the	DT
cord-006860-a3b8hyyr	4965	2	231	231	CD
cord-006860-a3b8hyyr	4965	3	parallel	parallel	JJ
cord-006860-a3b8hyyr	4965	4	measurements	measurement	NNS
cord-006860-a3b8hyyr	4965	5	revealed	reveal	VBD
cord-006860-a3b8hyyr	4965	6	a	a	DT
cord-006860-a3b8hyyr	4965	7	high	high	JJ
cord-006860-a3b8hyyr	4965	8	accuracy	accuracy	NN
cord-006860-a3b8hyyr	4965	9	of	of	IN
cord-006860-a3b8hyyr	4965	10	INR	INR	NNP
cord-006860-a3b8hyyr	4965	11	-	-	HYPH
cord-006860-a3b8hyyr	4965	12	ST	ST	NNP
cord-006860-a3b8hyyr	4965	13	with	with	IN
cord-006860-a3b8hyyr	4965	14	a	a	DT
cord-006860-a3b8hyyr	4965	15	4.5	4.5	CD
cord-006860-a3b8hyyr	4965	16	%	%	NN
cord-006860-a3b8hyyr	4965	17	median	median	JJ
cord-006860-a3b8hyyr	4965	18	difference	difference	NN
cord-006860-a3b8hyyr	4965	19	between	between	IN
cord-006860-a3b8hyyr	4965	20	parallel	parallel	JJ
cord-006860-a3b8hyyr	4965	21	controls	control	NNS
cord-006860-a3b8hyyr	4965	22	of	of	IN
cord-006860-a3b8hyyr	4965	23	single	single	JJ
cord-006860-a3b8hyyr	4965	24	measurements	measurement	NNS
cord-006860-a3b8hyyr	4965	25	.	.	.
cord-006860-a3b8hyyr	4966	1	In	in	IN
cord-006860-a3b8hyyr	4966	2	addition	addition	NN
cord-006860-a3b8hyyr	4966	3	,	,	,
cord-006860-a3b8hyyr	4966	4	INR	INR	NNP
cord-006860-a3b8hyyr	4966	5	-	-	HYPH
cord-006860-a3b8hyyr	4966	6	ST	ST	NNP
cord-006860-a3b8hyyr	4966	7	resulted	result	VBD
cord-006860-a3b8hyyr	4966	8	in	in	IN
cord-006860-a3b8hyyr	4966	9	a	a	DT
cord-006860-a3b8hyyr	4966	10	significant	significant	JJ
cord-006860-a3b8hyyr	4966	11	increase	increase	NN
cord-006860-a3b8hyyr	4966	12	of	of	IN
cord-006860-a3b8hyyr	4966	13	measurements	measurement	NNS
cord-006860-a3b8hyyr	4966	14	inside	inside	IN
cord-006860-a3b8hyyr	4966	15	the	the	DT
cord-006860-a3b8hyyr	4966	16	target	target	NN
cord-006860-a3b8hyyr	4966	17	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	4966	18	range	range	NN
cord-006860-a3b8hyyr	4966	19	(	(	-LRB-
cord-006860-a3b8hyyr	4966	20	from	from	IN
cord-006860-a3b8hyyr	4966	21	54	54	CD
cord-006860-a3b8hyyr	4966	22	to	to	TO
cord-006860-a3b8hyyr	4966	23	80	80	CD
cord-006860-a3b8hyyr	4966	24	%	%	NN
cord-006860-a3b8hyyr	4966	25	)	)	-RRB-
cord-006860-a3b8hyyr	4966	26	in	in	IN
cord-006860-a3b8hyyr	4966	27	the	the	DT
cord-006860-a3b8hyyr	4966	28	entire	entire	JJ
cord-006860-a3b8hyyr	4966	29	group	group	NN
cord-006860-a3b8hyyr	4966	30	.	.	.
cord-006860-a3b8hyyr	4967	1	However	however	RB
cord-006860-a3b8hyyr	4967	2	,	,	,
cord-006860-a3b8hyyr	4967	3	INR	INR	NNP
cord-006860-a3b8hyyr	4967	4	-	-	HYPH
cord-006860-a3b8hyyr	4967	5	ST	ST	NNP
cord-006860-a3b8hyyr	4967	6	performed	perform	VBD
cord-006860-a3b8hyyr	4967	7	every	every	DT
cord-006860-a3b8hyyr	4967	8	4	4	CD
cord-006860-a3b8hyyr	4967	9	weeks	week	NNS
cord-006860-a3b8hyyr	4967	10	did	do	VBD
cord-006860-a3b8hyyr	4967	11	not	not	RB
cord-006860-a3b8hyyr	4967	12	result	result	VB
cord-006860-a3b8hyyr	4967	13	in	in	IN
cord-006860-a3b8hyyr	4967	14	a	a	DT
cord-006860-a3b8hyyr	4967	15	significant	significant	JJ
cord-006860-a3b8hyyr	4967	16	improvement	improvement	NN
cord-006860-a3b8hyyr	4967	17	,	,	,
cord-006860-a3b8hyyr	4967	18	while	while	IN
cord-006860-a3b8hyyr	4967	19	selfcontrols	selfcontrol	NNS
cord-006860-a3b8hyyr	4967	20	every	every	DT
cord-006860-a3b8hyyr	4967	21	week	week	NN
cord-006860-a3b8hyyr	4967	22	(	(	-LRB-
cord-006860-a3b8hyyr	4967	23	from	from	IN
cord-006860-a3b8hyyr	4967	24	44	44	CD
cord-006860-a3b8hyyr	4967	25	to	to	TO
cord-006860-a3b8hyyr	4967	26	84	84	CD
cord-006860-a3b8hyyr	4967	27	%	%	NN
cord-006860-a3b8hyyr	4967	28	)	)	-RRB-
cord-006860-a3b8hyyr	4967	29	and	and	CC
cord-006860-a3b8hyyr	4967	30	every	every	DT
cord-006860-a3b8hyyr	4967	31	2	2	CD
cord-006860-a3b8hyyr	4967	32	days	day	NNS
cord-006860-a3b8hyyr	4967	33	(	(	-LRB-
cord-006860-a3b8hyyr	4967	34	from	from	IN
cord-006860-a3b8hyyr	4967	35	51	51	CD
cord-006860-a3b8hyyr	4967	36	to	to	TO
cord-006860-a3b8hyyr	4967	37	84	84	CD
cord-006860-a3b8hyyr	4967	38	%	%	NN
cord-006860-a3b8hyyr	4967	39	)	)	-RRB-
cord-006860-a3b8hyyr	4967	40	did	do	VBD
cord-006860-a3b8hyyr	4967	41	.	.	.
cord-006860-a3b8hyyr	4968	1	In	in	IN
cord-006860-a3b8hyyr	4968	2	a	a	DT
cord-006860-a3b8hyyr	4968	3	second	second	JJ
cord-006860-a3b8hyyr	4968	4	study	study	NN
cord-006860-a3b8hyyr	4968	5	(	(	-LRB-
cord-006860-a3b8hyyr	4968	6	150	150	CD
cord-006860-a3b8hyyr	4968	7	patients	patient	NNS
cord-006860-a3b8hyyr	4968	8	)	)	-RRB-
cord-006860-a3b8hyyr	4969	1	the	the	DT
cord-006860-a3b8hyyr	4969	2	incidence	incidence	NN
cord-006860-a3b8hyyr	4969	3	of	of	IN
cord-006860-a3b8hyyr	4969	4	bleeding	bleed	VBG
cord-006860-a3b8hyyr	4969	5	and	and	CC
cord-006860-a3b8hyyr	4969	6	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	4969	7	complications	complication	NNS
cord-006860-a3b8hyyr	4969	8	were	be	VBD
cord-006860-a3b8hyyr	4969	9	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	4969	10	in	in	IN
cord-006860-a3b8hyyr	4969	11	patients	patient	NNS
cord-006860-a3b8hyyr	4969	12	who	who	WP
cord-006860-a3b8hyyr	4969	13	either	either	CC
cord-006860-a3b8hyyr	4969	14	had	have	VBD
cord-006860-a3b8hyyr	4969	15	standard	standard	JJ
cord-006860-a3b8hyyr	4969	16	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	4969	17	measurements	measurement	NNS
cord-006860-a3b8hyyr	4969	18	o	o	UH
cord-006860-a3b8hyyr	4969	19	[	[	-LRB-
cord-006860-a3b8hyyr	4969	20	performed	perform	VBN
cord-006860-a3b8hyyr	4969	21	INR	INR	NNP
cord-006860-a3b8hyyr	4969	22	-	-	HYPH
cord-006860-a3b8hyyr	4969	23	ST	ST	NNP
cord-006860-a3b8hyyr	4969	24	.	.	.
cord-006860-a3b8hyyr	4970	1	During	during	IN
cord-006860-a3b8hyyr	4970	2	a	a	DT
cord-006860-a3b8hyyr	4970	3	median	median	JJ
cord-006860-a3b8hyyr	4970	4	follow	follow	NN
cord-006860-a3b8hyyr	4970	5	-	-	HYPH
cord-006860-a3b8hyyr	4970	6	up	up	NN
cord-006860-a3b8hyyr	4970	7	of	of	IN
cord-006860-a3b8hyyr	4970	8	1.5	1.5	CD
cord-006860-a3b8hyyr	4970	9	years	year	NNS
cord-006860-a3b8hyyr	4970	10	in	in	IN
cord-006860-a3b8hyyr	4970	11	the	the	DT
cord-006860-a3b8hyyr	4970	12	group	group	NN
cord-006860-a3b8hyyr	4970	13	with	with	IN
cord-006860-a3b8hyyr	4970	14	standard	standard	JJ
cord-006860-a3b8hyyr	4970	15	oral	oral	JJ
cord-006860-a3b8hyyr	4970	16	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	4970	17	management	management	NN
cord-006860-a3b8hyyr	4970	18	an	an	DT
cord-006860-a3b8hyyr	4970	19	incidence	incidence	NN
cord-006860-a3b8hyyr	4970	20	for	for	IN
cord-006860-a3b8hyyr	4970	21	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	4970	22	of	of	IN
cord-006860-a3b8hyyr	4970	23	10.9	10.9	CD
cord-006860-a3b8hyyr	4970	24	%	%	NN
cord-006860-a3b8hyyr	4970	25	per	per	IN
cord-006860-a3b8hyyr	4970	26	year	year	NN
cord-006860-a3b8hyyr	4970	27	and	and	CC
cord-006860-a3b8hyyr	4970	28	for	for	IN
cord-006860-a3b8hyyr	4970	29	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	4970	30	complications	complication	NNS
cord-006860-a3b8hyyr	4970	31	of	of	IN
cord-006860-a3b8hyyr	4970	32	3.6	3.6	CD
cord-006860-a3b8hyyr	4970	33	%	%	NN
cord-006860-a3b8hyyr	4970	34	per	per	IN
cord-006860-a3b8hyyr	4970	35	year	year	NN
cord-006860-a3b8hyyr	4970	36	was	be	VBD
cord-006860-a3b8hyyr	4970	37	found	find	VBN
cord-006860-a3b8hyyr	4970	38	,	,	,
cord-006860-a3b8hyyr	4970	39	while	while	IN
cord-006860-a3b8hyyr	4970	40	in	in	IN
cord-006860-a3b8hyyr	4970	41	the	the	DT
cord-006860-a3b8hyyr	4970	42	group	group	NN
cord-006860-a3b8hyyr	4970	43	of	of	IN
cord-006860-a3b8hyyr	4970	44	patients	patient	NNS
cord-006860-a3b8hyyr	4970	45	with	with	IN
cord-006860-a3b8hyyr	4970	46	INR	INR	NNP
cord-006860-a3b8hyyr	4970	47	-	-	HYPH
cord-006860-a3b8hyyr	4970	48	ST	ST	NNP
cord-006860-a3b8hyyr	4970	49	bteedings	bteeding	NNS
cord-006860-a3b8hyyr	4970	50	occured	occur	VBD
cord-006860-a3b8hyyr	4970	51	with	with	IN
cord-006860-a3b8hyyr	4970	52	an	an	DT
cord-006860-a3b8hyyr	4970	53	incidence	incidence	NN
cord-006860-a3b8hyyr	4970	54	of	of	IN
cord-006860-a3b8hyyr	4970	55	4.5	4.5	CD
cord-006860-a3b8hyyr	4970	56	%	%	NN
cord-006860-a3b8hyyr	4970	57	per	per	IN
cord-006860-a3b8hyyr	4970	58	year	year	NN
cord-006860-a3b8hyyr	4970	59	and	and	CC
cord-006860-a3b8hyyr	4970	60	thromboembolisms	thromboembolism	NNS
cord-006860-a3b8hyyr	4970	61	with	with	IN
cord-006860-a3b8hyyr	4970	62	0.9	0.9	CD
cord-006860-a3b8hyyr	4970	63	%	%	NN
cord-006860-a3b8hyyr	4970	64	per	per	IN
cord-006860-a3b8hyyr	4970	65	year	year	NN
cord-006860-a3b8hyyr	4970	66	.	.	.
cord-006860-a3b8hyyr	4971	1	It	-PRON-	PRP
cord-006860-a3b8hyyr	4971	2	can	can	MD
cord-006860-a3b8hyyr	4971	3	be	be	VB
cord-006860-a3b8hyyr	4971	4	concluded	conclude	VBN
cord-006860-a3b8hyyr	4971	5	that	that	IN
cord-006860-a3b8hyyr	4971	6	INR	INR	NNP
cord-006860-a3b8hyyr	4971	7	-	-	HYPH
cord-006860-a3b8hyyr	4971	8	ST	ST	NNP
cord-006860-a3b8hyyr	4971	9	can	can	MD
cord-006860-a3b8hyyr	4971	10	be	be	VB
cord-006860-a3b8hyyr	4971	11	performed	perform	VBN
cord-006860-a3b8hyyr	4971	12	with	with	IN
cord-006860-a3b8hyyr	4971	13	high	high	JJ
cord-006860-a3b8hyyr	4971	14	accuracy	accuracy	NN
cord-006860-a3b8hyyr	4971	15	by	by	IN
cord-006860-a3b8hyyr	4971	16	the	the	DT
cord-006860-a3b8hyyr	4971	17	patients	patient	NNS
cord-006860-a3b8hyyr	4971	18	themselves	-PRON-	PRP
cord-006860-a3b8hyyr	4971	19	.	.	.
cord-006860-a3b8hyyr	4972	1	INR	INR	NNP
cord-006860-a3b8hyyr	4972	2	-	-	HYPH
cord-006860-a3b8hyyr	4972	3	ST	ST	NNP
cord-006860-a3b8hyyr	4972	4	results	result	VBZ
cord-006860-a3b8hyyr	4972	5	in	in	IN
cord-006860-a3b8hyyr	4972	6	more	more	RBR
cord-006860-a3b8hyyr	4972	7	frequent	frequent	JJ
cord-006860-a3b8hyyr	4972	8	controls	control	NNS
cord-006860-a3b8hyyr	4972	9	of	of	IN
cord-006860-a3b8hyyr	4972	10	the	the	DT
cord-006860-a3b8hyyr	4972	11	INR	INR	NNP
cord-006860-a3b8hyyr	4972	12	and	and	CC
cord-006860-a3b8hyyr	4972	13	consequently	consequently	RB
cord-006860-a3b8hyyr	4972	14	in	in	IN
cord-006860-a3b8hyyr	4972	15	significantly	significantly	RB
cord-006860-a3b8hyyr	4972	16	longer	long	JJR
cord-006860-a3b8hyyr	4972	17	time	time	NN
cord-006860-a3b8hyyr	4972	18	periods	period	NNS
cord-006860-a3b8hyyr	4972	19	where	where	WRB
cord-006860-a3b8hyyr	4972	20	the	the	DT
cord-006860-a3b8hyyr	4972	21	patients	patient	NNS
cord-006860-a3b8hyyr	4972	22	are	be	VBP
cord-006860-a3b8hyyr	4972	23	inside	inside	IN
cord-006860-a3b8hyyr	4972	24	the	the	DT
cord-006860-a3b8hyyr	4972	25	optimal	optimal	JJ
cord-006860-a3b8hyyr	4972	26	target	target	NN
cord-006860-a3b8hyyr	4972	27	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	4972	28	INR	INR	NNP
cord-006860-a3b8hyyr	4972	29	range	range	NN
cord-006860-a3b8hyyr	4972	30	.	.	.
cord-006860-a3b8hyyr	4973	1	The	the	DT
cord-006860-a3b8hyyr	4973	2	more	more	RBR
cord-006860-a3b8hyyr	4973	3	accurate	accurate	JJ
cord-006860-a3b8hyyr	4973	4	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	4973	5	management	management	NN
cord-006860-a3b8hyyr	4973	6	resulted	result	VBD
cord-006860-a3b8hyyr	4973	7	in	in	IN
cord-006860-a3b8hyyr	4973	8	our	-PRON-	PRP$
cord-006860-a3b8hyyr	4973	9	study	study	NN
cord-006860-a3b8hyyr	4973	10	group	group	NN
cord-006860-a3b8hyyr	4973	11	in	in	IN
cord-006860-a3b8hyyr	4973	12	a	a	DT
cord-006860-a3b8hyyr	4973	13	significantly	significantly	RB
cord-006860-a3b8hyyr	4973	14	lower	low	JJR
cord-006860-a3b8hyyr	4973	15	incidence	incidence	NN
cord-006860-a3b8hyyr	4973	16	of	of	IN
cord-006860-a3b8hyyr	4973	17	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	4973	18	and	and	CC
cord-006860-a3b8hyyr	4973	19	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	4973	20	complications	complication	NNS
cord-006860-a3b8hyyr	4973	21	.	.	.
cord-006860-a3b8hyyr	4974	1	The	the	DT
cord-006860-a3b8hyyr	4974	2	Cell	Cell	NNP
cord-006860-a3b8hyyr	4974	3	Biology	biology	NN
cord-006860-a3b8hyyr	4974	4	of	of	IN
cord-006860-a3b8hyyr	4974	5	Tissue	tissue	NN
cord-006860-a3b8hyyr	4974	6	Factor	factor	NN
cord-006860-a3b8hyyr	4974	7	(	(	-LRB-
cord-006860-a3b8hyyr	4974	8	Thromboplastin	Thromboplastin	NNP
cord-006860-a3b8hyyr	4974	9	)	)	-RRB-
cord-006860-a3b8hyyr	4975	1	H.	H.	NNP
cord-006860-a3b8hyyr	4975	2	prydz	prydz	NNP
cord-006860-a3b8hyyr	4975	3	,	,	,
cord-006860-a3b8hyyr	4975	4	The	the	DT
cord-006860-a3b8hyyr	4975	5	Biotechnology	Biotechnology	NNP
cord-006860-a3b8hyyr	4975	6	Centre	Centre	NNP
cord-006860-a3b8hyyr	4975	7	of	of	IN
cord-006860-a3b8hyyr	4975	8	Oslo	Oslo	NNP
cord-006860-a3b8hyyr	4975	9	,	,	,
cord-006860-a3b8hyyr	4975	10	Norway	Norway	NNP
cord-006860-a3b8hyyr	4975	11	Tissue	Tissue	NNP
cord-006860-a3b8hyyr	4975	12	Factor	Factor	NNP
cord-006860-a3b8hyyr	4975	13	(	(	-LRB-
cord-006860-a3b8hyyr	4975	14	TF	TF	NNP
cord-006860-a3b8hyyr	4975	15	,	,	,
cord-006860-a3b8hyyr	4975	16	Thromboplastin	Thromboplastin	NNP
cord-006860-a3b8hyyr	4975	17	)	)	-RRB-
cord-006860-a3b8hyyr	4975	18	is	be	VBZ
cord-006860-a3b8hyyr	4975	19	the	the	DT
cord-006860-a3b8hyyr	4975	20	most	most	RBS
cord-006860-a3b8hyyr	4975	21	potent	potent	JJ
cord-006860-a3b8hyyr	4975	22	trigger	trigger	NN
cord-006860-a3b8hyyr	4975	23	of	of	IN
cord-006860-a3b8hyyr	4975	24	blood	blood	NN
cord-006860-a3b8hyyr	4975	25	clotting	clotting	NN
cord-006860-a3b8hyyr	4976	1	knuwn.lts	knuwn.lts	NNP
cord-006860-a3b8hyyr	4976	2	presence	presence	NN
cord-006860-a3b8hyyr	4976	3	in	in	IN
cord-006860-a3b8hyyr	4976	4	tissue	tissue	NN
cord-006860-a3b8hyyr	4976	5	extracts	extract	NNS
cord-006860-a3b8hyyr	4976	6	has	have	VBZ
cord-006860-a3b8hyyr	4976	7	been	be	VBN
cord-006860-a3b8hyyr	4976	8	known	know	VBN
cord-006860-a3b8hyyr	4976	9	since	since	IN
cord-006860-a3b8hyyr	4976	10	before	before	IN
cord-006860-a3b8hyyr	4976	11	the	the	DT
cord-006860-a3b8hyyr	4976	12	turn	turn	NN
cord-006860-a3b8hyyr	4976	13	of	of	IN
cord-006860-a3b8hyyr	4976	14	the	the	DT
cord-006860-a3b8hyyr	4976	15	century	century	NN
cord-006860-a3b8hyyr	4976	16	.	.	.
cord-006860-a3b8hyyr	4977	1	Erwin	Erwin	NNP
cord-006860-a3b8hyyr	4977	2	Chargaff	Chargaff	NNP
cord-006860-a3b8hyyr	4977	3	(	(	-LRB-
cord-006860-a3b8hyyr	4977	4	of	of	IN
cord-006860-a3b8hyyr	4977	5	DNA	dna	NN
cord-006860-a3b8hyyr	4977	6	fame	fame	NN
cord-006860-a3b8hyyr	4977	7	)	)	-RRB-
cord-006860-a3b8hyyr	4977	8	first	first	RB
cord-006860-a3b8hyyr	4977	9	described	describe	VBD
cord-006860-a3b8hyyr	4977	10	that	that	IN
cord-006860-a3b8hyyr	4977	11	TF	TF	NNP
cord-006860-a3b8hyyr	4977	12	consisted	consist	VBD
cord-006860-a3b8hyyr	4977	13	of	of	IN
cord-006860-a3b8hyyr	4977	14	two	two	CD
cord-006860-a3b8hyyr	4977	15	parts	part	NNS
cord-006860-a3b8hyyr	4977	16	(	(	-LRB-
cord-006860-a3b8hyyr	4977	17	a	a	DT
cord-006860-a3b8hyyr	4977	18	protein	protein	NN
cord-006860-a3b8hyyr	4977	19	and	and	CC
cord-006860-a3b8hyyr	4977	20	a	a	DT
cord-006860-a3b8hyyr	4977	21	lipid	lipid	NN
cord-006860-a3b8hyyr	4977	22	moiety	moiety	NN
cord-006860-a3b8hyyr	4977	23	)	)	-RRB-
cord-006860-a3b8hyyr	4977	24	,	,	,
cord-006860-a3b8hyyr	4977	25	a	a	DT
cord-006860-a3b8hyyr	4977	26	fact	fact	NN
cord-006860-a3b8hyyr	4977	27	that	that	WDT
cord-006860-a3b8hyyr	4977	28	was	be	VBD
cord-006860-a3b8hyyr	4977	29	independently	independently	RB
cord-006860-a3b8hyyr	4977	30	rediscovered	rediscover	VBN
cord-006860-a3b8hyyr	4977	31	in	in	IN
cord-006860-a3b8hyyr	4977	32	the	the	DT
cord-006860-a3b8hyyr	4977	33	early	early	JJ
cord-006860-a3b8hyyr	4977	34	sixties	sixty	NNS
cord-006860-a3b8hyyr	4977	35	by	by	IN
cord-006860-a3b8hyyr	4977	36	Deutsch	Deutsch	NNP
cord-006860-a3b8hyyr	4977	37	and	and	CC
cord-006860-a3b8hyyr	4977	38	Lechner	Lechner	NNP
cord-006860-a3b8hyyr	4977	39	in	in	IN
cord-006860-a3b8hyyr	4977	40	Vienna	Vienna	NNP
cord-006860-a3b8hyyr	4977	41	and	and	CC
cord-006860-a3b8hyyr	4977	42	by	by	IN
cord-006860-a3b8hyyr	4977	43	myself	-PRON-	PRP
cord-006860-a3b8hyyr	4977	44	in	in	IN
cord-006860-a3b8hyyr	4977	45	Oslo	Oslo	NNP
cord-006860-a3b8hyyr	4977	46	.	.	.
cord-006860-a3b8hyyr	4978	1	In	in	IN
cord-006860-a3b8hyyr	4978	2	1973	1973	CD
cord-006860-a3b8hyyr	4978	3	TF	TF	NNP
cord-006860-a3b8hyyr	4978	4	was	be	VBD
cord-006860-a3b8hyyr	4978	5	first	first	RB
cord-006860-a3b8hyyr	4978	6	purified	purify	VBN
cord-006860-a3b8hyyr	4978	7	and	and	CC
cord-006860-a3b8hyyr	4978	8	shown	show	VBN
cord-006860-a3b8hyyr	4978	9	to	to	TO
cord-006860-a3b8hyyr	4978	10	be	be	VB
cord-006860-a3b8hyyr	4978	11	an	an	DT
cord-006860-a3b8hyyr	4978	12	integral	integral	JJ
cord-006860-a3b8hyyr	4978	13	membrane	membrane	NN
cord-006860-a3b8hyyr	4978	14	protein	protein	NN
cord-006860-a3b8hyyr	4978	15	of	of	IN
cord-006860-a3b8hyyr	4978	16	Mr	Mr	NNP
cord-006860-a3b8hyyr	4978	17	about	about	RB
cord-006860-a3b8hyyr	4978	18	50	50	CD
cord-006860-a3b8hyyr	4978	19	kDa	kDa	NNS
cord-006860-a3b8hyyr	4979	1	(	(	-LRB-
cord-006860-a3b8hyyr	4979	2	this	this	DT
cord-006860-a3b8hyyr	4979	3	was	be	VBD
cord-006860-a3b8hyyr	4979	4	a	a	DT
cord-006860-a3b8hyyr	4979	5	slight	slight	JJ
cord-006860-a3b8hyyr	4979	6	overestimate	overestimate	NN
cord-006860-a3b8hyyr	4979	7	,	,	,
cord-006860-a3b8hyyr	4979	8	recent	recent	JJ
cord-006860-a3b8hyyr	4979	9	studies	study	NNS
cord-006860-a3b8hyyr	4979	10	indicate	indicate	VBP
cord-006860-a3b8hyyr	4979	11	46	46	CD
cord-006860-a3b8hyyr	4979	12	-	-	SYM
cord-006860-a3b8hyyr	4979	13	48	48	CD
cord-006860-a3b8hyyr	4979	14	kDa	kDa	NNS
cord-006860-a3b8hyyr	4979	15	)	)	-RRB-
cord-006860-a3b8hyyr	4979	16	.	.	.
cord-006860-a3b8hyyr	4980	1	In	in	IN
cord-006860-a3b8hyyr	4980	2	1987	1987	CD
cord-006860-a3b8hyyr	4980	3	four	four	CD
cord-006860-a3b8hyyr	4980	4	groupes	groupe	NNS
cord-006860-a3b8hyyr	4980	5	independently	independently	RB
cord-006860-a3b8hyyr	4980	6	cloned	clone	VBD
cord-006860-a3b8hyyr	4980	7	TF	TF	NNP
cord-006860-a3b8hyyr	4980	8	eDNA	edna	NN
cord-006860-a3b8hyyr	4980	9	,	,	,
cord-006860-a3b8hyyr	4980	10	later	later	RB
cord-006860-a3b8hyyr	4980	11	also	also	RB
cord-006860-a3b8hyyr	4980	12	genomic	genomic	JJ
cord-006860-a3b8hyyr	4980	13	DNA	dna	NN
cord-006860-a3b8hyyr	4980	14	.	.	.
cord-006860-a3b8hyyr	4981	1	The	the	DT
cord-006860-a3b8hyyr	4981	2	structure	structure	NN
cord-006860-a3b8hyyr	4981	3	of	of	IN
cord-006860-a3b8hyyr	4981	4	TF	TF	NNP
cord-006860-a3b8hyyr	4981	5	suggested	suggest	VBD
cord-006860-a3b8hyyr	4981	6	that	that	IN
cord-006860-a3b8hyyr	4981	7	it	-PRON-	PRP
cord-006860-a3b8hyyr	4981	8	was	be	VBD
cord-006860-a3b8hyyr	4981	9	a	a	DT
cord-006860-a3b8hyyr	4981	10	membrane	membrane	NN
cord-006860-a3b8hyyr	4981	11	spanning	span	VBG
cord-006860-a3b8hyyr	4981	12	receptor	receptor	NN
cord-006860-a3b8hyyr	4981	13	,	,	,
cord-006860-a3b8hyyr	4981	14	with	with	IN
cord-006860-a3b8hyyr	4981	15	an	an	DT
cord-006860-a3b8hyyr	4981	16	extracellular	extracellular	JJ
cord-006860-a3b8hyyr	4981	17	part	part	NN
cord-006860-a3b8hyyr	4981	18	of	of	IN
cord-006860-a3b8hyyr	4981	19	about	about	IN
cord-006860-a3b8hyyr	4981	20	219	219	CD
cord-006860-a3b8hyyr	4981	21	amino	amino	JJ
cord-006860-a3b8hyyr	4981	22	acids	acid	NNS
cord-006860-a3b8hyyr	4981	23	folding	fold	VBG
cord-006860-a3b8hyyr	4981	24	into	into	IN
cord-006860-a3b8hyyr	4981	25	two	two	CD
cord-006860-a3b8hyyr	4981	26	domains	domain	NNS
cord-006860-a3b8hyyr	4981	27	remotely	remotely	RB
cord-006860-a3b8hyyr	4981	28	like	like	IN
cord-006860-a3b8hyyr	4981	29	the	the	DT
cord-006860-a3b8hyyr	4981	30	domains	domain	NNS
cord-006860-a3b8hyyr	4981	31	of	of	IN
cord-006860-a3b8hyyr	4981	32	the	the	DT
cord-006860-a3b8hyyr	4981	33	Ig	Ig	NNP
cord-006860-a3b8hyyr	4981	34	-	-	HYPH
cord-006860-a3b8hyyr	4981	35	superfamiliy	superfamiliy	JJ
cord-006860-a3b8hyyr	4981	36	,	,	,
cord-006860-a3b8hyyr	4981	37	and	and	CC
cord-006860-a3b8hyyr	4981	38	more	more	JJR
cord-006860-a3b8hyyr	4981	39	specifically	specifically	RB
cord-006860-a3b8hyyr	4981	40	the	the	DT
cord-006860-a3b8hyyr	4981	41	eytokine	eytokine	JJ
cord-006860-a3b8hyyr	4981	42	receptors	receptor	NNS
cord-006860-a3b8hyyr	4981	43	.	.	.
cord-006860-a3b8hyyr	4982	1	TF	TF	NNP
cord-006860-a3b8hyyr	4982	2	is	be	VBZ
cord-006860-a3b8hyyr	4982	3	synthesized	synthesize	VBN
cord-006860-a3b8hyyr	4982	4	to	to	IN
cord-006860-a3b8hyyr	4982	5	a	a	DT
cord-006860-a3b8hyyr	4982	6	varying	vary	VBG
cord-006860-a3b8hyyr	4982	7	degree	degree	NN
cord-006860-a3b8hyyr	4982	8	in	in	IN
cord-006860-a3b8hyyr	4982	9	many	many	JJ
cord-006860-a3b8hyyr	4982	10	tissues	tissue	NNS
cord-006860-a3b8hyyr	4982	11	,	,	,
cord-006860-a3b8hyyr	4982	12	but	but	CC
cord-006860-a3b8hyyr	4982	13	not	not	RB
cord-006860-a3b8hyyr	4982	14	normally	normally	RB
cord-006860-a3b8hyyr	4982	15	in	in	IN
cord-006860-a3b8hyyr	4982	16	tissues	tissue	NNS
cord-006860-a3b8hyyr	4982	17	in	in	IN
cord-006860-a3b8hyyr	4982	18	contact	contact	NN
cord-006860-a3b8hyyr	4982	19	with	with	IN
cord-006860-a3b8hyyr	4982	20	blood	blood	NN
cord-006860-a3b8hyyr	4982	21	.	.	.
cord-006860-a3b8hyyr	4983	1	However	however	RB
cord-006860-a3b8hyyr	4983	2	,	,	,
cord-006860-a3b8hyyr	4983	3	during	during	IN
cord-006860-a3b8hyyr	4983	4	acute	acute	JJ
cord-006860-a3b8hyyr	4983	5	inflammatory	inflammatory	JJ
cord-006860-a3b8hyyr	4983	6	situations	situation	NNS
cord-006860-a3b8hyyr	4983	7	and	and	CC
cord-006860-a3b8hyyr	4983	8	under	under	IN
cord-006860-a3b8hyyr	4983	9	the	the	DT
cord-006860-a3b8hyyr	4983	10	influence	influence	NN
cord-006860-a3b8hyyr	4983	11	of	of	IN
cord-006860-a3b8hyyr	4983	12	a	a	DT
cord-006860-a3b8hyyr	4983	13	number	number	NN
cord-006860-a3b8hyyr	4983	14	of	of	IN
cord-006860-a3b8hyyr	4983	15	agents	agent	NNS
cord-006860-a3b8hyyr	4983	16	(	(	-LRB-
cord-006860-a3b8hyyr	4983	17	immune	immune	JJ
cord-006860-a3b8hyyr	4983	18	cnmplexcs	cnmplexc	NNS
cord-006860-a3b8hyyr	4983	19	,	,	,
cord-006860-a3b8hyyr	4983	20	lectins	lectin	NNS
cord-006860-a3b8hyyr	4983	21	,	,	,
cord-006860-a3b8hyyr	4983	22	cytuklnes	cytuklne	NNS
cord-006860-a3b8hyyr	4983	23	,	,	,
cord-006860-a3b8hyyr	4983	24	bacterial	bacterial	JJ
cord-006860-a3b8hyyr	4983	25	components	component	NNS
cord-006860-a3b8hyyr	4983	26	,	,	,
cord-006860-a3b8hyyr	4983	27	complement	complement	VB
cord-006860-a3b8hyyr	4983	28	components	component	NNS
cord-006860-a3b8hyyr	4983	29	etc	etc	FW
cord-006860-a3b8hyyr	4983	30	)	)	-RRB-
cord-006860-a3b8hyyr	4983	31	monucytes	monucyte	NNS
cord-006860-a3b8hyyr	4983	32	and	and	CC
cord-006860-a3b8hyyr	4983	33	vascular	vascular	JJ
cord-006860-a3b8hyyr	4983	34	endothelial	endothelial	JJ
cord-006860-a3b8hyyr	4983	35	cells	cell	NNS
cord-006860-a3b8hyyr	4983	36	are	be	VBP
cord-006860-a3b8hyyr	4983	37	induced	induce	VBN
cord-006860-a3b8hyyr	4983	38	to	to	TO
cord-006860-a3b8hyyr	4983	39	synthesize	synthesize	VB
cord-006860-a3b8hyyr	4983	40	TF	TF	NNP
cord-006860-a3b8hyyr	4983	41	.	.	.
cord-006860-a3b8hyyr	4984	1	Another	another	DT
cord-006860-a3b8hyyr	4984	2	possible	possible	JJ
cord-006860-a3b8hyyr	4984	3	way	way	NN
cord-006860-a3b8hyyr	4984	4	tu	tu	NNP
cord-006860-a3b8hyyr	4984	5	get	get	VB
cord-006860-a3b8hyyr	4984	6	TF	TF	NNP
cord-006860-a3b8hyyr	4984	7	into	into	IN
cord-006860-a3b8hyyr	4984	8	contact	contact	NN
cord-006860-a3b8hyyr	4984	9	with	with	IN
cord-006860-a3b8hyyr	4984	10	blood	blood	NN
cord-006860-a3b8hyyr	4984	11	is	be	VBZ
cord-006860-a3b8hyyr	4984	12	thruugh	thruugh	NNP
cord-006860-a3b8hyyr	4984	13	trauma	trauma	NN
cord-006860-a3b8hyyr	4984	14	,	,	,
cord-006860-a3b8hyyr	4984	15	surgical	surgical	JJ
cord-006860-a3b8hyyr	4984	16	ur	ur	NN
cord-006860-a3b8hyyr	4984	17	otherwise	otherwise	RB
cord-006860-a3b8hyyr	4984	18	.	.	.
cord-006860-a3b8hyyr	4985	1	The	the	DT
cord-006860-a3b8hyyr	4985	2	fact	fact	NN
cord-006860-a3b8hyyr	4985	3	that	that	IN
cord-006860-a3b8hyyr	4985	4	TF	TF	NNP
cord-006860-a3b8hyyr	4985	5	is	be	VBZ
cord-006860-a3b8hyyr	4985	6	inducible	inducible	JJ
cord-006860-a3b8hyyr	4985	7	has	have	VBZ
cord-006860-a3b8hyyr	4985	8	created	create	VBN
cord-006860-a3b8hyyr	4985	9	a	a	DT
cord-006860-a3b8hyyr	4985	10	lot	lot	NN
cord-006860-a3b8hyyr	4985	11	uf	uf	CD
cord-006860-a3b8hyyr	4985	12	interest	interest	NN
cord-006860-a3b8hyyr	4985	13	in	in	IN
cord-006860-a3b8hyyr	4985	14	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4985	15	cell	cell	NN
cord-006860-a3b8hyyr	4985	16	biology	biology	NN
cord-006860-a3b8hyyr	4985	17	.	.	.
cord-006860-a3b8hyyr	4986	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4986	2	reported	report	VBD
cord-006860-a3b8hyyr	4986	3	recently	recently	RB
cord-006860-a3b8hyyr	4986	4	that	that	IN
cord-006860-a3b8hyyr	4986	5	binding	binding	NN
cord-006860-a3b8hyyr	4986	6	of	of	IN
cord-006860-a3b8hyyr	4986	7	Factor	Factor	NNP
cord-006860-a3b8hyyr	4986	8	VIIa	VIIa	NNS
cord-006860-a3b8hyyr	4986	9	tu	tu	NNP
cord-006860-a3b8hyyr	4986	10	TF	TF	NNP
cord-006860-a3b8hyyr	4986	11	un	un	NNP
cord-006860-a3b8hyyr	4986	12	the	the	DT
cord-006860-a3b8hyyr	4986	13	cell	cell	NN
cord-006860-a3b8hyyr	4986	14	surface	surface	NN
cord-006860-a3b8hyyr	4986	15	elicited	elicit	VBD
cord-006860-a3b8hyyr	4986	16	a	a	DT
cord-006860-a3b8hyyr	4986	17	marked	marked	JJ
cord-006860-a3b8hyyr	4986	18	increase	increase	NN
cord-006860-a3b8hyyr	4986	19	in	in	IN
cord-006860-a3b8hyyr	4986	20	intracenular	intracenular	NNP
cord-006860-a3b8hyyr	4987	1	Ca	ca	NN
cord-006860-a3b8hyyr	4987	2	spikes	spike	NNS
cord-006860-a3b8hyyr	4987	3	,	,	,
cord-006860-a3b8hyyr	4987	4	thus	thus	RB
cord-006860-a3b8hyyr	4987	5	rendering	render	VBG
cord-006860-a3b8hyyr	4987	6	the	the	DT
cord-006860-a3b8hyyr	4987	7	final	final	JJ
cord-006860-a3b8hyyr	4987	8	proof	proof	NN
cord-006860-a3b8hyyr	4987	9	that	that	WDT
cord-006860-a3b8hyyr	4987	10	TF	TF	NNP
cord-006860-a3b8hyyr	4987	11	not	not	RB
cord-006860-a3b8hyyr	4987	12	only	only	RB
cord-006860-a3b8hyyr	4987	13	luoks	luok	NNS
cord-006860-a3b8hyyr	4987	14	like	like	IN
cord-006860-a3b8hyyr	4987	15	a	a	DT
cord-006860-a3b8hyyr	4987	16	receptor	receptor	NN
cord-006860-a3b8hyyr	4987	17	but	but	CC
cord-006860-a3b8hyyr	4987	18	really	really	RB
cord-006860-a3b8hyyr	4987	19	is	be	VBZ
cord-006860-a3b8hyyr	4987	20	one	one	CD
cord-006860-a3b8hyyr	4987	21	,	,	,
cord-006860-a3b8hyyr	4987	22	since	since	IN
cord-006860-a3b8hyyr	4987	23	all	all	PDT
cord-006860-a3b8hyyr	4987	24	the	the	DT
cord-006860-a3b8hyyr	4987	25	three	three	CD
cord-006860-a3b8hyyr	4987	26	essential	essential	JJ
cord-006860-a3b8hyyr	4987	27	criteria	criterion	NNS
cord-006860-a3b8hyyr	4987	28	are	be	VBP
cord-006860-a3b8hyyr	4987	29	fulfilled	fulfil	VBN
cord-006860-a3b8hyyr	4987	30	:	:	:
cord-006860-a3b8hyyr	4987	31	TF	TF	NNP
cord-006860-a3b8hyyr	4987	32	has	have	VBZ
cord-006860-a3b8hyyr	4987	33	a	a	DT
cord-006860-a3b8hyyr	4987	34	transmembrane	transmembrane	NN
cord-006860-a3b8hyyr	4987	35	segment	segment	NN
cord-006860-a3b8hyyr	4987	36	and	and	CC
cord-006860-a3b8hyyr	4987	37	a	a	DT
cord-006860-a3b8hyyr	4987	38	cytoplasmic	cytoplasmic	JJ
cord-006860-a3b8hyyr	4987	39	tail	tail	NN
cord-006860-a3b8hyyr	4987	40	TF	TF	NNP
cord-006860-a3b8hyyr	4987	41	has	have	VBZ
cord-006860-a3b8hyyr	4987	42	a	a	DT
cord-006860-a3b8hyyr	4987	43	high	high	JJ
cord-006860-a3b8hyyr	4987	44	specificity	specificity	NN
cord-006860-a3b8hyyr	4987	45	/	/	SYM
cord-006860-a3b8hyyr	4987	46	high	high	JJ
cord-006860-a3b8hyyr	4987	47	affinity	affinity	NN
cord-006860-a3b8hyyr	4987	48	ligaud	ligaud	NN
cord-006860-a3b8hyyr	4987	49	(	(	-LRB-
cord-006860-a3b8hyyr	4988	1	Factor	factor	NN
cord-006860-a3b8hyyr	4988	2	VII	VII	NNP
cord-006860-a3b8hyyr	4988	3	and	and	CC
cord-006860-a3b8hyyr	4988	4	Factor	Factor	NNP
cord-006860-a3b8hyyr	4988	5	X	X	NNP
cord-006860-a3b8hyyr	4988	6	)	)	-RRB-
cord-006860-a3b8hyyr	4988	7	TF	TF	NNP
cord-006860-a3b8hyyr	4988	8	induces	induce	VBZ
cord-006860-a3b8hyyr	4988	9	an	an	DT
cord-006860-a3b8hyyr	4988	10	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	4988	11	signal	signal	NN
cord-006860-a3b8hyyr	4988	12	upon	upon	IN
cord-006860-a3b8hyyr	4988	13	ligand	ligand	NN
cord-006860-a3b8hyyr	4988	14	binding	bind	VBG
cord-006860-a3b8hyyr	4988	15	Recent	recent	JJ
cord-006860-a3b8hyyr	4988	16	results	result	NNS
cord-006860-a3b8hyyr	4988	17	regarding	regard	VBG
cord-006860-a3b8hyyr	4988	18	TF	TF	NNP
cord-006860-a3b8hyyr	4988	19	as	as	IN
cord-006860-a3b8hyyr	4988	20	a	a	DT
cord-006860-a3b8hyyr	4988	21	receptor	receptor	NN
cord-006860-a3b8hyyr	4988	22	and	and	CC
cord-006860-a3b8hyyr	4988	23	regarding	regard	VBG
cord-006860-a3b8hyyr	4988	24	its	-PRON-	PRP$
cord-006860-a3b8hyyr	4988	25	intracellular	intracellular	JJ
cord-006860-a3b8hyyr	4988	26	traffic	traffic	NN
cord-006860-a3b8hyyr	4988	27	will	will	MD
cord-006860-a3b8hyyr	4988	28	be	be	VB
cord-006860-a3b8hyyr	4988	29	reported	report	VBN
cord-006860-a3b8hyyr	4988	30	.	.	.
cord-006860-a3b8hyyr	4989	1	Both	both	DT
cord-006860-a3b8hyyr	4989	2	F.IX	F.IX	NNP
cord-006860-a3b8hyyr	4989	3	and	and	CC
cord-006860-a3b8hyyr	4989	4	F.X	F.X	NNP
cord-006860-a3b8hyyr	4989	5	are	be	VBP
cord-006860-a3b8hyyr	4989	6	activated	activate	VBN
cord-006860-a3b8hyyr	4989	7	by	by	IN
cord-006860-a3b8hyyr	4989	8	the	the	DT
cord-006860-a3b8hyyr	4989	9	TF	TF	NNP
cord-006860-a3b8hyyr	4989	10	/	/	SYM
cord-006860-a3b8hyyr	4989	11	F.VIIa	F.VIIa	NNP
cord-006860-a3b8hyyr	4989	12	complex	complex	NN
cord-006860-a3b8hyyr	4989	13	.	.	.
cord-006860-a3b8hyyr	4990	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4990	2	have	have	VBP
cord-006860-a3b8hyyr	4990	3	used	use	VBN
cord-006860-a3b8hyyr	4990	4	a	a	DT
cord-006860-a3b8hyyr	4990	5	TF	tf	NN
cord-006860-a3b8hyyr	4990	6	-	-	HYPH
cord-006860-a3b8hyyr	4990	7	initiated	initiate	VBN
cord-006860-a3b8hyyr	4990	8	model	model	NN
cord-006860-a3b8hyyr	4990	9	system	system	NN
cord-006860-a3b8hyyr	4990	10	to	to	TO
cord-006860-a3b8hyyr	4990	11	examine	examine	VB
cord-006860-a3b8hyyr	4990	12	the	the	DT
cord-006860-a3b8hyyr	4990	13	roles	role	NNS
cord-006860-a3b8hyyr	4990	14	played	play	VBN
cord-006860-a3b8hyyr	4990	15	by	by	IN
cord-006860-a3b8hyyr	4990	16	F.IXa	F.IXa	NNP
cord-006860-a3b8hyyr	4990	17	and	and	CC
cord-006860-a3b8hyyr	4990	18	F.Xa	F.Xa	NNPS
cord-006860-a3b8hyyr	4990	19	in	in	IN
cord-006860-a3b8hyyr	4990	20	initiating	initiate	VBG
cord-006860-a3b8hyyr	4990	21	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4990	22	.	.	.
cord-006860-a3b8hyyr	4991	1	The	the	DT
cord-006860-a3b8hyyr	4991	2	in	in	FW
cord-006860-a3b8hyyr	4991	3	vitro	vitro	FW
cord-006860-a3b8hyyr	4991	4	model	model	NN
cord-006860-a3b8hyyr	4991	5	contained	contain	VBD
cord-006860-a3b8hyyr	4991	6	a	a	DT
cord-006860-a3b8hyyr	4991	7	cellular	cellular	JJ
cord-006860-a3b8hyyr	4991	8	TF	tf	NN
cord-006860-a3b8hyyr	4991	9	source	source	NN
cord-006860-a3b8hyyr	4991	10	;	;	:
cord-006860-a3b8hyyr	4991	11	plasma	plasma	NN
cord-006860-a3b8hyyr	4991	12	concentrations	concentration	NNS
cord-006860-a3b8hyyr	4991	13	of	of	IN
cord-006860-a3b8hyyr	4991	14	F.II	F.II	NNP
cord-006860-a3b8hyyr	4991	15	,	,	,
cord-006860-a3b8hyyr	4991	16	V	v	NN
cord-006860-a3b8hyyr	4991	17	,	,	,
cord-006860-a3b8hyyr	4991	18	VIII	VIII	NNP
cord-006860-a3b8hyyr	4991	19	,	,	,
cord-006860-a3b8hyyr	4991	20	IX	IX	NNP
cord-006860-a3b8hyyr	4991	21	and	and	CC
cord-006860-a3b8hyyr	4991	22	X	X	NNP
cord-006860-a3b8hyyr	4991	23	,	,	,
cord-006860-a3b8hyyr	4991	24	tissue	tissue	NN
cord-006860-a3b8hyyr	4991	25	factor	factor	NN
cord-006860-a3b8hyyr	4991	26	pathway	pathway	NN
cord-006860-a3b8hyyr	4991	27	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	4991	28	and	and	CC
cord-006860-a3b8hyyr	4991	29	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	4991	30	III	III	NNP
cord-006860-a3b8hyyr	4991	31	.	.	.
cord-006860-a3b8hyyr	4992	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4992	2	tested	test	VBD
cord-006860-a3b8hyyr	4992	3	the	the	DT
cord-006860-a3b8hyyr	4992	4	ability	ability	NN
cord-006860-a3b8hyyr	4992	5	of	of	IN
cord-006860-a3b8hyyr	4992	6	exogenously	exogenously	RB
cord-006860-a3b8hyyr	4992	7	added	add	VBN
cord-006860-a3b8hyyr	4992	8	F.IXa	F.IXa	NNP
cord-006860-a3b8hyyr	4992	9	or	or	CC
cord-006860-a3b8hyyr	4992	10	F.Xa	F.Xa	NNP
cord-006860-a3b8hyyr	4992	11	to	to	TO
cord-006860-a3b8hyyr	4992	12	substitute	substitute	VB
cord-006860-a3b8hyyr	4992	13	for	for	IN
cord-006860-a3b8hyyr	4992	14	TF	TF	NNP
cord-006860-a3b8hyyr	4992	15	/	/	SYM
cord-006860-a3b8hyyr	4992	16	VIIa	VIIa	NNS
cord-006860-a3b8hyyr	4992	17	activity	activity	NN
cord-006860-a3b8hyyr	4992	18	in	in	IN
cord-006860-a3b8hyyr	4992	19	initiating	initiate	VBG
cord-006860-a3b8hyyr	4992	20	platelet	platelet	NN
cord-006860-a3b8hyyr	4992	21	activation	activation	NN
cord-006860-a3b8hyyr	4992	22	and	and	CC
cord-006860-a3b8hyyr	4992	23	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	4992	24	generation	generation	NN
cord-006860-a3b8hyyr	4992	25	.	.	.
cord-006860-a3b8hyyr	4993	1	F.Xa	F.Xa	NNP
cord-006860-a3b8hyyr	4993	2	was	be	VBD
cord-006860-a3b8hyyr	4993	3	10	10	CD
cord-006860-a3b8hyyr	4993	4	times	time	NNS
cord-006860-a3b8hyyr	4993	5	more	more	RBR
cord-006860-a3b8hyyr	4993	6	potent	potent	JJ
cord-006860-a3b8hyyr	4993	7	than	than	IN
cord-006860-a3b8hyyr	4993	8	F.IXa	F.IXa	NNP
cord-006860-a3b8hyyr	4993	9	in	in	IN
cord-006860-a3b8hyyr	4993	10	initiating	initiate	VBG
cord-006860-a3b8hyyr	4993	11	platelet	platelet	NN
cord-006860-a3b8hyyr	4993	12	activation	activation	NN
cord-006860-a3b8hyyr	4993	13	,	,	,
cord-006860-a3b8hyyr	4993	14	but	but	CC
cord-006860-a3b8hyyr	4993	15	F.IXa	F.IXa	NNP
cord-006860-a3b8hyyr	4993	16	was	be	VBD
cord-006860-a3b8hyyr	4993	17	more	more	RBR
cord-006860-a3b8hyyr	4993	18	potent	potent	JJ
cord-006860-a3b8hyyr	4993	19	in	in	IN
cord-006860-a3b8hyyr	4993	20	promoting	promote	VBG
cord-006860-a3b8hyyr	4993	21	IIa	IIa	NNP
cord-006860-a3b8hyyr	4993	22	generation	generation	NN
cord-006860-a3b8hyyr	4993	23	.	.	.
cord-006860-a3b8hyyr	4994	1	In	in	IN
cord-006860-a3b8hyyr	4994	2	the	the	DT
cord-006860-a3b8hyyr	4994	3	presence	presence	NN
cord-006860-a3b8hyyr	4994	4	of	of	IN
cord-006860-a3b8hyyr	4994	5	TF	TF	NNP
cord-006860-a3b8hyyr	4994	6	/	/	SYM
cord-006860-a3b8hyyr	4994	7	VIIa	VIIa	NNS
cord-006860-a3b8hyyr	4994	8	,	,	,
cord-006860-a3b8hyyr	4994	9	zymogen	zymogen	NNP
cord-006860-a3b8hyyr	4994	10	F.X	F.X	NNP
cord-006860-a3b8hyyr	4994	11	was	be	VBD
cord-006860-a3b8hyyr	4994	12	required	require	VBN
cord-006860-a3b8hyyr	4994	13	both	both	CC
cord-006860-a3b8hyyr	4994	14	for	for	IN
cord-006860-a3b8hyyr	4994	15	platelet	platelet	NN
cord-006860-a3b8hyyr	4994	16	activation	activation	NN
cord-006860-a3b8hyyr	4994	17	and	and	CC
cord-006860-a3b8hyyr	4994	18	IIa	IIa	NNP
cord-006860-a3b8hyyr	4994	19	generation	generation	NN
cord-006860-a3b8hyyr	4994	20	,	,	,
cord-006860-a3b8hyyr	4994	21	while	while	IN
cord-006860-a3b8hyyr	4994	22	F.IX	F.IX	NNP
cord-006860-a3b8hyyr	4994	23	was	be	VBD
cord-006860-a3b8hyyr	4994	24	only	only	RB
cord-006860-a3b8hyyr	4994	25	required	require	VBN
cord-006860-a3b8hyyr	4994	26	for	for	IN
cord-006860-a3b8hyyr	4994	27	IIa	IIa	NNP
cord-006860-a3b8hyyr	4994	28	generation	generation	NN
cord-006860-a3b8hyyr	4994	29	.	.	.
cord-006860-a3b8hyyr	4995	1	Thus	thus	RB
cord-006860-a3b8hyyr	4995	2	,	,	,
cord-006860-a3b8hyyr	4995	3	TF	TF	NNP
cord-006860-a3b8hyyr	4995	4	/	/	SYM
cord-006860-a3b8hyyr	4995	5	VIIa	VIIa	NNS
cord-006860-a3b8hyyr	4995	6	-	-	HYPH
cord-006860-a3b8hyyr	4995	7	activated	activate	VBN
cord-006860-a3b8hyyr	4995	8	F.IXa	F.IXa	NNP
cord-006860-a3b8hyyr	4995	9	and	and	CC
cord-006860-a3b8hyyr	4995	10	F.Xa	F.Xa	NNP
cord-006860-a3b8hyyr	4995	11	have	have	VBP
cord-006860-a3b8hyyr	4995	12	distinct	distinct	JJ
cord-006860-a3b8hyyr	4995	13	physiological	physiological	JJ
cord-006860-a3b8hyyr	4995	14	roles	role	NNS
cord-006860-a3b8hyyr	4995	15	.	.	.
cord-006860-a3b8hyyr	4996	1	The	the	DT
cord-006860-a3b8hyyr	4996	2	main	main	JJ
cord-006860-a3b8hyyr	4996	3	role	role	NN
cord-006860-a3b8hyyr	4996	4	of	of	IN
cord-006860-a3b8hyyr	4996	5	F.Xa	F.Xa	NNP
cord-006860-a3b8hyyr	4996	6	is	be	VBZ
cord-006860-a3b8hyyr	4996	7	to	to	TO
cord-006860-a3b8hyyr	4996	8	activate	activate	VB
cord-006860-a3b8hyyr	4996	9	platelets	platelet	NNS
cord-006860-a3b8hyyr	4996	10	by	by	IN
cord-006860-a3b8hyyr	4996	11	producing	produce	VBG
cord-006860-a3b8hyyr	4996	12	an	an	DT
cord-006860-a3b8hyyr	4996	13	initial	initial	JJ
cord-006860-a3b8hyyr	4996	14	small	small	JJ
cord-006860-a3b8hyyr	4996	15	amount	amount	NN
cord-006860-a3b8hyyr	4996	16	of	of	IN
cord-006860-a3b8hyyr	4996	17	IIa	IIa	NNP
cord-006860-a3b8hyyr	4996	18	.	.	.
cord-006860-a3b8hyyr	4997	1	The	the	DT
cord-006860-a3b8hyyr	4997	2	process	process	NN
cord-006860-a3b8hyyr	4997	3	of	of	IN
cord-006860-a3b8hyyr	4997	4	platelet	platelet	NN
cord-006860-a3b8hyyr	4997	5	activation	activation	NN
cord-006860-a3b8hyyr	4997	6	is	be	VBZ
cord-006860-a3b8hyyr	4997	7	much	much	RB
cord-006860-a3b8hyyr	4997	8	more	more	RBR
cord-006860-a3b8hyyr	4997	9	efficient	efficient	JJ
cord-006860-a3b8hyyr	4997	10	if	if	IN
cord-006860-a3b8hyyr	4997	11	this	this	DT
cord-006860-a3b8hyyr	4997	12	initial	initial	JJ
cord-006860-a3b8hyyr	4997	13	IIa	IIa	NNP
cord-006860-a3b8hyyr	4997	14	is	be	VBZ
cord-006860-a3b8hyyr	4997	15	produced	produce	VBN
cord-006860-a3b8hyyr	4997	16	on	on	IN
cord-006860-a3b8hyyr	4997	17	the	the	DT
cord-006860-a3b8hyyr	4997	18	TF	tf	NN
cord-006860-a3b8hyyr	4997	19	-	-	HYPH
cord-006860-a3b8hyyr	4997	20	bearing	bear	VBG
cord-006860-a3b8hyyr	4997	21	surface	surface	NN
cord-006860-a3b8hyyr	4997	22	.	.	.
cord-006860-a3b8hyyr	4998	1	F.IXa	F.IXa	NNP
cord-006860-a3b8hyyr	4998	2	,	,	,
cord-006860-a3b8hyyr	4998	3	by	by	IN
cord-006860-a3b8hyyr	4998	4	contrast	contrast	NN
cord-006860-a3b8hyyr	4998	5	,	,	,
cord-006860-a3b8hyyr	4998	6	enhances	enhance	VBZ
cord-006860-a3b8hyyr	4998	7	IIa	IIa	NNP
cord-006860-a3b8hyyr	4998	8	generation	generation	NN
cord-006860-a3b8hyyr	4998	9	on	on	IN
cord-006860-a3b8hyyr	4998	10	platelets	platelet	NNS
cord-006860-a3b8hyyr	4998	11	by	by	IN
cord-006860-a3b8hyyr	4998	12	providing	provide	VBG
cord-006860-a3b8hyyr	4998	13	F.Xa	F.Xa	NNP
cord-006860-a3b8hyyr	4998	14	for	for	IN
cord-006860-a3b8hyyr	4998	15	platelet	platelet	NN
cord-006860-a3b8hyyr	4998	16	surface	surface	NN
cord-006860-a3b8hyyr	4998	17	prothrombinase	prothrombinase	NNP
cord-006860-a3b8hyyr	4998	18	assembly	assembly	NNP
cord-006860-a3b8hyyr	4998	19	.	.	.
cord-006860-a3b8hyyr	4999	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	4999	2	conclude	conclude	VBP
cord-006860-a3b8hyyr	4999	3	that	that	DT
cord-006860-a3b8hyyr	4999	4	activation	activation	NN
cord-006860-a3b8hyyr	4999	5	of	of	IN
cord-006860-a3b8hyyr	4999	6	both	both	CC
cord-006860-a3b8hyyr	4999	7	F.IX	F.IX	NNP
cord-006860-a3b8hyyr	4999	8	and	and	CC
cord-006860-a3b8hyyr	4999	9	F.X	F.X	NNP
cord-006860-a3b8hyyr	4999	10	by	by	IN
cord-006860-a3b8hyyr	4999	11	TF	TF	NNP
cord-006860-a3b8hyyr	4999	12	/	/	SYM
cord-006860-a3b8hyyr	4999	13	VIIa	VIIa	NNS
cord-006860-a3b8hyyr	4999	14	is	be	VBZ
cord-006860-a3b8hyyr	4999	15	essential	essential	JJ
cord-006860-a3b8hyyr	4999	16	for	for	IN
cord-006860-a3b8hyyr	4999	17	efficient	efficient	JJ
cord-006860-a3b8hyyr	4999	18	initiation	initiation	NN
cord-006860-a3b8hyyr	4999	19	of	of	IN
cord-006860-a3b8hyyr	4999	20	coagulation	coagulation	NN
cord-006860-a3b8hyyr	4999	21	.	.	.
cord-006860-a3b8hyyr	5000	1	Furthermore	furthermore	RB
cord-006860-a3b8hyyr	5000	2	,	,	,
cord-006860-a3b8hyyr	5000	3	F.X	F.X	NNP
cord-006860-a3b8hyyr	5000	4	activated	activate	VBD
cord-006860-a3b8hyyr	5000	5	on	on	IN
cord-006860-a3b8hyyr	5000	6	the	the	DT
cord-006860-a3b8hyyr	5000	7	surface	surface	NN
cord-006860-a3b8hyyr	5000	8	of	of	IN
cord-006860-a3b8hyyr	5000	9	a	a	DT
cord-006860-a3b8hyyr	5000	10	TF	tf	NN
cord-006860-a3b8hyyr	5000	11	-	-	HYPH
cord-006860-a3b8hyyr	5000	12	bearing	bear	VBG
cord-006860-a3b8hyyr	5000	13	cell	cell	NN
cord-006860-a3b8hyyr	5000	14	isnot	isnot	RB
cord-006860-a3b8hyyr	5000	15	functionally	functionally	RB
cord-006860-a3b8hyyr	5000	16	equi.valent	equi.valent	JJ
cord-006860-a3b8hyyr	5000	17	to	to	IN
cord-006860-a3b8hyyr	5000	18	F.X	f.x	NN
cord-006860-a3b8hyyr	5000	19	activated	activate	VBN
cord-006860-a3b8hyyr	5000	20	on	on	IN
cord-006860-a3b8hyyr	5000	21	the	the	DT
cord-006860-a3b8hyyr	5000	22	platelet	platelet	NN
cord-006860-a3b8hyyr	5000	23	surface	surface	NN
cord-006860-a3b8hyyr	5000	24	.	.	.
cord-006860-a3b8hyyr	5001	1	Therefore	therefore	RB
cord-006860-a3b8hyyr	5001	2	,	,	,
cord-006860-a3b8hyyr	5001	3	F.X	F.X	NNP
cord-006860-a3b8hyyr	5001	4	activation	activation	NN
cord-006860-a3b8hyyr	5001	5	by	by	IN
cord-006860-a3b8hyyr	5001	6	TF	TF	NNP
cord-006860-a3b8hyyr	5001	7	/	/	SYM
cord-006860-a3b8hyyr	5001	8	VIIa	VIIa	NNS
cord-006860-a3b8hyyr	5001	9	does	do	VBZ
cord-006860-a3b8hyyr	5001	10	not	not	RB
cord-006860-a3b8hyyr	5001	11	compensate	compensate	VB
cord-006860-a3b8hyyr	5001	12	for	for	IN
cord-006860-a3b8hyyr	5001	13	a	a	DT
cord-006860-a3b8hyyr	5001	14	lack	lack	NN
cord-006860-a3b8hyyr	5001	15	of	of	IN
cord-006860-a3b8hyyr	5001	16	F.IX	F.IX	NNS
cord-006860-a3b8hyyr	5001	17	or	or	CC
cord-006860-a3b8hyyr	5001	18	VIII	VIII	NNP
cord-006860-a3b8hyyr	5001	19	in	in	IN
cord-006860-a3b8hyyr	5001	20	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	5001	21	because	because	IN
cord-006860-a3b8hyyr	5001	22	the	the	DT
cord-006860-a3b8hyyr	5001	23	F.Xa	F.Xa	NNP
cord-006860-a3b8hyyr	5001	24	activated	activate	VBN
cord-006860-a3b8hyyr	5001	25	by	by	IN
cord-006860-a3b8hyyr	5001	26	TF	TF	NNP
cord-006860-a3b8hyyr	5001	27	/	/	SYM
cord-006860-a3b8hyyr	5001	28	VIIa	VIIa	NNS
cord-006860-a3b8hyyr	5001	29	is	be	VBZ
cord-006860-a3b8hyyr	5001	30	located	locate	VBN
cord-006860-a3b8hyyr	5001	31	on	on	IN
cord-006860-a3b8hyyr	5001	32	the	the	DT
cord-006860-a3b8hyyr	5001	33	wrong	wrong	JJ
cord-006860-a3b8hyyr	5001	34	surface	surface	NN
cord-006860-a3b8hyyr	5001	35	for	for	IN
cord-006860-a3b8hyyr	5001	36	efficient	efficient	JJ
cord-006860-a3b8hyyr	5001	37	thrombin	thrombin	NN
cord-006860-a3b8hyyr	5001	38	generation	generation	NN
cord-006860-a3b8hyyr	5001	39	.	.	.
cord-006860-a3b8hyyr	5002	1	Our	-PRON-	PRP$
cord-006860-a3b8hyyr	5002	2	results	result	NNS
cord-006860-a3b8hyyr	5002	3	emphasize	emphasize	VBP
cord-006860-a3b8hyyr	5002	4	that	that	IN
cord-006860-a3b8hyyr	5002	5	the	the	DT
cord-006860-a3b8hyyr	5002	6	location	location	NN
cord-006860-a3b8hyyr	5002	7	,	,	,
cord-006860-a3b8hyyr	5002	8	of	of	IN
cord-006860-a3b8hyyr	5002	9	an	an	DT
cord-006860-a3b8hyyr	5002	10	activated	activate	VBN
cord-006860-a3b8hyyr	5002	11	coagulation	coagulation	NN
cord-006860-a3b8hyyr	5002	12	factor	factor	NN
cord-006860-a3b8hyyr	5002	13	is	be	VBZ
cord-006860-a3b8hyyr	5002	14	a	a	DT
cord-006860-a3b8hyyr	5002	15	critical	critical	JJ
cord-006860-a3b8hyyr	5002	16	determinant	determinant	NN
cord-006860-a3b8hyyr	5002	17	of	of	IN
cord-006860-a3b8hyyr	5002	18	its	-PRON-	PRP$
cord-006860-a3b8hyyr	5002	19	role	role	NN
cord-006860-a3b8hyyr	5002	20	in	in	IN
cord-006860-a3b8hyyr	5002	21	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	5002	22	.	.	.
cord-006860-a3b8hyyr	5003	1	The	the	DT
cord-006860-a3b8hyyr	5003	2	X	x	NN
cord-006860-a3b8hyyr	5003	3	-	-	NN
cord-006860-a3b8hyyr	5003	4	ray	ray	JJ
cord-006860-a3b8hyyr	5003	5	crystallographic	crystallographic	JJ
cord-006860-a3b8hyyr	5003	6	structure	structure	NN
cord-006860-a3b8hyyr	5003	7	of	of	IN
cord-006860-a3b8hyyr	5003	8	the	the	DT
cord-006860-a3b8hyyr	5003	9	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5003	10	-	-	HYPH
cord-006860-a3b8hyyr	5003	11	TF	TF	NNP
cord-006860-a3b8hyyr	5003	12	complex	complex	NN
cord-006860-a3b8hyyr	5003	13	located	locate	VBD
cord-006860-a3b8hyyr	5003	14	the	the	DT
cord-006860-a3b8hyyr	5003	15	areas	area	NNS
cord-006860-a3b8hyyr	5003	16	within	within	IN
cord-006860-a3b8hyyr	5003	17	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5003	18	in	in	IN
cord-006860-a3b8hyyr	5003	19	contact	contact	NN
cord-006860-a3b8hyyr	5003	20	with	with	IN
cord-006860-a3b8hyyr	5003	21	TF	TF	NNP
cord-006860-a3b8hyyr	5003	22	to	to	IN
cord-006860-a3b8hyyr	5003	23	the	the	DT
cord-006860-a3b8hyyr	5003	24	first	first	JJ
cord-006860-a3b8hyyr	5003	25	EGFlike	EGFlike	NNS
cord-006860-a3b8hyyr	5003	26	and	and	CC
cord-006860-a3b8hyyr	5003	27	the	the	DT
cord-006860-a3b8hyyr	5003	28	protease	protease	NN
cord-006860-a3b8hyyr	5003	29	domains	domain	NNS
cord-006860-a3b8hyyr	5003	30	.	.	.
cord-006860-a3b8hyyr	5004	1	High	high	JJ
cord-006860-a3b8hyyr	5004	2	-	-	HYPH
cord-006860-a3b8hyyr	5004	3	affinity	affinity	NN
cord-006860-a3b8hyyr	5004	4	binding	binding	NN
cord-006860-a3b8hyyr	5004	5	of	of	IN
cord-006860-a3b8hyyr	5004	6	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5004	7	to	to	IN
cord-006860-a3b8hyyr	5004	8	TF	TF	NNP
cord-006860-a3b8hyyr	5004	9	depends	depend	VBZ
cord-006860-a3b8hyyr	5004	10	on	on	IN
cord-006860-a3b8hyyr	5004	11	Ca2	ca2	CD
cord-006860-a3b8hyyr	5004	12	+	+	CC
cord-006860-a3b8hyyr	5004	13	and	and	CC
cord-006860-a3b8hyyr	5004	14	previous	previous	JJ
cord-006860-a3b8hyyr	5004	15	studies	study	NNS
cord-006860-a3b8hyyr	5004	16	suggest	suggest	VBP
cord-006860-a3b8hyyr	5004	17	that	that	IN
cord-006860-a3b8hyyr	5004	18	Ca2	ca2	NN
cord-006860-a3b8hyyr	5004	19	+	+	SYM
cord-006860-a3b8hyyr	5004	20	binding	bind	VBG
cord-006860-a3b8hyyr	5004	21	to	to	IN
cord-006860-a3b8hyyr	5004	22	a	a	DT
cord-006860-a3b8hyyr	5004	23	site	site	NN
cord-006860-a3b8hyyr	5004	24	in	in	IN
cord-006860-a3b8hyyr	5004	25	the	the	DT
cord-006860-a3b8hyyr	5004	26	protease	protease	NN
cord-006860-a3b8hyyr	5004	27	domain	domain	NN
cord-006860-a3b8hyyr	5004	28	is	be	VBZ
cord-006860-a3b8hyyr	5004	29	required	require	VBN
cord-006860-a3b8hyyr	5004	30	.	.	.
cord-006860-a3b8hyyr	5005	1	However	however	RB
cord-006860-a3b8hyyr	5005	2	,	,	,
cord-006860-a3b8hyyr	5005	3	using	use	VBG
cord-006860-a3b8hyyr	5005	4	surface	surface	NN
cord-006860-a3b8hyyr	5005	5	plasrnon	plasrnon	NN
cord-006860-a3b8hyyr	5005	6	resonance	resonance	NN
cord-006860-a3b8hyyr	5005	7	we	-PRON-	PRP
cord-006860-a3b8hyyr	5005	8	have	have	VBP
cord-006860-a3b8hyyr	5005	9	shown	show	VBN
cord-006860-a3b8hyyr	5005	10	that	that	DT
cord-006860-a3b8hyyr	5005	11	removal	removal	NN
cord-006860-a3b8hyyr	5005	12	of	of	IN
cord-006860-a3b8hyyr	5005	13	the	the	DT
cord-006860-a3b8hyyr	5005	14	N	n	CD
cord-006860-a3b8hyyr	5005	15	-	-	HYPH
cord-006860-a3b8hyyr	5005	16	terminal	terminal	NN
cord-006860-a3b8hyyr	5005	17	Gla	Gla	NNP
cord-006860-a3b8hyyr	5005	18	domain	domain	NN
cord-006860-a3b8hyyr	5005	19	and	and	CC
cord-006860-a3b8hyyr	5005	20	hydrophobic	hydrophobic	JJ
cord-006860-a3b8hyyr	5005	21	stack	stack	NN
cord-006860-a3b8hyyr	5005	22	(	(	-LRB-
cord-006860-a3b8hyyr	5005	23	HS	HS	NNP
cord-006860-a3b8hyyr	5005	24	)	)	-RRB-
cord-006860-a3b8hyyr	5005	25	from	from	IN
cord-006860-a3b8hyyr	5005	26	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5005	27	results	result	NNS
cord-006860-a3b8hyyr	5005	28	in	in	IN
cord-006860-a3b8hyyr	5005	29	a	a	DT
cord-006860-a3b8hyyr	5005	30	decreased	decrease	VBN
cord-006860-a3b8hyyr	5005	31	affinity	affinity	NN
cord-006860-a3b8hyyr	5005	32	for	for	IN
cord-006860-a3b8hyyr	5005	33	TF	TF	NNP
cord-006860-a3b8hyyr	5005	34	.	.	.
cord-006860-a3b8hyyr	5006	1	In	in	IN
cord-006860-a3b8hyyr	5006	2	search	search	NN
cord-006860-a3b8hyyr	5006	3	for	for	IN
cord-006860-a3b8hyyr	5006	4	the	the	DT
cord-006860-a3b8hyyr	5006	5	mechanism	mechanism	NN
cord-006860-a3b8hyyr	5006	6	by	by	IN
cord-006860-a3b8hyyr	5006	7	which	which	WDT
cord-006860-a3b8hyyr	5006	8	regions	region	NNS
cord-006860-a3b8hyyr	5006	9	in	in	IN
cord-006860-a3b8hyyr	5006	10	FVUa	FVUa	NNS
cord-006860-a3b8hyyr	5006	11	not	not	RB
cord-006860-a3b8hyyr	5006	12	in	in	IN
cord-006860-a3b8hyyr	5006	13	direct	direct	JJ
cord-006860-a3b8hyyr	5006	14	contact	contact	NN
cord-006860-a3b8hyyr	5006	15	with	with	IN
cord-006860-a3b8hyyr	5006	16	TF	TF	NNP
cord-006860-a3b8hyyr	5006	17	affect	affect	VBP
cord-006860-a3b8hyyr	5006	18	the	the	DT
cord-006860-a3b8hyyr	5006	19	affinity	affinity	NN
cord-006860-a3b8hyyr	5006	20	,	,	,
cord-006860-a3b8hyyr	5006	21	various	various	JJ
cord-006860-a3b8hyyr	5006	22	techniques	technique	NNS
cord-006860-a3b8hyyr	5006	23	have	have	VBP
cord-006860-a3b8hyyr	5006	24	been	be	VBN
cord-006860-a3b8hyyr	5006	25	employed	employ	VBN
cord-006860-a3b8hyyr	5006	26	.	.	.
cord-006860-a3b8hyyr	5007	1	A	a	DT
cord-006860-a3b8hyyr	5007	2	plausible	plausible	JJ
cord-006860-a3b8hyyr	5007	3	model	model	NN
cord-006860-a3b8hyyr	5007	4	is	be	VBZ
cord-006860-a3b8hyyr	5007	5	one	one	CD
cord-006860-a3b8hyyr	5007	6	in	in	IN
cord-006860-a3b8hyyr	5007	7	which	which	WDT
cord-006860-a3b8hyyr	5007	8	the	the	DT
cord-006860-a3b8hyyr	5007	9	Gla	Gla	NNP
cord-006860-a3b8hyyr	5007	10	domain	domain	NN
cord-006860-a3b8hyyr	5007	11	and	and	CC
cord-006860-a3b8hyyr	5007	12	HS	HS	NNP
cord-006860-a3b8hyyr	5007	13	optimize	optimize	VBP
cord-006860-a3b8hyyr	5007	14	the	the	DT
cord-006860-a3b8hyyr	5007	15	interaction	interaction	NN
cord-006860-a3b8hyyr	5007	16	with	with	IN
cord-006860-a3b8hyyr	5007	17	TF	TF	NNP
cord-006860-a3b8hyyr	5007	18	by	by	IN
cord-006860-a3b8hyyr	5007	19	affecting	affect	VBG
cord-006860-a3b8hyyr	5007	20	regions	region	NNS
cord-006860-a3b8hyyr	5007	21	that	that	WDT
cord-006860-a3b8hyyr	5007	22	mediate	mediate	VBP
cord-006860-a3b8hyyr	5007	23	the	the	DT
cord-006860-a3b8hyyr	5007	24	association	association	NN
cord-006860-a3b8hyyr	5007	25	with	with	IN
cord-006860-a3b8hyyr	5007	26	TF	TF	NNP
cord-006860-a3b8hyyr	5007	27	.	.	.
cord-006860-a3b8hyyr	5008	1	Using	use	VBG
cord-006860-a3b8hyyr	5008	2	gel	gel	NN
cord-006860-a3b8hyyr	5008	3	filtration	filtration	NN
cord-006860-a3b8hyyr	5008	4	we	-PRON-	PRP
cord-006860-a3b8hyyr	5008	5	demonstrated	demonstrate	VBD
cord-006860-a3b8hyyr	5008	6	that	that	IN
cord-006860-a3b8hyyr	5008	7	the	the	DT
cord-006860-a3b8hyyr	5008	8	hydrodynamic	hydrodynamic	JJ
cord-006860-a3b8hyyr	5008	9	radii	radius	NNS
cord-006860-a3b8hyyr	5008	10	of	of	IN
cord-006860-a3b8hyyr	5008	11	des(1	des(1	NN
cord-006860-a3b8hyyr	5008	12	-	-	HYPH
cord-006860-a3b8hyyr	5008	13	38)-FVIIa	38)-FVIIa	NNS
cord-006860-a3b8hyyr	5008	14	and	and	CC
cord-006860-a3b8hyyr	5008	15	,	,	,
cord-006860-a3b8hyyr	5008	16	especially	especially	RB
cord-006860-a3b8hyyr	5008	17	,	,	,
cord-006860-a3b8hyyr	5008	18	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5008	19	decreased	decrease	VBD
cord-006860-a3b8hyyr	5008	20	upon	upon	IN
cord-006860-a3b8hyyr	5008	21	Ca2	ca2	CD
cord-006860-a3b8hyyr	5008	22	+	+	CC
cord-006860-a3b8hyyr	5008	23	binding	binding	NN
cord-006860-a3b8hyyr	5008	24	,	,	,
cord-006860-a3b8hyyr	5008	25	whereas	whereas	IN
cord-006860-a3b8hyyr	5008	26	des(1	des(1	NNP
cord-006860-a3b8hyyr	5008	27	-	-	HYPH
cord-006860-a3b8hyyr	5008	28	44)-FVIIa	44)-FVIIa	NNP
cord-006860-a3b8hyyr	5008	29	was	be	VBD
cord-006860-a3b8hyyr	5008	30	virtually	virtually	RB
cord-006860-a3b8hyyr	5008	31	unaffected	unaffected	JJ
cord-006860-a3b8hyyr	5008	32	.	.	.
cord-006860-a3b8hyyr	5009	1	This	this	DT
cord-006860-a3b8hyyr	5009	2	suggested	suggest	VBD
cord-006860-a3b8hyyr	5009	3	that	that	IN
cord-006860-a3b8hyyr	5009	4	the	the	DT
cord-006860-a3b8hyyr	5009	5	Gla	Gla	NNP
cord-006860-a3b8hyyr	5009	6	domain	domain	NN
cord-006860-a3b8hyyr	5009	7	and	and	CC
cord-006860-a3b8hyyr	5009	8	the	the	DT
cord-006860-a3b8hyyr	5009	9	HS	HS	NNP
cord-006860-a3b8hyyr	5009	10	interact	interact	VBP
cord-006860-a3b8hyyr	5009	11	in	in	IN
cord-006860-a3b8hyyr	5009	12	a	a	DT
cord-006860-a3b8hyyr	5009	13	Ca2	ca2	NN
cord-006860-a3b8hyyr	5009	14	+	+	CC
cord-006860-a3b8hyyr	5010	1	-dependent	-dependent	JJ
cord-006860-a3b8hyyr	5010	2	manner	manner	NN
cord-006860-a3b8hyyr	5010	3	with	with	IN
cord-006860-a3b8hyyr	5010	4	other	other	JJ
cord-006860-a3b8hyyr	5010	5	regions	region	NNS
cord-006860-a3b8hyyr	5010	6	in	in	IN
cord-006860-a3b8hyyr	5010	7	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5010	8	,	,	,
cord-006860-a3b8hyyr	5010	9	presumably	presumably	RB
cord-006860-a3b8hyyr	5010	10	the	the	DT
cord-006860-a3b8hyyr	5010	11	protease	protease	NN
cord-006860-a3b8hyyr	5010	12	domain	domain	NN
cord-006860-a3b8hyyr	5010	13	,	,	,
cord-006860-a3b8hyyr	5011	1	making	make	VBG
cord-006860-a3b8hyyr	5011	2	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5011	3	more	more	RBR
cord-006860-a3b8hyyr	5011	4	globular	globular	JJ
cord-006860-a3b8hyyr	5011	5	.	.	.
cord-006860-a3b8hyyr	5012	1	Using	use	VBG
cord-006860-a3b8hyyr	5012	2	CD	cd	NN
cord-006860-a3b8hyyr	5012	3	spectroscopy	spectroscopy	NN
cord-006860-a3b8hyyr	5012	4	,	,	,
cord-006860-a3b8hyyr	5012	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	5012	6	could	could	MD
cord-006860-a3b8hyyr	5012	7	detect	detect	VB
cord-006860-a3b8hyyr	5012	8	Ca2	ca2	CD
cord-006860-a3b8hyyr	5012	9	+	+	SYM
cord-006860-a3b8hyyr	5012	10	-induced	-induce	VBN
cord-006860-a3b8hyyr	5012	11	changes	change	NNS
cord-006860-a3b8hyyr	5012	12	in	in	IN
cord-006860-a3b8hyyr	5012	13	the	the	DT
cord-006860-a3b8hyyr	5012	14	secondary	secondary	JJ
cord-006860-a3b8hyyr	5012	15	structure	structure	NN
cord-006860-a3b8hyyr	5012	16	of	of	IN
cord-006860-a3b8hyyr	5012	17	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5012	18	,	,	,
cord-006860-a3b8hyyr	5012	19	all	all	DT
cord-006860-a3b8hyyr	5012	20	assignable	assignable	JJ
cord-006860-a3b8hyyr	5012	21	to	to	IN
cord-006860-a3b8hyyr	5012	22	an	an	DT
cord-006860-a3b8hyyr	5012	23	increased	increase	VBN
cord-006860-a3b8hyyr	5012	24	helical	helical	JJ
cord-006860-a3b8hyyr	5012	25	content	content	NN
cord-006860-a3b8hyyr	5012	26	of	of	IN
cord-006860-a3b8hyyr	5012	27	the	the	DT
cord-006860-a3b8hyyr	5012	28	Gla	Gla	NNP
cord-006860-a3b8hyyr	5012	29	domain	domain	NN
cord-006860-a3b8hyyr	5012	30	.	.	.
cord-006860-a3b8hyyr	5013	1	The	the	DT
cord-006860-a3b8hyyr	5013	2	amidolytic	amidolytic	JJ
cord-006860-a3b8hyyr	5013	3	activity	activity	NN
cord-006860-a3b8hyyr	5013	4	of	of	IN
cord-006860-a3b8hyyr	5013	5	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5013	6	in	in	IN
cord-006860-a3b8hyyr	5013	7	the	the	DT
cord-006860-a3b8hyyr	5013	8	absence	absence	NN
cord-006860-a3b8hyyr	5013	9	of	of	IN
cord-006860-a3b8hyyr	5013	10	TF	TF	NNP
cord-006860-a3b8hyyr	5013	11	has	have	VBZ
cord-006860-a3b8hyyr	5013	12	a	a	DT
cord-006860-a3b8hyyr	5013	13	Ca2	ca2	CD
cord-006860-a3b8hyyr	5013	14	+	+	CC
cord-006860-a3b8hyyr	5013	15	dependency	dependency	NN
cord-006860-a3b8hyyr	5013	16	that	that	WDT
cord-006860-a3b8hyyr	5013	17	suggests	suggest	VBZ
cord-006860-a3b8hyyr	5013	18	involvement	involvement	NN
cord-006860-a3b8hyyr	5013	19	of	of	IN
cord-006860-a3b8hyyr	5013	20	the	the	DT
cord-006860-a3b8hyyr	5013	21	Gla	Gla	NNP
cord-006860-a3b8hyyr	5013	22	domain	domain	NN
cord-006860-a3b8hyyr	5013	23	in	in	IN
cord-006860-a3b8hyyr	5013	24	obtaining	obtain	VBG
cord-006860-a3b8hyyr	5013	25	full	full	JJ
cord-006860-a3b8hyyr	5013	26	activity	activity	NN
cord-006860-a3b8hyyr	5013	27	.	.	.
cord-006860-a3b8hyyr	5014	1	This	this	DT
cord-006860-a3b8hyyr	5014	2	activity	activity	NN
cord-006860-a3b8hyyr	5014	3	was	be	VBD
cord-006860-a3b8hyyr	5014	4	very	very	RB
cord-006860-a3b8hyyr	5014	5	sensitive	sensitive	JJ
cord-006860-a3b8hyyr	5014	6	to	to	IN
cord-006860-a3b8hyyr	5014	7	guanidine	guanidine	FW
cord-006860-a3b8hyyr	5014	8	hydrochloride	hydrochloride	NN
cord-006860-a3b8hyyr	5014	9	(	(	-LRB-
cord-006860-a3b8hyyr	5014	10	C50<0.5	C50<0.5	NNP
cord-006860-a3b8hyyr	5014	11	M	M	NNP
cord-006860-a3b8hyyr	5014	12	)	)	-RRB-
cord-006860-a3b8hyyr	5014	13	and	and	CC
cord-006860-a3b8hyyr	5014	14	its	-PRON-	PRP$
cord-006860-a3b8hyyr	5014	15	quenching	quenching	NN
cord-006860-a3b8hyyr	5014	16	corresponded	correspond	VBD
cord-006860-a3b8hyyr	5014	17	to	to	IN
cord-006860-a3b8hyyr	5014	18	unfolding	unfold	VBG
cord-006860-a3b8hyyr	5014	19	of	of	IN
cord-006860-a3b8hyyr	5014	20	the	the	DT
cord-006860-a3b8hyyr	5014	21	Ca2	ca2	CD
cord-006860-a3b8hyyr	5014	22	+	+	SYM
cord-006860-a3b8hyyr	5014	23	-loaded	-loaded	CD
cord-006860-a3b8hyyr	5014	24	Gla	Gla	NNP
cord-006860-a3b8hyyr	5014	25	domain	domain	NN
cord-006860-a3b8hyyr	5014	26	as	as	IN
cord-006860-a3b8hyyr	5014	27	measured	measure	VBN
cord-006860-a3b8hyyr	5014	28	by	by	IN
cord-006860-a3b8hyyr	5014	29	changes	change	NNS
cord-006860-a3b8hyyr	5014	30	in	in	IN
cord-006860-a3b8hyyr	5014	31	the	the	DT
cord-006860-a3b8hyyr	5014	32	Trp	trp	NN
cord-006860-a3b8hyyr	5014	33	fluorescence	fluorescence	NN
cord-006860-a3b8hyyr	5014	34	of	of	IN
cord-006860-a3b8hyyr	5014	35	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5014	36	.	.	.
cord-006860-a3b8hyyr	5015	1	Based	base	VBN
cord-006860-a3b8hyyr	5015	2	on	on	IN
cord-006860-a3b8hyyr	5015	3	these	these	DT
cord-006860-a3b8hyyr	5015	4	results	result	NNS
cord-006860-a3b8hyyr	5015	5	it	-PRON-	PRP
cord-006860-a3b8hyyr	5015	6	is	be	VBZ
cord-006860-a3b8hyyr	5015	7	conceivable	conceivable	JJ
cord-006860-a3b8hyyr	5015	8	that	that	IN
cord-006860-a3b8hyyr	5015	9	the	the	DT
cord-006860-a3b8hyyr	5015	10	Gla	Gla	NNP
cord-006860-a3b8hyyr	5015	11	domain	domain	NN
cord-006860-a3b8hyyr	5015	12	and	and	CC
cord-006860-a3b8hyyr	5015	13	perhaps	perhaps	RB
cord-006860-a3b8hyyr	5015	14	the	the	DT
cord-006860-a3b8hyyr	5015	15	HS	hs	NN
cord-006860-a3b8hyyr	5015	16	of	of	IN
cord-006860-a3b8hyyr	5015	17	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5015	18	interacts	interact	VBZ
cord-006860-a3b8hyyr	5015	19	with	with	IN
cord-006860-a3b8hyyr	5015	20	the	the	DT
cord-006860-a3b8hyyr	5015	21	protease	protease	NN
cord-006860-a3b8hyyr	5015	22	domain	domain	NN
cord-006860-a3b8hyyr	5015	23	and	and	CC
cord-006860-a3b8hyyr	5015	24	that	that	IN
cord-006860-a3b8hyyr	5015	25	this	this	DT
cord-006860-a3b8hyyr	5015	26	globular	globular	JJ
cord-006860-a3b8hyyr	5015	27	form	form	NN
cord-006860-a3b8hyyr	5015	28	mediates	mediate	VBZ
cord-006860-a3b8hyyr	5015	29	the	the	DT
cord-006860-a3b8hyyr	5015	30	initial	initial	JJ
cord-006860-a3b8hyyr	5015	31	contact	contact	NN
cord-006860-a3b8hyyr	5015	32	with	with	IN
cord-006860-a3b8hyyr	5015	33	"	"	``
cord-006860-a3b8hyyr	5015	34	IT	it	NN
cord-006860-a3b8hyyr	5015	35	.	.	.
cord-006860-a3b8hyyr	5016	1	Several	several	JJ
cord-006860-a3b8hyyr	5016	2	studies	study	NNS
cord-006860-a3b8hyyr	5016	3	have	have	VBP
cord-006860-a3b8hyyr	5016	4	indicated	indicate	VBN
cord-006860-a3b8hyyr	5016	5	a	a	DT
cord-006860-a3b8hyyr	5016	6	profound	profound	JJ
cord-006860-a3b8hyyr	5016	7	role	role	NN
cord-006860-a3b8hyyr	5016	8	for	for	IN
cord-006860-a3b8hyyr	5016	9	FVII(a	fvii(a	NN
cord-006860-a3b8hyyr	5016	10	)	)	-RRB-
cord-006860-a3b8hyyr	5016	11	in	in	IN
cord-006860-a3b8hyyr	5016	12	arterial	arterial	JJ
cord-006860-a3b8hyyr	5016	13	thrombogenesis	thrombogenesis	NN
cord-006860-a3b8hyyr	5016	14	.	.	.
cord-006860-a3b8hyyr	5017	1	In	in	IN
cord-006860-a3b8hyyr	5017	2	the	the	DT
cord-006860-a3b8hyyr	5017	3	present	present	JJ
cord-006860-a3b8hyyr	5017	4	study	study	NN
cord-006860-a3b8hyyr	5017	5	we	-PRON-	PRP
cord-006860-a3b8hyyr	5017	6	quantified	quantify	VBD
cord-006860-a3b8hyyr	5017	7	the	the	DT
cord-006860-a3b8hyyr	5017	8	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	5017	9	effect	effect	NN
cord-006860-a3b8hyyr	5017	10	of	of	IN
cord-006860-a3b8hyyr	5017	11	dansyl	dansyl	NN
cord-006860-a3b8hyyr	5017	12	-	-	HYPH
cord-006860-a3b8hyyr	5017	13	glutamyl	glutamyl	NN
cord-006860-a3b8hyyr	5017	14	-	-	HYPH
cord-006860-a3b8hyyr	5017	15	glycyl	glycyl	NNP
cord-006860-a3b8hyyr	5017	16	-	-	HYPH
cord-006860-a3b8hyyr	5017	17	arginyl	arginyl	NN
cord-006860-a3b8hyyr	5017	18	-	-	HYPH
cord-006860-a3b8hyyr	5017	19	chloromethyl	chloromethyl	NN
cord-006860-a3b8hyyr	5017	20	ketone	ketone	NN
cord-006860-a3b8hyyr	5017	21	recombinant	recombinant	NN
cord-006860-a3b8hyyr	5017	22	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5017	23	(	(	-LRB-
cord-006860-a3b8hyyr	5017	24	DEGR	DEGR	NNP
cord-006860-a3b8hyyr	5017	25	-	-	HYPH
cord-006860-a3b8hyyr	5017	26	rFVIIa	rfviia	NN
cord-006860-a3b8hyyr	5017	27	)	)	-RRB-
cord-006860-a3b8hyyr	5017	28	on	on	IN
cord-006860-a3b8hyyr	5017	29	acute	acute	JJ
cord-006860-a3b8hyyr	5017	30	thrombus	thrombus	NN
cord-006860-a3b8hyyr	5017	31	formation	formation	NN
cord-006860-a3b8hyyr	5017	32	at	at	IN
cord-006860-a3b8hyyr	5017	33	medium	medium	JJ
cord-006860-a3b8hyyr	5017	34	-	-	HYPH
cord-006860-a3b8hyyr	5017	35	sized	sized	JJ
cord-006860-a3b8hyyr	5017	36	artery	artery	NN
cord-006860-a3b8hyyr	5017	37	blood	blood	NN
cord-006860-a3b8hyyr	5017	38	flow	flow	NN
cord-006860-a3b8hyyr	5017	39	conditions	condition	NNS
cord-006860-a3b8hyyr	5017	40	characterized	characterize	VBN
cord-006860-a3b8hyyr	5017	41	by	by	IN
cord-006860-a3b8hyyr	5017	42	a	a	DT
cord-006860-a3b8hyyr	5017	43	wall	wall	NN
cord-006860-a3b8hyyr	5017	44	shear	shear	NN
cord-006860-a3b8hyyr	5017	45	rate	rate	NN
cord-006860-a3b8hyyr	5017	46	of	of	IN
cord-006860-a3b8hyyr	5017	47	650	650	CD
cord-006860-a3b8hyyr	5017	48	s	s	NN
cord-006860-a3b8hyyr	5017	49	-1	-1	NN
cord-006860-a3b8hyyr	5017	50	.	.	.
cord-006860-a3b8hyyr	5018	1	Native	native	JJ
cord-006860-a3b8hyyr	5018	2	human	human	JJ
cord-006860-a3b8hyyr	5018	3	blood	blood	NN
cord-006860-a3b8hyyr	5018	4	was	be	VBD
cord-006860-a3b8hyyr	5018	5	drawn	draw	VBN
cord-006860-a3b8hyyr	5018	6	directly	directly	RB
cord-006860-a3b8hyyr	5018	7	from	from	IN
cord-006860-a3b8hyyr	5018	8	an	an	DT
cord-006860-a3b8hyyr	5018	9	antecubital	antecubital	JJ
cord-006860-a3b8hyyr	5018	10	vein	vein	NN
cord-006860-a3b8hyyr	5018	11	by	by	IN
cord-006860-a3b8hyyr	5018	12	a	a	DT
cord-006860-a3b8hyyr	5018	13	pump	pump	NN
cord-006860-a3b8hyyr	5018	14	into	into	IN
cord-006860-a3b8hyyr	5018	15	a	a	DT
cord-006860-a3b8hyyr	5018	16	heparin	heparin	NN
cord-006860-a3b8hyyr	5018	17	coated	coat	VBN
cord-006860-a3b8hyyr	5018	18	mixing	mix	VBG
cord-006860-a3b8hyyr	5018	19	device	device	NN
cord-006860-a3b8hyyr	5018	20	where	where	WRB
cord-006860-a3b8hyyr	5018	21	DEGR	DEGR	NNP
cord-006860-a3b8hyyr	5018	22	-	-	HYPH
cord-006860-a3b8hyyr	5018	23	rFVIIa	rfviia	NN
cord-006860-a3b8hyyr	5018	24	(	(	-LRB-
cord-006860-a3b8hyyr	5018	25	0.9	0.9	CD
cord-006860-a3b8hyyr	5018	26	-880	-880	NNP
cord-006860-a3b8hyyr	5018	27	nmol	nmol	NNP
cord-006860-a3b8hyyr	5018	28	/	/	SYM
cord-006860-a3b8hyyr	5018	29	L	L	NNP
cord-006860-a3b8hyyr	5018	30	final	final	JJ
cord-006860-a3b8hyyr	5018	31	plasma	plasma	NN
cord-006860-a3b8hyyr	5018	32	concentration	concentration	NN
cord-006860-a3b8hyyr	5018	33	)	)	-RRB-
cord-006860-a3b8hyyr	5018	34	or	or	CC
cord-006860-a3b8hyyr	5018	35	buffer	buffer	NN
cord-006860-a3b8hyyr	5018	36	were	be	VBD
cord-006860-a3b8hyyr	5018	37	mixed	mix	VBN
cord-006860-a3b8hyyr	5018	38	homogeneously	homogeneously	RB
cord-006860-a3b8hyyr	5018	39	with	with	IN
cord-006860-a3b8hyyr	5018	40	the	the	DT
cord-006860-a3b8hyyr	5018	41	flowing	flow	VBG
cord-006860-a3b8hyyr	5018	42	blood	blood	NN
cord-006860-a3b8hyyr	5018	43	.	.	.
cord-006860-a3b8hyyr	5019	1	Subsequently	subsequently	RB
cord-006860-a3b8hyyr	5019	2	,	,	,
cord-006860-a3b8hyyr	5019	3	the	the	DT
cord-006860-a3b8hyyr	5019	4	blood	blood	NN
cord-006860-a3b8hyyr	5019	5	entered	enter	VBD
cord-006860-a3b8hyyr	5019	6	a	a	DT
cord-006860-a3b8hyyr	5019	7	parallel	parallel	JJ
cord-006860-a3b8hyyr	5019	8	-	-	HYPH
cord-006860-a3b8hyyr	5019	9	plate	plate	NN
cord-006860-a3b8hyyr	5019	10	perfusion	perfusion	NN
cord-006860-a3b8hyyr	5019	11	chamber	chamber	NN
cord-006860-a3b8hyyr	5019	12	in	in	IN
cord-006860-a3b8hyyr	5019	13	which	which	WDT
cord-006860-a3b8hyyr	5019	14	a	a	DT
cord-006860-a3b8hyyr	5019	15	thrombogenic	thrombogenic	JJ
cord-006860-a3b8hyyr	5019	16	surface	surface	NN
cord-006860-a3b8hyyr	5019	17	consisting	consist	VBG
cord-006860-a3b8hyyr	5019	18	of	of	IN
cord-006860-a3b8hyyr	5019	19	immobilized	immobilize	VBN
cord-006860-a3b8hyyr	5019	20	TF	TF	NNP
cord-006860-a3b8hyyr	5019	21	and	and	CC
cord-006860-a3b8hyyr	5019	22	phospholipids	phospholipid	NNS
cord-006860-a3b8hyyr	5019	23	was	be	VBD
cord-006860-a3b8hyyr	5019	24	positioned	position	VBN
cord-006860-a3b8hyyr	5019	25	.	.	.
cord-006860-a3b8hyyr	5020	1	Fibrin	fibrin	NN
cord-006860-a3b8hyyr	5020	2	deposition	deposition	NN
cord-006860-a3b8hyyr	5020	3	,	,	,
cord-006860-a3b8hyyr	5020	4	platelet	platelet	NN
cord-006860-a3b8hyyr	5020	5	-	-	HYPH
cord-006860-a3b8hyyr	5020	6	fibrin	fibrin	NN
cord-006860-a3b8hyyr	5020	7	adhesion	adhesion	NN
cord-006860-a3b8hyyr	5020	8	and	and	CC
cord-006860-a3b8hyyr	5020	9	platetet	platetet	NNP
cord-006860-a3b8hyyr	5020	10	thrombus	thrombus	NN
cord-006860-a3b8hyyr	5020	11	volume	volume	NN
cord-006860-a3b8hyyr	5020	12	triggered	trigger	VBN
cord-006860-a3b8hyyr	5020	13	by	by	IN
cord-006860-a3b8hyyr	5020	14	this	this	DT
cord-006860-a3b8hyyr	5020	15	surface	surface	NN
cord-006860-a3b8hyyr	5020	16	were	be	VBD
cord-006860-a3b8hyyr	5020	17	measured	measure	VBN
cord-006860-a3b8hyyr	5020	18	by	by	IN
cord-006860-a3b8hyyr	5020	19	morphometry	morphometry	NNP
cord-006860-a3b8hyyr	5020	20	.	.	.
cord-006860-a3b8hyyr	5021	1	DEGR	DEGR	NNP
cord-006860-a3b8hyyr	5021	2	-	-	HYPH
cord-006860-a3b8hyyr	5021	3	rFVIIa	rfviia	NN
cord-006860-a3b8hyyr	5021	4	inhibited	inhibit	VBD
cord-006860-a3b8hyyr	5021	5	these	these	DT
cord-006860-a3b8hyyr	5021	6	thrombus	thrombus	NN
cord-006860-a3b8hyyr	5021	7	parameters	parameter	NNS
cord-006860-a3b8hyyr	5021	8	in	in	IN
cord-006860-a3b8hyyr	5021	9	a	a	DT
cord-006860-a3b8hyyr	5021	10	dose	dose	NN
cord-006860-a3b8hyyr	5021	11	dependent	dependent	JJ
cord-006860-a3b8hyyr	5021	12	manner	manner	NN
cord-006860-a3b8hyyr	5021	13	with	with	IN
cord-006860-a3b8hyyr	5021	14	IC50	ic50	JJ
cord-006860-a3b8hyyr	5021	15	values	value	NNS
cord-006860-a3b8hyyr	5021	16	between	between	IN
cord-006860-a3b8hyyr	5021	17	0.5	0.5	CD
cord-006860-a3b8hyyr	5021	18	and	and	CC
cord-006860-a3b8hyyr	5021	19	0.7	0.7	CD
cord-006860-a3b8hyyr	5021	20	nmol	nmol	NN
cord-006860-a3b8hyyr	5021	21	/	/	SYM
cord-006860-a3b8hyyr	5021	22	L	l	NN
cord-006860-a3b8hyyr	5022	1	The	the	DT
cord-006860-a3b8hyyr	5022	2	plasma	plasma	NN
cord-006860-a3b8hyyr	5022	3	levels	level	NNS
cord-006860-a3b8hyyr	5022	4	of	of	IN
cord-006860-a3b8hyyr	5022	5	thrombin	thrombin	NN
cord-006860-a3b8hyyr	5022	6	-	-	HYPH
cord-006860-a3b8hyyr	5022	7	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	5022	8	m	m	CD
cord-006860-a3b8hyyr	5022	9	complexes	complex	NNS
cord-006860-a3b8hyyr	5022	10	were	be	VBD
cord-006860-a3b8hyyr	5022	11	inhibited	inhibit	VBN
cord-006860-a3b8hyyr	5022	12	at	at	IN
cord-006860-a3b8hyyr	5022	13	an	an	DT
cord-006860-a3b8hyyr	5022	14	IC50	IC50	NNP
cord-006860-a3b8hyyr	5022	15	of	of	IN
cord-006860-a3b8hyyr	5022	16	0.6	0.6	CD
cord-006860-a3b8hyyr	5022	17	nmot	nmot	NNPS
cord-006860-a3b8hyyr	5022	18	/	/	SYM
cord-006860-a3b8hyyr	5022	19	L	l	NN
cord-006860-a3b8hyyr	5022	20	Since	since	IN
cord-006860-a3b8hyyr	5022	21	the	the	DT
cord-006860-a3b8hyyr	5022	22	concentration	concentration	NN
cord-006860-a3b8hyyr	5022	23	of	of	IN
cord-006860-a3b8hyyr	5022	24	FVII	FVII	NNP
cord-006860-a3b8hyyr	5022	25	and	and	CC
cord-006860-a3b8hyyr	5022	26	FVIIa	FVIIa	NNS
cord-006860-a3b8hyyr	5022	27	in	in	IN
cord-006860-a3b8hyyr	5022	28	normal	normal	JJ
cord-006860-a3b8hyyr	5022	29	plasma	plasma	NN
cord-006860-a3b8hyyr	5022	30	is	be	VBZ
cord-006860-a3b8hyyr	5022	31	about	about	RB
cord-006860-a3b8hyyr	5022	32	10	10	CD
cord-006860-a3b8hyyr	5022	33	and	and	CC
cord-006860-a3b8hyyr	5022	34	0.1	0.1	CD
cord-006860-a3b8hyyr	5022	35	nmol	nmol	JJ
cord-006860-a3b8hyyr	5022	36	/	/	SYM
cord-006860-a3b8hyyr	5022	37	L	L	NNP
cord-006860-a3b8hyyr	5022	38	,	,	,
cord-006860-a3b8hyyr	5022	39	respectively	respectively	RB
cord-006860-a3b8hyyr	5022	40	,	,	,
cord-006860-a3b8hyyr	5022	41	theIC50	theIC50	NNP
cord-006860-a3b8hyyr	5022	42	values	value	NNS
cord-006860-a3b8hyyr	5022	43	indicate	indicate	VBP
cord-006860-a3b8hyyr	5022	44	that	that	IN
cord-006860-a3b8hyyr	5022	45	DEGR	DEGR	NNP
cord-006860-a3b8hyyr	5022	46	-	-	HYPH
cord-006860-a3b8hyyr	5022	47	rFVIIa	rfviia	NN
cord-006860-a3b8hyyr	5022	48	is	be	VBZ
cord-006860-a3b8hyyr	5022	49	a	a	DT
cord-006860-a3b8hyyr	5022	50	very	very	RB
cord-006860-a3b8hyyr	5022	51	efficient	efficient	JJ
cord-006860-a3b8hyyr	5022	52	inhibitor	inhibitor	NN
cord-006860-a3b8hyyr	5022	53	of	of	IN
cord-006860-a3b8hyyr	5022	54	thrombus	thrombus	NN
cord-006860-a3b8hyyr	5022	55	formation	formation	NN
cord-006860-a3b8hyyr	5022	56	in	in	IN
cord-006860-a3b8hyyr	5022	57	this	this	DT
cord-006860-a3b8hyyr	5022	58	model	model	NN
cord-006860-a3b8hyyr	5022	59	.	.	.
cord-006860-a3b8hyyr	5023	1	Thus	thus	RB
cord-006860-a3b8hyyr	5023	2	,	,	,
cord-006860-a3b8hyyr	5023	3	inhibition	inhibition	NN
cord-006860-a3b8hyyr	5023	4	of	of	IN
cord-006860-a3b8hyyr	5023	5	the	the	DT
cord-006860-a3b8hyyr	5023	6	extrinsic	extrinsic	JJ
cord-006860-a3b8hyyr	5023	7	pathway	pathway	NN
cord-006860-a3b8hyyr	5023	8	of	of	IN
cord-006860-a3b8hyyr	5023	9	coagulation	coagulation	NN
cord-006860-a3b8hyyr	5023	10	may	may	MD
cord-006860-a3b8hyyr	5023	11	represent	represent	VB
cord-006860-a3b8hyyr	5023	12	and	and	CC
cord-006860-a3b8hyyr	5023	13	entirely	entirely	RB
cord-006860-a3b8hyyr	5023	14	new	new	JJ
cord-006860-a3b8hyyr	5023	15	and	and	CC
cord-006860-a3b8hyyr	5023	16	effective	effective	JJ
cord-006860-a3b8hyyr	5023	17	arterial	arterial	JJ
cord-006860-a3b8hyyr	5023	18	anti	anti	JJ
cord-006860-a3b8hyyr	5023	19	-	-	JJ
cord-006860-a3b8hyyr	5023	20	thrombotic	thrombotic	JJ
cord-006860-a3b8hyyr	5023	21	approach	approach	NN
cord-006860-a3b8hyyr	5023	22	.	.	.
cord-006860-a3b8hyyr	5024	1	The	the	DT
cord-006860-a3b8hyyr	5024	2	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	5024	3	agent	agent	NN
cord-006860-a3b8hyyr	5024	4	from	from	IN
cord-006860-a3b8hyyr	5024	5	medicinal	medicinal	JJ
cord-006860-a3b8hyyr	5024	6	leeches	leech	NNS
cord-006860-a3b8hyyr	5024	7	,	,	,
cord-006860-a3b8hyyr	5024	8	hirudin	hirudin	NN
cord-006860-a3b8hyyr	5024	9	,	,	,
cord-006860-a3b8hyyr	5024	10	is	be	VBZ
cord-006860-a3b8hyyr	5024	11	presently	presently	RB
cord-006860-a3b8hyyr	5024	12	gaining	gain	VBG
cord-006860-a3b8hyyr	5024	13	popularity	popularity	NN
cord-006860-a3b8hyyr	5024	14	as	as	IN
cord-006860-a3b8hyyr	5024	15	an	an	DT
cord-006860-a3b8hyyr	5024	16	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	5024	17	drug	drug	NN
cord-006860-a3b8hyyr	5024	18	.	.	.
cord-006860-a3b8hyyr	5025	1	The	the	DT
cord-006860-a3b8hyyr	5025	2	design	design	NN
cord-006860-a3b8hyyr	5025	3	of	of	IN
cord-006860-a3b8hyyr	5025	4	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	5025	5	forms	form	NNS
cord-006860-a3b8hyyr	5025	6	of	of	IN
cord-006860-a3b8hyyr	5025	7	the	the	DT
cord-006860-a3b8hyyr	5025	8	minipretein	minipretein	NNP
cord-006860-a3b8hyyr	5025	9	and	and	CC
cord-006860-a3b8hyyr	5025	10	their	-PRON-	PRP$
cord-006860-a3b8hyyr	5025	11	availability	availability	NN
cord-006860-a3b8hyyr	5025	12	led	lead	VBD
cord-006860-a3b8hyyr	5025	13	to	to	IN
cord-006860-a3b8hyyr	5025	14	the	the	DT
cord-006860-a3b8hyyr	5025	15	clinical	clinical	JJ
cord-006860-a3b8hyyr	5025	16	use	use	NN
cord-006860-a3b8hyyr	5025	17	of	of	IN
cord-006860-a3b8hyyr	5025	18	this	this	DT
cord-006860-a3b8hyyr	5025	19	naturally	naturally	RB
cord-006860-a3b8hyyr	5025	20	occurring	occur	VBG
cord-006860-a3b8hyyr	5025	21	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	5025	22	Inhibitor	Inhibitor	NNP
cord-006860-a3b8hyyr	5025	23	.	.	.
cord-006860-a3b8hyyr	5026	1	Extensive	extensive	JJ
cord-006860-a3b8hyyr	5026	2	studies	study	NNS
cord-006860-a3b8hyyr	5026	3	in	in	IN
cord-006860-a3b8hyyr	5026	4	experimental	experimental	JJ
cord-006860-a3b8hyyr	5026	5	animals	animal	NNS
cord-006860-a3b8hyyr	5026	6	have	have	VBP
cord-006860-a3b8hyyr	5026	7	shown	show	VBN
cord-006860-a3b8hyyr	5026	8	that	that	IN
cord-006860-a3b8hyyr	5026	9	due	due	IN
cord-006860-a3b8hyyr	5026	10	to	to	IN
cord-006860-a3b8hyyr	5026	11	its	-PRON-	PRP$
cord-006860-a3b8hyyr	5026	12	pronounced	pronounced	JJ
cord-006860-a3b8hyyr	5026	13	and	and	CC
cord-006860-a3b8hyyr	5026	14	specific	specific	JJ
cord-006860-a3b8hyyr	5026	15	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	5026	16	effect	effect	NN
cord-006860-a3b8hyyr	5026	17	hirudin	hirudin	NN
cord-006860-a3b8hyyr	5026	18	is	be	VBZ
cord-006860-a3b8hyyr	5026	19	an	an	DT
cord-006860-a3b8hyyr	5026	20	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	5026	21	agent	agent	NN
cord-006860-a3b8hyyr	5026	22	of	of	IN
cord-006860-a3b8hyyr	5026	23	high	high	JJ
cord-006860-a3b8hyyr	5026	24	quality	quality	NN
cord-006860-a3b8hyyr	5026	25	.	.	.
cord-006860-a3b8hyyr	5027	1	Apart	apart	RB
cord-006860-a3b8hyyr	5027	2	from	from	IN
cord-006860-a3b8hyyr	5027	3	its	-PRON-	PRP$
cord-006860-a3b8hyyr	5027	4	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	5027	5	effect	effect	NN
cord-006860-a3b8hyyr	5027	6	,	,	,
cord-006860-a3b8hyyr	5027	7	hirudin	hirudin	NN
cord-006860-a3b8hyyr	5027	8	is	be	VBZ
cord-006860-a3b8hyyr	5027	9	pharmacodynamically	pharmacodynamically	RB
cord-006860-a3b8hyyr	5027	10	inert	inert	JJ
cord-006860-a3b8hyyr	5027	11	and	and	CC
cord-006860-a3b8hyyr	5027	12	is	be	VBZ
cord-006860-a3b8hyyr	5027	13	well	well	RB
cord-006860-a3b8hyyr	5027	14	tolerated	tolerate	VBN
cord-006860-a3b8hyyr	5027	15	in	in	IN
cord-006860-a3b8hyyr	5027	16	vivo	vivo	NNP
cord-006860-a3b8hyyr	5027	17	.	.	.
cord-006860-a3b8hyyr	5027	18	 	 	_SP
cord-006860-a3b8hyyr	5028	1	Brain	brain	NN
cord-006860-a3b8hyyr	5028	2	abnormalities	abnormality	NNS
cord-006860-a3b8hyyr	5028	3	in	in	IN
cord-006860-a3b8hyyr	5028	4	male	male	JJ
cord-006860-a3b8hyyr	5028	5	children	child	NNS
cord-006860-a3b8hyyr	5028	6	and	and	CC
cord-006860-a3b8hyyr	5028	7	adoleescents	adoleescent	NNS
cord-006860-a3b8hyyr	5028	8	with	with	IN
cord-006860-a3b8hyyr	5028	9	hemophilia	hemophilia	NN
cord-006860-a3b8hyyr	5028	10	:	:	:
cord-006860-a3b8hyyr	5028	11	detection	detection	NN
cord-006860-a3b8hyyr	5028	12	with	with	IN
cord-006860-a3b8hyyr	5028	13	MR	MR	NNP
cord-006860-a3b8hyyr	5028	14	Imaging	Imaging	NNP
cord-006860-a3b8hyyr	5028	15	MRI	MRI	NNP
cord-006860-a3b8hyyr	5028	16	of	of	IN
cord-006860-a3b8hyyr	5028	17	sickle	sickle	NN
cord-006860-a3b8hyyr	5028	18	cell	cell	NN
cord-006860-a3b8hyyr	5028	19	cerebral	cerebral	JJ
cord-006860-a3b8hyyr	5028	20	infarction	infarction	NN
cord-006860-a3b8hyyr	5029	1	In	in	IN
cord-006860-a3b8hyyr	5029	2	addition	addition	NN
cord-006860-a3b8hyyr	5029	3	,	,	,
cord-006860-a3b8hyyr	5029	4	portions	portion	NNS
cord-006860-a3b8hyyr	5029	5	of	of	IN
cord-006860-a3b8hyyr	5029	6	the	the	DT
cord-006860-a3b8hyyr	5029	7	preparations	preparation	NNS
cord-006860-a3b8hyyr	5029	8	were	be	VBD
cord-006860-a3b8hyyr	5029	9	incubated	incubate	VBN
cord-006860-a3b8hyyr	5029	10	with	with	IN
cord-006860-a3b8hyyr	5029	11	1.4nm	1.4nm	CD
cord-006860-a3b8hyyr	5029	12	-	-	HYPH
cord-006860-a3b8hyyr	5029	13	gold	gold	NN
cord-006860-a3b8hyyr	5029	14	labelled	label	VBN
cord-006860-a3b8hyyr	5029	15	fibrinegen	fibrinegen	NN
cord-006860-a3b8hyyr	5029	16	molecules	molecule	NNS
cord-006860-a3b8hyyr	5029	17	(	(	-LRB-
cord-006860-a3b8hyyr	5029	18	Fg	Fg	NNP
cord-006860-a3b8hyyr	5029	19	-	-	HYPH
cord-006860-a3b8hyyr	5029	20	Au	Au	NNP
cord-006860-a3b8hyyr	5029	21	;	;	,
cord-006860-a3b8hyyr	5029	22	final	final	JJ
cord-006860-a3b8hyyr	5029	23	concentration	concentration	NN
cord-006860-a3b8hyyr	5029	24	4gp_g	4gp_g	CD
cord-006860-a3b8hyyr	5029	25	/	/	SYM
cord-006860-a3b8hyyr	5029	26	ml	ml	NN
cord-006860-a3b8hyyr	5029	27	)	)	-RRB-
cord-006860-a3b8hyyr	5029	28	for	for	IN
cord-006860-a3b8hyyr	5029	29	10	10	CD
cord-006860-a3b8hyyr	5029	30	see	see	NN
cord-006860-a3b8hyyr	5029	31	at	at	IN
cord-006860-a3b8hyyr	5029	32	37	37	CD
cord-006860-a3b8hyyr	5029	33	°	°	NN
cord-006860-a3b8hyyr	5029	34	C	c	NN
cord-006860-a3b8hyyr	5029	35	.	.	.
cord-006860-a3b8hyyr	5030	1	The	the	DT
cord-006860-a3b8hyyr	5030	2	expenments	expenment	NNS
cord-006860-a3b8hyyr	5030	3	were	be	VBD
cord-006860-a3b8hyyr	5030	4	stopped	stop	VBN
cord-006860-a3b8hyyr	5030	5	al	al	NNP
cord-006860-a3b8hyyr	5030	6	~	~	NNP
cord-006860-a3b8hyyr	5030	7	er	er	UH
cord-006860-a3b8hyyr	5030	8	3	3	CD
cord-006860-a3b8hyyr	5030	9	or	or	CC
cord-006860-a3b8hyyr	5030	10	10	10	CD
cord-006860-a3b8hyyr	5030	11	rain	rain	NN
cord-006860-a3b8hyyr	5030	12	by	by	IN
cord-006860-a3b8hyyr	5030	13	glutaraldehyde	glutaraldehyde	JJ
cord-006860-a3b8hyyr	5030	14	fixation	fixation	NN
cord-006860-a3b8hyyr	5030	15	.	.	.
cord-006860-a3b8hyyr	5031	1	Serial	serial	JJ
cord-006860-a3b8hyyr	5031	2	sections	section	NNS
cord-006860-a3b8hyyr	5031	3	were	be	VBD
cord-006860-a3b8hyyr	5031	4	prepared	prepare	VBN
cord-006860-a3b8hyyr	5031	5	and	and	CC
cord-006860-a3b8hyyr	5031	6	examined	examine	VBN
cord-006860-a3b8hyyr	5031	7	after	after	IN
cord-006860-a3b8hyyr	5031	8	silver	silver	NN
cord-006860-a3b8hyyr	5031	9	-	-	HYPH
cord-006860-a3b8hyyr	5031	10	enhancement	enhancement	NN
cord-006860-a3b8hyyr	5031	11	using	use	VBG
cord-006860-a3b8hyyr	5031	12	Danscher	Danscher	NNP
cord-006860-a3b8hyyr	5031	13	's	's	POS
cord-006860-a3b8hyyr	5031	14	(	(	-LRB-
cord-006860-a3b8hyyr	5031	15	1981	1981	CD
cord-006860-a3b8hyyr	5031	16	)	)	-RRB-
cord-006860-a3b8hyyr	5031	17	method	method	NN
cord-006860-a3b8hyyr	5031	18	to	to	TO
cord-006860-a3b8hyyr	5031	19	visualize	visualize	VB
cord-006860-a3b8hyyr	5031	20	the	the	DT
cord-006860-a3b8hyyr	5031	21	Fg	Fg	NNP
cord-006860-a3b8hyyr	5031	22	-	-	HYPH
cord-006860-a3b8hyyr	5031	23	Au	Au	NNP
cord-006860-a3b8hyyr	5031	24	.	.	.
cord-006860-a3b8hyyr	5032	1	HWdid	HWdid	NNP
cord-006860-a3b8hyyr	5032	2	not	not	RB
cord-006860-a3b8hyyr	5032	3	alter	alter	VB
cord-006860-a3b8hyyr	5032	4	the	the	DT
cord-006860-a3b8hyyr	5032	5	resting	rest	VBG
cord-006860-a3b8hyyr	5032	6	GFP	GFP	NNP
cord-006860-a3b8hyyr	5032	7	.	.	.
cord-006860-a3b8hyyr	5033	1	After	after	IN
cord-006860-a3b8hyyr	5033	2	.3,rain	.3,rain	.
cord-006860-a3b8hyyr	5033	3	,	,	,
cord-006860-a3b8hyyr	5033	4	activated	activate	VBN
cord-006860-a3b8hyyr	5033	5	HW	hw	NN
cord-006860-a3b8hyyr	5033	6	-	-	HYPH
cord-006860-a3b8hyyr	5033	7	platelets	platelet	NNS
cord-006860-a3b8hyyr	5033	8	changed	change	VBD
cord-006860-a3b8hyyr	5033	9	their	-PRON-	PRP$
cord-006860-a3b8hyyr	5033	10	shape	shape	NN
cord-006860-a3b8hyyr	5033	11	moderately	moderately	RB
cord-006860-a3b8hyyr	5033	12	but	but	CC
cord-006860-a3b8hyyr	5033	13	in	in	IN
cord-006860-a3b8hyyr	5033	14	contrast	contrast	NN
cord-006860-a3b8hyyr	5033	15	to	to	IN
cord-006860-a3b8hyyr	5033	16	the	the	DT
cord-006860-a3b8hyyr	5033	17	controls	control	NNS
cord-006860-a3b8hyyr	5033	18	did	do	VBD
cord-006860-a3b8hyyr	5033	19	not	not	RB
cord-006860-a3b8hyyr	5033	20	aggregate	aggregate	VB
cord-006860-a3b8hyyr	5033	21	.	.	.
cord-006860-a3b8hyyr	5034	1	Moreover	moreover	RB
cord-006860-a3b8hyyr	5034	2	,	,	,
cord-006860-a3b8hyyr	5034	3	the	the	DT
cord-006860-a3b8hyyr	5034	4	conatdcting	conatdcting	NN
cord-006860-a3b8hyyr	5034	5	cytoskeleton	cytoskeleton	NN
cord-006860-a3b8hyyr	5034	6	that	that	WDT
cord-006860-a3b8hyyr	5034	7	centralizes	centralize	VBZ
cord-006860-a3b8hyyr	5034	8	platelet	platelet	NN
cord-006860-a3b8hyyr	5034	9	organelles	organelle	NNS
cord-006860-a3b8hyyr	5034	10	was	be	VBD
cord-006860-a3b8hyyr	5034	11	not	not	RB
cord-006860-a3b8hyyr	5034	12	formed	form	VBN
cord-006860-a3b8hyyr	5034	13	.	.	.
cord-006860-a3b8hyyr	5035	1	Fg	Fg	NNP
cord-006860-a3b8hyyr	5035	2	-	-	HYPH
cord-006860-a3b8hyyr	5035	3	Au	Au	NNP
cord-006860-a3b8hyyr	5035	4	was	be	VBD
cord-006860-a3b8hyyr	5035	5	found	find	VBN
cord-006860-a3b8hyyr	5035	6	on	on	IN
cord-006860-a3b8hyyr	5035	7	the	the	DT
cord-006860-a3b8hyyr	5035	8	surface	surface	NN
cord-006860-a3b8hyyr	5035	9	of	of	IN
cord-006860-a3b8hyyr	5035	10	the	the	DT
cord-006860-a3b8hyyr	5035	11	control	control	NN
cord-006860-a3b8hyyr	5035	12	platelets	platelet	NNS
cord-006860-a3b8hyyr	5035	13	,	,	,
cord-006860-a3b8hyyr	5035	14	in	in	IN
cord-006860-a3b8hyyr	5035	15	high	high	JJ
cord-006860-a3b8hyyr	5035	16	density	density	NN
cord-006860-a3b8hyyr	5035	17	in	in	IN
cord-006860-a3b8hyyr	5035	18	the	the	DT
cord-006860-a3b8hyyr	5035	19	contact	contact	NN
cord-006860-a3b8hyyr	5035	20	spaces	space	NNS
cord-006860-a3b8hyyr	5035	21	between	between	IN
cord-006860-a3b8hyyr	5035	22	the	the	DT
cord-006860-a3b8hyyr	5035	23	aggregated	aggregated	JJ
cord-006860-a3b8hyyr	5035	24	platelets	platelet	NNS
cord-006860-a3b8hyyr	5035	25	and	and	CC
cord-006860-a3b8hyyr	5035	26	internalized	internalize	VBN
cord-006860-a3b8hyyr	5035	27	in	in	IN
cord-006860-a3b8hyyr	5035	28	the	the	DT
cord-006860-a3b8hyyr	5035	29	surface	surface	NN
cord-006860-a3b8hyyr	5035	30	connected	connect	VBN
cord-006860-a3b8hyyr	5035	31	system	system	NN
cord-006860-a3b8hyyr	5035	32	.	.	.
cord-006860-a3b8hyyr	5036	1	Only	only	RB
cord-006860-a3b8hyyr	5036	2	a	a	DT
cord-006860-a3b8hyyr	5036	3	very	very	RB
cord-006860-a3b8hyyr	5036	4	small	small	JJ
cord-006860-a3b8hyyr	5036	5	number	number	NN
cord-006860-a3b8hyyr	5036	6	of	of	IN
cord-006860-a3b8hyyr	5036	7	HWtreated	hwtreated	JJ
cord-006860-a3b8hyyr	5036	8	cells	cell	NNS
cord-006860-a3b8hyyr	5036	9	had	have	VBD
cord-006860-a3b8hyyr	5036	10	Fg	Fg	NNP
cord-006860-a3b8hyyr	5036	11	-	-	HYPH
cord-006860-a3b8hyyr	5036	12	Au	Au	NNP
cord-006860-a3b8hyyr	5036	13	on	on	IN
cord-006860-a3b8hyyr	5036	14	their	-PRON-	PRP$
cord-006860-a3b8hyyr	5036	15	surface	surface	NN
cord-006860-a3b8hyyr	5036	16	and	and	CC
cord-006860-a3b8hyyr	5036	17	showed	show	VBD
cord-006860-a3b8hyyr	5036	18	internalization	internalization	NN
cord-006860-a3b8hyyr	5036	19	.	.	.
cord-006860-a3b8hyyr	5037	1	10	10	CD
cord-006860-a3b8hyyr	5037	2	rain	rain	NN
cord-006860-a3b8hyyr	5037	3	after	after	IN
cord-006860-a3b8hyyr	5037	4	ADP	ADP	NNP
cord-006860-a3b8hyyr	5037	5	most	most	JJS
cord-006860-a3b8hyyr	5037	6	of	of	IN
cord-006860-a3b8hyyr	5037	7	the	the	DT
cord-006860-a3b8hyyr	5037	8	platelets	platelet	NNS
cord-006860-a3b8hyyr	5037	9	in	in	IN
cord-006860-a3b8hyyr	5037	10	both	both	DT
cord-006860-a3b8hyyr	5037	11	preparations	preparation	NNS
cord-006860-a3b8hyyr	5037	12	had	have	VBD
cord-006860-a3b8hyyr	5037	13	retumod	retumod	NNP
cord-006860-a3b8hyyr	5037	14	to	to	IN
cord-006860-a3b8hyyr	5037	15	a	a	DT
cord-006860-a3b8hyyr	5037	16	discospherecytic	discospherecytic	JJ
cord-006860-a3b8hyyr	5037	17	shape	shape	NN
cord-006860-a3b8hyyr	5037	18	It	-PRON-	PRP
cord-006860-a3b8hyyr	5037	19	is	be	VBZ
cord-006860-a3b8hyyr	5037	20	confirmed	confirm	VBN
cord-006860-a3b8hyyr	5037	21	that	that	IN
cord-006860-a3b8hyyr	5037	22	HW	HW	NNP
cord-006860-a3b8hyyr	5037	23	inhibits	inhibit	VBZ
cord-006860-a3b8hyyr	5037	24	the	the	DT
cord-006860-a3b8hyyr	5037	25	platetet	platetet	JJ
cord-006860-a3b8hyyr	5037	26	aggregation	aggregation	NN
cord-006860-a3b8hyyr	5037	27	and	and	CC
cord-006860-a3b8hyyr	5037	28	in	in	IN
cord-006860-a3b8hyyr	5037	29	addition	addition	NN
cord-006860-a3b8hyyr	5037	30	,	,	,
cord-006860-a3b8hyyr	5037	31	1	1	LS
cord-006860-a3b8hyyr	5037	32	)	)	-RRB-
cord-006860-a3b8hyyr	5037	33	the	the	DT
cord-006860-a3b8hyyr	5037	34	formation	formation	NN
cord-006860-a3b8hyyr	5037	35	of	of	IN
cord-006860-a3b8hyyr	5037	36	the	the	DT
cord-006860-a3b8hyyr	5037	37	contractile	contractile	JJ
cord-006860-a3b8hyyr	5037	38	cytnskeleton	cytnskeleton	NNP
cord-006860-a3b8hyyr	5037	39	as	as	RB
cord-006860-a3b8hyyr	5037	40	well	well	RB
cord-006860-a3b8hyyr	5037	41	as	as	IN
cord-006860-a3b8hyyr	5037	42	2	2	LS
cord-006860-a3b8hyyr	5037	43	)	)	-RRB-
cord-006860-a3b8hyyr	5037	44	the	the	DT
cord-006860-a3b8hyyr	5037	45	binding	binding	NN
cord-006860-a3b8hyyr	5037	46	and	and	CC
cord-006860-a3b8hyyr	5037	47	interalization	interalization	NN
cord-006860-a3b8hyyr	5037	48	of	of	IN
cord-006860-a3b8hyyr	5037	49	the	the	DT
cord-006860-a3b8hyyr	5037	50	used	use	VBN
cord-006860-a3b8hyyr	5037	51	ligand	ligand	NN
cord-006860-a3b8hyyr	5037	52	fibrinogen	fibrinogen	NN
cord-006860-a3b8hyyr	5037	53	Santoso	Santoso	NNP
cord-006860-a3b8hyyr	5037	54	2	2	CD
cord-006860-a3b8hyyr	5037	55	l	l	NNP
cord-006860-a3b8hyyr	5037	56	.	.	.
cord-006860-a3b8hyyr	5037	57	Institute	Institute	NNP
cord-006860-a3b8hyyr	5037	58	for	for	IN
cord-006860-a3b8hyyr	5037	59	Immunology	Immunology	NNP
cord-006860-a3b8hyyr	5037	60	and	and	CC
cord-006860-a3b8hyyr	5037	61	Transfusion	Transfusion	NNP
cord-006860-a3b8hyyr	5037	62	Medicine	Medicine	NNP
cord-006860-a3b8hyyr	5037	63	,	,	,
cord-006860-a3b8hyyr	5037	64	Emst	Emst	NNP
cord-006860-a3b8hyyr	5037	65	-	-	HYPH
cord-006860-a3b8hyyr	5037	66	Moritz	Moritz	NNP
cord-006860-a3b8hyyr	5037	67	-	-	HYPH
cord-006860-a3b8hyyr	5037	68	Arndt	Arndt	NNP
cord-006860-a3b8hyyr	5037	69	-	-	HYPH
cord-006860-a3b8hyyr	5037	70	University	University	NNP
cord-006860-a3b8hyyr	5037	71	Greifswald	Greifswald	NNP
cord-006860-a3b8hyyr	5037	72	;	;	:
cord-006860-a3b8hyyr	5037	73	2	2	CD
cord-006860-a3b8hyyr	5037	74	.	.	.
cord-006860-a3b8hyyr	5038	1	Institute	Institute	NNP
cord-006860-a3b8hyyr	5038	2	for	for	IN
cord-006860-a3b8hyyr	5038	3	Transplant	Transplant	NNP
cord-006860-a3b8hyyr	5038	4	vasculopathy	vasculopathy	NNP
cord-006860-a3b8hyyr	5038	5	in	in	IN
cord-006860-a3b8hyyr	5038	6	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	5038	7	allografts	allografts	NNP
cord-006860-a3b8hyyr	5038	8	is	be	VBZ
cord-006860-a3b8hyyr	5038	9	the	the	DT
cord-006860-a3b8hyyr	5038	10	leading	lead	VBG
cord-006860-a3b8hyyr	5038	11	limitation	limitation	NN
cord-006860-a3b8hyyr	5038	12	to	to	IN
cord-006860-a3b8hyyr	5038	13	long	long	JJ
cord-006860-a3b8hyyr	5038	14	-	-	HYPH
cord-006860-a3b8hyyr	5038	15	term	term	NN
cord-006860-a3b8hyyr	5038	16	survival	survival	NN
cord-006860-a3b8hyyr	5038	17	of	of	IN
cord-006860-a3b8hyyr	5038	18	cardiac	cardiac	JJ
cord-006860-a3b8hyyr	5038	19	transplant	transplant	NN
cord-006860-a3b8hyyr	5038	20	recipients	recipient	NNS
cord-006860-a3b8hyyr	5038	21	.	.	.
cord-006860-a3b8hyyr	5039	1	Activation	activation	NN
cord-006860-a3b8hyyr	5039	2	of	of	IN
cord-006860-a3b8hyyr	5039	3	the	the	DT
cord-006860-a3b8hyyr	5039	4	coagulation	coagulation	NN
cord-006860-a3b8hyyr	5039	5	mechanism	mechanism	NN
cord-006860-a3b8hyyr	5039	6	by	by	IN
cord-006860-a3b8hyyr	5039	7	adherent	adherent	JJ
cord-006860-a3b8hyyr	5039	8	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	5039	9	expressing	express	VBG
cord-006860-a3b8hyyr	5039	10	tissue	tissue	NN
cord-006860-a3b8hyyr	5039	11	factor	factor	NN
cord-006860-a3b8hyyr	5039	12	(	(	-LRB-
cord-006860-a3b8hyyr	5039	13	TF	TF	NNP
cord-006860-a3b8hyyr	5039	14	)	)	-RRB-
cord-006860-a3b8hyyr	5039	15	is	be	VBZ
cord-006860-a3b8hyyr	5039	16	expected	expect	VBN
cord-006860-a3b8hyyr	5039	17	to	to	TO
cord-006860-a3b8hyyr	5039	18	be	be	VB
cord-006860-a3b8hyyr	5039	19	involved	involve	VBN
cord-006860-a3b8hyyr	5039	20	in	in	IN
cord-006860-a3b8hyyr	5039	21	the	the	DT
cord-006860-a3b8hyyr	5039	22	development	development	NN
cord-006860-a3b8hyyr	5039	23	of	of	IN
cord-006860-a3b8hyyr	5039	24	transplant	transplant	NN
cord-006860-a3b8hyyr	5039	25	atherosclerosis	atherosclerosis	NN
cord-006860-a3b8hyyr	5039	26	.	.	.
cord-006860-a3b8hyyr	5040	1	In	in	IN
cord-006860-a3b8hyyr	5040	2	this	this	DT
cord-006860-a3b8hyyr	5040	3	in	in	FW
cord-006860-a3b8hyyr	5040	4	vitro	vitro	FW
cord-006860-a3b8hyyr	5040	5	study	study	VB
cord-006860-a3b8hyyr	5040	6	the	the	DT
cord-006860-a3b8hyyr	5040	7	effect	effect	NN
cord-006860-a3b8hyyr	5040	8	of	of	IN
cord-006860-a3b8hyyr	5040	9	the	the	DT
cord-006860-a3b8hyyr	5040	10	immunosuppressant	immunosuppressant	JJ
cord-006860-a3b8hyyr	5040	11	Cyclosporine	Cyclosporine	NNP
cord-006860-a3b8hyyr	5040	12	A	A	NNP
cord-006860-a3b8hyyr	5040	13	(	(	-LRB-
cord-006860-a3b8hyyr	5040	14	CsA	CsA	NNP
cord-006860-a3b8hyyr	5040	15	)	)	-RRB-
cord-006860-a3b8hyyr	5040	16	on	on	IN
cord-006860-a3b8hyyr	5040	17	monocyte	monocyte	NNP
cord-006860-a3b8hyyr	5040	18	TF	TF	NNP
cord-006860-a3b8hyyr	5040	19	expression	expression	NN
cord-006860-a3b8hyyr	5040	20	and	and	CC
cord-006860-a3b8hyyr	5040	21	the	the	DT
cord-006860-a3b8hyyr	5040	22	regulation	regulation	NN
cord-006860-a3b8hyyr	5040	23	of	of	IN
cord-006860-a3b8hyyr	5040	24	the	the	DT
cord-006860-a3b8hyyr	5040	25	TF	TF	NNP
cord-006860-a3b8hyyr	5040	26	gene	gene	NN
cord-006860-a3b8hyyr	5040	27	transcription	transcription	NN
cord-006860-a3b8hyyr	5040	28	was	be	VBD
cord-006860-a3b8hyyr	5040	29	analysed	analyse	VBN
cord-006860-a3b8hyyr	5040	30	.	.	.
cord-006860-a3b8hyyr	5041	1	CsA	CsA	NNP
cord-006860-a3b8hyyr	5041	2	was	be	VBD
cord-006860-a3b8hyyr	5041	3	shown	show	VBN
cord-006860-a3b8hyyr	5041	4	to	to	TO
cord-006860-a3b8hyyr	5041	5	inhibit	inhibit	VB
cord-006860-a3b8hyyr	5041	6	the	the	DT
cord-006860-a3b8hyyr	5041	7	induction	induction	NN
cord-006860-a3b8hyyr	5041	8	of	of	IN
cord-006860-a3b8hyyr	5041	9	monocyte	monocyte	NNP
cord-006860-a3b8hyyr	5041	10	procoagulant	procoagulant	NNP
cord-006860-a3b8hyyr	5041	11	activity	activity	NNP
cord-006860-a3b8hyyr	5041	12	(	(	-LRB-
cord-006860-a3b8hyyr	5041	13	PCA	PCA	NNP
cord-006860-a3b8hyyr	5041	14	)	)	-RRB-
cord-006860-a3b8hyyr	5041	15	by	by	IN
cord-006860-a3b8hyyr	5041	16	decreasing	decrease	VBG
cord-006860-a3b8hyyr	5041	17	lipopolysaccharide	lipopolysaccharide	NN
cord-006860-a3b8hyyr	5041	18	(	(	-LRB-
cord-006860-a3b8hyyr	5041	19	LPS)-induced	lps)-induced	JJ
cord-006860-a3b8hyyr	5041	20	tissue	tissue	NN
cord-006860-a3b8hyyr	5041	21	factor	factor	NN
cord-006860-a3b8hyyr	5041	22	(	(	-LRB-
cord-006860-a3b8hyyr	5041	23	TF	TF	NNP
cord-006860-a3b8hyyr	5041	24	)	)	-RRB-
cord-006860-a3b8hyyr	5041	25	expression	expression	NN
cord-006860-a3b8hyyr	5041	26	in	in	IN
cord-006860-a3b8hyyr	5041	27	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	5041	28	.	.	.
cord-006860-a3b8hyyr	5042	1	CsA	CsA	NNP
cord-006860-a3b8hyyr	5042	2	exerted	exert	VBD
cord-006860-a3b8hyyr	5042	3	a	a	DT
cord-006860-a3b8hyyr	5042	4	dosedependent	dosedependent	NN
cord-006860-a3b8hyyr	5042	5	inhibitory	inhibitory	JJ
cord-006860-a3b8hyyr	5042	6	effect	effect	NN
cord-006860-a3b8hyyr	5042	7	on	on	IN
cord-006860-a3b8hyyr	5042	8	monocyte	monocyte	NNP
cord-006860-a3b8hyyr	5042	9	TF	TF	NNP
cord-006860-a3b8hyyr	5042	10	expression	expression	NN
cord-006860-a3b8hyyr	5042	11	at	at	IN
cord-006860-a3b8hyyr	5042	12	concentrations	concentration	NNS
cord-006860-a3b8hyyr	5042	13	(	(	-LRB-
cord-006860-a3b8hyyr	5042	14	1,5	1,5	CD
cord-006860-a3b8hyyr	5042	15	txmol	txmol	NNP
cord-006860-a3b8hyyr	5042	16	/	/	SYM
cord-006860-a3b8hyyr	5042	17	L	L	NNP
cord-006860-a3b8hyyr	5042	18	CsA	CsA	NNP
cord-006860-a3b8hyyr	5042	19	:	:	:
cord-006860-a3b8hyyr	5042	20	50	50	CD
cord-006860-a3b8hyyr	5042	21	%	%	NN
cord-006860-a3b8hyyr	5042	22	inhibition	inhibition	NN
cord-006860-a3b8hyyr	5042	23	)	)	-RRB-
cord-006860-a3b8hyyr	5042	24	not	not	RB
cord-006860-a3b8hyyr	5042	25	decreasing	decrease	VBG
cord-006860-a3b8hyyr	5042	26	the	the	DT
cord-006860-a3b8hyyr	5042	27	cellular	cellular	JJ
cord-006860-a3b8hyyr	5042	28	protein	protein	NN
cord-006860-a3b8hyyr	5042	29	synthetic	synthetic	JJ
cord-006860-a3b8hyyr	5042	30	rate	rate	NN
cord-006860-a3b8hyyr	5042	31	.	.	.
cord-006860-a3b8hyyr	5043	1	Addition	addition	NN
cord-006860-a3b8hyyr	5043	2	of	of	IN
cord-006860-a3b8hyyr	5043	3	CsA	csa	NN
cord-006860-a3b8hyyr	5043	4	during	during	IN
cord-006860-a3b8hyyr	5043	5	LPSstimulation	lpsstimulation	NN
cord-006860-a3b8hyyr	5043	6	prevented	prevent	VBD
cord-006860-a3b8hyyr	5043	7	activation	activation	NN
cord-006860-a3b8hyyr	5043	8	of	of	IN
cord-006860-a3b8hyyr	5043	9	the	the	DT
cord-006860-a3b8hyyr	5043	10	nuclear	nuclear	JJ
cord-006860-a3b8hyyr	5043	11	factor	factor	NN
cord-006860-a3b8hyyr	5043	12	(	(	-LRB-
cord-006860-a3b8hyyr	5043	13	NF	nf	NN
cord-006860-a3b8hyyr	5043	14	)	)	-RRB-
cord-006860-a3b8hyyr	5043	15	~B	~B	NFP
cord-006860-a3b8hyyr	5043	16	as	as	IN
cord-006860-a3b8hyyr	5043	17	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	5043	18	by	by	IN
cord-006860-a3b8hyyr	5043	19	electrophoretic	electrophoretic	JJ
cord-006860-a3b8hyyr	5043	20	mobility	mobility	NN
cord-006860-a3b8hyyr	5043	21	shift	shift	NN
cord-006860-a3b8hyyr	5043	22	assay	assay	NN
cord-006860-a3b8hyyr	5043	23	.	.	.
cord-006860-a3b8hyyr	5044	1	Western	western	JJ
cord-006860-a3b8hyyr	5044	2	blot	blot	NN
cord-006860-a3b8hyyr	5044	3	analysis	analysis	NN
cord-006860-a3b8hyyr	5044	4	confirmed	confirm	VBD
cord-006860-a3b8hyyr	5044	5	reduced	reduce	VBN
cord-006860-a3b8hyyr	5044	6	nuclear	nuclear	JJ
cord-006860-a3b8hyyr	5044	7	translocation	translocation	NN
cord-006860-a3b8hyyr	5044	8	of	of	IN
cord-006860-a3b8hyyr	5044	9	NF-~B	NF-~B	NNP
cord-006860-a3b8hyyr	5044	10	in	in	IN
cord-006860-a3b8hyyr	5044	11	the	the	DT
cord-006860-a3b8hyyr	5044	12	presence	presence	NN
cord-006860-a3b8hyyr	5044	13	of	of	IN
cord-006860-a3b8hyyr	5044	14	CsA.	CsA.	NNP
cord-006860-a3b8hyyr	5044	15	Inhibition	Inhibition	NNP
cord-006860-a3b8hyyr	5044	16	of	of	IN
cord-006860-a3b8hyyr	5044	17	the	the	DT
cord-006860-a3b8hyyr	5044	18	LPS	LPS	NNP
cord-006860-a3b8hyyr	5044	19	-	-	HYPH
cord-006860-a3b8hyyr	5044	20	induced	induce	VBN
cord-006860-a3b8hyyr	5044	21	NF-~B	NF-~B	NNP
cord-006860-a3b8hyyr	5044	22	activation	activation	NN
cord-006860-a3b8hyyr	5044	23	by	by	IN
cord-006860-a3b8hyyr	5044	24	CsA	CsA	NNP
cord-006860-a3b8hyyr	5044	25	resulted	result	VBD
cord-006860-a3b8hyyr	5044	26	in	in	IN
cord-006860-a3b8hyyr	5044	27	a	a	DT
cord-006860-a3b8hyyr	5044	28	reduced	reduce	VBN
cord-006860-a3b8hyyr	5044	29	TF	TF	NNP
cord-006860-a3b8hyyr	5044	30	gene	gene	NN
cord-006860-a3b8hyyr	5044	31	transcription	transcription	NN
cord-006860-a3b8hyyr	5044	32	as	as	IN
cord-006860-a3b8hyyr	5044	33	demonstrated	demonstrate	VBN
cord-006860-a3b8hyyr	5044	34	by	by	IN
cord-006860-a3b8hyyr	5044	35	RT	RT	NNP
cord-006860-a3b8hyyr	5044	36	-	-	HYPH
cord-006860-a3b8hyyr	5044	37	PCR	pcr	NN
cord-006860-a3b8hyyr	5044	38	-	-	HYPH
cord-006860-a3b8hyyr	5044	39	analysis	analysis	NN
cord-006860-a3b8hyyr	5044	40	.	.	.
cord-006860-a3b8hyyr	5045	1	Thus	thus	RB
cord-006860-a3b8hyyr	5045	2	,	,	,
cord-006860-a3b8hyyr	5045	3	Cyclosporine	Cyclosporine	NNP
cord-006860-a3b8hyyr	5045	4	A	A	NNP
cord-006860-a3b8hyyr	5045	5	prevents	prevent	VBZ
cord-006860-a3b8hyyr	5045	6	TF	TF	NNP
cord-006860-a3b8hyyr	5045	7	expression	expression	NN
cord-006860-a3b8hyyr	5045	8	by	by	IN
cord-006860-a3b8hyyr	5045	9	inhibiting	inhibit	VBG
cord-006860-a3b8hyyr	5045	10	the	the	DT
cord-006860-a3b8hyyr	5045	11	induction	induction	NN
cord-006860-a3b8hyyr	5045	12	of	of	IN
cord-006860-a3b8hyyr	5045	13	TF	TF	NNP
cord-006860-a3b8hyyr	5045	14	gene	gene	NN
cord-006860-a3b8hyyr	5045	15	transcription	transcription	NN
cord-006860-a3b8hyyr	5045	16	in	in	IN
cord-006860-a3b8hyyr	5045	17	activated	activate	VBN
cord-006860-a3b8hyyr	5045	18	monocytes	monocyte	NNS
cord-006860-a3b8hyyr	5045	19	.	.	.
cord-006860-a3b8hyyr	5046	1	CsA	CsA	NNP
cord-006860-a3b8hyyr	5046	2	may	may	MD
cord-006860-a3b8hyyr	5046	3	therefore	therefore	RB
cord-006860-a3b8hyyr	5046	4	provide	provide	VB
cord-006860-a3b8hyyr	5046	5	a	a	DT
cord-006860-a3b8hyyr	5046	6	therapeutical	therapeutical	JJ
cord-006860-a3b8hyyr	5046	7	tool	tool	NN
cord-006860-a3b8hyyr	5046	8	acting	act	VBG
cord-006860-a3b8hyyr	5046	9	not	not	RB
cord-006860-a3b8hyyr	5046	10	only	only	RB
cord-006860-a3b8hyyr	5046	11	as	as	IN
cord-006860-a3b8hyyr	5046	12	a	a	DT
cord-006860-a3b8hyyr	5046	13	direct	direct	JJ
cord-006860-a3b8hyyr	5046	14	immunomodulating	immunomodulating	JJ
cord-006860-a3b8hyyr	5046	15	agent	agent	NN
cord-006860-a3b8hyyr	5046	16	,	,	,
cord-006860-a3b8hyyr	5046	17	but	but	CC
cord-006860-a3b8hyyr	5046	18	also	also	RB
cord-006860-a3b8hyyr	5046	19	by	by	IN
cord-006860-a3b8hyyr	5046	20	influencing	influence	VBG
cord-006860-a3b8hyyr	5046	21	local	local	JJ
cord-006860-a3b8hyyr	5046	22	coagulation	coagulation	NN
cord-006860-a3b8hyyr	5046	23	activation	activation	NN
cord-006860-a3b8hyyr	5046	24	.	.	.
cord-006860-a3b8hyyr	5047	1	The	the	DT
cord-006860-a3b8hyyr	5047	2	N	N	NNP
cord-006860-a3b8hyyr	5047	3	-	-	HYPH
cord-006860-a3b8hyyr	5047	4	glyean	glyean	JJ
cord-006860-a3b8hyyr	5047	5	pattern	pattern	NN
cord-006860-a3b8hyyr	5047	6	of	of	IN
cord-006860-a3b8hyyr	5047	7	recombinant	recombinant	JJ
cord-006860-a3b8hyyr	5047	8	human	human	JJ
cord-006860-a3b8hyyr	5047	9	coagulation	coagulation	NN
cord-006860-a3b8hyyr	5047	10	factors	factor	NNS
cord-006860-a3b8hyyr	5047	11	II	II	NNP
cord-006860-a3b8hyyr	5047	12	(	(	-LRB-
cord-006860-a3b8hyyr	5047	13	rF	rF	NNP
cord-006860-a3b8hyyr	5047	14	-	-	HYPH
cord-006860-a3b8hyyr	5047	15	I~	I~	NNP
cord-006860-a3b8hyyr	5047	16	and	and	CC
cord-006860-a3b8hyyr	5047	17	IX	IX	NNP
cord-006860-a3b8hyyr	5047	18	(	(	-LRB-
cord-006860-a3b8hyyr	5047	19	rF	rF	NNP
cord-006860-a3b8hyyr	5047	20	-	-	HYPH
cord-006860-a3b8hyyr	5047	21	IX	IX	NNP
cord-006860-a3b8hyyr	5047	22	)	)	-RRB-
cord-006860-a3b8hyyr	5047	23	,	,	,
cord-006860-a3b8hyyr	5047	24	derived	derive	VBN
cord-006860-a3b8hyyr	5047	25	from	from	IN
cord-006860-a3b8hyyr	5047	26	both	both	DT
cord-006860-a3b8hyyr	5047	27	transfected	transfecte	VBN
cord-006860-a3b8hyyr	5047	28	Chinese	chinese	JJ
cord-006860-a3b8hyyr	5047	29	hamster	hamster	NN
cord-006860-a3b8hyyr	5047	30	ovary	ovary	NN
cord-006860-a3b8hyyr	5047	31	(	(	-LRB-
cord-006860-a3b8hyyr	5047	32	CHO	CHO	NNP
cord-006860-a3b8hyyr	5047	33	)	)	-RRB-
cord-006860-a3b8hyyr	5047	34	cells	cell	NNS
cord-006860-a3b8hyyr	5047	35	and	and	CC
cord-006860-a3b8hyyr	5047	36	African	african	JJ
cord-006860-a3b8hyyr	5047	37	green	green	JJ
cord-006860-a3b8hyyr	5047	38	monkey	monkey	NN
cord-006860-a3b8hyyr	5047	39	(	(	-LRB-
cord-006860-a3b8hyyr	5047	40	Vero	Vero	NNP
cord-006860-a3b8hyyr	5047	41	)	)	-RRB-
cord-006860-a3b8hyyr	5047	42	cells	cell	NNS
cord-006860-a3b8hyyr	5047	43	,	,	,
cord-006860-a3b8hyyr	5047	44	and	and	CC
cord-006860-a3b8hyyr	5047	45	produced	produce	VBN
cord-006860-a3b8hyyr	5047	46	at	at	IN
cord-006860-a3b8hyyr	5047	47	industrial	industrial	JJ
cord-006860-a3b8hyyr	5047	48	scale	scale	NN
cord-006860-a3b8hyyr	5047	49	were	be	VBD
cord-006860-a3b8hyyr	5047	50	analyzed	analyze	VBN
cord-006860-a3b8hyyr	5047	51	by	by	IN
cord-006860-a3b8hyyr	5047	52	binding	bind	VBG
cord-006860-a3b8hyyr	5047	53	to	to	IN
cord-006860-a3b8hyyr	5047	54	carbohydrate	carbohydrate	NN
cord-006860-a3b8hyyr	5047	55	specific	specific	JJ
cord-006860-a3b8hyyr	5047	56	lectins	lectin	NNS
cord-006860-a3b8hyyr	5047	57	and	and	CC
cord-006860-a3b8hyyr	5047	58	were	be	VBD
cord-006860-a3b8hyyr	5047	59	compared	compare	VBN
cord-006860-a3b8hyyr	5047	60	with	with	IN
cord-006860-a3b8hyyr	5047	61	the	the	DT
cord-006860-a3b8hyyr	5047	62	glycan	glycan	NN
cord-006860-a3b8hyyr	5047	63	structure	structure	NN
cord-006860-a3b8hyyr	5047	64	of	of	IN
cord-006860-a3b8hyyr	5047	65	human	human	JJ
cord-006860-a3b8hyyr	5047	66	plasma	plasma	NN
cord-006860-a3b8hyyr	5047	67	-	-	HYPH
cord-006860-a3b8hyyr	5047	68	derived	derive	VBN
cord-006860-a3b8hyyr	5047	69	coagulation	coagulation	NN
cord-006860-a3b8hyyr	5047	70	factors	factor	NNS
cord-006860-a3b8hyyr	5047	71	.	.	.
cord-006860-a3b8hyyr	5048	1	Human	human	JJ
cord-006860-a3b8hyyr	5048	2	plasma	plasma	NN
cord-006860-a3b8hyyr	5048	3	-	-	HYPH
cord-006860-a3b8hyyr	5048	4	derived	derive	VBN
cord-006860-a3b8hyyr	5048	5	coagulation	coagulation	NN
cord-006860-a3b8hyyr	5048	6	factors	factor	NNS
cord-006860-a3b8hyyr	5048	7	1I	1i	CD
cord-006860-a3b8hyyr	5048	8	(	(	-LRB-
cord-006860-a3b8hyyr	5048	9	hpF	hpF	NNP
cord-006860-a3b8hyyr	5048	10	-	-	HYPH
cord-006860-a3b8hyyr	5048	11	I1	i1	NN
cord-006860-a3b8hyyr	5048	12	)	)	-RRB-
cord-006860-a3b8hyyr	5048	13	and	and	CC
cord-006860-a3b8hyyr	5048	14	IX	IX	NNP
cord-006860-a3b8hyyr	5048	15	(	(	-LRB-
cord-006860-a3b8hyyr	5048	16	hpF	hpF	NNP
cord-006860-a3b8hyyr	5048	17	-	-	HYPH
cord-006860-a3b8hyyr	5048	18	ix	ix	NN
cord-006860-a3b8hyyr	5048	19	)	)	-RRB-
cord-006860-a3b8hyyr	5048	20	exhibited	exhibit	VBD
cord-006860-a3b8hyyr	5048	21	complex	complex	JJ
cord-006860-a3b8hyyr	5048	22	-	-	HYPH
cord-006860-a3b8hyyr	5048	23	type	type	NN
cord-006860-a3b8hyyr	5048	24	glycan	glycan	NN
cord-006860-a3b8hyyr	5048	25	structures	structure	NNS
cord-006860-a3b8hyyr	5048	26	with	with	IN
cord-006860-a3b8hyyr	5048	27	carbohydrate	carbohydrate	NN
cord-006860-a3b8hyyr	5048	28	chains	chain	NNS
cord-006860-a3b8hyyr	5048	29	capped	cap	VBN
cord-006860-a3b8hyyr	5048	30	with	with	IN
cord-006860-a3b8hyyr	5048	31	c~(2	c~(2	NNP
cord-006860-a3b8hyyr	5048	32	-	-	HYPH
cord-006860-a3b8hyyr	5048	33	6)sialic	6)sialic	JJ
cord-006860-a3b8hyyr	5048	34	acid	acid	NN
cord-006860-a3b8hyyr	5048	35	.	.	.
cord-006860-a3b8hyyr	5049	1	Terminal	terminal	JJ
cord-006860-a3b8hyyr	5049	2	galactose	galactose	NN
cord-006860-a3b8hyyr	5049	3	-	-	HYPH
cord-006860-a3b8hyyr	5049	4	B(1	B(1	NNP
cord-006860-a3b8hyyr	5049	5	-	-	HYPH
cord-006860-a3b8hyyr	5049	6	4)-N	4)-n	CD
cord-006860-a3b8hyyr	5049	7	-	-	HYPH
cord-006860-a3b8hyyr	5049	8	acetylglucosamine	acetylglucosamine	NN
cord-006860-a3b8hyyr	5049	9	units	unit	NNS
cord-006860-a3b8hyyr	5049	10	were	be	VBD
cord-006860-a3b8hyyr	5049	11	detected	detect	VBN
cord-006860-a3b8hyyr	5049	12	in	in	IN
cord-006860-a3b8hyyr	5049	13	hpF	hpf	JJ
cord-006860-a3b8hyyr	5049	14	-	-	HYPH
cord-006860-a3b8hyyr	5049	15	IX	IX	NNP
cord-006860-a3b8hyyr	5049	16	.	.	.
cord-006860-a3b8hyyr	5050	1	Both	both	DT
cord-006860-a3b8hyyr	5050	2	CHO	CHO	NNP
cord-006860-a3b8hyyr	5050	3	cell	cell	NN
cord-006860-a3b8hyyr	5050	4	-	-	HYPH
cord-006860-a3b8hyyr	5050	5	derived	derive	VBN
cord-006860-a3b8hyyr	5050	6	rF-]I	rf-]i	NN
cord-006860-a3b8hyyr	5050	7	and	and	CC
cord-006860-a3b8hyyr	5050	8	rF	rF	NNP
cord-006860-a3b8hyyr	5050	9	-	-	HYPH
cord-006860-a3b8hyyr	5050	10	IX	IX	NNP
cord-006860-a3b8hyyr	5050	11	exhibited	exhibit	VBD
cord-006860-a3b8hyyr	5050	12	complot	complot	NN
cord-006860-a3b8hyyr	5050	13	-	-	HYPH
cord-006860-a3b8hyyr	5050	14	type	type	NN
cord-006860-a3b8hyyr	5050	15	glycosylafion	glycosylafion	NN
cord-006860-a3b8hyyr	5050	16	and	and	CC
cord-006860-a3b8hyyr	5050	17	contained	contain	VBD
cord-006860-a3b8hyyr	5050	18	~2	~2	NNP
cord-006860-a3b8hyyr	5050	19	-	-	HYPH
cord-006860-a3b8hyyr	5050	20	3)-sialio	3)-sialio	CD
cord-006860-a3b8hyyr	5050	21	acid	acid	NN
cord-006860-a3b8hyyr	5050	22	in	in	IN
cord-006860-a3b8hyyr	5050	23	addition	addition	NN
cord-006860-a3b8hyyr	5050	24	to	to	IN
cord-006860-a3b8hyyr	5050	25	terminal	terminal	JJ
cord-006860-a3b8hyyr	5050	26	galactose	galactose	NN
cord-006860-a3b8hyyr	5050	27	-	-	HYPH
cord-006860-a3b8hyyr	5050	28	B(1	B(1	NNP
cord-006860-a3b8hyyr	5050	29	-	-	HYPH
cord-006860-a3b8hyyr	5050	30	4)-N	4)-n	CD
cord-006860-a3b8hyyr	5050	31	-	-	HYPH
cord-006860-a3b8hyyr	5050	32	acetylglucosamine	acetylglucosamine	NN
cord-006860-a3b8hyyr	5050	33	.	.	.
cord-006860-a3b8hyyr	5051	1	Vero	Vero	NNP
cord-006860-a3b8hyyr	5051	2	cell	cell	NN
cord-006860-a3b8hyyr	5051	3	-	-	HYPH
cord-006860-a3b8hyyr	5051	4	derived	derive	VBN
cord-006860-a3b8hyyr	5051	5	if	if	IN
cord-006860-a3b8hyyr	5051	6	-	-	HYPH
cord-006860-a3b8hyyr	5051	7	IX	IX	NNP
cord-006860-a3b8hyyr	5051	8	exhibited	exhibit	VBD
cord-006860-a3b8hyyr	5051	9	a	a	DT
cord-006860-a3b8hyyr	5051	10	complex	complex	JJ
cord-006860-a3b8hyyr	5051	11	-	-	HYPH
cord-006860-a3b8hyyr	5051	12	type	type	NN
cord-006860-a3b8hyyr	5051	13	glycan	glycan	NN
cord-006860-a3b8hyyr	5051	14	structure	structure	NN
cord-006860-a3b8hyyr	5051	15	sinailar	sinailar	NNP
cord-006860-a3b8hyyr	5051	16	to	to	IN
cord-006860-a3b8hyyr	5051	17	that	that	DT
cord-006860-a3b8hyyr	5051	18	of	of	IN
cord-006860-a3b8hyyr	5051	19	CHO	CHO	NNP
cord-006860-a3b8hyyr	5051	20	cell	cell	NN
cord-006860-a3b8hyyr	5051	21	derived	derive	VBN
cord-006860-a3b8hyyr	5051	22	rF	rF	NNP
cord-006860-a3b8hyyr	5051	23	-	-	HYPH
cord-006860-a3b8hyyr	5051	24	IX	IX	NNP
cord-006860-a3b8hyyr	5051	25	.	.	.
cord-006860-a3b8hyyr	5052	1	In	in	IN
cord-006860-a3b8hyyr	5052	2	contrast	contrast	NN
cord-006860-a3b8hyyr	5052	3	,	,	,
cord-006860-a3b8hyyr	5052	4	rF	rF	NNP
cord-006860-a3b8hyyr	5052	5	-	-	HYPH
cord-006860-a3b8hyyr	5052	6	lI	lI	NNP
cord-006860-a3b8hyyr	5052	7	produced	produce	VBN
cord-006860-a3b8hyyr	5052	8	by	by	IN
cord-006860-a3b8hyyr	5052	9	Vero	Vero	NNP
cord-006860-a3b8hyyr	5052	10	cells	cell	NNS
cord-006860-a3b8hyyr	5052	11	exhibited	exhibit	VBD
cord-006860-a3b8hyyr	5052	12	a	a	DT
cord-006860-a3b8hyyr	5052	13	glycan	glycan	NN
cord-006860-a3b8hyyr	5052	14	microheterogeneity	microheterogeneity	NN
cord-006860-a3b8hyyr	5052	15	composed	compose	VBN
cord-006860-a3b8hyyr	5052	16	of	of	IN
cord-006860-a3b8hyyr	5052	17	hybrid	hybrid	JJ
cord-006860-a3b8hyyr	5052	18	-	-	HYPH
cord-006860-a3b8hyyr	5052	19	type	type	NN
cord-006860-a3b8hyyr	5052	20	glycosylation	glycosylation	NN
cord-006860-a3b8hyyr	5052	21	containing	contain	VBG
cord-006860-a3b8hyyr	5052	22	"	"	``
cord-006860-a3b8hyyr	5052	23	highmarmose	highmarmose	JJ
cord-006860-a3b8hyyr	5052	24	"	"	''
cord-006860-a3b8hyyr	5052	25	structures	structure	NNS
cord-006860-a3b8hyyr	5052	26	and	and	CC
cord-006860-a3b8hyyr	5052	27	complex	complex	JJ
cord-006860-a3b8hyyr	5052	28	-	-	HYPH
cord-006860-a3b8hyyr	5052	29	type	type	NN
cord-006860-a3b8hyyr	5052	30	glycosylation	glycosylation	NN
cord-006860-a3b8hyyr	5052	31	containing	contain	VBG
cord-006860-a3b8hyyr	5052	32	et(2	et(2	NNP
cord-006860-a3b8hyyr	5052	33	-	-	HYPH
cord-006860-a3b8hyyr	5052	34	3)-sialie	3)-sialie	CD
cord-006860-a3b8hyyr	5052	35	acid	acid	NN
cord-006860-a3b8hyyr	5052	36	.	.	.
cord-006860-a3b8hyyr	5053	1	Galaetose	Galaetose	NNP
cord-006860-a3b8hyyr	5053	2	-	-	HYPH
cord-006860-a3b8hyyr	5053	3	B(1	B(1	NNP
cord-006860-a3b8hyyr	5053	4	-	-	HYPH
cord-006860-a3b8hyyr	5053	5	4)-N	4)-n	CD
cord-006860-a3b8hyyr	5053	6	-	-	HYPH
cord-006860-a3b8hyyr	5053	7	acetylglucosamine	acetylglucosamine	NN
cord-006860-a3b8hyyr	5053	8	structures	structure	NNS
cord-006860-a3b8hyyr	5053	9	and	and	CC
cord-006860-a3b8hyyr	5053	10	a	a	DT
cord-006860-a3b8hyyr	5053	11	low	low	JJ
cord-006860-a3b8hyyr	5053	12	concentration	concentration	NN
cord-006860-a3b8hyyr	5053	13	of	of	IN
cord-006860-a3b8hyyr	5053	14	ct(2	ct(2	NNP
cord-006860-a3b8hyyr	5053	15	-	-	HYPH
cord-006860-a3b8hyyr	5053	16	6)-sialic	6)-sialic	CD
cord-006860-a3b8hyyr	5053	17	acid	acid	NN
cord-006860-a3b8hyyr	5053	18	were	be	VBD
cord-006860-a3b8hyyr	5053	19	detected	detect	VBN
cord-006860-a3b8hyyr	5053	20	in	in	IN
cord-006860-a3b8hyyr	5053	21	both	both	DT
cord-006860-a3b8hyyr	5053	22	micro	micro	JJ
cord-006860-a3b8hyyr	5053	23	-	-	JJ
cord-006860-a3b8hyyr	5053	24	heterogeneity	heterogeneity	NN
cord-006860-a3b8hyyr	5053	25	fractions	fraction	NNS
cord-006860-a3b8hyyr	5053	26	of	of	IN
cord-006860-a3b8hyyr	5053	27	Veto	veto	NN
cord-006860-a3b8hyyr	5053	28	cell	cell	NN
cord-006860-a3b8hyyr	5053	29	-	-	HYPH
cord-006860-a3b8hyyr	5053	30	derived	derive	VBN
cord-006860-a3b8hyyr	5053	31	rF	rf	NN
cord-006860-a3b8hyyr	5053	32	-	-	NN
cord-006860-a3b8hyyr	5053	33	lI.	li.	JJ
cord-006860-a3b8hyyr	5054	1	Although	although	IN
cord-006860-a3b8hyyr	5054	2	different	different	JJ
cord-006860-a3b8hyyr	5054	3	in	in	IN
cord-006860-a3b8hyyr	5054	4	the'tr	the'tr	CD
cord-006860-a3b8hyyr	5054	5	carbohydrate	carbohydrate	NN
cord-006860-a3b8hyyr	5054	6	structures	structure	NNS
cord-006860-a3b8hyyr	5054	7	,	,	,
cord-006860-a3b8hyyr	5054	8	coagulation	coagulation	NN
cord-006860-a3b8hyyr	5054	9	factors	factor	NNS
cord-006860-a3b8hyyr	5054	10	II	II	NNP
cord-006860-a3b8hyyr	5054	11	and	and	CC
cord-006860-a3b8hyyr	5054	12	IX	IX	NNP
cord-006860-a3b8hyyr	5054	13	obtained	obtain	VBD
cord-006860-a3b8hyyr	5054	14	recombinantly	recombinantly	RB
cord-006860-a3b8hyyr	5054	15	from	from	IN
cord-006860-a3b8hyyr	5054	16	both	both	CC
cord-006860-a3b8hyyr	5054	17	transformed	transform	VBN
cord-006860-a3b8hyyr	5054	18	CHO	CHO	NNP
cord-006860-a3b8hyyr	5054	19	-	-	HYPH
cord-006860-a3b8hyyr	5054	20	cells	cell	NNS
cord-006860-a3b8hyyr	5054	21	and	and	CC
cord-006860-a3b8hyyr	5055	1	Vero	Vero	NNP
cord-006860-a3b8hyyr	5055	2	-	-	HYPH
cord-006860-a3b8hyyr	5055	3	cells	cell	NNS
cord-006860-a3b8hyyr	5055	4	exhibited	exhibit	VBD
cord-006860-a3b8hyyr	5055	5	coagulation	coagulation	NN
cord-006860-a3b8hyyr	5055	6	activities	activity	NNS
cord-006860-a3b8hyyr	5055	7	comparable	comparable	JJ
cord-006860-a3b8hyyr	5055	8	to	to	IN
cord-006860-a3b8hyyr	5055	9	the	the	DT
cord-006860-a3b8hyyr	5055	10	plasma	plasma	NN
cord-006860-a3b8hyyr	5055	11	-	-	HYPH
cord-006860-a3b8hyyr	5055	12	derived	derive	VBN
cord-006860-a3b8hyyr	5055	13	proteins	protein	NNS
cord-006860-a3b8hyyr	5055	14	.	.	.
cord-006860-a3b8hyyr	5056	1	Exposure	exposure	NN
cord-006860-a3b8hyyr	5056	2	of	of	IN
cord-006860-a3b8hyyr	5056	3	tissue	tissue	NN
cord-006860-a3b8hyyr	5056	4	factor	factor	NN
cord-006860-a3b8hyyr	5056	5	(	(	-LRB-
cord-006860-a3b8hyyr	5056	6	TF	TF	NNP
cord-006860-a3b8hyyr	5056	7	)	)	-RRB-
cord-006860-a3b8hyyr	5056	8	to	to	IN
cord-006860-a3b8hyyr	5056	9	flowing	flow	VBG
cord-006860-a3b8hyyr	5056	10	blood	blood	NN
cord-006860-a3b8hyyr	5056	11	,	,	,
cord-006860-a3b8hyyr	5056	12	as	as	IN
cord-006860-a3b8hyyr	5056	13	a	a	DT
cord-006860-a3b8hyyr	5056	14	consequence	consequence	NN
cord-006860-a3b8hyyr	5056	15	of	of	IN
cord-006860-a3b8hyyr	5056	16	vascular	vascular	JJ
cord-006860-a3b8hyyr	5056	17	injury	injury	NN
cord-006860-a3b8hyyr	5056	18	,	,	,
cord-006860-a3b8hyyr	5056	19	leads	lead	VBZ
cord-006860-a3b8hyyr	5056	20	to	to	IN
cord-006860-a3b8hyyr	5056	21	TF	TF	NNP
cord-006860-a3b8hyyr	5056	22	/	/	SYM
cord-006860-a3b8hyyr	5056	23	F.VIIa	F.VIIa	NNP
cord-006860-a3b8hyyr	5056	24	-	-	HYPH
cord-006860-a3b8hyyr	5056	25	initiated	initiate	VBN
cord-006860-a3b8hyyr	5056	26	coagulation	coagulation	NN
cord-006860-a3b8hyyr	5056	27	which	which	WDT
cord-006860-a3b8hyyr	5056	28	may	may	MD
cord-006860-a3b8hyyr	5056	29	play	play	VB
cord-006860-a3b8hyyr	5056	30	a	a	DT
cord-006860-a3b8hyyr	5056	31	key	key	JJ
cord-006860-a3b8hyyr	5056	32	role	role	NN
cord-006860-a3b8hyyr	5056	33	in	in	IN
cord-006860-a3b8hyyr	5056	34	triggering	trigger	VBG
cord-006860-a3b8hyyr	5056	35	intravascular	intravascular	JJ
cord-006860-a3b8hyyr	5056	36	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	5056	37	.	.	.
cord-006860-a3b8hyyr	5057	1	In	in	IN
cord-006860-a3b8hyyr	5057	2	order	order	NN
cord-006860-a3b8hyyr	5057	3	to	to	TO
cord-006860-a3b8hyyr	5057	4	evaluate	evaluate	VB
cord-006860-a3b8hyyr	5057	5	the	the	DT
cord-006860-a3b8hyyr	5057	6	potential	potential	JJ
cord-006860-a3b8hyyr	5057	7	advantages	advantage	NNS
cord-006860-a3b8hyyr	5057	8	of	of	IN
cord-006860-a3b8hyyr	5057	9	TF	TF	NNP
cord-006860-a3b8hyyr	5057	10	pathway	pathway	NN
cord-006860-a3b8hyyr	5057	11	blockade	blockade	NN
cord-006860-a3b8hyyr	5057	12	over	over	IN
cord-006860-a3b8hyyr	5057	13	existing	exist	VBG
cord-006860-a3b8hyyr	5057	14	therapy	therapy	NN
cord-006860-a3b8hyyr	5057	15	,	,	,
cord-006860-a3b8hyyr	5057	16	the	the	DT
cord-006860-a3b8hyyr	5057	17	antithrombotic	antithrombotic	JJ
cord-006860-a3b8hyyr	5057	18	and	and	CC
cord-006860-a3b8hyyr	5057	19	the	the	DT
cord-006860-a3b8hyyr	5057	20	anticoagulant	anticoagulant	JJ
cord-006860-a3b8hyyr	5057	21	.effects	.effect	NNS
cord-006860-a3b8hyyr	5057	22	of	of	IN
cord-006860-a3b8hyyr	5057	23	a	a	DT
cord-006860-a3b8hyyr	5057	24	monoclonal	monoclonal	JJ
cord-006860-a3b8hyyr	5057	25	anti	anti	JJ
cord-006860-a3b8hyyr	5057	26	-	-	JJ
cord-006860-a3b8hyyr	5057	27	rabbit	rabbit	JJ
cord-006860-a3b8hyyr	5057	28	TF	TF	NNP
cord-006860-a3b8hyyr	5057	29	antibody	antibody	NN
cord-006860-a3b8hyyr	5057	30	(	(	-LRB-
cord-006860-a3b8hyyr	5057	31	AP-1	AP-1	NNP
cord-006860-a3b8hyyr	5057	32	)	)	-RRB-
cord-006860-a3b8hyyr	5057	33	and	and	CC
cord-006860-a3b8hyyr	5057	34	heparin	heparin	NN
cord-006860-a3b8hyyr	5057	35	were	be	VBD
cord-006860-a3b8hyyr	5057	36	compared	compare	VBN
cord-006860-a3b8hyyr	5057	37	in	in	IN
cord-006860-a3b8hyyr	5057	38	a	a	DT
cord-006860-a3b8hyyr	5057	39	rabbit	rabbit	NN
cord-006860-a3b8hyyr	5057	40	arterial	arterial	JJ
cord-006860-a3b8hyyr	5057	41	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	5057	42	model	model	NN
cord-006860-a3b8hyyr	5057	43	.	.	.
cord-006860-a3b8hyyr	5058	1	Thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	5058	2	was	be	VBD
cord-006860-a3b8hyyr	5058	3	induced	induce	VBN
cord-006860-a3b8hyyr	5058	4	by	by	IN
cord-006860-a3b8hyyr	5058	5	a	a	DT
cord-006860-a3b8hyyr	5058	6	local	local	JJ
cord-006860-a3b8hyyr	5058	7	injury	injury	NN
cord-006860-a3b8hyyr	5058	8	to	to	IN
cord-006860-a3b8hyyr	5058	9	the	the	DT
cord-006860-a3b8hyyr	5058	10	carotid	carotid	JJ
cord-006860-a3b8hyyr	5058	11	artery	artery	NN
cord-006860-a3b8hyyr	5058	12	and	and	CC
cord-006860-a3b8hyyr	5058	13	the	the	DT
cord-006860-a3b8hyyr	5058	14	recurrence	recurrence	NN
cord-006860-a3b8hyyr	5058	15	of	of	IN
cord-006860-a3b8hyyr	5058	16	thrombus	thrombus	NN
cord-006860-a3b8hyyr	5058	17	formation	formation	NN
cord-006860-a3b8hyyr	5058	18	was	be	VBD
cord-006860-a3b8hyyr	5058	19	followed	follow	VBN
cord-006860-a3b8hyyr	5058	20	by	by	IN
cord-006860-a3b8hyyr	5058	21	monitoring	monitor	VBG
cord-006860-a3b8hyyr	5058	22	the	the	DT
cord-006860-a3b8hyyr	5058	23	cyclic	cyclic	JJ
cord-006860-a3b8hyyr	5058	24	flow	flow	NN
cord-006860-a3b8hyyr	5058	25	variations	variation	NNS
cord-006860-a3b8hyyr	5058	26	(	(	-LRB-
cord-006860-a3b8hyyr	5058	27	CFV	CFV	NNP
cord-006860-a3b8hyyr	5058	28	)	)	-RRB-
cord-006860-a3b8hyyr	5058	29	of	of	IN
cord-006860-a3b8hyyr	5058	30	the	the	DT
cord-006860-a3b8hyyr	5058	31	arterial	arterial	JJ
cord-006860-a3b8hyyr	5058	32	blood	blood	NN
cord-006860-a3b8hyyr	5058	33	flow	flow	NN
cord-006860-a3b8hyyr	5058	34	.	.	.
cord-006860-a3b8hyyr	5059	1	Rabbits	rabbit	NNS
cord-006860-a3b8hyyr	5059	2	received	receive	VBD
cord-006860-a3b8hyyr	5059	3	intravenously	intravenously	RB
cord-006860-a3b8hyyr	5059	4	either	either	CC
cord-006860-a3b8hyyr	5059	5	AP-1	AP-1	NNP
cord-006860-a3b8hyyr	5059	6	,	,	,
cord-006860-a3b8hyyr	5059	7	heparin	heparin	NN
cord-006860-a3b8hyyr	5059	8	or	or	CC
cord-006860-a3b8hyyr	5059	9	vehicle	vehicle	NN
cord-006860-a3b8hyyr	5059	10	,	,	,
cord-006860-a3b8hyyr	5059	11	and	and	CC
cord-006860-a3b8hyyr	5059	12	CFV	CFV	NNP
cord-006860-a3b8hyyr	5059	13	were	be	VBD
cord-006860-a3b8hyyr	5059	14	monitored	monitor	VBN
cord-006860-a3b8hyyr	5059	15	on	on	IN
cord-006860-a3b8hyyr	5059	16	line	line	NN
cord-006860-a3b8hyyr	5059	17	for	for	IN
cord-006860-a3b8hyyr	5059	18	120	120	CD
cord-006860-a3b8hyyr	5059	19	min	min	NN
cord-006860-a3b8hyyr	5059	20	.	.	.
cord-006860-a3b8hyyr	5060	1	Activated	activate	VBN
cord-006860-a3b8hyyr	5060	2	partial	partial	JJ
cord-006860-a3b8hyyr	5060	3	thromboplastin	thromboplastin	NNP
cord-006860-a3b8hyyr	5060	4	time	time	NN
cord-006860-a3b8hyyr	5060	5	(	(	-LRB-
cord-006860-a3b8hyyr	5060	6	aPTT	aptt	NN
cord-006860-a3b8hyyr	5060	7	)	)	-RRB-
cord-006860-a3b8hyyr	5060	8	,	,	,
cord-006860-a3b8hyyr	5060	9	and	and	CC
cord-006860-a3b8hyyr	5060	10	activated	activate	VBN
cord-006860-a3b8hyyr	5060	11	clotting	clotting	NN
cord-006860-a3b8hyyr	5060	12	time	time	NN
cord-006860-a3b8hyyr	5061	1	(	(	-LRB-
cord-006860-a3b8hyyr	5061	2	ACT	ACT	NNP
cord-006860-a3b8hyyr	5061	3	)	)	-RRB-
cord-006860-a3b8hyyr	5061	4	were	be	VBD
cord-006860-a3b8hyyr	5061	5	measured	measure	VBN
cord-006860-a3b8hyyr	5061	6	at	at	IN
cord-006860-a3b8hyyr	5061	7	the	the	DT
cord-006860-a3b8hyyr	5061	8	end	end	NN
cord-006860-a3b8hyyr	5061	9	of	of	IN
cord-006860-a3b8hyyr	5061	10	the	the	DT
cord-006860-a3b8hyyr	5061	11	experiment	experiment	NN
cord-006860-a3b8hyyr	5061	12	control	control	NN
cord-006860-a3b8hyyr	5061	13	AP	AP	NNP
cord-006860-a3b8hyyr	5061	14	-	-	HYPH
cord-006860-a3b8hyyr	5061	15	I	I	NNP
cord-006860-a3b8hyyr	5062	1	heparin	heparin	NNP
cord-006860-a3b8hyyr	5062	2	<	<	XX
cord-006860-a3b8hyyr	5062	3	lmg	lmg	NNP
cord-006860-a3b8hyyr	5062	4	/	/	SYM
cord-006860-a3b8hyyr	5062	5	kg	kg	NNP
cord-006860-a3b8hyyr	5063	1	*	*	NFP
cord-006860-a3b8hyyr	5063	2	0.2mg	0.2mg	CD
cord-006860-a3b8hyyr	5063	3	/	/	SYM
cord-006860-a3b8hyyr	5063	4	kg/	kg/	XX
cord-006860-a3b8hyyr	5064	1	hr	hr	NNP
cord-006860-a3b8hyyr	5064	2	0.8	0.8	CD
cord-006860-a3b8hyyr	5064	3	mg	mg	NN
cord-006860-a3b8hyyr	5065	1	/kg	/kg	NFP
cord-006860-a3b8hyyr	5065	2	/	/	SYM
cord-006860-a3b8hyyr	5065	3	hr	hr	NN
cord-006860-a3b8hyyr	5065	4	intraabdominallretroperitoneal	intraabdominallretroperitoneal	NN
cord-006860-a3b8hyyr	5065	5	,	,	,
cord-006860-a3b8hyyr	5065	6	CNS	CNS	NNP
cord-006860-a3b8hyyr	5065	7	)	)	-RRB-
cord-006860-a3b8hyyr	5065	8	on	on	IN
cord-006860-a3b8hyyr	5065	9	a	a	DT
cord-006860-a3b8hyyr	5065	10	named	name	VBN
cord-006860-a3b8hyyr	5065	11	-	-	HYPH
cord-006860-a3b8hyyr	5065	12	patient	patient	NN
cord-006860-a3b8hyyr	5065	13	basis	basis	NN
cord-006860-a3b8hyyr	5065	14	.	.	.
cord-006860-a3b8hyyr	5066	1	Later	later	RBR
cord-006860-a3b8hyyr	5066	2	also	also	RB
cord-006860-a3b8hyyr	5066	3	mild	mild	JJ
cord-006860-a3b8hyyr	5066	4	/	/	SYM
cord-006860-a3b8hyyr	5066	5	moderate	moderate	JJ
cord-006860-a3b8hyyr	5066	6	bleeds	bleed	NNS
cord-006860-a3b8hyyr	5066	7	,	,	,
cord-006860-a3b8hyyr	5066	8	predominantly	predominantly	RB
cord-006860-a3b8hyyr	5066	9	joint	joint	JJ
cord-006860-a3b8hyyr	5066	10	bleeds	bleed	NNS
cord-006860-a3b8hyyr	5066	11	were	be	VBD
cord-006860-a3b8hyyr	5066	12	included	include	VBN
cord-006860-a3b8hyyr	5066	13	.	.	.
cord-006860-a3b8hyyr	5067	1	In	in	IN
cord-006860-a3b8hyyr	5067	2	80	80	CD
cord-006860-a3b8hyyr	5067	3	-	-	SYM
cord-006860-a3b8hyyr	5067	4	90	90	CD
cord-006860-a3b8hyyr	5067	5	%	%	NN
cord-006860-a3b8hyyr	5067	6	of	of	IN
cord-006860-a3b8hyyr	5067	7	the	the	DT
cord-006860-a3b8hyyr	5067	8	bleeds	bleed	NNS
cord-006860-a3b8hyyr	5067	9	NovoSeven	NovoSeven	NNP
cord-006860-a3b8hyyr	5067	10	was	be	VBD
cord-006860-a3b8hyyr	5067	11	found	find	VBN
cord-006860-a3b8hyyr	5067	12	to	to	TO
cord-006860-a3b8hyyr	5067	13	be	be	VB
cord-006860-a3b8hyyr	5067	14	hemostatically	hemostatically	RB
cord-006860-a3b8hyyr	5067	15	efficacious	efficacious	JJ
cord-006860-a3b8hyyr	5067	16	.	.	.
cord-006860-a3b8hyyr	5068	1	Also	also	RB
cord-006860-a3b8hyyr	5068	2	in	in	IN
cord-006860-a3b8hyyr	5068	3	major	major	JJ
cord-006860-a3b8hyyr	5068	4	surgery	surgery	NN
cord-006860-a3b8hyyr	5068	5	(	(	-LRB-
cord-006860-a3b8hyyr	5068	6	hip	hip	NN
cord-006860-a3b8hyyr	5068	7	-	-	HYPH
cord-006860-a3b8hyyr	5068	8	and	and	CC
cord-006860-a3b8hyyr	5068	9	knee	knee	NN
cord-006860-a3b8hyyr	5068	10	-	-	HYPH
cord-006860-a3b8hyyr	5068	11	replacement	replacement	NN
cord-006860-a3b8hyyr	5068	12	including	include	VBG
cord-006860-a3b8hyyr	5068	13	a	a	DT
cord-006860-a3b8hyyr	5068	14	bilateral	bilateral	JJ
cord-006860-a3b8hyyr	5068	15	total	total	JJ
cord-006860-a3b8hyyr	5068	16	condylar	condylar	JJ
cord-006860-a3b8hyyr	5068	17	arthroplasty	arthroplasty	NNP
cord-006860-a3b8hyyr	5068	18	,	,	,
cord-006860-a3b8hyyr	5068	19	herniotomy	herniotomy	NN
cord-006860-a3b8hyyr	5068	20	)	)	-RRB-
cord-006860-a3b8hyyr	5069	1	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	5069	2	efficacy	efficacy	NN
cord-006860-a3b8hyyr	5069	3	has	have	VBZ
cord-006860-a3b8hyyr	5069	4	been	be	VBN
cord-006860-a3b8hyyr	5069	5	found	find	VBN
cord-006860-a3b8hyyr	5069	6	to	to	TO
cord-006860-a3b8hyyr	5069	7	be	be	VB
cord-006860-a3b8hyyr	5069	8	94	94	CD
cord-006860-a3b8hyyr	5069	9	%	%	NN
cord-006860-a3b8hyyr	5069	10	Since	since	IN
cord-006860-a3b8hyyr	5069	11	rFVlla	rFVlla	NNP
cord-006860-a3b8hyyr	5069	12	is	be	VBZ
cord-006860-a3b8hyyr	5069	13	proteotytically	proteotytically	RB
cord-006860-a3b8hyyr	5069	14	active	active	JJ
cord-006860-a3b8hyyr	5069	15	only	only	RB
cord-006860-a3b8hyyr	5069	16	in	in	IN
cord-006860-a3b8hyyr	5069	17	complex	complex	NN
cord-006860-a3b8hyyr	5069	18	with	with	IN
cord-006860-a3b8hyyr	5069	19	TF	TF	NNP
cord-006860-a3b8hyyr	5070	1	the	the	DT
cord-006860-a3b8hyyr	5070	2	risk	risk	NN
cord-006860-a3b8hyyr	5070	3	for	for	IN
cord-006860-a3b8hyyr	5070	4	systemic	systemic	JJ
cord-006860-a3b8hyyr	5070	5	activation	activation	NN
cord-006860-a3b8hyyr	5070	6	of	of	IN
cord-006860-a3b8hyyr	5070	7	the	the	DT
cord-006860-a3b8hyyr	5070	8	coagulation	coagulation	NN
cord-006860-a3b8hyyr	5070	9	system	system	NN
cord-006860-a3b8hyyr	5070	10	should	should	MD
cord-006860-a3b8hyyr	5070	11	be	be	VB
cord-006860-a3b8hyyr	5070	12	minimal	minimal	JJ
cord-006860-a3b8hyyr	5070	13	.	.	.
cord-006860-a3b8hyyr	5071	1	Also	also	RB
cord-006860-a3b8hyyr	5071	2	very	very	RB
cord-006860-a3b8hyyr	5071	3	few	few	JJ
cord-006860-a3b8hyyr	5071	4	side	side	NN
cord-006860-a3b8hyyr	5071	5	-	-	HYPH
cord-006860-a3b8hyyr	5071	6	effects	effect	NNS
cord-006860-a3b8hyyr	5071	7	have	have	VBP
cord-006860-a3b8hyyr	5071	8	been	be	VBN
cord-006860-a3b8hyyr	5071	9	seen	see	VBN
cord-006860-a3b8hyyr	5071	10	.	.	.
cord-006860-a3b8hyyr	5072	1	Doses	dose	NNS
cord-006860-a3b8hyyr	5072	2	between	between	IN
cord-006860-a3b8hyyr	5072	3	75	75	CD
cord-006860-a3b8hyyr	5072	4	-	-	SYM
cord-006860-a3b8hyyr	5072	5	120	120	CD
cord-006860-a3b8hyyr	5072	6	tJg	tJg	NNS
cord-006860-a3b8hyyr	5072	7	/	/	SYM
cord-006860-a3b8hyyr	5072	8	kg	kg	NNS
cord-006860-a3b8hyyr	5072	9	have	have	VBP
cord-006860-a3b8hyyr	5072	10	been	be	VBN
cord-006860-a3b8hyyr	5072	11	used	use	VBN
cord-006860-a3b8hyyr	5072	12	,	,	,
cord-006860-a3b8hyyr	5072	13	which	which	WDT
cord-006860-a3b8hyyr	5072	14	initially	initially	RB
cord-006860-a3b8hyyr	5072	15	have	have	VBP
cord-006860-a3b8hyyr	5072	16	to	to	TO
cord-006860-a3b8hyyr	5072	17	be	be	VB
cord-006860-a3b8hyyr	5072	18	given	give	VBN
cord-006860-a3b8hyyr	5072	19	at	at	IN
cord-006860-a3b8hyyr	5072	20	2	2	CD
cord-006860-a3b8hyyr	5072	21	hours	hour	NNS
cord-006860-a3b8hyyr	5072	22	intervals	interval	NNS
cord-006860-a3b8hyyr	5072	23	.	.	.
cord-006860-a3b8hyyr	5073	1	To	to	TO
cord-006860-a3b8hyyr	5073	2	achieve	achieve	VB
cord-006860-a3b8hyyr	5073	3	satisfactory	satisfactory	JJ
cord-006860-a3b8hyyr	5073	4	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	5073	5	both	both	CC
cord-006860-a3b8hyyr	5073	6	an	an	DT
cord-006860-a3b8hyyr	5073	7	initial	initial	JJ
cord-006860-a3b8hyyr	5073	8	dose	dose	NN
cord-006860-a3b8hyyr	5073	9	high	high	JJ
cord-006860-a3b8hyyr	5073	10	enough	enough	RB
cord-006860-a3b8hyyr	5073	11	to	to	TO
cord-006860-a3b8hyyr	5073	12	induce	induce	VB
cord-006860-a3b8hyyr	5073	13	immediate	immediate	JJ
cord-006860-a3b8hyyr	5073	14	hemostasis	hemostasis	NN
cord-006860-a3b8hyyr	5073	15	AND	and	CC
cord-006860-a3b8hyyr	5073	16	an	an	DT
cord-006860-a3b8hyyr	5073	17	appropriate	appropriate	JJ
cord-006860-a3b8hyyr	5073	18	dose	dose	NN
cord-006860-a3b8hyyr	5073	19	interval	interval	NN
cord-006860-a3b8hyyr	5073	20	ensuring	ensure	VBG
cord-006860-a3b8hyyr	5073	21	a	a	DT
cord-006860-a3b8hyyr	5073	22	plasma	plasma	NN
cord-006860-a3b8hyyr	5073	23	level	level	NN
cord-006860-a3b8hyyr	5073	24	of	of	IN
cord-006860-a3b8hyyr	5073	25	FVlI	FVlI	NNS
cord-006860-a3b8hyyr	5073	26	:	:	:
cord-006860-a3b8hyyr	5074	1	C	C	NNP
cord-006860-a3b8hyyr	5074	2	well	well	RB
cord-006860-a3b8hyyr	5074	3	above	above	IN
cord-006860-a3b8hyyr	5074	4	the	the	DT
cord-006860-a3b8hyyr	5074	5	hemostatic	hemostatic	JJ
cord-006860-a3b8hyyr	5074	6	lower	low	JJR
cord-006860-a3b8hyyr	5074	7	level	level	NN
cord-006860-a3b8hyyr	5074	8	for	for	IN
cord-006860-a3b8hyyr	5074	9	a	a	DT
cord-006860-a3b8hyyr	5074	10	period	period	NN
cord-006860-a3b8hyyr	5074	11	of	of	IN
cord-006860-a3b8hyyr	5074	12	time	time	NN
cord-006860-a3b8hyyr	5074	13	,	,	,
cord-006860-a3b8hyyr	5074	14	the	the	DT
cord-006860-a3b8hyyr	5074	15	length	length	NN
cord-006860-a3b8hyyr	5074	16	of	of	IN
cord-006860-a3b8hyyr	5074	17	which	which	WDT
cord-006860-a3b8hyyr	5074	18	is	be	VBZ
cord-006860-a3b8hyyr	5074	19	dependent	dependent	JJ
cord-006860-a3b8hyyr	5074	20	on	on	IN
cord-006860-a3b8hyyr	5074	21	the	the	DT
cord-006860-a3b8hyyr	5074	22	type	type	NN
cord-006860-a3b8hyyr	5074	23	of	of	IN
cord-006860-a3b8hyyr	5074	24	bleeding	bleeding	NN
cord-006860-a3b8hyyr	5074	25	,	,	,
cord-006860-a3b8hyyr	5074	26	are	be	VBP
cord-006860-a3b8hyyr	5074	27	important	important	JJ
cord-006860-a3b8hyyr	5074	28	.	.	.
cord-006860-a3b8hyyr	5075	1	Accordingly	accordingly	RB
cord-006860-a3b8hyyr	5075	2	,	,	,
cord-006860-a3b8hyyr	5075	3	the	the	DT
cord-006860-a3b8hyyr	5075	4	highel	highel	NNP
cord-006860-a3b8hyyr	5075	5	the	the	DT
cord-006860-a3b8hyyr	5075	6	initial	initial	JJ
cord-006860-a3b8hyyr	5075	7	dose	dose	NN
cord-006860-a3b8hyyr	5075	8	the	the	DT
cord-006860-a3b8hyyr	5075	9	more	more	RBR
cord-006860-a3b8hyyr	5075	10	robust	robust	JJ
cord-006860-a3b8hyyr	5075	11	with	with	IN
cord-006860-a3b8hyyr	5075	12	regard	regard	NN
cord-006860-a3b8hyyr	5075	13	to	to	IN
cord-006860-a3b8hyyr	5075	14	dose	dose	NN
cord-006860-a3b8hyyr	5075	15	interval	interval	NN
cord-006860-a3b8hyyr	5075	16	will	will	MD
cord-006860-a3b8hyyr	5075	17	the	the	DT
cord-006860-a3b8hyyr	5075	18	treatment	treatment	NN
cord-006860-a3b8hyyr	5075	19	be	be	VB
cord-006860-a3b8hyyr	5075	20	.	.	.
cord-006860-a3b8hyyr	5076	1	Acute	acute	JJ
cord-006860-a3b8hyyr	5076	2	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	5076	3	ischemia	ischemia	NN
cord-006860-a3b8hyyr	5076	4	is	be	VBZ
cord-006860-a3b8hyyr	5076	5	usually	usually	RB
cord-006860-a3b8hyyr	5076	6	triggered	trigger	VBN
cord-006860-a3b8hyyr	5076	7	by	by	IN
cord-006860-a3b8hyyr	5076	8	coronary	coronary	JJ
cord-006860-a3b8hyyr	5076	9	thrombosis	thrombosis	NN
cord-006860-a3b8hyyr	5076	10	.	.	.
cord-006860-a3b8hyyr	5077	1	Heparin	Heparin	NNP
cord-006860-a3b8hyyr	5077	2	(	(	-LRB-
cord-006860-a3b8hyyr	5077	3	hep	hep	NNP
cord-006860-a3b8hyyr	5077	4	)	)	-RRB-
cord-006860-a3b8hyyr	5077	5	,	,	,
cord-006860-a3b8hyyr	5077	6	along	along	IN
cord-006860-a3b8hyyr	5077	7	with	with	IN
cord-006860-a3b8hyyr	5077	8	aspirin	aspirin	NN
cord-006860-a3b8hyyr	5077	9	,	,	,
cord-006860-a3b8hyyr	5077	10	is	be	VBZ
cord-006860-a3b8hyyr	5077	11	commonly	commonly	RB
cord-006860-a3b8hyyr	5077	12	used	use	VBN
cord-006860-a3b8hyyr	5077	13	for	for	IN
cord-006860-a3b8hyyr	5077	14	the	the	DT
cord-006860-a3b8hyyr	5077	15	treatment	treatment	NN
cord-006860-a3b8hyyr	5077	16	of	of	IN
cord-006860-a3b8hyyr	5077	17	unstable	unstable	JJ
cord-006860-a3b8hyyr	5077	18	angina	angina	NN
cord-006860-a3b8hyyr	5077	19	(	(	-LRB-
cord-006860-a3b8hyyr	5077	20	UA	UA	NNP
cord-006860-a3b8hyyr	5077	21	)	)	-RRB-
cord-006860-a3b8hyyr	5077	22	and	and	CC
cord-006860-a3b8hyyr	5077	23	myocardial	myocardial	JJ
cord-006860-a3b8hyyr	5077	24	infarction	infarction	NN
cord-006860-a3b8hyyr	5077	25	(	(	-LRB-
cord-006860-a3b8hyyr	5077	26	MI	MI	NNP
cord-006860-a3b8hyyr	5077	27	)	)	-RRB-
cord-006860-a3b8hyyr	5077	28	.	.	.
cord-006860-a3b8hyyr	5078	1	Hirudin	Hirudin	NNP
cord-006860-a3b8hyyr	5078	2	(	(	-LRB-
cord-006860-a3b8hyyr	5078	3	hiQ	hiq	NN
cord-006860-a3b8hyyr	5078	4	is	be	VBZ
cord-006860-a3b8hyyr	5078	5	a	a	DT
cord-006860-a3b8hyyr	5078	6	potent	potent	JJ
cord-006860-a3b8hyyr	5078	7	antitbrombin	antitbrombin	JJ
cord-006860-a3b8hyyr	5078	8	agent	agent	NN
cord-006860-a3b8hyyr	5078	9	which	which	WDT
cord-006860-a3b8hyyr	5078	10	may	may	MD
cord-006860-a3b8hyyr	5078	11	offer	offer	VB
cord-006860-a3b8hyyr	5078	12	therapeutic	therapeutic	JJ
cord-006860-a3b8hyyr	5078	13	advantages	advantage	NNS
cord-006860-a3b8hyyr	5078	14	over	over	IN
cord-006860-a3b8hyyr	5078	15	standard	standard	JJ
cord-006860-a3b8hyyr	5078	16	hep	hep	NN
cord-006860-a3b8hyyr	5078	17	for	for	IN
cord-006860-a3b8hyyr	5078	18	the	the	DT
cord-006860-a3b8hyyr	5078	19	treatment	treatment	NN
cord-006860-a3b8hyyr	5078	20	UA	UA	NNP
cord-006860-a3b8hyyr	5078	21	and	and	CC
cord-006860-a3b8hyyr	5078	22	MI	MI	NNP
cord-006860-a3b8hyyr	5078	23	.	.	.
cord-006860-a3b8hyyr	5079	1	The	the	DT
cord-006860-a3b8hyyr	5079	2	OASIS	OASIS	NNP
cord-006860-a3b8hyyr	5079	3	phase	phase	NN
cord-006860-a3b8hyyr	5080	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	5080	2	pilot	pilot	NN
cord-006860-a3b8hyyr	5080	3	study	study	NN
cord-006860-a3b8hyyr	5080	4	conducted	conduct	VBN
cord-006860-a3b8hyyr	5080	5	in	in	IN
cord-006860-a3b8hyyr	5080	6	24	24	CD
cord-006860-a3b8hyyr	5080	7	Canadian	canadian	JJ
cord-006860-a3b8hyyr	5080	8	centres	centre	NNS
cord-006860-a3b8hyyr	5080	9	,	,	,
cord-006860-a3b8hyyr	5080	10	has	have	VBZ
cord-006860-a3b8hyyr	5080	11	evaluated	evaluate	VBN
cord-006860-a3b8hyyr	5080	12	the	the	DT
cord-006860-a3b8hyyr	5080	13	safety	safety	NN
cord-006860-a3b8hyyr	5080	14	,	,	,
cord-006860-a3b8hyyr	5080	15	feasibility	feasibility	NN
cord-006860-a3b8hyyr	5080	16	and	and	CC
cord-006860-a3b8hyyr	5080	17	efficacy	efficacy	NN
cord-006860-a3b8hyyr	5080	18	of	of	IN
cord-006860-a3b8hyyr	5080	19	hir	hir	NNP
cord-006860-a3b8hyyr	5080	20	(	(	-LRB-
cord-006860-a3b8hyyr	5080	21	HBW	HBW	NNP
cord-006860-a3b8hyyr	5080	22	023	023	CD
cord-006860-a3b8hyyr	5080	23	,	,	,
cord-006860-a3b8hyyr	5080	24	Behringwerke	Behringwerke	NNP
cord-006860-a3b8hyyr	5080	25	AG	AG	NNP
cord-006860-a3b8hyyr	5080	26	,	,	,
cord-006860-a3b8hyyr	5080	27	Marburg	Marburg	NNP
cord-006860-a3b8hyyr	5080	28	)	)	-RRB-
cord-006860-a3b8hyyr	5080	29	compared	compare	VBN
cord-006860-a3b8hyyr	5080	30	to	to	IN
cord-006860-a3b8hyyr	5080	31	hep	hep	NN
cord-006860-a3b8hyyr	5080	32	in	in	IN
cord-006860-a3b8hyyr	5080	33	601	601	CD
cord-006860-a3b8hyyr	5080	34	patients	patient	NNS
cord-006860-a3b8hyyr	5080	35	with	with	IN
cord-006860-a3b8hyyr	5080	36	MI	MI	NNP
cord-006860-a3b8hyyr	5080	37	or	or	CC
cord-006860-a3b8hyyr	5080	38	suspected	suspect	VBN
cord-006860-a3b8hyyr	5080	39	non	non	FW
cord-006860-a3b8hyyr	5080	40	Q	q	NN
cord-006860-a3b8hyyr	5080	41	-	-	HYPH
cord-006860-a3b8hyyr	5080	42	wave	wave	NN
cord-006860-a3b8hyyr	5080	43	MI	MI	NNP
cord-006860-a3b8hyyr	5080	44	.	.	.
cord-006860-a3b8hyyr	5081	1	Patients	patient	NNS
cord-006860-a3b8hyyr	5081	2	(	(	-LRB-
cord-006860-a3b8hyyr	5081	3	95	95	CD
cord-006860-a3b8hyyr	5081	4	%	%	NN
cord-006860-a3b8hyyr	5081	5	received	receive	VBD
cord-006860-a3b8hyyr	5081	6	aspirin	aspirin	NN
cord-006860-a3b8hyyr	5081	7	)	)	-RRB-
cord-006860-a3b8hyyr	5081	8	were	be	VBD
cord-006860-a3b8hyyr	5081	9	randomized	randomize	VBN
cord-006860-a3b8hyyr	5081	10	to	to	IN
cord-006860-a3b8hyyr	5081	11	a	a	DT
cord-006860-a3b8hyyr	5081	12	72	72	CD
cord-006860-a3b8hyyr	5081	13	hr	hr	NN
cord-006860-a3b8hyyr	5081	14	infusion	infusion	NN
cord-006860-a3b8hyyr	5081	15	of	of	IN
cord-006860-a3b8hyyr	5081	16	either	either	CC
cord-006860-a3b8hyyr	5081	17	hep	hep	NNP
cord-006860-a3b8hyyr	5081	18	(	(	-LRB-
cord-006860-a3b8hyyr	5081	19	5000	5000	CD
cord-006860-a3b8hyyr	5081	20	u	u	NNP
cord-006860-a3b8hyyr	5081	21	bolus	bolus	NN
cord-006860-a3b8hyyr	5081	22	followed	follow	VBD
cord-006860-a3b8hyyr	5081	23	by	by	IN
cord-006860-a3b8hyyr	5081	24	1200	1200	CD
cord-006860-a3b8hyyr	5081	25	u	u	NNP
cord-006860-a3b8hyyr	5081	26	/	/	SYM
cord-006860-a3b8hyyr	5081	27	hr	hr	NN
cord-006860-a3b8hyyr	5081	28	;	;	:
cord-006860-a3b8hyyr	5081	29	n=253	n=253	NNP
cord-006860-a3b8hyyr	5081	30	)	)	-RRB-
cord-006860-a3b8hyyr	5081	31	,	,	,
cord-006860-a3b8hyyr	5081	32	or	or	CC
cord-006860-a3b8hyyr	5081	33	low	low	JJ
cord-006860-a3b8hyyr	5081	34	dose	dose	NN
cord-006860-a3b8hyyr	5081	35	hir	hir	NNP
cord-006860-a3b8hyyr	5081	36	(	(	-LRB-
cord-006860-a3b8hyyr	5081	37	0.2	0.2	CD
cord-006860-a3b8hyyr	5081	38	mg	mg	NNP
cord-006860-a3b8hyyr	5081	39	/	/	SYM
cord-006860-a3b8hyyr	5081	40	kg	kg	NN
cord-006860-a3b8hyyr	5081	41	bolus	bolus	NN
cord-006860-a3b8hyyr	5082	1	then	then	RB
cord-006860-a3b8hyyr	5082	2	0.10	0.10	CD
cord-006860-a3b8hyyr	5082	3	mg	mg	NNP
cord-006860-a3b8hyyr	5082	4	/	/	SYM
cord-006860-a3b8hyyr	5082	5	kg	kg	NNP
cord-006860-a3b8hyyr	5082	6	/	/	SYM
cord-006860-a3b8hyyr	5082	7	hr	hr	NN
cord-006860-a3b8hyyr	5082	8	;	;	:
cord-006860-a3b8hyyr	5082	9	n=175	n=175	NNP
cord-006860-a3b8hyyr	5082	10	)	)	-RRB-
cord-006860-a3b8hyyr	5082	11	or	or	CC
cord-006860-a3b8hyyr	5082	12	medium	medium	JJ
cord-006860-a3b8hyyr	5082	13	dose	dose	NN
cord-006860-a3b8hyyr	5082	14	lair	lair	NN
cord-006860-a3b8hyyr	5082	15	(	(	-LRB-
cord-006860-a3b8hyyr	5082	16	0.4	0.4	CD
cord-006860-a3b8hyyr	5082	17	ms	ms	NNP
cord-006860-a3b8hyyr	5082	18	/	/	SYM
cord-006860-a3b8hyyr	5082	19	ks	ks	NNP
cord-006860-a3b8hyyr	5083	1	bolus	bolus	NNP
cord-006860-a3b8hyyr	5083	2	then	then	RB
cord-006860-a3b8hyyr	5083	3	0.15	0.15	CD
cord-006860-a3b8hyyr	5083	4	mg	mg	NNP
cord-006860-a3b8hyyr	5083	5	/	/	SYM
cord-006860-a3b8hyyr	5083	6	kg	kg	NNP
cord-006860-a3b8hyyr	5083	7	/	/	SYM
cord-006860-a3b8hyyr	5083	8	hr	hr	NN
cord-006860-a3b8hyyr	5083	9	;	;	:
cord-006860-a3b8hyyr	5083	10	n=173	n=173	ADD
cord-006860-a3b8hyyr	5083	11	)	)	-RRB-
cord-006860-a3b8hyyr	5083	12	.	.	.
cord-006860-a3b8hyyr	5084	1	At	at	IN
cord-006860-a3b8hyyr	5084	2	seven	seven	CD
cord-006860-a3b8hyyr	5084	3	days	day	NNS
cord-006860-a3b8hyyr	5084	4	of	of	IN
cord-006860-a3b8hyyr	5084	5	follow	follow	NN
cord-006860-a3b8hyyr	5084	6	-	-	HYPH
cord-006860-a3b8hyyr	5084	7	up	up	NN
cord-006860-a3b8hyyr	5084	8	the	the	DT
cord-006860-a3b8hyyr	5084	9	incidence	incidence	NN
cord-006860-a3b8hyyr	5084	10	of	of	IN
cord-006860-a3b8hyyr	5084	11	major	major	JJ
cord-006860-a3b8hyyr	5084	12	bleeds	bleed	NNS
cord-006860-a3b8hyyr	5084	13	was	be	VBD
cord-006860-a3b8hyyr	5084	14	0.4	0.4	CD
cord-006860-a3b8hyyr	5084	15	%	%	NN
cord-006860-a3b8hyyr	5084	16	in	in	IN
cord-006860-a3b8hyyr	5084	17	the	the	DT
cord-006860-a3b8hyyr	5084	18	heparin	heparin	NNP
cord-006860-a3b8hyyr	5084	19	group	group	NN
cord-006860-a3b8hyyr	5084	20	,	,	,
cord-006860-a3b8hyyr	5084	21	0.6	0.6	CD
cord-006860-a3b8hyyr	5084	22	%	%	NN
cord-006860-a3b8hyyr	5084	23	low	low	JJ
cord-006860-a3b8hyyr	5084	24	dose	dose	NN
cord-006860-a3b8hyyr	5084	25	hit	hit	NN
cord-006860-a3b8hyyr	5084	26	,	,	,
cord-006860-a3b8hyyr	5084	27	1.2	1.2	CD
cord-006860-a3b8hyyr	5084	28	%	%	NN
cord-006860-a3b8hyyr	5084	29	medium	medium	NN
cord-006860-a3b8hyyr	5084	30	dose	dose	NN
cord-006860-a3b8hyyr	5084	31	lair	lair	NN
cord-006860-a3b8hyyr	5084	32	(	(	-LRB-
cord-006860-a3b8hyyr	5084	33	p	p	NN
cord-006860-a3b8hyyr	5084	34	=	=	SYM
cord-006860-a3b8hyyr	5084	35	NS	NS	NNP
cord-006860-a3b8hyyr	5084	36	)	)	-RRB-
cord-006860-a3b8hyyr	5084	37	,	,	,
cord-006860-a3b8hyyr	5084	38	minor	minor	JJ
cord-006860-a3b8hyyr	5084	39	bleeds	bleed	NNS
cord-006860-a3b8hyyr	5084	40	were	be	VBD
cord-006860-a3b8hyyr	5084	41	10.3	10.3	CD
cord-006860-a3b8hyyr	5084	42	%	%	NN
cord-006860-a3b8hyyr	5084	43	,	,	,
cord-006860-a3b8hyyr	5084	44	17.1	17.1	CD
cord-006860-a3b8hyyr	5084	45	%	%	NN
cord-006860-a3b8hyyr	5084	46	and	and	CC
cord-006860-a3b8hyyr	5084	47	19.1	19.1	CD
cord-006860-a3b8hyyr	5084	48	%	%	NN
cord-006860-a3b8hyyr	5084	49	respectively	respectively	RB
cord-006860-a3b8hyyr	5084	50	(	(	-LRB-
cord-006860-a3b8hyyr	5084	51	p---0.008	p---0.008	NNP
cord-006860-a3b8hyyr	5084	52	hep	hep	NNP
cord-006860-a3b8hyyr	5084	53	vs	vs	IN
cord-006860-a3b8hyyr	5084	54	med	med	JJ
cord-006860-a3b8hyyr	5084	55	dose	dose	NN
cord-006860-a3b8hyyr	5084	56	)	)	-RRB-
cord-006860-a3b8hyyr	5084	57	;	;	:
cord-006860-a3b8hyyr	5084	58	there	there	EX
cord-006860-a3b8hyyr	5084	59	were	be	VBD
cord-006860-a3b8hyyr	5084	60	no	no	DT
cord-006860-a3b8hyyr	5084	61	hemorrhagic	hemorrhagic	JJ
cord-006860-a3b8hyyr	5084	62	strokes	stroke	NNS
cord-006860-a3b8hyyr	5084	63	.	.	.
cord-006860-a3b8hyyr	5085	1	The	the	DT
cord-006860-a3b8hyyr	5085	2	incidence	incidence	NN
cord-006860-a3b8hyyr	5085	3	of	of	IN
cord-006860-a3b8hyyr	5085	4	the	the	DT
cord-006860-a3b8hyyr	5085	5	primary	primary	JJ
cord-006860-a3b8hyyr	5085	6	outcome	outcome	NN
cord-006860-a3b8hyyr	5085	7	of	of	IN
cord-006860-a3b8hyyr	5085	8	cardiovascular	cardiovascular	JJ
cord-006860-a3b8hyyr	5085	9	death	death	NN
cord-006860-a3b8hyyr	5085	10	,	,	,
cord-006860-a3b8hyyr	5085	11	new	new	JJ
cord-006860-a3b8hyyr	5085	12	MI	MI	NNP
cord-006860-a3b8hyyr	5085	13	and	and	CC
cord-006860-a3b8hyyr	5085	14	severe	severe	JJ
cord-006860-a3b8hyyr	5085	15	recurrent	recurrent	JJ
cord-006860-a3b8hyyr	5085	16	ischemia	ischemia	NN
cord-006860-a3b8hyyr	5085	17	(	(	-LRB-
cord-006860-a3b8hyyr	5085	18	refractory	refractory	JJ
cord-006860-a3b8hyyr	5085	19	or	or	CC
cord-006860-a3b8hyyr	5085	20	severe	severe	JJ
cord-006860-a3b8hyyr	5085	21	angina	angina	NN
cord-006860-a3b8hyyr	5085	22	)	)	-RRB-
cord-006860-a3b8hyyr	5085	23	was	be	VBD
cord-006860-a3b8hyyr	5085	24	17.0	17.0	CD
cord-006860-a3b8hyyr	5085	25	%	%	NN
cord-006860-a3b8hyyr	5085	26	,	,	,
cord-006860-a3b8hyyr	5085	27	15.4	15.4	CD
cord-006860-a3b8hyyr	5085	28	%	%	NN
cord-006860-a3b8hyyr	5085	29	and	and	CC
cord-006860-a3b8hyyr	5085	30	8.7	8.7	CD
cord-006860-a3b8hyyr	5085	31	%	%	NN
cord-006860-a3b8hyyr	5085	32	respectively	respectively	RB
cord-006860-a3b8hyyr	5085	33	(	(	-LRB-
cord-006860-a3b8hyyr	5085	34	p---0.014	p---0.014	NNP
cord-006860-a3b8hyyr	5085	35	hep	hep	NNP
cord-006860-a3b8hyyr	5085	36	vs	vs	IN
cord-006860-a3b8hyyr	5085	37	reed	reed	NNP
cord-006860-a3b8hyyr	5085	38	dose	dose	NN
cord-006860-a3b8hyyr	5085	39	)	)	-RRB-
cord-006860-a3b8hyyr	5085	40	.	.	.
cord-006860-a3b8hyyr	5086	1	There	there	EX
cord-006860-a3b8hyyr	5086	2	was	be	VBD
cord-006860-a3b8hyyr	5086	3	also	also	RB
cord-006860-a3b8hyyr	5086	4	a	a	DT
cord-006860-a3b8hyyr	5086	5	trend	trend	NN
cord-006860-a3b8hyyr	5086	6	towards	towards	IN
cord-006860-a3b8hyyr	5086	7	lower	low	JJR
cord-006860-a3b8hyyr	5086	8	rates	rate	NNS
cord-006860-a3b8hyyr	5086	9	of	of	IN
cord-006860-a3b8hyyr	5086	10	coronary	coronary	JJ
cord-006860-a3b8hyyr	5086	11	artery	artery	NN
cord-006860-a3b8hyyr	5086	12	bypass	bypass	NN
cord-006860-a3b8hyyr	5086	13	surgery	surgery	NN
cord-006860-a3b8hyyr	5086	14	in	in	IN
cord-006860-a3b8hyyr	5086	15	reed	reed	NN
cord-006860-a3b8hyyr	5086	16	dose	dose	NN
cord-006860-a3b8hyyr	5086	17	hir	hir	NNP
cord-006860-a3b8hyyr	5086	18	compared	compare	VBN
cord-006860-a3b8hyyr	5086	19	to	to	IN
cord-006860-a3b8hyyr	5086	20	hep	hep	NNP
cord-006860-a3b8hyyr	5086	21	.	.	.
cord-006860-a3b8hyyr	5087	1	In	in	IN
cord-006860-a3b8hyyr	5087	2	a	a	DT
cord-006860-a3b8hyyr	5087	3	200	200	CD
cord-006860-a3b8hyyr	5087	4	patient	patient	JJ
cord-006860-a3b8hyyr	5087	5	substudy	substudy	NN
cord-006860-a3b8hyyr	5087	6	,	,	,
cord-006860-a3b8hyyr	5087	7	levels	level	NNS
cord-006860-a3b8hyyr	5087	8	of	of	IN
cord-006860-a3b8hyyr	5087	9	thrombin	thrombin	JJ
cord-006860-a3b8hyyr	5087	10	antithrombin	antithrombin	NN
cord-006860-a3b8hyyr	5087	11	complex	complex	NN
cord-006860-a3b8hyyr	5087	12	,	,	,
cord-006860-a3b8hyyr	5087	13	fibfinopeptide	fibfinopeptide	VB
cord-006860-a3b8hyyr	5087	14	A	a	NN
cord-006860-a3b8hyyr	5087	15	and	and	CC
cord-006860-a3b8hyyr	5087	16	D	d	NN
cord-006860-a3b8hyyr	5087	17	-	-	HYPH
cord-006860-a3b8hyyr	5087	18	dimer	dimer	NN
cord-006860-a3b8hyyr	5087	19	were	be	VBD
cord-006860-a3b8hyyr	5087	20	all	all	RB
cord-006860-a3b8hyyr	5087	21	suppressed	suppress	VBN
cord-006860-a3b8hyyr	5087	22	to	to	IN
cord-006860-a3b8hyyr	5087	23	a	a	DT
cord-006860-a3b8hyyr	5087	24	greater	great	JJR
cord-006860-a3b8hyyr	5087	25	extent	extent	NN
cord-006860-a3b8hyyr	5087	26	by	by	IN
cord-006860-a3b8hyyr	5087	27	Mr	Mr	NNP
cord-006860-a3b8hyyr	5087	28	compared	compare	VBN
cord-006860-a3b8hyyr	5087	29	to	to	IN
cord-006860-a3b8hyyr	5087	30	hep	hep	NNP
cord-006860-a3b8hyyr	5087	31	.	.	.
cord-006860-a3b8hyyr	5088	1	These	these	DT
cord-006860-a3b8hyyr	5088	2	results	result	NNS
cord-006860-a3b8hyyr	5088	3	indicate	indicate	VBP
cord-006860-a3b8hyyr	5088	4	that	that	IN
cord-006860-a3b8hyyr	5088	5	hirudin	hirudin	NN
cord-006860-a3b8hyyr	5088	6	may	may	MD
cord-006860-a3b8hyyr	5088	7	be	be	VB
cord-006860-a3b8hyyr	5088	8	a	a	DT
cord-006860-a3b8hyyr	5088	9	more	more	RBR
cord-006860-a3b8hyyr	5088	10	effective	effective	JJ
cord-006860-a3b8hyyr	5088	11	agent	agent	NN
cord-006860-a3b8hyyr	5088	12	for	for	IN
cord-006860-a3b8hyyr	5088	13	the	the	DT
cord-006860-a3b8hyyr	5088	14	treatment	treatment	NN
cord-006860-a3b8hyyr	5088	15	of	of	IN
cord-006860-a3b8hyyr	5088	16	acute	acute	JJ
cord-006860-a3b8hyyr	5088	17	coronary	coronary	JJ
cord-006860-a3b8hyyr	5088	18	syndromes	syndrome	NNS
cord-006860-a3b8hyyr	5088	19	,	,	,
cord-006860-a3b8hyyr	5088	20	but	but	CC
cord-006860-a3b8hyyr	5088	21	more	more	JJR
cord-006860-a3b8hyyr	5088	22	information	information	NN
cord-006860-a3b8hyyr	5088	23	on	on	IN
cord-006860-a3b8hyyr	5088	24	safety	safety	NN
cord-006860-a3b8hyyr	5088	25	and	and	CC
cord-006860-a3b8hyyr	5088	26	efficacy	efficacy	NN
cord-006860-a3b8hyyr	5088	27	is	be	VBZ
cord-006860-a3b8hyyr	5088	28	needed	need	VBN
cord-006860-a3b8hyyr	5088	29	from	from	IN
cord-006860-a3b8hyyr	5088	30	larger	large	JJR
cord-006860-a3b8hyyr	5088	31	randomized	randomized	JJ
cord-006860-a3b8hyyr	5088	32	trials	trial	NNS
cord-006860-a3b8hyyr	5088	33	.	.	.
cord-006860-a3b8hyyr	5089	1	Full	full	JJ
cord-006860-a3b8hyyr	5089	2	clinical	clinical	JJ
cord-006860-a3b8hyyr	5089	3	and	and	CC
cord-006860-a3b8hyyr	5089	4	coagulation	coagulation	NN
cord-006860-a3b8hyyr	5089	5	resuks	resuks	NN
cord-006860-a3b8hyyr	5089	6	will	will	MD
cord-006860-a3b8hyyr	5089	7	be	be	VB
cord-006860-a3b8hyyr	5089	8	presented	present	VBN
cord-006860-a3b8hyyr	5089	9	.	.	.
cord-006860-a3b8hyyr	5090	1	HAT	hat	NN
cord-006860-a3b8hyyr	5090	2	is	be	VBZ
cord-006860-a3b8hyyr	5090	3	caused	cause	VBN
cord-006860-a3b8hyyr	5090	4	by	by	IN
cord-006860-a3b8hyyr	5090	5	an	an	DT
cord-006860-a3b8hyyr	5090	6	immunologic	immunologic	JJ
cord-006860-a3b8hyyr	5090	7	response	response	NN
cord-006860-a3b8hyyr	5090	8	to	to	IN
cord-006860-a3b8hyyr	5090	9	heparin	heparin	NN
cord-006860-a3b8hyyr	5090	10	.	.	.
cord-006860-a3b8hyyr	5091	1	Affected	affected	JJ
cord-006860-a3b8hyyr	5091	2	patients	patient	NNS
cord-006860-a3b8hyyr	5091	3	need	need	VBP
cord-006860-a3b8hyyr	5091	4	effective	effective	JJ
cord-006860-a3b8hyyr	5091	5	parenteral	parenteral	JJ
cord-006860-a3b8hyyr	5091	6	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	5091	7	.	.	.
cord-006860-a3b8hyyr	5092	1	We	-PRON-	PRP
cord-006860-a3b8hyyr	5092	2	treated	treat	VBD
cord-006860-a3b8hyyr	5092	3	82	82	CD
cord-006860-a3b8hyyr	5092	4	patients	patient	NNS
cord-006860-a3b8hyyr	5092	5	(	(	-LRB-
cord-006860-a3b8hyyr	5092	6	30m,52fm	30m,52fm	CD
cord-006860-a3b8hyyr	5092	7	)	)	-RRB-
cord-006860-a3b8hyyr	5092	8	,	,	,
cord-006860-a3b8hyyr	5092	9	median	median	JJ
cord-006860-a3b8hyyr	5092	10	age	age	NN
cord-006860-a3b8hyyr	5092	11	61	61	CD
cord-006860-a3b8hyyr	5092	12	years	year	NNS
cord-006860-a3b8hyyr	5092	13	(	(	-LRB-
cord-006860-a3b8hyyr	5092	14	18	18	CD
cord-006860-a3b8hyyr	5092	15	-	-	SYM
cord-006860-a3b8hyyr	5092	16	84	84	CD
cord-006860-a3b8hyyr	5092	17	)	)	-RRB-
cord-006860-a3b8hyyr	5092	18	with	with	IN
cord-006860-a3b8hyyr	5092	19	laboratory	laboratory	NN
cord-006860-a3b8hyyr	5092	20	confirmed	confirm	VBD
cord-006860-a3b8hyyr	5092	21	HAT	hat	NN
cord-006860-a3b8hyyr	5092	22	(	(	-LRB-
cord-006860-a3b8hyyr	5092	23	HIPA	HIPA	NNP
cord-006860-a3b8hyyr	5092	24	-	-	HYPH
cord-006860-a3b8hyyr	5092	25	Test	Test	NNP
cord-006860-a3b8hyyr	5092	26	)	)	-RRB-
cord-006860-a3b8hyyr	5093	1	with	with	IN
cord-006860-a3b8hyyr	5093	2	r	r	NN
cord-006860-a3b8hyyr	5093	3	-	-	:
cord-006860-a3b8hyyr	5093	4	hirudin	hirudin	NN
cord-006860-a3b8hyyr	5093	5	(	(	-LRB-
cord-006860-a3b8hyyr	5093	6	Behringwcrke	Behringwcrke	NNP
cord-006860-a3b8hyyr	5093	7	AG	AG	NNP
cord-006860-a3b8hyyr	5093	8	,	,	,
cord-006860-a3b8hyyr	5093	9	Marburg	Marburg	NNP
cord-006860-a3b8hyyr	5093	10	)	)	-RRB-
cord-006860-a3b8hyyr	5093	11	.	.	.
cord-006860-a3b8hyyr	5094	1	Treatment	treatment	NN
cord-006860-a3b8hyyr	5094	2	regimens	regimen	NNS
cord-006860-a3b8hyyr	5094	3	were	be	VBD
cord-006860-a3b8hyyr	5094	4	:	:	:
cord-006860-a3b8hyyr	5094	5	AI	AI	NNP
cord-006860-a3b8hyyr	5094	6	acute	acute	JJ
cord-006860-a3b8hyyr	5094	7	HAT	hat	NN
cord-006860-a3b8hyyr	5094	8	:	:	:
cord-006860-a3b8hyyr	5095	1	0.4	0.4	CD
cord-006860-a3b8hyyr	5095	2	mg	mg	NN
cord-006860-a3b8hyyr	5095	3	/	/	SYM
cord-006860-a3b8hyyr	5095	4	kg	kg	NNP
cord-006860-a3b8hyyr	5096	1	b.w	b.w	NNP
cord-006860-a3b8hyyr	5096	2	.	.	.
cord-006860-a3b8hyyr	5097	1	,	,	,
cord-006860-a3b8hyyr	5097	2	continuous	continuous	JJ
cord-006860-a3b8hyyr	5097	3	infusion	infusion	NN
cord-006860-a3b8hyyr	5097	4	0A5	0a5	CD
cord-006860-a3b8hyyr	5097	5	mg	mg	NN
cord-006860-a3b8hyyr	5098	1	/kg	/kg	NFP
cord-006860-a3b8hyyr	5098	2	b.w	b.w	NNP
cord-006860-a3b8hyyr	5098	3	/	/	SYM
cord-006860-a3b8hyyr	5098	4	h	h	NN
cord-006860-a3b8hyyr	5098	5	(	(	-LRB-
cord-006860-a3b8hyyr	5098	6	51	51	CD
cord-006860-a3b8hyyr	5098	7	patients	patient	NNS
cord-006860-a3b8hyyr	5098	8	)	)	-RRB-
cord-006860-a3b8hyyr	5098	9	;	;	:
cord-006860-a3b8hyyr	5098	10	A2	A2	NNP
cord-006860-a3b8hyyr	5098	11	acute	acute	JJ
cord-006860-a3b8hyyr	5098	12	HAT	hat	NN
cord-006860-a3b8hyyr	5098	13	with	with	IN
cord-006860-a3b8hyyr	5098	14	thrombolysis	thrombolysis	NN
cord-006860-a3b8hyyr	5098	15	:	:	:
cord-006860-a3b8hyyr	5098	16	bolus	bolus	NN
cord-006860-a3b8hyyr	5099	1	0.2	0.2	CD
cord-006860-a3b8hyyr	5099	2	mg	mg	NNP
cord-006860-a3b8hyyr	5099	3	/	/	SYM
cord-006860-a3b8hyyr	5099	4	kg	kg	NNP
cord-006860-a3b8hyyr	5099	5	b.w	b.w	NNP
cord-006860-a3b8hyyr	5099	6	.	.	.
cord-006860-a3b8hyyr	5100	1	,	,	,
cord-006860-a3b8hyyr	5100	2	continuous	continuous	JJ
cord-006860-a3b8hyyr	5100	3	infusion	infusion	NN
cord-006860-a3b8hyyr	5100	4	0.1	0.1	CD
cord-006860-a3b8hyyr	5100	5	mg	mg	NNP
cord-006860-a3b8hyyr	5100	6	/	/	SYM
cord-006860-a3b8hyyr	5100	7	kg	kg	NNP
cord-006860-a3b8hyyr	5100	8	b.w./h	b.w./h	NNP
cord-006860-a3b8hyyr	5100	9	(	(	-LRB-
cord-006860-a3b8hyyr	5100	10	5	5	CD
cord-006860-a3b8hyyr	5100	11	patients	patient	NNS
cord-006860-a3b8hyyr	5100	12	)	)	-RRB-
cord-006860-a3b8hyyr	5100	13	;	;	:
cord-006860-a3b8hyyr	5101	1	B	b	NN
cord-006860-a3b8hyyr	5101	2	:	:	:
cord-006860-a3b8hyyr	5101	3	proph	proph	NNP
cord-006860-a3b8hyyr	5101	4	,	,	,
cord-006860-a3b8hyyr	5101	5	treatment	treatment	NN
cord-006860-a3b8hyyr	5101	6	:	:	:
cord-006860-a3b8hyyr	5101	7	continuous	continuous	JJ
cord-006860-a3b8hyyr	5101	8	infusion	infusion	NN
cord-006860-a3b8hyyr	5101	9	0	0	CD
cord-006860-a3b8hyyr	5101	10	.	.	.
cord-006860-a3b8hyyr	5102	1	I	-PRON-	PRP
cord-006860-a3b8hyyr	5103	1	mg	mg	NNP
cord-006860-a3b8hyyr	5103	2	/	/	SYM
cord-006860-a3b8hyyr	5103	3	kg	kg	NNP
cord-006860-a3b8hyyr	5103	4	b.w	b.w	NNP
cord-006860-a3b8hyyr	5103	5	.	.	.
cord-006860-a3b8hyyr	5103	6	Pa	Pa	NNP
cord-006860-a3b8hyyr	5103	7	(	(	-LRB-
cord-006860-a3b8hyyr	5103	8	18	18	CD
cord-006860-a3b8hyyr	5103	9	patients	patient	NNS
cord-006860-a3b8hyyr	5103	10	)	)	-RRB-
cord-006860-a3b8hyyr	5103	11	;	;	:
cord-006860-a3b8hyyr	5103	12	C	C	NNP
cord-006860-a3b8hyyr	5103	13	:	:	:
cord-006860-a3b8hyyr	5103	14	during	during	IN
cord-006860-a3b8hyyr	5103	15	cardio	cardio	JJ
cord-006860-a3b8hyyr	5103	16	-	-	HYPH
cord-006860-a3b8hyyr	5103	17	pulmunary	pulmunary	JJ
cord-006860-a3b8hyyr	5103	18	bypass	bypass	NN
cord-006860-a3b8hyyr	5103	19	.	.	.
cord-006860-a3b8hyyr	5104	1	Primary	primary	JJ
cord-006860-a3b8hyyr	5104	2	objective	objective	NN
cord-006860-a3b8hyyr	5104	3	was	be	VBD
cord-006860-a3b8hyyr	5104	4	:	:	:
cord-006860-a3b8hyyr	5104	5	increase	increase	VB
cord-006860-a3b8hyyr	5104	6	in	in	IN
cord-006860-a3b8hyyr	5104	7	platelet	platelet	NN
cord-006860-a3b8hyyr	5104	8	counts	count	NNS
cord-006860-a3b8hyyr	5104	9	or	or	CC
cord-006860-a3b8hyyr	5104	10	maintenance	maintenance	NN
cord-006860-a3b8hyyr	5104	11	of	of	IN
cord-006860-a3b8hyyr	5104	12	normal	normal	JJ
cord-006860-a3b8hyyr	5104	13	baseline	baseline	JJ
cord-006860-a3b8hyyr	5104	14	values	value	NNS
cord-006860-a3b8hyyr	5104	15	during	during	IN
cord-006860-a3b8hyyr	5104	16	effective	effective	JJ
cord-006860-a3b8hyyr	5104	17	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	5104	18	.	.	.
cord-006860-a3b8hyyr	5105	1	Secondary	secondary	JJ
cord-006860-a3b8hyyr	5105	2	objectives	objective	NNS
cord-006860-a3b8hyyr	5105	3	were	be	VBD
cord-006860-a3b8hyyr	5105	4	the	the	DT
cord-006860-a3b8hyyr	5105	5	incidence	incidence	NN
cord-006860-a3b8hyyr	5105	6	of	of	IN
cord-006860-a3b8hyyr	5105	7	new	new	JJ
cord-006860-a3b8hyyr	5105	8	thromboembolic	thromboembolic	JJ
cord-006860-a3b8hyyr	5105	9	complications	complication	NNS
cord-006860-a3b8hyyr	5105	10	(	(	-LRB-
cord-006860-a3b8hyyr	5105	11	TECs	TECs	NNP
cord-006860-a3b8hyyr	5105	12	)	)	-RRB-
cord-006860-a3b8hyyr	5105	13	,	,	,
cord-006860-a3b8hyyr	5105	14	major	major	JJ
cord-006860-a3b8hyyr	5105	15	hemorrhage	hemorrhage	NN
cord-006860-a3b8hyyr	5105	16	,	,	,
cord-006860-a3b8hyyr	5105	17	limb	limb	NN
cord-006860-a3b8hyyr	5105	18	amputations	amputation	NNS
cord-006860-a3b8hyyr	5105	19	and	and	CC
cord-006860-a3b8hyyr	5105	20	deaths	death	NNS
cord-006860-a3b8hyyr	5105	21	.	.	.
cord-006860-a3b8hyyr	5106	1	Results	result	NNS
cord-006860-a3b8hyyr	5106	2	were	be	VBD
cord-006860-a3b8hyyr	5106	3	compared	compare	VBN
cord-006860-a3b8hyyr	5106	4	with	with	IN
cord-006860-a3b8hyyr	5106	5	a	a	DT
cord-006860-a3b8hyyr	5106	6	historical	historical	JJ
cord-006860-a3b8hyyr	5106	7	control	control	NN
cord-006860-a3b8hyyr	5106	8	of	of	IN
cord-006860-a3b8hyyr	5106	9	120	120	CD
cord-006860-a3b8hyyr	5106	10	IX	IX	NNP
cord-006860-a3b8hyyr	5106	11	-	-	HYPH
cord-006860-a3b8hyyr	5106	12	AT	AT	NNP
cord-006860-a3b8hyyr	5106	13	patients	patient	NNS
cord-006860-a3b8hyyr	5106	14	,	,	,
cord-006860-a3b8hyyr	5106	15	all	all	DT
cord-006860-a3b8hyyr	5106	16	confirmed	confirm	VBN
cord-006860-a3b8hyyr	5106	17	by	by	IN
cord-006860-a3b8hyyr	5106	18	the	the	DT
cord-006860-a3b8hyyr	5106	19	HIPA	HIPA	NNP
cord-006860-a3b8hyyr	5106	20	test	test	NN
cord-006860-a3b8hyyr	5106	21	,	,	,
cord-006860-a3b8hyyr	5106	22	but	but	CC
cord-006860-a3b8hyyr	5106	23	treated	treat	VBN
cord-006860-a3b8hyyr	5106	24	before	before	IN
cord-006860-a3b8hyyr	5106	25	rhirudin	rhirudin	NNS
cord-006860-a3b8hyyr	5106	26	was	be	VBD
cord-006860-a3b8hyyr	5106	27	available	available	JJ
cord-006860-a3b8hyyr	5107	1	(	(	-LRB-
cord-006860-a3b8hyyr	5107	2	Danaparoid	Danaparoid	NNP
cord-006860-a3b8hyyr	5107	3	,	,	,
cord-006860-a3b8hyyr	5107	4	Marcumar	Marcumar	NNP
cord-006860-a3b8hyyr	5107	5	,	,	,
cord-006860-a3b8hyyr	5107	6	no	no	DT
cord-006860-a3b8hyyr	5107	7	anticoagulation	anticoagulation	NN
cord-006860-a3b8hyyr	5107	8	)	)	-RRB-
cord-006860-a3b8hyyr	5107	9	.	.	.
cord-006860-a3b8hyyr	5108	1	Primary	primary	JJ
cord-006860-a3b8hyyr	5108	2	efficacy	efficacy	NN
cord-006860-a3b8hyyr	5108	3	analysis	analysis	NN
cord-006860-a3b8hyyr	5108	4	:	:	:
cord-006860-a3b8hyyr	5109	1	respunders	respunders	NNP
cord-006860-a3b8hyyr	5109	2	AI	AI	NNP
cord-006860-a3b8hyyr	5109	3	:	:	:
cord-006860-a3b8hyyr	5109	4	74%o	74%o	CD
cord-006860-a3b8hyyr	5109	5	,	,	,
cord-006860-a3b8hyyr	5109	6	A2	a2	NN
cord-006860-a3b8hyyr	5109	7	:	:	:
cord-006860-a3b8hyyr	5109	8	60	60	CD
cord-006860-a3b8hyyr	5109	9	%	%	NN
cord-006860-a3b8hyyr	5109	10	,	,	,
cord-006860-a3b8hyyr	5109	11	B	b	NN
cord-006860-a3b8hyyr	5109	12	:	:	:
cord-006860-a3b8hyyr	5109	13	44	44	CD
cord-006860-a3b8hyyr	5109	14	%	%	NN
cord-006860-a3b8hyyr	5109	15	,	,	,
cord-006860-a3b8hyyr	5109	16	C	c	NN
cord-006860-a3b8hyyr	5109	17	:	:	:
cord-006860-a3b8hyyr	5109	18	50	50	CD
cord-006860-a3b8hyyr	5109	19	%	%	NN
cord-006860-a3b8hyyr	5109	20	,	,	,
cord-006860-a3b8hyyr	5109	21	total	total	JJ
cord-006860-a3b8hyyr	5109	22	:	:	:
cord-006860-a3b8hyyr	5109	23	65	65	CD
cord-006860-a3b8hyyr	5109	24	%	%	NN
cord-006860-a3b8hyyr	5109	25	.	.	.
cord-006860-a3b8hyyr	5110	1	All	all	DT
cord-006860-a3b8hyyr	5110	2	adverse	adverse	JJ
cord-006860-a3b8hyyr	5110	3	events	event	NNS
cord-006860-a3b8hyyr	5110	4	beside	beside	IN
cord-006860-a3b8hyyr	5110	5	bleeding	bleed	VBG
cord-006860-a3b8hyyr	5110	6	complications	complication	NNS
cord-006860-a3b8hyyr	5110	7	had	have	VBD
cord-006860-a3b8hyyr	5110	8	been	be	VBN
cord-006860-a3b8hyyr	5110	9	judged	judge	VBN
cord-006860-a3b8hyyr	5110	10	to	to	TO
cord-006860-a3b8hyyr	5110	11	be	be	VB
cord-006860-a3b8hyyr	5110	12	caused	cause	VBN
cord-006860-a3b8hyyr	5110	13	by	by	IN
cord-006860-a3b8hyyr	5110	14	the	the	DT
cord-006860-a3b8hyyr	5110	15	underlying	underlie	VBG
cord-006860-a3b8hyyr	5110	16	disease	disease	NN
cord-006860-a3b8hyyr	5110	17	and	and	CC
cord-006860-a3b8hyyr	5110	18	not	not	RB
cord-006860-a3b8hyyr	5110	19	directly	directly	RB
cord-006860-a3b8hyyr	5110	20	related	relate	VBN
cord-006860-a3b8hyyr	5110	21	to	to	IN
cord-006860-a3b8hyyr	5110	22	r	r	NN
cord-006860-a3b8hyyr	5110	23	-	-	HYPH
cord-006860-a3b8hyyr	5110	24	hirndin	hirndin	NNP
cord-006860-a3b8hyyr	5110	25	.	.	.
cord-006860-a3b8hyyr	5111	1	Proportion	proportion	NN
cord-006860-a3b8hyyr	5111	2	of	of	IN
cord-006860-a3b8hyyr	5111	3	patients	patient	NNS
cord-006860-a3b8hyyr	5111	4	with	with	IN
cord-006860-a3b8hyyr	5111	5	event	event	NN
cord-006860-a3b8hyyr	5111	6	in	in	IN
cord-006860-a3b8hyyr	5111	7	the	the	DT
cord-006860-a3b8hyyr	5111	8	obse	obse	JJ
cord-006860-a3b8hyyr	5111	9	~	~	NFP
cord-006860-a3b8hyyr	5111	10	wation	wation	NN
cord-006860-a3b8hyyr	5111	11	period	period	NN
cord-006860-a3b8hyyr	5111	12	;	;	:
cord-006860-a3b8hyyr	5111	13	death	death	NN
cord-006860-a3b8hyyr	5111	14	:	:	:
cord-006860-a3b8hyyr	5111	15	A1	A1	NNP
cord-006860-a3b8hyyr	5111	16	5.9	5.9	CD
cord-006860-a3b8hyyr	5111	17	%	%	NN
cord-006860-a3b8hyyr	5111	18	,	,	,
cord-006860-a3b8hyyr	5111	19	A2	A2	NNP
cord-006860-a3b8hyyr	5111	20	0	0	CD
cord-006860-a3b8hyyr	5111	21	%	%	NN
cord-006860-a3b8hyyr	5111	22	,	,	,
cord-006860-a3b8hyyr	5111	23	B	b	NN
cord-006860-a3b8hyyr	5111	24	16.774	16.774	CD
cord-006860-a3b8hyyr	5111	25	,	,	,
cord-006860-a3b8hyyr	5111	26	C	c	NN
cord-006860-a3b8hyyr	5111	27	0	0	CD
cord-006860-a3b8hyyr	5111	28	%	%	NN
cord-006860-a3b8hyyr	5111	29	,	,	,
cord-006860-a3b8hyyr	5111	30	total	total	JJ
cord-006860-a3b8hyyr	5111	31	:	:	:
cord-006860-a3b8hyyr	5111	32	7.3	7.3	CD
cord-006860-a3b8hyyr	5111	33	%	%	NN
cord-006860-a3b8hyyr	5111	34	,	,	,
cord-006860-a3b8hyyr	5111	35	during	during	IN
cord-006860-a3b8hyyr	5111	36	rhirudin	rhirudin	NNP
cord-006860-a3b8hyyr	5111	37	treatment	treatment	NN
cord-006860-a3b8hyyr	5111	38	:	:	:
cord-006860-a3b8hyyr	5111	39	1.2	1.2	CD
cord-006860-a3b8hyyr	5111	40	%	%	NN
cord-006860-a3b8hyyr	5111	41	;	;	,
cord-006860-a3b8hyyr	5111	42	new	new	JJ
cord-006860-a3b8hyyr	5111	43	TEC	tec	NN
cord-006860-a3b8hyyr	5111	44	:	:	:
cord-006860-a3b8hyyr	5111	45	AI	AI	NNP
cord-006860-a3b8hyyr	5111	46	5.9	5.9	CD
cord-006860-a3b8hyyr	5111	47	%	%	NN
cord-006860-a3b8hyyr	5111	48	,	,	,
cord-006860-a3b8hyyr	5111	49	A2	a2	NN
cord-006860-a3b8hyyr	5111	50	0	0	CD
cord-006860-a3b8hyyr	5111	51	%	%	NN
cord-006860-a3b8hyyr	5111	52	,	,	,
cord-006860-a3b8hyyr	5111	53	B	B	NNP
cord-006860-a3b8hyyr	5111	54	27.8	27.8	CD
cord-006860-a3b8hyyr	5111	55	%	%	NN
cord-006860-a3b8hyyr	5111	56	,	,	,
cord-006860-a3b8hyyr	5111	57	C	c	NN
cord-006860-a3b8hyyr	5111	58	0	0	CD
cord-006860-a3b8hyyr	5111	59	%	%	NN
cord-006860-a3b8hyyr	5111	60	,	,	,
cord-006860-a3b8hyyr	5111	61	total	total	JJ
cord-006860-a3b8hyyr	5111	62	9.8	9.8	CD
cord-006860-a3b8hyyr	5111	63	%	%	NN
cord-006860-a3b8hyyr	5111	64	,	,	,
cord-006860-a3b8hyyr	5111	65	during	during	IN
cord-006860-a3b8hyyr	5111	66	rhirudin	rhirudin	NNS
cord-006860-a3b8hyyr	5111	67	:	:	:
cord-006860-a3b8hyyr	5111	68	2.4	2.4	CD
cord-006860-a3b8hyyr	5111	69	%	%	NN
cord-006860-a3b8hyyr	5111	70	;	;	,
cord-006860-a3b8hyyr	5111	71	limb	limb	NN
cord-006860-a3b8hyyr	5111	72	amputation	amputation	NN
cord-006860-a3b8hyyr	5111	73	:	:	:
cord-006860-a3b8hyyr	5111	74	AI	AI	NNP
cord-006860-a3b8hyyr	5111	75	3.9	3.9	CD
cord-006860-a3b8hyyr	5111	76	%	%	NN
cord-006860-a3b8hyyr	5111	77	,	,	,
cord-006860-a3b8hyyr	5111	78	A2	a2	NN
cord-006860-a3b8hyyr	5111	79	0	0	CD
cord-006860-a3b8hyyr	5111	80	%	%	NN
cord-006860-a3b8hyyr	5111	81	,	,	,
cord-006860-a3b8hyyr	5111	82	B	b	NN
cord-006860-a3b8hyyr	5111	83	5.6	5.6	CD
cord-006860-a3b8hyyr	5111	84	°	°	NNS
cord-006860-a3b8hyyr	5112	1	/0	/0	.
cord-006860-a3b8hyyr	5112	2	,	,	,
cord-006860-a3b8hyyr	5112	3	C	c	NN
cord-006860-a3b8hyyr	5112	4	0	0	CD
cord-006860-a3b8hyyr	5112	5	%	%	NN
cord-006860-a3b8hyyr	5112	6	,	,	,
cord-006860-a3b8hyyr	5112	7	total	total	JJ
cord-006860-a3b8hyyr	5112	8	:	:	:
cord-006860-a3b8hyyr	5112	9	3.7	3.7	CD
cord-006860-a3b8hyyr	5112	10	%	%	NN
cord-006860-a3b8hyyr	5112	11	,	,	,
cord-006860-a3b8hyyr	5112	12	during	during	IN
cord-006860-a3b8hyyr	5112	13	rbirudin	rbirudin	NNP
cord-006860-a3b8hyyr	5112	14	:	:	:
cord-006860-a3b8hyyr	5112	15	3.7	3.7	CD
cord-006860-a3b8hyyr	5112	16	%	%	NN
cord-006860-a3b8hyyr	5113	1	Eaapoiat	Eaapoiat	NNP
cord-006860-a3b8hyyr	5113	2	We	-PRON-	PRP
cord-006860-a3b8hyyr	5113	3	conclude	conclude	VBP
cord-006860-a3b8hyyr	5113	4	,	,	,
cord-006860-a3b8hyyr	5113	5	that	that	IN
cord-006860-a3b8hyyr	5113	6	r	r	NN
cord-006860-a3b8hyyr	5113	7	-	-	HYPH
cord-006860-a3b8hyyr	5113	8	hirndin	hirndin	NNP
cord-006860-a3b8hyyr	5113	9	is	be	VBZ
cord-006860-a3b8hyyr	5113	10	an	an	DT
cord-006860-a3b8hyyr	5113	11	effective	effective	JJ
cord-006860-a3b8hyyr	5113	12	anticoagulant	anticoagulant	NN
cord-006860-a3b8hyyr	5113	13	in	in	IN
cord-006860-a3b8hyyr	5113	14	HAT	hat	NN
cord-006860-a3b8hyyr	5113	15	typa	typa	NN
cord-006860-a3b8hyyr	5113	16	II	II	NNP
cord-006860-a3b8hyyr	5113	17	patients	patient	NNS
cord-006860-a3b8hyyr	5113	18	allowing	allow	VBG
cord-006860-a3b8hyyr	5113	19	rapid	rapid	JJ
cord-006860-a3b8hyyr	5113	20	re	re	NN
cord-006860-a3b8hyyr	5113	21	,	,	,
cord-006860-a3b8hyyr	5113	22	coveD	coveD	NNP
cord-006860-a3b8hyyr	5113	23	"	"	''
cord-006860-a3b8hyyr	5113	24	of	of	IN
cord-006860-a3b8hyyr	5113	25	platelet	platelet	NN
cord-006860-a3b8hyyr	5113	26	counts	count	NNS
cord-006860-a3b8hyyr	5113	27	.	.	.
cord-006860-a3b8hyyr	5114	1	Compared	compare	VBN
cord-006860-a3b8hyyr	5114	2	to	to	IN
cord-006860-a3b8hyyr	5114	3	a	a	DT
cord-006860-a3b8hyyr	5114	4	historical	historical	JJ
cord-006860-a3b8hyyr	5114	5	control	control	NN
cord-006860-a3b8hyyr	5114	6	the	the	DT
cord-006860-a3b8hyyr	5114	7	r	r	NN
cord-006860-a3b8hyyr	5114	8	-	-	HYPH
cord-006860-a3b8hyyr	5114	9	hirudin	hirudin	NN
cord-006860-a3b8hyyr	5114	10	group	group	NN
cord-006860-a3b8hyyr	5114	11	had	have	VBD
cord-006860-a3b8hyyr	5114	12	a	a	DT
cord-006860-a3b8hyyr	5114	13	strongly	strongly	RB
cord-006860-a3b8hyyr	5114	14	reduced	reduce	VBN
cord-006860-a3b8hyyr	5114	15	incidence	incidence	NN
cord-006860-a3b8hyyr	5114	16	of	of	IN
cord-006860-a3b8hyyr	5114	17	Combined	combined	JJ
cord-006860-a3b8hyyr	5114	18	endpuint	endpuint	NNS
cord-006860-a3b8hyyr	5114	19	of	of	IN
cord-006860-a3b8hyyr	5114	20	mortality	mortality	NN
cord-006860-a3b8hyyr	5114	21	,	,	,
cord-006860-a3b8hyyr	5114	22	limb	limb	NN
cord-006860-a3b8hyyr	5114	23	amputation	amputation	NN
cord-006860-a3b8hyyr	5114	24	and	and	CC
cord-006860-a3b8hyyr	5114	25	new	new	JJ
cord-006860-a3b8hyyr	5114	26	TECs	tec	NNS
cord-006860-a3b8hyyr	5114	27	.	.	.
cord-006860-a3b8hyyr	5115	1	Major	major	JJ
cord-006860-a3b8hyyr	5115	2	bleedings	bleeding	NNS
cord-006860-a3b8hyyr	5115	3	occurred	occur	VBD
cord-006860-a3b8hyyr	5115	4	slightly	slightly	RB
cord-006860-a3b8hyyr	5115	5	more	more	RBR
cord-006860-a3b8hyyr	5115	6	frequent	frequent	JJ
cord-006860-a3b8hyyr	5115	7	than	than	IN
cord-006860-a3b8hyyr	5115	8	in	in	IN
cord-006860-a3b8hyyr	5115	9	the	the	DT
cord-006860-a3b8hyyr	5115	10	historical	historical	JJ
cord-006860-a3b8hyyr	5115	11	control	control	NN
cord-006860-a3b8hyyr	5115	12	.	.	.
cord-006860-a3b8hyyr	5116	1	However	however	RB
cord-006860-a3b8hyyr	5116	2	,	,	,
cord-006860-a3b8hyyr	5116	3	the	the	DT
cord-006860-a3b8hyyr	5116	4	dosage	dosage	NN
cord-006860-a3b8hyyr	5116	5	used	use	VBN
cord-006860-a3b8hyyr	5116	6	in	in	IN
cord-006860-a3b8hyyr	5116	7	regimen	regimen	NN
cord-006860-a3b8hyyr	5116	8	B	B	NNP
cord-006860-a3b8hyyr	5116	9	might	may	MD
cord-006860-a3b8hyyr	5116	10	have	have	VB
cord-006860-a3b8hyyr	5116	11	been	be	VBN
cord-006860-a3b8hyyr	5116	12	too	too	RB
cord-006860-a3b8hyyr	5116	13	low	low	JJ
cord-006860-a3b8hyyr	5116	14	,	,	,
cord-006860-a3b8hyyr	5116	15	as	as	IN
cord-006860-a3b8hyyr	5116	16	flds	flds	NNP
cord-006860-a3b8hyyr	5116	17	group	group	NN
cord-006860-a3b8hyyr	5116	18	revealed	reveal	VBD
cord-006860-a3b8hyyr	5116	19	an	an	DT
cord-006860-a3b8hyyr	5116	20	effective	effective	JJ
cord-006860-a3b8hyyr	5116	21	anticoagulatiun	anticoagulatiun	NN
cord-006860-a3b8hyyr	5116	22	and	and	CC
cord-006860-a3b8hyyr	5116	23	increase	increase	VB
cord-006860-a3b8hyyr	5116	24	in	in	IN
cord-006860-a3b8hyyr	5116	25	platelet	platelet	NN
cord-006860-a3b8hyyr	5116	26	counts	count	NNS
cord-006860-a3b8hyyr	5116	27	in	in	IN
cord-006860-a3b8hyyr	5116	28	only	only	RB
cord-006860-a3b8hyyr	5116	29	43	43	CD
cord-006860-a3b8hyyr	5116	30	%	%	NN
cord-006860-a3b8hyyr	5116	31	and	and	CC
cord-006860-a3b8hyyr	5116	32	concomitantly	concomitantly	RB
cord-006860-a3b8hyyr	5116	33	had	have	VBD
cord-006860-a3b8hyyr	5116	34	the	the	DT
cord-006860-a3b8hyyr	5116	35	higl)est	higl)	JJS
cord-006860-a3b8hyyr	5116	36	incidence	incidence	NN
cord-006860-a3b8hyyr	5116	37	of	of	IN
cord-006860-a3b8hyyr	5116	38	new	new	JJ
cord-006860-a3b8hyyr	5116	39	TECs	tec	NNS
cord-006860-a3b8hyyr	5116	40	.	.	.